Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapists' Emotional Reactions to Anxious Inpatients During Integrated Behavioral-Psychodynamic Treatment: A Psychometric Evaluation of a Feeling Word Checklist

The purpose of this study was to examine the factor structure of a feeling checklist purported to measure therapists' emotional reactions to their patients, and to evaluate psychometrically the factor-based scales. Therapists completed the checklist after both a behavioral and a psychodynamic phase of a treatment program for inpatients with panic disorder, agoraphobia, and other phobic disorders. The results of factor analysis revealed three distinct dimensions: interest-boredom, insecurity-security, and anger. The corresponding three subscales proved to have a satisfactory internal consistency, and they correlated strongly with their respective factors. The criterion-oriented validity of the insecurity and anger subscales was supported by their ability to differentiate between completers and noncompleters of the program. The three subscales correlated poorly with DSM-III-R personality disorder indices. More subjectively experienced interest and less subjectively experienced anger on the part of the therapists toward patients were related to a stronger reduction in the patients' avoidance behavior in the one-year follow-up period.
Survey of Susceptibilities to Monosultap, Triazophos, Fipronil, and Abamectin in Chilo suppressalis (Lepidoptera: Crambidae)

Abstract To provide a foundation for national resistance management of the Asiatic rice borer, Chilo suppressalis (Walker) (Lepidoptera: Crambidae), a study was carried out to determine dose-response and susceptibility changes over a 5-yr period in the insect from representative rice, Oryza sativa L. , production regions. In total, 11 populations were collected from 2002 to 2006 in seven rice-growing provinces in China, and they were used to examine their susceptibility levels to monosultap, triazophos, fipronil, and abamectin. Results indicated that most populations had increased tolerance to monosultap. Several field populations, especially those in the southeastern Zhejiang Province, were highly or extremely highly resistant to triazophos (resistance ratio [RR] = 52.57–899.93-fold), and some populations in Anhui, Jiangsu, Shanghai, and the northern rice regions were susceptible or had a low level of resistance to triazophos (RR = 1.00–10.69). Results also showed that most field populations were susceptible to fipronil (RR < 3), but the populations from Ruian and Cangnan, Zhejiang, in 2006 showed moderate levels of resistance to fipronil (RR = 20.99–25.35). All 11 field populations collected in 2002–2006 were susceptible to abamectin (RR < 5). The tolerance levels in the rice stem borer exhibited an increasing trend (or with fluctuation) over a 5-yr period for different insecticides, and they reached a maximal level in 2006 for all four insecticides. Analysis of regional resistance ratios indicated that the history and intensity of insecticide application are the major driving forces for the resistance evolution in C. suppressalis. Strategic development of insecticide resistance management also is proposed.
A Role for Stem Cell Biology in the Physiological and Pathological Aspects of Aging

The stem cell is an essential component of a developmental phenomenon—one of the key components of a program fundamental to organogenesis and the maintenance of homeostasis throughout life. The stem cell confers plasticity to the process. Because aging is part of the developmental arc, an understanding of the stem cell is essential to understanding aging and some of the degenerative conditions that accompany it. Because stem cells may be isolated and manipulated ex vivo and then reimplanted into organs, they may serve a variety of functions. They have the capability of migrating long distances and targeting pathological conditions, of expressing therapeutic genes and responding to cues that shift their differentiation toward deficient lineages. Therefore, stem cells may be used for cell replacement, for therapeutic interventions, and potentially to modify aging.
Medical tool tracking in fluoroscopic interventions: new insights in detection and tracking of tubular tools

