Miracle-dz/UniFAR-FTUs huggingface dataset:
Effective treatment for hypertrophic scar with dual-wave-length PDL and Nd:YAG in Chinese patients

ABSTRACT There are several ways to prevent and treat hypertrophic scars. In recent years, lasers have been quite extensively used in treating scars. For example, Pulsed Dye Laser (PDL) and Intense Pulsed Light (IPL) can accelerate mutation of scar, whereas non-ablative and ablative fractional laser can improvescar texture. Dual-wave-length laser treatment is extensively used for blood vessel diseases but is rarely used and less reported for treatment of hypertrophic scars. Our study focuses on the efficacy and safety of dual-wave-length PDL and Nd:YAG in treatment of hypertrophic scars. Twenty-five patients in our study complaining of hypertrophic scars were treated with combined PDL/Nd:YAG laser at 4-6 weeks intervals. Following this, the patients and observers assessed these scars by using Patient Scar Assessment Scale (PSAS) and Observer Scar Assessment Scale (OSAS). The resultsshowed that hypertrophic scar was significantly improved after several laser treatments, and no severe adverse effects were observed. Considering the safety and satisfactory effects of dual-wave-length laser treatment, it can be regarded as a good method for treating hypertrophic scars. This study clearly demonstrates that combined PDL/Nd:YAG laser treatment is an effective, safe and well-tolerated treatment option for hypertrophic scars.
Flexible Strain Sensor Based on Carbon Black/Silver Nanoparticles Composite for Human Motion Detection

The demand for flexible and wearable electronic devices with excellent stretchability and sensitivity is increasing, especially for human motion detection. In this work, a simple, low-cost and convenient strategy has been employed to fabricate flexible strain sensor with a composite of carbon black and silver nanoparticles as sensing materials and thermoplastic polyurethane as matrix. The strain sensors thus prepared possesses high stretchability and good sensitivity (gauge factor of 21.12 at 100% tensile strain), excellent static (almost constant resistance variation under 50% strain for 600 s) and dynamic (100 cycles) stability. Compared with bare carbon black-based strain sensor, carbon black/silver nanoparticles composite-based strain sensor shows ~18 times improvement in sensitivity at 100% strain. In addition, we discuss the sensing mechanisms using the disconnection mechanism and tunneling effect which results in high sensitivity of the strain sensor. Due to its good strain-sensing performance, the developed strain sensor is promising in detecting various degrees of human motions such as finger bending, wrist rotation and elbow flexion.
Ağız Bilimi Çalışmalarının Türkçe Öğretimi Açısından Önemi

Ural-Altay Dilleri arasinda yer alan ve gunumuzde 12 milyon m²’lik bir alanda yaklasik 220 milyon kisi tarafindan konusulan Turkce, dunyanin bilinen en eski ve en zengin dillerinden biridir. Turkcenin farkli cografyalarda, oldukca fazla kisi tarafindan iletisim, bilim ve sanat dili olarak kullanilmasi, farkli lehce ve agizlarinin da olusmasi Turkcenin gelismisliginin ve zenginliginin de gostergesidir. Turkcenin tarihi ve cagdas lehceleriyle ve agizlariyla ilgili bugune kadar pek cok mustakil eser yayimlanmistir. Turkce ogretimiyle ilgili de ozellikle son yillarda birbirinden degerli eserlerin yayimlandigi bilinmektedir. Ancak Turkce ogretiminde agizlarin ve agiz arastirmalarinin rolu ve onemi uzerinde yeterince durulmamis; Turkcenin egitimi ve ogretimi alaninda agiz bilimi ile ilgili calismalardan da yeterince yararlanilmamistir. Bunda Turkcenin egitimi ve ogretimi alaninda calisanlarin / ogretenlerin kendi alanlari disinda kalan alanlara kayitsiz kalmalarinin, dil bilimi, dil bilgisi, Turk lehceleri ve bu baglamda agiz bilimi ile ilgili yeterli bilgi ve birikime sahip olmamalarinin rolu buyuktur. Bu makalede Turkcenin egitimi ve ogretiminde agizlarin ve agiz bilimi arastirmalarinin rolu ve onemi hakkinda bilgi verilmektedir.
Zeb1 Regulates the Symmetric Division of Mouse Lewis Lung Carcinoma Stem Cells through Numb mediated by miR-31

