Miracle-dz/UniFAR-FTUs huggingface dataset:
Repulsion-Propulsion Firefly Algorithm with Fast Convergence to Solve Highly Multi-Modal Problems

This paper proposes a modified firefly algorithm (PropFA) to solve highly multimodal problems with fast convergence. In this algorithm every firefly is fitted with a short term memory which facilitates the "Repulsion" force acting on every firefly whereas the introduction of brightness of the best firefly in the movement equation facilitates "Propulsion" force acting on the firefly. Furthermore; no firefly is allowed to move beyond its maximum stride parameter to prevent premature convergence. All other parameters α,β and γ and are designed to be adaptive to suite to almost all multimodal problems without setting them to any a-priori values. Efficiency of PropFA is then verified over six standard test functions. In all of them it is observed that PropFA converges faster than FA and PSO.
A Secure Agent Based Architecture for Resource Allocation in Cloud Computing

Resource allocation is most challenging task in cloud computing where the service providers seeks to find an effective and efficient resource allocation that meets all demands of users as well as sustain the quality of service. In this paper we have proposed an agent based architecture for resource allocation in dynamic environment by defining the roles at each level. Proposed architecture has the various strategies related to resource allocation such reliability, performance, scalability as well as security related issues in distributed environment. This paper also describe the various proposed architecture by researcher and their limitations. Proposed architecture overcome the all limitation previously proposed by researchers.
Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacological treatment in patients with heart failure and chronic atrial fibrillation: a randomized, controlled study.

BACKGROUND Uncontrolled studies have suggested that atrioventricular junction ablation and pacemaker implantation have beneficial effects on quality of life in patients with chronic atrial fibrillation (AF). METHODS AND RESULTS We performed a multicenter, controlled, randomized, 12-month evaluation of the clinical effects of atrioventricular junction ablation and VVIR pacemaker (Abl+Pm) versus pharmacological (drug) treatment in 66 patients with chronic (lasting >6 months) AF who had clinically manifest heart failure and heart rate >90 bpm on 3 standard ECGs recorded at rest during stable clinical conditions on different days. Before completion of the study, withdrawals occurred in 8 patients of the drug group and in 4 patients of the Abl+Pm group. At the end of the 12 months, the 28 Abl+Pm patients who completed the study showed lower scores in palpitations (-78%; P=0.000) and effort dyspnea (-22%; P=0.05) than the 26 of the drug group. Lower scores, although not significant, were also observed for exercise intolerance (-20%), easy fatigue (-17%), chest discomfort (-50%), Living with Heart Failure Questionnaire (-14%), New York Heart Association functional classification (-4%), and Activity scale (-12%). The intrapatient comparison between enrollment and month 12 showed that in the Abl+Pm group, all variables except easy fatigue improved significantly from 14% to 82%. However, because an improvement was also observed in the drug group, the difference between the 2 groups was significant only for palpitations (P=0.000), effort dyspnea (P=0.01), exercise intolerance (P=0.005), easy fatigue (P=0.02), and chest discomfort (P=0.02). Cardiac performance, evaluated by means of standard echocardiogram and exercise test, did not differ significantly between the 2 groups and remained stable over time. CONCLUSIONS In patients with heart failure and chronic AF, Abl+Pm treatment is effective and superior to drug therapy in controlling symptoms, although its efficacy appears to be less than that observed in uncontrolled studies because some improvement can also be expected in medically treated patients. Cardiac performance is not modified by the treatment.
VarCards: an integrated genetic and clinical database for coding variants in the human genome

Abstract A growing number of genomic tools and databases were developed to facilitate the interpretation of genomic variants, particularly in coding regions. However, these tools are separately available in different online websites or databases, making it challenging for general clinicians, geneticists and biologists to obtain the first-hand information regarding some particular variants and genes of interest. Starting with coding regions and splice sties, we artificially generated all possible single nucleotide variants (n = 110 154 363) and cataloged all reported insertion and deletions (n = 1 223 370). We then annotated these variants with respect to functional consequences from more than 60 genomic data sources to develop a database, named VarCards (http://varcards.biols.ac.cn/), by which users can conveniently search, browse and annotate the variant- and gene-level implications of given variants, including the following information: (i) functional effects; (ii) functional consequences through different in silico algorithms; (iii) allele frequencies in different populations; (iv) disease- and phenotype-related knowledge; (v) general meaningful gene-level information; and (vi) drug–gene interactions. As a case study, we successfully employed VarCards in interpretation of de novo mutations in autism spectrum disorders. In conclusion, VarCards provides an intuitive interface of necessary information for researchers to prioritize candidate variations and genes.
Response: Commentary: A construct divided: prosocial behavior as helping, sharing, and comforting subtypes

