Miracle-dz/UniFAR-FTUs huggingface dataset:
Lipid Profile Status in Mustard Lung Patients and its Relation to Severity of Airflow Obstruction

Introduction: Chronic obstructive pulmonary disease (COPD) secondary to sulfur mustard gas poisoning, known as mustard lung, is a major late pulmonary complications in chemical warfare patients. Serious comorbidities like dyslipidemia are frequently encountered in COPD. The aim of this study was to measure the serum lipid profile and evaluate the relation of lipid parameters with the severity of airway obstruction in mustard lung patients. Materials and Methods: Thirty-six non-smoker mustard lung patients with no history of cardiovascular disease, diabetes mellitus, and dyslipidemia were entered into this cross-sectional study. Control group consisted of 36 healthy non-smoker men were considered in this study. Serum lipid profile was performed in the patients and the controls. Spirometry was done in mustard lung patients. Results: The mean age of the patients was 47±6.80 SD years. The mean duration of COPD was 18.50±7.75 SD years. There were statistically significant differences in mean serum triglycerides and total cholesterol levels between patients and controls (p=0.04 and p=0.03, respectively). The mean levels of lipid parameters were not statistically significant different among the 4 stages of COPD severity (p>0.05). Conclusion: The current study revealed that the serum levels of triglycerides and cholesterol are elevated in mustard lung patients compared with the healthy controls. Since lipid profile abnormalities are considered as a major risk factor for cardiovascular disease, especial attention to this matter is recommended in mustard lung patients
Eating Disorders and Addiction: Comparing Eating Disorder Treatment Outcomes Among Clients With and Without Comorbid Substance Use Disorder

&NA; Studies have shown that eating disorders and substance use disorders often co‐occur and share common clinical and biological substrates. Given the high prevalence of co‐occurring eating and substance use disorders, it is important to explore the impact of the dual‐diagnosis on treatment outcomes. The present study compared individuals with an eating disorder only (ED) to those with a comorbid eating and substance use disorder (ED‐SUD) on several factors related to 6‐month post‐treatment outcomes in eating attitudes and behavior and quality of life. Results show that both ED and ED‐SUD clients experience significant improvements in self‐reported eating disorder symptoms and concerns, as well as quality of life functioning. There were no significant differences in outcomes between ED and ED‐SUD clients, which suggests that the two conditions can be successfully treated together.
Evaluación del sistema serológico Febrille Antigen Brucella para la pesquisa de anticuerpos contra brucelas, en Cuba

Introduccion : la brucelosis es una zoonosis perjudicial para la salud humana y veterinaria. Cuba incrementa la ganaderia no controlada productora de alimentos que unida a otras practicas agricolas, inciden en el aumento de la morbilidad por esta enfermedad. La red nacional de laboratorios de salud publica de Cuba, carece de metodos de laboratorio para el diagnostico de la brucelosis humana. Objetivos: evaluar cualitativamente el sistema serologico comercial Febrille Antigen Brucella, para deteccion de anticuerpos contra brucelas, con el uso de sueros de casos y controles. Confirmar la infeccion por brucelas con la aplicacion del sistema serologico comercial para la deteccion de anticuerpos contra brucelas y los sistemas comerciales de referencia ELISA-IgM e IgG, en sueros de pacientes sospechosos de brucelosis. Realizar una descripcion parcial de costos, del sistema serologico comercial Febrille Antigen Brucella. Metodos : se realizo una investigacion en servicios y sistemas de tipo observacional con un estudio de caso control anidado, con cuarenta sueros de casos, 80 controles y 466 muestras de pacientes sospechosos, para evaluar el sistema comercial Febrille Antigen Brucella, (Diagnostic Senese SpA), al que se le efectuo tambien una evaluacion economica parcial de costos. Se utilizaron como pruebas de referencia ELISA-IgM y ELISA-IgG (VIRCELL, Espana). Resultados: el sistema de Febrille Antigen Brucella mostro valores de sensibilidad de 100,00%, especificidad de 97,50 % y una concordancia de 98,33 %. De los 72 casos clinicos, 25 presentaron titulos ≥ 160 por Febrille Antigen Brucella, fueron positivos tambien por ELISA IgM o ELISA IgG. El uso de los sistemas ELISA-IgM e IgG en los sueros reactivos y sospechosos por Febrille Antigen Brucella, incremento la positividad serologica. El costo medio total (21,46 CUP) para una determinacion por Febrille Antigen Brucella resulto economico. Conclusion : el diagnostico de laboratorio de la brucelosis humana en Cuba, se fortalece al demostrar que el Febrille Antigen Brucella tiene un costo economico y que es util para la deteccion de anticuerpos contra brucelas.
Reassessing guidelines for heart failure

