Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline‐rich region of vinculin.

The ability of Listeria monocytogenes to move within the cytosol of infected cells and their ability to infect adjacent cells is important in the development of infection foci leading to systemic disease. Interaction with the host cell microfilament system, particularly actin, appears to be the basis for propelling the bacteria through the host cell cytoplasm to generate the membraneous protrusions whereby cell‐to‐cell spread occurs. The actA locus of L.monocytogenes encodes a 90 kDa polypeptide that is a key component of bacterium‐host cell microfilament interactions. Cloning of the actA gene allowed the identification of its gene product and permitted construction of an isogenic mutant strain defective in the production of the ActA polypeptide. Sequencing of the region encoding the actA gene revealed that it was located region encoding the actA gene revealed that it was located between the metalloprotease (mpl) and phosphatidylcholine‐specific phospholipase C (plcB) genes. Within the cytoplasm of the infected cells, the mutant strain grew as microcolonies, was unable to accumulate actin following escape from the phagocytic compartment and was incapable of infecting adjacent cells. It was also dramatically less virulent, demonstrating that the capacity to move intracellularly and spread intercellularly is a key determinant of L.monocytogenes virulence. Like all other virulence factors described for this microorganism, expression of the ActA polypeptide is controlled by the PrfA regulator protein. The primary sequence of this protein appeared to be unique with no extended homology to known protein sequences. However, an internal repeat sequence showed strong regional homology to a sequence from within the hinge region of the cytoskeletal protein vinculin.
Power control for two-tier femtocell networks using pricing mechanism via emergency message

This paper proposes the power control method using a pricing mechanism via emergency message to mitigate the cross-channel interference for downlink transmission in two-tier femtocell networks, where macrocell and overlaid femtocells share the same frequency band (i.e., cochannel deployment). Macrocell users measure the channel gain from base station to user, and computes the achieved SINR. If the macrocell achieved SINR is not satisfied for a target SINR, a macrocell user broadcasts emergency message to close-by femtocell users. When femtocell users receive the emergency message, the femtocell pricing coefficient value is forced to increase, which in turn decreases their power, resulting in reduced cross-channel interference at the macrocell. Consequently, the macrocell user will then satisfy the target SINR faster, but with some modest loss in total throughput.
PENGARUH ENTREPRENEURIAL ORIENTATION, CULTURE ORGANIZATION INTERNAL FACTOR TERHADAP PERFORMANCE ORGANIZATION MELALUI CORPORATE ENTREPRENUERSHIP CAPABILITY PADA UMKM BATIK TULIS DI JAWA TIMUR

This research aims to provide a paradigm change creative businessmen in order to develop business in the manage well with using some variables entrepreneurial orientation, culture organization, internal factor in increasing permormance organization through corporate entrepreneur capability and can increase the level of a large proportion of with the development of entrepreneurial character on the whole community of UMKM Batik in East Java. Researchers attempting to help to resolve the problems that the economy is still not Optimal yet on the community of UMKM Batik in East Java and an increase in the creative economy that synergy in improve business kinierja in an organization of UMKM Batik in East Java, so that the income level of UMKM Batik in the lands around East Java can rise again. Researchers took samples around 100 people entrepreneurs who have a business UMKM Batik in East Java and using the methods of quantitative analysis and using the appliance SEM AMOUS analysis and location is specified in the researchers,) is expected to found a positive result against the business development of UMKM Batik and can help the sales profit level and can improve the level of technology used by entrepreneurs and increase the level of community welfare UMKM Batik in East Java. And to increase the performance of the organization of UMKM Batik in East Java. Key Words : entrepreneurial orientation, culture organization, internal factor, permormance Organization, corporate entrepreneur capability
Cadmium, lead and mercury in human milk from Slovakia

The objective of this study was to investigate Cd, Pb, and Hg levels in the breast milk of 158 lactating healthy women who were not occupationally exposed and living in eight environmentally different polluted locations of the Slovak Republic. Levels of these metals were examined in relation to selected parameters, such as: location, mother's age, parity, number of mother's teeth fillings, newborn's gender and birth weight, and smoking habits in the family. Cd and Pb levels in human milk and reconstituted infant formula were determined by GFAAS. Hg levels were measured by amalgamation technique AAS. The average concentrations of Cd, Pb and Hg in breast milk samples, taken on the 4th postpartum day, were 0.43, 4.7 and 0.94 µg/kg, respectively, and those in infant formula (n = 10) were 0.40, 5.0 and 0.25 µg/kg, respectively. Dietary weekly intakes of Cd, Pb, and Hg from breast milk and infant formula in newborn babies were also estimated. Whereas the calculated average dietary intakes of Cd, Pb, and Hg in newborn babies from breast milk and infant formula were all far lower than the appropriate PTWI values recommended by WHO/FAO, two individual breast milk samples for Pb and one breast milk sample for Hg exceeded the PTWI values. Regarding the studied parameters, only the active/passive smoking of the mother at home significantly increased Pb levels in breast milk and amalgam teeth fillings increased Hg levels in breast milk.
Predicting structures and stabilities for H-type pseudoknots with Material Supplemental

