Miracle-dz/UniFAR-FTUs huggingface dataset:
Rodent 2-year cancer bioassays and in vitro and in vivo genotoxicity tests insufficiently predict risk or model development of human carcinomas

In 2018, the National Institutes of Health estimated that 1,735,350 new cancer cases were diagnosed in the United States and 609,640 patients died from various forms of cancer. The vast majority of those cancer deaths occurred from cancers derived from epithelial cells, that is, carcinomas. The most lethal cancers in American women based upon estimated deaths occurred in the lung and bronchus (352,209), breast (205,675), colon and rectum (123,617), pancreas (96,571), and ovary (71,141). The largest cancer killers in men occurred in the lung and bronchus (427,587), prostate (140,086), colon and rectum (135,542), pancreas (100,599), and liver (80,526). Histologically different carcinomas are initiated, clonally expanded, and progressed in association with particular changes in genes and also epigenetic alterations. Currently employed genotoxicity testing protocols emphasize testing for the initiating (mutational) potential of the test agent. While 2-year chronic rodent cancer bioassays test for the entire spectrum of carcinogenic transformation and development, the high doses used in these assays induce cytotoxicity leading to increased cellular proliferation rates and high false-positive rates of tumor induction in non-genotoxic chemicals. The low cancer induction from high radiation exposures experienced by atomic bomb survivors in Hiroshima and Nagasaki, Japan, and the epidemiological evidence showing that cigarette smoking duration and not intensity is associated with lung cancer risk both support a more important role for tumor promotion rather than initiation in the clinical presentation of human carcinomas. Cancer hazard assessment testing protocols and weight-of-the-evidence analysis of agent-specific cancer risk should be better aligned with the pathogenesis of human carcinoma.
Measurement Scale Development and Validation of Female Employees’ Career Expectations in Mainland China

This paper aimed to develop a measurement scale for female hotel employees’ career expectations. Both qualitative and quantitative research methodologies were applied. In-depth interviews were first conducted to collect primary data of career expectation activities, and then the main survey was conducted nationwide to collect representative data. After a series of exploratory factor analysis, two dimensions were extracted, namely career rewards and career development. The results of confirmatory factor analysis indicated that the measurement items developed were both reliable and valid. Of the two factors of female hotel employees’ career expectations, career rewards was an important factor. Both academic and practical implications were discussed to provide valuable insights for human resource management of hotels in China. The paper concludes with the discussion of limitation and suggestions for future research.
Rigidity and sharp stability estimates for hypersurfaces with constant and almost-constant nonlocal mean curvature

We prove that the boundary of a (not necessarily connected) bounded smooth set with constant nonlocal mean curvature is a sphere. More generally, and in contrast with what happens in the classical case, we show that the Lipschitz constant of the nonlocal mean curvature of such a boundary controls its {C^{2}} -distance from a single sphere. The corresponding stability inequality is obtained with a sharp decay rate.
Automatic Coordination of Internet-Connected Thermostats for Power Balancing and Frequency Control in Smart Microgrids

This paper proposes a novel feedback control strategy, so-called clock-like controller (CLC), to balance power supply and demand in smart microgrids by adjusting the setpoint temperatures of air conditioning (AC) loads. In the CLC algorithm, the grid operator communicates with the individual thermostats via the Internet and adjusts their setpoints by discrete temperature intervals (e.g., ±0.5 °C). Numerical simulations indicate that the proposed algorithm is able to deliver a smooth controllability of the aggregate AC power despite discrete temperature offsets. It can also be used for peak load shedding to mitigate the power generation cost. The CLC algorithm is then integrated into the grid frequency control problem, in which both power generators and loads in the network attempt to regulate the frequency of the system despite disturbances from demand, renewable sources, and local weather conditions. An autonomous microgrid model including a steam and a hydro generator, a solar energy source, and a large number of thermostatic loads is developed to evaluate and demonstrate the proposed method. Simulation results indicate that the AC loads with CLC algorithm can help maintain the power system frequency during extreme events when demand exceeds the maximum generation capacity available to the network. Under normal conditions, the contribution of demand-side control is marginalized by the fast responding generators, because of time delays in the frequency measurement and internet communication network.
Automatic landing of a low-cost quadrotor using monocular vision and Kalmanfilter in GPS-denied environments

