Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuroprotective effects of paeoniflorin: an emerging concept in neurology.

Communicating author: Shailendra Kapoor, Private practice, Chicago, IL, USA, e-mail: shailendrakapoor@yahoo.com Sun et al. have provided interesting data in their recent article in your esteemed journal [5]. Paeoniflorin exerts a number of neuroprotective effects in a wide range of neurological disorders. Paeoniflorin attenuates neuronal ischemia – reperfusion injury. Neurological deficit scores as well as cerebral infarction size are markedly attenuated [6]. It also reduces inflammation in the infarcted area as is evident by its attenuating effect on ICAM-1 and TNF-alpha. It also prevents chronic cognitive changes by downregulating the expression of NF-kappa B in the hippocampal astrocytes [3]. Similar protective effects are seen in steroid induced injured neurons. It up-regulates Bcl-2 expression while down-regulating Bax expression within the neuronal cells [4]. It also increases neurotrophic factor levels. Paeoniflorin also decreases the effects and extent of febrile seizures. It mediates this effect by decreasing the elevation of intracellular ionized calcium secondary to glutamate induced changes. It also mitigates intraneuronal mGluR5 induced elevation of ionized calcium [2]. Paeoniflorin is also of clinical benefit in mitigating the effects of Parkinson’s disease. It mediates this effect by altering neuronal autophagy. It reduces the influx of ionized calcium within the neuronal cells. Besides this, it increases the expression of LC3II and down-regulates LAMP2a expression in cerebral tissue [1]. The above examples clearly illustrate the neuroprotective effects of paeoniflorin.
Gaussian Beam Mode Analysis of Imaging Arrays

In this paper we consider the Gaussian beam mode analysis of imaging arrays on submillimetre-wave radio telescopes. We show how it is possible to describe any of the off-axis beams generated by the array in terms of the same on-axis beam mode set. The mapping process can be easily analysed using a modal approach.
The Air Spacer Technology for Improving the Cell Distribution in 1 Giga Bit NAND Flash Memory

Recently the cell integration density of NAND flash memory increases rapidly due to its simple structure suitable for high resolution lithography. However as the cell integration density increases, NAND flash memory cell shows the problem of increased parasitic capacitance between the cells. The problems are generated by the floating-gate interference during cell operation. In order to reduce the floating gate interference, it is necessary to adopt low-k dielectric material. In this work, we would like to propose the air spacer which has the lowest dielectric constant. We applied the air spacer technology on poly-Si/W six stack gate of 90 nm design-rule NAND flash device for the first time, which improved the cell operation characteristics
Sistem Informasi Penggajian dan Perhitungan PPh 21 pada PT. Lotron Indonesia Bekasi

The era of globalization, information technology moving rapidly. The computer is theequipment created to facilitate human work, to achieve good progress in hardware andsoftware.PT. Lotron Indonesia need an information system that support and facilitate the workprocess. To the writer tries to make research on the system of payroll and income tax reporting21 PT. Lotron Indonesia which is still not computerized. PT. Lotron Indonesia is a companyengaged in the textile field. Existing payroll system at PT. Lotron Indonesia is still done manually,from inputting attendance, payroll calculation, payroll and taxes, preparing reports salaries andtaxes up to data storage - other data related to payroll processing up to journal entries, so asenable during the process occurs recording errors, lack of accurate statements are made and thedelay in the search for the required data. Computerized system is the best solution to solveproblems - problems that exist in this company, as well as the computerized system can achievean activity which is effective and efficient in supporting the activities of this company. Keywords: Computerized system, Existing payroll system, Tax reporting 21
Characterisation of multiresistant Brachyspira hyodysenteriae isolates from Czech pig farms

The aim of the present study was to evaluate the importance of clonal spread of Brachyspira hyodysenteriae resistant to pleuromutilins (tiamulin, valnemulin) on farms in the Czech Republic. Agar dilution method and macrorestriction fragment profile analysis by pulsed field gel electrophoresis were used to characterise 35 B hyodysenteriae isolates that were obtained from clinical cases of swine dysentery on 32 farms between 2000 and 2005. Most isolates showed multiple resistances to tiamulin, valnemulin, tylosin and lincomycin. A total of six pulsotypes were detected in these multiresistant isolates. An analysis of epidemiological data showed that multiresistant B hyodysenteriae isolates were more often detected on fattening farms (59 per cent), compared with farms with other types of production. Furthermore, it was found that multiresistant B hyodysenteriae clones were most frequently selected on farms with endemic incidence of swine dysentery. This finding was confirmed by the characterisation of 21 B hyodysenteriae isolates obtained from three large-scale operations in seven consecutive years.
Should night eating syndrome be included in the DSM?

