Miracle-dz/UniFAR-FTUs huggingface dataset:
to assess lesions of ovary using CT scan

Background: Ovarian cancer causes more deaths than any other cancers of the female reproductive system. The present study was conducted to assess lesions of ovary using CT scan. Materials & Methods: The present study was conducted 68 females presented to department. Patients were subjected to complete haemogram, erythrocyte sedimentation rate and viral markers. All of them were subjected to contrast enhanced CT scan of abdomen and pelvis with 16-slice Siemens Multidetector CT scan machine. Results: Age group 0-10 years had 6, 20-30 had 24, 30-40 had 21, 40-50 had 4 and >50 years had 3 patients. The difference was significant ( P< 0.01). Common lesions were hemorrhagic cyst in 16, mucinous cystadenoma in 12, tuboovarian abscess in 10, mature cystic teratoma in 8, simple cyst in 7, PCOD in 5, serous cystadenoma in 4 and endometrioma in 6. The difference was significant ( P< 0.05). Common findings were pain in 66, mass in 62, backache in 45, menstrual irregularity in 58, dysmenorrhea in 47, weight loss in 36 and infertility in 11. The difference was significant ( P< 0.05). Conclusion: Authors found that common lesion seen in females were hemorrhagic cyst, mucinous cystadenoma, tuboovarian abscess, mature cystic teratoma, simple cyst, PCOD
Genetic variation of mt DNA-Cyt b gene in three populations of Plagiognathops microlepis

Genetic variations of three populations(Liangzi Lake population of 19,Longwo Lake population of 19 and Huaihe River population of 18) of Plagiognathops microlepis were studied by sequence analysis of mitochondrial cytochrome b(Cyt b) gene.Gene fragments of 1149bp were acquired by PCR and DNA sequencing techniques.There were 10 haplotypes,116 nucleotide variable sites and 10.09% of nucleotide polymorphic loci among three populations of Plagiognathops microlepis.As a base composition,the content of A+T(about 57%) was obviously higher than that of C+G.Highest nucleotide diversity was observed in Huaihe River population(5 haplotypes,111 nucleotide variable sites and 0.031223 of nucleotide diversity index),and lowest nucleotide diversity was detected in Longwo Lake population(3 haplotypes,2 nucleotide variable sites and 0.000550 of nucleotide diversity index). Genetic distances between populations of Liangzi Lake and Longwo Lake,between populations of Huaihe River and Liangzi Lake,and between populations of Huaihe River and Longwo Lake were 0.001530,0.084682 and 0.084335,respectively.There was a closer genetic relationship between populations of Liangzi Lake and Longwo Lake than that between populations of Huaihe River and the other two.Genetic difference between populations of Liangzi Lake and Longwo Lake has not risen to subspecies level,while genetic divergence between populations Huaihe River and Liangzi Lake and between populations Huaihe River and Longwo Lake may have arrived at subspecies level.
Investigating Dimensions of Stiffness in Rheumatoid and Psoriatic Arthritis: The Australian Rheumatology Association Database Registry and OMERACT Collaboration

Objective. It is not known how the experience of stiffness varies between diagnoses or how best to measure stiffness. The aims of our study were to (1) compare stiffness in psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using patient-reported outcomes, (2) investigate how dimensions of stiffness are associated with each other and reflect the patient experience, and (3) analyze how different dimensions of stiffness are associated with physical function. Methods. An online survey was sent to Australian Rheumatology Association Database participants (158 PsA, and 158 age- and sex-matched RA), assessing stiffness severity, duration, impact, importance, coping, and physical function [modified Health Assessment Questionnaire (mHAQ)]. Scores were compared between diagnoses and correlations among stiffness dimensions calculated. Multivariate regression was performed for stiffness severity, impact, and duration on mHAQ, adjusting for age, sex, disease duration, obesity, and pain. Cognitive debriefing was conducted through semistructured telephone interviews. Results. Overall, 240/316 (75.9%) responded [124/158 RA (78.5%) and 116/158 PsA (73.4%)], with no significant difference in stiffness ratings between diagnoses. Scores for all stiffness dimensions were strongly correlated (r = 0.52–0.89), and severity and impact were associated with mHAQ in both diagnoses. Stiffness duration was not associated with mHAQ in RA. In cognitive debriefing, participants described stiffness severity and impact by their effect on daily activities (10/16 and 14/16 participants, respectively). Conclusion. Stiffness ratings were similar between PsA and RA. Different dimensions of stiffness were strongly correlated. Stiffness severity and impact both independently predicted mHAQ. Stiffness was important to participants; however, measuring multiple dimensions of stiffness may have minimal additive value.
Forward attack modes of aquatic feeding garter snakes

