Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence-based systematic review of cognitive rehabilitation, emotional, and family treatment studies for children with acquired brain injury literature: From 2006 to 2017

ABSTRACT This paper updates guidelines for effective treatments of children with specific types of acquired brain injury (ABI) published in 2007 with more recent evidence. A systematic search was conducted for articles published from 2006 to 2017. Full manuscripts describing treatments of children (post-birth to 18) with acquired brain injury were included if study was published in peer-reviewed journals and written in English. Two independent reviewers and a third, if conflicts existed, evaluated the methodological quality of studies with an Individual Study Review Form and a Joanna Briggs Institute (JBI) Critical Appraisal Checklist. Strength of study characteristics was used in development of practice guidelines. Fifty-six peer-reviewed articles, including 27 Class I studies, were included in the final analysis. Established guidelines for writing practice recommendations were used and 22 practice recommendations were written with details of potential treatment limitations. There was strong evidence for family/caregiver-focused interventions, as well as direct interventions to improve attention, memory, executive functioning, and emotional/behavioural functioning. A majority of the practice standards and guidelines provided evidence for the use of technology in delivery of interventions, representing an important trend in the field.
Bandwidth Access And Interference Mitigation Techniques For Femtocells

Abstract- With the continuously increasing the need of mobile users there is need for the cellular network operators to upgrade the networks by which they can meet the requirements of current users. Network operators cannot do this only by availing new spectrum but they have to improve their network architecture as well. In 4G networks the new standards LTE-Advanced are used to improve the network architecture. In LTE-Advanced the Femtocells are used to meet the requirements of indoor users. We cannot investigate the problem of interference in Femtocells using traditional cellular methods. We use the bandwidth flexibility, provided by OFDMA, to efficiently use the spectrum by Femtocells. In this paper we discuss the various methods by which the femtocells can access the bandwidth. Keywords- OFDMA, LTE, Femtocells, 4G, Two-tier Architecture.
PARTICIPATION IN PHYSICAL ACTIVITIES AND EVERYDAY LIFE OF PEOPLE WITH DISABILITIES

The purpose of this study was to investigate the correlation between participating in physical activity on a regular basis and civic activities for people with disabilities. Data were collected using telephone interviews with 1,321 people, who reported having some impairment related to legs, arms, hands, vision, behaviour or intellect. The sample was randomly selected by The Danish National Centre for Social Research, which also conducted the interviews. The data material is representative of all persons in Denmark aged 16 - 64 years according to gender, age, income, employment and education, and analyses were conducted using STATA 11.2. The study observed a significant correlation between a participation in physical activities and employment, educational status, volunteerism, leisure time schooling and membership in a disability organization. Among the participants in physical activities, women were in the majority, and a correspondence analysis revealed complex relations between participation in physical activities and civic activities, which might be elaborated on through further research. The results of this study give supporting arguments and provide the impetus for including physical activity and sport as a consistent means in the rehabilitation process, while improving the opportunities for people with disabilities to help gain access to appropriate physical activities in their local community.
Draft Genome Sequence of a Red Basidiomycete Yeast, Symmetrospora coprosmae Strain UCD350, Isolated from Soil in Ireland

Symmetrospora coprosmae is a red yeast from the subphylum Pucciniomycotina in the phylum Basidiomycota. Here, we present the first genome sequence of S. coprosmae strain UCD350, from an isolate collected from soil in Ireland. The genome size is 20.2 Mb. ABSTRACT Symmetrospora coprosmae is a red yeast from the subphylum Pucciniomycotina in the phylum Basidiomycota. Here, we present the first genome sequence of S. coprosmae strain UCD350, from an isolate collected from soil in Ireland. The genome size is 20.2 Mb.
SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment

Synthetic lethality exploits the phenomenon that a mutation in a cancer gene is often associated with new vulnerability which can be uniquely targeted therapeutically, leading to a significant increase in favorable outcome. DNA damage and survival pathways are among the most commonly mutated networks in human cancers. Recent data suggest that synthetic lethal interactions between a tumor defect and a DNA repair pathway can be used to preferentially kill tumor cells. We recently published a method, DiscoverSL, using multi-omic cancer data, that can predict synthetic lethal interactions of potential clinical relevance. Here, we apply the generality of our models in a comprehensive web tool called Synthetic Lethality Bio Discovery Portal (SL-BioDP) and extend the cancer types to 18 cancer genome atlas cohorts. SL-BioDP enables a data-driven computational approach to predict synthetic lethal interactions from hallmark cancer pathways by mining cancer’s genomic and chemical interactions. Our tool provides queries and visualizations for exploring potentially targetable synthetic lethal interactions, shows Kaplan–Meier plots of clinical relevance, and provides in silico validation using short hairpin RNA (shRNA) and drug efficacy data. Our method would thus shed light on mechanisms of synthetic lethal interactions and lead to the discovery of novel anticancer drugs.
Growth and Foreign Debt: The Ugandan Experience

This paper analyses Uganda's external debt problem. Like many other countries in the sub-Saharan Africa, Uganda is a severely indebted low-income country. Uganda's total debt stock at end June 1993 was estimated at US$2.64 billion, with a debt service ratio of nearly 80%. A look at Uganda's debt profile since the 1970s reveals a composition of debt mainly from multilateral creditors. The study particularly links debt to economic growth. A major observation is the acute debt servicing obligation of the country, and the fact that a large proportion of Uganda's debt is not eligible for rescheduling. Debt payments have been a fundamental cause of low economic growth. Of great concern is whether the economy can sustain its current growth rate of 5% per annum and at the same time maintain adequate domestic investment, given the heavy reliance on foreign import capital flows. Debt relief is not enough; continued government commitment to structural reforms and sound debt management are essential. The need to continue the ongoing restructuring of the economy and promote further growth is apparent. But how sustainable and possible is this challenging path without accumulating more debt?
Evaluation of Visfatin in Patients with Obesity, Metabolic Syndrome, Insulin Resistance and Impaired Glucose Tolerance; Case-Control Study

Introduction: Visfatin is a novel adipokine originally described to be produced predominantly by visceral fat tissue. The aim of the study was aimed to investigate visfatin level in non-diabetic obese patients with or without MetS and prediabetes. Methods: The cross-sectional study enrolled 169 subjects. Anthropometric measures and metabolic parameters were obtained. Exclusion criteria were pregnancy, smoking, any of the chronic disease. Blood sample was collected overnight fasting and centrifuged, and stored at refrigerator at -70o degree until to be assayed. Visfatin was assayed with ELISA method. Results: The study enrolled 169 subjects aged 36.9 ± 8.5 years (control group = 52 and obese group: 117; and Male: 28 and Female: 141). Among obese subjects, the frequency of MetS, and PreDM was respectively 35.1% (n = 41) and 70.1% (n = 82). Mean concentration of serum visfatin among subjects with obesity was significantly higher those with normal weight subjects (10.39 ± 2.30 versus 6.9 ± 2.2 ng/mL; p < 0.001). The subjects with IR+ (10.58 ± 2.48 ng/mL ) had significantly higher visfatin concentration than those with IR- (10.58 ± 2.48 ng/mL and 8.47 ± 2.65 ng/mL) (p < 0.001, respectively). Visfatin positively correlated with BMI (r = +0.627 and p < 0.001), WHR (r = +0.203 and p = 0.023), HOMA-IR (r = +0.329 and p < 0.001), and hs- CRP (r = +0.421 and p < 0.001). Mean concentration of serum visfatin was not significantly different between groups of MetS and PreDM. Conclusion: Visfatin was associated with body mass index and insulin resistance, but not with metabolic syndrome and impaired glucose metabolism.
On the Legitimacy of IS as an Independent Discipline: Research that Sets the Field Apart

