Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Resolution Analysis of Parent-of-Origin Allelic Expression in the Arabidopsis Endosperm

Genomic imprinting is an epigenetic phenomenon leading to parent-of-origin specific differential expression of maternally and paternally inherited alleles. In plants, genomic imprinting has mainly been observed in the endosperm, an ephemeral triploid tissue derived after fertilization of the diploid central cell with a haploid sperm cell. In an effort to identify novel imprinted genes in Arabidopsis thaliana, we generated deep sequencing RNA profiles of F1 hybrid seeds derived after reciprocal crosses of Arabidopsis Col-0 and Bur-0 accessions. Using polymorphic sites to quantify allele-specific expression levels, we could identify more than 60 genes with potential parent-of-origin specific expression. By analyzing the distribution of DNA methylation and epigenetic marks established by Polycomb group (PcG) proteins using publicly available datasets, we suggest that for maternally expressed genes (MEGs) repression of the paternally inherited alleles largely depends on DNA methylation or PcG-mediated repression, whereas repression of the maternal alleles of paternally expressed genes (PEGs) predominantly depends on PcG proteins. While maternal alleles of MEGs are also targeted by PcG proteins, such targeting does not cause complete repression. Candidate MEGs and PEGs are enriched for cis-proximal transposons, suggesting that transposons might be a driving force for the evolution of imprinted genes in Arabidopsis. In addition, we find that MEGs and PEGs are significantly faster evolving when compared to other genes in the genome. In contrast to the predominant location of mammalian imprinted genes in clusters, cluster formation was only detected for few MEGs and PEGs, suggesting that clustering is not a major requirement for imprinted gene regulation in Arabidopsis.
Ocular penetration studies. II. Topical administration of prednisolone.

This study has outlined the rate and duration of penetration of tritiated prednisolone into the aqueous humor following a single clinical dose. The prednisolone labeled with tritium was incorporated into a commercial preparation. The concentration of drug reached a peak of 7. 651μg/gm of aqueous humor at 30 minutes and decreased to a level of 2. 176μg/gm at 240 minutes. These results are compared with the penetration of tritiated dexamethasone.
'If I had a friend in a wheelchair': children's thoughts on disabilities.

The purpose of the present study was to examine what notions there are among ordinary preschool children and schoolchildren about physically handicapped children using wheelchairs. Forty-eight children-16 children of preschool age (half boys, half girls, aged around 6), 16 children in primary school class 2 (half boys, half girls, aged around 8) and 16 children in class 4 (half boys, half girls, aged around 8)-constituted the investigated group. The method used was a combination of drawings produced by the children themselves serving as a projective image, interview questions in connection with the drawings and a self-assessment scale, based on Osgood's semantic differential technique. The results showed that most children had favourable attitudes towards a child in a wheelchair. They were willing to include the disabled child in their games and recreational activities, and they considered that the disabled child would have many friends and a high self-esteem. However, they saw real obstacles for the disabled child both in play situations and in other environmental settings. No tangible differences between the sexes could be found; however, differences by age were present. The results were discussed with regard to earlier research and topics for further research are suggested.
The Value of Time in Early Modern English Literature

stantly cautioned of its dangers, the text was widely available in a variety of forms. Brownlee focuses here on poetic paraphrases, including William Baldwin’s Canticles (1549), Francis Quarles’s Sions sonets (1624), and Robert Aylett’s Song of Songs (1621). Building on recent scholarship on women readers by Femke Molekamp, Brownlee’s fifth chapter explores female reinterpreters of Mary. In The mothers blessing (1616), Dorothy Leigh “uncovers a network of women across biblical history whose alternative virtues foreshadow the spiritual and political impact of Mary’s maternity and, consequently, the significance of contemporary women” (154). In a similar typological manner, Aemilia Lanyer’s Salve Deus Rex Judaeorum (1611) uses an account of the fall in “Eve’s Apologie” that lends typological strength to her revisionist account of Mary. The final chapter, on Revelation, continues the book’s investigation of forms of allegory and typology characterizing popular Protestant hermeneutics. The chapter considers “how scripture’s most sustained account of the end-point of history was read and applied in the early modern present” (169). Although readers may wish for more defined argumentation, this book provides valuable insight into the complex mechanics of early modern biblical interpretation and literary culture.
Fragment grouping via the principle of perceptual occlusion

