Miracle-dz/UniFAR-FTUs huggingface dataset:
Responsabilidad social y ética administrativa empresarial

This research aims to make a conceptual analysis of Corporate Social Responsibility and its explicit relationship with management in the ethical field as a foundation of the corporate image of MABE, for its characteristics, mission, and vision that represents a social function and a Transcendent end is very important for MABE. For this reason, it is made a historical tour of the concept and its different meanings over time to understand its essentiality in the corporate practices and organizations of the company, the method is hermeneutic and interpretative. Nowadays, in our managerial role, business leaders are looking for various tools to find the magic key that opens the door to business success. That is when every proposal that probvides innovation becomes important. As a result, the innumerable existing methods for management decision-making that in many cases provide the tools necessary to take various roads toward proper decision-making using the orderly and systematic application of a process. This leads to the realization of various activities with the purpose of identifying and solving problems related to social responsibility. Investing in administrative ethics would be a lower cost compared to the high profits that would be obtained because it is the ideal tool for every manager. Human organizational success is vital for the business’ direction because it has the sole aim of guiding the course of the business to prioritize human investment. The objective of ethical management is to provide well-being to the employees which will provide more resources to the company and thus jointly support the responsible decision-making by maintaining a respectful conduct of ethical legality, morality, and commitment to the environment. This is essential because is about the balance between the company, the man, and the environment "eco-efficiency" (reduction of the environmental impact in relation to the volume of production obtained). This important step is necessary in all organizations and the many advantages are clearly proven that human management is committed to the environment and the well-being of its employees.
Lower Prevalence of the OCT2 Ser270 Allele in Patients with Essential Hypertension

Impairment of the renal dopaminergic pathway has been shown to result in essential hypertension. The Organic Cation Transporter 2, OCT2 (SLC22A2), has been implicated in renal dopamine handling as well as in the inactivation of circulating catecholamines and is supposed to be involved in blood pressure regulation. This study investigated the association of the OCT2 Ala270Ser polymorphism with essential hypertension and its impact on blood pressure status in 607 Caucasian patients who underwent left heart catheterization. Clinical characteristics and diagnosis were recorded and blood pressure was determined by intravascular measurement. A comparison of genotypes revealed that patients with the Ser270 allele were less frequently affected by the clinical diagnosis of hypertension than homozygous carriers of the wild type allele Ala270 (Kruskal Wallis test, p = 0.028). This relation was even more pronounced in the subgroup of patients without diabetes mellitus (Kruskal Wallis test, p = 0.013). In summary, the first data on OCT2 are presented in the context of a candidate gene analysis. The Ala270Ser polymorphism was significantly associated with essential hypertension in the present sample. This study further suggests a function of OCT2 in blood pressure homeostasis and points to the potential role of the transporter in the development of essential hypertension.
Hey, you, keep away from my device: remotely implanting a virus expeller to defeat Mirai on IoT devices

Mirai is botnet which targets out-of-date Internet-of-Things (IoT) devices. The disruptive Distributed Denial of Service (DDoS) attack last year has hit major Internet companies, causing intermittent service for millions of Internet users. Since the affected devices typically do not support firmware update, it becomes challenging to expel these vulnerable devices in the wild. Both industry and academia have made great efforts in amending the situation. However, none of these efforts is simple to deploy, and at the same time effective in solving the problem. In this work, we design a collaborative defense strategy to tackle Mirai. Our key idea is to take advantage of human involvement in the least aggressive way. In particular, at a negotiated time slot, a customer is required to reboot the compromised device, then a "white" Mirai operated by the manufacturer breaks into the clean-state IoT devices immediately. The "white" Mirai expels other malicious Mirai variants, blocks vulnerable ports, and keeps a heart-beat connection with the server operated by the manufacturer. Once the heart-beat is lost, the server re-implants the "white" Mirai instantly. We have implemented a full prototype of the designed system, and the results show that our system can evade Mirai attacks effectively.
The Political and Economic Determinants of Health Outcomes: A Cross-National Analysis