RNA pseudoknots play a critical role in RNA-related biology from the assembly of ribosome to the regulation of viral gene expression. A predictive model for pseudoknot structure and stability is essential for understanding and designing RNA structure and function. A previous statistical mechanical theory allows us to treat canonical H-type RNA pseudoknots that contain no intervening loop between the helices (see S. Cao and S.J. Chen [2006] in Nucleic Acids Research, Vol. 34; pp. 2634–2652). Biologically significant RNA pseudoknots often contain interhelix loops. Predicting the structure and stability for such moregeneral pseudoknots remains an unsolved problem. In the present study, we develop a predictive model for pseudoknots with interhelix loops. The model gives conformational entropy, stability, and the free-energy landscape from RNA sequences. The main features of this new model are the computation of the conformational entropy and folding free-energy base on the complete conformational ensemble and rigorous treatment for the excluded volume effects. Extensive tests for the structural predictions show overall good accuracy with average sensitivity and specificity equal to 0.91 and 0.91, respectively. The theory developed here may be a solid starting point for first-principles modeling of more complex, larger RNAs.
An Evidence‐Based Structure for Transformative Nurse Executive Practice: The Model of the Interrelationship of Leadership, Environments, and Outcomes for Nurse Executives (MILE ONE)

Identifying and measuring success within the chief nurse executive (CNE) population have proven complex and challenging for nurse executive educators, policy makers, practitioners, researchers, theory developers, and their constituents. The model of the interrelationship of leadership, environments, and outcomes for nurse executives (MILE ONE) was developed using the concept of consilience (jumping together of ideas) toward limiting the ambiguity surrounding CNE success. The MILE ONE is unique in that it links existing evidence and identifies the continuous and dependent interrelationship among 3 content areas: (1) CNE; (2) nurses' professional practice and work environments; and (3) patient and organizational outcomes. The MILE ONE was developed to operationalize nurse executive influence, define measurement of CNE success, and provide a framework to articulate for patient, workforce, and organizational outcome improvement efforts. This article describes the MILE ONE and highlights the evidence base structure used in its development.
Research on Basic Theories and Methods of Conceptual Design of Mechanical Products Based on Demand Dynamics Theory

The conceptual design of mechanical products and the theoretical design theory of demand dynamics are briefly introduced. The theoretical-based design steps provided by the theoretical design of demand dynamics for the conceptual design of mechanical products are put forward, which make the design process rational. The usability of the theory of demand dynamics in the conceptual design of mechanical product modeling is discussed, and the user individual, social public group and functional technical constraint mode are summarized. This paper analyzes the guidance and convergence of demand dynamic theory in the conceptual design of mechanical product modeling. Focusing on the functional expression, functional decomposition and synthesis, functional reasoning and decision-making of intelligent conceptual design, this paper focuses on the dynamic conceptual design method of functional, principle, layout and structure requirements and the dialectical thinking process of computer simulation of human problem-solving.
A review of Kuala Lumpur International Airport (KLIA) as a competitive South-East Asia hub

This paper is aimed to determine the strengths and weaknesses of Kuala Lumpur International Airport (KUL) against its competitors in Southeast Asia countries. Due to the geographical and market relevance issues, several airport hubs around KUL are chosen for comparison: Changi International Airport (SIN), Suvarnabhumi International Airport (BKK) and Soekarno-Hatta International Airport (CGK). Strengths, weaknesses, opportunities and threats (SWOT) analysis is used to evaluate the comparative situation between the airports in relation to changing industry and market environment. The study discovers some competitive edges for KUL. Nonetheless, the airport still has to be improved to face future challenges and it is under imminent threat of new aircraft technology.
Analysis of Rural Entrepreneurship under Theoretical Approach of Resources and Capabilities: A Case of Rural Micro Business

The purpose of this document is to analyse the case of a company in venture stage, to determine the successes and failures in starting the business, based on the theory of resources and capabilities and entrepreneurship. It is intended to answer the question: what were the successes and failures visiting the entrepreneurs in running the business in the analysed case project? The analysis leads to the conclusion that empirical knowledge of the entrepreneurs, in this case, was not enough to lead this business to success and that lack of structured knowledge and adequate scientific support strongly directed this venture towards non-permanence in this market.
Knowledge Intensive Business Services (KIBS) and regional development : some implications for de-industrialised regions

