Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel case of dup(3q) syndrome due to a de novo interstitial duplication 3q24‐q26.31 with minimal overlap to the dup(3q) critical region

Dup(3q) syndrome is characterized by typical facial features, mental and growth retardation, often with congenital heart defects. The syndrome has attracted special attention because of the clinical overlap with Cornelia de Lange syndrome (CDLS). Patients with dup(3q) syndrome are trisomic for segments of the long arm of chromosome 3, most often within the region 3q21 to 3qter. Most cases have arisen as unbalanced translocations and do involve other chromosomes also. A dup(3q) minimal region has been defined at 3q26.3‐q27. We report here a 15‐month‐old boy with a de novo interstitial inverted duplication of 3q24‐q26.31. Clinical evaluation revealed mild but typical features of dup(3q) syndrome. The duplication was characterized by conventional and molecular cytogenetics. The results allow further narrowing of the dup(3q) critical region at its distal end and suggest the existence of one or several major genes responsible for the dup(3q) syndrome in the proximal half of 3q26.31. Moreover, the results of fluorescence in situ hybridization (FISH) analysis with BAC probes suggest a disruption of the NLGN1 gene at the distal end of the duplication in 3q26.31 in the patient. The breakpoint within NLGN1 is unique for this patient, and the contribution of NLGN1 disruption to the phenotype of this patient remains unclear. Yet since NLGN1 is involved in synaptogenesis in the central nervous system, altered gene dosage is a good candidate for mental retardation as a recurrent feature of dup(3q) syndrome. © 2004 Wiley‐Liss, Inc.
Strategic Trade Policy With Domestic Cost Asymmetries

In this paper we examine optimal strategic trade p[olicy under oligopoly with many home and foreign firms when the firms have different levels of efficiency and where a trade-off exists between the subsidy bill and firms profits. The first-best policy involves a structure of firm specific export subsidies and export taxes in which the government favours the most efficient firms unless the social cost of funds is sufficiently high. Whenoptimal policy is constrained to a uniform subsidy the optimal policy depends on the relative number of home and foreign firms and the curvature of demnand. Deficiencies of the uniform subsidies are examined.
Manufacturability demonstration of an integrated SiGe HBT technology for the analog and wireless marketplace

Early production results are reviewed for IBM's integrated SiGe HBT technology. With a sample size of over 200 wafers, statistical control of key HBT parameters (F/sub T/, F/sub max/, R/sub bb/, R/sub bi/, /spl beta/) and other supporting devices, and benchmark circuit performance are shown. HBT device yield and reliability on 200 mm wafers are presented, demonstrating that the SiGe HBT is capable of meeting manufacturing requirement for the high performance wireless communications marketplace.
Dissociable temporal effects of bupropion on behavioural measures of emotional and reward processing in depression

Antidepressants remediate negative biases in emotional processing early in treatment, prior to mood improvement. However, the effects on reward processing potentially relevant to the treatment of anhedonia are less clear. Here we investigate the early and sustained effects of the dopamine and noradrenaline reuptake inhibitor bupropion on behavioural measures of emotional and reward processing in currently depressed individuals. Forty-six currently depressed patients and 42 healthy controls participated in a repeated measures study, during which open-label bupropion was administered to only the patient group over a six week period without a placebo group. All participants completed the Emotional Test Battery and a probabilistic instrumental learning task at week 0, week 2 and week 6. Currently depressed patients displayed negative biases in emotional processing and blunted response bias for high-probability wins compared to the healthy controls at baseline. Bupropion was found to reduce the negative biases in emotional processing early in treatment, including a significant decrease in the percentage misclassification of other face emotions as sad and the number of negative self-referent words falsely recalled between baseline and week 2. Conversely, bupropion was found to initially further reduce the response bias for high-probability wins between baseline and week 2. This effect reversed with six weeks' bupropion treatment and reward processing was normalized compared to the healthy controls. Early in treatment, bupropion acts to reduce negative biases in emotional processing but exacerbates impaired reward processing. The beneficial actions of bupropion on reward processing then occur later in treatment. Such dissociation in the temporal effects of bupropion on emotional and reward processing has implications for the treatment of the different symptom domains of negative affect and anhedonia in depression. This article is part of a discussion meeting issue ‘Of mice and mental health: facilitating dialogue between basic and clinical neuroscientists’.
Ethical perspectives on relations between industry and neuropsychiatric medicine

