Miracle-dz/UniFAR-FTUs huggingface dataset:
Designing Lifestyle Interventions for Common Mental Disorders: What Can We Learn from Diabetes Prevention Programs?

Lifestyle factors including diet, sleep, physical activity, and substance use cessation, are recognised as treatment targets for common mental disorders (CMDs). As the field of lifestyle-based mental health care evolves towards effectiveness trials and real-world translation, it is timely to consider how such innovations can be integrated into clinical practice. This paper discusses the utility and scale-up of lifestyle interventions for CMDs and draws on diabetes prevention literature to identify enablers and barriers to translation efforts. We discuss the extent to which lifestyle interventions aimed at managing CMDs and preventing diabetes share commonalities (program content, theoretical underpinnings, program structures, interventionists, frameworks promoting fidelity, quality, sustainability). Specific considerations when utilising these programs for mental health include personalising content with respect to symptoms and trajectories of depression and anxiety, medication regimen and genetic risk profile. As this field moves from efficacy to effectiveness and implementation, it is important to ensure issues in implementation science, including “voltage drop”, “program drift”, logistics, funding, and resourcing, are in line with evidence-based models that are effective in research settings. Ongoing considerations includes who is best placed to deliver this care and the need for models to support implementation including long-term financing, workforce training, supervision, stakeholder and organisational support.
State-Dependent Variations in the Expected Illiquidity Premium

Recent evidence on state-dependent variations in market liquidity suggests strong variations in the illiquidity premium across economic states. Adopting a two-state Markov switching model, we find that, while illiquid stocks are affected more by economic conditions than liquid ones are during recessions, the differences in expected returns are relatively small during expansions. Therefore, the expected illiquidity premium displays strong state-dependent variations that are countercyclical. We show that the state of a high illiquidity premium is closely associated with periods of real economic recessions, market declines, and high volatility, which coincides with major events of liquidity dry-up and high liquidity commonality.
Communities of Tweeple: How Communities Engage with Microblogging When Co-located

Most of the research done on microblogging services, such as Twitter, has focused on how the individual communicates with their community at a micro and macro level; less research has been done on how the community affects the individual. We present in this thesis some ideas about this phenomenon. We do this by collecting data of Twitter users at a conference. We collected 21,150 tweets from approximately 400 users during a five week period and additionally collected survey data from a small subset of the tweeters. By observing users of Twitter, before, during, after a specific event we discovered a pattern in postings. Specifically, we found that tweets increased the week of the conference and that by the end of the conference the network was strong. These findings lead us to conclude that collocation of communities, like conferences, has a substantial effect on online microblogging behaviors.
The Nexus between Work-Life Conflict and Job Satisfaction: Evidence from Network and System Integration Industry in Sri Lanka

Work life conflict is an inter role conflict that arises due to conflicting roles required by organization and from one’s family. Objective of this study is to investigate the impact of work life conflict on job satisfaction of employees in Network and System Integration industry in Sri Lanka. Data for the study was from 147 employees working in different Network and System Integration organizations of Sri Lanka using structured questionnaire. Correlation analysis was used to find the association between identified variables of the study. Findings revealed that job satisfaction is significantly negatively correlated with Family to Work interference and Stress. However, the correlation of Work to Family Interference and working hours are positive and insignificant which shows that these two variables does not affect the job satisfaction of the employees in Network and System Integration Industry. The findings of the study suggest that work family conflict and job satisfaction becomes an increasingly important concern for organizations when focusing on the issue of developing employees in the changing global and regional scenario. Information Technology organizations should come up with effective and efficient work – life balance policies and programs and foster an organizational culture that supports the use of available policies is also of great importance. This will help to reduce the work – life conflict for employees in Network and System Integration Industry.
Improving the User Story Agile Technique Using the INVEST Criteria

Although the Agile Software Development (ADS) approach has been around for the last 15 years, it is only recently that attention has moved towards Agile Software Management (ASM) for tackling some of the management-related weaknesses, such as estimating on the basis of User Story points. This paper presents an application of the INVEST criteria (Independent - Negotiable - Valuable - Estimable - Small -Testable) for improving the measurement technique of User Stories, introducing sizing units and a technique to negotiate requirements. It includes a discussion on an approach to balancing the six criteria used to evaluate a set of User Stories in a Sprint.
The development and impact of computer-tailored nutrition education

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Repeated Exercise Induces Release of Soluble P-Selectin in Patients with Intermittent Claudication

