Miracle-dz/UniFAR-FTUs huggingface dataset:
Climate Change Vulnerability of American Lobster Fishing Communities in Atlantic Canada

Climate change impacts on fisheries will undoubtedly have socio-economic impacts on coastal communities and the seafood market. However, it is a challenge to integrate climate change information in a form that can be used efficiently by adaptation planners, policy makers and fishery managers. In this study, we frame a climate change impact assessment using a geographical perspective based on the management units of the dominant fishery, in this case, American lobster in Nova Scotia, Canada. The information considered here includes economic dependence on the fishery, population size, diversity of the fishery revenue, status of harbour infrastructure, total replacement cost of each harbour, increased relative sea level and flooding, and the vulnerability of offshore lobster to ocean warming and changes in zooplankton composition and anticipatory changes in fishery productivity across management borders. Using two ocean models to provide multi-decadal scale projections of bottom temperature, changes in offshore lobster distribution are projected to have a neutral, or positive impact on the region as a whole. However, when lobster vulnerability is combined with climate change related vulnerabilities of coastal fishing communities, it is evident that adaptation planning is needed for long-term sustainability. This impact assessment provides both a framework and information for further in-depth analyses by climate change adaptation planners and fishery managers.
Prognostic Values of Platelet-Associated Indicators in Resectable Cervical Cancer

Background: Cervical cancer is one of the leading causes of cancer mortality in women, which seriously threatens the health of women worldwide. Platelet (PLT)-related parameters, including PLT count, mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW), are correlated with tumor prognosis. Methods: In total, 110 patients with cervical carcinoma were recruited in this study. The patients were divided into 2 groups according to the receiver operating characteristic analysis cutoff values of PLT, MPV, PCT, or PDW. The post-/preradiotherapy ratios were defined as the rate of preradiotherapy PLT-related parameters counts and the corresponding ones obtained after radiotherapy. Results: Higher pretreatment PLT level was correlated with Higher Federation of Gynecology and Obstetrics (FIGO) stage (II). Higher pretreatment PLT level was correlated with worse progression-free survival (PFS) and overall survival (OS). Increased post-/preradiotherapy ratio of PLT was correlated with worse PFS and OS. Changes in PCT, MPV, or PDW levels had no effects on PFS or OS. Cox regression analysis model indicated that larger tumor size, higher pretreatment PLT level, and increased post-/preradiotherapy PLT ratio were independently associated with worse PFS; higher FIGO stage (II) and increased post-/preradiotherapy PLT ratio were independently associated with worse OS. Conclusion: Pretreatment PLT level and increased post-/preradiotherapy PLT ratio are correlated with outcomes of cervical cancer.
Sex- and fiber-type-related contractile properties in human single muscle fiber

This study aimed to examine the distribution and contractile properties of single muscle fiber sex/myosin heavy chain (MHC) type-related differences and to evaluate the correlation of cross-sectional area (CSA) and specific force (SF) in a single muscle fiber. Six young men and six young women were participated in this study. Muscle sample was obtained from vastus lateralis muscle. To examine potential gender differences within each fiber contractile properties (CSA, maximal isometric force, SF, maximal shortening velocity) and relationship between CSA and SF of single fiber using Pearson correlation. After mechanical measurements, single muscle fiber determined MHC isoforms using silver stain. MHC isoform composition did not differ by sex (chi-square=6.978, P=0.073). There were sex-related differences in CSA and maximal isometric force (P<0.05), but no fiber type-related differences (P>0.05). Related to SF and maximal shortening velocity, there were no sex-related differences only fiber type-related differences (P<0.05). However, there were differences in SF between single fiber types in men but not in women. A negative correlation was found between CSA and SF in both men and women (P<0.05). It is suggested that there might be different mechanical properties of cross-bridges according to sex.
Identifying Disparities in the Management of Hip Fractures Within Europe: A Comparison of 3 Health-Care Systems

