Miracle-dz/UniFAR-FTUs huggingface dataset:
THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

Aim: to investigate the relationship among pull up and lat pull exercises and different anthropometric dimensions in trained athletes. Methods: twenty-five males were evaluated for maximum number of pull ups, one-repetition maximum lat pull (1RM Lat Pull), lat pull repetitions at 80% 1RM (Lat Pull at 80% 1RM), lat pull repetitions at a load equivalent to body mass (Lat Pull at BM-load), and different anthropometric variables. Furthermore, the subjects were divided in higher (HPG, n = 12) and lower pull up performance (LPG, n = 13) to compare the differences in the variables analyzed between both levels. Results: pull ups were significantly correlated with Lat Pull at BM-load (r = .62, P < .01) but neither with 1RM Lat Pull (r = .09) nor with Lat Pull at 80% 1RM (r = -.15). Pull ups showed a significant (P < .05) negative relationship with body mass (BM, r = -.55), lean body mass (LBM, r = -.51), and fat mass (FM, r = -.52), while BM and LBM were significantly correlated with 1RM Lat Pull (r = .55, P < .05). HPG showed significantly (P < .05) lower BM (0/3/97%), FM (1/3/97%) and LBM (1/4/95%) than LPG. Furthermore, HPG attained significantly (P < .05 – .001) greater performance in Lat Pull at BM-load (100/0/0%) and 1RM Lat Pull•BM (96/3/2%) than LPG. Conclusion: these findings suggest that pull up and lat pull exercises have common elements. Moreover, the anthropometric dimensions seem to influence differently on both exercises, depending on the strength indicator evaluated.
Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways

Melanogenesis is the biological process which the skin pigment melanin is synthesized to protect the skin against ultraviolet irradiation and other external stresses. Abnormal biology of melanocytes is closely associated with depigmented skin disorders such as vitiligo. In this study, we examined the effects of maclurin on melanogenesis and cytoprotection. Maclurin enhanced cellular tyrosinase activity as well as cellular melanin levels. We found that maclurin treatment increased the expression of microphthalmia-associated transcription factor (MITF), tyrosinase-related protein- (TRP-) 1, TRP-2, and tyrosinase. Mechanistically, maclurin promoted melanogenesis through cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein-dependent upregulation of MITF. CREB activation was found to be mediated by p38 mitogen-activated protein kinase (MAPK) or cAMP-protein kinase A (PKA) signaling. In addition, maclurin-induced CREB phosphorylation was mediated through the activation of both the cAMP/PKA and the p38 MAPK signaling pathways. Maclurin-induced suppression of p44/42 MAPK activation also contributed to its melanogenic activity. Furthermore, maclurin showed protective effects against H2O2 treatment and UVB irradiation in human melanocytes. These findings indicate that the melanogenic effects of maclurin depend on increased MITF gene expression, which is mediated by the activation of both p38 MAPK/CREB and cAMP/PKA/CREB signaling. Our results thus suggest that maclurin could be useful as a protective agent against hypopigmented skin disorders.
Non-uniformly sampled sequential data processing

NON-UNIFORMLY SAMPLED SEQUENTIAL DATA PROCESSING Safa Onur Şahin M.S. in Electrical and Electronics Engineering Advisor: Süleyman Serdar Kozat September 2019 We study classification and regression for variable length sequential data, which is either non-uniformly sampled or contains missing samples. In most sequential data processing studies, one considers data sequence is uniformly sampled and complete, i.e., does not contain missing input values. However, non-uniformly sampled sequences and the missing data problem appear in a wide range of fields such as medical imaging and financial data. To resolve these problems, certain preprocessing techniques, statistical assumptions and imputation methods are usually employed. However, these approaches suffer since the statistical assumptions do not hold in general and the imputation of artificially generated and unrelated inputs deteriorate the model. To mitigate these problems, in chapter 2, we introduce a novel Long Short-Term Memory (LSTM) architecture. In particular, we extend the classical LSTM network with additional time gates, which incorporate the time information as a nonlinear scaling factor on the conventional gates. We also provide forward pass and backward pass update equations for the proposed LSTM architecture. We show that our approach is superior to the classical LSTM architecture, when there is correlation between time samples. In chapter 3, we investigate regression for variable length sequential data containing missing samples and introduce a novel tree architecture based on the Long Short-Term Memory (LSTM) networks. In our architecture, we employ a variable number of LSTM networks, which use only the existing inputs in the sequence, in a tree-like architecture without any statistical assumptions or imputations on the missing data. In particular, we incorporate the missingness information by selecting a subset of these LSTM networks based on presence-pattern of a certain number of previous inputs.
Evaluation of Lactobacillus spp. isolated from locally consumed probiotic food in Nsukka, Enugu State, Nigeria for antimicrobial activity utilizing agar well diffusion and pH tolerance tests

