Miracle-dz/UniFAR-FTUs huggingface dataset:
Breast cancer at extreme ages--a comparative analysis in Chile.

BACKGROUND Young onset breast cancer (BC) has a worse outcome as compared to in the elderly. However, some studies have shown that BC in the elderly, despite indolent features, does also cause increase in mortality. In an attempt to compare clinic-pathological characteristics, BC subtypes and survival in patients with BC presenting at extremes of age, we performed a retrospective study. MATERIALS AND METHODS Patients were either ≤40 or ≥70 years old. Subtypes were defined using immunohistochemistry and histological grade. Chi-Square test was used for evaluation of categorical variables, and Kaplan-meier and log-rank for disease-specific survival (DSS) and disease free survival (DFS) . RESULTS We analyzed 256 patients ≤40 and 366 patients ≥70. Younger patients presented with more aggressive disease, with less luminal A but more luminal B and triple negative (TN) subtype. With a median follow-up of 57.5 months, DFS at 5 years in younger patients was 72.3% vs 84.6% in the elderly (p=0.007). Luminal A and B disease presented with worse DFS in younger patients. The opposite was seen in the TN subgroup. Although we found no significant differences in DSS, older patients with TN tumors died of BC more frequently. This group also received less chemotherapy. CONCLUSIONS Young patients present with more aggressive disease, this translating into worse DFS. However, elderly patients with TN disease represent a particular subpopulation with worse DFS and DSS, suggesting that chemotherapy should not be withheld only because of age.
Pharmacokinetic Considerations in Prescribing Antiepileptic Drugs

Summary: Each antiepileptic drug has a characteristic pharmacokinetic profile, and the unique properties of each must be considered when selecting the optimal agent for a particular patient. Detailed pharmacologic data are obtained during the preapproval evaluation of a drug, particularly in early phase studies in healthy volunteers. Each drug is then evaluated in the target population in later phase trials and in certain populations, such as children and individuals with various types of organ failure. Key considerations are bioavailability, protein binding, metabolism and elimination, and drug interactions. Important pharmacokinetic considerations in the selection and use of these drugs are presented in this review, with examples from currently available drugs.
The Silent Danger Related to Patient Positioning and Surgery

Compartment syndrome affecting the limbs is a well-documented condition and there are cases where it has become evident following surgery undertaken with the patient in the Lloyd Davies position. This article explores the contributory factors and the devastating effect it can have on the patient, and questions whether we practise evidence-based care when patients are undergoing certain types of surgery. It also discusses factors related to abdominal compartment syndrome, a condition usually affecting the critically ill patient.
Echocardiographic evaluation of left ventricular diastolic function: correlation between echocardiographic and hemodynamic parameters.

AIM The aim of this study was to assess the correlation between non invasive echo-Doppler parameters of diastolic function and invasively measured end-diastolic left ventricular (LV) filling pressures in patients with normal or depressed LV function. METHODS The patient population was composed of 44 subjects, (34 men and 10 women) 52% with normal ventricular function, who underwent echo-Doppler and hemodynamic evaluation within 24 hours between the two exams. RESULTS LV end-diastolic pressure was statistically different (P=0.022) in the 4 subgroups divided on the basis of the mitral flow pattern in the overall population and in the patients with depressed LV function, but not in those with normal LV function. In the overall population LV end-diastolic pressure was significantly correlated with: 1) E/A ratio of mitral flow (r=0.45, P=0.002); 2) mitral E wave peak velocity (r=0.39, P=0.017); 3) isovolumic relaxation time (r=-0.34, P=0.01); 4) left atrial diameter (r=0.33, P=0.037); 5) duration of retrograde A wave of pulmonary venous flow (r=0.33, P=0.03); 6) Pulmonary vein D wave peak velocity (r=0.29, P=0,05). Multivariate analysis showed that the correlation between the echo-Doppler variables and LV end-diastolic pressure was statistically significant only in patients with depressed LV function, but not in those with normal function. CONCLUSION Among the echo-Doppler variables examined, those derived from transmitral flow and pulmonary vein flow show the best correlation with left ventricular end-diastolic pressure; however, the correlation is statistically significant only in patients with depressed LV function. Thus, the echo-Doppler evaluation of LV diastolic function should take into account this limitation and should be based on a multiparametric approach.
Preserved Adjustment but Impaired Awareness in a Sensory-Motor Conflict following Prefrontal Lesions

