Miracle-dz/UniFAR-FTUs huggingface dataset:
Examining the willingness of youths to participate in agriculture to halt the rising rate of unemployment in South Western Nigeria

Purpose The purpose of this paper is to investigate the willingness of unemployed graduates to participate in agriculture with a view to showcase the potentials in Nigerian agriculture especially in the area of employment generation for the youths. Design/methodology/approach The study made use of primary data collected with the aid of structured questionnaires from 180 respondents from the three states of Ondo; Oyo and Osun states are the representative states from the entire South West. The binary logistic regression model was used to identify those factors that influence the willingness of the respondents who were graduates of various disciplines to participate in agriculture. Findings The findings of the study showed that the majority of the respondents interviewed representing 62.8 percent were unemployed with the majority of the respondents (68.3 percent) willing to participate in agriculture given the needed and required supports such as conducive environment by the stakeholders particularly the government. Educational status, marital status, gender, possession of agricultural training and employment status of respondents significantly influenced their willingness to participate in agriculture. Research limitations/implications The greatest limitation of this study is its sample size which is considerably small but considering the peculiarity in the challenges faced by the entire population; this limitation has been overcome, thus, making its findings valid for policy purposes. However, recommendations for further studies that would comprise the entire geopolitical zones of the country to pave way for comparative analysis were made. Originality/value The study is originally carried out by conducting a survey to collect the data and is coming to fill the existing gap in the literature in terms of potentials embedded in Nigerian agriculture to assist the government in providing employment opportunities for teeming youths.
Assessment of Hepatocellular Carcinoma Metastasis Glycobiomarkers Using Advanced Quantitative N-glycoproteome Analysis

Hepatocelluar carcinoma (HCC) is one of the most common malignant tumors with high incidence of metastasis. Glycosylation is involved in fundamental molecular and cell biology process occurring in cancer including metastasis formation. In this study, lectin microarray, lectin blotting, lectin affinity chromatography and tandem 18O stable isotope labeling coupled with liquid chromatography-mass spectrometer (LC-MS) analysis were applied to quantify the changes in N-glycosite occupancy for HCC metastasis serum. Firstly, lectin microarray was used to screen glycoforms and Phaseolus vulgaris Leucoagglutinin (PHA-L) reactive structure (β1,6-GlcNAc branched N-glycan) was found to be increased significantly in HCC patients with metastasis compared with those with non-metastasis. Then, PHA-L affinity glycoproteins were enriched followed by N-glycosite occupancy measurement with strategy of tandem 18O stable isotope labeling. 11 glycoproteins with significantly changed N-glycosite occupancy were identified, they were associated with cell migration, invasion and adhesion through p38 mitogen-activated protein kinase signaling pathway and nuclear factor kappa B signaling pathway. Quantification of N-glycosite occupancy for PHA-L reactive glycoproteins could help to discover important glycoproteins of potential clinically significance in terms of HCC etiology. Also, understanding of N-glycosite occupancy alterations will aid the characterization of molecular mechanism of HCC metastasis as well as establishment of novel glycobiomarkers.
Modulation of steady‐state kinetics of digoxin by haplotypes of the P‐glycoprotein MDR1 gene

We investigated the effect of polymorphisms in the P‐glycoprotein (P‐gp) MDR1 gene on steady‐state pharmacokinetics of digoxin in Caucasians. According to earlier data, homozygous TT of the exon 26 complementary deoxyribonucleic acid (cDNA) 3435C>T polymorphism was associated with low P‐gp expression in the human intestine.
Minding their Ps and Qs; the Royal Navy purser and accounting and governance, 1731–1808

