Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of refractory Hodgkin's lymphoma patients with an iodine-131-labeled murine anti-CD30 monoclonal antibody.

PURPOSE Hodgkin's lymphoma (HL) has been demonstrated to be a good target for immunotherapy since lymphocyte activation markers such as CD30 are expressed in high numbers on the malignant cells. Thus, we developed a new radioimmunoconjugate consisting of the murine anti-CD30 monoclonal antibody (MAb) Ki-4 labeled with iodine-131 ((131)I). PATIENTS AND METHODS The biodistribution of (131)I-Ki-4 was assessed via dosimetry after preinfusion of 5 mg native Ki-4 followed by 250 to 300 MBq (131)I-labeled Ki-4. Whole-body scintigraphy was performed 1 hour, 24 hours, 48 hours, 72 hours, and 6 days after the infusion. Dosimetry was calculated using the programs NucliDose ICON-IDL (version 5.0.2; Siemens, Erlanger, Germany) and MIRDOSE (version 3.1; Oak Ridge National Laboratories; Oak Ridge, TN). The therapeutic dose was given on day 8 after preinfusion of unlabeled Ki-4. RESULTS We treated 22 patients with relapsed or refractory CD30-positive HL. Preinfusion of 5 mg native Ki-4 was sufficient to bind the soluble CD30. Imaging demonstrated localization of involved areas measuring 5 cm in diameter or more in four patients and 2.5 cm in one patient. Patients received total body doses of 0.035 Gy to 0.99 Gy. Acute toxicity was mild with grade 1 fatigue in 19 of 22 assessable patients. Seven patients experienced grade 4 degrees hematotoxicity 4 to 8 weeks after treatment. Response included one complete remission, five partial remissions, and three minor responses. CONCLUSION Treatment with (131)I-Ki-4 is effective but can be associated with severe hematotoxicity.
Early loss of two renal grafts obtained from the same donor: role of ecstasy?

We read with interest the recent Transplantation paper by Dr. Hurault de Ligny et al. that describes early loss of renal grafts and a putative role for Ecstasy (1). We noted that their second hypothesis, hemostasis abnormalities, cites that antiphospholipid antibodies (aPL) were negative. We would like to ask the authors how many aPL specificities and isotypes were assessed? The two patients described in this report were receiving peritoneal dialysis prior to renal transplant. Our studies have shown that aPL-positive renal patients using peritoneal dialysis are at grave risk for renal transplant failure (2). We have found antiphosphatidylethanolamine (aPE) and antiphosphatidylcholine (aPC) associated with kidney transplant failure (3). Did they test for these particular aPL specificities? We note that often IgG and IgM aCL are the only aPL assessed in published studies. Moreover, did they test for IgA aPL? John A. McIntyre HLA-Vascular Biology Laboratory St. Francis Hospital Beech Grove, IN Department of Biology Indiana University Purdue University at Indianapolis Indianapolis, IN
Torque performance enhancement of V-shaped interior permanent magnet synchronous motor by rotor shape optimization

Interior permanent magnet (PM) synchronous motor (IPMSM) has been used in many fields, such as the air conditioner, electric tool, electric vehicles, etc., due to their high efficiency, high power density and wide speed range. However, the torque distortion and high cost of PM materials has limited the application of the IPMSM. In this paper, a technique to enhance the torque performance and minimize the PM consumption by optimizing the rotor shape is proposed. The characteristics, including back electromotive force (EMF), cogging torque, and torque ripple, of the IPMSM with different rotor shapes are analyzed by using the finite element method (FEM). Moreover, the prototype with the optimal rotor shape is built and tested, and the results show the good agreement between the FEM analysis and the tested value.
Shape quality measurement for 3D watermarking schemes

