Miracle-dz/UniFAR-FTUs huggingface dataset:
Antijam Performance of Fast Frequency-Hopped M-ary NCFSK-An Overview

The antijam performance of M -ary noncoherent FSK with fast frequency hopping (one or more hops per symbol) is studied. A summary of terminology, definitions, and an overview of the literature is given. A general analysis method based upon circularly symmetric signal theory is presented. It provides a means for exact analysis of performance for M -ary operation with any combination of signal tone distribution (frequency bins contiguously or noncontiguously spaced), jamming distribution, jamming form (partial-band noise or multitone), and receiver system noise. Some previous results are derived as subcases of the general theory. A simple robust diversity combining technique of transmitting a symbol on L hops followed by a majority vote decision is found to provide significant performance improvements. This improvement is comparable to that obtained by most error-correction coding methods. Illustrative calculations of performance were chosen to indicate trends rather than to be exhaustive. Performance is usually presented as probability of bit error versus fraction of the band jammed to emphasize worst-case operation.
Model selection through a statistical analysis of the global minimum of a weighted nonlinear least squares cost function

This paper presents a model selection algorithm for the identification of parametric models that are linear in the measurements. It is based on the mean and variance expressions of the global minimum of a weighted nonlinear least squares cost function. The method requires the knowledge of the noise covariance matrix but does not assume that the true model belongs to the model set. Unlike the traditional order estimation methods available in literature, the presented technique allows to detect undermodeling. The theory is illustrated by simulations on signal modeling and system identification problems and by one real measurement example.
An Epigenetics-Based, Lifestyle Medicine–Driven Approach to Stress Management for Primary Patient Care: Implications for Medical Education

Over 75% of patients in the primary care setting present with stress-related complaints. Curiously, patients and health care providers all too often see stress as a relatively benign sequela of many common illnesses such as heart disease, cancer, lung disease, dementia, diabetes, and mental illness. Unfortunately, various day-to-day lifestyle choices and environmental factors, unrelated to the presence of any disease, can cause stress sufficient to contribute to the development of various diseases/disorders and suboptimal health. There is evidence suggesting that counseling in stress management–oriented therapeutic interventions (as offered by lifestyle medicine–oriented practitioners) may prevent or reduce the onset, severity, duration, and/or overall burden of stress-related illnesses. Such counseling often involves considerations such as the patient’s nutrition, physical activity, interest in/capacity to meditate, drug abuse/cessation, and so on. Unfortunately, lifestyle medicine–oriented approaches to stress management are rarely offered in primary care—the patient care arena wherein such counseling would likely be best received by patients. Would health care outcomes improve if primary care providers offered counseling in both stress management and positive lifestyle choices? The purpose of this article is to provide both primary care practitioners and educators in health care training programs with an introductory overview of epigenetics. An emerging field of science offering insights into how factors such as stress and lifestyle choices interact with our genes in ways that can both positively and negatively impact the various micro (eg, cellular) through macro (eg, physiologic, pathophysiologic) processes that determine our tendencies toward illness or wellness. A deeper understanding of epigenetics, as provided herein, should enable primary care providers and medical educators to more confidently advocate for the primary benefits associated with counseling in both stress reduction and the pursuit of healthy lifestyle choices.
Fractional radiofrequency treatment in acne scars: Systematic review of current evidence

Fractional radiofrequency (FRF) is renowned for its use in cosmetic dermatology, with regard to the treatment of rhytides, striae, scarring and cellulite. We have systemically analysed its evidence for the use of FRF in acne scars. Our search identified 15 articles, one single-blinded randomised controlled trial, two split-face trials and thirteen prospective clinical studies, mostly single-centred. Case reports were excluded. In total 362 patients were treated. The longest follow-up was for 210 days, and on average the follow-up was for three months, varying between one and seven months. This review has found that there are many small studies showing promising results for the use of FRF in acne scars, either as an adjunct or more importantly as the sole treatment. There is however a need for larger trials against ablative and non-ablative lasers, in order to affirm the evidence present already. This is the first systematic review on the use of FRF in acne scars.
Reading source code

Source code is, among other things, a text to be read. In this paper I argue that reading source code is a key activity in software maintenance, and that we can profitably apply experiences and reading systems from text databases to the problem of reading source code. Three prototype systems are presented, and the main features of their design are discussed.
Building envelope renovation for net zero energy building in hot humid climate

