Miracle-dz/UniFAR-FTUs huggingface dataset:
JAK -2V617F Mutation in Acute Leukemia (South Egypt Experience)

Aim: To search for JAK2V617F mutation in patients with acute myeloid and acute lymphoblastic leukemia in south Egypt. Study Design: JAK2V617F mutation detected by amplification refractory mutation system (ARMS) -PCR. Place and Duration of Study: Department of clinical pathology and department of medical oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt, between December 2010 and December 2012. Method: We included 90 patients (58 men and 32 women; age range 2-67 years) with denovo acute leukemia (30 acute myeloid leukemia and 60 acute lymphoblastic leukemia), JAK-2 V617F mutation using ARMS-PCR was done for all the patients. Results: JAK-2 V617F mutation was absent in all of the studied patients. Conclusion: Our results confirm the finding published previously which reported that JAK2 V617F mutation is very rare or absent in acute leukemia.
A retrospective study of fungal corneal ulcer from the western part of Uttar Pradesh

Background: Infectious keratitis is a major cause of avoidable blindness worldwide. Fungus is an important aetiological agent of infectious keratitis following corneal trauma with vegetative matter. This infection should be promptly treated to limit the morbidity and dangerous sequelae. The purpose of this study was to detect causative agents from corneal scrapings and to identify the predisposing factors of mycotic keratitis. Methods: Corneal scrapings were taken in full aseptic precautions in total 112 suspected patients for fungal etiology and were subjected to direct examination by 10% KOH mount, gram stain and culture. Results: A total 112 cases of suspected corneal ulcers were subjected to KOH mount to detect fungal elements in corneal scraping and culture to isolate aetiological agents. In our study 29 (25.8%) samples were found positive in KOH mount and fungus was isolated from the all KOH positive samples. Males were more commonly affected and were mostly in the age group of 30-50 years. Fusarium species was the most common fungus isolated followed by Aspergillus species. Conclusion: Mycotic keratitis is a serious problem usually following corneal trauma, it requires rapid detection and identification of fugal agents for treatment to prevent disastrous consequences.
Firm R&D Behavior and Evolving Technology in Established Industries

One of the key mechanisms of firms' strategic renewal is R&D, and a key driver of the intensity of R&D is industry context. A number of theories develop propositions linking industry factors to firm R&D behavior, but these theories lack consensus. To date, empirical tests have been unable to resolve the competing predictions because of lack of time-varying measures of technology. We create new measures for technology and then conduct a test of the competing theories. Our results indicate that the data best match a model of innovative behavior in which firms invest in R&D principally to regain eroded advantage rather than to pursue the new frontier.
IoT-based Smart Parking System for Sporting Event Management

By connecting devices, people, vehicles and infrastructures everywhere in a city, governments and their partners can improve community wellbeing and other economic and financial aspects (e.g., cost and energy savings). Nonetheless, smart cities are complex ecosystems that comprise many different stakeholders (network operators, managed service providers, logistic centers.) who must work together to provide the best services and unlock the commercial potential of the IoT. This is one of the major challenges that faces today's smart city movement, and more generally the IoT as a whole. Indeed, while new smart connected objects hit the market every day, they mostly feed "vertical silos" (e.g., vertical apps, siloed apps.) that are closed to the rest of the IoT, thus hampering developers to produce new added value across multiple platforms. Within this context, the contribution of this paper is twofold: (i) present the EU vision and ongoing activities to overcome the problem of vertical silos; (ii) introduce recent IoT standards used as part of a recent Horizon 2020 IoT project to address this problem. The implementation of those standards for enhanced sporting event management in a smart city/government context (FIFA World Cup 2022) is developed, presented, and evaluated as a proof-of-concept.
SAT0185 Efficacy and safety of abatacept in lupus nephritis

