Miracle-dz/UniFAR-FTUs huggingface dataset:
NIMG-59PREDICTING THE RESPONSE TO TREATMENT IN GBM: MACHINE LEARNING ON CLINICAL IMAGES.

Patients suffering from glioblastoma exhibit a wide response to therapy. Studies relying on genetic/phenotypic markers to predict treatment response struggle to deliver clinically useful information in an actionable timeframe which underscores the need for a predictive measure produced by pre-treatment clinical information. Our group has previously described the Days Gained (DG) metric of response which is capable of stratifying patients by overall and progression free survival (Neal 2013). We sought to explore whether a predictive algorithm could be used to predict patients' response to therapy as measured by the DG metric. We studied 52 patients with newly diagnosed glioblastoma who had at least 2 pre-treatment and 1 post radiation therapy MRIs. The group was divided into a training (n = 31) and a test set (n = 21). A decision tree calculated through multiple iterations of linear regressions was used to generate variables that were correlated with the DG score and cluster the training patients according to clinically available variables. A random forest algorithm was used to search for the optimal model that would differentiate those patients who had a significant response to treatment (DG > 73), previously shown to be predictive of better overall survival (Neal 2013). The variables that clustered patients by treatment response were age, gender, Karnofsky Performance Score, tumors size on MRI (T1Gd and T2) at diagnosis, extent of resection, pre-treatment velocity, and the ratio of the net rates of diffusion to proliferation. A test performed on the test cohort showed 95% accuracy in predicting their response to treatment. This tool, utilizing nothing more than information available at the time of surgery, patients can be stratified according to expected response to adjuvant therapy. By targeting those patients that are predicted not to respond, clinicians can begin to consider more aggressive radiation schemes, faster implementation of salvage therapy or clinical trials.
Contingencies of Self-Worth and Global Self-Esteem Among College Women: The Role of Masculine and Feminine Traits Endorsement

The study examined the relative importance of seven contingencies of self-worth of Polish college women's (appearance, others' approval, competition, academic competencies, family support, virtue, God's love), as well as the associations between preference for particular contingencies and global self-esteem. Additionally, the predictive role of the self-assignment of masculine and feminine traits for both contingencies of self-worth and global self-esteem was investigated. The participants were one hundred and ninety-four Polish women in emerging adulthood (aged from 19 to 26; M = 21.36; SD = 1.67). Participants provided self-reports of self-ascription of masculine and feminine traits, the contingencies of self-worth, and self-esteem. Obtained results showed that the family support contingency of self-worth was the most preferred one, followed by virtue contingent self-worth, academic competencies, competition, and appearance contingencies of self-esteem, while the less preferred contingencies were: others' approval and God's love. Appearance and others’ approval contingencies of self-worth correlated negatively with self-esteem. Masculine traits were positively linked to competition contingency of self-worth, but negatively to physical appearance self-worth contingency and others’ approval self-worth contingency, whereas feminine traits were positively correlated with both physical appearance self-worth contingency and others’ approval self-worth contingency. The findings showed the positive associations between self-ascription of traits regarded to be masculine and self-esteem, and a lack of significant associations between self-description of feminine traits and self-esteem. Structural equation modeling demonstrated predictive role of masculine traits for self-esteem when feminine traits’ self-ascription and contingencies of self-worth were controlled.
Problem solving styles of the recruits of industrial trainer in Taiwan, Republic of China

In this study, the relationships between industrial trainers’ problem solving styles and their related variables were investigated. The sample consisted of 423 industrial trainers who majored in mechanical, electronic, and industrial technology programs at universities in Taiwan during the spring semester of 1997. The problem solving inventory was modified to form the research instrument for this study. The scale was divided into three subscales: (a) problem solving confidence (PSC); (b) approach/avoidance style (AA); and (c) personal control (PC). The total score of the problem solving scale was obtained by combining the scores of the three subscales. A lower total score represents greater self-confidence, stronger tendency to deal with problems, and higher personal control. This study utilised the statistical techniques of biserial, multi-serial, and serial correlation analysis, and revealed that industrial trainers’ problem solving styles are not significantly related to their major, grade, learning average, and teaching experience. However, results of this study indicated that male subjects are superior to female in both in overall problem solving ability and attitude. The findings also suggested that departments are significantly related to approach/avoidance style and total score of problem solving styles.
The Impact of Community-based Health Education to Improve Quality of Nursing Services for People with Hypertension : A Literature Review

