Miracle-dz/UniFAR-FTUs huggingface dataset:
Crystallographically Determined Etching and Its Relevance to the Metal-Assisted Catalytic Etching (MACE) of Silicon Powders

Metal-assisted catalytic etching (MACE) using Ag nanoparticles as catalysts and H2O2 as oxidant has been performed on single-crystal Si wafers, single-crystal electronics grade Si powders, and polycrystalline metallurgical grade Si powders. The temperature dependence of the etch kinetics has been measured over the range 5–37°C. Etching is found to proceed preferentially in a 〈001〉 direction with an activation energy of ~0.4 eV on substrates with (001), (110), and (111) orientations. A quantitative model to explain the preference for etching in the 〈001〉 direction is developed and found to be consistent with the measured activation energies. Etching of metallurgical grade powders produces particles, the surfaces of which are covered primarily with porous silicon (por-Si) in the form of interconnected ridges. Silicon nanowires (SiNW) and bundles of SiNW can be harvested from these porous particles by ultrasonic agitation. Analysis of the forces acting between the metal nanoparticle catalyst and the Si particle demonstrates that strongly attractive electrostatic and van der Waals interactions ensure that the metal nanoparticles remain in intimate contact with the Si particles throughout the etch process. These attractive forces draw the catalyst toward the interior of the particle and explain why the powder particles are etched equivalently on all the exposed faces.
Visual-Tactile Speech Perception and the Autism Quotient

Multisensory information is integrated asymmetrically in speech perception: An audio signal can follow video by 240ms, but can precede video by only 60ms, without disrupting the sense of synchronicity (Munhall et al., 1996). Similarly, air flow can follow either audio (Gick et al., 2010) or video (Bicevskis et al., 2016) by a much larger margin than it can precede either while remaining perceptually synchronous. These asymmetric windows of integration have been attributed to the physical properties of the signals; light travels faster than sound (Munhall et al., 1996), and sound travels faster than air flow (Gick et al., 2010). Perceptual windows of integration narrow during development (Hillock-Dunn and Wallace, 2012), but remain wider among people with autism (Wallace and Stevenson, 2014). Here we show that, even among neurotypical adult perceivers, visual-tactile windows of integration are wider and flatter the higher the participant’s Autism Quotient (AQ) (Baron-Cohen et al., 2001), a self-report measure of autistic traits. As “pa” is produced with a tiny burst of aspiration (Derrick et al., 2009), we applied light and inaudible air puffs to participants’ necks while they watched silent videos of a person saying “ba” or “pa,” with puffs presented both synchronously and at varying degrees of asynchrony relative to the recorded plosive release burst, which itself is time-aligned to visible lip opening. All syllables seen along with cutaneous air puffs were more likely to be perceived as “pa. ” Syllables were perceived as “pa” most often when the air puff occurred 50–100ms after lip opening, with decaying probability as asynchrony increased. Integration was less dependent on time-alignment the higher the participant’s AQ. Perceivers integrate event-relevant tactile information in visual speech perception with greater reliance upon event-related accuracy the more they self-describe as neurotypical, supporting the Happé and Frith (2006) weak coherence account of autism spectrum disorder (ASD).
Unilateral Stimulation of Subthalamic Nucleus Does Not Affect Inhibitory Control

Despite the relevance of inhibitory control in shaping our behavior its neural substrates are still hotly debated. In this regard, it has been suggested that inhibitory control relies upon a right-lateralized network which involves the right subthalamic nucleus (STN). To assess the role of STN, we took advantage of a relatively rare model, i.e., advanced Parkinson's patients who received unilateral deep-brain stimulation (DBS) of the STN either of the left (n = 10) or of the right (n = 10) hemisphere. We gave them a stop-signal reaching task, and we compared patients' performance in two experimental conditions, DBS-ON and DBS-OFF. In addition, we also tested 22 age-matched healthy participants. As expected, we found that inhibitory control is impaired in Parkinson's patients with respect to healthy participants. However, neither reactive nor proactive inhibition is improved when either the right or the left DBS is active. We interpreted these findings in light of the fact that previous studies, exploiting exactly the same task, have shown that only bilateral STN DBS restores a near-normal inhibitory control. Thus, although null results have to be interpreted with caution, our current findings confirm that the right STN does not play a key role in suppressing pending actions. However, on the ground of previous studies, it is very likely that this subcortical structure is part of the brain network subserving inhibition but to implement this executive function both subthalamic nuclei must be simultaneously active. Our findings are of significance to other researchers studying the effects of STN DBS on key executive functions, such as impulsivity and inhibition and they are also of clinical relevance for determining the therapeutic benefits of STN DBS as they suggest that, at least as far as inhibitory control is concerned, it is better to implant DBS bilaterally than unilaterally.
Extreme Phenotypes With Identical Mutations: Two Patients With Same Non-sense NHEJ1 Homozygous Mutation

