Miracle-dz/UniFAR-FTUs huggingface dataset:
Enabling offline access to Facebook streams on mobile devices

The recent years have witnessed the wild success of social networks and social media sites such as Facebook, Twitter, LinkedIn, Google+, and Instagram -- indeed, many people rely on these social networks to communicate with their friends, family and community on a day to day basis. Via these sites, users exchange rich media contents, such as video, audio, and images for an enhanced user experience. With the growing popularity of mobile communications, users connect to these social networks using mobile devices (e.g., smartphones, tablets) and expect to derive the same experience no matter how and where they connect. It is reported that 93% of Android smartphone users in India use social networks on their smartphones [6]. Another survey, done in Canada, shows that 61% of users access Facebook through mobile devices [2]. These market reports indicate that social media streams, carrying rich content, have become key aspects of how people view information and how society interacts today.
P.4.b.015 Which factors influence onset and latency to treatment in generalized anxiety disorder, panic disorder and obsessive-compulsive disorder?

Anxiety disorders are common, comorbid, and disabling conditions, often underdiagnosed and under-treated, typically with an early onset, chronic course, and prolonged duration of untreated illness. The present study aimed to explore the influence of sociodemographic and clinical factors in relation to onset and latency to treatment in patients with generalized anxiety disorder (GAD), panic disorder (PD), and obsessive–compulsive disorder (OCD). A total of 157 patients with a Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Text Revision (DSM-IV-TR) diagnosis of PD (n=49), GAD (n=68), and OCD (n=40) were recruited, and epidemiological and clinical variables were collected through a specific questionnaire. Statistical analyses were carried out to compare variables across diagnostic groups. PD, GAD, and OCD patients showed a duration of untreated illness of 53.9±81.5, 77.47±95.76, and 90.6±112.1 months, respectively. Significant differences between groups were found with respect to age, age of first diagnosis, age of first treatment, family history of psychiatric illness, onset-related stressful events, benzodiazepine prescription as first treatment, antidepressant prescription as first treatment, and help-seeking (self-initiated vs. initiated by others). Patients with GAD, PD, and OCD showed significant differences in factors influencing onset and latency to treatment, which may, in turn, affect condition-related outcome and overall prognosis. Further studies with larger samples are warranted in the field.
A Fórmula de Black precifica corretamente as opções de compra sobre futuros agropecuários no Brasil? Uma aplicação para o caso do café Arábica

O aumento da importância dos instrumentos privados de gestao de risco na agricultura brasileira, especialmente os mercados futuros, torna essencial determinar a eficacia de instrumentos de precificacao que auxiliem os agentes do agronegocio a operarem nos mercados futuros do pais. O objetivo deste trabalho foi assim de avaliar se a Formula de Black precifica corretamente as opcoes de compra sobre futuros agropecuarios de cafe arabica da BM&F. Os resultados mostram que o desempenho do Modelo de Black e adequado apenas para opcoes forado-dinheiro, e somente utilizando-se a volatilidade implicita como medida da variabilidade dos precos dos contratos futuros.
Poststroke Neurogenesis: Emerging Principles of Migration and Localization of Immature Neurons

Stroke induces proliferation of newly born neurons in the subventricular zone, migration of these immature neurons away from the SVZ, and localization within peri-infarct tissues. These 3 processes of proliferation, migration, and localization constitute distinct spatial and temporal zones within poststroke neurogenesis with distinct molecular and cell-cell signaling environments. Immature neurons migrate after stroke in close association with blood vessels and astrocytic processes, in a process that involves matrix metalloproteinases. This poststroke migration shares similar features with normal neuroblast migration in the rostral migratory stream. Immature neurons localize in the peri-infarct cortex in a neurovascular niche where neurogenesis is causally linked to angiogenesis through the vascular factors SDF-1 and angiopoietin-1. Other vascular and neuronal growth factors have also been linked to poststroke neuroblast localization in peri-infarct tissue, including erythropoietin. Most data on poststroke neurogenesis derive from laboratory rodents, which may have an abnormal or blunted degree of neurogenesis and neuroplasticity compared to normal, wild rodents. This will likely affect translational application of the principles of poststroke neurogenesis from mouse to man. NEUROSCIENTIST 14(4):369–380, 2008. DOI: 10.1177/1073858407309545
A high-performance, low-voltage, body-driven CMOS current mirror

