Miracle-dz/UniFAR-FTUs huggingface dataset:
Temperature‐ and sex‐related effects of serine protease alleles on larval development in the Glanville fritillary butterfly

The body reserves of adult Lepidoptera are accumulated during larval development. In the Glanville fritillary butterfly, larger body size increases female fecundity, but in males fast larval development and early eclosion, rather than large body size, increase mating success and hence fitness. Larval growth rate is highly heritable, but genetic variation associated with larval development is largely unknown. By comparing the Glanville fritillary population living in the Åland Islands in northern Europe with a population in Nantaizi in China, within the source of the post‐glacial range expansion, we identified candidate genes with reduced variation in Åland, potentially affected by selection under cooler climatic conditions than in Nantaizi. We conducted an association study of larval growth traits by genotyping the extremes of phenotypic trait distributions for 23 SNPs in 10 genes. Three genes in clip‐domain serine protease family were associated with larval growth rate, development time and pupal weight. Additive effects of two SNPs in the prophenoloxidase‐activating proteinase‐3 (ProPO3) gene, related to melanization, showed elevated growth rate in high temperature but reduced growth rate in moderate temperature. The allelic effects of the vitellin‐degrading protease precursor gene on development time were opposite in the two sexes, one genotype being associated with long development time and heavy larvae in females but short development time in males. Sexually antagonistic selection is here evident in spite of sexual size dimorphism.
Etude des expressions mimiques conventionnelles francaises dans le cadre d´une communication non verbale testées sur des Hongrois

Un premier article 'Etude des expressions mimiques conventionnelles frangaises dans le cadre d'une communication non verbale' paru dans Semiotica (29-3/4) rend compte d'une experience pratiquee aupres de Frangais. Pour verifier le caractere conventionnel et culturel de ces mimiques, nous les avons parallelement presentees ä un autre public occidental et ä un public asiatique. Voici les resultats obtenus aupres de petits groupes d'etudiants hongrois de Budapest. Pour les personnes n'ayant pas lu le premier article, rappelons brievement le but, la procedure, la methode d'analyse et les resultats de l'experience faite avec des Frangais avant d'etre proposee ä des Hongrois. Comme on se proposait d'etudier les caracteres sur lesquels repose la comprehension des mimiques conventionnelles, on a utilise pour chaque mimique deux versions: une version complete et une version partielle (geste sans visage). Des items ont ete filmes de fa$on ä presenter chaque mimique dans son deroulement complet. Ces items sont 'muets' dans la mesure ou ils ont ete'produits en eliminant au maximum l'articulation de la phrase qui accompagne ordinairement la mimique. Seule demeure, comme indice verbal, dans certains cas, une gestualite labiale intrinseque ä la mimique. Ont ete retenues 34 expressions conventionnelles qui varient en fonction du type de mouvement, en fonction du segment corporel qui supporte le geste ou la mimique, en fonction de la localisation du geste par rapport au corps. Chaque expression a ete filmee simultanement par deux cameras, 1'une enregistrant l'attitude 'globale', l'autre focalisee sur 1'element suppose pertinent. On a ainsi pour chaque mimique deux versions: une version complete et une version partielle. Pour realiser le film, on a utilise des bobines de pellicule noir et blanc 7726 PXTV 16X30M 2R HIT et de l'amorce blanche pour le montage. Le tournage a ete effectue au studio du SERDDAV par Mrs. F. Luxureau et
UvA-DARE ( Digital Academic Repository ) Mucorales between food and infection

Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva. nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.
Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial

The US04 trial was a multicenter, open-label, single arm trial of deferasirox monotherapy (30–40 mg/kg/day) for 18 months. Cardiac iron response was bimodal with improvements observed in patients with mild to moderate initial somatic iron stores; relationship of cardiac response to labile plasma iron is now presented. Labile plasma iron was measured at baseline, six months, and 12 months. In patients having a favorable cardiac response at 18 months, initial labile plasma iron was elevated in only 31% of patients at baseline and no patient at six or 12 months. Cardiac non-responders had elevated labile plasma iron in 50% of patients at baseline, 50% patients at six months, and 38% of patients at 12 months. Risk of abnormal labile plasma iron and cardiac response increased with initial liver iron concentration. Persistently increased labile plasma iron predicts cardiac non-response to deferasirox but labile plasma iron suppression does not guarantee favorable cardiac outcome. Study registered at www.clinicaltrials. gov (NCT00447694).
Position effect variegation and chromatin proteins

Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such rearrangements, the condensed structure of heterochromatin can spread into euchromatic regions, which then assume the morphology of heterochromatin and become transcriptionally inactive. In position‐effect variegation (PEV) therefore, gene inactivation results from a change in chromatin structure. PEV has been intensively investigated in the fruitfly Drosophila, where the phenomenon allows a genetic dissection of chromatin components. Consequently, many genes have been identified which, when mutated, act as dominant modifiers (suppressors or enhancers) of PEV. Data available already demonstrate that genetic, molecular and developmental analysis of these genes provides an avenue to the identification of regulatory and structural chromatin components, and hence to fundamental aspects of chromosome structure and function.
Leadership and entrepreneurial success: a study of SMEs in Malaysia

A review of literature suggests that there is a lack of understanding in regards to leadership behaviours among Malaysian business leaders. This study is significant in providing a clear understanding of this issue. First, the authors aim to investigate the forms of leadership behaviours being practiced by leaders of SMEs in Malaysia and whether these leadership practices are applicable within the scope of Malaysian SMEs. Second, this paper intends to explore whether leadership is important within the context of SMEs in Malaysia. Based on semi-structured interviews, it was found that leadership is important towards the success of entrepreneurial firms. Entrepreneurs who possess effective leadership behaviours tend to enhance their entrepreneurial success. It can be concluded that leaders of SMEs in Malaysia tend to practice more of transformational leadership than transactional leadership qualities and the vast transformation that the country has went through allows for adaptability of western management theories into Malaysian business practices. The originality of this paper lies on being the first to examine the leadership behaviours of Malaysian SMEs from a qualitative perspective.
Mysteries of oxygen and insect size

What sets the maximal size of insects? Results suggest that larger insects invest a greater fraction of their body as respiratory system (tracheal hypermetry). Simple models indicate that tracheal hypermetry prevents increases in PO2 gradients down the tracheae of larger insects. Tracheal hypermetry may lead to spatial constraints within the exoskeleton that provide a maximal limit on insect size. However, this theory must be tested by examination of the world’s largest insects, and examination of the effect of size on tracheal morphology and use of convection. Most insects exhibit developmental plasticity in response to rearing in different oxygen levels, but these plastic effects are likely due to other mechanisms such as direct effects on feeding behavior or downstream effects of oxygen-induced proteins on cell size.
Murine chronic respiratory disease. Significance as a research complication and experimental production with Mycoplasma pulmonis.

bronchiectasis, squamoid changes in bronchial epithelium, and pulmonary abscesses. Demonstration of M pulmonis in these lesions by cultural, ultrastructural and immunofluorescence methods, and the sup-pression of lesions after tetracycline was administered gave confirming evidence of this agent's etiologic role in CRD.
Endoscopic ultrasound-guided fine needle aspiration of pancreatic masses: The utility and impact on management of patients

Abstract Objective. It is controversial whether endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is beneficial in all patients with suspected pancreatic cancer. The aim of this study was to assess diagnostic yield, safety and impact of EUS-FNA on management of patients with solid pancreatic mass. Material and methods. Consecutive patients undergoing EUS-FNA of solid pancreatic mass were enrolled. Gold standard for final diagnosis included histology from surgical resection. In patients without surgery, clinical evaluation methods and repeated imaging studies were used for the comparison of initial cytology and final diagnosis. Patients were followed-up prospectively focusing on subsequent treatment. Results. Among 207 enrolled patients, final diagnosis was malignant in 163 (78.6%) and benign in 44 (21.4%). The sensitivity, specificity and accuracy of EUS-FNA in diagnosing pancreatic cancer were 92.6% (95% CI: 87.20–95.96), 88.6% (95% CI: 74.64–95.64) and 91.8% (95% CI: 87.24–94.81), respectively. No major and five (2.4%) minor complications occurred. Of 151 true-positive patients by EUS-FNA, 57 (37.7%) were surgically explored, of whom 28 (49.1%) underwent resection. Ten of 12 patients with false-negative cytology were explored based on detection of mass on EUS, of whom two had a delay due to false-negative cytology without curative treatment. From the whole study cohort, EUS-FNA had positive and negative impacts on subsequent management in 136 (65.7%) and 2 (0.9%) patients, respectively. Conclusions. EUS-FNA provides accurate diagnosis in 92% and has positive therapeutic impact in two-thirds of patients with solid pancreatic mass. Despite negative cytology, surgical exploration is recommended in clinical suspicion for pancreatic cancer and solid mass on EUS.
De l'utilisation de mesures de confiance en traduction automatique : évaluation, post-édition et application à la traduction de la parole

Cette these de doctorat aborde les problematiques de l'estimation de confiance pour la traduction automatique, et de la traduction automatique statistique de la parole spontanee a grand vocabulaire. J'y propose une formalisation du probleme d'estimation de confiance, et aborde experimentalement le probleme sous le paradigme de la classification et regression multivariee. Je propose une evaluation des performances des differentes methodes evoquees, presente les resultats obtenus lors d'une campagne d'evaluation internationale et propose une application a la post-edition par des experts de documents traduits automatiquement. J'aborde ensuite le probleme de la traduction automatique de la parole. Apres avoir passe en revue les specificites du medium oral et les defis particuliers qu'il souleve, je propose des methodes originales pour y repondre, utilisant notamment les reseaux de confusion phonetiques, les mesures de confiances et des techniques de segmentation de la parole. Je montre finalement que le prototype propose rivalise avec des systemes etat de l'art a la conception plus classique.
An Integrated Approach to Teaching Literature in an EFL Classroom.

