Miracle-dz/UniFAR-FTUs huggingface dataset:
KINECT 3: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Valbenazine for Tardive Dyskinesia.

OBJECTIVE Tardive dyskinesia is a persistent movement disorder induced by dopamine receptor blockers, including antipsychotics. Valbenazine (NBI-98854) is a novel, highly selective vesicular monoamine transporter 2 inhibitor that demonstrated favorable efficacy and tolerability in the treatment of tardive dyskinesia in phase 2 studies. This phase 3 study further evaluated the efficacy, safety, and tolerability of valbenazine as a treatment for tardive dyskinesia. METHOD This 6-week, randomized, double-blind, placebo-controlled trial included patients with schizophrenia, schizoaffective disorder, or a mood disorder who had moderate or severe tardive dyskinesia. Participants were randomly assigned in a 1:1:1 ratio to once-daily placebo, valbenazine at 40 mg/day, or valbenazine at 80 mg/day. The primary efficacy endpoint was change from baseline to week 6 in the 80 mg/day group compared with the placebo group on the Abnormal Involuntary Movement Scale (AIMS) dyskinesia score (items 1-7), as assessed by blinded central AIMS video raters. Safety assessments included adverse event monitoring, laboratory tests, ECG, and psychiatric measures. RESULTS The intent-to-treat population included 225 participants, of whom 205 completed the study. Approximately 65% of participants had schizophrenia or schizoaffective disorder, and 85.5% were receiving concomitant antipsychotics. Least squares mean change from baseline to week 6 in AIMS dyskinesia score was -3.2 for the 80 mg/day group, compared with -0.1 for the placebo group, a significant difference. AIMS dyskinesia score was also reduced in the 40 mg/day group (-1.9 compared with -0.1). The incidence of adverse events was consistent with previous studies. CONCLUSIONS Once-daily valbenazine significantly improved tardive dyskinesia in participants with underlying schizophrenia, schizoaffective disorder, or mood disorder. Valbenazine was generally well tolerated, and psychiatric status remained stable. Longer trials are necessary to understand the long-term effects of valbenazine in patients with tardive dyskinesia.
The Bradyrhizobium japonicum Irr Protein Is a Transcriptional Repressor with High-Affinity DNA-Binding Activity

ABSTRACT The Irr protein is a global regulator of iron homeostasis in Bradyrhizobium japonicum, and a subset of genes within the Irr regulon are negatively controlled under iron limitation. However, repressor function, high-affinity DNA binding in vitro, or promoter occupancy in vivo of Irr for a negatively regulated gene has not been demonstrated. Here, we show that the blr7895 and bll6680 genes are negatively regulated by Irr as determined by derepression of transcript levels in iron-limited cells of an irr mutant strain. Electrophoretic gel mobility shift analysis showed that a component in extracts of wild-type cells grown under iron limitation bound the iron control elements (ICE) within the promoters of blr7895 and bll6680 identified previously (G. Rudolph, G. Semini, F. Hauser, A. Lindemann, M. Friberg, H. Hennecke, and H. M. Fischer, J. Bacteriol. 188:733-744, 2006). Binding was not observed with extracts of cells from the parent strain grown under high iron conditions or with those from an irr mutant. Furthermore, gel mobility supershift experiments identified Irr as a component of the binding complex. Purified recombinant Irr bound to ICE DNA with high affinity in the presence of divalent metal, with K d values of 7 to 19 nM, consistent with a physiological role for Irr as a transcriptional regulator. In addition, in vitro transcription initiated from the blr7895 promoter was inhibited by Irr. Whole-cell cross-linking and immunoprecipitation experiments showed that Irr occupies the promoters of blr7895 and bll6680 in vivo in an iron-dependent manner. The findings demonstrate that Irr is a transcriptional repressor that binds DNA with high affinity.
Computerized surveillance of adverse drug events in hospital patients*

