Miracle-dz/UniFAR-FTUs huggingface dataset:
ESTADO NUTRICIONAL E CONSUMO ALIMENTAR DE ÁCIDOS GRAXOS EICOSAPENTAENÓICO E DOCOSAHEXAENÓICO ASSOCIADOS À FUNÇÃO COGNITIVA EM IDOSOS

RESUMO: O objetivo do presente estudo foi relacionar o estado nutricional, consumo adequado dos ácidos graxos ômega-3 eicosapentanóico (EPA) e docosahexaenóico (DHA) à capacidade cognitiva de idosos. A avaliação do estado nutricional foi realizada por meio da Área Muscular do Braço Corrigida. A avaliação do consumo alimentar por meio da aplicação do Recordatório 24 horas em três dias alternados, incluindo um dia de final de semana. Após dois meses o Recordatório 24 horas foi aplicado novamente durante 3 dias alternados, sendo um dia do final de semana. O consumo alimentar de EPA e DHA de acordo com os inquéritos foram calculados pelo software Dietpro 5i. Para a avaliação da capacidade cognitiva fez-se uso do Mini-Exame do Estado Mental (MEEM). De acordo com o teste, os idosos foram classificados em dois grupos: não apresenta distúrbio cognitivo e apresenta distúrbio cognitivo. O estado nutricional e o consumo de EPA e DHA foram associados ao estado mental dos idosos. Os dados foram analisados por meio do programa estatístico Statistical Package for Social Sciences – SPSS versão 20.0 para Windows. A estatística descritiva foi feita por meio de medidas de tendência central e dispersão (média e desvio padrão). Para realização da estatística inferencial, anormalidade dos dados foi testada a partir do Teste de Shapiro-Wilk e os pressupostos de força, assimetria e curtose foram correspondidos. Na sequência, foram aplicados Teste T para amostras independentes e ANOVA One Way, para verificar a diferença entre os grupos. Além disso, foi realizado o Qui Quadrado de Pearson, com intuito de avaliar a associação entre as variáveis de frequência. Foram avaliados ao fim do estudo 21 idosos, destes 71,4% pertencentes ao sexo feminino. Pode-se constatar que na população estudadada 58,8% dos indivíduos apresentavam estado nutricional inadequado. Verificou-se uma maior distribuição de inadequação do estado nutricional no grupo ADC (41,%) quando comparado ao grupo NADC (17,7%). Em relação ao consumo alimentar de EPA e DHA não foi possível estabelecer o consumo médio. Pode-se concluir ao fim da pesquisa que no grupo estudado havia uma alta prevalência de distúrbio cognitivo nos idosos e de um estado nutricional inadequado sobretudo no grupo masculino. O estado nutricional não está associado à capacidade cognitiva. Não foi possível correlacionar o consumo de EPA e DHA ao estado mental dos idosos uma vez que a dieta destes mostrou-se ausente nestes nutrientes, refletindo assim o baixo consumo destes ácidos graxos pela população.
Neurogenesis in the sea urchin embryo is initiated uniquely in three domains

ABSTRACT Many marine larvae begin feeding within a day of fertilization, thus requiring rapid development of a nervous system to coordinate feeding activities. Here, we examine the patterning and specification of early neurogenesis in sea urchin embryos. Lineage analysis indicates that neurons arise locally in three regions of the embryo. Perturbation analyses showed that when patterning is disrupted, neurogenesis in the three regions is differentially affected, indicating distinct patterning requirements for each neural domain. Six transcription factors that function during proneural specification were identified and studied in detail. Perturbations of these proneural transcription factors showed that specification occurs differently in each neural domain prior to the Delta-Notch restriction signal. Though gene regulatory network state changes beyond the proneural restriction are largely unresolved, the data here show that the three neural regions already differ from each other significantly early in specification. Future studies that define the larval nervous system in the sea urchin must therefore separately characterize the three populations of neurons that enable the larva to feed, to navigate, and to move food particles through the gut. Summary: Patterning signals in the three territories in which neurogenesis is initiated during sea urchin gastrulation differentially affect proneural expression of six transcription factors resulting in three unique specification trajectories.
The Generalizability of Randomized Controlled Trials of Self-Guided Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms: Systematic Review and Meta-Regression Analysis

