Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Shift Work on the Level of Self-Rated Health.

Objectives: The present study was designed to determine the characteristics of shift work and the relationship between shift work and the level of self-rated health using the Korean Labor and Income Panel Study (KLIPS) data, which represents urban households in Korea. Methods: Using the 9th wave of KLIPS, this study analyzed 2,087 male workers aged 25 to 64 years; participants missing data were excluded from analysis. To determine the impact of shift work on the level of self-rated health, logistic regression analysis was applied that controlled for socio-demographic characteristics, labor environment, and health-related behaviors. Results: Shift workers comprised 13.4% of study subjects overall. The majority(69.2%) of participants were in 2-teams and in 2-shifts. Week 1 shift cycle changes were the highest, 56.3%. The risk of poor self-rated health was not significantly higher among shift workers compared to non-shift workers (OR=1.08, 95% CI=0.79~1.48). When divided by tenure, shift workers with more than 10-years experience (OR=1.79, 95% CI=0.91~3.50) tended to show greater risk than non-shift workers at marginal sig-nificance. Conclusions: In the present study, a significantly higher risk of self-rated poor health among shift workers was not observed. However, shift workers with more than 10-years experience tended to show increased health risk compared to non-shift workers. Further studies are required to determine time-series data and to consider both healthy worker effect and information bias.
Unanticipated Difficult Nasal Intubation Due to a Prominent Anterior Tubercle of the First Cervical Spine

Nasal intubation is frequently used for airway management in patients undergoing many surgical procedures. This is a case report of an unanticipated difficult nasal intubation due to a prominent anterior tubercle of the first cervical spine vertebra (C1) resulting in aspiration of blood and hypoxemia following intubation. The subsequent airway management of the rescheduled elective case is also described. The specific difficulties in securing the airway for nasal intubation are described as well as the management strategies to circumvent this anatomical variant. This case report will be of interest to health care practitioners providing airway management via the nasal route for different populations. Citation: David Watton, Orlando R. Hung. Unanticipated difficult nasal intubation due to a prominent anterior tubercle of the first cervical spine. J Anesth Perioper Med 2016; 3: 276-9. doi: 10.24015/JAPM.2016. 0037This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Plasma renalase as a biomarker of acute kidney injury after cardiac surgery

Background Renal ischemia/reperfusion injury is a major cause of acute renal failure. The lack of validated early biomarkers for predicting acute kidney injury (AKI) has hampered our ability to initiate potentially preventive and therapeutic measures in an opportune way. We tested the hypothesis that plasma renalase is an early biomarker for ischemic renal injury after cardiac surgery. Patients and methods We prospectively evaluated 40 adult patients who underwent cardiac surgery. Patients were divided into the AKI group and the non-AKI group on the basis of whether they developed postoperative AKI within 48 h after surgery. Plasma renalase levels were measured before surgery and 24 h after surgery. The primary outcome was AKI diagnosed using the Acute Kidney Injury Network criteria. Results Twenty-five (62.5%) patients developed AKI after surgery. Plasma renalase decreased significantly from a mean of 1.2±0.46 ng/ml at baseline to 0.9±0.42 ng/ml 24 h after cardiopulmonary bypass, with a mean %change of 27±14.8 in the AKI group. Univariate analysis showed a significant correlation between AKI and the following: %change in plasma renalase, cardiopulmonary bypass time, and aortic cross-clamp time. Receiver operating characteristic curve analysis revealed that for %change in plasma renalase concentrations at 24 h, the area under the curve was 0 · 9, sensitivity was 0.92, specificity was 0 · 87, and likelihood ratio was 7.07 for a cutoff value of 9% change. Conclusion Plasma renalase %change is more valid compared with renalase before or after procedure and neutrophil gelatinase-associated lipocalin in the prediction of AKI and represents a novel and highly predictive early biomarker for AKI after cardiac surgery.
Granular cell tumour of the skin (Abrikossoff’s tumour) – case report and review of the literature

