Miracle-dz/UniFAR-FTUs huggingface dataset:
Supporting Transition for Mathematics and Science Students under an Assumed Knowledge Approach

In Australia there is concern over the poor mathematical skills of students entering University STEM degrees (King & Cattlin, 2015). Challenged by the introduction of an assumed knowledge approach for mathematics dependent university degrees, we noted diagnostic testing approaches (Ní Fhloinn et al., 2014) and sought to adapt the successful GetSet2 quiz that previously had been applied only to pre-requisite mathematics university entry (Burton et al., 2013). We introduced the on-line self-assessment Get Ready Maths/Science quizzes for commencing science and mathematics students. This allowed students to receive timely personalised feedback on their level of knowledge and skills compared with the expected assumed/pre-requisite knowledge for university entry. This paper reviews the design, development and initial implementation of transition quizzes under the challenges of an assumed knowledge framework, instead of a pre-requisite framework.
Características clínico-epidemiológicas de las complicaciones agudas de la diabetes mellitus

Background: Diabetes mellitus causes acute and chronic symptoms, most of them can be avoided or modified. Early detection of undiagnosed diabetes mellitus may lead to tighter control or reduction in the severity of complications associated with this disease. Objective: To determine the prevalence and clinical characteristics of diabetes mellitus in patientes admitted to a public hospital of Merida, Yucatan, requiring emergency care. Patients and methods: A retrospective, cross-sectional, descriptive, and observational study was conducted in 877 diabetic patients attending the emergency room of Hospital Regional General Benito Juarez Garcia of Merida, Yucatan, from January through December 2003. Results: Acute complications occurred in 93 patients (34%): 82 patients (29.60%) suffered from hypoglycemia; six (2.1%) had hyperosmolar nonketotic state, and five patients (1.8%) developed diabetic ketoacidosis. Conclusions: Hypoglycemia was the most common symptom of diabetes mellitus in this group of patients, and it must be taken into account in order to prevent it. Social, cultural, and educational factors could predispose people to diabetes, apart from the complications mentioned above. Hyperosmolar nonketotic state and diabetic ketoacidosis were less frequent. The wide variety of baseline clinical manifestations resembled those found in large series of patients.
Expresiones cutáneas de candidiasis sistémica en pacientes inmunosuprimidos

Resumen La candidiasis sistemica constituye una importante causa de morbimortalidad en pacientes internados en centros de alta complejidad. Las expresiones cutaneas de la infeccion son multiples y se observan en un pequeno porcentaje de pacientes. Se presentan cinco casos de candidiasis sistemica con compromiso cutaneo en pacientes inmunosuprimidos: un paciente trasplantado de medula osea, dos pacientes con leucemia mieloide aguda, un caso de sepsis bacteriana y un paciente con linfoma linfocitico. Todos los pacientes presentaron fiebre persistente y lesiones cutaneas que se biopsiaron para estudio histologico y cultivo. La histopatologia mostro seudohifas en tres de los casos. En los cultivos de piel se identifi co a Candida tropicalis, Candida krusei y Candida albicans en dos pacientes. El incremento de cepas resistentes hace necesario el empleo de nuevos antifungicos como las equinocandinas para el tratamiento de esta entidad (Dermatol Argent 2010;16(5):337-343). Palabras clave: candidiasis sistemica, cepas resistentes, equinocandinas. Title: Cutaneous expression of systemic candidiasis in immunosuppressed patients Abstract Systemic candidiasis is a signifi cant cause of morbidity and mortality in immunosuppressed hospitalized patients. Skin signs of systemic candidiasis are numerous although they can be observed in a small percentage of patients. We report five cases of systemic candidiasis with cutaneous manifestations in immunosuppressed patients: one case of bone- marrow transplantation, two patients with acute myeloid leukaemia, one with bacterial sepsis and one patient with lymphocitic lymphoma. The patients presented persistent fever and cutaneous lesions. Skin biopsy for histopathological study and cultures were carried out. The histological examination showed yeasts in three of the cases. Skin culture revealed: Candida tropicalis, Candida krusei and Candida albicans in two cases. Due to the increase of resistant species new drugs such as echinocandins are currently available for the treatment of this entity (Dermatol Argent2010;16(5):337-343). Key words: systemic candidiasis, resistant species, echinocandins.
Tuberculosis control in a South African community with high HIV prevalence: the role of intensified case-finding and antiretroviral therapy

