Miracle-dz/UniFAR-FTUs huggingface dataset:
Overcoming the ill-posedness through discretization in vector tomography: Reconstruction of irrotational vector fields

Vector tomography methods intend to reconstruct and visualize vector fields in restricted domains by measuring line integrals of projections of these vector fields. Here, we deal with the reconstruction of irrotational vector functions from boundary measurements. As the majority of inverse problems, vector field recovery is an ill posed in the continuous domain and therefore further assumptions, measurements and constraints should be imposed for the full vector field estimation. The reconstruction idea in the discrete domain relies on solving a numerical system of linear equations which derives from the approximation of the line integrals along lines which trace the bounded domain. This work presents an extensive description of a vector field recovery, the fundamental assumptions and the ill conditioning of this inverse problem. More importantly we show that this inverse problem is regularized via the domain discretization, i.e. we show that the recovery of an irrotational vector field within a discrete grid employing a finite set of longitudinal line integrals, leads to a consistent linear system which has bounded solution errors. We elaborate on the estimation of the solution's error and we prove that this relative error is finite and therefore a stable vector field reconstruction is ensured. Such theoretical aspects are critical for future implementations of vector tomography in practical applications like the inverse bioelectric field problem. We validate our theoretical results by performing simulations that reconstruct smooth irrotational fields based solely on a finite number of boundary measurements and without the need of any additional or prior information (e.g. transversal line integrals or source free assumption).
Jugabilidad como medida de calidad en el desarrollo de videojuegos

Los videojuegos se han convertido en un campo de importante avance en el sector interactivo debido a su exito comercial. Estos avances hacen que cada vez sea mas importante analizar si la Experiencia del Usuario es adecuada dependiendo de la naturaleza del videojuego y de esta forma poder asegurar una calidad de uso optima por parte del jugador, factor que puede repercutir en el exito o fracaso de aceptacion de los usuarios. Uno de los factores determinantes en la calidad de uso es la denominada ‘Jugabilidad’. En este trabajo tenemos como principal objetivo extender el nuevo estandar internacional ISO/IEC 25010, 2011 para la Calidad en Uso en base a la jugabilidad para poder analizar el grado de la experiencia interactiva, o grado de calidad desde el punto de vista de la interaccion entre el jugador y juego, en busca de un mejor conocimiento e informacion que ayude a mejorar los procesos de evaluacion y aseguramiento de la calidad del producto final tan demandados en la industria actual.
AD-Miner: A new incremental method for discovery of minimal approximate dependencies using logical operations

Discovery of possible relations between attribute values in a relational database (i.e., functional dependencies) is an important issue in the field of data mining and knowledge discovery. Many search techniques have been proposed to discover classical and extended functional dependencies; but even the most efficient solutions do not have an acceptable performance in the case of large relation instances. In addition, most of the proposed algorithms assume that the database is static and thus database updates require re-scanning of the entire data repeatedly. In this paper, we propose a new incremental method, AD-Miner, to discover Approximate Dependencies (ADs). The main part of our work is based on logical operations which aim to reduce the computational complexity. The method is incremental and thus avoids re-scans of database when a set of tuples is added to the relation. Our experimental results indicate that our method is more efficient than FastFDs [22] which is one of the most efficient algorithms for mining of perfect dependencies. Furthermore, we have shown that the complexity of our method is lower than major incremental methods namely partitioning and Pair-wise comparison methods. In addition, our method has the extra advantage of marking the index of the tuples that violate a dependency. This feature can be used to find the exceptional cases that are inconsistent with the rest of the data. We have implemented AD-Miner and tested it on several benchmarks and synthetic data.
Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy

