Miracle-dz/UniFAR-FTUs huggingface dataset:
Linking rain into ice microphysics across the melting layer in stratiform rain: a closure study

Abstract. This study investigates the link between rain and ice microphysics across the melting layer in stratiform rain systems using measurements from vertically pointing multi-frequency Doppler radars. A novel methodology to examine the variability of the precipitation rate and the mass-weighted melted diameter (Dm) across the melting region is proposed and applied to a 6 h long case study, observed during the TRIPEx-pol field campaign at the Jülich Observatory for Cloud Evolution Core Facility and covering a gamut of ice microphysical processes. The methodology is based on an optimal estimation (OE) retrieval of particle size distributions (PSDs) and dynamics (turbulence and vertical motions) from observed multi-frequency radar Doppler spectra applied both above and below the melting layer. First, the retrieval is applied in the rain region; based on a one-to-one conversion of raindrops into snowflakes, the retrieved drop size distributions (DSDs) are propagated upward to provide the mass-flux-preserving PSDs of snow. These ice PSDs are used to simulate radar reflectivities above the melting layer for different snow models and they are evaluated for a consistency with the actual radar measurements. Second, the OE snow retrieval where Doppler spectra are simulated based on different snow models, which consistently compute fall speeds and electromagnetic properties, is performed. The results corresponding to the best-matching models are then used to estimate snow fluxes and Dm, which are directly compared to the corresponding rain quantities. For the case study, the total accumulation of rain (2.30 mm) and the melted equivalent accumulation of snow (1.93 mm) show a 19 % difference. The analysis suggests that the mass flux through the melting zone is well preserved except the periods of intense riming where the precipitation rates were higher in rain than in the ice above. This is potentially due to additional condensation within the melting zone in correspondence to high relative humidity and collision and coalescence with the cloud droplets whose occurrence is ubiquitous with riming. It is shown that the mean mass-weighted diameter of ice is strongly related to the characteristic size of the underlying rain except the period of extreme aggregation where breakup of melting snowflakes significantly reduces Dm. The proposed methodology can be applied to long-term observations to advance our knowledge of the processes occurring across the melting region; this can then be used to improve assumptions underpinning spaceborne radar precipitation retrievals.
Sex Dimorphism in Muscle Damage–induced Inflammation

ABSTRACT Introduction The purpose of this study was to determine the effect of resistance exercise (RE)–induced hormonal changes on intramuscular cytokine gene expression after muscle damage in untrained men and women. Methods Men (n = 8, 22 ± 3 yr) and women (n = 8, 19 ± 1 yr) completed two sessions of 80 unilateral maximal eccentric knee extensions followed by either an upper body RE bout (EX) or a time-matched period (CON). Muscle samples (vastus laterals) were analyzed for mRNA expression of interleukin (IL) 6, IL-10, IL-15, TNFA, TGFB, CCL2, and CD68 at PRE, 12 h, and 24 h after the session. Results A significant time–sex–condition interaction was found for TGFB with an increase for EX in men at 12 h from PRE. For EX, TGFB was also greater in men than in women at 12 and 24 h. Significant time–sex and condition–sex interactions were found for IL-10 with an increase for men that was greater than for women at 12 and 24 h. IL-10 was lower in EX than CON for men. A significant time–sex interaction was found for TNFA with an increase for men that was greater than for women at 24 h. A significant time–condition interaction was found for CD68 with an increase at 12 h and decrease at 24 h for EX and CON. CD68 was lower in EX than CON at 12 h. A significant time effect was found for IL6 and CCL2 with an increase at 12 and 24 h. Conclusions Results suggest that women seem to have a muted intramuscular cytokine (i.e., IL-10, TNF-α, and TGF-β) response to muscle damage compared with men.
Formaldehyde total column densities over Mexico City: comparison between multi-axis differential optical absorption spectroscopy and solar-absorption Fourier transform infrared measurements

