Miracle-dz/UniFAR-FTUs huggingface dataset:
Brand management – standing out from the crowd

This paper aims to provide a comprehensive understanding of how brand management research has evolved to inform future hospitality research agendas that are both theoretically and practically innovative and relevant. ,A review of leading tourism and hospitality journals, augmented by a review of leading mainstream marketing and services journals, over the past 20 years was undertaken. Focusing on papers with an emphasis on the brand, as reflected in the title, over 263 articles were reviewed. ,In contrast to the more established mainstream literature, brand management research in the hospitality literature is limited in both its depth and breadth. In seeking to go beyond mere replication, and in consideration of industry needs, the review informs the articulation of an integrative research framework that reflects the extant literature and illuminates new research pathways that, in anticipation of making a significant contribution to brand management theory, will enhance hospitality academic and practitioner understanding of brand management. ,The comprehensive critical review affords insight into areas of brand management research innovation, both from a topic and methods perspective. The proposed research agenda not only reflects industry priorities but also responds to gaps within academia’s current understanding of brand management theory, particularly within a service context. Grounded in classical theories and industry insight, the pursuit of topics advanced in the research agenda are expected to make a significant contribution to the theoretical understanding of the brand management concept in an applied setting, in addition to providing timely and relevant insight to practitioners seeking to stand out from the crowd. ,With brands dominating the hospitality landscape, insight derived from thought leading and innovative research is needed. With no comprehensive review of brand management research within the tourism and hospitality literature, clarity with respect to what is known and, more importantly, what is not known is not apparent. This paper addresses this paucity and, in doing so, gives hospitality academics a clear pathway to conducting meaningful and relevant brand management research from both theoretical and practical perspectives.
The Origins of the Ukraine Crisis and the Need for Collective Security between Russia and the West

The relationship between major powers in the world determines the level of global stability. Two constellations are imaginable: balance of power and collective security. The end of major (world or cold) wars offers possibilities for change from one constellation to another. This article tries to explain the origins of the Ukraine crisis. It posits that the crisis in Ukraine is only a symptom of a wider conflict between two major powers (or power blocs), whose origins can only be understood by assessing the post-Cold War security architecture in Europe. Instead of having integrated Russia in a collective security organization on an equal level, the West kept NATO alive and by doing so deteriorated the relationship with Russia. Despite different warnings from Moscow, NATO invited Ukraine to become member, and the EU offered Trade and Association Agreement talks to Ukraine. As a result, the relationship glided back towards a classic balance of power relation with spheres of influences. To prevent similar conflicts in the future, Russia should be integrated into the Euro-Atlantic security architecture. Ideally, the existing collective defence organization (NATO) should be transformed into a collective security organization with the inclusion of both Russia and Ukraine.
Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects.

OBJECTIVE To evaluate the rate of brain atrophy calculated from serial magnetic resonance imaging (MRI) registration as a surrogate marker of disease progression for use in clinical trials in Alzheimer disease (AD). METHODS Eighteen patients with mild to moderate AD and 18 age-matched normal controls underwent 2 MRI brain scans separated by a 12-month interval. Each individual's later scan was registered to their first scan, and the volume of cerebral tissue loss calculated directly from the registered and subtracted MRI scan pairs. The mean and SD of the rate of brain volume changes were used to estimate the sample sizes that would be needed in a clinical trial with a drug anticipated to modify disease progression by varying degrees. Comparable sample size estimates were performed with data for other methods of monitoring rates of brain atrophy, extracted from published papers. RESULTS The mean (SD) rate of brain atrophy for the patients with AD was 2.37% (1.11%) per year, while in the control group it was 0.41% (0.47%) per year. Based on these figures, to have 90% power to detect a drug effect equivalent to a 20% reduction in the rate of atrophy, 207 patients would be needed in each treatment arm. This assumes a 1-year placebo-controlled trial with a 10% patient dropout rate, and that 10% of scan pairs are unusable. CONCLUSION Registration of serial MRI volume images provides a powerful method of quantification of brain atrophy that can be used to monitor progression of AD in clinical trials.
Detection of hepatic oxidative DNA damage in patients with hepatoblastoma and children with non-neoplastic disease.