Cernunnos/XLF deficiency is a rare primary immunodeficiency classified within the DNA repair defects. Patients present with severe growth retardation, microcephaly, lymphopenia and increased cellular sensitivity to ionizing radiation. Here, we describe two unrelated cases with the same non-sense mutation in the NHEJ1 gene showing significant differences in clinical presentation and immunological profile but a similar DNA repair defect.
The Inhibition of Phosphoinositide-3 Kinases Induce Resolution of Inflammation in a Gout Model

Phosphoinositide-3 kinases (PI3Ks) are central signaling enzymes that are involved in many aspects of immune cell function. PI3Kγ and PI3Kδ are the major isoforms expressed in leukocytes. The role of PI3K isoforms in the resolution of inflammation is still poorly understood. Here, we investigated the contribution of PI3Kγ and PI3Kδ to the resolution of inflammation in a model of gout in mice. Methods and Results: Experiments were performed in wild-type male C57/Bl6 mice. Selective inhibitors of PI3K-γ (AS605240) or PI3Kδ (GSK045) were injected in the joint 12 h after injection of MSU crystals, hence at the peak of inflammation. Inhibition of either PI3K isoform decreased number of neutrophils that migrated in response to the injection of MSU crystals. This was associated with reduction of myeloperoxidase activity and IL-1β levels in periarticular tissues and reduction of histological score. Joint dysfunction, as seen by reduced mechanical hypernociception, was improved by treatment with either inhibitor. The decrease in neutrophil numbers was associated with enhanced apoptosis and efferocytosis of these cells. There was shortening of resolution intervals, suggesting inhibition of either isoform induced the resolution of neutrophilic inflammation. Blockade of PI3Kγ or PI3Kδ reduced Nuclear Factor kappa B (NF-κB) activation. A pan-PI3K inhibitor (CL27c) reduced inflammation induced by MSU crystals by a magnitude that was similar to that attained by the PI3Kγ or PI3Kδ selective inhibitors alone. Conclusion: Taken together, these results suggest that neutrophils can use PI3Kγ or PI3Kδ to remain in the cavity and blockade of either isoenzyme is sufficient to induce their apoptosis and resolve inflammation in a murine model of gout.
A New Architectural Perspective on Wind Damage in a Natural Forest

Wind damage is a significant driver of forest structure, ecology and carbon cycling in both temperate and tropical regions, but most of the literature on wind damage focusses on conifer plantations. Previous studies in broadleaf forests have been limited by a lack of data on tree architecture, a problem that is potentially overcome by terrestrial laser scanning. Here we apply novel approaches to estimate the critical wind speeds at which trees will break in a temperate, deciduous forest plot in Wytham Woods, UK, using a combination of field data and finite element analysis. Ash trees (Fraxinus excelsior) tend to have lower critical wind speeds than sycamores (Acer pseudoplatanus), while English oak (Quercus robur) are the most mechanically robust. This difference in critical wind speed is driven by tree size and architecture, rather than material properties. We observe a trade-off between critical wind speed and growth rate, both within and across species. Our estimates of critical wind speeds from field data are lower in summer than in winter, emphasizing the importance of the spring and autumn transition periods. Of the three species we studied, those with lower critical wind speeds drop their leaves earlier in autumn, suggesting that the timing of leaf shedding may be under selection pressure to minimize risk of tree damage from winter storms. These results are tentative, but also intriguing and intuitive.
Anticancer Activity in Planctomycetes

