Miracle-dz/UniFAR-FTUs huggingface dataset:
Concurrent Endometrial Intraepithelial Carcinoma (EIC) and Serous Ovarian Cancer: Can EIC Be Seen as the Precursor Lesion?

Objective The pathogenesis of serous ovarian carcinoma (SOC) is still unknown. Recently, endometrial intraepithelial carcinoma (EIC) was proposed to be the precursor lesion of SOC. This study examines the model of EIC as precursor for SOC. Methods Cases of SOC with a noninvasive or superficially invasive serous lesion, a hyperplastic lesion with/without atypia, or EIC in the endometrium were selected for inclusion in this study. Tissue sections from both ovaries, the fallopian tubes, and the uterus were extensively reviewed by an expert gynecopathologist. For both EIC and SOC, immunostaining for p53, Ki-67, estrogen receptor, and progesterone receptor; TP53 mutation analysis; and in situ ploidy analysis were performed. Results Nine cases of SOC with concurrent EIC in the endometrium were identified. Immunostaining for p53, Ki-67, estrogen receptor, and progesterone receptor revealed almost identical expression patterns and similar intensities in each pair of EIC and coincident SOC. Identical TP53 mutations were found in SOC and coinciding EIC in 33% of the cases, suggesting a clonal origin. DNA ploidy analysis, as a marker for neoplastic progression, demonstrated an increased number of aneuploid nuclei in SOC compared to their corresponding EIC (P = 0.039). In addition, the mean amount of DNA per nucleus in SOC was higher (ie, more aneuploid) compared to EIC (P = 0.039). Conclusion This study provides a first indication of EIC as possible precursor lesion for SOC. This finding could have major clinical implications for future ovarian cancer management and underscores EIC as a possible target for early SOC detection and prevention.
Cilostazol Decreases Cerebral Arterial Pulsatility in Patients with Mild White Matter Hyperintensities: Subgroup Analysis from the Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) Study

Background: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of the Transcranial Doppler (ECLIPse) study showed a significant decrease in the transcranial Doppler (TCD) pulsatility index (PI) with cilostazol treatment at 90 days after acute lacunar infarction. The aim of the present study was to perform a subgroup analysis of the ECLIPse study in order to explore the effect of cilostazol in acute lacunar infarction based on cerebral white matter hyperintensities (WMH) volume. Methods: The ECLIPse study was a multicenter, randomized, double-blind, placebo-controlled trial that evaluated the difference between the efficacy of cilostazol and a placebo to reduce the PI in patients with acute lacunar infarction using serial TCD examinations. The primary outcome was changes in the PIs of the middle cerebral artery (MCA) and basilar artery at 14 and 90 days from the baseline TCD study. For this subgroup analysis, using semi-automated computerized software, the WMH volume was measured for those subjects for whom fluid-attenuated inversion recovery (FLAIR) images were available. Results: Of the 203 patients in eight hospitals in the ECLIPse study, 130 participants from six hospitals were included in this subgroup analysis. Cilostazol was given to 63 patients (48.5%) and placebo to 67 patients (51.5%). All baseline characteristics were well balanced across the two groups, and there were no significant differences in these characteristics except in the changes of PI from the baseline to the 90-day point. There was a significant decrease of TCD PIs at 90-day study from baseline in the cilostazol group (p = 0.02). The mean WMH volume was 11.57 cm3 (0.13-68.45, median 4.86) and the mean MCA PI was 0.95 (0.62-1.50). The changes in PIs from the baseline to 14 days and to 90 days were 0.09 (-0.21 to 0.33) and 0.10 (-0.22 to 0.36). While there were no significant correlations between WMH volume and the changes in PIs, a trend of inverse correlation was observed between the WMH volume and the changes in PIs from the baseline to the 90-day point. For the subgroup analysis, the WMH volume was dichotomized based on its median value (4.90 cm3). Cilostazol decreased the TCD PIs significantly at the 90-day point in patients with WMH volumes ≤4.9 cm3 (p = 0.002). Significant treatment effects were observed in the cilostazol group. Conclusions: This study showed that cilostazol decreased cerebral arterial pulsatility in patients with WMH. Our findings indicate the unique effect of cilostazol in small vessel disease (SVD), especially in patients with mild WMH changes. Further clinical trials focusing on WMH volume and clinical outcomes are required to assess the unique efficacy of cilostazol in SVD.
Dizziness after traumatic brain injury: Overview and measurement in the clinical setting

