Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic Association between SORL1 Polymorphisms and Alzheimer’s Disease in a Japanese Population

Background/Aims: It has recently been shown that the neuronal sortilin-related receptor (SORL1) plays an important role in the pathogenesis of Alzheimer’s disease (AD). Methods: To investigate whether variations around the SORL1 gene are associated with AD, 7 single-nucleotide polymorphisms (SNPs) were genotyped using TaqMan® technology with 180 AD patients and 130 age-matched controls. Results: Our results confirmed the strong linkage disequilibrium among the 7 SNPs studied. However, our study failed to detect any association between the SNPs and AD. We could not confirm any synergetic interaction between the SNPs and apolipoprotein E in our AD patients either. Conclusion: Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD.
Computational modelling to optimized parameter's build of a Terahertz photoconductive antenna

El siguiente trabajo presenta la simulacion multifisica de una antena fotoconductora (PCA) con rejillas de contacto plasmonica anadiendo una capa de Nitruro de Silicio (Si3N4) para mejorar las propiedades de absorcion optica de hasta un 90% de la luz incidente, ademas, se incorpora un arreglo de nano estructuras conicas compuestas de Oxido de Zinc (ZnO) que actuan como concentradores opticos sobre la capa del substrato semiconductor de LT - GaAs para aumentar el campo local y de esta manera mitigar las principales desventajas de este tipo de emision THz como lo son la baja eficiencia cuantica y la absorcion optica sobre el substrato.
An investigation on anti-depressant activity of fresh fruit juice of Malus domestica in experimental animal models

Objective: To evaluate the anti-depressant effect of acute and chronic administration of fresh fruit juice of Malus domestica in experimental animal models. Methods: Anti-depressant activity of fresh fruit juice of Malus domestica was investigated in experimental animal models. Two doses 0.5ml and 1ml of FFJMD (oral route) was subjected for the evaluation as acute (1day) and chronic treatment (10days). Imipramine (10mg/kg oral) was used as standard in all the models of animals and parameters estimated includes estimation of biochemical parameter (mono amino oxidase). Results: Both the lower (0.5ml) and higher dose (1ml) of Malus domestica fresh fruit juice showed dose dependent significant decrease in depression. In acute and chronic forced swim test as well as acute tail suspension test, duration of immobility was significantly reduced in the FFJMD 1 ml and 0.5 ml treated group but the effectiveness was found more in FFJMD 1 ml. In hole board test there is increase in activity with FFJMD 0.5 ml and 1 ml treated groups and increase in biochemical parameter such as mono amino oxidase when compared with depressive control. The antidepressant activity of 1 ml was comparable to that of Imipramine 10 mg/kg. Conclusion:The present study suggests that fresh fruit juice of Malus domestica has antidepressant activity in both the doses but more beneficial effect was found in chronic administration at 1 ml. It would be advisable to encourage consumption of Malus domestica extract in patients with depression because of its nutritional and functional properties.
Sattvavajaya Chikitsa (psychotherapy) as a preventive aspect in Akalaja Jara (premature ageing)

The present condition of human health around the globe is far from satisfaction. Man is suffering from the diseases which are caused due to stress either mental or physical and premature ageing (Akalaja Jara) is one of them. There are many theory related to ageing among all of them Free Radical Theory is most acceptable, which answers most of the questions related with Psychological as well as Physical changes during ageing. Stress can be considered as a major factor for Akalaja Jara. Sattvavajaya Chikitsa is a specialized type of treatment influencing the psychological aspect of body. It can be applied in the form of Yogic practices and other mind control techniques. As mind and body are interrelated to each other, these techniques also affect physical health. It is the unique concept of Ayurveda which may be effective in improving quality of life. That is why to deal with stress and to prevent Akalaja Jara, Sattvavajaya (control of mind from unwholesome objects) could be a better approach.
Rule-Based Data-Driven Analytics for Wide-Area Fault Detection Using Synchrophasor Data

Synchrophasor technology, also known as wide-area monitoring system technology, utilizes phasor measurement unit (PMU) to monitor real-time system data, which can provide unique insights into the operation of a power grid. In this paper, a rule-based data-driven analytics method for wide-area fault detection in a power system using synchrophasor data is proposed. As a data-driven approach, this method relies on rules created using PMU measurement data, and does not require knowledge of the power system's topology and model. It can detect fault location (bus and line) and fault type for a particular fault event. Three common types of short circuit faults in a power grid, single-line-to-ground, line-to-line, and three-phase faults, can be identified using the proposed method. Fault thresholds used in rules are determined based on theoretical values and recorded PMU data during fault events in Bonneville power administration (BPA)'s large power grid. The proposed method is validated by comparing with the recorded field data for fault events provided by BPA. It is found that it can effectively detect most faults with a great accuracy. It has been developed into a software program, and can be readily used by utility companies.
14.4mW 10Gbps CMOS limiting amplifier with local DC offset cancellers

