Miracle-dz/UniFAR-FTUs huggingface dataset:
Disability and Psychiatric Symptoms in Men Referred for Treatment with Work-Related Problems to Primary Mental Health Care

The relationship between male sex and employment as barriers to accessing mental health care is unclear. The aim of this research was to examine (1) whether the clinical features of men referred to a shared mental health care (SMHC) service through primary care differed when symptoms were affecting them in the work domain; and (2) empirically re-evaluate the effectiveness of a SMHC model for work-related disability using a pre-post chart review of N = 3960 referrals to SMHC. ANOVA and logistic regression were performed to examine symptoms (Patient Health Questionnaire, PHQ) and disability (World Health Organization Disability Assessment Schedule, WHODAS 2) at entry and discharge. Men were RR (relative risk) = 1.8 (95% C.I.: 1.60–2.05) times more likely to be referred to SMHC with work problems than women. Having greater disability and more severe somatic symptoms increased the likelihood of a work-related referral. There were no significant differences after treatment. Problems in the work domain may play an important role in men’s treatment seeking and clinicians’ recognition of a mental health care need. This study is relevant because men are underrepresented in mental health (MH) treatment and primary care is the main gateway to accessing MH care. Asking men about functioning in the work domain may increase access to helpful psychiatric services.
Distinguishing between water column and sedimentary denitrification in the Santa Barbara Basin using the stable isotopes of nitrate

Below its sill depth, the Santa Barbara Basin (SBB) is commonly suboxic ([O2] ∼ 3 μM), with only brief periods of ventilation. Associated with development of suboxia, the concentration of nitrate decreases with depth into the basin without an associated decrease in phosphate, indicating that a substantial fraction of the nitrate supplied to the basin is removed by denitrification. Coincident with the decrease in nitrate concentration across the “redoxcline” (the interface between oxic and suboxic waters) within the SBB, there is an increase in the 15N/14N of that nitrate, as would be anticipated from the isotopic fractionation associated with denitrification. However, the increase in 15N/14N of nitrate is much smaller than occurs in the open eastern tropical North Pacific (ETNP) for a comparable amount of nitrate loss. Both the concentrations of N species within the basin and measurements of nitrate 18O/16O suggest that the lower‐than‐expected 15N enrichment in the suboxic SBB involves denitrification, rather than being due to some unknown source of low‐15N/14N N to the deep SBB. Calculations with a range of models of nitrate supply and consumption indicate that the degree of nitrate consumption in the basin is too small for differences in water circulation to explain the isotopic differences between the Santa Barbara Basin and the open ETNP. Previous studies indicate that the isotope effect of sedimentary denitrification is negligible due to nitrate diffusion in sediment pore waters. Thus we infer that the small magnitude of the isotopic enrichment of SBB water column nitrate is due to the importance of sedimentary denitrification within the basin. Assuming that water column and sedimentary denitrification have isotope effects of 25 and 1.5 per mil, respectively, our results suggest that sedimentary denitrification accounts for more than 75% of the nitrate loss within the suboxic SBB.
Clustering-based co-tier interference coordination in dense small cell networks

Along with the exponential growth of mobile data traffic over the past few years, dense small cell networks are considered an attractive solution to cope with the mobile traffic demand. However, users of small cells in dense environment are exposed to serious co-tier interference problem and users at the edge of small cells have worse performance especially. In order to improve the performance of redefined edge users and maintain the throughput of the network, we propose a clustering-based co-tier interference coordination (CCIC) scheme on the downlink (DL) side to mitigate co-tier interference to edge users. Firstly, small cells are clustered based on the graph coloring algorithm (GCA). Secondly, we schedule frequency resources into two bands as well as group users into two categories. Different kinds of bands are assigned to corresponding users. Accordingly we reduce power on a band defined as center band to mitigate interference to edge users. Then a utility function is proposed to find the optimal transmission power of each small cell base station (SBS) on center band. Finally, differential evolution (DE) algorithm is applied to obtain the optimal transmission power. System level simulation results show that our proposed scheme can greatly improve the edge user throughput with slightly sacrificing the overall throughput. Meanwhile, it can improve the network energy efficiency (EE) dramatically.
Relativistic all-order many-body calculations of the n=1 and n=2 states of heliumlike ions.

