Miracle-dz/UniFAR-FTUs huggingface dataset:
PERFORMANCE EVALUATION OF M-PDDRA ALGORITHM UNDER PRIORITIZED TRAFFIC

Database replication is a process, which keeps the multiple copies of the same data at a different geographical location, thus allowing data security and reduces load and access delay. In the recent past PDDRA, a pre-fetching based dynamic data replication algorithm was proposed and later on further modifications are done to increase throughput and reduce latency. In previous work, the performance of the algorithms is measured for random traffic arrival process for both local and global network. The performance is also evaluated under load balancing condition. However, an important feature in request generation is a priority of the request, which needs to be addressed. This work considers the priority of generated requests in request loss analysis, and thus it lifts the assumption of the previous algorithm which assumes that member of the virtual organization has similar interest. The performance evaluation of the algorithm is performed using Monte-Carlo simulation.
Ant Colony Optimization Algorithm For Protein Folding Problem On Graphics Processing Units

: This article describes the methods of modification and parallelization of ant colony optimization algorithm for the protein folding problem. It describes in detail the software implementation of parallel ant colony optimization algorithm on the graphics processing units. Index Terms : ant colony optimization algorithm, graphics processing units, protein folding problem. ——————————  ——————————
Automatic data analysis within X-ray inspection of welds

In this paper, different approaches to automatic and semi-automatic data analysis within X-ray inspection of welds have been reviewed. The reason for the limited number of industrial implementations of such automatic data analysis solutions within the quality critical manufacturing industry segment (e.g. aerospace and oil and gas industry) has then been analyzed. A conceptual solution for semiautomatic data analysis, potentially more suitable for industrial implementation in such quality critical applications, has been outlined and proposed together with a set of identified research gaps that require attention. Our proposed solution is semiautomatic rather than fully automatic. It leverages recent developments in machine learning in order to minimize the human effort required to generate annotated training data. Thus, the method effectively selects an as small as possible dataset that needs to be analyzed (and annotated) by a human operator. A key ingredient of our proposed method is to utilize a conservative estimate of confidences, which is valuable feedback data for further analysis and also assists in training data generation.
Browallia corongoana (Solanaceae) una nueva especies del Norte del Perú

Resumen Se describe e ilustra en detalle Browallia corongoana S. Leiva & Tantalean (Solanaceae), una nueva especie del norte del Peru. B. corongoana es propia de Corongo, a 5 minutos de la ciudad de Corongo, ruta Corongo-La Pampa, 8°34'46,7” S y 77°54'07,1” O, alrededor de los 3090 m de elevacion, prov. Corongo, dpto. Ancash, Peru; se caracteriza principalmente por la disposicion de las flores en racimos, el indumento de sus organos florales, estilo incluso, corola 42-42,5 mm (entre el lobulo mayor y los dos lobulos inferiores) y 35-35,5 mm (entre los dos lobulos laterales) de diametro del limbo en la antesis, capsula obconica erecta, rodeada por una cobertura de pelos eglandulares transparentes rigidos la ½ distal, 6-7 mm de largo por 5-5,2 mm de diametro. Se incluyen datos sobre su distribucion geografica y ecologia, fenologia, estado actual y sus relaciones con otras especies afines. Palabras clave: Browallia , especie nueva, Solanaceae, norte del Peru. Abstract Browallia corongoana S. Leiva & Tantalean (Solanaceae), a new species from Northern Peru, is described and illustrated in detail. B. corongoana is found about five minutes from the city of Corongo, along the Corongo-La Pampa route, at 8°34'46.7” S y 77°54'07.1” W, approximately at 3090 m of altitude, Corongo Province, Ancash Department, Peru. It is characterized principally by the flowers in raceme, the indument of its floral organs, included style, corolla 42-42.5 mm (between the major lobe and two inferior lobes) and 35-35.5 mm (between the two lateral lobes) of limb diameter at anthesis, erect obconical capsule, surrounded by a covering of rigid transparent hairs 6-7 mm of length and 5-5.2 mm of diameter. Data regarding geographic distribution, ecology, phenology, current status and similarities with other species are also discussed. Keywords: Browallia , sp. nov., Solanaceae, Northern Peru.
Expression of Epidermal Growth Factor Receptor in Papillary Thyroid Carcinoma and Its Relationship with Epithelial-Mesenchymal Transition

