Miracle-dz/UniFAR-FTUs huggingface dataset:
Remote Drawing on Vertical Surfaces with a Self-Actuated Display

Today, most digital devices are either stationary, often placed on horizontal surfaces like tables, or socalled mobile devices which are carried around by the user. In this demonstration we showcase our ongoing work on a novel type of self-actuated display. It can be placed on walls, or whiteboards and other arbitrarily oriented surfaces like ceilings. It is equipped with a whiteboard marker which allows the device to draw on surfaces it is attached to. In this work, we demonstrate the device's capabilities using an interactive scenario in which users are able to remotely control the self-actuated display to draw lines on a whiteboard. They control the device either by using their own smart phone or a provided tablet computer.
Base deficit stratifies mortality and determines therapy.

OBJECTIVE To determine the association of base deficit with mortality and other factors affecting mortality. DESIGN Retrospective review. SETTING Tertiary care center. PARTICIPANTS Consecutive samples of 3791 trauma patients admitted with an arterial blood gas sample taken in the first 24 hours. MAIN OUTCOME MEASURES Age, injury mechanism, head injury, shock (systolic blood pressure less than 90 mm Hg), Revised Trauma Score, TRISS probability of survival Ps, and mortality. RESULTS Most (3038) patients (80.1%) exhibited a base deficit. Base deficit, age, injury mechanism, and head injury were associated with mortality using logistic regression. Age less than 55 years, no head injury, and a base deficit of -15 mmol/L were associated with 25% mortality. Age greater than or equal to 55 years with no head injury or age less than 55 years with a head injury and a base deficit of -8 mmol/L were associated with a 25% mortality. When shock was added to the model, all factors remained significant, and base deficit was supplemental to blood pressure. Base deficit also added significantly to the Revised Trauma Score and TRISS measurements. CONCLUSIONS The base deficit is an expedient and sensitive measure of both the degree and the duration of inadequate perfusion. It is useful as a clinical tool and enhances the predictive ability of both the Revised Trauma Score and TRISS.
The HOXD8 Locus (2q31) is Linked to Type I Diabetes: Interaction with Chromosome 6 and 11 Disease Susceptibility Genes

Type I diabetes susceptibility genes have been identified within the major histocompatibility complex (MHC) on chromosome 6p21.3 and near the VNTR/insulin region on chromosome 11p15.5. We have used polymorphic dinucleotide repeat markers to search the human genome for additional susceptibility genes in 162 type I diabetic families with an affected sibling pair. We report that an additional susceptibility gene is located on chromosome 2q31 near HOXD8 (P < 10−5, maximum logarithm of odds score = 4.8) in an analysis of affected sibling pairs having specific human leukocyte antigen (HLA) and hypervariable nucleotide tandem repeat (VNTR)/insulin gene haplotypes (absence of high-risk HLA-DR3/4 haplotypes and presence of homozygous high-risk class I VNTR alleles). These results suggest the interaction of a minimum of three genes in the pathogenesis of type I diabetes in humans.
Golgi-localizing, γ-Adaptin Ear Homology Domain, ADP-ribosylation Factor-binding (GGA) Proteins Interact with Acidic Dileucine Sequences within the Cytoplasmic Domains of Sorting Receptors through Their Vps27p/Hrs/STAM (VHS) Domains*

GGA (Golgi-localizing,γ-adaptin ear homology domain, ARF-binding) proteins are potential effectors of ADP-ribosylation factors, are associated with the trans-Golgi network (TGN), and are involved in protein transport from this compartment. By yeast two-hybrid screening and subsequent two-hybrid and pull-down analyses, we have shown that GGA proteins, through their VHS (Vps27p/Hrs/STAM) domains, interact with acidic dileucine sequences found in the cytoplasmic domains of TGN-localized sorting receptors such as sortilin and mannose 6-phosphate receptor. A mutational analysis has revealed that a leucine pair and a cluster of acidic residues adjacent to the pair are mainly responsible for the interaction. A chimeric receptor with the sortilin cytoplasmic domain localizes to the TGN, whereas the chimeric receptor with a mutation at the leucine pair or the acidic cluster is mislocalized to punctate structures reminiscent of early endosomes. These results indicate that GGA proteins regulate the localization to or exit from the TGN of the sorting receptors.
[Detection of mutation in NAT II gene as a method of determination of izoniazyd (INH) acetylation type in human population].

