Miracle-dz/UniFAR-FTUs huggingface dataset:
Protein Expression in Prim ary C olorectal C ancer for Predicting Response to 5-fluorouracil-based C hem otherapy

Purpose: In the treatment of advanced metastatic colorectal cancer, several new agents, such as irinotecan and oxaliplatin, have been developed, which have improved both disease free and overall survivals. Among these agents, 5-fluorouracil (5-FU) still remains one of the most active agents, and the selection of patients who can benefit from 5-FU-based chemotherapy is still important, as those unlikely to benefit could be spared the harmful side effects. The expression levels of thymidylate synthase (TS), thymidine phosphorylase (TP) and p53 have been known to be associated with the clinical response to 5-FU-based therapy as well as the prognosis, and that of vascular endothelial growth factor (VEGF) is associated with poor survival. Materials and Methods: The relationship between the expressions of TS, TP, VEGF and p53 in primary tumors, using immunohistochemistry, and the response of 45 metastatic colorectal cancer patients (M:F=25:20, median age 59 yrs) to 5-FU-based chemotherapy were evaluated. Results: Thirtyseven patients were treated with 5-FU/ LV/irinotecan (FOLFIRI) and 8 with 5-FU/LV/oxaplatin (FOLFOX). The overall response rate was 28.9% (13/45). W hen immunohistochemically analyzed with monoclonal antibodies against TS, TP, VEGF and p53, 55.6% of the patients (25/45) were positive for TS, 48.9% (22/45) for TP, 82.2% (37/45) for VEGF, and 80% (36/45) for p53. There was a significant difference in the intensity of TS expression between the clinical responders and non-responders (p=0.036). In terms of the staining pattern of TS expression, diffuse staining was correlated with a poor response (p=0.012) and poor survival (p=0.045). However, there was no correlation between the expressions of TP, VEGF or P53 and the response to chemotherapy. Conclusion: These results suggest that the expression of TS in primary colorectal cancer might be an important prognostic factor for chemotherapy response and survival, and might be a useful therapeutic marker for the response of chemotherapy. (Cancer Res Treat. 2005;37: 216-222) 󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏
Potassium Channel α and β Subunits Assemble in the Endoplasmic Reticulum*

We have characterized the maturation of Shaker K+ channel protein and the cellular site of assembly of pore-forming α and cytoplasmic β subunits in a transfected mammalian cell line. Shaker protein is made as a partially glycosylated, immature precursor that is converted to a fully glycosylated, mature product. Shaker protein did not mature when transport from the endoplasmic reticulum (ER) to the Golgi apparatus was blocked. Consistent with this finding, only the immature form was sensitive to digestion with endoglycosidase H. These results indicate that the immature protein is core-glycosylated in the ER, whereas the oligosaccharides of the mature protein have been further processed in the Golgi compartment. After inhibiting ER-to-Golgi transport, the oligomeric state of Shaker subunits was assessed by cross-linking in intact cells or by solubilization and sucrose gradient sedimentation. The results indicate that Shaker subunits assemble with each other in the ER. When co-expressed, the Kvβ2 subunit also associated with Shaker in the ER. Assembly with the β2 subunit did not increase the rate or extent of Shaker protein maturation. Our results indicate that the biogenesis of Shaker K+ channels in vivo involves core glycosylation and subunit assembly in the ER, followed by efficient transfer to the Golgi apparatus where the oligosaccharides are modified.
Bayesian Variable Selections for Probit Models with Componentwise Gibbs Samplers

This article considers Bayesian variable selection problems for binary responses via stochastic search variable selection and Bayesian Lasso. To avoid matrix inversion in the corresponding Markov chain Monte Carlo implementations, the componentwise Gibbs sampler (CGS) idea is adopted. Moreover, we also propose automatic hyperparameter tuning rules for the proposed approaches. Simulation studies and a real example are used to demonstrate the performances of the proposed approaches. These results show that CGS approaches do not only have good performances in variable selection but also have the lower batch mean standard error values than those of original methods, especially for large number of covariates.
Inheritance of Strain Instability (Sectoring) in the Commercial Button Mushroom, Agaricus bisporus

The button mushroom, Agaricus bisporus, is a commercially important cultivated filamentous fungus. During the last decade, the button mushroom industry has depended mainly on two strains (or derivatives of these two strains). Using one of these highly successful strains (strain U1) we examined the phenomenon of strain instability, specifically, the production of irreversible sectors. Three “stromatal” and three “fluffy” sectors were compared with a healthy type U1 strain and with a wild-collected isolate. Compost colonization and fruit body morphology were examined. The main objective of this study, however, was to examine the meiotic stability of the sectored phenotype. Single basidiospores were isolated and subjected to a grain bioassay in which the ability to produce sectors was measured. Our results were as follows: (i) basidiospore cultures obtained from a wild-collected isolate showed no tendency to produce sectors; (ii) approximately 5% of the basidiospore cultures obtained from healthy type U1 strains produced irreversible sectors in the grain bioassay; (iii) the five primary sectors examined produced basidiospore cultures, half of which produced normal-looking growth in the grain bioassay and half of which produced some degree of sectoring; and (iv) the one sectored isolate that represented the F2 generation gave ratios similar to the 1:1 ratio observed for the F1 cultures.
High Dose Chemotherapy and Transplantation of Hematopoietic Progenitors from Murine D3 Embryonic Stem Cells

