Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of Coelenterazine Analogue to Reveal Bioluminescent Reaction of Human Serum Albumin

This chapter describes the design of an imidazopyrazinone-type luciferin named as HuLumino1 by us and investigation of its luminescence properties. This luciferin was designed to generate bioluminescence by human serum albumin (HSA) rather than by luciferase derived from luminous organisms. HuLumino1 was developed by modifying a methoxy-terminated alkyl chain to the C-6 position and eliminating a benzyl group at the C-8 position of coelenterazine. To clarify the basis of light emission by HSA, the detailed kinetic properties of the HuLumino1/HSA pair were investigated using a calibrated luminometer. The enzymatic oxidation of HuLumino1 was observed only in the presence of HSA. Results of HSA quantification experiments using HuLumino1 agreed with less than 5% differences with those of enzyme-linked immunosorbent assays, suggesting HuLumino1 could be used for quantitative analysis of HSA levels in serum samples without any pretreatments. These results demonstrate the advantages of the coelenterazine analogue as a bioluminescence reagent to detect non-labeled proteins, which generally do not function as enzymes.
Expected mean square rate estimation of repeated measurements model

In this paper, we obtained the estimation corresponding to the expected mean square rate of repeated measurement model depend on maximum likelihood method (MLM), restricted maximum likelihood method (REMLM) and modi ed restricted maximum likelihood method (MREMLM), and got eight cases that were classified into three types.
Cyclic(Alkyl)(Amino)Carbene Ligands Enable Cu-Catalyzed Markovnikov Protoboration and Protosilylation of Terminal Alkynes: A Versatile Portal to Functionalized Alkenes.

Regioselective hydrofunctionalization of alkynes represents a straightforward route to access alkenyl boronate and silane building blocks. In previously reported catalytic systems, high selectivity is achieved with a limited scope of substrates and/or reagents, with general solutions lacking. Herein, we describe a selective copper-catalyzed Markovnikov hydrofunctionalization of terminal alkynes that is facilitated by strongly donating cyclic (alkyl)(amino)carbene (CAAC) ligands. Using this method, both alkyl- and aryl-substituted alkynes are coupled with a variety of boryl and silyl reagents with high α-selectivity. The reaction is scalable, and the products are versatile intermediates that can participate in various downstream transformations. Preliminary mechanistic experiments shed light on the role of CAAC ligands in this process.
Antibiogram of Pseudomonas species: an important tool to combat antibiotic resistance for patient safety in Gombe, Nigeria

Background: Pseudomonas species are responsible for different healthcare-associated infections and are inherently resistant to many commonly used antibiotics. Hospital antibiograms are either absent or not regularly available in most healthcare facilities in Nigeria. The objective of this study is to present the antibiogram of Pseudomonas isolates in Federal Teaching Hospital Gombe (FTHG) in order to guide antibiotic prescription for better patient safety in the hospital. Methodology: The is a hospital-based cross-sectional study. A total of 4309 bacterial isolates were recovered from aerobic cultures of routine clinical specimens including urine, sputum, blood, swabs, aspirates, biopsies, seminal fluids and cerebrospinal fluids at the Medical Microbiology laboratory of the hospital between January and December 2019. Pseudomonas species were identified by colony morphology, Gram-reaction and conventional biochemical tests. Antibiotic susceptibility testing was performed on each Pseudomonas isolate using the modified Kirby-Bauer disk diffusion method on Mueller-Hinton agar and results interpreted according to the guideline of the Clinical and Laboratory Standards Institute (CLSI). Data were analysed using the Statistical Package for Social Sciences (SPSS) software version 23.0. Results: Of the total 4309 bacterial isolates, 436 (10.1%) Pseudomonas species were identified, with majority (49.8%) from urine specimens. Antibiotic susceptibility test results revealed average susceptibility rates of 73.8%, 70.1%, 66.2%, 59.5%, and 34.3% to ciprofloxacin, gentamicin, levofloxacin ceftazidime, and carbenicillin respectively. These rates fluctuate only slightly for each of the antibiotic during the 12 months period of survey. Conclusion: Pseudomonas species were most sensitive to ciprofloxacin and gentamicin among the first line antibiotics in FTHG in 2019. Regular updates and presentation of hospital antibiogram especially for intrinsically resistant bacteria such as Pseudomonas involved in healthcare associated infections, is an important tool in combating antimicrobial resistance and ensuring patient safety.
Triptolide Alleviates Murine Arthritis by Inhibiting Osteoclast Differentiation via TRAF6/MAPKs/NFATc1 Signaling Pathway