Traumatic brain injury (TBI) may result in a variety of cognitive, behavioural and physical impairments. Dizziness has been reported in up to 80% of cases within the first few days after injury. The literature was reviewed to attempt to delineate prevalence of dizziness as a symptom, impairments causing dizziness, the functional limitations it causes and its measurement. The literature provides widely differing estimates of prevalence and vestibular system dysfunction appears to be the best reported of impairments contributing to this symptom. The variety of results is discussed and other possible causes for dizziness were reviewed. Functional difficulties caused by dizziness were not reported for this population in the literature and review of cognitive impairments suggests that existing measurement tools for dizziness may be problematic in this population. Research on the functional impact of dizziness in the TBI population and measurement of these symptoms appears to be warranted.
A Review on Bio-Inspired Computing Algorithms and Application

Computer science and biology have enjoyed a long and fruitful relationship for decades. Biologists rely on computational methods to analyze and integrate large data sets, while several computational methods were inspired by the high level design principles of biological systems. Recently, these two directions have been converging. In this review, we argue that thinking computationally about biological processes may lead to more accurate models, which in turn can be used to improve the design of algorithms. We discuss the similar mechanisms and requirements shared by computational and biological processes and then present several recent studies that apply this joint analysis strategy to problems related to coordination, network analysis, and tracking and vision. We also discuss additional biological processes that can be studied in a similar manner and link them to potential computational problems. With the rapid accumulation of data detailing the inner workings of biological systems, we expect this direction of coupling biological and computational studies to greatly expand in the future.
A novel tube-based output feedback MPC for constrained linear systems

Model Predictive Control (MPC) is an advanced strategy for the control of multi-variable and constrained dynamical systems. Tube-based MPC is a robust control technique that handles uncertainties present in the model. Since full state information is seldom available in practical systems, the estimation error must also be taken into account in addition to model uncertainties to achieve closed-loop stability and constraint satisfaction despite estimation and model errors. In this paper, we propose a novel strategy for the design of a tube-based output feedback MPC which is independent of the estimation method employed. We formulate a control policy by choosing a candidate estimate that is consistent with the reachable sets of the system under control. The proposed method can be combined with any estimation scheme as long as the assumed error bounds are satisfied. We show that the proposed method is recursively feasible, robustly exponentially stable, and performs better than other available strategies.
Recovery of phenolic compounds from grape seeds: effect of extraction time and solid–liquid ratio

The aim of this research was to study the recovery of phenolic compounds from grape seeds, by-products from winemaking industries, using ethanolic solid–liquid extraction. For such a purpose, the combined effects of the extraction time (9, 19 and 29 h) and the solid–liquid ratio (0.10, 0.20 and 0.30 gdw mL−1), were investigated (where dw = dry waste). Results demonstrated that Pinot Noir seeds had high levels of both total polyphenols (73.66 mgGallic Acid Equivalent gdw−1) and flavonoids (30.90 mgCatechin Equivalent gdw−1), being the optimum extraction time 19 h approximately. The main phenolic compounds analysed with high performance liquid chromatography were catechin and quercetin with a maximum extraction yield obtained at 29 h (362.23 and 339.35 mg/100 gdw, respectively). Concentration of the polyphenols and their antiradical powers are demonstrated to have a significant linear correlation.
Current sensor on the base of permanent pre-chargeable amplifier

The sensitivity and delay of the amplifier are the key problems in the performance of current sensors (CS). For large devices which consist of several cells, for example 32 bit, the amplifier must react to 10-20 mV. The previous type of highly sensitive amplifier which is based on cascade and reference voltage [dill] can react to this level of voltage. But this model is not stable in respect to technological and parametric variation. In this paper we suggest triple cascade inverters with feedback by an unsymmetrical pass transistor which amplifies 1 mV without reference voltage. Monte Carlo SPICE simulation shows the stability of this model for parametric variation. We prepare the schematic of CS which includes a control unit with shunt transistors and evaluate the delay.
Strategies of SMM Management, Comparison of Instagram and Facebook Social Networks

SMM occupies an important role in the lives of people and so many people are represented in social networks, it provides the ideal platform for companies so they can communicate with their current and potential customers. This study continues to explore how companies can use social media marketing to build and maintain relationships with customers. This investigates through conducted research questions. How SMM is effective in terms of CRM? Can Facebook replace CRM system? Why do people choose to follow a company on Instagram? To analyze more clearly the focus will be on Instagram and Facebook applications, which in a short time acquired great popularity among private users as well as among the companies. The purpose of this study is to indicate the integration of customer relationship management (CRM) with social media marketing (SMM) strategies, and defines its benefits for business.
Dynamic timelines: visualizing the history of photography

