Miracle-dz/UniFAR-FTUs huggingface dataset:
Career anchors and preferences for organizational career management: a study of information technology professionals in three European countries

Abstract Careers research has moved beyond the notion of traditional careers in a stable, predictable work environment to a more individual perspective. However, individual agency in career management is still likely to involve interactions between organizations and individuals. This is particularly evident in organizational career management (OCM). Career anchor theory has shed light on the work preferences of professionals but little research has examined relationships between career anchors and how people enact their careers, or how these constructs and their relationships might differ between countries. We report a quantitative study of 1629 IT professionals from 10 organizations in Switzerland, Germany and the UK. After allowing for control variables, career anchor scores explained statistically significant amounts of variance in preferences for five of the six categories of OCM practices. Some of the connections between career anchors and OCM preferences followed naturally from their content, but others were less self-evident, or even seemingly contradictory. There were some significant differences between nationalities, with the UK tending to be the outlier. These differences were partly but not entirely consistent with prior research. This study expands understanding of the interplay of individual values and OCM and draws on previous work to offer a new classification of OCM practices.
Most Enterobacter aerogenes Strains in France Belong to a Prevalent Clone

ABSTRACT The aim of this study was to determine the distribution in France of the Enterobacter aerogenes prevalent clone isolated in the hospitals of the Marseille area (A. Davin-Regli, D. Monnet, P. Saux, C. Bosi, R. Charrel, A. Barthelemy, and C. Bollet, J. Clin. Microbiol. 34:1474–1480, 1996). A total of 123 E. aerogenes isolates were collected from 23 hospital laboratories and analyzed by random amplification of polymorphic DNA and enterobacterial repetitive intergenic consensus-PCR to determine their epidemiological relatedness. Molecular typing revealed that 21 of the 23 laboratories had isolated this prevalent clone harboring the plasmid encoding for extended-spectrum β-lactamase of the TEM-24 type. Most isolates were susceptible only to imipenem and gentamicin. Their dissemination seems to be clonal and was probably the result of the general use of broad-spectrum cephalosporins and quinolones. Four isolates showed an alteration of their outer membrane proteins, causing decrease of susceptibility to third-generation cephalosporins and imipenem and leading to the critical situation of having no alternative therapeutic. The large dissemination of the E. aerogenesprevalent clone probably results from its good adaptation to the antibiotics administered in France and the hospital environment, particularly in intensive care units.
Physiological Importance of Deficiency in Early Prandial Insulin Secretion in Non-Insulin-Dependent Diabetes

Patients with non-insulin-dependent diabetes mellitus (NIDDM) have a deficiency in early prandial insulin secretion. To determine the contribution of this early deficiency to prandial hyperglycemia, exogenous intravenous insulin (1.8 U over 30 min) was delivered to eight NIDDM subjects in a profile designed to simulate the normal initial rise in insulin levels. The same dose of insulin was also administered 1) in the same profile but delayed by 30 min and 2) as a constant infusion over 180 min. Augmentation of the early insulin response caused a 33 ± 4% reduction in the glycemic response to a mixed meal (P < .005); the peak blood glucose increment above baseline was reduced by 1.4 mM (P < .005) to an increment identical to nondiabetic subjects (3.3 ± 0.3 vs. 3.2 ± 0.2 mM), and blood glucose levels were still 0.9 mM lower after 180 min (P < .05). In contrast, the delayed profile or constant infusion did not significantly alter the glycemic response to the meal. Early insulin augmentation resulted in elevated peripheral insulin levels initially (peak level 81 ± 11 mU/L), but subsequent insulin and C-peptide levels were lower than in the control study (at 180 min after the meal, 22 ± 5 vs. 33 ± 8 mU/L, P < .05, and 4.0 ± 0.5 vs. 5.3 ± 0.6 μg/L, P < .02, respectively). Early insulin delivery caused free-fatty acid (FFA) levels to fall at a faster rate after the meal and also attenuated the initial rise in glucagon levels typical of NIDDM. We conclude that the deficiency in early prandial insulin secretion contributes to prandial hyperglycemia and late hyperinsulinemia and may be partially responsible for the abnormal FFA and glucagon responses in NIDDM.
Management of Sharia Corporate Social Responsibility (CSR) as a Community Establishment for Civil Society

