Miracle-dz/UniFAR-FTUs huggingface dataset:
Rates of symptom reporting following traumatic brain injury

Abstract This study examines rates of reporting of new or worse post-traumatic symptoms for patients with a broad range of injury severity at 1 month and 1 year after traumatic brain injury (TBI), as compared with those whose injury spared the head, and assesses variables related to symptom reporting at 1 year post-injury. Seven hundred thirty two TBI subjects and 120 general trauma comparison (TC) subjects provided new or worse symptom information at 1 month and/or 1 year post-injury. Symptom reporting at 1 year post-injury was compared in subgroups based on basic demographics, preexisting conditions, and severity of brain injury. The TBI group reported significantly more symptoms at 1 month and 1 year after injury than TCs (each p < .001). Although symptom endorsement declined from 1 month to 1 year, 53% of people with TBI and 24% of TC continued to report 3 or more symptoms at 1 year post-injury. Symptom reporting in the TBI group was significantly related to age, gender, preinjury alcohol abuse, pre-injury psychiatric history, and severity of TBI. Symptom reporting is common following a traumatic injury and continues to be experienced by a substantial number of TBI subjects of all severity levels at 1 year post-injury. (JINS, 2010, 16, 401–411.)
Relationship between dietary phytoestrogens and development of urinary incontinence in midlife women

ObjectiveBecause exogenous estrogen treatment has been associated with a higher risk of urinary incontinence, our objective was to evaluate the longitudinal relationships of dietary phytoestrogen intakes (isoflavones, coumestans, and lignans) and the development of incontinence in midlife women transitioning through menopause. MethodsThe Study of Women’s Health Across the Nation (SWAN) Phytoestrogen Study was developed within SWAN, a community-based, multisite, multiracial/ethnic, prospective cohort study. SWAN interviewers administered a food consumption assessment at baseline and on follow-up visits 5 and 9. The SWAN Phytoestrogen Study created a phytonutrient database that allowed estimation of the usual daily intakes of four isoflavones, four lignans, and coumestrol. On an annual self-administered questionnaire, participants reported on the frequency and type of incontinence. We used discrete proportional hazards models to evaluate whether the estimated daily intake of each phytoestrogen class on the visit previous to the first report of incontinence was associated with the development of monthly or more incontinence versus remaining continent. ResultsWe found no association or patterns of association between developing any, stress, or urge incontinence and the reported daily dietary intake of isoflavones, coumestrol, and lignans on the visit previous to the onset of incontinence. ConclusionsThe results of this longitudinal study provide important information to better understand estrogenlike substances in the continence mechanism of midlife women. Our study shows that neither high nor low dietary intakes of isoflavones, coumestrol, and lignans prevent stress or urge incontinence. Future studies should evaluate whether serum levels of phytoestrogens or their metabolites impact incontinence symptoms.
Distribution of persistent, lipid-soluble chemicals in breast and abdominal adipose tissues: lessons learned from a breast cancer study.

OBJECTIVES We sought to determine differences between concentrations of persistent, lipid-soluble chemical contaminants in breast and abdominal adipose tissues and to explore whether concentrations measured in one tissue could predict concentrations in the other tissue. METHODS We analyzed surgical specimens and measured concentrations of prevalent dioxins, furans, polychlorinated biphenyls, organochlorine pesticides, and brominated diphenyl ethers to determine their partitioning between breast and abdominal adipose tissues of 21 women. The women constituted a subgroup, undergoing mastectomies with simultaneous breast reconstruction, of a case-control study evaluating links between breast cancer and body burdens of organohalogen contaminants. RESULTS For every contaminant, differences between concentrations in breast and abdominal adipose tissues did not exceed the analytical error. Results indicated that, with some notable exceptions, measurements in breast and abdominal adipose tissues were correlated and that concentrations of target chemicals in one tissue could be derived from measurements in the other tissue. CONCLUSIONS This information will allow comparison of results from body burden studies that used different tissues. It may also facilitate future breast cancer studies by allowing selection of controls among patients undergoing surgical procedures other than breast surgery, minimizing concerns about overmatching. We also observed large differences in the lipid content of surgical specimens. These differences underscore the need for lipid adjustment of concentrations to avoid misclassification.
Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

