Miracle-dz/UniFAR-FTUs huggingface dataset:
Regional analgesia for improvement of long-term functional outcome after elective large joint replacement.

BACKGROUND Regional analgesia is more effective than conventional analgesia for controlling pain and may facilitate rehabilitation after large joint replacement in the short term. It remains unclear if regional anaesthesia improves functional outcomes after joint replacement beyond three months after surgery. OBJECTIVES To assess the effects of regional anaesthesia and analgesia on long-term functional outcomes 3, 6 and 12 months after elective major joint (knee, shoulder and hip) replacement surgery. SEARCH METHODS We performed an electronic search of several databases (CENTRAL, MEDLINE, EMBASE, CINAHL), and handsearched reference lists and conference abstracts. We updated our search in June 2015. SELECTION CRITERIA We included randomized controlled trials (RCTs) comparing regional analgesia versus conventional analgesia in patients undergoing total shoulder, hip or knee replacement. We included studies that reported a functional outcome with a follow-up of at least three months after surgery. DATA COLLECTION AND ANALYSIS We used standard methodological procedures expected by Cochrane. We contacted study authors for additional information. MAIN RESULTS We included six studies with 350 participants followed for at least three months. All of these studies enrolled participants undergoing total knee replacement. Studies were at least partially blinded. Three studies had a high risk of performance bias and one a high risk of attrition bias, but the risk of bias was otherwise unclear or low.Only one study assessed joint function using a global score. Due to heterogeneity in outcome and reporting, we could only pool three out of six RCTs, with range of motion assessed at three months after surgery used as a surrogate for joint function. All studies had a high risk of detection bias. Using the random-effects model, there was no statistically significant difference between the experimental and control groups (mean difference 3.99 degrees, 95% confidence interval (CI) - 2.23 to 10.21; P value = 0.21, 3 studies, 140 participants, very low quality evidence). We did not perform further analyses because immediate adverse effects were not part of the explicit outcomes of any of these typically small studies, and long-term adverse events after regional anaesthesia are rare.None of the included studies elicited or reported long-term adverse effects like persistent nerve damage. AUTHORS' CONCLUSIONS More high-quality studies are needed to establish the effects of regional analgesia on function after major joint replacement, as well as on the risk of adverse events (falls).
Opponent Color Responses in Retinal Ganglion Cells

The receptive fields of certain ganglion cells in the goldfish retina have been mapped. These fields are "off" center. "on-off" intermediate, and "on" periphery types. The excitatory process controlling the "on" response is stimulated maximally by green light; the "off" response process, inhibitory in nature, is stimulated maximally by red light. The two processes can be light adapted independently.
Association of EPAS1 Gene rs4953354 Polymorphism with Susceptibility to Lung Adenocarcinoma in Female Japanese Non-Smokers

Introduction: Hypoxia-inducible factor-2&agr; (also called endothelial periodic acid–Schiff domain protein 1 [EPAS1]) seems to play an important role in some carcinogenesis, though there is no information on the relationship between single nucleotide polymorphism of EPAS1 and lung cancer development. The aim of this study was to explore a possible association of the EPAS1 gene rs4953354 polymorphism with susceptibility to lung cancer. Methods: A case–control study of 346 patients with non–small-cell lung carcinoma (adenocarcinoma = 249, squamous cell carcinoma = 97) and 247 healthy control subjects was carried out. A/G polymorphism within an intron 2 of the EPAS1 (rs4953354) was determined by direct sequencing. Results: A frequency of lung adenocarcinoma patients with a minor allele G (A/G or G/G genotype) at the rs4953354 was much higher than that of controls (odds ratio, 1.800; 95% confidence interval, 1.161–2.791; p = 0.008). This association was more evident when analyzed using female never-smokers (odds ratio, 3.31; 95% confidence interval, 1.21–9.01; p = 0.017). Mutations in epidermal growth factor receptor tended to be frequent in patients with G allele at the rs4953354, compared with those with other genotypes. Conclusion: The EPAS1 rs4953354 may be a potentially susceptible marker for development of lung adenocarcinoma, especially in female never-smokers.
Export of PfSBP1 to the Plasmodium falciparum Maurer’s Clefts

