Miracle-dz/UniFAR-FTUs huggingface dataset:
Blood Pressure Response to Losartan and Continuous Positive Airway Pressure in Hypertension and Obstructive Sleep Apnea.

RATIONALE Obstructive sleep apnea (OSA) is common in people with hypertension, particularly resistant hypertension. Treatment with an antihypertensive agent alone is often insufficient to control hypertension in patients with OSA. OBJECTIVES To determine whether continuous positive airway pressure (CPAP) added to treatment with an antihypertensive agent has an impact on blood pressure (BP) levels. METHODS During the initial 6-week, two-center, open, prospective, case-control, parallel-design study (2:1; OSA/no-OSA), all patients began treatment with an angiotensin II receptor antagonist, losartan, 50 mg daily. In the second 6-week, sex-stratified, open, randomized, parallel-design study of the OSA group, all subjects continued to receive losartan and were randomly assigned to either nightly CPAP as add-on therapy or no CPAP. MEASUREMENTS AND MAIN RESULTS Twenty-four-hour BP monitoring included assessment every 15 minutes during daytime hours and every 20 minutes during the night. Ninety-one patients with untreated hypertension underwent a home sleep study (55 were found to have OSA; 36 were not). Losartan significantly reduced systolic, diastolic, and mean arterial BP in both groups (without OSA: 12.6, 7.2, and 9.0 mm Hg; with OSA: 9.8, 5.7, and 6.1 mm Hg). Add-on CPAP treatment had no significant changes in 24-hour BP values but did reduce nighttime systolic BP by 4.7 mm Hg. All 24-hour BP values were reduced significantly in the 13 patients with OSA who used CPAP at least 4 hours per night. CONCLUSIONS Losartan reduced BP in OSA, but the reductions were less than in no-OSA. Add-on CPAP therapy resulted in no significant changes in 24-hour BP measures except in patients using CPAP efficiently. Clinical trial registered with www.clinicaltrials. gov (NCT00701428). ​
Strain Differences in Continued Avoidance after a Short or Long Retention Interval

3 experiments examined the effects of CS-only trials and retention interval upon resistance to extinction of an avoidance response. In Exps. I and II, nonemotional Holtzman rats showed high resistance to extinction regardless of experimental conditions. In Exp. III, emotional Sasco rats showed high resistance to extinction for a short delay while forgetting was almost complete for the longer retention interval. The results were discussed in terms of implications for elicitation theory.
Social Capital in Management Information Systems Literature

Social capital represents resources or assets rooted in an individual's or group's network of social relations. It is a multidimensional and multilevel concept characterized by diverse definitions and conceptualizations, all of which focus on the structure and/or on the content of the social relations. A common conceptualization of social capital in information systems research consists of a structural, relational and cognitive dimension. The structural dimension represents the configuration of the social network and the characteristics of its ties. The relational dimension epitomizes assets embedded in the social relations, such as trust, obligations, and norms of reciprocity. The cognitive dimension is created by common codes, languages and narratives, and represents a shared context that facilitates interaction. To singular or collective network members, social capital can be a source of solidarity, information, cooperation, collaboration and influence. Ultimately, social capital has been and will remain sound theoretical grounding upon which to study information systems affected by social relationships and their embedded assets.
Differential Target Gene Activation by the Staphylococcus aureus Two-Component System saeRS

