Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulation of Ca Release in Cardiac Myocytes by Changes in Repolarization Rate Role of Phase-1 Action Potential Repolarization in Excitation-Contraction Coupling

The early rate of action potential (AP) repolarization varies in the mammalian heart regionally, during development, and in disease. We used confocal microscopy to assess the effects of changes in repolarization rate on spatially resolved sarcoplasmic reticulum (SR) Ca release. The kinetics and peak amplitude of Ca transients were reduced, and the amplitude, frequency, and temporal synchronization of Ca spikes decreased as the rate of repolarization was slowed. The first latencies and temporal dispersion of Ca spikes tracked closely with the time to peak and the width of the L-type Ca current (ICa,L), suggesting that the effects of repolarization on excitationcontraction coupling occur primarily via changes in ICa,L. Next, we examined the effect of changes in the rapid early repolarization rate (phase 1) of a model human AP on SR Ca release by varying the amount of transient outward K current. Slowing of phase-1 repolarization also caused a loss of temporal synchrony and recruitment of Ca -release events, associated with a reduced amplitude and lengthened time to peak of ICa,L. Isoproterenol application enhanced and largely resynchronized SR Ca release, while it increased the magnitude and shortened the time to peak of ICa,L. Our data demonstrate that membrane repolarization modulates the recruitment and synchronization of SR Ca release via ICa,L and illustrate a physiological role for the phase-1 notch of the AP in optimizing temporal summation and recruitment of Ca -release events. The effects of slowing phase-1 repolarization can be overcome by -adrenergic stimulation. (Circ Res. 2002;90:165-173.)
Response to planned treatment interruptions in HIV infection varies across childhood

Objective: To evaluate clinical, immunological and virological consequences of CD4-guided antiretroviral therapy (ART) planned treatment interruptions (PTIs) compared with continuous therapy in children with chronic HIV infection in the Paediatric European Network for Treatment of AIDS 11 trial. Design: This was a multicentre, 72-week, open, randomized, phase II trial. Methods: One hundred and nine children with HIV-RNA below 50 copies/ml and CD4% of at least 30% (2–6 years) or at least 25% and CD4 cell count of at least 500 cells/μl (7–15 years) were randomized to continuous therapy (53) or PTI (56). In PTI, ART was restarted if confirmed CD4% was less than 20% or more than 48 weeks had been spent off ART. The primary outcome was Centers for Disease Control and Prevention (CDC) stage C event, death or CD4% less than 15% (and CD4 cell count less than 200 cells/μl for children aged 7–15 years). Results: At baseline, median (interquartile range) age was 9 (6–12) years, CD4% 37% (33–41), CD4 cell count 966 (793–1258) cells/μl, nadir CD4% before combination ART 18% (10–27), time on ART 6 (3–6) years and 26% were CDC stage C. After median (range) 130 (33–180) weeks of follow-up, 4 versus 48% of time was spent off ART in continuous therapy and PTI, respectively. No child died or had a new CDC stage C event; one (2%) continuous therapy versus four (7%) PTI children had a primary outcome based on CD4%/cell count (P = 0.2). Lower nadir CD4% predicted faster CD4% decline after stopping ART. Younger age and higher nadir CD4% predicted being off ART for at least 48 weeks and better CD4% recovery following PTI. Conclusion: In this first paediatric trial of PTI, there were no serious clinical outcomes. Younger children had better CD4% recovery after PTIs. Immunology substudies and long-term follow-up in Paediatric European Network for Treatment of AIDS 11 trial are ongoing. Further research into the role of treatment interruption in children is required, particularly, as guidelines now recommend early ART for all infected infants.
DETERMINANTS OF ADOPTION OF ENERGY EFFICIENCY PROGRAMMES AMONG MANUFACTURING SMALL AND MEDIUM ENTERPRISES IN NAIROBI COUNTY, KENYA

