Miracle-dz/UniFAR-FTUs huggingface dataset:
Primary cutaneous follicle center lymphoma associated with an extracutaneous dissemination: a cytogenetic finding of potential prognostic value.

OBJECTIVES Cytogenetic studies on cutaneous lymphomas are rare, and very little is known about their prognostic value. We present a rare case of primary cutaneous follicle center lymphoma (PCFCL) with a complex translocation presenting with cutaneous and extracutaneous dissemination in the lymph node. METHODS Morphologic, immunohistochemical, conventional cytogenetic, and fluorescence in situ hybridization (FISH) studies were performed on this patient. RESULTS A combination of cytogenetic and FISH analysis identified a complex novel four-way t(2;14;9;3) (p11.2;q32;p13;q27) translocation involving rearrangements of BCL6, immunoglobulin light and heavy chain genes, and an unknown gene on 9p. CONCLUSIONS Our report elaborates the morphologic and immunohistochemical features in combination with cytogenetic and molecular cytogenetic analysis of PCFCL, which provide additional insight into the clinical and biologic behavior of this lesion.
Developmental Plasticity in Cartesian Genetic Programming based Neural Networks

This work presents a method for exploiting developmental plasticity in Artificial Neural Networks using Cartesian Genetic Programming. This is inspired by developmental plasticity that exists in the biological brain allowing it to adapt to a changing environment. The network architecture used is that of a static Cartesian Genetic Programming ANN, which has recently been introduced. The network is plastic in terms of its dynamic architecture, connectivity, weights and functionality that can change in response to the environmental signals. The dynamic capabilities of the algorithm are tested on a standard benchmark linear/non-linear control problems (i.e. pole-balancing).
Physical Training and Noninvasive Ventilation in COPD Patients: A Meta-Analysis

BACKGROUND: Exercise training improves both exercise tolerance and quality of life in patients with COPD. The intensity of exercise training is crucial to achieve a true physiologic effect. However, in COPD patients, exertional dyspnea and leg fatigue mean that the patient cannot maintain intensity of training for enough time to yield a physiologic training effect. The use of noninvasive ventilation (NIV) support has been proposed as an alternative strategy to improve exercise tolerance and respiratory and cardiovascular performances. The first aim of our meta-analysis was to evaluate exercise training with NIV in terms of physiologic effects after the completion of a pulmonary rehabilitation program. The second aim was to investigate the dose-response relationship between physical improvement and training intensity. METHODS: Literature research was performed using MEDLINE, Embase, and CINAHL. Meta-analysis and meta-regressions were performed using random effects models. RESULTS: Eight studies provided a proper description of a training schedule in stable COPD patients. A similar effect between NIV and placebo was observed for the outcomes considered despite differences between studies. However, subjects experienced a relevant and statistically significant improvement after rehabilitation for almost all of the outcomes considered. Heart rate (6 beats/min [95% CI 0.94–11.01], P = .02), work load (9.73 W [95% CI 3.78–15.67], P < .001), and oxygen consumption (242.11 mL/min [95% CI 154.93–329.9], P < .001) significantly improved after training. Improvements in heart rate and work load were significantly correlated to training intensity. CONCLUSIONS: Given the small number of available studies, the small sample sizes, and the complete absence of power calculation, we think that this topic deserves a more in-depth investigation. Randomized clinical trials with larger sample sizes based on statistical power calculations and designed to investigate the effect of training duration and intensity on rehabilitation are needed to confirm results in this important field.
Dietary capsaicin ameliorates pressure overload-induced cardiac hypertrophy and fibrosis through the transient receptor potential vanilloid type 1.

