Miracle-dz/UniFAR-FTUs huggingface dataset:
Dificultades específicas del aprendizaje de las matemáticas en los primeros años de la escolaridad: detección precoz y características evolutivas

Esta tesis ha intentado establecer un puente entre la investigacion y el ambito profesional, en concreto entre la investigacion sobre el aprendizaje de las matematicas y la orientacion psicopedagogica. Hemos estudiado las Dificultades Especificas de Aprendizaje en Matematicas (DAM) desde una perspectiva curricular en los primeros anos de la escolaridad, asi como su evolucion. Con este fin hemos desarrollado una prueba de evaluacion que pretende servir de instrumento de deteccion de los ninos de riesgo, y que a la vez pueda constituir en el futuro una guia para la intervencion. La tesis esta estructurada en dos partes, la copilacion teorica junto a la justificacion de la prueba elaborada para este trabajo, ocupan la primera parte y la investigacion empirica ocupa la segunda. Como marco teorico y experimental nos hemos apoyado en el conocimiento sobre el desarrollo matematico de los ninos sin dificultades y en las investigaciones sobre los ninos con DAM. En el estudio empirico hemos valorado a lo largo del ciclo a dos grupos de alumnos con DAM, uno desde 1o hasta 3o y otros desde 3o hasta 5o y los hemos comparado con dos grupos de ninos seleccionados al azar de las mismas cohortes. Las conclusiones e implicaciones educativas mas destacadas las probariamos resumir de la siguiente forma: 1,- Los profesores son capaces de detectar a los alumnos que van a presentar DAM con un nivel de aciertos elevado, por lo que es necesario tener en cuenta su opinion en la evaluacion psicopedagogica. 2,- Para la prediccion de la competencia matematica a finales de ciclo es suficiente conocer la ejecucion del alumno en esta area a inicios de ciclo. El 90% de los ninos cuya competencia en matematicas este por debajo de 1,5 desviaciones tipicas de la media de los ninos sin dificultades, seguira presentando este retraso o mas al final del ciclo. Aunque con el paso de los anos los mas probables es que su retraso vaya
Seizure detection in neonates: Improved classification through supervised adaptation

The goal of neonatal seizure detection is the development of a patient independent system to alert staff in the neonatal intensive care unit of ongoing seizures. This study demonstrates the potential in adapting a patient independent classifier using patient specific data. Supervised adaptation is investigated using the basic gradient descent algorithm and least mean squares procedures. An increase in mean ROC area of 3% is obtained for the best performing learning algorithm, yielding an increase in mean accuracy of 7.7% compared to the patient independent algorithm.
Multi-Pattern $n$-Detection Stuck-At Test Sets for Delay Defect Coverage

An n-detection test set detects each target fault n times. A higher value of n increases the likelihood that defects around the site of a target fault will be detected. However, an n -detection test set that consists of single-pattern tests (generated for single stuck-at faults) cannot guarantee that delay defects will be detected. For this it is necessary to use multi-pattern tests. The procedure described in this work generates a multi-pattern n-detection test set for single stuck-at faults. The procedure is applied starting from a single-pattern n-detection test set for single stuck-at faults. Experimental results demonstrate that the multi-pattern n-detection test set achieves a high transition fault coverage. It achieves a similar bridging fault coverage to the single-pattern test set. An added advantage is that the multi-pattern test set typically requires significantly fewer clock cycles for test application than the single-pattern test set.
Upregulation of interleukin‐1 by Epstein–Barr virus latent membrane protein 1 and its possible role in nasopharyngeal carcinoma cell growth

Nasopharyngeal carcinoma (NPC) is associated with Epstein–Barr virus (EBV) infection. We previously found that interleukin (IL)‐1α and IL‐1β significantly increased in NPC tissues. This study investigated what EBV‐encoded proteins were involved in such IL‐1 production.
Measuring Walking: A Handbook of Clinical Gait Analysis

