Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiviteit van online cognitieve gedragstherapie voor depressie in de eerste lijn.

Gecomputeriseerde cognitieve gedragstherapie (CCGT) kan mogelijk een oplossing bieden voor de huidige onderbehandeling van depressie. Het doel van dit onderzoek is het vaststellen van de klinische effectiviteit van online, onbegeleide CCGT voor eerstelijnsbehandeling van depressie. Daartoe werden 303 depressieve patienten willekeurig verdeeld over (a) Kleur Je Leven (KJL), (b) de gebruikelijke zorg door de huisarts (‘Treatment as Usual' = TAU) of (c) een combinatie van KJL en TAU. KJL is een online, interactief, multimedia CCGT programma. Er werd geen begeleiding geboden. Er was een follow-up periode van 6 maanden. Er werden bij de intention-to-treat-analyses en de per-protocol analyses geen significante verschillen vastgesteld tussen de drie interventies. De online, onbegeleide CCGT liet geen betere resultaten zien dan de gebruikelijke zorg door de huisarts, en de combinatie van beide liet geen aanvullende effecten zien. De afname van depressieve symptomen bij matig tot ernstig depressieve patienten was in alle drie de interventies matig. Online CCGT zonder begeleiding is niet geschikt voor alle depressieve patienten.
Frequency-response-associated delay-dispersion issue in time-delay measuring sensors

We investigated the extent of the measurement error of a time-delay measuring sensor caused by the frequency-response-associated delay-dispersion issue. We considered the possible shapes of the frequency response of stable linear circuits and the possible shapes of a step signal. In general, systems with wider input bandwidth and whose input frequency response has a smaller peak are more accurate. The maximum potential amount of error caused by this issue is related to the 10–90% transition time of the system's input step response. For measurements referenced to the 50% level of the input signals' step size, this will be ∼1/3× and closer to 1× the transition time in the case of systems without and with significant ringing, respectively.
Ready, Set…Poised!: Polycomb target genes are bound by poised RNA polymerase II throughout differentiation

In embryonic stem cells (ESCs), silent genes with major developmental functions display a unique epigenetic state in which strong and broad binding by Polycomb repressive complexes (PRCs) is accompanied by the presence of poised RNA polymerase II (RNAPII) and activating histone marks (e.g. H3K4me3) (Azuara et al, ; Bernstein et al, ; Stock et al, ; Brookes et al, ). It has been suggested that the plasticity and broad differentiation potential of pluripotent cells might rely, at least partly, on this unique epigenetic state (Bernstein et al, ; Stock et al, ). In their recent study, Pombo and colleagues (Ferrai et al, ) show that a similar epigenetic state can be found at a subset of major developmental genes throughout the differentiation of ESCs into neurons, providing novel and exciting insights into the molecular basis of cellular plasticity in differentiated cells.
Intracameral Amphotericin B: Initial Experience in Severe Keratomycosis

Purpose. Fungal keratitis is a significant cause of ocular morbidity in India. The most commonly implicated fungi are Aspergillus spp. Patients often present with hypopyon, which usually contains fungal elements. The treatment is difficult owing to poor intraocular penetration of most available antifungal agents. This study evaluated the results of intracameral injection of amphotericin B in natamycin resistant cases of severe keratomycosis. Methods. Three patients of culture proven Aspergillus flavus corneal ulcer with hypopyon not responding to topical natamycin 5%, amphotericin B 0.15%, and oral itraconazole were administered intracameral amphotericin B. The first case received 7.5 &mgr;g in 0.1 mL followed by two subsequent injections of 10 &mgr;g in 0.1 mL each, the second case received two injections of 10 &mgr;g in 0.1 mL, and the third patient received a single dose of 10 &mgr;g in 0.1 mL. Culture of the aqueous sample also grew A. flavus in all three cases. Results. All three cases responded favorably, with the ulcer and hypopyon clearing completely. There was no clinical evidence of corneal or lenticular toxicity in any patient. Conclusions. Intracameral amphotericin B may be a useful modality in the treatment of severe keratomycosis not responding to topical natamycin. It ensures adequate drug delivery into the anterior chamber and may be especially useful to avoid surgical intervention in the acute stage of the disease.
Organisation du suivi des prescriptions hors AMM en cancérologie : illustration par une analyse des prescriptions de six biothérapies en région Haute-Normandie et comparaison France/Europe

