Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation of Computed Tomography Test Bolus Dynamics and Conventional Computed Tomography Parameters With Pulmonary Vascular Resistance in Patients With Pulmonary Arterial Hypertension

Objective: Pulmonary vascular resistance (PVR) is a measurement obtained with invasive right heart catheterization (RHC) that is commonly used for management of patients with pulmonary arterial hypertension (PAH). Computed tomography pulmonary angiography (CTPA) is also done as part of the workup for PAH in some cases. The aim of our study was to assess the correlation of contrast dynamic changes in the main pulmonary artery (MPA) on CTPA with PVR obtained with RHC. Methods: This is an IRB-approved retrospective study performed in two separate institutions (Medical College of Wisconsin and University of Alabama) between January 2010 and December 2013. During CTPA done as test bolus, serial images are acquired at the level of MPA after intravenous injection of contrast to determine timing of the CT acquisition. Since the PVR changes with the degree of PAH, we hypothesize that will be reflected in the contrast kinetics in MPA. A correlation of standard CT metrics (MPA diameter, right pulmonary artery [PA] diameter, left PA diameter, MPA/aorta ratio, and right ventricle/left ventricle [RV/LV] ratio) and dynamic (full width at half maximum) CTPA parameters in patients with known PAH was performed with PVR obtained from RHC done within 30 days. Statistical analysis was performed by Pearson correlation coefficient. Results: Among 221 patients in our database, 37 patients fulfilled the selection criteria. There was a strong correlation between full width half maximum (FWHM) and mean pulmonary artery pressure (mPAP) (r=0.69, p value<0.00001), PVR (r=0.8, p value<0.00001) and indexed PVR (PVRI) (r=0.75, p value<0.00001). Conclusion: FWHM obtained from CTPA strongly correlates with RHC parameters and is potentially more helpful than static measurements for follow-up of patients with known PAH to assess response to treatment or progression.
Policy preferences in response to negative economic prospects of COVID‐19: A survey‐experiment among local politicians in four European countries

Abstract This study investigates how the negative economic prospects of the COVID‐19 pandemic affect local government politicians' policy preferences in the Netherlands, the United Kingdom, Switzerland, and Spain. The study examines to what extent politicians prefer increasing the role of government (directive state), transferring public tasks to private sector organizations (hollow state), transferring public tasks to third sector organizations (communitarian state), or downsizing and reducing the role of government without transferring tasks (coping state). The experiment primes decision‐makers on the pandemic's negative financial and economic prospects vis‐à‐vis its impact on health and well‐being. When negative economic prospects are emphasized, the study finds decreased preferences for a directive state and increased preferences for a coping state. The study concludes that how decision‐makers interpret the nature of a crisis determines their preferred response: An emphasis on the negative economic prospects of the COVID‐19 pandemic is likely to increase preferences for renewed policies of austerity.
To what extent are conspiracy theorists concerned for self versus others? A COVID‐19 test case

Abstract We examined whether people who are prone to believe COVID‐19 conspiracy theories are characterised by an especially strong concern for others or an especially strong concern for the self, and whether these orientations are associated with willingness to take a COVID‐19 vaccine. We surveyed 4,245 participants from eight nations; three months later we re‐contacted 1,262 participants from three nations. Belief in COVID‐19 conspiracy theories was related to greater concerns about one's own safety, and lower concerns about the safety of close others. Furthermore, conspiracist ideation at Wave 1 predicted reluctance to take a COVID‐19 vaccine at Wave 2, mediated through relative concern for self versus others. In sum, people who are high in conspiracy beliefs have relatively higher concern for the self relative to others, with troubling implications for public health.
Withdrawal of Inhaled Corticosteroids in Patients with COPD – A Prospective Observational Study

