Miracle-dz/UniFAR-FTUs huggingface dataset:
Videojogos: um novo meio de entretenimento de idosos?

Resumo: Assiste-se actualmente a um marcado envelhecimento da populacao, especialmente nos paises mais desenvolvidos. Em Portugal, “dentro de aproximadamente 15 anos, um em cada cinco portugueses tera 65 ou mais anos” (Paul & Fonseca, 2005:15). Esta populacao, na sua grande maioria, tem actividades de ocupacao limitadas, pois ja nao exercem qualquer profissao e veem as suas actividades de entretenimento igualmente reduzidas. Atendendo ao aumento demografico desta populacao, urge encontrar para a mesma alternativas de entretenimento que fornecam oportunidades de prazer e bemestar. Recentemente tem-se verificado que esta populacao para alem de se mostrar muito receptiva as novas tecnologias de informacao, tem, ate, optado por recorrer aos videojogos como actividade de ocupacao (Schiesel, 2007), quando tem contacto com este meio de entretenimento. De facto, alguns estudos tem estudado os efeitos desta actividade nesta populacao e sugerem que tal conduz a beneficios nas seguintes areas: • Tempos de reaccao (Clark, Lanphear, & Riddick, 1987; Goldstein et al., 1997); • Bem-estar subjectivo (Goldstein et al., 1997) e sentimentos de sucesso e de realizacao (Hollander & Plummer, 1986); • Aumento dos niveis de atencao (Hollander & Plummer, 1986); • Aumento da ocupacao construtiva de tempos-livres (Hollander & Plummer, 1986; Weisman, 1983; Beasley, 1989); • Aumento do Quociente Intelectual, avaliado atraves da WAIS-R (Drew & Waters, 1986) • Aumento do contacto social (Riddick et al., 1987; Beasley, 1989). Neste trabalho propomo-nos, entao, a explorar, em maior detalhe, as potencialidades da utilizacao dos Videojogos como meio de entretenimento da populacao idosa.
Multi‐Length‐Scale Morphologies Driven by Mixed Additives in Porphyrin‐Based Organic Photovoltaics

A new category of deep-absorbing small molecules is developed. Optimized devices driven by mixed additives show a remarkable short-circuit current of ≈20 mA cm(-2) and a highest power conversion efficiency of 9.06%. A multi-length-scale morphology is formed, which is fully characterized by resonant soft X-ray scattering, high-angle annular dark film image transmission electron microscopy, etc.
Konditionsbeurteilung per Ultraschall in der Herdenbetreuung

Zusammenfassung In den ersten beiden Teilen dieser Veröffentlichungsreihe wurden die Auswirkungen unterschiedlicher Konditionsverläufe auf Milchleistung und Fruchtbarkeit beschrieben, im dritten Teil Referenzwerte für die Entwicklung der Rückenfettdicke im Laktationsverlauf und für die RFD-Änderung berechnet. Grundlage für diese Berechnungen waren Ultraschallmessungen der Rückenfettdicke bei 46111 Tieren in 78 verschiedenen Betrieben. In dieser Arbeit sollen die Einsatzmöglichkeiten der Methode im Rahmen der tierärztlichen Bestandsbetreuung dargestellt werden. Zu diesem Zweck wurden zwei Betriebe mit einer durchschnittlichen Milchleistung von etwa 9500 Litern FCM pro Kuh und Jahr während eines Jahres regelmäßig besucht und miteinander verglichen. Hierbei zeigte sich, dass hohe Milchleistungen auch ohne extreme Körperfettverluste zu realisieren sind. Wenn sich die durchschnittliche Konditionsentwicklung im Betrieb an der Referenzkurve orientiert, können nicht nur hohe Milchleistungen, sondern gleichzeitig auch gute Fruchtbarkeitsergebnisse erreicht werden.
RNA–protein interactions and control of mRNA stability in neurons

In addition to transcription, posttranscriptional mechanisms play a vital role in the control of gene expression. There are multiple levels of posttranscriptional regulation, including mRNA processing, splicing, editing, transport, stability, and translation. Among these, mRNA stability is estimated to control about 5–10% of all human genes. The rate of mRNA decay is regulated by the interaction of cis‐acting elements in the transcripts and sequence‐specific RNA‐binding proteins. One of the most studied cis‐acting elements is the AU‐rich element (ARE) present in the 3′ untranslated region (3′UTR) of several unstable mRNAs. These sequences are targets of many ARE‐binding proteins; some of which induce degradation whereas others promote stabilization of the mRNA. Recently, these mechanisms were uncovered in neurons, where they have been associated with different physiological phenomena, from early development and nerve regeneration to learning and memory processes. In this Mini‐Review, we briefly discuss the general mechanisms of control of mRNA turnover and present evidence supporting the importance of these mechanisms in the expression of an increasing number of neuronal genes. © 2007 Wiley‐Liss, Inc.
Cognitively Driven Co‐Option and the Evolution of Complex Sexual Displays in Bowerbirds