Background The integration of NIR photothermal therapy and chemotherapy is considered as a promising technique for future cancer therapy. Hollow Prussian nanospheres have attracted much attention due to excellent near-infrared photothermal conversion effect and drug-loading capability within an empty cavity. However, to date, the hollow Prussian nanospheres have been prepared by a complex procedure or in organic media, and their shell thickness and size cannot be controlled. Thus, a simple and controllable route is highly desirable to synthesize hollow Prussian nanospheres with controllable parameters. Materials and Methods Here, in our designed synthesis route, the traditional FeCl3 precursor was replaced with Fe2O3 nanospheres, and then the Prussian blue (PB) nanoparticles were engineered into hollow-structured PB (HPB) nanospheres through an interface reaction, where the Fe2O3 colloidal template provides Fe3+ ions. The reaction mechanism and control factors of HPB nanospheres were systematically investigated. Both in vitro and in vivo biological effects of the as-synthesized HPB nanospheres were evaluated in detail. Results Through systematical experiments, a solvent-mediated interface reaction mechanism was put forward, and the parameters of HPB nanospheres could be easily adjusted by growth time and template size under optimal water and ethanol ratio. The in vitro tests show the rapid and remarkable photothermal effects of the as-prepared HPB nanospheres under NIR laser irradiation (808 nm). Meanwhile, HPB nanospheres also demonstrated a high DOX loading capacity of 440 mg g−1 as a drug carrier, and the release of the drug can be regulated by the heat from PB shell under the exposure of an NIR laser. The in vivo experiments confirmed the outstanding performance of HPB nanospheres in photothermal/chemo-synergistic therapy of cancer. Conclusion A solvent-mediated template route was developed to synthesize hollow Prussian blue (HPB) nanospheres in a simple and controllable way. The in vitro and in vivo results demonstrate the as-synthesized HPB nanospheres as a promising candidate due to their low toxicity and high efficiency for cancer therapy.
Spatial-Frequency Feature Learning and Classification of Motor Imagery EEG Based on Deep Convolution Neural Network

EEG pattern recognition is an important part of motor imagery- (MI-) based brain computer interface (BCI) system. Traditional EEG pattern recognition algorithm usually includes two steps, namely, feature extraction and feature classification. In feature extraction, common spatial pattern (CSP) is one of the most frequently used algorithms. However, in order to extract the optimal CSP features, prior knowledge and complex parameter adjustment are often required. Convolutional neural network (CNN) is one of the most popular deep learning models at present. Within CNN, feature learning and pattern classification are carried out simultaneously during the procedure of iterative updating of network parameters; thus, it can remove the complicated manual feature engineering. In this paper, we propose a novel deep learning methodology which can be used for spatial-frequency feature learning and classification of motor imagery EEG. Specifically, a multilayer CNN model is designed according to the spatial-frequency characteristics of MI EEG signals. An experimental study is carried out on two MI EEG datasets (BCI competition III dataset IVa and a self-collected right index finger MI dataset) to validate the effectiveness of our algorithm in comparison with several closely related competing methods. Superior classification performance indicates that our proposed method is a promising pattern recognition algorithm for MI-based BCI system.
Risk of Suicide Among US Military Service Members Following Operation Enduring Freedom or Operation Iraqi Freedom Deployment and Separation From the US Military.

IMPORTANCE A pressing question in military suicide prevention research is whether deployment in support of Operation Enduring Freedom or Operation Iraqi Freedom relates to suicide risk. Prior smaller studies report differing results and often have not included suicides that occurred after separation from military service. OBJECTIVE To examine the association between deployment and suicide among all 3.9 million US military personnel who served during Operation Enduring Freedom or Operation Iraqi Freedom, including suicides that occurred after separation. DESIGN, SETTING, AND PARTICIPANTS This retrospective cohort design used administrative data to identify dates of deployment for all service members (October 7, 2001, to December 31, 2007) and suicide data (October 7, 2001, to December 31, 2009) to estimate rates of suicide-specific mortality. Hazard ratios were estimated from time-dependent Cox proportional hazards regression models to compare deployed service members with those who did not deploy. MAIN OUTCOMES AND MEASURES Suicide mortality from the Department of Defense Medical Mortality Registry and the National Death Index. RESULTS Deployment was not associated with the rate of suicide (hazard ratio, 0.96; 99% CI, 0.87-1.05). There was an increased rate of suicide associated with separation from military service (hazard ratio, 1.63; 99% CI, 1.50-1.77), regardless of whether service members had deployed or not. Rates of suicide were also elevated for service members who separated with less than 4 years of military service or who did not separate with an honorable discharge. CONCLUSIONS AND RELEVANCE Findings do not support an association between deployment and suicide mortality in this cohort. Early military separation (<4 years) and discharge that is not honorable were suicide risk factors.
HERPES SIMPLEX SKIN LESIONS SIMULATING SMALLPOX.