Background Inhaled corticosteroids (ICS) are widely used in the treatment of chronic obstructive pulmonary disease (COPD), but recent studies have raised doubts whether all COPD patients will benefit from ICS. This study evaluates in a real-life setting the effects of ICS withdrawal in patients with COPD. Methods The study was a prospective intervention study following patients with COPD for 6 months after abrupt withdrawal of ICS. FEV1 (L), blood eosinophilic count (x10E9/L) and number of exacerbations were measured at baseline, 1, 3 and 6 months after ICS withdrawal. Results Ninety-six patients (56 females (57.4%), mean age 70 years (51–94 years)) with COPD were included in the study. Eleven patients were excluded during the study period (7 patients died, 4 patients withdrew their consent during the study period). During the 6 months, 51 patients (60%) had resumed treatment with ICS, of whom 34 patients (68%) experienced an exacerbation during follow-up. No significant decline in FEV1 was seen in this group between baseline and after 6 months (ΔFEV1 0.07 L, p = 0.09). In the remaining 34 patients (40%) without ICS after 6 months of follow-up, 15 patients (44.1%) experienced an exacerbation. No significant decline was seen in FEV1 at baseline and after 6 months (ΔFEV1 0.04 L, p = 0.28). There were no statistically significant differences between the two groups in age (70.5 vs 69.6 years, p = 0.53), nor between FEV1 at baseline (0.96 L vs 1.00 L, p = 0.63) or eosinophilic count (0.25 x10E9/L vs 0.17 x10E9/L, p = 0.07). Conclusion Abrupt withdrawal of ICS was possible in some patients. However, more than half of the patients resumed ICS during follow-up. Based on results from our study we were not able to foresee – from neither history of exacerbations nor eosinophilic count – whom will be able to manage without ICS and who will resume treatment with ICS.
Injury Rates in Major League Baseball During the 2020 COVID-19 Season

Background: The 2020 Major League Baseball (MLB) season was drastically altered because of the COVID-19 pandemic. The changes included an extended layoff between March and July as well as a shortened preseason. Purpose/Hypothesis: To determine the incidence and epidemiology of MLB injuries in the abbreviated 2020 season compared with prior seasons. We hypothesized that there was an increase in the overall injury rate in the 2020 season compared with the 2018-2019 seasons and that it equally affected all body regions. Study Design: Descriptive epidemiology study. Methods: The MLB transactions database was queried to find players who had been placed on the injury list between 2018 and 2020. Injuries were categorized into upper extremity, lower extremity, spine/core, and other injuries. Incidence per 1000 athlete-exposures was calculated for the prior 2 seasons (2018-2019) and for the 2020 season separately. Incidence for each category was also calculated separately for pitchers and fielders. Incidence rate ratios (IRRs) and confidence intervals were used to compare injury rates in 2018-2019 versus 2020. The z test for proportions was used to determine significant differences between injury incidences. Results: In 2020, the overall incidence rate per 1000 athlete-exposures was almost twice the rate compared with the 2 seasons before COVID-19 (8.66 vs 5.13; IRR, 1.69 [95% CI, 1.53-1.87]; P < .001). Injury incidence increased similarly in 2020 for both pitchers (IRR, 1.68 [95% CI, 1.47-1.91]; P < .001) and fielders (IRR, 1.68 [95% CI, 1.45-1.96]; P < .001). Increases in injury incidence were seen in the upper extremity, spine/core, and other injury categories; however, the incidence of the lower extremity did not change significantly. Conclusion: There was a significant increase in injury incidence for both pitchers and fielders in 2020. Injury rates increased in anatomic zones of the upper extremity and spine/core but were not significantly changed in the lower extremity. The overall increase in injury rate suggests that irregular or insufficient sport-specific preparation prior to the start of the season placed athletes at a greater risk of injury when play resumed.
Epoxy-montmorillonite clay nanocomposites: Synthesis and characterization

Nanocomposites of epoxy resin with montmorillonite clay were synthesized by swelling of different proportions of the clay in a diglycidyl ether of bisphenol-A followed by in situ polymerization with aromatic diamine as a curing agent. The montmorillonite was modified with octadecylamine and made organophilic. The organoclay was found to be intercalated easily by incorporation of the epoxy precursor and the clay galleries were simultaneously expanded. However, Na-montmorillonite clay could not be intercalated during the mixing or through the curing process. Curing temperature was found to provide a balance between the reaction rate of the epoxy precursor and the diffusion rate of the curing agent into the clay galleries. The cure kinetics were studied by differential scanning calorimetry. The exfoliation behavior of the organoclay system was investigated by X-ray diffraction. Thermogravimetric analysis was used to determine the thermal stability, which was correlated with the ionic exchange between the organic species and the silicate layers. The morphology of the nanocomposites was evaluated by scanning electron microscopy. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 2201–2210, 2004
Prediction of out-of-pocket health expenditures in Rwanda using machine learning techniques