Bounding contours of physical objects are often fragmented by other occluding objects. Long-distance perceptual grouping seeks to join fragments belonging to the same object. Approaches to grouping based on invariants assume objects are in restricted classes, while those based on minimal energy continuations assume a shape for the missing contours and require this shape to drive the grouping process. We propose the more general principle that those fragments should be grouped whose fragmentation could have arisen from a generic occluder. The gap skeleton is introduced as a representation of this virtual occluder, and an algorithm for computing it is given.
The Effect of Physical Activity and the Use of Active Video Games: Exergames in Children and Adolescents: A Systematic Review

The aim of this study is to develop a systematic review on the relationship between the use of active video games “exergames” and the practice of physical activity. The Web of Science (WOS) repository was used as the main search engine, using as criteria the selection of longitudinal and experimental studies published in the last five years. A total of eight research papers were obtained, in which intervention programs based on the use of exergames were applied to improve different parameters, such as adherence to Physical Activity practice or improvement on a psychological level. As the main findings, it was possible to observe the need to include these types of devices in the classroom since they can work transversally across much content, and the resources are so accessible that they allow improvements at academic level. Likewise, they favor motivation to physical exercise since with adequate volume and intensity parameters, they are related to healthier lifestyles, and the areas of motor skills and logical thinking benefited the most.
An experimental approach to the health-monitoring of a silicon carbide MOSFET-based power module

This paper deals with an overview of Silicon Carbide MOSFET-based power module failure modes and an experimental health-monitoring approach to detect them. The power module reliability question has recently emerged according to the development of converters in industrial fields such as: aerospace, automotive, traction… Nowadays, converters have a key role in the power transmission line. Besides, the power requirement of these converters is ever increasing. This constraint has pushed researchers into new technologies increasing the power density in converters which are increasingly more compact and lightweight. In our application, we use silicon carbide chips due to their better performance compared to other technologies. The interconnections and the materials have been adapted to the higher temperature range of a SiC chip. Despite optimization, the silicon carbide MOSFET-based power modules still present weaknesses and failures in use. The aim of this paper is to understand and moreover to highlight the power module physics of failure to trigger the most common failure types, to find a way to follow them. Finally, it presents a relevant test plan and the test circuits associated to trigger and study these expected failures.
Block source coding theory for asymptotically mean stationary sources

Several properties of operational and information theoretic distortion rate functions and of mutual information rate are developed for asymptotically mean stationary (ams) processes with standard alphabets and used to prove a block source coding theorem for ergodic ams sources. In the development we prove an ergodic decomposition of the mutual information rate of ams sources, we show that the operational distortion rate function of an ams source equals that of its stationary mean, and we provide a new and direct proof of the equality of the ergodic and stationary process distortion rate functions. The latter result yields a proof of the block source coding theorem not requiring the Nedoma decomposition and complicated code construction used by Gallager and Berger.
Sexual Conflict and the Energetic Costs of Mating and Mate Choice in Water Striders

