Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence that autosomal recessive spastic cerebral palsy-1 (CPSQ1) is caused by a missense variant in HPDL

Abstract A subset of individuals diagnosed with cerebral palsy will have an underlying genetic diagnosis. Previously, a missense variant in GAD1 was described as a candidate mutation in a single family diagnosed with autosomal recessive spastic cerebral palsy-1 (CPSQ1; OMIM 603513). Following the ascertainment of a further branch of the CPSQ1 kindred, we found that the previously reported GAD1 variant did not segregate with the neurological disease phenotype in the recently ascertained branch of the kindred. Following genetic linkage studies to map autozygous regions and whole-exome sequencing, a missense variant (c.527 T > C; p. Leu176Pro, rs773333490) in the HPDL gene was detected and found to segregate with disease status in both branches of the kindred. HPDL encodes a 371-amino acid protein (4-Hydroxyphenylpyruvate Dioxygenase Like) that localizes to mitochondria but whose function is uncertain. Recently, biallelic loss of function variants and missense substitution-causing variants in HPDL were reported to cause a childhood onset progressive spastic movement disorder with a variable presentation. These findings suggest that HPDL-related neurological disease may mimic spastic cerebral palsy and that GAD1 should not be included in diagnostic gene panels for inherited cerebral palsy.
Interaction of substance use with physical activity and its effect on depressive symptoms among adolescents

ABSTRACT Objective: The present paper examined the association of physical activity and substance use with depressive symptoms among adolescents in lower socio-economic settings in India. We hypothesized that physical activity would be positively associated with lower depression levels and that the relationship would be inverse in case of substance use. Methods: We utilized data from the Understanding the lives of adolescents and young adults (UDAYA) survey. The depression level was assessed by combining nine questions on symptoms, having a higher internal validity (Cronbach alpha value: 0.86), and adopting a negative binomial regression model. Results: The study demonstrated a higher mean depression score among educated, girls, and adolescents who consumed substance and were not involved in physical activity. Adolescents who are physically inactive (IRR: 1.33; CI: 1.25–1.41) and use substance (IRR- 1.26; CI: 1.11–1.43) were more likely to have depressive symptoms compared to their counterparts. However, after controlling the effect of background variables, the incidence rate ratio (IRR) decreased for physical activities (IRR: 0.88; CI: 0.81–0.94) and increased for substance use (IRR: 1.39; CI: 1.22–1.58). Conclusion: Substance use predisposes adolescents toward depression; therefore, educating teens on the effects of substance use is important as it would control possible substance use among adolescents.
The study of dry biological valve crosslinked with a combination of carbodiimide and polyphenol

Abstract The glutaraldehyde crosslinked pericardium has been used in bioprosthetic valves for about 50 years. However, problems such as glutaraldehyde residue and calcification still exist in current commercial products. Non-glutaraldehyde crosslinked dry valve is an important strategy to solve those problems. In this study, a non-glutaraldehyde crosslinked dry biological valve material was obtained by the combined crosslinking of carbodiimide (EDC) and polyphenol. The results showed that the comprehensive properties of EDC and curcumin crosslinked pericardium were superior to glutaraldehyde crosslinked pericardium, including unfolding property, anti-calcification, cytotoxicity, anticoagulant properties, mechanical properties, enzyme degradation resistance and thermal shrinkage temperature. EDC and curcumin crosslinked dry pericardium could flatten after being folded at 40°C for 3 days while glutaraldehyde crosslinked pericardium could not. The calcification of pericardium treated with EDC and curcumin was 1.21 ± 0.36 mg/g in rats after 60 days’ subdermal implantation, much lower than that of glutaraldehyde treated control group (22.06 ± 3.17 mg/g).
CONSUMER DECISION MODEL FOR THE USE OF RAILWAY IN NEW NORMAL