: The purpose of this paper is: 1. Todescriibe and crictically evaluate the concept of civil society from expert 2. To explain about the management of Corporate Social Responsibility (CSR) Islamic companies 3. To make a model of sharia corporate social responsibility for the establishment of civil society. In this research the author uses literature study method (Research library) and interview from the expert.The conclusions of the research are: 1. The concept of civil society is actually an Islamic-styleconcept of civilizationthat lays the principles of the basic values of aharmonious and balanced society. 2. Islamic CSR Management is a management basedonthe fulfillment of rights that include the fulfillment of religious rights, the right to get an education, the right to obtain health, offspring, and the right to get justice and prosperity economically which in its management there are no conflicting elements with the Islamic law. 3. Proper management of CSR can certainly strengthen or increase the accumulation of social capital in order to improve the welfare of the community. Contribution result of this research is significant for the sharia marketing science Implication from this research is for the society and the sharia companies and conventional companies whos want to do the sharia corporate social responsibility. Lack of the previous research is still there is no much research about sharia corporate corporate social responsibility that linked with civil society establisation.
Alcohol Consumption of Patients Attending Two Accident and Emergency Departments in North-West England

The impact of alcohol use on the workload of two accident & emergency departments in north-west England was assessed by blood alcohol concentration (BAC) measurement, inspection of clinical records and interview of all patients aged 16 and over attending throughout a two-week period. The frequency of intoxication was similar to the previous reported rate in Scotland: 13.2% of all patients had a positive BAC. Inebriated injured patients arrived at all times of the day — varying in frequency from 2.5% of midday attenders to 78% of those presenting after midnight. The incidence of alcohol-related industrial accidents was low, but 60% of all assaulted patients were inebriated, many having sustained head injuries. Of patients attending within 2 hours of an accident at home, 19% also had a positive BAC, but 92% of those with ankle sprains were sober. Patients in lower social classes reported higher rates of alcohol consumption. The popularity of beer in comparison to wines and spirits was inversely related to age and unrelated to social class. Alcohol abuse is commonly associated with injuries sustained at home and with assaults occurring in public places. Prevention campaigns directed at the reduction of these types of incidents should be as concerned with the inebriation of the patient as with the architectural, environmental and legal framework within which the ‘accident’ occurs.
Histologic and Ultrastructural Analysis of Ultraviolet B Laser and Light Source Treatment of Leukoderma in Striae Distensae

Lasers and light sources emitting ultraviolet B (UVB) irradiation have been shown to repigment striae distensae. Objective The purpose of this study was to analyze the histologic and ultrastuctural changes seen after UVB laser– or light source–induced repigmentation of striae distensae. Methods Ten subjects with hypopigmented striae were selected. Five subjects were treated with an XeCl excimer UVB laser, and five subjects were treated with a UVB light device. Six months after the final treatment, the biopsies were evaluated for both standard and electron microscopic changes in melanocytes. Results Analyses of biopsied skin after treatment with both the UVB laser and light source showed increased melanin content, hypertrophy of melanocytes, and an increase in the number of melanocytes in all patients. Conclusions Repigmentation of striae distensae with either a UVB laser or light source is due to an increase in melanin pigment, hypertrophy of melanocytes, and an increase in melanocytes.
DeepGestalt - Identifying Rare Genetic Syndromes Using Deep Learning

Facial analysis technologies have recently measured up to the capabilities of expert clinicians in syndrome identification. To date, these technologies could only identify phenotypes of a few diseases, limiting their role in clinical settings where hundreds of diagnoses must be considered. We developed a facial analysis framework, DeepGestalt, using computer vision and deep learning algorithms, that quantifies similarities to hundreds of genetic syndromes based on unconstrained 2D images. DeepGestalt is currently trained with over 26,000 patient cases from a rapidly growing phenotype-genotype database, consisting of tens of thousands of validated clinical cases, curated through a community-driven platform. DeepGestalt currently achieves 91% top-10-accuracy in identifying over 215 different genetic syndromes and has outperformed clinical experts in three separate experiments. We suggest that this form of artificial intelligence is ready to support medical genetics in clinical and laboratory practices and will play a key role in the future of precision medicine.
The Covariance Matrix between Real Assets

