Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive Group Consensus of Multi-Agent Networks via Pinning Control

This paper studies the group consensus problem in networks of multi-agent systems, in which the nonlinear dynamics of all agents are unknown and nonidentical. We assume that the unknown dynamics are linearly parameterized. Adaptive control method is adopted in the algorithm design. A novel algorithm is proposed for the multi-agent systems to reach group consensus via pinning control strategies, which only rely on the relative position information between neighboring agents. The stability and parameter convergence analysis are done based on Lyapunov theory, Barbalat's lemma, adaptive control theory and algebraic graph theory. Finally, a simulation example is given to validate our theoretical results.
Wahrnehmung von Biotinmangel durch Saccharomyces cerevisiae

Biotin ist ein wasserlosliches Vitamin, es kann von fast allen S. cerevisiae-Stammen nicht de novo synthetisiert werden und dient als prosthetische Gruppe bei Carboxylierungsreaktionen. Es war bekannt, dass die Backerhefe bei einem Mangel an Biotin mit einer Expressionssteigerung des Biotintransportergens VHT1 reagiert [Stolz et al. (1999), J Biol Chem 274, 18741-18746]. Mit Hilfe von Sequenzvergleichen konnte in dieser Arbeit in den Promotoren der meisten Gene aus dem Biotinmetabolismus ein konserviertes palindromisches DNA-Element identifiziert werden. Dieses ist als UASBIO notwendig und hinreichend fur eine biotinabhangige Regulation. Western Blot- und Reportergenanalysen, untermauert durch Daten aus Microarray- und Nothern Blot-Experimenten, zeigten auserdem, dass neben VHT1 auch die anderen Gene des Biotinmetabolismus bei Biotinmangel aktiviert werden. Der Plasmamembrantransporter Vht1p ist nicht an der Wahrnehmung von Biotin beteiligt. Deletionsmutanten wiesen zwar eine Aktivierung der biotinregulierten Gene auf, dieser Effekt war aber nach der Gabe von Biotinvorstufen, die unabhangig von Vht1p aufgenommen und intrazellular in Biotin umgewandelt werden, nicht langer zu beobachten. Dabei wurde auch die Wahrnehmung extrazellularen Biotins ausgeschlossen. Im Gegensatz zur Situation beim Ausfall anderer biotintragender Proteine wurde ein Biotinmangelsignal bei einer Deletion beider Pyruvatcarboxylasen, Pyc1p und Pyc2p, komplett verhindert. Somit sind die Pyruvatcarboxylasen essentiell fur die Wahrnehmung von Biotin. Der genaue Funktionsmechanismus konnte allerdings noch nicht geklart werden. Aufgrund dieses Resultats wurde aber neben Vht1p auch der Biotin-Protein-Ligase Bpl1p, einem essentiellen Enzym, welches Biotin auf die Zielproteine ubertragt, nur eine indirekte Rolle in der Biotinwahrnehmung zugeschrieben. Wie bei vht1(delta)-Mutanten zeigten bpl1-Mutanten ebenfalls eine deutliche Expressionssteigerung der Biotingene, besasen aber im Gegensatz zu vht1(delta)-Mutanten normale Konzentrationen an freiem intrazellularen Biotin. Dieses ist deshalb fur die Wahrnehmung von Biotinmangel nicht relevant. Um unbekannte Glieder der Biotinsignalkette zu finden, wurde zum einen ein Reporterstamm mit EMS mutagenisiert und zum anderen mit einer multi-copy Genbank transformiert. Es konnten jeweils Klone mit einem konstitutiven Biotinmangelsignal (BHB, �blind for high biotin�) isoliert werden. Nach verschiedenen Tests zur Charakterisierung der Mutanten stehen 15 EMS-Klone fur nachfolgende Komplementationstests zur Verfugung. Im anderen Ansatz konnte fur keines der sequenzierten Genbankplasmide eine Beteiligung in der Biotinsignalkette nachgewiesen werden. Nichtsdestotrotz zeigt die hier erfolgte Identifizierung von TIS11, dem Gen eines eisenabhangigen Regulatorproteins, eine weitere interessante Verbindung von Biotin- und Eisenmetabolismus auf.
Comparison Study of Peptide Retention Time Prediction Model Based on Five Kinds of Amino Acid Descriptors in HPLC by Support Vector Machine

