Miracle-dz/UniFAR-FTUs huggingface dataset:
Minimal requirements in defined media for improved growth of some radio-resistant pink tetracocci

Defined media permitting extensive growth of representative pink radio-resistant tetracocci (Micrococcus radiodurans, Micrococcus roseus, and Micrococcus radiophilus) and two controls (an ultraviolet-sensitive mutant of M. radiodurans and Micrococcus luteus) are described. Availability of Fe (especially Fe3+) proved essential for good growth, as evidenced by (i) favorable effects of hydroxamic acids, e.g., salicylhydroxamic acid, and (ii) the growth promotion by hemin when joined with elevated concentrations of Fe. Cobalamin (B12) and methionine were interchangeable as an absolute requirement for methionine not affected by B12. M. luteus required neither. Pink radio-resistant micrococci may form a coherent group. Some divergences among them might be attributable to the method for isolating them, which for ordinary bacteria would be mutagenic to the point of total lethality. The ecology of these tetracocci vis-à-vis other pink-red radio-resistant organisms is discussed in relation to a question: can these bacteria be isolated without dependence on radiation as the cardinal selective factor?
Dual Anticoagulation in Recurrent Thromboembolic Events with Failure of Monotherapy: A Novel Approach

In the last few decades many new anticoagulants (i.e direct thrombin and factor ten inhibitors) have been introduced with efficacy that rivals older drugs in the treatment of venous thromboembolism (VTE). However, for all their success, management of patients with recurrent thromboembolic events is still a challenging clinical scenario and not well addressed in the literature. We report the case of a young female with recurrent thromboembolisms in spite of using both newer agents and more conventional therapies. Ultimately, she is started on dual anticoagulation with warfarin and rivaroxaban without recurrence. This case report demonstrates that dual anticoagulants can be utilized in patients with recurrent VTE who fail single agent therapy. It also underscores the need for studies further elaborating on the utility of dual anticoagulants as a treatment modality for patients failing monotherapy.
Why the manufacturing sector still matters for growth and development in Indonesia

Is Indonesia's manufacturing sector still relevant for growth and development? As a result of the last boom in global commodity prices between 2003 and 2008, resources in Indonesia shifted towards commodities and resource-based manufacturing as these sectors seemed to promise higher returns on investment. In recent quarters, however, the manufacturing sector has exhibited stronger output growth rates and attracted more investment. This note argues that building on the current momentum of manufacturing growth is critical for Indonesia's development (i) to support the creation of higher-productivity jobs, (ii) to sustain higher economic growth and progress in structural change, and (iii) to achieve long-term prosperity. Finally, this note also shows how the Master Plan for the acceleration and expansion of Indonesia's economic development (MP3EI) acknowledges the importance of the manufacturing sector for economic growth.
Security in Prediction of Private Information on Social Network

Social networks are online applications that allow the users to connect by various links. The user can bring out the information of their friends in the networks and some are private information. This private information has higher possibilities to predict the private information from the user’s information using some learning algorithms. Both friendship links and details together gives better predictability than details alone. The usage of inference attacks are engaged to predict private information using the social networking data. Three refinement techniques are created which is used in various situations and the effectiveness of these techniques are explored. In the process, the results from the collective inference implications are combined with the individual results. It removes the details and friendship links together. It is the best way to reduce classifier accuracy. This method is probably infeasible in maintaining the use of social networks. However, removing the details only algorithm, greatly reduces the accuracy of local classifiers. Naive Bayes algorithm gives us the maximum accuracy that is able to achieve through any combination of classifiers. The objective is to reduce the classifier accuracy, while the details and the friendship links are removed together. Index Terms – Privacy definition, anonymization network, data mining, social network analysis.
Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

