Miracle-dz/UniFAR-FTUs huggingface dataset:
Sepsis-Induced Immunosuppression in Neonates

Neonates, especially those born preterm, are at increased risk of sepsis and adverse long-term effects associated with infection-related inflammation. Distinct neonatal immune responses and dysregulated inflammation are central to this unique susceptibility. The traditional separation of sepsis into an initial hyper-inflammatory response followed by hypo-inflammation is continually under review with new developments in this area of research. There is evidence to support the association of mortality in the early acute phase of sepsis with an overwhelming hyper-inflammatory immune response. Emerging evidence from adults suggests that hypo- and hyper-inflammation can occur during any phase of sepsis and that sepsis-immunosuppression is associated with increased mortality, morbidity, and risk to subsequent infection. In adults, sepsis-induced immunosuppression (SII) is characterised by alterations of innate and adaptive immune responses, including, but not limited to, a prominent bias toward anti-inflammatory cytokine secretion, diminished antigen presentation to T cells, and reduced activation and proliferation of T cells. It is unclear if sepsis-immunosuppression also plays a role in the adverse outcomes associated with neonatal sepsis. This review will focus on exploring if key characteristics associated with SII in adults are observed in neonates with sepsis.
Robust Moving Sound Source Localisation

We formulate a novel Bayesian generative model for binaural sound source localisation using time delay estimation. This is a form of hiearchical hidden Markov model, including data association and second order time delay state. Learning of system parameters is performed with EM. Using a typical cluttered office test environment and custom moving sound source hardware, we perform a thorough quantative performance comparison of our new model with another state of the art localisation system, a multiple hypothesis tracking Kalman filter. The new model performs filtering in faster than real time, and is found to produce consistently less noisy filtered estimates than the state of the art, and better RMSE performance on some datasets.
Early Vision and Visual System Development

The visual system can be (and is) studied using many different techniques. In this course we will consider: Psychophysics What is the level of human visual performance under various different conditions? Anatomy Where are the visual system parts located, and what do they look like? Gross anatomy What do the visual system organs and tissues look like, and how are they connected? Histology What cellular and subcellular structures can be seen under a microscope?
Skin lesions in the form of eruptive xanthomasas - a first manifestation of severe hyperlipidaemia

The presence of eruptive xanthomas is associated with lipid disorders, particularly hypertriglyceridaemia. Intensified hypertriglyceridaemia >10 mmol/l (880 mg%) is a major risk factor for acute pancreatitis. The presented case concerns a 40-year-old man with skin lesions in the form of eruptive xanthomas, accompanied by hypertriglyceridaemiae, complicated by acute pancreatitis, and diagnosed with type 2 diabetes with glycated haemoglobin 9.7 g/dl. Seeding of skin lesions appeared 2–3 months before hospitalization and was observed in the direction of molluscum contagiosum.
Septic pulmonary embolism complicated by pyogenic spondylitis and psoas abscesses in a patient with methicillin-sensitive Staphylococcus aureus bacteraemia

Abstract Septic pulmonary embolism (SPE) is a rare condition, indicating bacteraemia. We report a rare case of Staphylococcus aureus bacteraemia causing SPE and multiple abscesses in a previously healthy patient. A previously healthy 33-year-old man presented to our hospital with fever and back pain for 3 weeks. Chest contrast-enhanced computed tomography image was suggestive of SPE, and the blood culture showed methicillin-susceptible S. aureus. Additional focus identification revealed pyogenic spondylitis and abscesses in the psoas muscles. After the 6-week antimicrobial treatment, his clinical condition and image findings improved, and he was discharged. SPE should be considered as a critical consequence of bacteraemia, and early focus identification is essential for appropriate treatment.
Increasing breastfeeding rates up to six months among primparous women : a quasi-experimental study of the effectiveness of the Milky Way Program

Aim: To evaluate effectiveness of The Milky Way Program in increasing rates of breastfeeding to six months. Method: Four hundred and twenty nulliparous women were recruited in the study. Women were surveyed in the antenatal period about baseline data. Postnatal data were collected at one, four and six months postpartum. The intervention was three antenatal breastfeeding sessions and two postnatal follow up phone calls. Results: Women in The Milky Way group had higher rates of breastfeeding at six months (54.3% vs. 31.4% p Discussion: The Milky Way Program was effective in prolonging breastfeeding up to six months.
Advances in the neurosurgical management of epilepsy caused by hypothalamic hamartoma