INTRODUCTION Isoniazid (INH) is a drug widely used in the treatment of tuberculosis. INH is metabolized to acetylisoniazid by N-acetyltransferase (NAT) in the liver. The rate of INH acetylation is genetically determined. NAT isozymes are encoded at 2 loci; one encodes NAT1, formerly known as the monomorphic form of the enzyme, while the other encodes the polymorphic NAT2, which is responsible for individual differences in the ability to acetylate certain compounds. The objective of the present study was to apply the genotyping of the fast and slow acetylators for personalized therapeutic dose. MATERIAL AND METHODS Plasma concentrations of INH were determined with biological method in the authors modification. This method warrants high accuracy and secured repeatable results. Genomic DNA was isolated from the blood samples. DNA extracted by Blood DNA Kit and amplified by PCR by Spurr [1] with two primers. PCR product was cut separately with 4 different restriction enzymes: Dde1, Kpn1, Tag1, and BamH1. RESULTS Four different NAT 2 alleles were detected in the study population. The presence of any 2 mutant alleles defines the slow-acetylator genotype, whereas rapid acetylators have 1 or 2 wild-type NAT2*4 alleles. CONCLUSION On the basis of our results we suggest the using of NAT 2 genotyping for discrimination of the fast and slow acetylators in monitoring of tuberculosis therapy.
Security in Pervasive Environments, What's Next?

A molding process for forming a three-dimensional article in layers. In one embodiment, a matrix comprising a planar grid-like member having a plurality of openings formed therethrough is employed. In an initial layer, casting material and mold material are deposited in selected openings to form a portion of the article in that layer with the casting material surrounded by the mold material. The matrix is located sequentially in adjacent layers and in each layer, the selective deposition of casting and mold material is repeated whereby the article is formed layer by layer from the casting material held in place by the mold material. The casting material is solidified and the mold material is removed. In another embodiment, planar layers of material are sequentially deposited. In each layer, prior to the deposition of the next layer, a portion of its area is solidified to define that portion of the article in that layer. Selective solidification of each layer may be accomplished by using heat and a selected mask or by using a controlled heat scanning process.
Handwritten online character recognition for single stroke Kannada characters

The objective of the work is to develop a database for Online Handwritten Kannada Characters and recognize single stroke Online Handwritten Kannada Characters (OHKC). The iball 5540U Pen Tablet is used to collect the handwritten character samples and to build the database. These samples are collected from people who are native to Kannada language. These samples are pre-processed and features are extracted. The preprocessing techniques include smoothing, resampling and normalization. The features such as normalized coordinates, normalized trajectory, normalized deviation is extracted. The recognition is carried out by K Nearest Neighbor (KNN) classifier and obtained average recognition rate of 66.08 and 73.47% for K=1 and K=3 respectively. Online handwriting recognition has wide applications such as form filling, word processing and signature verification.
Knowledge Management: An Integrated Approach

Knowledge management encompasses all aspects of managing a company’s intellectual capital, from filing, to intranets, to team briefings. It “promotes a collaborative and integrative approach to the creation, capture, organisation, access and use of information assets” (European Centre for Customer Strategies). In the past firms have approached KM as a well-defined function, or task to be completed. In fact it is simply a way of working, which recognises the importance of using existing and current knowledge. Once adopted, this method of operating should gradually become invisibly embedded into a company’s strategy and culture.
Experimental short-term tolerance to perfluorodecalin in the rabbit eye: a histopathological study.

