Miracle-dz/UniFAR-FTUs huggingface dataset:
Childhood adversities, adult risk factors and depressiveness: a population study.

OBJECTIVE Childhood adversities have been associated with adulthood depressiveness, but the contribution of adult risk factors is seldom described. We examined whether adult risk factors lie on the pathway from childhood adversity to adult depressiveness (pathway hypothesis) or whether the association depends on life events (vulnerability hypothesis). METHOD Among 21,101 randomly sampled working-aged respondents [the Health and Social Support in Finland (HeSSup) Study], the hypotheses were tested with logistic regression analysis models studying the associations between Beck Depression Inventory (BDI)-assessed depressiveness and self-reported childhood adversities alone and in combination with recent adverse events. RESULTS Childhood adversities were consistently associated with depressiveness (women, age-adjusted odds ratio 3.1, 95% confidence intervals 2.6-3.7; men, 2.6, 2.1-3.3), although the risks were decreased by more than 30% after adjustments for adult risk factors such as living alone, education, alcohol consumption, social support and negative affectivity. Childhood adversities combined with recent life events were associated with depressiveness in an additive manner. Women with childhood adversities and recent person-independent events especially had increased vulnerability for depressiveness. CONCLUSIONS The childhood adversity-depressiveness associations were partly mediated by adult risk factors, supporting a pathway from childhood adversities to depressiveness through adult risk factors. Increased vulnerability for depressiveness was found among respondents with childhood adversities in combination with recent death/illness events. The findings emphasize the importance of early risk factors when identifying persons at risk of depression.
Different modes of ozone-induced lipid oxidation in Candida utilis yeast cells and isolated membrane preparations.

Significant differences in the development of ozonolysis of lipids in membrane preparations and intact cells of the Candida utilis yeast were revealed. First, unlike isolated membranes, in which lipid modifications can be initiated by low ozone doses (< 0.5 micromol O3/mg protein) and develop proportionally to the treatment dose, in intact yeast cells, even the most ozone-sensitive sterols and nitrogen-containing phospholipids (phosphatidylcholine and phosphatidylethanolamine) did not undergo oxidative destruction at doses up to 6.0 micromol O3/mg protein. Second, the peculiarity of the ozone-initiated lipid modification in intact cells was that different classes of lipids exhibited different sensitivity to ozone. With an increase in the ozone dose, neutral lipids (sterols) and nitrogen-containing phospholipids (phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin) were modified to a greater extent. Third, the accumulation of lipid peroxidation products upon ozone treatment of cells, in contrast to the isolated membranes, was absent at low ozone doses and was recorded only after the lethal damage. It is suggested that these differences are related to both the function of antioxidative enzymes (catalase, superoxide dismutase, peroxidase, etc.) and the difference between the structural states (i.e., stability and accessibility to oxidation) of lipids in the isolated membranes and the intact cells.
Determinación de las zonas radiculares activas en el olivar regado gota a gota

6 paginas, 3 figuras, 8 referencias. Comunicacion presentada ante el citado Congreso que tuvo lugar en Sevilla, del 26 al 30 de septiembre de 1988. Publicada en la Seccion I: Fisica de Suelos. Otras comunicaciones presentadas por el IRNAS: http://hdl.handle. net/10261/47681. http://hdl.handle. net/10261/37273. http://hdl.handle. net/10261/37029. http://hdl.handle. net/10261/54668.
The nasal mast cell and rhinitis

Population studies identify the relevance of atopy lo the development of rhinitis and relate this disetise to the propensity to produce excessive specific IgE 111. In tissues igE is primarily bound by its Fc portion to mast ceils, which possess approximately 300000 high-affinity ¥cc. \ receptors 121. In sensitized individuals, exposure lo allergen leads to cross-linking of cell surface bound IgE and the initiation of a series of membrane and cytoplasmic events culminating in the release of ihe granule associated pre-formed mediators and the de novo synthesis of newly generated mediators. Histamine is a major preformed mediator, with the granules also containing ihc proicolytic enzyme tryptase, the proteoglycan heparin, and the acid hydrolases (/J-glucuronidasc. /? -hcxosaminidase. figalactosidase and arylsulphutase). while immunological degranulation of human mast cells is also associated wiih the synthesis and release of the arachidonie acid metabolites, prostuglandin (PG) D̂ . and leukotrienes (LTs) B4 and C4. It is the local release of these mediators within the nose that is implicated in the pathogenesis of the nasal symptoms of prurilis. sneezing, anterior rhinorrhoea and congestion which characterize allergic rhinitis.
FPGA based realization of OFDM transceiver system for Software Defined Radio

