Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of Brain MRI after Deep Brain Stimulation Hardware Implantation

ABSTRACT The objective of this study was to examine the experience with and safety of brain 1.5 Tesla (T) magnetic resonance imaging (MRI) in deep brain stimulation (DBS) patients. This was a retrospective review of brain MRI scanning performed on DBS patients at the University of Kansas Medical Center between January 1995 and December 2007. A total of 249 DBS patients underwent 445 brain 1.5 T MRI scan sessions encompassing 1,092 individual scans using a transmit-receive head coil, representing the cumulative scanning of 1,649 DBS leads. Patients with complete implanted DBS systems as well as those with externalized leads underwent brain imaging. For the majority of scans, specific absorption rates localized to the head (SARH) were estimated and in all cases SARH were higher than that specified in the present product labeling. There were no clinical or hardware related adverse events secondary to brain MRI scanning. Our data should not be extrapolated to encourage MRI scanning beyond the present labeling. Rather, our data may contribute to further defining safe MRI scanning parameters that might ultimately be adopted in future product labeling as more centers report in detail their experiences.
Study of Relationship between Debt, Investment and Output Market Competition Based on Bankruptcy Costs

Drawing on Brander and Lewis' train of thought in reaserch, we provide a new model concerning the impact of bankruptcy-cost-based liability on investment in the Cournot oligopolistic competitive environment. We have found out that in Cournot oligopolistic competition environment, the impact of debt on investment depends on the type of product competition strategy and influence of environmental changes on the marginal returns and cross marginal returns of the firm's output and investment respectively.
Modeling bond wires for millimeter wave RFIC design

This paper discusses how bond wires can be accurately modeled for circuits operating at several 10 GHz. To obtain exact results a more sophisticated model than the commonly-used inductor with around 0.8 nH/mm is required. An edge-based multiple conductor transmission line (mtline) model is presented, and it is demonstrated how its parameters can be extracted from EM simulations. A comparison of the mtline model with a lumped components model demonstrates the advantages of the mtline approach.
Effects of Type 1 Diabetes Risk Alleles on Immune Cell Gene Expression

Genetic studies have identified 61 variants associated with the risk of developing Type 1 Diabetes (T1D). The functions of most of the non-HLA (Human Leukocyte Antigen) genetic variants remain unknown. We found that only 16 of these risk variants could potentially be linked to a protein-coding change. Therefore, we investigated whether these variants affected susceptibility by regulating changes in gene expression. To do so, we examined whole transcriptome profiles of 600 samples from the Type 1 Diabetes Genetics Consortium (T1DGC). These comprised four different immune cell types (Epstein-Barr virus (EBV)-transformed B cells, either basal or after stimulation; and cluster of differentiation (CD)4+ and CD8+ T cells). Many of the T1D-associated risk variants regulated expression of either neighboring (cis-) or distant (trans-) genes. In brief, 24 of the non-HLA T1D variants affected the expression of 31 nearby genes (cis) while 25 affected 38 distant genes (trans). The effects were highly significant (False Discovery Rate p < 0.001). In addition, we searched in public databases for expression effects of T1D single nucleotide polymorphisms (SNPs) in other immune cell types such as CD14+ monocytes, lipopolysaccharide (LPS) stimulated monocytes, and CD19+ B cells. In this paper, we review the (expression quantitative trait loci (eQTLs) associated with each of the 60 T1D variants and provide a summary of the genes impacted by T1D risk alleles in various immune cells. We then review the methodological steps involved in analyzing the function of genome wide association studies (GWAS)-identified variants, with emphasis on those affecting gene expression. We also discuss recent advancements in the methodologies and their advantages. We conclude by suggesting future study designs that will aid in the study of T1D risk variants.
Low-Complexity Detection Exploiting Subcarrier Correlation in Multi-Layer STBC OFDM

We propose a multi-layer space-time block coded orthogonal frequency division multiplexing (multi-layer STBC OFDM) scheme. It combines the spatial diversity and spatial multiplexing in order to exploit the benefits of both techniques. The transmit antennas are divided into several layers and each layer is encoded by STBC. The antennas transmit OFDM signals in order to deal with frequency-selective fading channels. In addition to exhaustive detection scheme which applies the same detection at each subcarrier independently, we exploit the subcarrier correlation to develop a subcarrier-grouping based detection scheme (SGD scheme). The subcarriers bound into the same group share the same detection parameters, e.g., layer detection order which is obtained at the center subcarrier of that group. This feature can significantly reduce the detection complexity with very small performance loss. The simulation results show that compared with exhaustive detection scheme, the proposed SGD scheme is capable of reducing 36.13% complexity with less than 1.0 dB performance loss for 4times4 system, and reducing 52.44% complexity with about 1.3 dB performance loss for 6times6 system, respectively
A model of the Internet as creative destroyer

