Miracle-dz/UniFAR-FTUs huggingface dataset:
Successful Treatment of Catastrophic Antiphospholipid Antibody Syndrome (CAPS) Associated With Splenic Marginal-zone Lymphoma With Low-molecular Weight Heparin, Rituximab and Bendamustine

Case report:A 69-year-old woman with splenic marginal-zone lymphoma was admitted with progressive abdominal pain and splenomegaly as the suspected cause of pain. Rituximab treatment (375 mg/m2) had been initiated on the day of admission. Abdominal computerized tomography revealed splenic infarction. Laboratory tests showed elevation of liver enzymes and creatinine, low platelet count, prolonged partial thromboplastin time, and lupus anticoagulant positivity. The diagnosis of catastrophic antiphospholipid antibody syndrome was made. Weight-adjusted low-molecular weight heparin therapy was initiated. Freedom from symptoms and normalization of liver enzymes and creatinine occurred within 4 weeks. Treatment was continued with 6 cycles of bendamustine monotherapy (90 mg/m2) and heparin, leading to partial remission of lymphoma and lupus anticoagulant negativity. Conclusions:In case of multiorgan failure in patients suffering from lymphoma and showing features of disseminated intravascular coagulation, catastrophic antiphospholipid antibody syndrome should be considered. In our patient, rituximab followed by weight-adjusted low-molecular weight heparin and bendamustine therapy led to recovery.
Impact of organizational justice on learning organization: An empirical investigation of banking sector of Pakistan

The primary purpose of this research is to examine the association between learning organization and organizational justice in the banking sector of Pakistan. This research also investigates that which type of organizational justice is more effective in banking sector of Pakistan. The findings of this paper show that organizational justice has a significant impact on learning organization. Furthermore, it is also found that distributive justice is more effective than other dimensions of justice.
Natural history of neurofibromatosis 1–associated optic nerve glioma in mice

Children affected with the inherited tumor predisposition syndrome, neurofibromatosis 1 (NF1), are prone to the development of low‐grade astrocytic optic pathway tumors (optic pathway glioma [OPG]). Previously, we developed a model of NF1‐associated astrocytoma (GFAPCre; Nf1flox/mut mice) in which mice develop optic nerve and chiasm glioma. To define the molecular pathogenesis of OPG, we used this mouse model to study the natural history of OPG formation using immunohistological and radiographic approaches. We observed that whereas astrocyte hyperplasia is present in the optic nerves associated with gross optic nerve thickening at 3 weeks of age, overt neoplastic changes were not seen until 2 months of age. Astrocyte proliferation was maximal between 3 weeks and 2 months of age, suggesting that the most rapid period of growth occurs early. Mouse OPG tumors were detected by magnetic resonance imaging at 2 months of age and exhibited contrast enhancement, as seen in human OPG. In addition, the mouse OPG tumors exhibited expression of proteins associated with astroglial progenitors, including nestin and brain lipid binding protein. Last, we observed neovascularization and microglial cell infiltration by 3 weeks of age before overt neoplastic transformation, suggesting that these cellular changes participate in the early stages of tumor formation. Ann Neurol 2005;57:119–127
Effect of therapeutic exercise on gait speed in community-dwelling elderly people: a meta-analysis.

