Miracle-dz/UniFAR-FTUs huggingface dataset:
An ovine adenovirus vector lacks transforming ability in cells that are transformed by AD5 E1A/B sequences.

Adenoviruses of the Mastadenovirus and Aviadenovirus genera are able to transform certain cell types and induce tumor formation in susceptible animals. For the mastadenoviruses the E1A/B sequences are largely responsible for these properties but E4 sequences may also be involved. The transforming sequences of the aviadenoviruses, which lack E1A/B and E4 homologues, have not yet been fully identified. The recent proposal for a third genus of adenoviruses, which apparently lack an E1A homologue and have weak E1B homology, prompted an examination of the transforming properties of ovine adenovirus OAV287 (OAV), the prototype member of the new group. When OAV and human adenovirus type 5 (Ad5) were used to infect primary rat embryo cells, transformed foci developed in Ad5- but not in OAV-infected cultures. Similarly, after plasmid transfection, baby rat kidney cells were transformed by Ad5 E1A/B but not by OAV sequences. When CSL503 cells, an ovine cell line that is permissive for OAV, were transfected with Ad5 E1A/B sequences, transformed foci again appeared. However, plasmids or fragments containing complete or partial OAV genome sequences did not detectably transform CSL503 cells under the same conditions. When Ad5 E1A/B sequences were incorporated into the complete OAV genome and transfected, transformed clones were again obtained, showing that the gene dosage and transfection conditions were not limiting for transformation. The provision of Ad5 E1A and OAV sequences in combination marginally increased the number of morphologically altered foci in baby rat kidney cells but failed to induce multilayered focus formation. The data suggest that OAV lacks transforming functions in the cell types examined. Additional information suggesting that OAV may have a fundamentally distinct strategy for replication compared with other Ads is discussed.
Derivations of Structured Objects

We propose a model of derivations for applications in linguistics. The model formalizes derived syntactic objects (DSOs) as objects in some category A and structural changes as morphisms in that category. For each such A , we construct a category D ( A ) of ‘derivations’: sequences of DSOs connected by structural changes. We characterize many important relations between derivations, grammatical rules, DSOs, and grammars in terms of the derivable structures and structural changes, such as isomorphisms and embeddings of derivations and DSOs and strong equivalence of languages. The technology builds on both graph grammars and formal minimalist grammars. We then present better-behaved representably concrete categories ADer whose isomorphisms, substructures, etc. can be reduced to set-theoretic manipulations. We also give translations of existing models from the literature into this form.
New protocols for the extraction of nucleic acids from soil

Sir, The publication by Wang et al. (2009), presenting ‘An improved method to extract RNA from soil with efficient removal of humic acids’, is of great interest. The application of the improved protocol proposed there resulted in the recovery of highly pure RNA from soil samples and increased the amount of extracted RNA tenfold compared to the original method. Therefore, the study may certainly be considered another step towards reproducible results in molecular biological soil analysis. However, an adjustment of the amount of applied Al2(SO4)3, as recommended by Peršoh et al. (2008) to quantitatively remove the humic substances from the analysed soil samples prior to cell lysis, was renounced. The proposed method may therefore be indeed more time-efficient, but may only provide comparable results in an experimental design, in which parallel sub-samples of one and the same soil sample are processed. It has to be considered that all types of nucleic acid extraction protocols, which are based on the separation of humic substances from nucleic acids subsequent to cell disruption, share a common shortcoming. As demonstrated by Crecchio and Stotzky (1998), nucleic acids in aqueous solution irreversibly bind to humic acids. This results in a substantial loss of nucleic acids during such a posterior purification step. Furthermore, the amount of loss correlates with the quantity and depends on the, rarely known, quality of the humic substances in a given soil sample. Therefore, an entire removal of humic substances from soil samples prior to cell disruption is highly recommended for any kind of quantitative molecular biological studies, in which different soil types or horizons are comparatively analysed for their nucleic acid content and composition.
Reproduction of four base magnetic units in the unified standard of VNIIM

