Miracle-dz/UniFAR-FTUs huggingface dataset:
Genital Tract HIV RNA Levels and Their Associations With Human Papillomavirus Infection and Risk of Cervical Precancer

Objective:Plasma HIV RNA levels have been associated with the risk of human papillomavirus (HPV) and cervical neoplasia in HIV-seropositive women. However, little is known regarding local genital tract HIV RNA levels and their relation with cervical HPV and neoplasia. Design/Methods:In an HIV-seropositive women's cohort with semiannual follow-up, we conducted a nested case–control study of genital tract HIV RNA levels and their relation with incident high-grade squamous intraepithelial lesions (HSIL) subclassified as severe (severe HSIL), as provided for under the Bethesda 2001 classification system. Specifically, 66 incidents of severe HSIL were matched to 130 controls by age, CD4+ count, highly active antiretroviral therapy use, and other factors. We also studied HPV prevalence, incident detection, and persistence in a random sample of 250 subjects. Results:Risk of severe HSIL was associated with genital tract HIV RNA levels (odds ratio comparing HIV RNA ≥ the median among women with detectable levels versus undetectable, 2.96; 95% confidence interval: 0.99 to 8.84; Ptrend = 0.03). However, this association became nonsignificant (Ptrend = 0.51) after adjustment for plasma HIV RNA levels. There was also no association between genital tract HIV RNA levels and the prevalence of any HPV or oncogenic HPV. However, the incident detection of any HPV (Ptrend = 0.02) and persistence of oncogenic HPV (Ptrend = 0.04) were associated with genital tract HIV RNA levels, after controlling plasma HIV RNA levels. Conclusions:These prospective data suggest that genital tract HIV RNA levels are not a significant independent risk factor for cervical precancer in HIV-seropositive women, but they leave open the possibility that they may modestly influence HPV infection, an early stage of cervical tumorigenesis.
Surface micromachined multi-layer moving gate field effect transistor (MOGFET) pressure switch with integrated vacuum sealed cavity

A microelectromechanical pressure switch with electronic switching using a moving gate field effect transistor (MOGFET) has been designed and fabricated. The MOGFET is designed to replace the metal to metal contact switches which are susceptible to arcing, micro-welding, and deformation of the contacts. Sufficient pressure hysteresis is achieved by the electrostatic force between the moving gate and the substrate. The threshold pressures and the pressure hysteresis are adjustable electrically. The spring-capacitor model is presented to explain pull-in and pull-out conditions which are critical for stable switching operations. A vacuum cavity is formed during fabrication process and provides the reference vacuum pressure without an extra vacuum package. The fabricated devices have various switching pressure ranges from 12 psia to 500 psia. The measured switching channel resistance values are approximately 11.8 K/spl Omega/ for a channel W/L ratio of 21 and 2.4 K/spl Omega/ for a W/L ratio of 51 at the gate voltage of 12 V.
Reconstrucción de caracteres para mejora de sistemas OCR con RNA's

Resumen. Numerosos avances dentro de la Inteligencia Artificial han estado inspirados en las caracteŕisticas de los procesos biologicos de las redes neuronales. Estas caracteŕisticas, por las ventajas que presentan, han intentado ser emuladas dentro de una computadora para imitar las tareas que son capaces de realizar los seres humanos. Siendo el OCR (Optical Character Recognition) una habilidad humana, la intencion de utilizar RNAs (Redes Neuronales Artificiales) para un sistema de reconocimiento de caracteres, va en relacion de como las RNAs tratan de simular los procesos que ocurren en el cerebro humano. El presente trabajo implementa un sistema OCR mediante RNAs, aśi como una modificacion al mismo, implementando un paradigma para la reconstruccin del patron de entrada (con una red Hopfield) antepuesto al paradigma utilizado para el reconocimiento (red Perceptron). Las pruebas realizadas comparan los resultados entre el sistema OCR original y el modificado para este trabajo, utilizando tanto numeros como letras. Las ventajas de la modificacion planteada para este trabajo pueden ser ampliadas a cualquier sistema OCR ya implementado sin importar el metodo de reconocimiento utilizado. Los resultados muestran una importante mejora en el porcentaje de reconocimiento con el metodo propuesto respecto al metodo comparado.
Lactoferrin decreases primary bovine mammary epithelial cell viability and casein expression

