Miracle-dz/UniFAR-FTUs huggingface dataset:
Serum Lipid Profile, Serum Magnesium and Fasting Serum Glucose in Newly Diagnosed Type 2 Diabetic Subjects

Type 2 diabetes is considered as a major health burden due to its rising prevalence and disabling, life threatening complications. Dyslipidemia, often coexisting with T2DM as a feature of insulin resistance, is hypothesized to be linked with altered magnesium homeostasis. This study was designed to evaluate the serum magnesium levels and its influence on serum lipids in type 2 diabetics. Lipid profile, serum magnesium (Mg) and fasting serum glucose (FSG) were measured in 30 newly diagnosed normotensive type 2 diabetic patients chosen as cases (Group II) just before introducing any treatment, and was compared with that of 30 healthy controls (Group I). The serum magnesium was found to be significantly lower (p<0.001) and LDL-c was found to be significantly higher (p<0.01) in cases. The correlation analysis revealed a significant negative association of FSG to serum magnesium (r= -0.720), total cholesterol (r=-0.483) and a positive correlation to HDL-c (r=-0.440). However, serum magnesium showed a significant positive relation only with serum HDL-c (r =0.372, p<0.05). Serum magnesium and lipid fractions showed wide range of variation within the normal reference ranges in the newly diagnosed T2D subjects. Further large scale studies are needed to elucidate the association of serum magnesium with lipid profile changes. Estimation of serum magnesium level may prove useful in T2DM with normal or abnormal lipid levels or in those who are prone to develop dyslipidemia or certain complications associated with dyslipidemia. DOI: http://dx.doi. org/10.3329/bjmb.v7i1. 18572 Bangladesh J Med Biochem 2014; 7(1): 4-8
Visual and 3D Mapping for Steel Bridge Inspection Using a Climbing Robot

There are over six hundred thousand bridges in the U.S. which require great amount of human effort along with expensive and specialized equipment for maintenance. Current bridge inspections are manually performed by inspectors which are inefficient and unsafe. This paper presents visual and three dimensional (3D) structure inspection for steel bridges and steel structures using the developed climbing robot. The robot can move freely on steel surface, carry several sensors, and collect data then send to the ground station for real-time monitoring as well as further processing. Steel surface image stitching and 3D map building are conducted to provide a current condition of the structure.
MEDICAL AND FUNCTIONAL STATUS OF ADULTS WTH CEREBRAL PALSY

One hundred and one adults (19 to 74 years of age) with cerebral palsy were interviewed and examined. There were 52 subjects with dyskinesia, 28 with spastic quadriparesis, 11 with spastic diplegia, and 10 with spastic hemiplegia. Neuromuscular dysfunction was mild in two cases, moderate in 72 and severe in 27. 76 per cent of the subjects had multiple musculoskeletal problems. In 63 per cent, these occurred under 50 years of age, suggesting that abnormal biomechanical forces and immobility had led to excessive physical stress and strain, overuse syndromes, and possibly early joint degeneration. A number of the patients had urinary complaints due to difficulties with toilet accessibility and possible neurogenic bladder. General health care seemed satisfactory for acute illnesses, but preventive health care was almost totally lacking. Treatment for the musuculoskeletal system and availability of adaptive devices were less adequte than for children with cerebral palsy.
Cognitive-Behavioral Therapy and Psychosocial Factors in Low Back Pain: Directions for the Future

