Miracle-dz/UniFAR-FTUs huggingface dataset:
A Single Therapeutic miRNA Rescues the Oncolysis of Androgen Activated Prostate Specific Virus in Androgen Independent Cell Model

Prostate specific conditionally replicating adenoviruses (CRAd) are made by placing a tissue specific promoter upstream of one or more of the viral genes required for replication (e.g., E1A, E1B). However, one major problem associated with these vectors is their dependency for androgen receptor (AR), to transactivate the immediate early gene of the virus. This absolute necessity of androgens for prostate specific promoters renders them less useful in patients that have undergone or are currently on total androgen ablation therapy. Therefore, an alternative approach is needed for the existing vectors to be useful in clinical settings. To overcome this problem, we have generated a prostate specific CRAd by introducing a single therapeutic miRNA (miR-34c) that was identified in our library screen to synergize with viral oncolysis. Overexpression of miR-34c from the backbone of virus not only helped in suppressing the proliferation of AR positive cells but also rescued the oncolysis of androgen activated prostate specific virus in androgen independent cell model. To our knowledge this is the first report describing the utility of a single therapeutic miRNA construct to rescue viral oncolysis in advanced androgen resistant AR negative prostate cancer cell line model.
Investigation of antiradical activity of Salvia officinalis L., Urtica dioica L., and Thymus vulgaris L. extracts as potential candidates for a complex therapeutic preparation

The aim of this study was to investigate free radical-scavenging activity of Salvia officinalis L. ,Thymus vulgaris L. , Urtica dioica L. extracts and mixture of extracts, and to evaluate the effect of these extracts on the ability of mitochondria to generate free radicals. The evaluation of the activity of extracts using 2,2-diphenyl-1-picrylhydrazyl (DDPH), 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radicals scavenging assays and tyrosine nitration inhibition (TNI) techniques showed that thyme extract had the strongest free-radical-scavenging activity. This extract was also found to contain the highest amount of phenols. Mixture of extracts showed slow and identical DPPH and ABTS radical-scavenging activity, with the strongest activity demonstrated during the first minute. Investigation of the ability of extracts to neutralize hydrogen peroxide showed that the lowest extract amount used (0.01 mg) neutralized 24 to 50% and the highest amount (0.1 mg) – 72 to 88% of H2O2. In all cases, thyme extract, had the strongest antioxidant effect. Rat liver mitochondria incubated with 0.1 mg of extracts generated by 45 to 55% less radicals than control mitochondria did. Mitochondria incubated with 1 mg of extracts generated smaller amounts of ROS than incubated with 0.1 mg of extract – in case of thyme extract or even more – in case of stinging nettle or sage extracts. Key words: Salvia officinalis L. , Thymus vulgaris L. , Urtica dioica L. , antioxidant activity.
Long-Term Creep Behavior of Flax/Vinyl Ester Composites Using Time-Temperature Superposition Principle

Natural fibers have great potential to be used as reinforcement in composite materials. Cellulose, being a critical constituent of natural fibers, provides unquestionable advantages over synthetically produced fibers. Increasing demand for use of bio-based composites in different engineering and structural applications requires proper test methods and models for predicting their long-term behavior. In the present work, the time-temperature superposition principle was successfully applied to characterize creep behavior of flax/vinyl ester composites. The creep compliance vs time curves were determined and shifted along the logarithmic time axis to generate a master compliance curve. The time-temperature superposition provided an accelerated method for evaluation of mechanical properties of bio-based composites, and the results suggest that the time-temperature superposition is a useful tool for accelerated testing of long-term behavior of bio-based composites.
Empowerment of Managers and Project Group in Project-Cantered Organizations

