Cyclophosphamide and ifosfamide: mechanisms of cytotoxic action and consequences for normal bladder function.

s as a result of this thesis Kylie Mills, Luke Grundy, Roselyn Rose‘Meyer, Catherine McDermott, Russ Chess-Williams. (2014) Bladder sensory nerve activity is enhanced by the cytotoxic drugs cyclophosphamide and ifosfamide. Proc. ASCEPT Annual Meeting, Melbourne 2014. Mills, K. Chess-Williams, R. McDermott, C. (2014) Can N-acetylcysteine or vitamine-C protect human bladder urothelial cells from acrolein toxicity? World Cancer Congress, Melbourne 2014. Published in Asia-Pacific Journal of Clinical Oncology, Special Issue: 2014 World Congress Abstracts v.10 S9 pp235 (No. 1154). Avilable online at: http://onlinelibrary.wiley. com/doi/10.1111/ajco.12332/epdf Mills, K. Grundy, L. Rose‘Meyer, R. McDermott, C. Chess-Williams, R. (2014) Cyclophosphamide and ifosfamide enhancement of bladder sensory nerve activity. Clinical Oncology Society of Australia, Melbourne 2014. Published in Asia-Pacific Journal of Clinical Oncology, Special Issue: COSA's 41st Annual Scientific Meeting v.10 S8 pp134 (No. 226). Avilable online at: http://onlinelibrary.wiley. com/doi/10.1111/ajco.12305/epdf Mills, K. McDermott, C. Chess-Williams, W. (2013) Chloroacetaldehyde, and not acrolein, is the more uro-toxic metabolite of cyclophosphamide and isofosfamide in vitro. Proc. 43 rd Annual Meeting of the International Continence Society, Barcelona 2013. Available online at: http://www.ics. org/Abstracts/Publish/180/000146.pdf Mills, K. , Chess-Williams, R. , McDermott, C. (2013) Chloroacetaldehyde, not just acrolein, may be involved in the uro-toxicity of cyclophosphamide and ifosfamide. Gold Coast Health and Medical Research Conference Gold Coast 2013 Kylie A Mills, Russ Chess-Williams, Catherine McDermott. (2013) The protective effect of N-acetylcysteine and Vitamin C on acrolein toxicity in human urothelial cells. 5 th National Symposium on Advances in Gastrointestinal & Urogenital Research, Melbourne 2013 Chess-Williams R, Mills K, McDermott C, (2012) Acrolein, a metabolite of cyclophosphamide enhances basal ATP release and reactive oxygen species formation in cultured human urothelial cells. Proc. 42 nd Annual Meeting of the International Continence Society, Beijing 2012. Available online at: http://www.ics. org/2012/programme/search Kylie A Mills, Catherine McDermott, Russ Chess-Williams (2012) Effects of acrolein, a metabolite of Cyclophosphamide and Ifosfamide, on cultured human urothelial cells. Proc. ASCEPT Annual Meeting, Sydney 2012. Available online at: http://www.ascept-apsa.com/wpcontent/uploads/2012/07/ASCEPT-APSA-Poster-Abstracts-570-644.pdf Kylie A Mills, Catherine McDermott, Russ Chess-Williams. (2012) Urinary metabolites acrolein and chloroacetaldehyde alter urothelial cell viability, ROS formation and ATP release. 4 th National Symposium on Advances in Gastrointestinal & Urogenital Research, Sydney 2012 Kylie A Mills, Stanley Kang, Catherine McDermott, Russ Chess-Williams. (2012) A comparison of ATP and ACh release by the human urothelial cell lines RT4 and T24. 4 th National Symposium on Advances in Gastrointestinal & Urogenital Research, Sydney 2012.