These days, fluoroscopic imaging is the modality used most widely to guide physicians during minimally invasive abdominal interventions. They involve transarterial chemoembolization for hepatocellular carcinoma, the placement of transjugular intrahepatic portosystemic shunts or needle aspiration of solitary lung nodules, to name a few. These kinds of interventions share the task of navigating a surgical tool to a specific anatomical site. Difficulties for the physicians arise from the fact that fluoroscopy, a two-dimensional modality, is used to support an actually three-dimensional navigation task. Thus, enhanced navigation procedures incorporating three-dimensional data are desired for fluoroscopic interventions. Not only should they improve the navigation but also offer the potential to reduce treatment time and radiation exposure for the patient as well as the physician. Due to the complexity of such a system and despite previous efforts, an integrated solution does not yet exist. Localization of medical tools and the estimation of their motion are core components of such a navigation system and this work focuses on related methods to improve the detection and tracking during fluoroscopic interventions. To this end, different image enhancement algorithms required for the tool localization are reviewed and analyzed in a unified framework. Based on the analysis a fast and robust localization scheme is developed. Furthermore, a novel method for tracking the tools in a non-rigid environment is introduced. The tracking algorithm is based on discrete optimization and thus it is derivative free and can deal with complex models. It is fast and robust and hence complying with application specific constraints. Moreover, the presented tracking method is generic and can be extended to closed curves, which makes it applicable to other problems such as segmentation. Based on the results, a novel respiratory motion estimation procedure is developed. It is the basis for the creation of a navigation system and is essential in order to establish the relation between the location of medical tools and three-dimensional data used for the actual navigation.
Differentiation Between Classic and Atypical Meningiomas with Use of Diffusion Tensor Imaging

BACKGROUND AND PURPOSE:The differentiation between classic and atypical meningiomas may have implications in preoperative planning but may not be possible on the basis of conventional MR imaging. Our hypothesis was that classic and atypical meningiomas have different patterns of intratumoral water diffusion that will allow for differentiation between them. MATERIALS AND METHODS:Preoperative diffusion tensor imaging (DTI) was performed in 12 classic and 12 atypical meningiomas. Signal intensity of solid-enhancing tumor regions on diffusion-weighted trace images and apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps was assessed. Regions of interest (ROIs) were placed in solid-enhancing regions, peritumoral edema, and contralateral normal-appearing white matter (NAWM) to measure tensor metrics including major (λ1), intermediate (λ2) and minor eigenvalues (λ3) and FA and ADC values. Distribution of tensor shapes within enhancing tumors was calculated for all tumors. Differences between classic and atypical meningiomas in tumor signal intensity, intratumoral and peritumoral tensor metrics, as well as tensor shapes distribution were statistically analyzed. RESULTS:A significantly greater proportion of atypical meningiomas were isointense and hypointense on ADC maps (P = .007). Classic meningiomas had significantly lower FA (P = .012), higher ADC (P = .011), greater λ2 (P = .020) and λ3 (P = .003). There was significantly more spherical diffusion in classic than in atypical meningiomas (P = .020). All diffusion tensor metrics for peritumoral edema of the 2 tumor groups did not differ. CONCLUSION:DTI showed that intratumoral microscopic water motion is less organized in classic than in atypical meningiomas. This feature may allow for noninvasive differentiation between classic and atypical meningiomas.
Ionización y disociación de H+2 y H2 por pulsos láser ultracortos en la región XUV

En esta tesis se han desarrollado calculos ab initio de la ionizacion multifotonica de moleculas sencillas (H2+ y H2) por pulsos laser en la region XUV y en el dominio de los fs y sub-fs. El principal objetivo de este estudio es demostrar la relevancia de la inclusion del movimiento nuclear para analizar los procesos de ionizacion, tanto disociativos como no disociativos. Particularmente, se analizan las distribuciones de energia cinetica de los nucleos que revelan los efectos resonantes asociados con los estados vibronicos intermedios. Y finalmente, se muestra la clara dependencia de dichas distribuciones energeticas en los procesos de ionizacion con la variacion de la duracion del pulso y/o la intensidad del laser. Los estados ligados y del continuo (tanto electronicos como vibracionales) se obtienen mediante expansiones en funciones de base B-splines. Trabajamos en el marco de la aproximacion dipolar y, para tratar el movimiento de nucleos y electrones, hacemos uso de aproximacion Born-Oppenheimer. Se han llevado a cabo calculos suponiendo un regimen perturbativo, empleando la teoria de perturbaciones independiente del tiempo, y se han comparado con los obtenidos en un regimen no perturbativo resolviendo la ecuacion de Schrodinger dependiente del tiempo. En el caso del ion H2+, se han obtenido las secciones eficaces de ionizacion totales y diferenciales (en la energia de protones y electrones) para diferentes energias de foton, intensidades de laser y duraciones de pulso. Las resonancias apenas se observan en las tasas integradas. A diferencia de los resultados en la aproximacion de nucleos fijos, no aparecen divergencias en el regimen perturbativo a energias resonantes con los estados intermedios cuando el movimiento nuclear de forma apropiada. Como era de esperar, los resultados no perturbativos tienden a los obtenidos en la teoria de perturbaciones cuando la duracion de pulso aumenta y la i
Prevalence of illness, poor mental health and sleep quality and low energy availability prior to the 2016 Summer Olympic Games

