Miracle-dz/UniFAR-FTUs huggingface dataset:
Hybrid Deep Sequential Modeling for Social Text-Driven Stock Prediction

In addition to only considering stocks' price series, utilizing short and instant texts from social medias like Twitter has potential to yield better stock market prediction. While some previous approaches have explored this direction, their results are still far from satisfactory due to their reliance on performance of sentiment analysis and limited capabilities of learning direct relations between target stock trends and their daily social texts. To bridge this gap, we propose a novel Cross-modal attention based Hybrid Recurrent Neural Network (CH-RNN), which is inspired by the recent proposed DA-RNN model. Specifically, CH-RNN consists of two essential modules. One adopts DA-RNN to gain stock trend representations for different stocks. The other utilizes recurrent neural network to model daily aggregated social texts. These two modules interact seamlessly by the following two manners: 1) daily representations of target stock trends from the first module are leveraged to select trend-related social texts through a cross-modal attention mechanism, and 2) representations of text sequences and trend series are further integrated. The comprehensive experiments on the real dataset we build demonstrate the effectiveness of CH-RNN and benefit of considering social texts.
Environmental Regulation, Two-Way Foreign Direct Investment, and Green Innovation Efficiency in China’s Manufacturing Industry

This paper adopts 2009 to 2015 panel data from 27 manufacturing industries in China. A Super-SBM model is used to measure the green innovation efficiency (GIE) of China’s manufacturing industry. A panel data model is then built to systematically examine the impact of environmental regulation (ER) and two-way foreign direct investment (FDI) on the GIE of China’s manufacturing industry under a unified analysis framework. The results are as follows: (1) the overall level of the green innovation efficiency in China’s manufacturing is low, and there is still great potential for improvement. Considering industry heterogeneity, the green innovation efficiency of patent-intensive manufacturing is significantly higher than that of non-patent-intensive manufacturing; (2) in terms of the whole manufacturing industry, ER and the interaction between ER and outward foreign direct investment (OFDI) have significantly negative effects on GIE, OFDI has significantly positive effects on GIE. (3) when considering industry heterogeneity, for patent-intensive manufacturing, ER and the interaction between ER and inward foreign direct investment (IFDI) have significantly negative effects on GIE, while IFDI has significantly positive effect on GIE. For non-patent-intensive manufacturing, ER and the interaction between ER and OFDI have significantly negative effects on GIE, while IFDI and the interaction between ER and IFDI have significantly positive effects on GIE.
Differing efficacies of autologous platelet-rich plasma treatment in reducing pain following rotator-cuff injury in a single patient

Rotator-cuff tears (RCTs) are typically associated with chronic pain. The most common treatment for reducing pain is the injection of cortisone into the injury site. An alternative and increasingly used technique is the injection of autologous platelet-rich plasma (PRP). A limitation of cortisone is its pain relief is short-lived, while PRP has the limitation of providing pain relief to only about 50% of patients, making its efficacy questioned, although when it is effective, its efficacy is longer than cortisone. Little is known about what accounts for these limitations. This paper presents results from a patient with RCTs causing excruciating pain who received an injection of PRP into that shoulder resulting in complete pain elimination that was ongoing at 2 years and 2 months. When 7-month severe posttrauma pain associated with the RCT developed in the contralateral shoulder, PRP prepared the same way and injected by the same person who performed the first injection provided no pain relief. However, a subsequent single cortisone injection resulted in complete pain elimination, which was ongoing at >15 months. These observations indicate that PRP can have inconsistent effects in reducing pain, not only between patients but also within the same patient. Further, although the pain relief induced by cortisone is normally not long-lasting, when given following a PRP injection, it can induce complete pain relief lasting >15 months. This paper discusses possible reasons for the variability in PRP efficacy on pain relief and addresses the possibility that when administered together, PRP and cortisone may act in a complementary manner, leading to significantly greater and longer-lasting pain relief.
Contribution of the Oligomeric State to the Thermostability of Isoenzyme 3 from Candida rugosa

