Miracle-dz/UniFAR-FTUs huggingface dataset:
Analytical optimization of inset permanent magnets machine based on a genetic algorithm

In this work, we present a torque optimization of the inset permanent magnet synchronous machine. The optimization system combines an analytical model used to calculate the air-gap flux density as well as the direct-axis and quadratic-axis inductances, with a genetic algorithm. Results of the torque optimization and the torque reported to the volume of the magnet are presented.
Order reduction for roesser state-space model based on real jordan transformation

This paper is concerned with the problem of a order reduction approach for Roesser state-space model of multidimensional (n-D) systems based on real Jordan transformation. It will be shown that even if the eigenvalues of main block diagonal matrices of coefficient matrix A are not all real, it is still possible to reduce the order of the given Roesser model based on a real n-D Jordan canonical form obtained by using a well-defined real similarity transformation or intermediate matrix. As a consequence, the limitation of the existing elementary operation order reduction approach with Jordan transformation can be overcome so that it can be viewed as a special case of the new proposed approach. Moreover, a basic order reduction procedure is presented and corresponding examples are provided to illustrate the details as well as the effectiveness of the proposed approach.
Antiproliferative Activity of Larrea Divaricata Cav. on Lymphoma Cell Line: Participation of Hydrogen Peroxide in Its Action

ABSTRACT Larrea divaricata is a plant used in Argentina. The aim was to analyze the participation of H2O2 in the antiproliferative effect of L divaricata on BW5147 cells. Different studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen reducing activity, NF-κ B translocation, H2O2 production, H2O2 scavenging activity, and effect on exogenous superoxide dismutase. The extract decreased proliferation and induced apoptosis through P-38 and ERK pathways. The extract activated Mn2 +–SOD, increasing H2O2, which was implicated in the antiproliferative mechanism by the increase of Nitric oxide (NO). New drugs, which can increase H2O2, could be a therapeutic strategy for the treatment of cancer.
Risk Factors for Pertussis Among Hispanic Infants: Metropolitan Portland, Oregon, 2010–2012

Background: In 2012, Oregon observed its highest numbers of reported pertussis cases since 1953. The greatest morbidity occurred among infants <6 months of age, with higher rates among Hispanics than non-Hispanics. To explain this disparity, we analyzed pertussis surveillance data. Methods: An analysis was conducted among infants <6 months of age in the Portland metropolitan area during 2010–2012. Characteristics examined were ethnicity (Hispanic or non-Hispanic), household size (>4 or ⩽4 persons), pertussis vaccination status (upto-date or not up-to-date for age), child care center attendance (yes or no), infant birth weight (<2500 or ≥2500 g) and maternal age (<20 or ≥20 years). Results: Eighty-two infants <6 months of age with pertussis were identified. Twenty-eight case-infants (34%) were Hispanic, and 54 (66%) were non-Hispanic. By ethnicity, infants with pertussis were similar in illness confirmation method, sex, age, hospitalization status, vaccination status, child care center attendance, infant birth weight and maternal age. Hispanic infants were more likely than non-Hispanic infants to live in households with >4 persons. Univariate analysis showed Hispanic infants had approximately 2.3 times the risk for pertussis, compared with non-Hispanic infants, and infants living in households >4 persons had approximately 2.4 times the risk for illness, compared with those in households with <4 persons; stratified risk ratios did not differ between Hispanic (2.4; confidence interval: 1.0–5.7]) and non-Hispanic infants (2.0; confidence interval: 1.2–3.5). Conclusions: A household size of >4 persons is a potential risk factor for pertussis; the magnitude of this risk is similar for Hispanic and non-Hispanic infants.
P3K-3 Investigation of Low Glass Transition Temperature Epoxy Resin Blends for Lossy, yet Machineable, Transducer Substrates

