Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and Evaluation of a Low-Cost Force Feedback System for Myoelectric Prosthetic Hands

Myoelectrically powered prosthetic hands lack sensory feedback relating to the force exerted by the artificial hand on a grasped object. The degree of control is imprecise, and often much more force than necessary is applied. The aim of this study was to develop and evaluate a force feedback system considering design constraints, providing the user with closed-loop control. Different methods and design criteria for providing myoelectric prosthetic hands with force feedback were analyzed, with stimulation by vibration being preferred. A new feedback system was designed, consisting of a miniature vibration motor, a piezoresistive force sensor, and control electronics. Grasping forces with and without feedback were recorded and compared from five habitual myoelectric hand users when grasping a hand dynamometer with different weights attached to it. All five patients rapidly improved their ability to regulate the grasping force without the help of vision when feedback was applied. An average force reduction of 37% was found when vibration was applied indirectly to the hand, and a decrease of 54% was found when feedback was applied directly to the skin of the residual limb. Constraints for a prosthetic force feedback system such as low power consumption, compactness, and being imperceptible to others are included in the design. General acceptance of vibration as a feedback signal was good, especially when applied indirectly. The results indicate that the new system is of potential value for myoelectric prosthetic hand users. More precise control is possible, and redundant grasping force can be diminished with a feedback system.
Psychosocial Status of Homeless Children and Youth in Family Supportive Housing

Shelter-based studies have documented risks to homeless children's development, but scant information is available about children residing in family supportive housing, a key strategy for preventing long-term homelessness. This study assessed the psychosocial and health status of 454 formerly homeless children living with their families in 17 supportive housing communities. Findings indicated that children had good access to physical health care. However, children faced significant psychosocial risks and manifested behavioral, emotional, and school challenges. Housing agencies lacked infrastructure or expertise in children's mental health. The authors propose that supportive housing provides a valuable but hitherto underused opportunity to support children's psychosocial functioning.
Dual Molecular Signals Mediate the Bacterial Response to Outer-Membrane Stress

Stress Inside Out In Gram-negative bacteria, the integrity of the outer membrane is crucial for survival and is an important aspect of resistance to antibiotics. The biogenesis of the major components lipopolysaccharide (LPS) and outer-membrane protein (OMP) of the outer membrane begins in the cytoplasmic compartment, involves export across the inner membrane and transport through the periplasm, and finally requires active insertion into the outer membrane by specialized assembly machines. Lima et al. (p. 837) supply results for a model in which serious defects in LPS biogenesis also create problems for OMP biogenesis, thereby producing the two signals needed to activate the σE stress response pathway. Gram-negative bacteria monitor lipopolysaccharide and outer-membrane protein status to detect and respond to problems. In Gram-negative bacteria, outer-membrane integrity is essential for survival and is monitored by the σE stress-response system, which initiates damage-repair pathways. One activating signal is unassembled outer-membrane proteins. Using biochemical and genetic experiments in Escherichia coli, we found that off-pathway intermediates in lipopolysaccharide transport and assembly provided an additional required signal. These distinct signals, arising from disruptions in the transport and assembly of the major outer-membrane components, jointly determined the rate of proteolytic destruction of a negative regulator of the σE transcription factor, thereby modulating the expression of stress-response genes. This dual-signal system permits a rapid response to dysfunction in outer-membrane biogenesis, while buffering responses to transient fluctuations in individual components, and may represent a broad strategy for bacteria to monitor their interface with the environment.
Safe Treatment of Pulmonary Hypertension With Bosentan in a Patient With Moyamoya Disease and Cerebral Ischemia

