Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictors of postoperative diffuse intrahepatic recurrence of hepatocellular carcinoma.

BACKGROUND/AIMS Diffuse intrahepatic recurrence of hepatocellular carcinoma in the liver remnant carries an extremely poor prognosis compared with other recurrence patterns. We studied the predictors of this type of recurrence. METHODOLOGY We determined the risk factors for recurrence and predictors of long-term post-recurrence survival using the Cox's proportional hazard model. We divided 106 patients with recurrent intrahepatic hepatocellular carcinoma into 3 groups based on the number of nodules, and compared clinicopathologic features to determine which risk factors were associated with the diffuse intrahepatic recurrence pattern. RESULTS An elevated alpha-fetoprotein concentration, invasive nodular- or massive-type hepatocellular carcinoma, intrahepatic metastasis, the presence of macroscopic ductal invasion, and the lack of a capsule predict diffuse intrahepatic pattern of recurrence. Patients who have three or more of these five factors, are poor candidates for hepatic resection because the likelihood of diffuse intrahepatic recurrence is great, and post-recurrence survival is worse than that with solitary or multiple intrahepatic recurrence. CONCLUSIONS It is possible to reduce the risks of cancer recurrence at the time of primary resection. It is important to predict the pattern of early diffuse intrahepatic recurrence. In candidates with a poor prognosis, adjuvant therapy or transplantation should be considered.
Upregulation of translational machinery and distinct genetic subgroups characterise hyperdiploidy in multiple myeloma

Karyotypic instability, including numerical and structural chromosomal aberrations, represents a distinct feature of multiple myeloma (MM). About 40–50% of patients display hyperdiploidy, defined by recurrent trisomies of non‐random chromosomes. To molecularly characterise hyperdiploid (H) and nonhyperdiploid (NH) MM, we analysed the gene expression profiles of 66 primary tumours, and used fluorescence in situ hybridisation to investigate the major chromosomal alterations. The differential expression of 225 genes mainly involved in protein biosynthesis, transcriptional machinery and oxidative phosphorylation distinguished the 28 H‐MM from the 38 NH‐MM cases. The 204 upregulated genes in H‐MM mapped mainly to the chromosomes involved in hyperdiploidy, and the 29% upregulated genes in NH‐MM mapped to 16q. The identified transcriptional fingerprint was robustly validated on a publicly available gene expression dataset of 64 MM cases; and the global expression modulation of regions on the chromosomes involved in hyperdiploidy was verified using a self‐developed non‐parametric statistical method. H‐MM could be further divided into two distinct molecular and transcriptional entities, characterised by the presence of trisomy 11 and 1q‐extracopies/chromosome 13 deletion respectively. These data reinforce the importance of combining molecular cytogenetics and gene expression profiling to define a genomic framework for the study of MM pathogenesis and clinical management.
Psychological Aspects of Rape and Its Consequences

Sexual violence is defined as “Any sexual act, attempt to obtain a sexual act, unwanted sexual comments or advances, or acts to traffic, or otherwise directed, against a person’s sexuality using coercion, by any person regardless of their relationship to the victim, in any setting, including but not limited to home and work” [1]. Sexual assault is any form of sexual contact without voluntary consent and that violates a person’s sense of autonomy, control and mastery over their body. Unwanted sexual experiences are often measured along a continuum, including categories of unwanted sexual contact (e.g., kissing or fondling), verbal coercion, attempted rape, and rape, presumed to reflect the least to most severe experiences. Different methods of coercion: arguments and pressure, misuse of authority, alcohol or drug intoxication (separate questions for attempted and completed acts), and physical force used by the perpetrator has been conceptualized to vary in extent of trauma perceived [2]. Another distinction was attempted on the basis of forcible and incapacitated rape. In forcible rapes more force is used by the perpetrator due to which more resistance is offered by the victim resulting in more injuries [3]. During forcible rapes the victim shows more physical symptoms of stress including shortness of breath, rapid heart rate, and sweating, than during incapacitated rapes [4]. While forcible and incapacitated rapes differ in the degree of physical trauma involved, they may not differ with regard to emotional trauma. Based on these severities and distinctions the psychological consequences may vary [5].
Model-free fuzzy control of twin rotor aerodynamic systems

This paper suggests data-driven Model-Free Control (MFC) algorithms based on the combination of Takagi-Sugeno fuzzy (TSF) and intelligent proportional-integral (iPI) controllers. The new MFC algorithms are referred to as mixed TSF-iPI controllers, which are designed to control Single Input-Single Output (SISO) control structures for azimuth and pitch position control of a nonlinear twin rotor aerodynamic system (TRAS). The mixed TSF-iPI controllers are designed by fuzzifying the proportional-derivative term in the iPI controller structure. The performance of the SISO control structures with mixed TSF-iPI controllers and iPI controllers is compared by means of real-time experiments conducted on a TRAS laboratory equipment using controllers tuned in terms of a metaheuristic Gravitational Search Algorithm optimizer.
Potential benefits of the UK Cystic Fibrosis Database.

