Miracle-dz/UniFAR-FTUs huggingface dataset:
Alternative splicing dysregulation secondary to skeletal muscle regeneration

Dysregulation of alternative splicing has become a molecular hallmark of myotonic dystrophy type 1 (DM1), in which neonatal splice variants are expressed in adult skeletal muscle. Splicing dysregulation is induced by RNA containing expanded CUG repeats expressed from the expanded mutant allele by sequestration of muscleblindlike 1 (MBNL1) protein within nuclear RNA foci and increased CUGBP, ELAV‐like family member 1 (CELF1) protein levels. Dysregulated splicing has also been identified in other neuromuscular disorders, suggesting either that diseases with different molecular causes share a common pathogenic mechanism or that dysregulated splicing can also be a common secondary consequence of muscle degeneration and regeneration.
The Effect of Capital Structure on Firm's Profitability: A Case of Listed Malaysian Industrial Firms

This paper attempts to examine the influence of capital structure, particularly in the presence of market imperfections on firm's profitability. The effect of corporate taxes, interest expense, debt level and equity size is analyzed using OLS estimates and correlation analysis. The research model justifies that capital structure changes in response to market imperfections which subsequently affect profitability. This findings empirically implies that: (a) higher debt level result in a lower profitability; (b) higher profitability associates positively with taxation expense but negatively with interest expense.
A compact size 12-Port Combiner/Splitter

A compact size 12-Port Power Combiner/Splitter is designed and fabricated for 2.45 GHz operation. The combiner provides measured isolation between its ports of at least 22.5 dB and an amplitude imbalance of less than 1 dB. The combiner is fabricated on an FR-4 substrate with 0.8 mm thickness. The total size of the board is 78 × 61 × 0.8 mm3. The phase imbalance due to the internal IC phase imbalance was minimized by more than 30% via careful PCB design and phase compensation.
Learning System-assigned Passwords: A Preliminary Study on the People with Learning Disabilities

With an increase in cyber attacks, including online pass-word guessing attacks, system-assigned password schemes are studied as alternatives to traditional user-chosen textual passwords. While people with learning disabilities face diﬃculty in memorizing new information, it is not clear yet if system-assigned passwords would be usable for them. We begin to address this gap with this preliminary study, where we leveraged a recently-proposed graphical authentication scheme that oﬀers multiple cues (visual, verbal, spatial, audio) to memorize system-assigned random passwords. In our single-session study with 14 participants having diﬀer-ent types of learning disabilities, all of them could eﬀectively learn system-assigned passwords, and were able to successfully log in using that authentication secret within just one attempt. Based on our ﬁndings, we outline the directions for future research in evaluating the authentication performance of people with learning disabilities.
Financial Sector Assessment Program: IEG Review of the Joint World Bank and IMF Initiative

The Financial Sector Assessment Program (FSAP) is a major initiative, undertaken jointly by the World Bank and the IMF, in response to the financial crises of the late 1990s. The ultimate objectives of the program are (i) the identification and resolution of financial sector vulnerabilities and their macroeconomic stability implications; and (ii) fostering financial sector development and its contribution to economic growth. In addition, the FSAP was expected to help the Bank, Fund, and other institutions design appropriate assistance to address issues identified by the FSAP.
A Partnership Approach to Work Placement in Higher Education

Abstract There is a perceived gap between traditional university education and a readiness to enter the workforce which is often addressed by the inclusion of a work-based learning experience within the undergraduate education process. The intention of the curriculum designers is that the work placement experience will provide learners with an opportunity to develop their employability skills and to apply the knowledge that they have gained within a practice setting. This practice-focused paper summarises the work conducted under the REAP (Roadmap for Employment-Academic Partnerships) project, illustrating existing practice in work placement and gathering input and experiences from higher education staff and employers. The aim of the work was to explore practice in work placement in undergraduate programmes in Ireland and to develop an outline guide to support good practice. The importance of the work placement interaction in contributing to the development of a broader more sustainable relationship is considered briefly. REAP is a collaborative project funded by the HEA (Higher Education Authority), involving a number of Higher Education institutions in Ireland aimed at developing systems and structures which support good practice in engagement interactions between higher education and enterprise. The research into work placement practice was undertaken in a number of ways. Higher education staff were invited to partake in seminars and workshops. The employers participated mainly by way of a survey with some in-depth interviews providing deeper insights into work placement and other potential interactions. The research allowed a generalised view of the work placement process to be developed and a series of stages with associated practice recommendations were identified. The importance of engagement with the employer before, during and after the placement process was highlighted and the role of the employer as a partner in the learning development underlined.
Let Greece take a holiday from the eurozone