OBJECTIVE This article examines the status of the literature on night-eating syndrome (NES) according to five criteria that have been proposed by Blashfield, Sprock, and Fuller(1) (Compr Psychiatry 1990; 31:15-19) to determine whether NES warrants inclusion in the psychiatric nosology as a distinct eating disorder. METHOD Relevant research papers were identified in Medline and PsychInfo using the search term "night-eating syndrome. " RESULTS None of the five criteria was met. Specifically, at the time of review, there were not yet 25 empirical papers on NES; no commonly accepted definition of or assessment approach to NES has been adopted; the utility and validity of NES need to be established, and NES needs to be differentiated more clearly from other eating disorder syndromes. CONCLUSION This review suggests that the most pressing step toward clarifying the status of NES is to develop a uniform definition of NES. Once accomplished, research can progress to accumulating the necessary evidence to determine whether NES should be included in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders.
The Freud‐1/CC2D1A family: Transcriptional regulators implicated in mental retardation

The CC2D1A gene family consists of two homologous genes, Freud‐1/CC2D1A and Freud‐2/CC2D1B, that share conserved domains, including several DM14 domains that are specific to this protein family, a C‐terminal helix‐loop‐helix domain, and a C2 calcium‐dependent phospholipid binding domain. Although the function of Freud‐2 is unknown, Freud‐1 has been shown to function as a transcriptional repressor of the serotonin‐1A receptor gene that binds to a novel DNA element (FRE, 5′‐repressor element). The DNA binding and repressor activities of Freud‐1 are inhibited by calcium‐calmodulin‐dependent protein kinase. Recently, a deletion in the CC2D1A gene has been linked to nonsyndromic mental retardation. This deletion results in the truncation of the helix‐loop‐helix DNA binding and the C2 domains, crucial for Freud‐1 repressor activity, and hence is predicted to generate an inactive or weakly dominant negative protein. The possible mechanisms by which inactivation of Freud‐1 could lead to abnormal cortical development and cognitive impairment and the potential roles of Freud‐1 gene targets are discussed. © 2007 Wiley‐Liss, Inc.
Plasma Citrulline: A New Marker of Gut Epithelium Alteration in Obese Patients?

Objectives: In the last decade gut microbial diversity was associated with the pathogenesis of obesity in humans. Plasma citrulline was a simple and accurate biomarker for the severity of intestinal failure and was associated with short bowel syndrome and alteration of gut permeability, being developed as an alternative to D-xylose tolerance test for the diagnosis of an abnormal small intestinal absorption of nutrients. This study was performed to ascertain whether obesity might be associated with dysregulation of epithelial gut function. Methods: Fifteen obese individuals (5 M/10 F; BMI 37.4 ± 6.1 Kg/m2; 42 ± 6 yrs) and 15 healthy gender- and age-matched controls (6 M/9 F BMI: 22.7 ± 2.1 Kg/m2; 39 ± 7 yrs) underwent D-xylose load (25 g) and plasma citrulline, plasma insulin, glucose and lipid profile testing. Results: Plasma citrulline was significantly lower in the obese group (p = 0.045) with respect to controls, whilst total cholesterol, LDL and trygliceri- des concentration, insulin level and HOMA-IR were significantly higher in obese patients. In contrast, after D-xylose load no difference in serum xylose was found between the two groups (p = ns). Conclusions: Obese patients show a decreased citrulline concentration with respect to lean subjects. Since citrulline is a known marker of intestinal health, alterations in the gut epithelium are likely to be associated with the obesity syndrome. We propose to measure citrulline level in obese patients on a routine basis.
High-Resolution Confocal Microscopy with Simultaneous Electron and Laser Beam Irradiation

