Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigenetyka czerniaka Epigenetics of melanoma

chanizmy wpływające na ekspresję materiału genetycznego, niezmieniające jednak sekwencji nukleotydów DNA. Obejmują one metylację DNA oraz potranslacyjne modyfikacje histonów. Metylacja DNA dotyczy cytozyn zlokalizowanych w wyspach CpG. Pociąga za sobą głównie zmiany w oddziaływaniach z czynnikami wiążącymi DNA. Modyfikacje histonów obejmują acetylację, metylację, fosforylację, ubikwitynację i koniugację z cząsteczkami SUMO (ang. small ubiquitin-like modifier), a głównym ich efektem są zmiany struktury i konformacji chromatyny. Badania wskazują, że mechanizmy epigenetyczne są kluczowe w kancerogenezie wielu nowotworów, w tym czerniaka. Podłoże genetyczne melanoma wciąż kryje wiele tajemnic, a wiedza z zakresu klasycznej genetyki pozwala wyjaśnić jedynie część zachorowań na ten nowotwór. Odkrycia na polu epigenetyki rzucają nowe światło na kancerogenezę czerniaka. W pracy przedstawiono przegląd najnowszych doniesień literaturowych na ten temat.
Losses Loom Longer than Gains: Modeling the Impact of Service Crises on Perceived Service Quality over Time

Service providers sometimes face mass service failures. These problems occur across service industries, ranging from severe Internet outages to major delays for airlines or trains. The literature has not yet addressed the following key question: How do service crises affect perceived service quality (PSQ) over time? To answer this question, the authors introduce a Double-Asymmetric Structural Vector Autoregressive model. It captures not only the short- and long-term effects of objective service performance on PSQ but also the differential effects of service crises versus service restoration. The authors analyze a unique data set from a major European railway company, spanning seven years of monthly observations. During this period, severe winter weather caused dramatic service crises. The authors find that performance losses loom larger than gains in the short run and also have permanent negative effects on PSQ in the long run. Consequently, a crisis followed by a restoration will result in a net negative long-term effect on PSQ. The impact of a crisis also depends on the prior trend in objective service performance.
Compliance to Corporate Governance among Publicly-listed Companies in thePhilippines

In the present corporate world, code of governance plays a major role in assessing a company's strengths and weaknesses. A company which implements a sound corporate code of governance tends to maximize the quality of its assets and enterprise value with respect to its shareholders. Such company also gives the impression of transparency and fairness in dealing to all stakeholders. The study randomly selected and downloaded thirty publicly-listed companies with annual reports in 2012 in the Philippine Stock Exchange (PSE) to answer the research instruments specially developed for the study. The paper used descriptive-quantitative design. Frequency and percentage method and ANOVA were used to determine the significant difference between the independent and dependent variables. The results revealed that companiesâ€™ characteristics have no significant difference and did not influence the level of compliance to corporate governance among the respondents. Nevertheless, most businesses that are publicly-listed have high compliance to the requirements of the Securities of Exchange and Commission (SEC) particularly to the compliance, communication and reportorial processes in order to operate efficiently, to attract potential investors and to disclose information about security risks and associated events to protect the interest of the shareholders.
Numerical Study of Heat Pipes Effects to a 3-Dimensional Room with Driven Ventilation

A Computational Fluid Dynamics (CFD) software package is used to investigate numerically a 3-dimensional rectangular-box room installed with heat pipes heat exchanger (HPHE). Heat pipe heat exchanger utilizing refrigerant by mean of working fluid is installed on top of a room. The air-side heat transfer and the flow pattern of a thermo-siphon heat pipes is studied with a natural driven ventilation of a building. Different opening of the inlet and outlet air where the heat pipe installed are tested with round edges opening as well as sharp edges. The standard RANS K–ε turbulence model is used. Results with different setting of heat pipe and opening characteristic, air flow rate and flow pattern as well as its temperature effects are examined.
Hepatitis C virus infection: A review of the current and future aspects and concerns in Pakistan

Hepatitis C virus (HCV) is the major etiological agent of hepatitis. It infects 200 million people worldwide and 85% of them could develop chronic hepatitis, liver function failure or hepatocellular carcinoma. Hepatitis C is rapidly emerging as a major health problem in developing countries like Pakistan with prevalence rate of 10% and genotype 3a is the most prevalent. Here, approximately 80% of infections proceed to chronic infection and infected blood is the primary route of spread. In Pakistan, about 75% of patents do not receive standard anti HCV therapy (Interferon + Ribavirin) and of the 25% that do receive such treatment, the SVR rate is 60 - 70%. This review is designed to cover the information about the status of HCV in Pakistan with major focus on its prevalence, genotypes, current diagnostic assays, available therapies and treatment outcomes. The present review further emphasizes the need to uncover exact HCV prevalence rate in the country, to develop diagnostic assays based on local genotype, to understand the interaction between HCV genotype 3a genes and cell line genes responsible HCV pathogenesis. In addition, this review discusses the need for the generation of infectious pseudo particle of HCV as a potential vaccine, to investigate DNA base vaccine, or siRNA-based anti HCV approaches for our local genotypes. Key words: Hepatitis C, prevalence, genotypes, treatment, Pakistan.
The Einstein Equations on the 3-BRANE World:. a Window to Extra Dimensions

