Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation

Peptide:N-glycanase (PNGase) cleaves oligosaccharide chains from glycopeptides and glycoproteins. Recently the deduced amino acid sequence of a cytoplasmic PNGase has been identified in various eukaryotes ranging from yeast to mammals, suggesting that deglycosylation may play a central role in some catabolic process. Several lines of evidence indicate that the cytoplasmic enzyme is involved in the quality control system for newly synthesized glycoproteins. Two-hybrid library screening by using mouse PNGase as the target yielded several PNGase-interacting proteins that previously had been implicated in proteasome-dependent protein degradation: mHR23B, ubiquitin, a regulatory subunit of the 19S proteasome, as well as a protein containing an ubiquitin regulatory motif (UBX) and an ubiquitin-associated motif (UBA). These findings by using the two-hybrid system were further confirmed either by in vitro binding assays or size fractionation assays. These results suggest that PNGase may be required for efficient proteasome-mediated degradation of misfolded glycoproteins in mammalian cells.
PENGUJIAN TERHADAP KUALITAS PENGUNGKAPAN CSR DI INDONESIA

Penelitian ini bertujuan untuk mengidentifikasi kualitas pengungkapan tanggung jawab sosial pada laporan keberlanjutan perusahaan yang terdaftar di BEI selama periode 2012-2014. Pengungkapan yang dilakukan oleh perusahaan di setiap industri berbeda-beda, oleh karena itu penelitian ini juga menganalisis secara sub sampel industri agar dapat mengetahui kualitas informasi perusahaan di masing-masing industri. Penelitian ini menggunakan metode analisis konten. Hasil penelitian menunjukkan bahwa informasi yang diungkapkan lebih didominasi oleh informasi yang bersifat kuantitatif. Artinya, perusahaan bukan hanya menyajikan informasi tanggung jawab sosial secara narasi saja, namun juga menyertakan data numeriknya seperti dalam mata uang, bobot, volume, ukuran, dan lain sebagainya. Hasil penelitian juga menunjukkan bahwa meskipun sebagian besar sampel menggunakan GRI sebagai acuan pelaporan tanggung jawab sosial perusahaan, namun informasi yang disajikan belum mencakup keseluruhan indikator GRI sehingga kebutuhan stakeholder atas informasi tanggung jawab sosial belum dapat terpenuhi dengan maksimal. Namun demikian, peningkatan tren pengungkapan mengindikasikan adanya langkah perbaikan terhadap kualitas informasi pengungkapan tanggung jawab sosial perusahaan. Meningkatnya perusahaan dalam menerbitkan laporan keberlanjutan menunjukkan bahwa semakin tingginya minat perusahaan di Indonesia mengenai isu sosial dan lingkungan, khususnya pada perusahaan yang termasuk ke dalam industri high profile.
Gastrointestinal symptoms in Parkinson's disease

We have investigated the prevalence of gastrointestinal (GI) symptoms in 98 individuals with Parkinson's disease (PD) and in a control group of 50. Seventy‐nine of those with PD were being treated with dopaminergic medications and 19 were untreated. Those symptoms occurring more frequently in PD patients than in controls included abnormal salivation, dysphagia, nausea, constipation, and defecatory dysfunction. Except for defecatory dysfunction, symptoms did not correlate with treatment but instead correlated with disease severity. This suggests that the GI symptoms of PD reflect direct involvement in the GI tract by the primary disease process.
E‐learning in the corporate university

Purpose – To explore the development of e‐learning within the context of corporate universities with the aim of informing the debate on e‐learning and establishing key areas of concern for emerging corporate universities.Design/methodology/approach – Three case reviews of large leading edge organizations in different sectors.Findings – Whilst e‐learning has potential, its success is significantly limited by context which influences the degree of sophistication and integration of e‐learning and its ability to contribute to the corporate university learning processes and outcomes.Research limitations/implications – Further research is required on both the learner experience and in the wider evaluation of learning outcomes beyond simple statistical evaluation of participation.Practical implications – Key areas of difficulty are identified as: the focus on generic e‐learning solutions; the barrier imposed by the base technology level of the organization; the overriding concern for ROI at the expense of learne.
Analysis of multipath acoustic field variability and coherence in the finale of broadband basin-scale transmissions in the North Pacific Ocean

