Miracle-dz/UniFAR-FTUs huggingface dataset:
Comment aborder le sujet de la sexualité en consultation de médecine générale ? Enquête qualitative auprès de patientes à La Réunion

La sante sexuelle est un domaine de la sante qui a ete peu aborde en medecine generale. Les etudes quantitatives sur ce sujet ont decrit les freins et les leviers au discours sur la sexualite et mettaient en evidence les trois dimensions qui s’y rapportent : le physique, le psychique et le social. Aucune etude ne prenait en compte le discours des femmes qui consultent en medecine generale. Notre etude avait pour finalite de faire emerger le vecu et les representations des patientes pour comprendre comment aborder le sujet en consultation. Methode : l’etude transversale descriptive a utilise une approche qualitative par entretien individuel semi-dirige. Le guide d’entretien a ete elabore par l’enqueteur en fonction des donnees de la litterature medicale. Il abordait le theme de la relation medecin-patient, la sante, de la sante sexuelle. Le but etait de recueillir les informations necessaires a la comprehension des elements favorisant ou empechant l’abord de la sexualite en consultation. L’analyse du contenu du discours a ete fait entretien par entretien. Le recrutement a ete fait majoritairement par une approche directe des patientes en consultation. Resultats : 18 patientes de La Reunion ont ete interviewees entre octobre 2013 et janvier 2014 en cabinet de medecine generale. Pour que la sexualite puisse etre abordee en consultation, une trouble devait etre present, avoir un retentissement sur la sexualite de la femme et/ ou du couple. La relation avec son medecin devait etre suffisamment etablie pour pouvoir explorer l’intimite de la personne, elle dependait de la personnalite des patientes et des medecins. Le sens que chacune accordait dans sa vie a la sexualite et en particulier au sein d’un couple etait l’element important pour la sexualite feminine. Les symptomes comme les metrorragies, la baisse de la libido et les dyspareunies sont apparus et ont permis de mettre en evidence de evenements specifiques de la vie d’une femme pour que le medecin puisse investiguer leur sexualite. Ces moments propices ont ete la menopause, l’arrivee des enfants, la prevention autour de la contraception, la reprise de l’activite sexuelle, la presence d’une maladie chronique et le vieillissement. Conclusion : cette enquete aura permis de mettre en relief l’importance de la relation dans le couple medecin patiente pour echanger sur la sante sexuelle en consultation. Le medecin generaliste devrait s’attacher a saisir l’opportunite de certaines situations pour aborder le sujet avec ses patientes. S’interesser a la sante sexuelle des personnes permettrait de considerer la personne et son histoire dans son environnement socio-culturel, educatif et conjugal.
Ectomesodermal Dysplasia Syndrome (Focal Dermal Hypoplasia)

Where does the fat come from? How does the fat get there? For half a century the accepted explanation for the dermal ectopic fat in this symptom complex has been the absence of or underdevelopment of the dermis with replacement by adipose tissue'-^ from multiple herniations of subcutaneous fat to fill the void! But careful study of evolution of early and late lesions suggests this concept is a major error. Attention has been focused on the changes in connective tissue. It has been suggested that there is a compromised growth potential of collagen, or there are fibroblastic abnormalities demonstrable by culture, or that fine collagen fibers are present. These are thought to reduce the amount of collagen and, thus, the dermal thickness (hypoplasia), allowing herniation of fat to a subepidermal location. But what is the evidence for a defect based on a decreased rate of collagen synthesis? Would a deficiency of collagen due to a fibroblastic defect or collagen damage, secondary to inflammation, stimulate a proliferation of fat cells to form a focus of only a few fat cells located exclusively about capillary loops of the papillary dermis, or fat cells with perivascular localization involving only the midreticular dermis in a clinically linear lesion? Must there be a collagen defect to explain the heterotopic fat? We think not. A dysplastic development of fat in subepidermal and mid-dermal sites appears to be a more reasonable explanation from our studies.
Locating the epidemic source in complex networks

