Miracle-dz/UniFAR-FTUs huggingface dataset:
Patterns of urban cloud modifications

Clouds in the urban boundary layer interact with the urban land surface via different linkages, resulting in prominent spatial and temporal patterns over or downwind of cities called here patterns of urban cloud modifications. Depending on meteorological context, an enhancement of fair-weather cumulus clouds or a faster dissipation of fog and low stratus can be encountered. As the role of clouds in the climate system is among the largest remaining uncertainties in climate science, a more complete understanding of cloud systems is required and the dynamic urban setting may serve as a testbed.
HUBUNGAN PERCEIVED ORGANIZATIONAL STRUCTURE TERHADAP EMPLOYEE ENGAGEMENT YANG DIMODERASI OLEH PERCEIVED ORGANIZATIONAL SUPPORT

This study aims to examine the relationship between perceived organizational structure and employee engagement which is moderated by perceived organizational support. Organizational support provides assistance for employees in adapting to existing organizational structures. A good organizational structure will improve employee performance and create employee attachments to the work environment. Data from this study were taken from 90 employees of PT. PLN (Persero) Surabaya Office with proportional sampling method. The data analysis technique in this study used multiple linear regression. The results of this study indicate that perceived organizational structure has a positive and significant effect on employee engagement, and perceived organizational support reinforces the positive influence of perceived organizational structure on employee engagement.
Molecular dynamics simulations of water structure and diffusion in silica nanopores

We present molecular dynamics (MD) simulations of water-filled silica nanopores such as those that occur in ordered oxide ceramics (MCM-41, SBA-15), controlled pore glasses (such as Vycor glass), mesoporous silica, bioglasses, and hydrous silica gel coatings of weathered minerals and glasses. Our simulations overlap the range of pore diameters (1–4 nm) where confinement causes the disappearance of bulk-liquid-like water. In ≥2 nm diameter pores, the silica surface carries three statistical monolayers of density-layered water, interfacial water structure is independent of confinement or surface curvature, and bulk-liquid-like water exists at the center of the pore (this last finding contradicts assumptions used in most previous neutron diffraction studies and in several MD simulation studies of silica nanopores). In 1 nm diameter pores, bulk-liquid-like water does not exist and the structural properties of interfacial water are influenced by confinement. Predicted water diffusion coefficients in 1–4 nm dia.
A prospective antibiotic point prevalence survey in two primary referral hospitals during and after pilgrims stay in Madinah, Saudi Arabia

Purpose: To assess current patterns of antibiotic use by carrying out two point-prevalence surveys (PPS) in Madinah after the return of hajj pilgrims from Makkah and when Madinah is free from pilgrims. Methods: In September 2016 and November 2016, a prospective PPS was conducted on two separate dates (during the hajj pilgrims stay in Madinah and after they leave). Data on antibiotics use were generated during these two periods. This involved an audit from all the departments of two referral hospitals (King Fahad Hospital (KFH) - 425 beds, and Al Ansar Hospital - 100 beds) of inpatients records. Data were collected using standard forms adapted from the European Centre for Disease Control (ECDC). Results: A total of 675 inpatients were included in PPS; among them, 332 (49.18 %) patients were receiving antibiotic therapy. In September 2016, 168 patients were treated with antibiotics, with a prevalence rate of 50.60 %, whereas, in November 2016, the prevalence rate was 49.40 %. Overall, 198 patients were identified in surgical wards, of which 132 patients (66.6 %) were receiving antibiotic therapy; 121 patients in ICU of which 70 patients (57.8 %) received antibiotics; 13 patients in other wards of which 6 (46.1 %) received antibiotic treatment; and 343 patients in medical wards of which 126 patients (36.7 %) were treated with antibiotics. There was no significant difference in prevalence of antibiotic prescribing between the two surveys (Pearson Chi-square test, p = 0.56) and with regards to patient age between the two surveys (Mann-Whitney U-test, p = 0.32). Conclusion: The results demonstrate that antibiotic use with adherence to hospital guidelines and PPS helps in identifying targets for quality improvement. Moreover, to escalate the prudent use of antibiotics in hospitals, PPS provides a useful tool. Furthermore, this survey provides a background to evaluate antibiotic use by a standardized methodology. Keywords: Point prevalence survey, Antibiotic use, Prescribing practices, Antibiotic resistance, Quality improvement, Antibiotic stewardship, Hajj, Pilgrims
Phylogeographic study of Musella lasiocarpa (Musaceae): providing insight into the historical river capture events

