Miracle-dz/UniFAR-FTUs huggingface dataset:
Child and Youth Traffic-Related Injuries: Use of a Trauma Registry to Identify Priorities for Prevention in the United Arab Emirates

Objective: Traffic-related injuries are the main cause of death during childhood and youth in the United Arab Emirates (UAE), use of safety restraints by citizens is uncommon, rollovers are frequent, and current legislation does not protect rear-seat occupants. Because little was known about the circumstances of hospitalizations for traffic injuries to guide prevention, a trauma registry was used to assess causes and determinants for traffic-related injuries during childhood and youth (<19 years) and its value for prevention. Methods: One hundred ninety-three children and youth with traffic injuries were admitted for more than 24 h at surgical wards of the main trauma hospital in the Al-Ain region during a 36-month period (2003–2006). Injuries were analyzed by age, nationality, road user and vehicle types, severity, anatomical region, and the presence of head injury using Injury Severity Scores (ISS) and the Abbreviated Injury Scale (AIS). Results: Traffic injuries represented 40 percent (n = 193) of injuries to 0- to 19-year-olds, followed by falls (39 percent). Among 15- to 19-year-olds, who accounted for 46 percent of child and youth victims, the incidence was 150/100,000 person years, compared to an incidence of 15 to 51 for younger age groups. Overall, 53 percent were vehicle occupants, 23 percent were pedestrians, 14 percent were bicyclists, 6 percent were motorcyclists, with 4 percent other. The ratio of male-to-female victims was 6.7:1; for drivers it was 33:0; and for pedestrians, bicyclists, and motorcyclists it was between 10:1 and 12:1; injured females were mainly rear-seat passengers and the male: female ratio was 1.4:1. Seventy-one percent of pedestrians were ≤9 years old. Although the ratio of UAE children to foreign children was estimated at 0.7:1 in the community, 58 percent of the injured were UAE citizens. The ratio of injured UAE: non-UAE citizens was 1.4:1 overall but 5.6:1 for drivers and 4.5:1 for motorcyclists. Forty-one percent of citizens were injured in 4-wheel drive sport utility vehicles compared to 13 percent of non-citizens. Head injuries occurred in 68 percent of vehicle occupants and 51 percent of nonoccupants, with AIS ≥ 3 injuries in 23 percent of occupants and 26 percent of nonoccupants. Sixty-seven percent of rear occupants had head injuries. Conclusions: Male drivers and vulnerable road users were at an unusually high risk relative to females. A relatively high frequency of traffic-related head injuries among UAE children and youth, including rear-seat passengers and other vehicle occupants, suggests that considerable preventable morbidity is associated with nonuse of safety restraints and/or other factors such as excess speed and rollovers of 4-wheel drive vehicles. Trauma registries can be useful for prevention; inclusion of data on safety restraints and helmet use by road user type is essential.
Kaposi's Sarcoma-Associated Herpesvirus LANA2 Is a B-Cell-Specific Latent Viral Protein That Inhibits p53

ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, is associated with three proliferative diseases ranging from viral cytokine-induced hyperplasia to monoclonal neoplasia: multicentric Castleman's disease (CD), Kaposi's sarcoma (KS), and primary effusion lymphoma (PEL). Here we report a new latency-associated 1,704-bp KSHV spliced gene belonging to a cluster of KSHV sequences having homology to the interferon regulatory factor (IRF) family of transcription factors. ORFK10.5 encodes a protein, latency-associated nuclear antigen 2 (LANA2), which is expressed in KSHV-infected hematopoietic tissues, including PEL and CD but not KS lesions. LANA2 is abundantly expressed in the nuclei of cultured KSHV-infected B cells. Transcription of K10.5 in PEL cell cultures is not inhibited by DNA polymerase inhibitors nor significantly induced by phorbol ester treatment. Unlike LANA1, LANA2 does not elicit a serologic response from patients with KS, PEL, or CD as measured by Western blot hybridization. Both KSHV vIRF1 (ORFK9) and LANA2 (ORFK10.5) appear to have arisen through gene duplication of a captured cellular IRF gene. LANA2 is a potent inhibitor of p53-induced transcription in reporter assays. LANA2 antagonizes apoptosis due to p53 overexpression in p53-null SAOS-2 cells and apoptosis due to doxorubicin treatment of wild-type p53 U2OS cells. While LANA2 specifically interacts with amino acids 290 to 393 of p53 in glutathione S-transferase pull-down assays, we were unable to demonstrate LANA2-p53 interaction in vivo by immunoprecipitation. These findings show that KSHV has tissue-specific latent gene expression programs and identify a new latent protein which may contribute to KSHV tumorigenesis in hematopoietic tissues via p53 inhibition.
Vertical micromirrors integrated with electromagnetic microactuators for two-dimensional optical matrix switches

