Miracle-dz/UniFAR-FTUs huggingface dataset:
What Clinical and Symptom Features and Comorbid Disorders Characterize Outpatients with Anxious Major Depressive Disorder: A Replication and Extension

Objective: We previously found that 46% of the first 1450 outpatients with depression participating in the multicentre Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project qualified for the designation of anxious depression. This study was designed to replicate and extend our initial findings in a subsequent, larger cohort of outpatient STAR*D participants with nonpsychotic major depressive disorder (MDD). Methods: Baseline clinical and sociodemographic data were collected on 2337 consecutive STAR*D participants. A baseline 17-item Hamilton Depression Rating Scale Anxiety-Somatization factor score of 7 or higher was designated as anxious depression. We identified concurrent Axis I disorders with the Psychiatric Diagnostic Screening Questionnaire (PDSQ), using a 90% specificity threshold. Depressive symptoms were assessed by clinical telephone interview with the 30-item Inventory of Depressive Symptomatology–Clinician-Rated (IDS-C30). Results: The prevalence of anxious depression in this population was 45.1%. Patients with anxious MDD were significantly more likely to be in primary care settings and to be women, nonsingle, unemployed, Hispanic, less educated, and suffering from severe depression, both before and after adjustment for overall depression severity. Patients with anxious depression were significantly more likely to meet PDSQ thresholds for generalized anxiety disorder, panic disorder, obsessive–compulsive disorder, posttraumatic stress disorder, agoraphobia, hypochondriasis, and somatoform disorder, both before and after adjusting for baseline depression severity. Individuals with anxious depression were also significantly less likely to endorse IDS-C30 items concerning atypical features and were significantly more likely to endorse items concerning melancholic-endogenous depression features, both before and after adjusting for baseline depression severity. Conclusions: This study clearly replicates our previous STAR*D findings and supports the notion that anxious depression may be a valid diagnostic subtype of MDD, with distinct psychiatric comorbidities and clinical and sociodemographic features.
COMPARISON OF THE CYTOGENETIC RADIOADAPTIVE RESPONSE INDUCED BY NATURAL BACKGROUND RADIATION WITH OCCUPATIONAL EXPOSURE IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES

COMPARISON OF THE CYTOGENETIC RADIOADAPTIVE RESPONSE INDUCED BY NATURAL BACKGROUND RADIATION WITH OCCUPATIONAL EXPOSURE IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES ALI SHABESTANI MONFARED ** Department of Medical Physics, Babol University of Medical Science, Babol IR-IRAN HOSSEIN MOZDARANI Department of Radiology & Radiation Biology , Tarbiat Modarres University , Tehran ,IR-IRAN MEHRANGIZ AMIRI Department of Nuclear Medicine, Babol University of Medical Sciences , Babol IR-IRAN
Flexicurity, Taxes and Job Reallocation

This paper considers the role of flexicurity when jobs must be reallocated from a declining, traditional sector to a skill intensive expanding sector. Workers initially decide whether to acquire qualifications for skill-intensive tasks or to accept a less demanding traditional job. Unemployment arises from job separation in the declining sector and difficulties in retraining for new employment in the expanding sector. The paper derives an optimal welfare policy which combines the design of the tax schedule with three pillars of ‘flexicurity’. The optimal policy includes (i) a progressive wage tax schedule; (ii) a wage subsidy to re-employed workers; (iii) unemployment insurance; (iv) moderate job protection; and (v) active labor market policy to facilitate job reallocation.
[Gender and metabolic control of type 2 diabetes among primary care patients].

INTRODUCTION removing the biological perspective of the sexual differences and understanding the asymmetries related to diabetes, lead to define situations of benefit or deterioration of the population's health. OBJECTIVE to analyze gender situations related to self-care and control of type 2 diabetes in primary care patients. METHODS we conducted a descriptive observational study in 620 patients with diabetes at the family medicine clinic number 3 of Instituto Mexicano del Seguro Social in Guadalajara, Mexico. Three groups each with 79 women and 54 men were integrated. Gender situation was valued by means of questionnaires. Data were tested using the multiple correspondences analysis in seven situations of susceptibility. The comparison included the analysis with Snedecor's F distribution and chi2. RESULTS women have several social disadvantages, deterioration of healthy life, poor self-care and lack of solidarity that increases their vulnerability to reach glycemic control successfully to avert complications. CONCLUSIONS continuing investigating about the gender situation as the main driver to design specific actions to provide integrated care, should focus to supporting women's self care in general and glycemic control of diabetic women in particular.
Human Metabolites of Cannabidiol: A Review on Their Formation, Biological Activity, and Relevance in Therapy

