Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of a routine outcome monitoring instrument for use with clients in the New Zealand Alcohol and Other Drug treatment sector: the Alcohol and Drug Outcome Measure (ADOM)

This paper describes the development and evaluation of the Alcohol and Drug Outcome Measure (ADOM), a brief 18-item, two part, outcome monitoring instrument designed for routine use with clients in the New Zealand Alcohol and Other Drug (AOD) treatment sector. The development of the ADOM was informed by an expert panel of AOD clinicians (n = 6), key informant interviews (n = 14) and a pilot with AOD treatment clients and their respective clinicians (n = 25). The psychometric properties of the ADOM were tested with clients (n = 63) across a range of AOD treatment services. Testing involved clinicians administering the ADOM at treatment admission, one-to-seven days post-admission, and four-to-six weeks post-admission. Analyses of the test-retest reliability, concurrent validity and sensitivity to change of Part A of the ADOM, covering type and frequency of substance use, consistently produced excellent results. Comparable results for Part B of the instrument, covering associated psychosocial issues, were generally satisfactory. The ADOM has the potential to be used as a core AOD outcomes monitoring instrument.
Control design for the PVTOL aircraft with arbitrary bounds on the acceleration

In this paper, a simple control algorithm for the PVTOL aircraft is proposed. The control strategy takes into the account input constraints and does not have any singularities. The control design is such that the acceleration satisfies arbitrary bounds. The stability analysis is proved by using very simple arguments. Satisfactory behavior is shown in simulations.
Cis–Acting RNA Elements of Human Immunodeficiency Virus

The World Health Organization has indicated that effective control of the HIV/AIDS pandemic is the world’s most urgent public health challenge. The 2009 UNAIDS Global Facts and Figures report estimated that almost 60 million people have been infected with the virus and that 25 million AIDS-related deaths have occurred since the pandemic began in the early 1980s. In 2008, there were approximately 33.4 million people living with HIV, 2.7 million new infections and 2 million deaths from AIDS-related causes. The pathogen that causes this pandemic is the Major (M) group of HIV type 1 (HIV-1). Group M HIV-1 dominates the global pandemic with at least nine subtypes and multiple intersubtype recombinants have been identified to date (Leitner et al., 2005). Many of these recombinants are circulating in multiple geographical regions and are integral parts in the HIV-1 pandemic (McCutchan, 2006; Takebe et al., 2004).
Bases genéticas de los trastornos del neurodesarrollo

En la ultima decada, los avances de la genetica estan cuestionando el actual modelo nosologico implicito en el Manual diagnostico y estadistico de los trastornos mentales, cuarta edicion, texto refundido (DSM-IV-TR) y la Clasificacion Internacional de Enfermedades, decima revision. Tanto el caracter categorico como la comorbilidad detectada a partir de la aplicacion de los criterios diagnosticos resultan insostenibles a la luz de la arquitectura genetica que esta emergiendo a partir de los estudios sobre la genetica de los trastornos mentales. Los paradigmas clasicos, un gen para una enfermedad, o, incluso, un patron genetico especifico y distintivo para cada entidad, son conceptos que quedan restringidos a casos concretos. En la presente revision se pretende describir el panorama actual configurado tras los recientes avances geneticos. Las lineas de trabajo que estan marcando la investigacion en el presente y en el futuro inmediato son: la identificacion de variantes en el numero de copias -frecuentes y raras-, vinculadas de modo indiscriminado a distintos trastornos; la concurrencia simultanea de multiples variantes para un mismo trastorno; el fenomeno del doble impacto; y la modulacion epigenetica. La nueva version del DSM, consciente de las deficiencias en el modelo vigente, marcara un punto de inflexion, timido, pero decididamente orientado a incorporar una concepcion dimensional de los trastornos mentales.
The relative importance of specific and nonspecific factors in child behavior therapy

