Miracle-dz/UniFAR-FTUs huggingface dataset:
Noninvasive Antenatal Diagnosis of Fetal RhD Status

Introduction: Fetal cell-free nucleic acids within the blood stream of a pregnant woman come from fetal genetic material which can be acquired by simple venipuncture that reduces any risk to a minimum. Fetal the period from the 12 th gestation week until the 31 gestation week. The biological fathers of all 30 fetuses were phenotyped as heterozygote to the RhD antigen. The results showed that 30% of the fetuses are RhD negative, and 70% are RhD positive. Conclusion: The noninvasive fetal RhD genotyping is not only one precious tool in the management of RhD alloimmunised pregnancies, but it also allows antenatal anti-D immunoglobulin prophylaxis exclusiveness for only non-immunized RhD pregnant women carrying RhD positive fetus. Taking into consideration that 30% of the RhD negative pregnant women that carry a RhD negative fetus receive antenatal RhIG prophylaxis with no absolute need for it. At RhD alloimmunised pregnant women the noninvasive genotyping of the fetal blood group enables an easy and safe method in determination of a fetal risk from a hemolytic disease, and at the same time evading a vast laboratory and clinical monitoring of RhD antigen-negative fetal cases.
To What Extent Is Social Marketing Used in Demand Reduction Campaigns for Illegal Wildlife Products? Insights From Elephant Ivory and Rhino Horn

The illegal wildlife trade is a global threat to biodiversity as well as to public health and good governance. As legislation and law enforcement have been insufficient to protect many wildlife species, conservationists are increasingly focused on campaigns to help reduce demand for wildlife products. Social marketing is increasingly being used to support biodiversity conservation efforts, but the extent of its use has seldom been researched. Based on interviews with conservation practitioners, we assess the extent to which social marketing has been used in demand reduction campaign design. We do this by investigating the level to which demand reduction campaigns met the benchmarks defined by the UK’s National Social Marketing Centre. We focus on rhino horn and elephant ivory, two high-profile products in the illegal wildlife trade and in China and Vietnam given their role as key consumer countries. We also investigate how conservation practitioners view the opportunities and challenges of using social marketing in the context of reducing demand for illegally traded wildlife products. Our findings highlight that there are substantial gaps between best practice in social marketing and current practices in the design of demand reduction campaigns. However, several elements of social marketing are widely utilized and a platform exists from which to build more comprehensive behavioral influence campaigns in future. In terms of future needs, practitioners highlighted the need for independent consumer research upon which to build target audience insights, a focus on broader audience segments beyond the product consumers, and the improvement of collaborations across institutions.
Combining Real-Time Ratings With Qualitative Interviews to Develop a Smoking Cessation Text Messaging Program for Primary Care Patients

Background Text messaging (short message service, SMS) interventions show promise as a way to help cigarette smokers quit. Few studies have examined the effectiveness of text messaging (SMS) programs targeting smokers associated with primary care or hospital settings. Objective This study aimed to develop a text messaging (SMS) program targeting primary care smokers. Methods Adult smokers in primary care were recruited from February 2017 to April 2017. We sent patients 10 to 11 draft text messages (SMS) over 2 days and asked them to rate each message in real time. Patients were interviewed daily by telephone to discuss ratings, message preferences, and previous experiences with nicotine replacement therapy (NRT). Content analysis of interviews was directed by a step-wise text messaging (SMS) intervention development process and the Information-Motivation-Behavioral Skills model of medication adherence. Results We sent 149 text messages (SMS) to 15 patients. They replied with ratings for 93% (139/149) of the messages: 134 (96%, 134/139) were rated as clear or useful and 5 (4%, 5/139) as unclear or not useful. Patients’ preferences included the addition of graphics, electronic cigarette (e-cigarette) content, and use of first names. Regarding NRT, patients identified informational gaps around safety and effectiveness, preferred positively framed motivational messages, and needed behavioral skills to dose and dispose of NRT. Conclusions Patients recommended text message (SMS) personalization, inclusion of e-cigarette information and graphics, and identified barriers to NRT use. Combining real-time ratings with telephone interviews is a feasible method for incorporating primary care patients’ preferences into a behavioral text messaging (SMS) program.
Tepotinib in Non-Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations.

