Miracle-dz/UniFAR-FTUs huggingface dataset:
A clinical comparative evaluation of periodontally accelerated osteogenic orthodontics with piezo and surgical bur: An interdisciplinary approach

Context: The orthodontic treatment in adult for the treatment of malocclusion is becoming more common. However, the disadvantages of conventional orthodontics are the time consumed for the treatment (18–24 months), root resorption, and formation of fenestrations and dehiscence. Periodontally accelerated osteogenic orthodontics (PAOO) is a surgical technique resulting in increased alveolar bone width, shorter treatment time, increase posttreatment stability, and decrease amount of apical root resorption. Aim: The aim of the study is to compare the treatment time, root resorption, bone density, and presence/absence of fenestrations and dehiscence after PAOO with surgical bur and PAOO with piezocision. Materials and Methods: Forty participants with bimaxillary protrusion undergoing orthodontic treatment were randomly selected and divided into two groups. Group I: 20 participants selected for PAOO with surgical bur and Group II: 20 participants selected for PAOO with piezocision. Patients were recalled at baseline 3, 6, 9, and 12 months and evaluated for treatment time and bone density, root resorption, and detection of fenestration and dehiscence using cone-beam computerized tomography (CBCT). Results: Participants in Group I had less treatment time compared to Group II. Rate of retraction was 7.07 mm/20.81 weeks and 5.99 mm/28.48 weeks in Group I and Group II, respectively. CBCT showed a statistically significant increase in bone density in both groups, 12 months after the surgery. Root resorption was negligible in Group I (0.34 mm) and in Group II (0.51 mm). CBCT revealed increase in thickness of alveolar bone and coverage of fenestrations and dehiscence. Conclusion: PAOO provides an efficient and stable orthodontic tooth movement.
Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation.

Purpose To determine whether human induced pluripotent stem (iPS) cell-derived retinal pigment epithelial (RPE) cells (iPS-RPE) can express complement factors. Methods To confirm expression of complement factors in human iPS-RPE cells, we performed flow cytometry, immunohistochemistry, ELISA, and quantitative RT-PCR for the following: C3, C5, CFB (Factor B), C5b-9 (membrane attack complex [MAC]), CFH (Factor H), CFI (Factor I), CD46, CD55, CD59, clusterin, and vitronectin. We also prepared iPS-RPE cells in the presence of recombinant IFN-γ, recombinant TNF-α, lipopolysaccharide, supernatants of naïve T cells, and T helper 1 (Th1) cells. For the transplantation, after preparation of iPS-RPE cells from cynomolgus monkeys, the iPS-RPE cells (allografts) were transplanted into the subretinal space in monkeys. After surgery, monkeys were euthanized for IHC evaluation of the retinal section and determination of complement factors (C3, C5, CFB, MAC, and C1q), cytokines, and immunoglobulin G (IgG). Results Human iPS-RPE cells expressed complement activators and inhibitors. iPS-RPE cells highly expressed complement factors during inflammatory conditions, especially IFN-γ exposure including Th1 cell supernatants. In immune attack eyes after allogeneic iPS-RPE cell transplantation, complement activators such as C3, CFB, C5, and MAC were detected around the host RPE layer, grafted RPE cells, inflammatory retinal lesions, and transplanted subretinal space. In addition, we observed a large number of C1q and IgG double positive and IFN-γ positive inflammatory cells in the retinal sections. Conclusions iPS-derived RPE cells greatly expressed complement factors. Thus, RPE cells might be activated and produce complement factors after exposure to infiltrating inflammatory cells in the eye.
Adult Attachment Security and Different Types of Relational Violence Victimization Among College-Age Couples.

This study aims to understand the associations between adult attachment security and different types of intimate partner violence victimization including that of emotional abuse, physical violence, and sexual coercion among heterosexual couples. Participants included 87 couples with the mean age 22.3 years. An actor-partner interdependence model was fit to the data. Findings indicated that adult attachment security accounted for 15% of the variance in the emotional abuse victimization of females, 9% of the variance in the sexual coercion victimization of females, and 7% of the variance in minor physical victimization of males. This may significantly impact risk factor assessment, and contribute to improved therapeutic intervention and increased understanding of the development and progression of relationship violence.
Developing a meta-inventory of human values

Human values are increasingly being used as a concept in a wide range of fields including psychology, sociology, anthropology, science and technology studies, and information science. However, the use of this concept varies widely in these different fields, and several different instruments have been developed separately to measure values. This paper reviews research to date on values in all of these fields to develop a definition of values, and then reviews 12 value inventories to create a meta-inventory.
Comparative morbidities and the share of emergencies in hospital admissions in deprived areas: a method and evidence from English administrative data

