Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of psychological well-being in retaining rural general practitioners.

OBJECTIVE Retention of rural GPs is an increasing area of concern and is receiving considerable attention from the government, medical authorities and the media. This study aimed to examine the potential for psychological interventions to assist in the retention of rural GPs through targeting their psychological well-being. DESIGN GPs completed a questionnaire, including questions about their level of support in rural practice, psychological health (work-related morale and distress, distress related specifically to working in rural general practice, quality of work life) and intentions to leave rural practice. SETTING Rural general practices in South Australia. PARTICIPANTS One hundred and eighty-seven rural GPs. RESULTS Results indicated that rural GPs who were seriously considering leaving rural practice had higher work-related distress, higher distress related specifically to working in a rural general practice and lower quality of work life. GPs who considered leaving rural practice also reported having fewer colleagues with whom to discuss professional issues. CONCLUSION Results indicated that psychological interventions (such as cognitive behavioural training), assistance with stress reduction and coping mechanisms (such as more interaction with colleagues) may be of benefit to GPs who are considering leaving rural practice. Such training may increase the number of GPs who ultimately stay in rural practice.
MtPAR MYB transcription factor acts as an on switch for proanthocyanidin biosynthesis in Medicago truncatula

MtPAR (Medicago truncatula proanthocyanidin regulator) is an MYB family transcription factor that functions as a key regulator of proanthocyanidin (PA) biosynthesis in the model legume Medicago truncatula. MtPAR expression is confined to the seed coat, the site of PA accumulation. Loss-of-function par mutants contained substantially less PA in the seed coat than the wild type, whereas levels of anthocyanin and other specialized metabolites were normal in the mutants. In contrast, massive accumulation of PAs occurred when MtPAR was expressed ectopically in transformed hairy roots of Medicago. Transcriptome analysis of par mutants and MtPAR-expressing hairy roots, coupled with yeast one-hybrid analysis, revealed that MtPAR positively regulates genes encoding enzymes of the flavonoid–PA pathway via a probable activation of WD40-1. Expression of MtPAR in the forage legume alfalfa (Medicago sativa) resulted in detectable levels of PA in shoots, highlighting the potential of this gene for biotechnological strategies to increase PAs in forage legumes for reduction of pasture bloat in ruminant animals.
Capturing and Integrating Knowledge for Managing Risks in Tunnel Works

Risk‐related knowledge gained from past construction projects is regarded as potentially extremely useful in risk management. This article describes a proposed approach to capture and integrate risk‐related knowledge to support decision making in construction projects. To ameliorate the problem related to the scarcity of risks information often encountered in construction projects, Bayesian Belief Networks are used and expert judgment is elicited to augment available information. Particularly, the article provides an overview of judgment‐based biases that can appear in the elicitation of judgments for constructing Bayesian Networks and the provisos that can be made in this respect to minimize these types of bias. The proposed approach is successfully applied to develop six models for top risks in tunnel works. More than 30 tunneling experts in the Netherlands and Germany were involved in the investigation to provide information on identifying relevant scenarios than can lead to failure events associated with tunneling risks. The article has provided an illustration of the applicability of the developed approach for the case of “face instability in soft soils using slurry shields. ”
Field Test Evaluation of Aerobic, Anaerobic, and Wheelchair Basketball Skill Performances

Forty-six male wheelchair basketball players performed a set of field tests to evaluate aerobic capacity (25 m shuttle run), anaerobic capacity (30s sprint), and six specific wheelchair basketball skills. Overall test-retest reliability (n = 20) ranged from r = 0.65 to r = 0.97. To study the validity (criterion related evidence) of the shuttle run test, heart rate (HR) was recorded for 15 subjects, who also performed a continuous, multistage arm cranking exercise until volitional fatigue. Moderate to high correlations were calculated between shuttle run distances covered (1375 243,6 m) and VO2max (2208+/-461.6 mL/min) and POmax (93.8+/-17.97 W), measured during maximal arm cranking (respectively r = 0.64 and r = 0.87). Maximal HR during shuttle run (174.9+/-16.6 B/min) and arm cranking (169+/-14.21 B/min) were correlated (r = 0.78). High correlations between shuttle run test and anaerobic field tests, however, indicate high implication of anaerobic and wheelchair maneuverability performances. The 30 s sprint test was validated (n = 15) against a Wingate Anaerobic Test (WAnT) on a roller ergometer. Comparing distance (field test: 90+/-6.7 m) with mean power output (WAnT: 852.1+/-234.9 W) the correlation was r = 0.93. Principal components factor analysis identified 'wheelchair propulsion dynamics' and 'eye-hand-coordination' as the underlying constructs of the six skill proficiency measurements, accounting for 80.1% of the variance. In conclusion, the newly developed field test battery is a reliable and valid tool for anaerobic capacity and skill proficiency assessment in wheelchair basketball players.
Aluminum‐associated bone disease in chronic renal failure: High prevalence in a long‐term dialysis population