This study aims to test a consumer decision model to travel in the new normal era through factors that encourage consumers to travel. This study used Theory of Planned Behavior (TPB) as a foundation in making the research model. The testing and application of TPB in this study emphasized the measurement of the influence of four variables, namely attitude, subjective norm, perceived behavior, and intention moderated by travel constraints. The data was collected through a structured questionnaire distributed via Google forms, and 178 sets of respondent data were collected using convenience sampling. The data was analyzed by using regression analysis and moderated regression analysis to measure the moderation power of the travel constraint variable. The results indicated that factors namely attitude, subjective norm, perceived behavior had significant and positive relation with behavioural intention. As themoderating variable, travel constraints showed negative relation through interactions, with subjective norms on intentions. This research provides the benefits of knowledge for academics and business people which enable them to further explore the aspects discussed as well as the effects that arise on the components of the TPB, so that they can also be used to design promotions.
Changes in phosphate availability of ultisols with long‐term cropping

Abstract Many soils in the southeastern United States have high levels of available P. Long‐term field studies were conducted to determine the amount of phosphorus (P) that could be supplied before corn (Zea mays L.) and soybean [Glycine max (L.) Merr. ] responded to P fertilization and changes that occurred in soil test P. The soils were a Norfolk loamy sand (fine‐loamy, siliceous, thermic Typic Kandiudult), Lynchburg loamy fine sand (fine‐loamy, siliceous, semiactive, thermic Aeric Paleaquult), and a Davidson clay loam (clayey, kaolintic, thermic Rhodic Kandiudult). Phosphorus as concentrated superphosphate was broadcast annually at rates of 0, 10, 20, and 40 kg P ha‐1. Response to P was obtained the 13th year of the study on the Davidson and the 14th year on the Norfolk. No response was obtained on the Lynchburg which had the highest level of available P. The Davidson soil supplied 130 kg P ha‐1 and the Norfolk 204 kg P ha‐1 before a response was obtained. The Lynchburg supplied 178 kg P ha‐1 during the.
A Comparison of Physical Activity and Exercise Capacity in Adults with Congenital Heart Disease and Healthy Controls

Purpose: Advancements in surgical and nonsurgical care for congenital heart disease (CHD) have enabled an increase in survival into adulthood of these children with CHD, thereby contributing to the growth of the aging population, it is important to evaluate these functional outcome measures in adults with CHD. Therefore, this study aimed to compare the subjective and objective assessments of physical activity (PA) and exercise capacity (EC) in adults with CHD and age-matched, healthy controls. Methods: Forty-six adults with CHD (male, 26; age, 20.6±1.3 years) and forty-six healthy controls (male, 24; age, 21.2±1.6 years) underwent an assessment of subjective and objective PA levels using the Global Physical Activity Questionnaire and the accelerometer device (GENEActiv) worn on the wrist for seven consecutive days, respectively. EC was directly measured by peak oxygen uptake (peak VO 2 ) during a graded exercise test. Results: Subjectively and objectively measured of moderate to vigorous PA in adults with CHD were lower than those with healthy controls (p=0.008, p=0.004), while the majority of adults with CHD have achieved the recommended levels of PA (150 min/wk). In addition, peak VO 2 was lower in adults with CHD than in healthy controls (30.8±8 mL/kg/min vs. 46.7±10 mL/kg/min, p ＜ 0.001). Conclusion: Although the majority of adults with CHD meet the recommended levels of PA, their overall PA levels and EC are still lower than those of age-matched, healthy adults without CHD.
Solid-State Ion-Exchange of Copper into Zeolites Facilitated by Ammonia at Low Temperature

The effect of the gas phase during solid-state ion-exchange of copper into zeolites was studied by exposing physical mixtures of copper oxides (CuI2O and CuIIO) and zeolites (MFI, *BEA, and CHA) to various combinations of NO, NH3, O2, and H2O. It is shown that heating these mixtures to 250 °C results in active catalysts for the selective catalytic reduction of NO with NH3 (NH3-SCR), indicating that the Cu has become mobile at that temperature. Such treatment allows for a fast (<5–10 h) preparation of copper-exchanged zeolites. Scanning transmission electron microscopy analysis of Cu-CHA prepared using this method shows homogeneous distribution of the Cu in the primary particles of the zeolite. In situ XRD reveals that the Cu ion-exchange is related to the formation of CuI2O. When the zeolite is mixed with CuIIO, addition of NO to the NH3-containing gas phase enhances the formation of CuI2O and the Cu ion-exchange. The mobility of Cu at low temperatures is proposed to be related to the formation of [CuI(NH.
Study of power flow and stability for a hybrid diesel-PV power system in Indonesia