We carefully investigate the gravitational equations of the brane world, in which all the matter forces except gravity are confined on the 3-brane in a 5-dimensional spacetime with $Z_2$ symmetry. We derive the effective gravitational equations on the brane, which reduce to the conventional Einstein equations in the low energy limit. {}From our general argument we conclude that the first Randall & Sundrum-type theory (RS1) [hep-ph/9905221] predicts that the brane with the negative tension is an anti-gravity world and hence should be excluded from the physical point of view. Their second-type theory (RS2) [hep-th/9906064] where the brane has the positive tension provides the correct signature of gravity. In this latter case, if the bulk spacetime is exactly anti-de Sitter, generically the matter on the brane is required to be spatially homogeneous because of the Bianchi identities. By allowing deviations from anti-de Sitter in the bulk, the situation will be relaxed and the Bianchi identities give just the relation between the Weyl tensor and the energy momentum tensor. In the present brane world scenario, the effective Einstein equations cease to be valid during an era when the cosmological constant on the brane is not well-defined, such as in the case of the matter dominated by the potential energy of the scalar field.
Assessment of genetic variability, morphology and productivity response of Vicia faba under the stress of lead nitrate

Introduction Heavy metals are the most toxic and environmentally harmful pollutants and due to its rapid growth environmental pollution is increasing. It is second ranked chemical of all hazardous substances by the Agency for Toxic Substances and Disease Registry (ATSDR, 2007). Heavy metals like Lead, Cadmium, Copper and Mercury are the most abundant which contribute to the growing pollution problem. Industrialization and rapid urbanization have increased the level of toxic heavy metal in an environment, which affect health hazard for all living organisms (Lewis et al., 1989). A number of authors have discussed and determined the relationships of heavy metals in natural and industrial environments, the increased frequency of chromosome mutations, and the cancerous processes in organisms. The heavy metal at higher concentration usually causes anomalies in mitotic division. Lead inhibits spindle formation and shows a c-mitotic effect. When plants exposed to lead nitrate even at low concentration, usually experience harmful effects such as micronucleus induction (National Toxicology Program, 2003), mitosis disturbance (Wierzbicka, 1999), DNA damage (Gichner et al., 2008), alterations in membrane permeability (Sharma and Dubey, 2005) and disturbance (inhibition or activation) of enzymatic activities (Reddy et al., 2005) along with various physiological impacts. Abstract The objectives of present study was designed to determine the mutagenic effects of lead on cytomorphology of Vicia faba and to determine the maximum concentration of lead nitrate that induce maximum genetic variability. The seeds of Vicia were treated with five different concentrations (20, 40, 60, 80, 100 ppm) of lead nitrate. The quantitative traits viz. plant height, number of branches per plant, number of pods per plant, pollen fertility, and yield were significantly reduced by higher concentrations of lead nitrate. Higher concentration also caused the variation in seedling and mature stages. Different type of meiotic abnormalities such as laggard, bridge, precocious separation, disturb polarity, micronuclei, sticky metaphase, stray bivalent were recorded. The percentage of abnormalities increased with the lead nitrate concentration. On the basis of these results, it was concluded that the lower concentration of lead did not affect significantly on the cytomorphology of Vicia faba while higher concentrations of lead nitrate were found to be more effective and cytotoxic.
A pr 2 00 5 Lossy data compression with random gates

We introduce a new protocol for a lossy data compression algorithm which is based on constraint satisfaction gates. We show that the theoretical capacity of algorithms built from standard paritycheck gates converges exponentially fast to the Shannon’s bound when the number of variables seen by each gate increases. We then generalize this approach by introducing random gates. They have theoretical performances nearly as good as parity checks, but they offer the great advantage that the encoding can be done in linear time using the Survey Inspired Decimation algorithm, a powerful algorithm for constraint satisfaction problems derived from statistical physics.
Elderly’s Physical-Functional Fitness and Perceived Functional Capacity and Health after Participation in a Hydrotherapy Program

