Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognosis and severity of myelin oligodendrocyte glycoprotein‐immunoglobulin G‐related diseases

Myelin oligodendrocyte glycoprotein‐immunoglobulin G‐related demyelinating disease is part of a relatively new disease spectrum that differs from multiple sclerosis. A recent European study showed that adult onset myelin oligodendrocyte glycoprotein‐immunoglobulin G‐related demyelinating disease might have frequent relapses and a poor prognosis similar to anti‐aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorders.
COMMENTARY: Dementia after Three Months and One Year from Stroke: New Onset or Previous Cognitive Impairment?

In a non-negligible percentage of cases, ranging from 20% to 80%, stroke was associated with the occurrence of a variable degree of cognitive impairment5-8, from mild cognitive deficit to frank dementia. This wide range of prevalence rates could be attributed to differences in care setting, inclusion/exclusion criteria (presence of pre-stroke dementia, primary vs recurrent stroke), criteria adopted for the diagnosis of cognitive impairment, and the interval time after stroke.
Automated control of products by methods of short-wave electromagnetic radiation

The paper considers the problem of effective automation of non-destructive testing of welded joints. The boundaries of the study include short-wave methods of electromagnetic control of products on the example of radiography. The author describes the developed methodology for the automated control of products by the methods of short-wave electromagnetic radiation, which includes: automated control algorithms and software based on them; description of the generated sequence of automated control; software application practices, including end-to-end examples of automated control. An artificial neural network is used as a data processing method.
Gradient of tactile properties in the rat whisker pad

The array of vibrissae on a rat’s face is the first stage in a high-resolution tactile sensing system. Progressing from rostral to caudal in any vibrissae row results in an increase in whisker length and thickness. This in turn may provide a systematic map of separate tactile channels governed by the mechanical properties of the whiskers. To examine whether this map is expressed in a location-dependent transformation of tactile signals into whisker vibrations and neuronal responses, we monitored whiskers’ movements across various surfaces and edges. We found a robust rostral-caudal gradient of tactile information transmission in which rostral shorter vibrissae displayed a higher sensitivity and a bigger differences in response to the different textures, whereas longer caudal vibrissae were less sensitive to the different textures. Nonetheless, we found that texture identity is not represented spatially across the whisker pad. Based on the responses of first-order sensory neurons, we found that neurons innervating rostral whiskers were better suited for textures discrimination, whereas neurons innervating caudal whiskers were more suited for edge detection. To examine the functional role of this organization, we monitored the whisking activity of awake rats foraging for food. We found a caudal-rostral gradient of whisking angle movements in which the longer caudal vibrissae spanned a larger space making them more suitable for object localization, whereas the rostral shorter vibrissae hardly moved. These results suggest that the whisker array in rodents forms a sensory structure in which different facets of tactile information are transmitted through location-dependent gradient of vibrissae on the rat’s face.
Designing pre-bariatric surgery education: The value of Patients' experiences

Within the field of bariatric surgery, preoperative education to empower patients to adapt to the postoperative lifestyle and get the best outcomes in terms of health and quality of life is not standardised across the UK and is based mainly on clinical experience. In this study, the authors used qualitative research and a structured framework to design a preoperative psychosocial education course for people undergoing surgery. Qualitative interviews were performed to determine issues that previous surgery recipients felt were missing from their preoperative education, and the current educational course was redesigned to include this content. The study provides a template from which other Trusts could evaluate and improve their education.
Profile of seekers of an internet-based self-help program for depression in India: observations and implications