Net Zero Energy building has become a topic that has drawn much attention from architects worldwide. Its concept is that buildings can meet all of their energy requirements from renewable sources. In Thailand, the renewable energy that is most suitable for integration into the idea of net zero energy building is photovoltiacs. With government funding, the communication affairs division building, Khon Kaen University, is selected for the renovation existing building to be net zero energy building. It is successfully proved that, after one year record, the energy produces by the PVs, 22,944 kWh is more than energy consumption, 20,932 kWh. This paper focuses on envelope renovation because it is an important part of the building that can apply to other renovation project in the future. It found that the envelope renovation for Net Zero Energy Building can be separated to be two part, for energy saving and for renewable energy installation. For photovoltaic installation, it can simply install on the metal sheet roof by using metal frame with special clip. The research and renovation on the envelope from this project can apply for the future net zero energy building in Thailand.
Involvement of sulfated glycosaminoglycans on the development and attachment of Trypanosoma cruzi to the luminal midgut surface in the vector, Rhodnius prolixus

SUMMARY In the present study, we investigated the involvement of sulfated glycosaminoglycans in both the in vivo development and adhesion of T. cruzi epimastigotes to the luminal surface of the digestive tract of the insect vector, Rhodnius prolixus. Pre-incubation of T. cruzi, Dm 28c epimastigotes with heparin, chondroitin 4-sulfate, chondroitin 6-sulfate or protamine chloridrate inhibited in vitro attachment of parasites to the insect midgut. Enzymatic removal of heparan sulfate moieties by heparinase I or of chondroitin sulfate moieties by chondroitinase AC from the insect posterior midgut abolished epimastigote attachment in vitro. These treatments also reduced the labelling of anionic sites exposed at the luminal surface of the perimicrovillar membranes in the triatomine midgut epithelial cells. Inclusion of chondroitin 4-sulfate or chondroitin 6-sulfate and to a lesser extent, heparin, in the T. cruzi-infected bloodmeal inhibited the establishment of parasites in R. prolixus. These observations indicate that sulfated glycosaminoglycans are one of the determinants for both adhesion of the T. cruzi epimastigotes to the posterior midgut epithelial cells of the triatomine and the parasite infection in the insect vector, R. prolixus.
Solar PV inverter testing for model validation

This paper will cover the solar PV inverter tests required for model development and validation including but not limited to voltage transients, frequency deviations, grid disconnection, short circuit, harmonics generation, and voltage oscillations. Additionally, it will cover the test results acquired from our tests of 3-phase 480VAC commercial solar PV inverters. Finally, it will cover proposed recommendations for solar PV inverter performance to accommodate high penetration of solar PV inverter generation.
Lamotrigine: clinical experience in 93 patients with epilepsy

This open study reports the use of lamotrigine in 93 adults and children with drug resistant epilepsy. Lamotrigine was used predominantly as add‐on therapy and outcome was assessed by the patient, parents and carers and the physician in terms of reduction of seizure frequency, drug side effects, and importantly with this drug, improvement in quality of life. Twenty five of the 93 patients (26.9%) studied were rendered seizure free with the addition of lamotrigine to their therapy. This was especially the case for patients with complex partial seizures, generalised seizures secondary to brain damage, primary generalised epilepsy and the Lennox Gastaut syndrome. Quality of life improvements were especially striking in patients with seizures secondary to brain damage and in the Lennox Gastaut Syndrome. Twenty eight patients ceased lamotrigine, 13 due to lack of effect and the remainder due to side effects. Lamotrigine is a potentially very useful anti‐epileptic medication in persons with complex partial seizures, but also in primary generalised epilepsy, the Lennox Gastaut syndrome and especially in those individuals who have seizures subsequent to brain damage.
Lexical and grammatical development in a child with cochlear implant and attention deficit: A case study

This is the first study to explore lexical and grammatical development in a deaf child diagnosed with Attention Deficit Hyperactivity Disorder, Inattentive sub-type (ADHD/I). The child, whose family language was Spanish, was fitted with a cochlear implant (CI) when she was 18 months old. ADHD/I, for which she was prescribed medication, was diagnosed 3;6 years later. Speech samples were videotaped over the first 4 years of CI use and during a follow-up session 1 year later. Samples were transcribed according to CHAT conventions and several measures of expressive language were obtained. Receptive language was evaluated with standardized tests. Results show that while some aspects of her development seemed relatively positive (e.g., acquisition of verbal morphemes at the same auditory age as typical children), other characteristics were atypical for a CI user: (1) preference for paralexical expressions in early lexicon; (2) lexical errors in colours and other abstract words; and (3) low MLU and varied grammatical errors including disorganized discourse. Medication had a positive effect on all these characteristics, providing evidence of a link with ADHD/I. This study concludes that ADHD/I had a direct impact on the lexical and grammatical development in this child, as well as an indirect influence over her communicative style. More studies are needed to explore language characteristics of children with CI and ADHD.
Analysis of Gene‐Gene Interactions

The goal of this unit is to introduce epistasis, or gene‐gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene‐gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta‐analysis, replication, and other topics of active research. © 2017 by John Wiley & Sons, Inc.
Study of the mechanisms regulating human umbilical artery contractility