The concentration of lactoferrin (LTF) in milk varies during lactation, rising sharply during involution. We proposed that LTF might have a regulatory role in involution and investigated its effects in vitro on the viability of bovine mammary epithelial cells (BMEC) and on casein expression in bovine mammospheres. Mammospheres capable of milk protein expression were formed by culturing primary BMEC on extracellular matrix in the presence of lactogenic hormones. Exogenously added LTF decreased β-casein and κ-casein mRNA expression in mammospheres while transfection of a short interfering RNA (siRNA) to suppress LTF expression resulted in increased casein mRNA expression. We believe that LTF exerts its effect on casein gene expression by up-regulating interleukin-1β (IL-1β) as IL-Iβ gene expression was elevated in mammospheres treated with LTF. LTF also decreased viability of BMEC grown as monolayers and as mammospheres. Interestingly, LTF was only effective in reducing casein mRNA expression and viability in mammospheres when added at concentrations found during early involution but was inactive when used at concentrations found in milk. We suggest that LTF has a regulatory role during early involution, decreasing casein expression and reducing BMEC viability.
Anorexia nervosa and ‘Turner syndrome’: cause or coincidence?

SYNOPSIS We report the eleventh documented case of the concurrence of anorexia nervosa and ‘Turner syndrome’. Although some authors have suggested that the 2 syndromes occur together more often than by chance, and 5% of anorexia nervosa patients karyotyped to date have ‘Turner syndrome’, recent evidence in fact suggests that the 2 conditions do not occur together more often than one would expect by chance.
Gestión del conocimiento y gestión de recursos humanos: una convergencia necesaria Knowledge management and human resource management: a necessary convergence

The aim of this paper is to examine the necessary convergence between knowledge management and strategic human resource management. The resource-based view of the firm is used, along with other theoretical sources, to outline the basic elements of an integration between knowledge management and strategic human resource management. Concepts of Revista de Psicología del Trabajo y de las Organizaciones 2002 Volumen 18, n.o 2-3 Págs. 177-213 * Facultad de Economía y Empresa, Departamento de Psicología Social y Antropología, Campus Miguel de Unamuno (Edificio FES), 37007, Salamanca (España). Gestión del conocimiento y gestión de recursos humanos: una convergencia necesaria 1 7 8 REVISTA DE PSICOLOGÍA DEL TRABAJO Y DE LAS ORGANIZACIONES knowledge, human capital, and human resource system are discussed as strategic assets likely to become a source of sustainable competitive advantage for the company. These elements have characteristics of strategic resources: the are uncommon, valuable, inimitable and irreplaceable. the proposed conceptualization is used to examine how the process dynamics can provide a sustainable competitive advantage. This paper also discusses some of the implications of convergence between knowledge management and strategic human resource management within the framework of the resource-based theory of competitive advantage.
Inducing Event Types and Roles in Reverse: Using Function to Discover Theme

With growing interest in automated event extraction, there is an increasing need to overcome the labor costs of hand-written event templates, entity lists, and annotated corpora. In the last few years, more inductive approaches have emerged, seeking to discover unknown event types and roles in raw text. The main recent efforts use probabilistic generative models, as in topic modeling, which are formally concise but do not always yield stable or easily interpretable results. We argue that event schema induction can benefit from greater structure in the process and in linguistic features that distinguish words’ functions and themes. To maximize our use of limited data, we reverse the typical schema induction steps and introduce new similarity measures, building an intuitive process for inducing the structure of unknown events.
Work Experience from Paid Employment and the Path to Entrepreneurship: Business Takeover Versus New Venture Start-Up

