Miracle-dz/UniFAR-FTUs huggingface dataset:
Local-global splitting as a framework for multiscale multiphysics simulations . • Spatiotemporal adaptivity for the Multiscale Finite

We present a novel spatiotemporal-adaptive Multiscale Finite Volume (MsFV) method, which is based on the natural idea that the global coarse-scale problem has longer characteristic time than the local fine-scale problems. As a consequence, the global problem can be solved with larger time steps than the local problems. In contrast to the pressure-transport splitting usually employed in the standard MsFV approach, we propose to start directly with a local-global splitting that allows to locally retain the original degree of coupling. This is crucial for highly non-linear systems or in the presence of physical instabilities. To obtain an accurate and efficient algorithm, we devise new adaptive criteria for global update that are based on changes of coarsescale quantities rather than on fine-scale quantities, as it is routinely done before in the adaptive MsFV method. By means of a complexity analysis we show that the adaptive approach gives a noticeable speed-up with respect to the standard MsFV algorithm. In particular, it is efficient in case of large upscaling factors, which is important for multiphysics problems. Based on the observation that local time stepping acts as a smoother, we devise a self-correcting algorithm which incorporates the information from previous times to improve the quality of the multiscale approximation. We present results of multiphase flow simulations both for Darcy-scale and multiphysics (hybrid) problems, in which a local pore-scale description is combined with a global Darcy-like description. The novel spatiotemporal-adaptive multiscale method based on the local-global splitting is not limited to porous media flow problems, but it can be extended to any system described by a set of conservation equations.
Rôle des ganglions de la base lors de mouvements d'origine interne et externe des mains dominante et non-dominante; une étude IRMf

It has been proposed that the putamen is more involved during self-initiated (SI) nov el movements than in externally-triggered (ET) ones. Furthermore, increased activation of the subthalamic nucleus (STN) has been linked with movement selection and inhibition of concurring motor events. However, their role remains unclear in the context of bimanual finger movements. In this study, we used 3T fMRI to study their role in the context of a bimanual finger movement task, in healthy right-handed young adults. For each hand, the participant had to perform a SI condition, an ET condition and a control one. We focused on three contrasts, SI vs. control, ET vs. control, and SI vs. ET conditions. The results showed significantly increased activity in the putamen bilaterally in aIl contrasts, except, for the left hand, when the ET condition was compared to control. The observed results provide further evidence that the putamen is required for the planning and execution of non-routine movements, particularly for SI novel movements. Significant increased STN activation was observed when comparing SI to control for the left and the right hand. However, when comparing the SI conditions to the ET conditions, it was only observed for the left hand. The patterns of activity observed in the STN indicate its involvement in movement selection and inhibition of concurrent ones. FinaIly, throughout the contrasts, greater and larger cortical and subcortical activation was observed for conditions using the left hand than the right one, which leads us to propose that in right-handed humans, fine motor movements of the left hand require more resources, both cortically and subcorticaIly.
Deep Metazoan Phylogeny

We reconstructed a robust phylogenetic tree of the Metazoa, consisting of almost 1,500 taxa, by profile neighbor joining (PNJ), an automated computational method that inherits the efficiency of the neighbor joining algorithm. This tree supports the one proposed in the latest review on metazoan phylogeny. Our main goal is not to discuss aspects of the phylogeny itself, but rather to point out that PNJ can be a valuable tool when the basal branching pattern of a large phylogenetic tree must be estimated, whereas traditional methods would be computationally impractical.
A novel dual active bridge topology with a tuned CLC network

This paper proposes a novel resonant DAB converter, which uses a tuned capacitor-inductor-capacitor (CLC) network. In comparison to conventional DABs, the proposed topology significantly reduces the bridge currents, lowering both conduction and switching losses and improving power factors associated with the bridges. A mathematical model, which predicts the behavior of the proposed system, is presented to show that both the magnitude and direction of the power flow can be controlled through either relative phase angle or pulse width modulation of voltages produced by the bridges. Viability of the proposed concept is verified through simulation. Experimental results of a 1 kW prototype converter, which has an efficiency of 95% at rated power, are also presented with discussions to demonstrate the improved performance of the CLC DAB topology.
Lenguas indígenas de Colombia