In the context of our on-going investigation of low-cost two-dimensional (2D) arrays, we studied the temperature-dependent acoustic properties of epoxy blends that could serve as a component in a lossy backing for a compact 2D transducer array. The acoustic impedance and attenuation of five epoxy blends - ranging from "soft" (low Tg) to "hard" (high Tg) - were analyzed across a 35degC temperature range. Fiberglass- and tungsten-filled samples were also fabricated and tested. We established that the hardest epoxy has a constant impedance (versus temperature) of 2.2 MRayl and constant attenuation of 1 dB/mm, while the softer epoxies are more temperature dependent. One soft epoxy has an impedance that declines from 2.7 to 2.0 MRayl and attenuation that increases from 5 to 10 dB/mm. In our application, unfilled epoxies could provide a 24 dB attenuation of backing block echoes, while filled epoxies may provide up to 40 dB attenuation. These materials may be machined (when chilled) or molded to form compact Z-axis conductive backing blocks with improved attenuation of echoes using existing methods.
Analysis of a null mutation in the Drosophila splicing regulator Tra2 suggests its function is restricted to sexual differentiation

Tra2 is a regulator of pre‐mRNA splicing and a key component of the Drosophila somatic sex determination pathway. Functional orthologs of this protein are thought to perform nonsex‐specific functions essential for viability in both vertebrates and nematodes. Although Drosophila Tra2 is expressed throughout the soma of both sexes, studies on it have focused only on the sex‐specific phenotypes of known viable alleles. Here we show that that widely used tra2 mutant alleles have residual activity and are not suitable for evaluating its effect on viability. To test whether Tra2 has an essential role in development, we generated a transposon‐induced deletion in critical coding sequences. We find that tra2 deletion adults can survive as well as their heterozygous siblings. Thus, in contrast to other organisms, Tra2 is not required in Drosophila for general viability under laboratory conditions. genesis 37:76–83, 2003. © 2003 Wiley‐Liss, Inc.
Importance of Indigenous Breeds of Chicken for Rural Economy and Their Improvements for Higher Production Performance

Indigenous/native breeds of chickens are playing an important role in rural economies in most of the developing and underdeveloped countries. They play a major role for the rural poor and marginalised section of the people with respect to their subsidiary income and also provide them with nutritious chicken egg and meat for their own consumption. Performance of native fowl can be improved by change in husbandry, feeding, and better health cover. However, genetic improvement may be made either through selection and crossbreeding or by utilisation of both selection and crossbreeding. Improvement through selection may be time consuming but the improvement will be permanent. Through crossbreeding improvement may be faster but research has to aim for the production of native-type birds with higher production potential. In the present review efforts have been made to present the importance of native fowl to rural economy and their improvement for higher production performance.
Selective Control of Skeletal Muscle Differentiation by Akt1*

The phosphatidylinositol 3-kinase-Akt pathway plays a central role in growth, development, and metabolism in both normal and neoplastic cells. In skeletal muscle, Akt has been implicated in regulating regeneration and hypertrophy and in counteracting atrophy. Here we provide evidence that Akt1 and not Akt2 is essential for muscle differentiation. Using a robust model of MyoD-mediated muscle development, in which dominant-negative Akt blocked differentiation, we show that targeted loss of Akt1 was equally inhibitory. Selective elimination of Akt1 had no effect on myoblast viability or proliferation but prevented differentiation by impairing the transcriptional actions of MyoD. In contrast, knockdown of Akt2 had no effect on myoblast survival or differentiation and minimally inhibited MyoD-regulated transcription. Our results define isoform-specific Akt-regulated signaling pathways in muscle cells that act through Akt1 to sustain muscle gene activation and promote differentiation.
CT-guided thoracic biopsy: evaluating diagnostic yield and complications.

