Miracle-dz/UniFAR-FTUs huggingface dataset:
Inter-relationship of articular cartilage thickness and cellularity.

DR. G. D. KERSLEY (Bath) The first controlled trial of radiotherapy in arthritis was performed in Bath by Max Desmarais. Rheumatoid subjects, osteoarthritics, and spondylitics were treated and the controls in each group were put under the machine but the current was not turned on. They were assessed at 3 and 6 months. In general, radiotherapy was found to be of no value in rheumatoid arthritis, but in ankylosing spondylitis it was of dramatic benefit, and in osteoarthrosis there was a significant improvement.
Editorial Notes - The Growth of Interest in Services Management: Opportunities for Information Systems Scholars

Across the global economy, we are witnessing a dramatic transformation toward a services economy. At the same time, advances in information technologies provide significant opportunities for digitization of services and the development of services management thinking within the information systems community. This note aims to stimulate attention toward the promising research and teaching opportunities for information systems scholars in the domain of digitized services innovation, management, and use.
Bimaxillary Osteotomy Using a Physiological Positioning Strategy for Skeletal Class II with Anterior Open Bite and Gummy Smile: Case Reports and Review of the Literature

The treatment of skeletal class II cases has long been a great challenge because of the tendency for relapse. This is particularly true in skeletal class II patient with an anterior open bite and gummy smile, owing to the anterior movement and counter-clockwise rotation of the mandible. This movement of the mandible sometimes induces relapse and temporomandibular disorders. To avoid these complications, we have advocated a new treatment strategy, the ‘physiological positioning strategy’, for mandibular osteotomy in patients with jaw deformity. Few disadvantages were observed after surgery when using this strategy, and good outcomes were seen in skeletal class III patients who underwent bimaxillary osteotomy or mandibular osteotomy solely. Two skeletal class II patients with anterior open bite and a gummy smile were treated using this method. The long-term outcomes were good in both cases. The proximal segments moved anteriorly after surgery. This new treatment strategy may provide a reliable outcome for not only class III but also class II cases, even when concomitant anterior open bite and a gummy smile are present.
Diagnostic evaluation and survival analysis of colorectal cancer patients with liver metastases

Clinical features and their prognostic value were evaluated in 83 colorectal cancer patients with liver metastasis. The clinical features analysed included presenting symptoms and signs, liver function tests, extent of liver involvement, associated extrahepatic tumor growth, and physical condition of the patients. Overall median survival time after diagnosis of liver metastases was 8.4 months. Prognostic factors related to survival were symptoms, when referable to liver metastasis, and 5′ Nt. Information is supplied to survey what selection of patients should be considered for various treatment options. A predominance of the patients showed bilobar liver involvement (79.6%), extrahepatic tumor growth (49.4%), or had an unresectable primary tumor (30.1%), thus leaving only 6% of the patients with liver metastases for surgical treatment with the intention of cure.
Ladder approximation for spontaneous chiral-symmetry breaking.

This paper examines the validity of the ladder approximation in gauge theories such as technicolor theories in which the coupling is a slowly running function of momentum and is large enough to trigger spontaneous chiral-symmetry breaking. We find that the next-higher-order terms beyond the ladder approximation amount to only a 1%--20% correction, depending on the fermion representation. This indicates that the ladder expansion may provide a much better description of chiral-symmetry breaking than previously thought.
Discrete time sliding mode control for satellite clusters at Lagrange points

This paper presents a discrete time sliding mode control system based upon a discrete reaching rate law and applied to an autonomous 6DoF satellite cluster located at the interior Sun-Earth Lagrange point. Centralized decision processes with distributed action are used to enable cluster dispersal from a central spacecraft and reconfiguration to optimally form an interferometer array dependant upon the number of cluster members, whilst considering collision avoidance.
Search behaviour in electronic document and records management systems: an exploratory investigation and model

Introduction. Organisations implement records management programmes and invest in electronic document and records management systems so that information can be accessed by the right person, at the right time, with the least amount of effort and cost. One of the key factors that predicts the effectiveness of these systems relates to the degree to which users successfully identify the records they wish to retrieve. In this paper we offer a deeper insight into how knowledge workers employ these systems to address their information needs. Method. Four records managers were interviewed to determine how records management principles were applied in their systems. Interviews were also conducted with ten users from each organisation to map their search behaviour. Additionally, protocol analysis was used to observe how participants verbalised their thought processes and actions when they conducted their simple and difficult searches in the systems. Results. A comprehensive model of search behaviour when using electronic document and records management systems was developed from the study. Seven key search stages were identified, illustrating the different ways in which searchers approach their information problem. Conclusions. The study highlights some key differences between users of these systems and other forms of information search behaviour, including different Page 1 of 31 Search behaviour in electronic document and records management systems: an explor. 3/04/2014 http://www.informationr. net/ir/18-1/paper572.html methods of addressing simple or difficult search needs, and user approaches around identifying search strategies. The particular challenges that arise in retrieving information from these systems are also explored.
"Willful misconduct": how the US government prevented tobacco-disabled veterans from obtaining disability pensions.

