Miracle-dz/UniFAR-FTUs huggingface dataset:
The written text in the Athenian political culture in the first decades of 4th century BC

The growing impact of textuality in the classical Greece seems to be generally accepted view. However, the importance of the written text as an autonomous mean of transmission in different spheres of life in Athens in the IV century BC is more complex phenomenon. The purpose of this paper is to present a general sketch of this issue with particular emphasis on politics and individuals whose ambition was to have a real impact on the current affairs. In this context the activity of Isocrates and his self-consciousness provides especially interesting material for debate.
Intelligent Control of Repair Process of Industrial Facilities with Distributed Infrastructure on the Basis of CPS

: The paper presents a brief description of engineering and scientific problems which arise at the steel plant PJSC “ArcelorMittal Kryvyi Rih” when organizing a repair workshop to fix industrial equipment. The attention is paid to innovative methods of repair process based on intelligent agents and Industry 4.0 principles.
Metastatic Model of Colon Carcinoma in Mice: Utility in the Study of Tumor Growth and Progression

Colorectal cancer is the second leading cause of cancer deaths in the United States with an estimated 150,000 diagnosed cases and over 56,000 fatalities annually (Jemal et al., 2006). Approximately one‐third to one‐half of cases are localized to the colon and rectum and have a favorable prognosis, while one‐third to one‐half present with regional lymph node metastases at diagnosis and generally are refractory to various chemotherapeutic regimens. Treatment options (surgery, radiation, and chemotherapy) are limited and the disease carries a grave prognosis for many patients. An orthotopic model of colon carcinoma in mice provides a way to evaluate the pathogenesis of tumor growth and metastasis as an aid in developing effective therapies and to better understand the underlying biology of colon tumor growth and metastasis. The protocol described in this unit details the development and characterization of an orthotopic model of murine colon carcinoma in BALB/c mice with diffuse lymphatic and hepatic metastatic spread, closely mimicking the course of the human disease. Curr. Protoc. Pharmacol. 38:14.5. 1‐14.5. 13. © 2007 by John Wiley & Sons, Inc.
Long-Wavelength Quantum-Dot Infrared Photodetectors With Operating Temperature Over 200 K

We demonstrate the high-temperature operation of confinement enhanced dots-in-a-well (CE-DWELL) quantum-dot infrared photodetectors (QDIPs). The thin Al0.3Ga0. 7As barrier layer added above the InAs QDs greatly improve the lateral confinement of QD states in the In0.15Ga0. 85As DWELL structure and the device performance. With better device parameters of CE-DWELL, it is possible to achieve high quantum efficiency, high operating temperature, and long-wavelength detection at the same time.
Editorial: Hidden Costs and Invisible Contributions in Family Caregiving: An Introduction

Caregiving defies encapsulation. Few subjects have inspired such consistent interest in the gerontological, disabilities, and health care communities. This journal and others in these fields, as well as association newsletters and even the popular press, have focused on the dimensions of caregiving. What is caregiving? The contributors to this issue examine this simple but profound question, revealing the complexity of the ascribed meanings and imbedded values that illuminate and inform this continuing inquiry. Some contributors examine caregiving within families, some the relationships between families and outside agencies such as government, and some the relationships among providers who are outside the family.
Functionality Risk in Information Systems Development: An Empirical Investigation

Functionality risk is defined as the risk that a completed system will not meet its users' needs. Understanding functionality risk is central to successful information systems development (ISD), yet much of the research in this area has focused on identification of risk factors and development of conceptual frameworks. Little is known about how various functionality risk factors collectively influence managers' perceptions about the risk that a project will fail. As organizations become increasingly reliant on software, it is evermore important to understand functionality risk in ISD. In this paper , we develop an integrative model of functionality risk to explain the relative importance of six salient functionality risk factors that have been consistently identified in the prior ISD literature as being important: 1) related technical knowledge; 2) customer involvement; 3) requirements volatility; 4) development methodology fit; 5) formal project management practices; 6) project complexity. The model is tested empirically with 60 highly experienced MIS Directors in sixty organizations. In addition to providing empirical support for the proposed model, the relative importance of each of the key functionality risk factors is empirically assessed. Development methodology fit, customer involvement, and use of formal project management practices emerged as the top three functionality risk factors. Additional finer-grained analyses show that high methodology fit lowers several other sources of risk. Implications for research and practice are discussed
Chalcogenide As2S3 Sidewall Bragg Gratings Integrated on LiNbO3 Substrate

