Miracle-dz/UniFAR-FTUs huggingface dataset:
Longitudinal Viral Dynamics in Semen During Early HIV Infection

Background Multiple viruses coinfect the male genital tract, influencing each other’s replication and perhaps affecting human immunodeficiency virus (HIV) pathogenesis and disease progression. Methods This study included 453 longitudinal seminal samples from 195 HIV-infected men from the San Diego Primary Infection Resource Consortium and 67 seminal samples from HIV-negative healthy controls. Seminal HIV RNA and DNA from 7 human herpesviruses (HHVs) were measured by real-time polymerase chain reaction. Longitudinal shedding rates were determined by Kaplan-Meier survival analysis. Predictors of viral shedding were determined using backwards selection in a multivariable generalized estimating equation model. Results HIV-infected participants presented significantly increased rates of seminal HHV shedding compared with HIV-uninfected controls. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) were the most commonly detected HHV in semen of HIV-infected participants. Persistent shedding was more common for CMV and EBV when compared to other HHVs. With exception of HHV-7, HHV shedding was not significantly influenced by HIV RNA levels, CD4+ cell counts, or antiretroviral therapy. Presence of CMV, EBV, and herpes simplex virus (HSV) were independent predictors of genital HIV RNA shedding after adjusting for plasma HIV RNA and longitudinal measurements. Conclusions Seminal replication of multiple HHVs is common in our HIV primary infection cohort. Genital replication of CMV and EBV was the most common and was significantly associated with seminal HIV RNA shedding. Prevalence of HSV shedding was lower and mostly intermittent, but its association with seminal HIV RNA was the strongest. Understanding the complex viral milieu in semen is important for HIV transmission but might also play a role in HIV pathogenesis and disease progression.
Process management tasks and barriers: functional to processes approach

Purpose – Migration from the traditional management model to the BPM (business process management) approach results in improved process performance. In order to promote BPM, it is necessary to have an organizational approach that defines the necessary tasks of the processes' project, day‐to‐day execution, and learning‐related tasks. In this aspect, there are difficulties and barriers to be confronted in a different way through organization. The purpose of this paper is to analyze the importance attributed to the tasks necessary for process management considering the way the management of these tasks and barriers found in order to change from functional management to process oriented management.Design/methodology/approach – A case study was developed on two companies from the services sector. In‐depth interviews with managers from the companies studied were conducted.Findings – It was identified that these companies found themselves at different levels of transition from the functional management process t.
Hepatitis C Infection and the Risk of Non-Liver-Related Morbidity and Mortality in HIV-Infected Persons in the Swiss HIV Cohort Study

Background Hepatitis C virus (HCV) infection has been associated with increased non-liver-related morbidity and mortality. However, studies have yielded inconsistent results. Methods The incidence of clinical events in human immunodeficiency virus (HIV)–infected HCV-seropositive and incidence density–matched HCV-seronegative participants of the Swiss HIV Cohort Study from August 1994 to December 2014 was studied. We compared (1) HCV-seropositive with HCV-seronegative participants and (2) HCV-viremic with successfully treated nonviremic patients. Poisson regression was used to assess differences between these groups. Results We included 2503 HCV-seropositive participants (540 with spontaneous HCV clearance, 1294 untreated HCV RNA positive, 345 treated with sustained virologic response [SVR], 43 during treatment, and 281 treated without SVR), and 2503 HCV-seronegative controls. After a mean follow-up of 8.2 years, we observed (HCV seropositive and HCV seronegative, respectively) 107 and 18 liver events, 41 and 14 kidney events, 230 and 121 osteoporosis/fractures, 82 and 94 diabetes mellitus, 114 and 129 cardiovascular events, 119 and 147 non-AIDS malignancies, 162 and 126 Centers for Disease Control and Prevention HIV category B/C events, 106 and 10 liver-related deaths, and 227 and 218 non-liver-related deaths. Compared with HCV-negative controls, HCV-seropositive participants had an increased risk of liver events (incidence rate ratio [IRR], 6.29 [95% confidence interval {CI}, 3.52–11.22]), liver-related death (IRR, 8.24 [95% CI, 3.61–18.83]), kidney events (IRR, 2.43 [95% CI, 1.11–5.33]), and osteoporosis/fracture (IRR, 1.43 [95% CI, 1.03–2.01]). Among HCV-seropositive individuals, treated participants without SVR vs those with SVR had a higher risk of liver events (IRR, 6.79 [95% CI, 2.33–19.81]), liver-related death (IRR, 3.29 [95% CI, 1.35–8.05]), and diabetes mellitus (IRR, 4.62 [95% CI, 1.53–13.96]). Similar but not statistically significant differences were found between untreated HCV RNA–positive patients and those with SVR. Conclusions While HCV exposure was associated with an increased risk of kidney disease and osteoporosis/fracture, this risk did not seem to be dependent of persistent HCV RNA. Successful HCV treatment was associated with a lower incidence of liver disease, liver-related death, and diabetes mellitus, whereas the other conditions studied were less affected.
The Influence of Blood Taking, Storage Conditions and Interfering Factors on a New Fibrin Monomer Test