Summary Several actinomycin D (AD)-resistant sublines maintained at 0.1, 1.0, and 10.0 µg/ml AD and exhibiting an increase in resistance up to 2500-fold were developed in vitro from Chinese hamster cells. Dose-response data for sensitive and resistant sublines demonstrated that AD-resistant cells were cross-resistant, in decreasing order, to mithramycin, vinblastine, vincristine, puromycin, daunomycin, demecolcine, and mitomycin C. In general, the greater the cross-resistance to an agent, the greater its molecular weight. Increase in resistance to AD of a graded series of sublines was accompanied by proportional decrease in sensitivity to vincristine and daunomycin, and several experimentally derived daunomycin-resistant cell lines also exhibited increased resistance to AD. In radioautographic experiments, it was found that degree of resistance was inversely related both to degree of nuclear labeling by AD- 3 H and to inhibition of uridine-5- 3 H incorporation by the antibiotic. Karyotype analysis revealed that chromosomal alterations, once established, were stable and apparently were not specifically related to the resistant state. These investigations support the hypothesis that the development of resistance to AD in Chinese hamster cells is due to qualitative difference in cell membrane, resulting in decreased permeability to AD and other compounds.
[Activity of copper-zinc superoxide dismutase in a global ischemic brain lesion model without arterial hypotension].

OBJECTIVE To determine the behavior of the copper-zinc superoxide dismutase enzyme (SOD/Cu/Zn) in tissue homogenates of rat brains with ischemic lesions produced following the model of global cerebral ischemia without arterial hypotension. MATERIAL AND METHODS Thirty rats were randomly assigned to five groups of six animals each. Bilateral carotid occlusion was temporarily produced in 24 rats (4 groups) during periods of 5, 15, 30 and 60 minutes, respectively. All the animals were then submitted to reperfusion for 30 minutes and after that, they were sacrificed. A control group of 6 rats was not exposed to arterial occlusion. Cerebral homogenates of the rats' brain were obtained and submitted to spectrophotometer analysis. RESULT The control group showed the lowest mean values in SOD/Cu/Zn activity (40.60+/-11.42 U/mg of protein), while the highest mean values (60.34+/- 13.52 U/mg of protein) corresponded to the rats submitted to ischemia for 60 minutes, what indicates a statistically significant difference (p = 0.016) between the two groups. CONCLUSIONS SOD/Cu/Zn activity in rats increases during the production of ischemic cerebral lesions. The analysis of SOD/Cu/Zn activity showed an important tendency to rise from the 30 minutes period of ischemic lesion and reached statistically significant values at 60 minutes from the beginning of the ischemic injury. The experimental model of global brain ischemia without arterial hypotension used in this study constitutes a reliable method for researching cerebral ischemia.
Who Needs Physiologic Pacing and Why

Various pacing technologies have been developed during the past 50 years since the first pacemaker was implanted in 1958. Dual-chamber pacing, rate responsiveness, programmable and rate-responsive atrioventricular (AV) intervals, alternative-site pa0cing, and new multichamber pacing devices are all attempts to mimic normal cardiac physiology as much as feasible. The categories of alternative-site and multichamber pacing will not be addressed in this review. The term physiologic pacing refers to dual-chamber (DDD and DDDR) and atrium-based pacing (AAI and AAIR) in contrast to the ventricle-based mode of pacing (VVI and VVIR). Both AAI/R and DDD/R pacing preserve the synchrony of atrial and ventricular contraction, and therefore resemble the normal cardiac function more closely than does VVI/R pacing. Despite this physiological superiority of AAI and DDD pacing, VVI pacemakers are still used in a large proportion of patients with sick sinus syndrome. Physician’s reluctance toward implantation of more physiological pacemakers may be related to difficulties with implantation of an atrial lead, the higher device cost of DDD units, and the more complex programming and follow-up of such pacemakers. Moreover, the lack of large-scale prospective randomized trials to document which pacing mode is superior probably also contributes significantly.
Ki67 reactivity in cell membrane and cytoplasm of tonsil crypt epithelial cells.

