Miracle-dz/UniFAR-FTUs huggingface dataset:
Simulation of Systolic Arrays on the Connection Machine

The use of a programming model which extends naturally from the underlying hardware, greatly eases the design and implementation of simulators, especially for those systems that resemble the hardware in the paradigm of computation. Given the characteristics of systolic arrays, SIMD computers which employ the data parallel programming model provide an ideal environment. In this paper, we present a systolic array simulator, a simulation tool written for the Connection Machine *(model CM2), a SIMD machine with pomerful interprocessor communication capabilities. Especially as recent advances have automated the design, there is a need for a verification environment to prototype systolic arrays. Primarily a simulation tool, the systolic array simulator also helps identify inefficiencies and motivates optimal design prior to implementation in either custom VLSI or DSP systems. Currently, we are updating the tool to allow the simulation ofdynamic array reconfiguration algorithms under transient and permanent fault conditions. The simulator is also being ported to the CMS.
Medicinal Plants with Antiplatelet Activity

Blood platelets play an essential role in the hemostasis and wound‐healing processes. However, platelet hyperactivity is associated to the development and the complications of several cardiovascular diseases. In this sense, the search for potent and safer antiplatelet agents is of great interest. This article provides an overview of experimental studies performed on medicinal plants with antiplatelet activity available through literature with particular emphasis on the bioactive constituents, the parts used, and the various platelet signaling pathways modulated by medicinal plants. From this review, it was suggested that medicinal plants with antiplatelet activity mainly belong to the family of Asteraceae, Rutaceae, Fabaceae, Lamiaceae, Zygophyllaceae, Rhamnaceae, Liliaceae, and Zingiberaceae. The antiplatelet effect is attributed to the presence of bioactive compounds such as polyphenols, flavonoids, coumarins, terpenoids, and other substances which correct platelet abnormalities by interfering with different platelet signalization pathways including inhibition of the ADP pathway, suppression of TXA2 formation, reduction of intracellular Ca2+ mobilization, and phosphoinositide breakdown, among others. The identification and/or structure modification of the plant constituents and the understanding of their action mechanisms will be helpful in the development of new antiplatelet agents based on medicinal plants which could contribute to the prevention of thromboembolic‐related disorders by inhibiting platelet aggregation. Copyright © 2016 John Wiley & Sons, Ltd.
Preparation strategy and illumination of three-dimensional cell cultures in light sheet–based fluorescence microscopy

Abstract. A device for selective plane illumination microscopy (SPIM) of three-dimensional multicellular spheroids, in culture medium under stationary or microfluidic conditions, is described. Cell spheroids are located in a micro-capillary and a light sheet, for illumination, is generated in an optical setup adapted to a conventional inverse microscope. Layers of the sample, of about 10 μm or less in diameter, are, thus, illuminated selectively and imaged by high resolution fluorescence microscopy. SPIM is operated at low light exposure even if a larger number of layers is imaged and is easily combined with laser scanning microscopy. Chinese hamster ovary cells expressing a membrane-associated green fluorescent protein are used for preliminary tests, and the uptake of the fluorescent marker, acridine orange via a microfluidic system, is visualized to demonstrate its potential in cancer research such as for the detection of cellular responses to anticancer drugs.
Narratives of professional regulation and patient safety: The case of medical devices in anaesthetics

Government prescription for the management of clinical risk and patient safety relies upon the development of a shared perspective between stakeholders engaged in the delivery of healthcare about what constitutes clinical risk and what mechanisms are suitable to manage such risk to ensure patient safety. However, there are tensions arising from notions of clinical risk and its management, specifically between healthcare professionals and those managers given responsibility for implementation of policy. Central to these tensions are issues of legitimacy, power and identity in claims about how risk should be managed. Aligned with an emerging body of literature that takes a narrative approach to change in healthcare systems (e.g. Currie and Brown 2003), including patient safety (e.g. McDonald et al. 2005, 2006), our paper examines how healthcare professionals make sense of the regulation of single use medical devices (SUDs) in anaesthesia. Our study indicates that there is considerable resistance to detailed surveillance of SUDs. It appears that doctors author a narrative that privileges clinical judgement over managerial control in the use of SUDs, and this has come to be adopted by other healthcare professionals and managers. This may undermine future policy aspirations for the tighter regulation of clinical autonomy.
Razões de mortalidade frente ao efeito desigualdade em estudos de mortalidade associada a categorias ocupacionais e níveis sociais