Antimicrobial activity against entero-pathogens and tolerance to acid stress are crucial characters of probiotic bacteria. Lactobacillus spp. isolates were phenotypically characterized using colony observation, catalase test and Gram stain reaction. The pH (1.5, 2.5 and 3.5) tolerance of each isolate was evaluated at 0 and 4 h. The antibacterial activities of the isolates were tested against pathogenic strains of Bacillus spp. , Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium and Staphylococcus aureus. Among the isolates screened, 20 were Gram positive and catalase negative. In an agar well diffusion, isolate O4 resulted in the highest inhibition zone diameter, 13 mm against P. aeruginosa while isolates OK4, UK1, P2, P3 and P4 did not produce any inhibition zones against any of the pathogens tested. Isolate Y1 showed the broadest inhibitory activity against the pathogens tested inhibiting all the pathogens tested except S. typhimurium. The pH tolerability studies showed that the isolates proliferated more at lower acidic pH: 1.5 > 2.5 > 3.5. Food products containing Ogiri, Ukpaka, Okpeye, Akamu and Yoghurt provides useful sources of probiotic bacteria. Key words: Antimicrobial activity, Lactobacillus spp, pH tolerance, entero-pathogens.
Application Of Design Aspects In Online Learning Content

There are many online learning materials found in universities in Indonesia that use face-to-face materials. Teaching materials used in the material in the class are transferred to the content of online learning material. There are many visual elements in learning material that only decorative function and have not been optimal in knowledge construction. This study will design an experiment with a focus on teaching material for lecture material that is dominant in the cognitive domain. Case studies on theoretical lecture material from social science. The comparison experiment will use two groups of students selected randomly. One group of students will be made into a control group and another group of students will be made into the experimental group. The effectiveness of the results will be measured by learning evaluation in the form of retention tests and transfer tests. This evaluation is related to the learning outcomes of the cognitive domain. This research is in the ongoing research phase. This paper is expected to trigger further discussion both in the methodology and content of the experimental features. The results of this study are expected to be used as a reference for lecturers in designing online teaching materials. Keywords Online learning material, design aspect, user experience
On the Efficacy of Character Education for Cultivating Virtue

This dissertation serves to support deliberate attempts to cultivate moral character. Character education faces criticism, some of which are inherited from its grounding in virtue theory. The aim of this dissertation is to confront these particular critiques and show that they can be answered in an effort to vindicate the prospects of character education. When philosophers question whether character traits are stable and robust in the way that virtue theory posits them to be, a similar problem holds for character education: is there any point to character education if character does not exist in the way we traditionally think about it? I appropriate Christian Miller’s Mixed Traits framework to show that character education can handle standard situationist challenges that maintain that our environments are better predictors of our behaviors than our characters. Another problem concerns the possibility of developing the kinds of character traits that character education dictates. I defend the possibility, motivated in part by the work of Michael Slote, Nancy Snow, and others. I argue that active cultivation is not only the most promising method for character development, it is also necessary for becoming virtuous. I defend a two-tier approach to character and virtue acquisition that is skill-based, and involves teaching and fostering skills of self-awareness, perception, and responsiveness. My account faces opposition on grounds that various influences can interfere in the process of cultivation. Eric Schwitzgebel and Jennifer Saul raise skepticism regarding the extent to which we can rely on our mental faculties, and Heather Battaly challenges the role environment can play in virtue development. I recognize the call for strategies to overcome both internal and external influences and respond by drawing on contemporary empirical research. Teaching skills of self-awareness, perception, and responsiveness, and offering opportunities to practice these skills will enable students to become virtuous. This project is grounded in and motivated by philosophical, psychological, and educational research. It proposes a realistic and empirically supported approach to character development. I am optimistic that a skill-based approach will enable students to become virtuous, and hopeful that it will be implemented in curriculum in the future.
A review of demodulation techniques for multifrequency atomic force microscopy

