Miracle-dz/UniFAR-FTUs huggingface dataset:
Theories of Vigilance and the Prospect of Cognitive Restoration

Effectively mitigating the vigilance decrement (the decrease in performance on tasks requiring sustained attention over time) is one of the most important human factors problems studied today. Despite this, the underlying theory of vigilance and its failings are still disputed. The two primary theories espoused by researchers today are a cognitive resource theory of vigilance and a mindlessness theory of vigilance. This literature review examines the literature investigating points of conflict between these theories, revealing that the majority of experimental research supports a cognitive resource theory of vigilance. Additionally, we examine research investigating the effect of active rest breaks on cognitive and affective restoration. The literature available on cognitive restoration does not support the suggestion that active rest breaks help restore vigilance-relevant cognitive resources more effectively than passive rest breaks. The research does however, support the proposition that more active rest breaks can reduce stress and increase affect. The potential for increasing worker well-being with more active breaks warrants additional research.
Locking Range Maximization in Injection-Locked Class-E Oscillator—A Case Study for Optimizing Synchronizability

We propose a method for designing optimal external forcings of injection-locked oscillators. This method enables to maximize the locking range of general injection-locked oscillators under certain practical constraints that encompass the power, magnitude, or area of forcing waveforms. Here, as a case study, we focus on a class-E oscillator in the injection-locked mode, for which we obtain the following systematic results. First, by using the proposed method, the optimal waveform of external forcings is obtained analytically under three different constraints, i.e., the power- (i.e., root mean square-) reduced, magnitude-reduced, and area-reduced constraints. Second, through systematic circuit simulations, those predicted optimal forcings are verified to outperform any other forcings. Third, circuits experiments confirm that the theoretical predictions and the circuit simulation results are correct and consistent, regarding lock range maximization. These findings result in a first demonstration of locking range maximization for practical electrical oscillators.
Rs1894720 polymorphism is associated with the risk of age-related cataract by regulating the proliferation of epithelial cells in the lens via the signalling pathway of MIAT/miR-26b/BCL2L2

Introduction Cataracts caused by old age are one of the most frequent causes for blindness and poor vision worldwide. In this study, we aimed to clarify the possible role of rs1894720 polymorphism in the pathogenesis of age-related cataract. Material and methods Rs1894720 polymorphism genotype was detected by TaqMan. Bioinformatics analysis, luciferase assay, real-time PCR, western blot, and protein density analysis were conducted to establish the correlations between MIAT and miR-26b as well as between BCL2L2 and miR-26b. Flow cytometry and MTT assay were also performed to observe the effect of MIAT/miR-26b/BCL2L2 signalling pathway on the status of cell apoptosis and viability. Results MIAT functioned as an endogenous competing RNA to sponge miR-26b. In addition, BCL2L2 was identified as a target of miR-26b. Therefore, the expression of miR-26b was obviously suppressed by MIAT or anti-miR-26b, while the mRNA and protein expression of BCL2L2 was up-regulated in the presence of MIAT or anti-miR-26b. Moreover, the positive effect of MIAT on BCL2L2 expression was exerted via inhibition of the expression of miR-26b. In addition, the cells transfected with MIAT or anti-miR-26b showed suppressed expression of caspase-3 and reduced apoptosis index but higher cell viability, indicating that MIAT could suppress cell apoptosis via inhibition of miR-26b expression. Furthermore, the subjects carrying the GT and TT genotypes of single-nucleotide polymorphism (SNP) rs1894720 were associated with a higher risk of age-related cataracts, as indicated by their odds ratio (OR) and p-values. Conclusions Rs1894720 SNP could down-regulate the expression of MIAT, thus leading to reduced BCL2L2 expression and enhanced epithelial cell apoptosis in the lens, eventually increasing the incidence of age-related cataract.
Green Strategies to Printed Sensors for Healthcare Applications

Abstract Printed sensors have been explored for more than two decades and have now gained significant interest in real-world applications due to low cost, simple and scalable fabrication processes. These sensors must satisfy the requirement of long-term usage as wearable devices, especially for health monitoring and rehabilitation purposes. However, when such devices are continuously worn on the body or implanted within the body, they may cause unexpected risk to the patient’s health. To avoid potential health risks, transition to ‘green’ strategies has already begun in the research, design and manufacturing of these sensors. This review is dedicated to offering a snapshot of current realization and future prospects of printed sensors through green strategies. The utilization of eco-friendly and cost-effective materials for sensor components and the adoption of various printing methods are summarized. The reusability and multi-detection capability of printed sensors that are within the scope of green analytical chemistry are discussed.
Law of the Iterated Logarithm and Model Selection Consistency for Independent and Dependent GLMs