A disease propagating in a community or a rumor spreading in a social network can be described by a contact network whose nodes are persons or centers of contagion and links heterogeneous relations among them. Suppose that a disease or a rumor originating from a single source among a set of suspects spreads in a network, how to locate this disease/rumor source? This problem is crucial and challenging in different fields of computer or social networks, which is made more difficult in many applications where we have access only to a limited set of observations. We study the problem of estimating the origin of a disease/rumor outbreak: given a contact network and a snapshot of epidemic spread at a certain time, root out the infection source. Assuming that the epidemic spread follows the usual susceptible-infected (SI) model, we introduce an inference algorithm based on sparsely placed observers. We present an algorithm which utilizes the correlated information between the network structure (shortest paths) and the diffusion dynamics (time sequence of infection). The numerical results of artificial and empirical networks show that it leads to significant improvement of performance compared to existing approaches. Our analysis sheds insight into the behavior of the disease/rumor spreading process not only in the local particular regime but also for the whole general network.
Phosphatidic acid induces calcium influx in neutrophils via verapamil‐sensitive calcium channels

Phosphatidic acid (PA) induces a biphasic Ca2+ mobilization response in human neutrophils. The initial increase is due to the mobilization of Ca2+ from intracellular stores, whereas the secondary increase is due to the influx of Ca2+ from extracellular sources. The present investigation characterizes PA‐induced Ca2+ influx in neutrophils. Depolarization of neutrophils by 50 mM KCl enhanced PA‐induced Ca2+ influx, whereas verapamil, a Ca2+ channel blocker, attenuated this response in a dose‐dependent manner. These observations suggest that PA‐induced Ca2+ influx is mediated via verapamil‐sensitive Ca2+ channels. Stimulation of neutrophils with exogenous PA results in accumulation of endogenously generated PA with a time course similar to the effects of exogenous PA on Ca2+ influx. Ethanol inhibited the accumulation of endogenous PA and calcium mobilization, indicating that activation of membrane phospholipase D plays a role in PA‐mediated Ca2+ influx. The results of this study suggest that exogenously added PA stimulates the generation of intracellular PA, which then mediates Ca2+ influx through verapamil‐sensitive Ca2+ channels. J. Cell. Biochem. 78:297–304, 2000. © 2000 Wiley‐Liss, Inc.
Long-term angiographic follow-up of intracranial aneurysms treated with the intracranial neuroform stent reconstruction

Introduction: The long-term results of intracranial aneurysms treated with a Neuroform stent have been not reported. This study was to investigate the long-term evolution of intracranial aneurysms treated with the Neuroform stent and in-stent stenosis. Materials and Methods: Fifty-one patients with sixty-four intracranial aneurysms underwent Neuroform stent deployment over ten years. Angiographic data were compared before treatment and at each followup. Results: Forty-six aneurysms were treated with stent-assisted coiling while eighteen with stent deployment alone, with a total procedure-related complication rate of 6.7%. Immediate occlusion of the forty-six aneurysms with stent-coiling was complete in thirty-four aneurysms (73.9%), near complete in ten (21.7%) and incomplete in two (0.4%). During follow-up of 89 months (mean 52), twenty-three (71.9%) of 32 aneurysms with initial complete occlusion and follow-up remained completely occluded while nine (28.1%) recurred. Among ten aneurysms with initial near complete occlusion, one remained unchanged, four recurred and were re-treated to complete occlusion, and the other five had progressive thrombosis to complete occlusion. All fifteen aneurysms with stenting alone decreased in size with eight aneurysms completely disappeared. Progressive thrombosis occurred in twenty-two cases (81.5%) and of forty-two aneurysms with complete or near complete occlusion, recurrence occurred in thirteen cases (31%). Mild asymptomatic in-stent stenosis was present in three cases (5.3%). Conclusion: Stent reconstruction is safe in treating intracranial aneurysms with mild in-stent stenosis rate at long-term follow-up.
Genetic Engineering of Algae for Enhanced Biofuel Production

