Miracle-dz/UniFAR-FTUs huggingface dataset:
Western Pacific coastal sources of iron, manganese, and aluminum to the Equatorial Undercurrent

We present results from the first zonal transect of iron, aluminum, and manganese conducted from the western source region of the Equatorial Undercurrent (EUC) to the central equatorial Pacific. Trace metals were elevated along the slope of Papua New Guinea and within the New Guinea Coastal Undercurrent (NGCU), which is the primary Southern Hemisphere entry path of water to the EUC. Subsurface maxima in total acid‐soluble iron, aluminum, and manganese were evident in the EUC. These maxima were generally greatest in the western equatorial Pacific and decreased in magnitude eastward. Maxima in iron and aluminum persisted to 140°W; maxima in manganese extended to 175°W. Iron and manganese maxima were deeper (25–75 m) than aluminum maxima and located in the lower EUC, which undergoes less interior ocean mixing than shallower waters. The depth of the aluminum subsurface maxima correlated strongly (r = 0.88) with the depth of the EUC velocity maximum. Surface waters were enriched in aluminum and manganese offshore of Papua New Guinea. Surface metal concentrations decreased eastward throughout the western warm pool up to the longitude (∼180°W) of the salinity front. Detrital sediment input from either direct riverine input or sediment resuspension appeared to be the primary mechanism of supplying metals to the NGCU. We estimated eastward fluxes of metals in the EUC and found greatest fluxes in the western equatorial Pacific between 160°E and 165°E, except for aluminum. Fluxes of aluminum and, to a lesser extent, manganese increased concurrently with water volume transport in the central equatorial Pacific. Iron transport in the EUC remained constant east of the dateline, apparently due to the combined effects of dilution by meridional entrainment and scavenging. Iron was mobilized in a highly active western boundary current region and transported eastward in the lower EUC.
Long-term outcome after immunosuppressive therapy with horse or rabbit antithymocyte globulin and cyclosporine for severe aplastic anemia in children

Some prospective studies showed that rabbit antithymocyte globulin was inferior to horse antithymocyte globulin as first-line therapy for patients with severe aplastic anemia. We retrospectively analyzed the clinical outcome of 455 children with severe aplastic anemia who received horse antithymocyte globulin (n=297) or rabbit antithymocyte globulin (n=158) combined with cyclosporine as first-line therapy between 1992 and 2010. The response rates were comparable between the horse and rabbit antithymocyte globulin groups at 3 months [46% (136/294) versus 42% (66/153), P=0.55] and 6 months [60% (178/292) versus 55% (87/143), P=1.0]. Using multivariate analysis, differences in antithymocyte globulin preparations were not associated with response rates. However, 2-year and 10-year overall survival rates in the horse antithymocyte globulin group were significantly better than those in the rabbit antithymocyte globulin group (2-year overall survival: 96% versus 87%, 10-year overall survival: 92% versus 84%, P=0.004). On the basis of multivariate analysis, use of rabbit antithymocyte globulin was a significant adverse factor for overall survival (hazard ratio = 3.56, 95% confidence interval, 1.53 – 8.28, P=0.003). Rabbit antithymocyte globulin caused more profound immunosuppression, which might be responsible for the higher incidence of severe infections. Considering that there are no studies showing the superiority of rabbit antithymocyte globulin over horse antithymocyte globulin, horse antithymocyte globulin should be recommended as a first-line therapy. However, our results justify the use of rabbit antithymocyte globulin as first-line therapy if horse antithymocyte globulin is not available.
Nationwide Statistical Analysis of Lymphoid Malignancies in Korea

