Miracle-dz/UniFAR-FTUs huggingface dataset:
Microenvironmental Regulation of Membrane Type 1 Matrix Metalloproteinase Activity in Ovarian Carcinoma Cells via Collagen-induced EGR1 Expression*

Late stage ovarian cancer is characterized by disseminated intraperitoneal metastasis as secondary lesions anchor in the type I and III collagen-rich submesothelial matrix. Ovarian carcinoma cells preferentially adhere to interstitial collagen, and collagen-induced integrin clustering up-regulates the expression of the transmembrane collagenase membrane type 1 matrix metalloproteinase (MT1-MMP). Collagenolytic activity is important in intraperitoneal metastasis, potentiating invasion through the mesothelial cell layer and colonization of the submesothelial collagen-rich matrix. The objective of this study was to elucidate a potential mechanistic link between collagen adhesion and MT1-MMP expression. Our results indicate that culturing cells on three-dimensional collagen gels, but not thin layer collagen or synthetic threedimensional hydrogels, results in rapid induction of the transcription factor EGR1. Integrin signaling through a SRC kinase-dependent pathway is necessary for EGR1 induction. Silencing of EGR1 expression using small interfering RNA abrogated collagen-induced MT1-MMP expression and inhibited cellular invasion of three-dimensional collagen gels. These data support a model for intraperitoneal metastasis wherein collagen adhesion and clustering of collagen binding integrins activates integrin-mediated signaling via SRC kinases to induce expression of EGR1, resulting in transcriptional activation of the MT1-MMP promoter and subsequent MT1-MMP-catalyzed collagen invasion. This model highlights the role of unique interactions between ovarian carcinoma cells and interstitial collagens in the ovarian tumor microenvironment in inducing gene expression changes that potentiate intraperitoneal metastatic progression.
Underdiagnosis of peripheral neuropathy in type 2 diabetes.

Diabetic peripheral neuropathy and its late sequelae cost >$4 billion annually in the U.S. (1). Improved glycemic control, early detection, and preventive care can prevent or delay adverse outcomes (2–4). An annual foot exam, which may include monofilament testing, is recommended by the American Diabetes Association (5). Unfortunately, neuropathy screening is underutilized in primary care practice (6,7). The GOAL A1C (Glycemic Optimization with Algorithms and Labs At Po1nt of Care) study assessed methods of A1C testing and insulin titration monitoring strategies in a large nationwide sample of predominantly primary care patients with type 2 diabetes. At baseline, physician perception of the presence of neuropathy was assessed via a survey before monofilament testing. A comparison between physician perception and monofilament testing is reported. GOAL A1C was a randomized, open-label, parallel, four-arm study that compared the impact of point of care versus laboratory A1C testing and weekly versus less frequent insulin titration monitoring on glycemic control in patients with type 2 diabetes adding insulin glargine to existing oral antidiabetic therapy. Eligible patients were aged ≥18 years, inadequately controlled on oral antidiabetic agents (A1C >7.0%), and candidates for insulin. All signed informed consent …
The repopulation of irradiated bone marrow by the infusion of stored autologous marrow.

Midplane doses of 4,000 rads were delivered to 8 dogs in four weeks, after which 4 animals were reinfused with stored autologous marrow while the remaining 4 served as controls. Peripheral blood counts, marrow aspirations, and serial 99mTc marrow photoscans did not demonstrate any detectable difference in the two groups.
The Farnesyltransferase Inhibitor L744832 Potentiates UCN-01–Induced Apoptosis in Human Multiple Myeloma Cells

