Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of the treadmill walking exercise on the biochemical bone markers.

OBJECTIVE To study the effects of moderate-intensity treadmill walking exercise on the biochemical bone markers in the menstruating and menopausal women. STUDY DESIGN Experimental study. SETTING Department of Rehabilitation Medicine, King Chulalongkorn Memorial Hospital. MATERIAL AND METHOD Twenty-two healthy volunteer women at the age of 30-70 were recruited: 11 menstruating women and 11 menopausal women. The exercise consisted of the treadmill walking exercise, intensity of 50% of heart rate reserve, for the duration of 30 minutes, at the frequency of 3 times a week, over a 3-month period. Serum beta CTx, PINP and NMID osteocalcin were measured at the baseline and in the 1st, 2nd, and 3rd months. RESULTS Twenty women: 11 menstruating women and 9 menopauses completed the exercise protocol. The baseline characteristics including age, body mass index, serum beta CTx, PINP and NMID were statistically different. The serum beta CTx and NMID levels were decreased from the baseline from Month 1 to 3 in both menstruating and menopausal groups. Serum PINP was not significantly changed in the 1st and 2nd months except the significant decreasing in the 3rd month in the menstruating women. There were no significant differences of bone marker changes between the menstruating women and the menopauses. The biochemical bone markers' levels (beta CTx, PINP and NMID) had the strong correlations analyzed by Pearson's correlation coefficients (> 0.8 with p-value < 0.001). CONCLUSION The present study clearly demonstrates that the moderate intensity treadmill walking exercise for 30 minutes, 3 times a week reduces bone resorption and bone turnover markers in both the menstruating women and the menopauses after the first month until the third month of the experiment. Although the bone formation markers had a tendency of decreasing after exercising, the significant changes showed only in the 3rd month in the menstruating group. All of the bone markers including beta CTx, NMID osteocalcin and PINP were highly correlated.
Human Development as Positive Freedom: A World View Since 1870

points z z Substantial gains in world human development have been achieved since 1870, but research shows that the main improvement actually occurred between the First World War and 1970. z z Across-the-board advances took place in life expectancy and education between 1920 and 1950, a phase during which there was a major backlash against economic globalization. This is evidence of a development puzzle: economic growth and human development do not always go hand in hand. z z Between 1913 and 1970 the absolute gap between most countries in the OECD and the rest of the world widened, with different regions experiencing mixed success in catching up. Since the 1970s the performance of developing regions has varied greatly. z z Despite initial successes in lifting human development, the socialist experiments of the 20th century failed to sustain momentum and then (with the exception of Cuba) stagnated and fell behind prior to the socialist model's ultimate demise. z z Education has been the driving force behind the limited catching-up of developing regions in terms of long-term human development. In terms of life expectancy, these regions achieved significant gains only during the first (early-life) health transition. Since 1970, while most OECD countries have experienced a second (later-life) health transition, all developing regions have fallen behind.
Subdiaphragmatic and intrathoracic paraspinal malignant peripheral nerve sheath tumors

To determine the effects of anatomic site on the presentation and diagnosis of malignant peripheral nerve sheath tumors (MPNSTs) and on the treatment and outcomes of the patients, the authors initiated a study of these tumors at different sites. An earlier report described MPNSTs of the buttock and lower extremity, and the current series analyzes those presenting at intrathoracic (IT) and subdiaphragmatic (SD) paraspinal sites.
Reanalysis of Unruptured Intracranial Aneurysm Management