This article investigates the impact of selected political and economic processes on the well-being of domestic populations within samples of 50 to 84 peripheral and noncore nations. Existing research by Cereseto and Waitzkin on the relative merits of market versus socialist systems for the provision of health and welfare needs of their populations is extended by employing a more complex model than the original study. More specifically, the authors assess the impact on measures of population health and mortality rates of regime ideology, state strength, multinational corporate penetration, and position in the world economy. In general, high levels of democracy and strong left-wing regimes are associated with positive health outcomes, and strong right-wing regimes have populations with lower life expectancies and higher levels of various measures of mortality. These findings support the conclusion that political systems make a difference in health and well-being independent of national (gross national product per capita) and international (investment dependency) economic factors.
A survey of cervical screening among refugee and non‐refugee African immigrant women in Brisbane, Australia

Issue addressed To compare the level of cervical screening uptake between refugee and non-refugee African immigrant women living in Brisbane, Australia, and examine factors associated with Pap smear testing. Methods Cross-sectional survey with a convenience sample of 254 women aged 21-62 years from 22 African countries (144 refugees, 110 non-refugees). Chi-square tests were used to compare the demographic and health-related characteristics between refugee and non-refugee women. Bivariate and multiple logistic regression analyses were used to assess the relationship between the outcome variable (Pap smear testing) and the independent variables. Results Two-thirds of women had used Pap smear services in Australia. Chi-square test analysis established that non-refugee women were significantly more likely to have used Pap smear services than refugee women (73.6% vs 61.8% respectively; P=0.047). Immigration status, however, was not a significant predictor of cervical screening uptake in the multiple regression analyses. The significant predictors for screening uptake in these analyses were work arrangement, parity, healthcare visit, knowledge about Pap smear and perceived susceptibility to cervical cancer. Conclusion Most women relied on opportunistic screening after receiving invitation letters to screen or after visiting health professionals for antenatal or postnatal care. So what? The findings suggest that organised cervical screening programs are not reaching most African immigrant women living in Brisbane. It is incumbent on the public health sector, including healthcare professionals and settlement agencies working with African communities, to develop health promotion strategies that meaningfully engage African immigrant women, including those from refugee backgrounds, to enhance their knowledge about cervical cancer and screening practices.
Johannes Althusius' Grand Federalism, the Role of the Ephors and Post-Statist Constitutionalism

This article discusses the primary structures Johannes Althusius’ constitutionalism, as explained in his Politica: Politics Methodically Set Forth and Illustrated with Sacred and Profane Examples published in 1603. The first of these structures and the theme that Althusius is most famous for, is his scheme of grand republican federalism. The second is the public office of the ephors. The discussion is not primarily historical, however. The main aim, instead, is to assess the potential relevance of Althusius’ thinking for present-day constitutionalism. After centuries of at best scant relevance owing to the dominance of the statist paradigm in constitutional doctrine and practice, the decline of this paradigm is now creating considerable new interest in Althusius’ thinking. The discussion starts off with a concise account of the statist paradigm, which was at its advent in Althusius’ days. Thereafter follows an exposition of his federalism which consists of a set of associations, beginning with the closest-knit association, namely the family, spiralling out into the most encompassing association, which is the commonwealth or realm, with collegia, cities and provinces in between. The office of the supreme magistrate is dealt with under this heading. This discussion also focusses pertinently on the question of sovereignty, which in Althusian conceptualisation was a diffuse popular sovereignty in contrast to that of his statist opponents, more specifically Jean Bodin, and in posterity, Thomas Hobbes. Then follows an assessment of the public office of the (council of the) ephors, which assists the supreme magistrate in executing his responsibilities in accordance with the law and the covenant between the commonwealth and the magistrate and serves a as counterbalance of authority and power against the sovereign. Against this backdrop Althusius’ constitutional thinking is evaluated. First, his constitutionalism is placed in historical context in contrast to (1) classical polis-based thought; (2) medieval imperial thinking and (3) modern statist constitutionalism. Secondly, Althusius’ communitarian anthropology, which is in part the basis for his federalism, and which constitutes an anticipatory response to liberal individualism is assessed. Lastly it is argued that Althusius’ federalism provides a valuable source for improving on the state-departmentalisation of power separation and checks and balances, currently still sway in terms of the statist paradigm.
A review of chemical agents in the pharmacotherapy of addiction.

