Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone marrow edema seen in MRI of osteoarthritic knees is a microfracture

The bladder is the most common site of cancer in the urinary tract and bladder cancer is the fourth and eighth most common cancer in men and women respectively. Bladder cancer can be divided into superficial and muscle invasive cancer. Superficial bladder cancer involves the bladder wall no deeper than the subepithelial tissue. The standard treatment of superficial bladder cancer is a transurethral resection that removes the tumor but it is known that they have a great propensity to recur [1]. Since 1976, urologists have employed intravesical therapies in order to reduce the number and rate of tumor recurrences. One of the best intravesical treatments is BCG immunotherapy. Bacillus Calmette-Gu’erin (BCG) is an attenuated strain of Mycobacterium bovis that enhances the immune response against cancer cells. The antitumor mechanism of intravesical BCG has not been completely understood [2,3]. On the other hand, mutation in p53 gene is the most common genetic defect in this disease. It has been asserted that mutation in p53 gene has high prevalence in human bladder cancer [4]. In a rational approach, introduction of p53 into bladder tumor cells via a recombinant BCG (rBCG) vector can be developed as a new therapeutic strategy against bladder cancer. P53 is the guardian of the genomes. When DNA is damaged, wild-type p53 protein prevents propagation of the cell until the DNA damage is repaired. However, mutations in the p53 gene result in an abnormal and usually dysfunctional protein that accumulates in the nucleus. In majority of tumor cell lines, reintroduction of wild-type p53 is incompatible with the tumorogenic phenotype [4,5]. As a consequence, addition of p53 through various vectors has become a new approach for gene-therapy. So, it seems that a strategy based on both immunotherapeutic effects of BCG and p53 presentation can be used to treat bladder cancer efficiently. Such a combination is achieved by rBCG that secrets p53 protein. This rBCG due to its improved efficacy seems a more powerful therapeutic agent than the current BCG therapy.
Toxoplasmosis Septicaemia: Don't put the Blame on the Cat

A 31-year-old Ecuadorian woman, who arrived in Spain 18 months ago and owned a cat, was admitted in the Emergency Department because of persistent headache, left homonymous hemianopsia and right-leg weakness. Twenty days before, the early symptoms were epigastralgia, fever, non-productive cough and dyspnea. Physical examination: jaundice; blood pressure 105/65 mmHg, heart rate 120 bpm and breathing rate 22 pm. No mucocutaneous candidiasis was present. Abdominal pain in epigastrium and right hypochondrium with positive Murphy’s sign was reported. Glasgow Coma Scale was 15/15 although she felt drowsy, with left inferior homonymous quadrantanopsia, muscular balance 4/5 in right inferior limb and increased reflexes, with negative meningeal signs. The chest X-ray did not show infiltration, although calcificated millimetric basal left nodules were noticed. The electrocardiogram was normal. An abdominal ultrasonography showed multiple hypoechoic periaortical, mesenterical and perileal nodules as large adenopathies with diffuse enlarged circumferencial jejunum intestinal wall. In contrast brain CT (picture A) two enhanced heterogeneous lesions were observed in left basal ganglia and right parietooccipital area. Hemoglobin 12.1 gr/dl, hematocrite 37%, VCM 82.1 fL, white cells 7000/μL (69.8% N, 21.3% L, 8.5% M), platelets 405.000/μL, prothrombin activity 104%, creatinine 0.7 mg/dl, urea 10 mg/dl, glucose 108 mg/dl, sodium 136 mmol/L, kalemia 3.3 mmol/L, AST-GOT 44 UI/L, ALT-GPT 56 UI/L, GGT 36 UI/L, LDH 216 UI/L, amylase 78 UI/L, total bilirrubine 0.3 mg/dl, C Reactive Protein 22.4 mg/L, pH 7.42, pO2 69 mmHg, pCO2 32.1 mmHg, bases gap -3.8 mmol/L, HCO3 20 mmol/L. LCR test: macroscopically cloudy; exit pressure 40 cm H20; glucose LCR 45 mg/dL; proteins 78; white cells 8 / mm3; in Gram, bacterias or cells were not observed. The cryptococcus antigen was negative. Treatment against mycobacteria was performed with four drugs and endovenous steroids, as disseminated tuberculosis was suspected. Lymphomatose or other infectious processes were not ruled out.
Association of snacks consumption with the prevalence of obesity and related metabolic abnormalities among Chinese children