Les prescriptions hors referentiels (hors AMM et hors PTT/RTU) sont frequentes en cancerologie. Un recueil national des prescriptions de six biotherapies de la liste en sus a ete mis en place et coordonne par les OMEDIT en lien avec l’INCa. Cette these presente la methodologie de ce travail de recueil de donnees et les resultats pour la region Haute-Normandie. Durant la periode de l’etude (decembre 2013-fevrier 2014), 617 prescriptions (initiation de traitement uniquement) ont ete realisees pour les 6 biotherapies concernees (bevacizumab, pemetrexed, rituximab, cetuximab, panitumumab et trastuzumab). Au total, 75,2% des prescriptions respectent le cadre de l’AMM, 2,2% celui d’un PTT et 22,2% correspondent a des prescriptions hors referentiels. Le taux de prescriptions hors referentiels etait variable selon les molecules. La majorite des situations cliniques dans lesquelles une prescription hors referentiels est realisee correspond a des situations decrites dans les RBU et/ou validees par des recommandations internationales. Les resultats nationaux de ce travail permettront de completer cette analyse regionale et de comparer les pratiques de prescription entre regions. Par ailleurs, nous avons interroge des pharmaciens travaillant en oncologie a travers l’Europe afin de comparer les organisations pour le suivi des prescriptions hors AMM, les modalites d’acces au remboursement et le role des pharmaciens en cancerologie face a ce type de prescriptions. A la lumiere des reponses recues, il apparait d’importantes disparites de fonctionnement entre systemes de sante notamment sur les modalites de financement et de controle des prescriptions hors referentiels. L’implication du pharmacien dans la prise en charge du patient semble egalement variable au sein de l’Union Europeenne, bien que la majorite de ceux-ci souhaitent developper leur role vers une plus grande implication au sein des services de soins.
Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction

Transcription factors belonging to the FoxH1 and Mixer families are required for facets of Nodal signaling during vertebrate mesendoderm induction. Here, we analyze whether zebrafish proteins related to FoxH1 [Schmalspur (Sur)] and Mixer [Bonnie and clyde (Bon)] act within or downstream of the Nodal signaling pathway, test whether these two factors have additive or overlapping activities, and determine whether FoxH1/Sur and Mixer/Bon can account for all Nodal signaling during embryogenesis. We find that sur expression is independent of Nodal signaling and that bon is expressed in the absence of Nodal signaling but requires Nodal signaling and Sur for enhanced, maintained expression. These results and the association of FoxH1 and Mixer/Bon with phosphorylated Smad2 support a role for these factors as components of the Nodal signaling pathway. In contrast to the relatively mild defects observed in single mutants, loss of both bon and sur results in a severe phenotype characterized by absence of prechordal plate, cardiac mesoderm, endoderm and ventral neuroectoderm. Analysis of Nodal-regulated proteins reveals that Bon and Sur have both distinct and overlapping regulatory roles. Some genes are regulated by both Bon and Sur, and others by either Bon or Sur. Complete loss of Nodal signaling results in a more severe phenotype than loss of both Bon and Sur, indicating that additional Smad-associated transcription factors remain to be identified that act as components of the Nodal signaling pathway.
The acid and alkaline phosphatase activity in the normal and recovering liver of the rat

Surgical removal of as much as 75% of the hepatic parenchyma in the rat is followed immediately by compensatory hyperplasia, resulting in complete restoration by weight of the liver within 28 days (Higgins and Anderson, '31). The restoration is brought about by mitotic division (Beams and King, '42) of the remaining hepatic cells (Sulkin, '43). According to Beams and King ('42)' binucleate cells divide synchronously, but usually only 1 spindle is formed at metaphase so that either 2 tetraploid cells result froin a complete mitosis, or cytokinesis may be suppressed, thus' giving rise to a binucleate cell with 2 tetraploid nuclei. Sulkin ( '43) reported that the frequency and magnitude of polyploidp is increased in the restored liver and this increase is found principally in the regions of the central veins. Although there are a number of reports in the literature dealing with phospliatase in the normal liver (Gomori, '41 ; Kabat and Furth, '41 ; Wolf, Kabat and Wewman, '43 ; Dempsey and Deaiie, '46; Deane, '47) and with changes of acid or alkaline phosphatase in pathologies of the liver and in abnormal growths (Wachstein, '45 ; Greenstein et al., '42, '43, '44, '46; Kabat and Furth, '41; Kohler, '40)' there is no de-
Multistability in Piecewise Linear Systems versus Eigenspectra Variation and Round Function

