Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects

Purpose A new fixed-dose combination (FDC) formulation of 120 mg fimasartan and 20 mg rosuvastatin was developed to increase therapeutic convenience and improve treatment compliance. Methods A randomized, open-label, single-dose, two-treatment, two-way crossover study with a 7-day washout period was conducted to compare the pharmacokinetic (PK) characteristics and bioequivalence between an FDC of fimasartan/rosuvastatin and the separate co-administration of fimasartan and rosuvastatin in healthy Korean volunteers. The plasma concentrations of fimasartan and rosuvastatin were analyzed by a validated liquid chromatography-tandem mass spectrometry method, for which serial blood samples were collected for up to 48 hours post-administration of fimasartan and 72 hours post-administration of rosuvastatin, in each period. The PK parameters were calculated using a non-compartmental method. Results A total of 78 subjects completed the study. All the 90% CIs of the geometric mean ratios (GMRs) fell within the predetermined acceptance range. The GMR and 90% CI for the area under the plasma concentration-time curve from time 0 to the last measurement (AUC0–t) and the maximum plasma concentration (Cmax) for fimasartan were 0.9999 (0.9391–1.0646) and 1.0399 (0.8665–1.2479), respectively. The GMR and 90% CI for the AUC0–t and Cmax for rosuvastatin were 1.0075 (0.9468–1.0722) and 1.0856 (0.9944–1.1852), respectively. Treatment with fimasartan and rosuvastatin was generally well tolerated without serious adverse events. Conclusion The new FDC formulation of 120 mg fimasartan and 20 mg rosuvastatin can be substituted for the separate co-administration of fimasartan and rosuvastatin, for the advantage of better compliance with convenient therapeutic administration.
A Portable 3×3 Mueller Matrix Polarimeter Prototype for Cancer Detection Ex Vivo

In this paper, a new structure of polarimeter is designed to measure the 3×3 Mueller matrix of ex-vivo human tissues by integrating the polarization state generator (PSG) and the polarization state analyzer (PSA) together in a metal base. The rotation of linear polarizers was implemented precisely and rapidly by two DC servo motors, and controlled along with the snapshots of the polarimetric images by a software program running on a mobile work station. Hence, the whole system is portable and the total acquisition time for a Mueller matrix was controlled within 5 seconds. Furthermore, the Z pulse output of the encoder was utilized to search the horizontal axis of linear polarizers, which was taken as an automatic calibration tool after the system being moved out of the laboratory for measurement. Finally, a prototype was implemented and validated with a linear polarizer and chicken heart cross-section. This prototype was then moved to Shenzhen Second People's Hospital for the measurement of unstained human tissue samples that were treated only with fixatives. The comparison between the pathological results and the Mueller matrix parameters showed the potential application of our system in cancer detection.
Spinal Cord-derived Neural Precursor Cells as a Preventive Therapy for Spinal Cord Injury

Background: Spinal cord injury (SCI) as one of the most important diseases of central nervous system (CNS) without any definite treatment is still growing in incidence. In addition to trauma, some surgeries such as cardiac and thoracic aorta surgery may result in SCI as a complication. In last years, a promising approach has shed light on this CNS injury thanks to stem cell technology. Stem cell therapy could be considered as a good candidate for transplantation and enhancing neural regeneration in SCI. In this study, we identified the effects of spinal cord-derived neural precursor cells (NPCs) transplantation on SCI in after and before injury injection. Materials and Methods: NPCs were isolated from the adult rat spinal cord and cultured in vitro using complete culture media. After neurosphere formation, the cells were differentiated to neurons, oligodendrocytes, and astrocyte. The cells were transplanted to the rat model of SCI in 1 day before and 1 day after injury. The animals were followed for 12 weeks to assess their neurological performance. In addition, histological study and inflammatory cytokines levels have been studied. Results: Our results indicate that NPCs infusion both pre- and post-SCI could decrease the level of inflammatory cytokines. In addition, the neurological performance and histologic studies showed recovery after this type of injury using NPCs, and it might be due to inflammation modulatory effects on neural stem cells. Conclusion: NPCs therapy for SCI in both two-time points (before and after SCI) could be beneficial and make a neurological recovery. In other words, NPCs therapy could be considered as a therapeutic and also preventive approach for SCI.
Desarrollo y validación experimental de una metodología para estudiar la propagación de grietas por fatiga en metales

