Miracle-dz/UniFAR-FTUs huggingface dataset:
Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors

Abstract Chk1 is the major mediator of cell-cycle checkpoints in response to various forms of genotoxic stress. Although it was previously speculated that checkpoint abrogation due to Chk1 inhibition may potentiate the efficacy of DNA-damaging agents through induction of mitotic catastrophe, there has not been direct evidence proving this process. Here, through both molecular marker and morphological analysis, we directly demonstrate that specific downregulation of Chk1 expression by Chk1 siRNA potentiates the cytotoxicities of topoisomerase inhibitors through the induction of premature chromosomal condensation and mitotic catastrophe. More importantly, we discovered that the cellular cyclin B1 level is the major determinant of the potentiation. We show that downregulation of cyclin B1 leads to impairment of the induction of mitotic catastrophe and correspondingly a reduction of the potentiation ability of either Chk1 siRNA or a small molecule Chk1 inhibitor. More significantly, we have extended the study by examining a panel of 10 cancer cell-lines with different tissue origins for their endogenous levels of cyclin B1 and the ability of a Chk1 inhibitor to sensitize the cells to DNA-damaging agents. The cellular levels of cyclin B1 positively correlate with the degrees of potentiation achieved. Of additional interest, we observed that the various colon cancer cell lines in general appear to express higher levels of cyclin B1 and also display higher sensitivity to Chk1 inhibitors, implying that Chk1 inhibitor may be more efficacious in treating colon cancers. In summary, we propose that cyclin B1 is a biomarker predictive of the efficacy of Chk1 inhibitors across different types of cancers. Unlike previously established efficacy-predictive biomarkers that are usually the direct targets of the therapeutic agents, cyclin B1 represents a non-drug-target biomarker that is based on the mechanism of action of the target inhibitor. This finding may be potentially very useful for the stratification of patients for Chk1 inhibitor clinical trials and hence, maximize its chance of success.
Constructing Digital Democracies: Facebook, Arendt, and the Politics of Design

Deliberative democracy requires both equality and difference, with structures that organize a cohesive public while still accommodating the unique perspectives of each participant. While institutions like laws and norms can help to provide this balance, the built environment also plays a role supporting democratic politics—both on- and off-line. In this article, I use the work of Hannah Arendt to articulate two characteristics the built environment needs to support democratic politics: it must (1) serves as a common world, drawing users together and emphasizing their common interests and must also (2) preserve spaces of appearance, accommodating diverse perspectives and inviting disagreement. I, then, turn to the example of Facebook to show how these characteristics can be used as criteria for evaluating how well a particular digital platform supports democratic politics and providing alternative mechanisms these sites might use to fulfill their role as a public realm.
SOME NEW RESULTS ON NON-NEGATIVE MAJORITY TOTAL DOMINATION IN GRAPHS

Abstract: For a simple graphG = (V; E), a two valued function h: V → {−1, 1} is called a non-negative majority total dominating function if the sum of its function values over at least half the open neighborhoods is at least zero. A non-negative majority total domination number of a graph G is the minimum value of ∑ h(v) v∈V(G) over all non-negative majority total dominating functions f of G and it is denoted by γmaj nt (G).
Genetic Variation and Divergence in the Genus Carcinus (Crustacea, Decapoda)

The extent of genetic differentiation of the decapod crustaceans Carcinus maenas (L.) and C. aestuarii Nardo was studied in nine nearshore locations comprising various European marine and brackish-water habitats, (Norway, Germany, France, Spain, Italy and Yugoslavia), using starch gel electrophoresis. The heterozygosity for all 19 allozyme loci was 0.026–0.016 (C. maenas) and 0.011–0.003 (C. aestuarii); one locus (Pgm) was the most polymorphic. The populations had rather low levels of genetic variability, comparable to those found in other decapods. In general, a light clinal variation in allele frequencies was discovered at the Pgm locus of C. maenas as latitude decreased. Because of similar morphologies and a closed genetic relationship (I = 0.89), the two forms should be considered subspecies. Therefore, the designation of the Atlantic subspecies C. maenas maenas is proposed, and the term of the Mediterranean subspecies C. maenas aestuarii is recommended.
Properties of active rectifier with LCL filter in the selection process of the weighting factors in finite control set-MPC

