Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimal Design and Energy Efficient Binary Resource Allocation of Interference-Limited Cellular Relay-Aided Systems With Consideration of Queue Stability

The topic of subcarrier and power allocation in the downlink of an orthogonal frequency division multiple access decode-and-forward relaying system is presented with the objective of encompassing system stability and interference limitations in one inclusive problem. The introduced model is designed to maximize the overall throughput of the cell-edge users that are served by relay stations. We analyze the stability requirement of buffers in the base station and the corresponding relay stations, and define the rate constraints in order to guarantee queue stability without requiring a priori knowledge of arrival traffic’s statistics. The explained model results in a nonconvex optimization problem, and therefore, we employ a time-shared technique to achieve the closed form solution, which is only applicable when subcarriers can be shared by the users during one time-slot. In the case where the subcarriers are not allowed to be time-shared, we introduce a computationally efficient optimal binary subcarrier and power allocation method, in addition to a power conservative allocation mechanism. Using geometric-programming and monomial approximation techniques, we show that the proposed conservative approach, although nonconvex, can be solved in polynomial time. We also study the impact of adjustable time-slot division and interference-tolerance parameters on improving system performance. The extensive simulation results demonstrate the success of the proposed methods in terms of stabilizing the queues, improving the throughput by 30% and energy efficiency gain by 90%, in comparison with the existing similar models in the literature.
THE CHARLES PROCEDURE FOR PRIMARY LYMPHEDEMA: Long‐Term Clinical Results

The best treatment for primary lymphedema has been a controversial point, because of the lack of clinical documentation of really long-term successful results after any therapy. We report the long-term results in 10 patients (12 extremities) after the Charles procedure. These patients were evaluated at an average period of 10 1/2 years following the surgery (4 of these extremities were examined 20 or more years following the surgery). All of them demonstrated excellent functional results; none demonstrated a recurrence of the lymphedema. We consider the Charles procedure to be the operation of choice in patients with primary lymphedema which is not responsive to conservative therapy.
Sexual function of premature ejaculation patients assayed with Chinese Index of Premature Ejaculation.

AIM To assess the psychometric properties of the Chinese Index of Premature Ejaculation (CIPE). METHODS The sexual function of 167 patients with and 114 normal controls without premature ejaculation (PE) were evaluated with CIPE. All subjects were married and had regular sexual activity. The CIPE has 10 questions, focusing on libido, erectile function, ejaculatory latency, sexual satisfaction and difficulty in delaying ejaculation, self-confidence and depression. Each question was responded to on a 5 point Likert-type scale. The individual question score and the total scale score were analyzed between the two groups. RESULTS There were no significant differences between the age, duration of marriage and educational level (P> 0.05) of patients with and without PE and normal controls. The mean latency of patients with PE and normal controls were 1.6 +/- 1.2 and 10.2 +/- 9.5 minutes, respectively. Significant differences between patients with (26.7 +/- 4.6) PE and normal controls (41.9 +/- 4.0) were observed on the total score of CIPE (P< 0.01). Using binary logistic regression analysis, PE was significantly related to five questions of the original measure. They are the so-called the CIPE-5 and include: ejaculatory latency, sexual satisfaction of patients and sexual partner, difficulty in delaying ejaculation, anxiety and depression. Receiver Operating Characteristic (ROC) curve analysis of CIPE-5 questionnaire indicated that the sensitivity and specificity of CIPE were 97.60 % and 94.74 %, respectively. Employing the total score of CIPE-5, patients with PE could be divided into three groups: mild (>15 point) 19.8 %, moderate (10-14 point) 62.8 % and severe (< 9 point) 16.7 %. CONCLUSION The CIPE-5 is a useful method for the evaluation of sexual function of patients with PE and can be used as a clinical endpoint for clinical trials studying the efficacy of pharmacological intervention.
Robust H∞ filtering with stability degree constraint of a class of nonlinear discrete time stochastic systems

This paper deals with the robust H∞ filtering problem for a class of nonlinear discrete time stochastic systems. The system involves system noise, measurement output noise, nonlinear disturbance signal, and external perturbation. The aim of this paper is to design a robust H∞ filter such that the filtering error system is robustly exponentially stable with a given decay rate, and a prescribed H∞ disturbance attenuation level is guaranteed. An illustrative numerical example is provided to demonstrate the effectiveness of the proposed method.
Immunoreactivities of polyclonal and monoclonal anti‐T and anti‐Tn antibodies with human carcinoma cells, grown in vitro and in a xenograft model