Chemical substance abuse has tormented mankind throughout history. A number of chemical approaches have been employed in an attempt to treat chemical addiction. Unfortunately, most of these have proven unsuccessful though several chemical entities have been shown to be moderately effective. The naturally occurring alkaloid ibogaine has been reported to interrupt the cravings for alcohol, cocaine and opiates. Other alkaloids from Tabernanthe iboga, such as ibogamine and tabernanthine, provide insight into the structure activity relationship at the different receptors believed to be involved in addiction. The synthetic iboga alkaloid congener, 18-MC, also shows potential as an anti-addictive agent without the hallucinogenic effects of ibogaine. Additionally, acamprosate, BP 897, GBR12909, lofexidine and memantine have shown promising results in the treatment of addiction. All of these leads provide a start for the medicinal chemist to design anti-addictive agents, since currently no drugs are approved in the U.S. for the treatment of addictions to cocaine, methamphetamine, other stimulants or PCP.
Toddler Democracy and a Typical Governance in Guinea-Bissau

This paper evolves from the beginning of the democratization process which culminated with the formation of political parties and analyzed the functioning of political parties by observing the practice on democracy and governance system in much more contextualized and corresponding terms from 1991 to 2017. The paper explores the relationships between the political system and the constitution as against the transgression of constitutional power as source of conflicts. The paper also examined carefully the roles of political parties, the media and civil society in democratization process. The paper found that there are inversion of values and mis-concept of democracy, political leaders deviate from key democratic principles and there is a group of political elites addicted to power that have been resorting the political fraud to control power which is complicating democratic progress. In order to forestall the ugly trend, the paper recommends that political leaders and elites should lead the country with wisdom. Elected leaders should be people who are ready to fight tirelessly and positively contribute to building and developing society.
Porcine endogenous retrovirus and other viruses in xenotransplantation

Purpose of reviewPotential transmission of zoonotic porcine viruses is a major safety issue in xenotransplantation. This review will first summarize recent studies involving transmission and control of the major concern, porcine endogenous retrovirus (PERV). Second, the potential for zoonotic transfer and safety measures required against other viruses of concern will be discussed. Recent findingsAs studies on PERV genomics continue, distribution of PERV, particularly porcine endogenous retrovirus-C in individual pigs in relation to their ability to transmit PERV in vitro, is becoming clearer. However, further study is required to establish pig lines devoid of problematic copies of PERV. As an extra level of safety, several strategies have been sought, with some success, to reduce PERV infectivity and be used to produce transgenic, PERV-suppressed pigs. Porcine herpesviruses, hepatitis E virus, arenaviruses and an Anellovirus, Torque teno virus, have been highlighted as other viruses of potential risk. SummaryXenotransplantation is a unique situation in which pathogen monitoring may be required to be more comprehensive than that required for specific pathogen-free sources. With evidence of transmission of novel viruses via allotransplantation, significant attention should be paid to emerging and as yet unknown viruses.
PRIDE: Data Submission and Analysis

The Proteomics Identifications database (PRIDE, http://www.ebi.ac.uk/pride) is one of the main repositories designed to store, disseminate, and analyze mass spectrometry–based proteomics datasets. In this unit, an overview of the PRIDE system is given, including its key satellite tools: the Ontology Lookup Service (OLS), the Protein Identifier Cross‐Referencing Service (PICR), and Database on Demand (DoD). Also described in detail are procedures for submitting data to PRIDE, and accessing data stored in PRIDE using the BioMart interface. Finally, to demonstrate the potential of PRIDE as a source for data mining, an example protocol is provided to showcase the powerful cross‐domain query capabilities available through a combination of BioMarts. Curr. Protoc. Protein Sci. 60:25.4. 1‐25.4. 11. © 2010 by John Wiley & Sons, Inc.
Modulation of oral tolerance to ovalbumin by cholera toxin and its B subunit