A 7-year-old girl with Down syndrome and moderately severe pulmonary hypertension experienced a stroke while being treated with a calcium channel blocker. Angiography identified bilateral stenosis of the supraclinoid internal carotid arteries, stenosis or occlusion of the proximal anterior and middle cerebral arteries, and occlusion of the left posterior cerebral artery. She underwent surgery to enhance collateral blood flow to vulnerable areas of the brain. Her pulmonary hypertension therapy was changed to an oral endothelin receptor antagonist. She developed excellent collateral blood flow through external carotid arteries to each cerebral hemisphere and an improvement in blood flow through the right internal carotid artery. This case suggests that bosentan can be used safely in children with moyamoya disease. Additional studies are needed to determine whether endothelin receptor antagonists may influence the progression of moyamoya disease or the development of collateral cerebral blood flow following surgery.
Backstepping observer based-control for an anti-damped boundary wave PDE in presence of in-domain viscous damping

This paper presents a backstepping control design for a one-dimensional wave PDE with in-domain viscous damping, subject to a dynamical anti-damped boundary condition. Its main contribution is the design of an observer-based control law which stabilizes the wave PDE velocity, using only boundary mesurements. Numerical simulations on an oil-inspired example show the relevance of our result and illustrate the merits of this control design.
Space Partitioning Without Territoriality in Gannets

This Is the Place Bats, bees, seals, and many seabirds practice central-place foraging, leaving a central home site, such as a hive or a rookery, to forage in a specific territory. Such species also share the challenge of competing for local resources with individuals from separate colonies. Using satellite tags, Wakefield et al. (p. 68, published online 6 June; see the Perspective by Weimerskirch) followed over 180 northern gannets to determine potential drivers of foraging territory division. Boundaries among colonial territories arose as a result of competition with individuals from other territories. Individuals from the same colony appeared to share information about foraging sites, presumably contributing to the establishment and maintenance of specific, long-term colonial territories. Gannets establish foraging territory boundaries in colonies through local competition and information exchange. [Also see Perspective by Weimerskirch] Colonial breeding is widespread among animals. Some, such as eusocial insects, may use agonistic behavior to partition available foraging habitat into mutually exclusive territories; others, such as breeding seabirds, do not. We found that northern gannets, satellite-tracked from 12 neighboring colonies, nonetheless forage in largely mutually exclusive areas and that these colony-specific home ranges are determined by density-dependent competition. This segregation may be enhanced by individual-level public information transfer, leading to cultural evolution and divergence among colonies.
Wolbachia Invades Anopheles stephensi Populations and Induces Refractoriness to Plasmodium Infection

Infections Against Infection In the same way that infection with the bacteria Wolbachia spp. can make Aedes mosquitoes resistant to dengue virus, there have been hints that these bacteria can interfere with the reproduction of malaria parasites. Bian et al. (p. 748) established a heritable Wolbachia infection in anopheline mosquitoes, which simultaneously suppressed the reproduction of malaria parasites within the adult female mosquitoes. The results hold promise for developing the model into a biocontrol agent to assist malaria control. Stable inheritance of a symbiotic bacterium suppresses malaria parasites in mosquitoes. Wolbachia is a maternally transmitted symbiotic bacterium of insects that has been proposed as a potential agent for the control of insect-transmitted diseases. One of the major limitations preventing the development of Wolbachia for malaria control has been the inability to establish inherited infections of Wolbachia in anopheline mosquitoes. Here, we report the establishment of a stable Wolbachia infection in an important malaria vector, Anopheles stephensi. In A. stephensi, Wolbachia strain wAlbB displays both perfect maternal transmission and the ability to induce high levels of cytoplasmic incompatibility. Seeding of naturally uninfected A. stephensi populations with infected females repeatedly resulted in Wolbachia invasion of laboratory mosquito populations. Furthermore, wAlbB conferred resistance in the mosquito to the human malaria parasite Plasmodium falciparum.
Corpus Callosum Morphology and Its Relationship to Cognitive Function in Neurofibromatosis Type 1