The study sought to establish the determinants of adoption of energy efficiency programmes among small and medium enterprises in the manufacturing industry in Kenya by taking the case of Nairobi County. It was guided by the accompanying explicit destinations: to set up the impact of data accessibility on selection of vitality effectiveness programs among little and medium ventures in the assembling business in Kenya; to decide the impact of limit expanding on reception of vitality proficiency programs among little and medium endeavors in the assembling business in Kenya; to discover the impact of budgetary asset accessibility on appropriation of vitality productivity programs among little and medium undertakings in the assembling business in Kenya and to build up the impact of government approach on reception of vitality effectiveness programs among little and medium undertakings in the assembling business in Kenya. The investigation focused on proprietor chiefs of assembling SMEs inside Nairobi County from the objective populace of 6514 SMEs. An example size of 376 proprietors of SMES in the assembling area in Nairobi County was discovered utilizing the Yamane equation. The specialist utilized polls to gather essential information. The outcomes and discoveries were displayed in tables, figures and graphs. The discoveries uncovered that the SMEs connected present day vitality the board frameworks to control for vitality use. The investigation found that that work force are prepared to build up costs, advantages and dangers for explicit activities. Monetary asset accessibility has a solid and positive criticalness in the reception of vitality effectiveness programs among SMEs in the assembling business in Kenya. The investigation found that there are required gauges particularly of consolidating boilers and local sun oriented vitality frameworks. The investigation reasoned that money related assets accessibility had the best impact on reception of vitality proficiency programs among SMEs in the assembling business in Kenya, trailed by data accessibility, trailed by government approach then limit building had minimal impact on appropriation of vitality productivity programs among SMEs in the assembling business in Kenya. The investigation prescribes that preparation approaches ought to be acquainted with the SMEs proprietors as district governments take a gander at SMEs International Journal of Arts and Entrepreneurship. Vol.8 Issue 8 (2019) www.ijsse. org ISSN 2307-6305 Page | 2 as a method for giving work to the numerous jobless adolescents, they ought to think about putting resources into these individuals by giving instruction and preparing. The study further recommends that that SMEs should clearly set-up financial priorities at commencement stage.
Effects of the addition of sand and string to pens on use of space, activity, tarsal angulations and bone composition in broiler chickens

Fast-growing broiler chickens use pen-space heterogeneously and have low activity levels, related in part to leg problems. The aim of this study was to test the effects of the addition of string and sand trays to rearing pens on the use of space, levels of activity and leg problems. Broiler chickens were reared in 12 pens (40 birds per pen). Drinkers and feeders only were present in the six control pens (C group), whereas the six other pens were enriched (E group) with two sand trays and string. Behaviour was recorded by scan and focal sampling on days 2-3, 13-14, 23-24 and 34-35. Bodyweight, the occurrence of tarsal deformities and the composition of tibiotarsi were measured on day 37. Chickens from the E group spent more time and stood more often in the area enriched with sand than did the g group birds. ghickens in the E group foraged in the sand throughout the rearing period, and their foraging activities were greater than those of the C group birds. They had little interest in the strings. Locomotor activity during standing bouts was enhanced in the E group on days 2-3 only. Bodyweight at day 37, the occurrence of tarsal deformities and the composition of tibiotarsi were not significantly different between groups. These results indicate that sand could attract chickens into areas that are usually rarely used, which may reduce problems resulting from their heterogeneous distribution. However, the results also indicate the difficulty of stimulating locomotion.
Identifying Discrete Fracture Networks by Clustering with Microseismic Data