Thermophilic proteins have evolved different strategies to maintain structure and function at high temperatures; they have large, hydrophobic cores, and feature increased electrostatic interactions, with disulfide bonds, salt-bridging, and surface charges. Oligomerization is also recognized as a mechanism for protein stabilization to confer a thermophilic adaptation. Mesophilic proteins are less thermostable than their thermophilic homologs, but oligomerization plays an important role in biological processes on a wide variety of mesophilic enzymes, including thermostabilization. The mesophilic yeast Candida rugosa contains a complex family of highly related lipase isoenzymes. Lip3 has been purified and characterized in two oligomeric states, monomer (mLip3) and dimer (dLip3), and crystallized in a dimeric conformation, providing a perfect model for studying the effects of homodimerization on mesophilic enzymes. We studied kinetics and stability at different pHs and temperatures, using the response surface methodology to compare both forms. At the kinetic level, homodimerization expanded Lip3 specificity (serving as a better catalyst on soluble substrates). Indeed, dimerization increased its thermostability by more than 15 °C (maximum temperature for dLip3 was out of the experimental range; >50 °C), and increased the pH stability by nearly one pH unit, demonstrating that oligomerization is a viable strategy for the stabilization of mesophilic enzymes.
Human Behavior Understanding: From Action Recognition to Complex Event Detection

Analyzing human behaviour in videos is one of the fundamental problems of computer vision and multimedia understanding. The task is very challenging as video is an information-intensive media with large variations and complexities in content. With the development of deep learning techniques, researchers have strived to push the limits of human behaviour understanding in a wide variety of applications from action recognition to event detection. This tutorial will present recent advances under the umbrella of human behaviour understanding, which range from the fundamental problem of how to learn "good" video representations, to the challenges of categorizing video content into human action classes, finally to multimedia event detection and surveillance event detection in complex scenarios.
Does the 18‐h sperm motility influence intrauterine insemination results?

Dear Editor Sperm quality has a major influence on the results of intrauterine inseminations (IUI), especially through the number of motile spermatozoa recovered after preparation and their morphology (Wainer et al., 2004). Another sperm parameter reported to impact IUI results was sperm motility after 18 h or 24 h incubation (so-called sperm survival by approximation) in culture media after preparation with a drop in pregnancy rate from 21% if survival is >70% to less than 4% when it is ≤70% (Branigan et al., 1999). However, there is no recent data on this subject and in their systematic review on the effect of semen quality on IUI results, Ombelet et al. have found no other paper on sperm survival since the one of Branigan et al. published in 1999 (Ombelet et al., 2014). Therefore, we aimed to revisit the concept of a deleterious impact of low sperm survival on IUI outcome. The study included 1793 consecutive IUI performed in 713 couples at the Toulouse university hospital from January 1, 2012 to December 31, 2016. Ovarian stimulation used a combination of recombinant FSH and GnRH antagonist. Ovulation was induced by injection of recombinant hCG when at least one follicle ≥18 mm was obtained. Insemination was performed 36 h after hCG injection. Clinical pregnancies were defined as the presence of a fetal heartbeat seven weeks after insemination. Semen analysis was performed within six months before the first IUI. After conventional analysis (volume, concentration, and motility), spermatozoa were prepared according to WHO 2010 using discontinuous density gradient centrifugation (three layers: 60%, 80%, 90%) (Puresperm , Nidacon, M€ olndal, Sweden). After preparation, spermatozoa were incubated in 400 lL universal IVF medium (Origio, Versailles, France) at 37 °C in a 6% CO2 atmosphere. Motility was assessed after a 18 h incubation. Sperm preparation on the day of IUI was performed in the same way. The clinical pregnancy rate per attempt was not different according to the 18 h motility classes (defined by centiles) (13.4% for motility <25%, 15.5% for 25% < motility < 45%, 12.1% for 45% < motility < 60%, 15.0% for 60% < motility < 70%, 15.3% for 70% < motility < 80%, and 16.5% for motility ≥ 80%; NS). This finding is opposite to the results published by Branigan et al., who reported a pregnancy rate per cycle lower than 4% when the motility after a 24 h incubation was lower than 70%. However, the proportion of low survival rate (<20%) is much lower in our study (<10%) than in their study (Table 1) (36%) although they adjusted sperm concentration to a maximum of 10 millions motile sperm per milliliter for evaluating sperm survival which should have help maintain it. This difference could reflect discrepancies in the treated population and/or in techniques. Indeed, in the 20 years between the two studies, numerous modifications have been carried out concerning gradient as well as media. It must be pointed out that in the
Text Analysis of Cases Description in Urban Management Field Based on Knowledge Atlas

