Miracle-dz/UniFAR-FTUs huggingface dataset:
Poor sleep quality predicts deficient emotion information processing over time in early adolescence.

STUDY OBJECTIVES There is deepening understanding of the effects of sleep on emotional information processing. Emotion information processing is a key aspect of social competence, which undergoes important maturational and developmental changes in adolescence; however, most research in this area has focused on adults. Our aim was to test the links between sleep and emotion information processing during early adolescence. DESIGN Sleep and facial information processing were assessed objectively during 3 assessment waves, separated by 1-year lags. SETTING Data were obtained in natural environments-sleep was assessed in home settings, and facial information processing was assessed at school. PARTICIPANTS 94 healthy children (53 girls, 41 boys), aged 10 years at Time 1. INTERVENTIONS N/A. MEASUREMENTS AND RESULTS Facial information processing was tested under neutral (gender identification) and emotional (emotional expression identification) conditions. Sleep was assessed in home settings using actigraphy for 7 nights at each assessment wave. Waking > 5 min was considered a night awakening. Using multilevel modeling, elevated night awakenings and decreased sleep efficiency significantly predicted poor performance only in the emotional information processing condition (e.g., b = -1.79, SD = 0.52, confidence interval: lower boundary = -2.82, upper boundary = -0.076, t(416.94) = -3.42, P = 0.001). CONCLUSIONS Poor sleep quality is associated with compromised emotional information processing during early adolescence, a sensitive period in socio-emotional development.
Service Failure in the Hospital Industry: The Indonesian Experience

The main objective of the study is to examine dimensions of service failures in the hospital industry. The primary study was conducted in four cities in Bengkulu province, Southwest Sumatra, Indonesia. Selfadministered questionnaires were distributed in the survey to collect the dataset. The number of questionnaires distributed in the survey was 300 and 300 questionnaires were returned and analyzed. Factor analysis and cluster analysis were employed to the dataset. The result of the analysis reveals that service failure constructs can be categorized into six underlying dimensions such as Medical reliability errors, Physical evidences errors, Poor information, Medical treatment errors, Costly service, and Complaint handling failures. The study also indicates that hospital patients can be clustered into three segments, namely demanding segment, complainer segment, and salient patient segment. Service failure dimensions and the clusters found can be used by hospitals in Indonesia to improve their service process and delivery. Publication Details This conference paper was originally published as Alfansi, L. and Atmaja, F. T. , Service Failure in the Hospital Industry: The Indonesian Experience, Partnerships, Proof and Practice International Nonprofit and Social Marketing Conference 2008, University of Wollongong, 15-16 July 2008. This conference paper is available at Research Online: http://ro.uow. edu.au/insm08/16 Service Failure in the Hospital Industry: The Indonesian Experience Lizar Alfansi and Ferry Tema Atmaja, University of Bengkulu, Indonesia Abstract The main objective of the study is to examine dimensions of service failures in the hospital industry. The primary study was conducted in four cities in Bengkulu province, Southwest Sumatra, Indonesia. Self-administered questionnaires were distributed in the survey to collect the dataset. The number of questionnaires distributed in the survey was 300 and 300 questionnaires were returned and analyzed.The main objective of the study is to examine dimensions of service failures in the hospital industry. The primary study was conducted in four cities in Bengkulu province, Southwest Sumatra, Indonesia. Self-administered questionnaires were distributed in the survey to collect the dataset. The number of questionnaires distributed in the survey was 300 and 300 questionnaires were returned and analyzed. Factor analysis and cluster analysis were employed to the dataset. The result of the analysis reveals that service failure constructs can be categorized into six underlying dimensions such as Medical reliability errors, Physical evidences errors, Poor information, Medical treatment errors, Costly service, and Complaint handling failures. The study also indicates that hospital patients can be clustered into three segments, namely demanding segment, complainer segment, and salient patient segment. Service failure dimensions and the clusters found can be used by hospitals in Indonesia to improve their service process and delivery.
INSTRUCTIONAL DESIGN AND ASSESSMENT Assessment of Streams of Knowledge, Skill, and Attitude Development Across the Doctor of Pharmacy Curriculum

