Miracle-dz/UniFAR-FTUs huggingface dataset:
Elucidating the cause of FAT10 over-expression in liver and colon carcinomas

Acknowledgments First of all, I would like to thank Prof. Dr. Marcus Groettrup for giving me the opportunity to do this work in his lab, where I began as a diploma student. He provided me with important advice and constant support during my work. Many thanks also go to … Gunter Schmidtke, who was always open to give me advice, not only in biochemical terms My fellow PhD students on the FAT10 project, especially Birte Kalveram, Christiane Pelzer, Kathrin Kluge and our " Pretty Queen " Neha Rani for a lot of fun in the lab Marc Müller and Annette Sommershof for nice coffee breaks on the roof and beer at " Klimperkasten " My dear friend Khalid, a constant source of high spirits and amusement, who taught me some " nice " Hindi words All my colleagues in the Groettrup lab, who made the time that I spend here really enjoyable! Gerardo for making great Caipirinha's during fantastic lab parties. Elmar Spies for many, many hours on our road bikes, his delicious Käßspätzle and for " The Pump " Peter Öhlschläger, for being an extraordinary person and friend I am really grateful to Anja Holtz, for pleasant coffee breaks, her delicious cakes and many stimulating discussions on any topic. I am also very thankful to Christopher, for being my friend since the first day in Konstanz! Najbardziej chciałbym podziekować mojej rodzinie, która zawsze we mnie wierzyła i mi pomagała jak tylko mogła.
Heart Rate Variability

The last two decades have witnessed the recognition of a significant relationship between the autonomic nervous system and cardiovascular mortality, including sudden cardiac death. Experimental evidence for an association between a propensity for lethal arrhythmias and signs of either increased sympathetic or reduced vagal activity has encouraged the development of quantitative markers of autonomic activity. Heart rate variability (HRV) represents one of the most promising such markers. The apparently easy derivation of this measure has popularized its use. As many commercial devices now provide automated measurement of HRV, the cardiologist has been provided with a seemingly simple tool for both research and clinical studies. However, the significance and meaning of the many different measures of HRV are more complex than generally appreciated and there is a potential for incorrect conclusions and for excessive or unfounded extrapolations. Recognition of these problems led the European Society of Cardiology and the North American Society of Pacing and Electrophysiology to constitute a Task Force charged with the responsibility of developing appropriate standards. The specific goals of this Task Force were to: standardize nomenclature and develop definitions of terms; specify standard methods of measurement; define physiological and pathophysiological correlates; describe currently appropriate clinical applications, and identify areas for future research. In order to achieve these goals, the members of the Task Force were drawn from the fields of mathematics, engineering, physiology, and clinical medicine. The standards and proposals offered in this text should not limit further development but, rather, should allow appropriate comparisons, promote circumspect interpretations, and lead to further progress in the field. The phenomenon that is the focus of this report is the oscillation in the interval between consecutive heart beats as well as the oscillations between consecutive instantaneous heart rates. ‘Heart Rate Variability’ has become the conventionally accepted term to describe variations of both instantaneous heart rate and RR intervals. In order to describe oscillation in consecutive cardiac cycles, other terms have been used in the literature, for example cycle length variability, heart period variability, RR variability and RR interval tachogram, and they more appropriately emphasize the fact that it is the interval between consecutive beats that is being analysed rather than the heart rate per se. However, these terms have not gained as wide acceptance as HRV, thus we will use the term HRV in this document.
The Effect of Pregnancy on the Control of Lipolysis in Fat Cells Isolated from Human Adipose Tissue

Abstract. 1. Lipolysis has been estimated by measuring the release of glycerol in isolated adipose tissue cells obtained from women in early prognancy, late pregnancy and 1–3 days post partum and from non‐pregnant women. 2. Adipocytes of women at the end of pregnancy exhibited higher rates of lipolysis in response to adrenaline (1. 5–15 μM) plus phentolamine (13 μM) than those of non‐pregnant women or those in early pregnancy. 3. Lipolysis in response to adrenaline plus phentolamine in fat cells from women 1–3 days post partum was reduced compared to that at the end of gestation but was enhanced relative to that in the non‐pregnant or early pregnant state. 4. Basal lipolysis also tended to be greatest at term. 5. Under conditions where the production of cyclic AMP was not rate limiting for the stimulation of lipolysis, that is in the presence of dibutyryl cyclic AMP (1 mM) or adrenaline (15 yM) plus phentolamine (13 μM) plus caffeine (1 mM), the release of glycerol in cells from women at term and in the puerperium was greater than that in women in the non‐pregnant or early pregnant state. 6. Cell levels of cyclic AMP rose after incubation with adrenaline (6 μM) plus phentolamine or adrenaline (15 μM) plus phentolamine plus caffeine (1 mM) but were similar in all four groups of women. 7. It is concluded that the observed enhancement of lipolysis demonstrated in fat cells from women at the end of pregnancy reflects an increase in hormone‐sensitive lipase activity rather than a modification of hormone receptor site sensitivity or of the rates of synthesis or breakdown of cyclic AMP. 8. This increase in adipose tissue lipolysis at the end of gestation could contribute to the reported rise in plasma nonesterified fatty acids in the final weeks of pregnancy.
臨床エビデンス産科学 : Evidence‐based medicine

