Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhanced Energy Efficient Virtual Machine Placement Policy for Load Balancing in Cloud Environment

Cloud computing is an emerging computing technology that uses the Internet and central remote services to maintain data and application which are provisioned on-demand and on pay-as-you-go basis. Wide adaptation of Cloud concepts has increased number of data centers worldwide resulting into significant amounts of power consumption by datacenters which affects environment and economical aspects. Through virtualization, multiple virtual machines (VM) can be deployed onto one physical machine (PM). These VMs hold and execute the Cloud workload. Efficient allocation of VMs on PM may lead to better resource utilization and result into saving in energy. In this research, we aim to provide enhanced energy efficient VM placement policy for load balancing in Cloud environment which places the VMs in such as way that hosts overload and underload situation is addressed and maintain Service Level Agreement (SLA) between the Cloud provider and the user. In addition, we propose power aware algorithm to reduce energy consumption and achieve better load balancing.
[Diabetic co-morbidities: prevalences in Germany].

In some patients with diabetes mellitus (DM) chronic hyperglycemia leads to microvascular complications in retina, kidney and nerves. Concerning missing data from Germany cited prevalence in German educational books and guidelines arise from other countries. This review demonstrates the prevalence of diabetic comorbidities in Germany. The largest investigation in Germany is the Disease-Management-Programm Nordrhein with more than 450.000 surveyed DM patients. These researches show good comparability with most analyses respective to the prevalence of diabetic comorbidities in Germany. Patients with DM2 have a mean Hba1c of 7 % and patients with DM1 of 7.9 %. In patients with DM2 the prevalence of retinopathy is 11 %, nephropathy 10 % and neuropathy 20 %. Co-morbidities are more commonin patients with long diabetes duration and high HbA1c. In patients with DM1 the prevalence of retinopathy is 25 %, of nephropathy 15 % and neuropathy 27 %. The prevalence of diabetic co-morbidities in primary care in Germany is considerably lower as mentioned in educational books or guidelines. This positive development is reasonable through a better quality of care, nationwide early detection examinations and training programmes.
Prevalence of Human Papillomavirus in Women from the State of Michoacan, Mexico, Showed High Frequency of Unusual Virus Genotypes.

BACKGROUND Human papillomaviruses (HPVs), the leading cause of cervical cancer, are distributed worldwide, with high prevalence in developing countries. OBJECTIVE The objective of the study is to know the prevalence and genotypes of HPV in women from the state of Michoacán and the Women's Hospital in Morelia, Michoacán. MATERIALS AND METHODS Cervical smear samples (159,288) were subjected to HPV detection by hybrid capture 2. A subsample of 484 patients from the Women's Hospital was studied by Papanicolaou test and linear array HPV genotyping, and when positive, patients were also examined by colposcopy and histopathology. RESULTS The overall prevalence for HPV in Michoacán State was 7.74%; 7.11% in 2009, 6.46% in 2010, 9.58% in 2011, and 8.43% in 2012. The highest prevalence was found in the age groups < 25 and 25-34 years. The prevalence at the Women's Hospital was 8.51%. Cytological examination revealed normal cytology in 64.44% of samples, 26.66 % with low-grade and 8.88 % with high-grade squamous intraepithelial lesion (HSIL). However, by colposcopy, normal tissue appearance was found only in 26.66%; 51% were reclassified as low-grade squamous intraepithelial lesion, 17.77% as HSIL, and in 4.4% atrophy was observed. The most prevalent genotype in single infections was HPV59, followed by HPV51 and HPV45. Double infections occurred with the following genotypes: 52-53, 51-59, 61-67, 66-11, 16-62, 53-62, 59-CP6108, 45-66, and 45-51. Triple infections were identified as: 6-31-39, 51-59-62, 51-62-81, 54-55-59, 16-58-71, and 16-59-62. CONCLUSIONS The prevalent genotype found among women from Michoacán, HPV59, was different to the rest of the country. The high prevalence of HPV59 could be due to cases imported to Michoacán by agricultural workers migrating to the USA or may be associated to ethnicity differences. Implications of this finding for immunization programs should be explored.
Prevention of atherosclerosis by specific AT1-receptor blockade with candesartan cilexetil

