Miracle-dz/UniFAR-FTUs huggingface dataset:
Supply Chain Partner Communication in a Managed Programme in the UK Water Industry: A Case Study with Social Network Analysis

The water industry in every country aims to effectively and efficiently provide water with satisfactory quality in a sustainable and environmentally friendly manner. To this end, it is critical to achieve effective communication among the partners in water supply chain networks. In this paper, we focus on one of the UK’s largest water utility companies and its eight main contractors and analyze the factors influencing partner and network communication in a managed programme of their asset supply chain. We employ social network analysis to conduct the cross-sectional and longitudinal analysis of partner communication. Factors found to influence the communication network are grouping of projects within the programme, individual’s organisational affiliation, status, tenure, elapsed time through the programme lifecycle, and co-location. Our contributions to practice include demonstrating water programme management factors that influence communication and trust and how social network analysis can better inform them about intra- and interorganisational relationships. Moreover, the methodology introduced in this study may be applied to water management in other parts of the world.
Multidimensional Analysis of Plates with Irregularities Using Higher-Order Finite Elements Based on Lobatto Shape Functions

Direct modeling and simulation of engineering problems with various irregularities are computationally very inefficient and in some cases impossible, even in these days of massively parallel computational systems. As a result, in recent times, a number of schemes have been put forward to tract such problems in a computationally efficient manner. Needless to say, such schemes are still going through evolutionary stages. This paper addresses direct solution based on the selective use of different dimensional models at different regions of the problem domain. For the multidimensional approach, a higher-order transition element is developed to connect the different element types where two- and three-dimensional laminated elements based on higher-order subparametric concept are considered. Modeling simplicity and calculation efficiency of the multidimensional approach are shown for the analysis of cantilever plates with stepped section and patch-repaired plates.
EVALUATION OF RESEARCH-DEVELOPMENT-INNOVATION IN THE CONTEXT OF STRATEGIC MANAGEMENT

The more and more accelerated scientific and technological progress in advanced economies and the increase in complexity of the uncertainty and non-repetitiveness characteristics of the RDI activities call more and more for the diversification, perfection and refinement of the evaluation methods for the efficiency and effectiveness of the RDI activity, in the short, medium and long run, under the new conditions of globalization and assertion of knowledge-based society. The notion of “research evaluation” is approached in the broader context of strategic management, where the process of financing and evaluating costs and RDI results are primary elements. The strategic dimension of research management consists in a series of priorities within various time horizons. Strategic research management interferes with the other components of the national economic and social development programs, with the opportunities offered by the European Research Area and other bilateral and multilateral forms of collaboration with other non-member countries.
Diet digestibility and performance of dairy cows supplemented with live yeast

A suplementacao com levedura pode melhorar a eficiencia digestiva de ruminantes. Entretanto, a resposta depende da cepa de levedura e da composicao da dieta. Silagem de milho e polpa citrica sao fontes frequentes de carboidratos para vacas leiteiras no Sudeste do Brasil. Avaliou-se a suplementacao de vacas leiteiras alimentadas com dieta baseada em silagem de milho e polpa citrica com Saccharomyces cerevisiae cepa CNCM I1077 (Lallemand SAS, Toulouse, Franca). Vinte vacas Holandesas multiparas em meio de lactacao foram alocadas a uma sequencia de dois tratamentos em delineamento de reversao simples. Os tratamentos foram: 10 g de levedura viva em farinha de ostra para fornecer um minimo diario de 1 × 1010 ufc por vaca ou farinha de ostra fornecidos sobre a refeicao matinal. A dieta continha (% da materia seca): 16,8% de proteina bruta, 30,9% de fibra em detergente neutro, 43,9% de silagem de milho, 2% de feno de tifton, 14,4% de milho floculado, 16,9% de polpa citrica e 21,7% de farelo de soja. A suplementacao com levedura aumentou as producoes diarias de leite (29,4 vs. 28,5 kg, p = 0,11), proteina (0,939 vs. 0,908 kg, p = 0,05) e lactose (1,264 vs. 1,241 kg, p = 0,06), e nao teve efeito sobre a gordura do leite (p = 0,53). O consumo diario de materia seca foi 21,4 kg com levedura e 20,7 no controle (p = 0,11). A digestibilidade aparente da fibra em detergente neutro no trato digestivo total foi 48,1% com levedura e 43,2% para o controle (p = 0,08). Houve tendencia de aumento no consumo de materia orgânica digestivel com a suplementacao de levedura (p = 0,07). A resposta positiva em secrecao de proteina do leite a suplementacao com levedura parece ter sido resultado do aumento na digestibilidade da fibra, mas o mecanismo para a resposta nao pode ser elucidado.
Combating Antimicrobial Resistance in Singapore: A Qualitative Study Exploring the Policy Context, Challenges, Facilitators, and Proposed Strategies

