Miracle-dz/UniFAR-FTUs huggingface dataset:
Laboratory investigations on the low pathogenic potential of Plesiomonas shigelloides

The pathogenic properties of 16 Plesiomonas shigelloides strains recovered from humans with extraintestinal and intestinal illnesses, infected animals, and environmental sources were investigated. Most strains possessed a high cell charge and low surface hydrophobicity analogous to those of Shigella spp. ; additionally, serogroup O:17 strains reacted with Shigella group D antisera. However, unlike the shigellae, P. shigelloides strains did not universally bind Congo red, were noninvasive in HEp-2 cell assays, and did not produce a Shiga-like toxin on Vero cells. On HEp-2, Y1, and possibly Vero cells, a low-level cytolysin was consistently produced by all 16 P. shigelloides strains when grown in either Evan Casamino Acids-yeast extract or Penassay broth. The median 50% lethal dose for all 16 P. shigelloides strains in outbred Swiss Webster mice was 3.5 x 10(8) CFU (range, 3.2 x 10(7) to greater than 1 x 10(9) CFU). Animal pathogenicity did not correlate with cytolysin expression, possession of a greater than or equal to 120-MDa plasmid, protein profile, or resistance to complement-mediated lysis. No strain analyzed produced siderophores or a heat-stable enterotoxin. The results suggest that members of the genus Plesiomonas have an overall low pathogenic potential, irrespective of the site of isolation or phenotypic, serologic, or surface properties shared with other traditional enteropathogens.
Analysis of Multi-junction PV cells

As the demand of the renewable energy sources is increasing tremendously due to the lack of fuel reserves. So we are trying to move towards the renewable sources and among all the renewable sources, solar energy is the most important and has large potential with environment friendly. This paper presents the idea of Multi-junction solar cell and their simulation on MATLAB. A comparison is made between conventional single-junction and multi-junction PV cell by comparing its maximum power point and open circuit voltage. In this paper, triple junction PV cell has taken which includes InGaP, InGaAs, Ge subcells. The various criterion used for selecting the material for making the multi-junction PV cell is also listed by the author.
International Consensus Conference on High-Dose Therapy with Hematopoietic Stem Cell Transplantation in Aggressive Non-Hodgkin's Lymphomas: report of the jury.

In theintervening years, a number of randomized studies havebeen completed that address important questions regardingthe role of high-dose therapy with stem-cell support (HDT)in the aggressive non-Hodgkin’s lymphomas (NHLs). Forthis reason, the original consensus conference organizersconvened a second International Consensus Conference onHigh-DoseTherapywithHematopoieticStemCellTransplan-tation in Aggressive Non-Hodgkin’s Lymphomas in April1998 and charged a jury with the task of evaluating availabledata on when and how to perform HDT in these diseases(Table 1). The jury operated under standard consensusconference guidelines. For each question regarding HDT inaggressive NHLs, the jury made a positive or negativerecommendation or indicated that there were insufficientdata to make a recommendation (Table 1). The quality of theevidence supporting each recommendation was also evalu-ated according to standard accepted criteria (Table 2).
VASCULAR TRAUMA IN THE AMAZON REGION: A TWO YEARS CASES REVIEW FROM A SINGLE INSTITUTION

Introduction: Vascular injuries are among the main mechanisms of death in trauma. In Brazil, the general surgeon is in charge of emergencies procedures in most hospitals, but many times these surgeons are not familiarized with more complex vascular surgical techniques that often require a vascular surgeon. Para State is the most populated one in the Brazilian Amazon region and a single hospital with vascular surgeons permanently on call is available. Objectives: To evaluate demographic data on vascular trauma victims; to establish the mechanism, anatomic location, injury pattern and surgical techniques used to manage the vascular lesions treated at the Metropolitan Emergency Hospital; to ascertain associated non-vascular injuries and victim’s clinical outcome. Methods: Medical records retrospective analysis of patients treated for vascular injuries from February 2011 to February 2013 at the institution in case. All arterial and venous injuries were analyzed. Patients who were not operated by the vascular surgery team, iatrogenic injuries and those who underwent primary or sustained traumatic amputation were excluded. Results: 173 cases; 95.95% were male; 54.90% were between 25 and 49 years; penetrating trauma mechanisms were found in 88.44%; lower limb was the most affected topography (41.50%); the most injured vessels were the superficial femoral and ulnar arteries (in 15.75% of cases each) and the superficial femoral vein (17.77%); autologous vein graft was the most performed technique for arterial repair (36.57%) and ligature was performed in 85.00% of venous trauma; amputation rate was 15.60% and mortality rate was 6.35%. Conclusions: Vascular injuries occurred predominantly in men from 24 to 49 years old; penetrating mechanisms were most frequent; lower limb was the most affected topography; the most frequently injured vessels were the ulnar and superficial femoral arteries and the superficial femoral vein; complete vessel transection was the most common injury pattern; arterial trauma was most frequently treated by autologous venous graft interposition and ligature was performed for most of venous injuries; fractures were the most common associated lesions; the majority of patients recovered uneventfully, ischemic and infectious complications were the most frequent ones; deaths were caused by hypovolemic and septic shocks.
The role of consciousness in attentional control differences in trait anxiety

