Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor-Targeting Bacteria: As Vectors, Immunotherapeutic Agents And Tumor-Targeting Probes For Cancer Detection And Therapy

DOI: http://dx.doi. org/10.24018/ejmed.2020. 2.3. 337 Vol 2 | Issue 3 | June 2020 1 Abstract — Cancer is the world's second leading cause of death in humans. Conventional anticancer therapies are often associated with lack of tumor specificity, failure to detect small metastases, increased resistance of tumors to anticancer drugs, and unintended adverse effects. Numerous alternative and better strategies in cancer treatment have been developed to overcome the negative effects of traditional cancer therapies. More than a century ago, William Coley, the father of cancer immounotherapy, laid the groundwork for bacterial anticancer therapy. Bacterial immunotherapy has been emerging as a potential anticancer therapy. Moreover, certain obligate and facultative anaerobic bacterial species are exploited as vectors for gene delivery to treat cancer. These genes encode for anticancer agents, cytokines, cytotoxic peptides, antiangiogenic proteins, therapeutic molecules and prodrugconverting enzymes. Genetically engineered bacterial strains of Salmonella, Bifidobacterium, Clostridium and Listeria are widely used to deliver genes in anticancer therapy since they can selectively accumulate in solid tumors with a hypoxic/necrotic core in vivo, providing appealing delivery systems to target therapeutic agents and immunomodulatory molecules to the site of tumor. Certain genetically modified bacterial species such as Bifidobacterium longum and Bacillus licheniformis have been effectively used for the enzyme/prodrug therapy for cancer. Furthermore, certain anaerobic bacteria are emerging as potential tumor markers due to the increased mobility and the selectivity in germinating and multiplying in hypoxic/anoxic environments. Many of these novel developments have been studied extensively in different experimental models of cancer and certain clinical trials are ongoing for some treatment modalities. Although favourable results have shown so far, further studies and technological innovations are required to ensure the efficacy of bacterial anticancer therapy.
A Comparison of EFL Fifth Graders’ Vocabulary Acquisition through Skype Videoconferencing and Face-to-face Picture Book Storytelling

This quasi-experimental study explores the relative efficacy of computer-mediated communication (CMC) and face-to-face picture book storytelling for promoting young EFL learners’ English word acquisition. Thirty-two young EFL learners participated in a 40-minute story session in the two aforementioned modes. Receptive and productive word gains were assessed through immediate and delayed receptive vocabulary tests and productive story recall tests. To better explain how the CMC and face-to-face settings affected the participants’ word gains, their involvement in the two types of storytelling settings was evaluated using an involvement load survey. The results show that the participants’ task involvement was higher in the face-to-face setting than the CMC setting, which led to better word gains. Within each setting, high-involvement participants’ word gain was better than that of their low-involvement counterparts. However, the difference between high-involvement and low-involvement participants was only manifest in the receptive word gains for the participants in the CMC setting, but not the productive word gains. These findings suggest that face-to-face storytelling might be the more effective setting when picture book storytelling is adopted to promote EFL young learners’ word gains, especially for receptive word gains.
Life Style Guideline of Ginger (Zingiber officinale) as Prophylaxis and Treatment for Coronaviruses (SARS-CoV-2) Infection (COVID-19)

Coronaviruses which are enveloped RNA viruses infect human causing acute and chronic diseases also cause severe acute respiratory syndrome coronavirus (SARS-CoV) and common cold. The aim of this review is to concentrate on ginger which has many benefits to human, as the traditional medicine for the prophylaxis and treatment of COVID-19. In spite of spreading of COVID-19 all over the world, the incidence of the disease among Sudanese people still very low, most probably for their daily habit in using ginger as the traditional herbal drink in their life style. I believe that Ginger is the most effective traditional medicine for prophylaxis and treatment of COVID-19 for its properties in improving immune system and fighting corona viruses, more studies should be conducted to prove this thought.
REAL-TIME MONITORING OF CELL CULTURES WITH NICKEL COMB CAPACITORS

