Miracle-dz/UniFAR-FTUs huggingface dataset:
Does CEO Turnover Affect Stock Market Performance through Company Performance in Indonesian Companies?

This study analyzes whether CEO turnover affects stock market performance through company performance in Indonesian companies. Specifically, this study examines: (1) Does the CEO turnover affect the stock market performance? (2) Does the CEO turnover affect the company performance and (3) Does the CEO turnover affect the stock market performance through the company performance? This study does not test the CEO turnover due to death, forced resignation, voluntary departures, and age-related retirement considering that almost all companies in Indonesia are family companies. This study uses the manufacturing companies listed on the Indonesia Stock Exchange as an analysis unit with the study period during 2010-2015. The finding of this study concludes that (1) the CEO turnover has a positive effect on the stock market performance, (2) the CEO turnover has a positive effect on the company performance, and (3) the CEO turnover does not affect the stock market performance through the company performance. This study has an implication from a theoretical perspective, i.e. the CEO turnover has a positive effect on the stock market performance and the company performance. However, CEO turnover does not affect the stock market performance through company performance. Then, the company performance is not an intervening variable of the effect of the CEO turnover on the stock market performance.
Alkalinization and Precipitation Characteristics of 0.2% Ropivacaine

Background and Objectives Alkalinization of local anesthetics has been used to increase the speed of onset of nerve blocks. However, alkalinization of local anesthetic solutions may cause precipitation, thereby decreasing bioavailability and anesthetic activity. Alkalinization of ropivacaine has not been described. This laboratory study assessed the alkalinization and precipitation characteristics of ropivacaine. Methods Aliquots (2 mL) of commercially available ropivacaine (Naropin, 0.2%; Astra Pharmaceutical, West-borough, MA) were alkalinized with increasing amounts (0.01, 0.02, 0.04 mL) of sodium bicarbonate (8.4%) and immediately monitored for pH change and onset of visible precipitation at room temperature. We then alkalinized ropivacaine with sodium bicarbonate and measured the amount of precipitate that accumulated after various incubation times. Results The pH of ropivacaine increases with the addition of small amounts of bicarbonate. The calculated percentage of nonionized ropivacaine increased from 0.3% to greater than 30% with alkalinization from pH of 5.51 to 7.63. Drug loss to precipitation increased with higher doses of bicarbonate, reaching 25% to 30% of the total ropivacaine. Even with a low dose of bicarbonate (0.1 mL bicarbonate/20 mL ropivacaine), precipitation increased with time of incubation, reaching a plateau at 20 minutes. Conclusions A laboratory evaluation that establishes the alkalinization characteristics of ropivacaine is a prerequisite for designing a clinical study of alkalinized ropivacaine. In our experiment, low doses of bicarbonate produced significant increases in the proportion of nonionized ropivacaine with only modest precipitation. There would be a low likelihood of substantial drug precipitation if the mixture was administered within 5 to 10 minutes after alkalinization. These results indicate that alkalinized ropivacaine should not be used for infusions and that ropivacaine should not be alkalinized until just before use.
A video stabilization algorithm for train-mounted intrusion detection system based on ALP keypoints

With the rapid increasing of railway mileage, automatic railway intrusion detection by analyzing the video from train-mounted camera is becoming very meaningful. But there exits serious jitter in the video since the camera always vibrates with train when it is running, a video stabilization reprocessing procedure is the prerequisite before the intrusion detection analysis. To solve this question, a robust video stabilization algorithm based on low degree polynomial detector is presented in this paper. Generally, this algorithm consists of three stages. Firstly, keypoints are extracted and tracked by ALP detector and KLT tracker respectively between adjoining frame of the video. Secondly, the local motion vector is obtained by image affine transformation model. Finally, the global motion vectors are corrected and smoothed by using RANSAC and Kalman filter respectively. At the end of this paper, experiments based on PSNR and ITF values are given to show that the proposed algorithm is more effective than Harris corner detector which is often used in the traditional stabilization algorithm.
A Stable Grasping and Manipulating Control Method Based on Grasp Plane

In this paper, a method for dividing grasping and manipulating control into grasp plane control and inside grasp plane control is proposed. Grasp plane control is realized by controlling center of gravity (COG) of three end-effectors and posture of the grasp plane. Inside grasp plane control is realized by controlling grasping shape and contact force which exists on the grasp plane. To avoid any danger entailed by dropping of a grasped object, a method for compensating contact force to a grasped object by external force is also proposed. This external force is estimated from normal force, and this force is not affected by frictional force. Thus, stable grasping and manipulating control taking external force parallel to the grasp plane into account is realized. The validity of the proposed systems is confirmed by the experimental results
Evidence for a depressor reflex elicited from left ventricular receptors during occlusion of one coronary artery in the cat.