Trait anxiety has long been associated with impaired selective attention to task-irrelevant threat stimuli, both when threat is presented consciously and outside of awareness. However recent research has suggested broader deficits in selective attention, with poorer ability to ignore supraliminal non-emotional information in anxiety. Here, we investigated whether anxiety could equally be associated with poorer selective attention for non-emotional stimuli in a subliminal context. Participants performed a simple arrow discrimination task, where prior incompatible or compatible response primes were presented before targets either unmasked (supraliminal) or masked (subliminal). While distractor interference was evident in both conditions, trait anxiety was associated with increased task-irrelevant processing only in the supraliminal condition; group effects were eliminated when primes were masked. Our findings are in line with traditional accounts suggesting that differences in selective attention and cognitive control solely modulate conscious distractor processing.
In vivo measurement of the size of lipid droplets in an intracerebral glioma in the rat

Pulsed field gradient NMR was used to measure the root mean square displacement λ of the NMR visible lipid molecules in C6 brain tumors in the rat at different diffusion times. For a distribution of spherical droplets of diameter with volume fraction ξ(Φi), the mean characteristic droplet diameter Φc = was shown to be related to the root mean square displacement at long diffusion times by the simple relationship Φ 2c = 10λ2. In the range of diffusion times 100–530 msec, λ was found to be independent of the diffusion time and equal to 1.35 ± 0.22 μm and Φc to 4.27 ± 0.71 μm. The data reinforce the notion that the presence of lipid resonances in NMR spectra of tumors is due to lipid droplets. Light microscopy of histologic slices showed the presence of lipid droplets mainly in the necrotic region and in a layer of tumor cells surrounding the necrosis. Magn Reson Med 45:409–414, 2001. © 2001 Wiley‐Liss, Inc.
Characterization of Single-Photon Time Resolution: From Single SPAD to Silicon Photomultiplier

In this paper, we report on the characterization of the single-photon time resolution (SPTR) of the RGB (Red-Green-Blue) type silicon photomultipliers (SiPM) produced at FBK. We measured and compared single-photon timing jitter of 1 ×1 mm2 and 3 ×3 mm2 SiPMs, and also of square SPADs with integrated passive quenching, identical to the cells composing the SiPMs. We reached a single-photon time resolution of about 180 ps full-width at half-maximum for 3 ×3 mm2 SiPM, 80 ps for 1 ×1 mm2 SiPM and less than 50 ps for single cells. From measurements with pinholes placed in front of 1 ×1 mm2 detector we see a very good cell-to-cell uniformity: it is not a limiting factor for time resolution. We also characterized the timing jitter of SiPMs as a function of the number of photons per laser pulse (N) finding that it does not decrease exactly with the square root of N because of the optical crosstalk between cells.
Optimal Frequency Value to Detect Low Current Faults Superposing Voltage Tones

Single phase to ground low current faults (LCF) are difficult to be detected with common fault detection techniques. Therefore, several specific methodologies have been developed to identify LCF in an easier way. Among these methodologies, a method based on superposing voltage tones has been proposed. This method requires defining the frequency of the tones that have to be superimposed.
The control of Glossina morsitans morsitans (Diptera: Glossinidae) in a settled area in Petauke District (Eastern Province, Zambia) using odour-baited targets

VAN DEN BOSSCHE, P. 1997. The control of Glossina morsitans morsitans (Diptera: Glossinidae) in a settled area in Petauke District (Eastern Province, Zambia) using odour-baited targets. Onderstepoort Journal of Veterinary Research, 64:251-257 A trial to control G. m. morsitans with the use of 980 odour-baited, insecticide-impregnated targets was conducted in a 300 km 2 area in the Eastern Province of Zambia between 1989 and 1991 . The area is highly cultivated and cattle density is high (about 8 cattle/km 2 ). Targets were deployed along roads and tracks. Deployment was restricted to su itable tsetse habitat. The effect of the targets on the tsetse population and on the transm ission of tsetse-transmitted trypanosomosis was monitored by means of man-walked fly rounds and sentinel herds, respectively. The apparent density of tsetse in the trial area and in adjacent areas, declined rapidly after targets had been deployed. Trypanosomosis incidence in the trial area decreased significantly but did not completely disappear. Results from the trial show that odour-baited targets are effective in controlling Glossina m. morsitans in highly cultivated areas even when deployment is restricted to suitable tsetse habitat. It is co n­ cluded that tsetse control operations should be chosen such that either the invasion pressure is low from adjacent areas, or the size of the area is big enough, so that a central challenge-free area can be created.
Heterologous Human Immunodeficiency Virus Type 1 Lentiviral Vectors Packaging a Simian Immunodeficiency Virus-Derived Genome Display a Specific Postentry Transduction Defect in Dendritic Cells

