Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of slow-wave activity and slow-wave oscillations prior to somnambulism.

UNLABELLED STUDY OBJECTIVIES: several studies have investigated slow wave sleep EEG parameters, including slow-wave activity (SWA) in relation to somnambulism, but results have been both inconsistent and contradictory. The first goal of the present study was to conduct a quantitative analysis of sleepwalkers' sleep EEG by studying fluctuations in spectral power for delta (1-4 Hz) and slow delta (0.5-1 Hz) before the onset of somnambulistic episodes. A secondary aim was to detect slow-wave oscillations to examine changes in their amplitude and density prior to behavioral episodes. PARTICIPANTS twenty-two adult sleepwalkers were investigated polysomnographically following 25 h of sleep deprivation. RESULTS analysis of patients' sleep EEG over the 200 sec prior to the episodes' onset revealed that the episodes were not preceded by a gradual increase in spectral power for either delta or slow delta over frontal, central, or parietal leads. However, time course comparisons revealed significant changes in the density of slow-wave oscillations as well as in very slow oscillations with significant increases occurring during the final 20 sec immediately preceding episode onset. CONCLUSIONS the specificity of these sleep EEG parameters for the occurrence and diagnosis of NREM parasomnias remains to be determined.
A Taxonomical Classification of Business Models on Mobile Business: Patent Analysis and SOM Mapping

With the increased interest of m-business, there have been a lot of studies about the business model (BM) on m-business in not only academic field but also commercial field. Among them, the classification of m-BM and analysis of BM patents are some of the main topics in the BM research areas. Previous researches on the classification of m-BM and BM patents can give us the initiating issues of BM on m-business but they are subject to some limitations. The main objective of this paper is to suggest an inductive taxonomical approach for classifying BMs on m-business with a view point of BM structure and compare it with some typological classifications. Specifically, the approach applies a quantitative analysis by employing BM patents. 9 clusters are found by clustering analysis with SOM (self-organizing map) and they are analyzed with citation analysis. They are also compared with some typologies. The result of this study could be used as a basic framework or starting point of the quantitative analysis of BM on m-business
Cineradiographic demonstration of pharyngeal area myotonia in myotonic dystrophy patients.

The hereditary syndrome of myotonia and dystrophy of skeletal muscle, autonomic vascular and alimentary disorders, testicular atrophy and frontal baldness in males, and cataracts is well reported (1, 4, 9-12, 16). The myotonic dystrophy syndrome is identified e1ectromyographically by prolonged muscular contraction and a siren-like decrescendo termination. Dysphagia is described frequently in the histories of these patients (9–11, 20, 24, 25). It is recognized as a mechanism of recurrent pneumonia (17, 25) and as a major element in the later stages of the deterioration of persons with this affliction. The cineradiography of pharyngeal dysphagia associated with far-advanced myotonic dystrophy was described in two patients by Silverstein et at. (24) and in one patient by Kramer et al. (14). In each instance the disability was so far-advanced as to be essentially nonspecific in pattern and comparable to that in severe cases of amyotrophic lateral sclerosis (7, 14, 25). In the myotonic dystrophy patients of th.
Short- and Long-Term Risks After Exposure to Diagnostic Ultrasound In Utero

A total of 425 children exposed to diagnostic ultrasound at three Denver hospitals during the period May, 1968, through August, 1972, and 381 matched control children were studied for adverse effects at birth and again at a special examination between seven and 12 years of age. Apgar scores, gestational age, head circumference, birth weight, length, congenital abnormalities, neonatal infection, and congenital infection were measured at birth. At seven to 12 years of age, measurements included conductive and nerve measurements of hearing, visual acuity and color vision, cognitive function, behavior, and a complete and detailed neurologic examination. No biologically significant differences between exposed and unexposed children were found.
Study Design and Implementation of the PINE Study

