Miracle-dz/UniFAR-FTUs huggingface dataset:
INSL4 as prognostic marker for proliferation and invasiveness in Non-Small-Cell Lung Cancer

Non-small-cell-lung cancer accounts for 80-85% of all forms of lung cancer as leading cause of cancer-related death in human. Despite remarkable advances in the diagnosis and therapy of lung cancer, no significant improvements have thus far been achieved in terms of patients' prognosis. Here, we investigated the role of INSL4 - a member of the relaxin-family - in NSCLC. We overexpressed INSL4 in NSCLC cells to analyse in vitro the growth rate and the tumourigenic features. We investigated the signalling pathways engaged in INSL4 overexpressing cells and the tumour growth ability by studying the tumour development in a patient derived tumour xenograft mouse model. We found an INSL4 cell growth promoting effect in vitro in H1299 cells and in vivo in NOD/SCID mice. Surprisingly, in NSCLC-A549 cells, INSL4 overexpression has not similar effect, despite huge basal INSL4-mRNA expression respect to H1299. The INSL4-mRNA analysis of eight different NSCLC-derived cell lines, revealed highly difference in the INSL4-mRNA amount. Transfection of NSCLC lines with INSL4-Myc showed huge level of INSL4-mRNA with a very low amount of protein expressed. Notably, similar discrepancy has been observed in NSCLC patients. However, in a cohort of NSCLC patients analysing a database, we found a significant inverse correlation between INSL4 expression and Overall Survival. By combining the in vitro and in vivo results, suggest that in patients whose NSCLC adenocarcinoma spontaneously expressed high levels of INSL4 post-transcriptional modifications affecting INSL4 do not allow to assess precision therapy in selected patients without consider protein INSL4 amount.
Frequency of Psychiatric Symptoms and Associated Factors During Pregnancy

Notably, psychiatric disorders during the perinatal period are a significant health concern, especially in developing countries. Psychiatric disorders during this period are common, based on the disease spectrum (major depression, anxiety disorders, obsessive-compulsive disorder, and other disorders like social phobia) and prevalence (studies specifically showing depression ranged from 8.0% to 41.0%). [2-5] Besides affecting the mother during the perinatal period, the psychiatric disorders cause complications, such as preterm delivery, low birth weight, and insufficient growth, in the postnatal period. [6-10] In addition to the biological factors, the biodemographic, sociodemographic, socioeconomic, and sociocultural factors are among the reasons for perinatal psychiatric disorders. [11-16] Objectives: Psychiatric disorders are a significant health concern during the perinatal period. Therefore, this study determined the prevalence of psychiatric symptoms and their associated factors during pregnancy.
Identification of EEG Fingerprints of Simultaneous fMRI in Resting State and Motor Imagery

Over the past few years, simultaneous EEG-fMRI recordings have been largely used to understand the link between EEG and fMRI in multiple conditions. The use of multimodal approaches that combine the two modalities has received recognition a promising new tool, owing to their highly complementary characteristics. However, such multimodal acquisitions are typically costly, non-portable and overall uncomfortable for patients, mostly due to the use of fMRI. This motivated the search for solutions capable of using only the widely available EEG as a surrogate of the simultaneous BOLD signal. Within this scope, this work investigated an integration strategy whereby relevant EEG-features were extracted and their coefficient estimates learnt so as to predict the simultaneous average BOLD signal measured at a specific distributed network. These network-specific EEG patterns were here referred to as EEG-Fingerprints (EFPs), a concept introduced by Meir-Hasson and their colleagues (MeirHasson et al., 2014). The methodology employed relied on a machine learning approach that included linear regression algorithms and cross validation procedures. Independent analyses were performed for data recorded under two experimental conditions: during resting state; and during a motor imagery task.
Rheological and structural properties of tomato ketchup as affected by the addition of native and modified starches