Introduction: This study investigates the management of hip fractures in a German maximum care hospital and compares these data to evidence-based standard and practice in 180 hospitals participating in the UK National Hip Fracture Database (NHFD) and 16 hospitals participating in the Irish Hip Fracture Database (IHFD). This is the first study directly comparing the management of hip fractures between 3 separate health-care systems within Europe. Methods: Electronic medical data were collected retrospectively describing the care pathway of elderly patients with a hip fracture admitted to a large trauma unit in the south of Germany “University Hospital Freiburg” (UHF). The audit evaluated demographics, postoperative outcome, and the adherence to the 6 “Blue Book” standards of care. These data were directly compared with the data from the UK NHFD and the IHFD acquired from 180 and 16 hospitals, respectively. Results: At 36 hours, 95.8% of patients had received surgery in UHF, compared to 71.5% in the NHFD and 58% of patients in the IHFD. The rate of in-hospital mortality was 4.7% compared to 7.1% in the NHFD and 5% in the IHFD. The mean average acute length of stay was 13.4 days compared to 16.4 days in the NHFD and 20 days in the IHFD. Reoperation rates are 3.3% compared to 1% in the NHFD and 1.1% in the IHFD; 50.5% of patients were discharged on bone protection medication, compared to 47% in the IHFD and 79.3% in the UK NHFD. Discussion: Despite uniformly acknowledged evidence-based treatment guidelines, the management of hip fractures remains heterogeneous within Europe. Conclusion: These data show that different areas of the hip fracture care pathway in Germany, England, and Ireland, respectively, show room for improvement in light of the growing socioeconomic burden these countries are expected to face.
Effects of kinesiotape on pain, range of motion, and functional status in patients with osteoarthritis: a randomized controlled trial

This study aimed to determine the effects of kinesiotape (KT) on pain, range of motion, and functional status in patients with osteoarthritis of the knee. In this randomized controlled trial, patients with knee osteoarthritis, based on American College of Rheumatology criteria, and Kellgren-Lawrence grade 2 or 3 criteria were selected. Visual analogue scale and active range of motion were the primary outcome measures. Timed Up and Go test and 6-min walk test, were the secondary outcome measures. Evaluation was performed at baseline (T0), after 1 hr (T1), and after 72 hr (T2). We recruited 27 patients with osteoarthritis (age, 57.33±8.72 years; 63% female; body mass index, 29.7±4.3 kg/m2) who were randomly assigned into KT or sham-KT groups. There was a significant group by time interaction for the visual analogue scale (P< 0.001, η2=0.593), active range of motion (flexion) (P<0.001, η2=0.492), active range of motion (extension) (P<0.001, η2=0.351), 6-min walk test (P<0.001, η2=0.568), and Timed Up and Go test (P=0.026, η2=0.136). Between-group comparisons revealed significant differences between KT and sham-KT in visual analogue scale and Timed Up and Go test in T1 and T2 assessments, with changes in knee flexion (P<0.002) and extension active range of motion (P<0.010) and 6-min walk test (P<0.044) at 72-hr posttreatment. This study showed that, 1 hr of KT is an effective treatment for decreasing pain and improving active range of motion and physical function at a 72-hr follow-up in patients with osteoarthritis.
The immediate influence of various whole-body vibration frequency on balance and walking ability in children with cerebral palsy: a pilot study

The purpose of this pilot study is to examine the immediate effect of interventions based on the frequency of whole-body vibration on children with cerebral palsy’s balance and walking abilities. A total of 12 were selected as subjects. All subjects measured 10-m walking test (10MWT), Timed Up and Go (TUG) test and measured sway length (SL) and limit of stability (LOS) by bio-rescue. And those were performed again after the frequencies of the 12, 18, and 26 Hz were applied respectively. To check the immediate effect, all subjects performed only one frequency of interventions per day and no other treatment was performed in parallel to control the foreign variables. After intervention, 10MWT were significantly increased in the 12 and 18 Hz groups (P<0.05). TUG test and LOS were significantly increased in the 18 Hz group (P<0.05). There were no significant differences on TUG, SL, and LOS in the 12 Hz group. There were no significant differences on 10MWT, TUG, SL, and LOS in the 26 Hz group. Looking at the results of this study, the immediate effect of whole-body vibration shows that the frequency of the 18 Hz group is the most effective interventions in promoting walking and balancing abilities in children with cerebral palsy than frequencies of the 12 and 26 Hz groups.
A measurement of the Hubble constant from angular diameter distances to two gravitational lenses