Cystic fibrosis (CF) is a complex condition involving genetic, nutritional, inflammatory, pulmonary, gastroenterological, psychological, renal, rheumatological and obstetric complications that arises in a quarter of the offspring from a population of around 2.4 million randomly distributed carriers in the UK. Over the last decade, a generic approach to track the progress of this chronic disease has been established by a multidisciplinary team of clinicians, paramedical staff, computer specialists and experienced clinical data entry personnel at the University of Dundee (see www.cystic-fibrosis.org.uk). The resultant UK CF Database (UKCFD) currently runs within specialist CF clinics in over 65 UK hospitals and aims to facilitate patient care, audit and research by providing customized software to each clinical team after appropriate training. The hypothesis underpinning our approach was that robust software design1,2 could standardize patient care while the resulting multicentre dataset would facilitate local, regional and national audit as well as cross-sectional and longitudinal research. As numbers of CF patients on the database have continued to increase with over 92% of the estimated 7500 patients3 from all the specialist CF Centres across the UK now registered, these benefits to the CF community are beginning to accrue. The software within the UKCFD produces graphical output, and an example showing the age profile of the CF population registered with the database by the end of 2002 is illustrated in Figure 1. Progress in CF care is illustrated by increasing numbers of adults and longevity into old age in some countries. When such survival is common-place, it is anticipated that there will be over 20 000 CF patients in the UK, approximately 3 times the current population.3,4
Predictor of response to salvage radiotherapy in patients with PSA recurrence after radical prostatectomy: the usefulness of PSA doubling time.

BACKGROUND We assessed predictors of response to salvage radiotherapy (sRT) in patients with prostate-specific antigen (PSA) recurrence after radical prostatectomy. METHODS A total of 21 patients receiving sRT for PSA recurrence without systemic progression after radical prostatectomy had medical records available for retrospective review. We defined sRT as external beam radiotherapy for patients with a continuous increase in PSA level > or =0.2 ng/ml after radical prostatectomy. Response was defined as achievement of a PSA nadir of < or =0.1 ng/ml. Various pre-treatment parameters were evaluated retrospectively. RESULTS The median follow-up period after sRT was 38 months. Of the 21 patients, 15 were good responders (71%). The only predictive factor was PSA doubling time (PSADT). Age and PSA level at diagnosis, Gleason score and surgical margin status were not significant predictors of response. The median PSADT in responders was 6.2 months versus 1.9 months in non-responders (P = 0.019). The patients with a PSADT of > or =5 months were all responders. CONCLUSION PSADT appears to be a good predictor of response to sRT. sRT was especially effective when PSADT was > or =5 months.
Gender stereotypes stem from the distribution of women and men into social roles

According to stereotypic beliefs about the sexes, women are more communal (selfless and concerned with others) and less agentic (self-assertive and motivated to master) than men. These beliefs were hypothesized to stem from perceivers' observations of women and men in differing social roles: (a) Women are more likely than men to hold positions of lower status and authority, and (b) women are more likely than men to be homemakers and are less likely to be employed in the paid work force. Experiments 1 and 2 failed to support the hypothesis that observed sex differences in status underlie belief in female communal qualities and male agentic qualities. Experiment 3 supported the hypothesis that observed sex differences in distribution into homemaker and employee occupational roles account for these beliefs. In this experiment, subjects perceived the average woman and man stereotypically. Female and male homemakers were perceived as high in communion and low in agency. Female and male employees were perceived as low in communion and high in agency, although female employees were perceived as even more agentic than their male counterparts. Experiments 4 and 5 examined perceptions that might account for the belief that employed women are especially agentic: (a) A double burden of employment plus family responsibilities did not account for this belief, and (b) freedom of choice about being employed accounted for it reasonably well.
High Manifestations of Mental Distress in Arabic Asylum Seekers Accommodated in Collective Centers for Refugees in Germany

