Miracle-dz/UniFAR-FTUs huggingface dataset:
El Comercio Intraindustrial agroalimentario argentino en la década de los noventa

El comercio internacional asiste a profundos cambios resultantes de la liberalizacion y apertura de la economia y la formacion de bloques comerciales, a los que se suma la complejidad e interdependencia que genera el creciente intercambio intraindustrial. En este contexto, el objetivo de este articulo es analizar la dinamica del comercio intraindustrial en el sistema agroalimentario argentino. Entre los principales resultados obtenidos cabe senalar que en la oferta exportable agroalimentaria argentina se distinguen dos grupos de bienes: el primero de ellos esta caracterizado por un comercio de indole interindustrial; el segundo es de caracter intraindustrial, aunque es incipiente y presenta diferentes magnitudes. El primero remite a un patron de insercion internacional basado en el principio de las ventajas comparativas, al mismo tiempo que mantiene una fuerte incidencia en la balanza comercial. El segundo esta circunscrito a ciertos rubros de la economia. Sin embargo, los valores en el alcanzados demuestran la posibilidad de operar con economias de escala, calidad y diferenciacion de producto, condiciones basicas para el logro de una estrategia de desarrollo de mediano y largo plazo. Ademas, se puede afirmar que el comercio intraindustrial para el sector agroalimentario y para el caso argentino es selectivo, tanto desde el punto de vista geografico como del economico.
Uncertainty analysis in the unavailability assessment using Generalized Stochastic Petri Net with fuzzy parameters

This paper handles the problem of uncertainty in assessment the safety systems using Generalized Stochastic Petri Nets (GSPN). The basic probabilities usually treated to define transition in petri nets (PNs) are substituted by fuzzy number. Experts represent the uncertainties regarding the parameters of the components of systems to assess the influence of this uncertainty on safety system unavailability. The used approach combining Generalized Stochastic Petri Nets (GSPN) and Fuzzy probability revealed how the uncertainty on parameters values of the system affects significantly the performance of system.
The Red Wine Polyphenol Resveratrol Shows Promising Potential for the Treatment of Nucleus Pulposus–Mediated Pain In Vitro and In Vivo

Study Design. Descriptive and mechanistic investigation of the anti-inflammatory and anticatabolic effect of resveratrol in intervertebral discs (IVDs) in vitro and of the analgetic effect in vivo. Objective. To determine whether resveratrol may be useful in treating nucleus pulposus (NP)–mediated pain. Summary of Background data. Proinflammatory cytokines seem to be key mediators in the development of NP-mediated pain. Patients with discogenic or radiculopathic pain may substantially benefit from anti-inflammatory substances that could be used in a minimal-invasive treatment approach. Resveratrol, a polyphenolic phytoalexin found in red wine exhibits anti-inflammatory effects in various cell types and tissues, but no data exists so far with regards to the IVD in the context of low back and leg pain. Methods. In part 1, the anti-inflammatory and anticatabolic effect of resveratrol was investigated in a cell culture model on interleukin 1&bgr; (IL-1&bgr;) prestimulated human IVD cells on the gene and protein expression level. In part 2, the molecular mechanisms underlying the effects observed upon resveratrol treatment were investigated (toll-like receptors, nuclear factor &kgr;B, sirtuin 1 (SIRT1), mitogen-activated protein (MAP) kinases p38/ERK/JNK). In part 3, the analgetic effects of resveratrol were investigated in vivo using a rodent model of radiculopathy and von Frey filament testing. All quantitative data were statistically evaluated either by Mann-Whitney U test or by one-way analysis of variance and Bonferroni post hoc testing (P < 0.05). Results. In vitro, resveratrol exhibited an anti-inflammatory and anticatabolic effect on the messenger RNA and protein level for IL-6, IL-8, MMP1, MMP3 and MMP13. This effect does not seem to be mediated via the MAP kinase pathways (p38, ERK, JNK) or via the NF-&kgr;B/SIRT1 pathway, although toll-like receptor 2 was regulated to a minor extent. In vivo, resveratrol significantly reduced pain behavior triggered by application of NP tissue on the dorsal root ganglion for up to 14 days. Conclusion. Resveratrol was able to reduce levels of proinflammatory cytokines in vitro and showed analgetic potential in vivo. A decrease in proinflammatory cytokines may possibly be the underlying mechanism of pain reduction observed in vivo. Resveratrol seems to have considerable potential for the treatment of NP-mediated pain and may thus be an alternative to other currently discussed (biological) treatment options.
Frisch scheme identification for dynamic diagonal bilinear models