BACKGROUND A splice-site mutation that results in a loss of transcription of exon 14 in the oncogenic driver MET occurs in 3 to 4% of patients with non-small-cell lung cancer (NSCLC). We evaluated the efficacy and safety of tepotinib, a highly selective MET inhibitor, in this patient population. METHODS In this open-label, phase 2 study, we administered tepotinib (at a dose of 500 mg) once daily in patients with advanced or metastatic NSCLC with a confirmed MET exon 14 skipping mutation. The primary end point was the objective response by independent review among patients who had undergone at least 9 months of follow-up. The response was also analyzed according to whether the presence of a MET exon 14 skipping mutation was detected on liquid biopsy or tissue biopsy. RESULTS As of January 1, 2020, a total of 152 patients had received tepotinib, and 99 patients had been followed for at least 9 months. The response rate by independent review was 46% (95% confidence interval [CI], 36 to 57), with a median duration of response of 11.1 months (95% CI, 7.2 to could not be estimated) in the combined-biopsy group. The response rate was 48% (95% CI, 36 to 61) among 66 patients in the liquid-biopsy group and 50% (95% CI, 37 to 63) among 60 patients in the tissue-biopsy group; 27 patients had positive results according to both methods. The investigator-assessed response rate was 56% (95% CI, 45 to 66) and was similar regardless of the previous therapy received for advanced or metastatic disease. Adverse events of grade 3 or higher that were considered by investigators to be related to tepotinib therapy were reported in 28% of the patients, including peripheral edema in 7%. Adverse events led to permanent discontinuation of tepotinib in 11% of the patients. A molecular response, as measured in circulating free DNA, was observed in 67% of the patients with matched liquid-biopsy samples at baseline and during treatment. CONCLUSIONS Among patients with advanced NSCLC with a confirmed MET exon 14 skipping mutation, the use of tepotinib was associated with a partial response in approximately half the patients. Peripheral edema was the main toxic effect of grade 3 or higher. (Funded by Merck [Darmstadt, Germany]; VISION ClinicalTrials.gov number, NCT02864992.).
Risk factors for piglet mortality in Danish organic sow herds

High piglet mortality is a considerable problem in Danish organic sow herds. The aim of this study was to determine causes of preweaning mortality and to identify risk factors for piglet mortality within the Danish organic pig production. A large-scale study was performed in nine commercial Danish organic sow herds during a one-year period. Data included recordings on piglet mortality in 6000 litters. Moreover, 3000 piglets were necropsied in order to determine the cause of death. The results indicates that it is possible to achieve a lower piglet mortality in the future and that the Danish organic pig production and a high piglet mortality is not inevitably synonymous.
Predictors of Knowledge Towards Menstruation inEthiopia

Menstruation is a physiological process that reproductive age group women will pass through. Due to myth and misconception about it, menstruation is considered as being unhealthy and impurity. Therefore, the study was aimed at assessing the level of knowledge and associated factors. A cross-sectional study design was used. Randomly selected 422 female students were involved. Binary and multivariable logistic regressions conducted using statistical Package for Social Sciences (SPSS) version 20. P-value less than 0.05 was taken as a significant association. The study revealed that 90.7% of the respondents scored high level of knowledge towards menstruation. Age of the respondents (AOR= 3.573, 95% CI= 1.440, 8.861), use of medication without consultation of the health personnel (AOR=3.081, CI: 1.385, 6.851) and being informed about menstruation before menarche (AOR= 0.326, 95% CI: 0.137, 0.778) were significantly associated with high level of knowledge towards menstruation. The study had shown that most of the respondents scored high level of knowledge about menstruation. Age of the respondents and those who used medication with consultation of health personnel and being informed about menstruation before menarche were associated with high level of knowledge towards menstruation.
Misdiagnosis of Primary Urethral Condyloma Acuminata with Papillary Cancer: a Case Report