This thesis investigates active TB case finding and antiretroviral therapy for tuberculosis control in a setting with high HIV prevalence in Cape Town, South Africa. Many countries in sub-Saharan Africa have seen a worsening tuberculosis epidemic since the 1990s. Rising tuberculosis incidence rates have largely been attributed to high HIV prevalence in this region. Conventional tuberculosis control efforts focus on passive case finding and high cure rates in smear-positive patients, achieved through short course chemotherapy. These control strategies are insufficient in controlling the tuberculosis epidemic where HIV prevalence is high. Additional control strategies have been proposed, including active tuberculosis case finding, isoniazid preventive therapy for HIV infected individuals, infection control and antiretroviral therapy. The feasibility, uptake, yield, treatment outcomes and costs of population-based active tuberculosis case finding are investigated in the first part of the thesis. The second part determines losses along the HIV care pathway, community antiretroviral coverage and the association between coverage and tuberculosis risk. The main finding is that population-based active tuberculosis case finding linked to a mobile HIV testing service had a high uptake and yield. Treatment outcomes in patients diagnosed through active case finding were as good as outcomes in patients diagnosed through passive case finding in primary care clinics in Cape Town. Costs were USD 1,177 per TB case diagnosed and USD 2,458 per 3 successfully treated TB case, in an incremental costing analysis adopting a health service provider perspective. Analysis of the HIV care pathway in a peri-urban impoverished settlement in the greater area of Cape Town highlighted substantial losses along the pathway between HIV diagnosis and antiretroviral therapy. These results illustrate the operational challenges in achieving high treatment coverage. Antiretroviral coverage in this community increased from 18% in 2004 to 84% in 2009. Increasing antiretroviral coverage was associated with decreasing tuberculosis risk among patients receiving antiretroviral therapy, even controlled for timeupdated CD4 count, suggesting an effect on transmission, not just on individual risk reduction. The impact of active tuberculosis case finding and antiretroviral therapy on tuberculosis incidence on a population level was beyond the scope of this thesis. Large scale cluster randomized controlled trials are needed to investigate the effect of these strategies on tuberculosis control. In the meantime researchers conducting active tuberculosis case finding studies should be encouraged to collect data on treatment outcomes and costs. In addition further interventions are needed to increase retention and linkage to care in individuals prior to initiating antiretroviral therapy.
Innovative projects and programmes for the strategic development of the municipality

The relevance of the matter is caused by the fact that the essence of strategic planning consists in the definition of the priority sphere of social-and-economic development of the city district taking into account the external environment factors and available resources. It is necessary to prove the organization of the chosen project or programme, including sources and mechanisms of resources attraction, applied technologies, technical means, etc. within strategic management. The main document in the sphere of complex social-and-economic development of the municipal unit is the strategic plan that allows formulating the perspective purposes of the development, choosing alternative options of the municipality, thereby attracting investments into the projects and programmes. The subject of the research is the “City district Podolsk”. Some problems of strategic planning of investment projects and programmes, which are necessary for the improvement of activity of the “city district Podolsk”, are studied. The objective of the research is to develop recommendations on the strategic planning of activity of the “City district Podolsk”. Calculations for three investment programmes are made for the identification of the most successful direction of strategic development of the “City district Podolsk” by the means of formulas of the indicator of efficiency and coefficient of competitiveness. The achieved results can be used for creation of the Draft of the strategic development plan for the “City district Podolsk” till 2022.
An experiment design: investigating VR locomotion & virtual object interaction mechanics