The aim of the study was to present a method for assessing the condition of cell culture by measuring the impedance of cells cultured in the presence of nickel. For this purpose, an impedance measurement technique using nickel comb capacitors was used. The capacitor electrodes were made using a thin film magnetron sputtering. In the experimental part, the culture of cells of mouse fibroblasts on the prepared substrate was performed. The cell culture lasted 43 hours and showed that the presented technique allows it to be used to analyze the effect of nickel on cells.
Dry Matter Production and Nutritional Status of Sunflower Grown in Nutrient Solution under Macronutrient Omission

The objective of this study was to evaluate the effect of omission of macronutrients on dry matter production and on the nutritional status of sunflower cv. BRS 122. The experiment was carried out in a greenhouse, in randomized blocks, with seven treatments corresponding to the Hoagland & Arnon standard solution (1950) and the individual omission of N, P, K, Ca, Mg and S, in three replicates. After 50 days of sowing, the dry matter and the nutritional status of the plants were evaluated. The omission of N, P, K, Ca, Mg and S limited the dry mass production of sunflower cv. BRS 122 in relation to the complete solution, besides causing nutritional imbalance due to the interaction between the nutrients. The omission of the macronutrients K, Ca, and Mg caused the higher imbalances in the plants, highlighting the elevated N contents in these treatments comparing to the complete solution.
Crystal Structure of the putative tail fiber protein gp53 from the Acinetobacter baumannii bacteriophage AP22

This report describes the structure of a putative tail fiber protein of the Acinetobacter baumannii bacteriophage AP22. The target host range of strictly lytic bacteriophage AP22 includes many clinical isolates of A. baumannii from hospitals in Chelyabinsk, Nizhny Novgorod, Moscow and St. Petersburg (Russia), but its host cell binding apparatus remains uncharacterized. Here, we report the crystal structure of the C-terminal fragment of AP22 gene product 53 (gp53) one of its two putative host cell-binding proteins. We show that gp53 forms a trimeric fiber and binds ethylene glycol and glycerol molecules that represent known surrogates of the oligosaccharide backbone. However, despite its structural similarities to other phage/virus host cell-binding fibers and its binding to small sugar-like molecules, gp53 did not inhibit AP22 infection and its role in the infection process remains unclear.
THE XBRL TECHNOLOGY AND MARKET EFFICIENCY IN BANKING COMPANIES LISTED ON THE INDONESIA STOCK EXCHANGE (IDX)

The problem in this research is the need for fast and accurate information in the format of the presentation of financial statements resulting in the distribution of information, and data management can be problematic. Therefore, a format for financial reporting systems, namely Extensible Business Reporting Language (XBRL), was formed. The purpose of this study was to determine the effect of XBRL technology, stock prices, Return on Assets (ROA), and institutional ownership on market efficiency (information asymmetry and stock trading volume). The population and sample of this study are banking companies listed on the Indonesia Stock Exchange from 2015-2016. The sampling method using a purposive sampling method and obtained a sample of 42 companies. Data collection techniques are carried out by taking data from the Indonesia Stock Exchange website (www.idx.co.id) and the site http://finance.yahoo. com. Data were analyzed with multiple regression tests after being declared normal with the normality test and though using SPSS 20. The results of this study simultaneously stated that XBRL technology, stock prices, ROA, and institutional ownership together have an influence on information asymmetry and stock trading volume. From the results of the study, it can be concluded that XBRL technology, stock prices, ROA, and institutional ownership cause a decrease in the level of information asymmetry and trading volume. This result also states that the company is in excellent condition when the value of information asymmetry decreases, but it is not good when the trading volume of its shares also decreases. Keywords: XBRL Technology; Stock Prices; Market Efficiency; Information Asymmetry; Stock Trading Volume.
Extraction of Essential Oil from Indigenous Herb Physalis angulata Linn using Microwave Assisted Extraction

