Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of pre-exercise energy drink on the exercise endurance in young active adults

The effect of a pre-exercise energy sport drink on the exercise performance was examined in twenty recreationally active 1 st yr medical students. A single-blind, case-controlled research study design was conducted. Subjects underwent two testing session separated by 7 days, consisted of VO2max, RPE scale, HRmax as well as incremental test to exhaustion on motorized treadmill. Before the second trial, they were provided with Pre-exercise energy drink supplement (commercially marketed as RED BULL energy drink). Statistical analysis by student’s paired t test revealed significant difference was observed in VO2max, RPE scale, Exhaustion time and HRmax (p<0.05) after ingestion of Pre-Exercise energy drink. The present study indicate that a high energy drink consumed 30 minutes before exercise can enhance exercise performance by increasing the total time to fatigue during incremental testing.
The musculoskeletal contribution to the evolution of chronic lumbopelvic pain: 1. The lumbar spine and pelvis

Where there is no proven infection or obvious local pathology, the occurrence of chronic pelvic pain syndrome (CPPS) may involve contributions from the musculoskeletal, neurological, urological, gynaecological and immune systems. In the first part of this article, the potential musculoskeletal contributions of the lumbar spine and pelvis to CPPS are described. This provides the practitioner with a systematic assessment to identify the postural alignment strategies, habitual movement patterns and interactions of the lumbopelvic cylinder that may be contributing to an individual’s presenting condition. However, persistent pain is also associated with changes in the central nervous and immune systems, and therefore, we need to be reminded that the purely structural-pathology-based model for explaining CPPS is outdated. Furthermore, since CPPS is often associated with negative cognitive, sexual and emotional consequences, these may also need to be addressed in order to provide optimum care for the patient.
Foot Self Care in Diabetic Patients

OBJECTIVE: Foot ulcer in diabetic people has a negative effect on their quality of life. It can decrease social activities, and increase stress. It can also limit doing job tasks, and increase life financial burden and high medical expenses. So examination of feet and considering foot care in these patients are essential. MATERIALS AND METHODS: This analytic-descriptive research was performed on 80 hospitalized diabetic patients in 2009 using questionnaires to assess their demographic data and self foot care. The subjects were selected in a convenience method. RESULTS: Only 7.5% of subjects had been educated about self care to prevention of foot ulcer. Practice level in self care behaviors of 15% of them was good, 60% moderate and 25% low. There was a significant relationship between sex and the amount of foot care and between the histories of foot ulcer existence and the amount of foot care according to chi-square test. CONCLUSION: Preventive measures can decrease the incidence of foot ulcer in diabetic people so it seems that providing educational programs about the ulcer and prevention methods is necessary to improve these patients' quality of life.
Controlled Trial of Direct Physician Order Entry

Objective: Direct physician order entry (POE) offers many potential benefits, but evidence suggests that POE requires substantially more time than traditional paper-based ordering methods. The Medical Gopher is a well-accepted system for direct POE that has been in use for more than 15 years. The authors hypothesized that physicians using the Gopher would not spend any more time writing orders than physicians using paper-based methods. Design: A randomized controlled trial of POE using the Medical Gopher system in 11 primary care internal medicine practices. Measurements: The authors collected detailed time use data using time motion studies of the physicians and surveyed their opinions about the POE system. Results: The authors found that physicians using the Gopher spent 2.2 min more per patient overall, but when duplicative and administrative tasks were taken into account, physicians were found to have spent only 0.43 min more per patient. With experience, the order entry time fell by 3.73 min per patient. The survey revealed that the physicians believed that the system improved their patient care and wanted the Gopher to continue to be available in their practices. Conclusions: Little extra time, if any, was required for physicians to use the POE system. With experience in its use, physicians may even save time while enjoying the many benefits of POE.
Coronary artery events in Thai patients with psoriasis using Framingham and Ramathibodi–Electricity Generating Authority of Thailand risk scores

