Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimation of hearing impairment occurrence in patients with Lyme borreliosis – preliminary study

Borelioza z Lyme (Lyme borreliosis – LB) jest najczęstszą chorobą odkleszczową u ludzi. Celem pracy było przeprowadzenie wstępnej analizy występowania zaburzeń słuchu u chorych na LB.Testy audiometryczne objęły 66 chorych z rozpoznaną LB, w wieku od 18 do 45 lat. Wszyscy badani (kobiety i mężczyźni) zostali podzieleni na dwie główne grupy: 1 – wczesnej, rozsianej LB i 2 – późnej LB; wśród nich zostały wyodrębnione podgrupy pacjentów z rozpoznaniem neuroboreliozy (Lyme neuroborreliosis – LNB). Diagnostykę narządu słuchu przeprowadzono na podstawie badań audiometrii tonalnej, audiometrii tonalnej rozszerzonej (o wysokiej częstotliwości do 18 kHz), audiometrii impedancyjnej i audiometrii mowy. Nieprawidłowe wyniki testów audiometrycznych stwierdzono u 66,7% badanych, a analiza statystyczna wskazała na istotny związek z zakażeniem Borrelia burgdorferi (p = 0,017). Większość stanowiły osoby z późną LB, zarówno bez, jak i z LNB.Zaburzenia słuchu różnego stopnia występują u ponad połowy chorych na LB, zwłaszcza w późnych stadiach procesu chorobowego. Uzyskane wyniki wskazują na konieczność prowadzenia dalszych wszechstronnych badań uwzględniających uszkodzenie narządu słuchu i równowagi w przebiegu LB, obejmujących większe grupy chorych.
Indications, applications, and limits of NBI® technology in the diagnosis and follow-up of laryngeal cancer

Many authors have shown how NBI® plays different roles in the management of laryngeal cancer [1] during preoperative diagnostic work up, in the intra-operative setting, and during post-treatment (i.e., surgery, radiotherapy or chemo- radiotherapy) follow-up. The most relevant limitation of NBI® is certainly the possibility of generating, at least in the early phase of the learning curve, an increased number of false positives with consequently unjustified biopsies. Introduction of the NBI® system to routine laryngological practice may drastically change diagnostic strategies for early detection of carcinomas in laryngeal lesions and may lead to minimally invasive treatment of laryngeal diseases at an earlier stage than is presently possible.
Endoskopische Resektionsverfahren EMR und ESD – Schritt für Schritt

Probst A us tim m un g de s V er la ge s. Prämaligne oder frühe maligne Läsionen des Gastrointestinaltrakts können endoskopisch entfernt werden – und diese organerhaltende Therapie bietet eine erheblich bessere Lebensqualität für die Patienten als eine Organresektion. Verschiedene Verfahren stehen zur Verfügung: Grundsätzlich unterschieden werden die endoskopische Mukosaresektion (EMR) und die endoskopische Submukosadissektion (ESD), die in diesem Beitrag detailliert dargestellt werden.
Lethal and atypical fetopathy caused by cytomegalovirus recurrence with isolated intra-abdominal complication in an immune woman

A pregnant woman did not show any problem during the first trimester, but ultrasound exam, confirmed by RMI, showed a large intra-abdominal hyper-echogenic cystic image at 24 weeks of gestation. Meconial peritonitis was suspected, complicated by stable splenomegaly. No neurological signs, variation of the amniotic fluid volume, cardiologic dysfunction or thrombocytemia was observed. Serological assays done before and during pregnancy showed constant low IgM and high IgG antiCMV levels. Amniocentesis showed a high viral load in amniotic fluid. Fetal and maternal bleed were positive. The pregnancy was interrupted at 31 weeks without post-mortem fetal examination. Placenta revealed hydrophic villi with cytomegalic anti-CMV positive inclusions. This case of CMV recurrence leads to severe complications of the fetal development in a pregnant woman. The isolated abdominal abnormalities were an atypical presentation of fetal CMV, causing inappropriate decisions. Multiplex examinations on amniotic fluid would be keys during the pregnancy examination to prevent fatal outcomes. *Correspondence to: Maxime Pichon, Department of Virology, Infectious Agents Institute, 103 grande rue de la Croix Rousse, 69003 Lyon, France, Tel: +33(0)472071022 ; E-mail: maxime.pichon01@chu-lyon.fr
Glucose Homeostasis and Insulin Resistance in veal calves: Studies on the effects of age, nutritional modulations and the applicability of metabolic profiling techniques