合併症妊娠（心・血管疾患；呼吸器疾患；消化器疾患—肝、胆、膵疾患 ほか） 胎児異常（胎児形態異常；胎児水腫・腔水症；ＩＵＧＲ ほか） 産褥期（産褥の管理と検診；乳汁分泌の促進と抑制；精神神経症状とその管理—マタニティーブルーズを中心に）〔ほか〕
A Cross Sectional Study on Knowledge, Attitude and Practice of Hepatitis B Vaccination Among Medical Students in Malaysia

Transmission of HBV commonly occurs through exposure to bodily fluids, therefore putting health care workers at a higher risk of becoming infected. It is important for the medical students to have a good knowledge, attitude and practice regarding Hepatitis B vaccination. A questionnaire based analytical cross sectional study was used to conduct the study of knowledge, attitude and practice of hepatitis B vaccination among the medical students of private medical college in Malaysia. Participants of this study comprised of 3rd and 4th academic year students who have enrolled for MBBS in private medical college in Malaysia. The sample size of this research is 171 students. The questionnaire consisted of 4 sections, which are demographic details, attitude and practice of Hepatitis B vaccination. For qualitative data such as gender, race and socioeconomic status are calculated by using frequency, percentage and mode. The hypothesis tested by applying the Unpaired t test, ANOVA and binary logistic regression, odds ratio and 95% CI were used to measure the associations. In this research, 95.91% of the students were vaccinated against Hepatitis B (HBV) and 74.85% of the students had full doses (3 doses) of HBV vaccine. 92.4% of the students had moderate to good attitude and knowledge regarding HB vaccination. There is no significant association between gender (P=0.565), ethnicity (P=0.135), socioeconomic status (P=0.593) and knowledge (P=0.066) with practice of HBV vaccination. Female has 3.69 attitudes percentage score higher than male with a significant association (P<0.001). Chinese has higher attitude mean score (mean=85.53%) compared with Indian (mean=82.42%), Malay (mean=73.79%) and other ethnicities (mean=83.28%), this has significant association (P=0.002). Lower (mean=64.81%) socioeconomic status also shows lower attitude mean score compared with upper class (mean=82.37%), upper middle class (mean=83.09%), lower middle class (mean=82.28%) and working class (mean=81.48%), this has significant association (P=0.001). There is significant association between attitude and knowledge of HBV vaccination (P=0.002), students with good attitude mean score were 1.09 more likely to have better practice of Hepatitis B vaccination. The medical students who were not completed the full doses of Hepatitis B vaccination requirement should be educated on the importance of hepatitis b vaccination. We recommend the future studies to collect responses from all academic years so that the study would be of higher significance.
A Morning in Clinic.

Families with young children attend well-child visits in pediatric primary care settings frequently during the first 3 years of life and receive information and answers to questions about their young child’s health and development. Integrating an infant– early childhood mental health and child development specialist into a pediatric primary care setting provides additional supports and resources to families with young children. This article describes the families seen by a developmental specialist working in an urban primary care clinic serving high-risk, low-income families during one morning in clinic. The diversity and complexity of infant mental health and developmental issues brought by families to their pediatric providers and the value of seeking reflective supervision for integrated clinicians
Idiopathic Intracranial Hypertension: The Monster Within

Idiopathic intracranial hypertension (IIH) is defined as a syndrome of raised intracranial pressure with normal imaging of the brain and cerebrospinal fluid (CSF) composition. There are many controversies and myths that surround IIH. Although patients of IIH may present “typical” symptoms and signs of raised intracranial pressure, clinical scenarios often vary. A typical clinical and radiological finding poses significant problems in diagnosis and management of patients with IIH. We have tried to resolve these controversies and provide a comprehensive update on different aspects of IIH. In this article, we review the common problems encountered while dealing with patients of IIH.
Der Einsatz von Clopidogrel bei Patienten mit akuten Koronarsyndromen, nach perkutaner koronarer Intervention und Stentimplantation

The Use of Clopidogrel in Patients with Acute Coronary Syndrome and after PCI and Stent Implantation. Clopidogrel is one of the best investigated antithrombotic agents in acute coronary syndromes at present. Nevertheless, some questions remain open and are the focus of discussion in this overview. Still unanswered questions include the “optimal loading dose”, pre-hospital use, peri-procedural
Positivity and prevalence of human papillomavirus among a large population of women in southeastern China