Wc studied the influence of venous occlusion, sample storage and possible interfering factors on a ncw fibrin monomer test, Enzymun-Test® FM. The venous occlusion study was performed in healthy volunteers (8 males and 2 females, aged 25-40 years). A manometer cuff on the upper arm was inflated above diastolic pressure and a cubital vein punctured. Blood (2 ml void followed by 4.0 ml mixed with citrate solution at 10:1 ratio) was taken immediately after puncture and at l, 3 and 5 minutes after Inflation of the cuff. Then the pressure was released and further blood samples were taken at 5.5 and 8 min. Samples were also taken with the same occlusion scheine, but with a single puncture taken at 5 min or with no occlusion at all, but with the needle in place. Aliquots of the samples were stored 0.5,1.2,3,6.5 and 23 hours at room temperature äs whole blood. The storage of citrate plasma was studied at room temperature, 4 and -20 °C. The effects of added bilirubin, hemolysate and triglyceride were investigated with samples of healthy subjects and patients. Our results showed no relevant differences between immediate venous blood draw and different times of occlusion. Blood drawing after more than 5 minutes after setting the occlusion and also after release of the pressure should be avoided. Different storage conditions and possibly interfering factors with exception of hemolysis had no relevant effect.
Applications of QFD within a concurrent engineering environment

Companies needing to establish competitive advantage must ensure their products are brought to market quickly, with the quality features sought by potential customers. Concurrent Engineering techniques can reduce time scales, but quality issues are more difficult, as customers’ needs are not readily available to the project team throughout the design process, so design effort may focus on satisfying a functional specification, imperfectly translated from customer requirements, rather than on satisfying the real customer needs as perceived in the market. The research reported here demonstrates how a Concurrent Engineering environment and Quality Function Deployment techniques can be brought together to provide an extended design team with valuable, shared information throughout the design process.
Architecture and software solutions

The current subject gateways have evolved over time when the discipline of Internet resource discovery was in its infancy. This is reflected by the lack of well‐established, light‐weight, deployable, easy‐to‐use, standards for metadata and information retrieval. We provide an introduction to the architecture, standards and software solutions in use by subject gateways, and to the issues that must be addressed to support future subject gateways.
Methods and Techniques in Clinical Chemistry.

This medium-sized volume (417 pp) contains detailed procedures for 74 different chemical determinations. More specifically, the book details the procedures used at the Stanford Clinical Laboratory where Wolf is the director. They are arranged in encyclopedic form, alphabetically by the name of the substance; therefore, the book has no index. The test names are well set apart so that it is easy to find any specific test. One of the most valuable features of the book is the brief but complete and authoritative clinical interpretations at the end of each section. These demonstrate Wolf's proficiency in summarizing clearly and accurately important points in the interpretation of each test. Clinical pathologists, internists, and pathology residents should find these sections very useful. The procedures are written for a large and well-equipped laboratory that has access to gas chromatography, atomic absorption, autoanalyzers, and Cotlove titrators. The manual is somewhat limited in that often
Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics

Purpose: We aimed to identify novel chemotherapy responsiveness biomarkers for osteosarcoma (OS) by investigating the global protein expression profile of 12 biopsy samples from OS patients. Experimental design: Six patients were classified as good responders and six as poor responders, according to the Huvos grading system. The protein expression profiles obtained by 2‐D DIGE consisted of 2250 protein spots. Results: Among them, we identified 55 protein spots whose intensity was significantly different (Bonferroni adjusted p‐value<0.01) between the two patient groups. Mass spectrometric protein identification demonstrated that the 55 spots corresponded to 38 distinct gene products including peroxiredoxin 2 (PRDX 2). Use of a specific antibody against PRDX 2 confirmed the differential expression of PRDX 2 between good and poor responders, while PRDX 2 levels as measured by Western blotting correlated highly with their corresponding 2‐D DIGE values. The predictive value of PRDX 2 expression was further confirmed by examining an additional four OS cases using Western blotting. Conclusions and clinical relevance: These results establish PRDX 2 as a candidate for chemotherapy responsiveness marker in OS. Measuring PRDX 2 in biopsy samples before treatment may contribute to more effective management of OS.
Comparison of the Numerical and Clinical Accuracy of Four Continuous Glucose Monitors

