Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Dipeptidyl Peptidase-4 Inhibitors or Curcumin on Diet Induced Metabolic Syndrome with Cardiac Dysfunction in Rats

Background: Metabolic syndrome (MS) increases the risk of developing cardiovascular diseases (CVDs) which are the leading cause of death worldwide. Objective: This study is aiming to investigate the curative effects of dipeptidyl peptidase-4 inhibitors and the prophylactic effects of curcumin on diet induced metabolic syndrome which is associated with cardiac dysfunction in rats. Methodology: sixty adult male albino rats were divided into six groups: Group I: (control). Group II: (MS induced). Group III: (Vildagliptin only). Group IV: (Curcumin only). Group V (therapeutic): Vildagliptin treated rats after 8 weeks of MS to the end of 12 weeks. Group VI (prophylactic): Curcumin is administered with MS induction concomitantly for 12 weeks. Transthoracic echocardiogram was done while rats were alive. At the end of the experiment, blood was collected and biochemical analysis (blood glucose, serum insulin, lipid profile and cardiac enzymes) was done. Heart tissues were used for oxidative stress parameters (cardiac mitochondrial reactive oxygen species (ROS) and cardiac mitochondrial complex I and complex II) beside histopathological examination. Results: High fat diet (HFD) administration resulted in a significant increase in blood glucose, serum insulin, homeostasis model assessment of IR (HOMAIR) index with disturbed lipid profile. Significant increase in serum cardiac enzymes and oxidative stress tissue markers were also noticed. Echocardiography revealed structural and functional cardiomyopathy. Histopathological examination showed cellular infiltrations with fat cells and collagen fibers accumulation. DPP4 inhibitors and curcumin resulted in a significant decrease in glucose, insulin, and HOMAIR index, partial amelioration of lipid profile, cardiac enzymes, and cardiac oxidative stress markers. Echocardiography revealed alleviation of cardiomyopathy. Histopathological examination also revealed highly manifested structural improvement. Conclusion: The current study revealed that both DPP4 inhibitors and curcumin improve cardiomyopathy resulted from HFD administration with a diversity of mechanisms including anti-inflammatory, anti-apoptotic and anti-oxidative ways. JRAM 2021; 2(1): 93-103
Influence of blood metabolites and body condition score at parturition on fertility and milk yield in Holstein cows

Background: Variables associated with body tissue mobilization place dairy cows at greater risk of reproductive failure. Objective: To investigate the association between blood metabolites and body condition score (BCS) at the beginning of lactation and the reproductive efficiency and milk yield of Holstein cows in a hot environment. Methods: In total, 165 Holstein cows were selected for the study from which blood samples were taken to determine the concentration of various blood metabolites and their association with the reproductive efficiency and milk yield. Results: Cows with serum β-hydroxybutyrate (BHBA) ≤0.8 mmol/L one week postpartum were 3.3 times more likely to become pregnant at first service, and 2.2 times more likely to become pregnant before 80 d postpartum than cows with higher serum BHBA levels. The odds (OR 2.7; 95% CI 1.3–5.4; p<0.01) of a cow getting pregnant at first service were higher in cows with serum creatinine levels higher than 2.0 mg/dL
La alimentación en producción intensiva de animales monogástricos: Un elemento clave para reducir su impacto ambiental

Animal nutrition is a key factor in guaranteeing the sustainability of livestock farming, especially in the intensive production of monogastrics. The environmental impact of this sector is mainly related to the production of feedstuffs and manure management. Feed ingredients determine the environmental footprint of feeds. Under our conditions, soy replacement with local protein sources and an increase in the use of by-products could, initially, improve the sustainability of feeds. However, in order to assess
Short-term exposure of PM2.5 and PM10 increases the number of outpatients with eczema in Guangzhou: A time-series study