The relative importance of the technique versus the relationship in child behavior therapy was investigated. Parents of 47 children who were receiving behavior therapy rated the importance of these variables and how they were related to therapeutic outcome. Overall findings were that the relationship was rated as significantly more important than specific techniques. However, when associations with therapy outcome were examined, it was found that only technique was significantly related to outcome but that the correlations between technique and outcome and between relationship and outcome were not significantly different from each other. These findings are in agreement with studies showing that technique and relationship are intertwined and are both influential to differing degrees depending on the unique problem brought to therapy.
Universal health coverage: Current status and future roadmap for India

Universal health coverage (UHC) has been recognized as the most important immediate goal for global health. Attempting to achieve this goal for the country, the Government of India, has been taking measured steps, trying to ensure equitable access to high-quality affordable health-care services for all citizens. This article attempts to identify the success of these efforts through a baseline situation assessment of UHC dimensions in India, followed by a critical analysis of what is being done to fulfill the gaps, and finally propose a health policy roadmap for UHC with implications at national and state level. Literature review presents a varied scenario with respect to the coverage of key services essential for service packages, reflecting need for significant improvement. Large-scale inequities in health-care service delivery and health indicators have been observed, with poor financial risk protection of the community from catastrophic spending on health care. Various reasons for this were identified, such as low public investment in health services, poor health-care service delivery system, poor quality of services offered to the community, and lack of robust financial protection mechanisms. The study proposes a contextual restructuring of the health system, initiating with an increase in financial investments in public health-care sector. This should be supplemented with health system strengthening by improving overall service availability for the community with optimal quality and at low cost. Private sector service provisioning should be regulated by developing and implementing strong accountability measures. The governance capacity of public sector should be augmented to improve success rates of the demand-side financing schemes. Health technology assessments should become the mainstay of taking decisions on benefit package. A holistic multipronged approach constituting all these changes is required if health coverage has to be made universal in the country.
Combiner des modèles sémantiques distributionnels pour mieux détecter les termes évoquant le même cadre sémantique (Combining distributional semantic models to improve the identification of terms that evoke the same semantic frame)[In French]

Nous utilisons des modèles sémantiques distributionnels pour détecter des termes qui évoquent le même cadre sémantique. Dans cet article, nous vérifions si une combinaison de différents modèles permet d’obtenir une précision plus élevée qu’un modèle unique. Nous mettons à l’épreuve plusieurs méthodes simples pour combiner les mesures de similarité calculées à partir de chaque modèle. Les résultats indiquent qu’on obtient systématiquement une augmentation de la précision par rapport au meilleur modèle unique en combinant des modèles différents.
The Prevalence of Hepatitis B Virus in Female Commercial Sex Workers

Background: The prevalence of hepatitis B infection in Indonesia was about 2-20%. To date, incidence rate of Hepatitis B Virus (HBV) in female Commercial Sex Workers (CSW) in Manado was not known. Objective: To investigate the prevalence and risk factors associated with HBV in female CSW. Methods: This is a descriptive-analytic study with cross-sectional design. Target population was female CSW in Manado. Results: Of 177 subjects, age range 15-49 years (27.87 ± 7.629), the most frequent age were 20-24 years with 56 subjects (31.6%). Serum HBsAg was positive in 8 (4.5%) subjects. Serum HBsAg was positive in 8 of 143 (5.6%) subjects with intercourse frequency > 5 times weekly, 8 of 142 (5.6%) subjects with sexual partner > 5 per week, 1 of 41 (2.4%) subject worked as CSW < 1 year, 7 of 136 (5.1%) subjects worked as CSW for more than a year, and 1 of 110 (0.9%) subjects who used condom. Conclusion: Prevalence rate of hepatitis B in female CSW in Manado was 4.5%. There was significant relationship between condom usage and the prevalence of hepatitis B virus infection. There was relationship with some other risk factors but statistically insignificant. Keywords: hepatitis B virus, prevalence, commercial sex worker, condom usage
C31. Performance Evaluation of Speech CODECs against the Change in the Spoken Language and Accent