The human malaria parasite Plasmodium falciparum exports determinants of virulence and pathology to destinations within the host erythrocyte, including the erythrocyte cytoplasm, plasma membrane and membrane profiles of parasite origin termed Maurer’s clefts. Most of the exported proteins contain a conserved pentameric motif termed plasmodial export element (PEXEL)/vacuolar transfer signal (VTS) that functions as a cleavable sorting signal permitting export to the host erythrocyte. However, there are some exported proteins, such as the skeleton‐binding protein 1 (PfSBP1) that lack the PEXEL/VTS motif and that are not N‐terminally processed, suggesting the presence of alternative sorting signals and/or mechanisms. In this study, we have investigated trafficking of PfSBP1 to the Maurer’s clefts. Our data show that the transmembrane domain of PfSBP1 functions as an internal signal sequence for entry into the parasite’s secretory pathway and for transport to the parasite plasma membrane. Trafficking beyond the parasite’s plasma membrane required additional N‐terminal domains, which are characterized by a high negative net charge. Biochemical data indicate that these domains affect the solubility and extraction profile, the orientation of the protein within the membrane and the subcellular localization. Our findings suggest new principles of protein export in P. falciparum‐infected erythrocytes.
Friend recommendation system for online social networks: A survey

The social network users always need personalized information. In the present scenario, people are not willing to spend a lot of time to specify their personal needs. So a system is needed which automatically suggest personalized things to users. The Recommendation system is a system which is used to recommend resources that user may be interested in by mining users' interests and/or preferences. There are different types of recommendation system in social network and each of this system uses different technologies for recommendation. The friend recommendation system is such a system which automatically suggests potential friends to users. This paper does a survey of different friend recommendation systems using different techniques. In this literature a comparative study of the methodology is also done.
A System Design for Teleoperated Road Vehicles

The possibility to provision road vehicles unmanned and on demand will have an important influence on the development of new mobility concepts. We therefore present the teleoperated driving of road vehicles. This paper outlines the basic concepts, including a static multi-camera design, an operator interface with a sensor fusion based display, and a cellular network based video transmission and communication architecture. We also show how we manage to fulfill the system's technical requirements with our hard- and software design and point out the occurring problems due to communication limitations and lack of situation awareness. Finally, we propose solutions to guarantee driving safety.
Crystal structure of the carbon monoxide complex of human cytoglobin

Cytoglobin (Cgb) is a vertebrate heme‐containing globin‐protein expressed in a broad range of mammalian tissues. Unlike myoglobin, Cgb displays a hexa‐coordinated (bis‐hystidyl) heme iron atom, having the heme distal His81(E7) residue as the endogenous sixth ligand. In the present study, we crystallized human Cgb in the presence of a reductant Na2S2O4 under a carbon monoxide (CO) atmosphere, and determined the crystal structure at 2.6 Å resolution. The CO ligand occupies the sixth axial position of the heme ferrous iron. Eventually, the imidazole group of His81(E7) is expelled from the sixth position and swings out of the distal heme pocket. The flipping motion of the His81 imidazole group accompanies structural readjustments of some residues (Gln62, Phe63, Gln72, and Ser75) in both the CD‐corner and D‐helix regions of Cgb. On the other hand, no significant structural changes were observed in other Cgb regions, for example, on the proximal side. These structural alterations that occurred as a result of exogenous ligand (CO) binding are clearly different from those observed in other vertebrate hexa‐coordinated globins (mouse neuroglobin, Drosophila melanogaster hemoglobin) and penta‐coordinated sperm whale myoglobin. The present study provides the structural basis for further discussion of the unique ligand‐binding properties of Cgb. Proteins 2011. © 2011 Wiley‐Liss, Inc.
An efficient algorithm for mining top-rank-K frequent patterns from uncertain databases