Objective: To develop a new method to improve the detection and characterization of adverse drug events (ADEs) in hospital patients. Design: Prospective study of all patients admitted to our hospital over an 18 month period. Setting: LDS Hospital, Salt Lake City, Utah, a 520-bed tertiary care center affiliated with the University of Utah School of Medicine, Salt Lake City. Patients: We developed a computerized ADE monitor, and computer programs were written using an integrated hospital information system to allow for multiple source detection of potential ADEs occurring in hospital patients. Signals of potential ADEs, both voluntary and automated, included sudden medication stop orders, antidote ordering, and certain abnormal laboratory values. Each day a list of all potential ADEs from these sources was generated, and a pharmacist reviewed the medical records of all patients with possible ADEs for accuracy and causality. Verified ADEs were characterized as mild, moderate, or severe and as type A (dose-dependent or predictable) or type B (idiosyncratic or allergic) reactions, and causality was further measured using a standardized scoring method. Outcome measure: The number and characterization of ADEs detected. Results: Over 18 months we monitored 36 653 hospitalized patients. There were 731 verified ADEs identified in 648 patients, 701 ADEs were characterized as moderate or severe, and 664 were classified as type A reactions. During this same period only nine ADEs were identified using traditional detection methods. Physicians, pharmacists, and nurses voluntarily reported 92 of the 731 ADEs detected using this automated system. The other 631 ADEs were detected from automated signals, the most common of which were diphenhydramine hydrochloride and naloxone hydrochloride use, high serum drug levels, leukopenia, and the use of phytonadione and antidiarrheals. The most common symptoms and signs were pruritus, nausea and/or vomiting, rash, and confusion-lethargy. The most common drug classes involved were analgesics, anti-infectives, and cardiovascular agents. Conclusion: We believe that screening for ADEs with a computerized hospital information system offers a potential method for improving the detection and characterization of these events in hospital patients.
Performance Analysis of Equal Gain Transmission Technique for SC-FDMA System

The long term evolution (LTE) standard for uplink transmission is based on single carrier frequency division multiple access (SC-FDMA) maintaining low peak-to-average power ratio (PAPR), which is very valuable for the practical handset design. Recently the usage of codebook-based precoding has been thoroughly discussed for the LTE-Advanced (LTE-A) uplink. Among the various precoding schemes, equal gain transmission (EGT) is proposed in this paper because it does not increase any PAPR. Especially, considering a nonlinear transmit power amplifier model in the uplink, EGT is superior to any other precoding schemes. Theoretical analysis of precoding schemes' PAPR is presented under a quasi-static flat fading channel, and link-level bit error rate (BER) is simulated to corroborate the anticipated results.
L’étude du traitement des relations spatiales visuelles : approche dynamique des capacités cognitives

Le modele computo-fonctionnel de la vision de haut niveau de Kosslyn et Koenig (1992) repose sur la dissociation entre la reconnaissance et le traitement spatial de la scene visuelle. En 1987, Kosslyn postula l’existence de deux processus pour le traitement des relations spatiales : un processus categoriel qui calcule les positions relatives des objets et un processus coordonne qui calcule la distance entre les objets. Des etudes utilisant le paradigme de presentation en champ visuel divise ont mis en evidence que l’hemisphere gauche sous-tendrait un traitement categoriel ; l’hemisphere droit sous-tendrait un traitement coordonne. Cette interaction semblerait valider la dichotomie des deux types de processus.Une revue de la litterature pluridisciplinaire a ete menee afin de savoir si ce fait est suffisant pour rejeter l’hypothese d’un processus unique pour les traitements categoriels et coordonnes. Entre autres, plusieurs etudes ont observe un effet de pratique au cours de la realisation de jugements coordonnes : une diminution de l’intervention de l’hemisphere droit au profit d’une prise en charge progressive de l’hemisphere gauche. De plus, l’avantage de l’hemisphere gauche pour le traitement categoriel a ete rarement observe.Une serie de cinq experiences comportementales ont ete conduites pour verifier certains biais experimentaux qui pourraient expliquer les differences hemispheriques et l’effet de pratique observes. Nos resultats nous ont permis d’avancer des hypotheses axees sur la communication entre les hemispheres et sur un lien entre les processus categoriels et coordonnes. Une critique du paradigme de presentation en champ visuel divise et differents modeles d’interaction hemispherique ont ete presentes. Trois experiences ont ete menees, afin d’evaluer l’impact des communications hemispheriques dans le traitement des relations spatiales. A la lumiere de nos resultats, la dichotomie des processus categoriels et coordonnes a ete discutee.
Absolving Beta of Volatility's Effects

