Miracle-dz/UniFAR-FTUs huggingface dataset:
Nodule de Sœur Marie-Josèphe révélateur de carcinomes digestif et ovarien: à propos de 4 cas

Le nodule de Sœur Marie-Josèphe est une métastase ombilicale d'une tumeur le plus souvent intra-abdominale. C'est un signe clinique rare dont l'incidence est de 1-3% de toutes les néoplasies abdomino-pelviennes, avec un pronostic péjoratif du fait de son retard diagnostique. Nous rapportons quatre observations d'une métastase cutanée ombilicale révélatrice d'un adénocarcinome dont deux pancréatiques, un gastrique et un d'origine ovarienne. Le but de notre travail est de montrer à travers ces quatre cas cliniques, l'intérêt de l'imagerie (tomodensitométrie, échographie) et de la biopsie dans la démarche diagnostique. A travers ces quatre observations nous insistons aussi sur les difficultés diagnostiques et thérapeutiques que pose cette tumeur dans nos pays à ressources limitées.
Genetic discontinuities among populations of Cleistes (Orchidaceae, Vanilloideae) in North America.

Genetic patterns were examined in five populations of North American Cleistes with three sources of molecular data: amplified fragment length polymorphisms (AFLP), DNA sequencing, and plastid microsatellites. Populations of C. bifaria were sampled in four areas of the south-eastern US: the coastal plains of Florida and North Carolina and the mountains of North Carolina and West Virginia. A population of C. divaricata sympatric with the North Carolina coastal plain C. bifaria was also sampled. Analysis of the three types of molecular data resulted in the same relationships among the five sampled populations. The coastal plain population of C. divaricata was consistently grouped with the C. bifaria populations from the mountains of West Virginia and North Carolina, and the two coastal plain populations of C. bifaria formed a separate group, results not supporting the existing concepts of species relationships. For future studies, greater sampling of C. divaricata populations and more detailed morphological and phenological studies are recommended for better characterization of the diversity within North American Cleistes. © 2004 The Linnean Society of London, Botanical Journal of the Linnean Society, 2004, 145, 87–95.
Conformational states of beta-lactamase: molten-globule states at acidic and alkaline pH with high salt.

We present evidence that beta-lactamase is close to fully unfolded (i.e., random coil conformation) at low ionic strength at the extremes of pH and that the presence of salt causes a cooperative transition to a conformation with the properties of a molten globule, namely, a compact state with native-like secondary structure but disordered side chains (tertiary structure). The conformation of beta-lactamase I from Bacillus cereus was examined over the pH 1.5-12.5 region by circular dichroism (CD), tryptophan fluorescence, dynamic light scattering, and 1-anilino-8-naphthalenesulfonate (ANS) binding. Under conditions of low ionic strength (I = 0.05) beta-lactamase was unfolded below pH 2.5 and above pH 11.5, on the basis of the far-UV and near-UV CD and tryptophan fluorescence. However, at high ionic strength and low pH an intermediate conformation (state A) was observed, with a secondary structure content similar to that of the native protein but a largely disordered tertiary structure. The transition from the unfolded state (U) to state A induced by KCl was cooperative and had a midpoint at 0.12 M KCl (I = 0.17 M) at pH 1.6. A similar conformation (state B) was observed at high pH and high ionic strength. The transition from the alkaline U state to state B induced by KCl at pH 12.2 was cooperative and had a midpoint at 0.6 M KCl (I = 0.65 M). Light scattering measurements showed that state B was compact although somewhat expanded compared to the N state. The compactness of state A could not be determined due to its strong propensity to aggregate. (ABSTRACT TRUNCATED AT 250 WORDS)
Chronic alcoholics' knowledge regarding tuberculosis.

INTRODUCTION CA are under high risk of developing active TB, very extended forms of TB (with possible lethal outcome) etc. AIM To investigate CA's KN and social stigmatization (ST) regarding TB. METHOD A questionnaire with 22 items (general KN, ST) completed by 115 CA treated for chronic alcoholism on the ward of psychiatry during the year 2000: 97% male, 74% aged 26-45 years, 62% urban, education level (low-35%, middle-59%, high-6%), 8% refugees, 79% smokers. RESULTS 72% know that TB mainly affects the lungs, 75% that TB can be cured, 79% that there is a vaccine against TB, 57% that blood in the sputum is not the only symptom of TB, 22% that there is a connection between TB and AIDS, 33% that there are forms of TB which cannot be cured by standard anti-TB treatment (rural, lower educated/urban, middle educated CA: p = 0.03). 19% would not visit a close friend suffering from TB, 26% would prevent their child from marrying someone who suffered from TB, only 80% would not divorce their spouse if he/she suffered from TB (rural, lower educated/urban, middle educated CA: p = 0.005). Only 35% of the sample know that CAs are under higher risk of developing TB than the general population. CONCLUSIONS 1. KN on TB is not sufficient among CAs. 2. ST of TB is high among CAs. 3. Health education of CAs during hospital treatment must include: information on the danger of tobacco, on the natural history of TB, on high risk of developing TB, on the importance of early self referral when suspected TB symptoms appear, on personal and community related responsibility of each human being regarding TB.
Ef fi cacy of a prevention program for postpartum obsessive e compulsive symptoms

