Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding student nurse learning: a comparative study of learning through nurse education programmes for the Republic of Ireland and Northern Ireland

There is an increasing emphasis on accountability in all public services, which in nursing is based on the desired political objective of aligning nursing more closely with the goals of health services. This study fundamentally is derived from the increasing demand for economic models of nurse education as a process within a wider economic agenda which converts inputs (example training costs) into outputs (example registered nurses). This thesis provides an understanding of student nurse learning as it occurs through nurse education programmes for the Republic of Ireland and Northern Ireland. A research design of triangulation including quantitative and qualitative measures was utilised to provide a greater breadth and depth of understanding on contrasting philosophies, objectives and practices arising trom the two different models of nurse education. The cohort included all student nurses (1122) who commenced a nurse education and training programme m October 1991 m the Republic ot Ireland (714 nurse student nurses) and Northern Ireland (408 students nurses). The findings demonstrate significant differences in regard to learning between student nurses from Northern Ireland and between student nurses from general, psychiatric, mental handicap and sick childrens, m the Republic of Ireland and between younger and older student nurses. The study does however, identify a number of key factors which emerged from all measurements and transcended all programmes and therefore appear to be fundamental to student nurse learning. These are presented as a twelve factor heuristic model of student nurse learning. The central tenet of the study is that student nurse learning is context dependent Students’ constructs of learning are dependent on their interpretation of the demands of the task, influenced by the assessment and teaching, their previous knowledge, experience and personal characteristics. It is concluded that the profession of nursing must be deliberate m pursuing quality learning in nurse education and must be determined in its explicit procurement of the type of education desirable for the futuie practice of nursing.
Anticipative model predictive control for linear parameter-varying systems

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Abstract 3671: Dietary-induced Obesity in Mice results in Metabolic and Vascular Insulin-like Growth Factor 1 Resistance

Endothelial cell dysfunction, characterised by a reduction in the bioavailability of nitric oxide (NO), plays an important role in the initiation of atherosclerosis. IGF-1 may be involved in the regulation of NO production via the Phosphoinositide 3-kinase (PI3-K)/Akt/eNOS pathway. In this study we have investigated whether dietary-induced obesity leads to disturbances of this pathway. C57/Blk6 mice fed a high fat diet for 20weeks (n=12) showed a significant increase in body weight and fat pad size when compared to chow fed controls (n=12). Blood pressure measurement showed an age-related increase in systolic blood pressure in high fat fed (19.2% from baseline) versus chow fed mice (7.6% from baseline). Blood glucose levels increased from 13.5 to 20mmol/l at 120mins in high fat fed mice, versus 5.7 to 7.3mmol/l in the chow fed group (p=0.009) by tolerance testing. In response to insulin, blood glucose fell by 72% in the chow fed group versus 48% in the high fat fed group (p= 0.0002). The high fat fed mice were less sensitive to IGF-1 stimulation than the chow fat mice by IGF-1 tolerance testing (p=0.046 at 30mins). The basal protein level of phosphorylated eNOS in the aortae of the high fat fed mice was 24.2% less than that of the chow fed mice. Upon IGF-1 stimulation levels of phosphorylated eNOS increased by 45.1% in the chow fed mice compared to a slight decrease of 5% in the high fat fed mice after normalisation to eNOS protein levels. eNOS activity in the aortae of chow fed mice, measured by an ex-vivo L-citrulline assay, showed an increase of 1.6-fold in response to IGF-1 (100 nM; 10 minutes) when compared to the high fat fed mice (n=5; p
Livability Assessment of Low-Income Flats in Dandangan, Kediri City

Rapid urbanization and land scarcity in Indonesia’s urban areas have caused the demand for housing need of the low-income population to be more arduous to obtain. Regarding slum issues and the urgency of livable and low-cost housing, the government makes an effort to develop affordable rental flats for low income which is termed as Rusunawa. The use of Post Occupancy Evaluation (POE), focuses on the evaluation of the buildings. It is considered the rental flats as a physical building and not as a ‘home’ where the living area of the occupants should be a convenient place to live, which includes their social psychology aspect. Dandangan. This research aims to assess the livability of Dandangan Flats a rental flat in Kediri City that provides a comfortable home for low-income inhabitants and industrial workers as well as handling the slums. Determination of livable flat criteria uses expert judgment and assessment livability of Dandangan flats with service quality method. The result revealed that livability of rental flats has 44 criteria, which are divided into six aspects, i.e., physical dwelling, security and safety, accessibility to public facilities, amenities, social interactions and economical. The results of livability assessment in Dandangan Flat according to the gap score belong to medium category. Ex-slum dwellers (block A&B) have a better perception of Dandangan flats in the livability assessment. The most important aspects of livability are safety and security.
Comparative safety of H1 antihistamines.