BACKGROUND The authors have revealed a significant association between hepatoblastoma and low birth weight. This study was done to explore the evidence that liver cells were oxidatively damaged, based on the hypothesis that oxidative damage to DNA is involved in the development of hepatoblastoma in children of low birth weight. PROCEDURE Oxidative DNA damage in the liver was examined by immunohistochemically detecting the presence of a DNA repair product, 8-hydroxy-2'-deoxyguanosine (8-OHdG), in five patients with hepatoblastoma and 14 children with non-neoplastic disease. RESULTS Positive staining for 8-OHdG was observed in all five patients with hepatoblastoma. Distribution of 8-OHdG positivity was diffuse in the intralobular area in one patient and was restricted to the periportal area of the lobules in four patients. There was no apparent correlation between birth weight of the patients, histological findings in the liver, and the distribution of 8-OHdG positivity. In children with non-neoplastic disease, 8-OHdG was detected in nine of 14 patients, and 8-OHdG was positive in the intralobular area of the liver parenchyma except in one patient. CONCLUSIONS These results suggest that the cause of oxidative DNA damage in patients with hepatoblastoma may be different from the cause, extensive parenchymal damage to the liver, in children with non-neoplastic disease, but the 8-OHdG formation is not specific to hepatoblastoma patients of low birth weight. Further studies to elucidate the true reason for the high incidence of hepatoblastoma in children of low birth weight are necessary.
Hyperthermic regional perfusion with melphalan and a combination of melphalan and actinomycin D in the treatment of locally metastasized malignant melanomas of the extremities

From September 1969 through 1979, 68 patients with already locally metastasized malignant melanomas of the extremities were treated by hyperthermic regional perfusion and local excision(s). Of these, 53 patients could be evaluated after a follow‐up of at least 2 years: 31 had been perfused with melphalan and 22 with melphalan in combination with actinomycin D. Local recurrence rates were about the same in both groups: 32 versus 33%. The same applied to the symptom‐free interval between perfusion and local recurrence: about 12 versus about 13 months. Virtually all recurrences in both groups (90 versus 85%) were seen within 2 years. The interval between perfusion and systemic metastization was also roughly the same: about 25 versus about 23 months. These results indicate the need for better chemotherapeutics in order to achieve further improvement. The results of these perfusions were otherwise by no means disappointing, and hyperthermic regional perfusion is indicated in the treatment of patients with locally metastasized malignant melanomas.
Localization of multiple insulators by orientation angle detection and binary shape prior knowledge

Failure of insulators leads to failure of transmission system and causes heavy loss to the power sector. This has necessitated helicopter inspection on transmission line. Therefore, localizing insulators in collected aerial image is an essential step for automatic fault detection. This paper proposes a localization method of multiple insulators with different angles in complex aerial image based on Orientation Angle Detection and Binary Shape Prior Knowledge (OAD-BSPK). Detect possible orientation angles of insulators preliminarily. For each possible angle, reserve insulator by its binary shape prior knowledge. Traverse all the possible angles, and multiple insulators can be localized in aerial image finally. This paper uses a large number of real aerial captured images as experimental images. The results show that this method can localize multiple insulators with different orientation angles in complex aerial image, and has higher positioning precision, lower computational complexity and lower time consuming compared with existing methods. This method can meet the requirements of insulators' real-time and accurate localization.
Evolution of Hemispheric Specialization: Advantages and Disadvantages