One of the main problems of multivariable cost functions in model predictive control is the choice of weighting factors. Two finite control set model predictive control algorithms, applied to the three-phase active rectifier with an LCL filter, are described in the paper. The investigated algorithms, i.e. PCicuc and PCigicuc, implement multivariable approaches applying line (grid) current, capacitor voltage and converter current. The main problem dealt with in the paper is the choice of optimum values of the cost function weighting factors. The values of the factors calculated using the method proposed in the paper are very close to the values represented by the lowest THDi of the line current. Moreover, simulations verifying the equations used in the prediction of controlled values, i.e. line current, capacitor voltage and converter current, are presented. Both simulation and experimental results are presented to verify effectiveness of the investigated control strategies under change of the load (P = 5 kW and 2.5 kW), during transient states, under unbalanced and balanced line voltage.
Digestão de carboidratos em equinos alimentados com dietas compostas de volumoso ou de volumoso suplementado com concentrado e/ou óleo de soja

Determinaram-se as fracoes dos carboidratos nao fibrosos, hidrolisaveis e rapidamente fermentaveis em diferentes dietas e estimou-se a digestibilidade aparente desses nutrientes em dois ensaios com equinos. No ensaio I, utilizaram-se quatro equinos em delineamento quadrado latino 4x4, que consumiram dietas compostas por: feno de tifton-85; feno de tifton-85 e feno de alfafa; feno de tifton-85, feno de alfafa e concentrado; feno de tifton-85 e concentrado. No ensaio II, utilizaram-se 15 equinos em delineamento inteiramente casualizado, que consumiram dietas com 5, 13 e 21% de extrato etereo, obtidos com a inclusao de diferentes proporcoes de oleo de soja. A inclusao de concentrado nas dietas aumentou a digestibilidade dos carboidratos nao fibrosos e de suas fracoes, sem afetar a digestibilidade da fibra, enquanto, em dietas com 13% de extrato etereo, a digestibilidade das fracoes dos carboidratos fibrosos e a dos nao fibrosos nao foram afetadas. Nas dietas com 21% de extrato etereo, houve reducao na digestibilidade da celulose e dos carboidratos nao fibrosos e suas fracoes hidrolisaveis e rapidamente fermentaveis. A analise dos carboidratos nao fibrosos e uma boa estimativa do valor nutricional dos alimentos, podendo ser incluida na avaliacao da qualidade dos alimentos e dietas dos equinos.
Maize Physiological Responses to Heat Stress and Hormonal Plant Growth Regulators Related to Ethylene Metabolism

Hormonal plant growth regulators (H pGrs) have been evaluated in field grown maize ( mays L.), but never as a tool for prevention or mitigation of heat stress. We analyzed grain yield determination of maize crops exposed to contrasting temperature regimes (nonheated control plots [T C ]; heated plots [T H ]) and the application of HpGrs associated with ethylene metabolism (ethephon [ETH]; MCp [1-MCp]). Heating extended over daytime hours between V 11 and tasseling (VT), and products were sprayed immediately before (V ) and/or during (V 16 ) heating. plants treated with ETH always had reduced height (10–21%) and leaf area (3–10%), but these trends usually had no effect on light interception during treatment period. Biomass production was markedly affected by heating, but a significant interaction effect ( < 0.01) indicated that HpGrs caused (i) no effect among T H plots, and (ii) a decrease (13–19% for ETH and 3.8–9.4% for MCp) among T C plots. The interaction effect computed for grain yield highlighted that ETH had mild negative effects (£ 18%) among T C plots and large positive effects among T H plots (up to 73%), whereas MC p had no effect among the former and mild positive (V 16 ) or negative (V 11 ) effects among the latter. Variations in grain yield were due to variations in kernel numbers ( r 2 ³ 0.92), which were
Back to reality. Il gap tra teoria e prassi negli studi di controllo di gestione: quali prospettive?