In changeable environmental and quick technologic changes, performing activities of organizations should follow more paces to gain the ability of adaptability and improving amongst competitors. As a result, project activities which are quicker become more crucial. Furthermore, for organizations which are related to project performing or planning, following new project management is inevitable. According to current situation and wonderful changes, the most effective method for new project management is making human resource more effective and empowered. In the article, after defining project, project management, project-centered organizations, the reasons of organizations in being project-centered, empowerment, influencing factors and objectives of that, preparations, plans and obstacles of performing empowerment in project-centered organizations are discussed. Eventually, the methods of performing managers and project group empowerment are offered. Also, a conceptual model which is included main factors of empowerment is suggested.
Elliptic differential operators on noncompact manifolds

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GENOTYPE BY ENVIRONMENT INTERACTIONS FOR SEED YIELD AND OIL CONTENT IN SUNFLOWER (H. annuus L.) USING AMMI MODEL

SUMMARY Stability of 25 new sunflower hybrid combinations was compared against three standard hybrids in three locations. Seed yield per unit area and oil content in seed were measured using AMMI analysis. The tested combinations showed significant variations in seed yield (t ha-1) and oil content in seed (%) from one location to another and within individual locations. Variations in seed yield were mostly due to the impact of location, while the variations in oil content were prevalently due to genotypic differences among the hybrids. The highest and lowest average total yields were obtained by the hybrids G20 and G1, respectively. The hybrids G17, G8, G2 and G21 showed the widest adaptability. Slightly narrower adaptability was exhibited by the hybrids G4, G7, G13, G14, etc. The hybrids G6, G16, G15 and G22 showed the narrowest adaptability, i.e., they were considerably affected by the analyzed interactions. The highest and lowest average oil contents were recorded in the hybrids G23 and G28, respectively. The hybrids G7, G11 and G23 demonstrated the highest adaptability for oil content in seed. The lowest adaptability was demonstrated by the hybrids G1 and G16.
Influence of food on the birth rate of the population in the Republic of Macedonia

In the hierarchy of needs, food is the most important, while the people with their existence, knowledge, skills and creativity are irreplaceable realizators of the success of any activity, any enterprise and any country. Statistical data indicate that during the last two or three decades the birth rate in the Republic of Macedonia has declined. The most significant biological factors show that in 1981 the number of live births in Republic of Macedonia was 39,488, in 2001 it was 27,010 and in 2011 the number of live births was 22,270. On the other hand, the area of cultivated land is declining; in 1981 it was 644 thousand hectares, in 2001 - 612 thousand hectares and in 2011 - 511 thousand hectares. According to the data of the State Statistical Office, the total number of livestock decreased; in 1981 it was 431 thousand heads, in 2001-274 thousand heads and in 2011 - 296 thousand heads of livestock. Hence, the data show that in the last decades the number of newborn children has been continuously declining and at the same time the area of cultivated land and the number of livestock have been decreasing. The coefficients of the correlation between cultivated land and birth rate on the one hand, and between livestock and birth rate on the other are quite high. The correlation coefficients are r = 0.87 and r = 0.86 respectively, while the determinations of these variables are 76% and 74%. This paper will discuss the development trends of some vegetable crops, as they are: wheat, corn and grapes, as well as some animal products, such as: cow’s milk, meat and eggs and their impact on population growth.In the empirical part we use VECM model, to investigate cointegration relationship between variables.
A Effective Model Approach for Software bug Triage using Data reduction Techniques

— Bug analysis and eradication is vital process in software enhancement. Numerous small overlooked bugs give rise to untraceable software failures. Bug triage is an vital phase in software correction. In this phase major objective is to assign a programmer to new defect for future analysis. Today major challenge faced by IT firms is huge cost and time on bug analysis manually. Currently to overcome this challenge two methodologies exists with automated bug analysis namely text classification and binary classification. This article presents model survey on Bug triage domain finding issues and techniques that are currently present and their short coming. Proposed bug triage is handled with data reduction which is outcome of feature extraction and example selection algorithm. Survey has been presented on ten articles and problem definition is been define. The research is been implemented for finite dataset and evaluated on efficiency parameters. Graphical analysis present effectiveness of proposed system.
Comparative Study of the Antiproliferative Effect of Kohlrabi and Green Cabbage on Colorectal Cancer Cell Lines

