Miracle-dz/UniFAR-FTUs huggingface dataset:
Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort study.

OBJECTIVE Schizophrenia is associated with premature mortality, but the specific causes and pathways are unclear. The authors used outpatient and inpatient data for a national population to examine the association between schizophrenia and mortality and comorbidities. METHOD This was a national cohort study of 6,097,834 Swedish adults, including 8,277 with schizophrenia, followed for 7 years (2003-2009) for mortality and comorbidities diagnosed in any outpatient or inpatient setting nationwide. RESULTS On average, men with schizophrenia died 15 years earlier, and women 12 years earlier, than the rest of the population, and this was not accounted for by unnatural deaths. The leading causes were ischemic heart disease and cancer. Despite having twice as many health care system contacts, schizophrenia patients had no increased risk of nonfatal ischemic heart disease or cancer diagnoses, but they had an elevated mortality from ischemic heart disease (adjusted hazard ratio for women, 3.33 [95% CI=2.73-4.05]; for men, 2.20 [95% CI=1.83-2.65]) and cancer (adjusted hazard ratio for women, 1.71 [95% CI=1.38-2.10; for men, 1.44 [95% CI=1.15-1.80]). Among all people who died from ischemic heart disease or cancer, schizophrenia patients were less likely than others to have been diagnosed previously with these conditions (for ischemic heart disease, 26.3% compared with 43.7%; for cancer, 73.9% compared with 82.3%). The association between schizophrenia and mortality was stronger among women and the employed. Lack of antipsychotic treatment was also associated with elevated mortality. CONCLUSIONS Schizophrenia patients had markedly premature mortality, and the leading causes were ischemic heart disease and cancer, which appeared to be underdiagnosed. Preventive interventions should prioritize primary health care tailored to this population, including more effective risk modification and screening for cardiovascular disease and cancer.
Substance Use Disorders and COVID-19: Multi-Faceted Problems Which Require Multi-Pronged Solutions

COVID-19 shocked health and economic systems leaving millions of people without employment and safety nets. The pandemic disproportionately affects people with substance use disorders (SUDs) due to the collision between SUDs and COVID-19. Comorbidities and risk environments for SUDs are likely risk factors for COVID-19. The pandemic, in turn, diminishes resources that people with SUD need for their recovery and well-being. This article presents an interdisciplinary and international perspective on how COVID-19 and the related systemic shock impact on individuals with SUDs directly and indirectly. We highlight a need to understand SUDs as biopsychosocial disorders and use evidence-based policies to destigmatize SUDs. We recommend a suite of multi-sectorial actions and strategies to strengthen, modernize and complement addiction care systems which will become resilient and responsive to future systemic shocks similar to the COVID-19 pandemic.
Filtrage de fonctions de coût globales d écomposables

Les auteurs de [18] ont montr e que les probl emes de satisfaction de contraintes pond er ees peuvent b en e cier de l'introduction des fonctions de co^ut globales, con- duisant au nouveau paradigme de la programmation par fonctions de co^uts. Dans cet article, nous explorons la possibilit e de d ecomposer les fonctions de co^ut globales de sorte qu'appliquer une consistance locale souple sur la d ecomposition produit le m^eme niveau de consistance que sur la fonction de co^ut initiale. Nous donnons des conditions pour lesquelles l'arc consistance directionelle et l'arc consistance virtuelle o rent de telles garanties. Nos exp erimentations, men ees sur des fonctions de co^ut d ecomposables, montrent que les d ecompositions peu- vent ^etre tr es utiles pour int egrer e cacement des fonc- tions de co^ut globales dans des solvers.
Case report: Unintended errors with EHR-based result management: a case series

Test result management is an integral aspect of quality clinical care and a crucial part of the ambulatory medicine workflow. Correct and timely communication of results to a provider is the necessary first step in ambulatory result management and has been identified as a weakness in many paper-based systems. While electronic health records (EHRs) hold promise for improving the reliability of result management, the complexities involved make this a challenging task. Experience with test result management is reported, four new categories of result management errors identified are outlined, and solutions developed during a 2-year deployment of a commercial EHR are described. Recommendations for improving test result management with EHRs are then given.
¿Qué tan “amazónicas” son las lenguas kawapana? Contacto con las lenguas centro-andinas y elementos para un área lingüística intermedia

