Miracle-dz/UniFAR-FTUs huggingface dataset:
Sparse EEG Source Localization Using LAPPS: Least Absolute l-P (0

<italic>Objective:</italic> The electroencephalographic (EEG) inverse problem is ill-posed owing to the electromagnetism Helmholtz theorem and since there are fewer observations than the unknown variables. Apart from the strong background activities (ongoing EEG), evoked EEG is also inevitably contaminated by strong outliers caused by head movements or ocular movements during recordings. <italic>Methods:</italic> Considering the sparse activations during high cognitive processing, we propose a novel robust EEG source imaging algorithm, least absolute <inline-formula><tex-math notation="LaTeX">$l$</tex-math></inline-formula>-P (0<p<1) penalized solution (LAPPS), which employs the <inline-formula><tex-math notation="LaTeX">${l_1}$</tex-math></inline-formula>-loss for the residual error to alleviate the effect of outliers and another <inline-formula><tex-math notation="LaTeX">${l_p}$</tex-math></inline-formula>-penalty norm (p = 0.5) to obtain sparse sources while suppressing Gaussian noise in EEG recordings. The resulting optimization problem is solved using a modified alternating direction method of multipliers algorithm. <italic>Results:</italic> Simulation study was performed to recover sparse signals of randomly selected sources using LAPPS and various methods commonly used for EEG source imaging including weighted minimum norm estimate, <inline-formula><tex-math notation="LaTeX">${l_1}$</tex-math></inline-formula>-norm, standardized low resolution electromagnetic tomography and focal underdetermined system solver solution. The simulation comparison quantitatively demonstrates that LAPPS obtained the best performances in all the conducted simulations for various dipoles configurations under various signal-to-noise ratio on a realistic head model. Moreover, in the localization of brain neural generators in a real visual oddball experiment, LAPPS obtained sparse activations consistent with previous findings revealed by EEG and functional magnetic resonance imaging. <italic>Conclusion:</italic> This study demonstrates a potentially useful sparse method for EEG source imaging, creating a platform for investigating the brain neural generators. <italic>Significance:</italic> This method alleviates the effect of noise and recovers sparse sources while maintaining a low computational complexity due to the cheap matrix-vector multiplication.
Two-Layered Susceptibility Vessel Sign and High Overestimation Ratio on MRI Are Predictive of Cardioembolic Stroke

Two characteristics of the susceptibility vessel sign, overestimation ratio (overR), a quantitative evaluation of the susceptibility vessel sign, and the 2-layered susceptibility vessel sign (TL-SVS), were reported to predict cardioembolic stroke. These 2 biomarkers, on 1.5T or 3T systems (159 and 101 patients, respectively), demonstrated high specificity (0.77 at 1.5T and 1 at 3T) and their simultaneous presence is highly associated with cardioembolism. SUMMARY: In a prospective study among patients in the THRombectomie des Artères Cerebrales trial, we analyzed the diagnostic accuracy of 2 imaging biomarkers, the 2-layered susceptibility vessel sign and a high overestimation ratio, obtained on pretreatment brain T2* sequences, to identify cardioembolic stroke etiology (107/260 patients). In combination, these 2 biomarkers, on 1.5T or 3T systems (159 and 101 patients, respectively), demonstrated high specificity (0.77 at 1.5T and 1 at 3T) and their simultaneous presence is highly associated with cardioembolism.
Protective Effects of Five Structurally Diverse Flavonoid Subgroups against Chronic Alcohol-Induced Hepatic Damage in a Mouse Model

