Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring the Identity and Relationship Experiences of Lesbian and Bisexual Women with Intellectual Disabilities

Women with intellectual disabilities who are attracted to other women have been largely neglected from research and remain a hidden and marginalised group in society. To date, a small body of literature has explored the experiences of people with intellectual disabilities who are lesbian, gay or bisexual (LGB); however, women with intellectual disabilities have featured either in very small numbers, or not at all. This research sought to address this gap and explore the specific experiences of women with intellectual disabilities who identify as LGB. The research aimed to gain insight into how women with intellectual disabilities described and understood their LGB identity, where they felt included and excluded in their day-to-day lives and if they felt supported in their expression of same-sex attraction. Six women with intellectual disabilities took part in semi-structured interviews, with four of the women participating in an additional photovoice interview. Data was analysed using thematic analysis, during which, three main themes were identified: ‘non-heterosexual identity as difficult’, ‘the impact of invisibility and difference’ and ‘visibility and a positive sense of self’. Participants described feeling isolated, invisible and excluded due to the stigma of having a disability and a minority sexuality. Indeed, the women described feeling judged and discriminated against because of their sexuality, but isolated and unaccepted by the non-disabled lesbian, gay, bisexual and transgender (LGBT) community. The participatory research method of photovoice, however, enabled participants to also present the areas of their lives where they felt loved, accepted and supported. Implications for future research are considered, as well as a consideration of what support is needed to help this marginalised, oppressed and hidden group in society.
Numerical and functional responses of wolves, and regulation of moose in the Yukon

Numerical and functional responses of wolves (Canis lupus) were studied in a 23,000 km2 area of the east-central Yukon. Populations of wolf, moose (Alces alces) and woodland caribou (Rangifer tarandus caribou) were increasing following intensive reduction of wolf numbers. Snow-tracking surveys and radiotelemetry studies indicate that the wolf population recovered to pre-reduction densities within 4 years. The area was colonized initially by young wolves that dispersed into vacant territories, and by packs that shlfted from the boundaries of the study area. Survival rates of wolves were the highest reported in the published literature. Pack splitting became more common as size of wolf packs increased. Dispersal rates were positively correlated to wolf densities. Wolf numerical response appeared to be tightly regulated by ungulate supply. Two hundred and ninety-one moose, 30 caribou and 1 mountain sheep (Ovis dalli) were found dead during my study. Wolves killed mainly young and old moose and most prey were not nutritionally stressed. Wolf predation was mainly additive mortality to both moose and caribou populations. Killing rates by 2 1 different wolf packs were studied during 45 periods in late winter. Kill rate of moose by wolves was negatively correlated with wolf pack size but was not correlated with moose density, prey searching rate, snow depth, observation rates, wolfiprey ratios, availability of alternate prey, or snowshoe hare abundance. Also, kill rate of moose calves by wolves was not correlated to wolf pack size, snow depth or calf availability each winter. Wolves in small packs had disproportionately higher kill rates on moose compared to wolves in large packs. Predation by wolves was the main factor limiting recruitment of both moose and caribou, and survival of adult moose. Wolf functional response was density-independent when moose were between 0.25 and 0.43 moose/km2. At lower moose densities, a decelerating type I1 wolf functional response best fit my data, but I could not determine if it is regulatory or anti-regulatory on moose. I combine data from other studies and show that wolf predation could regulate moose to a single low density equilibrium (0.12 moose/km2> in most wolf: moose systems in North America. My model indicates that bear predation and changes to moose habitat quality have little effect on the stable equilibrium point, where moose are the primary prey of wolves. My model also indicates that no unstable upper density boundary exists beyond which moose could escape the regulating effect of wolf predation. Wildlife managers should not expect permanent benefits for moose from temporary wolf reduction programs in relatively simple wolf: moose systems.
Community Violence Exposure, Experiential Avoidance and Depression in Chinese Adolescents

: This study aimed to investigate the link between community violence exposure, experiential avoidance and depression among Chinese adolescents. A total of 468 middle school students from China completed the Survey of Children’s Exposure to Community Violence, Acceptance and Action Questionnaire-Second Edition (AAQ-II) and Children’s Depression Inventory (CDI). The results suggested that the depression was positively correlated with the level of community violence exposure and experiential avoidance, and community violence exposure was positively correlated with experiential avoidance. Mediation analysis revealed that experiential avoidance partially mediated the association between exposure to community violence and depression. These results suggest that educators and parents can help adolescents prevent or reduce the happening of depression by reducing their risk of exposure to community violence and decreasing experiential avoidance.
Lipid peroxidation in biological systems

