Miracle-dz/UniFAR-FTUs huggingface dataset:
Desarrollo de una arquitectura orientada a servicios para un prototipo de una línea de productos de Software

Resumen. Una arquitectura orientada a servicios o SOA (Service Oriented Architecture) es una arquitectura de software que proporciona servicios que corresponden a funcionalidad de negocio reutilizable a través de interfaces bien definidas. SOA surge ante la necesidad de poder emplear funcionalidad ya disponible en sistemas heterogéneos distribuidos. Para desarrollar una SOA, existen diversas opciones tecnológicas que permiten implementar servicios web. Un servicio web permite definir componentes o servicios reutilizables que representan tareas de negocio. En este trabajo se presenta el desarrollo de una arquitectura orientada a servicios para una aplicación denominada PAAc. PAAc es el prototipo de una herramienta para registro de actividades y productos académicos que pretende servir de base para el desarrollo de una Línea de Productos de Software (LPS) y sigue un estilo Modelo Vista Controlador (MVC). Dadas las ventajas que ofrece SOA, se decide implementar este estilo arquitectónico para PAAc como una opción en la futura implementación de la mencionada LPS. Adicionalmente, es posible constatar la reutilización de la lógica de negocios de PAAc, gracias a la implementación del MVC.
IMMUNOMODULATORY ACTIVITY OF LACTOBACILLUS SPOROGENES

The present study was undertaken to explore the immunomodulatory activity of probiotic strain Lactobacillus sporogenes on total leukocyte count, differential leukocyte count, neutrophil adhesion test, humoral response to BCG vaccine, delayed-type hypersensitivity and phagocytic activity. Pre-treatment with probiotic evoked a significant increase in total leukocyte count and per-cent neutrophil and lymphocyte increase in differential leukocyte count. The probiotic strain produced a significant increase in neutrophil adhesion to nylon fibres. The augmentation of humoral immune response to BCG vaccine by Lactobacillus sporogenes (1 gm powder contains not less than 150 million spores) is evidenced by significant increase in antibody titres in rats. Oral administration of probiotic spores in rat, for a period of 28 days, significantly potentiated the delayed-type hypersensitivity reaction induced by BCG vaccine. The strain was also evaluated for in vivo phagocytic activity by carbon clearance assay in mice wherein, significant increase in the phagocytic index was observed. Thus the study stated that the probiotic strain Lactobacillus sporogenes shows a significant stimulation of the cell mediated immunity and humoral immunity.
Proteomic characterization of mouse cartilage degradation in vitro.

OBJECTIVE To develop proteomics to analyze mouse cartilage degradation and correlate transcriptional and translational responses to catabolic stimuli. METHODS Proteomic techniques were used to analyze catabolism in mouse femoral head cartilage. Using specific methods to prepare cartilage extracts and conditioned media for 2-dimensional polyacrylamide gel electrophoresis and subsequent tandem mass spectrometry, we identified novel proteins and fragments released into the media of control, interleukin-1alpha (IL-1alpha)-treated, and all-trans-retinoic acid (RetA)-treated explants. Fluorescence 2-dimensional difference gel electrophoresis was used to quantify protein expression changes. We also measured changes in messenger RNA (mRNA) expression to distinguish transcriptional and posttranslational regulation of released proteins. RESULTS Differentially abundant proteins in the media of control and treated explants included fragments of thrombospondin 1 and connective tissue growth factor. IL-1alpha stimulated release of the cartilage degeneration marker matrix metalloproteinase 3, as well as proteins with uncharacterized roles in cartilage pathology, such as neutrophil gelatinase-associated lipocalin. RetA stimulated release of the extracellular matrix proteins cartilage oligomeric matrix protein, link protein, and matrilin-3 into the media, which was accompanied by a dramatic reduction in the corresponding mRNA transcript levels. Gelsolin, which has been implicated in cytoskeletal reorganization in arthritis synovial fibroblasts but has not been previously associated with cartilage pathology, was regulated by IL-1alpha and RetA. CONCLUSION In this first analysis of mouse cartilage degradation and protein release using proteomics, we identified proteins and fragments, some of which represent novel candidate biomarkers for cartilage degradation. Applying these proteomic techniques to wild-type and genetically modified mouse cartilage will provide insights into the mechanisms of cartilage degeneration.
Novel fixed frequency predictive hysteresis maximum power point tracking control for photovoltaic applications