Oral administration to mice of ovalbumin (OVA), if given together with cholera toxin (CT) or its B subunit (CTB) prevented the hyporesponsiveness to OVA subsequently injected parenterally. Oral immunization with CT plus OVA or OVA plus CTB in fact primed the immune system, inducing a stronger response to a subsequent parenteral injection of OVA with complete Freund's adjuvant than in mice prefed only with OVA or with saline. Oral CT plus OVA also induced good serum IgG1 and IgA anti‐OVA responses, with slightly (not significant) decreased IgG2a and IgG2b responses. Our in vivo findings agree well with earlier in vitro data from others, including CT inhibition of the Th1 CD4+ T cell subset and with CT effect on B cells (induction of LPS‐stimulated IgM+ B cells to undergo increased switch differentiation to IgG1‐ and IgA‐secreting cells).
Actin Directly Interacts with Phospholipase D, Inhibiting Its Activity*

Mammalian phospholipase D (PLD) plays a key role in several signal transduction pathways and is involved in many diverse functions. To elucidate the complex molecular regulation of PLD, we investigated PLD-binding proteins obtained from rat brain extract. Here we report that a 43-kDa protein in the rat brain, β-actin, acts as a major PLD2 direct-binding protein as revealed by peptide mass fingerprinting in combination with matrix-assisted laser desorption ionization/time-of-flight mass spectrometry. We also determined that the region between amino acids 613 and 723 of PLD2 is required for the direct binding of β-actin, using bacterially expressed glutathione S-transferase fusion proteins of PLD2 fragments. Intriguingly, purified β-actin potently inhibited both phosphatidylinositol-4,5-bisphosphate- and oleate-dependent PLD2 activities in a concentration-dependent manner (IC50 = 5 nm). In a previous paper, we reported that α-actinin inhibited PLD2 activity in an interaction-dependent and an ADP-ribosylation factor 1 (ARF1)-reversible manner (Park, J. B., Kim, J. H., Kim, Y., Ha, S. H., Kim, J. H., Yoo, J.-S., Du, G., Frohman, M. A., Suh, P.-G., and Ryu, S. H. (2000) J. Biol. Chem. 275, 21295–21301). In vitro binding analyses showed that β-actin could displace α-actinin binding to PLD2, demonstrating independent interaction between cytoskeletal proteins and PLD2. Furthermore, ARF1 could steer the PLD2 activity in a positive direction regardless of the inhibitory effect of β-actin on PLD2. We also observed that β-actin regulates PLD1 and PLD2 with similar binding and inhibitory potencies. Immunocytochemical and co-immunoprecipitation studies demonstrated the in vivointeraction between the two PLD isozymes and actin in cells. Taken together, these results suggest that the regulation of PLD by cytoskeletal proteins, β-actin and α-actinin, and ARF1 may play an important role in cytoskeleton-related PLD functions.
2017-18 Guide for Participants: Virginia Commonwealth University Peer Mentoring Program

The Peer Mentoring Program Guide for Participants provides information for both university faculty mentees and their faculty mentors to help establish and develop a productive mentoring relationship. This Guide is the handbook for the Virginia Commonwealth University Peer Mentoring Program, which seeks to support early career faculty members, enabling them to succeed and thrive in the academy as both scholars and educators. The VCU Peer Mentoring program is part of the VCU Office of Faculty Affairs.
Data collection maximization of EH-WSN using mobile sink

