Miracle-dz/UniFAR-FTUs huggingface dataset:
A possible origin of [M2 nH 1 mX] (m2n)1 ions (X 5 alkali metal ions) in electrospray mass spectrometry of peptides

The [M 2 nH 1 mX] (m2n)1 (X 5 alkali metal ion) are common ions in the mass spectrum of a peptide that is electrosprayed in the presence of an alkali metal salt or hydroxide. The feasibility of forming [M 2 nH 1 mX] (m2n)1 ions in the gas phase including those in the lens region of the mass spectrometer via ion–molecule reactions and/or reactions between components of collisionally activated adducts was investigated. The Li 1 ion was selected for examination since its salts are computationally the least expensive among alkali metal salts. The lithium ion affinities of the [M 2 H] ions of N-methylacetamide, acetic acid, and 1-propanamine were calculated by means of density functional theory (DFT) at various levels of theory, including B3LYP/6-3111G(d, p). These three compounds were selected as representatives of relevant functional groups on a peptide. The calculated lithium ion affinities, together with evaluated thermochemical data, were used to calculate the enthalpies of reactions between the model compounds and LiOH, LiCl, and Li(H 2O) 1 that might lead to the formation of [M 2 nH 1 mX] . A number of these reactions were found to be exothermic or slightly endothermic (DH8 , 120 kcal/mol). DFT calculations on the energetics of a model reaction revealed a relatively flat potential energy hypersurface containing a well of approximately 35 kcal/mol in depth and devoid of significant barriers. These results are used to postulate the formation of [M2 nH 1 mX] (m2n)1 ions in the gas phase in the ion source and/or in the lens region via collisions between an ionic peptide and neutral lithium compounds or collisional activation of lithium–peptide adducts. (Int J Mass Spectrom 192 (1999) 303–317) © 1999 Elsevier Science B.V.
Myo-inositol Catabolism in Salmonella typhimurium : Enzyme Repression Dependent on Growth History of Organism

Biochemical and genetic evidence suggests that NADPH-dependent 2-ketonzyo-inositol reductase and 2-keto-mj~~-inositol dehydratase are associated with mj,o-inositol catabolism in Salruowllri typhiiizurium. When growth of this organism is initiated in salts medium containing citrate and inositol using a citrate-grown inoculuni, ketoinositol reductase is virtually completely repressed. By contrast, when inositol-grown organisms are used as inocuIum, a relatively high level of the enzyme is present in bacteria even after a 20-fold increase in mass in the citrate+ inositol medium. Under these conditions, inositol is used for growth to a significant extent, and citrate is utilized to a lesser extent than when growth is started with citrate-grown organisms. Thus by varying the growth history of the organism, different biochemical phenotypes can be produced without any change in the genotype or in the immediate environmental conditions.
A G-PROTEIN ACTIVATOR, NaF, INDUCES [Ca2+]0-DEPENDENT [Ca2+]C OSCILLATION AND SECRETORY RESPONSE IN RAT PANCREATIC ACINI

Sodium ﬂuoride (NaF), which is known to directly activate various guanine nucleo-tide binding proteins (G-proteins). in the plasma membrane, induced a dose-dependent secretory response in isolated rat pancreatic acini. Effective concentra-tions to induce maximum response and half maximum response (EC50) were l0 mM and 5 mM NaF, respectively. Stimulation with NaF at l5 mM or higher caused smaller response. Typical compound exocytosis was demonstrated by electron microscopy when the pancreas was stimulated with 10 mM NaF, Whereas it was rarely seen when 100 mM NaF was used. Cell damage was not detected by esti-mation of LDH leakage or by electron microscopy in any experimental procedures in the present study. Using a Ca“-sensitive fluorescent dye, fura-2-AM, oscillatory changes in the cytosolic concentration of Ca“, [Ca2+],, were detected by microspec-troﬂuorometry during continuous stimulation with l0 mM NaF. Both NaF-induced secretory response and [Ca2+], oscillation were abolished in [Ca2+],-free environment. The finding that NaF mimics physiological stimulation suggests that activation of G-proteins is an essential physiological step in stimulus-secretion coupling. On these results, we propose a view that the G-protein activation induces [Ca2+], oscillation originated from an inﬂux of extracellular calcium ions and thereby initiates and
APOPTOSIS: ITS PLACE IN EYE DISEASES