Purpose Regional differences in the incidence of lymphoid malignancies have been reported worldwide, but there has been no large-scale epidemiologic analysis in Korea. The aim of this study was to provide a nationwide population-based statistical analysis of Korean patients with lymphoid malignancies. Materials and Methods The Korea Central Cancer Registry analyzed the incidence and survival of patients with lymphoid malignancies from the Korean National Cancer Incidence Database. Diseases were grouped by clinically relevant categories based on the 2008 World Health Organization classification. Results Overall 65,948 lymphoid diseases were identified between 1999 and 2012. The incidence of most subtypes increased with age, except for precursor cell neoplasms. Male predominance (male:female ratio=1.28:1) was observed. In 2012, annual age-standardized incidence rates per 100,000 persons of Hodgkin’s lymphoma, mature B-cell neoplasm, mature T/natural killer (NK)–cell neoplasm, and precursor cell neoplasm were 0.46, 6.60, 0.95, and 1.50, respectively, and they increased yearly from 1999. Composite Hodgkin’s and non-Hodgkin’s lymphomas were extremely rare. Survival improvement estimated using 5-year relative survival rate was observed in patients with Hodgkin’s lymphoma (71.1%-83.0%), diffuse large B-cell lymphoma (49.5%-61.5%), plasma cell neoplasms (20.2%-36.9%), and lymphoblastic lymphoma/leukemia (41.5%-56.3%) between 1993 and 2012. However, survival rates of T/NK-cell lymphoma (excluding cutaneous T-cell lymphoma) ranged from 40.5%-43.5% during the study period. Survival rates decreased with age in most subtypes. Conclusion This report presented the subtype-specific statistical analysis of lymphoid malignancies in the Korean population, showing increasing incidences and survival rates in most subtypes.
Molecular basis of the variable mitochondrial and peroxisomal localisation of alanine-glyoxylate aminotransferase.

The molecular basis of the variable species-specific peroxisomal and/or mitochondrial targeting of the enzyme alanine-glyoxylate aminotransferase 1 (AGT) has been studied in human fibroblasts by confocal immunofluorescence microscopy after intranuclear microinjection of various human, rabbit, marmoset, and feline AGT cDNA constructs. The expression of full-length human and rabbit AGT cDNA led to an exclusively peroxisomal distribution of AGT. However, the distribution of feline and marmoset AGT depended on the cDNA construct injected. In both species, injection of the short cDNAs (from transcripts that occur naturally in marmoset liver but not in feline liver) led to an exclusively peroxisomal distribution. However, injection of the long cDNAs (from transcripts that occur naturally in both species) led to most of the AGT being targeted to the mitochondria and only a small, yet significant, fraction to the peroxisomes. Reintroduction of the 'ancestral' first potential translation initiation site into human AGT cDNA led to an 'ancestral' distribution of AGT (i.e. both mitochondrial and peroxisomal). Deletion of the second potential translation start site from the long feline cDNA led to a distribution that was almost entirely mitochondrial, which suggests that most peroxisomal AGT encoded by the long cDNA results from internal translation initiation from this site with the consequent loss of the N-terminal mitochondrial targeting sequence. Expression of rabbit cDNA and the short marmoset and feline cDNAs in cells selectively deficient in the import of peroxisomal matrix proteins showed that peroxisomal AGT in all these species is imported via the peroxisomal targeting sequence type 1 (PTS1) import pathway. The almost complete functional dominance of the N-terminal mitochondrial targeting sequence over the C-terminal PTS. which was not due to any direct interference of the former with peroxisomal import, was maintained even when the unusual PTS1 of AGT (KKL in human) was replaced by the prototypical PTS1 SKL. The results demonstrate that the major determinant of alanine-glyoxylate aminotransferase subcellular distribution in mammals is the presence or absence of the mitochondrial targeting sequence rather than the peroxisomal targeting sequence. Various strategies have arisen during the evolution of mammals to enable the exclusion of the mitochondrial targeting sequence from the newly synthesised polypeptide, all of which involve the use of alternative transcription and/or translation initiation sites.
Prediction of gap in QFP with unattached heat spreader

Due to cost and process considerations, sometimes the heat spreader of a quad flat package (QFP) is not attached to the die pad. Consequently, due to mismatch of thermal expansions of the components, gapping is inevitable on the unattached interface during temperature change. Presence of the gap would potentially decrease the reliability and thermal performance of QFP. In this paper, contact methodologies were incorporated into finite element models to calculate the distribution of gap on the unattached interface. Both plane two-dimensional and general three-dimensional models were built up and compared for a multi-chip module QFP with a drop-in heat spreader.
CT of the ear in Pendred syndrome.