PURPOSE Perfluorocarbon liquids are largely used in vitreoretinal surgery, but their permanence into the eye is considered harmful and early withdrawal is routinely performed by most of the surgeons. We undertook this investigation to evaluate the effects of Perfluorodecalin (PFD) tamponade following vitrectomy in the rabbit eye. METHODS Twenty-four rabbits underwent vitrectomy of the right eye according with a standard procedure. Eighteen rabbits received PFD and 6 control rabbits received Balanced Salt Solution (BSS) as vitreous substitute. The eyes were examined with light microscopy and transmission electron microscopy after two, four and six days after tamponade and thirty days after the withdrawal of PFD. RESULTS The tamponade lasting four or more days caused irreversible retinal damage involving the photoreceptors and retinal pigment epithelium. Peculiar impressions were formed in the inner retina at the site of the gravitational effect of PFD droplets. CONCLUSIONS Based on the results of this study we suggest that the tamponade with PFD lasting more than two days is detrimental to the retina, at least in the case of the rabbit. Damage seems to be related only to the high specific gravity of PFD.
Comparison of 10 nm GAA vs. FinFET 6-T SRAM performance and yield

This work benchmarks the performance of GAA MOSFETs against that of optimized SOI FinFETs at 10 nm gate length. The yield of 6-T SRAM cells implemented with these advanced MOSFET structures is then investigated. GAA MOSFET technology is projected to provide for 0.1 V lower minimum cell operating voltage with reduced cell area.
Breast Conserving Treatment in Early Breast Cancer: Impact of Local Recurrence Pattern on Patient Survival

To the Editor: Breast conserving therapy (BCT) has been considered the current standard care for early breast cancer treatment (1,2). With the widely used conservative surgery for breast cancer, an increasing number of local regional recurrence (LRR) has been diagnosed. The clinical course after local recurrence varies greatly. A considerable number of patients can be treated with savage mastectomy (3). However, some studies have shown that breast tumor recurrence is a predictor of distant metastases implying poor prognosis (4,5). To investigate the impact of local recurrence on patient prognosis, we developed this study. A retrospective study including 192 patients with early stage breast cancer subjected to BCT was performed to evaluate the local recurrence pattern and its role in disease progression. According to clinical and pathological criteria (time to recurrence, site of local recurrence, and histological type), we classified patients as true local recurrence (TR group), new primary tumor (NP group), and patients free of local recurrence (FLR group). Comparing the clinical course among these groups, we observed that patients classified as NP are associated with young age and premenopausal status and the presence of TR is the most important predictive factor of prognosis. Synchronic metastatic disease was observed in 40% of patients in TR group. On the other hand, the metastatic disease occurred in 28.5% and 4.7% of patients in the NP and FLR groups, respectively (p < 0.0001). The mean survival time was 43.7 months in the TR group, 112.6 months in the NP group and 105.9 months in the FLR group (p < 0.0001). Histological type and grade, margins status, lymph node metastasis and hormonal receptors were not predictive factors of local recurrence. Patients who did not undergo hormonal therapy and of young age are the most important predictive factors of local recurrence. We could not observe a relationship between inappropriate clear margin resection and the local recurrence. True local recurrence had an influence on overall survival in patients with early breast cancer treated with breast conserving surgery and the main risk factors for local recurrence were young age. According to our data, we assumed that, in patients who experience local recurrence, the definition between a new primary and a true recurrence using clinical and pathological criteria plays a crucial role in salvage therapy.
Radiofrequency Catheter Ablation of a Macroreentrant Ventricular Tachycardia Late After Surgical Repair of Tetralogy of Fallot Using the Electroanatomic Mapping (CARTO)

This case report describes a patient with a sustained monomorphic VT after surgical repair of a tetralogy of Fallot (TOF). In combination with the three‐dimensional electroanatomic mapping system, CARTO, and conventional mapping techniques the VT was identified as a macro‐reentrant tachycardia circling around the border between pulmonary graft and right ventricular outflow tract (RVOT). A y‐shaped ablation line crossing this zone was created. The VT terminated during RF application and was not inducible again. This case underlines the use of a combined conventional and three‐dimensional electroanatomic mapping technique can be helpful for catheter ablation of ventricular arrhythmias in TOF patients. (PACE 2004; 27[Pt. I]:801–804)
Design and analysis of a double band hysteresis SMC for cascaded inverter-based PV system

