Miracle-dz/UniFAR-FTUs huggingface dataset:
Information, Complexity and the Detail

The proliferation of affordable computing has transformed the capability of architecture to deal with complex forms and details. As Dennis R Shelden, Chief Technology Officer of Gehry Technologies, explains, this has resulted in the production of an abundance of digital information or data. The intersection of two curved surfaces, for instance, is now much more complex than the surfaces themselves. Complexity requires more information and thus more processing, making details like this ultimately more expensive to produce. The jury is still out on what the future might hold, as architecture undergoes a period of fundamental transition in which, for the time being at least, there remains an essential mismatch between the surfeit of digital information and the tight economic limits on physical production.
An Engraving Character Recognition System Based on Machine Vision

In order to solve the problem of low efficiency, low quality and false detection of metal surface engraving character detection, we proposed a kind of engraving character recognition system based on machine vision. This system can identify and detect through the image acquisition of engraving area, and a series of mathematical and morphological treatments of binary image. It can extract the contour using optimized Laplace edge detection operator and combining with the convexity characteristic of engraved words. The system successfully carried out the experiment of engraving character recognition and it can detect the character recognition with high efficiency and high qualified rate. It has realized the automation of engraving character recognition test production line, and it has certain application value and promotion significance.
CBT and the challenge of primary care: developing effective, efficient, equitable, acceptable and accessible services for common mental health problems

Recent guidelines suggest that cognitive behavioural therapy (CBT) has a pivotal role to play in the treatment of common mental health problems (CMHPs). There is a danger that we simply ask for ‘more of the same’ instead of looking at all the current limitations preventing individuals from accessing appropriate help. Doing this leads us to aim for a more radical and innovative approach to the CMHPs. This paper suggests that progress in primary care mental health has been much more limited than mental health workers and, in particular, researchers often acknowledge. It looks at the major obstacles barring the way to the development of services that could meet the needs of the very large number of people in our communities with CMHPs.
DIABETES CONTROL – THE LEGACY OF A MEMORY

Achieving and maintaining good glycaemic control remains an important goal in the management of this common and prevalent disorder. Recent evidence from important megatrials, ACCORD, ADVANCE, VADT, UKPDS-10 year follow-up as well as the STENO-2 follow-up study, have cleared doubts concerning the benefits of targeting good glycaemic control. For the first time, we have the reassurance that macrovascular benefits can be realised from good glycaemic control. The legacy effect of prior good glucose control from the UKPDS-10 year follow-up, reinforces the results seen from the DCCT-EDIC (for Type 1 diabetes). The Intervention Phase of the UKPDS revealed benefits for reduction of microvascular complications, while it was only at the end of the Post-Trial Monitoring Phase where significant improvements in both micro and macrovascular outcomes were seen. (JUMMEC 2009; 12(2): 47-56)The other three Trials assessing the effect of glycaemic control on cardiovascular outcomes, although largely negative for CV benefit, give valuable insight towards appropriate patient characteristics for which aggressive glucose control can and should be instituted. Individualisingglycaemic targets, which has been the approach that many clinicians have been practising, has received new impetus albeit with clearer details. Getting to glycaemic goal early in the course of T2DM and Doing to Safely (Avoiding hypoglycaemia) are the key ingredients to successful management. The legacy of the memory of initial goodmetabolic/glycaemic control is investment in good health with benefits of reductions in both micro and more importantly, macrovascular disease, years later. Multifactorial interventions that include blood pressure, lipid lowering in addition to glucose control in these individuals with the Metabolic Syndrome result in more immediate beneficial additive effects on cardiovascular outcomes.
La notion de développement urbain durable appliquée au transport des marchandises

