Miracle-dz/UniFAR-FTUs huggingface dataset:
Fatores de influencia no desgaste de matrizes de forjamento a quente de bielas automotivas

Uma faixa significativa do preco final de produtos forjados e proveniente de custos referentes a re-trabalho de ferramental devido a falhas superficiais nas matrizes de conformacao. Na busca de uma empresa por maior competitividade em termos de preco e tempo, surge a necessidade de entender-se os mecanismos de falha das matrizes de modo a aumentar sua vida util, evitando situacoes de risco para a matriz e uma possivel falha, diminuindo custos referentes ao re-trabalho e diminuindo tempos de manutencao e set-ups, tendo por fim um aumento de produtividade. Alem de mudancas conhecidas para o aumento da vida util das matrizes como, por exemplo, temperatura e velocidade de forjamento, lubrificacao e alteracoes metalurgicas superficiais nas matrizes, pode-se aumentar a vida util das matrizes com mudancas geometricas do desenho do forjado. Neste trabalho foi estudado como a modificacao dos valores do raio de boca, largura do patamar de rebarba, maior profundidade de cavidade, raio superior da haste, espessura de rebarba e temperaturas de forjamento e de matrizes influenciam no processo de desgaste de matrizes de pre-forma no forjamento de bielas automotivas na regiao da haste. Atraves de simulacao numerica e analise estatistica pode-se verificar que os parâmetros que mais influem no processo de desgaste sao os mesmos que influem na profundidade de cavidade de matriz que por sua vez influem diretamente na largura total de rebarba que escoa pelo patamar de rebarba, sendo assim a largura de rebarba uma medida comparativa do desgaste. Foi analisado tambem o processo de forjamento na regiao da haste de bielas, podendo-se verificar quatro etapas distintas para a evolucao do desgaste, da tensao normal e do carregamento. Nessa avaliacao verificou-se que o processo de escoamento durante o forjamento difere do observado em referencias bibliograficas disponiveis, podendo-se verificar um processo de recalque na haste ou de escoamento radial das cabecas do laminado em direcao a haste, o que tende a aumentar o diâmetro do tarugo que por sua vez com diâmetros maiores da haste, aumentam tambem o processo de desgaste, portanto sendo um importante fator a ser considerado em projetos de bielas. Da analise dos graficos da forca necessaria para forjar a regiao da haste pode-se verificar tambem que a curva grafica de carregamento se distingue quando ha falha de preenchimento de cavidade quando comparado com um processo sem falha. Por fim atraves da construcao de graficos de mapeamento do processo ou sobre-posicao de graficos de contorno para os parâmetros com os quais houve falha de preenchimento para o desgaste e carregamento, podem-se verificar regioes otimizadas, sem falhas, com menores valores de desgaste, com aumento da vida util das matrizes, garantia de qualidade do produto e possivelmente, reducao de materia-prima. Abstract
Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity*

SIRT1 is involved in the pathogenesis of obesity, diabetes, and aging. However, it is not clear how SIRT1 activity is regulated by intracellular kinases in cells. In this study, we investigated SIRT1 phosphorylation and protein degradation in response to JNK1 activation in obese mice. Mouse SIRT1 is phosphorylated by JNK1 at Ser-46 (Ser-47 in human SIRT1), which is one of the four potential residues targeted by JNK1. The phosphorylation induces a brief activation of SIRT1 function and degradation of SIRT1 thereafter by the proteasome. Ubiquitination occurs in SIRT1 protein after the phosphorylation. Mutation of Ser-46 to alanine prevents the phosphorylation, ubiquitination, and degradation. In vivo, SIRT1 undergoes an extensive degradation in hepatocytes in obesity as a consequence of persistent activation of JNK1. The degradation leads to inhibition of SIRT1 function, which contributes to development of hepatic steatosis. The degradation disappears in obesity when JNK1 is inactivated in mice. JNK2 exhibits an opposite activity in the regulation of SIRT1 degradation. The JNK1-SIRT1 pathway provides a new molecular mechanism for the pathogenesis of hepatic steatosis in obesity.
La medición del bienestar a través de indicadores subjetivos: una revisión