The number of asylum seekers in Germany has significantly increased in the last two years. Coming from regions of political conflict and war, the refugees have often experienced traumatic events which designate them as a high risk group for mental disorders. In a sample of Arabic speaking asylum seekers in collective accommodation centers in Erlangen, Germany, we estimated the extent of posttraumatic stress, depression, and anxiety. A further objective of the study was to test the comprehensibility and cultural appropriateness of the Arabic translations of the questionnaires in this sample. Between August and September 2016, 56 Arabic speaking asylum seekers placed among three collective accommodation centers in Erlangen completed self-report questionnaires assessing posttraumatic stress disorder (Essen Trauma-Inventory, ETI), and symptoms of depression (Patient Health Questionnaire—depression module, PHQ-9) and anxiety (Generalized Anxiety Disorder, GAD-7). The prevalence of participants with personally and/or witnessed traumatic events was 80.4% (n = 45). About one-third of the examinees (35.7%, n = 20) endorsed symptoms of PTSD (posttraumatic stress disorder). The total score for depression in this sample was M = 11.9 (SD = 7.9, range: 0–27). Moderate to severe depression (PHQ-9 score ≥ 15) was found in 35.7% (n = 20) of our sample and severe depression (PHQ-9 score ≥ 20) was found in 23.2% (n = 13). The total score for anxiety was M = 8.8 (SD = 6.9, range: 0–21), with 26.8% (n = 15) of the sample showing symptoms of severe anxiety (GAD-7 score ≥ 15). No significant difference between women and men with respect to frequency and symptom scores of PTSD, depression, and anxiety was found. Amongst asylum seekers of the presented sample, the rates of traumatic events as well as the prevalence of possible PTSD, depression, and anxiety were significantly higher than in the German population. This indicates that the refugee population is in need of culturally sensitive psychological interventions. However, more studies are required to improve the understanding of mental health among this particularly vulnerable population.
The “Cross” Signs in Patients With Multiple System Atrophy: A Quantitative Study

Patients with multiple system atrophy (MSA) may show the “cross” sign in the pontine base that has been considered as an expression of the degeneration of pontine neurons and transverse pontocerebellar fibers. However, correlations between pontine base atrophy and existence of “cross” sign have not been fully investigated. The authors studied 68 patients with MSA (47 MSA‐C [predominantly cerebellar ataxia], 21 MSA‐P [predominantly parkinsonism], mean [±SD ] 58.7 ± 10.9 years). T1‐weighted (T1W) sagittal and axial images and T2‐weighted (T2W) axial images were obtained for all patients and controls. To measure the areas of pontine basis and cerebellar vermis, the authors used midsagittal T1W images and analyzed a bit map transformed on a computer. They classified atrophy in the pontine base into 3 grades. There is significant correlation between atrophies of pontine base and existence of the cross sign. All patients with a smaller area of pontine base 2 standard deviations below those of normal controls had the cross sign. This supports that existence of the cross sign depends only on the extent of pontine base atrophies.
Follicular fluid composition of ovulatory follicles in repeat breeder Holstein dairy cows

Objective: To examine differences in the metabolite, steroid and lipopolysaccharide of follicular fluid collected from the ovulatory follicle of Holstein repeat breeding cows, lactating cows, and virgin fertile heifers. Methods: Estrus was induced in animals possessing functional corpus luteum by intramuscular administration of prostaglandin F2 α. Six to twelve hours after detection of the standing estrus, cervical samples were collected to detect subclinical endometritis via counting neutrophils on stained smears of cervical swabs. Then, follicular fluid of ovulatory follicles and serum samples were collected from repeat breeding cows (n=11), lactating cows (n=8) and virgin fertile heifers (n=10). Sodium and potassium were measured with a flame photometer method. Urea, total protein, glucose, cholesterol and β -hydroxybutyric acid were assayed with commercial spectrophotometry kits. Chloride concentration was also measured with titration of samples against silver nitrate. Progesterone, estradiol-17 β and lipopolysaccharide concentrations were measured using enzyme-linked immuno sorbent assay kits. Results: All analysis of follicular fluid samples showed that repeat breeding and lactating cows had a mean higher lipopolysaccharide concentration than that of the virgin fertile heifers (P<0.05). But concentration of serum estradiol-17 β in repeat breeding and lactating cows was lower than that of virgin fertile heifers (P<0.05). In addition, the mean percentage of neutrophils in the cervical secretion of repeat breeding cows was higher than that of lactating cows (P<0.05). Conclusions: High follicular fluid concentration of lipopolysaccharide in ovulatory follicles results in the occurrence of repeat breeding syndrome in dairy cows. Further, a lower serum estradiol-17 β concentration and a higher percentage of neutrophil in the cervical secretion on the day of artificial insemination may have resulted in the occurrence of repeat breeding syndrome in dairy cows.
RATS MADE CIRRHOTIC BY CHRONIC CCl4 TREATMENT STILL EXHIBIT ANTICIPATORY ACTIVITY TO A RESTRICTED FEEDING SCHEDULE

Food entrainment of clock genes in the liver suggests that this organ may underlie a food entrained oscillator (FEO), which manifests under restricted feeding schedule (RFS). In order to test the importance of a functional liver for the expression of FEO, chronic CCl4-treated cirrhotic rats and oil-treated controls were entrained to RFS and drinking behavior was continuously monitored. After 20 d of free-running conditions, food access was restricted to 2 h, followed by a refeeding–fasting protocol to test persistence of anticipatory drinking. Present data show no differences between groups for the onset and intensity of anticipation during RFS. After RFS, however, cirrhotic rats exhibited a significantly longer free-running period and a delay and lower intensity of the persistence of activity under fasting conditions. Histology confirmed injury of the liver chronically treated with CCl4. Present data indicate that a dysfunctional liver due to chronic CCl4 does not prevent animals from exhibiting anticipatory activity but may promote metabolic derangement of the clock mechanisms of the suprachiasmatic nucleus and the FEO.
Allergic contact dermatitis to methyl aminolevulinate after photodynamic therapy in 9 patients