ABSTRACT The saePQRS system of Staphylococcus aureus controls the expression of major virulence factors and encodes a histidine kinase (SaeS), a response regulator (SaeR), a membrane protein (SaeQ), and a lipoprotein (SaeP). The widely used strain Newman is characterized by a single amino acid change in the sensory domain of SaeS (Pro18 in strain Newman [SaeSP], compared with Leu18 in other strains [SaeSL]). SaeSP determines activation of the class I sae target genes (coa, fnbA, eap, sib, efb, fib, sae), which are highly expressed in strain Newman. In contrast, class II target genes (hla, hlb, cap) are not sensitive to the SaeS polymorphism. The SaeSL allele (saeSL ) is dominant over the SaeSP allele, as shown by single-copy integration of saePQRSL in strain Newman, which results in severe repression of class I target genes. The differential effect on target gene expression is explained by different requirements for SaeR phosphorylation. From an analysis of saeS deletion strains and strains with mutated SaeR phosphorylation sites, we concluded that a high level of SaeR phosphorylation is required for activation of class I target genes. However, a low level of SaeR phosphorylation, which can occur independent of SaeS, is sufficient to activate class II target genes. Using inducible saeRS constructs, we showed that the expression of both types of target genes is independent of the saeRS dosage and that the typical growth phase-dependent gene expression pattern is not driven by SaeRS.
Comparative Evaluation of Gingival Depigmentation using Tetrafluoroethane Cryosurgery and Gingival Abrasion Technique: Two Years Follow Up.

OBJECTIVE A comparative evaluation of the gingival depigmentation by using Tetrafluoroethane cryosurgery and the gingival abrasion technique - 2 years of follow up. MATERIAL AND METHODS Ten systemically healthy patients who were aged 18 to 36 years were selected for the study. Tetrafluoroethane was used for the cryosurgical depigmentation and the gingival abrasion technique used a coarse flame shaped bur. The presence or absence of pigmentation was tabulated, based on the GPI (Gingival Pigmentation Index). For the statistical analysis, Freidman's test was used. RESULTS The keratinization was completed within a week after the application of the cryogen and about 10 days after the gingival abrasion technique was done. The statistical analysis which was done after 90th, 180th days and 2 years. The p-value which was obtained (p<.001) showed the superiority of cryosurgery over the gingival abrasion. During the follow up period, no side effects were seen for both the techniques and the improved aesthetics was maintained upto 2 years. CONCLUSION The use of cryogen Tetrafluoroethane is easy, practical and inexpensive as compared to gingival abrasion, due to its high rate of recurrence. Hence, it is more acceptable to the patients and the operator. Further studies are needed to assess the long term effectiveness of the cryosurgical method of depigmentation.
El enfoque EMES de la empresa social desde una perspectiva comparada

Nuestro analisis se estructura de la siguiente manera: en la primera parte describimos las distintas escuelas de pensamiento de las que parten los conceptos, asi como sus respectivos contextos en Europa y en los EE.UU. En la segunda parte analizamos cuidadosamente el enfoque de EMES, que radica en la historica tradicion europea del tercer sector. Este analisis allana el camino para la tercera parte, que examina las convergencias y divergencias conceptuales entre las distintas escuelas y de sus consecuencias para el debate. Mas alla de las discusiones conceptuales, a continuacion destacamos el lugar y el papel del emprendimiento social en el conjunto de la economia y su interaccion con el mercado, la sociedad civil y las politicas publicas. En la ultima parte, observamos de que modo las diferentes escuelas han condicionado el debate en distintas partes del mundo.
Wideband inductorless CMOS RF front-end for LTE receivers

This paper presents a new design of inductorless wideband front-end receiver using 130 nm CMOS technology for LTE bands of 0.7 GHz to 3 GHz. The RF front-end receiver consists of the microstrip antenna, self-bias resistive feedback low-noise amplifier, active balun and folded mixer architecture. The miniature antenna provides good matching results for the entire band of interest. Optimization of low-noise amplifier using linearization technique followed by NMOS switches mixer stage are effectively used to achieve maximum gain, low noise figure, and low power consumption. The designed receiver exhibits a maximum gain of 22 dB, maximum noise figure of 7.5 dB, minimum 3rd order intercept point (IIP3) of −9.2 dBm, and DC power consumption of 22 mW at 1.2 V power supply. Using these optimizations, our proposed receiver can be a good candidate for LTE applications.
Recall of severe hypoglycaemia and self‐estimated state of awareness in type 1 diabetes