Peut-on dire que le developpement durable est un moteur de l'action locale sur le transport des marchandises ? A l'evidence pas encore. Certes, le developpement durable n'est plus un concept incantatoire, il a desormais sa place dans la planification des transports a moyen et long termes des villes. Un certain nombre d'experimentations. de logistique urbaine durable ont ete menees, et certaines avec succes. Mais au-dela de ces experiences, l'action effective et concrete des villes en matiere de transport durable des marchandises est tres limitee. Cette action est evaluee a travers l'analyse des actes reglementaires les plus banals qui soient : les arretes municipaux de circulation et de stationnement. Ces reglementations a destination des vehicules de livraison sont routinieres, fragmentees et peu efficaces. Les motifs de protection de l'environnement, notamment d'amelioration de la qualite de l'air, en sont encore aujourd'hui absents. Ce resultat est d'autant plus surprenant qu'aujourd'hui l'arsenal legislatif relatif au developpement durable n'est plus negligeable. L'article fait le point sur les textes s'appliquant aux collectivites locales relatifs au developpement durable. Il analyse les contentieux des tribunaux lies a la circulation des camions, avec une attention particuliere portee aux obligations des villes concernant la qualite de l'air. Il detaille les innovations recentes des villes europeennes, qui integrent des criteres environnementaux dans leur legislation municipale sur les livraisons.
Profil lipidique et statut des acides gras chez les patients avec trouble de déficit d'attention/hyperactivité (TDAH)

Attention-deficit hyperactivity disorder (ADHD) is the most common cognitive and behavioral disorder diagnosed among school children. Awareness has increased in recent years that this highly prevalent disorder estimated to affect 5-10% of children persists into adulthood, leading to 40% prevalence among adults. Genetic background and environmental factors have been proposed as risk factors for ADHD. Changes in nutrients and especially lipids, which represent 50-60% of brain dry weight, may influence the apparition of the disease. The aim of our study was to determine whether irregularities in lipid and lipoprotein profiles, as well as fatty acid composition and oxidants/antioxidants, were detectable in the plasma of young French-Canadian subjects with ADHD. Thirty seven patients (1lgirls and 26 boys), aged 6 to 12 years old, were inc1uded in the experimental protocol. They met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnostic criteria for attentiondeficitlhyperactivity disorder, were characterized with an IQ > 85, and compared to 35 healthy control subjects. Our results show that plasma triacylglycerols and phospholipids were lower whereas free cholesterol, high-density cholesterol and apolipoprotein A-I were higher in ADHD patients compared to controls. The proportion of plasma EPA and DHA was higher, but that of oleic (C18 :ln-9) (p<0.0001) and uVI linolenic (ALA) (p<O.04) acids were lower. As expected from these findings, the proportions of both total saturates and polyunsaturates fatty acids (PUF A) were higher and lower, respectively, in ADHD patients than in controls, which led to a significant decrease in the PUF As/saturates ratio (p<O.02). On the other hand, the ratios of eicosatrienoic acid to arachidonic acid and of palmitoleic acid to linoleic acid, established indexes of essential fatty acid (EF A) status remained unchanged revealing that EF A did not affect ADHD patients. Similarly, the activity of 86 desaturase, estimated by the ratio of 18:2(n-6)/20:4(n-6), was found unaffected, whereas ALAIEPA (p<O.02) and ALAILA (p<O.Ol) were diminished. Overall, significant changes occur in the lipid and lipoprotein profiles of ADHD patients. Disorders in n-3 FA distribution require further investigation to delineate the mechanisms
A hierarchical approach to probabilistic pursuit-evasion games with unmanned ground and aerial vehicles

We consider the problem of having a team of unmanned ground vehicles (UGV) and unmanned aerial vehicles (UAV) pursue a team of evaders while concurrently building a map in an unknown environment. We cast this problem in a probabilistic game-theoretic framework and consider two computationally feasible pursuit policies: greedy and global-max. We implement this scenario on a fleet of UGVs and UAVs by using a distributed hierarchical system architecture. Finally, we present both simulation and experimental results that evaluate the pursuit policies relating expected capture times to the speed and intelligence of the evaders and the sensing capabilities of the pursuers.
Biophysical Interactions of vaginal microorganisms