Objective. To continue efforts of quality assurance following a 5-year curricular mapping and course peer review process, 18 topics (‘‘streams’’) of knowledge, skills, and attitudes were assessed across the doctor of pharmacy (PharmD) curriculum. Design. The curriculum committee merged the 18 topics into 9 streams. Nine ad hoc committees (‘‘stream teams’’) of faculty members and preceptors evaluated the content, integration, and assessment for their assigned streams across the 4 professional years. Committees used a reporting tool and curriculum database to complete their reviews. Assessment. After each team presented their findings and recommendations at a faculty retreat, the 45 faculty members were asked to list their top priorities for curriculum improvement. The 5 top priorities identified were: redefinition and clarification of program outcomes; improved coordination of streams across the curriculum; consistent repetition and assessment of math skills throughout the curriculum; focused nonprescription and self-care teaching into an individual course; and improved development of problem solving. Conclusions. This comprehensive assessment enabled the college to identify areas for curriculum improvement that were not readily apparent to the faculty from prior reviews of individual courses.
University-Based Continuing Education for Pharmacists

University-based continuing education (CE) fulfills an important role to support the professional development of pharmacists, advance the practice of pharmacy, and contribute to societal needs for research and healthcare services. Opportunities for pharmacists to engage in new models of patient care are numerous worldwide, particularly as pharmacists’ scope of practice has expanded. Approaches to CE have changed to address the changing needs of pharmacists and now include a variety of approaches to support development of knowledge and skills. There is emphasis on the learning process as well as the knowledge, with the introduction of the concept of continuing professional development (CPD). As institutions of research and education, universities are uniquely positioned to bridge the gap between academic and practice environments, providing opportunities for translation of knowledge to practice. The Faculty of Pharmacy and Pharmaceutical Sciences at the University of Alberta is a provider of CE in Alberta, Canada, where an expanded scope of pharmacy practice includes prescribing, administering injections, accessing electronic patient records, and ordering laboratory tests. In this paper, the Faculty offers views about future directions for CE, including the integration of CE with core faculty activities, expanding the audience for CE, areas of focus for learning, and partnerships. Finally, we hope to ignite dialogue with others in the profession about the role and function of university-based CE.
Using Facebook to Facilitate Course-Related Discussion Between Students and Faculty Members

Objectives. To use Facebook to facilitate online discussion of the content of a Comprehensive Disease Management course and to evaluate student use and perceptions of this exercise. Design. A Facebook page was created and coordinators encouraged students to “like” the page and to post and view study tips, links, or questions. At the end of the course, students’ use and perceptions were evaluated using an anonymous survey tool. Assessment. At the end of week 1, there were 81 followers, 5 wall posts, and 474 visits to the course Facebook page. At peak use, the page had 117 followers, 18 wall posts, and 1,326 visits. One hundred nineteen students (97% of the class) completed the survey tool. Twenty-six percent of students contributed posts compared to 11% who posted on the course discussion board on Blackboard. Students were more likely to post and be exposed to posts on Facebook than on Blackboard. Students found Facebook helpful and 57% said they would miss Facebook if use was not continued in subsequent courses. Conclusions. Students in a Comprehensive Disease Management course found the addition of a Facebook page a valuable study tool and thought most posts added to their learning.
AACP Strategy for Addressing the Professional Development Needs of Department Chairs

Objectives. Characterize the skills and abilities required for department chairs, identify development needs, and then create AACP professional development programs for chairs. Methods. A 30-question electronic survey was sent to AACP member department chairs related to aspects of chairing an academic department. Results. The survey identified development needs in the leadership, management, and personal abilities required for effective performance as department chair. The information was used to prioritize topics for subsequent AACP development programs. Subsequent programs conducted at AACP Interim and Annual Meetings were well attended and generally received favorable reviews from participants. A list of development resources was placed on the AACP website. Conclusions. This ongoing initiative is part of an AACP strategy to identify and address the professional development needs of department chairs. Survey results may also inform faculty members and other academic leaders about the roles and responsibilities of department chairs.
The cost of osteoporotic fractures in the UK: projections for 2000–2020

