Miracle-dz/UniFAR-FTUs huggingface dataset:
Study of the efficiency in the prescription of antihypertensive agents based on efficacy according to the atom study results

Background/Aim The hypertension is the persistent elevation of SBP ≥ 140 and/or DBP ≥ 90 mmHg. It is the most common condition seen in primary care, approximately 7% of the outpatient visits are due to hypertension. On average, a hypertensive patient would cost twice that of a normotensive individual, because hypertension is a risk factor for other diseases. The aim of the study is to calculate the cost-effectiveness of the reduction and control of hypertension using antihypertensive active ingredients. There are only few studies comparing the efficacy and/or effectiveness of the most commonly used antihypertensive drugs. Materials and methods This study is based mainly in the Atom study, a systematic review of clinical trials followed by a meta-regression. A cost-effectiveness study has been completed through the application of the concept of Law et al. and by the ICER analysis. Results This work compares the effectiveness and cost-effectiveness of different antihypertensive drugs commonly used in clinical practice. According to the data analysed, the most cost-effectiveness treatments are (depending on the blood pressure reduction interval): Enalapril 10, Amlodipine 5, Enalapril 20 + Amlodipine 5, Bisoprolol 5, Enalapril 20 + Indapamide 1.25, Enalapril 20 + HCTZ 12.5, Olmesartan 40 + Amlodipine 10 + HCTZ 25 and Enalapril 20 + HCTZ 12.5 + Amlodipine 10. Also, it has been proven that the results of the study are in agreement with the antihypertensive treatments prescribed in the current clinical practice in the sanitary region of Girona. Conclusions The effectiveness analysis and the pharmacoeconomic study provide new information about antihypertensive active ingredients, with the objective of being able to apply it in the usual clinical practice. This knowledge would potentially help the clinician to choose the most adequate treatment and improve the health of patients
Response to referee_1

We compare the atmospheric column-averaged dry-air mole fractions of carbon dioxide (XCO2) and methane (XCH4) measured with a pair of Collaborative Carbon Column Observing Network (COCCON) spectrometers at Kiruna and Sodankylä sites in boreal areas with model data provided by the Copernicus Atmosphere Monitoring Service (CAMS) between 2017 and 2019 and with XCH4 from the recently launched Sentinel-5 Precursor (S5P) satellite between 2018 and 2019. In addition, 20 measured and modeled gradients of XCO2 and XCH4 (ΔXCO2 and ΔXCH4) on regional scales are investigated. Both sites show a similar and very good correlation between COCCON retrievals and the modeled CAMS XCO2 data, while CAMS data are biased high with respect to COCCON by 3.72 ppm (±1.80 ppm) in Kiruna and 3.46 ppm (±1.73 ppm) in Sodankylä on average. For XCH4 CAMS values are higher than the COCCON observations by 0.33 ppb (±11.93 ppb) in Kiruna, and 7.39 ppb (±10.92 ppb) in Sodankylä. In contrast, the S5P satellite generally measures lower atmospheric XCH4 than the COCCON 25 spectrometers, with a mean difference of 9.69 ppb (±20.51 ppb) in Kiruna and 3.36 ppb (±17.05 ppb) in Sodankylä. We compare the gradients of XCO2 and XCH4 (ΔXCO2 and ΔXCH4) between Kiruna and Sodankylä derived from CAMS analysis and COCCON and S5P measurements to study the capability of detecting sources and sinks on regional scales. The correlations in ΔXCO2 and ΔXCH4 between the different datasets are generally smaller than the correlations in XCO2 and XCH4 between the datasets at either site. The ΔXCO2 predicted by CAMS are generally higher than those observed with COCCON with a 30 slope of 0.51. The ΔXCH4 predicted by CAMS is mostly higher than that observed with COCCON with a slope of 0.65, covering a larger dataset than the comparison between S5P and COCCON. When comparing CAMS ΔXCH4 with COCCON ΔXCH4 only in S5P overpass days (slope = 0.53), the correlation is close to that between S5P and COCCON (slope = 0.51).
TIME-DOMAIN ANALYSIS OF OVERHEAD LINE IN PRESENCE OF STRATIFIED EARTH