No se trata de un libro para ser guardado pasivamente en el anaquel. Por su tamaño, su peso y su seducción policromática es un libro que invita a ser tocado y, por supuesto, a ser abierto para hacerse texto; la mesa, en la sala de espera o el escritorio donde se atiende a quien indaga, es el mejor lugar para que este libro presuma de su sapiencia; nadie reprime la tentación de palparlo y de auscultar lo que a través de 848 páginas nos muestra. Un halo de extrañeza despierta este libro descomunal, que nos acerca a la historia maravillosa, aunque a veces dolorosa, de las lenguas aborígenes de Colombia. Lo que parece ser denso por el carácter descriptivo y formal de las lenguas se hace amable al lector neófito cuando su mirada discurre entre las fotografías, los esquemas, los mapas y las explicaciones de las singularidades de cada una de las lenguas estudiadas. Pero, además, para el investigador en lingüística y en historia de la cultura, así como para los maestros, habrá de constituir un referente fundamental, pues nos encontramos ante un balance, o un estado de la cuestión, de lo que hasta ahora se ha analizado de las lenguas vivas de las comunidades indígenas. Bien valió la pena la insistencia de las coordinadores del libro, María Stella González y María Luisa Rodríguez, quienes confiesan el carácter dispendioso de la hechura de un libro que requería, en muchos de sus apartados, de linotipos no incorporados en la imprenta y de convenciones fonéticas ausentes en los programas de la computadora.
Distribution of the Coronary Blood Flow across the Canine Heart Wall during Systole

The transmural distribution of left coronary blood flow during systole was studied by measuring the myocardial uptake of a bolus of 86Rb introduced into the coronary circulation when the perfusion was limited to the periods of systole. The measurement revealed a transmural gradient of systolic blood flow with a flow rate in the outer fourth of the left ventricle about twice that in the inner fourth. A gradient of flow encompassing all depths of myocardial tissue revealed that intramyocardial pressure during systole was not sufficient to completely collapse the vessels and, therefore, did not exceed intraventricular pressure. The results of this experiment indicate that intramyocardial pressure limits coronary blood flow through a vascular sluice mechanism.
University of Groningen Measuring Steroid Hormones in Avian Eggs

Avian eggs contain substantial levels of various hormones of maternal origin and have recently received a lot of interest, mainly from behavioral ecologists. These studies strongly depend on the measurement of egg hormone levels, but the method of measuring these levels has received little attention. This paper describes the sampling, extraction, and assay of hormones in avian eggs and related methodological problems. The method of sampling is important because hormones are not homogeneously distributed within the egg, and after onset of embryonic development their levels may decrease and increase due to changes in egg structure and secretion or uptake of hormones by the embryo. The extraction of hormones from the yolk and chromatographic separation of different hormones for immunoassays can strongly influence the results because such procedures remove interfering substances such as proteins, lipids, and other hormones and their metabolites, which can cross-react with the antiserum used. Finally, the assay itself needs more validation than many studies report, especially with respect to the accuracy and specificity of the hormone measurements. We conclude that the addressed issues need more attention for the correct interpretation of differences in hormone levels within and between studies.
Antibodies to adult t‐cell leukemia‐virus‐associated antigen (atla) in sera from patients with atl and controls in japan: A nation‐wide sero‐epidemiologic study