Based on amino acid descriptors(z-scales, c-scales, ISA-ECI,MS-WHIM and PRIN) and additive method, evaluation of predict performance of five amino acid descriptors in peptide QSRR(Quantitative structure-retention relationships) with 101 promiscuous peptides in High-Performance Liquid Chromato- graphy by support vector regression(SVR) is made in the article, and RBF(radical basis function) is selected as kernel function. Using leave-one-out cross-validation (LOO-CV), we suppose that predicting accuracy of ISA-ECI is better than the other descriptors in SVR with RBF. The prediction correlation coefficient of the SVR model (&#949; = 0.001,&#963;= 5 and C= 100) is 0.8445 by leave-one-out cross validation. The standard error of prediction (SEP) error of the dataset is 1.03 by fitting calculation, and the prediction correlation coefficient is 0.9642. The prediction results are in agreement with the experimental values. This paper provided a simple and effective method for predicting the retention behavior of peptide and some insight into what structural features are related to the retention time of peptides. Moreover, it also offered an idea about nonlinear relation between retention time of peptides and their structural descriptors (ISA-ECI). Therefore, SVR is assumed to be a feasible method in peptide QSAR (Quantitative structure-activity relationships) model.
Hip Arthroscopic Surgery

Arthroscopic surgery in the hip joint has historically lagged behind its counterparts in the shoulder and knee. However, the management of hip injuries in the athletic population has rapidly evolved over the past decade with our improved understanding of mechanical hip pathology as well as the marked improvement in imaging modalities and arthroscopic techniques. Current indications for hip arthroscopic surgery may include symptomatic labral tears, femoroacetabular impingement (FAI), hip capsular laxity/instability, chondral lesions, disorders of the peritrochanteric or deep gluteal space, septic joint, loose bodies, and ligamentum teres injuries. Furthermore, hip arthroscopic surgery is developing an increasingly important role as an adjunct diagnostic and therapeutic tool in conjunction with open femoral and/or periacetabular osteotomy for complex hip deformities. Arthroscopic techniques have evolved to allow for effective and comprehensive treatment of various hip deformities. Techniques for extensile arthroscopic capsulotomies have allowed for improved central and peripheral compartment exposure and access for labral takedown, refixation, treatment of chondral injury, and osteochondroplasty of the femoral head-neck junction and acetabular rim. While favorable short-term and midterm clinical outcomes have been reported after arthroscopic treatment of prearthritic hip lesions, greater long-term follow-up is necessary to assess the efficacy of hip arthroscopic surgery in altering the natural history and progressive degenerative changes associated with FAI.
Type systems for coordination languages

S-Net is a declarative coordination language rooted in stream processing with a runtime that automatically distributes the computational units among available resources. It is conceived in response to the change of processor development trend, from making the speed faster to embedding more cores. For performance reasons, the S-Net compiler is responsible for generating some additional information, through type inference, which is used by the runtime to make data delivery decisions. This requires the compiler to be supported by a sound type system which can ensure that the program behaviour meets the expectations of the language designers and the programmers. However, due to S-Net's design principle of ease of use, the S-Net type system was believed to be simple and was only informally documented. As we empirically tested the type inference implementation, we gradually revealed the hidden complexity of the calculus behind the apparently easy-to-use language, which was clearly beyond the capability of the informal type system. We then attempted several formulations of the type system, each addressing more issues we have found, but a complete solution was still missing. S-Net now urgently needs a formal type system with proofs of soundness. We have identi ed a major issue which has been making it di cult to design a correct type system, that is the type-semantics interdependency. In this thesis, we present a new design of the S-Net semantics and type system with no type-semantics interdependency, in terms of a new language BL-Net, a reduced S-Net which preserves only the type-related behaviour, which has an operational semantics re ecting that of S-Net, and a type system with the soundness and completeness proof. Our contributions also include a bridging solution to t the new type system into the existing compiler structure.
Iodine in the diet: Perspectives for vegans

Nutrition Research Centre, South Bank University, 103 Borough Road, London SE1 0AA IlltfOIIUCtl011 The majority of people consume an omnivorous diet although the acceptance of vegetarian and strict vegetarian (vegan) diets is increasing. Various nutrient deficiencies associated with these diets have been thoroughly investigated, although iodine intakes in these groups, and particularly in vegans, have so far been overlooked.
Role of Drosophila HP1 in euchromatic gene expression

