Miracle-dz/UniFAR-FTUs huggingface dataset:
Vps33B is required for delivery of endocytosed cargo to lysosomes

Lysosomes are the main degradative compartments of eukaryotic cells. The CORVET and HOPS tethering complexes are well known for their role in membrane fusion in the yeast endocytic pathway. Yeast Vps33p is part of both complexes, and has two mammalian homologues: Vps33A and Vps33B. Vps33B is required for recycling of apical proteins in polarized cells and a causative gene for ARC syndrome. Here, we investigate whether Vps33B is also required in the degradative pathway. By fluorescence and electron microscopy we show that Vps33B depletion in HeLa cells leads to significantly increased numbers of late endosomes that together with lysosomes accumulate in the perinuclear region. Degradation of endocytosed cargo is impaired in these cells. By electron microscopy we show that endocytosed BSA‐gold reaches late endosomes, but is decreased in lysosomes. The increase in late endosome numbers and the lack of internalized cargo in lysosomes are indicative for a defect in late endosomal–lysosomal fusion events, which explains the observed decrease in cargo degradation. A corresponding phenotype was found after Vps33A knock down, which in addition also resulted in decreased lysosome numbers. We conclude that Vps33B, in addition to its role in endosomal recycling, is required for late endosomal–lysosomal fusion events.
Interpreting socio-technical co-evolution: Applying complex adaptive systems to IS engagement

Purpose – This paper seeks to understand how software systems and organisations co‐evolve in practice during an IS engagement. Seeks also to argue that complex adaptive system theory (CAS) provides an excellent lens to study the motor of co‐evolution due to its ability to frame the strategies and reinforcement models of actors and to illustrate this by recounting four narratives of the interaction, selection and adaptation of actors arising from a longitudinal case study of an IS engagement. Then sets out to consider how the complexity of the engagement emerges from the interrelationship of these narratives and how the adaptive behaviour of the various actors is both a response to and a driver of co‐evolution within the engagement.Design/methodology/approach – An interpretive case study was undertaken to examine the implementation of a novel academic scheduling and resource allocation system at a research‐intensive Australian university. The research was conducted over ten months, employing ethnographic m.
11C-Dihydrotetrabenazine β-Cell Imaging

11C-Dihydrotetrabenazine b-Cell Imaging The prevalence of diabetes is dramatically high, and the acquired type II form is particularly expected to further increase considerably (from 6.6% of the world population [285 million people] in 2010 to 7.8% [439 million people] in 2030) (1). Diabetes is caused by a disrupted secretion of insulin and a subsequent increase in plasma glucose levels. Insulin is produced by the b-cells of the 1–2 million islets of Langerhans in a pancreas. These islets represent only about 2%–3% of the pancreas cell mass, which consists mostly of exocrine tissue. Autopsy studies have shown that the relative b-cell volume is reduced by more than 50% in diabetic subjects,
Management of retrosternal goitres.

The role of thyroidectomy in patients with retrosternal goitre provides yet another area of surgical controversy. Traditional surgical dogma has considered the presence of retrosternal extension to be an independent absolute indication for thyroidectomy. Evidence-based medicine has replaced surgical dogma. Furthermore, increased use of radiological investigations, particularly cross-sectional imaging, has identified many patients with retrosternal goitre who are often asymptomatic. The optimum management of these patients is far less certain. These developments have prompted some thyroid surgeons to challenge the traditional surgical doctrine. It remains generally accepted that thyroidectomy is indicated for retrosternal goitre for patients with clinical symptoms (stridor or dysphagia) and/or radiological evidence of significant tracheal narrowing, oesophageal compression or SVC syndrome. The role of thyroidectomy for retrosternal goitre per se, in the absence of compressive symptoms and/or in the presence of tracheal deviation alone (without narrowing), remains the focus of controversy. The following two papers provide arguments for and against a didactic policy of thyroidectomy in asymptomatic patients with retrosternal goitre.
PISA Fen Başarı Testinin Madde Yanlılığının Kültür ve Dil Açısından İncelenmesi