The existence and propagation of cracks in structures and components is a challenge for industrial sectors such as oil & gas, wind or nuclear. The present study summarizes the research carried out to develop and validate a procedure, based on the finite element method, able to simulate the propagation of three-dimensional cracks. This research comprises an experimental part where the fatigue crack propagation rate of the grade R5 steel, widely used in offshore mooring chains, has been characterized. For this purpose, the Paris Law of the material has been determined by testing a three point bending specimen. Furthermore, a statistical study to estimate the uncertainty in the crack propagation rate was carried out. The experimental results have been used as inputs for the numerical model developed in ANSYS APDL. This algorithm allows numerical evaluating the fracture mechanics parameters in the crack front during its growth. This information feedbacks an iterative algorithm that provides the crack front growth. Finally, a sensitivity study was carried out to evaluate the effect of the meshing size on the results.
A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody

Human parechovirus 3 (HPeV3) is receiving increasing attention as a prevalent cause of sepsis-like symptoms in neonates, for which, despite the severity of disease, there are no effective treatments available. Structural and molecular insights into virus neutralization are urgently needed, especially as clinical cases are on the rise. Toward this goal, we present the first structure of HPeV3 in complex with fragments from a neutralizing monoclonal antibody. At high resolution, it was possible to precisely define the epitope that, when targeted, prevents virions from binding to cells. Such an atomic-level description is useful for understanding host-pathogen interactions and viral pathogenesis mechanisms and for finding potential cures for infection and disease. ABSTRACT Human parechovirus 3 (HPeV3) infection is associated with sepsis characterized by significant immune activation and subsequent tissue damage in neonates. Strategies to limit infection have been unsuccessful due to inadequate molecular diagnostic tools for early detection and the lack of a vaccine or specific antiviral therapy. Toward the latter, we present a 2.8-Å-resolution structure of HPeV3 in complex with fragments from a neutralizing human monoclonal antibody, AT12-015, using cryo-electron microscopy (cryo-EM) and image reconstruction. Modeling revealed that the epitope extends across neighboring asymmetric units with contributions from capsid proteins VP0, VP1, and VP3. Antibody decoration was found to block binding of HPeV3 to cultured cells. Additionally, at high resolution, it was possible to model a stretch of RNA inside the virion and, from this, identify the key features that drive and stabilize protein-RNA association during assembly. IMPORTANCE Human parechovirus 3 (HPeV3) is receiving increasing attention as a prevalent cause of sepsis-like symptoms in neonates, for which, despite the severity of disease, there are no effective treatments available. Structural and molecular insights into virus neutralization are urgently needed, especially as clinical cases are on the rise. Toward this goal, we present the first structure of HPeV3 in complex with fragments from a neutralizing monoclonal antibody. At high resolution, it was possible to precisely define the epitope that, when targeted, prevents virions from binding to cells. Such an atomic-level description is useful for understanding host-pathogen interactions and viral pathogenesis mechanisms and for finding potential cures for infection and disease.
Relating Aesthetics of the GUI Text Elements with Readability using Font Family

Although, a number of works were reported on the readability of the text elements present in digital as well as the printed media, aesthetics of the text elements were ignored till date. In this work, the effect font family on text aesthetics, and readability is reported. Forty text based interfaces were designed by using different fonts; half of them were serif fonts, and the rest were sans-serif fonts. The interfaces were rated based on the aesthetic appeal on a five-point rating scale by a group of forty participants. The reading times were recorded to identify the effect of readability with the font families. Based on the empirical data, two one-dimensional ANOVA were carried out on the aesthetics, and readability respectively. Experimental results showed that font family is a statistically significant feature for both the readability and aesthetics. In order to establish the relation of the readability with aesthetics, the average users' rating and average reading time were considered as the final ratings for all the forty interfaces. It was observed that the texts with better aesthetics generally improves the readability.
Software Reliability Evaluation Method Based on a Software Network

This paper proposes a method for the comprehensive measurement of software quality and reliability based on the complex network theory. The quality of the overall network structure of software is evaluated in terms of modularity, hierarchy, complexity, and fault propagation. The importance and reliability risks of the software module are combined to evaluate the overall reliability risk of software. According to the historical defect information of software, the characteristics of the defect node are analyzed to predict the software's current version of the high defect risk module. The software reliability level is comprehensively evaluated by combining the software's overall structural quality, reliability risk and defect risk.
Weakly Supervised Soft-detection-based Aggregation Method for Image Retrieval

In recent year, the compact representations based on activations of Convolutional Neural Network (CNN) achieve remarkable performance in image retrieval. Some interested object only takes up a small part of the whole image. Therefore, it is significant to extract the discriminative representations that contain regional information of pivotal small object. In this paper, we propose a novel weakly supervised soft-detection-based aggregation (SDA) method free from bounding box annotations for image retrieval. In order to highlight the certain discriminative pattern of objects and suppress the noise of background, we employ trainable soft region proposals that indicate the probability of interested object and reflect the significance of candidate regions. We conduct comprehensive experiments on standard image retrieval datasets. Our weakly supervised SDA method achieves state-of-the-art performance on most benchmarks. The results demonstrate that the proposed SDA method is effective for image retrieval.
The role of spatial store and executive strategy in spatial working memory: a comparison between patients with obsessive–compulsive disorder and controls