Several lines of evidence suggest that the presence of the wild‐type tumor suppressor gene p53 in human cancers correlates well with successful anti‐cancer therapy. Restoration of wild‐type p53 function to cancer cells that have lost it might therefore improve treatment outcomes. Using a systematic yeast genetic approach, we selected second‐site suppressor mutations that can overcome the deleterious effects of common p53 cancer mutations in human cells. We identified several suppressor mutations for the V143A, G245S and R249S cancer mutations. The beneficial effects of these suppressor mutations were demonstrated using mammalian reporter gene and apoptosis assays. Further experiments showed that these suppressor mutations could override additional p53 cancer mutations. The mechanisms of such suppressor mutations can be elucidated by structural studies, ultimately leading to a framework for the discovery of small molecules able to stabilize p53 mutants.
Nociceptive stimuli responses at different levels of general anaesthesia and genetic variability

Changes in skin conductance (SC), clinical stress score (CSS), the bispectral index spectroscopy (BIS) index and the variation in the BIS index may be used to monitor responses to nociceptive stimuli. We wanted to examine these methods during noxious stimulation during general anaesthesia and if the responses were associated with variability in genes related to pain.
On Additional Credit Spreads Caused by Jump Risks of the Default Rate

This paper studies credit spreads when the default intensity is affected by jump risks. A simple pricing model of risky bonds is derived using a reduced-form approach when there are jump risks of the factors of the default intensity, as supported by empirical evidence. Numerical analyses show that the additional credit spreads caused by jumps can be significant. ∗aDepartment of Business Administration & Accounting, Sejong University, 98 Gunja-Dong, GwangjinGu. Graduate School of Management, Korea Advanced Institute of Science and Technology, 207-43 Cheongryangni-Dong, Dongdaemun-Gu, Seoul, Korea. Tel. : +82-2-958-3693; Fax: +82-2-958-3421; E-mail address: cmahn@sejong.ac.kr (Chang Mo Ahn); jkkang@kgsm.kaist. ac.kr (Jangkoo Kang); fstar@kgsm.kaist. ac.kr (Hwa-Sung, Kim).
Solid-state NMR Study Reveals Collagen I Structural Modifications of Amino Acid Side Chains upon Fibrillogenesis*

Background: Collagen fibrillogenesis is a fundamental process both in vivo and in vitro. Results: Fibrillogenesis increases the heterogeneity of conformations of side chain amino acids, impacting 40% of imino acids. Conclusion: A temperature-induced-attractive force component comes from significant amount of the collagen amino acids. Significance: This work brings new perspectives to studies of collagen assembly and interactions with other matrix molecules. In vivo, collagen I, the major structural protein in human body, is found assembled into fibrils. In the present work, we study a high concentrated collagen sample in its soluble, fibrillar, and denatured states using one and two dimensional {1H}-13C solid-state NMR spectroscopy. We interpret 13C chemical shift variations in terms of dihedral angle conformation changes. Our data show that fibrillogenesis increases the side chain and backbone structural complexity. Nevertheless, only three to five rotameric equilibria are found for each amino acid residue, indicating a relatively low structural heterogeneity of collagen upon fibrillogenesis. Using side chain statistical data, we calculate equilibrium constants for a great number of amino acid residues. Moreover, based on a 13C quantitative spectrum, we estimate the percentage of residues implicated in each equilibrium. Our data indicate that fibril formation greatly affects hydroxyproline and proline prolyl pucker ring conformation. Finally, we discuss the implication of these structural data and propose a model in which the attractive force of fibrillogenesis comes from a structural reorganization of 10 to 15% of the amino acids. These results allow us to further understand the self-assembling process and fibrillar structure of collagen.
Multiport Converters Based on Integration of Full-Bridge and Bidirectional DC–DC Topologies for Renewable Generation Systems