Heterochromatin protein 1 (HP1), a gene silencing protein, localizes to centric heterochromatin through an interaction with methylated K9 of histone H3, a modification generated by the histone methyl transferase SU(VAR)3‐9. On Drosophila polytene chromosomes, HP1 also localizes to 200 sites scattered throughout euchromatin. To address the role of HP1 in euchromatic gene regulation, mRNAs from wild‐type and Su(var)2‐5 mutants lacking HP1 were compared. Genes residing within a 550‐kb genomic region enriched in HP1 that show altered expression in the Su(var)2‐5 mutant were analyzed in detail. Three genes within this region, Pros35, CG5676, and cdc2, were found to associate with HP1 by chromatin immunoprecipitation. Surprisingly, these genes require HP1 for expression, suggesting a positive role for HP1 in euchromatic gene expression. Of these genes, only cdc2 is packaged with methylated K9 H3. Furthermore, none of the genes show altered expression in a Su(var)3‐9 mutant. Collectively, these data demonstrate multiple mechanisms for HP1 localization within euchromatin and show that some genes associated with HP1 are not affected by alterations in Su(var)3‐9 dosage. Developmental Dynamics 232:767–774, 2005. © 2005 Wiley‐Liss, Inc.
Automated Epileptic Seizure Detection Based on Wearable ECG and PPG in a Hospital Environment

Electrocardiography has added value to automatically detect seizures in temporal lobe epilepsy (TLE) patients. The wired hospital system is not suited for a long-term seizure detection system at home. To address this need, the performance of two wearable devices, based on electrocardiography (ECG) and photoplethysmography (PPG), are compared with hospital ECG using an existing seizure detection algorithm. This algorithm classifies the seizures on the basis of heart rate features, extracted from the heart rate increase. The algorithm was applied to recordings of 11 patients in a hospital setting with 701 h capturing 47 (fronto-)temporal lobe seizures. The sensitivities of the hospital system, the wearable ECG device and the wearable PPG device were respectively 57%, 70% and 32%, with corresponding false alarms per hour of 1.92, 2.11 and 1.80. Whereas seizure detection performance using the wrist-worn PPG device was considerably lower, the performance using the wearable ECG is proven to be similar to that of the hospital ECG.
Methanosarcinaceae and Acetate-Oxidizing Pathways Dominate in High-Rate Thermophilic Anaerobic Digestion of Waste-Activated Sludge

ABSTRACT This study investigated the process of high-rate, high-temperature methanogenesis to enable very-high-volume loading during anaerobic digestion of waste-activated sludge. Reducing the hydraulic retention time (HRT) from 15 to 20 days in mesophilic digestion down to 3 days was achievable at a thermophilic temperature (55°C) with stable digester performance and methanogenic activity. A volatile solids (VS) destruction efficiency of 33 to 35% was achieved on waste-activated sludge, comparable to that obtained via mesophilic processes with low organic acid levels (<200 mg/liter chemical oxygen demand [COD]). Methane yield (VS basis) was 150 to 180 liters of CH4/kg of VSadded. According to 16S rRNA pyrotag sequencing and fluorescence in situ hybridization (FISH), the methanogenic community was dominated by members of the Methanosarcinaceae, which have a high level of metabolic capability, including acetoclastic and hydrogenotrophic methanogenesis. Loss of function at an HRT of 2 days was accompanied by a loss of the methanogens, according to pyrotag sequencing. The two acetate conversion pathways, namely, acetoclastic methanogenesis and syntrophic acetate oxidation, were quantified by stable carbon isotope ratio mass spectrometry. The results showed that the majority of methane was generated by nonacetoclastic pathways, both in the reactors and in off-line batch tests, confirming that syntrophic acetate oxidation is a key pathway at elevated temperatures. The proportion of methane due to acetate cleavage increased later in the batch, and it is likely that stable oxidation in the continuous reactor was maintained by application of the consistently low retention time.
Performance Evaluation of Block-Type and Comb-Type Channel Estimation for OFDM System

