Miracle-dz/UniFAR-FTUs huggingface dataset:
Mutations in the long QT gene, KCNQ1, are an uncommon cause of atrial fibrillation

Atrial fibrillation (AF) is the most common clinical arrhythmia and a major source of morbidity and mortality.1 The underlying mechanisms for AF are highly heterogeneous and often related to associated structural heart disease.2 However, in several large studies 10–30% of subjects have no obvious heart disease, and are labelled as primary or lone AF.1 The identification of extended families with lone AF, and the mapping of discrete genetic loci in such families, raises the possibility that the heritable predisposition to this form of the arrhythmia is accessible.3,4 Recently, the first gene for an inherited form of AF was identified in a family with autosomal dominant transmission.5 A mutation was found in the first transmembrane spanning domain of the potassium channel gene, KCNQ1, resulting in serine-glycine substitution (S140G). Mutations in other residues throughout this gene cause long QT syndrome type 1 (LQT1). Co-expression of the S140G mutant allele with KCNE1 in cells results in a gain of function with increased current density, and an alteration of channel activation and inactivation. These observations contrast with the reduction in current density seen with LQT1 associated mutations. The unique phenotype associated with this activating mutation includes persistent AF and, surprisingly, QT prolongation. This …
DEMAND ANALYSIS, CONSUMER BEHAVIOUR AND TELECOMMUNICATIONS POLICY

Abstract. Regulation of the telecommunications sector has focused mainly on the supply side of the market e.g., market entry and licensing, access, interconnection, control over retail and/or wholesale pricing. This emphasis on the supply side was appropriate since the task was to install effectively competing alternative suppliers in former monopoly telecommunications markets. As competition has developed and the number of new entrants in fixed and mobile telecommunications markets has grown, there has been increased attention by some telecommunications regulators on the consumer demand side e.g., ‘number portability’ aimed at facilitating consumer ‘switching’. Such attention to the consumer demand-side is timely because informed consumers who are able and prepared to exert an ability to choose between competing suppliers are necessary to stimulate firms to innovate, improve quality and compete in terms of price. In making well-informed choices between suppliers, consumers not only benefit from competition, but they initiate and sustain it. Conversely, where
The Green Marketing Manifesto

Foreword. Acknowledgements. Introduction. Section I BACKGROUND. Setting the Scene. A Tipping Point - And Then What? The Green Consumer Bandwagon of 1989. The Green Challenges. The Marketing Challenge. The Green Consumer? (Or All Consumers? ). Sustainability - The Backroom Revolution. The Green Marketing Challenge. Green Marketing's Five I's. Endnote: Another Revolution. Section II THE GREEN MARKETING GRID. Overview. A. Green - Setting New Standards for Responsible Products, Services, Brands, Companies. B. Greener - Sharing Responsibility with Customers. C. Greenest - Shaping a New Culture of Responsibility Through Innovation. 1. Public - Company Story, Engagement Campaigns, Futures. 2. Social - Identity and Community. 3. Personal - Products and Habits. A1: Set an Example. A2: Credible Partners. A3: Market a Benefit. B1: Develop the Market. B2: Tribal Brands. B3: Change Usage. C1: New Business Concepts. C2: Trojan Horse Ideas. C3: Challenging Consuming. A: Setting New Standards (Green). A1: Set an Example. A2: Credible Partners . A3: Market a Benefit. B: Sharing Responsibility (Greener). B1: Develop the Market. B2: Social/Tribal Brands. B3: Change Usage. C: Supporting Innovation (Greenest). C1: New Business Concepts. C2: Trojan Horse Ideas. C3: Challenging Consuming . Section III CONCLUDING THOUGHTS. Ideas Good, Image Bad. A Fresh Start for Green Marketing. References. Index.
Evaluating a hepatitis c quality gap: missed opportunities for HCV-related cares.

