Miracle-dz/UniFAR-FTUs huggingface dataset:
Controlled Hypotension With Adenosine or Sodium Nitroprusside During Cerebral Aneurysm Surgery: Effects on Renal Hemodynamics, Excretory Function, and Renin Release

Adenosine, a potent vasodilator both in animals and in humans, has been used to produce controlled hypotension in patients, especially during cerebral aneurysm surgery. However, in animals adenosine by intrarenal infusion decreases renal blood flow (RBF), glomerular filtration rate (GFR), urine flow, and causes an inhibition of renin secretion. In this study we evaluated the effect of adenosine on RBF in patients (n = 15) scheduled for cerebral aneurysm surgery who had been anesthetized with a modified neurolept-anesthesia during controlled hyperventilation. Perioperative hypotension was achieved with infusion of adenosine (252.8 ± 55.8μg · kg−1 · min−1) (n = 8) or sodium nitroprusside (2.5 ± 0.8μg · kg−1 · min−1) (n = 7). Mean arterial pressure was lowered by 25%–30%, to approximately 60–70 mm Hg, in both groups. Glomerular filtration rate and RBF were measured using standard renal clearance methods for 51Cr-ethylenediaminetetraacetic acid and paraaminohippuric acid. Urine and blood samples were collected during normotension before and after a bolus dose of hypertonic mannitol, during hypotension, and during normotension after clipping of the aneurysm. Adenosine induced a marked decrease in GFR (−91%) and RBF (−92%), and a pronounced increase in renal vascular resistance. Sodium nitroprusside caused a significantly (P < 0.01) less pronounced decrease in GFR (−24%) and RBF (−36%), but did not affect renal vascular resistance. After discontinuation of the hypotensive agents, GFR returned to baseline levels in both groups. Renal blood flow, however, increased above baseline after discontinuation of adenosine (+93%) but not after sodium nitroprusside. Sodium nitroprusside increased renin secretion, which was not seen with adenosine. Four patients in the adenosine group developed reversible atrioventricular conduction disturbances. We conclude that adenosine-induced hypotension during cerebral aneurysm surgery prevents renin release and induces a reversible renal vasoconstriction mainly involving preglomerular resistance vessels and thereby decreasing RBF and GFR.
Assessing Internet Use in Florida Newsrooms

The Internet has become a major factor in the mass media industry. As a consequence, information sources, including agricultural communicators, are considering the decision to move to Web-based publications and publicity dissemination tools. Rural and agricultural audiences, however, have favored traditional media as a source of news and information, creating something of a “rural-urban digital divide. ” In an attempt to assess how mass media news operations are utilizing the Web as a newsgathering and information source, a statewide descriptive survey was conducted of a random sample of local and regional media outlets. Results showed that television, radio, and newspaper newsrooms were using computers and the Internet extensively not only for receiving information and research but also for disseminating news. Respondents indicated that 88.9% of reporters used the Internet on a daily basis, while 72.2% of news units maintain an online presence. These findings indicate that as media outlets increase their utilization of the Web, agricultural industries and higher education institutions need to move more to electronic dissemination of information. This research is available in Journal of Applied Communications: https://newprairiepress.org/jac/vol89/iss2/3
Arousal from sedation in wake-up tests requires careful risk stratification.

I t is generally advocated to stop sedation daily in modern intensive care medicine. A protocol-based control of sedation in conjunction with established scales (1–3) and the use of modern compounds with short halflives (4) is to the benefit of critically ill patients (5, 6) by reducing the amount of administered drugs, decreasing length of withdrawal symptoms, diminishing duration of arousal, increasing successful extubation rate, and decreasing length of hospitalization, duration of ventilatory support, and expenses. This simple and important concept, however, is overshadowed by nebulous comprehension of sleep and sedation, awakening, and arousal, which unfortunately are equalized in daily routine. Stopping sedation is understood as awakening, while in reality it is more an arousal reaction incomparable to a normal wake-up response from physiologic sleep. In this context, several questions must be considered:
Prevention of Diabetes in BB/Wor Rat by Single Transfusion of Spleen Cells: Parameters That Affect Degree of Protection