The ability of people with insulin‐treated diabetes to remember severe hypoglycaemia and the consistency of their self‐estimated awareness of hypoglycaemia are not well documented but are important in clinical practice. The aim of this study is to assess recall of severe hypoglycaemia in patients with type 1 diabetes and to evaluate the feasibility of a simple method for clinical classification of the awareness of hypoglycaemia.
Review of semiochemicals that mediate the oviposition of mosquitoes: a possible sustainable tool for the control and monitoring of Culicidae

Review of semiochemicals that mediate the oviposition of mosquitoes: a possible sustainable tool for the control and monitoring of Culicidae. The choice for suitable places for female mosquitoes to lay eggs is a key-factor for the survival of immature stages (eggs and larvae). This knowledge stands out in importance concerning the control of disease vectors. The selection of a place for oviposition requires a set of chemical, visual, olfactory and tactile cues that interact with the female before laying eggs, helping the localization of adequate sites for oviposition. The present paper presents a bibliographic revision on the main aspects of semiochemicals in regard to mosquitoes' oviposition, aiding the comprehension of their mechanisms and estimation of their potential as a tool for the monitoring and control of the Culicidae.
Expression of a synthetic gene coding for the amino acid sequence of Clostridium pasteurianum rubredoxin.

A synthetic gene based on the published amino acid sequence for Clostridium pasteurianum rubredoxin was constructed, cloned in Escherichia coli 71/18 and expressed using the T7 RNA polymerase/promoter system in E. coli HMS273. UV/visible spectroscopy and metal analyses indicated that the as-isolated synthetic gene product is a mixture of holo-(i.e. iron-containing) rubredoxin and zinc-substituted rubredoxin, with the latter amounting to approximately 70% of the total rubredoxin. The UV/visible absorption and resonance Raman spectra of the cloned holorubredoxin are characteristic of the native rubredoxin-type iron site. N-terminal amino acid sequencing suggests that the gene product consists of at least three polypeptide species with the initial sequences (approximate relative abundances): Met-Met-Lys-. (63%), blocked (30%) and Met-Lys-. (7%). The blocked portion presumably consists of a mixture of nMet-Met-Lys-. and nMet-Lys-. , where nMet represents an amino-blocked methionine residue.
Neuroendocrine Activation during Combined Mental and Physical Stress in Women Depends on Trait Anxiety and the Phase of the Menstrual Cycle

The aim of this study was to investigate the influence of trait anxiety and menstrual cycle phase on neuroendocrine activation during combined mental and physical stress procedure in 40 healthy female subjects. Women at the upper (anxious) and lower (nonanxious) limits of the normal range of a trait anxiety scale were exposed to the stress procedure consisting of a mental component (Stroop test) and handgrip exercise. Salivary cortisol levels, cardiovascular parameters, and cognitive performance in the Stroop test were evaluated. Stress‐induced cortisol levels and the rise in systolic blood pressure were affected by both trait anxiety and menstrual cycle phase. The stress model used induced a significant cortisol elevation only in anxious women in the follicular phase. This group of women also exhibited greater increases in systolic blood pressure in response to handgrip exercise as compared to anxious ones in the luteal phase and to nonanxious women in either phase. In nonanxious women, stress‐induced cortisol levels positively correlated with cognitive performance. In contrast, a negative correlation trend was observed in anxious subjects. Thus, in subjects with low but not high trait anxiety, enhanced cortisol concentrations seem to be associated with better cognitive performance. The results suggest that women with high trait anxiety exhibit greater cardiovascular and hormonal sensitivity to stress stimuli during the follicular phase.
Xrcc3 Induces Cisplatin Resistance by Stimulation of Rad51-Related Recombinational Repair, S-Phase Checkpoint Activation, and Reduced Apoptosis