In this descriptive case study, we analyze the unsuccessful struggle to access disability pensions by veterans sickened by tobacco use begun during service. Drawing on tobacco industry documents and other material, we show how the US government, tobacco industry, and veterans' organizations each took inconsistent positions to protect their interests. Congress and Department of Veterans Affairs leadership, concerned about costs, characterized veterans' smoking as "willful misconduct," thereby contradicting the government's position in a federal lawsuit that tobacco companies addicted smokers. Veterans' groups supported the pensions, despite previously defending smoking as a "right. " The tobacco industry wavered, fearing liability. Securing pensions was complicated by the notion that smoking is primarily a personal choice. The US government should compensate veterans fairly and should abolish military practices that encourage tobacco addiction.
Crisis in a Foreign Language: Emergency Services and Limited English Populations

Social media are increasingly used by emergency responders as part of the communication infrastructure during crisis. As such, it is important to understand how these new technologies offer opportunities and barriers to information access for population affected during crisis events. In particular, this project explores the extent to which Twitter is used to provide emergency-related information to vulnerable populations both during routine and crisis contexts. We look longitudinally, across four years, at the online information and communication behaviors of official emergency responders in the United States. Our results demonstrate a notable lack of crosslanguage crisis communication on social media. We discuss the practical implications of these results, and offer directions for future work and improvement of practices.
Investigational epigenetically targeted drugs in early phase trials for the treatment of haematological malignancies

Introduction: For decades, cancer research has focussed on the genetic defects that drive tumourigenesis. However, recent high-resolution sequencing studies have uncovered mounting evidence for the complementary role of epigenetic deregulation as a hallmark of haematological malignancies. The reversibility of epigenetic changes makes them suitable candidates for pharmacological manipulation and therapeutic targeting. Areas covered: This review summarises the mechanisms of normal epigenetic regulation and how these are perturbed in haematological malignancies as a result of genetic alterations. The article concludes with how these can be reversed and appraises the investigational epigenetically targeted therapies in preclinical and clinical use. Expert opinion: The identification of recurring alterations in components of the epigenome of leukaemia and lymphoma has driven the rapid development of highly potent epigenetically targeted therapies. This rapid development has alluded to the possibility of a personalised therapeutic approach in selected patient populations. An enhanced understanding of the biological effects of these epigenetic alterations in initiation and progression of haematological malignancies, together with a clear mechanistic insight into how the drugs reverse the phenotypes, will define their translation into routine clinical use.
Treatment Results of Pediatric Osteosarcoma: Twenty-Year Experience

The objectives of the study were to compare the results of surgical procedures, amputation and limb-sparing surgery, and to assess the influence of preoperative chemotherapeutic regimens on the survival of pediatric patients with osteosarcoma. We retrospectively analyzed 69 patients treated at our institution between January 1985 and April 2004. The primary treatment modalities were limb-sparing surgery or amputation with or without preoperative chemotherapy. The need for postoperative chemotherapy was determined by the histological response, the tumor margins, and the burdens created by the metastatic disease. The age range was 5.3 to 18.6 years (median, 13.3 years); with a male-female ratio of 0.9. The most common lesion site was the femur, found in 39 patients. Fourteen of the patients had metastases involving the lungs or other bones at the time of diagnosis. Preoperative chemotherapy was done in 45 patients. Most of the patients were treated with cisplatin + adriamycin (27/69, 39.1%). Forty-two patients were surgically treated by amputation and 19 with limb-sparing surgery. Four patients had surgical resection of masses located at sites other than the extremities, and in 4 patients, surgery was not possible. The overall survival rate for the whole group was 32.6%. The overall survival rates were 27.2% and 66.9% for the patients treated with amputation and limb-sparing surgery, respectively. Osteosarcoma has a poor prognosis. Based on our 20-year experience, limb-sparing surgery as surgical management and the cisplatin + adriamycin preoperative chemotherapy regimen seem to be a promising modality for the patients with osteosarcoma.
Determining the orientations of ocean bottom seismometers using ambient noise correlation

The cross‐correlation of multicomponent ambient seismic noise can reveal both the velocity and polarization of surface waves propagating between pairs of stations. We explore this property to develop a novel method for determining the horizontal orientation of ocean bottom seismometers (OBS) by analyzing the polarization of Rayleigh waves retrieved from ambient noise cross‐correlation. We demonstrate that the sensor orientations can be estimated through maximizing the correlation between the radial‐vertical component and the phase‐shifted vertical‐vertical component of the empirical Green's tensor. We apply this new method to the ELSC (Eastern Lau Spreading Center) OBS experiment data set and illustrate its robustness by comparing the obtained orientations with results from a conventional method utilizing teleseismic P and Rayleigh wave polarizations. When applied to a large OBS array, the ambient noise method provides a larger number of orientation estimates and better azimuthal coverage than typically is possible with traditional methods.
Age‐Adjusted Exact Trend Tests in the Event of Rare Occurrences