The article addresses the problem of dynamic system identification in the errors-in-variables framework for a class of discrete-time time-invariant input–output bilinear models when subjected to a white input signal. The proposed algorithm is based on an extension of the bias-compensated least squares method and utilises the Frisch scheme equations to determine the parameter vector together with the variances of the input and output noise sequences. The appropriateness of the approach is analysed and its performance evaluated when compared to other errors-in-variables identification techniques by means of a Monte Carlo simulation. The results obtained demonstrate the accuracy of the proposed method and the performance in terms of noise robustness is also observed.
Tumor lysis syndrome with massive hyperphosphatemia and hyperuricemia

Tumor lysis syndrome (TLS) occurs when tumor cells release their contents into the bloodstream, typically in response to chemotherapy, leading to the characteristic findings of hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and acute kidney injury. Twinkle artifacts on renal ultrasound may indicate calcium phosphate deposits in such patients.
Freestanding GaN Resonant Gratings at Telecommunication Range

We theoretically and experimentally demonstrate a freestanding gallium nitride (GaN) resonant grating at telecommunication range. The optical responses of the freestanding GaN resonant gratings are analyzed by the rigorous coupled-wave analysis method. The freestanding GaN resonant gratings are validated on 850-nm freestanding membrane by a combination of electron beam lithography, fast atom beam, etching, and deep reactive ion etching. The polarization properties of such freestanding GaN resonant gratings are demonstrated in reflectance measurements, and the experimental results correspond well to the theoretical model. The strong resonant peaks show a clear dependence on the duty ratio under transverse magnetic polarization, and a promising resonant peak of the fabricated freestanding GaN resonant grating, in which the grating period P is 1500 nm, the grating height h is 230 nm, and the grating width is 280 nm, is observed at 1516.4 nm with a full-width at half-maximum of 4 nm.
Empagliflozin for Type 2 Diabetes Mellitus: An Overview of Phase 3 Clinical Trials

Introduction: Sodium glucose cotransporter 2 (SGLT2) inhibitors have a unique mecha-nism of action leading to excretion of glucose in the urine and subsequent lowering of plasma glu-cose. This mechanism is independent of β-cell function; thus, these agents are effective treatment for type 2 diabetes mellitus (T2DM) at theoretically any disease stage. This class should not confer an additional risk of hypoglycemia (unless combined with insulin or an insulin secretagogue) and has the potential to be combined with other classes of glucose-lowering agents. Empagliflozin is one of three currently approved SGLT2 inhibitors in the United States, and has shown a favorable benefit-risk ratio in phase 3 clinical trials as monotherapy and as add-on to other glucose-lowering therapy in broad patient populations. In addition to its glucose-lowering effects, empagliflozin has been shown to reduce body weight and blood pressure without a compensatory increase in heart rate. Moreover, on top of standard of care, empagliflozin is the first glucose-lowering agent to demonstrate cardiovas-cular risk reduction in patients at high risk of cardiovascular disease in a prospective outcomes trial: a 14% reduction in risk of the 3-point composite endpoint of death from cardiovascular causes, nonfa-tal myocardial infarction, or nonfatal stroke. Like other SGLT2 inhibitors, empagliflozin is associated with a higher rate of genital mycotic infections than placebo and has the potential for volume deple-tion–associated events. Conclusion: This review summarizes the empagliflozin phase 3 clinical trials program and its poten-tial significance in the treatment of patients with T2DM. Evidence from these clinical trials show re-ductions in glycated hemoglobin (–0.59 to –0.82%) with a low risk of hypoglycemia except when used with insulin or insulin secretagogues, and moderate reductions in body weight (–2.1 to –2.5 kg) and systolic blood pressure (–2.9 to –5.2 mm Hg), thus supporting the use of empagliflozin as mono-therapy or in addition to other glucose-lowering agents. In addition, evidence from the recent EMPA-REG OUTCOME study, which demonstrated relative risk reductions in major adverse cardiac events (14%), cardiovascular mortality (38%) and all-cause mortality (32%), as well as hospitalization for heart failure (36%), supports use of empagliflozin in patients with T2DM and increased cardiovascu-lar risk.
Préambule. De la technique comme contorsion