Purpose: The purpose of this study was to characterize interactions between the farnesyltransferase inhibitor L744832 and the checkpoint abrogator UCN-01 in drug-sensitive and drug-resistant human myeloma cell lines and primary CD138+ multiple myeloma cells. Experimental Design: Wild-type and drug-resistant myeloma cell lines were exposed to UCN-01 ± L744832 for 24 hours, after which mitochondrial injury, caspase activation, apoptosis, and various perturbations in signaling and survival pathways were monitored. Results: Simultaneous exposure of myeloma cells to marginally toxic concentrations of L744832 and UCN-01 resulted in a synergistic induction of mitochondrial damage, caspase activation, and apoptosis, associated with activation of p34cdc2 and c-Jun-NH2-kinase and inactivation of extracellular signal-regulated kinase, Akt, GSK-3, p70S6K, and signal transducers and activators of transcription 3 (STAT3). Enhanced lethality for the combination was also observed in primary CD138+ myeloma cells, but not in their CD138− counterparts. L744832/UCN-01–mediated lethality was not attenuated by conventional resistance mechanisms to cytotoxic drugs (e.g., melphalan or dexamethasone), addition of exogenous interleukin-6 or insulin-like growth factor-I, or the presence of stromal cells. In contrast, enforced activation of STAT3 significantly protected myeloma cells from L744832/UCN-01–induced apoptosis. Conclusions: Coadministration of the farnesyltransferase inhibitor L744832 promotes UCN-01–induced apoptosis in human multiple myeloma cells through a process that may involve perturbations in various survival signaling pathways, including extracellular signal-regulated kinase, Akt, and STAT3, and through a process capable of circumventing conventional modes of myeloma cell resistance, including growth factor– and stromal cell–related mechanisms. They also raise the possibility that combined treatment with farnesyltransferase inhibitors and UCN-01 could represent a novel therapeutic strategy in multiple myeloma.
Comparison of three current staging systems for hepatocellular carcinoma: Japan integrated staging score, new Barcelona Clinic Liver Cancer staging classification, and Tokyo score

Background and Aim: Although various staging systems for hepatocellular carcinoma (HCC) have been developed in recent years, there is no worldwide consensus which staging system is best. The aim of the present study was to compare the performance of the currently developed three staging systems: the Japan integrated staging (JIS) score, new Barcelona Clinic Liver Cancer (BCLC) staging classification, and the Tokyo score.
Axonal neurofilament‐H immunolabeling in the rabbit retina

A monoclonal antibody directed at the multiphosphorylated epitope of axonal neurofilament‐H (NF‐H) was used to label axon‐like fibers in the rabbit retina. NF‐H‐immunopositive fibers were found in the outer plexiform layer (OPL), inner plexiform layer (IPL), and optic fiber layer (OFL). The morphological characteristics of the labeled processes identified those in the OPL as horizontal cell axons and axon terminals and fibers in the OFL as axons of ganglion cells. The NF‐H‐positive profiles in the OPL formed a subset of horizontal cell processes labeled for calbindin. In the IPL, NF‐H‐immunoreactive profiles lay at all levels but were detected most often in the middle strata, 2–4. Occasionally, we observed NF‐H‐immuoreactive processes emerging from the IPL and entering either the GCL or the inner nuclear layer (INL). The labeled fibers in the IPL were typically very thin, less than 1 μm in diameter, and could often be followed for over 1 mm as they ran laterally across the retina. Cell bodies were never labeled by the immunoserum. To identify the NF‐H‐immunopositive fibers in the IPL, standard immunocytochemical double‐labeling techniques were applied, using antibodies directed against several neurotransmitters or modulators thought to be expressed by axon‐bearing amacrine cells. The NF‐H‐positive processes in the IPL were found to correspond to those labeled for tyrosine hydroxylase, somatostatin, substance P, and NADPH diaphorase activity. However, the NF‐H labels did not colocalize with those against the vasoactive intestinal peptide‐associated protein PHM27. Our results indicate that putative axons in the retina possess the multiphosphorylated NF‐H protein found within classic axons in the central nervous system. These results thus support the idea that certain subtypes of amacrine and horizontal cells maintain true axons in the mammalian retina. J. Comp. Neurol. 453:269–279, 2002. © 2002 Wiley‐Liss, Inc.
Probabilistic information retrieval in a distributed heterogeneous environment

