Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Rosuvastatin on the Renal Cortex of Adult Male Albino Rats and Possible Protective Effect of Co-enzyme Q 10 (Light and Electron Microscopic Study)

Abstract: Background: Rosuvastatin can decrease low-density lipoprotein cholesterol to the optimal goals. Adverse effects of rosuvastatin involve kidneys. Multiple studies explained that these side effects are due to reducing coenzyme Q10 levels. Objective: to throw light upon the histological changes in the renal cortex of albino rats treated with rosuvastatin and explore the impact of CoQ10 co-treatment. Methods: Forty adult albino rats were used in the study as follows: Group I: formed of 8 rats, given 1 ml distilled water/day for one month orally; Group II: formed of 8 rats, given 1.8 milligrams/Kilogram/day (CoQ10) for one month orally; Group III: formed of 8 rats, given 0.72 milligrams/Kilogram/day rosuvastatin for one month orally; Group IV: formed of 8 rats, given 0.72 milligrams/Kilogram/day rosuvastatin and 1.8 milligrams/Kilogram/day CoQ10 for one month orally; Group V: formed of 8 rats, received the same dose of rosuvastatin as in group III then the rats were sacrificed two weeks later. Results: In group III, there were severe histo-pathological changes in the renal corpuscles and tubules. Also, the biochemical results (serum urea and creatinine) were deteriorated. In group V and IV, the biochemical results were improved significantly. The histological integrity of the renal cortex was returned to normal. Conclusion: This study revealed that CoQ10 played a protective role against rosuvastatin nephrotoxicity.
Current knowledge, status, and future for plant and fungal diversity in Great Britain and the UK Overseas Territories

Colin Clubbe1 | A. Martyn Ainsworth2 | Sara Bárrios1 | Keith Bensusan3 | Juliet Brodie4 | Paul Cannon2 | Ted Chapman5 | Alison I. Copeland6 | Marcella Corcoran1 | Michele Dani Sanchez1 | John C. David7 | Trevor Dines8 | Lauren M. Gardiner9 | Martin A. Hamilton1 | Thomas Heller1 | Peter M. Hollingsworth10 | Nicola Hutchinson8 | Theo Llewelyn11,12 | Laura Lowe Forrest10 | Kevin J. McGinn13 | Stephanie Miles5 | Katherine O'Donnell14 | Nancy Woodfield-Pascoe15 | Tim C. G. Rich16 | Fred Rumsey4 | Jolene Sim17 | Struan R. Smith18 | Nicola Spence19 | Andrew Stanworth20 | Peter Stroh21 | Ian Taylor22 | Clare Trivedi5,23 | Alex D. Twyford10,24 | Juan Viruel1 | Kevin Walker25 | Jo Wilbraham4 | Julian Woodman26 | Michael F. Fay1,27
Spatial and temporal control of norovirus protease activity is determined by polyprotein processing and intermolecular interactions within the viral replication complex

Norovirus infections are a major cause of acute viral gastroenteritis and a significant burden to human health globally. A vital process for norovirus replication is the processing of the nonstructural polyprotein, by an internal protease, into the necessary viral components required to form the viral replication complex. This cleavage occurs at different rates resulting in the accumulation of stable precursor forms. In this report, we characterized how precursor forms of the norovirus protease accumulate during infection. Using stable forms of the protease precursors we demonstrated that these are all proteolytically active in vitro, but that when expressed in cells, activity is determined by both substrate and protease localization. Whilst all precursors could cleave a replication complex-associated substrate, only a subset of precursors lacking NS4 were capable of efficiently cleaving a cytoplasmic substrate. For the first time, the full range of protein-protein interactions between murine and human norovirus proteins were mapped by LUMIER assay, with conserved interactions between replication complex members, modifying the localization of a subset of precursors. Finally, we demonstrate that re-targeting of a poorly cleaved artificial cytoplasmic substrate to the replication complex is sufficient to permit efficient cleavage in the context of norovirus infection. This offers a model for how norovirus can regulate the timing of substrate cleavage throughout the replication cycle. The norovirus protease represents a key target in the search for effective antiviral treatments for norovirus infection. An improved understanding of protease function and regulation, as well as identification of interactions between the other non-structural proteins, offers new avenues for antiviral drug design.
Magnetic Particle Imaging for intraoperative margin analysis in breast-conserving surgery

Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has high reexcision rates due to post-surgery identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively has been shown to reduce the need for additional surgeries, and while many techniques have been explored, the clinical need is still unmet. We assess Magnetic Particle Imaging (MPI) for intraoperative margin assessment in BCS, using a passively or actively tumor-targeted iron oxide agent and two hardware devices: a hand-held Magnetic Particle (MP) detector for identifying residual tumor in the breast, and a small-bore imager for quickly imaging the tumor distribution in the excised specimen. In this abstract, we present both hardware systems and demonstrate proof-of-concept detection and imaging of clinically-relevant phantoms.
Simultaneous Imaging of Magnetic Nanoparticle Concentration, Temperature, and Viscosity

A new approach of simultaneous imaging of magnetic nanoparticle (MNP) concentration, temperature and viscosity with a custom-built scanning magnetic particle spectrometer (SMPS) is presented. The fundamental f0 and the 3f0 and 5f0 harmonics of the MNPs dominated by Brownian relaxation are measured with the SMPS. The effects of viscosity and temperature on the harmonics are studied in ac magnetic fields with different frequencies and amplitudes. Afterwards, phantom experiments are performed on the MNP samples with different spatial distributions of viscosity and temperature, which demonstrates the feasibility of the proposed approach for simultaneous imaging of MNP concentration, temperature and viscosity imaging.
Identification and Characterization of the Dominant Lactic acid Bacteria Isolated from Traditional Fermented Milk

Five samples of Airag and 20 of Tarag (both in Mongolia) were collected from scattered households. One hundred strains of lactic acid bacteria (LAB) were isolated and identified from these sam- ples according to phenotypic characterization and 16S rRNA gene sequence analysis. Eighty-five isolates belonged to the genus Lactobacillus, 15 being classified as coccoid LAB. All isolates belonged to 5 genera and 11 to different species and subspecies. Lactobacillus (Lb.) helveticus was predominant population in Airag samples, Lb. fermentum and Lb. helveticus were the major LAB microflora in Tarag.
Biofilms of Salmonella and Campylobacter in the Poultry Industry

Biofilm is characterized by a bacterial population firmly adhered to a surface involved by a self-produced matrix of extracellular polymeric substance. These communities provide longer survival and resistance to adverse conditions such as presence of antibiotics and disinfectants. Various foodborne microorganisms are capable of forming such structures, including Salmonella and Campylobacter, which are the major contaminants at the poultry industry. This biomass can affect the water transport system and pipes, and once the agent is established at the industry, it can form biofilms in any processing area. There are intrinsic and extrinsic mechanisms, and also molecular aspects involved in the biofilm formation. The adoption of several strategies may exhibit effectiveness to prevent the cell adhesion, such as the use of surfaces resistant to biofilm formation. In case of preexisting biofilms, there are physical, chemical, and biological methods used to control and eliminate them. Nanotechnology has emerged as another effective measure as nanometals affect the essential activities of microorganisms. These findings highlight the difficulty in controlling biofilms, due to the strategies used by these agents to adapt and survive in sessile form, causing recurring contamination throughout the poultry chain production, deterioration in the final product and infections in the human host.
Professional Development in training and Tutoring Have I really gained experience and skill through training and tutoring sessions? Case of: a special third year student, language sciences and didactics (SLD), Department of English, University of Bejaia