Analyses of intersexual conflicts of interest over courtship, mating, or mate guarding require an understanding of the physiological costs of sexual interaction. Repeated respirometric measures of energetic expenditure were taken on female Aquarius remigis while unladen and while carrying a mating male, a small metal weight, or a euthanized male. Unladen “cruising” locomotion consumed an average of 334.6 μW of energy ( \documentclass{aastex} \usepackage{amsbsy} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{bm} \usepackage{mathrsfs} \usepackage{pifont} \usepackage{stmaryrd} \usepackage{textcomp} \usepackage{portland,xspace} \usepackage{amsmath,amsxtra} \usepackage[OT2,OT1]{fontenc} \newcommand\cyr{ \renewcommand\rmdefault{wncyr} \renewcommand\sfdefault{wncyss} \renewcommand\encodingdefault{OT2} \normalfont \selectfont} \DeclareTextFontCommand{\textcyr}{\cyr} \pagestyle{empty} \DeclareMathSizes{10}{9}{7}{6} \begin{document} \landscape $$\mathrm{82\,J\,kg}\,^{- 1}\,\mathrm{m}\,^{- 1}$$ \end{document} ); this estimate of the cost of locomotion coincides with measures from voluntarily locomoting arthropods of similar mass and represents the first energetic measure of skating on a water surface. Cruising females carrying males or metal weights consumed 24% and 28% more energy than unladen females, respectively. Females engaged in “escape” locomotion consumed 43% more energy while carrying a male than while unladen. Further, our study shows that premating struggles, and therefore selective mating deccisions, are energetically costly. Struggling females consumed an average of 936.6 μW, a 126% increase compared to cruising, nonstruggling females, and 64% more than mating females engaged in escape locomotion. We develop a quantitative model showing that at a certain harassment rate threshold, accepting superfluous matings becomes the “best of a bad job” for females.
Anthracycline cardiotoxicity: an update on mechanisms, monitoring and prevention

Anthracycline chemotherapy causes dose-related cardiomyocyte injury and death leading to left ventricular dysfunction. Clinical heart failure may ensue in up to 5% of high-risk patients. Improved cancer survival together with better awareness of the late effects of cardiotoxicity has led to growing recognition of the need for surveillance of anthracycline-treated cancer survivors with early intervention to treat or prevent heart failure. The main mechanism of anthracycline cardiotoxicity is now thought to be through inhibition of topoisomerase 2β resulting in activation of cell death pathways and inhibition of mitochondrial biogenesis. In addition to cumulative anthracycline dose, age and pre-existing cardiac disease are risk markers for cardiotoxicity. Genetic susceptibility factors will help identify susceptible patients in the future. Cardiac imaging with echocardiographic measurement of global longitudinal strain and cardiac troponin detect early myocardial injury prior to the development of left ventricular dysfunction. There is no consensus on how best to monitor anthracycline cardiotoxicity although guidelines advocate quantification of left ventricular ejection fraction before and after chemotherapy with additional scanning being justified in high-risk patients. Patients developing significant left ventricular dysfunction with or without clinical heart failure should be treated according to established guidelines. Liposomal encapsulation reduces anthracycline cardiotoxicity. Dexrazoxane administration with anthracycline interferes with binding to topoisomerase 2β and reduces both cardiotoxicity and subsequent heart failure in high-risk patients. Angiotensin inhibition and β-blockade are also protective and appear to prevent the development of left ventricular dysfunction when given prior or during chemotherapy in patients exhibiting early signs of cardiotoxicity.
Personalized Recommendation Based on Reviews and Ratings Alleviating the Sparsity Problem of Collaborative Filtering

With the development of e-commerce, shopping on-line is becoming more and more popular. When we need to decide whether to purchase a product or not on line, the opinions of others become important. The convenience of new web technologies enables us to freely express our opinions and reviews for various products we have purchased which leads to a serious problem, information overloading. How to mine these review data to understand customers' preferences and make recommendations is crucial to merchants and researchers. Traditional collaborative filtering (CF) algorithm is one of the most successful recommendation system technologies. The core idea of CF algorithm is to recommend products based on other people who have similar tastes with target users. However, the ability of CF is limited by the sparsity problem, which is very common in reality. The reason derives from the fact that traditional CF method only takes users' ratings into account. In this paper, we propose a new personalized recommendation model, i.e. topic model based collaborative filtering (TMCF) utilizing users' reviews and ratings. We exploit extended LDA model to generate topic allocations for each review and then obtain each user's preference. Moreover, a new metric is designed to measure similarity between users alleviating the sparsity problem to a large extent. Finally, recommendations are made based on similar users' ratings. Experiments on seven data sets indicate better prediction accuracy than other traditional and state-of-the-art methods with substantial improvement in alleviating the sparsity problem.
Testosterone improves antidepressant-emergent loss of libido in women: findings from a randomized, double-blind, placebo-controlled trial.