Microseismic monitoring is common in the mining and petroleum industries. Pattern recognition to identify faults, fractures, and damage zones in the microseismic data can be a challenge due to the density and number of observations and their multiple attributes. This study applies unsupervised machine learning techniques to identify features in a dataset from a hydraulic fracturing program in the Duvernay Formation. It compares partitional, hierarchical, and density based clustering methods using various validation statistics and with multiple subsets of data attributes. The study shows that lower dimensional datasets tend to yield the best results, and that it is possible to cluster microseismic data using unsupervised techniques. RÉSUMÉ La surveillance microsismique est importante pour les industries minières et pétrolières. La reconnaissance des formes pour identifier les failles, les fractures et les zones endommagées dans les observations microsismiques est difficile en raison de la densité et le nombre d'observations et de leurs multiples attributs. Cette étude applique des techniques d'apprentissage machine sans supervision pour identifier les caractéristiques des observations d'un programme de fracturation hydraulique dans la Formation Duvernay. Il compare les méthodes de classification par partition, hiérarchique, et basée sur la densité en utilisant diverses statistiques de validation et avec plusieurs sous-ensembles d'attributs de données. L'étude montre que les ensembles de données avec moins d’attributs donner les meilleurs résultats, et qu'il est possible de regrouper les observations microsismiques en utilisant des techniques non supervisées.
An Untethered Electro-Pneumatic Exosuit for Gait Assistance of People With Foot Drop

Individuals with foot drop caused by stroke or cerebral palsy (CP) have a particular need for robotic ankle exoskeleton. This paper proposes an untethered soft robot using an origami actuator to lift the toes of the wearer. The weight, connections, and complex control of the system are reduced through mechanical design. A compact and portable pneumatic system is designed to perform suction and compression with a single pump. The load test of the actuator shows the capability of 300N in 30 kPa. An untethered, simple and affordable robotic ankle exoskeleton is developed with the pneumatic actuator. The wearer can finish its simple 3-step donning procedure within 1 min.
An exploration of the experiences of mental health and addictions nurses providing clinical supervision in a New Zealand District Health Board

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OPINION Editorial: update on scleroderma and other fibrosing syndromes

DOI:10.1097/BOR.0000000000000120 With the turn of the century, the knowledge of the pathogenesis of fibrosing disorders has revolutionized, largely because of better understanding of the molecular mechanisms of fibrosis. This section update gives us a glimpse of the recent advances in the field from internationally renowned experts in scleroderma (SSc) and other fibrosing syndromes. Considerable advancement has been made in the last 1 to 2 years in the field of fibrosis, and hence a section discussing these advances was necessary. In addition, the field of microvasculopathy associated with scleroderma also needed to be updated because important advances have been made in this field as well. Also included are updates on gastrointestinal manifestations, SSc-associated interstitial lung disease and pulmonary hypertension, as well as implications of different autoantibody subsets in SSc, and an update on accelerated atherosclerosis and macrovascular disease. Furthermore, a section on scleromyxedema, a close scleroderma mimic, but with distinct differences, was included, as readers should be acquainted with novel therapeutic updates for this rare but potentially life-threatening condition. Castelino et al. (pp. 607–614) do a remarkable job in bringing us up to date on the regulation of fibrosis at a molecular level and introduce us to some novel targets for disrupting the fibrotic process in SSc. The authors discuss how this may be achieved by interfering with cytokine pathways, affecting the destiny of mesenchymal cells, slowing down senescence, dispelling activated myofibroblasts, and modulating the milieu of the extracellular matrix. The fundamental role of microvascular endothelial cells (MVECs) in the pathogenesis of scleroderma is emphasized by Altorok et al. (pp. 615–620). The authors highlight the principal mechanisms of MVEC injury. In addition to initiation of scleroderma microvasculopathy, MVECs are thought to be involved in the activation of fibroblasts through certain cytokine and growth factor release, including CCN2, leading to production of a highly active population of fibroblasts. Epigenetic factors also seem to play an important role in the pathogenesis
Mixed-Frequency Bayesian VAR Models in R : the mfbvar package