The analysis and management of uncertain data has gained a lot of importance in the past few years because of their importance in a wide variety of applications such as sensor network and privacy preserving data mining applications. Many algorithms have been proposed to mine the frequent pattern over uncertain database. However the existing algorithms for uncertain data generate a large no. of candidate patterns and required to define an appropriate user defined threshold which is a challenging task for users. In this paper, we propose a new algorithm known as UFAE (uncertain filtering and extending) algorithm to mine top-rank-k frequent itemset or patterns. Mining only top-rank-k frequent pattern greatly decrease the number of candidate pattern generated so reduce the mining time. Many algorithms exist to mine top-rank-k frequent itemset in case of precise data but none in case of uncertain database. Experiments are performed to evaluate the performance of the algorithm on various dataset.
Epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor in labial salivary glands in Sjögren's syndrome.

OBJECTIVE Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) affect cells through binding to a shared EGF receptor (EGF-R), which is a transmembrane protein with tyrosine kinase activity. They exert trophic effects on vascular endothelial, salivary acinar, and ductal and mucosal epithelial cells. In Sjögren's syndrome (SS) focal sialadenitis leads to salivary gland tissue damage, diminished salivary flow, and changes in the oral epithelium, a complex referred to as xerostomia. We compared the localization of EGF, TGF-alpha, and EGF-R in labial salivary glands in SS and in healthy controls. METHODS Labial salivary gland tissues of 12 patients with SS and 7 healthy controls were stained with the immunohistochemical peroxidase-antiperoxidase method for EGF, TGF-alpha, and EGF-R. RESULTS Immunoreactivity for both EGF and TGF-alpha was found in endothelial cells of blood vessels and in some ductal epithelial cells. TGF-alpha, but not EGF, was also found in some acinar cells. EGF-R was found in endothelial, acinar, and salivary duct epithelial cells. There was no difference in the expression of EGF-R between diseased and healthy specimens, but both EGF and TGF-alpha were diminished in SS. CONCLUSION The interrelated localization of EGF-R and its ligands, EGF and TGF-alpha, suggests an autocrine, juxtacrine, and paracrine mitogenic/trophic role for them and thus a role in the maintenance of the secretory and excretory cells of the normal salivary glands. The trophic effects on acinar cells seem not to be mediated by EGF, but more likely by TGF-alpha. The diminished expression of EGF and TGF-alpha indicates a failure of this trophic system in SS, which may contribute to the acinar atrophy and secondary changes thereof, including atrophy of the oral mucosa.
Cytological criteria for the diagnosis of intraductal hyperplasia, ductal carcinoma in situ, and invasive carcinoma of the breast

The advent of mammography screening presents a diagnostic challenge to the cytopathologist as an increasing proportion of breast lesions requiring investigation will be nonpalpable and up to 40% will be accounted for by atypical intraductal hyperplasia and ductal carcinoma in situ, as opposed to previously, when these lesions represented less than 10% of palpable tumors. We studied 133 fine‐needle aspirates from breast tumors and found that nuclear morphology, myoepithelial cells, signs of invasion, and degree of cellular dissociation are among the most potent factors discriminating between benign epithelial proliferations, atypical intraductal hyperplasia, ductal carcinoma in situ, and invasive carcinoma. Diagn. Cytopathol. 2004;31:207–215. © 2004 Wiley‐Liss, Inc.
Effets non-linéaires et qualité de la mesure en électrodynamique quantique en circuit