Several studies have demonstrated how physical activity in older people benefits their physical fitness, health and well-being. The relation between physical activity and perceived functional capacity and health is yet to be considered. This study is a quantitative research design that investigated the improvement of the physical-functional fitness and the perception of the functional capacity and health of an elderly group participating in a water-based exercise program (hydrotherapy). The data was collected in three different moments of the exercise program through a battery of tests of physical-functional fitness established by Batista and Sardinha (2005) and a questionnaire adapted from SABE project (Lebrao and Duarte, 2003). Twenty-six elderly persons (23 women and 3 men) aged between 60 and 84 years old participated in a 31-week hydrotherapy program (twice a week; 45 minutes by session). Friedman test was used for assessing statistical differences between the physical-functional fitness and the questionnaire responses in each of the three evaluation moments. Results revealed that this program was enough to improve the physical-functional fitness of the elderly, as well as the perception they had about their health and ability to perform activities of daily living.
Parameter Estimation of Heavy-Tailed AR Model With Missing Data Via Stochastic EM

The autoregressive (AR) model is a widely used model to understand time series data. Traditionally, the innovation noise of the AR is modeled as Gaussian. However, many time series applications, for example, financial time series data, are non-Gaussian, therefore, the AR model with more general heavy-tailed innovations is preferred. Another issue that frequently occurs in time series is missing values due to system data record failure or unexpected data loss. Although there are numerous works about Gaussian AR time series with missing values, as far as we know, there does not exist any work addressing the issue of missing data for the heavy-tailed AR model. In this paper, we consider this issue for the first time, and propose an efficient framework for parameter estimation from incomplete heavy-tailed time series based on a stochastic approximation expectation maximization coupled with a Markov Chain Monte Carlo procedure. The proposed algorithm is computationally cheap and easy to implement. The convergence of the proposed algorithm to a stationary point of the observed data likelihood is rigorously proved. Extensive simulations and real datasets analyses demonstrate the efficacy of the proposed framework.
Testing APT Model upon a BVB Stocksâ€™ Portfolio

Applying the Arbitrage Pricing Theory model (APT), there can be identified the major factors of influence for a BVBâ€™ portfolio stocksâ€™ trend. There were taken into consideration two of the APT theory models, establishing influences upon portfolioâ€™s yield: given to macroeconomic environment and to some stochastic factors. The researchâ€™s results certify that, on the long term, what influences the stocksâ€™ movement in the stock market is mostly the action of specific short-term factors, without general covering, like the ones that are classified in the research area of behavioral finance (investorsâ€™ preference towards risk and towards time).
Recursive Route to Mixed Poisson Distributions using Integration by Parts

Mixed Poisson distributions are very significant in modeling non-homogeneous populations; for instance in Actuarial applications for modeling total claims in insurance. However, the setback is in their use since the probability mass functions are difficult to evaluate, except for a few mixing distributions. One way of dealing with this problem is to express Mixed Poisson distributions in terms of recursive relations. In this paper, recursive relations of some mixed Poisson distributions are obtained by use of integration by parts technique. Keywords: mixtures; recursive relation; generating functions; moments
Characteristics of Distributed Generation System and Related Research Issues Caused by Connecting It to Power System

The characteristics of distributed generation(DG) system are presented in brief.In three aspects,i.e.,the construction period and operation period of power grid containing DG and under the situation that accidents occur in the power grid containing DG,some problems caused by connecting DG to power grid and related research issues are discussed.The problems and issues are as following:when the proportion of DG in the planning scheme increases,the complexity of power grid evidently raises,and connecting DG to power grid brings the influences in the structure of distribution system,load forecasting,site selection of substations and so on;during the operation of the power grid,DG influences on intrinsic frequency,power flow,voltage oscillation and high-order harmonics of the power grid;the features of power grid containing DG find expression in island effect,system reliability and short-circuit capacity while accidents occur.Present research situation of above-mentioned issues and the direction in the research are expounded.
Contextualizing the Informed Consent Process in Vaccine Trials in Developing Countries

Introduction: Most sponsors of clinical trials in Africa propose the use of complicated informed consenting procedures as in developed countries, including the translation of informed consent forms into local languages. Although well intentioned, this practice may be irrelevant and of no added value in settings where local languages are only spoken but not written. Recognizing this challenge, the ethics committee in The Gambia recommend a consent procedure that takes into account these local realities. The objective of this paper was to assess the effectiveness of this new procedure in conveying key trial information among participants in a vaccine trial in The Gambia. Methods: Consent was obtained from 1200 parents using the new procedure. Comprehension was then assessed using a tool that contained questions on key aspects of the trial. Results: Although the majority of respondents had no formal education, almost all of them had a sound understanding of the trial. Variables such as age, gender, education, ethnicity and occupation had minimal effect on comprehension. Discussion and Conclusion: Our data suggest that the new consent procedure is effective in conveying key research information to research participants. The procedure is promising in that it has eliminated the need for repeatedly translating and back-translating informed consents. It also guarantees that the study team expresses research concepts in the same way.
CLARA GIFRE OLIVERAS ADAPTIVE MOTION PLANNING FOR A MOBILE ROBOT