Background: Essential hypertension is the most popular catastrophic case in Indonesia referred from primary health services to hospitals. High number of morbidity and mortality caused by hypertension increases financial burden of a state for catastrophic diseases. The current effort of our government to prevent and control hypertension is by health promotion through confirmation, information, and education. However, the facts that hypertension prevention keeps on developing making it a continuous global challenge for the professionals of health services. This is the reason why it's important to investigate interventions that could increase control the blood pressure. The aim of this systematic review is to gain the best literatures about health education on community-based hypertension prevention that has potential strength to regenerate clinical practice recommendations to improve preventive and promotive efforts for hypertension. Method of this literature review was using systematic searching of electronic databases from Google and Pubmed by following keywords: hypertension intervention strategies + journal, community based hypertension control programs that work + journal, hypertension AND community based health education, hypertension AND community-based nutrition DASH, hypertension AND community based control programs. Inclusion criteria of the study focused on community-based education interventions for hypertension and have completed explanation about it while exclusion criteria of the study was all articles that younger than the last 10 years. 13 articles based on the above criteria were chosen to proceed. Results of the study show that all researches were done in developed countries and most of the articles were using quantitative methods. Community-based health education for people with hypertension is an effort to help hypertension control programs. There are four health interventions related to community-based hypertension education program which are mass media campaign to reduce salt consumption, workshop programs through social volunteering or health activists, hypertension group education about DASH and lifestyle then comprehensive hypertension prevention and promotive programs. Community-based health education approaches through these interventions could be used to control the uncontrollable hypertension in the community. Multicomponent and multilevel cooperation as well as financially effective efforts to prevent, detect and manage hypertension could be gained by implementing all of these interventions.
Limited resources or limited luck? Why people perceive an illusory negative correlation between the outcomes of choice options despite unequivocal evidence for independence

When humans learn of the outcome of an option they did not choose (the alternative outcome), before their own outcome is known, they form biased expectations about their future reward. Specifically, people see an illusory negative correlation between the two outcomes, which we coined the Alternative Omen Effect (ALOE). Why does this happen? Here, we tested several alternative explanations and conclude that the ALOE may derive from a pervasive belief that good luck is a limited resource. In Experiment 1, we show that the ALOE is due to people seeing a good alternative outcome as a bad sign regarding their outcome, but not vice versa. Experiment 2 confirms that the ALOE is a highly ingrained bias that replicates across tasks, and that the ALOE cannot be explained by preconceptions regarding outcome distribution, including 1) the Limited Good Hypothesis (zero-sum bias), according to which people see the world as a zero-sum game, and assume that resources there means fewer resources here, and/or 2) a more specific assumption that laboratory tasks are programmed as zero-sum games. To neutralize these potential beliefs, participants had to draw actual colored beads from two real, distinct bags. In spite of the unequivocal situational evidence of the independence of the two resources, we found a strong ALOE. Finally, in Experiment 3, we tested the Limited Luck Hypothesis: by eliminating the value of the outcomes we eliminated the ALOE. These results suggest that individuals perceive good luck itself, rather than material goods, as a limited resource. We discuss how the Limited Luck belief might explain a wide range of behaviors traditionally associated with the Limited Good belief.
Stigma and shame attached to claiming social assistance benefits: understanding the detrimental impact on UK lone mothers’ social relationships

