Miracle-dz/UniFAR-FTUs huggingface dataset:
Utility of the daily prospective National Institute of Mental Health Life‐Chart Method (NIMH‐LCM‐p) ratings in clinical trials of bipolar disorder

This study investigated the assets of the daily prospective National Institute of Mental Health Life‐Chart Method (NIMH‐LCM‐p or LCM‐p) for use in clinical trials in bipolar disorder. Fifty‐two outpatients, who met DSM‐III‐R criteria for bipolar disorder, were randomly assigned in a double‐blind design to an intended 1 year of treatment with lithium or carbamazepine, a crossover to the opposite drug in the second year, and then to a combination of both agents in the third year. For each patient, the LCM‐p was initiated upon admission and was continued on a daily basis. Overall therapeutic effect for each phase (intended year) was assessed by using the Clinical Global Impressions‐Bipolar Version (CGI‐BP) scale. Kruskal‐Wallis analysis of variance was used to examine the detailed course‐of‐illness variables derived from the LCM‐p (e.g., percentage of time ill, average severity of illness, episodes per year, and mood switches per year) in relation to the global assessments of treatment response (CGI‐BP). Most of the individual LCM‐p‐derived illness variables varied significantly (P < .05) as a function of global treatment response. Since global ratings of the degree of improvement can represent very different proportions of improvement in percentage of time ill, average severity of mania or depression, or frequency of manic and depressive episodes, the LCM‐p provides the basis for a comprehensive description of both the illness course and the response to treatment. The LCM‐p appears to have considerable utility in clinical trials of pharmacological and other interventions of bipolar disorder. It provides a detailed characterization of the severity, frequency, and duration of manic and depressive episodes, which facilitates the assessment of global improvement and allows for the quantification of separate components of the illness, which are or are not responsive to a given treatment. Depression and Anxiety 15:1–9, 2002. © 2002 Wiley‐Liss, Inc.
Methodology for performing RF reliability experiments on a generic test structure

This paper discusses a new technique developed for generating well defined RF large voltage swing signals for on wafer experiments. This technique can be employed for performing a broad range of different RF reliability experiments on one generic test structure. The frequency dependence of a gate-oxide wear out stress was investigated using this methodology for frequencies of up to 1 GHz.
A human T cell line with an abnormal trisomy 2 karyotype established by coculture of peripheral lymphocytes with an HTLV‐II‐infected simian leukocyte cell line

A new human T cell in with a chromosomal abnormality (47, XY, +2), designated AS‐IIA, was established by coculturing peripheral blood leukocytes of a healthy adult male with a lethally irradiated human T lymphotropic virus type II (HTLV‐II)‐infected simian leukocyted cell line (Si‐IIA). A polymerase chain reaction method showed that this interleukin‐2 (IL‐2)‐dependent cell line possessed the HTLV‐II provirus genome; the cells also reacted with HTLV‐II‐positive human sera, anti‐HTLV‐I/II p24, and anti‐HTLV‐II gp46 antibodies. AS‐IIA cells expressed the suppressor/cytotoxic T cell markers CD3+, CD4‐, CD25+, and HLA‐DR+, with later conversion ot CD8‐. These cells showed better proliferation than other human HTLV‐II‐infected cell lines with normal karyotypes, but were not transplantable into severe combined immunodeficiency mice. Virus production from AS‐IIA was confirmed not only by electron microscopic examination, which revealed mature and immature type C virus particels, but also by the capacity of the line to immortalize human T cells. These results suggest that HTLV‐II shows broad tropism for T cells including CD4+ or CD8+, and that not only SI‐IIA, but also AS‐IIA, are goode sources of HTLV‐II. The authors of the present study believe that AS‐IIA may be a useful human T cell line for the investigation of HTLV‐II in comarison with HTLV‐I.
Monocyte chemoattractant protein‐1 and coronary artery disease