Background The worldwide prevalence of eczema has continued to rise over the past decades. This has led to the emphasis on the association between air pollution and eczema. This study investigated the relationship between daily exposure to air pollution and the number of eczema outpatient visits in Guangzhou with the overarching goal of providing novel insights on the interventions for eczema aggravation and prevention. Methods Daily air pollution data, meteorological data, and the number of eczema outpatients were obtained from 18 January 2013 to 31 December 2018 in Guangzhou. A generalized additive model with Poisson distribution was used to assess the association between the number of eczema outpatient visits and short-term exposure to PM2.5 and PM10. In addition, the association of PM2.5 and PM10 by age (<65 years, ≥65 years) and gender was evaluated. Results A total of 293,343 eczema outpatient visits were recorded. The obtained results indicated that a 10 μg/m3 increase of the same day/lag 1 day/lag 2 days PM2.5 was associated with increments of 2.33%, 1.81%, and 0.95% in eczema outpatient risk, respectively. On the other hand, a 10 μg/m3 increase of PM10 was associated with eczema outpatients risk increments of 1.97%, 1.65%, and 0.98% respectively. Furthermore, the associations of PM on the increment of eczema were similar in the male and female groups. Results obtained after age stratified analyses indicated that the strongest positive association between PM2.5 exposure and eczema was observed at lag 0 day with the percent changes being 4.72% and 3.34% in <12 years old, ≥12 and <65 years old, and ≥65 years old groups, respectively. Conclusion Short-term exposure to PM2.5 and PM10 increases the number of eczema outpatients, especially among children and the elderly. The relationship between air quality trends and hospital resource arrangement should be paid attention to by hospital managers which may aid in disease prevention and lower the health burden.
Radial Pulse Wave Analysis in Young Male Elite Athletes

Background: Indicators obtained from the analysis of the radial pulse wave allow an indirect evaluation of the interaction between cardiac ejection and arterial walls. Objectives: To analyze the characteristics of the arterial pulse in young elite athletes through a cross-sectional observational study. Methods: We evaluated the radial pulse wave in 35 high performance young male athletes, who practice various sports, comparing them with 36 healthy men of similar ages, using the applanation tonometry technique. We computed conventional indicators of central increase in central pressure and aortic propagation velocity, and added two new indicators: the slope of the increase in radial pressure and the amplitude of the oscillatory component during diastole. Results: In relation to controls, athletes exhibited lower heart rate (61.6 ± 9.1 vs. 71.4 ± 10.6 bpm, p < 0.001), lower pulse wave velocity (7.0 ± 1.0 vs. 7.5 ± 0.8 m/s, p < 0.001), lower diastolic blood pressure (67.6 ± 8.2 vs. 78.5 ± 7.3 mmHg, p < 0.001) and higher brachial pulse pressure (53.6 ± 8.3 vs. 46.7 ± 7.1 mmHg, p < 0.001). The systolic slope (0.70 ± 0.15 vs. 0.59 ± 0.13 mmHg/ms, p < 0.001) and the amplitude of diastolic oscillation (25.7 ± 6.4 vs. 18.4 ± 4.7%, p < 0.001) were significantly higher in athletes than in controls. Conclusion: Young athlete presented low aortic velocity, but significantly higher systolic slope and diastolic oscillation amplitude than controls. The steeper systolic slope and the lower diastolic blood pressure could underlie a higher
Short forms of the Wechsler adult scales: a systematic review

Introduction. Since the appearance of the first WAIS scale, there has been a widespread attempt by researchers in the assessment of cognitive abilities to find short forms that facilitate the clinical practice of professionals in those situations where conditions, either because of the time available or the clinical characteristics of patients, do not necessitate the use of an extensive tool. Objective. To carry out a systematic review of the short forms of up to four subtests extracted from the WAIS-III and WAIS-IV scales. Method. Search for information in the PsycINFO database and systematic review of the information following the PRISMA guidelines. Results. Of the 47 studies found, 36 were selected for full-text revision, of which 13 were finally included in this review: 6 of the WAIS-III and 7 of the WAIS-IV. Different forms achieved good results in the quality criteria established in a variety of samples. Discussion and conclusion. There are several forms that are useful for estimating the IQ, according to the samples and the quality criteria used.
The Kinetic Model for Decolourization of Commercial Direct Blue 2 Azo Dye Aqueous Solution by the Fenton Process and the Effect of Inorganic Salts