Summary Controversy exists as to whether exercise in patients with intermittent claudication causes a harmful biochemical effect associated with an ischaemia-reperfusion injury of skeletal muscle. We report on exercise-induced changes in neutrophil activation, soluble P-selectin and von Willebrand factor in 34 patients with intermittent claudication and 12 matched controls. Von Willebrand factor (vWF) showed a cyclical pattern of response to exercise in control subjects (rising from 103 ± 8 to 119 ± 7 U/dl); claudicants did not show this pattern but had higher levels of vWF throughout (p <0.03). There was no consistent pattern of response in neutrophil hydrogen peroxide production to exercise in either claudicants or control subjects. Soluble P-selectin levels increased after exercise, but this only reached statistical significance after repeated exercise in claudicants (rising from 320 ± 28 to 357 ± 28 ng/ml). This rise in soluble P-selectin after exercise may indicate progressive platelet activation which may contribute to the excess cardiovascular mortality that claudicants are prone to.
Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system

Reactivation of latent herpes simplex virus type 2 (HSV-2) by the immediate-early protein Vmw110 was studied by using an in vitro latency system. Adenovirus recombinants that express Vmw110 reactivated latent HSV-2. An HSV-1 mutant possessing a deletion in a carboxy-terminal region of Vmw110 reactivated latent HSV-2, whereas mutant FXE, which has a deletion in the second exon, did not. Therefore, Vmw110 alone is required to reactivate latent HSV-2 in vitro, and the region of Vmw110 defined by the deletion in FXE is important for this process.
Individual Investments in Education and Health: Policy Responses and Interactions

Abstract Empirical studies show that years of schooling are positively correlated with good health. The implication may go from education to health, from health to education, or from factors that influence both variables. We formalize a model that determines an individual’s demand for knowledge and health based on the causal effects, and study the impacts on the individual’s decisions of policy instruments such as subsidies on medical care, subsidizing schooling, income tax reduction, lump-sum transfers, and improving health at young age. Our results indicate that income redistribution policies may be the best instrument to improve welfare, while a medical care subsidy is the best instrument for longevity. Subsidies to medical care or education would require large imperfections in these markets to be more welfare improving than distributional policies.
Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway.

Effects of inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase (MEK/MAPK) cascade have been examined in relation to paclitaxel-induced apoptosis in human monocytic leukemia cells (U937). Cells treated with paclitaxel (250 nm; 6 h) followed by PD98059 [corrected] exhibited a significant increase in mitochondrial dysfunction (e.g., cytochrome c release), caspase activation, poly ADP-ribose polymerase cleavage, and apoptosis, whereas pretreatment of cells with PD98059 reduced lethality. Similar results were obtained with other MEK/MAPK inhibitors (e.g., U0126 and PD184352). Subsequent exposure of paclitaxel-treated cells to PD98059 did not enhance dephosphorylation/activation of p34(cdc2) but diminished expression of the antiapoptotic protein Mcl-1. The caspase inhibitor ZVAD-fmk opposed potentiation of paclitaxel-induced loss of mitochondrial membrane potential (Deltapsi(m)) and apoptosis by PD98059, but not cytochrome c release. Paclitaxel treatment induced sustained phosphorylation/activation of MAPK, an effect prevented by subsequent, but not prior, exposure to PD98059. Paclitaxel treatment also induced c-Jun N-terminal kinase phosphorylation, but this effect was enhanced only slightly by subsequent PD98059 administration. Although paclitaxel alone failed to induce p38 MAPK activation, subsequent (but not prior) exposure to PD98059 induced a dramatic increase in p38 MAPK phosphorylation. Moreover, coadministration of the p38 MAPK inhibitors SB203580 and SB202190 abrogated the increase in paclitaxel-mediated apoptosis induced by PD98059. Finally, subsequent PD98059 exposure increased, whereas prior exposure decreased inhibition of clonogenicity by paclitaxel. Together, these findings suggest that subsequent exposure of paclitaxel-treated U937 cells to MEK/MAPK inhibitors induces perturbations in signaling pathways, particularly the p42/44 MAPK and p38 MAPK cascades, that lower the threshold for mitochondrial injury and induction of cell death.
Infantile hypertrophic pyloric stenosis (IHPS): it can take away your breath, alertness, wee and poo