In their comments on our assessment of the accuracy of four continuous glucose monitoring (CGM) sensors, Brauker and Matsubara (1) correctly point out that our presented studies employed hyperinsulinemic-euglycemic and hypoglycemic clamps, which tested the four devices (Guardian, DexCom 3-day sensor, Navigator, and Glucoday) close to the limits of their stated glucose range. We agree that such a test goes beyond evaluation of the devices per their …
Effects of Aralia continentalis and Angelica biserrata on Inflammatory Response in Lipopolysaccharide-Induced RAW 264.7 Macrophages and Phorbol Ester-induced Ear Edema

The roots of both Aralia continentalis and Angelica biserrata, known as /lsDokwhal/rs in Korea, have been used widely as a traditional oriental medicine to treat inflammation and thrombosis. However, the pharmacological differences between A. continentalis and A. biserrata have not been fully established. In the present study, we investigated and compared the inhibitory effects of 70% ethanolic extracts of A. continentalis (ACE) and A. biserrata (ABE) on the production of inflammatory mediators and secondary swelling from chemically induced ear edema. In RAW264.7 macrophages, both ACE and ABE significantly inhibited the release of nitric oxide, prostaglandin E2, interlukin-1beta, and tumor necrosis factor-alpha in a dose dependent manner. In addition, the swelling from TPA-induced edema in mouse ears was reduced by ACE and ABE. Overall, ACE showed stronger activities than ABE in vitro and in vivo. Our results indicate that A. continentalis roots possess stronger anti-inflammatory activity than A. Biserrata roots.
Application of glycoproteomics for the discovery of biomarkers in lung cancer

Lung cancer is the leading cause of cancer‐related deaths in the United States. Approximately 40–60% of lung cancer patients present with locally advanced or metastatic disease at the time of diagnosis. Lung cancer development and progression are a multistep process that is characterized by abnormal gene and protein expressions ultimately leading to phenotypic change. Glycoproteins have long been recognized to play fundamental roles in many physiological and pathological processes, particularly in cancer genesis and progression. In order to improve the survival rate of lung cancer patients, the discovery of early diagnostic and prognostic biomarkers is urgently needed. Herein, we reviewed the recent technological developments of glycoproteomics and published data in the field of glycoprotein biomarkers in lung cancer, and discussed their utility and limitations for the discovery of potential biomarkers in lung cancer. Although numerous papers have already acknowledged the importance of the discovery of cancer biomarkers, the systemic study of glycoproteins in lung cancer using glycoproteomic approaches is still suboptimal. Recent development in the glycoproteomics will provide new platforms for identification of potential protein biomarkers in lung cancers.
Gathering meta-data and instances from object referral lists on the web

Purpose – The purpose of this research is to automatically separate and extract meta‐data and instance information from various link pages in the web, by utilizing presentation and linkage regularities on the web.Design/methodology/approach – Research objectives have been achieved through an information extraction system called semantic partitioner that automatically organizes the content in each web page into a hierarchical structure, and an algorithm that interprets and translates these hierarchical structures into logical statements by distinguishing and representing the meta‐data and their individual data instances.Findings – Experimental results for the university domain with 12 computer science department web sites, comprising 361 individual faculty and course home pages indicate that the performance of the meta‐data and instance extraction averages 85, 88 percent F‐measure, respectively. Our METEOR system achieves this performance without any domain specific engineering requirement.Originality/valu.
The implementation of faceted classification in web site searching and browsing

Purpose – The aim of this paper is to develop and implement a multidimensional classification system in the web that can provide an alternative but convenient structure for organising and finding information content.Design/methodology/approach – A prototype system is developed following the views of Ranganathan's faceted classification, which is to provide multiple classifications of the web documents through content oriented metadata organised under different facets (orthogonal groups of categories). Findings – Based on an architectural framework this study demonstrates a prototype faceted classification system (FCS) that is integrated into a general open‐source content management system and populated with a sample collection of institutional web pages/documents.Originality/value – The study provides significant grounds for the IR community to improve interface structure for easy access, management, and retrieval of web information. In addition, the integration of content management tools with multidimens.
The impact of online store environment cues on purchase intention: Trust and perceived risk as a mediator

Purpose – The purpose of this paper is to investige whether online environment cues (web site quality and web site brand) affect customer purchase intention towards an online retailer and whether this impact is mediated by customer trust and perceived risk. The study also aimed to assess the degree of reciprocity between consumers' trust and perceived risk in the context of an online shopping environment.Design/methodology/approach – The study proposed a research framework for testing the relationships among the constructs based on the stimulus‐organism‐response framework. In addition, this study developed a non‐recursive model. After the validation of measurement scales, empirical analyses were performed using structural equation modelling.Findings – The findings confirm that web site quality and web site brand affect consumers' trust and perceived risk, and in turn, consumer purchase intention. Notably, this study finds that the web site brand is a more important cue than web site quality in influencing.
Marijuana Use Impacts Midlife Cardiovascular Events in HIV-Infected Men