ObsessiveeCompulsive Disorder (OCD) has emerged as a common and impairing postpartum condition. Prospective studies have identified psychological vulnerabilities for the emergence of postpartum obsessiveecompulsive symptoms (OCS), including general anxiety symptoms, pre-existing OCS, and specific cognitive distortions. The identification of these factors makes feasible the development of prevention programs that could reduce the impact of postpartum OCS. The present investigation examined a cognitive-behavioral prevention program using a randomized, double blind, controlled trial. Expecting mothers in their 2nd or 3rd trimester with an empirically established, malleable risk factor for postpartum OCS received either the prevention program (N1⁄4 38) or a credible control program (N1⁄4 33), both of which were incorporated into traditional childbirth education classes. Results revealed that at 1 month, 3 months, and 6 months postpartum, the prevention program was associated with significantly lower levels of obsessions and compulsions than was the control condition (all p’s< 0.05). Group differences remained significant even after controlling for baseline OCS and depression symptoms. Those in the prevention condition also reported decreasing levels of cognitive distortions, in contrast to the control condition (p’s< 0.05). Results support the potential utility of incorporating a CBT-based OCS prevention program into childbirth education classes. 2011 Elsevier Ltd. All rights reserved.
Anaerobic work capacity's contribution to 5-km-race performance in female runners.

PURPOSE The purpose of this study was to examine the relationship between anaerobic characteristics and 5-km-race performance in trained female cross-country runners (N = 13). METHODS The runners performed 50-m sprints and a 5-km time trial on an outdoor 400-m track and maximal anaerobic (MART) and aerobic running tests on a motorized treadmill. Anaerobic characteristics were determined by the mean velocity of the 50-m sprint (v50m) and the peak velocity in the MART (vMART). The aerobic characteristics were obtained during the aerobic treadmill test and included maximal oxygen uptake (VO2max), running economy, and ventilatory threshold (VT). RESULTS Both the vMART (r = .69, P < .01) and VO2max (r = .80, P < .01) correlated with the mean velocity of the 5-km (v5km). A multiple-linear-regression analysis revealed that the combination of VO2max, vMART, and VT explained 81% (R2 = .81, P < .001) of the variation seen in the v5km. The vMART accounted for 31% of the total shared variance, while the combination of VO2max and VT explained the remaining 50%. CONCLUSIONS These results suggest that among trained female runners who are relatively matched, anaerobic energy production can effectively discriminate the v5km and explain a significant amount of the variation seen in 5-km-race performance.
Detection of eight periodontal microorganisms and distribution of Porphyromonas gingivalis fimA genotypes in Chinese patients with aggressive periodontitis.

BACKGROUND The microbiologic feature of aggressive periodontitis (AgP) in Chinese patients has not yet been determined. This study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the Porphyromonas gingivalis fimA genotype in a cohort of Chinese patients with AgP. METHODS Saliva and pooled subgingival plaque samples were collected from 81 patients with AgP (25 with incisor-first molar type and 56 with generalized type [GAgP]) and 34 periodontally healthy controls. Eight periodontal microorganisms, including Aggregatibacter actinomycetemcomitans, P. gingivalis, Tannerella forsythia, Treponema denticola, Campylobacter rectus, Prevotella intermedia, Prevotella nigrescens, and Fusobacterium nucleatum were detected in these samples by the polymerase chain reaction (PCR). In addition, the distribution of fimA genotypes was assessed in P. gingivalis-positive individuals by PCR. RESULTS The prevalence of P. gingivalis, T. forsythia, T. denticola, C. rectus, P. intermedia, F. nucleatum, and A. actinomycetemcomitans in patients with AgP was significantly higher than that in healthy controls. The prevalence of A. actinomycetemcomitans in patients with GAgP was relatively low (30.4%) compared with other pathogens. Results of logistic regression analysis showed that younger patients were more likely to harbor A. actinomycetemcomitans (odds ratio = 2.85). Type II was the most prevalent fimA genotype of P. gingivalis in patients with AgP. CONCLUSIONS P. gingivalis, T. forsythia, T. denticola, C. rectus, P. intermedia, and F. nucleatum were the predominant periodontal pathogens of patients with GAgP in China. Type II of fimA was the most prevalent genotype of P. gingivalis in patients with AgP. The prevalence of A. actinomycetemcomitans in patients with GAgP was relatively low.
Interferon Production in Hamsters Experimentally Infected with Rabies Virus.∗