Bu calismada, PISA 2006 testi maddelerinin farkli alt gruplarda DMF analizleri yurutulmustur. DMF analizleri Mantel Haenszel (MH), lojistik regresyon (LR), Alan indeksleri yontemleriyle gerceklestirilmistir. Turkiye, Avusturalya, Ingiltere ve Kanada basari testine iliskin veriler kullanilmistir. Uygulanan kitapciklardan farkli kultur farkli dil gruplamasi icin birinci ve besinci kitapcik; ayni kultur farkli dil ile farkli kultur ayni dil gruplamasi icin besinci kitapcik secilmistir. DMF’nin olasi nedenlerini belirlemek icin alan uzmanlarinin goruslerine basvurulmustur. Dilsel ve kulturel farkliliklar arttikca DMF’li madde sayisinin da arttigi gozlenmistir. Kullanilan teknige gore DMF’li madde sayisi degismektedir. DMF belirleme yontemlerine gore DMF’li ve DMF’siz maddeler icin bir tutarlilik bulunmamaktadir. Benzer yanlilik arastirmalarinda oldugu gibi bu calismada da Turkce ve Ingilizce formdaki aciklanan maddelerdeki DMF’nin olasi temel nedenleri; ceviri, program, kultur ve dile bagli farkliliklar olarak belirlenmistir.
Autoridade e formação: relações sociais na sala de aula e no recreio

Tomando como referencia principal a producao teorica de T.W. Adorno, M. Horkheimer e H. Marcuse, o estudo privilegiou a compreensao dos diferentes tipos de exercicios de autoridade professoral e suas possiveis associacoes com as relacoes sociais que se constituem entre alunos na sala de aula e durante o recreio. Foi realizada, em 2005, uma pesquisa empirica que privilegiou observacoes das relacoes sociais que se deram em um grupo de alunos da quarta serie de uma escola publica municipal de Ensino Fundamental da cidade de Sao Paulo. As observacoes na sala de aula incidiram sobre as frequencias de agressoes e repreensoes entre alunos; de suas participacoes nas atividades escolares e das repreensoes e dos elogios feitos pelos seus professores. Foram realizadas, tambem, observacoes que possibilitaram analisar as insercoes dos alunos nos grupos sociais organizados durante o recreio, assim como as atividades por eles desenvolvidas. Apos realizar o cotejamento entre os dois conjuntos de dados (principalmente por meio da construcao de tabelas, sociogramas e a realizacao de teste estatistico), as analises empreendidas permitiram verificar algumas associacoes entre o exercicio da autoridade do professor e a constituicao das relacoes sociais que se dao entre os alunos. Na amostra estudada, os alunos que foram mais repreendidos pelos professores, porque nao conseguiam desenvolver suas tarefas escolares, foram os mesmos que foram repreendidos pelo mesmo motivo pelos seus pares na sala de aula, assim como, tambem, tiveram dificuldades de insercao nos grupos sociais que ser formaram durante o recreio. No recreio, os alunos agredidos na sala de aula nao se integraram em grupos de sua propria turma; os elogiados pelos professores preferiam jogos ludicos e participavam de grupos estaveis; os repreensores e agressivos ocuparam o espaco central do recreio com jogos esportivos viris; os alunos participativos constituiram grupos estaveis. As pesquisas que se debrucam sobre as relacoes entre o que se passa na sala de aula e a constituicao das relacoes sociais que se desenvolvem entre os alunos durante o recreio, constituem uma perspectiva fertil, e pouco explorada, de estudos que visam ampliar a compreensao sobre a escola e os processos sociais que atuam sobre a formacao do individuo
Clinical Characteristics Associated With Treatment-Resistant Bipolar Disorder

