Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimating the Market Share and Price Premium of GI Foods—The Case of the Hungarian Food Discounters

The food security of the European Union heavily relies on the food quality systems where Geographical Indications (GI) play an important role. European food is considered world-wide secure and high quality, therefore European food names and designations represent value that should be protected as intellectual property. Despite the importance of GIs in Europe, the availability of the related economic data is very limited, and the only available comprehensive database (in the case of GI foods, the Database of Origin and Registration (DOOR)) details only some very basic and mainly administrative characteristics of such products. From an economic perspective, market size and price premium of these products are the most important in order to assess the economic sustainability of European GI foods. Empirical datasets describing these characteristics of GI products are scarcely available and can be collected only case by case. Therefore, the purpose of this study is to estimate the market size for food products with geographical indications available in Hungary (excluding wines and spirits) and their price premium compared to their direct substitute products, based on empirical data. We conducted monthly mystery shopping for one year (January–December 2018) at three food discount stores (Lidl, Aldi, and Penny Market) operating in Budapest. We collected data on all the GI products available in the stores and their closest substitutes; then the dataset was subsequently analysed and compared to the main characteristics of the DOOR database. The reason for choosing the discounters is that these stores have expanded spectacularly in recent years and are mostly available to average consumers, both in Hungary and across Europe, and based on the main characteristics of this type of retail (limited product portfolio targeting price-sensitive consumers), the data collected here can be considered to indicate the minimum level of market share and price premium. Our results show that currently, GIs have only limited importance in the Hungarian food market, in terms of both the number of products and their market share, as only a small number of such products appear in the food discounters’ supply. As regards the premium achievable with consumer prices, the average price premium is remarkably high (43% on average), even in the case of discounters. Our empirical results also suggest that in Hungary, there is an opportunity to increase the importance of GI foods, both in terms of availability and market share. For Hungarian GI food producers and processors, the level of price premium achievable in discounters might be attractive enough to stimulate their presence in the market.
PLCε knockdown enhances the radiosensitivity of castration-resistant prostate cancer via the AR/PARP1/DNA-PKcs axis

Radiotherapy (RT) has been used as a therapeutic option for treatment of prostate cancer (PCa) for a number of years; however, patients frequently develop RT resistance, particularly in castration-resistant PCa (CRPC), although the underlying mechanisms remain unknown. Understanding the underlying mechanism of RT resistance in CRPC may potentially highlight novel targets to improve therapeutic options for patients with PCa. In the present study, the expression levels of phospholipase Cε (PLCε), androgen receptor (AR) and DNA-dependent protein kinase catalytic subunit (PKcs) were examined in PCa tissue samples and PCa cells, and the effects of PLCε knockdown on AR and DNA damage repair (DDR)-related molecules were determined. The association between PLCε, AR and Poly (ADP-ribose) polymerase 1 (PARP1), as well as their respective roles in radiation resistance, were assessed using gene knockdown and pharmaceutical inhibitors or activators. A chromatin immunoprecipitation assay was used to determine the epigenetic regulatory effects of PLCε on PARP1. Animal experiments were performed to assess whether the mechanisms observed in vitro could be replicated in vivo. The expression levels of PLCε, AR and DNA-PKcs were significantly upregulated in PCa, particularly in CRPC. PLCε knockdown reduced the viability and increased apoptosis of cells subjected to radiation. Additionally, PLCε deficiency suppressed DDR progression by downregulating an AR and PARP1 positive feedback loop and the associated downstream molecules following radiation. PLCε depletion also increased the presence of histone H3 lysine 27 trimethylation in the PARP1 promoter region, suggesting increased methylation of the PARP1 gene and thus resulting in reduced expression of PARP1. In vivo, PLCε knockdown significantly potentiated the effects of radiation on tumor growth. Taken together, the results of the present study demonstrated that PLCε knockdown enhanced the radiosensitivity of CRPC by downregulating the AR/PARP1/DNA-PKcs axis.
Regional variation of non-Hodgkin’s Lymphoma (NHL) in Mongolia and its association with Ki-67 expression