We study the law of the iterated logarithm (LIL) for the maximum likelihood estimation of the parameters in the generalized linear models with independent or weakly dependent ($\rho$-mixing, $m$-dependent) responses under mild conditions. The LIL is useful to derive the asymptotic bounds for the discrepancy between the empirical log-likelihood function and the true log-likelihood. As the application of the LIL, the strong consistency of some penalized likelihood based model selection criteria can be shown. Under some regularity conditions, the model selection criterion will be helpful to select the simplest correct model almost surely when the penalty term increases with model dimension and the penalty term has an order higher than $O({\rm{loglog}}n)$ but lower than $O(n)$. Simulation studies are implemented to verify the selection consistency of BIC.
Differential game theory with FPA optimization in multi-area power system

The distribution generation penetration increases due to the increased need of power. These penetration causes problem of frequency deviations. In this paper the in multi-area power system the combination of renewable energy resources is proposed. Here the area 1 & area 2 are thermal power plant. Hydro power generation plant is taken in area-3 & area-4. Renewable energy system is considered in area-5. Here the cyber security attack is taken as change in power in the entire area. This can make the power block out or wrong data entry. Here differential game theory-based problem formulation is done. The PI controller and differential game theory with flower pollination are compared for performance of fast response. The MATLAB 2017b is used for building the areas and algorithm
The interplay between DNA topoisomerase 2α post-translational modifications and drug resistance

The type 2 DNA topoisomerases (Top2) are conserved enzymes and biomarkers for cell proliferation. The catalytic activities of the human isoform Top2α are essential for the regulation of DNA topology during DNA replication, transcription, and chromosome segregation. Top2α is a prominent target for anti-cancer drugs and is highly regulated by post-translational modifications (PTM). Despite an increasing number of proteomic studies, the extent of PTM in cancer cells and its importance in drug response remains largely uncharacterized. In this review, we highlight the different modifications affecting the human Top2α in healthy and cancer cells, taking advantage of the structure-function information accumulated in the past decades. We also overview the regulation of Top2α by PTM, the level of PTM in cancer cells, and the resistance to therapeutic compounds targeting the Top2 enzyme. Altogether, this review underlines the importance of future studies addressing more systematically the interplay between PTM and Top2 drug resistance.
A rare case of acute paraplegia: primary Ewing’s Sarcoma of dorsal spine

Primary malignant sarcomas of the spine are rare, and they account for only 3.5%-14.9% of all primary bone sarcomas. Ewing's sarcoma is the second most common primary bone tumor in pediatric patients accounting for approximately 4% of pediatric malignancies. Its incidence is highest in the second decade of life and most commonly involves the long bones of the extremities and the pelvis, presenting primarily as swelling with pain. Primary vertebral Ewing's sarcoma has been divided into sacral and nonsacral types based on the differences in the treatment responses and survival rates. Primary involvement of the nonsacral spine represents approximately 0.9% of all cases. Low back pain is the most common symptom followed by a palpable swelling. Spinal cord compression can produce neurological deficits depending on the tumor location but is often a delayed presentation. Rapidly progressing paraplegia is uncommon and a high index of suspicion is essential for diagnosis, especially in a young patient. We report a rare case of dorsal spine Ewing's sarcoma that presented with acute onset paraplegia and improved with radical tumor decompression. Ewing’s sarcoma in the sacral spine is common but in the nonsacral spine is very rare accounts to 0.9%.
ASSESSMENT THE EFFECT OF FAMILY CENTERED CARE EDUCATIONAL PROGRAM ON HOME CARE KNOWLEDGE AMONG CARE GIVERS OF PATIENTS WITH CHRONIC RENAL FAILURE UNDER HEMODIALYSIS

Family members are one of the essential components of care for patients with chronic diseases such as chronic renal failure. Training caregivers and family members can increase patients quality of life and prevent readmission of them. this study aimed to determine the effectiveness of family centered care educational programs on home care knowledge of caregivers of patients with chronic renal failure undergoing hemodialysis in urmia Imam Khomeini and Taleghani Hospitals. Materials & Methods: This study is a quasi-experimental study. Total of 120 caregivers of patients with chronic renal failure undergoing hemodialysis with simple random sampling in Taleghani and Imam Khomeini Hospital were chosen. And were classified to the four group including: class education, booklet education, booklet and class education and the control group. At first step caregivers knowledge was measured using a researcher made questionnaire, then home care program for caring hemodialysis patients was conducted for caregivers, and After two months caregivers knowledge was assessed using the same questionnaire. Collected data were analyzed using descriptive and analytical statistical procedures and by SPSS v16 software. Results: The results of the study showed that the mean scores in all dimensions in each group before the intervention was not significantly different. mean scores differences between the samples Showed that experimental groups caregivers Knowledge mean scores in all dimensions after the intervention was greater than control group. And this increase in all dimensions after the intervention was statistically significant. General knowledge scores differences samples Showed that General knowledge mean scores among all groups increased after the intervention. This increase in General knowledge was statistically significant (P=0/000). Conclusion: Considering the results of this study it can be concluded that family-centered care education is effective in promotion knowledge of hemodialysis patients caregivers. Family-centered care can improve the physical and psychological aspect of patients with renal failure and enhance the quality of life for patients
Assessment of unconsciousness during carbon dioxide stunning in pigs