In this paper, we describe an experiment outline on investigating design and user experience related aspects of several virtual reality locomotion and virtual object interaction mechanics. These mechanics will be based on consumer hardware like a common game controllers, an infrared hand and finger tracking device, VR hand controllers and an omnidirectional treadmill. Corresponding related work will contextualize and motivate this research. The projected experimental study will be based on user test sessions with a specifically developed 1st person VR puzzle horror game, called Gooze. A hybrid approach of self-assessment, in-game parameter tracking and session observations will be proposed for the investigation. Statistical analysis methods will be suggested to evaluate results. Furthermore, this paper will give an overview of the game and elaborate on design, gameplay and user experience related insights of already conducted informal pre-studies with it.
Migraine: Diagnosis and assessment of disability

Migraine is a heterogeneous disorder characterized by attacks that vary in frequency, duration, severity and symptomatology. Migraine sufferers experience reduced health-related quality of life in comparison with the general population. Almost half of all sufferers have moderate to severe disability, with one-third having severe disability or needing bed rest. However, migraine is underdiagnosed and undertreated. A clinical tool that grades migraine sufferers according to their illness severity has the potential to improve migraine care by aiding communication between patients and healthcare professionals, and by providing a means to match level of medical care with disease severity. The Migraine Disability Assessment (MIDAS) Questionnaire is such a clinical too I. MIDAS is scored by summing five items that cover days of missed activities and reduced productivity in defined roles. MIDAS exhibits high internal consistency, test-retest reliability, accuracy, and face validity and corresponds to physicians' judgements of illness severity and medical need. These features support the use of MIDAS in research and clinical practice. To improve healthcare delivery for migraine, disabled migraine sufferers should be encouraged to seek medical care and effectively communicate about their illness. In turn, physicians should be encouraged to make specific diagnoses, assess disability and select treatments appropriate to diagnosis and disability. The MIDAS Questionnaire can play an important role in public health initiatives for migraine.
Category of $H$-groups

‎This paper develops a basic theory of $H$-groups‎. ‎We‎ ‎introduce a special quotient of $H$-groups and‎ ‎extend some algebraic constructions of topological groups to the category‎ ‎of H-groups and H-maps and then present a functor from this category to the category of quasitopological groups‎.
Automated methods for ischemia detection in long-duration ECGs

Myocardial ischemia diagnosis using long-duration electrocardiographic recordings is a simple and noninvasive method that needs further development before being used in everyday medical practice. Several techniques that automate ischemia detection have been proposed during the last decade and are under evaluation. They are based on different methodologic approaches, which include digital signal analysis, rule-based techniques, fuzzy logic methods, and artificial neural networks, with each approach exhibiting its own advantages and disadvantages. Most recent systems employ artificial neural networks to perform diagnoses since they have demonstrated great consistency in producing accurate results. The performance of the developed detection systems is very promising but they need further evaluation.
Predicting Depression Tendency based on Image, Text and Behavior Data from Instagram

Depression is common but serious mental disorder. It is classified as a mood disorder, which means that it is characterized by negative thoughts and emotions. With the development of Internet technology, more and more people post their life story and express their emotion on social media. Social media can provide a way to characterize and predict depression. It has been widely utilized by researchers to study mental health issues. However, most of the existing studies focus on textual data from social media. Few studies consider both text and image data. In this study, we aim to predict one’s depression tendency by analyzing image, text and behavior of his/her postings on Instagram. An effective mechanism is first employed to collect depressive and non-depressive user accounts. Next, three sets of features are extracted from image, text and behavior data to build the predictive deep learning model. We examine the potential for leveraging social media postings in understanding depression. Our experiment results demonstrate that the proposed model recognizes users who have depression tendency with an F-1 score of 82.3%. We are currently developing a tool based on this study for screening and detecting depression in an early stage.
Level of Awareness and Extent of Utilization of the Ten Medicinal Plants Approved by the Department of Health