We studied the involvement of different types of Ca2+ channels, cyclic nucleotides and different kinases in the regulation of human umbilical artery (HUA) contractility. The elucidation of the precise mechanisms regulating the contractility of this artery could be very important to reveal potential therapeutic targets to treat HUA disorders such as preeclampsia. The relevancy of different types of Ca2+ channels on the regulation of HUA tonus was analyzed. Among the different Ca2+ channel inhibitors used, only the L-type calcium channels (LTCC) inhibition induced relaxation of HUA in Ca2+ containing medium. The inhibition of T-type calcium channels (TTCC) or TRP channels did not significantly affect HUA contractility. In presence of Ca2+, the intracellular increase of a cyclic nucleotide (cAMP or cGMP) induces relaxation of HUA, which was almost complete in histamine-con- tracted HUA, and lower effect was observed in arteries contracted by KCl and serotonin (5-HT). Inhibition of PKA and PKG weakly reduced the relaxations induced by the increase of cAMP and cGMP respectively, suggesting that the relaxation induced by these nucleotides is not totally mediated by the activation of their respective kinases and that other mechanisms are involved. In calcium containing solution, PP2A inhibition produces relaxation of contracted HUA. In KCl contracted arteries, the OA and nifedipine relaxant effects are similar and not additive, suggesting that PP2A could activate LTCC. Besides, the increase of cyclic nucleotides significantly increased the OA effect, suggesting that the effect of PP2A inhibition is independent of the cyclic nucleotide pathways. The contractions induced by KCl, histamine and 5-HT in presence of Ca2+ were not significantly affected by ROCK, ERK1/2 or p38MAPK inhibitors. In absence of extracellular Ca2+, histamine and 5-HT elicited contractions of HUA characterized by two components, a rapid phasic contractile component followed by a decrease of the contraction until a tonic component. However, KCl elicited sustained contractions of HUA in absence of extracellular Ca2+. As in presence of calcium, the ERK1/2 and p38MAPK inhibitors did not influence the contractions induced by KCl, histamine or 5-HT in absence of extracellular Ca2+. However, in these conditions, ROCK inhibition significantly relaxed the contractions induced by KCl and reduced the phasic and tonic components of the contraction elicited either by histamine or 5-HT. Our results show that calcium-dependent contractions of HUA depend on Ca2+ entry by LTCC, and these chan- nels seems to be positive regulated by PP2A. Cyclic nucleotides mediate HUA vasodilatation but their dependent kinases are not the unique responsible of this effect. HUA is able to contract independently of Ca2+ influx by activating the ROCK pathway and/or due to intracellular Ca2+ release.
Face Recognition System based on SURF and LDA Technique

In the past decade, Improve the quality in face recognition system is a challenge. It is a challenging problem and widely studied in the different type of imag- es to provide the best quality of faces in real life. These problems come due to illumination and pose effect due to light in gradient features. The improvement and optimi- zation of human face recognition and detection is an im- portant problem in the real life that can be handles to optimize the error rate, accuracy, peak signal to noise ratio, mean square error, and structural similarity Index. Now-a-days, there several methods are proposed to recognition face in different problem to optimize above parameters. There occur many invariant changes in hu- man faces due to the illumination and pose variations. In this paper we proposed a novel method in face recogni- tion to improve the quality parameters using speed up robust feature and linear discriminant analysis for opti- mize result. SURF is used for feature matching. In this paper, we use linear discriminant analysis for the edge dimensions reduction to live faces from our data-sets. The proposed method shows the better result as compare to the previous result on the basis of comparative analysis because our method show the better quality and better results in live images of face.
Dynamic Switching of Total-Order Broadcast Protocols

The exchange of total order broadcast protocols for dependable applications has been already studied and solved in several previous papers. To this end, some switching mechanism is needed. All these solutions have been inspired in a two-phase algorithm. The first phase is needed to agree on the need of change, stopping then the old protocol. Whilst the second one is needed to wait for the delivery of all previously broadcast messages, allowing to start later with the new protocol. This introduces a blocking interval that could be quite long in networks with high latency (e.g., WANs) or in systems with slow (i.e., heavily loaded) processes. We propose a new switching mechanism that avoids all such inconveniences, ensuring a fast migration between different broadcast protocols.
FLT3 mutations do not influence MDR-1 gene expression in acute myeloid leukemia.

