Miracle-dz/UniFAR-FTUs huggingface dataset:
RNA-SEQ: A GLANCE AT TECHNOLOGIES AND METHODOLOGIES

RNA Sequencing (RNA-Seq) is a newly born tool that has revolutionized the post-genomic era. The data produced by RNA-Seq, sequencing technologies and use of bioinformatics are exploding rapidly. In recent years, RNA-Seq has been the method of choice for profiling dynamic transcriptome taking advantage of high throughput sequencing technologies. RNA-Seq studies have shown the transcriptome magnitude, notion and complexity. From 2008, as its introduction year, the relevant reports on RNA-Seq have been multiplied by more than 2822 times just in 6 years. RNA-Seq also contributes a more accurate gene expression and transcript isoform estimation than other methods. Furthermore, some of the potential applications for RNA-Seq cannot be conducted by other methods and as yet are unique to RNA-Seq. As RNA-Seq approaches increase in speed and decrease in cost, more distinct researches are applied and become more common and accurate. RNA-Seq is a cross and interdisciplinary method that interconnects biology to other scientific topics. This article describes RNA-Seq approach, technologies, methodologies, implementation and methods done so far in characterizing and profiling transcriptomes. RESUMEN En los ultimos anos, la tecnica RNA-Seq ha tenido un desarrollo acelerado y se ha convertido en el metodo de eleccion para el estudio y la caracterizacion de los transcriptomas dinamicos, aprovechando las tecnologias de secuenciacion de alto rendimiento. Estudios aplicando RNA-Seq han mostrado la magnitud, nocion y complejidad del transcripotma. A partir de 2008, ano de introduccion de la tecnica, los estudios con RNA-Seq se han multiplicados por mas de 2822 veces solo en 6 anos. Al compararse con otros metodos, los estudios empleando RNA-Seq contribuyen a una estimacion mas precisa de la expresion genica y de las isoformas de los transcriptos. Ademas, algunas de las aplicaciones potenciales de RNA-Seq no se pueden llevar a cabo con otros metodos. El uso de RNA-Seq aumenta la velocidad de obtencion de informacion y disminuye los costos, logrando con su uso, que investigaciones diversas se vuelvan mas frecuentes y precisas. RNA-Seq es un metodo interdisciplinario que interconecta la biologia a otros temas cientificos. En este articulo se describe el planteamiento de la tecnologia RNA-Seq, metodologias y los metodos realizados en la caracterizacion de transcriptomas.
A PID Inspired Feature Extraction for HVAC Terminal Units

Retrofitting older buildings and embedding new building stock with Energy Management Systems (BEMS) is paving the way for smarter energy use and increased wellbeing awareness and initiatives for occupants. BEMS can discover problems related to energy wastage, user comfort and building maintenance. Remote analysis and categorization of the different Heating, Ventilation and Air-Conditioning (HVAC) Terminal Unit (TU) behaviours based on a unique set of features using BEMS data is the main aim of the proposed work. Hence, a novel feature extraction method inspired by the Proportional Integral Derivative (PID) controller response curve to define events from TU data is proposed and applied to multidimensional, realtime data streams remotely retrieved from a building based in the city of London. The feature extraction method executing across different TUs and the feature sets obtained, have been used to identify different TU behaviour patterns. Subsequently, unsupervised machine learning has been employed to investigate automated TU fault detection and diagnosis
Urban Attributes and Regional Differences in Productivity: Evidence from the External Economics of Brazilian Micro-regions from 2000 - 2010

This study aims to identify the extent to which the local productive structure of a city leverages external economies of scale. Formal employment data is grouped into segments according to its level of technological intensity. The model is estimated using panel data. The results suggest evidences of local externalities like location/MAR and urbanization/Jacobs. The results also indicate that the Medium-High- and High-Technology industry segments have advantages only in diversified urban centers, while the Low- and Medium-Low-Technology industries have more advantages in intermediate-sized urban centers, specialized in few industrial activities.
CAREER ASPIRATIONS: AN INVESTIGATION OF SENIOR SECONDARY SCHOOL STUDENTS AWARENESS OF CONTEMPORARY HIGH PROFILE CAREERS

