Miracle-dz/UniFAR-FTUs huggingface dataset:
Throwing a Bomb on a Person Versus Throwing a Person on a Bomb

Most people consider it morally acceptable to redirect a trolley that is about to kill five people to a track where the trolley would kill only one person. In this situation, people seem to follow the guidelines of utilitarianism by preferring to minimize the number of victims. However, most people would not consider it moral to have a visitor in a hospital killed to save the lives of five patients who were otherwise going to die. We conducted two experiments in which we pinpointed a novel factor behind these conflicting intuitions. We show that moral intuitions are influenced by the locus of the intervention in the underlying causal model. In moral dilemmas, judgments conforming to the prescriptions of utilitarianism are more likely when the intervention influences the path of the agent of harm (e.g., the trolley) than when the intervention influences the path of the potential patient (i.e., victim).
Optic nerve head edema among patients presenting to the emergency department

Objective To determine the frequency of and predictive factors for optic nerve head edema (ONHE) among patients with headache, neurologic deficit, visual loss, or elevated blood pressure in the emergency department (ED). Methods Cross-sectional analysis was done of patients with ONHE in the prospective Fundus Photography vs Ophthalmoscopy Trial Outcomes in the Emergency Department (FOTO-ED) study. Demographics, neuroimaging results, management, and patient disposition were collected. Patients in the ONHE and non-ONHE groups were compared with bivariate and logistic regression analyses. Results Of 1,408 patients included, 37 (2.6%, 95% confidence interval 1.9–3.6) had ONHE (median age 31 [interquartile range 26–40] years, women 27 [73%], black 28 [76%]). ONHE was bilateral in 27 of 37 (73%). Presenting complaints were headache (18 of 37), visual loss (10 of 37), acute neurologic deficit (4 of 37), elevated blood pressure (2 of 37), and multiple (3 of 37). The most common final diagnoses were idiopathic intracranial hypertension (19 of 37), CSF shunt malfunction/infection (3 of 37), and optic neuritis (3 of 37). Multivariable logistic regression found that body mass index ≥35 kg/m2 (odds ratio [OR] 1.9, p = 0.0002), younger age (OR 0.5 per 10-year increase, p < 0.0001), and visual loss (OR 5, p = 0.0002) were associated with ONHE. Patients with ONHE were more likely to be admitted (62% vs 19%), to be referred to other specialists (100% vs 54%), and to receive neuroimaging (89% vs 63%) than patients without ONHE (p < 0.001). Fundus photographs in the ED allowed initial diagnosis of ONHE for 21 of 37 (57%) patients. Detection of ONHE on ED fundus photography changed the final diagnosis for 10 patients. Conclusions One in 38 patients (2.6%) presenting to the ED with a chief complaint of headache, neurologic deficit, visual loss, or elevated blood pressure had ONHE. Identification of ONHE altered patient disposition and contributed to the final diagnosis, confirming the importance of funduscopic examination in the ED.
Race, sex, drug use, and progression of human immunodeficiency virus disease.

BACKGROUND The rates of progression of human immunodeficiency virus (HIV) infection and survival have been reported to differ among sociodemographic groups. It is unclear whether these differences reflect biologic differences or differences in access to medical care. METHODS We measured disease progression and survival in a cohort of 1372 patients seropositive for HIV who were treated at a single urban center (median follow-up, 1.6 years). We calculated the rates of survival for the entire cohort and the rates of progression to the acquired immunodeficiency syndrome (AIDS) or death among the 740 patients who presented without AIDS. We used Cox proportional-hazards analysis to examine factors associated with progression to AIDS and death. RESULTS Progression to AIDS or death was associated with a CD4 cell count of 201 to 350 per cubic millimeter (relative risk, 2.0; P < 0.001), the presence of symptoms at base line (relative risk, 2.0; P < 0.001), prior antiretroviral therapy (relative risk, 1.7; P = 0.003), and older age (relative risk per year of age, 1.02; P = 0.03). However, there was no relation between disease progression and sex, race, injection-drug use, income, level of education, or insurance status. In the entire cohort, a lower CD4 cell count, a diagnosis of AIDS, older age, and the receipt of antiretroviral therapy before enrollment were associated with an increased risk of death, whereas the use of prophylaxis against pneumocystis pneumonia, zidovudine use after enrollment, and having a job at base line were associated with lower risks of death. There was no significant difference in survival between men and women, blacks and whites, injection-drug users and those who did not use drugs, or patients whose median annual incomes were $5,000 or less and those whose incomes were more than $5,000. CONCLUSIONS Among patients with HIV infection who received medical care from a single urban center, there were no differences in disease progression or survival associated with sex, race, injection-drug use, or socioeconomic status. Differences found in other studies may reflect differences in the use of medical care.
Susceptibility of naïve and differentiated PC12 cells to Japanese encephalitis virus infection