Background: Growing awareness of treatment gap for common mental health problems has provided an impetus to development of a variety of mental health apps. However there is a dearth of literature on potential users of such apps in India. Information of this nature can be vital in efforts at further development and dissemination of such apps for enhancing their public health impact. Methods: The paper focuses on examining the profile of individuals who expressed an interest in a newly developed internet based self-help program, called PUSH-D (Practice and Use Self-Help for depression). The PUSH-D pilot-trial was announced on various platforms and participation was solicited from individuals in the community. All those who communicated an interest were requested to participate in an initial evaluation session. Hundred and two individuals completed the evaluation that involved use of interviews and standardized questionnaires to assess depression severity, well-being, and functional impairment. Results: An average PUSH-D seeker was likely to be a young adult, with at least undergraduate level of education and was equally likely to be a male or a female. PUSH-D seekers were likely to have major depression or dysthymia; with mild to moderate severity of symptoms and significant impairment in functioning. Co-morbidities were evident only in a minority of PUSH-D seekers. Conclusions: About two third of PUSH-D seekers had never sought mental health services. Various barriers to seeking face to face professional consultations were reported. The results highlight the potential role of internet- based self-help programs for addressing treatment gap in India.
An IC-level countermeasure against laser fault injection attack by information leakage sensing based on laser-induced opto-electric bulk current density

Laser fault injection (LFI) attacks on cryptographic processor ICs are a critical threat to information systems. This paper proposes an IC-level integrated countermeasure employing an information leakage sensor against an LFI attack. Distributed bulk current sensors monitor abnormal bulk current density caused by laser irradiation for LFI. Time-interleaved sensor operation and sensitivity tuning can obtain partial secret key leakage bit information with small layout area penalty. Based on the leakage information, the secret key can be securely updated to realize high-availability resilient systems. The test chip was designed and fabricated in a 0.18 μm standard CMOS, integrating a 128-bit advanced encryption standard cryptographic processor with the proposed information leakage sensor. This evaluation successfully demonstrated bulk current density and leakage bit monitoring.
Implementation of e-Learning Modules in Viola Instrument Course-Indria Level Practical Learning

— The development of e-learning is a form of quality improvement undertaken to achieve effective learning. The Music Department, as one of the study programs at Universitas Negeri Surabaya, has two types of courses, namely theory and practice. The purpose of this study is to develop e-learning learning to facilitate students to practice independently. Indria Level Strings Instrument Course, suitable to be transformed in e-learning, because this is a course that requires intense learning time. According to its characteristics, this course requires concrete examples of playing, so students understand precisely through video shows. Students are facilitated to recall material, students can access anywhere. Through e-learning learning, student competencies deepen, the quality of learning becomes effective. This research uses the Research and Development method. The product is in the form of a learning module for the Indria Level Viola Instrument course to improve the quality of learning of music students. The product trial was conducted at the Music Department, Universitas Negeri Surabaya, with purposive sampling. Data analysis of the product validity results is arranged in a Likert Scale questionnaire. Every statement describing the aspect of product validity testing is in accordance with the criteria of the Indonesian National Education Standards Agency. The development of this module shows significant results in learning. Shown in the effectiveness of the e-learning module test results at a percentage of up to 90%, students are able to process and implement every material and video contained in the e-learning module. Referring to Bloom's taxonomy, the Indria Level Viola Instrument e-learning course’s able to reach the Psychomotor P5 (Skilled Movement) domain. This achievement shows that the e-learning module facilitates students to practice independently.
Improvement of interfacial interaction in impregnated wood via grafting methyl methacrylate onto wood cell walls

Abstract Improving the interaction between the wood cell wall and a modifying agent is fundamental to enhancing the efficacy of wood modification. The extent of interaction is, nevertheless, difficult to evaluate due to the highly heterogeneous nature of the modified wood. In this study, methacryl groups were grafted onto the wood cell wall polymers, via the reaction between 2-isocyanatoethyl methacrylate (IEMA) and hydroxyl groups, to improve their compatibility and reactivity. Subsequently, methyl methacrylate (MMA) was introduced into methacrylated wood and copolymerized with the bonded methacryl groups. The distribution of IEMA and poly MMA (PMMA) in the wood cell walls was investigated by scanning electron microscopy (SEM) and confocal Raman microscopy. The results showed that MMA penetrated the wood cell walls and formed strong interfacial interaction, which was confirmed by confocal Raman microscopy combined with principal component analysis (PCA). With copolymerization, the highest anti-swelling efficiency (ASE) (57%) was achieved, because of the effect of methacrylation. Compared to the reference, the water resistance and hardness were significantly improved. In addition, the dynamic wettability was also altered largely due to copolymerization.
Inferencia estadística a partir de varios modelos y su utilidad en ecología