Many students are fond of naming the seemingly common and popular careers such as medicine, engineering and law as their future ambitions. The aim of this study is to determine the level of awareness of the relatively new and contemporary careers which offer bounteous prospects in the modern globalised world by Nigerian adolescents. It is a descriptive study in form of a survey in which questionnaires were used to collect data from a randomly selected sample of senior secondary school students in Ogun State. Appropriate research questions and null hypotheses were raised and tested at 0.05 level. Findings revealed that participants have low level of awareness of contemporary careers. This trend was the same among male and female, rural and urban students. Therefore, it was recommended that career education focusing on contemporary careers should be organized for students from time to time in order to raise their level of career awareness and create ample career opportunities for them in the modern globalised world.
Assessment of Cyclic Resistance Ratio (CRR) in Silty Sands Using Artificial Neural Networks

In this study, a backpropagation neural network algorithm was developed in order to predict the liquefaction cyclic resistance ratio (CRR) of sand-silt mixtures. A database, consisting sufficient published data of laboratory cyclic triaxial, torsional shear and simple shear tests results, was collected and utilized in the ANN model. Several ANN models were developed with different sets of input parameters in order to determine the model with best performance and preciseness. It has been illustrated that the proposed ANN model can predict the measured CRR of the different data set which was not incorporated in the developing phase of the model with the good degree of accuracy. The subsequent sensitivity analysis was performed to compare the effect of each parameter in the model with the laboratory test results. At the end, the participation or relative importance of each parameter in the ANN model was obtained.
Academic Achievement: It Is Not How Smart You Are, But How You Cope With Your Life And Manage Your Time

Previous research suggests that contributing factors such as previous academic result, coping and time management can predict student success at the universities. The purpose of this study was to investigate the relationship between previous academic grades, coping and time management practices on academic achievement among undergraduate students from four of Malaysia public institutions for higher education. 551 university students completed a Time Management Questionnaire (TMQ), COPE Inventory and provided their self-reported high school grades and current Grade Point Average (GPA). Analysis of data from descriptive and inferential statistics was done. Results showed that previous academic grades and the practice of time management (short range planning and attitude toward time) have no direct effect on academic achievement. However, the use of coping strategies (problem focused and denial focused) and the practice of time management (long range planning) showed that there was a significant effect on Grade Point Average (GPA).
Dynamics of a Fractional Order Eco-Epidemiological Model

In this paper, we propose a fractional order eco-epidemiological model. We considere the existence of time memory in the growth rate of the three populations. We observed the dynamical behaviour by analysing with fractional order and then simulateing using Grunwald-Letnikov approximation to support analytical results. It found that the model has five equilibrium points, namely the origin, the survival of susceptible prey, the predator free equilibria, the infected prey free equilibria, the interior equilibria. Numerical simulations show that the existence of fractional order is a factor which affects the behaviour of solutions.
' s personal copy Extinction debt or habitat change ? – Ongoing losses of woodland birds in north-eastern New South Wales , Australia

The loss, fragmentation and degradation of native vegetation are major causes of loss of biodiversity globally. Extinction debt is the term used to describe the ongoing loss of species from fragmented landscapes long after the original loss and fragmentation of habitat. However, losses may also result from habitat changes that are unrelated to fragmentation, which reduce breeding success and recruitment. Many woodland birds have declined in fragmented landscapes in Australia, probably due to loss of small, isolated populations, though the ecological processes are poorly understood. We record the progressive regional loss of two ground-foraging, woodland birds, the Brown Treecreeper Climacteris picumnus and Hooded Robin Melanodryas cucullata, in northern New South Wales, over 30 years. This has happened despite most habitat loss occurring over 100 years ago, suggesting the payment of an extinction debt. Our observations suggest that several ecological processes, caused by habitat loss, fragmentation or degradation, and operating over different time scales, have led to both species’ declines. Female Brown Treecreepers disperse poorly among vegetation remnants, leaving only males in isolated populations, which then go extinct. In contrast, Hooded Robins suffer high nest predation in fragmented landscapes, producing too few recruits to replace adult mortality. Foraging by both species may also be affected by regrowth of ground vegetation and shrubs. We found little support for a major role played by drought, climate change or aggressive Noisy Miners Manorina melanocephala. We propose that both extinction debt in the classical sense and ongoing habitat change frequently contribute to species’ decline in modified landscapes. Management to arrest and reverse such declines needs to consider these multiple causes of decline. For instance, reconnecting isolated populations may be inadequate alone, and activities such as appropriate grazing, fires and the addition of woody debris may also be required. 2009 Elsevier Ltd. All rights reserved.
Advanced Water Distribution Modeling and Management