En los ultimos anos, ha llegado a ser cada vez mas evidente la necesidad de incorporar aspectos subjetivos, como las percepciones de los individuos sobre sus condiciones de vida y las relaciones sociales que sostienen, en la evaluacion del bienestar. En este texto se entregan algunas herramientas conceptuales y metodologicas basicas para los interesados en el uso de informacion subjetiva para la medicion del bienestar, con enfasis en la discusion de los argumentos a favor o en contra de su utilizacion, y en el analisis de la calidad de los metodos empleados en la produccion de informacion sobre las percepciones de los individuos acerca de sus condiciones de vida. Con ello, se busca que los actores regionales implicados en las politicas publicas avancen en la incorporacion de la informacion subjetiva en el analisis empirico del bienestar, pero teniendo en cuenta las ventajas y desventajas de los instrumentos de medicion disponibles.
Single molecule mechanics of the kinesin neck

Structural integrity as well as mechanical stability of the parts of a molecular motor are crucial for its function. In this study, we used high-resolution force spectroscopy by atomic force microscopy to investigate the force-dependent opening kinetics of the neck coiled coil of Kinesin-1 from Drosophila melanogaster. We find that even though the overall thermodynamic stability of the neck is low, the average opening force of the coiled coil is >11 pN when stretched with pulling velocities >150 nm/s. These high unzipping forces ensure structural integrity during motor motion. The high mechanical stability is achieved through a very narrow N-terminal unfolding barrier if compared with a conventional leucine zipper. The experimentally mapped mechanical unzipping profile allows direct assignment of distinct mechanical stabilities to the different coiled-coil subunits. The coiled-coil sequence seems to be tuned in an optimal way to ensure both mechanical stability as well as motor regulation through charged residues.
The Influence of B 2 B e-Commerce on SME ’ s Performance and Efficiency : A Literature Review

Business-to-business (B2B) is the most common application of electronic commerce (EC) systems. It accounts for the largest number of transactions and sales volume of any EC system applications (Cunningham, 2002). Hoffman and Novak (2000) explore the extent of B2B adoption as Internet technology usage that provides the capacity to buy and sell online, which includes market creation, ordering, supply chain management (SCM), and money transfer through open protocols. The literature suggests that the way that B2B systems are measured may explain some of the discrepancies of its effects on SMEs’ performance and efficiency. Hence, the extent of B2B adoption is positively correlated with enterprise performance and efficiency (Brews & Tucci, 2004). 1 Authors’ Accepted Version of Al-Bakri, Anas and Cater-Steel, Aileen and Soar, Jeffrey (2010) The influence of B2B e-commerce on SMEs' performance and efficiency: a review of the literature. International Journal of Liability and Scientific Enquiry, 3 (3). pp. 213-224. ISSN 1741-6426. doi: 10.1504/IJLSE.2010. 033356
La contraception chez les femmes ayant un antécédent de cancer du sein

396 a contraception chez les femmes atteintes de cancer du sein pose un vrai probleme. En France, 10 % des 42 000 nouveaux cas concernent des femmes de moins de 40 ans et 25 a 30 % des femmes de moins de 50 ans. La survenue d’une grossesse n’est actuellement plus contre-indiquee, mais doit etre programmee, apres reflexion, au moment adequat. Disons tout de suite que nous ne savons pas grand chose de l’effet exact d’une contraception hormonale chez une femme ayant eu un cancer du sein et l’ideal serait d’avoir recours a une contraception non hormonale, mais ce n’est pas toujours possible.
Increased Expression of Phospholipase D in the Heart with Experimental Autoimmune Myocarditis in Lewis Rats

The expression of phospholipase D (PLD) in the hearts of rats with experimental autoimmune myocarditis (EAM) was studied to elucidate the functional role of PLD in the pathogenesis of EAM. Western blot analysis showed that the level of the PLD1 isoform was significantly increased in the hearts of rats with EAM on days 14, 17 and 21 postimmunization (pi) (P < 0.01; control vs EAM at 14 pi, 17 pi and 21 pi). The phenotypes of cells exhibiting increased PLD1 expression were primarily inflammatory cells, including ED1 positive macrophages, in the inflammatory EAM lesions. Some cardiomyocytes also showed increased PLD1 immunoreaction in and around EAM lesions. Some PLD1‐positive cells were also positive for proliferating cell nuclear antigen in some cardiomyocytes or terminal deoxynucleotidyl transferase (TdT)‐mediated dUTP nick end‐labeling in some macrophages, suggesting that PLD1 positive cells have a capacity for proliferation or apoptosis depending on cell types in the target organ. Thus, it is postulated that increased expression of PLD1 in EAM may support an early inflammatory response in proliferating inflammatory cells, and its expression in cardiomyocytes may help them to survive by activation of survival factors in hearts with EAM.
Design Issues and Estimation Errors Analysis of Back-EMF-Based Position and Speed Observer for SPM Synchronous Motors

