Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Caffeic Acid Phenethyl Ester, Ellagic Acid, Sulforaphane and Curcumin on Diazinon Induced Damage to the Lungs, Liver and Kidneys in An Acute Toxicity Rat Model

Summary The aim of this study was to investigate the possible protective effects of caffeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphane (SFN) and curcumin (CUR) against the toxic effects of diazinon (DI). Sixty Sprague Dawley rats were randomly divided into 10 groups. Five groups were allocated as control groups comprising unmedicated control, CAPE, EA, SFN and CUR control groups. The remaining five groups were the study groups comprising DI, DI + CAPE, DI + EA, DI + SFN, and DI + CUR groups. The animals were sacrified 24 h after drug administrations. DI caused a decrease in acetyl cholinesterase (AChE) activity (P<0.05) and increases in γ-glutamyltransferase (GGT) and amylase activities. It also damaged the kidney, liver, and lung tissues. The negative effects of DI on these enzymes were confirmed histopathologically. Also, CAPE, EA, SFN and CUR reduced amylase and GGT activities and caused an increase in the AChE activities that were increased due to the toxic effects of DI. Thus, it was determined biochemically and histopathologically that these medication reduced the degenerative toxic effects created by DI in the lung, liver and kidney tissues. These findings led us to believe that CAPE, EA, SFN and CUR may be used as protective medicines in acute DI intoxication.
Ju n 20 16 Ψ-Epistemic Quantum Cosmology ?

This paper provides a prospectus for a new way of thinking about the wavefunction of the universe: a Ψ-epistemic quantum cosmology. We present a proposal that, if successfully implemented, would resolve the cosmological measurement problem and simultaneously allow us to think sensibly about probability and evolution in quantum cosmology. Our analysis draws upon recent work on the problem of time in quantum gravity, upon causallysymmetric local hidden variable theories, and upon a dynamical origin for the cosmological arrow of time. Our conclusion weighs the strengths and weaknesses of the approach and points towards paths for future development. email: p.evans@uq.edu. au email: s.gryb@hef.ru. nl email: karim.thebault@bristol.ac. uk
Modeling sustainable reuse of nitrogen-laden wastewater by poplar

ABSTRACT Numerical modeling was used to simulate the leaching of nitrogen (N) to groundwater as a consequence of irrigating food processing wastewater onto grass and poplar under various management scenarios. Under current management practices for a large food processor, a simulated annual N loading of 540 kg ha−1 yielded 93 kg ha−1 of N leaching for grass and no N leaching for poplar during the growing season. Increasing the annual growing season N loading to approximately 1,550 kg ha−1 for poplar only, using “weekly”, “daily” and “calculated” irrigation scenarios, yielded N leaching of 17 kg ha−1, 6 kg ha−1, and 4 kg ha−1, respectively. Constraining the simulated irrigation schedule by the current onsite wastewater storage capacity of approximately 757 megaliters (Ml) yielded N leaching of 146 kg ha−1 yr−1 while storage capacity scenarios of 3,024 and 4,536 Ml yielded N leaching of 65 and 13 kg ha−1 yr−1, respectively, for a loading of 1,550 kg ha−1 yr−1. Further constraining the model by the current wastewater storage volume and the available land area (approximately 1,000 hectares) required a “diverse” irrigation schedule that was predicted to leach a weighted average of 13 kg-N ha−1 yr−1 when dosed with 1,063 kg-N ha−1 yr−1.
An Adaptive Sensor Fusion Method with Applications in Integrated Navigation

The Kalman filter (KF) is a form of optimal estimator characterized by recursive evaluation, which has been widely applied to the navigation sensor fusion. Utilizing the KF requires that all the plant dynamics and noise processes are completely known, and the noise process is zero mean white noise. If the theoretical behaviour of the filter and its actual behaviour do not agree, divergence problems tend to occur. The adaptive algorithm has been one of the approaches to prevent divergence problems in the Kalman filter when precise knowledge on the system models is not available. Two popular types of adaptive Kalman filter are the innovation-based adaptive estimation (IAE) approach and the adaptive fading Kalman filter (AFKF) approach. In this paper, an approach involving the concept of the two methods is presented. The proposed method is a synergy of the IAE and AFKF approaches. The ratio of the actual innovation covariance based on the sampled sequence to the theoretical innovation covariance will be employed for dynamically tuning two filter parameters – fading factors and measurement noise scaling factors. The method has the merits of good computational efficiency and numerical stability. The matrices in the KF loop are able to remain positive definitive. Navigation sensor fusion using the proposed scheme will be demonstrated. Performance of the proposed scheme on the loosely coupled GPS/INS navigation applications will be discussed.
Attention-getting and attention-holding processes of infant visual preferences.