Vaginale gezondheid is altijd al belangrijk geweest. Echter, pas sinds kort wordt het steeds duidelijker hoe de vaginale gezondheid het beste gehandhaafd kan worden. Helaas zijn vaginale infecties een vaak voorkomend probleem, dat moeilijk te behandelen is en waarover bovendien nog maar weinig bekend is. Infecties worden vaak veroorzaakt door veranderingen in de samenstelling van de vaginale microbiota en kunnen leiden tot ernstige gezondheidsproblemen voor de vrouw en/of haar ongeboren kind. Normale vaginale microbiota (meestal Lactobacillus sp.) en probiotische bacterien bieden hier veelbelovende kansen voor preventie en therapie. De focus van dit proefschrift ligt op het belang van de adhesie tussen de vaginale bacterien (pathogenen en lactobacilli) en tussen bacterien en vaginale cellen, waarbij gekeken wordt hoe dit de condities in een vaginale infectie kan beinvloeden (b.v. inflammatie, biofilm formatie, productie van toxines etc.). Adhesieve lactobacillen (lactobacillen die aan elkaar of aan de celwand vastkleven) zijn beter in staat om pathogene virulentie, inflammatie en biofilm formatie te voorkomen dan niet-adhesieve lactobacillen. Pathogenen blijken beter aan vaginale cellen vast te kleven, terwijl lactobacillen beter aan de pathogenen zelf vastkleven. Dit laatste verschijnsel is mogelijk het mechanisme dat de gunstige werking van lactobacillen verklaart. Samenvattend kunnen we concluderen dat adhesie door de vaginale bacterien een belangrijke factor is die nog beter onderzocht moet worden.
Archaeology in Jordan, 2002 Season

the end of the report. We would like to thank the Department of Antiquities of Jordan, its Director, Dr. Fawwaz al-Khraysheh, and his staff for their continued efforts and support on behalf of all those who are committed to understanding and preserving the cultural heritage of Jordan. Publication of this year's "Archaeology in Jordan" newsletter was once again made possible in part by contributions from the Jordan Society and the American Center of Oriental Research.
PENTOXIFYLLINE IN ACUTE ISCHEMIC STROKE PATIENTS WITH BLOOD HYPERVISCOSITY

Objective: This study evaluated the efficacy of pentoxifylline, a hemorrheologic agent, for treating acute ischemic stroke in patients with bloodhyperviscosity.Methods: Patients were randomly allocated within 3 days of stroke onset to study or control treatment. All the patients received the standard acuteischemic stroke treatment. The study treatment was intravenous pentoxifylline 1200 mg/day for 5 consecutive days and oral pentoxifylline 800 mgin two divided doses for 23 days. Blood viscosity was evaluated on days 7 and 30. The outcomes were assessed by the National Institutes of HealthStroke Scale (NIHSS), modified Rankin Scale, and Barthel index (BI) criteria.Results: The median baseline viscosity was 6.89 poise in the study and 6.46 poise in the control groups and had decreased in all the patients ondays 7 and 30. The decrease in the study group on day 7 (1.13 poise) was greater than that in the control group (0.57 poise); the difference was notsignificant. The NIHSS score improved by 32% in the study group (relative risk [RR]=1.00, 95% confidence interval [CI]: 0.421–3.556; p=1.00). At1-month, 67% of the study group had a good functional outcome (RR=1.026, 95% CI: 0.656–1.605; p=0.909). Conclusion: Pentoxifylline decreased blood viscosity and improved clinical outcome in this patient series.
Pharmakologische Charakterisierung und QSAR-basiertes Design neuartiger Liganden des FFAR1 (Freie-Fettsäure-Rezeptor 1)