Summary The induction of interferon by rabies virus was studied in order to establish the status of this virus as an inducer of interferon in the cells it infects. Previous investigators, using in vitro systems, have been unable to demonstrate interferon production from cells infected with rabies virus, and this has caused some confusion among researchers working on rabies. However, using an in vivo system, we were able to isolate and characterize rabies induced interferon from several tissues. The brain, in which the virus reached its highest titer, also contained the largest amount of interferon, with the other levels of interferon corresponding to the centrifugal spread of rabies virus from the brain to the organs.
Microstructure and Magnetic Properties of Low-Fired NiCuZn Ferrite with Different Dopants

The NiCuZn ferrite (Ni<sub>0.60</sub>Cu<sub>0.24</sub>Zn<sub>0.16</sub>Fe<sub>2</sub>O<sub>4</sub>) has been prepared by a conventional solid-reaction method and sintered at 900°C with different dopants to adapt to the low temperature cofired ceramic (LTCC) technology. Two kinds of dopants, oxide Bi<sub>2</sub>O<sub>3</sub> (BI) and ferroelectric ceramic Bi<sub>4</sub>Ti<sub>3</sub>O<sub>12</sub> (BIT), are used in different amounts or combinations (2wt%BI, 2wt%BIT, 2wt%BI + 2wt%BIT, 4wt%BI, and 4wt%BIT) to promote the sintering process. Variation of microstructure and density in each sample has been analyzed. Influence of the doping mode on the magnetic properties of the ferrite has been investigated. It can be found that the ferrite doped with BI has an obvious decrease of both MS and H<sub>C</sub> in contrast with the ferrite doped with same amount of BIT. Appropriate amounts of BIT is helpful to not only increase MS, but also decrease of H<sub>C</sub>, compared with the ferrite without doping.
Monosynaptic inputs to ErbB4‐expressing inhibitory neurons in mouse primary somatosensory cortex

Previous reports have described inputs to the somatosensory cortex (S1) in mouse or rat using retrograde or anterograde tracers. Such studies do not, however, reveal which particular cell types within the S1 cortex receive direct monosynaptic connections from these input sources. Here we describe the monosynaptic inputs to a subpopulation of mouse S1 inhibitory neurons that express ErbB4. We used a previously described “bridge protein,” composed of the ErbB4 ligand, neuregulin (NRG1), fused to the avian viral receptor TVB (TVB‐NRG1), along with EnvB pseudotyped lentivirus (LV) and rabies virus (RV), to selectively coinfect ErbB4‐expressing neurons (Choi et al. [2010] Proc Natl Acad Sci U S A 107:16703–16708). The RV had its glycoprotein gene deleted and replaced with mCherry, so that infected cells express mCherry and the virus cannot spread without provision of rabies glycoprotein (RG) by transcomplementation. The LV encoded and expressed RG to allow transcomplementation in coinfected neurons, so that the RV could spread transsynaptically and label their direct monosynaptic inputs. The RV could not spread beyond the direct inputs, due to the lack of RG in presynaptic cells. This method revealed long‐range connections from thalamus, nucleus basalis, raphe, and distant cortical areas, including ipsilateral motor, secondary somatosensory, retrosplenial, and perirhinal cortex and contralateral S1. In addition, local connections from ipsilateral pyramidal neurons within S1 were labeled. These input sources account for all of the known inputs to S1 described with standard tracers, suggesting that the subpopulation of ErbB4‐positive inhibitory neurons infected using the TVB‐NRG1 bridge protein receives inputs indiscriminately from S1 input sources. J. Comp. Neurol. 519:3402–3414, 2011. © 2011 Wiley‐Liss, Inc.
Spinal Endogenous Acetylcholine Contributes to the Analgesic Effect of Systemic Morphine in Rats