Diesel power plants are still the main choice for supplying isolated grids in Indonesia. Although this kind of power plant is easy to install, it has a high cost of energy (COE) mainly due to the cost of diesel fuel. Besides, Indonesia as a tropical country has a high intensity of solar radiation. Moreover, the investment cost of PV power plant is getting lower and it does not require high operation cost. Thus, the implementation of PV power plant is considered promising in Indonesia, and the idea of combining diesel power plants with PV in isolated grids arises to increase the efficiency of the COE. Apart from the economical aspect, the technical aspect of a hybrid diesel-PV power system implementation needs to be studied as well. In this study, the impact of the PV power plant interconnection to the existing grid is analysed in terms of the power flow and the transient stability using the DIgSILENT PowerFactory software. Furthermore, a load-sharing scheme is applied to some diesel generator units. According to the simulation result, the hybrid power system operated within the allowable voltage limits. After some transient events occurred, the hybrid power system was able to maintain its stability.
The Medium of Exchange in Mergers and Acquisitions: The Cases of Travel Agencies and Tour Operators

The choice of the means of exchange is one of the critical decisions in mergers and acquisitions. Travel agencies and tour operating-industries compete in a volatile environment, and in addition to generating economies of scale, investments in the industry involve important sunk costs. This paper’s focus is on the determinants of the medium of exchange in mergers and acquisitions in the travel and tour-operating industries. Previous research on the ‘law and finance’ perspectives argues that some country of origin legal systems offer better investment protection to investors. Accordingly, civil law-based systems offer weaker protection to investors when compared to common-law-based systems. For this purpose, we use a logistics regression to model the determinants of cash in a sample of 750 mergers and acquisitions by combining the research streams above. Our results provide evidence of the relationship between investor protection and the use of cash.
Anomalous counterion condensation in salt-free hydrophobic polyelectrolyte solutions: Osmotic pressure measurements

The effective charge fraction feff of a highly charged hydrophobic polyelectrolyte (poly(styrene)-co-styrene sulphonate, sodium salt) has been measured as a function of the bare chemical charge fraction f between 0.38 and 1 by osmotic-pressure measurements complemented by cryoscopy. It was found that feff is highly reduced, compared to the prediction of counterion condensation theory and the measurements we made on a model hydrophilic polyelectrolyte. Furtheremore, feff varies linearly with the chemical charge fraction and extrapolates to zero effective charge at a chemical charge fraction of 0.18, a value close to the limit of solubility of the polyelectrolyte in water. We relate this anomalous behaviour to the variations of the local dielectric constant, measured previously with the same polyelectrolyte, a parameter which is not considered in the structural models for hydrophobic polyelectrolytes.
Phytochemicals and cancer chemoprevention

The unending morbidity and mortality that results from cancer, as well as adverse reactions due to chemotherapy and the enormous economic burden of treatment and hospitalization, advocates for the necessity of chemopreventive measures. Cancer chemoprevention refers to the use of agents capable of reversing, reducing, or slowing down the pathology of cancer at various stages. Fortunately, a few therapeutic drugs with relatively low toxicity (e.g., tamoxifen, finasteride), and a sparse number of vaccines (hepatitis B, HPV), are used to prevent specific cancers. In the general population, however, therapeutic options for cancer prevention are not common. Nonetheless, it is generally agreed that diet affects the genesis of cancer, and phytochemicals have the capacity of functioning as cancer chemoprevention agents. This is supported by epidemiological studies and clearly documented with animal models designed to mimic human carcinogenesis. Additionally, some public health strategies, such as recommendations for greater consumption of fruits and vegetables, reflect the merits of cancer chemoprevention. Here, we focus on some well-established natural product cancer chemopreventive agents, including resveratrol (grapes), epigallocatechin-3-gallate (green tea), sulforaphane (cruciferous vegetables), anthocyanins (grapes and berries), curcumin (turmeric), silibinin (milk thistle), and lycopene (tomatoes). As aptly demonstrated by genomic analysis and other methods, the mechanistic underpinning is variable and complex. In addition, responses may be mediated through indirect mechanisms, such as interaction with the microbiome. Furthermore, ancillary applications of chemopreventive agents are worthy of consideration, such as management of sequelae induced by chemotherapy. Recognizing the loss of millions of cancer patients every year, it is obvious that negating malignant metastatic conditions remains of paramount importance. In meeting this objective, cancer chemoprevention offers great promise. Page 2 of 36 Dave et al. J Cancer Metastasis Treat 2020;6:46 I http://dx.doi. org/10.20517/2394-4722.2020. 106
PROTECTEUR AUDITIF À ATTÉNUATION ACOUSTIQUE ACTIVE UTILISANT UN FILTRE NUMÉRIQUE

