Miracle-dz/UniFAR-FTUs huggingface dataset:
Transformation‐specific matrix metalloproteinases (MMP)‐7 and MMP‐13 are expressed by tumour cells in epidermolysis bullosa‐associated squamous cell carcinomas

Background Patients with recessive dystrophic epidermolysis bullosa (RDEB) have an increased risk of developing rapidly progressive and metastatic cutaneous squamous cell carcinomas (SCC). It is unclear why these SCC behave more aggressively than sporadic SCC. Matrix metalloproteinases (MMP) are a family of endopeptidases that contribute to growth, invasion and metastasis of SCC. The role of MMP in RDEB‐associated SCC is not known.
Design Methodologies for Low-Power CMOS Operational Amplifiers in a 0.25μm Digital CMOS Process

Operational amplifiers (op-amps) have proven to be indispensable because of their various applications in the field of electronics. Industrial specifications of op-amps have been continuously improving in almost every metric. This paper discusses the design methodologies developed for standalone, low-power, all-complementary metal-oxide semiconductor (CMOS) op-amps targeting industry-standard specification using two basic op-amp topologies. These design methods were developed from previous theses done at the laboratory and from other universities' publications
Osseous variations of the hypoglossal canal area.

BACKGROUND The hypoglossal canal is a paired bone passage running from the posterior cranial fossa to the nasopharyngeal carotid space. Hyperostotic variations of this structure have been described. MATERIAL/METHODS One hundred sixteen adult cadaveric dried skull specimens were analyzed. Several canal features, dimensions, and distances relative to constant and reliable landmarks were recorded. RESULTS One osseous spur in the inner or outer orifice of the canal was present in 18.10% of specimens (42/232). Two or more osseous spurs were evident in 0.86% of specimens (2/232). However, complete osseous bridging, in the outer or inner part of the canal, was evident in 19.83% of specimens (46/232). Osseous bridging extending through the entire course of the canal was visible in 1.72% of the specimens (4/232). The mean lateral length of the canal was 10.22 mm, the mean medial length was 8.93 mm, the mean transverse and vertical diameters of the internal orifice were 7.44 mm and 4.42 mm, respectively, and the mean transverse and vertical diameters of the external orifice were 6.15 mm and 3.91 mm, respectively. The mean inclination of single hypoglossal canals was 42.3 degrees and 32.4 degrees on the right and left side, respectively. CONCLUSIONS A detailed and accurate evaluation of the hypoglossal canal topographic anatomy with regard to specific, standard osseous landmarks was performed. Additional data with respect to several morphologic features of the hypoglossal canal area also was obtained. Results of this study provide important information that will enable effective and reliable surgical intervention in the area of the hypoglossal canal.
Vascular disease and cognitive function in older men in the Caerphilly cohort.

OBJECTIVES Stroke can impair cognitive function, but the associations between other manifestations of vascular disease and cognitive function have not been adequately studied in representative population samples of subjects. We report the associations between cardiac and peripheral vascular disease and cognitive function for a large representative sample of men in Caerphilly, South Wales, UK. DESIGN The Caerphilly cohort is the basis of on-going studies of vascular disease, of cognitive function and of predictors of these. We have made intensive attempts to identify all cases of vascular disease: myocardial infarction, angina, ECG ischaemia, peripheral vascular disease (intermittent claudication) and stroke. Here we present data on associations between vascular disease and cognitive function. SETTING The study is based upon a representative population sample of over 1,500 men in South Wales, aged 55-69 years when cognitive function was measured. The men, and hospital and GP notes relating to them, had been repeatedly examined for evidence of vascular disease during the previous ten years. MAIN OUTCOME MEASURES Standard tests of cognitive function: the AH4, CAMCOG, MMSE and choice reaction time. RESULTS After the omission of men who had had a stroke, we detected significant associations between cognitive function and the presence of angina, ECG ischaemia, past myocardial infarction and intermittent claudication. The strength of the associations between cognitive function and the various manifestations of vascular disease were similar, and the various cognitive function tests showed effects of similar size. Overall, cardiac and peripheral vascular disease is associated with a significant reduction in cognitive function equivalent to about one sixth of the standard deviation of a number of tests of cognitive function. The size of this effect is roughly equivalent to the decline in cognitive performance over five years of ageing. CONCLUSIONS Subjects with evidence of cardiac or peripheral vascular disease have on average a significant reduction in cognitive function equivalent to about four or five years of additional age. The effect of long-term, low-dose aspirin on cognitive decline should now be tested.
Document-Centric Mixed Reality and Informal Communication in a Brazilian Neurological Institution