In the allergic reaction, mast cells degranulate, releasing inflammatory mediators including histamine. The H1 receptor antihistamines have been developed over the past 50 years to minimize the clinical symptoms caused by this reaction. Currently, H1 antihistamines are taken by approximately 30 million Americans per year. First-generation H1 antihistamines, some of which are available without prescription, can cross the blood-brain barrier and have been reported to produce sedation in 10% to 25% of users. When activities that require mental alertness and concentration are considered--school performance and driving, for example--this effect is troublesome and even potentially hazardous. The newer, second-generation H1 antihistamines (eg, astemizole, cetirizine, loratadine, terfenadine) have difficulty entering the brain because they are typically large, lipophobic molecules that have charged side chains and are extensively bound to protein. Consequently, they appear to induce sedation less commonly than classic antihistamines. Since a primary tenet of medical care has always been primum non nocere--first of all, in the management of clinical illness, do no harm--it is important in these "State-of-the-Art Perspectives" to address the comparative safety of the H1 antihistamines. A number of methodologies have been used to make this assessment, including the multiple sleep latency test, the P300 (P3) wave of the auditory-evoked potential, self-ratings, visual function tests, and tests that measure reaction times, visual-motor coordination, and driving skills. The effect of the interaction of H1 antihistamines with alcohol and tranquilizers also has been examined. (ABSTRACT TRUNCATED AT 250 WORDS)
Leucomalacia periventricular e hiperecogenicidad persistente: Relación entre hallazgos ecográficos y secuelas

Objetivo: conocer la incidencia de la leucomalacia periventricular e hipercogenicidad persistente en recien nacidos con peso menor de 1500 gramos y la relacion entre los hallazgos ecograficos y la evolucion a los 18 meses de edad corregida. Conclusiones: la leucomalacia periventricular multiplica el riesgo de secuelas por 15. La hiperecogenicidad persistente (independientemente de su grado), no aumenta significativamente el riesgo de secuelas. Sin embargo, el presentar una hiperecogenicidad persistente moderada multiplica el riesgo de secuelas por 9.
The introduction of referral orders into the youth justice system: Second interim report. Funded/commissioned by: RDS Occasional Paper No. 73

The referral order The Youth Justice and Criminal Evidence Act 1999 introduces a new primary sentencing disposal – the referral order – for 10-17 year olds pleading guilty and convicted for the first time by the courts. The disposal involves referring the young offender to a youth offender panel (YOP). The work of YOPs is to be governed by the principles ‘underlying the concept of restorative justice’: defined as ‘restoration, reintegration and responsibility’ (Home Office, 1997: 31-2). The pilots Referral orders are currently being piloted in eleven areas: Blackburn with Darwen, Cardiff, Nottingham, Nottinghamshire, Oxfordshire, Swindon, Suffolk, Wiltshire, Hammersmith and Fulham, Kensington and Chelsea, and Westminster. The introduction of referral orders was staggered across the pilot areas over the summer 2000. National roll-out of referral orders will begin on 1 April 2002. The pilots are being overseen by an inter-agency Referral Order Steering Group chaired by the Youth Justice Board and incorporating representation from the Home Office, Youth Justice Board, Lord Chancellor’s Department, Department of Education and Employment, Judicial Studies Board, evaluation team, police, youth offending teams (YOTs), Victim Support, NACRO and the Restorative Justice Consortium. This report This report concentrates on the first nine months of operation of referral orders. In particular it presents data on the operation of YOPs, and of the experience and views of some of the key actors in this new development in youth justice: offenders, YOT staff and Community Panel Members (CPMs). Published as Home Office Research and Development Statistics Division Occasional Paper No. 73
Trastorno agudo del lenguaje en ancianos: ¿origen isquémico o epileptico?

