Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of examiner strength on reliability of hip-strength testing using a handheld dynamometer.

CONTEXT Hip-muscle impairments are associated with a variety of lower-extremity dysfunctions. Accurate assessment in the clinical setting can be challenging due to the strength of hip muscles relative to examiner strength. OBJECTIVE To examine the influence of examiner strength and technique on manual hip-strength testing using a handheld dynamometer. DESIGN Repeated measures. SETTING Research laboratory. PARTICIPANTS 30 active adults (age 24 ± 1.4 y). INTERVENTIONS Three examiners of different strength performed manual muscle tests (MMT) in 2 different positions for hip extension, abduction, and external rotation using a MicroFet handheld dynamometer. Examiner strength was quantified via a 1-repetition-maximum leg press and chest press with a Keiser A420 pneumatic resistance machine. MAIN OUTCOME MEASURES Intrarater reliability (ICC3,1), interrater reliability (ICC2,1), and measured torque values. RESULTS Intrarater reliability for all measurements ranged from . 82 to . 97. Interrater reliability ranged from . 81 to . 98. Main effects for hip extension revealed a significant difference in torque values between examiners and between techniques. For the short-lever hipabduction and seated hip-external-rotation tests, there was a significant difference between examiners. There was no significant difference in measured torque values between examiners with the long-lever hip-abduction or the prone hip-external-rotation tests. CONCLUSIONS MMT of the hip may be performed with high reliability by examiners of different strength. To obtain valid MMT measurements of hip muscles, examiners must consider their own strength and testing techniques employed. The authors recommend a long-lever technique for hip abduction and a prone position for testing hip external rotation to minimize the influence of examiner strength. Both positions appear to provide mechanical advantages to the examiner compared with the alternative techniques. The authors are unable to recommend a preferred hip-extension-testing technique to minimize the influence of examiner strength.
Isolation of plaque-forming, galactose-transducing strains of phage lambda.

Plaque-forming, galactose-transducing lambda strains have been isolated from lysogens in which bacterial genes have been removed from between the galactose operon and the prophage by deletion mutation. -A second class has been isolated starting with a lysogenic strain which carries a deletion of the genes to the right of the galactose operon and part of the prophage. This strain was lysogenized with a second lambda phage to yield a lysogen from which galactose-transducing, plaque-forming phages were obtained. These plaque-forming phages were found to be genetically unstable, due to a duplication of part of the lambda chromosome. The genetic instability of these partial diploid strains is due to homologous genetic recombindation between the two identical copies of the phage DNA comprising the duplication. The galactose operon and the duplication of phage DNA carried by these strains is located between the phage lambda P and Q genes.
Telomerase activation in human fibroblasts during escape from crisis

The immortalization of human diploid fibroblasts requires the circumvention of both the senescence (M1) and crisis (M2) mechanisms of growth control. Cells expressing the SV40 T antigen virtually always bypass senescence, but only rarely escape crisis. The low frequency of this latter event indicates that cellular mutations are necessary to escape crisis. Thirteen subpopulations of T antigen‐expressing human fibroblasts were cultured into crisis. Colonies that appeared to resume growth were assayed for telomerase activity, telomere maintenance, and the immortal phenotype. Our results show that 33 of 35 colonies were telomerase negative and were not immortal. Two colonies were telomerase positive when assayed in the first approximately 15 population doublings after crisis. The first was strongly positive, maintained telomeres at a stable short length, and was later determined to be immortal. The second initially had a weak telomerase signal, grew extremely slowly, and when examined had greatly elongated telomeres consistent with the ALT (alternative lengthening of telomeres) mechanism of telomere maintenance. These cells eventually grew faster and were later determined to be immortal. Additionally, two subpopulations had initially weak and later strong telomerase activity and the cells never entered a defined crisis period. We observed a perfect correlation between telomere maintenance and escape from crisis, supporting the hypothesis that the lack of stable telomeres causes crisis and that the ability to maintain telomeres abrogates crisis. J. Cell. Physiol. 180:46–52, 1999. © 1999 Wiley‐Liss, Inc.
Renal interstitial fibrosis: mechanisms and evaluation