co uk customer reviews measuring walking a. measuring walking a handbook of clinical gait analysis. 9781908316660 measuring walking a handbook of clinical. pdf gait analysis in children with cerebral palsy. customer reviews measuring walking a. 1832development of gait pdf . measuring walking a handbook of clinical gait analysis by. measuring walking a handbook of clinical gait analysis. measuring walking a handbook of clinical gait analysis. blog walking with richard. gait assessment technology physical function assessment. measuring walking by richard baker overdrive rakuten. gait and clinical gait analysis sciencedirect. book walking with richard. measuring walking a handbook of clinical gait analysis. measuring walking a handbook of clinical gait analysis. gait amp posture vol 39 issue 4 pages 1005 1162 april. book review measuring walking a handbook of clinical. value of gait analysis for measuring disease severity. affordable gait analysis using augmented reality markers. clinical gait analysis for assessing bilateral lower. measuring walking a handbook of clinical gait analysis. measuring walking richard w baker hftad. gaitlab ir. measuring walking a handbook of clinical gait analysis. clinical gait analysis how is clinical gait analysis. richard w baker measuring walking a handbook of. measuring walking a handbook of clinical gait analysis. measuring walking mac keith press. effect of walking in footwear with varying heel sole. advanced methods for gait analysis data processing. measuring walking mac keith press. book review measuring walking a handbook of clinical. measuring walking a handbook of clinical gait analysis. measuring walking a handbook of clinical gait analysis. clinical assessment of gait musculoskeletal key. measuring walking a handbook of clinical gait analysis. measuring walking a handbook of clinical gait analysis. book review measuring walking a handbook of clinical. wiley measuring walking a handbook of clinical gait. parison of gait with and without ankle foot orthoses. measuring walking a handbook of clinical gait analysis. clinical gait analysis stanford university. measuring walking a handbook of clinical gait analysis. introduction to movement analysis cmas. journal of biomechanics. effects of walking speed on gait biomechanics in healthy. measuring walking af richard baker som e bog bogreolen dk. book review measuring walking a handbook of clinical
Syringolin A, a new plant elicitor from the phytopathogenic bacterium Pseudomonas syringae pv. syringae, inhibits the proliferation of neuroblastoma and ovarian cancer cells and induces apoptosis

Abstract. Syringolin A is a new plant elicitor produced by the plant pathogen Pseudomonas syringae pv. syringae. The goal of this study was to investigate whether syringolin A exhibits anti‐proliferative properties in cancer cells. The treatment of human neuroblastoma (NB) cells (SK‐N‐SH and LAN‐1) and human ovarian cancer cells (SKOV3) with syringolin A (0–100 µm) inhibited cell proliferation in a dose‐dependent manner. The IC50 (50% inhibition) for each cell line ranged between 20 µm and 25 µm. In SK‐N‐SH cells, the treatment with 20 µm syringolin A led to a rapid (24 h) increase of the apoptosis‐associated tumour suppressor protein p53. In addition, we found that the treatment of SK‐N‐SH cells caused severe morphological changes after 48 h such as rounding of cells and loss of adherence, both conditions observed during apoptosis. The induction of apoptosis by syringolin A was confirmed by both poly (ADP‐ribose) polymerase (PARP) cleavage and annexin V assay. Taken together, we show for the first time that the natural product syringolin A exhibits anti‐proliferative activity and induces apoptosis. Syringolin A and structurally modified syringolin A derivatives may serve as new lead compounds for the development of novel anticancer drugs.
Pulmonary involvement in patients with early rheumatoid arthritis

Objectives: To assess the pleuropulmonary changes in patients with early rheumatoid arthritis (RA), using high‐resolution computed tomography (HRCT). Methods: Forty‐three non‐smoking patients with early RA were included. The disease duration was<1 year, without previous treatment. Disease activity was assessed using the 28‐joint indices score (DAS28). Hand and wrist X‐rays were evaluated using Larsen's criteria. Pulmonary functional tests (PFTs) were performed in 32 patients. The patients and 18 non‐smokers healthy individuals were assessed by plain chest X‐ray (CXR) and HRCT of the lungs. Results: HRCT revealed air trapping in 69% (25/36), bronchiectasis in 58% (25/43), bronchial wall thickening in 52% (22/43) and ground glass opacities (GGOs) in 35% (15/43) of the patients. Pleural thickening and effusion were observed in 11% (5/43). CXR was abnormal in one patient revealing a single pulmonary nodule. GGOs were the only HRCT sign observed exclusively in RA patients. All the other abnormalities were depicted in the control group at the same frequency as in the patients. However, the extent (as expressed by the HRCT score) of air trapping, bronchiectasis and bronchial wall thickening was significantly greater in the patients than in the control group (p<0.05). The PFTs were within normal values. DAS28, PFTs, and the Larsen score did not show any significant correlation with either each HRCT sign score separately or the total score. Conclusions: Lung abnormalities are frequently observed in patients with early RA on HRCT, even when CXR and PFTs are normal. Limited areas of GGOs were the abnormalities depicted exclusively in patients.
Design and realization of a L-band 1200W power amplifier