The study aimed to determine the level of awareness and extent of utilization of the ten medicinal plants approved by the DOH. It also delved into the problems experienced by the selected residents in the utilization of medicinal plants. There were ten respondents included because they qualified in the inclusion criteria as having 3-5 medicinal plants in their environment and non-working mothers. The study was conducted in Sitio Sili-Sili, Barangay Pagatpat. The respondentsâ€™ sources of information on the DOH approved medicinal plants were the traditional healers, family members and relatives, BHWs, students and neighbors. The parts of the medicinal plants used in the preparation are fresh leaves, garlic cloves, and fruit. The methods of preparation were pounding / crashing of fresh leaves and garlic cloves, boiling of leaves, soaking in a glass of water, slicing of garlic cloves, and heating of leaves. The methods of application were oral / drinking, rubbing to the affected area of the body, and washing the affected area. The duration of ranged from short durations 2 days to 2 months and the longer duration covered 3 months to one year. The respondentsâ€™ level of awareness of the medicinal plants approved by the DOH accounted to sixty percent as they are aware of the indication, dosage, and preparation of six plants, such as akapulko, ampalaya, bawang, bayabas, lagundi, and sambong. They are not aware of the other four medicinal plants. They utilized the medicinal plants which they are aware of four specific common diseases/ailments which they experienced. However, they are also utilizing other medicinal plants, such as ABC, kalabo, atay-atay, and tawa-tawa. This scenario led them to be worried because they found these plants effective in treating common ailments, but consequently, they felt a need for further awareness and knowledge of the other medicinal plants which they are not aware of. Â Keywords - Medicinal Plants, Awareness, Utilization, Approved by the DOH
OPIOID-CANNABINOID CODRUGS WITH ENHANCED ANALGESIC AND PHARMACOKINETIC PROFILE

OF DISSERTATION Harpreet Kaur Dhooper College of Arts & Sciences University of Kentucky 2010 OPIOID-CANNABINOID CODRUGS WITH ENHANCED ANALGESIC AND PHARMACOKINETIC PROFILE _________________________________________ ABSTRACT OF DISSERTATION _________________________________________ A dissertation submitted in partial fulfillment of the requirement for the degree of Doctor of Philosophy in the College of Arts & Sciences at the University of Kentucky By Harpreet Kaur Dhooper Lexington, Kentucky Director: Dr. Peter A. Crooks, Professor of Pharmaceutical Sciences Lexington, Kentucky 2010 Copyright © Harpreet Dhooper 2010 ABSTRACT OF DISSERTATIONOF DISSERTATION OPIOID-CANNABINOID CODRUGS WITH ENHANCED ANALGESIC AND PHARMACOKINETIC PROFILE The central hypothesis of the dissertation is that “the design and synthesis of a codrug of an opiate and a cannabinoid can be achieved which is stable in the gastrointestinal tract and shows a superior pharmacological and pharmacokinetic profile when compared to a physical mixture of the two parent drugs. ” To prove the hypothesis, a series of novel codrugs were prepared by conjugation of the opiate drug codeine with ∆tetrahydrocannabinol (∆-THC), cannabidiol, abn-cannabidiol and an opiate prodrug 3-Oacetylmorphine with ∆-THC. Codeine-cannabinoid codrugs were evaluated for analgesic activity in the rat after oral administration. The Cod-THC codrug showed greater effectiveness as well as prolonged pain management properties as compared to the parent drugs. The stability of Cod-THC codrug in aqueous solutions from pH 1-9, in simulated gastrointestinal fluids, in brain homogenate and the hydrolysis of the carbonate ester linkage in rat plasma suggested that after oral administration, the codrug would be absorbed intact from the GI tract and then hydrolyze in the plasma to generate both parent drugs. The enzymes present in rat brain homogenate were incapable of cleaving the codrug into the parent drugs. The pharmacokinetic profiles of the Cod-THC codrug and an equimolar physical mixture of the parent drugs were evaluated in rats. The plasma concentrations of codeine and ∆ THC were much higher after codrug administration compared to the plasma concentrations of these drugs after oral administration of an equimolar physical mixture. The parent drugs were also present in the plasma for longer period of time compared to the physical mixture, probably due to the sustained release of the parent drugs from codrug in the plasma. The concentrations of codeine and Δ-THC were much higher in rat brain after oral administration of the Cod-THC codrug as compared to brain concentrations of these drugs after oral administration of the physical mixture. Thus, the design and synthesis of an opiate and a cannabinoid codrug was achieved which was stable in the gastrointestinal tract, showed enhanced analgesic effects as compared to the parent drugs, and also showed a superior pharmacokinetic profile when compared to a physical mixture or the two parent drugs.
Exploiting Meta-Path with Attention Mechanism for Fine-Grained User Location Prediction in LBSNs