We present initial designs toward a system facilitating ad hoc communication among staff in a large chronic care hospital for patients with neurological disorders and brain injury. We identify unique characteristics of the hospital and its context, and we discuss potential benefits of employing document-centric mixed reality as a means of enhancing the informal communication practices that support hospital workflow. Author
Phosphonomethoxyalkyl analogs of nucleotides.

Acyclic nucleoside phosphonates (ANP) are analogs of nucleotides exhibiting various biological (e.g. antiviral, cytostatic, antiparasitic, immunomodulatory) activities. This review describes synthetic approaches to their preparation, biological activities, structure-activity relationships and mode of action of ANPs, with emphasis to selected drugs or drug candidates. Three compounds of the ANP group (cidofovir, adefovir, tenofovir) are active components of potent antivirals approved for therapeutic use in human medicine aimed at hepatitis B, AIDS and various diseases caused by DNA viruses.
G-Estimation of the Effect of Prophylaxis Therapy for Pneumocystis carinii Pneumonia on the Survival of AIDS Patients

AIDS Clinical Trial Group Randomized Trial 002 compared the effect of high-dose with low-dose 3-azido-3-deoxythymidine (AZT) on the survival of AIDS patients. Embedded within the trial was an essentially uncontrolled observational study of the effect of prophylaxis therapy for pneumocystis carinii pneumonia on survival. In this paper, we estimate the causal effect of prophylaxis therapy on survival by using the method of G-estimation to estimate the parameters of a structural nested failure time model (SNFTM). Our SNFTM relates a subject's observed time of death and observed prophylaxis history to the time the subject would have died if, possibly contrary to fact, prophylaxis therapy had been withheld. We find that, under our assumptions, the data are consistent with prophylaxis therapy increasing survival by 16% or decreasing survival by 18% at the a=0.05 level. The analytic approach proposed in this paper will be necessary to control bias in any epidemiologic study in which there exists a time-dependent risk factor for death, such as pneumocystis carinii pneumonia history, that (Al) influences subsequent exposure to the agent under study, for example, prophylaxis therapy, and (A2) is itself influenced by past exposure to the study agent. Conditions A1 and . 42 will be true whenever there exists a time-dependent risk factor that is simultaneously a confounder and an intermediate variable. (Epidemiology 1992;3:319–336)
Precognitive control: open- and closed-loop steering in a lane-change manoeuvre.

Abstract This paper presents two experiments in which steering a lane-change manoeuvre is analysed as a precognitive control task. The suggestion that the dependence on instantaneous visual feedback is low during such a task was tested by analysing steering performance under conditions both with and without visual occlusion. Steering force served as the main independent variable in experiment I, which was performed in a fixed-base driving simulator. A 1 s visual occlusion period during the initial steering-wheel movement to the left was given every other manoeuvre. The results indicate that steering force reduces steering-wheel amplitude variability, this effect also being reflected in the maximum heading angle variability. Steering-wheel angle amplitude was the main independent variable in experiment II, which was carried out in the instrumented car. In this experiment the duration of the occlusion period was 3 s, i.e. covering the complete pull-out phase of the manoeuvre. The results show that variabili.
The influence of abnormal hip mechanics on knee injury: a biomechanical perspective.