Abstract. Formaldehyde (HCHO) total column densities over the Mexico City metropolitan area (MCMA) were retrieved using two independent measurement techniques: multi-axis differential optical absorption spectroscopy (MAX-DOAS) and Fourier transform infrared (FTIR) spectroscopy. For the MAX-DOAS measurements, the software QDOAS was used to calculate differential slant column densities (dSCDs) from the measured spectra and subsequently the Mexican MAX-DOAS fit (MMF) retrieval code to convert from dSCDs to vertical column densities (VCDs). The direct solar-absorption spectra measured with FTIR were analyzed using the PROFFIT (PROFile FIT) retrieval code. Typically the MAX-DOAS instrument reports higher VCDs than those measured with FTIR, in part due to differences found in the ground-level sensitivities as revealed from the retrieval diagnostics from both instruments, as the FTIR and the MAX-DOAS information do not refer exactly to the same altitudes of the atmosphere. Three MAX-DOAS datasets using measurements conducted towards the east, west or both sides of the measurement plane were evaluated with respect to the FTIR results. The retrieved MAX-DOAS HCHO VCDs where 6 % , 8 % and 28 % larger than the FTIR measurements which, supported with satellite data, indicates a large horizontal inhomogeneity in the HCHO abundances. The temporal change in the vertical distribution of this pollutant, guided by the evolution of the mixing-layer height, affects the comparison of the two retrievals with different sensitivities (total column averaging kernels). In addition to the reported seasonal and diurnal variability of HCHO columns within the urban site, background data from measurements at a high-altitude station, located only 60 km away, are presented.
Co-location of the downdip end of seismic locking and the continental shelf break

<p>Along subduction margins, the morphology of the near shore domain records the combined action of erosion from ocean waves and permanent tectonic deformation from the convergence of plates. We observe that at subduction margins around the globe, the edge of continental shelves tends to be located above the downdip end of seismic coupling on the megathrust (locking depth). Coastlines lie farther landward at variable distances. This observation stems from a compilation of well-resolved coseismic and interseismic<span>&#160; </span>coupling datasets. The permanent interseismic uplift component of the total tectonic deformation can explain the localization of the shelf break. It contributes a short wave-length gradient in vertical deformation on top of the structural and isostatic deformation of the margin. This places a hinge line between seaward subsidence and landward uplift above the locking depth. Landward of the hinge line, rocks are uplifted in the domain of wave-base erosion and a shelf is maintained by the competition of rock uplift and wave erosion. Wave erosion then sets the coastline back from the tectonically meaningful shelf break. We combine a wave erosion model with an elastic deformation model to show how the locking depth pins the location of the shelf break. In areas where the shelf is wide, onshore geodetic constraints on seismic coupling is limited and could be advantageously complemented by considering the location of the shelf break. Subduction margin morphology integrates hundreds of seismic cycles and could inform seismic coupling stability through time. </p>
Pro-Tumorigenic Macrophage Infiltration in Oral Squamous Cell Carcinoma and Possible Macrophage-Aimed Therapeutic Interventions

In Oral Squamous Cell Carcinomas (OSCC), as in other solid tumors, stromal cells strongly support the spread and growth of the tumor. Macrophages in tumors (tumor-associated macrophages or “TAMs”), can swing between a pro-inflammatory and anti-tumorigenic (M1-like TAMs) state or an anti‐inflammatory and pro-tumorigenic (M2-like TAMs) profile depending on the tumor microenvironment cues. Numerous clinical and preclinical studies have demonstrated the importance of macrophages in the prognosis of patients with different types of cancer. Here, our aim was to review the role of M2-like TAMs in the prognosis of patients with OSCC and provide a state of the art on strategies for depleting or reprogramming M2-like TAMs as a possible therapeutic solution for OSCC. The Clinical studies reviewed showed that higher density of CD163+ M2-like TAMs associated with worse survival and that CD206+ M2-TAMs are involved in OSCC progression through epidermal growth factor (EGF) secretion, underlining the important role of CD206 as a marker of OSCC progression and as a therapeutic target. Here, we provide the reader with the current tools, in preclinical and clinical stage, for depleting M2-like TAMs, re-educating them towards M1-like TAMs, and exploiting TAMs as drug delivery vectors.
Optimising a Simple Fully Convolutional Network for Accurate Brain Age Prediction in the PAC 2019 Challenge

