Miracle-dz/UniFAR-FTUs huggingface dataset:
Intravenous Administration of Glutamate Ionotropic Antagonists in Healthy Rats, Induces Lymphopenia and Affects Their Hematological Profile

Background: Glutamate is one of the primary endogenous amino acids of the Central Nervous System (CNS). Research over the last years has proven the existence of glutamate subunit receptors in additional non-neuronal tissues outside CNS such as the hematopoietic system.The purpose of this paper is to define the possible in vivo effect of glutamate ionotropic antagonists MK-801and NBQX in the hematopoietic system as well as their possible use in the cure of hematopoietic diseases and on their use on patients with co-existing neurological and hematopoietic disorders. Methods : Glutamate ionotropic antagonists MK-801 and NBQX were administrated intravenously in male wistar rats of 250 - 350 g weight. Animals treated with glutamate antagonists (n = 24) were compared to a control group (n = 10). The following parameters were evaluated 12 h and 24 h after drug administraton: Full blood count with differential, aggregation intensity, plus CD3, CD54 and CD49a expression on T-lymphocytes with flow cytometry. Bone marrow was assessed with bone marrow smears. The results were analyzed by unpaired t-test. Results : Both ionotropic antagonists reduced white blood cells with early lymphopenia (P less than 0.05), whereas NBQX also increased Ht and Hb values (P < 0.05), but reduced platelet aggregation (P less than 0.05). T-cell surface activation markers, CD3, CD49a were reduced (P less than 0.05), whereas CD54 was increased (P less than 0.05) 12 h after both antagonists’ administration but 24 h after NBQX all markers were increased (P less than 0.05). Bone marrow cells were influenced in a way that peripheral blood changes and segmented cells showed a possible expression of glutamate receptors. Conclusions : It is concluded that glutamate ionotropic antagonists affect the hematological profile and bone marrow of healthy intact rats as well as blood elements functions. Further research is needed in order to define the in vivo effect of glutamate and glutamate receptor antagonists on hematopoietic system either as a toxic agent or as a therapeutical one. doi:10.4021/jh101e
Automated detection of diabetes using higher order spectral features extracted from heart rate signals

Diabetes Mellitus, often referred to as diabetes, is a chronic disease that affects a vast majority of world population. The percentage of people affected is increasing every year. Diabetes is very difficult to cure. It can only be kept under control. In this scenario, diagnosis of diabetes is of great importance. In this work, we used Heart Rate Variability HRV signals obtained from ECG signals for the purpose of diagnosis of diabetes. We employed signal processing methods to extract features from the HRV signal. Since HRV signals are of nonlinear nature, we made use of Higher Order Spectrum HOS based features for analysis. In this paper, we have extracted the HOS features from HRV signals corresponding to normal and diabetic subjects. These selected features were fed independently to seven classifiers namely Gaussian Mixture Model GMM, Support Vector Machine SVM, NaiveBayes classifier NB, K-Nearest Neighbour KNN, Probabilistic Neural Network PNN, Fuzzy classifier and Decision Tree DT classifier. The performance of these classifiers was evaluated using accuracy, sensitivity, specificity, positive predictive value, and the area under the receiver operating characteristics curve measures. We observed that the GMM classifier presented the highest accuracy of 90.5%, while the other classifiers presented accuracies in the range of 86.5% to 71.4%. Thus, the proposed Computer Aided Diagnostic CAD technique has the ability to detect diabetes efficiently by analyzing the subtle changes in ECG signals that are indicative of the presence of diabetes in a patient. Also, we have proposed unique bispectrum and bicoherence plots for normal and diabetes heart rate signals.
The First-aid strip of copolymer, produced by electrospinning

