Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychosocial Work Environment Among Employed Swedish Dairy and Pig Farmworkers

ABSTRACT The purpose of this study was to investigate the psychosocial work environment for employed dairy and pig farmworkers in southern Sweden and to identify potential risk factors related to the psychosocial work environment for the development of musculoskeletal disorders (MSDs). Thirty-seven workers on 10 dairy farms and 30 workers on 10 pig farms participated in the study. The study was based on a Swedish translation of the short version of the Copenhagen Psychosocial Questionnaire (COPSOQ) for analyses of self-perceived psychosocial work environment and the general Nordic questionnaire for analyses of self-perceived MSDs. In general, the psychosocial work environment was assessed as “good” by both the dairy and pig farmworkers. However, the dairy and pig farmworkers experienced lower work demands, poorer general and mental health, and poorer vitality (physical and mental strength, vigor, and energy) compared to other occupations. Furthermore, the results indicated that the quality of leadership, feedback, and social support at work were poorer at the dairy farms than at the pig farms. No significant risk factors related to the psychosocial work environment were identified for MSDs in “the back” and in the “upper extremities. ” This study indicates that the psychosocial work environment for the dairy and pig farmworkers may well be improved in order to promote these workplaces as attractive and healthful. This especially seems to be the case concerning the quality of leadership, feedback, and social support at work for the dairy farmworkers. Furthermore, the present study suggests the probability that physical factors are more likely to lead to MSDs among employed livestock workers than factors related to the psychosocial work environment.
DNA-Drug Recognition and Effects on Topoisomerase 11-mediated Cytotoxicity A THREE-MODE BINDING MODEL FOR ELLIPTICINE DERIVATIVES*

and topoisomerase 11-mediated DNA breaks induced in vitro by ellipticine derivatives were examined in connection with ‘H NMR and cir- cular dichroism (CD) studies on molecular structures and interactions of drugs with DNA. The compounds included four 9-hydroxyellipticine and two 7-hydrox-yisoellipticine derivatives. Structure-activity relationships indicated that a change in nitrogen atom position in the pyridinic ring greatly affected drug effects both on topoisomerase 11 action and cytotoxicity to L1210 cells. The four 9-hydroxyellipticinederivatives yielded bell-shaped curves in in vitro topoisomerase 11-me-diated DNA break assays, whereas the two 7-hydrox- yisoellipticine derivatives demonstrated an almost linear increase at the same concentration (0-10 pM). In both cases, the intensity of cleavage was modulated by the position and the degree of methylation on the pyr- idinic ring, and results were correlated with cytotoxic activity expressed as the in vitro IDs0 values for L1210 leukemia cells. ’H NMR experiments performed on free drug molecules in solution revealed that the two pro- tons (a and 8) contiguous to the biologically important hydroxy group were sensitive
Comparative Analysis of Clinical Effects of Mineral Trioxide Aggregate in the Treatment of Endodontic Diseases

Background: We aimed to evaluate the efficacy of mineral trioxide aggregate (MTA) in the treatment of endodontic disease. Methods: Oversell, 384 patients with endodontic disease treated in Xuzhou Stomatological Hospital, Xuzhou, China, from June 2015 to June 2017 were selected, and randomly divided into four groups with 96 cases per group. The repair effects of MTA, zinc phosphate cement (ZPC), silver amalgam and light-curing calcium hydroxide (LCH) on the teeth and dental pulp of patients in the four groups were compared. Meanwhile, the ill symptoms of the patients were observed to confirm whether they could be alleviated. Besides, whether the repair effects were related to ages of patients, perforation diameters of diseased teeth and repair materials was discussed. Results: The success rates of MTA group, ZPC group, LCH group and silver amalgam group were 90.6%, 68.7%, 70.8% and 52.1%, respectively. The success rate of MTA group was significantly higher than that of ZPC group, silver amalgam group and LCH group. When the success rates of four groups were compared, the differences were statistically significant (P=0.0072). The patient's age, repair material and perforation diameter were positively correlated with MTA repair effect (P=0.003, P=0.002, P=0.01). The patients' teeth in each group were repaired with different materials, and the reexamination was conducted 4 weeks later. Three patients in the silver amalgam group were found to have gingival swelling. Conclusion: The therapeutic effect of MTA was significant in the treatment of endodontic disease, and it is worthy of clinical application.
Identification of Candida albicans using different culture media and its association in leukoplakia and oral squamous cell carcinoma