To the Editors: The unexpected finding of selective but nonspecific reactivities of monoclonal antibodies has been the subject of several articles (1,2). Changes in epitope structure caused by fixation and the existence of short determinants shared by unrelated peptides and proteins have been pointed out, among others, as the possible sources of the anomalous reactions observed (1,3). In a recent article, Hirokawa and Carney (4) reported on the cell membrane and cytoplasmic reactivity for MIB-1, a wellknown Ki67 monoclonal antibody, in hyalinizing trabecular adenoma of the thyroid gland, emphasizing its value as a diagnostic tool in the differential diagnosis with papillary carcinoma. They also observed a faint reactivity in the apical surface of some normal follicular cells. Other normal tissues were not included in the study. Recently, we observed a similar immunoreactivity in squamous epithelial cells of the tonsil crypts, working with a different anti-Ki67 monoclonal antibody (Ki88; Biogenex, San Ramon, CA). With the introduction of this new clone in our laboratory, we performed a test battery to determine the optimal antibody dilution, and the best methods of antigen retrieval and immunodetection. To that end, we selected formalin-fixed, paraffinembedded tonsils currently used as controls for immunostaining of hematolymphoid (CD20, CD3, CD43, etc.) and proliferative markers (KiS5, MIB5). Several 5mthick sections were placed in a plastic container with citrate buffer (pH 6) and warmed in a water bath at 95°C to 99°C for 30 minutes. Ki88 monoclonal antibody (1/10–1/20) was incubated at room temperature for 1 hour. Two avidin-biotin-peroxidase methods (Super Sensitive, Biogenex, and Vectastain, Vector, Burlingame, CA) were used as detection systems, with DAB as chromogen. The results showed nuclear/nucleolar immunopositivity in germinal center cells of lymphoid follicles, as well as in basal epithelial cells of the superficial squamous lining (Fig. 1). Unexpectedly, many epithelial cells deep in the crypts forming a lymphocyte-containing mesh exhibited strong and delicate reactivity in the cell membranes and also in their cytoplasms (Fig. 2) No comparable staining was observed in the squamous superficial lining (Fig. 2) nor in other tissue components. Our findings support the view of Hirokawa and Carney that there is a nonrelated antigen restricted to some epithelial cells, probably containing epitopes of similar sequence (3,5), that crossreacts with Ki67 antibodies represented by MIB-1 in their article, and by Ki88 in the current study. This observation reminds us the CD79a crossreactivity in megakaryocytes produced by HM57 antibody, which has been recently evaluated as a marker for this cellular type in bone marrow biopsies (6). Other tissues should be tested for Ki67 immunopositivity to determine the real spectrum of this anomalous reactivity and its biologic significance.
What is the Value of Luxury? A Cross‐Cultural Consumer Perspective

International luxury businesses are challenged by the identification and satisfaction of the common needs and desires of global market segments. Although luxury goods have become available to a wider range of consumers, the traditional conspicuous consumption model has been transformed into a new experiential luxury sensibility that is marked by a change in the way that consumers define luxury. Based on an empirical study in collaboration with American, European, and Asian researchers, the results provide evidence that consumers in various parts of the world purchase or wish to purchase luxury products for varied reasons but that such consumers generally possess similar values. Regardless of their countries of origin, the basic motivational drivers of luxury consumers are similar among the financial, functional, personal, and social dimensions of luxury value perceptions, although the relative importance of these dimensions varies.
PENGARUH MANAJEMEN LABA, UKURAN PERUSAHAAN TERHADAP CORPORATE SOCIAL RESPONSIBILITY (CSR) DAN NILAI PERUSAHAAN PADA PERUSAHAAN MANUFAKTUR YANG TERCATAT DI BURSA EFEK INDONESIA TAHUN 2007-2010

Manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2007-2010. Penelitian ini bertujuan untuk meneliti pengaruh Manajemen Laba, Ukuran Perusahaan terhadap Corporate Social Responsibility (CSR). Penelitian Ini juga menguji pengaruh Manajemen Laba, Ukuran Perusahaan terhadap Nilai Perusahaanmelalui Corporate Social Responsibility (CSR). Pengumpulan data dilakukan pada perusahaan-perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia. Dari total populasi 151 perusahaan manufaktur, diperoleh 148 perusahaan yang melakukan Kegiatan Corporate Social Responsibility (CSR) selama periode pengamatan dan kemudian diuji dengan path analysis. Hasil penelitian menunjukkan bahwa manajemen laba tidah berpengaruh terhadap kegiatan Corporate Social Responsibility (CSR), sedangkan ukuran perusahaan berpengaruh positif dan signifikan terhadap Kegiatan Corporate Social Responsibility (CSR). Hasil penelitian juga membuktikan bahwa manajemen laba dan ukuran perusahaan tidak berpengaruh terhadap nilai perusahaan, sedangkan Kegiatan Corporate Social Responsibility (CSR) berpengaruh positif dan signifikan terhadap nilai perusahaan. Corporate Social Responsibility (CSR) bukan merupakan variabel yang memediasi pengaruh manajemen laba terhadap nilai perusahaan. Namun Corporate Social Responsibility (CSR) merupakan variabel yang memediasi pengaruh ukuran perusahaan terhadap nilai perusahaan. Hasil penelitian menyimpulkan bahwa investor di Indonesia menyukai perusahaan yang melakukan kegiatan Corporate Social Responsibility (CSR) karena kelangsungan usaha (going concern) perusahaan tidak akan terganggu dan kegiatan operasional perusahaan akan berjalan lancar sehingga dapat mempengaruhi nilai perusahaan. Kata Kunci : Manajemen Laba, Ukuran Perusahaan, Corporate Social Responsibility (CSR), Nilai Perusahaan
Reduced protein adsorption at solid interfaces by sugar excipients

Sugar excipients are shown to reduce the adsorption of ribonuclease A, bovine serum albumin, and hen egg white lysozyme at the liquid–solid interface. The amount of protein adsorbed decreased as the concentration of the sugar increased. At the same sugar concentration, the ability of sugars to reduce protein adsorption followed the trend: trisaccharides > disaccharides > 6‐carbon polyols > monosaccharides. This trend in adsorbed protein amounts among sugars was explained by stabilization of the protein native state in solution by the sugar excipients. The heat of solution of the amorphous saccharide was found to correlate with the amount of protein adsorbed. © 2004 Wiley Periodicals, Inc.
CONSUMER DECISION-MAKING STYLES AND YOUNG-ADULT CONSUMERS: AN INDIAN EXPLORATION

The economy of India is on a growth spree since the last two decades. This growth has increased the shopping options available to the consumers. The present study has tried to ascertain the decision-making styles of young-adult consumers so as to provide information to marketers interested in the decision-making profile of Indian consumers and thus enabling them to build their marketing efforts accordingly. The research has made use of Sproles and Kendall’s (1986) consumer styles inventory (CSI) on a sample of 425 young-adult Indian consumers and has attempted to examine the generalisability of the scale. Factor analysis has been employed to summarise the 38 variables identified into smaller sets of linear composites that preserved most of the information in the original data. The study has confirmed the applicability of the original US characteristics as well as two new traits specific to the Indian context. Furthermore, similarities and differences between different cultures have been discussed and implications have been proffered.
Clinical Implications of Mechanisms of Resistance to Antiepileptic Drugs

Background:Despite the currently available armamentarium of antiepileptic drugs, seizures are not adequately controlled in about one-third of epileptic patients. The mechanisms of antiepileptic drug resistance are multiple and not fully clarified. Methods:We conducted a literature search in PubMed and the Cochrane Library databases with the terms: “Drug Resistance” [MeSH] and “Epilepsy” [MeSH], Limits: added to PubMed in the last 5 years, only items with abstracts, English, Spanish, Humans. Review Summary:It is currently known that membrane transporter proteins are increased in brain tissue of refractory epileptic patients and in animal models of epilepsy and that overexpression of these transporters and their inhibition are correlated with a reduction and an increase, respectively, of epileptic drugs in epileptic tissue (pharmacokinetic hypothesis). It has also been shown that alterations in voltage-gated sodium channels and GABAA receptors are responsible for resistance to some epileptic drugs. These changes may be constitutional (genetically determined) or acquired (as a consequence of the seizures themselves or disease progression) and may seem alone or combined with each other (pharmacodynamic hypothesis). Associations have been shown between certain genetic polymorphisms and resistance to epileptic drugs, and although they have not been replicated by all authors, they constitute a very attractive line of research. More detailed knowledge of these molecular mechanisms will probably lead to the development of new strategies for pharmacological treatment of epilepsy.
Information Sharing in Joint Research and Development