Objective: Multiple barriers in research participation have excluded the Chinese older adults from benefitting the recent advancement of aging sciences. The paucity of systematic understanding of Chinese aging population necessitated the P opulation-Based Study of Ch IN ese E lderly in Chicago (PINE). Method: Guided by community-based participatory research approach, the PINE study is a population-based epidemiological study of Chinese older adults aged 60 and above in the Greater Chicago area. Results: We described study design and implantation of the PINE study, highlighting strategies in adapting a population-based study design to the Chinese community. These measures included community-engaged recruitment, innovative data collection methods, and culturally and linguistically sensitive study infrastructure. Discussion: The intricate cultural and linguistic diversity among U.S. Chinese older adults, coupled with their demographic characteristics and residential pattern, present challenges and opportunities in implementing a population-based study of older adults. Implications for the research and practice in relation to future minority aging and social sciences studies are discussed.
Proposition pour accroître la puissance convertible par un ensemble onduleur de tension - machine synchrone à commutation de flux à double excitation dans une application motorisation de véhicule hybride ou électrique

Les machines synchrones associees a leur onduleur de tension sont generalement pilotees en courant. Dans cet article, nous nous interessons a la commande en pleine onde de tension. La seconde partie decrit les performances attendues avec ce mode de commande. Dans la troisieme partie, nous presentons une machine synchrone a commutation de flux a double excitation (MSCFDE), dont les caracteristiques en font une candidate potentielle pour la motorisation electrique des vehicules hybrides ou electriques. Dans la quatrieme partie, sont presentes les resultats experimentaux de cette MSCFDE comportant des aimants permanents ferrite (Br = 0,4T), alimentee en pleine onde de tension, pour convertir le maximum de puissance. Dans la derniere partie, nous presentons deux solutions originales, pour accroitre cette puissance maximale convertible.
Discriminative low-rank metric learning for face recognition

Metric learning has attracted increasing attentions recently, because of its promising performance in many visual analysis applications. General supervised metric learning methods are designed to learn a discriminative metric that can pull all the within-class data points close enough, while pushing all the data points with different class labels far away. In this paper, we propose a Discriminative Low-rank Metric Learning method (DLML), where the metric matrix and data representation coefficients are both constrained to be low-rank. Therefore, our approach can not only dig out the redundant features with a low-rank metric, but also discover the global data structure by seeking a low-rank representation. Furthermore, we introduce a supervised regularizer to preserve more discriminative information. Different from traditional metric learning methods, our approach aims to seek low-rank metric matrix and low-rank representation in a discriminative low-dimensional subspace at the same time. Two scenarios of experiments, (e.g. face verification and face identification) are conducted to evaluate our algorithm. Experimental results on two challenging face datasets, e.g. CMU-PIE face dataset and Labeled Faces in the Wild (LFW), reveal the effectiveness of our proposed method by comparing with other metric learning algorithms.
Effect of Cry3Bb Bt Corn and Tefluthrin on Postdispersal Weed Seed Predation

Abstract Indirect effects of insect control strategies on weed populations are important to consider when developing robust integrated pest management strategies. Weed seed predation rates were investigated in corn managed under three contrasting treatments based on control practices for corn rootworm: (1) the transgenic crop Cry3Bb Bt corn, (2) the broad-spectrum insecticide tefluthrin, and (3) no insecticide control. This 2-yr field study conducted near Ithaca, NY, involved quantifying seed loss from velvetleaf, common lambsquarters, and giant foxtail in arenas with and without vertebrate exclosures. Velvetleaf and giant foxtail were unaffected by the insecticide treatment; however, average seed predation of common lambsquarters was lower in both the Bt corn (11.9%) and insecticide-treated plots (11.8%) compared with control plots (17.5%) that did not receive any insecticide. Seed predation of common lambsquarters was not affected by the vertebrate exclosure. Lower seed predation in the transgenic Bt corn and insecticide treatments was likely due to nontarget effects on carabids (Coleoptera: Carabidae). Although the reduction in seed predation was modest and limited to only one of the three weed species tested, our results highlight the need for greater risk assessment that includes the ecosystem service of weed seed predation when considering insect pest management options. Nomenclature: Common lambsquarters, Chenopodium album L. CHEAL; corn rootworm, Diabrotica spp. ; giant foxtail, Setaria faberi Herm. SETFA; velvetleaf, Abutilon theophrasti Medik. ABUTH; corn, Zea mays L; Bacillus thuringiensis var. kumamotoensis.
Korea’s Online Gaming Empire

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Discovery of Hedgehog Antagonists for Cancer Therapy.

