Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypofibrinogenemia Complicating Pregnancy - Case Report and Review of Literature

Congenital fibrinogen disorder may be either afibrinogenemia / hypofibrinogenemia / dysfibrinogenemia. Afibrinogenemia may present at birth as bleeding from umbilical cord. Patients with hypofibrinogenemia may present only during surgical intervention or during pregnancy. Pregnancy with this condition is associated with a very high incidence of abortion & abruption. Fibrinogen replacement can be done using either cryoprecipitate or fibrinogen concentrate. Successful pregnancies have been reported using cryoprecipitate & fibrinogen concentrate (FC). We report a woman with 6 abortions previously who was treated with fibrinogen replacement therapy & delivered a live child.
Stochastic parametrization and model uncertainty

Stochastic parametrization provides a methodology for representing model uncertainty in ensemble forecasts, and also has the capability of reducing systematic error through the concept of nonlinear noise-induced rectification. The stochastically perturbed parametrization tendencies scheme and the stochastic backscatter scheme are described and their impact on medium-range forecast skill is discussed. The impact of these schemes on ensemble data assimilation and in seasonal forecasting is also considered. In all cases, the results are positive. Validation of the form of these stochastic parametrizations can be found by coarse-grain budgets of high resolution (e.g. cloud-resolving) models; some results are shown. Stochastic parametrization has been pioneered at ECMWF over the last decade, and now most operational centres use stochastic parametrization in their operational ensemble prediction systems these are briefly discussed. The seamless prediction paradigm implies that serious consideration should now be given to the use of stochastic parametrization in next generation Earth System Models.
Aseptic Processing Of Liquid/particulate Foods

A generalized analytical solution to the set of coupled energy balance equations governing heat transfer in a system comprised of uniform radius spherical particles, with nonuniform initial temperature, heated in a well mixed liquid with time varying temperature, is initially derived. Based on this solution, analytical equations describing the temperature evolution for both fluid and particles, during processing of liquid/particulate food systems in a typical aseptic processing line, consisting of a heating, a holding, and a cooling section, are explicitly given. Sample calculations, illustrating the effect of the convective heat transfer coefficient at the particle surface, as well as the overall heat transfer coefficient between the liquid and its surroundings, are included.
Statistically significant hematopoietic effects of low blood lead levels.

Blood lead (Pb-b) concentrations, hematocrit (Ht), and hemoglobin (Hb) were determined in three groups of men working in different parts of a cable-producing factory. All three parameters examined, i.e., Pb-b, Ht, and Hb, in the above groups were found to be within "normal" limits. However, within each group of men studied, there was a statistically significant negative correlation between Pb-b concentrations and Ht and Hb values. This finding indicates that any increase in Pb-b concentration, even within the "normal" values, may result in a decrease of hematocrit and hemoglobin values of the same subjects.
Role of Lens Extraction in Primary Angle Closure Disease

An eye with angle closure glaucoma is anatomically characterized by a short axial length, a shallow anterior chamber, a thickened lens that is situated relatively anteriorly and a small corneal diameter. These conditions may lead to the development of relative pupillary block. Pupillary block is classically managed with a peripheral iridectomy which provides a route for the aqueous to drain. But in cases of an anteriorly placed thickened lens, appositional closure may persist even after a peripheral iridectomy has been done. In such cases lens extraction has been proved to have a significant role. This review aims to explore the available evidence about lens extraction in primary angle closure patients.
Specific arrests of spermatogenesis in genetically modified and mutant mice.

In naturally occurring mutant mice but also in mice genetically modified for the study of other organs, relatively often a spermatogenic arrest is seen. In a number of cases the arrests appear to be very specific causing apoptosis of germ cells at a particular step in their development, while before this step cells progress normally. These steps include: proliferation/migration of primordial germ cells, the production of differentiating spermatogonia by gonocytes, the regulation of stem cell renewal/differentiation, the differentiation of A(al) into A1 spermatogonia, proliferation of A1-A4 spermatogonia, germ cell density regulation, start of meiosis, epithelial stage IV checkpoint of pachytene spermatocytes, the first meiotic division, the formation of the acrosomic vesicle in spermatids and several other steps in spermatid development. In addition, there are many mice that have not been studied in enough detail for a proper categorization. In this review an overview is given of the various mutations and genetically modified mice showing a direct effect on specific spermatogenic cell types. In addition, the relevance of these models to our understanding of the spermatogenic process is discussed.
Causal observability of descriptor systems