UNLABELLED During the last decade, there has been a growing body of literature suggesting that proximal factors may play a contributory role with respect to knee injuries. A review of the biomechanical and clinical studies in this area indicated that impaired muscular control of the hip, pelvis, and trunk can affect tibiofemoral and patellofemoral joint kinematics and kinetics in multiple planes. In particular, there is evidence that motion impairments at the hip may underlie injuries such as anterior cruciate ligament tears, iliotibial band syndrome, and patellofemoral joint pain. In addition, the literature suggests that females may be more disposed to proximal influences than males. Based on the evidence presented as part of this clinical commentary, it can be argued that interventions which address proximal impairments may be beneficial for patients who present with various knee conditions. More specifically, a biomechanical argument can be made for the incorporation of pelvis and trunk stability, as well as dynamic hip joint control, into the design of knee rehabilitation programs. LEVEL OF EVIDENCE Aetiology/therapy, level 5.
Transient radiation of system of four noncollinear dipoles

The transient excitation of four dipoles in a plane that form rhombus is considered. The problem is solved in time domain by vector potential method. The radiated transient field is compared with the field of a single dipole with doubled excitation current and bigger length. It is considered the appearance and behavior of new components of the vector radiated field.
Prolonged ischemia increases severity of rejection in skin flap allotransplantation in rats

To investigate the relationship between ischemic time and rejection against allotransplants, vascularized cutaneous flaps from the groin of Brown Norway rats were transplanted to Lewis rats. The ischemic time was set at 1 hour and 6 hours for comparison. Cycrosporine A was used as the immunosuppressant. The results showed more severe rejection in the 6 hours ischemic time group in vivo, and in vitro examination using mixed lymphocyte reaction assay also demonstrated a greater antidonor response in 6 hours‐ischemic group than that in 1 hour‐group. Immunohistochemical study demonstrated more MHC class II antigen expression in 6 hours‐ischemic group than in 1 hour‐group. These results suggest that longer ischemic time induces more severe rejection against allo‐transplanted tissue compared with the shorter one through an upregulation of MHC class II antigen. It is expected that these findings contribute to the studies for investigating the mechanism of rejection against the allo‐transplants. © 2010 Wiley‐Liss, Inc. Microsurgery 2010.
Grand Challenge: Runtime Anomaly Detection Method in Smart Factories using Machine Learning on RDF Event Streams

This year’s ACM DEBS Grand Challenge problem is about anomaly detection of manufacturing equipments based on machine learning techniques, which is fairy challenging. This requires semi-realtime handling of RDF data values continuously collected in streams, measured from analog sensors attached to multiple machines. This paper shows our experience in implementing solutions of the problems in this domain. It includes our elaboration on high degree of concurrency in continuous query processing, to make better use of distributed environments provided by docker containers. CCS CONCEPTS • Information systems→ Data stream mining; Resource Description Framework (RDF); Clustering;
Analysis of tissue dependent DNA yield for optimal sampling of micro-moths in large-scale biodiversity surveys.

DNA barcoding surveys of small insects usually extract DNA from either a complete insect or a leg. Little is known about how to optimize DNA quantity and quality from different insect parts while preserving a morphological voucher. Here, we quantify DNA yield from different body parts (antenna, hind leg, forewing, hind wing and abdomen) of the micro-moth Cameraria ohridella (Lepidoptera: Gracillariidae) using fluorescent nucleic acid stain (PicoGreen). Samples were preserved in 100% ethanol or dried for three weeks. Our experiment was designed to encompass practical sampling options during fieldwork. DNA quality was assessed by PCR amplification of the mitochondrial COI barcode fragment. In addition, we compared PCR amplification using Platinum® Taq and Qiagen DNA Polymerase and quantified sequence success of amplified DNA. We show that overall, dry parts showed higher eluted DNA yields. PCR and sequencing success rate were slightly higher for dry tissue than ethanol-preserved parts. We also show that Platinum® Taq yielded the highest PCR success rate and that all dry tissues are sequenceable. The optimal strategy for DNA barcoding surveys is therefore to mount micro-Lepidoptera specimens in the field for morphological analysis and sample tissues (hind legs are favoured) from dried samples at a later time (several weeks) in the lab for DNA barcoding using preferentially Platinum® Taq. If larger amounts of DNA are required (i.e. for nuclear gene sequencing), several legs from one side of the specimen or the abdomen should be preserved in pure ethanol.
Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis

The present study was undertaken to elucidate germ line mutations of the base excision repair gene, MUTYH, in Japanese patients with adenomatous polyposis. We screened germ line mutations of adenomatous polyposis coli (APC) gene and MUTYH in 66 Japanese patients with adenomatous polyposis. APC was screened by the protein truncation test, while MUTYH was screened by polymerase chain reaction‐based single‐strand conformation polymorphism and direct sequencing. The nicking assay was applied in order to evaluate the DNA glycosylase activity of the identified MUTYH variant. In this study, Seven MUTYH variants were identified in 16 of 21 APC‐negative patients. Q324H mutation was the most frequent mutation, with an allele frequency of 49%. Two patients carried biallelic mutations other than Q324H; a patient had biallelic G272E and A359V mutations, while the other had compound heterozygotes of P18L and G25D mutations. Nicking assay for G272E using the corresponding mouse MUTYH mutant with G257E revealed that G272E is a variant to cause an impaired DNA glycosylase activity. Homozygous MUTYH mutation accounts for approximately 10% of Japanese patients with adenomatous polyposis. G272E may be one of the mutations specific to patients with adenomatous polyposis in East Asia.
Nitrosococcus oceani the marine ammonia oxidizer operon ofamo , in the amoD and amoR Characterization of two new genes

24 Molecular analysis of the amo gene cluster in Nitrosococcus oceani revealed that it consists of 5 25 instead of the three known amoCAB genes. The two additional genes, orf1 and orf5, were 26 introduced as the amoR and amoD genes, respectively. Putative functions of the AmoR and 27 AmoD proteins are discussed. 28 AC CE PT ED July 0, 2010 em . A S M . O R G D O W N LO A D E D F R O M El Sheikh et al. : The amoRCABD operon in nitrosococci 3
A Hyper-Heuristic Approach for MAX-SAT Dalila Boughaci

In this paper, we propose a hyper-heuristic approach for the NP-Hard optimization variant of the satisfiability problem, namely MAX-SAT. A hyperheuristic is a high-level method that incorporates a set of low-level heuristics to handle classes of problems rather than solving one problem. In this paper, we investigate a new selection strategy based on both choice function and randomness to select adequate low-level heuristics at any given time for solving the MAX-SAT problem.
Hardware Efficient Mixed Radix-25/16/9 FFT for LTE Systems

In this paper, we propose a hardware-efficient mixed generalized high-radix (GHR) reconfigurable fast Fourier transform (FFT) processor for long-term evolution applications. The GHR processor based on radix-25/16/9 uses a 2-D factorization scheme as the high-radix unit and a 1-D factorization method as the system data routing technology. The 2-D factorization scheme is implemented by an enhanced delay element matrix structure, which supports 25-, 16-, 9-, 8-, 5-, 4-, 3-, and 2-point FFTs. Two different designs were implemented. One design (called discrete Fourier transform core) supports 34 different transform sizes from 12 to 1296 points, while the other design (called FFT core) supports five different power-of-two sizes from 128 to 2048 points. The 1-D factorization method is performed by a coprime accessing technology, which accesses the data in parallel without conflict using a RAM. The GHR combines 2-D and 1-D factorization techniques and improves the throughput by a factor of two to four with comparable hardware cost compared with the previous designs. The speed-area ratio of the proposed scheme is nearly two times better than that of previous FFT processors. Application-specified integrated circuit implementation results based on a 0.18-μm technology are also provided.
Altruism and the Care of Elderly Parents: Evidence from Japanese Families

This paper analyzes what adult children would do for their parents were they frail and in need of long-term care. Focusing on the special case of parents' illness, the paper then investigates altruism in Japanese children. Descriptive statistics show that about 30% of adult children living separately from their parents provide long-term in-home care, which suggests that a significant number of Japanese children supply care. However, detailed examination reveals that this parental care is not motivated entirely by altruism. We show that children provide parental care when their parents are wealthy enough to meet the costs of nursing.
Dimiconin, a novel coagulation inhibitor from the kissing bug, Triatoma dimidiata, a vector of Chagas disease