Granular cell tumour, also known as Abrikossoff’s tumour, is an uncommon tumour of nerve sheath origin. The average age of presentation is the fourth or fifth decade of life. The most common locations include soft tissues, skin and mucosa of the upper respiratory and digestive tract. Tumours are usually solitary. Multiple foci were observed in about 10-25% of cases and malignant course in about 3-7%. The treatment of choice is radical resection with clear surgical margin. The authors present a case of a 15-year-old boy with granular cell tumour of the skin of the arm.
PREVALENCE AND FACTORS ASSOCIATED WITH OBESITY AMONG ADULT AT THE KAMPUNG KOLAM, EAST COAST MALAYSIAN PENINSULA-A CROSS SECTIONAL STUDY

Objective: This study assesses the prevalence of obesity and its associated factors among adults aged 18 y and above at the Kampaung kolam, Kuala Terengganu, Malaysia. Methods: This cross-sectional survey comprised of a semi-structured face to face interview questionnaire and collected anthropometric measurements and sex specific waist circumference in cm. The study population was 70 in total with 21 (30%) males and 49 (70%) females aged 18 y and above were selected by universal sampling. Body mass index (BMI) was used for weight status and sex specific waist circumference (WC) in cm was used for assessment of abdominal or central obesity at risk of metabolic complications associated with obesity. Results: Among men, the prevalence of underweight was 9.5%, normal weight 57.1%, overweight 14.3% and obesity 19.1%, while among women, the prevalence of underweight was 12.2%, normal weight 53.1%, overweight 14.3% and obesity 20.4%. Overall, 18 (25.7%) was obese and 52 (74.3%) was non-obese while sex specific WC in cm 19 (27.1%) was abdominal obese who were at risk of metabolic complication associated with obesity and 51 (72.9%) was not at risk. In chi-square association tests revealed that among respondents, currently married, unemployed and having family history with obesity were associated with generalized obesity while respondents who were currently married and having fast food frequently were associated with abdominal obesity and respondents who being currently married, unemployed and having fast food frequently were more likely to obese in generalized as well as abdominally. Conclusion: There was no association between generalized, abdominal and generalized and abdominal obesity with age, gender, education, flat floor structure, dietary patterns and habits, physical activities, sleep pattern and knowledge and attitude level towards obesity but those factors can be utilized in effective health promotion programmers of weight management strategies by targeting those factors in design for prevention of hypertension, diabetes and related cardio vascular diseases CVD.
SUSCEPTIBILITY PATTERN OF CARBAPENEM-RESISTANT CLINICAL ISOLATES OF ACINETOBACTER SPP.

Acinetobacter spp. is an opportunistic Gram-negative organism which causes infections in seriously ill, hospitalized individuals, mostly surgical patients, those on artificial ventilation, as well as those on long-term antibiotic treatments. The characteristic of clinical isolates of Acinetobacter spp. is resistance to a large number of antibiotics. Carbapenems are the approach of choice in the treatment of severe infections, although resistance to these has also been reported in the literature. Our study aims to establish the proportion of carbapenem-resistant clinical isolates of Acinetobacter spp. and to examine their susceptibility to other classes of antibiotics. The study involved 175 isolates of Acinetobacter spp. from the material of patients hospitalized at the Clinical Centre Niš in the period from January to September 2016. Patient material consisted of endotracheal aspirates and samples from the patients with soft tissue infections. Testing of susceptibility to antimicrobial drugs was done using disk diffusion methodology on Mueller Hinton agar with gentamicin, amikacin, tobramycin, ciprofloxacin, levofloxacin, cotrimoxazole, imipenem, and meropenem disks (Bio-Rad, France). Susceptibility testing and interpretation of inhibition zones was done abiding by the EUCAST standard guidelines. Isolates resistant to imipenem and meropenem were tested for susceptibility to colistin and tigecycline, establishing with the Etest assay (Liofilchem, Italy) their minimum inhibitory concentrations (MICs). The MIC values for colistin were interpreted based on the EUCAST recommendations, while the MIC values for tigecycline were interpreted according to the recommendations by the Food and Drug Administration (FDA). The isolates resistant to at least three classes of antibiotics were considered multiresistant (MDR). Of 175 examined clinical isolates of Acinetobacter spp. , 50 (28.57%) isolates were obtained from endotracheal aspirates, and 125 from the patients with soft tissue infections. Twenty-nine (16.57%) isolates were susceptible to the tested carbapenems. Carbapenem-resistant isolates were mostly susceptible to tobramycin (26.76%), while only 8.9% were susceptible to cotrimoxazole, 1.37% to ciprofoxacin, and 0.69% (1 isolate) to levofloxacin. All tested isolates (137) were sensitive to colistin (MIC ranging from 0.5 μg/ml to 2.0 μg/ml). Of 106 isolates tested to tigecycline, 83 (78.30%) were susceptible (MIC≤2 μg/ml), while 23 isolates showed reduced susceptibility (MIC ranging from 3.0 μg/ml to 6.0 μg/ml). For colistin, MIC50 and MIC90 were 1.0 μg/ml and 1.5 μg/ml, respectively, and for tigecycline 1.5 μg/ml and 3.0 μg/ml, respectively. All carbapenemresistant Acinetobacter spp. isolates were mutiresistant. In our study, there were no isolates resistant to colistin, the last-resort antibiotic. It is required only for infections caused by MDR isolates, with continuous susceptibility surveillance. Acta Medica Medianae 2016;55(4):86-91.
The effectiveness of long-pulse 1064 nm neoymium-doped yttrium aluminum garnet laser for recalcitrant palmoplantar and ungual warts