The extent to which a technological change is a creative destroyer is of interest to entrepreneurs who can exploit the opportunity and to incumbents who must defend their existing competitive advantages from the change. In the face of a technological change, an important question is: To what extent is it a creative destroyer? In this paper, we offer a model for exploring the depth and breadth of creative destruction from the Internet and the implications for wealth creation and competitive advantage. We apply the model to three groups of industries, each of which rests on one of Thompson's three categories of organizational technologies: long-linked; mediating; and intensive. The application suggests that incumbents in all industries should experience some erosion of competitive advantage. Industries with predominantly mediating technologies should experience creative destruction. Those with intensive technologies should experience more erosion of competitive advantage than those with long-linked technologies.
Detection of M2 macrophages and colony‐stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors

Tumor‐associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and metastasis by producing various mediators. Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors. The purpose of the present study was therefore to present results on macrophage differentiation in human ovarian serous and mucinous epithelial tumors. The method focused on immunostaining of paraffin‐embedded tumor samples. Almost all macrophages infiltrating tumor tissues expressed CD163 and CD204, indicating the phenotypic shift toward M2 macrophage. The numbers of CD68‐positive macrophages as well as of CD163‐ and CD204‐positive macrophages in borderline and malignant tumors were significantly higher than in benign tumors. They correlated well with histological gradient of malignancy. Macrophage colony‐stimulating factor (also known as colony‐stimulating factor; CSF‐1), which is one of the cytokines considered to induce TAM to polarize toward an M2 phenotype, was then evaluated. CSF‐1 expression in malignant tumor cells was significantly higher than that in benign tumor cells and correlated with histological malignancy. These results suggest that CSF‐1 derived from tumor tissues induces macrophages to shift toward the M2 phenotype, which is considered to promote tumor growth.
Effects of isometric exercises done with a belt upon the physical fitness status of students in required physical education classes.

Abstract Students (N = 104) enrolled in four low fitness, one middle fitness, and one high fitness class in basic physical education classes at the University of Connecticut participated in a 4-week program of isometric exercises done with an adjustable nylon belt which was stabilized against various body segments. Low, middle, and high fitness classes were compared in the amount of improvement made in the 5 items in which significant gains had been made. The MWF classes which did 30 min. of isometric exercises for 12 class meetings were compared to the TTh classes which met for 8 class meetings and which did the same isometric exercise program and in addition did stretching exercises and ran a mile. When all groups were treated together, mean gains of 1.1 in. in the vertical jump, . 74 sec. in the agility run, . 17 sec. in the 30-yd. dash, 151.9 lb. in the leg lift, and 57.0 lb. in the back lift were made. These were all significant at the 0.005 to the 0.0005 level. Small but significant gains were made in.
Transcription of 70S RNA by DNA polymerases from mammalian RNA viruses

DNA polymerases purified by the same procedure from four mammalian RNA viruses, simian sarcoma virus type 1, gibbon ape lymphoma virus, Mason-Pfizer monkey virus, and Rauscher murine leukemia virus are capable of transcribing heteropolymeric regions of viral 70S RNA without any other primer. In this reconstituted system the enzymes from simian sarcoma virus type 1, Mason-Pfizer monkey virus, and Rauscher murine leukemia virus transcribe viral 70S RNA almost as efficiently as the DNA polymerase from the avian myeloblastosis virus, but gibbon ape lymphoma virus DNA polymerase is approximately three-to fivefold less efficient. Although there is a substantial difference among the sizes of these DNA polymerases (160,000 daltons for the avian myeloblastosis virus enzyme, 110,000 daltons for the Mason-Pfizer monkey virus enzyme, and 70,000 daltons for the mammalian type C viral polymerases), the ability to transcribe viral 70S RNA is a characteristic common to these enzymes.
Learning action sequences for decision-making in home automation systems

Knowing the behavior habits of the individuals can contribute to decision making in human-centered environments. This work presents a learning model within the IntelliDomo project, a system which is able to learn the individuals' habits and make decisions in order to automatically generate production rules that anticipate the users' frequent and periodic activities. The learning layer incorporates new features such as the detection of action sequences, since users' habits can be better defined if they are related to chained actions, creating action-action relationships.
The Future of Research in Multiple Sclerosis.

