Miracle-dz/UniFAR-FTUs huggingface dataset:
Automated quantitative and qualitative analysis of neuroblastoma cancer tissue

The goal of this thesis is to develop an innovative Computer Aided Diagnosis (CAD) system for the common deadly infant cancer of Neuroblastoma. Neuroblastoma accounts for more than 15% of childhood cancer deaths, and it has the lowest survival rate among the paediatric cancers in Australia. In quantitative analysis the total number of different regions of interest are counted, and qualitative analysis determines abnormalities within the tumour. Quantitative and qualitative analysis of tumor samples under the microscope is one of the key markers used by pathologists to determine the aggressiveness of the cancer, and consequently its therapy. Because of the variety of the histological region types and histological structures in the tissue, analyzing them under the microscope is a tedious and error-prone task for pathologists. The negative effects of inaccurate quantitative and qualitative analysis have led to an urgent call from pathologists for accurate, consistent and automated approaches. Computer Aided Diagnosis (CAD) is an automated cancer diagnostic and prognostic system which enhances the ability of pathologists in the quantitative and qualitative analysis of tumor tissues. However, there are four main issues with developing a CAD system for pathology labs: First is the fluctuating quality of the histological images. Second is a wide range of different types of histological regions and histological structures with complex morphology each adopting a
Reducing Hospitalizations for Acute Decompensated Heart Failure

for the Diagnosis and Management of Syncope of the European Societyof Cardiology. Eur Heart J 2009;30:2631–71.3. Costantino G, Furlan R. Syncope risk stratiﬁcation in the emergencydepartment. Cardiol Clin 2013;31:27–38.4. Sotariades ES, Evans JC, Larson MG, et al. Incidence and prognosis ofsyncope. N Engl J Med 2002;347:878–85.5. Iglesias JF, Graf D, Forclaz A, Schlaepfer J, Former M, Pruvot E.Stepwise evaluation of unexplained syncope in a large ambulatorypopulation. Pacing Clin Electrophysiol 2009;Suppl 1:S202–6.
Hydrologic Responses to Climate Variability and Human Activities in Lake Ziway Basin, Ethiopia

Hydrological impacts of human activities and climate variability on Ketar and Meki watersheds of Lake Ziway basin, Ethiopia were studied using the soil and water assessment tool. Three land-use change and two climate variability scenarios were considered to analyze the separate and combined impacts on annual water balance, monthly streamflow, and spatial distributions of evapotranspiration and water yield. The evaluation showed that changes in land use resulted in an increase in annual surface runoff and water yield for Ketar watershed and an increase in annual ET for Meki. Similarly, the climate variability resulted in a decrease in annual ET, surface runoff, and water yield for Ketar watershed and a decrease in ET for Meki. Overall, climate variability has greater impacts on the monthly streamflow compared to land-use change impacts. Similarly, greater sensitivity in hydrologic response was observed for Ketar watershed compared to Meki watershed.
An empirical investigation on the economic impact of shared patient information among doctors

ABSTRACT This study investigates how an increase in patient information sharing among doctors impacts healthcare costs. To this end, we explore this impact through two mechanisms – the informative role of patient health conditions and the cross-monitoring role against doctor-driven induced healthcare demands. We utilize a unique policy intervention (a drug utilization review) introduced in 2009 in Korea that enables doctors to share outpatients’ prescription histories. Using difference-in-differences, we found that, when patient information is improved, there is a reduction in pharmaceutical spending. This result is especially true for those patients who have relatively weak information-sharing capabilities. Using data on the amount of antibiotics prescribed for the common cold, we find that a cross-monitoring of prescriptions among doctors reduces the amount of unnecessary prescriptions and thus healthcare spending.
A rare case of dicephalic parapagus conjoined twins

Conjoined twins are rare malformations of monozygotic monoamniotic twins affecting between 1 in 50,000 and 1 in 100,000 births. They are expressed by a fusion zone between fetuses that allow the definition of the type of conjoined twins. Dicephalic parapagus are an extremely rare variety in which the laterally united twins have two heads with a single trunk. The prognosis of this form is very poor. Early prenatal diagnosis is possible and remains determinant for optimal management. Unfortunately, this early diagnosis remains a real challenge in the countries with limited resources.
The Use of Biomarkers for the Early Detection of Vulnerable Atherosclerotic Plaques and Vulnerable Patients. A Review

Abstract Acute coronary syndromes represent the most severe consequences of atherosclerosis, most often triggered by the rupture of a coronary plaque, which, for various reasons, has become unstable. In many cases, these rupture-prone vulnerable plaques are difficult to diagnose, because they do not always cause significant obstruction noticeable by coronary angiography. Therefore, new methods and tools for the identification of vulnerable plaques have been proposed, many of which are currently under study. Various biomarkers have been suggested as predictors of a vulnerable plaque, as well as indicators of an increased inflammatory status associated with higher patient susceptibility for plaque rupture. Integration of such biomarkers into multiple biomarker platforms has been suggested to identify superior diagnostic algorithms for the early detection of the high-risk condition associated with an unstable plaque. The aim of this review is to summarize recent research related to biomarkers used for the early detection of vulnerable plaques and vulnerable patients.
Extracting multilayer networks from Sentinel-2 satellite image time series

