Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Bioelectric Mechanisms and Functional Significance of Peripheral and Central Entrainment by Respiration

The human organism is a complex biological system with emergent properties that arise from the unified functional interactions among its diverse components. When studying the brain and body in light of modern biological systems approaches, one must analyze them in a holistic manner, putting aside reductionist models in order to understand how certain properties manifest from complex system interactions. The respiratory system is capable of continuously adapting to changes in the internal and external environment, making it one of the most integrated of physiological processes. We propose an additional respiratory process: respiration-derived electrical currents during inspiration that spread throughout the entire body maintaining homeostasis through entraining oscillatory activity, modulating cognitive processes, and modulating the autonomic nervous system. If these currents are indeed created in part from redox reactions occurring on a massive scale, then we assert they are a major aspect of an embodied cognitive framework. We propose that this potentially major source of organism integrity has been overlooked, and its application to medicine could drastically change how we understand human physiology, the autonomic nervous system, and the therapeutic treatment of various clinical disorders.
Smart Water Measurements: Literature Review

The rise of the global population and the limited availability of fresh water are key issues of public concern over water availability, water quality, failing water infrastructures, and overall water management complexity. As a result, the market for safe, available water and for the infrastructure and technologies that treat and transport water is expected to grow rapidly as stakeholders look for new solutions and approaches to integrated water resource management. The adoption and integration of ICT to the water sector is one viable solution for a better decision support and improved productivity. Smart water systems apply ICT to deliver solutions to numerous water-related issues that are currently handled inadequately by inefficient and often manual processes. For example, these systems can remotely and continuously monitor (hydraulic and water quality), report water consumption, and diagnose problems (leakage and burst detections); pre-emptively prioritize and manage maintenance issues, and remotely control and optimize all aspects of the water distribution network using data-driven insights. They can also be used to provide water customers with the information and tools they need to make informed choices about their behaviors and water usage patterns, and to comply transparently and confidently with regulatory and policy requirements on water quality and conservation [1].
Efficacy of Statistical Sampling on Contemporary Workloads: The Case of SPEC CPU2017

New benchmark suites are constantly being released, with each one providing a much larger set of benchmarks, representing an ever-growing variety of workloads. Contemporary workloads are increasingly more complex in their computational and memory footprints. Most computer architecture research is based on the ability of researchers to simulate novel ideas with a variety of workloads representing the domain being researched. However, bigger and complex benchmarks suites have made it extremely impractical to simulate complete benchmarks from start to finish. As a result, architects are becoming increasingly dependent on statistical sampling techniques like SimPoints, which identify long, repetitive execution phases in benchmarks, and limit simulations to a few instances of these phases. These techniques present an inherent trade-off between simulation speed and accuracy. This work presents results and insights for determining the accuracy of simulation points for the SPEC CPU2017 suite, using Pin and PinPoints, which is an implementation of SimPoints for the x86 ISA. Our analysis concludes that carefully chosen simulation points faithfully represent the workload; we observe <1% variance in the instruction distribution between full runs and the ones using SimPoints, while reducing simulation time by ~750x. We also show that on average, just 12 phases can faithfully represent the 90th percentile of a benchmark's behavior, which can help reduce the overall simulation time by up to ~1297x. In addition, using performance statistics with native binaries on real hardware and from an architectural model of the same machine using SimPoints, we report good co-relations between the two on metrics such as CPI. Finally, we present cases like memory hierarchy explorations, where SimPoints should be used judiciously and with extreme caution in order to derive correct conclusions - inappropriately chosen SimPoint configurations can show large deviations in memory hierarchy behavior as compared to full runs, as reported by prior studies.
The Local Becomes Global Becomes Local : The International Movement of Capital and its Urban Reifications