Abstract Cannabidiol (CBD), the main nonpsychoactive constituent of Cannabis sativa, has shown a wide range of therapeutically promising pharmacological effects either as a sole drug or in combination with other drugs in adjunctive therapy. However, the targets involved in the therapeutic effects of CBD appear to be elusive. Furthermore, scarce information is available on the biological activity of its human metabolites which, when formed in pharmacologically relevant concentration, might contribute to or even account for the observed therapeutic effects. The present overview summarizes our current knowledge on the pharmacokinetics and metabolic fate of CBD in humans, reviews studies on the biological activity of CBD metabolites either in vitro or in vivo, and discusses relevant drug–drug interactions. To facilitate further research in the area, the reported syntheses of CBD metabolites are also catalogued.
Modeling SiO2 Ion Impurities Aging in Insulated Gate Power Devices Under Temperature and Voltage Stress

This paper presents a formal computational methodology to explain how the oxide in semiconductors degrades over time and the dependence of oxide degradation on voltage and temperature stresses. The effects of aging are modeled and quantified by modification of the gate-source capacitance value. The model output is validated using experimental results of a thermally aged power semiconductor device.
Effect of SpeB and EndoS from Streptococcus pyogenes on Human Immunoglobulins

ABSTRACT Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.
The use of management accounting practices in Malaysian SMEs

There have been the recent calls for additional research in order to enhance the understanding of the adoption of management accounting practices (MAPs) in small and medium sized enterprises (SMEs). This, allied to an increasing importance of SMEs around the world especially in developing countries, is the motivation for this research. This research explores the uptake of a broad range of MAPs in Malaysian SMEs; identifies the roles of MAPs in the management of SMEs; determines factors that affect the extent of use of MAPs in SMEs and lastly examines the relationship between the use of MAPs and organizational performance of SMEs. A postal questionnaire was conducted to 1,000 Malaysian SMEs in manufacturing sector which elicited 160 useable responses. The results show that the majority of respondents have used the five management accounting areas identified. Use of the costing system, budgeting system and performance evaluation system are significantly higher than for the decision support system and strategic management accounting, which indicates that the uptake of traditional MAPs is greater than for sophisticated MAPs. The results indicate that medium sized firms make greater use of all MAPs as opposed to small sized enterprises. The most significant differences relate to the use of decision support system and strategic management accounting. The increased uptake of sophisticated MAPs by larger firms is in line with size being a contingent variable explaining the use of such practices. The results also suggest that MAPs were perceived as playing very important roles in the management of Malaysian SMEs. Performance evaluation and controlling activities were the major roles of MAPs in the management of SMEs. Overall the study suggests 4 that MAPs are perceived by SMEs as relevant and useful in their management processes. Further, the study found that four out of five contingent factors; size of the firm, intensity of market competition; participation of the owner/manager in the development of MAPs in firm and advanced manufacturing technology have a positive and statistically significant relationship with the use of certain MAPs. The research however found weak support for the positive relationship between the use of MAPs and organizational performance of SMEs. This study enriches the existing body of knowledge of management accounting by providing information as to the use of MAPs in SMEs in Malaysia. The findings can be specifically informative for policy makers intent on developing management accounting skills among Malaysian SMEs. This research will provide valuable insights into the nature of MAPs in SMEs in a developing country and will promote interest among Malaysian researchers as well as researchers of other countries to make the SME sector a focus of interest in management accounting research.
A study of the approaches and attitudes of information systems executives to measuring information systems effectiveness

The purpose of the research is to examine the attitudes of IS executives to the current and future importance of some of the approaches to measuring IS efficiency and IS effectiveness in large Australian organisations. The study identified the nature of IS effectiveness approaches along the lines of whether they are business-oriented, IS intemaVoperational, financial, quantitative or qualitative measures. It also examined whether the structure of the IS management and industry sector had an effect on attitudes towards these measures The study was initiated with a literature review of some of the measures of IS effectiveness and IS efficiency. The elements which have led to the increased importance in business-oriented measures are namely: the shift in IS management structure from centralisation to decentralisation and eventually to dispersion, and the alignment of IS strategy to business strategy. The research was based on the measurement frameworks which focus on measuring the business performance of IS. They are: -Balanced scorecard by Kaplan & Norton (1992) -Business value framework by Rubin (1991a, 1991b, 1991c) -Enterprise level measurement by Berger (1988) -Return on management by Strassmann (1990) The sample included Australia's top 200 companies by turnover. Such organisations would likely be large enough to be using computer-based products and services. The subjects were the IS managers in organisations. n
Back Pain Is Associated With Changes in Loading Pattern Throughout Forward and Backward Bending