Il gap tra teoria e prassi. È stato questo il tema dell’VIII Workshop della rivista Management Control organizzato, lo scorso 14 giugno, dal Dipartimento di Management dell’Università Politecnica delle Marche, con il patrocinio della Società Italiana dei Docenti di Ragioneria e di Economia Aziendale. Un tema che, ormai da diversi anni, ricorre con frequenza negli studi di controllo di gestione e che, negli ultimi tempi, è stato oggetto di un crescente interesse da parte di ricercatori di ogni settore scientifico-disciplinare. Gli studi sul tema hanno conosciuto una profonda evoluzione nel tempo, stimolati dalla diffusa percezione di un sistema universitario lontano dalle esigenze del contesto socio-economico di riferimento e dall’introduzione di sistemi di valutazione della ricerca che mirano a misurare la qualità della produzione scientifica anche, sebbene non prioritariamente, in base al suo impatto sulla società. Di uno scollamento tra teoria e prassi negli studi di controllo di gestione parlavano già Johnson e Kaplan nel lontano 1987 quando, nella loro opera seminale dal titolo “Relevance Lost: the Rise and Fall of Management Accounting”, denunciavano con forza la graduale perdita di rilevanza degli strumenti di management accounting e, al tempo stesso, sostenevano l’esigenza di un profondo ripensamento della ricerca su questi temi. A partire da quel contributo, l’idea dell’esistenza di un gap tra teoria e prassi si è progressivamente diffusa e rafforzata, stimolando una considerevole crescita del numero di contributi focalizzati sulla perdita di rilevanza degli studi di controllo di gestione (Mitchell, 2002; Scapens, 2006; Hopwood, 2008; Baldvinsdottir et al., 2010; Paolini e Quagli, 2013; Tucker e Parker, 2014; Quagli, Avallone e Ramassa, 2016; Gatti, 2018).
Cadmium turnover in minnows (phoxinus phoxinus) preexposed to waterborne cadmium

The radioactive isotope 109Cd was used to study the turnover of Cd in minnows (Phoxinus phoxinus) preexposed to waterborne Cd. Three groups of fish were preexposed to 3 nM Cd for 0, 30 and 91 d before a 24-h 109Cd exposure (3 nM Cd). The effect of preexposure on the turnover of 109Cd in the fish was studied during a 64-d post-tracer exposure period at 3 nM Cd. The major effect of Cd preexposure on the 109Cd turnover was a decreased uptake of 109Cd into the gills. In the gill tissue, the 109Cd was retained by Cd binding ligands mainly in the cytosolic fraction. Preexposure decreased the percentage of 109Cd retained in a cytosolic high-molecular-weight fraction at the end of the tracer exposure. At the same time, an increased percentage of tracer was retained in a low-molecular-weight cytosolic fraction with high 109Cd content (Cd-BP), probably metallothionein (MT). This effect was not caused by an increased MT content in the preexposed fish. The liver, kidney, muscle and bone accumulated 109Cd, while the gills, head and skin eliminated tracer during the 64-d post-tracer exposure period. The 109Cd elimination and accumulation were not altered by the Cd preexposure. A large part of the tracer accumulated in the liver and kidney was detected in the Cd-BP fraction, and the MT content in the organs was not altered by the preexposure.
Effect of Methanol Extract of Unripe Carica papaya Pulp on Lipid Profile and Liver Function of Alloxan-Induced Diabetic Rats

Background: Carica papaya is commonly used in the treatment of various diseases like constipation, piles, hypertension and malaria. The ameliorative effect of Carica papaya on alloxan-induced diabetic rats has been suggested by several studies. Aim: The present study aims to investigate the effect of methanolic extract of unripe Carica papaya pulp on the lipid profile and liver biomarkers of a diabetic rat. Materials and Methods: After acclimatization, thirty-two (32) animals were randomly classified into 8 groups (4 rats per group). The different test (extract) groups received in addition to normal diet ad libitum, dosages of 200, 400, 600 and 1000 mg/kg/day of the Carica papaya extract. The normal and negative control groups received a normal diet, while the positive control was given oral treatment with 6 mg/65 kg/day of glibenclamide as well as the normal diet. After 28 successive days of treatment, all the experimental rats were sacrificed by ocular puncture and the serum used in the evaluation of body lipids, liver function parameters and biochemical indexes. Results: The administration of the unripe Carica papaya extract resulted in a dose-dependent and significant decrease (p<0.05) in serum albumin, aspartate aminotransferase (AST), total protein, and in alanine aminotransferase (ALT) level. There was, however, a significant increase in High-density lipoprotein (HDL) level for 400-1000 mg/kg extract groups. The result also showed a reduced cholesterol level at an extract dose of 1000 mg/kg/day. Conclusion: The ameliorative properties of the unripe pulp of Carica Papayaon biochemical parameters of a diabetic rat, as shown from the result could be indicative that unripe Carica papaya can be valuable in the management of diabetes mellitus and other complications that may arise.
On optimizing scalar self-rebalancing trees