: Acute language disorder is highly suggestive of cerebrovascular disease, but when accompanied by behavioral disturbance, particularly in elderly patients, it may express a different etiology. Six women aged 71 to 84 years presented with a mild behavioral disturbance followed by a language disorder that included fluent dysphasia, paraphasia, dysnomia, perseveration, and impaired understanding of complex orders. They fully recovered within 24 h. MR-imaging, including diffusion-weighted sequences in five of them, showed no acute lesions. EEG showed epileptogenic waveforms in three cases and slow waves in the other three, in a location that included the left temporal region. These findings disappeared in subsequent controls. All of these tests were performed during the acute episode or up to 72 h after onset. No patient has presented a new episode so far. The high sensitivity of new neuroimaging techniques forces the search for non-vascular etiologies in those patients in which no structural lesions that could account for the symptoms can be demonstrated. EEG can be useful in the diagnosis of some of these stroke mimics. Acute language disorders accompanied by disturbed behavior in the elderly may reflect a partial seizure of the temporal lobe.
Feature Matching Based on Target Detection Optimization in Dynamic Scene

To improve the accuracy of ORB_SLAM2 pose estimation in dynamic environment, our paper proposes an effective method which uses the target detection algorithm to select the ROI of the key frame of the image, and then performs feature point matching. This method can be divided into three steps. Firstly, targets are detected and the ORB feature points are extracted from the input image, the corresponding pixel position coordinates of the object are eventually obtained in the scene; Secondly, feature point matching are performed on these ROI regions; Thirdly, the feature points with the relatively stable regions of interest are used to perform pose estimation. To verify the effectiveness of our method, the proposed method is tested on the public dataset. The experimental results show that the improved method can not only shorten the matching time, but also greatly improve the accuracy when compared with the traditional method. Thus, the original ORB_SLAM2 system can significantly improve the accuracy of pose estimation in dynamic environment.
Development of a translational animal model of sepsis

ii Co-Authorship Statement . iii Table of Contents . vi List of Tables . ix List of Figures . x List of Appendices . xiii List of Abbreviations . xiv Chapter 1 . 1 Introduction and Background . 1 1.1 Thesis Outline . 1 1.2 Sepsis . 2 1.3 The Microcirculation in Sepsis . 3 1.3.1 Microcirculatory Monitoring in the ICU . 5 1.4 Overview of Clinical Sepsis Diagnostic Criteria . 7 1.5 Early Goal-Directed Therapy in Sepsis . 9 1.5. 1 Resuscitation Fluids . 9 1.6 Animal Models of Sepsis . 13 1.6. 1 Design Constraints for a New Sepsis Model . 18 1.7 Objectives and Hypotheses . 19 1.8 References . 21 Chapter 2 . 25 Developing a translational animal model of sepsis . 25 2.1 Introduction . 25 2.2 Materials and Methods . 29 vii 2.2.1 Animal Instrumentation . 29 2.2.2 Dual Wavelength Intra-Vital Video Microscopy . 30 2.3 Experimental Protocol . 31 2.3.1 Video Recordings . 31 2.3.2 Blood Samples . 31 2.3.3 Video Processing and Functional Images . 32 2.3.4 Functional Capillary Density Measurement . 33 2.3.5 Physiological Data Analysis . 33 2.3.6 Physiological Variables . 34 2.3.7 Statistical Analysis . 34 2.4 Results . 34 2.4.1 Animals . 34 2.5 Discussion . 39 2.6 Conclusion . 43 2.7 References . 44 Chapter 3 . 46 Assessing fluid resuscitation efficacy in a translational animal model of sepsis . 46 3.1 Introduction . 46 3.2 Methods. 48 3.2.1 Feces Induced Peritonitis (FIP) . 49 3.2.2 Animal Instrumentation . 49 3.2.3 Dual Wavelength Intra-Vital Video Microscopy . 50 3.2.4 Clinical Hemodynamic Optimization Target . 50 3.3 Experimental Protocol . 50 3.3.1 Video Recordings . 50 3.3.2 Blood Samples . 51 viii 3.3.3 Capillary Analysis . 51 3.3.4 Functional Capillary Density Measurement . 51 3.3.5 Physiological Data Analysis . 52 3.3.6 Statistical Analysis . 52 3.4 Results . 53 3.5 Discussion . 61 3.6 Conclusion . 63 3.7 References . 65 Chapter 4 . 67 Contributions, Limitations and Future Directions . 67 4.1 Contributions . 67 4.2 Limitations/Additions . 69 4.3 Future Work . 71 4.4 References . 74 Appendix A: Animal Ethics Approval . 75 Appendix B: Camera Set-Up, Flow-Probe Measurement . 76 Dual-wavelength intra-vital video microscopy . 76 Transonic Flow Probe Cardiac Output Monitor . 80 References . 83 Appendix C: Protocol Modifications . 84 Modification 1 – Non Fluid-Resuscitated CLP . 84 Modification 2 – Resuscitated FIP Model . 86 Final Model – Translational FIP Model of Sepsis . 88 Appendix D: Curriculum Vitae . 89
An Examination of Title IX and its Impact on NCAA Male and Female Sports