A novel high-performance low-voltage CMOS current mirror is proposed. The circuit is based on body-driven CMOS technology and implements gain-enhancement technique. It offers high transfer accuracy over wide current range, extremely high output impedance that makes it suitable for current output stage and ultra low input voltage requirement down to very close to 0 V. Simulation results using 0.18 /spl mu/m N-well CMOS technology confirm the excellent performance of this novel current mirror.
Multiple-bit parallel CDMA data transfer over common bus

An adaptive multiple-chip parallel CDMA interconnect (AMP-CDMA), that can enable parallelism and concurrency in communication by moderately increasing a complexity of the system, is proposed in this paper. The proposed technique enables to send simultaneously more than one bit data at each clock interval. The length of codewords is adjusted depending on how many modules exist in a system. Absolute quantitative performance metrics that correspond to the number of equivalent logic gates and communication latency were used to analyze the quality of four different design solutions of the proposed FPGA based communication architectures.
Un cÃ³digo de buenas prÃ¡cticas para la supervivencia de la empresa de familia

Las empresas de familia tienen dos características bien distintivas: (1) la gran contribución que realizan al desarrollo de las economías donde actúan y (2) la altísima probabilidad de desaparecer en sus primeros años de vida. Para superar esta amenaza es necesario recurrir a las herramientas que nos provee la disciplina llamada gobernancia corporativa. Ésta hace especial hincapié en los problemas organizacionales que se derivan de la separación entre la propiedad y el control de la firma; en este trabajo, sin embargo, nos proponemos estudiar la gobernancia de una empresa que aún concentra la propiedad y el control, utilizando instrumentos de la gobernancia corporativa, como un código de buenas prácticas, para ordenar la correcta interacción de sus instituciones. La columna vertebral de la necesaria transformación será entonces este código de buenas prácticas, que nos permite avanzar en pos de la supervivencia de la organización y su crecimiento continuo.
CS 224 W Final Project Report : Network Analysis of Convolutional Neural Networks ’ Weights on Images

The topological properties of images have been studied for a variety of applications, such as classification, segmentation, and compression. For the application of image classification, high classification accuracy has been achieved by machine learning models, especially convolutional neural networks (CNNs), and we seek to understand the reasons behind their success. In our project, we apply network analysis to describe, visualize, and analyze topological properties of the weights learned from a CNN classifier trained on digit images from the MNIST data set.
Insulin and IGF‐1 receptors contain covalently bound palmitic acid

We have studied the biosynthesis of the insulin receptor in a human hepatoma cell line, HepG2. As previously reported, these cells synthesize a disulphide–bonded α2 β2 tetrameric insulin receptor. Labelling of HepG2 cells with [3H]palmitate or [3H]myristate followed by immunoprecipitation with a polyclonal antireceptor antibody revealed the incorporation of palmitate, but not myristate, into the β‐subunit and αβ‐precursor of the receptor in a hydroxylamine‐sensitive linkage. The extracellular α‐subunit was not labelled, demonstrating the specificity of incorporation. Acylation of the insulin receptor was an early event as judged by fatty acid incorporation into the αβ‐precursor and prevention by protein synthesis inhibitors. Pulse‐chase studies demonstrated the expected processing of the αβ‐precursor to mature α‐ and β‐subunits, but no evidence for preferential turnover of the fatty acid moiety was found. The site of acylation appears to be in the transmembrane or cytoplasmic domain since proteolytic treatment of intact cells produced a truncated β‐subunit still containing label. Binding studies showed that HepG2 cells contain approximately half as many insulin‐like growth factor‐1 receptors as insulin receptors, raising the possibility that this receptor may also be acylated. Indeed, immunoprecipitation with the antiinsulin receptor serum of MDCK cells expressing IGF‐1 receptors, but not insulin receptors, revealed bands corresponding to the αβ‐precursor, α‐ and β‐subunits, of which the αβ‐precursor and β‐subunits incorporated [3H]palmitate but the α‐subunit did not.
I. SOME LAGRANGE INTERPOLATION FUNCTIONS FOR SOLENOIDAL AND IRROTATIONAL VECTOR FIELDS

