Miracle-dz/UniFAR-FTUs huggingface dataset:
Subacute Toxicity Studies of Ethanol Root Extract Of Mucuna Pruriens on Albino Wistar Rats

Objective: The subacute toxicity of ethanol root extract of Mucuna pruriens was evaluated in albino Wistar rats. Methods: The study was conducted by intraperitoneal administration of the extract at daily doses of 125, 250, 500 and 750 mg/kg body weight to groups of five (5) rats each, for a period of 28 days. Rats in the control group received only 0.5ml of normal saline. Results: Mortality and significant (p<0.05) decrease in percentage gain/loss in body weight were recorded for all the groups treated with 500 and 750mg/kg body weight of the root extract. There was a significant (p<0.05) increase in the activities of serum biomarker enzymes (Aspartate amino transferase, Alanine amino transferase and Alkaline phosphatase) and increased serum concentrations of cholesterol, triglyceride and low density lipoprotein cholesterol (LDL-C) with concomitant decrease in high density lipoprotein cholesterol (HDL-C) concentration of rats treated with 500 and 750 mg/kg body weight of the extract, compared to the control group. There was significant (p<0.05) increase in the serum concentrations of urea and creatinine with decrease serum concentrations of total protein and albumin concentration of rats treated with 250, 500 and 750 mg/kg body weight. Treatment with 125 mg/kg body weight significantly (p<0.05) decreased the serum cholesterol concentration of the rats. No significant (p>0.05) changes were recorded in the serum electrolyte concentrations and hematological parameters of all the treated groups. Histological examination of the kidney, liver and heart revealed tissue damage and infiltrations on the groups treated with 500 and 750 mg/kg body weight of Mucuna pruriens root extract. Conclusions: It could therefore be concluded that the intake of high doses of this extract can cause organ and system damage
Directed polaron propagation in linear polypeptides induced by intramolecular vibrations and external electric pulses 06 / 07 / 2018

We study the propagation of α-helix polarons in a model describing the non-adiabatic interaction between an electron and a lattice of quantum mechanical oscillators at physiological temperature. We show that when excited by a sub-picosecond electric pulse, as induced by experimentally observed sub-picosecond charge separation, the polaron is displaced by up to hundreds of lattice sites before the electron becomes delocalised. We discuss biophysical implications of our results.
INTERNATIONAL TOURISM-ECONOMIC PARAMETERS AND STATUS QUO ENEA CONSTANTA

Rezumat An analysis of the Romanian tourism cannot be obtained without following the development of the tourism indicators at international level. A first image reveals a thriving international tourism with an upward trend. Also, the forecasts regarding tourism, based on the extrapolation of the factors’ influence, anticipate a continuous growth of it. The influence of the international events slows the level of growth of the indicators, but it cannot determine a decrease in them. Tourism is considered, mainly, a form of recreation with other activities and forms of leisure. In terms of tourism, according to the new regulations, it designates "the activities of persons ,during travel and stays, in locations outside of the normal residence for a consecutive period not exceeding one year, with the purpose of leisure, business or other reasons "[1]
A Survey on Trajectory Big Data Processing

Rapid advancements of location-based information provided by publicly available GPS-enabled mobiles devices boost the generation of massive trajectory data. Recently, numerous researchers have addressed many problems regarding trajectory data, which is based on storage and queries processing. Further, a wide spectrum of application domains can benefit from trajectory data mining including trajectory organization as well as queries. Therefore, large-scale trajectory data has received increasing attention in research fields as well as in industry. As the massive trajectory data processing exceeds the power of centralized approaches used previously, in this paper, we survey various existing tools used to process large-scale trajectory data in a distributed way, e.g. MapReduce, Hadoop, and Spark. Furthermore, this paper reviews an extensive collection of existing applications of movement objects, including trajectory data mining and frequent trajectory. We also propose an open interesting research direction, which is challenging and has not been explored up until now, to improve the quality of trajectory query.
Pernot Multi-criteria similarity assessment for CAD assembly models retrieval 1807

The use of Digital Mock-Up (DMU) has become mainstream to support the engineering activities all along the Product Design Process. Over the years, companies generated large databases containing digital models and documents related to their products. For instance, considering complex products, the DMU can be composed of several hundred thousand parts assembled together in assembly trees containing tens of sub-assemblies, and representing several terabytes of data. The ability to retrieve existing models is crucial for the competitiveness of companies, as it can help to leverage existing solutions, results and knowledge associated with previous products. To speed up the access to this large amount of reusable information, CAD models search approaches have been proposed, and notably the so-called content-based search techniques which help designers exploiting the implicit knowledge embedded in the models. As part of a system for the retrieval of CAD assembly models, this paper introduces a set of four measures to evaluate assembly similarities according to multiple criteria. These measures are combined to assess three different levels of similarity (local, partial and global). The local measure only considers the contribution of similar parts, while partial and global measures take also into account the number of similar parts compared to the total number of parts in the query and in the target model. Moreover, an ad-hoc visualization interface has been designed to clearly highlight the different similarities and to allow a fast identification of the target models. The validation of the proposed measures is discussed through several academic and industrial examples run on the developed prototype software.
Partially observed nonzero-sum stochastic differential games with g-expectations