Alcoholic liver disease (ALD) has become one of the major global health problems, with augmented morbidity and mortality. Evidence indicates that flavonoids can reduce the risk of ALD owing to their biological properties. However, the effect of structurally different flavonoid subclasses on alleviating alcohol-induced liver damage in a same model has never been studied. In this study, mice were supplemented with five kinds of flavonoid subgroups, apigenin (flavone), quercetin (flavonol), naringenin (flavanone), (-)-epigallocatechin gallate (flavanol), and genistein (isoflavone), in the same dose (0.3 mmol kg−1 body weight) and then given 50% alcohol by gastric perfusion for five consecutive weeks. The results demonstrated that genistein and naringenin had greater benefits in terms of mitigating fibrosis and apoptosis, respectively, in the liver. Lipid deposition, partial inflammatory-related factors (nuclear factor kappa B p65, cyclooxygenase-2, and interleukin-6 levels), and hepatic histopathological alterations were similarly attenuated by five kinds of flavonoids. All the flavonoids also showed different degrees of influence on protecting against alcoholic liver injury on other aspects, such as serum biochemistry makers, hepatic lipid accumulation, lipid peroxidation, antioxidant capacities, and inflammation.
Chemistry and Pharmacology of Tinospora cordifolia

Tinospora cordifolia (Menispermaceae) is an Ayurvedic medicinal plant distributed throughout the Indian subcontinent and China. The whole plant is used in folk and the Ayurvedic system of medicine alone and in combination with other plants. Due to its commercial importance, T. cordifolia has been of intense research interest for the last four decades with the isolation of diverse compounds such as alkaloids, sesquiterpenoids, diterpenoids, phenolics, steroids, aliphatic compounds and polysaccharides, along with the discovery of a wide spectrum of pharmacological properties like immunomodulation, anticancer, hepatoprotective and hypoglycemic. Although pharmacological activities of extracts and compounds of T. cordifolia have been studied both in vitro and in vivo, only few mechanisms of action have been explored and need further elaboration. In the present review, the pharmacological activities of compounds and different extracts of T. cordifolia are highlighted, along with those of the marketed products, showing the relevance of phytochemicals and the standardization of the marketed products for medicinal use. This compilation of the extensive literature of T. cordifolia here will be a referral point for clinical study and the development of standardized phytomedicines in healthcare.
Evaluation of Intravenous Parecoxib Infusion Pump of Patient-Controlled Analgesia Compared to Fentanyl for Postoperative Pain Management in Laparoscopic Liver Resection

Background As laparoscopic liver resection is becoming a commonly used method for hepatic surgery, postoperative pain management is emerging as one of the trickiest problems after surgery. The ideal method of pain management is controversial and the optimal strategy for postoperative pain management after surgery remains unclear. The present study evaluated the postoperative analgesic efficacy of parecoxib and fentanyl, and the benefit of a new intravenous parecoxib infusion pump with patient-controlled analgesia after laparoscopic liver resection. Material/Methods This controlled, prospective, randomized, double-blind trial compared VAS scores among 3 groups of patients: a fentanyl group (FEN group) using a fentanyl citrate pump, an intravenous parecoxib group (IVPA group) receiving intravenous parecoxib, and a parecoxib pump group (PUPA group) receiving parecoxib sodium by analgesia pump. We enrolled 124 patients planned for laparoscopic liver resection. The primary outcome was VAS score at rest and with movement. Secondary outcomes were adverse effects (including nausea), sedation, pruritus, and quality of life. Result For all time intervals, the VAS scores were significantly lower in the PUPA group. VAS scores at rest and with movement in the PUPA group were the lowest among the 3 groups, while the scores in the FEN group were the highest. More adverse effects were detected in the FEN group, and no significant differences in adverse effects were found between the intravenous group and the parecoxib pump group. Conclusions Use of the intravenous infusion parecoxib pump for patient-controlled analgesia provides superior analgesic efficacy and fewer adverse effects for patients after laparoscopic liver resection.
Leadership and Project Success in Development Sector