The designation of atherosclerosis as a chronic inflammatory process represents an exciting and logical paradigm shift for cardiologists. Monocyte chemoattractant protein‐1 (MCP‐1) plays an important role in the recruitment and activation of monocytes and thus in the development of atherosclerosis. Enhanced MCP‐1 expression has been detected in macrophages, endothelial cells, and vascular smooth muscle cells in the atheromatous plaque. Activation of macrophages by MCP‐1 also appears to be involved in the vulnerability of the plaque. Indeed, circulating MCP‐1 levels are elevated in patients with acute myocardial infarction and in those with unstable angina, but not in patients with stable angina. Production of MCP‐1 and macrophage accumulation are also observed after coronary angioplasty or grafting, indicating that MCP‐1 expression may be related not only to instability of atheromatous plaques, but also to the formation of restenotic lesions. The development of therapeutic drugs for atherosclerosis targeted specially against MCP‐1 may be useful in the prevention of plaque formation and future myocardial infarction.
Visualization of Stone Trajectories in Live Curling Broadcasts using Online Machine Learning

We developed a system for visualizing stone trajectories in curling games for live broadcasts. Robustly tracking a moving stone from curling video sequences is difficult because the stone is frequently hidden by the brushes held by the players and the players' bodies during their sweeping actions. Although a number of methods for visual object tracking have been proposed, real-time tracking under heavy occlusion is still a challenging task. We thus propose an online machine learning method for tracking a curling stone to deal with changes in its appearance. The method creates a candidate-object image, which eliminates background noises, and is used as input to the kernelized correlation filter (KCF) tracker. Coordinate transformation is also applied to the system to improve its operability. Experimental results showed that our stone tracker is more accurate and faster than other conventional tracking methods. The developed system was used at All Japan Curling Championships 2017 to display stone trajectories during live broadcasts.
Random regret minimization or random utility maximization: An exploratory analysis in the context of automobile fuel choice

Interest in alternative behavioural paradigms to ra ndom utility maximisation (RUM) has existed ever since the dominance of the RUM formulation. One alternative is known as random regret minimisation (RRM), which suggests that when choosing between alternatives, decision-makers aim to minimise antic ipated regret. Although the idea of regret is not new, its incorporation into the same discrete choice framework of RUM is very recent. This paper is the first to apply the R RM-model framework to model choice among durable goods. Specifically, we estimate and compare RRM- and RUM-models in a stated choice context of choosing amongst petrol, diesel and hybrid fuelled vehicles (associated with specific levels of fuel efficiency and engine capacity). The RRM-model is found to achieve a marginally better fit (using a non-nested test of differences) than its equally parsimonious RUM-counterpart. As a second contribution, we derive a formulation for regret-based elasticities, and comp are utility- and regret-based elasticities in the context of stated vehicle-type choices. We f ind that in the context of our choicedata, mean estimates of elasticities are different for many of the attributes and alternatives.
Respiratory Disease in Agricultural Workers: Mortality and Morbidity Statistics

ABSTRACT To quantify the respiratory disease burden among agricultural workers, we examined the 1988–1998 National Center for Health Statistics (NCHS) “Multiple Cause of Death Data” and the 1988–1994 Third National Health and Nutrition Examination Survey data (NHANES III). Proportionate mortality ratios (PMRs) were determined for 11 respiratory conditions among 6 agricultural groups: crop farm workers, livestock farm workers, farm managers, landscape and horticultural workers, forestry workers, and fishery workers. Prevalence ratios (PRs) were determined for 12 respiratory conditions among 3 agricultural groups: farm workers, farm managers, and other agricultural workers. Disease categories groups were based on the 9th International Classification of Diseases and the agricultural groups on the NCHS or NHANES III industry and occupation codes, respectively. Crop farm workers and livestock farm workers had significantly elevated mortality for several respiratory conditions, with mortality for hypersensitivity pneumonitis being 10 and 50 times higher than expected. Landscape and horticultural workers had significantly elevated mortality for abscess of the lung and mediastinum and chronic airways obstruction. Forestry workers had significantly elevated mortality for pulmonary tuberculosis, chronic airways obstruction, and pneumonia. Prevalence of wheeze was elevated for female farm workers, shortness of breath was elevated for farm workers who had ever smoked, and hay fever was elevated for black, non-Hispanic farm workers. Prevalence of asthma was elevated for other agricultural workers who had ever smoked. Farm workers had a PR of 173 for obstructive respiratory abnormality. Continued improvement in occupational health surveillance systems for agriculture is essential to help guide prevention efforts for respiratory disease.
The impact of tillage and fertilization on Fusarium infection and mycotoxin production in wheat grains.