Our paper investigates how the type of work experience gained from prior paid employment influences the path to entrepreneurship. We distinguish between two distinct entrepreneurship entry modes: business takeover and new venture start-up. Using a large and rich French data set, we find that small firm experience increases the likelihood for business takeover, whereas management and same sector experience both increase the likelihood for new ventures. Our findings are relevant for policymakers aiming to improve the business transfer process.
Arabidopsis AUX1 Gene: A Permease-Like Regulator of Root Gravitropism

The plant hormone auxin regulates various developmental processes including root formation, vascular development, and gravitropism. Mutations within the AUX1 gene confer an auxin-resistant root growth phenotype and abolish root gravitropic curvature. Polypeptide sequence similarity to amino acid permeases suggests that AUX1 mediates the transport of an amino acid-like signaling molecule. Indole-3-acetic acid, the major form of auxin in higher plants, is structurally similar to tryptophan and is a likely substrate for the AUX1 gene product. The cloned AUX1 gene can restore the auxin-responsiveness of transgenic aux1 roots. Spatially, AUX1 is expressed in root apical tissues that regulate root gravitropic curvature.
A competitive model for apartment complexes energy management with the aim of creating the infrastructure of smart city

This paper presents a competitive model for energy managment at the residential complexes in a city.This model includes cultural patterns and technical models together.The combination of culture and technology is improved energy managment at consumers side and decreased problems at utility side for energy supply. The consumer owned smart meter shared data with a control and monitoring center(CMC) through wire or wireless platform and on the other side, a data analyst application is enabled on the server and after analyzing and processing data received from the customers, the information are transmitted to a database(SQLite). A web application also uses the information stored in the database. The smart meters integrate different types of information coming from several electric or electronic devices present in buildings via ZigBee or WiFi platform.This information are shown to the building residents through graphical forms, tables and charts via web programming methods.
Why do companies go public? Evidence from nairobi stock exchange

The study sought to find out the reasons that drive firms to go public. The study analysed fifteen companies which went public between 1990 and 2008. Exploratory survey was used as it enabled the researcher to obtain information from broad category of firms. The study used structured questionnaires to obtain the necessary information. The data was analysed using Microsoft Excel and the Statistical package for social sciences (SPSS) which were utilized to perform the various statistical analysis. The findings showed that the major reasons why companies go public are the capital raising aspects and the implementation by the government of its divestiture policy. The main problems encountered are the high listing cost and the stringent market regulations by the Capital market authority (CMA) and the Nairobi stock exchange (NSE) who are the main players. Minimization o f cost of capital and broadening the ownership base of the companies were cited as the main motivating factor for conducting an Initial public offering. In conclusion, companies either private or public corporations should go public so as to tap the vibrant market and enjoy the benefits that come with being public.
MIrfLCSIR-5 16 PROTEUS : A HIGH-PERFORMANCE PARALLEL-ARCHITECTURE SIMULATOR

PROTEUS is a high-performance simulator for MIMD multiprocessors. It is fast, accurate, and flexible: it is one to two orders of magnitude faster than comparable simulators, it can reproduceresults from real multiprocessors, and it is easily configured to simulate a wide range of architectures. PROTEUS provides a modular structure that simplifies customization and independent replacement of parts of architecture. There are typically multiple implementations of each module that provide different combinations of accuracy and performance; users pay for accuracy only when and where they need it. Finally, PROTEUS provides repeatability, nonintrusive monitoring and-debugging, and integrated graphical output, which result in a development environment superior to those available on real multiprocessors.
Two communication lines in a 3 × 3 matrix speller

In a matrix speller both eye fixation and attention are reflected in the event-related potentials to highlighting of characters. We consider the question of whether this can be used to open up two parallel channels by dissociating the attended character from the fixated one. Complementary classifiers for both characters are established and their relationship is investigated.
Managing the Process of Electronic Communication in a Small Legal Firm