Abstract We have developed a fiber-based confocal optical microscope that operates inside of a commercial scanning electron microscope (SEM) instrument (JEOL 6400; JEOL Ltd., Tokyo, Japan) enabling the excitation of a sample either by a laser or by electron beam, and hence combining the complimentary techniques of photoluminescence and cathodoluminescence. The instrument uses single-mode fibers that enter the SEM by vacuum feedthroughs. The illumination and collection fibers operate as effective pinholes providing, in combination with a microscope objective (NA = 0.3), high spatial resolution (~2 μm) and excellent collection efficiency. The high spatial resolution ensures that the light collected from the sample is in a region of optimal laser beam and electron beam overlap. The capabilities of this instrument are tested by experiments involving the excitation of europium ions in situ doped in GaN thin films.
A power-on reset with accurate hysteresis

As the complexity of the digital circuit blocks continues to increase, a power-on reset, POR, circuit is needed to initialize the digital logic to the known state at the start-up. This paper represents a POR with thresholds that are insensitive to the rise time of the supply voltage. This is achieved by generating the POR pulse with a constant current reference circuit. Moreover, current mirroring is used to improve hysteresis. The designed POR has a quiescent current of 3.1 µA (VDD=3.6 V) and operates with supplies ranging from 3 V to 3.6 V. The area of the circuit is 109.9 µm × 106.65 µm and the chip was implemented with triple-well 0.35 µm HVCMOS process.
Teaching lab on the DSP implementation of the speed control of a DC machine

The present paper addresses the speed control of a DC machine in the context of an advanced teaching lab consisting in setting up an islanded production unit. The different steps followed by the student to design and implement the speed control of the DC machine used in this islanded production unit are explained. A hardware specifically designed for this teaching and consisting of a DSP and an Analog to Digital (A/D) converter is presented. The major steps for the design of the PI (Proportional-Integral) regulator are recalled, whereas different improvement techniques such as the Anti-Reset Windup (ARW) or the set value corrector are presented in details. The corresponding code implemented in a DSP is given and detailed. Different tests performed on the test bench are then discussed mainly in terms of response time and overshoot.
Some demographic characteristics of the domestic cat population in Great Britain with particular reference to feeding habits and the incidence of the feline urological syndrome.

The results are presented of a survey of 5, 669 domestic cats in Great Britain and the data used to define some of the normal demographic characteristics of the cat population with particular reference to feeding habits. An analysis of cats visiting a veterinary surgeon is given, and an incidence of between 0-34 and 0-55 % for the Feline Urological Syndrome in the total population at risk is suggested. The total cat population in Great Britain is calculated as 3-3 million.
Tackling childcare : the business case for employer-supported childcare

Almost one in 10 of the world’s population, 679 million, are children younger than five years old. To thrive and develop, these children and their older siblings need care. For the International Finance Corporation (IFC), a member of the World Bank Group and the largest global development institution focused exclusively on the private sector in developing countries, improving access to childcare goes hand in hand with fostering workplace gender diversity, and helping parents enter and advance in the workforce while enabling companies to strengthen their bottom line. IFC’s focus on removing barriers, such as lack of childcare, to women’s (and men’s) access to more and better jobs is embedded in the World Bank Group’s gender strategy and IFC’s vision focused on creating markets, particularly in fragile, conflict-affected, and low-income countries. In countries where employer-supported childcare is mandatory, IFC is working with its clients to substantiate the business case and to help them go beyond compliance and implement childcare strategies best suited to their business needs, thus resulting in better business results.
Shedding Light on the DNA Damage Checkpoint

