Miracle-dz/UniFAR-FTUs huggingface dataset:
Independent Component Analysis for Unraveling the Complexity of Cancer Omics Datasets

Independent component analysis (ICA) is a matrix factorization approach where the signals captured by each individual matrix factors are optimized to become as mutually independent as possible. Initially suggested for solving source blind separation problems in various fields, ICA was shown to be successful in analyzing functional magnetic resonance imaging (fMRI) and other types of biomedical data. In the last twenty years, ICA became a part of the standard machine learning toolbox, together with other matrix factorization methods such as principal component analysis (PCA) and non-negative matrix factorization (NMF). Here, we review a number of recent works where ICA was shown to be a useful tool for unraveling the complexity of cancer biology from the analysis of different types of omics data, mainly collected for tumoral samples. Such works highlight the use of ICA in dimensionality reduction, deconvolution, data pre-processing, meta-analysis, and others applied to different data types (transcriptome, methylome, proteome, single-cell data). We particularly focus on the technical aspects of ICA application in omics studies such as using different protocols, determining the optimal number of components, assessing and improving reproducibility of the ICA results, and comparison with other popular matrix factorization techniques. We discuss the emerging ICA applications to the integrative analysis of multi-level omics datasets and introduce a conceptual view on ICA as a tool for defining functional subsystems of a complex biological system and their interactions under various conditions. Our review is accompanied by a Jupyter notebook which illustrates the discussed concepts and provides a practical tool for applying ICA to the analysis of cancer omics datasets.
Impairments of large-scale functional networks in attention-deficit/hyperactivity disorder: a meta-analysis of resting-state functional connectivity

Abstract Altered resting-state functional connectivity (rsFC) has been noted in large-scale functional networks in attention-deficit/hyperactivity disorder (ADHD). However, identifying consistent abnormalities of functional networks is difficult due to varied methods and results across studies. To integrate rsFC alterations and search for coherent patterns of intrinsic functional network impairments in ADHD, this research conducts a coordinate-based meta-analysis of voxel-wise seed-based rsFC studies comparing rsFC between ADHD patients and healthy controls. A total of 25 datasets from 21 studies including 700 ADHD patients and 580 controls were analyzed. We extracted the coordinates of seeds and between-group effects. Each seed was then categorized into a seed-network by its location within priori 7-network parcellations. Then, pooled meta-analyses were conducted for the default mode network (DMN), frontoparietal network (FPN) and affective network (AN) separately, but not for the ventral attention network (VAN), dorsal attention network (DAN), somatosensory network (SSN) and visual network due to a lack of primary studies. The results showed that ADHD was characterized by hyperconnectivity between the FPN and regions of the DMN and AN as well as hypoconnectivity between the FPN and regions of the VAN and SSN. These findings not only support the triple-network model of pathophysiology associated with ADHD but also extend this model by highlighting the involvement of the SSN and AN in the mechanisms of network interactions that may account for motor hyperactivity and impulsive symptoms.
Next-generation Virtual and Augmented Reality in Surgical Education: A Narrative Review.

BACKGROUND Virtual and Augmented Reality (VR/AR) has been used in surgery for several decades. Over the past 5-10 years, however, new technological advances, including high-resolution screens, mobile graphical processing units (mGPUs) and position-sensing technologies, have been incorporated into relatively low-cost VR and AR devices. This review focuses on the current impact of the application of these "Phase 2" VR/AR technology in surgical training. METHODS A narrative literature review was undertaken using PubMed and Web of Science to identify comparative studies related to the impact of Phase 2 VR or AR tools on surgical training, defined in terms of the acquisition of technical surgical skills. Eleven studies on the effectiveness of VR/AR in surgical education were identified for full review. Further, the grey literature was searched for articles describing the current state of VR/AR in surgical education. A quality analysis using the Newcastle Ottawa scale showed a median score of 7 (out of a maximum achievable score of 9). RESULTS All studies showed a positive association between the use of VR/AR in surgical training and skill acquisition in terms of improving the speed of acquisition of surgical skills, the surgeon's ability to multitask, the ability to perform a procedure accurately, hand-eye coordination and bimanual operation. The grey literature presented a common, positive theme of the benefits of VR/AR in surgical training. CONCLUSIONS Based on the limited evidence available, VR/AR appears to have positive training benefits in improving the speed of acquisition of surgical skills. However, the significant heterogeneity in study methodology and the relative recency of wider VR/AR adoption in surgical training mean that only tentative conclusions can be drawn at this stage. Further research, ideally with large sample sizes, robust outcome measures and longer follow-up periods, is recommended.
Perspective Discrepancy Analysis of Health Care Provider and Well-Elderly Regarding Environmental Fall Risk Factors

