Miracle-dz/UniFAR-FTUs huggingface dataset:
Just‐in‐time rescue plerixafor in combination with chemotherapy and granulocyte‐colony stimulating factor for peripheral blood progenitor cell mobilization

Plerixafor, a recently approved peripheral blood progenitor cell mobilizing agent, is often added to granulocyte‐colony stimulating factor (G‐CSF) to mobilize peripheral blood progenitor cells in patients with lymphoma or myeloma who cannot mobilize enough CD34+ cells with G‐CSF alone to undergo autologous stem cell transplantation. However, data are lacking regarding the feasibility and efficacy of just‐in‐time plerixafor in combination with chemotherapy and G‐CSF. We reviewed the peripheral blood stem cell collection data of 38 consecutive patients with lymphoma (Hodgkin's and non‐Hodgkin's) and multiple myeloma who underwent chemomobilization and high‐dose G‐CSF and just‐in‐time plerixafor to evaluate the efficacy of this treatment combination. All patients with multiple myeloma and all but one patient with lymphoma collected the minimum required number of CD34+ cells to proceed with autologous stem cell transplantation (>2 × 106/kg of body weight). The median CD34+ cell dose collected in patients with non‐Hodgkin lymphoma was 4.93 × 106/kg of body weight. The median CD34+ cell dose collected for patients with multiple myeloma was 8.81 × 106/kg of body weight. Plerixafor was well tolerated; no grade 2 or higher non‐hematologic toxic effects were observed. Am. J. Hematol. 88:754–757, 2013. © 2013 Wiley Periodicals, Inc.
Understanding alexithymia and language skills in children: implications for assessment and intervention.

PURPOSE This article reviews the construct of alexithymia and its relationship to language impairment. METHOD The article includes a review of the literature on emotional competence, trauma effects, alexithymia, and language impairment; summarizes tools to assess alexithymia; and provides an intervention framework. IMPLICATIONS Understanding the relationship of emotional competence and language impairment may provide a new perspective for speech-language pathologists who are serving children with language and socioemotional impairments.
Comparaison d'algorithmes de construction de hiérarchies de classes

Plusieurs algorithmes ont ete proposes pour la construction de hierarchies de classes a partir de la specification de leurs proprietes. Entre autres, les algorithmes proposes dans (Dicky, Dony, Huchard & Libourel, 1994) et (Godin, Mineau & Missaoui, 1995a) preservent la structure de sous-hierarchie de Galois de la relation entre les classes et leurs proprietes. De plus ces algorithmes peuvent incorporer de nouvelles classes a une hierarchie existante. Le resultat est une hierarchie qui garantie la factorisation maximale des proprietes et la conformite avec la relation de specialisation entre les classes. Les deux algorithmes ont ete implementes dans un environnement commun afin de comparer leurs performances. Les resultats d’experiences sont rapportes et analyses.
Stability of leisure‐time physical activity during adolescence—a longitudinal study among 16‐, 17‐ and 18‐year‐old Finnish youth

Participation in physical activity during childhood and adolescence is frequently mentioned as one factor likely to promote a more active lifestyle in adulthood with its health benefits. We studied the changes in leisure‐time physical activity pattern and self‐reported fitness during a three‐year period in adolescence and investigated whether the type of sports has an effect on stability of physical activity at leisure. A questionnaire with identical physical activity items was sent to Finnish twins on their 16th and 17th birthdays and 6 months after the 18th birthday. A total of 1338 boys and 1596 girls responded to all three questionnaires, with response rates of 73.6% and 86.5%. The proportions of very active adolescents and adolescents with very good self‐reported fitness seem to be alike at each age. Among girls, 23.7% to 27.7% reported being very active (4–5 times a week) and 13.7% to 15.1% considered their physical fitness to be very good at the ages of 16, 17 and 18. Among boys, the comparable percentages were 31.5% to 35.5% and 30.6% to 34.4%. However, the longitudinal three‐year follow up showed substantial changes over time among individuals from one physical activity group to another. Only 19.1% of boys and 11.2% of girls were persistent exercisers (i.e., very active on all three years) and 15.6% of boys and 5.1% of girls were persistently fit (i.e., very good self‐reported fitness on all three years). Stability of leisure‐time physical activity was highest among those who participated in several different types of sports. Among boys the proportion of persistent exercisers was highest for those who participated in cross‐country skiing, jogging and body‐building (22.0–41.5%) and among girls for those who participated in ball games (11.9–28.6%). Those who participated in organised sports were more often persistent exercisers than those who did not (odds ratio = 13.2 for boys (CI 9.4–18.7) and 8.9 for girls (CI 6.4–12.5)). Also, those who participated in organised sports were more often persistently fit (odds ratio = 7.3 for boys (CI 5.2–10.2) and 10.4 for girls (CI 6.4–16.9). Adolescents are recommended to participate in and try different types of sports, and especially for girls ball games would appear to favour long‐term maintenance of leisure‐time physical activity.
Significance of prior percutaneous revascularisation in patients with acute coronary syndromes: insights from the prospective PROSPECT registry.

