Miracle-dz/UniFAR-FTUs huggingface dataset:
Moisturizing effect of cream containing Moringa oleifera (Sohajana) leaf extract by biophysical techniques: In vivo evaluation

The purpose of this present investigation is to evaluate the moisturizing effects of cosmetic creams containing extract of Moringa oleifera leaves (Sohajana) by non-invasive bioengineering techniques. The study was conducted during the winter months (October to January). A total of eleven healthy male volunteers with ages between 20 and 35 years contributed to accomplish this single blind study. The active cream and base were applied twice daily to the face (cheeks) for a period of 12 weeks. The instrumental measurements were carried out with tewameter and corneometer under a draught-free room, with controlled temperature (18.0 to 20.6°C) and relative humidity (55 to 65%). The results recommended that the assessed outcome was very well accepted, and improved skin hydration and skin barrier function by the test product. There was a significant decrease in skin transepidermal water loss (TEWL) and increase in skin hydration achieved when ANOVA and paired t-sample test were applied. Key words: Moringa oleifera, extract, cream, corneometer, tewameter, moisturizer
The CT flare response of metastatic bone disease in prostate cancer

Background New or worsening bone lesions in patients responding to treatment, known as the flare phenomenon is well described on 99mTc-MDP bone scintigraphy, but to our knowledge has not previously been described on CT. The appearance of new or worsening bone sclerosis on CT in patients with prostate cancer may therefore be erroneously classified as disease progression. Purpose To assess the incidence of osteoblastic healing flare response at 3-month CT assessment in patients with castrate-resistant prostate cancer and to identify associated features that enable differentiation from progressive metastatic bone disease at 3 months. Material and Methods CT scans of 67 patients with castrate-resistant prostate cancer undergoing treatment were reviewed by a radiologist blinded to clinical outcome. Changes in number, size, and density of metastatic bone lesions were documented and Response Evaluation Criteria in Solid Tumours (RECIST) in soft tissue lesions, alkaline phosphatase, prostate specific antigen, and 99mTc-MDP bone scans were used for correlation. Results Of the 39 patients who had 3- and 6-month follow-up, eight patients (21%) demonstrated an increase in number, size, or density of sclerotic lesions on the 3-month CT scan despite improvement in PSA and soft tissue lesions. Three out of eight patients (8%) maintained partial response/remained stable at follow-up and were defined as showing a flare response: in this group bone metastases evident on CT showed a qualitative and quantitative increase in density and no lesions faded at 3 months. In contrast, in all patients who progressed at 3 months by PSA/RECIST criteria (n = 8) bone lesions showed a mixed pattern with some lesions increasing and others decreasing in density. Conclusion The incidence of flare response of metastatic bone disease evident at 3-month post-treatment CT in patients with prostate cancer undergoing systemic treatment is 8%. In patients with falling PSA and stable/responding soft tissue disease at 3 months an increase in bone sclerosis in the absence of fading bone metastases can be interpreted as flare and is likely to represent a response.
Recent thermal management techniques for microprocessors

Microprocessor design has recently encountered many constraints such as power, energy, reliability, and temperature. Among these challenging issues, temperature-related issues have become especially important within the past several years. We summarize recent thermal management techniques for microprocessors, focusing on those that affect or rely on the microarchitecture. We categorize thermal management techniques into six main categories: temperature monitoring, microarchitectural techniques, floorplanning, OS/compiler techniques, liquid cooling techniques, and thermal reliability/security. Temperature monitoring, a requirement for Dynamic Thermal Management (DTM), includes temperature estimation and sensor placement techniques for accurate temperature measurement or estimation. Microarchitectural techniques include both static and dynamic thermal management techniques that control hardware structures. Floorplanning covers a range of thermal-aware floorplanning techniques for 2D and 3D microprocessors. OS/compiler techniques include thermal-aware task scheduling and instruction scheduling techniques. Liquid cooling techniques are higher-capacity alternatives to conventional air cooling techniques. Thermal reliability/security issues cover temperature-dependent reliability modeling, Dynamic Reliability Management (DRM), and malicious codes that specifically cause overheating. Temperature-related issues will only become more challenging as process technology continues to evolve and transistor densities scale up faster than power per transistor scales down. The overall objective of this survey is to give microprocessor designers a broad perspective on various aspects of designing thermal-aware microprocessors and to guide future thermal management studies.
Obesidade em adolescentes e as políticas públicas de nutrição