The purpose of this study was to discover the discrepancies in perspectives regarding environmental hazards in the home between the well-elderly and health care professionals. Interviews, discussion groups, and review of a videotape were used to gather information. The interviews and videotapes were used to gain the health care professional’s perspectives and the discussion groups were used to gather the elderly’s perspectives. This qualitative study found both similarities and discrepancies between the wellelderly and physicans. The major discrepancies were: 1) that the elderly and health care professionals are not entirely aware of environmental factors contributed to falls, 2) the physicians state that it is their role to do education of fall prevention and the physicians freely admit that they are not doing it, 3) health care professionals are not consistently addressing fall prevention with the elderly, and 4) the elderly have a fear of falling that is not recognized by the physicians.
Rituximab therapy is more effective than cyclophosphamide therapy for Japanese patients with anti‐topoisomerase I‐positive systemic sclerosis‐associated interstitial lung disease

Systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) is the most frequent cause of death for SSc but there is still no sufficient treatment available. Although cyclophosphamide (CYC) therapy is a common treatment which has shown statistical efficacy against SSc‐ILD to date, its effects are temporary and not enough. Rituximab (RTX), the anti‐CD20 monoclonal antibody, has recently shown efficacy in many autoimmune diseases. In SSc‐ILD, RTX is also considered to be one of the novel treatment candidates. However, studies of SSc‐ILD in Japanese treated with RTX have only a few case reports. Therefore, in this study, we retrospectively compared nine patients treated with RTX and 30 patients treated with CYC to investigate the efficacy of RTX treatment for Japanese anti‐topoisomerase I‐positive SSc‐ILD patients. At the 24‐month evaluation, the improvement rates of percent predicted of forced vital capacity and percent predicted of diffusing capacity of the lung carbon monoxide in the RTX‐treated group were significantly higher than those in the CYC‐treated group (20.6 ± 8.8% vs 1.1 ± 3.9%; P < 0.05 and 34.0 ± 6.0% vs −1.5 ± 2.8%; P < 0.01, respectively). In addition, skin thickness scores also showed a marked improvement from 13.5 points before the start of treatment to 5.8 points after 24 months by RTX therapy (P < 0.05). These results suggest that RTX treatment is more effective for Japanese SSc‐ILD patients than CYC treatment. In the future, it is expected that large‐scale clinical trials will show the usefulness of RTX treatment for SSc‐ILD.
The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU

ToxR and TcpP, two winged helix-turn-helix (w-HTH) family transcription factors, co-activate expression of the toxT promoter in Vibrio cholerae. ToxT then directly regulates a number of genes required for virulence. In addition to co-activation of toxT, ToxR can directly activate the ompU promoter and repress the ompT promoter. Based on a previous study suggesting that certain wing residues of ToxR are preferentially involved in toxT co-activation compared to direct ompU activation, we employed alanine-scanning mutagenesis to determine which residues in the wing of ToxR are required for activation of each promoter. All of the ToxR wing residues tested that were critical for transcriptional activation of toxT and/or ompU were also critical for DNA binding. While some ToxR wing mutants had reduced interaction with TcpP, that reduced interaction did not correlate with a specific defect in toxT activation. Rather, such mutants also affected ompU activation and DNA binding. Based on these findings we conclude that the primary role of the wing of ToxR is to bind DNA, along with the DNA recognition helix of ToxR, and this function is required both for direct activation of ompU and co-activation of toxT.
Research on the Difficulty Points Marking System of Online Learning Process

