Miracle-dz/UniFAR-FTUs huggingface dataset:
Craniosynostosis. Diagnosis, evaluation and management.

Craniosynostosis. Diagnosis, evaluation and management. 2nd edition. Editors M Michael Cohen Jr, Ruth E MacLean. Oxford: Oxford University Press, 2000. In 1986, Dr Cohen published the first edition of this book on craniosynostosis. As correctly identified by Dr Gorlin in the foreword to that volume, it proved to be a “truly signal text”, so much so that, though inevitably dated by the passage of time, the first edition is still cited regularly as an essential reference in relation to craniosynostosis. In addition to providing a comprehensive approach to all aspects of diagnosis and management of craniosynostosis, the first edition reviewed the basis for clinical delineation between syndromes of craniosynostosis, bringing a degree of order to a somewhat chaotic body of publications. However, the passage of time, with the emergence of new clinical reports, …
INTEGRATIVE POULTRY BIOLOGY : CURRENT APPROACHES AND PROSPECTS FOR FRANCE-TAIWAN COLLABORATION

Few results are yet available for integrative biology in chickens. The purpose of this paper is to present some of the studies done in the France-Taiwan collaborative programmes in the framework of integrating data on population history, DNA polymorphisms and performance. The first programme involves the characterization of genetic diversity of chicken breeds using molecular markers, the second programme focuses on the molecular study of a feather colour gene in connection with variability of plumage colour, and the third programme deals with the study of genotype x environment interactions on egg production. Then the general properties of network analysis are briefly described in order to open the discussion towards the potential usefulness of this approach for animal breeding.
The experience of being a female carrier of haemophilia and the mother of a haemophilic child

Limited research has been conducted on how the female carrier experiences her life with a haemophilic child, and earlier studies are mostly questionnaire‐based. No previous qualitative study on the female carrier's situation has been conducted in Sweden. The aim of the study was to describe the lived experience of being a carrier of severe or moderate haemophilia and of being the mother of a haemophilic child. The study was conducted via qualitative interviews and analysed by means of a phenomenological hermeneutic method; a total of 13 haemophilia carriers were interviewed in 2010. Being a carrier of haemophilia and having a haemophilic child was life changing. The women moved from a state of sad, guilty chaos to reconciling themselves with the new situation. Our analysis revealed three acts in which phenomena appeared: the time after diagnosis, the turning point and reconciliation with a changing life. Emerging as crucial to the process of reconciliation with a changing life was a sense of being fully informed and supported. The Haemophilia Treatment Centre (HTC) should create an environment that encourages learning, and the team should invite and encourage the woman's partner to be actively involved in the child's care. Moreover, the results indicate that it would be beneficial to invite female carriers to receive patient education at the HTC before they plan to start a family. During this visit, the woman may gain a greater understanding of her carriership to prepare her for future decisions concerning prenatal diagnosis, for example.
ASSESSMENT OF MICROALBUMINURIA IN ESSENTIAL HYPERTENSIVES AND ITS RESPONSE TO ANGIOTENSIN-CONVERTING ENZYME INHIBITOR THERAPY

ABSTRACT Objective: Objective is to study the prevalence of microalbuminuria among patients suffering from essential hypertension and also to evaluate the response of microalbuminuria to angiotensin-converting enzyme (ACE) inhibitors therapy. Methods: The study conducted at Santosh Medical College and Hospital, Ghaziabad, on 300 patients with essential hypertension. After attaining baseline parameters in all patients, those newly diagnosed essential hypertensives with microalbuminuria not on any treatment were started on an ACE inhibitor (ramipril), for 8 weeks, after which all parameters were reassessed and comparison and statistical analysis were done to establish the prevalence of microalbuminuria and its response to therapy. Results: In our study, mean microalbuminuria excretion was 101.79 mcg/mg creatinine at the beginning of the study and 80.20 mcg/mg creatinine after 8 weeks of ACE inhibitor therapy, with 21.2% fall rate. Conclusion: Microalbuminuria is an independent risk factor for the development or worsening of hypertensive nephropathy and endothelial dysfunction, thereby increasing the risk of micro- and macro-vascular complications. Keywords : Microalbuminuria, Essential hypertension, Angiotensin-converting enzyme inhibitor therapy.
Implement Topic Relevance Model For Query Expansion

