Miracle-dz/UniFAR-FTUs huggingface dataset:
Tratamiento de rizados en la estimación de la densidad espectral de potencia de la señal de ritmo cardiaco

RESUMEN El analisis de la Variabilidad de la Frecuencia cardiaca (VFC) esta basado en el estudio de los cambios detectados en cada ciclo cardiaco. Estos cambios son estudiados a partir de la senal de ritmo cardiaco y se compone de las medidas adquiridas del tiempo entre las ondas R de la senal electrocardiografica (ECG). El analisis de la senal de ritmo cardiaco esta basado en dos tipos de metodos: calculos estadisticos (dominio del tiempo) y estimacion de la densidad espectral de potencia (Dominio de la frecuencia). La Densidad Espectral de Potencia (PSD) de la senal de ritmo cardiaco puede realizarse a traves de metodos aplicados a senales con un tiempo de muestreo irregular. Para este caso, la literatura ha registrado el uso del metodo de Lomb. El principal objetivo de este trabajo es la presentacion de los resultados obtenidos de la implementacion de la tecnica basada en el promediado de espectros para realizar un tratamiento de la PSD estimada a partir de la senal de ritmo cardiaco. El procedimiento esta basado en tomar senales de ritmo cardiaco adquiridas de senales electrocardiograficas con ritmo sinusal normal de la base de datos “Physionet”. Los resultados obtenidos permitieron ilustrar una atenuacion del risado de la PSD estimada. PALABRAS CLAVES: Desidad Espectral de Potencia, Tiempos RR, muestreo irregular. Ripple treatment in power spectral density from rhythm cardiac signal ABSTRACT The analysis of heart rate variability (HRV) is based on the study of changes detected in each cardiac cycle. These changes have been studied from the cardiac rhythm signal and it is composed of data acquired from the time measured between the R waves of electrocardiographic signal. The cardiac rhythm signal analysis is based on two kinds of methods: statistical calculation (time domain) and the power spectrum density estimation (frequency domain). Power spectrum density (PSD) estimation from cardiac rhythm signal, can be done through math methods for signals with non-regular sampling time. For this case, in the literature has been registered the use of Lomb method. The main goal of this paper is the presentation of results obtained from the implementation of a technical based on spectrum averaging oriented to ripple decrease of the PSD estimation in cardiac signal rhythm. The final procedure is based on the application of the same technique taking cardiac rhythm signals acquired from normal sinus rhythm database “Physionet”. The results obtained from these experiments showed a decrease of ripple in the PSD and variation of parameters in the frequency domain. KEYWORDS: Power Spectral Density, RR time, non-regular sampling Forma de citar: GONZALEZ, Javier, FRANCISCO, Edwin y MARINO, Ivan. Tratamiento de Rizados en la Estimacion de la Densidad Espectral de Potencia de la Senal de Ritmo Cardiaco. Rev.UIS. Ingenierias, 2013, vol.12, n.2, p.p 17-27.
Les médias de masse sont-ils responsables des suicides en grappes ?

Les medias de masse sont regulierement mis en cause lorsque survient une serie de suicides dans la population, dans les jours ou les semaines suivant le traitement mediatique du recit d’un cas de suicide. L’objectif de cet article n’est pas de demontrer ou de refuter que les medias sont la cause de ces series de suicide. Cet article presente une synthese des resultats des recherches sur le lien entre les medias de masse et les suicides en grappes. L’article examine les hypotheses courantes avancees dans la litterature eu egard a ce lien et discute de la methode empirique sur laquelle s’appuient les chercheurs pour etudier la relation entre les medias de masse et le suicide. Fondees sur la comprehension limitee que nous avons actuellement du phenomene, des pistes de solutions se situant a la fois au plan theorique et au plan methodologique sont suggerees pour la recherche en ce domaine.
Effects and regulatory mechanism of tissue engineering biomaterial scaffold on host innate immune response