Abstract Differentiating embryonic stem (ES) cells are an increasingly important source of hematopoietic progenitors, useful for both basic research and clinical applications. To date, characteristics of specific factors capable of influencing hematopoietic cell fate from ES cells remains elusive. We report that mMSC Feeder Layer and the combination of VEGF, SCF and TPO strongly promote hematopoietic differentiation. The results showed that the cells induced from ES-D3 expressed hematopoietic progenitor antigens (CD34 and CD117), myelocyte cell antigen (CD11b), erythrocyte cell antigen (Ter119), and transcription factors (Flk-1, GATA-2, SCL, β-H1 and β-major). Furthermore, those induced differentiated cells were injected into female C57BL/6 mice which were treated with high dose topotecan chemotherapy to restore part of their blood system function. We observed rapid white blood cell recovery, which suggested that the infusion of differentiated cells has a positive impact on hematopoiesis. The Sry gene in peripheral blood, bone marrow and spleen of transplanted female mice was confirmed by PCR analysis, which affirmed the existence of the chimera.
Combined eye-head gaze shifts in the primate. II. Interactions between saccades and the vestibuloocular reflex.

The mechanisms of eye-head coordination were studied in two alert juvenile rhesus monkeys. Animals were trained to follow a target light to obtain a water reward and the combined eye-head gaze shifts in response to target steps with a variably sized horizontal components were studied. During a certain random portion of the gaze shifts, a torque motor was used to perturb the head to investigate the operational state of the vestibuloocular reflex (VOR) during the saccadic gaze shift. The effects of perturbing the head were assessed during five different conditions: horizontal target steps ranging from 10 to 80 degrees in amplitude; oblique target steps where the vertical component was larger than the horizontal component; purely vertical target steps 10-40 degrees in amplitude; both horizontal and oblique target steps delivered while the animals' saccades had been slowed by the use of diazepam; and large spontaneous gaze shifts in response to both sounds and visual stimuli. Comparison of perturbed and unperturbed large-amplitude (greater than 40 degrees) gaze shifts indicate that the VOR is turned off for most of the duration of the movement. Nonetheless, there is an apparent interaction between the saccadic eye movement and the head movement, thus, as the head velocity increases, the eye velocity decreases so that gaze velocity remains nearly constant throughout the gaze shift. Since the VOR is turned off when this interaction occurs, it must represent an interaction between the actual eye and head movement motor programs themselves. Although the results were not quite as clear for small saccades (less than 20 degrees), experiments on animals whose saccades had been slowed either by the use of diazepam or by combining a small horizontal component with a large vertical component indicate that the VOR is left on during these smaller gaze shifts. During quite small gaze shifts (less than 10 degrees), the VOR is clearly functioning; however, as the size of the gaze shift is increased, this becomes less clear, and there appears to be a region where the VOR operates with a gain substantially less than normal before it enters the large gaze shift region where the VOR is turned off entirely. (ABSTRACT TRUNCATED AT 400 WORDS)
Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries

Prof. J. A. Rogers Department of Materials Science and Engineering Beckman Institute for Advanced Science and Technology and Frederick Seitz Materials Research Laboratory University of Illinois at Urbana-Champaign Urbana , IL 61801 , USA E-mail: jrogers@illinois.edu Dr. L. Yin, Dr. X. Huang Department of Materials Science and Engineering Beckman Institute for Advanced Science and Technology and Frederick Seitz Materials Research Laboratory University of Illinois at Urbana-Champaign Urbana , IL 61801 , USA Prof. H. Xu CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China Hefei, Anhui 230026 , P. R. China Dr. Y. Zhang, Prof. J. Cheng Department of Materials Science and Engineering University of Illinois at Urbana-Champaign Urbana , IL 61801 , USA Mr. J. Lam College of Liberal Arts and Sciences University of Illinois at Urbana-Champaign Urbana , IL 61801 , USA
Green cell-less design for RF-wireless power transfer networks

