Miracle-dz/UniFAR-FTUs huggingface dataset:
International Review of Biophysical Chemistry ( IREBIC ) Contents : Modeling Periodic and Aperiodic Behavior of Acetylcholine Hydrolysis

Recently developed approaches analyzing the degree of in-plane orientational ordering are compared. The first one originates from an intrinsic anisotropic shape of membrane constituents, based on which the mismatch curvature tensor M is introduced. The second one originates from the nematic tensor order parameter Q reflecting average local degree of orientational ordering. Based on these tensors free energy of systems are derived taking into account symmetry allowed combinations of tensors. From both approaches the degree of local orientational ordering is determined as a function of membrane shape. In the paper we discuss relevance of these approaches. Copyright © 2012 Praise Worthy Prize S.r. l. All rights reserved.
AT 1 receptor G q protein-independent signalling transcriptionally activates only a few genes directly , but robustly potentiates gene regulation from the β2 Adrenergic receptor

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. AT receptor Gαq protein-independent signalling transcriptionally activates only a few genes directly, but robustly potentiates gene regulation from the β-2Adrenergic receptor Gitte L. Christensen, Steen Knudsen, Mikael Schneider, Mark Aplin, Steen Gammeltoft, Søren P. Sheikh, Jakob L. Hansen
Tolerance and Immobilization of Cobalt by Some Bacteria from Ferromanganese Crusts of the Afanasiy Nikitin Seamounts

Bacteria isolated from cobalt–enriched ferromanganese crusts on the Afanasiy Nikitin Seamounts in the Equatorial Indian Ocean were examined for their ability to tolerate, and immobilize cobalt in unamended seawater and seawater amended with 0.01% glucose. Retrievable bacterial counts in the form of CFU (colony forming units) on media supplemented with 1 mmol Co l−1 (58 mg Co l−1) and 1 mmol Mn l−1 (54 mg Mn l−1) were in the range of 1.71 × 104 to 1.05 × 105 gm−1 (wet wt) of crust, respectively. Most of the isolates (14/24) were pigmented and showed taxonomic affinities to Flavobacterium sp. Two representative isolates were tested for their tolerance of cobalt. We observed that in amended medium, the isolates tolerated up to 1 mmol Co l−1, whereas in unamended medium they tolerated upto 10 mmol Co l−1. Microscopic observations of cultures incubated with 10 mmol Co l−1 showed the occurrence of an extracellular slime layer, which may be responsible for immobilizing the cobalt from the liquid phase. In the unamended medium, the tolerance and stimulation in total cell counts was similar to that in amended medium or sometimes greater. Total cell counts peaked at 100 μmol Co l−1 for incubations in unamended medium (1.1–2.5 × 1011 cells l−1) and at 0.1–1 μmol Co l−1 for incubations in amended medium (1.5–2.6 × 1011 cells l−1). Counts of formazan-stained respiring cells of both the isolates in the unamended medium reached up to a maximum of 2.9–7.8 × 1010 l−1 after incubation for 10 days at 23(±1)°. In the amended medium cell counts of respiring cells attained a maximum in the range of 4.6–15.8 × 1010 l−1 at 100 μmol Co l−1. The Co immobilization rate was on average 82 (± 87.9, n = 24) μmol of Co d−1. Since the isolates were naturally occurring bacteria from crusts, they could be more environmentally acceptable and safe if used for metal recovery and bio-leaching.
’ s repository of research publications and other research outputs It ROCS ! The RASH Online Conversion Service Conference or Workshop Item

In this poster paper we introduce the RASH Online Conversion Service, i.e., a Web application that allows the conversion of ODT documents into RASH, a HTML-based markup language for writing scholarly articles, and from RASH into LaTeX. This tool allows authors with no experience in HTML to easily produce HTML-based papers and supports the publishing process by generating also a LaTeX version according to the Springer LNCS and ACM ICPS layouts.
Bittner Biomolecular rods and tubes in nanotechnology