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Hereditary early-onset Parkinsonism : the role of the FBXO7 protein

textabstractParkinson’s disease (PD) is one of the most common neurodegenerative disorders, which affects ~1-2% of the population above the age of 60 years old. We identified pathogenic mutations in the FBXO7 gene in two families with early-onset, progressive parkinsonism and pyramidal tract dysfunctions. This finding provided the conclusive evidence that FBXO7 is the disease-causing gene in this newly-identified autosomal recessive form, which we termed PARK15. Very little was known about the two protein isoforms, which are predicted to be encoded by FBXO7, and nothing was known about their expression in the human brain. Here, we demonstrated the expression of these proteins in normal human cells and the consequences of mutations in cells derived from PARK15 patients. In parallel with the above-mentioned in vitro experiments, we also generated the first in vivo model of PARK15 by transient, morpholino-mediated knockdown of the homologous gene Fbxo7 in zebrafish. This model displayed both pathologic and behavioural hallmarks of human parkinsonism (dopaminergic neuronal loss and dopamine-dependent bradykinesia), representing therefore a valid tool for investigating the mechanisms of selective dopaminergic neuronal death. Moreover, the expression of FBXO7 proteins in the brain of normal human subjects and of PD patients was investigated. We observed widespread neuronal FBXO7 immunoreactivity throughout the brain regions, of note, the FBXO7 immunoreactivity was also detected in the Lewy bodies and Lewy neuritis, suggesting a role for FBXO7 proteins in the pathogenesis of Lewy-body pathology in the common (non-Mendelian) forms of synucleinopathies.
Cotton fertilization using PGPR Bacillus amyloliquefaciens FZB42 and compost: Impact on insect density and cotton yield in North Benin, West Africa

Abstract This work has compared the effects of the biofertilizer Bacillus amyloliquefaciens FZB42 with that of compost for cotton production. The population dynamics of pests and predators have been studied in order to check whether the use of both fertilization materials can contribute to pest management in cotton. Three treatments were considered: (i) dressing of seeds in rhizobacteria suspension, (ii) introduction of rhizobacterial suspension directly in the pocket, same time with the seeds, and (iii) fertilization with compost. The study was carried out in northwest Benin (West Africa). Results showed that cotton aphids, Aphis gossypii, pink bollworm, Pectinophora gossypiella, leaf roller, Sylepta derogata, and cotton bugs, Dysdercus sp. are the major insect pests encountered in the experimental plots. Cotton bollworm, Helicoverpa armigera, was present but under the economic threshold. The coccinellid predators, Cheilomenes spp. , occurred in the experimental plots and almost suppressed aphid proliferation. Other natural enemies such as chrysopids and ant species also occurred and probably contributed to maintain the cotton bollworm under the economic threshold. The treatment with seeds dressed with the rhizobacteria suspension yielded 39% more cotton compared to the compost fertilization. The use of both fertilization materials without application of chemicals can contribute to pest management in cotton.
Biochemical Correlations of Power Development and Metabolic Fuel Preferenda in Fish Hearts

Hearts from 16 species of fishes, including representatives of cyclostomes, elasmobranchs, and teleosts, were examined. As a biochemical index of maximal ATP demand, ATPase activity of crude homogenates of ventricular tissue was measured under conditions which optimize activity of myofibrils and inhibit nonphysiological mitochondrial F₁-ATPase by inclusion of oligomycin in the assay medium. The activities of nine additional enzymes from pathways of energy metabolism and concentration of myoglobin-an intracellular protein involved in storage and diffusion of oxygen-were measured. Of all possible pairwise regressions between these biochemical markers, only the relationships among ATPase, carnitine palmitoyltransferase (CPT), and hexokinase (HK) and between HK and phosphofructokinase (PFK) were significant. The inability of elasmobranch myocardium to catabolize fatty acid is confirmed. ATP yields calculated from HK and CPT and corrected to reflect physiological conditions of the tissue suggest that catabolism of either carbohydrate or fatty acid fuels can meet maximal energetic demands of the tissue. The range of power developments encompassed by hearts of ectothermic fishes, although substantial, has not resulted in selective expansion of capacity to oxidize one particular metabolic fuel.
Cinsel İstismara Uğrayan Çocuk ve Ergenlerin Kendine Zarar Verme, İntihar Davranışı ve Psikiyatrik Bozukluklar Açısından Değerlendirilmesi