The object of this article is to examine fusions of the local with the global for the intangible movement of capital, and to highlight some of the processes which bring it about. In the first part of the article the mediation between space and local place is interpreted through processes of disembedding, phantasmagoria, and fusion, which are made possible through transportation and telecommunications technologies. In the second part of the article the fusion of increased global flows of capital with local urban scenes are discussed through aspects of location, specialization, expansion, and homogenization.
Prognostic value of ERCC 1 and RRM 1 in NSCLC patients with smoking history or not

Introduction: We aimed to assess the expression of ERCC1 and RRM1 in NSCLC patients with smoking history or not and investigate the therapeutic effect of biomarker-guided chemotherapy in those patients. Patients and methods: A total of 131 NSCLC patients at stage IIIb or IV were enrolled and divided into two groups based on their smoking history. Group A were smokers (n=67); Group B were non-smokers (n=64). The expression of ERCC1 and RRM1 were determined by real-time polymerase chain reaction analysis (RT-PCR). Clinicopathological characteristics, tumor response and patient survival were monitored for both groups. Results: In our study, the expression of ERCC1 was significantly higher in smoking patients as compared with non-smoking group (P=0.028). Patients’ characteristics in both groups were compared and there were no significant difference in patients age, tumor size or pathological types, but more male patients were occurred in Group A (P=0.001). Notably, the patients with low mRNA expression of ERCC1 (χ2=6.194, P=0.013) and RRM1 (χ2=5.012, P=0.025) were more sensitive to chemotherapy than patients with high expression levels. Compared with Group A, the patients in Group B displayed a higher response rate (59.3% vs. 32.8%; P=0.045), a lower 1-year recurrent rate (25.0% vs. 52.2%; P=0.001), a longer median progression-free survival (PFS) time (12.0 months vs. 14.1 months, P=0.008) and median overall survival (OS) time (22.9 months vs. 27.6 months; P=0.005). Conclusion: In summary, the expression levels of ERCC1 and RRM1 are mediated by smoking and correlated with the sensitivity to chemotherapy together with the clinical outcome of NSCLC patients. Our study suggests the adverse effect of smoking on the prognosis of NSCLC patients.
PR ] 2 5 Fe b 20 19 Extremes of Spherical Fractional Brownian Motion

Let {Bβ(x), x ∈ SN} be a fractional Brownian motion on the N -dimensional unit sphere S with Hurst index β. We study the excursion probability P {supx∈T Bβ(x) > u} and obtain the asymptotics as u → ∞, where T can be the entire sphere S or a geodesic disc on S .
Study of the rheological properties of the retropulsive jet build by the antral contraction wave in a simplified artificial stomach

The digestion of food is a process composed of different phases. A better knowledge of the entire process allows to design tailor made foods. This study is focused on the retropulsive jet generated by the contractions of the stomach and the impact of this flow field to the disintegration of the food. The antral contraction wave is moving at a constant speed toward the pylorus and shrinks at the same time. A prototype of a stomach was built to mimic the displacement of these contractions, in a simpler way. The flow field in the prototype was measured by UVP and compared with numerical simulations. Then, the simulations were used to compute the local stress applied on the fluid. Experiments with Newtonian fluids and two contractions with relative occlusions (RO) of 0.6 and 0.75 shown good agreement with the simulations. The elongation rate was higher with a RO of 0.75. A higher translation speed of the contraction (RO=0.6) allowed to increase the elongation rate.
High-pressure studies with x-rays using diamond anvil cells