A novel Maximum Power Point Tracking (MPPT) control for Photovoltaic applications is proposed in this paper. The proposed control algorithm is two-stage control system. The first stage is a Modified Incremental Inductance (MIC) algorithm and the second stage is based on Fixed Frequency Predictive Hysteresis Control (FFPHC). The purpose of the MIC stage is to generate the required reference current that achieves the maximum power. And the function of the FFPHC is to force the system to track that reference. The proposed control algorithm has some inherent features such as ability to achieve maximum power even in case of rapid environmental changes, ability to achieve maximum power in case of partial shading. Operation of predictive hysteresis control at fixed frequency gives the advantages of better power stage parameters design and enables controlling the switching losses.
The illiterate brain and the neuropsychological assessment: From the past knowledge to the future new instruments

ABSTRACT The lifetime learning of illiterate and low-educated individuals shapes their cognitive skills, which are challenging to grade by the current available neuropsychological tools. Eight hundred million of the global population are illiterate. It is very challenging to interpret the cognitive performance of this population by the available formal neuropsychological tests, mainly developed for higher educated people. From extensive literature investigation, we reviewed the cognitive process and performance of illiterate and low-educated population on various cognitive domains including language, executive function, memory, visual-related function, and motor skills. We also suggested the concept in the development of the appropriate tools for the cognitive assessment among this population. Finally, we provide the available cognitive screening tools validated in the illiterate and low-educated subjects within the last three decades.
Isolation enhancement of patch antennas using metamaterial superstrate

A system integrated with multiple antenna elements suffers from the adverse effects of mutual coupling arising from the close proximity of the elements. This paper proposes a method to increase the isolation between microstrip patch antenna elements by using a metamaterial superstrate. By using this technique, it is possible to increase the isolation up to the level of 30dB at the resonant frequency with an edge to edge distance of λ 0/18.5 between the antenna elements. At the same time, the gain and efficiency of the antennas are also enhanced.
Nanowire Transistor Behavior Under AC Drives

Reliable nanowire transistors (NWTs) under ac drives are required for applications such as display pixels and driving circuits. In this study, the transistor characteristics of SnO2 NWTs by ac stress and the effects of passivation were examined to investigate the device reliability under ac drives. Under ac stress, the shift in the threshold voltage (V th) of the devices without passivation was within the range of 2-7 V, whereas the device with passivation showed positive shifts of less than ~1.6 V. The device with passivation also stabilized twice as fast as that without passivation. Heat was generated in the nanowires under ac drives, and accordingly, a passivation layer limited the temperature increase and distributed the carriers more evenly in the nanowires as compared to the nonpassivated case. These mechanisms enable the transistor characteristics to remain stable under ac drives. The stabilization was verified by simulating with a Vth model equation for metal oxide semiconductor devices and by including the temperature as a variable. The results show that NWTs with passivation exhibited stable transistor characteristics under repetitive ac stress for long durations. This research suggests improvement measures for fabricating nanowire circuits that are reliable under ac drives.
Multiclass Least Squares Twin Support Vector Machine for Pattern Classification

This paper proposes a Multiclass Least Squares Twin Support Vector Machine (MLSTSVM) classifier for multi-class classification problems. The formulation of MLSTSVM is obtained by extending the formulation of recently proposed binary Least Squares Twin Support Vector Machine (LSTSVM) classifier. For M-class classification problem, the proposed classifier seeks M-non parallel hyper-planes, one for each class, by solving M-linear equations. A regularization term is also added to improve the generalization ability. MLSTSVM works well for both linear and non-linear type of datasets. It is relatively simple and fast algorithm as compared to the other existing approaches. The performance of proposed approach has been evaluated on twelve benchmark datasets. The experimental result demonstrates the validity of proposed MLSTSVM classifier as compared to the typical multi-classifiers based on ‘Support Vector Machine’ and ‘Twin Support Vector Machine’. Statistical analysis of the proposed classifier with existing classifiers is also performed by using Friedman’s Test statistic and Nemenyi post hoc techniques.
Reliability and consistency of plantarflexor stretch-shortening cycle function using an adapted force sledge apparatus