In the study of biomimetic material design, mimicking nanostructured thin film components can take the place of the extracellular matrix. The new types of thin film were fabricated by polylactic acid (PLA) and Chlorhexidine composite nano-fibers with three different polylactic acid (PLA) to Chlorhexidine ratios (PLA: Chlorhexidine = 50:50 wt % and 90:10 wt % ). The composite nano-fibers produced by electrospinning has high tensile strength. The materials analysis with nano-fibers was demonstrated via Fourier transform infrared (FT-IR) and scanning electron microscope (SEM). In the present study, we assessed the response of bacteria to different ratios of composite nano-fibers with regard to antibacterial activity and scanning electron microscope (SEM) observation. These results suggested that the composite nano-fibers have good antibacterial ability and release for a long period. The majority of the studies on electrospinning fibers of PLA to add Chlorhexidine from solutions [8], we have reported that molecular structures and antiseptic of electrospinning nanofibers Chlorhexidine is a chemical antiseptic. It kills (is bactericidal to) both gram-positive and gram-negative microbes, although it is less effective with some gram-negative microbes.It is also bacteriostatic. The mechanism of action is believed to be membrane disruption, and not ATPase inactivation as previously thought. Products containing chlorhexidine in high concentrations must be kept away from eyes (corneal ulcers) and the inner ear (deafness), although it is used in minute concentrations in some contact lens solutions. Materials and method Strains and chemical
You give more, I give more: “The impact of career growth on knowledge sharing behavior.”

Knowledge sharing plays a significant role in enhancing innovation and creativity. Understanding what factors influence knowledge sharing among individuals in an organization has been widely studied, especially factors which derived from social exchange and psychological contract theory. However, how career growth affects knowledge sharing behavior in terms of psychological contract theory has not been studied in the previous literature. Therefore, this study aims to investigate career growth’s effect on knowledge sharing in an organization. The career growth is reflected from four elements; career goal progress, professional ability development, promotion speed, and remuneration growth. From 85 questionnaires distributed to lecturers and staffs at Syiah Kuala University, the results support the hypothesis stating that there is a significant relationship between organizational career growth and knowledge sharing behavior. Keywords: Organizational career growth, knowledge sharing behavior.
Improving Ethical Decision Making Through the Application of Psychological Knowledge

The abstract is to be in fully-justified italicized text, at the top of the left-hand column as it is here, below the author information. Use the word “Abstract” as the title, in 12-point Times, boldface type, centered relative to the column, initially capitalized. The abstract is to be in 10-point, singlespaced type, and up to 150 words in length. Leave two blank lines after the abstract, then begin the main text. “One of the greatest reasons why so few people understand themselves is that most writers are always telling man what they should be, and hardly ever trouble their heads with telling them what they really are. ” Bernard Mandeville “Fable of the Bees” (1714)
Wide-field broad-band radio imaging with phased array feeds: a pilot multi-epoch continuum survey with ASKAP-BETA

The Boolardy Engineering Test Array is a 6 x 12 m dish interferometer and the prototype of the Australian Square Kilometre Array Pathfinder (ASKAP), equipped with the first generation of ASKAP's phased array feed (PAF) receivers. These facilitate rapid wide-area imaging via the deployment of simultaneous multiple beams within a 30 square degree field of view. By cycling the array through 12 interleaved pointing positions and using 9 digitally formed beams we effectively mimic a traditional 1 hour x 108 pointing survey, covering 150 square degrees over 711 - 1015 MHz in 12 hours of observing time. Three such observations were executed over the course of a week. We verify the full bandwidth continuum imaging performance and stability of the system via self-consistency checks and comparisons to existing radio data. The combined three epoch image has arcminute resolution and a 1-sigma thermal noise level of 375 micro-Jy per beam, although the effective noise is a factor 3 higher due to residual sidelobe confusion. From this we derive a catalogue of 3,722 discrete radio components, using the 35 percent fractional bandwidth to measure in-band spectral indices for 1,037 of them. A search for transient events reveals one significantly variable source within the survey area. The survey covers approximately two-thirds of the Spitzer South Pole Telescope Deep Field. This pilot project demonstrates the viability and potential of using PAFs to rapidly and accurately survey the sky at radio wavelengths.
Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.