Antimicrobial resistance (AMR) is a global public health threat that warrants urgent attention. However, the multifaceted nature of AMR often complicates the development and implementation of comprehensive policies. In this study, we describe the policy context and explore experts’ perspectives on the challenges, facilitators, and strategies for combating AMR in Singapore. We conducted semi-structured interviews with 21 participants. Interviews were transcribed verbatim and were analyzed thematically, adopting an interpretative approach. Participants reported that the Ministry of Health (MOH) has effectively funded AMR control programs and research in all public hospitals. In addition, a preexisting One Health platform, among MOH, Agri-Food & Veterinary Authority (restructured to form the Singapore Food Agency and the Animal & Veterinary Service under NParks in April 2019), National Environment Agency, and Singapore’s National Water Agency, was perceived to have facilitated the coordination and formulation of Singapore’s AMR strategies. Nonetheless, participants highlighted that the success of AMR strategies is compounded by various challenges such as surveillance in private clinics, resource constraints at community-level health facilities, sub-optimal public awareness, patchy regulation on antimicrobial use in animals, and environmental contamination. This study shows that the process of planning and executing AMR policies is complicated even in a well-resourced country such as Singapore. It has also highlighted the increasing need to address the social, political, cultural, and behavioral aspects influencing AMR. Ultimately, it will be difficult to design policy interventions that cater for the needs of individuals, families, and the community, unless we understand how all these aspects interact and shape the AMR response.
Analisis Tema Skripsi Mahasiswa Menggunakan Document Clustering Dengan Algoritma LINGO

In information technology field, there were many topics that could be selected as a theme of thesis. Unfortunately, it was often for student to take same topics as the previous generation student’s. Having a similar theme, it caused similar thesis titles. This made the research among college students could not develop quickly. Supposedly, the theme that has often been selected by students should be replaced with new themes deal with new trend. This study aimed to analyze thesis themes frequently used by student. Thesis theme could be analyzed from the title and abstract. Because the data used in this study is textual data, then analyzing were performed on text mining methods, the document clustering, using a clustering algorithm LINGO. Document clustering was applied using software Carrot2 Workbench. The results of this study were clusters consisting of the input documents. Each group has a label. The label reflects member similarity in a group. From this cluster label could be analyzed the thesis theme.
Nursing Students’ Knowledge and Awareness of Antibiotic Use, Resistance and Stewardship: A Descriptive Cross-Sectional Study

Antibiotic resistance is an emerging worldwide concern with serious repercussions in terms of morbi-mortality. Bearing in mind that the inadequate use of antibiotics, by healthcare staff as well as by the general population, is one of its main causes, a multidisciplinary approach is required to try to combat it. The aim of the present study was to determine nursing students’ knowledge and awareness of antibiotic use, resistance and stewardship. A cross-sectional design was used. A total of 578 nursing students from the University of Santiago de Compostela (Spain), ≥18 years old of both sexes were invited to complete the Spanish version of the questionnaire “Knowledge and awareness of the use, resistance and administration of antibiotics” between February and April 2019. Students had a low level of knowledge about antibiotics, 4.1 (CI95% = 3.4–4.8), especially in relation to antibiotic resistance. As the students were aware of this deficiency, the majority affirmed (>90%) that the current curriculum of nursing degree should have more training on antibiotics and infection control. Nursing staff play an important role in the rational use of antibiotics and as teachers of patients, so their training could be key in fighting antibiotic resistance.
Immunotherapies and Future Combination Strategies for Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage and has a dismal prognosis. Nearly 10 years after the approval of cetuximab, anti-PD1/PD-L1 checkpoint inhibitors are the first drugs that have shown any survival benefit for the treatment on platinum-refractory recurrent/metastatic (R/M) HNSCC. Furthermore, checkpoint inhibitors are better tolerated than chemotherapy. The state of the art in the treatment of R/M HNSCC is changing, thanks to improved results for checkpoint inhibitors. Results for these treatments are also awaited in curative settings and for locally advanced HNSCC. Unfortunately, the response rate of immunotherapy is low. Therefore, the identification of predictive biomarkers of response and resistance to anti-PD1/PD-L1 is a key point for better selecting patients that would benefit the most from immunotherapy. Furthermore, the combination of checkpoint inhibitors with various agents is being currently evaluated to improve the response rate, prolong response duration, and even increase the chances for a cure. In this review, we summarize the most important results regarding immune targeting agents for HNSCC, predictive biomarkers for resistance to immune therapies, and future perspectives.
The cost-effectiveness of metformin in pre-diabetics: a systematic literature review of health economic evaluations