A back-electromotive force-based sensorless technique for surface-mounted permanent magnet synchronous motor drives is considered in this paper. The model of the observer is developed in the Laplace domain and represents an original approach with respect to state-of-art proposals, normally employing a state-space representation. This allows a more intuitive but equivalent design of the observer's gains, based on the standard frequency response, as compared with eigenvalues analysis. Moreover steady-state errors are obtained from a theoretical point-of-view, including the effects of the most common nonidealities affecting the drive system and parameters sensitivity. Full simulation and experimental characterization of the sensorless drive is provided with reference to a general purpose industrial drive, i.e., both in transient and steady-state and in the most meaningful speed/torque operating conditions.
Elastic constants of the human lens capsule

1. A technique is described whereby the elasticity of the human lens capsule has been determined at birth and throughout life. This technique requires three separate determinations: (a) thickness; (b) stress and strain; (c) Poisson's ratio; (a) the capsule was clamped between accurately perforated ground glass plates and its thickness determined by noting the change in depth of focus between Latex spherules adhering to its upper and lower surfaces; (b) the undisturbed capsule was then placed in a specially designed glass distension apparatus and the relationship between volume and pressure recorded when it was distended with isotonic saline. The permeability of the capsule was also measured; (c) in some cases Poisson's ratio was determined by measuring the change of thickness of the capsule and the height to which it rose when distended with isotonic saline at different pressures. An apparatus was designed for this purpose.
FEATURE-BASED VS. INTENSITY-BASED BRAIN IMAGE REGISTRATION: COMPREHENSIVE COMPARISON USING MUTUAL INFORMATION

We propose a mutual information-based method for quantitative evaluation of the deformable registration algorithms at three levels: global, voxel-wise and anatomical structure. We compare two fully deformable registration algorithms: feature-based HAMMER and a set of intensity-based algorithms (FEM-Demons) in the ITK package. Evaluation is carried out using the AAE template image with 116 labeled anatomical structures and a set of 59 MR brain images: 20 normal controls (CTE), 20 Alzheimer's disease patients (AD) and 19 mild cognitive impairment patients (MCI). We show that both HAMMER and FEM-Demons perform significantly better than an affine registration algorithm, FLIRT, at all three levels. At the global level, FEM-Demons outperforms HAMMER on the images of AD and MCI patients. At the local and anatomical levels, FEM-Demons and HAMMER dominate each other on different brain regions.
Demonstration and solubilization of antigens expressed primarily on the surfaces of Candida albicans germ tubes

Antisera against mycelial-phase, but not yeast-phase, Candida albicans absorbed with yeast-phase organisms preferentially stained germ tube segments of several strains of mycelial-phase C. albicans by the indirect fluorescent-antibody staining technique. Germ tube segment antigens were not found in significant amounts on blastospore segments or on yeast-phase organisms. Absorption of the mycelial-phase reference sera with yeast-phase C. stellatoidea, but not with C. tropicalis, C. guillermondii, or Saccharomyces cerevisiae, resulted in preferential germ tube segment staining of C. albicans. A dithiothreitol extract of mycelial-phase C. albicans organisms blocked staining of the germ tube segment, but a dithiothreitol extract of yeast-phase organisms did not. When dithiothreitol extracts from both phases were reacted against yeast-absorbed reference sera in tandem crossed and crossed line immunoelectrophoresis, a cross-reacting arc and several arcs unique to the mycelial-phase extract were noted. Immunofluorescent staining tests were performed, using appropriately absorbed sera from patients with candidiasis to stain a laboratory strain of C. albicans. Human tissue slices infected with C. albicans were used as targets for appropriately absorbed rabbit antisera. These human data indicated that antigens preferentially expressed on the germ tube in vitro were also expressed on filamentous structures of the fungus in infected human tissues. In vitro and in vivo, the invasive mycelial phase of C. albicans expresses certain antigens that are highly concentrated on the germ tube.
Spatially resolved images of dust belt(s) around the planet-hosting subgiant κ CrB

