Miracle-dz/UniFAR-FTUs huggingface dataset:
Human Chorionic Gonadotrophin (hCG) Trigger-Mediated Ovulation Induction in Infertility Management in South Indian Women Undergoing IVF/ICSI Regimens: A Pilot Sexual Medicine Study with Public Health Perspective

Introduction: Infertility is a global public health problem; cost-effective patient-friendly treatment modalities along with psychosexual intervention strategies are essential for infertility control/prevention/management among ethnically disparate populations. Objectives: This study aimed to assess differential in vitro fertilization (IVF) success trends among infertile women of South Indian ethnicity. Materials and Methods: Prospective, observational study designed in a hospital-based setting with active enrollment of infertile women undergoing IVF/intracytoplasmic sperm injection (ICSI) at Indira IVF Center, Chennai, Tamil Nadu, India (April-September 2019); inclusion criteria: age >35 years, South Indian ethnicity, married >1 year, absence of full-term clinical pregnancy, endometrial thickness <6 mm/thin endometrium; exclusion criteria: prior ≥2 IVF failures, fibroids/adenomyosis/cervical cancer/endometriosis. IVF success was determined by evaluating total frozen embryos transferred/month, average oocyte yield/donor, oocyte quality, M-II oocytes, biochemical/clinical pregnancy (beta-human chorionic gonadotropin positivity/fetal cardiac activity). Mycobacterium tuberculosis positivity was assessed by GeneXpert polymerase chain reaction-based technology, and psychosexual intervention-incorporated marital relationship counseling sessions/therapy, referrals for psychiatric assessments (cognitive impairment/schizophrenia/depression). Written informed consent of participants was taken and study was approved by Institutional Review Board. Results: Mean age and endometrial thickness of study participants were 33.3 years (SD ±1.9) and 8.7 mm (SD ±0.5), respectively; average Body Mass Index (BMI) and anti-müllerian hormone (AMH) levels were 28.4 kg/m2 and 4.7 ng/mL, respectively. Embryos transferred/month: 7 in April/13 in May/24 in June/36 in July/24 in August/30 in September, and pregnancies: 4/8/17/26/20/22 for the months of April, May, June, July, August, and September 2019, respectively. Subgroup stratification demonstrated M-II vs total oocytes retrieved were 76%, 73%, 60%, 71%, 77%, and 77%. Overall IVF success rates were 57% in April/62% in May/71% in June/72% in July/83% in August/73% in September; frozen embryo transfer success was 0 in April-May/67% in June/73% in July/89% in August/100% in September 2019. English/Tamil-speaking infertile women self-reported treatment-related satisfaction rates of 80% to 100%. Conclusion: M-II oocytes’ yield, sociodemographics of infertile women, and increasing age/aberrant AMH/BMI profiles/endometrial receptivity/diminished ovarian reserve are promising predictors of IVF/ICSI success in genetically distinct patient population subset(s). Future multicentric gene epidemiology studies with larger sample size and precision-based psychiatric assessments/interventions are warranted for development of predictive biomarkers in infertility management.
From “Networked Publics” to “Refracted Publics”: A Companion Framework for Researching “Below the Radar” Studies

Reflecting on a decade (2009–2020) of research on influencer cultures in Singapore, the Asia Pacific, and beyond, this article considers the potential of “below the radar” studies for understanding the fast evolving and growing potentials of subversive, risky, and hidden practices on social media. The article updates technology and social media scholar danah boyd’s foundational work on “networked publics” to offer the framework of “refracted publics. ” While “networked publics” arose from media and communication studies of social network sites during the decade of the 2000s, focused on platforms, infrastructure, and affordances, “refracted publics” is birthed from anthropological and sociological studies of internet user cultures during the decade of the 2010s, focused on agentic and circumventive adaptations of what platforms offer them. “Refracted publics” are a product of the landscape of platform data leaks, political protests, fake news, and (most recently) COVID-19, and are creative vernacular strategies to accommodate for perpetual content saturation, hyper-competitive attention economies, gamified and datafied metric cultures, and information distrust. The key conditions (transience, discoverability, decodability, and silosociality) and dynamics (impactful audiences, weaponized contexts, and alternating publics and privates) of “refracted publics” allow cultures, communities, and contents to avoid being registered on a radar, register in misplaced pockets while appearing on the radar, or register on the radar but parsed as something else altogether. They are the strategies of private groups, locked platforms, or ephemeral contents that will continue to thrive alongside the internet for decades to come.
ZnO films grown by atomic layer deposition for organic electronics

