Miracle-dz/UniFAR-FTUs huggingface dataset:
Servant Leadership and Service Performance: A Multilevel Mediation Model

This study proposes and tests a multilevel mediation framework to explicate the processes that link servant leadership to frontline employees’ service performance at both the employee and the branch levels of analysis. Data were obtained from 58 branch managers and 324 branch frontline employees of a chain restaurant in Taiwan. The results of hierarchical linear modelling indicate that two factors, concern climate and work engagement, mediate the relationship between branch managers’ servant leadership and frontline employees’ service performance; and that work engagement mediates the relationship between concern climate and such service performance. The theoretical and practical implications of these findings are considered, along with future research directions and the study’s limitations.
In Vitro Activity of Biometal(II) Complexes of Monensin Against Virus-Induced Transplantable Animal Tumors

ABSTRACT The anticancer properties of monensic acid (MonH) and its complexes with ions of Mg(II), Ca(II), Mn(II) and Co(II) were studied in cultured permanent cell lines originated from virus-induced transplantable tumors in chicken (hepatoma, LSCC-SF-Mc29) and in rat (sarcoma, LSR-SF-SR). The short-term experiments in monolayer adherent cells were performed by thiazolyl blue tetrazolium bromide (MTT) test (hepatoma and sarcoma cell lines) and neutral red (NR) uptake cytotoxicity assay (sarcoma cell line). The effect of monensin and corresponding complexes on the colony-forming ability of tumor cells was also evaluated. From the results obtained it can be concluded that all compounds significantly decrease the viability and proliferation of the treated cells in a time- and concentration-dependent manner, with metal(II) complexes being more effective than the non-coordinated ligand.
Effects of Dandelions on proliferation of spleen Lymphocytes in Mice

Aim To investigate whether dandelions have immunological activities.Methods Immunodificient mice were induced by hydrocortisone,the proliferatory effects on lymphocytes of mice by water extracts of two main dandelions in China,Taraxacum mongolicum and T. sinicum,were investigated.Results Lymphocyte proliferations were apparently antagonized by hydrocortisone and significantly promoted by oral administrations of two water dandelion extracts.There was a marked difference on T lymphocyte proliferations between the therapeutic group and the control group(P0.01),while on B lymphocyte both had a promotion,but there was no significant difference(P0.05). Conclusions Taraxacum herb can protect immunological inhibition by hydrocortisone and have strong immuno-potentiating functions,mainly on T lymphocyte.
Genetic diversity of soil invertebrates corroborates timing estimates for past collapses of the West Antarctic Ice Sheet

Significance Changes in the extent of ice sheets through evolutionary timescales have influenced the connectivity of soil invertebrate populations across the Antarctic landscape. We use genetic divergences to estimate isolation times for soil invertebrates along the Transantarctic Mountains. Four species of Collembola (Arthropoda) each showed genetically distinct populations at locations likely isolated for millions of years. Two further species were less genetically diverse although also range restricted. Our genetic data corroborate climate reconstructions and estimates of past warm periods of reduced ice and absent ice shelf in the Ross Sea region, during which time open seaways would have facilitated dispersal of Collembola, and possibly other taxa. During austral summer field seasons between 1999 and 2018, we sampled at 91 locations throughout southern Victoria Land and along the Transantarctic Mountains for six species of endemic microarthropods (Collembola), covering a latitudinal range from 76.0°S to 87.3°S. We assembled individual mitochondrial cytochrome c oxidase subunit 1 (COI) sequences (n = 866) and found high levels of sequence divergence at both small (<10 km) and large (>600 km) spatial scales for four of the six Collembola species. We applied molecular clock estimates and assessed genetic divergences relative to the timing of past glacial cycles, including collapses of the West Antarctic Ice Sheet (WAIS). We found that genetically distinct lineages within three species have likely been isolated for at least 5.54 My to 3.52 My, while the other three species diverged more recently (<2 My). We suggest that Collembola had greater dispersal opportunities under past warmer climates, via flotation along coastal margins. Similarly increased opportunities for dispersal may occur under contemporary climate warming scenarios, which could influence the genetic structure of extant populations. As Collembola are a living record of past landscape evolution within Antarctica, these findings provide biological evidence to support geological and glaciological estimates of historical WAIS dynamics over the last ca. 5 My.
Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

