Miracle-dz/UniFAR-FTUs huggingface dataset:
Stage scheduling for CPU-intensive servers

The increasing prevalence of multicore, multiprocessor commodity hardware calls for server software architectures that are cycle-efficient on individual cores and can maximize concurrency across an entire machine. In order to achieve both ends this dissertation advocates stage architectures that put software concurrency foremost and aggressive CPU scheduling that exploits the common structure and runtime behavior of CPU-intensive servers. For these servers user-level scheduling policies that multiplex one kernel thread per physical core can outperform those that utilize pools of worker threads per stage on CPU-intensive workloads. Boosting the hardware efficiency of servers in userspace means a single machine can handle more users without tuning, operating system modifications, or better hardware.
Molecular crowders and cosolutes promote folding cooperativity of RNA under physiological ionic conditions

The authors show by thermal denaturation and SHAPE studies that tRNA folding cooperativity increases in physiologically low concentrations of Mg2+ (0.5–2 mM) and K+ (140 mM) if the solution is supplemented with physiological amounts (∼20%) of a water-soluble neutral macromolecular crowding agent such as PEG or dextran. Low-molecular-weight cosolutes show varying effects on tRNA folding cooperativity, increasing or decreasing it based on the identity of the cosolute.
Postoperative Outcomes After Laparoscopic Splenectomy Compared With Open Splenectomy

Objective:To evaluate 30-day postoperative outcomes in laparoscopic (LS) versus open splenectomy (OS). Summary Background Data:LS has generally been associated with lower rates of postoperative complications than OS. However, evidence mainly comes from small studies that failed to adjust for the confounding effects of the underlying indication or clinical condition that may have favored the use of one technique over the other. Methods:A retrospective cohort study of patients undergoing splenectomy in 2008 and 2009 using data from the American College of Surgeons National Surgical Quality Improvement Program database (n = 1781). Retrieved data included 30-day mortality and morbidity (cardiac, respiratory, central nervous system, renal, wound, sepsis, venous thromboembolism, and major bleeding outcomes), demographics, indication, and preoperative risk factors. We used multivariate logistic regression to assess the adjusted effect of the splenectomy technique on outcomes. Results:A total of 874 (49.1%) cases had LS and 907 (50.9%) had OS. After adjusting for all potential confounders including the indication and preoperative risk factors, LS was associated with decreased 30-day mortality [OR (odds ratio): 0.39, 95% CI: 0.18–0.84] and postoperative respiratory occurrences (OR: 0.46, 95% CI: 0.27–0.76), wound occurrences (OR: 0.37, 95% CI: 0.11–0.79), and sepsis (OR: 0.52, 95% CI: 0.26–0.89) when compared with OS. Patients who underwent LS also had a significantly shorter total length of hospital stay and were less likely to receive intraoperative transfusions compared with patients who underwent OS. Conclusions:LS is associated with more favorable postoperative outcomes than OS, irrespective of the indication for splenectomy or the patient's clinical status.
On Gaussian wiretap channels with M-PAM inputs

This paper investigates the secrecy capacity of the Gaussian wiretap channel with M-PAM inputs, by capitalizing on the relationship between mutual information and minimum mean squared error (MMSE). In particular, we establish optimality conditions for both the M-PAM input power and the M-PAM input distribution, which we specialize to the asymptotic low-power and high-power regimes. By using the properties of the MMSE to establish sufficient conditions for the uniqueness of the solution of some of the underlying non-convex optimization problems, we also propose efficient algorithms to compute the optimal solutions. Interestingly, we show that with M-PAM inputs it is sub-optimal to use all the available power for some range of parameters — this is in sharp contrast to standard Gaussian channels. We also extend the results to the parallel Gaussian wiretap channel with M-PAM inputs. We put forth a mercury-waterfilling interpretation of the optimal power allocation procedure for parallel Gaussian wiretap channels which generalizes the conventional mercury-waterfilling interpretation for parallel Gaussian channels, with the mercury level amending the base level to account for both the non-Gaussianess of the input and the secrecy constraint.
Twinning and Multiple Birth Rates According to Maternal Age in the City of São Paulo, Brazil: 2003–2014