BACKGROUND Dietary capsaicin plays a protective role in hypertension, atherosclerosis, obesity, and hyperlipidemia through activating the transient receptor potential vanilloid type 1 (TRPV1), a nonselective cation channel. This study was designed to investigate the role of capsaicin in cardiac hypertrophy and fibrosis in a pressure overload model. METHODS TRPV1 knockout (KO) mice and their wild-type (WT) littermates, aged 8 weeks, were randomly divided into sham and aortic banding surgery groups and were fed with chow or chow plus capsaicin for 10 weeks. RESULTS Dietary capsaicin significantly attenuates pressure overload-induced increase in heart weight index, enlargement of ventricular volume, decrease in cardiac function, and increase in cardiac fibrosis in WT mice. However, these effects of capsaicin were absent in TRPV1 KO mice. Additionally, capsaicin blunted pressure overload-induced upregulation of transforming growth factor β, connective tissue growth factor, and the phosphorylation of Smad2/3 in WT mice but not in TRPV1 KO mice. Moreover, capsaicin attenuated pressure overload-induced overexpression of metalloproteinase (MMP)-2, MMP-9 and MMP-13 in WT mice but not in TRPV1 KO mice. Capsaicin also attenuated angiotensin II-induced proliferation of cardiac fibroblasts from mice with the TRPV1 channel. CONCLUSIONS Our results suggest that dietary capsaicin protects against cardiac hypertrophy and fibrosis in pressure overload mice through TRPV1.
Helper Data Aware Cloning Method for Physical Unclonable Function

With the increase in the instances of damage caused by counterfeits of electronic components, a Physical Unclonable Function (PUF) has attracted attention as a technique to prevent counterfeiting. PUF uses arbitrary dispersion as specific identification, which is generated during semiconductor manufacturing. Even if all LSI circuit patterns are copied, PUF can discriminate the LSI circuit from counterfeits. However, the vulnerability of PUF to machine learning attacks has been reported. Although machine learning attacks can predict responses to unknown challenges with high probability, these attacks cannot completely predict responses. For machine learning attacks, the present study proposed a method to clone PUF's responses using error correction techniques, such as Fuzzy Extractor. The present study also demonstrated that the proposed method could clone PUF mathematically. An evaluation experiment revealed that in machine learning attacks, when the number of learning times was 1,024, the ratio of an arbiter PUF with 64 selector steps to predict responses was 95% and that of the proposed method was 100%. Therefore, the proposed method could clone responses completely.
Closed head injury in children.

ow naded rom http:urnals.lw w om /pe-online by hD M fePH bH 4TIm qVAH xkFJpPk1L/H vM G w qM xG jw O deJPG +b4D lKuA44qu/vw zm c= on 079/2018 Downloadedfromhttp://journals.lww. com/pec-onlinebyBhDMf5ePHKbH4TTImqenVAHxkFJp/XpPk1L/H3vMGwqMxG9jwOd8eJPG+b4DlKuAX44qu/vwzmc=on07/29/2018 0749-5161/02/1801-0048 Vol. 18, No. 1 PEDIATRIC EMERGENCY CARE Printed in U.S.A. Copyright © 2002 by Lippincott Williams & Wilkins, Inc.
The spatial integration effect of surface electrode detecting myoelectric signal

The spectral properties of surface electrodes used for myoelectric signal detection were investigated using both a theoretical and an experimental approach. On the basis of the theoretical model, the single surface electrode was found to act as a low pass filter depending on the electrode diameter (d) and the fiber conduction velocities (CVs). Several dips in the power spectrum were also predicted for varying frequencies depending on d and CV. The mathematical expression of the surface electrode filter was highly consistent with previously demonstrated properties of the single fiber power spectrum. An experimental comparison between myoelectric signals from the vastus lateralis muscle recorded using two electrode pairs with different diameters confirmed this low pass filter effect. However, the dip phenomenon was not observed from experimental data. The practical consequences of the electrode filter effect are discussed with respect to the interpretation of changes in surface myoelectric signal spectrum, particularly when a shift toward the high frequencies is observed. <<ETX>>
Precursor T-Cell Lymphoblastic Lymphoma Presenting as Cardiac Tamponade in a 25-Year-Old Male: A Case Report and Review of Literature