This research reinvents the traditional timeline as a dynamic, three-dimensional framework for the interactive presentation of historical information. An experimental visualization of the history of photography uses visual techniques such as infinite zoom, translucency, and animation to present a database of over 200 annotated photographs from the collection of the George Eastman House. Dynamic, interactive design solutions address the communicative goals of allowing seamless micro and macro readings of information at several levels of detail and from multiple points of view.
Adult‐adult right hepatic lobe living donor liver transplantation for status 2a patients: Too little, too late

dult-adult right hepatic lobe living donor liver transplantation (LDLT) is a standard therapy at many transplant centers for selected patients with end-stage liver disease. 1-5 Nearly 10% of all liver transplan-tations performed last year in the United States used a living donor. 6 Despite the widespread application of LDLT, information is limited about the appropriate selection of living donor liver transplant recipients and their postoperative outcomes. Morbidity and mortality statistics are derived largely from single-center reports of small series of patients and surveys of transplant centers. Based on these limited
Thaumarchaeotal Signature Gene Distribution in Sediments of the Northern South China Sea: an Indicator of the Metabolic Intersection of the Marine Carbon, Nitrogen, and Phosphorus Cycles?

ABSTRACT Thaumarchaeota are abundant and active in marine waters, where they contribute to aerobic ammonia oxidation and light-independent carbon fixation. The ecological function of thaumarchaeota in marine sediments, however, has rarely been investigated, even though marine sediments constitute the majority of the Earth's surface. Thaumarchaeota in the upper layer of sediments may contribute significantly to the reservoir of nitrogen oxides in ocean waters and thus to productivity, including the assimilation of carbon. We tested this hypothesis in the northern South China Sea (nSCS), a section of a large oligotrophic marginal sea with limited influx of nutrients, including nitrogen, by investigating the diversity, abundance, community structure, and spatial distribution of thaumarchaeotal signatures in surface sediments. Quantitative real-time PCR using primers designed to detect 16S rRNA and amoA genes in sediment community DNA revealed a significantly higher abundance of pertinent thaumarchaeotal than betaproteobacterial genes. This finding correlates with high levels of hcd genes, a signature of thaumarchaeotal autotrophic carbon fixation. Thaumarchaeol, a signature lipid biomarker for thaumarchaeota, constituted the majority of archaeal lipids in marine sediments. Sediment temperature and organic P and silt contents were identified as key environmental factors shaping the community structure and distribution of the monitored thaumarchaeotal amoA genes. When the pore water PO4 3− concentration was controlled for via partial-correlation analysis, thaumarchaeotal amoA gene abundance significantly correlated with the sediment pore water NO2 − concentration, suggesting that the amoA-bearing thaumarchaeota contribute to nitrite production. Statistical analyses also suggest that thaumarchaeotal metabolism could serve as a pivotal intersection of the carbon, nitrogen, and phosphorus cycles in marine sediments.
Progress and recent trends in 48 V hybridisation and e-boosting technology on passenger vehicles – a review

Electrification of the powertrain system will play an important role in reducing fuel consumption and engine-out emissions in the next few decades. Compared to the pure electric and full hybrid concept, 48 V mild hybridisation and the accompanying 48 V e-boosting concept, due to their superior cost–benefit performance, may become mainstream for the next generation of fuel reduction measures. The mild hybrid system can realise advanced stop–start, active and passive engine-off coasting, braking recuperation, boost assistance, e-creeping and torque vectoring functions, and is thus deemed to give approximately 10–15% fuel consumption benefits in the New European Driving Cycle (NEDC); and the e-boosting concept, due to its capability for further downsizing and down-speeding, allows the engine operating points to be shifted into a more efficient area. A strong synergy between 48 V mild hybridisation and the 48 V e-boosting concept has been found after reviewing both technologies, and the trends for developing such a combined electrical system are also discussed. Together with more engine and vehicle component electrification, fuel efficiency could be further improved, although the interactions between these technologies are highly complex and need to be optimised at a system level.
An Outline of the Log Minimal Model Program for the Moduli Space of Curves

ABSTRACT We consider the log minimal model program for the moduli space of stable curves. It is widely believed now that there is a descending sequence of critical $α$ values where the log canonical model for the moduli space of stable curves with respect to $αδ$ changes, where $δ$ denotes the divisor of singular curves. We derive a conjectural formula for the critical values in two different ways: By working out the intersection theory of the moduli space of hyperelliptic curves and by computing the GIT stability of certain curves with tails and bridges. The results give a rough outline of how the log minimal model program would proceed, predicting when the log canonical model changes and which curves are to be discarded and acquired at the critical steps.
Asymmetric loading on the energy saving scheme for EPON networks

We study the impact of asymmetric loading on the power saving performance of EPON networks. It is generally observed that asymmetric loading often leads to reduced network performance compared to that from symmetric loading. For such network, an adaptive bandwidth assignment scheme according for traffic load can be set to meet the target of delay performance or power saving effect.
Federated filter with strengthened FDIR capability for multiple sensor navigation system

