Miracle-dz/UniFAR-FTUs huggingface dataset:
Pattern of motor and cognitive deficits in detoxified alcoholic men.

BACKGROUND Chronic excessive consumption of alcohol produces marked deficits in cognitive and motor abilities, although not all functions are affected to the same extent. Furthermore, although the occurrence of neuropsychological deficits in recently detoxified alcoholics is firmly established, the relative severity of these deficits, the specific neural systems that underlie the deficits, and their relationship to age and alcohol consumption variables either are less established or have proven elusive altogether. METHODS We administered an extensive battery of neuropsychological tests, chosen for their known sensitivity to brain lesions in specific locations, to 71 recently (1 month) detoxified alcoholic men and 74 healthy controls who spanned the adult age range. Test scores were standardized to the controls for age and grouped a priori into composites that reflected performance in six functional domains: executive functions, short-term memory, upper limb motor ability, declarative memory, visuospatial abilities, and gait and balance. Analogous verbal and nonverbal materials and left- and right-hand upper limb motor tasks were used to test whether alcohol-related deficits were greater for left or right hemisphere. RESULTS Compared with controls, the alcoholics were impaired on executive functions, visuospatial abilities, and gait and balance even after we accounted for group differences in estimated premorbid IQ and education. Within the alcoholic group, the most salient deficits were in gait and balance and visuospatial abilities. No consistent lateralized deficit was observed across the four domains tested. Unlike the cognitive composites, the upper limb motor ability and gait and balance composites both showed increasing vulnerability to age, with an independent contribution to the gait and balance dysfunction from the amount of alcohol consumed over a lifetime. CONCLUSIONS The pattern of functional deficits implicates at least two principal neural systems: the cerebellar-frontal system and the corticocortical system between the prefrontal and parietal cortices. In addition, age and amount of alcohol consumption were better predictors of motor than cognitive impairments.
Anaerobic Elemental Sulfur Reduction by Fungus Fusarium oxysporum

Reduction of inorganic sulfur compounds by the fungus Fusarium oxysporum was examined. When transferred from a normoxic to an anoxic environment, F. oxysporum reduced elemental sulfur to hydrogen sulfide (H2S). This reaction accompanied fungal growth and oxidation of the carbon source (ethanol) to acetate. Over 2-fold more of H2S than of acetate was produced, which is the theoretical correlation for the oxidation of ethanol to acetate. NADH-dependent sulfur reductase (SR) activity was detected in cell-free extracts of the H2S-producing fungus, and was found to be up-regulated under the anaerobic conditions. On the other hands both O2 consumption by the cells and cytochrome c oxidase activity by the crude mitochondrial fractions decreased. These results indicate that H2S production involving SR was due to a novel dissimilation mechanism of F. oxysporum, and that the fungus adapts to anaerobic conditions by replacing the energy-producing mechanism of O2 respiration with sulfur reduction.
Risk assessment of power system with high penetration of wind power considering negative peak shaving and extreme weather conditions

The variation of wind power affects the operation of coal-wind intensive system. With the negative peak character, the variation of wind power daily output is in contrast to that of the load in power system. Even worse case is the common-mode tripping of wind turbines closing to cut-off wind speed while a wind farm experience extreme wind speeds caused by a severe weather situation. Based on actual operation data of Gansu Grid, China, in 2013, the probability characters of negative peak shaving and ramp rate are obtained. Then some risk indices are defined for risk assessment and the UC model is applied to probe the increment of reserve demand. A simulation based on Gansu Grid is given at last. The results show that the reserve demand increases with the wind power integration and the operation risk has a typical distribution of exponential function contains two types of risk events: HILF (High Impact and Low Frequency) and LIHF (Low Impact and High Frequency).
Hepatoprotective Effect of Angelica archangelica in Chronically Ethanol-Treated Mice

