Miracle-dz/UniFAR-FTUs huggingface dataset:
A case with psoriasis vulgaris discontinued due to anaphylactic shock during ixekizumab treatment

A 38-year-old Chinese woman had suffered from psoriasis vulgaris (PV) for more than one year and developed to the disease severity of PASI 12. She visited our hospital requesting treatment by biologics. Clinical examination before beginning treatment with biologics, showed no abnormalities except for slight increase in red blood cells and an indurated cutaneous reaction to tuberculin test, but no sign of clinical tuberculosis. The patient was commenced on treatment with ixekizumab (IXE) 160 mg in divided injections at two sites of the abdomen, but reddish urticarious reactions appeared at the injected sites. No such reactions were reappeared after the 2nd time injections. During 5 times injection the psoriatic eruption almost cleared to PASI 90% (PASI90). However, she had itchy urticarial rashes on her whole body after 7 times self-injection of IXE and she developed anaphylactic shock, although anti-histamine and hydrocortisone were CASE REPORT A Case with Psoriasis Vulgaris Discontinued due to Anaphylactic Shock During Ixekizumab Treatment Fumio Kaneko, Ari Togashi, Tetsuo Nagatani 144 J. of Dermatological Res. 2018 October; 3(1): 144-146 ISSN 2413-8223 Online Submissions: http://www.ghrnet. org/index. /jdr/ doi:10.17554/j.issn. 2413-8223.2018. 03.39 Journal of Dermatological Research injected intravenously. Fortunately, she recovered from the shock after intramuscular injection of adrenalin. After this episode, we examined immunological tests including IgE cap to mouse, hamster and drug-lymphocyte stimulated test by IXE, but no abnormalities detected. In conclusion, we should be aware of the potential to develop anaphylaxis in a patient who develops urticarial reactions at the injection sites of biologics for PV treatment.
Nurses’ Perception of a Tailored Web-Based Intervention for the Self-Management of Pain After Cardiac Surgery

Background Cardiac surgeries rank among the most frequent surgical procedures and present a risk of chronic postsurgical pain (CPSP). A continuum approach is required to prevent the development of CPSP. As a first step, a tailored web-based intervention was developed and successfully tested to tackle pain management during hospitalization. Before proceeding to further development, preliminary acceptability of the intervention including the postdischarge phase must be evaluated. Purpose The purpose of this study was to examine nurses’ perception of a tailored Web-based intervention for pain management in the early recovery phase. The objectives were to evaluate intervention’s acceptability and to identify ways to enhance its acceptability. Methods A parallel mixed methods approach was used to assess the acceptability of the intervention in the early recovery phase (first month after surgery). Results In total, 249 participants completed the online survey and 10 participants were individually interviewed. Overall, the intervention was rated as acceptable. No difference was found in acceptability ratings by demographics. The intervention was rated as appropriate to very much appropriate by 79% of participants. Although nurses seemingly would recommend it to their patients, they did not perceive that their patients would be as highly willing to use it. Interviews highlighted several strengths of the intervention, such as postoperative pain awareness, customization of content, and flexible dosage and schedule. However, the main weakness was related to patient adherence. Opting for a hybrid format and integrating individual preferences could enhance the coaching experience. Conclusion The innovative intervention was judged as acceptable for pain management in the early recovery phase. Considering that the intervention has demonstrated positive effects on the pain experience in the first week after cardiac surgery, it seems logical to explore its potential impact after discharge on the transition to CPSP.
Perfil clínico de los pacientes diagnosticados de Diabetes Mellitus tipo 2 en el Área Sanitaria de Vigo