A specific integrated navigation system, INS/GPS/Doppler/CNS was analyzed. The characteristic, model and principle of federated filtering algorithm with FDIR (fault detect/isolate/rescale) capability were researched to satisfy requests of high reliability and fault-tolerant ability which were put forward by multiple sensor navigation system. Moreover, application model and FDIR model were proposed for fusion system which are built-up by local systems and supervised by federated filter. Based on these two models, local multiple fading fault-tolerant filter and FDIR strategy for general system are presented. Effectiveness and practicability rise after the validation by simulations for this two-stage (local(s)+general) fault-tolerant multiple sensor fusion system
Finger pressure adjustments to various object configurations during precision grip in humans and monkeys

In this study, we recorded the pressure exerted onto an object by the index finger and the thumb of the preferred hand of 18 human subjects and either hand of two macaque monkeys during a precision grasping task. The to‐be‐grasped object was a custom‐made device composed by two plates which could be variably oriented by a motorized system while keeping constant the size and thus grip dimension. The to‐be‐grasped plates were covered by an array of capacitive sensors to measure specific features of finger adaptation, namely pressure intensity and centroid location and displacement. Kinematic measurements demonstrated that for human subjects and for monkeys, different plate configurations did not affect wrist velocity and grip aperture during the reaching phase. Consistently, at the instant of fingers‐plates contact, pressure centroids were clustered around the same point for all handle configurations. However, small pressure centroid displacements were specifically adopted for each configuration, indicating that both humans and monkeys can display finger adaptation during precision grip. Moreover, humans applied stronger thumb pressure intensity, performed less centroid displacement and required reduced adjustment time, as compared to monkeys. These pressure patterns remain similar when different load forces were required to pull the handle, as ascertained by additional measurements in humans. The present findings indicate that, although humans and monkeys share common features in motor control of grasping, they differ in the adjustment of fingertip pressure, probably because of skill and/or morphology divergences. Such a precision grip device may form the groundwork for future studies on prehension mechanisms.
Tympanometry. ASHA Working Group on Aural Acoustic-Immittance Measurements Committee on Audiologic Evaluation.

Most of the available tympanometric data have been generated with instruments that measure immittance magnitude at 226 Hz. These limited measurements are valuable in evaluating middle-ear pathologies such as effusion and tympanic-membrane perforations but are not always adequate in evaluating pathologies of the ossicular chain such as otosclerosis and ossicular discontinuity. In response to this shortcoming, manufacturers of the newest generation of immittance devices have incorporated variable frequency or click probe signals. With these new instruments, it is possible to evaluate the middle-ear transmission system over its normal range of functioning. These new instruments also are computer based. If two-component, multifrequency immittance measurements are input to the computer, it then becomes possible to analyze and plot the data in many forms. Presently, the technology has outpaced the clinical understanding of these complex measures. The intent of this tutorial was to focus on areas of tympanometry not widely discussed in previous writings. The first two sections on terminology and instrumentation encourage clinicians to know their instruments and to use standardized terminology in communicating data. Much of the remaining information focused on the new generation of multifrequency immittance systems. Examples of normal and pathological tympanograms were plotted at a number of frequencies and in a variety of formats. In the beginning, tympanometric measures will be cumbersome, but as research begins to focus on these new measurements, the best frequency range and frequency interval and the best plotting formats will be identified. In conducting these studies, the procedural (e.g., rate and direction of ear-canal pressure change and the number of successive tympanometric runs) and computational (calculation at peak or 0 daPa and calculation of ear-canal contributions) variables must be specified if the data are to be universally applicable. Once these questions are answered, tympanometric measures with computer-based instruments will be rapid and informative. Enough data do not yet exist to incorporate multiple-frequency tympanometry into screening programs. Future research will need to address the efficacy of more complex tympanometric screening procedures. It is possible that the 226-Hz screening procedure will prove most efficient in school-aged children, the majority of whom whould be identified as having middle-ear effusion by the present procedure, or in the case of ossicular-chain abnormality, would have a significant hearing loss. (ABSTRACT TRUNCATED AT 400 WORDS)
Acting out and unusual behavior in schizophrenia.

Typical schizophrenic acting out, sometimes bizarre, is connected with special cognitive processes such as active concretization, delusional thinking, hallucinations. The patient is still capable of conceiving abstract ideation but cannot sustain it; it is too anxiety-provoking. Immediately it is transformed into concrete representations or activities. The patient must be made to realize that the therapist shares his anxiety and thereby diminishes his burden.