A systematic method for deriving multiport converters (MPCs) from the full bridge (FB) converter (FBC) and bidirectional dc-dc converters (BDCs) is proposed in this paper through sharing the parasitized switching legs by the BDCs and the FBC. By employing the proposed method, families of FB and BDC-based MPCs (FB-BDC-MPCs), including some existing ones, are developed for renewable generation systems with the merits of simple topology, reduced devices, and single-stage power conversion. Voltage regulations between any two ports can be achieved by employing pulsewidth modulation and phase-angle-shift control scheme. Furthermore, zero-voltage switching for all the switches can be realized in the proposed FB-BDC-MPCs. A typical four-port converter developed by the proposed method, named buck/boost four-port converter (BB-FPC), is analyzed in detail as an example in terms of operation principles, design considerations, and control strategy. Experiments have been carried out on a 500-W prototype of BB-FPC, which demonstrate the feasibility and effectiveness of the proposed topology derivation method.
Open learning optimization based on cloud technology: Case study implementation in personalization e-learning

Indonesia is a developing country that began to utilize information technology in education. A form of its implementation is the use of e-learning. However, in practice there are still some obstacles, such as learning resources are not evenly distributed, limited access to services provided, qualified educators resources are concentrated in specific areas. This led to the emergence of disparities educational process, and technology gap due to differences in ICT infrastructure owned by any educational institution. Therefore this study propose an architecture of cloud-based open learning to solve these problems. The term open learning is used in order to encouraging the development of the concept of Indonesia Open Educational Resources (IOER) and as well as the adoption of concept of cloud computing. This research through several phases of research including analysis, design, implementation, testing and evaluation. The design of the proposed architecture consists of six layers: (1) Infrastructure, (2) Platform, (3) Application, (4) Service, (5) Access, (6) User. As a results of the implementation from this architecture is a prototype of Indonesia - Virtual Open Learning System (iVOLS). In experiment, personalization e-learning runs as a service that need large storage and other shared facilities to conduct the program so the system can delivered different learning materials to different learners. The personalization e-learning in cloud environment successed when the learners got the best performance on learning and it shown by their evaluation score. Based on the test results and evaluation showed that the availability on Cloud-Based Open Learning further meet user needs. This is indicated by the presence of a simple infrastructure services, application services with just one stage and the availability of a wider range of data and the resource sharing. In accessibility, Cloud-Based Open Learning provides easy access to the user. By economically, the result of evaluation showed that Cloud-Based Open Learning has an investment of 35.61% efficiency, increase return on investment (ROI) of 60.95% and an increase in benefits (NPV) of 81.97% from the user's perspective. While from the provider's perspective, Cloud-Based Open Learning has an investment of 200% efficiency, increase return on investment (Rol) of 220.4% and an increase in benefits (NPV) of 109.55%.
Les transformations du travail à l’ère du numérique et de l’« économie collaborative » : pistes d’analyse et de réflexion

L’émergence des plateformes numériques change fondamentalement la nature du travail, les façons de fonctionner des entreprises et l’organisation de l’activité productive, donnant naissance à ce qu’on appelle l’« économie collaborative ». Nous assistons, depuis quelques années, à l’émergence de grandes plateformes telles Uber, Airbnb ou Foodora, qui sont les plus connues; mais d’autres plateformes de service telles qu’Adèle sur demande émergent et sont présentes sur le territoire québécois. Que sait-on quant au nombre de ces plateformes et de leurs collaborateurs? Est-ce que l’ensemble de ces plateformes de services engendre les mêmes formes de travail? Les effets bénéfiques ou néfastes de ce type de travail sont-ils partagés par l’ensemble des travailleurs oeuvrant au sein d’une même plateforme? Partant de ces interrogations, le présent article propose une description réflexive et problématique des enjeux relatifs au travail dans le contexte de l’émergence de ce qu’on appelle l’« économie collaborative ». Dans un premier temps, nous examinons l’objet de recherche que sont les plateformes numériques en tant que nouvel acteur de l’économie contemporaine. Dans un deuxième temps, nous exposons les difficultés d’estimation et les limites d’analyse des nouvelles formes de travail effectuées par l’intermédiaire des plateformes. Dans un troisième temps, en tenant compte de l’état des études sur ce sujet, nous proposons des pistes de réflexion pour souligner la nécessité d’un programme de recherche interdisciplinaire sur ce phénomène en émergence.
Perceptions of health and their relationship to symptoms in African American women with type 2 diabetes.