Over the past 2 decades, advances in immunology, imaging, and experimental therapeutics have led to dramatic progress in understanding and treating multiple sclerosis (MS). Currently, there are more than 12 US Food and Drug Administration–approved therapies for MS, with more in development. Magnetic resonance imaging has been shown to be useful both in screening novel antiinflammatory therapies in phase 2 trials and in identifying patients with suboptimal treatment response in clinical practice. Pharmacologic and other treatment approaches have demonstrated effectiveness in alleviating symptoms and compensating for disability. Despite these advances, there remain many critical needs in understanding and treating MS.
Using the Alzheimer’s Association Web Site to Improve Knowledge of Alzheimer’s Disease in Health Care Providers

Background: The purpose of the current study was to investigate whether an informative Web site is effective at producing higher scores for an individual’s knowledge of Alzheimer’s disease (AD) relative to those who do not visit a Web site. Methods: A total of 552 participants completed the study on Amazon’s Mechanical Turk; half were randomly assigned to visit alz.org, while a control group did not. Both groups were given the AD Knowledge Scale (ADKS) to assess their knowledge of AD. Results: Participants who visited alz.org scored significantly higher on the ADKS than those in the control group. Participants who were health care workers demonstrated higher scores than others in the experimental condition. Findings indicate that the Alzheimer’s Association Web site is effective at producing higher scores for AD knowledge relative to no Web site at all and that it is especially helpful for health care workers compared to those who are not health care workers.
Voltage feed-forward performance in stationary reference frame controllers for wind power applications

In order to improve the connected current and the response speed of the controller, stationary reference frame control strategy with proportional resonant (P-R) controller due to its high dynamic and good harmonic compensation performance characteristics was already used in many different DG applications. This paper introduced an additional stationary reference frame control strategies with voltage feed-forward method. By using this method, both the quality of grid connected current and the dynamic performance are improved, which also validated by experiments.
LMI-based adaptive reliable H∞ static output feedback control against switched actuator failures

ABSTRACT This paper investigates the H∞ static output feedback (SOF) control problem for switched linear system under arbitrary switching, where the actuator failure models are considered to depend on switching signal. An active reliable control scheme is developed by combination of linear matrix inequality (LMI) method and adaptive mechanism. First, by exploiting variable substitution and Finsler's lemma, new LMI conditions are given for designing the SOF controller. Compared to the existing results, the proposed design conditions are more relaxed and can be applied to a wider class of no-fault linear systems. Then a novel adaptive mechanism is established, where the inverses of switched failure scaling factors are estimated online to accommodate the effects of actuator failure on systems. Two main difficulties arise: first is how to design the switched adaptive laws to prevent the missing of estimating information due to switching; second is how to construct a common Lyapunov function based on a switched estimate error term. It is shown that the new method can give less conservative results than that for the traditional control design with fixed gain matrices. Finally, simulation results on the HiMAT aircraft are given to show the effectiveness of the proposed approaches.
The Relationship between RUNX3 Expression, Nursing Strategies and Nutritional Status in Elderly Patients with Advanced Gastric Cancer

Background: The aim of this study was to explore the relationship between nutritional status and expression of RUNX3 in gastric cancer cells and to investigate the effects of nursing strategies on the nutritional status of elderly patients with advanced gastric cancer. Methods: Forty-eight elderly patients admitted at Affiliated Hospital of Qingdao University with advanced gastric cancer and 30 healthy controls were selected as subjects from 2014–15. The correlation between RNX3 gene expression and nutritional status of the gastric cancer patients was investigated. The patients with advanced gastric cancer who had low expression of RUNX3 gene were treated with holistic nursing while routine nursing was taken for those patients who had normal or high expression of RUNX3 gene. The nutritional statuses of these patients were evaluated after 3 months of nursing. After a follow-up of 1 year, the influence of different nursing methods on the survival time was evaluated. Results: Compared with normal gastric tissue, the expression of RUNX3 gene and protein in tissues of advanced gastric cancer were significantly decreased (P<0.01). Compared with patients with normal or high expressions of RUNX3, the nutritional statuses of advanced gastric cancer patients with low expressions of RUNX3 were lower (P<0.01). The nutritional statuses of patients with low expressions of RUNX3 were notably improved after holistic nursing, becoming equivalent to those with normal or high expression of RUNX3 who received routine nursing (P>0.05). The survival time of patients with low expression of RUNX3 who received holistic nursing were similar to patients with normal or high expression of RUNX3 who received routine nursing (P>0.05). Conclusion: RUNX3 is correlated with the occurrence and development of advanced gastric cancer. The low nutritional status of elderly advanced gastric cancer patients with low expressions of RUNX3 can be significantly enhanced by holistic nursing, thereby prolonging survival time.
Faculty Development in Geriatrics for Clinician Educators: A Unique Model for Skills Acquisition and Academic Achievement