In 2012, 40 years after Title IX of the Education Amendment Act was passed, women represented 8.73 teams per intercollegiate athletic department and totaled more than 200,000 female studentathletes in colleges and universities across the United States (Acosta & Carpenter, 2012). Since that time in 2012, Acosta and Carpenter (2014) conducted an update to the statistics of female employment and participation in intercollegiate athletics. In 2014, it was found that 13,963 female professionals are employed within intercollegiate athletics which indicates the highest number ever and is an increase of 171 since 2012 (Acosta & Carpenter, 2014) Participation opportunities for females are also at an all-time high with 9,581 women’s intercollegiate teams found at NCAA schools in 2014, increase of 307 since 2012. Furthermore, 8.83 women’s teams per school are the average offered to female athletics (Acosta & Carpenter, 2014).
Educación ambiental y desarrollo sustentable

La problematica actual respecto a la contaminacion ambiental, al cambio climatico y la degradacion de la naturaleza ha provocado un aumento en la preocupacion de muchos ciudadanos por las posibles consecuencias del tratamiento nocivo que el ser humano le esta dando a la naturaleza. Es un asunto de actualidad que debe ser explicado y que debe llegar a toda la poblacion de manera tal que supere el alcance de sun simple intercambio de informacion y se convierta en un proceso generador de conciencia etica fundamentada en el pensamiento critico que cuestione los actuales modelos de desarrollo que son responsables del deterioro ecologico y social.
Protein in der klinischen Ernährung kritisch kranker Patienten

Mit der Einführung der indirekten Kalorimetrie in die klinische Medizin durch Kinney et al. begann in den 1960er-Jahren die wissenschaftliche Erforschung des Stoffwechsels bei schweren überwiegend chirurgischen Erkrankungen, da es jetzt erstmals möglich war, den aktuellen Energieumsatz des Patienten zu bestimmen [3]. Seine Arbeiten haben damals gezeigt, dass multiple Frakturen mit einer Erhöhung von 30%, eine Sepsis mit einer Steigerung von 50% und schwere Verbrennungen sogar mit einer Verdoppelung des normalen Ruheenergieumsatzes einhergehen können [3].
Development and evaluation of biomarkers in Huntington’s Disease: furthering our understanding of the disease and preparing for clinical trials

Huntington’s Disease (HD) is a devastating hereditary neurodegenerative disease for which there are currently only symptomatic treatments. Several potentially curative pharmaceutical and genetic therapies are however in varying stages of development and therefore an increasing number of large-scale clinical trials of disease-modifying therapies are imminent. There is consequently a need for biomarkers which are sensitive to beneficial attenuation of disease-related changes. Functional, neuroimaging and biochemical biomarkers have been developed in HD (Andre et al. 2014;Weir et al. 2011). Neuroimaging biomarkers are strong candidates based on their clear relevance to the neuropathology of disease, proven precision and superior sensitivity compared with some standard functional measures (Tabrizi et al. 2011;Tabrizi et al. 2012). Their use in early-stage clinical trials, as surrogate end-points providing initial evidence of biological effect, is becoming increasingly common. Comparison of biomarkers in HD will help to clarify which measures, over varying time intervals, are most sensitive to disease progression. Additionally, the identification of robust fully-automated methods, comparable to manual and semi-automated gold-standards, would facilitate large-scale volumetric analysis. These methods however require validation in observational studies of neurodegenerative disease before they can be applied to sensitive clinical trial data. This thesis will develop and evaluate biomarkers for use in HD; both furthering our understanding of the disease and in preparation for use as end-points in clinical trials. A direct comparison of the sensitivity of diffusion and volumetric imaging biomarkers to HD-related change will be reported for the first time. Several exploratory imaging investigations are also described which enhance current knowledge of the relationship between neuroimaging metrics, brain functioning and behaviour, additionally strengthening the argument for the clinical relevance of neuroimaging measures as surrogate end-points in HD. The thesis will conclude with a comprehensive biomarker evaluation in early-stage HD, along with suggested strategies for selection of primary and secondary trial end-points based on effect sizes and corresponding sample size requirements.
Pengaruh Paparan Asap Rokok Terhadap Koklea Tikus Putih (Rattus norvegicus) Jantan Galur Sprague dawley

