Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic stromal and immune response expression patterns in early-stage colorectal cancer predicted by genes intrinsically expressed by tumor epithelial cells.

3601 Background: High stromal content (CMS4) and immune infiltration (CMS1) are important features of the tumor micro-environment (TME) in early stage colorectal cancer, with poor and good RFS prognosis, respectively. However, it remains unclear how these TME features are influenced by intrinsic tumor epithelial expression profiles. We examined how the former can be predicted by the latter, and assessed their respective prognostic contributions. Methods: Eighteen public gene-expression datasets (n=3511) were used for discovery, and an adjuvant trial dataset (PETACC3 n=688) was used for validation. Whole-transcriptome hierarchical clustering was applied to identify intrinsic versus extrinsic co-expression modules, corroborated by single-cell profiling data. The epithelial gene subset were used to predict previously assigned CMS labels, producing new CRC classifier that we refer to as epithelial-CMS (eCMS). Results: Despite lacking stromal and immune response genes, eCMS predicted CMS with an accuracy of 82% [CI 78-85%] in the test dataset. Not only were the RFS prognostic values retained (eCMS1 vs non-eCMS1: HR=0.59 [CI 0.35–0.95, p=0.029], and eCMS4 vs non-e-CMS4: HR=1.82 [CI 1.38–2.41, p=0.0003]), but they were also significantly improved when compared to the original CMS classification (CMS1 vs non-CMS1: HR=0.76 [CI 0.49–1.16, p=0.2] and CMS4 vs non-CMS4: HR=1.43 [CI 1.07–1.91, p=0.017]. In a multivariable regression comparison, eCMS was superior to CMS (p=0.001 vs p=0.36). Each eCMS group was associated with specific combinations of up- and down-regulation of CRC-relevant pathways, such as CDX2, map-kinase, mucin secretion, DNA damage repair and cell proliferation. Conclusions: Stromal and immune infiltration patterns in the TME are strongly associated with tumor epithelial expression profiles, as captured by eCMS. This finding sheds new light on the interplay between intrinsic molecular features of CRCs and their TME, and illuminates new paths for potential combination therapies.
AB0614 Infection and Disease Activity in a Cohort of Egyptian Systemic Lupus Erythematosus Patients

Background Infections are among the most important causes of morbidity and mortality in SLE patients [1]. Despite the availability of newer therapeutic measures to improve clinical outcome in SLE patients, the incidence of infections as a cause of morbidity and mortality has not changed over the past 30 years [2], and infection is still considered as one of the leading causes of morbidity and mortality in SLE patients [3]. Infection is responsible for approximately 25% of all deaths in patients with SLE, making it a leading cause of mortality in SLE [4]. Objectives To determine the prevalence of infections, to describe their sites, relation of infection to disease activity in this group of Egyptian Systemic lupus erythematosus (SLE) patients. Methods Medical records of 175 Systemic lupus erythematosus (SLE) patients attending the Rheumatology & Rehabilitation Department, Cairo University hospital were reviewed retrospectively for the demographic information, clinical features of the disease, immune profile, laboratory features, systemic lupus erythematosus disease activity index (SLEDAI) and medical treatment with special reference to the relation of infection to disease activity in this group of Egyptian SLE patients. All of the patients fulfilled the updated American College of Rheumatology (ACR) revised criteria for the classification of SLE. Results 87 patients (49.71%), experienced infection. The most common site of infection was the skin in 36% then UTI in 22%, chest in 15%. Highly significant statistical difference was found between infection and non infection group regarding (SLEDAI) P<0.001 (after regression analysis P=0.000). Conclusions Disease activity is an important risk factor for infection in SLE patients. References Ruiz-Irastorza G, Olivares N, Ruiz-Arruza I, et al. Predictors of major infections in systemic lupus erythematosus. Arthritis Res Ther. 2009;11(4):R109. doi: 10.1186/ar2764. Epub 2009 Jul 15. Enberg G M, Kahn Ch M, Goity FC, et al. Infections in patients with Systemic Lupus Erythematosus. Rev Med Chil. 2009 Oct;137(10):1367-74. Sciascia S, Ceberio L, Garcia-Fernandez C, et al. Systemic lupus erythematosus and infections: Clinical importance of conventional and upcoming biomarkers. Autoimmun Rev. 2012 Dec;12(2):157-63. doi: 10.1016/j.autrev. 2012.03. 009. Epub 2012 Apr 1. Kamen DL. How can we reduce the risk of serious infection for patients with systemic lupus erythematosus? Arthritis Res Ther. 2009;11(5):129. Disclosure of Interest None declared
Website Vulnerability to Session Fixation Attacks