Angelica archangelica (AAA) has been effectively used in folk medicines as a remedy against stomachal and intestinal disturbances, arthritic disease, etc. However, there is still lack of scientific proof about its antioxidant capability. This study aimed at investigating the effects of total AAA against chronic ethanol-induced hepatotoxicity. ICR mice were divided into five groups, each consisting of 10 animals. A single dose of ethanol (70%, 0.1 ml, p.o.) was used to induce hepatotoxicity in these mice which resulted in a significant elevation of the activities of serum GOT and GPT. Treatment of mice with AAA (10, 25, and 50 mg/kg p.o.) after 2 weeks ameliorated the ethanol-induced hepatotoxicity effects. Hepatotoxicity was evidenced by a significant increase in hepatic lipid peroxidation manifested as the presence of malondialdehyde. It was found that AAA inhibits the malondialdehyde formation in mouse liver homogenates both in vitro and in vivo. AAA is cytoprotective agent effective against chronic ethanol-induced hepatotoxicity, possibly through inhibition of the production of oxygen free radicals that cause lipid peroxidation, and hence indirectly protects the liver from oxidative stress.
Rescue and serotypic characterization of noncultivable human rotavirus by gene reassortment

Thirty-three of 50 noncultivable human rotavirus strains from a variety of locations were successfully rescued by gene reassortment. The serotype of each of the 33 strains was investigated by a qualitative cytopathic effect neutralization assay. Nineteen strains resembled the previously characterized human rotavirus serotype Wa, whereas three strains were serologically related to the DS-1 strain. Eleven strains appeared to be serotypically distinct from the Wa and DS-1 strains and thus apparently represent one or more new human rotavirus serotypes.
Treatment of Asthma by Nicotinic Acid

measured to a free diet has often been made without deterioration in health or vigour. 2. It may be argued that the patients believed to be eating an uncontrolled diet were in fact unconsciously eating a diet which maintained a fairly accurate carbohydrate balance. This is not so. 3. It may be argued that the insulin requirements of my patients are greater than they would be on a measured diet. This may be so, but, as none of my patients need more than 60 units a day and the majority take between 10 and 40, the point is not very important. (This point would be important if it could be shown that cases of established diabetes under control gradually progressed towards complete cure. This question has already been dealt with in the paragraph on acute diabetes.) 4. It may be argued that in 20 years' time the fate of the surviving uncontrolled diabetics may be worse in respect of late complications than that of the controlled group. That is certainly possible. It is no answer for me to claim (as I do) that over 10 years' observation reveals no evidence of premature arteriosclerosis, for it may be that in the development of late diabetic complications there is a clinically silent stage analogous to that in the development of syphilitic aortitis. If it were not for this objection I would have no hesitation in proclaiming that the maintenance of a carbohydrate balance was an unnecessary adjunct to the treatment of diabetes. But time will settle the question. Twenty years have already elapsed since the isolation of insulin, and soon many young diabetics treated in the first decade after its introduction to therapeutics will be reaching middle age. It will then be possible to judge between the rebellious and the docile, and for that very reason I wish to repeat my plea for a continued careful observation of the former class.
Solution Structure of an Insect Growth Factor, Growth-blocking Peptide*

Growth-blocking peptide (GBP) is an insect growth factor consisting of 25 amino acid residues that retards the development of lepidopteran larvae at high concentration while it stimulates larval growth at low concentration. In this study, we determined the solution structure of GBP by two-dimensional1H NMR spectroscopy. The structure contains a short segment of double-stranded β-sheet involving residues 11–13 and 19–21 and a type-II β-turn in the loop region (residues 8–11), whereas the N and C termini are disordered. This is the first report of the three-dimensional structure of the peptiderigic insect growth factor, and the structure of the well defined region of GBP was found to share similarity with that of the C-terminal domain of the epidermal growth factor (EGF). Because GBP has been reported to stimulate DNA synthesis of not only insect cells but also human keratinocyte cells at the same level with EGF, the structural similarity between GBP and EGF may lead to the interaction of GBP to EGF receptor.
Long-term outcome of bilateral lung volume reduction in 250 consecutive patients with emphysema.