COHEN, LESLIE B. Attention-getting and Attention-holding Processes of Infant Visual Preferences. CHILD DEVELOPMENT, 1972, 43, 869-879. In a new procedure that permitted the independent assessment of attention-getting and attention-holding processes of various stimulus parameters, 18 male and 18 female 4-month-old infants were exposed to checkerboards varying in size and number of squares. The major finding was that the latency of turning toward the pattern was determined more by the size of the checkerboard than by the number of checks, while the duration of fixation was more a function of the number of checks than the size. Infants also tended to turn faster toward and look longer at the right side than the left. The results supported the contention that infant attention should be divided into separate attention-getting and attenion-holding processes.
Matched and mismatched appraisals of the effectiveness of communication strategies by family caregivers of persons with Alzheimer's disease.

BACKGROUND Communication problems stemming from Alzheimer's disease (AD) often result in misunderstandings that can be linked with problem behaviours and increased caregiver stress. Moreover, these communication breakdowns also can result either from caregivers' use of ineffective communication strategies, which paradoxically are perceived as helpful, or can occur as a result of not using effective communication strategies that are perceived as unhelpful. AIMS The two primary aims were to determine the effectiveness of strategies used to resolve communication breakdowns and to examine whether caregivers' ratings of strategy effectiveness were consistent with evidence from video-recorded conversations and with effective communication strategies documented in the literature. METHODS & PROCEDURES Twenty-eight mealtime conversations were recorded using a sample of 15 dyads consisting of individuals with early, middle and late clinical-stage AD and their family caregivers. Conversations were analysed using the trouble-source repair paradigm to identify the communication strategies used by caregivers to resolve breakdowns. Family caregivers also rated the helpfulness of communication strategies used to resolve breakdowns. Analyses were conducted to assess the overlap or match between the use and appraisals of the helpfulness of communication strategies. OUTCOMES & RESULTS Matched and mismatched appraisals of communication strategies varied across stages of AD. Matched appraisals by caregivers of persons with early-stage AD were observed for 68% of 22 communication strategies, whereas caregivers of persons with middle- and late-stage AD had matched appraisals for 45% and 55% of the strategies, respectively. Moreover, caregivers of persons with early-stage AD had matched appraisals over and above making matched appraisals by chance alone, compared with caregivers of persons in middle- and late-stage AD. CONCLUSIONS & IMPLICATIONS Mismatches illustrate the need for communication education and training, particularly to establish empirically derived evidence-based communication strategies over the clinical course of AD.
Development of an in vitro Micro-organ Model for Pharmacokinetic Microanalysis

An in vitro model that can realistically and inexpensively predict human response to various drug administration and toxic chemical exposure is needed. By fabricating a microscale 3D tissue analog consisting of an array of channels and tissue-embedded chambers, we can selectively biomimic different mammalian tissues for a multitude of applications, foremost among them experimental pharmaceutical screening for efficacy and toxicity. Our model may be envisioned as an important adjunct for assessing the beneficial and detrimental effects of novel drugs upon navigating a given metabolic pathway. Most exemplary, assessing the therapeutic or toxic effects of a drug on any cell type in vitro may be investigated in the presence of microencapsulated liver cells to take into account the liver-dependent metabolic modification of the candidate drug. Future functional studies will also be conducted for drug therapeutic benefit or toxicity evaluation at a downstream tissue chamber housing a target soft parenchymal tissue to form a multi-compartment tissue chamber.
Long noncoding RNA H19 derived miR-675 regulates cell proliferation by down-regulating E2F-1 in human pancreatic ductal adenocarcinoma