Background The evaluation of abatacept (ABA), a modulator of T-cell costimulation, in lupus nephritis (LN) was supported by favorable preclinical studies in murine LN. Objectives To compare the efficacy and safety of IV ABA to placebo (PBO) on a background of mycophenolate mofetil (MMF) and steroids in a 12-month Phase II/III multicenter, double-blind, study of patients (pts) with active Class III or IV LN, including exploratory, post-hoc, and subset efficacy analyses. Methods 298 pts received PBO, ABA 30 mg/kg (30/10), or ABA 10 mg/kg (10/10) in a 1:1:1 ratio on Days 1, 15, 28, 57; thereafter, all ABA pts received 10 mg/kg through Week 48. Prespecified efficacy outcome measures: a) Primary: time to complete response (CR) (CR: eGFR within 10% of preflare/screening; urine protein/creatinine ratio [UPCR] <0.26 g/g; inactive urine: confirmed at 2 consecutive visits); b) CR at Week 52; c) renal improvement (RI) (RI: UPCR <50% of preflare/screening; no worsening of eGFR; inactive urine); d) renal response (RR) (RR: serum creatinine ≤125% of baseline [BL]; UPCR <50% of BL and <3.0 g/g if nephrotic, otherwise <1.0 g/g). Post-hoc efficacy endpoint: CRrev (defined post-hoc to account for renal function misclassifications): eGFR ≥90% of preflare/screening, otherwise same as CR. Results Time to confirmed CR did not differ between groups (p=0.549 and 0.422 for ABA 10/10 and 30/10 vs PBO). Efficacy at Week 52 is shown (Table). Subset analyses of 122 nephrotic pts (BL UPCR >3.0 g/g) found approximately 20–30% greater reduction in mean UPCR. Safety, assessed as deaths, serious adverse events (SAEs) and serious infections, was similar across groups. AEs were generally mild, self-limited and similar in frequencies across groups, with the exception of Herpes zoster (reported in 2.0%, 11.1%, 8.1% of PBO, ABA 10/10, ABA 30/10, respectively). Post-hoc subset analyses suggested Asian race and early reduction of proteinuria (8–12 weeks) were associated with response (CRrev and RR at Week 52) in all groups. Efficacy: Treatment group Placebo ABA 10/10 ABA 30/10 Treated N=100 ABA 10/10 N=99 N=99 Confirmed CR at Month 12, % 3.0 3.0 5.1 CR at Month 12, % 8.0 10.1 10.1 RI at Month 12, % 55.0 52.5 55.6 RR at Month 12, % 33.0 39.4 45.5 Post-hoc: CRrev at Month 12, % 12.0 22.2 15.2 Conclusions Abatacept and PBO, administered on a background of MMF and steroids to pts with LN, exhibited similar safety profiles, time to confirmed CR, and proportion with CR and RI. Exploratory and post-hoc analyses indicated more complete (CRrev) and renal (RR) responders with abatacept compared to PBO. Disclosure of Interest R. Furie Grant/Research support from: Bristol-Myers Squibb, Consultant for: Bristol-Myers Squibb, K. Nicholls: None Declared, T. Cheng: None Declared, F. Houssiau: None Declared, R. Burgos-Vargas Grant/Research support from: Bristol-Myers Squibb, Consultant for: Bristol-Myers Squibb, S. Chen: None Declared, J. Hillson Employee of: Bristol-Myers Squibb, S. Meadows-Shropshire Employee of: Bristol-Myers Squibb, M. Kinaszczuk Employee of: Bristol-Myers Squibb, J. Merrill Consultant for: Bristol-Myers Squibb
Measurement and Evaluation in Physical Health and Recreation Education

local organizations interested in marriage counseling and describes the functioning of these services. This volume is a clear presentation of a well developed and complete program which includes direct counseling, work with and through community agencies, teaching of students in marriage counseling, and research. It is of value to all persons concerned with the problems of the family today. For public health workers its emphasis on prevention will be especially well accepted. ELIZABETH P. RICE
Putting the Screen in Screening

Alcohol is strongly linked to the leading causes of adolescent and adult mortality and health problems, making medical settings such as primary care and emergency departments important venues for addressing alcohol use. Extensive research evidence supports the effectiveness of alcohol screening and brief interventions (SBIs) in medical settings, but this valuable strategy remains underused, with medical staff citing lack of time and training as major implementation barriers. Technology-based tools may offer a way to improve efficiency and quality of SBI delivery in such settings. This review describes the latest research examining the feasibility and efficacy of computer- or other technology-based alcohol SBI tools in medical settings, as they relate to the following three patient populations: adults (18 years or older); pregnant women; and adolescents (17 years or younger). The small but growing evidence base generally shows strong feasibility and acceptability of technology-based SBI in medical settings. However, evidence for effectiveness in changing alcohol use is limited in this young field.
Patient characteristics and clinical activities at a British military department of community mental health

AIMS AND METHOD To describe patient characteristics and clinical activities at a British military department of community mental health (DCMH). Data were drawn from a clinical database over a 1-year period ( n =409). RESULTS Mean age was 29 years, 50% were single and 76% were from the junior ranks. Women were over-represented compared with the wider military population. Mean length of service prior to presentation was 5 years. The main presenting problem was alcohol misuse (33%) followed by depression (19%). Twenty-five per cent were referred for psychotherapy and 68% returned to full employment after treatment. CLINICAL IMPLICATIONS Patient characteristics of those treated at a DCMH differ from those in the wider military. An out-patient occupational mental health service returns a substantial number of patients to occupational fitness within the Armed Forces.
Pathogenesis of cerebral aneurysms: evidence using experimentally induced cerebral aneurysm models