Insuline resistentie, een risicofactor voor het ontwikkelen van type 2 diabetes, komt niet alleen vaak voor bij mensen, maar ook bij dieren. Vleeskalveren ontwikkelen vaak insuline resistentie en kunnen als model gebruikt worden om deze pathologie te bestuderen. Het voorkomen van insuline resistentie bij vleeskalveren zou de efficiente benutting van nutrienten (voor groei en gezondheid) kunnen stimuleren. We hebben het effect van leeftijd en verschillende voedingsstrategieen (b.v. spenen, korte-keten fructo-oligosacchariden suppletie, en het deels vervangen de lactose door fructose, glucose, glycerol of vet) op de ontwikkeling van insuline resistentie onderzocht. Uit de resultaten blijkt dat bij kalveren insuline gevoeligheid snel afneemt (vanaf geboorte) en daarna laag blijft. Voedings aanpassingen kunnen leiden tot verbeterde postprandiale glucose homeostase en verminderde glucoseverlies via de urine, maar zal de ontwikkeling van insuline resistentie niet voorkomen. De leeftijdsgerelateerde afname van insuline gevoeligheid in combinatie met de afwezigheid van voedingseffecten suggereert dat de ontwikkeling van insuline resistentie hoofdzakelijk gerelateerd is aan de ontogenetische ontwikkeling van kalveren (de ontwikkeling tot herkauwers). We hebben met behulp van geavanceerde metabolomics technieken verschillende biomarkers en metabole routes ontdekt die mogelijk gerelateerd zijn aan insuline resistentie. Voor de metabole routes van glycerofosfolipiden en sfingolipiden werden verschillende verschillen gevonden. De mechanismen achter de associatie van deze metabole routes met de ontwikkeling van insuline resistentie zijn niet duidelijk. Veranderingen in metabolisme van glycerofosfolipiden in het membraan, bijvoorbeeld, zou de fysisch-chemische eigenschappen van het membraan kunnen beinvloeden en daardoor invloed hebben op de insuline secretie. Het verder toepassen van metabolomics technieken zou de kennis van mogelijke mechanismen achter de ontwikkeling van insuline resistentie kunnen vergroten.
Evaluation of oxidant status in both systolic and diastolic heart failure

Objective: Oxidative stress status in subgroup of heart failure (HF) syndrome still remains unknown. We aimed to study Total Antioxidant Status (TAS), Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) in both systolic and diastolic HF, and also in both ischemic and non-ischemic HF. Materials and Methods: Consecutive 123 chronic HF patients were included in this cross-sectional study. Group 1 consisted of 73 systolic HF patients (50 ischemic patients and 23 non-ischemic patients) and group 2 consisted of 50 diastolic HF patients. As a control group (group 3), 37 healthy subjects were included. Echocardiographic evaluation was performed and TAS, TOS and OSI were studied in all patients. Results: The highest TAS value (1.10±0.24) was found in Group 1, but the lowest in Group 2 (0.90±0.14). Diastolic HF group had the highest TOS value (37.2±10.41) while systolic HF group (32.9±7.26) and control group (26.19±8.00) followed it. OSI was found the highest in diastolic HF group (4.37±1.24) and the lowest in systolic HF group (2.24±0.80). TOS and OSI were similar between ischemic and non-ischemic subgroups of systolic HF but TAS was statistically higher in non-ischemic (p:0.0005). Conclusions: We found higher oxidative stress in HF patients, predominantly in diastolic HF patients. The difference between diastolic and systolic HF with regard to oxidative and antioxidative status seems to come from distinct drugs usage between the groups, which have potential effects on oxidative and antioxidative parameters. To reduce, at least, oxidative stress in diastolic HF patients, medical therapy is needed.
Endoscopic Ultrasound‑Guided Antitumor Therapy for Advanced Pancreatic Cancer