Background: The prevalence of non-Hodgkin’s lymphoma (NHL) varies worldwide in association with demographic and environmental factors. The analysis of these associations in Asia, Africa, and less developed countries is limited by low absolute numbers and unknown etiologic factors such as in Mongolia. The geographic variations in NHL incidence and mortality rates may induce by differences in case ascertainment and registration, or disease diagnosis and classification. The interpretation of NHL patterns and trends remains difficult. Therefore, an attempt was made to test the correlation between Ki-67 expression and clinical parameters on one hand, and geographical or ethnic differences on the other. Research purpose: The objectives of this study are to examine the geographic distribution of non-Hodgkin's disease more in detail for high incidence Mongolian prefectures, and to evaluate the association between the distribution of NHL and Ki-67 expression. Methods: Expression of Ki-67 was examined using an immunohistochemical technique in archival paraffin-embedded sections taken from (n=35) both National pathology center of Mongolia and Etemo clinic previously. Geo-processing was conducted with the aide of the software R Studio [under the Mapping plots] (1.0.136 version). The analyzed geographic incidence rates of NHL include locations of the central and east provinces Orkhon, Uvurhangay, Khuvsgul, Ulaanbaatar and Dornod The age-specific incidence and mortality rates were compared to those for all regions in Mongolia and those for the combined high mortality localities within the high-risk prefectures. Results: Expression of Ki-67 protein was noted in 71.8% of the tumor cases. Average Ki-67 expression was associated with regions of high incidence. Conclusion: We found that provinces with a high incidence and mortality from non-Hodgkin's disease were aggregated in the eastern-central parts of Mongolia, particularly in the areas along Ulaanbaatar capital city.
Correlación entre grupos genéticos y variaciones bioclimáticas en la especie de tortuga continental, Rhinoclemmys melanosterna (Testudines: Geoemydidae)

Colombia has a high diversity of continental chelonians, being a hot spot for this group of vertebrates. However, most species are in some threat category and do not present enough information to assess their real threat status. In this study, potential distribution spaces were estimated for seven genetic lineages of the Rhinoclemmys melanosterna continental tortoise species, with the purpose of generating information to contribute to conservation actions of the same and its habitat. For this, a maximum entropy algorithm and geographic and climatic information are used. The study revealed that several genetic groups of the species have differential abiotic conditions and therefore different areas of distribution. The areas of distribution revealed correspond to some Colombian freshwater ecoregions, suggesting population isolation and limited genetic flow between the genetic groups in each eco region. Additionally, the study suggested the presence of an unidentified genetic clade in the Jurado River. The generated models will be a starting point to propose conservation areas for the different genetic groups, thus preserving their genetic diversity and evolutionary potential in melanosterna Rhinoclemmys.
Coefficient of thermal expansion (CTE) study in metal matrix composite of CuSiC vs AlSiC

Metal matrix composites are widely used as advanced materials for thermal management applications. In view of the demands in higher temperature products application, materials with low coefficient of thermal expansion (CTE) and high thermal conductivity are required. Copper Silicon Carbide (CuSiC) is highly rated as the best materials selected for this application because it has good thermal characteristics especially in CTE, but its density is almost high for high temperature electronic device application. An aluminium silicon carbide (AlSiC) composite, on the other hand, is a new candidate for electronic device application since it has low density and good CTE characteristics. CuSiC and AlSiC composites were fabricated via powder metallurgy method through variety volume fractions such as 5%, 10%, 15% and 20%. In the present study, the comparison of CTE between CuSiC and AlSiC composites with different volume fraction of SiC particles has been carried out. The CTE of CuSiC and AlSiC composites were investigated and their responses between 25°C to 400°C were studied using horizontal dilatometer. Based on the experiment results, the density of CuSiC composites are decrease while the density of AlSiC composites is increase with increasing in SiC particles content. However, the porosity for both composites is increases with increasing in volume fraction of SiC particles. As of CTE, both composites showed decreased with increasing in SiC particles content that dispersed in their matrix. The experimental CTE values for both composites seem to be much lower than theoretical CTE value, which means that there has been excellent bonding between each particle after sintering process. The particles distribution has been observed to understand more on the aspect of SiC particles homogeneity in copper and aluminium matrix.
The Impact of Nursing Interventions on Pediatric Pressure Injuries