Neurofibromatosis type 1 (NF1) is associated with cognitive dysfunction and structural brain abnormalities such as an enlarged corpus callosum. This study aimed to determine the relationship between corpus callosum morphology and cognitive function in children with neurofibromatosis type 1 using quantitative neuroanatomic imaging techniques. Children with neurofibromatosis type 1 (n = 46) demonstrated a significantly larger total corpus callosum and corpus callosum index compared with control participants (n = 30). A larger corpus callosum index in children with neurofibromatosis type 1 was associated with significantly lower IQ, reduced abstract concept formation, reduced verbal memory, and diminished academic ability, specifically reading and math. Our results suggest an enlarged corpus callosum in children with neurofibromatosis type 1 is associated with cognitive impairment and may provide an early structural marker for the children at risk of cognitive difficulties. Cognitive deficits associated with structural brain abnormalities in neurofibromatosis type 1 are unlikely to be reversible and so may not respond to proposed pharmacological therapies for neurofibromatosis type 1-related cognitive impairments.
A Population of Fast Radio Bursts at Cosmological Distances

Mysterious Radio Bursts It has been uncertain whether single, short, and bright bursts of radio emission that have been observed are celestial or terrestrial in origin. Thornton et al. (p. 53; see the Perspective by Cordes) report the detection of four nonrepeating radio transient events with millisecond duration in data from the 64-meter Parkes radio telescope in Australia. The properties of these radio bursts indicate that they had their origin outside our galaxy, but it is not possible to tell what caused them. Because the intergalactic medium affects the characteristics of the bursts, it will be possible to use them to study its properties. Radio telescope data revealed four short, extragalactic, nonrepeating bursts of radio emission whose source is unknown. [Also see Perspective by Cordes] Searches for transient astrophysical sources often reveal unexpected classes of objects that are useful physical laboratories. In a recent survey for pulsars and fast transients, we have uncovered four millisecond-duration radio transients all more than 40° from the Galactic plane. The bursts’ properties indicate that they are of celestial rather than terrestrial origin. Host galaxy and intergalactic medium models suggest that they have cosmological redshifts of 0.5 to 1 and distances of up to 3 gigaparsecs. No temporally coincident x- or gamma-ray signature was identified in association with the bursts. Characterization of the source population and identification of host galaxies offers an opportunity to determine the baryonic content of the universe.
The Future of Species Under Climate Change: Resilience or Decline?

As climates change across already stressed ecosystems, there is no doubt that species will be affected, but to what extent and which will be most vulnerable remain uncertain. The fossil record suggests that most species persisted through past climate change, whereas forecasts of future impacts predict large-scale range reduction and extinction. Many species have altered range limits and phenotypes through 20th-century climate change, but responses are highly variable. The proximate causes of species decline relative to resilience remain largely obscure; however, recent examples of climate-associated species decline can help guide current management in parallel with ongoing research.
A HyperTransport chip-to-chip interconnect tunnel developed using SystemC

This paper presents a HyperTransport (HT) tunnel developed in hardware with SystemC. HT is an excellent technology for implementing flexible high performance system switch fabrics applicable to rapid system prototyping. An overview of the proposed architecture is presented, followed by synthesis results. Performance analysis shows that, when configured as an 8-bit link and implemented in a 0.18/spl mu/m CMOS standard cell technology, the design can operate at 400 mega transfers/s. This paper discusses the advantages and drawbacks of working with SystemC to perform large scale hardware implementations.
Martian Fluvial Conglomerates at Gale Crater