THE WIDE VARIATION of clinical responses to herpes simplex virus infection is well known. In the present case the skin lesions are unusual and resemble mild smallpox or varioloid. For this reason strict isolation and notification of public health authorities were warranted. Report of a Case A 23-year-old white woman was admitted to a private hospital in Memphis on July 14, 1963, with a chief complaint of pain and itching in the vulvar region. She had been under therapy for chronic granulocytic leukemia, the diagnosis of which had been made four years previously at the birth of her only child. Approximately four weeks prior to admission, the patient went to Chicago where she visited a friend and worked in a plastics factory. The present illness began approximately a week before admission to the hospital when a febrile illness with pain, itching, and excoriation of the skin in the vulvar region
Do Salivary Antibodies Reliably Reflect Both Mucosal and Systemic Immunity?

Abstract: Two major antibody classes operate in saliva: secretory IgA (SIgA) and IgG. The former is synthesized as dimeric IgA by plasma cells (PCs) in salivary glands and is exported by the polymeric Ig receptor (pIgR). Most IgG in saliva is derived from serum (mainly via gingival crevices), although some is locally produced. Gut‐associated lymphoid tissue (GALT) and nasopharynx‐associated lymphoid tissue (NALT) do not contribute equally to mucosal PCs throughout the body. Thus, enteric immunostimulation is an inadequate mode of stimulating salivary IgA antibodies, which are poorly associated with the intestinal SIgA response, for instance after enteric cholera vaccination. Nevertheless, the IgA response in submandibular/sublingual glands is better related to B cell induction in GALT than the parotid response. Such disparity is suggested by the elevated levels of IgA in submandibular secretions of AIDS patients, paralleling their highly upregulated intestinal IgA system. Moreover, in patients with active celiac disease, IgA antibodies to disease‐precipitating gliadin are reliably represented in whole saliva but not in parotid secretion. Parotid SIgA may be more consistently linked to immune induction in palatine tonsils and adenoids (human NALT), as supported by the homing molecule profile of NALT‐derived B cell blasts. Also several other variables influence the levels of antibodies in oral secretions. These include difficulties with reproducibility and standardization of immunoassays, the impact of flow rate, acute or chronic stress, protein loss during sample handling, and uncontrolled admixture of serum‐derived IgG and monomeric IgA. Despite such problems, saliva remains an interesting biological fluid with great scientific and clinical potentials.
Human amygdala activation during rapid eye movements of rapid eye movement sleep: an intracranial study

The amygdaloid complex plays a crucial role in processing emotional signals and in the formation of emotional memories. Neuroimaging studies have shown human amygdala activation during rapid eye movement sleep (REM). Stereotactically implanted electrodes for presurgical evaluation in epileptic patients provide a unique opportunity to directly record amygdala activity. The present study analysed amygdala activity associated with REM sleep eye movements on the millisecond scale. We propose that phasic activation associated with rapid eye movements may provide the amygdala with endogenous excitation during REM sleep. Standard polysomnography and stereo‐electroencephalograph (SEEG) were recorded simultaneously during spontaneous sleep in the left amygdala of four patients. Time–frequency analysis and absolute power of gamma activity were obtained for 250 ms time windows preceding and following eye movement onset in REM sleep, and in spontaneous waking eye movements in the dark. Absolute power of the 44–48 Hz band increased significantly during the 250 ms time window after REM sleep rapid eye movements onset, but not during waking eye movements. Transient activation of the amygdala provides physiological support for the proposed participation of the amygdala in emotional expression, in the emotional content of dreams and for the reactivation and consolidation of emotional memories during REM sleep, as well as for next‐day emotional regulation, and its possible role in the bidirectional interaction between REM sleep and such sleep disorders as nightmares, anxiety and post‐traumatic sleep disorder. These results provide unique, direct evidence of increased activation of the human amygdala time‐locked to REM sleep rapid eye movements.
Human Papilloma Virus 16 E6 RNA Interference Enhances Cisplatin and Death Receptor-Mediated Apoptosis in Human Cervical Carcinoma Cells