An all-order procedure is used to determine the energies of the n=1 and n=2 states of heliumlike ions with nuclear charges in the range Z=3--100. The Coulomb energies and wave functions are obtained from a no-pair Hamiltonian by an iterative scheme that sums all orders of many-body perturbation theory. The Breit energy is determined by taking the expectation value of the instantaneous Breit Hamiltonian between the Coulomb wave functions. Corrections for the frequency dependence of the Breit interaction and for two Breit interactions are included. Quantum-electrodynamic and mass-polarization corrections are taken from Drake's unified method [Can. J. Phys. 66, 586 (1988)]. The resulting energies are complete through order (Z\ensuremath{\alpha}${)}^{3}$ a.u. and include new terms of order (Z\ensuremath{\alpha}${)}^{4}$ a.u. Comparisons are made with experiment and with recent configuration-interaction calculations.
An EMG analysis of the shoulder in throwing and pitching

Five male subjects' throwing and pitching motions were analyzed by dynamic electromyography and high speed photography. Electrodes inserted into the deltoid and rotator cuff muscles attempted to define muscle activation patterns during the throwing and pitching cycle. The wind-up or preparation (Stage I) had no consistent pattern. Cocking (Stage II) had a sequential muscle activation pattern of first deltoid activity, followed by the S.I. T. muscles and finally by the subscapularis muscle. Acceleration (Stage III) had a lack of muscle activity, even though the arm was accelerating forward in space. Follow-through (Stage IV) was the most active stage with all the muscles firing intensely. The muscle patterns observed during the cycle were largely characteristic of attempts to decelerate the arm.
Evaluation of Piperonyl Butoxide as a Deltamethrin Synergist for Pyrethroid-Resistant Bed Bugs

ABSTRACT An understanding of the mechanisms of insecticide resistance in the bed bug, Cimex lectularius L. , has the potential to lead to new approaches for the control of resistant populations. We used the cytochrome P450 monooxygenase (P450) inhibitor piperonyl butoxide (PBO) to assess the role of P450s in deltamethrin resistance in three field-collected bed bug strains, LA-1, CIN-1 and WOR-1. In addition, we exposed two highly resistant strains, CIN-1 and WOR-1 (resistance ratio [RR] >2,500-fold), to dry residues of piperonyl butoxide-synergized pyrethroid formulations to determine the utility of synergism by PBO. Piperonyl butoxide synergized deltamethrin in all three strains, but its impact was variable. The synergistic ratio varied from 40 in CIN-1 to 176 in WOR-1. Because the resistance ratio for each strain after piperonyl butoxide treatment was 174 and 39, respectively, our results suggest that P450s have some involvement in deltamethrin resistance, but other resistance mechanisms must be involved as well. No significant synergistic effect of formulated deltamethrin was observed with the addition of synergized Pyrethrins or formulated piperonyl butoxide in the CIN-1 strain, but synergism occurred in the WOR-1 strain. Addition of PBO to pyrethroids is not a comprehensive solution to pyrethroid resistance because strains vary in both overall resistance level and the proportion of that resistance attributable to P450s.
Frictional adhesion: a new angle on gecko attachment

SUMMARY Directional arrays of branched microscopic setae constitute a dry adhesive on the toes of pad-bearing geckos, nature's supreme climbers. Geckos are easily and rapidly able to detach their toes as they climb. There are two known mechanisms of detachment: (1) on the microscale, the seta detaches when the shaft reaches a critical angle with the substrate, and (2) on the macroscale, geckos hyperextend their toes, apparently peeling like tape. This raises the question of how geckos prevent detachment while inverted on the ceiling, where body weight should cause toes to peel and setal angles to increase. Geckos use opposing feet and toes while inverted, possibly to maintain shear forces that prevent detachment of setae or peeling of toes. If detachment occurs by macroscale peeling of toes, the peel angle should monotonically decrease with applied force. In contrast, if adhesive force is limited by microscale detachment of setae at a critical angle, the toe detachment angle should be independent of applied force. We tested the hypothesis that adhesion is increased by shear force in isolated setal arrays and live gecko toes. We also tested the corollary hypotheses that (1) adhesion in toes and arrays is limited as on the microscale by a critical angle, or (2) on the macroscale by adhesive strength as predicted for adhesive tapes. We found that adhesion depended directly on shear force, and was independent of detachment angle. Therefore we reject the hypothesis that gecko toes peel like tape. The linear relation between adhesion and shear force is consistent with a critical angle of release in live gecko toes and isolated setal arrays, and also with our prior observations of single setae. We introduced a new model, frictional adhesion, for gecko pad attachment and compared it to existing models of adhesive contacts. In an analysis of clinging stability of a gecko on an inclined plane each adhesive model predicted a different force control strategy. The frictional adhesion model provides an explanation for the very low detachment forces observed in climbing geckos that does not depend on toe peeling.
Meaningful end points and outcomes in men on active surveillance for early-stage prostate cancer