As the size of the aged American population increases, so too does the shortage of trained providers in geriatrics. Educational strategies to train physicians at all levels of experience within adult medical and surgical disciplines are needed to complement fellowship training, given the small size of most academic faculties in geriatrics. This article describes a unique faculty development program that creates geriatrically oriented faculty in multiple disciplines. The Boston University Center of Excellence in Geriatrics (COE), funded by the John A. Hartford Foundation, has trained 25 faculty members. Four to six scholars enter the program each year and participate in the COE 1 day per week. Nine months are spent in four content modules—Geriatrics Content, Clinical Teaching, Evidence‐based Medicine, and Health Care Systems; 3 months are spent in supervised scholarly activities and clinical settings. A self‐report questionnaire and a structured interview were used to evaluate the outcomes of participation in the COE. The results from the first 4 years of the program are reported. The response rate was 83% for the self‐report questionnaire and 75% for the structured interview. The results indicate that the COE is effective in improving scholars' assessment and management of older patients. The structured interview revealed that the COE program promotes the integration of geriatrics into clinical teaching at the medical student and resident level. Participants also completed scholarly projects in geriatrics. This program effectively trains faculty scholars to better care for older adults and to teach others to do likewise.
One Dollar Workplaces: A Study of Informal Sector Activities in Magaba, Harare

In spite of the informal sector's role as a major 'employer' oflabour and source of income for many in Africa very little research has been done in this area: this paper reports on one study of informal sector operations in a specific urban location, Magaba, in Harare, Zimbabwe. The study concludes that while the informal sector can be seen as an 'employer of last resort' for some, a significant number of operators are committed to their informal sector enterprises and would continue in them even if other options were open. The Magaba study highlights the operations of the informal sector as distinctly heterogeneous with a stratification within the sector that appears to be related to tenure of workplace and type of economic activity. These factors imply the necessity for differential treatment of the various subgroups of informal operators and unemployed in terms of local and national policy
Ionic currents in the guinea‐pig taenia coli.

Short segments of portions of taenia coli of the guinea‐pig averaging 54 mum X 219 mum X ca. 200 mum have been studied by a double sucrose‐gap voltage‐clamp technique. 2. The average total capacitance was 0‐4 muF, corresponding to approximately 10(4) cells, if a specific membrane capacitance of 3 muF/cm2 were assumed. 3. A significant resistance, averaging 11‐4omega, was in series with the membrane, and seriously limited the accuracy of the voltage control possible. 4. On depolarization, an early transient inward current was followed by a late maintained outwary current. 5. The late current was carried mainly by K+, because its direction could be reversed if the preparation were first depolarized in isotonic K2SO4 and held back to the original resting potential. 6. After appropriate corrections for residual capacitative and leakage currents, a reversal potential for the late current (Eb) was determined to be 15‐20 mV more negative than the natural resting potential. It was not affected by the amplitude or the duration of the activating voltage step, but could be changed by prolonged applications of holding current. 7. At rest, the ratio of PNa:PK was 0‐16:1; for Eb it was 0‐05:1. 8. The reversal potential for the transient early inward current (Ea) averaged 22 mV in Krebs‐bicarbonate solution, but was shifted to about 35 mV when the late current was first suppressed with tetraethylammonium ion. The shift suggested that there was some overlap of the early and late currents. 9. Reduction of [Na+]o to 50% of normal, or replacement of all Na+ with dimethyldiethanol ammonium ion and choline ion, failed to cause any significant shifts in the reversal potential of the early current or reduce the magnitude of the early current. 10. Reduction of [Ca2+]o to 0‐25 or 0‐1 of the normal caused shifts of the Ea toward the negative and reductions in the early current. These changes can occur without changes in the maximum chord conductance of the early current, such as might happen in ordinary Krebs‐bicarbonate solution, or in preparations which had been depolarized by prior treatment with isotonic K2SO4 and then held back to the original membrane voltage. 11. Increase of [Ca2+]o to 5 times normal increased the early inward current, and the maximum chord conductances of the early and late currents, but did not shift the Ea. 12. In preparations pretreated with TEA, increasing [Ca2+]o to 5 times normal shifted Ea toward 45 mV. 13. The various observations are interpreted to mean that the early current in the taenia coli is carried principally by influx of Ca2+, and not by Na+.