Background: Bone erosion is an important problem in rheumatoid arthritis (RA). The role of osteoclast in bone resorption is critical in RA, and intervention of osteoclast differentiation can improve bone destruction. Tripterygium wilfordii Hook F (TW) can improve the symptoms of RA. The effect of triptolide (TP), which is a purified component of TW, on bone destruction in RA and its mechanism remain unclear. Methods: We investigated the effect of TP on osteoclast differentiation using a co-culture system of synovial fibroblasts and monocytes from adjuvant-induced arthritic rats. We also investigated the effect of TP on murine collagen-induced arthritis (CIA). Results: The results showed that a certain dose of TP inhibited the differentiation of osteoclast, and reduced the levels of interleukin (IL)-1, IL-34, macrophage colony stimulating factor (M-CSF), receptor activator for nuclear factor-κ B Ligand (RANKL), and osteopontin (OPN) in the co-culture supernatant of synovial fibroblasts and monocytes. Furthermore, a certain dose of TP reduced the expression of tumor necrosis factor receptor-associated factor 6 (TRAF6), mitogen-activated protein kinases (MAPKs) and nuclear factor of activated T cells 1 (NFATc1) in osteoclast. Meanwhile, TP reduced the symptoms of arthritis and bone destruction in CIA. Conclusion: Our results suggest that TP can improve the bone destruction of murine arthritis, and the mechanism is related to the inhibition of osteoclast differentiation via TRAF6/MAPKs/NFATc1 signaling pathway.
FAKE NEWS DETECTION USING VARIOUS MACHINE LEARNING TECHNIQUES

Online platforms are being used for outspreading malicious talk, which creates an impact on the minds of millions. Many distinct approaches have been brought forward to detect this fake news, but very few have been carried out in the actual world. We address this problem of estimating the rumor authentication in a real-world in less time with significantly high accuracy. We design and implement an approach addressing the above issue. We accessed whether the news is fake or not using various Machine learning techniques. We evaluate this algorithm on a set of data set scrapped from random online sites. The result shows that the performance of this improved algorithm is better than the original classification method. And finally, we consider various sizes of data to view and compare the accuracy. KEYWORDS—Support Vector Machine, Decision Tree, Fake Content, Naive Bayes, Machine Learning Models
Media coverage and public perceptions of the THAAD event in China, the United States, and South Korea: a cross-national network agenda-setting study

Based on original data gathered from China, the United States, and South Korea, this study explores the relationship between media representations and public opinions concerning the deployment of the Terminal High Altitude Area Defense (THAAD) system in South Korea. Further, this study validates the network agenda-setting (NAS) model in multiple social contexts. This study’s supportive results confirm the NAS effects on both implicit and explicit public agendas, further expanding current NAS research. From a cross-nationally comparative perspective, this study investigates how NAS effects vary across countries, which is particularly important in the age of globalization, offering valuable contributions to an improved understanding of the NAS model. The study’s findings illustrate substantial differences between media agendas and variations in the NAS effects across countries, providing empirical evidence of national traits as potential contingent agenda-setting conditions.
Catecholamine Concentrations during and after Retroperitoneoscopic Adrenalectomies in Surgeon, Anaesthetist and Patients – how is physiological stress different from pathophysiological stress?