Der G-Protein-gekoppelte Freie-Fettsaure-Rezeptor 1 (FFAR1, fruher GPR40) gilt als ein interessantes Zielprotein fur die Entwicklung von Wirkstoffen zur Behandlung des Typ 2-Diabetes mellitus. Eine Aktivierung des FFAR1 fuhrt zu einer Steigerung der Insulinsekretion aus pankreatischen β-Zellen. Zwei potente FFAR1-Agonisten TAK-875 (TAKEDA) und AMG837 (AMGEN) befinden sich in der klinischen Prufung. Ziele dieser Arbeit waren 1) die Identifizierung und pharmakologische Charakterisierung neuer hFFAR1-Liganden, 2) die Analyse der Struktur-Wirkungsbeziehungen (SAR) unter Einbeziehung der Ligandbindungstasche, 3) das Design verbesserter Liganden basierend auf dem QSAR-Modell, sowie 4) die ex vivo und in vivo Untersuchung von TUG 469, dem bis dahin potentesten in dieser Arbeit identifizierten FFAR1-Agonisten an β-Zellen der Ratte sowie an NZO-Mausen im Glucosetoleranz-Test. Insgesamt wurden uber 450 mogliche hFFAR1-Liganden aus der Arbeitsgruppe von Prof. Ulven (University of Southern Denmark) am rekombinanten Zellsystem funktionell untersucht. Hiervon konnten 238 als hFFAR1-Agonisten und 3 als neue kompetitive hFFAR1-Antagonisten identifiziert und charakterisiert werden. Aus der Wirkstarke und den physikochemischen Eigenschaften von 171 hFFAR1-Agonisten wurden mit Hilfe von AFMoC deskriptive SAR abgeleitet. Das Modell stellte sich nach einer datensatzinternen Prufung („Leave-One-Out“-Kreuzvalidierung, q2= 0,61) sowie einer Prufung mit einem unabhangigen Testdatensatz (26 Verbindungen, q2= 0,66) als valide heraus und ermoglicht das zielgerichtete Design neuartiger hFFAR1-Agonisten. Zwei dieser Strukturentwurfe wurden von Prof. Ulven synthetisiert und in dieser Arbeit in vitro charakterisiert. Die Vorhersage der Wirkstarke fur beide Substanzen war korrekt (pEC50pred = pEC50exp ± 0,35). Das AFMoCModell erweist sich als valide Methode zum Design neuer und potenter hFFAR1-Agonisten. TUG 469 (EC50 an hFFAR1: 17 nM) wurde an β-Zellen der Ratte (ex vivo) und in einer Studie an diabetogenen NZO-Mausen untersucht. In den β-Zellen der Ratte konnte eine gesteigerte Insulinsekretion nachgewiesen werden. Bei NZO-Mausen verbesserte sich unter TUG 469 die Glucosetoleranz. Zusammengefasst hat diese Arbeit TUG 469 als Kandidaten fur weiterfuhrende praklinische Studien ermittelt. Das AFMoC-Modell ermoglicht die Optimierung pharmakodynamischer Eigenschaften von hFFAR1-Liganden. Eine Synthese weiterer in dieser Arbeit vorgeschlagener Strukturen scheint viel versprechend.
Hypoglycemia in Diabetic - The Role of New Technologies

Twenty-eight years old Bahraini male known diabetic since birth was suffering from frequent attacks of hypoglycemia mandating visits to the Accident and Emergency Department. His blood biochemistry parameters were normal except for the high HbA1c. His general examination was normal. Several treatment regimens were initiated to combat his hypoglycemia with little success. New insulin analogue was prescribed for the patient to reduce the magnitude and frequency of hypoglycemic attacks and improve the blood sugar control. This method of treatment combined with dietary interventions proved effective in reducing the hypoglycemic attacks in clinical trials.
Study on College English Translation Teaching Strategies Based on the Perspective of Data Fusion and Cultural Construction

In order to improve the efficiency and accuracy in translation teaching, the paper researches on the College English translation teaching strategies based on the perspective of data fusion and cultural construction. At present, the focus of English translation teaching is focused on the teaching of English major translation. This paper analyses the current situation of College English translation teaching in China and discusses its countermeasures. The perspective of data fusion and cultural construction is proposed in this paper to deal with the experiment data. The result shows the proposed method can improve the overall performance in the teaching cases in this paper.
More Cinematic Ticklers for the OM Classroom

to any of thesequestions, we are back again with an up-date on the use of “cinematic ticklers” inthe classroom. In this column, we willbriefly review basic uses of ticklers, pro-vide some pointers for using them, andclose with a new list of ticklers that youcan use either as additions to those fromour previous article, or as replacements.Over the course of the article, we will usesome of our new suggested ticklers as ex-amples.
What is the role of post-operative physiotherapy in general surgical Enhanced Recovery after Surgery pathways?