The Design guidelines are presented for circuit matching and power combination in a high-power amplifier. And then a practical L-band solid-state amplifier is designed and realized with high output power (up to 1200W continuous wave), high linearity, low gain variation and high stability to meet the increasing needs for applications in satellite communication and navigation, TT&C (Telemetry Tracking and Command), satellite television broadcasting, etc.
Interpolation Using Hankel Tensor Completion

Summary We present a novel multidimensional seismic trace interpolator that works on constant frequency slices. It performs completion on Hankel tensors whose order is twice the number of spatial dimensions. Completion (estimating the unknown values within the tensor) is done by reducing the rank using an Alternating Least Squares algorithm. The new interpolator can better handle large gaps and high sparsity than existing completion methods.
The arithmetic of receiver scheduling for electronic support

In Electronic Support, it is well known that periodic search strategies for swept-frequency superheterodyne receivers (SHRs) can cause synchronisation with the radar it seeks to detect. Synchronisation occurs when the periods governing the search strategies of the SHR and radar are commensurate. The result may be that the radar is never detected. This paper considers the synchronisation problem in depth. We find that there are usually a finite number of synchronisation ratios between the radar’s scan period and the SHR’s sweep period. We develop three geometric constructions by which these ratios can be found and we relate them to the Farey series. The ratios may be used to determine the intercept time for any combination of scan and sweep period. This theory can assist the operator of an SHR in selecting a sweep period that minimises the intercept time against a number of radars in a threat emitter list.
Traditional Chinese medicine for pressure ulcer: a meta‐analysis

To assess the effect of Traditional Chinese Medicine (TCM) [Chinese herbal medicine ointment (CHMO), acupuncture and moxibustion] on pressure ulcer. In this study, we searched MEDLINE, EMBASE, CENTER, CBM, CNKI, WAN FANG and VIP for articles published from database inception up to 4 April 2011. We included randomised controlled trials (RCTs), which compared the effects of TCM with other interventions. We assessed the methodological quality of these trials using Cochrane risk of bias criteria. Ten of 565 potentially relevant trails that enrolled a total of 893 patients met our inclusion criteria. All the included RCTs only used CHMO intervention, because acupuncture and moxibustion trials failed to meet the inclusive criteria. A meta‐analysis showed beneficial effects of CHMO for pressure ulcer compared with other treatments on the total effective rate [risk ratio (RR): 1·28; 95% confidence interval (CI): 1·20–1·36; P = 0·53; I2 = 0%), curative ratio (RR: 2·02; 95% CI: 1·73–2·35; P = 0·11; I2 = 37%) and inefficiency rate (RR: 0·16; 95% CI: 0·02–0·80; P = 0·84; I2 = 0%). However, the funnel plot indicated that there was publication bias in this study. The evidence that CHMO is effective for pressure ulcer is encouraging, but due to several caveats, not conclusive. Therefore, more rigorous studies seem warranted.
Molecular Mechanism of the Constitutive Activation of the L250Q Human Melanocortin‐4 Receptor Polymorphism ‡