BACKGROUND The evolutionarily conserved Hedgehog (Hh) signaling cascade is one of the key mediators of embryonic development of many metazoans. This pathway has been extensively targeted by small molecule inhibitors as its misregulation leads to various malignancies and developmental disorders. Thus, blocking this pathway can be a novel therapeutic avenue for the treatment of Hedgehog-dependent cancers. This review covers the mechanism of hedgehog signaling in vertebrate cells, provides an overview of reported small molecule Hh pathway inhibitors, with the synthetic routes and SAR studies of some of them discussed briefly. METHODS A comprehensive survey of literature related to synthetic and naturally occurring Hh signaling antagonists reported till date is presented. RESULTS Given the selectivity of small molecules targeting, this pathway for cancer treatment compared to kinase, tubulin or HDAC inhibitors, several such antagonists have been discovered, of which some are in preclinical development and clinical studies. Most of the reported small molecules primarily antagonize the Smoothened receptor although agents targeting Gli1 transcription factor and Shh ligand have also been discovered. Till date, nine Smo antagonists have been evaluated in clinical trials.GDC- 0449/Vismodegib and NVP-LDE225/Erismodegib, were granted approval by the U.S. Food and Drug Administration (U.S. FDA) for the treatment of basal cell carcinoma. CONCLUSION The challenge is to identify agents that target the pathway downstream of Smo and develop strategies to overcome acquired drug resistance to the current Smo inhibitors with deeper understanding of the resistance mechanisms.
Fenitrothion-induced cell malformations in vitro in Spodoptera exigua cell line UCR-Se-1

According to our previous observations, larvae of the moth Spodoptera exigua can develop resistance to the phenyl organothiophosphate insecticide fenitrothion, and survive long-term exposure to it. Therefore we examined the effect of similar fenitrothion doses on cell structure in S. exigua cell line UCR-Se-1. The treatment resulted in several kinds of ultrastructural changes in these cells. The most prominent were malformations in mitochondrial and nuclear structure: swelling of the nuclear envelope and extension of perinuclear space, improper organization of genetic material (enhanced ratio of condensed chromatin), destruction of mitochondria (loss of cristae), and presence of electron-lucent spaces within the matrix. The cytoplasm was heterogeneous, with electron-lucent vesicles. The observed malformations became more evident with prolonged exposure to fenitrothion. Finally, disintegration of several cells was noted. We suggest that fenitrothion may act directly on cell organelles, apart from its known blocking effect on synaptic transmission.
An integrated fluorescence array as a platform for lab-on-a-chip technology using multimode interference splitters

We present the design and fabrication of 1-to-N multimode interference (MMI) splitters, suitable for use in integrated optical fluorescence array sensing, with particular applications in lab-on-a-chip (micro-TAS) technologies. Electron beam irradiation of germanium-doped flame hydrolysis deposited silica was used to define the MMI waveguide regions. The splitters were integrated with microfluidic channels to form direct-excitation fluorescence sensor chips for use at visible wavelengths. Characterization of the waveguides shows that predictable splitting ratios can be achieved. Two devices are presented: a 1/spl times/2 splitter integrated with one analytical chamber and a 1/spl times/4 array device for multipoint excitation. A photomultiplier tube was used to assess the analytical performance of the chip, in response to standard aliquots of fluorophore (31 nM to 1.25 /spl mu/M).
A programmable plug&play interface for WSN applications

Cost reduction in Wireless Sensor Networks (WSN) becomes a must to extend their application to fields where a great amount of sensors is needed. In those cases, the use of smart sensors is expensive, consequently requiring the use of low-cost sensors followed by a versatile electronic interface able to adapt all the sensors used. This paper presents the design of a flexible interface, compatible with the most common types of analog sensors used in WSNs and with the property of self-configuration for each sensor. The proposed interface includes both electronic and software elements.
Towards the Ideal Artificial Circulating Fluid for the Isolated Frog's Heart