Biomolecules are vitally important elements in nanoscale science and also in future nanotechnology. Their shape and their chemical and physical functionality can give them a big advantage over inorganic and organic substances. While this becomes most obvious in proteins and peptides, with their complicated, but easily controlled chemistry, other biomolecular substances such as DNA, lipids and carbohydrates can also be important. In this review, the emphasis is on one-dimensional molecules and on molecules that self-assemble into linear structures, and on their potential applications. An important aspect is that biomolecules can act as templates, i.e. their shape and chemical properties can be employed to arrange inorganic substances – such as metals or metal compounds – on the nanometre scale. In particular, rodand tube-like nanostructures can show physical properties that are different from those of the bulk material, and thus these structures are likely to be a basis for new technology.
On centres and lax centres for promonoidal categories

Braidings for monoidal categories were introduced in [7] and its forerunners. The centre ZX of a monoidal categoryX was introduced in [6] in the process of proving that the free tortile monoidal category has another universal property. The centre of a monoidal category is a braided monoidal category. What we now call lax braidings were considered tangentially by Yetter [13]. What we now call the lax centre ZlX of X was considered under the name “weak centre” by P. Schauenburg [12]. The purpose of this work is to highlight the notions of lax braiding and lax centre for monoidal categories X and more generally for promonoidal categories C . Indeed we further generalize to the V -enriched context. Lax centres turn out to be lax braided monoidal categories. Generally the centre is a full subcategory of the lax centre, however it is sometimes the case that the two coincide. We have two such theorems under different hypotheses, one in the case sufficient dual objects exist in the additive context, and the other in the cartesian context. We examine when the centre of[C ,V ] with a convolution monoidal structure (in the sense of [1]) is again a functor category[D ,V ]. One reason for being interested in the lax centre of X is that, if an objectX of X is equipped with the structure of monoid in ZlX , then tensoring withX defines a monoidal endofunctor−⊗X of X ; this has applications in cases where the lax centre can be explicitly identified.
RECENT TRENDS IN OPHTHALMIC DRUG DELIVERY

The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Delivery of drugs to the targete d ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic drug levels are not maintained for lo nger duration in target tissues. To overcome the ocular drug delivery barriers and improve ocular bioavailabili ty, various conventional and novel drug delivery systems have been developed such as emulsion, ointments, suspensio ns, aqueous gels, nanomicelles, nanoparticles, liposomes, dendrimers, implants, contact lenses , nanosuspensions, microneedles and in situ the rmosensitive gels for the earlier mention ocular diseases.
Tested in Symptomatic Nondiabetic Patients Referred for Myocardial Perfusion

American Heart Association. All rights reserved. Print ISSN: 1942-325X. Online ISSN: 2013 Copyright © Avenue, Dallas, TX 72514 Circulation: Cardiovascular Genetics is published by the American Heart Association. 7272 Greenville DOI: 10.1161/CIRCGENETICS.112. 964015 2013;6;154-162; originally published online February 15, 2013; Circ Cardiovasc Genet Rosenberg Susan E. Daniels, Joseph A. Ladapo, Charles E. Phelps, Pamela S. Douglas and Steven Winn, Timothy M. Bateman, Michael R. Elashoff, Hsiao D. Lieu, Andrea M. Johnson, Gregory S. Thomas, Szilard Voros, John A. McPherson, Alexandra J. Lansky, Mary E. Imaging The COMPASS StudyClinical Perspective Tested in Symptomatic Nondiabetic Patients Referred for Myocardial Perfusion A Blood-Based Gene Expression Test for Obstructive Coronary Artery Disease http://circgenetics.ahajournals. org/content/6/2/154.full on the World Wide Web at: The online version of this article, along with updated information and services, is located . DC1.html http://circgenetics.ahajournals. org/content/suppl/2013/02/15/CIRCGENETICS.112. 964015 Data Supplement (unedited) at:
9 Indicators , sanitary surveys and source attribution techniques