Shape quality assessment is a new challenge for a wide set of 3-D graphics applications and particularly for emerging 3-D watermarking schemes. In order to measure distortions new metrics have to be drawn between an original 3-D surface and its deformed version. These metrics are necessary to determine whether a deformation is perceptually acceptable and therefore whether this deformation should be considered while testing the robustness of a 3-D watermarking scheme. In this paper, we propose an objective metric based on the comparison of 2-D projections of the deformed and original versions of the shape. Rendering conditions are carefully specified as they play a key role on the human perception of the 3-D object. We compare the behaviors of this objective metric and of state-of-the-art metrics to subjective human perception for a set of deformations caused by watermarking schemes and usual watermarking attacks on several 3-D meshes. The protocol of these subjective psychovisual experiments is presented in detail. We discuss these experimental results for the purpose of the benchmarking of 3-D watermarking schemes.
Türkiye’de Eğitim Bilimleri ve Öğretmen Yetiştirme: Bir Yol Ayrımının Öyküsü

Dunyada egitim bilimleriyle Ilgili olarak surdurulen guncel tartismalar, insan ve toplum bilimlerindeki yeni acilimlarin egitim bilimlerine de dogrudan yansidigini, egitim bilimleri acisindan da hem kurumsal, hem de bilim pratigi acisindan paradigmatik degisim yarattigini gostermektedir. Turkiye'de ise, egitim bilimlerinin gelisim cizgisinin ve bugun geldigi noktanin, dunyadaki cagdas yonelimlerin cok uzaginda oldugu belirtilebilir. Egitim bilimlerinin Turkiye'deki tarihsel evrimi, bu disiplinin kendi zorunluluklari dogrultusunda dogal bir akis icinde gerceklesmemis, akademik normlara ve degerlere aykiri gerekcelerle disardan yonlendirilmistir. Bu acidan, egitim bilimlerinin Turkiye'deki tarihinin, bir mudahaleler tarihi oldugu ileri surulebilir. Ancak, YOK'un 1997 mudahalesi, egitim bilimlerine yonelik onceki mudahalelerden, gerek etki ve gerek kapsam bakimindan cok farkli olmustur. Egitim Fakultelerini yeniden yapilandirmayi amaclayan bu "duzenleme", ogretmen yetistirme alaninda cozdugunden daha fazla sorun yaratirken, egitim bilimlerinin de kurumsal varligini kelimenin tam anlamiyla ortadan kaldirmis ve bu disiplinin Turkiye'deki gelecegini tehlikeye sokmustur. Bu bildiride, soz konusu duzenlemenin yedi yillik bir bilancosunun cikarilmasi amaclanmistir. Baska bir anlatimla bildiride, Turkiye'de egitim bilimlerinin ve ogretmen yetistirme sisteminin son yedi yilda ugradigi agir tahribat konu edilmekte ve bu sorunun nasil asilabilecegine iliskin kimi onerilerde bulunulmaktadir.
Stock market prediction using neural network through news on online social networks

Stock market prediction has attracted a lot of attention from both business and academia. In this paper, we implement a model based on Recurrent Neural Networks (RNN) with Gated Recurrent Units (GRU) to predict the stock volatility in the Chinese stock market. We also propose many price related features which are used as inputs for our model. Apart from that, we carefully select official accounts from Chinese largest online social networks - Sina Weibo and extract the content posted by these accounts to analyze the public moods. An influence feature is derived based on the public moods to further improve the prediction model. The experimental results show that our model outperforms the baseline method and can achieve a good prediction performance.
Telemedicine and teledermatology: Past, present and future

Telemedicine is an emerging field within medicine with potential to revolutionize the delivery of health care.It is defined as the use of telecommunication technologies to transfer medical information.Teledermatology is a category of telemedicine. Early experiments were already made at the beginning of the 20th century, the breakthrough happened in the nineties because of the rapid progress of telecommunication technology. The latest advance is mobile telemedicine which is characterized by the use of mobile devices such as mobile phone and PDA (personal digital assistant). Advantages of telemedicine are the possibility of remote patient‐care as well as the easy and fast access to expert opinions and education.This can either happen through exchange of previously stored data/images (store‐and‐forward method) or in real time.Since our society is increasingly becoming interconnected via technical advances, it is essential that medicine also has an objective understanding of the topic.
Small mammals and their parasites (ixodid ticks) in urban forests and parks of St. Petersburg

