Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease.

To investigate the expression of human herpesvirus 8 (HHV8)-encoded proteins in the cells of primary effusion lymphoma (PEL), Kaposi's sarcoma (KS) and multicentric Castleman's disease (MCD), nine rabbit polyclonal antibodies to K2, ORF26, K8, K8.1, K10, K11, ORF59, ORF65, and ORF73 were developed. Western blot analysis in PEL cell lines (TY-1 and BCBL-1) revealed that the expression of these proteins, except ORF73 (LANA), was induced by tetradecanoylphorbol acetate (TPA) treatment, indicating that these proteins are lytic proteins. Immunofluorescence assay in primary PEL cells derived from pericardial effusion and PEL cell lines with and without TPA treatment revealed that primary PEL cells exhibited the same expression pattern as noninduced PEL cell lines, and the treatment changed localization of K8, ORF59, and ORF65 proteins. Immunohistochemistry revealed that 90% of KS spindle cells expressed the ORF73 protein, whereas a small population of KS cells expressed K8, K10, K11, ORF59, and ORF65 proteins. In MCD, ORF73, ORF59, K8, K2, and K10 proteins were expressed in the cells at mantle zone of the follicle. These data indicate that KS and PEL cells expressed predominantly latent proteins, whereas MCD expressed both latent and lytic proteins, suggesting that HHV8 plays a different role in the pathogenesis of HHV8-associated diseases.
Content Cache Placement for Scalable Video in Heterogeneous Wireless Network

To alleviate the pressure brought by the explosion of mobile video traffic on present cellular networks, small cell base stations (SBSs) with caching ability are introduced. In this letter, we consider the caching strategy of scalable video coding streaming over heterogeneous wireless network containing SBSs. We formulate an integer programming problem to minimize the average download time under the constraint of cache size at each SBS, and show that finding the optimal caching placement strategy is NP-hard. Heuristic solution was proposed based on the convex programming relaxation, which reveals the structural properties of cache allocation for each video. Simulation results demonstrate that our proposed caching strategies acquire significant performance gain compared with conventional caching policy.
Erratum

Adiponectin is a new member of adipocyte derived proteins belonging to the soluble defence collagens.1 Plasma adiponectin concentrations in obese subjects are decreased in spite of an adipose specific expression.1 More interestingly, the patients with chronic coronary artery disease exhibited lower plasma adiponectin concentrations compared to body mass index (BMI) matched control subjects.2 On the other hand, adiponectin accumulates in the vascular subendothelial space when the endothelial barrier is damaged.3 In vitro, adiponectin suppresses the expression of adhesion molecules in the vascular endothelial cells and cytokine production from macrophages.2,4 Therefore, the molecule may be involved in the inflammation and tissue repairing processes. Acute coronary syndrome is often precipitated by acute thrombosis.5 It is commonly accepted that the rupture or the erosion of plaques by the inflammatory process leads to coronary thrombosis and acute myocardial infarction (AMI). The C reactive protein (CRP) concentrations in the acute phase are suggested to reflect pre-existing coronary plaque instability associated with the onset of AMI. The significance of adiponectin in acute coronary syndrome has never been investigated. In the present study, we examined the serial change in plasma adiponectin concentrations and its relation to plasma CRP concentration in …
Intuitive Multi-touch User Interface for Visualization of and Interaction with Product and Process Information to Enhance Product Lifecycle Management

Today’s products more and more turn into systems which are built up of different kinds of linked components that communicate among each other. The resulting complexity brings today’s information management technologies, user interfaces and information visualizations to their limits. This paper presents a research idea which proposes the use of modern touch devices with multi-touch multi-user enabled graphical user interfaces in order to handle the named complexity explosion in a new and better way.
Offspring sex ratios and the causes of placental pathology: the case of placental abruption.