A low-power limiting amplifier (LA) with DC offset cancellers (DCOCs) using local feedback loops is presented for D-band wireless transceivers. The number of cascaded stages of amplifiers is set to minimize the gain-bandwidth product (GBW) of each amplifier that has the required bandwidth to realize low power dissipation. The capacitance used in each DCOC is reduced by the local feedback loops. In addition, the area used by the capacitors in each DCOC is reduced by arranging metal-oxide-metal (MOM) capacitors on MOS capacitors. Moreover, a push-pull-type topology using only NMOSs is used as an output buffer to reduce the power dissipation. Furthermore, an inductive peaking technique is used for amplifiers to realize a large bandwidth. The proposed LA has been fabricated by a 40nm CMOS process. It has a differential voltage gain of 45dB, a bandwidth of approximately 6.5GHz, a power dissipation of 14.4mW, and a circuit area of 0.15mm2. It can operate with a data rate of 10Gbps.
Handbook on Obsessive-Compulsive and Related Disorders

Handbook on Obsessive-Compulsive and Related Disorders Edited by K. A. Phillips and D. J. Stein American Psychiatric Association Publishing, 2015, £41.40, pb, 300 pp. ISBN: 9781585624898 This multi-author book examines the disorders categorised in DSM-5 as obsessive-compulsive and related
Measuring environmental orientation in hotels: empirical evidence from Sri Lanka

ABSTRACT The paper presents a quantitative approach to measure environmental orientation in hotels. It proposes a composite indicator, which consists of five individual indicators, namely environmental records, environment policy, environment management systems, involvement in relevant projects/programmes and receipt of environmental awards and certifications. The paper also attempts to empirically assess factors affecting environmental orientation of hotels using primary data collected through a survey of hotels. The paper finds that hotel characteristics play an important role in hotel’s environmental orientation. Customer characteristics and manager characteristics do not show a statistically significant relationship to environmental orientation in hotels.
Typical failure mechanism of LED package

Traditional epoxy filled with quartz sand cannot be used as plastic packaging materials of LED, as it is a kind of optoelectronic device. Its plastic packaging materials must be those with high light transmission rate such as epoxy and silicone. But these packaging materials also have the following weak points: big thermal mismatch coefficient with chip and lead frame, poor air tightness, easy to thermal aging or corrosion aging, etc. These weak points would greatly increase the failure rate of LED devices, because of their high heat exchanging efficiency. As expected, during the process of LED device failure analysis, combining with the analysis method of polymer materials, these weak points are proved to be the fundamental reasons of the failure. The failure mechanism including: the electrochemical corrosion of chip and lead frame caused by moisture permeability, chemical corrosion of lead frame and bonding wire and other metallic materials caused by corrosive gas permeation, the corrosion and aging of encapsulant, etc. According to these failure mechanisms, more specific suggestions are offered to increase LED device quality.
A Novel Indoor Positioning System for Firefighters in Unprepared Scenarios

Situational awareness and indoor positioning of firefighters are types of information of paramount importance to the success of search and rescue operations. GPS units are undependable for use in Indoor Positioning Systems due to their associated margins of error in position and their reliance on satellite communication that can be interrupted inside large structures. There are few other techniques like dead reckoning, Wifi and bluetooth based triangulation, Structure from Motion (SFM) based scene reconstruction for Indoor positioning system. However due to high temperatures, the rapidly changing environment of fires, and low parallax in the thermal images, the above techniques are not suitable for relaying the necessary information in a fire fighting environment that is needed to increase situational awareness in real time. In fire fighting environments, thermal imaging cameras are used due to smoke and low visibility, hence obtaining relative orientation from camera information alone becomes very di cult. We gained a deeper appreciation of the significance of maintaining a sense of relative orientation to a first responders ability to successfully navigate
fMRI in Translation: The Challenges Facing Real-World Applications

Functional neuroimaging has increased our understanding of human brain function tremendously and has become a standard tool in clinical and cognitive neuroscience research. We briefly review its methodological foundations and describe remaining challenges for translational research. The application of neuroimaging results to individual subjects, for example in predicting treatment response or determining the veracity of a statement, is limited by these challenges, in particular by the anatomical and statistical procedures commonly employed. We thus argue for sincere caution in the translation of functional neuroimaging to real-world applications.
Apport de la décomposition arborescente pour les méthodes de type VNS

