Miracle-dz/UniFAR-FTUs huggingface dataset:
Microenvironmental changes by placenta-derived mesenchymal stem cells restore the ovarian function in ovariectomized rat via activated PI3K-FOXO3 pathway

Background: Translational studies have explored the therapeutic potential and feasibility of mesenchymal stem cells (MSCs) in several degenerative diseases; however, the mechanistic studies of the function of these cells have been insufficient. As ovarian failures cause anovulation as well as ovarian steroid hormonal unbalances, the specific aims of this study were to analyze the therapeutic role of placenta derived MSCs (PD-MSCs) in an ovarian-failure ovariectomy (OVX) rat model and evaluate whether PD-MSCs transplantation (Tx) improved folliculogenesis and oocyte maturation in the injured ovary through PI3K/Akt and FOXO signaling. Methods: Blood and ovary tissue were collected and analyzed after various PD-MSCs Tx treatments in the ovariectomized rat model. Changes in the expression of folliculogenesis and ovary regeneration-related genes due to PD-MSCs treatments were analyzed by qRT-PCR, Western blotting, and histological analysis. Results: The levels of hormones related to ovary function were significantly increased in the PD-MSCs Tx groups compared with those of the non-transplantation group (NTx). The follicle numbers in the ovarian tissues were increased along with increased expression of genes related to folliculogenesis for PD-MSCs Tx compared with NTx groups. Furthermore, PD-MSCs Tx induced maturation of follicles by increasing the phosphorylation of GSK3 beta and FOXO3 (p<0.05) and shifting the balance of growth and apoptosis in the oocytes. Conclusions: Taken together, PD-MSCs Tx can restore the ovarian function as well as induce ovarian folliculogenesis via the PI3K/Akt and FOXO signaling pathway.
Elevated Iron Chelating Activity of Ilex paraguariensis Leaf Infusion: in vitro and in vivo Pilot Studies

This study presents an Ilex paraguariensis leaf infusion with important potential as natural ironchelating. The impact of infusion time and the water volume to obtain an Ilex paraguariensis leaf infusion with high phenolic content and iron chelating activity, such as the stability of these proprieties in the storage time and temperature (immediately and after 24 h at 8 and 25 C) were assessed. The acute consumption effect of this infusion to reduce iron absorption in vivo was also evaluated. A preliminary crossover trial with volunteers that ingested a meal containing non-haem iron (11.4 mg) with the treatments: Ilex paraguariensis leaf infusion with the highest phenolic content and iron chelating activity (200 mL) or control (200 mL water). Blood samples were withdrawn before and 1, 2, 3 and 4 h after the meal for serum iron measurement. The highest phenolic content (18.1 mg/mL) and iron chelating activity (100%) were observed for 10 min infusion time using 30 g leaves/300 mL water. Storage at 8 or 25 C for 24 h decreased total phenolics and dicaffeoylquinic acids by 23.5% and 25.5%, respectively (p< 0.05), without affecting the iron-chelating activity due to a saturating chelating effect at 3.34 mg/mL phenolic content. Inhibition of the iron absorption in vivo by infusion was 78% considering the iron recovery at peak maximum. The in vitro and preliminary in vivo results showed a functional property of the Ilex paraguariensis leaf infusion that may be useful for adjuvant management of iron overload diseases.
Enhancement of Sentiment Analysis Using Clause and Discourse Connectives

: The sentiment of a text depends on the clausal structure of the sentence and the connectives’ discourse arguments. In this work, the clause boundary, discourse argument, and syntactic and semantic information of the sentence are used to assign the text’s sentiment. The clause boundaries identify the span of the text, and the discourse connectives identify the arguments. Since the lexicon-based analysis of traditional sentiment analysis gives the wrong sentiment of the sentence, a deeper-level semantic analysis is required for the correct analysis of sentiments. Hence, in this study, explicit connectives in Malayalam are considered to identify the discourse arguments. A supervised method, conditional random fields, is used to identify the clause boundary and discourse arguments. For the study, 1,000 sentiment sentences from Malayalam documents were analyzed. Experimental results show that the discourse structure integration considerably improves sentiment analysis performance from the baseline system.
Prevalence of cardiovascular disease risk factors and long-term outcomes in the Saudi population: Results from the Prospective Urban Rural Epidemiology study (PURE-Saudi)