Received 17 December 2008, revised 18 May 2009 Abstract. The biodiversity and abundances of small mammals and ticks inhabiting parks and forests of St. Petersburg were examined. No more than six species of small mammals were observed in each biotope. In localities with a low anthropogenic pressure, Myodes glareolus was dominant whereas in the territories with a serious anthropogenic load Sorex araneus or Apodemus agrarius dominated. Four tick species were collected from captured hosts: Ixodes persulcatus and I. ricinus represented by immatures and I. apronophorus and I. trianguliceps represented by immatures and adults.
Silicone composites for HV applications based on microvaristors

Microvaristors are small sintered particles of doped ZnO with strongly nonlinear electrical properties similar to those of the varistor ceramics. Composite materials based on a silicone matrix filled with microvaristor powder have a nonlinear current-voltage relation and can be used for field grading applications. The field dependence of the conductivity is determined by the properties of the filler particles, and can be tuned by modifying the formulation of the microvaristors and the sintering conditions as sintering time or temperature. In this contribution, we describe the nonlinear field grading material, and report on the development of a prototype field-grading element for a dry and compact high voltage termination, which has been successfully tested.
Germline mosaicism does not explain the maternal age effect on trisomy

A variety of hypotheses have been proposed to explain the association between trisomy and increasing maternal age in humans, virtually all of which assume that the underlying mechanisms involve meiotic errors. However, recently Hultén and colleagues [Hulten et al., 2010b] proposed a provocative model—the Oocyte Mosaicism Selection Model (OMSM)—that links age‐dependent trisomy 21 to pre‐meiotic errors in the ovary. Specifically, they propose that nondisjunctional events occur in a proportion of germ cells as they mitotically proliferate, resulting in mosaicism for trisomy 21. Assuming that the presence of an additional chromosome 21 delays meiotic progression, these cells would be ovulated later in reproductive life, resulting in an age‐dependent increase in aneuploid eggs. Because this model has important clinical implications, we initiated studies to test it. We first analyzed oocytes from two trisomy 21 fetuses, combining immunostaining with FISH to determine the likelihood of detecting the additional chromosome 21 at different stages of meiosis. The detection of trisomy was enhanced during the earliest stage of prophase (leptotene), before homologs synapsed. Accordingly, in subsequent studies we examined the chromosome content of leptotene oocytes in seven second trimester female fetuses, analyzing three chromosomes commonly associated with human trisomies (i.e., 13, 16, and 21). In contrast to the prediction of the OMSM, we found no evidence of trisomy mosaicism for any chromosome. We conclude that errors in pre‐meiotic germ cells are not a major contributor to human aneuploidy and do not provide an explanation for the age‐related increase in trisomic conceptions. © 2013 Wiley Periodicals, Inc.
Social Inclusiveness of Electronic Public Service Delivery in Germany - A Quantitative Analysis

Digital divide is, despite all efforts in research and practice, a matter of fact in most societies. In search for specific strategies to promote digital inclusion, one has to ask for what are the specific reasons and factors behind the problem. Here, the field of E-Government features several particular characteristics, including high privacy and security demands or high complexity of administrative processes, which might hinder the societal inclusiveness of such electronic public service delivery. Addressing the question of what could be possible explanations for a lack of inclusiveness in E-Government, we develop an E-Government-inclusion-gap-model and conduct a quantitative analysis of statistical data on E-Government usage in Germany, taking into account specific social digital divide groups, such as senior citizens, people with low education or people without employment. Here, we contrast E-Government usage with E-Commerce and internet usage. Specific inclusion gaps in E-Government and their underlying issues are analysed and specific recommendations given.
Peptidoglycan at its peaks: how chromatographic analyses can reveal bacterial cell wall structure and assembly