In this paper a novel approach of data collection using mobile sink is considered for energy harvesting wireless sensor network. Data collection through mobile sink conserves the fast depletion of energy so energy hole problem can be reduced by using this. Sensor are powered by energy renewable resources and depleted along a path. Whenever we design a network, time varying characteristics of EH poses a great challenge. So in this paper we formulate a network that deals with multi-rate transmission and parallel transmission-time scheduling. So for real distributive network where each sensor has different transmission power, an independent component gauss seidel algorithm (ICGS) is devised for the optimal path selection and data selection. In addition a special case is also considered where each sensor has same transmission power. We finally conduct extensive experiments by simulation in MATLAB, to evaluate the performance of the algorithm.
Telomeric 22q13 deletions resulting from rings, simple deletions, and translocations: cytogenetic, molecular, and clinical analyses of 32 new observations

The terminal regions of human chromosomes are known to contain specialised DNA sequences and may be vulnerable to rearrangements causing human genetic diseases and particularly idiopathic mental impairment.1,2 During the last decade, there have been several reports of patients who are described as having a 22q13 monosomy resulting from simple terminal deletions.1,3–11 A common phenotype emerged from these reports, including variable learning difficulties with disproportionate verbal delay, generalised hypotonia, normal to accelerated growth, and minor facial dysmorphy.10 Monosomies for 22q13 have also been reported that result from unbalanced translocation with an acrocentric short arm.10,12 The acrocentric short arms only bear ribosomal genes, and their duplication or deletion is not generally thought to be phenotypically significant. Therefore such translocations can be considered as “pure” terminal 22q13 deletions. A distinct group of 22q13 monosomies has been reported that result from the formation of a ring chromosome which combines loss of some long arm material with loss of part of the short arm, with no clinical consequences. Nevertheless, although ring chromosome 22 has been described in over 50 cases,13 it remains uncertain whether the variable phenotype is caused by the loss of a variable amount of chromosomal material or by a cellular mosaicism arising from instability of the ring. Regardless of the causative rearrangement, very few cases of “pure” 22q13 monosomy have been investigated up to now by detailed molecular studies. In order to characterise this syndrome better, facilitate the diagnosis, and provide targeted health care for affected individuals, we have studied 33 patients (32 new observations) with a pure 22q13 partial monosomy, using molecular and cytogenetic methods. ### Subjects Our study involved 33 patients with a “pure” partial 22q13 monosomy, with exclusion of all rearrangements involving loss or gain of euchromatic material from any other …
[Dynamic CT angiography in evaluation of collateral flow and outcome of acute ischemic stroke patients after intravenous thrombolysis].

OBJECTIVE To evaluate the collateral flow of patients with acute ischemic stroke by dynamic CT angiography (CTA) and to analyze the relationship between collateral flow and outcome after intravenous thrombolysis. METHODS We retrospectively analyzed CT perfusion (CTP) imaging of 22 acute ischemic stroke patients with middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion undergoing intravenous thrombolysis, and reconstructed the images for dynamic CTA in the Second Affiliated Hospital, Zhejiang University School of Medicine from June 2009 to October 2013. The total extent and flow speed of collateral flow based on dynamic CTA images of these patients were evaluated. The scores of National Institute of Health stroke scale (NIHSS) in different collateral flows were compared with repeated measuring. The nonparametric Spearman's rank correlation was used to assess the relationship between collateral flow and modified Rankin scale (mRS) at 3 months after thrombolytic therapy. RESULTS Compared with the poor collateral flow group, patients with good collateral flow had lower NIHSS at 1 month after thrombolysis (4.7±5.0 vs 25.1±15.1, P=0.001) and higher reperfusion percentage (69%±32% vs 23%±54%, P=0.044). The total condition score of collateral flow was positively correlated with mRS at 3 months after treatment (r=0.450, P=0.001). CONCLUSION Acute ischemic stroke patients with good collateral flow after intravenous thrombolysis have a better outcome. The dynamic CTA can be used to evaluate the collateral flow and to predict clinical outcomes in patients with acute ischemic stroke after thrombolysis therapy.