Precursor T-cell lymphoblastic lymphoma (LBL) and T-cell acute lymphoblastic leukemia (ALL) are considered same disease with different clinical presentations. Clinically, a case is defined as lymphoma if there is a mass lesion in the mediastinum or elsewhere and < 25% blasts in the bone marrow. Whereas, bone marrow with > 25% blasts with or without mediastinal masses is classified as T-cell ALL. Mediastinal masses caused by T-cell LBL can lead to complications such as superior vena cava syndrome, tracheal obstruction, pericardial effusion and tamponade. We report an unusual case of a 25-year-old male with no significant past medical history, who presented with clinical features of cardiac tamponade. Work-up revealed a massive pericardial effusion and a mass arising in the anterosuperior mediastinum. Patient underwent an emergent subxiphoid pericardial window and approximately 1 L of hemopericardium was drained. Histopathology (pericardial tissue) and flow cytometry on the pericardial fluid were compatible with a precursor T-cell LBL. Although pericardial involvement by lymphoma/leukemia is a very rare complication, cases have been reported with both lymphoma and acute/chronic leukemia. Our paper highlights cardiac tamponade as one of the life-threatening complications associated with a precursor T-cell LBL.
An integrative test strategy for cancer hazard identification

Abstract Assessment of genotoxic and carcinogenic potential is considered one of the basic requirements when evaluating possible human health risks associated with exposure to chemicals. Test strategies currently in place focus primarily on identifying genotoxic potential due to the strong association between the accumulation of genetic damage and cancer. Using genotoxicity assays to predict carcinogenic potential has the significant drawback that risks from non-genotoxic carcinogens remain largely undetected unless carcinogenicity studies are performed. Furthermore, test systems already developed to reduce animal use are not easily accepted and implemented by either industries or regulators. This manuscript reviews the test methods for cancer hazard identification that have been adopted by the regulatory authorities, and discusses the most promising alternative methods that have been developed to date. Based on these findings, a generally applicable tiered test strategy is proposed that can be considered capable of detecting both genotoxic as well as non-genotoxic carcinogens and will improve understanding of the underlying mode of action. Finally, strengths and weaknesses of this new integrative test strategy for cancer hazard identification are presented.
The Global Cold War: Third World Interventions and the Making of Our Times

Orne Westad, Professor of International History and Director of the Cold War Studies Centre at the London School of Economics, has hitherto been best known for his works on China and the Cold War, including Cold War and Revolution: Soviet-American Rivalry and the Origins of the Chinese Civil War, 1944–6 (New York, 1993) and Decisive Encounters: the Chinese Civil War, 1946–50 (Stanford, 2003). But he has taught the module on Third World interventions at LSE for some years as he has built up material for the current book, and some of his research in this area has already appeared in shorter works, such 'Moscow and the Angolan Crisis, 1974–76' in the Cold War International History Project Bulletin, 8–9 (Winter 1996–7) or 'Prelude to Intervention: the Soviet Union and the Afghan Communists, 1978–9', in the International History Review, 16.1 (1994). Those two article titles reflect one of the author's great strengths: his ability to analyse specific historical events in detail, using the latest document releases from the former Eastern bloc, challenging received opinion in the process. In this book-length work he is able to expand upon those detailed case studies but also to look beyond them and draw much wider conclusions about the nature of the Cold War in the so-called 'Third World'. It is a term Westad is happier to use than some other authors because it suggests, like the term 'third estate' in pre-revolutionary France, a group determined to assert itself and find justice. He defines the Third World as 'the former colonial or semi-colonial countries in Africa, Asia and Latin America that were subject to European . economic or political domination' (p. 3).
Aspect based opinion mining on restaurant reviews

Nowadays, expansion of social media and internet are driving to a whole another level. Most of the users critically review anything on the internet specially foods and services in restaurants to showcase their humble opinion. These opinions are very valuable in decision making process. Analyzing and extracting the actual opinion throughout these reviews manually is practically difficult since there are large numbers of reviews available in the various aspects. So, an automated methodology is needed to solve this problem. Opinion mining or sentiment analysis is such methodology to analysis these reviews and classify topics as positive, negative and neutral. There are three different levels of opinion mining; Document based, Sentence based and Aspect based. Document and Sentence based opinion mining focus on overall polarity of document and sentence respectively and do not describe the important aspects of each opinions which is more accurate. Hence Aspect based opining mining is the trending topic and this paper is specifically focused on it on reviews in the domain of restaurants.
The SMuSh pathway is essential for survival during growth-induced compressive mechanical stress