*Correspondence: Kristen A. Dunfield, Department of Psychology, Center for Research in Human Development, Concordia University, Montreal, QC H4B 1R6, Canada e-mail: kristen.dunfield@concordia.ca The development and maintenance of prosocial, other-oriented behaviors has been of considerable recent interest. Though it is clear that prosocial behaviors emerge early and play a uniquely important role in the social lives of humans, there is less consensus regarding the mechanisms that underlie and maintain these fundamental acts. The goal of this paper is to clarify inconsistencies in our understanding of the early emergence and development of prosocial behavior by proposing a taxonomy of prosocial behavior anchored in the social-cognitive constraints that underlie the ability to act on behalf of others. I will argue that within the general domain of prosocial behavior, other-oriented actions can be categorized into three distinct types (helping, sharing, and comforting) that reflect responses to three distinct negative states (instrumental need, unmet material desire, and emotional distress). In support of this proposal, I will demonstrate that the three varieties of prosocial behavior show unique ages of onset, uncorrelated patterns of production, and distinct patterns of individual differences. Importantly, by differentiating specific varieties of prosocial behavior within the general category, we can begin to explain inconsistencies in the past literature and provide a framework for directing future research into the ontogenetic origins of these essential social behaviors.
MusicFX: an arbiter of group preferences for computer supported collaborative workouts

Environmental factors affecting shared spaces are typically designed to appeal to the broadest audiences they are expected to serve, ignoring the preferences of the people actually inhabiting the environment at any given time. Examples of such factors include the lighting, temperature, decor or music in the common areas of an office building. We have designed and deployed MUSICFX, a group preference arbitration system that allows the members of a fitness center to influence, but not directly control, the selection of music in a fitness center. We present a number of empirical results from our work with this intelligent environment: the results of a poll of fitness center members, a quantitative evaluation of the performance of a group preference arbitrator in a shared environment, and some interesting anecdotes about members’ experiences with the system.
Structure-Templated Predictions of Novel Protein Interactions from Sequence Information

The multitude of functions performed in the cell are largely controlled by a set of carefully orchestrated protein interactions often facilitated by specific binding of conserved domains in the interacting proteins. Interacting domains commonly exhibit distinct binding specificity to short and conserved recognition peptides called binding profiles. Although many conserved domains are known in nature, only a few have well-characterized binding profiles. Here, we describe a novel predictive method known as domain–motif interactions from structural topology (D-MIST) for elucidating the binding profiles of interacting domains. A set of domains and their corresponding binding profiles were derived from extant protein structures and protein interaction data and then used to predict novel protein interactions in yeast. A number of the predicted interactions were verified experimentally, including new interactions of the mitotic exit network, RNA polymerases, nucleotide metabolism enzymes, and the chaperone complex. These results demonstrate that new protein interactions can be predicted exclusively from sequence information.
Approche temporelle de la mémoire de reconnaissance visuelle et atteinte au stade prodromal de la maladie d'Alzheimer

La memoire de reconnaissance visuelle (MRV) est atteinte precocement dans la maladie d'Alzheimer (MA). Or, elle reposerait sur deux processus: la familiarite (simple sentiment d'avoir deja rencontre un item) et la recollection (recuperation de details associes a l'item lors de son encodage). Si la recollection est clairement atteinte au debut de la MA, les resultats concernant la familiarite sont a ce jour contradictoires. Supposee plus rapide que la recollection, la familiarite devrait pouvoir etre evaluee directement par une approche temporelle. Son atteinte dans la MA pourrait alors etre mieux comprise. Pour tester ces hyptheses, la procedure comportementale SAB (Speed and Accuracy Boosting) a ete creee. Permettant d'etudier les proprietes de la MRV (sa vitesse-limite, (Articles 1 et 2, ou sa nature "bottom-up", Article 3) ainsi que l'hypothese que la familiarite serait plus rapide que la recollection, cette methode s'est montree evaluer majoritairement la familiarite (Article 1). Chez des patients a risque de MA, une dissociation inattendue au sein de la familiarite a alors pu etre revelee, avec une atteinte des signaux tardifs de familiarite (utilises lors d'un jugement classique), mais une preservation des premiers signaux (supportant la detection rapide evaluee en SAB) (Article 4). En outre, la segmentation manuelle d'images IRM du lobe temporal interne (premieres regions cerebrales touchees dans la MA, et cles pour la MRV) a ete appliquee a la problematique connexe de l'effet de l'âge au debut de la MA (Article 5). Independamment, ces methodes ont permis de mieux comprendre la MRV et son atteinte au debut de la MA ; leur combinaison s'annonce tres prometteuse.
HUMAN DISEASE

Becauseof the wide individual differencesin susceptibility to noise, industrial deafness must be attacked through hearing conservation rather than through noise measurement-thelatter being used to decide where a hearing conservationprogrammeis necessaryor desirable.The emphasis is on this most important aspect of the need for and implementationof a hearing conservationprogramme; this is treated in detail.
Rapid ADAMTS13 availability impacts treatment for microangiopathic hemolytic anemia and thrombocytopenia