Practitioner engagement is not an easy task in teaching in higher education. In fact, there is much evidence now to propose a strong relationship between active engagement and the quality of the teaching experience. But what exactly do we mean by ‘engagement’? For many it simply refers to assisting students to connect with the subject material in a way that generates interest, enjoyment and interaction. Generating active participation is particularly important in tutorials or small group teaching, where tutorials ‘by design’, are intended to provide students a different kind of learning experience than the lecture. It is also through active engagement that both, teachers and students take greater ownership for their teaching craft and learning process. This concept assists in the development of an overall design or structure to support such engagement and active participation. The more organized and clear the teachers and students are, the more likely it is that they will get the desired and target results. In addition to this, active engagement of teachers should be reinforced by a reflective practice which is an active process too of attending to their own experience of teaching in order to explore it in some depth. It is in fact a ‘dialogue of thinking and doing through which teachers become more skilled. This process develops by thinking critically and deeply about what teachers are doing in order that they may transform that experience and reapply it in new contexts. In many respects, Professional Development in training and tutoring has been designed to motivate reflection on one’s teaching practice and mostly where teachers have an opportunity to see others in practice. The article’s results have been derived from the interpretation of the data collected through designing an interview addressed to the only special student of the department and show the researcher’s experience as a teacher and an administrator with Abdenour, this is how I like to call him, a blind student, but his determination and willingness to succeed in his higher studies made of him a remarkable young man. Special tutoring and training sessions have been designed to enable him fully integrate the learning community. Therefore, this article has been directed to focalize on the pedagogical decisions based on implementing and considering the training and tutoring sessions as a necessity to develop first the teaching craft and then help, advise and guide our students towards more success in their studies. Is not it mentioned in the official document (Journal officiel de la République Algérienne N°23 du 4 Mai, 2008 ; articles 33,34, 35, …) « to receive the students 3 hours/week to advise and orient them »?
Signature Pedagogies: A Framework for Pedagogical Foundations in Counselor Education

Twenty years ago, in a special section of Counselor Education and Supervision (CES), Thomas Sexton (1998) identified a lack of research on the fundamental pedagogical assumptions used in counselor education to prepare counselors and counselor educators. Specifically, he noted that the manner in which counseling content was delivered and the use of developmental and theoretical models to guide teaching efforts in counselor education had “largely gone unexplored” (Sexton, 1998, p. 66). In fact, Nelson and Neufeldt (1998) were unable to find any scholarly articles on pedagogy in the counseling literature, which was justifiably concerning. Fortunately, there is now some evidence in the counselor education literature addressing this concern (e.g., Association for Counselor Education and Supervision [ACES], 2016; Barrio Minton et al., 2014). Recently, Barrio Minton et al. (2018) found a sharp increase in empirical articles in counselor education articles between 2001–2010 and 2011–2015 incorporating pedagogical foundations, potentially due to the expansion of doctoral-level teaching and learning curricula and internships required by the 2016 Council for Accreditation of Counseling and Related Education Program (CACREP) Standards (2015). Korcuska (2016) cautioned that simply grounding the rationale for pedagogy studies in the CACREP standards could lead authors to overlook the underlying pedagogical structures and lead to studies without “heft or staying power” (p. 156). It is plausible to presume that it is uncertain if, as a profession, we are asking the “right” questions, and studying the “best” things to increase our collective understanding of the pedagogical foundations in counselor education. Overall, both Korcuska and Barrio Minton and colleagues (2014) recommended that more research be conducted on the processes (i.e., pedagogy) for preparing teachers in counselor education, and examining the links between pedagogy, effectiveness in the classroom, and preparing students for professional practice.
Seasonal Wounding and Resin-cyst Production in the Hemlock, Tsuga canadensis (L.) Carr

THE of certain production conifers, of resin and tissue in some in response groups, to such wounding as the is Abieteae, characteristic the of certain conifers, and in some groups, such as the Abieteae, th relationship is more evident than in others. To determine the character of this response to wounding at different seasons of the year, studies were made with Tsuga canadensis , a member of this group. The preliminary work of wounding was done by Professors R. B. Thomson and H. B. Sifton, who handed the material over to the writer for detailed examination. Branches of similar size occupying the same relative positions on the lower parts of old trees were selected, and wounded throughout the year with shorter intervals during the growing season. Half-round and ^-inch chisels were used. Usually two, in some cases more, branches were wounded on each date, one with each chisel. Six to eight wounds, spaced at intervals of 23 cm. , were made on the upper side of each branch. For each wound two contiguous cuts were made, so that an elliptical area of bark and cambium with a minor diameter of | or & inches and a slightly greater major diameter (lengthwise of the branch) was removed. Four stems of young trees were also wounded. After one or two years the wounded material was collected.
The European Turtle-Dove Streptopelia turtur in Northwest Africa: A Review of Current Knowledge and Priorities for Future Research