The statistics of low‐frequency, long‐range acoustic transmissions in the North Pacific Ocean are presented. Broadband signals at center frequencies of 28, 75, and 84 Hz are analyzed at propagation ranges of 3252 to 5171 km, and transmissions were received on 700‐ and 1400‐m‐long vertical receiver arrays with 35‐m hydrophone spacing. The analysis focuses on the energetic ‘‘finale’’ region of the broadband timefront arrival pattern where a multipath interference pattern exists. Two‐dimensional (depth and time) phase unwrapping is employed to study separately the complex field phase and intensity.
Cogging Torque Minimization of SMC PM Transverse Flux Machines Using Shifted and Unequal-Width Stator Teeth

This paper proposes a method to minimize the cogging torque of a permanent-magnet transverse flux machine (PMTFM) with soft-magnetic-composite cores, using the shifted stator disks and unequal stator teeth pairing. Fourier analysis is performed to find the major cogging torque component so as to reduce it by shifting the stator disks. The unequal stator teeth pairing technique that is traditionally used in the radial and axial flux machines is employed to reduce the cogging torque of PMTFMs in this paper. Three different configurations are studied. The cogging torque and the electromagnetic torque are calculated by the three-dimensional finite-element method and verified by the experiment results.
The clinical evaluation of platelet-rich plasma on free gingival graft's donor site wound healing

ABSTRACT Objective: It has been proved that platelet-rich plasma (PRP) can promote wound healing. In this way, PRP can be advantageous in periodontal plastic surgeries, free gingival graft (FGG) being one such surgery. Materials and Methods: In this randomized split-mouth controlled trial, 10 patients who needed bilateral FGG were selected, and two donor sites were randomly assigned to experience either natural healing or healing-assisted with PRP. The outcome was assessed based on the comparison of the extent of wound closure, Manchester scale, Landry healing scale, visual analog scale, and tissue thickness between the study groups at different time intervals. Statistical Analysis Used: Repeated measurements of analysis of variance and paired t-test were used. Statistical significance was P ≤ 0.05. Results: Significant differences between the study groups and also across different time intervals were seen in all parameters except for the changes in tissue thickness. Conclusion: PRP accelerates the healing process of wounds and reduces the healing time.
Study of Regional Development Based Micro, Small and Medium Enterprises

Law of the Republic of Indonesia No.20/2008 on Micro, Small and Medium Enterprises (SMEs) explain the meaning of the micro, small and medium enterprises. SME is a business activity that is able to expand employment and provide economic services to the wider community and can play a role in the distribution process and improve household incomes, encourage economic growth and play a role in achieving national stability. Moreover, SMEs are one of the main pillars of the national economy should gain major opportunities, support, protection and development of the widest as a manifestation of partisanship that explicitly attempt to group people's economy.
Linear Phase Correction Models for Synchronization: Parameter Identification and Estimation of Parameters

Linear phase correction models for synchronized tapping and their stochastic properties are presented. In the most general form they include a central timer, a motor execution, and a phase correction mechanism that acts on the physical or the perceived asynchrony. A central issue of the article is how to identify and estimate the model parameters from the data. Monte Carlo simulations show serious problems of parameter interdependency.
Feeding layers of different genotypes in organic feed environments

1. Two experiments were carried out to evaluate the suitability of an experimental laying hen genotype (SH) in organic egg production. SH had been selected over 25 generations on a low protein diet (130 g/kg) based on home grown feedstuffs. SH hens were compared with LSL (Experiment 1) and Hyline (Experiment 2) hens. The birds were kept in 12 aviary pens with access to outdoor runs. 2. Four diets, which were different in each experiment, were used. A control diet was compared with diets based on feedstuffs supposed to be able to be grown and produced according to organic standards. The diets differed in the content of sulphur amino acids. 3. There were no significant differences in mortality caused by diets or genotypes but an incidence of cannibalism occurred in one Hyline group fed on the diet with the lowest methionine content. 4. Severe feather pecking of LSL birds occurred and was worst on the low protein diet. In Experiment 2, signs of feather pecking of birds on the low protein diet occurred at the end of the experiment, but there was no difference between the genotypes. There was no significant difference in number of eggs produced between diets. Egg weight was influenced by diets in both experiments and by genotype in Experiment 2. Number of misplaced eggs was higher in SH hens in both experiments. There were few significant diet × genotype interactions. 5. The use of the outdoor area was influenced by diets and genotype in both experiments. 6. In conclusion, diets low in methionine content influenced predominantly plumage condition and egg weight, although production of eggs by number was unaffected. The SH hen adapted well to organic conditions, as did the Hyline genotype.
Nontraumatic injuries in amateur long distance bicyclists