Dzhivoderova-Zarcheva, M. , Nikovska, K. & Dimova, K. (2021). Rheological and structural properties of tomato ketchup as affected by the addition of native and modified starches. Bulg. J. Agric. Sci., 27 (1), 220–226 It was investigated to determine the effect of several modified and/or native starches like a thickening agent, at levels of 5% on the rheological properties, consistency and syneresis of tomato ketchups. Two ketchup model systems: A (without tomato paste) and B (with tomato paste), were analyzed. Тhe model systems A and B were non-Newtonian fluids, and their viscosity variations were closely. In general, corn starches exhibited lower Bostwick values than potato starches, especially when native corn starch was applied. With higher value of Bostwick consistency was the system A with Acetylated distarch phosphate from potato starch – 8.50±0.43 сm and with lower was the system A with Acetylated distarch adipate from waxy maze starch + Native corn starch (1:1) (ADA-WMS+NCS) аnd Native corn starch (NCS) – 1.00±0.05 сm. Addition of tomato paste significantly affected the consistency and the syneresis resistancy of the systems. The highest value of the separated liquid (in %) for system B was the sample with ADP-PS (13.01±0.65%), аnd the lowest – the sample with NCS (1.77±0.09%). On the basis of these results, the most suitable for the production of ketchup tomato and in order to reduce also the modified starch, it can be used the acetylated distarch adipate from waxy corn and native corn starch in equal proportions or only native starch.
Journal of Business Systems, Governance and Ethics

This paper gives an illustration of the Upper Echelon Theory and presents arguments for more research on the relationship between upper echelons, strategic choices, and ethical behaviour. Its central theme is: What is the effect of the Sarbanes-Oxley Act implementation on the composition of the Board of Directors of companies that are listed on a U.S. stock exchange? In this research we examined whether the composition of companies’ top management teams is influenced by the issue of ethical behaviour. We used a sample of fifty listed companies, containing the members of the Board of Directors registered in the period 2000 2005. The underlying question in this research is whether companies actually change the composition of their Board of Directors because they believe that personal characteristics, such as age, tenure, and specialisation, play an important role in decision making and hence in the degree of their ethical behaviour. In this paper we test three hypotheses. The conclusion is that two of our hypotheses support the Upper Echelon Theory.
DOXORUBICIN-LOADED MICELLES OF Y-SHAPED PEG-(PCL)2 AGAINST DRUG-RESISTANT BREAST CANCER CELLS

Y-shaped amphiphilic copolymers have been synthesized by various strategies. They can self-assemble to form stable micellar drug carriers. Higher ratio of hydrophobic segment in these micelles is known to stabilize encapsulated drugs. This study used methoxy poly(ethylene glycol) (mPEG, A block) and poly(e-caprolactone) (PCL, B block) to synthesize an AB2 type amphiphilic block copolymer to encapsulate the anticancer drug, doxorubicin (DOX). The synthesized mPEG-(PCL)2 self-assembled into nanoparticles and its critical micelle concentration was 43.7 × 10-3 mg/mL. The particle size of empty micelle and DOX-loaded micelle was 95.1 and 21.4 nm, respectively. DOX-loaded micelles have a drug- loading efficiency of 22.3% and could be released from micelles up to 50% at pH 5 and 40% at pH 7.4 in 48 h in an in vitro release experiment. The nitric oxide (NO) assay indicated that the micelles could avoid the cytotoxic recognition by murine macrophage cells. The half-lethal dose (IC50) of DOX-loaded micelles for two.
Frequencies of Long-Wave Phonon-Polaritons

Long-wave phonon-polaritons and longitudinal optical phonons in ionic crystals with two atoms per unit cell have been considered. The model of the point charge and the self-consistent electromagnetic field in the dielectric medium is used. The standard dispersion laws for both branches of phonon-polaritons regarded as transversal waves are obtained. The frequency of longitudinal optical phonons is expressed in terms of the ion plasma frequency in an insulator multiplied by the factor √︀ ε0/(ε0 − ε∞), where ε0 is the static dielectric constant, and ε∞ is the high-frequency one. A good agreement between the found expression and tabulated data is found.
Cottonseed Treatment in Addition to Chemical Control of Sporadic Pests for the Small Scale Farmer