UNLABELLED We have identified previously undiscovered BRAF in-frame deletions near the αC-helix region of the kinase domain in pancreatic, lung, ovarian, and thyroid cancers. These deletions are mutually exclusive with KRAS mutations and occur in 4.21% of KRAS wild-type pancreatic cancer. siRNA knockdown in cells harboring BRAF deletions showed that the MAPK activity and cell growth are BRAF dependent. Structurally, the BRAF deletions are predicted to shorten the β3/αC-helix loop and hinder its flexibility by locking the helix in the active αC-helix-in conformation that favors dimer formation. Expression of L485-P490-deleted BRAF is able to transform NIH/3T3 cells in a BRAF dimer-dependent manner. BRAF homodimer is confirmed to be the dominant RAF dimer by proximity ligation assays in BRAF deletion cells, which are resistant to the BRAF inhibitor vemurafenib and sensitive to LY3009120, a RAF dimer inhibitor. In tumor models with BRAF deletions, LY3009120 has shown tumor growth regression, whereas vemurafenib is inactive. SIGNIFICANCE This study discovered oncogenic BRAF deletions with a distinct activation mechanism dependent on the BRAF dimer formation in tumor cells. LY3009120 is active against these cells and represents a potential treatment option for patients with cancer with these BRAF deletions, or other atypical BRAF mutations where BRAF functions as a dimer.
QUALITATIVE ASSESMENT OF ECONOMIC EFFECTS OF INTEGRATION IN EU: THE CASE OF ALBANIA

TEverybody is conscious for the importance of Albanian integration in EU. But each of us must be aware of the fact, that this outstanding process is accompanied by some benefits and costs, which has to be paid by our society. The main objective of this study is to qualitatively asses the economic impact of Albanian integration in EU. The first section is dedicated to theoretically explanation of the types of effects of integration which may be: direct or directs ones, micro or macroeconomic effects, and short run or long run effects. In the second part I am mainly focused on a qualitative assessment of effects of Albanian economic integration in EU. The main benefits relate to the new opportunities that will be ushered in, principally arising from better access of Albanian exports to foreign markets, enhanced competitive structures and improvements in efficiency, which in the long run will strengthen the Albanian economy. The costs arise mostly from the change-over from a protected economy to an open competitive one, which could lead to a loss of income and employment. There are introduced in the third part, three main quantitative methods which are recommended to be used for a further step of quantifying the economic effects of Albanian integration in EU.
Structure, dielectric, and piezoelectric properties of CuO-doped K 0.5 Na 0.5 NbO 3 -BaTiO 3 lead-free ceramics

Lead-free piezoelectric ceramics 1� xK 0.5 Na 0.5 NbO 3 +xBaTiO 3 +y mol % CuO have been fabricated by an ordinary sintering technique. Our results show that the doping of CuO is effective in promoting the densification of the ceramics. With the doping of CuO, all the ceramics can be well sintered and exhibit a dense, pure perovskite structure. After the formation of a solid solution with BaTiO3, both the paraelectric cubic–ferroelectric tetragonal and ferroelectric tetragonal– ferroelectric orthorhombic phase transition temperatures decrease and a relax behavior is induced. Coexistence of the orthorhombic and tetragonal phases is formed in the ceramics with 0.04x 0.06 and y = 1.00 at room temperature. Because of the more possible polarization states arising from the coexistence of the two phases and the improved densification, the piezoelectric and dielectric properties of the ceramics are enhanced significantly. The ceramic with x = 0.06 and y = 1.00 exhibits the optimum properties: d33= 193 pC/ N, kp = 0.43, kt = 0.40, and TC = 314 ° C. On the other hand, the ceramics with 0x 0.01 and y = 1.0 exhibit excellent “hard” piezoelectric characteristics: kp 0.40, kt 0.47, Qm 1940, r 230, and tan 0.5%. © 2007 American Institute of Physics. DOI: 10.1063/1.2787164
An Empirical Analysis of Electricity Demand in Pakistan