© 2018 Journal of Digestive Endoscopy | Published by Wolters Kluwer Medknow Oncology Group performance status of 0 or 1, age >20 years, and the diagnosis as “progressive disease” after previous chemotherapy based on the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines were studied in this single‐center, nonrandomized, open study of STNM01 (Stelic Institute and Co., Inc., Tokyo, Japan). A 16‐ml STNM01 was administered into the tumor under EUS guidance using a conventional 22‐gauge needle (Expect, Boston Scientific, Japan) at 16 different sites in the tumor (1 ml at each site).
An Evaluation of serum IgE in Atopic patients -predictor for Post-Operative Mesh reaction

1 Associate Professor, Department of General Surgery, Karpagam Faculty of Medical Science and Research, Coimbatore641032, Tamil Nadu, India 2 Assistant Professor, Department of General Surgery, Karpagam Faculty of Medical Science and Research, Coimbatore641032, Tamil Nadu, India 3 Professor, Department of General Surgery, Karpagam Faculty of Medical Science and Research, Coimbatore641032, Tamil Nadu, India 4 Research Associate, Central Research Laboratory, Karpagam Faculty of Medical Science and Research, Coimbatore641032, Tamil Nadu, India Abstract Background: In the modern surgical practice, Hernioplasty remains the commonest surgical procedure in general surgery. Though most of the patient recovers completely without complications, certain number of patients experience a stormy and complicated post-operative period in terms of seroma, infection, pain and last but not the least mesh reaction which is a rare but serious complication. Current day practice involves hernioplasty with polypropylene mesh rather than herniorraphy in most surgical centres, hence every effort should be made to reduce mesh related complications. Mesh reactions are more common in patients with preexisting allergic diseases like atopic dermatitis, asthma, allergic rhinitis, seasonal urticarial and also in patients with elevated serum IgE levels. This retrospective observational study was conducted in patients who underwent open inguinal and ventral hernioplastyfrom March 2010 to Feb 2017 in the Department of General Surgery, Coimbatore medical college hospital, Coimbatore. This study focuses mainly on patients who developed mesh reaction in the post-operative period particularly in patients who have existing atopic manifestations. After analyzing the results of our study, we conclude that IgE antibodies estimation pre-operatively in patients with existing allergic diseases can be used as a predictor for assessing mesh related reactions in the post-operative period. In this continuation we are planning immuno-electrophoresis to pinpoint the gamma globulin associated with mesh reaction.
Management of intraoperative bleeding in Korea

When major bleeding occurs, a surgeon should manage it in a suitable way. The risk of bleeding is minimal when the team members involved have accumulated sufficient relevant experience, have been repeatedly educated on the procedure, and have meticulously reviewed the anatomy. At the time of surgery, proper usage of surgical devices and accurate communication between personnel is also critical to minimizing major bleeding. Minimally invasive surgery (MIS) including robotic surgery has been widely accepted for most thoracic procedures in Korea. We describe our expert experience in dealing with intraoperative bleeding during MIS.
Minimally invasive surgery in vesicoureteric reflux

Vesicoureteric reflux (VUR) is a common condition in children which can cause recurrent urinary tract infection (UTI) and potential renal scarring. Open ureteral reimplantation is the gold standard of operative treatment for many years. With the advance of minimally invasive surgery, endoscopic injection of bulking agents, laparoscopic and robot-assisted laparoscopic ureteral reimplantation (RALUR) were introduced. This has revolutionized whole idea of management of VUR. Here we would like to review the management of VUR and the changes since the minimally invasive era.
Protective role of date fruit extract against chlorpyrifos-induced reproductive toxicity in albino male rats