Background Systemic morphine is known to cause increased release of acetylcholine in the spinal cord. Intrathecal injection of the cholinergic receptor agonists or acetylcholinesterase inhibitors produces antinociception in both animals and humans. In the present study, we explored the functional importance of spinal endogenous acetylcholine in the analgesic action produced by intravenous morphine. Methods Rats were implanted with intravenous and intrathecal catheters. The antinociceptive effect of morphine was determined by the paw-withdrawal latency in response to a radiant heat stimulus after intrathecal treatment with atropine (a muscarinic receptor antagonist), mecamylamine (a nicotinic receptor antagonist), or cholinergic neurotoxins (ethylcholine mustard aziridinium ion [AF64A] and hemicholinium-3). Results Intravenous injection of 2.5 mg/kg morphine increased significantly the paw-withdrawal latency. Intrathecal pretreatment with 30 &mgr;g atropine (n = 7) or 50 &mgr;g mecamylamine (n = 6) both attenuated significantly the antinociceptive effect of morphine. The inhibitory effect of atropine on the effect of morphine was greater than that of mecamylamine. Furthermore, the antinociceptive effect of morphine was significantly reduced in rats pretreated with intrathecal AF64A (n = 7) or hemicholinium-3 (n = 6) to inhibit the high-affinity choline transporter and acetylcholine synthesis. We found that intrathecal AF64A reduced significantly the [3H]hemicholinium-3 binding sites but did not affect its affinity in the dorsal spinal cord. Conclusions The data in the current study indicate that spinal endogenous acetylcholine plays an important role in mediating the analgesic effect of systemic morphine through both muscarinic and nicotinic receptors.
Determination of organ pipes' acoustic parameters by means of numerical techniques Orgonasípok akusztikai paramétereinek meghatározása numerikus technikákkal

Kivonat ‐ Az orgonasipok hangkeltesi mechanizmusa rendkivul bonyolult fizikai folyamat, mivel akusztikai es aramlastani jelensegek parhuzamosan, csatolva jelennek meg. Ennek ellenere, pusztan akusztikai rezonatorkent modellezve a sipot, megfelel˝ o pontossaggal becsulhetjuk a hangzas tobb kulcsfontossagu parameteret. A cikk celja az orgonasipok szimulaciojara alkalmas numerikus technikak bemutatasa. Munkam soran tobbfele numerikus eljarast hasznaltam a modellezeshez, melyeket kereskedelmi es sajat fejlesztes ˝ u szoftverekkel valositottam meg. A szimulaciok eredmenyeit analitikus szamitasokkal es meresi adatokkal vetettem ossze. Megmutattam, hogy a numerikus technikak jol alkalmazhatoak a sip f˝ obb akusztikai parametereinek meghatarozasara.
Cognitive deficits in parents from multiple-incidence autism families.

This study compares parents of two autistic children with parents of a Down syndrome (DS) proband, on tests of intelligence, reading and spelling, and executive function. Autism parents performed significantly worse than DS parents on performance IQ, a test of executive function, and some reading measures (e.g. passage comprehension and rapid automatized naming). These results suggest that cognitive deficits may be an expression of the underlying genetic liability for autism and that these characteristics may contribute to a more broadly defined autism phenotype.
Bacterial Inactivation of Transforming Deoxyribonucleate

Competent and noncompetent bacteria are able to bind deoxyribonucleate (DNA). The consequence of this binding is different for the two types of bacteria. Competent bacteria are able to utilize the DNA for transformation. DNA exposed to noncompetent bacteria loses its biological activity with a coincident reduction in the double-stranded molecular weight. The reduction in molecular weight does not appear to be sufficient to account for the loss of biological activity observed.
Effect of antibiotics on the prevalence of enterotoxigenic Escherichia coli in two populations in the Philippines

Hostesses and restaurant employees in the Philippines were studied to determine whether an increased use of antibiotics was associated with a higher point prevalence of enterotoxigenic Escherichia coli. Of 1,030 hostesses and 628 restaurant employees, 28 and 4%, respectively, said that they had taken antibiotics within a week of being cultured (P less than 0.001). Of hostesses and restaurant employees, 10% (103 of 1,030) and 2% (14 of 628), respectively, had antibiotics detectable in their urine (P less than 0.001). Enterotoxigenic E. coli strains were isolated from 1.2% (12 of 1,030) of hostesses and 1.7% (11 of 628) of restaurant employees. In both populations, enterotoxigenic E. coli strains were never found in subjects who had antibacterial activity in their urine. Although resistance to two or more antibiotics was found more frequently in E. coli isolated from hostesses than in that isolated from restaurant workers (48 versus 33%; P less than 0.01), antibiotic selective pressure did not increase the prevalence of enterotoxigenic E. coli in these two populations.
Commonly deleted regions on the long arm of chromosome 21 in differentiated adenocarcinoma of the stomach

