Miracle-dz/UniFAR-FTUs huggingface dataset:
People Teach With Rewards and Punishments as Communication, Not Reinforcements

Carrots and sticks motivate behavior, and people can teach new behaviors to other organisms, such as children or nonhuman animals, by tapping into their reward learning mechanisms. But how people teach with reward and punishment depends on their expectations about the learner. We examine how people teach using reward and punishment by contrasting two hypotheses. The first is evaluative feedback as reinforcement, where rewards and punishments are used to shape learner behavior through reinforcement learning mechanisms. The second is evaluative feedback as communication, where rewards and punishments are used to signal target behavior to a learning agent reasoning about a teacher’s pedagogical goals. We present formalizations of learning from these 2 teaching strategies based on computational frameworks for reinforcement learning. Our analysis based on these models motivates a simple interactive teaching paradigm that distinguishes between the two teaching hypotheses. Across 3 sets of experiments, we find that people are strongly biased to use evaluative feedback communicatively rather than as reinforcement.
Sudden Cardiac Death in Hypertensive Patients

In patients with hypertension, but without established cardiovascular disease, predictive factors for sudden cardiac death (SCD) remain undefined. We followed for an average of 10.3 years a cohort of 3242 initially untreated hypertensive patients without evidence of coronary or cerebrovascular heart disease at entry. All patients underwent a complete clinical examination which included ECG and 24-hour ambulatory blood pressure monitoring. At entry, the mean age of patients was 50.0 years, 45% were women, and 6.1% had type 2 diabetes mellitus. Average office blood pressure was 154/96 mm Hg, and average 24-hour ambulatory blood pressure was 136/86 mm Hg. Prevalence of left ventricular hypertrophy at ECG was 13.9%. During follow-up, SCD occurred in 33 patients at a rate of 0.10 per 100 patient-years (95% CI, 0.07–0.14). The rate of SCD was 0.07 and 0.30 per 100 patient-years, respectively, in the cohort of patients without and with ECG left ventricular hypertrophy (P<0.01). In a multivariable Cox model with Firth penalized maximum bias reduction method for rare outcome events, left ventricular hypertrophy almost tripled the risk of SCD (adjusted hazard ratio, 2.99; 95% CI, 1.47–6.09; P=0.002) after adjustment for age (P<0.0001), sex (P=0.019), diabetes mellitus (P<0.0001), and 24-hour ambulatory pulse pressure (P=0.036). For each 10 mm Hg increase in 24-hour ambulatory pulse pressure, the risk of SCD increased by 35%. The time-dependent area under the receiver operating characteristic curve was 0.85 (95% CI, 0.74–0.96). We conclude that in patients with hypertension without established cardiovascular disease, age, diabetes mellitus, ECG left ventricular hypertrophy, and 24-hour ambulatory pulse pressure are independent prognostic markers for SCD in the long-term.
Determination of Picoxystrobin Residues in Watermelon Field Trials by Rapid Resolution Liquid Chromatography Triple Quadrupole Mass Spectrometry: Dissipation Kinetics and Terminal Residues

A simple, rapid and efficient method for the determination of picoxystrobin in watermelon ecosystem was established and validated via QuEChERS (quick, easy cheap, effective, rugged and safe) method using rapid resolution liquid chromatography tandem mass spectrometry (RRLC-MS/MS). The average recoveries (n=5) of picoxystrobin in three matrix at three fortification levels ranged from 89.4% to 102.6%. The limits of detection (LODs) were lower than 1.28×10 _4 mg L 1. The limits of quantification (LOQs) were 0.001 mg kg _1 for watermelon flesh (whole watermelon) and 0.005 mg kg _1 for soil. The half-life of picoxystrobin of whole watermelon (soil) in Shandong and Anhui were 1.43 (4.18) days and 3.71 (17.32) days, respectively. The picoxystrobin terminal residues in watermelon were lower than 0.001 mg kg _1 under the recommended dosages, which were far below the maximum residue limit (MRL) set by China (0.05 mg kg 1). These obtained data not only provide scientific information about safety estimation of picoxystrobin in watermelon and the kinetics of dissipation, but also facilitate trade exportation of watermelon for China.
Incidence of Vibrio parahaemolyticus in and the Microbiological Quality of Seafood in North Carolina 1.

