Miracle-dz/UniFAR-FTUs huggingface dataset:
A Rare Case Report: Posterior Dislocation of Shoulder

Abstract Posterior dislocation of the shoulder is a rare. A 18-year-old woman admitted to our department with complaint an injury to her left shoulder. Plain anteroposterior radiography of shoulder showed a posterior dislocation of the left shoulder. Shoulder was reducted. Shoulder was immobilized for 4 weeks Posterior dislocations of the shoulder are uncommon. The keys to making the correct diagnosis involve maintaining a high index of suspicion.
GASTROINTESTINAL TRACT MULTIPLE LYMPHOMATOUS POLYPOSIS PRESENTED AS MANTLE CELL LYMPHOMA

Aims: Mantle cell lymphoma is a mature B cell non-Hodgkin lymphoma which may be presented with the involvement of the gastrointestinal tract as multiple lymphomatous polyposis. The aim of this case report is to increase the awareness of including lymphomatoid polyposis as an entity in the differential diagnosis of multiple polyposis of the gastrointestinal tract. Case Report: A 69-year-old male patient was admitted to the Trakya University Emergency Department with acute abdominal pain. His cli - nical findings were anorexia that started 3-4 months ago together with constipation and nausea causing him to lose 10-15 kg in 7-8 months, with denial of other parameters of B-symptoms (fevers and night sweats). Endoscopic biopsies that were taken from bulbus and duodenum were investigated and he was diagnosed with mantle cell lymphoma. The patient went through an ileoce - cal resection due to his intussusception that caused abdominal pain in the first place. Conclusion: Although being an infrequent disease, gastrointestinal lymphomatoid polyposis should be an entity comprised in differential diagnosis for multiple polyposis of the gastrointestinal tract. On the other hand, there is still not a therapeutic protocol with a definitive cure for gastrointestinal tract mantle cell lymphoma. Elderly patients in high risk group such as our patient should be given treatment by taking their conditions into consideration. Keywords: Mantle cell lymphoma, polyp, non-Hodgkin lymphoma
Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools

Glioblastoma (GBM) is a highly aggressive primary brain tumor. Currently, the suggested line of action is the surgical resection followed by radiotherapy and treatment with the adjuvant temozolomide, a DNA alkylating agent. However, the ability of tumor cells to deeply infiltrate the surrounding tissue makes complete resection quite impossible, and, in consequence, the probability of tumor recurrence is high, and the prognosis is not positive. GBM is highly heterogeneous and adapts to treatment in most individuals. Nevertheless, these mechanisms of adaption are unknown.
Mortality in children and adolescents who present to hospital following non-fatal self-harm: an observational cohort study based on the Multicentre Study of Self-harm in England

Self-harm and suicide in children and adolescents are both growing problems, with self-harm associated with a significant risk of subsequent death, particularly suicide. Long-term follow-up studies are necessary to examine the extent and nature of this association. Method We used data from the Multicentre Study of Self-harm in England to investigate deaths following self-harm to the end of 2015 in 9173 10-18 year-olds who had 13,175 self-harm presentations to the emergency departments of the study hospitals between 2000 and 2013. Deaths were identified through the Office for National Statistics via linkage with data from NHS Digital. Risk factors were examined using survival models.
Astrocytes: Initiators of and Responders to Inflammation

We are in the midst of a glial renaissance; astrocytes, essential for brain homeostasis and neuroprotection, have experienced resurgence in focused analyses. New roles in synaptic plasticity, innate immunity and control of recruited immune cells have placed astrocytes at the center of central nervous system functions. Astrocytes have been shown to receive and convey information to all neural cell types in a coordinated effort to respond to injury and infection, initiating reparative mechanisms. Astrocytes detect injury and infection signals from neurons, microglia, oligodendrocytes and endothelial cells, responding by secreting cytokines, chemokines and growth factors, which may activate immune defenses. While regional heterogeneity in astrocyte form and function has been appreciated since the early 1990s, technologic advances have allowed scientists to show only that astrocytes may be as individualized as neurons. Adult astrocytes may undergo a morphological and functional transformation referred to as astrogliosis. Newly generated astrocytes exhibit heterogenous phenotypes; thus, some remove toxic molecules, restore blood-brain barrier function, and promote extracellular matrix components to support axonal growth and repair, while others inhibit neuronal repair and regeneration. This chapter will introduce some of the cellular and molecular components involved in astrocyte responses induced by inflammatory mediators or pathogens during neuroinflammation or neuroinfectious diseases.
Related factor in lamentation risk of low back pain on inpatient nurse

