Miracle-dz/UniFAR-FTUs huggingface dataset:
Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome

The argument is frequently made that the amyloid-β protein (Aβ) persists in the human genome because Alzheimer’s disease (AD) primarily afflicts individuals over reproductive age and, therefore, there is low selective pressure for the peptide’s elimination or modification. This argument is an important premise for AD amyloidosis models and therapeutic strategies that characterize Aβ as a functionless and intrinsically pathological protein. Here, we review if evolutionary theory and data on the genetics and biology of Aβ are consistent with low selective pressure for the peptide’s expression in senescence. Aβ is an ancient neuropeptide expressed across vertebrates. Consistent with unusually high evolutionary selection constraint, the human Aβ sequence is shared by a majority of vertebrate species and has been conserved across at least 400 million years. Unlike humans, the overwhelming majority of vertebrate species do not cease reproduction in senescence and selection pressure is maintained into old age. Hence, low selective pressure in senescence does not explain the persistence of Aβ across the vertebrate genome. The “Grandmother hypothesis” (GMH) is the prevailing model explaining the unusual extended postfertile period of humans. In the GMH, high risk associated with birthing in old age has lead to early cessation of reproduction and a shift to intergenerational care of descendants. The rechanneling of resources to grandchildren by postreproductive individuals increases reproductive success of descendants. In the GMH model, selection pressure does not end following menopause. Thus, evolutionary models and phylogenetic data are not consistent with the absence of reproductive selection pressure for Aβ among aged vertebrates, including humans. Our analysis suggests an alternative evolutionary model for the persistence of Aβ in the vertebrate genome. Aβ has recently been identified as an antimicrobial effector molecule of innate immunity. High conservation across the Chordata phylum is consistent with strong positive selection pressure driving human Aβ’s remarkable evolutionary longevity. Ancient origins and widespread conservation suggest the human Aβ sequence is highly optimized for its immune role. We detail our analysis and discuss how the emerging “Antimicrobial Protection Hypothesis” of AD may provide insights into possible evolutionary roles for Aβ in infection, aging, and disease etiology.
Dynamic Regulation of Level Set Parameters Using 3D Convolutional Neural Network for Liver Tumor Segmentation

Segmentation of liver tumors plays an important role in the choice of therapeutic strategies for liver disease and treatment monitoring. In this paper, we generalize the process of a level set with a novel algorithm of dynamic regulation to energy functional parameters. The presented method is fully automatic once the tumor has been detected. First, a 3D convolutional neural network with dense layers for classification is used to estimate current contour location relative to the tumor boundary. Second, the output 3D CNN probabilities can dynamically regulate parameters of the level set functional over the process of segmentation. Finally, for full automation, appropriate initializations and local window size are generated based on the current contour position probabilities. We demonstrate the proposed method on the dataset of MICCAI 2017 LiTS Challenge and 3DIRCADb that include low contrast and heterogeneous tumors as well as noisy images. To illustrate the strength of our method, we evaluated it against the state-of-the-art methods. Compared with the level set framework with fixed parameters, our method performed better significantly with an average DICE improvement of 0.15. We also analyzed a challenging dataset 3DIRCADb of tumors and obtained a competitive DICE of 0.85 ± 0.06 with the proposed method.
Racial and Ethnic Differences in Alzheimer’s Disease Knowledge Among Community-Dwelling Middle-Aged and Older Adults in Florida

Objective: To compare Alzheimer’s disease (AD) knowledge by race and ethnicity in a community sample of middle-aged and older adults aged 50 and over in Florida. Method: Data from HealthStreet, a University of Florida community engagement program, which uses community health workers to assess the health conditions, concerns, and knowledge of community members, was used (n = 842). A multivariate regression model was used to quantify differences in AD knowledge by race and ethnicity. Results: Older age and recruitment from Miami were associated with higher AD knowledge while being non-Hispanic Black, reporting male sex, having less than high school diploma, and reporting food insecurity were associated with lower AD knowledge. Discussion: Hispanics had comparable AD knowledge to non-Hispanic Whites and more knowledge than non-Hispanic Blacks after adjusting for other factors that could differentiate these groups. Almost half of the participants did not know hypertension is a risk factor for AD, highlighting a point of intervention.
Kinematic and Kinetostatic Analysis of Parallel Manipulators with Emphasis on Position, Motion, and Actuation Singularities