Circulatory responses to shortlasting occlusions of one coronary artery (left anterior descendent or right coronary artery) were studied in chloralose-anesthetized cats. — When the carotid sinus baroreceptors were left functionally intact, coronary occlusion induced moderate reflex reductions of heart rate and blood pressure and slight increases of resistance and capacitance vessel tone in the calf muscles. When the buffering influences from the baroreceptors were largely eliminated by bilateral carotid occlusion, the reflex fall of blood pressure and heart rate became more pronounced and a clearcut vasodilatation was now observed. After cold block of the cervical vagi, the blood pressure fall upon coronary obstruction was markedly diminished, the heart rate response was reversed to a slight tachycardia and a marked peripheral vasocon-striction ensued. After i.v. administration of local anesthetics (lidocaine 3–4 mg/kg b.wt.) the reflex response to coronary obstruction and to shortlasting occlusions of the ascending aorta were almost completely eliminated. — It is concluded that acute occlusions of one coronary artery induce a reflex bradycardia and vasodilatation, in all probability due to activation of left ventricular mechanoreceptors. The vascular responses in this inhibitory reflex seem to be significantly moderated by influences from the arterial baroreceptors.
Multi-lineage potential of fetal cells in maternal tissue: a legacy in reverse

Fetal cells circulate in pregnant women and persist in blood and tissue for decades post-partum. The mother thus becomes chimeric. Factors that may influence such fetal cell microchimerism include histocompatibility, fetal or placental abnormalities, or a reproductive history that includes miscarriage or elective termination. Fetal cell microchimerism is associated with some maternal autoimmune diseases, such as systemic sclerosis. Moreover, a novel population of fetal cells, the pregnancy-associated progenitor cells (PAPCs), appears to differentiate in diseased or injured maternal tissue. The cellular origin of these cells is at present unknown but could be a hematopoietic stem cell, a mesenchymal stem cell, or a novel cell type. Pregnancy therefore results in the acquisition of cells with stem-cell-like properties that may influence maternal health post-partum. Rather than triggering disease, these cells may instead combat it.
Separation methodology to improve proteome coverage depth

So-called ‘in-depth proteomics’ and its applied separation methodology to improve the proteome coverage depth has become an important issue in mass spectrometric-based proteomics and system-wide cell biology studies. Employing a bottom-up approach and a variety of separation techniques, it allows for identification of proteins with low copy numbers and enables researchers to correlate the number of expressed genes in a cell with the proteome. Here we describe recent advances in this field with emphasis on peptide and protein separation technologies. The discussion is focused both on single injection analyses employing long reversed phase liquid chromatography separations of peptides (‘single shot proteomics’) and on the combination of orthogonal protein and peptide separation methods to achieve maximum protein coverage. Owing to these improvements, in-depth proteomics has now fully entered the field and is being implemented in an increasing number of laboratories.
Mycobacteria, metals, and the macrophage

Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation trafficking inside infected macrophages to ensure survival and replication inside the phagosome. Here, we describe the recent fascinating discoveries that the mammalian immune system responds to infections with M. tuberculosis by overloading the phagosome with copper and zinc, two metals which are essential nutrients in small quantities but are toxic in excess. M. tuberculosis has developed multi‐faceted resistance mechanisms to protect itself from metal toxicity including control of uptake, sequestration inside the cell, oxidation, and efflux. The host response to infections combines this metal poisoning strategy with nutritional immunity mechanisms that deprive M. tuberculosis from metals such as iron and manganese to prevent bacterial replication. Both immune mechanisms rely on the translocation of metal transporter proteins to the phagosomal membrane during the maturation process of the phagosome. This review summarizes these recent findings and discusses how metal‐targeted approaches might complement existing TB chemotherapeutic regimens with novel anti‐infective therapies.
Microvascular dysfunction in patients with cardiac syndrome X

Ever since Cannon and Epstein1 coined the term “microvascular angina” to describe syndrome X in 1988, the theory that a significant proportion of patients with syndrome X have microvascular dysfunction that leads to ischaemia, ST-depression, and chest pain has dominated the field of syndrome X research. This is surprising in view of the fact that the studies looking at the presence of ischaemia and microvascular dysfunction are poorly conducted and have inconsistent results. Despite publication bias, there are numerous negative studies demonstrating the lack of ischaemia in syndrome X patients when compared to controls. Indeed when Cannon himself did a well conducted study into microvascular dysfunction and found negative results, he concluded that invasive measurements of endothelium-dependent and endothelium-independent agonists is unlikely to be of value …
Opportunistic link overbooking for resource efficiency under per-flow service guarantee