We examined whether specifically statins, of the major lipid modifiers (statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe) have pleiotropic effects on ischemic heart disease (IHD) via testosterone in men or women. As a validation, we similarly assessed whether a drug that unexpectedly likely increases IHD also operates via testosterone. Using previously published genetic instruments we conducted a sex-specific univariable and multivariable Mendelian randomization study in the UK Biobank, including 179918 men with 25410 IHD cases and 212080 women with 12511 IHD cases. Of these three lipid modifiers, only genetically mimicking the effects of statins in men affected testosterone, which partly mediated effects on IHD. Correspondingly, genetically mimicking effects of anakinra on testosterone and IHD presented a reverse pattern to that for statins. These insights may facilitate the development of new interventions for cardiovascular diseases as well as highlighting the importance of sex-specific explanations, investigations, prevention and treatment.
Use of recombinant activated factor VII for uncontrolled bleeding in a haematology/oncology paediatric ICU cohort

Bleeding among critically ill paediatric haematology/oncology (CIPHO) patients leads to significant morbidity and mortality. Recombinant activated factor VII (rFVIIa) has shown some benefits in previous reported off-label use when conventional therapies have failed. However, data in CIPHO are lacking. We retrospectively studied (2006–2014) the efficacy and outcomes in CIPHO patients younger than 21 years who received at least one rFVIIa dose for bleeding in the ICU. Of 39 patients, the majority had leukaemia (59%), bone marrow transplantation (77%) and a life-threatening bleed (80%) with most common site being pulmonary haemorrhage (44%). Most needed invasive mechanical ventilation (87%) or vasopressor support (59%). After rFVIIa administration, 56% had cessation or decreased bleeding. Packed red blood cell transfusion requirements decreased significantly 48–72 h after rFVIIa administration. Lower baseline prothrombin time and more rFVIIa doses were related to bleeding control. A favourable response was associated with higher survival (55% in responders versus 18% in nonresponders, P = 0.019). Overall, bleeding-related mortality was 37.5%, highest in pulmonary haemorrhage. Two patients had thromboembolic events. Use of rFVIIa for CIPHO patients appears to be well tolerated with low adverse events. Despite half of the patients having a favourable response of cessation or decrease in bleeding after rFVIIa administration, mortality was high. These findings highlight the need for prospective studies to evaluate interventions to improve outcomes in this population.
Redesigned Care Delivery for Insulin-Requiring Diabetes in Pregnancy Improves Perinatal Glycemic Control While Reducing Neonatal Intensive Care Admissions, Length of Stay, and Costs.

Objective: We sought to improve perinatal glycemic control and downstream neonatal outcomes through redesigned ambulatory management for women with insulin-requiring diabetes in pregnancy. Methods: To address gaps in perinatal glycemic management of women with insulin-requiring diabetes in pregnancy, redesigned care delivery (RCD) utilized integrated practice unit and minimally disruptive medicine concepts with incorporation of cellular-enabled glucose monitoring. Primary outcomes of RCD (N = 129) included hemoglobin A1c ([HbA1c], within RCD cohort), and gestational age (GA) at delivery, neonatal intensive care (NICU) admission, and NICU length of stay (LOS) compared with a preredesign care cohort (Pre-RCD; N = 122). Secondary outcomes included facility, payer reimbursement, and program costs. Generalized linear models assessed continuous variables while logistic regression methods assessed categorical outcomes. Results: Utilizing RCD, 92% of women with an initial HbA1c <6.5% maintained glycemic control until delivery, and 67.2% with an initial HbA1c ≥6.5% achieved delivery levels <6.5%. NICU admissions and GA-adjusted LOS decreased significantly [Pre-RCD vs. RCD: NICU admissions, 41.0% vs. 27.3%, p < 0.024; NICU LOS (95% confidence interval [CI]), 21.9 (17.1-26.6) vs. 14.6 (9.1-20.1), p = 0.045]. Every 10 days of redesigned management decreased mean NICU LOS by 1 day. Mean payer neonatal reimbursements decreased over $18,000 per delivery (p = 0.08) compared with implementation costs of $1,942 per delivery. Conclusion: Redesigned perinatal diabetes care with remote glucose monitoring demonstrated improved outcomes and value through downstream neonatal outcomes and lower payer costs. Therefore, subsequent dissemination and sustainability of similar programs' improved outcomes will likely require payer support.
The 6 E Framework of Public Health Preparedness for Mass Gatherings—Lessons Learned From Super Bowl LIII, Fulton County, Georgia, 2019