Purpose of reviewTubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IFTA) as the final common pathway. Furthermore, there are multiple ways to assess IFTA. Recent findingsCells involved include tubular epithelial cells, fibroblasts, fibrocytes, myofibroblasts, monocyte/macrophages, and mast cells with complex and still incompletely characterized cell–molecular interactions. Molecular mediators involved are numerous and involve pathways such as transforming growth factor (TGF)-&bgr;, bone morphogenic protein (BMP), platelet-derived growth factor (PDGF), and hepatocyte growth factor (HGF). Recent genomic approaches have shed insight into some of these cellular and molecular pathways. Pathologic evaluation of IFTA is central in assessing the severity of chronic disease; however, there are a variety of methods used to assess IFTA. Most assessment of IFTA relies on pathologist assessment of special stains such as trichrome, Sirius Red, and collagen III immunohistochemistry. Visual pathologist assessment can be prone to intra and interobserver variability, but some methods employ computerized morphometery, without a clear consensus as to the best method. SummaryIFTA results from on orchestration of cell types and molecular pathways. Opinions vary on the optimal qualitative and quantitative assessment of IFTA.
Stochastic comparisons in a price-dependent newsvendor problem with emergency procurement

We consider a newsvendor problem with price-dependent demand and emergency purchase option allowed after the realization of random demand. By stochastic comparisons, we investigate the effects of demand uncertainty on pricing and order quantity decisions as well as expected profit of the newsvendor, under second order stochastic dominance. Our findings include: (i) in general, a less variable demand shock leads to a higher expected profit for both additive and multiplicative demand models; (ii) a less variable demand shock has no effect on price for the additive demand model, while leads to a higher price for the multiplicative demand model. The implications of these findings for pricing and order quantity are discussed.
The Influence of Good University Governance on Human Capital

Objective – This paper examines the influence of Good University Governance ('GUG') on Human Capital ('HC') and Quality, as well as the influence of CUG on HC through the use of Quality . Methodology/Technique – This research uses an explanatory survey design. The data was collected by visiting state and private universities in Indonesia that offer an S1 Accounting Study Program. Twenty cities were covered and responses to 70 questionnaires were processed. The influence of GUG on HC was analysed using a Structural Equation Model (SEM). Findings – The study found that GUG has a significant positive effect on Quality and GUG has a significant positive effect on HC. However, the influence of Quality on HC and the indirect influence of GUG on HC through Quality were negatively significant. Overall, the total influence of GUG on HC was positively significant. Novelty – This study suggests that GUG improves HC and the Quality of services in Indonesian universities. However, improved quality of HC seems to lead to a deterioration in the quality of university services. Further, quality of services fails to mediate the influence of GUG on HC.
Interaction between Shared Displays and Mobile Devices in an Augmented Objects Framework

We are currently seeing a lot of research in the areas of ubiquitous computing involving mobile devices and public shared displays. In this paper, we describe an infrastructure to augment physical objects and an example using this framework to make information available to users, in a specific space, in an automatic and personalized way. The paper presents the ideas that guided the specification of the framework, the requirements for the applications that we developed, the technologies that were employed, and the results so far. The current status of the prototype, using mobile devices and public displays, leads us to think that our framework is generic enough to deal with most interactions between users and real world objects, supported by different types of technologies.
Effects of Zilmax feeding on market dairy cow performance, carcass characteristics, cutability, muscle quality of selected added value beef cuts, and subcutaneous fat quality