Query expansion is one of most important technique in information retrieval where provides a series of methods to reform the query applying to retrieval in order to extract result more precisely. In the past, there are many kind of trails on this technique in different perspective. In this project, I’ll try to implement query expansion with topic models, where using topic modeling technique to help us to do query expansion. In this project, I implement the Relevance Model (RM) approach by topic model LDA, and compare the retrieval result with baseline and naive query expansion result.
Identification of Specific Nucleotide Sequences within the Conserved 3′-SL in the Dengue Type 2 Virus Genome Required for Replication

ABSTRACT The flavivirus genome is a positive-stranded ∼11-kb RNA including 5′ and 3′ noncoding regions (NCR) of approximately 100 and 400 to 600 nucleotides (nt), respectively. The 3′ NCR contains adjacent, thermodynamically stable, conserved short and long stem-and-loop structures (the 3′-SL), formed by the 3′-terminal ∼100 nt. The nucleotide sequences within the 3′-SL are not well conserved among species. We examined the requirement for the 3′-SL in the context of dengue virus type 2 (DEN2) replication by mutagenesis of an infectious cDNA copy of a DEN2 genome. Genomic full-length RNA was transcribed in vitro and used to transfect monkey kidney cells. A substitution mutation, in which the 3′-terminal 93 nt constituting the wild-type (wt) DEN2 3′-SL sequence were replaced by the 96-nt sequence of the West Nile virus (WN) 3′-SL, was sublethal for virus replication. An analysis of the growth phenotypes of additional mutant viruses derived from RNAs containing DEN2-WN chimeric 3′-SL structures suggested that the wt DEN2 nucleotide sequence forming the bottom half of the long stem and loop in the 3′-SL was required for viability. One 7-bp substitution mutation in this domain resulted in a mutant virus that grew well in monkey kidney cells but was severely restricted in cultured mosquito cells. In contrast, transpositions of and/or substitutions in the wt DEN2 nucleotide sequence in the top half of the long stem and in the short stem and loop were relatively well tolerated, provided the stem-loop secondary structure was conserved.
Experimental allergic encephalomyelitis as a guide to the understanding and treatment of multiple sclerosis

2. Koeppen AH, Denringer MP. Brain hemosiderin and superficial siderosis of the central nervous system. J Neuropathol Exp Neurol 1988;47:249-270 3. Koeppen AH, Borke RC. Experimental superficial siderosis of the central nervous system I. Morphological observations. J Neuroparhol Exp Neurol 1991;50:579-534 4. Koeppen AH, Hurwitt CG, Dearborn RE, et al. Experimental superficial siderosis of the central nervous system: biochemical correlates. J Neurol Sci 1992;112:38-45 5 . Koeppen AH, Dickson AC, Chu RC, Thach RE. The pathogenesis of superficial siderosis of the central nervous system. Ann Neurol 1993;34:646-653 227-236
Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders

Objectives Autism (MIM♯209850) and schizophrenia (MIM♯181500) are both neurodevelopmental psychiatric disorders characterized by a highly genetic component. Homeogenes and forkhead genes encode transcription factors, which have been involved in brain development and cell differentiation. Thus, they are relevant candidate genes for psychiatric disorders. Genetic studies have reported an association between autism and DLX2, HOXA1, EN2, ARX, and FOXP2 genes whereas only three studies of EN2, OTX2, and FOXP2 were performed on schizophrenia. Interestingly, most of these candidate genes contain trinucleotide repeats coding for polyamino acid stretch in which instability can be the cause of neurodevelopmental disorders. Our goal was to identify variations of coding trinucleotide repeats in schizophrenia, autism, and idiopathic mental retardation. Methods We screened the coding trinucleotide repeats of OTX1, EN1, DLX2, HOXA1, and FOXP2 genes in populations suffering from schizophrenia (247 patients), autism (98 patients), and idiopathic mental retardation (56 patients), and compared them with control populations (112 super controls and 202 healthy controls). Results Novel deletions and insertions of coding trinucleotide repeats were found in the DLX2, HOXA1, and FOXP2 genes. Most of these variations were detected in controls and no difference in their distribution was observed between patient and control groups. Two different polymorphisms in FOXP2 were, however, found only in autistic patients and the functional consequences of these variations of repeats have to be characterized and correlated to particular clinical features. Conclusion This study did not identify specific disease risk variants of trinucleotide repeats in OTX1, EN1, DLX2, HOXA1, and FOXP2 candidate genes in neurodevelopmental psychiatric disorders.
An Exploratory Probe into the WTO and the Innovation of China's Higher Education——A Case Study on Nottingham Ningbo Campus

Since the successful accession to the WTO,China has accelerated its process of internationalization and meanwhile,the demand of China's human resource market for the new-type internationalized talents has risen sharply as well.The University of Nottingham,Ningbo,China,whose mission is to cultivate the first-class international talents,to much extent,can meet the demands.Its unique student-centered teaching concept and the new teaching organization focusing on fostering students' self-learning and research ability and critic thinking ability are just like the fresh blood injected into the Chinese Higher Education System.This paper mainly analyses the teaching mode of the University of Nottingham,Ningbo,China,in order to give some reflection on the relationship between the WTO and the innovation in the higher education in our country.
Brain aging and late-onset Alzheimer's disease: many open questions

ABSTRACT Despite decades of research in the field of Alzheimer's disease (AD), a real understanding of its molecular pathophysiology and treatments relevant to the day-to-day lives of patients remain out of reach. Research has, with good reason, focused on certain key pathways and potential mechanisms, but sometimes this has been at the expense of work on other theories, which may be slowing down progress in this field. Interesting theories at present include oxidative stress and caloric restriction. Work on the Aβ cascade should continue but with a shift in focus to its intracellular effects and an awareness that additional pathogenetic factors and processes must be involved – most importantly, brain aging. Hyperphosphorylation of tau, for instance, provides another interesting pathway, with one old drug showing promise in this regard. Moreover, work in epigenetics and on protein homeostasis has produced interesting findings and both lines of investigation may reveal suitable targets for future intervention. Taken together, analysis of the biochemistry of aged neurons and the interplay with pathways of neurodegeneration may lead to a better understanding of AD and how to treat and prevent this condition.
Demonstration of mechanical and physiological variables in professional football matches

The main objective of this study was to show the data obtained through a system of controlling the load-based GPS technology, for mechanical and physiological variables analyzed, obtained during the friendly games made by a professional 1st division Spanish football team during the 2007-08 season. The second objective in this study was to show the differences in these variables analyzed by the positions of the field players. They have been monitored 21 field professional players (28 ± 3.8 years old, 179 ± 4.5 cm, 75.2 ± 4.2 kg; VT2 Speed: 13.8 ± 0.6 km / h, HR at VT2 : 174 ± 10.8 p / m; aerobic Top speed: 18.6 ± 1 mph, HR Maximum: 192 ± 8.1 p / m) of the first team of a professional football club from the Spanish 1 Division League (season 2007-08). We have used 10 Spi Elite units with GPS receiver, triaxial accelerometer and integrated HR chip receiver (GPSports Systems Pty. Ltd., 2003, Australia). Based on the results we concluded that: A) It is very useful the use of technologies that allow us to comprehensively monitor the player. B) The variables used are an important aid to control the conditional player performance during a game and in the individualization of the training process. C) It is important to have individualized references data obtained during games to control each player training. Introduction. Several studies have provided data on physical and physiological demands of football matches (Withers et al., 1982; Ekblom, 1986; Bangsbo et al., 1991; Reilly, 1996; Ohashi et al., 2002; Di Salvo et al. 2006; Zubillaga, A. 2006), using different technologies increasingly advanced and accurate. It is not until very recently that we have global (GPS) and local (LPS) positioning systems sufficiently precise, with specific software for analysis, so that the analysis of these requirements is much more comprehensive and adjusted. In order to have a starting point in addressing collective and individual demands of the competition on the professional football player, as well as control of training loads, we have been using for two seasons 10 control units Spi Elite (GPSports, Australia)-based GPS technology with embedded HR control, as well as triaxial accelerometer. This systematic use both in training and in all friendly games made, has enabled us to collect individualized information from each monitored player, allowing us to observe and monitor how each player performs with the demands made by these games and training sessions,
Parent and Child ADHD Symptoms in Relation to Parental Attitudes and Parenting: Testing the Similarity-Fit Hypothesis