Objective We report the prevalence of unhealthy lifestyle behaviors, cardiovascular disease (CVD) risk factors, and long-term outcomes within the Saudi population, stratified by age, sex, and place of residence. Methods The Prospective Urban Rural Epidemiology (PURE) study is a global cohort study including adults of 35–70 years old in 20 countries. PURE-Saudi study participants were recruited from 19 urban and 6 rural communities randomly selected from the Central province (Riyadh and Alkharj) between February 2012 and January 2015. Clinical follow-up of major CVD events and mortality is ongoing. Results The PURE-Saudi study enrolled 2047 participants (mean age, 46.5 ± 9.12 years; 43.1% women; 24.5% rural ). Overall, 69.4% had low physical activity, 49.6% obesity, 34.4% unhealthy diet, 32.1% dyslipidemia, 30.3% hypertension, 25.1% diabetes, 12.2% were current smokers, 15.4% self-reported feeling sad, 16.9% had history of stress (several periods), 6.8% had permanent stress, 0.98% had history of stroke, 0.64% had heart failure, and 2.5% had coronary heart disease (CHD). Compared to women, men were more likely to be current smokers (21% vs. 0.45%, p<0.001), have diabetes (28.2% vs. 21.3%, p<0.001), and have history of CHD (3.2% vs. 1.6%, p=0.02); while women were more likely to be obese (58.6% vs. 42.8%, p<0.001), have central obesity (70.7% vs. 32.7%, p<0.001), self-report sadness (22.7%, vs. 9.9% p<0.001), experience stress (several periods), feel permanent stress (9.9% vs. 4.5%, p<0.001), and have low education (46.6% vs. 20.2%, p<0.001). Compared to participants in urban areas, those in rural areas had higher rates of diabetes (31.1% vs. 23.3%, p<0.001), obesity (56.6% vs. 47.3%, p<0.001), and hypertension (35.5% vs. 28.6%, p=0.004); and lower rates of unhealthy diet, self-reported sadness, stress (several periods), and permanent stress. Compared to middle- and old-age individuals, younger participants more commonly reported unhealthy diet, permanent stress, and self-reporting of being sad. Conclusion PURE-Saudi, the first population cohort study in Saudi Arabia, revealed a high prevalence of CVD risk factors in the adult Saudi population, with higher rates in rural than urban areas. National public awareness programs and multi-faceted healthcare policy changes are urgently needed to reduce the burden of CVD risk and mortality.
Enhancing Investigative Pattern Detection via Inexact Matching and Graph Databases

Tracking individuals or groups based on their hidden and/or emergent behaviors is an indispensable task in homeland security, mental health evaluation, and consumer analytics. On-line and off-line communication patterns, behavior profiles and social relationships form complex dynamic evolving knowledge graphs. Investigative search involves capturing and mining such large-scale knowledge graphs for emergent profiles of interest. While graph databases facilitate efficient and scalable operations on complex heterogeneous graphs, dealing with incomplete, missing and/or inconsistent information and need for adaptive querying pose major challenges. We address these by proposing an inexact graph pattern matching method, which is implemented in a graph database with a scoring mechanism that helps identify hidden behavioral patterns. PINGS (Procedures for INvestigative Graph Search), a graph database library of procedures for investigative graph search is presented. Results presented demonstrate the capability of detecting individuals/groups meeting query criteria as well as the iterative query performance in graph databases. We evaluate our approach on three datasets: a synthetically generated radicalization dataset, a publicly available patient’s ICU hospitalization stays dataset, and a crime dataset. These varied datasets demonstrate the wide-range applicability and the enhanced effectiveness of observing suspicious or latent trends in investigative domains.
Inventory Management Practices in Private Healthcare Facilities in Nairobi County