Objective Various studies find that the share of emergencies in hospital admissions is higher in deprived areas, but both the explanation and policy implications are unclear. We estimate the extent to which this finding is due to a different disease mix in deprived areas, rather than other explanations such as patient behaviour and general practitioner effectiveness. Design Secondary analysis using English Hospital Episode Statistics data, with disease for elective and emergency admissions in 2008/2009 coded at 186 blocks or 1230 categories and aggregated to lower layer super output area of residence. It is then linked to an appropriate measure of deprivation. Outcome measures The difference in the share of emergencies in hospital admissions between communities in the highest and lowest deciles of deprivation; and the percentage of this difference that is explained if areas in the least deprived decile have the same disease mix as those in the most deprived decile. Results Using the finest disease classification scheme (1230 categories), 71% of the higher share of admissions that were emergencies in decile 1 areas relative to decile 10, is explained by the “adverse” case mix (CM) in deprived areas. The remainder reflects the higher relative use of emergency care in deprived areas for the same conditions. Higher incidence of respiratory and circulatory diseases in deprived areas explains about 30% of the CM contribution. Diseases of the digestive system and abdomen have a high relative use of emergency care in deprived areas. Conclusions The higher use of emergency care in deprived areas is primarily a symptom of the higher prevalence of diseases which have high national rates of emergency to elective care—especially respiratory diseases—rather than an indication of less effective primary care. Nevertheless, there is a higher share of emergency care in admissions in deprived areas for several diseases, most notably of the digestive system.
Electrodermal Activity based Classification of Induced Stress in a Controlled Setting

It has become common for people to experience stress, mainly because of its eclectic nature – physical, psychological, emotional, social, etc. Unmonitored stress may prove harmful to one’s health resulting in even chronic diseases. Since stress is very subjective, stress management is not straightforward. Many attempts have been made to detect and quantify stress. However, an accurate assessment can be made from physiological measurements only. In this study, we have demonstrated how electrodermal activity (EDA), which represents the sympathetic response to stress, could be used for accurate classification of stress by developing a machine learning based classification model. 30 participants were subjected to Trier Social Stress Test (TSST), and EDA and accelerometer data were recorded using a wrist-worn device. Datasets containing stress and non-stress periods were segmented and manually tagged for model training, based on recorded stress protocol timeline. A kNN-classifier model was trained on datasets from 15 participants and tested on datasets from the remaining 15 participants, and the results were verified with salivary cortisol levels recorded before and after TSST. The proposed kNN classifier has sensitivity and specificity of 94% and 93% respectively. Motion corruptions due to hand movements were detected using the accelerometer data and were classified as ‘motion affected’. The classifier was able to classify – the baseline regions of all participants as non-stress, 93% of the TSST regions as stress and 63% of the post-stress regions as non-stress.
Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women

Most studies reporting on the association of circulating testosterone levels with type 2 diabetes in men are of cross-sectional design. Reports on the relevance of altered testosterone levels in women are scarce. Here, we evaluate the role of low serum testosterone levels for incident diabetes in men and women in a population setting of 7706 subjects (3896 females). During a mean follow up time of 13.8 years, 7.8% developed type 2 diabetes. Significant correlations of testosterone with high density lipoprotein (HDL)-cholesterol (R = 0.21, p < 0.001), body-mass-index (R = −0.23, p < 0.001), and waist-to-hip-ratio (R = −0.21, p < 0.001) were found in men. No correlation was found with age in men; in women, the correlation was negligible (R = 0.04, p = 0.012). In men, low testosterone levels predicted high risk of type 2 diabetes, while in women this relationship was opposite. Men with low testosterone levels showed increased risk of future diabetes (hazard ratio (HR) 2.66, 95% confidence interval (CI) 1.91–3.72, p < 0.001 in basic model; HR 1.56 95%, CI 1.10–2.21, p = 0.003). In women, low testosterone levels indicated lower risk with (HR 0.53, 95% CI 0.37–0.77, p = 0.003), while the association lost significance in the fully adjusted model (HR 0.72, 95% CI 0.49–1.05, p = 0.09). Low levels of testosterone predicted future diabetes in men. A borderline opposite association was found in women.
Modelling of Solution Processed Indium Arsenide Nanowire Microwave Switches

This paper presents the modelling of a coplanar-waveguide bottom-gated FET switch using indium-arsenide nanowires. The nanowires have been included on the switch using dielectrophoresis, which is a solution processable technique. This is a necessary first step towards developing a fully printable switch on a flexible substrate, for low cost microwave devices, built using additive manufacturing methods. The measured S-parameters show the switching capabilities of the device with an insertion loss of 9 dB, when the switch is open (gate voltage $\geq \mathbf{60}\ \mathbf{V}$). The development of a distributed circuit model that matches the measured data is described, alongside the calculated network parameters used to represent the coplanar-waveguide and the nanowires. The model fits the measured results within 8%, making it suitable for inclusion in a CAD based circuit simulator.
Using Heterogeneous Social Media as Auxiliary Information to Improve Hotel Recommendation Performance