A 5-week old full-term previously healthy first-born male infant presented with apnoea, desaturations, increasing lethargy, anuria for 1 day and constipation for 5 days. This was on a background of persistent projectile non-bilious vomiting for 10 days, during which he had been given Carobel for presumed gastritis and gastro-oesophageal reflux. Father's cousin had pyloric stenosis. He was lethargic, pale and dehydrated with 14% weight loss. Heart rate was 130/min, shallow respirations of 28/min, intermittent desaturations to 70–80%. He had epigastric fullness with visible peristalsis. He was started on 36% oxygen, given two boluses of normal saline. Urine dipstick after resuscitation showed pH 7.0, venous blood gas showed pH 7.53, PCO2 9.2, PO2 3.21, HCO3 55 and BE 27.8. ECG showed flat T-waves and …
Functional near-infrared spectroscopy

The purpose of the this article is to describe an emerging neuroimaging technology, functional near-infrared spectroscopy (fNIRs), which has several attributes that make it possible to conduct neuroimaging studies of the cortex in clinical offices and under more realistic, ecologically valid parameters. fNIRs use near-infrared light to measure changes in the concentration of oxygenated and deoxygenated hemoglobin in the cortex. Although fNIR imaging is limited to the outer cortex, it provides neuroimaging that is safe, portable, and very affordable relative to other neuroimaging technologies. It is also relatively robust to movement artifacts and can readily be integrated with other technologies such as EEG
The Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Evaluation of Bone Lesions of Undetermined Origin

The aim of the current study was to determine the diagnostic accuracy of whole-body fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting carcinoma of unknown primary (CUP) with bone metastases. We evaluated 87 patients who were referred to FDG-PET/CT imaging and reported to have skeletal lesions with suspicion of malignancy. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated. The median survival rate was measured to evaluate the prognostic value of the FDG-PET/CT findings. In the search for a primary, FDG-PET/CT findings correctly diagnosed lesions as the site of the primary true positive (TP) in 64 (73%) cases, 4 (5%) findings diagnosed no site of a primary, and none were subsequently proven to be true negative (TN); 14 (16%) diagnoses were false positive (FP) and 5 (6%) diagnoses were false negative (FN). Life expectancy was between 2 months and 25 months. Whole-body FDG-PET/CT imaging may be a useful method in assessing the bone lesions with suspicion of bone metastases.
Planning strategies in volumetric modulated are therapy for breast.

PURPOSE In breast radiotherapy with intensity modulation, it is a well established practice to extend the dose fluence outside the limit of the body contour to account for small changes in size and position of the target and the rest of the tissues due to respiration or to possible oedema. A simple approach is not applicable with RapidArc volumetric modulated are therapy not being based on a fixed field fluence delivery. In this study, a viable technical strategy to account for this need is presented. METHODS RapidArc (RA) plans for six breast cancer patients (three right and three left cases), were optimized (PRO version III) on the original CT data set (0) and on an alternative CT (E) generated with an artificial expansion (and assignment of soft-tissue equivalent HU) of 10 mm of the body in the breast region and of the PTV contours toward the external direction. Final dose calculations for the two set of plans were performed on the same original CT data set O, normalizing the dose prescription (50 Gy) to the target mean. In this way, two treatment plans on the same CT set O for each patient were obtained: the no action plan (OO) and the alternative plan based on an expanded optimization (EO). Fixing MU, these two plans were then recomputed on the expanded CT data set and on an intermediate one (with expansion = 5 mm), to mimic, possible changes in size due to edema during treatment or residual displacements due to breathing not properly controlled. Aim of the study was to quantify the robustness of this planning strategy on dose distributions when either the OO or the EO strategies were adopted. For all the combinations, a DVH analysis of all involved structures is reported. RESULTS I. The two optimization approaches gave comparable dose distributions on the original CT data set. II. When plans were evaluated on the expanded CTs (mimicking the presence of edema), the EO approach showed improved target coverage if compared to OO: on CT_10 mm, Dv = 98% [%]= 92.5 +/- 0.9 and 68.5 +/- 3.1, respectively, for EO and OO. Minor changes were registered in organs at risk sparing for both EO and OO. III. From dose distributions and DVHs, EO approach allowed to irradiate at near to prescription levels also the expanded fraction of the target: this would account also for residual intrafraction movements. CONCLUSIONS The proposed plan strategy could represent a robust approach to account for moderate changes in target or body volume during the course of breast radiotherapy and to account for residual intrafractional respiratory motion in volumetric modulated are therapy. The strategy, logistically simple to implement requiring only modifications to the standard planning workflow was routinely implemented at author's institute for treatment of breast patients with RapidArc.
Grouping and Cooperating Among Access Points in User-Centric Ultra-Dense Networks With Non-Orthogonal Multiple Access