Dedicated to Louis B. Holdeman & Edward G. Miller, fallen friends. Our ranks thin. March on! Abstract. Some remarkable new Lagrange interpolationfunctions on rectan- gular Cartesian meshes in two dimensions, and rectangular hexahedral meshes in three dimensions, are developed. The first examples are linearly-complete with a common (constant) divergence or a common (constant) curl on each element or subdomain of the mesh. These are extended to quadratic-complete functions, and then extended to orthogonal curvilinear coordinate systems, and ane meshes in those systems. After revisiting the equation of motion for incompressible flow, the functions, with suitable constraints, are used with the finite element method (FEM) to solve the incompressible Stokes equation. It is perhaps surprising how limited the class of interpolation functions for in- terpolating solenoidal or irrotational fields while preserving the solenoidal or irro- tational properties in a strong or pointwise sense is, and how elusive the search for better functions has been, particularly in three dimensions. The goal would be to find functions which are suciently continuous to be completely divergence- or curl-free. The latter could be satisfied by taking the curl or gradient of a "potential" function, but the class of recognized potential functions with sucient continuity has been very small. Ultimately, the solution lies in the class of Hermite inter- polation functions with the span of the curl in the space of functions H(div,), square-integrable with square-integrable curl over the domain , or with the span of the gradient in the space of functions H(curl,), square-integrable with square- integrable gradient. As a first step toward this goal, we demonstrate suciently continuous Lagrange interpolation functions with the properties that their diver- gences or curls have a common functional form. Then with a linear constraint, the sum of the contributions from the various nodes can be made to cancel. The Lagrange interpolation functions to be described are very useful in their own right, but they are also are the basis for developing the Hermite functions to be described in a later paper (6). The unqualified use of the term "divergence-free" in this paper means strongly or pointwise divergence-free in the problem domain, including the interfaces be- tween the subdomains or elements. This is in contrast to "weakly divergence-free,"
Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

Coordinated expression of mitochondrial and nuclear genes is required to maintain proper mitochondrial function. However, the precise mechanisms that ensure this coordination are not well defined. We find that signaling from mitochondria to the nucleus is influenced by mammalian target of rapamycin (mTOR) activity via changes in autophagy and p62/SQSTM1 turnover. Reducing mTOR activity increases autophagic flux, enhances mitochondrial membrane potential, reduces reactive oxygen species within the cell, and increases replicative life span. These effects appear to be mediated in part by an interaction between p62/SQSTM1 and Keap1. This interaction allows nuclear accumulation of the nuclear factor erythroid 2‐like 2 (NFE2L2, also known as nuclear factor related factor 2 or NRF2), increased expression of the nuclear respiratory factor 1 (NRF1), and increased expression of nuclear‐encoded mitochondrial genes, such as the mitochondrial transcription factor A, and mitochondrial‐encoded genes involved in oxidative phosphorylation. These findings reveal a portion of the intracellular signaling network that couples mitochondrial turnover with mitochondrial renewal to maintain homeostasis within the cell and suggest mechanisms whereby a reduction in mTOR activity may enhance longevity.
Evidence for sex‐specific selection in brain: a case study of the nine‐spined stickleback

Theory predicts that the sex making greater investments into reproductive behaviours demands higher cognitive ability, and as a consequence, larger brains or brain parts. Further, the resulting sexual dimorphism can differ between populations adapted to different environments, or among individuals developing under different environmental conditions. In the nine‐spine stickleback (Pungitius pungitius), males perform nest building, courtship, territory defence and parental care, whereas females perform mate choice and produce eggs. Also, predation‐adapted marine and competition‐adapted pond populations have diverged in a series of ecologically relevant traits, including the level of phenotypic plasticity. Here, we studied sexual dimorphism in brain size and architecture in nine‐spined stickleback from marine and pond populations reared in a factorial experiment with predation and food treatments in a common garden experiment. Males had relatively larger brains, larger telencephala, cerebella and hypothalami (6–16% divergence) than females, irrespective of habitat. Females tended to have larger bulbi olfactorii than males (13%) in the high food treatment, whereas no such difference was found in the low food treatment. The strong sexual dimorphism in brain architecture implies that the different reproductive allocation strategies (behaviour vs. egg production) select for different investments into the costly brains between males and females. The lack of habitat dependence in brain sexual dimorphism suggests that the sex‐specific selection forces on brains differ only negligibly between habitats. Although significance of the observed sex‐specific brain plasticity in the size of bulbus olfactorius remains unclear, it demonstrates the potential for sex‐specific neural plasticity.
Infliximab treatment induces levels of the active azathioprine metabolite TGTP in Crohn's disease.