Experimental studies showed that phytochemicals from Brassicaceae Cruciferae vegetables possess anticarcinogenic properties. This association is attributed to glucosinolates molecules, mainly isothiocyanates and indoles released upon consumption of these vegetables. Two members of this family, namely cabbage (Brassica oleracea, group Capitata) and kohlrabi (Brassica oleracea, group Gongylodes) seem to share similar anticarcinogenic characteristics. The aim of this study is to compare the effect of the ethanolic extracts of the edible parts of these two plants on the proliferation and apoptosis of HT-29 and Caco-2 colorectal cancer cell lines. The cytotoxicity of the extracts was assayed using the Trypan Blue Exclusion method and the IC50 was determined to be higher in kohlrabi compared to cabbage. Consequently, WST-1 assay was used to assess the effect of these plant extracts on the proliferation of colorectal cancer cell lines: both extracts exhibited a sharp antiproliferative effect in a dose and time dependent manner, even though the cell viability recorded upon kohlrabi treatment was slightly higher. Analysis of cell DNA content by flow cytomtery revealed the ability of both kohlrabi and cabbage extracts to induce cell cycle arrest in HT-29 cells at the G phase and S phase in similar patterns. Furthermore both extracts promoted apoptosis in colorectal cancer cell lines, as revealed by Cell Death ELISA Assay, as well as Annexin/PI staining followed by flow cytometry analysis. The apoptotic pathway seems to involve the pro-apoptotic protein Bax and the anti-apoptotic protein Bcl-2: the expression of these apoptotic regulatory proteins was altered upon cabbage and kohlrabi treatments in a dose-dependent manner, with a slightly higher increase in the Bax/Bcl-2 ratio upon treatment with cabbage extract. As a conclusion, kohlrabi should be considered, like cabbage, among the potent anti-carcinogenic cruciferous vegetables.
MIDDLE-LATE PLEISTOCENE EVOLUTION OF THE ADRIATIC COASTLINE OF SOUTHERN APULIA (ITALY) IN RESPONSE TO RELATIVE SEA-LEVEL CHANGES

The Adriatic coastal area stretching from Monopoli to Brindisi in i Apulia is characterised by landforms and marine/coastal deposits of Midi dle-Upper Pleistocene age. An E-W striking fault system, roughly corret sponding to the geographic "Soglia Messapica", is also present. This area shows the effects of different phases of coastal evolution. During the Middle Pleistocene, north of the Soglia Messapica, thin coastal deposits accumulated and abrasion surfaces were cut whereas, to the south, marine sediments were deposited. During the last interglacial period, two
Zero sound and first sound in a disk-shaped normal Fermi gas

We study the zero sound and the first sound in a dilute and ultracold disk-shaped normal Fermi gas with a strong harmonic confinement along the axial direction and uniform in the two planar directions. Working at zero temperature we calculate the chemical potential $\ensuremath{\mu}$ of the fermionic fluid as a function of the uniform planar density $\ensuremath{\rho}$ and find that $\ensuremath{\mu}$ changes its slope in correspondence to the filling of harmonic axial modes (shell effects). Within the linear response theory, and under the random phase approximation, we calculate the velocity ${c}_{s}^{0}$ of the zero sound. We find that also ${c}_{s}^{0}$ changes its slope in correspondence of the filling of the harmonic axial modes and that this effect depends on the Fermi-Fermi scattering length ${a}_{F}$. In the collisional regime, we calculate the velocity ${c}_{s}$ of first sound showing that ${c}_{s}$ displays jumps at critical densities fixed by the scattering length ${a}_{F}$. Finally, we discuss the experimental achievability of these zero sound and first sound waves with ultracold alkali-metal atoms.
DESIGN OF A NOVEL BROADBAND EMC DOUBLE RIDGED GUIDE HORN ANTENNA