The present study investigates the twinning rates in the city of São Paulo, Brazil, during the years 2003–2014. The data were drawn from the Brazilian Health Department database of Sistema de Informações de Nascidos Vivos de São Paulo—SINASC (Live Births Information System of São Paulo). In general, more information is available on the incidence of twinning in developed countries than in developing ones. A total of 24,589 twin deliveries and 736 multiple deliveries were registered in 140 hospitals of São Paulo out of a total of 2,056,016 deliveries during the studied time period. The overall average rates of singleton, twin, and multiple births per 1,000 maternities (‰) were 987.43, 11.96 (dizygotic (DZ) rate was 7.15 and monozygotic (MZ) 4.42), and 0.36, respectively. We further regressed maternal age and historical time period on percentage of singleton, twin, and multiple birth rates. Our results indicated that maternal age strongly positively predicted twin and multiple birth rates, and negatively predicted singleton birth rates. The historical time period also positively, although weakly, predicted twin birth rates, and had no effect on singleton or multiple birth rates. Further, after applying Weinberg's differential method, we computed regressions separately for the estimated frequencies of DZ and MZ twin rates. DZ twinning was strongly positively predicted by maternal age and, to a smaller degree, by time period, while MZ twinning increased marginally only with higher maternal age. Factors such as increasing body mass index or air pollution can lead to the slight historical increase in DZ twinning rates. Importantly, consistent with previous cross-cultural and historical research, our results support the existence of an age-dependent physiological mechanism that leads to a strong increase in twinning and multiple births, but not singleton births, among mothers of higher age categories. From the ultimate perspective, twinning and multiple births in later age can lead to higher individual reproductive success near the end of the reproductive career of the mother.
The Placenta Is Capable of Compensating for Smoking-Induced Thiocyanate Inhibition of Its Iodide Symporter

Does the Risk of Malignancy Increase When a Thyroid Nodule Is Larger Than 2 cm? 109 Kamran SC, Marqusee E, Kim MI, Frates MC, Ritner J, Peters H, Benson CB, Doubilet PM, Cibas ES, Barletta J, Cho N, Gawande A, Ruan D, Moore FD Jr, Pou K, Larsen PR, Alexander EK . Thyroid nodule size and prediction of cancer . J Clin Endocrinol Metab 2013;98:564-70 . Epub December 28, 2012; doi: 10 . 1210/jc . 2012-2968 .
Clinical analyses on salvage lymphadenectomy through cervical incision for patients with cervical and cervicothoracic recurrences after esophagectomy.

Background Locoregional recurrences are often observed after esophagectomy with lymphadenectomy. The treatment strategy for these patients has not been established completely. The purpose of this study was to evaluate the prognosis of salvage lymphadenectomy through the cervical incision for cervical and cervicothoracic recurrences. Methods We retrospectively reviewed patients underwent initial esophagectomy and then salvage lymphadenectomy in Fudan University Shanghai Cancer Center during July 2006 and September 2016. Survival curve was calculated by Kaplan-Meier method. Prognostic factors for post-salvage lymphadenectomy overall survival (PSL-OS) were identified by univariate and multivariate analyses. Results The median disease-free survival (DFS) was 8 months. The median PSL-OS was 40 months (95% CI: 8.850-71.150). The 1-, 2-, 3- and 5-year PSL-OS rate were 87%, 58%, 52% and 41%, respectively. Univariate and multivariate analyses confirmed the initial TNM stage was the only independent prognostic factor for PSL-OS (P=0.000 by log-rank test, P=0.009 by Cox hazards model, HR 3.999, 95% CI: 1.413-11.316) among these patients. Conclusions PSL survival could be considerable for patients with early initial tumor stage. Prospective studies are warranted to clarify the value of salvage lymphadenectomy.
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Disseminated, eruptive molluscum contagiosum lesions in a psoriasis patient under treatment with methotrexate and cyclosporine.

ejd.2011. 1592 Auteur(s) : Christina Fotiadou cifotiadou@hotmail.com, Elizabeth Lazaridou, Dionysios Lekkas, Alexandra Kourouklidou, Ioannides Demetrios First Department of Dematology-Venereology, Aristotle University Medical School, Thessaloniki, Greece A 70-year-old male patient with a four year history of plaque psoriasis presented in the psoriasis clinic of our department due to an abrupt deterioration of his clinical condition. The patient had been receiving methotrexate (15 mg/week) for [. ]
Too much or too little: Hyper- and hypo-reactivity in high-functioning autism spectrum conditions