Unmanned aerial vehicles are becoming an important part of the modern life. Despite some recent advances in GPS-aided navigation of quadrotors, the concern of crash and collision still overshadows their reliability and safety, especially in GPS-denied environments. Therefore, the necessity for developing fully automatic methods for safe, accurate, and independent landing of drones increases over time. This paper investigates the autolanding process by focusing on an accurate and continuous position estimation of the drone using a monocular vision system and the fusion with the inertial measurement unit and ultrasonic sensors' data. An ARUCO marker is used as the landing pad, and the information is processed in the ground station through a real-time Wi-Fi link. In order to overcome the closed loop instability caused by the communication and localization delays, we propose a method called "movement slicing method". This method divides the moves around the marker into moving and waiting slices and makes the landing process not only more accurate but also faster. Experimental results show a successful landing of the UAV on a predefined location, while it is accurately aligned with the marker using the proposed method.
A SYSTEM DYNAMICS APPROACH TO DOMESTIC REFRIGERATORS’ REPLACEMENT IN COLOMBIA

Upgrading refrigerators is one of the strategies for increasing energy efficiency in the residential sector in Colombia. We examine alternative policies for promoting the substitution of low efficiency for higher efficiency models that will reduce power consumption and CO2 emissions. The evaluated policies include increasing awareness of efficiency labels, rebates and tax reductions. We simulate the impact of these policies combining discrete choice and dynamic diffusion models. Our results show that simultaneous application of financial incentives and information programs over a 20 year period can reduce power consumption and carbon emissions by more than 174,000 GW/h and 50,000 Ton CO2 with respect to the current program.
Beetle Antennae Search Algorithm Based on PSO and Fibonacci

Beetle Antennae Search Algorithm (BAS) is simple and efficient, but is not stable. The calculation precision is not high and the algorithm is easy to get into local optimum. To overcome these defects, the idea of particle swarm is used to search and traditional Fibnacci method to determine the search step length of each set up, so as to propose the PSO-Fibonacci-BAS algorithm. In this paper, single peak and multi peak function are used to test the performance of PSO-Fibonacci-BAS and three evaluation criteria are established to evaluate the performance of the algorithm. The simulation results show that PSO-Fibonacci-BAS is better than PSO and BAS. The algorithm not only has strong stability, but also has high precision.
Tropical Teleconnections to Antarctic Sea Ice During Austral Spring 2016 in Coupled Pacemaker Experiments

Following a multidecade increase, Antarctic sea ice declined drastically during austral spring 2016. Suggested causes of the sea ice decline include lingering effects of the 2015/2016 extreme El Niño and a tropical Indian Ocean teleconnection to high‐latitude atmospheric circulation. Here, we conduct pacemaker experiments using a full coupled climate model forced with observed tropical sea surface temperature to examine the impact of the Indian and Pacific Oceans on southern high latitudes during spring 2016. Our experiments suggest that a Rossby wave teleconnection from the tropical Indian Ocean contributed to the sea ice decline during spring 2016, with less influence from the Pacific Ocean. However, we find considerable spread in the magnitude of sea ice anomalies across ensemble members, suggesting that while an Indian Ocean teleconnection likely played a role, intrinsic atmospheric variability and high‐latitude ocean conditions may also have been important in driving the observed 2016 spring sea ice decline.
Production and Identification of Interspecific Hybrids between Pepper (Capsicum annuum L.) and the Wild Relative (Capsicum frutescens L.)