In recent years, obesity has become a major public health problem and its prevalence is increasing at an alarming pace. Moreover, this problem has affected children and adolescents in marked fashion. Considering this situation, public policies on nutrition were created as strategies to attempt to combat/control the high Brazilian obesity indices. The scope of this study was to conduct a historical analysis of the advances in Brazilian public policies related to nutrition/food and the practice of physical exercise to control obesity among adolescents. In this respect, a review was conducted of the literature in the PubMed and SciELO electronic databases that addresses Brazilian public policies on nutrition in the control of obesity. Official documents of the Ministry of Health, scientific articles, journals and the recommendations of the World Health Organization were also used in the research. The results revealed that public policies on nutrition practiced in Brazil have been implemented in an incipient manner when directed at adolescents with respect to the obesity factor. Therefore, a broader vision seeking policies that attempt to control obesity in adolescents is of paramount importance.
Confinement Facilitated Protein Stabilization As Investigated by Small-Angle Neutron Scattering

While mesoporous silicas have been shown to be a compelling candidate for drug delivery and the implementation of biotechnological applications requiring protein confinement and immobilization, the understanding of protein behavior upon physical adsorption into silica pores is limited. Many indirect methods are available to assess general adsorbed protein stability, such as Fourier-transform infrared spectroscopy and activity assays. However, the limitation of these methods is that spatial protein arrangement within the pores cannot be assessed. Mesoporous silicas pose a distinct challenge to direct methods, such as transmission electron microscopy, which lacks the contrast and resolution required to adequately observe immobilized protein structure, and nuclear magnetic resonance, which is computationally intensive and requires knowledge of the primary structure a priori. Small-angle neutron scattering can surmount these limitations and observe spatial protein arrangement within pores. Hereby, we observe the stabilization of fluid-like protein arrangement, facilitated by geometry-dependent crowding effects in cylindrical pores of ordered mesoporous silica, SBA-15. Stabilization is induced from a fluid-like structure factor, which is observed for samples at maximum protein loading in SBA-15 with pore diameters of 6.4 and 8.1 nm. Application of this effect for prevention of irreversible aggregation in high concentration environments is proposed.
iRotate: automatic screen rotation based on face orientation

We present iRotate, an approach to automatically rotate screens on mobile devices to match users' face orientation. Current approaches to automatic screen rotation are based on gravity and device orientation. Our survey of 513 users shows that 42% currently experience auto-rotation that leads to incorrect viewing orientation several times a week or more, and 24% find the problem to be very serious to extremely serious. iRotate augments gravity-based approach, and uses front cameras on mobile devices to detect users' faces and rotates screens accordingly. It requires no explicit user input and supports different user postures and device orientations. We have implemented a iRotate that works in real-time on iPhone and iPad, and we assess the accuracy and limitations of iRotate through a 20- participant feasibility study.
Fetal cardiac output and its distribution to the placenta and brain at 11-20 weeks of gestation

The three papers of the thesis are not available in Munin due to publisher's restrictions: 1. Vimpeli T, Huhtala H and Acharya G. 'Fetal echocardiography during routine first-trimester screening: a feasibility study in an unselected population' Prenatal Diagnosis 2006;26(5):475-482 (Wiley). Available at http://dx.doi. org/10.1002/pd.1442 2. Vimpeli T, Huhtala H, Wilsgaard T and Acharya G. 'Fetal cardiac output and its distribution to the placenta at 11-20 weeks of gestation' Ultrasound in Obstetrics and Gynecology 2009;33(3):265 - 271 (Wiley) http://dx.doi. org/10.1002/uog.6247 3. Vimpeli T, Huhtala H, Wilsgaard T and Acharya G. 'Fetal aortic isthmus blood flow and the fraction of cardiac output distributed to the upper body and brain at 11-20 weeks of gestation' Ultrasound in Obstetrics and Gynecology 2009;33(5):538-44 (Wiley) http://dx.doi. org/10.1002/uog.6354
The Importance of Some Possible Somatic and Environmental Risk Factors for the Development of Migraine