BACKGROUND AND PURPOSE Inconsistent research findings make it unclear whether therapeutic exercise improves gait speed in community-dwelling elderly people. Using meta-analytical procedures, we examined the effect of therapeutic exercise on changing gait speed in community-dwelling older adults and the effect of type, intensity, and dose of therapeutic exercise on gait speed. METHOD Studies were retrieved using a comprehensive database search. Two independent reviewers determined study eligibility based on inclusion criteria, rated study quality, and extracted information on study methods, design, intervention, and results. Data were combined to obtain an overall effect size, its 95% confidence interval, and a measure of significance. In addition, analyses to characterize the clinical relevance of the findings were performed. RESULTS One hundred seventeen studies were evaluated, with 24 studies (n=1,302 subjects) meeting the inclusion criteria for habitual gait speed and 18 studies (n=752 subjects) meeting the inclusion criteria for fast gait speed. Therapeutic exercise--or, more specifically, strength training and combination training (aerobic plus other exercise)--had significant effects (r=.145, P=.017; r=.176, P=.002, respectively) on habitual gait speed. High-intensity (effort expended by subjects) exercise and high-dosage (frequency and duration of exercise sessions) intervention also had a significant effect (r=.184, P=.001; r=.190, P=.001, respectively) on gait speed, whereas there was no effect for moderate- and low-intensity exercise or for low-dosage exercise. No exercise intervention affected fast gait speed in this analysis. DISCUSSION AND CONCLUSION The results provide support for the belief that therapeutic exercise can improve gait speed in community-dwelling elderly people and that intensity and dosage are important contributing factors. The relatively weak correlation found between therapeutic exercise and gait speed merits further study.
To what extent do European tourist guide-training curricula include sustainability principles?

ABSTRACT The present study examines the extent to which the topics of sustainability – considered innovative subjects in guiding – are included in guide training programmes in eight European countries. To the best of our knowledge, this is the first study of its kind in Europe. It is assumed that tourist guides have the unique opportunity to improve visitors’ knowledge, understanding and appreciation of a destination and thus contribute to sustainability. Data were collected from training institutions in Belgium, France, Hungary, Italy, Malta, the Netherlands, Norway and Spain, all participants of INNOGUIDE, a European Union-sponsored project. Analyses were conducted based on the programmes’ documentation and curricula. The programmes vary widely in their content. The issues of sustainability are not sufficiently integrated in tourist guide training programmes. There might be room for improvements of how tourist guides may contribute to visitors’ understanding of sustainability issues, both in the place visited and in general. Future research should replicate the present study employing more detailed investigation and larger samples, as well as study how tourist guide training is structured. Managerial consequences include improvements in guides’ training programmes; additional contributions of the study include criteria and indicators that may be applied in developing or improving such programmes.
GmPep914, an Eight-Amino Acid Peptide Isolated from Soybean Leaves, Activates Defense-Related Genes1[W][OA]

Only a handful of endogenous peptide defense signals have been isolated from plants. Herein, we report a novel peptide from soybean (Glycine max) leaves that is capable of alkalinizing the media of soybean suspension cells, a response that is generally associated with defense peptides. The peptide, DHPRGGNY, was synthesized and found to be active at 0.25 nm and requiring only 5 to 10 min to obtain a maximal pH change. The peptide is located on the carboxy-terminal end of a 52-amino acid precursor protein (Glyma12g00990) deduced from the soybean genome project. A search of the soybean databank revealed a homolog (Glyma09g36370) that contained a similar peptide, DLPRGGNY, which was synthesized and shown to have identical activity. The peptides, designated GmPep914 (DHPRGGNY) and GmPep890 (DLPRGGNY), were capable of inducing the expression of both Glyma12g00990 (GmPROPEP914) and Glyma09g36370 (GmPROPEP890) in cultured soybean suspension cells within 1 h. Both peptides induced the expression of defense genes, including CYP93A1, a cytochrome P450 gene involved in phytoalexin synthesis, chitinaseb1-1, a chitinase involved in pathogen defense, and Glycine max chalcone synthase1 (Gmachs1), chalcone synthase, involved in phytoalexin production. Both GmPROPEP914 and GmPROPEP890 were highly expressed in the roots, relative to the aerial portions of the plant. However, treatment of the aerial portion of soybean plants with hormones involved in elicitation of defense responses revealed a significant increase in expression levels of GmPROPEP914 and GmPROPEP890. A search of gene databases revealed homologous sequences in other members of the Fabales and also in the closely related Cucurbitales but not in any other order of plants.
Occupational Employment Projections to 2022

Total employment in the U.S. economy is projected to grow by 15.6 million during the 2012–2022 decade to reach 161 million; this represents a 10.8-percent employment increase. Some of the fastest projected growth will occur in the healthcare, healthcare support, construction, and personal care fields. Together, these four occupational groups are expected to account for about one-third—more than 5.3 million—of all new jobs during this period.
Outcomes of mental health care for children and adolescents: I. A comprehensive conceptual model.