Wild pepper (Capsicum frutescens L.) could be a source of variation to improve cultivated pepper due to its unique traits with adapting challenges caused by adversity. Interspecific hybridization has been used as an effective way of pepper introgression breeding, which transfers genes of interest from wild relatives to cultivated crops. Here, eight fertile hybrids F1 were produced from pepper (Capsicum annuum L.) and the wild relative (C. frutescens), as female and male, respectively, by interspecific hybridization. Interspecific hybrids were identified using conventional morphological descriptors and SSR molecular markers. The results showed that significant differences in agronomic traits existed among cultivated pepper, wild relatives, and interspecific hybrid F1. Interspecific hybrid F1 presented intermediate values, although they were closer to the wild species in most of the agronomic traits. Analysis of SSR markers clearly showed that interspecific hybrid F1 had bands from the paternal and maternal accessions, which indicated that F1 hybrid was heterozygous. Our results provide hybrid for breeder to transfer genes of interest from wild relative, C. frutescens, to cultivated pepper, which is an important step for introgression breeding. _____________________________________________________________________________ 1 State key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Vegetables, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, People Republic of China. * Corresponding author; e-mail: wanhongjian@sina.com 2 Jiangsu Coastal Area Institute of Agricultural Sciences, Yancheng, People Republic of China. 3 College of Agricultural, Yunnan University, Kunming, Yunnan, People Republic of China.
The infiltration of inflammatory cells in the formation of sarcoid granulomas

Sarcoidosis is considered the archetype of immune granulomatous disorders, since immunoregulatory mechanisms that play a part in the development of the sarcoid granuloma may modulate pathogenetic events leading to granuloma development in other granulomatous diseases [1]. Remarkable advances have been made in understanding general immunological and molecular aspects of the mechanisms leading to granuloma formation and the development of fibrosis in sarcoidosis. In particular, the sarcoid granuloma is considered to be the consequence of a crippled immunological response against an unidentifed antigen that has persisted at sites of disease involvement, perhaps because of its low solubility and degradability. Indeed, although hypersensitivity reactions commonly resolve, the balance between events that mediate resolution or perpetuation of inflammatory responses may be altered in patients with chronic sarcoidosis. The persistence of the aetiological agents and/or an imbalance of mechanisms for the removal of inflammatory cells and their by-products ultimately lead to an ongoing inflammatory response. As a result, cytokines with pro-inflammatory destructive biological functions are locally produced; overall, these cytokines set the stage for the development of irreversible remodelling of lung tissue, progression toward pulmonary granuloma formation, and, in some individuals, irreversible development of pulmonary fibrosis. The aim of the present chapter is to provide an overview of the available knowledge concerning the mechanisms leading to the inflammatory processes that occur at common sites of involvement in sarcoidosis. A detailed description of the cellular interactions that govern the dynamics of granuloma formation is also included.
Genome sequence of Streptomyces antioxidans MUSC 164T isolated from mangrove forest

Members of Streptomyces genus are well known to produce bioactive compounds of various 26 structures[1-3]. Having a complicated development life cycle with the ability to form spores, 27 Streptomyces species are ubiquitous in nature and can be found in interesting places like deep 28 sea, hot springs and also mangrove forest[3-11]. Streptomyces antioxidans MUSC 164T was 29 originally isolated from mangrove forest in the east coast of Peninsular Malaysia and has been 30 deposited at two culture collection centers (=DSM 101523T = MCCC 1K01590T)[12,13]. After 31 rounds of in vitro screening using human neuronal cell line (i.e. SH-SY5Y), the extract of 32 MUSC 164T was found to possess significant neuroprotective effect against hydrogen 33 peroxide[13]. Here we report the high quality genome sequence of MUSC 164T, while 34 discussing its genome potential to produce pharmaceutically important compounds.
EMOTIONAL INTELLIGENCE AMONG LITHUANIAN AND LATVIAN STUDENT ATHLETES