Abstract Background soriasis is an independent risk factor for cardiovascular disease. Several tools such as Framingham score (FRS) and Ramathibodi-Electricity Generating Authority of Thailand (RAMA-EGAT) score have been developed to predict the 10-year risk of coronary artery disease (CAD) and death. However, there are only few studies determine CAD risk using FRS and RAMA-EGAT score in Asian patients with psoriasis. Objectives To investigate the risk of CAD events using the FRS and RAMA-EGAT score in Thai patients with psoriasis. Methods Predictive factors that associated with intermediate and high risk (≥10%) of CAD events within 10-year were determined. Variables, including age, sex, blood pressure, cholesterol, high-density lipoprotein, diabetes mellitus, waist circumference, smoking, and alcohol intake were used to calculate scores. Results Of 145 patients with psoriasis and a mean age of 48.1 ± 14.1 years, 72 patients were men. Using FRS and RAMA-EGAT, 25% and 13% of the patients, respectively had a ≥10% risk of developing CAD events. A higher risk of CAD was predicted when severe psoriasis was considered. The duration of disease and treatment were associated with an increased risk of CAD using the FRS and RAMA-EGAT score by multivariate analysis. Conclusions A substantial portion of our patients had a CAD risk ≥10%, with significant relationship with duration of disease and treatment. Early screening of CAD and appropriate treatments of psoriasis may be helpful for preventing CAD in patients with psoriasis.
Differences of Cardiac Efficiency of Rural and Urban Students

The purpose of the study was to identify the physical fitness components of rural and urban students. 40 students, 20 rural and 20 urban from various colleges of Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra India were selected as a subjects for the study. Execution criteria were the presence of chronic medical condition such as asthma, heart disease or any other condition that would put the subject at risk when performing the physical fitness components. The data was collected by use of measurements of height & weight as well as by application of tests like, running, jumping, steeping, setups etc. The data was analysed with the help of statistical procedure in which arithmetic mean, standard deviation and t - test were employed. The mean age of rural students were 21.03 (+ 3.11) years, height were 171.33 (+ 5.22) cm. and the weight were68.48 (+ 3.91) kg. On other hand the mean (+ S.D.) age of the urban students were 21.99 (+ 3.72) years, height 171.66(+ 8.29) cm. and weight 67.92 (+ 3.76). Significant difference was found in endurance ability (t=5.96, p<.05) between rural and urban students. Rural students were found to have got more cardio vascular efficiency as compare to urban students.
Monitoring heart transplant recipients in order to investigate immunosuppressive drug absorption using pharmacokinetics parameters and its’ correlation with nephrotoxicity

An appreciated and well-recognized treatment option for end stage heart failure verified as heart transplantation . Life-long immunosuppression suggested to be necessary due to the risk associated to rejection of transplanted heart by the recipient’s body. This study aimed to monitor heart transplant recipients in terms of immunosuppressive drug absorption using pharmacokinetics parameters and its’ correlation with nephrotoxicity. Heart transplanted recipients at Chamran Hospital Isfahan, Iran was studied. All data and factors that could affect immunosuppressive pharmacotherapy were noted in Excel and analyzed by SPSS. There were 10 heart transplanted patients from 24 November 2013 to 24 August 2018. Study population was comprised of 8 male and 2 female, with a minimum of 24 and a maximum of 54 years, the mean age ± SD was 38.7 ± 10.8 years old. Available data related to the hospital stay showed a minimum of 10, a maximum of 56 and a mean of 31 ± 14.9 days. Pharmacotherapy was based on cyclosporine, mycophenolate, acyclovir, prednisolone, valsartan, pantoprazole and others. Higher risk of infectious complications and malignancies after heart transplantation and a lower risk for acute or chronic rejection could be achieved by monitoring immunosuppressive drugs associated to nephrotoxicity or neurotoxicity based on well-structured program. Further studies in this direction seem to be advantageous
More efficient use of HER targeting agents in cancer therapy