The beta anomaly, negative (positive) alpha on stocks with high (low) beta, arises from beta’s positive correlation with idiosyncratic volatility (IVOL). The relation between IVOL and alpha is positive among underpriced stocks but negative and stronger among overpriced stocks (Stambaugh, Yu, and Yuan, 2015). That stronger negative relation combines with the positive IVOL-beta correlation to produce the beta anomaly. The anomaly is significant only within overpriced stocks and only in periods when the beta-IVOL correlation and the likelihood of overpricing are simultaneously high. Either controlling for IVOL or simply excluding overpriced stocks with high IVOL renders the beta anomaly insignificant.
Human oriented performance management: Is there a gap between executives and non-executives?

For organizations it is important to translate the strategy and goals of the organization in tangible targets for the employees. Often, this leads to many Key Performance Indicators (KPI) for the employees. However, the link between their personal KPI’s and the goals of the organization is not always recognised. Therefore, based on previous research into performance management and on theories of organizational behaviour, culture and performance a model was developed to measure human oriented performance management in organizations. Human oriented performance management is all about establishing a direct connection between the objectives and strategy of an organization (or part thereof) and the activities and tasks of the people in the different processes. The research question in this paper is to what extent the dimensions of human oriented performance management do occur within organizations and how these
Traduction compositionnelle automatique de bitermes dans des corpus anglais/français alignés

Le Catalogue et Index des Sites Medicaux Francophones (CISMeF) recense les principales ressources institutionnelles de sante en francais. La description de ces ressources, puis leur acces par les utilisateurs, se fait grâce a la terminologie CISMeF, fondee sur le thesaurus americain Medical Subject Headings (MeSH). La version francaise du MeSH comprend tous les descripteurs MeSH, mais de nombreux synonymes americains restent a traduire. Afin d’enrichir la terminologie, nous avons mis en œuvre une methode de traduction compositionnelle automatique des synonymes. Pour ce faire, nous avons constitue deux corpus alignes anglais/francais du domaine medical puis nous avons procede automatiquement a l’appariement bilingue de mots et a la traduction compositionnelle des bitermes de type Adj N. La technique d’appariement de mots utilisee est basee sur une analyse syntaxique de corpus alignes. 915 synonymes distincts de type Adj N ont pu etre traduits, avec une precision globale de 73%, moyennant une selection des traductions des composants au rang 1.
Enterobacter sakazakii infection in the newborn

Enterobacter sakazakii, a Gram‐negative bacillus, previously known as “yellow pigmented Enterobacter cloacae,” is a rare cause of neonatal infection. We describe the detailed clinical presentation of two cases in whom E. sakazakii was isolated in our neonatal service during the course of 1 mo. These include one case of sepsis and meningitis complicated by cerebral infarction, and one case of sepsis. In addition, three cases of intestinal colonization were identified. The source of the organism was thoroughly sought and was found to be a blender in the milk kitchen that was used for preparation of the reconstituted powdered milk formula.
Comparing consumer-directed and agency models for providing supportive services at home.