This paper studies a new concept so-called green cell-less radio frequency (RF) wireless power transfer (WPT) networks. We consider a scenario in which multiple indoor access points (APs) equipped with outdoor energy harvesters are connected with a central control unit via backhaul links. Further, such APs exploit the harnessed green energy to recharge wirelessly indoor devices under the coordination of the control unit. Considering the network, we focus on AP selection and beamforming optimization to maximize the total energy harvesting (EH) rate. The resulting mathematical problem has the form of mixed-integer optimization that is intractable to solve. Thus, we propose an algorithm to tackle this difficulty. Through numerical results, we show the advantages of the cell-less design over the conventional small-cell one to validate our ideas. In particular, the issue on safety requirements of human exposure to RF radiation is discussed. Finally, potential future research is provided.
The Relationship Between a Leaf-rolling Moth (Dactylioglypha tonica) and Fungi Covering the Cocoon

To discover the relationship between a leaf-rolling moth and the fungi densely covering its cocoons, the rolled nest leaves were collected in two districts in Japan and antibacterial properties of the fungi were examined. Cocoons and fungi isolated from the nest were classified into 5 categories by the growth stages of the insects, and 7 categories based on taxonomic properties and pigment productivity, respectively. The dominant genus was Penicillium in each location. However, the composition of the fungal categories was different and seemed to depend on their circumstances. From all cocoons with larvae, the strains that belonged to the same fungal category and produced the same antibiotic (deoxyherqueinone) were isolated. From these results, the species-specific relationship between the insect and fungi or fungal products was considered to be not extremely tight, and it was suggested the period of the larval spinning of the cocoon is a key stage of this unique relationship.
[Factoranalytic Structure of a Short Version of the Eating Attitudes Test (EAT-13) and Prevalences of Disordered Eating in a Representative German Sample.]

Early detection of disordered eating behavior is a first hint to prevent clinically relevant eating disorders. Screening instruments are aimed at detecting disordered eating behavior at an early stage, to identify risk groups and as necessary initiate treatment. The EAT-13 is an economic screening instrument (13 items), that allows identification of risk groups in big unselected samples with help of determination of sum score. Factorial validity of the EAT-13 and the suitability for different ages were determined in a representative sample of the German population (N=2 508). Furthermore prevalence of disordered eating behavior was assessed in the sample. Results show that the EAT-13 is a reliable and economic screening instrument that is eligible to select risk groups. An inspection of criterion validity shall be conducted in further studies.
Low-cost gas chromatography with gas sensor array for rapid tests in food industry processes

A portable low-cost gas chromatographic measurement system will be presented. The system consists of a novel chromatographic column - which enables measurements at room temperature and ambient air - with a downstream micro machined gas sensor array and offers the separation and identification of volatile organic compounds. The targeted application is the monitoring of flavours directly during food processing. The measurement system was characterized by using flavours like methyl pyrrole, hexanal, pinene, ethyl butyrate and limonene as test gases. Reliable and reproducible identification of the gases in the concentration range of a few ppb has been achieved.
Probabilistic Data Consistency for Wide-Area Applications

Wide-area applications, such as electronic commerce, groupware, directory service etc., rely on distributed data management services which often employ data replication to meet availability and response time constraints imposed by the target domains. Since many of these applications can tolerate some staleness in the data they access, the constraints may be better met by exploiting relaxed data consistency among copies in the system. However, in the current Internet architecture, it is nearly impossible to provide deterministic guarantees for the bounds on data inconsistency among copies. We present an approach for providing probabilistic data access guarantees while maintaining availability and timing predictability. Our model makes few assumptions regarding the underlying infrastructure. In fact, a novel feature of our approach is that it is independent of the underlying replication scheme. We focus on modeling the update patterns of the servers and modifying the data access mechanisms. Our model guarantees, with a certain probability P , that if a client requests the value of an object, the value returned by the system, if any, will be temporally consistent with the newest copy of the same object in the system. That is, from the perspective of a client, the system provides a probabilistic data consistency guarantee.
Peripheral and central cholecystokinin receptors regulate postprandial intestinal motility in the rat.

Postprandial cholecystokinin (CCK) has been suggested as an important mediator of disruption of migrating myoelectric complexes (MMC) after a meal. However, the role of CCK in regulating small intestinal motility in rats and the participation of central and/or peripheral CCK-A and B receptors in CCK actions, are still unclear. For this study, Sprague-Dawley rats were prepared with electrodes in the small intestine, a catheter in the jugular vein and an intracerebroventricular (i.c.v.) cannula. Postprandial disruption of the MMC was blocked by the i.v. infusion of the CCK-B antagonist L-365,260 (2 x 10(-7) mol/kg), but not by the infusion of the CCK-A antagonist L-364,718. When administered i.c. v. , L-364,718 (2.25 x 10(-9) mol), but not L-365,260, restored the MMC pattern. The i.v. infusion of CCK-8 (1-3 x 10(-9) mol/kg) or CCK-4 (10(-7) mol/kg) disrupted the MMC pattern. CCK-8 effects where prevented by the i.v. infusion of either L-364,718 or L-365,260. Administered i.c. v. , only the antagonist L-364,718 prevented CCK-8 disruption of the MMC. These results suggest that CCK-mediated motor changes after a meal are due to stimulation of peripheral CCK-B receptors. CCK also induces a release of central CCK that through CCK-A receptors participates on MMC disruption.
Satellite-to-indoor broadband channel measurements at 1.51 GHz and 5.2 GHz