Many disorders of pregnancy are associated with skewed offspring sex ratios (proportions of males). Significant excesses of boys are associated with abruptio placenta, placenta praevia, fatty liver of pregnancy and pre-eclampsia: significant excesses of girls are associated with placenta accreta and extra-uterine pregnancy (James, 1995). The causes of these sex ratio skews are not established. However I have hypothesized that maternal hormone concentrations around the time of conception causally affect the sex of the resulting offspring, high concentrations of oestrogen being associated with boys, and low concentrations with girls (James, 1996). So I suggested that each of these characteristic sex ratios is partially caused by a distinct hormone profile which is also partially responsible for the later associated pathology (James, 1995). In that paper I adduced further external evidence to support the notions that high oestrogen concentrations are partially responsible for placenta praevia, pre-eclampsia and fatty liver of pregnancy: and that low concentrations of oestrogen are associated with placenta accreta and extrauterine pregnancy. A similar argument was used to devise a testable endocrine explanation of the excess of daughters associated with hyperemesis gravidarum (James, 2001). Though I cited data on the (high) offspring sex ratio
The Show-Up Identification Procedure: A Literature Review

A show-up is an identification procedure that only presents the witness with one suspect in contrast to a lineup where the suspect is presented among a number of fillers (i.e., known innocent people). This feature makes the show-up procedure very suggestive. In this literature review, an overview of the current research about this identification procedure is presented. The different factors that influence the accuracy in show-up procedures are separated into system (e.g., clothing bias, instruction bias, and the impact of multiple show-ups) and estimator variables (e.g., age, cross-race effects, and alcohol) in line with Wells [1]. The implications of the research are discussed together with suggestions for future research.
A mismatch in the human realism of face and voice produces an uncanny valley

The uncanny valley has become synonymous with the uneasy feeling of viewing an animated character or robot that looks imperfectly human. Although previous uncanny valley experiments have focused on relations among a character's visual elements, the current experiment examines whether a mismatch in the human realism of a character's face and voice causes it to be evaluated as eerie. The results support this hypothesis.
Normal nasal mucociliary clearance in CF children: evidence against a CFTR‐related defect

Studies on mucociliary clearance (MCC) in cystic fibrosis (CF) have produced conflicting results. This study aimed to differentiate primary (ion transport-related) from secondary (inflammatory) causes of delayed MCC in CF. Nasal MCC was measured in 50 children (CF, primary ciliary dyskinesia (PCD) and no respiratory disease). Nasal lavage fluid was analysed for interleukin (IL)‐8 and tumour necrosis factor‐α. Similar measurements were obtained in adult CF patients with and without chronic sinusitis (CS). Children with CF had neither delayed MCC nor increased levels of cytokines. Conversely, children with PCD had prolonged MCC times (all >30 min) and significantly raised levels of IL‐8. CS‐positive CF adults had significantly slower MCC than CS‐negative subjects, but IL‐8 levels were low and similar in both groups. Decreased airway surface liquid and delayed mucociliary clearance are the postulated primary mechanisms in cystic fibrosis. However, the current study reports that cystic fibrosis children have normal nasal mucociliary clearance. Abnormalities appeared in cystic fibrosis adults with symptoms of chronic sinus disease, suggesting a secondary rather than primary phenomenon. Studies to explore this mechanism in the distal, more sparsely-ciliated airways could aid an understanding of pathogenesis and the development of new treatments.
Articular aging and osteoarthrosis in dwarf mice.

In aging hypopituitary dwarf mice (dwdw), articular chondrocytes are poorly supplied with organelles; aggregation of collagen in the cartilaginous matrix is decreased, and aging of the articular cartilage is retarded as compared to non-dwarf mice (Dwdw or DwDw) of the same strain. Osteoarthrosis developing in 58% of male and in 22 % of female non-dwarfs was not observed in dwarfs regardless of sex. The unusually long life span of dwarf mice suggests that in hypopituitarism aging of non-skeletal tissues is likewise retarded.
Electrophysiological effects of electrode pull-back in cochlear implant surgery