SUMMARY Sequence analysis of a Triatoma dimidiata salivary gland cDNA library resulted in the identification of two transcripts (Td60 and Td101) homologous to triabin, an inhibitor of thrombin in Triatoma pallidipennis saliva. In the present study, a recombinant protein of Td60, designated dimiconin, was expressed in Escherichia coli and its activity was characterized. The resulting protein inhibited the intrinsic but not extrinsic blood coagulation pathway, suggesting that dimiconin is not a thrombin inhibitor. Measurement of the enzymatic activity of coagulation factors using chromogenic substrates revealed that dimiconin efficiently inhibited factor XIIa (FXIIa) activity in a dose-dependent manner. In addition, pre-incubation of dimiconin with FXII effectively inhibited FXIIa activity whereas dimiconin did not affect already activated FXIIa, indicating that dimiconin inhibits the activation of FXII but not the enzymatic activity of FXIIa. These results show that dimiconin is an inhibitor of the contact phase initiated by FXII activation in the blood coagulation cascade, which differs from the bioactivity of triabin.
Semantic Measures for the Comparison of Units of Language, Concepts or Entities from Text and Knowledge Base Analysis

Semantic measures are widely used today to estimate the strength of the semantic relationship between elements of various types: units of language (e.g., words, sentences, documents), concepts or even instances semantically characterized (e.g., diseases, genes, geographical locations). Semantic measures play an important role to compare such elements according to semantic proxies: texts and knowledge representations, which support their meaning or describe their nature. Semantic measures are therefore essential for designing intelligent agents which will for example take advantage of semantic analysis to mimic human ability to compare abstract or concrete objects. This paper proposes a comprehensive survey of the broad notion of semantic measure for the comparison of units of language, concepts or instances based on semantic proxy analyses. Semantic measures generalize the well-known notions of semantic similarity, semantic relatedness and semantic distance, which have been extensively studied by various communities over the last decades (e.g., Cognitive Sciences, Linguistics, and Artificial Intelligence to mention a few).
New multimodel aggressive space mapping technique for the efficient design of complex microwave circuits

The well known aggressive space mapping technique has been widely used for the design of complex microwave circuits. Many extensions of ASM have been developed in recent times. These methods improve ASM either at the cost of increasing the number of fine model evaluations, or at the cost of decreasing the accuracy of the fine model. In this work, we present a new extension of ASM, the multimodel ASM (MASM) that uses several fine models of increasing accuracy. Following an iterative procedure, it gradually maps the coarse and the finest model, thus reducing the risk of divergence, and improving the overall efficiency and robustness of the design process, without reducing the accuracy of the results. The new MASM has been tested with the design of a six-pole H plane coupled cavities filter with rounded corners in the coupling windows due to die casting fabrication.
Predicci??n del consumo de coca??na en adolescentes mediante ??rboles de decisi??n

Diversos estudios han comprobado que los rasgos de personalidad juegan un papel importante en el consumo de sustancias adictivas, especialmente en la adolescencia. El objetivo de este trabajo es evaluar el poder predictivo de la impulsividad y la b? squeda de sensaciones sobre el consumo de coca? na, en esta etapa del desarrollo, mediante ? rboles de decisi? n, t? cnicas de Data Mining capaces de representar gr? ficamente la relaci? n entre variables. La muestra estuvo formada por 278 adolescentes (53,2% chicos y 46,8% chicas) de 14 a 18 a? os. Los resultados informan que la impulsividad y la b? squeda de sensaciones predicen tanto la experimentaci? n con la coca? na como el consumo habitual; adem? s, junto con el consumo de alcohol y cannabis, influyen en el n? mero de d? as de consumo de coca? na. Igualmente, se muestra la relaci? n entre el consumo de diferentes sustancias psicoactivas.
Electrografted seed layers for metallization of deep TSV structures

This paper describes electrografted (eG) copper seed layers deposited on a wide range of Through Silicon Via (TSV) dimensions. Deposition is achieved on patterned substrates insulated with different materials (SiO2 for example) and covered by titanium or tantalum based diffusion barriers deposited by PVD, CVD or ALD. This eG technique is fully compatible with standard electroplating tools, either at 200mm or 300mm scale.