Context: Candida, leukoplakia and oral squamous cell carcinoma. Aims: The aim of the present study has assessed the association of Candida albicans with normal control group, leukoplakia and oral squamous cell carcinoma lesions of the oral cavity by using cornmeal broth +5% milk and milk serum liquid culture media. Settings and Design: Thepresent study comprised of total 80 patients,which included, 30 patients of Leukoplakia, 30 patients of oral squamous cell carcinoma and normal control group comprised of 20 healthy individuals who were not having any relevant medical, dental and habit history. Subjects and Methods: Saliva and Biopsy was taken from clinically suspected leukoplakia and oral squamous cell carcinoma lesions for the confirmation of histopathological diagnosis. Saliva samples were inoculated for fungal growth in Sabouraud Dextrose Agar, and culture-positive samples had undergone for the germ tube test. Germ tube-positive samples were further taken for chlamydospore production in milk serum and cornmeal broth +5% milk media separately at 8 and 16 h. Statistical Analysis Used: Chi-square test, Fischer extract test. Results: In the normal control group, no fungus growth was found; however, leukoplakia and oral squamous cell carcinoma showed fungus growth with positive germ tube test and chlamydospore formation; the result also showed rapid and quantitatively more chlamydospore formation in cornmeal broth +5% milk in comparison to serum milk culture media. There was no growth of Candida in mild and moderate form of leukoplakia. Whereas in a severe form of leukoplakia, there was more quantitative chlamydospore growth in cornmeal broth +5% milk liquid media. Conclusions: In this study, we have tried to compare the efficacy of cornmeal broth +5% milk and milk serum for the identification of C. albicans. Both the culture media were able to promote the growth of chlamydospore in C. albicans. Among different grades of leukoplakia, the growth of C. albicans was seen in severe dysplastic patient only while mild and moderate dysplasia showed no Candidal growth.
Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression.

PURPOSE To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC). PATIENTS AND METHODS One thousand three hundred four patients who were irradiated from January 1992 to December 2003 were included in this retrospective review. The schedules of 1 x 8 Gy in 1 day (n = 261), 5 x 4 Gy in 1 week (n = 279), 10 x 3 Gy in 2 weeks (n = 274), 15 x 2.5 Gy in 3 weeks (n = 233), and 20 x 2 Gy in 4 weeks (n = 257) were compared for motor function, ambulatory status, and in-field recurrences. The following potential prognostic factors were investigated: age, sex, performance status, histology, number of involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits before RT. A multivariate analysis was performed with the ordered logit model. RESULTS Motor function improved in 26% (1 x 8 Gy), 28% (5 x 4 Gy), 27% (10 x 3 Gy), 31% (15 x 2.5 Gy), and 28% (20 x 2 Gy); and posttreatment ambulatory rates were 69%, 68%, 63%, 66%, and 74% (P = .578), respectively. On multivariate analysis, age, performance status, primary tumor, involved vertebra, interval from cancer diagnosis to MSCC, pretreatment ambulatory status, and time of developing motor deficits were significantly associated with functional outcome, whereas the RT schedule was not. Acute toxicity was mild, and late toxicity was not observed. In-field recurrence rates at 2 years were 24% (1 x 8 Gy), 26% (5 x 4 Gy), 14% (10 x 3 Gy), 9% (15 x 2.5 Gy), and 7% (20 x 2 Gy) (P < .001). Neither the difference between 1 x 8 Gy and 5 x 4 Gy (P = .44) nor between 10 x 3 Gy, 15 x 2.5 Gy, and 20 x 2 Gy (P = .71) was significant. CONCLUSION The five RT schedules provided similar functional outcome. The three more protracted schedules seemed to result in fewer in-field recurrences. To minimize treatment time, the following two schedules are recommended: 1 x 8 Gy for patients with poor predicted survival and 10 x 3 Gy for other patients. Results should be confirmed in a prospective randomized trial.
The tissue plasminogen activator gene promoter: a novel tool for radiogenic gene therapy of the prostate?