Pressure profoundly alters all states of matter. The symbiotic development of ultrahighpressure diamond anvil cells, to compress samples to sustainable multi-megabar pressures; and synchrotron x-ray techniques, to probe materials’ properties in situ, has enabled the exploration of rich high-pressure (HP) science. In this article, we first introduce the essential concept of diamond anvil cell technology, together with recent developments and its integration with other extreme environments. We then provide an overview of the latest developments in HP synchrotron techniques, their applications, and current problems, followed by a discussion of HP scientific studies using x-rays in the key multidisciplinary fields. These HP studies include: HP x-ray emission spectroscopy, which provides information on the filled electronic states of HP samples; HP x-ray Raman spectroscopy, which probes the HP chemical bonding changes of light elements; HP electronic inelastic x-ray scattering spectroscopy, which accesses high energy electronic phenomena, including electronic band structure, Fermi surface, excitons, plasmons, and their dispersions; HP resonant inelastic x-ray scattering spectroscopy, which probes shallow core excitations, multiplet structures, and spin-resolved electronic structure; HP nuclear resonant x-ray spectroscopy, which provides phonon densities of state and time-resolved Mössbauer information; HP x-ray imaging, which provides information on hierarchical structures, dynamic processes, and internal strains; HP x-ray diffraction, which determines the fundamental structures and densities of singlecrystal, polycrystalline, nanocrystalline, and non-crystalline materials; and HP radial x-ray diffraction, which yields deviatoric, elastic and rheological information. Integrating these tools with hydrostatic or uniaxial pressure media, laser and resistive heating, and cryogenic cooling, has enabled investigations of the structural, vibrational, electronic, and magnetic properties of materials over a wide range of pressure-temperature conditions.
Toxicological , Phytochemical and Antioxidant Activity Evaluation of Nemalionopsis shawii Skuja from Thailand

The freshwater red alga Nemalionopsis shawii, is attached on the rocks in shallow stream located various places in Thailand. Pharmacological studies have not been investigated the toxic and biological activities for utilization. Therefore, the objectives were to examine acute toxicity, total phenolic, flavonoid contents and antioxidant activity. The crude extracts were tested for DPPH scavenging activity antioxidant activities, total phenolic content (TPC) and flavonoid contents (FC) were investigated by using Folin-Cioealteu and colorimetric aluminum chloride assays, respectively. Acute toxicity was tested with a single oral administration of the extract at a dose of 2 and 5 g kg body weight. Mortality, behavior, amount of food intake, body weight, and any abnormalities of the visceral organs, were observed. The result showed that, the extract caused neither mortality, nor abnormalities. The Nemalionopsis shawii extracted shown the antioxidant activities in all extracts. The highest TPC, FC and DPPH were in ethyl acetate (20.967 ± 0.677 mgGAEg extract, 58.326+0.857 mg QE gextract and IC50 = 0.408+0.025 mg mL ,respectively). The total phenolic and flavonoid contents in the extracts were determined and correlated with the antioxidant activity. Results suggested that this algae possess antioxiant potential which could be considered for future applications in dietary supplements or cosmetics industries.
Population Size , Pollinator Limitation , and Seed Set in the Self-Incompatible

In reward-producing animal-pollinated plants, small populations are likely to be less attractive to pollinators than large populations. The likelihood of pollinator limitation of seed production should therefore increase with decreasing population size. I documented the number of flowering plants and plant fecundity in 18 populations of the self-incompatible, tristylous herb Lythrum salicaria within an archipelago in northern Sweden in two consecutive years. To test the hypothesis that a positive correlation between population size and seed set is due to a higher degree of pollinator limitation in small than in large populations, I performed supplemental hand-pollinations in eight (1993) and 13 (1994) of the study populations. To test the hypothesis that common mating types are more likely than rare types to experience inadequate pollination, I compared the natural level of seed production and the effect of supplemental pollination in different style morphs in the five populations in which -10 plants per morph were included in the experiment. There was no significant correlation between population size and plant size in terms of number of floral shoots or number of flower-producing leaf nodes per shoot. However, there was a positive relationship between population size and seed production per flower and between population size and total seed number per plant. In contrast, there was no significant correlation between population size and seed production of flowers that had received supplemental pollination. In both years, the difference in mean seed production per flower between hand-pollinated flowers and controls decreased with increasing population size. In two of five populations, the effect of supplemental pollination differed significantly among morphs. Seed production was more likely to be pollinator limited in long-styled than in short-styled plants, but this difference could not be attributed to a preponderance of the long-styled morph in the studied populations. Results of the supplemental handpollinations indicate that the positive correlation between population size and seed production is a function of insufficient pollen transfer in small populations. Additional demographic studies are needed to determine to what extent the reduced level of seed production in small populations limits the growth of young populations, and to what extent it may threaten the local persistence of L. salicaria.
Message Quality and Congruency 1 Understanding How Tailored Communications Work : The Effects of Message Quality and Congruency on Perceptions of Health Messages