La familia lingüística kawapana del nororiente peruano está conformada por los idiomas shiwilu y shawi, también conocidos como jebero y chayahuita respectivamente. Por lo común, se suele categorizar a las lenguas kawapana como entidades lingüísticas “amazónicas”. No obstante, el presente estudio demuestra que estas comparten semejanzas gramaticales apreciables con las familias centro-andinas quechua y aimara, así como con otros idiomas de las tierras bajas relativamente cercanos. Dicha convergencia sería el resultado de cambios lingüísticos inducidos por el contactoo la difusión indirecta. Además de develar el complejo perfil gramatical delas lenguas kawapana, el presente estudio proporciona evidencia en favor de un área lingüística intermedia entre la Amazonía y los Andes, de la cual los idiomas kawapana formarían parte.
Enhancement of fracture toughness in nanostructured diamond-SiC composites

We synthesized diamond–SiC nanocomposites with superhardness and greatly enhanced fracture toughness through a synthetic approach based on high-energy ball milling to form amorphous Si precursors followed by rapid reactive sintering at high pressure (P) and high temperature (T). We show how the simultaneous P–T application allows for better control of the reactive sintering of a nanocrystalline SiC matrix in which diamond crystals are embedded. The measured fracture toughness KIC of the synthesized composites has been enhanced greatly, as much as 50% from 8.2 to 12.0 MPa m1/2, as the crystal size of the SiC matrix decreases from 10 μm to 20 nm. Our result contradicts a commonly held belief of an inverse correlation between hardness and fracture toughness. We demonstrate the importance of nanostructure for the enhancement of mechanical properties of the composite materials.
A Symmetry Hypothesis and MeasurementBiases in , the Factor Content ofJ ' hlde

I revisit Reimer (2006), and Trefler and Zhu (2005, 2006) (RTZ) tests of the Vanek proposition in the presence of international differences in production techniques and global production sharing. In this framework, knowing the bilateral details of each country’s input-output structure is key to the correct calculation of the factor content of trade. Because input-output tables typically lack this detail, RTZ impute the relevant input-output coefficients using a method that implicitly assumes that international flows of goods respond to trade determinants independently of their end-use (Symmetry Hypothesis). This paper uses surveybased input-output coefficients from the Asian Input-Output tables (AIO) that do provide bilateral detail. Exploiting methodological differences in the compilation of the AIO tables and the data underlying RTZ studies, I empirically test the symmetry hypothesis and find that it fails. This failure causes input-output data imputed following RTZ methodology to overstate the gross quantity of both domestic and foreign factors’ services embodied in a country’s trade. However, both biases are systematic and tend to cancel each other out resulting in only a small positive bias on net flows of factors and in the performance of the Vanek proposition.
Integração conceptual na descrição de fenômenos gramaticais do português

A Gramatica funcional tem atualmente grande aceitacao nos meios linguisticos, principalmente por ser capaz de esclarecer a motivacao de fatos gramaticais na construcao de um texto. A partir dela, deixa-se a tradicao de estudar a gramatica pela gramatica. Pronomes demonstrativos, por exemplo, passam a ser vistos como ferramentas eficazes de coesao textual, retomando anaforicamente termos de oracoes anteriores. Essa tarefa, contudo, acaba deixando pelo caminho um rastro infindavel de “caixas pretas”. Como explicar a origem do funcionamento anaforico dos demonstrativos, se eles servem originalmente, na lingua falada, para apontar coisas ou pessoas em relacao a posicao espacial dos interlocutores? O objetivo deste trabalho e mostrar que a Linguistica Cognitiva surge justamente como uma opcao de abertura dessas caixas pretas. No presente artigo, escolhi um de seus topicos, a teoria da integracao conceptual (blending) para defender essa possibilidade. Nessa tarefa, achei necessario, em primeiro lugar, integrar o modelo cognitivista dentro da Teoria da Complexidade, de acordo com Bybee (2010) e Castilho (2009), que defendem a linguagem humana como um sistema adaptativo complexo. Depois disso, faco uma breve descricao atualizada da teoria da integracao conceptual e proponho sua aplicacao a alguns fatos gramaticais da lingua portuguesa, no nivel morfologico e sintatico.
Obstructive Tracheal Necrosis in a Dog Secondary to Smoke Inhalation Injury—Case Report