BACKGROUND A worse outcome for patients carrying FLT3 mutations or expressing MDR1 gene has been reported. This study was designed to verify the possible co-expression of mutated-FLT3 and MDR1 genes and to evaluate their independent prognostic role. PATIENTS AND METHODS Sixty-one AML patients were tested for MDR1-mRNA levels by real-time PCR and for FLT3 mutations by PCR and Genescan analysis. RESULTS FLT3 mutations were detected in 31% of patients, more frequently in patients < 60 years and at standard cytogenetic risk. Among 92% of patients MDR1-positive, 50% expressed high levels of mRNA. No significant correlation was found between FLT3 mutations and high levels of MDR1. FLT3 or MDR1 mutations failed to show any role concerning the CR achievement and OS. On the contrary, a significant disadvantage for DFS was found in the group of patients carrying FLT3/ITD. CONCLUSION The results reported above show that FLT3 mutations and MDR1 expression represent two independent clinical prognostic factors for AML patients.
Nonlinear filtering for Power Quality disturbances analysis

In this work, a new method for PQ analysis is proposed based on the use of neural processing aiming to decouple the information from different disturbances from the power system signal. The system was implemented and tested using a simulated database showing the good performance of the proposed technique for signal separation. It was shown that the proposed method could also be used as a preprocessing technique for PQ monitoring systems.
Patients who present to the emergency department and leave without being seen: prevalence, predictors and outcomes

Objective To identify the prevalence, predictors and outcomes of patients who leave without being seen (LWBS) in one hospital emergency department (ED). Materials and methods A descriptive, retrospective cohort study design was used. Data were extracted from the ED Information System. Multivariate logistic regression identified independent predictors of patients who LWBS. Two main outcomes were studied: the proportion of patients who waited longer than recommended and the proportion of patients who represented to the ED within 72 h. Setting A large regional teaching hospital ED in South East Queensland, Australia. Sample A total of 64 292 patient presentations made to the ED from 9 August 2008 to 8 August 2009. Results The prevalence of patients who LWBS was 10.7%. Independent predictors of LWBS included younger age, lower urgency triage category allocation, arrival by means other than ambulance, evening and night shift presentations, winter season, weekend presentations and presenting complaint category of ‘gastrointestinal’ or ‘paediatric’. When compared with patients who waited, those who LWBS comprised higher proportions of waiting longer than recommended (LWBS: 77.2% vs. waited: 52.0%, P<0.001) and higher proportions of representations to ED within 72 h (LWBS: 10.3% vs. waited: 5.4%, P<0.001). Conclusion Outcomes investigated in this study indicate that room for improvement exists not only for patients who LWBS but all patients presenting to the ED. The most powerful predictors of LWBS were lower urgency triage allocation and evening and night shift presentations. This suggests that service improvements could be targeted during ‘out of business hours’ for those with less emergent conditions.
Effect of Alendronate on Bone Mineral Density in Post Menopausal Women with Type 2 Diabetes Mellitus

Aim: To perform a retrospective study to determine the effect of Bisphophanates on bone mineral density (BMD) in the late post-menopausal (PM) osteoporatic and osteopenic women with Type 2 Diabetes Mellitus (DM). Method: In this retrospective case control study, 114 PM diabetic women over age 65 who took alendronate for at least 3 years, 43 of them had osteoporosis and 71 with osteopenia. The efficacy of therapy was measured by comparing a minimum of two BMD studies. Result: The study (n=114) demonstrated statistically significant BMD gain (+3.1% and +1.9%) at the spine and hip respectively but statistically significant loss of BMD (-9.8%) at forearm (FA). There was statistically significant correlation between body mass index (BMI) and BMD, in spine and hip but not in FA. We found negative correlation between A1C and BMD at all 3 sites, with a statically significant correlation observed at FA. Conclusion: It appears that Bisphosphonates are not effective in preventing bone loss in the FA of diabetic post-menopausal women. In addition bisphosphonates therapy resulted in significant gains of BMD at the spine and hip. A larger study should be done to compare bisphosphonates to other modalities of therapy for osteoporosis in diabetic post menopausal patients.
Low serum cholesterol. Hazardous to health?

Is having very low cholesterol levels hazardous to health? There is evidence to suggest that it might be. In 1990, an NIH conference concluded from a meta-analysis of 19 studies that men and, to a lesser extent, women with a total serum cholesterol level below 4.2 mmol/L (160 mg/dL) (6th percentile) exhibited about a 10% to 20% excess total mortality compared with those with a cholesterol level between 4.2 and 5.2 mmol/L (160 to 199 mg/dL). 1 Specifically, excess causes of death included cancer (primarily lung and hematopoietic), respiratory and digestive disease, violent death (suicide and trauma), and hemorrhagic stroke. On the basis of this and other reports, a debate arose on whether recommendations for lowering cholesterol should be directed at the entire population or only toward those at high risk of coronary heart disease. Would shifting the entire cholesterol distribution downward subject those individuals at the low end of the scale to increased risk of noncardiovascular disease? 2 3 A major obstacle to finding an answer to this question has been that the determinants of low cholesterol are poorly understood. Why does someone living in a westernized country have a very low serum cholesterol concentration? Apart from consuming an “atypical” very-low-fat, low-cholesterol diet, the reasons include “genetic resistance” to excess dietary cholesterol,4 an underlying condition causing hypocholesterolemia …