Miracle-dz/UniFAR-FTUs huggingface dataset:
Shearwaters know the direction and distance home but fail to encode intervening obstacles after free-ranging foraging trips

Significance Procellariiform seabirds homing from distant foraging locations present a natural situation in which the homing route can become obstructed by islands or peninsulas because birds will not travel long distances over land. By measuring initial orientation from Global Positioning System (GPS) tracks during homing, we found that the Manx shearwater fails to encode such obstacles while homing, implying a navigation system that encodes the direction of home rather than a learned route. Nonetheless, shearwaters timed their journeys home, implying that their navigational system provides them with information about both direction and distance home, providing evidence that for routine, yet long-distance navigation, seabirds probably ascertain homeward direction by comparing their current position and the location of home with 2 or more intersecting field gradients. While displacement experiments have been powerful for determining the sensory basis of homing navigation in birds, they have left unresolved important cognitive aspects of navigation such as what birds know about their location relative to home and the anticipated route. Here, we analyze the free-ranging Global Positioning System (GPS) tracks of a large sample (n = 707) of Manx shearwater, Puffinus puffinus, foraging trips to investigate, from a cognitive perspective, what a wild, pelagic seabird knows as it begins to home naturally. By exploiting a kind of natural experimental contrast (journeys with or without intervening obstacles) we first show that, at the start of homing, sometimes hundreds of kilometers from the colony, shearwaters are well oriented in the homeward direction, but often fail to encode intervening barriers over which they will not fly (islands or peninsulas), constrained to flying farther as a result. Second, shearwaters time their homing journeys, leaving earlier in the day when they have farther to go, and this ability to judge distance home also apparently ignores intervening obstacles. Thus, at the start of homing, shearwaters appear to be making navigational decisions using both geographic direction and distance to the goal. Since we find no decrease in orientation accuracy with trip length, duration, or tortuosity, path integration mechanisms cannot account for these findings. Instead, our results imply that a navigational mechanism used to direct natural large-scale movements in wild pelagic seabirds has map-like properties and is probably based on large-scale gradients.
Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids

It is common to find abundant genetic variation in host resistance and parasite infectivity within populations, with the outcome of infection frequently depending on genotype-specific interactions. Underlying these effects are complex immune defenses that are under the control of both host and parasite genes. We have found extensive variation in Drosophila melanogaster’s immune response against the parasitoid wasp Leptopilina boulardi. Some aspects of the immune response, such as phenoloxidase activity, are predominantly affected by the host genotype. Some, such as upregulation of the complement-like protein Tep1, are controlled by the parasite genotype. Others, like the differentiation of immune cells called lamellocytes, depend on the specific combination of host and parasite genotypes. These observations illustrate how the outcome of infection depends on independent genetic effects on different aspects of host immunity. As parasite-killing results from the concerted action of different components of the immune response, these observations provide a physiological mechanism to generate phenomena like epistasis and genotype-interactions that underlie models of coevolution.
Anti‐inflammatory effects of eriocitrin against the dextran sulfate sodium–induced experimental colitis in murine model

Inflammatory bowel disease (IBD) is a continual ailment condition which engrosses the entire alimentary canal. The IBD can be primarily distinguished into two forms, ulcerative colitis, and Crohn's disease. The major symptoms of IBD include pustules or abscesses, severe abdominal pain, diarrhea, fistula, and stenosis, which may directly affect the patient's quality of life. A variety of mediators can stimulate the circumstances of IBD, some examples include infections by microbes such as bacteria, perturbation of the immune system and the surrounding environment of the intestines. Severe colitis was stimulated in the experimental animals through administering 4% dextran sulfate sodium (DSS) which is mixed in water ad libitum for 6 days. Eriocitrin (30 mg/kg) was then administered to the experimental animals followed by the induction of severe colitis to evaluate the therapeutic prospective of eriocitrin against the colon inflammation stimulated by DSS. In this study, eriocitrin (30 mg/kg) demonstrated significant (P < .05) attenuation activity against the DSS‐stimulated severe colitis in experimental animals. Eriocitrin counteracted all of the clinical deleterious effects induced by DSS, such as body‐weight loss, colon shortening, histopathological injury, accretion of infiltrated inflammatory cells at the inflamed region and the secretion of inflammatory cytokines. The results clearly showed that eriocitrin effectively attenuated DSS‐induced acute colitis in experimental animals.
Neuroengineering and neuroprosthetics