This article compares the performance of traditional and recently proposed demodulators for multifrequency atomic force microscopy. The compared methods include the lock-in amplifier, coherent demodulator, Kalman filter, Lyapunov filter, and direct-design demodulator. Each method is implemented on a field-programmable gate array (FPGA) with a sampling rate of 1.5 MHz. The metrics for comparison include the sensitivity to other frequency components and the magnitude of demodulation artifacts for a range of demodulator bandwidths. Performance differences are demonstrated through higher harmonic atomic force microscopy imaging.
Resultados da implementação de um programa de reabilitação em utentes submetidos a artroplastia total do joelho

Theoretical framework: Knee osteoarthritis is a common disease in the elderly. Chronic pain and disability make sometimes required surgical treatment through arthroplasty. Pre and post-total knee arthroplasty rehabilitation may improve functionality and the health status of patients for better adaptation to daily activities. Aim: Evaluate results of a rehabilitation nursing program conducted in patients with osteoarthrosis undergoing total knee arthroplasty. Methodology: Quantitative research was used in a quasi-experimental nonrandomized study, with evaluation before and after intervention. Results: The study sample (71.38 ± 5.93 years) consisted of 26 (52%) men subjects. Before surgery walk independently was prevalent in 70% of patients. Postoperatively knee range of motion was correlated with the preoperatively values, for flexion and extension. Patients were discharged making, on average, 91 ° flexion. We observed significant improvements in static and dynamic balance by Tinetti Index. At the time of discharge we obtained an average 91.3 points in the Barthel Index. Conclusion: The results suggest that the rehabilitation program performed during hospitalization improved the functional independence of patients undergoing total knee arthroplasty.
POR_A_214412 67..76

Joe Alexander Jr* Roger A Edwards* Luigi Manca 3 Roberto Grugni 3 Gianluca Bonfanti Birol Emir Ed Whalen Steve Watt Marina Brodsky Bruce Parsons 6 1Global Medical Affairs, Pfizer Inc, New York, NY 10017, USA; 2Health Services Consulting Corporation, Boxborough, MA 01719, USA; 3Fair Dynamics Consulting, SRL, Milan, Italy; 4Global Statistics, Pfizer Inc, New York, NY 10017, USA; 5Global Medical Affairs, Pfizer Inc, Groton, CT 06340, USA; 6Global Medical Product Evaluation, Pfizer Inc, New York, NY 10017, USA
Acaricidal activity of different plant extracts against stored grain mites Rhizoglyphus tritici (Acaridae: Acari)

Stored grain mites are most harmful pests of stored grains and other stored products. Mites are microscopic organisms. They cause damage in many ways particularly by infesting grains and damage its quality. These mites are also a factor for lowering the germination rate because they feed on embryo of grain seeds and make it unfit for sowing. Many acaricides are being used worldwide against the infestation of stored grain mites. But, many drawbacks have been identifiedof these chemicals in last few decades. So, there is a need to develop such control techniques which would be more effective and environment friendly. In this scenario, the use of botanicals like leaf extracts against these certain pest species is a new trend in Pakistan which is the demand of current time. The main purpose of this study wasto check the efficacy of different leaf extracts Neem (Azadirachta indica), Mosambi peel (Citrus cinensis), Gardenia (Gardenia carinata) and Clove (Syzygium aromaticum) against stored grain mites. The mortality of mites was recorded after 24, 48, 72 and 96 h. After 24 and 48 h mortality trend of plant extracts was G. carinata>A. indica>S. aromaticum>C. cinensis. After 72 and 96 h G. carinata and S. aromaticum contributed equal mortality whereas A. indica showed less mortality but minium mortality was observed by C. cinensis. It is concluded that G. and Clove can be used as an important part of future IPM programs against stored grain mite pests.
Statistical Issues in Small and Large Sample: Need of Optimum Upper Bound for the Sample Size