This paper introduces the design and applications of integrated As2S3 sidewall Bragg gratings on LiNbO3 substrate. The grating reflectance and bandwidth are analyzed with coupled-mode theory. Coupling coefficients are computed by taking overlap integration. Numerical results for uniform gratings, phase-shifted gratings and grating cavities as well as electro-optic tunable gratings are presented. These integrated As2S3 sidewall gratings on LiNbO3 substrate provide an approach to the design of a wide range of integrated optical devices including switches, laser cavities, modulators, sensors and tunable filters.
Serodiagnosis Efficacy and Immunogenicity of the Fusion Protein of Mycobacterium tuberculosis Composed of the 10-Kilodalton Culture Filtrate Protein, ESAT-6, and the Extracellular Domain Fragment of PPE68

ABSTRACT In order to identify immunodominant antigens of Mycobacterium tuberculosis that may be used in the serodiagnosis of active tuberculosis (TB), we designed an M. tuberculosis fusion protein consisting of CFP-10 (10-kDa culture filtrate protein), ESAT-6 (6-kDa early secreted antigenic target), and the extracellular domain fragment of PPE68 (PPE68′). Then, the coding sequences of the three proteins were inserted into a prokaryotic expression vector, pET-32a(+). To enhance the immunological response, the proteins were linked together. The fusion proteins with a 6×His tag were successfully overexpressed in Escherichia coli BL21 and purified. The purified proteins were applied for detection of the total IgG titer by using an enzyme-linked immunosorbent assay (ELISA) with human sera from well-characterized TB cases and the control cases, and results were compared to those with purified protein derivative tuberculin (PPD). The ELISA results showed that among 140 cases of confirmed active TB and 70 control cases, CFP-10–ESAT-6–PPE68′ had a sensitivity of 73.3% and specificity of 94.3%, compared to a sensitivity of 66.7% and specificity of 74.3% for PPD and a sensitivity of 65% and specificity of 91.4% for CFP-10–ESAT-6. In addition, the fusion protein CFP-10–ESAT-6–PPE68′ stimulated a higher level of antigen-specific gamma interferon (IFN-γ) release for active-TB patients than PPD and CFP-10–ESAT-6. After immunization of C57BL/6 mice, the findings indicated that the total IgG titers and the concentrations of IFN-γ in mice immunized by CFP-10–ESAT-6–PPE68′ were high and induced strong, long-term humoral immunity compared to results with PPD and CFP-10–ESAT-6. Thus, our study indicates that the fusion protein CFP-10–ESAT-6–PPE68′ may be useful as an immunodominant antigen for the serodiagnosis of active TB.
Probabilistic tracking control for non-Gaussian stochastic process using novel iterative learning algorithms

A new generalised iterative learning algorithm is presented for complex dynamic non-Gaussian stochastic processes. After designed neural networks are used to approximate the output probability density function (PDF) of the stochastic system in the repetitive processes or the batch processes, the complex probabilistic tracking control to the output PDF is simplified into a parameter tuning problem between two adjacent repetitive processes. Under this framework, this article studies a novel model free iterative learning control problem and proposes a convex optimisation algorithm based on a set of designed linear matrix inequalities and L 1 optimisation index. It is noted that such an algorithm can improve the tracking performance and robustness for the closed-loop PDF control. A simulated example is given, which effectively demonstrates the use of the proposed control algorithm.
Teaching health centers and the primary care workforce crisis for the underserved.