Actuellement, la resolution de problemes d'optimisation sous contraintes tire rarement parti de la structure du probleme traite. Or, il existe de nombreux problemes reels fortement structures dont la decomposition arborescente pourrait s'averer tres profitable. Les travaux menes jusqu'a present exploitent les decompositions arborescentes uniquement dans le cadre des methodes de recherche complete. Dans cette these, nous etudions l'apport des decompositions arborescentes pour les methodes de recherche locale de type VNS (Variable Neighborhood Search), dont l'objectif est de trouver une solution de tres bonne qualite en un temps limite. Cette these apporte trois contributions. La premiere est un schema generique (DGVNS), exploitant la decomposition arborescente pour guider efficacement l'exploration de l'espace de recherche. Trois differentes strategies visant a equilibrer l'intensification et la diversification de DGVNS sont etudiees et comparees. La seconde contribution propose deux raffinements de la decomposition arborescente. Le premier exploite la durete des fonctions de cout pour identifier les parties du graphe de contraintes les plus difficiles a satisfaire. Le second raffinement cherche a augmenter la proportion de variables propres dans les clusters. La troisieme contribution consiste en deux extensions de DGVNS qui exploitent a la fois le graphe de clusters et les separateurs. Chaque contribution proposee est evaluee et comparee au travers d'experimentations menees sur de multiples instances de quatre problemes reels.
Development of a Human–Robot Hybrid Intelligent System Based on Brain Teleoperation and Deep Learning SLAM

To achieve the better navigation performance of a mobile robot in the unknown environments, a novel human–robot hybrid system incorporating a motor-imagery (MI)-based brain teleoperation control is presented in this paper, where a deep-learning-based active perception is developed in the simultaneous localization and mapping (SLAM) framework. Using the deep-learning-based object recognition in the red–green–blue-depth (RGB-D) data acquisition process, the designed SLAM approach can select the valid feature points effectively, and the speed of displacement tracking can be improved by combining the oriented FAST and rotated BRIEF (ORB) SLAM algorithm with the optical flow method. The global trajectory map can also be mended using graph-based nonlinear error optimization. In addition, to build the connection between human intentions and the robot control commands flexibly in the developed mobile robot, a common spatial pattern (CSP)-based support vector machine (SVM) classification algorithm is proposed so that the control commands can be obtained directly from the human electroencephalograph (EEG) signals, which are preanalyzed and classified using the phenomena of event-related synchronization/desynchronization (ERS/ERD). Experiments involving several operators have verified the effectiveness of the proposed framework in the actual unstructured environments. Note to Practitioners—This paper is motivated by the exploration of the mobile robots remotely controlled by the disables in an unstructured environment that includes some unknown moving objects in the background. In the conventional approaches, the image feedback and the brain–computer interface-based EEG signals invoked by the visual stimulus are used to guide the motion of the robots. In this paper, the MI of left or right hand is adopted as an input of the brain teleoperation system, and the EEG signals are classified into two categories representing two robot control commands through the designed algorithm. Besides, a deep-learning-based SLAM is designed to analyze the image and depth of the environmental information provided by the robot RGB-D sensor, and the results can be transferred into a 3-D map locating the robot and assisting the operator to understand the operating environment. It has been verified that the deep-learning-based SLAM presented is more efficient and robust than traditional SLAM. The feasibility of the system is demonstrated by a set of experiments in the corridor environment.
Reduced blood pressure-lowering effect of catheter-based renal denervation in patients with isolated systolic hypertension: data from SYMPLICITY HTN-3 and the Global SYMPLICITY Registry.

AIMS Catheter-based renal artery denervation (RDN) has been shown to lower blood pressure (BP) in certain patients with uncontrolled hypertension. Isolated systolic hypertension (ISH) (systolic BP [SBP] ≥140 mmHg and diastolic BP <90 mmHg), characterized by increased vascular stiffness, is the predominant hypertensive phenotype in elderly patients. This study compared baseline characteristics and SBP change at 6 months between patients with ISH and combined systolic-diastolic hypertension (CH). METHODS AND RESULTS This study pooled data from 1103 patients from SYMPLICITY HTN-3 and the Global SYMPLICITY Registry. A total of 429 patients had ISH, and 674 had CH. Patients with ISH were significantly older than those with CH (66 vs. 55 years), had more type 2 diabetes mellitus (52.9 vs. 34.6%), and a lower estimated glomerular filtration rate (71.8 vs. 78.6 mL/min/1.73 m2); all P < 0.001. At 6 months, the SBP drop for CH patients was -18.7 ± 23.7 mmHg compared with a reduction of -10.9 ± 21.7 mmHg for ISH patients (-7.8 mmHg, 95% confidence interval, CI, -10.5, -5.1, P < 0.001). The change in 24-h SBP at 6 months was -8.8 ± 16.2 mmHg in patients with CH vs. -5.8 ± 15.4 mmHg in ISH (-3.0 mmHg, 95% CI -5.4, -0.6, P = 0.015). Presence of ISH at baseline but not age was associated with less pronounced BP changes following the procedure. The strongest predictor of office SBP reduction at 6 months was CH, followed by aldosterone antagonist use and non-use of vasodilators. CONCLUSION The reduction in BP among patients with ISH following RDN was less pronounced than the reduction in patients with CH. CLINICALTRIALSGOV IDENTIFIERS NCT01534299 and NCT01418261.
Impact Of Travel & Tourism On Economic Growth In India

