Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimal loading for peak power output during the hang power clean in professional rugby players.

PURPOSE The ability to develop high levels of muscle power is considered an essential component of success in many sporting activities; however, the optimal load for the development of peak power during training remains controversial. The aim of the present study was to determine the optimal load required to observe peak power output (PPO) during the hang power clean in professional rugby players. METHODS Twelve professional rugby players performed hang power cleans on a portable force platform at loads of 30%, 40%, 50%, 60%, 70%, 80%, and 90% of their predetermined 1-repetition maximum (1-RM) in a randomized and balanced order. RESULTS Relative load had a significant effect on power output, with peak values being obtained at 80% of the subjects' 1-RM (4466 +/- 477 W; P < .001). There was no significant difference, however, between the power outputs at 50%, 60%, 70%, or 90% 1-RM compared with 80% 1-RM. Peak force was produced at 90% 1-RM with relative load having a significant effect on this variable; however, relative load had no effect on peak rate of force development or velocity during the hang power clean. CONCLUSIONS The authors conclude that relative load has a significant effect on PPO during the hang power clean: Although PPO was obtained at 80% 1-RM, there was no significant difference between the loads ranging from 40% to 90% 1-RM. Individual determination of the optimal load for PPO is necessary in order to enhance individual training effects.
HUMAN RESOURCES MOBILIZATION; AN IMPORTANT FACTOR FOR EDUCATIONAL MANAGEMENT AND DEVELOPMENT

Personnel in educational institution are a strong resource for its development and valuable in the accomplishment of the organizational objectives. The productivity of an educational institution is strongly related to its people and strategies. Some of them identify with the school and are motivated in helping to reach goals, while others see the school as a vehicle meant to satisfy their own targets. The personnel of a school brings along a wide range of qualifications, abilities, and knowledge, which might not necessarily be beneficial to the school. This paper examines the value of motivation regarding the productivity of staff members
Injection laryngoplasty for management of unilateral vocal fold paralysis

Purpose of reviewThe purpose of this review is to provide an up-to-date review of injection laryngoplasty technique and currently available injectable materials in the management of unilateral vocal fold paralysis (UVP). Recent findingsMany new materials are currently available as substances for injection laryngoplasty. These materials have been developed along distinct of lines reasoning that address the inherent shortcomings of the previously available injectable substances, namely, poor tissue biocompatibility and poor persistence within the larynx. Accordingly, the past decade has seen heightened efforts toward developing implants with improved biocompatibility and longevity. The past year has witnessed publications reporting animal studies and, on occasion, human clinical trials involving the intralaryngeal injection of calcium hydroxyl-appetite, autologous fascia, particulate silicone and hyaluronic acid derivatives, and others, for managing glottic insufficiency. SummaryIn recent years, the application of injection laryngoplasty to unilateral vocal fold paralysis (UVP) has regained popularity. The technique of injection laryngoplasty has several appealing qualities including relative technical ease, low cost, and wide availability in many clinical settings. A growing number of injectable substances have been developed and tested in the clinical setting of glottic insufficiency. When used to manage unilateral vocal fold paralysis, however, injection laryngoplasty has one irrefutable shortcoming: an inability to address posterior glottic insufficiency. Therefore, while injection laryngoplasty technique becomes increasingly popular for vocal fold augmentation in cases vocal fold paresis, atrophy, and scarring, its role in the treatment of UVP should be limited to cases with an appropriate glottal defect. These techniques should be considered as part of a complimentary armamentarium with framework surgery.
Seizures associated with ertapenem use in patients with CNS disorders and renal insufficiency

Three patients presented seizures during ertapenem therapy. They were classified as probably-related in 1 case and as possible-related in the others. Convulsions appeared after 1 week of therapy at usual doses with 1 or 2 events, and were observed only among patients with CNS disorders and renal insufficiency.
Enzymes of the beta-ketoadipate pathway in Pseudomonas putida: kinetic and magnetic resonance studies of the cis,cis-muconate cycloisomerase catalyzed reaction.