Twenty‐seven asymptomatic patients treated with hemodialysis longer than 8 years (mean 12.9 ± 3.1 years) underwent bone biopsy to determine the prevalence of aluminum‐associated bone disease. None had excess aluminum exposure from the dialysate. Ten patients (37%) had aluminum‐associated bone disease as defined by a bone formation rate (BFR) below normal in the presence of stainable bone aluminum that covered more than 25% of the trabecular surface. The predominant type of bone histology in this group was the aplastic lesion characterized by low bone turnover, a decreased number of osteoblasts, and lack of excess unmineralized osteoid. Osteoblastic osteoid was highly correlated with stainable surface bone aluminum (r = ‐ .82, p < .001). Among the dynamic bone parameters, the double‐tetracycline labeled surface was a more sensitive indicator of impaired bone function than was the bone apposition rate (BAR), since half of the patients with aluminum‐associated bone disease had a normal BAR. In all of the biopsies the extent of double‐labeled surfaces was inversely proportional to the amount of stainable aluminum on the bone surface (r = ‐ .71, p < .001), whereas stainable bone aluminum did not correlate with BAR. In seven of the patients with aluminum‐associated bone disease, amino‐terminal PTH levels were in the normal range while only one patient had a normal plasma mid‐region PTH. PTH correlated directly with osteoblastic osteoid, BFR, and double‐labeled surfaces. These results indicate that long‐term oral aluminum intake in hemodialysis patients results in a high prevalence of aluminum‐associated bone disease. The decrease in osteoblast number appears to be the major mechanism for the low bone formation. Whether aluminum adversely affects the osteoblast population directly or decreases osteoblast number indirectly via suppression of PTH secretion remains undecided.
Human Toll-Like Receptor 2 Mediates Monocyte Activation by Listeria monocytogenes, But Not by Group B Streptococci or Lipopolysaccharide1

Human Toll like receptor (TLR) 2 has been implicated as a signaling receptor for LPS from Gram-negative bacteria and cell wall components from Gram-positive organisms. In this study, we investigated whether TLR2 can signal cell activation by the heat-killed group B streptococci type III (GBS) and Listeria monocytogenes (HKLM). HKLM, but not GBS, showed a time- and dose-dependent activation of Chinese hamster ovary cells transfected with human TLR2, as measured by translocation of NF-κB and induction of IL-6 production. A mAb recognizing a TLR2-associated epitope (TL2.1) was generated that inhibited IL-6 production from Chinese hamster ovary-TLR2 cells stimulated with HKLM or LPS. The TL2.1 mAb reduced HKLM-induced TNF production from human monocytes by 60%, whereas a CD14 mAb (3C10) reduced the TNF production by 30%. However, coadministrating TL2.1 and 3C10 inhibited the TNF response by 80%. In contrast to this, anti-CD14 blocked LPS-induced TNF production from monocytes, whereas anti-TLR2 showed no inhibition. Neither TL2.1 nor 3C10 affected GBS-induced TNF production. These results show that TLR2 can function as a signaling receptor for HKLM, possibly together with CD14, but that TLR2 is unlikely to be involved in cell activation by GBS. Furthermore, although LPS can activate transfected cell lines through TLR2, this receptor does not seem to be the main transducer of LPS activation of human monocytes. Thus, our data demonstrate the ability of TLR2 to distinguish between different pathogens.
Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response*