This research explores the accounting regulations imposed on sea officers, particularly the purser, on board Royal Navy ships between 1731 and 1808. This was a period in which the Royal Navy grew to become one of the largest enterprises in Europe with operations throughout the world. The governance, control and accountability practices imposed upon pursers are analysed. The Regulations for accounting records to be kept by pursers indicate that accounting changed very little in the analysis period, until 1808, when it became substantially more detailed. Drawing on institutional theory, it is argued that this was due to external pressures for increased governance following the impeachment of Melville (First Lord of the Admiralty), public spending administrative and accounting reforms and political disapproval of ‘offices of profit’. The article provides important insights to the development of accounting, governance, audit and accountability within the Royal Navy, and enhances understanding of the historically unique role of pursers.
The Impact of Talent Management on Perceived Organizational Performance in a Leading Telecommunication and Technological Companies in Colombo District

Area of the Study This study seeks to explore the impact of talent management on perceived organizational performance in leading telecommunication and technological companies in Colombo district, Sri Lanka. Problem of the Study The concept of talent management is not well researched in the Sri Lankan context. Especially, no studies have been found on the impact of talent management on perceived organizational performance in Sri Lanka. Hence, this study aims to find out the impact of talent management on perceived organizational performance in leading telecommunication and technology companies in Sri Lanka. Method of the study The target population of this study was the total number of telecommunication and technology companies in Sri Lanka. Out of the total population, four leading telecommunication and technology companies in Colombo district were selected by using convenient sampling technique. From the total number of executive level employees within these four companies, proportionately 240 executives were selected for the data collection. A structured questionnaire, which consisted of 47 statements with five point Likert scale was used. The data analysis included the univariate analysis and bivariate analysis. Findings of the Study This study found that there is a significant positive impact of talent management on perceived organizational performance in leading telecommunication and technology companies in Sri Lanka. Moreover, perceived organizational performance is positively correlated with the each dimension of the talent management namely talent acquisition, talent development and talent retention. As per the regression analysis, talent management has an impact of 59.6% on perceived organizational performance Also, the research found that there is same level of practice of talent management in telecommunication and technology companies in Sri Lanka. Conclusion of the Study It is concluded that there is a significant positive impact of talent management on perceived organizational performance in leading telecommunication and technology companies in Sri Lanka. In addition, dimensions of talent management (talent acquisition, talent development and talent retention) have a positive impact on perceived organizational performance of the sample. To enhance the overall performance within the telecommunication and technology
Rotavirus vaccines: entering a new stage of deployment

Purpose of review Rotavirus is the single most important cause of severe diarrhoea in infants and young children. This review provides updated information concerning three rotavirus vaccines that are being evaluated and introduced globally. Recent findings Two large, phase III clinical trials, each involving more than 60 000 infants in both developing and developed countries, demonstrated that both RotaTeq (Merck & Co., Whitehouse Station, New Jersey, USA), the pentavalent human-bovine reassortant vaccine, and Rotarix (GlaxoSmithKine Biologicals, Rixensart, Belgium), the monovalent live-attenuated human rotavirus vaccine, are safe with respect to intussusception when the first dose is administered between 6 and 12 weeks of age, and that both vaccines are 90–95% efficacious in preventing severe rotavirus gastroenteritis including hospitalization. The bovine (UK)-human rotavirus reassortant tetravalent (BRV-TV) vaccine, developed at the National Institutes of Health (USA), was licensed for local production in several developing countries. Summary Rotavirus vaccines are entering a new stage of deployment toward the goal of reducing morbidity and mortality attributed to rotavirus infection in developing countries, and hospitalizations and emergency visits caused by rotavirus in developed countries. High vaccine prices appear to offset cost savings, and may make policymakers even in wealthy countries hesitate to introduce a rotavirus vaccine into their childhood immunization programmes.
The Prader‐Willi Syndrome: A Study of 40 Patients and a Review of the Literature