Peer Review Board Lee Cesario (Denver Water), Robert M. Clark (U.S. EPA), Jack Dangermond (ESRI), Allen L. Davis (CH2M Hill), Paul DeBarry (Borton-Lawson), Frank DeFazio (Franklin G. DeFazio Corp.), Kevin Finnan (Bristol Babcock), Wayne Hartell (Bentley Systems), Brian Hoefer (ESRI), Bassam Kassab (Santa Clara Valley Water District), James W. Male (University of Portland), William M. Richards (WMR Engineering), Zheng Wu (Bentley Systems ), and E. Benjamin Wylie (University of Michigan)
Working with quality from a systems perspective - a case study at Scandstick AB

Scandstick AB is a laminator in the label industry. The company is in an expanding phase, characterized by large investments and organizational changes. The introduction of new machinery has resulted in a backlog and a declining product quality, due to an increased amount of shipped goods. This procedure has resulted in an increased number of customer complaints that demands a significant amount of the company’s resources.
Computationally efficient simultaneous policy update algorithm for nonlinear H∞ state feedback control with Galerkin's method

The main bottleneck for the application of H∞ control theory on practical nonlinear systems is the need to solve the Hamilton–Jacobi–Isaacs (HJI) equation. The HJI equation is a nonlinear partial differential equation (PDE) that has proven to be impossible to solve analytically, even the approximate solution is still difficult to obtain. In this paper, we propose a simultaneous policy update algorithm (SPUA), in which the nonlinear HJI equation is solved by iteratively solving a sequence of Lyapunov function equations that are linear PDEs. By constructing a fixed point equation, the convergence of the SPUA is established rigorously by proving that it is essentially a Newton's iteration method for finding the fixed point. Subsequently, a computationally efficient SPUA (CESPUA) based on Galerkin's method, is developed to solve Lyapunov function equations in each iterative step of SPUA. The CESPUA is simple for implementation because only one iterative loop is included. Through the simulation studies on three examples, the results demonstrate that the proposed CESPUA is valid and efficient. Copyright © 2012 John Wiley & Sons, Ltd.
Improved ALPR system based on Smart License Plate Character Detection Algorithm

: This paper presents improved Automated License Plate Recognition (ALPR) system based on Smart License Plate Character Detection algorithm, this system is capable of distinguishing license plates under various conditions, such as distance from the camera, rotation angle between camera and vehicle and poor illumination condition (different weather condition, different lighting condition and physical tilted or damage of license plate). In our method, improved ALPR system has three main steps: 1) Image Enhancement, 2) Character Segmentation (Smart License Plate Character Detection), 3) Character Recognition. While in regular ALPR system there are four main steps: 1) Image Enhancement, 2) License Plate Location Extraction 3) Character Segmentation, 4) Character Recognition. In image enhancement introduce Multi-Scale Adaptive NICK thresholding method [1] to achieve all objects as character candidates in the binary image; otherwise we might lose license plate characters in an input image due to complex backgrounds. Single Pass Connected Component Labelling (CCL), put the label on detected objects then new design algorithm called “Smart License Plate Character Detection” finds the license plate characters regardless of location, shape and background colour of license plate. So we eliminate the license plate location extraction as complex and time consuming individual stage [16]. All the steps simulated in Matlab 2014A software and results show the accuracy and reliability of this proposed method.
Interactive comment on “ The comparison of MODIS-Aqua ( C 5 ) and CALIOP ( V 2 V 3 ) aerosol optical depth