Cottonseed treatment trials over two to three seasons showed that phorate and terbufos have potential as seed dressings to protect young cotton plants against pests. Bio-assays indicated that germinating cotton plants are capable of absorbing and transporting sufficient insecticide to produce satisfactory mortality in pests such as Syagrus rugifrons Baly the black cotton beetle, and other ground insects, e.g. crickets, that damage cotton seedlings. The black cotton beetle is a pest on cotton seedlings and ratoon cotton on the Springbok Flats in the Northern Province. Soil treatment and seed treatment with terbufos effectively prevented root damage early in the season, while follow-up applications of monocrotophos or abamectin in combination with endosulfan (Thioflo), controlled plant damage above the soil. Endosulfan in combination with profenofos and carbaryl resulted in significant yield increases. Monocrotophos simultaneously controls the American bollworm (Helicoverpa armigera Hübner), the main pest of cotton. Monocrotophos also shows potential to control the cotton stem weevil, Apion soleatum Wagner (Apionidae: Coleoptera), a relatively new pest in the lowveld areas of KwaZulu-Natal and Mpumalanga, where many small-scale farmers produce cotton. An integrated pest management programme that includes seed treatment and limited use of insecticides that control a number of pest species at the same time, is suggested for small-scale farmers.
Improved reliability of Ti/ZrN/Pt resistive switching memory cells using hydrogen postannealing

The authors investigated the effects of hydrogen postannealing on data retention and set/reset current variation in a Ti/ZrN/Pt resistive switching memory cell. Annealing the Ti/ZrN/Pt sample in a N2 + H2 ambient gas versus a N2 ambient gas reduced the set currents from 10.4 to 4.1 mA and the reset currents from 1.2 to 0.2 μA, whereas the current ratio increased from ∼9 × 103 to ∼2 × 104. In addition, current variations in the set and reset states decrease at temperatures of 25 and 85 °C (>10yr) due to reduction of the interface trap by hydrogen passivation effects.
Which is Better for Deep Learning: Python or MATLAB? Answering Comparative Questions in Natural Language

We present a system for answering comparative questions (Is X better than Y with respect to Z? ) in natural language. Answering such questions is important for assisting humans in making informed decisions. The key component of our system is a natural language interface for comparative QA that can be used in personal assistants, chatbots, and similar NLP devices. Comparative QA is a challenging NLP task, since it requires collecting support evidence from many different sources, and direct comparisons of rare objects may be not available even on the entire Web. We take the first step towards a solution for such a task offering a testbed for comparative QA in natural language by probing several methods, making the three best ones available as an online demo.
Are Smartphones Enhancing or Displacing Face-to-Face Communication With Close Ties? A Panel Study Among Adults

Previous research has revealed inconsistent findings regarding enhancement or displacement of face-to-face (FtF) communication due to social media and smartphone use. We argue that the occurrence of enhancement or displacement effects is contingent on the specific type of smartphone use. Specifically, we tested how adults’ communicative and noncommunicative smartphone uses influence the quantity of FtF communication and quality of relationships with family and friends. Results of a two-wave panel survey (NTime2 = 461) revealed a positive influence of communicative smartphone use on quantity of FtF communication with family and friends, supporting the enhancement hypothesis. Quality of relationships with close ties, however, was not influenced by communicative smartphone use. In line with the displacement hypothesis, we found a negative influence of noncommunicative smartphone use on quantity of FtF communication with close ties, but not on quality of relationships with family and friends.
Strengthening breast surgery workforce capacity: implementation of competency-based training programme

Background and rationale Quality education is a prerequisite for building a sustainable health system. To address this requirement, it is necessary to strengthen capacity and expand the training opportunities to ensure equitable and efficient development of core professional competencies for specific contexts and educational needs. Methods and results A competency-based training programme for Breast Surgeons was built and was applied based on the Consolidated Framework for Implementation Research (CFIR). This framework provides a pragmatic structure for approaching complex interactions, multi-level and transient constructs in the real world. CFIR guided the implementation process and verified what works, where and why across each step. CFIR guided implementation was through an adaptable approach of the domains and creating relevant constructs that set up an ideal roadmap to analyse and improve learning needs, the curriculum design and the learning environment. Conclusion The outcomes described in this manuscript demonstrate that evidence-based principles can be implemented in health professionals’ training and clinical practice even in resource-constrained settings. Building strong and sustainable healthcare workforce capacity is an urgent need for improved health service delivery and addresses real-life workplace needs in low-middle income countries. This programme integrates training with service to solve problems and develop initiatives to address existing local health priorities. While the article focuses on a training programme development, findings are shared to promote dissemination into other settings.
Iron(III) Oxides from Thermal ProcessesSynthesis, Structural and Magnetic Properties, Mössbauer Spectroscopy Characterization, and Applications†