Loan guarantees or temporary credits from Germany and France may allow Greece to avoid a refunding crisis later this spring. But temporary financial patches will not deal with the real problem: Greece's budget deficit of 13 per cent of gross domestic product. To prevent an exploding ratio of government debt to GDP, Greece needs to cut future annual spending and increase its future taxes in a com-bination equivalent to at least 10 per cent of GDP.
Skeletal muscle sodium channelopathies.

PURPOSE OF REVIEW This is an update on skeletal muscle sodium channelopathies since knowledge in the field have dramatically increased in the past years. RECENT FINDING The relationship between two phenotypes and SCN4A has been confirmed with additional cases that remain extremely rare: severe neonatal episodic laryngospasm mimicking encephalopathy, which should be actively searched for since patients respond well to sodium channel blockers; congenital myasthenic syndromes, which have the particularity to be the first recessive Nav1.4 channelopathy. Deep DNA sequencing suggests the contribution of other ion channels in the clinical expressivity of sodium channelopathies, which may be one of the factors modulating the latter. The increased knowledge of channel molecular structure, the quantity of sodium channel blockers, and the availability of preclinical models would permit a most personalized choice of medication for patients suffering from these debilitating neuromuscular diseases. SUMMARY Advances in the understanding of the molecular structure of voltage-gated sodium channels, as well as availability of preclinical models, would lead to improved medical care of patients suffering from skeletal muscle, as well as other sodium channelopathies.
Standardized terminology for oxide charges associated with thermally oxidized silicon

Standarized terminology for oxide charges associated with the thermally oxidized silicon system is presented. This terminology is recommended by a committee established by the Electronics Division of the Electrochemical Society and the IEEE Semiconductor Interface Specialists Conference. All engineers and scientists concerned with oxide charges in silicon semiconductor applications are urged to adopt this terminology.
Comparison of the transfusion effects of fresh and cryopreserved apheresis platelets

In this study, the clinical transfusion effects of fresh and cryopreserved apheresis leukocyte-reduced Platelets (PLTs) were examined. In total, 102 patients admitted to our hospital between August 2012 and August 2013 were enrolled, including 50 non-hematonosis patients and 52 hematonosis patients. Among them, 45 received fresh apheresis PLTs and 57 received cryopreserved PLTs. Patient blood PLT counts before and after transfusion were measured and the Percentage of Platelet Recovery (PPR) was compared among groups. The PPR for the cryopreserved PLT group was 25.03 ± 52.06%, which was significantly lower than that of the fresh PLT group (47.06 ± 42.94%, t=2.29, P<0.05). The PPR of the non-hematonosis group (51.01 ± 65.10%) was significantly lower than that of the hematonosis group (21.40 ± 24.23%; t’=2.92, P<0.05). Fresh apheresis leukocyte-reduced PLTs were safer and more effective than cryopreserved apheresis leukocyte-reduced PLTs. Transfusion was more effective in nonhematonosis patients than in hematonosis patients.
A Scheduling Method on Selective Contents Broadcasting with Node Relay Based Webcast Considering Available Bandwidth