Two years ago Albanese' published an investigation of the necessary conditions to be fulfilled by a circulating fluid for the isolated frog's heart which is made to do real mechanical work. These conditions, according to Albanese were (1) isotony with frog's blood; (2) the possession of a certain amount of viscosity; (3) a degree of alkalinity suifficient to remove the acid products of metabolism; (4) a supply of free oxygen. These conditions were all fulfilled by the use of a solution containing *6 0/0 NaCI, 2 0/0 ordinary gum arabic, and a trace of NasCO3, kept saturated with oxygen by the passage of a stream of the gas through it. This gave admirable results. As however Albanese was unable to corroborate Ringer's results as to the importance of Calcium and Potassium for the frog's heart, and as the non-recognition of their importance in the Strassburg Pharmacological Institute may tend to hinder the general recognition of their importance in metabolic processes of which I miyself have had ample proof, I publish now a small part of a more general investigation having as object the clearing away of some at any rate of the numberless discrepancies in this small branch of experinmental physiology. Gum arabic consists chemically of the potassium, magnesium, and calcium salts of arabic and similar acids. These acids can be prepared in the free state, then containing no ash, by repeated treatment of the aqueous solution of the gum with hydrochloric acid followed by precipitation with alcohol. This I have done and find that a 2 0/0 solution of the sodium salt of the acid or mixture of acids in *6 0/0 salt solution, made weakly alkaline with Na2CO3, and saturated with oxygen, stops the heart like alkaline salt solution, its activity recommencing when the necessary amounts of calcium and potassium chlorides are added, there being good recovery too of its absolute force.
Injury rates and profiles in female ice hockey players.

BACKGROUND Little data exist on injury rates and profiles in female ice hockey players. OBJECTIVE To examine the incidence of injury in female ice hockey players and compare injury rates with those of male players. STUDY DESIGN Prospective cohort study. METHODS Six male and six female teams from the Canada West Universities Athletic Association were followed prospectively for one varsity season. Preseason medical history forms were completed by each player. Injury report forms and attendance records for each team session were submitted by team therapists. RESULTS Male players reported 161 injuries, whereas female players reported 66 injuries. However, the overall injury rates for male (9.19 injuries per 1000 athlete-exposures) and female (7.77 injuries per 1000 athlete-exposures) players did not differ significantly. Ninety-six percent of injuries in female players and 79% in male players were related to contact mechanisms, even though intentional body checking is not allowed in female ice hockey. Women were more likely than men to be injured by contacting the boards or their opponent. Men sustained more severe injuries than women and missed about twice as many sessions (exposures) because of injury. Concussions were the most common injury in female players, followed by ankle sprains, adductor muscle strains, and sacroiliac dysfunction. CONCLUSION Although the injury rate in female ice hockey players was expected to be lower than that in male players because of the lack of intentional body checking, the injury rates were found to be similar.
Role of Toll-Like Receptor 9 in Legionella pneumophila-Induced Interleukin-12 p40 Production in Bone Marrow-Derived Dendritic Cells and Macrophages from Permissive and Nonpermissive Mice