We present Herschel spatially resolved images of the debris disc orbiting the subgiant κ Coronae Borealis (κ CrB). Not only are these the first resolved images of a debris disc orbiting a subgiant, but κ CrB is a rare example of an intermediate mass star where a detailed study of the structure of the planetary system can be made, including both planets and planetesimal belt(s). The only way to discover planets using the radial velocity technique around such stars is to observe ‘retired’ A stars, which are cooler and slower rotators compared to their main-sequence counterparts. A planetary companion has already been detected orbiting the subgiant κ CrB, with revised parameters of msin i = 2.1 M_J and a_(pl) = 2.8 au (Johnson et al. 2008). We present additional Keck I HIRES (High Resolution Echelle Spectrometer) radial velocity measurements that provide evidence for a second planetary companion, alongside Keck II adaptive optics imaging that places an upper limit on the mass of this companion. Modelling of our Herschel images shows that the dust is broadly distributed, but cannot distinguish between a single wide belt (from 20 to 220 au) or two narrow dust belts (at around 40 and 165 au). Given the existence of a second planetary companion beyond ∼3 au it is possible that the absence of dust within ∼20 au is caused by dynamical depletion, although the observations are not inconsistent with depletion of these regions by collisional erosion, which occurs at higher rates closer to the star.
A fully integrated microfluidic genetic analysis system with sample-in–answer-out capability

We describe a microfluidic genetic analysis system that represents a previously undescribed integrated microfluidic device capable of accepting whole blood as a crude biological sample with the endpoint generation of a genetic profile. Upon loading the sample, the glass microfluidic genetic analysis system device carries out on-chip DNA purification and PCR-based amplification, followed by separation and detection in a manner that allows for microliter samples to be screened for infectious pathogens with sample-in–answer-out results in <30 min. A single syringe pump delivers sample/reagents to the chip for nucleic acid purification from a biological sample. Elastomeric membrane valving isolates each distinct functional region of the device and, together with resistive flow, directs purified DNA and PCR reagents from the extraction domain into a 550-nl chamber for rapid target sequence PCR amplification. Repeated pressure-based injections of nanoliter aliquots of amplicon (along with the DNA sizing standard) allow electrophoretic separation and detection to provide DNA fragment size information. The presence of Bacillus anthracis (anthrax) in 750 nl of whole blood from living asymptomatic infected mice and of Bordetella pertussis in 1 μl of nasal aspirate from a patient suspected of having whooping cough are confirmed by the resultant genetic profile.
Les déterminants de la structure du capital : application pour les entreprises canadiennes et américaines de 1995 à 2005

Ce travail se veut une contribution a l'analyse des determinants de la structure de capital des entreprises nord-americaines. Il existe une litterature abondante principalement anglo-saxonne sur ce sujet. Cependant, les resultats empiriques des etudes existantes n'apportent pas encore une reponse definitive a cette question. L'objectif primordial du present memoire est de verifier l'impact de certaines des variables identifiees par la theorie sur l'endettement. Notre etude fait appel aux techniques d'analyse de donnees de panel, lesquelles permettent d'etudier les donnees du bilan et de reduire le biais de selection. Dans un premier temps, nous dressons l'etat de la recherche en exposant les dernieres avancees theoriques en la matiere. A partir d'un panel de firmes americaines et canadiennes, nous presentons, dans un deuxieme temps, les resultats de tests relatifs a certaines hypotheses de comportement financier. Les resultats obtenus confirment nos predictions et montrent que le choix d'une structure d'endettement est loin d'etre neutre. ______________________________________________________________________________ MOTS-CLES DE L’AUTEUR : Structure du capital, Valeur de l'entreprise, Compagnies americaines (US), Compagnies canadiennes (CAN).
Potentially inappropriate prescribing for elderly outpatients in Germany: a retrospective claims data analysis.