Steady-state kinetic analysis of the divalent metal ion requiring cis,cis-muconate cycloisomerase catalyzed interconversion of cis,cis-muconate and (+)-muconolactone obeys Michaelis-Menten kinetics and the Haldane relationship from pH 6.2 to 8.3. The pH vs. kcat/Km profiles suggest free-enzyme apparent pKa values of 6.2 and 7.4: the reciprocal behavior of the data with respect to the latter pKa value is consistent with base-acid catalysis by the enzyme involving proton removal from the lactone and protonation of cis,cis-muconate, respectively. This catalysis by the enzyme of proton transfer is consistent with the stereospecific incorporation of solvent deuterium into the pro-5R position of (+)-muconolactone in the enzyme-catalyzed reaction: in reverse, the departure of the carboxylic oxygen atom and proton from the C(4) and C(5) carbon atoms follows a syn (cis) route [Avigad, G. , & Englard, S. (1969) Fed. Proc., Fed. Am. Soc. Exp. Biol. 28, 345, Abstr. 486]. The titration of enzyme freed of divalent metal ion with manganous ion, monitored by electron paramagnetic resonance spectroscopy and steady-state kinetic measurements, indicates a single binding site per subunit characterized by KdissE X Mn = [E] [Mn2+]/[E X Mn2+] = 4.5 and 3.0 microM, respectively, the latter value analyzed via a rapid equilibrium mechanism. The paramagnetic effects of Mn2+ on the 1/T1 and 1/T2 values for the H-5S proton of (+)-muconolactone in the E X ML X Mn ternary complex provide an estimate of the correlation time, tau c, at 5 X 10(-9) s from the T1/T2 ratio, indicating that the condition of rapid exchange of (+)-muconolactone in solution with the ternary complex obtains. (ABSTRACT TRUNCATED AT 250 WORDS)
Reward Selectively Modulates the Lingering Neural Representation of Recently Attended Objects in Natural Scenes

Theories of reinforcement learning and approach behavior suggest that reward can increase the perceptual salience of environmental stimuli, ensuring that potential predictors of outcome are noticed in the future. However, outcome commonly follows visual processing of the environment, occurring even when potential reward cues have long disappeared. How can reward feedback retroactively cause now-absent stimuli to become attention-drawing in the future? One possibility is that reward and attention interact to prime lingering visual representations of attended stimuli that sustain through the interval separating stimulus and outcome. Here, we test this idea using multivariate pattern analysis of fMRI data collected from male and female humans. While in the scanner, participants searched for examples of target categories in briefly presented pictures of cityscapes and landscapes. Correct task performance was followed by reward feedback that could randomly have either high or low magnitude. Analysis showed that high-magnitude reward feedback boosted the lingering representation of target categories while reducing the representation of nontarget categories. The magnitude of this effect in each participant predicted the behavioral impact of reward on search performance in subsequent trials. Other analyses show that sensitivity to reward—as expressed in a personality questionnaire and in reactivity to reward feedback in the dopaminergic midbrain—predicted reward-elicited variance in lingering target and nontarget representations. Credit for rewarding outcome thus appears to be assigned to the target representation, causing the visual system to become sensitized for similar objects in the future. SIGNIFICANCE STATEMENT How do reward-predictive visual stimuli become salient and attention-drawing? In the real world, reward cues precede outcome and reward is commonly received long after potential predictors have disappeared. How can the representation of environmental stimuli be affected by outcome that occurs later in time? Here, we show that reward acts on lingering representations of environmental stimuli that sustain through the interval between stimulus and outcome. Using naturalistic scene stimuli and multivariate pattern analysis of fMRI data, we show that reward boosts the representation of attended objects and reduces the representation of unattended objects. This interaction of attention and reward processing acts to prime vision for stimuli that may serve to predict outcome.
Effect of protein binding in serum on therapeutic efficacy of cephem antibiotics