Objective:To investigate the expression of epidermal growth factor receptor(EGFR) in papillary thyroid carcinoma(PTC) and its relationship with epithelial-mesenchymal transition(EMT). Methods:The expression of EGFR,E-cadherin and vimentin in tumor and tumor-adjacent normal tissues from 44 patients with PTC were detected by immunohistochemistry(EnVision). The relationships of these three proteins with pathological parameters of PTC,as well as the correlation among EGFR,E-cadherin and vimentin were analyzed.Results: The expression positive rate of EGFR,E-cadherin and vimentin in tumor tissues were 68.2 %(30/44),79.5 %(35/44) and 63.6 %(28/44),while those in tumor-adjacent normal tissues were 6.8 %(3/44),4.5 %(2/44) and 9.1 %(4/44),and the differences were significant(χ2=35.35,P=0.00;χ2=50.78,P=0.00;χ2=28.59,P=0.00). EGFR was correlated negatively with E-cadherin(r=-0.306,P=0.043),but positively with vimentin(r=0.595,P=0.000). The differences in the expression of EGFR,E-cadherin and vimentin between PTC with lymph node metastasis and PTC without lymph node metastasis were significant(χ2=7.79,5.81 and 4.32 respectively,all P0.05). Conclusions: In PTC,the high expression of EGFR was accompanied by down-regulated E-cadherin and up-regulated vimentin,which may be related to EMT and lymph node metastasis.
HIGHLY COMMERCIAL FISHERIES TAWAR FISH: MOLECULAR ANALYSIS DNA MITOCHONDRIAL COI GENE SEQUENCE AND PROXIMATE ANALYSIS FROM MALACCA STRAIT, RIAU

Tawar fish is one of fish that live at the Coast of Malacca strait, Riau. Even though they live at sea but the local community has mentioned it as “tawar” fish, which means freshwater fish. Tawar fish is not found in the other place. The most interesting thing of this fish is their dried swim bladder that have an expensive price can reach as much as IDR 15 000 000 (± USD 1 200) per kg. The local community usually sell them directly to Singapore. The myth has found that this swim bladder is useful for health and could recover diseases although the actual benefit for health has not been well explored. The aim of this research was to investigate molecular approach with PCR amplification COI gene (Cytochrome Oxidase subunit I) and by means proximate analysis on the content muscle and swim bladder. The result showed that tawar fish (FBR_BCL with accession number LC064301) have 92 % sequence similarity with Boesemania microlepsis . While through the proximate analysis, it was found that this species had high protein mainly in swim bladder as much as 36.21 %. Boesemania microlepsis (Bleeker, 1858) have an economic value.
Positive degree-day factors for ablation on the Greenland ice sheet studied by energy-balance modelling

Abstract Ice ablation is related to air temperature by the positive degree-day factor. Variations of the positive degree-day factor in West Greenland are studied using an energy-balance model to simulate ablation under different conditions. Degree-day factors for simulated and measured ice ablation at Nordbogletscher and Qamanârssûp sermia agree well with values around 8 mm d−1 °C−1. Degree-day factors for snow are less than half those for ice. Energy-balance modelling shows that degree-day factors vary with summer mean temperature, surface albedo and turbulence but there is only evidence of large positive degree-day factors at lower temperatures and with low albedo (0.3). The greatest effect of albedo variations (0.3–0.7) is at lower temperatures while variations in turbulence have greater effect at higher temperatures. Current models may underestimate runoff from the Greenland ice sheet by several tenths because they use a degree-day factor for melting ice that is too small for the colder parts of the ice sheet, i.e. the upper ablation area and the northerly margin.
Editorial: Interleukin-6: The Endocrine Cytokine

The field of cytokines has expanded tremendously over the last 2 decades. Initially, they were thought to be products of the immune system alone that had immune and hematological functions only. Yet, it has become increasingly apparent that cytokines participate in a neuroendocrine and immune system network, in which both the nervous and endocrine systems participate. Interleukin-6 (IL-6) and, to a lesser extent, tumor necrosis factor a have been shown to have endocrine as well as autocrine and paracrine roles. IL-6, in particular, has drawn much attention in the endocrine field for it is the most “endocrine” of all cytokines. The current issue hosts two articles that further expand our knowledge in the endocrine significance of IL-6.
Kinetics of Hemoglobin and Albumin Adducts in Rabbits Subchronically Exposed to Benzo[a]pyrene