Research conducted on social media is currently increasing. Information obtained by users of social media has resulted in the development of many recommendation systems that analyze user preferences in an attempt to locate the most suitable products for recommendation to users. A great number of people have used social media platforms, such as Twitter, to develop a hotel recommendation system. Here, we propose a Twitter-based recommendation system via the aid of heterogeneous social media. First, a model is designed to predict user preferences by improving matrix factorization based on user preferences and users’ personal data, where basic information about hotels collected from Yelp is used as auxiliary information. On the other hand, an analytical user posting behavior algorithm is created for establishing users’ posting behavior vectors based on earlier posts in Twitter and Yelp. This results of the experiments show that the proposed method can improve accuracy by 30% in terms of RECALL compared with the Twitter-based recommendation system without the use of heterogeneous social media. Furthermore, it can improve the accuracy of the mean reciprocal rank by 80% and can increase precision by as much as 100%.
Small Nucleolar RNA Host Gene 18 Acts as a Tumor Suppressor and a Diagnostic Indicator in Hepatocellular Carcinoma

Background: Noncoding RNAs are crucial regulators acting as either tumor suppressor genes or oncogenes in human cancer progression. The aberrant expression of noncoding RNAs has been confirmed in different kinds of cancers. Hepatocellular carcinoma is one of the most common malignant tumors worldwide, characterized by insidious onset, great malignancy, and high rates of recurrence and metastasis. Due to lack of early predictive markers, numerous patients are diagnosed in the late stages. As therapeutic options for advanced patients are quite limited, great efforts have been made to screen patients at early stages. A previous study reported that small nucleolar RNA host gene 18 played crucial role in glioma. However, its functions and roles in hepatocellular carcinoma are unknown. Purpose: To explore its functional role and diagnostic value in hepatocellular carcinoma, we investigated its expression level. Methods: We performed real-time quantitative polymerase chain reaction in tumor tissues and adjacent noncancerous tissues derived from patients with hepatocellular carcinoma as well as in plasma, including samples from the healthy control, patients with hepatitis B, cirrhosis, and hepatocellular carcinoma. Results: Small nucleolar RNA host gene 18 was downregulated in liver tissues compared to paired adjacent noncancerous tissues (P < .0001). Meanwhile, plasma small nucleolar RNA host gene 18 showed a relatively high sensitivity and specificity (75.61% and 73.49%) for distinguishing patients with hepatocellular carcinoma whose α-fetoprotein levels were below 200 ng/mL from the healthy controls. Conclusion: Our study suggested that small nucleolar RNA host gene 18 might act as a tumor suppressor gene in hepatocellular carcinoma and potentially a diagnostic indicator to distinguish hepatocellular carcinoma from the healthy control and cirrhosis.
Image Compressed Sensing Recovery based on Multi-scale Group Sparse Representation

Compressed Sensing (CS) is intended to recover a high-dimensional but sparse vector by a small number of linear sampling. Seeking an appropriate domain is of great importance to achieve a high enough degree of sparsity. In this paper, we propose a new scheme for image Compressed Sensing using multiscale strategy and structural group sparse representation, which efficiently characterizes the sparsity and multi-scale self-similarity of natural images in an adaptive group domain. Then, the group sparsity constraint and multi-scale self-similarity are exploited simultaneously under a unified framework. A multi-scale image pyramid is generated to construct the group during reconstruction. Meanwhile, effective dictionaries for each group are trained from the recovery image itself by a group-adaptive dictionary learning algorithm. Experimental results demonstrate that the proposed algorithm increases image CS recovery quality significantly and outperforms the state-of-the-art methods.
Wideband 220 – 330 GHz Turnstile OMT Enabled by Silicon Micromachining

This paper is the first publication on the first turnstile-junction orthogonal mode transducer (OMT) above 110 GHz, which is enabled by silicon micromachining. In contrast to other OMT concepts, turnstile OMTs are wideband and allow for co-planar ports, but require accurate and complex fabrication and have therefore, to the best of our knowledge, not been implemented above 110 GHz in any technology. As shown in this paper, the fabrication and assembly accuracy of silicon micromachining enables the realization of such complex OMT designs at 220 – 330 GHz with excellent performance. The measured insertion loss is better than 0.7 dB for the whole waveguide band, with mean values of 0.34 dB and 0.48 dB for the vertical and horizontal polarizations, respectively. The measured return loss for both polarizations, even with an open-ended common port, is better than 14 dB for the whole waveguide band, and an average level of 18 dB. An estimation of the worst-case cross-polarization level, derived from measurements, results in at least 20 dB for the whole waveguide band, with an average of 25 dB for the upper half of the band.
FusionNet and AugmentedFlowNet: Selective Proxy Ground Truth for Training on Unlabeled Images