Previous studies have shown that multiple transfusions of spleen cells from histocompatible nondiabetic donors prevent autoimmune diabetes mellitus in diabetes-prone (DP) BioBreeding/Worcester (BB/Wor) rats. In this study, a single transfusion of ≥50 × 106 cells from either diabetes-resistant (DR) BB/Wor or Wistar-Furth (WF) rats substantially reduced the incidence of diabetes when given to DP rats 27 or 46 days old but not 61 days old. Transfusion and protection were associated with the appearance of RT6+ donor lymph node cells in recipient rats. In vivo depletion of RT6+ T-lymphocytes in 150-day-old protected animals did not produce diabetes. DR BB/Wor and WF spleen cells were equally efficacious when given either intraperitoneally or intravenously. Mitogen-activated spleen cells were relatively less effective than untreated cells. We conclude that BB rat diabetes can be prevented by one transfusion of spleen cells from histocompatible DR and WF donors, and that the protective effect is dependent on recipient age and cell dose. The effect may be mediated by a population of RT6+ T-lymphocytes that, during a critical developmental period, regulate the expression of autoimmunity in these animals.
Human Localization by acceleration sensors located on the floor in a home environment

Recent advances in information communication technologies have yielded a variety of new services. Location based services are attractive as they offer so many new functionalities. However, if they are used indoors, location recognition is essential because the global positioning system, the preferred choice outdoors, cannot be used indoors. Therefore, this paper proposes an indoor human location recognition method that uses the vibration signals captured by acceleration sensors placed on the floor. The user does not wear any device. Preliminary experiments show that signal magnitude corresponds to the distance between the sensor and the point of pressure which indicates the feasibility of the proposal. Another experiment with walking subjects showed that for subject-sensor distances of 1 to 5 m, the proposed method could recognize subject location with 68 % accuracy at distances of 1 m or better tolerance and 87 % at distances of 2 m or better tolerance. These results verify the feasibility of the proposed system.
Factors contributing to the success of crowdfunding: the Malaysian case

Crowdfunding is getting the world's attention due to the fact that it is particularly useful to support the development of new ideas and initiatives that cannot be funded by traditional mode of financing such as financing from financial institutions. Being globally recognized as the next best alternative for entrepreneurs to raise funds, it is highly important to discover the factors contributing to the success of raising funds through this mechanism. Based on interviews with major industry players, this research critically address the issues associated with crowdfunding and presents the factors mostly important for project owners or entrepreneurs to consider before engaging in raising funds through the crowdfunding platforms, in Malaysia. Apart from enriching the literature in crowdfunding, this research is expected to spur awareness on the importance and implications of crowdfunding in the Malaysian capital market.
Do Compensation Consultants Enable Higher CEO Pay? New Evidence from Recent Disclosure Rule Changes

We examine the impact of a firm’s compensation consultant choice on executive compensation by taking advantage of a 2009 SEC requirement that firms disclose fees paid to compensation consultants for both consulting and other services. We show that the disclosure rule change acted as a separating mechanism distinguishing firms that used compensation consultants to extract rents from shareholders from firms that used consultants to optimally set pay. We conclude that not all multi-service consultants are conflicted while not all specialist consultants are guardians of shareholder value. Our study provides a more nuanced view of the link between compensation consultant choices and executive pay.
Citations from the Literature