Objective Establish the prevalence of illness symptoms, poor sleep quality, poor mental health symptoms, low energy availability and stress-recovery state in an Olympic cohort late in the 3 months prior to the Summer Olympic Games. Methods Olympic athletes (n=317) from 11 sports were invited to complete questionnaires administered 3 months before the Rio 2016 Olympic Games. These questionnaires included the Depression, Anxiety and Stress Questionnaire, Perceived Stress Scale, Dispositional Resilience Scale, Recovery-Stress Questionnaire (REST-Q-52 item), Low Energy Availability in Females Questionnaire (LEAF-Q), Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index and custom-made questionnaires on probiotic usage and travel. Multiple illness (case) definitions were applied. ORs and attributable fractions in the population were used. Factor analyses were used to explore the relationships between variables. Results The response rate was of 42% (male, n=47, age 25.8±4.1 years; female, n=85, age 24.3±3.9 years). Low energy availability was associated with sustaining an illness in the previous month (upper respiratory, OR=3.8, 95% CI 1.2 to 12). The main factor relating to illness pertained to a combination of anxiety and stress-recovery states (as measured by the REST-Q-52 item). All participants reported at least one episode of illness in the last month (100% prevalence). Conclusions All participants reported at least one illness symptom in the previous month. Low energy availability was a leading variable associated with illness in Olympic-class athletes. The estimates duration of symptoms ranged from 2 to 7 days. Factor analyses show the interdependence of various health domains and support multidisciplinary care.
A 0.06 mm2 6 dBm IB1db wideband CMOS class-AB LNTA for SAW-less applications

A wideband low-noise transconductance amplifier (LNTA) with high linearity is proposed. The differential LNTA adopts complementary common-gate, current mirror and common-source (CG-CM-CS) scheme to achieve noise and distortion cancellation and gm-enhancement. The gain expansion of the class-AB CS stage compensates the gain compression of the CG-CM stage, which leads to a high large-signal linearity. A wide input matching bandwidth is achieved by utilizing a pi-type input matching network without the use of on-chip bulky inductors. Designed in a 0.18μm CMOS process, the simulation results show that it provides a minimum NF of 3 dB, and a maximum transconductance of 78.1 mS from 0.1 to 3.6 GHz. An input 1-dB compression/desensitization point and an IIP3 of 8.23/6 dBm and 17.3 dBm, respectively, are obtained. The NF is degraded by 0.3 dB with a 0 dBm blocker. The circuit draws 10.4 mA from a 2.5 V supply and the core area is only 0.5 × 0.12 mm2.
Incidence and Risk Factors for Gadolinium-Based Contrast Agent Immediate Reactions