As razoes de mortalidade: "Standardized Risk Ratio" (SRR), "Standardized Mortality Ratio" (SMR) e "Standardized Proportional Mortality Ratio" (SPMR) sao apresentadas visando divulgar uma metodologia para o estudo da mortalidade associada a categorias ocupacionais e niveis sociais. Discute-se a influencia do "Healthy Worker Effect" e do Efeito Desigualdade na escolha da populacao de referencia e apresenta-se uma forma operacional de testar a significância estatistica dessas razoes.
Berberis Vulgaris and Berberine: An Update Review

Berberine is an isoquinoline alkaloid present in several plants, including Coptis sp. and Berberis sp. Berberine is a customary component in Chinese medicine, and is characterized by a diversity of pharmacological effects. An extensive search in electronic databases (PubMed, Scopus, Ovid, Wiley, ProQuest, ISI, and Science Direct) were used to identify the pharmacological and clinical studies on Berberis vulgaris and berberine, during 2008 to 2015, using ‘berberine’ and ‘Berberis vulgaris’ as search words. We found more than 1200 new article studying the properties and clinical uses of berberine and B. vulgaris, for treating tumor, diabetes, cardiovascular disease, hyperlipidemia, inflammation, bacterial and viral infections, cerebral ischemia trauma, mental disease, Alzheimer disease, osteoporosis, and so on. In this article, we have updated the pharmacological effects of B. vulgaris and its active constituent, berberine. Copyright © 2016 John Wiley & Sons, Ltd.
Correction to “Modeling and Analysis of Small Cells Based on Clustered Stochastic Geometry”

In the title letter, Y. Wang et al. analyzed the downlink coverage of small cells, deriving an erroneous new formula Lemma 1. Adducing apropos delineations, this letter, first of all, points out the flaw in the proof of the Lemma 1, and then, emends the two theorems, Theorem 1 and Theorem 2, which stand for the downlink coverage analysis.
The Making and Breaking of Affectional Bonds

Consisting of seven lectures that John Bowlby gave between 1956 and 1977, this book introduces and explores subjects that are still at the forefront of child and adolescent psychiatry today. It is impossible to overestimate Bowlby’s influence on subsequent psychiatric research and practice. The acknowledged “father of attachment theory,” he focused on child development, though his interests were far wider. A clear thinker with a dislike of jargon, he could quote Oscar Wilde (“Each man kills the thing he loves”), Shakespeare (“Give sorrow words”), or (rather alarmingly) George Bernard Shaw (“Never hit a child except in hot blood”). Bowlby had …
Transformative Metropolitan Development Models in Large Canadian Urban Areas: The Predominance of Nodes

The paper centres on the content of metropolitan-scale plans of the six largest Canadian urban regions. Plans in all these regions promote intensification and alternatives to automobile use, and thus adhere to smart growth and sustainability principles. In all cases save one, reliance on nodal development is the preferred manner of achieving intensification and ensuring its co-ordination with public transit services. Meanwhile, however, results point to differences in the stage of development of metropolitan planning strategies. The paper concludes by reflecting on the wide adoption of the nodal model in metropolitan plans. It interprets this popularity as the outcome of the ability of nodes to achieve intensification and reduced car reliance objectives, while conforming to prevailing planning and institutional capacity. The effectiveness of the nodal approach and other broad metropolitan planning concepts rests in their capacity to procure a metropolitan structure for the other scales at which urban planning is practised.
Developing High-Functioning Teams: Factors Associated With Operating as a “Real Team” and Implications for Patient-Centered Medical Home Development