The Impact of Nursing Interventions on Pediatric Pressure Injuries by Charleen Deo Singh FNP, University of Phoenix, 2012 MSN, University of Phoenix, 2010 BSN, University of British Columbia, 1997 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Health Services
In vitro activities of the tetrazole SHR8008 compared to itraconazole and fluconazole against Candida and Cryptococcus species

Candida and Cryptococcus are the main pathogens of clinical fungal infection associated with high morbidity and mortality. SHR8008 (in fact, this is the only official name in China and it is called VT-1161 by FDA) is a novel tetrazole agent that selectively inhibits fungal CYP51A compared to mammalian cytochrome P450 enzymes to achieve a better antifungal effect. The in vitro activities of SHR8008 and its comparators itraconazole and fluconazole were determined in 127 Candida and 50 Cryptococcus strains isolated from Chinese patients in the last 2 years by Invasive Fungal Infection Group. The MICs of SHR8008 and other triazoles were measured by the Clinical and Laboratory Standards Institute guidelines M27-E4. For Candida spp. , SHR8008 (geometric mean MIC=0.078 μg/mL) was 6.5-fold and 11.2-fold more potent than itraconazole and fluconazole, respectively. There is a good correlation of MICs between SHR8008 and itraconazole/fluconazole. The MIC values of SHR8008 against Candida glabrata and Candida tropicalis were significantly lower than those of fluconazole, while for Candida albicans and Candida parapsilosis, the differences between SHR8008 and fluconazole were not statistically significant, either. For Cryptococcus spp. , SHR8008 (geometric mean MIC=0.024 μg/mL) was 21.7-fold and 104.5-fold more potent than itraconazole and fluconazole, respectively. Against the seven Cryptococcus neoformans isolates with elevated fluconazole MICs (≥8μg/mL based on the MIC90 value for this azole), SHR8008 maintained potent activity, with MICs ranging between 0.031 and 0.5 μg/mL. The results showed that tetrazole SHR8008 was more promising in the treatment of Candida and Cryptococcus infection than itraconazole and fluconazole.
General practitioner involvement in colorectal cancer survivorship care

Healthcare providers, policy makers and patients have been keen to explore if general practitioners (GPs) could play a larger role in caring for patients with colorectal cancer. Particularly support during the survivorship care after treatment is of interest in this regard. Internationally, GPs have acknowledged the potential benefit primary care can offer colorectal cancer patients, but call for a clearly defined role for GPs and good communication between all care providers. Nationally, Dutch physicians and patients do acknowledge the potential benefit of more primary care involvement, but have also voiced some doubts and reservations. The studies presented in this thesis, combined with other research on this topic published over the last few years, have contributed to more understanding of several aspects of colorectal cancer survivorship care. Patients and health care providers are satisfied with secondary-care-led colorectal cancer survivorship care in the Netherlands, although improvements can be made in addressing psychosocial issues and information provision on several subjects. Although colorectal cancer survivorship care is formally coordinated in a secondary care setting, GPs are already involved in several aspects of survivorship care; ranging from emotional support to first contact for (possible) symptoms of recurrence. Both GPs and patients see the potential benefit of substituting colorectal cancer survivorship care to a primary care setting, and the advantages and obstacles mentioned by both are similar. In general, older patients with comorbid conditions, and patients with lower stages of cancer with less intensive treatment are more inclined to expand the role of the GP in their survivorship care.
Avaliação de Desempenho Profissional: Uma Revisão Sistêmica da Base Scopus de 2008 a 2017