There are various limitations to existing methods of studying plantarflexor stretch-shortening cycle (SSC) function and muscle-tendon unit (MTU) mechanics, predominantly related to measurement validity and reliability. This study utilizes an innovative adaptation to a force sledge which isolates the plantarflexors and ankle for analysis. The aim of this study was to determine the sledge loading protocol to be used, most appropriate method of data analysis and measurement reliability in a group of healthy, non-injured subjects. Twenty subjects (11 males, 9 females; age: 23.5 ±2.3 years; height: 1.73 ±0.08 m; mass: 74.2 ±11.3 kg) completed 11 impacts at five different loadings rated on a scale of perceived exertion from 1 to 5, where 5 is a loading that the subject could only complete the 11 impacts using the adapted sledge. Analysis of impacts 4–8 or 5–7 using loading 2 provided consistent results that were highly reliable (single intra-class correlation, ICC > 0.85, average ICC > 0.95) and replicated kinematics found in hopping and running. Results support use of an adapted force sledge apparatus as an ecologically valid, reliable method of investigating plantarflexor SSC function and MTU mechanics in a dynamic controlled environment.
Delivery of Neurotrophic Factors to the CNS Using Encapsulated Cells: Developing Treatments for Neurodegenerative Diseases

Protein neurotrophic factors are emerging as potential treatments for a number o f chronic neurodegenerative diseases . Del ivery o f neurotrophic factors t o the C N S stably and over the long-term is o n e o f the largest o b ­ stacles t o the deve lopment o f effective therapies for these important disorders. The chemical modif icat ion o f s o m e o f these factors m a y eventual ly prove effec­ tive, however, it remains unclear h o w readily this strat­ egy will provide new therapies . A number o f other approaches are being contemplated, including implant­ able , growth factor-secreting p u m p s , implantat ion o f genetically modif ied cell lines and in situ modif icat ion o f specific C N S cell populat ions using viral vector sys­ tems . However , all o f these approaches suffer from in­ herent inefficiency or safety issues. The encapsulat ion o f cell l ines genet ical ly modi f i ed to secrete neuro­ trophic factors and then transplanted to specific sites within the C N S m a y provide an alternative and viable approach to treating C N S diseases (3) .
A consistent test of independence based on a sign covariance related to Kendall's tau

The most popular ways to test for independence of two ordinal random variables are by means of Kendall's tau and Spearman's rho. However, such tests are not consistent, only having power for alternatives with ``monotonic'' association. In this paper, we introduce a natural extension of Kendall's tau, called $\tau^*$, which is non-negative and zero if and only if independence holds, thus leading to a consistent independence test. Furthermore, normalization gives a rank correlation which can be used as a measure of dependence, taking values between zero and one. A comparison with alternative measures of dependence for ordinal random variables is given, and it is shown that, in a well-defined sense, $\tau ^*$ is the simplest, similarly to Kendall's tau being the simplest of ordinal measures of monotone association. Simulation studies show our test compares well with the alternatives in terms of average $p$-values.
Intermittent release of transients in the slow solar wind: 1. Remote sensing observations