Significant progress has been made in the last few years in the management of heart failure. In particular several trials have given significant results. It has become apparent that heart failure may be prevented in some patients by treatment of risk factors such as coronary artery disease. Experience with angiotensin-converting enzyme (ACE) inhibitors has shown that the survival and symptomatic benefits do last in the long term, and confirm that they are the first-line treatment in heart failure. The results of a number of trials using the angiotensin receptor blockers (ARBs) candesartan, valsartan and losartan are presented and discussed. There is also some experience now in the use of candesartan for patients with heart failure and preserved left ventricular systolic function. The COMET trial compared the β-blockers carvedilol and metoprolol tartrate, and suggests that there may be differences in clinical effect between β-blockers. The selective aldosterone receptor blocker eplerenone was evaluated in the EPHESUS trial in post-MI patients with signs of heart failure. Based on these clinical trials, heart failure guidelines are now being updated.
Parkinsonismo: diagnósticos alternativos a la enfermedad idiopática de Parkinson

Parkinsonism is manifested as bradykinesia; tremor with signs and symptoms suggesting Parkinson's disease. The most common cause of Parkinsonism is Idiopathic Parkinson's disease; however, there are other multiple pathologies and situation that have top be considered accordingly in this clinical setting. Since the treatment and outcomes varies widely between these conditions is of paramount importance to work up the Parkinsonism and try to achieve an accurate diagnosis. This review gives a general landscape of Parkinsonism and its most likely differentials.
Human Kallikrein 3 (prostate-specific antigen) and Human Kallikrein 5 Expression in Salivary Gland Tumors

The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus. It has also been shown to be a potential biomarker for breast, ovarian and testicular cancer. Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland. The aim of this study was to determine whether hK3 and hK5 are expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues. Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas and adenocarcinomas not otherwise specified of both minor and major salivary glands were examined. The results of this study indicate that most salivary gland tumors do not show high levels of expression of hK5. Staining was most prominent in keratinizing epithelia in pleomorphic adenomas. hK3 is not expressed in salivary gland tumors. (Int J Biol Markers 2006; 21: 201-5)
Differential Expression Patterns of Irf3 and Irf7 in Pediatric Lymphoid Disorders

Interferon regulatory factors (IRFs) are multifunctional transcriptional factors. To define the role of IRFs in lymphoid disorders, we determined the expression patterns of IRF3 and IRF7 by immunohistochemistry in 5 normal lymph nodes, 12 reactive hyperplastic lymph nodes, and 27 pediatric lymphomas. IRF3 was prominently expressed in the nuclei of the histiocytes, and was expressed very weakly in the cytoplasm of most of the lymphocytes of the normal lymph nodes. However, IRF7 was expressed strongly in the nuclei of over 50% of the lymphocytes throughout the normal lymph nodes, but the histiocytes and fibroblasts were spared. In the reactive hyperplastic lymph nodes, the number of IRF3and IRF7positive cells in the nuclei was elevated. In the lymphomas, the number of IRF3-positive cells in the nucleus appeared to have decreased, and the cells were scattered throughout the lymphoma tissue in no specific pattern. However, in most cases the number of IRF7-positive cells was elevated. These results suggested that IRF3 was activated principally in the histiocytes and T cells under inflammatory conditions, but IRF3 activation was attenuated in cases of lymphoma. However, the number of IRF7-positive cells was found to be elevated in the reactive hyperplastic lymph nodes and pediatric lymphoma. (Int J Biol Markers 2007; 22: 34-8)
Left Internal Mammary Artery Graft Retransplantation from the Recipient to the Donor Heart: A Case Report