REFERENCES 1. Park SH, Yang SK, Lim YS, et al. Clinical courses of chronic hepatitis B virus infection and inflammatory bowel disease in patients with both diseases. Inflamm Bowel Dis. 2012;18:2004–2010. 2. Gisbert JP, Chaparrow M, Esteve M. Review article: prevention and management of hepatitis B and C infection in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2011;33:619–633. 3. Hou JK, Velayos F, Terrault N, et al. Viral hepatitis and inflammatory bowel disease. Inflamm Bowel Dis. 2010;16:925–932. 4. Yeung JH, Goodman KJ, Fedorak RN. Inadequate knowledge of immunization guidelines: a missed opportunity for preventing infection in immunocompromised IBD patients. Inflamm Bowel Dis. 2012;18:24–40. 5. Wasan SK, Coukos JA, Farraye FA. Vaccinating the inflammatory bowel disease patient: deficiencies in gastroenterologist knowledge. Inflamm Bowel Dis. 2011;17:2536–2540.
The Big Finger: the second to fourth digit ratio is a predictor of sporting ability in women

Background: The second to fourth finger length ratio (2d:4d) is thought to be related to diverse traits including cognitive ability, disease susceptibility, and sexuality. Objective: To examine the relationship between 2d:4d and sports ability in women. Methods: Hand radiographs from 607 women (mean age 54 years) were used to estimate 2d:4d. Ranking of sports ability was on a scale (1–5). Results: The highest achieved level of participation in any sport was significantly negatively associated with 2d:4d (b = −4.93, p = 0.01) as was the relationship between 2d:4d and running level (b = −6.81, p = 0.034). Ability in other sports also showed a negative relationship albeit non-significant. Conclusions: These results suggest that a low 2d:4d ratio is related to increased female sports ability. It can be postulated that this ratio may predict potential sports ability. Understanding the mechanisms underpinning this relationship may give important insights into musculoskeletal fitness, health and disease.
On the epithelial-mesenchymal transition of mesothelial cells.

To the Editor: In a recently published review article, Williams et al1, on behalf of the Biopsy Registry Study Group, to which some of us belong, raise several criticisms regarding the paper published by our group in the New England Journal of Medicine2 without first consulting us or taking into account our opinion. In general, these comments are not scientifically based and appear to be personal opinions.
The Use of Extended Credit (Channel Stuffing) to Avoid Reporting Losses

This study investigates whether managers grant extended credit at the end of the fiscal year to accelerate customer purchases and thus avoid reporting losses. This study also considers whether this kind of earnings management affects the information content of reported earnings, and whether the unexpected accounts receivable (UAR)—a relatively reliable measure of management's exercise of channel stuffing over earnings—can provide incremental information about this phenomenon. Consistent with our hypotheses, we find that managers are likely to grant extended credit at the end of the fiscal year to meet their annual financial reporting targets.
Histomorphometric Evaluation of Direct Laser Metal Forming (DLMF) Implant Surface in the Type IV Bone: A Controlled Study in Human Jaw