Lensing approach to the Hubble constant The current expansion rate of the Universe is parametrized by the Hubble constant, H0. Different methods of measuring H0 produce results that disagree with each other, which could be a sign of new physics or of systematic errors in the methods. Jee et al. have analyzed two gravitational lensing systems to determine their distances (see the Perspective by Davis). They use these as benchmarks for a measurement of H0. The precision is not sufficient to resolve the debate but does bypass some of the systematic uncertainties. Observations of more lensing systems will be required to narrow down the value of H0. Science, this issue p. 1134; see also p. 1076 The rate of expansion of the Universe is determined from observations of gravitational lensing systems. The local expansion rate of the Universe is parametrized by the Hubble constant, H0, the ratio between recession velocity and distance. Different techniques lead to inconsistent estimates of H0. Observations of Type Ia supernovae (SNe) can be used to measure H0, but this requires an external calibrator to convert relative distances to absolute ones. We use the angular diameter distance to strong gravitational lenses as a suitable calibrator, which is only weakly sensitive to cosmological assumptions. We determine the angular diameter distances to two gravitational lenses, 810−130+160 and 1230−150+180 megaparsec, at redshifts z=0.295 and 0.6304. Using these absolute distances to calibrate 740 previously measured relative distances to SNe, we measure the Hubble constant to be H0=82.4−8.3+8.4 kilometers per second per megaparsec.
Humboldt’s enigma: What causes global patterns of mountain biodiversity?

Mountains contribute disproportionately to the terrestrial biodiversity of Earth, especially in the tropics, where they host hotspots of extraordinary and puzzling richness. With about 25% of all land area, mountain regions are home to more than 85% of the world’s species of amphibians, birds, and mammals, many entirely restricted to mountains. Biodiversity varies markedly among these regions. Together with the extreme species richness of some tropical mountains, this variation has proven challenging to explain under traditional climatic hypotheses. However, the complex climatic characteristics of rugged mountain regions differ fundamentally from those of lowland regions, likely playing a key role in generating and maintaining diversity. With ongoing global changes in climate and land use, the role of mountains as refugia for biodiversity may well come under threat.
Variability in the Duration and Thoroughness of Hand Hygiene

Abstract We observed 354 hand hygiene instances across 41 healthcare workers doffing personal protective equipment at 4 hospital-based biocontainment units. We measured the duration and thoroughness of each hand hygiene instance. Both parameters varied substantially, with systematic differences between hospitals and differences between healthcare workers accounting for much of the variance.
Leukocyte Adhesion Defect Type 1. Reporting Patient Series and their Survival Without Bone Marrow Transplantation

The survival of patients suffering from severe LADI is discussed in this paper. The approach is to do bone marrow transplantation as soon as possible, however, we report 4 patients suffering from severe LADI, who did not have bone marrow transplantation. We report the favorable outcome with conservative treatment (prophylactic antibiotics) إن المرضى الذين يعانون من نقص شديد في جزيئات الالتصاق على خلايا البيضاء عادة ما يحتاجون إلى زراعة نقي النخاع العظمى للعلاج. نحن نقدم أربع حالات تم تشخيصها في مدينة نابلس، ولم تتم عملية زرع نقي النخاع لهم. وقد كانت النتيجة مرضية باستعمال العلاجات الوقائية فقط (مضادات حيوية وقائية)
Ongoing and Focused Provider Performance Evaluations in Emergency Medicine: Current Practices and Modified Delphi to Guide Future Practice