O presente estudo busca analisar o desenvolvimento das publicacoes de artigos cientificos no campo da Avaliacao de Desempenho Profissional, no periodo de 2008 a 2017. Neste sentido, foi realizada uma revisao integrativa nos acervos selecionados na base Scopus , descrevendo estatisticamente os artigos mais relevantes, as referencias mais utilizadas, os autores e periodicos que mais publicaram sobre o tema, a relacao entre os autores, dentre outros. Os resultados demonstram que ha uma significativa influencia de autores americanos e que a psicologia tem papel relevante no desenvolvimento da area de Avaliacao de Desempenho Profissional. Os artigos mais citados refletem esta afirmacao, pois dos dez artigos mais citados, nove foram publicados no periodico Journal of Applied Psychology .
Adaptive motion generation using imitation learning and highly compliant end effector for autonomous cleaning

Recent demographic trends in super aging societies, such as Japan, is leading to severe worker shortage. Service robots can play a promising role to augment human workers for performing various household and assistive tasks. Toilet cleanup is one such challenging task that involves performing complaint motion planning in a constrained toilet setting. In this study, we propose an end-to-end robotic framework to perform various tasks related to toilet cleanup. Our key contributions include the design of a complaint and multipurpose end-effector, an adaptive motion generation algorithm, and an autonomous mobile manipulator capable of garbage detection, garbage disposal and liquid removal. We evaluate the performance of our framework with the competition setting used for toilet cleanup in the Future Convenience Store Challenge at the World Robot Summit 2018. We demonstrate that our proposed framework is capable of successfully completing all the tasks of the competition within the time limit. GRAPHICAL ABSTRACT
Two-sided platforms, heterogeneous tastes, and coordination

This paper studies duopolistic price competition in a two-sided market with positive and negative indirect network externalities on both sides. I develop a model in which the externality is positive for some agents and negative for the others on each side. The paper shows that (i) a platform in equilibrium attracts a larger number of agents on both sides if the proportion of agents who incur a negative externality is small and (ii) each platform in equilibrium obtains a larger market share on one side and a lower market share on the other side if the proportion is large. Social welfare is not maximized in these equilibria because the platform with the lower market share on each side attracts too many agents in the former case while each platform attracts too many agents on the side with a lower market share in the latter case.
Virtuality Changes Consumer Preference: The Effect of Transaction Virtuality as Psychological Distance on Consumer Purchase Behavior

With the rapid development of information and communication technology, a variety of new industries and services are rapidly evolving based on the convergence between existing Information and Communication Technology (ICT) and heterogeneous industries. In the meantime, the FinTech market, created by the convergence of financial and ICT areas, is emerging and growing rapidly. The new market of virtual transaction based on digital money is growing faster than any other FinTech area. The purpose of this study is to determine whether the perceived difference in the virtuality of a consumer’s transaction affects the consumer's purchasing behavior and how the behavior changes. Specifically, this study revealed that consumers' perceived virtuality differs according to the type of transaction method. Consumers felt that the money was more virtual when they had digital (virtual) currency for a service than when they had cash. This virtuality of money controls the psychological distance of the consumer's money, which is closer to cash than virtual currency. This difference in psychological distance affects consumers' information processing, such that when psychological distances are far (vs. close), consumers prefer products that are described as abstract (vs. concrete), and have a more favorable attitude toward products with more variety.
Characteristics of electric quadrupole and magnetic quadrupole coupling in a symmetric silicon structure

