Miracle-dz/UniFAR-FTUs huggingface dataset:
Epilepsy Surgery in the First 3 Years of Life: Predictors of Seizure Freedom and Cognitive Development.

BACKGROUND Although the majority of children undergoing epilepsy surgery are younger than 3 yr at epilepsy manifestation, only few actually receive surgical treatment in early childhood. Past studies have, however, suggested that earlier intervention may correlate with superior developmental outcomes. OBJECTIVE To identify predictors for long-term seizure freedom and cognitive development following epilepsy surgery in the first 3 yr of life and determine the appropriate timing for surgical treatment in this age group. METHODS We retrospectively analyzed the data of 48 consecutive children aged 1.1 ± 0.7 yr at surgery. RESULTS Final surgeries comprised 52% hemispherotomies, 13% multilobar, and 35% intralobar resections. Etiology included cortical malformations in 71%, peri- or postnatal ischemic lesions in 13%, and benign tumor or tuberous sclerosis in 8% each. At last follow-up (median 4.3, range 1-14.3 yr), 60% of children remained seizure-free: 38% had discontinued antiepileptic drugs. Intralobar lesionectomy resulted more often in seizure control than multilobar or hemispheric surgery. Postsurgical seizure freedom was determined by the completeness of resection. Early postsurgical seizures were key markers of seizure recurrence. Presurgical adaptive and cognitive developmental status was impaired in 89% children. Longer epilepsy duration and larger lesion extent were detrimental to presurgical development, which, in turn, determined the postsurgical developmental outcome. CONCLUSION Our study demonstrates that epilepsy surgery in very young children is safe as well as efficient regarding long-term seizure freedom and antiepileptic drug cessation in selected candidates. Longer epilepsy duration is the only modifiable predictor of impaired adaptive and cognitive development, thus supporting early surgical intervention.
An Augmented Perceptual-Cognitive Intervention Using a Pattern Recall Paradigm With Junior Soccer Players

In sport, perceptual skill training software is intended to assist tactical training in the field. The aim of this field study was to test whether “laboratory-based” pattern recall training would augment tactical skill training performed on the field. Twenty-six soccer players between 14 and 16 years of age from a single team participated in this study and were divided into three groups. The first received field training on a specific tactical skill plus cognitive training sessions on the pattern recall task. The second performed only the field training while the third group served as a control group and had field training on other topics. The task on the pre-, post-, and retention-tests was to recall specific soccer patterns displayed on a computer screen. Results showed significant changes between pre- and post-test performance. There was no significant interaction between groups and tests but the effect size was large. From pre- to retention-test, there was a significant difference between tests and an interaction between groups and tests, but no main effect difference between groups. On the basis of significance testing only retention was affected by the additional training, however, descriptive results and effect sizes from pre- to post-test were as expected and suggested there were learning benefits. Together these results indicate that augmented perceptual-cognitive training might be beneficial, but some limitations in our study design (e.g., missing field test, missing placebo group, etc.) need to be improved in future work.
Multiple Coordinated Views at Large Displays for Multiple Users: Empirical Findings on User Behavior, Movements, and Distances

Interactive wall-sized displays benefit data visualization. Due to their sheer display size, they make it possible to show large amounts of data in multiple coordinated views (MCV) and facilitate collaborative data analysis. In this work, we propose a set of important design considerations and contribute a fundamental input vocabulary and interaction mapping for MCV functionality. We also developed a fully functional application with more than 45 coordinated views visualizing a real-world, multivariate data set of crime activities, which we used in a comprehensive qualitative user study investigating how pairs of users behave. Most importantly, we found that flexible movement is essential and—depending on user goals—is connected to collaboration, perception, and interaction. Therefore, we argue that for future systems interaction from the distance is required and needs good support. We show that our consistent design for both direct touch at the large display and distant interaction using mobile phones enables the seamless exploration of large-scale MCV at wall-sized displays. Our MCV application builds on design aspects such as simplicity, flexibility, and visual consistency and, therefore, supports realistic workflows. We believe that in the future, many visual data analysis scenarios will benefit from wall-sized displays presenting numerous coordinated visualizations, for which our findings provide a valuable foundation.
Dwarf mistletoe infection in jack pine alters growth–defense relationships

