Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioinformatics Analysis and Insights for the Role of COMMD7 in Hepatocellular Carcinoma

Background: The tumorigenesis and development of hepatocellular carcinoma (HCC) is a process involving multiple factors. The COMMDs family proteins were reported to play important roles in various disease and cancers including HCC. We previously found COMMD7 acted as a HCC-promotion factor; however, further understanding on COMMD7 was needed. We conducted these bioinformatics analysis for the purpose of comprehensive understanding of the functional role of COMMD7 in HCC.Methods: The bioinformatics analysis of COMMD7 were launched by online platforms including KEGG, GEPIA, cBioportal, Gene Ontology and The Kaplan-Meier plotter. Data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) were downloaded, and the data analysis and processing were conducted by RStudio (version 1.3.959) software.Results: The expression profile results of COMMD7 in TCGA and GTEx database suggested that COMMD7 expressed highly in liver tumor tissues and positively related with poorer prognosis (p<0.01); COMMD7 also contributed to the early development of HCC as its higher expression resulted in progression from stage I to stage III (p<0.01). Based on our previous studies, COMMD7 may target NF-κB signaling and CXCL10 to enhance the proliferation of hepatoma cells so that promoting the development of HCC. Conclusions：This study updates the current studies about the newly recognized roles of COMMD7 in the progression of HCC, summarizing the research progress and prospects of COMMD7 comprehensively, offering an outlook for the future investigation and targeted therapy of HCC.
Exposure to High or Low Glucose Levels Accelerates the Appearance of Markers of Endothelial Cell Senescence and Induces Dysregulation of Nitric Oxide Synthase

To test the hypothesis that aging impairs endothelial cell response to glucose stress, we utilized a human umbilical vein endothelial cell in vitro model in which clinically relevant concentrations of normal (5.5 mM), high (25 mM), and low (1.5 mM) glucose were tested. With advancing population doubling, exposure to normal glucose gradually decreased endothelial nitric oxide synthase expression and activity, resulting in slow, progressive development of markers of cell senescence (by population doubling level [PDL] 44). High or low glucose treatment accelerated the appearance of markers of senescence (by ~PDL 35) along with declines in endothelial nitric oxide synthase expression and activity. Human umbilical vein endothelial cells exposed to alternating low and high glucose gave even more rapid acceleration in the appearance of markers of senescence (by ~PDL 18) and reduction in endothelial nitric oxide synthase levels. Thus, exposure to low and high glucose induces earlier appearance of markers of endothelial cell senescence and dysregulation of the nitric oxide synthase gene and protein expression and function. These findings will help to elucidate endothelial dysfunction associated with glucose intolerance and improve future therapy for diabetic seniors.
Investigation of coseismic and postseismic processes using in situ measurements of seismic velocity variations in an underground mine

The in situ mechanical response of a rock mass to a sudden dynamic and static stress change is still poorly known. To tackle this question, we conducted an experiment in an underground mine to examine (1) the influence of dynamic and static stress perturbations on seismic velocities, (2) elastic static stress changes, and (3) induced earthquake activity associated with the blast and removal of a portion of hard rock. We accurately (0.01%) measured seismic velocity variations with ambient seismic noise correlations, located aftershock activity, and performed elastic static stress modeling. Overall, we observe that the blast induced a sudden decrease in seismic velocities over the entire studied area, which we interpreted as the damage due to the passing of strong seismic waves. This sudden process is followed by a slow relaxation lasting up to 5 days, while seismic activity returns to its background level after 2 days. In some locations, after the short‐term effects of the blast have subsided, the seismic velocities converge to new baseline levels and permanent changes in seismic velocity become visible. After comparing the spatial pattern of permanent seismic velocity changes with elastic static stress modeling, we infer that the permanent seismic velocity changes are due to the change in the static volumetric stress induced by the removal of a solid portion of rock by the blast. To our knowledge, this is the first observation of noise‐based permanent seismic velocity changes associated with static stress changes.
Pattern Recognition of Alzheimer ' s disease on PET images

