Miracle-dz/UniFAR-FTUs huggingface dataset:
A Review on the Fate of Legacy and Alternative Antimicrobials and Their Metabolites during Wastewater and Sludge Treatment

Antimicrobial compounds are used in a broad range of personal care, consumer and healthcare products and are frequently encountered in modern life. The use of these compounds is being reexamined as their safety, effectiveness and necessity are increasingly being questioned by regulators and consumers alike. Wastewater often contains significant amounts of these chemicals, much of which ends up being released into the environment as existing wastewater and sludge treatment processes are simply not designed to treat many of these contaminants. Furthermore, many biotic and abiotic processes during wastewater treatment can generate significant quantities of potentially toxic and persistent antimicrobial metabolites and byproducts, many of which may be even more concerning than their parent antimicrobials. This review article explores the occurrence and fate of two of the most common legacy antimicrobials, triclosan and triclocarban, their metabolites/byproducts during wastewater and sludge treatment and their potential impacts on the environment. This article also explores the fate and transformation of emerging alternative antimicrobials and addresses some of the growing concerns regarding these compounds. This is becoming increasingly important as consumers and regulators alike shift away from legacy antimicrobials to alternative chemicals which may have similar environmental and human health concerns.
Curry leaf (Murraya koenigii L. Spreng) as a functional food.

Use of Indian spices in preventive and therapeutic medicine is being practiced in India since times immemorial. Curry leaves ( Murraya koenigii ) is a leafy spice used in Indian cookery for its fragrant aroma. Curry leaves are rich in fibres, minerals and vitamins such as calcium, iron, phosphorus and carotene, niacin, vitamin B 2 and vitamin C. Traditionally curry leaves are used in the treatment of various diseases which includes Diabetes mellitus, body pain, inflammation, and vomiting and kidney pain, blood disorders and in treatment of poisonous bites. The functional compounds of curry leaves includes oxalic acid, vitamin A, bicyclomahanimbicine, cyclomahanimbine, murrayastine, coumarine, koenidine and pypayafolinecarbazole Bioactive compounds of curry leaves like carbazole alkaloids and essential oils are proven to have many functional properties like antioxidant, antimicrobial, antitumor, antidiabetic, hypercholesteremic and many more. Curry leaves are used in Indian dishes in different forms, such as, fresh, dried and powdered. Dehydration is the most feasible way of preservation of curry leaves. Methods of preservation and techniques of dehydration affects the nutrient composition. The present review summarizes studies on the nutraceutical potential, nutritional composition and effect of processing on the bioactive compounds of curry leaves.
Whole-exome sequencing reveals novel vacuolar ATPase genes' variants and variants in genes involved in lysosomal biology and autophagosomal formation in oral granular cell tumors.

BACKGROUND Granular cell tumors (GCTs) are rare neuroectodermal soft tissue neoplasms that mainly affect the skin of the upper limbs and trunks and the oral cavity. GCTs are derived from Schwann cells and, ultrastructurally, their intracytoplasmic granules are considered autophagosomes or autophagolysosomes and are consistent with myelin accumulation. METHODS In this study, a convenience set of 22 formalin-fixed, paraffin-embedded samples of oral GCTs, all but one sample located at the tongue, was screened for mutations by whole-exome sequencing. RESULTS Two novel variants in genes of the vacuolar ATPase (V-ATPase) complex: ATP6AP1 frameshift c. 746_749del, leading to p.P249Hfs*4, and ATP6V1A nonsynonymous c.G868A, leading to p.D290N. Each of these mutations occurred in one case. With regard to the samples that were wild-type for these V-ATPase variants, at least two samples presented variants in genes that are part of endosomal/lysosomal/autophagosomal networks including ABCA8, ABCC6, AGAP3, ATG9A, CTSB, DNAJC13, GALC, NPC1, SLC15A3, SLC31A2 and TMEM104. CONCLUSION Although the mechanisms involved in oral GCT initiation and progression remains unclear, our results suggest that oral GCTs have V-ATPase variants similarly to GCTs from other tissues/organs, and additionally show variants in lysosomes/endosomes/autophagosomal genes.
Polyethylene-Carbon Composite (Velostat®) Based Tactile Sensor