Abstract Since their clinical introduction in 1988, gadolinium-based contrast agents (GBCAs) have demonstrated an excellent safety profile with a reported acute adverse reaction rate ranging from 0.01% to 2%. By comparison, the acute adverse reaction rate of low osmolar nonionic computed tomography contrast agents (CTCs) ranges from 0.7% to 3.1%. Many of the risk factors associated with CTC reactions (drug allergies, asthma, atopy, prior contrast reaction) also point toward an increased incidence of acute adverse events to GBCAs. With CTCs, an increased adverse event rate was associated with ionic preparations and high osmolality. In response to concerns for nephrogenic systemic fibrosis, GBCAs are now selected for their augmented chemical stability. These agents possess some combination of macrocyclic chelates or ionic preparations. With their improved chemical stability, these agents also possess higher osmolality and the increased potential to elicit an acute adverse reaction. In light of these concerns, researchers are now focusing greater efforts on reexamining acute adverse reactions to GBCAs and whether there is an increased association with certain agents. In addition to hypersensitivity reactions, this article will also discuss contrast extravasations, safety of GBCAs for pregnant and nursing patients, and the potential nephrotoxic effects of GBCAs.
Everolimus in combination with exemestane in the treatment of postmenopausal women with estrogen receptor-positive metastatic breast cancer who are refractory to letrozole or anastrozole: Preliminary results of the BOLERO-2 trial.

e11058 Background: The PI3K/Akt/mTOR pathway, a key regulator of cellular proliferation, cellular metabolism, and angiogenesis, is constitutively activated in aromatase inhibitor-resistant breast cancer. Everolimus (EVE), an inhibitor of the PI3K/Akt/mTOR pathway, has single-agent activity and provides additional efficacy to long-term estrogen deprivation when combined with letrozole in the neoadjuvant setting. Combination of EVE and exemestane may improve outcomes for patients ER+ breast cancer refractory to nonsteroidal aromatase inhibitors (NSAI). METHODS In this multinational, double-blind, placebo-controlled phase III study, postmenopausal women ≥18 years old with ER+ locally advanced or metastatic breast cancer whose disease was refractory to NSAI and documented recurrence or progression were stratified by sensitivity to prior hormonal therapy and the presence of visceral metastasis and then randomized (2:1) to EVE (10 mg daily) or matching placebo orally once daily, with both arms receiving exemestane (25 mg daily). Treatment was continued until disease progression or unacceptable toxicity. The primary outcome was progression-free survival (PFS) assessed by the investigators. Secondary outcomes included overall survival, overall response rate, time to deterioration of ECOG performance status, safety, and change in QoL scores over time. Between June 2009 and January 2011, 723 patients were randomized from 24 countries; 84% had hormone sensitive-disease and 56% had visceral disease. An interim analysis based on safety and efficacy reviewed by the independent data monitoring committee will be performed when 317 PFS events have occurred. The IDMC meeting is planned for May 2011.
A Behavioral Model of the Popularity and Regulation of Demandable Liabilities

Overoptimism regarding one's ability to arrive early in a queue is shown to rationalize deposit contracts in which people can withdraw their funds on demand even if consumption takes place later. Capitalized institutions serving overoptimistic depositors emerge in equilibrium even if depositors and bank owners have identical preferences and investment opportunities. Consistent with the evidence, runs can lead people to move their deposits from one intermediary to another. Regulatory policies, including deposit insurance, minimum capital requirements and restrictions on the assets held by depository institutions can increase the ex ante welfare of depositors. (JEL G21, G28, G32, L51)
The extra L opposed current converter

In existing half/full-bridge high precision amplifiers output distortion is present due to the required switch blanking time. The OCC topology does not require this blanking time but has a much higher total inductor volume compared to the half-bridge. In this paper a patented new topology is introduced that has the advantages of the OCC but with a much lower total inductor volume. The basic operation and properties of the ELOCC topology are explained including optimization of the total inductor volume and an average model for control design. A prototype ELOCC current amplifier has been developed. The behavior of this prototype is in good agreement with the obtained simulation results. Even though the prototype is not fully optimized the harmonic performance is already impressive.
Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals.

