Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment for ischaemic stroke within an unknown time window: how much imaging do we need?

In up to 25% of all ischaemic strokes the exact symptom onset time can not be determined (stroke with unknown onset; SUO). This is either because of unwitnessed stroke in patients unable to communicate or by stroke on awakening. However, patients may have had their stroke just before waking-up (or being found) and others may display salvageable tissue despite being in an extended time window. Thus thrombolysis may be beneficial in this patient population. Besides several pilot studies [1,2] no large randomized controlled trials (RCT) have been conducted to prove this assumption and intravenous thrombolysis (IVT) in this subgroup remains off-label . In the planning of RCTs for SUO there is an ongoing debate on what kind of imaging is required to select patients who are clinically eligible for thrombolysis. Several fundamentally different approaches for such RCTs are conceivable each requiring different imaging protocols. Vice versa the chosen imaging approach directly influences the study planning i.e. power and sample size calculations. In the followingwewould like to present3 escalation levels of imagingprotocols for sucha trial:
A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms

Significance For proteins to be able to have context-specific activities, they can adopt context-specific conformations that enhance or restrict their activity. For transcriptional regulatory factors, such a context-specific signal is provided by the sequence of the DNA response element to which it binds. Here we show how one signal, an alternative splicing event, rewires a transcriptional regulatory protein to respond differently to a second signal, the DNA sequence to which it binds, by changing the functional interplay between protein domains. Together, our findings argue that bidirectional allosteric signaling between the DNA:protein interface and other regulatory domains fine tunes the activity of transcriptional regulatory factors toward individual target genes. In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by a single amino acid insertion in the lever arm, a domain that adopts DNA sequence-specific conformations. We show that these isoforms differentially regulate gene expression levels through two mechanisms: differential DNA binding and altered communication between GR domains. Our studies suggest a versatile role for DNA in both modulating GR activity and also in directing the use of GR isoforms. We propose that the lever arm is a ”fulcrum” for bidirectional allosteric signaling, conferring conformational changes in the DNA reading head that influence DNA sequence selectivity, as well as conferring changes in the dimerization domain that connect functionally with remote regulatory surfaces, thereby influencing which genes are regulated and the magnitude of their regulation.
Line managers' engagement in support of employees' development : a study within the oil and gas industry

Line managers who are involved with employees on a daily basis are in a unique position to support their subordinate employees’ development. However, organisations have found that achieving the required engagement from line managers is not straightforward. This particular study embraced a framework based on the Job DemandsResources model to help understand what are the factors most influencing line managers’ engagement in support of subordinate employees’ development. Through a mixed methodology approach, combining a questionnaire instrument and focus group discussions with line managers and other stakeholders within an organisation operating in the Oil and Gas industry, this study identified several findings that have implications on different levels. The results of the study indicated that organisation factors were perceived by line managers as being more important than both opportunity factors and motivation factors and that organisation factors moderate the impact of the ability, opportunity and motivation factors. In addition, it was found that organisation factors can moderate individual/contextual variables and also that certain individual/contextual variables may moderate organisation, opportunity and motivation factors.
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities

The biochemical properties of four acyclovir-resistant mutants are described. Two of these mutants, PAAr5 and BWr, specified nucleotidyl transferase (DNA polymerase) activities which were less sensitive to inhibition by acyclovir triphosphate than their wild-type counterparts. Another mutant, IUdRr, exhibited reduced ability to phosphorylate acyclovir. The fourth mutant, ACGr4, both induced an altered DNA polymerase and failed to phosphorylate appreciable amounts of acyclovir. BWr, a new acyclovir-resistant mutant derived from the Patton strain of herpes simplex virus type 1, induced a DNA polymerase resistant to inhibition by acyclovir triphosphate, but, unlike the polymerases induced by PAAr5 and ACGr4, still sensitive to phosphonoacetic acid. Resistance of BWr to acyclovir mapped close to the PAAr locus and was separable from mutations in the herpes simplex virus thymidine kinase gene by recombination analysis.
Impact of Quality Management on Hospital Performance: An Empirical Examination