Due to the recent popularization of digital broadcasting systems, selective contents broadcasting depending on viewers' preference have attracted great attention. For example, a user selects his answer and watches the video content for the answer in a quiz program. The conventional methods reduce the waiting time by producing an effective broadcast schedule. Although the server can deliver programs that meet users' preferences, clients have to wait until their selected contents are delivered. In this paper, we propose a method to reduce the waiting time on selective contents delivery with node relay based webcast that relay data among nodes. Our proposed method reduces the waiting time by scheduling contents considering available bandwidth of each nodes.
Motivation, Coordination and Cognition in Cooperatives

textabstractA cooperative is a firm collectively owned by many independent input suppliers or buyers. This dissertation examines the nature of a cooperative and its efficiency compared with other governance structures from the perspectives of motivation, coordination and cognition. We find that the lack of public listing in cooperatives may result in the cooperative being the unique efficient governance structure under either one of two conditions: 1) additional sources of information like accounting information and subjective performance evaluations are available; 2) the upstream marginal product multiplied with a function increasing in the strength of the chain complementarities is higher than the downstream marginal product. A cooperative as a coordination device is always efficient due to its prevention of double mark-up. The influence of governance structures (market, cooperative, forward integration, and backward integration) on the information partitions of boundedly rational agents is also investigated. We show that each governance structure can be efficient, depending on the probabilities of the various states and the size of the potential benefit and loss. A cooperative enterprise’s conservativeness to change is explained. In sum, the main objective of the dissertation is to deepen the current understanding of the cooperative as one governance structure out of many. It is compared with other governance structures from various perspectives. In doing so, I hope to ease the doubt of some researchers regarding the efficiency of the cooperative and to identify the conditions under which cooperatives are efficient.
Supply Chain Risk Management: Vulnerability and Resilience in Logistics

Chapter - 01: Working with risk Chapter - 02: Defining risk Chapter - 03: Supply chain management Chapter - 04: Trends affecting the supply chain Chapter - 05: Approaches to risk management Chapter - 06: Identifying risks Chapter - 07: Analysing risks Chapter - 08: Responding to risks Chapter - 09: A network view of risk Chapter - 10: Creating resilient supply chains Chapter - 11: Business continuity management Chapter - 12: Review
Expert financial planning : investment strategies from industry leaders

About the Contributors. Preface. TAKING CONTROL. Developing a Financial Plan (J. Meredith & R. Arffa). Achieving Financial Security (S. Arffa & R. Arffa). INVESTING-- GENERAL. Investment Vehicles: Description and Historic Performance (R. Arffa). Earning Interest on Cash (J. Mueller). STOCK SELECTION. Fundamental Stock Analysis (R. Arffa). Growth Investing (R. Driehaus). Value Investing: A Philosophy for Life (D. Winters). Other Stock Selection Strategies (R. Arffa). The Efficient Markets Hypothesis (J. Clarke, et al.). MUTUAL FUNDS. Stock Mutual Funds (R. Arffa). Index Funds and Managed Funds: Echoes of Archilochus (J. Bogle). Evaluating Mutual Fund Performance (E. Fama & W. Wellington). When to Sell Your Fund (R. Arffa). Guidance Gleaned from the Gurus (P. Tanous). International Investing (R. Arffa). Hedge Funds (L. Hennessee & C. Gradante). OTHER INVESTMENTS. Private Investment Management (L. Blonkvist). The Impact of Taxes and Other Costs on Total Returns (L. Swedroe). Debt in the U.S. Capital Markets (G. Guild). Real Estate Investment Trusts (R. Deckey). Venture Capital (D. Hillman). Asset Allocation (G. Curtis). FINANCIAL PLANNING. Retirement Planning (G. Weinstein & B. Newman). Estate Planning (H. Apolinsky). Insurance (P. Katt). Glossary. Index.
LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