Team-based care is a foundation of health care redesign models like the patient-centered medical home (PCMH). Yet few practices rigorously examine how the implementation of PCMH relates to teamwork. We identified factors associated with the perception of a practice operating as a real team. An online workforce survey was conducted with all staff of 12 primary care sites of Cambridge Health Alliance at different stages of PCMH transformation. Bivariate and multivariate analyses of factors associated with teamwork perceptions were conducted. In multivariate models, having effective leadership was the main factor associated with practice teamwork perceptions (odds ratio [OR], 10.49; 95% confidence interval [CI], 5.39-20.43); in addition, practicing at a site in an intermediate stage of PCMH transformation was also associated with enhanced team perceptions (OR, 2.44; 95% CI, 1.28-4.64). In a model excluding effective leadership, respondents at sites in an intermediate stage of PCMH transformation (OR, 1.95; 95% CI, 1.1-3.4) and who had higher care team behaviors (such as huddles and weekly meetings; OR, 3.41; 95% CI, 1.30-8.92), higher care team perceptions (OR, 2.65; 95% CI, 1.15-6.11), and higher job satisfaction (OR, 2.00; 95% CI, 1.02-3.92) had higher practice teamwork perceptions. This study highlights the strong association between effective leadership, care team behaviors and perceptions, and job satisfaction with perceptions that practices operate as real teams. Although we cannot infer causality with these cross-sectional data, this study raises the possibility that providing attention to these factors may be important in augmenting practice teamwork perceptions.
Message Formats, Numeracy, Risk Perceptions of Alcohol-Attributable Cancer, and Intentions for Binge Drinking Among College Students

We conducted an experiment to examine whether risk perceptions of alcohol-attributable cancer influence college students’ binge-drinking intention and to explore how message formats (text, table, and graph) and numeracy influence risk perceptions of alcohol-attributable cancer. We found that a majority of participants (87%) perceive some risks of alcohol-attributable cancer. Risk messages in tabular and graphic formats are more effective in elevating risk perceptions, but there is no significant difference between these two formats. Numeracy and its interaction with message formats, however, do not predict risk perceptions. We recommend risk messages should be delivered using tabular or graphic formats to enhance risk perceptions. We also advocate the less-is-more principle in presenting risk information.
Attitudes and Practices Regarding Responsible Beverage Service: Focus Group Discussions With Bar and Restaurant Management and Staff

Staff and management of bars and restaurants are the key players in assuring responsible beverage service (RBS) and preventing the overservice of alcohol to intoxicated patrons. We conducted six focus group discussions (N = 42) with management and staff from bars and restaurants about RBS. We compared findings from these current discussions to results of focus group discussions conducted in the 1990s. In comparison to the earlier focus group discussions, we found that many managers and staff members had experience with RBS training programs, establishments generally had written alcohol service policies, and managers and staff members perceived greater likelihood of facing consequences from law enforcement for serving underage youth. Managers and servers also expressed greater concern about overservice of alcohol but did not report greater concern about potential legal consequences for overservice of alcohol than participants from the 1990s focus groups. Results of this study can inform training and enforcement approaches to addressing overservice of alcohol.
Vision 2020 – the Right to Sight

The available data suggests that there were approximately 50 million blind people in the world in the year 2000. The majority live in Asia and Africa. Each year about 8 million people become blind and it is estimated that around 6 million people who are blind die each year. The result is a net increase of 1-2 million blind people per year partly due to an increasing and ageing population. Approximately 50% of all blindness is due to cataract, 15% due to trachoma, up to 10% due to uncorrected refractive errors, 4% due to blindness in children and 1% -due to onchocerciasis. These five conditions cause up to 80% of the world's blindness. The remaining 20% is caused by a variety of causes including glaucoma and diabetic retinopathy (Table I). Blindness is an increasing problem causing loss of quality oflife to the individual and is an economic burden to the individual, the family and to society in general.
Intravascular optical coherence tomography to characterize tissue deformation during angioplasty: preliminary experiments with artery phantoms