During an allelotype analysis of differentiated adenocarcinoma of the stomach, we observed frequent loss of heterozygosity (LOH) on several chromosomes including the long arm of chromosome 21 (21q). Therefore, we analyzed DNA isolated from 45 tumors for LOH at 10 loci on 21q by using polymorphic microsatellite markers. In 20 (44%) of 45 tumors, we detected LOH at single or multiple loci on 21q. Deletion mapping of these 20 tumors revealed two separate commonly deleted regions. Our findings suggest that 21q contains at least two potential tumor suppressor genes which play crucial roles in the development of differentiated adenocarcinoma of the stomach. Genes Chromosom. Cancer 18:318–321, 1997. © 1997 Wiley‐Liss, Inc.
Olga Kirsch se posisie in die Afrikaanse literêre sisteem (1900-1978) / Olga Kirsch’s Position in the Afrikaans Literary System (1900-1978)

Abstract Centrality and marginality are important concepts in polysystem theory, and also in network theory. This article examines Olga Kirsch’s position in the Afrikaans literary system by taking into account data spanning from 1900 to 1978. Overall centrality is discussed from the perspective of network theory and related to polysystem theory, and the concept is also applied to the literary system through the use of the Fruchterman and Reingold (1991) force-directed layout algorithm. It is indicated that Kirsch is positioned on the edge of the core or in the semicore, mainly because there are not so many people from the core who had paid attention to her works, but also because she, according to this data set, did not write on the works of others. It is also indicated which important critics, literary scholars and literary historians paid attention to her works, which contributes to her not being positioned on the periphery.
SEPARATION OF PIGMENTS FROM PETUNIA ’ S PETALS USING THIN LAYER CHROMATOGRAPHY

Anthocyanins are a group of water –soluble pigments found in fruits, vegetables and flowers that give these plants their brilliant colors. The separation of the pigments present in different petals of Petunia hybrida was conducted utilizing thin layer chromatography (TLC). The pigments were extracted from different Petunia’s petals (purple, white and violet) with ethanol prior to being spoted on the TLC plate. The characteristic color of Petunia’s petals is due to a mixture of pigments.
Gene-gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents.

AIMS Multiple genes are likely to be involved in obesity and these genes may interact with environmental factors to influence obesity risk. Our aim was to explore the synergistic contribution of the two polymorphisms: Pro12Ala of the PPAR gamma 2 gene and Trp64Arg of the ADR beta 3 gene to obesity risk in a Spanish children and adolescent population. METHODS We designed a sex- and age-matched case-control study. Participants were 185 obese and 185 control children (aged 5-18 y) from the Navarra region, recruited through Departments of Pediatrics (Hospital Virgen del Camino, Navarra University Clinic and several Primary Health Centers). The obesity criterion (case definition) was BMI above the 97th percentile according to Spanish BMI reference data for age and gender. Anthropometric parameters were measured by standard protocols. The genotype was assessed by PCR-RFLP after digestion with BstUI for PPAR gamma 2 mutation and BstNI for ADR beta 3 variants. Face-to-face interviews were conducted to assess the physical activity. Using a validated physical activity questionnaire, we computed an activity metabolic equivalent index (METs h/week), which represents the physical exercise during the week for each participant. Statistical analysis was performed by conditional logistic regression, taking into account the matching between cases and controls. RESULTS Carriers of the polymorphism Pro12Ala of the PPAR gamma 2 gene had a significantly higher obesity risk than noncarriers (odds ratio (OR)=2.18, 95% CI=1.09-4.36) when we adjusted for sex, age and physical activity. Moreover, the risk of obesity was higher (OR=2.59, 95% CI=1.17-5.34) when family history of obesity was also taken into account in the model. The OR for obesity linked to both polymorphisms (PPAR gamma 2 and ADR beta 3) was 5.30 (95% CI=1.08-25.97) when we adjusted for sex, age and physical activity. After adjustment for family history of obesity, the OR for carriers of both polymorphisms was 19.5 (95% CI=2.43-146.8). CONCLUSIONS A synergistic effect between polymorphism Pro12Ala of the PPAR gamma 2 gene and Trp64Arg of the ADR beta 3 gene for obesity risk was found in a case-control study including children and adolescents.