Mkrosnrgkal epididymovasostomy in the treatment of occlusive azoospennia Fogdestam I; Fall M; Nilsson S Sahlgrenska sjukhuset, University of Goteborg, Goteborg, Sweden FERTIL. STERIL. ; 46/5 (925-929) 1986 In principle, azoospermia has two explanations: occlusion of the duct system and serious dysfunction of the testicular parenchyma. Some cases of duct occlusion are suitable for reconstructive surgery. The authors describe a reconstructive technique based on full mobilization of a single loop of the epididymal duct as caudally as possible with two-layer sideto-end anastomosis, to the vas deferens. To ensure follow-up evaluation of each anastomosis, unilateral anastomosis was done primarily. In a few cases, cross-over anastomosis was necessary. In cases of reoperation, if possible, this was performed on the same side. When the epididymal duct was found empty, the contralateral epididymis was explored. Patients with postoperative oligozoospermia were offered a supplementary contralateral operation. From 1980 to 1984, 41 patients underwent epididymovasostomy. At follow-up evaluation. 35 (85%) presented sperms in repeated tests. Fifteen of these patients (37%) have fathered children. Patients with postoperative normospermia and no antisperm antibodies had an excellent fertility prognosis. The singleloop dissection technique provides anatomic specificity and a high percentage of patent anastomoses and does not interfere with the possibilities of reoperation.
Do Indicated Preventive Interventions for Depression Represent Good Value for Money?

Objective: The prevention of depression is of growing interest to researchers and policy makers. However, the question of whether interventions designed to prevent depression provide value for money at a population level remains largely unanswered. The current study assesses the cost-effectiveness of two indicated interventions designed to prevent depression: a brief psychological intervention based on bibliotherapy and a more comprehensive group-based psychological intervention following opportunistic screening for sub-syndromal depression in general practice. Method: Economic modelling using a cost utility framework was used to assess the incremental cost effectiveness ratios (ICERs) of the two interventions within the Australian population context, modelled as add-ons to current practice. The perspective was the health sector and outcomes were measured using disability-adjusted life years (DALYs). Uncertainty was measured using probabilistic uncertainty testing and important model assumptions were tested using univariate sensitivity testing. Results: The brief bibliotherapy intervention had an ICER of AU$8600 per DALY and the group-based psychological intervention had an ICER of AU$20 000 per DALY. The majority of the uncertainty simulations for both interventions fell below the cost-effectiveness threshold value of $50 000 per DALY. Extensive sensitivity testing showed that the results were robust to the assumptions made in the analyses. Conclusions: Following screening in general practice, both psychological interventions, particularly brief bibliotherapy, appear to be good value for money and worthy of further evaluation under routine care circumstances. Acceptability issues associated with such interventions, particularly to primary care practitioners as providers of the interventions and health system administrators, also need to be considered before wide-scale adoption is contemplated.
Diagnosis of internal derangement of the knee at 3.0-T MR imaging: 3D isotropic intermediate-weighted versus 2D sequences.

PURPOSE To compare three-dimensional (3D) isotropic fast spin-echo (SE) intermediate-weighted magnetic resonance (MR) imaging with two-dimensional (2D) fast SE MR imaging-both performed at 3.0 T-for performance in the diagnosis of internal derangements of the knee. MATERIALS AND METHODS The institutional review board approved this HIPAA-compliant study, and the requirement for informed consent was waived. The authors retrospectively reviewed 87 knee MR images obtained in 85 patients who had undergone both 3D isotropic and 2D MR examinations of the knee at 3.0 T and subsequent arthroscopic surgery. The 2D MR images included intermediate-weighted coronal and sagittal images, intermediate-weighted axial images with fat saturation, and T2-weighted sagittal images. The 3D isotropic MR images were obtained with multiplanar reformation (MPR), a fast SE intermediate-weighted sequence, and a reconstruction voxel size of 0.5 x 0.5 x 0.5 mm. Two radiologists retrospectively and independently evaluated the 2D and 3D data sets, at different sessions, for the presence of medial meniscus (MM), lateral meniscus (LM), anterior cruciate ligament (ACL), and posterior cruciate ligament (PCL) tears. These interpretations were compared with the arthroscopic surgery findings. The statistical differences between the sensitivities, specificities, and accuracies of the two methods were determined at McNemar testing, with surgical findings serving as the reference standard. Interobserver agreement was calculated by using kappa coefficients. RESULTS For both reviewers, the sensitivity, specificity, and accuracy of both MR techniques were higher than 95% for the diagnosis of ACL and PCL tears, higher than 85% for the diagnosis of MM tears, and higher than 80% for the diagnosis of LM tears. There were no significant differences in sensitivity, specificity, or accuracy between the two methods. Interobserver agreement for evaluation of all lesions was excellent and ranged from 0.81 (LM tears evaluated with 3D and 2D sequences) to 0.93 (ACL tears evaluated with 3D and 2D sequences, PCL tears evaluated with 2D sequence, and MM tears evaluated with 3D sequence). CONCLUSION The performance of 3D isotropic fast SE intermediate-weighted MR imaging with MPR was not significantly different from that of 2D MR imaging in the diagnosis of cruciate ligament and meniscal tears of the knee.
Regulation of affect in late adulthood: Effects of mild depressive symptoms