Background: During resections of phaeochromocytoma release of catecholamines can lead to excessive hypertension and arrhythmia. Therefore, these procedures can be stressful to surgeons and anaesthetists. It is completely unknown, how the excessive catecholamine concentrations in phaeochromocytoma patients relate to catecholamine concentrations of physiological stress of physicians and control patients undergoing adrenalectomy because of hormone inactive tumours. We measured catecholamine concentrations, heart rate and blood pressure in patients with phaeochromocytoma, incidentaloma, a surgeon and an anaesthetist. Methods: After approval of the local ethics committee, we measured metanephrine and normetanephrine plasma concentrations in 8 patients with phaeochromocytoma, 6 control patients with incidentaloma, one surgeon and one anaesthetist at rest, after incision, after 20 and 40 minutes of surgery, and in recovery. Moreover, blood pressure and heart rate were obtained. Results: Intraoperatively significant increases of blood pressure, metanephrine and normetanephrine were found in patients and surgeon. Significant increase of normetanephrine was also found in control patients. But catecholamine concentrations in patients with phaeochromocytoma were 18 to 42 times higher than in control patients and physicians. Heart rate analysis showed no significant results. Conclusion: During phaeochromocytoma resections significant increases in catecholamine concentration and blood pressure can be found in patients and physicians. The excessive increase of catecholamine concentrations in phaeochromocytoma patients, was not always reflected by a corresponding blood pressure increase. Interestingly, although catecholamine concentrations in phaeochromocytoma patients almost normalize directly after surgery, their blood pressure remains stable without the need for pharmacological support.
Development of the L-type CaV / BK Complex Simulator (I): electrophysiological interaction

Complexes formed by voltage-activated calcium channels (CaV) and high-conductance potassium channels activated by Ca2+ (BK) have been studied in smooth muscle, secretory cells and in synaptic terminals, where they regulate muscle contraction, secretory activity, and neurotransmission. However, the complex formed by L- type CaV channels and BK in the soma has been poorly treated. Based on immunostaining studies showing the coexistence of these channels in the neuron soma, their possible interaction was theoretically studied. Two simulators based on the Hodgkin and Huxley formalism were developed to perform virtual experiments on current and voltage clamp. The mathematical models were implemented in Visual Basic® 6.0 and were solved numerically. The results indicate that the BK channels were activated with internal Ca2+ at mM concentrations. The BK channels follow the kinetics of L-type CaVs. The interaction of L-type CaV – BK complex in the soma produced a decrease in neuronal excitability.
Determinants of Facebook use among students and its impact on collaborative learning

The purpose of this study is to investigate the determinants of Facebook use among university students in Jordanian universities, and its impact on collaborative learning. The study compares Facebook use between students of social sciences disciplines and students of sciences disciplines. The study used a quantitative research approach. The research instrument used is a questionnaire. The results of the study showed that the relationship between Facebook use and collaborative learning is above average, which means that the more time spent on Facebook, the better academic performance students achieve through collaborative learning. Additionally, the study revealed that Facebook use was posited to affect collaborative learning, though the level of effect varies between social sciences and science disciplines. The study proposes a model that describes the relation between collaborative learning and Facebook use, which bridges a gap in the Arabic context that lacks models showing this type of relationship.
Energy-Dispersive X-ray Spectroscopic Investigation of Failed Dental Implants Associated with Odontogenic Maxillary Sinusitis

The failed dental implant associated with maxillary sinusitis is a multifactorial phenomenon and should be investigated thoroughly. The inflammatory process induced by accumulated biofilm and wear debris may increase mucous secretion and mucous thickening, which finally may lead to severe complications such as maxillary sinusitis. The inflammatory cytokines might compromise the long-term osseointegration of the related implant. In this study, implants retrieved from three patients who experienced implant failure relating to maxillary sinusitis were investigated using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy. SEM analysis of the implant apical region revealed a less-compact bone structure, indicating the high bone turnover due to an inflammatory process. The ratio of calcium (Ca) and phosphorus (P) was negligible in all specimens. Detection of fluorine (F), sodium (Na), silicon (Si), gold (Au), aluminum (Al), and magnesium (Mg) confirmed the contamination. The selected cases presented different biological aspects that might play the central role in the failed dental implants associated with maxillary sinusitis: the contamination of potentially toxic elements, microorganism infection, and long perforation of implant apex into the sinus. Each of the above phenomena needs to be confirmed with further clinical study with a larger number of failed implants and accompanying tissue samples.
Value of total lesion glycolysis and cell-of-origin subtypes for prognostic stratification of diffuse large B-cell lymphoma patients.