Purpose of review Active surveillance is a management strategy for early-stage prostate cancer designed to balance early detection of aggressive disease and overtreatment of indolent disease. We evaluate recently reported outcomes and discuss the potentially most important endpoints for such an approach. Recent findings The past 2 years have seen the publication of two trials of watchful waiting versus immediate treatment and updates of multiple active surveillance cohorts for men with early-stage prostate cancer. The watchful waiting trials demonstrated a small potential mortality benefit to immediate treatment when applied to all risk levels (6% absolute difference at 15 years), emphasizing the importance of a risk-adapted strategy. In reported active surveillance cohorts, prostate cancer death and metastasis remain rare events. Intermediate outcomes such as progression to treatment and upgrading/upstaging on final disease appear consistent among cohorts, but must be interpreted with caution when compared with historical controls of immediate treatment because of potential selection bias. Summary The safety of active surveillance has been reinforced by recent reports. Accumulation of additional data on men with intermediate risk cancer and development and validation of new biomarkers of risk will allow refined and, likely, expanded use of this approach.
COMPROMETIMENTO PULMONAR E FUNCIONAL DOS PACIENTES PORTADORES DE DPOC ENCAMINHADOS AO AMBULATÓRIO DE FISIOTERAPIA CARDIO PULMONAR DA UNIVERSIDADE PARANAENSE

O objetivo deste estudo foi identificar o grau de comprometimento pulmonar e funcional dos pacientes portadores de doenca pulmonar obstrutiva cronica (DPOC), encaminhados ao Ambulatorio de Fisioterapia Cardio Pulmonar da Universidade Paranaense (UNIPAR). Foram avaliados 24 individuos sendo, 12 portadores de DPOC grau (leve, moderado e grave) e 12 individuos saudaveis. Todos os participantes foram submetidos a avaliacao antropometrica, ao teste de funcao pulmonar, ao teste da capacidade de exercicio, avaliacao da dispneia e da mobilidade toracica e foram previamente esclarecidos sobre o objetivo e delineamento do estudo. Em relacao as caracteristicas antropometricas foi verificado que o indice de massa corporea foi igual entre os grupos estudados, mesmo apresentando diferenca em relacao a idade. A funcao pulmonar dos grupos estudados foi estatisticamente diferente em relacao ao grupo saudavel. Os pacientes portadores de DPOC apresentaram um deficit de 53,09% em relacao a CVF; 58,05% em relacao ao VEF1; 58,19% em relacao a VVM quando comparado ao grupo saudavel. O grupo DPOC apresentou um deficit de 18,67% na capacidade de exercicio submaxima avaliada pelo teste da DP6min. Em relacao ao grau de dispneia, que foi mensurado por intermedio da escala de Borg, verificou-se que o grupo DOPC apresentou mais comprometimento desse parâmetro, tanto no repouso quanto apos o exercicio em relacao a grupo de individuos saudaveis. Os pacientes portadores de DPOC atendidos no Ambulatorio de Fisioterapia Cardio Pulmonar da UNIPAR apresentam deficits medio de 50% na condicao pulmonar, 18% na capacidade de exercicio e um comprometimento importante da dispneia apos um esforco submaximo.
Regulation of life and death by the zinc finger transcription factor Egr‐1