Introduction: Chlorpyrifos (CPF) is a broad-spectrum organophosphorus insecticide; it causes adverse effects on the male reproductive system. The present study aimed to investigate the protective role of date fruit extract (DFE) on CPF-induced reproductive toxicity in male rats. Materials and Methods: Male rats were treated with CPF (orally with 6 mg/kg bw) or DFE alone (orally with 1000 mg/kg bw) or in combination for 45 days.Body weights, sperm parameters, lipid peroxidation, and levels of antioxidant enzymes were determined. Results: A significant decrease in the weights of testes and epididymis was observed in CPF-treated rats when compared with control rats. Treatment with CPF significantly decreased daily sperm count, epididymal sperm count, sperm motility, and sperm viability. A significant increase in the levels of lipid peroxidation with decreased activity levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) was observed in the testis of CPF-treated rats when compared to control rats, suggesting the CPF-induced oxidative stress in the testes of rats. No changes were observed after administration of DFE alone, whereas coadministration of CPF and DFE showed a significant improvement in body weights and weights of decreased reproductive organs and sperm parameters. Moreover, treatment of DFE to CPF significantly decreased lipid peroxidation with increased antioxidant enzyme levels in the testis compared with CPF-alone-treated rats. Conclusion: The results of the present study concluded that DFE administration protects the CPF-induced reproductive toxicity in male rats.
Student Social Workers' Experiences of Supervision

DOI: https://doi.org/10.32444/IJSW.2018. 79.1. 31-54 Given the managerial and austerity crisis in field practice education in South Africa and internationally, the study explored the perceptions of student social workers regarding their experiences of field practice supervision. A questionnaire-based survey was administered to third-year undergraduate social work students attending a South African university. While most students enjoyed positive supervision experiences a small proportion felt that their supervision was inadequate. Challenges included having supervisors not placed at field instruction agencies; differences between agency supervisors’ expectations and those of the university; and poor quality supervision. Findings highlight the responsibility of universities for the screening, training and support of supervisors, and for university personnel to deal timeously with supervisor-supervisee issues.
Diagnosis of Lower Respiratory Tract Infections using nanopore sequencing

Background: According to WHO, lower respiratory tract infections (LRTI) are the deadliest communicable disease globally, causing 3.2 million deaths annually. Culture is the gold-standard diagnostic, but produces sub-optimal results and takes a minimum of 48hr. Poor diagnostics impact on patient management and treatment. Shotgun-metagenomics can overcome these issues, by reducing turnaround time and improving diagnostic accuracy. Aim: To develop a rapid metagenomics sequencing pipeline for the diagnosis of bacterial LRTIs directly from respiratory samples. Methods: Respiratory samples (sputum and aspirates) from patients with suspected bacterial LRTIs were used to develop and optimise a metagenomics pipeline which included: novel human DNA depletion, pathogen DNA extraction, library preparation and MinION sequencing. Pathogens and antibiotic resistance genes were identified in real-time by MinION sequencing and Epi2ME analysis (Antimicrobial Resistance pipeline) and were compared to clinical microbiology results. Results: The initial sample set (n=42) was 89% concordant with culture for pathogen detection. After optimisation (improving turnaround and sensitivity) the pipeline was tested on a second sample set (n=13) and was 100% concordant with culture. The turnaround time was 6hrs from sample to pathogen and acquired-resistance gene identification. Routine microbiology identified 2 MRSA positive samples, both of which were mecA gene positive using the developed metagenomics sequencing pipeline. Conclusion: LRTI pathogens and antibiotic resistance genes were identified within 6hrs with our pipeline, demonstrating that metagenomic sequencing has the potential to replace culture.
COMPARISON OF ARTERIAL STIFFNESS INDEX AND TPE/QT RATIO IN NORMOTENSIVE, PREHYPERTENSIVE AND HYPERTENSIVE SUBJECTS

