Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding Business Ecosystem Dynamics: A Data-Driven Approach

Business ecosystems consist of a heterogeneous and continuously evolving set of entities that are interconnected through a complex, global network of relationships. However, there is no well-established methodology to study the dynamics of this network. Traditional approaches have primarily utilized a single source of data of relatively established firms; however, these approaches ignore the vast number of relevant activities that often occur at the individual and entrepreneurial levels. We argue that a data-driven visualization approach, using both institutionally and socially curated datasets, can provide important complementary, triangulated explanatory insights into the dynamics of interorganizational networks in general and business ecosystems in particular. We develop novel visualization layouts to help decision makers systemically identify and compare ecosystems. Using traditionally disconnected data sources on deals and alliance relationships (DARs), executive and funding relationships (EFRs), and public opinion and discourse (POD), we empirically illustrate our data-driven method of data triangulation and visualization techniques through three cases in the mobile industry Google’s acquisition of Motorola Mobility, the coopetitive relation between Apple and Samsung, and the strategic partnership between Nokia and Microsoft. The article concludes with implications and future research opportunities.
Principios básicos de las nuevas estrategias farmacológicas antiarrítmicas en fibrilación auricular

Atrial fibrillation (AF) is the most common sustained arrhythmia seen in clinical practice. Despite of new technological breakthroughs and the understanding of the mechanisms underlying AF, based on animal models and ablation procedures in patients, the antiarrhythmic drugs remain the main therapeutic strategy to restore and maintain the sinus rhythm. New antiarrhythmic drugs are already available in the clinical practice and many others are under development. The new antiarrhythmic drugs have the capability to block atrial-specific ionic currents, which are involved in the maintenance of the arrhythmia. Parallel, increasing evidence supports the use of compounds to regulate the arrhythmogenic atrial substrate involved in the long-term maintenance of the arrhythmia (upstream therapies). This article reviews the new antiarrhythmic drugs and upstream therapies, based on the current knowledge of the mechanisms involved in the maintenance of AF.
Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience

Malignantly transformed cells can express aberrant cell surface glycosylation patterns, which serve to distinguish them from normal cells. This phenotype provides an opportunity for the development of carbohydrate-based vaccines for cancer immunotherapy. Synthetic carbohydrate-based vaccines, properly introduced through vaccination of a subject with a suitable construct, should be recognized by the immune system. Antibodies induced against these carbohydrate antigens could then participate in the eradication of carbohydrate-displaying tumor cells. Advances in carbohydrate synthetic capabilities have allowed us to efficiently prepare a range of complex, synthetic anticancer vaccine candidates. We describe herein the progression of our longstanding carbohydrate-based anticancer vaccine program, which is now at the threshold of clinical evaluation in several contexts. Our carbohydrate-based anticancer vaccine program has evolved through a number of stages: monomeric vaccines, monomeric clustered vaccines, unimolecular multi-antigenic vaccines and dual-acting vaccines. This account will focus on our recently developed unimolecular multi-antigenic constructs and potential dual-acting constructs, which contain clusters of both carbohydrate and peptide epitopes.
The Effect of Computer-Based Cognitive Training Program On Cognition

Background: Effective non-pharmacological cognitive program to prevent Alzheimer’s dementia or slow its progression are an urgent international priority. The effect of computer-based cognitive training program has not been demonstrated yet in dementia. The purpose of this study is to know whe ther the computer-based cognitive training improved cognitive abilities in patients with mild cognitive disorder and early stage of dementia. Methods: Totally 20 participants (14 with MCI and 6 with mild Alzhie mer dementia) participated in this study. To test the effectiveness of computer-based cognitive training programs to cognition, all patient were randomly allocated to an intervention group (n= 10) or a control group (n= 10) An intervention group received regularly computer-based cognitive training totally 20 times for 10 weeks. Neuropsychological examinations were conducted before and after this period. Results: After 10 weeks, intervention group showed a significant change in language of K-MMSE compared with baseline cognitive examinations. Also, there was improvement in attention (backward digit span), calculation, memory, and frontal function for the intervention group as compared with controls. Patients with mild cognitive disorder showed marked improvements in language and visuospatial capacity, while patients with dementia showed no or slight improvement in these fields. Conclusions: Computer-based cognitive training program might have beneficial effect on general cognitive function in both mild cognitive disorder and dementia. Especially, conspicuous effectiveness showed in patients with mild cognitive disorder. Received: November 14, 2013 Revision received: December 11, 2013 Accepted: December 11, 2013
Noninvasive diagnosis of non-melanoma skin cancer: focus on reflectance confocal microscopy