Background. This article deals with the issue of the manifestation of emotional intelligence in Lithuanian and Latvian student athletes. Emotional intelligence has been suggested as providing a new perspective on how emotional competencies necessary for performance in today’s workplace among would-be physical educators might be more effective and better understood. Hence, the following research question is raised: does the emotional intelligence of Lithuanian student athletes differ from that of Latvian student athletes? We hypothesized that the emotional intelligence of Lithuanian student athletes differs from that of Latvian student athletes. Research aim was to reveal the manifestation of emotional intelligence in Lithuanian and Latvian student athletes. Methods. The independent random sample consisted of 227 student athletes from the Latvian Academy of Sports Education and 214 student athletes from the Lithuanian Sports University. Schutte Self-Report Inventory (SSRI) was employed. This instrument divides emotional intelligence into four separate components, namely: ability to use personal positive emotional experience (optimism), ability to assess and express emotions (appraisal), ability to understand and analyse emotions (social skills) and ability to manage emotions (utilization). Results. The analysis of the ability to use personal positive emotional experience resulted in the following averages: 51.48 ± 5.24 in case of the Lithuanian student athletes and 52.78 ± 6.33 in case of the Latvian student athletes. The application of the Student’s t-test revealed a statistically significant difference in the ability of the Lithuanian student athletes to use own positive emotional experience and that of the Latvian student athletes: t (439) = 2.32; p < . 005. Conclusions. The comparison of the components of emotional intelligence of Lithuanian and Latvian student athletes revealed that Latvian student athletes have better ability to use own positive emotional experience (optimism) (p < .05). No other statistically significant difference between Lithuanian and Latvian student athletes in terms of the components of emotional intelligence was observed.
Properties of Zinc Ferrite Nanoparticles Due to PVP Mediation and Annealing at 500°C

In contributing to the improvement of Ferrite Magnetic nanoparticles, the effects of Poly (Vinyl Pyrrolidone) (PVP) and annealing on the structural and magnetic properties of Zinc ferrite nanoparticles (ZFNPs) synthesis were investigated in this work. The effects were evaluated using the X-ray diffraction (XRD) spectroscopy, Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and Vi-brating sample magnetometer (VSM). The XRD analysis confirms a good formation of the inverse spinel crystal structure with an average particle size of 1.3 nm to 15.2 nm and from 1.6 nm to 21.1 nm for the ZFNPs as-prepared and PVP mediated ZFNPs for the un-annealed and annealed samples, respectively. The SEM image reveals an increase in the particle size for both the as-prepared and PVP mediated samples after annealing at 500°C. The FTIR also reveals the inverse spinel structure for the as-prepared and annealed samples, which witnesses a vibrational red shift towards a higher wave number for the annealed samples. The VSM analysis indicates the superparamagnetic behavior of PVP mediated and annealed sample with zero remanence magnetization (Mr) and Coercivity (Hc). The saturation magnetization (Ms) increases from 1.31 emu/g, for the as-prepared samples, to 4.31 emu/g after the annealing and from 1.18 emu/g, for the PVP mediated, to 6.38 emu/g after annealing. These effects have been attributed to the cationic re-arrangement on the lattice site after the annealing. This presents a superior material for various applications in nanotechnology.
Clinical practice development