: Our purpose in this case report is to pay attention to an unusual presentation of HPV infection. A 27-year-old-male patient with the complaint of dysuria, hematuria, and urethral lesion was presented to the clinic. The first diagnosis was papillary urethral cancer based on the pathology report. We considered another expert's opinion from a pathologist point of view due to the report of a rare cancer for this young patient. The slides review showed no dysplastic change and confirmed condylomata acuminata. Primary urethral condyloma acuminata is rare and health care professionals should consider a thorough medical history, especially high-risk sexual behaviors of patients. Considering the risk of anogenital cancers, the type of HPV virus should also be determined in the patients.
Depression, anxiety and stress among diabetic and non-diabetic patients with periodontitis

The aim of this study is to determine the prevalence and severity of depression, anxiety and stress among diabetic patients with periodontitis and to assess the association of emotional disturbances with the severity of periodontitis. A total of 72 diabetic patients with periodontitis and 87 non diabetic patients with periodontitis who attended Kulliyyah of Dentistry periodontics clinic, International Islamic University Malaysia were randomly selected. The patients underwent a full-mouth clinical examination by a periodontics specialist. The prevalence and severity of depressive, anxiety and stress symptoms (DAS) were assessed among those patients by using the self-rating Malay version of the Depression Anxiety and Stress Scale (DASS-21). Diabetic patients had higher rates of depression 27.7%, anxiety 50% and stress 34.8% compared to the non-diabetic group rate of 11.4%, 25.3% and 6.8% respectively. More diabetic patients showed clinically significant DAS than the non-diabetic group indicating more severe emotional disturbances. The mean scores of DAS among the diabetic group were significantly higher (p<0.05) than non-diabetics. The mean scores of DAS were also higher among patients with advanced periodontitis than mild periodontitis. Emotional disturbances are occurring in a high rate in diabetic patients with periodontitis which can affect the severity of the periodontitis. Managing diabetic patients need to be more comprehensive by focusing on the psychological as well as the physical wellbeing of the patients leading to more efficient treatment of diabetes and its complications
Knowledge Level Influence In Protective Attitudes And Practices Against The Risk Of HIV/AIDS In Students Of Private Peruvian High Schools

Objective: To determine the influence of knowledge on protective attitudes and practices against the risk of HIV/AIDS in Peruvian students from exclusively private schools from the three regions of the country. Methodology: Following a correlational-comparative design, a sample of 849 Peruvian students from 52 private high schools was selected using cluster, stratified, and systematic sampling. Data was collected from adolescents and parents who signed informed consents, and was analyzed using the Kruskal-Wallis test and Spearman correlations. Results: Results indicate that the level of knowledge influences attitudes but not protective practices against the risk of HIV/AIDS (r =. 218, pConclusions: Private school students’ knowledge about HIV/AIDS shows a highly significant influence (p
Molecular Detection of Rubella Virus Glycoprotein Among Women of Childbearing Age in Lokoja

Background : The gene order for the Rubella virus (RV) 40S RNA is 5' -p150-p90-C-E2-E1-3' and the complete nucleotide sequence of RV has been determined for three strains. The RV core is surrounded by a host-derived lipid bilayer containing 5-6nm long spikes composed of the E2 and E1 glycoproteins Objective(s) : Molecular detection of Rubella virus glycoprotein after serum screening of 240 women attending Federal Medical Centre Lokoja (FMC) via IgG and IgM ELISA. Method : Cross-sectional study was carried out in Obstetrics and Gynecology clinic at FMC Lokoja. Serology for anti RV-IgG and IgM was done for 240 blood samples after serum separation. Polymerase Chain Reaction (PCR) was done for rubella cDNA via RUB 2 & 7 and RUB 8 & 11 specific primers and this was sequenced using dye terminator cycle sequencing. Result : 231(96.25%) of 240 and 4(1.7%) of 231 subjects were positive to Rubella IgG and IgM respectively after assay. PCR band result had 320bp on 1kb DNA plus ladder of 0. 9μg/lane and live blast of the 320 length sequence result revealed a Rubella membrane glycoprotein E1 (Rubella_E1). All subjects that had blood transfusion were positive to Rub-IgG (p=0.566) while 3(1.6%) of 168(88.9%) respondents with no blood transfusion were IgM positive (P= 0.537). 61(32.6%) of 67(35.8%) respondent who reported history of rash were positive to Rub-IgG (p=0.057) and of 30(22.7%) that has had a miscarriage, 29(22.0%) was positive to Rub-IgG (p=0.731) Conclusion : Rubella virus membrane glycoprotein E1, an important structural type 1 membrane protein in the entire pathogenesis of rubella virus has been confirmed in this locality.
HIV/AIDS Awareness Campaign through Sports in Yangon: The Pioneering Service-Learning Program of Dagon University, Myanmar