OBJECTIVE Numerous reports have confirmed the early benefits of lung volume reduction surgery for selected patients with emphysema. This report documents the long-term survival and functional results after lung volume reduction surgery. METHODS Between January 1993 and June 2000, a total of 250 consecutive patients underwent bilateral lung volume reduction surgery through median sternotomy at our institution. All patients had disabling dyspnea, thoracic hyperinflation, and a heterogeneous pattern of emphysema with suitable target areas for resection. Preoperative pulmonary rehabilitation was required and post-rehabilitation data were used as the baseline for data analysis. Follow-up ranged from 1.8 to 9.1 years (median 4.4 years). RESULTS Prolonged air leaks (>7 days) were the most common complication (45.2%, n = 113). Reexploration rates for air leak and bleeding were 3.2% (n = 8) and 1.2% (n = 3), respectively. Eighteen patients (7.2%) required reintubation and mechanical ventilation. The in-hospital mortality in this series was 4.8% (n = 12). The median length of hospitalization was 9 days (range 4-168 days). Kaplan-Meier survivals after lung volume reduction surgery were 93.6%, 84.4%, and 67.7% at 1, 3, and 5 years, respectively. Eighteen patients (7.2%) have subsequently undergone lung transplantation after a median interval of 4.3 years (range 2.1-6.4 years). Spirometric values, lung volumes, and gas exchange parameters improved after surgery. The forced expiratory volume in 1 second and the residual volume showed statistically significant improvements between preoperative values and each time point of follow-up. Health-related quality of life showed significant postoperative improvement and with time correlated well with the improvement in forced expiratory volume in 1 second. CONCLUSIONS Lung volume reduction surgery produces significant functional improvement for selected patients with emphysema. For most of these patients, benefits appear to last at least 5 years.
AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

Abnormal tau phosphorylation resulting in detachment of tau from microtubules and aggregation are critical events in neuronal dysfunction, degeneration, and neurofibrillary pathology seen in Alzheimer's disease. Glycogen synthase kinase‐3β (GSK3β) is a key target for drug discovery in the treatment of Alzheimer's disease and related tauopathies because of its potential to abnormally phosphorylate proteins and contribute to synaptic degeneration. We report the discovery of AZD1080, a potent and selective GSK3 inhibitor that demonstrates peripheral target engagement in Phase 1 clinical studies. AZD1080 inhibits tau phosphorylation in cells expressing human tau and in intact rat brain. Interestingly, subchronic but not acute administration with AZD1080 reverses MK‐801‐induced deficits, measured by long‐term potentiation in hippocampal slices and in a cognitive test in mice, suggesting that reversal of synaptic plasticity deficits in dysfunctional systems requires longer term modifications of proteins downstream of GSK3β signaling. The inhibitory pattern on tau phosphorylation reveals a prolonged pharmacodynamic effect predicting less frequent dosing in humans. Consistent with the preclinical data, in multiple ascending dose studies in healthy volunteers, a prolonged suppression of glycogen synthase activity was observed in blood mononuclear cells providing evidence of peripheral target engagement with a selective GSK3 inhibitor in humans.
Resistance switching of Al doped ZnO for Non Volatile Memory applications

Introduction Since the first observation of the bi-stable resistance states in 1960s, a great amount of work has been done in an effort to understand the switching mechanism and to improve electrical properties for Resistance Random Access Memory (RRAM) applications. Consequently, numerous oxides materials such as Nb2O5 , TiO2 , NiO[1] , Al2O3 and ferroelectrics oxide have been reported for RRAM applications. However, high operating voltage and current, poor endurance, and low electrical uniformity made the resistance memory unfavorable. Recently, perovskite structure materials such as Pr1-xCaxMnO3 (PCMO)[2] and epitaxial Cr-doped SrTi(Zr)O3 [3-4] films have also shown welldeveloped resistance switching either by DC or AC modes. Considering perovskite oxides with more than three components system, it is difficult to apply these materials for conventional semiconductor manufacturing processes. In this point of view, binary oxides with good resistive switching behavior have advantages. In this paper, we have investigated the resistance switching characteristics of nonstoichiometric oxides such as ZrOx , STOx and Al doped ZnO (Al:ZnO) on the silicon for nonvolatile memory applications.
T₃-induced liver AMP-activated protein kinase signaling: redox dependency and upregulation of downstream targets.