Time series are often sampled at diﬀerent frequencies, which leads to mixed-frequency data. Mixed frequencies are often neglected in applications as high-frequency series are aggregated to lower frequencies. In the mfbvar package, we introduce the possibility to estimate Bayesian vector autoregressive (VAR) models when the set of included time series consists of monthly and quarterly variables. The package implements several common prior distributions as well as stochastic volatility methods. The mixed-frequency nature of the data is handled by assuming that quarterly variables are weighted averages of un-observed monthly observations. We provide a user-friendly interface for model estimation and forecasting. The capabilities of the package are illustrated in an application.
QUALITATIVE DETECTION OF RESIDUAL PESTICIDES ON COTTON FIBERS

This study is focused on a biosensor based measurement of bio-electrical signals caused by enzymatic inhibition of acetylcholinesterase (AChE) for the qualitative detection of organophosphorous and carbamate pesticides which are the strong inhibitors of AChE and prevents its normal function of the rapid removal of acetylcholine (Ach). Biosensor Toxicity Analyzer (BTA) was used for the testing and enzyme activity was determined by acetylthiocholine chloride (ATCCl) as enzyme substrate. The monitoring of changes in bio-electrical signals caused by the interaction of biological substances and residues were evaluated. Two samples of cotton were analyzed. Cryogenic homogenization was carried out for sample pretreatment and Soxhlet extraction method (SOX) was used for extraction. The resulted extracts were concentrated and then injected in the BTA. The method shows reasonable results and can successfully be utilized for the detection of residual pesticides on different types of cotton.
Practitioner Perspectives on Animal-Assisted Counseling

The field of animal-assisted counseling (AAC) is burgeoning. However, there is a paucity of research on the perspectives of mental health practitioners regarding its practice and the experience and training needed to effectively utilize AAC with clients. The purpose of this study was to explore how practitioners perceive AAC and its role in clinical settings. Perceptions of 300 mental health practitioners were assessed using a researcher-developed survey instrument. Findings indicated that a majority of practitioners (91.7%) view AAC as a legitimate counseling modality. Practitioners identified client age ranges and the top five clinical issues that would benefit from AAC. While only 12.0% of respondents had received training in AAC, 57.0% of respondents reported interest in receiving AAC training. Respondents identified types of AAC education, training, and supervision that would be sufficient for clinicians to utilize AAC. The findings from this study contribute to the emerging literature on AAC.
Intraoperatively Taken and Used Autologous Blood Transfusion; A Cost-Effective and Beneficial Way of Blood Transfusion in Cardiac Surgery: A Retrospective Clinical Trial

Aim: In recent years autologous blood transfusion (ABT) seems to be more beneficial than allograft blood transfusion in coronary artery bypass, major vascular surgery and other surgeries that have increased elective blood transfusion risk. This current retrospective controlled study aimed to show that the intraoperatively taken and transfused ABT (iABT) is practical, beneficial and cost-effective. Material and Method: Cardiac surgery patients were investigated from January 2017 to November 2018. Fifty-eight patients’ clinical data were investigated. During the process; the cross-clamp time and the extracorporeal perfusion time, volume of blood loss, blood transfusions needed were investigated. During the intensive care unit hospitalization extubation, ICU hospitalization time, the volume of blood loss, blood transfusions needed were examined. Also, total hospitalization time, the total volume of blood loss, total blood transfusions required, 30 days of mortality and one year of mortality were investigated. Results: Fifty-eight patients’ (23 female and 35 male) clinical data were investigated. ICU time was significantly shorter than the patients who were not transfused with iABT (p<0.05). Intraoperative, ICU stay, and total blood loss were significantly lower than who were not transfused with the iABT(p<0.05). Discussion: This current study showed that the iABT is more beneficial than allograft blood and blood products transfusions. The iABT is related to less blood loss in operation and during the ICU stay, causing decreased risk of complications. According to less blood loss, fewer blood products transfusion is also a cost-effective benefit.
Pelvic floor rehabilitation during and after pregnancy for the prevention of stress urinary incontinence