The peptidoglycan (PG) cell wall is a unique macromolecule responsible for both shape determination and cellular integrity under osmotic stress in virtually all bacteria. A quantitative understanding of the relationships between PG architecture, morphogenesis, immune system activation and pathogenesis can provide molecular‐scale insights into the function of proteins involved in cell wall synthesis and cell growth. High‐performance liquid chromatography (HPLC) has played an important role in our understanding of the structural and chemical complexity of the cell wall by providing an analytical method to quantify differences in chemical composition. Here, we present a primer on the basic chemical features of wall structure that can be revealed through HPLC, along with a description of the applications of HPLC PG analyses for interpreting the effects of genetic and chemical perturbations to a variety of bacterial species in different environments. We describe the physical consequences of different PG compositions on cell shape, and review complementary experimental and computational methodologies for PG analysis. Finally, we present a partial list of future targets of development for HPLC and related techniques.
Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type.

OBJECTIVE Symptom decline in attention deficit hyperactivity disorder (ADHD) was examined with different definitions of remission. METHOD Symptoms in 128 boys were measured five times over 4 years. The prevalences of syndromatic (less than full syndrome), symptomatic (less than subthreshold diagnosis), and functional (full recovery) remission were estimated as a function of age with multivariate logistic regression. RESULTS Age was significantly associated with decline in total ADHD symptoms and symptoms of hyperactivity, impulsivity, and inattention. Symptoms of inattention remitted for fewer subjects than did symptoms of hyperactivity or impulsivity. The proportion of subjects experiencing remission varied considerably with the definition used (highest for syndromatic remission, lowest for functional remission). CONCLUSIONS These results indicate that differences in reported remission rates reflect the definition used rather than the disorder's course. They provide systematic support for the clinical observation that hyperactivity and impulsivity symptoms tend to decline at a higher rate than inattention symptoms.
What's holding you back: why should (or shouldn't) employers invest in health promotion programs for their workers?

question we are often asked is: How can I convince my senior management that investing in the health and well-being of workers will save money and produce a positive return on investment (ROI)? If leadership of the organization has already made up its mind that health promotion programs are a waste of time and money, then it is next to impossible to convince them otherwise. If, on the other hand, leaders have not yet made up their minds, and importantly, if they have not been exposed to the body of evidence suggesting that worksite programs have the potential to improve workers’ health and lower company expenses, then there is hope. Below, we offer the main arguments in favor of increased employer investment in health promotion. We emphasize the economic rationale for such investment, rather than arguing that it is the “right thing to do” and a socially responsible way of treating one’s workers. We contend that health promotion programs not only improve worker health and well-being, but also produce bottom line effects.
A plasmid‐encoded regulator couples the synthesis of toxins and surface structures in Bacillus anthracis

Transcription of the major Bacillus anthracis virulence genes is triggered by CO2, a signal believed to reflect the host environment. A 180 kb plasmid, pXO1, carries the anthrax toxin genes and the genes responsible for their regulation, pagR and atxA; the latter encodes a major trans‐activator. It has long been known that pXO1 genes have major effects on the physiology of B. anthracis, probably through regulatory cross‐talk between plasmid and chromosomal genes. Accordingly, we found that the chromosomal S‐layer genes, sap and eag, are regulated by pXO1 genes so that only eag is significantly expressed in the presence of CO2. This effect results from the product of pagR acting as the most downstream element of a signalling cascade initiated by AtxA. In vitro evidence showed that PagR is a transcription factor that controls the S‐layer genes by direct binding on their promoter regions. This work provides evidence that AtxA is a master regulator that co‐ordinates the response to host signals by orchestrating positive and negative controls over genes located on all genetic elements.
DIFFERENCES BETWEEN LARVAL AND ADULT DROSOPHILA IN METABOLIC DEGRADATION OF ETHANOL