A user-centric ultra-dense network (UUDN) is proposed as one of the promising solutions to provide very high area throughput density and flexible access service for users in the fifth-generation systems. On the one hand, network densification provides opportunities to cooperate among a large number of access points (APs) for serving a given user. On the other hand, the limited radio resources cause the serious competition among numerous APs and may degrade the network performance. Therefore, to support large number of connections and break through the restriction of limited frequency resource, non-orthogonal multiple access (NOMA), which supports multiple signals to transmit on the same frequency resource, is introduced into the UUDN. However, NOMA with network densification arises a series of challenges. And the method to group APs efficiently on the same frequency to support for a given user is a critical problem. Thus, in this paper, we propose a user-centric access framework for providing efficient access service and the flexible resource management in NOMA-based UUDN. Under the proposed framework, we then investigate the access scheme that organizes multiple APs into respective AP group (APG) cooperatively to provide access service for each user, aiming at maximizing the system energy efficiency. First, considering the users’ requirement and network environment, a grouping evaluation model is set up to organize APG efficiently. Then, we formulate the resource allocation problem of APG as a mix-integer non-linear programming problem, which is hard to tackle. For tractability purpose, we transform this problem and propose low-complexity algorithms based on matching and differ of convex programming theories to obtain a feasible solution. Extensive simulation results are presented to demonstrate the significant performance improvement compared with the existing schemes.
Nanofunctionalisation for the Treatment of Peripheral Nervous System Injuries

A construct based on the electrostatic layer-by-layer self assembly technique has been fabricated, to be used as a tailored device to encourage nerve regeneration. A multilayered nanocoating composed by three precursor bilayers of cationic and anionic polyelectrolytes followed by bilayers of poly-D-lysine (PDL) and antibody specific to transforming growth factor beta1 (anti-TGF-beta1) has been deposited on HYAFF 11reg. Initially the assembly process has been monitored by quartz crystal microbalance (QCM) in order to select the optimal working conditions for nanocoating deposition. Structural studies of the resulting multilayers confirmed stepwise deposition of anti-TGF-beta1 with an average layer thickness of 2.6 nm and an average layer mass of 117 ng. Atomic force microscopy has been used to characterize multilayer uniformity. Finally, the immunological activity of the multilayered structure has been assessed. The results show that anti-TGF-beta1 can be included in its active form in a predetermined multilayered structure onto HYAFF11reg with quantitative control of layer thickness and weight, providing a high potential tool in tissue engineering
Cascaded formation control using angle and distance between agents with orientation control (part 2)

In this paper and its companion paper [1], multi-agent formation control with obstacle collision avoidance for angle-distance-based formations with orientation control is considered. We propose an approach that uses information about the angle and distance between agents to achieve a leader-follower formation. First, we provide cascaded control laws with collision avoidance for groups of agents with unicycle models and prove the asymptotic stability of the formation. The non-holonomic unicycle model includes the vehicle dynamics. Second, the proposed control law is combined with displacement-based formation control. The shape of the formation is controlled by distance-angle-based formation control and the orientation of a group of agents converges to the desired orientation by a displacement-based control law. Simulation results are presented to illustrate the proposed controllers.
The Evaluation of the Running Speed and Agility Performance in Professional and Amateur Soccer Players

Kaplan, T, Erkmen, N, and Taskin, H. The evaluation of the running speed and agility performance in professional and amateur soccer players. J Strength Cond Res 23(3): 774-778, 2009-The professional and amateur soccer players were tested to determine the running speed and agility performance by playing positions. The sample included 108 professional male soccer players at the national level and 79 amateur male soccer players at a regional level on teams from 10 clubs in Turkey. The study involved the players being assessed by the 10- × 5-m shuttle run test ( 10 × 5 SRT) on a soccer field in a soccer season. The difference between the mean scores of the professional and amateur players is significant. Differences between mean scores according to playing positions of soccer players are not significant. In conclusion, professional soccer players' running speed and agility performances are higher than amateur soccer players. In addition, these results indicate that all soccer players have the same running speed and agility performance in accordance with their different playing positions. Coaches should consider individual training programs based on the positional role of soccer players.
The fibrosis marker galectin‐3 and outcome in the general population

Abstract. de Boer RA, van Veldhuisen DJ, Gansevoort RT, Muller Kobold AC, van Gilst WH, Hillege HL, Bakker SJL, van der Harst P (University of Groningen). The fibrosis marker galectin‐3 and outcome in the general population. J Intern Med 2012; 272: 55–64.