Motivated by the continuing anxiety discourse within the IS field and the continuing disrespect IS researchers earn from scholars of other management disciplines, this essay discusses six areas in which IS researchers make unique knowledge contributions to management scholarship. More specifically, this essay suggests that information systems development, information systems adoption, organizational information systems innovation, group level resistance to IT implementations, the business value of IT, and Knowledge Management, among others, are all areas in which IS scholars can claim to contribute uniquely to the management body of knowledge. In so doing, this essay provides six robust arguments for IS scholars to concisely justify their field and research – and to be positive about the work they are doing. Perhaps even more importantly, this essay may motivate IS scholars to allocate their resources to topics that help increase the field‘s legitimacy.
The Open Access Israeli Journal of Aquaculture – Bamidgeh

The aim of this study was to determine the changes in the mRNA transcription levels of HSP70 and IGF genes related to stress and immunity in Oncorhynchus mykiss obtained from fish farms, to determine the phenotypic and antimicrobial properties of the bacteria isolated in the study and to compare the results according to different diseases. Accordingly, six fish from each fish farm, a total of 30 fish were sampled. Bacterial identification, inoculations were carried out from the tissue samples taken from the kidney and symptomatic surfaces of fish samples in TSA. Primary cultures were obtained after incubation periods at 21 and 37C. Gram staining, catalase, and oxidase tests were performed. Forty-six biochemical and 26 antimicrobial tests were performed using BD Phoenix ID Panels. Muscle tissue was used to determine mRNA gene expression differences and the tissues were preserved at -80°C in RNAlater storage solution. Following the RNA isolation and cDNA synthesis, a real-time PCR procedure was performed with b-Actin (ACTB), Insuline-like growth factor (IGF) and HSP70 Gene Primer Array system. Enterococcus faecium (E. faecium), Lactococcus garvieae (L. garvieae) and Staphylococcus aureus (S. aureus) agents were isolated in the study. These bacteria were identified with 91-99% similarity ratios. No disease agents in the gene expressions of the fish samples in were isolated and they were therefore used as controls. Compared to the control group, heat shock protein (HSP) mRNA expression was upregulated in fish tissues infected with E. faecium, S. aureus, and L. garvieae whereas no significant increase was determined in fish tissues infected with S. aureus. IGF mRNA gene expression was upregulated in all infected tissues. IGF expression was upregulated at the highest level in fish tissues infected with L. garvieae. Produced by the Society of Israeli Aquaculture & Marine Biotechnology. The IJA is an open-access, scientific journal, published on http://www.aquaculturehub. org/group/israelijournalofaqua culturebamidgehija To read papers free of charge, please register online at the above website. Sale of IJA papers is strictly forbidden.
Wine Funds: An Alternative Turning Sour?

This article examines the performance, selectivity, and market-timing abilities of wine fund managers over the 2000–2013 period. The authors hypothesize that wine fund managers should be able to profit from market inefficiencies on the wine market and generate abnormal returns for investors. Their results show that fund managers’ overall selectivity and market-timing abilities appear to be limited. Only one fund offers positive risk-adjusted returns and two funds show a tendency for market timing. Considering non-quantifiable risks, wine funds thus do not appear to be interesting investments.
Treatment with Statins in Elderly Patients

Elderly patients are a special category of patients, due to the physiological changes induced by age, the great number of comorbidities and drug treatment and last, but not least, to the cognitive dysfunction frequently encountered in this population. Cardiovascular disease is the most important cause of morbidity and mortality in elderly individuals worldwide. The rate of cardiovascular events increases after 65 years in men and after 75 years in women. Myocardial infarction and stroke are the leading disorders caused by atherosclerosis, that lead to death or functional incapacity. Elderly people have a greater risk to develop atherosclerotic cardiovascular disease. The incidence and prevalence of atherosclerosis increase with age and the number of cardiovascular events is higher in elderly patients. The most efficient treatment against atherosclerosis is the treatment with statins, that has been shown to decrease the risk both of stroke and coronary artery disease in all age groups. The advantages of the treatment become evident after at least one year of treatment. Primary prevention is the most important way of preventing cardiovascular disease in elderly individuals, by promoting a healthy lifestyle and reducing the risk factors. Secondary prevention after a stroke or myocardial infarction includes mandatory a statin, to diminish the risk of a recurrent cardiovascular event. The possible side effects of statin therapy are diabetes mellitus, myopathy, and rhabdomyolysis, hepatotoxicity. The side effects of the treatment are more likely to occur in elderly patients, due to their multiple associated comorbidities and drugs that may interact with statins. In elderly people, the benefits and disadvantages of the treatment with statins should be put in balance, especially in those receiving high doses of statins.
Mesoscopic Simulation of Aggregate Structure and Stability of Heavy Crude Oil by GPU Accelerated DPD

