Miracle-dz/UniFAR-FTUs huggingface dataset:
Cortical reactions to verbal abuse: event-related brain potentials reflecting the processing of socially threatening words

Human information processing is sensitive to aversive stimuli, in particular to negative cues that indicate a threat to physical integrity. We investigated the extent to which these findings can be transferred to stimuli that are associated with a social rather than a physical threat. Event-related potentials were recorded during silent reading of neutral, positive, physically threatening, and socially threatening words, whereby socially threatening words were represented by swear words. We found facilitated processing of positive and physically threatening words in contrast to both neutral and socially threatening words at a first potential that emerged at about 120 ms after stimulus onset. At a semantic processing stage reflected by the N400, processing of all classes of affective words, including socially threatening words, differed from neutral words. We conclude that socially threatening words as well as neutral words capture more attentional resources than positive and physically threatening words at early stages. However, social threatening words are processed in a manner similar to other emotional words and different from neutral words at higher levels.
Type I CD36 deficiency in hematologic disorder.

We report a 64 year old man with type I CD36 deficiency. He diagnosed as having diffuse large B cell nonHodgkin’s lymphoma (NHL) and treated with chemotherapy and radiation. He had no history of previous blood transfusions. His electrocardiogram (ECG) and echocardiogram were almost normal. However, I-βmethyl-iodophenyl pentadecanoic acid (BMIPP) cardiac scintigraphy showed complete absence of BMIPP accumulation in the heart (Figure 1). Flow cytometry analysis revealed absence of CD36 on the monocytes and platelets (Figure 2), suggesting the diagnosis of type I CD36 deficiency, as well as NHL. In patients with type I CD36 deficiency, immunization with CD36 antigen by transfusion, could produce anti-CD36 antibody, and potentially lead to platelet transfusion refractoriness or posttansfusion purpura. When transfusion lead to platelet transfusion refractoriness or posttansfusion purpura, we must take Type I CD36 deficiency into consideration.
Definability and decidability issues in extensions of the integers with the divisibility predicate

Abstract Let be a first-order structure; we denote by DEF() the set of all first-order definable relations and functions within . Let π be any one-to-one function from ℕ into the set of prime integers. Let ∣ and • be respectively the divisibility relation and multiplication as function. We show that the sets DEF(ℕ, π, ∣) and DEF(ℕ, π, •) are equal. However there exists function π such that the set DEF(ℕ, +, ∣), or, equivalently, DEF(ℕ, π, •) is not equal to DEF(ℕ, +, •). Nevertheless, in all cases there is an {π, •}-definable and hence also {π, |}-definable structure over π which is isomorphic to 〈ℕ, +, •〉. Hence theories TH(ℕ, π, ∣) and TH(ℕ, π, •) are undecidable. The binary relation of equipotence between two positive integers saying that they have equal number of prime divisors is not definable within the divisibility lattice over positive integers. We prove it first by comparing the lower bound of the computational complexity of the additive theory of positive integers and of the upper bound of the computational complexity of the theory of the mentioned lattice. The last section provides a self-contained alternative proof of this latter result based on a decision method linked to an elimination of quantifiers via specific tables.
Effects of brefeldin a on the three‐dimensional structure of the golgi apparatus in a sensitive strain of saccharomyces cerevisiae

Background: Brefeldin A (BFA), when added to the medium of cultured mammalian cells, induces a reversible block of secretion and disrupts the Golgi apparatus whereas Golgi enzyme markers appear to redistribute into the endoplasmic reticulum (ER). It has been shown in addition that in mammalian cells, BFA would prevent the assembly of coatomer proteins (COP) onto membranes by inhibiting the GTP‐dependent interaction of the ADP‐ribosylation factor (ARF) with such membranes. The purpose of the present study is to analyze, by stereoelectron microscopy, the structural modifications of Golgi elements and of the ER‐Golgi relationship in a BFA‐sensitive yeast mutant, S. cerevisiae erg6.
Novel design of UHF RFID near-field antenna for smart shelf applications

This paper presents the design of UHF RFID read/write (R/W) antenna to be used in a variety of smart shelf retail applications. The design principle based on the EM coupling between open-ended MS feed line and periodic planar metal strips is presented. The proposed antenna can be easily customized for the required aria of smart shelf RFID interrogation. Several antenna prototypes have been designed, produced and measured. The antenna performance has been evaluated in UHF RFID system for the simultaneous detection of arbitrary oriented tagged apparel items placed on the antenna surface. The proposed antenna demonstrates excellent ability to provide strong and uniform E-field distribution at the distances up to 50 cm form the antenna surface.
Slow inward tail currents in rabbit cardiac cells.