Symmetric cell division (SD) and asymmetric cell division (ASD) were the unique characteristics of stem cells and the mechanisms underlying stem cell renewal. While recent studies have identified the presence of SD and ASD in lung cancer stem cells (CSCs), the mechanisms regulating SD and ASD in cancer state have not been elucidated, mostly due to the lack of stable cellular models of SD and ASD in CSC research. In this study, the interaction between Zeb1, an Epithelial-Mesenchymal Transition (EMT) factor shown to regulate CSCs self-renew, and Numb, which regulates SD and ASD in the normal neural stem cell was investigated using the stable mouse Lewis lung adenocarcinoma SD (LLC-SD) and ASD (LLC-ASD) lines established from our previous study. The most significant finding derived from this line of research is that we have identified and molecularly ordered the axis of Zeb1-miR-31-Numb that regulates the SD, a mechanism of CSC self-renewal that has not been previously described. More specifically, the expression of Zeb1 and Numb were both significantly higher in LLC-SD than LLC-ASD cells. Silencing of Zeb1 or Numb expression lead to decreased ratio of SD and weakened single-cell cloning formation, tumor growth and tumor metastasis, respectively. The rescure experiments have molecularly ordered the regulation of Numb by Zeb1, indirectly mediated by miR-31. Moreover, we also provided preliminary evidence supporting the clinical relevance of our finding. In summary, our study provides a new insight for the self-renew of lung CSCs in which SD is regulated by the axis of Zeb1-miR-31-Numb.
Antiviral Mechanism of Action of Epigallocatechin-3-O-gallate and Its Fatty Acid Esters

Epigallocatechin-3-O-gallate (EGCG) is the major catechin component of green tea (Cameria sinensis), and is known to possess antiviral activities against a wide range of DNA viruses and RNA viruses. However, few studies have examined chemical modifications of EGCG in terms of enhanced antiviral efficacy. This paper discusses which steps of virus infection EGCG interferes with, citing previous reports. EGCG appears most likely to inhibits the early stage of infections, such as attachment, entry, and membrane fusion, by interfering with viral membrane proteins. According to the relationships between structure and antiviral activity of catechin derivatives, the 3-galloyl and 5′-OH group of catechin derivatives appear critical to antiviral activities. Enhancing the binding affinity of EGCG to virus particles would thus be important to increase virucidal activity. We propose a newly developed EGCG-fatty acid derivative in which the fatty acid on the phenolic hydroxyl group would be expected to increase viral and cellular membrane permeability. EGCG-fatty acid monoesters showed improved antiviral activities against different types of viruses, probably due to their increased affinity for virus and cellular membranes. Our study promotes the application of EGCG-fatty acid derivatives for the prevention and treatment of viral infections.
Childhood Overweight, Tallness, and Growth Increase Risks of Ovarian Cancer

Background: Adult body size is related to ovarian cancer risks, but size in childhood may also influence risks. We investigated if childhood body mass index (kg/m2), height, and growth patterns were associated with ovarian cancer overall and by histologic subtypes, including effects of birthweight. Methods: A cohort of 155,958 girls from the Copenhagen School Health Records Register, born 1930 to 1989 with measured weights and heights from 7 to 13 years, were included. During follow-up, 1,041 ovarian cancers were recorded. Overweight was defined using International Obesity Task Force criteria. Cox regressions were performed. Results: Compared with non-overweight girls, at most ages girls with overweight had increased risks of ovarian cancer overall (HR range: 1.24–1.34), mucinous, endometrioid, and clear cell ovarian cancers, but not serous and other ovarian cancers. Childhood height had positive and significant associations with ovarian cancer overall (HR range: 1.07–1.10 per z-score) and the endometrioid subtype but not with the other subtypes. Adjusting for birthweight minimally altered the associations with childhood body size. In growth analyses, girls with overweight or who were tall at 7 and 13 years had increased risks of ovarian cancer overall compared with average-sized girls at both ages. Conclusions: Ovarian carcinogenesis is linked to childhood overweight, tallness, and growth, with variations across histological subtypes, suggesting that early life plays a role in the origins of this disease. Impact: These findings emphasize that healthy body size and growth during childhood are important as they may contribute to reducing ovarian cancer risks.
Infection with flaviviruses requires BCLXL for cell survival