In order to achieve the potential advantages of Orthogonal Frequency Division Multiplexing (OFDM) based systems, the channel coefficients should be estimated with minimum error. Channel estimation plays a vital role in OFDM system. The channel estimation technique for OFDM systems based on block and Comb pilot arrangements are investigated. The Performance comparison of Least Square, Minimum Mean Square and Least Mean Square error estimation algorithm by measuring bit error rate under different modulation techniques like Binary Phase Shift Keying (BPSK), Quadrature Phase Shift Keying (QPSK), and Quadrature Amplitude Modulation (QAM) is carried out both Block and Comb pilot based arrangement. In order to model the effect of a propagation environment under radio signal Rayleigh fading has been considered along with Additive White Gaussian Noise (AWGN). With different modulation schemes and channel estimation algorithm shows better results and improvement in terms of Bit Error Rate (BER).
Five good reasons to abandon synchronous time control

Time control maintains the average electrical frequency to its nominal value over the long run. This control currently suffers from numerous accepted beliefs that are deemed to justify this practice. This paper discusses these beliefs and highlights various reasons in favor of abandoning time control. In particular, time control exhibits a limited value compared to increased costs due to a higher operation complexity and a lower security. If time control has to be kept, this paper shows that current operational procedures should at least be improved in order to increase system security.
Exploiting Properties of CMP Cache Traffic in Designing Hybrid Packet/Circuit Switched NoCs

Chip multiprocessors with few to tens of processing cores are already commercially available. Increased scaling of technology is making it feasible to integrate even more cores on a single chip. Providing the cores with fast access to data is vital to overall system performance. When a core requires access to a piece of data, the core's private cache memory is searched first. If a miss occurs, the data is looked up in the next level(s) of the memory hierarchy, where often one or more levels of cache are shared between two or more cores. Communication between the cores and the slices of the on-chip shared cache is carried through the network-on-chip(NoC). Interestingly, the cache and NoC mutually affect the operation of each other; communication over the NoC affects the access latency of cache data, while the cache organization generates the coherence and data messages, thus affecting the communication patterns and latency over the NoC. This thesis considers hybrid packet/circuit switched NoCs, i.e., packet switched NoCs enhanced with the ability to configure circuits. The communication and performance benefit that come from using circuits is predicated on amortizing the time cost incurred for configuring the circuits. To address this challenge, NoC designs are proposed that take advantage of properties of the cache traffic, namely temporal locality and predictability, to amortize or hide the circuit configuration time cost. First, a coarse-grained circuit configuration policy is proposed that exploits the temporal locality in the cache traffic to periodically configure circuits for the heavily communicating nodes. This allows the design of a locality-aware cache that promotes temporal communication locality through data placement, while designing suitable data replacement and migration policies. Next, a fine-grained configuration policy, called Deja Vu switching, is proposed for leveraging predictability of data messages by initiating a circuit configuration as soon as a cache hit is detected and before the data becomes available. Its benefit is demonstrated for saving interconnect energy in multi-plane NoCs. Finally, a more proactive configuration policy is proposed for fast caches, where circuit reservations are initiated by request messages, which can greatly improve communication latency and system performance.
Effect of age at first calving on first lactation milk yield in Holstein cows from Costa Rican specialized dairy herds.

In order to determine the effect of age at first calving (AFC) at 305-d milk yield, a historical prospective longitudinal study of 46,029 pure specialized dairy Costa Rican Holstein animals was carried out between 2000 and 2010. Data on purebred specialized dairy Holstein cows enrolled in the program VAMPP Bovino 3.0 were included. Information was analyzed by using descriptive statistics and mixed linear models. The effect of the AFC was adjusted to the ecological zone, season of birth, year of birth, inbreeding index, and type of parturition and parity number of the dam at birth. The average AFC for the animals that were part of the study was 30.7 mo (SD: 6.8, 95% CI: 30.6 - 30.7). The average total milk production in the first lactation was5188.0 kg(95% CI: 5153.4 - 5223.2), whereas the 305-d corrected milk yield resulted in5288 kg(95% CI: 5253.7 - 5323.2). Cows with AFC less than 26 mo and between 26.0 and 33.6 mo, produced -354.8 kg/305-d (P < 0.0001) and -105.6 kg/305-d (P = 0.0117) respectively, compared with cows calving over 33.6 mo. It is likely that the observed effect of the AFC on the topmost dairy lactation affects the productive life of the cow within the herd. Further studies are required to prove this hypothesis.
Distinct Roles for the Catalytic and Hemopexin Domains of Membrane Type 1-Matrix Metalloproteinase in Substrate Degradation and Cell Migration*

