Miracle-dz/UniFAR-FTUs huggingface dataset:
Daytime light enhances the amplitude of circadian output in a diurnal mammal

Mammalian circadian rhythms are orchestrated by a master pacemaker in the hypothalamic suprachiasmatic nuclei (SCN), which receives information about the 24 h light:dark cycle from the retina. The accepted function of this light signal is to reset circadian phase in order to ensure appropriate synchronisation with the celestial day. Here, we ask whether light also impacts another key property of the circadian oscillation, its amplitude. To this end, we measured rhythms in behavioural activity and body temperature, and SCN electrophysiological activity in the diurnal murid rodent Rhabdomys pumilio following stable entrainment to 12:12 light:dark cycles at 4 different daytime intensities (ranging from 12.77 to 14.80 log melanopsin effective photons/cm2/s). Rhabdomys showed strongly diurnal activity and body temperature rhythms in all conditions, but measures of rhythm robustness were positively correlated with daytime irradiance under both entrainment and subsequent free run. Whole-cell and extracellular recordings of electrophysiological activity in ex vivo SCN revealed substantial differences in electrophysiological activity between dim and bright light conditions. At lower daytime irradiance, daytime peaks in SCN spontaneous firing rate and membrane depolarisation were substantially depressed, leading to an overall marked reduction in the amplitude of circadian rhythms in spontaneous activity. Our data reveal a previously unappreciated impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms, and highlight the potential importance of daytime light exposure for circadian health.
EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE

Objective Almost 40% of adults worldwide are classified as overweight or obese. Exercise is a beneficial intervention in obesity, partly due to increases in mitochondrial activity, with a potential role for the concomitant increase in nicotinamide adenine dinucleotide (NAD+). Recent studies have shown that increasing NAD+ levels through pharmacological supplementation with precursors such as nicotinamide mononucleotide (NMN) improved metabolic health in high fat diet (HFD) fed mice. We examined the combined effects of NMN and treadmill exercise on the metabolic dysregulation in HFD-induced obesity. Methods Five-week old female C57BL/6J mice were exposed to control diet or HFD. Mice fed HFD were treated with NMN in drinking water (400mg/kg; HNMN), treadmill exercise (HEx) or combined NMN and exercise (HNEx). Results Unexpectedly, NMN administration impaired several aspects of exercise-induced benefits in HFD mice, including glucose tolerance, glucose stimulated insulin secretion from islets and reduced hepatic triglyceride accumulation. Mechanistically, HNEx mice displayed increased antioxidant and reduced prooxidant gene expression in both islets and muscle, suggesting that altered redox status is associated with the loss of exercise-induced health benefits with NMN co-treatment. Conclusion Our data show that NMN treatment blocks the beneficial metabolic effects of exercise in a mouse model of diet-induced obesity in association with disturbances in redox metabolism. Highlights NMN dampened exercise-induced benefits on glucose handling in diet-induced obesity. NMN administration in exercise enhanced ratio of antioxidants to prooxidants. We suggest NMN administration may not be beneficial when NAD+ levels are replete.
All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes

Background: Using genetic scores for fasting plasma glucose (FPG GS) and type 2 diabetes (T2D GS), we investigated whether the fasting, 1-hour and 2-hour glucose thresholds from the WHO 2013 criteria for gestational diabetes (GDM) have different implications for genetic susceptibility to raised fasting glucose and type 2 diabetes in women from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) and Atlantic Diabetes in Pregnancy (DIP) studies. Methods: Cases were divided into three subgroups: (i) FPG ≥5.1 mmol/L only, n=222; (ii) 1-hour glucose post 75 g oral glucose load ≥10 mmol/L only, n=154 (iii) 2-hour glucose ≥8.5 mmol/L only, n=73; and (iv) both FPG ≥5.1 mmol/L and either of a 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, n=172. We compared the FPG and T2D GS of these groups with controls (n=3,091) in HAPO and DIP separately. Results: In HAPO and DIP, the mean FPG GS in women with a FPG ≥5.1 mmol/L, either on its own or with 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, was higher than controls (all P <0.01). Mean T2D GS in women with a raised FPG alone or with either a raised 1-hour or 2-hour glucose was higher than controls (all P <0.05). GDM defined by 1-hour or 2-hour hyperglycaemia only was also associated with a higher T2D GS than controls (all P <0.05). Conclusions: The different diagnostic categories that are part of the WHO 2013 criteria for GDM identify women with a genetic predisposition to type 2 diabetes as well as a risk for adverse pregnancy outcomes.
From Continuous Observations to Symbolic Concepts: A Discrimination-Based Strategy for Grounded Concept Learning