Study Design. Experimental study to determine the kinetics of the lumbar spine (LS) and hips during forward and backward bending. Objective. To investigate the effects of back pain, with and without a positive straight leg raise (SLR) sign, on the loading patterns in the LS and hip during forward and backward bending. Summary of Background Data. Forward and backward bending are important components of many functional activities and are part of routine clinical examination. However, there is a little information about the loading patterns during forward and backward bending in people with back pain with or without a positive SLR sign. Methods. Twenty asymptomatic participants, 20 back pain participants, and 20 participants with back pain and a positive SLR sign performed 3 continuous cycles of forward and backward bending. Electromagnetic sensors were attached to body segments to measure their kinematics while 2 nonconductive force plates gathered ground reaction force data. A biomechanical model was used to determine the loading pattern in LS and hips. Results. Although the loading on the LS at the end of the range decreased significantly, the loading at the early and middle ranges of forward bending actually increased significantly in people with back pain, especially in those with positive SLR sign. This suggests that resistance to movement is significantly increased in people with back pain during this movement. Conclusion. This study suggested that it is not sufficient to study the spine at the end of range only, but a complete description of the loading patterns throughout the range is required. Although the maximum range of motion of the spine is reduced in people with back pain, there is a significant increase in the moment acting through the range, particularly in those with a positive SLR sign.
Novel Solutions for High-Speed Self-Excited Induction Generators

By taking into account technical and economic features, a brief review is presented for the basic topologies and methods of self-excited induction generators (SEIGs). Three novel solutions are described in more detail; two of them are based on resonant circuit application, the third one applies a switched condenser topology using a novel control method based on space vector (SV) theory. In these solutions, the theoretical considerations are confirmed by computer simulations and laboratory test results.
Evaluating Anthropomorphic Product Recommendation Agents: A Social Relationship Perspective to Designing Information Systems

In online shopping environments, the product-advising function originally performed by salespeople is being increasingly taken over by software-based product recommendation agents (PRAs). However, the literature has mostly focused on the functionality design and utilitarian value of such decision support systems, mostly ignoring the potential social influence they could exert on their users. The objective of this study is to apply a social relationship perspective to the design of interfaces for PRAs. We investigate the effects of applying anthropomorphic interfaces—namely, humanoid embodiment and voice output—on users' perceived social relationship with a technological and software-based artifact designed for electronic commerce contexts. The findings from a laboratory experiment indicate that using humanoid embodiment and human voice-based communication significantly influences users' perceptions of social presence, which in turn enhances users' trusting beliefs, perceptions of enjoyment, and ultimately, their intentions to use the agent as a decision aid. These results extend the applicability of theories concerning traditional shopper-salesperson relationships to customers' interactions with technological artifacts residing on Web sites—that is, the recommendation agent software—and provide practitioners with guidelines on how to design Internet stores with the goal of building social relationships with online shoppers and enhancing their overall shopping experiences.
CELEBRATING 50 YEARS OF THE APPLIED PROBABILITY TRUST

We establish a connection between epidemic models on random networks with general infection times considered in Barbour and Reinert (2013) and first passage percolation. Using techniques developed in Bhamidi, van der Hofstad and Hooghiemstra (2012), when each vertex has infinite contagious periods, we extend results on the epidemic curve in Barbour and Reinert (2013) from bounded degree graphs to general sparse random graphs with degrees having finite second moments as n → ∞, with an appropriate X2 log+ X condition. We also study the epidemic trail between the source and typical vertices in the graph.
Implementation of predictive controllers for NMAS consensus with neighhour agent delay

This paper discusses the implementation of a prediction algorithm in solving an external consensus problem for heterogeneous networked multi-agent systems (NMAS) with asymmetric network-induced communication delay. By considering different networked-induced delays for each information passing route between agents, an output predictor based on the recursive equation is developed. The developed strategy is simulated with a single-input single-output (SISO) NMAS model and validated through practical experiments with water level test rigs under intranet network connections.
Cutaneous manifestations of Gaucher disease

We reviewed the cutaneous manifestations of type I non‐neuropathic Gaucher disease in fifty South African patients. Characteristic changes such as diffuse pigmentation, easy tanning and flitting brwon macules were found to be useful pointers to the diagnosis. Other cutaneous changes secondary to infiltration of the marrow and liver were common and important findings.
The Financial Performance of Whole Company LBOs