The five papers presented here all have a common focus on ‘practice development/ developing practice’ and I welcome the fact that the Journal of Research in Nursing has chosen to focus on this topic and the opportunity to comment on the papers. In the past I have been accused of making practice development my own personal ‘cottage industry’ (Walker, 2009) and so it is a delight to see that industry become a ‘corporate’! At a time in global healthcare when practice development activity is under greatest threat, due to economic downturns that have impacted on health and social care services, the timing of these papers is significant in bringing practice development into the vistas of health and social care reform. Thinking about this commentary and having read the papers made me reflect on the life course of practice development, from its early inception in the UK in the 1980s to where it is now as an increasingly accepted global movement. The journey through this period has been turbulent and researchers such as me (and others) who have taken an active interest in practice development are labelled as the charlatans of the research world (see editorials by Walker (2009) and Thompson et al. (2008), for example). Despite such critique, practice development in its various guises (and disguises) has persisted through major health and social care reform, through professional nursing role development and through an interdisciplinary practice agenda that has at times appeared to be more about boundary management than service effectiveness. Through all of these changes, practice development has adopted and adapted in order to retain its central focus, that of the development of increased effectiveness in person-centred practice through the changing of workplace cultures (Manley et al., 2008). Methodologies have become more sophisticated in the way that models for enabling collaborative, inclusive and participative approaches to working with everyday nurses (and other team members) have become integrated and fine tuned. Evaluation frameworks are more sophisticated and approaches such as ‘Praxis Evaluation’ (Wilson et al., 2008) have been derived from systematic analysis and scholarly inquiry into practice development activity. So, in summary there is much to be celebrated about the achievements of practice development and its contribution to contemporary nursing and patient care, as evidenced in the first systematic review of practice development conducted by McCormack et al. (2006).
Research of in-phase supermode in 16-core Ho3+-doped fluorotellurite photonic crystal fiber lasers

16-core photonic crystal fiber (PCF) was designed. In order to obtain spatially flat in-phase modes, the super-mode near- field properties were studied through method of numerical simulation calculation and according to coupled mode theory. On the based of the scalar Fraunhofer Diffraction, a far- field in-phase super-mode theoretical modeling was presented. According to the modeling, one discussed the influence of the random phase perturbation, the random amplitude perturbation and the polarization direction perturbation on the far-filed intensity distribution, in detail. The results show that both phase perturbation and amplitude perturbation sharply impact the far-filed distribution of interference intensity and contrast. However, the influence of the polarization direction perturbation is not obvious. When the parameterδ, μ and ▵ increases, the field center intensity decreases and the power of the central spot also does, which means the profile of the spot will blur and the beam quality drop.
Risk of Congenital Heart Disease in Newborns with Prenatal Exposure to Anti-depressant Medications

Introduction It is uncertain whether the use of selective serotonin-reuptake inhibitors (SSRI) and other anti-depressants during pregnancy is associated with an increased risk of congenital heart disease (CHD) in newborn. There have been various studies showing a number of adverse outcomes, including gestational hypertension, reduced birth weight, altered neonatal pain responses and persistent pulmonary hypertension of the newborn with exposure to anti-depressant medications. There have been very few longitudinal studies showing CHD association with the use of anti-depressant medications. Our objective is to examine the risk for congenital heart disease of the newborn associated with prenatal exposure to antidepressant medication. Methods We reviewed charts of mothers who were referred for a fetal echocardiogram between January 1st, 2009 and December 31st, 2014. We identified mothers who were exposed to antidepressant medications prenatally. Fetal echocardiograms for these patients were reviewed by two fetal cardiologists and each was blinded to the others' findings. Results A total of 40 patients were identified with prenatal exposure to SSRI. Seven (18%) out of these 40 were found to have a form of CHD. Two fetuses whose mothers were exposed to fluoxetine during pregnancy had large posteriorly malaligned ventricular septal defect, sub-aortic stenosis and critical coarctation identified on fetal echocardiogram. Exposure to citalopram during pregnancy was found to be associated with a moderate size secundum atrial septal defect on one patient and a moderate size mid muscular ventricular septal defect seen on fetal echocardiogram in another patient. Exposure to venlafaxine during pregnancy showed two small muscular ventricular septal defects on fetal echocardiogram on one patient and ductal constriction with increased ductal velocity on another patient. One of the women on escitalopram had a fetus with a large membranous ventricular septal defect (VSD), secundum atrial septal defect (ASD) and left superior vena cava. None of the women on a combination of drugs had CHD. Conclusion There is a risk of congenital heart disease in patients who are prenatally exposed to anti-depressant medications as evident by the specific echocardiographic abnormalities noted in the study.