Cancer treatments have remarkably improved over the past years since targeted therapies and immunotherapy have been introduced to the field of oncology. The benefit of these new therapies is often limited, however, by de novo or acquired therapy resistances, which should be noticed when making clinical decisions. In this current work, we studied the prognostic and predictive values of several immunological markers in metastatic HER2-positive breast cancer treated with trastuzumab, because trastuzumab is still given to patients according to the HER2 status only, without certainty of tumor response. We also determined the role of HER2 and HER3 for cancer stem cells (CSC) in ALK translocated non-small cell lung cancer (NSCLC) cell lines since the CSCs are causing therapy resistance and cancer recurrence. The results demonstrated that a high number of cytotoxic T cells, together with a high number of M1-like macrophages in the center of the tumor (CT), are promising and independent prognostic factors in HER2-positive breast cancer. These markers together also can predict the progression of the disease and the length of trastuzumab discontinuation in tumor response. Expression of HER2 and HER3 increased the stem-like properties of ALK translocated NSCLC cells, which were decreased when the expressions were downregulated. HER2-HER3-dependent CSCs also mediated the ALK therapy resistance. In conclusion, this study suggests that patients with a favorable immunological tumor profile (high number of cytotoxic T cells and M1-like macrophages in the CT) could be treated in a lessintensive manner, that trastuzumab discontinuation could be feasible for these patients, and that targeting of HER2 and HER3 receptors can lead to more effective killing of cancer stem-like cells and should be further studied.
Neonatal seizures: clinical manifestations and etiology

Background Neonatal seizures or fits are signs of central nervous system (CNS) diseases, metabolic disorders, or other diseases disrupting the CNS. Neonatal seizures are poorly classified, under-recognized and often difficult to treat. It is important to recognize the type of neonatal seizures that might be the only sign of a CNS disorder. Objective To recognize the type and etiology of neonatal seizures in several hospitals in Jakarta. Methods This was an observational case series study on full-term and preterm infants who had seizures during hospitalization in Cipto Mangunkusumo, Harapan Kita, and Fatmawati Hospitals between January-June 2005. Neonatal seizures were defined as seizures occurring in the first 28 days of life of a term infant or 44 completed weeks of the infant’s conception age of preterm infant. Results There were 40 neonates who born within the study period and had seizures. Girls were outnumbered boys. Most neonates were full-term with birth weight of more than 2500 grams. Analyses were done on 38 neonates with epileptic and non-epileptic seizures, while the other two who had mixed clinical manifestation were not included. Most seizures occurred in the first 3 days of life (23/38). The most common type was focal clonic (12/14) followed by general tonic (11/24) and motor automatism or subtle (10/24). The most common etiology was hypoxic ischemic encephalopathy (HIE) (19/38) followed by metabolic disturbances, mainly hypocalcaemia (11/38). Conclusion Common types of seizures in neonates were focal clonic, general tonic, and motor automatism (subtle). The most common etiology was HIE followed by metabolic disturbances, mainly hypocalcaemia [Paediatr Indones 2006;46:266-270].
Roles for PLD2 in growth factor-mediated signal transduction in EL4 lymphoma cells

1. Yaziji H, Gralow JR, Chahal MS, Zapf M, Thomazy V, Davies P, Gown AM. Her-2/neu detection by fluorescence in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR) in breast cancers with low level overexpression by immunohistochemistry. Proceedings of the American Society of Clinical Oncology. 20, 2001. 2. Rehman A, Chahal MS, Daoud SS. Identification and validation of SIVA gene expression in human colon carcinoma cells: A Pharmacogenomic study. 4 Inland Northwest Cancer Conference. 2002. 3. Rehman A, Chahal MS, Pommier Y, Daoud SS. PRIMA-1 restores the p21 transactivation by tumor suppressor p53 in breast cancer cells. Proceedings of American Association of Cancer Research. 44, 2003. 4. Chahal MS, Rehman A, Daoud SS. Role of Glypican-3 (GPC-3) in Cisplatin resistance in ovarian cancer. Proceedings of American Association of Cancer Research. 44, 2003. 5. Betelihem S, Tang X, Bruce JE, Rehman A, Chahal MS, Daoud SS. Proteomic analysis of S100A4 partner proteins in human colon carcinoma cells. Proceedings of American Association of Cancer Research. 45, 2004. 6. Chahal MS, Meier KE. Effects of Phospholipase D2 overexpression in EL4 cells. FASEB Summer Conference on Phospholipases. 2004. 7. Chahal MS, Huynh P, Knoepp SM, Xie Y, Meier KE. Role for phospholipase D2 in tumorigenesis in EL4 lymphoma cells. Experimental Biology (FASEB). 2005. 8. Chahal MS, Huynh P, Rubio MV, Meier KE. PLD2 enhances EGF response in EL4 lymphoma cells. Experimental Biology (FASEB). 2006. 9. Chahal MS, Brauner D, Meier KE. PLD2 and EGFR: Identification of a Novel Relationship. Experimental Biology (FASEB). 2007.
Closed lateral internal sphincterotomy under local anaesthesia: A day surgery procedure