Abstract Nowadays, modern Earth Observation systems continuously generate huge amounts of data. A notable example is the Sentinel-2 Earth Observation mission, developed by the European Space Agency as part of the Copernicus Programme, which supplies images from the whole planet at high spatial resolution (up to 10 m) with unprecedented revisit time (every 5 days at the equator). In this data-rich scenario, the remote sensing community is showing a growing interest toward modern supervised machine learning techniques (e.g., deep learning) to perform information extraction, often underestimating the need for reference data that this framework implies. Conversely, few attention is being devoted to the use of network analysis techniques, which can provide a set of powerful tools for unsupervised information discovery, subject to the definition of a suitable strategy to build a network-like representation of image data. The aim of this work is to provide clues on how Satellite Image Time Series can be profitably represented using complex network models, by proposing a methodology to build a multilayer network from such data. This is the first work to explore the possibility to exploit this model in the remote sensing domain. An example of community detection over the provided network in a real-case scenario for the mapping of complex land use systems is also presented, to assess the potential of this approach.
Assessing level of pre and post interventional knowledge and attitude for dengue awareness among selected government school student of Bhopal, India

Dengue is a vector-borne disease that is a major health issue worldwide. It is caused by the dengue virus (DENV, 1-4 serotypes), which is one of the important arboviruses in tropical and subtropical regions. Infection by a serotype provides lifelong immunity against that particular serotype, but further infection with other serotypes leads to deadlier form of dengue. But each serotype alone is able to produce the full spectrum of disease. It is mainly transmitted by Aedes aegypti mosquito and also by Aedes albopictus. In India, first ABSTRACT
Global-Scale Archaeological Prospection using CORONA Satellite Imagery: Automated, Crowd-Sourced, and Expert-led Approaches

ABSTRACT Declassified CORONA satellite imagery, collected from 1960–1972 as part of the world’s first intelligence satellite program, provides nearly global, high-resolution, stereo imagery that predates many of the land-use changes seen in recent decades, and thus has proven to be an immensely valuable resource for archaeological research. While challenges involved in spatially correcting these unusual panoramic film images has long served as a stumbling block to researchers, an online tool called “Sunspot” now offers a straightforward process for efficient and accurate orthorectification of CORONA, helping to unlock the potential of this historical imagery for global-scale archaeological prospection. With these new opportunities come significant new challenges in how best to search through large imagery datasets like that offered by CORONA. In contrast to currently popular trends in archaeological remote sensing that seek to employ either automated, machine learning-based approaches, or alternatively, crowd-sourced approaches to assist in the identification of ancient sites and features, this paper argues for systematic, intensive, and expert-led “brute force” methods. Results from a project that has sought to map all sites and related features across a large study in the northern Fertile Crescent illustrate how an expert-led analysis may be the best means of generating nuanced, contextual understandings of complex archaeological landscapes.
Secure Conflicts Avoidance in Multidomain Environments: A Distributed Approach

In a multidomain application environment, it is of paramount importance for different organizations to collaborate with each other to facilitate secure interoperation. However, various types of conflicts related to access control constraints may arise as a result of integrating access control policies for individual domains, such as role inheritance violations (RIVs) and separation of duty violations (SoDVs). Current methods solve the conflicts in a centralized way by withdrawing or removing all crossdomain relationships resulting in the violations with the knowledge of all domains. However, these methods are inappropriate for large-scale systems due to their high computational complexity. In this article, we propose a distributed approach to avoid secure conflicts in a multidomain environment. We first model the role inheritance hierarchies of multiple domains as an interoperation graph. We then develop RIVs and SoDVs avoidance algorithms based on the interoperation graph and the communications among different domains. Each domain can execute the algorithms autonomously and in real time by evaluating whether its succeeding activated role can result in RIVs and SoDVs. We show that the new algorithms perform well in contrast to the existing algorithms.
DC ripple current reduction on a single-phase PWM voltage source rectifier

A novel topology of a single-phase PWM voltage source rectifier, capable of achieving not only sinusoidal input current but also zero-ripple output current, is presented. The rectifier consists of a conventional single-phase PWM voltage source rectifier, a pair of additional switches and an inductor. Hence, the proposed rectifier requires neither a large DC capacitor nor a passive LC resonant circuit. The input current control is achieved by the conventional PWM current control technique. However, DC ripple current reduction control is difficult because one of the switching legs in the DC ripple current reduction circuit is shared with the PWM rectifier circuit. Two control methods referred to here as the DC inductor method and the AC inductor method, are proposed for DC ripple reduction and the characteristics of these control methods are discussed. These control methods are implemented using a microprocessor, and the effectiveness of the circuit is confirmed experimentally. This rectifier has useful applications in UPSs and DC power supplies, especially for cases in which batteries are connected in parallel to the DC line.
Outcome of liver transplant patients at the University Hospital Centre Zagreb