Control of action occurs at different stagesof the executive process, in particular at those of sensory-motor integration and conscious monitoring. The aim of this study was to determine the implication of the prefrontal cortex in the control of action. For that purpose, we compared the performance of 15 patients with frontal lobe lesions and 15 matched controls on an experimental paradigm generating a conflict between the action planned and the sensory-motor feedback. Subjects had to trace a sagittal line witha stylus on a graphic tablet. The hand was hidden by a mirror on which the traced line, processed by a computer, was projected. Without informing the subjects, the line traced was modified by introducing a bias to the right, which increased progressively from 2 to 42. To succeed the task, subjects had to modify their motor program and deviate their hand in the opposite direction. The sensory-motor adjustment to the bias was evaluated by the surface between the line traced and the ideal line to compensate for the deviation. The awareness of the conflict was measured by the angle of the bias at which subjects expressed the feeling that the line they traced was not the same as the line they saw. The deviation was similarly compensated for by patients and controls until24. Then 14 controls but only3 patients were aware of a conflict. After that, the variability of performance increased significantly for the unaware patients. These results suggest that the prefrontal cortex is required at the level of conscious monitoring of actions, but not at the level of sensory-motor integration.
High-Capacity Chipless RFID Tag Insensitive to the Polarization

Designing a reader for chipless RFID is a hard task since both the polarization and operating frequency agility have to be implemented. The new tag design proposed in this paper is polarization independent, making the design of the reader easier since only linear polarization is needed to detect the tag. The proposed chipless tag is based on multiple circular ring patch resonators. The coding capacity of this tag reaches 19 bits within a compact surface of cm . Further, the frequency band is within 3.1 to 10.6 GHz to be compliant with FCC and ECC regulations for UWB. This new design is experimentally validated in the frequency domain using bi-static measurement set-up. Both amplitude and group delay responses of the tag are investigated and carried out.
Silicon Monolithic Millimeterwave Integrated Circuits

Silicon monolithic millimeterwave integrated circuits (SIMMWICs) for frequencies up to above 100 GHz are discussed. In silicon circuits IMPATT diodes may be used as the active devices whereas mixer and detector circuits may be realized with Schottky diodes. IMPATT diodes as well as Schottky diodes may be integrated in planar monolithic silicon technology. In the frequency region above 60 GHz planar antenna structures may be integrated within monolithic silicon circuits. The design and the relization of planar millimeterwave circuits on silicon, including also antenna structures are discussed. Experimental results with different millimeterwave integrated circuits are presented. With planar silicon IMPATT oscillators above 70 GHz cw output power of 200 mW has been achieved. A monolithic 93 GHz receiver with a planar 36 element antenna on a 5, 4 * 5, 6 mm2 silicon substrate has a sensitivity of 65¿V¿W¿1cm2. An outlook on future applications of SIMMWICs is given.
Secrecy Outage of Dual-Hop AF Relay System With Relay Selection Without Eavesdropper's CSI

We evaluate the upper bound, lower bound and an approximate expression for secrecy outage probability of a dual hop Amplify-and-forward (AF) relay system when the single cooperating relay among the relays is selected without the knowledge of eavesdropper's instantaneous channel state information (CSI). This situation arises when eavesdropper is not a legitimate node, or being a trusted node, it acts maliciously and does not share its instantaneous CSI. We also obtain the tighter bounds in high signal-to-noise ratio (SNR) of the source to relay links and in high SNR of the relay to destination links. We show that when the SNR of the source to relay links tends to zero, it becomes the bottle neck for secure communication, and the secrecy outage tends to 1. We show that the approximate expression follows the simulated outage closely and the outage decreases with an increase in the number of relays and increases with an increase in the required secrecy rate.
A novel framework for visuo-haptic percutaneous therapy simulation based on patient-specific clinical trials