DNA damage checkpoint genes are required to restrain cell cycle progression during DNA repair and to maintain chromosome stability. Checkpoint mutants are highly sensitive to killing by UV light, so the responses mediated by these genes are likely to be essential for survival during exposure to solar radiation. Yet it is still unclear exactly how checkpoint responses coordinate the cell cycle with DNA repair in the presence of UV lesions. At high doses, the UV response shares features with the ionizing radiation response, such as G1/S and G2/M checkpoints. At lower doses, only a postreplication checkpoint is evident. In this perspective we attempt to reconcile these observations and address their physiological meaning, with an emphasis on insights gained from direct cell-cycle measurements and recent studies in yeast.
Application of the Subtractive Genomics and Molecular Docking Analysis for the Identification of Novel Putative Drug Targets against Salmonella enterica subsp. enterica serovar Poona

The emergence of novel pathogenic strains with increased antibacterial resistance patterns poses a significant threat to the management of infectious diseases. In this study, we aimed at utilizing the subtractive genomic approach to identify novel drug targets against Salmonella enterica subsp. enterica serovar Poona strain ATCC BAA-1673. We employed in silico bioinformatics tools to subtract the strain-specific paralogous and host-specific homologous sequences from the bacterial proteome. The sorted proteome was further refined to identify the essential genes in the pathogenic bacterium using the database of essential genes (DEG). We carried out metabolic pathway and subcellular location analysis of the essential proteins of the pathogen to elucidate the involvement of these proteins in important cellular processes. We found 52 unique essential proteins in the target proteome that could be utilized as novel targets to design newer drugs. Further, we investigated these proteins in the DrugBank databases and 11 of the unique essential proteins showed druggability according to the FDA approved drug bank databases with diverse broad-spectrum property. Molecular docking analyses of the novel druggable targets with the drugs were carried out by AutoDock Vina option based on scoring functions. The results showed promising candidates for novel drugs against Salmonella infections.
Load identification in dynamic wireless power transfer system utilizing current injection in the transmitting coil

In this paper, a load identification approach for dynamic wireless power transfer for electric vehicles is introduced. In the proposed method, determination of the load parameters and position are achieved without requiring any communication link between the transmitter and receiver or using any extra coil. The load detection procedure is achievable using two modes: the energy injection mode and the free resonant mode. The operating principles and theoretical analysis of this method are presented in this paper, together with experimental results.
IAEA-TECDOC-533 THE RECOVERY OF URANIUM FROM PHOSPHORIC ACID

Commercialization of three processes (OPPA, DBPA-TOPO and OPAP) has shown that the DEPA-TOPO process offers the best technology available today for the recovery of uranium from wet-process phosphoric acid. Uranium recovery plants using this process have been successfully operated in the United States, Belgium, Canada and Taiwan. Operating experience from these plants has led to a significant reduction in both capital and operating costs making the DEPA-TOPO process more attractive in today's depressed uranium market. The main process improvements developed at the Oak Ridge National Laboratories are summarized and current process economics are reviewed. New processes now being studied are discussed, including processes using new extractants, ion-exchange resins and liquid membranes and processes for the recovery of uranium from the hemi-hydrate phosphoric acid process.
A model of Credit Bureau in Serbia -instruments for preserving stability of the banking sector in conditions of global economic crisis

This paper presents the characteristics of the banking system in serbia before and during the global financial crisis. The model of the credit bureau in serbia which, according to its technical characteristics and the level of business performance, represents the original solution is analyzed. Its implementation, in conjunction with other control mechanisms, has provided the stability of the banking sector in terms of crisis. Consequently, the control of liquidity in the banking sector is achieved as well as the control of the expansion of credit activities, with the maintenance of population and economy indebtedness at optimal level, which is of great importance in terms of global crisis when economic policy makers in serbia, faced with a pronounced deficit in balance of payments of the country, as one of economic policy measures aimed at improving the balance of payment position, implement the measure of controlled reduction of private demand.
Ultrasound guided supraclavicular subclavian cannulation: A novel technique using “hockey stick” probe

Dear Editor, Cannulation of subclavian vein (SV) is preferred due to reduced infection rates, reduced mechanical problems, reduced risk of thrombosis, and patient comfort. Its large diameter, absence of valves, and ability to remain patent in hypovolemic patients is an added advantage.We describe the use of a L-shaped “hockey stick” probe (HSP) for real time ultrasound (US) guided supraclavicular (SUC) subclavian central line placement.
Optimal Interval between Middle Cerebral Artery Velocity Measurements when Monitoring Pregnancies Complicated by Red Cell Alloimmunization