Background: Cerebral saccular aneurysm is a major cause of subarachnoid hemorrhage, one of the cerebrovascular diseases with the highest mortality. The mechanisms underlying the development of aneurysm, however, still remain unclear. Objective: The authors have made a series of reports on an animal model of experimentally induced cerebral aneurysms that resemble human cerebral aneurysms in their location and morphology. The objective of this brief review is to introduce our evidence about the pathogenesis of cerebral aneurysms using the experimentally induced cerebral aneurysm model, particularly focused upon the role of nitric oxide (NO) and shear stress on degenerative changes of the arterial wall during aneurysm development. Methods: We first introduce methods of aneurysm-inducing surgery, and then refer to morphological analysis of aneurysmal induction. Next, we explain the association between aneurysmal development and shear stress and NO. Finally, we show several mechanisms of aneurysmal development using genetically modified animals. Results and conclusion: In our animal model, cerebral aneurysms are induced in rats, monkeys, and mice by ligation of the unilateral common carotid artery and renal hypertension, suggesting that an increase in hemodynamic stress is a key requirement for the aneurysm development. Our morphological and molecular studies suggest that increased wall shear stress, iNOS-derived NO, MMP-2 & 9, cathepsin B, NF-κB, interleukin-1β, and endothelin B receptor are associated with the progression of cerebral aneurysms. Statin and Nifedipine may be possible drugs for the prevention of cerebral aneurysm development.
Progress of tumor marker research in Nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a prevalent tumour in southernChina and southeast Asia, particularly in the Cantonese population, where its incidence has remained high for decades.This cancer is an Epstein-Barr virus-associated malignancy with a remarkable racial and geographical distribution. It is highly prevalent in southern Asia where the disease occurs at a prevalence about a 100-fold higher compared with other populations not at risk. We still see patients recur after primary treatment with radiotherapy or chemo-irradiation. Management of nasopharyngeal carcinoma remains one of the biggest clinical challenges. There have been break throughs in early detection, diagnosis, multi-modality treatment and also disease monitoring for NPC. Systemic treatment has been crucial to the management of locally advanced or metastatic NPC. With the advent of molecular targeted therapy and personalized medicine, novel therapies based on molecular targets of NPC have become the focus of research and development over the last decade，The etiology of NPC is thought to be associated with a complex interaction of genetic, viral,environmental and dietary factors.Thanks to the advancements in genomics, proteomics and bioinformatics in recent decades, more understanding of the disease etiology,carcinogenesis and progression has been gained. Research into these components may unravel the pathways in NPC development and potentially decipher the molecular characteristics of the malignancy in recent years, the attention to the study of tumor markers associated with the NPC, this paper summarizes the research progress of the NPC in recent years, a variety of related research progress of tumor markers and its early diagnosis and curative effect evaluation to the NPC, treatment and prognosis of great significance.
Magic pencil: generalized sketch inversion via generative adversarial nets

Human can draw the sketches to show their imagination, which are more specific and vivid comparing with the text. The traditional work on sketch are focusing on recognition, which could be seen as the dimension reduction mapping from the sketch images to the semantic space. Different from the existing work, in this paper, we propose a novel image synthetic approach named Magic Pencil, which aims to synthesize the real images based on the sketch. Specifically, we design a novel multi-task neural network based on generative adversarial nets composed of three components i.e. the generator, the discriminator, and the classifiers. The generator is used to generate the real images after we input the sketch image and the variational factors. While the discriminator is designed to judge the reality of the generated images. And the classifiers is created to validate the semantic consistency between the sketch input and the generated images. We show that our proposed multi-task neural network trained end-to-end achieves promised results without further processing. To train our proposed neural network, we collect a novel dataset based on the existing sketchy dataset. From the experimental results, we could observe that our method could generate the semantic consistency and nearly reality images.
The Interplay of Reflective and Experimental Spaces in Interrupting and Reorienting Routine Dynamics

When organization members strive to radically change routines, they face a puzzle: How can they bring about change in performances when these are guided by pre-existing ideas on how to perform the routine, that are themselves recursively reproduced? Drawing on insights from longitudinal case studies of two initiatives to change patient processes in hospitals, this paper suggests that two types of “spaces”—bounded social settings characterized by social, physical, temporal, and symbolic boundaries—are important mechanisms through which actors engage in deliberate efforts to alter both performances (performative aspect) and abstract understandings (ostensive aspect) of a given routine. Specifically, whereas reflective spaces are set apart by social, physical, and temporal boundaries and involve interactions that are geared toward developing novel conceptualizations of a routine, experimental spaces enable the integration of new actions into routine performances by locating them within the original routine, while establishing symbolic and temporal boundaries that signal the provisional and localized nature of experimental performances. As both types of spaces contribute to achieving change in complementary ways, they need to be enacted iteratively in relation to each other. The study offers a model of intentional routine change that articulates the role of spaces in interrupting and reorienting their recursive dynamics.
Advanced Ovarian Cancer: Primary or Interval Debulking? Five Categories of Patients in View of the Results of Randomized Trials and Tumor Biology: Primary Debulking Surgery and Interval Debulking Surgery for Advanced Ovarian Cancer.