Microbiological analyses of 716 seafood samples over a 3-year period revealed that the microbiological quality of fresh seafood in North Carolina was generally acceptable. The mean aerobic counts (APC) and fecal coliform counts were low as was the occurrence of enteric pathogens, except for Vibrio parahaemolyticus and coagulase-positive staphylococci. Salmonella species were isolated from three samples, but the fecal coliform counts of these samples far exceeded the shellfish standard of the United States Food and Drug Administration. Coagulase-positive staphylococci were isolated in low numbers from nearly all the different types of seafoods; unpasteurized crabmeat and head-peeled shrimp samples showed the highest counts (10% of these samples had numbers which exceeded 100/g). V. parahaemolyticus occurred frequently in fresh seafood (overall 46% of the samples were positive) and its numbers showed a definite seasonal variation. No positive statistical correlation was found between the numbers of V. parahaemolyticus and the bacteriological indices, such as coliforms, fecal coliforms, enterococci and APC. Processing practices were found to influence the occurrence of V. parahaemolvticus in seafood; for example, improperly cleaned flumes were found to be a reservoir for V. parahaemolyticus in mechanical scallop processing plants. Also 'picking' waste 'containers' were found to be sources of V. parahaemolyticus in crab processing plants. Some processing practices such as heat shocking of oysters to facilitate opening were found to reduce the numbers of V. parahaemolyticus . Fifty V. parahaemolyticus isolates from different seafoods were tested for their Kanagawa reaction and all were found to be negative.
Robust and energy-efficient expression recognition based on improved deep ResNets

Abstract To improve the robustness and to reduce the energy consumption of facial expression recognition, this study proposed a facial expression recognition method based on improved deep residual networks (ResNets). Residual learning has solved the degradation problem of deep Convolutional Neural Networks (CNNs); therefore, in theory, a ResNet can consist of infinite number of neural layers. On the one hand, ResNets benefit from better performance on artificial intelligence (AI) tasks, thanks to its deeper network structure; meanwhile, on the other hand, it faces a severe problem of energy consumption, especially on mobile devices. Hence, this study employs a novel activation function, the Noisy Softplus (NSP), to replace rectified linear units (ReLU) to get improved ResNets. NSP is a biologically plausible activation function, which was first proposed in training Spiking Neural Networks (SNNs); thus, NSP-trained models can be directly implemented on ultra-low-power neuromorphic hardware. We built an 18-layered ResNet using NSP to perform facial expression recognition across datasets Cohn-Kanade (CK+), Karolinska Directed Emotional Faces (KDEF) and GENKI-4K. The results achieved better anti-noise ability than ResNet using the activation function ReLU and showed low energy consumption running on neuromorphic hardware. This study not only contributes a solution for robust facial expression recognition, but also consolidates the low energy cost of their implementation on neuromorphic devices, which could pave the way for high-performance, noise-robust and energy-efficient vision applications on mobile hardware.
Introduction: bringing dads back into the family

This Special Issue of Attachment and Human Development provides a family systems perspective on fathers and attachment, and represents a response to a sad fact. Research on mother-child attachment has grown astronomically since the publication of Bowlby’s seminal theory (Bowlby, 1969), Ainsworth’s development of the Strange Situation Procedure (Ainsworth, Blehar, Waters, & Wall, 1978), and Main and her colleagues’ creation of the Adult Attachment interview (Main, Kaplan, & Cassidy, 1985). But over the same period of time, as the authors in this Special Issue all note, attention to the role of fathers in their children’s development has been relatively neglected. Of the small number of researchers who include both parents and their children in their studies, most observe that mothers’ parenting behavior, especially sensitivity, accounts for the child’s security of attachment more strongly than fathers. ’ A vicious cycle has been created in which fathers are seen as absent in the role of primary caretaker of young children, and that cycle has reinforced the culturally stereotypic message that fathers are therefore less important, or even unimportant in children’s development of attachment security. Based on the literature, many conclude that it is not worth the effort that it takes to recruit fathers to participate in new attachment studies. After listening for years to our protests about the persistent mother-centric nature of the field, Howard Steele, Editor of this Attachment and Human Development journal, challenged us to address father absence in the attachment literature by soliciting and editing papers for a Special Issue to highlight studies of fathers, attachment security, and child outcomes. And so, we have joined with 5 other research teams from different parts of the U.S. and Europe to present 6 papers, each of which demonstrates that fathers have an important role to play in the child’s or adolescent’s development of security or insecurity in their relationships with their parents, and in one case (Lux & Walper, 2019, pp. 467–484) with their peers.
Cancer incidence and mortality after heart transplantation – A population-based national cohort study