Objective To formulate strategies for prevention of cervical cancer, we investigated the prevalence of human papillomavirus (HPV) infection and the age-specific distribution among female participants in southeastern China. Methods From January 2016 to July 2018, 36,871 women from Meizhou People’s Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University were enrolled in this prospective study. HPV genotypes were detected using Luminex technology. Results HPV infection was observed in 18.34% of the participants, and 79.98% were infected with high-risk HPVs. The five most prevalent genotypes were HPV52 (18.18%), HPV16 (16.06%), HPV58 (11.37%), HPV53 (8.82%), and HPV39 (6.42%). The 9-valent HPV vaccine efficiently reduced the HPV infection rate by more than 10%, which is twofold the rate of other vaccines. Most HPV infections were observed in women age 40 to 49 years, and those age 30 to 59 years accounted for 79.62% of positive patients. Conclusion Our findings regarding HPV genotypes and the age-specific distribution of HPV infection in the study area will contribute to the development of cervical cancer screening programs and vaccine strategies.
POTENTIAL DRUG-DRUG INTERACTIONS IN HEART FAILURE PATIENTS

Objective: The aim of the present study was to assess the prevalence, risk rating and the severity of hazardous pDDIs (potential drug-drug interactions) in the prescribed pharmacotherapy in the hospital discharged heart failure (HF) patients, primarily with co-administered drugs with narrow therapeutic index (statins, anticoagulants, antithrombotic drugs). Methods: The prescriptions of chronic heart failure patients for one year (January-December 2014) were analyzed for pDDIs through Lexi-interact® software. DDIs belonging to the categories D (Consider therapy modification) and X (Avoid combination) and/or severity of drug interaction-major, were selected for the study. Results: After reviewing the medical records of 985 patients, 239 patients were selected based on the criteria mentioned above. The average number of prescription drugs at hospital discharge was 7.27 medications (±1.84 SD) per patient. The total number of pDDIs was 1483 or approximately 6.2 (±3.89 SD) pDDIs per patient. With respect to the risk rating, in categories D and X were detected 76 (5.12 %) and 2 (0.13 %) pDDI, respectively. The major pDDIs were 108 (7.28 %). Conclusion: HF patients are at high risk of pDDIs. Screening of prescriptions for pDDIs and monitoring of pharmacotherapy in terms of response and associated adverse drug events will contribute to patient safety.
Factors affecting Bone Mineral Density in Type 2 Diabetic Female Patients Referred to Dual-energy X-ray Absorptiometry Scan (DXA-Scan)

Objectives: To identify factors affecting bone mineral density (BMD) in Type 2 Diabetes Mellitus (T2DM) female patients referred to DXA-Scan. Method: We conducted a retrospective cohort study at tertiary care hospital in Ajman, United Arab Emi rates (UAE), and reviewed electronic hospital records for patients referred to DXA-Scan. Based on inclusion and exclusion criteria, 569 were enrolled in the study; diabetic and control groups. Results: Diabetic group showed significantly higher percent of liver impairment (p ≤ 0.01), renal impairment (p ≤ 0.001), and had significantly higher comorbid conditions such as depression (p ≤ 0.01), hypertension (p ≤ 0.001), dyslipidemia (p ≤ 0.001), Ischemic Heart Disease (IHD) (p ≤ 0.001) and osteoarthritis (p ≤ 0.01), as well as taking significantly higher medications compared with control group. The result from stepwise multiple linear regression analysis showed that BMD in the diabetic group can be predicted by weight, height, body mass index, age, systolic blood pressure, diastolic blood pressure, stroke, hypothyroidism, fracture, and taking thyroid hormone, oral steroids and anticonvulsant with variation based on skeletal site. Conclusion: Many diseases and medication-related variables can predict BMD values in diabetic and control groups.
Aren’t All Directors Busy? Evidence from Director Workload and Attendance

All directors, not only those with multiple directorships, are potentially too busy to fulfill their directorial duties. Thus, as a general test of director busyness, we examine how changes in workloads (board and committee meeting frequency) affect the attendance practices of CEOs and directors. We find that attendance rates for both outside and inside directors decrease (non-random absences increase) when they are required to attend more board meetings. The marginal effect is that the average outside (inside) director has a 14 percent (12 percent) likelihood of missing an additional board meeting. Further analysis shows that this negative relationship between board meetings and attendance rates is consistent across directorships in a range of firms, including when more meetings are associated with poor performance, M&A activity and CEO turnover. The results for committee meetings are mixed, highlighting that director attendance is not consistent across different types of meetings. In summary, our analysis indicates that the average director is busy and has a limited ability to attend additional board meetings. Thus, any benefits firms obtain from holding additional meetings are being eroded by lower director attendance.
Formulating a health quality improvement strategy for developing countries : Challenges and opportunities