The progress observed in ‘soft robotics’ brought some promising research in flexible tactile, pressure and force sensors, which can be based on polymeric composite materials. Therefore, in this paper, we intend to evaluate the characteristics of a force-sensitive material—polyethylene-carbon composite (Velostat®) by implementing this material into the design of the flexible tactile sensor. We have explored several possibilities to measure the electrical signal and assessed the mechanical and time-dependent properties of this tactile sensor. The response of the sensor was evaluated by performing tests in static, long-term load and cyclic modes. Experimental results of loading cycle measurements revealed the hysteresis and nonlinear properties of the sensor. The transverse resolution of the sensor was defined by measuring the response of the sensor at different distances from the loaded point. Obtained dependencies of the sensor’s sensitivity, hysteresis, response time, transversal resolution and deformation on applied compressive force promise a practical possibility to use the polyethylene-carbon composite as a sensitive material for sensors with a single electrode pair or its matrix. The results received from experimental research have defined the area of the possible implementation of the sensor based on a composite material—Velostat®.
Interaction between the place of residence and wealth on the risk of overweight and obesity in Bangladeshi women

Background The prevalence of overweight and obesity in women has increased significantly over the last few decades in Bangladesh, a rapidly urbanising developing country. However, little is known regarding the association between the interaction of the place of residence and household wealth with overweight and obesity, particularly in women from developing countries. Objective The objective of this study is to find the association between the interaction of the place of residence and wealth with overweight and obesity among Bangladeshi women. Methods This study utilised data from the four Bangladesh Demographic Health Surveys conducted in 2004, 2007, 2011 and 2014 with a total of 54337 women aged 15–49 years. Multivariate logistic regression was used for the analyses. Results The prevalence of overweight and obesity among women aged 15–49 years in Bangladesh has considerably increased from 9.96% in 2004 to 24.43% in 2014. The interaction between wealth and place of residence has been found to be associated with obesity. Urban wealthy and richest women were 4.23 (OR: 4.23, 95% CI: 1.25–14.34) and 5.99 (OR: 5.99, 95% CI: 1.91–18.74) times more likely to be obese compared to their rural counterparts in the period 2004. Urban richest were 2.94 times (OR: 2.94, 95% CI: 1.20–7.24) more likely to be obese against their rural counterparts for the survey year 2014. Conclusions The place of residence is not associated with obesity, but its interaction with wealth is significant.
Acclimation to warm temperatures has important implications for mitochondrial function in Atlantic salmon (Salmo salar)

ABSTRACT In fish, the capacity of thermal acclimation to preserve cardiac mitochondrial function under future warming scenarios is important to understand given the central roles that cardiac energy metabolism and performance play in this taxa's thermal tolerance. We acclimated Atlantic salmon to 12 and 20°C (for >2 months), and investigated the effects of acute and chronic warming on cardiac mitochondrial respiration and reactive oxygen species (ROS) production (release rate) using high-resolution fluorespirometry. Further, we compared the sensitivity of mitochondrial respiration to nitric oxide (i.e. the NO IC50), and assessed the mitochondrial response to anoxia–reoxygenation (AR). Acute exposure to 20°C increased maximal mitochondrial respiration by ∼55%; however, the mitochondria's complex I respiratory control ratio was 17% lower and ROS production was increased by ≥60%. Acclimation to 20°C: (1) preserved mitochondrial coupling and aerobic capacity; (2) decreased the mitochondria's ROS production by ∼30%; (3) increased the mitochondria's NO IC50 by ∼23%; and (4) improved mitochondrial membrane integrity at 20°C. AR did not affect mitochondrial function at 12°C, but acute exposure to 20°C and AR depressed maximal mitochondrial respiration (by ∼9%) and coupling (by ∼16%) without impacting ROS production. Finally, warm acclimation did not improve the capacity of mitochondria to recover from AR, indicating that there was no ‘cross-tolerance’ between these challenges. Our findings provide compelling evidence that thermal plasticity of cardiac mitochondrial function contributes to the Atlantic salmon's capability to survive at ≥20°C for prolonged periods, but call into question whether this plasticity may allow them to withstand high temperatures when combined with other stressors. Summary: Maximal respiration in Atlantic salmon is increased similarly by acute and chronic warming. Warm acclimation preserves complex I coupling, mitigates ROS production and decreases the sensitivity of mitochondrial respiration to nitric oxide.
Polymorphisms of the IL-17A Gene Influence Milk Production Traits and Somatic Cell Score in Chinese Holstein Cows