The long noncoding RNA (lncRNA) H19 has been proven to be overexpressed in human pancreatic ductal adenocarcinoma (PDAC). H19-induced PDAC cell proliferation is cell cycle-dependent by modulating E2F-1. However, the mechanism of how H19 regulates E2F-1 remains unclear. In this study, we investigated the expression of miR-675 in PDAC tumours and cells, the biological function of miR-675 in PDAC cell proliferation and the possible relationship among H19, miR-675 and E2F-1. As a transcript of the first exon of H19, the level of miR-675 was negatively correlated with H19 expression in microdissected PDAC tissues (r=-0.0646, P=0.001). The serum miR-675 expression was significantly down-regulated in patients with PDAC compared to those in healthy individuals. Moreover, an evaluation of five PDAC cases showed that there was a remarkable increase of serum miR-675 levels after resection of the primary tumours. Ectopic overexpression of miR-675 in AsPC-1 and PANC-1 cells decreased cell viability, the colony-forming ability and the percentage of cells in S phase; contrarily, miR-675 knockdown resulted in enhanced cell proliferation. Furthermore, the suppressed cell proliferation caused by H19 knockdown could be rescued by inhibiting miR-675 expression. Additionally, intratumoural injection of either miR-675 agomir or antagomir could significantly affect tumour growth in vivo. Both the bioinformatic prediction and luciferase activity assay confirmed that E2F-1 was a direct target of miR-675. And the decrease of E2F-1 protein expression caused by siH19 could be partially reversed by miR-675 knockdown. We concluded that there might be a H19/miR-675/E2F-1 regulatory loop in cell cycle modulation. Serum miR-675 might serve as a potential biomarker for not only early diagnosis but also outcome prediction in PDAC.
Limnology: Lake and River Ecosystems

Preface 1 Prologue 2 Water as a Substance 3 Rivers and Lakes - Their Distribution, Origins, and Forms 4 Water Economy 5 Light in Inland Waters 6 Fate of Heat 7 Water Movements 8 Structure and Productivity of Aquatic Ecosystems 9 Oxygen 10 Salinity of Inland Waters 11 The Inorganic Carbon Complex 12 The Nitrogen Cycle 13 The Phosphorus Cycle 14 Iron, Sulfer, and Silica Cycles 15 Planktonic Communities: Algae and Cyanobacteria 16 Plantonic Communities: Zooplankton and their Interactions with Fish 17 Bacterioplankton 18 Land-Water Interfaces: Larger Plants 19 Land-Water Interfaces: Attached Microorganisms, Littoral Algae, and Zooplankton 20 Shallow Lakes and Ponds 21 Sediments and Microflora 22 Benthic Animals and Fish Communities 23 Detrirus: Organic Carbon Cycling and Ecosystem Metabolism 24 Past Productivity: Paleolimnology 25 The Ontogeny of Inland Aquatic Ecosystmes 26 Inland waters: Understanding is Essential for the Future References Appendix Index
Nintedanib for the treatment of patients with advanced non-small-cell lung cancer

An unmet need remains for effective, well-tolerated treatment options in advanced non-small-cell lung cancer that can alleviate the disease burden for a broad selection of patients. Nintedanib (Vargatef) is a potent, oral, triple angiokinase inhibitor of three distinct pro-angiogenic pathways. A recent Phase III trial of second-line nintedanib plus docetaxel met the primary end point of progression-free survival and demonstrated significant benefit in the key secondary end point of overall survival, with median overall survival greater than 1 year for patients with adenocarcinoma histology. This article summarizes preclinical and clinical experience with nintedanib in non-small-cell lung cancer to date and discusses how it may be used in the future, including prospects for individualizing treatment by tumor proliferation dynamics and molecular biomarkers of response.
Exploring nuclear pore complex structure and function in molecular detail

SUMMARY Bidirectional molecular trafficking between the nucleus and the cytoplasm of eukaryotic cells occurs through the nuclear pore complexes (NPCs), ∼120 megadalton supramolecular assemblies embedded in the double-membraned nuclear envelope. Significant progress has been made in elucidating the three-dimensional (3-D) architecture of the NPC, and in identifying, characterizing, and cloning and sequencing NPC proteins. Several of these have now been localized within the 3-D structure of the NPC. Nevertheless, there still remain major questions relating to the conformation, molecular composition and functional roles of distinct NPC components. Here we review recent structural studies from our group and others which have contributed toward dissecting the molecular architecture of the NPC. We also present our results on the molecular characterization of some NPC components, and on the elucidation of their functional roles in mediated nucleocytoplasmic transport.
Evaluation des prescriptions de risperidone à libération prolongée au centre psychothérapique de Nancy entre 2005 et 2008