Supplemental Digital Content is Available in the Text. Context: On February 3, 2019, Atlanta, Georgia, hosted Super Bowl LIII, which is classified as a National Special Security Event. The festivities comprising this major sporting event brought approximately half a million people to Atlanta, which posed significant challenges to the local public health community. As the lead local agency for public health planning, preparedness, and response efforts, Fulton County Board of Health (FCBOH) needed to address multiple specific tasks based on core functional areas outlined in the Emergency Support Function (ESF) 8 (eg, bioterrorism preparedness and epidemiological surveillance). Program: To prepare for the Super Bowl, FCBOH developed a systematic approach to ensure community-wide public health preparedness for mass gatherings. This approach came to be known as the 6 E framework, which consists of (1) engaging stakeholders, (2) examining current capabilities and identifying gaps, (3) establishing roles and responsibilities, (4) executing plans to fill gaps, (5) exercising plans, and (6) evaluating impact. Implementation: We define each step of the 6 E framework and present practical examples of how FCBOH implemented each step when preparing for the Super Bowl. Challenges that FCBOH faced and the lessons learned in the process are illustrated. The 6 E framework provides a systematic approach to community preparedness and allows local health departments to tailor the approach to serve local public health needs. Evaluation: The successful implementation of the 6 E framework allowed for stakeholders at the federal, state, and local levels (including law enforcement) to effectively coordinate an epidemiological investigation and response when 4 staff members reported gastrointestinal symptoms after eating at a feeding station. Discussion: Preparation for the Super Bowl required months of diligent cross-sectoral and cross-jurisdictional partnership building, and the 6 E framework can help other local public health jurisdictions prepare to host major mass gatherings.
Development of Caragana Microphylla Seedling Root System in Hilly Regions of Loess Plateau

The major objective of this study was to characterize the root system of the 1～3 year old seedlings of Caragana microphylla,an important shrub species in Longxi hilly region of the Loess Plateau,China.Root morphology,growth and development,distribution and nodule characteristics were determined after excavation.The results show that the growth rate of the major root of Caragana microphylla was much greater than that of the stem.The ratio of root to shoot ranged from four to six.The lateral roots were found mainly on the 5～15 cm section of the major root.The radicles of Caragana microphylla in average elongated 5 cm upward,implying a reasonable sowing depth of 3 cm.The nodules concentrated mainly on the major root and the first-division lateral roots in the 10—30 cm soil layer.The fast-growing,well-developed root system and nodules provided the plant with superior drought resistance and ecological functions of improving soil quality and conserving soil and water.Compared with spring sowing,fall sowing agreed to local light,heat,and water resources better and should be promoted to a higher level.
Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report

Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour of the gastrointestinal tract with both epithelial and neuroendocrine components. We describe a case of a 57-year-old man who presented with yellow sclera and dark urine. Contrast-enhanced computed tomography (CT) showed enlargement of the intra and extrahepatic bile ducts and a neoplastic lesion at the end of the common bile duct which was indistinguishable from the adjacent head of the pancreas and duodenum. A pancreaticoduodenectomy was performed and histopathological examination of resected samples showed that tumour was a complex lesion with adenocarcinoma and neuroendocrine components positive for neuroendocrine markers (chromogranin A and synaptophysin) with a Ki-67 labelling index of 40%. The patient was diagnosed with MANEC in the ampulla of Vater with a neuroendocrine carcinoma component of approximately 70%. Ampullary MANECs are highly aggressive tumours with a high risk for distant metastases and a poor prognosis. Therefore, establishing a standard therapeutic strategy is crucial.
Perception versus Reality: The Relationship between Subjective and Objective Measures of Sleep When On-call under Simulated Laboratory Conditions