AIM To investigate the redox dependency and promotion of downstream targets in thyroid hormone (T3)-induced AMP-activated protein kinase (AMPK) signaling as cellular energy sensor to limit metabolic stresses in the liver. METHODS Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle (NaOH 0.1 N; controls) and studied at 8 or 24 h after treatment. Separate groups of animals received 500 mg N-acetylcysteine (NAC)/kg or saline ip 30 min prior T3. Measurements included plasma and liver 8-isoprostane and serum β-hydroxybutyrate levels (ELISA), hepatic levels of mRNAs (qPCR), proteins (Western blot), and phosphorylated AMPK (ELISA). RESULTS T3 upregulates AMPK signaling, including the upstream kinases Ca(2+)-calmodulin-dependent protein kinase kinase-β and transforming growth factor-β-activated kinase-1, with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC. Accordingly, AMPK targets acetyl-CoA carboxylase and cyclic AMP response element binding protein are phosphorylated, with the concomitant carnitine palmitoyltransferase-1α (CPT-1α) activation and higher expression of peroxisome proliferator-activated receptor-γ co-activator-1α and that of the fatty acid oxidation (FAO)-related enzymes CPT-1α, acyl-CoA oxidase 1, and acyl-CoA thioesterase 2. Under these conditions, T3 induced a significant increase in the serum levels of β-hydroxybutyrate, a surrogate marker for hepatic FAO. CONCLUSION T3 administration activates liver AMPK signaling in a redox-dependent manner, leading to FAO enhancement as evidenced by the consequent ketogenic response, which may constitute a key molecular mechanism regulating energy dynamics to support T3 preconditioning against ischemia-reperfusion injury.
Importance de la semantique dans le codage CNF de contraintes de cardinalite : application au diagnostic de SED

Le codage d'un probleme a un impact enorme surle temps de calcul en SAT : un solveur SAT peut re-soudre tres facilement un probleme coded'une certainemaniere, eteprouver des dicultes pour le me^me pro-bleme code d'une autre maniere. Pire, un codage peutfavoriser le temps de calcul d'un solveur, et se montrerau contraire inadapte pour un autre solveur. Dans cetarticle, nous nous concentrons sur l'expression en CNFde contraintes de cardinalite:etant donneun ensembleV de variables propositionelles,etant donnee une valeurentiere k , exactement k variables de V doivente^treeva-lueesa vrai . Nous proposons de nouvelles manieres demodeliser ces contraintes en cherchantagrouper les va-riables dont la semantique est proche. Nousetudions cescodages sur des problemes de diagnostic de systeme aevenements discrets (SED). Des problemes jusqu'ici in-solubles peuvente^treapresent resolusala fois par de sprocedures systematiques ou stochastiques. Les resulta tsmettent egalement en lumiere l'existence d'un codagequi convienne aux deux types d'algorithme.
Analysis of Predictive Algorithms using Mobile Call Traces

The next generation of access technology will ensure wireless connectivity to any one at almost any location using wireless access technology. While Mobile IP is an established technology and is a macro mobility technology, Cellular IP is a sub-division of this and is known as a micro mobility technology. With device portability the communication device moves, with or without the user. Many mechanisms in the network and inside the device have to make sure that communication is still possible while it is moving. Apart from signaling across the wired network, resources have to be employed to accurately track the mobile user. This tracking of the user is inefficient in terms of bandwidth and power consumption. A number of movement prediction methods to alleviate this problem have been proposed for cellular networks. In this paper we will examine some of these and compare them using actual historical mobile call trace data.
ON A SHARP LOWER BOUND ON THE BLOW-UP RATE FOR THE L CRITICAL NONLINEAR SCHRÖDINGER EQUATION

(1.1) (NLS) { iut = −∆u − |u| 4 N u, (t, x) ∈ [0, T ) × R u(0, x) = u0(x), u0 : R → C with u0 ∈ H = H(R ) in dimension N ≥ 1. From a result of Ginibre and Velo [7], (1.1) is locally well-posed in H and thus, for u0 ∈ H, there exists 0 < T ≤ +∞ such that u(t) ∈ C([0, T ), H) and either T = +∞ (we say the solution is global) or T < +∞ and then lim supt↑T |∇u(t)|L2 = +∞ (we say the solution blows up in finite time). (1.1) admits the following conservation laws in the energy space H: L-norm : ∫ |u(t, x)| = ∫ |u0(x)|; Energy : E(u(t, x)) = 12 ∫ |∇u(t, x)| − 1 2+ 4 N ∫ |u(t, x)| 4 N = E(u0); Momentum : Im (∫ ∇uu(t, x) ) = Im (∫ ∇u0u0(x) ) .
Management of Splenic Injury