Abstract. We explored the potential of intravascular optical coherence tomography (IVOCT) to assess deformation during angioplasty balloon inflation. Using a semi-compliant balloon and artery phantoms, we considered two experimental scenarios. The goal for the first scenario was to investigate if variation in the elasticity of the structure surrounding the balloon could be sensed by IVOCT monitoring. In this scenario, we used three single-layer phantoms with various mechanical properties. Image analysis was performed to extract the inner and outer diameters of the phantoms at various pressures. The goal for the second scenario was twofold. First, we investigated the IVOCT capability to monitor a more complex balloon inflation process. The balloon was in a folded state prior to inflation. This allowed studying two stages of deformation: during balloon unfolding and during balloon expansion. Second, we investigated IVOCT capability to monitor the deformation in a three-layer phantom used to better mimic a true artery. So, not only were the IVOCT images processed to provide the inner and outer diameters of the phantom, but the layer thicknesses were also determined. In both scenarios, IVOCT monitoring revealed to be very efficient in providing relevant information about the phantom deformation during balloon inflation.
Autonomy and confidentiality: patients’ perspectives

Background Little is known about patients’ opinions about their rights in autonomy and confidentiality concerning their illness and this study was conducted to assess it. Methods This multi-centred, cross-sectional study was conducted in outpatient clinics in Khartoum, Sudan. It was delivered to 295 respondents. Data were managed using Microsoft Excel 2010 and SPSS. Results Eighty-five percent of the patients wanted to know about their conditions, of whom 17% wanted to choose their treatment and 29% believed they had the right to refuse treatment. Most of the respondents would not wish to hide information from their doctors. There was a wide variation at the rate of patients hiding information from their relatives, depending on their diagnosis (HIV 90%, malignancy 16.7% and tuberculosis 0%.) Conclusion Respondents want to choose their treating doctor, know about their diseases, be consulted before a procedure. They would like to leave technical issues to their treating doctors without jeopardising their own rights.
Simulation of the Ku-band Radar altimeter sea ice effective scattering surface

A radiative transfer model is used to simulate the sea ice radar altimeter effective scattering surface variability as a function of snow depth and density. Under dry snow conditions without layering these are the primary snow parameters affecting the scattering surface variability. The model is initialized with in situ data collected during the May 2004 GreenIce ice camp in the Lincoln Sea (73/spl deg/W; 85/spl deg/N). Our results show that the snow cover is important for the effective scattering surface depth in sea ice and thus for the range measurement, ice freeboard, and ice thickness estimation.
RELATION OF FIELD CONTRACTION TO BLOOD PRESSURE IN CHRONIC PRIMARY GLAUCOMA

It is common experience that in cases of chronic primary glaucoma there is often an inconsistency between the height of the intraocular pressure and the rate of contraction of the visual fields. There are those cases in which the intraccular pressure is slightly above normal, or even normal, and the fields show progressive contraction, and there are those in which the intraocular pressure is well elevated and the fields show little or no tendency toward progressive contraction. Certainly the elevated intraocular pressure is the most important factor in the contraction of a field, but there are other factors which tend in some instances to nullify and in other instances to augment its deleterious effects. If these factors could be determined and their relation be better understood, indications for treatment would be clearer and the prognosis more accurate. If it is assumed that the field changes in glaucoma have a vascular
Continental-Scale Evaluation of Remotely Sensed Soil Moisture Products

A new data assimilation-based approach for the continental-scale evaluation of remotely sensed surface soil moisture retrievals is applied to four separate soil moisture products over the contiguous U.S. The approach is based on quantifying the ability of a given soil moisture product to correct for known rainfall errors when sequentially assimilated into a simple water balance model. Analysis results provide new insight into the continental-scale performance of surface soil moisture retrieval algorithms based on satellite passive microwave, scatterometer, and thermal remote sensing observations.
Anorexia nervosa in pregnancy