A 4-year-old Siberian Husky mix was referred to the emergency service of the University of California Davis Veterinary Medical Teaching Hospital after being found unconscious in a housefire. Upon arrival, the dog was conscious and panting with normal breathing effort. The dog was initially treated with oxygen therapy to minimize the risk of carbon monoxide toxicosis. Progressive agitation with paroxysmal episodes of increased respiratory effort and increased upper airway sounds were noted ~48 h after presentation. Hypoxemia was then documented. Clinical signs continued to progress despite supportive measures, and five days after initial presentation mechanical ventilation was deemed indicated. Following anesthetic induction, endotracheal intubation was performed. Capnography and peak inspiratory pressures recorded on the mechanical ventilator were consistent with airway obstruction. Diffuse intraluminal tracheal obstruction with grossly necrotic tracheal tissue was confirmed using fiber optic tracheoscopy. The patient was humanely euthanized due to grave prognosis. At necropsy, the tracheal lumen was obstructed by sloughed, necrotic tracheal mucosa. This is the first report describing a severe delayed intrathoracic large airway complication secondary to smoke inhalation in a dog.
How do plants “notice” attack by herbivorous arthropods?

Precise and deep comprehension of plant responses to herbivorous arthropods requires detailed knowledge of how a plant “notices” the attack. Herbivore attack is not restricted to plant wounding by feeding, but instead different phases of attack that elicit a plant response need to be distinguished: touch, oviposition and feeding. Touch, secretions released with eggs and regurgitate delivered during feeding may act in concert as elicitors of plant defence. Here, we discuss the current knowledge of what a plant “notices” during the different phases of herbivore attack and how it responds at the molecular, physiological and ecological level. Understanding the mechanisms of plant responses to the different phases of herbivore attack will be a key challenge in unravelling the complex communication pathways between plants and herbivores.
A simple, versatile, sensitive and volume-independent method for quantitative protein determination which is independent of other external influences.

A method is described which in principle is a quantitative "spot analysis". 0.5-5 microliter of a protein solution in the concentration range between 0.01-10 mg/ml is used for one determination. The sample is taken up by capillary attraction in a 0.5-, 1-, 2- or 5-microliters capillary and transferred to a cellulose acetate strip. The protein is fixed and stained simultaneously by dipping the cellulose acetate strip into a solution of Amido Black or a benzoxanthene derivative (Hoechst 2495) dissolved in in methanol/acetic acid. After elution of the excess of dye (3 x 5 min) the quantitative evaluation can be performed in different ways: 1) The sample is fixed and made transpartent by incubation in dioxane/1-butanol and evaluated densitometrically (Amido Black 10B) or 2) the evaluation is performed in situ by spot fluorometry (Hoechst 2495). 3 The sample can be dissolved together with the acetate layer completely in dioxane, dimethylsulfoxide or N,N-dimethylformamide and evaluated photometrically or 4) fluorometrically. 5) Highest sensitivity is reached if the fluorochrome (Hoechst 2495) bound to the protein is eluted with 15% NH4OH and measured fluorometrically. There is a linear correlation with a correlation coefficient of 0.999 between the fluorescence and a protein amount of 10 ng-20 micrograms. In addition to its simplicity, the method has the advantage of being independent of or well-defined against other external influences, e.g., sodium dodecyl sulfate, mercaptoethanol, Triton X-100, etc. The stainability of a protein with Amido Black is influenced stoichiometrically by sodium dodecyl sulfate (not by mercaptoethanol) whilst the staining with Hoechst 2495 is not at all affected. As there is linear correlation between the area of a spot on an acetate layer and the volume applied in the range between 0.5 and 5 microliters, (only influenced stoichiometrically by the protein concentration in that volume, which in turn is measured by staining with Amido Black), then with a simple iterative calculation on the basis of suitable calibration curves, it is easily possible to determine a protein concentration in mg/ml even in an unknown volume between 0.5 and 5 microliters.
Angiotensin II Type 1 Receptor Blocker, Valsartan, Prevented Cardiac Fibrosis in Rat Cardiomyopathy after Autoimmune Myocarditis