Background: The study of risk factors of migraine is important, not least because migraine prevalence seems to increase. The knowledge of risk factors remains limited, however, despite years of research. The objective was to evaluate some possible somatic and environmental risk factors for the development of migraine. Methods: The Danish Twin Omnibus 1994 and 2002 were questionnaire surveys investigating somatic disorders, lifestyle factors and socioeconomic factors. Both studies used the same validated questions to diagnose migraine. The study population included twin individuals born between 1953 and 1976 who in 1994 reported never to have had migraine. We compared the groups with and without a specific disorder or environmental factor in 1994 with regard to their migraine status in 2002. Results: This study comprised 13,498 subjects (6,513 men and 6,985 women). The 8-year risk of developing migraine was significantly increased in subjects who already had low back pain (odds ratio (OR) = 1.3; 95% CI = 1.2 - 1.4). Environmental factors associated with an increased risk of development of migraine were low education (OR = 1.3; 95% CI = 1.1 - 1.5), heavy physical workload (OR = 1.1; 95% CI = 1.0 - 1.2), heavy physical recreational activity (OR = 1.2; 95% CI = 1.0 - 1.3) and body mass index (BMI) < 18.5 (OR = 1.3; 95% CI = 1.1 - 1.6). Subjects with weekly or more frequent alcohol consumption had a lower risk of developing migraine compared to subjects with less frequent or no consumption of alcohol (OR = 0.6; 95% CI = 0.6 - 0.7). Conclusions: This large-scale longitudinal population-based study showed that the risk of development of self-reported migraine was increased in subjects with low back pain, low education, heavy physical workload and heavy physical recreational activity, and decreased in those with frequent alcohol consumption. J Neurol Res. 2015;5(3):193-198 doi: http://dx.doi. org/10.14740/jnr336w
Anxiety and substance use: layers of complexity

Anxiety and substance use disorders occur together much more commonly than would be expected by chance, as shown in both general population and clinical samples. The clinical importance of this is that the outcome for each type of disorder is worse across clinical and psychosocial domains than for the disorders that occur noncomorbidly. This review explores explanatory models for comorbidity, outlines assessment protocols that can be employed in both screening and in treatment planning, as well as assessing the efficacy of applied interventions. Treatment options are presented, and the evidence base for various psychosocial and biological treatments are reviewed.
Targeting TRPM8 for Pain Relief

Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by cold temperature and cooling agents. TRPM8 is expressed in peripheral cold thermoreceptors and plays a fundamental role in sensing mild, cool temperatures. In addition, cumulative evidence obtained in humans and different animals models, combined with pharmacological and gene silencing techniques, suggest that TRPM8 may also play a role in cold discomfort and the pathophysiology of cold pain. This article reviews the available evidence in a critical fashion. In addition, the article reviews the possible role of TRPM8 in basal tearing, cold urticaria and airway irritation. Collectively, these results suggest that pharmacological modulators of TRPM8 could have potential indications in a variety of conditions, including dry eye disease, airway irritation, teeth hypersensitivity, migraine and neuropathic pain. However, additional studies, especially in humans, are needed to verify these preliminary observations. The paucity of potent, specific pharmacological TRPM8 antagonists available is a current limitation for further progress in this field.
Associations between sedentary behaviour and cardiovascular, haemostatic and diabetic markers in mid-adult life (45 years)