Two of Darwin’s greatest contributions were his work on sexual selection (Darwin, 1871) and on the evolution of mental processes (Darwin, 1872). Currently, sexual selection is among the most studied topics in evolutionary and behavioral biology (Andersson and Simmons, 2006; Cronin, 1991), but there has been little consideration of how mental ability affects sexual selection (Miller, 2001; Ryan et al., 2009; Boogert et al., 2011). This issue was addressed in the debate between Darwin and Wallace over the adequacy of females to carry out choice needed to produce sexually dimorphic traits in male birds. And while Darwin prevailed in his view that female choice was critical in the evolution of male sexual signals, there remained a widely held view that most species, with the exception of primates, had very limited cognitive ability (Herrick, 1924). Then, starting around 30 years ago, a number of studies showed unexpectedly high levels of mental development in other animals, particularly in birds. Generally, cognitive ability as we use the term here, refers to the ability of individuals to use mental processes to solve problems that under natural conditions leads to increased fitness. Various studies have shown a role for cognition in spatial memory (Kamil and Balda, 1985; Bennett, 1993; Healy and Hurly, 1995; Pravosudov and Clayton, 2002), food theft (Bugnyar and Kotrschal, 2002), vocal ability (Pepperberg, 1999), tool-making (Jones and Kamil,
Ultra-low reflectance, high absorption microcrystalline silicon nano-stalagmite (µc-SiNS)

In this work, microcrystalline silicon nano-stalagmite (µc-SiNS) arrays have been successfully fabricated on glass by catalytic etching process through a template. The template use polystyrene (PS) nanospheres with diameter and density of 30 ∼ 50 nm and 1010/cm2, respectively by a modified nano-phase separation of PS-containing block copolymer. The length of µc-SiNS could be controlled by the duration of etching time. The µc-SiNS exhibit ultra-low reflection approximately 0.3% and absorption around 99% over 300 to 800 nm in wavelength.
Supplemental Data GEF-H 1 Modulates Localized RhoA Activation during Cytokinesis under the Control of Mitotic Kinases

Antibodies The following commercial antibodies were used: For immunoblotting, rabbit anti-14-3-3ζ (C16), rabbit anti-Ect2 (H300), rabbit α-cyclin-B1 (H433), rabbit anti-RhoA (119) (all from Santa Cruz) and rabbit anti-EGFP (A-6455; Molecular Probes) were used at 1:1000 dilution. Monoclonal anti-Aurora A (Abcam) was used at 1:1000 in Western blots and 1:100 in immunofluorescence (IF) experiments. For immunostaining, DM1α monoclonal anti-α-tubulin (Sigma) and anti-actin antibodies (C4; ICN) were used at 1:750 and 1:500 dilution, respectively. Anti-EB1 monoclonal antibody (Transduction Labs) was used at 1:100 in IF experiments. Monoclonal anti-GM130 antibodies were from Transduction Labs and used at 1:250 for IF. Monoclonal anti-GFP antibodies (3E6) for immunoprecipitation experiments were from Molecular Probes. Alexa-labeled secondary antibodies (Molecular Probes) were used at 1:500 for immunostaining.
[Eating disorders in school children].

OBJECTIVE To determine the prevalence of possible eating disorders and inappropriate eating behaviors in school children from six municipalities in the state of Minas Gerais, Brazil. METHODS Cross-sectional study. The Bulimic Investigatory Test of Edinburgh (BITE), Eating Attitude Test (EAT), and Body Image Test were applied to 1,807 public school students with age ranging from 7 to 19 years. RESULTS According to the EAT, 241 students (13.3%), mostly females, had inappropriate eating behaviors. Nineteen students (1.1%) had a BITE score indicating a possible diagnosis of bulimia nervosa. We found that 1,059 students (59%) were unhappy with their body image; 731 students (40%) were on a diet; and 1,014 (56%) exercised to loose weight. In addition, 218 students (12%) presented binge-eating and 175 students (10%) used purgative methods to control weight. CONCLUSIONS We observed a high prevalence of possible eating disorders and inappropriate eating behaviors in the study population, especially among female adolescents. These results are similar to those reported for developed countries. The present findings are relevant for the clinical care of children and adolescents and can serve as the basis for future works aimed at increasing our understanding of the risk factors for these illnesses.
Angéite primaire du système nerveux central : étude d'une cohorte de patients suspects d'un diagnostic d'angéite primaire du SNC et revue de la littérature