Progress in Transplantation, Vol 10, No. 1, March 2000 Case Report A 64-year-old man was referred to the Vanderbilt Heart Transplant Program with a 20-year history of ischemic cardiomyopathy. His history included several myocardial infarctions, necessitating CABG in 1980 and 1988 followed by multiple angioplasties because of recurrent angina pectoris. At the time of referral for transplantation, he required frequent hospitalizations for exacerbations of congestive heart failure and kidney dysfunction due to low cardiac output. He was not a candidate for the regular list because of his age. The history of previous bilateral amputation also constituted a relative contraindication for transplantation. He had no history or clinical evidence of peripheral vasculopathy and had undergone lower extremity amputation in 1988 following his second CABG because of perioperative limb ischemia Left internal mammary artery graft retransplantation from the recipient to the donor heart: a case report
Arginase as a Useful Factor for the Diagnosis of Colorectal Cancer Liver Metastases

The present work is a continuation of studies on arginase as a marker in the diagnosis of colorectal cancer liver metastases (CRCLM). The purpose of the study was the evaluation of the arginase test in comparison with other colorectal cancer tests such as CEA, CA 19-9 and biochemical markers of liver function such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The studies were conducted on blood serum from 85 patients with CRCLM obtained one to two days before tumor resection. The control group comprised 140 healthy blood donors and 81 patients with various non-malignant gastrointestinal diseases. Raised arginase activity was observed in serum of 85% of CRCLM patients, whereas elevated levels of CEA and CA 19-9 were found in 63% and 42% of patients, respectively. The combination of CEA or CA 19-9 with the arginase assay improved their sensitivity, but the sensitivity of the combined parameters was not higher than that of the arginase test itself. AST and ALT activities were increased in about 30% of CRCLM patients. The specificity of the arginase test calculated for 221 control subjects was 76%. It can thus be concluded that the determination of serum arginase activity can be helpful in the diagnosis of patients with colorectal cancer liver metastases. (Int J Biol Markers 2006; 21: 40-4)
Therapy in the elderly hypertensive

The number of people over the age of 65 years continues to increase. In most societies blood pressure (BP) increases with age and elevated levels of BP are common in the elderly.The elderly are also a high-risk group for cardiovascular (CV) disease, which is the leading cause of death in most developed countries. Several intervention trials have confirmed lower CV disease risk in hypertensive patients aged into their early eighties when treated with a variety of antihypertensive drugs. Whilst there is some limited evidence to suggest that -blockers may not be as effective as thiazide diuretics in reducing coronary heart disease (CHD) or total mortality in the elderly, the combination of the two agents and thiazides alone appear to be as effective as newer agents, such as angiotensin-converting enzyme inhibitors (ACE-I) and calcium antagonists. There was no evidence from these trials that BP reduction in the elderly was associated with any deleterious effects. Whilst the benefits of treating the elderly hypertensive are well established, some issues remain to be clarified, particularly in relation to treating the very elderly and the potential benefits beyond BP control that may be afforded by newer antihypertensive agents.
THE LIVER LESION OF THE EPPING JAUNDICE

An outbreak of jaundice in the Epping district, involving at least 84 people, had been traced previously to eating bread made from flour accidentally contaminated with 4,4'-diaminodiphenylmethane. In this paper the clinical, biochemical, and liver-biopsy findings are described. There were three modes of presentation according to presence or absence of upper abdominal pain and its severity, but this could not be correlated with the probable amount of toxin eaten. Rigors, limb pains, malaise, and obstructive jaundice followed. Jaundice sometimes lasted for months. Differential diagnosis included cholelithiasis. Serum bilirubin, serum alkaline phosphatase, and serum aspartate transaminase were raised to a varying and generally moderate degree. In a few cases there was blood eosinophilia. Seven patients had liver biopsies. These showed portal inflammation, eosinophil infiltration, cholangitis, cholestasis, and hepatocellular damage at different stages. Fibrosis appeared to be slight. All patients have now made a good clinical recovery.
Sleep and Daytime Sleepiness of Patients with Left Ventricular Assist Devices: A Longitudinal Pilot Study