Session fixation is a vulnerability of web applications where a malicious attacker gains full control of a victim’s web account without having to use the victim’s credentials such as username and password. Extant defensive techniques and procedures are not completely effective against such attacks. The authors found that some 48% of Indonesian websites are vulnerable to such attacks because, contrary to best software engineering practices, many use default session management IDs generated by their development platforms. This paper presents procedures for identifying vulnerable websites and the results. Keywords: web application security; session fixation; session hijacking
Pantomath: College Inquiry Chatbot

: The ‘Pantomath Chatbot’ is a college inquiry chatbot which is built using Natural Language Processing (NLP) that analyses and understand user’s message. This system is a website which provides an answer to the query of the user [1] . The user can chat using appropriate Standard English. The chatbot uses intent based analysis to answer the query. The system replies to the user as if a real person is interacting with the user. The user can query college-related activities such as date and timing of annual day, sports day, and other cultural activities, results, the location of a class or lab. Pantomath provides a text-based user interface, allowing the user to type questions and receive text as well as voice response.
Physiology, Arterial Pressure Regulation

In general, an individual’s “blood pressure,” or systemic arterial pressure, refers to the pressure measured within large arteries in the systemic circulation. This number splits into systolic blood pressure and diastolic blood pressure. Blood pressure is traditionally measured using auscultation with a mercury-tube sphygmomanometer. It is measured in millimeters of mercury and expressed in terms of systolic pressure over diastolic pressure. Systolic pressure refers to the maximum pressure within the large arteries when the heart muscle contracts to propel blood through the body. Diastolic pressure describes the lowest pressure within the large arteries during heart muscle relaxation between beating. Arterial pressure directly corresponds to cardiac output, arterial elasticity, and peripheral vascular resistance. Blood pressure is remarkably easy to alter and can be affected by many activities. Maintaining blood pressure within normal limits is essential. A blood pressure between 140/80 mmHg to 159/99 mmHg is classified to as stage 1 hypertension. Categorization of Stage 2 hypertension is a pressure between 160/100 mmHg to 179/109 mmHg. Hypertensive urgency describes a blood pressure greater than 180/110 mmHg and hypertensive emergency refers to a very high blood pressure that results in potentially life-threatening symptoms and end-organ damage. Hypotension, on the other hand, is a blood pressure less than 90/60 mmHg. It is crucial for the body to be able to adjust to acute changes in blood pressure and for the patient to receive medical treatment or lifestyle adjustments for chronic variations.
Core stability and exercise prescription: a research update: implications for physiotherapists

Physiotherapists frequently prescribe exercises to improve core stability. These exercises aim to improve the capacity (strength, power, endurance) and/or control of lumbopelvic muscles and are generally based on the premise that improving core stability can improve movement efficiency and reduce lumbopelvic and lower leg injury. (author abstract)
Assessment of platelets in patients with pulmonary hypertension