Background Self-guided internet-based cognitive behavioral therapies (iCBTs) for depressive symptoms may substantially increase accessibility to mental health treatment. Despite this, questions remain as to the generalizability of the research on self-guided iCBT. Objective We sought to describe the clinical entry criteria used in studies of self-guided iCBT, explore the criteria’s effects on study outcomes, and compare the frequency of use of these criteria with their use in studies of face-to-face psychotherapy and antidepressant medications. We hypothesized that self-guided iCBT studies would use more stringent criteria that would bias the sample toward those with a less complex clinical profile, thus inflating treatment outcomes. Methods We updated a recently published meta-analysis by conducting a systematic literature search in PubMed, MEDLINE, PsycINFO, and EMBASE. We conducted a meta-regression analysis to test the effect of the different commonly used psychiatric entry criteria on the treatment-control differences. We also compared the frequency with which exclusion criteria were used in the self-guided iCBT studies versus studies of face-to-face psychotherapy and antidepressants from a recently published review. Results Our search yielded 5 additional studies, which we added to the 16 studies identified by Karyotaki and colleagues in 2017. Few self-guided iCBT studies excluded patients with severe depressive symptoms (6/21, 29%), but self-guided iCBT studies were more likely than antidepressant (14/170, 8.2%) studies to use this criterion. However, self-guided iCBT studies did not use this criterion more frequently than face-to-face psychotherapy studies (6/16, 38%). Beyond this, we found no evidence that self-guided iCBTs used more stringent entry criteria. Strong evidence suggested that they were actually less likely to use most entry criteria, especially exclusions on the basis of substance use or personality pathology. None of the entry criteria used had an effect on outcomes. Conclusions A conservative interpretation of our findings is that the patient population sampled in the literature on self-guided iCBT is relatively comparable with that of studies of antidepressants or face-to-face psychotherapy. Alternatively, studies of unguided cognitive behavioral therapy may sample from a more heterogeneous and representative patient population. Until evidence emerges to suggest otherwise, the patient population sampled in self-guided iCBT studies cannot be considered as less complex than the patient population from face-to-face psychotherapy or antidepressant studies.
Tell Me Before You Stream Me

Live streaming is a new media format that simultaneously records and broadcasts in real time, in multiple channels including video, audio, and text. A new application area of live streaming is in the video game community, where players stream their gameplay. Since most of the streamed games are team-based, one's live streaming may involve other players' gameplay and disclosure. In the present paper, we aim to understand the attitudes and strategies of players who have been streamed by others in video game live streaming. From an interview study with 20 World of Warcraft (WoW) players, we found that participants had concerns about being streamed due to different factors, and adopted individual and collaborative strategies to cope with their concerns. We discuss privacy challenges in live streaming and present design implications for live streaming tools to improve privacy management.
Natural Multi‐Target Inhibitors of Cholinesterases and Monoamine Oxidase Enzymes with Antioxidant Potential from Skin Extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)

Alzheimer's disease (AD) is the most common cause of dementia, characterized by loss of selective neuronal and normal brain functions. Every year, ten million new cases are diagnosed worldwide. AD is a complex disease associated with all kind of different pathways, making their simultaneous modulation necessary. Nowadays anti‐AD treatments are focused on enzymatic inhibitors. The study of the amphibians’ skin had acquired great importance in the fields of biology and human health and represents an attractive and novel source for natural compounds with high potential in the development of new drugs. The present work exhibits the power of amphibian skins as a source of bioactive compounds. Herein we report the activity of extracts of two species from Hylidae family (H. cordobae and P. minuta) as reversible inhibitors of acetylcholinesterase and butyrylcholinesterase enzymes. Furthermore, the extracts inhibit MAO−B enzyme and showed antioxidant activities, acting on four important pathways of AD.
The Influence of Minimal Misalignment on the Repeatability of PET Images Examined by the Repositioning of Point Sources