Low back pain (LBP) is one of the musculoskeletal disorders caused by poor body activity. This study aims to determine the factors associated with the risk of LBP complaints of nurse in the ward at Banten Provincial Hospital. The research method used was analytic observational through cross sectional approach. The research respondents were 34 nurses who were selected by using probability sampling with cluster sampling type. The measurement of age, work period, and BMI used respondent characteristics form, work posture measurement used RULA, and the measurement of LBP complaints used the LBP symptom questionnaire. The statistical test used the chi square test with a significant level (? 0.05). The test results of the relationship between individual characteristics and the risk of LBP complaints obtained age (p=0.677), work period (p=0.811), BMI (p=0.350), and the relationship between work posture and the risk of LBP complaints (p=0.000). Based on the results of research statistics, it was found that there was no significant relationship between age, work period, and BMI with the risk of LBP complaints and there was a relationship between work posture and the risk of LBP complaints. The researcher suggested that the nurse should pay attention to their work posture when conducting nursing intervention. Abstrak Low back pain (LBP) merupakan salah satu gangguan muskuloskeletal yang disebabkan oleh aktivitas tubuh yang kurang baik. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan Risiko keluhan LBP pada perawat Instalasi rawat inap RSUD Provinsi Banten. Metode penelitian yang digunakan adalah analitik observasional melalui pendekatan cross sectional. Responden penelitian sebanyak 34 perawat dengan menggunakan probability sampling dengan jenis cluster sampling. Pengukuran umur, masa kerja, dan IMT menggunakan lembar isi karakteristik responden, postur kerja menggunakan RULA dan pengukuran keluhan LBP dengan kuesioner gejala LBP. Uji statistik menggunkan uji chi square dengan tingkat signifikan (a 0,05). Hasil uji hubungan karakteristik individu dengan keluhan LBP menunjukan hasil umur (p=0,677), masa kerja (p=0,811), IMT (p=0,350), serta hubungan postur kerja dengan keluhan LBP (p=0,000). Berdasarkan hasil data statistik penelitian, tidak ada hubungan yang signifikan antara umur, masa kerja, IMT dengan risiko keluhan LBP dan ada hubungan antara postur kerja dengan keluhan LBP. Peneliti menyarankan agar perawat memperhatikan postur kerja pada saat melakukan intervensi keperawatan.
Managing the consequences of periodontal diseases/treatment: gingival recession

Gingival recession is a widespread clinical finding that can lead to discomfort, root caries and periodontal problems for some patients, yet be of no consequence for others. There are certain factors which may increase the risk of significant recession, and likewise a range of management strategies exist. The causes, identification, risk factors and treatment options for recession are discussed. This will allow the practitioner to recognize the most suitable treatment options in conjunction with the patient, following an informed discussion and, if appropriate, refer for further care. CPD/Clinical Relevance: Whilst gingival recession may be nothing more than a minor inconvenience for some patients, in certain cases it can present a significant problem for patients requiring professional interventions including surgery. This article summarizes the aetiology, diagnosis and management options available.
Limb Girdle Kas Distrofisi 2R (LGMD2R)'de Mekanotransdüksiyonun Rolünün Araştırılması