Background: Recent research has highlighted the important role of emotion dysregulation in the occurrence and maintenance of depressive symptomatology. Objectives: The purpose of this study was to test the effects of mild depressive symptoms (MDS) on older adults’ ability to regulate emotional experiences. Method: A total of 70 community dwelling older adults completed self-report measures of affect and were asked to report how often they use specific emotion regulation strategies. Results: Consistent with previous theories older adults experiencing MDS reported greater difficulties in regulating affect compared to normal controls (NCs). Conclusion: The present results provide support for previous findings demonstrating that experiencing depressive symptoms affects the ability to regulate emotional responses. Current findings are likely to be informative in terms of understanding emotion dysregulation in older adults at risk of experiencing clinical symptoms of depression.
Comparison of Methods for Image-Based Profiling of Cellular Morphological Responses to Small-Molecule Treatment

Quantitative microscopy has proven a versatile and powerful phenotypic screening technique. Recently, image-based profiling has shown promise as a means for broadly characterizing molecules’ effects on cells in several drug-discovery applications, including target-agnostic screening and predicting a compound’s mechanism of action (MOA). Several profiling methods have been proposed, but little is known about their comparative performance, impeding the wider adoption and further development of image-based profiling. We compared these methods by applying them to a widely applicable assay of cultured cells and measuring the ability of each method to predict the MOA of a compendium of drugs. A very simple method that is based on population means performed as well as methods designed to take advantage of the measurements of individual cells. This is surprising because many treatments induced a heterogeneous phenotypic response across the cell population in each sample. Another simple method, which performs factor analysis on the cellular measurements before averaging them, provided substantial improvement and was able to predict MOA correctly for 94% of the treatments in our ground-truth set. To facilitate the ready application and future development of image-based phenotypic profiling methods, we provide our complete ground-truth and test data sets, as well as open-source implementations of the various methods in a common software framework.
A 32 GHz 20 dBm-PSAT transformer-based Doherty power amplifier for multi-Gb/s 5G applications in 28 nm bulk CMOS

This paper presents a 32 GHz transformer-based Doherty power amplifier (PA) in a 28 nm bulk CMOS process. There are two techniques proposed: linearization by means of AM-PM and AM-AM compensation of the class AB and the class C amplifiers; and parallel-series-parallel power power combiner, wherein a current-mode parallel combiner complements the Doherty's voltage-mode series combiner to boost the output power. A saturated output power (PSAT ) of 19.8 dBm and an OP1dB of 16 dBm are accomplished from 1V supply while supporting 15 Gb/s 64-QAM amplification at 11.7 dBm average output power. The chip achieves 21% PAE at PSAT and occupies 0.59 mm2 active area.
Crystal structure of human seminal diferric lactoferrin at 3.4 Å resolution