The described measurement standard is developed on the basis of modern magnetic measuring techniques to substitute three standards operated earlier at VNIIM. In the unified measuring system the standard reproduces four base units of magnetic quantities, as well as the ratios of these units to the ampere: magnetic flux density (MFD) - T, magnetic flux (MF) -Wb, magnetic moment - Am2 and MFD gradient - T/m. It allows realizing modern calibration system for magnetic measuring and reproducing instruments.
Improving Teaching Does Improve Teachers

The authors comment on the article by Morris and Hiebert in three ways. First, they add thoughts about why improvement efforts often focus on teachers, rather than teaching. Second, they offer evidence from U.S. lesson study research that focus on teaching can improve both students’ learning and teachers’ learning. Finally, they suggest that the instructional products and common assessments advocated by Hiebert and Morris are not sufficient, and that they need to be accompanied by practice-based, collegial learning in which teachers build shared knowledge and commitments for the hard work of improvement. Their research indicates that lesson study focuses on teaching, but improves teachers as well, increasing mathematical knowledge and beliefs that support instructional improvement, as well as improving student learning.
Factors involved in the development of boar taint

Boar taint has been mainly associated with the presence of androstenone and skatole in adipose tissue of entire male pigs. This work was focused on the effects of breed, age, hormonal status, and diet composition on boar taint level. The results showed that skatole levels in entire male pigs varied considerably with age, and the degree as well as the pattern of this variation differs between different breeds. The initial increase in skatole levels might occur at a relatively young age of 8-10 weeks. Later, the levels of skatole decreased and remained low until puberty. As puberty development progressed, skatole levels increased again reaching very high levels in some individuals. The increase in skatole levels followed the increase in levels of testicular steroids. These findings indicate that there is a relationship between the process of sexual development and high skatole levels, and that the increase in the levels of testicular steroids at puberty may affect skatole levels. The decreased activities of the main enzymes controlling skatole metabolism in the liver also contributed to increased skatole levels during this period. No direct relationship between skatole and thyroid hormones and IGF-1 was found. The dietary supplement of raw potato starch or lower weight at slaughter reduced skatole levels in entire male pigs, but did not affect androstenone levels or the activities of cytochrome P4502E1 and cytochrome P4502A6. Raising entire male pigs in mixed pens resulted in increased skatole levels in plasma in pigs of 115 kg live weight fed raw potato starch. Androstenone levels were higher in pigs at 90 kg live weight raised in mixed pens, but not in heavier pigs. A new method to determine free oestrone in porcine adipose tissue was developed and applied to investigate the relationship between boar taint compounds and hormonal status in entire male pigs. Both skatole and androstenone were positively correlated to free oestrone levels. Overall, the results suggest that puberty is a main factor controlling androstenone levels. Skatole levels are regulated by a number of factors, including breed, age, hormonal status and diet.
Improvement of TANOS NAND Flash Performance by the Optimization of a Sealing Layer

We presented an optimization of an interfacial SiO2 sealing layer between the nitride and top dielectric of a TANOS stack showing a strong retention improvement thanks to an increased DeltaEc to Si3N4, that prevents vertical escape of the electrons through the top dielectric. In case of HfAlO top dielectric, it also provides a better program/disturb margin.
Capture of solar wind alpha‐particles by the Martian atmosphere

Integration along He++ test‐particle trajectories in the self‐consistent electromagnetic fields generated by three‐dimensional hybrid simulations of the solar wind/Mars interaction is used to evaluate the removal of solar wind α‐particles due to charge‐exchange processes with neutral species of the Martian exosphere. The total removal rate of solar wind He++ ions, transformed into either singly ionised or neutral helium, is equal to 6.7 × 1023 s−1, which corresponds approximately to 30% of the flux of solar α‐particles through the planetary cross‐section. The deposition rate of helium neutral atoms, created by double electronic capture on exospheric oxygen, impacting the exobase, and penetrating below where it can be trapped, is about 1.5 × 1023 s−1. That means an important contribution of the solar wind source to the helium balance of the Martian atmosphere. The implantation of the solar helium into the Martian atmosphere shows an asymmetry related to the orientation of the motional electric field of the solar wind, −VSW × BIMF.
The effects of surface potential on surface recombination and the performance of silicon solar cells