Travel & Tourism is an important economic activity in most countries around the world. As well as its direct economic impact, the industry has significant indirect and induced impacts. Tourism is a major engine of economic growth and an important source of foreign exchange earnings in many countries including India. It has great capacity to create large scale employment of diverse kind – from the most specialized to the unskilled and hence can play a major role in creation of additional employment opportunities. It can also play an important role in achieving growth with equity. India has a dramatic growth of tourism over the last 25 years and it is one of the most remarkable economic change. Tourism activity has long lasting socio-economic impacts on the host economy and community. Now in India tourism is the large service industry with a contribution of 6.23% to the national GDP and providing 8.78% of the total employment. Keywords: Employment opportunities; Foreign versus domestic tourists; GDP; Tourism industry.
Extending a sentiment lexicon with synonym-antonym datasets: SWNetTR++

In our previous studies on developing a general-purpose Turkish sentiment lexicon, we constructed SWNetTR-PLUS, a sentiment lexicon of 37K words. In this paper, we show how to use Turkish synonym and antonym word pairs to extend SWNetTR-PLUS by almost 33 % to obtain SWNetTR++, a Turkish sentiment lexicon of 49K words. The extension was done by transferring the problem into the graph domain, where nodes are words, and edges are synonym--antonym relations between words, and propagating the existing tone and polarity scores to the newly added words using an algorithm we have developed. We tested the existing and new lexicons using a manually labeled Turkish news media corpus of 500 news texts. The results show that our method yielded a significantly more accurate lexicon than SWNetTR-PLUS, resulting in an accuracy increase from 72.2 % to 80.4 %. At this level, we have now maximized the accuracy rates of translation-based sentiment analysis approaches, which first translate a Turkish text to English and then do the analysis using English sentiment lexicons.
Live and carcass production traits for progeny of purebred sires in comparison with the clone of a USDA prime yield grade one carcass

Abstract Cloning is a technology by which an animal’s tissue can be salvaged and replicated. Carcasses that grade USDA prime–yield grade 1 (P1) represent a rare and antagonistic outcome and are a goal for terminal sire selection in the United States. A terminal sire progeny test generated offspring for a crossbred bull (14% Zebu, 86% Angus; ALPHA), born in 2012 via somatic cell nuclear transfer (SCNT) from a carcass that graded P1. ALPHA progeny (steers and heifers) were compared against progeny of three purebred (Angus; Charolais; Simmental) reference sires. Live production traits included weaning weight, morbidity, mortality, and days on feed; carcass traits included abscessed liver frequency and lung lesion frequency, individual quality and yield grade (YG) parameters, and carcass value. Observed carcass traits for progeny from the Angus, Charolais, and Simmental sires were reflective of the carcass outcomes expected for each sire’s respective breed. Calves sired by the Angus were the earliest maturing indicated by the youngest chronological age at harvest (P ≤ 0.02) concomitant with the most backfat (P < 0.01), and the greatest marbling scores (P < 0.01). Calves sired by the Charolais had the heaviest carcass weight (P = 0.04), greatest cutability as assessed by USDA calculated YG (P < 0.01) and were the heaviest muscled based on “longissimus” muscle area (P < 0.01). ALPHA-sired calves were the most similar in carcass outcomes to calves sired by the Simmental, combining advantageous quality and yield parameters to produce an intermediate for carcass quality and yield. The economic value of moderate carcass outcomes is reflected in the carcass value per century weight, in which ALPHA-sired steers tended (P = 0.07) to be of the greatest value compared to other sire groups. ALPHA progeny performed comparably to high-performing reference sires for terminal sire production traits and the P1 genetics in which ALPHA was cloned have economical and biological value in modern U.S. beef production.
The APSA journal list: popularity, purpose and performance

ABSTRACT For over a decade, the Australian Political Studies Association (APSA) has maintained a list ranking journals into A*, A, B and C bands. However, we know little about how Politics scholars use and view the list. In this study, we firstly discuss the history of the APSA list, before then presenting the results of an original survey conducted in March 2017 with over 250 members of the discipline. While the APSA list seems to enjoy overall support, we find that there are concerns about its purpose, its assessment of journal quality and how it treats different subfields and methodologies. In the discussion section, we address some of the main criticisms that have been made of the list and offer a number of suggestions for revisions. These include widening the consultation process, making submissions to the ranking committee public and extending the range of journals included in the list.