kontrollü ve aktif bir mekanizma ile çevre hücrelere zarar vermeden ortadan kaldýrýlma mekanizmasýdýr. Yunanca bir terim olan apoptozis "düþmek, ayrýlmak" anlamýna gelir. Bu aktif hücre ölümü ilk kez Kerr tarafýndan 1972'de tanýmlanmýþtýr (1). Apoptozis embriyogenezin, normal geliþmenin ve bazý hastalýklarýn progresyonunun önemli bir unsurudur. Hücrenin bir bakýma intiharý anlamýna gelir. Yakýn zamanda apoptotik hücre ölümü glokom, retinitis pigmentoza, keratokonus ve retinoblastom gibi bir çok göz hastalýðýnýn patogenezinde tanýmlanmýþtýr.
CORRELATION OF QANADLI SCORE WITH RIGHT VENTRICULAR DYSFUNCTION IN PATIENTS WITH ACUTE PULMONARY EMBOLISM

Background: CT-pulmonary angiography (CTPA) is routinely performed in patients with suspected pulmonary embolism (PE) and a positive relationship between Qanadli score (Q-score) and RVdysfunction enables the clinicians in early diagnosis and management of RV-dysfunction on the basis of this single imaging modality. Objective of the study was to determine the correlation between an established angiographic clot burden score (Qanadli score-QS) and parameters of right ventricular dysfunction (RVD) on CT pulmonary angiography in patients with acute pulmonary embolism. Methods: A Cross-sectional study was carried out for the period of six months from 16 Jun to 15 Dec 2016. Total of forty-six (46) patients of either gender aged 15–70 years with confirmed evidence of PE were recruited. The Q-score and parameters of RV-dysfunction (LV/RV, ratio, SVC diameter, AVdiameter and PA/Ao ratio) were calculated in each patient. Correlation between Q-Score and RV parameters were determined and binary logistic regression analysis was applied to assess Q-score as an independent predictor of RV-dysfunction. Results: Avery strong positive correlation was found between Q-score and LV/RV ratio (r>0.7, p<0.05) collectively and after gender and age based stratification. No significant correlation was found between Q-score and other RV parameters among both genders and age groups (p>0.05 in all cases). No independent factors were found to be significantly related to RV dysfunction after adjustment for other factors (p>0.05). Conclusion: Qanadli score on CT pulmonary angiogram correlates positively with indicators of right ventricular dysfunction of CT angiogram in patients with acute pulmonary embolism and confer a poor prognosis with higher scores.
BIOMARKERS TO TRACK RESPONSE TO SCV-07 RELATED APPLICATIONS

(51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every G01N 33/53 (2006.01) G01N 33/68 (2006.01) kind of national protection available): AE, AG, AL, AM, G01N 33/15 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US20 11/053 139 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP,
uric acid level in chronic kidney disease patients without diabetes ?

Background The fructose overconsumption from high fructose corn syrup may induce numeral direct and indirect undesirable clinical effects like hyperuricemia. Material and methods The aim of the study was to reveal the relationship between fructose consumption — assessed with food frequency questionnaire, blood pressure control and some metabolic disturbances in 72 (age 52.0 ± 2.1; M/ /F 39/33) non-diabetic, chronic kidney disease stage 2–4 patients at out-patient basis. All of them were treated with antihypertensive drugs according to ESH/ESC guidelines. The number of antihypertensive drugs: 3.70 ± 1.41. Results We found significant linear correlation between estimated daily fructose consumption and uric acid level (r = 0.24; p < 0.05) and between the number of antihypertensive drugs and uric acid level (r = 0.30; p < 0.05). No correlation was found between estimated daily fructose consumption and number of antihypertensive drugs. Neither linear nor multiple regression correlations were found between the amount of daily fructose consumption and MAP, SBP, DBP and other factors such as:, BMI, age, sex, GFR, LDL-cholesterol, TG, urine protein excretion. Conclusion The amount of consumed fructose may have the important influence on blood pressure regulation and effectiveness of its therapy in chronic kidney disease stage 2–4 patients. key words: fructose, uric acid, hypertension, chronic kidney disease Arterial Hypertension 2011, vol. 15, no 6, pages 341–346.
vernacular regions in kansas james