Recent research has documented the effectiveness of tailoring health behavior change messages to characteristics of the recipients, but little is known about the processes underlying these effects. Drawing from the Elaboration Likelihood Model (Petty & Cacioppo, 1986), we examined the role of message scrutiny in moderating the congruency effect (Mann, Sherman, & Updegraff, 2004). 136 undergraduate participants read either a strong or weak message promoting regular dental flossing with a frame (gain v. loss) that either matched or mismatched their motivational orientation (approach v. avoidance). Results showed that participants were sensitive to argument quality in the matched but not mismatched conditions. Further, argument quality moderated the effect of congruency on participants’ attitudes and perceived norms regarding flossing, as well as their subsequent self-reported flossing behavior. Results suggest that increased message scrutiny underlies message tailoring effects. (135 words)
Study on Evolution Mechanism of Logistics System Based on Multi-Agent

In order to improve business collaboration between enterprises and enhances the sustainable competitiveness of the logistics system, according to the features of autonomy and distribution of members in the system, a kind of architecture for logistics system based on Multi-agents is presented. And the evolution mechanisms, such as individual growth, entity assessment mechanism and cooperation mode, are also researched.
Intraoral Mikulic Pads : An Uncommon Reason for Negative Pressure Pulmonary Edema

DOI: 10.4328/JCAM.3191 Received: 28.12. 2014 Accepted: 07.01. 2015 Publihed Online: 08.01. 2015 Corresponding Author: Mustafa Ozgur, Anesthesiology and Reanimation, Antakya State Hospital, 31100, Hatay, Turkey. GSM: +905052293251 F. : +903262856020 E-Mail: mustafazgr75@gmail.com Özet Negatif basınçlı akciğer ödemi (NBAÖ), ekstübasyon sonrası üst hava yolu obstrüksiyonuna bağlı olarak gelişen nadir fakat ölümcül olabilen bir komplikasyondur. NBPÖ’nün en sık nedeni laringospazmdır. Krup, epiglottit, üst solunum yolu tümörleri, yabancı cisim aspirasyonları, koyu trakeal sekresyonlar, endotrakeal tüpü ısırma ve hematom gibi çeşitli nedenlerle olabilmektedir. Bu olgu sunumunda genel anestezi sonrası üst hava yolu obtsrüksiyonunun nadir bir nedeni olan ve operasyon esnasında ağız içine konan mikuliç tamponuna bağlı olarak gelişen NBAÖ’ini sunmayı amaçladık.
COORDINATION AS THE CHALLENGE OF DISTRIBUTED SOFTWARE DEVELOPMENT

This paper takes the position that coordination is the key challenge of the organisation of distributed software development. Based on distributed-, organisationaland software-based parameters, the paper presents an analysis of the mutual shaping between these parameters and coordination. The paper follows the analysis with tentative theoretical speculations of the potentialities of the complexities inherent in the mutual shaping; and argues for research efforts on distributed software development to be directed at the coordination challenge.
OF CERIUM NANOPARTICLES USE IN AGRICULTURE

