Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of OFD1 in the Pathogenesis of Polycystic Kidney Disease

Oral-facial-digital syndrome type1 (OFD1) is an inherited disorder caused by expression of mutant OFD1 protein and results in abnormalities in facial and limb development and polycystic kidney disease that resembles Autosomal Dominant Polycystic Kidney Disease (ADPKD). The similarities in renal disease pathogenesis in patients with OFD1 and ADPKD suggest that the proteins implicated in these diseases, OFD1 and the polycystins, respectively, function on a common pathway in the affected cell types. This calls for an investigation to uncover the mechanism by which OFD1 contributes to polycystic kidney disease pathogenesis, which remains unknown. This thesis details for the first time the assembly of a ciliary signaling microdomain containing OFD1, the polycystins, the epidermal growth factor receptor (EGFR), and the domain organizing flotillin
Wireless remote patient monitoring on general hospital wards

A novel approach which has potential to improve quality of patient care on general hospital wards is proposed. Patient care is a labour-intensive task that requires high input of human resources. A Remote Patient Monitoring (RPM) system is proposed which can go some way towards improving patient monitoring on general hospital wards. In this system vital signs are gathered from patients and sent to a control unit for centralized monitoring. The RPM system can complement the role of nurses in monitoring patients’ vital signs. They will be able to focus on holistic needs of patients thereby providing better personal care. Wireless network technologies, ZigBee and Wi-Fi, are utilized for transmission of vital signs in the proposed RPM system. They provide flexibility and mobility to patients. A prototype system for RPM is designed and simulated. The results illustrated the capability, suitability and limitation of the chosen technology.
Embedding corporate social responsibility into the organizational culture

This study emphasizes on the new growing interest in the field of Corporate Social Responsibility (CSR) by explaining how organizations embed CSR into their organizational culture. Hitherto research on CSR mainly focuses on the CSR practices and its motivations leaving the process of how to cultivate CSR as a work culture in its infancy. However scholars are now emphasizing the need to bridge the gap between the two literatures to ensure a proper CSR integration guideline for long term sustainability towards its stakeholders and ultimately a strong organizational culture. This research therefore adopts a qualitative method using a multiple case study approach to explore how Malaysian firms embed CSR and the challenges encountered. Moreover, this research overcome the “westernization” of CSR studies by injecting an eastern perspective; a developing nation.
Improved Client Satisfaction: A Strategic Approach in the Construction Sector

Client satisfaction has widely been recognised by researchers as one of the key challenges for quality improvement in the construction industry. It is a vital factor in the development and management of the construction process, as well in the creation of efficient company-client relationship. In addition, client satisfaction is a catalyst for client retention which is a success strategy for any organisation. This paper presents a novel theoretical framework for client satisfaction evaluation and assessment. It involves an integrated approach that considers the entire supply chain of a construction project as a tree structure and each member of that tree as an intelligent agent. Each agent will have processes and client satisfaction attributes associated with it. Relationships and interactions of the agents and how these affect the overall satisfaction levels of a single project, are analysed based on current practices in client satisfaction.
People with intellectual disability from culturally diverse backgrounds.

The multicultural nature of Australian society creates a need for occupational therapists to become aware of the issues facing people from culturally diverse backgrounds. People with intellectual disability from culturally diverse backgrounds may experience a ‘double disadvantage’ due to issues of their culture and their disability. This research aimed to identify the experiences, issues and strategies used by occupational therapists working with people with intellectual disability from culturally diverse backgrounds. A semistructured group interview and three individual interviews were conducted with occupational therapists from both metropolitan and rural locations in Queensland. It was found that communication and residential services present some unique issues for people with intellectual disability from culturally diverse backgrounds. Strategies suggested by therapists to address a range of issues are listed. Implications for occupational therapy are discussed, and suggestions for future research are provided.
The KIMONO-study: on the development of renal injury in children with a solitary functioning kidney

Congenital anomalies of the kidney and urinary tract are the major cause of end-stage renal disease in childhood. Children with a solitary functioning kidney form an important sub-group of congenital anomalies of the kidney and urinary tract patients, and a significant fraction of these children is at risk for progression to chronic kidney disease. However, challenges remain in distinguishing patients with a high risk for disease progression from those patients without a risk for disease progression. Although it is hypothesized that glomerular hyperfiltration in the lowered number of nephrons underlies the impaired renal prognosis in the solitary functioning kidney, the high proportion of ipsilateral congenital anomalies of the kidney and urinary tract in these patients may further influence clinical outcome. Pathogenic genetic and environmental factors in renal development have increasingly been identified, and may play a crucial role establishing a correct diagnosis and prognosis for these patients. With fetal ultrasound now enabling prenatal identification of individuals with a solitary functioning kidney, an early evaluation of risk factors for renal injury would allow for differentiation between patients with and without an increased risk for chronic kidney disease. This review describes the underlying causes and consequences of the solitary functioning kidney from childhood together with its clinical implications. Finally, guidelines for follow-up of solitary functioning kidney patients are recommended. Clinical implications of the solitary functioning kidney 11
El Aprendizaje Cooperativo, una metodología activa para la educación del siglo XXI: una revisión bibliográfica