ABSTRACT Employing evidence from a recent qualitative study, this paper provides new insights into the social relationships of lone mothers in the UK and exposes how these relationships are negatively affected by the stigma attached to claiming social assistance benefits. The political discourse attached to welfare policy reforms has stigmatized benefit claimants as a means to activate them into paid work. Consequently, lone mothers on benefits have reported being seen primarily as failed workers and citizens, rather than as struggling mothers trying to support their children in difficult circumstances. This stigma is internalized as feelings of shame, and has damaged lone mothers’ social identity and permeated the closest of their familial relationships, highlighting the extent of its insidious and damaging power. Sadly, lone mothers and their relatives were engaged in a process of othering that only served to trap them further into stigmatizing discourses.
Strategies of responsibilization: development contributions and the political role of property developers

ABSTRACT Deliberations over property development are often typified by caricatures of the process, its actors and outcomes, with the process generally portrayed as a “development game” with planners and developers occupying opposing position. Drawing upon an examination of developers engagement with development contributions in the London Borough of Southwark, this paper draws attention to how they assume responsibility for mitigating the impacts of their developments. By exploring developers’ understandings of, attitudes toward, and interactions with development contributions, it examines how developers respond to and reflect upon this mode of intervention. It argues that the attitudes and actions of developers are neither technical or value free, but shaped by partialities that necessitate the conceptualization of the political role of developers. Whilst developers inevitably conceptualize development contributions as financial costs, they ascribe a wider set of values to these contributions, mobilizing them to serve their own interests, often revolving around building reputational capital.
The Re-consideration of Philosophy and Ethic for Operations on Cranium and Brain to Cure Drug Addiction

Recently, the brain operation to cure drug addiction has evoked nationwide repercussions, but it was banned by The Health Ministry urgently.To re-considerates it in the aspects of its history and remained issues, philosophy and ethic. It does not accord with the demand of ethics and laws and regulations to convert a clinical research issue to a clinical therapy issue without strict scientific demonstration.
Service Dogs for Veterans with PTSD: Taxonomy, Work Stress Reduction, and Matching

Service Dogs for Veterans with PTSD: Taxonomy, Work Stress Reduction, and Matching Lindsay Parenti Research suggests that many veterans with post-traumatic stress disorder (PTSD) struggle with reintegration (Sayer et al., 2010), but are unlikely to seek help or complete treatment (Schottenbauer et al., 2008). To make matters worse, available treatment options are often time consuming, challenging, and/or associated with negative side effects (Carafano & Hutchinson, 2017). Using animals as a treatment modality for veterans with PTSD is an emerging topic of interest and has shown promise (Owen, et al., 2016; Richie et al., 2016). However, several factors have hindered the advancement of this field. Obstacles include a lack of standard terminology and classification system, a need for empirical research to support the effectiveness of animal assisted interventions, and consideration of individual differences in response to animal assisted interventions. This investigation aims to fill these voids by proposing a novel taxonomy to promote research and development, describing an innovative investigation into whether the presence of a dog impacts veterans’ stress response to a task, and exploring whether the relationship between personality characteristics of service dogs and veterans impacts the success of the team. Results suggest that the demand for service dogs for veterans in the Unites States is growing and currently exceeds the supply. In addition, the inconsistent findings in the literature regarding therapeutic effects of assistance animals may be due to whether the team is compatible. This study found a potential correlation between veteran and service dog assertiveness and the benefits provided by the presence of the dog. Due to methodological concerns, results must be interpreted cautiously. More research in this area is needed, and future recommendations are provided.
Expression and clinical significance of Caspase-3 and P53 in gastric cancer