There is a strong need to develop new drugs against many severe diseases. Therapy resistance is a major problem in, for instance, infectious diseases and cancer. Drug discovery has again turned to nature to search for molecules that can become drug leads. Although many bacterial phyla are extensively studied, some, like the Planctomycetes, remain largely unexplored as potential sources of new leads. Planctomycetes form a diverse group of bacteria with peculiar characteristics such as division by polar budding and absence of the FtsZ gene. Furthermore, they exhibit large genomes up to 12.5 Mb, and possess a high number of secondary metabolites as assessed by in silico genomic analysis. These characteristics have also revealed the presence of potential anticancer activity. Based on these promising characteristics, we wanted to investigate Planctomycetes as a source for natural products with anticancer properties. Organic and aqueous extracts were obtained from cultivated Planctomycetes strains originated from a variety of habitats such as marine systems (free living or attached to marine algae), deep marine iron hydroxide deposits, brackish water and glacier ice system. The extracts were screened for ability to inhibit cell growth, or induce cell death on two cancer cell lines, the human prostatic cancer cell line PC3, and human acute myeloid leukaemia (AML) cell line MOLM-13, as well as normal rat kidney epithelial cell line (NRK). Out of 39 strains, five exhibited cytotoxicity towards NRK cells, whereas 32 of the strains were toxic to the AML cell line, and four were toxic to the PC3 cell line. Two strains showed high toxicity and selectivity towards both the cancer cell lines over the NRK-cells, and are potential producers of anti-cancer compounds. We found no correlation between bioactivity and strains habitat and geographic location but regarding phylogeny some Rhodopirellula spp. showed higher toxicity toward MOLM-13 cells. These results from the first anticancer screening with Planctomycetes showed that these peculiar microorganisms should be further explored for anti-cancer compounds and that more effort must be put in providing culture collections for drug development purposes.
Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes

Venomous marine snails of the genus Conus employ small peptides to capture prey, mainly osteichthyes, mollusks, and worms. A subset of these peptides known as α-conotoxins, are antagonists of nicotinic acetylcholine receptors (nAChRs). These disulfide-rich peptides provide a large number of evolutionarily refined templates that can be used to develop conopeptides that are highly selective for the various nAChR subtypes. Two such conopeptides, namely [V11L;V16D]ArIB and RgIA4, have been engineered to selectively target mammalian α7∗ and α9∗ nAChRs, respectively, and have been used to study the functional roles of these subtypes in immune cells. Unlike in neurons and cochlear hair cells, where α7∗ and α9∗ nAChRs, respectively, function as ligand-gated ion channels, in immune cells ligand-evoked ion currents have not been demonstrated. Instead, different metabotropic functions of α7∗ and α9∗ nAChRs have been described in monocytic cells including the inhibition of ATP-induced ion currents, inflammasome activation, and interleukin-1β (IL-1β) release. In addition to conventional nAChR agonists, diverse compounds containing a phosphocholine group inhibit monocytic IL-1β release and include dipalmitoyl phosphatidylcholine, palmitoyl lysophosphatidylcholine, glycerophosphocholine, phosphocholine, phosphocholine-decorated lipooligosaccharides from Haemophilus influenzae, synthetic phosphocholine-modified bovine serum albumin, and the phosphocholine-binding C-reactive protein. In monocytic cells, the effects of [V11L;V16D]ArIB and RgIA4 suggested that activation of nAChRs containing α9, α7, and/or α10 subunits inhibits ATP-induced IL-1β release. These results have been corroborated utilizing gene-deficient mice and small interfering RNA. Targeted re-engineering of native α-conotoxins has resulted in excellent tools for nAChR research as well as potential therapeutics. ∗indicates possible presence of additional subunits.
Implicit Perceptions of Closeness From the Direct Eye Gaze