The cow’s milk production characteristics are a significant economic indicator in the livestock industry. Serum cytokines such as interleukin-17 (IL-17) may be potential indicators for bovine mastitis concerning the milk somatic cell count (SCC) and somatic cell score (SCS). The current study aims to find previously undiscovered single nucleotide polymorphisms in the bovine (IL-17A) gene and further investigates their associations with milk production traits in Chinese Holstein cows. Twenty Chinese Holstein cows were randomly chosen from six farms in Jiangsu Province, China. The DNA was extracted from selected samples of bloods for PCR amplification Sequence analyses were used to find SNPs in the bovine (IL-17A) gene. The discovered five SNPs are g-1578A>G, g-1835G>A, and g-398T>A in the 5′UTR; g3164T>C and g3409G>C in the exon region. The genotyping of Holstein cows (n = 992) was performed based on Sequenom Mass ARRAY and SNP data. The connection between SNPs, milk production variables, and the somatic cell score was investigated using the least-squares method. Based on the results, SNP g-398T>A had a significant linkage disequilibrium with g3164T>C. SNPs were found to have significant (p < 0.05) correlations with the test-day milk yield. In conclusion, IL-17A affects cow’s milk production traits significantly.
Examining Proposed Changes to the Conceptualization of the Alexithymia Construct: The Way Forward Tilts to the Past

Fifty years ago, Psychotherapy and Psychosomatics published an article by John Nemiah and Peter Sifneos [1] in which they reported some clinical observations on the mentation of a group of patients with “classic” psychosomatic diseases. This article, together with a book chapter published in the same year [2], heralded the soon to be introduced concept of alexithymia [3], which encompassed the cognitive characteristics that Nemiah and Sifneos had reported. The concept was not entirely new, which Nemiah and Sifneos readily acknowledged, and they noted that Ruesch [4] had described some of the same characteristics in the late 1940s; in addition, the cognitive style resembled the operational thinking (pensée opératoire) that Marty and de M’Uzan [5] had observed among somatically ill patients in France. As a theoretical concept, alexithymia quickly captured the interest of psychosomatic medicine specialists and was chosen as the main theme of the 11th European Conference on Psychosomatic Research held in Heidelberg in 1976 [6]. Though there were some critics of the concept, the majority of conference delegates agreed that alexithymia should be conceptualized as a hypothetical multifaceted construct that could be operationalized and evaluated empirically. On the final day of the conference, Sifneos [7] confidently predicted that “alexithymia is here to stay whether we like it or not and it is going to be with us for the rest of our lives” (p. 369). He recommended that a scientific approach be taken to further investigate the construct. Half a century since the publication of Nemiah and Sifneos’s initial report, it seems timely to evaluate Sifneos’s prediction and recommendation, particularly because several alexithymia researchers have proposed various changes to the manner in which the construct was originally conceptualized and defined. These changes include adding an emotionalizing component to the alexithymia construct, removing the restricted imaginal activity facet, dividing alexithymia into categorically distinct subtypes, renaming severe degrees of alexithymia as “affective agnosia,” reconceptualizing the construct within the framework of an attention-appraisal model, and theorizing alexithymia as a general deficit in interoception. These proposals raise a number of intriguing questions about the nature of alexithymia and present perspectives that we believe drift from the original observations of “psychosomatic” patients, which directly informed the theoretical parameters of the construct. In this editorial, we consider these various perspectives and evaluate each of the proposed changes from both a
Associations between Health-Related Physical Fitness and Cardiovascular Disease Risk Factors in Overweight and Obese University Staff

Purpose: This cross-sectional study examined the associations between health-related physical fitness (HPF) and cardiovascular disease (CVD) risk factors in overweight and obese university staff. Methods: A total of 340 university staff (109 women, mean age 43.1 ± 9.7 years) with overweight (n = 284) and obesity (n = 56) were included. The HPF indicators included skeletal muscle mass index (SMI), body fat percentage (BFP), grip strength (GS), sit-and-reach test (SRT), and vital capacity index (VCI). CVD risk factors were measured, including uric acid (UA), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and glucose (GLU). Results: BFP, SMI, and GS were positively associated with UA level (β = 0.239, β = 0.159, β = 0.139, p < 0.05). BFP was positively associated with TG and TG/HDL-C levels (β = 0.421, β = 0.259, p < 0.05). GS was positively associated with HDL-C level (β = 0.244, p < 0.05). SRT was negatively associated with GLU level (β = −0.130, p < 0.05). Conclusions: In overweight and obese university staff, body composition, muscle strength, and flexibility were associated with CVD risk factors. An HPF test may be a practical nonmedical method to assess CVD risk.
Ion implantation into amorphous Si layers to form carrier‐selective contacts for Si solar cells