Los cambios experimentados en las ultimas decadas en las sociedades industrializadas nos han llevado hacia una desconexion paulatina con el entorno, de falta de relacion tanto con la naturaleza como con las personas que lo habitan, conduciendonos hacia un horizonte que, para muchos, resulta preocupante. A pesar de esta realidad, en el mundo laboral se exigen, cada vez con mas frecuencia, competencias de tipo colaborativo que favorezcan las relaciones interpersonales. Por ello, la escuela, como uno de los agentes responsables en el desarrollo de competencias en el alumnado, se ha visto implicada en un proceso de transformacion para adaptarse a los nuevos retos de la sociedad actual. Uno de estos cambios se materializa en la incorporacion de metodologias activas que conciben el aprendizaje como un proceso activo y dinamico en el que el alumnado se convierte en protagonista del mismo. El Aprendizaje Cooperativo (AC) constituye una metodologia activa en la que los/las estudiantes trabajan en grupos reducidos para maximizar su aprendizaje, favoreciendo el desarrollo de su competencia social, la inclusion y la reduccion del acoso escolar. En el presente trabajo se realiza una revision de publicaciones desarrolladas en los ultimos diez anos sobre las principales aportaciones del AC ante los nuevos retos educativos de este siglo.
Xylitol für die Kariesprävention - einige praktische Aspekte und Richtlinien

A single reel with magnetic tape wound thereon is housed in a case. A restraining member, for restricting rotation of the reel by moving toward or away from the reel, is urged in a restraining direction by an urging member. The pushing-up portions of a releasing member are inserted into the through holes bored in the reel gear of the reel 2 so that the lower ends can abut a driving gear. The releasing member moves the restraining member in a releasing direction by moving according to the chucking operation of drive-side rotation drive means. In this manner, reel-rotation restraining means allows rotation of the reel when being used and restricts the rotation when not being used. In this construction, each of the through holes is bored between the tooth edges of the reel gear so that the releasing member can perform a reliable releasing operation.
Utilization of mHealth Services in Dhamrai Upazila of Dhaka District, Bangladesh

Purpose: The adoption and use of mHealth is considered as an effective intervention to improve health sector performance in developing countries across the world. Yet mHealth is in the early stage of its implementation in many countries. This study aims to identify the patterns, extent, motivations, and problems of mHealth applications in Bangladesh. Methods: The study was done in Dhamrai Upazila of Dhaka district where 250 mobile-phone users were interviewed to identify their extent and reasons of using mHealth services. Based on literature review and focus group discussion in the study area, the research confined five dimensions or reasons for using mHealth services, six issues for motivational and discouraging factors each. Both descriptive and inferential statistics were used to analyze data using statistical software STATA. Findings: Calling doctor’s private office is top ranked mHealth application. In this connection, 38 percent respondents used at least four types of mHealth applications among five dimensions and 30 percent respondents used all types of mHealth applications. On an average, respondents used near about four types of application where the mean application is3.82 out of 5. Hypothesis testing result shows that male’s mHealth application is higher than that of female. Again, average mHealth application of extended family is higher than that of nuclear family. Both findings are statistically significant at 1 percent level. Regarding the motivational factor of using mHealth application, employed group has ranked time saving’ and unemployed group has ranked ‘accessibility from remote area’ as the most motivational factor. On the other hand, both groups have ranked ‘not reaching focal person timely’ as the most discouraging factor of adopting mHealth. Spearman’s rank correlation coefficient reports that, between employed and unemployed group, there exist77 percent resemblance in benefit rank and 94 percent resemblance in problem rank. Proper regulation is essential to have proper coordination among health service providers, seekers and telecommunication service providers.
Current Concepts in Uveal Melanoma