BACKGROUND & AIMS One approach to the development of targeted cancer chemotherapy exploits increased uptake of the agent into neoplastic cells. In this scenario, higher concentrations of the agent in cancer cells are responsible for differential killing, whereas the low concentration in normal human cells decreases side effects. The aim of this study was to isolate an organic anion transporter that is weak in normal cells, but abundantly expressed in cancer cells, to deliver the anticancer drugs to the cells. METHODS A human liver complementary DNA (cDNA) library was screened with liver-specific transporter (LST)-1 cDNA as a probe. Northern blot analyses were performed using the isolated cDNA (termed LST-2). An LST-2-specific antibody was raised, and immunohistochemical analyses including immunoelectron microscopy were performed. Xenopus oocyte expression system was used for functional analysis. We also established a permanent cell line that consistently expresses LST-2 to examine the relationship between methotrexate uptake and sensitivity. RESULTS The isolated cDNA, LST-2, has 79.7% of overall homology with human LST-1. LST-2 exclusively expressed in the liver under normal conditions and its immunoreactivity was highest at the basolateral membrane of the hepatocytes around the central vein. Although its weak expression in the liver, LST-2 is abundantly expressed in the gastric, colon, and pancreatic cancers. On the other hand, the LST-1 was only detected in a hepatic cell line. LST-2 transports methotrexate in a saturable and dose-dependent manner. Furthermore, introduction of the LST-2 gene into mammalian cells potentiates sensitivity to methotrexate. CONCLUSIONS LST-2 is one of the prime candidate molecules for determining methotrexate sensitivity and may be a good target to deliver anticancer drugs to the gastrointestinal cancers.
A 6-way power combining amplifier based on traveling-wave waveguide

This paper presents a 6-way power combining amplifier based on a 3-way traveling-wave waveguide combiner and waveguide-microstrip double probes. According to the reactive measure results, the input and output return loss (RL) of the 6-way dividing/combining networks are more than 17 dB from ×3.5 GHz to ×5.5 GHz.The insert loss (IL) of the back-to-back is about 1.5 dB, the combining loss is about 0.65dB. The saturated power (Psat) of the power amplifier (PA) is more than 9 W, the combining efficiency is about 80%.
The effect of electro-acupuncture on pro-oxidant antioxidant balance values in overweight and obese subjects: a randomized controlled trial study

Abstract Objective To undertake a randomized controlled trial in 196 obese subjects to examine the effect of electro-acupuncture on serum pro-oxidant antioxidant balance (PAB) values. Methods Subjects received authentic acupuncture (cases) or sham acupuncture (controls) for 6 weeks in combination with a low-calorie diet. In the following 6 weeks, they received the low-calorie diet alone. Serum PAB was measured at baseline, and 6 and 12 weeks later. Results We found that serum PAB values decreased significantly in the group receiving the authentic acupuncture compared to the sham treatment (p<0.001) at week 6, and whilst serum PAB increased significantly (p<0.05) in the second phase of the study, a significant difference between two groups remained at 12 weeks (p<0.05). Conclusions Electro-acupuncture in combination with a low-calorie diet was more effective at reducing serum PAB values in obese subjects compared to diet alone. Further work is required to determine the mechanism by which electro-acupuncture has this effect.
Novel Compact Eye-Shaped UWB Antennas

This letter proposes a novel shrinking technology of ultrawideband (UWB) antennas among the conventional various ultrawideband antenna structures. An eye-shaped UWB antenna was designed to extend the lower frequency band under a limited antenna size. The operating band (1.2 ~ 4.5 GHz) can reach a fractional bandwidth of as high as 142%. The overall dimension, including the ground area, can be shrunk to 0. 027λ02. The group delay is nearly constant to ensure minimal distortion and dispersion. From the measurement, the antenna radiation pattern is close to omnidirectional and is suitable for general applications.
A new method for designing analytical non-diagonal PID controller for two-by-two processes with time delays

A new analytical non-diagonal PID controller design method is proposed for industrial and chemical two-by-two processes with time delays. By extending the concept of coupling matrix for uncertain multivariable delay-free processes to TITO processes with time delays, the relation between the non-diagonal and the diagonal elements of decoupling controller is determined and the controller is derived inversely from the proposed closed-loop transfer function. Pade approximation is then utilized to reproduce the decoupling controller in the form of a non-diagonal PID controller for implementation. Tuning rules for the proposed controller are developed based on system robust stability analysis. A simulation example is included to show the superiority of the proposed method
Corporate fraud and misconduct : investigative and regulatory priorities