Passive hearing protection devices (earplugs and earmuffs) are effective only at high frequencies. A combination of those passive protection devices with an active attenuation system is of high interest because of the complimentarity of the two systems (the active systems are mainly effective at low frequencies). We have developped a miniaturized active systeme that could be used as an earplug. The correction filter has been implemented with a digital signal processor. Using this technology the development of adaptive systems might be possible in the near future.
Eggshell as a calcium source replacing limestone meal in mink (Neovison vison) diets

Dietary adequate intake of available Ca is essential for normal bone growth and development and many metabolic reactions. Recent literature on mineral requirements in mink is very limited, but the requirement for Ca and P in mink is estimated at 0.4% on a dry matter (DM) basis in the growing mink and 0.6% in lactating mink, assuming a Ca:P ratio of 1:1–2:1 (NRC, 1982). In mink fed large amounts animal by-products with contents of bone, diets are likely to contain Ca levels above the requirements and to exhibit a favourable Ca:P ratio. However, diets based on soft-tissue animal byproducts as fish, meat and organ tissues, and cereal grain sources, may contain abundant P but are likely to be deficient in Ca. In addition, high levels of P and phytate in plant ingredients may inhibit Ca absorption (Denstadli et al., 2010). These diets must be balanced by a Ca source with low contents of P to ensure fulfilled dietary Ca requirement and adequate Ca:P ratio. Eggshell is a large natural source of Ca with a potential to cover dietary Ca requirements. Eggshell contains about 34% Ca, mainly as calcium carbonate (94%), together with minor amounts of ABSTRACT. An experiment was carried out to study the suitability of ground eggshell as a calcium (Ca) source in mink (Neovison vison) diets replacing limestone meal. In the study two treatment groups of six multiparous lactating females were used. Animals were fed diets containing either eggshell or limestone from May 9 to weaning on June 15 (lactation period) and continued with 10 male kits from each respective group from June 16 until termination on November 28 (growing period). Moist diets containing mainly slaughterhouse by-products, fish, maize starch and soybean protein concentrate were used. The added eggshell or limestone represented about 60% of total Ca contents in the diets for lactating females and 27 (limestone diet) or 26% (eggshell diet) in the kit growing period. Growth performance, Ca and P digestibility, and femur development were studied. The apparent total tract digestibility (ATTD) of Ca and P of each diet was measured in six male kits. There were no significant differences between diets with added eggshell or limestone meal in ATTD of Ca and P, but eggshell tended (P < 0.06) to promote higher Ca digestibility than limestone. Replacing limestone with eggshell in the diets for growing kits resulted in significantly (P < 0.05) higher feed intake and weight gain, increased body length, and lowered feed efficiency ratio. Dietary eggshell significantly (P < 0.05) increased length and weight of femur in mink kits, whereas femur thickness and contents of ash, Ca and P were unaffected. So, it can be concluded that eggshell can replace limestone as a suitable Ca source in mink diets. Received: 7 September 2020 Revised: 3 November 2020 Accepted: 27 November 2020
FACS-Based Graph Features for Real-Time Micro-Expression Recognition