INTRODUCTION Female sexual dysfunction is a side effect of selective serotonin reuptake inhibitor (SSRI)/serotonin noradrenalin reuptake inhibitor (SNRI) therapy. AIMS The aim of this study is to investigate the efficacy of transdermal testosterone (TT) as a treatment for SSRI/SNRI-emergent loss of libido. METHODS This was a double-blind, randomized, placebo-controlled study. Forty-four women, aged 35-55 years, on a stable dose of SSRI or SNRI with treatment-emergent loss of libido were randomly allocated to treatment with a TT patch delivering 300 mcg of testosterone/day or an identical placebo patch (Pl) for 12 weeks. MAIN OUTCOME MEASURES The primary outcome measure was the change in the Sabbatsberg Sexual Self-rating Scale (SSS) total score over 12 weeks. The 4-week frequency of Satisfactory Sexual Events (SSEs) and the Female Sexual Distress Scale-Revised (FSDS-R) were also measured. RESULTS At baseline, there were no differences between the treatment groups. At week 12, the change in the SSS score did not differ between the two groups. The increase in the 4-week frequency of SSEs was significantly greater for the TT group than for the Pl group (an increase of 2.3 events vs. 0.1, P = 0.02). The between-group difference in the change in the FSDS-R score approached statistical significance (P = 0.06). The mean total serum testosterone level at 12 weeks in the TT group was 2.1 nmol/L. No women withdrew because of androgenic adverse events. CONCLUSIONS TT therapy resulted in a significant increase in the number of SSEs compared with Pl therapy in women with SSRI/SNRI-emergent loss of libido. The lack of improvement in the SSS total score may reflect lack of sensitivity of this instrument for the measurement of change in sexual function. This provides the first evidence that TT therapy may be a treatment option for women with SSRI/SNRI-emergent loss of libido who need to remain on their antidepressant therapy.
[Comments on management of hepatocellular carcinoma: an update].

美国肝病研究学会(American Association for the Study of Liver Diseases,AASLD)2005年发布的 是在国际上获得最广泛公认的肝细胞癌(HCC)临床诊断、治疗的指南,也是国际临床试验设计与评价最主要的依据. 2010年,AASLD根据5年来肝癌临床实践的循证医学证据,对2005年版指南进行全面更新,在线全文发表了 (以下简称 ),并历经若干小修改. 今年3月,在 杂志上正式发表了该 的要点. 本文重点评述 对2005年版指南的增补和修改内容[初稿部分刊登于 2011年第1期]。
In situ stresses in the North Sea and their applications: petroleum geomechanics from exploration to development

Present-day maximum horizontal stress (σ H ) is oriented northwest–southeast onshore North West Europe, reflecting the first-order control on intraplate stresses exerted by plate boundary forces. Stresses associated with deglaciation appear to influence the stress regime in the Northern North Sea, with σ H oriented E–W and a contemporary stress regime close to the transition between strike-slip and reverse faulting, i.e. σ H > σ v ~ σ h (where σ v and σ h are vertical and minimum horizontal stress respectively). Maximum horizontal stress orientations are highly variable in the Central North Sea and the stress regime within the sedimentary sequence appears to be detached from that in the basement. The stress regime in the sedimentary sequence of the Central North Sea is predominantly one of normal faulting with almost isotropic horizontal stresses (σ v > σ H ~ σ h ). Geomechanical risking of the likelihood of seal breach due to fracturing should incorporate the risk of reactivating sealing faults or fracturing intact cap seal rocks in shear or in tension. The risk of fracture-related seal breach is considered for stress regimes representative of the Northern and Central North Seas. Generally, reactivation of optimally oriented faults and/or shear fracturing of intact cap rock are the most likely mechanisms of fracture-related seal breach. However, in the Central North Sea overpressured scenario, tensile failure is the most likely mechanism of fracture-related seal breach. In situ stress data have value throughout the life cycle of a field. The implications of the stress regimes representative of the Northern and Central North Seas for naturally fractured reservoirs, wellbore stability, water flooding and fracture stimulation are analysed. These issues are stress-sensitive and the conclusions with respect to each issue differ significantly between the Northern and the Central North Sea because of their differing stress regimes.
Building L-shape footprint extraction from high resolution SAR image