Japanese encephalitis is a mosquito‐borne disease caused by Japanese encephalitis virus (JEV) infection. Although JEV infects and replicates in cells with multiple tissue origins, neurons are the preferential cells for JEV infection. Currently, the identities of JEV cell tropism are largely unclear. To gain better insight into the underlying identities of JEV cell tropism, this study was designed to compare the JEV cell tropism with naïve or differentiated PC12 cells. Through nerve growth factor‐differentiated PC12 cells, we discovered that JEV efficiently replicated in differentiated PC12 cells rather than naïve cells. Mechanistic studies revealed that viral adsorption/attachment seemed not to be a crucial factor. Supporting data showed that antagonizing postreceptor intracellular signaling of interferons, along with the activation of suppressor of cytokine signaling‐3 (SOCS3) expression and protein tyrosine phosphatase activity, were apparent in differentiated PC12 cells after JEV infection. Independent of differentiating inducing agents, the upregulation of SOCS3 expression and protein tyrosine phosphatase activity, as well as preferential JEV tropism, were common in JEV‐infected differentiated PC12 cells. Using cultured primary neurons, JEV efficiently replicated in embryonic neurons rather than adult neurons, and the preference was accompanied by higher SOCS3 expression and protein tyrosine phosphatase activity. Given that both SOCS3 and protein tyrosine phosphatases have been implicated in the process of neuronal differentiation, JEV infection seems to not only create an antagonizing strategy to escape host's interferon antiviral response but also takes advantage of cellular machinery to favor its replication. Taken together, current findings imply that dynamic changes within cellular regulators of antiviral machinery could be accompanied by events of neuronal differentiation, thus concurrently playing roles in the control of JEV cell tropism and replication. © 2017 IUBMB Life, 69(2):79–87, 2017
Clinical impact of postprogression survival for overall survival in elderly patients (aged 75 years or older) with advanced nonsmall cell lung cancer.

INTRODUCTION The effects of first-line single-agent chemotherapy on overall survival (OS) might be confounded by subsequent treatments in elderly patients with nonsmall cell lung cancer (NSCLC). We, therefore, aimed to evaluate whether progression-free survival (PFS), postprogression survival (PPS), or tumor response might be a valid surrogate endpoint for OS in this patient population. PATIENTS AND METHODS We retrospectively reviewed the clinical data of 58 elderly patients with advanced NSCLC, who received first-line single-agent cytotoxic chemotherapy at our institution between October 2003 and November 2013. The relationships of PFS, PPS, and tumor response with OS were individually analyzed. RESULTS The study cohort included 46 men and 12 women with a median age of 79 years (range: 75-87 years). There were 30 adenocarcinomas, 22 squamous cell carcinomas, and 6 other histologic types with 1 stage IIIA, 9 IIIB, and 48 IV cases. The performance status (PS) scores were 0, 1, and 2 in 18, 35, and 5 patients, respectively. The median PFS and OS were 2.8 and 5.4 months, respectively. Our analyses revealed a strong correlation of PPS and PFS with OS, whereas that between tumor shrinkage and OS was weak. Tumor stage and PS after initial treatment were significantly associated with PPS. Individual analysis indicated that PPS might serve as a surrogate for OS in elderly patients with advanced NSCLC receiving first-line single-agent chemotherapy. CONCLUSION Our findings suggested that the disease course after progression following first-line single-agent chemotherapy might influence the OS of elderly patients with advanced NSCLC.
Effects of isovalerate on ruminal fermentation, urinary excretion of purine derivatives and digestibility in steers.