Several studies on micro-expression recognition have contributed mainly to accuracy improvement. However, the computational complexity receives lesser attention comparatively and therefore increases the cost of micro-expression recognition for real-time application. In addition, majority of the existing approaches required at least two frames (i.e., onset and apex frames) to compute features of every sample. This paper puts forward new facial graph features based on 68-point landmarks using Facial Action Coding System (FACS). The proposed feature extraction technique (FACS-based graph features) utilizes facial landmark points to compute graph for different Action Units (AUs), where the measured distance and gradient of every segment within an AU graph is presented as feature. Moreover, the proposed technique processes ME recognition based on single input frame sample. Results indicate that the proposed FACS-baed graph features achieve up to 87.33% of recognition accuracy with F1-score of 0.87 using leave one subject out cross-validation on SAMM datasets. Besides, the proposed technique computes features at the speed of 2 ms per sample on Xeon Processor E5-2650 machine.
Neural network implementation of controllers for multi-channel objects synthesized by polynomial method

The implementation of neural network multichannel controllers synthesized by polynomial matrix decomposition is analysed. Objects and controllers are assumed to be linear; these allow them to be described by matrix transfer functions. The transfer function of the object is converted to the right polynomial matrix inter-simple decomposition. The transfer function of the controller is sought in the form of a left polynomial matrix of inter-simple decomposition that allows leading the characteristic matrix to the form of a linear matrix polynomial equation with two matrix indeterminates. This equation is solved by leading to a matrix equation with numeric matrix indeterminates. Then the controller equation is converted to a discrete equation. The discrete sampling step is chosen small enough to allow the systems with continuous and discrete controllers have sufficiently close transient processes. The discrete controller is converted to a structure including delay elements, adder units and amplification coefficients. Then this structure is presented in the form of a set of neurons. The operation of the algorithm is illustrated by the example of the synthesis of an unstable inverted pendulum control, which includes two PID controllers. Possible increases in neuro controller performance are demonstrated. Two PID controllers are combined into one neural network in order to further optimization.
Integration of Cognitive Behavioral Therapy for Suicide Prevention in Social Work Practice

Purpose: To evaluate the integration of cognitive behavioral therapy (CBT) for depression and suicide prevention (CBT-SP) into social work practice with youth after a 2-day training and 3 months of group consultation. Method: A purposive sample of 22 clinical social workers completed a one-group pre–post and 3-month follow-up assessment to evaluate knowledge of CBT and CBT-SP, utilization, and barriers to utilization of CBT treatment and skills. Results: Knowledge of CBT and CBT-SP skills improved following training. All trainees integrated at least one new skill into practice and increased use of prior skills. No trainees integrated the full-manualized CBT-SP intervention into practice. Participation in group consultation increased the likelihood of integrating CBT-SP skills into practice for males and trainees with more practice experience. Discussion: The findings support the importance of training clinicians in common element skills of CBT and CBT-SP rather than only focusing upon integrating full-manualized treatments into social work practice.
The influence of domestication, insularity and sociality on the tempo and mode of brain size evolution in mammals

The ability to develop complex social bonds and an increased capacity for behavioural flexibility in novel environments have both been forwarded as selective forces favouring the evolution of a large brain in mammals. However, large brains are energetically expensive, and in circumstances in which selective pressures are relaxed, e.g. on islands, smaller brains are selected for. Similar reasoning has been offered to explain the reduction of brain size in domestic species relative to their wild relatives. Herein, we assess the effect of domestication, insularity and sociality on brain size evolution at the macroevolutionary scale. Our results are based on analyses of a 426-taxon tree, including both wild species and domestic breeds. We further develop the phylogenetic ridge regression comparative method (RRphylo) to work with discrete variables and compare the rates (tempo) and direction (mode) of brain size evolution among categories within each of three factors (sociality, insularity and domestication). The common assertion that domestication increases the rate of brain size evolution holds true. The same does not apply to insularity. We also find support for the suggested but previously untested hypothesis that species living in medium-sized groups exhibit faster rates of brain size evolution than either solitary or herding taxa.