OBJECTIVES Diagnosis of chronic hepatitis C virus (HCV) is a 2-step process involving hepatitis C antibody (HCVab) testing followed by viral ribonucleic acid (RNA) testing. The HCV status of those with a positive HCVab without viral testing cannot be determined. This study sought to describe the HCV-related care provided to patients in this care gap. STUDY DESIGN Retrospective cohort study of active patients with a positive HCVab test who did not complete viral testing. METHODS Electronic medical records (EMRs) were reviewed to determine if each subject's first positive HCVab result was acknowledged by a provider. For results acknowledged, we described provider actions in response to the result. When providers performed specific clinical actions within 1 year of the positive HCVab test, we captured the type of action taken. When the unsubstantiated diagnosis was documented in the EMR, we determined if the diagnosis was mentioned by subsequent providers. RESULTS Positive HCVab results were not acknowledged in 31% of subjects. In 35%, providers added chronic HCV to the problem list in the EMR, resulting in a higher likelihood of subsequent providers mentioning the diagnosis in their EMR documentation. In 143 subjects whose providers recommended HCV-related clinical actions within 1 year of the positive result, 45% were educated about HCV and 42% had their liver enzymes monitored. CONCLUSIONS With more widespread testing anticipated and more effective treatments available, health systems should ensure the HCV diagnostic process results in the delivery of an accurate and timely HCV diagnosis, to reduce the risk of harm to patients.
The role of banks in the transmission of monetary policy

The transmission of monetary policy, especially in light of recent events, has received increased attention, especially with respect to the efficacy of the bank lending channel. This paper summarizes the issues associated with isolating the bank lending channel and determining the extent to which it is operational. Evidence on the effectiveness of the bank lending channel is presented, both in the United States and abroad. The paper then provides observations about the likely consequences for the effectiveness of the lending channel of the changes in the financial environment associated with the recent financial crisis.
Sentiments analysis for prediction the governor of east java 2018 in twitter

The East Java Governor Election which will be held in 2018 is also felt in the virtual world especially Twitter social media. All people freely argue about their respective governor candidates, the memorandum raises many opinions, not only positive or neutral but also negative opinions. Media growth is so rapid, revealing a lot of online media from the news media to social media. Social media alone is Facebook, Twitter, Path, Instagram, Google+, Tumblr, Linkedin and many more. Today's social media is not only used as a means of friendship or making friends, but also for other activities. Promos of trading or buying and selling, until political party promos or campaigns of candidates for regents, governors, legislative candidates until presidential candidates. The research objective is to conduct a method of analyzing the sentiments of 2018 East Java Governor candidates on Twitter social media with optimal and maximum optimization. While the benefits are to help the community conduct research on opinions on twitter which contains positive, neutral or negative sentiments. Analysis of the sentiments of East Java Governor candidates in 2018 on twitter social media using non-conventional processes that save costs, time and effort. The results of Khofifah's dataset are 77% accuracy, 79.2% precision value, 77% recall value, 98.6% TP rate and 22.2% TN rate. For the results of Gus dataset, the accuracy is 76%, the precision value is 74.4%, the recall value is 76%, the TP rate is 93.8% and the TN rate is 52.9%.
Morphological analyses of the human tongue musculature for three-dimensional modeling.

Skilled movements of the tongue in speech articulation reflect complex formation of the tongue musculature, although its description in the anatomical literature is rather limited for developing a realistic computational model of the tongue. This study presents detailed descriptions of the muscular structure of the human tongue based on macroscopic and microscopic observations and provides three-dimensional schemata of the tongue musculature. Histologic examination revealed that the tongue consists of five strata, stacked along the courses of the fibers of the genioglossus muscle in proximal-distal directions. This stratum structure exists in the entire tongue tissue, indicating that the lingual musculature can be divided into the inner and outer regions. The former consisted of the "stem" and "core," and the latter of the "cover" and "fringe. " In gross dissection, the tongue was cut into wedge-like blocks along the course of the genioglossus muscle to examine muscle fiber arrangement. Using this approach, it was determined that serial repetitions of "structural units" composed the inner musculature of the tongue. Each unit consisted of a pair of thin muscle fiber laminae; one was composed of the genioglossus and vertical muscles, and the other of the transverse muscle. In the apex, the laminae lacked the fibers of the genioglossus. These findings have been incorporated in three-dimensional schemata of the tongue musculature.
Uso de informação estrutural para melhorar qualidade de busca em coleções web