Courses a la virtuosite Nombreuses sont les pratiques qui ont genere, parfois en leur cœur et souvent en leurs marges, des programmes acrobatiques. Ces programmes ont generalement des finalites comparables. Il s’agit d’apprecier et d’evaluer l’excellence technique, d’explorer plus ou moins librement les possibilites d’un instrument ou de mettre a l’epreuve ses limites. De la musique a la jonglerie, de la prestidigitation a la voltige aerienne ou encore a la cascade a moto, rares sont les arts.
Small-signal model validation of a SEPIC converter based on the three-state switching cell in CCM using the PWM switch model

This paper describes the small-signal model of a dc-dc SEPIC (single-ended primary inductance converter) converter based on the three-state switching cell (3SSC) in continuous conduction mode (CCM) using the pulse-width modulation (PWM) switch model. Based on the premise that the 3SSC is composed of two two-state switching cells and has two active switches and two diodes, the aforementioned traditional modeling technique can be employed, thus allowing obtaining the transfer functions involving several variables. Using ac sweep in typical computer simulation software, it can be stated that the derived mathematical expressions are valid for both operating conditions of the 3SSC conditions i.e. overlapping and nonoverlapping modes. Finally, some results on the 3SSC-based SEPIC converter operating with average current mode control are properly presented and discussed.
Malignant transformation of human fibroblast strain MSU‐1.1 by v‐fes requires an additional genetic change

To determine whether the v‐fes oncogenc can malignantly transform human fibroblasts that have acquired an infinite life span and are partially growth‐factor‐independent, we trans‐fected cell strain MSU‐1.1 with a plasmid containing the v‐fes oncogene and a bacterial histidinol dehydrogenase gene. Of the 60 independent histidinol‐resistant clones isolated and assayed for v‐fes expression using a fes‐specific monoclonal antibody, 6 were found to express the v‐fes protein at a detectable level. When progeny cells from these 6 clones were further characterized, 3 of the 6 clonal populations exhibited a significant increase in the ability to form medium‐sized colonies in agarose, but none were tumorigenic in athymic mice. However, when the 6 populations were propagated for many generations, the same 3 populations acquired the ability to form very large colonies in agarose (± 100 μm in diameter) at a frequency of 2% to 17%, and formed malignant tumors in athymic mice. This suggests that an additional genetic change required for malignant transformation had been spontaneously acquired in 3 of the v‐fes ‐transformed cell strains. To determine whether the change or changes were the equivalent of an activated sis or ras proto‐oncogene, we transfected the v‐fes oncogene into derivative strains of MSU‐1.1 that express a transfected v‐sis, c‐H‐ras or c‐N‐ras oncogene, but that do not form tumors, and assayed the v‐fes‐expressing transfectants for tumorlgenicity. The results showed that when complemented either by a ras oncogene expressed at a somewhat enhanced level or by the v‐sis oncogene, v‐fes can supply the additional change required for malignant transformation.
What Makes Video Ads Viral: Quantifying the Impact of Marketer- and User-Generated Content

Past research on viral advertising focuses on the direct impact of MGC (i.e. Marketer-Generated Content) on the content viral ability. However, it is not clear how this impact of MGC takes place through the mediating effect of UGC (i.e. User-Generated Content) in this process. In this study, we examine the mechanism that makes a video ad viral by taking into account the impact of both MGC (i.e. video content) and UGC (i.e. video comments) in YouTube. AMT (Amazon Mechanical Turk) and Text-Mining Method are combined to extract the characteristics embedded in MGC and UGC.
Experimental fault assessment on multiphase PM generators with fractional-slot concentrated windings