Eye gaze plays an important role during social interaction. Specifically, different eye gaze directions may send different functional messages to the observers, who have the capacity to automatically interpret these signals. In the present study, we used the implicit association test (IAT) to investigate whether direct eye gaze sends a functional, automatically perceived signal about non-target interpersonal closeness. Results suggest that the direct gaze strongly signals close relationship, and this association cannot be accounted for by positive valence. The findings suggest that the direct gaze may function to uniquely communicate a generalized closeness without orientation. Discussion focuses on the implications of these findings for social functions of direct gaze during interpersonal interaction and the automatic nature of such associations.
Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

Pseudomonas aeruginosa is known as an opportunistic pathogen that often causes persistent infections associated with high level of antibiotic-resistance and biofilms formation. Chemical interference with bacterial cell-to-cell communication, termed quorum sensing (QS), has been recognized as an attractive approach to control infections and address the drug resistance problems currently observed worldwide. Instead of imposing direct selective pressure on bacterial growth, the right bioactive compounds can preferentially block QS-based communication and attenuate cascades of bacterial gene expression and production of virulence factors, thus leading to reduced pathogenicity. Herein, we report on the potential of itaconimides as quorum sensing inhibitors (QSI) of P. aeruginosa. An initial hit was discovered in a screening program of an in-house compound collection, and subsequent structure-activity relationship (SAR) studies provided analogs that could reduce expression of central QS-regulated virulence factors (elastase, rhamnolipid, and pyocyanin), and also successfully lead to the eradication of P. aeruginosa biofilms in combination with tobramycin. Further studies on the cytotoxicity of compounds using murine macrophages indicated no toxicity at common working concentrations, thereby pointing to the potential of these small molecules as promising entities for antimicrobial drug development.
Fibroblast Growth Factor 10 and Vertebrate Limb Development

Early limb development requires fibroblast growth factor (Fgf)-mediated coordination between growth and patterning to ensure the proper formation of a functional organ. The apical ectodermal ridge (AER) is a domain of thickened epithelium located at the distal edge of the limb bud that coordinates outgrowth along the proximodistal axis. Considerable amount of work has been done to elucidate the cellular and molecular mechanisms underlying induction, maintenance and regression of the AER. Fgf10, a paracrine Fgf that elicits its biological responses by activating the fibroblast growth factor receptor 2b (Fgfr2b), is crucial for governing proximal distal outgrowth as well as patterning and acts upstream of the known AER marker Fgf8. A transgenic mouse line allowing doxycycline-based inducible and ubiquitous expression of a soluble form of Fgfr2b has been extensively used to identify the role of Fgfr2b ligands at different time points during development. Overexpression of soluble Fgfr2b (sFgfr2b) post-AER induction leads to irreversible loss of cellular β-catenin organization and decreased Fgf8 expression in the AER. A similar approach has been carried out pre-AER induction. The observed limb phenotype is similar to the severe proximal truncations observed in human babies exposed to thalidomide, which has been proposed to block the Fgf10-AER-Fgf8 feedback loop. Novel insights on the role of Fgf10 signaling in limb formation pre- and post-AER induction are summarized in this review and will be integrated with possible future investigations on the role of Fgf10 throughout limb development.
Risk of Heart Failure Hospitalization Associated With Cilostazol in Diabetes: A Nationwide Case–Crossover Study