Objective To detect the expression of Caspase-3 and P53 in gastric cance tissue and normal gastric mucosa tissue,and investigate the relationship between Caspase-3,P53 and the occurrence,development of gastric cancer.Methods The expression of Caspase-3 and P53 in gastric cancer tissues and normal gastric mucosa tissues were detected by SP immunohistochemical. Results The expression of Caspase-3 positive rate in gastric cancer tissue was 30. 0%( 15 /50),in normal gastric mucosa was 70. 0%( 14 /20),there was significantly difference( P 0. 05). The positive rate of P53 in gastric cancer tissues was 76. 0%( 38 /50),in normal gastric mucosa was 25. 0%( 5 /20),there was significantly difference( P 0. 05). The positive rate of Caspase-3 and P53 were closely related to the depth of invasion,differentiation,lymph node metastasis of gastric cancer. Conclusion Caspase-3 and P53 are closely related to the occurrence and development of gastric cancer.
AB0860 A New Safety Meta-Analysis of Ketoprofen VS Ibuprofen and Diclofenac: Risk and Benefit of NON Steroidal Anti-Inflammatory Drugs beyond Efficacy Meta-Analysis

Background Over the last decades, ketoprofen, ibuprofen and diclofenac have been the most often prescribed drugs in the management of mild-to-moderate pain, chronic inflammatory and degenerative joint diseases. Objectives The aim of this study was to perform a new meta-analysis of randomised controlled trials (RCTs) in order to compare the safety of oral ketoprofen with that of ibuprofen and/or diclofenac therefore obtaining complete risk/benefit profiles of these drugs. Methods A systematic literature search was performed on main databases (Medline, Cochrane Central and Embase) until July 2013 to identify RCTs comparing directly therapeutic doses of oral ketoprofen (50-200 mg/day) vs ibuprofen (600-1800 mg/day) or diclofenac (75-150 mg/day). in accordance with the Cochrane Collaboration guideline, two rheumatologists carried out independently study selection. Results A total of 10 RCTs involving 843 patients met the inclusion criteria: six comparing ketoprofen vs ibuprofen and four comparing ketoprofen vs diclofenac. 6 of the 10 RCTs included 493 patients with systemic rheumatic diseases such as RA, OA, ankylosing spondylitis (AS), low back pain or painful shoulder. Treatments based on oral administration of ketoprofen showed a RR (Risk Ratio) of 1.02 of developing an adverse event (AE) vs treatments based on diclofenac or ibuprofen, even though there was no statistical significance in this result (P=0.91, 95% CI 0.78, 1.33). The difference between rates of AEs (Risk difference) with the three molecules was equal to 0 (P=0.91, 95% CI -0.05, 0.05), and no serious AE was observed. Moreover, there was no difference across the studies in the heterogeneity test for the safety outcome (χ2=9.07 - df=9 - P=0.43, I2 =1%), demonstrating homogeneity of trials and reliability of meta-analysis results. Conclusions Taken together, the results of this meta-analysis show that ketoprofen is well tolerated and its safety profile is comparable to ibuprofen and diclofenac, with no serious AE observed. Therefore, these data on oral ketoprofen support its recommendation in clinical practice. References Sarzi-Puttini P, et al. Efficacy of ketoprofen vs ibuprofen and diclofenac: a systematic review of the literature and meta-analysis. Clin Exp Rheumatol. 2013;31:731-8 Disclosure of Interest P. Sarzi-Puttini Grant/research support: He received a restritcted grant for study, F. Atzeni: None declared, L. Lanata Employee of: Dompe'SpA, A. Monguzzi Employee of: Dompe' SpA, M. Bagnasco Employee of: Dompe' SpA DOI 10.1136/annrheumdis-2014-eular.3690
Bridging the Opportunity Gap: College Access Programs and Outdoor Adventure Education