Thirty-four market dairy cows (predominately Holstein breeding) were utilized to determine the effects of concentrate feeding and zilpaterol hydrochloride (ZH) on growth performance, carcass characteristics, and carcass yields. Cows, 2 replicates (n = 17 per replicate), were stratified by weight and randomly assigned to 2 treatments: concentrate feed for 42 d (CT) or concentrate feed for 42 d with ZH (7.5 ppm) from d 19-39 followed by a 3 d withdrawal. Over the course of the feeding period, BCS, locomotion score (LS), growth performance, and ultrasonic measurements for ribeye are, 12 rib fat thickness (BF), ribeye ratio (depth:length), and intramuscular fat % were obtained. Cows were harvested at the end of the feeding period and USDA YG and QG data were collected after a 48 h chill (-2°C). Cold side weights (CSW) were recorded and carcasses were fabricated into primals, subprimals, and select added-value cuts. Carcass yields were expressed on a weight and a percentage of CSW basis. Data were analyzed using a one-way ANOVA with replication. Feeding ZH had no effect (P > 0.05) on ADG, G:F, DMI, BCS, LS or BW. For ultrasonic measurements, ZH increased (P < 0.01) REA, but had no effect (P > 0.05) on BF, ribeye ratio, or IMF. Feeding ZH resulted in carcasses with higher (P = 0.01) dressing percentages, larger (P < 0.01) REA, and improved (P = 0.01) YG. No quality traits were affected by ZH supplementation; however ultimate pH for carcasses from ZH-fed cows tended (P = 0.09) to be higher. Weights for the shoulder tender, arm roast, shoulder center, brisket flat, tenderloin, cap off top round, eye round, knuckle, peeled knuckle, and tip center were greater (P < 0.05) for carcasses from ZH-fed cows; and weights of the whole brisket, rib roll, strip loin, top butt, primal round, top round, and tip side tended (P < 0.10) to be higher for carcasses from ZH-fed cows. As a percentage of CSW, shoulder tender, shoulder center, cap-off top round, eye round, and total subprimal percentages were higher (P <
Restriction of P-element insertions at the Notch locus of Drosophila melanogaster

P elements move about the Drosophila melanogaster genome in a nonrandom fashion, preferring some chromosomal targets for insertion over others (J. C. J. Eeken, F. H. Sobels, V. Hyland, and A. P. Schalet, Mutat. Res. 150:261-275, 1985; W. R. Engels, Annu. Rev. Genet. 17:315-344, 1983; M. D. Golubovsky, Y. N. Ivanov, and M. M. Green, Proc. Natl. Acad. Sci. USA 74:2973-2975, 1977; M. J. Simmons and J. K. Lim, Proc. Natl. Acad. Sci. USA 77:6042-6046, 1980). Some of this specificity may be due to recognition of a particular DNA sequence in the target DNA; derivatives of an 8-base-pair consensus sequence are occupied by these transposable elements at many different chromosomal locations (K. O'Hare and G. M. Rubin, Cell 34:25-36, 1983). An additional level of specificity of P-element insertions is described in this paper. Of 14 mutations induced in the complex locus Notch by hybrid dysgenesis, 13 involved P-element insertions at or near the transcription start site of the gene. This clustering was not seen in other transposable element-induced mutations of Notch. DNA sequences homologous to the previously described consensus target for P-element insertion are not preferentially located in this region of the locus. The choice of a chromosomal site for integration appears to be based on more subtle variations in chromosome structure that are probably associated with activation or expression of the target gene.
High-Gain Directional Antenna for WLAN and WiMAX Applications

This letter presents a dual-band slot antenna with high gain for wireless local area network (WLAN) and Worldwide Interoperability for Microwave Access (WiMAX) communication covering the IEEE802.11a/b and IEEE802.16d/e standards. The antenna consists of a microstrip-fed slot with a complimentary stub on a single dielectric medium. A reflecting ground plane is employed to achieve a unidirectional radiation pattern with an average gain of 9.1 dBi. The feed of the antenna is optimized to achieve radiation efficiency above 95% in the WLAN and WiMAX frequency bands. The radiation properties of a prototype antenna were measured in a compact antenna range. Simulated and measured results (impedance bandwidth, gain, and radiation patterns) are presented for the proposed antenna.
Probing the sRNA regulatory landscape of P. aeruginosa: post‐transcriptional control of determinants of pathogenicity and antibiotic susceptibility