Autonomous agents perceive the world through streams of continuous sensori-motor data. Yet, in order to reason and communicate about their environment, agents need to be able to distill meaningful concepts from their raw observations. Most current approaches that bridge between the continuous and symbolic domain are using deep learning techniques. While these approaches often achieve high levels of accuracy, they rely on large amounts of training data, and the resulting models lack transparency, generality, and adaptivity. In this paper, we introduce a novel methodology for grounded concept learning. In a tutor-learner scenario, the method allows an agent to construct a conceptual system in which meaningful concepts are formed by discriminative combinations of prototypical values on human-interpretable feature channels. We evaluate our approach on the CLEVR dataset, using features that are either simulated or extracted using computer vision techniques. Through a range of experiments, we show that our method allows for incremental learning, needs few data points, and that the resulting concepts are general enough to be applied to previously unseen objects and can be combined compositionally. These properties make the approach well-suited to be used in robotic agents as the module that maps from continuous sensory input to grounded, symbolic concepts that can then be used for higher-level reasoning tasks.
ISTIC’s Neural Machine Translation System for IWSLT’2020

This paper introduces technical details of machine translation system of Institute of Scientific and Technical Information of China (ISTIC) for the 17th International Conference on Spoken Language Translation (IWSLT 2020). ISTIC participated in both translation tasks of the Open Domain Translation track: Japanese-to-Chinese MT task and Chinese-to-Japanese MT task. The paper mainly elaborates on the model framework, data preprocessing methods and decoding strategies adopted in our system. In addition, the system performance on the development set are given under different settings.
A Brassica napus Reductase Gene Dissected by Associative Transcriptomics Enhances Plant Adaption to Freezing Stress

Cold treatment (vernalization) is required for winter crops such as rapeseed (Brassica napus L.). However, excessive exposure to low temperature (LT) in winter is also a stress for the semi-winter, early-flowering rapeseed varieties widely cultivated in China. Photosynthetic efficiency is one of the key determinants, and thus a good indicator for LT tolerance in plants. So far, the genetic basis underlying photosynthetic efficiency is poorly understood in rapeseed. Here the current study used Associative Transcriptomics to identify genetic loci controlling photosynthetic gas exchange parameters in a diversity panel comprising 123 accessions. A total of 201 significant Single Nucleotide Polymorphisms (SNPs) and 147 Gene Expression Markers (GEMs) were detected, leading to the identification of 22 candidate genes. Of these, Cab026133.1, an ortholog of the Arabidopsis gene AT2G29300.2 encoding a tropinone reductase (BnTR1), was further confirmed to be closely linked to transpiration rate. Ectopic expressing BnTR1 in Arabidopsis plants significantly increased the transpiration rate and enhanced LT tolerance under freezing conditions. Also, a much higher level of alkaloids content was observed in the transgenic Arabidopsis plants, which could help protect against LT stress. Together, the current study showed that AT is an effective approach for dissecting LT tolerance trait in rapeseed and that BnTR1 is a good target gene for the genetic improvement of LT tolerance in plant.
Distinct Target-Specific Mechanisms Homeostatically Stabilize Transmission at Pre- and Post-synaptic Compartments

Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the other. However, the expression mechanisms that achieve this exquisite target-specific homeostatic control remain enigmatic. Here, we identify the distinct target-specific homeostatic expression mechanisms. On the hypo-innervated target, an increase in postsynaptic glutamate receptor (GluR) abundance is sufficient to compensate for reduced innervation, without any apparent presynaptic adaptations. In contrast, a target-specific reduction in presynaptic neurotransmitter release probability is reflected by a decrease in active zone components restricted to terminals of hyper-innervated targets. Finally, loss of postsynaptic GluRs on one target induces a compartmentalized, homeostatic enhancement of presynaptic neurotransmitter release called presynaptic homeostatic potentiation (PHP) that can be precisely balanced with the adaptations required for both hypo- and hyper-innervation to maintain stable synaptic strength. Thus, distinct anterograde and retrograde signaling systems operate at pre- and post-synaptic compartments to enable target-specific, homeostatic control of neurotransmission.
In vitro hemo- and cytocompatibility of bacterial nanocelluose small diameter vascular grafts: Impact of fabrication and surface characteristics.