Ao contrario dos documentos de textos planos, as paginas Web sao comumente com- postas de diferentes segmentos ou blocos tais como barras de navegacao, formularios de interacao, secoes principais, anuncios de privacidade e copyright. Este e um fato de interesse, visto que trabalhos anteriores demonstraram que esses diferentes segmen- tos, que podem ser identificados automaticamente nas paginas Web, podem ser usados para melhorar atividades de recuperacao de informacao tais como busca, analise de Web links, e mineracao de dados na Web. Por exemplo, informacao sobre os blocos das paginas pode ser usada para estimar pesos de termos de acordo com a ocorrencia desses termos dentro dos blocos (ao inves de dentro das paginas). Como consequencia, a importância da ocorrencia de um termo em uma pagina Web pode variar dependendo de sua localizacao (ou bloco) dentro das paginasWeb. Por exemplo, a ocorrencia de um termo no conteudo principal de uma pagina pode ser mais importante para tarefas de ordenacao de documentos que a ocorrencia deste mesmo termo no menu desta pagina.Nesta tese, sao investigados diferentes meios de como melhorar processos de busca por informacao em colecoes de paginas Web atraves do uso da estrutura das paginas. Para tanto, nos propomos: (i) um novo modelo de representacao do conteudo de Web sites em sistema de recuperacao de informacao que leva em consideracao a estrutura interna das paginas; (ii) um metodo de identificacao automatica da estrutura interna das paginas Web, de acordo com o modelo de representacao do conteudo de Web sites proposto neste trabalho; e (iii) um conjunto de nove funcoes capazes de distinguir o impacto de ocorrencias de termos dentro dos blocos das paginas, on inves de dentro das paginas completas. Estas funcoes, que sao usadas para compilar uma versao modificada do modelo BM25, possuem a vantagem de nao requerer processos de aprendizagem nem qualquer outro tipo de intervencao manual para computar as ordenacoes de respostas para as consultas, tal como requerido por trabalhos anteriores.Usando quatro colecoes de paginas Web, foram executados experimentos para comparar nossos metodos baseados em blocos com (i) dois modelos de recuperacao de informacao baseados em blocos propostos na literatura, e com (ii) um metodo tradicional de ranking que nao usa informacao de blocos. Os resultados indicam que nossos metodos baseados em blocos sao capazes de obter ganhos de qualidade de resposta em relacao a todos os baselines, gerando ganhos medios de precisao de 5% a 20%. Alem de melhorar a efetividade da tarefa de busca, nossos metodos baseados em blocos reduzem o tamanho do indice usado nos processos de busca em ate 27.9% quando comparado com os baselines, diminuindo os requisitos de armazenagem do sistema e o custo de processamento das consultas.
Transcriptional profiling of bovine muscle-derived satellite cells during differentiation in vitro by high throughput RNA sequencing

Abstract In this study, we utilized high throughput RNA sequencing to obtain a comprehensive gene expression profile of muscle-derived satellite cells (MDSCs) upon induction of differentiation. MDSCs were cultured in vitro and RNA was extracted for sequencing prior to differentiation (MDSC-P), and again during the early and late differentiation (MDSC-D1, and MDSC-D3, respectively) stages. Sequence tags were assembled and analyzed by digital gene expression profile to screen for differentially expressed genes, Gene Ontology annotation, and pathway enrichment analysis. Quantitative real-time PCR was used to confirm the results of RNA sequencing. Our results indicate that certain of genes were changed during skeletal muscle cell development, cell cycle progression, and cell metabolism during differentiation of bovine MDSCs. Furthermore, we identified certain genes that could be used as novel candidates for future research of muscle development. Additionally, the sequencing results indicated that lipid metabolism might be the predominant cellular process that occurs during MDSC differentiation.
Effect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in rat.