Diabetic cardiac dysfunction is associated with decreased rates of myocardial glucose oxidation (GO) and increased fatty acid oxidation (FAO), a fuel shift that has been shown to sensitize the heart to ischemic insult and ventricular dysfunction. We sought to evaluate the metabolic and functional consequences of chronic suppression of GO in heart as modeled by transgenic mice with cardiac-specific overexpression of pyruvate dehydrogenase kinase 4 (myosin heavy chain (MHC)-PDK4 mice), an inhibitor of pyruvate dehydrogenase. Hearts of MHC-PDK4 mice were shown to exhibit an insulin-resistant substrate utilization profile, characterized by low GO rates and high FAO flux. Surprisingly, MHC-PDK4 mice were not sensitized to cardiac ischemia-reperfusion injury despite a fuel utilization pattern that phenocopied the diabetic heart. In addition, MHC-PDK4 mice were protected against high fat diet-induced myocyte lipid accumulation, likely related to increased capacity for FAO. The high rates of mitochondrial FAO in the MHC-PDK4 heart were related to heightened activity of the AMP-activated protein kinase, reduced levels of malonyl-CoA, and increased capacity for mitochondrial uncoupled respiration. The expression of the known AMP-activated protein kinase target, peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a master regulator of mitochondrial function and biogenesis, was also activated in the MHC-PDK4 heart. These results demonstrate that chronic activation of PDK4 triggers transcriptional and post-transcriptional mechanisms that re-program the heart for chronic high rates of FAO without the expected deleterious functional or metabolic consequences.
Solid Fuel from Oil Palm Biomass Residues and Municipal Solid Waste by Hydrothermal Treatment for Electrical Power Generation in Malaysia: A Review

Malaysia generated 156,665 gigawatt-hours (GWh) of electricity in 2016 of which the biggest share of 48.4% was sourced from coal and coke. Malaysia coal consumption was met by 90.5% of imported coal due to high demand from the power sector. Malaysia also has a vast biomass resource that is currently under-utilised for electricity generation. This paper reviews the potential of oil palm residues and municipal solid waste (MSW) for alternative coal replacement employing hydrothermal treatment (HTT). In 2017, about 51.19 million tonnes (Mt) of oil palm waste was available with 888.33 peta-joule (PJ) energy potential to generate 88.03 terawatt-hours (TWh) electricity from oil palm fronds (OPF) and oil palm trunks (OPT), empty fruit bunch (EFB), mesocarp fibre (MF), palm kernel shell (PKS) and palm oil mill effluent (POME). Meanwhile, the MSW energy potential and electricity generation potential was estimated at 86.50 PJ/year and 8.57 TWh/year, respectively. HTT with washing co-treatment eliminates the use of drying for converting range of biomass and MSW into clean solid fuel known as hydrochar. The hydrochar increased in caloric value with lower moisture, Potassium (K) and Chlorine (Cl) contents. These value-added fuels can be used as coal alternative and reduce dependency on imported coal for energy security in Malaysia.
Custom Financial Advice versus Simple Investment Portfolios: A Life Cycle Comparison

Using a theoretical life cycle model, we evaluate how much workers benefit from having the option to hire a financial advisor when it is costly for employees to rebalance their own financial portfolios. Results indicate that having access to a financial advisor at the start of one’s career can be quite beneficial. If delegation to an advisor is available only a decade after entering the labor market, the benefit of delegation is cut by half, and it falls further if delegation is available only later in life (at age 60). We also examine whether simpler target date funds (TDF) and fixed-weight portfolios benefit consumers, compared to the outcomes with customized financial advice. We show that the simpler portfolio products would need to be provided at zero cost, in order to benefit consumers as much as having access to a financial advisor.
Adaptive Video Streaming over CCN with Network Coding for Seamless Mobility