1. A whole‐cell gigaseal suction microelectrode voltage‐clamp technique has been used to study slow inward tail currents in single myocytes obtained by enzymatic dispersion of rabbit ventricle and atrium. A variety of stimulation protocols, Tyrode solutions and pharmacological agents have been used to test three hypotheses: (a) that the slow inward tail current is generated by an electrogenic Na(+)‐Ca2+ exchanger; (b) that a rise in [Ca2+]i, due to release from the sarcoplasmic reticulum can modulate the activity of this exchanger; and (c) that the uptake of calcium by the sarcoplasmic reticulum is a major determinant of the time course of the tail current. 2. As shown previously in amphibian atrium and guinea‐pig ventricle, slow inward tail currents can be observed consistently under conditions in which action potentials and ionic currents are recorded using microelectrode constituents which only minimally disturb the intracellular milieu. 3. In ventricular cells, the envelope of these tail currents obtained by varying the duration of the preceding depolarizations shows that (a) the tail currents are activated by pulses as short as 10 ms, and reach a maximum for pulse durations of 100‐200 ms, (b) the rate of decay of the tail current gradually increases as the activating depolarizations are prolonged, and (c) the tails cannot be due to deactivation of calcium currents, in agreement with other studies in frog heart. 4. When the mean level of [Ca2+]i is raised following inhibition of the Na(+)‐K+ pump by strophanthidin (10(‐5) M) or reductions in [K+]o (0.5 mM), the slow inward tail grows in size prior to the onset of a contracture or other signs of calcium‐induced toxicity. 5. In a number of different preparations, replacement of [Ca2+]o with BaCl2 markedly or completely inhibits the Na(+)‐Ca2+ exchanger, whereas Sr2+ replacement does not have this effect. In myocytes from rabbit ventricle the slow inward tails are reduced significantly and decay more slowly in 0.5‐2.2 mM‐BaCl2 Tyrode solution, while in 2.2 mM SrCl2 these tails are not altered. 6. The slow inward tail also shows a dependence on [K+]o, corresponding to previous data on Na(+)‐Ca2+ exchange in other tissues. Increasing [K+]o in the Tyrode solution to a final concentration of 10‐15 mM results in a marked inhibition of the slow tails. This effect cannot be accounted for by changes in the inwardly rectifying potassium current, IK1. 7. The slow tail currents were changed significantly by increasing the temperature of the superfusing Tyrode solution. (ABSTRACT TRUNCATED AT 400 WORDS)
High step-up DC-DC converter with coupled inductor and reduced switch-voltage stress

This paper investigates a high step-up dc-dc buck-boost converter with reduced switch-voltage stress. The traditional dcdc buck-boost converter can not provide the very high voltage gain function by itself. By replacing the inductor of a classical buck-boost converter with a cell formed by a coupled inductor and one diode, a new converter with high voltage ratio is obtained. The energy accumulated in the leakage inductance is transferred to the load in a non-oscillatory manner. The essential problem of this circuit is a very high voltage stresses on the transistor and on the diodes. The splitting of the secondary inductor into two windings significantly reduces these voltage stresses. The DC gain and maximal voltage stresses expressions are obtained. Simulation and experimental results confirm the theoretical analysis and the advantages of the proposed converters.
A CORRELATIVE STUDY OF THE HISTOCHEMICAL PROPERTIES OF RODENT ACID MUCOPOLYSACCHARIDES