ABSTRACT There are currently intensive global research efforts aimed at increasing and modifying the accumulation of lipids, alcohols, hydrocarbons, polysaccharides, and other energy storage compounds in photosynthetic organisms, yeast, and bacteria through genetic engineering. Many improvements have been realized, including increased lipid and carbohydrate production, improved H2 yields, and the diversion of central metabolic intermediates into fungible biofuels. Photosynthetic microorganisms are attracting considerable interest within these efforts due to their relatively high photosynthetic conversion efficiencies, diverse metabolic capabilities, superior growth rates, and ability to store or secrete energy-rich hydrocarbons. Relative to cyanobacteria, eukaryotic microalgae possess several unique metabolic attributes of relevance to biofuel production, including the accumulation of significant quantities of triacylglycerol; the synthesis of storage starch (amylopectin and amylose), which is similar to that found in higher plants; and the ability to efficiently couple photosynthetic electron transport to H2 production. Although the application of genetic engineering to improve energy production phenotypes in eukaryotic microalgae is in its infancy, significant advances in the development of genetic manipulation tools have recently been achieved with microalgal model systems and are being used to manipulate central carbon metabolism in these organisms. It is likely that many of these advances can be extended to industrially relevant organisms. This review is focused on potential avenues of genetic engineering that may be undertaken in order to improve microalgae as a biofuel platform for the production of biohydrogen, starch-derived alcohols, diesel fuel surrogates, and/or alkanes.
Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder.

OBJECTIVE Obsessive-compulsive disorder (OCD) is highly heritable. Attempts to delineate precise genetic contributions have met with limited success. There is an ongoing search for intermediate cognitive brain markers (endophenotypes) that may help clarify genetic contributions. The aim was to assess inhibitory control processes in unaffected first-degree relatives of OCD patients for the first time with objective tests. METHOD The Intradimensional/Extradimensional Shift, Stop-Signal, and Cambridge Gamble tasks were administered to 20 unaffected first-degree relatives, 20 OCD patient probands with washing/checking symptoms, and 20 healthy matched comparison subjects without a family history of OCD. RESULTS Unaffected first-degree relatives and OCD patient probands showed cognitive inflexibility (extradimensional set shifting) and motor impulsivity (stop-signal reaction times). Decision making (Cambridge Gamble task) was intact. CONCLUSIONS Deficits in cognitive flexibility and motor inhibition may represent cognitive endophenotypes for OCD. Such measures will play a key role in understanding genotype/phenotype associations for OCD and related spectrum conditions.
Effect of regulatory warnings on antidepressant prescription rates, use of health services and outcomes among children, adolescents and young adults

Background: Regulatory bodies worldwide, including Health Canada, have issued warnings about prescribing antidepressants to children and adolescents. We sought to determine whether the Health Canada warning had the desired effects on prescribing patterns and outcomes and whether it had any unintended health consequences. Methods: We examined data from prescription and health care databases representing more than 265 000 children, adolescents and young adults annually to determine changes in the rates of antidepressant prescription, use of health services and outcomes in these populations in the 9 years before and the 2 years after the Health Canada warning. We also examined the data for unintended changes in these rates among patients with anxiety disorders. We used young adults as the comparison group because they were not targeted by the warning. Results: Following the warning, the rate of antidepressant prescriptions decreased among children and adolescents (relative risk [RR] 0.86, 95% confidence interval [CI] 0.81–0.91) and among young adults (RR 0.90, 95% CI 0.86–0.93). Ambulatory visits because of depression decreased among children and adolescents (RR 0.90, 95% CI 0.85–0.96) and young adults (RR 0.91, 95% CI 0.87–0.96). The rate of completed suicides among children and adolescents rose significantly after the warning (RR 1.25, 95% CI 1.08–1.44; annual rate per 1000 = 0.04 before and 0.15 after the warning). There was no equivalent change in the rate of completed suicides among young adults (RR 1.01, 95% CI 0.93–1.10; annual rate per 1000 = 0.15 before and 0.22 after the warning). Among patients with an anxiety disorder, the prescription rates did not change among children and adolescents, except for a decrease in the use of selective serotonin reuptake inhibitors other than fluoxetine, but the rates among young adults changed similar to the pattern of changes in the overall prescribing of antidepressants. There was also a significant decrease in the rate of physician visits because of anxiety disorders among young adults after the warning. Interpretation: Health advisories and warnings issued by regulatory bodies may have unintended consequences on the provision of care, delivery of health services and clinical outcomes. Further efforts are required to ensure that health warnings do not result in unexpected harm.
International disease monitoring, October to December 2009