Objective: To evaluate the optimal interval between middle cerebral artery (MCA) Doppler measurements when monitoring pregnancies complicated by red cell alloimmunization. Methods: Thirty-nine fetal blood samplings (FBS) performed on 24 pregnant women with red blood cell alloimmunization followed up using both MCA peak systolic velocity and time-averaged mean velocity measurements on weekly basis. Results: In total, 65.5 and 37.5% of women with moderate or severe fetal anemia had abnormal MCA Doppler values 1 and 2 weeks, respectively, before FBS was performed. Conclusions: A weekly assessment of women at risk for fetal anemia is optimal in most of the cases even though 35.5% of cases of moderate or severe fetal anemia are expected to have normal Doppler measurements the week before the decision of doing an FBS is made.
Frequency Ranges of Heart Rate Variability Related to Autonomic Nerve Activity in the Mouse

Mice have gained more and more attention in recent years and been widely used in transgenic experiments. Although the number of researches on the heart rate variability (HRV) of mice has been gradually increasing, a consensus on the frequency ranges of autonomic modulation has not been established. Therefore, the main purpose of this study was to find a HRV “prototype” for conscious mice in the state of being motionless and breathing regularly (called “genuinely resting”), and to determine the frequency ranges corresponding to the autonomic modulation. Further, whether these frequencies will change when the mice move freely was studied to evaluate the feasibility of the HRV spectrum as an index of the autonomic modulation of mice. The recording sites were specially arranged to simultaneously obtain the electrocardiography and electromyography data to be provided for the use of HRV analysis and motion monitoring, respectively. The states of being motionless and breathing regularly as judged from the electromyography results were selected as a genuine resting state of a conscious mouse. The frequencies related to autonomic modulation of HRV were determined by comparing the spectrum changes before and after blockades of the autonomic tone by different pharmaceutical agents in both the genuine resting state and freely moving states. Our results showed that the HRV of mice is not suitable for indexing sympathetic modulation; however, it is possible to use the spectral power in the frequency range between 0.1 and 1 Hz as an index of parasympathetic modulation.
Attenuation of Staurosporine-Induced Apoptosis, Oxidative Stress, and Mitochondrial Dysfunction by Synthetic Superoxide Dismutase and Catalase Mimetics, in Cultured Cortical Neurons

Neuronal apoptosis induced by staurosporine (STS) involves multiple cellular and molecular events, such as the production of reactive oxygen species (ROS). In this study, we tested the efficacy of two synthetic superoxide dismutase/catalase mimetics (EUK-134 and EUK-189) on neuronal apoptosis, oxidative stress, and mitochondrial dysfunction produced by STS in primary cortical neuronal cultures. Exposure of cultures to STS for 24 h increased lactate dehydrogenase (LDH) release, the number of apoptotic cells, and decreased trypan blue exclusion. Pretreatment with 20 microM EUK-134 or 0.5 microM EUK-189 significantly attenuated STS-induced neurotoxicity, as did pretreatment with the caspase-1 inhibitor, Ac-YVAD-CHO, but not the caspase-3 inhibitor, Ac-DEVD-CHO. Posttreatment (1-3 h following STS exposure) with 20 microM EUK-134 or 0.5 microM EUK-189 significantly reduced STS-induced LDH release, in a time-dependent manner. Exposure of cultures to STS for 1 h produced an elevation of ROS, as determined by increased levels of 2,7-dichlorofluorescein (DCF). This rapid elevation of ROS was followed by an increase in lipid peroxidation, and both the increase in DCF fluorescence and in lipid peroxidation were significantly blocked by pretreatment with EUK-134. STS treatment for 3-6 h increased cytochrome c release from mitochondria into the cytosol, an effect also blocked by pretreatment with EUK-134. These results indicate that intracellular oxidative stress and mitochondrial dysfunction are critically involved in STS-induced neurotoxicity. However, there are additional cellular responses to STS, which are insensitive to treatment with radical scavengers that also contribute to its neurotoxicity.