In this review, we analyze the properties of zinc oxide (ZnO) films grown by atomic layer deposition (ALD) crucial for organic electronics applications. We show the examples of such applications in hybrid organic-ZnO p–n junctions as well as in devices where conductive ZnO- and aluminum-doped ZnO films are used as transparent electrodes. Additionally, the relevant issues like energy-gap engineering in ZnO:Al films alloyed with magnesium or the long time stability of organic devices with ZnO passivation layers will be considered.
Development of a pharmacist-led internal medicine outpatient consult service

Background Pharmacists can improve the outcomes of patients with various medical conditions, including heart failure, hypertension, diabetes, dyslipidemia and tobacco use, across the spectrum of care. Previous studies have evaluated various pharmacist interventions, most commonly implemented within community pharmacies or ambulatory clinics, ranging from provision of education and adherence aids to independent prescribing with an expanded scope of practice. Furthermore, reports in the Canadian Pharmacists Journal have described the successful implementation of dedicated consultation services to deliver high-quality pharmacist-led interventions in primary care and geriatric tertiary care in the outpatient setting. The objective of this study was to describe the first 12 months of a pharmacist-led internal medicine outpatient consult service and characterize its implementation, patient population and interventions made by pharmacists.
Variations in vegetation CUE with climate change and human activity during growing seasons in the Western Sichuan Plateau, China

ABSTRACT Carbon use efficiency (CUE) of vegetation in Western Sichuan Plateau (WSP) can influence ecological safety and economic development in the Sichuan Basin and Yangtze River Basin in addition to its importance in determining local ecological environment and development of animal husbandry. Temporal-spatial variations of vegetation CUE as well as its responses to climate changes were investigated through trend analysis and grey relational analysis (GRA) by combining data from meteorological stations, vegetation types and elevation data from WSP. Moreover, the influences of human activities on vegetation CUE were analysed. The results showed that the variation trend of CUE in WSP was unclear, and the variation rate was between −0.11 and 0.10 (per decade) during the growing seasons from 2001 to 2018. Among the climate factors, sunshine duration influenced vegetation CUE mostly, followed by precipitation and air temperature successively. The lagged time of response of vegetation CUE to precipitation was not significant, but to air temperature and sunshine duration was 1–2 months. Human activities have only a slight influence on vegetation CUE in WSP.
Enhancing pomegranate (Punica granatum L.) plant health through the intervention of a Streptomyces consortium

ABSTRACT Soil samples collected from different fruit orchards of Karnataka were used for isolation of Streptomyces spp. and all the isolates were screened for their plant growth-promoting (PGP) traits including phytohormones production viz. indole-3-acetic acid (IAA) and gibberellic acid (GA3), nutrient (phosphate and zinc) solubilisation, siderophore production, enzyme activities (cellulase, tannase and xylanase) and antagonistic potential against soil borne fungal pathogens. Based on PGP traits as well as compatibilities, the following three Streptomyces spp. ‘S. avermitillis PAN Act2 (NAIMCC-B-01412), S. cinnamonesis PAN Act3 (NAIMCC-B-01413) and S. canus PAN Act5 (NAIMCC-B-01342)’ were selected for Streptomyces consortium (SMC) preparation using lignite as carrier material. Out of three isolates, S. canus registered significantly higher IAA and GA3 production compared to other isolates. All three isolates had the potential to suppress the fungal phytopathogens viz. Cerotocystis fimbriata, Fusarium oxysporum, Macrophomina sp. and Sclerotium sp. , with the levels of suppression ranging from 58.0% to 85.0%. The carrier-based SMC was subsequently evaluated in pomegranate to recover the plants from wilt like symptoms under field conditions. From this study, it was found that application of 50 gm of the SMC per plant through soil drenching at regular intervals (once every 2 months) had a significant impact on the recovery of the plant from wilt like symptoms after eight months. The present study is an addition to the growing knowledge on the utility of Streptomyces in fruit production.
Large cryptocurrency-portfolios: efficient sorting with leverage constraints