The study of Fenton’s oxidation and degradation of Direct Blue 2 (DB2) as the commercial azo dye in synthetic aqueous solution has been accomplished. The optimum oxidative degradation reaction conditions were achieved as follows: pH = 3.50, [H2O2] = 1.1×10 -3 M, [Fe2+] = 1.0×10-4 M for [DB 2] = 1.0×10-4 M. Under optimal conditions, 80% of decolouration efficiency was carried out within 15 min of reaction. An engagement between the kinetics of the colour removal rates (ln k2) versus Lazo bond was carried out at the different pH levels. The colour removal rate was increased with decreasing of Lazo bond, in the order of pH: 3.5 > 5.0 > 2.5. The second-order kinetic model provided the best correlation of the data. Effects of various inorganic anions (such as Cl–, SO4 2-, CO3 2-, etc.) was studied to enhance the oxidation efficiency of Fenton reaction. Advanced oxidation technologies were developed in this study especially with dealing with contaminated textile wastewater over the use of chemical treatment.
Outlier percentage estimation for shape- and parameter-independent outlier detection

: Accurate and robust three-dimensional reconstruction of objects allows for applications in many aspects of modern life. Yet, it typically suffers from outliers and noise which often need to be post-processed. Although many algorithms are able to effectively remove the outliers, most require a certain amount of manual tuning of the parameter(s) or to have a parameter(s) set based on the rule of thumb. New machine learning and artificial intelligence-based methods have also been introduced but may require vast parallel computing resources as well as training data. In the present study, a novel combinatory-distance-based method capable of high accuracy outlier detection named as the sorted distance divergence point (SDDP) is introduced. Results show that SDDP is able to achieve an average accuracy of 98% in outlier detection. Moreover, the introduced distance function and outlier percentage allow clear labelling of inliers and outliers cloud points. Therefore, SDDP presents an attractive enhancement to existing methods; namely, the manual parameter(s) tuning may not be necessary. The adaptability and utility of SDDP is further demonstrated by incorporating SDDP with current methods, to produce a high accuracy outlier detector. When tested with 17 objects with 20–50% outliers, attain F 1 and F 2 scores averaging 0.960 and 0.968, respectively.
The Effects of the Electrode Type on Microstructure and Hardness of the RSW of DP600 Steel

In this paper, the effects of the electrode type on microstructure and hardness of the resistance spot welded junctions of DP steel were studied. Commercial galvanized DP sheet steel was used. Resistance spot welding (RSW), with changing electrode type according to geometry, has been carried out with constant weld time, weld current and weld pressure. Microstructure and hardness are depending on materials properties and weld parameter particularly heat input. Heat input is resulted from welding condition and parameters. Electrode tip type effects welding contact and heat transfer during RSW. Results showed that particularly spherical type electrode showed low heat input thus limited microstructure changing at heat affected zone. This have on positive effect on properties of the junctions. Depending on chemical composition of DP 600 harder phases generally formed at weld zone.
Structure and properties of CaTiO3

A new determination of the atomic structure of CaTiOa has been made. It is orthorhombic, with space group _Pcmn; atomic coordinates are given. Synthetic crystals are identical with the majority of natural perovskite specimens. Two of the modes of twinning reported by Bowman from optical analysis have been confirmed by both X-ray and optical methods. With increasing temperature in the range --200 ° C. to 900 ° C. changes in cell dimensions are such as to approximate more closely to those characteristic of higher symmetry, but the substance is still orthorhombic at 900 ° C.
Effect of nitrogen–oxygen complex on electrical properties of Czochralski silicon

Effect of nitrogen–oxygen (N–O) complexes on electrical properties of nitrogen‐rich Czochralski (CZ) silicon grown in a nitrogen atmosphere has been investigated during annealing in the temperature range from 650 to 1000 °C. Electrical and low temperature (8 K) Fourier transmission infrared spectrometer (FTIR) measurements point out that the carrier concentration of the nitrogen‐rich silicon varies with the annealing time and temperature, which is due to the formation and elimination of the N–O complexes acting as shallow thermal donors. After the N–O complexes are eliminated by annealing above 900 °C the carrier concentration of the nitrogen‐rich silicon is stabilized. It is suggested that the N–O complexes attract more oxygen atoms to form new electrically inactive N–O clusters, and lose their electrical activity.
Penalized logistic regression using functional connectivity as covariates with an application to mild cognitive impairment