In all modern communications, speech coding plays a very vital role. It is a basic element in the efficient use of BW and QoS issues. Many standard bodies generate a series of speech coders with different rate, quality and delay combinations. Most of these CODECs have been built for 7 languages not including the Arabic or its accents. In this paper an extensive performance testing is done on the G.723. 1 and compared with the G711, μ_law and AMR. The test is done for (English, Arabic and Cairo accent) from different speakers' gender. The assessment was developed using the PESQ algorithm and it has been proved that the speech quality is slightly degraded when using Arabic language or Cairo accent with G.723. 1 or AMR coders. The main point is not only the slight degradation but also the less stability of the LP coders' performance when working with languages other than English.
Proteasome inhibitors: beyond NFKB inhibition alone and the emerging role of combination therapy in the treatment of multiple myeloma

Introduction The emerging role of novel agents has dramatically increased treatment options for patients with multiple myeloma (MM), with new agents including thalidomide, bortezomib and lenalidomide significantly improving outcomes for patients with both newly diagnosed and relapsed and refractory MM.1-5 Studies in early relapse suggest that both bortezomib and lenalidomide are more effective in patients who have received fewer prior therapies and provide a rationale to investigate their use in the frontline setting.6,7 As an example, the ability to safely combine bortezomib with other combinations and the consistent signal provided by informative pre-clinical studies has led to a number of important combination strategies in both the upfront and the relapsed and relapsed/refractory settings (Figure 1). The role of NFKB as a key therapeutic target has thus been validated, and beyond NFKB the importance of other downstream targets has become established, as combination therapies have shown activity even in highly resistant MM.8,9 Early clinical studies with small molecules and monoclonal antibodies have likewise demonstrated that there are a number of promising new agents in clinical development that when combined with established platforms of bortezomib- based therapies may provide additional treatment options for patients with relapsed and refractory disease.
Efecto del donepecilo comparado con el tratamiento convencional en la función cognitiva y el rendimiento del paciente en una cohorte prospectiva de pacientes con enfermedad de Alzheimer tratados en la práctica clínica habitual en España

AIMS: Our aim was to perform a secondary analysis of a 12-month-long, non-blind, multi-centre prospective cost-of-illness study. The analysis assessed the effect of donepezil on cognitive functioning and the performance of patients with possible or probable Alzheimer's disease, compared to that of other drugs for dementia. PATIENTS AND METHODS: A sample of 700 patients took part in the study (76.8 ± 6.6 years of age, 67.3% females): 600 (31.4% drug-naive) received donepezil and 100 (9% drug-naive) were given other drugs for dementia. RESULTS: The mean variations corrected by the baseline values and the centre of the total scores on the Folstein minimental test, the clinical dementia rating and Blessed dementia rating scales at 12 months were significantly lower in patients treated with donepezil: -1.23 ± 3.41 versus -2.26 ± 3.07 (p = 0.006), 0.20 ± 0.68 versus 0.39 ± 1.03 (p = 0.014) and 1.28 ± 3.31 versus 2.04 ± 2.84 (p = 0.027), respectively. CONCLUSIONS: This secondary analysis shows that the deterioration in the cognitive functioning and performance of patients with the passage of time is slower with donepezil than with other drugs for dementia in routine medical practice. Since these results were observed in a post hoc analysis, formal prospective clinical trials should be conducted to confirm these findings.
Safety evaluation of Bifidobacterium breve MCC1274 via oral toxicity tests in rats

In this study, the safety of Bifidobacterium breve MCC1274, a probiotic bifidobacterial strain, was assessed by single-dose and 90-day repeated-dose oral toxicity studies. In the single-dose oral toxicity assay using 6000 mg/kg of B. breve MCC1274 corresponding to 8.4 × 1011 colony-forming unit (CFU)/kg, mortality and adverse effects were not observed. Furthermore, the administration of 1000 mg/kg of B. breve MCC1274 by oral gavage in saline for 90 days did not induce any signs of toxicity, such as changes in clinical signs, body weight (BW), food consumption, ophthalmoscopy, urinalysis, hematology, blood chemistry, organ weight, gross pathology, and histopathology compared to the control group given cornstarch in saline (10/sex/group). The no-observed-adverse-effect-level of B. breve MCC1274 in the 90-day repeated-dose toxicity study was greater than 1000 mg/kg corresponding to 1.3 × 1011 CFU/kg. Based on the findings of this study, the acceptable daily intake of B. breve MCC1274 was calculated to be 1.3 × 109 CFU/kg BW/day.
Aging Affects the Response of Heart Rate Variability Autonomic Indices to Atropine and Isoproteronol