To investigate the satellite-to-indoor wave propagation channel for navigation applications the German Aerospace Center conducted broadband channel sounder measurements using a mobile crane as transmitter platform with the receiver being placed indoors. Using this setup, measurements were performed for L-band at 1.51 GHz and C-band at 5.2 GHz with a broadband signal of 100 MHz bandwidth. Results are given in terms of power delay profile, root-mean-square delay spread and mean delay.
Fraud detection in telecommunication: A rough fuzzy set based approach

Telecommunications fraud is increasing dramatically resulting in costing operators almost $60 billion each year. Due to the increase of bandwidth of 3G mobile communication equipment, the fraud can be in terms of network, commercial, customer or even staff and all will remain keys in assessing 3G fraud risk. Current methods such as artificial neural network and statistic methods used to detect fraud in 2.5G network canpsilat effectively extract intrinsic characteristics from huge database. This paper presents a novel rough fuzzy set based approach to detect fraud in 3G mobile telecommunication network. It analyzes the scenarios in 3G network including subscription fraud and superimposed fraud and profile and confirms the parameters to detect the scenarios. A rough fuzzy set based model to reduce the parameters in each scenario and get the refined characteristics. A rule based system called Citi FMS was designed to detect abnormities and alarm. The proposed system presented a framework used for 3G fraud risk including subscription and superimposed fraud.
The long-term effect of lockouts on alcohol-related emergency department attendances within Ballarat, Australia.

INTRODUCTION AND AIMS Alcohol has consistently been demonstrated to increase levels of aggression and violence, particularly in late night licensed venues. Since August 2003, Ballarat (a regional city of approximately 95,000 inhabitants, in Victoria, Australia) has implemented a 3:00 AM 'lockout' with the goal of reducing alcohol-related harms. This paper is the first long-term analysis of the effect of this type of intervention on emergency department (ED) attendances. The aim of this paper is to examine the effectiveness of a lockout intervention within the city of Ballarat, Victoria on alcohol-related ED presentations. DESIGN AND METHODS This paper examines alcohol-related injury frequencies pre- to post-lockout intervention in Ballarat, Victoria, from 1999 to 2009, as indicated by ED International Classification of Diseases codes for acute alcohol intoxication and assault. These data are further compared with similar data from Geelong, Victoria, as a control. RESULTS A small reduction in alcohol-related assaults and intoxication rates within Ballarat occurred before and after the introduction of the lockout. However, after this decline these rates steadily increased, surpassing Geelong by 2005. DISCUSSION AND CONCLUSIONS There is no discernible long-term impact on alcohol-related ED attendances of the lockout intervention in Ballarat. As such, other interventions may be more appropriate to reduce alcohol-related ED attendances.
Prototipo sostenible para laboratorio remoto

El articulo describe los trabajos y disenos realizados para construir una maqueta pensada para la realizacion de practicas remotas en el ambito de la automatica. El diseno tiene en cuenta diferentes aspectos de sostenibilidad y simplificacion del desarrollo del laboratorio remoto.
Predictive Validity of Variables Used to Select Students for Postgraduate Management Courses

The present study set in the United Kingdom examined the predictive validity of variables used to select graduate students into postgraduate management programs at a UK business school. 303 postgraduate students completed a cognitive ability test (MD5, Mental Ability Test), a questionnaire to assess perceptions of self-efficacy to succeed on the program, and reported their performance on their first (undergraduate) degree. Students completed these measures at the start of the programs. Each program comprised 12 modules, which all students were required to complete successfully. Students' performance was measured by the average grade obtained over the 12 modules. Multiple regression indicated that only 22% of the variance (Adjusted R2 = .22, p < .001) in students' performance was predicted significantly by cognitive ability scores. Results show that neither performance on first degree nor scores for self-efficacy showed a significant relationship to the criterion measure. Findings from the present study suggest that in the UK, the use of cognitive ability tests may play a significant role in the selection of students into postgraduate programs. Nonsignificant self-efficacy and performance relationships are ascribed to unclear knowledge of the demands of the program. We suggest that there is need for further research to examine factors related to performance.
Book Review of "More Trouble With Maths" (2017) by S. Chinn

Journal of Numerical Cognition, 2017, Vol. 3(3), 723–725, doi:10.5964/jnc.v3i3. 145 Published (VoR): 2018-01-30. *Corresponding author at: 1912 Speedway Stop D5300, Austin, TX 78712, USA. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, CC BY 4.0 (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.