The aggregate structure of heavy crude oil, influencing the rheology, dispersity, stability of water-in-oil emulsions, attracts much industrial attention. In this work, aggregate behavior of asphaltenes in heavy crude oil was explored by a DPD based mesoscale platform. GPU was used to accelerate the simulation, which gains over 20x speedup against the serial version DPD provided by Materials Studio and over 10x speedup against the parallel version of DPD provided by CULGI running on 5 CPU cores. Rigid body fragments, which represent the significant presence of fused aromatic rings structure in fractions such as asphaltenes and resins, were introduced into DPD. During the simulation, face to face, offset and T-shaped asphaltene aggregate structures were observed. The interlayer distance in well-ordered structure obtained from simulation was near 0.36 nm no matter which kind of model molecules, which agreed with experimental data (Trejo et al, 2009) well. The cluster size of asphaltene molecules was used to represent the stability of crude oil, which show that the stability of crude oil was independent on the concentration of saturate or aromatic with enough resin; if there was not enough resin to disperse asphaltene clusters, the ratio of saturate/aromatic must be limited to low values to maintain the oil stable. The relationship between concentration and stability of crude oil was consistent with Shell's work (Stankiewicz, et al, 2002).
Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion.

BACKGROUNDInsulin resistance results from impaired skeletal muscle glucose transport/phosphorylation, linked to augmented lipid availability. Despite greater intramuscular lipids, athletes are highly insulin sensitive, which could result from higher rates of insulin-stimulated glycogen synthesis or glucose transport/phosphorylation and oxidation. Thus, we examined the time course of muscle glycogen and glucose-6-phosphate concentrations during low and high systemic lipid availability.METHODSEight endurance-trained and 9 sedentary humans (VO2 peak: 56 ± 2 vs. 33 ± 2 mL/kg/min, P < 0.05) underwent 6-hour hyperinsulinemic-isoglycemic clamp tests with infusions of triglycerides or saline in a randomized crossover design. Glycogen and glucose-6-phosphate concentrations were monitored in vastus lateralis muscles using 13C/31P magnetic resonance spectroscopy.RESULTSAthletes displayed a 25% greater (P < 0.05) insulin-stimulated glucose disposal rate (Rd) than sedentary participants. During Intralipid infusion, insulin sensitivity remained higher in the athletes (ΔRd: 25 ± 3 vs. 17 ± 3 μmol/kg/min, P < 0.05), supported by higher glucose transporter type 4 protein expression than in sedentary humans. Compared to saline infusion, AUC of glucose-6-phosphate remained unchanged during Intralipid infusion in athletes (1.6 ± 0.2 mmol/L vs. 1.4 ± 0.2 [mmol/L] × h, P = n.s.) but tended to decrease by 36% in sedentary humans (1.7 ± 0.4 vs. 1.1 ± 0.1 [mmol/L] × h, P < 0.059). This drop was accompanied by a 72% higher rate of net glycogen synthesis in the athletes upon Intralipid infusion (47 ± 9 vs. 13 ± 3 μmol/kg/min, P < 0.05). CONCLUSIONAthletes feature higher skeletal muscle glucose disposal and glycogen synthesis during increased lipid availability, which primarily results from maintained insulin-stimulated glucose transport with increased myocellular glucose-6-phosphate levels for subsequent glycogen synthesis.TRIAL REGISTRATIONClinicalTrials.gov NCT01229059.FUNDINGGerman Federal Ministry of Health (BMG).
Development of Holistic Episodic Recollection