This article investigates the profile of the companies that have been investigated for corporate fraud and misconduct. Our definition of fraud includes financial statement fraud, market misconduct fraud such as insider trading or false disclosures, and managerial fraud. The particular evidence presented relates to those instances of corporate fraud and misconduct investigated by the Australian corporate regulatory, Australian Securities and Investments Commission (ASIC), and relates to sanctions for fraud, misconduct or compliance breaches. Using data compiled from the public announcements in the ASIC reports over the period 2004-2008, we categorise the type of fraud and misconduct breaches ASIC chooses to report and investigate.
A three-phased approach for developing dynamic organisational fitness

In fast-changing business environments, organisations are often engaged in both adaptive (reactive) and inventive (shaping) change processes, and these require different types of organisational fitness capabilities. Research conducted in a wide range of industries reveals that many organisations are predominantly focused on past successes and internal difficulties, and do not possess the necessary dynamic fitness capabilities to adjust to rapidly changing business environments. This paper explores how organisations can develop dynamic fitness capabilities, and proposes a logical three-phased approach to develop Dynamic Organisational Fitness (DOF) capabilities on a continuous basis.
Fatty Acid Alterations in Liver Peroxisomes from n–3-Deficient Mice

A diet deficient in n–3 fatty acids dramatically reduces docosahexaenoic acid (4.8-fold) and 20:5n–3 content in murine total peroxisomal phospholipids, and conversely increases 22:5n–6 (17.1-fold) and also, to a lesser extent, 20:4n–6. This was also found in purified phosphatidylethanolamine and phosphatidylcholine. After changing the non-deficient diet (containing α-linolenic acid, ALA) to a deficient one (deficient in ALA), it took a very long time for docosahexaenoic acid concentration in peroxisomes to decline (>5 months). In contrast, after changing the deficient to a non-deficient diet, time to complete recovery was more rapid (3 weeks). Changes in 20:5n–3, 22:6n–3 and 20:4n–6 were generally stabilized within 2–4 weeks. Dietary n–3 fatty acids control the fatty acid composition of peroxisomal membranes, and thus possibly affect some of their functions.
Energy‐aware cross‐layer resource allocation in mobile cloud

This paper proposed an energy‐aware cross‐layer mobile cloud resource allocation approach. In this paper, a hybrid cloud architecture is adopted for provisioning mobile service to mobile device users, which include nearby local cloud and remote public cloud. The computation‐intensive tasks can be processed by the remote public cloud, while the delay‐sensitive computation can be processed by the nearby local cloud. On the basis of the system context and mobile user preferences, the energy‐aware cross‐layer mobile cloud resource allocation approach can optimize the consumption of cloud resource and system performance. The cooperation and collaboration among local cloud agent, public cloud supplier, and mobile cloud user are regulated through the economic approach. The energy‐aware cross‐layer mobile cloud resource allocation is performed on the local cloud level and the public cloud level, which comprehensively considers the benefits of all participants. The energy‐aware cross‐layer mobile cloud resource allocation algorithm is proposed, which is evaluated in the experiment environment, and comparison results and analysis are discussed.
A New Commissioning and Deployment Method for Wireless Sensor Networks

Sensor networks are deployed on various environments in order to collect sensing information in many cases. It is not easy to optimize program codes of all nodes due to the environmental variety of deployment of sensor networks. Therefore, commissioning procedure for each sensor node is required for optimized node programming. We suggest a new commissioning and deployment method for wireless sensor network. In this paper, we introduce our partial download procedure of node program for the efficient node commissioning. As a result, the update time of node program can be dramatically reduced by using a proposed method.
2 Preferred Answer Sets for Ordered Programs

We describe the design of the OLPS system, an implementation of the preferred answer set semantics for ordered logic programs. The basic algorithm we propose computes the extended answer sets of a simple program using an intuitive 9-valued lattice, called T9. During the computation, this lattice is employed to keep track of the status of the literals and the rules while evolving to a solution. It turns out that the basic algorithm needs little modification in order to be able to compute the preferred answer sets of an ordered logic program. We illustrate the system using an example from diagnostic reasoning and we present some preliminary benchmark results comparing OLPS with existing answer set solvers such as SMODELS and DLV.