Background: When the blood pressure rises, there is decrease in coronary blood flow to the endocardium and mid-myocardial cells, thereby slowing repolarization in these areas. The major underlying pathophysiology in essential hypertension is arterial stiffness. In this study we compared arterial stiffness index (ASI), T wave peak to end interval (Tpe) and Q to T wave (QT) interval on ECG tracings. Methods: It was a cross-sectional study. Written informed consent was obtained from all subjects. Using non-probability convenience sampling a total of ninety (90) male subjects aged 35â€“55 years were selected and divided into 3 equal groups, i.e., normotensive, prehypertensive and hypertensive. Blood pressure was measured with mercury sphygmomanometer according to the standard protocols. The ASI was calculated from digital volume pulse recorded by photoplethysmography via iWorx-214; physiological interface system. The 12-lead surface EGG was recorded with Delta-1 Plus digital ECG machine. The ECG tracings were scanned and saved in the computer. QTc, cQTp and cTpe/QTc ratio was calculated in normotensive, prehypertensive and hypertensive middle-aged men. These intervals were corrected by Bazzetâ€™s formulae. Results: The ASI was significantly different (p<0.0001) amongst the groups along with QTc and cQTp. However, cTpe intervals and cTpe/QTc were comparable amongst the groups. Conclusion: ASI is major culprit in pathophysiology of hypertension. QTc and cQTp interval are more robust parameter than other ECG markers in detecting trans-mural dispersion of repolarization in prehypertensive and hypertensive subjects. Pak J Physiol 2018;14(2):34â€“7
Keloid Treatment with High Intensity Focused Radiofrequency: A Case Report

Keloids and hypertrophic scars are the product of an imbalance in collagenesis and lysis following damage to the skin. A variety of surgical and nonsurgical approaches have been used to treat keloids, but the results have typically been disappointing. High-intensity focused radiofrequency (HiRF) is a novel treatment method for cutaneous conditions, including scar revision; this method involves fractionated radiofrequency (RF) energy being delivered via insulated microneedles at preset depths in the dermis. The present case study assessed treatment of keloids with HiRF. A 27-year-old Caucasian female developed keloids along the jawline following the appearance of pregnancy-related cystic acne. She was treated with two sessions of HiFR at a four-week interval, with three passes at varying depths for each session. Erythema and edema appeared post-treatment but resolved spontaneously. Ten weeks after the final session, significant improvement was noted with high patient satisfaction. While this is only a single case report, the positive result for this difficult-to-treat keloid scar merits further studies with larger populations of keloid sufferers. This unique method of delivery of fractionated RF energy directly into the dermis, under an intact epidermis, using HiFR via insulated microneedles at three decreasing preset depths for each session, may have corrected the imbalance between collagenesis and lysis through induction of the wound healing process. This ‘bottom up’ method of damage delivery and repair might offer better results in keloid scars than the traditional ‘top down’ approach associated with laser treatment.
Investigaciones recientes en peritonitis infecciosa felina

Feline infectious peritonitis (PIF) is a viral infectious disease caused by the mutation of the feline coronavirus. Is prevalence in cats less than two years old that are kept in overpopulated environments. Currently, since there is no specific test to diagnose this disease, veterinarians rely on the knowledge of the behavior of the condition to give a definitive diagnosis, and thus have a prognosis that allows establishing a palliative treatment. The objective of this article of literature review, where 67 articles on feline infectious peritonitis were collected, is to gather relevant information about this pathology, which allows a greater knowledge about epidemiology, transmission, clinical symptoms, diagnostic tests and treatment current.
Biochemical andGenetic Analysis ofDominant-Negative Mutations Affecting a YeastG-Protein y Subunit

STE18alleles. We obtained dominant-negative mutations thatdisrupt C-terminal sequencesrequired forprenylation ofG,precursors (CAAXbox)andthataffect residues intheN-terminal halfofStel8p. Overexpression ofmutantG. subunits inwild-type cells blocked signal transduction; thiseffect was suppressed uponoverexpression ofG.subunits. MutantG,subunits may therefore sequester Gosubunits intononproductive GO-, dimers. Because mutantG, subunits blocked theconstitutive signal resulting fromdisruption oftheGa,, subunit gene(GPA1), they are defective infunctions required fordownstream signalling. Stel8p bearing a C107Ysubstitution intheCAAX boxdisplayed reduced electrophoretic mobility, consistent witha prenylation defect. G.y subunits carrying N-terminal substitutions hadnormalelectrophoretic mobilities, suggesting thattheseproteins were prenylated. G,subunits bearing substitutions intheir N-terminal region or C-terminal CAAX box(C107Y) supported receptor-G protein coupling invitro, whereasC-terminal truncations causedpartial defects in receptor coupling.