PURPOSE To prospectively determine the structural anomalies of the inner ear by using thin-section computed tomography (CT) in an extended family with Pendred syndrome. MATERIALS AND METHODS Ethics committee approved the study, and informed consent was obtained from every patient or from parents of patients under legal age. Twelve patients (three females and nine males aged 7-47 years) with Pendred syndrome (all from the same ethnic isolate and with the same mutation in the PDS gene) were evaluated for inner-ear malformation at thin-section CT. Both ears were evaluated. Presence or absence of interscalar septum between upper and middle turns of the cochlea was evaluated, and vestibule and vestibular aqueduct were examined for enlargement. Modiolus was determined to be present or absent (modiolar deficiency). CT scans were evaluated in consensus by two radiologists (M.G., J.M.G.). RESULTS All patients had inner ear malformation on both sides. Modiolus was absent and vestibule was enlarged on both sides in all 12 patients. Interscalar septum was absent in 18 (75%) of 24 ears. In eight patients, interscalar septum was absent in both ears, whereas in two patients, it was absent on only one side. Aqueduct was enlarged in 20 (80%) of 24 ears. In nine patients, both ears had enlarged aqueducts, while in two patients, only one side was abnormal. CONCLUSION Inner ear malformation is an invariable finding in Pendred syndrome. Modiolus deficiency and vestibular enlargement were the most consistent anomalies in this population with Pendred syndrome.
Pasture-associated seasonal respiratory disease in two horses

Two horses on separate farms developed severe obstructive pulmonary disease in successive years during the early summer months. In both cases clinical remission of the respiratory distress was achieved by moving the animals to different environments. The suggested aetiology for this outdoor chronic respiratory disease is a pulmonary allergy to pollen. Both animals were also shown to suffer from classical chronic obstructive pulmonary disease, i.e., obstructive pulmonary disease in the presence of hay and, or, straw.
Restoring tone-Marks in Standard YorùBá Electronic Text: Improved Model

Diacritic Restoration is a necessity in the processing of languages with Latinbased scripts that utilizes letters outside the basic Latin alphabet used by English language. Yoruba is one such languages, marking underdot (dot-below)on three characters and tone marks on all seven vowels and two syllabic nasals. The problem of restoring underdotted characters has been fairly addressed using character as linguistic units for restoration. However, the existing characterbased approaches and word-based approach has not been able to sufficiently address restoration of tone marks in Yoruba. We address in this study tone marks restoration as a subset of diacritic restoration. We proposed using the syllable (derived from word) as the linguistic token for tone marks restoration. In our experimental setup, we used Yoruba text collected from various sources as data with total word count of 250,336 words. These words, on syllabification, yielded 464,274 syllables. The syllables were divided into training and testing data in different proportions ranging from 99% used for training and 1% used for testing to 70% used for training and 30% used for testing. The aim of evaluation different proportions was to determine how the ratio of training-to-test data affect the variations that may occur in the result. We applied Memory-based learning to train the models. We also set up a similar experiment using character token to be able to compare the performance. The result showed that using syllable was able to increase accuracy at word level to 96.23% and an average of almost 15% over that gotten from using character. We also found out that using 75% of data for training and the remaining 25% for testing gives the results with the least variation in a ten-fold cross validation test. Hybridizing the syllable „based approach with other methods like lexicon lookup might likely lead to improvement over the current result.
Improved AdaBoost Algorithm for Robust Real-Time Multi-face Detection

Face detection is the basis for research topics such as face recognition, facial expression recognition and face attribute analysis and it plays a crucial role in the field of computer vision. Traditional methods are difficult to meet the needs of robust real-time multi face detection because of some influencing factors such as head pose, image scene, illumination condition and so on. In this paper, we introduce an intelligent vision algorithm that is able to detect human face from complex scene and filter out all the non-face but face-like images. The human face is detected in real-time environment using the approach called Adaboost-based Haar-Cascade Classifier, and the real human face detection is improved from single-face detection to multi-face detection. In addition, variable head poses are taken into account, such as pitch, roll, yaw, etc. Furthermore, the real-time experiments proved the effectiveness and robustness of the algorithm for human detection we have proposed.
Comparison of an improved rose bengal-chlortetracycline agar with other media for the selective isolation and enumeration of moulds and yeasts in foods.