Objective There is an increasing need for small diameter vascular grafts with superior host hemo- and cytocompatibilities, such as low activation of platelets and leukocytes. Therefore, we aimed to investigate whether the preparation of bacterial nanocellulose grafts with different inner surfaces has an impact on in vitro host cytocompatibility. Methods We have synthesized five different grafts in a bioreactor, namely open interface surface (OIS), inverted (INV), partially air dried (PAD), surface formed in air contact (SAC) and standard (STD) that were characterized by a different surface roughness. The grafts (length 55 mm, inner diameter 5 mm) were attached to heparinized polyvinyl chloride tubes, loaded with human blood and rotated at 37°C for 4 hours. Then, blood was analyzed for frequencies of cellular fractions, oxidative products, soluble complement and thrombin factors. The results were compared to clinically approved grafts made of polyethylene terephthalate and expanded polytetrafluoroethylene. Additionally, blood platelets were labelled with 111Indium-oxine to visualize the distribution of adherent platelets in the loop by scintigraphy. Results SAC nanocellulose grafts with the lowest surface roughness exhibited superior performance with <10% leukocyte and <50% thrombocyte loss in contrast to other grafts that exhibited >65% leukocyte and >90% thrombocyte loss. Of note, SAC nanocellulose grafts showed lowest radioactivity with scintigraphy analyses, indicating reduced platelet adhesion. Although the levels of reactive oxygen species and cell free DNA did not differ significantly, the levels of thrombin-antithrombin complexes were lowest in SAC grafts. However, all nanocellulose grafts exhibited enhanced complement activation. Conclusion The systematic variation of the inner surfaces of BNC vascular grafts significantly improves biocompatibility. Especially, SAC grafts exhibited the lowest loss of platelets as well as leukocytes and additionally significantly diminished activation of the coagulation system. Further animal studies are needed to study in vivo biocompatibilities.
In Vitro Fermentation Patterns and Methane Output of Perennial Ryegrass Differing in Water-Soluble Carbohydrate and Nitrogen Concentrations

Simple Summary Globally, the livestock sector is responsible for 37% of total anthropogenic methane emissions, most of which are produced from enteric fermentation of ruminants. Livestock is also responsible for 65% anthropogenic nitrous oxide and 64% of anthropogenic ammonia emissions. The literature reports several dietary management options to reduce greenhouse gas emissions from ruminants, and potentially improve productivity. However, strategies that aim to reduce the emissions of one specific greenhouse gas can have side effects (increase) on other pollutant gases. In this study, we evaluated the effect of two types of perennial ryegrass (PRG) pastures differing in their concentration of water-soluble carbohydrates (WSC, high (HS) and low (LS)) on the in vitro nitrogen use efficiency in the rumen and on methane emissions. The greater WSC and lower crude protein (CP) concentrations of high sugar pastures modified in vitro rumen fermentation, tending to increase total volatile fatty acids (VFA) production, reduce acetate:propionate ratio and methane (CH4) concentration, and improve nitrogen (N) use efficiency through lower rumen ammonia-N (NH3-N) concentrations. In vivo studies with cattle are required to confirm the potential of these measures to increase the sustainability and reduce the environmental impact of grazing livestock production systems. Abstract The objective of this study was to determine the effect of perennial ryegrass (PRG) forages differing in their concentration of water-soluble carbohydrates (WSC) and crude protein (CP), and collected in spring and autumn, on in vitro rumen fermentation variables, nitrogen (N) metabolism indicators and methane (CH4) output, using a batch culture system. Two contrasting PRG pastures, sampled both in autumn and spring, were used: high (HS) and low (LS) sugar pastures with WSC concentrations of 322 and 343 g/kg for HS (autumn and spring), and 224 and 293 g/kg for LS in autumn and spring, respectively. Duplicates were incubated for 24 h with rumen inocula in three different days (blocks). Headspace gas pressure was measured at 2, 3, 4, 5, 6, 8, 10, 12, 18, and 24 h, and CH4 concentration was determined. The supernatants were analysed for individual volatile fatty acids (VFA) concentrations, and NH3-N. The solid residue was analysed for total N and neutral detergent insoluble N. Another set of duplicates was incubated for 4 h for VFA and NH3-N determination. The HS produced more gas (218 vs. 204 mL/g OM), tended to increase total VFA production (52.0 mM vs. 49.5 mM at 24 h), reduced the acetate:propionate ratio (2.52 vs. 3.20 at 4 h and 2.85 vs. 3.19 at 24 h) and CH4 production relative to total gas production (15.6 vs. 16.8 mL/100 mL) and, improved N use efficiency (22.1 vs. 20.9). The contrasting chemical composition modified in vitro rumen fermentation tending to increase total VFA production, reduce the acetate:propionate ratio and CH4 concentration, and improve N use efficiency through lower rumen NH3-N.
Tracking the contribution of inductive bias to individualized internal models