The objective of this study was to evaluate the effects of isovalerate supplementation on rumen fermentation, urinary excretion of purine derivatives and feed digestibility in the total tract of steers. Eight ruminally cannulated Simmental steers were used in a replicated 4 · 4 Latin square experiment. The treatments were: control (without isovalerate), low isovalerate (LIV), medium isovalerate (MIV) and high isovalerate (HIV) dosage of isovalerate at 100, 200 and 300 mg isovalerate per kg dry matter (DM) intake respectively. Diets consisted of corn stover and concentrate (60/40, DM basis). Dry matter intake was approximately 9 kg per day that was 90% of ad libitum intake including 5.4 kg corn stover and 3.6 kg concentrate. Ruminal pH (6.72–6.54) was linearly (p < 0.03) reduced, whereas total volatile fatty acid concentration (64.6–74.7 mmol/l) was linearly (p < 0.01) and quadratically (p < 0.01) increased with increasing isovalerate supplementation. Ratio of acetate to propionate increased linearly (p < 0.01) from 2.78 to 3.39 as isovalerate supplementation increased because of the increase in acetate production and decrease in propionate production. In situ ruminal degradation of amylase-treated neutral detergent fibre (aNDF) of corn stover was improved, but crude protein (CP) degradability of soybean meal decreased with increasing isovalerate supplementation. Urinary excretion of purine derivatives was quadratically (p < 0.01) changed by altering isovalerate supplementation (50.5, 54.3, 58.9 and 55.2 mmol/day for control, LIV, MIV and HIV, respectively). Similarly, digestibilities of organic matter, aNDF and CP in the total tract were linearly and quadratically increased with increasing isovalerate supplementation. The results of this study indicate that supplementation of diet with isovalerate improved ruminal fermentation and feed digestion in beef cattle. It was suggested that the isovalerate stimulated the digestive microorganisms or enzymes in a dose-dependent manner.
Analysis of a Range of Catabolic Mutants Provides Evidence That Phytanoyl-Coenzyme A Does Not Act as a Substrate of the Electron-Transfer Flavoprotein/Electron-Transfer Flavoprotein:Ubiquinone Oxidoreductase Complex in Arabidopsis during Dark-Induced Senescence1[W][OA]

The process of dark-induced senescence in plants is not fully understood, however, the functional involvement of an electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO), has been demonstrated. Recent studies have revealed that the enzymes isovaleryl-coenzyme A (CoA) dehydrogenase and 2-hydroxyglutarate dehydrogenase act as important electron donors to this complex. In addition both enzymes play a role in the breakdown of cellular carbon storage reserves with isovaleryl-CoA dehydrogenase being involved in degradation of the branched-chain amino acids, phytol, and lysine while 2-hydroxyglutarate dehydrogenase is exclusively involved in lysine degradation. Given that the chlorophyll breakdown intermediate phytanoyl-CoA accumulates dramatically both in knockout mutants of the ETF/ETFQO complex and of isovaleryl-CoA dehydrogenase following growth in extended dark periods we have investigated the direct importance of chlorophyll breakdown for the supply of carbon and electrons during this process. For this purpose we isolated three independent Arabidopsis (Arabidopsis thaliana) knockout mutants of phytanoyl-CoA 2-hydroxylase and grew them under the same extended darkness regime as previously used. Despite the fact that these mutants accumulated phytanoyl-CoA and also 2-hydroxyglutarate they exhibited no morphological changes in comparison to the other mutants previously characterized. These results are consistent with a single entry point of phytol breakdown into the ETF/ETFQO system and furthermore suggest that phytol is not primarily metabolized by this pathway. Furthermore analysis of isovaleryl-CoA dehydrogenase/2-hydroxyglutarate dehydrogenase double mutants generated here suggest that these two enzymes essentially account for the entire electron input via the ETF complex.
Eye movement disorders are different in Parkin-linked and idiopathic early-onset PD

Objectives: Parkin gene mutations are the most common cause of early-onset parkinsonism. Patients with Parkin mutations may be clinically indistinguishable from patients with idiopathic early-onset Parkinson disease (EOPD) without Parkin mutations. Eye movement disorders have been shown to differentiate parkinsonian syndromes, but have never been systematically studied in Parkin mutation carriers. Methods: Eye movements were recorded in symptomatic (n = 9) and asymptomatic Parkin mutation carriers (n = 13), patients with idiopathic EOPD (n = 14), and age-matched control subjects (n = 27) during established oculomotor tasks. Results: Both patients with EOPD and symptomatic Parkin mutation carriers showed hypometric prosaccades toward visual stimuli, as well as deficits in suppressing reflexive saccades toward unintended targets (antisaccade task). When directing gaze toward memorized target positions, patients with EOPD exhibited hypometric saccades, whereas symptomatic Parkin mutation carriers showed normal saccades. In contrast to patients with EOPD, the symptomatic Parkin mutation carriers showed impaired tracking of a moving target (reduced smooth pursuit gain). The asymptomatic Parkin mutation carriers did not differ from healthy control subjects in any of the tasks. Conclusions: Although clinically similarly affected, symptomatic Parkin mutation carriers and patients with idiopathic EOPD differed in several oculomotor tasks. This finding may point to distinct anatomic structures underlying either condition: dysfunctions of cortical areas involved in smooth pursuit (V5, frontal eye field) in Parkin-linked parkinsonism vs greater impairment of basal ganglia circuits in idiopathic Parkinson disease.
Syntaxin 1A Interaction with the Dopamine Transporter Promotes Amphetamine-Induced Dopamine Efflux

The soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein syntaxin 1A (SYN1A) interacts with and regulates the function of transmembrane proteins, including ion channels and neurotransmitter transporters. Here, we define the first 33 amino acids of the N terminus of the dopamine (DA) transporter (DAT) as the site of direct interaction with SYN1A. Amphetamine (AMPH) increases the association of SYN1A with human DAT (hDAT) in a heterologous expression system (hDAT cells) and with native DAT in murine striatal synaptosomes. Immunoprecipitation of DAT from the biotinylated fraction shows that the AMPH-induced increase in DAT/SYN1A association occurs at the plasma membrane. In a superfusion assay of DA efflux, cells overexpressing SYN1A exhibited significantly greater AMPH-induced DA release with respect to control cells. By combining the patch-clamp technique with amperometry, we measured DA release under voltage clamp. At -60 mV, a physiological resting potential, AMPH did not induce DA efflux in hDAT cells and DA neurons. In contrast, perfusion of exogenous SYN1A (3 μM) into the cell with the whole-cell pipette enabled AMPH-induced DA efflux at -60 mV in both hDAT cells and DA neurons. It has been shown recently that Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by AMPH and regulates AMPH-induced DA efflux. Here, we show that AMPH-induced association between DAT and SYN1A requires CaMKII activity and that inhibition of CaMKII blocks the ability of exogenous SYN1A to promote DA efflux. These data suggest that AMPH activation of CaMKII supports DAT/SYN1A association, resulting in a mode of DAT capable of DA efflux.
Los valores de los consumidores y las preferencias en el comportamiento de ir de compras

El �ir de compras� es un fenomeno cada vez mas importante, tanto como actividad de ocio como por ser un sistema para recoger informacion, mantener relaciones sociales o realizar compras. Por otra parte, existe consenso sobre la importante influencia de los valores de los consumidores sobre multitud de aspectos relacionados con el consumo. Sin embargo, no hay referencias academicas que vinculen los valores con las preferencias e intenciones en el �ir de compras�. Utilizando la tecnica de las correlaciones canonicas, este trabajo muestra de forma exploratoria, que los valores de los consumidores tienen una influencia significativa y de interes en las preferencias a la hora de ir de compras. Se muestra la existencia de diferencias significativas en la configuracion de valores cuando se discrimina por sexo y por generacion (mayores vs. jovenes). Tambien que cada perfil muestra una relacion significativa con la preferencia por ir de compras, la preferencia por establecimiento segun su surtido y la intencion de compra. El trabajo concluye con una discusion sobre el significado de estas diferencias y su influencia sobre las politicas comerciales de los establecimientos minoristas. Tambien se presenta un conjunto de futuras lineas de trabajo.
VEGFR‐2 inhibition augments cigarette smoke‐induced oxidative stress and inflammatory responses leading to endothelial dysfunction