Background: Pulmonary hypertension (PH) occurs due to end result of multifactorial etiology causing significant morbidity and mortality. Platelets are observed to be activated during initiation and progression of disease, platelets indices used as surrogate markers for platelet activation was used in current study to investigate effect of PH on platelets and correlate it with severity of PH.Methods: 104 patients with PH were grouped according to WHO classification depending upon etiology. Blood samples of patients from all groups were collected and investigated for platelet indices, peripheral smear, bleeding time, clotting time and echocardiography assessment to know the severity of pulmonary hypertension. Patients were reviewed after 2 months of appropriate treatment.Results: Prevalence of PH due to chronic lung disease (48.1%) was the most common observation. Thrombocyte count was decreased significantly in all groups of PH with p<0.01. MPV, PDW, P-LCR (platelet-large cell ratio) were observed to be increased with increasing severity for PH. Significant correlation p=0.01 indicated that platelet indices were altered with treatment for PH.Conclusions: Significant reduction was observed in platelet count with increase in platelet indices can be correlated with severity of PH. Hence in rural areas without echo cardiogram facilities, platelet indices can be considered as surrogate markers for early referral of patients to higher centers for further management of PH.
A Semi-Automatic Depth Estimation Method for FTV

In this paper, we propose a semi-automatic depth estimation algorithm for Free-viewpoint TV (FTV). The proposed method is an extension of an automatic depth estimation method whereby additional manually created data is input for one or multiple frames. Automatic depth estimation methods generally have difficulty obtaining good depth results around object edges and in areas with low texture. The goal of our method is to improve the depth in these areas and reduce view synthesis artifacts in Depth Image Based Rendering. High-quality view synthesis is very important in applications such as FTV and 3DTV. We define three types of manual input data providing disparity initialization, object segmentation information, and motion information. This data is input as images, which we refer to as manual disparity map, manual edge map, and manual static map, respectively. For evaluation, we used MPEG multi-view videos to demonstrate that our algorithm can significantly improve the depth maps and, as a result, reduce view synthesis artifacts.
American Chestnut: The Life, Death, and Rebirth of a Perfect Tree

Map of American chestnut distribution in 1938 Introduction PART ONE 1. Where There Are Chestnuts 2. A New Scourge 3. Let Us Not Talk about Impossibilities 4. A Whole World Dying PART TWO 5. Rolling the Dice 6. Evil Tendencies Cancel 7. Let Us Plant 8. Chestnut 2.0 9. Faith in a Seed Conclusion / The Comeback Notes Acknowledgments Index
Pancreatitis aguda recidivante como forma de presentación de fibrosis quística

Resumen La fibrosis quistica (FQ) es una enfermedad multiorganica autosomica recesiva consecuencia de mutaciones existentes en un gen del brazo largo del cromosoma 7. La mayor parte de los casos se diagnostica durante los primeros anos de vida, cuando la enfermedad se presenta de forma tipica con manifestaciones pulmonares graves e insuficiencia pancreatica, pero un pequeno porcentaje de pacientes no se diagnostica hasta la adolescencia e incluso la edad adulta, por presentar cuadros clinicos menos floridos. El genotipo de cada paciente parece influir en las diferentes formas clinicas de presentacion de la enfermedad. La pancreatitis aguda recidivante, aunque poco frecuente, puede ser una de las formas de presentacion tardia de la FQ. Presentamos el caso de un varon de 17 anos que fue diagnosticado de FQ tras presentar 2 episodios de pancreatitis aguda, sin insuficiencia pancreatica asociada. Tambien se detectaron en el estudio posterior polipos nasales.
Probable Effects of Dual Inoculation of Maize (Zea mays) Stem with Fusarium verticillioides and Certain Trichoderma Species on Fumonisin Content of Maize Seeds