INTRODUCTION This study retrospectively evaluated CT-guided thoracic biopsies for diagnostic yield, accuracy and complications. MATERIALS AND METHODS A retrospective analysis of 384 patients (mean age 62.7 years; male/female = 251/133) who underwent 399 CT-guided thoracic biopsies were performed for evaluating diagnostic yield, accuracy and complications. Correlations between patients age, procedure factors (biopsy-needle size, number of passes, lesion-size, lesion-depth and traversed lung-length) and complications such as pneumothorax, haemothorax and haemoptysis were evaluated. A comparison between fine needle aspiration (FNA) group and core ± FNA group for diagnostic yield and complications was also performed. RESULTS FNA was performed in 349 patients and core ± FNA in 50 patients. The biopsy samples were adequate in 91.9% and the diagnostic accuracy for malignant lesions was 96.8% with 95.7% sensitivity and 100% specificity. Pneumothorax (detected on CT) occurred in 139 cases (34.8%) and only 12 (3.0%) required insertion of an intercostals drain. Mild haemoptysis occurred in 13 patients (3.2%) and small haemothoraces in 2 patients. Pneumothorax occurrence was significantly associated with the traversed lung-length (>3mm), lesion-size (≤33 mm) and lesion-depth (≥60mm) (P <0.05). Haemoptysis occurrence was also significantly associated with traversed lunglength (>3mm) and lesion-size (≤33 mm) (P <0.05). There was no significant difference between diagnostic yield and complication rate between FNA and core ± FNA groups. CONCLUSION CT-guided thoracic biopsy is a safe procedure with high diagnostic yield and low risk of significant complications. Traversed lung-length and smaller lesion size are associated with occurrence of pneumothorax and haemoptysis.
Espacios de aprendizaje en las comunidades de prácticas: el caso de las asociaciones de jóvenes arquitectos

Este estudio ha revisado la teoria sobre comunidades de practicas y espacios de aprendizaje aplicado a la realidad de jovenes profesionales que colaboran entre si para adquirir experiencia y compartir su banco de ideas en concursos de obras. Estamos ante un caso en el que la profesion se esta redefiniendo y cobran protagonismo las relaciones de aprendizaje y refuerzo mutuo. Nos hemos centrado en la revision de casos de asociaciones de jovenes arquitectos espanoles, seria conveniente ir ampliado la muestra a otro tipo de profesiones.
Speckle reduction in double-pass retinal images using variable-focus lenses

Speckle arises in double-pass images when coherent light is scattered by the retina. Since this noise degrades the images that are used to characterize the eye, there is special attention in reducing speckle when working with instruments based on retina reflections. In this work, we present a method for speckle reduction in double-pass retinal images by producing minor periodic variations in the vergence of the beam entering the eye with a variable-focus lens during image recording. Measurements in an artificial and a real eye following the implementation of the method corroborate the speckle reduction.
Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease

Kawasaki disease (KD) is an acute illness of early childhood characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and nonsuppurative lymphadenopathy. The histopathological findings in KD comprise panvasculitis with endothelial necrosis, and the infiltration of mononuclear cells into small and medium‐sized blood vessels. The levels of many proinflammatory cytokines, chemokines and adhesion molecules can be elevated in sera from children with KD at the acute stage. Although many immunological studies on KD involving peripheral blood have been reported, the data obtained remain controversial. This review focuses on the immune response of peripheral blood lymphocytes and monocytes/macrophages during acute KD.
Diagnosis of Periprosthetic Joint Infections of the Hip and Knee

&NA; No preferred test for diagnosis of periprosthetic joint infection exists, and the algorithm for the workup of patients suspected of infection remains unclear. The work group evaluated the available literature to determine the role of each diagnostic modality and devise a practical algorithm that allows physicians to reach diagnosis of periprosthetic joint infection. Ten of the 15 recommendations have strong or moderate evidence in support. These include matters involving erythrocyte sedimentation rate and C‐reactive protein level testing, knee and hip aspiration, and stopping the use of antibiotics prior to obtaining intra‐articular cultures. The group recommends against the use of intraoperative Gram stain but does recommend the use of frozen sections of peri‐implant tissues in reoperation patients in whom infection has not been established, as well as multiple cultures in reoperation patients being assessed for infection. The group recommends against initiating antibiotic treatment in patients with suspected infection until after joint cultures have been obtained, but recommends that prophylactic preop‐erative antibiotics not be withheld in patients at lower probability for infection.
Subspace compressive GLRT detector for airborne MIMO Radar