Summary 1. Previous studies have suggested that piscivorous snakes generally use sideways head sweeping to capture prey in order to minimize drag on the skull and/or to avoid pushing prey items away from the mouth. However, some aquatic species of garter snakes (genus Thamnophis) have been reported to use fast forward strikes to capture fish and amphibians. To characterize fast forward striking as a mode of piscivory in snakes and compare its use among specialist and generalist species, the aquatic specialists Thamnophis couchii and T. rufipunctatus, and a terrestrial generalist, T. sirtalis, were filmed at 250 fps (frames per second) while preying on minnows. 2. Both T. couchii and T. rufipunctatus oriented visually toward prey items and struck forward rapidly with peak head velocities that approached speeds attained by fast striking booid, colubrid and viperid species on land. In contrast, T. sirtalis did not orient visually toward specific prey items and displayed strikes that were four to six times slower than those of specialist species. 3. Aquatic specialists used moderate amounts of cranial rotation during jaw opening and achieved maximum gape within 20 ms of jaw opening. In the generalist T. sirtalis, jaw opening took 40‐60 ms and was due almost entirely to mandibular rotation. 4. Significant differences in the prey capture kinematics of the two aquatic specialists are consistent with the hypothesis that T. couchii is an open water hunter, whereas T. rufipunctatus is an ambush predator. Thamnophiine snakes display a diversity of aquatic prey capture styles that reflect different behavioral and mechanical solutions to the problem of feeding in water.
Why is it important to use algae in aquaculture

Algae and especially microalgae are very promising into eventual biotechnological applications. Indeed, microalgae are unique compared to other living organisms thanks to their valuable biochemical compounds for aquaculture, human health food, biofuels and other applications. Recently, studies on the oleaginous microalgae, for instance, those from the genus Chlorella , have emerged their uses for commercial exploitations with applications focused on nutrition and aquaculture uses. Chlorella minutissima has outstanding features in health and nutrition; and it could play an important part in aquaculture improvement methods as it produces significant amount of polyunsaturated fatty acids. Microalgae are considered to be among the promising feedstocks for aquaculture in the future. For this end Chlorella minutissima is an oil-rich green alga, was studied in many reports as a source of long chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA) to replace control diet without microalgae for rotifers, which serve in turn as food for early stages of fish.
Relação entre escolhas alimentares e o desenvolvimento de câncer gástrico: uma revisão sistemática

O câncer gastrico e uma patologia de origem multifatorial, que caracteriza-se pela multiplicacao desordenada das celulas que constituem a parede gastrica. Sao considerados importantes fatores de risco,o alcoolismo, o sedentarismo e a infeccao por Helicobacter pylori. No entanto, diversos estudos apontam o consumo alimentar habitual como fator significante no surgimento do câncer de estomago. Neste contexto, este trabalho teve por objetivo realizar uma revisao sistematica da literatura, investigando os achados sobre o presente tema. A identificacao dos artigos foi realizada atraves das bases de dados cientificos PubMed e Scielo, para as estrategias de buscas, foram utilizados os seguintes termos e palavras-chave: "stomach neoplasms", "stomach", "neoplasms", "gastric", "neoplasm gastric", "food". Alem disso, foram utilizados os operadores logicos OR e AND para realizar a combinacao dos termos empregados na busca das publicacoes. Atraves da estrategia de buscas, foram identificadas, inicialmente, um total de 2249 publicacoes nas bases de dados, e, apos a remocao dos duplicados (n=3), 2246 artigos foram selecionados por titulo e resumo. Apos a aplicacao dos criterios de exclusao e leitura dos titulos e resumos, 37 artigos foram selecionados para a leitura do texto completo. Destes, 6 artigos foram selecionados para a revisao sistematica Perante os resultados obtidos, os achados evidenciam que os habitos alimentares erroneos, como o consumo excessivo de alimentos ultra processados, bem como, o modo de preparo destes alimentos, vem sendo apontados com uma relacao positiva para o desenvolvimento de câncer gastrico. No entanto, destaca-se tambem que uma alimentacao variada e equilibrada nutricional mente, com alto consumo de frutas, legumes e verduras e com prevalencia de alimentos in natura, apresenta-se como um fator de protecao contra tal neoplasia.
Progesterone-metabolite prevents protein kinase C-dependent modulation of γ-aminobutyric acid type A receptors in oxytocin neurons