A multistable system generated by Piecewise Linear (PWL) subsystems based on the jerk equation is presented. The system’s behavior is characterized by means of the Nearest Integer or the round(x) function to control the switching events and to locate the corresponding equilibria on each of the commutation surfaces. These surfaces are generated through the switching function dividing the space into regions equally distributed along one axis. The trajectory of the system is governed by the eigenspectrum of the coefficient matrix, which can be adjusted by a bifurcation parameter. The behavior of the system can change from multiscroll oscillations in a mono-stable state into the coexistence of several single-scroll attractors in multistable states. The dynamics and bifurcation analysis are illustrated by numerical simulations to depict the multistable states.
The p110 (cid:2) Isoform of Phosphatidylinositol 3-Kinase Is Essential for Polyomavirus Middle T Antigen-Mediated Transformation (cid:1)

Middle T antigen (MT) of polyomavirus is known to play an important role in virus-mediated cellular transformation. While MT has been extensively examined in spontaneously immortalized rodent ﬁbroblasts, its interactions with cells of other types and species are less well understood. We have undertaken a cross-species and cross-cell-type comparison of MT-induced transformation in cells with genetically deﬁned backgrounds. We tested the transforming abilities of a panel of MT mutants, Y250F, Y315F, and Y322F, that are selectively mutated in the binding sites for the principal effectors of MT—Src homology 2 domain-containing transforming protein, phosphatidylinositol 3-kinase (PI3K), and phospholipase C- (cid:1) , respectively—in ﬁbroblasts and epithelial cells of murine or human origin. We found that the Y315F mutation disabled the ability of MT to induce transformation in all cell types and species tested. While Y315F also failed to activate the PI3K pathway in these cells, genetic evidence has indicated Y315 may make other contributions to transformation. To conﬁrm the role of PI3K, the PIK3CA gene, encoding p110 (cid:2) , the prime effector of PI3K signaling downstream from activated growth factor receptors, was genetically ablated. This abolished the transforming activity of MT, demonstrating the essential role for this PI3K isoform in MT-mediated transformation. The Y250F mutant was able to transform the human, but not the murine, cells that were examined. Interestingly, this mutant fully activates the PI3K pathway in human cells but activated PI3K signaling poorly in the murine cells used in the study. This again points to the importance of PI3K activation for transformation and suggests that the mechanism by which MT activates the PI3K pathway differs in different species.
A proposal for the cutoff point of waist circumference for the diagnosis of metabolic syndrome in the Japanese population.

O ver the past 2 decades, there has been a dramatic increase in the number of subjects with the metabolic syndrome in Japan as well as in Western countries. Because subjects with the metabolic syndrome have an elevated risk of development of type 2 diabetes and cardiovascular diseases (1–3), there is an urgent need to establish strategies to prevent an epidemic of this syndrome. In particular, a practical and sensitive screening system must be established to detect the metabolic syndrome. At present, there are two internationally recognized definitions of the metabolic syndrome, namely those of the World Health Organization (4) and the National Cholesterol Education Program’s Adult Treatment Panel III (NCEP III) (5). In an attempt to establish a unified definition for the metabolic syndrome, the International Diabetes Federation (IDF) has very recently announced a new definition of the metabolic syndrome that is expected to be suitable for use in clinical practice worldwide (6). The IDF defines metabolic syndrome as the presence of central obesity plus any two of the following four factors (raised triglyceride level, reduced HDL cholesterol, raised blood pressure, and raised fasting plasma glucose). The IDF recommended that the cutoff level used for the waist circumference to define central obesity should be different among different ethnic groups (7). In fact, the new IDF definition has proposed ethnicity-specific cutoff values for waist circumference, namely, 94 and 80 cm for European men and women, respectively, and 85 and 90 cm for Japanese men and women, respectively. Nonetheless, the IDF has strongly recommended that more extensive investigations should be performed before suitable cutoff levels are established for use in clinical practice (7). In this study, we investigated the relationship between the cutoff values used for the waist circumference to define central obesity and rates of detection of subjects having multiple risk factors of the metabolic syndrome and attempted to determine the most suitable cutoff level of waist circumference for the diagnosis of metabolic syndrome in a communitybased cohort.
Genetic analysis of ethylene regulation of legume nodulation