Summary. Preclinical animal carcinogenicity studies are usually concerned with testing the statistical significance of a dose–response relationship. When the response consists of a rare event such as the development of a certain type of tumor, exact statistical methods are often employed. The exact randomization trend test based on the multivariate hypergeometric distribution is less powerful in the presence of treatment‐related risks other than the specified response. Particularly, the loss of power becomes more pronounced when competing risks cause progressively higher mortality rates with increasing dose, which is usual in practice. An age‐adjusted form of the randomization test is proposed to adjust for this effect. Permutational distribution for Peto's cause‐of‐death (COD) test is also explored and compared with its asymptotic counterpart by simulation. The use of COD information has been a controversial issue due to the subjectivity in the pathologists' determinations as well as for economic reasons. The proposed age‐adjusted exact test does not require COD, and it is shown to compare favorably to the COD tests via an extensive Monte Carlo simulation. Applications of the methods to two real data sets are included.
Surface EMG crosstalk during phasic involuntary muscle activation in the nociceptive withdrawal reflex

The human nociceptive withdrawal reflex is typically assessed using surface electromyography (sEMG). Based on sEMG, the reflex receptive field (RRF) can be mapped. However, EMG crosstalk can cause erroneous results in the RRF determination. Single differential (SD) vs. double differential (DD) surface EMG were evaluated. Different electrode areas and inter‐electrode‐distances (IED) were evaluated. The reflexes were elicited by electrical stimulation of the sole of the foot. EMG was obtained from both tibialis anterior (TA) and soleus (SOL) using both surface and intramuscular EMG (iEMG). The amount of crosstalk was significantly higher in SD recordings than in DD recordings (P < 0.05). Crosstalk increased when electrode measuring area increased (P < 0.05) and when IED increased (P < 0.05). Reflex detection sensitivity decreases with increasing measuring area and increasing IED. These results stress that for determination of RRF and similar tasks, DD recordings should be applied. Muscle Nerve 46: 228–236, 2012
The Design and Implementation of a Mobile Phone Detector Device with a Frequency Jamming Feature

The development of ways to reduce malpractices in examination centers in all educational institutions is an important area of research. One of the major problems discovered aiding malpractices has been the creation of mobile phones, which however is a good communication device but needs to be curtailed during examinations. In order to have a 100% assurance that no student can cheat with his or her mobile phone a mobile detector system with a frequency jamming feature was developed using mobile cell phone detection techniques of measuring a cell phone's electromagnetic properties, determining an identifiable signature, measuring the RF spectrum and meeting the jamming requirements.
Absolute number of circulatory sézary cells.

To the Editor. — Recent studies have demonstrated that Sezary cells are found in the circulation of normal persons 1 and of patients with various inflammatory dermatoses 2 and are not always found in the blood of patients with cutaneous T-cell lymphoproliferative disease. 3 The demonstration of the cyclic nature of the presence of Sezary cells in the peripheral blood of patients with the Sezary syndrome has increased interest in the quantitation of Sezary cells. 4 Expressing Sezary cells as a percentage of WBCs counted can give an erroneous impression. The Figure shows that the patient we observed had more than 15% Sezary cells in September and October 1979 and had cycles of cell values that peaked at more than 35% (Figure, left). When expressed as an absolute number of Sezary cells in relation to the total number of circulating WBCs, greatly different numbers were obtained (Figure, right). Cycles of Sezary
[Hemolysis produced by Candida tropicalis isolates from clinical samples].

INTRODUCTION Yeasts belonging to the genus Candida are responsible for the majority of fungal infections in humans. Candida tropicalis has been one of most commonly isolated non-albicans species. To analyze in vitro hemolysis promoted by clinical isolates of C. tropicalis obtained from blood and other clinical samples from hospitalized patients at the University Hospital of Londrina State University, Paraná, Brazil. METHODS The hemolysis promoted by 28 clinical isolates of C. tropicalis was evaluated, and the isolates were grouped into classes according to the hemolysis levels. RESULTS The majority of the blood isolates showed weak hemolysis (+), while the classes of strong hemolysis (+++) and very strong hemolysis (++++) predominated among isolates from other clinical samples such as urine, nail lesions and tracheal secretions. However, no statistical differences were detected (p> 0.05). CONCLUSIONS Isolates of C. tropicalis obtained from different clinical samples showed a capacity to promote in vitro hemolysis.
Local mechanical-stress control (LMC): a new technique for CMOS-performance enhancement