Many epidemiological studies have linked exposure to contaminated surface waters with infection and disease (Cabelli et al. 1975, USEPA 1976, Cabelli 1978, Cabelli 1981, Cabelli 1982a, Cabelli et al. 1982b, Cabelli1983a, Cabelli et al. 1983b, Dufour 1984b, USEPA 1986, Dufour 1992, Prüss 1998, Bartram & Rees 2000a, Georgiou & Langford 2002, Kay et al. 2004). Chapter 11 of this book reviews four studies with a specific focus on water contaminated with animal waste. Worldwide, regulatory schemes for the protection of human health through classification of microbial quality of recreational waters differ in some
Textbook of Physiology

This 17th edition of what was originally Howell's textbook appears six years after its predecessor. Certain portions have been extensively modified and new chapters have been added, though the over-all length remains the same. The general outline and approach are unchanged, and the principal changes only will be considered here. Most sections have been brought carefully up to date. The reviewer missed the opening chapter of the older edition, a historical introduction by Dr. Fulton. The first seven chapters on neuronal mechanism have been slightly expanded, and considerable new material on electrical and metabolic interrelationships has been added. Later in the text is a fresh chapter on acetylcholine and energy transformation in nerve cells. It would seem that these might have been brought together. The section on muscle includes a welcome expansion of information on molecular mechanisms. The treatment of the central nervous system is notable for a new chapter on the limbic system with an excellent and recent bibliography. The section on sensation is little changed except for a new chapter, "Pathophysiology of Pain," and the inclusion of new experimental data on electroencephalography. The chapter on blood clotting, felt by the reviewer to have been a weak spot in the previous edition, has been well rewritten by a new author, Dr. Rosemary Biggs. Electrocardiography has been set off in a separate chapter and expanded to include data on body surface equipotentials. Respiratory regulation has been rewritten by Drs. Breckenridge and Hoff, on the basis of their own extensive investigations. Body fluids and the kidney have also received a new treatment under the editorship of Dr. William Blake. The high standard of writing and editing is maintained throughout. The bibliographies are longer and for the most part up to date, though the citations no longer include the titles of papers. The format has undergone only minor changes. The index appeared adequate when searched for topics in the reviewer's particular interests. W. P. MCNULTY, JR.
Event-Based High Dynamic Range Image and Very High Frame Rate Video Generation Using Conditional Generative Adversarial Networks

Event cameras have a lot of advantages over traditional cameras, such as low latency, high temporal resolution, and high dynamic range. However, since the outputs of event cameras are the sequences of asynchronous events over time rather than actual intensity images, existing algorithms could not be directly applied. Therefore, it is demanding to generate intensity images from events for other tasks. In this paper, we unlock the potential of event camera-based conditional generative adversarial networks to create images/videos from an adjustable portion of the event data stream. The stacks of space-time coordinates of events are used as inputs and the network is trained to reproduce images based on the spatio-temporal intensity changes. The usefulness of event cameras to generate high dynamic range (HDR) images even in extreme illumination conditions and also non blurred images under rapid motion is also shown. In addition, the possibility of generating very high frame rate videos is demonstrated, theoretically up to 1 million frames per second(FPS) since the temporal resolution of event cameras is about 1 microsecond. Proposed methods are evaluated by comparing the results with the intensity images captured on the same pixel grid-line of events using online available real datasets and synthetic datasets produced by the event camera simulator.
Grey-box modelling of an Unmanned Quadcopter during Aggressive Maneuvers

The treatment of quadcopter dynamics around steady-state conditions has often ignored some rotorcraft aerodynamic effects due to its complicated physical modeling or black-box estimated model. The identification of an unmanned quadcopter in accelerated flight using a grey-box modeling approach is investigated. The classical approach of using either first-principles modeling (white-box modeling) or pure observations modeling (black-box modeling) have limitations particularly for real-time applications. Radial basis functions neural networks (RBF-NN) were used to estimate the rotor dynamics parameters (motor PWM outputs) from an unknown flapping dynamics model. The identified models shows that a RBF-based grey-box modeling approach specifically in aggressive maneuvers, has benefits in both modeling accuracy, network size and robustness to noise.
The Development of Symbolic and Non-Symbolic Number Line Estimations: Three Developmental Accounts Contrasted Within Cross-Sectional and Longitudinal Data