The effect of protein binding in serum of eight cephem antibiotics (ceftazidime, ceftizoxime, cefotiam, cefmetazole, cefpiramide, cefazolin, cefuzonam, ceftriaxone) on their therapeutic efficacies was examined in mice with experimentally induced intraperitoneal infections or pneumonia. The relationship among therapeutic activity, in vitro antibacterial activity, total or free (unbound) levels in serum, and homogenized whole lung levels was investigated. In the intraperitoneal infection caused by Staphylococcus aureus or Klebsiella pneumoniae, the 50% effective doses (ED50s) of the cephem antibiotics correlated with the area under the concentration-time curve (AUC) values of free levels in serum and the MICs but not with those of total levels in serum. A linear relationship was seen between 1/ED50 values and AUC of free levels in serum/MIC values. On the other hand, in mice with pneumonia caused by K. pneumoniae, the number of bacteria in the lung closely correlated with the AUC of the antibiotic concentration in lung tissue. There was a direct correlation between the levels in lung tissue and total levels in serum but not free levels in serum. The cephem antibiotics tested in this study were bound only slightly to homogenates of mouse lung. These results indicate that the effect of protein binding in serum on therapeutic efficacy against intraperitoneal infection differs from that against pulmonary infection.
Psychometric properties of the Activities-Specific Balance Confidence Scale in persons 0–14 days and 3 months post stroke

Purpose: To test the internal consistency and validity of a Swedish translation of the Activities-specific Balance Confidence Scale (ABC) 0–14 days and 3 months post stroke. Method: 37 persons were tested at 0–14 days (median 5 days) post stroke and 31 were retested 3 months later (median 87 days). In addition to the ABC, the Functional Ambulation Categories, modified Rivermead Mobility Index, timed up and go test, 10-meter timed walk, SF-36 and the 12-item Walking Scale were used. Results: The internal consistency was high at α = 0.94 to 0.97. Kendall correlation-τ coefficients were moderate and varied somewhat depending on time poststroke. At 0–14 days post stroke the highest correlation was found between the ABC and the 12-item Walking Scale (−0.55, p < 0.01). At 3 months poststroke, the correlations with the Functional Ambulation Categories was 0.49 (p < 0.01), timed up and go test −0.43 (p < 0.01), 10-meter timed walk −0.41 (p < 0.01), and modified Rivermead Mobility Index 0.46 (p < 0.01). Divergent validity was established by the non-significant correlation (0.12) between the ABC and SF-36 mental component summary. Conclusions: The Swedish version of ABC has high internal consistency and is valid for measuring balance confidence in the acute and sub acute phases of stroke. Implications for Rehabilitation The ABC is a valid measure of balance confidence in persons in the acute and sub acute phases after stroke. A moderate convergent validity was found between the ABC and measures of physical function.
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group.

BACKGROUND To determine whether a restrictive strategy of red-cell transfusion and a liberal strategy produced equivalent results in critically ill patients, we compared the rates of death from all causes at 30 days and the severity of organ dysfunction. METHODS We enrolled 838 critically ill patients with euvolemia after initial treatment who had hemoglobin concentrations of less than 9.0 g per deciliter within 72 hours after admission to the intensive care unit and randomly assigned 418 patients to a restrictive strategy of transfusion, in which red cells were transfused if the hemoglobin concentration dropped below 7.0 g per deciliter and hemoglobin concentrations were maintained at 7.0 to 9.0 g per deciliter, and 420 patients to a liberal strategy, in which transfusions were given when the hemoglobin concentration fell below 10.0 g per deciliter and hemoglobin concentrations were maintained at 10.0 to 12.0 g per deciliter. RESULTS Overall, 30-day mortality was similar in the two groups (18.7 percent vs. 23.3 percent, P= 0.11). However, the rates were significantly lower with the restrictive transfusion strategy among patients who were less acutely ill -- those with an Acute Physiology and Chronic Health Evaluation II score of < or =20 (8.7 percent in the restrictive-strategy group and 16.1 percent in the liberal-strategy group; P=0.03) -- and among patients who were less than 55 years of age (5.7 percent and 13.0 percent, respectively; P=0.02), but not among patients with clinically significant cardiac disease (20.5 percent and 22.9 percent, respectively; P=0.69). The mortality rate during hospitalization was significantly lower in the restrictive-strategy group (22.3 percent vs. 28.1 percent, P=0.05). CONCLUSIONS A restrictive strategy of red-cell transfusion is at least as effective as and possibly superior to a liberal transfusion strategy in critically ill patients, with the possible exception of patients with acute myocardial infarction and unstable angina.
My VM is Lighter (and Safer) than your Container