Background This study aimed to explore the added prognostic value of baseline metabolic volumetric parameters and cell of origin subtypes to the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) in nodal diffuse large B-cell lymphoma (DLBCL) patients. Methods A total of 184 consecutive de novo nodal DLBCL patients who underwent baseline positron emission tomography/computed tomography (PET/CT) were included in this study. Kaplan-Meier estimates were generated to evaluate the clinical, biological, and PET/CT parameters' prognostic value. The Cox proportional hazards model was performed to examine the potential independent predictors for progression-free survival (PFS) and overall survival (OS). Results With a median follow-up of 35 months, the 3-year PFS and OS were 65.2% and 73.0%, respectively. In univariate analysis, total lesion glycolysis (TLG), cell-of-origin subtypes, and NCCN-IPI were both PFS and OS predictors. High TLG (≥1,852), non-germinal center B (non-GCB), as well as high NCCN-IPI (≥4), were shown to be independently significantly associated with inferior PFS and OS after multivariate analysis. Based on the number of risk factors (high TLG, non-GCB, and high NCCN-IPI), a revised risk model was designed, and the participants were divided into four risk groups with very different outcomes, in which the PFS rates were 89.7%, 66.2%, 51.7%, and 26.7% (χ2=30.179, P<0.001), and OS rates were 93.1%, 73.8%, 56.7%, and 43.3%, respectively (χ2=23.649, P<0.001), respectively. Compared with the NCCN-IPI alone, the revised risk model showed a stronger ability to reveal further discrimination among subgroups, especially for participants with very unfavorable survival outcomes (PFS: χ2=9.963, P=0.002; OS: χ2=4.166, P=0.041, respectively). Conclusions The TLG, cell-of-origin subtypes, and NCCN-IPI are independent prognostic survival factors in DLBCL patients. Moreover, the revised risk model composed of the number of risk factors (high TLG, non-GCB, and high NCCN-IPI) can stratify patients better than the NCCN-IPI, especially for patients at high risk, which suggests its potential integration into decision making for personalized medicine.
Factors Affecting The Management Of Income

This research aims to obtain empirical evidence about the effect of institutional ownership, managerial ownership, board of commissioner frequency meeting, audit committee frequency meeting, firm size, leverage, audit quality and independent commissioner to earning management. The company used this research is manufacturing company listed in Indonesia Stock Exchange during 2017-2019. There are 37 companies and 111 amounts of data that the meet criteria using purposive sampling method. The model of research used multiple regression analysis. The result shows that leverage influence earning management. Other independent variables institusional ownership, managerial ownership, board of commissioner frequency meeting, audit committee frequency meeting, firm size, audit quality and independent commissioner have no effect to earning management.
Thermodiffractometry and crystal structures of the hexagonal-tungsten-bronze-related K3Al3F12⋅nH2O (n=2,1)

K3Al3F12⋅nH2O (n=2,1) are the successive products of the thermal decomposition of K(H3O)2AlF6. Both structures are orthorhombic, built up from disconnected hexagonal-tungsten-bronze (HTB)-related layers, with K+ cations and H2O molecules inserted between. For n=2, there are two disconnected layers along a presenting different octahedra tilting [a=13.5135(2) Å, b=7.0433(1) Å, c=12.2252(2) Å, V=1163.60(3) Å3, Z=4, space group Pnma], whereas for n=1, the stacking is reduced to only one HTB layer along c [a=7.0523(5) Å, b=12.1005(9) Å, c=6.7057(5) Å, V=572.24(7) Å3 (at 170 °C), Z=2, space group Pmmn] after the departure of one water molecule. The thermodiffractometry ends in the α-KAlF4 form.
Anchorage methods and treatment outcomes in the treatment of bimaxillary protrusion: a systematic review and meta-analysis