TO THE EDITOR: One of the proposed models for national health care is to expand into the natural adjacency of the Medicare and Medicaid systems. However, the influx of new patients will cause an even greater burden on a failing system, and the current workforce of physicians and nonphysician providers will be unable to properly care for these patients. The model proposed by Rieselbach and colleagues (1) seems viable and operationally sound, but the funding mechanism remains a challenge. A plausible funding mechanism would be to allocate a portion of recoveries from the Recovery Audit Contractor (RAC) program to this primary care initiative. Although it is operationally impractical to prevent all improper payments, a January 2008 report by the Office of Management and Budget (2) indicated that Medicare is among the top 3 federal programs with improper payments (not fraud), with an estimated total of $10.8 billion in 2007 (2). The Centers for Medicare & Medicaid Services performed a 3-year pilot RAC program in 3 states. The RACs corrected more than $1.03 billion in improper Medicare payments (2). Conservative estimates suggest that the recoveries from the mature program will exceed $35 billion per year. The Medicare program currently uses payment bonuses to encourage care based on high-quality evidence (3). Increasing qualitybased bonuses to recruit primary care physicians and to diminish the variance between cognitive and procedural physicians makes good sense. In addition, the bonus payments will negate the reimbursement issues associated with rural and community health care. Many community health centers (CHCs) do not have adequate facilities to attract physicians, much less patients. The RAC recoveries could augment funds already designated for electronic health records, state-of-the-art diagnostic tools, and high-quality multimedia educational facilities that would be a “health care destination. ” This prestige is cherished by patients and physicians alike. The model proposed by Rieselbach and colleagues solves 2 major health care problems: the diminishing pool of primary care physicians and the rapidly expanding patient population, which could dramatically increase if national health care requires the expansion of Medicare and Medicaid. Access to high-quality health care in a sustainable system remains a very high priority. I propose a novel funding mechanism that uses money recouped from overpayments to Medicare providers. Expansion of the RAC program into Medicaid and Medicare Parts C and D would provide even greater recoupments. All U.S. residents deserve the highest-quality health care available, and this is one way to provide it.
Oral rehydration therapy — a review

REHYDRATION AND maintenance of adequate fluid and electrolyte balance is the key to the management of the child with acute diarrheal disease. Oral rehydration treatment has been shown to be simple, practical, inexpensive, highly effective and safe for developing as well as for developed countries. A better understanding of the physiological mechanisms implicated in diarrheal illness as well as extensive clinical testing of oral rehydration solutions have lead to the improvement of the composition of electrolyte, carbohydrate and base constituents. The widespread use of oral rehydration therapy may result in a decreased need for hospitalization and less discomfort and complications which are associated with intravenous rehydration therapy.
Modelling and Security Analysis of Authenticated Group Key Agreement Protocols

Authenticated Group Key Agreement Protocols are protocols allowing a group of principals to contributively generate a key by the exchange of messages on a network possibly controlled by an attacker. Furthermore, their execution also guarantees all group members that the key they obtained can only be known by the other intended protocol participants. These protocols can be exploited in many applications such as audio or videoconferencing, replicated servers (such as database, web, time servers), chat or network games for instance. AGKAP's present several particularities that make them interesting case studies for research in the theory of security. At first, the consideration of the number of protocol participants as a parameter raises several complexity problems that are not present in the classical two or three-party frameworks. Furthermore, up to now, the security properties of group protocols have roughly been considered as direct extensions of two-party properties, what does not capture several plausible attack scenarios. A second interesting aspect of the analysis of AGKAP's is the consideration of Diffie-Hellman-type primitives, that present properties out of the scope of most classical models. We started our study with the construction of a simple model for the analysis of a classical family of protocols: the Cliques AGKAP's. This allowed us to discover several attacks and define different flavors of group security properties. We then tried to fix these protocols, what led us to extend our model in order to prove that it is in fact impossible to build a secure AGKAP based on the same design assumptions as the Cliques protocols. Finally, we designed a new AGKAP based on different cryptographic primitives (signature and hash functions) for which we proved authentication, freshness and secrecy properties. A comparison with a similar AGKAP developed in parallel to ours is also proposed.
How groups of people interact with each other on Twitter during academic conferences