Study utilizes cointegration and vector error correction analysis to determination the long and short run dynamics between electricity demand and its determinants. Study uses time series data for Pakistan from 1970 to 2010. Johansen cointegration test indicate that variables integrate in the long run. Error correction term reflects the convergence of variables towards equilibrium. Electricity acts as a necessity in short run and luxury in long run. Study concludes that effective price and income policies, group pricing policy and peak-load pricing policy should be exercised for electricity demand management. Keywords: Electricity Intensity; Peak-load Pricing; Derived demand; Pakistan JEL Classifications: Q400; Q410
In vitro Evaluation of antibacterial efficacy of aqueous extracts of Iranian Native Plants on the Standard Strains of Pseudomonas aeruginosa

IJMM 1393; 8(2): P 51-54 Background and Aim: Pseudomonas aeruginosa is the most common cause of nosocomial infections, that known as one of the most resistant bacteria against antibiotics and show resistance to a lot of common treatment. On the same basis, the aim of the present study is evaluation of the antibacterial activity of aqueous extracts of four kinds of Iranian native plants on the growth of P.aeroginosa and compare them with antibiotics.
Use of mulberry foliage for pigs in the integrated tropical systems

An intense work of research was carried out in different areas of the tropics between 1993 and 2003. The investigation was about the use of shrub-like and arboreous foliage of mulberry (Morus alba) as a source of protein for feeding pigs. The mulberry can be used in the tropic as a permanent crop integrated to systems of animal production, mainly of swines. According to the existing information about the use of mulberry foliage for feeding growing/fattening pigs, the conclusion was that between 20 and 25 % of the total ration could be constituted by mulberry foliage. The age of cut and the management of the planting fertilization are among the factors that can influence on the response of the herd. Further researches should be required but, over all things, the implementation of the available results for increasing the efficiency of the systems of swine production through the integration of the tree component as an essential subsystem because there are already enough data that benefit the use of mulberry foliage for feeding pigs.
Study of the Effectiveness of Cognitive Group Therapy in Relapse Prevention among Substance Abusers

This research project studies the cognitive group therapy effectiveness in relapse prevention among the outpatients in Uromiyan Welfare Self Introducing Center. The objective of this study is to increase the knowledge in relation with this method's effect on relapse prevention. The method used in this study was experimental method of pretest, posttest type with control group. To carry out this study project, 30 substance abusers were randomly selected and placed in two groups of experimental (15 people) and control group (15 people). The experimental group received cognitive group therapy in 12 sessions and the control group did not undergo any experiments. Measurement tools include relapse prediction scale, nonstructural clinical interview and educational program for cognitive group therapy. Research hypothesis: Cognitive group therapy has a positive effect on relapse prevention in substance abusers. For hypothesis test, t test was used. The conclusion obtained from the research showed that cognitive group therapy method has a positive effect on relapse prevention among narcotic dependents.
Characterization of the esterase isozymes of Ips typographus (coleoptera, scolytidae)

Four esterase isozymes hydrolyzing α-naphthyl acetate (α-NA) were detected screening whole body homogenates of larvae and adults of Ips typographus by electrophoresis. Two of the four isozymes (isozymes 3 and 4) were not detected by α-NA staining in the pupal stage, but topical application of juvenile hormone III (JH III) on the pupa induced these isozymes. The JH esterase (JHE) activity on the gel was associated with the proteins of isozyme 2. The compounds OTFP, PTFP, and DFP inhibited this catalytic activity of isozyme 2 on the gel at low concentrations, whereas the proteins of isozyme 3 and 4 were affected only at higher concentrations. A quantitative developmental study was performed to characterize which of the esterases hydrolyzed JH III, using a putative surrogate substrate for JH (HEXTAT) and α-NA. The I50 of several esterase inhibitors and the JH metabolites were also defined. All findings supported the results that a protein associated with isozyme 2 is catabolizing JH and that isozymes 3 and 4 are the main contributors to the general esterase activity on α-NA. The JHE from Tenebrio molitor was purified by affinity chromatography. Although the recovery was low, an analytical isoelectric focusing gel showed that the JHE activity of the purified enzyme. T. molitor cochromatographed at the same pl as the JHE activity of I. typographus. Arch. Insect Biochem. Physiol. 34:203–221, 1997. © 1997 Wiley-Liss, Inc.
A comparative assessment of the fi nancial costs and carbon bene fi ts of REDD + strategies in Southeast