Des progres remarquables ont ete accomplis dans la comprehension des maladies inflammatoires qui touchent la paroi des vaisseaux. Lorsque ces maladies affectent le systeme nerveux central (SNC), elles sont d'approche diagnostique et therapeutique difficile. Une histoire compatible avec une vasculite du SNC est celle d'un deficit neurologique qui reste inexplique apres des investigations extensives. Le diagnostique de certitude est base sur une biopsie cerebrale positive. Nous avons effectue une etude retrospective de janvier 1992 jusqu'a decembre 2001 portant sur 8 cas pour lesquels nous avons retenu un diagnostic d'angeite primaire et isolee du SNC (PACNS). Notre collectif a ete caracterise et compare a la litterature. La demarche diagnostique, l'attitude therapeutique et l'evolution clinique ont ete etudiees pour aboutir a une disposition de prise en charge des patients chez lesquels on suspecte une PACNS.
Intelligence économique et performance des entreprises : le cas des PME de haute technologie

L’objectif de cet article est d’etudier le lien entre intelligence economique et performance des entreprises œuvrant dans la haute technologie. En effet, peu d’etudes ont ete consacrees a ce sujet. La methodologie de recherche utilisee est l’etude de cas par comparaison intersites. Les resultats obtenus ont permis d’apprehender la pratique d’intelligence economique dans les PME de haute technologie connaissant du succes. La culture d’innovation de l’equipe dirigeante semble etre le fil conducteur des activites d’intelligence economique, stimulant et orientant la prise de decision. L’intelligence economique apparait alors comme un moyen puissant d’aide a la decision et associee a la performance des entreprises de haute technologie. Elle est motivee par la recherche d’occasions d’affaires et vise principalement l’horizon a long terme. Par ailleurs, les dirigeants gerent de facon strategique leurs reseaux d’information afin d’y puiser les informations necessaires a l’innovation.
Self-enhancement and the life script in future thinking across the lifespan

Studies comparing memory and future event simulation find that future events are more positive, and more often depend on life script events (e.g., culturally normative landmark events) than past events. Previous research does not address the link between this positivity bias and the life stage of college-age participants or their reliance on these scripted events. To examine this positivity bias, narratives of past and anticipated future events were elicited from participants aged 18–74 years, and were examined for reliance on the life script and valence ratings. Results showed that, across age groups, future events were rated as more positive than past events, and that life script events were common in the distant future. Notably, whereas younger adult age groups wrote primarily about their own life script events, older participants more commonly wrote about attending the life script events of significant others, such as children and grandchildren. These findings suggest that simulated future events play a valuable role in self-enhancement across the lifespan. Furthermore, the life script can be viewed as a useful search mechanism when one is missing the episodic details that are more available in memories; however, it is not the source of positivity bias for future events.
On computations with dense structured matrices

We reduce several computations with Hilbert and Vandermonde type matrices to matrix computations of the Hankel-Toeplitz type (and vice versa). This unifies various known algorithms for computations with dense structured matrices and enables us to extend any progress in computations with matrices of one class to the computations with other classes of matrices. In particular, this enables us to compute the inverses and the determinants of n x n matrices of Vandermonde and Hilbert types for the cost of 0(n log2 n) arithmetic operations. (Previously, such results were only known for the more narrow class of Vandermonde and generalized Hilbert matrices.)
Enhanced Extrastriate Activation during Observation of Distorted Finger Postures

Hand and finger postures of other people are important body language cues that strongly contribute to the observer's decision about the person's intentions, thoughts, and attentional state. We compared neuromagnetic cortical activation elicited by color images of natural and distorted finger postures. The distorted postures contained computer-deformed joint angles and thereby easily caught the observer's attention. From about 260 msec onwards, extrastriate occipital areas of both hemispheres were activated more strongly by distorted than natural finger postures. We interpret this result as an early topdown effect of emotional valence on the processing of unusual hand shapes in the extrastriate visual cortex.
Dielectric Relaxation of MIM Capacitor and Its Effect on Sigma-Delta A/D Converters