Observability analysis for descriptor systems by using a matrix pencil approach is presented. Systems under consideration are the most general class of linear continuous descriptor systems. A few practically relevant notions of observability, particularly the causal observability which corresponds to the existence of a Luenberger observer and the corresponding necessary and sufficient test conditions, are provided. The interpretation of various observabilities in terms of matrix pencils offers insights into the physical meaning of these concepts.
Dental Inlay and Onlay Construction by Iterative Laplacian Surface Editing

We propose a new method for automatic construction of inlays and onlays. Mesh models from a small tooth library are adapted to the remaining healthy surface of the patient's tooth. In the area above the cavity, the general morphology of the model tooth (fissures, cusp tips, etc) is preserved, but precisely adjusted to the intra‐oral situation. Our approach uses iterative Laplacian Surface Editing to deform the model tooth. This allows the automatic generation of highly individual, functional and anatomically correct inlays/onlays, without having to resort to a large library of different tooth shapes.
Hemodynamic improvement following levosimendan treatment in patients with acute myocardial infarction and cardiogenic shock *

Objectives: Levosimendan, a novel inodilator, has been shown to improve hemodynamic function in patients with acute exacerbation of congestive heart failure. We wanted to determine the hemodynamic effects of levosimendan following ineffective conventional therapy (with catecholamines) in patients with cardiogenic shock following myocardial infarction. Design: Observational hemodynamic study. Setting: Tertiary care center university hospital. Patients: Fifty‐six patients with cardiogenic shock secondary to myocardial infarction were treated with percutaneous revascularization (intra‐aortic balloon pump where appropriate) and commenced on conventional inotropic therapy. Interventions: Patients with persisting cardiogenic shock 24 hrs after revascularization were additionally treated with levosimendan (rapid bolus of 12 &mgr;g/kg for 10 mins, then 0.05–0.2 &mgr;g/kg/min for 24 hrs) (n = 25). Measurements and Main Results: With conventional catecholamine therapy (norepinephrine and dobutamine), we observed only marginal improvement in mean arterial pressure or cardiac index. In contrast, the addition of levosimendan produced a significant increase in cardiac index (2.1 ± 0.56 to 3.0 ± 1.11 L/min/m2, p < .01) and cardiac power index (0.32 ± 0.08 to 0.44 ± 0.18 W, p < .01), whereas systemic vascular resistance decreased significantly (1208 ± 333 to 858 ± 299 dyne·sec·cm‐5, p < .01). There was no significant change in blood pressure during levosimendan treatment. Hemodynamic improvement was sustained after levosimendan infusion was stopped. Conclusions: Levosimendan infusion in cardiogenic shock following acute myocardial infarction improved cardiovascular hemodynamics without leading to hypotension.
Synergistic Activity of R207910 Combined with Pyrazinamide against Murine Tuberculosis

ABSTRACT In previous studies, the diarylquinoline R207910 (also known as TMC207) was demonstrated to have high bactericidal activity when combined with first- or second-line antituberculous drugs. Here we extend the evaluation of R207910 in the curative model of murine tuberculosis by assessing the activities of one-, two-, and three-drug combinations containing R207910 and isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), or moxifloxacin (MXF) in the setting of a high initial bacillary load (7.2 log10 CFU). Two months of treatment with the combinations R207910-PZA, R207910-PZA-INH, R207910-PZA-RIF, or R207910-PZA-MXF resulted in culture-negative lung homogenates in 70 to 100% of the mice, while mice treated with INH-RIF-PZA (the reference regimen) or RIF-MXF-PZA remained culture positive. Combinations including R207910 but not PZA (e.g., R207910-INH-RIF and R207910-MXF-RIF) were less active than R207910-PZA-containing regimens administered either alone or with the addition of INH, RIF, or MXF. These results reveal a synergistic interaction between R207910 and PZA. Three-drug combinations containing these two drugs and INH, RIF, or MXF have the potential to significantly shorten the treatment duration in patients, provided that these results can be confirmed in long-term experiments including periods of relapse.
PERCEPCIONES DE LA ALTA GERENCIA Y MODELO DE GESTIÓN POR COMPETENCIAS EN EMPRESAS DE BOGOTÁ