Students with low socioeconomic status (SES) are much less likely to participate in out-of-school-time (OST) activities than their more affluent peers. This “opportunity gap” may have compounding effects, as these activities help develop key noncognitive factors: the skills, beliefs, and behaviors associated with college readiness. College access programs may provide opportunities that are out of reach to students with low SES, including outdoor adventure education (OAE) experiences. This study involved 175 adolescents from a needs-based college access program and examined the relation of participation in a weeklong OAE experience to changes in student attitudes and beliefs, specifically (a) self-efficacy for dealing with challenge and engaging in help-seeking behaviors, (b) growth mindsets toward leadership and emotional regulation, and (c) sense of belonging within a community of learners. The study employed pre- and postcourse measures of noncognitive factors along with in-depth interviews to identify outcomes and converging results from quantitative and qualitative data. Results indicate that OAE participation relates to gains in self-efficacy for dealing with challenge and using help-seeking behavior and reinforces sense of belonging. Interviews identified that the OAE experience provides an emotionally intense and authentic practice setting where students feel impelled to overcome difficulties. Unfamiliarity with the backcountry setting necessitated that students reach out to others for assistance, remain flexible, and adapt to new environments—key skills associated with college success. Subscribe to JOREL
Programme of Eradicating Pasung in Lamongan Through Community Mental Health Nursing Approach

Background. Pasung (physical restraint) in people with mental illness is commonly found in Lamongan. In 2014, Lamongan Government launched the 2017 Lamongan Free from Pasung program based on Community Mental Health Nursing (CMHN). The aim of this program was to free all patients in pasung throughout Lamongan. The purpose of this study was to describe the evaluation results of Free from Pasung program in Lamongan. Methods. This study used a descriptive design with a retrospective observation carried out on all patients in pasung in Lamongan Community Health Center during 20142017. Results. The number of mental illness patients in 2014-2017 was 3002 patients, 186 (6.2 %) were in pasung, consisting of 127 men (68.3%) and 59 women (31.7 %). At the end of 2017, all patients in pasung had been released. Discussions. The community-based 2017 Lamongan Free from Pasung program is a very important program and has been proven to be successful in releasing all patients in Pasung. Conclusions. This program should be carried out continuously to evaluate the possibility of re-pasung cases and early detection of new pasung cases so that interventions can be carried out as early as possible. Keywords—free from pasung, mental illness, community
Factors Influencing Non-Chinese Parents Decision in Choosing National-Type Chinese Primary School (Sjkc)

National-type Chinese primary schools (SJKC) in Malaysia is more important in their role in the education of pluralism to meet the needs of diverse ethnic students as a result of the increasing response from non-Chinese parents. This paper aims to examine the factors that influence non-Chinese parents to send their children to National-type Chinese primary schools in Malaysia who place greater emphasis on the Chinese language and influence their children's worldview towards community and ethnic relations. The empirical findings show that among the factors that drove non-Chinese parents to send their children to the SJKC were the quality and diversity factors in the SJKC, the ecological environment factors as well as the importance of mastering the Chinese language in the era of globalization. The findings of this study refer to previous studies and scholarly articles. Throughout the explanation, it is hoped that this guide will help to inspire non-Chinese parents in ensuring that their children enjoy a quality education and contribute to the nation in the process of nation-building.
Association of PPARγ2 gene Pro12Ala polymorphism in type 2 diabetes with coronary heart disease

AIM:To determine frequencies distribution of peroxisome proliferator activated receptorγ2(PPARγ2) gene pro12Ala polymorphism genotype and allele and relationship in type 2 diabetes mellitus(T2DM) with coronary heart disease(CHD). METHODS:Polymerase chain reaction(PCR)-restrion fragment length polymorphism was used to determine the distribution of allele and genotype frequencies of Pro12Ala polymorphism in(PPARγ2) gene in 288 patients with T2DM and 258 patients with T2DM and CHD,case-contrast analysis was used to study the association between Pro12 Ala polymorphism in T2DM and CHD and T2DM.RESULTS:The 12 Ala allele frequencies in T2DM groups was 6.3%and in T2DM and CHD groups was 3.9%(P=0.157),The 12 Ala allele was less frequent in the T2DM and CHD patients than in the T2DM subjects.CONCLUSION:The PPARγ 12Ala allele was not associated with coronary heart disease in type 2 diabetes mellitus.