Internal models capture the regularities of the environment and are central to understanding how humans adapt to environmental statistics. In general, the correct internal model is unknown to observers, instead approximate and transient ones are recruited. However, experimenters assume an ideal observer model, which captures stimulus structure but ignores the diverging hypotheses that humans form during learning. We combine non-parametric Bayesian methods and probabilistic programming to infer rich and dynamic individualised internal models from response times in an implicit visuomotor sequence learning task. We identify two contributors to the internal model: the ideal observer model and a Markov model capturing only immediate temporal dependencies between observations. Individual learning curves revealed internal models initially dominated by the Markov model, which was later traded-off with the ideal observer model. Thus, our results reveal a structured inductive bias that varies across individuals both in strength and persistence but is consistent in overall structure.
lron transport in marine phytoplankton: Kinetics of cellular and medium coordination reactions

4bstract Iron is taken up via specific sites on the cell surface in two coastal phytoplankters-the coccolithophorid Pleurochrysis carterae and the diatom Thalassiosira weissflogii. Direct uptake from the cell surface of - 1 O-l7 mol Fe cell-l was observed in pulse-chase experiments with cells grown under IFe limitation. This quantity corresponds to the theoretical number of transport sites needed by each cell given the slow coordination kinetics and the low seawater concentrations of Fe. The observed turnover time of Fe in the sites---20 min-the observed half-saturation constants for uptake-O.7 and 3.1 nM for P. carterae and T. weissflogii-and maximal Fe complexation rates are consistent with a standard model for carrier-mediated transport. Analysis of the reaction kinetics mdicates that the sites are not at equilibrium with dissolved Fe species. Iron uptake rates are thus controlled by the complex formation kinetics of the transport site with monomeric ferric hydroxide species. Fe-limited P. carterae and T. weissjlogii can take up Fe at rates up to 14-20% of the maximum rate at which dissolved inorganic Fe can diffuse to the cell. Since oceanic phytoplankters must also be subject to the same strongly size-dependent limit on uptake rates imposed by diffision, large species are more likely to experience growth rate limitation under low-Fe conditions in the ocean.
Label Noise in Context

Label noise—incorrectly or ambiguously labeled training examples—can negatively impact model performance. Although noise detection techniques have been around for decades, practitioners rarely apply them, as manual noise remediation is a tedious process. Examples incorrectly flagged as noise waste reviewers’ time, and correcting label noise without guidance can be difficult. We propose LNIC, a noise-detection method that uses an example’s neighborhood within the training set to (a) reduce false positives and (b) provide an explanation as to why the ex- ample was flagged as noise. We demonstrate on several short-text classification datasets that LNIC outperforms the state of the art on measures of precision and F0.5-score. We also show how LNIC’s training set context helps a reviewer to understand and correct label noise in a dataset. The LNIC tool lowers the barriers to label noise remediation, increasing its utility for NLP practitioners.
Effect of plant age on resistance to Ascochyta rabiei in chickpea