This paper is concerned with a partially observed nonzero-sum stochastic differential game system under g-expectation, where the state is governed by a Itô-Lévy process and the cost functionals are described by g-expectations. Based on Girsanov’s theorem and convex variation techniques, we derive a maximum principle and a verification theorem. An asset-liability management game problem is discussed to illustrate the results.
2 A Random Sample 2 . 1 Simple Inference for a Random

Reproducibility of quantitative results is a theme that calls for probabilistic models and corresponding statistical methods. The simplest model is a random sample of normally distributed observations for both the original and the replication data. It will often lead to the conclusion of a failed reproduction because there is stochastic variation between observation campaigns, or unmodeled correlations lead to optimistic measures of precision. More realistic models include variance components and/or describe correlations in time or space. Since getting the “same circumstances” again, as required for reproducibility, is often not possible or not desirable, we discuss how regression models can help to achieve credibility by what we call a “data challenge” of a model rather than a replication of data. When model development is part of a study, reproducibility is a more delicate problem. More generally, widespread use of exploratory data analysis in some fields leads to unreliable conclusions and to a crisis of trust in published results. The role of models even entails philosophical issues.
17 Restricted Boltzmann Machine Model sf Multiple Local Linear SVM Detectors Scores of Local Detectors Off ‐ line Training On ‐ line Detection

One of the main challenges in pedestrian detection is occlusion. This paper presents a new method for pedestrian classification with partial occlusion handling. The proposed system involves a set of component-based classifiers trained on features derived from non-occluded dataset. The scores of all component classifiers are statistically modeled to estimate the final score of pedestrian. A generative stochastic neural network model namely Restricted Boltzmann Machine (RBM) is learned to estimate the posterior probability of pedestrian given its components scores. The training data used to train RBM model is artificially generated occluded data which simulate real occlusion conditions appeared in pedestrians. Experimental results on real-world dataset, with both partially occluded and non-occluded data shows the effectiveness of the proposed method.
Population Policy as a Means for BioPolitics : The Cases of Romania and China Pelin

After the discovery of “population” in modern society, domination over the body has been enacted by a set of interventions which are called regulatory control, or bio-politics by Michel Foucault. From the eighteenth century onwards, bio-politics has involved any kind of intervention which acts as means for forming the population according to the wills of those with power. This has led to an era of bio-politics in which fertility in particular has become regulated in accordance with political economy. Hence the body, especially the female body, has been reduced to an economic object by detaching her identity, personal aspirations and desires. In turn, sexuality becomes a subject of economic interventions through pronatalist and/or antinatalist politics. In either way, those interventions should be methodologically regarded as instruments of bio-politics. This paper specifically focuses on pronatalist and antinatalist politics as bio-political instruments in the well-known Romanian case and the Chinese case by drawing upon the Foucauldian perspective of bio-politics.
Submitted to the Annals of Statistics BAYESIAN SEMI-PARAMETRIC ESTIMATION OF THE LONG-MEMORY PARAMETER UNDER FEXP-PRIORS : SUPPLEMENTARY MATERIAL

This supplementary material contains technical lemmas and inequalities used in the main text of Bayesian semi-parametric estimation of the long-memory parameter under FEXP-priors. It starts with a series of (in)equalities on integrals (Lemmas 1.1 and 1.2) and a deviation bound for quadratic forms (Lemma 1.3). In Lemmas 2.1-2.6 (section 2) we prove results on the asymptotic behavior of Toeplitz matrices. These results require the Hölder constants of various functions, which are given in section 3. Finally, the proof of Lemma B.2 is given in section 4.
An Investigation and Analysis of the Vestibulo-Ocular Reflex in a An Investigation and Analysis of the Vestibulo-Ocular Reflex in a Vibration Environment Vibration Environment