Gonadal steroid feedback to oxytocin neurons during pregnancy is in part mediated via the neurosteroid allopregnanolone (3α-OH-DHP), acting as allosteric modulator of postsynaptic γ-aminobutyric acid type A (GABAA) receptors. We describe here a form of nongenomic progesterone signaling by showing that 3α-OH-DHP not only potentiates GABAA receptor-channel activity but also prevents its modulation by protein kinase C (PKC). Application of oxytocin or stimulation of PKC suppressed the postsynaptic GABA responses of oxytocin neurons in the absence, but not in the presence of 3α-OH-DHP. This finding was true at the juvenile stage and during late pregnancy, when the GABAA receptor is sensitive to 3α-OH-DHP. In contrast, after parturition, when the GABAA receptors expressed by oxytocin neurons are less sensitive to 3α-OH-DHP, this neurosteroid no longer counteracts PKC. The change in GABAA-receptor responsiveness to 3α-OH-DHP helps to explain the onset of firing activity and thus the induction of oxytocin release at parturition.
A second species of Brasilotyphlus (Amphibia: Gymnophiona: Caeciliidae) from Brazilian Amazonia

Brasilotyphlus is rediagnosed in light of the discovery of a second species of the genus, B. guarantanus sp. nov., in the municipality of Guaranta do Norte, state of Mato Grosso, Brazil. The new species differs from B. braziliensis mainly in annular counts, having 151–170 primaries and at most 2 secondaries (instead of 142–147 primaries and 23–36 secondaries).
Ausencia de anfibios en bromelias de tanque en la Estación Biológica San José, Chiapas, México

The current population decline of amphibians, mainly due to habitat destruction and alteration by humans, is alarming. From March to May 2017, we searched for amphibians in terrestrial and arboreal bromeliads (>20cm in height) in 16ha of pine-oak forest. Out of 3 467 bromeliads, only two specimens had amphibians, indicating a devastating population decline.
Autonomous mobile platform with simultaneous localisation and mapping system for patrolling purposes

This work describes an autonomous mobile platform for supervision and surveillance purposes. The system can be adapted for mounting on different types of vehicles. The platform is based on a SLAM navigation system which performs a localization task. Sensor fusion including laser scanners, inertial measurement unit (IMU), odometry and GPS lets the system determine its position in a certain and precise way. The platform is able to create a 3D model of a supervised area and export it as a point cloud. The system can operate both inside and outside as the navigation algorithm is resistant to typical localization errors caused by wheel slippage or temporal GPS signal loss. The system is equipped with a path-planning module which allows operating in two modes. The first mode is for periodical observation of points in a selected area. The second mode is turned on in case of an alarm. When it is called, the platform moves with the fastest route to the place of the alert. The path planning is always performed online with use of the most current scans, therefore the platform is able to adjust its trajectory to the environment changes or obstacles that are in the motion. The control algorithms are developed under the Robot Operating System (ROS) since it comes with drivers for many devices used in robotics. Such a solution allows for extending the system with any type of sensor in order to incorporate its data into a created area model. Proposed appliance can be ported to other existing robotic platforms or used to develop a new platform dedicated to a specific kind of surveillance. The platform use cases are to patrol an area, such as airport or metro station, in search for dangerous substances or suspicious objects and in case of detection instantly inform security forces. Second use case is a tele-operation in hazardous area for an inspection purposes.
Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82