Study Design. An amalgamated review of the current state of knowledge about psychosocial factors in low back pain (LBP), as presented at the plenary session at the Fourth International Forum on LBP Research in Primary Care (March 16–18, 2000, Israel). Objectives. To outline evidence-based theories that have lead to the identification of yellow flags (psychosocial risk factors for developing long-term disability) for nonspecific LBP. To discuss the role of clinicians in primary care in detecting and addressing these psychosocial factors and to outline future directions for research to clarify this role. Summary of Background Data. It is widely accepted that psychological and social factors play an important role in LBP; however, it is currently unclear which specific factors merit intervention to reduce the burden of disease. Method. The review is an integration based on the plenary session presented at the Fourth International Forum on LBP Research in Primary Care. The presentations included original research studies, a systematic review, and theoretical descriptions of models of risk and treatment. Results. There is good evidence to support the role of psychological risk factors at early stages of LBP in the development of long-term disability. There are evidence-based theories and models that provide directions for future interventions. Conclusion. In the treatment of psychological factors, the role of clinicians in primary care remains unclear. Further evidence is needed to identify specific psychological risk factors, primary care tools for their identification need developing, and interventions at different stages of LBP by different professionals need to be tested.
AT 1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction

Anni Eskild-Jensen, Lene Fogt Paulsen, Lise Wogensen, Ping Olesen, Lea Pedersen, Jørgen Frøkiær, and Jens Randel Nyengaard Department of Clinical Physiology and Nuclear Medicine and Research Laboratory of Biochemical Pathology, Aarhus University Hospital, and Stereology and Electron Microscopy Research Laboratory and MIND Center, The Water and Salt Research Center, and Institute of Clinical Medicine, University of Aarhus, DK-8000 Aarhus C, Denmark
The word order myth

ABSTRACT The purpose of this research was to investigate the function of word order, inflections and discourse context in the sentence comprehension process. Ten 2; 6 and ten 3; 6 Polish children acted out sentences with toys. The target sentences were either inflected or uninflected, and given inflectional information sentences were ordered SVO or OVS. Context sentences established given information which was in initial or final position in the target sentences. When inflectional information was available, all the children used it effectively with very little interference from OVS and new–given arrangements. In spite of the fact that word order distributes given and new information in adult Polish, children could utilize word order to recover semantic functions with uninflected sentence problems.
Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice

Background: Planar cell polarity (PCP) signaling regulates the coordinated polarization of cells and is required for the normal development and function of many tissues. Previous studies have identified conserved PCP genes, such as Van Gogh‐like 2 (Vangl2) and Prickle (Pk), in the regulation of coordinated orientation of inner ear hair cells and female reproductive tract development. Testin shares a PET‐LIM homology with Pk. It is not clear whether Testin acts in PCP processes in mammals. Results: We identified Testin as a Vangl2‐interacting protein through a 2‐hybrid screen with a cochlea cDNA library. Testin is enriched to cell–cell boundaries in the presence of Vangl2 in cultured cells. Genetic inactivation of Testin leads to abnormal hair cell orientation in the vestibule and cellular patterning defects in the cochlea. In addition, Testin genetically interacts with Vangl2 to regulate hair cell orientation in the cochlea and the opening of the vaginal tract. Conclusions: Our findings suggested Testin as a gene involved in coordinated hair cell orientation in the inner ear and in female reproductive tract development. Furthermore, its genetic interaction with Vangl2 implicated it as a potential molecular link, responsible for mediating the role of Vangl2‐containing membranous PCP complexes in directing morphologic polarization. Developmental Dynamics 242:1454–1465, 2013. © 2013 Wiley Periodicals, Inc.
Segmentation et regroupement en locuteurs pour la parole conversationnelle

Dans le contexte du discours conversationnel, nous presentons un systeme hybride de segmentation et regroupement en locuteurs utilisant la combinaison des systemes du LIUM et de IRIT. Il contient une premiere etape de detection de la parole suivie d'une segmentation en locuteurs. Ensuite, nous appliquons un regroupement en locuteurs en deux etapes: un premier regroupement base sur BIC (Bayesian Information Criterion) est suivi par un regroupement base sur le CLR (cross likelihood ratio). De plus, nous apportons quelques ameliorations en optimisant les seuils de regroupement et en purifiant le regroupement BIC a l'aide de la F0. Les resultats montrent que ce systeme hybride est approprie d'une part pour le corpus traditionnel comme ESTER et d'autre part pour les donnees conversationnelles telles qu'utilisees dans le projet EPAC.
Three-Dimensional Positioning for LTE Systems