A nation‐wide sero‐epidemiologic survey of adult T‐cell leukemia virus (ATLV), detected es anti‐ATLA (ATLV‐associated antigen), was made in Japan. Sera from adult donors in 15 different locations were screened for anti‐ATLA. High incidences (6 to 37%) of antibody‐positive donors were found in seven regions, one in northern Japan, and the others in southwestern regions. These areas are ATLV‐endemic areas corresponding to ATL‐endemic areas. Examination of sera from healthy donors aged 6 to 80 years in ATL‐endemic areas showed an age‐dependent increase of seropositive donors with a maximum of about 30% at 40 years of age. Anti‐ATLA was found in all but two of 142 patients with ATL Anti‐ATLA‐positive patients with ATL were mainly found in ATLV‐endemic areas, and only a few in ATL‐nonendemic areas. Six patients with cutaneous T‐cell lymphoma in ATLV‐nonendemic areas gave a negative reaction for anti‐ATLA. The geometric mean titer of anti‐ATLA of patients with ATL was higher than that of healthy donors.
Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds

The list of activities of plant flavonoids did not include effects on the central nervous system (CNS) up to 1990, when our laboratory described the existence of natural anxiolytic flavonoids. The first of these was chrysin (5,7‐dihydroxyflavone), followed by apigenin (5,7,4′‐trihydroxyflavone) and flavone itself. Semisynthetic derivatives of flavone obtained by introducing halogens, nitro groups or both in its molecule, give rise to high affinity ligands for the benzodiazepine receptor, active in‐vivo; 6,3′‐dinitroflavone, for example, is an anxiolytic drug 30 times more potent than diazepam.
A comparison among different methods for evaluating the biomass activity in activated sludge systems: preliminary results.

In order to improve activated sludge plant operation (achieving higher efficiency and cost savings) beside influent and effluent characteristics and working parameters (e.g. dissolved oxygen, total and volatile suspended solids, pH, recirculation flow rate, etc.), the biomass activity should be monitored, the bacteria being responsible for the pollutant degradation. Since conventional cultivation based methods are inadequate to quantify environmental microorganisms (due to scarce number of cultivable microorganisms and time-consuming procedures) several "non-conventional" techniques were applied in this study, in order to compare the obtainable information and their routine feasibility. Different measurements (VSS concentration, Oxygen Uptake Rate, microbial counts by cultural and biomolecular methods--MPN-PCR, ATP content, dehydrogenase activity, microbial cell viability and enzymatic activity) were carried out on mixed liquor samples, taken from a municipal activated sludge plant (440,000 p. e.). The preliminary results of the research are presented in this paper.
Frame rate up-conversion considering multiple motion

Because of different television standards, format conversion is necessary to interchange video programs globally. To this end, temporal interpolation is required for conversion between formats with different frame rate. Adaptive interpolation based on motion estimation offers movement-oriented filtering and provides significant improvement over other methods. However, algorithms proposed so far do not offer a sufficient conversion quality when the motion in the scene is critical. To overcome this problem, a new algorithm for frame rate up-conversion considering multiple motion is developed. At first, a set of candidate vectors for the true movements are detected by block processing and then the appropriate vectors are assigned pixel-wise. Finally, the missing frames are interpolated using these vectors. The proposed method is evaluated by computer simulation and simulation results are included.
Barrières à l'utilisation des outils de diagnostic de la dépression en médecine de famille : étude qualitative par entretiens individuels semi-directifs auprès de médecins généralistes du Nord-Finistère

Introduction : La depression est une pathologie frequente et lourde de consequences sur le plan humain et societal. Son diagnostic, base sur des criteres diagnostiques internationaux, pourrait etre renforce par l'utilisation d'outils diagnostiques. Ces outils diagnostiques sont encore peu utilises en medecine generale. Le but de l'etude etait d'evaluer ces freins pour qu'ils soient pris en compte en pratique de medecine generale. Methode : Etude qualitative par entretiens individuels semi-directifs aupres d'un echantillon raisonne de medecins generalistes. Les verbatims ont beneficie d'un double encodage lineaire independant jusqu'a saturation. L'encodage lineaire a beneficie d'une analyse inductive. Un codage axial et systematique consensuel a ete obtenu. Il a ete organise selon un schema heuristique. Resultats : La saturation a ete obtenue en 9 entretiens. 65 codes axiaux ont ete obtenus. Trois themes ont ete trouves. Les outils etaient meconnus (carence de formation). Ils etaient juges inutiles en pratique. Ils etaient juges inadaptes dans leur indication et dans leur forme. Discussion : Ces barrieres, justifiees par les specificites de l'exercice pratique du medecin generaliste, mettaient en avant deux axes pour ameliorer l'utilisation d'un outil. D'une part, il serait a promouvoir en formation medicale et aupres du patient. D'autre part, une attention particuliere devrait etre portee a son ergonomie : clair, rapide d'utilisation, accessible au cabinet, flexible, ses objectifs devraient etre larges et bien definis. Conclusion : la promotion d'un nouvel outil diagnostic de la depression doit s'adapter a la pratique des medecins generalistes.
Pure word deafness after bilateral primary auditory cortex infarcts