This paper describes the design and implementation of OFDM transmitter and Receiver in Partial Reconfigurable (PA) FPGA for Software Defined Radio (SDR) system. PR blocks inside FPGA helps in reducing the complexity in SDR system design, overall power and area consumption. The OFDM transceiver is designed with scalable FFT/IFFT- and three types of modulations. An intelligent receiver design is being used, which identifies the type of modulation employed based on the features present in receiving signal and reprograms demodulation circuit at run time without changing much in other baseband processing modules. Further, A unique technique of Peak to Average Power Ratio (PAPR) reduction is being implemented.
Occult atrial fibrillation in ischemic stroke

Physicians frequently evaluate patients with recent ischemic strokes or transient ischemic attacks (TIA) and perform diagnostic evaluations only to find no clear demonstrable etiology in fully one-third of cases. Cryptogenic stroke remains a diagnostic category of exclusion and encompasses a broad range of patients with varied risk factors, comorbid conditions, and radiographic patterns of cerebral infarction. In contrast, atrial fibrillation (AF) is a common and well-defined cause of ischemic stroke, representing 50% of cardioembolic stroke and 10% of all ischemic strokes, often resulting in severe neurologic disability.1 AF can be readily diagnosed by electrocardiography, and has known risk factors, pathophysiology, and therapeutic options, including anticoagulation. Approximately 25% of patients with AF have intermittent AF that is often asymptomatic and undetected by conventional methods of brief cardiac telemetry monitoring.1,2 Patients who are initially diagnosed with cryptogenic stroke or TIA can be found subsequently to have intermittent AF, suggesting that efforts to improve AF detection are warranted. An optimal telemetry monitoring method for the detection of occult AF could identify stroke patients at risk for recurrent cardioembolic stroke and a subgroup that may benefit from anticoagulation. Paroxysmal AF (PAF) is believed to carry the same stroke risk as continuous AF; however, patients with PAF exhibit a …
Phenolic Content, Antioxidant and Antimicrobial Activities of Egyptian and Chinese Propolis

Propolis is a resinous mixture that honeybees collect from tree buds, sap flows, or other botanical sources. It is used as a sealant for unwanted open spaces in the hive. Propolis is sticky at and above room temperature, 20°C (68°F). At lower temperatures, it becomes hard and very brittle. The aim of this study is to explore the phenolic contents and identify of the Egyptian and Chinese propolis and their biological activity potentiality, especially antioxidant and antimicrobial activity. Egyptian and Chinese propolis contained considerable amounts of phenolic compounds. The Egyptian propolis contains phenolic content a little bit greater than Chinese propolis. The Egyptian propolis showed an antioxidant activity higher than Chinese. IC of Egyptian propolis was (73.49 µg/ml) and (81.67 µg/ml) for Chinese propolis, whereas the IC for 50 50 L-Ascorbic acid as positive control was (39.62 µg/ml). The HPLC analysis of Egyptian and Chinese propolis approved reasonable and different concentrations of phenolic compounds in both Egyptian and Chinese Propolis. The Egyptian propolis contains high concentration levels of tannic acid (10.64 µg/g), catechol (8.12 µg/g) and caffeic acid (7.435 µg/g). The Egyptian propolis showed a highest toxicity against Bacillus subtilis DB 100 host and Streptococcus sp. (IZD= 18 and 20 mm) respectively. On the other hand, Chinese propolis showed a highest antimicrobial activity and toxicity against Candida albicans and Bacillus subtilis (IZD=20mm) for both strains.
Diffuse-adhering Escherichia coli (DAEC) as a putative cause of diarrhea in Mayan children in Mexico.