Universal health coverage (UHC) is an integral part of the United Nations sustainable development goals. The private sector plays a prominent role in achieving UHC, being the primary source of essential medicines for many people. However, many private healthcare facilities in low‐ and middle‐income countries (LMICs) have insufficient stocks of essential medicines. Simultaneously, these same facilities carry excessive quantities of other drugs, leading to obsolescence. This suggests poor inventory control. To propose potential remedies it is vital to fully understand the underlying causes. In semi‐structured interviews with managers of private healthcare facilities in Nairobi, we asked them about their (1) inventory control systems, (2) inventory control skills, (3) time/human resource constraints, (4) budget constraints, (5) motivations for inventory control, and (6) suppliers. Our results suggest that the problems are driven by resource limitations (budget and time/human resources), managerial issues (relating to skills and systems), and market mechanisms that limit overage and underage costs. Unavailability at the supplier level and motivations for inventory control are relatively minor issues. We posit that the key causes are interlinked and stem from wider issues in the market and regulatory environment. Our results challenge prevalent beliefs about medicine supply chains in LMICs and lead to novel hypotheses. Testing these hypotheses could improve our understanding of inventory management in private healthcare facilities and aid progress in achieving UHC.
Isomerization and Evaporation of Red Sorghum Hydrolyzate Sugar into Fructose Syrup through Water and Ethanol-Water as the Media

Red sorghum flour has considerable potential to be used as fructose syrup. The process of making fructose syrup was started with making hydrolyzate sugar by enzymatic hydrolysis of the polysaccharide into glucose syrup, then being isomerized using glucose-isomerase into fructose syrup. The study aimed to determine the best temperature in the isomerization process of hydrolyzate sugar from red sorghum flour through water and ethanol-water as the media and determine the optimum temperature of evaporation process to produce fructose syrup appropriate with SNI and HFS 42 commercials products. Isomerization was carried out on water media and ethanol-water media (2.5: 1) with temperature variations of 27 °C, 40 °C and 60 °C, with a total volume of 100 mL, for 43 hours, and enzyme concentration 1% (b/v) while the evaporation process was carried out at a pressure of 0.8 atm with a temperature variations of 55 °C, 60 °C, 75 °C, and a total volume of 30 ml. The best results of the isomerization process was obtained at 60 °C by water media with the concentration of fructose of 71.60 g/L and the evaporation process at 60 °C obtained an increase in fructose concentration by 70 % from initial fructose concentration and viscosity of 1.60 poise.
Orientación y coevaluación: Dos aspectos clave para la evolución del proceso de resolución de problemas

This study aims at comparing and describing the different development phases in a non-linear orientation base elaborated by 25 students in sixth grade when they solve four pattern mathematical problems. A qualitative analysis of the items that appear in the different phases of development in the non-linear orientation base is done based on the students’ productions and peer assessment questionnaires that serve as a feedback method. Our results emphasize that, from one phase to another, the non-linear orientation base undergoes through changes in terms of planning, reviewing, and explaining the resolution process that help students verbalize in a more comprehensive way both, the resolution method and the metacognitive processes carried out.
Tannins and Related Polyphenols of Euphorbiaceous Plants. VIII. Eumaculin A and Eusupinin A, and Accompanying Polyphenols from Euphorbia maculata L. and E. Supina RAFIN.

Two new dimeric hydrolyzable tannins named eumaculin A (1) and eusupinin A (2) have been isolated from Euphorbia maculata L. and Euphorbia supina RAFIN. , and their structures elucidated. Twelve other polyphenolic compounds including five hydrolyzable tannins and five flavonol glycosides have also been isolated.
Neural Network-Based Model Reference Control of Braking Electric Vehicles