This paper describes the effect on the short circuit current of varying the surface potential of the illuminated surface of an Interdigitated Back Contact solar cell. The surface potential of the IBC cell is controlled by means of a transparent conducting field plate. The application of a suitable potential to the conducting layer can modulate the surface potential from strong accumulation through depletion to strong inversion. The results of this experiment are explained in terms of the effects of the varying surface potential on surface recombination and the depletion layer recombination, which occurs in the case of an inverted surface. The results of computer calculations are also presented. A comparison of the relative merits of the Front Surface Field cell, the Interdigitated Back Contact cell, and the Tandem cell is made based on the experimental and theoretical results presented.
Laryngeal adenoid cystic carcinoma: case report.

CONTEXT Adenoid cystic carcinomas are malignant tumors that occur in both the major and the minor salivary glands. A laryngeal location is rare because of the paucity of accessory salivary glands in this area. Adenoid cystic carcinomas account for less than 1% of all malignant tumors in the larynx, and only about 120 cases have been reported in the literature. These tumors have a slight female predisposition, and their peak incidence is in the fifth and sixth decades of life. In this article, we describe a case of laryngeal adenoid cystic carcinoma and discuss its clinical characteristics and treatment. CASE REPORT We report on a case of laryngeal adenoid cystic carcinoma in a 55 year-old female patient who presented with dyspnea and hoarseness. Features of the diagnostic and therapeutic evaluation are described and the clinical management of such cases is outlined. The clinical course, definitive treatment strategy and surgical procedure, and also adjuvant treatment with irradiation are discussed. Although the tumor is radiosensitive, it is not radiocurable.
Fast-Varying and Transient Nonlinear Equation for Microstructure Fibers

The transient nonlinear equation that describes the fast varying field in microstructure fibers (photonic crystal fibers) is established. In this equation, the frequency and wavenumber are functions of time. It is solved using two methods (the Volterra series integration and the Laplace transformation) and validated by comparing its simulation results with those of reported experiments and published theories. It is demonstrated that due to the introduction of the functions <inline-formula><tex-math notation="LaTeX">$\omega (t)$</tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$\beta (t)$</tex-math></inline-formula> in the Maxwell's equations, new frequencies are continually induced and amplified by the nonlinear effect (supercontinuum generation). The second-order differential of the field to transmission distance (<inline-formula><tex-math notation="LaTeX">${\partial ^2}A{\rm{/}}\partial {z^2}$</tex-math></inline-formula>) cannot be deleted, and in the resonance condition, this field exhibits a periodic oscillation along <italic>z</italic>. This property can be utilized to interpret the principle of photonic crystal fiber metamaterials.
Is there a Link Between Atherothrombosis and Deep Venous Thrombosis?

ABSTRACT Venous and arterial thromboses have traditionnally been regarded as separate diseases with different causes. Clinical experience shows, that the arterial atherothrombotic disease can be associated with venous thrombotic disease, but there is insufficient evidence to prove and explain the nature of this association.This review focuses on the risk factors associated with both arterial and venous thrombotic events, and recent epidemiological studies have documented an association between these vascular complications.According to the results of recent studies, atherosclerosis and venous thrombosis share common risk factors, including age, obesity, cigarette smoking, and metabolic syndrome.Several studies have demonstrated that subjects with idiopathic venous thrombosis have an increased risk of cardiovascular events compared with subjects with secondary thrombosis or control group. On the other hand, atherosclerosis has the potential to promote the development of thrombotic disorders in the venous system. Based on the results of population studies carried out in the United States, atherosclerosis is unlikely to constitute a risk factor for venous thrombosis. In conclusion, the separate nature of arterial and venous disorders has been challenged. Future studies are needed to clarify the nature of this association, and to evaluate its implications for clinical practice.
Secondary Literacy Across the Curriculum: Challenges and Possibilities