Este articulo caracteriza las percepciones y el modelo de gestion por competencias desde la Alta Gerencia en empresas de Bogota. El trabajo recoge dos experiencias desarrolladas en el marco de la Especializacion de Gerencia en Recursos Humanos de la Fundacion Universitaria Konrad Lorenz, cuyos hallazgos se analizan en este documento. La metodologia se centra en el analisis de casos, teniendo como tecnicas para recoleccion de informacion la revision documental, un grupo focal y entrevistas en profundidad con los Gerentes de recursos humanos en 7 empresas de Bogota. Los resultados revelan que el sistema de Gestion por competencias en estas empresas consultadas ha cobrado gran importancia en la estrategia de las organizaciones durante las ultimas decadas y que en la practica se utilizan diferentes estrategias para su fomento, sin embargo, aun se evidencian dificultades y falta de claridad en la implementacion del modelo de gestion por competencias en la mayoria de casos analizados.
Percutaneous Modalities for Atrial Fibrillation Ablation

Pulmonary vein isolation (PVI) is now accepted as a cornerstone modality for the treatment of paroxysmal atrial fibrillation (PAF) ablation (1). The technique has been started with focal pulmonary vein (PV) ablation of AF triggers or ostial isolation of the PVs (2-5). Nowadays, wide circumferential ablation of the PV antrum is the preferred approach (6). The potential role of different non-PV targets for the treatment of PAF (either alone or as an adjunct to PVI) has been inconclusive, yet.
UV‐induced activation of AP‐1 involves obligatory extranuclear steps including Raf‐1 kinase.

Irradiation of cells with ultraviolet light (UV) leads to modifications of c‐Jun resembling those elicited by phorbol esters or oncogenes, and to enhanced transcription of AP‐1‐dependent genes. The UV‐induced signal also triggers activation of Raf‐1 and MAP‐2 kinases. A dominant‐negative Raf‐1 kinase mutant strongly interferes with both phorbol ester and UV‐induced AP‐1 activation, indicating obligatory involvement of identical components in cytoplasmic signal transduction. Thus, from a presumably nuclear site of energy absorption, a signal needs to be transmitted to the cytoplasm in order to achieve activation of a nuclear transcription factor. Further, signals elicited from different primary sites merge prior to or at the level of activation of Raf‐1 kinase.
Modeling industrial centrifugation of mammalian cell culture using a capillary based scale‐down system

Continuous‐flow centrifugation is widely utilized as the primary clarification step in the recovery of biopharmaceuticals from cell culture. However, it is a challenging operation to develop and characterize due to the lack of easy to use, small‐scale, systems that can be used to model industrial processes. As a result, pilot‐scale continuous centrifugation is typically employed to model large‐scale systems requiring a significant amount of resources. In an effort to reduce resource requirements and create a system which is easy to construct and utilize, a capillary shear device, capable of producing energy dissipation rates equivalent to those present in the feed zones of industrial disk stack centrifuges, was developed and evaluated. When coupled to a bench‐top, batch centrifuge, the capillary device reduced centrate turbidity prediction error from 37% to 4% compared to using a bench‐top centrifuge alone. Laboratory‐scale parameters that are analogous to those routinely varied during industrial‐scale continuous centrifugation were identified and evaluated for their utility in emulating disk stack centrifuge performance. The resulting relationships enable bench‐scale process modeling of continuous disk stack centrifuges using an easily constructed, scalable, capillary shear device coupled to a typical bench‐top centrifuge. Bioeng. 2011; 108:989–998. © 2010 Wiley Periodicals, Inc.
Paradox lost: Explaining the hispanic adult mortality advantage