Trees utilize a combination of chemical and anatomical defenses against a myriad of attacking organisms. However, persistent pathogen infection that alters resource acquisition may impact growth and defense relationships, which could have consequences for tree resistance. We characterized systemic chemical and anatomical changes in jack pine (Pinus banksiana) in response to infection by the parasitic plant dwarf mistletoe (Arceuthobium americanum) and identified how the growth-defense relationship is altered due to infection severity. Our study found that the growth and defense relationship in jack pine was altered due to infection and that chemical defenses in the phloem received a relatively higher priority than radial growth and anatomical defenses. Chemical defenses in the phloem had a non-linear relationship with infection severity with increasing concentrations of monoterpenes in trees with moderate infection and decreasing concentrations at high infection. In contrast, both radial growth and vertical resin duct production decreased with increasing infection severity. While constitutive resin duct counts and many monoterpene compound concentrations were positively correlated, this relationship was not maintained in infected trees. Furthermore, radial growth and basal area increment was positively correlated with resin duct production and monoterpene concentration in non-infected trees but had fewer relationships in severely infected trees. We conclude that while both chemical and anatomical defenses may be used as indicators for potential resistance to biotic stress in pines, changes in resource allocation patterns between these defenses after infection will likely have consequences on tree resistance to subsequent biotic attacks.
A metamodel for the specification and verification of model refactoring actions

Refactoring has become a valuable activity during the software development lifecycle, because it can be induced by different causes, like new requirements or quality improvement. In code-based development contexts this activity has been widely studied, whereas in model-driven ones, where models are first-class development entities, there are many issues yet to be tackled. In this paper we present a metamodel that supports the specification of pre- and post- conditions of model refactoring actions, and the automated derivation and verification of such conditions in specific modeling languages. Our work is aimed at helping users to implement refactoring actions in the adopted modelling language by providing an environment for guaranteeing the feasibility of refactoring actions. Our primary focus is on the definition of applicable sequences of refactoring actions, rather than on the user-driven step-by-step application of refactoring actions. As an example, we illustrate the applicability of our metamodel for UML models refactoring.
MCO: towards an ontology and unified vocabulary for a framework‐based annotation of microbial growth conditions

Motivation: A major component in increasing our understanding of the biology of an organism is the mapping of its genotypic potential into its phenotypic expression profiles. This mapping is executed by the machinery of gene regulation, which is essentially studied by changes in growth conditions. Although many efforts have been made to systematize the annotation of experimental conditions in microbiology, the available annotations are not based on a consistent and controlled vocabulary, making difficult the identification of biologically meaningful comparisons of knowledge derived from different experiments or laboratories. Results: We curated terms related to experimental conditions that affect gene expression in Escherichia coli K‐12. Since this is the best‐studied microorganism, the collected terms are the seed for the Microbial Conditions Ontology (MCO), a controlled and structured vocabulary that can be expanded to annotate microbial conditions in general. Moreover, we developed an annotation framework to describe experimental conditions, providing the foundation to identify regulatory networks that operate under particular conditions. Availability and implementation: As far as we know, MCO is the first ontology for growth conditions of any bacterial organism, and it is available at http://regulondb.ccg. unam.mx and https://github.com/microbial‐conditions‐ontology. Furthermore, we will disseminate MCO throughout the Open Biological and Biomedical Ontology (OBO) Foundry in order to set a standard for the annotation of gene expression data. This will enable comparison of data from diverse data sources. Supplementary information: Supplementary data are available at Bioinformatics online.
Lymph node ratio as a valuable prognostic factor for patients with colorectal liver-only metastasis undergoing curative resection

Background Recent studies have suggested that the lymph node ratio (LNR) is a prognostic indicator for various malignancies. However, LNR has not been evaluated in colorectal liver-only metastasis (CRLM). This study aimed to investigate the prognostic value of LNR in patients with CRLM after curative resection. Patients and methods We retrospectively investigated the clinicopathologic features of 154 CRLM patients who underwent curative resection between 2005 and 2015. We classified patients into low and high groups based on their LNR by using the X-tile software. Survival curves were plotted through Kaplan–Meier method and compared by log-rank test. Cox proportional hazards analysis was performed to identify the factors associated with recurrence-free survival (RFS) and overall survival (OS). Results The patients were divided into two groups in which 124 patients were identified as LNR ≤0.33 and 30 patients as LNR >0.33. Compared to low LNR, high LNR was significantly associated with poor 3-year RFS (47.2% vs 16.7%, P=0.001) and OS (72.8% vs 45.3%, P=0.003) rates. Multivariate analysis indicated that the LNR was an independent predictor for 3-year RFS (hazard ratio, 2.124; 95% CI, 1.339–3.368; P=0.001) and OS (HR, 2.287; 95% CI, 1.282–4.079; P=0.005). However, the node (N) stage and lymph node distribution were not significantly associated with the 3-year RFS (P=0.071, P=0.226) or OS (P=0.452, P=0.791) in patients with CRLM. Conclusion This study demonstrated that LNR was an independent predictor for 3-year RFS and OS in patients with CRLM who underwent curative resection and that its prognostic value was superior to that of N stage and lymph node distribution.
Investigando a Relação das Refatorações de Código com os Sentimentos de Mensagens de Commit