SUMMARY The prevalence of osteoporosis increases with age. The over-50-year-old population is expected to grow by 10% and 25% by 2010 and 2020, respectively. There are already 3 million UK residents with osteoporosis and the public health impact of osteoporosis will increase substantially over the next 20 years. A Markov model of the natural history of osteoporosis was used to predict fracture numbers and corresponding costs for the UK population aged 50-99 from 2000 to 2020. The model predicts 190,000 osteoporosis-related fractures at a cost of £1.8 billion in 2000. By 2020, annual osteoporotic fractures will increase by 21% to 230,000 per year, with costs growing by 20% to over £2.1 billion per year. Cumulative totals for 2000-2010 were 2.2 million fractures and £20.3 billion. Osteoporotic fractures will have substantial and increasing impacts on UK health services unless highly effective preventative interventions achieve widespread use.
Managing relapsing–remitting multiple sclerosis following first drug failure

SUMMARY IFN-β and glatiramer acetate are the usual first-line treatments for cases of relapsing–remitting multiple sclerosis. As both of these agents are only partially effective in controlling disease activity, ‘breakthrough’ disease is common. Deciding how much breakthrough constitutes a treatment failure necessitating a switch in therapy is now a common problem that most clinicians will encounter in practice. In this article we will discuss the approach to deciding when treatment failure occurs and the strategies that can be used to tackle this problem.
An Advanced Objective Structured Clinical Examination Using Patient Simulators to Evaluate Pharmacy Students’ Skills in Physical Assessment

Objective. To implement an advanced objective structured clinical examination (OSCE) in the curriculum and to evaluate Japanese pharmacy students’ skills in physical assessment such as measuring pulse and blood pressure, and assessing heart, lung, and intestinal sounds. Design. An advanced OSCE was implemented in a hospital pharmacy seminar as a compulsory subject. We programmed patient simulators with 21 different patient cases in which normal and abnormal physiological conditions were produced. The virtual patients were then used to evaluate the physical assessment skills of fifth-year pharmacy students. Assessment. Significant differences were observed between the average of all the detailed evaluations and the mean results for the following skills: pulse measurement, blood pressure measurement, deflating the cuff at a rate of 2-3 mmHg/sec, listening to heart sounds, and listening to lung sounds. Conclusion. Administering an advanced OSCE using virtual patients was an effective way of assessing pharmacy students’ skills in a realistic setting. Several areas in which pharmacy students require further training were identified.
Evaluation of NHMRC data on the funding of dementia research in Australia

The aim of this report is to provide the evidence base for evaluating the level of expenditure by the National Health and Medical Research Council (NHMRC) on research funding (including research, people support and infrastructure) related to dementia, in comparison to research funding for other areas of chronic disease. The report was commissioned by Alzheimer’s Australia to support a submission to the McKeon Review of Health and Medical Research in Australia in March, 2012.
Sleep Quality Among Pharmacy Students

Objective. To determine the quality of sleep among pharmacy students in the didactic portion of the curriculum at one school of pharmacy. Methods. The study consisted of an anonymous, voluntary survey that included the Pittsburgh Sleep Quality Index (PSQI), a self-rated instrument that measures sleep habits for a month. Results. The survey was completed by 253 students. Students in the lower grade point average (GPA) category had higher scores on 2 of 7 components of the PSQI and on the global score. Poor sleep quality, indicated by a global PSQI score of greater than 5, was reported by 140 students. The rate of poor sleeping was higher among students in the lower GPA category. Conclusion. Poor sleep quality was pervasive among surveyed pharmacy students in the didactic portion of the pharmacy school curriculum, especially among those with lower GPAs.
The New Injury Severity Score: Availability in E valuation of Severity of Polytrauma Patients with Orthopaedic Injuries