At the University Hospital Centre Zagreb, 37 patients underwent liver transplantation in the period from 2010 to 2014. Six patients had fatal complications in the early post-transplantation period and deceases in the surgical intensive care unit (ICU). All other patients (31) were transferred to the medical ICU and later to the medical ward. The most common indications for liver transplantation were alcoholic liver disease (9 patients) and hepatitis C (8 patients). Two-thirds of the patients were male (67.7%) with an average age of 51 years. Thirty patients were discharged alive from the hospital. Infections developed in nine patients, mostly pneumonia and peritonitis. Only one patient experienced infection caused by multi-drug resistant bacteria, namely peritonitis due to methicillin-resistant Staphylococcus aureus (MRSA). All infections were successfully treated with antibiotics and none of them caused graft rejection.
Market power and stability of financial institutions: evidence from the Italian banking sector

This paper aims to explore the relationship between bank market power and stability of financial institutions in Italy between 2001 and 2012. The authors first test the existence of a U-shaped relationship between market power and financial stability. Second, they regress the market share indicator on bank risk-taking to underline whether financial stability is affected by increasing or decreasing the market power of banks. Third, they explore whether this relationship is affected by the size, level of capitalization and credit insolvency of banks. ,Relying on highly territorially disaggregated data at labor market areas level, the authors estimate the impact of bank market power and other explanatory variables on a proxy of risk taking behavior such as the banking “stability inefficiency” derived simultaneously from the estimation of a stability stochastic frontier. Bank market power is taken into account through an individual measure based on loans. Financial stability is calculated through the Z-score. The authors use, as risk-taking measure, the stability inefficiency whose estimation approach is the stochastic frontier analysis. ,The empirical evidence shows that the inefficiency of financial stability is found to be U-shaped related with respect to the measure of market power. Bank size is an essential factor in explaining the relationship between bank market power and risk-taking. Cooperative banks have fewer incentives to gain market power to better perform in term of risks. The reform of the cooperative banks that took recently place in Italy is not supported by the data. ,The relationship between bank market power and financial stability has been analyzed using a rich sample of cooperative, commercial and popular banks in Italy over the 2001-2012 period. The authors rely on labor market areas being sub-regional geographical areas where the bulk of the labor force lives and works. The paper investigates the market power-stability link considering both cooperative and non-cooperative banks. Indeed, specific attention has been paid on cooperative banks because of their mission in favor of the local community as only few studies, to the best of the authors’ knowledge, examine cooperative banking.
Ex vivo and in vivo imaging of mouse parietal association cortex activity in episodes of cued fear memory formation and retrieval

The parietal cortex in rodents has an integrative function and participates in sensory and spatial processing, movement planning and decision-making. However, much less is known about its functions in associative memory processing. Here using Fos immunohistochemical mapping of neuronal activity and two-photon imaging in Fos-eGFP mice we show an involvement of anterior part of the parietal cortex (PtA) in the formation and retrieval of recent fear memory in mice. Using ex vivo c-fos imaging we demonstrate the specific activation of the PtA during recent memory retrieval. In vivo two-photon c-fos imaging confirms these results as well as establishes the activation of the PtA neurons during fear memory formation. Additionally, we describe a design of Fos-Cre-GCaMP transgenic mice to investigate long-term changes of calcium dynamics in neurons captured with Fos-TRAP technique during fear conditioning training.
Phase III double-blinded, placebo-controlled study of MABp1 for improving survival in metastatic colorectal cancer.

TPS784 Background: Interleukin 1 alpha (IL-1a) is a pro-inflammatory cytokine that initiates and propagates sterile inflammatory responses. IL-1a is present on the surface of tumors, and released from necrotic cells within the microenvironment, where it upregulates MMPs, VEGF, chemotactic cytokines, and IL-6 contributing to tumor growth and infiltration of the microenvironment by T-regulatory cells and tumor associated macrophages. IL-1a is also found on the surface of platelets and activates vascular endothelium allowing for circulating tumor cells to establish new areas of metastasis. Specific blockade of IL-1a with the true human IgG1k antibody MABp1, is expected to deprive the tumor of its ability to grow, spread, and evade immune surveillance. A phase I/II study showed radiographic evidence of tumor response in mCRC patients, as well as clinically meaningful improvement in cancer associated symptoms, with no significant toxicity. In the context of this therapy, the improvement in key cancer symptoms,.
Cognitive Load Variability from Road Characteristics Should Influence a Safety Requirement for Vehicle Stopping Sight Distance