Three theoretical accounts have been put forward for the development of children’s response patterns on number line estimation tasks: the log-to-linear representational shift, the two-linear-to-linear transformation and the proportion judgment account. These three accounts have not been contrasted, however, within one study, using one single criterion to determine which model provides the best fit. The present study contrasted these three accounts by examining first, second and sixth graders with a symbolic and non-symbolic number line estimation task (Experiment 1). In addition, first and second graders were tested again one year later (Experiment 2). In case of symbolic estimations, the proportion judgment account described the data best. Most young children’s non-symbolic estimation patterns were best described by a logarithmic model (within the log-to-lin account), whereas those of most older children were best described by the simple power model (within the proportion judgment account).
Depression affecting HIV people in two municipalities of Angola

Introducción: la depresión constituye un evento frecuente en las personas con VIH, de ahí que su estudio haya cobrado interés, entre los profesionales encargados de la atención a este segmento de la población. Objetivo: estimar la frecuencia de la depresión y su relación con factores sociodemográficos en personas con VIH/sida. Métodos: estudio descriptivo de corte transversal en 100 personas con VIH residentes en los municipios de Huambo y Bailundo, provincia de Huambo-Angola atendidas entre enero y mayo de 2012 y que cumplían con los criterios de inclusión. El estado depresivo se evaluó con el Inventario de Depresión de Beck y se aplicó una entrevista con preguntas cerradas. Resultados: hubo predominio del sexo femenino y la mayor parte de la población estudiada tenía bajo nivel de instrucción. Los síntomas depresivos de varias intensidades estuvieron presentes en 33 pacientes (33 %) de ambos sexos. Conclusiones: en la población estudiada la frecuencia de depresión fue relativamente baja con predominio de mujeres, personas jóvenes, con apoyo social y no asociada al empleo, al estado civil, ni a la escolaridad. Se recomienda el incremento de estudios en este contexto sociocultural considerando el impacto de la epidemia del VIH en esa parte del continente africano.
Serum miRNA–based Prediction of Axillary Lymph Node Metastasis in Breast Cancer

Purpose: Sentinel lymph node biopsy (SLNB) is the gold-standard procedure for evaluating axillary lymph node (ALN) status in patients with breast cancer. However, the morbidity of SLNB is not negligible, and the procedure is invasive for patients without ALN metastasis. Here, we developed a diagnostic model for evaluating ALN status using a combination of serum miRNAs and clinicopathologic factors as a novel less-invasive biomarker. Experimental Design: Preoperative serum samples were collected from patients who underwent surgery for primary breast cancer or breast benign diseases between 2008 and 2014. A total of 958 serum samples (921 cases of primary breast cancer, including 630 cases in the no ALN metastasis group and 291 cases in the ALN metastasis group, and 37 patients with benign breast diseases) were analyzed by miRNA microarray. Samples were randomly divided into training and test sets. Logistic LASSO regression analysis was used to construct diagnostic models in the training set, which were validated in the test set. Results: An optimal diagnostic model was identified using a combination of two miRNAs (miR-629-3p and miR-4710) and three clinicopathologic factors (T stage, lymphovascular invasion, and ultrasound findings), which showed a sensitivity of 0.88 (0.84–0.92), a specificity of 0.69 (0.61–0.76), an accuracy of 0.818, and an area under the receiver operating characteristic curve of 0.86 in the test set. Conclusions: Serum miRNA profiles may be useful for the diagnosis of ALN metastasis before surgery in a less-invasive manner than SLNB.
Arab American Cognitive Aging: Opportunities for Advancing Research on Alzheimer’s Disease Disparities