Episodic memory binds the diverse elements of an event into a coherent representation. This coherence allows for the reconstruction of different aspects of an experience when triggered by a cue related to a past event—a process of pattern completion. Previous work has shown that such holistic recollection is evident in young adults, as revealed by dependency in retrieval success for various associations from the same event. In addition, episodic memory shows clear quantitative increases during early childhood. However, the ontogeny of holistic recollection is uncharted. Using dependency analyses, we found here that 4-year-olds (n = 32), 6-year-olds (n = 30), and young adults (n = 31) all retrieved complex events in a holistic manner; specifically, retrieval accuracy for one aspect of an event predicted accuracy for other aspects of the same event. However, the degree of holistic retrieval increased from the age 4 to adulthood. Thus, extended refinement of multiway binding may be one aspect of episodic memory development.
Evaluating case management as a complex intervention: Lessons for the future

The methodological challenges to effectiveness evaluation of complex interventions has been widely discussed. Bottom-up case management for frail older person was implemented in Belgium, and indeed, it was evaluated as a complex intervention. This paper presents the methodological approach we developed to respond to four main methodological challenges regarding the evaluation of case management: (1) the standardization of the interventions, (2) stratification of the frail older population that was used to test various modalities of case management with different risks groups, (3) the building of a control group, and (4) the use of multiple outcomes in evaluating case management. To address these challenges, we developed a mixed-methods approach that (1) used multiple embedded case studies to classify case management types according to their characteristics and implementation conditions; and (2) compared subgroups of beneficiaries with specific needs (defined by Principal Component Analysis prior to cluster analysis) and a control group receiving ‘usual care’, to evaluate the effectiveness of case management. The beneficiaries’ subgroups were matched using propensity scores and compared using generalized pairwise comparison and the hurdle model with the control group. Our results suggest that the impact of case management on patient health and the services used varies according to specific needs and categories of case management. However, these equivocal results question our methodological approach. We suggest to reconsider the evaluation approach by moving away from a viewing case management as an intervention. Rather, it should be considered as a process of interconnected actions taking place within a complex system.
A study of the incidence and mortality hazard rate of myocardial infarction in Tromsø

This thesis uses data from the Tromsø Study and weather data from the Norwegian Meteorological Institute to study the mortality hazard rate and incidence rate of myocardial infarction (MI) in Tromsø using a latent Gaussian modelling framework. Inference is performed using integrated nested Laplace approximations (INLA). This thesis presents the datasets and describes the modelling and computational framework, before analysis is performed. To study the mortality hazard rate after MI, a Cox proportional hazards model has been implemented. A model without a seasonal effect with sex as a stratum variable was deemed the best fit. The results show an increased risk in the month after a MI. After the first month, the risk drops, before it increases with age. The mortality hazard rate is slightly higher for men than for women. To study the change in the rate of MI during the time of the study, a Bayesian age-period-cohort model has been implemented. The model only includes the men of the study. This model studies the rate of MI on three different time scales: age, period, and cohort. The effects from age, period, and cohort are not directly identifiable. However, second differences describing the curvature and relative risk ratios are identifiable, as is the overall rate. The results show the incidence rate of MI decreasing with period, and increasing with age.
MicroRNAs in Uteroplacental Vascular Dysfunction

Pregnancy complications of preeclampsia and intrauterine growth restriction (IUGR) are major causes of maternal and perinatal/neonatal morbidity and mortality. Although their etiologies remain elusive, it is generally accepted that they are secondary to placental insufficiency conferred by both failure in spiral artery remodeling and uteroplacental vascular malfunction. MicroRNAs (miRNAs) are small no-coding RNA molecules that regulate gene expression at the post-transcriptional level. Increasing evidence suggests that miRNAs participate in virtually all biological processes and are involved in numerous human diseases. Differentially expressed miRNAs in the placenta are typical features of both preeclampsia and IUGR. Dysregulated miRNAs target genes of various signaling pathways in uteroplacental tissues, contributing to the development of both complications. In this review, we provide an overview of how aberrant miRNA expression in preeclampsia and IUGR impacts the expression of genes involved in trophoblast invasion and uteroplacental vascular adaptation.