ABSTRACT Heterologous lentiviral vectors (LVs) represent a way to address safety concerns in the field of gene therapy by decreasing the possibility of genetic recombination between vector and packaging constructs and the generation of replication-competent viruses. Using described LVs based on human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus MAC251 (SIVMAC251), we asked whether heterologous virion particles in which trans-acting factors belonged to HIV-1 and cis elements belonged to SIVMAC251 (HIV-siv) would behave as parental homologous vectors in all cell types. To our surprise, we found that although the heterologous HIV-siv vector was as infectious as its homologous counterpart in most human cells, it was defective in the transduction of dendritic cells (DCs) and, to a lesser extent, macrophages. In DCs, the main postentry defect was observed in the formation of two-long-terminal-repeat circles, despite the fact that full-length proviral DNA was being synthesized and was associated with the nucleus. Taken together, our data suggest that heterologous HIV-siv vectors display a cell-dependent infectivity defect, most probably at a post-nuclear entry migration step. As homologous HIV and SIV vectors do transduce DCs, we believe that these results underscore the importance of a conserved interaction between cis elements and trans-acting viral factors that is lost or suboptimal in heterologous vectors and essential only in the transduction of certain cell types. For gene therapy purposes, these findings indicate that the cellular tropism of LVs can be modulated not only through the use of distinct envelope proteins or tissue-specific promoters but also through the specific combinatorial use of packaging and transfer vector constructs.
Roles of immunohistochemical staining in diagnosing pulmonary squamous cell carcinoma.

BACKGROUND Differentiating morphologic features based on hematoxylin-eosin (HE) staining is the most common method to classify pathological subtypes of non-small-cell lung cancer (NSCLC). However, its accuracy and inter-observer reproducibility in pathological diagnosis of poorly differentiated NSCLC remained to be improved. MATERIALS AND METHODS We attempted to explore the role of immunohistochemistry (IHC) staining in diagnosing pulmonary squamous cell carcinoma (SQCC) with poorly differentiated features by HE staining or with elevated serum adenocarcinoma-specific tumor markers (AD-TMs). We also compared the difference of epidermal growth factor receptor (EGFR) mutation rate between patients with confirmed SQCC and those with revised pathological subtype. Logistic regression analyses were used to test the association between different factors and diagnostic accuracy. RESULTS A total of 132 patients who met the eligible criteria and had adequate specimens for IHC confirmation were included. Pathological revised cases in poor differentiated subgroup, biopsy samples and high-level AD-TMs cases were more than those with high/moderate differentiation, surgical specimens and normal-level AD-TMs. Moreover, biopsy sample was a significant factor decreasing diagnostic accuracy of pathological subtype (OR, 4.037; 95% CI 1.446-11.267, p=0.008). Additionally, EGFR mutation rate was higher in patients with pathological diagnostic changes than those with confirmed SQCC (16.7% vs 4.4%, p=0.157). CONCLUSIONS Diagnosis based on HE staining only might cause pathological misinterpretation in NSCLC patients with poor differentiation or high-level AD-TMs, especially those with biopsy samples. HE staining and IHC should be combined as pathological diagnostic standard. The occurrence of EGFR mutations in pulmonary SQCC might be overestimated.
A millimeter-wave conformal phased microstrip antenna array on a cylindrical surface

The work presents a design of a cylindrical conformal phased microstrip antenna array. Based on the HFM and the parallel feed network, a conformal microstrip 2 times 8 array on a cylinder surface is designed by the isotropic transformation theory (IT). Simulation results show that the conformal array works at 35GHz and the gain is 19.6dB at the center frequency. The phase-scanned patterns of the conformal 2 times 8 array are analyzed by the CST using phase control method. From the comparison of the scanning results at different phase division, it can be found that the scan angle, the angular width and the side lobe level varies following the trends of the phase division, at the same time, the gain of the conformal array changes markedly opposite the trends of the phase division. Therefore, this is a shortcoming of the conformal phased array. This kind of conformal phased sub-array can be easily expanded into a large-scale conformal array and be suitable for active integration with other microwave circuits and communication systems if this disadvantage was eliminated after further discussion in future.
An application of real-time control systems to robotics