Students of American culture are accustomed to seeing the nation divided into regions at many scales. At one level phrases such as New England, the South, and the Middle West are used to define areas of supposed homogeneity, and the regionalization process continues at increasingly finer scales until neighborhoods and similar sized units appear. It is an important, but rarely asked, question whether or not these regional creations of academicians and others bear a resemblance to what one may call vernacular regions, those regions perceived to exist by people actually living in the places under consideration. Vernacular regionalization is part of a larger issue of place awareness or consciousness usually termed "sense of place. " Such awareness has been a traditional concern of humanists and, in recent years, "sense of place" discussions have appeared with increasing frequency in popular publications. The issue has considerable practical importance. Such varied activities as regional planning, business advertising, and political campaigning all could profit from knowledge of how people perceptually organize space. It is ironic that modern America is discovering the importance of place awareness at the time when our increasingly mobile existence makes such a "sense" difficult to achieve. Few people now doubt the advantages, even the necessity, of being in intimate enough contact with a place to establish what Wendell Berry has termed "a continuous harmony" between man and the land. We lack information, however, on the status of our relationship to the land. The study of vernacular regions perhaps can provide insights into this complex issue. The naming of a place and the continued use of that name are indications that its inhabitants are aware of its regional uniqueness. The place has meaning to them, and meaning is a necessary prerequisite for ecological respect. Humanistic scholars from several fields have stressed the impor-
EQUATION MODELING PARTIAL LEAST SQUARES

Abstrak—Bagi PT Mina Wisata Islami penelitian tentang analisis kepuasan pelanggan dan loyalitas menjadi sangat diperlukan, untuk mengetahui seberapa besar pengaruh kepuasan pelanggan, loyalitas, dan beberapa variabel lain yang memengaruhinya selama menggunakan jasa Mina, hasilnya dapat digunakan sebagai referensi evaluasi kinerja perusahaan. Pada penelitian ini akan dibangun sebuah model persamaan yang dapat digunakan untuk mengetahui pengaruh disetiap variabel laten/construct. Variabel laten yang digunakan adalah promosi (Z, sebagai variabel moderator), image perusahaan (X), harapan pelanggan (Y1), komplain (Y2), kepuasan (Y3), dan loyalitas (Y4). Metode analisis yang dipakai adalah Structural Equation Modeling Partial Least Squares (SEM PLS) karena data (sampel) yang akan dianalisis sedikit (n=76). Metode pengumpulan datanya diperoleh dengan cara survey di 8 keberangkatan umroh dan teknik pengambilan sampel menggunakan metode random sampling. Hasil analisisnya adalah terbentuk 9 hubungan antar variabel laten dan terbentuk 4 model persamaan. Dari 9 hubungan antar variabel laten, semua menunjukkan pengaruh yang signifikan dengan pengaruh terbesar diberikan oleh interaksi image dan promosi terhadap harapan pelanggan (1.099), sedangkan pengaruh terkecil diberikan oleh komplain terhadap loyalitas (-0.035). Dari 4 model persamaan, semua telah fits (cocok) dengan statistical power 80%, terdapat 2 model yang mempunyai hubungan kuat (model dengan Y1 dan Y4 sebagai respon) dan 2 model yang mempunyai hubungan lemah (model dengan Y2 dan Y3 sebagai respon). Kata Kunci—SEM PLS, Construct, Variabel Moderator, PT Mina Wisata Islami, Kepuasan Pelanggan, Loyalitas, Umroh
Stem Cell Technology

Stem cells therapy used for treating a range of diseases that are not curable by current therapies is an innovative approach. Stem cells are undifferentiated cells that are found in adult’s tissues and embryo. They are found in multicellular organisms and divide mitotically to selfrenew and can differentiate into different types of cells in appropriate conditions for specific functions. For every organ and tissue in the body, stem cells are served as foundation [1]. There are many different types of stem cells that are formed at different times in our lives and come from different parts in the body. Embryonic stem cells and adult stem cells are two main types of cells that are found in body. Embryonic stem cells are formed from the inner cell mass of blastocysts, and adult stem cells are isolated from various tissues [2]. There are several different sources of stem cell such as embryonic stem cells, tissue-specific stem cells, mesenchymal stem cells, induced pluripotent stem cells, amnoitic stem cells.
Thermal quenches in the stochastic Gross-Pitaevskii equation: morphology of the vortex network