African swine fever outbreaks in the Caucasus region, and one in the Leningrad region Bluetongue virus serotype 4 (BTV-4) outbreaks in Morocco and Tunisia pose a threat to Spain and Portugal Feral pigeon with highly pathogenic avian influenza H5N1 in Russia Rift Valley fever in South Africa Continuing spread of West Nile virus in Italy These are among matters discussed in the international disease monitoring report for October to December 2009, prepared by Defra's Food and Farming Group, Global Animal Health
On the Neimark–Sacker bifurcation in a discrete predator–prey system

A two-parameter family of discrete models describing a predator–prey interaction is considered, which generalizes a model discussed by Murray, and originally due to Nicholson and Bailey, consisting of two coupled nonlinear difference equations. In contrast to the original case treated by Murray, where the two populations either die out or may display unbounded growth, the general member of this family displays a somewhat wider range of behaviour. In particular, the model has a nontrivial steady state which is stable for a certain range of parameter values, which is explicitly determined, and also undergoes a Neimark–Sacker bifurcation that produces an attracting invariant curve in some areas of the parameter space and a repelling one in others.
Ten Concepts for an eBusiness Collaborative Project Management Framework

Theory and frameworks that apply to ebusiness projects undertaken within a single authority are inadequate when organizations need to collaborate. Collaboration demands additional management effort. Project management needs to coordinate the three levels of participating organizations, virtual teams and representatives. Three project lifecycle management functions, which relate to collaboration formation, initiative development, and the take-up and implementation of ebusiness, create extra management challenges. Project management needs to focus on four “meta factors” derived from the critical success factors used by practitioners and identified by researchers. These “meta factors” are motivation, capability, communication and coordination. This summary paper proposes that these ten concepts (three levels, three lifecycle management functions and four “meta” factors) need to be addressed in a theoretical framework capable of supporting effective management of ebusiness collaborative projects, providing an understanding of outcomes and reducing failure.
Bridgeless PFC Cuk Derived Converter Fed BLDC Motor with PID and Fuzzy Logic Controller

A bridgeless single phase ac-dc rectifier based Cuk derived converter topology fed BLDC motor is proposed to improvepower factor at the AC mains near to the unity with low THD for PFC applications. It utilizes one control signal over the whole line cycle. In addition, the proposed converter exhibits low inrush current and low magnetic emissions as classical Cuk topology. The partial elimination of diodes in DBR in the bridgeless topology results in lower conduction losses as compared with conventional Cuk converter. The proposed method is simulated in MATLAB/Simulink with PID and fuzzy logic controller for precise speed control. Simulation results are presented along with the theoretical analysis.
Nutrition and L and K-enteroendocrine cells