Helmet Mounted Displays (HMDs) and their integration into military systems have greatly improved. However, previous research has demonstrated degraded visual performance when an HMD user is subject to whole-body, low-frequency vibration. This effect has been attributed to the effect of the Vesitbular-Ocular Reflex as it stabilizes the eye with respect to the external environment, causing eye movement with respect to the HMD. This research sought to understand the VOR as a function of whole-body, low-frequency, z-axis vibration. A human subject experiment was executed to measure the effect of whole-body, low-frequency vibration on eye movements recorded with Electro-oculagraphy (EOG) while performing visual fixation tasks on an HMD. The results indicate that during fixation on a stationary target, the magnitude of VOR-driven eye movement was greatest for a vibration frequency range of 4-6 Hz. The findings are consistent with previous research in visual performance. 1997; Tangorra, et al., 2004). The Tabak study, which involved fixation on a target, found that VOR gain decreased up to 8 Hz, and then increased. The Tangorra study, which involved tracking a moving target, found the VOR gain increased at frequencies greater than 4 Hz. Both studies concluded that the VOR has non-linear dynamics at higher frequencies and suggested the need for further evaluation. These studies did attempt to control the vibration of the head by using a head perturbation system and did not induce whole-body vibration. The present study, conducted at vibration frequencies encountered by rotorcraft and during buffeting, sought to validate these findings and provide a foundation to further research on compensation algorithms.
PEG-4000 Increased the Mating Efficiency of Yeast-Two Hybrid Screening Process using PmF-box 1 as Bait ( PEG-4000

Protein degradation can occur through Ubiquitin 26S-Proteosome System (UPS). The degradation can be mediated by the SCF E3 ubiquitin ligase complex consisting of Skp1, Cullin, and F-box protein as the main components. The F-box protein at the C-terminal domain functions to recognize the targeted protein to be ubiquitinated and degraded via UPS. A stress-responsive F-box gene, PmF-box1 from Persicaria minor was categorized in the F-box containing kelch repeat (FBK) family; a family that specific to plant kingdom. To identify the targeted protein of PmF-box1, yeast-two hybrid system (Y2H) was used. In the Y2H screening process, mating efficiency is very important to fish out the interacting proteins. Therefore, one modification was conducted to increase the mating efficiency. In this screening, PmF-box1 was used as a bait to screen for the Y2H library which was constructed using RNA from plant samples treated with abscisic acid (ABA) and polyethylene glycol (PEG)-8000 and control sample. Autoactivation and toxicity tests of bait were performed before the Y2H screening. Tests on PmF-box1 showed that it is not toxic to the yeast and cannot autoactivate the yeast reporter genes. Mating efficiency was improved from 2.07% to 9.15% after addition of PEG-4000 in the mating culture compared to the original protocol, which it also increased the colony number in the screening step afterward. Additionally, bands of gene with different sizes were observed on electrophoresis gel after colony PCR analysis from the improved technique. Those genes may code for potential interacting proteins that needs further identification and confirmation.
Tourism activities and companies in a sustainable adventure tourism destination: the Azores

The Azores is one of the most sustainable nature-based island destinations in the world. Local tourism activities companies are vital to tourists’ adventure experiences. These businesses’ portfolios were analysed using various editions of the official Tourism Activities Guide . The analysis focused on companies’ products, types of activities, geographical coverage and brands. The generalised profile generated indicates that these firms each operate on only one island, have a small portfolio and are prone to specialise in sea or land activities. Snorkelling and motor boat rides are the most common sea activities, while nature hikes and walks, van tours and cultural tours are the most widely offered land activities. Explicit or indirect references to the Azores and adventure often appear in companies’ brands, which is in line with international trends in adventure tourism. However, company profiles are changing due to the impacts of a new air transport model.
PTC & B Molecular Characterization and Genetic Relationships of Some Stress Tolerant Grape Rootstock Genotypes as Revealed by ISSR and SSR Markers

Grapevine rootstocks are a complex group of plants; most of them are interspecific hybrids evolved using parent genotypes having inherent tolerance to biotic and abiotic stresses. Fifteen species and interspecific hybrids of grape rootstocks along with three Vitis vinifera cultivars from IARI germplasm unit were analyzed with ten ISSR and seven SSR primers combinations. These ISSR produced 69 scorable bands with band size ranged from 200 to 1500 bp, PIC from 0.66 to 0.86 and primer heterozygosity ranged from 0.71 to 0.88. While, SSR primers detected a total of 24 alleles across 15 genotypes with PIC from 0.43 to 0.78 and primer heterozygosity from 0.49 to 0.81. The genetic similarity among the 15 grape genotypes using ISSR and SSR ranged from 0.27 to 1.00 in ISSR and 0.05 to 1.00 in SSR analysis. The genetic similarity matrices using ISSR analysis ranged from 27.0 to 85.0% and SSR 5.0 to 83.0%, respectively. The Vitis species Dogridge and Salt Creek had the highest similarity coefficient of 85% with ISSR analysis, while the interspecific hybrids 1103 Paulsen and 110 Richtier had the maximum similarity coefficient of 83% as identified by SSR analysis. The two marker systems formed two main clusters which were almost similar to that of PCA values. The principal coordinate analysis further helped in depicting the variability among species and hybrids of grape genotypes in three dimensional modes. In case of ISSRs, the first three coordinates accounted 51.92% for the existing variability, while with SSRs the variability accounted is 59.69%. The results revealed that ISSR and SSR markers could be exploited for genetic diversity analysis among the highly heterozygous grape rootstock species and interspecific hybrids. *Author for correspondence: , . 1Horticulture Science, Indian Council of Agricultural Research, New Delhi 110012, India. 2ICARNational Bureau of Plant Genetic Resources, Pusa Campus, New Delhi 110 012, India. 3Division of Genetics, ICAR-Indian Agricultural Research Institute, New Delhi 110 012, India.
Síndrome de Burnout en Cuidadores de Pacientes con Discapacidad Infan l Burnout Syndrome in Caregivers of Pa ents with Childhood Disability