This research studied the effectiveness of the integrated approach in English as a Foreign Language (EFL) classrooms and how it related to students’ 1) achievements, 2) critical thinking skills, and 3) attitudes toward reading literature. To ensure that the results were accurate and reliable, the experiment was conducted in two different regions. It was found that the results from both locations were similar. Specifically, the achievement test scores, critical thinking skills improvement, and attitudes toward reading literature of the experiment groups were significantly higher than those of the control groups. This indicated that the integrated approach was effective.
A commedia dell'arte e sua reoperacionalização

Analise da commedia dell’arte a partir de uma perspectiva historico-critica, enfatizando-se as varias maneiras de sua apropriacao no seculo XX.Partindo de elementos da commedia dell’arte, serao ressaltados os temas da migracao do teatro de praca para o teatro fechado e a ampliacao do modelo da commedia dell’arte para outras formas artisticas do seculo XX, como o cinema mudo, o circo e o carnaval.
Magnetization transfer SWIFT MRI consistently detects histologically verified myelin loss in the thalamocortical pathway after a traumatic brain injury in rat

Traumatic brain injury (TBI) is associated with various neurocognitive deficits, and rapid assessment of the damage is potentially important for the prevention and treatment of these deficits. Imaging assessment of mild or moderate damage outside the primary lesion area after TBI, however, remains challenging. Magnetization transfer (MT) has clearly been underutilized in imaging the damage caused by TBI. Here, we applied the MT ratio (MTR) using sweep imaging with Fourier transformation (SWIFT) to study microstructural tissue damage in the thalamocortical pathway outside the primary lesion in a lateral fluid percussion injury rat model of TBI, 5 months after injury. MTR was decreased in layers VIb‐IV of the barrel cortex and related subcortical areas, mainly indicating demyelination, which was verified by histology. The largest MTR change in the cortex was in layer VIb (−8.2%, pFDR = 0.01), and the largest MTR change in the subcortical areas was in the caudal‐most portion of the internal capsule (−11.0%, pFDR < 0.005). These areas exhibited the greatest demyelination and substantial cellularity attributed to gliosis. Correlation analysis of group‐averaged results from the subcortical areas revealed an excellent correlation of MTR with myelin (r2 = 0.94, p < 0.001), but no correlation with increased cellularity as detected by Nissl staining. Thus, MTR using SWIFT can be a valuable tool for the assessment of subtle changes after TBI in both cortical and subcortical areas.
The Austnalian Gentre For Gornputen Enhanced Leanning

The term'Computer Enhanced Learning' (CEL) refers to the utilisation of computers to deepen intellectual understanding of significant ideas by their being used as 'cognitive tools' (Rowe 1.993). By cognitive tools, Rowe means that computing'can provide users with a box of reconstructible tools which can change the characteristics of problems and learning tasks. ' To reinforce the notion of student control over the box of reconstructible tools and the assumption that technology will provide new avenues to human perception and insight, CEL is clearly demarcated from Computer Assisted Instruction (CAI) and the loosely defined generic term of Computer Assisted Leaming (CAL). Computer Enhanced Learning is predicated on the view that the introduction of computing technology into a classroom changes the context of that classroom and enables young people to develop their leaming and thinking skills in different ways from the approaches they use in the absence of the computer. Importantly, as Papert (1985) reminds us, 'If you want to understand (or influence) the change, you have to centre your attention on the culture not on the computer. '
An Input Condition for Teleosemantics? Reply to Shea (and Godfrey‐Smith)1