Abstract Hypothalamic hamartoma (HH) is an uncommon intrinsically epileptogenic lesion of the hypothalamus that is associated with medically intractable epilepsy. Intractable seizures caused by HH may lead to progressive cognitive delay and are also associated with generation of secondary epileptic foci. Therefore, early referral and surgery for children with HH is critical. Recent advances in minimally invasive neurosurgical techniques, including endoscopy, radiosurgery, magnetic resonance-guided laser interstitial ablation, and deep brain stimulation, have increased both the variety and feasibility of treatment options available for treating the intractable seizures caused by HH. In this manuscript, we review emerging techniques available for treatment of intractable seizures associated with HH.
Application Parameter Settings for TMS320DM365 H.264 Encoder

Texas Instrument's TMS320DM365 H.264 video encoder is a flexible implementation of the H.264 video encoder standard. It supports various profiles and features, each of which can be independently selected, set or controlled. This flexibility enables the TMS320DM365 H.264 video encoder to be used in a variety of different applications. This application report lists the different parameters that can be set to control the operation of the TMS320DM365 H.264 video encoder. Recommended values of the parameters for several applications scenarios, video conferencing, video security, video surveillance, video broadcast, video streaming, storage, local playback and digital video recorder (DVR) are provided. These recommended values enable the optimal usage of the video encoder for these application scenarios.
Restriction Gene Expression Profile of Aging and Its Retardation by Caloric

, 1390 (1999); 285 Science et al. Cheol-Koo Lee Restriction Gene Expression Profile of Aging and Its Retardation by Caloric This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): November 24, 2014 www.sciencemag. org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/285/5432/1390.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/285/5432/1390.full.html#ref-list-1 , 16 of which can be accessed free: cites 39 articles This article 830 article(s) on the ISI Web of Science cited by This article has been http://www.sciencemag. org/content/285/5432/1390.full. html#related-urls 100 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag. org/cgi/collection/physiology Physiology subject collections: This article appears in the following
Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells

Poorly-controlled diabetes mellitus is associated with the development of chronic vascular complications, which cause morbidity and premature mortality. Many studies have highlighted that maintenance of normal blood glucose levels in all people with diabetes is the most effective way in which chronic complications can be reduced and prevented. Presently, the underlying mechanisms associated with the manifestation and progression of vascular complications are poorly defined. Therefore, this study considered how the increased oxidative demand placed upon cells by high glucose concentration would result in a state of pseudo hypoxia, and potentially the expression of hypoxia-inducible factor-alpha (HIF-1alpha). In an animal model of diabetes, HIF-1alpha protein expression was seen to increase in the vasculature surrounding the sciatic nerve at ten- and twenty-four weeks of diabetes duration, which was seen to be reversed at twenty-four weeks in response to treatment with the antioxidant alpha-lipoic acid. In vitro, exposure of HUVEC to 20mM glucose for twenty-four hours induced perinuclear expression of HIF-1alpha protein, as opposed to nuclear expression evident under hypoxic conditions. Furthermore, at twenty-four hours in 20mM glucose, the detected HIF-1alpha mRNA level was significantly higher than that seen in all other conditions (p < 0.001). The increase in HIF-1alpha mRNA detected was seen to be dependent upon mRNA stability, and potentially its association with RNA-binding proteins and/or the natural antisense, aHIF. Pi3K - and, to a lesser extent, p42/44 MAPK signalling pathways - were also implicated, and alpha-lipoic acid treatment reversed the stability of HIF-1alpha mRNA. The effect of high glucose on HIF-1alpha mRNA level was not seen in response to partially/non-metabolisable glucose analogues, indicating glucose metabolism to be central to the stabilisation of HIF-1alpha mRNA. In conclusion, using the metabolism of high concentrations of glucose to regulate HIF-1alpha at the level of mRNA and protein may contribute to the generation of chronic vascular disease associated with diabetes, and should be further explored as a potential mechanism by which such complications may be prevented.
Novel Strategies for Malaria Vaccine Design