In this paper, a fault assessment of a multiphase permanent magnet generator designed for `more electric engine' aeronautic applications is presented. The distribution of various electrical faults occurring in three-phase machines that is available in the literature helped the authors to identify the most probable fault types. The six-phase machine under observation is tested under these faults both in Finite Element Analysis (FEA) as well as experimentally. In the experimental analysis, the generator supplies a resistive load through rectifier bridges when faults are introduced at its terminals. For a variety of fault situations, the measured machine response is compared with the finite element results in order to validate the accuracy of the implemented FEA model. The comparison show an extremely good match between simulated and measured results, without the need of particular fine-tuning of the model.
A low power programmable gain amplifier with wide dynamic range

The proposed PGA not only consumes low power, as little as 2.16 mW, but has 3 - times a wider BW compared with a conventional VGA. The PGA can obtain as wide a gain range as -29 dB to 33 dB with 1 dB steps. It also has a high IIP3, which was found to be -1 dB.
Dynamic Peach-Koehler self-force, inertia, and radiation damping of a regularized dislocation

The elastodynamic Peach-Koehler force is computed for a fully-regularized straight dislocation with isotropic core in continuum isotropic elastic elasticity, in compact forms involving partial mass or impulsion functions relative to shear and compressional waves. The force accounts for both dynamic radiation damping and inertia. The expressions are valid indifferently for subsonic or supersonic velocities. Results are compared with the case of a flat-core dislocation of the Peierls-Eshelby type, for a motion of jump from rest to constant velocity. In the steady-state limit, the Lagrangian function relevant to expressing the force in the flat-core case must be replaced by a related but different function for the regularized dislocation. However, by suitably defining the regularizing dislocation width, the steady-state limits of the force for the fully-regularized and flat-core dislocations can be matched exactly.
Capacity consideration for indoor femtocell networks in TV white spaces

The Federal Communications Commission (FCC) took the unprecedented step to approve the usage of TV white spaces, i.e., locally vacant TV channels, in 2012. This TV spectrum will present new opportunities for wireless access technologies and applications. The utilization of TV spectrum also comes with some technical challenges. One of the most fundamental is that how much capacity can be achieved in TV white spaces network. Prior works focused on capacity consideration for cellular network in outdoor scenario leaving important femtocell network in indoor scenario largely open for investigation. In this paper, we explore the capacity for femtocell network by developing a TV white spaces reuse and power allocation scheme. The overall objective is to maximize the capacity achieved by a femtocell network while keeping the interference to the primary receiver and macro receiver at an acceptable level. Simulation results show that due to the signal attenuation by the building structure, there exists considerable TV white spaces for potential usage. This result is interesting because we can improve the capacity of femtocell network by using the TV channels.
Electronic Surveillance For Catheter-Associated Urinary Tract Infection Using Natural Language Processing

Catheter-associated urinary tract infection (CAUTI) is a common and costly healthcare-associated infection, yet measuring it accurately is challenging and resource-intensive. Electronic surveillance promises to make this task more objective and efficient in an era of new financial and regulatory imperatives, but previous surveillance approaches have used a simplified version of the definition. We applied a complete definition, including subjective elements identified through natural language processing of clinical notes. Through examination of documentation practices, we defined a set of rules that identified positively and negatively asserted symptoms of CAUTI. Our algorithm was developed on a training set of 1421 catheterizedpatients and prospectively validated on 1567 catheterizedpatients. Compared to gold standard chart review, our tool had a sensitivity of 97.1%, specificity of 94.5% PPV of 66.7% and NPV of 99.6% for identifying CAUTI. We discuss sources of error and suggestions for more computable future definitions.
Infrastructure to support ultra high throughput biodosimetry screening after a radiological event

Purpose: After a large-scale radiological event, there will be a pressing need to assess, within a few days, the radiation doses received by tens or hundreds of thousands of individuals. This is for triage, to prevent treatment locations from being overwhelmed, in what is sure to be a resource limited scenario, as well as to facilitate dose-dependent treatment decisions. In addition there are psycho-social considerations, in that active reassurance of minimal exposure is a potentially effective antidote to mass panic, as well as long-term considerations, to facilitate later studies of cancer and other long-term disease risks. Materials and methods: As described elsewhere in this issue, we are developing a Rapid Automated Biodosimetry Tool (RABiT). The RABiT allows high throughput analysis of thousands of blood samples per day, providing a dose estimate that can be used to support clinical triage and treatment decisions. Results: Development of the RABiT has motivated us to consider the logistics of incorporating such a system into the existing emergency response scenarios of a large metropolitan area. We present here a view of how one or more centralized biodosimetry readout devices might be incorporated into an infrastructure in which fingerstick blood samples are taken at many distributed locations within an affected city or region and transported to centralized locations. Conclusions: High throughput biodosimetry systems offer the opportunity to perform biodosimetric assessments on a large number of persons. As such systems reach a high level of maturity, emergency response scenarios will need to be tweaked to make use of these powerful tools. This can be done relatively easily within the framework of current scenarios.
Entecavir: a potent new antiviral drug for hepatitis B