Summary This paper provides a contribution to the singularity analysis of the parallel manipulators by introducing the position singularities in addition to the motion and actuation singularities. The motion singularities are associated with the linear velocity mapping between the task and joint spaces. So, they are the singularities of the relevant Jacobian matrices. On the other hand, the position singularities are associated with the nonlinear position mapping between the task and joint spaces. So, they are encountered in the position-level solutions of the forward and inverse kinematics problems. In other words, they come out irrespective of the velocity mapping and the Jacobian matrices. Considering these distinctions, a kinematic singularity is denoted here by one of the four acronyms, which are PSFK (position singularity of forward kinematics), PSIK (position singularity of inverse kinematics), MSFK (motion singularity of forward kinematics), and MSIK (motion singularity of inverse kinematics). There may also occur an actuation singularity (ACTS) concerning the kinetostatic relationships that involve forces and moments. However, it is verified that an ACTS is the same as an MSFK. Each singularity induces different consequences in the joint and task spaces. A PSFK imposes a constraint on the active joint variables and makes the end-effector position indefinite and uncontrollable. Therefore, it must be avoided. An MSFK imposes a constraint on the rates of the active joint variables and makes the end-effector motion indefinite and easily perturbable. Besides, since it is also an ACTS, it causes the actuator torques or forces to grow without bound. Therefore, it must also be avoided. On the other hand, a PSIK imposes a constraint on the end-effector position but provides freedom for the active joint variables. Similarly, an MSIK imposes a constraint on the end-effector motion but provides freedom for the rates of the active joint variables. A PSIK or MSIK need not be avoided if the constraint it imposes on the position or motion of the end-effector is acceptable or if the task can be planned to be compatible with that constraint. Besides, with such a compatible task, a PSIK or MSIK may even be advantageous, because the freedom it provides for the active joint variables can sometimes be used for a secondary purpose. This paper is also concerned with the multiplicities of forward kinematics in the assembly modes of the manipulator and the multiplicities of inverse kinematics in the posture modes of the legs. It is shown that the assembly mode changing poses of the manipulator are the same as the MSFK poses, and the posture mode changing poses of the legs are the same as the MSIK poses.
Where does the time go? An experimental test of what social media displaces and displaced activities’ associations with affective well-being and quality of day

Drawing from media displacement theory, this article explores which activities are displaced when individuals spend time on social media. Community and undergraduate participants (N = 135) were randomly assigned to five conditions: no change in social media use, or abstinence from social media for 1 week, 2 weeks, 3 weeks, or 4 weeks. Participants completed a daily diary measuring how they spent time each day, affective well-being, and quality of day for 28 days. The results indicate that abstinence from social media increased time spent engaged in seven activities, primarily browsing the Internet, working, childcare, and cooking/cleaning. In addition, associations among psychosocial outcomes and the displaced activities were examined. Time spent working, sleeping, and cooking/cleaning were negatively associated with affective well-being and quality of day. On days participants used social media, minutes of use were negatively associated with quality of day. The results suggest that social media primarily displaces unpleasant or neutral activities.
Reducing Potentially Inappropriate Medications in Older Adults: A Way Forward

RÉSUMÉ La réduction des médicaments potentiellement inappropriés (MPI) chez les personnes âgées est un enjeu important selon de nombreux cliniciens et chercheurs à travers le monde, car ces médicaments accroissent significativement la morbidité et la mortalité dans la population plus âgée. La prévalence des MPI est un problème répandu malgré l’existence de plusieurs critères explicites et implicites de réduction des MPI chez les personnes âgées, les plus courants étant les critères de Beers, les critères STOPP/START et plusieurs critères nationaux spécifiques. Cette revue non systématique visait à examiner les critères de référence pour la réduction des MPI et à clarifier le rôle de certaines mesures, dont la déprescription, pour optimiser la prescription des médicaments chez les personnes âgées. Des recherches par mots-clés et termes MeSH ont été menées dans des bases de données électroniques. Les nombreux critères disponibles ont chacun leurs avantages et inconvénients. La déprescription, qui vise à réduire l’utilisation des MPI, a considérablement gagné en importance dans les initiatives associées à l’amélioration des pratiques de prescription. La déprescription est une approche méthodique qui implique l’arrêt graduel, éclairé et individualisé des médicaments inappropriés, avec un suivi rigoureux des patients pour assurer la détection d’événements indésirables ou de symptômes de rebond. Une approche combinée centrée sur le patient et le soignant favorise la collaboration entre les prescripteurs et les pharmaciens afin de réduire le nombre de MPI chez les personnes âgées. ABSTRACT Reducing potentially inappropriate medications (PIMs) in older adults is an area of sustained interest for many clinicians and researchers across the globe, as PIMs contribute to a significant burden of morbidity and mortality in the aging population. The prevalence of PIMs is a pervasive problem despite the presence of several explicit and implicit criteria for reducing PIMs in older adults, the most common being the Beers criteria, the Screening Tool of Older Persons’ potentially inappropriate Prescriptions/Screening Tool to Alert doctors to the Right Treatment (STOPP/START) criteria, and several country-specific criteria. This narrative review aims to discuss the frequently used published criteria for reducing PIMs, and elucidates the role of certain measures, especially de-prescribing, to optimise medication prescription in older adults. Electronic databases were searched using keywords and MeSH terms. The numerous available criteria have their specific advantages and drawbacks. De-prescribing, an initiative to reduce the use of PIMs, has gained significant importance in improving appropriate prescribing practices. De-prescribing is a methodical approach to gradually stopping inappropriate medications judiciously for each patient and simultaneously monitoring the patient carefully for the onset of adverse events or rebound symptoms. A combined caregiver–patient-centred approach encourages the collaboration between prescribers and pharmacists to reduce PIMs in older adults.
Early gastric cancer diagnostic ability of ultrathin endoscope loaded with laser light source