This paper shows a work-in-progress of a recently started project, which aims to understand how people interact with each other on Twitter during academic conferences, with emphasis on different user groups. As a first step in that direction, we manually classified the users of four conferences into five user groups and investigated with which other groups they communicate, how much they contribute to the Twitter stream and how much attention they receive from their peers.
Rhabdomyolysis due to lamivudine re-administration in a patient with HBV- related hepatic failure caused by interruption of lamivudine and adefovir

A 47-year-old man with chronic hepatitis B was admitted to Kobe Asahi Hospital on January 26, 2014 presenting with hepatic failure. Laboratory examinations revealed the following: total bilirubin, 3.39mg/dl; aminotransferases, AST, 2,700U/l; ALT, 1,800U/l; prothrombin time 40.8%; HBeAg(+); HBeAb(-) and HBV DNA, 9.1 log IU/ml (Real-time detection PCR test, LSI Medience Corporation, Tokyo). Under the diagnosis of chronic hepatitis B (stage F3), lamivudine (100mg once daily) had been administered since September 2004. Liver function worsened in September 2005, and YIDD mutation was detected. IFN-α 300MU/mg three times a week was administered from October 2005 to August 2006. In September 2006, IFN treatment was replaced by adefovir (10mg once daily). Liver function and virological markers improved steadily from April 2007 to October 2013. Laboratory examinations in June 2013 revealed the following: AST, 28U/l; ALT, 9U/l; HBeAg (-); HBeAb (-); HBV DNA was not detectable. The therapy with lamivudine and adefovir was suspended by the patient in November 2013. On January 26, 2014 when he developed hepatic failure, administration of lamivudine and adefovir was resumed together with entecavir. On February 19, the level of creatine phosphokinase (CPK) was high (4,195 IU/l), and the levels of blood and urine myoglobin reached 648 ng/ml (normal <100 ng/ml) and 570 ng/ml (<8.5 ng/ml), respectively. Troponin T was negative and the isozyme pattern of CPK was type MM. No evidence of muscle trauma, infection, or other metabolic signs were present, and the patient demonstrated no specific symptoms. The drugs administered at the time of increased serum CPK were ursodeoxycholic acid, pitavastatin calcium, lamivudine, adefovir, and entecavir. Under the suspicion of drug-induced rhabdomyolysis, pitavastatin calcium intake was discontinued LETTERS TO THE EDITOR
Subgroup Discovery with Evolutionary Fuzzy Systems in R: The SDEFSR Package

Subgroup discovery is a data mining task half-way between descriptive and predictive data mining. Nowadays it is very relevant for researches due to the fact that the knowledge extracted is simple and interesting. For this task, evolutionary fuzzy systems are well suited algorithms because they can find a good trade-off between multiple objectives in large search spaces. In fact, this paper presents the SDEFSR package, which contains all evolutionary fuzzy systems for subgroup discovery presented throughout the literature. It is a package without dependencies on other software, providing functions with recommended default parameters. In addition, it brings a graphical user interface to avoid the user having to know all the algorithm’s parameters.
A New Correction for Multiple Testing in Gene–Gene Interaction Studies

A major problem in gene–gene interaction studies in large marker panels is how to correct for multiple testing while accounting for the dependence between marker pairs due to the presence of linkage disequilibrium. The “gold standard” approach is to perform permutations of case/control labels. However, this is often not feasible in practice, due to computational demands. Here, we propose a correction based on the effective number of independent tests of interaction between marker pairs. This number depends on the effective number of independent single‐marker tests. We tested its validity using simulated samples, as well as that of another correction of marker pair tests. We showed that our approach was valid while the other correction strongly underestimated the effective number of independent tests. Our method provides estimates of the effective number of independent tests close to those reported in the literature for a Genome‐Wide Interaction Study on a 550K chip. Our correction method is quick and simple, and can be applied whatever the marker panel and the underlying linkage disequilibrium pattern.
Epidemiology of human Schistosoma haematobium infection around Volta Lake, Ghana, 1973-75.