par Maxime Boissonneault mémoire présenté au département de physique en vue de l'obtention du grade de maˆıtrè es sciences (M.Sc.) Le , le jury a accepté le mémoire de M. Boissonneault dans sa version finale. Remerciements Merci tout d'abordà mes différents superviseurs de stage et autre : René Côté, Serge Charlebois, André-Marie Tremblay et Alexandre Blais. Merci de m'avoir initiéà la re-cherche, j'ai beaucoup appris grâcè a vous. Un merci particulierà Alexandre pour ces deux années de physique effervescente, et pour ta patience pour avoir lu mes notesà de nombreuses reprises. Ludo, Julie, Sylvain, pour toutes ces discussionettes (ou parfois plus longues) parfois compì etement absurdes sur le volume d'un café en parsec 3 ou sa température en cm −1 , cesbì eres (ahhh, la Leffe Brune ! ), ces moments inoubliables. Aussi pour un certain voyage au BC, o` u on a fait 2000km pour acheter du vin et pris des photos en conduisant, et pour un autrè a Denver etévidemmentà Magog, pas très loin, mais toujours intéressant en votre compagnie ! Un merci particulierà Phi, confidente et toujours disponible en cas de besoins. J'espère qu'on pourra encore se comprendre parfois juste par un regard et pouffer de rire ! Un grand merci aussì a mes parents Yvon et Denise, et ma famille, Patrice et Josée, pour m'avoir toujours encouragé dans mon parcours. Merci aussì a mon copain, Joannick, pour ton support, ta patience et ton côté relaxé et relaxant qui pouvait calmer mes nerfs de temps en temps (ou faire l'inverse ! ) Je voudrais aussi remercier certains professeurs qui m'ont donné le goût de la science. (pour les consultations gratuites), David Sénéchal, René Côté et André-Marie Tremblayà l'université. C'est entre autre grâcè a vous tous que j'en suis rendu l` a aujourd'hui. Finally, a big thanks to Jay Gambetta, whose collaboration was very important for this work. Merci aussi au CCS pour le support technique, ainsi qu'` a un certain Mammouth et Elix2, qui ont fait la majorité du travail (37 786 heures de calcul ! ), sans qui ces résultats n'auraient jamais pû etre produits. Merci enfin au CRSNG pour le support financier.
Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97

Postsynaptic targeting of the Drosophila tumour suppressor discs‐large (Dlg) critically depends on its SH3 and GK domains. Here, we asked whether these domains are also involved in subcellular targeting of the mammalian Dlg homolog SAP97 and its interacting partners in CNS cortical neurons by analysing a recently described mouse mutant lacking the SH3 and GK domains of SAP97. Both wildtype and truncated SAP97 were predominantly expressed in perinuclear regions, in a pattern suggesting association with the endoplasmic reticulum. Weaker immunoreactivity was found in neurites colocalizing with both dendritic and axonal markers. As SAP97 has been implicated in the early intracellular processing of the glutamate receptor GluR1, we studied biochemical maturation and subcellular localization of GluR1 in the mutants. Both the glycosylation pattern and synaptic clustering of GluR1 were indistinguishable from wildtype mice. Synaptic clustering of the guanylate kinase domain interacting protein GKAP was also intact. Our data demonstrate that truncation of the SH3 and GK domains of SAP97 in mice does neither change its subcellular distribution nor does it disrupt synaptic structure or protein clustering, as opposed to severe missorting of the respective mutant Dlg protein in Drosophila.
Managing Pregnant Women with Serious Mental Illness: Using the Edinburgh Postnatal Depression Scale as a Marker of Anxiety and Depressive Symptoms

Objective: To examine the course of depressive and anxiety symptoms using serial measurements of the Edinburgh Postnatal Depression Scale (EPDS) in pregnant women with serious mental illness (SMI) attending a specialist multi-disciplinary antenatal clinic in Perth, Western Australia. Method: A retrospective review of case notes was undertaken for 48 Western Australian pregnant women with schizophrenia and related psychoses and bipolar affective disorders who attended the Childbirth and Mental Illness (CAMI) antenatal clinic between December 2007 and November 2009. Of these patients, 27 completed the EPDS at booking (first appointment) and at 32 weeks gestation. Additional variables collected were demographic data, gestation at booking, and attendance rates for these 27 women, and for comparison another 21 women who did not complete the EPDS for one or both screening periods. Results: Mean total EPDS score decreased from 12.2 (SD 7.6) at booking to 8.5 (SD 6.4) at 32 weeks gestation (p = 0.007). Overall mean attendance rates and number of appointments were similar to the non-SMI population and in keeping with standard guidelines. Conclusions: We speculate from these preliminary findings that being managed by a consistent small multi-disciplinary team and knowing that they will be supported throughout their pregnancy could lead to improvement of anxiety and depressive symptoms in pregnant women with SMI, and has the potential to increase their attendance for antenatal care.
Rifampin-Fluconazole Interaction in Critically ILL Patients