Abstract Background Sensory reactivity in people with autism spectrum conditions (ASC) has been found to differ in comparison to reactivity in people without ASC. In this study sensory experiences of high-functioning individuals with ASC were explored and described. Method Interview data from 15 participants with a diagnosis of ASC were analysed by content analysis. Results Seven aspects of sensory experiences were identified: Being hyper- and hypo-reactive, reacting to general overload, having strong stimuli preferences, managing attentiveness to stimuli, managing sensory/motor stimuli, and dealing with consequences of sensory reactions in daily life. Conclusions The categorisation of sensory reactivity in this study can guide clinicians on how to pose questions about sensory issues to individuals with ASC. The assessment of spectrum-specific sensory experiences in high-functioning ASC and their association with other social and nonsocial features of ASC are goals for further research.
Modeling Conditional Forecast Error for Wind Power in Generation Scheduling

The integration of wind power requires additional operating reserves to cope with the uncertainty in power system operation. Previous research shows that the uncertainty of the wind power forecast varies with the level of its output. Therefore, allocating reserves dynamically according to the specific distribution of the wind power forecast would benefit system scheduling. This paper presents a statistical model to formulate the conditional distribution of forecast error for multiple wind farms using copula theory. The proposed model is tested using a set of synchronous data of wind power and its day-ahead forecast. It is then utilized in a stochastic unit commitment model to simulate the day-ahead and real-time scheduling of the modified IEEE RTS-79 system integrating wind power. The results show that scheduling reserves dynamically according to the modeled conditional forecast error reduces the probability of reserve deficiency while maintaining the same level of operating costs.
A provisional transport mechanism for a chloride channel-type Cl−/H+ exchanger

Chloride channel (CLC)-type Cl−/H+ exchangers are widespread throughout the biological world, and one of these, CLC-ec1 from Escherichia coli, has been extensively studied. The structure of this protein is known, and several of its mechanistic hot spots have been identified, but a mechanism for Cl−/H+ exchange has not previously been offered. We herein confirm by direct measurements of Cl− and H+ fluxes a Cl−-to-H+ exchange stoichiometry of 2, and summarize experimental facts pertinent to the exchange mechanism. While the mechanism must involve a conformational cycle of alternating exposure of substrate-binding sites to the two sides of the membrane, CLC transporters do not adhere to a familiar ping-pong scheme in which the two ions bind in a mutually exclusive fashion. Instead, Cl− and H+ occupy the ion-binding region simultaneously. A conformational cycle is proposed that accounts for the exchange stoichiometry, several key mutants and the tendency of the protein to become uncoupled and allow ‘slippage’ of Cl−.
Degradation of humic acid in soil aqueous extract using the fenton reaction and a microbiological technique

In this study, the degradation of humic acid (HA) extracted from soil in aqueous solution was carried out using the Fenton reaction and a microbiological technique. The Fenton reaction produced hydroxyl radicals (•OH) from the catalytic decomposition of hydrogen peroxide (H2O2) by the soluble ferrous ion (Fe 2+ ) for use in the destruction of organic pollutants. At pH 3.0, the ratios of HA and H2O2 of 1:560 and the H2O2 and Fe 2+ ratios of 5:1 showed the maximum percentage of HA removal. Thus, the optimal ratio of HA:H2O2:Fe 2+ for HA removal appeared to be 1:560:112. However, the highest HA removal per gram of soil was 30% after 3 h when using a ratio of humic acid to reagents (H2O2 and Fe 2+ ) of 1:11200:2240. The comparative evaluation of two microorganisms Pseudomonas fluorescens and Lactococcus lactis for the degradation of HA indicated the highest removal of about 28% when using Lactococcus lactis as a single culture for soil samples within 20 d.
Aggregate measures of ecosystem services: can we take the pulse of nature?