In his essay "Consumers Need Information: Supplementing Teleosemantics with an Input Condition" (this issue) Nicholas Shea argues, with support from the work of Peter Godfrey-Smith (1996), that teleosemantics, as David Papineau (1987) and I (1984, 2004) have articulated it, cannot explain why "content attribution can be used to explain successful behavior. " This failure is said to result from defining the intentional contents of representations by reference merely to historically normal conditions for success of their "outputs," that is, of their uses by interpreting or consuming mechanisms, bypassing the more traditional focus, of those who would naturalize intentional content, on causal or informational inputs. Shea proposes to "add an input condition to teleosemantics," requiring that simple representations must carry "correlational information. " I am grateful to Shea for his paper, as it presents me with an opportunity to clarify two fairly central features of my position on intentional content, one of which seems to have been overlooked in the literature (Millikan, 1993a), the other of which I have stated previously only in a confusing way (Millikan, 2004, Chapters 3-4). The first clarification concerns the general form that I take explanation by reference to intentional states to have. The second concerns my description of "locally recurrent natural information," why this kind of information is needed in place of Shea's "correlational information" to explain what feeds simple representational systems, and why no reference to natural information is needed to account for the success of behaviors by reference to the truth of representations that motivate them.
ECONOMIC EVALUATION OF COCHLEAR IMPLANT

Objectives: To examine the economic efficiency of current cochlear implant technology under Australian conditions in profoundly deaf adults, partially deafened adults, and children Methods:> Cost—utility study, with weights based on judgments from persons experienced with the technology, and cost data from Australian sources. Results: Quality—of— improvements due to functional consequences of hearing improvement were greater than those due to amelioration of hearing disability. Costs in Australian dollars per QALY (15—year assessment) ranged from $5,070—$11,100 for children, $11,790—$38,150 for profoundly deaf adults, and $14,410—$41,000 for partially deaf adults. Conclusions: Results suggest cochlear implantation is acceptable value for money when compared with other health programs to which resources are committed in Australia.
Substance and procedure in theories of prudential value

In this paper I argue that the debate between subjective and objective theories of prudential value obscures the way in which elements of both are needed for a comprehensive theory of prudential value. I suggest that we characterize these two types of theory in terms of their different aims: procedural (or subjective) theories give an account of the necessary conditions for something to count as good for a person, while substantive (or objective) theories give an account of what is good for a person, given some set of necessary conditions. Characterizing the theories in this way allows us to see their mutual compatibility. To make this case, I assume that a theory of prudential value ought to be descriptively and normatively adequate. The criterion of descriptive adequacy requires that our theory explain the subject relativity of prudential value. I characterize subject relativity in terms of justifiability to subjects and I argue that certain procedural theories are well suited to meet this criterion. The criterion of normative adequacy requires that our theory be capable of guiding action and I argue that a certain kind of substantive theory is needed to meet this requirement.
Effect of Myobacterium bovis (strain Bacillus Calmette-Guérin) on macrophage production by the bone marrow of tumor-bearing mice.

Summary Macrophage production by bone marrow cells is transiently enhanced by either Bacillus Calmette-Guerin or the presence of a growing tumor. At a time when the effect of either has disappeared, the combination of the two results in those cells continuing to produce a significantly greater number of macrophages.
Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men.

BACKGROUND The relation between weight fluctuation and the risk of cardiovascular disease (CVD) is fairly consistent, although the physiologic basis for the relationship is uncertain. In the present study the association between long-term weight fluctuation and the development of metabolic syndrome (MS), a potent CVD risk factor, was investigated. METHODS AND RESULTS A cross-sectional study of 664 Japanese men aged 40-49 years was conducted. The root mean square error around the slope of weight on age (weight - RMSE) was calculated by a simple linear regression model, in which the subject's actual weights at ages 20, 25, 30 years and 5 years prior to the study, as well as current weight, were dependent variables against the subject's age as the independent variable. Weight-RMSE was significantly and positively associated with the prevalence of each MS components (high blood pressure, hypertriglyceridemia, low-high density lipoprotein-cholesterol, high fasting glucose, and obesity). Such associations, as well as clustering of the MS component together with RMSE increase, were apparent among subjects with body mass index (BMI) <25 kg/m2, although the prevalence of MS or its components was much higher among overweight subjects (BMI >or=25 kg/m2). CONCLUSIONS Development of MS possibly explains the risk of CVD not only in overweight or obese persons, but also in normal-weight persons with large weight fluctuation.
Downlink Beamforming Design with Simultaneous Energy and Secure Information Transmission

In this paper, we study a downlink wireless network consisting of wireless powered communication (WPC) system and a simultaneously wireless information and power transfer (SWIPT) systems. The SWIPT system simultaneously serves one information receiver (IR) while transferring power to a wireless device (WD). The wireless powered system consists of the WD and its IR. Both systems operate on the same frequency band. The WD is therefore able to take advantage of the wireless energy transfer from the SWIPT basestation (BS), interference power from the BS due to transmission of signals to IRs and the recycled power for energy harvesting. We aim to minimize the total transmitted power of the SWIPT BS subject to the signal-to-interference-and-noise ratio (SINR) target at the information receivers. In order to preserve the secrecy of the information transmitted by BS to IRs on the BS, we introduce a set of constraints SINR less than one.