Objective. This report updates previous clinical decision analysis for patients with unruptured intracranial aneurysm (UN-AN) based on newly published data and discusses the role of reanalysis in individual decision making. Methods. The authors employed probabilities for the natural history of UN-AN and results of preventive surgery based on the report by the International Study of Unruptured Intracranial Aneurysms. Probabilistic sensitivity analysis with Monte Carlo simulation and traditional n-way sensitivity analyses were used to assess the uncertainty of clinical decisions. Results. The baseline decision in favor of preventive surgery is reversed by new data from the international study. Probabilistic sensitivity analyses revealed several populations showing heterogeneity in terms of strategy selection. One- and two-way sensitivity analyses detected two important factors for decision making: annual rupture rate and utility for knowingly living with UN-AN. Conclusions. Annual UN-AN rupture rate and the utility for knowingly living with UN-AN are key factors when deciding on a therapeutic strategy. Also, updating published decision analyses can improve clinical decision making by integrating clinical judgment and newly available clinical data.
NEUROFORM STENT‐ASSISTED COIL EMBOLIZATION OF WIDE‐NECK INTRACRANIAL ANEURYSMS: STRATEGIES IN STENT DEPLOYMENT AND MIDTERM FOLLOW‐UP

OBJECTIVETo evaluate the midterm results of intracranial stent-assisted coil embolization in the treatment of wide-necked cerebral aneurysms and to assess the efficacy of various strategies used in stent deployment. METHODSA retrospective study of 42 patients with 46 wide-necked cerebral aneurysms enrolled in a prospective single-center registry of patients treated with a Neuroform stent (Boston Scientific/Target, Fremont, CA), a flexible self-expanding nitinol stent, was performed. Twenty-seven of 46 aneurysms were unruptured aneurysms, 14 were recanalized aneurysms, and five were acutely ruptured. Thirty-nine aneurysms were located in the anterior and seven in the posterior circulation. Mean aneurysm size was 9.8 mm. Stenting before coiling was performed in 13 of 45 aneurysms (29%), coiling before stenting in 27 of 45 aneurysms (60%), and stenting alone in five of 45 aneurysms (11%). The balloon remodeling technique for coiling before stenting was performed in 77% of patients. Angiographic and clinical follow up was available in 31 patients with 33 aneurysms and ranged from 3 to 24 months. RESULTSNeuroform stenting was attempted in 46 wide-necked aneurysms (42 patients). Forty-nine stent sessions were performed, including three poststent retreatments. In 46 of 49 sessions (94%), successful deployment of 47 stents for 45 aneurysms was obtained. In 40 aneurysms treated with stent-assisted coiling, angiographic results showed 14 (35%) aneurysm occlusions, 18 (45%) neck remnants, and eight (20%) residual aneurysms. In five recanalized aneurysms treated with stenting alone, no changes were observed in four (80%) aneurysms and one (20%) neck remnant reduced in size. At angiographic follow-up in 30 aneurysms treated with stent-assisted coiling, there were 17 (57%) aneurysm occlusions, seven (23%) neck remnants, and six (20%) residual aneurysms. In three recanalized aneurysms treated with stent alone, two (67%) neck remnants remained unchanged and one (33%) neck remnant decreased in size. Procedural morbidity was observed in two of 42 patients (4.8%) and one patient died. On clinical follow-up, the modified Rankin Scale score was 0 in 27 patients (87%), 1 in three patients (10%), and 2 (3%) in one patient. No aneurysm bled during the follow-up period. CONCLUSIONThese results indicate that Neuroform stent-assisted coil embolization is a safe and effective technique in the treatment of wide-necked cerebral aneurysms. Further studies are needed to evaluate the long-term durability of stent-assisted aneurysm occlusion and tolerance to the stent.
The effects of low-protein diets and protease supplementation on broiler chickens in a hot and humid tropical environment