Background: Chronic anal fissure is a common anal canal disorder which is more common in females. Closed lateral internal sphincterotomy is one of the surgical options for treatment of chronic fissure in ano. It heals the fissure by decreasing anal spasm, pain and smooth defecation. Lateral internal sphincterotomy under local anaesthesia is the surgery of choice performed as a day surgery procedure.
Prenatal care utilization and infant health in Botswana

Despite the freely and publicly provided health care in Botswana, the proportion of low birth weight infants increased from 8% to 13% during 2000-2007 period. The latter rate was among the highest in the WHO African region and upper middle-income countries and may question the effectiveness of care. Using the 2007/08 Botswana Family Health Survey data collected by Statistics Botswana, the paper jointly estimates the adequate prenatal care utilization (input demand) and infant birth weight (outcome) functions through the treatment effect model, which accounts for the binary nature of the endogenous regressor. As birth weight information is not available for all infants, we also estimate a Heckman sample selection model to account for potential bias. Estimating models for rural and urban samples separately, we find that lower levels of mother`s education reduces the likelihood to both adequately utilize prenatal care and report infant birth weight. The likelihood for prenatal care utilization increases with the probability of a care facility being sufficiently close and availability of care facilities. Adequate prenatal care utilization is positively associated with birth weight and failing to account for endogeneity reduces its effect. On average, birth weight increases by 0.67, 0.73 and 0.64 kg in full, urban and rural samples respectively.
Idiopathic multilocular thymic cyst-an incidental anterior mediastinal mass

Acquired thymic cyst are multilocular and they occur de novo or in association with mediastinal neoplasm, systemic autoimmune diseases and trauma. Here, we report a case of acquired multilocular thymic cyst due to non-specific inflammatory etiology in a 42-year old gentleman and our approach to diagnosis and management of anterior mediastinal mass. With no specific clinical symptom, he was diagnosed with anterior mediastinal mass incidentally by imaging studies. Definitive diagnosis of multilocular thymic cyst was obtained by tissue diagnosis of the anterior mediastinal mass resected during the surgery.
Wirelessly Observed Therapy to Optimize Adherence and Target Interventions for Oral Hepatitis C Treatment: Observational Pilot Study

Background A fixed-dose combination of ledipasvir/sofosbuvir (LDV/SOF) is efficacious in treating chronic hepatitis C virus (HCV) infection; however, objective adherence to prescribed regimens in real-world clinical settings has not been well studied. Objective This study aimed to evaluate adherence and virologic outcomes in patients with chronic HCV infection treated with LDV/SOF using a novel digital medicine program that directly measures drug ingestion adherence. Methods This prospective, observational, open-label, single-arm pilot study was conducted at 2 clinical research sites and followed patients with HCV infection who were prescribed LDV/SOF along with an ingestible sensor. Patients were treated for 8 or 12 weeks. The main outcomes were ingestion adherence, medical interventions, virologic response, safety, and patient satisfaction. Results Of the 28 patients (mean 59 years, SD 7), 61% (17/28) were male, 61% (17/28) were non-Caucasian, and 93% (26/28) were treatment naïve. All 28 had genotype 1 HCV, and of these, 27 completed an 8- or 12-week treatment. Patients used the digital medicine program for 92% of the expected days; the overall mean ingestion adherence rate was 97%. Providers used the digital medicine program data for same-day medication therapy management in 39% (11/28) of patients. End-of-treatment response was achieved in all the available 21 of 28 patients. Sustained virologic response at 12 weeks or more was achieved in 26 of 28 patients; of the 2 patients who relapsed, one had less than 90% adherence and the other had greater than or equal to 95% adherence, lending insights into reasons for treatment failure. A total of 4 subjects reported nonserious adverse events, which were resolved. Conclusions The findings of this study suggest that digital medicines can be used for wirelessly observed therapy to support adherence to antiviral HCV therapy, reduce unnecessary medication wastage and retreatment costs, and potentially optimize sustained virologic response rates, especially in populations at high risk for nonadherence.
Perzistentna infekcija uzrokovana klamidijom trahomatis – prikaz bolesnice