Abstract Purpose: Enhanced Recovery after Surgery (ERAS®) has improved outcomes following elective surgery. This narrative review aimed to assess current evidence for post-operative physiotherapy interventions in general surgical procedures which adopt ERAS® principles. Materials and methods: A systematic review of the literature between 2000 and 2017 was conducted. Randomised controlled trials (RCTs) that compared physiotherapy interventions for patients after the following elective ERAS® procedures were included: gynaecologic, gastrectomy, gastrointestinal, pancreatic, bariatric, head and neck, breast, cystectomy, colorectal, colonic and liver. Results: One study (two publications) was found to compare post-operative physiotherapy interventions in radical cystectomy patients on an ERAS® pathway. The addition of a progressive exercise-based intervention improved aspects of health-related quality of life (dyspnoea (p <.05), constipation (p <.02) and abdominal flatulence (p ≤ .05)). Enhanced mobilisation was achieved, but no differences were observed in length of stay or severity of complications. Conclusions: It is essential that the paucity of research to assess post-operative physiotherapy interventions within ERAS® cohorts is highlighted. The results of our literature search highlight that there is a role for post-operative physiotherapy in ERAS® pathways. However, without well-conducted RCTs to evaluate procedure-specific interventions, the optimal type, timing, and dose will not be found and the potential for improving patient functional recovery will be limited.
Evaluation of the quality of prescriptions with antibiotics in the government hospitals of Yemen

Introduction: Irrational prescribing is a habit which is difficult to counteract and this may lead to ineffective treatment, health risks, patient non-compliance, drug wastage, wasting resources and needless expenditure. Objective: The aims of this study were to investigate the prescribing of antibiotics in Yemen and provide a baseline picture of prescribing habits. It presented an overview on the quality of prescribing and the resulting patterns coming from the prescriptions. Methods: The scope of the study was limited to four public quaternary health care facilities in Sana’a, Yemen. A prospective drug utilization review method was used in this study. Results: Results showed that the total number of brand name antibiotics prescribed was 76.8%, and 27.5% of the antibiotics were not on the Yemen Essential Drug List (YEDL). Out of all prescriptions, it was found that 51.0% contained antibiotics. Antibiotic prescriptions were lacking in many areas of important information: the diagnosis, patient’s name, gender and age as well as for the prescribed antibiotics information (strength, dosage form, dose, frequency and duration). The average number of antibiotics per each patient received was 1.2 ± 0.4(median = 1) and the percentage of antibiotics prescribed as injections was 27.8%. Conclusion: The patterns which emerged in prescribing showed that there were various potential problems in antibiotic usage in the government quaternary hospitals in Yemen. Advocacy, education and awareness initiatives are required to alleviate these problems.
De effecten van waterkracht en visserij tijdens de stroomafwaartse trek van schieraal in de Maas: zender-onderzoek gedurende 2002 - 2006

In deze rapportage worden de belangrijkste conclusies en resultaten gepresenteerd van een in opdracht van het Ministerie van LNV uitgevoerde studie naar effecten van visserij en waterkracht en andere sterftefactoren tijdens de stroomafwaartse migratie van schieraal gedurende 2002-2006. Deze rapportage is gebaseerd op een viertal wetenschappelijke publicaties die zijn opgesteld en een EU rapportage in samenwerking met KEMA, RIZA en twee Duitse partners (EU-project SILVEREEL).
High affinity Fc receptor binding and potent induction of antibody-dependent cellular cytotoxicity (ADCC) in vitro by anti-epidermal growth factor receptor antibody cetuximab

3041 Background: Cetuximab is an IgG1 monoclonal antibody specific for human epidermal growth factor receptor (EGFR). Cetuximab acts as a functional antagonist by blocking ligand (EGF and TGFa) binding to EGFR and, therefore, inhibits EGFR activation and downstream signaling in tumor cells. Methods: In the present study, we analyzed the binding activity of cetuximab to human Fc receptors and tested whether cetuximab can elicit antibody-dependent cellular cytotoxicity (ADCC) in vitro using tumor cell lines expressing various levels of EGFR. Results: Cetuximab bound to human FcRI and FcRIII with high affinity (EC50 of 0.13 nM and 6 nM, respectively), whereas an aglycosylated form of cetuximab or an IgG2 antibody to EGFR (panitumumab) did not bind to FcRI and FcRIII. A panel of head and neck, colon, and breast tumor cell lines were tested for cetuximab-mediated ADCC using human peripheral blood mononuclear cells (PBMC) from normal donors as effector cells. We found that cetuximab-induced ADCC to these tumor .
Chapter 7 The Role of Mentoring in Youth Entrepreneurship Finance: A Global Perspective

Contribution and Implications The chapter provides both statistical and qualitative evidences supporting the premise that youth business mentoring can both improve access to external finance and lead to improved business performance. This provides useful guidance to youth business support, given that in some of the countries studied, external financing in the form of grants and soft micro loans for youth entrepreneurs are not available.