AIM Retention and accumulation of toxic hydrophobic bile salts within hepatocyte may cause hepatocyte toxicity by inducing apoptosis. Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Z-Val-Ala-Asp (OMe)-fluoromethyl ketone (ZVAD-fmk) is a cell-permeable irreversible inhibitor of caspase. The purpose of this study was to evaluate the possible effect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in the rat. METHODS Male Sprague-Dawley rats, weighing 250-300 g, were randomized to five groups of five rats each. Group 1 underwent common bile duct ligation and simultaneous treatment with ZVAD-fmk (dissolved in dimethylsulfoxide (DMSO)). Group 2 underwent common bile duct ligation and simultaneous treatment with Z-Phe-Ala-fluoromethyl ketone ( ZFA-fmk, dissolved in DMSO). Group 3 underwent sham operation and simultaneous treatment with the same amount of DMSO. Group 4 underwent sham operation and simultaneous treatment with the same amount of normal saline. Group 5 underwent common bile duct ligation without other manipulation. After three days, liver tissue was harv-ested for histopathologic analysis and measurements of apoptosis. RESULTS When compared with sham operation, common bile duct ligation significantly increased hepatocyte apoptosis (P = 0.008) and ductular proliferation (P = 0.007). ZVAD-fmk significantly diminished the increased hepatocyte apoptosis and ductular proliferation after common bile duct ligation (P = 0.008 and P = 0.007, respectively). ZFA did not show the same effects. CONCLUSION Hepatocyte apoptosis and ductular proliferation significantly increased after common bile duct ligation. ZVAD-fmk effectively diminished the increased hepatocyte apoptosis and ductular proliferation after common bile duct ligation, whereas ZFA-fmk did not.
Axis I Psychopathology in Individuals with Traumatic Brain Injury

Objectives:To assess the incidence, comorbiclity, and patterns of resolution of DSM-IV mood, anxiety, and substance use disorders in individuals with traumatic brain injury (TIM) Design:The Structured Clinical Interview for DSM-IV Diagnoses (SC1D) was utilized. Diagnoses were determined for three onset points relative to TBI onset: prc-TBI, post-TUI, and current diagnosis. Contrasts of prevalence rates with communitybased samples, as well as chi-square analysis and analysis of variance were used. Demographics considered in analyses included gender, marital status, severity of injury, and years since TIM onset Setting:Urban, suburban, and rural New York state. Participants: 100 adults with TBI who were between the ages of 18 and 65 years and who were, on average, 8 years post onset at time of interview Main Outcome Measures:SCID Axis I mood diagnoses of major depression, dysthymia, and bipolar disorder; anxiety diagnoses of panic disorder, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), and phobia; and substance use disorders Results:Prior to TBI, a significant percentage of individuals presented with substance use disorders. After TBI, the most frequent Axis I diagnoses were major depression and select anxiety disorders (ie, PTSD, OCD, and panic disorder). Comorbidity was high, with 44% of individuals presenting with two or more Axis 1 diagnoses post TBI. Individuals without a pre-TBI Axis I disorder were more likely to develop post-TBI major depression and substance use disorders. Rates of resolution were similar for individuals regardless of previous psychiatric histories. Major depression and substance use disorders were more likely than were anxiety disorders to remit Conclusion:TBI is a risk factor for subsequent psychiatric disabilities. The need for proactive psychiatric assessment and timely interventions in individuals post TBI is indicated
Do I want to protect myself or support others

Dit onderzoek richt zich op de relatie tussen solidair gedrag en reorganisaties. Het doel is inzicht te bieden in het begrijpen en verklaren van solidair gedrag op de werkvloer in tijden van reorganisaties. De centrale vraagstelling luidt: Wat is de invloed van reorganisaties op solidair gedrag op de werkvloer, en (hoe) kan dit verklaard worden door de balans tussen solidair gedrag van en solidair gedrag naar organisatieleden?
The Audit Committee: A Gatekeeper for Effective Corporate Governance