The quest for a licensed effective vaccine against malaria remains a global priority. Even though classical vaccine design strategies have been successful for some viral and bacterial pathogens, little success has been achieved for Plasmodium falciparum, which causes the deadliest form of malaria due to its diversity and ability to evade host immune responses. Nevertheless, recent advances in vaccinology through high throughput discovery of immune correlates of protection, lymphocyte repertoire sequencing and structural design of immunogens, provide a comprehensive approach to identifying and designing a highly efficacious vaccine for malaria. In this review, we discuss novel vaccine approaches that can be employed in malaria vaccine design.
Experiences Using Semi-Formal Methods During Development of Distributed, Research-Oriented, System-Level Software

The Management System for Heterogeneous Networks (MSHN) is a large, distributed research software system project that began over 18 months ago. The primary goal of MSHN is to develop a framework within which nextgeneration resource management system (RMS) issues can be investigated. The initial MSHN design was developed using basic object-oriented design principles and the initial prototype was built with object-oriented technology (IDL, C++, Java, and CORBA). After building an initial proof-of-concept prototype, we looked to the standardized terms, symbols and diagrams of the Unified Modeling Language (UML) to explain the functionality of MSHN to new students and staff members of the development group, as well as interested colleagues outside of the group. As we learned more about the UML and applied it to MSHN in further detail, we found that this semi-formal method not only (i) helped us to communicate MSHN’s functionality to others, but also (ii) improved our design, helping us identify bloated packages and opportunities for object re-use, and (iii) enabled us to more easily settle some open questions that had previously been sources of contention among the members of the MSHN team. Additionally, we found the Unified Process to be quite useful as a framework for building research-level, distributed systems software.
Hemoculturas: estudo da prevalência dos microrganismos e o perfil de sensibilidade dos antibióticos utilizados em Unidade de Terapia Intensiva

Objetivo - O trabalho apresentado tem como objetivo o estudo sobre a prevalencia de hemoculturas positivas provenientes de pacientes hospitalizados em Unidade de Terapia Intensiva (UTI), e determinar os principais microrganismos presentes nessas amostras, bem como, analisar o perfil de sensibilidade dos principais antibioticos. Metodos - Durante o periodo de janeiro a julho de 2011, foram analisados os resultados de 512 coletas de hemoculturas, dentre elas 308 (60,2%) eram do sexo masculino e 204 (39,8%) do sexo feminino. Resultados - A positividade foi de 24%. Numa analise geral, Staphylococcus epidermidis foi o microrganismo de maior prevalencia (45,5%), seguido por Staphylococcus aureus (13,0%) e Pseudomonas aeruginosa (12,2%). A resistencia a antibiotico foi maior para oxacilina (80,1%). Conclusoes - O estudo mostrou que Staphylococcus sp resistentes a oxacilina e uma das principais causa de bacteremia em UTI. (AU) Objective - The work presented has goals to study about the prevalence of blood cultures from patients hospitalized in the Intensive Care Unit (ICU), and determine the main microorganisms present in these samples, as analyze the sensitivity of the main antibiotics. Methods - During the period from January to July 2011 were analyzed the results of 512 tests from blood cultures, among them 308 (60.2%) were male and 204 (39.8%) females. Results - The positivity was 24%. In a general analysis, Staphylococcus epidermidis was the microorganism most prevalent (45.5%), followed by Staphylococcus aureus (13.0%) and Pseudomonas aeruginosa (12.2%). The antibiotic resistance to oxacillin was higher(80.1%). Conclusions - The study showed that Staphylococcus sp is a main causes of bacteremia in ICU. (AU)
Tuning the Parameters of a Loading Algorithm

ORTEC is one of the largest global providers of software solutions for complex decision-making problems. The newly developed software tool ORTEC Pallet and Load Building (OPLB) aims to facilitate container loading processes for customers worldwide. It contains a heavily parameterized algorithmic framework of which the performance on customer-specific problem instances depends on the quality of its parameter configuration. These parameters form the subject of this research. We propose uRace, an innovative unified Race algorithm that ensures efficient offline parameter tuning of deterministic, categorically parameterized algorithms. Using uRace to tune the parameters of OPLB, we outperform known constructive heuristics in the literature on both an academic and a practical problem set, while showing competitive results on academic benchmark problems compared to state-of-the-art loading algorithms.
A measurement framework for the parameterization of performance models of SOA-based systems