Conclusion. The surgical technique of electrode pull-back had a significant improving effect on the spread of excitation (SOE). However, the long-term clinical and audiological outcome of this modified surgical technique should be a subject of further studies. Objective. To observe the intraoperative electrophysiological effects of a surgical electrode insertion technique (i.e. pull-back) in cochlear implantation. Patients and methods. The influence of the pull-back technique on intraoperatively recorded electrophysiological parameters (including T-NRT, ECAP amplitude, SOE) was investigated in a prospective, non-randomized, intraoperative study. In addition, we observed the correlation of insertion depth and SOE differences after a controlled electrode pull-back. We implanted 13 patients (aged 18–76 years) with a Nucleus 24CI RE cochlear implant with a perimodiolar electrode. Results. After a controlled pull-back, a significant decrease of the SOE at different electrodes (upon recording from electrodes 5, 10, 15) was observed. Electrode 10 was the SOE area with the most significant and homogeneous changes after pull-back. The change in the ECAP amplitudes was highly variable in correlation with the changes in the SOE.
Computing All Solutions of Nash Equilibrium Problems with Discrete Strategy Sets

The Nash equilibrium problem is a widely used tool to model non-cooperative games. Many solution methods have been proposed in the literature to compute solutions of Nash equilibrium problems with continuous strategy sets, but, besides some specific methods for some particular applications, there are no general algorithms to compute solutions of Nash equilibrium problems in which the strategy set of each player is assumed to be discrete. We define a branching method to compute the whole solution set of Nash equilibrium problems with discrete strategy sets. This method is equipped with a procedure that, by fixing variables, effectively prunes the branches of the search tree. Furthermore, we propose a preliminary procedure that by shrinking the feasible set improves the performances of the branching method when tackling a particular class of problems. Moreover, we prove existence of equilibria and we propose an extremely fast Jacobi-type method which leads to one equilibrium for a new class of Nash equilibrium problems with discrete strategy sets. Our numerical results show that all proposed algorithms work very well in practice.
Multidetector CT Patterns of Peritoneal Involvement in Patients with Abdominopelvic Malignancies.

OBJECTIVE To determine the patterns of peritoneal involvement in patients with abdominopelvic malignancies. STUDY DESIGN Retrospective observational study. PLACE AND DURATION OF STUDY Shifa International Hospital, Islamabad, Pakistan, from May 2004 to May 2012. METHODOLOGY Two hundred and three patients with histopathologically proven abdominopelvic malignancies with peritoneal involvement who underwent contrast-enhanced CT abdomen and pelvis were identified through electronic data base system and were included in this study after ethical committee approval. Peritoneal disease pattern, predominant sites of involvement and associated findings of ascites, lymph nodes and metastasis were assessed. Patients with tuberculosis and lymphoproliferative disorders were excluded. RESULTS The malignancies showing peritoneal involvement, in decreasing order of frequency, were ovarian cancer (n=118), colorectal cancer (n=45), pancreatic cancer (n=11), gastric cancer (n=7), endometrial cancer (n=6), gallbladder/ cholangio-carcinoma and hepatocellular cancer (n=5 each), cervical cancer (n=3), renal cell carcinoma (n=2) and transitional cell urinary bladder cancer (n=1). The most common pattern of peritoneal involvement was mixed in 79 patients (39%), omental caking in 74 patients (37%) and nodular deposits in 50 patients (24%). The most common sites of peritoneal involvement were pelvic peritoneum followed by greater omentum. CONCLUSION Peritoneal involvement is the commonest with ovarian and colorectal carcinoma. Mixed pattern of peritoneal disease was most frequently seen in these patients followed by omental caking and nodular peritoneal deposits.
A new realization for multiprocessor implementation of 2-D denominator-separable digital filters for real-time processing

An efficient multiprocessor implementation of 2D denominator-separable digital filters for real-time processing is presented. The realization is derived by minimizing the throughput delay and maximizing the parallelism using the basic primitive structure of M.Y. Dabbagh and W.E. Alexander (see ibid. vol.37, no.6, p.872-81, 1989). The proposed realization is as good and efficient as their realizations for the implementation of symmetric fan filters. It is shown that in special cases the proposed realization may be more efficient. >
Acremonium Species Combined with Penicillium Species Infection in Hip Hemiarthroplasty: A Case Report and Literature Review