OBJECTIVE Accountability for mental health care has become a standard of clinical practice. With the expansion of managed care as a corporate response to health reform, attention to outcomes will intensity. Assessment of clinical treatment has typically focused on symptom reduction at an individual level, whereas assessment of service effectiveness has more often targeted service-level change. METHOD A dynamic and interactional model of outcomes is presented that broadens the range of intended consequences of care. The model comprises five domains: symptoms, functioning, consumer perspectives, environmental contexts, and systems. RESULTS The model reflects the changeable interaction between children's evolving capacities and their primary environments (home, school, and community). CONCLUSIONS As health care practices shift, attention to improved care is likely to depend increasingly on scientifically credible evidence of its impact. Greater integration between research and standard practice will be needed. Such a partnership can be strengthened by a more comprehensive view of the impact of care.
Preprotachykinin-A Gene Products Are Key Mediators of Lung Injury in Polymicrobial Sepsis1

Preprotachykinin-A (PPT-A) gene products substance P and neurokinin-A have been shown to play an important role in neurogenic inflammation. To investigate the role of PPT-A gene products in lung injury in sepsis, polymicrobial sepsis was induced by cecal ligation and puncture in PPT-A gene-deficient mice (PPT-A−/−) and the wild-type control mice (PPT-A+/+). PPT-A gene deletion significantly protected against mortality, delayed the onset of lethality, and improved the long-term survival following cecal ligation and puncture-induced sepsis. PPT-A−/− mice also had significantly attenuated inflammation and damage in the lungs. The data suggest that deletion of the PPT-A gene may have contributed to the disruption in recruitment of inflammatory cells resulting in protection against tissue damage, as in these mice the sepsis-associated increase in chemokine levels is significantly attenuated.
Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell

Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix (ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent crosslinkages which stabilize these fibrous proteins. Its catalytic activity depends upon both its copper cofactor and a unique carbonyl cofactor and has been shown to extend to a variety of basic globular proteins, including histone H1. Although the three‐dimensional structure of LO has yet to be determined, the present treatise offers hypotheses based upon its primary sequence, which may underlie the prominent electrostatic component of its unusual substrate specificity as well as the catalysis‐suppressing function of the propeptide domain of prolysyl oxidase. Recent studies have demonstrated that LO appears to function within the cell in a manner, which strongly modifies cellular activity. Newly discovered LO‐like proteins also likely play unique roles in biology. © 2002 Wiley‐Liss, Inc.
Fas–670 promoter polymorphism is associated to susceptibility, clinical presentation, and survival in adult T cell leukemia

Fas (TNFRSF6/Apo‐1/CD95) is a type I transmembrane receptor, which mediates apoptosis. Fas gene mutations, aberrant transcripts, and abundant expression of Fas have been reported in adult T cell leukemia (ATL). To further elucidate the role of Fas in ATL pathogenesis, we investigated whether the –670 FAS promoter A/G polymorphism (STAT1‐binding site) might contribute to susceptibility and clinical outcome in ATL. Thirty‐one patients with ATL, 33 healthy, human T lymphotropic virus type 1‐infected individuals, and 70 healthy, uninfected controls were genotyped for the FAS –670 polymorphism by PCR‐restriction fragment‐length polymorphism. The AA genotype was significantly over‐represented in ATL patients in comparison with healthy controls (P=0.006), as well as asymptomatics (P=0.037), corresponding to an odds ratio (OR) of 3.79 [95% confidence intervals (CI; 1.28–11.41)] and 4.58 [95% CI (1.13–20.03)], respectively. The AA group also comprised significantly more aggressive (acute and lymphoma) clinical subtypes [P=0.012; OR=8.40; 95% CI (1.60–44.12)]. In addition, we observed a statistically significant association between GG genotype and survival (log rank test, P=0.032). Finally, IFN‐γ‐induced but not basal FAS mRNA levels were increased significantly (P=0.049) in PBMCs from AA versus GG individuals, demonstrating the IFN‐dependent functionality of the –670 polymorphism. In conclusion, our results demonstrate that a functional Fas promoter polymorphism is significantly associated to susceptibility, clinical manifestation, and survival in ATL.
Big data science for predicting insurance claims fraud