Objective This experiment was conducted to investigate the effects of dietary crude protein (CP) level and exogenous protease supplementation on growth performance, serum metabolites, carcass traits, small intestinal morphology and endogenous protease activity in broiler chickens reared under a tropical climate. Methods A total of 480 day-old male broiler chicks were randomly assigned to eight dietary treatments in a 4×2 factorial arrangement. The main effects were CP level (21.0%, 19.7%, 18.5%, or 17.2% from 1 to 21 days and 19.0%, 17.9%, 16.7%, or 15.6% from 22 to 35 days) and protease enzyme supplementation (0 ppm or 500 ppm). All experimental diets were fortified with synthetic feed-grade lysine, methionine, threonine and tryptophan to provide the minimum amino acid recommended levels for Cobb 500. Results Reducing dietary CP linearly reduced (p<0.05) growth performance, serum albumin, total protein, and carcass traits and increased (p<0.05) serum triglycerides and abdominal fat. There was no consistent effect of reducing dietary CP on morphological parameters of the intestine and on the pancreatic and intestinal endogenous protease activity (p>0.05). Protease supplementation improved (p<0.05) feed conversion ratio, body weight gain, carcass yield and intestinal absorptive surface area. Conclusion Protease supplementation, as measured by growth performance, intestinal morphology and carcass yield, may alleviate the detrimental effects of low protein diets in broiler chickens.
Heparan Sulfate Binding Can Contribute to the Neurovirulence of Neuroadapted and Nonneuroadapted Sindbis Viruses

ABSTRACT Cell culture-adapted laboratory strains of Sindbis virus (SB) exhibit efficient initial attachment to cell surface heparan sulfate (HS) receptors. In contrast, non-cell-adapted strains, such as the SB consensus sequence virus TR339, interact weakly with HS and cell surfaces. Regardless of their HS binding phenotype, most SB strains do not cause fatal disease in adult mice, whether inoculated subcutaneously (s.c.) or intracranially (i.c.). However, laboratory strains of SB can be rendered neurovirulent for adult mice by introduction of a glutamine (Gln)-to-histidine (His) mutation at position 55 of the E2 envelope glycoprotein. In the current work, we have determined that E2 His 55-containing viruses require a second-site mutation (Glu to Lys) at E2 position 70 that confers efficient HS binding in order to exhibit virulence for adult mice and that virulence is correlated with very high infectivity for many cell types. Furthermore, introduction of E2 Lys 70 or certain other HS-binding mutations alone also increased morbidity and/or mortality over that of TR339 for older mice inoculated i.c. However, all viruses containing single HS-binding mutations were attenuated in s.c. inoculated suckling mice in comparison with TR339. These results suggest that HS binding may attenuate viral disease that is dependent on high-titer viremia; however, efficient cell attachment through HS binding can increase virulence, presumably through enhancing the replication of SB within specific host tissues such as the brain.
Revisiting the House Price-Income Relationship

We undertake a systematic analysis of the relationship between house prices and personal income using data for the 50 largest U.S. Metropolitan Statistical Areas (MSAs). We apply state-of-the-art panel data analysis tools, define income in multiple ways, allow for regional heterogeneity, and control for spatial dependence and endogeneity. We find that the house price-income ratio is not stable in the long run for most cities. In contrast, panel regression models that allow for regional heterogeneity and control for cross-sectional dependence yield stationary equations for MSA house prices. Among other findings, we show that relying on panel unit root tests is problematic. We also show that it is important to allow for heterogeneity across locations and to cater for endogeneity and cross-sectional dependence when analyzing the relationship between house prices and income.
Experimental and computational tools useful for (re)construction of dynamic kinase–substrate networks

The explosion of site‐ and context‐specific in vivo phosphorylation events presents a potentially rich source of biological knowledge and calls for novel data analysis and modeling paradigms. Perhaps the most immediate challenge is delineating detected phosphorylation sites to their effector kinases. This is important for (re)constructing transient kinase–substrate interaction networks that are essential for mechanistic understanding of cellular behaviors and therapeutic intervention, but has largely eluded high‐throughput protein‐interaction studies due to their transient nature and strong dependencies on cellular context. Here, we surveyed some of the computational approaches developed to dissect phosphorylation data detected in systematic proteomic experiments and reviewed some experimental and computational approaches used to map phosphorylation sites to their effector kinases in efforts aimed at reconstructing biological signaling networks.
Characterization of the Residues Phosphorylated in Vitro by Different C-terminal Domain Kinases*