ABSTRACT Aim This systematic review aimed to identify the most effective anchorage methods producing better skeletal, dental, aesthetic and patient experience outcomes in the treatment of bimaxillary protrusion. Methods Electronic databases (Pubmed, Medline, Scopus, and Cochrane library) were searched without language restrictions. Unpublished studies were searched for on clinicaltrials.gov. Search terms included bimaxillary proclination, bimaxillary dentoalveolar protrusion, biprotrusion, bimaxillary prognathism, bimaxillary protrusion, and bidental. Treatment studies on patients with bimaxillary protrusion were included. Relevant articles were assessed for quality according to Cochrane guidelines and the data extracted for statistical analysis. Using predefined forms two authors assessed eligibility for inclusion in the study and any disagreement was discussed. Cochrane Risk of Bias tool was used for quality assessment and GRADE was used to assess the quality of the evidence. Results Four studies met the inclusion criteria, while 32 were excluded based on study design and/or no outcome of interest reported. Only three studies were included in the random-effects meta-analysis. There was some evidence to suggest that the use of TADs resulted in less anchorage loss than traditional anchorage techniques (mean difference 2.38 mm; 95% CI, −3.89 to −0.88; P = 0.002). There was a significant difference in treatment duration with use of TADs (mean difference 0.92 months; 95% CI −1.64 to- 0.21; P = 0.01). Conclusion There is very low-quality evidence to suggest TADs provide better anchorage and shorter treatment duration in the orthodontic treatment of bimaxillary protrusion.
Nonequilibrium Entropy Conservation and the Transport Equations of Mass, Momentum, and Energy

Nonequilibrium statistical mechanics or molecular theory has put the transport equations of mass, momentum and energy on a firm or rigorous theoretical foundation that has played a critical role in their use and applications. Here, it is shown that those methods can be extended to nonequilibrium entropy conservation. As already known, the “closure” of the transport equations leads to the theory underlying the phenomenological laws, including Fick’s Law of Diffusion, Newton’s Law of Viscosity, and Fourier’s Law of Heat. In the case of entropy, closure leads to the relationship of entropy flux to heat as well as the Second Law or the necessity of positive entropy generation. It is further demonstrated how the complete set of transport equations, including entropy, can be simplified under physically restrictive assumptions, such as reversible flows and local equilibrium flows. This analysis, in general, yields a complete, rigorous set of transport equations for use in applications. Finally, it is also shown how this basis set of transport equations can be transformed to a new set of nonequilibrium thermodynamic functions, such as the nonequilibrium Gibbs’ transport equation derived here, which may have additional practical utility.
Geophysical Well Logging in Order to Reduce Operating Costs in Mineral Exploration

The geophysical well logging is the practice of making a detailed record of the geological formations penetrated by a well. The record can be based on visual inspection of samples brought to the surface (geological records) or physical measurements made by instruments lowered into the hole (geophysical records). Some types of logs can be made during any phase of a well’s history: drilling, completion, production, or abandonment. The logs are carried out in drilled holes for the exploration of oil and gas, underground, mineral, and geothermal water, in addition to part of environmental and geotechnical studies. In the case of mineral exploration, the main interest in using well logs is to seek on compositional and textural variations caused by changes in moisture and hardness of the rocks. Thus, the technic is satisfactory to detect the presence of clay and hydrated bodies, as well as the transition between friable and compact minerals. Therefore, the results open possibilities to changes exploratory drilling meshes with partial replacement of core sampling by rotary percussive boreholes. This allows to do a mineral exploration with lower costs using a faster and cheaper technique, but always using well logs to support the geological interpretation in subsurface.
Liposomes as carrier vehicles for functional compounds in food sector

ABSTRACT Liposomes are attractive encapsulation systems that provide enhanced stability of encapsulated materials against a range of environmental, enzymatic, and chemical stresses, including the presence of enzymes or reactive chemicals, and exposure to extreme pH, temperature, and ionic strength changes. Liposomes have been widely used in the pharmaceutical and food industries because of their biocompatibility, biodegradability, absence of toxicity, small size, and ability to carry a wide variety of bioactive compounds due to the amphiphilicity of the phospholipid encapsulating material. In the food industry, liposomes have recently been used to deliver different functional compounds in food systems. In this paper, the food application of liposomes and nanoliposomes as emerging carrier vehicles of vitamins, enzymes, food antimicrobials, essential oils, and polyphenols is discussed in detail.