Lateralization of the brain appeared early in evolution and many of its features appear to have been retained, possibly even in humans. We now have a considerable amount of information on the different forms of lateralization in a number of species, and the commonalities of these are discussed, but there has been relatively little investigation of the advantages of being lateralized. This article reports new findings on the differences between lateralized and nonlateralized chicks. The lateralized chicks were exposed to light for 24 h on day 19 of incubation, a treatment known to lead to lateralization of a number of visually guided responses, and the nonlateralized chicks were incubated in the dark. When they were feeding, the lateralized chicks were found to detect a stimulus resembling a raptor with shorter latency than nonlateralized chicks. This difference was not a nonspecific effect caused by the light-exposed chicks being more distressed by the stimulus. Instead, it appears to be a genuine advantage conferred by having a lateralized brain. It is suggested that having a lateralized brain allows dual attention to the tasks of feeding (right eye and left hemisphere) and vigilance for predators (left eye and right hemisphere). Nonlateralized chicks appear to perform these dual tasks less efficiently than lateralized ones. Reference is made to other species in discussing these results.
In vivo pH and metabolite changes during a single contraction in rat uterine smooth muscle

1 We have used 31P NMR spectroscopy to measure metabolites and pHi at three periods during a phasic contraction of the uterus, in vivo, to determine whether they change as a consequence of contraction. The regular uterine contractions were recorded via a balloon catheter in the uterine lumen. Each phasic contraction was divided into three parts: the period between contractions (rest), the development of force (up) and the relaxation of force (down). The NMR data were summed separately from each of these three periods over 20‐40 successive contractions. 2 Significant changes in ATP, phosphocreatine (PCr) and inorganic phosphate (Pi) occurred during the contraction. [ATP] fell from 2.0 to 1.6 mM and [PCr] from 2.6 to 2.0 mM during the up period, while [Pi] increased from 2.2 to 2.8 mM. Recovery of ATP and PCr occurred during the relaxation part of the contraction, whereas Pi did not fully recover until the contraction was complete. 3 Significant acidification from pH 7.28 ± 0.02 at rest to 7.16 ± 0.02, occurred with contraction. This acidification is greater than that previously reported for in vitro uterine preparations. Measurements of uterine blood flow show that it decreased with contraction. Therefore, ischaemia, in addition to the metabolic consequences of contraction, may account for the larger acidification observed in vivo. 4 Lowering pHi in an in vitro uterine preparation by a similar level to that found in vivo produced a significant reduction of the phasic contractions. Thus we propose that these changes, especially the fall in pHi during force development, feed back negatively on the contraction to limit its strength, and may help prevent uterine ischaemia and fetal hypoxia during labour.
Pharmakologie in der Ernährungstherapie: Untersuchung zum Stellenwert pharmakologischer Kenntnisse und Vorschlag eines Stoffkatalogs

Zusammenfassung Hintergrund Um ein optimales Therapieergebnis zu erzielen, müssen Arzneimittel- und Ernährungstherapie bestmöglich verknüpft werden – und zwar sowohl im ambulanten als auch im stationären Bereich. Fraglich ist, wie Ernährungsfachkräfte die pharmakologischen Inhalte in Ausbildung und Studium vor ihrem berufspraktischen Hintergrund einschätzen. Ebenfalls unklar ist, wie ein spezifisch ernährungstherapeutischer Stoffkatalog „Pharmakologie in der Ernährungstherapie“ konzipiert sein sollte. Material und Methoden Um die Einschätzung des Stellenwerts pharmakologischer Kenntnisse durch Ernährungsfachkräfte zu evaluieren, wurde eine deutschlandweite Online-Umfrage durchgeführt. Anschließend wurde durch systematische Analyse ein Stoffkatalog zur Integration in die Curricula der Ernährungsfachkräfte konzipiert. Ergebnisse An der Umfrage nahmen 101 Teilnehmer teil, von denen 65 % Diätassistenten/-innen und 35 % anderweitig beruflich qualifiziert waren. 98,9 % der Teilnehmer gaben an, im Rahmen ihrer Ernährungsberatung eine Arzneimittelanamnese zu erheben. 98 % der Teilnehmer schätzten, dass mehr pharmakologische Kenntnisse für die tägliche Arbeit hilfreich wären; 99 % hielten die wechselseitigen Einflüsse von Ernährungs- und Arzneimitteltherapie für relevant. Lediglich 10 % der Teilnehmer sahen ihre pharmakologischen Kenntnisse als „vollkommen ausreichend“ an. Die Analyse der Schnittmengen zwischen Ernährungsmedizin, Ernährungswissenschaft, Diätetik und Pharmakologie führte zur Identifizierung ernährungstherapeutisch relevanter pharmakologischer Themenfelder; diese wurden in einem Stoffkatalog konkretisiert. Schlussfolgerung Spezifische pharmakologische Aspekte sind in der Ernährungstherapie relevant, werden bisher in Ausbildung und Studium von Ernährungsfachkräften jedoch nicht adäquat abgebildet. Der vorgeschlagene Stoffkatalog „Pharmakologie in der Ernährungstherapie“ umfasst die ernährungstherapeutisch relevanten pharmakologischen Themenfelder und kann als Vorlage zur curricularen Erweiterung der Ausbildungs- bzw. Studiengänge dienen.
An on-board inverter controlled by the waveform switching technique