Diarrhea is a major cause of infantile morbidity and mortality in developing countries. A community-based, case control study was conducted in a southern Mexican Mayan village for 3 weeks during the peak diarrhea period to prospectively identify the infectious agents associated with childhood diarrheal disease. Several enteropathogens were isolated from stools of 34 of 58 cases, although none was significantly associated with diarrhea. For the 24 cases from which no enteropathogens were isolated, diffuse-adhering Escherichia coli (DAEC) strains were significantly associated with diarrheal disease (P less than .02; odds ratio = 6; 95% confidence limit, 1.08-99.0). DAEC were highly heterogeneous with respect to plasmid content and serotype. Three DNA probes designed to differentiate E. coli exhibiting localized, diffuse, or aggregative adherence were compared with results from a standard HeLa cell binding assay to assess the utility of these probes in the field. This study provides evidence for the potential pathogenic capacity of DAEC and underscores the variety of diarrheal agents operating within a community.
Simplified reaction kinetics, models and experiments for glyphosate degradation in water by the UV/H_2O_2 process

A simplified mathematical model to describe the oxidative degradation of glyphosate employing hydrogen peroxide and UV radiation was developed based on a sequence of predominant reactions. The kinetics obtained include all the required significant variables. Consequently, not only were concentration dependencies examined but also the influence of a detailed spatial description of the radiation field was included as part of the modeling. The kinetic parameters were obtained by comparing the simulation concentrations obtained with the model with the experimental values gathered in the laboratory reactor, employing a multiparameter non-linear regression analysis. In addition, the potential of the H_2O_2/UV process for treating water polluted with a commercial formulation, which was the glyphosate monoisopropylamine salt plus some additives, was studied. The glyphosate and TOC (total organic carbon) conversions reached were close to 80% and 70% respectively at 12 h (0.66 h actual exposure to radiation). It has been shown that a simple reaction scheme for the degradation of glyphosate acid and glyphosate isopropylamine salt from a commercial formulation can represent with good accuracy the performance of both reacting systems. In addition, the degradation procedure allowed a clear reduction of the toxicity of the glyphosate in the formulation over Vibrio fischeri at the end of the experiments. For this reason, reaching complete mineralization might not be necessary.
Postnatal maturation of the GABAergic system in rat neocortex.

1. The postnatal maturation of intracortical inhibitory circuitry and the development of responses to applied gamma-aminobutyric acid (GABA) and baclofen were studied in pyramidal and nonpyramidal neurons from layers II and III of the rat primary somatosensory and primary visual cortex, in vitro. 2. Depolarizing spontaneous inhibitory postsynaptic potentials (IPSPs) could be recorded in approximately 70% of the young (postnatal day 4-10; P4-10), juvenile (P11-16), and adult cells (P28-41), respectively, when they were loaded with nitrate. At all ages these spontaneous events could be blocked by application of the GABAA receptor antagonist bicuculline methiodide (BMI), indicating that they were mediated by activation of GABAA receptors. 3. In 122 of the 130 adult cells tested, standardized electrical stimulation of the white matter or layer VI evoked a brief excitatory postsynaptic potential (EPSP), followed by both a fast (f-) and a long-latency (l-)IPSP. Similar stimuli evoked a biphasic IPSP in only 51 of the 98 juvenile and in only 1 of the 56 young neurons studied. The mean peak conductance of the f-IPSP and the l-IPSP increased significantly from 50.2 and 7.5 nS, respectively, in juvenile cells to 84.2 and 18.0 nS, respectively, in adult neurons. 4. Application of the N-methyl-D-aspartate (NMDA) receptor antagonist D-amino-phosphonovaleric acid (D-APV) to juvenile cells induced a significant negative shift in the reversal potential of both the f-IPSP and l-IPSP. This effect was accompanied by a reduction in the peak conductance during these events by 31 and 48%, respectively, indicating that a prominent long-lasting NMDA receptor-mediated EPSP occurs concurrent with the early and late IPSP in immature neurons. In adult neurons, D-APV had no significant effect on the reversal potential of the f- and l-IPSP, although the peak conductance decreased by 20 and 5%, respectively, suggesting that there was a smaller concurrent activation of NMDA receptors in this age group. 5. The functional maturation of GABAA and GABAB receptors was studied using focal applications of GABA to the soma and the apical dendrite. Somatic GABA applications to adult neurons held at depolarized membrane potentials evoked a triphasic response, consisting of 1) a GABAA-mediated hyperpolarizing fast component (GABAhf; reversal potential, -76 mV), 2) a GABAA-mediated depolarizing phase (GABAd; -54 mV), and 3) a hyperpolarizing late response (GABAhl; -80 mV). The GABAd response could be demonstrated at all ages in almost every neuron. (ABSTRACT TRUNCATED AT 400 WORDS)
Involvement of reactive oxygen intermediates in tumor necrosis factor alpha-dependent bacteriostasis of Mycobacterium avium