Human polyclonal, monospecific anti‐T and ‐Tn antibodies were found to be reactive in ELISA tests with human ovarian (IGROV‐1, OVCAR‐3 and SKOV‐3), breast (SKBr‐3 and T47D)‐ and oral (KB)‐carcinoma cell lines, but less so or non‐reactive with normal epithelia and fibroblasts. The direct binding radioimmunoassay, using 125I‐labeled human antibodies, to the IGROV‐1 cancer cells was inhibited by homologous unlabeled antibodies of the same concentration, but not by the respective immunodominant haptenic monosaccharides (Gal for T and GalNAc for Tn). Rodent ascitic monoclonal anti‐T (Ca3114 and Ca3741) and anti‐Tn (Ca3250, Ca3268 and Ca3638) antibodies were also reactive with the ovarian‐ and breast‐cancer cells, as measured by FACS and ELISA tests, but to a lower extent than the polyclonal human antibodies. Both the monoclonal anti‐T (Ca3741) and anti‐Tn (Ca3250 and Ca3638) antibody‐binding reactivities were significantly inhibited by the haptenic free monosaccharides. Addition of the above MAbs to IGROV‐1 ovarian‐cancer or T47D breast‐cancer cells cultured in vitro resulted in significant cytological change and inhibition of the viability of the tumor cells, but not of normal epithelial breast cells. This effect on viability was shown to be complement‐independent, yet it was profoundly influenced by the concentration of the serum added to the assay medium. In vivo biodistribution of the anti‐T (Ca3114) and anti‐Tn (Ca3638) MAbs administered i.p. to athymic IGROV‐1 tumor‐bearing CD1 female nude mice revealed higher 125I‐labeled antibody accumulation in the tumor xenografts and in their lung tissues, as compared with other organs of the same mice tested. The above results thus suggest the feasibility of utilizing these antibodies in immunotherapy and drug targeting. Int. J. Cancer 72:119–127, 1997. © 1997 Wiley‐Liss Inc.
The Anonymisation Decision-Making Framework

This book has been developed to address a need for a practical guide to anonymisation that gives more operational advice than the ICO’sAnonymisation Code of Practice, whilst being less technical and forbidding than the statistics and computer science literature. The book may be of interest to an anonymisation specialist who would appreciate a fresh, integrated perspective on the topic. However, it is primarily intended for those who have data that they need to anonymise with confidence, usually in order to share it. Our aim is that you should finish the book with a practical understanding of anonymisation and an idea about how to utilise it to advance your business or organisational goals.
Dams, indigenous peoples and ethnic minorities

A partir d'une analyse detaillee des sources documentaires disponibles, de plusieures enquetes directes aupres des differents acteurs concernes, et des resultats de la reunion consultative Barrages, peuples autochtones et minorites ethniques organisee par la Commission Mondiale sur les Barrages (Geneve, 31 juillet-1 aout 1999), l'A. propose une evaluation de l'impact (positif ou negatif) de la construction de barrages pour les peuples indigenes et les minorites ethniques. Une premiere partie examine la problematique generale de la place des peuples autochtones et des minorites ethniques dans les politiques de developpement national : droit foncier et deplacement de population, cadres juridiques internationaux et autodetermination, modalites de consultation/participation. La deuxieme partie examine les consequences socioculturelles de la construction de barrages de grande envergure et les causes de leur impact negatif. La troisieme partie evalue le role des differents acteurs impliques (communautes locales, ONG, organisations internationales, gouvernements, secteur prive) pour l'elaboration de criteres d'une meilleure pratique. En conclusion, l'A. propose des recommandations precises susceptibles de contrecarrer l'impact ethnocidaire des barrages.
Association between p53 overexpression, cell proliferation, tumor necrosis and extent of apoptosis in operated pancreatic adenocarcinoma