Aim/purpose – The study aims to investigate the relationship among the leadership, operational efficiency and project success in general and the impact of transformational leadership and operational efficiency on project success in particular. Design/methodology/approach – Mean comparison from descriptive statistics and multiple linear regression from inferential statistics was used to determine the association between variables and further impact of the transformational leadership and operational efficiency on project success in the development sector. The paper presents the results of a survey conducted among 200 employees from the top, middle & lower management levels of various national & international development organizations working in Pakistan like Microfinance Banks and other Rural Support Programs. Statistical Package for Social Sciences (SPSS) was used to process data. Findings – The result shows positive association among transformational leadership, operational efficiency and project success. In addition, it was found that transformational leadership and operational efficiency have a positive and statistically significant impact on the project success. It is concluded that both transformational leadership and operational efficiency are vital to achieving the optimum level of success in any project, especially in the development sector. Research implications/limitations – The integral limitation of the study was the respondents because most of the development organizations have their operations in rural areas where access was difficult because of limited time and resources. In addition, such organizations are always reluctant to provide survey feedback. Originality/value/contribution – The paper contribution is in the theoretical and practical knowledge of the project success factors in the development sector which is Saghir Ahmed, Abdullahi M. Abdullahi 6 still a somehow unexplored area. Regulators of the development sector may be benefited from this study.
NeuroImage: Clinical Can we use neuroimaging data to di ﬀ erentiate between subgroups of children with ADHD symptoms: A proof of concept study using latent class analysis of brain activity

Background: Multiple pathway models of ADHD suggest that multiple, separ- able biological pathways may lead to symptoms of the disorder. If this is the case, it should be possible to identify subgroups of children with ADHD based on distinct patterns of brain activity. Previous studies have used latent class analysis (LCA) to de ﬁ ne subgroups at the behavioral and cognitive level and to then test whether they di ﬀ er at the neurobiological level. In this proof of concept study, we took a reverse approach. We applied LCA to functional imaging data from two previously published studies to explore whether we could identify subgroups of children with ADHD symptoms at the neurobiological level with a meaningful relation to behavior or neuropsychology. Methods: Fifty-six children with symptoms of ADHD (27 children with ADHD and 29 children with ASD and ADHD symptoms) and 31 typically developing children performed two neuropsychological tasks assessing reward sensitivity and temporal expectancy during functional magnetic resonance imaging. LCA was used to identify subgroups with similar patterns of brain activity separately for children with ADHD-symptoms and typically developing children. Behavioral and neu- ropsychological di ﬀ erences between subgroups were subsequently investigated. Results: For typically developing children, a one-subgroup model gave the most parsimonious ﬁ t, whereas for children with ADHD-symptoms a two-subgroup model best ﬁ ts the data. The ﬁ rst ADHD subgroup ( n =49) showed attenuated brain activity compared to the second subgroup ( n =7) and to typically developing children ( n =31). Notably, the ADHD subgroup with attenuated brain activity showed less behavioral problems in everyday life. Conclusions: In this proof of concept study, we showed that we could identify distinct subgroups of children with ADHD-symptoms based on their brain activity pro ﬁ les. Generalizability was limited due to the small sample size, but ultimately such neurobiological pro ﬁ les could improve insight in individual prognosis and treatment options. cues with unexpected timing. We studied brain activity di ﬀ erences between these expected and unexpected events. In addition, we used
A time to fast

Nutrient composition and caloric intake have traditionally been used to devise optimized diets for various phases of life. Adjustment of meal size and frequency have emerged as powerful tools to ameliorate and postpone the onset of disease and delay aging, whereas periods of fasting, with or without reduced energy intake, can have profound health benefits. The underlying physiological processes involve periodic shifts of metabolic fuel sources, promotion of repair mechanisms, and the optimization of energy utilization for cellular and organismal health. Future research endeavors should be directed to the integration of a balanced nutritious diet with controlled meal size and patterns and periods of fasting to develop better strategies to prevent, postpone, and treat the socioeconomical burden of chronic diseases associated with aging.
Unpacking (the) secret: Anonymous social media and the impossibility of networked anonymity