Non-melanoma skin cancer (NMSC) represents the most common cutaneous neoplasms and, in the past decade, nonsurgical treatment modalities have been established as part of the management of NMSC. Recently, novel noninvasive diagnostic modalities have been developed and, of these, reflectance confocal microscopy (RCM) offers imaging of the skin in vivo with cellular resolution. NMSCs, including basal cell carcinoma, actinic keratosis and squamous cell carcinoma, have been evaluated by RCM, and diagnostic criteria were defined. By correlation with routine histology sections and in comparison with normal skin, RCM showed high sensitivity and specificity values. RCM allows the noninvasive evaluation of a variety of skin conditions, including NMSC. RCM may aid in the diagnosis and differential diagnosis of NMSC, as well as in monitoring of treatment response to topical treatment modalities. Therefore, RCM appears to be a promising diagnostic tool with many possible applications in dermatology.
Retinopathy of prematurity: recent developments in diagnosis and treatment

Retinopathy of prematurity (ROP) is a potentially blinding disorder of extremely premature infants caused by un-physiologic oxygen supply within the first weeks of life. The disease is characterized by uncontrolled vessel growth at the border of the vascularized zone, in severe cases leading to vitreoretinal tractions and retinal detachment. About 3–5% of all ROP cases need treatment at some point. The use of digital wide-field fundus photography, fluorescein angiography and optical coherence tomography as diagnostic tools generated a wealth of information about early disease features and treatment effects. Currently, intravitreal anti-VEGF injections are considered by many to be the optimal treatment approach for the most severe forms of Type 1 ROP, even though the pharmacological risks in terms of organ development and mortality rate have not yet been fully addressed.
Neisseria meningitidis B vaccines

Invasive infections caused by Neisseria meningitidis are a serious public health problem worldwide and have a heavy economic impact. The incidence of invasive disease due to Neisseria meningitidis is highly variable according to geographical area and serogroup distribution. Since the introduction of vaccination programs with conjugated vaccine C in children and adolescents, most cases of invasive meningococcal disease in developed countries have been caused by meningococcus B. It is important to underline that invasive meningococcal disease will not be controlled until safe and effective vaccines for meningococcal B are available and widely used. The aims of this article are to describe the most recent developments in meningococcal B vaccines and to discuss how these vaccines can contribute to containing meningococcal disease.
DermaVir: a plasmid DNA-based nanomedicine therapeutic vaccine for the treatment of HIV/AIDS

The HIV global pandemic continues to rage with over 33 million people living with the disease. Although multidrug therapy has improved the prognosis for those infected by the virus, it has not eradicated the infection. Immunological therapies, including therapeutic vaccines, are needed to supplement drug therapy in the search for a ‘functional cure’ for HIV. DermaVir (Genetic Immunity Kft, Budapest, Hungary and McLean, Virginia, USA), an experimental HIV/AIDS therapeutic vaccine, combines three key elements of rational therapeutic vaccine design: a single plasmid DNA (pDNA) immunogen expressing 15 HIV antigens, a synthetic pDNA nanomedicine formulation and a dendritic cell-targeting topical-vaccine administration. DermaVir’s novel mechanism of action, natural transport by epidermal Langerhans cells to the lymph nodes to express the pDNA-encoded HIV antigens and induce precursor/memory T cells with high proliferation capacity, has been consistently demonstrated in mouse, rabbit, primate and human subjects. Safety, immunogenicity and preliminary efficacy of DermaVir have been clinically demonstrated in HIV-infected human subjects. The DermaVir technology platform for dendritic cell-based therapeutic vaccination might offer a new treatment paradigm for cancer and infectious diseases.
Mycobacterium tuberculosis infection presenting with cutaneous abscess and osteomyelitis.