In a modern, learning economy the primary task of industrial and innovation policies should be to promote innovative interactions between economic sub-systems, organisations and individuals. KIBS are particularly important in these processes, not only because of the significance of their own growth and innovativeness, but also because of their systemic role in influencing the innovation activities of client firms. A number of studies also show that the expertise provided by KIBS is associated with economic growth and can therefore be treated as a factor of production alongside capital and labour. Since most previous research has focused on globalised KIBS located in metropolitan regions, there has been a dearth of studies of KIBS SMEs located in de-industrialised regions. This thesis examines their structural role (in terms of tradability and support to customers) and their systemic role (as innovators and facilitators of knowledge and expertise across space). One of the main contributions of this research is that it improves understanding of the role KIBS play in regional economic development. The results of the survey are the key novelty as well as theoretical contribution which relates the literature on knowledge bases to KIBS. Findings indicate that in de-industrialised regions local markets constitute a more important source of demand compared to metropolitan regions such as London. In addition, the results indicate that characteristics of intermediate demand vary across different KIBS sub-sectors, with engineering KIBS being relatively more reliant on the manufacturing base. For them, further de-industrialisation may pose survival challenges and regional policies therefore need to support them through technological upgrading based on old industrial formations. The majority of KIBS depend largely on other services, hence there would seem to be a scope for devising separate, service oriented policies. For those KIBS that largely depend on government contracts and consumer demand, however, prospects remain uncertain and bleak. This research shows that KIBS innovation is supported by engagement in various external knowledge networking within and outside their respective regions but the results indicate that in order to reap the benefits form external knowledge, firms’ capacity must be built. Also, KIBS sub-sectors vary with respect to their role as knowledge agents as some are associated with the analytic knowledge base (Engineering and Architecture and R&D and Technical ) and some with the symbolic knowledge base (Computer and related and Management consultants). The issue of transferability of knowledge is particularly important for KIBS as they act as knowledge facilitators and findings suggest that some types of knowledge (e.g. analytical) are indeed easier to transfer across space. KEY WORDS: KIBS, de-industrialised regions, regional development, innovation, external knowledge, knowledge bases
Host Derived Biomarkers in Periodontitis: an Insight

A major challenge in clinical periodontics is to find a diagnostic method that could predict the active phase of the disease, severity of the disease as well as treatment outcome of the disease. To meet this challenge, the study of various Biomarkers of soft tissue and bone destruction has gained popularity. But still it is difficult to find a reliable biomarker of periodontal tissue destruction with high sensitivity, specificity and utility.
Mother recognition and preference after neonatal amygdala lesions in rhesus macaques (Macaca mulatta) raised in a semi-naturalistic environment.

Attachment to the caregiver, typically the biological mother, is crucial to young mammals' socio-emotional development. Although studies in nonprimate species suggest that the amygdala regulates social preference and attachment development, its role in primate filial attachment development has been little investigated and has produced mixed results. This study assessed the effects of neonatal amygdala- (Neo-A, N = 16) and sham- (Neo-C, N = 12) lesions on mother recognition and discrimination in macaques raised in species-typical social groups. Neonatal amygdalectomy did not affect social discriminative abilities and mother preference at 3 and 6 months of age, strongly suggesting that the amygdala is not involved in the cognitive processes underlying the development of filial attachment at least when the amygdala damage occurred after the third to fourth weeks of age. Nevertheless, as compared to sham-operated controls, amygdalectomized infants initiated physical contact with their mothers less frequently. The findings are discussed in relation to the known contribution of the amygdala to filial attachment in both rodents and humans.
Students' search process and outcome in Medline in writing an essay for a class on evidence-based medicine

Purpose – The aim of this study is to explore to which extent searching by medical students in Medline produces information items useful for writing an essay measured by precision and relative recall as perceived by the students, the proportion of cited items, and their utilization on four dimensions of the essay writing task evaluated by external assessors. It also aims to study interrelations of search process and outcome.Design/methodology/approach – The study subjects were 42 third year medical students attending a class on Diagnostic and therapy. Searching in Medline was a part of their assignment of essay writing. The data consist of students' printed logs of Medline searches, students' assessments of the usefulness of the references retrieved, a questionnaire concerning the search process, and evaluation scores of the essays given by the teachers of the class. Pearson correlation coefficients were calculated for answering the research questions.Findings – The paper finds that precision and relative.
Helicobacter pylori infection impacts on functional dyspepsia in Thailand.