ABSTRACT Using daily data of the 100 largest cryptocurrencies, we construct the efficient sorting portfolios and the quantile-based sorting portfolios based on ten factors. We find two price factors that can well predict cryptocurrency returns. The efficient sorting portfolios outperform the traditional quantile-based portfolios and the naive portfolios. The outperformance is largely due to the use of DCC-NL estimator, which captures the dynamic of covariance matrix and meanwhile addresses the curse of dimensionality. In addition, leverage constraints are important for cryptocurrency portfolios to control their risks.
Discriminating crops/weeds in an upland rice field from UAV images with the SLIC-RF algorithm

ABSTRACT In this study, we propose a method for discriminating crops/weeds in upland rice fields using a commercial unmanned aerial vehicles (UAVs) and red-green-blue (RGB) cameras with the simple linear iterative clustering (SLIC) algorithm and random forest (RF) classifier. In the SLIC-RF algorithm, we evaluated different combinations of input features: three color spaces (RGB, hue-saturation-brightness [HSV], CIE-L*a*b), canopy height model (CHM), spatial texture (Texture) and four vegetation indices (VIs) (excess green [ExG], excess red [ExR], green-red vegetation index [GRVI] and color index of vegetation extraction [CIVE]). Among the color spaces, the HSV-based SLIC-RF model showed the best performance with the highest out-of-bag (OOB) accuracy (0.904). The classification accuracy was improved by the combination of HSV with CHM, Texture, ExG, or CIVE. The highest OOB accuracy (0.915) was obtained from the HSV+Texture combination. The greatest errors from the confusion matrix occurred in the classification between crops and weeds, while soil could be classified with a very high accuracy. These results suggest that with the SLIC-RF algorithm developed in this study, rice and weeds can be discriminated by consumer-grade UAV images with acceptable accuracy to meet the needs of site-specific weed management (SSWM) even in the early growth stages of small rice plants.
Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes

Objective The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human leucocyte antigen (HLA) genetic variants associated with SSc susceptibility and its main clinical and serological subtypes. Methods 9095 patients with SSc and 17 584 controls genome-wide genotyped were used to impute and test single-nucleotide polymorphisms (SNPs) across the MHC, classical HLA alleles and their composite amino acid residues. Additionally, patients were stratified according to their clinical and serological status, namely, limited cutaneous systemic sclerosis (lcSSc), diffuse cutaneous systemic sclerosis (dcSSc), anticentromere (ACA), antitopoisomerase (ATA) and anti-RNApolIII autoantibodies (ARA). Results Sequential conditional analyses showed nine SNPs, nine classical alleles and seven amino acids that modelled the observed associations with SSc. This confirmed previously reported associations with HLA-DRB1*11:04 and HLA-DPB1*13:01, and revealed a novel association of HLA-B*08:01. Stratified analyses showed specific associations of HLA-DQA1*02:01 with lcSSc, and an exclusive association of HLA-DQA1*05:01 with dcSSc. Similarly, private associations were detected in HLA-DRB1*08:01 and confirmed the previously reported association of HLA-DRB1*07:01 with ACA-positive patients, as opposed to the HLA-DPA1*02:01 and HLA-DQB1*03:01 alleles associated with ATA presentation. Conclusions This study confirms the contribution of HLA class II and reveals a novel association of HLA class I with SSc, suggesting novel pathways of disease pathogenesis. Furthermore, we describe specific HLA associations with SSc clinical and serological subtypes that could serve as biomarkers of disease severity and progression.
Low-energy sweeteners and body weight: a citation network analysis