Introduction in Rwanda, the estimated out-of-pocket health expenditure has been increased from 24.46% in 2000 to 26% in 2015. Despite the existence of guideline in estimation of out-of-pocket health expenditures provided by WHO (2018), the estimation of out-of-pocket health expenditure still have difficulties in many countries including Rwanda. Methods the purpose of this paper was to figure out the best model which predicts the out-of-pocket health expenditures in Rwanda during the process of considering various techniques of machine learning by using the Rwanda Integrated Living Conditions Surveys (EICV5) of 14580 households (2018). Results our findings presented the model which predict the out-of-pocket health expenditures with higher accuracy and was found as treenet model. Furthermore, machine learning techniques were used to judge which predictor variable was important in our prediction process and comparison of the performance of the algorithms through train accuracy and test accuracy metric measures. Finally, the findings show that the tests of accuracy of the models were 50.16% for multivariate adaptive regression splines (MARS) model, 74% decision tree model, 87% for treenet model, 83% for random forest model, gradient boosting 81%, predictor total consumption played a significant role in the model for all tested models. Conclusion finally, we conclude that the total consumption of the household came out to be the most important variable which is consistently true to all the algorithms tested. The findings from our study have policy implications for policy makers in Rwanda and in the world generally. We recommend the government to significantly increase public spending on health. Domestic financial resources are key to moving closer to universal health coverage (UHC) and should be increased on a long-term basis. In addition, these results will be useful for the future to assess the out-of-pocket health expenditures dataset.
The complete chloroplast genome of Securigera varia (L.) Lassen

Abstract Securigera varia is an important leguminous forage grass species that is mainly distributed in arid and semi-arid land with water scarcity, and has outstanding drought resistance. In this study, Illumina sequencing was used to obtain the complete sequence of the S. varia chloroplast genome. The complete genome was 154,257 bp in length with 35.9% GC content. It was a circular genome containing a large single-copy region (LSC, 84,762 bp), a small single-copy region (SSC, 18,059 bp), and a pair of inverted repeat regions (IRs, 51,436 bp). A total of 128 genes were encoded, including 83 protein-coding genes, 37 tRNAs, and 8 rRNAs. Phylogenetic analysis revealed that S. varia was closely related to Robinia pseudoacacia. The sequence data of S. varia chloroplast genome could provide useful genetic information for the studies on phylogenetic and evolutionary of Leguminosae.
The complete chloroplast genome sequences of Cornus elliptica (Cornaceae)

Abstract Cornus elliptica is a species of the Cornus, an evergreen tree endemic to China. Here, we report a complete chloroplast genome sequence of C. elliptica. The chloroplast genome was found to be 157,400bp in length, and G-C contents were 38.1%. The sequence contained 115 unique genes, including 31 tRNA, 4 rRNA, and 80 protein-coding genes. Phylogenetic framework of Cornus is consistent with previous studies.
Effects of Different Ambient Temperatures on Caecal Microbial Composition in Broilers