Based on the huge volumes of user check-in data in LBSNs, users’ intrinsic mobility patterns can be well explored, which is fundamental for predicting where a user will visit next given his/her historical check-in records. As there are various types of nodes and interactions in LBSNs, they can be treated as Heterogeneous Information Network (HIN) where multiple semantic meta-paths can be extracted. Inspired by the recent success of meta-path context based embedding techniques in HIN, in this paper, we design a deep neural network framework leveraging various meta-path contexts for fine-grained user location prediction. Experimental results based on two real-world LBSN datasets demonstrate the best effectiveness of the proposed approach using various evaluation metrics than others.
Formulation and Evaluation of Topical Liposomal Gel for Fluconazole

Liposomal carriers, well known for their potential in topical drug delivery have been choosen to help fluconazole molecules in the skin layers. In the present work statistical study for the formulation of liposomes for topical delivery of fluconazole using the factorial design approach was undertaken. Amount of phospholipid (PL 90H) and cholesterol (CH) were taken at three different levels and liposomes were prepared using film hydration technique. Gels containing liposomes (optimized batch) were prepared in Carbopol® 934 NF and were characterized for rheology, spreadability, permeation and drug deposition in the rat skin. Results of regression analysis revealed that vesicle size and entrapment efficiency were dependant on the cholesterol and lipid concentration. Rheological studies of all liposomal gels prepared with 1%, 1.5%, and 2% w/w carbopol gave a clear idea of concentration of carbopol required. Liposomal dispersion and gels were found to increase the skin permeation and deposition compared to control and marketed gel. Liposome dispersion and gel formulation were found to be stable for 60 days.
The causes of the inflammation and possible therapeutic options in dialysis patients

Cardiovascular morbidity and mortality are increased in patients with chronic kidney disease and especially dialysis. In patients with uremia, inflammation starts long before renal replacement therapy. Besides the other important parameters such as malnutrition and atherosclerosis, inflammation is one of the most important causes of morbidity and mortality in uremic patients. An association between cardiovascular mortality and morbidity and inflammation in both chronic kidney disease and dialysis patients has been demonstrated by a lot of studies in the past. Inflammation in patients with renal failure who have not yet begun dialysis and in patients receiving dialysis has shown increased levels of inflammatory markers, such as Creactive protein, interleukin-6, tumor necrosis factoralpha. In this review, it is tried to discuss both possible causes of inflammation and possible therapeutic strategies in dialysis patients.
Maximum surgical blood order schedule reduces hospital costs.

Abstract The maximum surgical blood order schedule (MSBOS) is a viable option for reducing unnecessary crossmatching and achieving significant cost savings in the blood bank. A MSBOS specifies, and thus limits, the amount of blood normally crossmatched for elective surgical procedures. During the first 10 months after introducing MSBOS at our hospital, there was a 33 per cent drop in the number of units of blood crossmatched for elective surgical procedures. The 712 crossmatches that were avoided saved the hospital blood bank more than $6000. Patient care was not adversely affected. Institution of MSBOS can be accomplished without difficulty by gaining input from surgeons and anesthesiologists. After implementation, follow-up is advisable to attain optimal blood use.