Percutaneous therapy is a common clinical operation in minimally invasive surgery. Yet, learning curve of this skillful manual operation is steep, which imposes negative impacts on its further advances. In this paper, we proposed a novel workflow to simulate percutaneous therapy through visuo-haptic rendering based on the clinical trials. Intraoperative puncture data, obtained by our 6DOF force recording system in the operating room, is fitted as the original force model for the haptic rendering. Patient-specific medical images were also segmented and reconstructed for the highly immersive virtual training scenario. Last but not least, medical professors and novices have also been invited to practice on our training scenario by employed the Global Rating Scale (GRS) questionnaire and parameter metrics recording to validate framework's performance. Posttest values in experts and novices' groups after training showed great progress with respect to pretest values in both GRS scores and objective evaluation.
Probiotics and prebiotics in preventing food allergy and eczema

Purpose of reviewTo describe the current literature on clinical trials of probiotics for eczema and food allergy prevention in view of recent new approaches and long-term follow-ups. Recent findingsAttempting allergy prevention by probiotic administration has been most successful when assessing atopic eczema, the most prevalent allergic disease at an early age. More than half of the published studies demonstrate a decrease in eczema prevalence until 2 years, whereas the remaining studies fail to show an effect. Effects have been most consistent with combined prenatal and direct postnatal supplementation of the infant and appear strain-specific, with Lactobacillus rhamnosus most often showing an effect. Prenatal-only and postnatal-only studies often fail to show effects. Recent long-time follow-ups have shown promising but not consistent results. A very recent follow-up of a large well conducted cohort shows that long-term effects of eczema prevention persists until age 4 and prevention of respiratory allergies might also be possible. SummaryPrevention of eczema with probiotics seem to work until age 2 years and extended effects until 4 years have been shown in high-risk for allergy cohorts. Effects are strain-specific, with L. rhamnosus showing the most consistent effects especially when combining pre and postnatal administration.
Systematic Mutagenesis of Serine Hydroxymethyltransferase Reveals an Essential Role in Nematode Resistance1[OPEN]

A soybean serine hydroxymethyltransferase has a unique and essential role in soybean cyst nematode resistance. Rhg4 is a major genetic locus that contributes to soybean cyst nematode (SCN) resistance in the Peking-type resistance of soybean (Glycine max), which also requires the rhg1 gene. By map-based cloning and functional genomic approaches, we previously showed that the Rhg4 gene encodes a predicted cytosolic serine hydroxymethyltransferase (GmSHMT08); however, the novel gain of function of GmSHMT08 in SCN resistance remains to be characterized. Using a forward genetic screen, we identified an allelic series of GmSHMT08 mutants that shed new light on the mechanistic aspects of GmSHMT08-mediated resistance. The new mutants provide compelling genetic evidence that Peking-type rhg1 resistance in cv Forrest is fully dependent on the GmSHMT08 gene and demonstrates that this resistance is mechanistically different from the PI 88788-type of resistance that only requires rhg1. We also demonstrated that rhg1-a from cv Forrest, although required, does not exert selection pressure on the nematode to shift from HG type 7, which further validates the bigenic nature of this resistance. Mapping of the identified mutations onto the SHMT structural model uncovered key residues for structural stability, ligand binding, enzyme activity, and protein interactions, suggesting that GmSHMT08 has additional functions aside from its main enzymatic role in SCN resistance. Lastly, we demonstrate the functionality of the GmSHMT08 SCN resistance gene in a transgenic soybean plant.
Supporting temporal question answering: strategies for offline data collection

We pursue two strategies for offline data collection for a temporal question answering system that uses both quantitative methods and fuzzy methods to reason about time and events. The first strategy extracts event descriptions from the structured year entries in the online encyclopedia Wikipedia, yielding clean quantitative temporal information about a range of events. The second strategy mines the web using patterns indicating temporal relations between events and times and between events. Web mining leverages the volume of data available on the web to find qualitative temporal relations between known events and new, related events and to build fuzzy time spans for events for which we lack crisp metric temporal information.
Psychopathology in the children (ages 6-18) of depressed and normal parents.