BACKGROUND Conventionally, the low luminous intensity, low image resolution, and difficulty in operation have been reported with the ultrathin endoscope. However, it has markedly advanced recently. The improvement of the diagnostic ability is expected. AIM To compare the early gastric cancer diagnostic ability of an ultrathin endoscope loaded with a laser light source and that of the conventional endoscope. METHODS The target subjects were 375 consecutive patients who underwent endoscopy at our hospital for post-endoscopic submucosal dissection follow-up of gastric cancer from January to August 2018. During endoscopy, the ultrathin endoscope was used in 140 patients (37.3%), and the conventional endoscope was used in 235 patients (62.7%). Patient background was adjusted using the propensity score matching method, and gastric cancer detection ability was evaluated in the two groups. RESULTS The gastric cancer detection rate was 7.8% in the ultrathin endoscope group and 7.0% in the conventional endoscope group, and the mean intragastric observation time was 4.1 ± 1.7 min in the ultrathin endoscope group and 4.1 ± 1.9 min in the conventional endoscope group, showing no significant differences between the groups. Moreover, the biopsy implementation rate was 31.8% in the ultrathin endoscope group and 41.1% in the conventional endoscope group, and the biopsy prediction rate was 17.9% and 13.2%, respectively, showing no significant differences between the groups. CONCLUSION The gastric cancer diagnostic ability of the ultrathin endoscope loaded with a laser light source was comparable to that of the conventional endoscope. The observation time was also comparable. Thus, endoscopy using the ultrathin endoscope loaded with the laser light source would be the first option in screening examinations of gastric cancer due to its low invasion.
Precision nitrogen management improves grain yield, nitrogen use efficiency and reduces nitrous oxide emission from soil in spring maize

Abstract Precision nitrogen (N) management sustains high grain yield with low N optimum dose and thus may help reduce the escape of reactive nitrogen from soils to the atmosphere. Two-year field studies were conducted at two locations in sub-tropical and sub-humid climate in Indo-Gangetic plains of South Asia with the objectives to establish precision N management technology for fertilizer N topdressings in spring maize while quantifying nitrous oxide emission from soil. A significant positive correlation of 0.64 to 0.90 between LCC (Leaf color chart) scores and leaf N concentrations at different growth stages indicated that LCC scores can successfully be used as an index of leaf N content for precision N management in spring maize. A close linear relationship (R2 = 0.75) between chlorophyll meter (SPAD) readings and LCC score showed that like SPAD meter, LCC score can reliably consider leaf greenness as an indicator of leaf N concentration. Cate-Nelson plot of LCC scores verses relative grain yield expressed LCC score 5 as the threshold for sustaining potential yield. Fertilizer N topdressings based on threshold leaf greenness of LCC 5 produced 6 to 10 percent higher grain yield with improved recovery and agronomic efficiencies in comparison to soil-test based N recommendations. Nitrous oxide emission estimated using Cool Farm Tool (CFT); an empirical model specified that application of 120 kg N ha−1 at LCC 5 down turned nitrous oxide emission by 8.0 percent compared to soil test-based N management.
Effects of handling and short-term captivity: a multi-behaviour approach using red sea urchins, Mesocentrotus franciscanus

Understanding the effects of captivity-induced stress on wild-caught animals after their release back into the wild is critical for the long-term success of relocation and reintroduction programs. To date, most of the research on captivity stress has focused on vertebrates, with far less attention paid to invertebrates. Here, we examine the effect of short-term captivity (i.e., up to four days) on self-righting, aggregation, and predator-escape behaviours in wild-caught red sea urchins, Mesocentrotus franciscanus, after their release back into the wild. Aggregation behaviour, which has been linked to feeding in sea urchins, was not affected by handling or captivity. In contrast, the sea urchins that had been handled and released immediately, as well as those that were handled and held captive, took longer to right themselves and were poorer at fleeing from predators than wild, unhandled sea urchins. These results indicate that handling rather than captivity impaired these behaviours in the short term. The duration of captivity did not influence the sea urchin behaviours examined. Longer-term monitoring is needed to establish what the fitness consequences of these short-term behavioural changes might be. Our study nevertheless highlights the importance of considering a suite of responses when examining the effects of capture and captivity. Our findings, which are based on a locally abundant species, can inform translocation efforts aimed at bolstering populations of ecologically similar but depleted invertebrate species to retain or restore important ecosystem functions.
Worker Size, Geographical Distribution, and Introgressive Hybridization of Invasive Solenopsis invicta and Solenopsis richteri (Hymenoptera: Formicidae) in Tennessee