Fusarium head blight (FHB) is a worldwide disease of small grain cereals, which reduces grain yield and its quality. The aim of this study was to identify the influence of different tillage and fertilization practices on winter and spring wheat grain infection with Fusarium fungi and contamination by mycotoxins – deoxynivalenol (DON), zearalenone (ZEN) and T-2 toxin. A two-factor field experiment was carried out at the Lithuanian Institute of Agriculture during the period 2005–2008. The internal grain infection with Fusarium fungi were quantified using agar tests. Purified colonies were identified using different manuals. The mycotoxins were analyzed using ELISA method. Meteorological conditions were not conducive to Fusarium head blight development during the 2005–2008 period, therefore Fusarium infection level was very low in harvested winter wheat grain (0–7.1%) and moderate in spring wheat grains (27.3–41.3%). The concentrations of DON (<100–166.3 μg kg-1), ZEN (<10–10.8 μg kg-1) and T-2 toxin (<7.5–13.2 μg kg-1) in winter wheat grain samples most often were close to the limit of detection, while in spring wheat samples they were slightly higher. Tillage systems had no clearly evident influence on Fusarium infection level; however, some significant differences in the mycotoxin production were observed. The concentrations of DON (2008) and ZEN (2006 and 2008) in spring wheat and T-2 toxin (2006) in winter wheat significantly correlated with the number of productive tillers or number of plants m-2 and were significantly lower in no-tillage system. A significant influence of high fertilizer rates on spring wheat grain infection with Fusarium spp. was observed in 2007, and similar trends were found in 2006 and 2008. Higher concentrations of trichothecene producers were detected in the spring wheat grain from the conventionally tilled treatments applied with higher fertilizer rates.
Dried Venison Quality Parameters Changes during Storage

Authors : Laima Silina, Ilze Gramatina, Liga Skudra, Tatjana Rakcejeva Abstract : The aim of the current research was to determine quality parameters changes of dried venison during storage. Protein, fat and moisture content dynamics as well microbiological quality was analyzed. For the experiments the meat (0.02×4.00×7.00 cm) pieces were marinated in “teriyaki sauce” marinade (composition: teriyaki sauce, sweet and sour sauce, taco sauce, soy sauce, American BBQ sauce hickory, sesame oil, garlic, garlic salt, tabasco red pepper sauce) at 4±2°C temperature for 48±1h. Sodium monophosphate (E339) was also added in part of marinade to improve the meat textural properties. After marinating, meat samples were dried in microwave-vacuum drier MUSSON–1, packaged in vacuum pouches made from polymer film (PA/PE) with barrier properties and storage for 4 months at 18±1°C temperature in dark place. Dried venison samples were analyzed after 0, 35, 91 and 112 days of storage. During the storage total plate counts of dried venison samples significantly (p<0.05) increased. No significant differences in the content of protein, fat and moisture were detected when analyzing dried meat samples during storage and comparing them with the chemical parameters of just dried meat.
Impedance and dielectric studies of gel grown lead- iron mixed levo tartrate crystals

Various metal tartrate crystals find different applications. In the present study, the lead-iron mixed levo tartrate crystals with different compositions were grown by using silica hydro gels as the growth medium. Long, dendrite, white crystals were grown. From EDAX the exact composition of lead and iron was estimated in the grown crystals. The thermo- gravimetric analysis was carried out to assess the amount of water molecules associated with them. The FTIR spectroscopy study was carried out to identify the presence of various functional groups. The stoichiometric formulae of different composition of mixed Pb- Fe levo tartrate crystals were suggested. The impedance spectroscopic studies were carried out on pelletized samples in 100 Hz to 7 MHz range at room temperature. The variation of the real and imaginary part of impedance was studied with frequency of applied field. From the Nyquist plots and computer simulation of equivalent circuits the contribution of grain and grain boundary was revealed. The variation of dielectric constant and dielectric loss with frequency was also studied. The variation of ac conductivity with frequency has been discussed according to Jonscher's law.
Basal Extracellular Signal-Regulated Kinase Activity Modulates Cell-Cell and Cell-Matrix Interactions