In pure word deafness, comprehension and repetition of speech are impaired, but reading, writing, and spontaneous speech are preserved. Pure word deafness is distinguished from generalized auditory agnosia by the preserved ability to recognize environmental sounds. We examined a patient with pure word deafness associated with bilateral infarctions of the primary auditory cortex, who could use auditory affective intonation to enhance comprehension. The primary auditory cortex seems to be essential for comprehending speech, but comprehension of nonverbal sounds and affective prosody may be mediated by other cerebral structures such as the auditory association cortex.
Osteocutaneous Radial Forearm Free Flaps: The Necessity of Internal Fixation of the Donor-Site Defect to Prevent Pathological Fracture*

Background: Osteocutaneous radial forearm free flaps have fallen from favor due to pathological fractures of the radius. The purposes of this study were to propose a means to decrease the rate of pathological fracture by prophylactic fixation of the donor-site defect and to evaluate this technique biomechanically. Methods: Two groups of ten matched pairs of fresh-frozen cadaveric radii were harvested. In Group 1, an eight-centimeter length of radius comprising 50 percent of the cross-sectional area of the bone was removed to simulate an osteocutaneous radial forearm donor-site defect. This defect was created in one member of each pair, with the other bone in the pair left intact. In Group 2, both members of the ten matched pairs of radii had identical defects created as previously described. However, one radius in each pair had a twelve-hole, 3.5-millimeter dynamic compression plate placed across the segmental defect. In each group, five matched pairs were tested to failure in torsion and five matched pairs were tested to failure in four-point bending. Results: In Group 1, the intact radius was a mean of 5.7 times stronger in torsion and 4.2 times stronger in four-point bending than the radius with the segmental resection. In Group 2, the radius that was ostectomized and fixed with a plate was a mean of 4.0 times stronger in torsion and 2.7 times stronger in four-point bending than the ostectomized radius. Conclusions: Removal of an eight-centimeter segment from the radius dramatically decreased both torsion and bending strength. Application of a plate over the defect in the radius significantly restored the strength of the radius (p = 0.01). Clinical Relevance: The segmental defect created in the radius when an osteocutaneous radial forearm free flap is harvested weakens the donor bone an unacceptable amount, resulting in a high risk of pathological fracture. We believe that prophylactic internal fixation of the donor-site defect with a plate restores strength to such a level that pathological fracture may be prevented, thus increasing the utility of the osteocutaneous radial forearm free flap.
Linguística de Corpus e identidade: uma análise das construções identitárias nos sambas da Escola de Samba Mocidade Independente de Padre Miguel

O presente artigo objetiva descrever, analisar e discutir as construcoes identitarias que emergem nos sambas da escola de samba Mocidade Independente de Padre Miguel. O aporte teorico e metodologico insere-se na Linguistica de Corpus, com utilizacao do programa MonoConc Pro para a geracao, selecao e organizacao dos dados de analise. O trabalho tambem dialogara com discussoes sociologicas sobre samba e identidade, procurando ampliar as discussoes e os resultados da analise.
ANAEROBIC DIGESTION