Building extraction in SAR images is still a difficult task due to the geometric distortions, the electromagnetic wave interactions between adjacent targets, and the speckle noises. In this paper, a method for building L-shape footprint extraction from high resolution SAR images jointly using image segmentation and line detection is proposed. Experiments based on a TerraSAR-X image show that method proposed in this paper can accurately delineate the L-shape edges of buildings facing towards the SAR sensor.
Comparative Genome Sequencing of an Isogenic Pair of USA800 Clinical Methicillin-Resistant Staphylococcus aureus Isolates Obtained before and after Daptomycin Treatment Failure

ABSTRACT We describe here a clinical daptomycin treatment failure in a patient with recurrent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in whom daptomycin was administered after a failed empirical treatment course with vancomycin and piperacillin-tazobactam. We had the opportunity to compare the genome sequences of an isogenic pair of daptomycin-susceptible and -resistant MRSA isolates obtained before and after initiation of daptomycin therapy, respectively. The genotype of both isolates was USA800, ST5, SCCmec type IV, agr type II. There was no increase in cell wall thickness in the daptomycin-resistant strain despite having decreased susceptibility to both vancomycin and daptomycin. By comparing the genome sequences by pyrosequencing, we identified a polymorphism (S337L) in the tenth transmembrane segment of the multiple peptide resistance factor, MprF, encoding lysyl phosphatidylglycerol transferase. This enzyme has been shown previously to promote repulsion of daptomycin at the cell surface by addition of positively charged lysine to phosphatidylglycerol. Also, the hlb open reading frame (ORF) encoding the β-toxin was interrupted by a prophage in the daptomycin-susceptible strain; this phage was missing in the daptomycin-resistant isolate and the hlb ORF was restored. Loss of the phage in the resistant isolate also resulted in loss of the virulence factor genes clpP, scn, and sak. This is the first study to use pyrosequencing to compare the genomes of a daptomycin-susceptible/resistant MRSA isolate pair obtained during failed daptomycin therapy in humans.
A novel single-element dual-frequency ultrasound transducer for image-guided precision medicine

High-resolution ultrasound imaging of tissues provides a higher possibility for the early diagnosis of various diseases and plays an important role in high-precision targeted treatment. However, it unavoidably suffers from low penetration depth and short depth of field (DOF) due to its high operating frequency. A novel single-element dual-frequency ultrasound transducer (DFUT) has been designed and studied, which consists of three conductive metal layers, a large capacitive elastic layer used as the low-frequency capacitive micromachined ultrasonic transducer (CMUT), and a small piezoelectric layer used as the high-frequency piezoelectric micromachined ultrasonic transducer (PMUT). This capacitive-piezoelectric hybrid structure is able to operate at both CMUT and PMUT modes at two different frequencies. Both theoretical analysis and finite element method (FEM) simulations have been carried out towards the frequency performance and optimizing the dimensions of the DFUT. The results show that the novel structure could be in operation at both low frequency of 5.9MHz and high frequency of 26.6MHz, which can be adopted as imaging and/or therapy operations. With the combination of CMUT and PMUT modes, the single-element DFUT provides the advantages of high-resolution (<200μm for PMUT operation) and a wide detection distance (>3cm for CMUT operation), which may significantly inspire the imaging-guided precision medicine applications.