Alzheimer's disease (AD) causes degenerative changes in the nervous tissue, which results in progressive loss of memory and cognitive functions. Alzheimer's disease is the most frequent type of dementia. The prevalence of Alzheimer's disease increases in the elderly patients, and given the fa ct that population is getting older it is expected that inc idence increases. Currently, there is no cure for Alzheime r's disease, but early diagnosis and treatment can slow its progression. The Positron Emission Tomography (PET) examination specifies the functional changes in the human brain and it is an useful tool in analyzing t he cerebral blood flow. The regional abnormalities for Alzheimer’s disease cause the reduction of blood fl w, mainly the temporal lobe, parietal lobe and hippocampus. However, the difficulty of the analysi s and interpretation of PET imaging in the diagnosis of Alzheimer's disease led to the use of methods of pa ttern recognition on PET imaging as a tool for automatic diagnosis of Alzheimer's disease. In this work, we used the -nearest neighbour and Boosting methods in discrimination between the AD and Normal classes, Mild Cognitive Impairment (MCI) and Normal, and finally between the AD and MCI classes, with the purpose of making them a useful a nd effective tool in the automatic diagnosis of Alzhei m r's disease. The implementation of the MCI class, rarel y studied, allows the early diagnosis of Alzheimer's disease through the binary distinction between the MCI and Normal classes. Both methods are afflicted by t he problem of "curse of dimensionality ". The Boosting algorithm Adaboost achieved better performance than -nearest neighbour method in all discrimination between classes. Thus, the Boosting method adapted better to the problem of "curse of dimensionality" and has serious potential to become a tool for automatic diagnosis of Alzheimer's disease .
Potential risks to human health of LEDs Final Opinion

2 ACKNOWLEDGMENTS . 3 1. SUMMARY . 7 2. MANDATE FROM THE EU COMMISSION SERVICES . 10 2.1 Background . 10 2.2 Terms of Reference (ToR) . 11 3. OPINION . 12 4. MINORITY OPINIONS . 16 5. DATA AND METHODOLOGY . 17 5.1 Data/Evidence. 17 5.2 Methodology . 18 6. ASSESSMENT . 20 6.1. Photometry and radiometry . 20 6.2 Physical characteristics of LEDs sources . 21 6.3 Point source vs diffuse source . 22 6.4. The interaction between light and matter . 23 6.5. Eye optics fundamentals . 23 6.5.1 Thermal and photochemical aspects . 24 6.5.2. The effects on the healthy eyes . 25 6.5.2.1. Computer Vision Syndrome . 25 6.5.2.2 Anterior Segment of the Eye . 26 6.5.2.3 Posterior Segment of the Eye . 26 6.5. 3 Potential effects on the non-healthy eyes . 28 6.5. 4. Vulnerable and susceptible populations . 28 6.5. 4.1. Children . 28 6.5. 4.2. Adolescent . 28 6.5. 4.3. Elderly population . 28 6.7 Optical radiation effects on skin . 32 6.7. 2 Effects of LED reported in the literature (photodermatoses) . 33 6.7. 2.2 Case reports . 34 6.7. 3 Conclusions. 34 6.8 Circadian rhythms . 34 6.8. 1 Synchronisation and regulation of the circadian rhythm by light . 34 6.8. 3 Influence by optical radiation including LEDs . 35 6.8. 3.1 Disturbance of the circadian rhythm by LEDs sources . 35 6.8. 4 Consequences of disturbance of the circadian rhythm by light . 37 6.8. 5 Vulnerable and susceptible populations . 37 6.8. 6 Conclusions. 38 6.9 Temporal Light Modulation (Flicker) and potential health effects . 38 Potential risks to human health of LEDs Final Opinion 6 6.9. 1 Conclusion . 40 6.10 Exposure and health risk scenarios . 40 6.11 Overall conclusion: . 41 7. RECOMMENDATIONS FOR FUTURE WORK . 42 8. CONSIDERATION OF THE RESPONSES RECEIVED DURING THE CONSULTATION PROCESS . 43 9. REFERENCES . 44 10. GLOSSARY OF TERMS . 55 11. LIST OF ABBREVIATIONS . 60 ANNEX I LED Technologies. 64 ANNEX II The interaction between light and matter . 69 ANNEX III Structure of the skin, Fitzpatrick skin type and optical radiation effects on skin . 72 ANNEX IV Photometry, Radiometry and Dosimetry . 87 ANNEX V Circadian rhythm . 89 ANNEX VI Hazardous waste due to the materials used for producing Light-Emitting Diodes (LEDs) . 92 ANNEX VII: Literature review . 93 Potential risks to human health of LEDs Final Opinion
Hät, här, höt and hör - An Articulatory and Acoustic Study of the Swedish Vowels /ɛ:/ and /ø:/