Traumatic splenic injury is a potentially life-threatening complication of both blunt and penetrating trauma to the abdomen and thorax. The spleen is susceptible to injury in the presence or absence of damage to surrounding viscera and can lead to haemodynamic instability and hypovolaemic shock. This review examines the classification, investigation and management of this condition with both non-operative and operative techniques.
Regional IPM Programs in East Africa : Kenya , Tanzania and Uganda

The East Africa project is conducting research on development of IPM packages for tomato, pepper, passion fruit and coffee in Uganda; tomato, passion fruit and onion in Kenya; and tomato, coffee and onion in Tanzania. Several components of the IPM packages developed were transferred to farmers by organizing farmers‟ field days, workshops and meetings. Some of the notable achievements are identification of bacterial wilt tolerant varieties, introduction of grafting and high tunnel cultivation, and screen house production of seedlings to reduce virus disease incidence in tomatoes, screening for virus disease resistance in passion fruit, and use of arbuscular mycorrhiza fungus, Trichoderma sp. and Bacillus sp. for control fungal and bacterial diseases fruit and vegetable crops. East Africa project has been closely working the global theme projects on Gender, Impact Assessment and International Plant Diagnostic Network.
Individualismo y colectivismo en la gestión de los recursos humanos: un estudio de casos de empresas

Este trabajo arranca de observaciones y preguntas surgidas en trabajos anteriores sobre cambio industrial y sobre insercion laboral. Se pregunta cual pueda ser la variedad de estrategias empresariales en la gestion de recursos humanos y como esas estrategias orientan las practicas dirigidas a la incorporacion de nuevos empleados: el reclutamiento y la seleccion, la formacion y el aprendizaje, la remuneracion y la promocion. La mayoria de la literatura sobre nuevos sistemas de produccion y nuevas practicas de recursos humanos, singularmente la literatura norteamericana sobre management , imagina modelos integros y estables de estas practicas, que resultan de opciones estrategicas asociadas a orientaciones competitivas o a estilos de gestion, y que se configuran como soluciones congruentes con sistemas de empleo en los que la dimension colectiva esta ausente del analisis o es considerada una restriccion. Aqui se presentan los resultados de un estudio de varios casos de empresas industriales ubicadas en Asturias y que representan opciones tipicas de nuevas estrategias de recursos humanos.
Effect of PCO2 changes induced by head-upright tilt on transcranial Doppler recordings.

BACKGROUND AND PURPOSE Transcranial Doppler (TCD) monitoring of mean blood flow velocity (mV) during head-upright tilt can allow testing of cerebral autoregulation. Nonetheless, head-upright tilt can induce changes in the ventilation-perfusion relationship and/or respiratory activity that might influence TCD data. METHODS Forty-eight healthy volunteers underwent monitoring of mV and end-tidal CO2 in the horizontal position and during head-upright tilt. RESULTS Both mV and end-tidal CO2 significantly decreased in orthostasis (P < .01). Linear regression analysis showed a significant linkage between end-tidal CO2 and mV changes (r = .83, P < .01). CONCLUSIONS Changes in ventilation-perfusion ratio and in the respiratory pattern induced by head-upright tilt can significantly influence TCD data by determining a PCO2 decrease.
Caring Behaviors of Preceptors as Perceived by New Nursing Graduate Orientees

This phenomenological study explored the interactions between new nursing graduate orientees and their preceptors during the orientees' professional orientation. Six themes of caring and four themes of noncaring preceptor behaviors emerged through participants' journals and interviews. The six themes of caring preceptor behaviors included advocating, welcoming, including, autonomy with appropriate preceptor presence, making human connections, and genuine feedback. Four themes emerged indicating noncaring preceptor behaviors and included unwelcoming, autonomy with preceptor overpresence or underpresence, and nongenuine feedback.