We aimed to evaluate the influence of minimal misalignment of a hot spot on the repeatability of PET images using repositioning of point sources. Methods: Point sources with an inner diameter of 1 mm were made with 1 μL of 18F solution. Seven point sources were placed on the x-axis in the field of view. For fixed-position imaging, PET data were acquired for 10 min 5 times serially. For variable-position imaging, PET data were acquired for 10 min each with the point sources placed at 0, ±0.5, and ±1.0 mm in the x-axis direction. The data were reconstructed using ordered-subsets expectation maximization (OSEM) and OSEM plus point-spread function (PSF). The image matrix was 128 × 128, 200 × 200, 256 × 256, 400 × 400, and 512 × 512 pixels. The normalized maximum count (rMax), the coefficient of variance (CVmax), and the full width at half maximum were analyzed. Results: The hot spots on OSEM images far from the center became faint and broad, whereas those on OSEM+PSF images became small and dense. Although rMax was overestimated at the 5-cm position on OSEM images, rMax at other positions was overestimated on OSEM+PSF images with a matrix of at least 256 × 256. rMax showed a similar pattern in fixed- and variable-position images. CVmax in fixed-position OSEM images was less than 2%, irrespective of matrix size. In contrast, CVmax in variable-position images was higher than in fixed-position images. CVmax was higher for OSEM+PSF images than for OSEM images. The full width at half maximum increased at positions far from the center on OSEM images but was stable at all positions on OSEM+PSF images. Conclusion: The repeatability of the small hot spot was affected by the minimal misalignment, especially on OSEM+PSF images. Precise positioning is necessary if PET is to be used as a biomarker. Professionals should recognize that PSF correction worsens the repeatability of the small hot spot although improving the spatial resolution of PET images.
Neutrophils and IL17A mediate flagellar hook protein FlgE‐induced mouse acute lung inflammation

Bacterial flagellar hook and recombinant flagellar hook protein E (FlgE) were reportedly immunostimulatory in mammalian cells or tissues. Current study focused on the mechanisms underlying FlgE stimulation. In an acute lung injury model induced by intranasal FlgE challenge, neutrophils were the predominant infiltrates in lungs, and depletion of neutrophils with anti‐Ly6G antibody attenuated FlgE‐induced lung damage. However, the FlgE‐induced neutrophils recruitment, neutrophils reactive oxygen species (ROS) generation, and neutrophil extracellular traps (NETs) formation were significantly impaired in Il17a−/− mice compared with those in wild‐type (WT) mice. In FlgE‐treated lung organoids and isolated neutrophils, the phosphorylation levels of signal transfer and activator of transcription protein 3 (STAT3), which was involved in neutrophils functions, were upregulated, but this upregulation was partly impaired upon IL17A deficiency or by IL6 neutralisation. When neutrophils isolated from WT mice were treated with FlgE, the expression of IL17A/IL17RC was increased, but the activation was blocked by STAT3 inhibitor. The NETs formation in FlgE‐treated neutrophils was not affected by the ROS inhibitor or recombinant IL17A alone but partly impaired in the presence of STAT3 pathway inhibition. In conclusion, we propose that the pro‐inflammatory activities of FlgE are mediated by activating STAT3 phosphorylation and IL17A/IL17R expression and by promoting a ROS‐independent NETs formation.
Usefulness of platelet to lymphocyte ratio for predicting recurrence of atrial fibrillation after direct current cardioversion

Atrial fibrillation (AF) is the most common cardiac rhythm disorder with the associated risks of stroke and mortality. The usefulness of platelet to lymphocyte ratio (PLR), a recently described inflammatory marker, in predicting adverse cardiovascular events has been demonstrated in several studies. In the current study, we investigated the role of PLR in predicting recurrence after successful electrical cardioversion (ECV) in patients with non‐valvular persistent AF.
Precipitable Water Vapour Retrieval from GPS Precise Point Positioning and NCEP CFSv2 Dataset during Typhoon Events