There was a dramatic rise in the prevalence of urinary schistosomiasis around Volta Lake within a year of its full impoundment in 1968. Research was undertaken to investigate the epidemiology of the disease in preparation for a control programme. The interplay of three factors-age, sex, and ethnic affiliation-largely defined the demographic patterns of the prevalence and the intensity of infection. Both of these increased in young children up to a peak at age 10-14 years, and then declined, the intensity of infection more rapidly than the prevalence. The prevalence and intensity of infection were both greater in males than females (above ages 15-24 years and 5-9 years, respectively), and differences between the two main ethnic groups were related to differences in their lake-related activities. Differences between the patterns of prevalence and intensity of infection are attributed to the greater sensitivity of the latter measurement in indicating changes in the level of transmission. Practical difficulties were encountered in obtaining a precise measurement of incidence, the most important being the considerable degree of population movement. A field cohort study showed a seasonality of transmission, greatest between January and April, during the period of high level of the lake and in the early part of the draw-down.Research on the intermediate snail host (Bulinus truncatus rohlfsi) and lakeside ecology established the focality of transmission at human water-contact sites serving the shore-line communities and, in conjunction with parasitological surveys, its seasonality: variations in ecology that accompanied the annual rise and fall of the lake led to high levels of transmission when the water level was high and lower levels during the draw-down.The geographical distribution of the infection was also affected by differences in ecology, specifically by variations in the distribution and abundance of the aquatic weed Ceratophyllum demersum. A non-seasonal decline in transmission observed in one locality during the period from 1973 to 1975 resulted from a local decrease in the amount of Ceratophyllum.
Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers

Background: Recently, a new ablation strategy for atrial fibrillation has emerged, which involves the identification of rotors (ie, local drivers) followed by the localized targeting of their core region by ablation. However, this concept has been subject to debate because the mode of arrhythmia termination remains poorly understood, as dedicated models and research tools are lacking. We took a unique optogenetic approach to induce and locally target a rotor in atrial monolayers. Methods and Results: Neonatal rat atrial cardiomyocyte monolayers expressing a depolarizing light-gated ion channel (Ca2+-translocating channelrhodopsin) were subjected to patterned illumination to induce single, stable, and centralized rotors by optical S1-S2 cross-field stimulation. Next, the core region of these rotors was specifically and precisely targeted by light to induce local conduction blocks of circular or linear shapes. Conduction blocks crossing the core region, but not reaching any unexcitable boundary, did not lead to termination. Instead, electric waves started to propagate along the circumference of block, thereby maintaining reentrant activity, although of lower frequency. If, however, core-spanning lines of block reached at least 1 unexcitable boundary, reentrant activity was consistently terminated by wave collision. Lines of block away from the core region resulted merely in rotor destabilization (ie, drifting). Conclusions: Localized optogenetic targeting of rotors in atrial monolayers could lead to both stabilization and destabilization of reentrant activity. For termination, however, a line of block is required reaching from the core region to at least 1 unexcitable boundary. These findings may improve our understanding of the mechanisms involved in rotor-guided ablation.
Pacific Asia Conference on Information Systems ( PACIS ) 2010 Self-Regulation , Individual Characteristics and Cyberloafing

Cyberloafinga form of counter-productive work behaviour has been found to be affected by several personality and contextual factors. An important relationship that has not been adequately explored in the past is how cyberloafing behaviours could be conceptualized as a failure to self-regulate. In this paper, we examine the impact of this lack self-regulation on cyberloafing. We also examine the effects of individual characteristics (self-efficacy, conscientiousness and achievement orientation) in moderating the relationship between self-regulation and cyberloafing. Results showed that all the individual characteristics are significant moderators. Implications are discussed.