BACKGROUND Standard treatment of stage III and IV advanced ovarian cancer (AOC) consists of primary debulking surgery (PDS) followed by chemotherapy. Since the publication of the European Organisation for Research and Treatment of Cancer/National Cancer Institute of Canada trial, clinical practice has changed and many AOC patients are now treated with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). The best option remains unclear. Ovarian cancer is a heterogenic disease. Should we use the diversity in biology of the tumor and patterns of tumor localization to better stratify patients between both approaches? METHODS This analysis was based on results of five phase III randomized controlled trials on PDS and IDS in AOC patients, three Cochrane reviews, and four meta-analyses. RESULTS There is still no evidence that NACT-IDS is superior to PDS. Clinical status, tumor biology, and chemosensitivity should be taken into account to individualize surgical approach. Nonserous (type 1) tumors with favorable prognosis are less chemosensitive, and omitting optimal PDS will lead to less favorable outcome. For patients with advanced serous ovarian cancer (type 2) associated with severe comorbidity or low performance status, NACT-IDS is the preferred option. CONCLUSION We propose stratifying AOC patients into five categories according to patterns of tumor spread (reflecting the biologic behavior), response to chemotherapy, and prognosis to make a more rational decision between PDS and NACT-IDS. IMPLICATIONS FOR PRACTICE Trial results regarding effect and timing of debulking surgery on survival of patients with advanced ovarian cancer have been inconsistent and hence difficult to interpret. This review examines all randomized trials on primary and interval debulking surgery in advanced ovarian cancer, including the results of the newly published CHORUS (chemotherapy or upfront surgery for newly diagnosed advanced ovarian cancer) trial. On the basis of findings presented in this review and in view of recent molecular data on the heterogeneity of ovarian tumors, we propose prognostic categorization for patients with advanced ovarian cancer to better distinguish those who would optimally benefit from primary debulking from those who would better benefit from interval debulking following neoadjuvant chemotherapy.
A transformed pregnancy: the psychosocial consequences of gestational diabetes

Gestational diabetes (i.e. diabetes diagnosed during pregnancy) has important implications for maternal and foetal well-being. This paper presents an ethnographic study of gestational diabetes, an unexpected, potentially life-threatening illness diagnosed during the second half of pregnancy. While previous research has conceptualised gestational diabetes as producing few consequences since it commonly disappears after delivery, this study explores the meaning women attach to the disorder. It found that gestational diabetes had a profound effect on the respondents, resulting in fear, depression and anxiety. The respondents' imagery of diabetes as a debilitating disease concomitant with blindness, amputations, and premature death generated increased anxiety throughout pregnancy and six-weeks postpartum. The personal disruption in complying with the diabetic regimen as well as health care provider transactions exaggerated the unique stress of a ‘normal’ pregnancy. We suggest that a strictly medical view of gestational diabetes minimises its broader psychosocial significance and recommend effective provider-patient interactions with ‘high-risk’ pregnant women.
HoNOS: a cautionary tale of their use in a rehabilitation service

Aims and method Health of the Nation Outcome Scales (HoNOS) were piloted in 248 patients with serious persistent mental health problems. Staff were trained by a cascade approach and rated patient outcome after six months. Results There was poor interrater reliability between nurses and psychiatrists/psychologists. Outcome measured by HoNOS often contrasted with clinical experience. Clinical implications HoNOS were not a reliable or valid measure of outcome. The scales are now completed only under supervision.
A large scale dataset for classification of vehicles in urban traffic scenes

Vehicle Classification has been a well-researched topic in the recent past. However, advances in the field have not been corroborated with deployment in Intelligent Traffic Management, due to non-availability of surveillance quality visual data of vehicles in urban traffic junctions. In this paper, we present a dataset aimed at exploring Vehicle Classification and related problems in dense, urban traffic scenarios. We present our on-going effort of collecting a large scale, surveillance quality, dataset of vehicles seen mostly on Indian roads. The dataset is an extensive collection of vehicles under different poses, scales and illumination conditions in addition to a smaller set of Near Infrared spectrum images for night time and low light traffic surveillance. We will make the dataset available for further research in this area. We propose and evaluate few baseline algorithms for the task of vehicle classification on this dataset. We also discuss challenges and potential applications of the data.