In the late Pliocene, the Qinghai-Tibet plateau experienced several rapid uplifts. The resulting Hengduan Mountains have since played an important role in the plant distribution pattern in China. Here, a phylogeographic study on wild populations of Musella lasiocarpa (Musaceae), which is endemic to southwest China, is reported. We have discovered 9 wild populations of M. lasiocarpa throughout its natural distribution in cliff habitats in southwest China since 2004. In order to reveal the factors causing the current distribution pattern of wild M. lasiocarpa populations and its spread pathways, phylogenetic analysis by sequencing 3 chloroplast DNA fragments (psbA-trnH, trnL-F and rpl16) were performed. Based on the results, we deduced that the origin of wild M. lasiocarpa populations was in the region of the Lijiang aera of the Jinsha River, which was close to Yanbian, Panzhihua. The differentiation was probably caused by the uplift of the Qinghai-Tibet Plateau, the Hengduan Mountain orogeny, and the westward retreat of the ancient Mediterranean Sea. The main factors that contributed to the fragmentation of wild M. lasiocarpa population habitat include diversion of the ancient Red River and stream capture of its tributaries.
Online Deal Portal: Factors to Consider for an Effective Design

In this research paper we discuss about the relationship between online deals portals and consumers and how it affects an efficient deals portal design. Consumers from all over the globe now order products online, in order to help people, save time and money. The deal portals make this possible by finding best online deals easily. The main purpose this work is to propose factors of design that an online portal should have and will attract consumers using it to find the best deal quickly. A portal that collect deals and discount offers on daily basis from all over the world should satisfy many important factors, such as customer previous online experience, transaction secureness, site usefulness and also product attributes. An online survey was done and it was found that portal ease of use, usefulness and product & company attributes are main influencing factors for making an online purchase decision by a consumer. Also, an analysis of web portals of deal offering sites is given with details of factors that e-commerce site designers should consider while developing a worldwide deals portal site.
High-Density Lipoprotein Antioxidant Responses to High-Intensity Interval and Steady-State Moderate-Intensity Exercise

High-intensity interval exercise (HIIE) may impart health benefits beyond what is acquired through moderate-intensity steady state exercise (SSE). Paraoxonase 1 (PON1), an antioxidant associated with highdensity lipoprotein (HDL), may be altered with exercise; however, it is unclear whether HIIE provides a greater stimulus for increasing PON1 antioxidant activity than a comparable or greater amount of SSE. PURPOSE: Determine the influence of HIIE on PON1 concentration and activity relative to a comparable amount of moderate-intensity SSE and a dose that is half that of SSE. METHODS: Seventeen male participants (age 27.8 + 6.4 yr; weight 80.6 + 9.0 kg; BMI 25.1 + 2.4 kg/m2; %fat = 19 + 5; VO2max 52.1 + 7.5 ml/kg/min) underwent HIIE by treadmill running (90% and 40% of VO2reserve in 3:2 min ratio) to expend 500 kcals (H500); HIIE to expend 250 kcals (H250), and; SSE at 70% VO2reserve to expend 500 kcals (M500) in a randomized crossover design. Intensities of all exercise conditions averaged 70% VO2reserve. Blood measures of total antioxidant capacity (TAC) in copper reducing equivalents, HDL ( g/mL), apolipoprotein A-1 (ApoA1: g/L), PON1 concentration (PON1c: g/mL) and arylesterase activity (PON1a: kU/L) were obtained just before, immediately after, 2 hr and 24 hr after exercise. Significant differences were determined using 3 by 4 repeated measures ANOVAs. Effect sizes were calculated to determine the magnitude of dependent variable responses to exercise. RESULTS: Pre-exercise HDL concentration was lower in H250 and increased most in H250 versus other exercise conditions (p < 0.001, ES = 0.83). Other antioxidant responses were similar across exercise conditions. ApoA1 (+ 8.0%) and PON1a (+ 9.3%) increased immediately after exercise and remained elevated 24 hr after exercise (p < 0.0001 for each; ApoA1 ES = 0.85, PON1a ES = 0.57). PON1c was increased 2.4% above baseline at 2 hr post-exercise (p = 0.0296, ES = 0.18) and TAC was elevated 8.6% above baseline at 24 hr post-exercise (p = 0.0227, ES = 0.48). SUMMARY: HDL and HDL antioxidant properties are transiently potentiated by HIIE with as little as 250 kcals of energy expenditure. HDL antioxidant activity and total antioxidant capacity are elevated with HIIE and SSE of moderate intensity in a similar manner and are observed for up to 24 hr after exercise.
DEEPScreen: high performance drug–target interaction prediction with convolutional neural networks using 2-D structural compound representations