The impact of plant age on resistance to ascochyta blight of chickpea (Cicer arietinum) was assessed on kabuli cvs. UC27 (susceptible) and Sanford and B90 (partially resistant) and desi cv. Myles (partially resistant) using two isolates of Ascochyta rabiei. Tests were conducted under controlled conditions and in field trials in 1999 and 2000. Seed was sown at regular intervals to produce plants at different growth stages (seedling, vegetative, flowering, podding), which were all inoculated at the same time in randomized complete block experiments with four replications. Cultivar UC27 was highly susceptible at all stages of plant development. However, plant age had a large impact on the reaction of resistant cultivars to A. rabiei. In growth chamber studies, blight severity was low in seedlings of the resistant cultivars (range, 4-20%) and highest in podding plants (41-82%) 2 weeks after inoculation. In the field trials, severity at 2 weeks after inoculation showed a similar pattern, with mean severity among resistant cultivars ranging from 1 to 2% in seedlings and 3 to 28% in podding plants. Severity at 8 weeks after inoculation on plants of resistant cultivars inoculated as seedlings was low (6-14% in 1999, 10-23% in 2000) relative to those inoculated at podding (65-91% in 1999; 54-83% in 2000) in the field trials. These results indicate that resistance decreases with plant age in the partially resistant chickpea cultivars adapted to western Canada and that resistance alone may not provide adequate disease control.
Pragmatic Solutions for Stroke Recovery and Improved Quality of Life in Low- and Middle-Income Countries—A Systematic Review

Background: Given the limited healthcare resources in low and middle income countries (LMICs), effective rehabilitation strategies that can be realistically adopted in such settings are required. Objective: A systematic review of literature was conducted to identify pragmatic solutions and outcomes capable of enhancing stroke recovery and quality of life of stroke survivors for low- and middle- income countries. Methods: PubMed, HINARI, and Directory of Open Access Journals databases were searched for published Randomized Controlled Trials (RCTs) till November 2018. Only completed trials published in English with non-pharmacological interventions on adult stroke survivors were included in the review while published protocols, pilot studies and feasibility analysis of trials were excluded. Obtained data were synthesized thematically and descriptively analyzed. Results: One thousand nine hundred and ninety six studies were identified while 347 (65.22% high quality) RCTs were found to be eligible for the review. The most commonly assessed variables (and outcome measure utility) were activities of daily living [75.79% of the studies, with Barthel Index (37.02%)], motor function [66.57%; with Fugl Meyer scale (71.88%)], and gait [31.12%; with 6 min walk test (38.67%)]. Majority of the innovatively high technology interventions such as robot therapy (95.24%), virtual reality (94.44%), transcranial direct current stimulation (78.95%), transcranial magnetic stimulation (88.0%) and functional electrical stimulation (85.00%) were conducted in high income countries. Several traditional and low-cost interventions such as constraint-induced movement therapy (CIMT), resistant and aerobic exercises (R&AE), task oriented therapy (TOT), body weight supported treadmill training (BWSTT) were reported to significantly contribute to the recovery of motor function, activity, participation, and improvement of quality of life after stroke. Conclusion: Several pragmatic, in terms of affordability, accessibility and utility, stroke rehabilitation solutions, and outcome measures that can be used in resource-limited settings were found to be effective in facilitating and enhancing post-stroke recovery and quality of life.
Diversidad de Braconidae1 Asociada al Limón Mexicano (Citrus aurantifolia Swingle) en Colima, México

Resumen. Se estudió la diversidad de Braconidae en limón mexicano [Citrus aurantifolia Christm. (Swingle)] en Tecomán, Colima, México, identificando 13 subfamilias, 24 géneros, y 54 morfoespecies. La subfamilia con mayor número de géneros y especies fue Doryctinae y los géneros con más especies fueron Heterospilus Haliday, Opius Wesmael, y Bracon Fabricius. Se recolectó 76% de la riqueza real local de acuerdo al estimador ACE, por lo que el esfuerzo de colecta puede considerase representativo, pero también indica que aún es necesario más trabajo de campo para recolectar las especies esperadas en el área de estudio.