The biosynthesis of the zinc finger transcription factor Egr‐1 is stimulated by many extracellular signaling molecules including hormones, neurotransmitters, growth and differentiation factors, and cytotoxic metabolites. The 5′‐flanking region of the Egr‐1 gene contains genetic elements that are essential in connecting stimulation of the cells with enhanced transcription of the Egr‐1 gene, and subsequently, transcription of Egr‐1‐responsive genes. Thus, Egr‐1 links cellular signaling cascades with changes in the gene expression pattern. Many biological functions have been attributed to Egr‐1. Here, we discuss evidence for Egr‐1 control of cellular proliferation and programmed cell death. J. Cell. Physiol. 193: 287–292, 2002. © 2002 Wiley‐Liss, Inc.
Drinking Patterns and Alcohol-Related Birth Defects

The consequences of maternal alcohol use during pregnancy on the outcome of offspring depend, among other factors, on the amount and pattern of alcohol consumption. Animal studies found that bingelike drinking patterns, in which the fetus is exposed to high blood alcohol concentrations (BACs) over relatively short periods of time, are particularly harmful, even if the overall alcohol amount consumed is less than those of more continuous drinking patterns. Long-term studies in humans have confirmed that children of binge-drinking mothers exhibited especially severe cognitive and behavioral deficits. Binge drinking may be particularly harmful because it results in high BACs, may occur during critical periods of brain development, and may be associated with repeated withdrawal episodes.
Wind site elevation and tower height effect on short circuit current of DFIG

The use of doubly fed induction generator (DFIG) in large wind turbines has become quite common over the last few years. But the main disadvantage of DFIG is that it's very sensitive to grid disturbance, such as short circuit and voltage dip. It could cause over current in rotor and stator windings. This paper investigates the effect of wind turbine altitude and height of tower on short circuit current.
[Effects of bone marrow mesenchymal stem cells enriched by small intestinal submucosal films on cardiac function and compensatory circulation after myocardial infarction in goats].

OBJECTIVE To investigate effects of the autologous bone mesenchymal stem cells (MSCs) enriched by the small intestinal submucosa (SIS) film implantation on the myocardial structure, cardiac function, and compensatory circulation after myocardial infarction in the goats. METHODS Sixteen black goats were selected and divided randomly into the control group (n= 8)and the experimental group (n= 8). The chronic myocardial infarction models were made by the ligation of the far end of the left anterior descending coronary artery. At the same time, MSCs were aspired from the thigh bone of the goats in the experimental group. MSCs were isolated by the centrifugation through a percoll step gradient and purified by the plating culture and depletion of the non-adherent cells. Primary MSCs were cultured in the DMEM medium supplemented with the fetal bovine serum in vitro. After that, the cultures were labeled by 5- BrdU. The active cells were transplanted into the SIS film. Six weeks after the ligation, the MSCs-SIS film was implanted by its being sutured onto the infarction area; whereas, the control group underwent a sham-operation. In both groups, echocardiographic measurements were performed before infarction, 6 weeks after infarction and 6 weeks after the MSC-collagen implantation, respectively, to assess the myocardial structure and cardiac function. The left coronary artery angiography was performed with the digital subtraction angiography. RESULTS In an assessment of the left ventricular function, at 6 weeks after operation, the stroke volume and the ejection fraction of the control group and the experimental group were 42.81+/-4.91, 37. 06+/-4.75 ml and 59.20%+/-5.41%, 44.56% +/-4.23%, respectively (P<0.05). The end-diastolic volume and the end-systolic volume of the control group and the experimental group were 72.55+/-8.13, 83.31+/-8.61 ml and 29.75+/-5. 98, 46.25+/-6.68 ml, respectively (P<0. 05). The maximal velocity of peak E of control group and experimental group were 54. 85+/-6.35 cm/s and 43.14+/-4.81cm/s (P<0. 01); and the maximal velocity of peak A of control group and experimental group were 52.33+/-6.65 cm/s and 56.91+/-6.34 cm/s (P>0. 05). Echocardiography showing a distinctly dilatation of left ventricle with the ventricular dyskinesia in control group, but without the ventricular dyskinesia in experimental group. The selective-coronary angiography revealed that the obvious compensatory circulation established between the anterior descending branch and the left circumflex branch in the experimental group. CONCLUSION Implantation of the autologous MSCs enriched by the SIS film can prevent dilatation of the left ventricular chamber and can improve the contractile ability of the myocardium, cardiac function, and collateral perfusion.
Platelet glycoprotein IIb/IIIa inhibitors: basic and clinical aspects.