Containers are in great demand because they are lightweight when compared to virtual machines. On the downside, containers offer weaker isolation than VMs, to the point where people run containers in virtual machines to achieve proper isolation. In this paper, we examine whether there is indeed a strict tradeoff between isolation (VMs) and efficiency (containers). We find that VMs can be as nimble as containers, as long as they are small and the toolstack is fast enough. We achieve lightweight VMs by using unikernels for specialized applications and with Tinyx, a tool that enables creating tailor-made, trimmed-down Linux virtual machines. By themselves, lightweight virtual machines are not enough to ensure good performance since the virtualization control plane (the toolstack) becomes the performance bottleneck. We present LightVM, a new virtualization solution based on Xen that is optimized to offer fast boot-times regardless of the number of active VMs. LightVM features a complete redesign of Xen's control plane, transforming its centralized operation to a distributed one where interactions with the hypervisor are reduced to a minimum. LightVM can boot a VM in 2.3ms, comparable to fork/exec on Linux (1ms), and two orders of magnitude faster than Docker. LightVM can pack thousands of LightVM guests on modest hardware with memory and CPU usage comparable to that of processes.
[Uric acid as a prognostic marker in critically ill patients].

BACKGROUND Elevated uric acid concentrations reflect adenosine triphosphate degradation and suggest poor prognosis since they indicate a cellular bioenergetic crisis. OBJECTIVE To study uric acid concentrations as a prognostic marker of disease severity in critically ill children. PATIENTS AND METHODS Seventy-eight patients admitted to our pediatric intensive care unit with different diseases were prospectively studied. Thirty-five patients with meningococcal infection were retrospectively studied. Data on uric acid concentrations, diagnosis, length of stay, age, weight, the therapeutic intervention scoring system (TISS) and the pediatric risk of mortality score (PRISM) were collected. In patients with meningococcal infection severity was evaluated by studying evolution (death and the presence of sequelae or otherwise). RESULTS Uric acid concentrations on admission were significantly correlated with TISS on the first day (r 0.260; p 0.023) and with PRISM during the first 24 hours (r 0.277; p 0.015). In patients without craniocerebral trauma, correlations between uric acid concentrations and PRISM during the first 24 hours (r 0.524; p < 0.001) and correlations between uric acid concentrations with TISS on day 1 (r 0.483; p < 0.001) and day 2 (r 0.373; p 0.014) improved. In patients with craniocerebral trauma no significant correlations were found between uric acid and any of the other variables. In patients with meningococcal infection, uric acid concentrations on admission were closely related to evolution (uric acid concentrations were 13.20 8.2 mg/dl in patients who died, 8.01 1.77 mg/dl in those with sequelae and 4.72 1.84 mg/dl in in those without sequelae; p < 0.003). CONCLUSIONS Serum uric acid concentrations can be considered as a marker of severity in critically ill patients without craniocerebral trauma and especially in patients with meningococcal infection.
Mechanical left ventricular unloading prior to reperfusion reduces infarct size in a canine infarction model

We tested the hypothesis that unloading the left ventricle just prior to reperfusion provides infarct size reduction compared with left ventricular (LV) unloading postreperfusion and reperfusion alone. Twenty‐four mongrel dogs were subjected to 2 hr of left anterior descending artery occlusion and 4 hr of reperfusion. A transvalvular (TV) left ventricular assist device (LVAD) was inserted just prior to reperfusion and maintained during the rest of the experiment (LV Assist Pre group). In the LV Assist Post group, the TV LVAD was inserted and activated just after reperfusion. A control group was subjected to reperfusion alone with a sham‐TV LVAD. At baseline, the hemodynamic data were similar in the three groups. Myocardial infarct size expressed as percentage of area at risk was significantly reduced in the LV Assist Pre group compared to the control group (P = 0.011) and to the LV Assist Post group (P < 0.05). At 4 hr of reperfusion, transmural myocardial blood flow in the ischemic zone was slightly higher in the animals unloaded prior to reperfusion compared to controls and significantly higher than in the LV Assist Post group (P = 0.04). Postreperfusion end‐diastolic wall thickness returned to baseline level in the TV LV Assist Pre group compared to both controls and TV LV Assist Post group. In these latter two groups, a significant increase in postreperfusion end‐diastolic wall thickness and contraction band necrosis in the central ischemic zone correlated well with the degree of reperfusion injury. LV unloading prior to, but not after, reperfusion reduces the extent of myocardial necrosis in canine hearts subjected to 2 hr of left anterior descending artery occlusion and 4 hr of reperfusion compared to either reperfusion alone or LV unloading after reperfusion. Catheter Cardiovasc Interv 2005;64:182–192. © 2005 Wiley‐Liss, Inc.
Carotid Angioplasty and Stenting in Carotid Artery Stenosis: Neuroscience Nursing Implications