The gaseous hormone ethylene has multiple roles in plant development and responses to external cues. Among these is the regulation of ‘Rhizobium’-induced nodulation in legumes. Extensive descriptive literature exists, but has been expanded to allow more mechanistic analysis through the application of genetics. Both mutants and transgenics displaying ethylene insensitivity have now been described, suggesting an intimate interplay of ethylene response, plant development and nodulation.
Improved Planning and Filtering Algorithm for Task-priority Redundancy Resolution in Mobile Manipulation

Discrete time implementation of task-priority redundancy resolution using closed loop inverse kinematics with fixed sampling time may lead to discretization chatter. The chattering effect is due to switching between different closed loop behaviours whenever the corresponding external event has occurred. This effect causes high frequency oscillation with finite frequency and amplitude in both joint space motion and operational space motion which is highly undesired. In this paper, we propose a planning and filtering algorithm to improve the robustness of task-priority redundancy resolution without having the effect of chattering, while combining multiple closed loop behaviours. We also show how the null space projection in taskpriority control affects the operational space motion while switching between the behaviours. To demonstrate the effectiveness of the proposed algorithm, three different case studies are presented for a planar mobile manipulator with holonomic constraint. The results confirm that the proposed algorithm eliminates the chatter and moves the end effector on a smooth trajectory.
Increasing diagnosis of subclinical thyroid cancers leads to spurious improvements in survival rates

Survival rates are commonly used to measure success in treating cancer, but can be misleading. Modern diagnostic practices can lead to the appearance of improving cancer survival, as tumors are diagnosed earlier (lead‐time bias) or as an increasing proportion are slow‐growing (length bias), whereas the actual burden of cancer deaths is unchanged. Increasingly, more subclinical thyroid cancers are being diagnosed. The objective of the current study was to determine whether thyroid cancer survival rates have been affected by this phenomenon.
Hybrid function projective synchronization in discrete dynamical networks via adaptive control

In this paper, we study the hybrid function projective synchronization between coupled complex discrete networks with different dimensions. The hybrid function projective synchronization is achieved by designing an adaptive control method. Based on the designed controller and the Lyapunov stability theory, we derive sufficient conditions to realize the hybrid function projective synchronization with different nodes. Moreover, with the adaptive update law, an adaptive control gains are obtained. Furthermore, we examine different cases of outer coupling matrix of node dynamics. Finally, we provide numerical examples to show the effectiveness of the proposed control scheme. c ©2017 All rights reserved.
Efecto de la sustitución parcial de la proteína de la dieta por urea sobre el consumo voluntario de materia seca y respuesta productiva de corderos