Background and Objective: It has been suggested to avoid cilostazol, the first-line therapy for peripheral arterial disease, in patients with congestive heart failure (HF). The objective of this study was to evaluate the risk of hospitalization for heart failure (HHF) associated with cilostazol use in the patients of diabetes mellitus. Methods: This case-crossover study retrieved records on diabetic patients > 20 years of age who were hospitalized for heart failure during the period of 2009–2011 from the Taiwan National Health Insurance Database. The “current” period was defined as 1–30 days prior to HHF whereas the 91–120 days prior to HHF served as the “reference” period. The exposure status just preceding the event is compared with exposure of the same person in one or more referent remote to the event. Adjusted odds ratios (OR) were used to estimate time-varying discordant exposure by the ratio of the number exposed to cilostazol only during the case period to the number exposed to cilostazol only during the control period. Results: A total of 47,506 diabetic patients were included in the analysis (average age: 72.7 ± 12.4, percentage of males: 48%). A total of 399 patients (0.84%) received cilostazol only in the current period, and 252 (0.53%) received cilostazol only in the reference period. After adjustment for other medications, a significant association was found between cilostazol and HHF (OR: 1.35, 95% CI: 1.14–1.59). After further adjustment for time-varying co-morbidities the ORs remained essentially the same. Sensitivity analyses using different definitions of control period (ranging from 31–60, 61–90, to 121–150 days before index date) yielded adjusted ORs of 1.43 (95% CI: 1.14–1.79), 1.31 (95% CI: 1.09–1.57) and 1.23 (95% CI: 1.06–1.44), respectively suggesting the robustness of our study findings. Conclusion: Use of cilostazol may be positively related to the risk of HHF. Further studies are warranted to explore the underlying mechanisms and to confirm the association.
V-Fuzz: Vulnerability-Oriented Evolutionary Fuzzing

Fuzzing is a technique of finding bugs by executing a software recurrently with a large number of abnormal inputs. Most of the existing fuzzers consider all parts of a software equally, and pay too much attention on how to improve the code coverage. It is inefficient as the vulnerable code only takes a tiny fraction of the entire code. In this paper, we design and implement a vulnerability-oriented evolutionary fuzzing prototype named V-Fuzz, which aims to find bugs efficiently and quickly in a limited time. V-Fuzz consists of two main components: a neural network-based vulnerability prediction model and a vulnerability-oriented evolutionary fuzzer. Given a binary program to V-Fuzz, the vulnerability prediction model will give a prior estimation on which parts of the software are more likely to be vulnerable. Then, the fuzzer leverages an evolutionary algorithm to generate inputs which tend to arrive at the vulnerable locations, guided by the vulnerability prediction result. Experimental results demonstrate that V-Fuzz can find bugs more efficiently than state-of-the-art fuzzers. Moreover, V-Fuzz has discovered 10 CVEs, and 3 of them are newly discovered. We reported the new CVEs, and they have been confirmed and fixed.
On the non‐asymptotic and sharp lower tail bounds of random variables

The non‐asymptotic tail bounds of random variables play crucial roles in probability, statistics, and machine learning. Despite much success in developing upper bounds on tail probabilities in literature, the lower bounds on tail probabilities are relatively fewer. In this paper, we introduce systematic and user‐friendly schemes for developing non‐asymptotic lower bounds of tail probabilities. In addition, we develop sharp lower tail bounds for the sum of independent sub‐Gaussian and sub‐exponential random variables, which match the classic Hoeffding‐type and Bernstein‐type concentration inequalities, respectively. We also provide non‐asymptotic matching upper and lower tail bounds for a suite of distributions, including gamma, beta, (regular, weighted, and noncentral) chi‐square, binomial, Poisson, Irwin–Hall, etc. We apply the result to establish the matching upper and lower bounds for extreme value expectation of the sum of independent sub‐Gaussian and sub‐exponential random variables. A statistical application of signal identification from sparse heterogeneous mixtures is finally considered.
Theory and Algorithms for Pulse Signal Processing

The integrate and fire converter (IFC) transforms an analog signal into a train of biphasic pulses. The pulse train has information encoded in the timing and polarity of pulses. While it has been shown that any finite bandwidth analog signal can be reconstructed from these pulse trains with an error as small as desired, there is a need for fundamental signal processing techniques to operate directly on pulse trains without signal reconstruction. In this paper, the feasibility of performing online the operations of addition, multiplication, and convolution of analog signals using their pulses train representations is presented. The theoretical framework to perform signal processing with IFC pulse trains imposing minimal restrictions is derived, and algorithms for online implementation of the operators is developed. The performance of the proposed algorithms is studied by quantifying the variations in instantaneous occurrence of pulses. Comparisons are performed with digital processing of reconstructed pulse trains. Moreover, an application of noise subtraction and representation of relevant features of interest in electrocardiogram signal is demonstrated with a sparse data rate of less than 20 IFC pulses per second, and an absolute error in heart rate of 0.16 ± 0.18 bpm.