Stenosis of the internal carotid artery due to atherosclerosis can cause embolic stroke or cerebral ischemia, both of which may result in significant morbidity, mortality, and long-term disability. Although the endovascular technique with balloons and stents to relieve arterial (i.e., coronary) stenosis has allowed a nonsurgical approach to the management of atherosclerotic disease for many years, its use in carotid vessels has only recently gained popularity. In addition, improvements in endovascular access systems have extended the use of carotid angioplasty and stenting (CAS), especially since the advent of cerebral emboli protection devices. Nowadays, CAS is emerging as an intervention for high-risk surgical patients with high-grade carotid artery stenosis. Nursing care of these patients before, during, and after CAS is challenging. Patients and family need to be educated about the aim and consequences of the procedure and its complications. To care for these patients, the nurse must understand the techniques of CAS. The purpose of this article was briefly to review the etiology of stroke, the current treatments to relieve carotid stenosis, and the basic steps of CAS. The nursing management throughout the procedure, the patient preparation before the procedure, and most importantly, the postprocedure nursing care are discussed.
Second Harmonic Treatment Technique for Bandwidth Enhancement of GaN HEMT Amplifier With Harmonic Reactive Terminations

Source and load impedance conditions for the second harmonics have a great influence on the efficiency of amplifiers. The bandwidth of high-efficiency operation is limited, since efficiency is drastically degraded due to a slight change in source-side second harmonic impedance from the optimum point. For this reason, to avoid steep efficiency degradation, a source-side second harmonic impedance control is introduced. In addition, a harmonic treatment network, which reduces the influence on matching-network design, is also described here. A fabricated GaN HEMT amplifier has achieved a maximum power-added efficiency (PAE) of 79% with a saturated output power of 48.0 dBm at 2.02 GHz. The amplifier has also achieved a high-efficiency characteristic of more than 70% PAE in the frequency range from 1.68 to 2.12 GHz.
Generalized hopping model for frequency-dependent transport in a dynamically disordered medium, with applications to polymer solid electrolytes.

Protonic diffusion in hydrogen-bonded networks, ionic conduction in polymeric solid electrolytes, and other processes in which the carrier transport mechanism involves motion of the host medium on a time scale comparable to that of the carrier motion itself require generalization of the usual models based on carrier hopping in a static medium. Under the assumption that this concurrent motion of the host can be modeled by a random reassignment (or ``renewal'') of hopping probabilities, with a constant probability \ensuremath{\lambda} per unit time for renewal to occur, the effects of host motion on the frequency-dependent diffusion coefficient D(\ensuremath{\omega}) are now considered. We consider both the dynamic bond-percolation model (in which the site-to-site hopping probability is randomly assigned either the value w or the value 0) and the more general model based on a possibly continuous distribution of hopping rates randomly assigned between different pairs of sites. Under these assumptions, the diffusion coefficient D(\ensuremath{\omega}) with renewal is shown to be obtainable from D(\ensuremath{\omega}) without renewal through the formal substitution i\ensuremath{\omega}\ensuremath{\rightarrow}\ensuremath{\lambda}+i\ensuremath{\omega}. For the \ensuremath{\omega}=0 limit, an expression is obtained for the time-dependent mean-square displacement with renewal in terms of the mean-square displacement without renewal. These general formal results are applied to the one-dimensional dynamic percolation model, for which specific exact analytic results are thereby obtained, and D(\ensuremath{\omega}) is calculated and studied for this case.