The cost of insurance is on the rise globally with contributing factors being new legislation and fraud. Both of these factors are problematic with new legislation not easily controllable by insurance companies and fraud very difficult to proactively detect. Hence, controlling the upward trend of cost is problematic. We therefore investigate the use of Big Data and Data Science (Big Data Science) to predict insurance claims fraud. Big Data, Data Science and Predictive Analytics were applied to the shortterm insurance industry with a use-case in the developing world. This study was performed within the bounds of the constraints of privacy legislation that invokes standards on how data can be kept and shared — we suggest a privacy preservation method of predicting insurance claims fraud.
The Concept of Access: Definition and Relationship to Consumer Satisfaction

Access is an important concept in health policy and health services research, yet it is one which has not been defined or employed precisely. To some authors “access” refers to entry into or use of the health care system, while to others it characterizes factors influencing entry or use. The purpose of this article is to propose a taxonomic definition of “access. ” Access is presented here. as a general concept that summarizes a set of more specific dimensions describing the fit between the patient and the health care system. The specific dimensions are availability, accessibility, accommodation, affordability and acceptability. Using interview data on patient satisfaction, the discriminant validity of these dimensions is investigated. Results provide strong support for the view that differentiation does exist among the five areas and that the measures do relate to the phenomena with which they are identified.
Information Security Continuous Monitoring (ISCM) for Federal Information Systems and Organizations: National Institute of Standards and Technology Special Publication 800-137

The purpose of the National Institute of Standards and Technology Special Publication 800-137 Information Security Continuous Monitoring (ISCM) for Federal Information Systems and Organizations guideline is to assist organizations in the development of a continuous monitoring strategy and the implementation of a continuous monitoring program providing visibility into organizational assets, awareness of threats and vulnerabilities, and visibility into the effectiveness of deployed security controls. It provides ongoing assurance that planned and implemented security controls are aligned with organizational risk tolerance as well as the information needed to respond to risk in a timely manner should observations indicate that the security controls are inadequate. ~
Comparison of Antibody Titers Determined by Hemagglutination Inhibition and Enzyme Immunoassay for JC Virus and BK Virus

ABSTRACT A comparison of antibody titers to JC virus (JCV) or BK virus (BKV) was made by hemagglutination inhibition (HI) and enzyme immunoassay (EIA) with 114 human plasma samples. Antibody titers to JCV or BKV determined by HI were lower than those determined by EIA. Nevertheless, as HI titers increased so did EIA titers. When antibody data were compared by the Spearman rank correlation test, highly significant correlations were found between HI and EIA titers. Results obtained by plotting EIA antibody titers for JCV against those for BKV generally showed a reciprocal relationship, i.e., samples with high antibody titers to JCV had lower antibody titers to BKV and vice versa. Some samples, however, had antibody titers to both viruses. Of the samples tested, 25.4% (25 of 114) had HI and EIA antibody titers to JCV and BKV which were identical or closely related. This is not the scenario one would expect for cross-reactive epitopes shared by the two viruses, but one suggesting that these samples were from individuals who had experienced infections by both viruses. Adsorption with concentrated JCV or BKV antigen of sera with high antibody titers to both JCV and BKV and testing by JCV and BKV EIA gave results which support this conclusion. Although 52.6% (51 of 97) of the samples from the Japanese population tested had very high antibody titers (≥40,960) to either JCV or BKV, none of the samples were found by a dot blot immunoassay to have antibodies which cross-reacted with simian virus 40. The results from this study, in agreement with those of others, suggest that humans infected by JCV or BKV produce antibodies to species-specific epitopes on their VP1 capsid protein, which is associated with hemagglutination and cellular binding.
Modelling the inbound tourism demand in Sri Lanka