Balanced trees are pervasive and very often found in databases or other systems which are built around querying non-static data. In this paper, we show that trees implemented as a collection of pointers shows bad data locality, poor cache performance and suffer from a lack of parallelism opportunities. We propose an alternative implementation based on arrays. Both implementations appear to be equivalently efficient time-wise. This new layout exposes new parallelism opportunities which can be then exploited by an optimizing polyhedral compiler.
A survey of crystal structures and biological activities of platinum group metal complexes containing N-acylthiourea ligands

Abstract N-Acyl-thioureas are important compounds in the field of organic synthesis and medicinal chemistry. Research interest in these compounds has grown recently because coordination to metal ions enhances their application especially in view of medicinal studies. These thiourea derivatives possess rich coordination chemistry and the coordination behavior of these derivatives alters upon reaction with different metals. Such ligands generally coordinate to Pt(II) and Pd(II) ions in a bidentate S,O manner and often coordinate to Ru(II), Rh(III) and Ir(III) centers through the S donor atom. We isolated some complexes of these ligands by reaction with sodium azide which coordinates to Ru(II), Rh(III), and Ir(III) in a bidentate S,N fashion. The deprotonated thiourea nitrogen atom resulted in the formation of strained 4-membered ring structures around the metal center. Biological application of N-acyl thiourea derivatives and their platinum group metal complexes are further discussed. Studies has shown that these compounds can be used as drugs to treat several human diseases like microbial infections, tuberculosis, carcinomas, malaria, leishmaniasis, urease inhibitors and anti-inflammatory. This review intends to summarize the recent advancement in the chemistry of N-acyl-thioureas and highlight some perspectives in the synthesis, versatile coordination behavior to ruthenium, rhodium, iridium, platinum and palladium, and their metal complexes in biological applications. Graphical Abstract
The status of Garra ghorensis in Jordan: distribution, ecology and threats

Abstract Six sites in Jordan were continuously visited during the year 2002 to study the distribution and the status of the cyprinid fish Garra ghorensis which is endemic to the southern Dead Sea area. Parameters such as temperature, conductivity, salinity, total dissolved solids, dissolved oxygen, pH, and water current speed were used to characterise each site. The population structure for both G. ghorensis and the introduced cichlid Oreochromis aureus in Ain al-Haditha is illustrated. Current threats affecting G. ghorensis are briefly discussed.
Organophosphate Pesticide Exposure and Neurodevelopment in Young Mexican-American Children

Background Organophosphate (OP) pesticides are widely used in agriculture and homes. Animal studies suggest that even moderate doses are neurodevelopmental toxicants, but there are few studies in humans. Objectives We investigated the relationship of prenatal and child OP urinary metabolite levels with children’s neurodevelopment. Methods Participating children were from a longitudinal birth cohort of primarily Latino farm-worker families in California. We measured six nonspecific dialkylphosphate (DAP) metabolites in maternal and child urine as well as metabolites specific to malathion (MDA) and chlorpyrifos (TCPy) in maternal urine. We examined their association with children’s performance at 6 (n = 396), 12 (n = 395), and 24 (n = 372) months of age on the Bayley Scales of Infant Development [Mental Development (MDI) and Psychomotor Development (PDI) Indices] and mother’s report on the Child Behavior Checklist (CBCL) (n = 356). Results Generally, pregnancy DAP levels were negatively associated with MDI, but child measures were positively associated. At 24 months of age, these associations reached statistical significance [per 10-fold increase in prenatal DAPs: β = −3.5 points; 95% confidence interval (CI), −6.6 to −0.5; child DAPs: β = 2.4 points; 95% CI, 0.5 to 4.2]. Neither prenatal nor child DAPs were associated with PDI or CBCL attention problems, but both prenatal and postnatal DAPs were associated with risk of pervasive developmental disorder [per 10-fold increase in prenatal DAPs: odds ratio (OR) = 2.3, p = 0.05; child DAPs OR = 1.7, p = 0.04]. MDA and TCPy were not associated with any outcome. Conclusions We report adverse associations of prenatal DAPs with mental development and pervasive developmental problems at 24 months of age. Results should be interpreted with caution given the observed positive relationship with postnatal DAPs.
Study of building arrangements in the old city corridor of Tanjung Pura