In today's science-driven industries, such as the semiconductor industry, firms are increasingly engaged in across-firm research and development projects in the form of a research consortium or a strategic alliance. Those collaboration processes, however, have complex aspects due to the competing relationship of the firms in product markets and will not be successful unless the participating firms have enough incentives to reveal their private information and to exert sufficient efforts. The paper attempts to explore the conditions under which firms have enough incentives to reveal their information and/or to expend collaborative efforts. Three existing economic models are examined for this purpose. It is argued that those incentives depend upon the nature of competition in the product markets, information structure, and the way that each firm's private information affects this competition. The models examined in the paper suggest that some mechanism is necessary to evaluate private technical information of each firm and to convey it to the other firms without distortion. This conclusion coincides with the observed fact that a neutral third-party plays an indispensable role in a successful research consortium.
Are Malaysian Diabetic Patients Ready to Use The New Generation of Health Care Service Delivery? A Telehealth Interest Assessment.

BACKGROUND The idea of launching an internet-based self-management program for patients with diabetes led us to do a cross-sectional study to find out about the willingness, interest, equipment, and level of usage of computer and internet in a medium- to low-social class area and to find the feasibility of using e-telemonitoring systems for these patients. METHODS A total of 180 patients with type 2 diabetes participated in this study and fulfilled the self-administered questionnaire in Diabetes Clinic of Primary Medical Center of University Kebangsaan Malaysia Medical Centre; the response rate was 84%. We used the universal sampling method and assessed three groups of factors including sociodemographic, information and communication technology (ICT), willingness and interest, and disease factors. RESULTS Our results showed that 56% of the patients with diabetes were interested to use such programs; majority of the patients were Malay, and patients in the age group of 51-60 years formed the largest group. Majority of these patients studied up to secondary level of education. Age, education, income, and money spent for checkup were significantly associated with the interest of patients with diabetes to the internet-based programs. ICT-related factors such as computer ownership, computer knowledge, access to the internet, frequency of using the internet and reasons of internet usage had a positive effect on patients' interest. CONCLUSION Our results show that among low to intermediate social class of Malaysian patients with type 2 diabetes, more than 50% of them can and wanted to use the internet-based self-management programs. Furthermore, we also show that patients equipped with more ICT-related factors had more interest toward these programs. Therefore, we propose making ICT more affordable and integrating it into the health care system at primary care level and then extending it nationwide.
Expert system for pathological bacterial testing and determination of corresponding antimicrobial therapy

This is an attempt to develop an expert system for computer-guided of serial pathological bacterial testing to facilitate determination of antimicrobial therapy. If deem successful, the system could indirectly help reduce the cost of pathological testing and increase the efficiency of assignment of antimicrobial therapy to patients. Six common pathological tests, 19 infectious bacteria, and 16 recommended antimicrobial therapies were screened, identified, and selected. Decision table and decision tree are used in developing the knowledge base. Bayesian reasoning is employs for uncertainty management. Four user interface testers and one domain expert reviewer tested the usability of the system. The system has good potential but required further rigorous knowledge acquisition techniques, more breadth and depth in knowledge base contents, and better help facilities.
A DMOS integrated 320mW capacitive 12V to 70V DC/DC-converter for LIDAR applications

A 320mW integrated switched capacitor DC-DC converter is realized in a 0. 35µm DMOS high voltage technology. This 10 stage converter generates 70V from a 12V voltage supply, at a maximum efficiency of 85.5% per stage. An on-chip control system varies the clock frequency from 0 to 35.4MHz in order to regulate the output voltage at varying loads and supply voltages. Each of the stages uses an integrated capacitor of 74pF. The total area of the chip is 6mm2.