Objective To investigate the association of snacks consumption with the prevalence of obesity and related metabolic abnormalities among children in China.Methods A total of 7 084 children in grade 2nd to 5th,aged 6-13 years were selected to complete the questionnaires from 6 cities(Harbin,Beijing,Jinan,Shanghai,Chongqing,Guangzhou),using multistage random sampling in 2009.Height,weight,waist circumference,blood pressure,fasting glucose level,total cholesterol(TC),high-density lipoprotein(HDL) cholesterol,low-density lipoprotein(LDL) cholesterol and triglycerides(TG) were collected according to the standard procedure.Results The prevalence(OR,95%CI) of obesity among children regularly consuming snacks of the "Eligible to regular consumption","Moderate to consumption" and "Restrained to consumption",was 9.3%(ref),10.2%(1.09,0.88-1.35),11.8%(1.25,1.05-1.50),respectively;And the prevalence of abdominal obesity in different snacks category groups was orderly 13.3%(ref),14.8%(1.14,0.95-1.37),15.8%(1.25,1.07-1.46),respectively;The prevalence(OR,95%CI) of metabolic syndrome in different snacks category groups was 3.4%(ref),3.9%(1.13,0.81-1.58),4.6%(1.34,1.02-1.77),respectively.There was significant difference in the prevalence of obesity,abdominal obesity and hypertriglyceridemia among children in different snacks category groups,after adjustment for age,gender,birth weight,feeding types after birth within 4 months,parents' weight status and educational level,and family income.Conclusion Regular consumption of the restrained snacks can elevate the risk of obesity and related metabolic abnormalities among children.To select snacks such as fresh vegetables and fruits,milk and products,legume and products,as snacks,is healthy for children.It's meaningful to instruct nutrition knowledge to the children.
R of Analysis Model under the Adiabatic Shear Mechanism

A-T model of the modified hydrodynamics, is widely used in metal projectile and target materials, good prediction accuracy for penetration depth in penetration process. But the t R (target defense force) is determined relatively difficult, lack of real physical meaning to widely accepted the t R of calculation model. Based on the role of the existence of adiabatic shear failure mechanism between projectile and target, the t R is endowed with real physical meaning, It can be better reflected the failure mechanism of target plate for influence of the thermal effect and strain rate in penetration. Theoretical model calculation is carried out under the t R of new mechanism, The results are in good agreement with the experimental and simulation results. Keywords—A-T model; penetration; adiabatic shear; failure mechanism
Ewing’s Sarcoma of Maxilla: A Rare Presentation

Ewing’s sarcoma is a rare malignant small cell tumor occurring in the first and second decades of life and usually involving the long bones of the limb. Literature shows that less than 3% of the tumor originates in the maxillofacial region of which 1% occurs in jaw bones with higher predilection for mandible. Mean age of presentation of this tumor in bones of head and neck region is 10.9 years. Surgery is the first line of treatment and considering the aggressive behavior of the tumor multimodality treatment is preferred to reduce recurrence rate. Due to small number of cases affecting the jaws, there are no definite protocols in treatment of Ewing’s sarcoma of maxilla. We are presenting a case of Ewing’s sarcoma of maxilla in a 60 years old patient, as it is involving a rare site and has occurred in an uncommon age group.
PaPilomavírus Humano (HPv) em mulHeres submetidas a r astreamento Para CânCer de CérviCe uterina, b elém - Pará - brasil Human PaPillomavirus (HPv) in Women screened to cervical uterine cancer, Belém - Pará - Brazil