Objective To illustrate that Acremonium and Penicillium species are being increasingly recognised in periprosthetic joint infections (PJIs). Case Report A 47-year-old male with liver cirrhosis and bilateral hip hemiarthroplasties complained of persistent right hip pain. Bone scan was suspicious for right hip septic arthritis. Laboratory studies revealed an elevated erythrocyte sedimentation rate (ESR; 127 mm/h) and C-reactive protein (CRP; 16.171 mg/L). At surgery caseous necrosis with a yellowish appearance around the hip was noted. Intraoperative cultures were positive for Acremonium and Penicillium species 2 weeks after inoculation. After 4 months of fluconazole monotherapy a successful revision right total hip arthroplasty was performed, the patient is walking without assistance at 1 year after surgery. Conclusions We reported a prosthetic hip infection due to Acremonium and Penicillium species. Removal of the prosthesis, antifungal therapy, and re-implantation after 4 months were successful.
Optimal Power Allocation for Wideband Cognitive Radio Networks Employing SC-FDMA

In this paper, we investigate the optimal power allocation (OPA) strategy of secondary user (SU) transmitters in wideband cognitive radio networks employing single-carrier frequency-division multiple access (SC-FDMA). To protect the link of the primary user, we study two types of constraints on the SUs: Individual per-tone interference power constraints (IPCs) for each SU and a joint aggregate IPC across all frequency tones and users. Using tools from convex optimization, we derive the sum rate optimal OPA across frequency tones for the SU transmitters for both types of constraints. Simulation results show that the proposed OPA schemes can considerably improve the achievable sum rate of SC-FDMA based SU systems compared to equal power allocation and conventional power allocation schemes.
Enabling integrated decision making for electronic commerce by modelling an enterprise's sharable knowledge

A key benefit of advances in information technology has been the increased ability to make decisions that integrate different perspectives. Enterprise resource planning software integrates information from traditionally disparate parts of the same organization. Search engines and Internet services allow a user to integrate information from sources all over the world. So what kind of integrated decisions can the e‐commerce supplier or customer make? From a technological perspective, the answer to this question depends on the following: how a given organization presents its information to others, and how it finds the right information from others. A useful tool for e‐commerce suppliers and customers to make integrated decisions is an enterprise model, a computational model of the knowledge about an enterprise – its products, processes, organizational structures, resources, goals, and constraints. Sharable knowledge, once organized and represented in an enterprise model, can then be integrated by the modelle.
Inhibitory Cross-talk between STAT5b and Liver Nuclear Factor HNF3β

STAT5b is repeatedly activated in rodent liver by the male pattern of intermittent plasma growth hormone (GH) stimulation and is required to maintain the GH pulse-regulated, male-specific pattern of liver gene expression. We presently investigate the interactions between STAT5b and hepatocyte-enriched nuclear factors (HNFs) that contribute to regulation of GH pulse-inducible, male-specific liver cytochrome P-450 (CYP) genes. STAT5 binding sites were identified in the 5′-flank of the adult male-expressed genesCYP2A2 (nucleotides −2255 to −2247), CYP4A2(nucleotides −1872 to −1864), and CYP2C11 (nucleotides −1150 to −1142). STAT5-DNA complexes were formed by eachCYP sequence with nuclear extract from GH pulse-activated male, but not female, rat liver. TheCYP2C11 STAT5 site, which is flanked by HNF3 consensus sequences, conferred STAT5b-inducible reporter gene activity in GH-treated HepG2 cells. trans-Activation of the intactCYP2C11 promoter (1.8-kilobase 5′-flank) was strongly induced by the liver nuclear factors HNF1α and HNF3β but, unexpectedly, was inhibited by GH-activated STAT5b. This STAT5b inhibitory effect could be reversed by HNF1α and reflects a functional antagonism between STAT5b and HNF3β, as evidenced by the inhibition of HNF3β DNA binding and transcriptional activity by STAT5b. HNF3β, in turn, inhibited STAT5b by a novel mechanism that leads to suppression of GH-inducible STAT5b tyrosine phosphorylation, DNA binding activity, and transcriptional activity. The potential for GH-activated STAT5b to stimulate male-specific liver CYPexpression can thus be modulated by HNF3β, highlighting the complex interrelationship between STAT5b and liver transcription factors controlling expression of GH-regulated CYPgenes.
Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures: A Prospective, Controlled, Randomized Study of Four Hundred and Fifty Patients