There is an emerging interest in brain functional connectivity (FC) based on functional Magnetic Resonance Imaging in Alzheimer’s disease (AD) studies. The complex and high-dimensional structure of FC makes it challenging to explore the association between altered connectivity and AD susceptibility. We develop a pipeline to reﬁne FC as proper covariates in a penalized logistic regression model and classify normal and AD susceptible groups. Three di ﬀ erent quantiﬁcation methods are proposed for FC reﬁnement. One of the methods is dimension reduction based on common component analysis (CCA), which is employed to address the limitations of the other methods. We applied the proposed pipeline to the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data and deduced pathogenic FC biomarkers associated with AD susceptibility. The reﬁned FC biomarkers were related to brain regions for cognition, stimuli processing, and sensorimotor skills. We also demonstrated that a model using CCA performed better than others in terms of classiﬁcation performance and goodness-of-ﬁt.
Understanding congruence in person-centred counselling practice: A trainee counsellor’s perspective

Congruence is a condition in therapeutic relationship that refers to accurate matching of a person’s experience with awareness. In person-centred counselling, counsellor’s congruence is believed as one of helpful and significant aspects that facilitates clients’ growth in counselling. However, this term is quite difficult to understand as a single condition as it interrelated to the other conditions such as empathy and unconditional positive regard. Understanding congruence theoretically and practically is intriguing as well as challenging especially for a trainee counsellor that is still learning to apply theory on practice. This paper aims to critically explore congruence from person-centred counselling theory and to demonstrate some evidences of the development of congruence in practice based on the author’s counselling practice as a trainee counsellor. There are three main discussions in this paper that is to explain congruence from the theoretical point of view, to understand the relation between congruence and acceptance and to explore congruence in person-centred practice. The exploration found that trainee counsellor’s cultural background including condition of worth and language barrier is one of challenges in experiencing congruence within person-centred counselling practice.Keywords: congruence, person-centred counselling, unconditional positive regard, ontological standpoint
An Evaluation of VGG16 Binary Classifier Deep Neural Network for Noise and Blur Corrupted Images

Deep learning networks has become an important tool for image classification applications. Distortions on images may cause the performance of a classifier to decrease significantly. In the present paper, a comparative investigation for binary classification performance of VGG16 network under corrupted inputs has been presented. For this purpose, images corrupted at various levels and fixed levels with Gaussian noise, Salt and Pepper noise and blur effect were used for testing. Convolutional layers of the VGG16 were frozen except the last three convolutional layers and a dense layer for binary classification was added. According to experimental results, as the effect of distortion is increased, performance of the deep learning classifier drops significantly. In the case of augmented training with distortion effects, the results were improved significantly
Synchrotron Mössbauer spectroscopic study of ferropericlase at high pressures and temperatures

Abstract The electronic spin state of Fe2+ in ferropericlase, (Mg0.75Fe0.25)O, transitions from a high-spin (spin unpaired) to low-spin (spin paired) state within the Earth’s mid-lower mantle region. To better understand the local electronic environment of high-spin Fe2+ ions in ferropericlase near the transition, we obtained synchrotron Mössbauer spectra (SMS) of (Mg0.75,Fe0.25)O in externally heated and laser-heated diamond anvil cells at relevant high pressures and temperatures. Results show that the quadrupole splitting (QS) of the dominant high-spin Fe2+ site decreases with increasing temperature at static high pressure. The QS values at constant pressure are fitted to a temperature-dependent Boltzmann distribution model, which permits estimation of the crystal-field splitting energy (Δ3) between the dxy and dxz or dzy orbitals of the t2g states in a distorted octahedral Fe2+ site. The derived Δ3 increases from approximately 36 meV at 1 GPa to 95 meV at 40 GPa, revealing that both high pressure and high temperature have significant effects on the 3d electronic shells of Fe2+ in ferropericlase. The SMS spectra collected from the laser-heated diamond cells within the time window of 146 ns also indicate that QS significantly decreases at very high temperatures. A larger splitting of the energy levels at high temperatures and pressures should broaden the spin crossover in ferropericlase because the degeneracy of energy levels is partially lifted. Our results provide information on the hyperfine parameters and crystal-field splitting energy of high-spin Fe2+ in ferropericlase at high pressures and temperatures, relevant to the electronic structure of iron in oxides in the deep lower mantle.
Syndiotactic Polystyrene / Fullerene Composites: Elucidation of Structural Aspect