With1 the development of information technology, Chinese urban Management has entered the information age. There will be a large number of cases with unstructured text which are reported by city officers and citizens entering into the digital platform, processing these text only by traditional method such as searching by key words will not only consume a lot of energy and time, but also be difficult to generalize the core issues of urban management because of the lost of the relationships between entities and events. In this paper, we propose a domain-oriented method to analyze the text using the domain-oriented knowledge graph and BLSTM-CRF model. we define a new graph structure to grasp the syntactical pattern and core concepts of this field by the method of hierarchical LDA (H-LDA). Combing the BLSTM-CRF language processing model with the domain knowledge graph, key entities and the corresponding description phrase are extracted from the text and recomposed as a short description. We make a further statistical analysis on the basic of the descriptions and semantic labels to find problems that affecting urban development and put forward pertinent suggestions.
The Protective Effect of Polygonum cuspidatum (PCE) Aqueous Extract in a Dry Eye Model

Dry eyes are caused by highly increased osmolarity of tear film, inflammation, and apoptosis of the ocular surface. In this study, we investigated the effect of Polygonum cuspidatum (PCE) aqueous extract in in vivo and in vitro dry eye models. Dry eye was induced by excision of the lacrimal gland and hyperosmotic media. In vivo, oral administration of PCE in exorbital lacrimal gland-excised rats recovered tear volume and Mucin4 (MUC4) expression by inhibiting corneal irregularity and expression of inflammatory cytokines. In vitro, hyperosmotic media induced human corneal epithelial cell (HCEC) cytotoxicity though increased inflammation, apoptosis, and oxidative stress. PCE treatment significantly inhibited expression of cyclooxygenase-2 and inflammatory cytokines (interleukin-6 and tumor necrosis factor-α), and activation of NF-κB p65 in hyperosmolar stress-induced HCECs. Hyperosmolarity-induced increase in Bcl-2-associated X protein (BAX) expression and activation of cleaved poly (ADP-ribose) polymerase and caspase 3 were attenuated in a concentration-dependent manner by PCE. PCE treatment restored anti-oxidative proteins such as heme oxygenase-1 (HO-1), superoxide dismutase-1 (SOD-1), and glutathione peroxidase (GPx) in hyperosmolar stress-induced HCECs. These data demonstrate that PCE prevents adverse changes in the ocular surface and tear fluid through inhibition of hyperosmolar stress-induced inflammation, apoptosis, and oxidation, suggesting that PCE may have the potential to preserve eye health.
3D Face Recognition Based on Empirical Mode Decomposition and Sparse Representation

With1 the research interest increasing in 3D face recognition, many methods for 3D face recognition have emerged in recent years. In this paper, a novel method named as decomposition-based face classification (DFC) is proposed to recognize a 3D face by using empirical mode decomposition (EMD) and sparse representation. A 3D face scan is firstly decomposed into several surfaces by a 3D EMD algorithm, then for each decomposed surface, meshSIFT is used for detecting salient points and extracting the local descriptor, and the dictionary is constructed by concatenating all the local descriptors. Finally, the identification of a probe face can be determined by the multitask sparse representation classification. Experimental results demonstrate that our decomposition-based method can achieve state-of-the-art performance on two benchmark databases, Bosphorus and FRGC2.0.
3’Igh enhancers hs3b/hs4 are dispensable for Myc deregulation in mouse plasmacytomas with T(12;15) translocations