There exists a notable problem in MOOCs that teachers can’t find the difficulties during the learners’ learning process because of their inefficiency of supervising the learners’ real learning status. To solve this problem, we model the learning behavior of online learners based on facial expression information and mouse track data, and propose a method for marking learner’s difficulties in online learning process based on machine learning. At same time, we design and implement a prototype system for marking difficulties based on our method. Experiments show that our method can improve the efficiency and quality of marking learner’s difficulties effectively.
Formation of Zn-Zn and Zn-Pd Bonded Complexes by Reactions of Terminal Zinc Hydrides with Pd(II) Species.

Divalent palladium-induced homocoupling of terminal zinc hydrides to zinc-zinc bonded complexes was achieved herein. Reactions of zinc hydrides [LZnH] (L = CH3C(2,6-iPr2C6H3N)CHC(CH3)(N(CH2)nCH2PPh2); 1a: n = 1; 1b: n = 2) with 0.5 equiv of allyl(cyclopentadienyl)palladium(II) afforded heterotrinuclear [Zn2Pd] complexes 3 containing direct Zn-Zn and Zn-Pd bonds, with concomitant elimination of propylene and cyclopentadiene. Complexes 3 were also accessed by the reactions of zinc hydrides 1 with allylpalladium(II) chloride with release of propylene and hydrogen chloride. Treatment of zinc hydrides 1 with 1 equiv of allyl(cyclopentadienyl)palladium(II) gave Zn-Pd bonded complex 5 by elimination of propylene, which can be transformed into heterotrinuclear complex 3 by further reaction with one additional molar equivalent of zinc hydrides. Heterobimetallic Zn-Pd complex 5b was found to be an effective catalyst in the hydrosilylation of benzaldehyde and its derivatives. Reaction of 5b with silane reagent Ph2SiH2 produced [Pd2Si2H2] complex 8 with cleavage of the Pd-Zn bond, which served as an initiating species in the catalytic reaction. Complexes 4b, 5, and 8 in this study were characterized by X-ray diffraction.
Teacher Perception on the Implementation of (Information and Communcation Technology) ICT-Based Training in Managing Practicum of Physics

This study aims to reveal physics teachers’ perception on the implementation ofInformation and Communication Technology (ICT)-based training to improve theirprofessionalism in practicum management. There are 40 physics teachers from 25 differentsenior high schools in Bandung, Indonesia, involved in this study. This study is based onqualitative methodology using a descriptive approach. Data were collected using closedquestionnaires with interviews added Perceptions consist of 3 (three) types of spirit(enthusiasm), visibility (literacy), and absorption (success). Training is a professionalismimprovement program using andriod-based smartphones. The results show that the enthusiasmlevel reaches 85% of the participants, the visibility reaches 50% of the participants, and 70% ofthe participants identifies appropriate training. Based on the results obtained can be stated thatthe program improves the professionalism of teachers in managing practicum can be doneusing andriod-based smartphone. ICT-based practice management training program is moreeffective and efficient, and focuses on 21st century development towards Indonesia Emas(Golden Indonesia) 2045.
Produkty mięsne należące do grupy żywności funkcjonalnej z uwzględnieniem potrzeb chorych na nieswoiste stany zapalne jelit

Functional meat products designed for individuals with inflammatory bowel disease Functional meat products designed for individuals with inflammatory bowel disease The diet high in meat products may be one of the reasons of inflammatory bowel diseases. Simultaneously, the meat consumption in this group of patients is in many cases high, however it may possibly have negative impact on the symptoms of disease. On the other hand, meat functional products may have a positive influence on health and well-being of people with inflammatory bowel diseases. Important may be especially meat and meat products characterized by reduced alergenicity, reduced preservatives content, modified fatty acids composition, with probiotics, antioxidants, that may be applied in case of people with inflammatory bowel diseases instead of typical products. They may allow to enhance intake of deficit nutrients and to eliminate components of adverse effect.
Grande prématurité, risque de handicaps neuropsychiques et neuroprotection.