Background: The treatment of open fractures of the tibial shaft is often complicated by delayed union and nonunion. The objective of this study was to evaluate the safety and efficacy of the use of recombinant human bone morphogenetic protein-2 (rhBMP-2; dibotermin alfa) to accelerate healing of open tibial shaft fractures and to reduce the need for secondary intervention.Methods: In a prospective, randomized, controlled, single-blind study, 450 patients with an open tibial fracture were randomized to receive either the standard of care (intramedullary nail fixation and routine soft-tissue management [the control group]), the standard of care and an implant containing 0.75 mg/mL of rhBMP-2 (total dose of 6 mg), or the standard of care and an implant containing 1.50 mg/mL of rhBMP-2 (total dose of 12 mg). The rhBMP-2 implant (rhBMP-2 applied to an absorbable collagen sponge) was placed over the fracture at the time of definitive wound closure. Randomization was stratified by the severity of the open wound. The primary outcome measure was the proportion of patients requiring secondary intervention because of delayed union or nonunion within twelve months postoperatively.Results: Four hundred and twenty-one (94%) of the patients were available for the twelve-month follow-up. The 1.50-mg/mL rhBMP-2 group had a 44% reduction in the risk of failure (i.e., secondary intervention because of delayed union; relative risk = 0.56; 95% confidence interval = 0.40 to 0.78; pairwise p = 0.0005), significantly fewer invasive interventions (e.g., bone-grafting and nail exchange; p = 0.0264), and significantly faster fracture-healing (p = 0.0022) than did the control patients. Significantly more patients treated with 1.50 mg/mL of rhBMP-2 had healing of the fracture at the postoperative visits from ten weeks through twelve months (p = 0.0008). Compared with the control patients, those treated with 1.50 mg/mL of rhBMP-2 also had significantly fewer hardware failures (p = 0.0174), fewer infections (in association with Gustilo-Anderson type-III injuries; p = 0.0219), and faster wound-healing (83% compared with 65% had wound-healing at six weeks; p =0.0010). Conclusions: The rhBMP-2 implant was safe and, when 1.50 mg/mL was used, significantly superior to the standard of care in reducing the frequency of secondary interventions and the overall invasiveness of the procedures, accelerating fracture and wound-healing, and reducing the infection rate in patients with an open fracture of the tibia.
Use of 3G mobile phone links for teleconsultation between a moving ambulance and a hospital base station

We developed a mobile teleconsultation system based on third-generation mobile phone links. The system comprised a laptop computer and a digital camcorder. It was installed inside an ambulance to allow video-conferencing between the moving vehicle and a doctor at a base station. In addition to video and voice, high-quality still images could also be transmitted. A series of 17 trial runs with real ambulance patients was conducted in the city of Athens. In general, the videoconferencing sessions produced relatively clear video. The bandwidth was high enough for a satisfactory video of 10–15 frames/s. During a total testing period of 23 h and in an area of about 180 km2, there were nine instances of signal loss, amounting to a total of 17 min. The general opinion formed by the doctors was that the system produced good results. All initial diagnoses made using the system agreed with the final diagnoses of the patients. The study showed that the mobile system could reduce the time before an ambulance patient is seen by a doctor.
Extremely Low Birthweight Infants: Issues Related to Growth

While survival rates are increasing in the extremely low birthweight (ELBW) group of preterm infants, the most common morbidity among these infants is inadequate growth. By the time of discharge from the neonatal intensive care unit, many ELBW infants develop extrauterine growth restriction. Several issues related to improving the growth of ELBW infants, including defining adequate growth and developing evidence-based nutritional strategies, are discussed in this article. Suggestions for future research are also presented.
Enhancing lookup performance of key-value stores using cuckoo hashing

Recently, many studies have been conducted on key-value store as a platform for distributed storage services. A key-value store manages data as key-value pairs using hash tables. In this paper, we propose a hybrid hash table management technique to improve the performance of single nodes in a key-value store. The proposed scheme uses cuckoo hashing and separate chaining at the same time. Using this hybrid hashing scheme, cuckoo hashing and separate chaining offset the respective disadvantages while preserving the advantages of both. Experiments show that the proposed scheme is much faster than the hash table with separate chaining for temporal locality workloads.