Summary Long-term, heavy marijuana use was associated with increased cardiovascular events in human immunodeficiency virus (HIV)–infected men aged 40–60 independent of tobacco smoking, viral load, and other risk factors, while there was no significant association with HIV disease markers, progression to AIDS, or mortality.
Biomarker discovery in asthma and COPD by proteomic approaches

Asthma and chronic obstructive pulmonary disease (COPD) are multifactorial respiratory diseases, characterized by reversible and irreversible airway obstruction, respectively. Even if the primary causes of these diseases remain unknown, inflammation is a central feature that leads to progressive and permanent pulmonary tissue damage (airway remodeling) up to the total loss of lung function. Therefore, the elucidation of the inflammation mechanisms and the characterization of the biological pathways, involved in asthma and COPD pathogenesis, are relevant in finding new possible diagnostic/prognostic biomarkers and for the validation of new drug targets. In this context, current advances in proteomic approaches, especially those based on MS, provide new tools to facilitate the discovery‐driven studies of new biomarkers in respiratory diseases and improve the clinical reliability of the next generation of biomarkers for these diseases consisting of multiple phenotypes. This review will report an overview of the current proteomic methods applied to the discovery of candidate biomarkers for asthma and COPD, giving a special emphasis to emerging MS‐based techniques.
Effect of Surface Modification on Nano-Structured LiNi(0.5)Mn(1.5)O4 Spinel Materials.

Fine-tuning of particle size and morphology has been shown to result in differential material performance in the area of secondary lithium-ion batteries. For instance, reduction of particle size to the nanoregime typically leads to better transport of electrochemically active species by increasing the amount of reaction sites as a result of higher electrode surface area. The spinel-phase oxide LiNi0.5Mn1. 5O4 (LNMO), was prepared using a sol-gel based template synthesis to yield nanowire morphology without any additional binders or electronic conducting agents. Therefore, proper experimentation of the nanosize effect can be achieved in this study. The spinel phase LMNO is a high energy electrode material currently being explored for use in lithium-ion batteries, with a specific capacity of 146 mAh/g and high-voltage plateau at ∼4.7 V (vs Li/Li(+)). However, research has shown that extensive electrolyte decomposition and the formation of a surface passivation layer results when LMNO is implemented as a cathode in electrochemical cells. As a result of the high surface area associated with nanosized particles, manganese ion dissolution results in capacity fading over prolonged cycling. In order to prevent these detrimental effects without compromising electrochemical performance, various coating methods have been explored. In this work, TiO2 and Al2O3 thin films were deposited using atomic layer deposition (ALD) on the surface of LNMO particles. This resulted in effective surface protection by prevention of electrolyte side reactions and a sharp reduction in resistance at the electrode/electrolyte interface region.
Some Aspects of Preventing Coronary Heart Disease

Coronary heart disease (CHD) is the leading cause of mortality in the industrialized world and that might also soon be the case in other parts of the world. There are several easily measured and potentially modifiable risk factors that account for a substantial proportion of the risk of CHD. The effect of risk factors interventions appears to be consistent in both genders, across different geographic regions, and by all ethnic groups, suggesting that approaches to prevention can be based on similar principles worldwide. Optimal target levels for serum cholesterol and blood pressure are not yet clear. Future risk CHD reduction will mainly be achieved by improved primary prevention.
Journal of Enterprise Information Management Emerald Article : Enterprise content management research : a comprehensive review

Purpose – The purpose of this paper is to provide a comprehensive literature review of enterprise content management (ECM) research, a conceptual framework of areas of concern regarding ECM, and an agenda for future ECM research, based on the review and conceptual framework. Design/methodology/approach – To gain an understanding of the ECM literature, a structured research approach is adopted, consisting of two phases. The first phase consists of identifying the relevant ECM research papers. In the second phase, the analysis phase, the current ECM research is categorized based on three structural pillars: system component dimensions, system lifecycle, and strategic managerial aspects. Findings – After a review and classification of 91 ECM publications, it is found that ECM involves several sophisticated and interacting technical, social, organizational, and business aspects. The current ECM literature can be grouped around three main pillars: the first pillar consists of the four ECM component dimensions (tools, strategy, process, and people). The second pillar is the enterprise system lifecycle (adoption, acquisition, evolution, and evaluation). The final pillar is the strategic managerial aspect (change management, and management commitment). Based on the review and a proposed conceptual framework, an agenda for future research around the aforementioned three pillars is suggested. Originality/value – There is a lack of ECM meta-analysis research that explains the current state of the field. This paper contributes to information systems research by describing and classifying the published literature in ECM and by pointing out the gaps where further research is most needed. Furthermore, the paper provides a framework that may provide a conceptual structure for future studies.