Several studies indicate that blockade of the renin-angiotensin-aldosterone system (RAAS) can prevent atherosclerosis and vascular events, but the precise mechanisms involved are still unclear. In this study, we investigated the effect of the AT 1-receptor blocker, candesartan, in the prevention of atherosclerosis in Watanabe heritable hyperlipidaemic (WHHL) rabbits and also the effect of AT1-receptor blockade in the uptake of oxidised LDL by macrophage cell cultures. In the first set of experiments, 12 WHHL rabbits were randomly assigned to three groups: placebo, atenolol 5 mg/kg daily or candesartan 2 mg/kg daily for six months. Compared with controls and atenolol-treated rabbits, candesartan treatment resulted in a significant 50—60% reduction of atherosclerotic plaque formation and a 66% reduction in cholesterol accumulation in the thoracic aorta. Studies in macrophage cultures indicated that candesartan prevented uptake of oxidised LDL-(oxLDL)-cholesterol by cultured macrophages. Candesartan inhibited the uptake of oxLDL in a dose-dependent manner, reaching a maximum inhibition of 70% at concentrations of 5.6 µg/ml. Further studies in other animal models and well-designed trials in humans are warranted to further explore the role of AT1-receptor blockade in the prevention of atherosclerosis.
Uma análise dos principais tópicos de pesquisas investigados pelos pesquisadores doutores brasileiros

The production and publication of scientific papers presented an impressive growth in the last decades, being the Internet the main factor of access and diffusion of these to the community. Given this context, there is a global interest in all areas of knowledge regarding studies of scientific production data, in order to know what has been done about science. The understanding of how the researches have evolved may serve as a basis to build scientific policies that accelerate the progress of science or to impel research groups to become more productive. In this context, the aim of this study is to analyze the research topics published during the last 55 years in the Brazilian Science trajectory of researchers with a doctoral degree, in order to map scientific knowledge and identify hot topics. For this, the general characterization and an analysis of data related to the keywords of the articles published in congresses annals and in periodicals are carried out, written by the researchers who have curricula registered in the Lattes Platform. The results showed an overview of the keywords used by the PhDs, and identification and analysis of the main research topics developed by them. Also the validity of the results from the quantitative point of view was verified, to help the understanding about the development of the Brazilian science.
Glucosyltransferases of Viridans Group Streptococci Modulate Interleukin-6 and Adhesion Molecule Expression in Endothelial Cells and Augment Monocytic Cell Adherence

ABSTRACT Recruitment of monocytes plays important roles during vegetation formation and endocardial inflammation in the pathogenesis of infective endocarditis (IE). Bacterial antigens or modulins can activate endothelial cells through the expression of cytokines or adhesion molecules and modulate the recruitment of leukocytes. We hypothesized that glucosyltransferases (GTFs), modulins of viridans group streptococci, may act directly to up-regulate the expression of adhesion molecules and also interleukin-6 (IL-6) to augment monocyte attachment to endothelial cells. Using primary cultured human umbilical vein endothelial cells (HUVECs) as an in vitro model, we demonstrated that GTFs (in the cell-bound or free form) could specifically modulate the expression of IL-6, and also adhesion molecules, in a dose- and time-dependent manner. Results of inhibition assays suggested that enhanced expression of adhesion molecules was dependent on the activation of nuclear factor κB (NF-κB) and extracellular signal-regulated kinase and that p38 mitogen-activated protein kinase pathways also contributed to the release of IL-6. Streptococcus-infected HUVECs or treatment with purified IL-6 plus soluble IL-6 receptor α enhanced the expression of ICAM-1 and the adherence of the monocytic cell line U937. These results suggest that streptococcal GTFs might play an important role in recruiting monocytic cells during inflammation in IE through induction of adhesion molecules and IL-6, a cytokine involved in transition from neutrophil to monocyte recruitment.
La Gestión Universidad-Empresa en la formación del Capital Humano