Substrate degradation and cell migration are key steps in cancer metastasis. Membrane-type 1-matrix metalloproteinase (MT1-MMP) has been linked with these processes. Using the fluorescein isothiocyanate (FITC)-labeled fibronectin degradation assay combined with the phagokinetic cell migration assay, structure-function relationships of MT1-MMP were studied. Our data indicate that MT1-MMP initiates substrate degradation and enhances cell migration; cell migration occurs as a concurrent but independent event. Using recombinant DNA approaches, we demonstrated that the hemopexin-like domain and a nonenzymatic component of the catalytic domain of MT1-MMP are essential for MT1-MMP-mediated cell migration. Because the cytoplasmic domain of MT1-MMP was not required for MT1-MMP-mediated fibronectin degradation and cell migration, it is proposed that cross-talk between the hemopexin domain of MT1-MMP and adjacent cell surface molecules is responsible for outside-in signaling. Employing cDNAs encoding dominant negative mutations, we demonstrated that Rac1 participates in the MT1-MMP signal transduction pathway. These data demonstrated that each domain of MT1-MMP plays a distinct role in substrate degradation and cell migration.
The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components

The bacterial septum appears to comprise a macromolecular assembly of essential cell division proteins (the ‘septasome’) that are responsible for physically dividing the cell during cytokinesis. FtsL and DivIC are essential components of this division machinery in Bacillus subtilis. We used yeast two‐hybrid analysis as well as a variety of biochemical and biophysical methods to examine the proposed interaction between Bacillus subtilis FtsL and DivIC. We show that FtsL and DivIC are thermodynamically unstable proteins that are likely to be unfolded and therefore targeted for degradation unless stabilized by interactions with other components of the septasome. However, we show that this stabilization does not result from a direct interaction between FtsL and DivIC. We propose that the observed interdepend‐ence of DivIC and FtsL stability is a result of indirect interactions that are mediated by other septasomal proteins.
Rôle des oscillations corticales dans l'asymétrie fonctionnelle du traitement de la parole

Le traitement de la parole est reparti entre les deux hemispheres avec une dominance gauche pour la comprehension verbale et une lateralisation droite relative aux traitements de l’intonation et de la reconnaissance du locuteur. La theorie de l’echantillonnage asymetrique (AST) stipule qu’une difference de sensibilite des neurones des cortex auditifs gauche et droit suffirait a expliquer la lateralisation du langage. Des fenetres d’echantillonnages contraignant le traitement de l’information selon un rythme phonemique a gauche et syllabique a droite seraient soutenus par une activite oscillatoire a un rythme gamma (~40 Hz) et theta (~5 Hz), respectivement. Le but de cette these etait de confirmer et d’etendre les predictions faites par l’AST a travers deux etudes. L’enregistrement intracranien EEG dans les cortex auditif bilateraux a permis d’etablir que : (i) le signal acoustique est echantillonne selon les rythmes phonemique et syllabique dans les cortex auditif primaire gauche et secondaire droit, respectivement ; (ii) leur integration aboutirait a la formation d’un rythme syllabique interne dans le cortex auditif associatif gauche ; (iii) ces patterns oscillatoires sont retrouves dans l’activite spontanee mesuree pendant l’etat de repos, avec une specificite frequentielle et spatiale. L’enregistrement EEG/IRMf combine de l’ensemble du cortex a revele que : (i) les cortex auditif primaire, mais aussi moteur articulatoire, somatosensoriel et inferieur parietal presentent une activite oscillatoire asymetrique au repos ; (ii) les aires de Wernicke et de Broca heritent leurs profils asymetriques lors d’un traitement linguistique ; (iii) les aires sensorielles et motrices influencent le reseau du langage principalement aux rythmes gamma et delta/theta, respectivement. Ainsi au cours de l’evolution les aires motrices et sensorielles se seraient renforcees mutuellement lors de la production verbale, organisant leur activite oscillatoire autour des rythmes theta et gamma.
GRAND ROUNDS: Topographical Heading Disorientation - A Case Study

We report the case of a patient with selective topographic orientation deficits in both familiar and novel environments after bilateral medial occipital infarctions. Extensive neuropsychological assessment revealed intact functioning in all other cognitive domains. The findings are interpreted in terms of a dissociation between the retrosplenial posterior cingulate and the superior parietal lobule in the right hemisphere.