BCL2 family proteins including pro-survival proteins, BH3-only proteins and BAX/BAK proteins control mitochondria-mediated apoptosis to maintain cell homeostasis via the removal of damaged cells and pathogen-infected cells. In this study, we examined the roles of BCL2 proteins in the induction of apoptosis in cells upon infection with flaviviruses, such as Japanese encephalitis virus, Dengue virus and Zika virus. We showed that survival of the infected cells depends on BCLXL, a pro-survival BCL2 protein due to suppression of the expression of another pro-survival protein, MCL1. Treatment with BCLXL inhibitors, as well as deficient BCLXL gene expression, induced BAX/BAK-dependent apoptosis upon infection with flaviviruses. Flavivirus infection attenuates cellular protein synthesis, which confers reduction of short-half-life proteins like MCL1. Inhibition of BCLXL increased phagocytosis of virus-infected cells by macrophages, thereby suppressing viral dissemination and chemokine production. Furthermore, we examined the roles of BCLXL in the death of JEV-infected cells during in vivo infection. Haploinsufficiency of the BCLXL gene, as well as administration of BH3 mimetic compounds, increased survival rate after challenge of JEV infection and suppressed inflammation. These results suggest that BCLXL plays a crucial role in the survival of cells infected with flaviviruses, and that BCLXL may provide a novel antiviral target to suppress propagation of the family of Flaviviridae viruses.
Psychometric evaluation of the Persian Internet Disorder Scale among adolescents

Background and aims Given the growing epidemiological research interest concerning Internet addiction, brief instruments with a robust theoretical basis are warranted. The Internet Disorder Scale (IDS-15) is one such instrument that can be used to quickly assess the Internet addiction in an individual. However, only two language versions of the IDS-15 have been developed. This study translated the IDS-15 into Persian and examined its psychometric properties using comprehensive psychometric testing. Methods After ensuring the linguistic validity of the Persian IDS-15, 1,272 adolescents (mean age = 15.53 years; 728 males) completed the IDS-15, Depression Anxiety Stress Scale (DASS), Internet Gaming Disorder Scale – Short Form (IGDS9-SF), and the Bergen Social Media Addiction Scale (BSMAS). Confirmatory factor analysis (CFA), Rasch models, regression analysis, and latent profile analysis (LPA) were carried out to test the psychometric properties of the Persian IDS-15. Results Both CFA and Rasch supported the construct validity of the Persian IDS-15. Multigroup analysis in CFA and differential item functioning in Rasch indicated that male and female adolescents interpreted the IDS-15 items similarly. Regression analysis showed that the IDS-15 correlated with IGDS9-SF and BSMAS (ΔR2 = .12 and .36, respectively) is stronger than the DASS (ΔR2 = .03–.05). LPA based on IDS-15 suggests three subgroups for the sample. Significant differences in depression, anxiety, IGDS9-SF, and BSMAS were found among the three LPA subgroups. Conclusion The Persian IDS-15 has robust psychometric properties as evidenced by both classical test theory and Rasch analysis.
RNA modifications modulate gene expression during development

RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example, N6-methyladenosine (m6A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications in transfer RNAs are essential for RNA structure and function. Others are deposited in response to external cues and adapt global protein synthesis and gene-specific translational accordingly and thereby facilitate proper development.
Bio-Inspired Neural Adaptive Control of a Small Unmanned Aerial Vehicle Based on Airflow Sensors

Inspired by the exceptional flight ability of birds and insects, a bio-inspired neural adaptive flight control structure of a small unmanned aerial vehicle was presented. Eight pressure sensors were elaborately installed in the leading-edge area of the forward wing. A back propagation neural network was trained to predict the aerodynamic moment based on pressure measurements. The network model was trained, validated, and tested. An adaptive controller was designed based on a radial basis function neural network. The new adaptive laws guaranteed the boundedness of the adaptive parameters. The closed-loop stability was analyzed via Lyapunov theory. The simulation results demonstrated the robustness of the bio-inspired flight control system when subjected to measurement noise, parametric uncertainties, and external disturbance.
Radiation protection in therapy with radiopharmaceuticals