ABSTRACT Suppression of the basal extracellular signal-regulated kinase (ERK) activity in PC12 cells markedly altered their phenotype. Wild-type cells grew in a dissociated pattern adherent to the substrate. The stable expression of an ERK inhibitory mutant resulted in the formation of calcium-dependent aggregates which were less adherent to the substrate. Concomitantly, the cells reorganized their actin cytoskeleton and increased their expression of several adherens junction proteins, particularly cadherin. Metabolic labeling demonstrated an increased synthesis of cadherin and β-catenin in these cells. Nontransfected PC12 cells and aras-transformed MDCK cell line also formed aggregates and increased their expression of adherens junction proteins following treatment with the selective MEK inhibitor PD98059. A peptide containing the HAV cadherin recognition sequence attenuated the aggregation. These studies suggest that in PC12 and epithelial cells, ERKs are pivotally positioned to enhance substrate interactions when active or to release homotypic interactions when suppressed.
Characterization of the major Epstein-Barr virus-specific RNA in Burkitt lymphoma-derived cells

Cytoplasmic RNA prepared from five lymphoid cell lines and a Burkitt lymphoma biopsy was radioactively labeled in vitro and hybridized to cloned EcoRI restriction endonuclease fragments of B95-8 Epstein-Barr virus DNA. The results confirmed that the most abundant cytoplasmic RNA species in such cells is specified by a small region of the genome defined by the EcoRI J fragment. Detailed mapping experiments precisely localized these transcripts within the sequence of the rightmost one-third of the EcoRI J fragment. DNA sequencing suggested that this region of the Epstein-Barr virus genome is unable to code for protein. The major early transcripts consisted of two non-polyadenylated RNA species, each about 170 nucleotides in length. They were both transcribed off the same strand of the DNA and showed significant sequence homology with each other. The coding sequences of the two small RNAs contained potential intragenic control regions for RNA polymerase III.
Evaluation of phytase concentration needed for growing–finishing commercial turkey toms

1. Growth performance, serum bone markers, and bone strength and mineralisation were determined in tom turkeys grown from 9 to 17 weeks of age. 2. Dietary non-phytate phosphorus was formulated to be reduced by 1·0 g/kg in the low phosphorus diet compared to a control diet and phytase was added to provide 0, 150, 300, 450 or 600 units/kg activity to the low phosphorus diet. 3. From 9 to 12 weeks of age, body weight and gain:food were reduced by the low phosphorus diet without added phytase, compared to the adequate phosphorus diet. Increasing the concentration of phytase linearly increased these growth parameters. There were no significant growth responses at 17 weeks of age. 4. Serum osteocalcin was reduced by increasing dietary phosphorus at 12 weeks of age when growth was affected, but not at later ages. Serum pyridinoline was reduced by higher dietary phosphorus and decreased linearly with increasing phytase activity at 17 weeks of age. 5. Fracture force of the ulna and femur increased linearly with increasing phytase activity but bone strength was not affected when corrected for bone cross-sectional area. Bone strength of the ulna and ash concentration of the ulna and tibia were increased by higher dietary phosphorus. Humerus and ulna ash increased linearly with increasing phytase activity. 6. Water-soluble phosphorus content of the litter was increased by higher dietary phosphorus and addition of phytase to the low phosphorus diet. The increase in water-soluble phosphorus content of the litter when phytase was fed may indicate that phosphorus could be fed at a lower concentration than used in this trial, at least in the finisher diet when phytase is added to the food. 7. Bone fracture force, strength and ash were generally optimised when 450 units/kg phytase activity was added to the low phosphorus diet. However, growth performance was best in the grower I (9 to 12 weeks) phase when 600 units/kg phytase was added to the diet.
Filtration membrane with ultra-high porosity and pore size controllability fabricated by parylene c molding technique for targeted cell separation from bronchoalveolar lavage fluid (BALF)