For real assets such as private equity, infrastructure, and real estate, computing the time-variance of trade prices is of limited interest because there is not much trading in these assets. The author argues that it is more meaningful to use variance measures over the cross section as indicators for investment risk. In a large database of funds invested in sparsely traded assets, the cross-sectional variance—or dispersion—of fund performances is measured within and between the asset classes in which they are invested. The covariance matrix that is estimated in this way has features similar to the matrix between regularly traded assets that is computed over time. The author argues that the matrix provides a practical framework for analyzing risk and constructing portfolios invested in real assets with the same methods that are habitually employed on liquid assets.
3′,4′-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia

Objectives: In the present study, effects of 3′,4′-dihydroxyflavonol (DiOHF) on anxiety-like behavior, and learning and memory were investigated in a model of transient global cerebral ischemia and reperfusion. Methods: The animals were assigned to sham-operated, ischemia, and two DiOHF-treated (10 mg/kg i.p.) groups. DiOHF was administered at 1 hour before and immediately after the ischemia. Male rats were subjected to bilateral common carotid artery occlusion to induce acute cerebral ischemia for 20 minutes, followed by reperfusion for 7 days. The openfield, elevated plus maze (EPM), and Morris water maze tests were used to evaluate the effects of DiOHF treatment on ischemia-induced locomotor activity, anxiety-like behavior, and spatial and recognition memory impairments, respectively. Results: In the open field test, locomotor activity in the ischemic rats was not altered 6 days after the ischemia, nor was anxiety-like behavior, which was evaluated with the EPM (P > 0.05). In the water-maze test, cerebral ischemia significantly decreased the exploration time in the target quadrant, and the platform crossing counts were lower (P < 0.05) in the probe trial test; this memory impairment was significantly improved by DiOHF applied 1 hour before and immediately after ischemia (P < 0.05). Discussion: All together, these findings suggest that DiOHF reverses spatial learning and memory deficits resulting from transient global ischemia but has no significant effect on anxiety-like behavior.
Education Policy And Rate of Return Estimates (Job Market Paper)

Studies of education policy in developing countries often cite larger estimated wage returns to basic education relative to higher education (adjusted for public costs), as evidence of over-investment in higher education. These estimates have provided a justification for the shift of public funding towards basic education. This paper shows that these estimates are not reliable for education policy when productivity depends on the proportion of higher educated workers (a productivity externality), and higher educated workers are an input in the production of basic education (a human capital externality). Using data on cross-country agricultural productivity gaps, and returns to education for immigrants in the U.S. by country of origin, I show that the productivity and future human capital effects of higher educated workers are quantitatively important. The productivity and human capital effects are equal to, and in some cases greater than, the oft-cited difference between standard estimates of the public-costadjusted return to basic and higher education. The effects also decline with education levels, which is consistent with studies which find small education externalities in more advanced economies. An implication is that if the expansion in basic education is to be profitable, adequate attention must also be paid to higher education.
A novel resonant network for a WPT system with constant output voltage

The primary side series-secondary side series (SS) compensation network of a wireless power transfer system has a simple structure. But its output voltage changes with different load resistances. This limits its applications in certain circumstances need a stable output voltage. Aiming at this problem, this paper presents a novel resonant network with output voltage stability when load resistance changes. The resonant network presented in this paper is based on an LCL (inductance-capacitance-inductance) immittance converter, and is improved of the basic SS compensation network. First of all, the operational principle and the frequency characteristics of the LCL-SS resonant network are discussed. Then, output characteristics of the LCL-SS and the SS compensation network are analyzed in a simulation model, and the simulation results illustrate the advantages of the proposed resonant converter. At last, an experimental prototype, delivering 254W power to a resistive load at the distance of 15cm, is constructed based on this resonant converter. The theoretical analysis and the feasibility of the proposed method are verified by the experimental results.
Decline of serum levels of free testosterone in aging healthy Chinese men