ABSTRACT Introduction: Patients with obsessive–compulsive disorder (OCD) showed impaired spatial working memory (SWM). We evaluated whether patients and healthy controls (HCs) differed in spatial store capacity, and whether they differed in the relative weight of spatial store capacity and/or executive strategy in SWM. Methods: Thirty inpatients with OCD and 31 age- and education-matched HCs underwent the CANTAB SWM, SRM (a measure of spatial store). The severity of OC symptoms was assessed using the Y-BOCS. Statistical significance: α = 0.05. Results: Patients showed poorer performance than HCs in all neuropsychological outcomes. Both poorer SRM and SWM strategy were significantly associated with poorer SWM in the entire sample. No significant interaction between SRM and Group was found, while a significant interaction between SWM strategy and Group emerged; in patients the magnitude of this association was approximately twofold larger than in HCs. OC symptom severity did not correlate with neuropsychological performance. Conclusions: Patients with OCD had poorer spatial store capacity than HCs. However, the weight of poorer executive strategy in SWM was greater in patients than HCs, whereas the weight of spatial store was similar. We provided a direct evidence that an impairment in the executive component might be the crucial factor influencing the poorer SWM of these patients.
A controlled trial of HNSCC patient‐derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth

Head and neck squamous cell carcinomas (HNSCCs) frequently harbor alterations in the PI3K/AKT/mTOR signaling axis, particularly in the PIK3CA gene. PI3K‐targeted agents have therefore gained considerable preclinical and clinical interest as emerging therapies for HNSCC. Identification of predictive biomarkers of response would advance the clinical application of PI3K‐targeted drugs for patients, in order to achieve maximal benefit. To date, studies of drug biomarkers have largely focused on screening cell lines, with much more limited in vivo testing, usually only as validation. This approach has rarely enabled accurate predictions of clinical efficacy. Recently, clinical trials of PDX models (PDX clinical trials) have been introduced as a preclinical approach to interrogate interpatient response heterogeneity. Already, PDX clinical trial responses have been demonstrated to correlate closely with patient outcomes. Here, using both an HNSCC specific, 28‐cell line panel and a PDX clinical trial of 80 xenografts derived from 20 unique HNSCC tumors, we systematically examine patterns of response to PI3K inhibition in HNSCC. We find EGFR, AKT1 and CSMD1 copy number aberrations, but not PIK3CA mutations, to be associated with responsiveness to PI3K‐targeted drugs. Further, we reveal PI3Kα inhibition to be almost globally tumoristatic in HNSCC xenografts regardless of PIK3CA mutational status, emphasizing its potential as a stabilizing neoadjuvant therapy for HNSCC patients.
Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk Profile

Background: Dietary total antioxidant capacity (TAC), glycemic index (GI), and glycemic load (GL) are accepted indicators of diet quality, which have an effect on diet–disease relationships. The aim of this study was to evaluate potential associations of dietary TAC, GI, and GL with variables related to nutritive status and insulin resistance (IR) risk in cardiometabolic subjects. Methods: A total of 112 overweight or obese adults (age: 50.8 ± 9 years old) were included in the trial. Dietary intake was assessed by a validated 137-item food frequency questionnaire (FFQ), which was also used to calculate the dietary TAC, GI, and GL. Anthropometrics, blood pressure, body composition by dual-energy X-ray absorptiometry (DXA), glycemic and lipid profiles, C-reactive protein (CRP), as well as fatty liver quantification by magnetic resonance imaging (MRI) were assessed. Results: Subjects with higher values of TAC had significantly lower circulating insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR). Participants with higher values of HOMA-IR showed significantly higher GI and GL. Correlation analyses showed relevant inverse associations of GI and GL with TAC. A regression model evidenced a relationship of HOMA-IR with TAC, GI, and GL. Conclusion: This data reinforces the concept that dietary TAC, GI, and GL are potential markers of diet quality, which have an impact on the susceptible population with a cardiometabolic risk profile.
Profil épidémiologique et anatomopathologique du cancer colorectal: à propos de 36 caswe