Este trabalho apresenta um estudo a partir da análise de sentimentos em mensagens expressas pelos desenvolvedores por meio de commits em repositórios de código aberto. Foram analisados seis projetos de código aberto em um total de 12.113 mensagens de commit. Para o estudo foram classificadas as mensagens dos commits em duas categorias: positivo ou negativo. Em seguida, e realizada uma investigação se os sentimentos estão relacionados às atividades de refatoração de código. Como resultados deste estudo, tem-se indícios que quando se trabalha com refatorações a tendência é a expressar menos sentimentos negativos.
Emotion Analysis of Reaction to Terrorism on Twitter

Terrorism events impact people in several manners. Reactions may include losing sense of safety and experiencing angry and fear, among others. The social media has become an important mean where people express themselves. We target Twitter to investigate the emotional reaction people have to terrorism events. For this purpose, we analyze emotions in tweets along with demographic data. Tracking emotional reaction can help in defining specific assistance programs. In our approach we collect a corpus of tweets related to two terrorism events, classify emotions, extract user location and estimate user age and gender with use of available tools. Results showed an emotion shift due to the events and a difference on the reaction from one event to another.
Influenza in New Zealand Before 1918: A Preliminary Report

In the present article, I aimed to test the hypothesis that possible fatal immunological reactions to the A/H1N1 virus of the 1918 "Spanish" influenza pandemic were the result of previous exposure to the A/H3N8 virus of the 1890-1892 "Russian" influenza pandemic. Using newspapers and official death records to reconstruct mortality peaks from influenza and excess pneumonia deaths in New Zealand before 1918 enabled comparisons with peaks of influenza mortality by age in 1918 from individual death records. For males, mortality peaks in the 1885, 1890-1892, 1894, and 1898 influenza outbreaks appeared to match those from the 1918 pandemic. For females, peaks of deaths in 1918 corresponded to those from the influenza outbreaks of 1887 and 1890-1892. The highest mortality rates for both sexes were among those 28-32 years of age. Although they lend strong support to the hypothesis of fatal immunological reactions derived from early exposure to a different influenza virus, the results from this study also raise more questions: Given that the A/H1N1 virus of 1918 was exceptionally virulent, why did so few children 5-15 years of age die from it? Influenza normally kills only the very young and the very old. In addition, why did twice as many European males as females die in the young-adult age groups, whereas Māori males and females died at almost identical rates?
Glioblastoma Treated With Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy: Safety, Efficacy, and Outcomes

Abstract BACKGROUND Despite the multitude of available treatments, glioblastoma (GBM) remains an aggressive and uniformly fatal tumor. Laser interstitial thermal therapy (LITT) is a novel, minimally invasive treatment that holds promise for treating patients with GBM who are not candidates for traditional open craniotomy. However, due to the recent introduction of LITT into clinical practice, large series that evaluate safety and long-term outcomes after LITT are lacking. OBJECTIVE To present our institution's series of over 50 GBM patients treated with LITT, with regard to safety, efficacy, and outcomes. METHODS We performed a retrospective descriptive study of patients with histologically proven GBM who underwent LITT. Data collected included demographics, tumor location and volume, tumor genetic markers, treatment volume, perioperative complications, and long-term follow-up data. RESULTS We performed 58 LITT treatments for GBM in 54 patients over 5.5 yr. Forty-one were recurrent tumors while 17 were frontline treatments. Forty GBMs were lobar in location, while 18 were in deep structures (thalamus, insula, corpus callosum). Average tumor volume was 12.5 ± 13.4 cm3. Average percentage of tumor treated with the yellow thermal damage threshold (TDT) line (dose equivalent of 43°C for 2 min) was 93.3% ± 10.6%, and with the blue TDT line (dose equivalent of 43°C for 10 min) was 88.0% ± 14.2%. There were 7 perioperative complications (12%) and 2 mortalities (3.4%). Median overall survival after LITT for the total cohort was 11.5 mo, and median progression-free survival 6.6 mo. CONCLUSION LITT appears to be a safe and effective treatment for GBM in properly selected patients.
Cost analysis for different sequential treatment regimens for metastatic renal cell carcinoma in China