www.turkderm. org.tr Yazışma Adresi/Address for Correspondence: Dr. Ali Balevi, Medipol Üniversitesi Tıp Fakültesi, Dermatoloji Anabilim Dalı, İstanbul, Türkiye Tel. : +90 212 460 71 96 E-posta: ali.balevi@gmail.com Geliş Tarihi/Received: 15.07. 2014 Kabul Tarihi/Accepted: 29.12. 2014 'Bu çalışma, 21-25 Ekim 2014 tarihleri arasında Antalya'da düzenlenen ''25. Ulusal Dermatoloji Kongresi''nde en iyi araştırma poster ödülüne layık görülmüştür.
Investigating neurobiological mechanisms underlying comorbid cognitive symptoms in psychosis and substance use

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Urinary and fecal incontinence, pelvic floor disorders, sexual dysfunction and overweight, obesity and metabolic syndrome

Nietrzymanie moczu, nietrzymanie stolca, zaburzenia seksualne u kobiet i zaburzenia erekcji występują znamiennie częściej u osób z nadwagą i otyłością. Nietrzymanie moczu częściej stwierdza się u kobiet z otyłością brzuszną (wisceralną) i wiąże się ze zwiększonym ciśnieniem w jamie brzusznej zwiększającym wtórnie ciśnienie w pęcherzu. Zaburzenia życia seksualnego są szczególnie częste u kobiet z towarzyszącym otyłości nietrzymaniem moczu, stolca, upośledzeniem czynności zwieraczy i wypadaniem narządów miednicy mniejszej. Nietrzymanie moczu u kobiet i zaburzenia erekcji u mężczyzn są wprost proporcjonalne do obecności poszczególnych składowych zespołu metabolicznego: hiperlipemii, hiperglikemii, zwiększonego stężenia CRP (C-reactive protein), czynnika martwicy nowotworów α (tumor necrosis factor α – TNF-α), interleukiny 6 (IL-6), IL-8, IL-18, nadciśnienia, zmian miażdżycowych w naczyniach i stłuszczenia wątroby. W patologii zaburzeń erekcji ważne jest typowe dla zespołu metabolicznego upośledzenie syntezy tlenku azotu odpowiedzialnego za rozszerzenie naczyń. Leczenie dietetyczne, zwiększenie wysiłku fizycznego, a u osób z otyłością powyżej 30. roku życia leczenie chirurgiczne znacząco ograniczają wyżej wymienione objawy. Słowa kluczowe: nietrzymanie moczu, nietrzymanie stolca, życie seksualne, otyłość, zespół metaboliczny.
Relationship between Intra Ocular Pressure and Some Risk Factors, In Northern Iran