In this study we investigated the immunohistochemical expression of the p53 protein in 44 ductal pancreatic adenocarcinomas and its relation to cell proliferation, apoptosis and necrosis, three factors affecting tumor growth. The results were evaluated against survival and other clinical parameters of the patients. p53‐positivity was found in 18/44 (41%) of the tumors. A positive p53 status was significantly associated with a high extent of necrosis (≥10% of tumor tissue) (p=0.04, Fisher's exact test), with a high immunohistochemical expression of PCNA (p=0.04, Fisher's exact test) and with a high mitotic count (p=0.05, two‐tailed t test). No statistically significant association was found between p53‐positivity and high or low extent of apoptosis as evaluated by in situ labeling of the 3′‐ends of the DNA fragments (p=0.34, Fisher's exact test). Patient survival was not associated with the p53 expression of the tumors or separately with tumor cell proliferation, apoptosis or necrosis. The results suggest that an altered p53 function, as reflected by p53 overexpression, affects tumor growth by promoting cell proliferation and necrosis, but does not show a significant association with the extent of apoptosis in operated pancreatic adenocarcinoma.
Evaluation of the effects of galbanic acid from Ferula szowitsiana and conferol from F. badrakema, as modulators of multi-drug resistance in clinical isolates of Escherichia coli and Staphylococcus aureus

Galbanic acid, a sesquiterpene coumarin from Ferula szowitsiana, and conferol, another sesquiterpene coumarin from F. badrakema, were evaluated for their effects on the reversal of multi-drug resistance in clinical isolates of Staphylococcus aureus and Escherichia coli, respectively. Neither galbanic acid (up to 1000 μg/ml) nor conferol (up to 400 μg/ml) by itself shows any antibacterial activities against tested strains. The minimum inhibitory concentrations (MICs) of ciprofloxacin and tetracycline were determined using macrodilution technique in the presence and absence of sub-inhibitory concentrations of galbanic acid (31.25-1000 μg/ml) or conferol (50-400 μg/ml), however they caused no change in MICs of the antibiotics. Galbanic acid did not show any inhibitory effect on efflux phenomenon of E. coli. This can be related to the outer membrane of gram-negative bacteria which is impermeable to lipophilic compounds or another mechanism rather than efflux responsible for resistance in tested E. coli strains. An inhibitory effect of conferol on the efflux was compared with verapamil as a positive control. Because efflux is the only known mechanism of resistance to ethidium bromide (model efflux substrate) and verapamil reduced MIC of ethidium bromide, efflux mechanism can be considered as one of the resistance mechanisms in tested S. aureus strains. Conferol, however, did not enhance the antibiotic efficacy mediated by inhibiting efflux pumps in bacteria.
Torque ripple minimization technique in fractional-slot PM brushless machines

This paper presents a technique to reduce torque ripple in a fractional-slot PM brushless machine. A 12-slot/10-pole machine equipped with various stators design is the subject of investigation. A better torque performance at rated condition is desirable when additional permanent magnets are inserted on the stator part. The design optimization process on motor topology is performed in order to obtain the best torque performance. It is shown that significant reduction of torque ripple is achieved without losing the desired average torque. The influences of the proposed stator design on the back-EMF, output torque and cogging torque are analysed and compared with the initial machine design.
The Tolerable Cost of European Union Regulation: Leaving the EU and the Market for Politically Convenient Facts

Abstract European Union (EU) law-making has played a key role in promoting social equity in the UK through safer working conditions, enhanced rights for workers, and by reducing environmental pollution. Concerns over its effect on business competitiveness have long been a major driver of Euroscepticism, underpinning criticism of the EU by influential opinion formers within British conservatism. The Leave Campaign argued that EU laws damage the UK economy by imposing unnecessary costs on British business, claiming that EU regulations cost the UK economy £33.3 billion per year. This paper examines the reliability of, and assumptions that underpin, aggregated estimates of the costs and benefits of EU-derived regulation, and considers how the economisation of public policy influences understanding of the social value of regulation. It brings together the findings of studies that have evaluated the accuracy of the estimated costs and benefits in formal impact assessments and analyses impact assessments of EU-derived policy instruments aimed at regulating working conditions. Our findings suggest that aggregated estimates represent poor guides to understanding the social costs and benefits of social regulation and highlight the value of discarding impact assessment estimates of costs and benefits in the context of efforts to shape social policy post-Brexit.
Molecular Genetic Evidence for Subtypes of Oligoastrocytomas