Understanding the impact of quality management approaches on organization performance is essential in the healthcare arena. Prior research, however, is inconsistent in regard to the link between various quality management practices and firm performance. That is, some researchers find a strong link between quality management and firm performance, while others do not. The authors believe the use of causal models and an expansive view of quality management may help to bridge these opposing viewpoints or perspectives. To that end, the current research “decomposes” the construct of quality management into two subdimensions of quality practices and quality context, providing a richer conceptualization and understanding of the overall construct. Additionally, they employ structural equation modeling to evaluate the causal sequence showing that both quality practices and quality context are distinct model components concurrently operating through the endogenous construct of quality management to positively impact hospital performance. The implications for hospital managers and executives are clear: in order to improve hospital performance, the scope of the organization's quality activities need to be very broad and encompassing. Last, the authors assess the potential moderating effects of environmental uncertainty and hospital size on the quality management-performance relationship.
Mobile Customer Relationship Management : A study of barriers and facilitators to mCRM adoption

Managing customer relations had become a necessity for companies who want to succeed in today’s customer oriented market. New systems are developed that allow firms to manage and govern their relationships to the customers. These applications are called Customer Relationship Management (CRM) Systems and have become one of the most widely adopted business solution in the private sector. In the mean time, mobile internet and mobile marketing have become two of the most popular subjects mentioned in business literature today.A new system that combines CRM and mobile technologies has recently been developed: mobile CRM (mCRM). This type of system will allow companies to enhance their way of working with customer relations and enables new ways of offering value to customers. The market size of mCRM systems has grown from a $120 million industry in 2001 to a $1, 7 billion industries in 2005. The combination of the growing trend of customer focus, mobile technologies and mCRM systems will most likely lead to more companies investing in mCRM solutions. Still an interesting question of the reasons behind mCRM adoption remains unanswered. The main focus of this thesis is to find out why companies chose to adopt or not adopt mCRM systems.Theories about CRM, mCRM and the spreading of technology (The Technology Acceptance Model) have been gathered and examined in order to support the research. After a gained insight of the subject matter, a methodology is discussed explaining research approach. A qualitative approach is used and interviews are conducted in order to find barriers and facilitators to mCRM adoption. Four companies from different industry sectors where interviewed, answering to questions concerning their level of IT adoption, CRM strategy and perception of mCRM.The research resulted in several reasons for mCRM acceptance and rejection. The primary reason for investing mCRM, or considering investing in mCRM, was found to be the need to reach customers and sales force anytime and anywhere. Also, current IT adoption and IT dependency, as well as industry sector, are found to influence attitude towards mCRM. Factors that are found not to affect mCRM adoption are size of the firm and external pressure from the market. The overall perception of mCRM is positive among the respondents and all believe that the mobility aspect of CRM will become increasingly popular.
Is the Quality of Service Related to Job Satisfaction? Study of Commercial Banks of Sukkur Region, Sindh, Pakistan

Study of quality of service and job satisfaction in commercial banks is not carried out before in Pakistan, so because of the competitive environment and saturation of markets financial service providers are of the opinion that they want to add the value in their services for which they can improve the job satisfaction level which again linked with their market share, in this connection study was carried out from the commercial banks working in the Sukkur region, data collected through designing a questionnaire and analyzed through SPSS. 16. Finally concluded that service quality is highly correlated with the job satisfaction of employees, it is also positively and significantly related to the job satisfaction.
Patient–family EoL communication and its predictors: Reports from caregivers of Latino patients in the rural U.S.–Mexico border region

Abstract Objective: Family caregivers play an important role in end-of-life (EoL) decision making when the patient is unable to make his/her own decisions. While communication about EoL care between patients and family is perhaps a first step toward advance care planning (ACP)/EoL decisions, not every culture puts great value on open communication about this topic. The aims of the present study were to explore EoL communication and the aspects of communication among caregivers of Latino patients in the rural United States (U.S.)–Mexico border region. Method: This study analyzed data from a hospice needs assessment collected from 189 family caregivers of Latino patients at a home health agency in a rural U.S.–Mexico border region. Bivariate tests and logistic regression were used to address our aims. Results: About half of the family caregivers (n = 96, 50.8%) reported to have ever engaged in EoL discussion with patients. Significant predictors of EoL discussion included life-sustaining treatment preference (odds ratio [OR] = 0.44, p < 0.05); knowledge of an advance directive (AD) (OR = 5.50, p < 0.01); and distrust of physicians (OR = 0.29, p < 0.01). Caregivers who preferred extending the life of their loved one even if he/she had to rely on life supports were less likely to engage in EoL communication. Also, caregivers who worried that physicians might want to stop treatments (i.e., “pull the plug”) too soon were less likely to do so. Conversely, caregivers who had knowledge about ADs were more likely to engage in EoL communication. Significance of Results: EoL communication is a complex process influenced by individual, social, and cultural values and the beliefs of both the patient and his/her family. Inclusion of family caregivers in the ACP process and facilitating culturally tailored EoL communication between patients and family caregivers is important.
Optimising sensor placement for site-specific RSSD geolocation systems