Background Recent studies show TV-viewing time being related to mortality independent to physical activity (PA). However, the mechanism behind this association is unclear. Aim We investigate cross-sectional associations between sedentary behaviour and preclinical variations in markers for cardiovascular disease (CVD) and diabetes. Methods Using data from the 1958 British birth cohort, we analysed associations between (1) television (TV)-viewing and (2) sitting at work with blood pressure (BP), total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), glycated haemoglobin (HbA1c), C-reactive protein (CRP), fibrinogen, tissue plasminogen activator (tPA), D-dimer and von Willebrand factor (vWF) at 45 years. TV-viewing was measured in six categorises from none to >4 h /day. Sitting at work was measured as a continuous variable. Analysis adjusted for confounding factors (birth-weight, long-term illness, smoking, drinking, diet, social class and concurrent moderate/vigorous leisure-time PA). We assessed whether associations were mediated by body mass index (BMI). Inverse probability weights were used to account for attrition. Analysis was separate for males (n=4632) and females (n=4665). Results Men had higher total cholesterol, LDL, triglycerides, BP, HbA1c, tPA and vWF compared to women. Both genders had similar TV-viewing patterns, but men spent more time sitting at work. Preliminary analysis suggests that TV-viewing was consistently associated with adverse biomarker levels, usually with a stronger trend in women than men. For example increasing by a category of TV-viewing was linked to an unadjusted 11.0% (95% CI: 6.9% to 15.1%) increase in CRP in men and a 22.3% (95% CI: 18.0% to 26.6%) increase in women. Adjustment attenuated the relationships slightly to a 5.5% (95% CI: 1.3% to 9.8%) increase in men and a 18.1% (95% CI: 13.6% to 22.6%) increase in women. Associations with sitting were less consistent. After adjustment, sitting at work for 1–2, 2–3 and >3 h/day compared to <1 h/day, was linked to CRP increasing by -3.1% (95% CI: −19.7% to 13.6%), −6.8% (−22.9% to 9.3%) and 5.5% (95% CI: −6.3% to 17.3%) respectively for men and by −20.7% (95% CI: −40.4% to −1.0%), 1.3% (−16.7% to 19.3%) and 7.9% (−8.1% to 23.8%) respectively for women. Results, particularly for TV-viewing in women, were not wholly mediated by BMI. Conclusions Two indicators of sedentary behaviour show inconsistent associations with CVD biomarkers: TV-viewing shows strong trends, whereas trends for sitting at work are less consistent. The contrast between the two markers of sedentary behaviour brings into question the role of sedentary behaviour and its measurement in relation to CVD risk.
Circulating resistin concentration associates strongly with post-prandial plasma glucose in newly diagnosed Bangladeshi type 2 diabetic patients

Background and Aim: Adipocytokine, resistin, has proposed link with obesity-related insulin resistance (IR) and type 2 diabetes mellitus. This study aims to evaluate serum resistin in newly diagnosed T2DM subjects with different body mass index (BMI) groups. Subjects and Methods: A total of 147 newly diagnosed T2DM subjects were recruited in this study. Anthropometric indices were measured using standard techniques. Insulin and resistin were measured by enzyme-linked immunosorbent assay method. Insulin secretory capacity homeostasis model assessment (HOMA) beta and insulin sensitivity (HOMA%S) were calculated using fasting glucose and insulin by HOMA-CIGMA software. SPSS for windows was used for statistical analysis. Results: The subjects were divided into three groups on the basis of BMI cut-off points suggested by WHO for the Asian population (Group 1: BMI 18.5-23, Group 2: BMI 23.1-27.5, Group 3: BMI >27.5). Resistin was significantly higher in Group 3 compared with Group 1 and Group 2. HOMA%S was significantly lower in Group 3 compared to Group 1 and Group 2. When the subjects were categorized in three tertiles according to resistin values, HOMA%S was significantly lower in 3 rd tertile compared to 1 st tertile. In multiple linear regression analysis, both BMI and post-prandial serum glucose were significantly associated with serum resistin level, but that of the latter one was stronger. Conclusions: (a) BMI positively and insulin sensitivity inversely associates with serum resistin concentration, and (b) post-prandial hyperglycemia shows a positive and independent association with serum resistin.
Near-threshold voltage (NTV) design — Opportunities and challenges

Moore's Law will continue providing abundance of transistors for integration, only to be limited by the energy consumption. Near threshold voltage (NTV) operation has potential to improve energy efficiency by an order of magnitude. We discuss design techniques necessary for reliable operation over a wide range of supply voltage - from nominal down to subthreshold region. The system designed for NTV can dynamically select modes of operation, from high performance, to high energy efficiency, to the lowest power.
Process Mining: Overview and Opportunities