Dielectric relaxation of capacitors is one of the error sources when determining the accuracy of analog sampled-data systems that are based on charge storage. To perform an accurate characterization of the dielectric relaxation of metal-insulator-metal (MIM) capacitor, techniques based on the voltage recovery principle and the Curie Von Schweidler discharge current approach are developed. To model the dielectric relaxation of the MIM capacitor, Dow's model is selected. An algorithm for the model parameter extraction on the Curie Von Schweidler current has been developed, which shows the phenomenon of dielectric relaxation in detail and is very fast to determine the parameters. Based on the measurement data, a set of model parameters is extracted and verified, which approximates the Curie Von Schweidler law over a sufficiently wide interval of time constants. To study the effect of the dielectric relaxation on the circuit performance of high resolution sigma-delta ADC, a 12-b incremental ADC has been selected as an example for simulation. The simulation results show that the effect of the dielectric relaxation on the performance of the 12-b ADC is not significant. We show that the . major reason for this is that the noise shaping which is enforced by the integrators in SigmaDelta-ADC is almost not affected by the dielectric relaxation phenomenon.
Detection and follow‐up of fibroblast growth factor receptor 3 expression on bone marrow and circulating plasma cells by flow cytometry in patients with t(4;14) multiple myeloma

The t(4;14)(p16;q32) translocation, found in 15% of multiple myeloma (MM) cases, indicates a poor prognosis. Plasma cells (PC) with t(4;14) ectopically express the fibroblast growth factor receptor 3 (FGFR3) tyrosine kinase receptor, which has potential transforming activity and may represent a therapeutic target. To detect FGFR3 protein expression, bone marrow (BM) aspirate from 200 consecutive newly diagnosed (n = 116) or relapsing (n = 74) MM patients was studied by flow cytometry (FC) using anti‐CD138 and anti‐FGFR3 antibodies. FC data was compared to real time quantitative‐polymerase chain reaction (RQ‐PCR) of the IGH‐MMSET and FGFR3 transcripts. An IGH‐MMSET transcript was found in 24/200 patients (12%). In 20 of these, FC detected CD138+/FGFR3+ cells. No expression of FGFR3 was detected in the 4 FGFR3− cases by RQ‐PCR. FGFR3 was never expressed on PC without t(4;14). Circulating PC (CPC) were detected in patients with (11/11) and patients without (13/41) t(4;14). In 2/8 t(4;14) cases studied longitudinally, coexisting FGFR3+ and FGFR3− CPC were observed. Fluorescent in situ hybridisation (FISH) analysis of the FGFR3− subclones showed deletion of the der(14) in one patient. In conclusion, as a supplemental method to RQ‐PCR or FISH, FC analysis of FGFR3 expression is a reliable and routinely available method for the detection and management of new therapeutic approaches of t(4;14) MM.
Le traitement des sols pour la couche de forme, plateforme de chaussée : application à des projets de terrassement dans le département de l'Hérault

Le traitement de sol est une technique complete car elle apporte une efficacite d’execution, une optimisation des performances mecaniques, une valorisation des ressources naturelles, et enfin une economie de cout. Son usage presente un interet certain pour la couche de forme (CDF). Les projets presentes sont des travaux de terrassement pour voirie dans le departement de l’Herault, il s’agit de l’autoroute A75, de son raccordement a l’A9, et de plusieurs voies de desserte. Apres avoir defini les bases nombreuses sur lesquelles s’appuie l’etude, que sont les parametres geotechniques, le traitement, la chaussee et son dimensionnement, quelques exemples de l’efficience du traitement de sol sont exposes avant de passer a l’analyse detaillee des cas. Chaque cas est ensuite presente par son contexte geologique puis l’etude de formulation, le calcul de structure et enfin les couts. Une synthese comparative des resultats clot l’analyse et permet d’extrapoler des recommandations d’usage pour le traitement de la couche de forme. Cette synthese a pour but de demontrer les avantages techniques et financiers du traitement de sol, ainsi que son apport environnemental avec la notion de Developpement Durable.
Vigilancia epidemiológica de la hepatitis B en España. Años 1997 a 2008

Se ha realizado un estudio epidemiologico descriptivo de la incidencia y mortalidad por hepatitis B en Espana con datos desde 1997 a 2008. Se han utilizado como fuentes de informacion el Sistema de Enfermedades de Declaracion Obligatoria y el Sistema de Informacion Microbiologica, ambos integrados en la Red Nacional de Vigilancia Epidemiologica (RENAVE) junto con otras fuentes complementarias como son el Conjunto Minimo Basico de Datos (Morbilidad Hospitalaria) y la Estadistica de Causa de Muerte.
Perinatal Risk Factors and ADHD in Children and Adolescents: A Hierarchical Structure of Disorder Predictors