This paper presents a sliding mode controller (SMC) for a cascaded two-level inverter (CTLI)-based grid connected/ stand-alone photovoltaic (PV) system with double-band hysteresis scheme. The nonlinear SMC based PV system has been designed to inject the desired amount of active power even with variable solar irradiance and load change. The proposed topology employs PV module driven cascaded two-level inverter, connected the grid/load, through an open winding three-phase transformer. The controller is developed keeping the maximum power delivery of the PV in consideration. The performance of the proposed controller has been improved by using an adaptive hysteresis band calculation. The proposed control of the CTLI based PV system is implemented in MATLAB/Simulink, for both steady state and dynamic conditions. The results verify the effectiveness of the transient and steady state operation of the proposed control strategy. Moreover, the SMC is found capable of keeping the switching frequency at the designed value almost accurately.
Scanning Tunneling Microscopic Study with Atomic Resolution of the Dissolution of Cu(111) in Aqueous Chloride Solutions

In situ scanning tunneling microscopy (STM) of the dissolution of a Cu( 1 1 1 ) electrode in aqueous chloride media (HC1 and KCl) was employed to ascertain the mechanism of the reaction at the atomic level. At potentials where there was no dissolution, atomic imaging of the Cu( 1 1 1 ) revealed a ( 6 4 3 x 6d3)R30° structure consisting of a C1 adlattice with a C1-C1 distance of 0.39 f 0.02 nm which is in agreement with vacuum surface analytical (low-energy electron diffraction, Auger electron analysis and STM) studies of Cu( 1 1 1 ) dosed with chlorine and aqueous C1-. Imaging at potentials where the anodic dissolution of Cu begins reveals that the preferred reaction sites were step edges, and the retreating edges always ran along steps in the (211) direction. Rates of dissolution increased as the potential was increased, with the predominant reaction site being step edges. The dissolution rate was higher in the presence of K+.
LOCH: supporting mobile language learning outside classrooms

This paper describes a Computer-Supported Mobile Learning (CSML) environment for language learning, called Language-learning Outside the Classroom with Handhelds (LOCH). In the environment, the teacher assigns field activities to the students, who go around the town to fulfil them and share their individual knowledge and experiences. The main aim of this project, called One-Day Trip with PDA, was to integrate the knowledge acquired in the classroom and the real needs of the students in their daily life. This paper also presents the evaluation by five different groups of foreign students for the past three years.
Mutations in the Yellow Fever Virus Nonstructural Protein NS2A Selectively Block Production of Infectious Particles

ABSTRACT Little is known about the function of flavivirus nonstructural protein NS2A. Two forms of NS2A are found in yellow fever virus-infected cells. Full-length NS2A (224 amino acids) is the product of cleavage at the NS1/2A and NS2A/2B sites. NS2Aα, a C-terminally truncated form of 190 amino acids, results from partial cleavage by the viral NS2B-3 serine protease at the sequence QK↓T within NS2A. Exchange of serine for lysine at this site (QKT→QST) blocks the production of both NS2Aα and infectious virus. The present study reveals that this defect is not at the level of RNA replication. Despite normal structural region processing, infectious particles containing genome RNA and capsid protein were not released from cells transfected with the mutant RNA. Nevertheless, production of subviral prM/M- and E-containing particles was unimpaired. The NS2A defect could be complemented in trans by providing NS1-2A or NS1-2Aα. However, trans complementation was not observed when the C-terminal lysine of NS1-2Aα was replaced with serine. In addition to true reversions, NS2Aα cleavage site mutations could be suppressed by two classes of second-site changes. The first class consisted of insertions at the NS2Aα cleavage site that restored its basic character and cleavability. A second class of suppressors occurred in the NS3 helicase domain, in which NS3 aspartate 343 was replaced with an uncharged residue (either valine, alanine, or glycine). These mutations in NS3 restored infectious-virus production in the absence of cleavage at the mutant NS2Aα site. Taken together, our results reveal an unexpected role for NS2A and NS3 in the assembly and/or release of infectious flavivirus particles.
Screening for Language Delay: Growth Trajectories of Language Ability in Low- and High-Performing Children.