We consider the benefits brought by network coding in Information-Centric Networks (ICNs) in the case of a video streaming application. Network coding, when combined with ICN, allows a data transfer session to use multiple sources for the content seamlessly. It permits the client fetching the content to use multiple interfaces at the same time in an asynchronous manner, while using their capacity in an additive manner. This allows to create a logical link between the user and the content. In the case of video streaming, this logical link allows the rate adaptation logic to find the proper streaming rate while using multiple links concurrently. We implemented a video streaming system which works using network coding and CCN. We have shown that this implementation performs satisfactorily, and has comparable performance to a system without network coding in the unicast single source, single path case, and delivers significant performance gain (better QoE, higher throughput) when the video client retrieves the stream from multiple concurrent sources. We hope to demonstrate that network coding and CCN provides seamless mobility for a video streaming application.
A Energy efficient data-dissemination protocol with multiple virtual grid in wireless sensor network

Sensor networks are composed of a great number of sensor nodes. Since all sensor nodes are energy-restricted and hardly to recharge. So in order to prolong network life, it is very important to minimize energy consumption. However, the energy consumption may significantly increase if mobile sources or sinks exist in sensor networks. The reason is that the routing information for mobile sources and sinks needs to be update frequently for efferent data delivery. The routing algorithm supporting mobile sinks should consider not only continuous data delivery but also the energy consumption of sensor nodes. However, most of existing research e.g. [2, 3] focuses on even energy consumption while rarely considers the mobility of sinks and sources. In this paper, we propose an efficient routing protocol with multiple virtual grid to reduce energy consumption and improve packets delivery efficiency. Simulation results show that our algorithm can guarantee high data delivery ratio and low average delivery delay, while consumes lower energy then existing routing protocols in sensor networks.
A dynamic routing algorithm for multi-domain photonic networks using averaged link load information

We propose an inter-domain path routing algorithm for multi-domain photonic networks. The proposed algorithm introduces a step-wise weighting technique and utilizes averaged link load information of each domain and that of a link set between each adjacent domain pair. Numerical experiments demonstrate that the proposed algorithm outperforms a conventional method in terms of blocking probability and matches that achieved without domain segmentation.
Firm performance revisited: Idiosyncratic macroeconomic exposure and firm size. Evidence from the United States

A systematic approach is adopted to incorporate exogenous macroeconomic information into firm-level performance assessment based on firm fundamentals. A large sample of US-based firms over the 2009-2017 time period is used, with both domestic and foreign sales subject to regional-specific macroeconomic conditions, measured via real GDP growth rates. The construction of a new macroeconomic exposure measure improves firm performance analysis. The results show that the effect of idiosyncratic macroeconomic exposure in conjunction with firm size is more prevalent for small-sized firms to determine performance. Secondly, performance of domestic firms is negatively affected by macroeconomic exposure in contrast to exporting firms. Therefore, this study contributes to the theoretical and empirical literature on firm performance by analyzing the sensitivity of firms, contingent on size, to macroeconomic exposure changes.
Cooperation between Medicine and Sociology in Head and Neck Oncology

Twenty-first-century medicine is facing many challenges—knowledge and command of technical advances, research development, team management, knowledge transmission, and adaptation to economic constraints—without neglecting “human” aspects, via transformed carer-patient relationships, social change, and so on. The “modern” physicians know that simply treating disease is no longer enough. One of their essential missions lies in offering the individual patient overall care, which implies acknowledging the latter as an individual within a family, social, and professional environment. Indeed, medical practice requires pluridimensional knowledge of the patients’ experience of their disease. Yet the contribution sociology can offer to health care remains largely unknown to many physicians, and medical training includes only limited instruction in the human sciences. On the basis of a few observations taken from sociological research, we would like to demonstrate how, in head and neck oncology, interdisciplinary collaboration between medicine and sociology can prove propitious to improving patient care and attention to their close relations.
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias.