As fewer samples are meaningless and lead to fallacious conclusions, researchers are used to calculate minimum sample size before the conduct of any study. Although the larger samples can yield more accurate results, an extent for maximum sample size is not fixed. Though large samples are able to give précised and accurate estimates, the studies that collect more samples than the minimum required, may lead to fallacious conclusions. Generally, the test statistics are increasing functions of sample size and limit of the p value (as ‘n’ tents to infinity) results the statistical significance. The current paper investigated the pattern of changes in the estimates and testing results for varying sample sizes. The assessment of this type of patterns in the data and an extended study on this topic will help to find an interval for the sample size. Study concluded with a finding that larger sample does not make differences on the values of descriptive statistics, but has significant impact on the values of inferential statistics and therefore an upper bound for the sample size needs to be fixed. Hence this article gives relevant information about the need of finding adequate sample size interval (n1, n2) within which valid statistical conclusions can be derived, that assures significance of real difference.
Scalar and Vectorial mu-calculus with Atoms

We study an extension of modal $\mu$-calculus to sets with atoms and we study its basic properties. Model checking is decidable on orbit-finite structures, and a correspondence to parity games holds. On the other hand, satisfiability becomes undecidable. We also show expressive limitations of atom-enriched $\mu$-calculi, and explain how their expressive power depends on the structure of atoms used, and on the choice between basic or vectorial syntax.
F eb 2 01 4 Massless spectrum for hybrid CFTs

We describe a class of theories obtained by fibering a LandauGinburg orbifold over a compact Kähler base. While such theories are often described as phases of some GLSM, our description is independent of such an embedding. We provide a method for computing the massless spectrum. This note is based on the longer paper arXiv:1307.7063.
The Role of Past Experience with a Single Climate Physical Risk in Adaptation Response to Multiple Climate Physical Risks: A Multiple Case Study of Italian Companies

With the increasing occurrence and intensity of weather and climate extremes, adaptation to climate change has become an imperative for all the societal actors, including companies. Business adaptation behavior is influenced by specific internal and external conditions. Based on a multiple case study of Italian companies within the project Life IRIS (Improve Resilience of Industry Sector), the paper examines the interaction of multiple physical risk drivers and organizational factors that trigger a change in the adaptation behavior of companies to climate change, from a deferred behavior to a reactive one and, then, to a pre-emptive behavior over time. In particular, the study shows how past experience with a single climate event can trigger a comprehensive strategy to deal with multiple climate events. Implications for management practice and policymakers are discussed at the end of the paper.
Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome group B gene knockout mice

Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementary group B (CS-B) gene (csb) encodes the CSB protein (CSB) that is involved in base excision repair of a number of oxidatively induced lesions in genomic DNA in vivo. We hypothesized that CSB may also play a role in cellular repair of the helix-distorting tandem lesion (5'S)-8,5'-cyclo2'-deoxyadenosine (S-cdA). Among many DNA lesions, S-cdA is unique in that it represents a concomitant damage to both the sugar and base moieties of the same nucleoside. Because of the presence of the C8–C5' covalent bond, S-cdA is repaired by nucleotide excision repair unlike most of other oxidatively induced lesions in DNA, which are subject to base excision repair. To test our hypothesis, we isolated genomic DNA samples from brain, kidney and liver of wild type and csb knockout (csb) mice. Animals were not exposed to any exogenous oxidative stress before the experiment. DNA samples were analyzed by liquid chromatography/mass spectrometry with isotope-dilution. Statistically greater background levels of S-cdA were observed in all three organs of csb mice than in those of wild type mice. These results suggest in vivo accumulation of S-cdA in genomic DNA due to lack of its repair in csb mice. Thus, this study provides, for the first time, the evidence that CSB plays a role in nucleotide excision repair of the DNA helix-distorting tandem lesion S-cdA. Accumulation of unrepaired S-cdA in vivo may contribute to the pathology associated with CS.
Weber's Konzertstück op. 79, or Programming Piano Concertos in Early-nineteenth Century Concerts (The Birth of the Piano Concerto, Chapter 5)