Thrombotic thrombocytopenic purpura (TTP) can present with a spectrum of clinical manifestations. When TTP is in a patient's clinical differential diagnosis, therapeutic plasma exchange (TPE) should be initiated emergently. Enzyme activity level of A Disintegrin And Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13) in conjunction with the evolving clinical picture can guide further therapy, including duration and frequency of TPE and choice of fluid replacement. Our experience switching reference laboratories to obtain a more rapid turnaround time of ADAMTS13 activity level resulted in significant changes in clinical management, including fewer overall TPE procedures and the occasional use of albumin for a portion of the replacement fluid in patients without severe deficiency of ADAMTS13 and a low index of clinical suspicion for TTP. J. Clin. Apheresis 31:419–422, 2016. © 2015 Wiley Periodicals, Inc.
Energetics of protein–DNA interactions

Protein–DNA interactions are vital for many processes in living cells, especially transcriptional regulation and DNA modification. To further our understanding of these important processes on the microscopic level, it is necessary that theoretical models describe the macromolecular interaction energetics accurately. While several methods have been proposed, there has not been a careful comparison of how well the different methods are able to predict biologically important quantities such as the correct DNA binding sequence, total binding free energy and free energy changes caused by DNA mutation. In addition to carrying out the comparison, we present two important theoretical models developed initially in protein folding that have not yet been tried on protein–DNA interactions. In the process, we find that the results of these knowledge-based potentials show a strong dependence on the interaction distance and the derivation method. Finally, we present a knowledge-based potential that gives comparable or superior results to the best of the other methods, including the molecular mechanics force field AMBER99.
Protection of information in computer systems

The topics of protection of information, data security, and privacy In the domain of Computer systems are of particular significance in our society, which is increasingly keeping its records in computer based systems. This paper is an excellant technical survey of the mechanics of protecting computer-stored information from unauthorised use or modifications, with a focus on tire conceptual framework necessary tu enforce data security.
High-performance ambipolar self-assembled Au/Ag nanowire based vertical quantum dot field effect transistor

Most lateral PbSe quantum dot field effect transistors (QD FETs) show a low on current/off current (Ion/Ioff) ratio in charge transport measurements. A new strategy to provide generally better performance is to design PbSe QD FETs with vertical architecture, in which the structure parameters can be tuned flexibly. Here, we fabricated a novel room-temperature operated vertical quantum dot field effect transistor with a channel of 580 nm, where self-assembled Au/Ag nanowires served as source transparent electrodes and PbSe quantum dots as active channels. Through investigating the electrical characterization, the ambipolar device exhibited excellent characteristics with a high Ion/Ioff current ratio of about 1 × 105 and a low sub-threshold slope (0.26 V/decade) in the p-type regime. The all-solution processing vertical architecture provides a convenient way for low cost, large-area integration of the device.
A 56GHz LC-tank VCO with 17% tuning range in 65nm bulk CMOS for wireless HDMI applications

A voltage controlled oscillator (VCO) with 56GHz central frequency and 17% tuning range is presented. The oscillation frequency is tuned both by an analog input and a three-bit digital control bus using the same type of differential varactors. It achieves a record FOMT (considering tuning range) of 186.8 dBc/Hz and it is able to address the full wireless HDMI band. The VCO is implemented in a 65nm bulk CMOS process and dissipates 15 mW from a 1.2 V supply.
Fungal Pathogen Reduces Potential for Malaria Transmission

Using a rodent malaria model, we found that exposure to surfaces treated with fungal entomopathogens following an infectious blood meal reduced the number of mosquitoes able to transmit malaria by a factor of about 80. Fungal infection, achieved through contact with both solid surfaces and netting for durations well within the typical post-feed resting periods, was sufficient to cause >90% mortality. Daily mortality rates escalated dramatically around the time of sporozoite maturation, and infected mosquitoes showed reduced propensity to blood feed. Residual sprays of fungal biopesticides might replace or supplement chemical insecticides for malaria control, particularly in areas of high insecticide resistance.
Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF

Feeding and sleep are fundamental behaviours with significant interconnections and cross-modulations. The circadian system and peptidergic signals are important components of this modulation, but still little is known about the mechanisms and networks by which they interact to regulate feeding and sleep. We show that specific thermogenetic activation of peptidergic Allatostatin A (AstA)-expressing PLP neurons and enteroendocrine cells reduces feeding and promotes sleep in the fruit fly Drosophila. The effects of AstA cell activation are mediated by AstA peptides with receptors homolog to galanin receptors subserving similar and apparently conserved functions in vertebrates. We further identify the PLP neurons as a downstream target of the neuropeptide pigment-dispersing factor (PDF), an output factor of the circadian clock. PLP neurons are contacted by PDF-expressing clock neurons, and express a functional PDF receptor demonstrated by cAMP imaging. Silencing of AstA signalling and continuous input to AstA cells by tethered PDF changes the sleep/activity ratio in opposite directions but does not affect rhythmicity. Taken together, our results suggest that pleiotropic AstA signalling by a distinct neuronal and enteroendocrine AstA cell subset adapts the fly to a digestive energy-saving state which can be modulated by PDF.
The Genetic Signature of Sex-Biased Migration in Patrilocal Chimpanzees and Humans