This paper reports our findings on the boron and phosphorus doping of very thin amorphous silicon layers by low energy ion implantation. These doped layers are implemented into a so‐called tunnel oxide passivated contact structure for Si solar cells. They act as carrier‐selective contacts and, thereby, lead to a significant reduction of the cell's recombination current. In this paper we address the influence of ion energy and ion dose in conjunction with the obligatory high‐temperature anneal needed for the realization of the passivation quality of the carrier‐selective contacts. The good results on the phosphorus‐doped (implied Voc = 725 mV) and boron‐doped passivated contacts (iVoc = 694 mV) open a promising route to a simplified interdigitated back contact (IBC) solar cell featuring passivated contacts. (© 2014 WILEY‐VCH Verlag GmbH &Co. KGaA, Weinheim)
Serum Calcium and 25-Hydroxy Vitamin D Level in Normal and Early Onset Pre-eclamptic Pregnant Women

of LOPE are higher than EOPE, the outcomes are worse in EOPE in terms of lower gestational age delivery, lower birthweight, lower 5-minutes APGAR score, higher incidence of stillbirth, early neonatal death, and perinatal mortality the pathogenesis of EOPE is fully elucidated. theory for the pathogenesis of Pre-eclampsia two-staged model, where poorly perfused placenta due to the failure in placental vascular remodelling 1) the clinical manifestations of EOPE (Stage are several factors that have been to be involved in the failure in placental vascular remodelling, which are maternal constitutional factors, genetic, behavioural, environmental and nutrition modified by the physiological changes of pregnancy the pathogenesis of LOPE is associated with maternal factors. Among all maternal factors that may contribute to the LOPE, pre-pregnancy to play a crucial role Considering that the outcomes are more severe in EOPE than in LOPE, this study focused on the factors that contribute to the incidence of EOPE. this of ABSTRACT Introduction: Pre-eclampsia is one of the most common causes of fetomaternal morbidity and mortality worldwide. This disorder is categorised into Early Onset Pre-eclampsia (EOPE) and Late-Onset Pre-eclampsia (LOPE). EOPE is usually accompanied by severe complications for both the mother and fetus, while LOPE is accompanied by relatively mild fetomaternal complications. Although the pathogenesis of EOPE is not yet fully elucidated, recent studies indicate that serum calcium and 25 Hydroxy Vitamin D (25(OH)D) levels may play a role in its pathogenesis. Aim: To find out the relationship of calcium and 25(OH)D serum levels in pregnant women with normal pregnancy and with EOPE in Indonesia. Materials and Methods: This study was a case-control study, conducted in Dr. Soetomo General Hospital from July to October 2017. A total of 36 women with EOPE and 64 women with normal pregnancy were included in this study. Inclusion criteria were pregnant women in 2 nd or 3 rd -trimester with BMI >18 kg/m 2 . Blood sample analysis was done to measure serum calcium and 25(OH)D level. Data were expressed as Mean±Standard Deviation. Data distribution was analysed using Shappiro-Wilk test. Comparison of serum calcium and 25(OH)D level between groups was analysed using Independent t-test. Correlation between serum calcium and 25(OH)D level was analysed using Pearson’s correlation test. The p-value of <0.05 was considered significant. Results: There was a significant difference in serum calcium level between case and control group (8.294±0.725 vs 8.670±0.405 mg/dL; p=0.006). In 25(OH)D level, there was no difference between both groups (16.128±7.5463 vs 17.325±6.4992 ng/ mL; p=0.406). No correlation was found between calcium and 25(OH)D level (r=0.165; p=0.101). Conclusion: Calcium deficiency plays a role in the incidence of
Beliefs About Medicine and Glycemic Control Among Type 2 Diabetes Patients: A Cross-Sectional Study in West Bank, Palestine