This work discusses operating principles and performance of a 400Hz sine-wave inverter intended for aerospace applications. Its operation is controlled in pulse-width modulation (PWM) on the basis of the "waveform switching" technique. According to this fully-digital design approach, digitised sinewaves are stored in a solid-state memory; a control circuit cyclically reads the waveform samples and correspondingly sets duty cycle for every transistor in output bridge. Amplitude control is provided by changing the digitised waveform to be reproduced in output, by means of a specific feedback circuit and of a memory with several sample sets stored, corresponding to sinewaves with different amplitude. Design of a prototype and its operation with reference to typical specifications for on-board power distribution systems are discussed
The Person and Diabetes in Psychosocial Context

This review spans life with diabetes from the first year through the succeeding period of relatively good health, into the phase when the patient needs to accommodate for more symptoms and impaired functioning. Focusing on autonomy, vulnerability to fears, and vocational choices, this article compares effects of diabetes on children and youths with effects on those with onset in later life. A concept of biopsychosocial homeostasis helps to explain: (1) why patients turn to a physician when they do; (2) how the physician may often save the patient time and money by helping that patient to change psychological and social components of well-being and functioning—and highlights the importance of these; (3) how to treat depressive disorder; (4) how to discuss worst fears and encourage patients to play with their unpleasant imaginings; and (5) how to reduce hypoglycemia. Repeated hypoglycemic episodes have the cumulative deleterious effect of undercutting the patient's and others' sense that the patient is dependable, with impaired performance and even serious occupational and marital repercussions. Educational tactics are suggested for the patient with IDDM who finds it harder to identify early levels of hypoglycemia; that patient must learn to respond to specific clues of mild hypoglycemia, stemming from defective thinking and emotional and sexual functioning. There is no substitute for a full history and an empathic understanding of the patient's imaginings, relationships, and circumstances.
Distributed Finite-Time Voltage and Frequency Restoration in Islanded AC Microgrids

This paper investigates the distributed finite-time restoration of inverter voltage and frequency terms in an islanded ac microgrid. Formulating networked inverters of ac microgrids as a cooperative multiagent system, the voltage and frequency restoration can be cast as synchronization problems, while the active power sharing can be viewed as a consensus problem. One popular distributed control approach is the neighbor-based linear consensus protocol, where the consensus at the frequency and voltage set points is achieved over an infinite-time horizon with an exponential convergence. To achieve accelerated convergence and better disturbance rejection properties, a distributed finite-time control protocol, based on feedback linearization approach, is proposed for voltage restoration, which synchronizes the voltage term at each inverter to the reference value in finite time period. Then, a finite-time control protocol for both frequency restoration and active power sharing problems is proposed to synchronize the microgrid frequency to the nominal value, and share the active power among inverters based on their ratings in a finite time. Rigorous Lyapunov proofs are provided to establish the upper bounds on the convergence times. Numerical simulation studies verify the effectiveness of the proposed control protocols.
A synthesis of qualitative research exploring the barriers to staying in work with chronic musculoskeletal pain