A large body of theoretical work suggests that analyses of variation at the maternally inherited mitochondrial (mt)DNA and the paternally inherited non-recombining portion of the Y chromosome (NRY) are a potentially powerful way to reveal the differing migratory histories of men and women across human societies. However, the few empirical studies comparing mtDNA and NRY variation and known patterns of sex-biased migration have produced conflicting results. Here we review some methodological reasons for these inconsistencies, and take them into account to provide an unbiased characterization of mtDNA and NRY variation in chimpanzees, one of the few mammalian taxa where males routinely remain in and females typically disperse from their natal groups. We show that patterns of mtDNA and NRY variation are more strongly contrasting in patrilocal chimpanzees compared with patrilocal human societies. The chimpanzee data we present here thus provide a valuable comparative benchmark of the patterns of mtDNA and NRY variation to be expected in a society with extremely female-biased dispersal.
Impact of kinase activating and inactivating patient mutations on binary PKA interactions

The second messenger molecule cAMP links extracellular signals to intracellular responses. The main cellular cAMP effector is the compartmentalized protein kinase A (PKA). Upon receptor initiated cAMP-mobilization, PKA regulatory subunits (R) bind cAMP thereby triggering dissociation and activation of bound PKA catalytic subunits (PKAc). Mutations in PKAc or RIa subunits manipulate PKA dynamics and activities which contribute to specific disease patterns. Mutations activating cAMP/PKA signaling contribute to carcinogenesis or hormone excess, while inactivating mutations cause hormone deficiency or resistance. Here we extended the application spectrum of a Protein-fragment Complementation Assay based on the Renilla Luciferase to determine binary protein:protein interactions (PPIs) of the PKA network. We compared time- and dose-dependent influences of cAMP-elevation on mutually exclusive PPIs of PKAc with the phosphotransferase inhibiting RIIb and RIa subunits and the protein kinase inhibitor peptide (PKI). We analyzed PKA dynamics following integration of patient mutations into PKAc and RIa. We observed that oncogenic modifications of PKAc(L206R) and RIa(Δ184-236) as well as rare disease mutations in RIa(R368X) affect complex formation of PKA and its responsiveness to cAMP elevation. With the cell-based PKA PPI reporter platform we precisely quantified the mechanistic details how inhibitory PKA interactions and defined patient mutations contribute to PKA functions.
Precoding Design for Multi-Antenna Multicast Broadcast Services With Limited Feedback

The provision for spectrally efficient multicast broadcast services (MBS) is one of the key functional requirements for next generation wireless communication systems. The challenge inherent to MBS is to ensure that all MBS users can be served, and one effective solution to this problem is to employ MIMO multicast transmit precoding. In previous works on MIMO multicast transmit precoding design, the authors either assumed (1) perfect transmitter-side channel state information (CSIT) or (2) special channel conditions that facilitate precoder design with imperfect CSIT. In this paper, we focus on transmit precoding design for MBS where the CSIT is obtained via limited feedback. In addition, we analyze the average minimum receive signal-noise-ratio (RxSNR) among the MBS users and study the order of growth with respect to the number of MBS users, the number of feedback bits, and the number of transmit antennas. Finally, we propose a threshold based feedback reduction scheme and study the tradeoff between feedback cost and performance loss.
Spectral regularization and minEnt regularization

In this paper, we propose the spectral regularization based on the conventional (spatial) regularization and the Fourier analysis. The entropy regularization is further developed and its connection to MinEnt principle is investigated. The underlying geometrical, physical and biological interpretation of spectral and entropic regularization are discussed. Finally, the simulation examples are given followed by summary.
Generic conversions of abstract syntax representations

In this paper we present a datatype-generic approach to syntax with variable binding. A universe specifies the binding and scoping structure of object languages, including binders that bind multiple variables as well as sequential and recursive scoping. Two interpretations of the universe are given: one based on parametric higher-order abstract syntax and one on well-typed de Bruijn indices. The former provides convenient interfaces to embedded domain-specific languages, but is awkward to analyse and manipulate directly, while the latter is a convenient representation in implementations, but is unusable as a surface language. We show how to generically convert from the parametric HOAS interpretation to the de Bruijn interpretation thereby taking the pain from DSL developer to write the conversion themselves.