Radiation therapy is a treatment modality routinely used in cancer management so it is not unexpected that radiation‐inducible promoters have emerged as an attractive tool for controlled gene therapy. The human tissue plasminogen activator gene promoter (t‐PA) has been proposed as a candidate for radiogenic gene therapy, but has not been exploited to date. The purpose of this study was to evaluate the potential of this promoter to drive the expression of a reporter gene, the green fluorescent protein (GFP), in response to radiation exposure.
Construct Validity of Adolescents’ Self-Reported Big Five Personality Traits

While there are a number of short personality trait measures that have been validated for use with adults, few are specifically validated for use with adolescents. To trust such measures, it must be demonstrated that they have adequate construct validity. According to the view of construct validity as a unifying form of validity requiring the integration of different complementary sources of information, this article reports the evaluation of content, factor, convergent, and criterion validities as well as reliability of adolescents’ self-reported personality traits. Moreover, this study sought to address an inherent potential limitation of short personality trait measures, namely their limited conceptual breadth. In this study, starting with items from a known measure, after the language-level was adjusted for use with adolescents, items tapping fundamental primary traits were added to determine the impact of added conceptual breadth on the psychometric properties of the scales. The resulting new measure was named the Big Five Personality Trait Short Questionnaire (BFPTSQ). A group of expert judges considered the items to have adequate content validity. Using data from a community sample of early adolescents, the results confirmed the factor validity of the Big Five structure in adolescence as well as its measurement invariance across genders. More important, the added items did improve the convergent and criterion validities of the scales, but did not negatively affect their reliability. This study supports the construct validity of adolescents’ self-reported personality traits and points to the importance of conceptual breadth in short personality measures.
Robust multiclass ECG arrhythmia detection using balanced trained neural network

Classification of data including Electrocardiogram (ECG) is significantly affected with imbalanced class distribution. Efforts have been made to learn from the imbalanced data to improve the performance of the classifier. This paper presents the result of ECG arrhythmia detection of normal(N) beat and five different arrhythmia beats based on balanced input to the classifier for training only. The ECG signals are taken from MIT-BIH arrhythmia database. A three layer feedforward Backpropagation neural network(FFBNN) is used for classification. The input for training the network is perfectly balanced, taking same number of patterns from each class. After training the trained network is used for classifying completely different dataset. We achieved average accuracy, sensitivity, & specificity of 99.24%, 94.90% & 99.57% respectively. The effect of balanced input at the time of training is shown.
Pediatric malaria: 8-year case series in Atlanta, Georgia, and review of the literature.

BACKGROUND Although malaria is frequent in travelers, it is often misdiagnosed on initial presentation, especially in children. The objective of this study is to describe epidemiology, clinical and laboratory presentation, and treatment of children with malaria in the United States. METHODS We performed a retrospective review of 50 confirmed cases of malaria from two pediatric metropolitan hospitals in Atlanta, GA, from 2000 to 2008. RESULTS Malarial smears were performed in 385 unique patients; 50 (12.6%) were positive. American children who had visited family and friends in malaria-endemic countries comprised 62% of our cases. Most cases visited Nigeria or Cameroon; all but three traveled to Africa. Three patients presented 8 to 12 months following travel. Plasmodium falciparum was diagnosed most frequently (72%). Most patients had low-level parasitemia (<1%). Gametocytes were rarely identified. Treatment was primarily with quinine and either doxycycline or clindamycin, and transfusion was rare. All patients responded rapidly to treatment. Although seven (14%) had hyperparasitemia (> 5%), no fatalities or long-term sequelae were seen. CONCLUSIONS Malarial diagnosis can be difficult in children because parasitemia is usually below 1%. A high index of suspicion is required in patients who have traveled to Africa.
Help-Seeking Behavior and Psychological Distress by Age in a Nationally Representative Sample of Japanese Employees