The presence of the ground affects the propagation on overhead lines through a magnetically induced earth return current. Numerous researches have been conducted to study this influence by considering a homogeneous earth. In the current paper, the transient response of Multi-conductor transmission Lines (MTL) considering a lossy stratified earth is presented. Based on the finite difference time-domain (FDTD) and an improvement of the convolution integral arising from timedomain modeling of frequency-dependent conductors’ parameters through the Vector Fitting (VF) algorithm, a novel numerical procedure for solution of a system of telegraph equations is presented. Many simulations are introduced to highlight the effect of soil stratification on the response of the line for a given excitation. The efficiency of an equivalent model, using an equivalent single-conductor, of a multiple conductor system is also established in this work.
Assessing bank lending to corporates in the euro area since 2014

Bank lending to euro area corporates has gradually recovered since 2014, supported by very favourable financing conditions. An assessment of this recovery indicates that it has been broadly in line with economic activity, although loan growth has remained below pre-crisis levels. The moderate pace of the recovery in loan growth mainly reflects the post-crisis deleveraging process and the growing relevance of alternative sources of financing, as well as somewhat weaker economic activity compared with the pre-crisis period. Nevertheless, evidence suggests that bank lending to non-financial corporations has supported firms’ business investment. The strength of the relationship between business investment and bank lending to corporates has, however, differed across euro area countries. Qualitative and quantitative evidence shows that the recovery in bank lending to corporates has received strong support from the ECB’s non-standard monetary policy measures. JEL Classification: E4, E44, E5, E52
Productive and reproductive performances of indigenous chicken population and traits preference of smallholder farmers in Bale Zone, Oromia Regional State, Ethiopia

A study was conducted on productive and reproductive performances of indigenous chicken population and traits preference of smallholder farmers in Bale Zone, Oromia Regional State, Ethiopia for assessing productive and reproductive performances of indigenous chicken population and farmers traits preference in study area. The study was conducted in five selected districts (Madda Walabu, Delomena, Berbere, Ginnir and Sinana districts) of Bale zone, south east Ethiopia. For this study, a total of 390 household having indigenous chicken population were sampled using simple random sampling techniques. The collected data were coded and inserted on Microsoft excel spread sheet and analysed using SAS software version 9.13. Growth rate and egg production traits are the first and second selection criteria preferred by farmers/pastoralists across study districts. Weight is the main trait preference by farmers/pastoralist both for male and female chicken across all study districts. The average age of indigenous cockerels and pullets at first mating and laying was 4.30 ± 0.1 and 4.50 ± 0.1 months, respectively. The number of clutches per hen and eggs per clutch and total eggs produced per hen per year were 4.0 ± 0.12, and 20.18 ± 0.66 eggs, respectively. The hatchability and survival rate of chicks were 76.25 and 74.35%, respectively. The result of study indicated that farmers/pastoralists in study area were practices different selection criteria and trait preference both for male and female chicken. Therefore, the study suggested that there is an opportunity for genetic improvement through selection and there is a need of in-depth breed characterization and the relationship of trait preference of farmers/pastoralists with economical values of the traits.
Electromagnetic Machine Learning for Inverse Modeling Using the Spatial Singularity Expansion Method

In this article, we propose a general technique that utilizes a unified electromagnetic and machine learning (ML) technique for inverse modeling and antenna characterization. The recently developed spatial singularity expansion method (S-SEM) is deployed to explicate the electromagnetic behavior of antennas in the form of an accurate digital signal processing (DSP) model. An ML framework is devised and combined with the S-SEM-based DSP model to design a novel inverse source modeling algorithm. The combined S-SEM-ML system departs from the state-of-the-art approaches in being capable of processing far-field data in order to jointly estimate the surface current distribution on the examined radiators, in addition to reconstructing their geometrical details. Various straight and bent wire systems are investigated, including single and multiple array configurations. A study on the impact of additive free-space noise on the estimation process is also presented. Finally, a measurement apparatus is provided to validate the proposed S-SEM-ML system.
Defect proliferation in CsPbBr3 crystal induced by ion migration