ABSTRACT The progression of Legionella pneumophila infection in macrophages is controlled by the Lgn1 gene locus, which expresses the nonpermissive phenotype in cells from BALB/c mice but the permissive phenotype in cells from A/J mice. Activation of dendritic cells and macrophages by L. pneumophila is mediated by the pathogen recognition receptor Toll-like receptor 2 (TLR2); furthermore, Legionella induces innate and adaptive immune cytokines by the MyD88-dependent pathway. TLR9 is coupled to MyD88 and mediates the production of interleukin-12 (IL-12) in dendritic cells infected with other facultatively intracellular pathogens. In the current study, L. pneumophila growth in dendritic cells from BALB/c and A/J mice was examined along with the role of TLR9 in the induction of IL-12 in these cells. Dendritic cells from both strains were nonpermissive for L. pneumophila intracellular growth, suggesting that the products of the Lgn1 gene locus that control intracellular growth in macrophages do not control the growth of Legionella in dendritic cells. In addition, chloroquine treatment suppressed IL-12 p40 production in response to Legionella treatment in dendritic cells and macrophages from BALB/c and A/J mice. Furthermore, the TLR9 inhibitor ODN2088 suppressed the Legionella-induced IL-12 production in dendritic cells from both mouse strains. These results suggest that L. pneumophila is similar to other intracellular bacteria in that it stimulates the production of immune-transitioning cytokines, such as IL-12, through activation of TLR9 and that this receptor provides a common mechanism for sensing these types of microbes and inducing innate and adaptive immunity.
Interface syntaxe-sémantique au moyen d’une grammaire d’arbres adjoints pour l’étiquetage sémantique de l’arabe (Syntax-semantic interface using Tree-adjoining grammar for Arabic semantic labeling)

Dans une grammaire formelle, le lien entre l’information sémantique et sa structure syntaxique correspondante peut être établi en utilisant une interface syntaxe/sémantique qui permettra la construction du sens de la phrase. L’étiquetage de rôles sémantiques aide à réaliser cette tâche en associant automatiquement des rôles sémantiques à chaque argument du prédicat d’une phrase. Dans ce papier, nous présentons une nouvelle approche qui permet la construction d’une telle interface pour une grammaire d’arbres adjoints de l’arabe. Cette grammaire a été générée semi automatiquement à partir d’une méta-grammaire. Nous détaillons le processus d’interfaçage entre le niveau syntaxique et le niveau sémantique moyennant la sémantique des cadres et comment avons-nous procédé à l’étiquetage de rôles sémantiques en utilisant la ressource lexicale ArabicVerbNet.
Pour une évaluation globale des OGM : Des perspectives épistémologiques renouvelées pour l'analyse des risques

L'evaluation des technologies telle qu'elle se pratique actuellement reste dans l'esprit des enquetes de commodo et incommodo, ou on cherche a mettre en balance les avantages et les inconvenients, pour des personnes concernees, de telle ou telle innovation. La base de la demarche reste l'estimation des avantages et des risques, le tout dans un contexte de jugement qui n'est pas precise et qui se comporte comme un « deja-la » omnipresent. Un jugement de valeur (bon/mauvais, avantage/inconvenient.) ne se pose pas dans l'absolu. Ce qui est bon pour quelqu'un, dans un certain contexte de sens, n'est pas forcement bon pour un autre et peut meme se faire au detriment de l'autre. L'etablissement d'une ethique ou d'une morale va permettre deja d'etablir une hierarchie, en posant que l'interet general prime l'interet particulier. Encore faut-il que ce que sont l'interet et le risque soient pourvus d'un sens coherent avec les realites du monde et cette reflexion doit constituer la premiere etape de l'approche de la notion d'evaluation, faute de quoi on assimilerait cette demarche a un rituel tres inadapte a nos besoins actuels, debouchant sur un pilotage a l'aveugle d'une technologie galopante. L'ethique generale, concue comme representant l'ensemble (explicite et implicite) de ce qui conduit la pensee et les actes vers l'interet general, constituant ainsi le contexte global des jugements de valeur, a pourtant ete, de facto, ecartee de la reflexion et du debat pour ce qui concerne au moins les biotechnologies, par l'analyse au cas par cas. Dans cette demarche, proposee, voire imposee, par l'industrie des biotechnologies, le contexte ethique est rejete hors de l'evaluation. C'est la raison pour laquelle nous avons propose a Jean-Francois Dhainaut, alors president du Haut Conseil des Biotechnologies (HCB), de constituer, dans le cadre de cette institution, un groupe de travail sur l'ethique generale ayant pour but de jeter les bases d'une evaluation des biotechnologies s'inscrivant dans un contexte de sens adapte aux conditions modernes