Rokok dapat menyebabkan berbagai macam kerusakan organ termasuk koklea sebagai organ pendengaran. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh paparan asap rokok terhadap kerusakan koklea tikus putih (Rattus norvegicus) jantan galur Sprague dawley secara histopatologis. Penelitian ini merupakan penelitian eksperimental laboratorik dengan desain pos ttest only control group design dengan menggunakan 18 ekor tikus putih galur Sprague dawley yang dibagi ke dalam 2 kelompok dan diberi perlakuan selama 14 hari. K1 diberi makan minum biasa, K2 dipapar asap rokok 3 batang/hari selama 14 hari, Hasil kerusakan koklea pada terdapat kerusakan sebanyak K1: 27%; K2: 80%; setiap 9 preparat mikroskopis Data diuji dengan Uji Kolmogorov-Smirnov, didapatkan p=0,037 (p<α) sehingga dapat disimpulkan bahwa terdapat pengaruh paparan asap rokok terhadap koklea tikus putih (Rattus norvegicus) jantan galur Sprague dawley secara histopatologis. Kata kunci: histopatologi, koklea, rokok
Max-MIG: an Information Theoretic Approach for Joint Learning from Crowds

Eliciting labels from crowds is a potential way to obtain large labeled data. Despite a variety of methods developed for learning from crowds, a key challenge remains unsolved: \emph{learning from crowds without knowing the information structure among the crowds a priori, when some people of the crowds make highly correlated mistakes and some of them label effortlessly (e.g. randomly)}. We propose an information theoretic approach, Max-MIG, for joint learning from crowds, with a common assumption: the crowdsourced labels and the data are independent conditioning on the ground truth. Max-MIG simultaneously aggregates the crowdsourced labels and learns an accurate data classifier. Furthermore, we devise an accurate data-crowds forecaster that employs both the data and the crowdsourced labels to forecast the ground truth. To the best of our knowledge, this is the first algorithm that solves the aforementioned challenge of learning from crowds. In addition to the theoretical validation, we also empirically show that our algorithm achieves the new state-of-the-art results in most settings, including the real-world data, and is the first algorithm that is robust to various information structures. Codes are available at \hyperlink{this https URL}{this https URL}
Physiology of ADH secretion.

: The past decade has witnessed continuing advances in our understanding of the physiology of vasopressin secretion. Despite some empirical and theoretical objections, linear regression analysis of the relationship between plasma vasopressin and plasma osmolality or sodium continues to provide a simple and useful way to describe the major functional properties of the osmoregulatory system. Recent studies employing this approach have shown that the sensitivity and "set" of the system can be altered independently, indicating that they have different bases and control mechanisms. All factors known to alter the sensitivity of the system also produce a reciprocal change in sensitivity to the antidiuretic action of vasopressin. This association suggests that the existence of some as yet unrecognized feedback signal that links the regulation of vasopressin secretion and action. The "set" of the osmoregulatory system appears subject to modification by a large number of physiologic and pathological variables, some of which may act directly or indirectly by endogenous opioids. Even the solute specificity of the osmoreceptor is subject to change since insulin deficiency significantly increases the stimulatory potency of hyperglycemia. A fuller understanding of the variables and mechanisms that alter the various properties of the osmoregulatory system will enhance management of clinical disorders of water balance and other diseases in which abnormalities in vasopressin secretion may play a role.