The C-terminal part of the largest subunit of eukaryotic RNA polymerase II is composed solely of the highly repeated consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. This domain, called the C-terminal domain (CTD), is phosphorylated mostly at serine residues during transcription initiation, but the precise role of this phosphorylation remains controversial. Several protein kinases are able to phosphorylate this sequence in vitro. The aim of this work was to define the positions of the amino acids phosphorylated by four of these CTD kinases (transcription factor (TF) IIH-kinase, DNA-dependent protein kinase, and the mitogen-activated protein kinases ERK1 and ERK2) and to compare the specificity of these different protein kinases. We show that TFIIH kinase and the mitogen-activated protein kinases phosphorylate only serine 5 of the CTD sequence, whereas DNA-dependent protein kinase phosphorylates serines 2 and 7. Among the different CTD kinases, only TFIIH kinase is appreciably more active on two repeats of the consensus sequence than on one motif. These in vitroresults can provide some clues to the nature of the protein kinases responsible for the in vivo phosphorylation of the RNA polymerase CTD. In particular, the ratio of phosphorylated serine to threonine observed in vivo cannot be explained if TFIIH kinase is the only protein kinase involved in the phosphorylation of the CTD.
High-performance back-illuminated InGaAs/InAlAs MSM photodetector with a record responsivity of 0.96 A/W

A high-performance back-illuminated In/sub 0.53/Ga/sub 0.47/As/In/sub 0.52/Al/sub 0.48/As/InP metal-semiconductor-metal (MSM) detector is reported. A record responsivity of 0.96 A/W at 1.3- mu m wavelength, corresponding to a quantum efficiency of 92%, was measured at 5 V and showed virtually no internal gain at 20 V. Packaged devices with 150- mu m-diameter large detection area showed a 3-dB bandwidth of 4 GHz at 5 V with fiber pigtail butt-coupled package and 3.5 GHz with fiber pigtail silicon V-grooved package. Switching to front-illumination improves the bandwidth by 30-40% with 45-50% reduction of responsivity. Planar and mesa devices both show a low capacitance per unit area of 3.0 nF/cm/sup 2/ and dark current density of 5.6*10/sup -5/ A/cm/sup 2/ at 5 V. Preliminary reliability test results show that the detector biased at 5 V survived temperature cycling of -35 degrees C to 200 degrees C, high-temperature burn-in at 125 degrees C for 168 h and subsequent short-term accelerated aging at 200 degrees C for 120 h without degradation. <<ETX>>
Rethinking place, boundaries, and local history in social studies teacher education

Purpose The purpose of this paper is to report on a qualitative study that examined how pre-service teachers (PSTs) used mobile technology and experiential learning to critically examine the processes that shape places over time. During Summer course work that occurred prior to beginning their field experience and student teaching, participants explored neighborhoods and public spaces, and researched the history as well as contemporary issues relevant to the places in which their future students live, play, work, shop, and go to school. The use of social media as a forum for sharing and reflecting upon their experiences provided opportunity to critique neoliberal and race-based public policies, as well as support reflection on the relationships between geography and teaching about social (in)justice in the social studies. Findings inform the work of teacher educators who seek to help teacher candidates think more deeply about how spatial contexts inform culturally sustaining and critically minded pedagogy in the social studies. Design/methodology/approach This qualitative study included pre- and post-surveys and two one-on-one interviews between research participants and the researcher. Data were also gathered through the use of posts made by participants to a shared social media account. Interested in the interactive process of subjects and their surroundings, symbolic interactionism provided the methodological framework for this study. Findings Involvement in the study provided PSTs with new ways of thinking about how places are shaped over time and the importance of incorporating local intersections of geography and injustice in the classroom. Through experiential learning, PSTs developed a critical understanding of how place relates to who they teach, moved away from deficit thinking about people and places, and, as evidenced in the examples shared, approached lesson planning as place-relevant and culturally sustaining social studies educators. Originality/value The majority of students enrolled in teacher education courses in the USA remains white and it is well documented that most possess few cultural and geographic ties to the schools and students they work with as PSTs. Interested in the intersection of race, place, and teacher education, this paper discusses research conducted with 12 pre-service secondary social studies teachers (PSTs) who were enrolled in an eight-week Summer seminar course that preceded their Fall field experience and Spring student teaching placements to learn how they interpret their movement through spaces and their understanding of how geography, race, and agency intersect and impact students.
Core of HR Strategy: System Thinking and HRM