Para evaluar el efecto de la sustitucion del nitrogeno de la proteina preformada del suplemento por urea (U) sobre el consumo voluntario y ganancia diaria de peso (GDP) en corderos, se realizaron dos experimentos en la Unidad de Produccion de Ovinos del Ceniap-INIA. En el primero, veinte corderos de la raza West African con un peso promedio de 21±1,5 kg fueron asignados a cinco dietas donde se sustituyo el nitrogeno de la fuente proteica, harina de pescado (HP). En el segundo, veinte corderos de la raza West African con un peso promedio de 14±0,5 kg, se asignaron a cinco dietas, donde se sustituyo el nitrogeno de la fuente proteica harina de soya (HS). En ambos experimentos, los niveles de inclusion de la urea fueron 0; 1; 1,5; 2 Y 3% del suplemento. Todos los animales recibieron el suplemento a razon de 300 g/dia y heno repicado de pasto bermuda (Cynodon dactylon) ad libitum. En el Experimento 1 con HP, los consumos de MS resultaron similares con un valor promedio de 904,2 ± 43 g/dia. La GDP (g/dia) fue diferente entre los tratamientos (P<0,05), siendo mayores para los tratamientos con 1,5 (60,0); 2 (67,5) y 3% U (61.0). El nivel de 1 % U (32,5) resulto similar al control (40,0). Igualmente, la conversion se vio favorecida en los tratamientos con 1,5; 2 y 3% U, con valores de 16, 15,5 y 14,8, respectivamente. En el experimento 2, se observaron diferencias (P<0.05) entre el control (0% U) y el nivel de 1 % U para el consumo de la MS total (631,8 vs. 763,0 g/dia). Niveles superiores de sustitucion representaron valores intermedios (654,8; 688,4 y 717,7 g/dia, para los niveles de sustitucion de 1,5; 2 Y 3% U en el suplemento, respectivamente. La GDP resulto diferente entre los tratamientos (P<0,05), con la mejores ganancias para el tratamiento con 1% U (98,8 g/dia). La GDP para el nivel 1,5% U (75,4 g/dia) resulto semejante al tratamiento control (75,0 g/dia). Niveles superiores de sustitucion resultaron en ganancias intermedias (87,9 Y 88,8 g/dia para los tratamientos con 2 y 3% de U, respectivamente). En este experimento, las conversiones alimenticias fueron similares entre los tratamientos con un valor promedio de 8,3. Independientemente de la fuente proteica, en la experiencia la proteina preformada pudo ser sustituida en la racion diaria por urea, sin detrimento del crecimiento de los corderos, hasta en un 25%.
Inter-observer and intra-observer variability in hepatology

Objectives A determination of the inter-observer variability is an important step before determining diagnostic accuracy and requires a specific methodology and statistical tests. The aim of this study was to report the results, characteristics and methodological quality of agreement studies performed in hepatology. Methods A search of published studies yielded 42 that could be used in this evaluation: three were clinical studies, 11 were in the field of endoscopy, 12 in histopathology and 16 in radiology. The studies were described with a grid of 28 items and evaluated with a quality score (QUAS; maximum, 35) including 22 items. Results The following agreement level was noted: intra-observer > inter-observer > inter-centre. The following signs had good agreement. Endoscopy: size and red signs of oesophageal varices; histopathology: cirrhosis, fibrosis and steatosis; Doppler: mean portal vein and superior mesenteric artery velocities, hepatic artery area and perfusion indexes. Frequent methodological weaknesses were noted. The real agreement (such as the kappa index excluding chance), and the prevalence of signs and biases were rarely assessed. Standardized observations (67% of the studies), blind assessment (48%), simultaneous observations (7%), and the recording technique were not frequently used. The mean QUAS was 13 ± 6 with 17 ± 4 in histopathology versus 11 ± 6 in radiology (P < 0.05). Using multiple regression, four variables independently predicted the QUAS with R2 = 0.77: adapted tests, multiple observations, intra-class correlation coefficient and agreement proportion. Conclusions Methodology was often insufficient. Agreement is often measured under biased conditions. Some areas were not or were rarely studied, e.g., biology and ultrasound. The agreement and QUAS were often poor, suggesting the need for studies with improved observation and methodological quality of agreement.
TermoPL - a Flexible Tool for Terminology Extraction

The purpose of this paper is to introduce the TermoPL tool created to extract terminology from domain corpora in Polish. The program extracts noun phrases, term candidates, with the help of a simple grammar that can be adapted for user’s needs. It applies the C-value method to rank term candidates being either the longest identified nominal phrases or their nested subphrases. The method operates on simplified base forms in order to unify morphological variants of terms and to recognize their contexts. We support the recognition of nested terms by word connection strength which allows us to eliminate truncated phrases from the top part of the term list. The program has an option to convert simplified forms of phrases into correct phrases in the nominal case. TermoPL accepts as input morphologically annotated and disambiguated domain texts and creates a list of terms, the top part of which comprises domain terminology. It can also compare two candidate term lists using three different coefficients showing asymmetry of term occurrences in this data.
Cohomology Theory for Digital Images

In this paper we propose a mathematical framework that can be used for defining cohomology of digital images. We state the Eilenberg-Steenrod axioms and the Universal Coefficient Theorem for this cohomology theory. We show that the Künneth formula doesn’t hold. A cup product is defined and its main properties are proved. 2010 Mathematics Subject Classification. 55N99, 68R99, 68U05, 68U10.