Chemoprotective Evaluation of Ameliorative Effect of Fragaria × Ananassa Duch Fruit Extract against Doxorubicin Induced Toxicities in Wistar Rats .

Cancer is worldwide burden and is addressed from decades, and need to be put an end. Chemotherapy produces genotoxicity. Nature is the best remedy for every toxicity, if it should be properly put to use/ studied. In our study we use extract for reduced the clastogenotoxicity, hepatotoxicity and nephrotoxicity that were induced by doxorubicin single dose (12 mg/kg i.p). Rats were orally pre-treated with Fragaria × ananassa Duch extract (200 and 400 mg/kg) for five consecutive days. On 5th day, these animals were injected with Doxorubicin and sacrificed after 24 hrs for evaluation of oxidative stress, kidney function test, liver function test, micronucleus formation, and chromosomal aberrations. Thus the present study indicates the protective effect of Fragaria × ananassa Duch extract KEYWORD: Clastogenotoxicity, Hepatotoxicity, Nephrotoxicity, Micronucleus, Chromosomal aberration. INTRODUCTION: Cancer is one of the most common fatal diseases in global society. Chemotherapeutics are often used to inhibit the proliferation of cancerous cells. Doxorubicin (DOX), widely used drug is a part of drugs known as anthracycline antibiotics. It is extensively used for the treatment of various types of solid and hematogenous tumors including cancer of blood, bone, breast, ovaries, testicles, thyroid, head and neck, bladder, stomach and soft tissues etc. However, application of DOX as an effective chemotherapeutic agent is often restricted because of its extensive adverse side-effects that include nausea, vomiting, hemopoetic suppression, nephrotoxicity, hepatotoxicity, urotoxicity, cardiotoxicity, immunotoxicity, mutagenicity, carcinogenicity, and teratogenicity. Natural products have been shown to be an outstanding and consistent source for the development of new drugs. Flavonoids and phenolic compounds are found to exhibit diverse biological properties, including hepatoprotective, anti-bacterial, and anticancer activities. The advantages of phenolic compounds are generally thought to be due to their antioxidant and free radical scavenging properties The numerous beneficial effects attributed to phenolic compounds have given rise to a new interest in finding vegetal species with high phenolic content and relevant biological activity. Among them, berries constitute a rich dietary source of phenolic antioxidant and bioactive 6+ Properties. Strawberry (Fragaria × ananassa Duch) berry fruit play a fundamental role in the antioxidant, chemopreventive, and anti-inflammatory activities, but in addition to anthocyanins, other phenolic compounds, such as ellagitannins and flavonols, seem to exert a protective role in carcinogenesis by reducing the bioavailability of carcinogens Many studies have also confirmed the influence of genotype on the phytochemical composition of strawberry fruit antioxidant capacity, so that it is possible to find new genotypes and cultivars producing fruit with higher contents of bioactive compounds, explore new genetic resources, or develop tailored breeding programs. In the present investigation, I have investigated the beneficial effects of Fragaria × ananassa Duch against DOX oxidative stress, genotoxicity, hepatotoxicity and nephrotoxicity.