The purpose of this article is to present the issues related to the management process in the electronic communication of a small law firm. In the introduction, the role of information and knowledge in shaping the competitiveness of enterprises is presented. Then the phenomenon of electronic communication as a process of data transmission is shown, which on the one hand determines the competitive position of economic entities including law firms and legal counsellors, and on the other hand, it is the subject of legal regulations. Because the information provided by electronic means shall be subject to the professional secrecy of legal attorneys or solicitors, as the principle of confidentiality applicable to lawyers according to relevant legislation does not exempt these entities from the responsibility in terms of the protection of personal data. Another area raised in the article is to identify actions to protect information transmitted electronically. The last part of the study is to present the results of studies that show the extent to which we use e-mail, free applications such as Dropbox and Google Drive. Moreover the issues of the frequency of password changing and encryption of media as well as attacks on data owned by an office have been discussed. The whole content has been summarized with conclusions.
5 COMPETENCIES Needed by New Baccalaureate Graduates

As nurse educators prepare new graduates for practice, part of the challenge is to ensure that these nurses are capable of functioning in a broad continuum of care with increased responsibilities. To identify competencies needed by new baccalaureate graduates in today's health care environment and determine whether these competencies fall into particular dimensions, a cross-sectional survey design was used to query 363 nurse administrators from three health care settings. Nurse administrators rated the importance of 45 nursing competencies. Factor analysis was conducted on the competency items, and factor scores were calculated to determine the importance ratings by work setting groups. Findings revealed a simple six-factor competency structure (Health Promotion Competency, Supervision Competency, Interpersonal Communication Competency, Direct Care Competency, Computer Competency, and Caseload Management Competency). MANOVA indicated significant differences in the importance of these competence factors by work setting. The findings are an important beginning for evidence-based decision-making about nursing curriculum reform, both in the classroom and clinical practice areas. The study also provides a foundation for further measurement of nursing competencies.
Application of MoM-GEC Method for Electromagnetic Study of Planar Microwave Structures: Shielding Application

: In this paper, an electromagnetic analysis is presented for describing the influence of shielding in a rectangular waveguide. A hybridization based on the method of moments combined to the generalized equivalent circuit MoM-GEC is used to model the problem. This is validated by applying the MoM-GEC hybridization to investigate a diffraction structure. It consists of electromagnetic diffraction by an iris in a rectangular waveguide. Numerical results are shown and discussed and a comparison with FEM and Marcuvitz methods is achieved.
Molecular Evolution of Spider Vision: New Opportunities, Familiar Players

Spiders are among the world’s most species-rich animal lineages, and their visual systems are likewise highly diverse. These modular visual systems, composed of four pairs of image-forming “camera” eyes, have taken on a huge variety of forms, exhibiting variation in eye size, eye placement, image resolution, and field of view, as well as sensitivity to color, polarization, light levels, and motion cues. However, despite this conspicuous diversity, our understanding of the genetic underpinnings of these visual systems remains shallow. Here, we review the current literature, analyze publicly available transcriptomic data, and discuss hypotheses about the origins and development of spider eyes. Our efforts highlight that there are many new things to discover from spider eyes, and yet these opportunities are set against a backdrop of deep homology with other arthropod lineages. For example, many (but not all) of the genes that appear important for early eye development in spiders are familiar players known from the developmental networks of other model systems (e.g., Drosophila). Similarly, our analyses of opsins and related phototransduction genes suggest that spider photoreceptors employ many of the same genes and molecular mechanisms known from other arthropods, with a hypothesized ancestral spider set of four visual and four nonvisual opsins. This deep homology provides a number of useful footholds into new work on spider vision and the molecular basis of its extant variety. We therefore discuss what some of these first steps might be in the hopes of convincing others to join us in studying the vision of these fascinating creatures.
IDIOPATHIC POLYPOIDAL CHOROIDAL VASCULOPATHY (IPCV)

Eleven patients, 40 to 71 years old, had a choroidal vasculopathy that led to hemorrhagic and exudative macular degeneration. The patients had peculiar polypoidal, subretinal, vascular lesions associated with serous and hemorrhagic detachments of the retinal pigment epithelium. This macular disorder, which we have named idiopathic polypoidal choroidal vasculopathy (IPCV), appears to represent a distinct entity that differs clinically and demographically from age-related macular degeneration (AMD) and other macular diseases associated with subretinal neovascularization. Recognition of this condition is important because it may have specific risk factors, natural course, and management considerations that differ from those of age-related macular degeneration.
The observation of trapping and detrapping effects in high-k gate dielectric MOSFETs by a new gate current Random Telegraph Noise (IG-RTN) approach