Abstract Short-term or acute temperature stress affect the immune responses and alters the gut microbiota of broilers, but the influences of long-term temperature stress on stress biomarkers and the intestinal microbiota remains largely unknown. Therefore, we examined the effect of three long-term ambient temperatures (high (HC), medium (MC), and low (LC) temperature groups) on the gene expression of broilers’ heat shock proteins (Hsps) and inflammation – related genes, as well as the caecal microbial composition. The results revealed that Hsp70 and Hsp90 levels in HC group significantly increased, and levels of Hsp70, Hsp90, IL-6, TNF-α, and NFKB1 in LC group were significantly higher than in MC group (p < 0.05). In comparison with the MC group, the proportion of Firmicutes increased in HC and LC groups, while that of Bacteroidetes decreased in LC group at phylum level (p < 0.05). At genus level, the proportion of Escherichia/Shigella, Phascolarctobacterium, Parabacteroides,and Enterococcus increased in HC group; the fraction of Faecalibacterium was higher in LC group; and the percentage of Barnesiella and Alistipes decreased in both HC and LC groups (p < 0.05). Functional analysis based on communities’ phylogenetic investigation revealed that the pathways involved in environmental information processing and metabolism were enriched in the HC group. Those involved in cellular processes and signaling, metabolism, and gene regulation were enriched in LC group. Hence, we conclude that the long-term temperature stress can greatly alter the intestinal microbial communities in broilers and may further affect the host’s immunity and health.
Infection palustre de la femme enceinte à Niamey au Niger

Introduction le paludisme chez la femme enceinte est un problème majeur de santé publique en Afrique. Il a des conséquences graves aussi bien sur la mère, le fœtus que le nouveau-né. Il est responsable d´un fort taux de morbi-mortalité maternelle et infantile. L´objectif de l´étude est de déterminer la prévalence de l´infection plasmodiale chez la femme enceinte, décrire ses signes cliniques et ses complications éventuelles, analyser les facteurs associés et proposer des mesures de prévention. Méthodes il s´agit d´une étude transversale, conduite du 1er juin au 30 novembre 2017 à la Maternité Issaka Gazobi (MIG) de Niamey. Le diagnostic a été fait par microscopie. Résultats deux cents quarante-neuf (249) femmes ont été incluses dans cette étude. La prévalence de l´infection plasmodiale était de 36,5% (IC95%; [30,6; 42,9]). La densité parasitaire moyenne était de 177 P/μl (DS: 121; [40; 800]). Toutes les infections étaient à P. falciparum. Un peu plus de soixante-treize pourcent (73,6%). Seules 26,4% (24/91) ont fait un paludisme non compliqué ; 9,6% (6/91) ont avorté ; 38,4% des nouveau-nés avaient un faible poids à la naissance et 26,51% (66/249) ont développé un paludisme congénital. Le taux de létalité était de 1,1% (1/91). Le traitement préventif intermittent (TPI) protège significativement contre le paludisme gestationnel (p=0,01). Conclusion l´infection des femmes enceintes par le P. falciparum est très fréquente au Niger. Ce portage est le plus souvent asymptomatique mais peut évoluer vers un paludisme non compliqué ou même sévère. Les principales conséquences sont l´avortement, le faible poids à la naissance, le retard de croissance intra utero, le paludisme congénital et le décès maternel. Le TPI et l´utilisation de la moustiquaire imprégnée d´insecticide à longue durée d´action (MILDA) permettent de prévenir l´infection.
Tumor regression and immunity in combination therapy with anti-CEA chimeric antigen receptor T cells and anti-CEA-IL2 immunocytokine

ABSTRACT Targeted immunotherapy of solid cancers with chimeric antigen receptor (CAR) T cells and immunocytokines are attractive options in that they both rely on the specificity of tumor-targeted antibodies. Since carcinoembryonic antigen (CEA) expression in both colon and breast cancers is correlated with poor prognosis, it was chosen as a model tumor target in immunocompetent CEA transgenic (CEATg) mice. A second-generation anti-CEA CAR derived from CEA-specific antibody T84.66 was used to treat murine MC38 colon or E0771 breast carcinomas transfected with CEA. Anti-CEA CAR vs. mock transduced T cells exhibited a CEA-specific cytotoxic and IFN$$\gamma $$γ dose response to both CEA transfected cell lines vs. their CEA-negative controls. Anti-CEA CAR vs. mock transduced T cells delayed the median survival of CEA transfected s.c. MC38 or orthotopic E0771 tumor-bearing CEATg mice by 2 days. With the addition of one-day prior cyclophosphamide (CY) lymphodepletion, anti-CEA CAR T cell treatment delayed the median survival of MC38/CEA and E0771/CEA tumor-bearing CEATg mice by ten and 3 days, respectively. Since CAR T cells require IL2 for survival and expansion, anti-CEA-IL2 immunocytokine (ICK) treatment was performed post CAR T cell therapy. Single ICK treatment 1 day after CY plus anti-CEA CAR T cell therapy in the MC38/CEA model, and two ICK treatments every 3 days after CY plus anti-CEA CAR T cell therapy in the E0771/CEA model were ineffective, while four ICK treatments every 3 days after CY plus anti-CEA CAR T cell therapy completely eradicated MC38/CEA tumor growth and induced tumor immunity when the mice were re-challenged with tumor. These studies show the therapeutic potential of anti-CEA CAR T cells combined with ICK to treat CEA-positive tumors. Abbreviations: CAR: Chimeric antigen receptor, CEA: Carcinoembryonic antigen, CEACAM5, ICK: Immunocytokine, CY: Cyclophosphamide, CEATg mouse: transgenic CEA mouse, TDLN: Tumor-draining lymph node
Compassionate goals, prosocial emotions, and prosocial behaviours during the COVID‐19 pandemic