AIMS Prior percutaneous coronary intervention (PCI) is increasingly encountered in acute coronary syndrome (ACS) patients, with uncertain significance. We sought to evaluate the impact of prior PCI in ACS patients. METHODS AND RESULTS Patients with ACS enrolled in the prospective PROSPECT registry underwent three-vessel intravascular ultrasound and virtual histology evaluation after successful PCI of the culprit lesion(s). We identified patients with prior PCI (>6 months before index ACS) and compared their outcomes to those without prior PCI. Time-to-event for major adverse cardiac events (MACE) was estimated up to three years, and the independent association between prior PCI and MACE was evaluated in a multivariable model. Among 696 patients enrolled, 77 (11.1%) had prior PCI. They were older and more likely to have prior myocardial infarction, chronic kidney disease, and congestive heart failure. At three years, patients with prior PCI had significantly higher rates of cardiac death, rehospitalisation for worsening angina, and MACE (adjusted HR=1.73 [95% CI: 1.09, 2.75], p=0.02), independent of other comorbidities and intravascular ultrasound findings. CONCLUSIONS Prior PCI was noted in over 10% of patients with ACS and was associated with higher mortality and morbidity, independent of other comorbidities. Prior PCI should be considered a high-risk feature when evaluating ACS patients.
From Digitization to Knowledge: Resources and Methods for Semantic Processing of Digital Works/Texts

Wikipedia and related projects such as Wiktionary are widely used as resources for solving various tasks in Natural Language Processing and Computational Linguistics. In the area of semantics, this relates, for example, to explicit semantic analysis and topic labeling as well as to wikification, ontology mining, merging and enrichment. A central prerequisite of any such endeavor is the accurate and detailed pre-processing of these resources along such tasks as automatic tagging of parts of speech and grammatical categories, disambiguation, dependency parsing, relation extraction and topic modeling. In this talk, I will address these tasks by example of the German Wikipedia. The aim is to show how they scale with the size of Wikipedia subject to its growth over time. This is done as a prerequisite for studying laws of semantic change by analyzing several consecutive stages of Wikipedia thereby giving insights into the time and space complexity of time-related lexical-semantic analyses. This is done from the point of view of complex network theory. We show the dependency of the entropy of lexical networks derived from Wikipedia as a function of time. This is done to get sparse representations of vector embeddings to be used for the various tasks of semantic modeling. A special focus will be on visualizing the output of such analyses with the help of the TextImager. The UIMA-based TextImager automatically extracts a wide range of linguistic information from input texts to derive representational images of these texts.
FACE PAIRING GRAPHS AND 3-MANIFOLD ENUMERATION

The face pairing graph of a 3-manifold triangulation is a 4-valent graph denoting which tetrahedron faces are identified with which others. We present a series of properties that must be satisfied by the face pairing graph of a closed minimal ℙ2-irreducible triangulation. In addition we present constraints upon the combinatorial structure of such a triangulation that can be deduced from its face pairing graph. These results are then applied to the enumeration of closed minimal ℙ2-irreducible 3-manifold triangulations, leading to a significant improvement in the performance of the enumeration algorithm. Results are offered for both orientable and non-orientable triangulations.
Genetic algorithm based signal optimizer for oversaturated urban signalized intersection