Objective. To investigate the age-related change of serum androgen levels in healthy men and to define a cut-off value of serum testosterone for the diagnosis of androgen deficiency in the aging male. Method. 1080 healthy men aged 20 to ⩾70 years old were enrolled in Beijing, Shanghai, Xian and Chongqing. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), calculated free testosterone (cFT), sex hormone binding globulin (SHBG), 17beta-oestradiol (E2), the T/LH ratio, and T/SHBG as a free testosterone index (FTI) were all determined. Results. Serum total T did not significantly decline, but the cFT, T/LH and FTI progressively decreased with aging. To determine androgen deficiency, the 10th percentile value of men <40 years was defined as the lower cut-off value for cFT, T/LH or FTI, which were 0.3 nmol/L, 2.8 nmol/IU, and 0.4 nmol/IU respectively. With the median value of cFT of men aged between 20 and 49 years as the criterion, the level of cFT was lower in 2.82% of men from 40 to 49 years, in 19.53% from 50 to 59 years, in 22.57% from 60 to 69 years, and in 33.19% of men ⩾70 years. Taking the above value of cFT as the cut-off point, the prevalence of androgen deficiency in men 40–49 years was 13.0%, 31.8% in men 50–59 years, 30.1% in men 60 to 69 years, and 46.7% in men >70 years. Conclusions. (i). While serum total T values do not decline with aging, the levels of cFT gradually decline with aging; (ii) when using the value of cFT of the 10th percentile of men aged 20 to 39 years as the cut-off point, the prevalence of androgen deficiency was <15% before the age of 50 years, and about 30% thereafter, approaching 45% after the age of 70 years; and (iii) in this study the values of T/LH paralleled those of cFT closely; therefore, T/LH could serve as a surrogate for cFT.
Malignant dysphagia: palliation with esophageal stents--long-term results in 100 patients.

PURPOSE To evaluate the long-term palliative effect of self-expanding nitinol esophageal stents in patients with malignant dysphagia. MATERIALS AND METHODS One hundred patients with severe dysphagia secondary to malignant esophageal strictures were treated with self-expanding nitinol stents. The strictures were caused by squamous carcinoma (n = 43), adenocarcinoma (n = 28), anastomotic tumor recurrence (n = 14), and mediastinal tumor (n = 15). RESULTS One hundred six stents were successfully positioned in 100 patients. Attempts to insert a second, coaxial stent were unsuccessful in two patients; a second stent was placed incorrectly in another patient. Statistically significant (P < .001) reduction of dysphagia was noted after expansion of the stents. Complications consisted of incomplete expansion secondary to stent twisting (n = 4), stent migration (n = 4), tumor ingrowth (n = 17), tumor overgrowth (n = 3), food impaction (n = 5), fracture of stent wires (n = 2), benign strictures at stent edges (n = 2), tumor bleeding (n = 3), and esophagorespiratory fistula (n = 5). The primary patency rate was 75% (77 of 102 stents); the secondary patency rate was 94% (96 of 102 stents). The survival time (mean, 6.2 months; range, 0.1-47 months) varied with the diagnosis. CONCLUSION Placement of self-expanding nitinol stents is safe and has a good long-term palliative effect on dysphagia in patients with malignant esophageal strictures.
Adenosine Monophosphate–Activated Protein Kinase-&agr;2 Deficiency Promotes Vascular Smooth Muscle Cell Migration via S-Phase Kinase–Associated Protein 2 Upregulation and E-Cadherin Downregulation