Over the last decade, process mining emerged as a new research field that focuses on the analysis of processes using event data. Classical data mining techniques such as classification, clustering, regression, association rule learning, and sequence/episode mining do not focus on business process models and are often only used to analyze a specific step in the overall process. Process mining focuses on end-to-end processes and is possible because of the growing availability of event data and new process discovery and conformance checking techniques. Process models are used for analysis (e.g., simulation and verification) and enactment by BPM/WFM systems. Previously, process models were typically made by hand without using event data. However, activities executed by people, machines, and software leave trails in so-called event logs. Process mining techniques use such logs to discover, analyze, and improve business processes. Recently, the Task Force on Process Mining released the Process Mining Manifesto. This manifesto is supported by 53 organizations and 77 process mining experts contributed to it. The active involvement of end-users, tool vendors, consultants, analysts, and researchers illustrates the growing significance of process mining as a bridge between data mining and business process modeling. The practical relevance of process mining and the interesting scientific challenges make process mining one of the “hot” topics in Business Process Management (BPM). This article introduces process mining as a new research field and summarizes the guiding principles and challenges described in the manifesto.
Serum Total Protein and Albumin Levels in Different Grades of Protein Energy Malnutrition

The present study has been designed to estimate serum total protein and albumin levels in different grades of protein energy malnutrition and this will be helpful in early diagnosis, management and rehabilitation of PEM. The serum total protein and albumin levels were studied on 20 healthy children and 30 children suffering from protein energy malnutrition of different grades. Serum total protein and albumin levels of different grades of protein energy malnutrition were significantly lowered than that of control. Lowering being maximum in grade III PEM. This lowering of total protein and albumin occur in any form of PEM and related to severity of the disease. doi: 10.3329/jbsp.v3i0. 1799 J Bangladesh Soc Physiol.2008 Dec;(3):58-60.
Systematic review of stroke thrombolysis service configuration

Intravenous recombinant tissue plasminogen activator is a highly effective treatment for acute ischemic stroke, but routine provision is challenging. We compared the activity, safety and response times of five service configurations: local services, redirection of selected or all suspected stroke patients by emergency medical services (EMS) to stroke centers and the use of telemedicine with and without secondary transfer to a stroke center. In total, 59 relevant service descriptions were identified. Pooled treatment rates (mean ± standard deviation [SD]) per 100 confirmed stroke patients were: local service design, 2.5 ± 2.5 (n = 21417); EMS redirection of only patients potentially eligible for thrombolysis, 3.9 ± 1.2 (n = 1872); EMS redirection of all suspected stroke patients, 3.8 ± 1.1 (n = 5427); telemedicine with secondary transfer, 6.9 (no pooled SD; n = 749); and telemedicine without secondary transfer, 3.4 (no pooled SD; n = 6610). A comprehensive stroke patient register was completed for only five regional collaborations, resulting in pooled ischemic stroke treatment rates of 5.7 (95% confidence interval: 4.6–6.9; n = 7815) compared with 3.1 (95% confidence interval: 2.1–4.1; n = 31411) for local services. Pooled symptomatic hemorrhage rates were similar for all service designs (range: 3.9–5.1%). Average door–needle times exceeded 60 min in most studies. We conclude that regional collaborations achieve higher rates of thrombolysis than local services working in isolation. Stroke services should continue to publish thrombolysis activity and safety data in a recommended format in order to determine the most suitable configuration for different settings.
Sentiment analysis: what is the end user's requirement?

In this paper we address the Sentiment Analysis problem from the end user's perspective. An end user might desire an automated at-a-glance presentation of the main points made in a single review or how opinion changes time to time over multiple documents. To meet the requirement we propose a relatively generic opinion 5Ws structurization, further used for textual and visual summary and tracking. The 5W task seeks to extract the semantic constituents in a natural language sentence by distilling it into the answers to the 5W questions: Who, What, When, Where and Why. The visualization system facilitates users to generate sentiment tracking with textual summary and sentiment polarity wise graph based on any dimension or combination of dimensions as they want i.e. "Who" are the actors and "What" are their sentiment regarding any topic, changes in sentiment during "When" and "Where" and the reasons for change in sentiment as "Why".