Abstract Background: Cancer is currently one of the most important factors affecting the long-term health and survival of heart transplant patients. Material and methods: We calculated the standardized incidence ratios (SIR) for different cancer sites and the cancer-specific standardized mortality ratio (SMR) by linking a cohort of 479 adult heart transplant recipients transplanted in 1985–2014 (4491.6 person-years of follow-up) with data from the national Finnish Cancer Registry until the end of 2015, and with the data from the Statistics Finland’s national registry of causes of death. Results: A total of 267 cancers occurred in 143 patients (SIR 6.0; 95% confidence interval (CI) 5.3–6.7). The SIR for overall cancer was considerably higher for men (SIR 6.7; 95% CI 5.9–7.5) than for women (1.4; 95% CI 0.6–2.6). Most frequent cancers were non-melanoma skin cancers (basal cell carcinoma 83 cases, squamous cell skin cancer (SCC) 56 cases), followed by Non-Hodgkin lymphoma (NHL) (36 cases), lung cancer (17), cancer of prostate (16) and cancer of kidney (12). SIRs were highest for SCC (51.9; 95% CI 39.2–67.4), lip cancer (47.4; 95% CI 19.1–97.7), cancer of tongue (26.3; 95% CI 7.2–67.4), and NHL (25.7; 95% CI 18.0–35.6). For most cancers, SIRs increased steadily by time since transplantation. Cancer mortality was three times higher for heart transplant recipients than for the population (SMR 3.1; 95% CI 2.1–4.1). Conclusions: Both cancer incidence and mortality are remarkably increased after heart transplantation, with the relative incidence most elevated for SCC, lip and other oral cancers, and for NHL.
Aperiodic order coming of age: from inorganic materials to dynamic protein superstructures.

University of Nebraska Medical Center, The Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA, Iowa State University, Department of Physics and Astronomy, 12 Physics Hall, Ames, IA 500-1021, USA, and Iowa State University, Department of Chemistry, 1605 Gilman Hall, 2415 Osborn Drive, Ames, IA 50011-1021, USA. *Correspondence e-mail: pthiel@ameslab.gov
The Modern View of B Chromosomes Under the Impact of High Scale Omics Analyses

Supernumerary B chromosomes (Bs) are extra karyotype units in addition to A chromosomes, and are found in some fungi and thousands of animals and plant species. Bs are uniquely characterized due to their non-Mendelian inheritance, and represent one of the best examples of genomic conflict. Over the last decades, their genetic composition, function and evolution have remained an unresolved query, although a few successful attempts have been made to address these phenomena. A classical concept based on cytogenetics and genetics is that Bs are selfish and abundant with DNA repeats and transposons, and in most cases, they do not carry any function. However, recently, the modern quantum development of high scale multi-omics techniques has shifted B research towards a new-born field that we call “B-omics”. We review the recent literature and add novel perspectives to the B research, discussing the role of new technologies to understand the mechanistic perspectives of the molecular evolution and function of Bs. The modern view states that B chromosomes are enriched with genes for many significant biological functions, including but not limited to the interesting set of genes related to cell cycle and chromosome structure. Furthermore, the presence of B chromosomes could favor genomic rearrangements and influence the nuclear environment affecting the function of other chromatin regions. We hypothesize that B chromosomes might play a key function in driving their transmission and maintenance inside the cell, as well as offer an extra genomic compartment for evolution.
Cooking with elaborate recipes can reduce the formation of mutagenic heterocyclic amines and promote co-mutagenic amines