Conflicts of interest may influence medical research. In particular, the study on psychotropic treatment of ageing subjects suffering from neurological disorders and comorbid neuropsychiatric phenomena may be hypothetically considered economically non-advantageous, or even of negative impact on drug reputation, because of the high probability of non-response or side effects. Thus, studies on this issue may be disregarded from industry. We aimed to verify whether the global commitment of medical research reflects the actual relevance of depression in the world ageing population, associated or not with neurological conditions. Here, we: 1) have reviewed the literature on this issue, 2) have examined world published data concerning population by age, burden of disease and frequency of depressive disorders and antidepressant therapies, and 3) have reviewed the frequency of published papers on depression and its treatment associated with three neurological conditions. The overall rate of papers about depressive disorders in ageing people reflects adequately the world population and the prevalence of depression in the elderly. However, the rate of papers concerning medical experimentation for antidepressant treatment in Alzheimer's disease, Parkinson's disease and stroke is quite inadequate with respect to the rate of depressive disorders associated to these conditions. Thus, innovative medical experimentation must be encouraged, also in areas apparently of dubious economical advantage but of undoubted clinical relevance and the adoption of strategies to limit the detrimental effect of conflicts of interest in research must be enhanced.
“Design and implementation of OFDM based cognitive radio system and its analysis”

In the wireless communication field we are dealing with new emerging technologies and applications. Due to large no. of applications we are scarcity of radio spectrum. Thus, spectrum utilization is very important issue nowadays. In order to utilize the radio spectrum and increase the efficiency of the wireless communication system we need to design a compact system. The purpose of our project is to design an OFDM based cognitive radio system and analyze the performance of the system in terms various channel parameter over different fading channels. Initially we are have designed and implemented this system and then by setting different channel environment as well as system parameters we have observed efficiency of the system in terms of bit error rate and other parameters. By varying system parameters and setting the different channel environment we can observe the behavior of the system.
The yeast GAL4 protein transactivates the polyomavirus origin of DNA replication in mouse cells

We have replaced the polyomavirus (Py) enhancer, which is an essential component of the Py origin of DNA replication (ori), with five repeats of a 17-bp oligonucleotide including the yeast GAL4 upstream activating sequence (5xGAL4 sites). Plasmids containing this modified Py ori, designated test plasmids, and plasmids encoding either the GAL4 transcriptional activator protein or various derivatives of this protein were cotransfected into mouse cells which constitutively synthesize a temperature-sensitive Py large tumor antigen (T-Ag). Replication of the test plasmids was monitored by Southern blot determinations of the amounts of plasmid DNA that became resistant to cleavage by the enzyme DpnI. These studies showed that in the presence of a functional T-Ag, the GAL4 protein, and hybrid proteins including the GAL4 DNA-binding domain and the activating domain of the adenovirus E1a or herpesvirus VP16 protein transactivated the modified Py ori. A truncated protein including just the GAL4 DNA-binding domain was inactive in these assays. The authentic GAL4 protein was found to be a more efficient replication transactivator than the hybrid proteins. In contrast, chloramphenicol acetyltransferase assays showed that the hybrid proteins were more efficient transcriptional activators than the GAL4 protein. The extent of the GAL4-dependent replication of a plasmid in which the Py early promoter was deleted was 55% lower than that of a plasmid including the promoter. However, the extents of replication of plasmids including two tandem repeats of the remaining Py origin core and 5xGAL4 sites or two origin cores flanking a single cluster of 5xGAL4 sites were 4.8- and 1.6-fold higher than that of the plasmid including a single copy of each element. The replication of a plasmid including two clusters of 5xGAL4 sites flanking a single origin core was below the limit of detection of our assays. These results indicate that the GAL4 and hybrid transactivators do not activate the Py ori by virtue of their interactions with transcription factors that bind promoter elements. Rather, it appears that these activator proteins may interact with the replication initiation complexes, thereby facilitating or inhibiting the initiation of replication.
Decomposing Aggregate Trade Flows: New Evidence from U.S. Traders