Many quality methods used in the west are not appropriate in this situation. There is a need to find a “way to quality” which is appropriate. Several studies show that most people in developing countries are not satisfied with the quality of public and private care and feel that something should be done. Even health care staff members derive greater personal and professional satisfaction from their jobs when they can offer good-quality care and can feel their work is valuable. Some studies argue that the most satisfying aspect of physicians jobs was helping people and the community recognition they received for it.
Rapid diagnostics test for detecting Chagas disease - Breaking barriers to diagnosis access in remote areas

Volume 4: 1-2 technique. The transmission occurs most often in populations far from urban centers, where access to health coverage is reduced and traveling to locations where more complex services are available is very difficult. It is also common in some areas in developing countries for births to occur without any control and, therefore, that children do not have access to laboratory testing for early detection of congenital transmission. Likewise, in unexpected situations in which an emergency transfusion is required, sometimes people must choose between the risk involved in the delay caused by the transfer of the patient and the risk of using blood unscreened for Chagas.
Implementation and Effectiveness of community-based resources to increase cervical cancer screening uptake among women living in sub-Saharan Africa: A protocol for systematic review

# Background Sub-Saharan Africa (SSA) accounts for about 70% of the global burden of cervical cancer; this is due to several factors including lack of access to cervical cancer screening, low knowledge of cervical cancer and screening services, poor-functioning health systems, insufficient and poorly trained health workers, and the high burden of human immunodefiency virus (HIV) infection. To date, to the best of our knowledge, there has been no systematic review of the literature on the role of community-based resources such as community health workers and community-based organisations in increasing the uptake and or continuing participation of women in cervical cancer screening, in the setting of high HIV burden, in sub-Saharan Africa. # Methods We will systematically search selected databases and websites from 1980 to date for published and grey literature including citation and reference list tracking, on studies with a community focus carried out in sub-Saharan Africa, without language restrictions. Randomised controlled trials (RCTs), observational studies, and qualitative and mixed methods studies of interventions (carried out with and without comparison groups) reporting impact on participation in cervical cancer screening in sub-Saharan Africa will be identified and assessed for methodological quality by two independent reviewers. We will use narrative synthesis and/or meta-analysis depending on the study selection. # Results Findings will be summarised into abstracts for presentation at conferences and submission to peer-reviewed journals in the field for wide-ranging dissemination to patients, researchers, healthcare professionals and policy makers on cervical cancer in sub-Saharan Africa. # Conclusion The review will address the gap in evidence for effective and implementable community-based strategies that encourages uptake of cervical cancer screening among women living in sub-Saharan Africa. The findings will have the potential to inform future screening practice and research with the hope of reducing the burden of cervical cancer in the region. # PROSPERO registration number -- CRD42018102539.
Appearance and Reality in the Sunshine State: The Talented 20 Program in Florida.

Author(s): Marin, Patricia; Lee, Edgar K. | Abstract: After a review of Florida state and institutional data and interviews with staff at five campuses of the Florida State University System and several Florida state agencies, this report describes the history, implementation, and effects of the Talented 20 Program. The report concludes that Talented 20 Plan is, in fact, not race-neutral and is not an effective alternative to race-conscious affirmative action.Also available at: http://civilrightsproject.ucla. edu
Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-κB Pathways

Testicular structural and functional impairment is a serious complication in male diabetes mellitus (DM) patients that leads to impaired fertility in adulthood. In contrast to other endocrine therapies, islet transplantation (IT) can effectively prevent and even reverse diabetic nephropathy and myocardial damage. However, whether IT can alleviate diabetes-induced testicular injury remains unclear. In this study, we sought to investigate the effect of IT on diabetes-induced testicular damage. A diabetic rat model was established by streptozotocin injection. DM, IT, and insulin treatment (INS) groups were compared after 4 weeks of respective treatment. We confirmed that IT could effectively attenuate diabetes-induced testicular damage and recover sperm counts more extensively compared with INS in diabetic rats. In addition, significantly higher levels of superoxide dismutase (SOD) activity and lower contents of malondialdehyde (MDA) were detected in the testes of the IT group versus diabetic rats. Mechanism studies revealed that IT significantly activates the expression of Nrf-2, HO-1, and NQO-1 and inhibits upregulation of the NF-κB expression in response to DM, while INS only exhibit slight impact on the protein expression. Therefore, we speculate that IT may prevent the progression of testicular damage by downregulating oxidative stress and inhibiting inflammation via Nrf-2/HO-1 and NF-κB pathways.