The alcohol dehydrogenase polymorphism in Drosophila melanogaster is a widely cited paradigm ofthe occurrence ofnatural selection (van Delden 1982). However, the fruit fly's life stages seem to vary substantially in sensitivity to selective forces of alcohols (e.g., Middleton and Kaeser 1983; Heinstra et al. 1987; Hoffmann and McKechnie 1991). Drosophila uses mainly alcohol dehydrogenase (ADH, EC 1.1.1.1) to detoxify dietary ethanol (for a recent review see Geer et al. 1991). Alcohol dehydrogenase has a dual function in larvae; dehydrogenation of ethanol into acetaldehyde and subsequently of acetaldehyde into acetic acid (Heinstra et al. 1983, 1989). Recently two independent investigations suggested that the enzyme aldehyde dehydrogenase (ALDH, EC 1.2.1.3) is more important than ADH for the dehydrogenation of acetaldehyde in adults (Anderson and Barnett 1991; Leal and Barbancho 1992). This points to differences in alcohol elimination between these life stages. Ethanol-derived (end)products, like fatty acids, a,a-trehalose, alanine, lactate, glutamate, glutamine, and proline have been detected in lar-
Ultrathin silicon solar cells with enhanced photocurrents assisted by plasmonic nanostructures

Thin-film photovoltaics offers the potential for a significant cost reduction compared to traditional photovoltaics. However, the performance of thin-film solar cells is limited by poor light absorption. We have devised an ultra-thin-film silicon solar cell configuration assisted by plasmonic nanostructures. By placing a one-dimensional plasmonic nanograting on the bottom of the solar cell, the generated photocurrent for a 200 nm-thickness crystalline silicon solar cell can be enhanced by 90% in the considered wavelength range, while keeping insensitive to the incident angle. These results are paving a promising way for the realization of high-efficiency thin-film solar cells.
The effect of short-term isometric training on core/torso stiffness

ABSTRACT “Core” exercise is a basic part of many physical training regimens with goals ranging from rehabilitation of spine and knee injuries to improving athletic performance. Core stiffness has been proposed to perform several functions including reducing pain by minimising joint micro-movements, and enhancing strength and speed performance. This study probes the links between a training approach and immediate but temporary changes in stiffness. Passive and active stiffness was measured on 24 participants; 12 having little to no experience in core training (inexperienced), and the other 12 being athletes experienced to core training methods; before and after a 15 min bout of isometric core exercises. Passive stiffness was assessed on a “frictionless” bending apparatus and active stiffness assessed via a quick release mechanism. Short-term isometric core training increased passive and active stiffness in most directions for both inexperienced and experienced participants, passive left lateral bend among experienced participants being the exception (P < 0.05). There was no difference between the inexperienced and experienced groups. The results confirm that the specific isometric training exercise approach tested here can induce immediate changes in core stiffness, in this case following a single session. This may influence performance and injury resilience for a brief period.
Application of wavelet and EMD-based denoising to phonocardiograms

Wavelet-based (WT) denoising has been frequently used as simple and efficient method enabling high signal-to-noise ratio. Moreover, by using second generation WT and lifting scheme, even better performance has been obtained. Besides the WT, empirical mode decomposition (EMD) is another efficient noise reduction technique, which enables adaptive decomposition based only on signal characteristics. Both WT and EMD denoising concepts find place in pre-processing of phonocardiograms (PCGs). Although these techniques are very effective in denoising, their inappropriate use can cause unwanted signal distortion. In this paper, we analyzed both denoising techniques and tested their influence to the degradation of PCGs, particularly regarding to some diagnostically relevant cardiac events, such as the first and second heart sound (S1 and S2) and clicks. It was shown that the morphology of S1, S2, and even the existence of subtle features (clicks) within the PCG, depend on the denoising method. Results of evaluation tests indicate which combination of denoising algorithm is the best choice for PCG signal pre-processing.