Using firm-level data on export transactions, we uncover a rich set of results about the extensive margins of exporting and exporter responses during periods of global downturns. We perform our analysis with respect to firm size, age, ownership status, and sector to emphasize the role of firm heterogeneity. We uncover a larger role for firm entry and exit in changes in annual export flows of single-unit, smaller, and younger firms. Young, small firms perform best during both periods of crises as well as non-crises periods. We also decompose the margins of U.S. imports at the U.S. importer, foreign supplier, and U.S. importer-foreign supplier pair levels. While export flows are closely correlated with global business cycles, import flows more closely approximate U.S. economic cycles. Additionally, both pair and foreign supplier flows are far more volatile than U.S. import flows, that is, U.S. importer-foreign supplier matches experience more churning on average than do either U.S. importers or foreign suppliers.
Boundary Value Problem for Caputo-hadamard Fractional Differential Equations

The aim of this work is to study the existence and uniqueness solutions for boundary value problem of nonlinear fractional differential equations with Caputo-Hadamard derivative in bounded domain. We used the standard and Krasnoselskii’s fixed point theorems. Some new results of existence and uniqueness solutions for Caputo-Hadamard fractional equations are obtained.
Understanding the financial crisis : investment, risk and governance

List of Figures and Tables Foreword L.B. Falkenberg Introduction: Macroeconomic Perspectives on the Financial Crisis: An Overview O.Risager PART I: REGULATION AND RISK MANAGEMENT Overview: Regulation and Risk Governance C.Rose The Credit Crisis of 2007 and its Implications for Risk Management J.Hull Some Thoughts on the Role of Mathematical Models in Light of the Crisis D.Lando Enterprise Architectures for Investment Managers from a Risk Management Perspective M.Schroter PART II: REGULATION AND GOVERNANCE Overview: Corporate Governance and the Financial Crisis S.Thomsen Avoiding International Financial Crises: An Incomplete Reform Agenda J.Dermine Reputational Risk and the Financial Crisis I.Walter Governance and the Financial Crisis R.Adams Governance, Risk and Compliance in the Financial Sector: An IT Perspective in Light of the Recent Financial Crisis K.J.Nordgard PART III: IN PRACTICE Three Executive Interviews: Evidence from the Front Line of Investment Management C.Rose
L'après projet ERP : Retour d'expérience sur un changement qui n'a pas eu lieu

The aim of this article is to present a few concrete examples of the consequences of a non scheduled change in ERP implementations. In the post-ERP phase, we provide a socio-economic assessment of those consequences by looking at the following factors: technology, behavior of the players, organization, project management. When the ERP software has become operational but the expected results are still missing, does the post-ERP phase consist in a new project or does it require a different approach? Such is the question that this article attempts to answer.
Nasal lavage cellularity, grain dust, and airflow obstruction.