El estudio tuvo como proposito generar aportes teoricos sobre la formacion del capital humano dentro de la accion compartida Universidad – Empresa, para promover la competitividad y el desarrollo sostenible a traves de una gestion del conocimiento que satisfaga las necesidades reales de la sociedad. El escenario investigado incluye: Decanato de Investigacion, Extension, Postgrado y Pregrado de las universidades y departamentos de adiestramiento de las empresas. Los informantes clave fueron: directores de area y jefes de departamentos. Entre las principales conclusiones se puede senalar: que los programas academicos deben ser pertinentes con la realidad del pais, las necesidades de las empresas, y abocados al desarrollo social, comunitario y ambiental. Por lo que se deben crear espacios que fomenten la creatividad e innovacion para el desarrollo de investigaciones relacionadas con la elaboracion y ejecucion de emprendimientos.
WebAnno: a flexible, web-based annotation tool for CLARIN

Richard Eckart de Castilho1 Chris Biemann2 Iryna Gurevych1,3 Seid Muhie Yimam2 (1) Ubiquitous Knowledge Processing Lab (UKP-TUDA) Dept. of Computer Science, Technische Universität Darmstadt (2) FG Language Technology, Dept. of Computer Science, Technische Universität Darmstadt (3) Ubiquitous Knowledge Processing Lab (UKP-DIPF) German Institute for Educational Research and Educational Information http://www. {lt,ukp}. tu-darmstadt.de
The Importance of Lacrimal Diaphragm and Periosteum Suturation in External Dacryocystorhinostomy

Purpose: To evaluate retrospectively the cosmetic and functional effects on success of lacrimal diaphragm and periosteum suturation after the anastamosis of anterior flaps before skin closure in external dacryocystorhinostomy (ext-DCR). Methods: During ext-DCR, lacrimal diaphragm was separated from periosteum over anterior lacrimal crest before entering lacrimal fossa. At the end of ext-DCR, the separated periosteum and lacrimal diaphragm were sutured in the study group (270 patients) and were left unsutured in the age-matched control group (96 patients). The effects of this approach on postoperative appearance of incision area at the 6-month postoperative controls, and functional success (assessed by fluorescein disappearing test) and anatomical success rates (assessed by lacrimal syringing) at the 12-month postoperative controls were evaluated. Results: The anatomic success rate between the 2 groups were found to be similar (94.8% and 92.7% in the study and control groups, respectively, p = 0.447). Fluorescein disappearing test was detected to be normal in 246 patients (91.1%) and 78 patients (81.2%) in the study and control groups, respectively (p = 0.009). Postoperative skin scar was found to develop significantly greater in the control group (p = 0.001). Significant hypertrophic scar was seen in 3 patients (1.1%) and 8 patients (8.3%) in the study and control groups, respectively. No epicanthal fold or webbing occurred in the study group. Conclusion: The preservation of the lacrimal sac wall's attachments at the end of ext-DCR to the medial canthal tendon, orbicularis oculi muscle, and lacrimal diaphragm allows the lacrimal pump to function more effectively. Ext-DCR with suturation of the periosteum and lacrimal diphragm method may provide an excellent functional and aesthetic outcome in the majority of patients.
Improving channel reciprocity for effective key management systems

We propose a secret key management system for wireless ad-hoc networks, by utilizing the random and reciprocal variations of the wireless channel. We record the variations of the received signal strength and pre-process it before quantizing. The pre-processing of channel measurements improves the channel reciprocity. The quantized preliminary keys are then synchronized and their privacy is amplified to obtain, a final secure key. We validate the proposed method on an testbed and evaluate its performance. We also compare our method to other existing methods to show a significant improvement in the performance of key generation.
Calculus and its applications in scale-free networks

The purpose of this article is to highlight and emphasize the applications of calculus in scale-free networks, which have been found as property of many complex networks. There are many different types of real and manmade complex networks in various domain of life ranging from technological, social, biological, transportation and ecological networks among many others. All these networks have shown many similar structural properties in their formation and functions. This article focuses on the most prevalence type of networks known as Scale-Free Networks (SFN). These types of networks have two basic properties: growth and preferential node attachment. In this paper, we analyze and discuss the importance and usage of calculus in understanding the formation of these type of networks, as these networks continuously change their topology by inclusion of new nodes and links as they evolve. Further, as the calculus is the mathematical study of change therefore the applications of calculus in evolution process of complex networks with fitness model have been explained analytically based on fit-get-rich phenomenon in the complex networks as compared to simple BA1 model which is based, only on the consideration of number of nodes linkages in the networks.
Exploring the experience of residents during the first six months of family medicine residency training