Ion migration in halide perovskite materials usually brings an intractable problem in the working stability of solar cells and photoelectrical detectors. The mechanism of ion migration and its impact on physical properties are still open questions. In this work, the ion migration behavior in solution-grown CsPbBr3 crystals was observed by the hysteresis in current–voltage curves and the temperature dependent reversed current–time measurements. Defect proliferation phenomena (new defects of [VCs]− and [PbBr]2+) originating from ion migration were verified by thermally stimulated current spectroscopy. Our results also give evidence that Cs+ ions also participate in the process of ion migration except the widely considered Br− ions. Furthermore, the photoelectric properties of the CsPbBr3 device were found to be seriously deteriorated after the ion migration. Our work demonstrates the strong correlation between the ion migration and physical properties in halide perovskites.
NO EVIDENCIA DE Mycobacterium tuberculosis EN CANINOS QUE CONVIVEN CON PACIENTES CON TUBERCULOSIS PULMONAR NO EVIDENCE OF MYCOBACTERIUM TUBERCULOSIS IN D OGS LIVING WITH PULMONARY TUBERCULOSIS PATIENTS

Tuberculosis (TB) is an infectious disease primarily of humans which produces high morbidity and mortality. Dogs are also susceptible to Mycobacterium tuberculosis infections; therefore, the present study searched for evidence of the presence of this pathogen in 58 dogs that live with human pulmonary TB patients in Lima, Peru. Chest Xray was performed and pharyngeal swab, saliva, bronchial fluid, urine and feces samples were taken from dogs. Fluorescence microscopy was performed with auramine O staining and TB culture by the Lowenstein Jensen and the Microscopic Observation Drug Susceptibility (MODS) methods. Epidemiological data was collected to define the patient
Antimicrobial prophylaxis for prevention of surgical infection

Surgical site infection is one of the most common healthcare-associated infection in which a wound infection occurs after an invasive (surgical) procedure. Method: This review provides practical recommendations and basic principles involved in the use of prophylactic antibiotic such as antibiotic dosing, the optimal time for administration of preoperative doses, best administration route, prophylaxis duration, need for intraoperative redosing and auditory process to evaluate the program adherence for optimizing the use of antibiotics. Results: The prophylactic antimicrobial agent should be administered at such a time to provide serum and tissue concentrations exceeding the minimum inhibitory concentration for the probable organisms associated with the procedure. The optimal time for administration of preoperative doses is within 30 or 60 minutes before surgical incision, except the agents with long elimination half-life whose administration should begin within 60 or 120 minutes before it. Intraoperative redosing is needed if the duration of the procedure exceeds two half-lives. The duration of antibiotic prophylaxis involves a single dose or continuation for 24 or 48 hours. Compliance of the antimicrobial guidelines should be measured to ensure protocol adherence. Conclusion: Optimal surgical prophylaxis administration should be considered a basic tool for prevention of surgical-site infections and related adverse effects
A Review on the Potential Role of Vitamin D and Mineral Metabolism on Chronic Fatigue Illnesses

The aim of this report is to review the effects of vitamin D-deficiency on chronic mineral deregulation and its clinical consequences. Recent research data are presented including the effects of vitamin D3-induced calcium sensing receptor (CaSR), fibroblast growth factor 23 (FGF23), the cofactor of FGF1-receptor α-klotho (αKl) and the interplay with each other and with vitamin D3-repressed parathormone (PTH). The importance of persistent calciumand phosphate deregulation following long-standing vitamin D3-deficiency for cellular functions and resistance to vitamin D3 treatment is discussed. It is proposed that chronic fatiguing illnesses might be result from mineral deregulations that are barely detected by routine laboratory workups because of compensatory changes in bone mineral stores.
The Impact of Measurement Noninvariance on Latent Change Score Modeling: A Monte Carlo Simulation Study