Cells that proliferate in a confined environment eventually build up mechanical compressive stress. For example, mechanical pressure can emerge from the growth of cancer cells or microbes in their natural settings. However, while the biological effects of tensile stress have been extensively studied, little is known about how cells sense and respond to mechanical compression. By combining genetic analysis with microfluidic approaches, we discovered that compressive stress is sensed through a module consisting of the mucin Msb2 and Sho1, which is one of the two osmosensing pathways in budding yeast. This signal is transmitted via the MAP kinase Ste11 to the cell wall integrity pathway. We term this mechanosensitive pathway the SMuSh pathway, for Ste11 through Mucin / Sho1 pathway. The SMuSh pathway is necessary for G1 arrest and cell survival in response to growth-induced pressure. Our study demonstrates the ability of budding yeast to specifically respond to mechanical compressive stress raising the question of whether homologous pathways confer mechano-sensitivity in higher eukaryotes.
Imaging , Diagnosis , Prognosis In Situ Tumor PD-L 1 mRNA Expression Is Associated with Increased TILs and Better Outcome in Breast Carcinomas

Purpose:Blockadeof the PD-1/PD-L1 axis emerged as apromising new therapeutic option for cancer that has resulted in lasting responses in metastatic renal, lung carcinomas, and melanomas. Tumor PD-L1 protein expression may predict response to drugs targeting this pathway. Measurement of PD-L1 protein is limitedby the lackof standardized immunohistochemicalmethods andvariable performanceof antibodies. Our goal was to correlate PD-L1 mRNA expression with clinical variables in primary breast carcinomas. Experimental Design: The fluorescent RNAscope paired-primer assay was used to quantify in situ PD-L1 mRNA levels in 636 stage I–III breast carcinomas on two sets of tissuemicroarrays [YTMA128 (n1⁄4 238) and YTMA201 (n1⁄4 398)]. Tumor-infiltrating lymphocytes (TIL) were assessed by hematoxylin/eosin stain and quantitative fluorescence. Results: On YTMA128 and YTMA201, 55.7% and 59.5% of cases showed PD-L1 mRNA expression, respectively. Higher PD-L1mRNA expressionwas significantly associatedwith increased TILs (P1⁄4 0.04) but notwith other clinical variables. Elevated TILs (scores 2 and3þ) occurred in 16.5%onYTMA128 and14.8% on YTMA201 andwas associated with estrogen receptor–negative status (P1⁄4 0.01 on YTMA128 and 0.0001 on YTMA201). PD-L1 mRNA expression was associated with longer recurrence-free survival (log-rank P 1⁄4 0.01), which remained significant inmultivariate analysis including age, tumor size, histologic grade, nodal metastasis, hormone receptor, HER2 status, and the extent of TILs (HR, 0.268; CI, 0.099–0.721; P1⁄4 0.009). Conclusions: PD-L1 mRNA expression is identified in nearly 60% of breast tumors and it is associated with increasedTILs and improved recurrence-free survival. These observations support the evaluation of PD1/PD-L1–targeted therapies in breast cancer. Clin Cancer Res; 20(10); 1–10. 2014 AACR.
Transform domain adaptive compressive sensing of specific objects

We have previously shown in reference [3] that images of particular objects of interest can be recovered from compressive measurements by minimizing a L2-norm criterion that incorporates prior knowledge of the signal such as its expected spectra. The basis in which the signal is reconstructed was also noted to be an important consideration in the formulation of the solution. In this paper, we further improve this technique by representing the image in a multi-scale domain so that select bands of the transform can be adapted to reference signals from other sources, while improving the overall quality of reconstruction of the full image. It is shown by means of an example that the adaptation not only reduces the overall mean square error of the reconstruction, but also helps to correctly resolve features in the high-resolution image that are not accurately reconstructed by the open-loop algorithm.
Designing Collaborative Learning Environments Using Educational Scenarios Based on SR

As more and more studies acknowledge that students are basic contributors to the learning process, factors such as self concept, (computer) self-efficacy and self-regulation are important in enhancing human performance. Nevertheless, these learner characteristics have received little attention in the e-learning environment. This paper presents the results of a study indicating significant positive relationships between learner characteristics, such as self-concept (academic achievement and job achievement), Computer Self Efficacy (CSE) and Self-Regulation (SR) constructs. Acknowledging the requirement for a strong shift of students towards developing self-regulated scenarios and strategies, we suggest that collaborative e-learning environments should be designed according to the self-regulated theory and self-beliefs. As a result, in this study we present a model examining how we can design educational scenarios based on self-regulation theory in a collaborative e-learning environment. This model is a tool for conducting experiments in e-learning university courses, studying the design, development and evaluation of the collaborative learning process.
The After-Effects of Ventriloquism