Brain age prediction from brain MRI scans not only helps improve brain ageing modelling generally, but also provides benchmarks for predictive analysis methods. Brain-age delta, which is the difference between a subject’s predicted age and true age, has become a meaningful biomarker for the health of the brain. Here, we report the details of our brain age prediction models and results in the Predictive Analysis Challenge 2019. The aim of the challenge was to use T1-weighted brain MRIs to predict a subject’s age in multicentre datasets. We apply a lightweight deep convolutional neural network architecture, Simple Fully Convolutional Neural Network (SFCN), and combined several techniques including data augmentation, transfer learning, model ensemble, and bias correction for brain age prediction. The model achieved first places in both of the two objectives in the PAC 2019 brain age prediction challenge: Mean absolute error (MAE) = 2.90 years without bias removal, and MAE = 2.95 years with bias removal.
Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio

To meet the anabolic demands of the proliferative potential of tumor cells, malignant cells tend to rewire their metabolic pathways. Although different types of malignant cells share this phenomenon, there is a large intracellular variability how these metabolic patterns are altered. Fortunately, differences in metabolic patterns between normal tissue and malignant cells can be exploited to increase the therapeutic ratio. Modulation of cellular metabolism to improve treatment outcome is an emerging field proposing a variety of promising strategies in primary tumor and metastatic lesion treatment. These strategies, capable of either sensitizing or protecting tissues, target either tumor or normal tissue and are often focused on modulating of tissue oxygenation, hypoxia-inducible factor (HIF) stabilization, glucose metabolism, mitochondrial function and the redox balance. Several compounds or therapies are still in under (pre-)clinical development, while others are already used in clinical practice. Here, we describe different strategies from bench to bedside to optimize the therapeutic ratio through modulation of the cellular metabolism. This review gives an overview of the current state on development and the mechanism of action of modulators affecting cellular metabolism with the aim to improve the radiotherapy response on tumors or to protect the normal tissue and therefore contribute to an improved therapeutic ratio.
Reproductive Isolation Between Taxonomically Controversial Forms of the Gray Voles (Microtus, Rodentia; Arvicolinae): Cytological Mechanisms and Taxonomical Implications

The formation of hybrid sterility is an important stage of speciation. The voles of the genus Microtus, which is the most speciose genus of rodents, provide a good model for studying the cytological mechanisms of hybrid sterility. The voles of the “mystacinus” group of the subgenus Microtus (2n = 54) comprising several recently diverged forms with unclear taxonomic status are especially interesting. To resolve the taxonomic status of Microtus mystacinus and Microtus kermanensis, we crossed both with Microtus rossiaemeridionalis, and M. kermanensis alone with Microtus arvalis “obscurus” and M. transcaspicus and examined the reproductive performance of their F1 hybrids. All interspecies male hybrids were sterile. Female M. kermanensis × M. arvalis and M. kermanensis × M. transcaspicus hybrids were sterile as well. Therefore, M. mystacinus, M. kermanensis, and M. rossiaemeridionalis could be considered valid species. To gain an insight into the cytological mechanisms of male hybrid sterility, we carried out a histological analysis of spermatogenesis and a cytological analysis of chromosome synapsis, recombination, and epigenetic chromatin modifications in the germ cells of the hybrids using immunolocalization of key meiotic proteins. The hybrids showed wide variation in the onset of spermatogenesis arrest stage, from mature (although abnormal) spermatozoa to spermatogonia only. Chromosome asynapsis was apparently the main cause of meiotic arrest. The degree of asynapsis varied widely across cells, individuals, and the crosses—from partial asynapsis of several small bivalents to complete asynapsis of all chromosomes. The asynapsis was accompanied by a delayed repair of DNA double-strand breaks marked by RAD51 antibodies and silencing of unpaired chromatin marked by γH2A. X antibodies. Overall, the severity of disturbances in spermatogenesis in general and in chromosome synapsis in particular increased in the hybrids with an increase in the phylogenetic distance between their parental species.
Phylogenetic Patterns in Mouth Posture and Echolocation Emission Behavior of Phyllostomid Bats