The staining properties of several rodent mucopolysaccharides with alcian blue and with azure A at controlled pH have been surveyed and compared with available radioautographic data of S35O4 incorporation in mucins. The effects of treatment with acid methanol and of sulfation on the staining have been determined. One sulfated, metachromatic and strongly acid type of mucin stains weakly if at all with alcian blue, remaining unstained by alcian blue in the combined alcian blue periodic acid Schiff or alcian blue-azure A (or safranin) procedures, but loses azurophilia while gaining alcian blue reactivity after mild (4 hr 37°) treatment with acid methanol. Some (probably) sulfated mucins stain fully with both dyes and others, presumably also sulfated, color only partially with azure A at pH 1.5, but maximally with alcian blue. The latter two types of substances partially or completely resist supression of either staining reaction by the "mild methylation". A fourth category stains meta- or orthochromatically at pH 2.5 to 3, or not at all, with azure A, and colors strongly with alcian blue. Some of the latter mucins are sulfated and remain unaltered after mild treatment with acid methanol, whereas others appear to be nonsulfated and lose basophilia reversibly with such treatment. It is suggested that alcian blue staining and metachromasia or orthochromasia with azure A above pH 2.5 which is blocked after 4 hours in acid methanol at 37°C and restored by brief saponification, may be attributed to nonsulfated mucopolysaccharides containing strongly acidic carboxyls. A four hour acidic methylation at 69° eliminates nearly all the basophilia of acid mucins, and saponification restores alcian blue staining to some, but not azurophilia below pH 3.0. Sulfation of histologic sections renders many neutral and all acid mucins fully chromotropic toward azure A at pH 1.5, but obstructs their alcian blue staining. Exposure to acid methanol after sulfation restores reactivity toward alcian blue and eliminates most artificial azurophilia; but the neutral mucins in Brunner's glands and mucous neck cells of rats and mice remain metachromatic and develop alcian blue affinity. Strong treatment with acid methanol increases the periodic acid Schiff staining of several subfated mucopolysaccharides of the rabbit. Staining with azure A or safranin after alcian blue differentiates alcian blue-negative and -positive sulfated polysaccharides. Failure of sulfate-free acid mucins to stain with alcian blue above the pH of their dissociation and resistance of the dye complex with these mucins to dissolution by acid or alkali is interpreted as evidence against the alcian blue-substrate complex involving a salt linkage.
Molecularly targeted therapy for malignant glioma

Malignant gliomas are relatively uncommon but lethal cancers. Despite recent research efforts in cancer therapy, the prognosis of patients with malignant gliomas has remained dismal. Understanding the molecular pathogenesis of glioma may lead to a rational development of new therapies. Despite the genetic heterogeneity of malignant gliomas, common aberrations in the signaling elements of the growth and survival pathways are found. New treatments have emerged to target molecules in these signaling pathways with the goal to increase specific efficacy and minimize toxicity. Monoclonal antibodies and low molecular‐weight kinase inhibitors are the most common classes of agents in targeted cancer treatment. Most clinical trials of these agents as monotherapies have failed to demonstrate survival benefit in unselected malignant glioma patient populations. Several mechanisms of treatment failure have been demonstrated. In response, multitargeted kinase inhibitors and combinations of single‐targeted kinase inhibitors have been developed to overcome therapeutic resistance. In addition, multimodality combinations of targeted agents with radiation, chemotherapy, or immunotherapy/vaccines may enhance treatment efficacy. Future development of these agents will require advances in discovery and validation of new molecular targets, improvement of therapeutic delivery, and identification of correlative biomarkers. Novel clinical trial designs and endpoints may increase the efficiency of new drug evaluation. In this review, the authors discussed the current understanding of molecular pathogenesis and the development of molecularly targeted therapies in malignant glioma. Cancer 2007. © 2007 American Cancer Society.
Chordoma and malignant fibrous histiocytoma.Evidence for transformation