OBJECTIVE To examine the service experiences and outcomes of low-income Medicaid beneficiaries with disabilities under two different models for organizing home-based personal assistance services: agency-directed and consumer-directed. DATA SOURCE A survey of a random sample of 1,095 clients, age 18 and over, who receive services in California's In-Home Supportive Services (IHSS) program funded primarily by Medicaid. Other data were obtained from the California Management and Payrolling System (CMIPS). STUDY DESIGN The sample was stratified by service model (agency-directed or consumer-directed), client age (over or under age 65), and severity. Data were collected on client demographics, condition/functional status, and supportive service experience. Outcome measures were developed in three areas: safety, unmet need, and service satisfaction. Factor analysis was used to reduce multiple outcome measures to nine dimensions. Multiple regression analysis was used to assess the effect of service model on each outcome dimension, taking into account the client-provider relationship, client demographics, and case mix. DATA COLLECTION Recipients of IHSS services as of mid-1996 were interviewed by telephone. The survey was conducted in late 1996 and early 1997. PRINCIPAL FINDINGS On various outcomes, recipients in the consumer-directed model report more positive outcomes than those in the agency model, or they report no difference. Statistically significant differences emerge on recipient safety, unmet needs, and service satisfaction. A family member present as a paid provider is also associated with more positive reported outcomes within the consumer-directed model, but model differences persist even when this is taken into account. Although both models have strengths and weaknesses, from a recipient perspective the consumer-directed model is associated with more positive outcomes. CONCLUSIONS Although health professionals have expressed concerns about the capacity of consumer direction to assure quality, particularly with respect to safety, meeting unmet needs, and technical quality, our findings suggest that the consumer-directed service model is a viable alternative to the agency model. Because public programs are under growing pressure to address the long-term care needs of low-income people of all ages with disabilities, the Medicaid personal assistance benefit needs to be reassessed in light of these findings. Consumer-directed models may offer a less elaborate and possibly less costly option for organizing supportive services at home. Study limitations may limit the generalizability of these findings. This was a natural experiment, in which only some counties offered both service models and counties assigned recipients to a service model. The use of a telephone survey excluded important recipient subsets, notably people with severe cognitive impairments. A more definitive study would include direct observations as well as survey approaches.
Kalman filtering algorithm for blind source separation

The paper presents a Kalman filtering algorithm based on nonlinear principal component analysis (PCA) with prewhitening for blind source separation (BSS), and compares the new algorithm with other algorithms. Simulations show that, for BSS, the Kalman filtering algorithm has a faster convergence rate and a much better tracking capability, compared with the existing natural gradient algorithm for independent component analysis (ICA), the RLS algorithm and the natural gradient based RLS-type algorithm for nonlinear PCA.
Beaming signal sources in measurement of focal visual evoked cortical potentials

VECPs (visual evoked cortical potential) after focal stimulation used in perimetry have weak amplitudes in comparison to the spontaneous EEG, thus the SNR (signal-to-noise ratio) falls off down to -20 dB and less. The shape of the VECP waves depends on several parameters and is unknown in general. Then for SNR enhancement and signal detection shape-independent methods can be used only. The most common of them is the stimulus synchronized averaging, which causes cumulative prolongation of the measurement time corresponding to the averaging order. For online measurements of VECP other ways in signal improvement are needed. In this paper a new method for SNR enhancement based on beam forming is introduced. While the anatomical structures of sources generating the focal VECP are known roughly and the electrode positions have sufficient density over the visual cortex, signal sources can be focused by controlling the channel delay.
AMERICAN METEOROLOGICAL SOCIETY