Myc-deregulating T(12;15) chromosomal translocations are the hallmark cytogenetic abnormalities of murine plasmacytomas (PCTs). In most PCTs, the immunoglobulin heavy chain (Igh) locus is broken between the Eμ enhancer and the 3’ regulatory region (3’RR), making the latter the major candidate for orchestrating Myc deregulation. To elucidate the role of the Igh3’RR in tumorigenesis, we induced PCTs in Bcl-xL-transgenic mice deficient for the major Igh3’RR enhancer elements, hs3b and hs4 (hs3b-4-/-). Contrary to previous observations using a mouse lymphoma model, which showed no tumors with peripheral B-cell phenotype in hs3b-4-/- mice, these animals developed T(12;15)-positive PCTs, although with a lower incidence than hs3b-4+/+ (wild-type, WT) controls. In heterozygous hs3b-4+/- mice there was no allelic bias in targeting Igh for T(12;15). Molecular analyses of Igh/Myc junctions revealed dominance of Sμ region breakpoints versus the prevalence of Sγ or Sα in WT controls. Myc expression and Ig secretion in hs3b-4-/- PCTs did not differ from WT controls. We also evaluated the effect of a complete Igh3’RR deletion on Myc expression in the context of an established Igh/Myc translocation in ARS/Igh11-transgenic PCT cell lines. Cre-mediated deletion of the Igh3’RR resulted in gradual reduction of Myc expression, loss of proliferative activity and increased cell death, confirming the necessity of the Igh3’RR for Myc deregulation by T(12;15).
Overnight Steady-State Infusions of Parenteral Nutrition on Myosin Heavy Chain Transcripts in Rectus Abdominis Muscle Related to Amino Acid Transporters, Insulin-like Growth Factor 1, and Blood Amino Acids in Patients Aimed at Major Surgery.

BACKGROUND Evaluation of improvements by nutrition support to severely ill patients requires sensitive methods to demonstrate activation of protein synthesis in various tissues from groups with a limited number of patients to be statistically efficient. This study examines effects of standard parenteral nutrition (PN) on abdominal muscle transcripts of amino acid (AA) transporters, myosin heavy chains (MHCs), and the insulin-like growth factor 1 and its receptor (IGF-1/IGF-1R) in patients aimed at major surgery. METHODS Twenty-two randomized patients received steady-state PN (0.16 gN/kg/d, 30 kcal/kg/d) or saline infusions for 12 hours before operation. Blood samples and muscle biopsies were obtained at operation start. Muscle messenger RNA (mRNA) levels of AA transporters (solute carrier family members SNAT2, LAT1, LAT3, LAT4, TAUT, PAT1, CD98), IGF-1, IGF-1R, MHC isoforms (MHC1, MHC2A, MHC2X), and LAT3 protein were quantified and related to concentrations of AA, IGF-1, insulin, and metabolic substrates in blood. RESULTS Muscle mRNA LAT3, LAT4, IGF-1R, and MHC2A increased by PN infusion, with correlations to specific AA transporters and MHC isoforms (P < .01-.05). TAUT and LAT3 correlated to slow (MHC1) and fast (MHC2A, MHC2X) isoforms (P < .001-.02). Muscle IGF-1 mRNA correlated to plasma essential AAs, whereas IGF-1R mRNA was related to LAT3, MHC2A, and serum IGF-1 (P < .001-.03). CONCLUSIONS The results confirm that short-term preoperative PN activates transcription of AA transporters and myosin isoforms. Thus, combinations of methods on gene transcription and translation of muscle proteins can be applied to define efficient combinations of nutrition and hormones to catabolic patients in preoperative and postoperative settings.
The Finite Element Method and Its Computational Effectiveness for Solving Semilinear Singularly Perturbed Two-point Boundary Value Problems Using Shishkin Mesh

In1 this paper, we consider the numerical method for solving a class of semilinear singularly perturbed two point boundary value problems. First based the interpolation coefficient finite element method on the ShiShkin mesh is introduced to solve such problems. Secondly, we deduce the error estimate of the numerical method. Then the validity of the interpolation finite element method is verified by numerical example.
Understanding extracellular vesicle diversity – current status