Introduction: human papillomavirus (HPV) is the agent of cervical uterine cancer. Objective: determine the prevalence of genital infection due to HPV and their correlation with results in the oncotic cytology. Methods: in a cross-sectional study, 1021 women, age 30 to 45 years were enrolled and submitted to cervical cancer screening. All patients answered a standard protocol. Samples of the uterine cervix were sent to citopathological analysis and to identification of HPV. Results: prevalence of HPV was 12.4%; in women with normal cervical cytology the prevalence of HPV was 8,7% compared to 43,4% in women with altered cervical cytology (28.9% among women with ASCUS/AGUS; 60.0% among women with LSIL; 90.0% among women with HSIL and 100.0% both in women with invasive carcinoma and in situ adenocarcinoma). Chance of detection of HSIL was 94 times higher in women who had HPV in the uterine cervix. A separate analysis including only the 116 HPV infected women revealed that HPV oncogenic types corresponded to 79.3% of the cases (71.8% in women with negative cervical cytology and 91.1% in women with altered cervical cytology). The frequency of oncogenic HPV types in 116 women infected with HPV was 79.3% [71.8% in women with negative citology and 91.1% in women with abnormalities in the citology exam). The odds to detect abnormalities in the citopatology exam was four times greater in the presence of HPV of high risk. HPV 16 was the most frequent type observed (24.4% of women with abnormal cytology and in 7,0% of those with negative cytology). Multiinfection was detected in 5.7% of women with abnormal cytology and in 1.1% with negative cytology. Conclusion: in this study, HPV infection and abnormal cytological findings in the uterine cervix were frequently observed and there was an association between them.
Deconstructing (And Reconstructing) The Engineering Laboratory

Scientific and engineering accomplishments prior to and during World War II laid the foundation for significant changes in engineering education-- changes that were further accelerated following the successful launching of Sputnik. Courses became oriented more towards theory and analysis and the engineering laboratory changed to support those courses. Experimentation was used to illustrate fundamental and conceptually difficult physical phenomena and to provide “hands-on” experience. In this process of change, the teaching and practice of engineering design principles began to disappear from the curriculum. Issues raised and discussed in this paper support a return to design as the primary purpose for the engineering laboratory. The issues include: the purposes and style of experimentation, the roles of simulation and the computer, pedagogical relationships between the laboratory and the lecture, the role of engineering science in support of design, and intended outcomes for students (graduate school vs. immediate career entry). We provide an example which articulates our goals for an engineering laboratory experience: the gathering of information to support design. Design of Experiments (DOE) techniques are employed to develop a predictive relationship for the dependence of the heat transfer coefficient for a fin as a function of cross-sectional shape, material and convection air speed. The resulting prediction equation is used to design a fin to give off a specified heat rate.
Syndrome factors based on SVM from coronary heart disease treated by prominent TCM doctors

Objective To investigate the general laws of prominent TCM doctors for treating coronary heart disease(CHD). Method A database of diagnosing and treating CHD was set up on the basis of 115 typical medical records from prominent TCM doctors.The syndrome factors and relevant studies were analyzed and conducted by using support vector machine(SVM). Result There were mainly 8 syndrome factors draw,including blood stasis,turbid phlegm,qi deficiency,yang insufficiency,yin deficiency,inner heat,blood deficiency and qi stagnation.The quantitative diagnosis was confirmed and CHD characteristics were explained.The laws of medicate administration for above mentioned 8 syndrome factors were summed up from prominent TCM doctors for treating CHD.Conclusion The study on the syndrome factors reveals the diagnostic connotation and laws of medicate administration from prominent TCM doctors for differentiation and treatment of CHD with Chinese medicine.
Dual Expression of GARP in Immune and Glioma Cells: Yet Another Mechanism of Cancer Immune Escape

Emily Trzeciak1#, Niklas Zimmer1#, Ella Kim2,3, Jonathan Schupp1, Bettina Sprang2,3, Petra Leukel4, Fatemeh Khafaji5, Florian Ringel2, Clemens Sommer4, Jochen Tuettenberg5, Andrea Tuettenberg1* 1Department of Dermatology, University Medical Center Mainz, 55131 Mainz, Germany 2Department of Neurosurgery, University Medical Center Mainz, 55131 Mainz, Germany 3Clinic for Neurosurgery, Laboratory of Experimental Neurooncology, Johannes Gutenberg University, 55131 Mainz, Germa-
New Resources for Undergraduate Power Systems Laboratory