During environmental adaptation bacteria use small regulatory RNAs (sRNAs) to repress or activate expression of a large fraction of their proteome. We extended the use of the in vivo RNA proximity ligation method toward probing global sRNA interactions with their targets in Pseudomonas aeruginosa and verified the method with a known regulon controlled by the PrrF1 sRNA. We also identified two sRNAs (Sr0161 and ErsA) that interact with the mRNA encoding the major porin OprD responsible for the uptake of carbapenem antibiotics. These two sRNAs base pair with the 5′ UTR of oprD leading to increase in resistance of the bacteria to meropenem. Additional proximity ligation experiments and enrichment for Sr0161 targets identified the mRNA for the regulator of type III secretion system. Interaction between the exsA mRNA and Sr0161 leads to a block in the synthesis of a component of the T3SS apparatus and an effector. Another sRNA, Sr006, positively regulates, without Hfq, the expression of PagL, an enzyme responsible for deacylation of lipid A, reducing its pro‐inflammatory property and resulting in polymyxin resistance. Therefore, an analysis of global sRNA‐mRNA interactions can lead to discoveries of novel pathways controlling gene expression that are likely integrated into larger regulatory networks.
Chinese Tourist Mobilities and Destination Resilience: Regional Tourism Perspectives

The exponential growth of Chinese inbound tourism to Australia has seen a commensurate increase in the presence of Chinese tourists in regional Australia. This exploratory study raises questions about the extent to which Australian destinations in general, and peripheral or regional areas in particular, are ‘China ready’, and why the vast majority of Chinese tourists tend to stay within capital city/gateway zones with only smaller numbers dispersing into regional Australia. This paper draws from the initial phase of a longitudinal study in the Great Ocean Road (GOR) region of southern Australia that examines Chinese tourists’ perceptions of the region and their associated levels of satisfaction with their experience at the destination. In particular, the dissonance between Chinese tourists’ expectations and their satisfaction levels is a key observation. The managerial implications of managing and marketing regional tourism to Chinese visitors are presented, and it is argued that the necessity to address and meet the demands of the Chinese tourist experience spectrum is pressing. The catch cry for tourist destinations to be ‘China ready’ resonates, and is especially pertinent for destinations beyond gateway cities where the tourism sector capacity tends to be constrained.
Mutual assistance between speech and vision for human-robot interface

This paper presents a user interface for a service robot that can bring the objects asked by the user. Speech-based interface is appropriate for this application, but it alone is not sufficient. The system needs a vision-based interface to recognize gestures as well. Moreover, it needs vision capabilities to obtain the real world information about the objects mentioned in the user's speech. For example, the robot needs to find the target object ordered by speech to carry out the task. This can be considered as a vision assisted speech. However, vision sometimes fails to detect the objects. Moreover, there are objects for which vision cannot be expected to work well. In these cases, the robot tells the current status to the user so that he/she can give advice by speech to the robot. This can be considered as a speech assisted vision through the user. This paper presents how the mutual assistance between speech and vision works and demonstrates promising results through experiments.
Data-Driven Network Management for Dis-Aggregated Softwarized Network System

インターネットは,1990年代に商用化されて以来, 世界規模の自律分散型経路制御,DNSによる階層的な ドメイン名の分散管理,World Wide Web (WWW) などによりコンピュータネットワークの世界的な基盤 となり,90年代後半に常時接続,ADSLや FTTHに よるブロードバンドアクセスにより各家庭での高速な インターネットアクセスが可能となった. 90 年代後 半から普及し始めた携帯電話を用いたインターネット アクセス,無線 LAN技術の普及,第三世代携帯電話 以降の移動体通信網により,モバイル通信は普及し, 高速化が進んできた. このようなトラヒック増加に対 応するため IP 網のバックボーンに光ネットワーク技 術を導入するための研究が 2000年代に活発になされ た [1]~[17]. ムーアの法則は半導体の集積度が 18ヶ月で 2 倍に なると述べている. 半導体の集積度向上による計算
Spectral Approximation of the IMSE Criterion for Optimal Designs in Kernel-Based Interpolation Models