Structural and magnetic properties, methods of synthesis, and applications of seven iron(III) oxide polymorphs, including rare beta, epsilon, amorphous, and high-pressure forms, are reviewed. Thermal transformations resulting in the formation of iron oxides are classified according to different parameters, and their mechanisms are discussed. 57Fe Mossbauer spectroscopy is presented as a powerful tool for the identification, distinction, and characterization of individual polymorphs. The advantages of Mossbauer spectroscopy are demonstrated with two examples related to the study of the thermally induced solid-state reactions of Fe2(SO4)3.
Optimized PV-coupled battery systems for combining applications: impact of battery technology and location

Interest in residential batteries to supply photovoltaic (PV) electricity on demand is increasing, however they are not profitable yet. Combining applications has been suggested as a way to increase their attractiveness, but the extent to which this can be achieved, as well as how the different value propositions may affect the optimal battery technology, remain unclear. In this study, we develop an open-source optimization framework to determine the best-suited battery technology depending on the size and the applications combined, including PV selfconsumption, demand load-shifting, demand peak shaving and avoidance of PV curtailment. Moreover, we evaluate the impact of the annual demand and electricity prices by applying our method to representative dwellings in Geneva, Switzerland and Austin, Texas in the United States. Our results indicate that the combination of applications help batteries to become close to break-even by improving the net present value by up to 66% when compared with batteries performing PV self-consumption only. Interestingly, we find that the best-suited battery technology in Austin is lithium nickel cobalt aluminum oxide (NCA) as for Geneva lithium nickel manganese cobalt oxide (NMC) batteries reach in average a higher net present value than NCA-based batteries. However, NCA-based batteries could be a more promising alternative in the future.
Longnon-coding RNA BLACAT2 promotes gastric cancer progression via the miR-193b-5p/METTL3 pathway

Gastric cancer is one of the leading prevalent and malignant cancers worldwide, especially in east Asia. However, the in-depth molecular mechanism underlying gastric cancer progression remains uncertain. Recently, studies have identified that long non-coding RNA (lncRNA) could play critical roles in the tumorigenesis of multiple types of cancer. Studies on long non-coding RNA BLACAT2 have proven that it participates in bladder cancer and colorectal cancer regulation and was identified as highly expressed using the cBioPortal for Cancer Genomics in gastric cancer. However, the precise function of lncRNA-BLACAT2 in the carcinogenesis and progression of gastric cancer remains largely unexplored. Our study discovered that lncRNA-BLACAT2 was significantly upregulated in gastric cancer. Different studies have illustrated that BLACAT2 promoted gastric cancer progression through regulating proliferation, migration, invasion, and apoptosis in terms of biological function. Furthermore, BLACAT2 was verified to perform its function through interaction with miR-193b-5p using a luciferase reporter assay. On the other hand, MiR-193b-5p specific inhibitor treatment reversed the inhibitory effect of BLACAT2 on cell biological functions. Additional studies also discovered that Methyltransferase Like 3 (METTL3) was the downstream target of miR-193b-5p. Subsequently, restoration of METTL3 eliminated the suppressive effect of proliferation or the promotive effect of apoptosis caused by BLACAT2 knockdown. To sum up, these experimental results demonstrated that BLACAT2 acted as an oncogene in gastric cancer progression through the regulation of the miR-193b-5p/METTL3 pathway, hence providing new insights regarding the pathogenesis of gastric cancer.
Results of Newborn Hearing Screening, Tepecik Education and Research Hospital