The Joint Commission requires ongoing and focused provider performance evaluations (OPPEs/FPPEs). The authors aim to describe current approaches in emergency medicine (EM) and identify consensus-based best practice recommendations. An online survey was distributed to leaders in EM to gain insight into current practices. A modified Delphi approach was then used to develop consensus to recommend best practice. A variety of strategies are currently in use for OPPE/FPPE. “Peer reviewed cases with opportunity for improvement” was identified as a preferred metric for OPPE. Although the preference was for use of peer review in OPPE, a consistent and standard adoption of robust internal care review processes is needed to establish expected norms. National benchmarking is not available currently. This was a limited survey of self-identified leaders, and there is an opportunity for additional engagement of leaders in EM to identify a unified approach that appropriately relates to patient outcomes.
Contribution of Resident Memory CD8+ T Cells to Protective Immunity against Respiratory Syncytial Virus and Their Impact on Vaccine Design

Worldwide, human respiratory syncytial virus (RSV) is the most common etiological agent for acute lower respiratory tract infections (ALRI). RSV-ALRI is the major cause of hospital admissions in young children, and it can cause in-hospital deaths in children younger than six months old. Therefore, RSV remains one of the pathogens deemed most important for the generation of a vaccine. On the other hand, the effectiveness of a vaccine depends on the development of immunological memory against the pathogenic agent of interest. This memory is achieved by long-lived memory T cells, based on the establishment of an effective immune response to viral infections when subsequent exposures to the pathogen take place. Memory T cells can be classified into three subsets according to their expression of lymphoid homing receptors: central memory cells (TCM), effector memory cells (TEM) and resident memory T cells (TRM). The latter subset consists of cells that are permanently found in non-lymphoid tissues and are capable of recognizing antigens and mounting an effective immune response at those sites. TRM cells activate both innate and adaptive immune responses, thus establishing a robust and rapid response characterized by the production of large amounts of effector molecules. TRM cells can also recognize antigenically unrelated pathogens and trigger an innate-like alarm with the recruitment of other immune cells. It is noteworthy that this rapid and effective immune response induced by TRM cells make these cells an interesting aim in the design of vaccination strategies in order to establish TRM cell populations to prevent respiratory infectious diseases. Here, we discuss the biogenesis of TRM cells, their contribution to the resolution of respiratory viral infections and the induction of TRM cells, which should be considered for the rational design of new vaccines against RSV.
Association Between High‐Sensitivity Cardiac Troponin T and Echocardiographic Parameters in Chronic Kidney Disease: Results From the KNOW‐CKD Cohort Study

Background It is unclear whether high‐sensitivity troponin T (hs‐TnT) is associated with subclinical cardiac changes in chronic kidney disease (CKD). We evaluated the relationship between hs‐TnT and left ventricular structure and function in a CKD population, according to estimated glomerular filtration rate. Methods and Results We analyzed 2017 patients with CKD stages 1 to 5 (predialysis) in the KNOW‐CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) cohort. The predictor was hs‐TnT level measured at baseline, and the outcomes were left ventricular hypertrophy (LVH) and systolic and diastolic dysfunction shown by echocardiography at baseline and after 4 years. Participants were categorized into quartiles according to hs‐TnT levels. The associations between quartiles of hs‐TnT and outcomes were assessed using multivariable logistic regression analysis with confounders including demographics, medical history, and laboratory findings. A receiver operating characteristic curve was used to assess the diagnostic power of hs‐TnT for the outcomes as a continuous variable. For subgroup analysis, patients were stratified based on an estimated glomerular filtration rate of 60 mL/min per 1.73 m2. Elevated hs‐TnT was associated with LVH and diastolic dysfunction at baseline in an adjusted model but was not associated with systolic dysfunction. These associations remained significant for both estimated glomerular filtration rate subgroups. Receiver operating characteristic curve analysis showed that hs‐TnT as a continuous variable exhibited fair significance for detection of LVH (area under the curve: 0.689) and diastolic dysfunction (area under the curve: 0.744). Multivariable analysis showed that higher hs‐TnT levels at baseline were related to development of LVH but not diastolic dysfunction (n=864). Conclusions In CKD patients, hs‐TnT is strongly associated with alterations of left ventricular structure and diastolic dysfunction for both estimated glomerular filtration rate strata. Baseline hs‐TnT levels are predictive of new LVH on follow‐up.
Subwavelength polarization splitter-rotator with ultra-compact footprint.