Objective: To report the influence of rifampin coadministration on the pharmacokinetics of fluconazole in 2 critically ill patients. Case Summaries: The pharmacokinetics of fluconazole are reported in 5 patients in the intensive care unit (ICU), 2 of whom received rifampin and 3 who received only fluconazole. Patient 1 was a 52-year-old man with bilateral pneumonia who received rifampin for 9 days in addition to other antibiotics when fluconazole was added for suspected fungal superinfection. Patient 2, a 39-year-old man with steroid-dependent asthma was admitted to the ICU with a right middle lobe pneumonia and ventilatory insufficiency. Because of rapid clinical deterioration, intravenous rifampin 600 mg q12h and fluconazole 100 mg q24h were added to conventional antibacterial therapy. Patients 3–5 received intravenous fluconazole therapy, but were never administered rifampin prior to their antifungal therapy. Discussion: Fluconazole has gained wide use as an antifungal agent because of its efficacy, limited toxicity, and the paucity of reported drug interactions. In some clinical situations, however, the drug must be coadministered with rifampin. Limited data in healthy volunteers suggest that the coadministration of rifampin and fluconazole results in a 23% reduction in the fluconazole area under the concentration-time curve (AUC). In this report, we found a statistically significant lowering of the AUC (52%) and a 93% higher total body clearance of fluconazole in patients treated with rifampin. Conclusions: Although limited data are available describing the magnitude of the interaction between fluconazole and rifampin in patients, our data suggest a more significant interaction than previously reported. If the concurrent administration of the 2 drugs is unavoidable, the patient's clinical response to treatment should be monitored closely, as the unexpectedly large reduction in fluconazole serum concentrations may lead to poor treatment outcomes.
Seizure‐Triggering Mechanism in the Kindling Model of Epilepsy: I. EEG Changes during Stimulation from the Site of Stimulation

Male Sprague-Dawley rats stereotaxically received standard tripolar electrodes into the amygdala (AM) or hippocampus (HIPP) under pentobarbital anesthesia. A kindling stimulation of 2 sec, 100 Hz, 200 PA, bipolar diphasic pulses was delivered once daily to the AM or HIPP until stable generalized seizures were induced. Then a tetanic stimulation of 5 sec with various frequencies of 10, 30, 40 and 100 Hz was given to the AM. The other parameters were the same as mentioned above. In the AM kindled rats, the GABA antagonist ( picrotoxin 1 mg/kg, bicuculline 1 mg/kg, DL-C-allylglycine 50 mg/kg), benzodiazepine (diazepam 2 mg/ kg) , monoamine agonist and antagonist (D-amphetamine 5 mg/kg, reserpine 2.5 mg/kg) or adenosine antagonist (aminophylline 50 mg/kg) was systemically administered and the kindling stimulation was delivered to the AM. The effects of these pharmacological manipulations on EEG changes during the stimulation were measured and compared to each control. Results and Discussion
Behavioral / Systems / Cognitive Ensemble Coding of Vocal Control in Birdsong

Zebra finch song is represented in the high-level motor control nucleus high vocal center (HVC) (Reiner et al., 2004) as a sparse sequence of spike bursts. In contrast, the vocal organ is driven continuously by smoothly varying muscle control signals. To investigate how the sparse HVC code is transformed into continuous vocal patterns, we recorded in the singing zebra finch from populations of neurons in the robust nucleus of arcopallium (RA), a premotor area intermediate between HVC and the motor neurons. We found that highly similar song elements are typically produced by different RA ensembles. Furthermore, although the song is modulated on a wide range of time scales (10 –100 ms), patterns of neural activity in RA change only on a short time scale (5–10 ms). We suggest that song is driven by a dynamic circuit that operates on a single underlying clock, and that the large convergence of RA neurons to vocal control muscles results in a many-to-one mapping of RA activity to song structure. This permits rapidly changing RA ensembles to drive both fast and slow acoustic modulations, thereby transforming the sparse HVC code into a continuous vocal pattern.