This article contains a directed overview of the field of neuroengineering and neuroprosthetics. The aim of the article is, however, not to go over introductory material covered elsewhere, but rather to look ahead at exciting areas for likely future development. The BrainGate implant is focussed on in terms of its use as an interface between the Internet and the human nervous system. Sensory prosthetics of different types and deep brain stimulation are considered. Different possibilities with deep brain stimulation are also discussed.
Diversity scaling of human vaginal microbial communities

The composition and diversity of the human vaginal microbial community have been investigated intensively due to the diversity-stability relationship (DSR)-based hypothesis for bacterial vaginosis (BV) etiology, which was first proposed in the 1990s and has received renewed interest in recent years. Nevertheless, diversity changes (scaling) across individuals in a cohort or population have not yet been addressed, which is significant both theoretically and practically. Theoretically, biodiversity scaling is the core of biogeography, and practically, inter-subject heterogeneity is critical for understanding the etiology and epidemiology of human microbiome-associated diseases such as BV. Here we applied the diversity-area relationship (DAR), a recent extension to the classic species-area relationship (SAR), to study diversity scaling of the vaginal microbiome by reanalyzing reported data collected from 1 107 postpartum women. The model used here characterized the power-law (or its extension) relationships between accrued diversity and areas (numbers of individuals), upon which four biogeographic profiles were thus defined. Specifically, we established the DAR profile (relationship between diversity scaling parameter and so-termed diversity order (q)), similarly pair-wise diversity overlap (PDO) profile, maximal accrual diversity (MAD) profile, and ratio of individual-level to population-level diversity (RIP) profile. These four profiles offer valuable tools to assess and predict diversity scaling (changes) in the human vaginal microbiome across individuals, as well as to understand the dynamics of vaginal microbiomes in healthy women.
Letter to the Editor: Bilateral Femoroacetabular Impingement: What is the Fate of the Asymptomatic Hip?

To the Editor, I read the study by Azboy and colleagues [1] with great interest. In their study, the authors addressed the prognosis of the asymptomatic hip in patients with bilateral radiographic signs of femoroacetabular impingement (FAI) and unilateral symptomatic FAI. I believe it is worth examining their study’s patient inclusion criteria. My concern is that patients with developmental dysplasia of the hip (DDH) were included in their study (25 of 74 patients). The definition of DDH was not shown in the paper, but a patient with lateral center-edge angle of 11° was included, and this made me wonder whether at least some of these patients were experiencing symptoms from DDH rather than FAI. They stated that of the 74 patients including DDH, 60 patients became symptomatic, and most of them underwent subsequent surgical intervention on the contralateral hip. If some of these patients may have had DDH in addition to radiographic FAI, it may be difficult or impossible to attribute the hip pain to FAI, rather than to instability from DDH. The pathomechanism that causes hip damage in DDH are completely different from the mechanism that causes hip injury in FAI [5]. In DDH, the unstable femoral head migrates and subluxates in regions where the femoral head is least covered, while in FAI, the femoral head remains wellcentered, but the free arc of hip motion is limited by either a prominent acetabular margin (pincer type), a misshapen proximal femur (cam type), or a combination of the two (mixed type) [5]. This suggests that as long as DDH is present, hip symptoms are likely to be caused by hip instability, even if concomitant cam deformity is present [7]. It is notable that cam deformity was occasionally found in patients with DDH who underwent periacetabular osteotomy (22%); however, none of them had symptoms of FAI [3]. A systematic review also demonstrated that patients with lateral center-edge angle of < 25° should not be considered to have FAI to differentiate other pathologies such as hip instability [8]. In my view, patients with DDH should be considered separately when examining FAI unless impingement is clearly demonstrated by some kind of objective methods like kinematic analysis. Azboy and colleagues [1] do not recommend any particular intervention for the patients who developed hip pain in the asymptomatic hip; however, evidence suggests that we should be skeptical of isolated arthroscopic FAI procedures that do not address the underlying DDH [2, 4, 6]. Since pelvic osteotomy is needed to definitively treat the pathoanatomy of DDH, we should question whether isolated arthroscopic treatments are effective over a long period for patients with DDH.
Melatonin and corticosterone profiles under polar day in a seabird with sexually-opposite activity-rhythms