Research topic of study is to discuss system approach in strategic HRM. It assumes system approaches as core of HR strategy. This study presumes that task performance is key to human resource management. Technical field knowledge increases task performance. Society for Human Resources Management, USA, applies technical HR knowledge for HR professionals in their certification programs. Research question is how various issues of HRM have an impact on effectiveness of HRM. Research methodology contains in-depth literature review to discuss research topic and agenda. Further, study explores various issues related with HRM (Human Resource Management) field. They are personnel management, task performance, economical impact of HRM, and intellectual capital. Firms may compete in isomorphism context by intellectual capital policy. Personnel management is application of implementing organizational jobs by personnel as a traditional method. Task performance is key to employee’s individual and department performance, and impact of HRM on economy may be observed on talent management and intellectual capital. There are three case studies in paper. Therefore, case study methodology is used in the study. This study mentions importance of system approach in strategic HRM field. In conclusion, PM is interested with organizational jobs, and HRM focuses on employees, and performance, which is aligned with resource-based view theory.
Covariance Risk and the Ripple Effect in the UK Regional Housing Market

This study combines two increasingly popular areas of the housing literature, by incorporating a measure of the ripple effect into a model of house price volatility. Using UK data for the English regions and Wales from 1995 to 2016, a multivariate GARCH model is initially used to produce time-varying covariances between house prices in London and other regions. These covariances are then incorporated into an EGARCH model of house price volatility showing that this covariance term is highly significant and positively signed in all regions, such that an increase in the covariance with London has a positive effect on a regioni¯s house prices. However the GARCH term in the mean equation produces a negative risk/return relationship across regional housing markets, although it is not robust to different specifications. This suggests that in the UK, when treating regional housing market risk, policies need to include the relationship of the regioni¯s house prices with those of London. Similar considerations could also apply in other countries exhibiting ripple effects in their housing markets.
Microbial diversity and biomineralization in low-temperature hydrothermal iron-silica-rich precipitates of the Lau Basin hydrothermal field.

Iron-silica-rich low-temperature hydrothermal precipitates were collected from the CDE hydrothermal field located at the East Lau Spreading Center. Phylogenetic analysis showed that the precipitates were dominated by the members of α-proteobacteria and marine group I archaea. Ultrastructural analysis suggested the bacteriogenic origin of the iron-silica-rich deposits. Distinctive biosignatures detected included straight filaments, helical stalks and curved irregular filaments, which were similar in appearance to those structures excreted by the known iron-oxidizing genera Leptothrix spp. , Gallionella spp. and Mariprofundus spp. 16S rRNA gene analysis confirmed the presence of neutrophilic iron-oxidizing bacteria with the detection of phylotypes clustering with Gallionella spp. and the proposed ζ-proteobacteria class. Mineralogy and bulk geochemical analyses showed that the precipitates were dominated by amorphous silica with low amounts of iron. Based on microbiological, geochemical and mineralogical analyses, we conclude that silicification was a common process and microbial cells and related ultrastructures likely acted as nucleation templates for silica precipitation in the CDE hydrothermal field.
Integration of laptop sudden motion sensor as accelerometric control for virtual environments

We have developed a gestural controller for a multimodal client suite using a sudden motion sensor (SMS) deployed with many modern laptop computers. Interpreted commands inferred from the SMS accelerometer can be used to adjust position---orientation and location---of egocentric perspectives and exocentric avatars to control panoramic browsing and spatialized sound, adjusting the lateralization, directionalization, and spatialization of musical and audio channels.