Abstract Worker size and geographical distribution of red imported fire ants (Solenopsis invicta Buren), black imported fire ants (Solenopsis richteri Forel), and their hybrid (S. invicta × S. richteri) (Hymenoptera: Formicidae) were evaluated from colonies sampled across Tennessee. The fire ant species and hybrid status were determined using cuticular hydrocarbon and venom alkaloid indices obtained from gas chromatography and mass spectrometry. Hybrids were the most common fire ant throughout Tennessee. With the exception of a few isolated S. invicta samples, only hybrids were found in east Tennessee, and hybrids predominated in middle Tennessee. In west Tennessee, mixed populations of S. richteri and hybrids were found. Hybrids were more common in west Tennessee than a survey performed a decade earlier. No statistical differences were detected in the average inter-colonial worker size of S. richteri and hybrids. Likewise, average worker size was not related to geographic location in Tennessee. The similarity in average worker size among hybrid colonies with a wide range of cuticular hydrocarbon and venom alkaloid values suggests introgression was not impacting ant size in colonies sampled throughout Tennessee.
Exploring Reasons for Low Attendance of Mothers to Growth Monitoring and Promotion Program at Loka Abaya District, Southern Ethiopia: Exploratory Qualitative Study

Background Different organizations in Ethiopia are currently working on prevention and promotion activities to fight malnutrition among children through a community-based nutrition program. One of these activities with little success is growth monitoring and promotion (GMP). Exploring the reason and better understanding of low attendance of mothers to the GMP program can help to improve the program by incorporating finding. The aim of the study was to explore reasons for low attendance to the GMP program among mothers of under-two children. Method An exploratory qualitative study design was used to unearth reasons for low attendance of mothers with under-2-year-old child to the GMP program. In-depth interviews were carried out with 13 mothers. The data were analyzed using qualitative content analysis approach. Result Mothers perceived that GMP is (meant) for unhealthy children (only). Again mothers mentioned community dishonor of mothers with wasted children and method of weighing a child as a community-related reason for low attendance to the GMP program. They also indicated that there was no community conversation and weak counseling of the mothers about child feeding and growth. Perception about “evil eye” was also indicated as a reason for lower attendance of the program. Conclusion Mothers showed that there was lack of knowledge about GMP. Limited community conversation and weak counseling about child nutrition as a GMP program were explored reasons for low attendance. Other reasons mentioned by the mothers were consideration of “evil eye” and method of weighing a child. Further research is needed to explore the implementation of GMP by health workers and to evaluate the extent of the identified reasons for low attendance to the GMP program by the mother.
Anomalous cluster detection in spatiotemporal meteorological fields

Finding anomalous regions in spatiotemporal climate data is an important problem with a need for greater accuracy. The collective and contextual nature of anomalies (e.g., heat waves) coupled with the real‐valued, seasonal, multimodal, highly correlated, and gridded nature of climate variable observations poses a multitude of challenges. Existing anomaly detection methods have limitations in the specific setting of real‐valued areal spatiotemporal data. In this paper, we develop a method for extreme event detection in meteorological datasets that follows from well known distribution‐based anomaly detection approaches. The method models spatial and temporal correlations explicitly through a piecewise parametric assumption and generalizes the Mahalanobis distance across distributions of different dimensionalities. The result is an effective method to mine contiguous spatiotemporal anomalous regions from meteorological fields which improves upon the current standard approach in climatology. The proposed method has been evaluated on a real global surface temperature dataset and validated using historical records of extreme events.
Impact of chrysin on the molecular mechanisms underlying diabetic complications

Diabetes mellitus is a chronic metabolic disorder, resulting in high morbidity and mortality worldwide. Neuropathy, ocular diseases, kidney diseases, and cardiovascular disease are common complications of diabetes that threats the patient’s life. Chrysin (CH), a natural flavonoid, has several pharmacological effects, including antioxidant, antiapoptotic, anti‐inflammatory, and anticancer. Strong scientific documents indicated that chrysin may be effective for preventing and treating complications of diabetes in experimental models. The present study was designed to review the association between chrysin administration and diabetes complications by focusing on the possible molecular pathway. The findings indicate that chrysin has protective effects against diabetes outcomes by modulating oxidative stress, inflammation, and apoptosis in animal models. However, more clinical trial study should be done to clear the protective effects of chrysin in diabetic patients.