This study focuses on the perceptions and practices of anonymous communication with friends enabled by tie-based anonymous apps. Based on qualitative analysis of in-depth interviews with users of the application Secret, the strategies deployed by interviewees in order to de-anonymize other users are emphasized and placed within the broader context of the real-name web. The article shows that Secret was not only based on pre-existing social networks but also drew on the network as a structure of thought. The concept of networked anonymity is introduced to account for the ways that anonymous actors imagine one another as “someone,” rather than as an unknown “anyone. ” As such, the survivability of this communicative model is inherently limited by competing forces—the drive to connectivity, on the one hand, and to anonymity, on the other.
A Review on Flexible and Transparent Energy Storage System

Due to the broad application prospect, flexible and transparent electronic device has been widely used in portable wearable devices, energy storage smart window and other fields, which owns many advantages such as portable, foldable, small-quality, low-cost, good transparency, high performance and so on. All these electronic devices are inseparable from the support of energy storage device. Energy storage device, like lithium-ion battery and super capacitor, also require strict flexibility and transparency as the energy supply equipment of electronic devices. Here, we demonstrate the development and applications of flexible and transparent lithium-ion battery and super capacitor. In particular, carbon nanomaterials are widely used in flexible and transparent electronic device, due to their excellent optical and electrical properties and good mechanical properties. For example, carbon nanotubes with high electrical conductivity and low density have been widely reported by researchers. Otherwise, graphene as an emerging two-dimensional material with electrical conductivity and carrier mobility attracts comparatively more attention than that of other carbon nanomaterials. Substantial effort has been put on the research for graphene-based energy storage system by researchers from all over the world. But, there is still a long way to accomplish this goal of improving the performance for stretchable and transparent electronic device due to the existing technical conditions.
Group Therapy for Patients with Adjustment Disorder in Primary Care

Abstract A high percentage of patients have a diagnosis of adjustment disorder (AD) when they arrive at primary care (PC) appointments. However, most of them do not receive adequate psychological treatment. The present study’s aim is to determine the efficacy of a group psychological treatment program in patients with AD. The sample consisted of patients with AD from two PC units in Valencia, from which two groups were randomly generated: A treatment group (n = 31) and a waiting-list group (n = 20), homogeneous in terms of socio-demographic and psychometric variables prior to treatment. Treatment consisted of eight one-hour group sessions held on a weekly basis; taking a cognitive-behavioral approach, they addressed aspects like controlling anxiety, cognitive restructuring, and coping techniques. The variables analyzed were: Psychopathology (Revised Symptom Inventory, SCL–90–R), health-related quality of life (Health Questionnaire, SF–12), and risk of suicidal behavior (Suicide Risk Scale). Means comparisons, ANCOVAs, and tests of effect size were performed. Statistically significant differences were observed in the variables, such that after intervention, the experimental group exhibited less anxious (F = 4.11, p =.048, η2 = .08) and depressive symptoms (F = 2.41, p =.029, η 2= .10) and higher quality of life related to physical (F = 7.17, p =.010, η2 = .13) and emotional health (F = 10.31, p =.002, η2 = .18). For the reasons above, we conclude that a comprehensive approach to emotional distress in PC, including group psychological interventions, is one solution for the demand for social services, and could provide savings on economic as well as human costs.
Level of mother-baby bonding and influencing factors during pregnancy and postpartum period.