Bottom line Pelvic floor muscle therapy (PFMT) is effective for preventing and treating urinary incontinence (UI), especially if initiated during pregnancy (SOR: A, systematic reviews). PFMT started postpartum may not have an effect on urinary incontinence (UI) in primiparous women evaluated after 6 months (SOR: B, based on a single high-quality RCT). There is minimal risk involved in PFMT as a treatment for UI.
Study of factors affecting drug compliance in schizophrenia- cross sectional survey

Introduction: Schizophrenia is a condition characterized by delusions, hallucinations, disorganized behavior, disorganized thought, and negative symptoms. There is overwhelming evidence that antipsychotics can be effective in treating the symptoms of schizophrenia. Approximately 75% of individuals relapse without drugs compared to 25% with drug. Patients who receive long-acting depot have lower relapse rates than patients who receive oral medications. The factors affecting drug compliance include side effects, psychopathology, social support, and insight. Indian studies are comparatively few in this area; knowledge of these factors can help in formulating strategies for enhancing drug compliance and outcome. Methods: This study was conducted at the Department of Psychiatry T D Medical College, Alleppey, a tertiary care teaching hospital. Patients who attended the Outpatient department were assessed with following instruments, Positive and negative symptom scale, Udvalg Klinske Undersogelser Side Effect Rating Scale, Multidimensional scale of perceived social support, Scale to assess Unawareness of Mental Disorder (SUMD), Compliance was assessed by using the criteria of fully compliant defined as those miss less than 20% of medication, partially compliant those who misses 20% to 80% of medication and noncompliant those who miss more than 80% of medicines. Data was analysed using Chi square test and regression analysis. Result: Sex, Education status, marital status, Occupation, and drugs administered had significant relationships with Compliance. Conclusion:, it is advisable to use minimum number of drugs for ensuring compliance.
ABTRACT THE EFFECT OF MANAJERIAL OWNERSHIP, INSTITUTIONAL OWNERSHIP, THE NUMBER OF INDEPENDENT BOARD OF COMMISSIONERS, AND AUDIT COMMITTE ON EARNINGS MANAGEMENT PRACTICES

Manajerial ownership, institusional ownership, board of commisioner, and audit committee existence are elements of good corporate governance. Good Corporate Governance is needed in for the company to have advanced aspects of transparency, independence, accountability, responsibility, and fairness of the actions taken by management to raise or lower the gain in earnings management practices. The aim of this study is to examine the impact of independent variabel such as manajerial ownership, institusional ownership, the number of independent board of commissioners, and audit committee on dependent variabel earnings management practices by using multiple and simple linear regression method to gain the related coeficients. This study uses 63 sample manufacture financial statement from 2013 until 2015 enlist in BEI. The result from this study shows that there are negative significant independent variable such as manajerialownership and the number of board of independent commissioner with dependent variable on earnings management. However, both of the institusional ownership and the number of Audit Commitee are insignificant with earnings management. Subsequently, The data result shows that independent variable such as manajerialownership, institusional ownership, the number of board of independent commissioner and the number of Audit Commitee are insignificant with earnings management by using multiple linear regression.
Mechanisms of Vascular Smooth Muscle Cell Migration Endothelial Cell Migration During Angiogenesis Endothelial Precursor Cell Migration During Vasculogenesis Leukocyte Migration in the Vascular Wall Molecular Mechanisms of Endothelial Cell Migration

Migration of endothelial precursor cells (so-called “angioblasts” in embryos and “endothelial progenitor cells” in adults) during vasculogenesis is a requirement for the formation of a primary vascular plexus. The migration is initiated by the change of endothelial precursors to their migratory phenotype. The endothelial precursor cells are then guided to the position where the primary vascular plexus is formed. Migration is stopped by the reversion of the cells to their nonmigratory phenotype. A combination of regulatory mechanisms and factors controls this process. These include gradients of soluble factors, extracellular matrix–cell interaction and cell–cell interaction. In this review, we give an overview of the regulation of angioblast migration during embryonic vasculogenesis and its relationship to the migration of endothelial progenitors during postnatal vascular development. (Circ Res. 2007;101:125-136.)