In the Third-Generation Partnership Project (3GPP) Long-Term Evolution (LTE) specifications, several 2-D positioning methods have been proposed to support location-based services (LBSs). It has been shown that the observed time difference of arrival (OTDOA) method provides the best result. With the advent of the fifth-generation cellular systems, 3-D beamforming will be introduced, and 2-D positioning may not be sufficient for future applications. Although the conventional OTDOA method can be used in 3-D positioning, it requires more base stations (BSs) in cooperation and often performs poorly in typical cellular network geometry. In this paper, we propose a novel OTDOA-based method to solve the problems. First, we exploit the sparsity of the wireless channel and propose to use a compressive-sampling-based channel estimation method, which greatly enhances the precision of time-of-arrival (TOA) estimation. Then, we propose a transmit beamforming scheme such that the elevation angle of departure (AOD) can be accurately estimated. Finally, we combine the estimated TOAs and the AOD in the OTDOA scheme to conduct 3-D positioning. With the proposed scheme, the number of BSs required for 3-D positioning remains the same as that of 2-D, and the positioning accuracy greatly outperforms that of the conventional OTDOA method. Simulations show that 90% of the position error can be less than 7 m.
Radial variation in sap flow in five laurel forest tree species in Tenerife, Canary Islands.

Variations in radial patterns of xylem water content and sap flow rate were measured in five laurel forest tree species (Laurus azorica (Seub.) Franco, Persea indica (L.) Spreng. , Myrica faya Ait. , Erica arborea L. and Ilex perado Ait. ssp. platyphylla (Webb & Berth.) Tutin) growing in an experimental plot at Agua García, Tenerife, Canary Islands. Measurements were performed around midday during warm and sunny days by the heat field deformation method. In all species, water content was almost constant (around 35% by volume) over the whole xylem cross-sectional area. There were no differences in wood color over the whole cross-sectional area of the stem in most species with the exception of E. arborea, whose wood became darker in the inner layers. Radial patterns of sap flow were highly variable and did not show clear relationships with tree diameter or species. Sap flow occurred over the whole xylem cross-sectional area in some species, whereas it was limited to the outer xylem layers in others. Sap flow rate was either similar along the xylem radius or exhibited a peak in the outer part of the xylem area. Low sap flow rates with little variation in radial pattern were typical for shaded suppressed trees, whereas dominant trees exhibited high sap flow rates with a peak in the radial pattern. Stem damage resulted in a significant decrease in sap flow rate in the outer xylem layers. The outer xylem is more important for whole tree water supply than the inner xylem because of its larger size. We conclude that measurement of radial flow pattern provides a reliable method of integrating sap flow from individual measuring points to the whole tree.
Structural determinants of DNA-binding specificity by steroid receptors.

Specific DNA binding by transcription factors constitutes an important part of the specificity of gene regulation. Many transcription factors are members of large families of proteins that bind to similar, but distinct, DNA sequences. The individual proteins must be able to distinguish between the closely related DNA sequences. The nuclear receptors form a family of transcription factors that are activated by steroid hormones, thyroid hormone, retinoids, and vitamin D, (for reviews see Refs. l-3). Many orphan nuclear receptors have been identified for which no ligands have been found as yet. Upon ligand binding the receptors interact with specific DNA sequences near the regulated gene, called response elements, and activate or repress gene transcription. The members of the nuclear receptor family regulate different aspects of development, differentiation, growth, homeostasis, and metabolism in the cell. The specific functions of the members of the family depend upon the genes that they regulate. Part of the specificity of gene regulation within the family is due to the recognition of the response elements with which the nuclear receptors interact. The response elements are composed of 6 base pair half-site sequences that are organized as palindromic or direct repeats. The nuclear receptors bind mainly as dimers to the response element, and each monomer interacts with a half-site sequence within the response element. The nuclear receptors can be divided into two classes depending upon their DNA recognition. Most members of the nuclear receptor family, including the estrogen receptor (ER), recognize the same DNA half-site sequence, and the specificity within this group is determined by recognition of different organizations of the half-sites. The glucocorticoid receptor (GR) group, which also in-
THE CERVICAL SPINE: TRANSFORMATION OF THE NORMAL LORDOTIC PATTERN INTO A LINEAR PATTERN IN THE NEUTRAL POSTURE.