Les neuroleptiques a action prolongee constitue le traitement de reference du patient schizophrene non observant. En mars 2005, la risperidone a liberation prolongee (RisperdalConsta [marque deposee] LP), premier antipsychotique de deuxieme generation a action prolongee, a ete commercialisee, combinant ainsi les avantages d'un neuroleptique a action prolongee a ceux d'un antipsychotique de deuxieme generation et modifiant les conditions de prise en charge du patient schizophrene non observant. L'objectif de ce memoire est de realiser une evaluation des prescriptions de Risperdalconsta [marque deposee] LP depuis sa mise a disposition des services de soins au Centre Psychotherapique de Nancy (CPN). Le recueil des informations s'est fait a partir des releves nominatifs de dispensation du Risperdalconsta [marque deposee] LP, des prescriptions informatisees et du dossier medical des patients. Le bilan d'utilisation de ce medicament au CPN a ete realise sur une periode de 39 mois. La part du RisperdalConsta [marque deposee] LP dans le budget medicament du CPN a ete evaluee : elle a augmente entre 2005 et 2008 et represente actuellement 16% de ce budget. L'evaluation des prescriptions de RisperdalConsta [marque deposee] LP a ete effectuee en tenant compte des recommandations d'utilisation de ce produit. D'avril 2005 a juin 2008, 238 patients ont recu au moins une injection de RisperdalConsta [marque deposee] LP au CPN. Parmi eux, 72% etaient traites pour un trouble mental de la categorie F20-F29 (schizophrenie, trouble schizotypique et troubles delirants) et 49% pour schizophrenie : ce qui est en conformite avec les indications du RCP du RisperdalConsta [marque deposee]LP. Le RisperdalConsta [marque deposee] LP a ete utilise au long cours au CPN chez 33 des 238 patients. Lors de l'instauration du traitement, l'equivalence posologique entre risperidone per os et le RisperdalConsta [marque deposee] LP ainsi que la duree de chevauchement entre les deux formes de risperidone ont ete conformes au RCP du RisperdalConsta[marque deposee] LP chez un peu plus de la moitie des patients. La prescription d'un correcteur de TEP au cours du traitement par RisperdalConsta [marque deposee] LP a eu lieu chez 37% des patients, mais seuls 13% ont beneficie d'une instauration de traitement par correcteur de TEP. L'arret du RisperdalConsta [marque deposee] LP a eu lieu chez 93 des 238 patients et pour 50% d'entre eux dans les six premiers mois de traitement par RisperdalConsta [marque deposee] LP. Le bon usage d'un traitement par neuroleptique a action prolongee est d'autant plus important qu'il diminue le risque de rechute chez des patients schizophrenes non observants. Cependant, il est important de garder a l'esprit que la seule utilisation d'un neuroleptique retard n'est pas suffisante pour reduire le risque de survenue d'une eventuelle nouvelle decompensation psychotique. En effet, la prise en charge therapeutique de la schizophrenie est non seulement pharmacologique, mais aussi psychologique et sociale.
Actin nucleation by a transcription co-factor that links cytoskeletal events with the p53 response

Despite its obvious importance in tumorigenesis, little information is available on the mechanisms that integrate cell motility and invasion with nuclear events. Tumor suppressor p53 is a DNA damage responsive transcription factor which initiates a checkpoint response culminating in cell cycle arrest or apoptosis. JMY is a transcription co-factor that functions in the nucleus during the p53 response. By forming a DNA damage-dependent complex with the p300 co-activator and the Mdm2 oncoprotein, JMY takes on a significant role in regulating the p53 response. Here, we discuss recent studies describing an unexpected cytoplasmic role of JMY in regulating cell motility and invasion. Control of cadherin expression and actin nucleation allows JMY to influence cell motility and invasion, contrasting with its nuclear role as a p53 co-factor which drives the response to DNA damage. JMY therefore connects cell motility and invasion with the p53 response, and its aberrant regulation is likely to significantly contribute to tumorigenesis. How these findings might relate to JMY's role as a transcription co-factor are discussed, as well as the mechanisms through which JMY integrates cytoskeletal events and cellular motility with the DNA damage response.
Building timelines of soccer matches from Twitter