The problem of energy recovery in braking of an electric vehicle is solved here, which ensures high quality blended deceleration using electrical and friction brakes. A model reference controller is offered, capable to meet the conflicting requirements of intensive and gradual braking scenarios at changing road surfaces. In this study, the neural network controller provides torque gradient control without a tire model, resulting in the return of maximal energy to the hybrid energy storage during braking. The torque allocation algorithm determines how to share the driver’s request between the friction and electrical brakes in such a way as to enable regeneration for all braking modes, except when the battery state of charge and voltage levels are saturated, and a solo friction brake has to be used. The simulation demonstrates the effectiveness of the proposed coupled two-layer neural network capable of capturing various dynamic behaviors that could not be included in the simplified physics-based model. A comparison of the simulation and experimental results demonstrates that the velocity, slip, and torque responses confirm the proper car performance, while the system successfully copes with the strong nonlinearity and instability of the vehicle dynamics.
Photoluminescence and electroluminescence imaging of perovskite solar cells

Fast camera‐based luminescence‐imaging measurements on perovskite solar cells are presented. The fundamental correlation between the luminescence intensity and the open circuit voltage predicted by the generalised Planck law is confirmed, enabling various quantitative methods for the detection of efficiency‐limiting defects to be applied to this new cell structure. Interstinegly, it is found that this fundamental correlation is valid only for light‐soaked devices. Copyright © 2015 John Wiley & Sons, Ltd.
MEASUREMENT OF THE LOWEST MILLIMETER-WAVE TRANSITION FREQUENCY OF THE CH RADICAL

The CH radical offers a sensitive way to test the hypothesis that fundamental constants measured on earth may differ from those observed in other parts of the universe. The starting point for such a comparison is to have accurate laboratory frequencies. Here, we measure the frequency of the lowest millimeter-wave transition of CH, near 535 GHz, with an accuracy of 0.6 kHz. This improves the uncertainty by roughly two orders of magnitude over previous determinations and opens the way for sensitive new tests of varying constants.
Adaptive accumulation and diagnostic information systems of enterprises in energy and industry sectors

Our paper describes the methodology of an effective system construction based on information systems self-diagnosis using the case of Ukrainian enterprises in metallurgy, energy, and chemical industry. It describes the method of organization and implementation of self-diagnosis, mechanisms of detection, as well as the identification and localization of failed modules. The results formulate the criteria of sufficiency of efficiency of diagnostic information in the absence of restrictions on performance of elementary checks. Moreover, it yields the criterion of sufficiency of diagnostic information in the presence of restrictions on performance of elementary checks.
Electron microscopy contribution in the comprehension of interaction mechanisms between nanoparticles and biological cells

Over the last few decades, nanoparticles have been studied in theranostic field with the objective of exhibiting a long circulation time through the body coupled to major accumulation in tumor tissues, rapid elimination, therapeutic potential and contrast properties. In this context, we developed sub-5 nm gadolinium-based nanoparticles that possess in vitro efficient radiosensitizing effects at moderate concentration when incubated with head and neck squamous cell carcinoma cells (SQ20B). Two main cellular internalization mechanisms were evidenced and quantified: passive diffusion and macro- pinocytosis. Whereas the amount of particles internalized by passive diffusion is not sufficient to induce in vitro a significant radiosensitizing effect, the cellular uptake by macropinocytosis leads to a successful radiotherapy in a limited range of particles incubation concentration. Macropinocytosis processes in two steps: formation of agglomerates at vicinity of the cell followed by their collect via the lamellipodia (i.e. the “arms”) of the cell. The first step is strongly dependent on the physicochemical characteristics of the particles, especially their zeta potential that determines the size of the agglomerates and their distance from the cell. These results should permit to control the quantity of particles internalized in the cell cytoplasm, promising ambitious opportunities towards a particle-assisted radiotherapy using lower radiation doses.
Composition of the Essential Oils of Ginseng Roots of Panax quinquefolium L. and Panax ginseng C.A. Meyer

Abstract The essential oils composition of the air-dried ginseng roots Panax quinquefolium L. cultivated in Poland and Panax ginseng C.A. Meyer cultivated in the North of China in Jiling were isolated by hydrodistillation and analyzed by capillary GC and GC-MS. The 60.91% of compounds in American roots Panax quinquefolium L. and 74.12% in Chinese roots Panax ginseng C.A. Meyer were identified. Differences in composition of obtained volatile oils were occurred. The main identified constituents of the oil from Panax quinquefolium L. were 2-epi-(E)-β-caryophyllene (20.78%), falcarinol (16.5%) and in Panax ginseng C.A. Meyer were spathulenol (11.55%), 2-epi-(E)-β-caryophyllene (10.88%).
The classification and identification of complex chemical compositions in yanhusuo herb using UPLC-Q-TOF/MS