A new method, called gate current random telegraph noise (IG RTN), was developed to analyze the oxide quality and reliability of high-k gate dielectric MOSFETs. First, a single electron trapping/detrapping from process induced trap in nMOSFET was observed and the associated physical mechanism was proposed. Secondly, IG RTN has also been successfully applied to differentiate the difference in electron tunneling mechanism for a device under high-field or low-field stress. Finally, the soft-breakdown (SBD) behavior of a device can be clearly identified. Its IG RTN characteristic is different from that before soft-breakdown. It was found that SBD will indeed induce extra leakage current as a result of an additional breakdown path.
Effects of chronic hypoxia on renal renin gene expression in rats.

BACKGROUND The effects of hypoxia on renin secretion and renin gene expression have been controversial. In recent studies, we have demonstrated that acute hypoxia of 6 h duration caused a marked stimulation of renin secretion and renal renin gene expression. This hypoxia-induced stimulation of the renin-angiotensin system might contribute, for example, to the progression of chronic renal failure and to the development of hypertension in the sleep-apnoea syndrome. For this reason, we were interested in the more chronic effects of hypoxia on renal renin gene expression and its possible regulation. METHODS Male rats were exposed to chronic normobaric hypoxia (10% O(2)) for 2 and 4 weeks. Additional groups of rats were treated with an endothelin ET(A) receptor antagonist, LU135252, or a NO donor, molsidomine, respectively. Systolic blood pressure and right ventricular pressures were measured. Renal renin, endothelin-1 and endothelin-3 gene expression were quantitated using RNAase protection assays. RESULTS During chronic hypoxia, haematocrit increased to 72+/-2%, and right ventricular pressure increased by a mean of 26 mmHg. Renal renin gene expression was halved during 4 weeks of chronic hypoxia. This decrease was reversed by endothelin receptor blockade (105 or 140% of baseline values after treatment for weeks 3-4 or 1-4). Furthermore, there was a trend of increasing renal endothelin-1 gene expression (to 173% of baseline values) after 4 weeks of hypoxia. Systolic blood pressure increased moderately during 4 weeks of chronic hypoxia from 129+/-2 to 150+/-4 mmHg. This blood pressure increase was higher in rats treated for 4 weeks with an endothelin receptor antagonist (196+/-11 mmHg). CONCLUSIONS Chronic hypoxia (in contrast to acute hypoxia) suppresses renal renin gene expression. This inhibition presumably is mediated by endothelins.
Amino Acid Requirements for MDA5 and LGP2 Recognition by Paramyxovirus V Proteins: a Single Arginine Distinguishes MDA5 from RIG-I

ABSTRACT Paramyxovirus V proteins bind to MDA5 (melanoma differentiation-associated gene 5) and LGP2 (laboratory of genetics and physiology gene 2) but not RIG-I (retinoic acid-inducible gene I). The results demonstrate MDA5 R806 is essential for inhibition by diverse V proteins. Complementary substitution for the analogous RIG-I L714 confers V protein recognition. The analogous LGP2 R455 is required for recognition by measles V protein, but not other V proteins. These findings indicate that paramyxoviruses use a single amino acid to distinguish MDA5 from RIG-I and have evolved distinct contact sites for LGP2 interference.
PII-Regulated Arginine Synthesis Controls Accumulation of Cyanophycin in Synechocystis sp. Strain PCC 6803

ABSTRACT Cyanophycin (multi-l-arginyl-poly-l-aspartic acid) is a nitrogen storage polymer found in most cyanobacteria and some heterotrophic bacteria. The cyanobacterium Synechocystis sp. strain PCC 6803 accumulates cyanophycin following a transition from nitrogen-limited to nitrogen-excess conditions. Here we show that the accumulation of cyanophycin depends on the activation of the key enzyme of arginine biosynthesis, N-acetyl-l-glutamate kinase, by signal transduction protein PII.