© 2018. Los Autores. Editado por la AEET. [Ecosistemas no se hace responsable del uso indebido de material sujeto a derecho de autor] Cuando hacemos modelos ecológicos, normalmente nos interesa conocer la importancia y el efecto de una serie de variables potencialmente explicativas en una variable respuesta de interés. Tradicionalmente, la estrategia escogida por muchos ecólogos ha sido la de contrastar nuestro modelo con una hipótesis nula o la de añadir o quitar variables explicativas, paso a paso, hasta encontrar el “mejor” modelo (Johnson y Omland 2004).
Efficacy and prognostic factor analysis in second-line chemotherapy for elderly patients with metastatic gastric cancer.

143Background: Recently, the proportion of elderly patients (pts) with advanced gastric cancer has increased in Japan. Survival benefits of second-line chemotherapy (CTX) such as weekly paclitaxel (PTX)±Ramucirumab (RAM) or irinotecan (CPT) were shown in several phase 3 trials for metastatic gastric cancer (mGC). However, efficacy and prognostic factors in the second line CTX for elderly pts are not well studied. Methods: We retrospectively reviewed for mGC pts aged ≥ 70 years who underwent PTX+RAM, PTX or CPT as second-line CTX. Eligibility criteria were as follows: PS 0-2, refractory to an S-1containing CTX. Response rate (RR), overall survival (OS), progression-free survival (PFS), and adverse events (AEs) were evaluated. Univariate and multivariate analyses were performed to determine prognostic factors of survival. Results: There were 250 pts with mGC treated at our institution between April 2007 and March 2017. Of all, total of 85 pts were eligible. Median age was 75 years (71-85). The RR was 28.0% .
Medium‐range global ensemble prediction system at 12 km horizontal resolution and its preliminary validation

Forecasts of high‐impact weather systems require sufficiently high resolution of state‐of‐the‐art numerical models in order to resolve the small‐scale features. At the National Centre for Medium Range Weather Forecasting (NCMRWF) in India, a global ensemble prediction system (EPS—called the NEPS) has been implemented operationally at 12 km horizontal grid size. The NEPS configuration is based on the UK Met Office Global and Regional Ensemble Prediction System (MOGREPS). Initial condition perturbations are generated by the ensemble transform Kalman filter (ETKF) method. Model uncertainties are taken care of by stochastic kinetic energy backscatter (SKEB) and random parameters (RP) schemes. Forecast perturbations obtained from 6 hr short forecasts of 22 ensemble members are updated by the ETKF four times a day (0000, 0600, 1200 and 1800 UTC). Perturbations of surface parameters such as sea‐surface temperature, soil moisture content and soil temperature are also included in the new NEPS. The NEPS aims to provide 10 day probabilistic long forecasts using 23 ensemble members (22 perturbed plus one control). The long forecast provided at 0000 UTC is the combination of 11 members from the 0000 UTC cycle and lagged 11 members from the 1200 UTC cycle. The new NEPS shows improvements in terms of forecast agreement among the members in comparison with the previously operational NEPS that was running at 33 km horizontal grid size with 44 perturbed members. The ratio between the root mean square error of the ensemble mean and ensemble spread as a function of lead time has improved in both the Northern and Southern Hemispheres in the new NEPS.
Uso de péptidos neurales modificados como tratamiento de una lesión en la médula espinal: una vision general Use of neural-derived peptides as therapy for spinal cord injury: an overview