ABSTRACT Objectives: Our aim was to systematically identify and appraise cost-effectiveness studies of metformin in prediabetic subjects. Methods: A systematic literature review was conducted and reported according to standard guidlines. The search was conducted in PubMed, Embase, International Society for Pharmacoeconomics and Outcomes Research (ISPOR) presentation database and the Cost-Effectiveness Analysis (CEA) and Center for Reviews and Dissemination (CRD) registries. All cost-effectiveness studies assessing metformin in prediabetic patients were included. Results: Twenty-three reports were included. Metformin and intensive lifestyle changes (ILC) interventions were always cost-effective compared to placebo. ILC was cost-effective and sometimes dominant compared to metformin. Metformin was cost-saving compared to ILC in the short and medium-term. Although, in the long term, metformin was more expensive than ILC in terms of direct medical costs, when indirect non-medical costs are included, metformin less expensive than ILC. One study reported that for patients with Body Mass Index (BMI) higher than 30 kg/m2, metformin is a cost-effective strategy compared to placebo and ILC. However, this finding was not confirmed by other retrieved studies. Conclusion: ILC is cost-effective compared to metformin and, both of them are cost-effective compared to placebo. Metformin may be cost-saving in the short- to medium-term and possibly in the long-term.
University of Southern Denmark The effect of 8 weeks of treatment with transcranial pulsed electromagnetic fields on hand tremor and inter-hand coherence in persons with Parkinson's disease Malling,

Background: Parkinson’s disease (PD) tremor comprises asymmetric rest and postural tremor with unilateral onset. Tremor intensity can be amplified by stress and reduced by attention, and the medical treatment is complex. Mirror movements and unintentional synchronization of bimanual movements, possibly caused by insufficient inhibition of inter-hemispheric crosstalk, have been reported in PD, indicating a lag of lateralization. Potential neuroprotective effects of pulsed electromagnetic fields (PEMF) have been reported in-vitro and in rodents, as have influences of PEMF on human tremor. The aim was to investigate the effect of 8 weeks daily transcranial PEMF treatment (T-PEMF) of persons with PD on rest and postural hand tremor characteristics and on inter-hand coherence. Methods: Hand accelerations of 50 PD participants with unior bilateral tremor participating in a clinical trial were analysed. A rest and postural tremor task performed during serial subtraction was assessed before and after 8 weeks of T-PEMF (30 min/day, 50 Hz, ±50 V, 3 ms squared pulses) or placebo treatment (sham stimulation 30 min/day). Forty matched healthy persons (no treatment) were included as reference. Intensity and inter-hand coherence related measures were extracted. Results: The T-PEMF treatment decreased the inter-hand coherence in the PD group with unilateral postural tremor. The PD group with unilateral postural tremor was less clinically affected by the disease than the PD group with bilateral postural tremor. However, no differences between T-PEMF and placebo treatment on either intensity related or coherence related measures were found when all persons with PD were included in the analyses. The peak power decreased and the tremor intensity tended to decrease in both treatment groups. (Continued on next page) * Correspondence: amalling@health.sdu. dk; asmalling@hotmail.com ˆDeceased Department of Neurology, Odense University Hospital, University of Southern Denmark, Odense, Denmark Department of Clinical Research, University of Southern Denmark, Odense, Denmark Full list of author information is available at the end of the article © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Malling et al. Journal of NeuroEngineering and Rehabilitation (2019) 16:19 https://doi.org/10.1186/s12984-019-0491-2
Humerus osteology, myology, and finite element structure analysis of Cheloniidae

Adaptation of osteology and myology lead to the formation of hydrofoil foreflippers in Cheloniidae (all recent sea turtles except Dermochelys coriacea) which are used mainly for underwater flight. Recent research shows the biomechanical advantages of a complex system of agonistic and antagonistic tension chords that reduce bending stress in bones. Finite element structure analysis (FESA) of a cheloniid humerus is used to provide a better understanding of morphology and microanatomy and to link these with the main flipper function, underwater flight. Dissection of a Caretta caretta gave insights into lines of action, that is, the course that a muscle takes between its origin and insertion, of foreflipper musculature. Lines of action were determined by spanning physical threads on a skeleton of Chelonia mydas. The right humerus of this skeleton was micro‐CT scanned. Based on the scans, a finite element (FE) model was built and muscle force vectors were entered. Muscle forces were iteratively approximated until a uniform compressive stress distribution was attained. Two load cases, downstroke and upstroke, were computed. We found that muscle wrappings (m. coracobrachialis magnus and brevis, several extensors, humeral head of m. triceps) are crucial in addition to axial loading to obtain homogenous compressive loading in all bone cross‐sections. Detailed knowledge on muscle disposition leads to compressive stress distribution in the FE model which corresponds with the bone microstructure. The FE analysis of the cheloniid humerus shows that bone may be loaded mainly by compression if the bending moments are minimized.
New York State Emergency Preparedness and Response to Influenza Pandemics 1918–2018