Diabetes mellitus is an incurable disease and a major cause of mortality and morbidity. Diabetes disproportionately affects members of minorities who suffer from higher rates of complications and greater disability (Cowie & Eberhardt, 1996). The purpose of this study was to (a) describe the symptoms of African American women with Type 2 diabetes and examine the relationship among diabetes-related symptoms; (b) document complications of diabetes and perceptions of health and functioning; and (c) examine the relationship between duration of diabetes and age at diagnosis and perceived health. A convenience sample of 75 African American women with Type 2 diabetes were interviewed. A 44-item questionnaire measured selected demographic variables, symptoms, documented complications, and their perceived relationship to diabetes. The SF-20 was used to measure perceptions of health status. Data show that African American women with Type 2 diabetes have a wide variety of symptoms and poor perceptions of their general health and physical functioning.
Electrophysiological evidence for distinct vagal pathways mediating CCK‐evoked motor effects in the proximal versus distal stomach

Gut activity is controlled by the vagus nerves. In anaesthetized rats, both sensory and motor nerve activity evoked by intravenous injection of the gut hormone cholecystokinin were recorded in separate sub‐branches of the gastric vagus nerve that supply the forestomach and hindstomach, respectively. Activity in the forestomach branch has not been studied before. Motor nerve activity in response to cholecystokinin differed between the two branches, in both timing and direction. Motor output to the forestomach paralleled sensory input from the hindstomach, while motor output to the hindstomach paralleled sensory input from the intestines. The data suggest that cholecystokinin released in the intestines after a meal immediately influences churning and propulsion of food by the hindstomach, via reflexes initiated by nearby intestinal sensory nerve terminals, but may influence gastric capacity only later, once circulating levels of cholecystokinin rise to levels capable of activating sensors in the hindstomach.
Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes

Supplementation of 100% oxygen is a very common intervention in intensive care units (ICU) and critical care centers for patients with dysfunctional lung and lung disorders. Although there is advantage in delivering sufficient levels of oxygen, hyperoxia is reported to be directly associated with increasing in‐hospital deaths. Our previous studies reported ventricular and electrical remodeling in hyperoxia treated mouse hearts, and in this article, for the first time, we are investigating the effects of hyperoxia on atrial electrophysiology using whole‐cell patch‐clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real‐time quantitative RT‐PCR and Western blotting. Our data showed that induction of hyperoxia for 3 days in mice showed larger outward potassium currents with shorter action potential durations (APD). This increase in current densities is due to significant increase in ultrarapid delayed rectifier outward K+ currents (IKur) and rapidly activating, rapidly inactivating transient outward K+ current (Ito) densities. We also observed a significant increase in both transcripts and protein levels of Kv1.5 and KChIP2 in hyperoxia treated atrial cardiomyocytes, whereas no significant change was observed in Kv4.2 transcripts or protein. The data presented here further support our previous findings that hyperoxia induces not only ventricular remodeling, but also atrial electrical remodeling.
The Paradox of Realism and “Authenticity” in Entertainment-Education: A Study of Adolescents' Views About Anti-Drug Abuse Dramas