A survey of nineteenth-century concert programmes would astound many people for various reasons. First, the length of each event is difficult to imagine for modern concertgoers. It was not unusual for a concert to last three or four hours. As the century progressed, the number of performed pieces per concert was reduced and concerts were shortened; this trend was already perceptible by the middle of the century (Schwab 1971: 15). However, nineteenthcentury concerts in general were still longer than most in the twenty-first century in Japan, where we are accustomed to events lasting from 7‒9 pm. Today, for example, most Japanese music admirers would be surprised at the length of events such as a concert programmed by Ludwig van Beethoven (1770‒1827) on 2 April 1800 that featured seven works, including a symphony of Wolfgang Amadeus Mozart (1756‒91) and one of Beethoven (the premiere of his first symphony). The constitution of a concert series at the Music Academy in Berne in 1803 shows that some restriction was necessary to stop concerts from becoming excessively long.
The role of multimodal navigation in endoscopic endonasal surgery for giant pituitary adenomas.

Background Giant pituitary adenoma (GPA) (diameter >40 mm) remains challenging to treat, and the radical resection rate is low. The intraoperative multimodal navigation is sometimes used in endoscopic endonasal surgery (EES). However, the effect of this technique on GPA surgical outcomes is not clear. This study aims to explore the surgical and clinical outcomes of the navigation used in EES for GPA. Methods A retrospective review of 60 consecutive patients with GPA who underwent EES was performed. The total resection rate, residual volume, clinical outcomes, and complications were compared. Factors associated with tumor gross total resection (GTR) were analyzed by multinomial logistic regression analysis. Results There were 31 patients in the standard group in which intraoperative multimodal navigation was not used, with a mean maximum tumor diameter of 5.21±1.24 cm; meanwhile, there were 29 patients in the navigation group, in which navigation was used, with a mean maximum tumor diameter of 5.32±1.18 cm. GTR was achieved in 10 patients (32.26%) in the standard group, which was significantly lower than that in the navigation group (18/29=62.07%). The residual volume was 7.93±10.78 cm3 in the standard group which was significantly greater than that in the navigation group (2.44±1.26 cm3, P=0.046). There was no signiﬁcant difference between the two groups in terms of cerebrospinal fluid (CSF) leak, new pituitary deficit, and postoperative diabetes insipidus (DI). The higher Knosp grade of tumor, lobulated configuration and lack of intraoperative multimodal navigation use were relative risk factors associated with the GTR. Conclusions The intraoperative multimode navigation appeared to be safe and effective when used in EES for GPA with higher GTR and lower residual tumor volume.
Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes

There is unexplained deficit in size and function of the exocrine pancreas in type 1 diabetes (T1D). We obtained pancreas from an individual with pre-T1D obtained at surgery and addressed the question, what is the relative inflammation in the exocrine and endocrine pancreas in pre-T1D in the absence of the potential confounding changes at autopsy or in brain dead organ donors. Pancreas was removed surgically from a 36 year woman for benign neuroendocrine tumors (NET). The patient had gestational diabetes at age 29 and has a 23 year old sister with T1D. Pre-operative fasting glucose of 109 mg/dl and HbA1C 5.8% revealed prediabetes with an anti-GAD 1,144 (5–250 U/ml) together with family history implying pre-T1D. There was patchy low grade immune infiltration in some, but not all, islets that met criteria for autoimmune insulitis. The exocrine pancreas showed more abundant inflammation with areas of chronic pancreatitis and acinar to ductal metaplasia, and with other areas of atrophy and fatty infiltration. In pre-T1D inflammation may be more prominent in the exocrine than the endocrine pancreas, calling into question the sequence of events and assumed islet centric basis of autoimmunity leading to T1D.