BACKGROUND Helicobacter pylori (H. pylori) is a well known major cause of gastric cancer and even when asymptomatic infected patients are at elevated risk. Functional dyspepsia (FD) is also one of the most common gastrointestinal diseases, which greatly impacts the quality of life. H. pylori infection and psychosocial stress are frequently associated with FD but limited studies have confirmed the relationships, especially in Southeast Asian countries. Here we aimed to investigate the prevalence and impact of H. pylori infection, anxiety and depression on Thai FD patients. MATERIALS AND METHODS This cross-sectional study was conducted in a tertiary care center in Thailand, during February 2013-January 2014. All FD patients were diagnosed and categorized by Rome III criteria into epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS) groups. The Hospital Anxiety and Depression Scale was used to evaluate psychological status. The presence of H. pylori was defined as positive with H. pylori culture, positive rapid urease test or positive histology. RESULTS Three hundred FD patients were included, 174 (58%) female. Overall mean age was 54.8+15.1 years. There were 192 (64%) patients with PDS and 108 (36%) with EPS. H. pylori infection was demonstrated in 70 (23.3%) patients. Anxiety and depression were documented in 69 (23%) and 22 (7.3%), respectively. H. pylori infection, anxiety and depression were significantly higher in PDS than EPS patients (27.1% vs 16.7%; p=0.04; OR=1.86; 95%CI=1.01-3.53 and 29.7% vs 11.1%; p=0.0002; OR=3.4; 95%CI=1.7-7.1 and 10.4% vs 1.9%; p=0.006; OR=6.2; 95%CI=1.4-38.9, respectively). CONCLUSIONS H. pylori infection, anxiety and depression were commonly found in Thai FD patients and more prevalent in PDS than EPS. H. pylori eradication might be the key to success for the treatment of Thai FD patients and prevent the development of gastric cancer.
Bayesian Inference and Prediction in an M/G/1 with Optional Second Service

In this article, we exploit the Bayesian inference and prediction for an M/G/1 queuing model with optional second re-service. In this model, a service unit attends customers arriving following a Poisson process and demanding service according to a general distribution and some of customers need to re-service with probability “p”. First, we introduce a mixture of truncated Normal distributions on interval (− ∞, 0) to approximate the service and re-service time densities. Then, given observations of the system, we propose a Bayesian procedure based on birth-death MCMC methodology to estimate some performance measures. Finally, we apply the theories in practice by providing a numerical example based on real data which have been obtained from a hospital.
Atmospheric Methane and Nitrous Oxide of the Late Pleistocene from Antarctic Ice Cores

The European Project for Ice Coring in Antarctica Dome C ice core enables us to extend existing records of atmospheric methane (CH4) and nitrous oxide (N2O) back to 650,000 years before the present. A combined record of CH4 measured along the Dome C and the Vostok ice cores demonstrates, within the resolution of our measurements, that preindustrial concentrations over Antarctica have not exceeded 773 ± 15 ppbv (parts per billion by volume) during the past 650,000 years. Before 420,000 years ago, when interglacials were cooler, maximum CH4 concentrations were only about 600 ppbv, similar to lower Holocene values. In contrast, the N2O record shows maximum concentrations of 278 ± 7 ppbv, slightly higher than early Holocene values.
Digital Lock-In Controller IC for Optimized Operation of Resonant SCC

This paper introduces a lock-in integrated controller for resonant SCC. The controller identifies the resonant period of each sub-circuit on-the-fly and locks-in to the correct switching time to fully utilize the charge transfer rate for each flying capacitor. The various modules of the controller are detailed, including the auto-tuner and sequencer which accommodate any mismatch, variations or drifts of component values or circuit configuration. The IC has been designed and fabricated on a 0. 18µm 5V process resulting in effective silicon area of 0.64mm2. Post-layout results of the controller IC operating in closed-loop are provided, demonstrating accurate lock-in for two resonators with individual independent resonant characteristics. A full-scale hardware prototype of 650W 4:1 switched-tank-converter is used to validate the controller’s operation prior to IC fabrication, demonstrating excellent lock-in capabilities resulting in high efficiency of up to 98.6%.
Effect of Communication Failures on State Estimation of 5G-Enabled Smart Grid

Information and Communication Technologies (ICT), Wide Area Measurement Systems (WAMS) and state estimation represent the key-tools for achieving a reliable and accurate knowledge of the power grid, and represent the foundation of an information-based operation of Smart Grids. Nevertheless, ICT brings new potential vulnerabilities within the power grid operation, that need to be evaluated. The strong interdependence between power system and ICT systems requires new methodologies for modeling the smart grid as a Cyber Physical System (CPS), and finally analyzing the impact of ICT failures on the power grid operation. This paper proposes a novel methodological approach that combines Stochastic Activity Networks (SAN) modeling and numerical computation for dependability analysis of a 5G-based WAMS. Internal influences such as component failures and external influences such as rain effect are considered, and the impact of these failures are assessed over the WAMS capability to provide reliable data for performing an accurate power network state estimation. Different state estimation approaches (traditional SCADA and PMU-based algorithms) and weather conditions are compared in terms of mean states estimation error and safety. The results highlight that 5G based WAMS result in a close-to-ideal behavior which enforces the prospect of a future adoption for smart grid monitoring applications.