This thesis describes a probabilistic model for optimum information retrieval in a distributed heterogeneous environment. The model assumes the collection of documents o ered by the environment to be hierarchically partitioned into subcollections. Documents as well as subcollections have to be indexed. At this, indexing methods using di erent indexing vocabularies can be employed. A query provided by a user is answered in terms of a ranked list of documents. The model determines a procedure for ranking the documents that stems from the Probability Ranking Principle: For each subcollection, the subcollection's elements are ranked; the resulting ranked lists are combined into a nal ranked list of documents, where the ordering is determined by the documents' probabilities of being relevant with respect to the user's query. Various probabilistic ranking methods may be involved in the distributed ranking process. The underlying data volume is arbitrarily scalable. A criterion for e ectively limiting the ranking process to a subset of subcollections extends the model. The model's applicability is experimentally con rmed. When exploiting the degrees of freedom provided by the model, experiments showed evidence that the model even outperforms comparable models for the non-distributed case with respect to retrieval e ectiveness. An architecture for a distributed information retrieval system is presented that realizes the probabilistic model. The system provides access to an arbitrary number of dynamic multimedia databases.
Parametric Surfaces

I want first to express my thanks to the Presidium of the American Mathematical Society for the invitation to deliver an address to the Society. I feel very much honored by this invitation and I appreciate it highly. My address will be devoted to parametric surfaces, to that part of the subject which is connected with the definition of the area, with the expression of the area by an integral, and with the minimum area problem. It is an exceptional privilege to lecture on this subject to the American Mathematical Society, whose members have been responsible for such an impressive progress of the subject during the last two decades. I shall start with the definition of the area. In 1914 Carathéodory defined the ra-dimensional measure in the «-dimensional space, for integral values of m. He considered the one-dimensional measure as a generalization of the length and he proved that the length of a rectifiable curve coincides with its onedimensional measure. In 1919, Hausdorff, developing Caratheodory's ideas, constructed a continuous scale of measures. After the work of Carathéodory and Hausdorff the obvious problem was to treat the area as the two-dimensional measure and to establish the well known integral formulae. But a considerable amount of work on establishing the integral formulae for the area had been done before that, with a variety of definitions of the area, due no doubt to the difficulty of the problem. Later the Lebesgue definition, somewhat modified by Frechet, of the area as the lower limit of areas of approximating polyhedra became the dominant one. A particularly valuable feature of the LebesgueFrechet (L.-F.) definition is that it provides the area with the property of the lower semi-continuity. When applied to plane figures bounded by a Jordan curve the L. -F. definition gives in fact the value of the interior area of the figure, and thus in cases when the boundary is of positive L2-measure, the L. -F. area differs from the value of the closed area in the usual
SK-languages as a Powerful and Flexible Semantic Formalism for the Systems of Cross-Lingual Intelligent Information Access

The first starting point of this paper is the broadly accepted idea of employing, as a promising methodology, an artificial semantic language-intermediary for the realization of automatic cross-lingual intelligent information access to natural language (NL) texts on the Web. The second one is the emergence in computational semantics during 2013-2016 of great interest in the semantic formalism (more exactly, notation) called Abstract Meaning Representation (AMR). This formalism was introduced in 2013 in an ACL publication by a group consisting of ten researchers from UK and USA. This paper shows that much broader prospects for creating semantic languages-intermediaries in comparison with AMR are opened by the theory of K-representations (TKR), developed by V. A. Fomichov. The basic mathematical model of TKR describes the regularities of NL structured meanings. The mathematical essence is that this model introduces a system consisting of ten partial operations on conceptual structures. Initial version of this model was published in 1996 in Informatica (Slovenia). The second version of the model (stated in a monograph released by Springer in 2010) defines a class of formal languages called SK-languages (standard knowledge languages). It is demonstrated that SK-languages allow us to simulate all expressive mechanisms of AMR. The advantages in comparison with AMR are, in particular, the possibilities to construct semantic representations of compound infinitive constructions (expressing goals, commitments, etc), of compound descriptions of notions and sets, and of complex discourses and knowledge pieces.
Osteonecrosis of the Jaw: A Case Report and a Critical Review of Surgical Management

Osteonecrosis of the jaw (ONJ) is a relatively rare but serious complication of bisphosphonates (and denosumab) therapy for which conservative or surgical treatment is advocated. We report an exemplative case and review recently published studies of surgical management of ONJ. The total population surveyed in those 7 studies included 1459 patients. Operative treatment was applied in 53-100% of the patients and non-operative treatment in 0-47%. Response after surgery was seen in 59-87% (actually 938 patients out of 1204-77% - responded). Non-operative treatment was successful in 20-100% (40 out of 250 – 16% - patients responded). The highest range of response was seen in stage 2 diseases (22-67%). Our review supports the use of a relatively early surgical approach in the management of ONJ.
EQUIDADE: APONTAMENTOS PARA A EDUCAÇÃO DO CORPO