BACKGROUND The BCR-ABL tyrosine kinase inhibitor imatinib is effective in Philadelphia chromosome-positive (Ph-positive) leukemias, but relapse occurs, mainly as a result of the outgrowth of leukemic subclones with imatinib-resistant BCR-ABL mutations. We evaluated dasatinib, a BCR-ABL inhibitor that targets most imatinib-resistant BCR-ABL mutations, in patients with chronic myelogenous leukemia (CML) or Ph-positive acute lymphoblastic leukemia (ALL). METHODS Patients with various phases of CML or with Ph-positive ALL who could not tolerate or were resistant to imatinib were enrolled in a phase 1 dose-escalation study. Dasatinib (15 to 240 mg per day) was administered orally in four-week treatment cycles, once or twice daily. RESULTS A complete hematologic response was achieved in 37 of 40 patients with chronic-phase CML, and major hematologic responses were seen in 31 of 44 patients with accelerated-phase CML, CML with blast crisis, or Ph-positive ALL. In these two phases, the rates of major cytogenetic response were 45 percent and 25 percent, respectively. Responses were maintained in 95 percent of patients with chronic-phase disease and in 82 percent of patients with accelerated-phase disease, with a median follow-up more than 12 months and 5 months, respectively. Nearly all patients with lymphoid blast crisis and Ph-positive ALL had a relapse within six months. Responses occurred among all BCR-ABL genotypes, with the exception of the T315I mutation, which confers resistance to both dasatinib and imatinib in vitro. Myelosuppression was common but not dose-limiting. CONCLUSIONS Dasatinib induces hematologic and cytogenetic responses in patients with CML or Ph-positive ALL who cannot tolerate or are resistant to imatinib. (ClinicalTrials.gov number, NCT00064233 [ClinicalTrials.gov].).
Predictors of intensive care unit transfer or death in emergency department patients with suspected infection

Objectives The aim of this study was to identify predictors of ICU transfer or death within 48 h obtainable within 4 h of admission in emergency department (ED) patients with suspected infection. Patients and methods This was a nested case–control study based on a prospective cohort of adult patients admitted to the ED at Aarhus University Hospital, in 2011, who had a blood culture drawn upon admission. Cases met the composite endpoint of ICU transfer or death within 4–48 h of admission. We identified up to three controls for each case, matched by age and admission month. We collected data on possible predictors from medical records. Univariate and multivariate logistic regressions were performed to identify predictors. Results A total of 1578 patients had a blood culture drawn in the ED. Among these, 61 (4%) patients were transferred to an ICU and 15 (1%) patients died within 4–48 h of admission. We could obtain complete data on 59 cases, which were matched to 165 controls. Significant predictors of ICU transfer or death within 4–48 h included temperature as a continuous variable, and neurologic (altered mental status), respiratory, and cardiovascular dysfunction. Conclusion Readily available clinical and laboratory variables at arrival in the ED can support identification of late deterioration leading to ICU transfer or death within 48 h of admission.
Hydrazidase, a Novel Amidase Signature Enzyme That Hydrolyzes Acylhydrazides

ABSTRACT The degradation mechanisms of natural and artificial hydrazides have been elucidated. Here we screened and isolated bacteria that utilize the acylhydrazide 4-hydroxybenzoic acid 1-phenylethylidene hydrazide (HBPH) from soils. Physiological and phylogenetic studies identified one bacterium as Microbacterium sp. strain HM58-2, from which we purified intracellular hydrazidase, cloned its gene, and prepared recombinant hydrazidase using an Escherichia coli expression system. The Microbacterium sp. HM58-2 hydrazidase is a 631-amino-acid monomer that was 31% identical to indoleacetamide hydrolase isolated from Bradyrhizobium japonicum. Phylogenetic studies indicated that the Microbacterium sp. HM58-2 hydrazidase constitutes a novel hydrazidase group among amidase signature proteins that are distributed within proteobacteria, actinobacteria, and firmicutes. The hydrazidase stoichiometrically hydrolyzed the acylhydrazide residue of HBPH to the corresponding acid and hydrazine derivative. Steady-state kinetics showed that the enzyme hydrolyzes structurally related 4-hydrozybenzamide to hydroxybenzoic acid at a lower rate than HBPH, indicating that the hydrazidase prefers hydrazide to amide. The hydrazidase contains the catalytic Ser-Ser-Lys motif that is conserved among members of the amidase signature family; it shares a catalytic mechanism with amidases, according to mutagenesis findings, and another hydrazidase-specific mechanism must exist that compensates for the absence of the catalytic Ser residue. The finding that an environmental bacterium produces hydrazidase implies the existence of a novel bacterial mechanism of hydrazide degradation that impacts its ecological role.