Summary:Syndiotacticpolystyrene(sPS),anattractivepolymerduetoitswiderangeof application, forms polymer-solvent intercalates with a large variety of solventmolecules ranging from liquids to solids. Recently, it has been realized that sPSintercalate prepared from SPS/naphthalene gel is more promising of making meso-porous materials. Here, the composite of sPS/fullerene have been prepared by takingadvantage of sublimation of naphthalene. The different techniques as like XRD, SEM,HRTEM, FT-IR, DSC, TGA etc have been employed to characterized sPS/fullerenecomposite. XRD investigation shows the presence of d form sPS in the composite.SEM and HRTEM reveal the ﬁbrillar network with fringe like structure in presence offullerene only and the average diameter of ﬁbril has increased as compared to puresPS ﬁbrils. The conductivities of these ﬁbrils have been increased with increasingamount of fullerene. Keywords: conductivity; fullerenes; nano ﬁber; polymer-solvent complex; syndiotacticpolystyrene
Erkennen fetaler Wachstumsretardierung – das GAP-Programm als neues Tool in der hebammengeleiteten Schwangerenvorsorge

Das in England entwickelte Growth Assessment Protocol (GAP) unterstützt die Erkennung fetaler Wachstumsretardierung und konnte in britischen Studien die Totgeburtenrate deutlich senken. Für Hebammen ist das GAP-Programm ein zuverlässiges Instrument, um das fetale Wachstum zu beurteilen und Auffälligkeiten sicher zu identifizieren. Die Autorin des vorliegenden Artikels ist Ansprechpartnerin für GAP in Deutschland und setzt sich dafür ein, die Umsetzung des Programms für deutschsprachige Hebammen zu erleichtern.
Integration and Synchronization of Population Policies Through Grand Design Population Development in Indonesia

The problem of population in Indonesia is complex. Population policy in the era of decentralization is still notintegrated and sustainable. Grand Design of Population Development is a guideline for population-orientedpolicies, strategies and development programs, which contains important current population issues, desiredpopulation conditions, population development programs, population development roadmaps coveringpopulation quantity control, quality development population, family development, spatial planning andpopulation regulation and population administration development. Approach Grand Design of PopulationDevelopment can influencing policy and responsive policy towards population dynamics. With the GrandDesign of Population Development, a region can prepare itself to welcome the demographic bonus that canbe done through improving human quality. Human development as an effort to develop capability the abilityof human self, which contains four elements, namely productivity, equity, sustainability and empowerment.The roadmap set out in Grand Design of Population Development will be implemented on an ongoing basisto improve human quality, reflected in the increasing Human Development Index.
High genetic diversity among diarrheagenic Escherichia coli isolates from patients with acute diarrhea in Khuzestan province, Southwestern Iran

Background: Diarrheagenic Escherichia coli (DEC) is an enteric pathogen that causes a wide variety of gastrointestinal diseases in developing countries. In our previous study, the prevalence of DEC pathotypes from acute diarrhea patients in Khuzestan province was determined. In this study, we investigated the antimicrobial resistance profile and molecular genetic characteristics of this isolate. Methods: Antibiotic susceptibility testing of bacterial isolates was determined by disc diffusion technique on Muller Hinton agar. The production of extended-spectrum beta-lactamases (ESBLs) was confirmed by the Double Disc Synergy Test (DDST). The genetic diversity of isolates was determinate by pulsed-field gel electrophoresis (PFGE). Results: Among all DEC strains, 100% were resistant to at least one commonly prescribed antibiotic. Strains were resistant to first-line antibiotics, such as tetracycline, ampicillin, and sulfamethoxazole-trimethoprim. Furthermore, 72% of DEC isolates were multidrug-resistant and aEPEC and STEC were the categories with a major proportion of this feature. ESBL-producing strains were observed in 38% of all DEC isolates. PFGE analysis showed 19 unique pulsotypes of 22 studied DEC pathotypes. However, a few isolates were found to be clonal (clusters A, B, and C). Conclusion: The current study provides novel information about the presence of DEC isolates particularly with the rate of high antibiotic resistance among acute diarrheal samples in Khuzestan, Iran. Our data revealed that there was almost high heterogeneity among isolated DEC pathotypes. Proper infection control policies are needed to be implemented in order for the infections to be effectively controlled.