We tested three competing hypotheses regarding the adult “Hispanic mortality paradox”: data artifact, migration, and cultural or social buffering effects. On the basis of a series of parametric hazard models estimated on nine years of mortality follow-up data, our results suggest that the “Hispanic” mortality advantage is a feature found only among foreign-born Mexicans and foreign born Hispanics other than Cubans or Puerto Ricans. Our analysis suggests that the foreign-born Mexican advantage can be attributed to return migration, or the “salmon-bias” effect. However, we were unable to account for the mortality advantage observed among other foreign-born Hispanics.
A maxillofacial tumour after liver transplantation

A 64-year-old man with a Child-Pugh A cirrhosis because of non-alcoholic steato-hepatitis was referred to our unit in 2005. A 1 cm hepatic mass was treated initially by radiofrequency ablation and by transcatheter arterial chemoembolization. On magnetic resonance imaging (June 2009), the tumour measured 65 9 50 mm with peripheral enhancement, hyperintensity on arterial phase (arrowheads) and a retraction of the adjacent liver capsula (arrow, Fig.1A), but no contrast washout on venous phase. A liver transplantation was performed in August 2010 and the explant revealed tubular adenocarcinoma compatible with a cholangiocarcinoma. In January 2011, the patient presented a swollen cheek (Fig.1B) because of a 23 9 29 mm tissular osteolytic mass of the left zygomatic arch and maxillary sinus anterior wall [maxillofacial CT without (Fig.1C) and with iodinated contrast (Fig.1D)]. We note the invasion of the adjacent soft tissues and a left maxillary sinusitis (star, Fig.1D). Histologically, the resected tumour was similar to that of the primary liver lesion. Our patient received local radiotherapy and five chemotherapy sessions. On May 2011, he died of a haemorrhagic stroke. We report here the second case of maxillofacial cholangiocarcinoma metastasis (1). Hepatologists should apply guidelines specifying that if the (A) (C)
Differential Phase-Shift-Keying Technique-Based Brillouin Echo-Distributed Sensing

In this letter, we experimentally demonstrate Brillouin echoes-based distributed optical fiber sensing with centimeter spatial resolution. It is based on a differential phase-shift-keying technique using a single Mach-Zehnder modulator to generate a pump pulse and a π-phase-shifted pulse with an easy and accurate adjustment of delay. The results are compared to those obtained in standard Brillouin echo-distributed sensing system with two optical modulators and clearly show a resolution of 5 cm in a spliced segment between two fibers by applying a π -phase-shifted pulse of 500 ps.
Agent based decentralized three-phase load flow computation of unbalanced distribution system

Incessant network expansion, DG integration, system unbalances, growing solution complexity and increased communication saturation in distribution system have instigated the requirement of new solution methodologies for smooth and swift system analysis and operations. Hence, this paper proposes a fundamental framework on decentralized three phase load flow analysis of a distribution network. This framework is designed using Multi-Agent technology, wherein a single Bus Agent (BA) is designed. The objective of this BA is to compute the three phase voltages of its representative bus by utilizing the locally available information and inter agent communication. BA incorporate forward and backward sweep behaviors to compute bus voltages. The proposed framework is implemented in JaVA with JADE package and simulated on IEEE 34 node test feeder system with unbalanced loading conditions. The results showcase the validity and feasibility of the proposed decentralized system analysis.
An Implicit Data Structure for the Dictionary Problem that Runs in Polylog Time

We introduce a data structure that requires only one pointer for every k data values and permits the operations search, insert and delete to be performed in 0 (k log n) time. This structure is used to develop another that requires no pointers and supports insert, delete and search in 0 (log2 n) time.
A Pilot Study of Netilmicin Pharmacokinetics During Continuous Venovenous Hemodiafiltration