Eukaryotic cells respond to DNA damage by activation of DNA repair, cell cycle arrest, and apoptosis. Several reports suggest that such responses may be coordinated by communication between damage repair proteins and proteins signaling other cellular responses. The Rad51-guided homologous recombination repair system plays an important role in the recognition and repair of DNA interstrand crosslinks (ICLs), and cells deficient in this repair pathway become hypersensitive to ICL-inducing agents such as cisplatin and melphalan. We investigated the possible role of the Rad51-paralog protein Xrcc3 in drug resistance. Xrcc3 overexpression in MCF-7 cells resulted in 1) a 2- to 6-fold resistance to cisplatin/melphalan, 2) a 2-fold increase in drug-induced Rad51 foci, 3) an increased cisplatin-induced S-phase arrest, 4) decreased cisplatin-induced apoptosis, and 5) increased cisplatin-induced DNA synthesis arrest. Interestingly, Xrcc3 overexpression did not alter the doubling time or cell cycle progression in the absence of DNA damage. Furthermore, Xrcc3 overexpression is associated with increased Rad51C protein levels consistent with the known interaction of these two proteins. Our results demonstrate that Xrcc3 is an important factor in DNA cross-linking drug resistance in human tumor cells and suggest that the response of the homologous recombinational repair machinery and cell cycle checkpoints to DNA cross-linking agents is intertwined.
Orchestration of Stepwise Synaptic Growth by K+ and Ca2+ Channels in Drosophila

Synapse formation is tightly associated with neuronal excitability. We found striking synaptic overgrowth caused by Drosophila K+-channel mutations of the seizure and slowpoke genes, encoding Erg and Ca2+-activated large-conductance (BK) channels, respectively. These mutants display two distinct patterns of “satellite” budding from larval motor terminus synaptic boutons. Double-mutant analysis indicates that BK and Erg K+ channels interact with separate sets of synaptic proteins to affect distinct growth steps. Post-synaptic L-type Ca2+ channels, Dmca1D, and PSD-95-like scaffold protein, Discs large, are required for satellite budding induced by slowpoke and seizure mutations. Pre-synaptic cacophony Ca2+ channels and the NCAM-like adhesion molecule, Fasciclin II, take part in a maturation step that is partially arrested by seizure mutations. Importantly, slowpoke and seizure satellites were both suppressed by rutabaga mutations that disrupt Ca2+/CaM-dependent adenylyl cyclase, demonstrating a convergence of K+ channels of different functional categories in regulation of excitability-dependent Ca2+ influx for triggering cAMP-mediated growth plasticity.
The role of diamondback moth cuticle surface compounds in pre‐penetration growth of the entomopathogen Isaria fumosoroseus

Transcript patterns elicited in response to hosts can reveal how fungi recognize suitable hosts and the mechanisms involved in pathogenicity. These patterns could be fashioned by recognition of host‐specific topographical features or by chemical components displayed or released by the host. We investigated this in three isolates of Isaria fumosoroseus which has shown considerable pathogenic ability against Plutella xylostella. Conidia inoculated to hind wings had the highest germination ability while the conidia inoculated to head regions showed the lowest germination. Conidia applied to diamondback moth wings showed slightly lower rates of germination than those incubated on SDA. Although I. funosoroseus isolates germinated well on crude methanol extracts, only low levels of germination occurred on hexane and dichloromethane extracts. Similarly, poor germination was also observed on diamondback moth hind wing from which cuticular lipids were extracted by using methanol when compared to the untreated hind wings showing that simple polar compounds are required to stimulate germination before the fungus can make effective use of a complex mixture of non‐polar lipids. Such studies could address the origin of intraspecies differences and correlate these differences with the underlying metabolic and biosynthetic differences that define different host ranges. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Radiation from high-speed particles.