Multipole interferences have attracted a lot of interests in last decade due to extraordinary performance on beam control and scattering shaping. However, most of previous works focused on the dipole-based interferences while the quadrupole modes and other high-order multipole modes with unique properties were of less attention. In this work, we aim to expand the present dipole-based multipole-interference regime to the quadrupole-interference regime. We study the interference between an electric quadrupole (EQ) and a magnetic quadrupole (MQ) in both isolated and periodically arranged homogeneous cross dielectric structure. Through structural parametric control, the EQ and MQ can be precisely tuned to share the same resonant intensity at a specific wavelength, resulting in a generalized Kerker effect. Moreover, a dark MQ mode, which is orthogonal with the original MQ mode, arises when we increase the interaction between structure. We find that the spectral approaching between dark MQ and original bright EQ results in an EIT effect and Fano-shaped spectral reflection response. The induced Fano spectrum possesses tunable quality factors varying from ∼10 to >105 with the variation of EQ–MQ coupling efficiency. The numerically derived maximum quality factor (238, 618) of the dielectric EQ–MQ coupling system even exceeds the quality factors of many plasmonic resonant systems. We also prove that such spectrum can be adopted to refractive index sensing. Besides, we show that EQ–MQ coupling can bring about rapid 2π phase change, which can be applied in metasurface designs. These results and conclusions about the EQ–MQ interference systems can provide a promising avenue for advanced optical devices.
Contrast sensitivity before and after small incision lenticule extraction and femtosecond laser in situ keratomileusis

Introduction: Contrast sensitivity function after laser ablation of the cornea in refractive surgery is an important tool for measuring quality of visual function. The effect of small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK) on visual function can be compared by measuring spatial contrast sensitivity. Purpose: This study was to compare contrast sensitivity function in patients undergoing refractive surgery for myopia at Tilganga Institute of Ophthalmology. Methods: In a retrospective study, 15 subjects who underwent refractive surgeries comprising 9 cases of SMILE and 6 cases of FS-LASIK at Tilganga Eye Hospital were enrolled in the study. A major assessment included best corrected monocular contrast sensitivity with functional vision analyzer at spatial frequencies of 1.5, 3, 6, 12, and 18 cycles/deg in photopic condition (85 cd/m2) before, 3 months, and 1 year after the surgery. The average functional acuity contrast test scores for each spatial frequency were recorded. Differences between preoperative and postoperative contrast sensitivity at each spatial frequency were analyzed through parametric paired Student’s t-test. Results: Contrast sensitivity of postoperative FS-LASIK and SMILE did not differ from preoperative values at a photopic level. However, at high spatial frequency (12 and 18 cycles/deg), contrast sensitivity function improved significantly (p < 0.05) in eyes after FS-LASIK. Eyes after SMILE surgery did not show any reduction in contrast sensitivity at all the spatial frequencies. Conclusion: Under photopic conditions, the contrast sensitivity function is unaffected by SMILE or FS-LASIK.
Antiproliferative, Antimicrobial, and Antifungal Activities of Polyphenol Extracts from Ferocactus Species

Polyphenols, obtained from natural resources, may possess important pharmacological effects. The polyphenolic profiles of the stem extracts of six Ferocactus species (sp.): F. gracilis, F. pottsii, F. herrerae, F. horridus, F. glaucescens, and F. emoryi, were measured using high-performance liquid chromatography (HPLC) with diode-array detection (DAD). Additionally, anticancer, antibacterial, and antifungal activities were examined. Results showed the presence of high to moderate amounts of polyphenols in the extracts (phenolic acids: Protocatechuic acid, 3,4-dihydroxyphenylacetic acid, caffeic acid, and vanillic acid; flavonoids: Rutoside and quercitrin). The highest amounts of 3,4-dihydroxyphenylacetic acid were found in F. glaucescens ((132.09 mg 100 g−1 dry weight (DW)), F. pottsii (75.71 mg 100 g−1 DW), and F. emoryi (69.14 mg 100 g−1 DW) while rutoside content was highest in F. glaucescens (107.66 mg 100 g−1 DW). Maximum antiproliferative activities were observed against HeLa and Jurkat cancer cells, with F. glaucescens, F. emoryi, and F. pottsii showing the highest anticancer activity. Most bacteria were sensitive to Ferocactus sp. stem extracts. Escherichia coli and Staphylococcus aureus were the most sensitive. Excellent antifungal effects were observed against Aspergillus ochraceus and A. niger. However, Penicillium funiculosum, P. ochrochloron, and Candida albicans were relatively resistant. This is the first study reporting novel sources of polyphenols in Ferocactus sp. with anticancer and antimicrobial activities.