In this paper, the design of a subspace compressive GLRT (SSC-GLRT) detector has been pursued for MIMO airborne radar system when the secondary sets of data are available in addition to the primary one. It is observed that with very reduced amount of measurement data at sub-Nyquist rate that is equal to the number of virtual bi-static radar in the presence of a single target, SSC-GLRT provides the same performance as the conventional GLRT with much larger length of the data, i.e., an order of magnitude higher given by the product of the number of elements in the received antenna array and coherent pulse interval (CPI). Therefore, SSC-GLRT is much energy efficient and useful in the scenario where the computational complexity becomes a burden. Also, this paper illustrates an elegant way of mapping the angular and Doppler domain to an one dimensional discrete vector for the formulation of compressive sampling (CS) based ℓ1 reconstruction of the signal subspace when it is unknown so that it can successively be used in SSC-GLRT. The simulation example further corroborates the effectiveness of the proposed SSC-GLRT detector.
Cyclin D1 inhibits cell proliferation through binding to PCNA and cdk2.

Cyclin D1 is known as a promoting factor for cell growth. We previously showed, however, that the expression of cyclin D1 increases markedly in senescent human fibroblasts in vitro. Here we investigate whether the overexpression of cyclin D1 inhibits cell proliferation. Colony formation after transfection with the cyclin D1 expression vector was repressed in NIH-3T3, TIG-1, CHO-K1, and HeLa cells, compared with those with mock and cyclin E expression vectors. A transient transfection assay demonstrated that the overexpression of cyclin D1 inhibited DNA synthesis of TIG-1 cells. The complexes of cyclin D1 with PCNA and cdk2 increased remarkably in senescent cells, compared with young counterparts. Excessive glutathione S-transferase (GST)-cyclin D1 inhibited DNA replication and repressed cdk2-dependent kinase activity in vitro. DNA synthesis of NIH-3T3 transfectants with PCNA or cdk2 expression vectors was not inhibited by the overexpression of cyclin D1. These results indicate that an excessive level of cyclin D1 represses cell proliferation by inhibiting DNA replication and cdk2 activity through the binding of cyclin D1 to PCNA and cdk2, as it does in senescent cells.
A statistical model of the interaction between reverberation fields and lossy materials

In this work, a thermodynamic model for random fields was used to study lossy materials in a reverberation chamber (RC). In particular, angular spectrum (AS) statistics were obtained inside the material and the deterministic alteration of the incidence angle at the boundary was used to find the probability density function (PDF) of the effective refraction angle. The statistical model was validated by a discrete approach and a semi-empirical model was derived to calculate the power transmitted inside a nested RC through an aperture covered by a lossy thin slab. A preliminary experimental result is presented in order to have a first check of the proposed formulation.
Lentiviral-mediated expression of SATB2 promotes osteogenic differentiation of bone marrow stromal cells in vitro and in vivo.

Special AT-rich sequence-binding protein 2 (SATB2 ) acts as a potent transcription factor to promote osteoblast differentiation and bone regeneration. In this study, we first used lentiviral-mediated gene transfer of Satb2 into mouse bone marrow stromal cells (BMSCs) and investigated the capacity of SATB2 overexpression to promote osteogenic differentiation in vitro and in vivo. We found that LV-Satb2 -transduced BMSCs produced SATB2 protein and underwent rapid and marked osteogenic differentiation, as demonstrated by increased expression of osteoblastic genes, including runt-related transcription factor 2 (Runx2), transcription factor Sp7 (Sp7), activating transcription factor 4 (Atf4), and bone sialoprotein (Bsp), and increased alkaline phosphatase activity and Alizarin Red S staining. To analyze the induction of bone formation in vivo, LV-Satb2-transduced BMSCs were implanted into the hindlimbs of syngeneic mice, with β-tricalcium phosphate as the scaffolding material. Four weeks after implantation, transduction with LV-Satb2 had greatly enhanced the formation of new bone. These data demonstrated the capacity of lentiviral-mediated SATB2 to promote the osteogenic differentiation of BMSCs in vitro and to enhance bone formation through a tissue-engineering technique that may be useful in bone-regenerative medicine.
Towards Quantitative Computer‐Aided Studies of Enzymatic Enantioselectivity: The Case of Candida antarctica Lipase A