Relieving traffic congestion is an urgent call for traffic engineering. Although various adaptive control strategies have been reported in literature to reduce the travel delay, most of them are not tested under oversaturated condition, where the traffic demand is higher than the road capacity. Therefore, this work proposes genetic algorithm (GA) to optimize the traffic signals for reducing the average delay at the at-grade crossed intersection under oversaturated condition. A comprehensive traffic model has been developed as the testbed. The average delay experienced by every vehicle to traverse the intersection is taken as performance metric to evaluate the performances of the formulated GA. The simulation results show the formulated GA is able to optimize the traffic signals and minimize the average delay of the intersection to 55.2 sec or equivalent to level-of-service (LOS) D.
Economic consequences of preterm birth and low birthweight

The high rates of mortality and morbidity arising from preterm birth and low birthweight impose an immense burden on the health, education and social services and on families. This was evaluated in several economic studies published in the 1970s and early 1980s, but an ability to intervene effectively to increase survival has transformed neonatal care over the past two decades. In addition, the relative prices of resource inputs are vastly different. This paper surveys the scientific literature on the economic consequences of preterm birth and low birthweight, including: (1) studies, which estimate the economic costs of the conditions and (2) economic evaluations of primary and secondary prevention and treatment strategies. This paper summarises the scope and scientific quality of the published evidence, identifies gaps in our knowledge and considers the future research agenda in this area.
Coherent broadband continuous-wave terahertz spectroscopy on solid-state samples

Measuring the complex dielectric function ε(ω)=ε1+iε2 of solid-state samples in the terahertz frequency range with high spectral resolution remains difficult. Using a continuous-wave terahertz spectrometer based on photomixing in the frequency range from 60 GHz to 1.8 THz, we obtain the most precise data of ε(ω) reported to date for the well-studied example of α-lactose monohydrate. We are able to determine both ε1 and ε2 due to coherent detection and show that the results are Kramers–Kronig consistent. Our analysis is based on scanning an interference pattern in frequency and relies on the high spectral resolution in the MHz range. This enables us to avoid mechanically moving parts such as a delay stage. Moreover, we show that the optical data can be used to determine both ε(ω) and the sample thickness d independently.
Tuberculous meningitis: a report of 60 adult cases.

OBJECTIVE This was to evaluate the history, clinical and laboratory findings, outcome and prognosis of patients with tuberculous meningitis (TBM). METHOD Between 1998 and 2009, 60 patients with TBM were evaluated, retrospectively. RESULTS Overall, 60 patients were selected, of which 33 (55%) were male. The patients' ages ranged from 14 to 62 years. In the majority of the patients, disease was in an advanced stage on admission (66% in stage III according to the British Research Council neurological criteria). The rate of complications was highest among patients in stages II and III with an overall mortality rate of 6.6% (n = 2 of stage II patients and n = 2 of stage III patients). CONCLUSIONS Earlier admission of the patients with TBM could provide better outcomes with regard to sequelae and mortality. Fatal cases presented with rapid deterioration and were refractory to treatment.
Vascular access results from the Dialysis Outcomes and Practice Patterns Study (DOPPS): performance against Kidney Disease Outcomes Quality Initiative (K/DOQI) Clinical Practice Guidelines.

BACKGROUND The Kidney Disease Outcomes Quality Initiative Guidelines for Vascular Access in hemodialysis patients recommend native arteriovenous (AV) fistulae over AV grafts or catheters for permanent vascular access. They recommend letting fistulae mature > or =1 month before cannulation. METHODS The Dialysis Outcomes and Practice Patterns Study (DOPPS) provides an unparalleled means to examine vascular access practice patterns and guidelines internationally, with particular attention to associations with mortality risk. RESULTS Most patients in Europe and Japan dialyze through AV fistulae and very few use AV grafts; in the United States, more patients use grafts than fistulae. Patients who receive nephrologic care for over 30 days before starting dialysis have significantly higher chances of commencing via AV fistula. Medical directors of dialysis facilities in the United States commonly prefer grafts; in Europe and Japan, most prefer fistulae. In the United States, there is a relatively long average time between fistula creation and cannulation but significantly worse fistula survival than that seen in Europe. Tunneled catheters pose a higher mortality risk than permanent accesses and are associated with increased risk of failure of a subsequent fistula. The percentage of prevalent patients in the DOPPS countries using catheters has increased in recent years. DOPPS data suggest that performance in some countries falls short of practices achieved in other countries. AV fistula use is low in the United States but has been improving. The trend of increasing use of catheters in most countries is discouraging. CONCLUSION The DOPPS will continue to monitor practice trends and explore whether greater application of guidelines will lead to fewer access complications and improved longevity for hemodialysis patients.
High fat diet blunts the effects of leptin on ventilation and on carotid body activity