ABSTRACT Measurement invariance (MI) overtime is required for meaningful interpretation of changes in the latent change score model (LCSM). In this simulation study, we investigate the impact of measurement noninvariance on the estimation of LCSM when proportional change model, dual change model, and their bivariate versions are used with mean composites or MI-assumed measurement models. The results show that even noninvariance in one item could result in severe bias in the LCSM parameter estimates and false statistical inferences (e.g., Type I error). However, the impact depends on the simulation factors, fitted models, and estimated parameters. For example, the intercept-factor mean is biased in proportional change model but not in dual change model. In bivariate LCSM the parameter estimates of only the noninvariant variable are biased except coupling effects. Model fit indices such as RMSEA and SRMR are insensitive to the ignored noninvariance. Discussions and implications of findings are presented.
Small sided games: a scoping review of literature 2006-2016

This article reports the findings of a scoping review of the use of small-sided games (SSGs) as a teaching or coaching pedagogy across four game categories. The selection criteria included empirical research available online, published after January 1 2006 and prior to December 31, 2016, in an academic journal. The data were analysed through an inductive thematic approach which generated two themes: Development and Practical considerations. This review found that SSGs can be used as a deliberate pedagogy to elicit physiological responses for a training effect. Given that the variables associated with SSGs include pitch size, game intensity, and number of players, a key determining factor in the implementation of SSGs includes the objective of the practice activity.
Event-triggered communication scheme for stochastic systems in wireless sensor networks

With the development of sensors and network technology, wireless sensor networks are widely used in various scenes. However, in most applications, the energy of the sensor nodes cannot be supplemented. In addition, since the lifetime of the electronic switching element is measured by the number of trigger times, which makes the effective use of energy, extending the working life of the network becomes one of the key factors to be considered. This paper discusses an event-triggered control scheme for stochastic systems. The mechanism determines when the controller sends control data in order to balance system performance and drive frequency. In this paper, the control scheme is deduced by a class of quadratic performance index function. Then, the formula of performance index is designed based on state feedback and output feedback, and the upper bound of performance index is deduced and the conditions in the theorem can be constructed by solving a set of linear matrix inequalities, which can be easily tested with linear matrix inequality algorithms. Finally, a numerical example is given to illustrate the results.
The effect of memantine on cognitive performance with amnestic mild cognitive impairment

Objective: Amnestic mild cognitive impairment (aMCI) refers to cognitive changes that occur during the period of normal cognitive decline and very early dementia. We aimed to assess the efficacy of memantine used for the treatment of patients with aMCI. Methods: All patients were diagnosed as having aMCI according to the Petersen criteria and were assigned to one of three groups. Group 1 comprised patients who received memantine following examination (n=23), group 2 included patients who did not receive memantine treatment following examination (n=22), and group 3 was constituted by healthy age-matched volunteers (n=20). Following the examinations, neuropsychiatric tests from the Turquoise Alzheimer"s Study Group database used in dementia polyclinics were performed. Results: The mean age of patients was 66±7.04 years in group 1, 65.3±6.20 years in group 2, and 57.6±5.40 years in group 3. The most noticeable improvements in group 1 were seen in the Mini-Mental State Exam, Wechsler memory scale subtests, Blessed Dementia Rating Scale, and the Boston Naming Test (p<0.05). Treatment with memantine was associated with an improvement in Geriatric Dementia Scale scores over the 24week study period. Conclusion: These results suggest that memantine treatment in patients with aMCI acts to enhance cognitive functioning compared with no treatment. These findings suggest the need for a larger randomized placebo-controlled trial.
Potensi Minyak Atsiri Serai Wangi (Cymbopogon nardus) sebagai Antiproliferasi Sel Kanker Payudara MCM-B2.