Seeds from maize (Z. mays) plants whose stems received various treatment combinations of pathogen (F. verticillioides) and four antagonists (i.e. Trichoderma harzianum strain 2, T. hamatum, T. pseudokoningii strains 2 and 5) in the field were subjected to fumonisin analysis. Three pairing methods were employed for the inoculation of pathogen and the antagonists into stem of the maize plant, viz., “Pathogen inoculated before Antagonist”, “Antagonist inoculated before Pathogen”, and “Antagonist and Pathogen inoculated simultaneously”. Controls include “Inoculation of pathogen alone”, “Inoculation of antagonist alone”, and “Inoculation of sterile toothpicks”. Inoculation method used was the toothpick method. Seeds were harvested five weeks after inoculation and subjected to fumonisin analysis. Resulting data were subjected to ANOVA using the GLM procedure of SAS. There was a high significance among treatments i.e. there were varying levels of fumonisin occurrence among the treatments and varying Fusarium occurrences within the blocks. Seeds from treatments involving “Inoculating T. pseudokoningii strain 5 alone” and “Inoculating T. harzianum strain 2 alone” had the highest mean fumonisin content (P > 0.01) which were not significantly higher than in control. Seeds from treatments involving “Inoculating T. pseudokoningii strain 5 and pathogen simultaneously” and “Inoculating T. harzianum strain 2 before pathogen” were significantly low in fumonisin content compared to seeds from other treatments. Seeds which received “Inoculation of T. hamatum alone” were also significantly low (P > 0.01) in fumonisin content compared to others. It could thus be said that treatments involving Trichoderma species applied in the maize stem might have an effect on the fumonisin content and hence Fusarium occurrence in the seeds depending on the occurrence pattern of the Trichoderma within the maize stem.
Direct Torque Control によるSRMの低トルクリプル速度制御

Switched reluctance motors (SRMs) have several desirable features, including simple construction, high reliability, and low cost. However, one of their drawbacks is higher torque ripple. Direct torque control (DTC) is considered a useful way of controlling the torque ripple. This paper presents an approach to the design and implementation of direct torque controller for SRM using digital signal processor (DSP) and field programmable gate arrays (FPGAs).
IS042 Augmentation of Postnatal Neovascularization by Transplantation of Cord Blood-derived Endothelial Progenitor Cells

Thrombomodulin is an important endothelial anticoagulant protein that decreases thrombin activity and activates protein C. Our recent study has shown that the G-33A promoter mutation of thrombomodulin gene is associated with coronary artery disease. This study was conducted to determine whether the G-33A mutation in the promoter region of thrombomodulin gene is a genetic risk factor for ischemic stroke or carotid atherosclerosis. The functional significance of this mutation was also evaluated. We recruited 333 patients (mean age 64 years, 59% male) with ischemic stroke and 257 age- and sex-matched controls. In all study participants, carotid atherosclerosis was assessed by Duplex scanning, and thrombomodulin G-33A promoter mutation was detected by single-strand conformation polymorphism. Luciferase reporter gene assay was used to assess the influence of this mutation on thrombomodulin promoter activity. There was no significant difference in the thrombomodulin G-33A mutation frequency (GAAA genotypes) between the stroke and the control groups (18.3 vs. 24. 1%, P 0.105). The G-33A mutation frequency was also similar between the study participants with and without carotid atherosclerosis (22.2 vs. 19.8%, P0.550). When only younger subjects (age 560 years) were included in the analysis, however, we found the mutation occurred more frequently in participants with carotid atherosclerosis (33.3 vs. 17.3%, odds ratio [OR] 2.38, 95% confidence interval [CI] 1.16‐4.90, P0.027). Multiple logistic regression analyses showed that only diabetes mellitus (OR 3.11, 95% CI 1.33‐7.30, P0.009) and G-33A mutation (OR2.46, 95% CI 1.14‐5.29, P 0.021) were associated independently with carotid atherosclerosis in younger subjects. As assessed by luciferase reporter gene assays, the contructs bearing the G-33A mutation showed a significant decrease (36912%) in transcriptional activity in comparison with the wild type constructs. Our findings suggest that G-33A mutation reduces the thrombomodulin promoter activity and is associated with carotid atherosclerosis in younger subjects. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Factores de riesgo en las lesiones premalignas y malignas del complejo bucal

Se realizo un estudio analitico y observacional de caso-control no pareado que abarco 400 personas; 100 de ellas con lesiones premalignas y malignas de la cavidad bucal (casos), diagnosticadas histopatologicamente en el periodo comprendido desde enero hasta junio de 1994, y las 300 restantes sin lesiones (controles). A todas se les aplico un cuestionario mediante entrevista individual para identificar si hubo algunos factores de riesgo asociados, y se comprobo que el uso de protesis dental fue el que predomino de todos los factores que se analizaron.
Suitability of Chrysophyllum albidum from moist semi-deciduous forest in Ghana as a raw material for manufacturing paper-based products