Recent work has shown that convolutional neural networks (CNNs) can be used to estimate optical flow with high quality and fast runtime. This makes them preferable for real-world applications. However, such networks require very large training datasets. Engineering the training data is difficult and/or laborious. This paper shows how to augment a network trained on an existing synthetic dataset with large amounts of additional unlabelled data. In particular, we introduce a selection mechanism to assemble from multiple estimates a joint optical flow field, which outperforms that of all input methods. The latter can be used as proxy-ground-truth to train a network on real-world data and to adapt it to specific domains of interest. Our experimental results show that the performance of networks improves considerably, both, in cross-domain and in domain-specific scenarios. As a consequence, we obtain state-of-the-art results on the KITTI benchmarks.
17β-estradiol modulates NGF and BDNF expression through ERβ mediated ERK signaling in cortical astrocytes

Abstract17β-estradiol is known to exert neurotrophic and neuroprotective effects through classical estrogen receptors [ERs], ERα and ERβ, on a variety of cell types either by genomic or non-genomic actions. The actions of estradiol on glial cells are important to maintain metabolic functions of the nervous system. Astrocytes are considered to be active participants in brain activity because of their ability to release growth factors, including neurotrophins. Present in vitro studies show that 17β-estradiol modulates NGF and BDNF expression in time-dependent manner and ERK acts as secondary messenger for estradiol’s action. 17β-estradiol is involved in survival of cortical astrocytes. In conclusion, this study indicates vital role of ERβ mediated ERK signalling for regulation of NGF and BDNF expression along with cell viability of cortical astrocytes which further confirms the role of ERs, particularly ERβ in glial cells’ functions and viability.
The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx

The retinal degeneration model rd10 contains a missense mutation of the catalytic PDE6 β subunit, which hydrolyzes cGMP in response to light. This model produces cell death more slowly than others caused by PDE6 loss of function, making it of particular interest for studying potential therapeutics. We used morphology, biochemistry, and single-cell physiology to examine the mechanism of rd10 degeneration. Our results show that the mutation produces no alteration of Pde6b RNA but does dramatically decrease maximal and basal PDE6 activity, apparently caused by a decrease in protein stability and transport. The enzymatic properties of the remaining mutant PDE6 appear to be nearly normal. We demonstrate that an increase in free cGMP, which would result from decreased PDE6 activity and serve to increase opening of the cGMP-gated channels and calcium influx, is an underlying cause of cell death: degeneration of rd10/Cngb1−/− double mutants is slower than the parent rd10 line. Paradoxically, degeneration in rd10/Cngb1−/− is also slower than in Cngb1−/−. This rescue is correlated with a lowering of cGMP content in Cngb1−/− retinas and suggests that it may be caused by mislocalization of active PDE6. Single-cell recordings from rd10 rods show that the rates of rise and decay of the response are significantly slower; simulations indicate that these changes are primarily the result of the decrease in PDE6 concentration and rod collecting area. Together, these results provide insights into the complex mechanisms that underlie rd10-mediated retinal degeneration and a cautionary note for analysis of therapeutic interventions.
Modular Wideband 1–15 GHz Transmitter Channelizer for High Data Rate Communication

This work presents a modular wideband transmitter channelizer for high data rate communication applications, manufactured in a 130 nm SiGe:C BiCMOS technology with fT / fmax= 300/500 GHz. Three independent I/Q baseband signals are upconverted to different intermediate frequencies and then bonded in current domain. A local oscillator leakage cancellation functionality is implemented on chip within the input stage to enhance the dynamic range. Single ended inputs were utilized in order to reduce the pin count, for a more practical realization and higher potential toward future system scaling. The transmitter channelizer achieves an output 3-dB bandwidth of 15 GHz. LO rejection of 74 dBc at the center frequency was measured after calibration. It dissipates 355 m Wand occupies 1.5 mm2. With these specifications the presented circuitry suits well as a practical solution for wideband channelization for high data rate transmission scenario's, such as THz and sub-THz communications applications, with a potential scaling-up to higher number of channels.
On Designing and Evaluating Phishing Webpage Detection Techniques for the Real World

While a plethora of apparently foolproof detection techniques have been developed to cope with phishing, it remains a continuing problem with an increasing number of attacks and victims. This is due to a gap between the reported experimental detection accuracy of solutions from the academic literature and their actual effectiveness in real-world scenarios. For instance, design choices made while only considering how to maximize the accuracy of phishing detection sometimes has the unintended effect of constraining deployability or limiting usability. We hope to raise awareness about practices causing this gap and present a set of guidelines for the de-sign and evaluation of phishing webpage detection techniques. These guidelines can improve the effectiveness of phishing detection techniques in real-world scenarios and foster technology transfer. They also facilitate unbiased comparison of evaluation results of different detection techniques.