A prime example of plant–animal interactions is the interaction between plants and pollinators, which typically receive nectar and/or pollen as reward for their pollination service. While nectar provides mostly carbohydrates, pollen represents the main source of protein and lipids for many pollinators. However, the main function of pollen is to carry nutrients for pollen tube growth and thus fertilization. It is unclear whether pollinator attraction exerts a sufficiently strong selective pressure to alter the nutritional profile of pollen, e.g., through increasing its crude protein content or protein-to-lipid ratio, which both strongly affect bee foraging. Pollen nutritional quality may also be merely determined by phylogenetic relatedness, with pollen of closely related plants showing similar nutritional profiles due to shared biosynthetic pathways or floral morphologies. Here, we present a meta-analysis of studies on pollen nutrients to test whether differences in pollen nutrient contents and ratios correlated with plant insect pollinator dependence and/or phylogenetic relatedness. We hypothesized that if pollen nutritional content was affected by pollinator attraction, it should be different (e.g., higher) in highly pollinator-dependent plants, independent of phylogenetic relatedness. We found that crude protein and the protein-to-lipid ratio in pollen strongly correlated with phylogeny. Moreover, pollen protein content was higher in plants depending mostly or exclusively on insect pollination. Pollen nutritional quality thus correlated with both phylogenetic relatedness and pollinator dependency, indicating that, besides producing pollen with sufficient nutrients for reproduction, the nutrient profile of zoophilous plants may have been shaped by their pollinators’ nutritional needs.
Leveraging the Facebook ads platform for election polling

Election polls provide valuable insights about voting intention on candidates filtered by demographic characteristics. This information can be used to understand the dynamics of underlying electoral preferences and how it changes in the days or months during the campaign. Despite its importance, election polls are time and money consuming on many occasions. Especially those with face-to-face surveys, that interview a representative population of the voters across the entire country. In this study, we propose a novel approach that explores social media advertising platforms to infer the audience demographics of politicians in the electoral race. We leverage the attribute-based targeting available on the Facebook Advertising platform by using the 'interests' related to candidates to calculate their audience demographics. Then, we compared the online extracted data with election polls taken in the same period. Our findings suggest that the candidate's popularity on Facebook, captured in terms of the number of likes, people talking about him/her, and the number of people interested in the candidate, is a valid indicator of his/her variation on vote intention polls. Additionally, we figured out that the fluctuation in the demographic aspects of supporters detected by election polls are captured by our methodology, obtaining more precision with popular candidates. In particular, we show that sharp variations occasioned by high impact events during the campaign such as protests are well captured by Facebook measurements. Finally, we deployed a system that exposes the audience demographics of Brazilian politicians on Facebook (available at http://www.audiencia-dos-politicos.dcc.ufmg.br/) and contributes to the understanding of the political scene in Brazil.
Attitudes, knowledge, and willingness to be vaccinated against seasonal influenza among patients hospitalized with influenza-like-illness: impact of diagnostic testing