BACKGROUND Bonding is the process of an emotional relationship between mothers and babies. Pregnancy and postpartum periods are most important of developing a mother-child bonding. Here we aimed to determine the level of mother-baby bonding and identify the influencing factors during pregnancy and the postpartum period and to examine the relationship between bonding level during pregnancy and the postpartum period. SUBJECTS AND METHODS This cross-sectional descriptive study included twelve districts across a range of socioeconomic structures. Every district was selected by a simple random sampling method. Data were collected with Prenatal Attachment Inventory, Mother-to-Infant Bonding Scale, Center for Epidemiologic Studies' Depression Scale and Beck Anxiety Inventory. The study included two home visits. The first visit at gestational age ≥35 weeks and second visit on the seventh or eighth day of the postpartum period. The study was conducted with 227 pregnant women. RESULTS We found that, 50.7% pregnant women had prenatal depression and 36.6% pregnant women had postpartum depression. We detected a negative association between depression level during pregnancy and the postpartum period with mother-baby bonding in the postpartum period (r=0.174, p=0.009; and r=0.221, p=0.001, respectively). A negative correlation was detected between anxiety level and mother-baby bonding level in the postpartum period (r=0.151, p=0.023). It was found that when the prenatal attachment level increases, the level of postpartum bonding is also increases (r=0.297, p=0.000). CONCLUSIONS Depression and anxiety levels were higher during pregnancy than the postpartum period. Depression level during pregnancy and postpartum period depression and anxiety level negatively affected mother-baby bonding in the postpartum period. We found that as prenatal attachment level increases, the level of postpartum bonding also increases.
The hidden side of news diffusion: Understanding online news sharing as an interpersonal behavior

Unlike previous approaches to online news sharing behaviors dealing with the dissemination of information to broader audiences, this article interprets that behavior as an act of relational communication. Drawing from surveys of 400 online news users, we examine how they manage their self-presentation and account for their audience’s characteristics differently when they engage in online news sharing activities on mobile instant messenger (MIM) and social networking site (SNS). Our findings suggest that individuals who are highly motivated by self-presentation share news online more than others. Individuals also target different audiences, depending on their media environments. Specifically, SNS users are more cautious about their audiences’ connections with other users. The implications are that news sharing behaviors are a type of communication used for forming relationships and managing impressions beyond informational purposes, based on active individuals’ strategic considerations of their audiences’ characteristics.
Cognitive stimulation therapy for brazilian people with dementia: examination of implementation’ issues and cultural adaptation

Abstract Objectives: The prevalence of dementia has been increasing particularly in developing countries. However, people with dementia (PwD) in Brazil are currently offered no psychosocial treatment upon diagnosis. Cognitive stimulation therapy (CST) that originated in the UK has proven benefits on cognition and quality of life in PwD. We investigate the possible issues for the implementation of CST for the Brazilian population and its cultural appropriateness. Method: Individual interviews and focus groups were conducted with PwD, their caregivers and health professionals (n = 37). Data were recorded and transcribed, before being analyzed using Framework Analysis. Results: Regarding the issues for implementation of CST in the Brazilian population, two main themes emerged, ‘Barriers’ and ‘Facilitators’, along with nine subthemes. Overall, the activities and materials were seen as being appropriate for use with the Brazilian population, some minor changes were suggested. Conclusions: The results indicate that CST is appropriate for use in the Brazilian population, only some cultural adaptations are necessary. In the stakeholders’ opinions, CTS intervention is needed in Brazil, due to the lack of treatment options for PwD in developing countries.
The effects of education and clinical specialization on nurses’ status affirmation by physicians: A quantitative analysis

ABSTRACT Research has demonstrated a status gap between members of healthcare delivery teams. However, it is unclear which factors mitigate or exacerbate the status gap between healthcare providers. This paper examines the concept of status affirmation, the belief that others affirm the individual’s social standing, as one factor that can affect the status gap between healthcare professionals. The aim of this exploratory study was to investigate two factors that affect nurses’ status affirmation: nurses’ educational backgrounds and clinical specializations. A close-ended survey was administered to registered nurses in Indiana, a midwestern American state1 (N = 1262) to identify which nurses are likely to have their status affirmed by physicians, in general. Results of multinomial logistic regression analyses suggest that highly educated nurses are unlikely to receive status affirmation, and there are differences in status affirmation across clinical specialties. In addition, nurses with advanced degrees often do not work in specialties that receive status affirmation. These results suggest that conflict among nurses and doctors is as likely to exist across divisions in nurses’ educational attainment as across work specializations. Status affirmation is posited as a theoretical antecedent to interprofessional collaboration.