N a semisynthetic aminoglycoside, is administered to patients in the intensive care unit (ICU), usually in combination with β-lactam antibiotics to treat severe infections caused by gram-negative bacteria. It is considered to be the least otoand nephrotoxic aminoglycoside, and it is for this reason that it is widely used in this clinical setting. Acute renal failure is a serious and common complication in critically ill patients. Continuous venovenous hemodiafiltration (CVVHD) has been introduced in intensive care units for patients in whom intermittent hemodialysis fails to control hypervolemia or uremia and for those who do not tolerate intermittent hemodialysis and in whom peritoneal dialysis is not possible. To date, the pharmacokinetics of aminoglycosides such as isepamicin, gentamicin, and amikacin during CVVHD have been studied. Netilmicin pharmacokinetics during CVVHD have not yet been characterized. The purpose of this pilot study was to describe the pharmacokinetics of netilmicin during CVVHD, following the administration of the standard dosage regimen used in the ICU of the Konstantinopoulio Hospital, Greece. MATERIALS AND METHODS
Analysis of Complete Responders after Initial Treatment with Chemotherapy in Head and Neck Cancer

We treated 60 patients with cisplatin-based combination chemotherapy before definitive surgery and/or radiation. All had squamous cell tumors of the head and neck, stages II to IV, M0. Twelve patients (20%) achieved a complete remission after chemotherapy. Eight of these patients showed no histologic evidence of residual disease after biopsy or surgery. Definitive local therapy with surgery and/or radiation was carried out on almost all patients regardless of the extent of the response to preceding chemotherapy. Chemotherapy-induced complete responders have had an improved survival rate in comparison with patients achieving a partial response or less. The extent of primary tumor correlates inversely with a complete response to chemotherapy.
Saperconazole therapy of murine disseminated candidiasis: efficacy and interactions with amphotericin B

The efficacy of a new triazole antifungal agent, saperconazole, in a murine model of disseminated candidiasis was studied. Mice were intravenously infected with Candida albicans blastoconidia and treated for 14 days with oral saperconazole, intraperitoneal amphotericin B, or a combination of these. Amphotericin B alone was the most efficacious in prolonging survival and in decreasing renal colony counts, usually with complete sterilization of the kidneys by the end of the treatment course. Saperconazole improved survival rates and effected a decrease in renal colony counts, but kidneys were not microbiologically sterilized. Combination therapy with saperconazole and amphotericin B did not result in a decrease in the efficacy of amphotericin B by either end point (survival or renal colony counts). High-pressure liquid chromatographic analysis of saperconazole concentrations in serum indicated low levels of absorption of the drug. We conclude that saperconazole is effective in the treatment of murine invasive candidiasis and that the theoretical concern about adverse interactions between the two drugs does not apply to the dosages studied in these experiments.
DISRUPTIVE SELECTION ON HABITAT PREFERENCE AND THE EVOLUTION OF REPRODUCTIVE ISOLATION: A SIMULATION STUDY

There has been a wide diversity of theoretical work on the genetic mechanisms that promote speciation under sympatric (non-allopatric) conditions (see Thoday and Gibson, 1970; Bush, 1975; Endler, 1977; White, 1978; Futuyma and Mayer, 1980; Templeton, 1981 for review). The conclusion from this work is that sympatric speciation is genetically possible but it is not clear whether or not it has played a major role in the generation of species under natural conditions. Assessing the evolutionary importance of sympatric speciation awaits the identification of those environmental circumstances that are most likely to promote the process. Here I suggest that environmental conditions which produce disruptive selection on habitat preference represent a special case in which sympatric speciation is particularly likely to occur. By habitat preference I mean any tendency of an organism to become non-randomly associated with a particular spatial and/ or temporal part of an environment.
Time-frequency transform used in radar Doppler tomography

The paper focuses on the radar imaging for a rotating object using tomographic method. The simplified mathematical model of radar returns from one rotating scatterer is used for generating of radar projections required in tomographic imaging. These projections are strictly connected with micro-Doppler phenomena and give the frequency characteristics over time. Doppler radar tomography imaging is performed in the narrow-band radar. The modulus of the Short Time Fourier Transform of radar returns is proposed as radar projections. It is experimentally shown on the simulated data, that applying the reassigned spectrogram nearly smear-free projections could be obtained. So the reassigned Short Time Fourier Transform looks promising as projections. Next the back projection algorithm is applied to reconstruct the image in order to get the spatial location of the rotating point using simulated projections. High-resolution radar image strongly depends on smear-free projections so methods for improving the projections are intensively explored.