Spinal cord injury ( sci ) is a phenomenon that damages the central nervous system ( snc ) causing the loss of physiological activity beneath the injured area. Currently, no effective treatment exists against sci in the clinical field. The role of the immune system through protective autoimmunity ( pa ) -a physiological phenomenon developed after sci -could be of great relevance to induce neuroprotection. pa can be stimulated by using neural-derived peptides ( ndp ), obtained from neural constituents like myelin basic protein. This article attempts to provide an overview of this innovative therapeutic strategy, which offers benefits and an en - couraging future. The most relevant basic principles, mechanisms and preclinical outcomes using the ndp a91 will be revealed. Finally, clinical obstacles to surpass will be stated.
Premutation Allele Combined with Caregiver Distress Factor Increase the Risk of Depression in Fragile X Carriers: Indonesia Setting

: This study was done to determine the risk of anxiety and depression symptoms among fragile X premutation carriers. Hamilton anxiety rating scale (HARS) and Hamilton depression rating scale (HDRS) was administered by trained physicians to measure the severity of anxiety and depression symptoms, respectively. Caregiver distress factors which directly contribute to caregiver burden in particular degree of relationship with the child, number of FXS child, child institutional/educational status, number of hours spent providing care per day, and the degree of illness severity were documented. Thirty-one fragile X carriers (27 females, 4 males), aged 32-77 years participated in this study. Only 3.2% had anxiety symptoms, while depression symptoms were identified in 35.5% carriers. Number of hours of providing care/day were significantly associated with depression symptoms ( p <0.001). The prevalence ratio (PR) of depression among individuals who had a distress score above cut-off was 3.2 (95% CI= 1.2 to 8.5) compared to those who had a distress score below cut-off with p =0.02. Fragile X premutation carriers are at a greater risk to develop depression symptoms related to the hours spent in caring for children with fragile X syndrome (FXS).
Development and control of smart pneumatic mckibben muscles for soft robots

Animals exploit soft structures to move smoothly and effectively in complex natural environments. These capabilities have inspired robotic engineers to incorporate soft actuating technologies into their designs. Developing soft muscle-like actuation technology is one of the grand challenges in the creation of soft-body robots that can move, deform their body, and modulate body stiffness. This paper presents the development of smart pneumatic McKibben muscles woven and reinforced by using conductive insulated wires to equip the muscles with an inherent sensing capability, in which the deformation of the muscles can be effectively measured by calculating the change of wire inductance. Sensing performance of a variety of weaving angles is investigated. The ideal McKibben muscle models are used for analysing muscle performance and sensing accuracy. The experimental results show that the contraction of the muscles is proportional to the measured change of inductance. This relationship is applied to a PID control system to control the contraction of smart muscles in simulation, and good control performance is achieved. The creation of smart muscles with an inherent sensing capability and a good controllability is promising for operation of future soft robots.
Actividad física en adultos con y sin diabetes en México (ENSANUT MC-2016)

Physical activity patterns play a key role in diabetes development and control. Our aim is to describe and compare physical activity/inactivity behaviors in general population with and without diabetes in Mexico and changes associated with sociodemographic and health variables. Information from the Halfway National Health and Nutrition Survey 2016 (ENSANUT MC-2016) is used. The findings show that adults with diabetes, from 60 to 69 years old, with obesity and living in the Northern Mexico, are more likely to be inactive. As well as have a higher physical inactivity prevalence (p = 0,000) and a lower proportion of high physical activity (p = 0,002) in adults with diabetes than in those without diabetes. We conclude that persons with diabetes trend more towards behaviors associated with physical inactivity and that it is necessary to generate more research that contributes to explain this phenomenon.
P140 Factors associated with development of NAFLD in patients with inflammatory bowel disease: a 5-year retrospective study on 225 patients