Abstract Background and Objectives This article highlights the dearth of and need for research on Arab American cognitive aging. We propose that studying cognitive health issues among older Arab Americans provides an innovative opportunity to advance knowledge about causes and consequences of Alzheimer’s disease (AD) disparities and refine understanding of factors linked to immigrant health in the United States. Research Design and Methods Demographic information is provided on Arab Americans, who are on the cusp of being recognized by the U.S. government as a distinct ethnic group separate from whites. In the tradition of minority aging, we present a broad review of specific issues in the contemporary case of Arab Americans. Results We detail how including Arab Americans provides unique information on the importance of: (i) extending racial/ethnic group comparisons; (ii) linking social experiences to late-life cognitive health; and (iii) incorporating ethnic factors related to immigration and religion in the study of AD disparities. Discussion and Implications Studying Arab American cognitive aging provides an innovative opportunity to more fully delineate factors that create and sustain health disparities, with special insights into both causes and consequences.
Social network plasticity decreases disease transmission in a eusocial insect

Protecting the colony When we get a cold and then stay home from work, we are not only taking care of ourselves but also protecting others. Such changes in behavior after infection are predicted in social animals but are difficult to quantify. Stroeymeyt et al. looked for such changes in the black garden ant and found that infected workers did alter their behavior—and healthy workers altered their behavior toward the sick. The changed behavior was especially valuable for protecting the most important and vulnerable members of the colony. Science, this issue p. 941 Sick black garden ants modify their behavior to protect the colony. Animal social networks are shaped by multiple selection pressures, including the need to ensure efficient communication and functioning while simultaneously limiting disease transmission. Social animals could potentially further reduce epidemic risk by altering their social networks in the presence of pathogens, yet there is currently no evidence for such pathogen-triggered responses. We tested this hypothesis experimentally in the ant Lasius niger using a combination of automated tracking, controlled pathogen exposure, transmission quantification, and temporally explicit simulations. Pathogen exposure induced behavioral changes in both exposed ants and their nestmates, which helped contain the disease by reinforcing key transmission-inhibitory properties of the colony’s contact network. This suggests that social network plasticity in response to pathogens is an effective strategy for mitigating the effects of disease in social groups.
ASH1-catalyzed H3K36 methylation drives gene repression and marks H3K27me2/3-competent chromatin

Methylation of histone H3 at lysine 36 (H3K36me), a widely-distributed chromatin mark, largely results from association of the lysine methyltransferase (KMT) SET-2 with RNA polymerase II (RNAPII), but most eukaryotes also have additional H3K36me KMTs that act independently of RNAPII. These include the orthologs of ASH1, which are conserved in animals, plants, and fungi but whose function and control are poorly understood. We found that Neurospora crassa has just two H3K36 KMTs, ASH1 and SET-2, and were able to explore the function and distribution of each enzyme independently. While H3K36me deposited by SET-2 marks active genes, inactive genes are modified by ASH1 and its activity is critical for their repression. ASH1-marked chromatin can be further modified by methylation of H3K27, and ASH1 catalytic activity modulates the accumulation of H3K27me2/3 both positively and negatively. These findings provide new insight into ASH1 function, H3K27me2/3 establishment, and repression in facultative heterochromatin.
A review of vedolizumab and ustekinumab for the treatment of inflammatory bowel diseases

Recent advancement in the understanding of the pathophysiology of inflammatory bowel disease has seen an expansion in therapeutic options. Vedolizumab, a selective α4β7 inhibitor, and ustekinumab, an IL 12/23 p40 inhibitor, have provided the much‐awaited out‐of‐class alternatives for patients who have failed or who are intolerant to anti‐Tumor Necrosis Factor (TNF) therapy. However, questions remain as to how we may best use these novel therapeutic agents. We evaluate the evidence available from randomized controlled trials and postmarketing cohort studies and discuss their safety, efficacy, and limitations, in relation to anti‐TNF therapy, in optimizing the treatment outcomes.