Rapid sports programs and activities have served as an avenue to unify people of diverse backgrounds and persuasions. More than promoting national or local pride and contributing to friendship, sportsmanship and social unity, sports also serves as a tool to popularize certain advocacies. Dagon University in Myanmar took advantage of this value of sports when it implemented “Playing Football, Learning HIV AIDS”, ―A Football for Development” program, a pioneering Service-Learning Program focused on utilizing football training activities as a tool for social action through HIV/AIDS information and education campaign for school children in 2015. In a country where about 220 000 people are living with HIV/AIDS, including 77 000 women, sports can be used for social action to increase awareness. This paper looks into the pioneering effort of the university and how sport for social action can be expanded to further promote peace and development.
Influência do uso do tabaco em população com múltiplas condições crônicas

O tabagismo representa um fator de risco para o desenvolvimento de complicacoes de doencas cronicas nao transmissiveis, sendo classificado como uma delas e potencializador de outras condicoes semelhantes. Abordar tabagismo e intervencao custo-efetivo, em todos os niveis de atencao, prevenindo agravos, reduzindo tanto complicacoes quanto mortalidade cardiovascular e global. Para a populacao de alto risco cardiovascular (especialmente hipertensa, diabetica e com doenca renal cronica), com comorbidades presentes, parar de fumar pode ser a melhor intervencao a ser realizada. Em todas as intervencoes que visem ampliar o alcance da cessacao do tabaco, deve-se entender melhor o perfil dos fumantes de forma detalhada, e assim, tracar de forma efetiva, planos estrategicos para atencao individualizada e melhores resultados. Objetivos: Em usuarios com multiplas condicoes cronicas de alto e muito alto risco cardiovascular, identificar, conforme o uso do tabaco: 1. O perfil psicossocial, indicadores clinicos, metabolicos e comorbidades associadas; 2. As associacoes deste perfil de acordo com o uso do tabaco; 3. Avaliar temporalmente, num seguimento de 12 meses, indicadores clinicos (especialmente desfechos cardiovasculares e progressao da doenca renal), segundo o uso do tabaco. Metodos: Estudo transversal, realizado no Centro HIPERDIA Minas Juiz de Fora, Brasil, que administra os pacientes com alto risco cardiovascular, hipertensao arterial, diabetes mellitus e doenca renal cronica. Resultados: Dos 1558 participantes, 12% eram fumantes; 41% ex-fumantes e 47% nunca fumaram. Na analise univariada, tabagismo atual foi associado com sexo, idade, atividade fisica, consumo de alcool, sintomas depressivos, excesso de peso, e aterosclerose. Nas analises multinomiais, varias doencas cronicas foram associadas com o uso atual ou anterior do tabaco; doenca pulmonar obstrutiva conica e doenca aterosclerotica foram mais prevalentes entre os pacientes que eram fumantes. Nao houve diferencas estatisticas significativas na avaliacao longitudinal de desfechos clinicos ou velocidade da filtracao glomerular, segundo o uso do tabaco. Conclusao: O tabagismo foi tao prevalente na populacao estudada quanto na populacao geral. Fumantes apresentavam pior perfil clinico comparado aos exfumantes ou aos que nunca fumaram. O apoio a cessacao do tabagismo pode render beneficios consideraveis, aliado a reducao de custos de cuidados com a saude, especialmente, em populacao com multiplas condicoes cronicas de alto risco cardiovascular.
Visual loss from mismanaged ocular injury with foreign body impaction: A Case Report