Geolocation of wireless emitters using Received Signal Strength Difference (RSSD) and site-specific propagation models offers the advantages of increased accuracy and operation with non-cooperative emitters (where emitted power level or positional information such as GPS from the emitter is unavailable) over more commonplace Received Signal Strength (RSS) systems. An important factor influencing the accuracy of such systems is the physical arrangement of the sensors, making optimising the layout of sensors prior to deployment highly desirable. This paper introduces the novel Uniqueness metric for evaluating receiver layouts based on inter-point RSSD with a site-specific propagation model. Two optimization techniques (Monte Carlo optimization and an implementation of a genetic algorithm) are applied to the metric and evaluated in a case study that incorporates two different propagation environments (urban and rural) compared against an existing dilution of precision based metric. The results of the simulation demonstrate that the uniqueness metric combined with the genetic algorithm provide the best overall performance in both environments tested.
Cyberbullying Perpetration: A Meta-Analysis of Gender Differences

A total of 39 articles, which reported cyberbullying behaviors from both male and female respondents, were meta-analyzed to examine if gender difference existed in cyberbullying perpetration. From these 39 empirical studies, a total of 100 effect sizes were collected, each representing a reported gender difference in certain types of cyberbullying behaviors. Random-effects meta-regression models were used in data analysis. Despite some inconsistencies across the individual empirical studies, a statistically significant gender difference emerged, indicating that more males were involved in cyberbullying perpetration behaviors than females. Moderator analysis showed that the gender difference was not consistent across the levels of several study features (e.g., modality of cyberbullying, regions of samples). It was also revealed that some methodological issues (e.g., measurement of cyberbullying behaviors, self-report rather than behavioral data) remain obvious challenges for researchers in this area. Caution is warranted, because those studies that were rated as having poor study quality showed a larger than average effect size for gender difference in cyberbullying behaviors. Implications and future research directions are discussed.
The Adoption of Building Information Modeling (BIM) For Procurement of Works in Ghana

The introduction of the Public Procurement Act in 2003 in Ghana is over ten years, however research has indicated that value for money was not being achieved in both government- and donor-financed procurement resulting in poor project performance. There is therefore the need to improve on the efficiency, timeliness, and quality of construction and maintenance work in many developing countries. The aim is to investigate the prospects of Building Information Modeling for implementation of procurement of works in Ghana. The following objectives were identified to be of paramount importance in achieving aforementioned aim: to conduct a comprehensive literature review on Building Information Modeling; to identify the benefits of Building Information Modeling on Procurement and determine barriers affecting the use of Building Information Modeling for procurement of works in Ghana. The research is qualitative; literature review was conducted to collect the data for barriers affecting the use of Building Information Modeling for sustainable procurement of works in Ghana and the level of awareness among the procurement professionals for works. A content analysis was conducted to identify the benefits of the use of Building Information Modeling procurement activities. From the study 30 factors were identified to be the barriers affecting the utilization of Building Information Modeling in Ghana. It was concluded that education of BIM as a subject be taught at the built environment departments of the tertiary institutions in Ghana.
The discovery after 94 years of the elusive female of a myrmecolacid (Strepsiptera), and the cryptic species of Caenocholax fenyesi Pierce sensu lato

Due to its extreme sexual dimorphism and disparate hosts, no female myrmecolacid has been matched to its conspecific male to date. Here, for the first time to our knowledge, a morphological description is given of the matched female and male myrmecolacid, Caenocholax fenyesi waloffi ssp. nov. from Veracruz, Mexico: the female parasitic in a cricket and the male parasitic in an ant. For examined segments of DNA, the male and female are identical. Male C. fenyesi Pierce sensu lato was described 94 years ago from Veracruz. The male from Texas USA, which, for the same DNA segments, shows 15% divergence from the morphologically identical male from Veracruz, is given subspecies status, and is named Caenocholax fenyesi texensis ssp. nov. The discovery of the female finally enables many interesting studies to be pursued, such as speciation in morphologically cryptic taxa, the sexes of which parasitize disparate hosts. Caenocholax fenyesi sensu lato may also be evaluated for biocontrol of the red imported fire ant, Solenopsis invicta Buren, which is a pest in the USA and Australia.
Improvement in androgenetic alopecia in 53–76‐year‐old men using oral finasteride