All 132 participants in a 500 mile, 8 day bicycle tour were surveyed by questionnaire to characterize the demographics and bicycling experience of the riders, and to determine the frequency and severity of non traumatic injuries they experienced. Riders who devel oped significant symptoms were interviewed and/or examined. Eighty-six percent of ride participants re sponded to the survey. The average age of the riders was 41.4 years (±11.7 years). They rode an average of 95.8 miles per week on a routine basis, but the majority were new to long distance touring. Most were healthy, but 5% had seri ous cardiovascular disease and bicycled as part of a rehabilitation program. The most common nontraumatic injury was buttocks pain (experienced by 32.8% of riders); four had skin ulceration of the buttocks. Knee problems occurred in 20.7% of riders; patellar pain syndromes and lateral knee complaints were the most common knee prob lems. One cyclist withdrew from the tour because of knee pain. Neck-shoulder pain occurred in 20.4% of the riders. Groin numbness and palmar pain or paresthesias each occurred in approximately 10%. Other less common problems were foot and ankle symptoms and sunburn.
Depression, the Metabolic Syndrome and Cardiovascular Risk

Background: The relationship between depression and the metabolic syndrome is unclear, and whether metabolic syndrome explains the association between depression and cardiovascular disease (CVD) risk is unknown. Methods: We studied 652 women who received coronary angiography as part of the Women's Ischemia Syndrome Evaluation (WISE) study and completed the Beck Depression Inventory (BDI). Women who had both elevated depressive symptoms (BDI ≥10) and a previous diagnosis of depression were considered at highest risk, whereas those with one of the two conditions represented an intermediate group. The metabolic syndrome was defined according to the ATP-III criteria. The main outcome was incidence of adverse CVD events (hospitalizations for myocardial infarction, stroke, congestive heart failure, and CVD-related mortality) over a median follow-up of 5.9 years. Results: After adjusting for demographic factors, lifestyle and functional status, both depression categories were associated with about 60% increased odds for metabolic syndrome compared with no depression (p = .03). The number of metabolic syndrome risk factors increased gradually across the three depression categories (p = .003). During follow-up, 104 women (15.9%) experienced CVD events. In multivariable analysis, women with both elevated symptoms and a previous diagnosis of depression had 2.6 times higher risk of CVD. When metabolic syndrome was added to the model, the risk associated with depression only decreased by 7%, and both depression and metabolic syndrome remained significant predictors of CVD. Conclusions: In women with suspected coronary artery disease, the metabolic syndrome is independently associated with depression but explains only a small portion of the association between depression and incident CVD. BDI = Beck Depression Inventory; CAD = coronary artery disease; CVD = cardiovascular disease; DASI = Duke Activity Status Inventory; HDL = high-density lipoprotein; LDL = low-density lipoprotein; WISE = Women's Ischemia Syndrome Evaluation; NHLBI = National Heart, Lung, and Blood Institute.
The design of EDI controls using case-based reasoning: EDICBR

This paper gives a description of EDICBR (EDI Controls design using Case-Based Reasoning), a case-based reasoning model for generating recommendations of EDI controls. The case base of EDICBR is composed of slots that include environmental and EDI controls. This system makes it possible to propose the EDI controls most needed in certain organizational contexts. This is performed by the following two steps. First, it suggests that the most probable level of controls from the cases be retrieved. Second, it determines the required controls that have the highest performance among the retrieved cases. EDICBR uses past cases to remind EDI auditors of similar cases and provides control recommendations. As a method to evaluate the effectiveness of EDICBR, the predictive power of the system is compared with that of multivariate discriminant analysis (MDA). The results show that the case-based reasoner outperforms MDA in predictive accuracy. © 1998 John Wiley & Sons, Ltd.
Werkvertragsunternehmen: Outsourcing auf dem Betriebsgelände