The histogenesis of oligoastrocytomas remains controversial, with some data arguing similarity of oligoastrocytomas to astrocytic tumors, and other data suggesting closer relationships with oligodendroglial neoplasms. Since the molecular genetic changes in astrocytomas differ from those of oligodendrogliomas, we characterized 120 astrocytic and oligodendroglial tumors, including 38 oligoastrocytomas, for genetic alterations that occur disproportionately between astrocytomas and oligodendrogliomas, i.e. TP53 gene mutations and allelic loss of chromosomes 1p, 17p and 19q. As previously reported, TP53 mutations were common in astrocytic gliomas, occurring in approximately half of WHO grade II and III astrocytomas, but in only 5% of WHO grades II and III oligodendrogliomas. Allelic losses of chromosomes 1p and 19q. however, were common in oligodendrogliomas (41% and 63%), but less frequent in astrocytomas (9% and 35%). Oligoastrocytomas showed TP53 mutations in 12/38 (32%) cases and allelic losses of chromosomes 1p and 19q in 52% and 70%, respectively. Most importantly, TP53 mutations and allelic losses on chromosomes 1p and 19q were inversely correlated in oligoastrocytomas (p < 0.011 and p < 0.019). These data suggest the existence of two genetic subsets of oligoastrocytomas, one genetically related to astrocytomas and the other genetically related to oligodendrogliomas. Histologically, those oligoastrocytomas with TP53 mutations were more often astrocytoma-predominant, while those with chromosome 19q loss were more often oligodendro-glioma-predominant.
Genome-Wide Association Study for Anthracycline-Induced Congestive Heart Failure.

PURPOSE Anthracycline-induced congestive heart failure (CHF) is a rare but serious toxicity associated with this commonly employed anticancer therapy. The ability to predict which patients might be at increased risk prior to exposure would be valuable to optimally counsel risk-to-benefit ratio for each patient. Herein, we present a genome-wide approach for biomarker discovery with two validation cohorts to predict CHF from adult patients planning to receive anthracycline. EXPERIMENTAL DESIGN We performed a genome-wide association study in 3,431 patients from the randomized phase III adjuvant breast cancer trial E5103 to identify single nucleotide polymorphism (SNP) genotypes associated with an increased risk of anthracycline-induced CHF. We further attempted candidate validation in two independent phase III adjuvant trials, E1199 and BEATRICE. RESULTS When evaluating for cardiologist-adjudicated CHF, 11 SNPs had a P value <10-5, of which nine independent chromosomal regions were associated with increased risk. Validation of the top two SNPs in E1199 revealed one SNP rs28714259 that demonstrated a borderline increased CHF risk (P = 0.04, OR = 1.9). rs28714259 was subsequently tested in BEATRICE and was significantly associated with a decreased left ventricular ejection fraction (P = 0.018, OR = 4.2). CONCLUSIONS rs28714259 represents a validated SNP that is associated with anthracycline-induced CHF in three independent, phase III adjuvant breast cancer clinical trials. Clin Cancer Res; 23(1); 43-51. ©2016 AACR.
The characterization of butyrate transport across pig and human colonic luminal membrane