Forty patients with the Prader-Willi syndrome have been examined. The typical features begin in gestational life with poor fetal vigor and difficulties with birth and post-partum feeding. The classical features of hypotonia, small hands and feet, cryptorchidism can be identified at this time. The delayed milestones, mental retardation and obesity become more prominent later. The average height of the patients in this series who were admitted to the Clinical Study Center was 149 cm and their weight was 114 kg. The weight and height curves show that Prader-Willi individuals are consistently shorter and heavier than normal children. Tests of endocrine function showed normal glucose tolerance. Insulin secretion was increased in relation to obesity. The rise in growth hormone (hGH) after injecting insulin to induce hypoglycemia and after the infusion of arginine was comparable to other obese individuals but was low in comparison to normal weight subjects. There was no rise in growth hormone with L-dopa administration, but there was a rise in hGH with the administration of 2-deoxy-D-glucose. The hypoglycemia produced by insulin was greater in the Prader-Willi patient than in obese controls. The rise in TRH (thyrotropin-releasing hormone) following the injection of TSH (thyrotropin stimulating hormone) was greater in the Prader-Willi patients than in the obese controls. Hypogonadism was routine in this series, and the response to LRH (luteinizing releasing hormone) was absent in all tested subjects. Treatment with clomiphene for 30 to 90 days significantly increased the response to LRH in three adult individuals who had not been treated with gonadal steroids previously and who were hypogonadal. Rectal temperature declined in three of the five Prader-Willi patients during exposure to an ambient temperature of 4 degrees C, but none of the three obese controls showed a decline. Food intake averaged 5167 kcal/d when six patients were given trays containing more food than they could eat. Food intake was not reduced when tryptophan was added to the diet. Salivary secretion was reduced in the Prader-Willi patients. A number of pulmonary function tests were significantly reduced in the study patients compared to obese or normal weight controls. The anatomic findings in four autopsied patients with the Prader-Willi syndrome showed no significant differences from those of obese subjects without this syndrome. The chromosomal pattern showed a deletion or translocation at chromosome 15 in 3 of 12 patients in whom this test was performed. These findings in 40 patients with the Prader-Willi syndrome have been compared with the information contained in 159 reports published in the medical literature.
Turcot's syndrome

Objective: To investigate the possibility that neuroepithelial tumors in Turcot's syndrome are caused by pleiotropic mutations in the gene for adenomatous polyposis coli (APC), a tumor-suppressor gene implicated in colonic cancer. Methods: We studied the inheritance patterns of genetic markers for the chromosome 5q21 region in 12 members of a Turcot's syndrome kindred with five affected members. We performed linkage analysis to detect linkage between the disease phenotype and DNA markers. Results: Marker D5S346, located 30 to 70 kilobases from the APC locus, showed evidence highly suggestive of linkage to the disease phenotype (lod score = 1.92). Conclusions: The data provide evidence that the tumor-suppressor gene implicated in APC and sporadic colon cancers may also cause malignant neuroepithelial tumors in Turcot's syndrome.
MSI phenotype and MMR alterations in familial and sporadic gastric cancer

Microsatellite instability (MSI) is a major pathway involved in gastric carcinogenesis occurring in 20% of gastric cancer (GC). However, it is not clear whether MSI phenotype preferentially occurs in the sporadic or familial GC, when stringent inclusion criteria are used. The aim of this study was to compare the frequency of MSI and hypermethylation of MLH1 promoter in a large series of familial GC patients (non‐HNPCC and non‐CDH1‐related) and sporadic cases. Additionally, we analysed the immunoexpression of MMR proteins in a fraction of cases. Overall, the frequency of familial GC was 7.1%, and the frequency of hereditary tumours was 4.6%. MSI phenotype and MLH1 hypermethylation frequencies were not statistical different between familial and sporadic GC settings. Further, the MSI phenotype was not associated with any clinico‐pathological features studied in the familial GC setting, whereas in the sporadic setting, it was associated with older age, female gender and intestinal histotype. Using our stringent Amsterdam‐based clinical criteria to select familial GC (number of cases, age of onset), we verified that sporadic and familial cases differed in gender but shared histopathological features. We verified that the frequency of MSI was similar in familial and sporadic GC settings, demonstrating that this molecular phenotype is not a hallmark of familial GC in contrast to what is verified in HNPCC. Moreover, we observed that the frequency of MLH1 hypermethylation is similar in sporadic and familial cases suggesting that in both settings MSI is not associated to MMR genetic alterations but in contrast to epigenetic deregulation.
No Antiinflammatory Effect of Short-Term Topical and Subcutaneous Administration of Local Anesthetics on Postburn Inflammation