Objective Reviews on the relationship of low-energy sweeteners (LES) with body weight (BW) have reached widely differing conclusions. To assess possible citation bias, citation analysis was used to quantify the relevant characteristics of cited articles, and explore citation patterns in relation to review conclusions. Design A systematic search identified reviews published from January 2010 to March 2020. Different characteristics (for example, type of review or research, journal impact factor, conclusions) were extracted from the reviews and cited articles. Logistic regression was used to estimate likelihood of articles with particular characteristics being cited in reviews. A qualitative network analysis linked reviews sub-grouped by conclusions with the types of articles they cited. Main outcome measures (OR; 95% CI) for likelihood that articles with particular characteristics were cited as evidence in reviews. Results From 33 reviews identified, 183 different articles were cited (including other reviews). Narrative reviews were 62% less likely to be cited than systematic reviews with meta-analysis (OR 0.38; 0.16 to 0.86; p=0.03). Likelihood of being cited was higher for evidence on children than adults (OR 2.27; 1.59 to 3.25; p<0.0001), and with increased journal impact factor (OR 1.15; 1.00 to 1.31; p=0.04). No other factors were statistically significant in the main analysis, and few factors were significant in subgroup analyses. Network analysis showed that reviews concluding a beneficial relationship of LES with BW cited mainly randomised controlled trials, whereas reviews concluding an adverse relationship cited mainly observational studies. Conclusions Overall reference to the available evidence across reviews appears largely arbitrary, making citation bias likely. Differences in the conclusions of individual reviews map onto different types of evidence cited. Overall, inconsistent and selective use of the available evidence may account for the diversity of conclusions in reviews on LES and BW. Trial registration number Prior to data analysis, the protocol was registered with the Open Science Framework (https://osf.io/9ghws).
Molecular electrostatic properties of ions in an ionic liquid

We have analysed the electronic wave functions from an ab initio simulation of the ionic liquid (room temperature molten salt) dimethyl imidazolium chloride ([dmim][Cl] or [C1mim][Cl]) using localized Wannier orbitals. This allows us to assign electron density to individual ions. The probability distributions of the ionic dipole moments for an isolated ion and for ions in solution are compared. The liquid environment is found to polarize the cation by about 0.7 D and to increase the amplitude of the fluctuations in the dipole moments of both cation and anion. The relative changes in nuclear and electronic contributions are shown. The implications for classical force fields are discussed.
ENZYMATIC REACTIONS PREDICTION OF SOLVENT WATER CONTENT FOR OPTIMUM WATER ACTIVITY IN NON-CONVENTIONAL MEDIA:

Most enzymes provide their optimum performance at a given water activity (aw), which is generally solvent independent. For a given organic liquid solvent at a specific temperature or for a supercritical solvent at a specific temperature and pressure this corresponds to a water concentration in which water has the desired activity. We present here a methodology for predicting this water concentration thus reducing substantially the amount of experimental work needed to find the optimum solvent with respect to equilibrium conversion. If the enzyme optimum water activity is known, the methodology predicts the required water content in the solvent to achieve this a, value. If, in addition, the enzyme water activity curve is available, this methodology provides the total water that must be added to the system (enzyme plus solvent) so that a specific water activity can be obtained. The same methodology can also be applied to predict the effect of the total water content of the system (initial or initial plus produced) on the water activity values. It is shown that: (a) for esterification reactions taking place in hydrophobic organic solvents, the produced water can lead to a substantial change in water activity, but not for less hydrophobic solvents; (b) introduction of dry CO2 into a system, pre-equilibrated to a certain water activity at atmospheric pressure, can lead to a substantial decrease in the water activity especially at temperatures just above the critical one of the solvent and pressures larger than that.
The influence of soil pH on denitrification: progress towards the understanding of this interaction over the last 50 years