Background The shift from undergraduate to postgraduate education signals a new phase in a doctor’s training. This study explored the resident’s perspective of how the transition from undergraduate to postgraduate (PGME) training is experienced in a Family Medicine program as they first meet the reality of feeling and having the responsibility as a doctor. Methods Qualitative methods explored resident experiences using interpretative inquiry through monthly, individual in-depth interviews with five incoming residents during the first six months of training. Focus groups were also held with residents at various stages of training to gather their reflection about their experience of the first six months. Residents were asked to describe their initial concerns, changes that occurred and the influences they attributed to those changes. Results Residents do not begin a Family Medicine PGME program knowing what it means to be a Family Physician, but learn what it means to fulfill this role. This process involves adjusting to significant shifts in responsibility in the areas of Knowledge, Practice Management, and Relationships as they become more responsible for care outcomes. Conclusion This study illuminated the resident perspective of how the transition is experienced. This will assist medical educators to better understand the early training experiences of residents, how these experiences contribute to consolidating their new professional identity, and how to better align teaching strategies with resident learning needs.
Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice

Reduced antigen expression after DNA vaccination could be a factor that limits its therapeutic effects in antigen-expressing tumor-bearing hosts. To examine whether the presence of an antigen-positive tumor results in the destroy of antigen-expressing cells, pCMV-OVA plasmid expressing ovalbumin (OVA), a model antigen, was intradermaly injected to tumor-free mice and those bearing an EG7-OVA tumor, which stably expresses OVA. For a quantitative evaluation of the elimination of antigen-expressing cells, a plasmid independently expressing firefly luciferase and OVA (pCMV-Luc/OVA) was injected to mice that had been untreated or administered with pCMV-OVA, and luciferase activity was measured one week after the administration. In both tumor-free and tumor-bearing mice, a pre-injection of pCMV-OVA reduced the luciferase expression from pCMV-OVA/Luc compared with a pre-injection of an empty plasmid, suggesting that an immune response to antigen-expressing cells is induced. In tumor-bearing mice, OVA-specific humoral and cellular immune responses were detected even before the vaccination, but such responses had no significant effects on the luciferase expression from pCMV-OVA/Luc. These results indicate that DNA vaccination can induce antigen-specific immune response even in tumor-bearing mice, although it is not strong enough to reject the tumor burden.
Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates

We have reported a correlation between hypothalamic expression of Creb-binding protein (Cbp) and lifespan, and that inhibition of Cbp prevents protective effects of dietary restriction during aging, suggesting that hypothalamic Cbp plays a role in responses to nutritional status and energy balance. Recent GWAS and network analyses have also implicated Cbp as the most connected gene in protein-protein interactions in human Type 2 diabetes. The present studies address mechanisms mediating the role of Cbp in diabetes by inhibiting hypothalamic Cbp using a Cre-lox strategy. Inhibition of hypothalamic Cbp results in profound obesity and impaired glucose homeostasis, increased food intake, and decreased body temperature. In addition, these changes are accompanied by molecular evidence in the hypothalamus for impaired leptin and insulin signaling, a shift from glucose to lipid metabolism, and decreased Pomc mRNA, with no effect on locomotion. Further assessment of the significance of the metabolic switch demonstrated that enhanced expression of hypothalamic Cpt1a, which promotes lipid metabolism, similarly resulted in increased body weight and reduced Pomc mRNA.
RELAÇÃO DE GÊNERO NA LIDERANÇA ORGANIZACIONAL – UM ESTUDO DE CASO NA EMPRESA CELULOSE IRANI S/A