Abstract During the COVID‐19 pandemic, it is important for people to engage in prosocial behaviours to support one another. The aim of this research is to answer a key question: in a social crisis, what motivates Americans to help others? Guided by research on appraisal theories and ecosystem theory, we examined the role of compassionate goals and prosocial emotions in promoting prosocial behaviours towards either out‐group or in‐group members. Study 1 (N = 943) was conducted in February 2020, before the widespread transmission of COVID‐19 began in the United States. Results show that people with high compassionate goals are more likely to experience sympathy, which in turn makes them more willing to help people suffering from COVID‐19 in China. Study 2 (N = 1,009) was conducted with a nationally representative sample after COVID‐19 became more prevalent in the United States. Although people with high compassionate goals still experience more sympathy and solidarity, sympathy does not predict donation intention. Instead, solidarity mediates the relationship between compassionate goals and donation intention. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
A species-specific triplex PCR assay for authentication of Galli Gigerii Endothelium Corneum

Abstract A triplex PCR assay was developed to identify animal species and adulteration of a natural medicine Galli Gigerii Endothelium Corneum (GGEC). Three species-specific primer sets were designed according to the difference in mitochondrial genome of Gallus gallus domesticus, Anas platyrhynchos and Anser anse. The PCR conditions were optimized and the assay was well validated for high specificity and sensitivity (1 mg/μL). Especially, when artificial adulterants made from the mixture of three species were analyzed, the assay has still exhibited strong capability of differentiation. By using this developed method, two batches out of fourteen commercial GGEC products were identified to be adulterated by Anser anse. The newly proposed assay showed sufficient merits as a regular tool for the identification of counterfeits or adulterants of GGEC product for their pulverized and processed form, and even Chinese patent medicines composed of these species.
The Synthesis and Characterization of New Cross- Linkable Quinolone and Quinoline-Based Luminescent Lanthanide Chelates

Luminescent lanthanide probes possess long emission lifetime, which enables their hypersensitive detection in time- resolved mode that avoids short-lived background fluorescence. Sharply spiked emission spectra of lanthanide probes and large Stokes shifts further enhance detection sensitivity, which is about 1000 fold higher than that for regular fluorescent probes. The wide spread of this promising technology is limited by high cost of commercially available compounds, which is mainly due to their complex structure and laborious synthetic procedure. In this study, new efficient strategies to simplify the synthesis of the probes were explored. New lanthanide chelates, containing click-, and amine-reactive cross-linking groups, which are highly bright and can be produced with high yield, are synthesized and characterized.
A space vector PWM method for three-level flying-capacitor inverters

This paper presents a new space vector PWM method for a 3-level flying-capacitor inverter. In the proposed technique, boundary restrictions can be easily incorporated to minimize the harmonic distortion of the output voltages. Simple algebraic equations are used to calculate the pulse widths of the gate signals from the sampled reference voltages. This feature make easy the implementation in real time. The voltages on the flying capacitors are regulated by simple ON-OFF controllers independently of the output voltage control. The main features of the proposed technique are analyzed by computer simulations. The experimental tests obtained confirm the expected results.