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus. In vitro this compound has proven to be far more effective than other nucleoside analogues. In animal models, an impressive reduction of serum viral DNA has been observed with covalently closed circular DNA and hepatitis B viral core antigen negativity in liver biopsy specimens. In clinical studies, entecavir revealed excellent suppression of hepatitis B virus replication without significant side effects or evidence of mitochondrial toxicity. Until now, no entecavir-resistant viral mutants have been described. Prolonged therapy as well as prophylactic therapy, for example, in liver transplant recipients, is feasible and not limited by breakthrough infections. Data on entecavir therapy for treatment of nucleoside-naive, wild-type hepatitis B virus is being generated in Phase III clinical trials worldwide for both hepatitis B envelope antigen-positive and -negative subpopulations, as well as in lamivudine-resistant patients. Based on mechanism and potency of interferon and entecavir, clinical trials with combination therapy are eagerly awaited.
Performance evaluation of a new MAC protocol for WDM metropolitan access ring networks

This article considers a WDM slotted‐ring network architecture. A slotted MAC protocol was designed to be used in a metropolitan environment. The results of a discrete event simulation are presented. Assuming that a maximum load threshold is not exceeded, fairness between access nodes is achieved by introducing a very simple mechanism. Excellent queuing delay and packet dropping probability results are obtained. Future developments are presented as they are expected to improve the efficiency and introduce QoS capabilities and congestion avoidance mechanisms. Copyright © 2001 John Wiley & Sons, Ltd.
Epidemiología de las lesiones en el fútbol profesional español en la temporada 2008-2009

El futbol es un deporte con una elevada incidencia de lesiones, tanto durante su practica en entrenamiento como en competicion. Por ello, en este estudio nos proponemos analizar esta incidencia en funcion de diversas variables, como la sesion de entrenamiento o competicion, localizacion de la lesion, tipologia, severidad o mecanismo de produccion de las mismas, asi como la demarcacion del jugador y el momento en el que se producen. Material y metodos: Este estudio lo clasificamos como descriptivo, epidemiologico y dentro de estos como serie de casos clinicos. En el estudio participaron 27 equipos profesionales del futbol espanol (16 equipos de primera division y 11 de segunda division) con un total de 728 jugadores. Los datos para realizar este estudio se extrajeron de la temporada 2008-2009. Resultados: Los resultados senalan que de un total de 244.835 horas se produce un total de 2184 lesiones, lo que supuso una incidencia de lesion de 8,9 por cada 1000 horas de exposicion. Si diferenciamos en funcion de la sesion en la que se produjo, tenemos una mayor incidencia con 40,2 lesiones cada 1000 horas en competicion frente a entrenamiento con 6,0 lesiones, lo que supone un promedio de 80,9 lesiones por equipos y temporada. El 61,7% de las lesiones (n=1348) fueron registradas en entrenamiento, mientras que el 38,3% (n=836) se registro en competicion. Por localizacion, la lesion mas comun fue el muslo posterior (16,3% de todas las lesiones). El 49,1% de las lesiones fueron de tipologia muscular (sobrecarga, contractura o rotura). Las lesiones graves tuvieron una incidencia de 0,8 les/1000h, ademas destaco que el 3,0% de las lesiones registradas (n=65) requirieron cirugia. Conclusiones: El futbol tiene una elevada incidencia de lesiones, siendo estas mayores durante la competicion. Encontramos una elevada frecuencia de lesion de tipologia muscular y ligamentosa, lo que nos hace sugerir la necesidad de integrar programas preventivos con el objetivo de disminuirla.