Summary: Favorable effects of angiotensin II type 1 receptor blockers on patients with ischemic or idiopathic dilated cardiomyopathy have already been suggested by several human trials but their effects on inflammatory cardiomyopathy remain unknown. We investigated the effects of the angiotensin II type 1 receptor blocker, valsartan, in chronic heart failure after inflammatory cardiomyopathy. Autoimmune myocarditis was induced in Lewis rats by injection with porcine cardiac myosin. In the phase of chronic heart failure, from day 28 until day 70, rats were treated by oral administration of valsartan. Three groups were designated: 1 ml saline, 10 mg/kg valsartan, and 30 mg/kg valsartan. On the 73rd day, hemodynamic parameters, pathological findings and the expression levels of r‐ANP mRNA of the ventricle were examined, and were compared with the saline control. The ventricular weight/body weight ratio and area of fibrosis was decreased in the 30 mg/kg valsartan group. The left ventricular end‐diastolic pressure and the central venous pressure were decreased in a dosedependent manner in both valsartan groups, while the first pressure derivatives +dP/dt and ‐dP/dt did not differ among the three groups. A high dose of valsartan reduced the expression of tissue ANP mRNA compared with the saline group. In conclusion, valsartan suppressed myocardial hypertrophy and fibrosis, and it improved the hemodynamics and cardiac function in an animal model of post‐myocarditis dilated cardiomyopathy.
Comparison of Internet Usage Habits in Two Generations of Higher Education Students - A Case Study

Final Remarks IPP’s students profile usage of Internet Internet is accessed 1 to 3 hours a day; Email and synchronous communication are the tools used daily; this last one, is more frequently used among the younger students Internet is primarily used to search information, access Moodle eLearning platform, exchange emails, and to talk with friends Most students have, at least, profile at one social network, and 33% usually meet new people through these platforms LMS’s platform students usage (Moodle as 98% coverage in IPP) Daily accessed; Students find no difficulties in the use of Moodle and think this LMS is an important tool in their learning process Web 2.0 tools (wikis, forums or blogs) are scarcely used by teachers Future research Replicate this study every 2 years, and use these data as an Internet Usage Observatory To study Internet’s usage habits of all IPP’s population and establish orientation guidelines to a successful exploit of Internet technologies in the Higher Education learning process (These tools are, statistically more used by students born after 1980: Instant messaging (p≅0,000), Social networks (p≅0,000), Forums (p=0,009) and Games (p≅0,000) use). Comparison of Internet Usage Habits in Two Generations of Higher Education Students. A Case Study
Movement and distribution of house flies (Diptera: Muscidae) between habitats in two livestock farms.

House fly, Musca domestica L. , movement between breeding sites (dairies and poultry houses) and into surrounding habitats (buildings, fields, and pastures) was measured by releasing marked flies in poultry houses and dairies at two farms. Relative density of wild and marked flies was greater in the dairy and poultry houses than in other habitats at similar distances from the release areas. Calculated proportions of wild flies in each habitat were greatest in the dairies and poultry houses; averages of 25 and 36% of the wild populations were estimated to be in the other habitats. After 5 days, an average of 60 and 53% of marked flies released in the poultry houses remained there, 13% moved to the dairies at both farms, and 27 and 34% moved from the poultry houses to the non breeding habitats. An average of 56 and 73% of the marked flies released in the dairies remained there after 5 days, while 8 and 10% moved into the poultry houses, and 34 and 19% moved from the dairies into the nonbreeding habitats at both farms.
Diabetic retinopathy analysis using CDR technique