Objective: It is now generally known that undergoing a sexual abuse may lead to self-destruction, suicide, post-traumatic stress disorder (PTSD), depression and dissociative disorders. Our study aims at determining the rate of self-destruction and suicide among children who had experienced sexual abuse and determining the rates of depression, PTSD and dissociative disorders and their relationships each other.Materials and Methods: The children aged 0-18 who had undergone sexual abuse and sent to Prevention of Child Abuse, Application and Research Center at Erciyes University between 01.01. 2011-31.12. 2011 to have a judicial report were analyzed retrospectively with regard to their age, sex, frequency of abuse, psychiatric diagnosis according to DSM IV-TR and leaving home or suicide behaviors. The children were made to complete Depression Scale for Children (CDI), Child Post-Traumatic Stress Reaction Index (RPTS-CS) and Dissociation Questionnaire (DIS-Q). Results: 556 cases were included in our research. There was suicide attempt in 24(4,3%) of them, 15 (2,7%) had the behavior of self-mutilation, 6 (1,1%) of them had the idea to commit suicide. In the scales, RPTS-CS was found significant for 33 (5,6%) cases. The score of the DIS-Q was found significant for 8 (1,6%) cases (>2,5). The mean score of the CDI was found significant for 42 (7,3%) cases (>19). Conclusion: It is not only important to follow up closely the children who had experienced sexual abuse and to protect their mental health, but also it is very important to keep them away from being a victim again and prevent to commit suicide and self-mutilation behaviors.
Genome evolution in Streptococcus pneumoniae

Streptococcus pneumoniae (the pneumococcus) is a bacterial pathogen responsible for >1.6 million annual deaths globally. Pneumococcal penicillin-resistance is conferred by acquisition of ‘altered’ penicillin-binding protein (pbp) genes. The first penicillin-nonsusceptible pneumococci were identified in the late 1960s. Global pneumococcal penicillin-nonsusceptibility rates rapidly increased in the 1980s/90s. Since 2000, protein-conjugate vaccines, targeting 7, 10 or 13 of the ≥94 different pneumococcal capsule types (serotypes), have been introduced in many countries. Following vaccine implementation there has been a decline in vaccine-type pneumococcal disease and an increase in non-vaccine-type disease. These epidemiological changes result from “serotype replacement” and/or “serotype switching”. The former describes the expansion of non-vaccine-type clones in the absence of vaccine-type pneumococci. The latter describes serotype change following recombination at the capsule polysaccharide synthesis (cps) locus. To fully understand how pneumococci respond to vaccine- and antibiotic-induced selective pressures, we must better understand the evolutionary history of this pathogen. This thesis describes the study of a global collection of 426 pneumococci, dated 1937 - 2007. Serotype, genotype and penicillin-susceptibility data were collected. Nucleotide sequences of three pbp genes (for 389 isolates) and whole-genome sequences (for 96 isolates) were also generated. The data demonstrated the long-term persistence of certain clones within pneumococcal populations, and that pbp and large-fragment (>30 kb) cps ± pbp recombination was occurring prior to both widespread antibiotic use and vaccine implementation. The data highlighted the promiscuous nature of the globally-distributed PMEN1 clone and its contribution to the spread of pneumococcal penicillin-resistance. PMEN1 also donated multiple, large regions (1.7 - 32.3 kb) of its genome to at least two un-related clones. Finally, six “Tn916-like” genetic elements, conferring resistance to non-penicillin antibiotics, were newly identified. These included two of the oldest ever described. These results provided a unique insight into the history of pneumococcal evolution and the importance of genetic recombination.
Harper's Illustrated Biochemistry

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Robust equilibrium control-measure policy for a DC pension plan with state-dependent risk aversion under mean-variance criterion

In reality, when facing a defined contribution (DC) pension fund investment problem, the fund manager may not have sufficient confidence in the reference model and rather considers some similar alternative models. In this paper, we investigate the robust equilibrium control-measure policy for an ambiguity-averse and risk-averse fund manger under the mean-variance (MV) criterion. The ambiguity aversion is introduced by adopting the model uncertainty robustness framework developed by Anderson. The risk aversion model is state-dependent, and takes a linear form of the current wealth level after contribution. Moreover, the fund manager faces stochastic labor income risk and allocates his wealth among a risk-free asset and a risky asset. We also propose two complicated ambiguity preference functions which are economically meaningful and facilitate analytical tractability. Due to the time-inconsistency of the resulting stochastic control problem, we attack it by using the game theoretical framework and the concept of subgame perfect Nash equilibrium. The extended Hamilton-Jacobi-Bellman-Isaacs (HJBI) equations and the verification theorem for our problem are established. The explicit expressions for the robust equilibrium policy and the corresponding robust equilibrium value function are derived by stochastic control technique. In addition, we discuss two special cases of our model, which shows that our results extend some existing works in the literature. Finally, some numerical experiments are conducted to demonstrate the effects of model parameters on our robust equilibrium policy.
TRPV4 deficiency protects myocardium following myocardial infarction and transverse aortic constriction (893.11)