Vascular endothelial growth factor (VEGF) induces phosphorylation of VEGF receptor‐2 (VEGFR‐2) and activates the downstream signaling pathway resulting in endothelial cell migration, proliferation, and survival. Cigarette smoking is associated with abnormal vascular and endothelial function, leading to airspace enlargement. Herein, we investigated the mechanism of cigarette smoke (CS) ‐induced endothelial dysfunction by studying the VEGF‐VEGFR‐2 signaling in mouse lung and human endothelial cells. CS exposure caused oxidative stress, as shown by increased levels of 4‐hydroxy‐2‐nonenal‐adducts in mouse lung and reactive oxygen species generation in human lung microvascular endothelial cells (HMVEC‐Ls). Inhibition of VEGFR‐2 by a specific kinase inhibitor (NVP‐AAD777) enhanced the CS‐induced oxidative stress, causing augmented inflammatory cell influx and proinflammatory mediators release in mouse lung. The levels of endothelial nitric oxide synthase (eNOS) and phosphorylated (p) ‐eNOS in the lungs of mice exposed to CS and/or treated with VEGFR‐2 inhibitor were decreased. CS down‐regulated VEGFR‐2 expression, eNOS levels, and VEGF‐induced VEGFR‐2 phosphorylation in HMVEC‐Ls, resulting in impaired VEGF‐induced endothelial cell migration and angiogenesis. Overall, these data show that inhibition of VEGFR‐2 augmented CS‐induced oxidative stress and inflammatory responses leading to endothelial dysfunction. This explains the mechanism of endothelial dysfunction in smokers and has implications in understanding the pathogenesis of pulmonary and cardiovascular diseases. —Edirisinghe, I. , Yang, S. ‐E. , Yao, H. , Rajendrasozhan, S. , Caito, S. , Adenuga, D. , Wong, C. , Rahman, A. , Phipps, R. P., Jin, Z. ‐G. , Rahman, I. VEGFR‐2 inhibition augments cigarette smoke‐induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J. 22, 2297–2310 (2008)
The Burden of Secrecy Among South African Adolescents Orphaned By HIV And AIDS

HIV thrives in an atmosphere of silence and secrecy. The stigma, real or feared, of HIV/AIDS is often a barrier to support and care that adolescent orphans need. The purpose of this article is to describe the burden of silence borne by adolescents orphaned by HIV and AIDS. A phenomenological study using photography and photo-elicitation was done among orphaned adolescents. Fifteen adolescents orphaned by HIV and AIDS, living in an urban area of South Africa, participated in the study. Participants photographed objects, such as graveyards, hearses, and a room where a parent committed suicide. These photographed objects were grouped as symbols of death. Nature and people also were photographed. Photo-elicitation revealed the psychosocial impact that results from the secrecy about parental cause of death. Implications for mental health practitioners are also discussed.
An Efficient Procedure for Bilayer-Expurgated LDPC Codes Design in Cooperative Relay Channels

This letter proposes a fast optimization procedure to design bilayer-expurgated low density parity check codes in the relay channel. The code optimization problem aims to maximize the code rate while guaranteeing the convergence of the density evolution relations in upper and lower layer codes. The original problem is linear programming. Nevertheless, it suffers from high computational complexity, as it is semi-infinite programming (SIP) in a 2-D continuous interval. To efficiently solve it, we first approximate the density evolutions by polynomials. Then, leveraging optimization problems over the solution of sum of square multivariate polynomials the problem is transformed to semi-definite programming (SDP), where the global solution can be found efficiently using available SDP solvers. Our simulation shows that our approach results in significantly lower computational complexity with respect to the well-known method of quantization for solving the SIP problem, while both achieve the same performance.
Cognitive vulnerability in patients with bipolar disorder

Background. No study has simultaneously explored key components of Beck's model of cognitive vulnerability to depression in people with bipolar disorders. Methods. We compared 41 euthymic bipolar patients with 20 healthy control subjects. All subjects were assessed on the Hamilton Rating Scale for Depression, the Autobiographical Memory Test and the Mean Ends Problem-Solving procedure and also completed the Beck Depression Inventory, the Dysfunctional Attitude Scale, the Sociotropy Autonomy Scale and the Rosenberg Self-Esteem Questionnaire. Results. In comparison to control subjects, patients with bipolar disorder demonstrated significantly higher levels of dysfunctional attitudes (particularly perfectionism and need for approval) and sociotropy, significantly greater over-general recall on an autobiographical memory test and significantly less ability to generate solutions to social problem-solving tasks. These between group differences remained significant when age, intelligence, latency to respond to autobiographical memory test cue words, and subjective mood ratings were included as co-variates in the statistical analysis. Within the patient group, cognitive dysfunction was significantly correlated with level of morbidity (as measured by number of previous illness episodes). Conclusions. This study suggests that cognitive vulnerability in patients with bipolar disorder is similar to that described in unipolar disorders. It is not clear whether this dysfunction is a cause or an effect of repeated episodes of bipolar disorder. However, the findings may have implications for clinical treatment as well as suggesting a number of important new avenues of research into psychological models of affective disorder.