O proposito da exposicao e analisar o desenvolvimento historico da ideia de igualdade e seus desdobramentos em politicas de equidade. Durante a estruturacao e desenvolvimento da sociedade capitalista, observa-se a tensao historica pela igualdade substantiva e as elaboracoes cientificas e politicas para viabilizar um sentido de igualdade subjetiva, fundado em bases biologicas, a partir da qual se forma o individuo que tem na sua constituicao corporal, a igualdade que lhe garante participacao social. Hodiernamente, as politicas de equidade dao continuidade ao sentido historico de igualdade proposto pela sociedade capitalista, ao eleger a diferenca como principio capaz de realizar a efetiva igualdade de oportunidades.
Intra-organizational Communication in Healthcare

Summary Objectives: Intra-organizational communication is mostly interpersonal. Synchronous interruptive communication is recognized as aprimary source of inefficiency anderror in healthcare, and there is much potential for information and communication technology (ICT) to improve such communication. As recently suggested, however, due to communication failures ICT can also compound medical errors. In this paper we analyze factors that restrict the role of ICT in improving interpersonal healthcare communication and suggest solutions. Methods: We critically analyzed the literature from a selection of diverse scientific disciplines. These were related to interpersonal communication, tothe role and place of standardization and computerization in its improvement, and to reducing medical errors. Results: Four possible scenarios were defined on how ICT can serve healthcare communication. Two differing conceptual frameworks about communication in health-care were discussed. Considering “information space” as apart of “communication space ” allows the recognition and control of the source of the semantic gaps in conventional standardization and an enhancement of the role of ICT in improving intra-organizational communication. Moreover, cognitive, social, and organizational dimensions of complexity in interpersonal communication can be managed. Three approaches to control the variability in those dimensions and to promote therole of ICT in intra-organizational communication were discussed. Conclusion: A multi-dimensional approach is required to promote the role of ICT in intra-organizational communication in healthcare. Parallel to conventional standardization, atleast three dimensions need to be addressed: controlling the effect of the social context, developing standard information processing skills, and most importantly, controlling variations in care practices’ performance.
A fully integrated 70 GHz SiGe low phase noise push-push oscillator

This paper describes a fully monolithically integrated push-push oscillator fabricated in a production-near SiGe:C bipolar technology. The transistors used in this work show a maximum transit frequency f/sub T/ = 200 GHz and a maximum frequency of oscillation f/sub max/ = 275 GHz. For the passive circuitry transmission-line components, integrated spiral inductors and MIM-capacitors are used. The oscillator output frequency can be tuned from 63 GHz to 72 GHz. In this frequency range the output power varies between -1.8 dBm and +1.6 dBm while the measured single sideband phase noise is less than -103dBc/Hz at 1MHz offset frequency. To our knowledge this phase noise level is the lowest one reported in literature so far for an integrated oscillator in this frequency band.
Cortisone as a probe for cell interactions in the generation of cytotoxic T cells. I. Effect on helper cells, cytotoxic T cell precursors, and accessory cells.

The effect of cortisone on the in vitro cell-mediated cytotoxic response was investigated with respect to the participating cell types, viz., the cytotoxic T cell precursor (CTP), the helper cell, and the accessory (A) cell. Spleen and thymus cells from cortisone-treated CBA/CaJ mice were unable to generate alloreactive cytotoxic T cells when cultured with semiallogeneic (CBA/CaJ × DBA/2JF1) spleen cells or allogeneic (P815) tumor cells. This immunosuppression could be reversed by the addition of 2-Me to the cultures, which suggests that the CTP and helper cells were present but unresponsive. Measurements of the CTP frequency and helper activity in cultures containing 2-Me confirmed this possibility. Thus, limiting dilution analysis of spleen and thymus cells from cortisone-treated mice showed that they contained higher frequencies of CTP than cells from normal mice. Helper cell activity, as measured by the secretion of helper factor by primed cells, was found to be higher after cortisone treatment. The possibility of a defect in A cell function in spleen cells of cortisone-treated mice was suggested by 1) the ability of irradiated peritoneal macrophages to reconstitute the response, and 2) the greatly reduced efficiency of irradiated spleen cells (adherent or nonadherent) from cortisone-treated mice to restore responsiveness to nonadherent, A cell-deficient normal spleen cells. Although cortisone may exert its immunosuppressive effect on helper cells and CTP directly, it is likely that the deficiency in A cell function is at least partially responsible for the unresponsiveness of cortisone-treated cells.
Study on a sparse antenna array for terahertz imaging