This thesis is concerned with the examination of the Swedish vowels /ɛ:/ and /o:/ for qualitative differences between their pre-r allophones and the allophones occurring in other contexts. For this purpose, electromagnetic articulography and speech recordings were carried out on Swedish speakers from the two dialectal areas Malmo and Stockholm. Articulatory and acoustic analyses of the collected data show that the pre- r allophone of /ɛ:/ has a significantly more open vowel quality compared to its pre-t allophone in the dialects spoken around Malmo and Stockholm. Tongue position data suggest the same for the pre-r allophone of /o:/, although this could not be supported by the results of the formant analysis. The data further suggest that there is a significantly larger difference in openness in the East Swedish dialects than in the Southern ones.
Upward Income Mobility and Legislator Support for Education Policies

This paper investigates how upward mobility affects legislator voting behavior towards education policies. We develop an electoral competition model where voters are altruistic parents and politicians are office seeking. In this setting the future economic status of the children is affected both by current public education spending and by the level of upward mobility. Using a newly compiled dataset of roll call voting on California education legislation matched with electoral district-level upward mobility we find that the likelihood of a legislator voting "no" on redistributive education bills decreases by 10 percentage points when upward mobility in his electoral district decreases by a standard deviation.
Efecto de las barreras de innovación en la capacidad de absorción de las empresas innovadoras

This paper studies the importance of the absorption capacity of innovative companies and the effect of innovation barriers on it. The management of absorption capacity investment as an innovation promoter is also reviewed and the implications are exposed to the level of performance of the companies in matters of processes and market position. The analysis is performed using simple and multiple linear regression models. Finally, the impact of innovation on companies was obtained through a Principal Component Analysis.
The HMG-CoA reductase inhibitor rosuvastatin promotes complement factor H expression in apolipoprotein E-knockout mice

The aim of this study was to investigate the relationship between plaque severity and the expression of complement factor H (CFH) in an apo E-knockout mouse model of atherosclerosis. An additional objective was to determine the effect of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) on this relationship. Eight-week-old apo E-knockout mice were divided randomly into 2 groups: group A (atherosclerotic model group, n=14), and group B (rosuvastatin-treated group, n=8). Ten ageand genetic background-matched healthy C57BL/6 mice were used as a control group. After 20 weeks of continuous intragastric rosuvastatin administration, aorta samples were taken for H&E and immunohistochemical staining. Quantitative real-time PCR was performed to determine the level of CFH transcription, and western blot analysis was performed to measure CFH protein expression. Immunohistochemical staining showed that CFH was expressed in group A, and this was accompanied by increased mRNA and protein levels and the severity of atherosclerosis. However, none of these changes were observed in the control group. Rosuvastatin upregulated CFH mRNA expression and increased CFH protein levels. The plasma level of cholesterol was higher in group A than that in the control group (P<0.05). Furthermore, serum high-sensitive C-reactive protein and C3a levels decreased significantly in group B compared with those in group A (P<0.05). This study verified expression of CFH in atherosclerotic plaques in apo E-knockout mice and shows that rosuvastatin attenuated lesions and stabilized aortic plaques, possibly by increasing the expression of CFH and suppressing inflammation.
LAND ALLOCATION AMONG THE MAIN CROPS IN ARGENTINA: ESTIMATION OF PRICE AND LAND ELASTICITIES

In the past twenty years, there have been significant changes in land allocation among the main crops in Argentina. The aim of this paper was to analyze how those changes responded to variations in their relative prices in the short-term and quantify their responses. Additionally, it focused on understanding how the hectares devoted to a particular crop responded to changes in the total planted area. For this purpose a system of land allocation equations was estimated for the period 1980-2014. The results showed that the area planted with corn, soybean, sunflower and wheat responded to their own prices, being inelastic in all cases. A statistically significant and negative cross-price elasticity was observed for sunflower and corn. The other cross-price elasticities showed substitution for land use but they were not statistically significant. The land elasticities revealed to be elastic for wheat and inelastic for corn, soybean and sunflowers, while not significant for sorghum
Psychodynamic approaches to violence