Tissue engineering biomaterial scaffold, as a tool, has been used clinically for many years to promote wound healing and tissue repair. Biomaterial implantation may unavoidably induce host response, and excessive host response can impact the success rate of implantation, and directly affect the outcome of the healing process. Therefore, reasonable modulation of host response during tissue healing process is crucial. The host response triggered by biomaterials is mainly regulated by the immune system, especially the innate immunity. Meanwhile, the innate immunity is an integral key factor in tissue repair and regeneration. In recent years, the impact of biomaterials on immune function is attracting more and more attention. Lots of studies have shown that tissue engineering biomaterials have been involved in innate immune regulation, and the material ingredients, surface chemistry, physicochemical properties, as well as the degradation products exert marked influence on the function of innate immune cells with different extents. This review is to brief our understanding concerning how the characteristics of tissue engineering scaffolds affect the innate immune system and the potential effect of innate immunity on tissue repair, which might be of great significance to seek a novel way for designing advanced immunomodulatory tissue engineering scaffolds. DOI: 10.11855/j.issn. 0577-7402.2018. 08.14
Title:Dose-Adjusted EPOCH Plus Rituximab (DA-EPOCH-R) in Untreated Patients with Poor Risk Large B-Cell Lymphoma. A Phase 2 Study Conducted by the Spanish PETHEMA Group.

Abstract 2701 Poster Board II-677 Background. Since the development of CHOP chemotherapy, many efforts have been made to improve first line treatment in aggressive lymphomas, mainly in poor prognosis cases. To assess the efficacy and safety of an infusional DA-EPOCH plus Rituximab (DA-EPOCH-R) regimen in poor prognosis large B-cell lymphomas, the Spanish PETHEMA group conducted a phase 2 study in patients with a higher than 1 aaIPI in this setting. Methods: Eligibility criteria included histologically documented DLBCL, grade 3b follicular lymphoma or primary mediastinal B-cell lymphoma, IPI higher than 2 or aaIPI higher than 1 (or equal to 1 plus bulky disease). No restriction was made based on ECOG performance status when they could understand and sign the informed consent. Radiation therapy as consolidation was permitted on bulky masses detected at diagnosis. Results: Herein, 71 patients were evaluated for safety and outcome: 32 were male and 39 female. Median age was 60 years (range: 21-77). DLBCL was diagnosed in 57 (80%), PMBCL in 6 (9%), and grade 3b follicular lymphoma 8 (11%). Eighty nine percent had advanced (III-IV) CS, and 58% presented B symptoms. Bulky disease (3 10 cm maximum diameter) was present in 18%. ECOG was higher than 2 in 13 patients (18%). b-2-microglobulin was elevated in 62%, and LDH in 90% of patients. AaIPI was: 1 in 7 patients (10%), 2 in 36 (51%), and 3 in 28 (39%). Four hundred and fifteen cycles were given. A grade 3-4 mucositis occurred in 9 occasions, and neutropenic fever or infections in 66 cycles (16%). Fifty nine patients (83%) achieved a CR or CRu, 6 (8%) a PR and 4 (6%) an inadequate response, there were 2 early deaths: a toxic one, due to septic shock, and one due to non-related cause (traumatism). Twenty six percent of patients who achieved a CR relapsed. Twenty one patients (30%) died so far: 76% due to progressive disease, one patient who had undergone an ASCT after relapse died from secondary MDS. With a median follow-up of 40 months the event-free survival and overall survival is 60% and 61% respectively at 5 years. Disease-free survival is 72% at 5 years for patients who achieved a CR or CRu. No statistically significant difference in overall survival were seen according to aaIPI risk factors. Conclusion: DA-EPOCH-R is an immunochemotherapy regimen with a clinically significant activity and a very acceptable toxicity profile in patients with poor prognosis aggressive B-cell lymphomas and could somehow overcome IPI risk factors. Disclosures: No relevant conflicts of interest to declare.
BOOTStrep Annotation Scheme: Encoding Information for Text Mining