LGMD2R (MIM 601419) gec baslangicli ve yavas ilerleyen ultra-nadir bir hastalik olup desmin proteininin lamin B baglanma domaininin bozulmasina neden olan bir splice site mutasyonu ile ozdeslesmistir. Hucrelere gelen mekanik iletinin biyokimyasal sinyale donusme islemine mekanotransduksiyon denir. Bozulan mekanotransduksiyon sinyalinin etkileri kas distrofileri de dâhil olmak uzere bircok hastalikta gozlenmektedir. LGMD2R’de ortaya cikan mekanotransduksiyon hasarini gostermek icin kontrol ve hastaya ait hucreler, Flexcell Tension System kullanilarak mekanik yukleme uygulanmistir. Oncelikle MAPK yolagi incelenmistir. ERK1/2 aktivitesinde ve ERK1/2 hedef genlerinde anlamli bir fark gozlenmemistir. Sadece mekanosensitif bir gen olan EGR1 ifadesinde hastada azalis oldugu gorulmustur. Devaminda iskelet kasi mekanotransduksiyonunda kilit rolu olan YAP incelenmistir. YAP stres kosullarinda cekirdekte yerlestiginden, kontrol iskelet kasinda cekirdeklerinin %37,5’i YAP icerirken bunun LGMD2R’de %15,1’e dustugu gosterilmistir. Bununla birlikte statik durumda hastada p-YAP miktarinda 1,5 kat artis gozlenmistir. Hastada mekanik yuklemeden sonra ise hem p-YAP hem de t-YAP miktarinda es zamanli azalis oldugu bulunmustur. Ek olarak YAP tarafindan kontrol edilen genlerin ifade duzeyleri arastirildiginda, hepsi hastada mekanik yukleme ile artarken kontrol ile karsilastirildiginda CTGF ve C-MYC’de azalis oldugu, DIAPH1 ve MYL9’da ise degisim olmadigi gozlenmistir. Ozetle, hastada bazal seviyede YAP aktivitesinin dusmesi ile birlikte, hasta hucrelerinin mekanik yuklemeye yeterli duzeyde cevap veremedigi gosterilmistir. Ilginc olarak ANKRD1 ve ANKRD2’nin S izoformunun ifadelerinde artis bulunmustur. Bu artisin nedeninin LGMD2R’de bozulan mekanotransduksiyon sinyaline karsilik gelisen koruyucu bir mekanizma olabilecegi dusunulmektedir. Bu tez TUBITAK tarafindan desteklenmistir (214S174).
A Study of Mortality in Cardiac Patients in a Pediatric Intensive Care Unit

Objective: One of the major causes of mortality in the pediatric intensive care unit (PICU) is heart disease. This study aimed to determine the causes of mortality in children with pre-existing cardiac abnormalities who were admitted into the PICU. Methods: Data were collected through patient profile assessment and outcome and heart diseases affecting prognosis were analyzed. Medical records of children were reviewed retrospectively. The updated Pediatric Index of Mortality 2 (PIM2) scores were used. Exploratory data analysis was performed using descriptive measures. Kolmogorov-Smirnov tests were used to test the normality of data distribution. Results: Out of 566 admissions into PICU, 76 (13.4%) had cardiac abnormalities. Median and range of PICU stay were 5.50 and 417.88 days. The mean PIM2 score on admission was found to be 31.05. The most common admission was due to atrioventricular septal defect (AVSD) (15.7%), cardiomyopathy (13.1%), ventricular septal defect (VSD) (11.8%), tetralogy of Fallot (10.5%) and others (48.9%). There were multiple cardiac anomalies in 3.9% of patients. The most important cause of cardiac mortality in PICU was septic shock (26.0%) followed by cardiogenic shock (20.6%), and cardiac failure (13.7%). The nosocomial infection rate of cardiac patients in PICU was 10.5%. Conclusions: Our study reconfirmed that the PIM2 score is a good indicator of cardiac diseases. Infections, nosocomial infections, pneumonia, and septic shock were the leading causes of mortality in cardiac patients. Better infection control in the PICU may have a significant impact on decreasing mortality rates.
The Effect of Tenofovir Treatment on Renal Function in Chronic Hepatitis B Patients

Introduction: It is known that chronic hepatitis B virus (HBV) infection is associated with chronic kidney disease. The agents used in the treatment of chronic HBV are safe and well tolerated, but their long-term side effects are largely unknown. We aimed to investigate the effects of antiviral treatments on renal function in patients with chronic HBV follow-up. Materials and Methods: In this study, 156 patients who were followed-up with the diagnosis of chronic HBV in the outpatient clinic of our hospital between 2013-2019 were included. Demographic data of all patients (age, sex), anthropometric characteristics, disease duration, duration of treatment, which antiviral treatment was taken and body mass index were documented. Serum samples were taken from the patients for laboratory analysis before and after treatment. Results: While 92(58.9%) of the patients were male, the mean age of the patients was 48.47±15.1. Mean duration of disease was 91.8±13.6 and mean duration of treatment was 54.9±13.6. There was no significant difference between the antiviral groups in terms of demographic data, anthropometric measurements and liver function tests (p>0.05). In addition, there was no statistically significant difference between the treatment groups in the laboratory measurements performed before and after treatment (p> 0.05). Conclusion: In our study, there was no significant change in renal functions before and after treatment in groups receiving antiviral therapy. However, it is recommended that individuals with chronic HBV who have risk factors such as basal renal dysfunction and comorbidity accompany renal function closely during the Tenofovir treatment.
Bacteriological Profile of Diabetic Foot Infections and its Antibiotic Resistance Pattern in Alexandria Main University Hospital