OBJECTIVE To quantify the frequency of potentially inappropriate medication (PIM) prescribing for outpatients aged 65 years and older using claims data of a German statutory health insurance. METHODS Based on the 2002 Beers criteria for PIM use, a retrospective evaluation of drug prescription data in outpatient care was conducted for the years 2003 and 2004 using data from a German statutory health insurance (AOK) in the area of Saxony. The study was limited to those drugs classified as being potentially inappropriate according to the criteria independent of existing medical conditions and without any restrictions concerning dosage or duration of use, because this information was not available from the data. RESULTS In 2003, 3.3% (408,375) of all 12,513,584 drug prescriptions for patients 65 years and older which were analyzed included a PIM from the Beers list. In 2004, it was 2.9% (297,524) of 10,126,809 (p < 0.001). The most frequently prescribed PIMs were short-acting nifedipine (13.4%), indomethacin (12.3%) and diazepam (11.8%) in 2003, and diazepam (14.6%) followed by indomethacin (13.7%) and doxazosin (10.9%) in 2004. 21.7% (119,482) and 18.2% (98,465) of patients 65 years or older received at least one prescription of a PIM in 2003 and 2004, respectively (p < 0.001). In a multivariate logistic regression model female gender and a higher number of prescribed drugs were significantly associated with an increased frequency of receiving a PIM in both years. CONCLUSIONS In our study, approximately every 5th older patient was prescribed at least one PIM. For the future an ongoing update of the Beers criteria to further include newer agents and an adaptation to the different situation in European countries is desirable.
Enalapril versus nifedipino para el manejo de la hipertensión arterial postparto

Introduccion: Los desordenes hipertensivos en el embarazo son la mayor causa de morbimortalidad materna en el mundo, su tratamiento habitualmente se realiza con nifedipino o enalapril durante el postparto indistintamente, pero no hay estudios que los comparen. Metodologia: Se realizo un estudio de corte transversal con fines analiticos en el cual se incluyeron las historias clinicas de pacientes con trastorno hipertensivo durante el postparto que recibieron alguno de estos dos medicamentos y se evaluo el control de tension arterial, necesidad de otros antihipertensivos, efectos adversos, presencia de complicaciones en ambos grupos. Resultados: Se estudio una muestra representativa, homogenea de 139 pacientes (p 0,43). Todas controlaron las cifras tensionales con el medicamento recibido. El 45% (n=62) recibio enalapril 20 mg cada 12 horas, el 40% (n=56) recibio nifedipino 30 mg cada 8 horas, el 15% (n=21) recibio nifedipino 30 mg cada 12 horas. No se presentaron efectos adversos, complicaciones o mortalidad en ninguno de los grupos. Las pacientes con enalapril requirieron mas antihipertensivos comparado con las pacientes que recibieron nifedipino con diferencia estadisticamente significativa (p 0,001). Discusion La escogencia de un antihipertensivo durante el postparto debe estar encaminada al tipo de trastorno antihipertensivo: aquellos que se presentan por primera vez durante el embarazo se les administra nifedipino con excelentes resultados; aquellos con antecedente de hipertension previa se les administra enalapril con buenos resultados. Ambos medicamentos controlaron la presion arterial adecuadamente sin complicaciones ni mortalidad.
Energia eólica no Brasil: uma alternativa inteligente frente às demandas elétricas atuais

Inumeros estudos realizados nos ultimos anos tem apontado as implicacoes e impactos socioambientais do consumo de energia. As fontes renovaveis de energia sao referidas como a principal alternativa para atender as demandas da sociedade com relacao a qualidade e a seguranca no atendimento da demanda eletrica, com a reducao dos danos ambientais decorrentes do consumo de energia. O presente artigo apresenta pesquisas realizadas no Brasil acerca do potencial de producao de energia eolica, localizacao das estacoes de coleta de dados eolicos e a relevância da utilizacao desse recurso para geracao de energia eletrica.
Effets de la prise en charge précoce sur la communication prélinguistique dans la trisomie 21

Cette etude a pour but d'evaluer les capacites d'interaction precoce de 14 enfants âges de 25 a 46 mois, porteurs de trisomie 21, ayant beneficie ou non d'une prise en charge precoce orthophonique avant un an. L'evaluation se deroule en deux parties : une situation dirigee de test (ECSP) et une situation naturelle de jeu avec un partenaire connu de l'enfant. L'etude a permis de mettre en evidence l'apport de la prise en charge precoce pour certaines capacites de communication sociale non verbale.
The chirp scaling algorithm of arbitrary formation bistatic SAR imaging

The paper derives a chirp scaling(CS) algorithm for arbitrary transmitter and receiver motion (nonparallel tracks, unequal velocities and antenna squint) in a bistatic synthetic aperture radar(BiSAR) constellation. Based on the bistatic geometry and Taylor series, two halves of monostatic phase histories are expanded in two Taylor series around the individual points of stationary phase to derive the point target spectrum. A novel range scaling formulation is proposed based on the spectrum. Finally, the proposed approach is verified with a point target simulation.