Background: Normalized ratios of portions of the power frequency spectrum of heart rate (HR) are commonly used to gain insight into cardiac “sympathovagal balance. ” Whether aging, which alters both sympathtetic and parasympathetic activities, infl uences these measures has not been well characterized. Objectives: We examined the ability of normalized ratios of the power frequency spectrum of heart rate to describe autonomic activity at the sinus node in older and younger adults during conditions of sympathetic predominance. Methods: 20 older (mean age 70.0 ± 1.5 years) and 24 younger (mean age 25.4 ± 0.9 years) normal adults were screened by history, physical examination, blood work (CBC, electrolytes, creatinine, liver function tests), ECG, exercise tolerance test, echocardiogram and myocardial perfusion scan (if � 65 years old). A 2-channel Holter was used to monitor heart rate. Total (TP), low frequency (LF) and high frequency power (HF) were obtained by Fast Fourier Transform. Intravenous atropine (2 boluses of 0.01 mg/kg) was followed by isoproterenol infusions of 7 and 21 ng/kg/min to tilt the “sympathovagal balance” to the sympathetic nervous system side. Results: Normalized HF power gave expected results in response to atropine only in younger subjects. Changes in normalized LF power had a much stronger correlation with changes in heart rate in older as opposed to younger subjects.
The relation between polychlorinated biphenyls and population metrics of 4 species of fish from the upper Hudson River, New York, USA

In the upper Hudson River, New York, USA, fish were exposed to polychlorinated biphenyls (PCBs) from the 1940s to 1977, and PCBs still persist in this environment. Yellow perch (Perca flavescens), brown bullhead (Ameiurus nebulosus), smallmouth bass (Micropterus dolomieu), and largemouth bass (M. salmoides) were collected annually from 2003 to 2009 from 1 control site upstream of the PCB discharge locations and from 2 sites downstream from where PCBs were released. Fish PCB concentrations were estimated, and 3 population metrics were examined: 1) relative abundance, 2) weight‐to‐length ratio, and 3) growth. Normalized lipid‐based PCB concentrations at the 2 PCB exposure pools averaged approximately 100 to 600 μg/g. Estimated relative abundances with electrofishing were higher for largemouth bass, smallmouth bass, and brown bullhead at PCB exposure sites compared to the control site; but yellow perch were more abundant at the control site. Weight to length ratios varied among sites and species, but no consistent pattern was evident in relation to PCBs at the population level or for individual fish. Growth rates for yellow perch and brown bullhead were similar among sites. Largemouth bass growth was slightly higher at the control site compared to the 2 PCB sites, but smallmouth bass growth was much higher at the PCB sites compared to the control site. We could not detect any relation or influence of PCBs on the 3 population metrics that we examined. the present results corroborated those of previous investigations concerning the effects of PCBs on fishes. We recommend stronger consideration of the biological impacts of PCBs at the population level when conducting risk assessments. Environ Toxicol Chem 2019;38:329–339. © 2018 SETAC
Situación actual y control de la rabia en el Perú

Rabies is an endemic disease of Peru, that appears in two cycles, one urban related with transmission by dog, and another wild caused mainly by vampires bats bite. Most of human cases of the last decades they have been by urban rabies, nevertheless the used measures of control (canine vaccine campaigns, vaccine production, identification of biting dog, opportune attention of the victim and surveillance and notification system) they have managed to reduce the incidence of canine rabies and therefore of the human cases. Currently the greater number of human cases notified are caused by Desmodus rotundus in Peru.
Left-inversion soft-sensor of synchronous generator