National scale aggregate indicators of ecosystem services are useful for stimulating and supporting a broad public discussion about trends in the provision of these services. There are important considerations involved in producing an aggregate indicator, including whether the scientific and technological capacity exists, how to address varying perceptions of the societal importance of different services, and how to communicate information about these services to both decision makers and the general public. Although the challenges are formidable, they are not insurmountable. Quantification of ecosystem services and dissemination of information to decision makers and the public is critical for the responsible and sustainable management of natural resources.
N-acetylcysteine inhibits post-impact chondrocyte death in osteochondral explants.

BACKGROUND Chondrocyte death has been linked to injury-induced oxidative damage, suggesting that antioxidants could substantially improve viability. However, since reactive oxygen species play roles in normal physiology, there are concerns that antioxidants may have deleterious side effects. To address these issues, we studied the effects of N-acetylcysteine, a potent free radical scavenger, on chondrocyte viability and cartilage proteoglycan content in an in vitro cartilage injury model. We hypothesized that treatment with N-acetylcysteine soon after an impact injury would have significant chondrocyte-sparing effects and would prevent injury-induced proteoglycan losses. METHODS Bovine osteochondral explants were subjected to a single impact load with use of a drop-tower device. Chondrocyte viability was measured at multiple time points post-impact with use of fluorescent probes and confocal microscopy. Forty-eight hours after impact, the effects on viability of immediate post-impact treatment with N-acetylcysteine were compared with the effects of the caspase inhibitor N-CBZ-Val-Ala-Asp(O-Me) fluoromethyl ketone and those of the cell-membrane-stabilizing surfactant poloxamer 188. The effect of N-acetylcysteine on proteoglycan content was determined at seven and fourteen days post-impact. RESULTS Chondrocyte viability declined sharply within an hour and reached a steady state within six to twelve hours after impact. Immediate treatment with N-acetylcysteine doubled the number of viable chondrocytes assayed forty-eight hours after impact, and this effect was significantly greater than that of N-CBZ-Val-Ala-Asp(O-Me) fluoromethyl ketone. Even when N-acetylcysteine treatment was delayed for up to four hours after injury, it still had significant positive effects on cell viability at forty-eight hours. Moreover, N-acetylcysteine treatment significantly improved proteoglycan content at the impact sites at both seven and fourteen days after injury. CONCLUSIONS Treatment with N-acetylcysteine soon after a blunt impact injury can reduce chondrocyte death and proteoglycan loss measured seven to fourteen days after injury.
Cyclosporine minimization decreases the risk of post-transplantation diabetes mellitus : 10-year single center experience in west China

Post-transplantation diabetes mellitus (PTDM) is a serious metabolic complication after liver transplantation (LT) with calcineurin inhibitor (CNI) immunosuppression. To investigate the impact of minimum CsA strategy after 6 months on PTDM and identify the risk factors of PTDM, we retrospectively analyzed the data of 168 liver recipients with cyclosporine A (CsA) between March 1999 and September 2013 in West China Hospital Liver Transplantation Center. Of the 168 recipients with median follow-up time of 32 months (6-195 months) in this study, 44 (26.2%) recipients developed PTDM after 6 months post-LT and the cumulative incidence increased with follow-up. The mean cCsA of the PTDM group was significantly higher than that of the non-PTDM group (7.66 ng/mL±3.41 vs. 4.47 ng/mL±2.22, P<0.05). And the PTDM group recipients had lower 1-, 3-, 5-, 10-year overall survival rates (83.8%, 56.2%, 49.2%, 49.2% vs. 92.5%, 78.5%, 73.6%, 70.1%, P<0.05) and allografts survival rates (92.7%, 81.5%, 71.3%, 71.3% vs. 98.4%, 92.8%, 91.2%, 88.8%, P<0.05) than the others. The best cutoff of mean cCsA to predict PTDM was 129.5 ng/mL after 6 months post-LT. Multivariate analysis showed that elder recipient at LT (age >50), hypertension pre-LT, dyslipidemia pre-LT, and high mean cCsA (≥129.5 ng/mL) 6 months post-LT were independent risk factors of PTDM after liver transplantation. Late minimum CsA strategy after 6 months decreased the risk of PTDM after liver transplantation.
A rectangular waveguide filter with integrated E-plane probe transition