among patients with heart failure; in studies reviewed, up to 70% of patients with heart failure had at least 1 sleep complaint. In heart failure, the common reported behavioral and health outcomes affected by sleep disturbance include an exaggeration of psychological distress (eg, anxiety and depression), daytime sleepiness, and a decrease in quality of life. Studies on sleep and sleep disorders among patients with heart failure are extensive. However, very little has been published on sleep among patients with advanced/ end-stage heart failure who have long-term left ventricular assist devices (LVADs) implanted as a bridge to heart transplantation, destination therapy (ie, alternative to a transplant), or a bridge to decision for a specific therapeutic indication. In these patients, too, disturbance in sleep pattern may affect quality of life adjustment after LVAD implantation. The interest in investigating sleep as an important clinical outcome for patients with LVADs has not kept pace with the rapidly expanding indications and technological advancements in mechanical circulatory support. In the past decade, very few investigators have paid attention to sleep in patients with LVADs. Within the few publications, 2 case reports have shown conflicting effects of LVADs in patients with advanced heart failure who have known sleep disorders. In 1 report, polysomnography data of 3 patients showed that sleep-disordered breathing (eg, sleep apnea) persisted 2.5 months (80 days) after LVAD implantation, whereas in the other, 1 patient reported a resolution of sleep apnea at 10 months after LVAD implantation. Moreover, from a “symptom distress” perspective, sleep disturbance was one of the common reported adjustment concerns among hospitalized and communitydwelling LVAD recipients. Sleep and daytime sleepiness of patients with left ventricular assist devices: a longitudinal pilot study
Effectiveness of the metformine in patients with exogenous obesity

A therapeutic intervention was carried out in 12 patients with exogenous obesity, assisted in the Endocrinology Department from "Saturnino Lora Torres" Teaching Clinical Surgical Provincial Hospital in Santiago de Cuba, from July, 2013 to the same month of 2014, who were randomly selected and then assigned into 2 groups of identical quantity of members: a control group which had the diet as the only therapy, and that of study which received diet and metformine as treatment; in order to determine the effectiveness of this drug in the weight loss. The information was analyzed and processed through the hypothesis tests of Mann Whitney and of means comparison, with an error of 5%, and it was obtained that this drug was more effective combined with the diet that the dietary monotherapy as the only treatment.
CHFR Promoter Hypermethylation and Reduced CHFR mRNA Expression in Ovarian Cancer

Background: Ovarian cancer is one of the most common cancers and can be treated with microtubule-targeting drugs. Checkpoint with forkhead and ring finger domains (CHFR) is a protein implicated in cancer sensitivity to microtubule-targeting drugs. Whereas CHFR downregulation, often with CHFR promoter hypermethylation, has been identified in a large number of tumor types, it has not been in ovarian cancer. We therefore searched for CHFR downregulation in primary ovarian tumors. Methods: Fresh ovarian cancer tissues from 53 patients (test) and normal ovarian tissues from 21 patients (control) were tested for CHFR promoter hypermethylation and CHFR mRNA levels. Results: The CHFR promoter was hypermethylated in 20.75% (11/53) of the ovarian cancers and none (0/21) of the normal controls. The normal controls had a mean mRNA level of 1.89 relative fluorescence units (RFU) with a range of 0.04-24.78 RFU. The cancer tissues had a mean mRNA level of 0.77 RFU with a range of 0.00-68.75 RFU. The median value of the cancer group was significantly lower than that of the control group (p=0.0067). Those cancer samples that had hypermethylated CHFR promoters also had low (n=3) or undetectable (n=8) CHFR mRNA levels. Conclusions: In contrast to previous reports, we found that alterations in CHFR mRNA and CHFR methylation can be frequently found in ovarian cancers. CHFR hypermethylation was strongly associated with the loss of CHFR mRNA expression. CHFR downregulation in ovarian tumors may be clinically relevant as a staging biomarker, as an indicator of sensitivity to microtubule-targeting drugs, and as a future drug target. (Int J Biol Markers 2009; 24: 83-9)
Use of Valsartan in Post-Myocardial Infarction and Heart Failure Patients