Background and Objectives. To investigate the effect of topical and subcutaneous administration of local anesthetics on the inflammatory response to thermal injury in human volunteers. Methods. Sixteen healthy volunteers received identical burn injuries (49°C for 6 minutes) on the right and left calves with a 15 × 25 mm rectangular thermode. Eight subjects had topical 5% EMLA applied before and after burn injury, and another eight subjects were administered subcutaneous 0.5% bupivacaine infiltration before burn injury on the right or left leg. No treatment was applied to the contralateral leg in either group because this served as the control. The dermal response after burn injury in test areas with EMLA or bupivacaine and without treatment was compared 24 hours, 72 hours, 168 hours, and 14 days after burn injury. Results. No significant difference was found in the area of flare, development of blister and ulcerations, or the intensity of inflammation after burn injury between the control legs and EMLA- or bupivacaine-treated legs, respectively. Conclusion. No antiinflammatory effect of short-term preinjury and postinjury topical 5% EMLA or subcutaneous 0.5% bupivacaine could be demonstrated after thermal injury in human volunteers.
Consensus-based distributed droop control of synchronverters for isolated micro-grids

Since distributed interface converters (DICs) embedded in the isolated micro-grid (MG) usually have low inertia, high penetration of DIC-based MGs may result in poor voltage and frequency response when the grid experiences large disturbances. The synchronverter is proposed recently in which the DIC mimics conventional synchronous generators (SGs) by designing parameters of the SG into the droop control mechanism of the DIC. In this paper, the concept of consensus-based droop control for DICs is extended to the consensus-based droop control for synchronverters. It will be shown that proper power sharing can still be achieved by the second-order consensus-based droop control. The stability of the closed-loop system is explored by the transient energy function (TEF) approach. Numerical experiments on real-time simulators will be performed to validate the effectiveness of the proposed control mechanism. Comparison studies about various existing droop control will also be studied.
Financial Frictions and Interest Rate Shocks

We show that taking into account the optimal response of agents subject to financial frictions reproduces two empirical facts on the response to interest rate shocks: the decrease in the stock of money on impact and the gradual decrease in the real stock of money. Financial frictions are introduced as a cost of portfolio rebalancing. The model generates infrequent portfolio rebalancing and endogenous sticky prices. We obtain optimal rebalancing periods, prices, and money over time. Predetermined rebalancing periods imply counterfactual predictions. Considering the optimal response of agents is relevant to determine the response of monetary policy shocks.
Differential diagnosis between Alzheimer's and frontotemporal disease by the posterior cingulate sign.

UNLABELLED This was a study to evaluate the posterior cingulate sign in differential diagnosis between Alzheimer's and frontotemporal disease. The impending availability of effective treatment for Alzheimer's disease makes this differential diagnosis important. METHODS Images of 20 patients with clinically confirmed or autopsy-proven (10 patients) Alzheimer's disease and 20 patients with clinically confirmed or autopsy-proven (7 patients) frontotemporal disease were compared with the consolidated images of 20 elderly healthy control subjects. The (99m)Tc-hexamethylpropyleneamine oxime SPECT data on brain blood flow from each patient were compared with the consolidated control image using statistical parametric mapping. RESULTS Sixteen of 20 patients with Alzheimer's disease showed the posterior cingulate sign in the form of significant blood flow reductions; 1 of 20 patients with frontotemporal disease showed the posterior cingulate sign. That patient's illness has evolved into Alzheimer's disease. The remaining 19 patients were negative for the posterior cingulate sign. CONCLUSION When present, the posterior cingulate sign indicates the presence of Alzheimer's disease; it is apparently absent in frontotemporal disease, thus serving as a differential diagnostic sign. It was absent in 3 patients with proven tangle-predominant Alzheimer's disease.
An analysis of nonlinear vibrations of coupled thickness-shear and flexural modes of quartz crystal plates with the homotopy analysis method