Summary. In recent decades, a general decline in Palearctic-African migrant birds has been recorded over large areas of the Palearctic. The European Turtle-dove Streptopelia turtur has undergone a rapid and serious decline across its European range, to the extent that it was categorised as Vulnerable on the IUCN Red List in 2015. In this review, I synthesise the scientific literature currently available on the Turtle-dove in North Africa S. t. arenicola. I also discuss current knowledge, highlight gaps in data and outline high-priority research guidelines, while attempting to direct research efforts more effectively and to encourage appropriate and sustainable management strategies. Priorities for future research are concentrated in five key areas: (i) demography, (ii) migration, (iii) ecology, (iv) genetics, and (v) parasites and diseases. Setting up an integrated programme of long-term ecological monitoring in North African farmland and woodlands, as well as integrating new technologies into monitoring programmes, is an urgent need. These programmes should be standardised in all countries along the migratory flyway to produce comparable data. Scientific collaboration among research institutions, on national, regional and international scales, should be coordinated for maximum efficacy of the monitoring and research programmes.
Construal Matching in Online Search: Applying Text Analysis to Illuminate the Consumer Decision Journey

As consumers move through their decision journey, they adopt different goals (e.g., transactional vs. informational). In this research, the authors propose that consumer goals can be detected through textual analysis of online search queries and that both marketers and consumers can benefit when paid search results and advertisements match consumer search–related goals. In bridging construal level theory and textual analysis, the authors show that consumers at different stages of the decision journey tend to assume different levels of mental construal, or mindsets (i.e., abstract vs. concrete). They find evidence of a fluency-driven matching effect in online search such that when consumer mindsets are more abstract (more concrete), consumers generate textual search queries that use more abstract (more concrete) language. Furthermore, they are more likely to click on search engine results and ad content that matches their mindset, thereby experiencing more search satisfaction and perceiving greater goal progress. Six empirical studies, including a pilot study, a survey, three lab experiments, and a field experiment involving over 128,000 ad impressions provide support for this construal matching effect in online search.
Progression of Ash Dieback in Norway Related to Tree Age, Disease History and Regional Aspects

Ash dieback, caused by the ascomycete Hymenoscyphus fraxineus, has been spreading throughout Europe since the early 1990s, threatening European ash at a continental scale. Little is known about the development of the disease in individual forest trees and in different age classes. In this study we monitored ash dieback on trees of different diameter classes in five permanent plots in ash stands in south-eastern Norway from 2009 to 2016, and from 2012 to 2016 in three plots in western Norway with a shorter disease history. Our results showed that more than 80% of the youngest and more than 40% of the intermediate future crop trees in the plots in south-eastern Norway were dead by 2016, while the disease development in large, dominant trees was slower. Although less damage has been observed in the plots in western Norway, the trend for the juvenile trees is the same as in south-eastern Norway with rapidly increasing damage and mortality. Most dead trees in south-eastern Norway were found at sites with high soil moisture and showed symptoms of root-rot caused by Armillaria species. Infected trees, both young and old ones, are weakened by the disease and appear to be more susceptible to other, secondary pathogens, especially under unfavourable site conditions.
Metabolomanalyse von Corynebacterium glutamicum und Pseudomonas aeruginosa unter verschiedenen Wachstumsbedingungen