Summary. A modification of the medium (RBC) of Overcast & Weakley (1969) containing 50 p/m of rose bengal and 10 p/m of chlortetracycline was compared with the oxytetracycline-glucose-yeast extract medium (OGY) of Mossel, Visser & Mengerink (1962) and with acidified (pH 4·5) malt extract agar for the selective isolation and enumeration of moulds and yeasts in foods. The results obtained from several foods confirm earlier observations that media containing antibacterial agents are superior to acidified ones for isolating moulds from foods. Little difference in counts was observed for yeasts on the 3 media and there was no significant difference in the counts of moulds or the incidence of recovery of moulds on the RBC or OGY. Both media suppressed growth of bacteria but the RBC medium restricted the diameter of mould colonies thereby aiding counting and preventing overgrowth of slowly growing strains by more luxuriant species such as occurs on OGY.
Morphological Study of the Sinus Node and Its Artery in Yak

The sinus node of yak has been studied by the histological methods and transmission electron microscopy. The sinus node artery of yak was also determined by the injection‐corrosion casting technique, the angiography, and histological methods. The results showed that the sinus node of yak contained an extensive framework of collagen and two main type cells: pacemaker cells (P cells) and transitional cells (T cells). The P cells had a perinuclear clear zone, contained less myofibrils, and appeared smaller mitochondria than T cells. The T cells were longer and slender than P cells, and had a variety of shapes. At the periphery of sinus node there were many nerve fibers and ganglions. Gap junction did not reveal reaction with anti‐connexin43, but it was detected by electron microscopy in the central part of sinus node of yak. The sinus node artery of yak originated from left coronary artery more frequently (98%) than by right (2%). The artery located at the periphery of sinus node. It had an internal elastic membrane throughout its course, and a large nerve bundle was found running in a longitudinal direction. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
The analog challenge of nanometer CMOS

Nanometer CMOS technology offers the required integration density for advanced products such as home theatre equipment and personal communication devices. The system solutions inside these products demand highly integrated systems-on-silicon, blending high-density digital functions with analog interface circuits. These integrated solutions have to cope with high data-rates, and thus require high speed and high dynamic range circuits, without compromising power consumption. Novel choices on circuit and system level are required to handle the increased number of devices subject to high variability, running at higher intrinsic speeds with a constraint power supply
The central and reflex regulation of the heart rate

THE adaptation of the heart beat to changes in circulatory conditions is attained by two separate mechanisms: (a) by the adaptation of those parts of the central nervous system which regulate the rate and the strength of the cardiac contraction, and (b) by the adaptation of the heart muscle itself. While the rate of a denervated heart remains unaffected by changes in the circulatory conditions and is mainly determined by the temperature of the blood, the rate of the heart in the whole body is influenced in addition by a great number of changes in the mechanical conditions of the circulation. This difference to a large extent is explained by the presence of the extra-cardiac mechanism of adaptation which is lacking in the heart-lung preparation. The use of the whole animal for the study of this mech,nism is not entirely suitable, because it is difficult to control independently the cerebral and the systemic circulation and to decide whether changes in cardiac activity are of central, reflex, or peripheral origin. The different methods of interarterial and arteriovenous crossed circulation which have been introduced to overcome these difficulties do not materially improve the control over the circulation. The newer methods of crossed circulation as used by Anrep and Daly(i), Anrep and Starling(2) and Heymans(3), though they place the cerebral circulation under a better control yet leave the systemic circulation still uncontrolled. The experiments to be described were performed with a new technique which allows an independent control over the circulation in the brain and in the heart. Briefly this technique consists in establishing an innervated heart-lung preparation in contrast to the denervated preparations of Martin(4), Hering() and Starling(6). The innervated heart-lung preparation. Two dogs are used for each experiment. From one dog blood is collected, whilst the second dog is injected with morphia, anasthetised with chloralose (0.075 grm. per kilo), and bled from the femoral artery about one-quarter of its total blood volume. Artificial respiration with room air is started, and the
Expectant management of fetal arm extruding through a large uterine dehiscence following sonographic diagnosis at 27 weeks of gestation