We report novel single crystalline silicon (SCS) micromirrors vertically attached to electromagnetic microactuators for the two-dimensional (2-D) free-space optical cross-connect switching application. The operation voltage is typically 0.7 V due to the large electromagnetic force generated by the coils on the microactuators. Vertical micromirrors with the surface area of 500/spl times/1200 /spl mu/m are monolithically integrated with microactuators. The micromirrors are fabricated by low-cost tetra-methyl ammonium hydroxide anisotropic wet etching on the [110] SCS wafers. The surface roughness of the micromirror is less than 20 nm and the measured insertion loss caused by the micromirror is approximately 0.2 dB. The large surface area of the micromirror can accommodate a big optical beam for 2-D matrix configuration to minimize insertion loss. Chips consisting of 10 /spl times/ 10 arrays are successfully fabricated and tested.
Optimal Methods in the Treatment of Ophthalmia Neonatorum

Myxoedema is a much commoner cause of psychosis than is usually believed. Treatment with thyroid usually cures the psychosis dramatically. Fourteen cases are described-nine recovered completely, two recovered partially, one showed no change, and two were fatal. There is no specific psychosis, but paranoid ideas are common. A description of myxoedema is given and methods of diagnosing it are reviewed. Photographs before and after thyroid treatment give the best confirmation of the diagnosis.
Signal denoising using wavelets and block hidden Markov model

This paper presents a new framework for signal denoising based on wavelet-domain hidden Markov models (HMMs). The new framework enables us to concisely model the statistical dependencies and non-Gaussian statistics encountered in real-world signals, and enables us to get a more reliable and local model using blocks. Wavelet-domain HMMs are designed with the intrinsic properties of wavelet transform and provide powerful yet tractable probabilistic signal models. In this paper, we propose a novel wavelet domain HMM using blocks to strike a delicate balance between improving spatial adaptability of contextual HMM (CHMM) and modeling a more reliable HMM. Each wavelet coefficient is modeled as a Gaussian mixture model, and the dependencies among wavelet coefficients in each subband are described by a context structure, then the structure is modified by blocks which are connected areas in a scale conditioned on the same context. Before denoising a signal, efficient Expectation Maximization (EM) algorithms are developed for fitting the HMMs to observational signal data. Parameters of trained HMM are used to modify wavelet coefficients according to the rule of minimizing the mean squared error (MSE) of the signal. Then, reverse wavelet transformation is utilized to modified wavelet coefficients. Finally, experimental results are given. The results show that block hidden Markov model (BHMM) is a powerful yet simple tool in signal denoising.
External Influence as an Indicator of Scholarly Importance

Although the external influence of scholars has usually been approximated by publication and citation count, the array of scholarly activities is far more extensive. Today, new technologies, in particular Internet search engines, allow more accurate measurement of scholars' influence on societal discourse. Hence, in this article, we analyse the relation between the internal and external influence of 723 top economists using the number of pages indexed by Google and Bing as a measure of external influence. We not only identify a small association between these scholars’ internal and external influence but also a correlation between internal influence, as captured by receipt of such major academic awards as the Nobel Prize and John Bates Clark Medal, and the external prominence of the top 100 researchers (JEL Code: A11, A13, Z18).
Cytoplasmic microtubule organization in fission yeast