Subjects were tested for both ear-hand and eye-hand co-ordination before and after monitoring a synchronous series of noise bursts and of light flashes coming from the same spatial position, but with the virtual position of the flashes displaced 15° laterally by prisms. Attention was forced on both stimuli by the instruction to detect occasional reductions in intensity. No subject reported noticing the spatial discrepancy. Nevertheless ear—hand co-ordination was shifted in the direction of the prismatic displacement, and eye-hand co-ordination in the opposite direction. Both shifts were observed with instructions suggesting that the sound and the light came from one single source, with instructions suggesting two separate sources, and also with no information regarding the spatial relationship of sound and light. It is concluded that the resolution of auditory-visual spatial conflict involves recalibrations of both visual and auditory data and that these alterations last long enough to be detected as after-effects.
Study of the cytotoxic effect of new transition metals complexes : Cobalt ( II ) and Cadmium ( II ) on cancer cell line ( Hep 2 ) comparison with two anticancer drugs

The present study involved the cytotoxic effect of cobalt complex with formula [CoL(H2O)NO3]. 4ETOH where L= Nitro [5-(P-nitro phenyl)-4-phenyl-1,2,4-traizole -3dithiocarbamato hydrazide] aqua cobalt (II). Ethanol (4) and cadmium complex with formula [CdL2]. 1/2 H2O where L= Bis [5-(P-nitro phenyl) – 4phenyl -1,2,4traizole -3dithiocarbamato hydrazide] cadmium (II) hydrate (0.5) on the growth of heaptocellulare carcinoma (Hep2) cell line by using in vitro system comparison with two anticancer drugs (Cyclophosphamide and Cisplatin ) as appositive control. The cancer cell line were treated with different concentrations for each two complexes depending on concentrations of positive control after 48 hour exposur time. Our data reveals the highest of inhibition rate was reached to 38.49% and 34.65% for each cobalt (II) and cadmium (II) complexes at 1000μg/200μL comparison with cyclophosphamide. There were no significant differences between two complexes at two concentrations (500 and 1000) μg/ 200 μL . The results indicate the highest rate of inhibition level was 35.73% of cadmium complex and 29.65% of cobalt complex at 125μg/200μL comparison with anticancer drug Cis-platin. The mean value of decreasing percentage of cobalt (II) complex was reached to( – 7)% and cadmium (II) complex was reached to( – 15)% at the same concentration.
Survival on dialysis post-kidney transplant failure: results from the Scientific Registry of Transplant Recipients.

BACKGROUND A substantial number of patients return to dialysis therapy after a renal transplant fails. It is not clear whether mortality increases among patients with graft failure relative to those on the waiting list who have not yet received a kidney transplant. METHODS Data from the Scientific Registry of Transplant Recipients were analyzed (N = 175,436). Cox regression with time-dependent covariates was used to compare mortality between post-graft failure dialysis patients and primary transplant candidates on dialysis therapy. Mortality hazard ratios (HRs) were adjusted for age, sex, race, cause of end-stage renal disease, pre-waiting list time on dialysis therapy, calendar year of wait-listing, and organ procurement organization. RESULTS Overall, the post-graft failure dialysis group experienced a significant 78% greater mortality (HR, 1.78; P < 0.0001) relative to the transplant candidate group. The post-graft failure dialysis/transplant candidate HR was relatively constant across age groups, but significantly greater (P < 0.0001) among patients with diabetes (HR, 1.93) than among those without diabetes (HR, 1.69). The HR was greatest during the first week after graft failure (HR, 13.6; P < 0.0001) and decreased steadily thereafter. However, despite leveling off, the HR remained significantly elevated well after graft failure, including the 5- to 10-year period after graft failure. CONCLUSION Based on national data, mortality among patients on dialysis therapy after primary graft failure increases significantly relative to mortality among patients still awaiting primary kidney transplantation. Additional studies are urgently needed to define the mechanism of the increased risk and strategies to decrease mortality.