Diabetes has become one of the rapidly increasing health threats worldwide. Diabetes occurs when the pancreas fails to secrete enough insulin, slowly affecting the retina of the human eye. As it progresses, the vision of a patient starts deteriorating, leading to diabetic retinopathy. The diabetic retinopathy is a micro vascular complication of diabetes, causing abnormalities in the retina, and in the worst case, blindness. Typically there are no salient symptoms in the early stages of diabetic retinopathy, but their number and severity predominantly increase with time. The early stage detection of diabetic retinopathy should be done. As detection appears in the early stage the level of the disease can be observed. The hardware developed will help to detect the level of DR. The implementation will be done using fundus images of retina of diabetic retinopathy patient. Preprocessing is done on image and level will be detected along it. Earlier the detection is done by taking the images and processing can be done on it. The project helps provide different stages of diabetic retinopathy, so as to cure it and diagnose it.
BMPs, FGF8 and Wnts regulate the differentiation of locus coeruleus noradrenergic neuronal precursors

In the present study, we investigated the involvement of rhombomere 1 patterning proteins in the regulation of the major noradrenergic centre of the brain, the locus coeruleus. Primary cultures of rat embryonic day 13.5 locus coeruleus were treated with fibroblast growth factor‐8, noggin and members of the bone morphogenetic and Wnt protein families. We show that bone morphogenetic proteins 2, 5 and 7 increase and noggin decreases the number of tyrosine hydroxylase‐positive locus coeruleus neurons. Interestingly, from all Wnts expressed in the first rhombomere by embryonic day 12.5 in the mice, we only found expression of wnt5a mRNA in the vicinity of the locus coeruleus. In agreement with this finding, from all Wnts studied in vitro, only Wnt5a increased the number of tyrosine hydroxylase‐positive neurons in locus coeruleus cultures. Finally, we also found that fibroblast growth factor‐8 increased the number of tyrosine hydroxylase‐positive cells in locus coeruleus cultures. Neither of the identified factors affected the survival of tyrosine hydroxylase‐positive locus coeruleus noradrenergic neurons or the proliferation of their progenitors or neurogenesis. Instead, our results suggest that these patterning signals of rhombomere 1 may work to promote the differentiation of noradrenergic progenitors at later stages of development.
La théorisation de la pratique

Une reflexion prealable situe la didactique et definit le role du didacticien. Cette reflexion permet de montrer comment les parametres de l’enseignement et de l’apprentissage ont ete determines et comment leur operationnalite pratique a ete mesuree aupres des enseignants. L’attention se porte ensuite sur le jeu des parametres de l’apprentissage, en particulier par une modelisation du passage de l’input a l’output qui tente de prendre en compte l’ensemble des parametres releves. L’influence des parametres de l’enseignement sur ce modele est evidente, mais, comme la hierarchie des priorites, elle est encore imparfaitement determinee. La conclusion rappelle que l’ensemble de la reflexion, comme les conclusions de recherches dans les sciences de fondement, reste largement hypothetique et donc sujette a evolution.
A Novel Compact Ultrawideband Antenna

In this paper, novel compact ultrawideband (UWB) antennas are proposed and successfully demonstrated within the bandwidth with the ratio of the maximum and minimum frequency to be more than 30. The results from electromagnetics (EM) simulation and measurement show good agreement. From the EM simulation results, the electromagnetic wave could be radiated to the free space through the antenna only if the antenna impedance were matched to one of its feed systems within the bandwidth. The developed antenna with a small size of 17times17times12 mm3 shows voltage standing wave ratio (VSWR) of less than 2.5 : 1 from 3 to 100 GHz for the simulated data, and less than 2:1 from 3 to 50 GHz for the measured data. The gain of the developed antenna is more than 2 dBi from 3.1 to 10.6 GHz in the application of high-speed wireless digital communication system.