Data from a pilot family-history study of 194 children (ages 6–18) of probands with major depression compared with the children of normal controls showed children of depressives were at increased risk for psychological symptoms, treatment for emotional problems, school problems, suicidal behavior, and DSM-III diagnoses. The magnitude of the risk was increased 3-fold for any DSM-III diagnosis in the children of depressed probands. Major depression was the most common psychiatric disorder, followed by attention deficit and separation anxiety. The risk to children of major depression and of any DSM-III diagnosis increased linearly if both parents were psychiatrically ill than if only one or neither parent had psychiatric illness. Other significant predictors of risk to children were early onset of the proband's depression, an increased number of the proband's first-degree relatives who were ill with any psychiatric disorder and/or major depression, and if the proband was divorced, separated or widowed. While diagnoses were based on multiple informants and were made by a psychiatrist who was blind to the clinical status of the probands, the absence of direct interviews with the children make these findings preliminary. A direct interview study is under way.
PV array characteristics analysis under partial shading & modeling of P&O MPPT applied boost convertor using Matlab/Simulink

This paper deals with analysis of a photovoltaic panel array characteristics by considering partial shading effects and modeling of perturb and observe MPPT (Maximum Power Point Tracking) algorithm applied boost convertor using Matlab/Simulink. Performance of a photovoltaic (PV) array is affected by temperature, solar insolation, shading and array configuration. Analysis of photovoltaic array characteristics plays an important role in developing an algorithm based devices for Maximum power point tracking (MPPT). Such devices play an important role in efficient usage of available solar energy. The analyzer developed in command window reads panel temperature, irradiance and number of cells exposed to light and generates corresponding PV characteristics. Maximum power point tracking algorithm is used to generate pulse width modulated signal for boost convertor thus extracting the maximum power from the solar PV module and transferring that power to the load. Perturb and observes algorithm is used, which is the simplest algorithm for implementation.
Safelnit: Comprehensive and Practical Mitigation of Uninitialized Read Vulnerabilities

Usage of uninitialized values remains a common error in C/C++ code. This results not only in undefined and generally undesired behavior, but is also a cause of information disclosure and other security vulnerabilities. Existing solutions for mitigating such errors are not used in practice as they are either limited in scope (for example, only protecting the heap), or incur high runtime overhead. In this paper, we propose SafeInit, a practical protection system which hardens applications against such undefined behavior by guaranteeing initialization of all values on the heap and stack, every time they are allocated or come into scope. Doing so provides comprehensive protection against this class of vulnerabilities in generic programs, including both information disclosure and re-use/logic vulnerabilities. We show that, with carefully designed compiler optimizations, our implementation achieves sufficiently low overhead (<5% for typical server applications and SPEC CPU2006) to serve as a standard hardening protection in practical settings. Moreover, we show that we can effortlessly apply it to harden non-standard code, such as the Linux kernel, with low runtime overhead.
Advances in immunotherapy of hematologic malignancies: cellular and humoral approaches

Monoclonal antibodies have become an important modality for cancer therapy. Genetically engineered chimeric and humanized antibodies have demonstrated activity against overt lymphoma and leukemia, as well as minimal residual disease. Radioimmunotherapy in both nonmyeloablative and myeloablative regimens has produced significant responses and also minimized radiation exposure to normal tissues. Targeted &agr;-particle therapy offers the possibility of selective tumor cell kill. Antibody-drug conjugates have produced remissions in acute leukemia. Many proteins potentially act as leukemia or lymphoma-specific antigens for major histocompatibility complex–restricted T cell cytotoxicity. These include the idiotype proteins, breakpoint cluster region (bcr)-abl and other fusion oncoproteins, myeloid-specific differentiation antigens and minor histocompatibility antigens. Clinical trials exploiting the new understanding of the T cell immunology are underway.
The Giardia genome project database.