ABSTRACT Introduction: Extracellular vesicles (EVs) represent an important mode of intercellular communication. There is now a growing awareness that predominant EV subtypes; exosomes from endosomal origin, and shed microvesicles from plasma membrane budding, can be further stratified into distinct subtypes, however specific approaches in their isolation and markers that allow them to be discriminated are lacking. Areas covered: Knowledge about these distinct EV subpopulations is important including the regulation of composition, release, targeting/localization, uptake, and function. This review discusses the mechanisms of distinct EV biogenesis and release, defining select EV classes (and subpopulations), which will be crucial for development of EV-based functions and clinical applications. We review the dynamics of cargo sorting leading to the mechanisms of EV heterogeneity, their mechanisms of formation, intracellular trafficking pathways, and provide an uptake about biochemical/functional differences. With advances in purification strategies and proteomic-based quantitation, allows significant benefit in accurately describing differences in EV protein cargo composition and modification. Expert commentary: The advent of quantitative mass spectrometry-based proteomics, in conjunction with advances in molecular cell biology, and EV purification strategies, has contributed significantly to our improved characterization and understanding of the molecular composition and functionality of these distinct EV subpopulations.
Introducing Flavorlens: A Social Media Platform for Sharing Dish Observations

In this paper, we present Flavorlens, a mobile application for sharing dish observations. Each observation consists of one or more photographs, a title, a location tag, a description, a rating, a sensoring experience reporting about flavors, textures, and odors of a particular dish. Finally, we describe the design and implementation of our system which is based on a requirement analysis.
Digital cholangioscopy: the diagnostic yield and impact on management of patients with biliary stricture

Abstract: Objectives: Biliary strictures frequently present a diagnostic challenge. The aim of this study was to evaluate the impact of digital single-operator cholangioscopy (DSOC) on subsequent treatment of patients with biliary stricture. Methods: Consecutive patients undergoing DSOC for biliary stricture were enrolled. Gold standard for final diagnosis included histology from surgical resection. In patients without surgery, clinical evaluation methods and repeated imaging studies were used for comparison of DSOC findings and final diagnosis. Patients were followed-up prospectively focusing on subsequent treatment. Results: Among 30 enrolled patients, final diagnosis was malignant in 13 (43%) and benign in 17 (57%). The sensitivity and specificity of visual impression in diagnosing malignant stricture were 100% (95% CI: 75 − 100) and 76% (95% CI: 50 − 93), respectively. The sensitivity and specificity for biopsy were 92% (95% CI: 62 − 100) and 100% (95% CI: 78 − 100), respectively. One (3%) case of complicating cholangitis with fatal outcome occurred. Final treatment included surgery in 7 (23%), endoscopy in 18 (60%) and chemotherapy in 3 (10%) of patients. Conclusions: In this study, favorable operating characteristics of DSOC were confirmed. Absolute negative predictive value of visual impression provided reassurance to patients with benign strictures who avoided unnecessary surgery in 53%. One (3%) case of cholangitis with fatal outcome occurred.
Legume Protein Consumption and the Prevalence of Legume Sensitization

Sensitization and allergy to legumes can be influenced by different factors, such as exposure, geographical background, and food processing. Sensitization and the allergic response to legumes differs considerably, however, the reason behind this is not yet fully understood. The aim of this study is to investigate if there is a correlation between legume protein consumption and the prevalence of legume sensitization. Furthermore, the association between sensitization to specific peanut allergens and their concentration in peanut is investigated. Legume sensitization data (peanut, soybean, lupin, lentil, and pea) from studies were analyzed in relation to consumption data obtained from national food consumption surveys using the European Food Safety Authority (EFSA), Global Environment Monitoring System (GEMS), and What We Eat in America—Food Commodity Intake Database (WWEIA-FCID) databases. Data were stratified for children <4 years, children 4–18 years, and adults. Sufficient data were available for peanut to allow for statistical analysis. Analysis of all age groups together resulted in a low correlation between peanut sensitization and relative peanut consumption (r = 0.407), absolute peanut consumption (r = 0.468), and percentage of peanut consumers (r = 0.243). No correlation was found between relative concentrations of Ara h 1, 2, 3, 6, 7, and 8 in peanut and sensitization to these peanut allergens. The results indicate that the amount of consumption only plays a minor role in the prevalence of sensitization to peanut. Other factors, such as the intrinsic properties of the different proteins, processing, matrix, frequency, timing and route of exposure, and patient factors might play a more substantial role in the prevalence of peanut sensitization.