ABSTRACT Heterocyclic amines (HCAs) are foodborne carcinogens for which their formation is highly dependent on cooking conditions. HCAs have been commonly quantified in food items prepared with simple procedures. This approach is suitable for elucidating HCAs’ formation, but it only partially reflects the contamination in consumed food. In the current investigation, the generation of HCAs has been investigated in fried beef items prepared with elaborated cooking recipes, and their occurrence has been compared with control beef fried without the addition of ingredients other than oil. The food recipes that included a variety of food ingredients had lower yields of mutagenic HCAs (≥47% reduction, with individual HCA levels ranging between 0.01 and 2.22 ng/g) with respect to the control beef. In contrast, the co-mutagens norharman and harman were formed generally at greater levels (up to three times the contamination in the control fried beef) in the items prepared including a greater variety of ingredients. Graphical Abstract
Treatment of Patients With Early-Stage Colorectal Cancer: ASCO Resource-Stratified Guideline

PURPOSE To provide resource-stratified, evidence-based recommendations on the treatment and follow-up of patients with early-stage colorectal cancer. METHODS ASCO convened a multidisciplinary, multinational Expert Panel that reviewed existing guidelines and conducted a modified ADAPTE process and a formal consensus process with additional experts for one round of formal ratings. RESULTS Existing sets of guidelines from 12 guideline developers were identified and reviewed; adapted recommendations from six guidelines form the evidence base and provide evidence to inform the formal consensus process, which resulted in agreement of 75% or more on all recommendations. RECOMMENDATIONS For nonmaximal settings, the recommended treatments for colon cancer stages nonobstructing, I-IIA: in basic and limited, open resection; in enhanced, adequately trained surgeons and laparoscopic or minimally invasive surgery, unless contraindicated. Treatments for IIB-IIC: in basic and limited, open en bloc resection following standard oncologic principles, if not possible, transfer to higher-level facility; in emergency, limit to life-saving procedures; in enhanced, laparoscopic en bloc resection, if not possible, then open. Treatments for obstructing, IIB-IIC: in basic, resection and/or diversion; in limited or enhanced, emergency surgical resection. Treatment for IIB-IIC with left-sided: in enhanced, may place colonic stent. Treatment for T4N0/T3N0 high-risk features or stage II high-risk obstructing: in enhanced, may offer adjuvant chemotherapy. Treatment for rectal cancer cT1N0 and cT2n0: in basic, limited, or enhanced, total mesorectal excision principles. Treatment for cT3n0: in basic and limited, total mesorectal excision, if not, diversion. Treatment for high-risk patients who did not receive neoadjuvant chemotherapy: in basic, limited, or enhanced, may offer adjuvant therapy. Treatment for resectable cT3N0 rectal cancer: in enhanced, base neoadjuvant chemotherapy on preoperative factors. For post-treatment surveillance, a combination of medical history, physical examination, carcinoembryonic antigen testing, imaging, and endoscopy is performed. Frequency depends on setting. Maximal setting recommendations are in the guideline. Additional information can be found at www.asco. org/resource-stratified-guidelines. NOTICE It is the view of the American Society of Clinical Oncology that health care providers and health care system decision makers should be guided by the recommendations for the highest stratum of resources available. The guidelines are intended to complement but not replace local guidelines.
Assessing the impact of climate change on the worldwide distribution of Dalbulus maidis (DeLong) using MaxEnt.

BACKGROUND For the first time, a model was applied at the global scale to investigate the effects of climate change on Dalbulus maidis. D. maidis is the main vector of three plant pathogens of maize crops and has been reported as one of the most important maize pests in Latin America. We modelled the effects of climate change on this pest using three Global Climate Models under two Representative Concentration Pathways (RCPs) using MaxEnt software. RESULTS Overall, climate change will lead to a decrease in suitable areas for D. maidis. In South America, climate change will decrease the areas suitable for the pest, especially in Brazil. However, Argentina, Chile, Colombia, Ecuador, Peru and Venezuela will have small areas that are highly suitable for the corn leafhopper. Outside the pest's range, Ethiopia, Kenya, Rwanda, Burundi and South Africa also should be concerned about the risk of corn leafhopper invasions in the future because they are projected to have conditions that are highly suitable for this insect in some areas. CONCLUSION This study allows the relevant countries to increase their quarantine measures and guide researchers to develop new Zea mays varieties that are resistant or tolerant to D. maidis. In addition, the maize-stunting pathogens for the areas are highlighted in this modelling. © 2019 Society of Chemical Industry.
Catastrophic Mortality, Allee Effects, and Marine Protected Areas