RESUMEN Fundamentos. La Diabetes Mellitus tipo 2 es una enfermedad cronica que representa un importante problema de salud publica. El objetivo de este estudio fue describir las caracteristicas sociodemograficas, las antropometricas, el control metabolico, la comorbilidad y el riesgo cardiovascular de los pacientes diagnosticados de Diabetes Mellitus tipo 2 del area sanitaria de Vigo. Metodo. Estudio descriptivo observacional retrospectivo. Entre marzo y setiembre de 2016, se realizo entrevista telefonica y auditoria de historia clinica electronica a 195 pacientes ≥ 18 anos del area sanitaria de Vigo diagnosticados de Diabetes Mellitus tipo 2. Se seleccionaron mediante muestreo aleatorio con reposicion. Se evaluo el riesgo cardiovascular mediante el metodo “United Kingdom Prospective Diabetes Study”, el control metabolico segun las recomendaciones de la “American Diabetes Association” 2016, y la comorbilidad mediante el indice de Charlson. Se realizo un analisis descriptivo y bivariante con el paquete estadistico R. Resultados. El control glucemico era adecuado (HbA1c<7,0%) en el 61,03% de los pacientes. El 58,46% tenia una tension arterial <140/90mmHg, 52,82% un colesterol total <185mg/dl y un 66,15% un nivel trigliceridos <150 mg/dl. El 49,74% presentaron una comorbilidad alta (Charlson ≥3 puntos). El riesgo de padecer y/o fallecer de una enfermedad cardiaca era del 37,81%, y del 23,50% el de padecer y/o fallecer de un accidente cerebrovascular en los proximos 10 anos. Conclusiones. La mayoria de los pacientes diabeticos del area sanitaria de Vigo tienen un buen control de su enfermedad pero presentan un alto indice de comorbilidad y un elevado riesgo cardiovascular.
Vestibular findings in patients with schwannoma of the 8th cranial nerve: a survey of nine cases and review of the literature

Abstract Introduction: Some aspects of the natural history of vestibular schwannoma (VS) remain unsettled. A better understanding of the pathophysiology of the disease would improve its diagnostic workup and therapeutic management, as VS often requires surgery, which carries the risk of severe complications. This paper discusses the significance of ultrastructural findings in the vestibular organs removed during surgery. Material and methods: This study examined specimens from vestibular organs removed from patients who underwent VS resection through the translabyrinthine approach. The sample includes 9 patients, seven women and two men, with a mean age of 55 years (range 39–71 years). Results: The sensory epithelium showed a loss of stereocilia, numerous lipofuscin granules and vacuoles in the cytoplasm. The subepithelial myelinated nerve fibres showed signs of demyelination and sheath rearrangement. Some axons had markedly degenerative modifications, with neurofilament aggregation, more numerous mitochondria and vacuolization. As it lost its specialized structures, the epithelial covering of the semicircular canal walls progressively flattened out in the area farthest away from the sensorial area. Conclusions: There were no specific correlations between schwannoma size and instrumental or ultrastructural findings in the vestibular epithelium organs. The morphological features of the non-sensory epithelium suggest that the potassium circulation system is preserved in patients with VS even when they present prominent cochlear and/or vestibular symptoms. VS formation appears to be multifactorial; the vestibular nerve conduction block caused by tumour compression would not necessarily cause irreversible damage to the vestibular receptors at the outset.
Clinical utility of incomplete effort WAIS-R formulas : A longitudinal examination of individuals with traumatic brain injuries

Abstract Arithmetic algorithms have been used to differentiate traumatically brain-injured individuals from simulators and patients with diminished motivation. The sensitivity of three algorithms used to detect incomplete effort was evaluated in traumatically brain-injured patients. The patients had been evaluated two or four times over the course of one year following their injury, allowing for assessment of practice effect on the specificity of the formulas. A method derived by discriminant function analysis (Mittenberg et al., 1995) produced the strongest results, both in terms of overall specificity (ranging from 76% to 93%) and its independence from level of cognitive performance. No practice effect was observed. The use of a method based on a discriminant function appears to minimize false positives in individuals with traumatic brain injuries.
Mountain Gorillas: Subspecific variation in gorilla behavior: the influence of ecological and social factors