INDAH RACHMAWATI. Potency of Lemongrass Essential Oil (Cymbopogon nardus) as Antiproliferation of MCM-B2 Breast Cancer Cells. Supervised by HASIM and DIMAS ANDRIANTO. One type of cancer that’s the biggest cause of death is breast cancer. However, research related to the development of herbal treatments as an anticancer alternative needs to be done. This study aims to analyze the potential of lemongrass essential oils as antiproliferation of MCM-B2 breast cancer cells. Stages of this research include the distillation of essential oils, determination of the chemical components of essential oils with GC-MS, testing the toxicity of essential oils, and the antiproliferation activity against MCM-B2 breast cancer cells. The results of phytochemical screening showed that alkaloids and tryterpenoids were contained. The dominant compounds contained in lemongrass essential oils are geraniol, citral, and myrcene. The toxicity test resulted an LC50 value of 5.34 ppm. The essential oil was able to significantly reduce MCM-B2 cancer cell growth (p<0.05). The concentration of 3 ppm showed that the results were not significantly different from doxorubicin, and the concentration of 24 ppm had the highest inhibitory activity with an IC50 value of 5.38 ppm. Keyword: Antiproliferation, breast cancer, essential oil, lemongrass, MCMB2. Skripsi sebagai salah satu syarat untuk memperoleh gelar Sarjana Sains pada Departemen Biokimia POTENSI MINYAK ATSIRI SERAI WANGI (Cymbopogon nardus) SEBAGAI ANTIPROLIFERASI SEL KANKER PAYUDARA MCM-B2
An Overview of Coding Tools in AV1: the First Video Codec from the Alliance for Open Media

Abstract In 2018, the Alliance for Open Media (AOMedia) finalized its first video compression format AV1, which is jointly developed by the industry consortium of leading video technology companies. The main goal of AV1 is to provide an open source and royalty-free video coding format that substantially outperforms state-of-the-art codecs available on the market in compression efficiency while remaining practical decoding complexity as well as being optimized for hardware feasibility and scalability on modern devices. To give detailed insights into how the targeted performance and feasibility is realized, this paper provides a technical overview of key coding techniques in AV1. Besides, the coding performance gains are validated by video compression tests performed with the libaom AV1 encoder against the libvpx VP9 encoder. Preliminary comparison with two leading HEVC encoders, x265 and HM, and the reference software of VVC is also conducted on AOM's common test set and an open 4k set.
Improvements of Crop Production through Integrated Soil Fertility Management in Ethiopia

Agriculture plays a central role within the Ethiopian economy. In our country, concerning 85% of total population depends on agriculture and its product. This implies agriculture provides a good portion of national product growth. In spite of the importance of this sector, production and productivity area units restricted by varied biophysical, social and economic aspects. Soil fertility decline is one of the central issues that scale back Ethiopian agriculture and at last, it ends up in poverty and starvation. The main causes of those entrenched challenges are the land degradation showed in type of soil fertility decline, as introduced by varied hindrances as deforestation, overgrazing and through a consequence of wearing away, deposit, pollution, etc. Hence, the core objectives of this review are to evaluate the soil fertility status in Ethiopia, the sources of soil fertility decline and find improved resolutions to soil fertility in Ethiopia. As the physiological factors of the country are rugged with dynamical sorts of soils, preponderantly the upland wherever regarding 90% of the tillable land is concentrated, difficulties such as soil erosion, meager and incessant cultivation are the chief reasons of soil fertility loss. Thus, the application of combined soil fertility management approach with presence and mixture of manure, compost, crop rotation, soil protection practices provides improved production and saves the soil fertility standing to an improved level. The apply undertaken by the government of Ethiopia, is that the application of optimum rate of fertilizers, but it's not thriving as a results of various factors like amendment of agroecology, edaphic factors, the social and economic state of affairs of the farmer, repair to property combined soil fertility management to get high yield while not compromising the soil fertility position within the future, this can be broad and needed to be followed.