Abstract Kinetics of Hemoglobin and Albumin Adducts in Rabbits Sobchronically Exposed to Benzo[a]pyrene. Viau, C. , and Carrier, G. (1995). Fundam, Appl. Toxicol. 24, 140-144. Benzo[a]pyrene (BaP) can form adducts with proteins after activation to a diolepoxide. Benzo[a]pyrene-hemoglobin and BaP-albumin adducts were measure in rabbits exposed to 0.5 or 5 μmol · kg -1 · week -1 for a total of 11 weeks (last injection on Day 75). Each dose group of nine rabbits was divided into three equal subgroups. For each dose, one subgroup received a single weekly injection (Mondays), the second had two equal weekly injections (Mondays and Thursdays), and the third had five weekly injections (Mondays through Fridays). Blood was collected prior to injection on Days 0, 7, 14, 21, 28, 35, 42, 49, 56, 77, 78, 80, 84, 92, 108, and 140 for adducts determinations, with Day 0 being a Monday. The measured concentration of hemoglobin adducts was independent of the frequency of administration for a given total weekly dose giving support to its value as a "biointegrator. " In addition, animals injected with 0.5 and 5 μmol BaP · kg -1 · week 1 had respective mean adduct concentrations of 0.3 and 3 pmol/g hemoglobin. The blood concentration of albumin adducts was related to the frequency of injection with the animals receiving one, two and five injections/week having the lowest, intermediate, and highest adduct concentrations, respectively. Animals injected wilh 0.5 and 5 μmol BaP · kg -1 · week -1 had respective mean adduct concentrations of 5 and 20 pmol/g which are 17 and 7 times higher than their corresponding hemoglobin adducts' values. The corresponding albumin adducts' half-lives calculated from the day of cessation of exposure were 5.8 and 9.6 days, compared with a reported 5.7 days for the half-life of the intact protein. Comparison of the pattern of hemoglobin adduct formation and removal with currently proposed kinetic adduct model could only be performed for the 5 μmol BaP · kg 1 · week 1 dose as hemoglobin adduct concentrations fell below detection limit after cessation of exposure at the lower dose. The higher dose data suggested that the model reasonably describe the overall profile observed. However, this limited comparison also suggested that, for hydrophobic substances such as BaP capable of enzymatic induction, introduction of both an induction function and consideration of the kinetics of the parent compound itself in the organism would probably improve the fit.
Regulation of Apoptosis Induced by the Retinoid N-(4-Hydroxyphenyl) Retinamide and Effect of Deregulated bcl-2

The cancer chemopreventive retinoid N-(4-hydroxyphenyl)-all-trans retinamide (HPR) was recently shown by us to have antiproliferative and apoptotic effects on human leukemic cell lines, including those unresponsive to all-trans retinoic acid (ATRA). We have now characterized further the process of HPR-induced cell death. We report that inhibitors of RNA transcription and of protein synthesis, activators of protein kinase C (PKC), inhibitors of tyrosine kinases, Zn++, and the antioxidants acetylcysteine, ascorbic acid, alpha-tocopherol, and deferoxamine suppressed HPR-induced apoptosis. HL60 cells induced toward monocytic differentiation by 1,25 dihydroxyvitamin-D3 [1,25(OH)2D3], but not those induced toward the granulocytic differentiation by ATRA, showed reduced responses to HPR. The transport of HPR by cells with different sensitivity to the retinoid, however, was similar, even after treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which induces unresponsiveness to HPR. The expression of the apoptosis-related genes bcl-2, p53, and c-myc was examined to determine their role in HPR-triggered cell death. The levels of bcl-2 mRNA were markedly diminished by 24 hours of HPR treatment in all cell lines except in the relatively HPR-insensitive line K422. However, probably because of its long half-life, bcl-2 protein levels were either unchanged or only slightly decreased. Downregulation of p53 mRNA was also observed within 24 hours of HPR exposure in NB4 but not K422 cells, but no changes in the amount of p53 protein were found. Suppression of c-myc transcription was observed in all cells except K422. The protective role of bcl-2 on cell death by HPR was investigated in HL60 as well as 697 pre-B leukemia and Jurkat T-acute lymphocytic leukemia (T-ALL) cells constitutively expressing high levels of bcl-2 proteins due to gene transfer manipulation. Compared with control cells, the onset of apoptosis in these cells with deregulated bcl-2 production was delayed by at least 24 hours. These findings establish that cell death by HPR requires RNA transcription and protein synthesis and is regulated by the activation of PKC. Although changes in bcl-2, p53, and c-myc expression are found in cells treated with HPR, the time-course of these events suggests that HPR-triggered apoptosis is not directly controlled by these genes. Finally, while ectopic overexpression of bcl-2 does not protect cells from death by HPR, it markedly delays its onset. (ABSTRACT TRUNCATED AT 400 WORDS)
A rose is a REEZ: The two-cycles model of phonology assembly in reading English