Nas ultimas duas decadas, as diferencas de genero em estilos de lideranca tem sido os temas mais intensamente estudados no campo da lideranca. Embora as mulheres tenham aumentado a sua forca de trabalho, elas ainda nao possuem uma parcela significativa nos principais cargos executivos. A pesquisa objetivou analisar a situacao atual de genero nos cargos de lideranca na empresa Celulose Irani S.A. Os dados foram extraidos dos relatorios disponibilizados pela empresa, atualizado em fevereiro de 2017. Para demonstrar o cenario de lideranca na empresa estudada, os cargos foram classificados em tres niveis hierarquicos e comparados com o Relatorio Perfil Social, Racial e de Genero das 500 maiores empresas do Brasil, do Instituto Ethos e Banco Interamericano de Desenvolvimento do Instituto Ethos, base 2015. O resultado apontou uma representacao de 5,7% de mulheres nos cargos de liderancas, considerando a populacao feminina da Celulose Irani, e 1% em relacao a empresa como um todo. Quando segregado nos niveis hierarquicos, resultou em baixa representatividade nos niveis superiores. Ao comparar com outras empresas representadas no relatorio do Instituto Ethos, a representatividade e menor na empresa estudada. Alem disso, a maioria das mulheres se encontra posicionada em cargos de lideranca de primeiro nivel, sendo sua representatividade cinco vezes menor que dos homens. Nos cargos de gerencia, a representatividade e ainda menor. Essa diferenca pode estar relacionada ao segmento que a empresa esta inserida e a falta de oportunidade para assumir cargos de liderancas mais elevados.
How Important Is the Spectral Ripening Effect in Stratiform Boundary Layer Clouds? Studies Using Simple Trajectory Analysis

Abstract Any population of cloud droplets forming on polydisperse condensation nuclei is thermodynamically unstable. There is no value of the supersaturation for which the growth rate of all the droplets is zero, so that if some droplets are in equilibrium, then some must have positive and some negative growth rates. Droplets with positive growth rates will continue to grow at the expense of those with negative growth rates. This effect has been termed the ripening process, and has been postulated to be a potential mechanism to explain broad droplet size distributions in stratiform clouds. In this paper multiple parcel trajectories are used, derived using a simple representation of the turbulent dynamics, to examine the time evolution of the droplet size distribution in a nonentraining stratiform cloud. It is shown that the magnitude of the effect is critically dependent upon the mean parcel in-cloud residence time. The simulations suggest that, for a stratiform clouds of h = 400 m thickness, and a vertic.
Association Between Cholesterol Plasma Levels and Craving Among Heroin Users

Objective:Lipids may play some roles in the central nervous system functions that are associated with drug addiction. To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving. Method:The serum lipid levels of 70 heroin users who were undergoing or had undergone a methadone maintenance therapy were measured. Their craving and demographic data were assessed. Results:Total cholesterol and low-density lipoprotein cholesterol are negatively associated with craving before (r = −0.33, P < 0.01, and r = −0.36, P < 0.01, respectively) and after controlling for the effects of potential confounders (&bgr; = −0.38, P < 0.01, and &bgr; = −0.42, P < 0.01, respectively). Conclusions:Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.
Demand for Seasonal Wage Labour in Agriculture: What Does Family Farming Hide?

type="main" xml:id="jage12019-abs-0001"> This article draws on the agricultural household literature to understand the dynamics of wage labour on farms in a context of family farming. The recent evolution towards an increased use of seasonal wage labour motivates the original distinction of three types of labour: family labour, permanent-wage labour and seasonal-wage labour. Considering the two wage labour types and hiring cost for seasonal workers, our empirical results based on 2000 French data on fruit and vegetable farms suggest that the choice between hiring permanent or seasonal wage labour is not only determined by the seasonality of the activity. Indeed, the characteristics of the local labour market also affect the trade-off between permanent and seasonal wage labour. This result provides insights on the substitutability of the two labour types, especially when the local labour market is tight. Moreover, the substitution of seasonal-wage labour for permanent-wage labour can occur in the agricultural sector as a mean of increasing flexibility as well as reducing costs and commitments. Finally, family labour is found to substitute for wage labour and more specifically for seasonal-wage labour.