Sri Lanka is one of the most popular tropical tourism destinations, due to its’ abundance of natural and cultural tourist attractions. During the 30-year civil war between the Liberation Tigers of Tamil Eelam (LTTE) and the Sri Lankan armed forces in Northern and Eastern Sri Lanka however, tourism demand declined, but since the end of war in 2009 it has steadily increased. To take advantage of this renewed interest in Sri Lanka as a preferred destination, it is necessary to identify the characteristics of the tourists from countries different to Sri Lanka and the determinants of tourism demand as a preferred destination. In this study, we identify seven major countries from where most of the tourists come to Sri Lanka and model the determinants of tourist numbers from these countries using annual data for the period 1994-2015.
Instructional Coaching Implementation: Considerations for K-12 Administrators

The No Child Left Behind (NCLB) Act of 2001 entrusted states to ensure that professional development for all teachers was “high quality;” however, it did not define “high quality” or explain how it was to be measured. While the law emphasized that activities were not to be isolated workshops or short-term conferences, there was little evidence that these recommendations were followed. With the passing of the Every Student Succeeds Act (ESSA, 2015), NCLB’s replacement, there have been many changes, including the elimination of the “high quality” terminology. Professional development expectations have been updated to “ensure personalized, ongoing, jobembedded activities” that are “available to all staff (including paraprofessionals), a part of broader school improvement plans, collaborative and data-driven, developed with educator input, and regularly evaluated” (Civic Impulse, 2016, n.p.). Along with providing a more descriptive definition of professional development (now United States policy), ESSA also transformed the professional development language from scientifically-based to evidence-based (Civic Impulse, 2016). Evidence-based professional development practices will push for greater emphasis on increasing student outcomes through teacher quality. But regardless of the federal legislation, effective professional development is vital to school improvement when administered appropriately (Guskey, 2002). For school administrators to effectively implement and hire instructional coaches, they must first have a deep understanding of instructional coaching, their partnerAs school leaders, 21st century school administrators are in the spotlight for their role in promoting an environment of academic achievement. Along with organizing and planning for the fundamental workings of their staff, students, activities, and building, administrators are expected to encompass numerous roles. In fact, two primary, yet conflicting activities expected from school administrators are leading and managing (Hall & Simeral, 2008). At the intersection of these primary activities is the evaluation and development of teachers as a means to improve student learning. While the management of formal teacher evaluations and observations is important for ensuring teacher accountability and quality, administrators are also needed to use evaluation data along with student achievement data to improve teacher practice.
Monetary Policy Shock and Financial Market Responses: An Empirical Study of Exchange Rate, Gold and International Equity Market

The asset pricing behavior around Rate Decision of The Central Bank is both an important and interesting Economic phenomenon. Predicting the direction and level of asset prices are important activities in the real world practice for investors. In this paper, I applied the Linear, Non-linear and Time Series methods to estimate the short term price change of several financial markets after the rate decision of FOMC in U.S. Fed by examine the data from 1990 to 2013. Our finding is that part of the asset pricing behavior is predictable conditional on the information set of rate decision. The unexpected part of hiking and cutting of benchmark overnight interest rate have significant influence on some asset classes. In the linear estimation parts, I found that the 1 basis point unexpected cut of the Fed Fund rate by the Fed Reserve in U.S. will drive 11 ticks rise of gold prices with significant level of 0.01. In the non-linear estimation parts, if the Fed Reserve cut its interest rate unexpectedly by 125 basis points, the probability that the Japanese Yen rises will be about 0.91, gold price rises will be about 0.80, the HangSeng Index rises will be 1.00, and the TSE rises will be about 0.98. My results are consistent with the hypothesis of rational behavior of economic agents in financial market and the related theory such as UIP(Uncovered Interest Rate Parity), Gold price as a prediction of inflation and international transmission of monetary policy through equity market.