The prospect for consistent computer‐aided refinement of stereoselective enzymes is explored by simulating the hydrolysis of enantiomers of an α‐substituted ester by wild‐type and mutant Candida antarctica lipase A, using several strategies. In particular, we focused on the use of the empirical valence bond (EVB) method in a quantitative screening for enantioselectivity, and evaluate both kcat and kcat/KM of the R and S stereoisomers. We found that an extensive sampling is essential for obtaining converging results. This requirement points towards possible problems with approaches that use a limited conformational sampling. However, performing the proper sampling appears to give encouraging results and to offer a powerful tool for the computer‐aided design of enantioselective enzymes. We also explore faster strategies for identifying mutations that will help in augmenting directed‐evolution experiments, but these approaches require further refinement.
Examining the Efficiency of Home Care

This article focuses on the “efficiency” or cost-effectiveness of home care. Because home care encompasses a range of services targeted to many populations, it is necessary to take cognizance of case mix and clarify its goals to assess effectiveness. Goals for home care can be thought of as meeting and/or compensating for client dependency needs or making a difference in the client’s clinical trajectory. The latter implies comparing actual to expected outcomes, where outcomes can cover a wide range of domains addressing quality of care and quality of life. Inferring the effect of treatment (i.e., home care) on various outcomes will likely rely heavily on epidemiological techniques that, in turn, rely on sophisticated statistical techniques. Problems measuring the costs of care include how to handle the costs of informal care and deciding whose costs should be of primary concern. Better data about the costs, and experimentation with different forms of caregiving, need to be pursued.
An incremental intelligent object recognition system based on deep learning

The accuracy of object recognition has been greatly improved due to the rapid development of deep learning, but the deep learning generally requires a lot of training data and the training process is very slow and complex. We propose an incremental object recognition system based on deep learning techniques and speech recognition technology with high learning speed and wide applicability. The system can learn from scratch through the way of human-computer interaction. Through the interaction of user, the system continues to improve its identification ability by updating or adding object's feature templates gradually. The types of objects that it can be identified become more and more, and recognition rate is also getting high increasingly. The GoogLeNet inception v4 network is used to extract the object features. Then the object is classified based on the extracted features by measuring the similarity between the object and its template. Experiments show that our system can identify the object accurately after the system learns about ten samples of this object. The self-learning system has a wide range of applicability and flexibility because of the incremental frame based on deep learning.
Lateralization of brain function in childhood revealed by magnetic resonance spectroscopy

We used proton magnetic resonance spectroscopy (sup 1 H MRS) for the assessment of focal brain pathology in 22 right-handed children with a diagnosis of intractable temporal lobe epilepsy, and we related this pathology to cognitive dysfunction. Cognitive assessment was based on measurements of verbal IQ, performance IQ, and the Paired Associate Learning subtest of the Wechsler Memory Scale. Five of the 22 children showed no abnormalities of the temporal lobes on1 H MRS, seven showed unilateral pathology, and 10 showed bilateral abnormalities. We found that left-sided pathology is associated with a loss of verbal cognitive functions, whereas right-sided pathology is associated with a loss of nonverbal functions. These findings are consistent with the pattern of lateralization of brain function that has been observed in adults. NEUROLOGY 1996;46: 974-977.