A 25-year-old woman, gravida 4 para 3, presented at our antenatal clinic complaining of abdominal pain at 27 weeks of gestation. The patient’s obstetric history consisted of two normal term deliveries. In her third pregnancy holoprosencephaly was diagnosed and at 26 weeks of gestation feticide was performed followed by hysterotomy due to placenta previa. The uterine incision was low transverse. Ultrasound examination demonstrated a single fetus in breech presentation with an estimated weight of 1030 g and decreased amniotic fluid volume. The cervical length was 35 mm. Midway between the internal os and the uterine fundus, we observed dehiscence of the scar measuring 50 × 26 mm, with a large herniated amniotic sac extending into the maternal abdominal cavity (Figure 1, Videoclip S1). The extrauterine amniotic sac measured 100 × 45 mm and contained most of the amniotic fluid as well as a fetal arm and shoulder. These
Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia

Aim: The aims of this study were: 1) to determine whether the accumulation of aortic root calcification (ARC) assessed using coronary computed tomography angiography (CCTA) can predict future cardiovascular events, and 2) to estimate the onset and progression of ARC in patients with familial hypercholesterolemia (FH). Methods: One hundred thirteen consecutive Japanese patients with heterozygous FH (male = 54, mean age = 52.1 ± 15.6 years, mean LDL-C = 299.0 ± 94.6 mg/dL), without known coronary artery disease, who underwent 64-detector row CCTA were retrospectively evaluated. ARC was defined as the presence of calcium at the aortic root. The extent of ARC was expressed in Agatston units as the ARC-score. Major adverse cardiac events (MACE) were defined as either cardiac death, ST elevated myocardial infarction (STEMI), non-ST elevated myocardial infarction (NSTEMI), unstable angina pectoris (UAP), planned percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or stroke. The periods to MACE were estimated using multivariate logistic regression analysis. Results: During the follow-up period (median 1635 days), 19 instances of MACE occurred. Multivariate logistic regression analysis revealed that ARC was a significant independent predictor of MACE (OR= 1.48; 95% CI 1.11–1.87, p < 0.001, respectively). The regression equations were Y= 0.09X − 1.59 (R2 = 0.34, p < 0.001) in males and Y = 0.08X − 1.60 (R2 = 0.13, p < 0. 05) in females. Conclusions: ARC was significantly associated with future MACE in Japanese patients with heterozygous FH. ARC may start to develop, on average, at 17.4 and 19.7 years of age in males and females, respectively, with heterozygous FH.
In Situ Chemical Characterization of Aged Biomass-Burning Aerosols Impacting Cold Wave Clouds

During the Ice in Clouds Experiment‐Layer Clouds (ICE-L), aged biomass-burning particles were identified within two orographic wave cloud regions over Wyoming using single-particle mass spectrometry and electron microscopy. Using a suite of instrumentation, particle chemistry was characterized in tandem with cloud microphysics. The agedbiomass-burning particles comprised ;30%‐40% by numberof the 0.1‐1.0-mm clear-air particles and were composed of potassium, organic carbon, elemental carbon, and sulfate. Aerosol mass spectrometry measurements suggested these cloud-processed particles were predominantly sulfate by mass. The first cloud region sampled was characterized by primarily homogeneously nucleated ice particles formed at temperatures near 2408C. The second cloud period was characterized by high cloud droplet concentrations (;150‐300 cm 23 ) and lower heterogeneously nucleated ice concentrations (7‐18 L 21 )a t cloud temperatures of 2248 to 2258C. As expected for the observed particle chemistry and dynamics of the observed wave clouds, few significant differences were observed between the clear-air particles and cloud residues. However, suggestive of a possible heterogeneous nucleation mechanism within the first cloud region, ice residues showed enrichments in the number fractions of soot and mass fractions of black carbon, measured by a single-particle mass spectrometer and a single-particle soot photometer, respectively. In addition, enrichment of biomass-burning particles internally mixed with oxalic acid in both the homogeneously nucleated ice and cloud droplets compared to clear air suggests either preferential activation as cloud condensation nuclei or aqueous phase cloud processing.