To evaluate the clinical utility of nasal lavage (NL), we performed post-work shift NL on 172 grain workers and 78 postal worker control subjects. The grain worker group included a higher percentage of current smokers (25.7% vs 16.7%) and a lower percentage of former smokers (21.15% vs 35.9%) compared with the postal workers. The control subjects included more female workers and were slightly older than the grain workers. Compared with the postal workers, the grain workers were exposed to significantly greater concentrations of total dust (0.1 +/- 0.0 vs 6.8 +/- 1.4 mg/m3; mean +/- SEM) and total endotoxin (4.3 +/- 0.8 vs 2,372.4 +/- 653.8 endotoxin units/m3). NL from gain workers showed a higher concentration of total cells (55,000 +/- 14,000 vs 25,000 +/- 5,000 cells per milliliter; p=0.03), a higher concentration of squamous epithelial cells (17,029.0 +/- 4,177 .0 vs 7,103.7 +/- 1,479.8 cells per milliliter; p=0.03), and a higher concentration of neutrophils (40,058.0 +/- 12,803.2 vs 17,891.0 +/- 3,822.3 cells per milliliter; p=0.10) compared with postal workers. Importantly, these differences in NL cellularity between grain workers and postal workers were observed within the three strata of smokers. To further assess the importance of total cells, squamous epithelial cells, and neutrophils in the NL fluid of grain workers, we investigated the relationship between these cell concentrations and (1) measures of dust and endotoxin exposure during the work shift. (2) spirometric measures of airflow obtained immediately before the NL, and (3) work-related respiratory symptoms. The concentration of total cells, the concentration of squamous epithelial cells, or the concentration of neutrophils in the NL was not associated with ambient levels of dust or endotoxin, with baseline or cross-shift changes in lung function, or with work-related respiratory symptoms. These findings suggest that increased NL cellularity may be seen in workers exposed to high dust levels. However, the NL cellularity does not appear to be associated with ambient concentrations of dusts or endotoxins, with signs of airflow obstruction, or with work-related respiratory symptoms.
Mesenchymal stem cells for cartilage regeneration in osteoarthritis

Osteoarthritis (OA) is a slowly progressive disease where cartilage of the synovial joint degenerates. It is most common in the elderly where patients experience pain and reduce physical activity. In combination with lack of conventional treatment, patients are often left with no other choices than arthroplasty. Over the last years, multipotent stromal cells have been used in efforts to treat OA. Mesenchymal stem/progenitor cells (MSCs) are stromal cells that can differentiate into bone, fat, and cartilage cells. They reside within bone marrow and fat. MSCs can also be found in synovial joints where they affect the progression of OA. They can be isolated and proliferated in an incubator before being applied in clinical trials. When it comes to treatment, emphasis has hitherto been on autologous MSCs, but allogenic cells from healthy donors are emerging as another source of the cells. The first adaptations of MSCs revolved in the use of cell-rich matrix, delivered as invasive surgical procedure, which resulted in production of hyaline cartilage and fibrocartilage. However, the demand for less invasive delivery of cells has prompted the use of direct intra-articular injections, wherein a large amount of suspended cells are implanted in the cartilage defect.
A prospective randomized study of sternal closure: comparison of Mersilene tape versus standard wire closure.

BACKGROUND To compare in a prospective randomized study Mersilene tape and standard metal wire for complications and pain upon sternal wound closure. METHODS Sixty-four patients scheduled for cardiac surgery were prospectively randomized to undergo sternal closure using either Mersilene tape (n=30) or standard metal wire (n=34). The intensity of postoperative pain from the chest wound was assessed using a visual analogue scale (VAS) on the second and seventh postoperative days and one month after surgery. The examinations with chest X-ray and computed tomography (CT) one month after surgery were performed to evaluate the chest wound and sternum. Follow-up data on sternal and wound healing was assessed for up to one year. RESULTS No deaths, sternal dehiscence or infection occurred in either group. No wound complications were observed in either group during the year following surgery. A review of data revealed that there was no difference in the intensity of postoperative pain according to the VAS between the two groups. Chest CT demonstrated that no patients in either group had cuts in the sternum. CONCLUSION This prospective randomized study showed Mersilene tape sternal closure not to be more closely associated with increased complications or patient discomfort due to sternal wound than the standard wire closure.
Beyond retrovirus infection : HIV meets gene therapy