Leptin plays a role in the control of breathing, acting mainly on central nervous system; however, leptin receptors have been recently shown to be expressed in the carotid body (CB), and this finding suggests a physiological role for leptin in the regulation of CB function. Leptin increases minute ventilation in both basal and hypoxic conditions in rats. It increases the frequency of carotid sinus nerve discharge in basal conditions, as well as the release of adenosine from the CB. However, in a metabolic syndrome animal model, the effects of leptin in ventilatory control, carotid sinus nerve activity and adenosine release by the CB are blunted. Although leptin may be involved in triggering CB overactivation in initial stages of obesity and dysmetabolism, resistance to leptin signalling and blunting of responses develops in metabolic syndrome animal models.
Modeling and Dynamic Simulations of Doubly Fed Adjustable-Speed Pumped Storage Units

This paper derives the mathematical models of doubly fed adjustable-speed pumped storage units (DFASPSUs) to be utilized in the power system analysis. It adopts the improved induction machine model with ac excitation on the wire-wound rotor as well as the field-oriented control theory for the study and analysis of DFASPSU models. First, the rotor excitation voltage is separated into two components, i.e., the q-axis voltage and the d-axis voltage, so as to control the output active and reactive powers, respectively. Next, a dynamic model of DFASPSU is derived using the swing equation of rotary electric machine and the equation of motion of rotor rotating mass. Finally, computer simulation is carried out to compare its results with practical examples in terms of dynamic characteristics for verifying the correctness of the proposed models.
Treatment of primary liver cancer.

OBJECTIVE To evaluate treatment of patients with primary liver cancer. DESIGN Prospective protocol including subsets of randomised studies. SETTING University hospital, Sweden. SUBJECTS 123 patients with primary liver cancer. INTERVENTIONS 64 patients underwent hepatic resection, 25 were included in a trial of adjuvant chemotherapy. 24 further patients whose tumours were not resectable were included in a trial of intra-arterial infusion of doxorubicin. MAIN OUTCOME MEASURES Survival and postoperative morbidity. RESULTS The median survival time for patients who had had resections was 11 months (range 0-111). Twelve per cent survived more than 5 years. No prognostic factor had any significant effect on outcome. The postoperative mortality was 11% (7/64). The patients allocated to adjuvant chemotherapy survived a median of 10 months (range 1-47) and the controls 29 months (range 8-111) (p=0.04). Patients with unresectable liver cancer treated with intra-arterial doxorubicin lived no longer than untreated controls (median 8 months (range 1-56) compared with 7 months (range 1-28)). CONCLUSIONS Treatment of patients with primary liver cancer is still an unsolved problem. Adjuvant chemotherapy with doxorubicin had no beneficial effect on survival.
Applying Probability Model to The Genetic Algorithm Based Cloud Rendering Task Scheduling

There are huge amount of tasks and data to be processed in cloud rendering environment. How to effectively schedule them is the key to ensure the overall performance of the cloud rendering environment. In this paper, an improved task scheduling algorithm based on genetic algorithm (PMGA) and probability model is proposed, which aims to minimize the total time and cost of task scheduling . First, the fitness function relating to the total time and task cost is improved under the consideration of the user’s satisfaction to the rendering services. Then, a probability model is constructed for the scheduling algorithm, which is used to achieve the non-linear adaptive adjustment of the crossover rate function and the mutation rate function. As a result, the evolutionary ability of poor individuals in the population can be enhanced, avoiding the stagnation in the early stages. Finally, experiments are performed to demonstrate that PMGA has a better ability of optimization than that of traditional adaptive genetic algorithm (AGA). Our approach contributes to reduce the total time and the scheduling cost of the cloud rendering tasks. Keywords-Cloud Rendering; Task scheduling; Genetic Algorithm; The Fitness Function; Probability Model; The Crossover Rate; The Mutation Rate
The KEY to the end of chemotherapy in non-small cell lung cancer?