During the cell cycle of the fission yeast Schizosaccharomyces pombe, striking changes in the organization of the cytoplasmic microtubule cytoskeleton take place. These may serve as a model for understanding the different modes of microtubule organization that are often characteristic of differentiated higher eukaryotic cells. In the last few years, considerable progress has been made in our understanding of the organization and behaviour of fission yeast cytoplasmic microtubules, not only in the identification of the genes and proteins involved but also in the physiological analysis of function using fluorescently‐tagged proteins in vivo. In this review we discuss the state of our knowledge in three areas: microtubule nucleation, regulation of microtubule dynamics and the organization and polarity of microtubule bundles. Advances in these areas provide a solid framework for a more detailed understanding of cytoplasmic microtubule organization. Copyright © 2006 John Wiley & Sons, Ltd.
Temporal Patterns of the Use of Non-Prescribed Drugs

Licit and illicit non-prescribed drugs, regardless of their classification, are used in a common temporal pattern with the possible exceptions of caffeine and cocaine. The temporal patterns of drug use are highly correlated with the nationwide temporal pattern of TV watching, suggesting a pleasure-oriented, recreational use. The peak times for substance use and abuse may have implications for the delivery of professional or paraprofessional services.
Emergence of Clinical Salmonella enterica Serovar Typhimurium Isolates with Concurrent Resistance to Ciprofloxacin, Ceftriaxone, and Azithromycin

ABSTRACT Salmonella infection is an important public health issue for which the needs of antimicrobial treatment are increasing. A total of 546 human clinical S. enterica serovar Typhimurium isolates were recovered from patients in hospitals in China during the period of 2005 to ∼2011. Twenty percent of the isolates exhibited resistance to ciprofloxacin, and 4% were resistant to ceftriaxone. Importantly, for the first time, 12 (2%) S. Typhimurium isolates resistant to both ciprofloxacin and ceftriaxone were recovered; among these 12 isolates, two were also resistant to azithromycin, and one was resistant to all other drugs tested. The combined effects of various transferrable extended-spectrum β-lactamase determinants and a novel efflux-based ciprofloxacin resistance mechanism encoded by the mobile efflux gene oqxAB were responsible for the emergence of these extremely (highly) drug-resistant (XDR) S. Typhimurium isolates. The dissemination of resistance genes, such as those encoding ESBLs and the OqxAB pump, among Salmonella organisms will speed up the selection of XDR Salmonella, posing a huge threat to public health and Salmonella infection control.
Efecto del gen cuello desnudo (Na) en el balance de calcio de gallinas criollas bajo condiciones de clima tropical seco

Con el objetivo de determinar el efecto del gen Na (cuello desnudo) en el balance de calcio en gallinas criollas en condiciones de clima tropical seco, se utilizaron 30 gallinas criollas: 10 gallinas NaNa (cuello desnudo homocigóticas), 10 Nana (cuello desnudo heterocigóticas) y 10 nana (emplume normal homocigóticas). El alimento ofrecido contenía 16 % de proteína cruda, 11.95 MJ de energía metabolizable por kg de alimento, 3.5 % de calcio y 0.45 % de fósforo disponible. Las semanas 34, 44 y 54 de edad se predeterminaron para la recolección de datos. Se midió el consumo de alimento, consumo de calcio, calcio excretado diurno, calcio excretado nocturno, calcio en cascarón y calcio sérico, en tres momentos relativos a la oviposición: con huevo en el útero, 7 h post-oviposición y el día que no puso huevo. No se encontró efecto significativo de genotipo, ni de las interacciones genotipo por edad y genotipo por momento de oviposición en los niveles
Smooth muscle cells of the media in the dilatative pathology of ascending thoracic aorta: morphology, immunoreactivity for osteopontin, matrix metalloproteinases, and their inhibitors.