The human immunodeficiency virus (HIV) is classified as a retrovirus because of its RNA genome and the fact that it requires reverse transcriptase to convert it into DNA. This virus belongs to the lentivirinae subfamily and is able to infect quiescent cells but is better known for its association with acquired immunodeficiency syndrome (AIDS) and can be described as one of the most effective vectors for gene transfer. Biosafety concerns are present whenever viral vectors are employed but are particularly pertinent to the development of HIV-based vectors. Insertional mutagenesis and the production of new replication-competent viruses (RCV) have been pointed to as major problems, but experimental data have shown that safe protocols can be developed for their production and application. Virological, evolutionary, immunological and cell biology studies must be conducted jointly to allow the clinical use of HIV vectors. This review will focus on the general properties, production and applications of retrovectors in gene therapy, with particular emphasis on those based on HIV systems.
ECONOMIC ASPECTS OF RESIDENTIAL RENTAL REAL ESTATE: A COMPARISON OF GERMANY, THE NETHERLANDS, AND THE USA

The residential rental real estate market is subject to several types of regulation. Their economic impact is generally thought to be substantial; however their perceived benefits are controversial. This study tries to shed new light on the perceived impact by comparing the regulation of the residential real estate market in Germany, the Netherlands, and the United States, something that has not been done before in the literature. Employing a neo-classical analysis the authors evaluate the experience and outcomes of two particular types of regulation, namely Rent Control and Housing Quality Standards, in these three countries. Based on this analysis, it becomes possible to make recommendations with regards to the usefulness of these types of regulation, given the differences in each country.
Overcoming Culture Shock: Journal reflection

From Syria via Turkey and Greece to ultimately Ireland, it has been a very long journey full of ups and downs, tears of frustration and dismay, the odd glimmer of hope. Eleven months on roads and cross country, living in tents and the odd night under a proper roof, it was a long and tortuous road that finally took me and 129 other Syrians to Dublin. It was December 2016 when we landed at Dublin airport, cheerful and hopeful and greatly relieved. It was the beginning of the honeymoon phase in Ireland as new arrivals - or at least it was for me. [. ]
Internet Financial Reporting By Commercial Banks in Nigeria

The paper investigates the level of internet usage and content of financial information on the websites of Nigerian banks. Thirteen (13) banks were randomly selected as samples (out of the 25 ‘mega’ banks that survived the 2006 consolidation exercise) and their websites visited to collect information. The result of the study reveals that all the sampled banks have websites and that majority of them posted financial information on their websites.
The Dimensions of Customer Satisfaction of Aavin Milk in Hyderabad, India

It is a well known fact that the term 'Customer satisfaction' is widely used in all aspects of marketing which is pivotal to any company to measure the level or height of satisfaction of the consumers of a specific product or service. The researcher of this paper upon a thorough study have understood that this measure or dimension would be an indicator of consumer intentions on repeated purchase with loyalty, differentiation of products or services and to retain the customers under focus. The researcher thus conducted the research on the Dimensions of Customer Satisfaction of Aavin Milk in Hyderabad, India. To measure the satisfaction levels the researher has taken care while conducting this research.
The Emerging Significance of Total Reward Management as a Strategy for Building Employee Engagement

This research note explores the growing significance of employee engagement to effective organisational performance. In doing this, arguments from a range of areas of HR, including Strategic Human Resource Management, Employee Engagement, Human Capital Management and Strategic Reward Management, are drawn together. As a result of this analysis a more broad-based view of reward is proposed which can build employee engagement and thus contribute to enhanced organisational performance. Suggestions are made for research to test the proposed model and the research note concludes with a review of the practical implications of the total reward strategy proposed.
Non-Motorized Transportation – An Educational Challenge For Urban Communities

The continuous growth of the urban traffic threats cities with “thrombosis“, generating social, economic and ecological long term problems. The paper outlines the positive externalities induced by the non-motorized transportation (walking, bicycling or small-wheeled transport) at individual, social and environmental level. This kind of transportation meets the requests of the urban sustainable development, being used stand-alone or as a part of an intermodal chain. Local authorities, education institutes, corporate and non-governmental organizations should be involved in challenging perceptions and attitudes toward non-motorized trips. Beside the infrastructure construction, the early education is mandatory for creating a civic culture regarding the use of non-motorized transportation. The case study in Bucharest shows out the present state concerning the use of non-motorized transportation and the barriers in using it.