This paper presented an effective fabrication strategy to prepare micropore arrayed membrane with ultra-high porosity and pore size controllability based on a Parylene C molding technique. The prepared filtration membrane had small supporting structure between adjacent micropores with width of 4 μm and thereby an ultra-high porosity up to 90.9%. The membrane was 10 μm thick and had a considerable mechanical strength. The aspect ratio even went to 7.5 in small micropore devices (pore size of 1.39 ± 0.067 μm). Bronchoalveolar lavage fluid (BALF) with sparked rare cancer cells was sequentially filtrated through membranes with different pore sizes in an integrated device. The preliminary results indicated that the present multiplex filtration device can get a high targeted cell separation yield of 96.5% and purity of 100% with throughput as high as 2 mL/min.
Adaptation of Refactoring Strategies to Multiple Axes of Modularity: Characteristics and Criteria

In object-oriented programming, the adoption of modules as mixins provides a second axis of modularity. Furthermore, support for aspect-oriented programming introduces a third such axis. In this paper we define criteria under which a feature should be placed in a given unit of modularity and investigate the degree to which the presence of multiple dimensions of modularity affects existing refactoring strategies. We reason about the dilemmas involved and we provide guidelines for applying existing refactoring strategies in order to support the above criteria. We adopt Ruby and Aquarium as example technologies in order to provide an environment with classes, modules and aspects.
Fatal Cokeromyces recurvatus Pneumonia: Report of a Case Highlighting the Potential for Histopathologic Misdiagnosis as Coccidioides

Cokeromyces recurvatus is a dimorphic zygomycete with histologic morphology similar to Coccidioides immitis. A 66-year-old man who was status-post bone marrow transplantation for chronic myelogenous leukemia was hospitalized with new onset rash, nausea, and vomiting and subsequently expired. A sputum culture collected on the day of death revealed heavy growth of C. recurvatus 6 days after collection. At autopsy, microscopic examination of the lungs revealed numerous thick-walled, nonbudding spherules ranging in size from 40 to 80 µm. Initial immunohistochemical staining of the formalin-fixed lung tissue was positive for Coccidioides . Additional immunoperoxidase staining revealed the organisms were consistent with a zygomycete fungus, compatible with C. recurvatus infection. Polymerase chain reaction using panfungal primers was attempted on the formalin-fixed tissue but was inconclusive. This case highlights the potential for misdiagnosing Cokeromyces as Coccidioides when the diagnosis is based on histology and immunohistochemical staining.
Current Issues in Sports Nutrition in Athletes

Annotation: The benefits of sports nutrition evaluation and counseling are important to both elite athletes and active men and women of all ages who want to optimize health and performance. Proper nutrition is essential to staying metabolically healthy during a run, a draining practice, or as a year-round philosophy to perform maximally and to avoid or recover from injury. Major issues related to nutrition in sports include weight control, body composition, carbohydrate loading, hydration, eating disorders, and supplementation, to name a few. General sports nutrition guidelines and sports-specific concerns are reviewed.
Phase-type distributions for realistic modelling in discrete-event simulation

Phase-type (PH) distributions are a valuable tool for representing real-world phenomena such as failure-times or response-times in an analytically tractable way. Recently, the application of phase-type distributions in simulation has received increasing attention. In simulation, phase-type distributions enable good representation of empirical distributions, even if the data does not follow one of the well-known statistical distributions. Furthermore, since phase-type distributions have Markovian representations, analytical approaches can be used to support simulation results. So far, however, well-known discrete-event simulators do not support PH distributions. In this paper we introduce the libphprng library for generating random-variates from PH distributions. Libphprng combines efficient methods with easy usage. Furthermore, libphrng integrates seamlessly with discrete-event simulators such as OMNeT++ without any changes to the library core.