[1] The Heliospheric Imager (HI) instruments on board the STEREO spacecraft are used to analyze the solar wind during August and September 2007. We show how HI can be used to image the streamer belt and, in particular, the variability of the slow solar wind which originates inside and in the vicinity of the streamer belt. Intermittent mass flows are observed in HI difference images, streaming out along the extension of helmet streamers. These flows can appear very differently in images: plasma distributed on twisted flux ropes, V-shaped structures, or “blobs. ” The variety of these transient features may highlight the richness of phenomena that could occur near helmet streamers: emergence of flux ropes, reconnection of magnetic field lines at the tip of helmet streamers, or disconnection of open magnetic field lines. The plasma released with these transient events forms part of the solar wind in the higher corona; HI observations show that these transients are frequently entrained by corotating interaction regions (CIRs), leading to the formation of larger, brighter plasma structures in HI images. This entrainment is used to estimate the trajectory of these plasma ejecta. In doing so, we demonstrate that successive transients can be entrained by the same CIR in the high corona if they emanate from the same corotating source. Some parts of the streamers are more effective sources of transients than others. Surprisingly, evidence is given for the outflow of a recurring twisted magnetic structure, suggesting that the emergence of flux ropes can be recurrent.
Combined bone grafting and delayed closure of the hard palate in patients with unilateral cleft lip and palate: facilitation of lateral incisor eruption and evaluation of indicators for timing of the procedure.

OBJECTIVE To compare outcomes of bone grafting performed before eruption of the lateral incisor to outcomes of grafting performed before eruption of the canine and to evaluate the long-term results of bone grafting combined with delayed closure of the hard palate during mixed dentition. DESIGN Seventy consecutive patients (52 men and 18 women) with complete unilateral cleft lip and palate were studied. All patients underwent bone grafting with simultaneous closure of the cleft in the hard palate at the stage of mixed dentition. The velum had been repaired in infancy. Mean age for the bone grafting procedure was 8.4 years. Bone grafting was performed to facilitate eruption of the lateral incisor in 43 (61%) of the patients and to facilitate eruption of the canine in the remaining 27 (39%) patients. Intraoral radiographs were used to evaluate the morphologic characteristics of the cleft and the stage of eruption of the permanent lateral incisor and canine before bone grafting. Mean follow-up time was 4.0 years (range, 1-10.1 years). RESULTS The mean time for the surgery, which included bone grafting and repair of the residual cleft in the hard palate, was 109 minutes, and the mean amount of bleeding was 121 ml. The rate of dehiscence in the flap covering the alveolar bone graft was 14%, and the rate of total failure of bone grafting was 3%. An oronasal fistula developed in the hard palate of 13% of patients, but the fistula was of sufficient size to serve as an indication for reoperation in only 6%. The postoperative alveolar bony height in the cleft area was more than 75% of the normal height in 94% of patients. Closure of the cleft space in the dental arch was performed or planned to be achieved orthodontically in 91% of patients. When bone grafting was performed to facilitate eruption of the lateral incisor, the cleft space was closed orthodontically in 100% of patients. The optimal indicator for timing of the bone grafting procedure from an orthodontic point of view was when the permanent lateral incisor or the canine close to the cleft was covered by a thin shell of bone (i.e., 7-9 years of age).
The Association Between Triple X and Psychosis

Two cases of psychotic illness in association with the karyotype triple X showed specific diagnostic and management problems as well as obstetric complications, EEG abnormalities, and lack of a family history of psychiatric disorder. Routine karyotyping during the investigation of psychosis is becoming relevant to psychiatric practice as research reports increasingly feature genetic and chromosome anomalies in association with schizophrenic psychoses. British Journal of Psychiatry (1992), 160, 554–557
An image-guided magnetic resonance-compatible surgical robot.

OBJECTIVE The past decade has witnessed the increasing application of robotics in surgery, yet there is no existing system that combines stereotaxy and microsurgery in an imaging environment. To fulfill this niche, we have designed and manufactured an image-guided robotic system that is compatible with magnetic resonance imaging. METHODS The system conveys the sight, touch, and sound of surgery to an operator seated at a remote workstation. Motion scaling, tremor filtering, and precision robotics allow surgeons to rapidly attain technical proficiency while working at a spatial resolution of 50 to 100 microm instead of a few millimeters. This system has the potential to shift surgery from the organ toward the cellular level. RESULTS By integrating the robot with images obtained during the procedure, the effects of surgery on both the lesion and brain are immediately revealed. CONCLUSION We are providing technology to advance and transform surgery with the potential to improve patient outcome.
Cytochrome P-450cam. III. Removal and replacement of ferriprotoporphyrin IX.