Purpose This study investigated the stability and growth of preschool language skills and explores latent class analysis as an approach for identifying children at risk of language impairment. Method The authors present data from a large-scale 2-year longitudinal study, in which 600 children were assessed with a language-screening tool (LANGUAGE4) at age 4 years. A subsample (n = 206) was assessed on measures of sentence repetition, vocabulary, and grammatical knowledge at ages 4, 5, and 6 years. Results A global latent language factor showed a high degree of longitudinal stability in children between the ages of 4 to 6 years. A low-performing group showing a language deficit compared to their age peers at age 4 was identified on the basis of the LANGUAGE4. The growth-rates during this 2-year time period were parallel for the low-performing and 3 higher performing groups of children. Conclusions There is strong stability in children's language skills between the ages of 4 and 6 years. The results demonstrate that a simple language screening measure can successfully identify a low-performing group of children who show persistent language weaknesses between the ages of 4 and 6 years.
Similarity Evalution between Graphs: A Formal Concept Analysis Approach

Many real-world applications information are organized and represented with graph structure which is often used for representing various ubiquitous networks, such as World Wide Web, social networks, and proteinprotein interactive networks. In particular, similarity evaluation between graphs is a challenging issue in many fields such as graph searching, pattern discovery, neuroscience, chemical compounds exploration and so forth. There exist some algorithms which are based on vertices or edges properties, are proposed for addressing this issue. However, these algorithms do not take both vertices and edges similarities into account. Towards this end, this paper pioneers a novel approach for similarity evaluation between graphs based on formal concept analysis. The feature of this approach is able to characterize the relationships between nodes and further reveal the similarity between graphs. Therefore, the highlight of our approach is to take vertices and edges into account simultaneously. The proposed algorithm is evaluated using a case study for validating the effectiveness of the proposed approach on detecting and measuring the similarity between graphs.
Helping effort and future fitness in cooperative animal societies

Little attention has been paid to a conspicuous and universal feature of animal societies: the variation between individuals in helping effort. Here, we develop a multiplayer kin–selection model that assumes that subordinates face a trade–off because current investment in help reduces their own future reproductive success. The model makes two predictions: (i) subordinates will work less hard the closer they are to inheriting breeding status; and (ii) for a given dominance rank, subordinates will work less hard in larger groups. The second prediction reflects the larger pay–off from inheriting a larger group. Both predictions were tested through a field experiment on the paper wasp Polistes dominulus. First, we measured an index of helping effort among subordinates, then we removed successive dominants to reveal the inheritance ranks of the subordinates: their positions in the queue to inherit dominance. We found that both inheritance rank and group size had significant effects on helping effort, in the manner predicted by our model. The close match between our theoretical and empirical results suggests that individuals adjust their helping effort according to their expected future reproductive success. This relationship has probably remained hidden in previous studies that have focused on variation in genetic relatedness.
Collaborative information searching as learning in academic group work

Purpose This paper aims to explore users’ learning in the collaborative information search process when they conduct an academic task as a group. Design/methodology/approach This paper presents a longitudinal study on a three-month period on an actual task. The participants, who were undergraduate students, needed to write a research proposal in three months to apply for funding for a research project, including a three-hour experiment. Findings The results show that undergraduates’ learning in the collaborative search process for academic group work included knowledge reconstruction, tuning, and assimilation. Their understanding of the topic concepts improved through the process, and their attitudes became more optimistic. Besides, the learning in the collaborative information search process also enhanced participants’ skills in communication, research, information search, and collaboration. To improve learning outcomes, professional and appropriate academic resources are required, as well as effective d.
A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes

A recombinant vaccinia has been designed to express amino acids 366-379 of influenza nucleoprotein, previously shown to be the minimal epitope recognized by a class I-restricted cytotoxic T cell clone. Target cells infected with the recombinant vaccinia virus expressing this peptide are recognized by CTL as efficiently as target cells expressing the complete nucleoprotein. The results imply the existence of a peptide transport system that constitutively passes the products of degraded proteins from the cytoplasm into a membrane-bound compartment of the cell.