Abstract There has been limited consideration and empirical studies on treatment-resistant bipolar disorder (TRBD). This exploratory study was designed to identify factors contributing to TRBD in patients with a bipolar (I or II) disorder. Patients were categorized with “low,” “medium,” or “high” levels of treatment resistance based on a) the total number of psychiatric medications received and, for a second analysis, b) the number of mood stabilizer medications received. The study identified a number of factors associated with TRBD, such as being female and older and having an older age at illness onset, a higher incidences of family depression, less likelihood of being in paid employment, a higher number of lifetime stressors, medical conditions and comorbid anxiety disorders, a different personality and temperament profile, and more regular use of benzodiazepines. There were few factors associated with TRBD when defined by number of mood stabilizers trialed. Potential explanations for these findings were explored.
Results in Knowledge-Based Program Synthesis

This paper reviews the entire PSI program synthesis system, summarizing progress made during the past two years. PSI synthesizes efficient programs from several types of abstract specifications. The paper presents a brief summary of PSI, an example dialogue demonstrating its performance, and a discussion of Its present capabilities. Explanation of the detailed operation of the system is omitted in this short paper. For an overview of prior work, see [Green-76]; for more details see [Ginsparg-78], [Steinberg-79], [Barstow-79], and [Kant-79] [Biermann-76] surveys related work in the automatic programming field.
AN OFDM platform for wireless systems testing: alamouti 2x1 MIMO example

In this paper, we present a real-time implementation of an OFDM hardware platform. The platform is based on HW blocks that can be put together to configure a wireless system based on OFDM modulation. The platform can be easily upgraded to test pre-coding cooperation algorithms. We evaluate the platform to implement a diversity Alamouti 2×1 MIMO scheme wireless system. The testbed is implemented using FieldProgrammable Gate Array (FPGAs) through Xilinx System Generator for DSP. Blocks for time-domain synchronization and channel estimation are key components necessary in transmission system that require good time synchronization and channel estimation for efficient demodulation. Key-Words: OFDM; FPGA; Software Defined Radio (SDR), CFO, LTE
The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes

With the increasing availability of continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII), the artificial pancreas (AP) (the commonly accepted term for closed-loop control [CLC] of blood glucose [BG] levels in diabetes) has become a hot area in translational research and industrial development. After a prolonged period of inpatient, clinical research center trials using cumbersome systems, the field has progressed rapidly over the past 2 years to long-term, free-living studies running AP algorithms on smartphones. Although it is still not a cure, the AP is the most promising advance in the treatment of diabetes at this time. This issue of Diabetes Care presents today’s AP state of the art, including reports on multinational home-use AP trials, studies in young children, the use of multihormonal approaches to mitigate meal-related hyperglycemia, and discussions of AP study designs and outcome measures. This collection of articles establishes the AP as a new diabetes treatment paradigm—not a single-function CGM or CSII device but an adaptable wearable network encompassing the patient in a digital treatment ecosystem. In its May 2014 issue, Diabetes Care featured the progress in the AP field in a series of articles labeled “Advances in Artificial Pancreas Development. ” In addition to an editorial discussing the state of the art of AP development in 2014 (1), the issue included original articles that covered a broad range of topics including analyses of the possible physiological inputs to CLC (2), real-time estimation of insulin sensitivity from CGM and insulin pump data (3), engineering of the AP algorithms (4), reports of predictive low-glucose suspend (LGS) systems (5), studies of overnight CLC at home (6), feasibility of the AP in type 2 diabetes (7), and the first around-the-clock outpatient CLC running a model predictive control (MPC) algorithm on a portable AP system (8). Since then, …
The nuclear GTPase Gsp1p can affect proper telomeric function through the Sir4 protein in Saccharomyces cerevisiae