Purpose of reviewThe review highlights the influence of nutrients over the secretion of several hormones produced by enteroendocrine cells in the gastrointestinal tract that secrete incretin hormones. These hormones influence glucose homeostasis; food intake; gastric, pancreatic and hepatic secretions; and gastric and intestinal motility, and these aspects are summarized in this review. Recent findingsThis study provides an overview of recent advances in our understanding of the physiology of the incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as of oxyntomodulin. A better understanding of the secretion and action of these hormones at their receptors was made possible by new techniques that allow investigation of individual enteroendocrine cells. SummaryThe better understanding of the function of the gastrointestinal incretin hormones and their implications for improving glucose homeostasis and perhaps influencing food intake and appetite as well, new research in this area will help combat metabolic diseases such as type 2 diabetes and obesity.
A multi-physics model for microwave heating in metal casting applications embedding a mode stirrer

Microwave heating can be employed to improve the metal casting process. However, the usage of microwave ovens for casting imposes some specific problems which do not occur in conventional heating processes. In this paper, an approach is described in which a mechanical mode stirrer is used to provide a homogeneous electromagnetic field, while the heat input is controlled by the placement of susceptors. Due to the temperature dependency of the dielectric parameters a multi-physics model has been developed for the solution of the electro-thermal problem. A statistical method is implemented to include the rotating mode stirrer in the model. The results of the simulation are validated by experiments in order to create a simulation environment for the development of a microwave furnace casting process.
The Themes of Power and Trust in EDI Relationships

Dissertation: "Management Information Systems, Communications and Intraorganizational Power: An Integrative Study, a longitudinal study of the impact of an MIS providing registration-related information upon power distributions and interdepartmental communication in a university setting. Duties included implementing a major undergraduate curriculum change, working with doctoral students, and recruiting. Duties included implementing a major undergraduate curriculum change, establishing a doctoral program, and recruiting.
Emoballoon: A balloon-shaped interface recognizing social touch interactions

People often communicate with others using social touch interactions including hugging, rubbing, and punching. We propose a soft social-touchable interface called “Emoballoon” that can recognize the types of social touch interactions. The proposed interface consists of a balloon and some sensors including a barometric pressure sensor inside of a balloon, and has a soft surface and ability to detect the force of the touch input. We construct the prototype of Emoballoon using a simple configuration based on the features of a balloon, and evaluate the implemented prototype. The evaluation indicates that our implementation can distinguish seven types of touch interactions with 83.5% accuracy.
Influence of Processing Methods on Protein Quality of Atlantic Horse Mackerel (Trachurus trachurus)

Protein quality is a long-accepted paradigm for human protein needs however the quality is affected with processing methods. The protein and amino acids content of poached or charcoal or wood smoked horse mackerel fish (HMF) were determined using standard methods. Chemical analyses were carried out on the processed fillet and skin, head and bone (SHB) diets under standard conditions. A total of 40 weaned male rats were fed with processed fillet or SHB diets for 12 days to assess protein quality and amino acids digestibility. Fish samples were also analyzed for protein efficiency ratio (PER), net protein ratio (NPR), Protein Digestibility-Corrected Amino Acid Scores (PDCAAS), true and apparent protein digestibility (TPD and APD). Results showed that the wood smoked fillet had the highest PDCAAS regarding to the controls whereas PER, NPR and TPD was highest in SHB. The best results were obtained from animals fed on coal or wood smoked fillet/SHB on protein quality and amino digestibility parameters selective. The SHB could be used as a valuable source of ingredients for animal feeds and human consumption instead of being discarded as agricultural waste. Keywords: Processing methods , protein quality, growth performance; amino acids, Atlantic horse mackerel, agricultural waste/discard.
Intervention to Improve Expository Reading Comprehension Skills in Older Children and Adolescents with Language Disorders

With the recent renewed emphasis on the importance of providing instruction to improve expository discourse comprehension and production skills, speech–language pathologists need to be prepared to implement effective intervention to meet this critical need in older children and adolescents with language disorders. The purpose of this review article is to present intervention techniques, approaches, and strategies for facilitating expository reading comprehension skills in older children and adolescents with language disorders, as reported in the research literature. Evidence supports both content and strategic approaches to facilitating reading comprehension of expository text in these students.