1 Luminal membrane vesicles (LMV) were isolated from human and pig colonic tissues. They were characterized in terms of purity and ability to transport [14C]butyrate. 2 The activity of cysteine‐sensitive alkaline phosphatase, and the abundance of villin, NHE2 and NHE3 proteins, markers of the colonic luminal membrane, were significantly enriched in the LMV compared with the original cellular homogenate. The LMV were free from contamination by other cellular organelles and basolateral membranes, as revealed by the negligible presence of either specific marker enzyme activity or characteristic immunogenic protein. 3 The transport of butyrate into the luminal membrane vesicles was enhanced 5‐fold at pH 5.5 compared with pH 8.0. Butyrate transport was temperature dependent, and was stimulated in the presence of an outward‐directed anion gradient in the order of butyrate > bicarbonate > propionate > chloride. Kinetic analysis of increasing substrate concentration showed saturation kinetics with an apparent Km value of 14.8 ± 3.6 mM and a Vmax of 54 ± 14 nmol min−1 (mg protein)−1. 4 Butyrate transport was significantly reduced in the presence of short chain fatty acids (SCFA), acetate, propionate and other monocarboxylates (pyruvate and L‐lactate). Butyrate uptake was inhibited by several cysteine group modifying reagents such as p‐chloromercuribenzosulphonic acid (pCMBS), p‐chloromercuribenzoate (pCMB), mersalyl acid and HgCl2, but not by the stilbene anion exchange inhibitors, 4,4′‐diisothiocyanostilbene‐2,2′‐disulphonate (DIDS) and 4,4′‐dinitrostilbene‐2,2′‐disulphonate (SITS). 5 The described properties of butyrate transport across the luminal pole of the colon suggest the involvement of a carrier protein, in the form of a pH‐activated anion exchange process. The transporter is distinct from the erythrocyte band‐3 type anion exchanger and may belong to the monocarboxylate‐type transport proteins (MCT1).
Predicting progression to lymphoma in Sjögren's syndrome patients

Although the inherent complexity of the multifactorial nature of primary Sjögren's syndrome (pSS) renders the process of disease prognostication and prediction ambiguous, certain clinical and immunological characteristics have been described as lymphoma predictors in several studies. While the association between pSS and mucosa-associated lymphoid tissue lymphomas is indisputable, recent studies report a predominance of diffuse large B-cell lymphomas implying that pSS-lymphoma association is less subtype-specific than previously considered. The considerable differences in both disease severity and prognosis between patients with various types of lymphoma demand the identification of risk factors that can predict the development of the distinct subtypes. Additionally, a recently discovered diverse range of biological variables appears to influence clinical behavior and lymphoma outcome. In this review, we venture into the area of lymphoma prognostication in pSS, outlining long-established predictors, analyzing currently available prognostic models, and exploring the predictive potential of recent biological and molecular advances.
The evolution of performance metrics in the RoboCup Rescue Virtual Robot Competition

This paper presents an overview of the 2007 RoboCup Rescue Virtual Robot Competition and the performance metrics that were used to judge the competition. For this competition, great effort was placed in bringing together researchers with diverse interests to competitively participate. The competition arenas and metrics used for scoring were specifically designed to create a "level" playing field for the various research disciplines. The specific metrics, how they evolved from the prior year's competition, and the way in which the competition was run will be discussed in detail. Defects that were noted in the metrics will also be discussed.
The Opposition Deficit in EU Accountability: Evidence from over 20 Years of Plenary Debate in Four Member States

Debates about the European Union's democratic legitimacy put national parliaments into the spotlight. Do they enhance democratic accountability by offering visible debates and electoral choice about multilevel governance? To support such accountability, saliency of EU affairs in the plenary ought to be responsive to developments in EU governance, has to be linked to decision-making moments and should feature a balance between government and opposition. The recent literature discusses various partisan incentives that support or undermine these criteria, but analyses integrating these arguments are rare. This article provides a novel comparative perspective by studying the patterns of public EU emphasis in more than 2.5 million plenary speeches from the German Bundestag, the British House of Commons, the Dutch Tweede Kamer and the Spanish Congreso de los Diputados over a prolonged period from 1991 to 2015. It documents that parliamentary actors are by and large responsive to EU authority and its exercise where especially intergovernmental moments of decision making spark plenary EU salience. But the salience of EU issues is mainly driven by government parties, decreases in election time and is negatively related to public Euroscepticism. The article concludes that national parliaments have only partially succeeded in enhancing EU accountability and suffer from an opposition deficit in particular.
Rejuvenation capacity of red blood cells in additive solutions over long‐term storage

BACKGROUND: Red blood cells (RBCs) are Food and Drug Administration (FDA)‐approved for 42‐day storage with the use of additive solutions (ASs). However, adenosine triphosphate (ATP) and 2,3‐diphosphoglycerate (2,3‐DPG) levels in the RBCs decline over this time. These constituents may be restored by treatment with rejuvenation (REJ) solutions. This study was done to assess the response capability of RBCs from 30 to 120 days of storage in three FDA‐licensed RBC storage solutions after incubation with a rejuvenating solution of pyruvate, inosine, phosphate, and adenine.