Abstract Purpose: Qualitative research can help to advance our understanding, management and prevention of work disability. Our aim was to integrate qualitative research findings in order to increase our understanding of barriers to stay in work with chronic pain. Methods: We searched five electronic bibliographic databases until September 2012, supplemented by citation tracking and hand-searching. We used meta-ethnography to synthesis our findings. Central to meta-ethnography is identifying “concepts” and developing a conceptual model. Concepts were compared and organised into categories. Results: The following categories can have an impact on the decision to remain in work: struggling to affirm myself as a good worker; balancing life and work in the face of unpredictable symptoms; my work colleagues don't believe me; the system does not facilitate return to work; the battle for legitimacy. Conclusions: Our innovation is to present an internationally relevant model based on a conceptual synthesis. This model highlights the adversarial work experience of people with chronic. The papers span 15 years of qualitative research. A significant finding is that these themes continue to pervade the current work environment for those in pain, and this has clear implications for education, social care and policy. Implications for Rehabilitation People with chronic pain face an adversarial struggle to maintain their credibility at work. Strategies to maintain personal credibility can have an adverse effect on working lives. Changes at a systems level are needed to facilitate continuance and return to work. Cultural changes in the way that we view people with pain would help to keep people in work.
[Treatment of humeral shaft fracture with intramedullary procedures (Seidel nail, Marchetti-Vicenzi nail, Prevot pins)].

Humeral shaft fractures can be treated either conservatively or operatively. Plating of the humerus is the established operative method, but recently interest has also been focussed on intramedullary nailing. Fifty-nine cases of humeral fractures treated with intramedullary nailing (Seidel/Marchetti-Vicenzi/Prévot) from January 1991 to December 1995 (44 fractures after trauma, 11 pathological fractures, 3 pseudarthroses, 1 re-fracture). Closed reduction in 55/59 cases. One infection (soft tissue); 2/48 pseudarthrosis (indication for nailing: pseudarthrosis! ). No iatrogenic palsy of the radial nerve. Functional postoperative treatment in all 44 cases of humeral fractures after adequate trauma. One poor functional result: periarticular ossification after retrograde nailing, possibly connected with long-term respiratory treatment after trauma. Treatment of humeral shaft fractures by intramedullary nailing is favoured in our clinic (low complication rates, excellent or good functional results, limited approaches, small scars). Proximal fractures should be treated by the Seidel nail (stable interlocking of the proximal fragment); very distal fractures need Prévot nailing (reaming of condylar canals). All other fractures of the humeral shaft can be treated by each of the implants used in our clinic. Pathological fractures are an excellent indication for intramedullary stabilization. These patients benefit from stable fixation without intense surgical trauma. Pseudarthrosis, according to our limited experience, seems to require plating plus bone grafting. Plating is also recommended if revision of the radial nerve becomes necessary.
SimpleCore: A connectionless, best effort, no-mobility-supporting 5G core architecture

This paper proposes a highly simplistic 5G core network design. Instead of providing mobility support and Quality-of-Service for all traffic as in the 4G core network EPC, the default service of 5G should be connectionless, best effort and without support for node mobility. This is based on the observation that applications like video streaming or web surfing that create the bulk of the traffic in mobile networks can handle node mobility at the application layer and traverse the best effort Internet anyway. This paper provides the architecture for such a simplified 5G core network, demonstrates the feasibility of our proposal through experiments on an Android smartphone and outlines the many open research challenges of this fundamentally different approach to mobile networking.
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

Mitochondrial fission requires recruitment of the GTPase Drp1 to mitochondria, but the molecules that mediate this recruitment have been disputed. Fis1, Mff, MiD49, and MiD51 can all recruit Drp1 to mitochondria and promote fission. MiD49 and MiD51 can promote mitochondrial fission, but their activity depends on cellular context.