The yanhusuo herb used in our study is derived from the yanhusuo's dried tubers, which belong to the Poppy Corydalis genus, and it is one of the traditional Chinese medicines (TCM) for relieving pain and promoting the circulation of blood and qi. The main components of yanhusuo include tetrahydroprotoberberine alkaloids, protoberberine alkaloids, protopine alkaloids and aporphine alkaloids. In this study, we aimed to realise the classification and identification of the alkaloid components in the yanhusuo herb by characteristic fragments and neutral losses using UPLC-Q-TOF/MS technology. After extensive review of the literature and some reference experiments, we found the fragmentation pattern of several alkaloids and the information of their corresponding fragment ions. Then, we determined the type of compound according to the type of fragment ions and the fragmentation pattern; thus we identified the compounds. Finally, we obtained 19 kinds of alkaloid compositions, including 12 kinds of tetrahydroprotoberberine alkaloids, 4 kinds of protoberberine alkaloids, 2 kinds of protopine alkaloids and 1 kind of aporphine alkaloid. In addition, analysis of the composition of yanhusuo was performed, which effectively solved the technical difficulties in the fingerprint analysis of TCM. This accurate and reliable method can provide a foundation for controlling the quality of different batches of the original ingredients.
Efficient Out-of-Core and Out-of-Place Rectangular Matrix Transposition and Rotation

Modern computers keep following the traditional model of addressing memory linearly for their main memory and out-of-core storage. While this model allows efficient row access to row-major 2D matrices, it introduces complexity to perform efficient column access. A common strategy to improve these accesses is to transpose or rotate the matrix beforehand, thus the accessing complexity is centralized in one transformation operation. Further column accesses are performed as row accesses to the transposed matrix therefore they are optimized to the memory model. In this article, we propose an efficient solution to perform in-memory or out-of-core rectangular matrix transposition and rotation by using an out-of-place strategy, reading a matrix from an input file and writing the transformed matrix to another (output) file. An originality of our processing algorithm is to rely on an optimized use of the page cache mechanism. It is parallel, optimized by several levels of tiling and independent of any disk block size. We evaluate our approach on five common storage configurations: HDD, hybrid HDD-SSD, SSD, software RAID 0 of several SSDs, and NVMe. We show that it brings significant performance improvement over a hand-tuned optimized reference implementation developed by the Caldera company and we confront it against the baseline speed of a straight file copy.
Preparation and characterization of L-glutamic acid-functionalized graphene oxide for adsorption of Pb(II)

ABSTRACT An efficient adsorbent (L-Glu/GO) was successfully synthesized by the reaction between L-glutamic acid (L-Glu) and graphene oxide (GO). The structure and morphology of this adsorbent were characterized by FTIR, SEM, XRD, and TGA. The SEM result indicated that the adsorbent was a nanomaterial with a size of about 50–400 nm. The adsorption experiments of various heavy ions on L-Glu/GO demonstrated that the adsorption performance of Pb(II) was better than others. Various variables affecting the adsorption of L-Glu/GO for Pb(II) were systematically explored. The experimental results indicated that the maximum adsorption capacity and equilibrium time of Pb(II) on L-Glu/GO were 513.4 mg g−1 and 40 minute, respectively. The sorption kinetics and isotherm fitted well with the pseudo-second-order model and Langmuir model, respectively. The sorption mainly was a chemical process. Thermodynamic studies revealed that the adsorption was a spontaneous and exothermic process. The adsorbent could be regenerated with HCl solution. Hence, it was suggested that the L-Glu/GO could be applied in the removal of Pb(II) from wastewaters. GRAPHICAL ABSTRACT