The Melanocortin‐4 Receptor is a G‐protein coupled receptor that has been physiologically linked to participate in the regulation of energy homeostasis. The Melanocortin‐4 Receptor is stimulated by endogenous melanocortin agonists derived from the pro‐opiomelanocortin gene transcript and antagonized by the endogenous antagonist agouti‐related protein. Central administration of melanocortin agonists has been demonstrated to decrease food intake and conversely, treatment with antagonists resulted in increased food intake. Deletion of the Melanocortin‐4 Receptor gene from the mouse genome results in an obese and hyperphagic phenotype. Polymorphisms of the human Melanocortin‐4‐Receptor have been found in severely obese individuals, suggesting that Melanocortin‐4 Receptor malfunction might be involved in human obesity and obesity‐associated diabetes. Herein, we have performed experiments to understand the molecular mechanisms associated with the L250Q human Melanocortin‐4‐Receptor polymorphism discovered in an extremely obese woman. This L250Q human Melanocortin‐4‐Receptor has been pharmacologically characterized to result in a constitutively active receptor. The fact that a constitutively active human Melanocortin‐4‐Receptor mutation was found in an obese person is a physiologic contradiction, as chronic activation of the human Melanocortin‐4‐Receptor and subsequently high cyclic adenosine monophosphate levels should theoretically result in a normal or lean phenotype. In this study, we demonstrated that agouti‐related protein acts as an inverse agonist at this constitutively active receptor, and we propose a mechanism by which agouti‐related protein might contribute to the obese phenotype in the L250Q patient. In addition, using receptor mutagenesis, pharmacology, and computer modeling approaches, we investigated the molecular mechanism by which modification of the L250 residue results in constitutive activation of the human Melanocortin‐4‐Receptor.
A Super-Peer based Method to Discover QoS Enhanced Alternate Paths

In the next generation Internet, the network should not only be considered as a communication medium, but also as an endless source of services available to the end-systems. These services (i.e. overlay applications) would be composed of multiple cooperative distributed software elements that dynamically build an ad hoc communication mesh (i.e. an overlay association). In a previous contribution, we proposed a collaborative distributed method to provide enhanced QoS between end-points within an overlay association. It aimed at discovering and utilizing composite alternate end-to-end paths that experience better QoS than the path given by the default IP routing mechanisms. Extending this work, this paper presents our investigations on an unstructured super-peer network-based method to discover such QoS enhanced alternate path
Insertion/Deletion Polymorphisms in Tribal Populations of Southern India and Their Possible Evolutionary Implications

India has the unique distinction of having perhaps the largest diversities, both biological and cultural. The Nilgiri Hills of southern India, a home for several tribal pockets representing different genetic isolates, provides a genetic wealth to understand human evolution. We have analyzed eight widely distributed polymorphic insertion/deletion loci (AluAPO, AluACE, AluD1, AluPLAT, AluPV92, AluFXIIIB, CD4 del and mtNUC) in 250 unrelated individuals from five tribal populations (Badaga, Irula, Kota, Kurumba, and Toda). All loci were highly polymorphic except the CD4 del locus, at which the deletion allele was fixed in Kotas and Kurumbas. The levels of average heterozygosities were found to be high in all the populations. In most populations, they were also higher than those predicted by the island model of population structure. The gene diversity (GST = 8.3%) was found to be higher than that in populations of most global regions with the exception of Africa. It is clear from the present study that drift effects could have accentuated the process of genetic differentiation of the tribal populations. The possibility of an early demographic expansion of modern humans within south India also cannot be ruled out.
Simulating a diffusion on a graph. Application to reservoir engineering

We develop a simple Monte Carlo method to compute the position at a given time of a diffusion on a graph, with constant speed on each edge. This method is exact, and we claim it could be used for simulating the position of a particle in a fissured media. Besides, we advocate that the notion of diffusions on graphs could be useful to understand the behavior of one-dimensional diffusions whose infinitesimal generator has piecewise constant coefficients.
LIVER REGENERATION AND SURGICAL OUTCOME IN DONORS OF RIGHT‐LOBE LIVER GRAFTS