Objective: We tested the similarity-fit hypothesis that predicts more positive parenting when both parent and child have high levels of ADHD symptoms compared to when only one does. Method: Mothers and fathers of 156, 5 to 13 year old sons participated (110 boys with ADHD, 46 without). Parent inattentive and hyperactive-impulsive symptoms were examined, in interaction with child ADHD, as predictors of parental tolerance, empathy, encouragement of child autonomy, and positive parenting. Results: Several interactions of parent ADHD symptoms and child ADHD were detected which suggested that for parents with low levels of symptoms, the presence of child ADHD was associated with less positive parenting attitudes and behavior, but this negative relation between positive parenting and child ADHD was dampened among parents with more ADHD symptoms. Conclusions: Considered alongside the well documented parenting difficulties associated with parental ADHD, our findings suggest that parental ADHD symptoms also may help to mitigate some of the challenges facing families of children with ADHD.
A "NEW" ANTIGEN IN LEUKEMIA SERA.

Patients who receive large numbers of transfusions for anemia and other causes may develop precipitins in their blood. These precipitins may react in agar gel double diffusion experiments with specific human serum lipoprotein found in the blood of other individuals. Since these precipitins were found only in patients who had received transfusions they were thought to be antibodies against serum lipoproteins which developed in the patients as a result of the repeated transfusions. The precipitin is referred to as an isoprecipitin since it develops against a specificity found in an individual from the same species. The antilipoprotein isoprecipitin1,2developed in approximately 30% of 47 patients with thalassemia who had received transfusions. Isoprecipitins also developed in smaller number of transfused patients with other diseases. All precipitins stained with sudan black, a dye specific for lipid. Immunoelectrophoretic and ultracentrifugal studies showed that the protein with which the isoprecipitins reacted was a
Tension-Compression Fatigue Behavior of Plain Woven Kenaf/Kevlar Hybrid Composites

The applications of hybrid natural/synthetic reinforced polymer composites have been rapidly gaining market share in structural applications due to their remarkable characteristics and the fact that most of the components made of these materials are subjected to cyclic loading. Their fatigue properties have received a lot of attention because predicting their behavior is a challenge due to the effects of the synergies between the fibers. The purpose of this work is to characterize the tension, compression, and tensile-compression fatigue behavior of six layers of Kevlar hybridized with one layer of woven kenaf reinforced epoxy, at a 35% weight fraction. Fatigue tests were carried out and loaded cyclically at 60%, 70%, 80%, and 90% of their ultimate compressive stress. The results give a complete description for tensile and compression properties and could be used to predict fatigue-induced failure mechanisms.
Lateral gene transfer and metabolic adaptation in the human parasite Trichomonas vaginalis.

*Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada; †Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada; ‡Genome Sequence Centre, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada; and §Canadian Institute for Advanced Research, Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada
Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)

The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. Not only the stability of dosage forms and their release rate are affected but also their circulation in the blood stream and absorption into body membranes are dramatically altered by ZP. In this paper the effect of ZP on the various properties of nano-medicines are reviewed. Furthermore, the ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed.
Toward a Model of Emotion Influences on Agile Decision Making

This position paper describes an approach to create a framework for modeling affect in decision making for agile processes, and a procedure to test its use by applying it to the introduction of Multi Criteria Decision Methods, and in particular the Best Worst Method, into agile development. We believe that affect changes development in a significant way especially for agile development, which requires close collaboration. We postulate that the structuring of a decision will engage a larger audience eliciting full participation by actors like the customer who are not necessarily accustomed to a development environment. Further, we believe that the structuring of the decision process and the involvement of a larger pool of actors will reduce negative affect, thus enabling a faster, better empowering set of decisions that ultimately will result in higher quality software products and a lower development time.
Ondansetron and irritable bowel syndrome

We read the paper by Garsed et al, 1 which revives interest in 5-hydroxytryptamine (5-HT) receptor antagonists as treatment for diarrhoea-predominant irritable bowel syndrome (IBS-D). As a highly prevalent functional gastrointestinal (GI) disorder,2 without a known organic pathology to target, IBS continues to be challenging to treat. Interest in agents acting on 5-HT receptors selectively is not novel, with alosetron, the most well-studied 5-HT3 antagonist, demonstrating efficacy in treating IBS-D.3 However, cases of severe constipation and ischaemic colitis led to the withdrawal of the drug. Ondansetron first demonstrated effects on GI transit over …
Neutrophil CD64 as a Diagnostic Marker of Sepsis in Neonates

Background Sepsis in neonates hospitalized in the neonatal intensive care unit is a global problem and is a significant contributor to morbidity and mortality. Neutrophil surface CD64, the high-affinity Fc receptor, is quantitatively up-regulated during infection and sepsis. Objective Our goal in this prospective study was to measure the neutrophil CD64 in blood as an adjunct to our previously validated hematologic scoring system for detecting neonatal sepsis. Methods A prospective study enrolled newborns with documented sepsis (n = 25), clinical sepsis (n = 25), and control newborns (n = 25). C-reactive protein, neutrophil CD64, complete blood counts, and blood cultures were taken. Neutrophil CD64 was analyzed by flow cytometry. Results CD64 was significantly elevated in the groups with documented and clinical sepsis (P < 0.001). CD64 had a sensitivity of 96%, a specificity of 100%, a positive predictive value of 96.2%, and a negative predictive value of 100% with a cutoff value of 45.8% and 46.0% in the confirmed and the clinical sepsis groups, respectively. Conclusions CD64 expression on neutrophils increases significantly in neonates with sepsis and can be considered a useful diagnostic marker for early diagnosis of neonatal infection as a single determination compared with other inflammatory markers.
Laterality and deep brain stimulation of the subthalamic nucleus: applying a dichotic listening task to patients treated for Parkinson’s disease

Ear advantage during a dichotic listening task tends to mirror speech lateralization. Previous studies in stroke patients have shown that lesions in the dominant hemisphere often seem to produce changes in ear advantage. In this study six Parkinson’s disease (PD) patients treated for motor symptoms with deep brain stimulation (DBS) of the left subthalamic nucleus (STN) were tested preoperatively and at approximately 6 and 18 months postoperatively with a dichotic listening task. Results show a significant decline of the right ear advantage over time. In three of the patients a right ear advantage preoperativley changed to a left ear advantage 18 months postoperatively. This suggests the possibility that additional longitudinal studies of this phenomenon could serve as a model for understanding changes in indirect measures of speech lateralization in stroke patients.
p53 protein expression does not correlate with EBV status in childhood B non‐hodgkin lymphomas

The p53 tumor suppressor gene is affected in a wide range of human cancers, including hematological malignancies. This gene encodes a nuclear phosphoprotein p53, which plays a key role in cell cycle arrest, induction of apoptosis, and DNA repair. Mutations of the p53 gene often lead to the accumulation of the mutated protein in the nucleus of neoplastic cells. However, p53 protein expression is frequently detected in non‐Hodgkin lymphomas (NHL) without any correlation with p53 mutations. This discordance suggests the existence of other mechanisms to stabilize the p53 protein, including binding of p53 protein to viral proteins. p53 protein has been shown to bind to proteins encoded by the Epstein‐Barr virus (EBV).