Background: Mycobacterium tuberculosis is a multi-systemic infection. A resurgence of cases of M. tuberculosis infection and extrapulmonary involvement has occurred in parallel with the HIV epidemic. Tuberculosis is rarely associated with cutaneous or osteoarticular infection. Patient: In this case report we described an unusual case of tuberculosis presenting with concurrent cutaneous abscess and osteomyelitis. The final diagnosis was confirmed by radiographic and cultural findings. Conclusion: Cutaneous tuberculosis should be included in the differential diagnosis of patients with cutaneous abscesses or musculoskeletal complaints, particularly in high risk populations such as immigrants from endemic regions and immunosuppressed patients.
Spondylodiscitis: a rare differential diagnosis of abdominal pain

Spondylodiscitis is an inflammatory process, often of infectious origin, that attacks the intervertebral disks and related vertebra. Diagnosis may be very difficult because it is a rare disease of insidious symptoms and also because of the high incidence of backache in the general. This report describes the case of a patient admitted to the Gastroenterology service with a complaint of abdominal and lumbar pain followed by progressive weight loss. Propaedeutics used had fundamental importance in the diagnosis and elimination of other causes. Conservative treatment was enough to achieve patient recovery.
Aflunov®: a prepandemic influenza vaccine

Influenza viruses are adept in human populations. Indeed, they have the capacity to evade the immune system through mechanisms of mutations (antigenic drift) and major variations in surface protein expression (antigenic shift). When a major change occurs, the risk of a human pandemic arises. Three influenza pandemics occurred during the 20th century, the most serious being the Spanish influenza. The last pandemic of the past century occurred in 1968, and the responsible virus infected an estimated 1–3 million people throughout the world. The first pandemic of the present century occurred in 2009 and was sustained by a H1N1 strain (A/California/07/09). In 1997, a novel avian influenza virus, H5N1, first infected humans in China. Since its emergence, the H5N1 virus has spread from Asia to Europe and Africa, resulting in the infection of millions of poultry and wild birds. So far, 522 human cases and 322 deaths have been reported by the WHO. Many studies have therefore been performed to obtain efficacious and safe H5N1 vaccines. One of these is Aflunov®. Aflunov is a prepandemic monovalent A/H5N1 influenza vaccine adjuvanted with MF59 produced by Novartis Vaccines and Diagnostics. In nonclinical studies conducted in rabbits, Aflunov proved to be well-tolerated, did not cause maternal or embryo–fetal toxicity, was not teratogenic, and had no effects on postnatal development. In clinical studies, Aflunov proved safe and well-tolerated in infants, children, adolescents, adults and the elderly. In the same subjects, the vaccine elicited robust immunogenicity against both homologous (A/Vietnam/1194/2004 clade 1) and heterologous viral strains (for instance, A/Indonesia/05/2005 or A/Turkey/15/2006) and induced immunologic memory. Thus, in 2010, the CHMP issued a positive opinion on Aflunov and in January 2011 Aflunov was given marketing authorization. This vaccine could be very useful in the event of adaptation of the H5N1 virus to humans, which could cause a new pandemic.
Trends in vaccine adjuvants