Cardiac remodeling is triggered by a cascade of events following myocardial injury, including the differentiation of cardiac fibroblasts (CFs) into myofibroblasts. Myofibroblasts are hypersecretory and highly contractile cells, however, in excess, can lead to cardiac dysfunction and eventual heart failure. Recently, our lab has shown, in vitro, that TRPV4, a mechanosensitive ion channel, integrates mechanical and soluble signals to aid in the differentiation process of CFs. Our current study aims to investigate physiological role of TRPV4 during the remodeling process by subjecting wild type (WT) and TRPV4 knockout (KO) mice to myocardial infarction (MI) or transverse aortic constriction (TAC). Assessment of the post‐surgery survival and cardiac function found the TRPV4 KO mice to have improved survival rates and preserved ejection fraction. Cardiac fibrosis was examined using picrosirius red staining which revealed that the TRPV4 KO mice had significantly less fibrosis than their WT counterparts. Furthermore, a comparison of gene expression in the whole heart tissue allowed analysis of pro‐fibrotic genes, such as col1A2, α‐SMA, N‐FAT, TGF‐β1, and mechanosensitive transcription factor MRTF‐a, and found a reduction in the expression of these genes in the TRPV4 KO mice pre‐ and post‐cardiac injury. Altogether, our findings suggest that the absence of TRPV4 improves the cardiac function and remodeling following myocardial injury, and could lead to a novel therapeutic target for cardiac fibrosis.
In vitro regulation and cultivation of salmonid lymphocytes

approved: Stephen L. Kaattari Redacted for Privacy The foundation of the research compilation presented here began with the derivation of an improved method for obtaining optimal in vitro mitogenic responses in salmonid lymphocyte cultures by utilizing autologous or homologous plasma as the primary serum supplement. It was observed that lymphocytes which were previously unresponsive to mitogenic challenge in vitro, when cultured in fetal bovine serum, responded well when cultured in the presence of homologous plasma. Salmonid plasma sources not only repeatedly enhanced the mitogen-specific proliferation of the lymphocyte cultures, but enhanced the antibody response as well. A prolonged kinetic response further supported the contention that former conditions of salmonid lymphocyte culture, employing only fetal bovine serum, not only fail to provide the optimal conditions for cell growth, but in many cases the essential conditions. Enhancement of the mitogenic response was observed for three distinct species, using a common plasma source, suggesting utilization of plasma as an alternate serum supplement has broad applications and may be adapted to many fish systems. With this improved culture system, examination of the regulation of lymphocytes, specifically B cells, was undertaken. Evidence for the existence of a natural regulatory cell population located in the anterior kidney is presented. Addition of anterior kidney cells to either autologous peripheral blood or spleen cell cultures resulted in significant suppression of the mitogen response. The degree of suppressor activity appears to be correlated with the anterior kidney lymphocyte's ability to respond to mitogenic stimulus. It is demonstrated that a decrease in the anterior kidney mitogen response correlates significantly with an increase in the suppressor activity observed upon coculture of these same cells with peripheral blood lymphocytes. Interestingly, while addition of anterior kidney cells to spleen plaque forming cell cultures also resulted in suppression, anterior kidney cells had either no effect or enhanced the antibody response of the peripheral blood lymphocyte cultures. It is postulated that the mediator of this anterior kidney activity is a suppressor cell population which may possess an important immunoregulatory function. In Vitro Regulation and Cultivation of Salmonid Lymphocytes
The relevance of visual prosody for studies in language and speech-language pathology

I support Peppé's (2009) claim that prosody should be put on the research agenda of those working on aspects of language and speech-language pathology. But while her lead article mainly focuses on auditory forms of prosody, such as intonation, rhythm and voice quality, I argue that visual forms of prosody, in particular facial expressions, also need to be explored in this domain. Indeed, both variations in the voice and face are part of a speaker's expressive style, and are picked up as communicatively relevant cues by addressees. At the same time, there is preliminary evidence from studies of people with autism to suggest that they may have problems both with the production and comprehension of visual forms of prosody, and have difficulties to integrate input from different modalities. And finally, I propose a game-based paradigm which is potentially useful for the diagnosis and therapy of people who experience problems with the use of facial expressions in their social and linguistic interactions.
Effect of roselle (Hibiscus sabdariffa) flowers water extract on some egg properties of Japanese quail.

This study was conducted at the Agricultural Research and Experimentation Station, Agriculture Faculty, Al-Muthanna University, from 22/7/2015 to 22/11/2015, 256 quail female were used, six weeks age, randomly distributed to four treatments, 64 birds per treatment, four replicates each treatment, 16 birds per replicate, the water extract of the Roselle flowers was added to drinking water at a rate of 25, 50, 75 ml/liter of water for the T1, T2 and T3 respectively, leaving T4 (control) without addition, the traits studied were egg production percentage, egg mass, eggs weight, yolk weight, albumin weight, Shell with membrane weight, shell thickness, yolk diameter, yolk High, yolk index, albumin high and Haugh Unit. The results indicate that the Roselle flowers water extract had a significant effect (P=0.05) on the improvement of studied traits of egg production, egg production, egg weight, egg mass, egg quality (Haugh Unit, saffron and shell thickness) compare with the control treatment.