This paper presents our study on a sparse antenna array for 0.22 THz imaging. Based on the effective aperture concept for the design of sparse antenna array, two schemes for high performance THz imaging of a target at distance of 1 m have been achieved in simulation. Then, different schemes of larger array element spacing and mechanical scanning spacing have been investigated to build the relationship between their configurations and imaging performance. Based on the study, it is predicted theoretically and from the reconstructed images that only 16 transmitting and 16 receiving antennas will be sufficient to scan a 2.0 m ∗ 0.8 m target. And the spatial resolution of 4.44 mm at 5 m is potentially achieved. Therefore, this study will provide a valuable guideline for the following sparse array design in a high performance THz imaging system.
Prenatal detection of 5q14.3 duplication including MEF2C and brain phenotype

The 5q14.3 duplication is a rare condition comprising speech and developmental delay, microcephaly, and mild ventriculomegaly. The region 5q14.3 contains several genes but the predominant role for the onset of the neurodevelopmental phenotype has been attributed to MEF2C. We describe the prenatal identification of 5q14.3 duplication, including MEF2C, in a monochorionic twin pregnancy with corpus callosum anomalies, confirmed by autopsy. To the best of our knowledge, this cerebral finding has been observed for the first time in 5q14.3 duplication patients, possibly widening the neurological picture of this scarcely known syndrome. A pathogenetic role of MEF2C overexpression in brain development may be assumed, but further studies are needed. © 2016 Wiley Periodicals, Inc.
A PFC based SRM motor drive using a canonical switching cell converter

In this paper, a canonical switching cell (CSC) converter is proposed as a front end converter for power factor correction in a switch reluctance motor (SRM) drive. Aiming at low power household applications, SRM has demonstrated as one of the finest selection. On the selection part buck boost converter serves the best results when controlled output voltage is required over wide range. The speed of SRM is controlled by varying the DC-bus voltage appearing across the midpoint converter which is used to drive a 4-phase SRM. The proposed CSC converter working in discontinuous inductor current mode is used to control the DC output voltage and to improve the power quality at the AC mains. Total harmonic distortion (THD) at AC mains current when SRM is fed by diode bridge rectifier is observed 70% to 80%. Which is brought down to <;5% as per the IEEE-519 standard.
Mycobacterial Infection in TLR2 and TLR6 Knockout Mice

To investigate the role of TLR in the development of murine tuberculosis in vivo, TLR2 and TLR6 knockout (KO) mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne infection apparatus. Both TLR2 and TLR6 KO mice survived until sacrifice at 12 weeks after infection. Infected TLR2 KO mice developed granulomatous pulmonary lesions with neutrophil infiltration, which were slightly larger in size than those in wild‐type mice. Pulmonary levels of the mRNAs for inducible nitric oxide synthase (iNOS), TNF‐α, TGF‐β, IL‐1β, and IL‐2 were significantly lower, but levels of the mRNAs for IL‐4 and IL‐6 were higher, than in wild‐type (WT) mice. No significant difference was recognized in cytokine mRNA expression between TLR2 KO and WT mice at 12 weeks after infection. DNA binding by NF‐κB was low in TLR2 KO mice. On the other hand, TLR6 KO mice were not different from WT mice in terms of pulmonary histopathology, mRNA expression and CFU assay. Therefore, TLR2 does not play an essential role in the pathogenesis of murine tuberculosis, although it is important for defense against mycobacterial infection.