Introduction Primates exhibit considerable diversity in their social systems (Smuts et al. , 1987), which is thought to have evolved through an interaction of several factors including ecological variables, social factors, phylogeny, and demographic and life history variables. Attempts to understand how this variation in social organization evolves have focused primarily on (1) ecological variables, particularly predation pressure and the abundance and distribution of food (Alexander, 1974; Wrangham, 1979, 1980, 1987; van Schaik, 1983, 1989, 1996; Sterck et al. , 1997), (2) social factors, primarily sexual selection and the potential risk of infanticide (Wrangham, 1979; Watts, 1989; van Schaik, 1996), and (3) phylogenetic inertia (DiFiore & Rendall, 1994). Gorillas provide a unique opportunity to reevaluate proposed models of ecological and social influences on social organization in African apes. Western lowland and mountain gorillas seem to differ dramatically in their habitats, resource availability, and foraging strategies. To what degree these differences are associated with differences in social organization is an intriguing question. The genus Gorilla occurs in two widely separated forest habitats, one in western central Africa and one in eastern central Africa. Three subspecies of gorillas are generally recognized, western lowland ( G. gorilla gorilla ), eastern lowland ( G. g. graueri ), and mountain gorillas ( G. g. beringei ) (but see Doran & McNeilage, 1998 for reviewof taxonomic debate: Morell, 1994; Ruvolo et al. , 1994; Butynski & Sarmiento, 1995). The three subspecies have not been studied equally. Most of our knowledge of gorilla behavior is based on the pioneering work of Dian Fossey (1974) and subsequent researchers on the well-studied mountain gorillas of Karisoke, Rwanda.
Validation of modified possum scoring system in perforative peritonitis

BACKGROUND AND OBJECTIVES: Perforative peritonitis carries considerable morbidity and mortality. Even if patients reach the hospital at the earliest, still the post operative period is unpredictable most of the times. It therefore becomes necessary for a scoring system that predicts the post-operative period. POSSUM (Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity) helps in predicting the post-operative morbidity and mortality in these patients. POSSUM scores are calculated on the basis of 12 physiological factors and 6 operative factors. In our study we have included two more factors which are specifically important in perforative peritonitis. These two factors are the perforation to operation time, which is the time duration between the occurrence of perforation and operation; and the presence of co-morbidity. The presence of these factors significantly affects the post-operative status of the patients. Through this prospective study we can predict which patients are at a higher risk of death or complication and give appropriate management as necessary. METHODS: In this study, the sample size was 50 patients admitted in Coimbatore Medical College and Hospital, who are diagnosed with peritonitis due to hollow viscus perforation. Data was collected based on factors of POSSUM scoring system. Outcome of the patients was recorded as death / alive; complicated / uncomplicated and statistical analysis was done by comparing the expected and observed outcomes. RESULTS: By applying linear analysis, an observed to expected ratio of 1.005 was obtained for mortality rate and 1.001 for morbidity rate. There was no statistical significant difference between the observed and expected mortality rates (χ2 = 3.54, p = 0.316) and morbidity rates (χ2 = 2.40, p = 0.792). It was found to be comparable to other studies. Two factors were independently studied; perforation to operation time and presence of co-morbidity. A statistical significance was established between these two variables and the outcome. (p<0.05) INTERPRETATION AND CONCLUSION: POSSUM scoring system is a good indicator of post operative outcome in surgeries performed for perforative peritonitis and was applicable in our setup. It may be used in identify high risk patients and give preferential care to these patients for better outcome. Inclusion of factors like perforation to operation time and co-morbid status can improve the scoring system. Hence a modification in the scoring system according to the surgery will more improve the outcome of the patients and better care can be provided to them.
Symptoms Matter: A Symptomatic but Radiographically Elusive Ascending Aortic Dissection

Abstract Symptoms attributable to a thoracic aortic aneurysm (TAA) are a separate indication for prophylactic repair, irrespective of aortic size. We present the case of a 56-year-old female with a history of a thoracic ascending aortic aneurysm (TAAA) and four other heart and arch vessel abnormalities who presented to us with chest pain radiating to her back. Computed Tomography and echocardiography showed no evidence of a dissection and revealed a maximal ascending aortic diameter of 4.2 cm. The patient subsequently underwent root-sparing ascending aortic and hemiarch replacement due to her threatening symptomatology. A focal dissection was discovered intraoperatively, resembling a similar case previously reported by our team.
Comparative Study between Three-Dimensional Transvaginal Ultrasonography and Hysteroscopy in the Diagnosis of Uterine Cavity Abnormalities

Objective: It was aimed at carrying out a comparative study between three dimensional transvaginal ultrasonography and hysteroscopy in the accuracy of detecting intrauterine cavitary lesions. Study design: Three dimensional transvaginal ultrasonography was done followed by hysteroscopy for all cases (number=50). Data obtained were compared and analyzed to estimate the accuracy of 3D transvaginal ultrasound. Results: The comparison with using Hysteroscopy, the sensitivity, specificity, positive predictive value, negative predictive values and total overall accuracy of Three dimensional transvaginal ultrasonography for total abnormal findings were 89.13%, 100%, 100%, 44.44% and 90% respectively. Conclusion: The three dimensional transvaginal ultrasound is a sensitive method to evaluate the endometrial cavity lesions or abnormalities, before resorting to invasive procedures such as diagnostic hysteroscopy. But hysteroscopy allows direct visualization of the uterine cavity so it can detect small intrauterine lesions which could be missed by vaginal ultrasound.
Alergia alimentaria mediada por IgE en la infancia. Estudio descriptivo