Introduction. Previous studies of healthy live‐liver donors have suggested that complete liver regeneration occurs within a matter of weeks; however, there have been no long‐term studies evaluating liver regeneration and few studies documenting long‐term donor outcome. Materials and Methods. Fifty‐one donors who provided right‐lobe grafts underwent volumetric spiral computed tomography scans preoperatively and postoperatively at time intervals of 1 week and 1, 3, 6, and 12 months. Patient demographics, surgical data, and postoperative outcome were correlated with liver regeneration data. Donor surgical outcome was followed prospectively and recorded in a comprehensive database. Results. Thirty‐three males and 18 females (mean age 36.0±9.6 years) provided 51 right‐lobe grafts. Mean follow‐up was 9.8±3.4 months. No donor operation was aborted, and surgical morbidity and mortality rates were 39% and 0%, respectively. Donor remnant liver volume was 49.4±5.7% of the original total liver volume (TLV). Overall liver regeneration was 83.3±9.0% of the TLV by 1 year. Female donors had significantly slower liver regrowth when compared with males at 12 months (79.8±9.3% vs. 85.6±8.2%, P<0.01). There was no effect of age, body mass index, operative time, estimated blood loss, postoperative complications, or perioperative liver function tests on liver regeneration. Discussion. Liver regeneration continues throughout the first postoperative year. Only one donor achieved complete liver regeneration during this time period; however, all donors have maintained normal liver function without long‐term complications. Longer follow‐up is needed to determine whether donors ever achieve original TLV.
The benefits of folic acid-modified gold nanoparticles in CT-based molecular imaging: radiation dose reduction and image contrast enhancement

Abstract X-ray computed tomography (CT) requires an optimal compromise between image quality and patient dose. While high image quality is an important requirement in CT, the radiation dose must be kept minimal to protect the patients from ionizing radiation-associated risks. The use of probes based on gold nanoparticles (AuNPs) along with active targeting ligands for specific recognition of cancer cells may be one of the balanced solutions. Herein, we report the effect of folic acid (FA)-modified AuNP as a targeted nanoprobe on the contrast enhancement of CT images as well as its potential for patient dose reduction. For this purpose, nasopharyngeal KB cancer cells overexpressing FA receptors were incubated with AuNPs with and without FA modification and imaged in a CT scanner with the following X-ray tube parameters: peak tube voltage of 130 KVp, and tube current–time products of 60, 90, 120, 160 and 250 mAs. Moreover, in order to estimate the radiation dose to which the patient was exposed during a head CT protocol, the CT dose index (CTDI) value was measured by an X-ray electrometer by changing the tube current–time product. Raising the tube current–time product from 60 to 250 mAs significantly increased the absorbed dose from 18 mGy to 75 mGy. This increase was not associated with a significant enhancement of the image quality of the KB cells. However, an obvious increase in image brightness and CT signal intensity (quantified by Hounsfield units [HU]) were observed in cells exposed to nanoparticles without any increase in the mAs product or radiation dose. Under the same Au concentration, KB cells exposed to FA-modified AuNPs had significantly higher HU and brighter CT images than those of the cells exposed to AuNPs without FA modification. In conclusion, FA-modified AuNP can be considered as a targeted CT nanoprobe with the potential for dose reduction by keeping the required mAs product as low as possible while enhancing image contrast.
Looking for some free energy? Call JEFREE (…)

In this communication, we present the Jarzynski's Equality FREe Energy (JEFREE) library, an efficient and easy‐to‐use C++ library targeted to the calculation of the free energy profile along a selected generalized coordinate of a system, within the framework of the nonequilibrium steered transformations as introduced by Jarzynski [Phys. Rev. E, 1997, 56, 5018]. JEFREE can be readily integrated into any code, since both C and FORTRAN wrappers have been developed, and easily customizable by a user thanks to the object‐oriented programming paradigm offered by the C++ language. Also, JEFREE implements the novel idea of making a total “morphing” of the system energy landscape before initiating the proper steering stage. This proves to be an efficient mean to overtake the problematic sampling of the initial equilibrium state when the number of degrees of freedom is high and the landscape owns many local minima separated by large energy barriers. The calculation of the free energy profile for the rotation along torsion angles in alkyl chains is presented as an example of application of our tool. © 2014 Wiley Periodicals, Inc.
Analyzing factors involved in the HPO-based semantic similarity calculation

Although disease diagnosis have greatly benefited from next generation sequencing technologies, it is still difficult to make the right diagnosis based on purely sequencing technologies for many diseases with complex phenotypes and high genetic heterogeneity. Recently, calculating Human Phenotype Ontology (HPO)-based phenotype semantic similarity has contributed a lot for completing disease diagnosis. However, factors which affect the accuracy of HPO-based semantic similarity have not been evaluated systematically. In this study, we propose a new framework called HPOFactor to evaluate these factors.