Anorexia nervosa is a psychiatric disorder which is most common in young women and which has the highest mortality rate among all psychiatric disorders. In pregnant women with anorexia nervosa a six‐fold increase in perinatal mortality rate has been reported. There is a lack of evidence‐based obstetric guidelines for the management of pregnant women with anorexia nervosa. This article looks into the effects of anoxexia nervosa on pregnancy and vice versa, and suggests a streamlined management plan.
The still point of the turning world? Building on Balint

In this article, I will respond to the conference title “Building on Balint” by briefly considering some of the inherent obstacles to Balint work, before describing the current state of play in the UK. I will argue that Balint work might benefit from exploring its relationship with attachment theory more fully. In particular, I emphasize an important new role for Balint groups within contemporary health-care organizations—one that enhances a feeling of emotional security for the professional within the organization and also benefits the teamwork and morale of the organization itself. I will give an example of a Balint group in a health-care organization for vulnerable doctors and finish by giving a report on the development of Balint groups for medical students in the UK.
Virtual-address caches. Part 1: problems and solutions in uniprocessors

This survey exposes the problems related to virtual caches in the context of uniprocessor (Part 1) and multiprocessor (Part 2) systems. We review proposed solutions that have been implemented or proposed in different contexts. The idea is to catalog all solutions, past and present, and to identify technology trends and attractive future approaches. We first overview the relevant properties of virtual memory and of physical caches. To solve the virtual-to-physical address bottle-neck, processors may access caches directly with virtual addresses. This survey introduces the problems and discusses solutions in the context of single-processor systems.
Area I/O's potential for future processor systems

Bandwidth, latency, system speed, and, of course, the size of future microprocessor systems all highly depend on interconnection technologies. Interconnection will become the key performance bottleneck as semiconductor technology improvements continue to reduce feature size. In this article, we describe the use of on-chip area I/O for future microprocessor systems on the basis of a case study we made of an Intel Pentium system. Area I/O is simply a method of locating I/Os over the entire chip instead of just the periphery. We show that system designers can achieve significant performance gains with area I/O and size reductions at both the system and chip levels. We also explain how area I/O in conjunction with high-density interconnects leads to a new package and chip partitioning concept.
Ghrelin Agonist (TZP‐101): Safety, Pharmacokinetics and Pharmacodynamic Evaluation in Healthy Volunteers: A Phase I, First‐in‐Human Study

The authors evaluate the human safety, tolerability, pharmacokinetics, and pharmacodynamics of TZP‐101, an agonist of the hGHS‐R1a (ghrelin) receptor. Healthy subjects were randomized to either single‐dose TZP‐101 (20–600 μg/kg) or placebo by 30‐minute intravenous infusion. Subjects underwent continuous cardiac monitoring, 12‐lead electrocardiograms, and assessment for orthostatic hypotension, injection site tolerability, vital signs, and adverse events during the 24‐hour postdose period. Blood and urine samples were collected for pharmacokinetic/pharmacodynamic assessment for 24 hours. Forty‐eight subjects randomly received 1 of 6 TZP‐101 doses or placebo. TZP‐101 was well tolerated, with single episodes each of headache, lower abdominal pain, diarrhea, and dizziness. At the highest dose, 2 subjects experienced bradycardia. All events were self‐limited. Mean arterial blood pressure and heart rate decreased from baseline approximately 45 to 60 minutes after infusion start at higher doses. No other significant changes were observed. Pharmacokinetic analysis revealed less than dose‐proportional behavior of drug with low clearance (≅7 mL/h/kg), small volume of distribution (≅114 mL/kg), and half‐life values of ≅13 hours, which were independent of dose. Pharmacodynamic analyses suggested TZP‐101, at doses as low as 40 μg/kg, expressed activity at the receptor. TZP‐101 displayed a promising pharmacokinetic, pharmacodynamic, and safety profile for use in gastrointestinal motility disorders.