Lactoferrin was purified from human seminal fluid obtained from the semen bank. The purified samples were saturated with Fe 3+ and crystallized by microdialysis method. The crystals belong to orthorhombic space group P212121 with a = 55.9 A, b = 97.2 A, c = 156.1 A and Z = 4. The structure was determined with molecular replacement method and refined to an R factor of 18.7% for all the data to 3.4 A resolution. The overall structure of seminal lactoferrin is similar to human colostrum lactoferrin. The amino acid sequence of seminal lactoferrin shows that it has one amino acid less than human colostrum lactoferrin and the structure of its N-terminal region is far more ordered than other lactoferrins. The structure of the iron- binding site and its immediate surroundings indicate well defined features. Lactoferrin an 80 kDa, single-chain, iron-binding glycoprotein consists of two similar sized homologous N and C lobes, which are further divided into two similar sized domains: N1 and N2 in the N-lobe and C1 and C2 in the C-lobe. The iron-binding sites are located within the interdomain cleft of each lobe. It has the ability to bind, very tightly but reversibly, two Fe 3+ ions, together with two CO3 2− ions. The synergistic relationship between metal binding and anion binding is one of its unique features
Prognostic implications of karyotype and morphology in patients with non‐Hodgkin's lymphoma

Clonal chromosome abnormalities were observed in 30 patients with non‐Hodgkin's lymphoma; the type of lymphoma was characterized on the basis of the International Working Formulation. The 30 patients were classified into five groups according to the chromosome abnormality. There were 8 patients with t(14;18), 3 with t(8;14), 7 with a translocation to the long arm of chromosome 3 (a 3q+ chromosome), 5 with near‐tetraptoidy, and 7 with other abnormalities. Among the 8 patients with t(14;18), 5 had follicular small cleaved‐cell lymphoma (FSC), I had follicular mixed cell lymphoma (FM), and 2 had diffuse large‐cell lymphoma (DL); the diagnosis in these 2 patients was based on extranodal tissue. All 3 patients with t(8;14) had DL and B‐cell markers. Except for I patient, all those with a 3q+ chromosome had DL; 4 of those who were tested had B‐cell or pre‐B‐cell markers. Four of the 5 patients with near‐tetraploidy had follicular mixed‐cell lymphoma, and 2 of the 7 patients with other abnormalities had T‐cell lymphoma. Thus, patients with a t(8;14), a 14q+ chromosome, or a 3q+ chromosome all tend to have diffuse large‐cell lymphoma, usually of the non‐cleaved type. On the other hand, our data suggest that patients with FSC generally have a t(14;18) whereas those with follicular and diffuse mixed small cleaved cells and large non‐cleaved cells have a different pattern with modal chromosome numbers in the tetraploid range. We added 17 previously reported patients to the 30 presented here and correlated the karyotype with survival. The 6 patients with near‐tetraploidy had the longest median survival, 69 months, the 15 patients with t(14;18) had the next longest, 48 months. The 4 patients with (8;14) had Che shortest urvival, 12 months, and the 9 with other abnormalities had the next shortest, 17 months. Intermediate survivals of 27 and 30 months were observed in patients with a 14q+ or a 3q+ chromosome, respectively. The median survival of thaw various categories differs and our data, thus, indicate that the karyotypic pattern of the malignant cell may be a significant independent prognostic feature influencing the survival of patients with non‐Hodgkin's lymphoma.
Theoretical study on torsional strengthening of multi-cell RC box girders

A new analytical method to predict the torsional capacity and behavior of R.C multi-cell box girders strengthened with carbon fiber reinforced polymer (CFRP) sheets is presented. Modification was done on the Softened Truss Model (STM) in the proposed method; the concrete torsional problem is solved by combining the equilibrium conditions, compatibility conditions and constitutive laws of materials by taking into account the confinement of concrete with CFRP sheets. A specific algorithm is developed to predict the torsional behavior of reinforced concrete multi-cell box girders with or without strengthening by CFRP sheets. Applications of the developed method as an assessment tool to strengthened multicell box girders with CFRP and first analytical example that demonstrate the contribution of the CFRP materials on the torsional response is also included. Keywords—Carbon fiber reinforced polymer, Concrete torsion, Modified Softened Truss Model, Multi-Cell box girder.