Ocular injury occurs commonly and it may lead to visual impairment if it is not properly managed. We report the case of a 35-year old man with a retained infected ocular foreign body in his right eye following an injury. The foreign body was not discovered despite consulting non-ophthalmologists at a Maternity Centre and an Optical Shop over a period of ten days. At presentation at the Specialist Hospital, he was unable to see with swelling of the eyelid, red eye and discharge. On examination, the visual acuity in the affected eye was NLP and an infected stick that penetrated the eyeball was discovered in the superonasal aspect of sclera covered by the swollen upper lid. This resulted in endophthalmitis, cataract and blindness of that eye. Ocular injuries must be promptly referred to the ophthalmologist for appropriate care and to prevent complications. The case clearly showed a diagnostic and therapeutic challenge for paramedics who encounter eye injuries outside the tertiary hospital setting. Therefore, this report raises public health concern intended to increase awareness on the management of eye injuries. The incorporation of Primary Eye Health into Primary Health Care along with training and re-training of Community Health Extension Workers, General Practitioners and other rural health workers cannot be overemphasized.
Developing glutathione transferase M2-derived peptides as specific inhibitors to treat RyR2-based cardiac disorders

Release of Ca from the sarcoplasmic reticulum (SR) through the cardiac ryanodine receptor (RyR2) is an essential step in cardiac excitation–contraction coupling. Excess Ca release due to overactive RyR2 can cause arrhythmia that can lead to cardiac arrest. Fragments derived from the carboxy-terminal domain of human glutathione transferase M2 (GSTM2C) specifically inhibit RyR2 activity. Our aim was to further improve this inhibition by mutagenesis and to assess the therapeutic potential of GSTM2C based peptides to treat Ca release-based arrhythmia. We generated several mutant variants of the C-terminal fragment GSTM2C H5-8 and from those mutant proteins we identified two (RM13 and SM2) that exhibited significantly greater inhibition of cardiac SR Ca release and single RyR2 channel activity. Flow cytometry analysis showed that these two mutant proteins as well as GSTM2C H5-8 are taken up by isolated adult mouse cardiomyocytes without the aid of any additional compounds, Ca imaging and isolated cell contraction measurements revealed that GSTM2C H5-8, SM2 and RM13 reduce the SR Ca release rate and the fractional shortening of adult mouse cardiomyocytes, while importantly increasing the rate of Ca removal from the sarcoplasm. These observations indicate that peptides derived from GSTM2C inhibit RyR2 at a cellular level and thus they may provide the basis for a novel therapeutic agent to treat arrhythmia and heart attack. ã 2015 Elsevier Inc. All rights reserved.
La Función Pragmática De Las Emisiones Dirigidas A Bebés. Un Estudio En Hogares De Distintos Grupos Socioeconómicos De Argentina

El trabajo analiza el habla dirigida por adultos a bebes en situaciones de interaccion espontaneas en hogares de distintos grupos socioeconomicos de Buenos Aires, Argentina. Desde una perspectiva pragmatica, diversas investigaciones han senalado la presencia de una mayor cantidad de directivas en el habla dirigida a ninos de nivel socioeconomico bajo (Hart & Risley, 1995; Mastin et al., 2016). En tanto estos estudios fueron realizadas en poblaciones que difieren social, cultural y linguisticamente de la poblacion de Argentina, la descripcion del entorno linguistico de distintos grupos socioeconomicos de este pais puede contribuir a dar cuenta del rango de variabilidad en las experiencias linguisticas infantiles. El corpus esta conformado por 20 horas audiograbadas de la vida cotidiana de 10 ninos de entre 8 y 16 meses de edad –cinco de poblaciones urbano marginadas y cinco de sectores medios. Los turnos de intervencion de los interlocutores de los ninos se clasificaron a partir de un sistema de categorias adaptado de Bloom (1970, cit. en Snow et al. 1976). Se distinguio entre directivas, preguntas, comentarios, reportes y rituales linguisticos. El analisis estadistico mostro diferencias significativas entre la cantidad relativa de directivas y comentarios en el habla dirigida a ninos de nivel socioeconomico bajo y nivel socioeconomico medio. Un posterior analisis cualitativo de estas dos funciones pragmaticas en el corpus puso de manifiesto las distintas formas que cada una de ellas adopta asi como tambien los recursos linguisticos que se emplean. Por ultimo, los resultados obtenidos se discuten contrastandolos con los de otras investigaciones.