We address the problem of computing IMSE-optimal designs for random field interpolation models. A spectral representation of the IMSE criterion is obtained from the eigendecomposition of the integral operator defined by the covariance kernel of the random field and integration measure considered. The IMSE can then be approximated by spectral truncation and bounds on the error induced by this truncation are given. We show how the IMSE and truncated-IMSE can be easily computed when a quadrature rule is used to approximate the integrated MSE and the design space is restricted to a subset of quadrature points. Numerical experiments are carried out and indicate (i) that retaining a small number of eigenpairs (in regard to the quadrature size) is often sufficient to obtain good approximations of IMSE optimal quadrature-designs when optimizing the truncated criterion and (ii) that optimal quadrature-designs generally give efficient approximations of the true optimal designs for the quadrature approximation of the IMSE.
Vertically Pluggable and Compact 10-Gb/s$\,\times\,$12-Channel Optical Modules With Anisotropic Conductive Film for Over 100-Gb/s Optical Interconnect Systems

We have developed a vertically pluggable and compact 12-channel optical module for intercabinet and intracabinet optical interconnections. Error-free and over 10 Gb/s operation of the optical module with an electrical and optical connector have been demonstrated. The module is designed to be 10 mm in width, 10 mm in length, and 6 mm in thickness so that it can be placed around the central processing units. This compact optical module can be mounted on the inner board area. Further, this module is vertically pluggable in the z-direction, i.e., in a direction that is perpendicular to the board. Because of the vertical pluggability, the optical modules can be repaired much more easily. The optical connector used in the low-height module has 12 fine-drawn graded-index multimode fibers (MMFs). These fibers have a high relative refractive index difference (Delta) and are bent with a 2 mm radius of curvature. The electrical connector consists of an anisotropic conductive film that is sandwiched between an alumina substrate and a printed circuit board with a clamp spring. We have used the alumina substrate to mount the optical device and the driver integrated circuit, because of its high thermal conductivity. In order to reduce cost, we have not used either a microlens or a metal-coated mirror in the optical module. Furthermore, passive alignment between the MMFs and the optical device has been achieved using guide pins assembled in the alumina substrate.
Observation of the unconventional optoelectronic properties of silicon conjugated graphene nanosheets

Graphene has been realized for its significant physico-chemical properties. The extraordinary surface area and high electronical conductivity of graphene makes it a potential candidate in the field of nanoelectronics and sensors. In this study, graphene has been conjugated with silicon and its different physical and chemical properties were evaluated. The total energy of the composite system came out to be −6111.62 eV. Chemical potential of the composite system exhibits ∼ 5.64 eV. DOS calculations for composite of silicon and graphene came out to be ∼ 17 eV−1 for the applied bias voltage of 40 eV, as when compared to higher values of DOS for monolayer silicon and graphene nanosheets. Silicon is widely known to exhibit semiconducting behavior and has already been used in fabricating various CMOS devices. In this present work, we try to study the outcome of the conjugation of graphene nanosheets with silicon nanosheets in different combinations. Understanding the interactions between two semiconducting materials could shed some light in the underlying physical and chemical interaction which would help in devising novel optoelectronic systems.
Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy

This retrospective study aimed to investigate the role that an RNA-binding protein, HuR, plays in the response of high-grade serous ovarian tumors to chemotherapeutics. We immunohistochemically stained sections of 31 surgically-debulked chemo-naïve ovarian tumors for HuR and scored the degree of HuR cytoplasmic staining. We found no correlation between HuR intracellular localization in tumor sections and progression free survival (PFS) of these patients, 29 of whom underwent second-line gemcitabine/platin combination therapy for recurrent disease. Ribonucleoprotein immunoprecipitation (RNP-IP) analysis of ovarian cancer cells in culture showed that cytoplasmic HuR increases deoxycytidine kinase (dCK), a metabolic enzyme that activates gemcitabine. The effects of carboplatin treatment on HuR and WEE1 (a mitotic inhibitor) expression, and on cell cycle kinetics, were also examined. Treatment of ovarian cancer cells with carboplatin results in increased HuR cytoplasmic expression and elevated WEE1 expression, arresting cell cycle G2/M transition. This may explain why HuR cytoplasmic localization in chemo-naïve tumors is not predictive of therapeutic response and PFS following second-line gemcitabine/platin combination therapy. These results suggest treatment of recurrent ovarian tumors with a combination of gemcitabine, carboplatin, and a WEE1 inhibitor may be potentially advantageous as compared to current clinical practices.