The authors propose a model of phonological assembly that postulates a multilinear representation that segregates consonants and vowels in different planes. This representation determines the online process of assembly: Consonants and vowels are derived in 2 consecutive cycles that differ in their automaticity. The model's temporal properties resolve critical contradictions in the phonological processing literature. Its claims are further supported by a series of English-masking and Englishpriming experiments demonstrating that the contributions of consonants and vowels depend on target exposure duration and differ in their susceptibility to digit load. One methodological implication of the model is that regularity effects are not necessary evidence for assembly. This claim is supported by naming studies showing that vowel assembly requires long target durations, but short target durations permit consonant assembly despite null evidence for vowels.
“Being There”: Proximity, Organization, and Culture in the Development and Adoption of Advanced Manufacturing Technologies

AbstractRecent work on innovation and technology implementation suggests the importance of closeness between collaborating parties for the successful development and adoption of new technologies. "Closeness" is used here both in the literal sense, as allowing more frequent, effective, often unplanned interaction, and more broadly, to encompass common language, modes of communication, customs, conventions, and social norms. Such relationships are said to be particularly important in the case of production process innovations. These theoretical ideas are subjected to empirical scrutiny through a postal survey and set of interviews with users of advanced manufacturing technologies in Southern Ontario. Given the premise that intensive interaction and collaboration between users and producers of advanced process technologies is necessary for successful technology implementation to occur, then the chronically underdeveloped state of the Ontario advanced machinery sector ought to create major difficulties for ma.
Relationship between genetic polymorphism of N-acetyltransferase and early-onset Parkinson disease

Objective To investigate the relationship between the slow acetylator genotype induced by the genetic polymorphism of N acetyltransferase 2 (NAT2) gene and the early onset Parkinson disease. Methods Polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) method was used and three mutant alleles M1, M2 and M3 of NAT2 were studied in 126 patients with idiopathic early onset Parkinson disease and 122 age matched randomly selected controls. Results The frequencies of alleles M1, M2 and M3 of NAT2 in patients were 8 7%,26 6% and 13 1%,respectively,however,there were 2 9%,19 7% and 14 8% in controls, respectively The difference in frequency of allele M1 was statistically significant( P =0 005) The frequency of slow acetylator genotype was higher in patients (23 0%) than in controls (10 7%), showing an OR of 2 507( P =0 009). Conclusion Our study suggests that the slow acetylator genotype of N acetyltransferase 2 might be associated with the occurrence of the idiopathic early onset Parkinson′s disease
Biology, Ecology, and Management of Nonnative Ambrosia Beetles (Coleoptera: Curculionidae: Scolytinae) in Ornamental Plant Nurseries

Floriculture and Nursery Research Initiative (USDA-FNRI); Horticultural Research Institute (HRI); USDA-ARS National Program 304-Crop Protection and Quarantine [3607-22000-012-00D]; American Nursery and Landscape Association; USDA-Animal and Plant Health Inspection Service; Virginia Nursery and Landscape Association
Regular ArticleEvolution of Euphilotes (Lepidoptera: Lycaenidae) by seasonal and host shifts