The identification of physical interactions between drug candidate chemical substances and target biomolecules is an important step in the process of drug discovery, where the standard procedure is the systematic screening of chemical compounds against pre-selected target proteins. However, experimental screening procedures are expensive and time consuming, therefore, it is not possible to carry out comprehensive tests. Within the last decade, computational approaches have been developed with the objective of aiding experimental studies by predicting novel drug-target interactions (DTI), via the construction and application of statistical models. In this study, we propose a large-scale DTI interaction prediction system, DEEPScreen, for early stage drug discovery, using convolutional deep neural networks. One of the main advantages of DEEPScreen is employing readily available simple 2-D images of compounds at the input level instead of engineered complex feature vectors that displayed limited performance in DTI prediction tasks previously. DEEPScreen learns complex features inherently from the 2-D molecular representations, thus producing highly accurate predictions. DEEPScreen system was trained for 704 target proteins (using ChEMBL curated bioactivity data) and finalized with rigorous hyper-parameter optimization tests. We compared the performance of DEEPScreen against shallow classifiers such as the random forest, logistic regression and support vector machines, to indicate the effectiveness of the proposed deep learning approach. Additionally, we compared DEEPScreen with other deep learning based state-of-the-art DTI predictors on widely used benchmark datasets and showed that DEEPScreen produces better or comparable results to the top performers. The method proposed here can be employed to computationally scan a large portion of the recorded drug candidate compound and protein spaces to aid the experimentalists working in the field of drug discovery and repurposing by providing a preselection of interesting novel DTIs.
Simulación meteorológica en zona de alta montaña para estimar el potencial eólico

Este trabajo analiza la habilidad del modelo Weather Research & Forecasting (WRF) para representar el campo del viento en zonas de alta montana de Colombia. Para este fin se utilizo, como condiciones iniciales y de frontera, la informacion del modelo Global Forecast System (GFS) con una resolucion espacial de grilla 0.5 x 0.5 grados para el periodo comprendido entre diciembre de 2012 y diciembre de 2013. Ademas, el modelo WRF se ejecuto para las resoluciones de grilla de 3 km x 3 km y 9 km x 9 km combinando siete parametrizaciones de la capa limite planetaria y tres de superficie para un total de 11 simulaciones. El dominio que mejor simula el campo del viento es el de 9 km x 9 km, utilizando las parametrizaciones del esquema de BouLac para la PBL y MM5 para superficie. El esquema de BouLac tiene la ventaja de pronosticar eventos con turbulencia inducida por la orografia, y la parametrizacion de MM5 es mas eficiente para simular flujos turbulentos durante el dia, horas en las cuales los valores de la energia cinetica turbulenta son mas altos. Finalmente, la estimacion del recurso eolico por medio del calculo de los parametros de forma y escala de la distribucion de Weibull muestra que en zona de alta montana, especialmente en los departamentos de Narino, Cauca, Valle del Cauca, Tolima y Quindio, existen regiones en donde la velocidad promedio del viento es superior a 5 m/s, valor que se ajusta para producir energia electrica.
Single user TCP downstream throughput probability models in IEEE802.11b WLAN system