Emergency health preparedness and response efforts are a necessity in order to safeguard the public against major events, such as influenza pandemics. Since posting warnings of the epidemic influenza in 1918, to the mass media communications available a century later, state, national and global public health agencies have developed sophisticated networks, tools, detection methods, and preparedness plans. These progressive measures guide health departments and clinical providers, track patient specimens and test reports, monitor the spread of disease, and evaluate the most threatening influenza strains by means of risk assessment, to be able to respond readily to a pandemic. Surge drills and staff training were key aspects for New York State preparedness and response to the 2009 influenza pandemic, and the re-evaluation of preparedness plans is recommended to ensure readiness to address the emergence and spread of a future novel virulent influenza strain.
The Potential of Non-Mega Sporting Events for the Promotion of Physical Activity Among Inactive Supporters at the Poznan Half Marathon: A Case Study

The impact of sports events on the promotion of physical activity, healthy lifestyles and sports participation is debatable, and most of the literature is on mega-events. This begs the question if more evidence of this type of impact can be found for non-mega events. Research on sports legacy often refers to the tangible effects such as infrastructure that is left after the competition. However, the construction of new facilities does not automatically result in attracting participants. Despite the high expectations of events organizers in terms of their impacts on pro-health behavior of people, few studies provide empirical evidence that events encourage sport fans to become more physically active. The aim of this research was to examine whether a mass run promotes physical activity among spectators, and whether a mass run influences the willingness of spectators to start in half marathon in the future. A written paper–pencil survey was collected from 510 spectators during the 6th Poznan Half Marathon. The results show that observing a mass run event has a positive impact on the willingness to engage in regular physical activity as well as the willingness to take part in this type of sport in the future. Our work provides knowledge about the level of effectiveness in promoting active lifestyles among supporters depending on age, sex and place of residents. This work focuses on mass runs, which have been under-researched when it comes to impact on sport participation.
Resistance to β-Lactam Antibiotics in Bacteroides Spp.

Summary Bacteroides spp. , particularly B. fragilis, are well-recognised bacterial pathogens. Production of the typical β-lactamases of Bacteroides restricts the therapeutic use of β-lactam agents mainly to the β-lactamase inhibitor combinations and carbapenems. These compounds have the advantage of broad-spectrum activity and the ability to combat polymicrobial infections. Resistance of Bacteroides spp. to β-lactam antibiotics appears to be increasing, largely because of an overall increase in β-lactamase activity. There has been a rise in the prevalence of isolates showing high-level production of typical Bacteroides β-lactamases and an increase in reports other potent β-lactamase types. In the case of B. fragilis, metallo-enzymes are a particular threat to current therapeutic practice, as they are not inhibited by common β-lactamase inhibitors and are able to hydrolyse carbapenems. The presence of permeability barriers may confer low-level β-lactam resistance and supplement the effect of β-lactamase activity. There are also sporadic reports of loss of β-lactam activity because of reduced affinity of the penicillin-binding proteins.
Organic Farming and Good Agriculture Practices (Global GAP) to Achieve Food Safety for Crops: As a Review

Organic farming refers to agricultural production systems used to produce food and fiber. Organic farming management relies on developing biological diversity in the field to disrupt habitat for pest organisms, and the purposeful maintenance and replenishment of soil fertility. Organic farmers are not allowed to use synthetic pesticides or fertilizers. All kinds of agricultural products are produced organically, including produce vegetable crops, grains, meat, dairy, eggs, flowers, and processed food products. Some of the essential characteristics of organic systems include: design and implementation of an "organic system plan" that describes the practices used in producing crops and livestock products; a detailed recordkeeping system that tracks all products from the field to point of sale; and maintenance of buffer zones to prevent inadvertent contamination by synthetic farm chemicals from adjacent conventional fields. The concept of Good Agricultural Practices (GAP) has evolved in recent years in the context of a rapidly changing and globalizing food economy and as a result of the concerns and commitments of a wide range of stakeholders regarding food production and security, food safety and quality, and the environmental sustainability of agriculture. These stakeholders represent actors from the supply dimension (farmers, farmers’ organizations, workers), the demand dimension (retailers, processors and consumers) and those institutions and services (education, research, extension, input supply) that support and connect demand and supply and who seek to meet specific objectives of food security, food quality, production efficiency, livelihoods and environmental conservation in both the medium and long term.