ABSTRACT Background On-call working arrangements have been shown to negatively impact sleep. However, workers may perceive their sleep to be worse than it actually is. The aim of this study was to compare participants’ pre- and post-sleep estimates of sleep duration and sleep quality with objectively measured sleep when on-call under laboratory conditions. Participants 72 healthy, adult males. Methods Analyses were performed on three interrelated studies, all of which consisted of four nights in a sleep laboratory. Following adaptation and baseline nights were two on-call nights (sleep opportunity 23:00 h – 07:00 h). Before and after each sleep opportunity, participants provided subjective estimates of sleep. Sleep was objectively measured using polysomnography. Results Estimated sleep duration (6.74 ± 1.13 h) and sleep onset latency (20.55 ± 14.85 min) were significantly poorer than objectively measured sleep outcomes (sleep duration 7.21 ± 1.25 h; sleep latency 13.20 ± 10.06 min). Of the variance in post-sleep estimated sleep duration, 14% was associated with objectively measured minutes of N3 (R2Δ = 0.55) and REM (R2Δ = 0.75). Additionally, 14% of post-sleep sleep quality estimation variance was associated with minutes of N2 (R2Δ = 0.60) and N3 (R2Δ = 0.79), measured by polysomnography. Conclusions Some objective measures of sleep were associated with subjective estimates of sleep duration and sleep quality. However, individuals may overestimate sleep onset latency and underestimate sleep duration during on-call periods. It may be beneficial for on-call workers to actively reflect on feelings of fatigue/alertness for workplace fatigue management, rather than relying solely on estimates of sleep.
Prognostic importance of atypical endometriosis with architectural hyperplasia versus cytologic atypia in endometriosis-associated ovarian cancer

Objective Patients with endometriosis are at increased risk of ovarian cancer. It has been suggested that atypical endometriosis is a precursor lesion of endometriosis-associated ovarian cancer (EAOC). The aim of this study is to evaluate if cytologic (cellular) atypia and architectural atypia (hyperplasia), histologic findings described as atypical endometriosis, play a different role in patients with EAOC. Methods A prospective study was conducted between January 2014 and April 2017 at our institution with patients undergoing surgery with a histologic diagnosis of endometriosis, ovarian cancer, or EAOC. The prevalence and immunohistologic study (Ki-67, BAF250a, COX-2) of cases of cellular and architectural atypia in endometriosis were analyzed. Results Two hundred and sixty-six patients were included: the diagnosis was endometriosis alone in 159 cases, ovarian cancer in 81, and EAOC in 26. Atypical endometriosis was reported in 23 cases (12.43%), 39.13% of them found in patients with EAOC. Endometriosis with cellular atypia was found mainly in patients without neoplasm (71.4%), and endometriosis with architectural atypia was seen in patients with ovarian cancer (88.9%) (p=0.009). Ki-67 was significantly higher in endometriosis patients with architectural atypia than those with cellular atypia. Conclusion The diagnosis of endometriosis with architectural atypia is important because it may be a precursor lesion of ovarian cancer; therefore, pathologists finding endometriosis should carefully examine the surgical specimen to identify any patients with hyperplasia-type endometriosis, as they may be at higher risk of developing EAOC.
Preliminary study on applicability of microsatellite primers developed from Crassostrea gigas to genomic analysis of Hyriopsis cumingii