Using the previously untapped Census Quarterly Financial Report (QFR) file, we explored the financial performance of a large unbiased sample of 209 leveraged buyouts (LBOs) and 48 going private transactions occurring between 1978 and 1989. Our principal findings are: First, we confirm previous work showing that LBOs substantially increase operating performance and reduce taxes. Second, we find that the operating performance gains are sustained for three years. However, there is a significant drop in performance in the fourth and fifth years. Performance in these years is not significantly above the pre- LBO level. Third, total debt to assets displays only a slight insignificant downward trend. Thus, high debt remains after the drop in performance. Fourth, we find evidence that the performance gains decline in the mid- to late 1980s, with the exception of 1989. Fifth, the data suggest that LBOs target typical firms. The only significant pre-LBO firm characteristic was lower bank debt relative to nonbank debt. Sixth, we identify a number of factors that differentiate LBO performance. Performance tends to be higher when pre-LBO performance is low and the firm is classified as a large R&D performer. Conversely, management buyouts and buyouts involving extensive restructuring did not outperform other buyouts. Finally, we observe a clear linkage between debt and performance, since nonleveraging going-private deals have significantly lower performance than LBOs.
Parity Waterfall method

This paper proposes a method for improvement of the fault-coverage capabilities of Field Programmable Gate Array (FPGA) designs. It utilizes Concurrent Error Detection (CED) techniques and the basic architectures of actual modern FPGAs the Look-Up Table (LUT) with two outputs. Proposed Parity Waterfall method is based on a cascade (waterfall) of several waves of inner parity generating the final parity of outputs of the whole circuit. The utilization of the (mostly) unused output of a two-output LUT allows the proposed method to cover any single possible routing or LUT fault with a small area overhead. The method is experimentally evaluated using the standard set of IWLS2005 benchmarks and using our simulator/emulator. The experimental results of the proposed parity waterfall method are compared with a similar existing technique (duplication with comparison). These results show that the area overhead is smaller than the overhead of the duplication with comparison method for all of the tested circuits and 100% fault coverage is achieved.
Backscattering Cross Section of Ultrawideband Antennas

Backscattering of ultrawideband (UWB) antennas is theoretically and experimentally studied in this letter. The finite-difference time-domain (FDTD) method using Berenger's perfectly matched layer absorbing boundary condition (PML-ABC) is employed for simulation and the measurement is carried out in indoor environment. Monostatic radar cross section (RCS) of square-slot antenna and printed circular-disc monopole antenna (PCDMA) terminated with three different kinds of loads are numerically calculated and experimentally verified. They are in good agreement in the frequency range from 3 to 11 GHz. Afterwards, scattering characteristics of the structural and antenna modes of two kinds of UWB antenna structures are extensively characterized in both the frequency domain and time domain
Determining and controlling convergence in fractal image coding

Fractal image coding, which has been used successfully for image compression, has previously found applications in other areas of image processing, such as object recognition, segmentation and contour extraction. The parameters of a fractal code determine whether or not it converges to a stable image. Methods have been proposed that predict the convergence of a fractal coding process, but to a significant degree they were dependent on the type of fractal encoding scheme used. In this paper we describe how the factors relating to convergence can be calculated for a general class of codes consisting of affine transformations. We demonstrate how it can be implemented and exploited during encoding. Consequently, this new understanding allows us to calculate and control the two factors that reflect convergence, the contractivity and eventual contractivity factors. The main theorems, and the experiments carried out to illustrate their implementation are presented here.
The microwave down converted from ultra-stable laser by an optical frequency comb

An ultra-stable microwave down converted from the ultra-stable laser directly by an optical frequency comb (OFC) is built at the National Institute of Metrology China. The repetition rate (fr) of OFC is stabilized by stabilizing the sum of the carrier envelope offset frequency (fceo) of OFC and the beating frequency between the ultra-stable laser (USL) and OFC. A current feedback with 30 kHz bandwidth and a piezoelectric transducer with 1 kHz bandwidth are applied for the frequency stabilization. The frequency jitter of the stabilized sum frequency is about 4 Hz. Though the counting of locked fr, the shifted frequency of the USL is about 2087 Hz/day. As the frequency jitter of the mixing frequency of fceo and the beating frequency between this OFC and another USL is about 10Hz, the short time stability of fr is calculated to be about 5e-14. This ultra-stable microwave will be applied as the local oscillator for NIM5 Cs fountain to improve its shorter term instability.