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Mo/spl uml/ssbauer studies of nano-size controlled iron oxide for biomedical applications

We present the magnetic properties and the material characteristics of magnetite (Fe/sub 3/O/sub 4/), which was successfully prepared by using the reaction of iron(III) acetylacetonate [Fe(acac)/sub 3/] with surfactants at high temperature (so called by "high temperature decomposition method"). According to the results of high resolution transmission electron microscopy (HRTEM) analysis, the prepared iron oxide particles had the average particle sizes between 4 and 6 nm and very uniform size distributions. The crystal structure analyzed by using both XRD and Mo/spl uml/ssbauer spectra confirmed that the prepared iron oxide nanoparticles only have single magnetite (Fe/sub 3/O/sub 4/) crystal phase. The typical superparamagnetic behaviors were observed from the prepared iron-oxide nanoparticles. In addition, they showed the saturation magnetization, M/sub S/ of 59.5 emu/g for 4 nm, and of 59.7 emu/g for 6 nm, respectively at room temperature under the externally applied magnetic field of 10 kOe. The measured Mo/spl uml/ssbauer spectrum at 4.2 K was fitted using two magnetic components: (1) hyperfine fields H/sub hf/=514 and 492 kOe, (2) isomer shifts /spl delta/=0.35 and 0.73 mm/s. The fitted data apparently verified that the prepared iron oxide samples only have pure magnetite ([Fe/sup 3+/]/sub A/ [Fe/sup 2+/Fe/sup 3+/]/sub B/O/sub 4/).
Single-Layer Circularly Polarized Antenna With Fan-Beam Endfire Radiation

A single-layer single-fed endfire antenna with circularly polarized radiation has been designed and evaluated. The concept is the superposition of two closely spaced complementary dipoles. In terms of implementations, a shorted parallel-plate cavity serves as the magnetic dipole, while double-side-printed conductor arms act as the electric dipole. To satisfy the required magnitude/phase relationship between two dipoles, a T-shaped double side slot-coupled line and a meandered double-side parallel strip line are introduced. With analyses of equivalent models, the operation mechanism and design guidelines can be obtained. Taking 5.8-GHz ISM band (5.725–5.875 GHz) for example, the measured results show that the designed antenna has an impedance bandwidth <inline-formula><tex-math notation="LaTeX"> $({| {S_{11}} | < - 10\; {\text{ dB}}})$</tex-math></inline-formula> from 5.7 to 5.9 GHz (3.5%) and a 3-dB axial-ratio (AR) bandwidth from 5.65 to 5.9 GHz (4.3%). The effective beamwidth in the azimuth/elevation plane is 85°/168° at 5.8 GHz.
Magnetism of Chromia from First-Principles Calculations

The electronic structure and magnetism of chromia (corundum-type ${\text{Cr}}_{2}{\text{O}}_{3}$) are studied using full-potential first-principles calculations. The electronic correlations are included within the $\text{LSDA}+U$ method. The energies of different magnetic configurations are very well fitted by the Heisenberg Hamiltonian with strong exchange interaction with two nearest neighbors and additional weak interaction up to the fifth neighbor shell. These energies are insensitive to the position of the oxygen states, indicating that magnetism in ${\text{Cr}}_{2}{\text{O}}_{3}$ is dominated by direct exchange. The N\'eel temperature is calculated using the pair-cluster approximation for localized quantum spins of magnitude 3/2. Very good agreement with experiment is found for all properties including the equilibrium volume, spectral density, local magnetic moment, band gap, and the N\'eel temperature for the values of $U$ and $J$ that are close to those obtained within the constrained occupation method. The band gap is of the Mott-Hubbard type.
Genetic diversity of a clonal angiosperm near its range limit: the case of Cymodocea nodosa at the Canary Islands