Hyriopsis cumingii, which produces pearl ofthe highest quality, is a kind of freshwater species unique in China. The development of microsatellite markers of H. cumingii has not been reported.However, many microsatellite markers have been developed from Crassostrea gigas. The conservativeness of the side sequences of the microsatellite in species of close genetic relationship has already been discovered. In order to determine the applicability of microsatellite primers developed from C. gigas to genomic analysis in H. cumingii, 32 polymorphic microsatellite primers identified in the Pacific oyster were employed to amplify in the genome of mussel. The conditions of polymerase chain reaction(PCR) were optimized for the fidelity of DNA synthesis during PCR amplification. It was found that 19 loci failed to be amplified and 13 loci (about 41%) amplified specific products successfully. Among 13 loci, 3 (Cgi-6, Cgi-27and Cgi-28) were monomorphic and 10 (about 31%) (Cgi-1,Cgi-10,Cgi-18,Cgi-22,Cgi-24,Cgi-25, Cgi-26, Cgi-29, Cgi-30 and Cgi-32) were polymorphic.The analysis of the genetic diversity showed the average heterozygosity of 10 microsatellites loci of H. cumingii ranged betwen 0.125 and 0.693 and 7 loci (Cgi-10, Cgi-22, Cgi-24, Cgi-26, Cgi-29, Cgi-30, Cgi-32 ) are high polymorphic(He0.500), whereas 3 loci (Cgi-1, Cgi-18 and Cgi-25 ) are low polymorphic(He0.500). This study confirmed that 10 Pacific oyster pimers could be used for the analysis of the genetic diversity in H. cumingii. This result showed some of the microsatellite primers can be used for genetic analysis of mussel without high coat costing and time consuming. And it suggested that this method could be useful in genetic analysis of other species of mussel.
Deep Spatio-Temporal Representation and Ensemble Classification for Attention Deficit/Hyperactivity Disorder

Attention deficit/Hyperactivity disorder (ADHD) is a complex, universal and heterogeneous neurodevelopmental disease. The traditional diagnosis of ADHD relies on the long-term analysis of complex information such as clinical data (electroencephalogram, etc.), patients’ behavior and psychological tests by professional doctors. In recent years, functional magnetic resonance imaging (fMRI) has been developing rapidly and is widely employed in the study of brain cognition due to its non-invasive and non-radiation characteristics. We propose an algorithm based on convolutional denoising autoencoder (CDAE) and adaptive boosting decision trees (AdaDT) to improve the results of ADHD classification. Firstly, combining the advantages of convolutional neural networks (CNNs) and the denoising autoencoder (DAE), we developed a convolutional denoising autoencoder to extract the spatial features of fMRI data and obtain spatial features sorted by time. Then, AdaDT was exploited to classify the features extracted by CDAE. Finally, we validate the algorithm on the ADHD-200 test dataset. The experimental results show that our method offers improved classification compared with state-of-the-art methods in terms of the average accuracy of each individual site and all sites, meanwhile, our algorithm can maintain a certain balance between specificity and sensitivity.
Recent Molecular Evolution of Human Metapneumovirus (HMPV): Subdivision of HMPV A2b Strains

Human metapneumovirus (HMPV) is a major etiological agent of acute respiratory infections in humans. HMPV has been circulating worldwide for more than six decades and is currently divided into five agreed-upon subtypes: A1, A2a, A2b, B1, and B2. Recently, the novel HMPV subtypes A2c, A2b1, and A2b2 have been proposed. However, the phylogenetic and evolutionary relationships between these recently proposed HMPV subtypes are unclear. Here, we report a genome-wide phylogenetic and evolutionary analysis of 161 HMPV strains, including unique HMPV subtype A2b strains with a 180- or 111-nucleotide duplication in the G gene (nt-dup). Our data demonstrate that the HMPV A2b subtype contains two distinct subtypes, A2b1 and A2b2, and that the HMPV subtypes A2c and A2b2 may be different names for the same subtype. HMPV A2b strains with a nt-dup also belong to subtype A2b2. Molecular evolutionary analyses indicate that subtypes A2b1 and A2b2 diverged from subtype A2b around a decade after the subtype A2 was divided into the subtypes A2a and A2b. These data support the A2b1 and A2b2 subtypes proposed in 2012 and are essential for the unified classification of HMPV subtype A2 strains, which is important for future HMPV surveillance and epidemiological studies.