Preface: Jager, M.J. Desjardins, L. Kivela, T. Damato, B.E. Diagnosis of Uveal Melanoma: Kivela, T. Treatment Selection for Uveal Melanoma: Damato, B.E. Ruthenium-106 Brachytherapy: Pe'er, J. Treatment of Uveal Melanoma by Accelerated Proton Beam: Desjardins, L. Lumbroso-Le Rouic, L. Levy-Gabriel, C. Cassoux, N. Dendale, R. Mazal, A. Delacroix, S. Sastre, X. Plancher, C. Asselain, B. Stereotactic Photon Beam Irradiation of Uveal Melanoma: Zehetmayer, M. Local Resection of Uveal Melanoma: Damato, B.E. Biopsies in Uveal Melanoma: Midena, E. Parrozzanl, R. Analysis of Intraocular Biopsies: Coupland, S.E. Antiangiogenic Therapy in Uveal Melanoma: el Filali, M. van der Velden, P.A. Luyten, G.P.M. Jager, M.J. Immunotherapy of Uveal Melanoma: Bosch, J.J. Genetic Determinants of Uveal Melanoma: Couturier, J. Saule, S. Therapeutic Options in Metastatic Uveal Melanoma: Mariani, P. Servois, V. Piperno-Neumann, S.
Long-term sickness absence and disability pension award as consequences of common mental disorders. Epidemiological studies using a population-based health survey and official ill health benefit registries

The common mental disorders anxiety and depression are widespread in the population and will affect 1 in 4 adults at least once during their lifetime. Due to high prevalence of common mental disorders within official benefit statistics, the contribution from these conditions on sickness absence and ill health retirement in the population is increasingly recognised. Sickness absence and ill health retirement rates have increased dramatically across the western world since the 1980s, and these high rates place enormous burdens on public expenditures. Sickness absence and ill health retirement may also have dire consequences for the individuals affected. In order to prevent and reduce sickness absence and ill health retirement, knowledge about causes and mechanisms is essential. These causes and mechanisms can not be identified using mere official benefit statistics or cross-sectional studies. The role of common mental disorders as risk factors for sickness absence and ill health retirement has only been examined in a handful of studies, with relatively short follow-up. Further, few high quality longitudinal and population-based studies have examined whether common mental disorders are associated with specific sickness absence and ill health retirement patterns, such as frequent recurrence and long duration of sickness absence, or early ill health retirement. Linking information from the epidemiological Hordaland Health Study (HUSK), conducted from 1997 to 1999, with data from official and comprehensive registries over sickness benefits and disability pension award (FD-Trygd) in the period 1997 to 2004, the aim of the present PhD project was to examine the long-term consequences and burden of common mental disorders on sickness absence and ill health retirement in the general population. In Paper 1, the aim was to examine the prospective associations between common mental disorders and long-term sickness absence. Common mental disorders were found to be long-lasting risk factors for sickness absence, with detectable effects up to 4 years after baseline measurements. Common mental disorders were particular strong risk factors for very long duration and frequent recurrence of sickness absence. Comorbid anxiety and depression showed the strongest associations with the different
The Estimation of Production Function and Technical Efficiency Shallot Farming

Shallot is one of the potential horticultural commodities. The purpose of this study is to estimate the production function and efficiency of shallot farming. The method used in the study is the estimation of production functions using stochastic frontier. The data used in this study were shallot production (kg), harvested area (m2), labor used (HOK), use of seeds (kg), fertilizer (kg), pesticides used (kg), sourced from SHR2014 which conducted by the Central Statistics Agency. In the estimation process, all variables are transformed by natural logarithms. The results showed that the estimation of the function of shallot production for both the dry season and the wet season with independent variables included harvested area, labor, seeds, fertilizers, and significant pesticides in the model, so that formed model was valid for further use. The average technical efficiency of shallot farming in the dry and wet season is 0.6626 and 0.6627, respectively, which means that in general, shallot farming in Indonesia is not efficient on the technical side. That is, there are indications that the optimal processing technology of production inputs in the business has not been carried out optimally.
Model of Intellectual Capital and Locus of Control on the Performance of Public Sector Internal Auditors Through Professional Commitment

The development of a paradigm towards good governance requires government officials who are responsive to bureaucratic reform demands by changing ways of working and behavior characterized by a high level of performance, accountability, transparency, clean from corruption, collusion and nepotism. The purpose of this research is to develop the model of Intellectual Capital and Locus of Control to improve the performance of Public Sector Internal Auditors through professional commitment. The benefits of this research are expected to contribute and respond to various problems in the implementation of organizational governance in the field of supervision through strengthening performance-based internal auditors' behavior so that they are able to work objectively and independently in investigations for preventive prevention of practices fraud. The results of the study provide an overview of intellectual capital (human capital, organizational capital and consumer capital) and locus of control both internally and externally affect the strengthening of professional commitment (affective, continuous, normative) and have implications for the high performance of internal public sector auditors. The relationship is illustrated in the path diagram model of 30 Government Internal Supervisors in the district / city inspectorate in West Java Province.
The development of short food supply chain for locally produced honey