In cervical cancer, the p53 and retinoblastoma (pRb) tumor suppressor pathways are disrupted by the human papilloma virus (HPV) E6 and E7 oncoproteins, because E6 targets p53 and E7 targets pRb for rapid proteasome-mediated degradation. We have investigated whether E6 suppression with small interfering RNA (siRNA) restores p53 functionality and sensitizes the HPV16-positive cervical cancer cell line SiHa to apoptosis by cisplatin, irradiation, recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL), or agonistic anti-Fas antibody. E6 siRNA resulted in decreased E6 mRNA levels and enhanced p53 and p21 expression, demonstrating the restoration of p53 functionality in SiHa cells, without inducing high levels of apoptosis (<10%). Cell surface expression of the proapoptotic death receptors (DRs) DR4, DR5, and Fas was not affected by E6 suppression. E6 suppression conferred susceptibility to cisplatin-induced apoptosis but not to irradiation-, rhTRAIL-, or anti-Fas antibody-induced apoptosis. Combining cisplatin with rhTRAIL or anti-Fas antibody induced even higher apoptosis levels in E6-suppressed cells. At the molecular level, cisplatin treatment resulted in elevated p53 levels, enhanced caspase-3 activation, and reduced p21 levels in E6-suppressed cells. Cisplatin in combination with death receptor ligands enhanced caspase-8 and caspase-3 activation and reduced X-linked inhibitor-of-apoptosis protein (XIAP) levels in these cells. We showed using siRNA that the enhanced apoptosis in E6-supressed cells was related to reduced XIAP levels and not due to reduced p21 levels. In conclusion, targeting E6 or XIAP in combination with cisplatin can efficiently potentiate rhTRAIL-induced apoptosis in HPV-positive cervical cancer cells.
Akt Signaling Regulates Side Population Cell Phenotype via Bcrp1 Translocation*

Akt is an important regulator of cell survival, growth, and glucose metabolism in many cell types, but the role of this signaling molecule in hematopoietic stem cells is poorly defined. Side population (SP) cells are enriched for hematopoietic stem cell activity and are defined by their ability to efficiently efflux Hoechst 33342. Bone marrow from Akt1-null mice exhibited a reduced SP fraction. However, bone marrow cellularity, growth factor-responsive progenitor cultures, and engraftable stem cells were normal in these mice. Treatment of bone marrow with LY294002, an inhibitor of the Akt effector protein phosphatidylinositol 3-kinase, led to a reversible loss of the SP fraction. Bcrp1, which encodes the Hoechst dye transporter, was translocated from the membrane to the intracellular compartment under conditions that promote the SP-depleted state. Lentivirus-mediated overexpression of Akt1 in bone marrow markedly increased the SP fraction, whereas there was no effect on bone marrow from Bcrp-/- mice. These data suggest that Akt signaling modulates the SP cell phenotype by regulating the expression of Bcrp1.
Intrinsic and extrinsic determinants of ion channel localization in neurons

Neurons are an extremely diverse group of excitable cells with a wide variety of morphologies including complex dendritic trees and very long axons. The electrical properties of neurons depend not only on the types of ion channels and receptors expressed, but also on where these channels are located in the cell. Two extreme examples that illustrate the subcellular polarized nature of neurons and the tight regulation of ion channel localization can be seen at the axon initial segment and the node of Ranvier. The axon initial segment is important for initiation of action potentials in the axon, whereas the node of Ranvier is required for the rapid, faithful and efficient propagation of action potentials along the axon. Given the similarity of their functions it is not surprising that nearly every protein component of the axon initial segment is also found at the node. However, there is one very important difference between these two sites: nodes require extrinsic, glial‐derived factors in order to form, whereas the axon initial segment is intrinsically determined by the neuron. This mini‐review discusses recent results that have begun to clarify the intrinsic and extrinsic mechanisms underlying formation of nodes and axon initial segments, and poses several important unanswered questions regarding their unique mechanisms of formation.
Influence of degree of carotid artery stenosis and collateral pathways and effect of carotid endarterectomy on cerebral vasoreactivity.