Background and objectives. Direct laser metal forming (DLMF) is a procedure in which a high power laser beam is directed on a metal powder bed and programmed to fuse particles according to a CAD file, thus generating a thin metal layer. This surface produces structures with complex geometry and consequently allows better osteconductive properties. This study evaluated the influence of two different implant surfaces on the % bone-to-implant contact (BIC%) and bone density in the human type IV bone after 2 months of unloaded healing. Materials and Methods. The micro-implants utilized presented DLMF surface and a machined (As-M) surface serving as test and control, respectively. Sixteen subjects (67.5±4.3 years of age) received one implant each during conventional implant surgery in the posterior maxilla. After 8 weeks, the micro-implants and the surrounding tissue were removed and prepared for histomorphometric analysis. Results. Two As-M implants were found to be clinically unstable at time of retrieval. Histometric evaluation showed significantly higher BIC% and bone density for the test compared to the control surface (p<0.05). Discussion and Conclusion. The histologic data suggests that the DLMF surface implants positively modulated bone healing at early implantation times compared to the As-M, at least after 2 months unloaded healing.
The pathophysiology and management of thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura (TTP) is a disseminated form of thrombotic microangiopathy that manifests with thrombocytopenia, microangiopathic hemolytic anemia, fluctuating neurological symptoms, renal dysfunction and fever (1). It was first recognized by Dr Eli Moschowitz in 1925 (2) who used the term “acute febrile pleiochromic anemia with hyaline thrombosis of terminal arterioles and capillaries” to describe the case of a 16yr-old girl with anemia, petechiae, fever, slight paralysis and proteinuria. Four similar cases were then reported as “anemia and thrombocytopenic purpura” ( 3 ) by George Baehr who first suggested the role for intravascular platelet aggregation in the pathogenesis of the disease. To describe the syndrome the term “thrombotic thrombocytopenic purpura” was then introduced in 1947 by Karl Singer (4). A few years later, in 1955, the term “hemolytic uremic syndrome” (HUS) was used by Von Charlotte Gasser ( 5 ) to describe 5 childhood cases of thrombocytopenia, Coomb’s negative hemolytic anemia and renal failure. The term “thrombotic thrombocytopenic purpura of children” was then used by Anthony Allison in 1957 to describe 6 additional similar cases. In fact, both TTP and HUS describe syndromes of thrombocytopenia and Piero Ruggenenti MD12 and Giuseppe Remuzzi MD12
Effects of Tamm-Horsfall protein on polymorphonuclear leukocyte function.

BACKGROUND Tamm-Horsfall protein (THP), a glycoprotein produced exclusively by renal tubular cells, is thought to be involved in several inflammatory disorders such as bacterial interstitial nephritis as well as in defence against uropathogenic microorganisms. The specific effects of THP on inflammatory cells, however, are not yet well known. Therefore, the present study investigates the effects of THP in its soluble form on distinct polymorphonuclear leukocyte (PMNL) functions. METHODS PMNL were isolated from the venous blood of healthy adult donors and incubated at low THP concentrations (70-350 ng/ml), resembling plasma concentrations, and at high THP concentrations (1.75-8.75 micro g/ml), resembling urinary concentrations. RESULTS High (urinary) THP concentrations inhibited PMNL apoptosis and chemotaxis and stimulated PMNL phagocytosis, while low (plasma) THP concentrations increased PMNL chemotaxis. CONCLUSIONS These data indicate that THP influences several PMNL functions, suggesting a crucial immunomodulatory role for this glycoprotein in host defence mechanisms of the kidney and genitourinary tract.
A nonlinear adaptive H∞ tracking control design in robotic systems via neural networks

An adaptive neural-network tracking control with a guaranteed H/sup /spl infin// performance is proposed for robotic systems with plant uncertainties and external disturbances. A neural-network system is introduced to learn these unknown (or uncertain) dynamics by an adaptive algorithm, Moreover, the effects on the tracking error due to the approximation error via the adaptive neural network must be attenuated to a prescribed level, i.e. an H/sup /spl infin// tracking performance is achieved. Hence, in this study, both the H/sup /spl infin// tracking theory and adaptive neural-network control scheme are combined together to achieve the nonlinear adaptive H/sup /spl infin// tracking control design for uncertain or unknown robotic systems. The developed control scheme is smooth and semiglobal as well as very simple and computationally efficient, since it does not require a knowledge of either the mathematical model or the parameterization of the robotic dynamics. Finally, extensive simulations are given to illustrate the tracking performance of a two-link robotic manipulator with the proposed adaptive neural H/sup /spl infin// control design.