Distributed applications are rapidly converging towards the adoption of a computing paradigm based on service-oriented architectures, according to which an application can be seen as a composite web service that is built by assembling a set of existing services, executed on internetworked server hosts. In such a context, service providers are strategically interested both to describe the performance characteristics of offered services, to better qualify their offer and gain a significant advantage in the global marketplace; and to predict the level of performance that can be offered to service consumers. To this purpose, the paper introduces a framework for the management of performance parameters, defining the architecture that enables service providers to measure and make available performance information about the offered services. On the other hand the proposed approach allows the service consumers to automatically retrieve the performance data and then use such data to apply model-driven approaches for the performance analysis of composite web services.
Networking and Online Games: Understanding and Engineering Multiplayer Internet Games

Author Biographies. Acknowledgements. 1 Introduction. 2 Early Online and Multiplayer Games. 2.1 Defining Networked and Multiplayer Games. 2.2 Early Multiplayer Games. 2.3 Multiplayer Network Games. 3 Recent Online and Multiplayer Games. 3.1 Communication Architectures. 3.2 The Evolution of Online Games. 3.3 Summary of Growth of Online Games. 3.4 The Evolution of Online Game Platforms. 3.5 Context of Computer Games. 4 Basic Internet Architecture. 4.1 IP Networks as seen from the Edge. 4.2 Connectivity and Routing. 4.3 Address Management. 5 Network Latency, Jitter and Loss. 5.1 The Relevance of Latency, Jitter and Loss. 5.2 Sources of Latency, Jitter and Loss in the Network. 5.3 Network Control of Lag, Jitter and Loss. 5.4 Measuring Network Conditions. 6 Latency Compensation Techniques. 6.1 The Need for Latency Compensation. 6.2 Prediction. 6.3 Time Manipulation. 6.4 Visual Tricks. 6.5 Latency Compensation and Cheating. 7 Playability versus Network Conditions and Cheats. 7.1 Measuring Player Tolerance for Network Disruptions. 7.2 Communication Models, Cheats and Cheat-Mitigation. 8 Broadband Access Networks. 8.1 What Broadband Access Networks are and why they Matter. 8.2 Access Network Protocols and Standards. 8.3 Cable Networks. 8.4 ADSL Networks. 8.5 Wireless LANs. 8.6 Cellular Networks. 8.7 Bluetooth Networks. 8.8 Conclusion. 9 Where Do Players Come from and When? 9.1 Measuring Your Own Game Traffic. 9.2 Hourly and Daily Game-play Trends. 9.3 Server-discovery (Probe Traffic) Trends. 9.4 Mapping Traffic to Player Locations. 10 Online Game Traffic Patterns. 10.1 Measuring Game Traffic with Timestamping Errors. 10.2 Sub-second Characteristics. 10.3 Sub-second Packet-size Distributions. 10.4 Sub-Second Inter-Packet Arrival Times. 10.5 Estimating the Consequences. 10.6 Simulating Game Traffic. 11 Future Directions. 11.1 Untethered. 11.2 Quality of Service. 11.3 New Architectures. 11.4 Cheaters Beware. 11.5 Augmented Reality. 11.6 Massively Multiplayer. 11.7 Pickup and Putdown. 11.8 Server Browsers. 12 Setting Up Online FPS Game Servers. 12.1 Considerations for an Online Game Server. 12.2 Wolfenstein Enemy Territory. 12.3 Half-Life 2. 12.4 Configuring FreeBSD's Linux-compatibility Mode. 13 Conclusion. 13.1 Networking Fundamentals. 13.2 Game Technologies and Development. 13.3 A Note Regarding Online Sources. Index.
Inclusion of traditional Maya healing in health care

By Todd Pesek, MD Introduction Traditional Healing (TH) and Complementary and Alternative Medicine (CAM) are related fundamentally through their philosophy and practice. TH remains widespread in developing countries while CAM is growing rapidly in developed countries. This market force drives globally policy-makers, researchers, practitioners and the public to elucidate answers on questions of safety and efficacy; availability; preservation; and viable, sustainable implementation strategies toward this type of healthcare.
Texture and structure of opal-CT and opal-C in volcanic rocks