OBJECTIVE The goal was to determine the influence of the degree of internal carotid artery (ICA) stenosis and collateral pathways on cerebral vasoreactivity (CVR). The effect of carotid endarterectomy on CVR is also presented. METHODS For 36 patients with unilateral ICA stenosis of at least 70%, regional cerebral blood flow (rCBF) and regional CVR (rCVR) were investigated before and after carotid endarterectomy, with resting and acetazolamide-challenge single photon emission computed tomographic scans. The degree of ICA stenosis and the status of the collateral pathways (sizes of the A1 segment and the posterior communicating artery) were evaluated by angiography. RESULTS Thirteen patients were classified as Type N/N (normal rCBF and normal rCVR), 5 as Type R/N (reduced rCBF and normal rCVR), 6 as Type N/R (normal rCBF and reduced rCVR), and 12 as Type R/R (reduced rCBF and reduced rCVR). The degree of ICA stenosis correlated with rCVR status. The size of the A1 segment was a second-rank factor and was less effective in affecting rCVR. The size of the posterior communicating artery was not associated with rCVR. The predictive value of reduced rCVR for postoperative improvement (100%) was significantly higher than that of reduced rCBF (50%). CONCLUSION The present results indicate that the degree of ICA stenosis is a more significant determinant of CVR than are the collateral pathways in patients with carotid artery stenosis. The high predictive rate of reduced rCVR for postoperative improvement implies that acetazolamide-challenge single photon emission computed tomographic scanning might be useful in selecting patients with asymptomatic ICA stenosis who might benefit from carotid endarterectomy.
Study on the Optimal Investment Timing of Visitor Attractions under the Uncertainty of Tourism Demand

the investment of visitor attractions (IVA) is irreversible and uncertain. Tourism demand is the main uncertain factor affected it. Based on the Real Options Theory, this paper studies the optimal investment timing of visitor attractions (VA) under the uncertainty of tourism demand, and does the numerical analysis to the parameters in the model. The conclusion is: the greater the uncertainty of tourism demand is the greater value of the project and the options are. So the investment company tends to wait rather than invest immediately.
The ability of different forms of heparins to suppress P-selectin function in vitro correlates to their inhibitory capacity on bloodborne metastasis in vivo

Summary Ample evidence suggests that many of the in vivo anti-metastatic effects by heparins reflect their actions on P-selectin-mediated binding. We hypothesized that the ability of widely used heparins and derivatives to interfere with P-selectin-dependent tumour cell interactions under flow in vitro could be used to identify anticoagulants with advanced inhibitory functions on experimental blood-borne metastasis in vivo. To test this assumption, the impact of unfractionated heparin, the low-molecular-weight heparins (LMWH) nadroparin and enoxaparin, and the synthetic pentasaccharide fondaparinux on P-selectin-dependent tumour interactions in vitro and metastasis formation in vivo were evaluated. Our data revealed that these commonly used anticoagulants widely differ in their potential to interfere with P-selectinmediated cell binding. Importantly, the superior inhibitory capacity on P-selectin function of unfractionated heparin and LMWH nadroparin as opposed to LMWH enoxaparin and synthetic heparin pentasaccharide fondaparinux strongly correlated to the inhibitory potency of each in inhibiting experimental lung metastasis in vivo. Hence, P-selectin inhibition may constitute a valuable feature to identify anticoagulants that are suitable for anticancer therapy.
Improvement Trajectories in Operations and Technology Management: Concept, Process and Content Issues

This study introduces a framework for the analysis of improvement trajectories in operations and technology management. In the first part, the concept of improvement trajectories in operations is defined, grounding on the evolutionary economic issues of path dependence and dynamic capabilities. In the second part, seven dimensions of the process and content of improvement trajectories are reviewed and integrated into a research framework, and research propositions are built to ground further research on the subject. In the third part, the roles of implementation history, innovation capabilities, and strategic orientation as determinants of improvement trajectory success are discussed.