We investigated the nonlinear vibrations of the coupled thickness-shear and flexural modes of quartz crystal plates with the nonlinear Mindlin plate equations, taking into consideration the kinematic and material nonlinearities. The nonlinear Mindlin plate equations for strongly coupled thickness- shear and flexural modes have been established by following Mindlin with the nonlinear constitutive relations and approximation procedures. Based on the long thickness-shear wave approximation and aided by corresponding linear solutions, the nonlinear equation of thickness-shear vibrations of quartz crystal plate has been solved by the combination of the Galerkin and homotopy analysis methods. The amplitudefrequency relation we obtained showed that the nonlinear frequency of thickness-shear vibrations depends on the vibration amplitude, thickness, and length of plate, which is significantly different from the linear case. Numerical results from this study also indicated that neither kinematic nor material nonlinearities are the main factors in frequency shifts and performance fluctuation of the quartz crystal resonators we have observed. These efforts will result in applicable solution techniques for further studies of nonlinear effects of quartz plates under bias fields for the precise analysis and design of quartz crystal resonators.
Membranes in motion: mitochondrial dynamics and their role in apoptosis

Abstract Mitochondrial dynamics is crucial for cell survival, development and homeostasis and impairment of these functions leads to neurologic disorders and metabolic diseases. The key components of mitochondrial dynamics have been identified. Mitofusins and OPA1 mediate mitochondrial fusion, whereas Drp1 is responsible for mitochondrial fission. In addition, an interplay between the proteins of the mitochondrial fission/fusion machinery and the Bcl-2 proteins, essential mediators in apoptosis, has been also described. Here, we review the molecular mechanisms regarding mitochondrial dynamics together with their role in apoptosis.
Characterization of the stimulus for reactive oxygen species generation in calcium-overloaded mitochondria

Abstract We have used two different probes with distinct detection properties, dichlorodihydrofluorescein diacetate and Amplex Red/horseradish peroxidase, as well as different respiratory substrates and electron transport chain inhibitors, to characterize the reactive oxygen species (ROS) generation by the respiratory chain in calcium-overloaded mitochondria. Regardless of the respiratory substrate, calcium stimulated the mitochondrial generation of ROS, which were released at both the mitochondrial-matrix side and the extra-mitochondrial space, in a way insensitive to the mitochondrial permeability transition pores inhibitor cyclosporine A. In glutamate/malate-energized mitochondria, inhibition at complex I or complex III (ubiquinone cycle) similarly modulated ROS generation at either mitochondrial-matrix side or extra-mitochondrial space; this also occurred when the backflow of electrons to complex I in succinate-energized mitochondria was inhibited. On the other hand, in succinate-energized mitochondria the modulation of ROS generation at mitochondrial-matrix side or extra-mitochondrial space depends on the site of complex III which was inhibited. These results allow a straight comparison between the effects of different respiratory substrates and electron transport chain inhibitors on ROS generation at either mitochondrial-matrix side or extra-mitochondrial space in calcium-overloaded mitochondria.
Modelling Customer Delight in Hotel Industry

It is not an exaggeration that the present-day competitive environment calls for continuous and consistent delivery of customer delight in any sector of the business. The studies conducted by separate researchers across different settings suggest the existence of a common model sequencing the events that lead to customer delight. This study attempts to empirically establish the model after conceptualizing it. Discriminant analysis is used as a basic tool to establish the relationship between different events using the data generated from a sample of repeat hotels guests. The results show that surpassing of expectations of the hotel guests affect their perception on pleasant surprises, which in turn affect their consequent happiness. Such happiness along with their perceived excitement and perceived positive feelings create a delighting experience for them. It is hoped that the findings shall encourage other researchers to test this model in different business environments.