The small Ras‐like GTPase Ran/Gsp1p is a highly conserved nuclear protein required for the nucleocytoplasmic trafficking of macromolecules. Recent findings suggest that the Ran/Gsp1p pathway may have additional roles in several aspects of nuclear structure and function, including spindle assembly, nuclear envelope formation, nuclear pore complex assembly and RNA processing. Here, we provide evidence that Gsp1p can regulate telomeric function in Saccharomyces cerevisiae. We show that overexpression of PRP20, encoding the Gsp1p GDP/GTP nuclear exchange factor, specifically weakens telomeric silencing without detectably affecting nucleocytoplasmic transport. In addition to this silencing defect, we show that Rap1p and Sir3p delocalize from their normal telomeric foci. Interestingly, Gsp1p was found to interact genetically and physically with the telomeric component Sir4p. Taken together, these results suggest that the GSP1 pathway could regulate proper telomeric function in yeast through Sir4p.
Facile synthesis of some novel 2 -substituted-4,6- diarylpyrimidines using4'-hydroxy-3',5'-dinitrochalcones andS- benzylthiouronium chloride

Various4'-hydroxy-3',5'-dinitrosubstituted chalcones 1and S-benzylthiouronium chloride (SBT) 2in thepresence ofDMF -organic bases (morpholine/ pyrrolidine/ piperidine) gave 4,6 -diaryl-2-(4-morpholinyl / 1 - pyrrolidinyl /1
Multipulse Adaptive Coherence for Detection in Wind Turbine Clutter

Radar tracking of aircraft targets at low elevation angles can be complicated by clutter from wind turbines, which we define to be clutter. In this paper, we study detection in a staring pulse-Doppler radar. By exploiting the second-order correlation structure of this wind-turbine clutter we derive a target detector that uses a sequence of adaptive coherence scores. The detector uses a multipulse coherence statistic consisting of an incoherent geometric average of coherently computed adaptive coherence scores. The detector compares favorably to a multipulse coherence detector that uses no modeling or estimation of the clutter.
Colloidal Dispersions of Gelled Lipid Nanoparticles (GLN): Concept and Potential Applications

The interest in using colloidal dispersions of gelled lipid nanoparticles (GLN) for different fields of application has increased in recent years, notably in cosmetic, dermatology, and/or pharmaceutics due to their capacity to immobilize compounds with poor water solubility. The pharmaceutical field desires to achieve lipophilic drug formulations which are able to conserve their stability, although it is well-known that emulsions and solid lipid nanoparticles (SLN) present a lack of stability over time, leading to system destabilization. Furthermore, stable colloidal dispersions of gelled oil particles do not affect the properties of the molecule to be delivered, and they result as an alternative for the previously appointed systems. This review is an attempt to present the reader with an overview of colloidal dispersions of GLN, their concept, formulation methods, as well as the techniques used for their characterization. Moreover, various application fields of organogel dispersions have been illustrated to demonstrate the potential application range of these recent materials.
Neural Correlates of Protection Motivation for Secure IT Behaviors: An fMRI Examination

Information security management programs have long included “fear appeals”, managerial communiqués designed to promote secure behaviors among organizational insiders. However, recent research has found a conflict between the predictions of contemporary fear appeal theory for how we expect individuals to experience fear appeals and what actually occurs in IS security situations. Using the opportunity presented by neuroimaging tools to examine cognitive and affective reactions to fear appeals, we take a comparative look at the contentions of fear appeal theory and the realities of what insiders experience neurologically when exposed to ecologically relevant IS security fear appeals. Our fMRI results suggest that fear appeals elicit threat and threat response assessments, which partially supports fear appeal theory but does not support the presence of an actual fear response. Furthermore, appraisals of recommended threat responses had a stronger impact on intentions to enact security behaviors than appraisals of the threat itself, which suggests that a focus on threats might be misplaced. Instead, focusing on ways to make the responses to the threats more appealing to users might work better. These controversial findings suggest future research that should explore how fear appeals play out in IS security and in what ways.
THE RESEARCH IN FISH GENETICS IN CROATIA AND FORMER YUGOSLAVIA