Until recently, advances in the treatment of non-small cell lung cancer (NSCLC) has been with the use of molecular targeted therapy in tumors harboring oncogenic drivers such as epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) or ROS1 gene rearrangement (1-3). However, a majority of non-Asian NSCLC do not harbor an actionable driver oncogene (4) and a platinum doublet with or without bevacizumab is still the standard of care in the first line setting (5).
Thermal and spin-torque noise in CPP (TMR and/or GMR) read sensors

This paper considers magnetization fluctuations (mag-noise) in current-perpendicular-to-plane (CPP) read sensors, due to either thermal fluctuations or spin-torque induced instability. The former are relevant to both tunneling (TMR) and giant-magnetoresistance (GMR) devices, the latter a potentially more serious limitation most relevant to all-metal GMR sensors. Discussion of thermal mag-noise is here treated by micromagnetic simulation. Discussion of spin-torque instability includes analytical modeling combined with experimental measurements.
Role of Penicillin-Binding Protein 4 in Expression of Vancomycin Resistance among Clinical Isolates of Oxacillin-ResistantStaphylococcus aureus

ABSTRACT It has been reported that penicillin-binding protein 4 (PBP4) activity decreases when a vancomycin-susceptibleStaphylococcus aureus isolate is passaged in vitro to vancomycin resistance. We analyzed the PBP profiles of four vancomycin intermediately susceptible S. aureus (VISA) clinical isolates and found that PBP4 was undetectable in three isolates (HIP 5827, HIP 5836, and HIP 6297) and markedly reduced in a fourth (Mu50). PBP4 was readily visible in five vancomycin-susceptible, oxacillin-resistant S. aureus (ORSA) isolates. The nucleotide sequences of the pbp4 structural gene and flanking sequences did not different between the VISA and vancomycin-susceptible isolates. Overproduction of PBP4 on a high-copy-number plasmid in the VISA isolates produced a two- to threefold decrease in vancomycin MICs. Inactivation ofpbp4 by allelic replacement mutagenesis in three vancomycin-susceptible ORSA strains (COL, RN450M, and N315) led to a decrease in vancomycin susceptibility, an increase in highly vancomycin-resistant subpopulations, and decreased cell wall cross-linking by high-performance liquid chromatography analysis. Complementation of the COL mutant with plasmid-encodedpbp4 restored the vancomycin MIC and increased cell wall cross-linking. These data suggest that alterations in PBP4 expression are at least partially responsible for the VISA phenotype.
Interaction of hydrogen sulfide with ion channels

1. Hydrogen sulfide (H2S) is a signalling gasotransmitter. It targets different ion channels and receptors, and fulfils its various roles in modulating the functions of different systems. However, the interaction of H2S with different types of ion channels and underlying molecular mechanisms has not been reviewed systematically.
Effective Systems: Overcoming the Obstacles

The study on which this paper is based started with the hypothesis that many of the implementation problems met in introducing new information systems. or in making use of new IT-based tools, stem from social and organizational factors rather than from shortcomings in the technology itself. Prior studies, such as the Tavistock Institute's classic study of productivity changes in the coal mining industry (Trist et al., 1963), and Woodward's studies in the 1960s (Woodward, 1965) had indicated dearly that organizational and social issues had a significant effect on the level of success obtained in utilizing new technology in the workplace. A prior study carried out by one of the authors (Land et al., 1983) had indicated that within a single organization the same system introduced into a number of different locations yielded widely different degrees of implementation success. That study suggested that a critical factor in success is the extent to which those who sponsor and champion the system share values with those who use or operate the system. Other studies (Heath, 1988) have suggested that a necessary condition for successful implementation is the presence of a 'product champion'.