We assess the consistency between instantaneously collocated level-2 aerosol optical depth (AOD) retrievals from MODIS-Aqua (C5) and CALIOP (Version 2 & 3), comparing the standard MODIS AOD (MYD04 L2) data to the AOD calculated from CALIOP aerosol extinction profiles for both the previous release (V2) and the latest release (V3) of CALIOP data. Based on data collected in January 2007, we investigate the most useful criteria for screening the MODIS and CALIOP retrievals to achieve the best agreement between the two data sets. Applying these criteria to eight months of data (Jan, Apr, Jul, Oct 2007 and 2009), we find an order of magnitude increase for the CALIOP V3 data density (by comparison to V2), that is generally accompanied by equal or better agreement with MODIS AOD. Differences in global, monthly mean, over-ocean AOD (532 nm) between CALIOP and MODIS range between 0.03 and 0.04 for CALIOP V3, with CALIOP generally biased low, when all available data from both sensors are considered. Rootmean-squares (RMS) differences in instantaneously collocated AOD retrievals by the two instruments are reduced from values ranging between 0.14 and 0.19 using the unscreened V3 data to values ranging from 0.09 to 0.1 for the screened data. A restriction to scenes with cloud fractions less than 1 % (as defined in the MODIS aerosol retrievals) generally results in improved correlation ( R2 > 0.5), except for the month of July when correlations remain relatively lower. Regional assessments show hot spots in disagreement between the two sensors in Asian outflow during April and off the coast of South Africa in July.
Thiopental alters long term nociceptive response of young rats

The objective of this study was to evaluate the long term nociceptive response determined by use of two general anesthetics, one intravenous and the other inhalatory, in young animals. In the first experiment, the animals of 21 days of age were divided into control (saline) and thiopental (35 mg/kg, i.p.) groups. In the second experiment, rats of the same age were divided in two groups – halothane (2%) and control. In experiment 1, there was difference between groups – reduction of tail-flick latency in the group thiopental (P 0.05; F(1,19)=0.032 for the interaction, P>0.05). The results obtained in this study showed that halothane did not alter the nociceptive response in young animals. However, the thiopental induced hyperalgesic response in rats. Key words: Rats. Sodium thiopental. Halothane. Nociception. Tail flick latency. RESUMO O objetivo desse estudo foi avaliar a resposta nociceptiva a longo prazo relacionada ao uso de dois anestesicos gerais – um intravenoso e outro inalatorio, em animais jovens. No primeiro experimento, os animais de 21 dias de idade foram divididos nos grupos controle (solucao salina) e tiopental sodico (35 mg/kg, i.p.). No segundo experimento, animais de mesma idade foram divididos em dois grupos – halotano (2%) e controle. No Experimento 1, houve reducao da latencia de retirada da cauda no grupo tiopental (P 0,05; F(1,19)=0,032 para a interacao, P>0,05). Os resultados obtidos nesse estudo demonstraram que o halotano nao altera a resposta nociceptiva em animais jovens. Entretanto, o tiopental induziu resposta hiperalgesica nestes ratos. Palavras-chave: Ratos. Tiopental sodico. Halotano. Nocicepcao. Latencia de retirada da cauda.
A Proper Derivation of the 7 Most Important Equations for Your Retirement

In a recent book, Milevsky (2012) proposes seven key equations that are central to all retirement income calculations. The book itself presents these equations without deriving or proving them, and instead focuses on their history, usage and applicability. In this (brief) article I ll in the missing details by either deriving the equations themselves, or providing a detailed and specic technical reference. [Note. This is work in progress. ]
ON THE HIGHER EIGENVALUES FOR THE ∞-EIGENVALUE PROBLEM