Patients with IBD are at higher risk for non-alcoholic fatty liver disease (NAFLD) comparing to general population. Complex pathogenesis of NAFLD in IBD may be related to disease-specific risk factors such as chronic inflammation, steroid exposure, drug induced hepatotoxicity, malnutrition and alteration of gut microbiota, which is emerging as a major factor in the pathogenesis of NAFLD. The goal of the study was to investigate factors associated with NADLF and advanced liver fibrosis (ALF) in patients with CD and UC. This is a retrospective study on IBD patients without extraintestinal manifestations and known liver disease. NAFLD was defined as Hepatic Steatosis Index (HSI) ≥ 36, and ALF was defined as FIB-4 ≥ 2.67. Predictors of NAFLD development were analysed using Kaplan–Meier and Cox regression analyses. In this retrospective study, we have included 225 IBD patients; 72.4% (n = 163) patients with CD and 27.6% (n = 62) patients with UC (median age 41.2 yr, 53.7% males) which were observed for a median of 4.6 years. There were 63.1% (n = 142) patients with normal BMI, 27.6% (n = 62) overweight and 9.3% (n = 21) obese patients. Obese patients had the highest HIS score 43.9 ± 5.9, following with overweight 37.8 ± 5.7 and normal BMI 30 ± 4.3 kg/m2, p < 0.001. During the follow-up obese and overweight patients had higher risk of developing NAFLD comparing to patients with normal BMI (obese HR = 11.1 95% CI 4.3–28.3 and overweight HR = 5.55 95% CI 3.4–9.1, Logrank test p < 0.001) (Figure 1). Regarding FIB-4 score there, was no difference among different BMI categories (p = 0.192), and there was no difference in ALF development in the follow-up period (Logrank test p = 0.91). In Cox proportional-hazards regression significant predictors for NAFLD development were dyslipidaemia HR=2.11, 95% CI 1.2–3.7, overweight HR=6 95% CI 3.6–10, and obesity HR=13.4, 95% CI 7–35. NAFLD is frequent comorbidity in patients with CD and UC, which can lead to development of advanced liver fibrosis. Our results show that patients with IBD have a high risk of NAFLD development, whereas the increased risk for ALF was not observed. Overweight and obese patients and those with dyslipidemia should be closer monitored due to significantly higher risk of NAFLD. This study points out the complexity disease-specific risk factors and importance of better stratifying IBD patients at risk of NAFLD and advanced liver fibrosis.
Ionospheric Monitoring and Modeling Applicable to Coastal and Marine Environments

Ionospheric monitoring and modeling in costal and marine environment is reviewed and characterized in terms of state of art, global, regional, and local issues across different domains of solar-terrestrial conditions for practical applications. Their effects on critical technological systems are either controlled by the Earth ’ s ionosphere, as in telecommunications and information systems, or simply influenced by its variability, as in trans-ionospheric radio communication, and navigation systems. The evolution of long-distance high-frequency (HF) communications and then still the actuality of HF radio links especially for the coast environment, maritime services, and aeronautical applications, for control and emergency services, for communications equally important in case of great islands and remote areas, for economic reasoning and easy management, and for efficient backup in case of cyber threats are discussed. Some preferred methods for a proper assessment of HF networks have been identified, and examples of existing long-term prediction and near real-time nowcasting in ionospheric space weather modeling to be used, particularly in the Mediterranean area, are presented along with contemporary references.
Análisis de Sentimiento Basado en el Informe de Percepciones de Negocios del Banco Central de Chile

Using the texts of the Business Perceptions Report published quarterly by the Central Bank of Chile, we construct a numerical index that reflects the emotional feeling or tone contained in the documents. For the construction of the index, we use the Sentiment Analysis (SA) or opinion mining methodology to extract the sentiment orientation of the documents, taking into account the positive or negative contextual polarity of their language. The results show that the IPN index has a high and significant correlation with various indices referring to business confidence and economic expectations in the medium term. The correlation with quantitative indicators of activity such as GDP growth, consumption or investment, is lower but still significant. The main contribution of this work is the formulation of a dictionary in Spanish language for SA and the generation of a numerical index through the application of the Sentiment Analysis methodology.