We study the evolution of 3d weakly interacting bosons at fin i e chemical potential with the stochastic Gross-Pitaevskii equation. We fully character ise the vortex network in an out of equilibrium. At high temperature the filament statistics are the ones of full y-packed loop models. The vortex tangle undergoes a geometric percolation transition within the thermodynam ically ordered phase. After infinitely fast quenches across the thermodynamic critical point deep into the order e phase, we identify a first approach towards the critical percolation state, a later coarsening process tha t does not alter the fractal properties of the long vortex loops, and a final approach to equilibrium. Our results are al so relevant to the statistics of linear defects in type II superconductors, magnetic materials and cosmologi cal models. Three dimensional complex field theories with continuous symmetry breaking are used to describe phase transitions in a host of physical systems including superfluid He [1–3], type II superconductors [3, 4], nematic liquid crystals [5], mag netic materials [6], weakly interacting bosons [7], and the early universe [8, 10]. Such phase transitions lead to the formation o f topological defects. In recent years, an impressive theore tical, numerical and experimental effort has been devoted to the measurement of the density of defects after slow quenche s through second order phase transitions [9]. However, very l ittle is known about the size distribution, geometric properties and spatial organisation of the defects inherited from fast and slow quenches. Such questions have been addressed in spin models , and mostly in two dimensions [11,12]. Of particular interest are linear defects, be them vortices , disclinations, or cosmic strings supported by 3d field theories with global U(1) symmetry that capture, in different limits , the systems mentioned in the first paragraph. In this Letter we study the dynamics engendered by the stochastic GrossPitaevskii equation for weakly interacting bosons [13] fro m the point of view of the vortex tangle. We show that the number density of vortex lengths is the one of fully packed models at highT and we fully characterise its time-dependence after sudden quenches. (Relativistic or underdamped extensions yield similar results apart from short-time differences [14].) The stochastic dynamics of the space-time dependent complex scalar fieldψ(x, t) are ruled by the Langevin equation (2iμ− γL)ψ̇ = −∇ψ + g(|ψ| − ρ)ψ − √
Laura Lampio – Sleep in Climacteric: Associative and Predictive Factors

Laura Lampio – Sleep in Climacteric: Associative and Predictive Factors University of Turku, Faculty of Medicine, Department of Obstetrics and Gynaecology, Department of Pulmonary Diseases and Clinical Allergology, Doctoral Programme in Clinical Research, Sleep Research Centre Annales Universitatis Turkuensis, Medica-Odontologica, 2017 Sleep disturbances are common among climacteric women. However, results from polysomnography studies assessing sleep architecture are contradictory, and there is a lack of prospective polysomnography studies in menopausal women. Causal relationships between menopausal hormonal changes, vasomotor symptoms, aging, and other midlife factors remain to be answered. This study aimed to characterize subjective sleep disturbances with cross-sectional design between premenopausal and postmenopausal women, and prospectively. Sleep architecture was measured prospectively in menopausal transition. The aim was to understand associations of sleep with menopausal hormonal changes, aging, other menopausal symptoms, and work. Furthermore, possible premenopausal health-related predictors for sleep disturbances during menopausal transition were examined. The study was conducted in 177 Finnish midlife women, recruited via newspaper announcements. Sleep disturbances after menopause were characterized primarily by insomnia symptoms, but also by symptoms suggesting sleep-disordered breathing. Regarding sleep architecture, aging was associated with more fragmented sleep, lower sleep efficiency, and shorter sleep duration. Increasing follicle stimulating hormone concentration, indicating transition through menopause, was associated with more slow wave sleep. Workdays and vasomotor symptoms were associated with perceived sleep disturbances in postmenopausal women. Predictors for sleep disturbances in menopausal transition were identified in premenopause, such as depressive symptoms, personal crises, and poor perceived health. Despite poorer subjective sleep quality after menopause, aging seems to be responsible for deteriorated sleep architecture. However, sleep in menopausal women may be more vulnerable to external factors. These data emphasize that not all menopausal sleep disturbances result from vasomotor symptoms, and premenopausal predictors for sleep disturbances are identifiable. Evaluation of sleep and risk factors, and timely interventions, should be provided for midlife women.
Tropheryma whipplei endocarditis in Spain ases