The American Meteorological Society (AMS) recognizes that the House Committee on Science, Space, and Technology has oversight responsibilities with respect to NOAA and other federal agencies with a science mission. AMS also recognizes that given the concerns raised publicly by John Bates concerning what you have referred to as " the Karl study, " the Committee may feel obligated to pursue further investigation. Despite that, AMS continues to have concerns that seeking the full range of deliberative discussions among the NOAA scientists involved in this research could have a chilling effect that would negatively impact the science conducted throughout government agencies. Science often depends on robust discussions among colleagues that include frank criticisms, frequently offered using shorthand language that is well-understood within the community but that may be easily misinterpreted by others if taken out of context. If scientists within an agency feel they cannot have those sorts of candid discussions through written correspondence without fear of possible misinterpretation, they may choose to avoid these deliberative discussions altogether, with the science suffering as a result. Again, with sensitivity toward the legitimate oversight responsibilities of the House Committee, AMS hopes the Committee and NOAA can find ways to investigate concerns that do not put undue burden on NOAA scientists and that preserve the ability of NOAA and other agency scientists to have internal deliberative discussions without fear of repercussions. Perhaps more importantly, AMS would like to use this opportunity to point out that with respect to the Karl et al. study, there is every indication that the scientific process has worked exactly as it should. In addition to publication of the paper in Science following what appears to have been a lengthy and rigorous peer review, the data and methodologies used for the work were made fully available to the community. Given the impact of the results, other scientific groups have carried out independent analyses and published their own results, some that questioned the conclusions of the Karl et al. paper and others that have independently reached similar conclusions. As noted in a 2013 statement of the AMS 1 : Science is always based on observations and experimentation. Scientists insist on disclosure of hypotheses, observations, methods, and interpretation of the results through a process known as peer review, which provides other scientists an opportunity to evaluate their methods and the logic that led to their conclusions. A published result may not …
Vasoactive amines modulate actin cables (stress fibers) and surface area in cultured bovine endothelium

Cultured bovine aortic endothelial cells were fixed and stained with NBD‐phallicidin and quantitated with a digital image analyzer for changes in actin cables and surface area. Serotonin (5‐HT), norepinephrine (NE), dopamine and histamine (all at 10−4M concentrations) were tested for their ability to induce cytoskeletal changes. Only 5‐HT and NE increased action cables significantly (p < 0.01), 80.7% and 97.9%, respectively. Dopamine and histamine treated cells showed a 67.4% and 80.8% decrease in actin cables respectively (p < 0.01). Stimulated increases of actin cables by 5‐HT were inhibited by Ketanserin, and propranoiol inhibited NE stimulation of actin cables. Treatment of cells with these blockers alone also decreased actin cables below control values (p < 0.01). Pretreatment of cells with diphenhydramine, but not cimetidine, inhibited histamine‐induced decreases in actin cables. Stimulation of surface area by 5‐HT and NE was also observed, with 40.8% and 80.7% increases respectively, when compared with controls (p < 0.01). The increases in actin cables were associated with a lack of ruffled edges that are indicative of motile cells. In contrast, induced decreases in actin cables resulted in cells with ruffled edges. Exogenous 5‐HT and NE have been shown to prevent the increased permeability visible as extravasation of red blood cells from postcapillary venules in thrombocytopenic animals. The present data suggest that 5‐HT and NE may be involved in maintaining the endothelial barrier function by a receptor‐mediated stimulation of actin cables. Also, histamine‐induced decreases in actin cables may be correlated with the amine's action in vivo as a mediator of increased inflammatory permeability.
Human embryonic stem cells and cardiac cell fate

Human embryonic stem (HES) cells are pluripotent and give rise to any cell lineage. More specifically, how the first embryonic lineage (i.e., cardiac lineage) is acquired remains in many aspects questionable. Herein, we summarize the protocols that have been used to direct the fate of HES cells toward the cardiomyocytic lineage. We further discuss the regulation of transcriptional pathways underlying this process of differentiation. Finally, we propose perspectives of this research in the near future. J. Cell. Physiol. 218: 455–459, 2009. © 2008 Wiley‐Liss, Inc.
Chromosome 7q: where autism meets language disorder?

On the basis of evidence from twin and family studies, both autism and developmental language disorder—also referred to as specific language impairment (SLI)—are believed to be genetically mediated. The genetic mechanisms involved, however, are not clear. For example, the prevalence of autism is currently estimated at 1/1,000 (Fombonne 1999), whereas the recurrence risk in families is 6%–8% (Santangelo and Folstein 1999). On the basis of combined data from three population-based twin studies, the concordance rate for MZ twins is estimated to be ∼65%, contrasted with a concordance rate of 0% in DZ twins (Bailey et al. 1995). Presumably, the DZ rate of 0% is a type II error, since the combined samples contain . 90, and there is no convincing evidence for perinatal or other environmental risk factors. Genetic modeling based on these data has been consistent with a model of oligogenic inheritance with epistasis (Pickles et al. 1995).