An improved double ridged horn antenna (DRHA) is proposed in this paper. By adding the dielectric lens at the aperture of the horn, radiation pattern distortion arising in the high frequency band of conventional DRHA is improved, which leads to higher radiation gain. Meanwhile, ridge slot loading contributes to better impedance matching characteristic, broadening the impedance bandwidth e-ciently. The improved antenna is fabricated and measured, with the measured results consist with the simulation perfectly, which proved the viability of the improvement.
Design Approaches to Improve Organic Solar Cells

Organic solar cells (OSC)s are valuable economical and environmental friendly devices capable to generate electricity from sunlight. This is because of their simple fabrication process and minimal material usage in comparison to the inorganic solar cells. OSCs have not been widely commercialized yet because of their relatively low power conversion efficiency and stability problem. It is expected that these obstacles will be surmounted in a foreseeable future upon rigorous research studies performed in the field. This paper is devoted to reviewing the design related strategies that can be taken to enhance OSC performance. These strategies can be accomplished through modulating the architecture of the devices and by considering the alignment of the molecular energy levels between their active layer components.
THE VAKHNENKO EQUATION FROM THE VIEWPOINT OF THE INVERSE SCATTERING METHOD FOR THE KdV EQUATION

The formulation of the inverse scattering transform method is discussed for the nonlinear evolution equation (Ut + 'Uux)x + U = 0 (the Vakhnenko equation). It is shown that the equation system for the inverse scattering problem associated with the Vakhnenko equation can not contain the isospectral Schrodinger equation. The exact two soliton solutions are obtained by means of the use of elements of the inverse scattering problem for the KdV equation.
De Vastgoedlezing 2011: woningcorporaties op een kruispunt: wat zijn de gevolgen van een nieuw evenwicht tussen staatssteun en 'level playing field'?

De Nederlandse woningmarkt functioneert slecht en bezien vanuit de invalshoek van de woningmarkt zijn ingrijpende hervormingen nodig. Corporaties vormen samen met andere beleidsarrangementen een verstorende factor op de woningmarkt. Een herpositionering van corporaties kan een bijdrage leveren aan de gewenste hervorming van de Nederlandse woningmarkt. Beschreven wordt de positie op de woningmarkt, de omvang van de corporatiesector en de vermogenspositie. Als non-profit instelling is er bij de corporatie sprake van vermogen in de dode hand, dan is er geen marktconforme rendementseis. De mate waarin er bij corporaties rendementsverlies is zal aan de orde komen. Sinds 2011 is de staatssteun aan corporaties met nieuwe regelgeving afgebakend, echter nog niet voldoende. Aan de orde komt de rol van de corporaties bij het leveren van een bijdrage aan de vorming van het middensegment in de huursector. Het functioneren van corporaties kan verbeteren door rollen en functies beter te scheiden. Tenslotte worden aanbevelingen gedaan, over de (verlaging) van de staatssteungrens en de vermogenssplitsing.
A macro-perspective on co-creation processes on the Internet

Companies increasingly use open innovation and co-creation processes on the Internet. Despite this rising trend in management, the different forms of open innovation on the Internet have only scarcely been investigated from a macroperspective that systematically categorizes customer-supplier interactions based on a conceptual framework. Using a cross-case study design, we characterize and differentiate six types of customer-supplier processes on the Internet regarding underlying value propositions, value network configurations, and modes of interaction. These co-creation processes can be categorized according to their value propositions that follow different stages of the consumption circle. Each value proposition, as a cohesive element, determines a different value network configuration. We examine how network leaders create different modes of interactions in these value networks that we analyze regarding power, relationship, and coordination mechanisms. Across cases, open innovation on the Internet changes the architecture of the value chain from a single-directed stream to a loop of knowledge exchange that includes almost every vertical stage. Companies therefore cannot assign customer input to a certain functionality but rather must decipher it through interdisciplinary approaches that involve the cooperation of multiple areas. The macro-perspective framework can help companies to identify in which areas they can use open innovation and how to establish co-creation processes in the newly evolving value networks.
Evidences of Thyroid Dysfunction in Case of Nodular Goiter (Ng)