The aim of this study was to value the prevalence of burnout syndrome in caregivers of pa ents with disabili es from Arequipa City. The sample was conformed by 45 caregivers (91.42% female and 8.8% male) with and average age of 30.26 years old. We applied the Burnout Maslach Inventory, which has 22 items and three dimensions: exhaus on, cynicism and inefficacy. Its reliability is adequate for health personnel like this case (α= 0.721). The caregivers of pa ents with disability are women and rela ves of the people who are under their responsibility. They also have high levels of exhaus on and inefficacy. Around 97.6% of people sampled have moderate levels of burnout syndrome. Moreover, women present major levels of cynicism than men, and while family caregivers have mayor levels of exhaus on, professional caregivers reach severe levels of inefficacy. We conclude that caregivers of people with disabili es have high risk of having burnout syndrome, which is characterized by severe levels of exhaus on and inefficacy. KEYWORDS
Effects of water absorbing soil amendments on potato growth and soil chemical properties in a semi-arid region

A field experiment was conducted in 2010-2012 in a semi-arid region in northern China to study the effects of synthetic and natural water absorbing soil amendments on potato plant growth and soil chemical properties. A no amendment control, two synthetic water absorbing amendments (potassium polyacrylate-PAA, polyacrylamide-PAM) and a natural amendment (humic acid-HA), were applied annually as single amendments, and in combination (natural plus synthetic). Soil amendment showed a significant (P≤0.05) effect on plant height, stem diameter and leaf area index in the potato growing period in all three years, and improved these plant growth parameters respectively by 0.49%-36.90%, 2.59%-21.12% and 1.85%-37.57%. Soil amendments showed a significant (P≤0.05) effect on soil chemical parameters in different soil layers in all three years, and improved soil organic matter, soil available nitrogen, phosphorus and potassium respectively by 1.03%-11.20%, 0.82%-13.99%, 1.24%-16.61% and 4.50%-22.20%. Soil amendments significantly (P≤0.05) affected fresh tuber yields in the <75 g and 75-150 g size categories; <75 g was decreased by 2.7% to 48.3% (except in 2010) and 75-150 g was increased by 3.5% to 47.6% (except under 45 kg ha PAA in 2011). The accumulative effect on soil chemical indicators increased over time with repeated annual application of the amendments in the same field, and the effect of soil amendment on soil chemical indicators was weaken with the increasing soil depth. The PAM+HA amendment always had the greatest effect on plant morphological parameters and soil chemical properties and thus merits further research.
nemployment is associated with lower cortisol awakening and lunted dehydroepiandrosterone responses

Previous research has investigated the endocrinological consequences of unemployment as a likely pathway behind chronic stress and negative health outcomes. Despite these early attempts at delineating the neuroendocrine consequences of the chronic stress experienced by the unemployed, identifying a consistent and stable effect has remained elusive. Here we sought to strengthen existing knowledge into the effect of the stress of employment status on cortisol by improving on the methodological weaknesses of earlier studies and extend this line of enquiry by measuring the steroid hormone Dehydroepiandrosterone-Sulfate (DHEAS). Saliva samples were collected from unemployed and employed participants at four time points across two days. As expected, unemployed people reported higher stress, lower social support and lower self-esteem. Unexpectedly, the unemployed showed lower overall cortisol output, a likely consequence of a higher cortisol awakening response (CAR) in the employed. However, they also had a higher DHEA output across the day, albeit the diurnal pattern across the day was more dysregulated compared to that seen in those employed with a blunted response evident in the evening; the cortisol:DHEAS ratio was also lower in the unemployed group. Further, these hormone differences were correlated with self-esteem and stress. Taken together these results suggest that the relationship between employment status and endocrine responses is far more complicated than previously thought. We have shown for the first time that unemployed people have a lower CAR, but also show a blunted DHEA response relative to those employed and we suggest that this may be a feature of chronic stress exposure or perhaps dependent on the prevailing socio-economic context. © 2016 Elsevier Ltd. All rights reserved.