The aim of this study was to assess unconsciousness in pigs during exposure to CO2 through changes in the middle latency auditory evoke potentials (MLAEP) of the central nervous system (CNS), blood parameters (pH, carbon dioxide partial pressure [pCO2], oxygen partial pressure [pO2], oxygen saturation [SatO2] and bicarbonate [HCO−3]), behaviour and the corneal reflex. The MLEAP did not decrease significantly until after 60 s exposure to CO2. The blood parameters (decreased pH, pO2 and SatO2 and increased pCO2 and HCO3) changed 53 s after the onset of immersion. The burst suppression index (BS%) and the A-line ARX index (AAI) from the MLEAP recovered basal levels at 136 and 249 s, respectively. The first blood parameter to return to basal levels was HCO−3 at 76 s of exposure, followed by SatO2 at 180 s, pH and pO2 at 210 s and pCO2 at 240 s. During exposure to the gas, pigs exhibited lateral head movements and sneezing (10.3 s), gasping (23.5 s) and vocalisation (26.1 s). Furthermore, all pigs demonstrated muscular excitation after between 19 and 39 s exposure, when the AAI and BS% values were not significantly different from basal values. It was suggested, therefore, that these excitatory movements represent conscious movement, indicative of aversion to the gas. According to our results, loss of consciousness began, on average, after 60 s inhalation of 90% CO2. During exposure to the gas, decreased brain activity was seen, immediately following the changes in blood parameters. Following exposure, the restoration of blood parameters to basal levels allows a return to normal brain activity.
Connectés et Heureux - Du Stress Digital au Bien-être Numérique

A l’oppose de nombreux discours actuels, des chercheurs expliquent, preuves a l'appui, que les ecrans (smartphone, tablette, Internet, reseaux sociaux, series tele, jeux video…) ont des effets positifs et un potentiel considerable pour ameliorer notre sante et notre bien-etre, a condition de savoir comment bien les utiliser. Si les etres humains veulent acceder a plus de bonheur a l'air numerique, ils doivent developper un nouveau type d'intelligence : l'intelligence numerique. Ce livre fait un point sur les dernieres recherches scientifiques pour permettre d'ameliorer notre intelligence numerique de facon a bien utiliser au quotidien les technologies de la communication. D'abord, l’ouvrage explique comment se premunir des nombreux effets et relations (liens) deleteres qu’elles entretiennent : stress, anxiete, addiction aux ecrans, nomophobie, FOMO, isolement social, hyper narcissisme et jalousie numeriques, prise de poids, troubles de l'attention et du sommeil, et meme depression. Ensuite, le livre indique comment utiliser les ecrans pour ameliorer sa sante et son bien-etre au quotidien, developper ses forces de caracteres, donner davantage de sens a sa vie et mieux vivre ses relations aux autres, avec ou sans ecrans interposees. Bref, pour retrouver le « chemin du bonheur », tout en etant connecte.
Self-Care Management Behavior of Type 2 Diabetes Mellitus Patients in Indonesian Diabetes Association (Persadia) Depok City

Objective: Type 2 diabetes mellitus (type 2 diabetes) is a chronic disease that requires long-term management throughout the life to prevent acute and chronic complications. Self-care is a fundamental and integral part of diabetes management. Social support obtained from family, health professionals, friends, or diabetic peers may predict good self-care behavior. The purpose of this study was to evaluate the self-care behavior of adult with type 2 DM in Persadia Depok. Methods: This quantitative study used a cross-sectional design. A consecutive sample of 52 subjects with type 2 DM who joined in Persadia Depok was included. The instrument used to measure self-care behavior is The Summary of Diabetes Self-Care Activities questionnaire Results: The results showed that self-care behavior of participants in the last seven days is 4,4 days (Median 4.4, Minimal-Maximum 2.6-5.4, 95% CI 4.1-4.5). Self-care was described as “good” in only half of the participant (50%). Self-care behavior was reported good in diet, physical exercise, and taking medication, but it was poor in selfmonitoring of blood glucose (SMBG) and foot care. Conclusion: This study recommended that nurses should enhance education and support to improve patient self-care behaviors especially SMBG and foot care.
Investigating the relationship between Iranian EFL learners’ use of language learning strategies and foreign language skills achievement