We studied the involvement of reactive oxygen intermediates and reactive nitrogen intermediates in the bacteriostasis of two Mycobacterium avium strains differing in virulence by resident peritoneal macrophages. We found that both the highly virulent strain (25291) and the low-virulence strain (1983) of M. avium induced superoxide production but inhibited nitrite production in vitro. This inhibition was due to the production of superoxide, a nitric oxide scavenger. The stimulation of superoxide production was two- to fivefold higher in strain 1983-infected than in strain 25291-infected resident peritoneal macrophages and was independent of contaminating T cells or NK cells. Superoxide secretion was dependent on the tumor necrosis factor (TNF) produced endogenously by the macrophages. This was also true when macrophages were isolated from infected mice. Addition of TNF to the infected resident peritoneal macrophages caused only a slight, albeit significant, increase in superoxide production by strain 25291-infected macrophages. Incubation of resident peritoneal macrophages with different scavengers of reactive oxygen intermediates showed that strain 1983 was susceptible to hydrogen peroxide produced by resident peritoneal macrophages. Strain 25291 was shown to decrease superoxide secretion inside heavily infected bone marrow-derived macrophages. This strain was also shown to be a better trigger for production of reactive oxygen intermediates than strain 1983. In summary, strain 1983 induced high levels of TNF synthesis that acted in an autocrine fashion to stimulate production of reactive oxygen intermediates by macrophages leading to growth restriction mediated by hydrogen peroxide. The highly virulent strain 25291 induced low levels of TNF synthesis, and therefore little reactive oxygen intermediate production, and could also inhibit superoxide production by the infected macrophages.
Computation of Temporal Betweeness and Analysis of a Knowledge Mobilization Network ∗

The temporal component of social networks is often neglected in their analysis, and statistical measures are usually performed on “static” network representations. As a result, measures of importance (like betweenness centrality) typically do not reveal the temporal role of the entities involved. Our goal is to contribute to fill this limitation by proposing a form of temporal betweenness measure (foremost betweenness) to analyse a knowledge mobilization network. We first describe a new algorithm to compute foremost betweenness, we then show that this measure, which takes time explicitly into account, allows us to detect centrality roles that were completely hidden in the classical statistical analysis. In particular, we uncover nodes whose static centrality was considered negligible, but whose temporal role is instead important to accelerate mobilization flow in the network. We also observe the reverse behaviour by detecting nodes with high static centrality, whose role as temporal bridges is instead very low. By revealing important temporal roles, this study is a first step towards a better understanding of the impact of time in social networks, and opens the road to further investigation.
Combined clinical and laboratory testing improves diagnostic accuracy for osteomyelitis in the diabetic foot.