ISSN: 2319-7706 Volume 8 Number 10 (2019) Journal homepage: http://www.ijcmas. com Diabetic foot is one of the serious complications of DM and may be the initial presentation of undiagnosed diabetes. Foot problems are associated with significant morbidity and impairment in the diabetic patient’s quality of life. This work aimed at studying the bacteriological profile of diabetic foot infections and its antibiotic resistance pattern. This study was carried out on 60 diabetic patients with foot lesions admitted at Diabetic Foot Unit, Alexandria Main University Hospital, during the period from March 2017 to October 2017. An interview questionnaire sheet was filled in, including all the relevant data. Swab samples were collected from each wound after the wound had been cleansed and debrided. A total of 85 microorganisms were isolated, majority of isolates were gram negative (94.1 %), P. aeruginosa isolates were the predominant (34.1%), followed by K.pneumoniae (29.4%), P.mirabilis (12.9%), E.coli (9.4%) then P.vulgaris (8.2%). S.aureus was the only isolated gram positive bacteria (3.51%) and C.albicans was the only isolated fungus (2.4%). Almost all isolated microorganisms were resistant to various antimicrobials. Gram negative organism's infection predominates in DFI. Monomicrobial infection was the most common followed by the polymicrobial infection. Deep wounds were more associated with polymicrobial infection. K e y w o r d s Bacteriological profile of diabetic foot, Diabetic foot
The Benefits of Resistance Training with and Without Weightlifting for Athletic Performance in Adolescent Males

i List of Figures . vi List of Tables . ix Attestation of Authorship . x Co-Authored Works . xi Acknowledgements . xiii Ethics Approval . xv Chapter 1: Introduction . 1 Rationale . 1 Purpose . 2 Significance of thesis . 3 Thesis structure . 4 Chapter 2: Integrating Models of Long-term Athletic Development to Maximize the Physical Development of Youth . 6 Introduction . 6 General long-term athletic development models . 6 Resistance training models for athletic development . 12 Fitness-specific models for athletic development . 16 Strength . 19 Power . 19 Speed . 20 Agility . 21 Aerobic fitness. 22 Conclusion . 23 Chapter 3: Integrating Resistance Training into High School Curriculum . 24 Preface . 24 Introduction . 24 Periodization models . 27 Applying theory to practice: an applied working example from the New Zealand highschool system . 28 Macrocycle. 31
Housing facilities for asylum seekers in Germany: Ethical concerns regarding social exclusion, othering and negative effects on health

Asylum seekers face many barriers in accessing health care and their well-being is impaired in manifold ways. According to Public Health research the impact on health of social determinants is much higher than the influence of access to health care. Therefore, it is important to take other living conditions like accommodation into serious consideration. The focus will be on how housing conditions allow or prevent opportunities for social participation and autonomy. As a philosophical-ethical paper this contribution attempts to identify moral concerns and ethical questions regarding housing situations under the lens of inclusion and exclusion. This will lead to the question whether they constitute forms of othering. In a first step it will be clarified how inclusion and exclusion are used as analytic frame, particularly whether and how far they are not only descriptive terms but also normative ones. Exemplary cases of housing facilities for asylum seekers in Germany will be given and questioned regarding practices of inclusion and exclusion and how this affects participation and autonomy. Apart from contributing to barriers in accessing health care different types of “exclusive” housing for asylum seekers often impedes on social participation and disempowers autonomous choices. Since social exclusion is known to affect (mental) health this raises concerns for health and well-being as well as several other ethical questions. Questions for further discussion: What is the responsibility of Public Health regarding the housing conditions of asylum seekers and the negative effects of othering on health? How do we perceive this in the light of solidarity?
The Effect of Occlusal Pressure on Vertical Force Generation on Dentate and Edentulous Subjects