Going to Mars The Mars Science Laboratory spacecraft containing the Curiosity rover, was launched from Earth in November 2011 and arrived at Gale crater on Mars in August 2012. Zeitlin et al. (p. 1080) report measurements of the energetic particle radiation environment inside the spacecraft during its cruise to Mars, confirming the hazard likely to be posed by this radiation to astronauts on a future potential trip to Mars. Williams et al. (p. 1068, see the Perspective by Jerolmack) report the detection of sedimentary conglomerates (pebbles mixed with sand and turned to rock) at Gale crater. The rounding of the rocks suggests abrasion of the pebbles as they were transported by flowing water several kilometers or more from their source. Observations from the Curiosity rover of rounded pebbles in sedimentary rocks confirm ancient water flows on Mars. [Also see Perspective by Jerolmack] Observations by the Mars Science Laboratory Mast Camera (Mastcam) in Gale crater reveal isolated outcrops of cemented pebbles (2 to 40 millimeters in diameter) and sand grains with textures typical of fluvial sedimentary conglomerates. Rounded pebbles in the conglomerates indicate substantial fluvial abrasion. ChemCam emission spectra at one outcrop show a predominantly feldspathic composition, consistent with minimal aqueous alteration of sediments. Sediment was mobilized in ancient water flows that likely exceeded the threshold conditions (depth 0.03 to 0.9 meter, average velocity 0.20 to 0.75 meter per second) required to transport the pebbles. Climate conditions at the time sediment was transported must have differed substantially from the cold, hyper-arid modern environment to permit aqueous flows across several kilometers.
Terabit-Scale Orbital Angular Momentum Mode Division Multiplexing in Fibers

A Twist on the Capacity Crunch The rate at which data can be transmitted down optic fibers is approaching a limit because of nonlinear optical effects. Multiplexing allows data to be encoded in different modes of light such as polarization, wavelength, amplitude, and phase and to be sent down the fibers in parallel. Optical angular momentum (OAM) can provide another degree of freedom whereby the photons are given a well-defined twist or helicity. Bozinovic et al. (p. 1545) were able to transmit high-bandwidth data using OAM modes in long lengths of optical fibers, thus providing a possible route to get yet more capacity through optic fiber networks. Encoding data in the twist, or helicity, of photons provides a route to increase optical communication rates in fibers. Internet data traffic capacity is rapidly reaching limits imposed by optical fiber nonlinear effects. Having almost exhausted available degrees of freedom to orthogonally multiplex data, the possibility is now being explored of using spatial modes of fibers to enhance data capacity. We demonstrate the viability of using the orbital angular momentum (OAM) of light to create orthogonal, spatially distinct streams of data-transmitting channels that are multiplexed in a single fiber. Over 1.1 kilometers of a specially designed optical fiber that minimizes mode coupling, we achieved 400-gigabits-per-second data transmission using four angular momentum modes at a single wavelength, and 1.6 terabits per second using two OAM modes over 10 wavelengths. These demonstrations suggest that OAM could provide an additional degree of freedom for data multiplexing in future fiber networks.
Familial Miller Fisher Syndrome

Miller Fisher syndrome is an acute inflammatory polyradiculoneuropathy that is generally considered a variant of Guillain-Barré syndrome and is characterized by the clinical triad of ataxia, areflexia, and ophthalmoplegia. Several reports of familial Guillain-Barré syndrome have been reported, indicating a possible underlying genetic and/or environmental predisposition to the development of Guillain-Barré syndrome. A familial association in Miller Fisher syndrome has not previously been described in the literature. We report 2 cases of Miller Fisher syndrome presenting simultaneously in siblings, with a review of recent relevant literature.
FPGA-based HPC application design for non-experts

In the current era of big-data computing, most non-engineer domain experts lack the skills needed to design FPGA-based hardware accelerators to address big-data problems. This work presents bFlow, a development environment that facilitates the assembly of such accelerators, specifically those targeting FPGA-based hybrid computing platforms, such as the Convey HC series. This framework attempts to address the above problem by making use of an abstracted, graphical front-end more friendly to users without computer engineering backgrounds than traditional tools, as well as by accelerating bitstream compilation by means of incremental implementation techniques. bFlow's performance, usability, and application to big-data life-science problems was tested by participants of an NSF-funded Summer Institute organized by the Virginia Bioinformatics Institute (VBI). In about one week, a group of four non-engineering participants made significant modifications to a reference Smith-Waterman implementation, adding functionality and scaling theoretical throughput by a factor of 32.
Thermal-aware task scheduling for peak temperature minimization under periodic constraint for 3D-MPSoCs