REDD+ holds potential formitigating emissions from tropical forest loss by providing financial incentives for carbon stored in forests, but its economic viability is under scrutiny. The primary narrative raised in the literature is that REDD+will be of limited utility for reducing forest carbon loss in Southeast Asia, while the level offinance committed falls short of profits from alternative land-use activities in the region, including large-scale timber and oil palm operations.Here we assess the financial costs and carbon benefits of various REDD+ strategies deployed in the region.We find the cost of reducing emissions ranges from$9 to $75 per tonne of avoided carbon emissions. The strategies focused on reducing forest degradation and promoting forest regrowth are themost cost-effective ways of reducing emissions and used in over 60%of REDD+ projects. By comparing thefinancial costs and carbon benefits of a broader range of strategies than previously assessed, we highlight the variation between different strategies and draw attention to opportunities where REDD+ can achieve maximumcarbon benefits cost-effectively. Thesefindings have broad policy implications for Southeast Asia. Until carbonfinance escalates, emissions reductions can bemaximized from reforestation, reduced-impact logging and investing in improvedmanagement of protected areas. Targeting cost-efficient opportunities for REDD+ is important to improve the efficiency of national REDD+ policy, which in-turn fosters greaterfinancial and political support for the scheme.
Brazilian ADR’s traded on U.S exchange market: Behavior of stock prices after the disclosure of corruption scandals

Considering The Efficient-Market Hypothesis (EMH) and a recent Brazilian corruption scandal involving the company JBS and politicians, this study aimed to analyze whether the disclosure of the scandal abnormally affected the stock pricing of Brazilian companies that operate in the American market by issuing ADRs. The results show a loss of value on the day after the event and a cumulative post-event loss, which opposes the EMF; abnormal returns were found and there was not a rapid adjustment of prices.
An expost economic assessment of the intervention against highly pathogenic avian influenza in Nigeria

This study assesses the intervention against avian influenza in Nigeria. It applied a simple compartmental model to define endemic and burn-out scenarios for the risk of spread of HPAI in Nigeria. It followed with the derivation of low and high mortality risks associated to each scenario. The estimated risk parameters were subsequently used to stochastically simulate the trajectory of the disease, had no intervention been carried out. Overall, the intervention costs US$ 41 million, which was yearly disbursed in various amounts over the 2006-2010 period. The key output variables (incremental net benefit, disease cost, and benefit cost ratio) were estimated for each randomly drawn risk parameter. With a 12% annual discount rate, the results show that the intervention was economically justified under the endemic scenario with high mortality risk. On average, incremental benefit under this scenario amounted to US$ 63.7 million, incremental net benefit to US$27.2 million, and benefit cost ratio estimated to 1.75.
Blocking Effects of CSF Spleen Vaccine on Vertical Transmission of CSFV and PRRSV Co-infection in Sows

To investigate the blocking effects of classical swine fever (CSF) spleen vaccine on vertical transmission of classical swine fever virus (CSFV) and porcine reproductive and respiratory syndrome virus (PRRSV) co-infection in sows. Sows infected CSFV+PRRSV were selected from three large-scale pig farms and they were randomly divided into group I and group II. The sows in the group I were set as experimental group and vaccinated with CSF spleen vaccine at a 2 times normal dose per pig; and sows in group II were set as control group and vaccinated with CSF cell vaccine at a 6 times normal dose per pig. The antigens of piglets were detected by enzyme-linked immunosorbent assay (ELISA) method. Our results revealed that the blocking rate on the antigen of piglets in the experimental group (79.25%, 42/53) was significantly higher than that in the control group (50.94%, 27/53) (p<0.01). Collectively, these results demonstrate that CSF spleen vaccine has a good blocking effects on vertical transmission of CSFV+PPRSV co- infection in sows. Index Terms - classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV), sows, vertical transmission