ABSTRACT Influenza vaccine adherence remains low. Communication of virological diagnosis to adults hospitalized with influenza-like illness (ILI) could improve their willingness to be subsequently vaccinated. We prospectively assessed, in adults hospitalized with ILI in six French university hospitals, their willingness to be vaccinated against influenza in the subsequent season, both before and after the communication of RT-PCR Influenza laboratory result; we identified then the determinants associated with the willingness to be vaccinated. A total of 309 patients were included during the 2012–2013 and 2013–2014 influenza seasons; 43.8% reported being vaccinated against influenza for the current season; before communication of influenza laboratory results, 65.1% reported willingness to be vaccinated during the subsequent season. Influenza was virologically confirmed in 103 patients (33.3%). The rate of vaccine willingness increased to 70.4% (p = .02) after communication of influenza laboratory results. Factors independently associated with the willingness to be vaccinated were the perception of influenza vaccine benefits (adjusted relative risk (aRR): 1.06, 95%CI 1.02–1.10), cues to action (aRR: 1.08, 95%CI 1.03–1.12), current season influenza vaccination (aRR: 1.38, 95%CI 1.20–1.59) and communication of a positive influenza laboratory result (aRR: 1.18, 95%CI 1.03–1.34). This last was associated with the willingness to be vaccinated only in the subpopulation of patients not vaccinated (aRR: 1.53, 95%CI 1.19–1.96). In patients hospitalized with ILI, communication of a positive influenza diagnostic led to a better appreciation of the disease’s severity and increased the willingness to be vaccinated. This approach might be particularly beneficial in patients who do not have a history of influenza vaccination.
Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer

The role of radiotherapy (RT) in the treatment of patients with anaplastic thyroid cancer (ATC) for local tumor control is critical because mortality often is secondary to complications of tumor volume rather than metastatic disease. Herein, the authors report the long‐term outcomes of RT for patients with ATC.
Simulating the Effect of Adaptivity on Randomization

This paper compares the development of multi-chaotic system during the optimization process on three classical benchmark functions – Rosenbrock, Rastrigin and Ackley. The multi-chaotic system involves five different randomizations based on discrete chaotic maps (Burgers, Delayed Logistic, Dissipative, Lozi and Tinkerbell) and the probability of their selection is adjusted according to the development of the optimization task. Two variants of Differential Evolution (DE) are used in order to simulate the effect of adaptivity on the randomization probability adjustment process. First non-adaptive variant is DE with rand/1 mutation strategy and the second adaptive variant is novel Success-History based Adaptive DE (SHADE).
Thermochromic nail polish as a novel indicator to predict infraclavicular brachial plexus block success: A prospective cohort study.

BACKGROUND Skin temperature measurements after peripheral nerve block can be used as an easy and objective method to help predict block success. Thermochromic nail polishes are popular cosmetic products especially among young women. The colour change of nail polish is based on a thermochromic reaction as the temperature changes. OBJECTIVE The aim of this study was to test the hypothesis that the success of infraclavicular brachial plexus blocks (IBPBs) can be predicted by the colour change in thermochromic nail polish, which depends on skin temperature changes. DESIGN A prospective cohort study. SETTING Training and research hospital from December 2018 to March 2019. PATIENTS A total of 50 patients who received IBPB for forearm, wrist or hand surgery were included. MAIN OUTCOME MEASURES Thermochromic nail polish was applied to the nails of both hands of all patients before the block. Reaction of the nail polish in both hands was photographed immediately after application of nail polish and at 30 min after performing the block. The digital photographs of each patient were evaluated by observers. To evaluate the validity of the colour change in nail polish in predicting a successful IBPB, sensitivity, specificity, positive and negative predictive values and positive and negative likelihood ratios were estimated. RESULTS The positive predictive value for colour change in thermochromic nail polish predicting a successful IBPB was 96% [95% confidence interval (CI) 90 to 98] and sensitivity was 94% (95% CI 87 to 97). Fleiss kappa value showed substantial agreement (0.76; 95% CI 0.59 to 0.93) in the assessment of interobserver agreement. CONCLUSION The current study demonstrates that the colour change in thermochromic nail polish is a valid and reliable indicator for the prediction of block success. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT03767868.
Systematic review of determinants influencing knowledge implementation in occupational therapy.