In recent years, nanotechnology wins key positions in various fields of knowledge thanks to the special provisions with nanoparticles, namely their size and physicochemical properties. High ability of metal nanoparticles to accumulate leads to their accumulation in plant and animal organisms by increasing the bioavailability, overcoming biobarriers, tying together nucleic acids and proteins. The accumulation features of nanoparticles of metals in plants, the impact on germination and vegetation, metabolism and productivity are researched in the article. Data on the use of metal nanoparticles in animal feed as an antibiotics alternative to increase productivity are analyzed. It is established that the rare earth elements may intensify the exchange of proteins and other nutrients by stimulating hormones activity inducing the synthesis of metallothioneins and growing conversion ratio feed. The changes of prooxidant-oxidant status of animal blood by the use of drugs with nanoparticles of cerium dioxide and changes of homeostasis are established. The use of rare earth elements is positive for poultry egg production because of egg production intensification, their weight and rate of fertilization of eggs for hatching. The influence of nanoparticles on metal redox potential and processes of lipid peroxidation in animals is established. Nanodispersed ceria use as a promising nanobiomaterial for biological and medical applications and the need for further research to study all possible mechanisms of its biological activity are argued.
Wine in the blood ? Explaining French Wine Exports : Gravity , Preferences and Genetics

This good is all the more interesting as the great diversity of French wine production, from low quality to fine wines, may help to test whether gravity-laws of trade apply uniformly or are altered for high-end products in this industry. For this investigation, we exploit a unique dataset on wine shipments in volume of almost 160 different types of French wines to the 27 main importing countries between 1998 and 2015.
Title Modeling the Adaptive Role of Negative Signaling in Honey Bee Intraspecific Competition Permalink

Collective decision making in the social insects often proceeds via feedback cycles based on positive signaling. Negative signals have, however, been found in a few contexts in which costs exist for paying attention to no longer useful information. Here we incorporate new research on the specificity and context of the negative stop signal into an agent based model of honey bee foraging to explore the adaptive basis of negative signaling in the dance language. Our work suggests that the stop signal, by acting as a counterbalance to the waggle dance, allows colonies to rapidly shut down attacks on other colonies. This could be a key adaptation, as the costs of attacking a colony strong enough to defend itself are significant.
Sensitivity Analysis of Non-linear Steep Waves using VOF Method

The analysis and prediction of non-linear waves is a crucial part of ocean hydrodynamics. Sea waves are typically non-linear in nature, and whilst models exist to predict their behavior, limits exist in their applicability. In practice, as the waves become increasingly steeper, they approach a point beyond which the wave integrity cannot be maintained, and they 'break'. Understanding the limits of available models as waves approach these break conditions can significantly help to improve the accuracy of their potential impact in the field. Moreover, inaccurate modeling of wave kinematics can result in erroneous hydrodynamic forces being predicted. This paper investigates the sensitivity of non-linear wave modeling from both an analytical and a numerical perspective. Using a Volume of Fluid (VOF) method, coupled with the Open Channel Flow module in ANSYS Fluent, sensitivity studies are performed for a variety of non-linear wave scenarios with high steepness and high relative height. These scenarios are intended to mimic the near-break conditions of the wave. 5 order solitary wave models are applied to shallow wave scenarios with high relative heights, and 5 order Stokes wave models are applied to short gravity waves with high wave steepness. Stokes waves are further applied in the shallow regime at high wave steepness to examine the wave sensitivity under extreme conditions. Comparisons of spatial and transient discretization methods, implicit versus explicit formulations, and time step size are also conducted. The study concludes that accurate prediction of wave kinematics at nearbreaking condition depends on the choice of an appropriate high order wave model, along with appropriate high order free surface numerics. In particular, the cases studied in this paper illustrate the applicability of 5th order wave models in the shallow and deep-water regimes, and the computational benefit of implicit numerical formulations combined with a second order transient approach to achieve accurate results, even at relatively large time step sizes. The practical numerical limits of wave steepness and relative height for each case are also identified using this approach.
New Oral Direct-Acting Antiviral Agents for Treatment of Chronic Hepatitis-C Infection in Patients with Chronic Kidney Disease Including Dialysis Patients and Kidney Transplant Recipients

As in the general population, the prevalence of HCV in CKD Stage 5D patients varies worldwide, ranging from as low as 1% to as high as over 70%. Overall, the current prevalence of HCV is below 5% in most of Northern Europe, around 10% in most of Southern Europe and the US, between 10 to 50% and up to 70% in many parts of the developing world, including many Asian, Latin American, and North African countries [5-9].