The presence of solitary or multiple nodules including both hot and cold nodules in case of nodular thyroid disease is due to the risk of malignancy, toxicity, and local compressive symptoms. It is characterized by the number of separate lumps (nodules) in the enlarged thyroid gland at the age of puberty. Both hypothyroid and hyperthyroid patients are observed to have abnormal TSH concentrations. The comprehensive survey of 234 patients of nodular goiter carried out and evaluated statistically through chi (Χ2) Calculations in order to investigate various thyroid dysfunctioning based on the normal concentration of thyroid function tests. Hypothyroidism and hyperthyroidism can be accurately diagnosed with laboratory tests performed at Nuclear Medicine, Oncology and Radiotherapy Institute (NORI) Islamabad and other laboratories of Pakistan. The data along with detailed history was collected with the help of clinicians in NORI and entered in the Performa. TSH levels ranging from 0.27-4.2 µIU/ml was considered as normal for the diagnosis in thyroid function tests (TFTs). Chi-square test was used to find the significance of study parameters on categorical scale between two or more groups. The diagnostic evaluation relating to functional and morphological characterization has examined through serum TSH concentration and imaging. Non-significant difference between hypothyroid and hyperthyroid patients of nodular goiter versus control group individuals was observed. The study has concluded that the prevalence of nodular goiter may be dependent on the higher and lower concentration of TSH.
Dual-Hop OSTBC Transmissions Over Fading Channels under Receiver Phase Noise for Regenerative Systems

Space-time coding for fading channels is a Communication technique that realizes the diversity benefits of multiple transmit antennas. Previous work in this area has focused on the narrowband flat fading case where spatial diversity only is available. In this paper, we investigate the use of space-time coding in OFDM based broadband systems where both spatial and frequency diversity are available. We consider a strategy which basically consists of coding across OFDM tones and will therefore be called space-frequency coding. For a spatial broadband channel model taking into account physical propagation parameters and antenna spacing, we derive the design criteria for space-frequency codes and we show that space-time codes designed to achieve full spatial diversity in the narrowband case will in general not achieve full space-frequency diversity. Specifically, we show that the Alamouti scheme across tones fails to exploit frequency diversity. For a given set of propagation parameters and given antenna spacing, we establish the maximum achievable diversity order. Finally, we provide simulation results studying the influence of delay spread, propagation parameters, and antenna spacing on the performance of Space-frequency codes.
Extended spectral response in organic photomultiple photodetectors using multiple near-infrared dopants

We demonstrate highly sensitive polymer photodetectors (OPDs) with spectral response extending from the ultraviolet to the near-infrared (NIR) region (∼1200 nm). After doping two NIR dopants, high external quantum efficiencies (∼5500%) and high responsivities (23.0 A/W) are achieved under a low reverse bias (−3.7 V). The high gains could be attributed to unbalanced carrier transport in the photoactive layer arising from the electron traps at the NIR dopants. This approach allows the ready preparation of OPDs exhibiting broad spectral responses and high quantum efficiencies simultaneously.
Interactive comment on “Towards predictive data-driven simulations of wildﬁre spread – Part I: Reduced-cost Ensemble Kalman Filter based on a Polynomial Chaos surrogate model for parameter estimation”

The paper investigates an interesting direction for the simulation of wildﬁre spread. It relies on data assimilation and polynomial chaos to propose a model/observation coupling adapted to operational constraints. The paper includes many explanations on all aspects of the work: simulation model, data assimilation, polynomial chaos. There is however one key point about the application of the Kalman ﬁlter that is unclear at the moment. See the comments below for further details