High intra ocular pressure (IOP) often is related with open angle glaucoma. Although patients with high IOP are disposable to risk of open angle glaucoma, most of them never given it. In this study we evaluated association of hypertension and some other underlying causes with high IOP in population of patients referred to Amiralmomenin hospital during 2011-2012. This was a descriptive prospective study. Population was included patients with high IOP referred during 2012 to Amiralmomenin Hospital in Rasht. 180 patients with high IOP entered in the study. IOP of both eyes, systolic and diastolic blood pressure in admission were measured by expert assistant of ophthalmology and recorded. 55% of our patients were women. The mean age of them was 67.64±11.88 years. The mean systolic and diastolic blood pressure were respectively 128.66 ± 16.71 and 77.00 ± 9.02 mmHg. There was a significant relation between gender, history of hypertension, alcohol abuse, hyperlipidemia and cardiac disease with high IOP in right eye (p 0.05). Our study showed that systolic blood pressure can predict the high IOP. The results indicate a high impact of intraocular pressure on measures of blood pressure in an Iranian sample population.
AUTOLYTIC AND PROTEOLYTIC PROCESSES OF CALCIUM-ACTIVATED NEUTRAL PROTEASE ARE INDEPENDENT FROM EACH OTHER

To confirm the existence of an autolytic process, independent of the protease activity towards substrate, in the activation of calcium-activated neutral protease (CANP), differences in the mode of autolysis and proteolysis were examined. While the optimal pH for proteolysis by autodigested ,uCANP is 7.2, the pH optimum for the autolysis by native ,uCANP is higher than pH 8. The calcium ion-requirements for the two reactions are different, and the rate of autolysis increases rather than decreases in the presence of substrate.
The influence of race on SLP utilisation and costs among persons with aphasia

ABSTRACT Background: Recent evidence suggests racial disparities exist in post-stroke conditions such as aphasia, yet the underlying cause of such disparities is unclear. Disparities in rehabilitation service utilisation have been previously proposed as a contributor to racial disparities in post-stroke outcomes. Aim: To examine racial differences in speech–language pathology (SLP) service utilisation and costs among persons with aphasia being treated in acute care hospitals in North Carolina. Methods & Procedures: The North Carolina Healthcare Cost and Utilization Project data from 2011 to 2012 were analysed to examine SLP service utilisation and costs for stroke patients with aphasia. Analyses included length of stay (LOS) and charges/costs of SLP services. Generalised linear models were constructed to determine the impact of demographic characteristics, stroke severity, residence, and hospital fixed effects (variability of hospital management practices) on SLP utilisation and costs. Outcomes & Results: Approximately 5% more Blacks with aphasia were seen for SLP services than Whites with aphasia. LOSs were 2.1 days longer in acute care at 17% greater cost. Generalised linear models showed that Blacks with aphasia were seen for approximately 0.416 more visits than Whites after controlling for demographic characteristics, stroke/illness severity and residence and 0.25 more visits after controlling for hospital fixed effects. The slight increase in visits occurred at a cost of $57 when controlling for demographic characteristics, $63 when controlling for stroke/illness severity, $50 when controlling for residence, and $23 when controlling for hospital fixed effects. Conclusions: Blacks with aphasia utilise more SLP services during longer LOSs and with greater costs when compared to Whites with aphasia.
Clinical Trial Performance in Metastatic Colorectal Cancer: An Evaluation of Participating Centers in the CAIRO Studies of the Dutch Colorectal Cancer Group

Objective: High quality clinical trials are essential for further improvement of treatment strategies for prolonged survival and reliable evidence-based outcomes. However, there are no defined standards for the quality of clinical trial performance. The aim of this study is to examine and compare clinical trial performance with a composite score between (different types of) hospitals, to identify potentially predicting factors for a high trial performance and examine a learning curve in composite performance scores between early compared to subsequent included patients. Methods: We evaluated trial performance in three large phase 3 randomized clinical trials in metastatic colorectal cancer (CAIRO studies of the Dutch Colorectal Cancer Group, total n=2131) with a newly introduced composite score, consisting of stratification errors, major protocol violations, number of included ineligible patients, and reporting of serious adverse events (SAE) on hospital and patient level. These data were supplemented with a hospital survey containing questions about number of beds, oncologists and research nurses. A logistic regression was performed to identify factors associated with better trial performance (3-4 points). Results: We observed variation in trial performance between 84 participating hospitals. However, no differences in performance between hospital categories (university, teaching and regional hospitals) were identified and none of the examined variables could be linked to a high composite performance score. In top 10 ranking hospitals with highest inclusion rates, trial performance on patient level was significantly lower in the first three inclusions compared to subsequent patients. Conclusions: Trial performance was comparable between different types of hospitals and no factors were able to predict a high composite trial performance score. In the highest including hospitals we identified a learning curve for trial performance. We therefore recommend increased support during the first patient inclusions in participating centres in order to improve trial performance. Our composite score could be used as a quality metric for trial performance for individually based hospital evaluation.
Alberta stroke program early CT score : ASPECTS