3D-MPSoC offer great performance and scalability benefits. However, due to strong vertical thermal correlation and increased power density, thermal challenges in 3D-MPSoC are critical. In this paper, we propose a novel thermal aware task scheduling technique that combine intelligent task mapping with DVFS to minimize the peak temperature of the system. Particularly, our approach leverages on the fundamental thermal characteristics of 3D architecture when mapping tasks to processing cores and employing DVFS at design time followed by a simple thermal optimization step at run time. Our experiments validate the efficiency of our approach in peak temperature minimization up to 14°C compared to other existing methods.
A Stem Cell Perspective on Cellular Engineering

Alternative ways of engineering cells in vitro are being tested to realize their therapeutic potential. A fundamental enigma in modern biology concerns the molecular rules that govern how cells establish and maintain identity during development. These rules are the key to generating therapeutic cell types in vitro and the foundation of regenerative medicine. The isolation of embryonic stem cells (ESCs) has enabled scientists to recapitulate the process of embryonic development in a dish, by directing differentiation of ESCs with combinations of morphogens and growth factors to mimic embryonic development. These experiments assume that cell and tissue fates evolve along specific paths, and once established, remain fixed. But the advent of cellular reprogramming has fundamentally altered our view of the stability of cell identity, and dramatic demonstrations of the interconversions of mature cell types have introduced the provocative idea that cell identity can be engineered to play beneficial therapeutic roles.
Maternal AP determinants in the Drosophila oocyte and embryo

An animal embryo cannot initiate its journey of forming a new life on its own. It must rely on maternally provided resources and inputs to kick‐start its developmental process. In Drosophila, the initial polarities of the embryo along both the anterior–posterior (AP) and dorsal–ventral (DV) axes are also specified by maternal determinants. Over the past several decades, genetic and molecular studies have identified and characterized such determinants, as well as the zygotic genetic regulatory networks that control patterning in the early embryo. Extensive studies of oogenesis have also led to a detailed knowledge of the cellular and molecular interactions that control the formation of a mature egg. Despite these efforts, oogenesis and embryogenesis have been studied largely as separate problems, except for qualitative aspects with regard to maternal regulation of the asymmetric localization of maternal determinants. Can oogenesis and embryogenesis be viewed from a unified perspective at a quantitative level, and can that improve our understanding of how robust embryonic patterning is achieved? Here, we discuss the basic knowledge of the regulatory mechanisms controlling oogenesis and embryonic patterning along the AP axis. We explore properties of the maternal Bicoid gradient in relation to embryo size in search for a unified framework for robust AP patterning. WIREs Dev Biol 2016, 5:562–581. doi: 10.1002/wdev.235
Infantile-Onset Disorders of Mitochondrial Replication and Protein Synthesis

Most inherited mitochondrial diseases in infants result from mutations in nuclear genes encoding proteins with specific functions targeted to the mitochondria rather than primary mutations in the mitochondrial DNA (mtDNA) itself. In the past decade, a growing number of syndromes associated with dysfunction resulting from tissue-specific depletion of mtDNA have been reported in infants. MtDNA depletion syndrome is transmitted as an autosomal recessive trait and causes respiratory chain dysfunction with prominent neurological, muscular, and hepatic involvement. Mendelian diseases characterized by defective mitochondrial protein synthesis and combined respiratory chain defects have also been described in infants and are associated with mutations in nuclear genes that encode components of the translational machinery. In the present work, we reviewed current knowledge of clinical phenotypes, their relative frequency, spectrum of mutations, and possible pathogenic mechanisms responsible for infantile disorders of oxidative metabolism involved in correct mtDNA maintenance and protein production.