Background The present study aimed to examine the association between the presence/absence of help-seeking behavior (ie, behavior aimed at obtaining assistance from others to improve a situation or problem) and psychological distress among private and public employees by age group using a nationally representative sample of the Japanese population. Methods The present study analyzed data obtained from the 2016 Comprehensive Survey of Living Conditions, a nationwide cross-sectional survey. Of 568,426 participants, 78,284 private and public employees aged 20 to 59 years, who were receiving no mental health services at the time of the survey and reported at least one stressor in daily life, were eligible. The primary outcome measure was self-rated psychological distress as measured by the Kessler Psychological Distress Scale. Multiple logistic regression analyses were carried out separately by age group, adjusting for sociodemographic and job/life-related factors. Results The proportion of participants not showing help-seeking behavior was significantly higher among those aged 40–59 years compared to those aged 20–39 (30.5% and 22.7%, respectively; P < 0.001). Participants without help-seeking behavior had significantly higher odds ratios (ORs) for psychological distress, regardless of age group (OR = 1.9 [95% confidence interval (CI), 1.6–2.0] and OR = 1.6 [95% CI, 1.4–1.7] for the age 20–39 years and 40–59 years groups, respectively), compared to those showing help-seeking behavior. Conclusions Participants not showing help-seeking behavior were more likely to have severe psychological distress, and this trend appeared to be slightly stronger among those aged 20–39 years. These findings suggest that promoting help-seeking behavior is important for improving mental health among workers.
Bilateral intracranial vertebral artery disease in the New England Medical Center, Posterior Circulation Registry.

BACKGROUND Previous studies of patients with bilateral intracranial vertebral artery (ICVA) disease were selective and retrospective. METHODS We studied risk factors, vascular lesions, symptoms, signs, and outcomes in patients with bilateral ICVA disease among 430 patients in the New England Medical Center Posterior Circulation Registry. RESULTS Forty-two patients had bilateral ICVA occlusive disease (18 had bilateral stenosis; 16, unilateral occlusion and contralateral stenosis; and 8, bilateral occlusion). The most common risk factors were hypertension (32/42 [76%]) and hyperlipidemia (22/42 [52%]). Sixteen patients (38%) had transient ischemic attacks (TIAs) only; 18 (43%), TIAs before stroke. Occlusive vascular disease also involved the basilar artery in 29 patients (69%), the extracranial vertebral arteries in 18 (43%), and the internal carotid arteries in 11 (26%). Only 6 patients had no other major vascular lesion. Cerebellar symptoms were common. Among 30 patients with infarction, 21 (70%) had proximal intracranial territory involvement, and 15 (50%) had distal territory involvement. The location of occlusive lesions in relation to posterior inferior cerebellar artery origins did not significantly influence prognosis. During follow-up, 31 patients had no symptoms or slight disability, 2 had progression, and 7 died. Among 7 patients with poor outcome, 6 also had basilar artery stenosis or occlusion and 5 had proximal and distal intracranial territory infarcts. CONCLUSIONS Most patients with bilateral ICVA occlusive disease have hypertension, other major occlusive lesions, and TIAs before stroke. Short- and long-term outcomes are usually favorable, but patients with bilateral ICVA and basilar artery-occlusive lesions often have poor outcomes.
Alterations in the relative abundance of Faecalibacterium prausnitzii correlate with changes in fecal calprotectin in patients with ileal Crohn’s disease: a longitudinal study

Abstract Objectives: Crohn’s disease is characterized by a gut dysbiosis with decreased abundance of butyrate producers such as Faecalibacterium prausnitzii. Although F. prausnitzii secretes anti-inflammatory molecules, few studies have addressed the importance of F. prausnitzii in a longitudinal setting. We aimed to examine the relationship between temporal profiles of F. prausnitzii, the C. leptum group, overall butyrate production, and inflammatory activity. Material and methods: Fecal samples (n = 59) were collected every third month from nine patients with ileal Crohn’s disease. The abundance of F. prausnitzii and C. leptum was quantified relative to the total amount of bacteria using quantitative-PCR. To assess butyrate production of gut microbiota, gene copy numbers of the butyryl-CoA:acetate-CoA transferase (BCoAT) gene were quantified by qPCR. The inflammatory activity was defined by fecal (f)-calprotectin. Results: No correlation between the relative abundance of F. prausnitzii, the C. leptum group, or copy numbers of the BCoAT gene, and f-calprotectin was observed in the total sample set. By analyzing alterations between consecutive samples, a negative correlation between changes in the relative abundance of F. prausnitzii and f-calprotectin was observed (R = −0.39; p = .009). Changes in C. leptum (R = −0.18, p = .23) and number of copies of the BCoAT gene (R = −0.12; p = .42) did not correlate with f-calprotectin. Conclusions: There was an inverse correlation between temporal changes in the relative abundance of F. prausnitzii, but not overall butyrate producing capacity, and changes in inflammatory activity in ileal Crohn’s disease. These findings indicate that F. prausnitzii may play a role in gut homeostasis, even though causality is still to be demonstrated.
Objective assessment of perceived effort in listening by employing EEG feature