Radiosonde is extensively used for understanding meteorological parameters in the vertical direction. Four typhoon events, including three landfalls (MERANTI, NEPARTAK, and MEGI) and one non-landfall (MALAKAS), were chosen in analysing the precipitable water vapour (PWV) characteristics in this study. The spatial distribution of the three radiosonde stations in Zhejiang province does not meet the requirement in analysing changes in PWV during typhoon event. Global position system (GPS) observations are an alternative method for deriving the PWV. This enables improvements in the temporal–spatial resolution of PWV computed by the radiosonde measurements. The National Centers for Environmental Prediction (NCEP) re-analysed data were employed for interpolating temperature and atmosphere pressure at the GPS antennas height. The PWV computed from GPS observations and NCEP re-analysed data were then compared with the true PWV. The maximum difference of radiosonde and GPS PWV was not more than 30 mm at Taiz station. The Root-Mean-Square (RMS) of PWV differences between radiosonde and GPS was not more than 5 mm in January, February, March, November, and December. It was slightly greater than 5 mm in April. High RMS in May, June, July, August, September, and October implies that differences in GPS and radiosonde PWVs are evident in these months. Correlation coefficients of GPS and radiosonde PWVs were more than 0.9, indicating that the changes in GPS and radiosonde PWVs are similar. Radiosonde calculated PWVs were used for GPS PWV calibration for understanding the PWV changes during the period of a typhoon event. The results from three landfall typhoons show that the average PWV over Zhejiang province is increasing and approaching China mainland. In contrast, MALAKAS did not make landfall and shows a decreasing PWV trend, although it was heading to China mainland. Generally, the PWV change can be used to predict whether the typhoon will make landfall in these cases. PWV spatial distribution of MERANTI shows that PWV peaks change along the typhoon epicenter over Zhejiang province.
Gene exchange between two divergent species of the fungal human pathogen, Coccidioides

The fungal genus Coccidioides is composed of two species, Coccidioides immitis and Coccidioides posadasii. These two species are the causal agents of coccidioidomycosis, a pulmonary disease also known as valley fever. The two species are thought to have shared genetic material due to gene exchange in spite of their long divergence. To quantify the magnitude of shared ancestry between them, we analyzed the genomes of a population sample from each species. Next, we inferred what is the expected size of shared haplotypes that might be inherited from the last common ancestor of the two species and find a cutoff to find what haplotypes have conclusively been exchanged between species. Finally, we precisely identified the breakpoints of the haplotypes that have crossed the species boundary and measure the allele frequency of each introgression in this sample. We find that introgressions are not uniformly distributed across the genome. Most, but not all, of the introgressions segregate at low frequency. Our results show that divergent species can share alleles, that species boundaries can be porous, and highlight the need for a systematic exploration of gene exchange in fungal species.
Impact of red blood cell transfusions on intestinal barrier function in preterm infants.

OBJECTIVE To determine the relationships of red blood cell (RBC) transfusion and enteral feeding to changes in intestinal permeability (IP) measured by the relative intestinal uptake of lactulose (La) and rhamnose (Rh) in preterm infants <33 wk gestation. DESIGN/METHODS Infants 240-326wk gestation received La/Rh solution enterally on study days 1, 8 and 15.Urinary La/Rh ratio was measured by HPLC. Hematocrit preceding transfusion, total RBC transfusion volume, volume/kg, and feeding status during each study interval (birth-d1; d1-d8, and d8-d15) were determined. RESULTS Of the seventeen (40.5%) subjects who received≥1 transfusion during the study period, 12 (70.6%) infants were <28 wk gestation and 5 (29.4%) infants were≥28 wk gestation, p < 0.0001. Lower pre-transfusion hematocrit was observed in intervals preceding high IP (La/Rh > 0.05) than in intervals preceding low IP (La/Rh≤0.05) measurements (33 vs 35.8, p = 0.1051). RBC transfusions occurred more frequently in intervals preceding high IP than in intervals preceding low IP (26.8%; vs 8.3%, p = 0.0275) with 5-fold higher total RBC volume and volume/kg in intervals preceding any time point with high IP. RBC transfusion during an interval was associated with a three-fold increased risk of high IP (aOR 2.7; 95% C.I 0.564-12.814; p = 0.2143). Exclusive breast milk exposure and post-menstrual age reduced the risk for high IP following RBC transfusion. CONCLUSIONS Both RBC transfusion number and volume was associated with subsequent high IP measurements in preterm infants <33 weeks gestation and potentially may contribute to impairment of the preterm intestinal barrier.
Customer Purchase Intentions and Choice in Food Retail Environments: A Scoping Review