This paper discusses the challenges and possibilities attendant upon successfully implementing literacy across the curriculum initiatives–or school language policies' as they have come to be known–particularly at the secondary or high school level. It provides a theoretical background to these issues, exploring previous academic discussions of school language policies, and highlights key areas of concern as well as opportunity with respect to school implementation of such policies. As such, it provides a necessary conceptual background to the subsequent papers in this special issue, which focus upon the Secondary Schools' Literacy Initiative (SSLI)–a New Zealand funded programme that aims to establish cross-curricular language and literacy policies in secondary schools.
Routinely asking women about domestic violence in health settings

The stigma surrounding domestic violence means that many of those affected are reluctant or do not know how to get help. A systematic review of screening for domestic violence in healthcare settings concluded that although there was insufficient evidence to recommend screening programmes, health services should aim to identify and support women experiencing domestic violence.1 The review highlighted the importance of education and training of clinicians in promoting disclosure of abuse and appropriate responses.1 We argue that a strong case exists for routinely inquiring about partner abuse in many healthcare settings.
User Search Histories Based On Query Relevance Using Incremental Algorithm

Automatically characteristic the query group is useful for variety of various computer program elements and applications, like question suggestions, result ranking, question alterations, sessionization, and cooperative search. In our approach, we have a tendency to transcend approaches that have confidence matter similarity or time thresholds, and that we propose a lot of strong approach that leverages search question logs. Incremental algorithm algorithm is used in the proposed approach to improve the quality of search. Incremental algorithms are radically different from static strategies for the approach they build and use recommendation models.
Diagnostic and molecular implications of specific chromosomal translocations in mesenchymal tumors.

In many tumors of mesenchymal origin specific chromosomal translocations are a consistent finding not restricted to malignant tumors. Often the genes behind those translocations have been identified. Rarely, gene activating per se is sufficient to contribute to or cause tumorigenesis whereas in most cases the two genes of the translocation partners both contribute to the formation of a newly arisen fusion gene, thus enabling the detection of resulting chimeric transcripts by highly sensitive techniques. Genes participating in translocations may be affected in more than one tumor entity, such as e.g. HMGIC in a variety of benign mesenchymal tumors and EWS in a couple of malignant mesenchymal tumors. Certainly, the identification and molecular characterization of specific chromosomal translocations will not only allow for important insights highlighting the process of tumorigenesis but offer also promising new tools to obtain more refined data of diagnostic as well as of prognostic importance.
Univariate Modelling of Electricity Consumption in South Africa: Neural Networks and Neuro-fuzzy Systems

This paper presents an experiment that consists of constructing neural networks and neuro-fuzzy models with historical electricity consumption time series data to create models that can be used to forecast consumption in the future. The data was sampled on a monthly basis from January 1985 to December 2011. A multilayer perceptron neural network with back propagation and neuro-fuzzy modelling technique which combines Takagi-Sugeno fuzzy models and neural networks were used to create the models. Different input sizes were used to construct 10 different one step ahead forecasting models for each technique. The results of the two techniques were compared and the results show that neuro-fuzzy models outperformed the neural network models in terms of accuracy.
60% Cycle time acceleration, 55% energy reduction, 32Kbit SRAM by auto-selective boost (ASB) scheme for slow memory cells in random variations

An auto selective boost (ASB) scheme for slow SRAM memory cells in random variations has been proposed. ASB shortens the cycle time and decreases the average BL amplitude, which reduces both dynamic and leakage energy dissipation. The cycle time of SRAM is reduced by 60% at 0.5V using the proposed ASB scheme. By combining the ASB with a BL amplitude limiter (BAL), the energy dissipation is reduced by 55%. A 32Kbit SRAM with the ASB and BAL schemes has been fabricated by 40nm CMOS technology.
Pronounced Accumulation of Metoprolol in Ischemic Myocardium After Coronary Venous Retroinfusion