Abstract Purpose: Radionuclide therapy (RNT) involves the selective delivery of radiation, emitted from radionuclides to tumors or target organs. The techniques of RNT are increasingly being used for the treatment of various tumors. The purpose of this article is to report on the current state of RNT, to clarify the issues of radiation protection associated with RNT, and to show future prospects. Results and conclusions: Medical exposure of patients has unique features; application of dose limits is not undertaken, and justification and optimization do apply but in a different way from in other exposures. The expanding use of RNT has raised concern regarding potential carcinogenic and leukemogenic effects and research on second primary cancer after RNT have been developing. RNT combined with imaging and dosimetry and featuring a theranostic approach is undergoing a significant expansion, and such dosimetry-based treatment planning leads to individualization, or personalization, which is likely to improve the effectiveness and safety of patient management in RNT.
The effect of increased concentration of carbon dioxide during the first 3 days of incubation on albumen characteristics, embryonic mortality and hatchability of broiler hatching eggs1

ABSTRACT Three experiments were conducted to determine the effects of increased CO2 concentration during the first 3 d of incubation on albumen height and pH, embryonic mortality, and hatchability of broiler hatching eggs. Hatching eggs were obtained from commercial broiler breeder flocks of Ross 308 at 39 and 37 wk of age in Experiments 1 and 2, respectively. In Experiment 3, eggs were collected at 28 and 35 wk of age. Eggs were incubated under either standard conditions (Control‐CO2) for the entire incubation or increased CO2 concentrations during the first 3 d of incubation (High‐CO2) in 3 experiments. In Experiments 1 and 2, the CO2 concentration was gradually increased from the beginning of incubation onwards to reach 0.80% at 72 h by manual injection of CO2 into airtight laboratory incubators. In the control incubators, the CO2 concentration remained below 0.10% during the same period. Prior to setting, and at 3 d of incubation, the eggs were opened for albumen height and pH measurements in Experiments 1 and 2. In Experiment 3, the eggs were set in commercial incubators. During the first 3 d of incubation, the CO2 concentration was gradually increased to reach 0.70% at 72 h naturally (High‐CO2). In the Control‐CO2 incubator, the CO2 concentration remained below 0.10%. After 3 d, incubation was continued with the control incubator conditions for all eggs from both groups in the 3 experiments. The albumen height was not affected by CO2 treatment, but the treatment significantly decreased albumen pH at 3 d in Experiments 1 and 2 (P < 0.05). A greater CO2 concentration during early incubation reduced fertile hatchability due to increased early embryonic mortality by 2% in the 3 experiments (P ≤ 0.05). The differences in pH might provide one explanation why increased CO2 concentration during early incubation resulted in increased early embryonic mortality. These data indicated that at the beginning of the incubation, ventilation was necessary to prevent increases in CO2 concentration for optimum hatchability results.
Wafer Quality Inspection using Memristive LSTM, ANN, DNN and HTM

The automated wafer inspection and quality control is complex and time consuming task, which can be speed up using neuromorphic memristive architectures, as a separate inspection device or integrating directly into sensors. This paper presents the performance analysis and comparison of different neuromorphic architectures for patterned wafer quality inspection and classification. The application of non-volatile memristive devices in these architectures ensures low power consumption, small on-chip area scalability. We demonstrate that Long-Short Term Memory (LSTM) outperforms other architectures for the same number of training iterations, and has relatively low on-chip area and power consumption.
Catastrophic health spending in Europe: equity and policy implications of different calculation methods

Abstract Objective To investigate the equity and policy implications of different methods to calculate catastrophic health spending. Methods We used routinely collected data from recent household budget surveys in 14 European countries. We calculated the incidence of catastrophic health spending and its distribution across consumption quintiles using four methods. We compared the budget share method, which is used to monitor universal health coverage (UHC) in the sustainable development goals (SDGs), with three other well-established methods: actual food spending; partial normative food spending; and normative spending on food, housing and utilities. Findings Country estimates of the incidence of catastrophic health spending were generally similar using the normative spending on food, housing and utilities method and the budget share method at the 10% threshold of a household’s ability to pay. The former method found that catastrophic spending was concentrated in the poorest quintile in all countries, whereas with the budget share method catastrophic spending was largely experienced by richer households. This is because the threshold for catastrophic health spending in the budget share method is the same for all households, while the other methods generated effective thresholds that varied across households. The normative spending on food, housing and utilities method was the only one that produced an effective threshold that rose smoothly with total household expenditure. Conclusion The budget share method used in the SDGs overestimates financial hardship among rich households and underestimates hardship among poor households. This raises concerns about the ability of the SDG process to generate appropriate guidance for policy on UHC.
Suppression of ABCD2 dysregulates lipid metabolism via dysregulation of miR‐141:ACSL4 in human osteoarthritis