Essential oil is a kind of remedy that is originated from various part of plants. One of them is Physalis angulata Linn that is beneficial to human health yet very scarce explored by researchers. In this work, extraction of this herbal essential oils using microwave-assisted extraction (MAE) is proposed as an alternative greener extraction technique. The objective of this study is to determine the effect of extraction time (4, 6, 8, 10 and 12 min), liquid-to-solid ratio (ranging from 8 to 16 ml/g) and microwave power (270, 360, 450, 540 and 630 W) on the extraction yield of oil from Physalis angulata Linn . Results showed that the optimum operating condition of MAE of this herb that gave the maximum 21 wt% yield of essential oil was found when extracted in 12 minutes for duration of extraction time using 12 ml/g for liquid-to-solid ratio and 630 W of microwave power. GC-MS results presented the highest constituent of 4,5-Dichloro-ortho-phenylenediamine (24.07 min), Diethyl Phthalate (24.09 min) and Phthalic acid, ethyl 2-pentyl ester (24.09 min) with percentage of 4.10 %. These results demonstrated that Physalis angulata Linn essential oil possess of health beneficial phytocompounds that exhibits as antimicrobial, anticancer and anti-toxic agent.
Assessment of the Impact of Civil Engineering Design Problems for Promoting Ethical Decisions

Dr. Sarah Bauer is an Assistant Professor in the Department of Civil and Environmental Engineering at Rowan University. Dr. Bauer holds a doctoral degree in Civil and Environmental Engineering from the University of Virginia, Charlottesville. Dr. Bauer is the recipient of numerous awards and scholarships as a young professional. Her primary research interests are: water and wastewater treatment, renewable energy technologies, and pollution prevention. She has worked on a variety of educational projects to enhance environmental engineering education while at Rowan University. Dr. Bauer is an active member of ASEE and the Society of Women Engineers (SWE) and currently serves as the Faculty Advisor for Rowan’s Student Chapter of SWE.
Stability of TSWV General Field Resistance in the ‘Georgia Green’ Peanut Cultivar

Branch, W. D. , and Culbreath, A. K. 2015. Stability of TSWV general field resistance in the ‘Georgia Green’ peanut cultivar. Plant Health Progress doi:10.1094/PHP-RS-15-0007. There are mainly two types of host-plant disease resistance. General or horizontal resistance is usually controlled by several genes each acting with minor additive effects, and specific or vertical resistance is usually controlled by one or two genes with a dominant major effect. In most cases, general resistance may not provide as high a level of control as specific; however, general type of resistance is usually more desirable for long-term stability. Therefore, the objective of this 13-year study was to determine the stability of the general disease resistance to tomato spotted wilt (TSW), caused by Tomato spotted wilt virus (TSWV), found in the peanut (Arachis hypogaea L.) cultivar ‘Georgia Green’, as indicated by comparisons with the highly susceptible ‘Florunner’ cultivar. The general host-plant TSWV resistance of Georgia Green was found to have consistently lower TSW at mid-season and total disease (primarily TSW and any soilborne disease) incidence at late season, respectively, and higher pod yield compared to Florunner across all 13 years without any genotype-by-year (G×Y) interaction for these variables. Consequently, the general TSWV-resistance of Georgia Green was found to be highly stable across many years, and should be utilized for progress in breeding improved TSWV-resistant peanut cultivars.
A nonparametric approach for setting safety stock levels