The trade-off between resource efficiency and Quality of Service (QoS) is always a vital issue for communication networks, and link overbooking is a common technique used to improve resource efficiency. How to properly overbook a link and analytically determine its overbooking factor under QoS constraints are still problems, especially when achieving advanced QoS by per-flow queueing, as urged by the emerging mobilized applications in the access networks. This paper first proposes an Opportunistic Link Overbooking (OLO) scheme for an edge gateway to improve its link efficiency, and then develops an integrated analytical framework for determining the suitable link overbooking factor with service guarantee on flow level. In our scheme, once the idle time of a high priority flow's quasi-dedicated link is larger than a specified threshold, the link is temporarily overbooked to a low priority flow; and then when the high priority flow's subsequent packets start arriving, the link can be recovered at the expense of a setup delay. To explore the balance between link efficiency and the flow's QoS in the proposed scheme, we develop the corresponding queueing model under either bounded packet delay (relevant to delaysensitive flow) or finite buffer size (relevant to loss-sensitive flow). Our queueing analysis reveals the inherent trade-offs among the link overbooking factor, packet loss rate and delay/jitter under different traffic patterns.
Communicating prognosis in early breast cancer: do women understand the language used?

To THE EDITOR: We read with interest the two recent Journal articles regarding communication with women who have breast cancer. '> Communicating diagnostic and prognostic information to people with cancer will always be difficult for clinicians and nurses. One avenue of help in improving communication is to consult with the consumer groups which promote the views and welfare ofpeople suffering from disease. The Breast Cancer Action Group NSW is one such group. Its members include trained advocates who could, for instance, have provided valuable input to the study by Lobb et al,' especially during the early stages of designing the questionnaire. One of the messages coming out of the International Clinical Trials Symposium, held in Sydney in September 1999, was that the Internet has irrevocably altered medicine by allowing individuals to access medical information independently of the doctor-patient interaction. Consumers are becoming more informed and more vocal when it comes to making decisions about their treatment, and this inevitably results in a heightened need for clear understanding between clinicians and patients. In the field of clinical trials, Linda Ward, from Birmingham (UK), quoted a systematic review of 282 papers" which found that patients would enter and remain with trials if adequate time was given to explain the nature and significance of their joining. Also, they were more likely to stay in trials if they had been personally involved in designing them. Other speakers pointed out that, if the results of trials are to be translated into changes in clinical practice, they must be relevant to users, both patients and doctors. There may be some suspicion that consumer groups are likely to be adversarial in nature, and there is no doubt that they are seeking changes in many fields of treatment, as well as input into decisions about what research needs to be carried out. However, the intention of the groups is to assist researchers and clinicians to improve outcomes for both doctors and patients. Those wishing to contact a consumer body can call the Consumers' Health
Neurotrophin expression and laryngeal muscle pathophysiology in response to recurrent laryngeal nerve-crush injury

Laryngeal palsy often results from recurrent laryngeal or vagal nerve injury during oncologic surgery of the head and neck. The aim of this study was to describe the characters of spontaneous reinnervation in rats following recurrent laryngeal nerve (RLN) crush injury. Twenty-five male Sprague-Dawley rats each were subjected to a 5-mmlong crush injury to the right recurrent laryngeal nerve. Vocalization, vocal fold movements, histological factors (e.g., axonal diameters, axon numbers), and immunostaining measures of neurotrophin activity were recorded at different time points (i.e., 3 weeks, 6 weeks, 10 weeks, and 16 weeks) following injury. Results showed that vocalization and vocal fold movement were restored at week 16. The expression of brain-derived neurotrophic factor (BDNF) and glial-cell-line-derived neurotrophic factor (GDNF) was different in thyroarytenoid (TA) and posterior cricoarytenoid (PCA) muscles. The number of axons returned to baseline at week 16, whereas axon diameter was not statistically significantly different between the injured and control axons at week 10. During regeneration of RLN, differences in the expression of neurotrophic factors may lead to the preferential reinnervation of TA. The study shows that application of neurotrophic factors could help restore recurrent laryngeal nerve function.
Cervical Intervertebral Disc Degeneration and Low Cervical Extension Independently Associated With a History of Stinger Syndrome