Hearing screening is used in all newborns to ensure that infants who have problems in hearing are diagnosed at the earliest time in the most definite and appropriate way. The rate of congenital hearing loss is between 0.1% and 0.6% in all healthy newborns. [1] A simple newborn hearing screening will provide an early diagnosis of hearing loss, which can influence the infant's future life and success. [2] It is most ideal for all newborns to be screened within 12–24 h after birth, 30 minutes after feeding, in their natural sleep. The babies who failed the test and were rescreened and passed the test with both ears before their discharge were considered to be normal. The method used in screening should be able to detect hearing losses of ≥30 dB in the frequency region required for the speech of children and normal development. [3] Objectives: This study aimed to emphasize the significance of newborn hearing screening for detecting congenital hearing loss within the first 6 months of birth.
1_The Different

Good quality velvet beans and zinc supplement are well studied and known as rich source of aphrodisiac. The following reseach was carried out to study the difference effect of zinc supplement (ZS) and velvet bean extracts (VBE) towards fertility of BALB/c mice i.e the number of sperm, the motility of sperm, the viability of sperm, the morphology of sperm, the existence of vagina plug, and the birth condition of mice. This study was an experiment using Posttest Only Controlled Group Design with three groups. The first group (A1) as control, the second group (A2) receives subcutaneous injection of 2methoxyethanol fraction as much as 200 mg/kg weight/day for 5 days, followed with ZS at a dosage of 0,026 mg/day/head, and the third group (A3) receives subcutaneous injection of 2-methoxyethanol fraction as much as 200 mg/kg weight/day for 5 days, followed with VBE at a dosage of 56 mg/kg weight /day for 30 days. The quality of spermatozoa of A1, A2, and A3 was significant difference (p < 0.05). Both of A2 and A3 were no significant difference of mean number of sperm (p = 0.274), mean percentage of sperm motility (p = 0.739), mean percentage of sperm viability (p = 0.141) and mean value of morphology of sperm (p = 0.394). The quality of spermatozoa and the total number of baby mice lived and died of A1, A2 and A3 were significant difference. In addition, there was no significant difference in the existence of female mice's vaginal plug of A1, A2 and A3. This study showed that ZS and VBE can increase the quality of spermatozoa of BALB/C mice.
Why the Internet holds firm: Internet infrastructure in times of COVID-19

The role of the network of subnetworks, once established for research purposes and now known as the Internet, has evolved within a few decades into an omnipresent communication and commercial ecosystem. At the end of 2018, more than 50% of the world’s population, 3.9 billion people from all countries of the world, were using the Internet – and the trend is growing. According to a Cisco1 forecast, by 2023 there will be 29.3 billion devices worldwide connected to the Internet (or 3.6 devices for every person on the planet), which will send and receive a total of 1,209 terabits per second (Tbps) of Internet traffic at peak times – the equivalent of about 48 million parallel Netflix 4K streams. According to these estimates, the data traffic of the future will therefore assume enormous proportions.
Robust Mathematical formulation and Probabilistic Description of Agent-based Computational Economic Market Models

In science and especially in economics, agent-based modeling has become a widely used modeling approach. These models are often formulated as a large system of difference equations. In this study, we discuss two aspects, numerical modeling and the probabilistic description for two agent-based computational economic market models: the Levy–Levy–Solomon model and the Franke–Westerhoff model. We derive time-continuous formulations of both models, and in particular, we discuss the impact of the time-scaling on the model behavior for the Levy–Levy–Solomon model. For the Franke–Westerhoff model, we proof that a constraint required in the original model is not necessary for stability of the time-continuous model. It is shown that a semi-implicit discretization of the time-continuous system preserves this unconditional stability. In addition, this semi-implicit discretization can be computed at cost comparable to the original model. Furthermore, we discuss possible probabilistic descriptions of time-continuous agent-based computational economic market models. Especially, we present the potential advantages of kinetic theory in order to derive mesoscopic descriptions of agent-based models. Exemplified, we show two probabilistic descriptions of the Levy–Levy–Solomon and Franke–Westerhoff model.