The myocardial availability of the β1-selective blocker metoprolol was compared following standard intravenous (i.v.) administration and after coronary venous retroinfusion. Thirteen open-chest farm pigs were subjected to 90-min occlusion of the left anterior descending coronary artery. In six of these pigs, metoprolol was ad-ministered as an i.v. injection while 7 pigs received the drug retrogradely into the coronary vein. The time of ad-ministration was 5 min. In both groups, metoprolol was administered after 30 min of coronary artery occlusion. Metoprolol did not influence heart rate (HR) or blood pressure (BP) whether administered i.v. or into the coronary vein. At the end of administration, plasma metoprolol was significantly higher when administered i.v. (2,955 ± 543 nmol/L) than after coronary venous infusion (1,213 ± 464 nmol/L; p < 0.05). At 30 and 60 min after injection, plasma metoprolol did not differ significantly between the two groups. Myocardial tissue concentration of metoprolol in nonischemic myocardium was 480 pmol/g for both groups and similar in the subendocardial, midmyocardial, and subepicardial layers of the myocardium. After i.v. administration, myocardial Metoprolol concentration in the ischemic zone was less than that in the nonischemic zone, averaging 150–300 pmol/g tissue. In contrast, coronary venous retroinfusion of metoprolol resulted in a substantial accumulation of the drug in the ischemic zone, as exemplified by a subendocardial concentration of 2,002 ± 689; a midmyocardial concentration of 26,643 ± 8,813 and a subepicardial concentration of 98,571 ± 58,930 pmol/g, respectively (mean ± SE). Coronary venous retroinfusion of metoprolol resulted in a pronounced accumulation of drug in the ischemic myocardium. The transmyocardial concentration gradient was significant, with the highest levels in the subepicardial layers and the lowest in the subendocardial layers. These high concentrations of metoprolol were obtained without any adverse hemodynamic effects.
Homocysteine enhances TIMP-1 expression and cell proliferation associated with NADH oxidase in rat mesangial cells.

BACKGROUND Recent studies in our laboratory demonstrated that chronic hyperhomocysteinemia (hHcys) induced glomerular sclerosis. The mechanism mediating hHcys-induced glomerular damage remains unknown. The present study was designed to test a hypothesis that homocysteine (Hcys) increases the production by nicotinamide adenine dinucleotide (NADH) oxidase and thereby stimulates the formation of tissue inhibitor of metalloproteinase (TIMP-1) in rat mesangial cells, consequently leads to glomerulosclerosis. METHODS Rat mesangial cells were incubated with L-homocysteine (L-Hcys) to determine the effects of Hcys on cell proliferation and metabolism of extracellular matrix (ECM). Northern blot, Western blot, oligonucleotide transfection, measurements of NADH oxidase activity and levels, and cell proliferation assay were performed. RESULTS In cultured rat mesangial cells, treatment with L-Hcys (40 to 160 micromol/L) markedly increased the mRNA levels of TIMP-1 and Gp91 and led to accumulation of collagen I, which were accompanied by enhanced cell proliferation and NADH oxidase activity in mesangial cells. These Hcys-induced biochemical and functional changes were substantially blocked by a NADH oxidase inhibitor, diphenylene iodonium chloride (DPI) or a superoxide dismutase (SOD) mimetic, hydroxyl-tetramethylpiperidin-oxyl (TEMPOL). Moreover, blockade of NADH oxidase subunit, phox22, by its antisense oligodeoxynucleotide also eliminated the increase in NADH oxidase activity induced by L-Hcys. CONCLUSION These results indicate that Hcys-induced alterations of ECM metabolism in mesangial cells are associated with enhanced NADH oxidase activity and that oxidative stress-stimulated up-regulation of TIMP-1 may play an important role in the deposition of collagen or ECM elements in the glomeruli during hHcys.