Introduction: To examine the mean differences between patient beliefs about medicine with reference to adherence and glycemic control. Methods: This study utilized a cross-sectional questionnaire-based approach. Adherence to medication was measured with the Morisky Green Levine Medication Adherence Scale (MGLS); glycemic control as the last HbA1c test value; and beliefs about medicine with the Beliefs about Medicines Questionnaire (BMQ). Results: According to MGLS scale, 220 (57.9%) of the diabetic patients were classified as high adherent to their medications and 160 (42.1%) were classified as low adherent. Patients had strong believes in their medication, the mean necessity score was significantly outweighed the mean concerns score (17.7 vs 14.4; P < .001). Low adherent patients had significantly more concerns about long term effect of medications (14.4 vs 13.8; P < .008). No significant mean differences were found between glycemic controlled and uncontrolled group regarding necessity or concern domains. Conclusion: Assessing beliefs about medicine is crucial for recognizing patients at risk of low adherence, which offers a way to help patients with diabetes to achieve a better glycemic control.
BACTERIOLOGICAL ASSESSMENT FOR CLEANING AND SANITIZING OF DOMESTIC MILKING EQUIPMENT BY USING OZONATED WATER

A total of 20 raw milk samples were used as the fouling agent for evaluating the bacteriological effectiveness of cleaning and sanitizing of domestic milking equipment by using ozonated water at 0.5 ppm comparing to the warm water at 55! for 5 minutes respectively. The mean values of total aerobic bacteria, Coliform and E.coli that present on the plastic and stainless-steel containers after using the raw milk as fouling agent were 3.4×10-6 , 6.7x10-5 and 5.8×10-3 cfu/cm2 respectively , after cleaning the stainless steel containers by the ozonated water the mean values of total aerobic bacterial counts, Coliforms and E.coli bacteria were reduced to 1.2×10-6, 4.7×10-5 and 3.3×10-3 CFU/cm2 respectively. while after cleaning by the warm water were only reduced to 2.3x10-6, 2.7×10-5and 2.8×10-3 CFU/cm2 respectively . The mean values of total aerobic bacteria, coliform ,and E.coli counts/ cm2 after cleaning the plastic containers by the ozonated water were reduced to 1.4×10-6, 1.8×10-5 and 2.4×103 CFU/cm2 respectively, while the mean values after cleaning by the warm water were reduced to 1.1×10-6, 1.7×10-5 and 2.3×103 CFU/cm2 respectively . The mean values of total aerobic, Coliforms and E.coli bacteria after using both the Ozonating and warm water for both stainless steel and plastic containers were reduced to 4.2x10-5, 2.1x10-3, 1.6x10-2, 2.2x10-5, 5.1x10-3 and 1.4x10-2 CFU/cm2 respectively. The results of the current study showed that the independed either treatment by the ozonated or warm water not effectively reduced the number of the quality control bacteria because such reduction in bacterial population could not be enough to guarantee the safety of the home dairy containers, while the combined both treatments had a significant reduction in the population of the quality control bacteria. The effectiveness of cleaning and sanitization by the ozonated and warm water process may be depending on the initial count contaminated bacteria of raw milk, exposure time, kind of containers and both concentration of ozone and the heating temperature.
Toward Enabled Industrial Verticals in 5G: A Survey on MEC-Based Approaches to Provisioning and Flexibility

The increasing number of heterogeneous devices connected to the Internet, together with tight 5G requirements have generated new challenges for designing network infrastructures. Industrial verticals such as automotive, smart city and eHealthcare (among others) need secure, low latency and reliable communications. To meet these stringent requirements, computing resources have to be moved closer to the user, from the core to the edge of the network. In this context, ETSI standardized Multi-Access Edge Computing (MEC). However, due to the cost of resources, MEC provisioning has to be carefully designed and evaluated. This survey firstly overviews standards, with particular emphasis on 5G and virtualization of network functions, then it addresses flexibility of MEC smart resource deployment and its migration capabilities. This survey explores how the MEC is used and how it will enable industrial verticals.
A comparison between several approaches of piezoelectric energy harvesting

This paper compares the performances of vibration-powered electrical generators using a piezoelectric ceramic and a piezoelectric single crystal associated to several power conditioning interfaces. A new approach of the piezoelectric power conversion based on a non linear voltage processing is presented, leading to three novel high-performance techniques. Theoretical predictions and experimental results show that the novel techniques may increase the power harvested above 800% compared to standard techniques.