Annotation of information in corpora is an important aspect of text mining. It bridges between the information hidden in natural language texts and the semantic search queries for the information desired by users. Due to the complex nature of the information needed for text mining, it is essential to design comprehensive annotation schemes to encode and organise the unstructured information contained in text into certain structured forms that can be processed by computers. In the EU BOOTStrep Project, which aims to pull together existing biological databases and various terminological repositories and implement a text analysis system to populate a BioLexicon and a Bio-Ontology to support text mining, an annotation scheme has been under construction for encoding multilayer information pertaining to text mining applications. In particular, it is aimed at supporting the interoperability among a set of text annotator tools. In practice, this annotation scheme is built into a type system of a software architecture, named the Unstructured Information Management System (UIMA), which provides a software architecture for the integration and interoperation of NLP annotation tools. Although this scheme is targeted at the biological domain and hence contains some biology-specific semantic elements, the major part of the annotation scheme covers generic language annotation, such as part-of-speech, syntactic parse, co-reference resolution, etc. Therefore, our scheme can easily be ported to other domains or generic language analysis tasks. Coupled with UIMA, this scheme provides a practical means of capturing information from texts for various purposes, such as text mining, NLP, corpus linguistics, etc.
La persistencia del mito y de lo imaginario en la cultura contemporánea

Este trabajo pretende mostrar la trascendencia filosofica y las diferentes expresiones sociologicas que adopta lo imaginario en la cultura contemporanea. Primero, comienza con el examen de la naturaleza antropologica profunda de lo imaginario, revelando la persistencia de un componente imaginario, propiamente no-racional, devaluado y soterrado por el racionalismo dominante a lo largo de la cultura occidental. Luego, partiendo de la conflictiva relacion existente entre modernidad e imaginario, revela las dos manifestaciones fundamentales de lo imaginario en la epoca moderna: el progreso cientifico tecnologico y el campo de las identidades socio-politicas. Finalmente, descubre como lo imaginario sigue incluso operando en diferentes espacios cotidianos propios de la cultura de masas.
The effects of graph layout

Information visualisation systems which generate diagrams representing discrete relational information must consider potential users if they are to be effective. Many algorithms which render an abstract graph structure as a diagram are valued for their conformance to aesthetic criteria, or for computational efficiency. They are not usually judged on their ability to produce diagrams that maximise human performance. The paper presents the results of experiments investigating the relative worth (from an HCI point of view) of graph drawing aesthetics and algorithms using a single graph. The results indicate that while some individual aesthetics affect human performance, it is difficult to say that one algorithm is 'better' than another from a relational understanding point of view.
你能想象出來嗎？ : Using mnemonics with distributed practice and practice testing to facilitate learning of Chinese characters

This study investigates student experiences of the experimental memory technique called the People Placing Method, which is a collection of adapted learning techniques. This study looks at the students’ experiences of using this experimental method, using an individual pscychological theoretical framework. The People Placing Method was taught to a group of Swedish foreign language students during spring 2013. Data was collected using two surveys, a diagnostic test and a series of interviews. The analysis showed that few students actually use the whole method after training and many students view the method as having a high initial threshold. Users, however, rated the technique as effective and users also gained a non-significant higher mean value on the diagnostic test. The study showed that students work in an adaptive way when learning new techniques, and that they use selected parts of the People Placing Method and sometimes combining these with digital support.
Danny Miller : de la stratégie aux entreprises familiales

Danny Miller, vous avez ete classe dans une publication recente de Journal of Management comme le cinquieme chercheur en gestion le plus cite dans le monde: c'est dire que votre production scientifique est particulierement riche. De votre these a votre ouvrage Managing for the Long Run en passant par Le Paradoxe d'Icare pouvez-vous nous retracer l'itineraire intellectuel qui vous a amene de la strategie, ou vous etes un des chefs de file de l'ecole " configurationniste ", a l'entrepreneuriat et aux entreprises familiales ?
Acquisition of semantic patterns for information extraction from corpora

A knowledge acquisition tool to extract semantic patterns for a memory-based information retrieval system is presented. The major goal of this tool is to facilitate the construction of a large knowledge base of semantic patterns. The system acquires semantic patterns from texts with a small amount of user interaction. It acquires new phrasal patterns from the input text, maps each element of the pattern to a meaning frame, generalizes the acquired pattern, and merges it into the current knowledge base. Interaction with the user is introduced at some decision points, where the ambiguity cannot be resolved automatically without other pieces of predefined knowledge. The acquisition process is described in detail, and a preliminary experimental result is discussed. <<ETX>>
Etelcalcetide: A New Intravenous Calcimimetic for the Treatment of Secondary Hyperparathyroidism in Haemodialysis Patients