Objective: The aim of the study was to hierarchically assess the predictive power of low and high birth weight, pre-term and post-term birth, and low Apgar score as the risk factors for ADHD. Method: The data of 132 boys diagnosed with ADHD and 146 boys from control group, aged 6 to 18 years, have been analyzed. The boys were categorized according to term of birth, birth weight, and Apgar score. CART method (Classification and Regression Trees) was used for assessment of the relationship between perinatal factors and the risk of ADHD. Results: Low Apgar score (21.97% vs. 13.01%) and post-term birth (12.12% vs. 0.68%) were more frequent in the sample than in the control group. CART method additionally indicated low birth weight as associated with the risk of ADHD. Among analyzed risk factors, Apgar score had the highest predictive value. Conclusion: The decreased Apgar score is the most important perinatal risk factor of ADHD. Research results also indicated a high significance of post-term birth in predicting the disorder.
Apuração de custos no manejo da produção leiteira: uma análise comparativa entre o sistema tradicional e o sistema freestall

Este estudo objetiva comparar os custos e a produtividade na producao leiteira de dois metodos de producao: o sistema tradicional e o sistema de confinamento denominado freestall. A metodologia utilizada na pesquisa caracteriza-se como estudo de caso comparado, de natureza exploratoria e analise qualitativa. O estudo dos casos ocorreu em duas propriedades rurais que produzem leite, localizadas no Oeste de Santa Catarina, sendo uma no sistema de manejo tradicional (pastagem em forma de piquetes) e outra no sistema de confinamento (freestall). A coleta dos dados ocorreu no mes de janeiro de 2014, com o preenchimento de planilhas eletronicas contendo dados referentes ao imobilizado, fluxo de caixa, receita de vendas, custos de producao e produtividade. A partir da analise dos dados, constatou-se que o sistema freestall apresenta margem de lucro 8,55% superior no litro do leite, ocasionado principalmente pela maior produtividade de aproximadamente 78,8%, compensando a diferenca de custos de 13,57% maior que o sistema tradicional.
Ferrochelatase from Rhodopseudomonas sphaeroides: substrate specificity and role of sulfhydryl and arginyl residues

Purified ferrochelatase (protoheme ferrolyase; EC 4.99.1.1) from the bacterium Rhodopseudomonas sphaeroides was examined to determine the roles of cationic and sulfhydryl residues in substrate binding. Reaction of the enzyme sulfhydryl residues with N-ethylmaleimide or monobromobimane resulted in a rapid loss of enzyme activity. Ferrous iron, but not porphyrin substrate, had a protective effect against inactivation by these two reagents. Quantitation with 3H-labeled N-ethylmaleimide revealed that inactivation required one to two sulfhydryl groups to be modified. Modification of arginyl residues with either 2,3-butanedione or camphorquinone 10-sulfonate resulted in a loss of ferrochelatase activity. A kinetic analysis of the modified enzyme showed that the Km for ferrous iron was not altered but that the Km for the porphyrin substrate was increased. These data suggested that arginyl residues may be involved in porphyrin binding, possibly via charge pair interactions between the arginyl residue and the anionic porphyrin propionate side chain. Modification of lysyl residues had no effect on enzyme activity. We also examined the ability of bacterial ferrochelatase to use various 2,4-disubstituted porphyrins as substrates. We found that 2,4-bis-acetal- and 2,4-disulfonate deuteroporphyrins were effective substrates for the purified bacterial enzyme and that N-methylprotoporphyrin was an effective inhibitor of the enzyme. Our data for the ferrochelatase of R. sphaeroides are compared with previously published data for the eucaryotic enzyme.
Evidence‐based management of poor ovarian response

Poor ovarian response is not infrequent and represents one of the major therapeutic challenges in in vitro fertilization. Although several tests have been proposed, which aim at predicting poor response to ovarian stimulation, available data are conflicting regarding their accuracy and clinical usefulness. Even though several therapeutic approaches have been explored, a single effective strategy has not yet been established. One of the major limitations of interpreting the relevant literature is the wide variability in the definitions used for poor ovarian response. Regarding the interventions that have been proposed to improve the probability of pregnancy in poor responders, limited evidence from relevant randomized controlled trials suggests that addition of growth hormone during ovarian stimulation, as well as performing embryo transfer on day 2 instead of day 3, might be beneficial. Further randomized control trials are warranted to reliably determine which would be the best approach for treating poor ovarian response.