In recent years, much attention has focused on the role of the corporate audit committee within corporate governance in the wake of several high profiles corporate financial debacles, such as Maxwell, Polly Peck and BCCI Bank in the UK, Enron and WorldCom in the US, and Parmalat in Italy. The value of strong corporate governance has assumed a critical role in organisations since these highly publicised corporate scandals. Regulations have been introduced in most countries around the world to enhance the functioning of audit committees as a device for strengthening good corporate governance to avoid future accounting fiascos. This paper posits that arguably only an audit committee that is independent (e.g., comprised solely of outside directors), active (e.g., meeting frequently) and with members possessing financial expertise can contribute to effective corporate governance.
Working for the Enemy? The Impact of Investment Bankers on Deal Flow

This paper examines the impact of investment banker job changes on the M&A and equity market shares of investment banks. Using a unique sample of job changes between 1998 and 2004, we find, on average, that the bank losing the banker experiences a negative and significant decrease in its industry market share while the gaining bank's market share doesn't change significantly. However, after controlling for deal and bank-level characteristics, hiring a banker from an investment bank with a more prominent industry presence has a positive impact on both equity and M&A market share for the gaining bank and a negative impact on the losing bank's M&A market share. After the banker switches firms, we find a significant amount of business follows the banker from the losing bank to the gaining bank. Pooled and paired wealth effects around the announcement of a switch for gaining and losing banks are positive and significant, suggesting the market views banker additions as value increasing. Overall, our results suggest human capital is a critical component of investment banking deal flow.
Amifostine—Antioxidant Drug in Anticancer Therapy

Antineoplastic drugs and/or their metabolites are very reactive chemically and easily react with cell components, both those neoplastic and healthy, which leads to uncontrolled cell damage. Research is being carried out to discover new drugs preventing those destructive changes in healthy cells. Amifostine is one of the few drugs with protective abilities in regard to healthy tissues during antineoplastic therapy. Amifostine alone is inactive chemically, but active metabolite amifostine WR-1065 has been assumed to protect the healthy tissues during antineoplastic therapy by bounding of anticancer drug, causing their detoxification and/or eliminating the free radicals generated during radiation and cytostatic therapy. WR-1065 also protects the healthy tissues by inhibition of apoptosis caused by irradiation and/or alkylating compounds. However, the protective mechanism of amifostine influence on healthy cells has not been fully comprehended, and the research is still being carried out.
Housing Partnerships: A New Approach to a Market at a Crossroads

Although the United States has developed highly sophisticated markets for funding corporate investment projects, markets for financing home ownership are comparatively rudimentary. When a corporation wishes to fund a project, it can choose any mix of debt and equity financing. In contrast, to buy a home, a household must take on debt in the form of a mortgage. The authors of this book propose the development of new markets, called Partnership Markets, that would allow households to use equity finance to buy their homes. With these new markets, a household would be able to finance housing not only with a mortgage, but also with an institutional investor who would provide part of the equity capital for the house in exchange for a share of the ultimate selling price. The new markets would offer many benefits to both homeowners and the broader financial community. In the current market, many Americans are forced to rent housing because they cannot afford to buy. Those who do buy are burdened with high debt payments. They also have the vast majority of their wealth tied up in their home and are exposed to the high risk levels of such an undiversified portfolio. With Partnership Markets, households would be able to buy homes with much smaller mortgages, thereby greatly reducing their expenses. They would also be able to diversify their assets and create less risky portfolios. For the broader financial community, Partnership Markets would provide an opportunity to diversify into the residential real estate market. To give the reader a rounded view of their proposal, the authors explain the economic theory of the housing market and the housing finance market, as well as key aspects of the institutional structure and performance records of the current market. They discuss the wider ramifications of their proposal, including changes in the form and structure of the secondary market, the government's role in the housing market, the composition of assets held by institutions, and the general level of risk for individuals.
Routine Identification of Medical Fungi by the New Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight System with a New Time-Effective Strategy

ABSTRACT We report here a clinical evaluation of the Vitek MS system for rapid fungal identification. A strategy that uses a single deposit without prior protein extraction was utilized to save time and money. Clinical isolates from the Toulouse University hospital were used to evaluate the performance of the Vitek MS compared to that of both routine laboratory techniques and Vitek2. The Vitek MS performed well in the identification of yeasts and Aspergillus fungi (93.2% of correct identifications).