Even though increasing evidence indicates the importance of peroxisomal lipid metabolism in regulating biological and pathological events, its involvement in cartilage development has not been well studied. Here, we identified the importance of peroxisomal function, particularly the functional integrity of ABCD2, in the pathogenesis of osteoarthritis (OA). Knockdown of ABCD2 in OA chondrocytes induced the accumulation of very long chain fatty acids (VLCFAs) and apoptotic cell death. Moreover, knockdown of ABCD2 altered profiles of miRNAs that affect the expression level of ACSL4, a known direct regulator of lipid metabolism. Suppression of ACSL4 in human chondrocytes‐induced VLCFA accumulation, MMP‐13 expression, and apoptotic cell death. In vivo morph‐down of the ACSL4 homologue in zebrafish resulted in significant defects in cartilage development and in vivo knockdown of ACSL4 in cartilage tissue of an OA model mice promoted severe cartilage degradation. In summary, to the best of our knowledge, this is the first report suggesting that the regulatory network among peroxisomal ABCD2:ACSL4:VLCFA serves as a novel regulator of cartilage homeostasis, and these data may provide novel insights into the role of peroxisomal fatty acid metabolism in pathogenesis of human OA.
Use of Clomiphene Citrate in minimal stimulation in vitro fertilization negatively impacts endometrial thickness: an argument for a freeze-all approach

Objective Minimal stimulation IVF is a treatment option that uses clomiphene citrate (CC). We sought to evaluate how CC impacts endometrial thickness during minimal stimulation IVF cycles. Methods We retrospectively analyzed a cohort of 230 cycles in 119 poor ovarian response patients. The IVF cycles were studied in three groups: 130 minimal stimulation cycles, 29 mild stimulation cycles, and 30 conventional high dose gonadotropin releasing hormone (GnRH) antagonist cycles. Thirty-three minimal stimulation IVF patients had 41 frozen embryo transfers (FET) which allowed us to study whether the CC effects were prolonged. Results Endometrial thickness in the minimal stimulation group was significantly lower than the mild and conventional stimulation groups (7.3±2.2mm versus 11.4±3.3mm versus 12.9±3.8mm, respectively, p<0.0001). In patients who underwent minimal stimulation IVF followed by FET, significantly thicker endometrial thickness was achieved during their FET cycles as compared to their minimal stimulation cycles (7.95±2.1mm versus 10.3±1.8mm, p<0.0001). Conclusion We concluded that endometrial thickness is impacted during minimal stimulation IVF cycles. Since negative effects on endometrial thickness are not observed in the patients’ subsequent FET cycle, a freeze-all approach is justified to mitigate adverse endometrial effects of CC in minimal stimulation IVF cycles.
Reducing the Mortality Gap in People With Severe Mental Disorders: The Role of Lifestyle Psychosocial Interventions

This mini-review considers the mortality gap in persons with severe mental disorder (SMD) globally. Current estimates of 10–20 years of potential life lost may be too conservative, both in high (HIC) and low and middle-income countries (LMICs). There is an emerging consensus that natural causes account for the majority of deaths in persons with SMD in both resource settings. In HICs, cardiovascular causes predominate, and can be attributed to individual, health-system and societal level risk factors. Psychosocial lifestyle interventions target behavior specific risk factors for physical ill-health. There is good evidence for tailored weight-loss programmes, but mixed evidence for smoking cessation, substance misuse and risky sexual behavior. In terms of supporting persons with SMD, nurse-led services and the utilization of peer-support are showing promise. Future research efforts must focus on effective interventions and health system models for both high and low resource settings to address this startling health inequality.