Purposes. To clone and sequence the cDNA for Lp85 calpain from young rat lens, and to test for Lp85 protein expression and proteolytic activity. Methods. RT-PCR and molecular cloning were performed on total RNA from 12 day-old rats. Lp85 protein expression was visualized by immunoblotting using a specific antibody developed to the unique peptide sequence in Lp85. Proteolytic activity was assessed by casein zymography. Transient expression of Lp85 and previously characterized lens-specific calpain Lp82 were separately performed in mammalian COS-7 cells. Results. The 2410-bp cDNA for rat lens Lp85 encoded a protein of 737 amino acid residues with a calculated molecular weight of 85.0 kDa and a predicted pI of 5.67. The amino acid sequence of Lp85 was identical to Lp82 except for an insert region of 28 amino acids in domain IV of the calcium-binding region. mRNA and protein for Lp85 were present only in rat and mouse lenses and not in other tissues or species. Lp85 protein concentrations were highest in the nuclear region, most concentrated in the insoluble fraction, disappeared with lens maturation, and Lp85 exhibited migration similar to Lp82 on native PAGE gels. Lp85 was enzymatically active when expressed in COS-7 cells. Conclusions. Lp85 is a newly classified, lens- and rodent-specific, enzymatically active, member of the AX1 (alternative exon 1) subclass of calpains. In conjunction with Lp82 and m-calpain in lens, Lp85 may be responsible for proteolysis during normal lens development and maturation or during cataract formation in young rodents.
Preparation of monoclonal antibody against okadaic acid and establishment of ciELISA for detecting its residues

A hybridoma cell line secreting monoclonal antibody against okadaic acid(OA) was established after immunization of BALB/c mice with artificially synthesized OA-bovine serum albumin(OA-BSA) as antigen.A fast,sensitive and convenient indirect competitive enzyme linked immunosorbent assay(ciELISA) was set up.The standard curve for OA showed good linearity over the concentration range of 0.3125~20 ng/mL.The equation of linear regression was y=-0.3949x+0.6312. The coefficient correlation of the method was R2=0.9806. The concentration limit to OA was 0.175 ng/mL.The intra-assay and inter-assay CVs were 2.09% and 3.27%,respectively.And the recovery of sample being added OA were 74.2%～80.8%. The ELISA method had 51.82% cross-reactivity with Dinophysistoxin,but there was no cross-reactivity with Saxitoxin.So the ciELISA established in the study could be used to detect OA residues in Shellfish.
Flavonoid Glycosides from Clausena excavata

A new flavonoid glycoside, 3^, 4^-dimethoxy-5, 7, 5^-trihydroxyl-flavone 3-O-alpha-L-rhamnopyranoside (1) and four known flavonoid glycosides were isolated from the aerial part of clausena excavata (Rutaceae), collected from Xishuangbanna, Yunnan, P R China. The ~(13)C NMR assignments for the C6 and C8 of the four known compounds 2-5 were revised by means of 2D NMR experiments.
Research Progresses in Chromosome Doublings of Medicinal Plants

Medicinal polyploid plants attract great attention because of their gigantic organs,high yields and important medicinal and economic values.The paper mainly deals with the chromosome-doubling method and mutagen types for medicinal plants and other factors affecting chromosome doubling.In addition,it introduces the characteristics and identification methods of medicinal plants,and latest achievements obtained in chromosome doubling of medicinal plants in recent years.
Using a Kinect Sensor to Design and Implement an In-Home Rehabilitation System

A stroke, which is a type of brain injury, often has negative effects on moving, talking, or thinking. Therefore, stroke victims should get in a physical rehabilitation process. The rehabilitation process is performed in a rehabilitation center. However, doing exercises at home is more convenient for patients and the cost is low. In this work, a mobile robot is used to develop a physical rehabilitation system based on a Kinect sensor. Moreover, the proposed system combined with a proposed person following system, so the robot is able to track and follow patients.
Rab28 is localised to photoreceptor outer segments, regulates outer segment shedding but is not linked to retinal degeneration in zebrafish

The photoreceptor outer segment is the canonical example of a modified and highly specialised cilium, with an expanded membrane surface area in the form of discs or lamellae for efficient light detection. Many ciliary proteins are essential for normal photoreceptor function and cilium dysfunction often results in retinal degeneration leading to impaired vision. Herein, we investigate the function and localisation of the ciliary G-protein RAB28 in zebrafish cone photoreceptors. CRISPR-Cas9 generated rab28 mutant zebrafish display a reduction in shed outer segment material in the RPE at 1 month post fertilisation (mpf), but otherwise normal retinal structure and visual function up to 12 mpf. Cone photoreceptor-specific transgenic reporter lines show Rab28 localises almost exclusively to outer segments, independently of nucleotide binding. Co-immunoprecipitation analysis demonstrates tagged Rab28 interacts with components of the phototransduction cascade, including opsins, Phosphodiesterase 6C and Guanylate Cyclase 2D. Our data shed light on RAB28 function in cones and provide a model for RAB28-associated cone-rod dystrophy.
Ovarian Follicular Dynamics in Caqueteño Creole Cattle Breed at the Colombian Amazon Piedmont