We study the higher eigenvalues and eigenfunctions for the so-called ∞-eigenvalue problem. The problem arises as an asymptotic limit of the nonlinear eigenvalue problems for the p-Laplace operators and is very closely related to the geometry of the underlying domain. We are able to prove several properties that are known in the linear case p = 2 of the Laplacian, but are unknown for other values of p. In particular, we establish the validity of the Payne-Polya-Weinberger conjecture regarding the ratio of the first two eigenvalues and the Payne nodal conjecture, which deals with the zero set of a second eigenfunction. The limit problem also exhibits phenomena that are not encountered for any 1 < p < ∞.
THE IMMUNOSUPPRESSANT EFFECT COMPARATION BETWEEN ETHYL ACETATE AND N-BUTANOL FRACTIONS OF KALANCHOE PINNATA (LMK) PERS IN 2,6,10,14 TETRAMETHYLPENTADECANE-TREATED MICE

Immunosuppressant drugs are the main treatment of lupus patient. The ACR and SLICC treatment guidelines are able to increase the quality of life, but the outcome is not satisfying since the off-label therapy of corticosteroids and cytotoxic drugs give a lot of side effects. Many breakthrough efforts still develop in order to find the safe and effective drugs for lupus, such as finding immunosuppressant drugs from natural resources. One of the potential resources is Kalanchoe pinnata (Lmk) Pers, which have immunosuppressant, anti-inflammatory, antinociceptive, and antioxidant effects. Thus, in the previous study, we found the effect of the aqueous extract of Kalanchoe pinnata (Lmk) Pers is active to repair the lupus manifestation in 2,6,10,14 tetramethylpentadecane (TMPD)-treated mice. Then, this research was focused on the in vivo immunosuppressant effect of a flavonoid-rich fraction of the extract which was consisted of the ethyl acetate (FE) and n-butanol (FB) fractions. The induction method and the extraction procedure were the same as the previous study and then the fractionation was performed by using liquid-liquid extraction. After 2-week treatment of both fractions, we obtained the differences in the total leukocytes, organ indexes, and also the spleen, kidney, and joint structure parameters. The total leukocyte of the FE group was 3,600Â±264 cells/mm3, which was lower than that in the FB group. The spleen and kidney indexes increased after the administration of FB fraction, while the FE fraction was not. At last, despite the histology observation of spleen resembled mild structural changes differences, the clear differences between both treatment groups occurred in the kidney and joint histology. The differences led to a conclusion that the FE fraction has the better immunosuppressant effect in TMPD-treated mice.
Impact of National and Organizational Cultures on Information System Implementation in the Shipping Industry - A case study at a Swedish shipping company

A Swedish shipping company, called the SSC in this thesis for the sake of anonymity, initiated the implementation process of a new information system in 2016. The new system would replace seven of the organizations’ old systems to increase efficiency and integration as well as simplify further digitalization of processes. The implementation was planned to be completed in 2017, but when this thesis was conducted the implementation had only reached two of the organizations’ twenty vessels. Significant resistance from employees and managers had halted the implementation and the project manager and top management had previously only focused on solving technical issues. This thesis thus aimed to analyze the SSC’s information system implementation with the intention of giving proposals for improvement through organizational viewpoints. The aim of the thesis was broken down into three research questions through an analysis that connected the current situation of the organization to literature on resistance towards information system implementations. The research questions handled national culture, organizational culture, and change management. They were answered through an iterative process, where the researcher went back and forth between literature and empirical data collection, to conclude suggestions for improvements that were suitable for the organization. Empirical data was collected through interviews with eighteen employees, as well as by triangulation through observations and by utilizing assessment instruments to validate the thesis. The analysis found several dimensions of national culture that could impact the implementation process negatively. These dimensions were connected to change management and information system implementation research to provide solutions to the negative impact. Furthermore, it was found that several subcultures were present within the company that could further hinder the implementation process. It was suggested that the organization should attempt to create a more uniform, flexible organizational culture and strategy to increase the organization’s readiness for change for future change projects. The result of the thesis provided the SCC with suggestions for improvement, however, some aspects that need further investigation were presented. The aspects included a further investigation of the external and internal environment of the organization, both present and future, to aid in the decision of a suitable company strategy and culture. Furthermore, it was suggested that an investigation of the vessels that has not yet initiated the implementation was necessary as the thesis only focused on the two vessels that had initiated the implementation process.