Reports on increasing incidences in developmental abnormalities of the human male reproductive tract and the recent identifications of environmental chemicals with antiandrogenic activity necessitate the screening of a larger number of compounds in order to get an overview of potential antiandrogenic chemicals present in our environment. Thus, there is a great need for an effective in vitro screening method for (anti)androgenic chemicals. We have developed a rapid, sensitive, and reproducible reporter gene assay for detection of antiandrogenic chemicals. Chinese Hamster Ovary cells were cotransfected with the human androgen receptor expression vector and the mouse mammary tumour virus (MMTV)2-luciferase vector using the new nonliposomal transfection reagent FuGene. Stimulation of the cells for 24 h with the synthetic androgen receptor agonist, R1881 (10 nM), resulted in a 30- to 60-fold induction of luciferase activity. The classical antiandrogenic compounds hydroxy-flutamide, bicalutamide, spironolactone, and cyproterone acetate together with the pesticide(metabolite)s, vinclozolin, p,p'-DDE, and procymidone all potently inhibited the response to 0.1 nM R1881. Compared to the traditional calcium phosphate transfection method, this method has the advantage of being more feasible, as the assay can be scaled down to the microtiter plate format. Furthermore, the transfection reagent is noncytotoxic, allowing its addition together with the test compounds thereby reducing the hands-on laboratory time. This assay is a powerful tool for the efficient and accurate determination and quantification of the effects of antiandrogens on reporter gene transcription. To extend the application of FuGene, the reagent was shown to be superior compared to Lipofectin for transfecting MCF7 human breast cancer cells with an estrogen response element-luciferase vector. Thus, FuGene may prove to be valuable in diverse reporter gene assays involving transient transfections for screening of potential endocrine disruptors for (anti)androgenic and (anti)estrogenic properties.
Is there a dose-response relation of dietary glycemic load to risk of type 2 diabetes? Meta-analysis of prospective cohort studies.

BACKGROUND Although much is known about the association between dietary glycemic load (GL) and type 2 diabetes (T2D), prospective cohort studies have not consistently shown a positive dose-response relation. OBJECTIVE We performed a comprehensive examination of evidence on the dose response that links GL to T2D and sources of heterogeneity among all prospective cohort studies on healthy adults available in the literature. DESIGN We conducted a systematic review of all prospective cohort studies and meta-analyses to quantify the GL-T2D relation both without and with adjustment for covariates. RESULTS Among 24 prospective cohort studies identified by August 2012, the GL ranged from ∼60 to ∼280 g per daily intake of 2000 kcal (8.4 MJ). In a fully adjusted meta-analysis model, the GL was positively associated with RR of T2D of 1.45 (95% CI: 1.31, 1.61) for a 100-g increment in GL (P < 0.001; n = 24 studies; 7.5 million person-years of follow-up). Sex (P = 0.03), dietary instrument validity (P < 0.001), and ethnicity (European American compared with other; P = 0.04) together explained 97% of the heterogeneity among studies. After adjustment for heterogeneities, we used both funnel and trim-and-fill analyses to identify a negligible publication bias. Multiple influence, cumulative, and forecast analyses indicated that the GL-T2D relation tended to have reached stability and to have been underestimated. The relation was apparent at all doses of GL investigated, although it was statistically significant only at >95 g GL/2000 kcal. CONCLUSION After we accounted for several sources of heterogeneity, findings from prospective cohort studies that related the GL to T2D appear robust and consistently indicate strong and significantly lower T2D risk in persons who consume lower-GL diets. This review was registered at http://www.crd. york.ac. uk/PROSPERO as CRD42011001810.
The yeast SWI-SNF complex facilitates binding of a transcriptional activator to nucleosomal sites in vivo

The Saccharomyces cerevisiae SWI-SNF complex is a 2-MDa protein assembly that is required for the function of many transcriptional activators. Here we describe experiments on the role of the SWI-SNF complex in activation of transcription by the yeast activator GAL4. We find that while SWI-SNF activity is not required for the GAL4 activator to bind to and activate transcription from nucleosome-free binding sites, the complex is required for GAL4 to bind to and function at low-affinity, nucleosomal binding sites in vivo. This SWI-SNF dependence can be overcome by (i) replacing the low-affinity sites with higher-affinity, consensus GAL4 binding sequences or (ii) placing the low-affinity sites into a nucleosome-free region. These results define the criteria for the SWI-SNF dependence of gene expression and provide the first in vivo evidence that the SWI-SNF complex can regulate gene expression by modulating the DNA binding of an upstream activator protein.