Serial biopsy specimens of a histologically proven cervical chordoma in a 57‐year‐old woman taken at intervals over a 7‐year period, demonstrate a progression and complete transformation to a malignant fibrous histiocytoma 5 years following radiation therapy. Intermediate spindle‐shaped cells demonstrating keratin positivity were discovered, lending credence to the theory of cellular transformation. Additionally, a fine reticulin network was noted around the chordoma cells. A review of the literature is undertaken chronicling the documented associations of chordoma and sarcoma, followed by a discussion of the various causes proposed to explain this phenomenon. Cancer 58:1082‐1087, 1986.
Preparation and evaluation of chitosan beads immobilized with Iron(III) for the removal of As(III) and As(V) from water

The crosslinked chitosan-Fe(III) (Ch-FeCL) adsorbent was developed using Fe(III) immobilized on chitosan beads. After drying, the beads presented a diameter of approximately 1 mm and are stable in air. The adsorption behavior of As(III) and As(V) on the Ch-FeCL was evaluated at pH 7 by studies conducted in batch and in columns. Maximum adsorption capacities estimated by the Langmuir adsorption model were 21.24 and 27.59 mg g-1 for As(III) and As(V), respectively. Adsorption kinetics is described by the pseudo second order kinetic equation. The results of column adsorption indicated that arsenic was not found in the effluent solution from roughly 60 and 759 bed volumes for As(III) and As(V), respectively. Results were satisfactory when employing the adsorbent for removal of As(III) and As(V) from groundwater, tap water and river water samples.
A Novel Intelligent Recommendation Algorithm based on Web Data Mining Technique under the Background of Deep Neural Network

The development of the Internet brought us into an era of big data information, give people bring convenient while and also make people ragged when choosing the required information and recommendation system arises at the historic moment, and get the wide attention and applications. Therefore, to enhance the traditional method, we propose a novel intelligent recommendation algorithm based on Web data mining technique under the background of the deep neural network. Firstly, we review the state-of-the-art web data mining algorithms and revise the traditional ones with the parallel data mining algorithm on the multiple processors to perform tasks that will enhance the accuracy and efficiency. Then, we analyze basic neural network model through the inner connection and weight transfer. Later, we introduce the deep network structure to enhance the traditional network. Finally, we combine the revised prior theories into the recommending tasks for enhancement. The experimental analysis show that our algorithm accuracy is enhanced by the extent of 56% and overall time is reduced to the 87% of traditional ones which proves the feasibility. Later, more optimization work will be introduced to modify the current methodology.
Distinctive distribution of HPV genotypes in cervical cancers in multi-ethnic Suriname: implications for prevention and vaccination

SUMMARY Suriname is ranked as high-risk country for cervical cancer, but recent national data of HPV prevalence and distribution in cervical cancer is scarce. In a retrospective cross-sectional study, cervical cancer incidence, HPV prevalence and HPV-type-specific distribution were investigated in all cervical cancer cases (n = 111), diagnosed in two consecutive years. HPV presence and type-specific prevalence were determined in paraffin-embedded biopsies utilizing master-nested multiplex PCR assays, targeting 14 HPV types. The age-standardized incidence rate of cervical cancer was 22·4/100 000 women, justifying revision of the current international ranking of Suriname. Eleven HPV types were detected, with the most common types in descending order of frequency: 16, 18, 45, 66, 58/52/35. HPV16 was predominant, although with markedly low presence (25%). HPV16 or 18 infections were detected in 43% of the cases, while 28% were untyped, implicating a divergent HPV-type distribution in Suriname with significant variation in the prevalence of less common high-risk virus types and/or presence of HPV16 variants. HPV-type distribution differed between ethnic groups. A vaccination efficacy of just 28–30% was anticipated, next to an uneven vaccination impact in different ethnic groups, cautioning Suriname and other multi-ethnic countries to tailor the information presented to different ethnic communities.
Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging

We tested the hypothesis that short‐term nitrite therapy reverses vascular endothelial dysfunction and large elastic artery stiffening with aging, and reduces arterial oxidative stress and inflammation. Nitrite concentrations were lower (P < 0.05) in arteries, heart, and plasma of old (26–28 month) male C57BL6 control mice, and 3 weeks of sodium nitrite (50 mg L−1 in drinking water) restored nitrite levels to or above young (4–6 month) controls. Isolated carotid arteries of old control mice had lower acetylcholine (ACh)‐induced endothelium‐dependent dilation (EDD) (71.7 ± 6.1% vs. 93.0 ± 2.0%) mediated by reduced nitric oxide (NO) bioavailability (P < 0.05 vs. young), and sodium nitrite restored EDD (95.5 ± 1.6%) by increasing NO bioavailability. 4‐Hydroxy‐2,2,6,6‐tetramethylpiperidine 1‐oxyl (TEMPOL), a superoxide dismutase (SOD) mimetic, apocynin, a nicotinamide adenine dinucleotide phosphate‐oxidase (NADPH) inhibitor, and sepiapterin (exogenous tetrahydrobiopterin) each restored EDD to ACh in old control, but had no effect in old nitrite‐supplemented mice. Old control mice had increased aortic pulse wave velocity (478 ± 16 vs. 332 ± 12 AU, P < 0.05 vs. young), which nitrite supplementation lowered (384 ± 27 AU). Nitrotyrosine, superoxide production, and expression of NADPH oxidase were ∼100–300% greater and SOD activity was ∼50% lower in old control mice (all P < 0.05 vs. young), but were ameliorated by sodium nitrite treatment. Inflammatory cytokines were markedly increased in old control mice (P < 0.05), but reduced to levels of young controls with nitrite supplementation. Short‐term nitrite therapy reverses age‐associated vascular endothelial dysfunction, large elastic artery stiffness, oxidative stress, and inflammation. Sodium nitrite may be a novel therapy for treating arterial aging in humans.
Smart grid cyber security requirements

The transformation of the traditional power grid into a network of intelligent energy distribution able to meet the growing needs of efficiency and environmental impact involves, not only a historical and technical development, but also a profound transformation of the entire existing infrastructure. Given the undeniable benefits introduced, the new smart energy network vulnerabilities are found both in the communication system and power distribution. This paper aims to explore requirements for the smart grid security issues.
Factors Affecting the Spread and Duration of Epidural Anesthesia with Ropivacaine

Background:Epidural anesthesia has an unpredictable extent and duration. Differences in the surface area of the lumbosacral dura, epidural fat volume, and epidural venous plexus velocity might explain the variability in the extent and duration of epidural anesthesia with ropivacaine. Methods:Twenty-six healthy patients, aged 18–45 y, undergoing peripheral orthopedic surgery were enrolled. Dural surface area and posterior epidural fat volume were calculated from low thoracic, lumbar, and sacral axial magnetic resonance images obtained at 8-mm increments. Epidural venous plexus velocity at the L3–L4 disk level was derived from phase-contrast magnetic resonance images. The patients received 100 mg ropivacaine (1.0%) epidurally. The spread and duration of sensory anesthesia was assessed by pinprick, and that of motor block was assessed using a modified Bromage scale. Statistical correlation coefficients (&rgr;) between magnetic resonance imaging and epidural anesthesia measurements were assessed by Spearman rank correlation. Stepwise multiple linear regression models were used to select important predictors of measures of epidural anesthesia. Results:Dural surface area correlated with peak sensory block level (&rgr; = −0.73, P = 0.0003) and onset time of caudal and cephalad block (&rgr; = 0.62, P = 0.002; &rgr; = −0.63, P = 0.002). Fat volume correlated with the regression to L5–S3 (&rgr; = −0.44 to −0.54, P = 0.029 to 0.007). Epidural venous plexus velocity was significantly correlated with the regression to L3 (&rgr; = −0.42, P = 0.038) and L4 (&rgr; = −0.48, P = 0.017). Multiple regression analysis revealed that dural surface area was a significant predictive variable for the peak sensory block level (R2 = 0.61, P < 0.0001). Conclusions:These findings indicate that dural surface area influences the spread of epidural anesthesia with ropivacaine and posterior fat volume influences the duration of epidural anesthesia in healthy patients within a narrow age range. Epidural venous plexus velocity might also influence the duration of epidural anesthesia with ropivacaine.