PurposeThe development of the short food supply chain (SFSC) is one of the issues of the current agri-food systems. Consumers are re-connecting the food they eat with the farming process and are increasingly asking for fresh, seasonal and traceable food products from known producer source. The purpose of this paper is to analyse consumers’ opinions towards the SFSC and willingness to pay (WTP) for local honeys in Mar del Plata, Argentina before and after a hedonic evaluation test.Design/methodology/approachIn an incentive compatible approach, using real purchasing scenarios, two non-hypothetical discrete choice experiments were applied, accounting for the impact of the SFSC understanding and hedonic evaluation on consumers’ WTP.FindingsResults showed that consumers’ WTP, a premium for local honey products, is conditioned to specific quality cues and the global sensory acceptance. Consumers with high level of agreement with the social and environmental roles of the SFSC were more quality demanding and exhibited higher WTP towards the locally produced honeys. The development of local market by re-connecting producers and consumers, allowing for in-site tasting, has a strong implication for the structure of the honey added-value chain due to the potential role that may play in satisfying consumers’ preference and needs.Originality/valueThe authors measured consumers’ opinions towards the SFSC and analyse their impact on consumer WTP for honey product by including real purchasing scenarios and hedonic evaluation test, to reduce the hypothetical bias of the traditional surveys. Questionnaires were completed in a controlled laboratory environment for with real product and real money.
The Role of Proactiveness as a Mediatore Between Organizational-Stakeholders Relationship and Smes Performance

This study examines the mediating role of proactiveness between organizational-stakeholders relationship and performance of small and medium enterprises (SMEs). Cluster sampling method and questionnaire were used to collect data from 150 SMEs in Tehran. SmartPLS 3.0 was utilized to analyze the measurement and structural model. The survey outcomes revealed that organizational-stakeholders relationship had an indirect effect on performance through proactiveness. The results also indicated a positive links for organizational-stakeholders relationship and proactiveness. This research is one of the few attempts that have addressed the importance of proactiveness as the key mechanisms to transform the advantages of organization-stakeholder relationship to enhance performance.Scope: This research is beneficial for entrepreneurs who wish to learn about the specific resources significant for venture growth, to devise effective strategies to expand their relationship with stakeholders. It can be concluded that accessing the full range of resources via stakeholders is the key success factor for proactivness and firm performance.
Considerações sobre a Modelagem Estocástica dos Coeficientes do Algoritmo Adaptativo IAF-PNLMS

—This paper presents a stochastic model for the adaptive coefficient evolution of the individual-activation-factor proportionate normalized least-mean-square (IAF-PNLMS) adaptive algorithm. For such, a new eigendecomposition procedure for the matrices arising from the expected value calculus involved in the model development is used; in addition, the algorithm gain matrix is assumed time-variant. As a consequence, the proposed model predicts both transient and steady-state phases of the mean behavior of the adaptive coefficient vector. Through simulation results, the accuracy of the proposed model as well as the key approximations used are verified.
Minority Success in Non-Majority Minority Districts: Finding the “Sweet Spot”

Abstract Though African-American and Latino electoral success in state legislative and congressional elections continues to occur almost entirely in majority-minority districts, minorities now have new opportunities in districts that are only 40–50% minority. This success can primarily be explained in terms of a curvilinear model that generates a “sweet spot” of maximum likelihood of minority candidate electoral success as a function of minority population share of the district and the proportion of the district that votes Republican. Past racial redistricting legal challenges often focused on cracking concentrated racial minorities to prevent the creation of majority-minority districts. Future lawsuits may also follow in the steps of recent successful court challenges against racially motivated packing that resulted in the reduction of minority population percentage in a previously majority-minority district in order to enhance minority opportunity in an adjacent non-majority-minority district.
Multisensory design as a tool for emotional regulation: enabling users to communicate emotions through senses

The complex nature of emotions poses challenges for those struggling to manage them. Thus, a broader spectrum of regulatory strategies needs to be developed. The ways in which product design contributes to emotional regulation have been scarcely investigated. Yet it is argued here that multisensory design can provide new ways of emotional communication by enabling individuals to use senses to express inner states non-verbally. The paper tries to draw the connection between emotions, senses and product design. It then presents the results of four case studies evaluating expressive sensory features of various objects designed by contemporary product designers. In addition, the survey conducted among students at Oslo Metropolitan University and Manchester School of Architecture reveals basic user preferences in expressing emotions through senses. The findings suggest that in order to facilitate emotional expression through objects, opportunities for contextualization and variety of choice should be provided. Furthermore, expression of a negative emotion is in many cases less effective than distraction and, therefore, should not be the only goal in the design process. Most of the respondents reported experiencing difficulties in emotional expression. Although few use objects in displaying emotions, many expressed interest in alternative ways to communicate feelings. The recommendations for using senses in designing for emotional regulation, which can be addressed in teaching practices in design and other relevant fields, are compiled based on the obtained results.