Objective—Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are critical events in the progression of several vasculopathologies. Adenosine monophosphate–activated protein kinase (AMPK) has been shown to play a pivotal role in cellular proliferation and migration. However, the roles of AMPK in VSMC migration and its underlying molecular mechanisms remain elusive. Approach and Results—VSMC migration and the neointima formation were studied in cultured mouse VSMCs or in carotid artery ligation of wild-type C57BL/6J mice, AMPK&agr;2, AMPK&agr;1 homozygous-deficient (AMPK&agr;2−/−, AMPK&agr;1−/−) mice. Deletion of AMPK&agr;2, but not AMPK&agr;1, led to increased phosphorylation of both IкB kinase &agr; and its downstream target nuclear factor кB2/p100 at serine 866/870. Consequently, phosphor-p100 at S866/870 bound with E3 ubiquitin ligase &bgr;-transducin repeat–containing protein resulting in the proteolytic processing of the p100 precursor and nuclear factor кB2/p52 induction. Interestingly, acetylation of histone H3 at lysine 56 mediated by histone deacetylase-3 reduction was enhanced significantly in AMPK&agr;2−/− VSMCs compared with wild-type or AMPK&agr;1−/− VSMCs. Moreover, the augmented association of p52/acetylation of histone H3 at lysine 56 with the promoter of ubiquitin E3 ligase, S-phase kinase–associated protein 2, was shown in AMPK&agr;2−/− VSMCs by chromatin immunoprecipitation assay. Furthermore, AMPK&agr;2 deletion caused S-phase kinase-associated protein 2–mediated E-cadherin downregulation. S-Phase kinase–associated protein 2 siRNA abolished the increased migration of AMPK&agr;2−/− VSMCs via E-cadherin upregulation. Finally, neointima formation after ligation of carotid artery was increased in AMPK&agr;2−/−, but not AMPK&agr;1−/−, mice. Conclusions—We conclude that deletion of AMPK&agr;2 causes aberrant VSMC migration with accelerated neointima formation in vivo.
Why Do Firms Bundle Earnings and Acquisition Announcements?

An increasing fraction of M&A deals are announced on the same day in which the bidder reports its quarterly earnings, a phenomenon we call ‘bundled’ announcements. Compared to other bids, bundled bids are associated with strongly lower bidder announcement returns. We investigate possible reasons for this practice. Our findings indicate that bundling is a tool of strategic disclosure. Reported earnings of bundling acquirers are lower than those of other bidders. Bidders engage in bundling in moments of high investor attention, good earnings reports in the target industry, and when analysts’ views about the firm are divided.
Effects of zinc and influence of Acremonium lolii on growth parameters, chlorophyll a fluorescence and antioxidant enzyme activities of ryegrass (Lolium perenne L. cv Apollo).

The effects of zinc on growth, mineral content, chlorophyll a fluorescence, and detoxifying enzyme activity (ascorbate peroxidase (APX), EC 1.11.1.11; superoxide dismutase (SOD), EC 1.15. 1.1) of ryegrass infected or not by Acremonium lolii, and treated with nutrient solution containing 0-50 mM ZnSO(4) were studied. The introduction of zinc induces stress with a decrease in growth at 1, 5 and 10 mM ZnSO(4) and a cessation of growth at 50 mM ZnSO(4), in ryegrass plants infected by A. lolii or not. This decrease in growth may be due to an accumulation of zinc in leaves. Nevertheless, symbiotic plants showed higher values in tiller number, an advantage conferred by the fungus. After 24 d of Zn exposure, leaf fresh weights and leaf water content were lower in plants growing with Zn in the culture medium and no advantage was conferred by the fungus to its host. An increase in Zn supply resulted in a decrease of the Ca, K, Mg, and Cu content of the leaves, a reduction in the quantum yield of electron flow throughout photosystem II (DeltaF/F(1)(m))and a lowering of the efficiency of photosynthetic energy conversion (F(v)/F(m)), compared to control plants. To counter this zinc stress, detoxifying enzymes APX and SOD increased (100%) when Zn reached the value of 50 mM in the nutrient solution. At 10 mM ZnSO(4), the presence of the fungus in the plant led to an increase in the threshold toxicity of plants to zinc by a diminution of APX activity.