Twenty‐eight men with AGA, aged 53–76 years (mean, 65 years), were selected to participate in this trial from a double blind, placebo controlled, multicenter study of subjects with moderate symptoms of BPH. Patients received either finasteride 5 mg or placebo daily for 24 months. Hair counts were performed at entry to the study and at 6, 12, 18, and 24 months. Hair counts were made directly on the scalp in a circular target area 1 in in diameter, located in the center of a template. The template was applied in such a way that its counting window fell on the most balding scalp area, which remained the same for each patient. 11 At each hair counting session, patients were asked about side‐effects and questioned about their sex life. Time trend and differences between groups were examined using a one‐way (treatment) MANOVA with repeated measures (baseline, 6, 12, 18, and 24 months). Additional two‐tailed t‐tests were performed to compare the two groups at each point of time. P < 0.05 was considered to be significant.
Phase II trial of zanolimumab (HuMax‐CD4) in relapsed or refractory non‐cutaneous peripheral T cell lymphoma

The efficacy and safety of zanolimumab (HuMax‐CD4) in patients with relapsed or refractory peripheral T Cell lymphoma (PTCL) was evaluated. Twenty‐one adult patients with relapsed or refractory CD4+ PTCL of non‐cutaneous type (angioimmunoblastic T cell lymphoma (AITL) n = 9, PTCL‐not otherwise specified (NOS) n = 7, anaplastic large cell lymphoma (ALCL) n = 4 and enteropathy type T cell lymphoma n = 1) were treated in a single‐arm multi‐centre study, with weekly intravenous infusions of zanolimumab 980 mg for 12 weeks. Median age was 69 years (range 26–85). Seventeen of the patients had advanced stage disease (Ann Arbor stages III–IV). Objective tumour responses were obtained in 24% of the patients with two complete responses unconfirmed (CRu) and three partial responses (PR). One of the CRus lasted more than 252 d. Responses were obtained in different PTCL entities: AITL (n = 3), ALCL (n = 1) and PTCL‐NOS (n = 1). In general, the trial drug was well tolerated with no major toxicity. Zanolimumab at a dose of 980 mg weekly demonstrated clinical activity and an acceptable safety profile in this poor‐prognosis patient population, suggesting that the potential benefit combining zanolimumab with standard chemotherapy in the treatment of PTCL should be investigated.
A SOCIAL LAYER OF CUSTOMER TO CUSTOMER “VALUE CO-CREATION” AS AN ENGAGEMENT MARKETING TOOL: A TRANSFORMATION AT SOCIETAL LEVEL

Managerial interest in user-generated content (UGC) websites is growing, as firm face highly uncertain markets, ambiguous economic environments, and a mounting user base accustomed to active engagement rather than passive acceptance of products and services. Firms are now exploring ways to provide a platform (website) through which users generate and contribute content, resulting in a co-created experience between users and firms. This conceptual paper develops a framework of value co-creation in form of model by utilizing user experience as to examine how social interactions, operationalized as perceived as UGC website influence an individual’s user experience and subsequent engagement behaviors. Various social sites are availed by the consumers to share their experiences and suggest their viewpoints, which a firm could use as a platform to create innovation in their firms and could achieve better competitive advantage by satisfying consumers. Positive user experience positively influenced a user’s engagement behavior. Based on the results of this study, implications for research and practice are discussed and future directions for researchers are outlined. This papers also outlines the transformation coming in firms working by utilizing social layer.
A multiclass boosting approach for integrating weak classifiers in parking space detection

Recently, Huang's method [1] has proposed to use a 3D parking space representation for parking space detection. Following a generative process, the approach treats a parking lot as the collection of many parking spaces. Each space is modeled by a 3D cube. Each 3D cube is composed of multiple 3D surfaces. If projecting those 3D surfaces onto the image, many image patches of a parallelogram shape would be determined; each patch may reveal some weak information that could be used to infer the parking status. In order to transfer the image feature into status information, the approach trained a weak classifier for each image patch. Finally, by combining these weak classifiers, this approach could well determine the parking status. However, we found that the system weights for combining the weak classifiers in Huang's method are manually selected. This might not be suitable since different classifiers usually have different class discriminative ability. To address the issue, we proposed a multiclass boosting method to incorporate these weak classifiers through a back-propagation learning process.