Textues and structures of opal-CT and opal-C in volcanic rocks fiom the Hoseka aad Akase opal mines in Japan were studied using an optical miooscope and scanning and transmission electron microscopes. Textures ofthe opal-CT are optically classified into anisotropic colnmnar and isoFopic m:ssive (opal-CTy) type,s. Botl tex0rres consist of rhin and platy crysrgls showing ffio wide { 101} faces of low crisobalite.Image,s obtained by high-resolution transmission electronmicroscopy show that the cristobalite strucfilreis thefundamentalcomponentof volcanic-typeopalCl, andthat many sacking faults arepresentrandomly in thestructure. Columns arepoduced by parallel growth ofplaty crystals; opal-CTy and lepispheres consist ofcriss-crossing aggregafes ofblades. Each blade is composed ofroughly parallel aggregates ofplaty crystals. The variation ofdror values with texoral and strucaual changes of the opal-CT was measured by an X-ray powderdiftaction methd. With decrease of d161 value, higbly ordered cristobalite domains develop surrounding the domains ofdisordered cristobalite in the crystal. The considerable difference in degree oforder of stacking bet'ween the two types of domain implies changes in the growth process of the crystal.
Integrity Coded Databases (ICDB) - An Evaluation of Efficiency, Performance, and Practicality

Recently, cloud database storage has become an inexpensive and convenient option to store information; however, this relatively new area of service can be vulnerable to security breaches [1]. Storing data in a foreign location requires the owner to relinquish control of their information. This opens the possibility for internal, malicious attacks that can involve the manipulation, omission, or addition of data [2].
Influence of Discharge and Сhаnnеl Gеоmеtry on Sеераgе Losses from Sесоndаry Саnаl

Sеераgе is thе mоst serious fоrms оf wаtеr loss in аn irrigаtiоn саnаl nеtwоrk. Sеераgе lоss mоstly dереnd оn thе сhаnnеl gеоmеtry. Еxсеssivе sеераgе lоssеs саn саusе wаtеr lоgging аnd sоil sаlinity duе tо whiсh thе сultivаblе аrе rеduсеd, аnd rеsults in а lоss оf роtеntiаl сrор рrоduсtiоn. In this рареr, sеераgе lоss frоm а (Sаrki Minоr) thаt оff tаkеs frоm Shаhu brаnсh оf Jаmаrао саnаl wаs dеtеrminеd. Rеlеvаnt hydrаuliс dаtа wаs rесоrdеd аt strаtеgiс lосаtiоns аnd sеераgе lоssеs wеrе mеаsurеd by inflоwоutflоw mеthоd rеsресtivеly. Linеаr rеgrеssiоn wаs еmрlоyеd tо dеvеlоре еmрiriсаl rеlаtiоns fоr соmрuting sеераgе lоssеs with rеsресt tо сhаnnеl gеоmеtry. АА-Tyре аnd рygmy сurrеnt mеtеrs wаs usеd tо mеаsurе thе disсhаrgе аt thе diffеrеnt sесtiоn. Thе rесоrdеd dаtа оf hydrаuliс сhаrасtеristiсs wаs соrrеlаtеd using linеаr rеgrеssiоn аnаlysis tо dеvеlор аn еmрiriсаl еquаtiоn fоr sеераgе lоssеs with сhаnnеl gеоmеtry раrаmеtеrs. Thе results rеvеаlеd thаt thе mаximum sеераgе lоssеs wеrе аt 0-5RD (4%) fоllоwеd by 5-10RD (3.4%), 10-15RD (3.4%) 15-20RD (3.5%), аnd thеn 20-25RD (2.9%) аnd оvеr аll sеераgе lоssеs wаs 17% in thе minоr. Statistical analysis (LRA) shows significantly positive relationship at (Р<0.05) fоr sеераgе lоssеs and disсhаrgе (r 2 =0.962), wеttеd реrimеtеrs (r 2 =0.943), flоw аrеа (r 2 =0.914) аnd tор width (r 2 =0.967). Thеsе еquаtiоns соuld bе usеd tо еstimаtе саnаl sеераgе lоssеs withоut gоing thrоugh thе соnvеntiоnаl mеthоd.