The successful use of drama as a vehicle to influence health-related attitudes and behaviors is credited to its ability to elicit an emotional experience and identification among audience members. This study investigated the views of adolescents regarding an entertainment-education (EE) component of their school's anti-drug program—a live performance of a professionally produced anti-drug abuse drama. The analysis draws mainly on data collected from 64 focus groups, conducted in 24 schools across Israel, and open-ended responses to questionnaires administered to more than 1,700 adolescents. The adolescents were generally entertained by the anti-drug abuse drama and moved by its “authenticity,” which emerged as a central construct in this study. Yet only a fraction identified with the characters and many remained unwilling to “tell” on a friend who uses drugs. Drawing on these findings, implications to EE theory and practice are discussed, particularly as they relate to the drama's perceived realism or “authenticity,” and its unintended effects.
The Impact of Temperament in a School Setting: An Epidemiological Study *

The authors present the results of an epidemiological study on a large non-clinical population-based sample of French speaking seven year-old children (N = 596) whose aim was to verify if a relation exists between temperament and outward-type or inward-type behavior problems in school. The Thomas and Chess’ Parent Temperament Questionnaire, filled out twice by the parents over a four-week interval, was used to determine temperament. The Conners Teacher Questionnaire, filled out twice by the teachers over a four-week interval, was used to determine behavior problems in school. Five points emerge from this study. First, “difficult” temperament ‘per se’ is not associated either with outward-type or inward-type behavior problems in school. Second, a temperamental pattern of high activity and high approach with new stimuli predisposes boys to present outward-type behavior problems in school. Third, the temperamental traits of low adaptability or withdrawal with new stimuli predisposes girls to inward-type behavior problems in school. Fourth, the study demonstrates the importance of verifying if the associations between temperament and behavior problems are stable since, in the comparisons between results of the test with those of the retest, several of the associations found in one occasion failed to be replicated at the other. Fifth, the different influences of temperament according to sex emphasize the need to study boys and girls separately. Future studies should take into account interactions between parents/teachers and child temperament since these sex-related different influences of temperament could be related to the sex-related different attitudes of caretakers.
Perceptions et attitudes des femmes jeunes vis-à-vis du risque cardio-vasculaire : étude qualitative auprès de femmes du bassin lorientais en prévention primaire

Contexte : Les femmes, meme avant 60 ans, ne sont plus epargnees par les maladies cardio-vasculaires (MCV). Les specificites du risque cardio-vasculaire (RCV) feminin sont de plus en plus etudiees, mais qu’en pensent les femmes elles-memes ? L’objectif de cette etude etait d’explorer les perceptions et attitudes des femmes jeunes vis-a-vis du risque cardio-vasculaire. Methode : Une etude qualitative, par entretiens individuels semi-diriges, a ete menee, de mars a octobre 2016, aupres de femmes de moins de 60 ans, a risque cardio-vasculaire, en prevention primaire. Une analyse thematique manuelle avec double codage a ete realisee. Resultats : Huit entretiens ont ete analyses. Les femmes interrogees eprouvaient des difficultes a s’approprier leurs facteurs de risque cardio-vasculaire (FDRCV), percus comme asymptomatiques, chroniques, stabilises, et peu modifiables. Leurs representations des MCV etaient pertinentes mais le RCV etait relativise par la plupart des interrogees, invoquant son caractere potentiel et lointain. Elles avaient conscience des mesures preventives a entreprendre pour limiter leur RCV mais de nombreux obstacles empechaient leur mise en œuvre. Elles ont mis en doute l’efficacite des actions preventives, percues comme complexes, contraignantes, et peu compatibles avec leur rythme de vie familial et professionnel. L’entourage etait une source privilegiee d’information et vecteur de leurs representations des MCV. Le medecin generaliste etait percu comme coordinateur du suivi. Elles appreciaient son attitude comprehensive et sa capacite a les rassurer. En revanche, il n’etait pas une source d’informations et elles ne percevaient pas toujours son role preventif. Conclusion : Ces femmes jeunes, a RCV, ont une vision medicalement coherente des MCV mais relativisent leur propre risque, retardant ainsi la mise en œuvre des changements preventifs. Nous devons ameliorer nos strategies de communication du RCV vis-a-vis de ces femmes ; reaffirmer l’impact du mode de vie sur leurs FDRCV, leur accorder des temps de prevention dedies et developper des campagnes d’informations ciblees.