Historically, trapezoidal velocity profiles have been widely used to control engines. Nevertheless, the evolution of robots and their uses has led to the need of using smoother profiles, due to the demand of high precision and delicate movements. It has been shown that this can be achieved by minimizing the change of acceleration and using s-curve profiles. Moreover, to provide a good control of the movement of a robot, it is necessary to ensure that it will meet the desired velocity profile. Therefore, a way to prevent how the wheels will react on the soil becomes highly useful, in order to adapt the supplied torque. This thesis suggests a model to define an appropriate s-curve velocity profile given the desired starting and ending kinematic states for a mobile robot. The study is then focused on a one-wheel system to define the interaction between the soil and a wheel. This interaction is modelled and extended in order to calculate the required torque, drawbar pull and power needed to fulfil the desired s-curve velocity profile. Finally, an introduction to unicycle robots is given as an example of how the proposed models could be applied in the motion planning of a mobile robot.
Nonisospectral Flows on Semi-infinite Jacobi Matrices

It is proved that if the spectrum and spectral measure of a semi-infinite Jacobi matrix L(t) change appropriately, then L(t) satisfies a generalized Lax equation of the form ˙ L(t) = ( L(t),t)+[L(t),A(L(t),t)], where ( ,t ) is a polynomial with t-dependent coecients and A(L(t),t) is a skew-symmetric matrix which is determined by the evolution of the spectral data. Such an equation is equivalent to a wide class of generalized Toda lattices. The theory of Jacobi matrices gives rise to the procedure of solution of the corresponding Cauchy problem by the inverse spectral problem method. The linearization of this nonlinear equation in terms of the moments is established.
On Counting the Poor in a Multidimensional Context

We claim here that, in the context of multidimensional poverty measurement, de…ning the set of the poor independently on the poverty measure yields nonsensical results and implies a violation of some basic properties. We show that an index that satis…es montonicity, focus, and restricted continuity, de…nes endogeonously the set of the poor as the set of agents for which the index shows the presence of poverty when considered as a society of a single individual.
FACTORS OF EFFECTIVENESS OF EUROPEAN INNOVATION PARTNERSHIP IN AGRICULTURE

The European Innovation Partnership (EIP) is considered to be a new phenomenon signalling political will, highly relevant issue in contemporary domain of discussions among practitioners and researchers. While practitioners lack experience, researchers make attempts to identify the factors that influence effectiveness of an innovation partnership, explore the indicators and techniques to determine and evaluate its effectiveness. Aim of the study presented in the article is to determine the external and internal factors that influence effectiveness of the European Innovation Partnership by analysing the operating conditions of an operational group of the European Innovation Partnership in Agriculture (EIP-AGRI). Expert evaluation was carried out by experts who have scientific and practical experience: scientists, policy makers, innovators, developing an innovation partnership. The force field analysis has shown that the number of negative factors of EIP effectiveness exceeds the number of positive factors, and the factors analysed and evaluated allow to identify potential negative consequences in a timely manner and provide the opportunity to predict effectiveness of the EIP-based projects.
Individual differences in the use of visual-perception information to guide weight transfer and bat movements in elite cricket batting

Early pick-up of visual information is vital for success in high-speed striking sports such as cricket batting. Expert performers are more adept at utilising visual information to anticipate and guide motor skill action than lesser-skilled performers. Research in sport expertise has compared the capability to use visual information to guide motor skill action between groups of experts and groups of less skilled performers, whilst sport biomechanics has focused on motor skill execution. Little is known about individual differences within experts groups and the capability to use visual information to guide biomechanical action variables in striking skills. The purpose of this master’s thesis was (a) to provide a critical review of literature in a position statement that would assist the implementation of perception-action coupled representative task experiments, and (b) advance existing sports science literature by combining sport expertise and sport biomechanics methodologies in an attempt to identify individual differences within an expert group of cricket batsmen. Eight expert cricket batsmen from the Western Australian Cricket Association High Performance Squad were tested on their capability to utilise early visual information to guide the timing of weight transfer (kinetics) and bat movement (kinematics) in an in-situ temporal occlusion batting task. Comparisons revealed there were some significant differences between batsmen for measures of initiation of weight transfer, initiation of bat downswing and duration of bat downswing. There was, however, no significant difference between batsmen in the completion of weight transfer measure. After comparing quality of interception, no significant difference was found between batsmen, indicating different movement patterns may be used to achieve the same outcome, a concept known as motor equivalence. These findings have extended both theoretical and applied knowledge of understanding expertise in striking sports, which may be useful for other sports.