The New Injury Severity Score: Availability in E valuation of Severity of Polytrauma Patients with Orthopaedic Injuries Significant number of patients with multiple injuries are registered every year in Latvia. In 2009 during seven months 298 patients with multiple trauma are registered. In the most of the cases cause of multiple injuries are road accidents (Health Statistics and Medical Technologies State Agency, Latvia). Using of the simple modification of the Injury Severity Score (ISS) - the New Injury Severity Score (NISS) - makes possibility to better assess the patients with multiple injuries, particularly patients with orthopaedic injuries, predict resources for treatment, the outcome and functional results.
Research, Perspectives, and Recommendations on Implementing the Flipped Classroom

Flipped or inverted classrooms have become increasingly popular, and sometimes controversial, within higher education. Many educators have touted the potential benefits of this model and initial research regarding implementation has been primarily positive. The rationale behind the flipped classroom methodology is to increase student engagement with content, increase and improve faculty contact time with students, and enhance learning. This paper presents a summary of primary literature regarding flipped classrooms, discusses concerns and unanswered questions from both a student and faculty member perspective, and offers recommendations regarding implementation.
Serum Leptin Levels in Patients with Idiopathic Sudden Sensorineural Hearing Loss

MATERIALS and METHODS: The study was performed between March 2010 and December 2011 in the otorhinolaryngology department of a tertiary referral center. A total of 33 idiopathic sudden sensorineural hearing loss patients and 38 healthy controls were compared in terms of demographic features (age, gender, and body mass index) and serum leptin levels. Serum leptin levels were assessed by enzyme-linked immunosorbent assay method, and statistical analysis was conducted via Mann-Whitney Uand student t-tests.
Validation of the BacT/ALERT® 3D System for Rapid Sterility Testing of Biopharmaceutical Samples

The BacT/ALERT® 3D system was validated to determine the sterility of different types of biopharmaceutical samples such as water for injection, unprocessed bulk, and finished bulk. The installation, operation, and performance qualification were completed and verified under good manufacturing practices. During the installation and operation validation stages, the functionality and security of the system and software were completed and verified. For the performance qualification, 11 microorganisms were evaluated, six compendial (Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Aspergillus niger, Clostridium sporogenes), one representing the number one microbial species in sterile product recalls (Burkholderia cepacia), and four environmental isolates (Kocuria rhizophila, Staphylococcus haemolyticus, Methylobacterium radiotolerans, and Penicillium spp.). Nine of the microorganisms were spiked into three different types of biopharmaceutical samples by three different analysts on different days to ascertain the equivalence, ruggedness, sensitivity, time of detection, and repeatability. In all samples, the BacT/ALERT® exhibited equivalent or better detection than the standard test. With the exception of M. radiotolerans, all 11 microorganisms were detected within 2.5 days using the BacT/ALERT® system and the standard test. The detection times for M. radiotolerans in the three sample types averaged 5.77 days. The minimum detectable level of cells for all the microorganisms tested was found to be within 1 to 2 CFU. The system optimized sterility testing by the simultaneous on-line, non-destructive incubation and detection of microbial growth.
Sustained Delivery of Amphotericin B and Vancomycin Hydrochloride by an Injectable Thermogelling Tri-Block Copolymer