While phyllostomid bats show an impressive range of feeding habits, most of them emit highly similar echolocation calls. Due to the presence of an often prominent noseleaf, it has long been assumed that all phyllostomids emit echolocation calls exclusively through the nostrils rather than through the mouth. However, photo evidence documents also phyllostomid bats flying with an opened mouth. We hypothesized that all phyllostomid species emit echolocation calls only through the nostrils and therefore fly consistently with a closed mouth, and that observations of an open mouth should be a rare and random behavior among individuals and species. Using a high-speed camera and standardized conditions in a flight cage, we screened 40 phyllostomid species. Behavior varied distinctly among the species and mouth posture shows a significant phylogenetic signal. Bats of the frugivorous subfamilies Rhinophyllinae and Carolliinae, the nectarivorous subfamilies Glossophaginae and Lonchophyllinae, and the sanguivorous subfamily Desmodontinae all flew consistently with open mouths. So did the animalivorous subfamilies Glyphonycterinae, Micronycterinae and Phyllostominae, with the notable exception of species in the omnivorous genus Phyllostomus, which consistently flew with mouths closed. Bats from the frugivorous subfamily Stenodermatinae also flew exclusively with closed mouths with the single exception of the genus Sturnira, which is the sister clade to all other stenodermatine species. Further, head position angles differed significantly between bats echolocating with their mouth closed and those echolocating with their mouths opened, with closed-mouth phyllostomids pointing only the nostrils in the direction of flight and open-mouth phyllostomids pointing both the nostrils and mouth gape in the direction of flight. Ancestral trait reconstruction showed that the open mouth mode is the ancestral state within the Phyllostomidae. Based on the observed behavioral differences, we suggest that phyllostomid bats are not all nasal emitters as previously thought and discuss possible reasons. Further experiments, such as selectively obstructing sound emission through nostrils or mouth, respectively, will be necessary to clarify the actual source, plasticity and ecological relevance of sound emission of phyllostomid bats flying with their mouths open.
Factors Affecting Gut Microbiome in Daily Diet

There is a growing recognition that a good diet can help people maintain mental and physical health, while a bad one will cause the disorder of body function, and even lead to several diseases. A lot of attentions have been devoted to analyze every possible health-related factor in the daily diet, including food ingredients, additives, and cooking process. With the support of high-throughput sequencing technology, there is accumulating evidence gradually clarifying that most of these factors are mainly through the interactions with gut microbiome to trigger downstream effects. The gut microbiome may be able to act as a very sensitive mirror in response to human daily diet. A complex network of interactions among diet, gut microbiome, and health has been gradually depicted, but it is rarely discussed from a more comprehensive perspective. To this end, this review summarized the latest updates in diet-gut microbiome interactions, analyzed most identified factors involved in this process, showed the possibility of maintaining health or alleviating diseases by diet intervention, aiming to help people choose a suitable recipe more accurately.
Therapeutic Potential of HUMSCs in Female Reproductive Aging