Adjuvants are essential components of most clinically used vaccines. This is because the majority of nonliving vaccines are relatively poor inducers of adaptive immunity unless effective adjuvants are co-administered. Aluminum salts (alum) have been used as adjuvants with great success for almost a century and have been particularly effective at promoting protective humoral immunity. However, alum is not optimally effective for diseases where cell-mediated immunity is required for protection. Furthermore, adjuvants including oil-in-water emulsions have shown improved efficacy for avian influenza protection suggesting that even for diseases where humoral immunity can confer protection, there is scope for developing improved adjuvants. There have been major developments in antigen discovery over the past decade, which has accelerated the vaccine development process for new indications and this demands a new generation of adjuvants that can drive and specifically direct the desired immune responses. A number of systems are under investigation that combine different types of adjuvants into specific formulations with greater activity. Additionally, targeting of vaccines to specific immune cells shows great promise. In the case of cancer and chronic infectious diseases, it may be difficult to develop effective vaccines without blocking immune regulatory pathways, which impede cell-mediated responses. However, increased understanding of immunology and particularly the innate immune system is informing vaccine adjuvant research and consequently driving the development of novel and specifically directed vaccine adjuvant strategies. In this article we address the importance of adjuvants in vaccine development, the known mode of action of specific adjuvants and recent developments in this important field.
Emerging vector-borne flavivirus diseases: are vaccines the solution?

The past 30 years has seen a dramatic global increase in human disease caused by flaviviruses. There are approximately 60 members of the genus Flavivirus belonging to three epidemiologically distinct groups; the mosquito-borne, the tickborne and the unknown vector viruses [1]. The most important group causing human and animal disease is the mosquito-borne viruses, which include 21 viral species. Of these, the dengue fever (DF), yellow fever (YF), Japanese encephalitis (JE) and West Nile (WN) viruses are globally the most important; all are zoonoses associated with increased epidemic activity and geographic spread.
Discovering Credible Events in Near Real Time from Social Media Streams

My proposed research addresses fundamental deficiencies in social media-based event detection by discovering high-impact moments and evaluating their credibility rapidly. Results from my preliminary work demonstrate one can discover compelling moments by leveraging machine learning to characterize and detect bursts in keyword usage. Though this early work focused primarily on language-agnostic discovery in sporting events, it also showed promising results in adapting this work to earthquake detection. My dissertation will extend this research by adapting models to other types of high-impact events, exploring events with different temporal granularities, and finding methods to connect contextually related events into timelines. To ensure applicability of this research, I will also port these event discovery algorithms to stream processing platforms and evaluate their performance in the real-time context. To address issues of trust, my dissertation will also include developing algorithms that integrate the vast array of social media features to evaluate information credibility in near real time. Such features include structural signatures of information dissemination, the location from which a social media message was posted relative to the location of the event it describes, and metadata from related multimedia (e.g., pictures and video) shared about the event. My preliminary work also suggests methods that could be applied to social networks for stimulating trustworthy behavior and enhancing information quality. Contributions from my dissertation will primarily be practical algorithms for discovering events from various social media streams and algorithms for evaluating and enhancing the credibility of these events in near real time.
Diversity and Novelty on the Web: Search, Recommendation, and Data Streaming Aspects

This tutorial aims to provide a unifying account of current research on diversity and novelty in different web information systems. In particular, the tutorial will cover the motivations, as well as the most established approaches for producing and evaluating diverse results in search engines, recommender systems, and data streams, all within the context of the World Wide Web. By contrasting the state-of-the-art in these multiple domains, this tutorial aims to derive a common understanding of the diversification problem and the existing solutions, their commonalities and differences, as a means to foster new research directions.
Effect of a behavioral intervention on male involvement in birth preparedness in a rural community in Northern Nigerian