The etiopathogenesis of thoracic aortic aneurysms is currently an issue of debate. The present study investigated ultrastructural, morphometric, and immunohistochemical aspects of smooth muscle cells (SMCs) in chronic aneurysm of the thoracic aorta (aneurysm group), aortic dilatation associated with valvular disease (valvular group), and dissection of the thoracic aorta (dissection group). Fragments of the ascending aorta that had been taken from the patients during coronary bypass surgery were used as controls. No significant difference was observed in the density of SMCs between the 3 pathologic groups put together and the controls. Only separate analysis of SMC density in each of the pathologic groups showed that the valvular group samples had significantly smaller amounts of SMCs in the internal layer of the media than the dissection group samples and controls. Ultrastructural analysis, in situ end labeling, propidium iodide assay, and DNA laddering did not show apoptosis of SMCs in the samples investigated. Ultrastructure of SMCs characteristic of the synthetic phenotype, together with increased expression of osteopontin in the media of pathologic thoracic aortas indicated the transition of SMCs from the contractile to the synthetic phenotype. Immunohistochemical investigation showed that medial SMCs in the samples taken from aortas of all 3 pathologic groups expressed stronger immunoreactivity for matrix metalloproteinase 1, 2, and 9 and tissue inhibitor of metalloproteinase 1 and 2 than the controls. The present study shows that during the formation of aneurysms, dissection of the thoracic aorta, or aortic dilatation associated with valvular disease, loss of SMCs was not of great importance with respect to their transition from the contractile to the synthetic type in leading to increased production of matrix metalloproteinases.
Simulation of Octopus Arm Based on Coupled CPGs

The octopus arm has attracted many researchers' interests and became a research hot spot because of its amazing features. Several dynamic models inspired by an octopus arm are presented to realize the structure with a large number of degrees of freedom. The octopus arm is made of a soft material introducing high-dimensionality, nonlinearity, and elasticity, which makes the octopus arm difficult to control. In this paper, three coupled central pattern generators (CPGs) are built and a 2-dimensional dynamic model of the octopus arm is presented to explore possible strategies of the octopus movement control. And the CPGs' signals treated as activation are added on the ventral, dorsal, and transversal sides, respectively. The effects of the octopus arm are discussed when the parameters of the CPGs are changed. Simulations show that the octopus arm movements are mainly determined by the shapes of three CPGs' phase diagrams. Therefore, some locomotion modes are supposed to be embedded in the neuromuscular system of the octopus arm. And the octopus arm movements can be achieved by modulating the parameters of the CPGs. The results are beneficial for researchers to understand the octopus movement further.
Images of foodscapes: Introduction to foodscape studies and their application in the study of healthy eating out-of-home environments

The notion of foodscape is increasingly being used within health promotion, public health nutrition and food studies as a tool to describe our food environments and to assess the potential impact on food choice and food behaviour. This paper takes a closer look at the growing number of foodscape studies (FSS) and traces the origin of the idea of foodscapes. It reflects on the different contributions and discusses the applicability within food research. In particular it discusses how the notion can be applied in the growing number of studies that investigate the role that captive eating out-of-home environments (CEOE) in public welfare systems has on the health of the individual and on the sustainability of the environment. The paper concludes that the idea of foodscapes is a convenient tool that has many applications in food research. The foodscape framework offers obvious advantages in that it enables scholars to analyse how food, places and people are interconnected and how they interact. In particular the paper concludes that the foodscape notion is well suited to the study of foodscapes in CEOEs such as schools, kindergartens and institutions. I finally suggest that such foodscapes can be defined as physical, organizational and sociocultural spaces in which clients/guests encounter meals, food and food-related issues including health messages.
The main auxin biosynthesis pathway in Arabidopsis

The phytohormone auxin plays critical roles in the regulation of plant growth and development. Indole-3-acetic acid (IAA) has been recognized as the major auxin for more than 70 y. Although several pathways have been proposed, how auxin is synthesized in plants is still unclear. Previous genetic and enzymatic studies demonstrated that both TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS (TAA) and YUCCA (YUC) flavin monooxygenase-like proteins are required for biosynthesis of IAA during plant development, but these enzymes were placed in two independent pathways. In this article, we demonstrate that the TAA family produces indole-3-pyruvic acid (IPA) and the YUC family functions in the conversion of IPA to IAA in Arabidopsis (Arabidopsis thaliana) by a quantification method of IPA using liquid chromatography–electrospray ionization–tandem MS. We further show that YUC protein expressed in Escherichia coli directly converts IPA to IAA. Indole-3-acetaldehyde is probably not a precursor of IAA in the IPA pathway. Our results indicate that YUC proteins catalyze a rate-limiting step of the IPA pathway, which is the main IAA biosynthesis pathway in Arabidopsis.
A fast feedforward training algorithm using a modified form of the standard backpropagation algorithm