Infekcija klamidijom trahomatis na~e{}a je spolno prenosiva bakterijska infekcija u svijetu. Ve}ina zara`enih ima asimptomatsku infekciju, {to zna~i da se bolest otkrije tek nakon {to nastanu komplikacije, a zara`ena osoba dugo ostaje izvor infekcije. Prikazali smo 67-godi{nju bolesnicu s asimptomatskom infekcijom, kod koje je obrisak endocerviksa bio pozitivan na C. trachomatis. Bolesnica je ve} lije~ena azitromicinom peroralno radi infekcije C. trachomatis. Nakon lije~enja imala je negativan nalaz obriska endocerviksa na C. trachomatis. Sada se opet lije~i azitromicinom parenteralno i otpu{ta iz bolnice. Nakon mjesec dana kontrolni obrisak cerviksa je ponovno bio pozitivan na C. trachomatis. Primijenjena je terapija ofloksacinom u trajanju od 14 dana, nakon koje je kontrolni obrisak negativan. Ne mo`emo sa sigurno{}u re}i da li se kod bolesnice radilo o reinfekciji, reaktivaciji perzistentne klamidijske infekcije ili razvoju soja rezistentnog na azitromicin.
P4687Relevance of TAPSE and FAC, and their relationship to PASP as echo-derived measures for RV-PA coupling in heart failure: a comparative analysis with invasive RV-pressure volume loop data

Right ventricular (RV) to pulmonary artery (PA) coupling (C), quantified by pressure volume (PV) loop analysis, predicts RV function, and is independently associated with long term survival in systolic heart failure (HFrEF). However, the PV loop technique is invasive and complex to carry out, especially when used to do RV functional analyses. Different echo-surrogate parameters are proposed to measure RV-PA-C, such as the tricuspid annular plane systolic excursion, TAPSE/PAsystolic pressure (SP) and FAC (fractional area change)/PASP as the most promising parameters. However, up to now, no validation of these non-invasive coupling indices with the invasive gold standard method of RV-PV-loops has been done. In 111 patients with advanced HFrEF (Post-hoc analysis of Magdeburger CRT Responder Trial, DRKS00011133), echo-derived TAPSE and FAC, and their relationship to PASP were related to the RV PV-loop-derived parameters of intrinsic RV contractility (Ees), pulmonary load (Ea), and the RV-PA-C efficiency (Ees/Ea) by linear regression analysis. Within a MRI substudy (n=49 patients) we examined the relationship of pure longitudinal contraction (MRI-TAPSE) and radial free wall to septum contraction (area change of 5 RV segments from tricuspid valve to apex in the short axis view) to the invasive RV-PA-C. The MRI analysis demonstrated that radial RV contraction (R2=0.77, p<0.001) correlated better to invasive RV-PA-C than pure longitudinal shortening (R2=0.37, p<0.001) (radial vs. longitudinal: p<0.00). Echo data for the entire patient cohort confirmed the MRI data. The FAC (R2=0.8, p<0.001) was significantly better associated with RV-PA-C than TAPSE (R2=0.57, p<0.001) (TAPSE vs FAC, p<0.001). Placing TAPSE or FAC into a quotient with PASP did not at all (TAPSE vs. TAPSE/PASP, p=0.1) or significantly attenuated (FAC vs. FAC/PASP R2=0.8 vs 0.58, p<0.001) their association to RV-PA-C. However, FAC/PASP and TAPSE/PASP correlated significantly better with global afterload (Eea), PA compliance, and pressure volume area (PVA), (p<0.001). In ROC analysis for all-cause mortality, all 4 tested parameters were prognostic relevant, however, with higher AUC values for FAC/PASP (AUC=0.74, p<0.001) and TAPSE/PASP (AUC=0.74, p<0.001) than for single TAPSE (AUC= 0.71, p=0.001) or FAC (AUC=0.7, p=0.001). Within a multivariate Cox regression analysis, only the FAC/PASP remained an independent predictor for long term survival. FAC, an echo parameter that includes a predominant radial with a smaller part of longitudinal contraction, correlated significantly better to the invasively derived RV-PA-C-ratio than pure longitudinal RV shortening (TAPSE). Combining FAC or TAPSE with PASP did not improve the non-invasive RV-PA coupling information. However, it provided more comprehensive information on pulmonary vascular load and RV oxygen consumption, which seems to be translated into a higher prognostic power. scientific grant from Boston Scientific