In practice, lead time demand (LTD) can be skewed, multi‐modal or highly variable, and these factors compromise the validity of typical approaches used for setting safety stock levels. Motivated by encountering this problem at our industry partner, we develop an approach for setting safety stock levels using the bootstrap, a widely used statistical procedure. Existing bootstrap approaches for inventory management either operate directly on observed LTD or assume deterministic lead times, permitting direct application of the bootstrap approach for univariate quantile estimation. As LTD is a convolution of multiple random demands over a random lead time, a multivariate bootstrap approach is required. As we demonstrate, when lead times are stochastic, our multivariate approach provides improved safety stock estimates. We develop a multivariate central limit theorem for the bootstrap mean and bootstrap quantile—components of the safety stock calculation—highlighting why the generalization of these bootstrap methods is critical for inventory management. These results provide a theoretical underpinning for the bootstrap estimator of safety stock and permit the construction of confidence intervals for safety stock estimates, allowing decision makers to understand the reliability with which the desired service level will be achieved. Building on our theoretical results, and supported by numerical experiments, we provide insights on the behavior of the bootstrap for various LTD distributions, which our results demonstrate are critical when employing the bootstrap method. Implementation of our approach with our industry partner resulted in an inventory investment reduction of $1.17 million combined with an overall increase in service level. Our approach is general and can be implemented without modification in other settings.
Parent Training and Communication Empowerment of Children With Cochlear Implant

Deaf children with cochlear implants (CIs) need a supportive family environment to facilitate language development. The present study was designed to assess the effects of parent training (PT) on enhancing children’s communication development. The PT was based on the “It Takes Two to Talk” model, with specific adaptations for families of deaf children. Before and after the PT, 14 participating families and matched no-treatment controls were assessed using the Parent Stress Index and Cole’s interaction checklist. The children’s language was assessed with the MacArthur–Bates Communicative Development Inventory and, after 3 years, with the Boston Naming, the Peabody, and the Test for Reception of Grammar–Version 2 (TROG-2). The families’ quality of interaction and the children’s language increased significantly more in the trained group than in controls and differences were still present after 3 years. The parents seemed to benefit from PT that focused on strategies to empower and promote communication skills in children with CIs.
Taxonomic status and distribution of Mirabilis himalaica (Nyctaginaceae)

Mirabilis himalaica (Edgew.) Heimerl (Nyctaginaceae) is endemic to the Himalayas where it is used in traditional Tibetan folk medicine and is the only Old World representative of a large New World genus. The systematic position of M. himalaica and historical biogeography of Mirabilis and related genera was evaluated using two loci (nuclear ribosomal internal transcribed spacer, rps16), with divergence times estimated using internal transcribed spacer sequences. All 16 sampled provenances of M. himalaica formed a strongly supported terminal clade and at the sectional level formed a clade with sect. Quamoclidion sensu stricto, despite their morphology. Section Oxybaphoides and sect. Oxybaphus were not closely related to M. himalaica, suggesting their apparent morphological similarities are convergent. The beast analysis and ancestral area reconstruction indicated that M. himalaica separated from related North American species during the late Miocene to early Pleistocene ∼5.22 Ma (95% highest posterior density, 2.53–8.18). Both migration by way of the Quaternary Bering land bridge (Beringia) and long‐distance dispersal could have contributed to the present‐day disjunction between M. himalaica and the American species. These results agree with previous studies that suggest Oxybaphus should be merged into Mirabilis. However, although the infrageneric position of M. himalaica is still uncertain, it is not close to sect. Oxybaphus as has been suggested previously.
Lower bound for average delay in unblocked random access algorithm with orthogonal preambles

Introduction: Currently, the first versions of 5G communication standard networks are being deployed and discussions are underway on the further development of cellular networks and the transition to the 6G standard. The work of the currently popular idea of ​​the Internet of Things (IoT) is supposed to be in the framework of a Massive Machine-Type Communications scenario, which has a number of requirements for operation characteristics: very high energy efficiency, relatively low delay and fairly reliable communication. It is assumed that random multiple access procedures are used, since, due to the nature of the traffic, it is impossible to develop a channel resource sharing policy. To increase the efficiency of random access, a class of unblocked algorithms using orthogonal preambles can be used. Purpose: to calculate the lower bound of the average delay for the class of unblocked random multiple access algorithms using orthogonal preambles. Methods: system analysis, a theory of random processes, queuing theory, and simulation. Results: A model of a system with a potentially unlimited number of users who use random unblocked access to transmit data over a common communication channel using orthogonal preambles is proposed. A closed expression is obtained for calculating the lower bound of the average delay in such a system depending on the intensity of the input arrival rate. The limit value of the intensity of the input arrival rate to which the system operates stably is determined. Shown are the results of simulation with respect to the obtained bound. Practical relevance: the obtained boundary allows us to estimate the lower average delay in the described class of algorithms. Its application allows us to determine the possibility of using the considered class of algorithms from the point of view of limitations on the average delay at the stage of designing random multiple access systems.
PENENTUAN RUMUS PERCEPATAN TANAH AKIBAT GEMPABUMI DI KOTA MATARAM MENGGUNAKAN METODE EUCLIDEAN DISTANCE