Because traditional drug delivery poses many disadvantages such as poor compliance of patients and a drug plasma level variation, novel drug delivery systems containing controlled release drug vehicles become attractive. In this study, a kind of tri-block copolymer consisting of polycaprolactone (PCL) and poly(ethylene glycol) (PEG), PCL-PEG-PCL, were synthesized by a rapid microwave-assisted and a conventional synthesis method to form an in situ gelling system that provides a controlled release of drugs over a long period of time. Copolymer characterization was performed using a gel permeation chromatography, the 1H-NMR, and a phase transition behavior evaluation. Vancomycin hydrochloride and amphotericin B were used as drug models here. This study confirmed that the synthesis of the copolymer using microwave irradiation was the most effective method to prepare this smart copolymer. Results also demonstrated the better performance of the microwave-synthesized copolymer regarding its phase behavior. It was shown that gelatin temperatures were also affected by the hydrophilicity of the drug model, the copolymer concentration, and the media. It was indicated that the hydrogels could sustain the delivery of model drugs for about 17 to 20 days. As the drugs used in this study were both large molecules and the main release mechanism was copolymer bulk erosion rather than simple diffusion, the effect of drug and copolymer concentration on the drug release profile was not so significant. LAY ABSTRACT: Different studies have been carried out to improve drug delivery systems. Smart drug vehicles such as thermoresponsive and in situ forming hydrogels made of tri-block copolymers are promising systems in this field. Thermoresponsive hydrogels can release loaded molecules in response to the changing temperature. In situ forming hydrogels are the kind of thermoresponsive materials that are injectable fluid (sol) at room temperature and gel at body temperature. Pharmaceuticals release gradually from the gel over long periods of time. Here we investigated the in situ forming hydrogel based on poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone) as a drug delivery system. Vancomycin hydrochloride and amphotericin B were used in this study as a model. The results indicated that this system can control release pattern of drug perfectly for approximately 20 days.
Comparison of Different Fungal Agar for the Environmental Monitoring of Pharmaceutical-Grade Cleanrooms

In relation to a growth in reported incidents of fungal contamination of pharmaceutical products, there has been a developing interest by U.S. and U.K. regulators concerning the risk of fungi. This paper describes a study undertaken to examine the suitability of different commercially available mycological agars for the environmental monitoring of pharmaceutical-grade cleanrooms. Five agars were evaluated in relation to the detection of both numbers and different species of fungi (yeasts and moulds). The objective was to determine if one mycological medium is more suitable than another. Data was collected using different sampling techniques (settle plates, active air samples, and contact plates) from different locations within representative cleanrooms. Samples were taken over a 3 month time period. The study results indicated that fungi are not distributed evenly across cleanrooms and that that the prevalence of fungi partly relates to the room design and operation. In relation to the different agar types, the study indicated that Sabouraud dextrose agar was the most effective at detecting the widest number of different types of isolates, and that Sabouraud dextrose agar and malt extract agar were the most efficient in terms of the numbers of recovered isolates. Other media, notably potato dextrose agar, was relatively less effective. LAY ABSTRACT: There has been an increased regulatory concern about the presence of fungi in cleanrooms. Some environmental monitoring regimes are not especially orientated towards the examination of fungi, and it may be that special agars are required. Given the choice of different agars available, this paper outlines a case study where different fungal agars were evaluated. The study showed that Sabouraud dextrose agar was the optimal agar.
Anti-TNF-α therapy in ankylosing spondylitis

Ankylosing spondylitis (AS) is a frequent disease leading to functional impairment and socioeconomic burden. Anti-TNF-α therapy has brought new perspectives in this condition. Two agents are currently used in the treatment of AS and spondyloarthropathies – infliximab (a chimeric monoclonal antibody) and etanercept (a soluble p75 TNF-receptor). Open-label studies have shown the feasibility and efficacy of these drugs. Controlled studies have confirmed the latter, at least in the short-term (1 year). Improvement in several clinical parameters, function, quality of life, biological parameters and magentic resonance imaging acute inflammation, have been observed. Due to these favourable results, anti-TNF have been approved for the treatment of AS. However, there are some safety concerns, essentially involving infection. Consensus guidelines for the use of anti-TNF in AS are available and assessment is based on validated tools. However, some questions still remain unanswered, such as the long-term efficacy and safety of anti-TNF, the possibility of structural benefit and the cost-effectiveness. Despite these concerns, Anti-TNF represents a major therapeutic advancement in the treatment of AS.