INTRODUCTION In knowledge translation, implementation strategies are more effective in fostering practice change. When using these strategies, however, many determinants, such as individual or organisational factors, influence implementation. Currently, there is a lack of synthesis concerning how these determinants influence knowledge implementation (KI). The aim of this systematic review was to document how determinants influence KI outcomes with occupational therapists. METHOD Following the PRISMA statement, we systematically reviewed the literature on KI in occupational therapy across 12 databases: MEDLINE, Embase, CINAHL, AMED, PsychINFO, Cochrane Library, FirstSearch, Web of Science, ProQuest Dissertations & Theses, ERIC, Education Source and Sociological Abstracts. Eligible studies reported KI strategies specifically with occupational therapists. Selected studies were appraised for quality with the Mixed Methods Appraisal Tool. Using the Consolidated Framework for Implementation Research (CFIR), we categorised reported mentions of CFIR (sub-)constructs to identify the determinants studied most often, how they were documented and what influence they had on outcomes. RESULTS Twenty-two studies were analysed for this review. CFIR (sub-)constructs were mentioned 81 times, and seven (sub-)constructs received at least 5% of these mentions (4/81). These were as follows: (i) Adaptability of the practice; (ii) Learning climate; (iii) Leadership engagement; (iv) Available resources; (v) Knowledge and Beliefs about the Intervention; (vi) Individual Stage of Change; and vii) Executing the KI strategy. The Inner setting domain was the most documented and the domain with the most (sub-)constructs with at least four mentions (3/7). Most studies used questionnaires as assessment tools, but these were mainly non-standardised scales. The data were too heterogenous to perform a meta-analysis. CONCLUSION Seven (sub-)constructs mentioned most often would benefit from being assessed for salience by researchers intending to develop a KI strategy for occupational therapists. Future research aimed at improving our understanding of KI should also consider using standardised tools to measure the influence of determinants.
An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation

ABSTRACT Ricin toxin, a plant-derived, mannosylated glycoprotein, elicits an incapacitating and potentially lethal inflammatory response in the airways following inhalation. Uptake of ricin by alveolar macrophages (AM) and other pulmonary cell types occurs via two parallel pathways: one mediated by ricin’s B subunit (RTB), a galactose-specific lectin, and one mediated by the mannose receptor (MR;CD206). Ricin’s A subunit (RTA) is a ribosome-inactivating protein that triggers apoptosis in mammalian cells. It was recently reported that a single monoclonal antibody (MAb), PB10, directed against an immunodominant epitope on RTA and administered intravenously, was able to rescue Rhesus macaques from lethal aerosol dose of ricin. In this study, we now demonstrate in mice that the effectiveness PB10 is significantly improved when combined with a second MAb, SylH3, against RTB. Mice treated with PB10 alone survived lethal-dose intranasal ricin challenge, but experienced significant weight loss, moderate pulmonary inflammation (e.g., elevated IL-1 and IL-6 levels, PMN influx), and apoptosis of lung macrophages. In contrast, mice treated with the PB10/SylH3 cocktail were essentially impervious to pulmonary ricin toxin exposure, as evidenced by no weight loss, no change in local IL-1 and IL-6 levels, retention of lung macrophages, and a significant dampening of PMN recruitment into the bronchoalveolar lavage (BAL) fluids. The PB10/SylH3 cocktail only marginally reduced ricin binding to target cells in the BAL, suggesting that the antibody mixture neutralizes ricin by interfering with one or more steps in the RTB- and MR-dependent uptake pathways.