This paper illustrates basic concepts of real-time control systems through the application of a real-time single-processor computing environment for the control of a robotic arm. The paper describes elements for the selection of the real-time architecture, the control algorithm and the graphical user interface. The system provides an opportunity for users to verify the robot performance by changing on-line the controller parameters and the shape of the desired motion.
Detección de vocales mediante modelado o de clusters de fonemas

Many speech signal processing systems require the detection of regions of stability within the signal. As vowels form great stability regions, a system capable of detecting them automatically in the speech is very convenient. This work presents such a system, which uses HMM models of phonetic clusters created according to the acoustic similarities among the phonemes. These clusters are the key element for the system to work correctly in different languages. Although models were trained in Basque, tests were carried out in both Basque and German speech databases showing that the system is able to detect the vowels and their boundaries with acceptable accuracy in both languages.
Approximate Judgement Aggregation November 15 , 2011

In this paper we analyze judgement aggregation problems in which a group of agents independently votes on a set of complex propositions that has some interdependency constraint between them (e.g., transitivity when describing preferences). We consider the issue of judgement aggregation from the perspective of approximation. That is, we generalize the previous results by studying approximate judgement aggregation. We relax the main two constraints assumed in the current literature, Consistency and Independence and consider mechanisms that only approximately satisfy these constraints, that is, satisfy them up to a small portion of the inputs. The main question we raise is whether the relaxation of these notions significantly alters the class of satisfying aggregation mechanisms. The recent works for preference aggregation of Kalai, Mossel, and Keller fit into this framework. The main result of this paper is that, as in the case of preference aggregation, in the case of a subclass of a natural class of aggregation problems termed ‘truth-functional agendas’, the set of satisfying aggregation mechanisms does not extend non-trivially when relaxing the constraints. Our proof techniques involve boolean Fourier transform and analysis of voter influences for voting protocols. The question we raise for Approximate Aggregation can be stated in terms of Property Testing. For instance, as a corollary from our result we get a generalization of the classic result for property testing of linearity of boolean functions.
Multiscale image analysis method for urban applications

Urban is composed of different critical levels of organization where interactions are stronger within levels than among levels, it is a complex system. Image analysis performed at a unique scale for urban applications is doomed to be incomplete and misleading. This paper presents a multiscale image analysis method based on wavelet transform and watershed transform for urban system. It performs image analysis on multiple scale images, and can catch comprehensive information of urban system for different applications. The procedure consists of three main steps: multiscale representation, image segmentation, post-processing. First, multiscale represent creates multiresolution images using a wavelet transform and a modified inverse wavelet transform; a smooth and multiscale presentation of original image is provided. Second, image segmentation segments the multiscale images using watershed segment algorithm. Finally, post-processing merges over-segment regions and smoothes watersheds, then, multiscale image objects are attained. This study was conducted in Nanjing, Jiangsu province, China, using IKONOS satellite data. Experimental results demonstrate that the proposed method is suitable for describing the complex urban system. Both visual and quantitative methods are applied to evaluation the experimental results, and reveal the relation of objects within and among levels.
Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells

Integration of human papillomavirus type 16 (HPV-16) DNA into a host chromosome has been hypothesized to result in altered expression of two viral transforming genes, E6 and E7, in cervical cancers. In order to investigate the role that changes in viral genomic state and gene expression play in cervical carcinogenesis, we have derived clonal populations of human cervical epithelial cells which harbor multiple copies of either extrachromosomal or integrated viral DNA. The clonal populations harboring extrachromosomal HPV-16 DNA stably maintained approximately 1,000 viral copies for at least 15 passages (approximately 100 cell doublings), which contrasted with the unstable HPV-16 replicons in the parental counterpart. In the clonal populations harboring integrated viral DNA, 3 to 60 copies of HPV-16 DNA were found integrated in either of two forms: type 1, in which all the copies of HPV-16 DNA were disrupted in the E2 open reading frame upon integration, and type 2, in which intact viral copies were flanked by disrupted viral copies and cellular sequences. Despite the lower HPV-16 DNA copy number, the clonal populations with integrated viral DNA had levels of E7 protein that were in most cases higher than those found in the clonal populations harboring extrachromosomal viral DNA. Irrespective of viral genomic state, the clonal populations were capable of undergoing terminal differentiation and unable to form colonies in soft agar, which is indicative of the nontumorigenic nature of these cells. Importantly, a cell population with integrated viral DNA was found to outgrow another with extrachromosomal DNA when these cells were cocultured over a period of time. Thus, integration of human papillomaviral DNA correlates with increased viral gene expression and cellular growth advantage. These observations are consistent with the hypothesis that integration provides a selective advantage to cervical epithelial precursors of cervical carcinoma.