The assessment and management of violent behaviour in mentally disordered patients are no longer the sole domain of forensic psychiatrists, but are increasingly part of the day-to-day work of all psychiatrists and mental health professionals. Violence risk assessment has become a huge industry, and although the importance of dynamic, as well as actuarial, risk factors is now recognised, a more systematic approach exploring the psychodynamics in the aetiology, assessment and treatment of violent behaviour is often lacking. In this article I revisit some of the key psychodynamic principles and concepts relevant to an understanding of violence, summarising the historical contributions of key psychoanalytic writers on violence and aggression, and exploring the ideas of more contemporary writers working in the field of forensic psychotherapy. A psychodynamic framework for working with violent patients is introduced, focusing on the setting and containment, specific therapeutic interventions and monitoring counter- transference reactions.
Characterization of three cell lines established from medaka embryos

We established three cell lines from medaka embryos. In the present study, we investigated the optimal conditions for growth of these cells with regard to the basal culture medium and concentration of fetal bovine serum (FBS). The best cell growth for all three cell lines was achieved with a 1:1 mixture of L15 medium and 199 medium with a relatively high concentration (20%) of FBS. The growth curves for the cell lines revealed that their doubling times ranged from 48 to 93 h. We also analyzed the numbers of chromosomes in the cell lines and found that their numbers varied from near-diploid to hyper-tetraploid. The results of the present study should be helpful for research in fish cell culture.
Паттерн генетического разнообразия у локальных и коммерческих пород свиней на основе анализа микросателлитов

One of the main tasks of genetics and animal breeding is the assessment of genetic diversity and the study of genetic relationships between different breeds and populations using molecular genetic analysis methods. We analysed the polymorphism of microsatellites and the information on the state of genetic diversity and the population structure of local breeds in Russia: the Kemerovo, the Berkshire, the Liven, the Mangalitsa, and the Civilian; in the Republic of Belarus: the Large White and the Black-and-White; and in Ukraine: the White Steppe, as well as commercial breeds of imported origin of domestic reproduction: the Large White, the Landrace, and the Duroc. The materials used for this study were the tissue and DNA samples extracted from 1,194 pigs and DNA of the UNU “Genetic material bank of domestic and wild animal species and birds” of the L.K. Ernst Federal Research Center for Animal Husbandry. Polymorphisms of 10 microsatellites (S0155, S0355, S0386, SW24, SO005, SW72, SW951, S0101, SW240, and SW857) were determined according to the previously developed technique using DNA analyser ABI3130xl. To estimate the allele pool of each population, the average number of alleles (NA), the effective number of alleles (NE ) based on the locus, the rarified allelic richness (AR), the observed (HO ) and expected (HE ) heterozygosity, and the fixation index (FIS) were calculated. The degree of genetic differentiation of the breeds was assessed based on the pairwise values of FST and D. The analysis of the allelic and genetic diversity parameters of the local breeds showed that the maximum and minimum levels of polymorphism were observed in pigs of the Ukrainian White Steppe breed (NA = 6.500, NE = 3.709, and AR = 6.020) and in pigs of the Duroc breed (NA = 4.875, NE = 2.119, and AR = 3.821), respectively. The highest level of genetic diversity was found in the Large White breed of the Republic of Belarus (HO = 0.707 and NE = 0.702). The minimum level of genetic diversity was found in pigs of the imported breeds – the Landrace (HO = 0.459, HE = 0.400) and the Duroc (HO = 0.480, HE = 0.469) – indicating a high selection pressure in these breeds. Based on the results of phylogenetic analysis, the genetic origin of Large White pigs, the breeds, from which the Berkshire pigs originated, and the genetic detachment of the Landrace from the Mangalitsa breeds were revealed. The cluster analysis showed a genetic consolidation of the Black-and-White, the Berkshire, and the Mangalitsa pigs. Additionally, the imported breeds with clustering depending on the origin were characterised by a genetic structure different from that of the other breeds. The information obtained from these studies can serve as a guide for the management and breeding strategies of the pig breeds studied, to allow their better use and conservation.
Characterization of (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-Trien-1-Ol with Antioxidant and Antimicrobial Potentials from Euclea Crispa (Thunb.) Leaves