Left ventricular (LV) dysfunction and/or heart failure (HF) are frequent complications of hypertension and myocardial infarction (MI), placing affected patients at increased risk of significant morbidity and premature death. Given that the renin-angiotensin-aldosterone system (RAAS) is activated and of pathophysiological importance in such patients, a strong therapeutic rationale exists to target the main effector mechanism (that is, angiotensin II [Ang II]) in order to lessen the associated morbidity and mortality burden. Angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce mortality and LV dysfunction and to slow disease progression in patients with HF, including high-risk, post-MI patients. However, ACE inhibitors (ACE-Is) may not provide optimal long-term RAAS blockade (a finding that is associated with a worse prognosis) and many patients are unable to tolerate such therapy (because of troublesome dry cough, for example) In contrast, Ang II receptor blockers (ARBs) may block the RAAS more completely than ACE-Is and appear to be better tolerated. Several large-scale trials have evaluated the efficacy of ARBs in patients with LV dysfunction and/or HF (including high-risk, post-MI patients), and have confirmed their utility as an efficacious and well-tolerated alternative to ACE-Is in this setting.
Regulation of Coagulation Abnormalities and Temperature in Organ Donors

hemorrhage that requires blood transfusion in about 60% of organ donors. Although transplanted organs from donors who demonstrate a significant coagulopathy from disseminated intravascular coagulation (DIC) may function normally, hypovolemic shock, anemia, and reduced oxygen delivery to donor organs may secondarily jeopardize organ function prior to removal. The organ procurement coordinator (OPC) should, therefore, be familiar with clinical assessment and therapy methods for the most common causes of disordered blood coagulation in organ donors.
Letter to the Editors

102 WWW.HERDJOURNAL. COM ISSN: 1937-5867 The life of a healthcare chief executive offi cer (CEO) is not as much fun these days. Th e worst economic nightmare in this generation has arrived. Healthcare costs are out of control and almost everyone agrees that the status quo is untenable. Medicare and Medicaid payments are being cut or frozen. State budgets are in free fall, causing some to delay payments and reduce covered services. No matter what type of healthcare reform is adopted, hospitals must learn to operate more effi ciently.
Long-term survival of stage IV hepatocellular carcinoma treated with multimodal approach

A 42 year old diabetic lady presented with a recent history of ankle swelling and shortness of breath. On further evaluation, she was found to have Child's class A cirrhosis with a model for end stage liver disease score of 9. Liver imaging and echocardiogram showed a typical hepatocellular carcinoma (HCC) in segment VIII of the liver extending into the right hepatic vein, inferior vena cava (IVC) and into the right atrium (Figure 1). There was a secondary thrombus in the IVC. Right atrial inflow and outflow showed features of impending obstruction. Considering her excellent general condition, it was decided to perform a combined thoraco-laparotomy. During laparotomy, the liver had significant macroscopic changes of cirrhosis. We decided to abandon the liver resection and to only remove the atrial tumour to palliate symptoms. The right atrium was opened under cardiopulmonary bypass and the atrial tumour was removed from its origin at the right hepatic vein (Figure 2). A secondary clot in the IVC was also removed.
Clinical Photographs—the Gold Standard

This survey was carried out to allow a minimum data set required for intra- and extra-oral photographs to be established. In 1999 a questionnaire was sent to members of the Angle Society of Europe to establish their current clinical practice with regard to extra- and intra-oral photography. The Angle Society was chosen because of their stated commitment to a high standard of record keeping and of clinical care. Results showed that a full series of extra- and intra-oral photographs were taken both before and after treatment, as well as stage photographs during treatment on many cases. The need for each of these photographs will be discussed in some detail, and recommendations will be made as to what would be considered the Gold standard before, during, and after a course of orthodontic treatment.