This demo paper presents a system that builds a timeline with salient actions of a soccer game, based on the tweets posted by users. It combines information provided by external knowledge bases to enrich the content of tweets and applies graph theory to model relations between actions (e.g. goals, penalties) and participants of a game (e.g. players, teams). In the demo, a web application displays in nearly real-time the actions detected from tweets posted by users for a given match of Euro 2016. Our tools are freely available at https://bitbucket.org/eamosse/event_tracking.
Ranking the Leading Risk Factors for Sudden Unexpected Death in Epilepsy

Background Sudden unexpected death in epilepsy (SUDEP) is rare in well-controlled epilepsy. However, SUDEP is a common cause of death in drug-resistant epilepsy. Over the last 30 years, multiple cohort and population studies have identified clinical risk factors associated with an increased risk for SUDEP. Objective To identify and rank the leading SUDEP risk factors from major cohort and population-based studies. The incidence of SUDEP is also evaluated in special clinical situations, including antiepileptic drug treatment, epilepsy surgery, devices, and assignment to placebo in clinical trials. Methods A PubMed search for English language human cohort studies for the terms Sudden, Death, and Epilepsy was performed for the years 1987–2017. Risk factors for SUDEP were identified and ranked by the weighted log adjusted odds ratio (OR)/relative risk ratio (RR). Findings The top 10 leading risk factors ranked from highest to lowest log adjusted OR/RR are the following: ≥3 GTC seizures per year; ≥13 seizures in the last year; No Antiepileptic Drug (AED) treatment; ≥3 AEDs; ≥3 GTCs in the past year; 11–20 GTC seizures in the last 3 months; age of onset 0–15 years old; IQ < 70; 3–5 AED changes in the last year; ≥3 AEDs. Two risk factors from separate sources (≥3 GTC seizures and ≥3 AEDs) occur twice in the top 10 risk factors. Conclusion The top 10 risk factors for SUDEP are identified and ranked. A ranking of the top risk factors could help clinicians identify patients at highest risk for SUDEP.
Quantitative analysis ageing status of natural ester-paper insulation and mineral oil-paper insulation by polarization/depolarization current

Polarization and Depolarization Current (PDC) technique is an effective tool to assess the condition of oil-paper insulation system in power transformers. So far the PDC behaviors of mineral oil-paper insulation have been widely investigated. However, with the increasing number of transformer choosing natural ester as its insulation oil, it is important to investigate the PDC characteristics of natural ester-paper insulation to see whether the PDC technique can also be used to assess the condition of new insulation system using natural ester in transformers accurately. In this research, natural esterpaper insulation sample and mineral oil-paper insulation sample were subjected to thermally accelerated ageing experiment at 110°C for 120 days. The PDC characteristics of natural ester-paper insulation sample and mineral oil-paper insulation sample were compared over the ageing process. A new method for assessing the ageing condition of the oil-paper insulation in terms of the depolarization charge quantity was proposed. Results show that the polarization/depolarization current of natural ester-paper insulation sample is higher than that of mineral oil-paper insulation sample with the same ageing intervals. The depolarization charge quantity of both kinds of oil-paper insulation sample is very sensitive to their ageing conditions. There is an exponential relation between the stable depolarization charge quantity of both kinds of oil-paper insulation sample and the degree of polymerization (DP) of paper. The depolarization charge quantity can be used to predict the ageing condition of oil-paper insulation providing the measurement temperature is kept the same.
Molecular Diversity of Intestinal Microbiota in Dysbacteria Diarrheal Mice Associated with Ultra-micro Qiweibaizhusan

Qiweibaizhusan; Ultra-micro Chinese medicine; ARDRA; intestinal microflora; metagenome; molecular diversity. To study the micro-ecological mechanism of curative effect of ultra-micro Qiweibaizhusan on mice with dysbacteria diarrhea. The mice model with dysbacteria diarrhea was constructed by gavaging mixed antibiotics composing of gentamycin sulfate and cefradine for 5 days. And then, all the mice were fed with sterile water, 100% dose of traditional Qiweibaizhusan and 50% dose of ultra-micro Qiweibaizhusan for 3 days. At the same time, normal group mice were fed with sterile water. The faecal samples respectively were collected from intestinal tracts of mice. The metagenome DNA of intestinal microbiota was extracted and the 16S rDNA was amplified from these DNA samples