RÉSUMÉ L’augmentation des taux de survie des grands prématurés et des prématurissimes (< 28 semaines d’aménorrhée) ne semble pas s’accompagner d’une augmentation de la prévalence des séquelles neuropsychiques et des handicaps sévères secondaires. L’enfant né grand prématuré et surtout prématurissime reste cependant un enfant à haut risque d’infirmité motrice d’origine cérébrale et d’insuffisance mentale. L’atteinte de la substance blanche avec les leucomalacies périventriculaires et les hémorragies intra-parenchymateuses constituent la menace la plus redoutable pour le cerveau en développement de ces enfants. Les progrès récents de l’épidémiologie, de la neurobiologie du développement et de l’imagerie nous permettent de progresser dans la compréhension des mécanismes à l’origine des lésions et laissent entrevoir des espoirs pour leur prévention. La prévention de la grande prématurité reste néanmoins un objectif prioritaire. La lutte contre les infections nécessite leur dépistage précoce. L’utilisation de substances prévenant la mort cellulaire retardée (anti-radicalaires, antagonistes des cytokines, antagonistes de la cascade excitotoxique, facteurs de croissance) telles que le sulfate de magnésium sont probablement des voies d’avenir.
The oncogenic role and the prognostic value of NOTCH3 gene in human malignant glioma

Mohammad A.Y. Alqudah, Zita Sibenaller, Timothy C. Ryken and Mahfoud Assem. NOTCH3 is a prognostic factor and critical element in gliomagenesis. Health Sciences Research Week–translational genomics, University of Iowa, IA, 2013. Mohammad A.Y. Alqudah, Supreet Agarwal, Maha S. Al-Keilani, Zita Sibenaller, Timothy C. Ryken and Mahfoud Assem. NOTCH3: A Potential Predictive Biomarker in Malignant Glioma. Presented at the American College of Clinical Pharmacy annual meeting, 2012 October 21 24; Hollywood, Florida (FL): ACCP; 2012. Abstract # {203}. Mohammad A.Y. Alqudah, Supreet Agarwal, Maha S. Al-Keilani, Zita Sibenaller, Timothy C. Ryken and Mahfoud Assem. NOTCH3: A Potential Predictive Biomarker in Malignant Glioma. Health Sciences Research Week–translational genomics, University of Iowa, IA, 2012.
Desagregando reformas: sindicatos y reformas laborales en izquierdas moderadas

What reforms in labor markets have left­wing governments carried out in recent years? This question is relevant because it allows us to inquire about the Docente e investigador Facultad de Derecho y Facultad de Ciencias Sociales, Universidad de la República. Orcid: 0000­0001­9370­3992 fabricio.carneiro@cienciassociales.edu. uy Doctrina Desagregando reformas: sindicatos y reformas laborales en izquierdas moderadas Fabricio Carneiro Unpacking Reforms: Unions and Labor Reforms in Moderate Lefts Desagregando reformas: sindicatos e reformas trabalhistas nas esquerdas moderadas
Birth Weight of Newborns in Relation to Nutritional Status of Pregnant Women Attending Antenatal Clinic at the Nkawie Government Hospital in Atwima Nwabiagya District, Ghana.