Single User, Transmission Control Protocol Downstream Throughput (TCPDST) probability models in an IEEE802.11b WLAN have been developed, validated and evaluated for performance. Measurement of single user TCPDST were taken using Tamosoft throughput test while that of signal to noise ratio (SNR) were taken using inSSIDer 2.1. The Tamosoft throughput tests were conducted using different quality of service (QoS) traffic. These QoS traffic (which were sent through an infrastructure based network) correspond to different wireless multimedia tags. Measurements were taken in free space, small offices and open corridor environments. By assuming a normal distribution, single user TCPDST Cumulative distribution function (CDF) probability models were developed for different signal categories namely: (i) all the SNR considered, (ii) strong signals only, (iii) grey signals only and (iv) weak signals only. The models were validated and their performances evaluated using root mean square (RMS) errors. RMS errors were computed by comparing model predicted values with validation data. The RMS errors for single user CDF all signals model was 0.1466%. RMS errors for strong signals models, grey signals model and weak signals model respectively were 0.1466%, 0.6756% and 0.1233% indicating acceptable performances. All signals, strong signals, grey signals and weak signals CDF probability models predicted probabilities of obtaining TCPDST values greater than 5Mbps as 74.79%, 90.55%, 13.00% and 4.77% respectively while probabilities of obtaining TCPDST values less than 2Mbps were predicted as 4.91%, 0.00%, 18.98% and 52.41% respectively. These probability models will provide additional useful information needed to design efficient distributed data networks. Keywords: Throughput, TCP, WLAN, probability models
Regulation of stability and copy number of tandem repeats in Saccharomyces cerevisiae

Tandem repeats are inherently unstable and exhibit extensive copy number polymorphisms. Despite mounting evidence for their adaptive potential, the mechanisms associated with regulation of the stability and copy number of tandem repeats remain largely unclear. To study copy number variation at tandem repeats, I used two well-studied repetitive arrays in the budding yeast genome, the ribosomal DNA (rDNA) locus, and the copper-inducible CUP1 gene array. I developed powerful, highly sensitive assays to measure repeat instability and copy number and used them in multiple high-throughput genetic screens to define pathways involved in regulating rDNA copy number variation. These screens revealed that rDNA stability and copy number are regulated by DNA replication, transcription, and histone acetylation. Through parallel studies of the CUP1 array, I showed that instability at both tandem arrays can be induced by DNA replication stress and altered transcription of the locus. Importantly, while changes in instability in response to stress are observed within a few cell divisions, a change in steady state repeat copy number requires selection. Further, H3K56 acetylation is required for regulating transcription and transcription-induced instability at the CUP1 array, and, importantly, it restricts transcription-induced amplification of the CUP1 array. My work suggests that the modulation of replication and transcription is a simple, reversible strategy to alter instability at tandem repeats in response to environmental stimuli, which provides cells rapid adaptability through copy number variation. Additionally, histone acetylation may function to promote the normal adaptive program in response to transcriptional stress. Given the ubiquity of DNA replication, transcription, and chromatin marks like histone acetylation, the mechanisms I have characterized could significantly advance our understanding of the behavior of other tandem repeats and their role in shaping eukaryotic genomes.
Unsupervised Toxoplasma gondii Recognition by Fuzzy Cycle Generative Adversarial Network

Toxoplasma gondii , one of the world’s most common parasites, can infect all types of warm-blooded animals, including one-third of the world’s human population. Most of current routine methods of diagnosis are costly, time-consuming, and labor-intensive. The parasite can be directly observed under the microscope in tissue or spinal ﬂuid samples, and this form of testing is cheap, but used less frequently because of the difﬁculty in operation, and needs well trained professionals. Never-theless, observation of parasites in patient or animal specimens under the microscope is still performed by a large number of laboratories. The identiﬁcation of Toxoplasma parasite with cost-effectiveness solution is still a health challenge in developing countries. Here, we propose an Ar-tiﬁcial Intelligence (AI)-powered microscopic image analysis method for Toxoplasma gondii . The method uses Fuzzy Cycle Generative Adversarial Network (FCGAN) with transfer learning, by applying knowledge gained by the parasitologists that Toxoplasma gondii is in banana or crescent shaped form. Our approach aims to build connection between micro and macro associated objects by embedding fuzzy C-means cluster algo-rithm into Cycle GAN. We show the high accuracy and effectiveness of our approach in the newly collected 28,130 unlabeled microscopic images from Toxoplasma infection samples.
Closed Flap Osseous Crown Lengthening Procedure