Introduction: Delays in care seeking for obstetric emergencies are major determinants of maternal death in Nigeria. Birth preparedness has been found to be effective in reducing these delays. Male involvement is necessary for improving birth preparedness because of patriarchy which allows men to control women′s access to and utilization of maternal health care. Aim: To assess the effect of a health promotion intervention on male involvement in birth preparedness in a rural community in northern Nigeria. Materials and Method: A quasi-experimental study in which 205 and 206 married men were enrolled into study and control groups respectively. Pre-intervention, data were collected from both groups. Thereafter, a three-component health promotion intervention was carried out among the study group. Six months after, a post-intervention survey was carried out among both groups. Quantitative data was analyzed using SPSS Statistics 17.0, and statistical significance of difference between pre- and post-intervention levels of birth preparedness was determined using Chi-square test at P < 0.05. Qualitative data was analyzed manually according to themes. Results: Post-intervention, both study and control groups did not show statistically significant increase in the practice of birth preparedness. Analysis of qualitative data revealed that their religious beliefs were not in favour of the practice of birth preparedness. Conclusion: The intervention did not increase male involvement in birth preparedness likely due to religious misconceptions. Therefore, future studies should consider assessing the effect of interventions that employ religious approaches on birth preparedness.
Comparative Analysis of Screening Results from Various ELISA Formats Used for Detection of Anti-Erythropoietin Antibodies in Korean Patients

Abstract － Clinical cases of pure red cell aplasia (PRCA) have been reported during the recombinant human erythropoietin (EPO) therapy for the anemia patients. PRCA is a rare hematological disorder leading to a severe anemia due to an almost complete stop of red blood cell production. Antibody (Ab)-associated PRCA is caused by the EPO-neutralizing Abs that eliminate the biological activity of EPO. In order to detect anti-EPO Abs in human sera, we performed conventional ELISA, directly coated bridging ELISA, and streptavidin coated bridging ELISA, and compared their sensitivity and specificity. Some false positive results were obtained in the conventional ELISA. One positive sample was detected successfully by streptavidin coated bridging ELISA, which was not appeared in the directly coated bridging ELISA. In conclusion, streptavidin coated bridging ELISA was substantially sensitive and specific format and one out of sixty-eight serum samples was proved to be anti-EPO positive.Keywords: Erythropoietin, Pure red-cell aplasia, Bridging ELISA, Immunogenicity
National mental health registry for schizophrenia in Malaysia: A preliminary assessment on service utilization

The National Mental Health Registry for Schizophrenia (NMHRS) was established in Malaysia in 2003. Data includes patients who are now receiving treatment in all different facilities in the country and at all levels, including primary care. A subset of data from the registry was analyzed to assess how people with schizophrenia in Malaysia utilize the service. A total of 276 patients with schizophrenia from the NMHRS who were still being followed up after 1 year of treatment at the same facility were included in the assessment. About 13% (n=36) of the patients were seen at an emergency department, 17% (n=46) had psychiatric rehospitalization, 2% (n=6) were transferred to a mental institution, 89.1% (n=246) were on regular follow‐up, 3% (n=9) abused a substance, 22% (n=6) attempted self harm, 4% (n=10) had been in contact with or arrested by police, 10% (n=27) utilized community mental health services and 14% (n=38) continued to seek alternative treatment. Apart from being useful in assisting policy planners, administrators, and clinicians to further improve the mental health services, the present study can also suggest areas of future service research for people with schizophrenia in Malaysia.
Virus-like particle-based vaccines against hepatitis C virus infection

HCV infection is a worldwide health problem and much effort is being made to develop novel therapies. New vaccines are designed for preventive and therapeutic use through induction of robust immunity, including neutralizing antibodies and T-cell-mediated immunity. Novel future vaccine approaches include virus-like particle (VLP)-based vaccines that have been successfully employed to prevent infections by hepatitis B virus or human papillomavirus. The HCV-derived VLP approach simplifies the delivery of neutralizing antibody- and core-specific T-cell epitopes in a highly immunogenic single construct resembling mature HCV virions. The size, particulate nature and dense, repetitive structure of VLPs are the basis for their innate immunogenicity. Consequently, VLPs have also been exploited as antigenic platforms. Association of HCV antigens with heterologous structural viral proteins able to form recombinant VLPs (HBsAg, HBcAg, MLV Gag, PapMV coat protein) is also a promising approach for induction of HCV-specific immune responses. This article summarizes the different VLP-based vaccine approaches that are currently under development.