Metabolomanalyse mittels GC-MS ist eine hochsensitive Methode der Charakterisierung des Phanotyps. Sie kann Veranderungen im zellularen Zustand aufgrund genetischer oder umweltbedingter Einflusse aufdecken und findet Anwendung fur detaillierte Vergleiche eines Wirtes mit einem Pathogen oder fur die Stammoptimierung in industriellen Prozessen. C. glutamicum wurde in einer Prozess-kontrollierten batch-Fermentation auf den Kohlenstoffquellen Glucose und Quinat kultiviert. Die intrazellularen Konzentrationen konnten in distinkte Cluster eingeteilt und anschliesend verglichen werden. Dabei zeigten sich deutliche Unterschiede in dem metabolischen Zustand beider Fermentationen, was Ruckschlusse auf aktive Stoffwechselwege, wie den β-Ketoadipatweg sowie den Glyoxylatweg unter Verwendung von Quinat als Kohlenstoffquelle, zulasst. Zusatzlich konnte die reversible Bildung eines roten Farbstoffes wahrend eines Sauerstoff-limitierten Fermentationsprozesses mit der Kohlenstoffquelle Quinat beobachtet werden. Auserdem wurde der Wachstumsphanotyp und das Metabolom der P. aeruginosa-Stamme PAO1, PA14, TBCF10839, der Transposonmutanten D8A6, PA1436, PA1572, PA5349, PA4640 sowie von drei klinischen Isolaten von je zwei Cystische Fibrose-Patienten auf unterschiedlichen Kohlenstoffquellen detaillierter charakterisiert. Der Metabolismus der P. aerugionsa-Stamme PAO1, PA14 sowie TBCF10839 wird durch das Wachstumssubstrat und nicht durch den stammspezifischen Hintergrund definiert. Bei der Untersuchung der Transposonmutanten verglichen mit dem Referenzstamm TBCF10839 resultierten deutliche Unterschiede in Bezug auf das Wachstum und den metabolischen Zustand. Die Analyse der klinischer Isolate gewahrt Einblicke in die Adaptationsprozesse an den Respirationstrakt von CF-Patienten. Ferner konnte die Extraktionsmethode fur die Phasenseparation hydrophober Metabolite fur P. aeruginosa etabliert werden, wobei zwei der drei dominierenden Cyclopropane in bakteriellen Membranlipiden detektiert wurden.
The Psychological Decision-Making Process Model of Giving up Driving under Parking Constraints from the Perspective of Sustainable Traffic

Parking restrictions can affect the use of cars and become an effective means to promote the sustainable development of urban traffic. To understand the influencing factors of car owners giving up driving due to parking constraints, the research constructs a theoretical model of psychological decision process about giving up driving under parking constraints, based on the Theory of Planned Behavior (TPB), and taking the public transit perception as a mediating variable, considering psychological factors. The empirical data were used to verify and modify the model by the Structural Equation Model (SEM) method, and finally the model was determined. The result shows that the choice of travel mode under the constraint of parking berth is not only affected by individual social and economic attributes and travel mode characteristics, but also by psychological latent variables such as behavioral attitude, subjective norms, perceived behavior control, public transportation perception and behavior intention. The subjective norms of car owners about giving up driving have a positive effect on perceived behavioral control and behavioral attitude; perceived behavior control also has an effect on behavior attitude; the behavior attitudes, subjective norms and perceived behavior control all have positive effects on the behavior intention of giving up driving due to parking constraints, among which public transit perception plays a positive adjustable intermediary role. The Integration of Choice and Latent Variable (ICLV) model considering psychological latent variables has a higher fitting degree to empirical data than the traditional Multinomial Logit (MNL) model. Based on the analysis results, some suggestions for auxiliary measures to implement the optimization strategy of parking supply are put forward.
Genetic analysis of RNA polymerase I unveils new role of the Rpal2 subunit during transcription

Most transcriptional activity of exponentially growing cells is carried out by RNA Polymerase I (Pol I), which produces a large rRNA precursor. The Pol I transcription cycle is achieved through complex structural rearrangements of the enzyme, revealed by recent structural studies. In the yeast S. cerevisiae the Pol 1 subunit Rpa49, particularly its C-terminal tandem winged helix domain (Rpa49Ct), is required supports both initiation and elongation of the transcription cycle. Here, we characterized novel extragenic suppressors of the growth defect caused by the absence of Rpa49. We identified suppressor mutations on the two largest subunits of Pol I, Rpa190 and Rpa135, as well as Rpa12. Suppressor mutants RPA135-F301S and RPA12-S6L restored normal rRNA synthesis and increased Pol I density on rDNA genes in the absence of Rpa49Ct. Most mutated residues cluster at an interface formed by the jaw in Rpa190, the lobe in Rpa135, and subunit Rpa12 when mapped on the structure of Pol I. Our genetic data in S. cerevisiae suggest a new role for Rpa12 at the jaw/lobe interface during transcription cycle.