With the development of regenerative medicine, stem cells are being considered more frequently for the treatment of reproductive aging. Human umbilical cord mesenchymal stem cells have been reported to improve the reserve function of aging ovaries through their homing and paracrine effects. In this process, paracrine factors secreted by stem cells play an important role in ovarian recovery. Although the transplantation of human umbilical cord mesenchymal stem cells to improve ovarian function has been studied with great success in animal models of reproductive aging, their application in clinical research and therapy is still relatively rare. Therefore, this paper reviews the role of human umbilical cord mesenchymal stem cells in the treatment of reproductive aging and their related mechanisms, and it does so in order to provide a theoretical basis for further research and clinical treatment.
The Patients' Practises Disclosing Subjective Experiences in the Psychiatric Intake Interview

In psychiatric diagnostic interviews, a clinician's question designed to elicit a specific symptom description is sometimes met with the patient's self-disclosure of their subjective experience. In shifting the topical focus to their subjective experiences, the patients do something more or something other than just answering the question. Using conversation analysis, we examined such sequences in diagnostic interviews in an outpatient clinic in Finland. From 10 audio-recorded diagnostic interviews, we found 45 segments where medical questions were met with patients' self-disclosures. We show four sequential trajectories that enable this shift of topic and action. There are four possible trajectories: (1) the patient first answers the medical question and the clinician acknowledges this answer, whereupon the patient shifts to a self-disclosure of their subjective experience; (2) the patient first gives the medical answer but shifts to self-disclosure without the clinician's acknowledgement of that answer; (3) the patient produces an extensive answer to the medical question and, in the course of producing this, shifts into the self-disclosure; (4) the patient does not offer a medical answer but designs the self-disclosure as if it were the answer to the medical question. We argue that in the shifts to the self-disclosure of their subjective negative experience, the patients take local control of the interaction. These shifts also embody a clash between the interactional projects of the participants. At the end of the paper, we discuss the clinical relevance of our results regarding the patient's agency and the goals of the psychiatric assessment.
Earthworms of the World

For decades, scientists have known where the highest numbers of species that live aboveground are found. So, they made maps of the world showing these patterns. For most of the aboveground groups, the highest numbers of species occur in the tropics and numbers decrease toward the poles. However, until recently, we did not understand such global patterns for many organisms living in the soil. We decided to create global maps of earthworm species richness. Earthworms provide humans with many useful services, such as moving the soils and improving their quality, which can increase the amount of food that is grown. If we want to protect earthworms and the services they provide, these global maps of earthworms are important because we need to understand where they are and why they live there.
Perceived Impact of Social Media on Panic Buying: An Online Cross-Sectional Survey in Iraqi Kurdistan

Background: Social media has an impact on panic buying by creating fear, disseminating pictures, and videos of people purchasing extra goods in a state of panic during the COVID-19 pandemic. Aim: We aimed to evaluate the perceived impact of social media on panic buying behaviors in the Iraqi Kurdistan region. Methods: This cross-sectional survey was conducted from October 10 to November 25, 2020. A self-reported instrument was designed in English and then translated to the Kurdish Language to conduct the study. It was disseminated through social media platforms (Facebook, Viber, and WhatsApp) and e-mail, via a link, and 466 responses were collected from social media users. The statistical computations were performed using SPSS version 21. Results: The majority of respondents were male (62.2%), were <25 years old (43.9%), and had completed their bachelor's degree (53.9%), and most of the respondents (86.3%) used Facebook. Among the respondents, 42.1% were involved in panic buying, 32.8% of the respondents thought that social media platforms had an influence on panic buying, 86.1% of the respondents thought that social media should be sensible while reporting it, 88.4% thought that the reporting should be controlled, and 78.5% thought that photos of empty shelves should be avoided. There was a significant positive statistical correlation (r = 0.84) between social media use and panic buying among consumers during the COVID-19 pandemic in Iraqi Kurdistan (p = <0.001). Conclusion: This research assessed how social media affects buying behavior, particularly in Iraq. Collective measures, such as sensible use and adequate media literacy, are needed to prevent such behaviors at least during public health emergencies.