Background: Stinger syndrome frequently occurs in athletes who compete in collision sports. Sharp pain and impairment of neck motion are major symptoms. Cervical intervertebral disc degeneration (CIDD) is also frequently observed in those who compete in collision sports. Purpose/Hypothesis: To investigate whether CIDD and neck functionality are related to a history of stinger syndrome. The hypothesis was that a significant relationship exists between CIDD and neck motion and a history of stinger syndrome in Japanese collegiate football players. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 49 male Japanese collegiate football players (mean age, 20.0 ± 1.1 years; mean athletic experience, 3.8 ± 2.3 years; mean height, 172.3 ± 4.8 cm; mean weight, 83.1 ± 12.2 kg) were subdivided into athletes with stinger syndrome (stinger group) and those without (control group). Stinger syndrome was confirmed based on a questionnaire and interview. CIDD was assessed by using T2-weighted magnetic resonance imaging. Range of motion (ROM) and isometric muscle strength were measured for neck function testing. Results: Thirty-nine percent (19/49) of athletes had at least 1 episode of stinger syndrome. The prevalence of CIDD was significantly higher in the stinger group (68%) than in the control group (30%) (P < .01). A statistically significant difference in cervical extension ROM was found between the stinger group (50.9° ± 11.1°) and the control group (60.2° ± 11.4°) (P < .01). Logistic regression analysis showed that CIDD and low cervical extension were independently associated with a history of stinger syndrome. Conclusion: Study results suggest that stinger syndrome is associated with CIDD and low cervical extension in collegiate football players.
Image-guided surgery: From X-rays to Virtual Reality

Since the discovery of X-rays, medical imaging has played a major role in the guidance of surgical procedures. While medical imaging began with simple X-ray plates to indicate the presence of foreign objects within the human body, the advent of the computer has been a major factor in the recent development of this field. Imaging techniques have grown greatly in their sophistication and can now provide the surgeon with high quality three-dimensional images depicting not only the normal anatomy and pathology, but also vascularity and function. One key factor in the advances in Image-Guided Surgery (IGS) is the ability not only to register images derived from the various imaging modalities amongst themselves, but also to register them to the patient. The other crucial aspect of IGS is the ability to track instruments in real time during the procedure, and to portray them as part of a realistic model of the operative volume. Stereoscopic and virtual-reality techniques can usefully enhance the visualization process. IGS nevertheless relies heavily on the assumption that the images acquired prior to surgery, and upon which the surgical guidance is based, accurately represent the morphology of the tissue during the surgical procedure. In many instances this assumption is invalid, and intra-operative real-time imaging, using interventional MRI, Ultrasound, and electrophysiological recordings are often employed to overcome this limitation. Although now in extensive clinical use, IGS is often currently perceived as an intrusion into the operating room. It must evolve towards becoming a routine surgical tool, but this will only happen if natural and intuitive human interfaces are developed for these systems.
Release of Particles Containing Metals from Vegetation into the Atmosphere

Studies with radioisotopes indicate that in the laboratory pea plants and pine tree seedlings release zinc and lead into the atmosphere. Field studies carried out on radiolabeled plots vegetated with a variety of grasses and small herbaceous plants also show that these elements are released into the atmosphere. The metals, associated with particles of various sizes, are released from the plant surfaces, and the loss mechanism is influenced by growth conditions, the concentrations of the elements in the leaves, and meteorological factors. For plants whose leaves have about equal concentrations of zinc and lead, the amount of zinc released is usually two orders of magnitude greater than the amount of lead. The significance of the process is discussed in terms of the overall trace metal composition of atmospheric particulates.
A Fuzzy Goal-Programming Model for Optimization of Sustainable Supply Chain by Focusing on the Environmental and Economic Costs and Revenue: A Case Study

Sustainable supply chain has become an integral part of the corporate strategy. In this paper, a real case study of the natural gas supply chain has been investigated. Using concepts related to natural gas industry and the relations among the compo-nents of gas and oil wells, refineries, storage tanks, dispatching, transmission and distribution network, a seven-level supply chain has been introduced and present-ed schematically. The aim of this paper is to optimize a case study using a fuzzy goal-programming multi-period model considering environmental and economic costs and revenue as fuzzy goals and maximize the total degree of satisfaction of goals as objective function. A small-sized problem was solved using GAMS 23.2. 1 software and sensitivity analysis was conducted on its parameters. To the best of our knowledge, this is the first study that presents a fuzzy goal program-ming model for the optimization of sustainable natural gas supply chain by focus-ing on the environmental and economic costs and total revenue of gas products and the other main contribution of this research is focused to the developing of the mentioned model.