Food allergy has increased recently, especially in developed countries, and it is expected to keep on increasing next years. Although it is more common in children than in adults, allergy can appear at any age. There are people named "atopic", which means that it’s easier for them to develop allergy to many foods and environmental substances. Since the cause of this increase is unknown and it seems to be no changes in the genetic characteristic in the last years, some reasons may be related to environmental factors: nutrition and food (transgenic products, processed foods, shortages of fresh food), infections, pollution, an excessive hygiene (it can weak the immune system). A person is said to be allergic to a food when eating it, the body reacts against the proteins of the food itself by means of antibodies or cells and triggering symptoms. Any food can trigger an allergic reaction, but the most frequent are: eggs, cow's milk, nuts, fish, seafood, fruits and vegetables, cereals and legumes, depending on the food that is culturally more consumed. Tolerance to allergens depends on the age at which the allergy occurs and the type of food. Tolerance to milk and eggs is more common when the children are younger. On the other hand, foods that cause the most difficult allergies to disappear are: fish, shellfish, nuts and some fruits.
Induction of Labor and Its Determinant Factors: Retrospective Cross-Sectional Study from a Public Hospital in Ethiopia

Background: Induction of labor is an artificial initiation of labor after the age of viability for the purpose of accomplishing vaginal delivery. It is a common obstetric procedure which is indicated when the benefits to the mother or fetus outweigh, the benefits of continuing the pregnancy. Methods: Hospital based retrospective cross-sectional study design was carried out at Lemlem Karl hospital, Miachew town among 384 mothers chart who gave birth from July 30, 2015 to July 30, 2016. Systematic sampling technique was used to select patient medical cards. Data were entered and coded using Epi Info version 7.0 then analyzed by statistical package for social sciences window version 20. Both bivariate and multivariate logistic regression was used to test the association between determinants and dependent variable with P value <0.05 was considered as statistically significantly. Results: From 384 women who gave birth, 42 (10.9%) labor were initiated by induction. The determinant factors for induction of labor were antenatal follow up at Private clinics [AOR= 3.86, 95% CI (1.29, 11.50)], premature rupture of membrane [AOR=3.57, 95% CI (1.19, 10.76)], pregnancy induced hypertension [AOR=5.033, 95% CI (1.44, 17.62)] and fetal anomaly [AOR=5.68, 95% CI (1.614, 20.12)]. Conclusion: The magnitude of induction of labor in this study was high compare to other previous surveys conducted in Africa. The independent determinants for induction of labor in this study were: Premature rapture of membrane, pregnancy induced hypertension, antenatal visits at private clinics and fetal anomalies. Improve the quality of antenatal care and prepare induction guidelines which works for both governmental and private health care institutions may help to reduce the magnitude of induction of labor and not well convinced reasons for induction.
Role Iron in Diabetes mellitus type 2 of the patients in province Diwaniya

Background: Diabetes mellitus is a common health problem of the world. Iron may be a part of the cause of the disease and its Complications Objectives: This study was designed to determine the relationship between the levels of iron indices and diabetes mellitus type 2. Type 2 Type of the study: Cross –sectional study. Methods: diabetes mellitus is clinical condition characterized by hyperglycemia due to the absolute or relative deficiency of insulin. It is also followed by pathological abnormalities like impaired insulin secretion, peripheral insulin resistance, and excessive hepatic glucose production. Although type 2 diabetes mellitus is a multiple etiological disease, emerging scientific evidences show there is somewhat related to the disease with iron metabolism Results: The study includes thirteen (15 female and 15 male) patient with Diabetes mellitus and (15 male and 15 female ) as the control. In the present study, significantly increased (p < 0.05) At ferretin , iron, transferitin, transferin saturated and significant decrease (p < 0.05) EIBS, TIBC . Conclusions: These results suggest that the role negative of increase iron in development Diabetes mellitus by a number of mechanisms.
Idiopathic Scoliosis