The seagrass Cymodocea nodosa forms a unique community in the Canary Islands, where it is classified as an endangered species. Biogeographic theory predicts that clonal species on islands near their distributional limits might show lower proportions of sexual (versus clonal) repro- duction, lower genetic diversity, and higher differentiation. We addressed these hypotheses by comparing the genetic structure of C. nodosa from 10 meadows in the 4 main Canary Islands with 2 Iberian sites (Atlantic and Mediterranean) using microsatellites. A resampling method was proposed to standardize, among samples, genetic variability statistics estimating genotypic richness (R) and allelic richness (Â). A high degree of genotypic richness at the Canary Islands (R = 0.30 - 0.94, mean = 0.67) relative to Iberian sites revealed that C. nodosa performs effective sexual reproduction here. In contrast, lower Â suggested a founder effect during the colonization of the archipelago, and similar allelic composition across all islands indicated colonization from a single source. A hotspot of genetic diversity was observed in El Medano (Tenerife), probably associated with lower drift in this meadow, the largest of the archipelago. Predominant north-south surface currents and a greater dis- tance to the mainland could explain lower allelic richness of 2 northwestern sites on different islands and greater similarity between them. All meadows were differentiated from each other and there was no correlation between genetic and geographic distances. This non-equilibrium migration-mutation system was therefore mostly influenced by diversity resulting from genetic drift, and less by the homogenizing effects of gene flow.
Mechanisms of Endotoxin Tolerance in Human Intestinal Microvascular Endothelial Cells 1

Lipopolysaccharide (endotoxin) tolerance is well described in monocytes and macrophages, but is less well characterized in endothelial cells. Because intestinal microvascular endothelial cells exhibit a strong immune response to LPS challenge and play a critical regulatory role in gut inflammation, we sought to characterize the activation response of these cells to repeated LPS exposure. Primary cultures of human intestinal microvascular endothelial cells (HIMEC) were stimulated with LPS over 6–60 h and activation was assessed using U937 leukocyte adhesion, expression of E-selectin, ICAM-1, VCAM-1, IL-6, IL-8, manganese superoxide dismutase, HLA-DR, and CD86. Effect of repeat LPS stimulation on HIMEC NF-κB and mitogen-activated protein kinase (MAPK) activation, generation of superoxide anion, and Toll-like receptor 4 expression was characterized. LPS pretreatment of HIMEC for 24–48 h significantly decreased leukocyte adhesion after subsequent LPS stimulation. LPS pretreatment inhibited expression of E-selectin, VCAM-1, IL-6, and CD86, while ICAM-1, IL-8, and HLA-DR were not altered. Manganese superoxide dismutase expression increased with repeated LPS stimulation, with a reduction in intracellular superoxide. NF-κB activation was transiently inhibited by LPS pretreatment for 6 h, but not at later time points. In contrast, p44/42 MAPK, p38 MAPK, and c-Jun N-terminal kinase activation demonstrated inhibition by LPS pretreatment 24 or 48 h prior. Toll-like receptor 4 expression on HIMEC was not altered by LPS. HIMEC exhibit endotoxin tolerance after repeat LPS exposure in vitro, characterized by diminished activation and intracellular superoxide anion concentration, and reduced leukocyte adhesion. HIMEC possess specific mechanisms of immunoregulatory hyporesponsiveness to repeated LPS exposure.
Skin reaction and recovery: a repeated sodium lauryl sulphate patch test vs. a 24‐h patch test and tape stripping

Background Little is known of the predictive value of methods to test an individual's susceptibility to acquiring occupational contact dermatitis. Recently, the recovery rate after induced irritation was suggested for this purpose. Although it is likely that repeated exposure to sodium lauryl sulphate (SLS) is preferable to a single application, there is little evidence to support this idea. Similarly, little is known about whether the outcome of a repeated SLS test can be predicted by a brief test.