An ultra-compact polarization splitter-rotator with a discretized subwavelength nanostructure is demonstrated on the silicon-on-insulator platform. The device has a length of only 7.92 μm. For TE0-TE0, a low insertion loss (<0.2 dB), low crosstalk (<-20 dB), and high extinction ratio (>40 dB) are achieved over a broad wavelength range from 1500 nm to 1600 nm. For TM0-TE0, the insertion loss is lower than 1 dB over 40 nm bandwidth (1530-1570 nm). The crosstalk is lower than -25 dB, and the extinction ratio is larger than 20 dB, from 1500 nm to 1600 nm.
Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action

The known mode of action of isoniazid (INH) is to inhibit bacterial cell wall synthesis following activation by the bacterial catalase–peroxidase enzyme KatG in Mycobacterium tuberculosis (Mtb). This simplistic model fails to explain (a) how isoniazid penetrates waxy granulomas with its very low lipophilicity, (b) how isoniazid kills latent Mtb lacking a typical cell wall, and (c) why isoniazid treatment time is remarkably long in contrast to most other antibiotics. To address these questions, a novel comprehensive mode of action of isoniazid has been proposed here. Briefly, isoniazid eradicates latent tuberculosis (TB) by prompting slow differentiation of pro‐inflammatory monocytes and providing protection against reactive species‐induced “self‐necrosis” of phagocytes. In the case of active TB, different immune cells form INH‐NAD+ adducts to inhibit Mtb's cell wall biosynthesis. This additionally suggests that the antibacterial properties of INH do not rely on KatG of Mtb. As such, isoniazid‐resistant TB needs to be re‐evaluated.
Preoperative anxiety can cause convulsion and severe hypotension immediately after spinal anaesthesia for caesarean delivery: a case report

Preoperative anxiety in patients under spinal anaesthesia may cause serious complications. We report a case of combined transient convulsion and severe hypotension immediately after spinal anaesthesia for caesarean delivery in a patient who presented with severe preoperative anxiety. Our patient’s consciousness and blood pressure recovered normally without any sequelae. However, preoperative anxiety can induce such complications, particularly in patients under regional anaesthesia. Therefore, early detection and deliberate management for preoperative anxiety are required for the patient’s safety and satisfaction.
Improving the production of podophyllotoxin in hairy roots of Hyptis suaveolens induced from regenerated plantlets

Ten Hyptis suaveolens hairy root lines were established by infecting nodal explants with K599+pGus-GFP+ and ATCC15834+pTDT strains from Agrobacterium rhizogenes. Genetic transformation was confirmed by epifluorescence and plagiotropic hairy root growth in absence of growth regulators. Cytotoxicity was determined using the sulforhodamine B method, and the production of podophyllotoxin (PTOX) was measured by high performance thin layer chromatography scanning. Through these methodologies, HsTD10 was identified as the hairy root line with the highest cytotoxicity and PTOX production, which was corroborated by liquid chromatography-mass spectrometry and micrOTOF-Q II. A suspension culture of HsTD10 was established in which PTOX and carbohydrate consumption during growth kinetics were quantified by high-performance liquid chromatography. Procedures to increase the production and retrieval of PTOX in the HsTD10 line included selection of culture medium, addition of thiamine, and modification of the PTOX extraction method. The best combination of these variables was MS medium at 75% of its components with the addition of 2 mg L-1 of thiamine, extraction with methanol-dichloromethane, and sonication at 40 ± 5°C. During kinetics, growth-associated PTOX accumulation was observed. The specific growth rate (μ) was 0.11 d-1. The highest concentration of PTOX obtained with HsTD10 (5.6 mg g-1 DW) was 100 times higher than that reported for roots of wild plants and 56 times higher than that for in vitro nontransformed roots of H. suaveolens.