Etelcalcetide hydrochloride (also known as AMG 416) is a new, second generation, long-acting calcimimetic agent that is administered intravenously. In November 2016 it received its first approval in the UE for the treatment of secondary hyperparathyroidism (SHPT) in adult haemodialysis patients. This article summarizes the results of pre-clinical and clinical studies which demonstrated that Etelcalcetide decreases effectively PTH levels. Although questions about this new compound remain open, and further studies are required to assess clinical hard outcomes as well as long term efficacy and safety, Etelcalcetide represents a new therapeutic option for the challenging treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD).
Point Clouds as an Efficient Multiscale Layered Spatial Representation

3D point clouds describe urban shape at different scales, precisions and resolutions depending on the underlying sensors and acquisition methodology. These factors influence the quality of the data, as well as its representativity. In this paper, we propose a multi-scale workflow to obtain a better description of the captured environment through a multi-scale representative point cloud, presenting an unlimited depth and multisensory data fusion. Our method is shown over a "smart point cloud" data structure and based on data fusion principles retaining higher description and precision on overlapping areas. The concept is illustrated through a use case on the castle of Jehay (Belgium), where aerial LiDAR data, terrestrial laser scanner point cloud and photogrammetry-based reconstruction are combined to obtain a multi-scale data structure.
Amélioration de la participation des patients au dépistage organisé du cancer colorectal par l'implication des médecins généralistes

Contexte : Actuellement en France, le taux de participation au depistage organise du cancer colorectal (CCR) reste nettement inferieur aux recommandations europeennes et ce, malgre l’implication des medecins generalistes.Objectifs : L’objectif general de ce travail de these etait d’evaluer les pratiques des medecins generalistes en matiere de depistage organise du CCR, de comprendre les freins au depistage et d’evaluer les strategies permettant d’ameliorer la participation des patients a ce depistage.Methode : Nos travaux se sont appuyes sur les donnees du programme de depistage organise dans le Val-de-Marne. Nous avons reconstitue une cohorte historique de 157 979 patients suivis par 961 medecins generalistes, mene une recherche-action aupres de 21 medecins volontaires et realise un essai controle randomise en grappes incluant 144 medecins et 20 778 patients.Resultats : Une faible part de la variabilite de la probabilite de participation etait attribuable a l’heterogeneite entre medecins (coefficient de correlation intra-classe, 5,5%). La participation au depistage etait moindre chez les hommes (odds ratio [OR], 0,79 ; IC 95%, 0,78–0,91), les jeunes (50–54 ans, OR, 0.61 ; IC 95%, 0.58–0.63 ; 55–59 ans, OR, 0.76 ; IC 95%, 0.73–0.80) ou les residents des zones les plus defavorisees (OR, 0.82 ; IC 95%, 0.77–0.87). Nous avons identifies 7 exigences essentielles pour l'activite de depistage organise du cancer colorectal par le medecin generaliste : Etre proactif, Etre un partenaire, Prendre en compte l’entourage, Se positionner comme expert du probleme, Gerer le temps de maniere efficiente, Expliquer la realisation du test et Aider la realisation du test. Pour chacune, nous avons pu identifier des techniques utilisables en situation de pratique clinique.Les rappels systematiques adresses par voie postale aux medecins generalistes comportant la liste mise a jour de leurs patients eligibles au depistage n'ont pas augmente de maniere significative la participation des patients au depistage apres prise en compte de l’effet grappe (analyse multiniveau). Conclusions : Des actions ciblees vers les patients les plus jeunes, les hommes et les residents des zones geographiques les plus defavorisees devraient etre encouragees afin de reduire les disparites observees et ameliorer l’efficacite globale du programme de depistage. Des actions sur l'ensemble des medecins generalistes doivent etre envisagees : mettre l'approche centree sur le patient et la pratique reflexive au cœur du projet de formation initiale et continue, et proposer des recommandations de pratique basees sur les donnees issues de la pratique.
Design and Implementation of a Relaxed Haar Discreet Wavelet Transform Hardware module for Multimedia Compression