Le rt-PA administré par voie intraveineuse dans les 3 heures après le début des symptômes est le seul traitement approuvé pour les infarctus ischémiques cérébraux (AIC). Bien qu’il entraîne un risque d’hémorragie cérébrale grave, éventuellement mortelle, le rapport risque/bénéfice est en sa faveur, sous réserve que les conditions de prescription, d’administration et de sélection de patients définies par les études prospectives soient respectées. Des anomalies précoces d’ischémie identifiées pendant les premières heures de l’AIC sur le scanner cérébral étaient fréquemment associées à un pronostic défavorable et à un taux augmenté de saignement secondaire après traitement par rt-PA (1). Dans l’étude NINDS, la présence au scanner de signes précoces d’ischémie cérébrale à plus d’un tiers du territoire de l’artère cérébrale moyenne (ACM) constituait un facteur d’exclusion. Cependant, l’analyse rétrospective de cette étude a montré une divergence interobservateur pour déterminer les signes précoces de l’ischémie (une souffrance supérieure à un tiers du territoire de l’ACM) entre les neuroradiologues (taux de divergence ± 23 %), les médecins urgentistes, les neurologues et les radiologues généraux (2).
Effect Of Pre-Emptive Bupivacaine Infiltration On Post Thyroidectomy Pain

45 patients undergoing thyroidectomy were randomly divided into three groups; A, B and C. The protocol for induction and maintenance of general anaesthesia was similar for all three groups. Group A patients received 10 ml of 0.5% bupivacaine infiltration five minutes before skin incision, and 10 ml of 0.9% saline infiltration at the end of surgery. In group B saline infiltration was done before surgical incision, and 10 ml of 0.9% bupivacaine was infiltrated at the end of surgery. In group C (control group) 10 ml of 0.9% saline was infiltrated both before and end of the surgery. Post-operative pain was evaluated at 30 min, 2, 4 and 24 hr after surgery by 10 mm visual analogue score (VAS). Time for first analgesic request and total amount of pethidine consumed in 24 hr were recorded. Group A patients made first analgesic request after 125.3±42.5 min, in group B was 207.0 ± 8.36 minutes and in group C was 34.5 ± 26.6 min. The difference between these groups was statistically significant P value < 0.05. By the end of 24 hr, total consumption of pethidine in group A was 125.3 ± 42.5 mg, in group B was 143.3 44.2 mg and in group C was 191.6 ± 54.6 mg. There was no statistically significant difference in total consumption of pethidine between group A and B. But the difference between C and two groups A and B was significant. Group C patients showed higher pain intensity on VAS both clinically and statistically. We conclude that preemptive 0.5% bupivacaine infiltration improved the quality of post operative analgesia, but larger sample size study is required to prove statistical significance.
The effect of applying a head-weight device on cervical angle and pain of neck muscles

Objective: The purpose of this study was to measure the change in pain threshold of levator scapular muscle, carniovertebral angle, and head position angle when applying a head-weight device on healthy adult. Design: Cross-sectional study. Methods: This study was conducted with 21 healthy adult male and female who voluntarily agreed to participate in this study after being informed of the purpose and method of this study. After measuring the cervical angle and pain threshold of levator scapular muscle, subject was instructed to walk for 5 minutes on a treadmill at a speed of less than 5 km/h while wearing after wearing head-weight device of 0.5 kg. Then, cervical spine angle and pain threshold of levator scapula muscle were re-measured. Measurement of cervical spine angle was conducted with photo by using the Bluebeam Revu software and the pain pressure thresholds (PPTs) were measured using an electronic algometer over potential trigger points on the body. Results: The results cervical angle showed a significant change, from to (p