(2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol or farnesol is a natural isoprenoid possessing a range of beneficial biological activities as anti-candidiasis, anti-tumor and anti-hyperglycaemia. The present study, for the first time, isolated and identified farnesol from Euclea crispa leaves’ extract, subsequently, validated its antioxidant and antimicrobial potentials. The isolated compound was confirmed by spectroscopic techniques including ultraviolet-visible (UV/Vis), fourier-transform infrared (FTIR), and 1H and 13C magnetic resonance (NMR) spectroscopies. By in vitro investigations, farnesol exhibited a considerable antioxidant activity with IC50 values of 113.79, 109.59, and 116.65 µg/mL for 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl, and nitric oxide radical scavenging assays, respectively. Additionally, farnesol performed a potent reducing power capacity which was in line with ascorbic acid, an outstanding antioxidant. By the disc-diffusion assay, farnesol exposed the superior antimicrobial activity against various disease-causing microorganisms. Significantly, at the concentration of 50 µg/mL, the compound effectively inhibited the growth of Escherichia coli and Aspergillus niger with inhibition zones of 12 and 11 mm, respectively. Findings from this research suggest that E. crispa leaf is a potential source of farnesol, a powerful antioxidant and antimicrobial agent.
Cornea Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC 4 A 11 Mutation

Citation: Alka K, Casey JR. Ophthalmic nonsteroidal anti-inflammatory drugs as a therapy for corneal dystrophies caused by SLC4A11 mutation. Invest Ophthalmol Vis Sci. 2018;59:4258–4267. https://doi.org/ 10.1167/iovs.18-24301 PURPOSE. SLC4A11 is a plasma membrane protein of corneal endothelial cells. Some mutations of the SLC4A11 gene result in SLC4A11 protein misfolding and failure to mature to the plasma membrane. This gives rise to some cases of Fuchs’ endothelial corneal dystrophy (FECD) and congenital hereditary endothelial dystrophy (CHED). We screened ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) for their ability to correct SLC4A11 folding defects.
PRESERVING VECTOR QUANTIZATION BASED SPEAKER RECOGNITION SYSTEM

In the recent years we have witnessed an emergence of cloud computing services, in all important fields. These services provide space for keeping huge amount of data, and also great computational power. But together with these huge benefits, some privacy concerns are raised, about how much trust could we have in the provided services. A solution to this problem comes from the perspective of using homomorphic encryption to store and process data in an encrypted form. In this paper, we present the implementation of a speaker recognition system, which preserves the privacy of the K known speaker models used for identification. Our approach uses for homomorphic operations the homomorphic library SEAL and a larger plaintext space, avoiding the large amount of ciphertexts caused by bit-wise encryption.
Drowsiness Detection Using Eye Blink and Facial Features Image Analysis

Drowsiness detection and alert system is developed using OpenCV library and deep learning algorithms andimplemented with a night vision camera and a computer to detect if a person is drowsy. The system uses acamera to capture the person’s face and eyes to detect fatigue. In such a case where fatigue is detected, awarning signal is issued to alert the person and an SMS to a person related to the victim
Chaotic Resonance in Forced Chua's Oscillators

Stochastic resonance (SR) is a phenomenon in which dynamic noise is effectively used to induce state transitions in a double-well potential system driven by subthreshold input signals. The noises are supplied to the system as an additional force. Recently, a phenomenon called “chaotic resonance” (CR) has been spotlighted in the literature. CR can be observed in chaotic systems that have multiple strange attractors and the ability to accept subthreshold input signals; i.e., such CR systems do not require any external noise source, unlike traditional SR systems. In this study, we employed Chua’s oscillator as a candidate CR system. The oscillator was driven by a sinusoidal voltage source providing subthreshold input signals. In a certain range of input signal frequencies, we observed chaotic state transitions between the two attractors, whereas no state transition between the attractors was observed in the remaining frequency range. These findings indicated that chaotic fluctuations assisted the state transition. Furthermore, we observed nonmonotonic CR characteristics (correlation value and signal-to-noise ratio between the input signal and the output signal) that corresponded to typical nonmonotonic SR curves.