UNLABELLED The purpose of this investigation was to examine the value of using routinely available clinical and laboratory tests in combination to distinguish osteomyelitis from cellulitis in a diabetic population with mild to moderately infected forefoot ulcers. We conducted a case-control study of 54 diabetic patients with 54 locally infected ulcers admitted to a university-affiliated tertiary-care hospital over a 4.5-year period. A total of 30 clinical and laboratory characteristics obtained at admission were tested for their association with pathology-proven osteomyelitis using logistic regression techniques. Ulcer depth greater than 3 mm (univariate odds ratio 10.4, P = .001) and C-reactive protein greater than 3.2 mg/dL (univariate odds ratio 10.8, P < .001) were the most informative individual clinical and laboratory tests for differentiating osteomyelitis from cellulitis. Adding C-reactive protein also significantly improved upon the accuracy of the study's best clinical testing strategy (area under the curve improved from 0.80 to 0.88, P = .040). Strategies that combined ulcer depth with serum inflammatory markers proved most useful in detecting ulcerated patients with concomitant bone infections (sensitivity 100% [95% CI 89.7%-100%] for both ulcer depth greater than 3 mm or C-reactive protein greater than 3.2 mg/dL, and ulcer depth greater than 3 mm or erythrocyte sedimentation rate greater than 60 mm/h). We conclude that considering clinical and laboratory findings together can significantly improve our diagnostic accuracy for osteomyelitis in the diabetic foot. The specific combination of ulcer depth with serum inflammatory markers appears to be a particularly sensitive strategy that may allow for greater detection of early diabetic osteomyelitis. LEVEL OF CLINICAL EVIDENCE 3.
Shock resuscitation with acupuncture: case report

A 77 year old aboriginal woman in an isolated village became drowsy and shocked. Poor weather conditions delayed the arrival of the medical and support team—the roads had been seriously destroyed by torrential rains and helicopter was the only means for delivering critical medical care and support. While waiting for the arrival of the helicopter, and in the absence of the necessary emergency medical equipment, the patient’s condition deteriorated. Administration of persistent emergency acupuncture stimulation for 80 minutes helped maintain the patient’s vital signs until successful transfer of the patient to hospital. She recovered without any complications of shock and was discharged six days later.
Fukaya categories and bordered Heegaard-Floer homology

We outline an interpretation of Heegaard-Floer homology of 3-manifolds (closed or with boundary) in terms of the symplectic topology of symmetric products of Riemann surfaces, as suggested by recent work of Tim Perutz and Yanki Lekili. In particular we discuss the connection between the Fukaya category of the symmetric product and the bordered algebra introduced by Robert Lipshitz, Peter Ozsvath and Dylan Thurston, and recast bordered Heegaard-Floer homology in this language.
Translation of an Efficacious Cancer-Screening Intervention to Women Enrolled in a Medicaid Managed Care Organization

PURPOSE An earlier randomized controlled trial of prevention care management (PCM) found significant improvement in breast, cervical, and colorectal cancer-screening rates among women attending Community Health Centers but required substantial research support. This study evaluated the impact of a streamlined PCM delivered through a Medicaid managed care organization (MMCO), an infrastructure with the potential to sustain this program for the long term. METHODS This randomized trial was conducted within an MMCO serving New York City between May 2005 and December 2005. A total of 1,316 women aged 40 to 69 years and not up to date for at least 1 targeted cancer-screening test were randomized to either PCM or a comparison group. Women in the PCM group received up to 3 scripted telephone calls to identify barriers and provide support to obtain any needed breast, cervical, and colorectal cancer-screening tests. Women in the comparison group received a modified version of the MMCO’s established mammography telephone outreach program, also in up to 3 calls. Women in both groups received a financial incentive on confirmation that they had received a mammogram. Screening status was assessed through MMCO administrative data. Groups were compared using odds ratios. RESULTS In an intent-to-treat comparison adjusted for baseline screening status, PCM women were 1.69 times more likely to be up-to-date for colorectal cancer-screening tests at follow-up than women in the comparison group (95% confidence interval, 1.03–2.77). Follow-up screening rates for cervical and breast cancer did not differ significantly between study groups on an intent-to-treat basis. CONCLUSIONS The abbreviated PCM telephone intervention was feasible to deliver through an MMCO and improved screening for 1 cancer. This approach has the potential to improve cancer-screening rates significantly in settings that can provide telephone support to women known to be overdue.