The Giardia genome project database provides an online resource for Giardia lamblia (WB strain, clone C6) genome sequence information. The database includes edited single-pass reads, the results of BLASTX searches, and details of progress towards sequencing the entire 12 million-bp Giardia genome. Pre-sorted BLASTX results can be retrieved based on keyword searches and BLAST searches of the high throughput Giardia data can be initiated from the web site or through NCBI. Descriptions of the genomic DNA libraries, project protocols and summary statistics are also available. Although the Giardia genome project is ongoing, new sequences are made available on a bi-monthly basis to ensure that researchers have access to information that may assist them in the search for genes and their biological function. The current URL of the Giardia genome project database is www.mbl. edu/Giardia.
BMP ligands act redundantly to pattern the dorsal telencephalic midline

The embryonic telencephalon is patterned into several areas that give rise to functionally distinct structures in the adult forebrain. Previous studies have shown that BMP4 and BMP2 can induce features characteristic of the telencephalic midline in cultured explants, suggesting that the normal role of BMP4 in the forebrain is to pattern the medial lateral axis of the telencephalon by promoting midline cell fates. To test this hypothesis directly in vivo, the Bmp4 gene was efficiently disrupted in the telencephalon using a CRE/loxP approach. Analysis of Bmp4‐deficient telencephalons fails to reveal a defect in patterning, cell proliferation, differentiation, or apoptosis. The absence of a phenotype in the Bmp4‐deficient telencephalon along with recent genetic studies establishing a role for a BMP4 receptor, BMPRIA, in telencephalic midline development, demonstrate that loss of Bmp4 function in the telencephalon can be compensated for by at least one other Bmp gene, the identity of which has not yet been determined. genesis 35:214–219, 2003. © 2003 Wiley‐Liss, Inc.
Signal Integrity Enhanced EBG Structure With a Ground Reinforced Trace

In general, a conventional electromagnetic bandgap (EBG) structure efficiently suppresses simultaneous switching noise (SSN) over a wide frequency range. However, it is difficult to apply the geometry to the design of a real printed circuit boards (PCBs) for high-speed digital circuits due to the degradation in the signal integrity performance. In this paper, a ground reinforced trace (GRT) is added to the EBG power plane to guarantee power integrity (PI) as well as signal integrity (SI) simultaneously. In addition, the definition of a noise suppression bandwidth in an EBG structure is derived for the purpose of analyzing the correlation between the GRT and the noise suppression bandwidth. This correlation is utilized to decide the location of the GRT to mitigate the degradation of the low-pass cutoff frequency. As a result, an excellent signal performance is achieved without any degradation of the noise suppression bandwidth in a conventional EBG structure.
Nonlocality and intermittency in three-dimensional turbulence

Numerical simulations are used to determine the influence of the nonlocal and local interactions on the intermittency corrections in the scaling properties of three-dimensional turbulence. We show that neglect of local interactions leads to an enhanced small-scale energy spectrum and to a significantly larger number of very intense vortices (“tornadoes”) and stronger intermittency (e.g., wider tails in the probability distribution functions of velocity increments and greater anomalous corrections). On the other hand, neglect of the nonlocal interactions results in even stronger small-scale spectrum but significantly weaker intermittency. Thus, the amount of intermittency is not determined just by the mean intensity of the small scales, but it is nontrivially shaped by the nature of the scale interactions. Namely, the role of the nonlocal interactions is to generate intense vortices responsible for intermittency and the role of the local interactions is to dissipate them. Based on these observations, a new.