The adjustment of hearing aid devices can heavily depend on the subjective feedback of the patients. Our aim is to investigate measures that can be used objectively to state a subject's listening effort. To obtain a comprehensive and reliable measure as an indicator for a person's listening effort, we need to have a better understanding of electroencephalograpic (EEG) activities. Decoding EEG signals specifically by the analysis of the instantaneous phase information has been a new trend in the last decades. Throughout many studies conducted in the past, it has been shown that the instantaneous phase of oscillatory signals reset in relation to various cognitive processes. This is based on a hypothesis presented for the generation of event related potentials. In this study, we measure the degree of phase re-organization through fitting a von Mises distribution to EEG recordings. The concentration parameter of a von Mises distribution has been shown as an informative feature for reflecting the level of attention. This feature has been used for predicting the listening effort and the results are compared among three different hearing aid settings.
In vitro toxicity of hydrogen peroxide against normal vs. tumor rat hepatocytes: Role of catalase and of the glutathione redox cycle

Hydrogen peroxide produced by stimulated phagocytic cells or during the metabolism of drugs, is toxic to various cell types. The aim of this study was to investigate its toxicity against normal vs. tumor rat hepatocytes. Isolated normal hepatocytes and tumor hepatocytes from three hepatocarcinoma cell lines, Fao, C2 (Faof1 C2) and HTC, were incubated in the presence of a H2O2‐generating system consisting of glucose and varied concentrations of glucose oxidase. The toxicity of H2O2 was quantified by measuring the percentage of lactate dehydrogenase activity released in the culture medium after various times of incubation. By comparison to normal hepatocytes, tumor hepatocytes exhibited an increased susceptibility to lysis by H2O2. At a concentration of 100 mU per ml, glucose oxidase induced a lactate dehydrogenase activity release of only 6.1 ± 2.2% (mean ± S.E.) from normal hepatocytes and of 71.0 ± 2.9, 45.5 ± 2.5 and 34.7 ± 3.4% from Fao, C2 and HTC cells, respectively, after an 18‐hr incubation. At a concentration of 10 mU per ml, glucose oxidase had no toxic effect to normal hepatocytes or HTC cells, whereas it induced a lactate dehydrogenase activity release of 58.7 ± 7.6 and 51.2 ± 5.6% from Fao and C2 cells, respectively. In addition, the time courses of lactate dehydrogenase activity release, studied with 500 mU per ml glucose oxidase, demonstrated that Fao cells, C2 cells and, to a lesser degree, HTC cells were lysed more rapidly than normal hepatocytes. The toxicity of glucose oxidase was suppressed by the addition of catalase, indicating that it was actually mediated by H2O2. Catalase activity expressed per cell number and the components of the glutathione redox cycle were decreased in tumor cells by comparison to normal hepatocytes. In addition, treatment of normal hepatocytes with aminotriazole, an inhibitor of catalase, and with 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea, an inhibitor of glutathione reductase, rendered these cells as susceptible as tumor hepatocytes to the effects of H2O2. In conclusion, tumor hepatocytes were more susceptible to the toxic effect of H2O2 than normal hepatocytes. This difference is probably due to a decrease in the H2O2 detoxication systems that we studied, i.e. catalase and glutathione redox cycle, in tumor cells.
Use of magnetic resonance imaging to assess renal structure and function in reflux nephropathy

Aim: Despite numerous potential advantages, the role of magnetic resonance imaging (MRI) in depicting structural and functional abnormalities in kidney disease has not been well addressed. In reflux nephropathy in particular, nuclear scintigraphy (NS) has become the diagnostic gold standard, however, other imaging modalities may be required for adequate clinical appraisal. We therefore assessed the use of MRI in reflux nephropathy, comparing findings with those obtained using conventional imaging techniques.