For many species, reproductive failure may occur if abundance drops below critical Allee thresholds for successful breeding, in some cases impeding recovery. At the same time, extreme environmental events can cause catastrophic collapse in otherwise healthy populations. Understanding what natural processes and management strategies may allow for persistence and recovery of natural populations is critical in the face of expected climate change scenarios of increased environmental variability. Using a spatially explicit continuous-size fishery model with stochastic dispersal parameterized for abalone—a harvested species with sedentary adults and a dispersing larval phase—we investigated whether the establishment of a system of marine protected areas (MPAs) can prevent population collapse, compared with nonspatial management when populations are affected by mass mortality from environmental shocks and subject to Allee effects. We found that MPA networks dramatically reduced the risk of collapse following catastrophic events (75%–90% mortality), while populations often continued to decline in the absence of spatial protection. Similar resilience could be achieved by closing the fishery immediately following mass mortalities but would necessitate long periods without catch and therefore economic income. For species with Allee effects, the use of protected areas can ensure persistence following mass mortality events while maintaining ecosystem services during the recovery period.
Prior Knowledge of the Mediterranean Diet Is Associated With Dietary Adherence in Cardiac Patients

Abstract Context Cardiovascular disease (CVD) is the leading cause of death in the United States, and cardiovascular events have been shown to be reduced and prevented when patients follow the Mediterranean diet. Objective To understand how familiarity with the Mediterranean diet affects dietary habits in cardiology patients by using social cognitive theory. Method This cross-sectional study included patients at a metropolitan outpatient cardiology clinic in Oklahoma. A survey was used to analyze patient knowledge of the Mediterranean diet. Patients were separated into low–, medium–, and high–diet adherence groups based on their daily consumption of fruits, vegetables, fish, whole grains, and nuts. Multinomial logistic regression was used to analyze patients’ knowledge of Mediterranean diet principles with dietary adherence. Results A total of 337 patients were included in the study. Patients with a college education, patients reporting familiarity with the diet, and women were 6.7, 4.0, and 3.2 times as likely, respectively, to have strong adherence to the Mediterranean diet. Conclusion The finding that familiarity with the Mediterranean diet was closely associated with adherence to its principles indicates that patient education on heart-healthy diets may improve the eating habits of patients, especially patients at risk for cardiac events.
Short-Term Outcomes of Percutaneous Trephination with a Platelet Rich Plasma Intrameniscal Injection for the Repair of Degenerative Meniscal Lesions. A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study

Meniscal tears are the most common orthopaedic injuries, with chronic lesions comprising up to 56% of cases. In these situations, no benefit with surgical treatment is observed. Thus, the purpose of this study was to investigate the effectiveness and safety of percutaneous intrameniscal platelet rich plasma (PRP) application to complement repair of a chronic meniscal lesion. This single centre, prospective, randomized, double-blind, placebo-controlled study included 72 patients. All subjects underwent meniscal trephination with or without concomitant PRP injection. Meniscal non-union observed in magnetic resonance arthrography or arthroscopy were considered as failures. Patient related outcome measures (PROMs) were assessed. The failure rate was significantly higher in the control group than in the PRP augmented group (70% vs. 48%, P = 0.04). Kaplan-Meyer analysis for arthroscopy-free survival showed significant reduction in the number of performed arthroscopies in the PRP augmented group. A notably higher percentage of patients treated with PRP achieved minimal clinically significant difference in visual analogue scale (VAS) and Knee injury and Osteoarthritis Outcome Score (KOOS) symptom scores. Our trial indicates that percutaneous meniscal trephination augmented with PRP results in a significant improvement in the rate of chronic meniscal tear healing and this procedure decreases the necessity for arthroscopy in the future (8% vs. 28%, P = 0.032).