Abstract This mixed methods study aimed at examining the relationship between EFL learners’ use of language learning strategies and the extent to which they achieved foreign language skills, namely writing, reading, listening, and speaking. The study also sought to identify possible differences between high and low achieving language learners regarding the frequency and type of their language learning strategies. To this end, the Strategy Inventory for Language Learning (SILL) (Oxford, 1990) was administered to 120 Iranian EFL learners. Likewise, a series of semi-structured interviews was conducted to explore their perceptions of the relationship between their use of language learning strategies and the achievement of the four language skills. The results of the qualitative analysis verified those of the quantitative data, and indicated that a substantial majority of EFL learners perceived the use of language learning strategies as advantageous. However, minor discrepancies were observed not only in the frequency of strategies employed by high and low achievers in the learning of writing, reading, listening, and speaking, but also in the type of learning strategies they utilized while learning the four language skills. Furthermore, our results demonstrated that high achievers mostly employed compensation, affective, and cognitive strategies, whereas low achievers drew on social, metacognitive, and memory strategies more frequently than other strategies. This study holds significant implications for EFL teachers to integrate strategy training into their instruction in the classroom. Informed of the repertoire of strategies used by high language achievers, EFL teachers can encourage language learners to use these strategies to enhance their language learning skills.
Oral squamous cell carcinoma - A case report

Oral Cancer is the 6 most common cancer globally, More than 90% cases are squamous cell carcinoma. The incidence of OSCC in Southeast Asia and South Central Asia is reported to be more with habits like Pan chewing, tobacco chewing and diet low in fresh vegetables and fruits. The common predisposing factors in developed countries are tobacco and alcohol. Here we present a case report of OSCC with absence of the common predisposing factors.
Can a small leak sink a great ship? A comprehensive analysis of the Portuguese household savings

The household saving rate is slowing down since the mid-1980s and in 2018 registered a record low. This article aims to contribute to the debate on the evolution of household savings in Portugal by considering both the microeconomic behaviour and the macroeconomic dynamics of household savings. First, we use microdata from the Household Finance and Consumption Survey (HFCS) to empirically assess the main microeconomic determinants of household savings, the heterogeneity across households regarding different ways of financing negative savings, and the main factors determining liquidity constrained agents. Second, we develop a time-series model for aggregate consumption to forecast the household saving rate in Portugal. We found household characteristics and heterogeneity regarding individual variables to be significant and economically important determinants of household saving decisions and credit constraints. Moreover, our out-of-sample forecast suggests there was no structural change in household savings decisions, indicating that the unexpected rise in the Portuguese household saving rate during the 2008 recession was led by temporary shocks to income and wealth.
Evaporation From the Southern Ocean Estimated on the Basis of AIRS Satellite Data

Evaporation plays an important role in the global water and energy cycles and, hence, in climate change. Evaporation over the Southern Ocean, where the Antarctic sea ice coverage has a large annual cycle, is poorly quantified. In this study, daily evaporation is estimated for the Southern Ocean with a sea‐ice‐specific algorithm, using surface temperature and air humidity from National Aeronautics and Space Administration's Atmospheric Infrared Sounder (AIRS), and wind speeds from Modern‐Era Retrospective Analysis for Research and Applications, Version 2 (MERRA‐2), reanalysis during 2003–2016. An uncertainty of 34% was found in the evaporation product. The results indicate that annual evaporation has considerable interannual and regional variability, but with a decreasing trend during the study period over most of the Southern Ocean. There are, however, areas where evaporation has increased, specifically in the Ross Sea in winter and summer, with smaller positive trends in spring and fall. Overall, the changes in the difference between the surface specific humidity and the air specific humidity, and to a much lesser extent in the wind speed, are the main drivers for the changes in evaporation throughout the year. During spring and fall months, changes to the sea ice cover, which alter the surface specific humidity, are the main drivers for the change, but in summer and winter the main driver is the air‐specific humidity. Air masses originating from the Antarctic continent (south) are associated with cold and dry conditions, which increase evaporation, whereas air masses from lower latitudes in the Southern Ocean (north) are associated with warm and moist conditions, decreasing evaporation. Comparisons with other reanalysis evaporation products produce similar trends, although annual averages differ.