SUMMARY The online measurement of some crucial variables in synchronous generator (such as the power angle, the d-axis and q-axis transient electric and magnetic fields, and the d-axis and q-axis stator circuit currents) is very important in many applications, but they are difficult to be measured by ordinary sensors. In the paper, these variables are estimated (soft-sensed) on the basis of the online directly measurable variables of generator (such as the active and reactive powers and the amplitude of current). First, a new model of synchronous generator is proposed, which fully includes the online measurable variables of synchronous generator and is suitable for designing soft-sensors. Second, aiming at the specialty of the proposed model (a typical kind of nonlinear differential-algebraic subsystem), the original left-inversion soft-sensing algorithm proposed in a previous paper is expanded. Then a left-inversion soft-sensor is designed while the fourth-order transient practical model of synchronous generator is considered, and all of the to-be-estimated variables are soft-sensed. Finally, the simulation is performed on the basis of MATLAB/SimPowerSystems (MathWorks, Natick, MA, USA), in which the sixth-order subtransient practical model of generator is used to simulate the real generator, and the results demonstrate the validity of the proposed method. Copyright © 2011 John Wiley & Sons, Ltd.
The Apache Modules Book: Application Development with Apache

"Do you learn best by example and experimentation? This book is ideal. Have your favorite editor and compiler readyi? you'll encounter example code you'll want to try right away. You've picked the right booki? this is sure to become the de facto standard guide to writing Apache modules. "i? Rich Bowen, coauthor, Apache Administrators Handbook, Apache Cookbook, and The Definitive Guide to Apache mod_rewrite"A first-rate guide to getting the most out of Apache as a modular application platformi? sure to become a must-read for any Apache programmer, from beginner to experienced professional. It builds up carefully and meticulously from the absolute basics, while including chapters on everything from the popular Apache DBD Framework to best practices, security, and debugging. "i? Noirin Plunkett, documentation committer to the Apache httpd project, and member of the ASF conference committeeThe Only Comprehensive Guide to Developing Apache 2.x Modules and ApplicationsApache is more than the world's most popular Web serveri? it's also an extraordinarily powerful and extensible development platform. Now, ApacheTutor.org's Nick Kew has written The Apache Modules Book, the first start-to-finish, example-rich guide for every developer who wants to make the most of Apache.Kew begins with detailed, accessible introductions to Apache's architecture and API, then illuminates all the techniques you'll need, from request processing through code security. He brings together the best of both worlds: powerful C-based techniques for accomplishing tasks Perl or PHP can't handle, implemented with tools that deliver all the productivity you'd expect from higher-level languages.Utilizing realistic code samples, Kew introduces techniques documented in no other book-and, often, nowhere else at all.Coverage includes Using Apache Portable Runtime (APR) to streamline C development and avoid its pitfalls Leveraging Apache DBD to build applications far more scalable than classic LAMP software Working with the latest Apache 2.x features: filter modules, XML support, and smart proxies Mastering best practices, from thread safety to multi-platform development Utilizing the Apache Authentication Framework Tracing and debugging problems in both Apache and your custom modulesForewordPrefacei? AcknowledgmentsAbout the Authori? Chapter 1 Applications Development with Apache Chapter 2 The Apache Platform and Architecture Chapter 3 The Apache Portable Runtime Chapter 4 Programming Techniques and Caveats Chapter 5 Writing a Content Generator Chapter 6 Request Processing Cycle and Metadata Handlers Chapter 7 AAA: Access, Authentication, and Authorization Chapter 8 Filter Modules Chapter 9 Configuration for Modules Chapter 10 Extending the API Chapter 11 The Apache Database Framework Chapter 12 Module Debugging Appendix A Apache License Appendix B Contributor License Agreements Appendix C Hypertext Transfer Protocol: HTTP/1.1 Index About the Web SiteApacheTutor.org contains code examples from the book, all designed for easy use and integration into existing applications.