As in other cities in Indonesia, economic development, population growth is one of the causes of the physical changes in the Chinatown shop building on the Sudirman Street corridor in the old city of Tanjung Pura. The building turned into a modern building, which caused the loss of old buildings as a characteristic and identity of Tanjung Pura city as one of the historical cities that distinguishes it from the other cities in Indonesia. To prevent the deterioration of the physical, functional and visual character of this historic region, it is necessary to arrange a building arrangement on Sudirman Street in the old city of Tanjung Pura. The research method used in this study is a qualitative methodology, with indicators based on variables obtained from the foundation to find the visual characteristics of the building structure and the factors that influence the structure of the building. The indicators are arranged based on variables then used as benchmarks in finding data and analyzing.
Investigation of Serum and Wool Levels of Cobalt, Manganese, Selenium and Zinc in Liver-Trematode-Infected Sheep

Bu calismada saglikli ve karaciger trematodu ile enfekte olmus koyunlarda hematolojik ve biyokimyasal kan degerleri ile serum ve yun eser elementlerindeki (kobalt [Co], mangan [Mn], cinko [Zn] ve selenyum [Se]) farkliliklar karsilastirilmistir. Bu amacla 80 bas karaciger trematodlu ve 20 bas da saglikli olmak uzere toplam 100 bas koyun kullanildi. Karaciger trematodlu koyunlarin lokosit (WBC), notrofil (Neu) ve eozinofil (Eo) duzeyleri kontrol grubunun ayni parametrelerinden istatistiki olarak onemli duzeyde yuksek (P<0,01) tespit edilirken, eritrosit (RBC), hematokrit (Hct) ve hemoglobin (Hb) degerleri daha dusuk (P<0,01) bulunmustur. Karaciger trematodlu koyunlarin alanin aminotransferaz (ALT), aspartat aminotransferaz (AST) ve gamma glutamil transpeptidaz (GGT) degerleri saglikli koyunlarin ayni parametrelerine gore sirasiyla P<0,001, P<0,005 ve P<0,001 duzeylerinde yuksek tespit edildi. Karaciger trematodlu koyunlarin serum ve yun Co, Mn, Zn ve Se seviyeleri saglikli koyunlara gore istatistiksel olarak onemli duzeyde dusuk bulunmustur (P<0,01). Karaciger enfeksiyonlarinin iz element konsantrasyonlari uzerindeki etkisinin yun ve serumdaki olcumlerinin benzerlik gosterdigi saptanmistir. Karaciger trematodlu koyunlarin serum ve yun iz elementlerin konsantrasyonundaki dususlerin karacigerdeki patolojik bozukluklarina bagli olarak olusan iz elementlerin biyotransformasyonundaki degisimlerinde kaynaklanabilecegi dusunulmektedir.
The effect of dietary intake of calcium and phosphorus on the absorption and excretion of phosphorus in chimaera-derived sheep

SUMMARY The effect of ratios of calcium to phosphorus in the diet (varying from 0·6 to 3·6) on the absorption and excretion of P was investigated with four sets of 9-month-old chimaera-derived triplets. A pelleted cereal-based diet supplemented to contain 1·5, 3·1 or 6·2 g P/kg D.M. and 3·4 or 5·4 g Ca/kg D.M. was used in a factorial design. The additional Ca in the diet reduced the efficiency of absorption of the P supplements in the diet by 0·18 ± 0·04. The efficiencies of absorption of total P were very similar within but markedly different between (P < 0·001) sets of triplets, the mean values being 0·62, 0·74, 0·82 and 0·84. The fractional absorption of inorganic P alone showed the same ranking and the mean values were 0·47, 0·67, 0·85 and 0·92. These differences between triplets support the view that the individual differences in P metabolism have a genetic basis. The mean absorbability of P in the basic diet (0·77) and in the P supplements (0·73) were similar. The pattern of excretion of absorbed P between the faecal and urinary route of excretion varied between the sets of triplets; as P intake increased, the additional absorbed P was excreted in faeces by one set, in urine by another and in faeces and urine by two sets. The relative importance of the faecal route was dependent upon the fractional absorption of P secreted into the gut.