Wir beobachten aktuell einen Strategiewechsel in Industrieund Dienstleistungsunternehmen: Tätigkeiten und Produktionsschritte, die bislang durch die Stammbeschäftigten des Unternehmens ausgeführt worden sind, werden an ein anderes, zweites Unternehmen vergeben. Dieses zweite Unternehmen wird mit einem Werkvertrag beauftragt und führt die vereinbarten Tätigkeiten mit eigenem Personal, aber an den Maschinen und auf dem Betriebsgelände des ersten, beauftragenden Unternehmens aus. Zielsetzung dieser Konstruktion scheint es zu sein, tarifvertragliche, arbeitsund mitbestimmungsrechtliche Ansprüche der (Stamm-) Beschäftigten des Industrieunternehmens zu umgehen. Solche Werkvertragsunternehmen haben sich nicht nur im Bereich industrieller Produktion etabliert, sondern auch bei privaten und öffentlichen Dienstleistungen, u.a. im Handel und in Krankenhäusern. Was ist das Neue daran? Worin unterscheiden sich diese Werkverträge von Leiharbeit, von „Outsourcing“ und von den Werkverträgen, wie sie schon seit Jahren in der Wirtschaft vereinbart werden? Werkverträge wurden bisher vor allem dann eingesetzt, wenn ein Unternehmen für ein bestimmtes Produkt, ein Gewerk oder eine Leistung eigene Kapazitäten und fachkompetentes Personal nicht vorhalten will. D. h. die Unternehmen kaufen Produkte und Leistungen ein, die sie nur gelegentlich benötigen und deren Erstellung sie nicht zum Kernkompetenzbereich ihres Unternehmens zählen. Beispiele hierfür sind die vielen verschiedenen Gewerke beim Bau und Ausbau von Gebäuden oder Industrieanlagen, Kantinen, IT-Produkte und IT-Service. Dieser Typus der Werkvertragsvergabe wird auch weiterhin praktiziert. Die im Mittelpunkt der folgenden Betrachtung stehenden „neuen“ Werkverträge unterscheiden sich hiervon in dreierlei Hinsicht:
Factors Influencing E-Service Quality in Indian Tourism Industry

The online tourism industry is growing at a fast pace in India. The traditional forms of tourism are being replaced by new form e-tourism. The internet has offered with easy and cost effective solution to people who go for online travel bookings. E-service tourism companies need to understand the customer requirement and meet their expectations by evaluating and improving their website quality. The paper explores the factors of E-service quality in Indian context. The results indicated eleven factors affecting of electronic service quality. The study found that mere online presence was not important but providing excellent e-services on websites was essential to retain customers.
Towards development of self-learning and self-modification spiking neural network as model of brain

In this paper novel architecture of artificial intelligence based on spike neural networks is proposed. This architecture includes some perception, some action modules and control module supervising learning of others. Control module is based on generation and learning to generate basic emotions: positive and negative. These emotions are supervising learning and behavior of whole system.
BetterNet A Decision Support System for Chlorination of Water Distribution Systems

— One of the challenging problems of water supply engineers is to provide safe water at the consumers’ tap. Chlorine is a widely utilized disinfectant in water distribution systems to provide such safety. Utilization of booster stations can be a remedy to keep free residual of chlorine levels within desirable limits and to satisfy acceptable low variability. In this research, a decision support system for chlorination of water distribution systems what we call BetterNet is developed. The system provides an effective tool for the decision makers and improves the quality of the WDS design process. More importantly, it reduces possible unnecessary expenditures due to wrong decisions about boosting station number, location and amount of chlorine to be used. With its tunable parameters and support to different objective functions, user can operate the system and obtain the decision support via easy-to-use graphical user interface.
Fibroblast growth factor 2‐induced angiogenesis in zebrafish: the zebrafish yolk membrane (ZFYM) angiogenesis assay