In this letter, a new approach for the learning process of multilayer feedforward neural network is introduced. This approach minimizes a modified form of the criterion used in the standard backpropagation algorithm. This criterion is based on the sum of the linear and the nonlinear quadratic errors of the output neuron. The quadratic linear error signal is appropriately weighted. The choice of the weighted design parameter is evaluated via rank convergence series analysis and asymptotic constant error values. The new proposed modified standard backpropagation algorithm (MBP) is first derived on a single neuron-based net and then extended to a general feedforward neural network. Simulation results of the 4-b parity checker and the circle in the square problem confirm that the performance of the MBP algorithm exceed the standard backpropagation (SBP) in the reduction of the total number of iterations and in the learning time.
A DC to 30GHz ultra-wideband CMOS T/R switch

A differential low-cost T/R switch based on a 0. 18µm SiGe BiCMOS process with only CMOS components is developed. The proposed switch achieves an ultra-wide bandwidth of 30GHz. For single-end SPDT applications, the switch has 1.5dB to 3.3dB insertion loss and 20dB to 80dB isolation. Input/output matching has been realized from DC to 40GHz. The switch requires no biasing voltage except the 1.8V voltage supply and ground potentials, which greatly enhances its application feasibility. The switch also has a compact chip area of 0.025mm2 (for SPDT) and 0.05mm2 for differential SPDT applications.
Self-adaptive recurrent neuro-fuzzy control of an autonomous underwater vehicle

This paper presents the utilization of a self-adaptive recurrent neuro-fuzzy control as a feedforward controller and a proportional-plus-derivative (PD) control as a feedback controller for controlling an autonomous underwater vehicle (AUV) in an unstructured environment. Without a priori knowledge, the recurrent neuro-fuzzy system is first trained to model the inverse dynamics of the AUV and then utilized as a feedforward controller to compute the nominal torque of the AUV along a desired trajectory. The PD feedback controller computes the error torque to minimize the system error along the desired trajectory. This error torque also provides an error signal for online updating the parameters in the recurrent neuro-fuzzy control to adapt in a changing environment. A systematic self-adaptive learning algorithm, consisting of a mapping-constrained agglomerative clustering algorithm for the structure learning and a recursive recurrent learning algorithm for the parameter learning, has been developed to construct the recurrent neuro-fuzzy system to model the inverse dynamics of an AUV with fast learning convergence. Computer simulations of the proposed recurrent neuro-fuzzy control scheme and its performance comparison with some existing controllers have been conducted to validate the effectiveness of the proposed approach.
Nitric Oxide and Peroxynitrite Interactions with Mitochondria

Abstract Nitric oxide (NO) and peroxynitrite (ONOO) avidly interact with mitochondrial components, leading to a range of biological responses spanning from the modulation of mitochondrial respiration, mitochondrial dysfunction to the signaling of apoptotic cell death. Physiological levels of NO primarily interact with cytochrome c oxidase, leading to a competitive and reversible inhibition of mitochondrial oxygen uptake. In turn, this leads to alterations in electrochemical gradients, which affect calcium uptake and may regulate processes such as mitochondrial transition pore (MTP) opening and the release of proapoptotic proteins. Large or persistent levels of NO in mitochondria promote mitochondrial oxidant formation. Peroxynitrite formed either extra or intramitochondrially leads to oxidative damage, most notably at complexes I and II of the electron transport chain, ATPase, aconitase and Mnsuperoxide dismutase. Mitochondrial scavenging systems for peroxynitrite and peroxynitritederived radicals such as carbonate (CO3.) and nitrogen dioxide radicals (NO2) include cytochrome c oxidase, glutathione and ubiquinol and serve to partially attenuate the reactions of these oxidants with critical mitochondrial targets. Detection of nitrated mitochondrial proteins in vivo supports the concept that mitochondria constitute central loci of the toxic effects of excess reactive nitrogen species. In this review we will provide an overview of the biochemical mechanisms by which NO and ONOO regulate or alter mitochondrial functions.