Caqueteno creole cattle breed is part of the eight Colombian creole cattle breeds. These breeds are characterized by having great adaptive potential to the environmental conditions in which they are found and allowing them greater productive efficiency. Caqueteno creole cattle is a breed in danger of extinction according to parameters referenced by FAO, since it is a population of cattle made up of fewer than 350 individuals. This situation suggests the development of multiple research activities with a reproductive focus to efficiently implement biotechnologies and increase the number of animals. Moreover, this investigation included in the process with n = 10 reproducibly viable multiparous females were used, estrous was synchronized and the transrectal ultrasonography was performed during 27 consecutive days every 24 h (8:00 h) with DP 10 Mindray®, equipped with 7.5 MHz linear transducers. Ninety percent of the sampled population (9/10) responded to the synchronization protocol, of which n = 3 females showed two follicular waves during their Estrous Cycle (EC), with a duration of 20±0.6 days. Meanwhile, that n = 6 females presented three follicular waves during the 22±0.5 days of their EC. The Corpus Luteum (CL) stays a few days longer (19±0.96 days) in individuals of three waves, while in the two lasts until day (17±1). In conclusion, the cows of the Caqueteno creole cattle breed tend to present three follicular waves during EC, having an impact on the increase of the interovulatory interval.
The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling

ABSTRACT Sonic hedgehog (Shh) signal transduction specifies ventral cell fates in the neural tube and is mediated by the Gli transcription factors that play both activator (GliA) and repressor (GliR) roles. Cilia are essential for Shh signal transduction and the ciliary phosphatidylinositol phosphatase Inpp5e is linked to Shh regulation. In the course of a forward genetic screen for recessive mouse mutants, we identified a functional null allele of inositol polyphosphate-5-phosphatase E (Inpp5e), ridge top (rdg), with expanded ventral neural cell fates at E10.5. By E12.5, Inpp5erdg/rdg embryos displayed normal neural patterning and this correction over time required Gli3, the predominant repressor in neural patterning. Inpp5erdg function largely depended on the presence of cilia and on smoothened, the obligate transducer of Shh signaling, indicating that Inpp5e functions within the cilium to regulate the pathway. These data indicate that Inpp5e plays a more complicated role in Shh signaling than previously appreciated. We propose that Inpp5e attenuates Shh signaling in the neural tube through regulation of the relative timing of GliA and GliR production, which is important in understanding how the duration of Shh signaling regulates neural tube patterning. Highlighted Article: Inositol polyphosphate-5-phosphatase E attenuates sonic hedgehog signal transduction through a combination of positive and negative regulatory roles that likely control the relative timing of Gli processing.
Altered visual population receptive fields in human albinism

Albinism is a congenital disorder where misrouting of the optic nerves at the chiasm gives rise to abnormal visual field representations in occipital cortex. In typical human development, the left occipital cortex receives retinal input predominantly from the right visual field, and vice-versa. In albinism, there is a more complete decussation of optic nerve fibers at the chiasm, resulting in partial representation of the temporal hemiretina (ipsilateral visual field) in the contralateral hemisphere. In this study, we characterize the receptive field properties for these abnormal representations by conducting detailed fMRI population receptive field mapping in a rare subset of participants with albinism and no ocular nystagmus. We find a nasal bias for receptive field positions in the abnormal temporal hemiretina representation. In addition, by modelling responses to bilateral visual field stimulation in the overlap zone, we found evidence in favor of discrete unilateral receptive fields, suggesting a conservative pattern of spatial selectivity in the presence of abnormal retinal input. Highlights We characterized population receptive fields in albinotic participants with no ocular nystagmus Confirmed overlapping representations of left and right visual fields in cortex Detected nasal bias in receptive field location for temporal hemiretina representation Evidence in favor of discrete unilateral receptive fields and against double coding