ABSTRACT The global demand for paper-based products continues to increase amidst challenges with raw material supply to the pulp industries. Considerable efforts to discover new wood resources from tropical forests to widen the material stock are ongoing. This study examined the suitability of the outer and inner wood fibres from different axial sections (i.e., butt, middle and top) of Chrysophyllum albidum from a moist semi-deciduous forest in Ghana for paper production. The fibre morphology and derived indices [i.e., Runkel Ratio, Slenderness Ratio, Flexibility Coefficient, Coefficient of Rigidity, Luce’s Shape Factor and Solids Factor] were determined using the methods by the International Association of Wood Anatomist. C. albidum inner and outer wood fibres were generally long and thin with wide lumen. The fibre-derived indices were similar to those of many popular paper-producing timbers such as Acacia mangium and Pinus sylvestris. The fibre morphology and derived indices of C. albidum meet the recommended thresholds for fibres for manufacturing writing and printing papers with good tearing and bursting strength properties. Thus, the wood’s fibres would be suitable for producing papers with good strength properties. Its utilization will contribute to expanding the raw material sources for the pulp and paper industry.
Artemisia (Asteraceae) essential oils: compositional variation and mechanisms of its origin, biosynthesis of constituents, correspondence between biological activities and ethnomedicinal usage and repurposement prospects

Artemisia (Asteraceae) Essential Oils: Compositional Variation and Mechanisms of Its Origin, Biosynthesis of Constituents, Correspondence Between B io log i ca l Ac t iv i t i e s and Ethnomedic ina l Usage and Repurposement Prospects RICHA GOEL, VIJENDER SINGH, RAJ KUMARI, RENU KUMARI, SUCHI SRIVASTAVA, GOPAL RAO MALLAVARAPU, DIVYA GOEL and SUSHIL KUMAR Department of Pharmacognosy, KIET School of Pharmacy, Ghaziabad 201 206, India School of Pharmacy, Sharda University, Greater Noida 201 306, UP, India Department of Pharmacognosy, ITS College of Pharmacy, Ghaziabad 201 206, UP, India National Institute of Plant Genome Research (NIPGR), Aruna Asaf Ali Marg, New Delhi 110 067, India; Division of Plant Microbe Interactions, CSIR-National Botanical Research Institute (NBRI), Lucknow 226 001, India; A602, Rennaisance, Yeshwantpur, Bangalore 560 022, India; SKA Institution for Research Education and Development, 4/11 Sarv Priya Vihar, New Delhi 110 016; Integrated Institute of Technology (IIT), Sector 9, Dwarka, New Delhi 110 077, India
Advancements in Canadian Biomaterials Research in Neurotraumatic Diagnosis and Therapies

Development of biomaterials for the diagnosis and treatment of neurotraumatic ailments has been significantly advanced with our deepened knowledge of the pathophysiology of neurotrauma. Canadian research in the fields of biomaterial-based contrast agents, non-invasive axonal tracing, non-invasive scaffold imaging, scaffold patterning, 3D printed scaffolds, and drug delivery are conquering barriers to patient diagnosis and treatment for traumatic injuries to the nervous system. This review highlights some of the highly interdisciplinary Canadian research in biomaterials with a focus on neurotrauma applications.
Droplet and Vapor Drift from Butyl Ester and Dimethylamine Salt of 2,4-D

The relative drift of droplet and vapor of butyl ester and dimethylamine formulations of (2,4-dichlorophenoxy)acetic acid (2,4-D) was determined under conventional crop spraying procedures in the field. Labelled herbicides were mixed with spray solution or emulsion, and the ground deposit and the air-borne droplet and vapor clouds drifting from the target area were collected. The mass of the dimethylamine formulation drifting as droplets was 3 to 4% of the material sprayed. No significant amounts of this material were collected as vapor or particulate drift. For the butyl ester, in addition to the droplet drift, 25 to 30% of the material was collected as vapor drift in the half hour after spraying. Thus the drift potential from the butyl ester was about 8 to 10 times greater than that from the dimethylamine formulation under the conditions of these tests.