This report describes 9 patients who developed allergic contact dermatitis to methyl aminolevulinate used for photodynamic therapy (PDT). The risk of developing contact allergy to methyl aminolevulinate in PDT treated patients was calculated to 1% after an average of 7 treatments (range 2–21).
A Multi-task Framework for Monitoring Health Conditions via Attention-based Recurrent Neural Networks

Monitoring the future health status of patients from the historical Electronic Health Record (EHR) is a core research topic in predictive healthcare. The most important challenges are to model the temporality of sequential EHR data and to interpret the prediction results. In order to reduce the future risk of diseases, we propose a multi-task framework that can monitor the multiple status ofdiagnoses. Patients' historical records are directly fed into a Recurrent Neural Network (RNN) which memorizes all the past visit information, and then a task-specific layer is trained to predict multiple diagnoses. Moreover, three attention mechanisms for RNNs are introduced to measure the relationships between past visits and current status. Experimental results show that the proposed attention-based RNNs can significantly improve the prediction accuracy compared to widely used approaches. With the attention mechanisms, the proposed framework is able to identify the visit information which is important to the final prediction.
Proteins Specified by Herpes Simplex Virus X. Staining and Radiolabeling Properties of B Capsid and Virion Proteins in Polyacrylamide Gels

Analyses of the structural proteins of herpes simplex virions and of capsids containing viral DNA (B capsids), after electrophoresis in polyacrylamide gels, revealed considerable variability in their properties with respect to: (i) retention of Coomassie brilliant blue (CBB) and fast green stains during destaining, (ii) relative optical absorbance of the CBB-protein complex at different wavelengths, (iii) relative efficiency with which 14C-amino acids are incorporated during early and late periods of the infection cycle, and (iv) capacity to be phosphorylated in vivo. In addition, it was found that protein 22a of B capsids, which does not have an electrophoretically identical counterpart in virions, shares a relatively unique set of staining and radiolabeling properties with virion protein 22, which has a slightly more rapid electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gels.
Clustering Documents using the 3-Gram Graph Representation Model

In this paper we illustrate an innovative clustering method of documents using the 3-Gram graphs representation model and deducing the problem of document clustering to graph partitioning. For the latter we employ the kernel k-means algorithm. We evaluated the proposed method using the Test Collections of Reuters-21578, and compared the results using the Latent Dirichlet Allocation (LDA) Algorithm. The results are encouraging demonstrating that the 3-Gram graph method has much better Recall and F1 score but worse Precision. Further changes that will further improve the results are identified.
A comparison of the diagnostic value of 2D strain stress echocardiography, myocardial perfusion scintigraphy, and Duke treadmill score in patients suspected of coronary artery disease

Preinvasive risk stratification is recommended in patients suspected of coronary artery disease (CAD). Stress echocardiography (SE), myocardial perfusion scintigraphy (MPS), and exercise test are the dominant methods of choice. Vasodilator SE is fast and induces only minor increase in heart rate. The diagnostic value of the absolute stress–rest difference in endocardial global longitudinal strain (ΔeGLS) and wall motion (ΔWMI) from adenosine SE was compared to summed stress score (SSS) from MPS and Duke treadmill score (DTS) from exercise test, using quantitative invasive coronary angiography (ICA) as the reference.
Design and Development of a Novel Compliant Gripper With Integrated Position and Grasping/Interaction Force Sensing

This paper proposes a new compliant gripper with integrated position and force sensors dedicated to automated microassembly tasks. The uniqueness of the gripper is that it possesses a large gripping range with a bidirectional drive, and it is capable of detecting grasping force and environmental interaction forces in horizonal and vertical axes, respectively. This is enabled by a mechanism design based on a rotary flexure bearing. Moreover, a compliant mechanism with two-stage stiffness is designed to provide the force sensing with dual sensitivities and measuring ranges to accommodate the grasp of objects with different sizes and weights. Analytical models are derived to predict the grasping range, force sensing sensitivities, and ranges. These models are verified by conducting finite-element analysis simulations. A proof-of-concept prototype gripper is developed for experimental calibration and performance testing. Results reveal that the single set of strain-gauge force sensor is able to detect both grasping and interaction forces in an alternate manner. The dual-sensitivity, dual-range force sensor provides a solution to large-range gripper with finer and coarser force sensing in a small and large ranges, respectively .