Angiogenesis plays a key role in tumour growth and metastasis. The teleost zebrafish (Danio rerio) represents a promising alternative model in cancer research. Here, we describe a zebrafish yolk membrane (ZFYM) angiogenesis assays based on the injection of 1–30 ng of human recombinant FGF2 (rFGF2) in the perivitelline space of zebrafish embryos in the proximity of developing subintestinal vein vessels (SIVs) at 48 hrs after fertilization. The rFGF2 induces a rapid and dose‐dependent angiogenic response from the SIV basket, characterized by the ectopic growth of newly formed, alkaline phosphatase‐positive blood vessels. These vessels are formed by proliferating cells that incorporate bromodeoxyuridine and express the endothelial cell markers vegfr2/kdr and fli1. Microangiography shows that rFGF2‐induced vessels are patent and connected to the systemic circulation of the embryo. In keeping with these observations, fli1:EGFP+ cells isolated from transgenic tg(fli1:EGFP)y1 zebrafish embryos express the tyrosine kinase (TK) FGF receptor‐1 (FGFR1) and activate extracellular signal‐regulated kinase signalling when stimulated in vitro by rFGF2. The low molecular weight TK‐FGFR1 inhibitor SU5402 and the high molecular weight FGF2 antagonist long‐pentraxin 3 inhibit the angiogenic activity of rFGF2 when added to fish water or when co‐injected with the growth factor, respectively. Moreover, similar to rFGF2, injection of the zebrafish form of vascular endothelial growth factor‐A (VEGF‐A) induces a significant angiogenic response in the ZFYM assay that is suppressed by the VEGF receptor‐2/KDR TK inhibitor SU5416. The ZFYM assay represents a novel tool for testing the activity of low and high molecular weight inhibitors targeting a defined angiogenic growth factor in zebrafish. The assay may offer significant advantages when compared to other animal models.
Malolactic fermentation by engineered Saccharomyces cerevisiae as compared with engineered Schizosaccharomyces pombe

The ability of yeast strains to perform both alcoholic and malolactic fermentation in winemaking was studied with a view to achieving a better control of malolactic fermentation in enology. The malolactic gene of Lactococcus lactis (mleS) was expressed in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The heterologous protein is expressed at a high level in cell extracts of a S. cerevisiae strain expressing the gene mleS under the control of the alcohol dehydrogenase (ADH1) promoter on a multicopy plasmid. Malolactic enzyme specific activity is three times higher than in L. lactis extracts. Saccharomyces cerevisiae expressing the malolactic enzyme produces significant amounts of l‐lactate during fermentation on glucose‐rich medium in the presence of malic acid. Isotopic filiation was used to demonstrate that 75% of the l‐lactate produced originates from endogenous l‐malate and 25% from exogenous l‐malate. Moreover, although a small amount of exogenous l‐malate was degraded by S. cerevisiae transformed or not by mleS, all the exogenous degraded l‐malate was converted into l‐lactate via a malolactic reaction in the recombinant strain, providing evidence for very efficient competition of malolactic enzyme with the endogenous malic acid pathways. These results indicate that the sole limiting step for S. cerevisiae in achieving malolactic fermentation is in malate transport. This was confirmed using a different model, S. pombe, which efficiently degrades l‐malate. Total malolactic fermentation was obtained in this strain, with most of the l‐malate converted into l‐lactate and CO2. Moreover, l‐malate was used preferentially by the malolactic enzyme in this strain also.
Timing of loading and effect of micromotion on bone-dental implant interface: review of experimental literature.

A significant no-load healing period is the generally accepted prerequisite for osseointegration in dental implantology. The aim of this article was to examine whether this no-load healing period is validated by the experimental literature. In vivo histological data was scrutinized to identify the effect of early loading protocols on the bone-implant interface. Several loading modes were identified. They were categorized into groups according to implant design and the type of prosthetic reconstruction, and by their ability to introduce a distinct magnitude of motion at the interface. Specific histologic responses of early loaded implants (i.e., fibrous repair or osseointegration) were suggested to be directly related to the specific combinations of the above parameters. Early loading per se was not found to be detrimental to osseointegration. Specifically, only excessive micromotion was directly implicated in the formation of fibrous encapsulation. The literature suggests that there is a critical threshold of micromotion above which fibrous encapsulation prevails over osseointegration. This critical level, however, was not zero micromotion as generally interpreted. Instead, the tolerated micromotion threshold was found to lie somewhere between 50 and 150 microns. Suggestions are made for the earliest loading time that achieves osseointegration.