Le cancer colorectal est classé parmi les cancers les plus fréquents au monde (3ème rang après le cancer du sein et celui de la prostate), deuxième cancer digestif au Maroc après celui de l'estomac. Cependant son incidence dans notre pays reste moins élevée que celle des pays occidentaux (2.5 à 3.3/100 000 ha) mais rejoint celle des pays du Maghreb dont ce cancer touche les sujets jeunes dans 27% des cas. Le cancer colorectal (CCR) est un des meilleurs exemples du processus multi étape de cancérogenèse. La connaissance des caractéristiques anatomopathologique du CCR conditionnera certainement nos attitudes thérapeutiques. Nous avons mené une étude rétrospective épidémiologique et anatomopathologique au service de chirurgie viscérale de l'hôpital militaire Moulay Ismail à Meknès sur une période de 5 ans allant du mois de janvier 2012 au mois de Décembre 2016 (36 cas: 14 femmes et 22 hommes). À la lumière de cette étude, l'objectif de ce travail est d'analyser le profil épidémiologique et les aspects anatomopathologiques des cancers colorectaux. L'analyse de nos résultats montre un profil épidémiologique particulier qui se caractérise par un âge plus jeune, une répartition selon le sexe en faveur des hommes, les carcinomes sporadiques sont largement prédominants avec une répartition topographique recto sigmoïdienne fréquemment observée. Sur le plan pronostique, le faible degré de différenciation des adénocarcinomes et le type mucineux sont corrélés à un stade TNM et d'Aster Coller avancés, avec un statut ganglionnaire péjoratif. Cette approche multidisciplinaire sera une première nationale, rendant ainsi notre structure de pratique et de recherche médicale l'une des plateformes de prise en charge multidisciplinaire du cancer colorectal au Maroc.
Lymph node imaging of pediatric renal and suprarenal malignancies

Pediatric renal and suprarenal cancers are relatively rare malignancies, but are not without significant consequence to both the patient and caretakers. These tumors are often found incidentally and present as large abdominal masses. Standard of care management involves surgical excision of the mass, but contemporary treatment guidelines advocate for use of neoadjuvant or adjuvant chemotherapy for advanced stage disease, such as those cases with lymph node involvement (LNI). However, LNI detection is based primarily on surgical pathology and performing extended lymph node dissection can add significant morbidity to a surgical case. In this review, we focus on the use and performance of imaging modalities to detect LNI in Wilms’ tumor (WT), neuroblastoma, and pediatric renal cell carcinoma (RCC). We report on how imaging impacts management of these cases and the clinical implications of LNI. A literature search was conducted for studies published on imaging-based detection of LNI in pediatric renal and suprarenal cancers. Further review focused on surgical and medical management of those cases with suspected LNI. Current imaging protocols assisting in diagnosis and staging of pediatric renal and suprarenal cancers are generally limited to abdominal ultrasound and cross-sectional imaging, mainly computed tomography (CT). Recent research has investigated the role of more advance modalities, such as magnetic resonance imaging (MRI) and positron emission tomography (PET), in the management of these malignancies. Special consideration must be made for pediatric patients who are more vulnerable to ionizing radiation and have characteristic imaging features different from adult controls. Management of pediatric renal and suprarenal cancers is influenced by LNI, but the rarity of these conditions has limited the volume of clinical research regarding imaging-based staging. As such, standardized criteria for LNI on imaging are lacking. Nevertheless, advanced imaging modalities are being investigated and potentially represent more accurate and safer options.
Short-Term Modifications of Postural Balance Control in Young Healthy Subjects After Moderate Aquatic and Land Treadmill Running

Postural balance control can be altered by land treadmill (LTM) running. This impairment seems to be related to a disturbance of vestibular and visual information. However, no studies are available on aquatic treadmill (ATM) running. The aim of the present study was to investigate the effect of running at moderate intensity over ATM and LTM on the postural balance control both with opened (OE) and closed (CE) eyes. Center of pressure (CoP) trajectory of 20 healthy subjects was collected on a dynamometric platform before and after a 20-min-long running on ATM and LTM at the same rate of perceived exertion (Borg's scale: 3/10). Heart rate (HR) was recorded every 30 s during running. Stabilogram diffusion analysis (SDA) and sample entropy (SampEn) were calculated to deepen motor control mechanisms. HR values were lower during ATM running with respect to LTM running (p < 0.01). A significant effect of the treadmill factor was detected in the OE condition for the sway path (p < 0.01; ηp2 = 0.364; Power: 0.879), the sway area (p < 0.01; ηp2 = 0.324; Power: 0.816), and the ML oscillations (p < 0.01; ηp2 = 0.390; Power: 0.911) while an effect of the time factor was detected for the ellipse area (p < 0.05; ηp2 = 0.213; Power: 0.576). However, the effect size for all the parameters ranged from 0.06 (trivial) to 0.48 (small). In the OE condition, the SDA highlighted a significant effect of the treadmill factor on all the short-term diffusion coefficients which negatively influenced the open loop motor control strategies. In the CE condition, SampEn analysis underlined a significant decrease of the CoP regularity after LTM running. Although slight modifications of the mechanisms involved in the postural balance control occurred, ATM and LTM moderate running did not seriously threaten postural balance performance. Therefore, the usage of ATM should be taken into account in all those situations where the well-known advantages of the aquatic environment are priorities.