This is a review on fish genetics research in Croatia and former Yugoslavia, based on the analyses of all the articles published in four main journals (Ribarstvo Jugoslavije, Morsko ribarstvo, Ichthyologia and Acta Adriatica) since 1945 till disintegration of Yugoslavia in 1991. Most of the papers cover the fields on cytogenetics and hybridization (24 and 13 respectively). Eight papers were on fish selection and five on population genetics. Apart from those, five papers were written by foreign authors. Two groups of researchers from the University of Sarajevo were specially active. One of them lead by B e r b e r o v i } and S o f r a d  i j a did extensive work in cytogenetics, analyzing the karyotypes of many fish species, some of them endemic. Another one lead by V u k o v i } , investigated some natural hybrids and created many of them artificially, particulary among cyprinids. These results are presented in a special table. Contrary to the mountainous Bosnia where this type of research was of systematic and ecologic importance, in Croatia whwrw aquaculture was highly developed, the approach was quite different. The scientists from the University of Zagreb, H a b e k o v i } and T u r k , studied the hybridization and selection of important cultured cyprinids. Apart from these scientific groups, many papers were published by A l  S a b t i , who later became world famous in fish cytogenetics. The works of many other authors who contributed with papers in different fields of fish genetics are also described.
Extending the limits of transcatheter closure of atrial septal defects with the double umbrella device (CardioSEAL)

Objective To report initial findings from a selected group of patients with morphological variations of the atrial septal defect who underwent transcatheter closure with a second generation redesigned double umbrella device. Patients Two patients with abnormal location of the oval fossa and partial deficiency of the septal rim, three patients with multiple defects, and two patients with a multiperforated aneurysm of the interatrial septum (age range, 3.6–25.5 years). Methods Defects were closed with the double umbrella device (CardioSEAL) consisting of two sets of flexible arms (with central and two mid-arm hinges) covered with sewn Dacron patches. The implantation procedure was monitored by transoesophageal echocardiography. Results The diameter of the defect measured during transoesophageal echocardiography ranged from 7–18 mm and the balloon stretched diameter ranged from 13–21 mm. The size of the devices varied from 28–33 mm and the ratio of device size to defect size varied from 1.6–2.1. Two devices (23 and 28 mm) were chosen in a patient with two separated defects. No complications or serious arrhythmias were observed during implantation or follow up (median, 1.8 months). Residual shunting was trivial in three patients and mild in one patient (inferiorly located additional defect). Conclusions To extend the selection critera of an isolated central interatrial defect for transcatheter closure, some modifications of the implantation technique are needed. Using the redesigned double umbrella device, effective closure in patients with multiple or irregularly shaped atrial septal defects was achieved, indicating a broadening of the spectrum of transcatheter closure.
An agent architecture for implementing a virtual inhabitant

The current popularities of many online games and virtual communities are largely based on the diverse reactions of other users and social relationships among the users which computer-controlled characters hardly provide. In this paper, we propose an architecture for implementing an agent called virtual inhabitant which can provide diverse and social actions just like those of human-controlled characters. To achieve these human-like actions, the virtual inhabitant should behave diversely, live long in the virtual environment, make social relationships with others, keep the relationships in his lifetime, and have self-updating abilities. To fulfill these requirements, we design the architecture to utilize the agent's full rationality, discrepancies, and other human-like features such as oblivions, and so on as the essential sources of an agent's diverse and social actions. We roughly divide the architecture into four submodules and sophisticatedly design each module in order to support these features effectively. The proposed model can be used for implementing virtual inhabitant for online games, member of virtual community, and pedagogical agents in intelligent tutoring systems with merely selecting and combining the submodules included in the proposed architecture.
Cushing Syndrome Induced by Serial Occipital Nerve Blocks Containing Corticosteroids

A patient with chronic daily headaches developed overt signs of Cushing syndrome during treatment with serial occipital nerve block injections. Investigation demonstrated an exogenous source of corticosteroids as the cause of the Cushing syndrome in this patient, thus, implicating the corticosteroid component of the occipital nerve blocks. To our knowledge, this is the first report of Cushing syndrome caused by occipital nerve blockade. Caution is warranted in employing even usual therapeutic doses of synthetic corticosteroids, particularly in long‐acting or depot preparations.