Glycoprotein IIb/IIIa (GPIIb-IIIa) complexes (integrin αIIbβ3) mediate platelet aggregation by binding fibrinogen or von Willebrand factor (vWF), protein cofactors that form bridges between adjacent platelets. The cross-linked adhesive proteins assemble platelets into the aggregate. Agents that block the function of the GPIIb-IIIa complex of platelets constitute a powerful new generation of antithrombotic drugs.1 Among the short- and long-term aims of such drugs are (1) to provide immediate relief in the case of ongoing arterial thrombosis and (2) to eliminate excessive platelet reactivity in diseased vessels so that occlusive thrombi and restenosis do not occur, while allowing sufficient hemostasis to prevent spontaneous bleeding. It should be emphasized that stenosis and partial occlusion are both prothrombotic, with increased shear stress promoting platelet activation. Under these conditions, vWF plays a major role in the mediation of thrombus formation, interacting with GPIIb-IIIa and the adhesion receptor GPIb.2 Otherwise, fibrinogen is the major cofactor of platelet aggregation, essentially binding through a dodecapeptide sequence (aa400 to aa411) present at the carboxy terminus of each γ chain. Binding of vWF and other adhesive proteins, such as fibronectin, to GPIIb-IIIa is mediated by the Arg-Gly-Asp (RGD) sequence, a universal mediator of cellular interactions with the extracellular matrix.1 2 3 Anti–GPIIb-IIIa drugs block this final step of the platelet aggregation process. They also block the “outside-in” signaling that follows the binding of adhesive proteins to activated GPIIb-IIIa and the onset of platelet aggregation.3 This signaling may promote events such as secretion, clot retraction, and the expression of procoagulant activity; therefore, its inhibition extends the influence of anti–GPIIb-IIIa drugs beyond the blocking of platelet-to-platelet cohesion. The present review will mostly be illustrated by results obtained with abciximab (c7E3 Fab, ReoPro), a chimeric antibody fragment that is the most widely used of the new …
A game-theoretic approach to resource allocation in the cloud

Different algorithms have been applied to solve the shared resource allocation problem in the cloud environment, some of which are based on game theory with the aim to maximize the provider's profit while ensuring good customer experience. However, the traditional methods do not account for the users' rationality. In addition to being selfish by nature, users gain experience and knowledge from their repetitive participation in a process. They can then choose the best action that guarantees their benefit. This learning process is not accounted for in static traditional (queuing theory based) methods. In game theory, a player's payoff is not affected only by his chosen action, but also by the set of actions/profile chosen by other players. In our paper, we propose a strategic game model for resource allocation in the cloud environment. We take into consideration the interaction between two clients, the service level agreement between the client and the provider, and the server load due to the allocation of other players. Our results show that a Nash equilibrium is achieved for some specific probability values assigned along with the choice of a certain provider.
Molecular Characterization of Noroviruses and Rotaviruses Involved in a Large Outbreak of Gastroenteritis in Northern Italy

ABSTRACT Noroviruses and rotaviruses from a gastroenteritis outbreak affecting >300 people near Garda Lake (Northern Italy) in 2009 were investigated. Characterization of viruses from 40 patient stool samples and 5 environmental samples identified three distinct rotavirus and five norovirus genotypes; two of the latter were detected in both patient and environmental samples.
Monolithic implementation of phase shifted switched capacitor step-down DC-DC converter for portable power applications

This paper presents analysis and design of a reconfigurable switched capacitor (SC) step-down DC-DC converter architecture suitable for on-chip integrated portable power supplies. Comprising basic SC cells, the proposed DC-DC converter is modular in architecture, and can be viewed as a dual of the multiphase buck converter architecture. The SC converter with integrated capacitors is designed in a standard 180 nm CMOS process to operate in 1/3 and 1/2 conversion ratio modes. The converter is designed to operate with input voltage varying from 2.7V to 5.5V, and switching frequency varying from 10 MHz to 70 MHz, while delivering up to 250mA load current at 1.3V output voltage. SPICE simulation results based on detailed process models are presented. It is shown that efficiency is significantly higher than in a linear regulator operating over the complete specified input voltage range, and also reduces the off-chip input and output filter capacitor requirement.