The desire to achieve the Millennium Development Goals 4 and 5 has stimulated several investiga-tions related to pregnancy and birth outcome. Gestational weight gain and haemoglobin levels of pregnant women attending antenatal clinics in the Nkawie Government Hospital were assessed to ascertain their appropriateness, and effect on the birth weight of the newborns. The study was ob-servational and prospective; involving 150 singleton pregnant women aged 15-49 years, in their second trimester, with risk-free pregnancy selected through systematic random sampling. Struc-tured questionnaire and records from maternal health clinics on body weight changes and haemo-globin levels were used for the assessment. Birth weights of babies born to the women were ob-tained from the hospital records. The study period was from July to October, 2012. Mean weight gains during second and third trimesters were 2.2± 2.1kg and 2.9± 2.2kg, respectively, with 91.2% and 95.3%, respectively unable to gain the recommended weight. Mean haemoglobin levels at first, second and third trimesters were 10.4± 1.8g/dl; 6.1± 1.6g/dl; and 9.9± 1g/dl, respectively. Mean birth weight was 2.9± 0.5kg. The respective correlation coefficients and p-values between weight gain during the second and third trimesters of pregnancy and birth weight which were 0.01 (p = 0.69) and 0.02 (p = 0.36) indicating a weak positive correlation. Birth weight is positively corre-lated with gestational haemoglobin levels at first and third trimester and infant birth weight with a correlation coefficient of 0.10 (p= 0.008) and 0.13 (p= 0.004), respectively. In this study, weight gain during the second and third trimester of pregnancy was not associated with birth weight. However, birth weight was associated with maternal haemoglobin levels in the first and third tri-mesters of pregnancy. Intensification of health education efforts to improve maternal nutrition at ANC (Ante natal clinic) is recommended.
Uso de stents farmacolgicos na "vida real": a importncia dos registros

over the last decades the efficacy and safety of bare metal (BMS) and drug eluting stents (DES) have been demonstrated in many different clinical scenarios, leading to their use in more than 75% of the procedures worldwide. Compared to BMS, DES have shown lower rates of angiographic restenosis and target-vessel revascularization. This benefit was initially demonstrated in trials that excluded patients with more complex lesions, such as those with larger or smaller vessels, chronic total occlusions, bifurcation lesions, stent restenosis, long lesions and left main coronary artery disease. This real-world population has been recently evaluated in many registries and meta-analyses that are reviewed herein.
On approximate counting

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. On approximate counting Philippe Flajolet
The role of nutrition in the prevention and treatment of degenerative disease

Much degenerative disease including cancer, diabetes, cardiovascular and rheumatoid disease is now associated with the tissue- and DNA-damaging effects of reactive oxygen species (ROS). Drugs and environmental chemicals exacerbate the formation of ROS and enhance their toxic effects. However, two interrelated biological defence systems protect against the adverse effects of ROS and environmental chemicals. The «antioxidant defence system» of glutathione (GSH), superoxide dismutase, GSH peroxidase, and the antioxidants/radical scavengers, vitamin C, vitamin E and retinoids, protect against ROS; and the «chemical detoxication system» of cytochromes P450, epoxide hydrase, GSH S-transferases, glucuronyl transferases etc., deactivate drugs and environmental chemicals
WHATSAPP UTILISATION AT AN INITIAL TEACHER PREPARATION PROGRAMME AT A UNIVERSITY OF TECHNOLOGY IN SOUTH AFRICA

All universities in South Africa are encouraged to use a Learning Management System such as Blackboard to facilitate blended learning. Despite, the availability of Blackboard at one university of technology in the country, some lecturers and students prefer utilising WhatsApp for teaching and learning. The purpose of this study is to investigate students and lecturers? perspectives about learning and teaching using WhatsApp at a university in South Africa. The study was done using a qualitative case study within an intepretivist paradigm. It was guided by Garrison, Anderson and Archer? s Community of Inquiry as a theoretical framework. Sixteen students and two lecturers who heavily use WhatsApp were purposively selected to participate in semi-structured interviews and focus group discussions. The study found that lecturers use WhatsApp not only for communication purposes, but to foster collaborative learning among students. Although students noted some limitations which they experience when using WhatsApp, they preferred the social media to blackboard. The study concludes that although WhatsApp is response to students? needs, it does not adequately prepare students to graduate with digital literacy skills expected by the Department of Education in the country.