Abstract Purpose: Targeted therapies, including sunitinib, sorafenib, axitinib, and everolimus, have recently become the mainstay for the treatment of metastatic renal cell carcinoma (mRCC). The objective of this study was to estimate the costs of sequential treatment regimens for mRCC and associated adverse events (AEs) from the Chinese payers’ perspective. Methods: Key inputs included in the calculation were patient population, dosing information, incidence rates and associated costs of Grade 3/4 AEs, treatment costs (including drug discount programs), and patients’ progression-free survival (PFS) as a proxy for length of treatment. To calculate PFS, this study identified pivotal clinical trials and generated a reconstructed individual patient data set from the published Kaplan-Meier survival curves. The median PFS from the pooled estimates were used in the calculation. In the base-case scenario, sunitinib was used as first line and the other three therapies were used as second line. Sensitivity analyses were conducted where (1) sorafenib was used as first line, or (2) a third-line therapy was added to the base-case scenario. Results: In the base case, the cost per patient per treatment month (PPPM) cost was the lowest for sunitinib + axitinib among all sequential regimens (¥14,898) and was the highest for sunitinib + sorafenib (¥20,103). If sorafenib is used as first line, everolimus had lower per patient per months (PPPM) cost than axitinib (¥17,046 vs ¥23,337), but also had shorter PFS (13.5 months vs 15 months). Second sensitivity analysis with an additional third-line therapy showed consistent results with the base-case scenario; axitinib as second line was the least costly. Conclusions: This study demonstrates that, for mRCC sequential treatment, sunitinib followed by axitinib generates the highest cost savings from the Chinese payers’ perspective. Future studies are warranted to examine the cost-effectiveness of various mRCC treatment regimens in Chinese populations.
Global Effects of Focal Brain Tumors on Functional Complexity and Network Robustness: A Prospective Cohort Study

Abstract BACKGROUND Neurosurgical management of brain tumors has entered a paradigm of supramarginal resections that demands thorough understanding of peritumoral functional effects. Historically, the effects of tumors have been believed to be local, and long-range effects have not been considered. OBJECTIVE To test the hypothesis that tumors affect the brain globally, producing long-range gradients in cortical function. METHODS Resting-state functional magnetic resonance imaging (fMRI) data were acquired from 11 participants with glioblastoma and split into discovery and validation datasets in a single-center prospective cohort study. Fractal complexity was computed with a wavelet-based estimator of the Hurst exponent. Distance-related effects of the tumors were tested with a tumor mask-dilation technique and parcellation of the underlying Hurst maps. RESULTS Fractal complexity demonstrates a penumbra of suppression in the peritumoral region. At a global level, as distance from the tumor increases, this initial suppression is balanced by a subsequent overactivity before finally normalizing. These effects were best fit by a quadratic model and were consistent across different network construction pipelines. The Hurst exponent was correlated with graph theory measures of centrality including network robustness, but graph theory measures did not demonstrate distance-dependent effects. CONCLUSION This work provides evidence supporting the theory that focal brain tumors produce long-range gradients in function. Consequently, the effects of focal lesions need to be interpreted in terms of the global changes on functional complexity and network architecture rather than purely in terms of functional localization. Determining whether peritumoral changes represent potential plasticity may facilitate extended resection of tumors without functional cost.
Functional analysis of UGT201D3 associated with abamectin resistance in Tetranychus cinnabarinus (Boisduval)

Uridine diphosphate (UDP)‐glycosyltransferases (UGTs) are widely distributed within living organisms and share roles in biotransformation of various lipophilic endo‐ and xenobiotics with activated UDP sugars. In this study, it was found that the activity of UGTs in abamectin‐resistant (AbR) strain was significantly higher (2.35‐fold) than that in susceptible strain (SS) of Tetranychus cinnabarinus. Further analysis showed that 5‐nitrouracil, the inhibitor of UGTs, could enhance the lethal effect of abamectin on mites. From the previous microarray results, we found an UGT gene (UGT201D3) overexpressed in AbR strain. Quantitative PCR analysis showed that UGT201D3 was highly expressed and more inducible with abamectin exposure in the AbR strain. After silencing the transcription of UGT201D3, the activity of UGTs was decreased and the susceptibility to abamectin was increased in AbR strain whereas it was not in SS. Furthermore, UGT201D3 gene was then successfully expressed in Escherichia coli. The recombinant UGT201D3 exhibited α‐naphthol activity (2.81 ± 0.43 nmol/mg protein/min), and the enzyme activity could be inhibited by abamectin (inhibitory concentration at 50%: 57.50 ± 3.54 μmol/L). High‐performance liquid chromatography analysis demonstrated that the recombinant UGT201D3 could effectively deplete abamectin (15.77% ± 3.72%) incubating with 150 μg protein for 6 h. These results provided direct evidence that UGT201D3 was involved in abamectin resistance in T. cinnabarinus.
Measurement and Application of Hyperspectral Characteristics of Boiled Egg Yolk

The establishment of egg quality traceability system is a reliable system for the identification and supervision of egg quality. In order to provide a reliable data source for the traceability of eggs, this paper proposes a detection method to identify egg quality by using the hyperspectral characteristics of boiled egg yolk. The proposed new method uses the ground spectrometer to obtain high resolution spectral data of boiled egg yolk. Then these data perform the pretreated and compared operations, and can identify the egg freshness and egg yolk composition. They do not require egg quality parameters as a reference. The experimental results show that this method is effective, and this proposes a new idea for egg quality detection.