Food purchasing and consumption behaviors have implications for nutrition and obesity. Food retail environments, in particular, shape customer food choices and energy intake. The marketing literature offers insights about how public health practitioners can work within food retail environments to encourage healthy food choices. We reviewed experimental studies in the marketing literature to examine factors influencing customer purchase intentions and choice for food products in retail stores. Database searches were conducted in February 2016 for original, empirical articles published in English from 2000–2015 in marketing journals. Each research article included at least one experimental design study conducted in a real or simulated retail environment with purchase intentions or choice of food products as an outcome variable. Backward and forward reference searches were conducted for articles meeting inclusion criteria. Narrative synthesis methods were used to thematically group and summarize the findings of forty-one articles that met inclusion criteria into three categories: shelf display and product factors, pricing and price promotion factors, and in-store and customer decision-making factors. This research contributes to the literature by providing specific and actionable approaches that can increase/decrease customer purchase intentions and choice for food products in retail environments. Translating marketing strategies into public health applications can provide recommendations for future intervention research and policy related to customer food purchasing behavior.
Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients

Background: Heart failure with preserved ejection fraction (HFpEF) is characterized by heart failure symptoms and structural change (including fibrosis). The relationship between novel biomarkers and the above components remains unclear. Methods: Seventy-seven HFpEF patients were recruited. All patients underwent echocardiography with tissue doppler imaging, cardiac magnetic resonance imaging (CMRI), and measurement of plasma inflammatory, remodelling, endothelial function, and heart failure biomarker levels. Myocardial fibrosis was defined by CMRI-extracellular volume. Forward conditional logistic regression was applied to demonstrate the determinants of myocardial fibrosis or heart failure symptoms. Results: The levels of growth differentiation factor, tissue inhibitor of metalloproteinase (TIMP)-1, galectin-3, and N-terminal pro b-type natriuretic peptide (NT-proBNP) were significantly higher in patients with more myocardial fibrosis. Matrix metalloproteinase-2 (MMP-2) and galectin-3 were independent markers of ECV. After adjusting for confounding factors, plasma galectin-3 and MMP-2 levels were correlated with myocardial fibrosis levels (odds ratio (OR): 1.05, 95% confidence interval (CI): 1.02 to 1.09, p = 0.005 and OR: 2.11, 95% CI: 1.35–3.28, respectively), while NT-proBNP level only was associated with heart failure symptoms. We developed a score system consisted of biomarkers and clinical parameters. The area under the curve of the scoring system receiver operating characteristic curve is 0.838 to predict the degree of myocardial diffuse fibrosis. Conclusions: In conclusion, we found that galectin-3 and MMP-2 were significantly associated with global cardiac fibrosis in HFpEF patients. We also combined plasma biomarkers and clinical data to identify HFpEF patients with more severe cardiac fibrosis.
Diagnóstico de la fertilidad de los suelos de cuatro municipios de Cundinamarca (Colombia) para la producción de plátano

To achieve optimum yields in plantain production, appropriate fertilization plans must be adjusted, for which the availability of nutrients in the soil must be taken into account. In order to contribute to the study of the fertility of soils cultivated with cooking banana in the province of Cundinamarca - Colombia, a chemical characterization of soils was carried out in four of the main producing municipalities. 146 farms located in Viota, La Vega, La Palma and Chaguani, were visited, and soil samples were taken for chemical analysis. The results obtained were subjected to a frequency analysis, Pearson’s linear correlation and main components; fi nally making a comparison of means between the four municipalities. Low levels of P, S and Mg, medium of K, Ca and B were observed, as well as high concentrations of Zn that can be toxic for the plantain crop. On the other hand, the variables were grouped into four components associated with: the soil change layer, the soil reaction, the salinity and the relationship between P and Zn. Soils of the municipalities of La Vega and La Palma did not show variation in the change layer and soil reaction, contrary to that observed in Viota and Chaguani soils. Among the soils of the municipalities, there were significant differences for the properties of organic matter, Ca and Mg as well as cationic imbalances and strongly acidic pH.