Abstract Apocytochrome P-450cam in a reconstitutable form was prepared from the purified native holoenzyme by acid-acetone treatment at -20°. The prosthetic group is ferriprotoporphyrin IX, identified by the pyridine hemochromogen spectrum and by co-chromatography of authentic and isolated samples. The apocytochrome is not protected by the substrate and is less stable at -20°. The catalytically active holocytochrome P-450cam has been prepared from the apoenzyme in greater than 66% yield via P-420 on addition of equimolar heme in 4% methanol-phosphate buffer, pH 7.0, followed by a cysteine-glycerol treatment.
The neuronal architecture of the cochlear nucleus of the cat

A detailed parcellation of the entire cochlear nucleus of the cat was prepared with the Nissl and Protargol methods in the form of a cytoarchitectonic atlas. Neuronal cell types were characterized in rapid Golgi impregnations. Golgi impregnations were used to define the specific features of the mature neuronal types. Neurons from the Golgi preparations were systematically mapped according to type and location in serial sections. These neurons were then plotted in corresponding positions in the cytoarchitectonic atlas. This combined Golgi‐Nissl approach provides a scheme in which neuronal types, defined in terms of a number of functionally significant features, can be precisely localized within the cochlear nucleus.
DNA polymerase lambda directly binds to proliferating cell nuclear antigen through its confined C‐terminal region

DNA polymerase lambda (Pol λ) was recently identified as a new member of the family X of DNA polymerases. Here, we show that Pol λ directly binds to proliferating cell nuclear antigen (PCNA), an auxiliary protein for DNA replication and repair enzymes, both in vitro and in vivo. A pull‐down assay using deletion mutants of Pol λ showed that the confined C‐terminal region of Pol λ directly binds to PCNA. Furthermore, a synthetic peptide of 20‐mers derived from the C‐terminal region of Pol λ competes with full‐length Pol λ for binding to PCNA. The residues between amino acids 518 and 537 of Pol λ are required for binding to PCNA, and are different from the consensus PCNA interacting motif (PIM). Pol λ associates with PCNA in vivo by immunoprecipitation analysis and EGFP‐tagged Pol λ co‐localizes with PCNA as spots within a nucleus using fluorescent microscopy. Through direct binding, PCNA suppressed the distributive nucleotidyltransferase activity of Pol λ. Pol µ, which also belongs to the family X of DNA polymerases, binds to PCNA by a pivotal amino acid residue.
Design, analysis and fabrication of a brush-less DC motor

This paper presents detailed steps and procedure for the design of a permanent magnet brush-less DC machine(PM-BLDC). Here the design(both the armature circuit and the PM field) is done for a 4-pole 0.75 hp, 1500 rpm surface mounted BLDC(SPM-BLDC). First the design and the performance analysis of the machine has been done by hand calculation. The results are then fine tuned and verified using a standard finite element analysis(FEM) software. Parameters of the machine have also been calculated. The designed BLDC motor also have been fabricated.
Loss of GATA6 Leads to Nuclear Deformation and Aneuploidy in Ovarian Cancer

ABSTRACT A prominent hallmark of most human cancer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas. The developmentally regulated GATA6 transcription factor is commonly lost in ovarian cancer, and the loss of its expression is closely associated with neoplastic transformation of the ovarian surface epithelium. In the present study, we found that reduction of GATA6 expression with small interfering RNA (siRNA) in human ovarian surface epithelial cells resulted in deformation of the nuclear envelope, failure of cytokinesis, and formation of polyploid and aneuploid cells. We further discovered that loss of the nuclear envelope protein emerin may mediate the consequences of GATA6 suppression. The nuclear phenotypes were reproduced by direct suppression of emerin with siRNA. Thus, we conclude that diminished expression of GATA6 leads to a compromised nuclear envelope that is causal for polyploidy and aneuploidy in ovarian tumorigenesis. The loss of emerin may be the basis of nuclear morphological deformation and subsequently the cause of aneuploidy in ovarian cancer cells.