Tropherymawhipplei endocarditis is an uncommon condition with very few series and<90 cases reported in the literature. The aim of the study was to analyze the epidemiological, clinical, and outcome characteristics of 17 cases of T. whipplei endocarditis recruited in our country from a multicentric cohort from 25 Spanish hospitals from the Spanish Collaboration on Endocarditis—Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España. From a total of 3165 cases included in the cohort, 14.2%were diagnosed of blood culture negative endocarditis (BCNE) and 3.5% of these had T. whipplei endocarditis. This condition was more frequent in men. The average age was 60.3 years. Previous cardiac condition was present in 35.3% of the cases. The main clinical manifestation was cardiac failure (76.5%) while fever was only present in the 35.3%. Ecocardiography showed vegetations in 64.7% of patients. Surgery was performed in all but 1 cases and it allowed the diagnosis when molecular assays were performed. A broad range rRNA 16S polymerase chain reaction was used for first instance in all laboratories and different specific targets for T. whipplei were employed for confirmation. A concomitant Whipple disease was diagnosed in 11.9% of patients. All patients received specific antimicrobial treatment for at least 1 year, with no relapse and complete recovery. T. whipplei endocarditis is an uncommon condition with an atypical presentation that must be considered in the diagnosis of BCNE. The prognosis is very good when an appropriate surgical management and antimicrobial-specific treatment is given. Abbreviations:BCNE = blood culture negative endocarditis, BID = “bis in die” (twice a day), CSF = cerebrospinal fluid, GAMES = grupo de apoyo al manejo de la endocarditis infecciosa en España, IE= infectious endocarditis, IHC= immunohistochemistry, PAS= periodic acid-Schiff, SXT = trimethoprim-sulfamethoxazole, TOE = transesophageal echocardiography, TTE = transthoracic echocardiography, WD = Whipple disease.
New Treatment Strategies for Dengue and other Flaviviral Diseases

Chair's introduction (Charles Rice). Dengue/dengue hemorrhagic fever: history and current status (Duane J. Gubler). Discussion. Molecular biology of flaviviruses (Eva Harris, Katherine L. Holden, Dianna Edgil, Charlotta Polacek and Karen Clyde). Discussion. Development of novel antivirals against flaviviruses (Chinmay G. Patkar and Richard J. Kuhn). Discussion. Entry functions and antigenic structure of flavivirus envelope proteins Karin Stiasny, Stefan Kiermayr and Franz X. Heinz). Discussion. General discussion I. Multiple enzyme activities of flavivirus proteins (R. Padmanabhan, N. Mueller, E. Reichert, C. Yon, T. Teramoto, Y. Kono, R. Takhampunya, S. Ubol, N. Pattabiraman, B. Falgout, V. K. Ganesh and K. Murthy). Discussion. Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain (Ting Xu, Aruna Sampath, Alex Chao, Daying Wen, Max Nanao, Dahai Luo, Patrick Chene, Subhash G. Vasudevan and Julien Lescar). Discussion. Finding new medicines for flaviviral targets (Thomas H. Keller, Yen Liang Chen, John E. Knox, Siew Pheng Lim, Ngai Ling Ma, Sejal J. Patel, Aruna Sampath, Qing Yin Wang, Zheng Yin and Subhash G. Vasudevan). Discussion. Structural and functional analysis of dengue virus RNA (Diego Alvarez, Maria F. Lodeiro, Claudia Filomatori, Silvana Fucito, Juan Mondotte and Andrea Gamarnik). Discussion. Organization of flaviviral replicase proteins in virus induced membranes: a role for NS1' in Japanese encephalitis virus RNA synthesis (Vijaya Satchidanandam, Pradeep Devappa Uchil and Priti Kumar). Discussion. CRM1 dependent nuclear export of dengue virus type-2 NS5 (Melinda J. Pryor, Stephen M. Rawlinson, Peter J. Wright and David A. Jans). Discussion. T cell responses and dengue haemorrhagic fever (Gavin Screaton and Juthathip Mongkolsapaya). Discussion. The evolutionary biology of dengue virus (Edward C. Holmes). Discussion. Developing vaccines against flavivirus diseases: past success, present hopes and future challenges (John R. Stephenson). Discussion. A genomics approach to understanding host response during dengue infection (Martin L. Hibberd, Ling Ling, Thomas Tolfvenstam, Wayne Mitchell, Chris Wong, Vladimir A. Kuznetsov, Joshy George, Swee-Hoe Ong, Yijun Ruan, Chia L Wei, Feng Gu, Joshua Fink, Andy Yip, Wei Liu, Mark Schreiber and Subhash G. Vasudevan). Discussion. Mouse and hamsters models rodent models for the study of therapy against flavivirus infections (Nathalie Charlier, Pieter Leyssen, Erik De Clercq and Johan Neyts). Discussion. Secretion of flaviviral non-structural protein NS1: from diagnosis to pathogenesis (S. Alcon-LePoder, P. Sivard, M.-T. Drouet, A. Talarmin, C. Rice and M. Flamand). Discussion. Final discussion. Index of contributors. Subject index.