The Effect of Occlusal Pressure on Vertical Force Generation on Dentate and Edentulous Subjects Matthew Thomas Harper, D.D.S. Objectives: To determine 1) the difference in lower extremity power obtained from a vertical jump in individuals who are dentate or edentulous (implants or dentures) and 2) the difference occlusal pressure makes on lower body force output. Variables included jump height, maximum kicking force, maximum push off force, take off velocity, flight time, jump impulse, and maximum velocity. Groups included dentate, implant overdenture, and conventional denture. Methods: Counter movement jumping with force plate collection was utilized to test the three populations in this study. The three populations were dentate, mandibular implant overdenture opposing maxillary complete denture, and conventional maxillary and mandibular complete dentures. The dentate group was asked to clench their teeth at the beginning and throughout the counter movement jump. The edentulous groups were asked to clench with their prostheses in and to relax with them out. Results: The force variables tested showed significant differences between the three test groups. Maximum velocity was only showed significant between the dentate in comparison to the other two groups, but not between implant or conventional. There was found to be no significant difference between the force variables and occlusal pressure. Conclusions: In the present study, there was a significant difference found between the three dental condition groups of edentulous, implant, and dentate. The results indicate that the oral rehabilitation method did impact lower body force generation in all of the variables, with the exception of maximum velocity which only showed significance between edentulous and dentate.
Frailty and the Burden of Concurrent and Incident Disability in Patients With Cirrhosis: A Prospective Cohort Study

Frailty results from the chronic effects of malnutrition and muscle wasting in patients with cirrhosis. It is well‐established that frailty is strongly associated with mortality in this population. However, little is known of its relationship with physical disability, a critical patient‐centered outcome. Adults with cirrhosis underwent outpatient testing of frailty using the Liver Frailty Index (LFI) and disability using activities of daily living (ADL; range 0‐6) and Instrumental ADL (IADL; range 0‐8) scales at one center between 2012 and 2016. We used adjusted multilevel logistic mixed‐effects regression to test the association between frailty and current disability (impairment with ≥1 ADL or IADL) and incident disability at 6 months among those without baseline disability. Of the 983 participants, 20% were robust, 32% were less robust, 33% were prefrail, and 15% were frail; 587 (60%) had at least 1 assessment. The percentage of participants with at least 1 baseline ADL or IADL impairment was 28% and 37%, respectively. In adjusted regression models, each point LFI increase was associated with a 3.3 and 4.6 higher odds of current difficulty with at least 1 ADL and IADL (P < 0.001 for each), respectively. Among participants without baseline disability, each point LFI increase was associated with a 2.6 and 1.7 higher odds of having difficulty with at least 1 ADL and IADL at 6 months, respectively. Conclusion: Frailty is strongly associated with concurrent and incident disability in patients with cirrhosis. In the clinic, the LFI can be used to identify those in greatest need for additional support/resources to maintain functional independence. In research settings, the LFI may help to identify an enriched population for clinical trials of interventions aimed at those most vulnerable to disability.
Der Schlaganfall als Risikofaktor für osteoporotische Frakturen

Zusammenfassung Im Rahmen der demographischen Entwicklung in Deutschland nimmt die Zahl der Personen, welche einen Schlaganfall erleiden, stetig zu. Überlebende eines Schlaganfalls haben im Vergleich zur altersgleichen Bevölkerung ein erhöhtes Risiko, eine Fragilitätsfraktur zu erleiden. Für Personen über 65 Jahre mit Schlaganfall wurde eine Inzidenz von 33,6 Frakturen pro 1000 Personenjahre berechnet im Vergleich zu 21,4 pro 1000 Personenjahre in der altersgleichen Bevölkerung. Ursachen sind hier die erhöhte Sturzneigung sowie eine Verminderung der Knochendichte auf der paretischen Seite. Das Risiko für eine sturzbedingte Fraktur ist dabei abhängig von der wiedererlangten Selbständigkeit. Personen mit anhaltendem Pflegebedarf weisen daher ein deutlich erhöhtes Frakturrisiko auf. In Ermangelung einer ausreichenden spezifischen Evidenz für diese Risikogruppe sollten die Empfehlungen zur Sturzprävention für ambulant lebende Menschen berücksichtigt werden. Hier ist insbesondere ein Gleichgewichtstraining in Kombination mit einem Krafttraining anzuraten. Die Indikation zu einer Basisdiagnostik nach DVO Leitlinie sollte unter besonderer Berücksichtigung des Sturzrisikos überprüft werden. Bei Personen mit einer residuellen Hemiparese sollte die DXA Messung auf der paretischen Seite erfolgen.