Osseous crown-lengthening is often needed to enhance the appearance of a patient’s smile, prevent the violation of biologic width, and/or provide sufficient tooth structure for the placement of final restorations. The present technique for osseous crown lengthening typically involves flap surgery, a procedure that frequently is associated with postoperative complications that can interfere with the aesthetic outcome, such as infection, bleeding, and change in tissue position during the healing process. The erbium laser enables the clinician to offer the patient a minimally invasive alternative to osseous crown lengthening negating the adverse effects associated with conventional treatment. Other advantages of using the laser for osseous crown lengthening includes: hemostasis, improved visualization, fewer postoperative complications and recession.
Hemoparásitos de guacamayas, loros, pericas, cotorras y tucanes del Centro de Rehabilitación de Fauna Silvestre ARCAS, Petén, Guatemala

El presente estudio contribuyo a generar informacion sobre las relaciones entre los hemoparasitos y sus hospederos aves. Con el objeto de determinar la presencia de hemoparasitos y la relacion de estos con sus hospederos aves, se tomaron muestras de sangre de 76 aves; de las cuales, eran de la especie Amazona autumnalis, 6 de Amazona farinosa, 16 de Amazona albifrons (12 hembras y 4 machos), 13 de Pionus senilis, 3 de Aratinga astec, 10 de Ara macao, 7 de Ramphastos sulphuratus (5 machos y 2 hembras). No se observaron hemoparasitos en ninguno de los frotes. Dado que no es parte del protocolo medico del centro de rehabilitacion la administracion de medicamentos contra hemoparasitos, la ausencia de hemoparasitos tendria una explicacion ecologica que podria incluir: 1. Ausencia del vector. 2. Los vectores que se encuentran a nivel de sotobosque no son los mismos que hay a nivel de dosel. 3. Resistencia de las aves a los hemoparasitos. 4. El tipo de muestreo (vertical) no logro captar la fase de parasitemia. 5. No hay en el area, aves silvestres reservorias de los hemoparasitos de las aves muestreadas.
Amyand’s Hernia: Case Report

Amyands hernia is vermiform appendix in inguinal hernia.This usually presents as an unexpected intraoperative finding. Case Report: A 21 year old male had right inguinal hernia.Diagnosis of Amyands hernia was made introperatively.Appendix was entering through deep ring lying outside hernia sac.Appendectomy with herniorraphy done Conclusion: Appendix lying outside sac in Amyands hernia is rare.Adhesions of appendix with hernia sac leads Incaceration .
Conception d’un microsystème pour l’évaluation du passage de biomolécules à travers la barrière pulmonaire

La voie pulmonaire suscite un interet grandissant pour l’administration systemique des peptides et proteines therapeutiques, aujourd’hui encore administres essentiellement par voie parenterale. Un microsysteme a ete concu pour permettre de faciliter et accelerer les etudes in vitro de criblage de differentes biomolecules actives et de selectionner les formulations les plus adaptees a leur penetration a travers l’epithelium pulmonaire, en vue de selectionner les meilleurs candidats a une administration par voie pulmonaire. Organise en deux configurations distinctes, ce microsysteme permet dans un premier temps d’obtenir des barrieres epitheliales pulmonaires polarisees et jointives (cellules Calu-3) en seulement 7 jours dans des micropuits de 1mm², sans avoir a renouveler le milieu nutritif ni avoir recours a un appareillage externe associe au microsysteme. Grâce a la mise au point d’une technique simple de fabrication, des plateformes de culture contenant jusqu’a 12 micropuits en parallele sont aujourd’hui fabriquees de maniere standardisee. L’evaluation du passage de molecules est ensuite realisee sous une deuxieme configuration dediee a la mesure de la permeabilite des barrieres epitheliales cultivees en micropuits. La capacite de differents candidats (nanoparticules et biomolecules) a traverser l’epithelium pulmonaire a ete etudiee. Le passage de nanoparticules de PLGA revetues de chitosane ainsi que le passage de l’insuline ont ete demontres avec succes. Enfin, l’electrophorese capillaire couplee a une detection par fluorescence induite par laser (EC-LIF), compatible avec les faibles volumes manipules dans ce microsysteme, a ete exploitee pour la detection et la quantification de l’insuline apres passage des barrieres pulmonaires miniaturisees. A cette fin, l’insuline a soit ete marquee par le FITC, soit complexee a un anticorps ou a un aptamere fluorescents. A l’heure actuelle, seule la methode developpee pour le marquage de l’insuline par le FITC est utilisable a des fins de quantification, mais le recours a un aptamere a montre des premiers resultats encourageants.