The theory of the weak visible radiation produced in a solvent by the action of gamma rays is discussed. It is shown why this phenomenon cannot be interpreted as luminescence. The radiation exhibited a property of extremely pronounced spatial asymmetry which lead to the theory that the radiation is produced by electrons which move uniformly in the substance with a velocity which exceeds the phase velocity of light in this medium. Angular distributions of the radiation intensity were determined for four liquids. The value of the angle was found to increase with increase in the index of refraction of the solvent. The measurement oi the intensity of the radiation by the proper electronic circuit is discussed. Applications of the radiation in particle detectors, in the study of broad cosmic showers, and in the measurement of energy are discussed. (C.J.G.)
Vitamin D3 Up-Regulated Protein 1 Mediates Oxidative Stress Via Suppressing the Thioredoxin Function1

As a result of identifying the regulatory proteins of thioredoxin (TRX), a murine homologue for human vitamin D3 up-regulated protein 1 (VDUP1) was identified from a yeast two-hybrid screen. Cotransfection into 293 cells and precipitation assays confirmed that mouse VDUP1 (mVDUP1) bound to TRX, but it failed to bind to a Cys32 and Cys35 mutant TRX, suggesting the redox-active site is critical for binding. mVDUP1 was ubiquitously expressed in various tissues and located in the cytoplasm. Biochemical analysis showed that mVDUP1 inhibited the insulin-reducing activity of TRX. When cells were treated with various stress stimuli such as H2O2 and heat shock, mVDUP1 was significantly induced. TRX is known to interact with other proteins such as proliferation-associated gene and apoptosis signal-regulating kinase 1. Coexpression of mVDUP1 interfered with the interaction between TRX and proliferation-associated gene or TRX and ASK-1, suggesting its roles in cell proliferation and oxidative stress. To investigate the roles of mVDUP1 in oxidative stress, mVDUP1 was overexpressed in NIH 3T3 cells. When cells were exposed to stress, cell proliferation was declined with elevated apoptotic cell death compared with control cells. In addition, c-Jun N-terminal kinase activation and IL-6 expression were elevated. Taken together, these results demonstrate that mVDUP1 functions as an oxidative stress mediator by inhibiting TRX activity.
Atrial Fibrillation After Cardiac Surgery: Pathophysiology and Treatment

Atrial fibrillation (AF) occurs in 25% to 60% of patients after cardiac surgery. It is most consistently associated with advanced age and valvular heart operations. Despite improving knowledge of the pathophysiology of chronic AF, postoperative AF remains an obstinate clinical problem. It is associated with an increased risk of stroke, longer hospital stay, and higher hospital expenditure. Consequently, there has been great interest in strategies to prevent and treat this arrhythmia. Treatment for postoperative AF may require immediate electrical cardioversion for hemodynamically unstable patients. Heart rate control is useful in most patients, with anticoagulation considered after 48 hours. Antiarrhythmic therapy is often effective in restoring sinus rhythm but its use needs to be balanced against the patient's risk of proarrhythmic side effects such as torsade de pointes.
THE EFFECT OF SOIL CONTAMINATION WITH DIESEL OIL AND PETROL ON THE NITRIFICATION PROCESS

The effect of soil contamination with diesel oil and petrol on the nitrification process was investigated in a laboratory experiment. Samples of typical brown soil developed from loamy sand, of pH of 6.6 in 1M KCl, Hh –11.38 mmol + kg –1 soil, S – 77.67 mmol + kg –1 soil and Corg – 8.50 g kg –1 were analyzed. The experiment was performed in three replications, and for each test 100 g air-dry soil sample was placed in 150 cm3 beakers. Soil samples were contaminated with diesel oil and petrol with the addition of rapeseed oil and ethanol. The source of nitrogen was ammonium sulfate in the amount of 0 and 250 mg N per kg –1 soil. The content of N-NO3 – and N-NH4 + was determined on experimental days 14, 28 and 42. Soil moisture was kept constant at 50% capillary water capacity throughout the experiment. Fertilizer nitrogen was subject to strong immobilization in soil contaminated with diesel oil and petrol. Both pollutants strongly inhibited the nitrification process. Diesel oil had a much stronger inhibitory effect on nitrification than petrol. Rapeseed oil also proved to be a powerful inhibiting factor. On experimental day 42, diesel oil reduced ammonium cation oxidation by 99%, and petrol – by 88%.