Current U.S. geometric road design standards are based on a prescribed value for a driver’s perception-reaction time (a constant value of 2.5 seconds), which represents the time necessary for a driver to safely stop the vehicle to avoid a crash (referred to as a stopping sight distance); however, these standards fail to consider how road complexity, driver risk perception, and visual stimuli can influence perception-reaction time. With over a million vehicle fatalities a year (WHO, n.d.), it is necessary to investigate methods of improving driver safety. The influence of road characteristics is considered with some road design policies, but not currently applied to stopping sight distance. This paper introduces theoretical considerations for increasing perception-reaction time (and thereby adjusting speed limits or road geometry) based on roadway complexity (volume of vehicles, road geometry, pedestrian crossings, frequency of adverse weather conditions, or other conditions).
AN ADVANCED IOT BASED ROBOT FOR MILITARY APPLICATION

: The main goal of this paper is to present an “ IOT based Robot which can monitor security conditions in military applications". In this system, a robot is fitted with motors. A micro controller is used to control all operations. According to the motor operations the ROBOT will operate in specified directions. This robot can be controlled by commands received from the user through IOT technology. The robot is having Ultrasonic sensor which will detect the persons. Another sensor is the Proximity sensor which will detect the land mines in the military, if any one of the sensor activate the robot gets stopped and the buzzer will be alert.
A Vision of Health Equity in Housing

This report is the first in a series of reports exploring the role of law in housing equity and innovative uses of law to improve health equity through housing. The reports are based on extensive literature scans and semi-structured interviews with people who are taking action in housing policy and practice. The full series includes: Report I: A Vision of Health Equity in Housing; Report II: Legal Levers for Health Equity in Housing: A Systems Approach; Report III: Health Equity in Housing: Evidence and Evidence Gaps; Report IV: Creative People and Places Building Health Equity in Housing; Report V: Governing Health Equity in Housing; and Report VI: Health Equity through Housing: A Blueprint for Systematic Legal Action. This report describes the strong relationship between housing, neighborhood and health, and reviews old and new evidence about health, health equity and housing to make the case for “health equity in housing” as a top goal of the movement to create a Culture of Health in America. Achieving health equity in housing means that a substantial proportion of people living in the United States will have the option to live in racially and socio-economically mixed communities where all residents benefit from safe and affordable houses, good schools, transportation, parks and recreational facilities, and economic opportunities.
Object detection using radio imaging tomography and tomographic sensors

The article presents the method of detecting objects using radio tomography and tomographic sensors. The solution is based on measuring the radio signal strength between the transmitter and receiver. When measuring the object between the transmitter and the receiver, the value of the signal strength changes as a result of reflection, absorption or dispersion of electromagnetic waves. The application can determine the position using many Wi-Fi signal sources. The main task of the radio tomography presented in the work is to detect the presence of people in specific rooms in real time. As part of the research enabling image reconstruction, a transmission model was used. The measuring system consisted of sixteen antennas. The measured values were the received power expressed in dBm units in a straight line between the individual antennas. Streszczenie. Artykuł przedstawia metodę wykrywanie obiektów za pomocą tomografii radiowej i czujników tomograficznych. Rozwiązanie opiera się na pomiarze siły sygnału radiowego między nadajnikiem a odbiornikiem. W przypadku pomiaru obiektu między nadajnikiem a odbiornikiem wartość siły sygnału zmienia się w wyniku odbicia, absorpcji lub rozproszenia fal elektromagnetycznych. Aplikacja może określić pozycję za pomocą wielu źródeł sygnału Wi-Fi. Głównym zadaniem przedstawionej w pracy tomografii radiowej jest wykrywanie obecności ludzi w określonych pomieszczeniach w czasie rzeczywistym. W ramach badań umożliwiających rekonstrukcję obrazu zastosowano model transmisyjny. System pomiarowy składał się z szesnastu anten. Mierzone wartości były mocą odbieraną wyrażoną w jednostkach dBm w linii prostej między poszczególnymi antenami. (Wykrywanie obiektów za pomocą tomografii radiowej i czujników tomograficznych).
Utilization of Behavioral Health Services by United States Army Medics

ABSTRACT This study assesses potentially traumatic combat and medical provider experiences and subsequent utilization of behavioral health (BH) services among 324 U.S. Army medics 3 months after military deployment. After statistically controlling for socially desirable responding, neither combat nor medical provider experiences directly predicted utilization of BH services; however, both predicted posttraumatic stress symptoms, which predicted BH utilization. Moderation analyses revealed that medics were less likely to utilize BH services after intense battle experiences if they reported a low hardy personality, low unit support, or insufficient sleep. Possible interventions are discussed to promote BH care utilization.