Abstract: Still Images and video clips are common formats for storing and sharing information in different fields. Information content in such multimedia formats is huge and requires compression. Compression is done to reduce redundant information content while maintaining good perceptual video or Image quality for Human Visual Systems (HVS) and involves signal transformation together with other operations. While MPEG-X and H.26X deploy DCT (Discreet Cosine Transform), Discreet Wavelet Transforms (DWTs) are common in different multimedia CODECs such as MJPEG2000, MJPEG-XR and MJPEG-LS. DWT like all other transformations requires intensive computation and consume more power. To mitigate the trade-off between computation duration, bulkiness of subsystems and power consumption, Software-Hardware co-design approach is used. In this approach, Hardware modules called hardware accelerators are reserved for intensive functions and are called by the main program as a subroutine, thus a good flexible design approach is required for such hardware circuit modules. In this paper, we revisit the fundamentals of Haar DWT. We exploit its flexibility and simplicity to design a relaxed Hardware module that can be used to process a 16x16 spatial micro block from an Image or a video frame without multiplication because multiplications takes longer and hence more power consumption. The Module is Implemented on FPGA Keywords– Discreet Wavelet Transform, Multimedia Compression, Hardware Realization, FPGA
HRVC is the commonest rhinovirus group detected in children admitted to a paediatric intensive care unit with respiratory illnesses

Introduction: Respiratory viruses account for a significant proportion of acute admissions to the paediatric intensive care unit (PICU). Acute respiratory illnesses (ARI) represent 10-15% of all admissions to PICU. Recent studies have shown that human rhinovirus (HRV) was the most frequent virus detected in severe cases of ARI admitted to a PICU. There has been no study to date examining the prevalence of HRV groups (including the newly discovered HRVC group) in children admitted to a PICU. Aim: The aim of this study was to determine the prevalence of different HRV groups in children with respiratory illnesses admitted to a tertiary PICU. Methods: Nasopharyngeal aspirates (NPA) and clinical information were obtained from children admitted with respiratory illnesses to PICU between March 2009 and July 2011. RNA was extracted from NPA, and reversed transcribed. From cDNA, a 2-step PCR of the HRV 5′NCR was used for HRV detection, and sequencing for typing. Results: NPA from 229 children admitted to PICU were analysed. HRV was the commonest virus, being present in 93 (40.6%) samples examined, followed by respiratory syncytial virus (RSV) which was identified in 50 (21.8%) samples. Of the 77 NPA available for HRV typing, HRVC was found to be the commonest HRV group detected, representing 42 (54.5%) of the samples identified. HRVA group was found in 32 (41.5%) and HRVB in 3 (4%) of the samples analysed. Conclusions: This study demonstrated that HRV is the commonest virus identified in children admitted to a tertiary PICU with a respiratory illness. In addition, HRVC was the commonest HRV group detected across all respiratory illnesses.
Cateterización venosa central guiada por ecografía: estudio randomizado controlado

1. Profesor Adjunto Cátedra de Anestesiología, Facultad de Medicina, UDELAR. Coordinadora de Investigación, Unidad Docente Asistencial: Centro Nacional Hepato-BilioPancreático. 2. Postgrado Medicina Intensiva, Cátedra de Medicina Intensiva, Facultad de Medicina, UDELAR. Hospital Central de las Fuerzas Armadas (HCFFAA). 3. Médico Coordinador Centro de Cuidados Especiales (CCE) del HCFFAA. Unidad Docente Asistencial: Centro Nacional Hepato-Bilio-Pancreático. Correspondencia: Dra. Karina Rando. Correo electrónico: Karina.rando@gmail.com y krando@fing.edu. uy
Excavations at Ardnadam, Cowal, Argyll, 1964-1982

Summary This multi-period site in Ardnadam Glen had been occupied by man intermittently through five millennia. It is not possible to estimate the length of each of the eight periods described owing to the scarcity of datable finds although the Early Neolithic and the Iron Age occupations are fixed approximately by radio carbondating. The Early Neolithic is represented by pottery, flint tools, hearths, post holes and banks of stone; the later Neolithic, by the remains of a round house and pottery. An Iron Age occupation is suggested by the remains of two round houses, followed by an early Christian settlement with an enclosure, a possible house, a possible ‘cell’, graves, cross-marked stones and a chapel. The Medieval period is represented by remains of another house, datable pottery, paving, evidence of iron-working and charcoalburning. Later activity is incidental, but the area was probably usedas a burial ground until late Medieval times. The entire site stands on an alluvial fan and suffered at interv.