Results from the pioneering research on the interactions between pH and denitrification in soil from the 1950s to the present are reviewed, the changing perceptions of this complex relationship are discussed, and the current status of the subject is assessed. Facets of this relationship that are analysed in detail include the direct or indirect influence of pH on overall denitrification rates in soils, changes in the composition of gaseous products that depend on pH, methods for measuring the process, the concept of an optimum pH for denitrification, and the adaptation of microbial denitrifying communities to acidic environments. The main conclusions to be drawn are as follows. Total gaseous emissions to the atmosphere (N2O, NO and N2) have repeatedly been shown to be less in acidic than in neutral or slightly alkaline soils. This may be attributable to smaller amounts of organic carbon and mineral nitrogen available to the denitrifying population under acid conditions rather than a direct effect of low pH on denitrification enzymes. Numerous laboratory and field studies have demonstrated that the ratio N2O:N2 is increased when the pH of soils is reduced. The relation between soil pH and potential denitrification as determined by various incubation methods remains unclear, results being influenced both by original conditions in soil samples and by unknown changes during incubation. The concept of an optimum pH for denitrification has been frequently proposed, but such a term has little or no meaning without reference to specific attributes of the process.
Relationship between resist performance and reaction order in a chemically amplified resist system

The threshold cross‐link density model describes the effect of cross‐link density (Θ) on image formation and the relationship of the cross‐link density to acid concentration in the resist. This method was used to determine experimentally the reaction order of acid in the cross‐linking reaction of negative acid catalyzed resists. The order of the cross‐linking reaction in acid effectively modulates the aerial image of the resist by transforming the initial acid concentration defined by the aerial image by a power equal to the reaction order of the acid. The reaction order of the acid catalyzed cross‐linking reaction is also determined via the measurement of bulk resist properties. Determining the reaction order by bulk methods generates a quantity that is independent of the effects of acid diffusion in the resist and is similar to that obtained by the threshold cross‐link density model. Also described is the effect acid diffusion will have on mitigating the enhancement of the image obtained with large reac.
THE CYCLODEXTRINS: A REVIEW

Cyclodextrins are useful functional excipients that have enjoyed widespread attention and use. The basis for this popularity from a pharmaceutical standpoint is the ability of these materials to interact with poorly water soluble drugs and drug candidates resulting in an increase in their apparent water solubility. The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The purp review is to discuss and summarize some of the findings and applications of cyclodextrin (CD) and their derivatives in different areas of drug delivery. This article also highlights the chemistry, molecular structure, methods of complexation an d focuses on its use for parenteral, oral, ophthalmic and nasal drug delivery. Abstract Cyclodextrins are useful functional excipients that have enjoyed widespread attention and use. The basis for this popularity from a pharmaceutical standpoint is the ability of these materials to interact with poorly water soluble drugs and drug candidates resulting in an increase in their apparent water solubility. The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The purp review is to discuss and summarize some of the findings and applications of cyclodextrin (CD) and their derivatives in different areas of drug delivery. This article also highlights the chemistry, molecular structure, methods of complexation an d focuses on its use for parenteral, oral, ophthalmic and nasal drug delivery.
alpha omicro Crystallography of the transition in shock-loaded zirconium

The orientation relations (ORs) between the alpha (hcp) and the omicro (three-atom hexagonal) structures have been determined for Zr, in which alpha transformed to omicro under shock loading. The ORs obtained are found to belong to the variant I OR given by Usikov and Zilbershtein in 1973 for statically compressed samples and also consist of an OR that is the same as that reported by Song and Gray in 1995 in recent dynamic experiments on Zr. The latter OR is shown to be a subset of the former. These observations show that the same type of mechanism of transformation is operative under both static pressure and shock compression. The crystallography of the transition is discussed in terms of the required strains.