The digestion process begins with bacterial hydrolysis of the input materials. Insoluble organic polymers, such as carbohydrates, are broken down to soluble derivatives that become available for other bacteria. Acidogenic bacteria then convert the sugars and amino acids into carbon dioxide, hydrogen, ammonia, and organic acids. These bacteria convert these resulting organic acids into acetic acid, along with additional ammonia, hydrogen, and carbon dioxide. Finally, methanogens convert these products to methane and carbon dioxide. The methanogenic archaea populations play an indispensable role in anaerobic wastewater treatments.
Medical system based multi-tasking digital wrist watch using VHDL

The main aim of this paper is to develop a low cost, low power, reliable, easily portable, compact size vital signs that processes and analyses the data acquired from sensors to determine if they are within “Normal” range or not. The methodology used in this manuscript is fingertip sensor using photo diodes and designing a FPGA using VHDL Programming. In today's very competitive business environment, building a cost effective products in a quick fashion is best done with a top down methodology utilizing hardware description languages and synthesis. So, this system is overall a wrist watch with Blood Pressure, Heart Rate, Lie detector monitoring. We can use this watch in different fields as well as for research purpose by further manipulation in programming and interfacing it can be modified accordingly.
5-Hydroxymethylcytosine expression is associated with poor survival in cervical squamous cell carcinoma.

OBJECTIVE Deoxyribonucleic acid methylation is an important epigenetic modification that is frequently altered in cancer. Recent reports showed that the level of 5-hydroxymethylcytosine was altered in various types of cancers. The influence of deoxyribonucleic acid methylation in cervical squamous cell carcinoma is not fully understood. In this study, we investigated 5-hydroxymethylcytosine and ten-eleven translocation expression in cervical squamous cell carcinoma and whether they are associated with poor survival in cervical squamous cell carcinoma. METHODS We detected the expression of 5-hydroxymethylcytosine, 5-methylcytosine and TET1/2/3 in 140 patients with cervical squamous cell carcinoma and 40 patients with normal cervical tissues by immunohistochemistry. We assessed the prognostic values of 5-hydroxymethylcytosine, 5-methylcytosine and TET2 in the clinical outcome of cervical squamous cell carcinoma. RESULTS Expression of 5-hydroxymethylcytosine was significantly decreased in cervical squamous cell carcinoma compared with normal cervix tissues. In contrast, 5-methylcytosine expression was significantly increased in cervical squamous cell carcinoma compared with normal cervix tissues. Moreover, expression of TET2, but not TET1 and TET3, was decreased in cervical squamous cell carcinoma. Our study showed that the decreased level of 5-hydroxymethylcytosine predicts poor prognosis of cervical squamous cell carcinoma patients. The expression of 5-hydroxymethylcytosine was an independent prognostic factor for both disease-free and overall survival of cervical squamous cell carcinoma patients. CONCLUSIONS In cervical squamous cell carcinoma, less aggressive tumor behavior was correlated with 5-hydroxymethylcytosine and TET2. Our data indicated that 5-hydroxymethylcytosine may become a prognostic marker for cervical squamous cell carcinoma and the decreased expression of TET2 may be an underlying mechanism for decreased 5-hmC in cervical squamous cell carcinoma.
Trends and recurrence of placenta praevia: A population‐based study

We determined recent trends and recurrence rates of placenta praevia in 790,366 deliveries in NSW. From 2001 to 2009, the rate of placenta praevia increased by 26%, from 0. 69% to 0. 87% (trend P < 0.001). The placenta praevia recurrence rate in a second birth was 4.8%. Two‐thirds of the increase in placenta praevia was accounted for by trends in known risk factors, and the unexplained portion may reflect changes in unidentified risk factors or in the threshold for placenta praevia diagnosis.
Electron Holography Study of the Charging Effect in Microfibrils of Sciatic Nerve Tissues

Abstract The charging effects of microfibrils of sciatic nerve tissues due to electron irradiation are investigated using electron holography. The phenomenon that the charging effects are enhanced with an increase of electron intensity is visualized through direct observations of the electric potential distribution around the specimen. The electric potential at the surface of the specimen could be quantitatively evaluated by simulation, which takes into account the reference wave modulation due to the long-range electric field.