The lycaenid butterfly genus Euphilotes, consisting of five species and several dozen subspecies, is confined to western North America. Each subspecies utilizes one or a few species of Eriogonum (Polygonaceae) as larval hosts; larvae feed entirely on pollen and developing seeds. Euphilotes populations are (with few exceptions) univoltine and fly in synchrony with the initial (c. 2 weeks) annual flowering periods of their hosts. Euphilotes evolution coincides with shifts to new hosts, frequently with different bloom periods. Often both inter- and intraspecific populations occur in sympatry. Although interspecific populations may fly in synchrony and utilize the same hosts, sympatric intraspecific populations use different hosts and generally fly allochronically. Analyses of Euphilotes populations using biochemical, morphological, and life history characters, do not support either coevolution or sequential evolution with Eriogonum but are more consistent with opportunistic adaptation to new hosts having different bloom periods.
Hypercompetition: Managing the Dynamics of Strategic Maneuvering

Neue Technologien, globale Wettbewerber und flexible Produktionseinrichtungen fuhren zur Aufheizung der Markte uberall auf der Welt. Mit dem Wort „Hyperwettbewerb“ wird dieses Umfeld des auserst haufigen und intensiven Wandels bezeichnet, das die Vorteile etablierter Anbieter erodiert. Generische Wettbewerbsstrategien wie Kostenfuhrerschaft, Differenzierung und Fokussierung erweisen sich als instabil — sind angestammte Wettbewerbsvorteile noch nachhaltig? Welche Wettbewerbsstrategien sind in einem solchen Umfeld noch erfolgreich?
Temporal dynamics of functional networks in long-term infant scalp EEG

Human functional connectivity networks are modulated on time scales ranging from milliseconds to days. Rapid changes in connectivity over short time scales are a feature of healthy cognitive function, and variability over long time scales can impact the likelihood of seizure occurrence. However, relatively little is known about modulation of healthy functional networks over long time scales. To address this, we analyzed functional connectivity networks calculated from long-term EEG recordings from 19 healthy infants. Networks were subject-specific, as inter-subject correlations between weighted adjacency matrices were low. However, within individual subjects, both sleep and wake networks were stable over time, with stronger functional connectivity during sleep than wakefulness. This enabled automatic separation of wakefulness and sleep states via principle components analysis of the functional network time series, with median classification accuracy of 91%. Lastly, we found that network strength, degree, clustering coefficient, and path length significantly varied with time of day, when measured in both wakefulness and sleep. Together, these results suggest that modulation of healthy functional networks occurs over long timescales and is robust and repeatable. Accounting for such temporal periodicities may improve the physiological interpretation and use of functional connectivity analysis to investigate brain function in health and disease.
Differential dopaminergic modulation of spontaneous cortico–subthalamic activity in Parkinson’s disease

Pathological oscillations including elevated beta activity in the subthalamic nucleus (STN) and between STN and cortical areas are a hallmark of neural activity in Parkinson’s disease (PD). Oscillations also play an important role in normal physiological processes and serve distinct functional roles at different points in time. We characterised the effect of dopaminergic medication on oscillatory whole-brain networks in PD in a time-resolved manner by employing a hidden Markov model on combined STN local field potentials and magnetoencephalography (MEG) recordings from 17 PD patients. Dopaminergic medication led to communication within the medial and orbitofrontal cortex in the delta/theta frequency range. This is in line with deteriorated frontal executive functioning as a side effect of dopamine treatment in Parkinson’s disease. In addition, dopamine caused the beta band activity to switch from an STN-mediated motor network to a frontoparietal-mediated one. In contrast, dopamine did not modify locally-originating STN oscillations in PD. STN–STN synchrony emerged both on and off medication. By providing electrophysiological evidence for the differential effects of dopaminergic medication on the discovered networks, our findings open further avenues for electrical and pharmacological interventions in PD.
Germline DNA replication shapes the recombination landscape in mammals

Genetic recombination generates novel trait combinations and understanding how recombination is distributed across the genome is key to modern genetics. The PRDM9 protein defines recombination hotspots, however megabase-scale recombination patterning is independent of PRDM9. The single round of DNA replication, which precedes recombination in meiosis, may establish these patterns, therefore we devised a novel approach to study meiotic replication that includes robust and sensitive mapping of replication origins. We find that meiotic DNA replication is distinct; reduced origin firing slows replication in meiosis and a distinctive replication pattern in human males underlies the sub-telomeric increase in recombination. We detected a robust correlation between replication and both contemporary and ancestral recombination and found that replication origin density coupled with chromosome size determines the recombination potential of individual chromosomes. Our findings and methods have far-reaching implications for understanding the mechanisms underlying DNA replication, genetic recombination, and the landscape of mammalian germline variation.