A novel Rectangular waveguide (RWG) filter with integrated transitions is proposed in this letter. The E-plane probe transition, which is employed to couple the energy from the RWG resonator to the microstrip line (MSL), is used as the external coupling mechanism. The integrated design of the filter and transition can reduce the design complexity and size of the circuit. In order to verify the design, a prototype of the filter is fabricated and measured. It provides an in-band return loss and insertion loss of better than 14.6 and 1.5 dB, respectively, in the frequency range of 8.39 to 8.85GHz.
Synergistic interaction between quercetin and doxorubicin on MCF-7 human breast cancer cell line

The effectiveness of doxorubicin has decreased due to resistance of cancer cells. One of the natural ingredients that are proven to reduce the resistance to anticancer is quercetin. Quercetin interacts with doxorubicin via a competition of P-glycoprotein (P-gp) transporter activity. The aim of this study is to evaluate the interaction of quercetin and doxorubicin as cytotoxicity effect on MCF-7 cells. Cytotoxicity test was conducted by the MTT method. Mechanism of interaction between doxorubicin and quercetin was evaluated with isobologram analysis. Doxorubicin and quercetin inhibited the growth of MCF-7 cells significantly. Doxorubicin and quercetin respectively had IC50 of 21M and 103 M. The interaction of doxorubicin and quercetin were characterized by the amount of doxorubicin IC50 equivalent and quercetin IC50 equivalent less than 1 and the point-intercept of each IC50 notation equivalent plotted on the graph below the additive line. Analysis of isobolograms indicated that the interaction doxorubisn and quercetin in each of the ratios had synergy. Quercetin can be considered to be in a combination wit
Chemical Composition and Fumigant Toxicity of Artemisia absinthium Essential Oil Against Rhyzopertha dominica and Spodoptera littoralis

Dhen, N. , Majdoub, O. , Souguir S. , Tayeb, W. , Laari f A. , and Chaieb I. 2014. Chemical composition and fumigant toxicity of Artemisia absinthium essential oil against Rhyzopertha dominica and Spodoptera littoralis. Tunisian Journal of Plant Protection 9: 57-65. Natural products are excellent alternative to synth etic pesticides due to their reduced harmful impact s on human health and environment. Pesticides based o n plant essential oils or their constituents have demonstrated efficacy against a range of pests and preand postharvest diseases. In this study, the pesticide potentiality of the essential oils from t he absinthe wormwood Artemisia absinthium (Asteraceae) was investigated against two insect pests i.e. Rhyzopertha dominica nd Spodoptera littoralis. Essential oil of the aerial parts was obtained by hydrodistillation and was analyzed by GC– MS in order to determine its chemical composition. The major components identified were: camphor (24.81%), camazulene (13.17%), bronylacetate (5.89% ), and myrcene (5.83%). The essential oil of A. absinthium exhibited strong fumigant toxicity against R. dominica adults, a stored product pest, with a LC50 value of 18.23 μl/l air and LC90 value of 41.74 μl/l air. The wormwood essential oil showed high fumigant activity against S. littoralis, one of the most dangerous pests of protected crop s, with a LC50 value of 10.59 μl/l air and a LC90 value of 17.12 μl/l air.
Cameras and Inertial/Magnetic Sensor Units Alignment Calibration

Due to the external acceleration interference/ magnetic disturbance, the inertial/magnetic measurements are usually fused with visual data for drift-free orientation estimation, which plays an important role in a wide variety of applications, ranging from virtual reality, robot, and computer vision to biomotion analysis and navigation. However, in order to perform data fusion, alignment calibration must be performed in advance to determine the difference between the sensor coordinate system and the camera coordinate system. Since orientation estimation performance of the inertial/magnetic sensor unit is immune to the selection of the inertial/magnetic sensor frame original point, we therefore ignore the translational difference by assuming the sensor and camera coordinate systems sharing the same original point and focus on the rotational alignment difference only in this paper. By exploiting the intrinsic restrictions among the coordinate transformations, the rotational alignment calibration problem is formulated by a simplified hand-eye equation AX = X B (A, X, and B are all rotation matrices). A two-step iterative algorithm is then proposed to solve such simplified hand-eye calibration task. Detailed laboratory validation has been performed and the good experimental results have illustrated the effectiveness of the proposed alignment calibration method.