We have developed a new technique, called "local mechanical-stress control" (LMC), to enhance CMOS current drivability. It utilizes high mechanical stress produced by a SiN layer and Ge-ion implantation to selectively relax the stress of the layer. The drive currents of both n- and p-MOSFETs can be improved by controlling the stress of the SiN layer selectively. The effects of LMC become more significant as devices become smaller, and the drive current is estimated to increase by more than 20% in future 70-nm CMOS technology.
PERCEIVED MATCH BETWEEN VISUAL PARAMETERS AND AUDITORY CORRELATES: AN EXPERIMENTAL MULTIMEDIA INVESTIGATION

This paper investigates the relationship between the auditory and visual components of an audio-visual (A-V) composite. Participants (N=28) were asked to rate the perceived degree of “match” between A-V components in a series of randomly presented composites. Manipulated audio parameters included pitch, loudness, timbre, and duration, while visual parameters included color, vertical location, shape, and size. A-V composites were created by combining all possible pairs of audio and visual stimuli using three different magnitudes of change, resulting in 48 A-V stimuli, i.e., 4 x 4 x 3. Data analysis revealed no statistically significant between-subjects differences as a result of either level of musical training or level of visual training. There was, however, a significant within-subjects difference in responses to the audio-visual pairs. Subject mean response ratings suggest the following primary relationships: pitch with vertical location, loudness with size, and timbre with shape. Duration did not pair as “best match” with any visual parameter. Results also revealed that color is equally matched with both pitch and loudness. The long-term goal of this project is to utilize the results of the music perception study reported as a basis for developing an algorithm to transform musical sound into visual animation, based on perceptually salient properties. 1. BACKGROUND Many multimedia software programs are currently available that provide listeners with a visual analog to musical sound (e.g., Windows Media Player, iTunes, WinAmp, Sonique, etc.). However, the specific manner in which – as well as the basis for – transformation of the sonic component into a visual analog is rarely given much consideration. Though the most frequently used algorithm involves calculation of a fast Fourier transform of the complex audio signal and the mapping of these data onto screen coordinates, email communication with developers who created many of these programs reveals that the selection of visual parameters – color, shape, and motion – altered in association with various aspects of the musical sound – frequency, amplitude, and timbre – tends to be arbitrary. The present investigation sought to identify the degree of match between specific aspects of musical sound and those of animated visual images. The long-term goal of this project is to utilize the results of the music perception study reported herein as a basis for developing an algorithm to transform musical sound into visual animation that is based on perceptually salient properties.
A Novel Non-Pharmaceutical Treatment for Patients with Mild Cognitive Impairment

Mild cognitive impairment (MCI) represents a pre-dementia stage. Currently, there is no evidence for long-term efficacy of pharmacological treatment for preventing conversion to clinical dementia. Healthy lifestyle modifications, cognitive training and psychosocial initiatives are strongly recommended. This was an 8-week parallel randomized two-armed study. Eligible patients were randomized to intervention and control group, with the intervention group receiving the PSAI intervention including cognitive training, healthy lifestyle and stress management. Standardized questionnaires were used pre- and post-intervention. The between group analysis revealed a significant improvement in cognitive aspects, depression, stress, anxiety and self-efficacy post-intervention (p 0.5). Nine patients in the intervention group had one point increase in the MMSE score and one patient had a two-point increment post-intervention. Future studies should expand these preliminary findings to larger samples, neuroimaging measurements and longer follow-up in order to ascertain PSAI’s role in preventing conversion to clinical dementia.
Text-Mining Approach for Evaluation of Affective Management Practices

— The purpose of this paper is to propose a text mining approach to evaluate companies’ practices on affective management. Affective management argues that it is critical to take stakeholders’ affects into consideration during decision-making process, along with the traditional numerical and rational indices. CSR reports published by companies were collected as source information. Indices were proposed based on the frequency and collocation of words relevant to affective management concept using text mining approach to analyze the text information of CSR reports. In addition, the relationships between the results obtained using proposed indices and traditional indicators of business performance were investigated using correlation analysis. Those correlations were also compared between manufacturing and non-manufacturing companies. The results of this study revealed the possibility to evaluate affective management practices of companies based on publicly available text documents.
Hydrodynamic theory of active matter

We review the general hydrodynamic theory of active soft materials that is motivated in particular by biological matter. We present basic concepts of irreversible thermodynamics of spatially extended multicomponent active systems. Starting from the rate of entropy production, we identify conjugate thermodynamic fluxes and forces and present generic constitutive equations of polar active fluids and active gels. We also discuss angular momentum conservation which plays a role in the the physics of active chiral gels. The irreversible thermodynamics of active gels provides a general framework to discuss the physics that underlies a wide variety of biological processes in cells and in multicellular tissues.