Adolescent idiopathic scoliosis (AIS) is a condition which causes an abnormal curvature of the spine. It is common with between 2 4% of children aged 10 16 being affected. The deformity is actually rotational but it leads to an abnormal lateral curvature of the spine. The curvature should be greater than 10 degrees from the midline for the condition to be diagnosed. The condition has a genetic component and multiple genes are responsible.
Efek Konsumsi Minuman Bubuk Kakao Bebas Lemak Terhadap Sifat Antioksidativ dan Proliferativ Limfosit Manusia

Erniati. The Effect of Fat Free Cocoa Powder Driks Consumption on Antioxidative Activity and Lymphocyte Proliferative of Humans Subject. Di bimbing oleh FRANSISKA R. ZAKARIA, and BAMBANG PONTJO PRIOSOERYANTO. Many researches have shown the potential effects of cocoa for health both in vivo and in vitro. Cocoa can be a rich source of flavonoid antioxidants such as catechin, epicatechin and procyanidin. The aim of this research was to evaluate the effect of Indonesian fat free cocoa powder drink consumption on antioxidative properties and proliferation activities of human lymphocyte. Healthy woman subjects were divided into cocoa group (n = 9) and control group (n = 9). Cocoa powder drinks containing skim milk and sugar was given to the cocoa groups. The control group received only water containing skim milk and sugar. Both cocoa and control group received physical medical check up at the beginning and at the end of the intervention. Their peripheral blood were withdrawn to analyze antioxidant properties and proliferation activities of B and T cells. Antioxidant properties consisted of antiradical by DPPH method, malonaldehyde (MDA), glutathione and oxidation defense. The data of cocoa group showed that there were a significant increased in antiradical and glutathione level and decreased of MDA cell (p 0,056). The result of this research revealed that Indonesian fat free cocoa powder has a potential antioxidant activity which manifest good health functionality. © Hak cipta milik Institut Pertanian Bogor, tahun 2007 Hak cipta dilindungi Dilarang mengutip dan memperbanyak tanpa izin dari Institut Pertanian Bogor, sebagian atau seluruhnya dalam bentuk apapun, baik cetak, fotokopi, mikrofilm, dan sebagainya EFEK KONSUMSI MINUMAN BUBUK KAKAO BEBAS LEMAK TERHADAP SIFAT ANTIOKSIDATIV DAN PROLIFERATIV LIMFOSIT MANUSIA
A phase 1 dose-escalation study of anti-HER3 monoclonal antibody LJM716 in combination with trastuzumab in patients with HER2-overexpressing metastatic breast or gastric cancer.

2519 Background: TheHER2-HER3 heterodimer, a key driver in HER2-positive tumors, is not completely blocked by available therapies. LJM716 is a fully human anti-HER3 monoclonal antibody (mAb) shown to enhance trastuzumab activity in HER2+ preclinical breast and gastric cancer models. Methods: This phase 1, open-label study is currently evaluating LJM716 in combination with trastuzumab in patients (pts) with HER2+ metastatic breast (MBC) or gastric (MGC) cancer who failed previous HER2-directed therapy. The objective for the dose-escalation part of the study was to estimate the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE). Results: As of October 4, 2013, 35 pts (escalation, n = 17; expansion, n = 18) were enrolled (MBC, n = 29; MGC, n = 6) and treated intravenously with LJM716 at dose levels (DLs) 3, 10, 20, or 40 mg/kg once weekly (QW) in combination with trastuzumab 2 mg/kg QW. All pts had prior antineoplastic therapy, including 19 (54%) with ≥ 3 regimens. Common treatment-rela.
Hb A1cin Pregnancy

Introduction and Historical Background of Hb A1c Hb A1c, is a glycated haemoglobin formed by the glycosylation of haemoglobin. The term ‘glycosylated’ was used initially, but it has been pointed out that this term strictly refers to glycosides. Therefore, the Joint Commission on Biochemical Nomenclature has proposed that the term ‘glycation’ is appropriate for any reaction that links a sugar to a protein, or in the particular case of a reaction with haemoglobin, the term ‘glycated haemoglobin’ [1]. Its value represents the glycaemic status of a person over the last two to three months [2].