Wilayah Lombok khususnya Kota Mataram dikategorikan sebagai kawasan dengan kerentanan tinggi terhadap gempabumi. Kota Mataram dikelilingi oleh beberapa zona sumber gempa termasuk subduksi dan back arc thrust. Peak Ground Acceleration (PGA) merupakan suatu parameter yang bisa menggambarkan dampak dari gempabumi. Pada penelitian ini kami menentukan persamaan terbaik untuk memperkirakan PGA di antara beberapa model yang ada. Metode yang digunakan untuk memilih persamaan adalah analisa residual dan Euclidean Disteance Ranking. Data yang digunakan terdiri atas nilai PGA dari accelerograph di Stasiun Geofisika Mataram (MAKE), katalog gempabumi di sekitar Mataram pada periode 2016 hingga 2018, dan kondisi situs di MAKE. Hasil penelitian menunjukkan bahwa beberapa persamaan memiliki hubungan yang baik dengan PGA hasil observasi di Kota Mataram yang penting untuk mitigasi gempabumi.
Immunobioinformatics analysis and phylogenetic tree construction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Indonesia: spike glycoprotein gene

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has spread worldwide and as a result, the World Health Organization (WHO) declared it a pandemic. At present, there are no approved vaccines against SARS-CoV-2. Therefore, the aim of this study was to predict epitope-based vaccines using bioinformatics approaches and phylogenetic tree construction of SARS-CoV-2 against the backdrop of the COVID-19 pandemic. In this study, we employed 27 isolates of SARS-CoV-2 spike glycoprotein genes retrieved from GenBank® (National Center for Biotechnology Information, USA) and the GISAID EpiCoV™ Database (Germany). We analyzed the candidate epitopes using the Immune Epitope Database and Analysis Resource. Furthermore, we performed a protective antigen prediction with VaxiJen 2.0. Data for B-cell epitope prediction, protective antigen prediction, and the underlying phylogenetic tree of SARS-CoV-2 were obtained in this research. Therefore, these data could be used to design an epitope-based vaccine against SARS-CoV-2. However, the advanced study is recommended for confirmation (in vitro and in vivo).
Construction of a prototype for tracking dogs in the streets using Arduino

One of the motives that compromises the welfare of dogs is a lack of understanding of their needs and of the natural behavior of the species. The use of telemetry as a means of indirect observation is emergent and has provided a significant increase in scientific perspectives. However, its use is still limited for domestic animals despite the high potential for applying the technology in this area. Thus, the objective of this project was to construct a prototype using telemetry via satellite, of reduced size and low cost that allows for the monitoring of dogs in the streets. The prototype of the tracker was constructed containing a Pro Mini Arduino with an ATmega328 micro-controller, a GPS module for the Arduino, GPS u-blox NEO-6M and a Micro Sd reading/taping module for the Arduino. The final weight of the prototype was 197.4±101.5 grams with the battery and is attached to the collar. The dispersion of the planimetric coordinates around the mean was 2.7 meters, which increased to 10.9 meters when the height factor was added to the dispersion. It was concluded that with the size and weight of the prototype used it was possible to evaluate medium to large-sized dogs in the street. The prototype showed the precision necessary to read the coordinates collected for projects aimed at monitoring dogs in the streets, since these do not demand millimetric precision and accuracy.