Development of the smart grid and renewable energy generation has been substantially changing the undergraduate education in fundamental power systems. Many new programs in power systems engineering are focused on cross-disciplinary for students not only in traditional electrical engineering, but also in non-electrical engineering, such as computer and information sciences, telecommunication and systems engineering. It is a challenge for these new programs to provide laboratory training of undergraduate students because of the restrictions of physical experimental resources in a power systems laboratory. This paper discusses the new resources for undergraduate power systems laboratories by including the big data generated from smart grids and online information and data of power grid operation.
HARPS Gets New Fibres After 12 Years of Operations

It was already known that circular fibres carry some memory effect of the angular and spatial distribution of the injected light. However, only later it was understood that far-field changes dramatically impact the IP of the spectrograph in presence of optical aberrations ( Perruchot et al., 2010). In the meantime, non-circular fibres had become available and it was demonstrated, by simulation and laboratory tests, that their scrambling efficiency is far superior to that of circular fibres (see Figure 1 and Chazelas et al. [2010], Figures 5 and 10).
Energy Minimization over m-Branched Enumeration for Generalized Linear Subspace Clustering

In this paper, we consider the clustering problem of independent general subspaces. That is, with given data points lay near or on the union of independent low-dimensional linear subspaces, we aim to recover the subspaces and assign the corresponding label to each data point. To settle this problem, we take advantages of both greedy strategy and energy minimization strategy to propose a simple yet effective algorithm based on the assumption that an m-branched (i.e., perfect m-ary) tree which is constructed by collecting m-nearest neighbor points in each node has a high probability of containing the near-exact subspace. Specifically, at first, subspace candidates are enumerated by multiple m-branched trees. Each tree starts with a data point and grows by collecting nearest neighbors in the breadth-first search order. Then, subspace proposals are further selected from the enumeration to initialize the energy minimization algorithm. Eventually, both the proposals and the labeling result are finalized by iterative re-estimation and labeling. Experiments with both synthetic and real-world data show that the proposed method can outperform stateof-the-art methods and is practical in real application. key words: general subspace clustering, energy minimization, multibranch enumeration
A NEW APPROACH TO THE DETECTION AND TRACKING OF MESOSCALE CONVECTIVE SYSTEMS IN THE TROPICS

The study of the life cycle and the characteristics of convective clouds is an important way to understand the tropical hydrological cycle and heat budget. In this context, automatic tracking of convective systems on geostationary images has been the subject of several studies over the past decades. Using infrared imagery, threshold based clustering techniques have been put forth to delineate the cold cloud shield associated with the convective systems and tracked in time using simple overlapping assumptions (e.g., Williams and Houze, 1987; Arnaud et al, 1992, Mathon and Laurent, 2000). These approaches rely upon selecting the minimum size of the object to be tracked, the overlap fraction needed to account for continuity in time and give rise to the so –called splitters and mergers, whereby complex cloudy scenes are segmented into individual mesoscale convective systems. These techniques also rely on a given IR threshold although recent efforts implemented adaptative thresholding version of the cluster detection and overlap approach (Morel and Senesi, 2002). These techniques have been shown very useful to document and study the convection from satellite (Srinivasan and Joshi, 2007). With respect to the detection of clusters associated with mesoscale convective systems, generalized clustering techniques make is possible to somehow elaborate an IR image segmentation with no (or little) dependence on any given threshold. The Detect and Spread (DAS) technique (Boer and Ramanathan, 1997) provides a sound basis for such an enhanced detection of cloud systems. It was successfully tuned to the tropical deep cloud detection using INSAT (Roca and Ramanathan, 2000; Roca et al., 2005) and METEOSAT data (Roca et al., 2002). The aim of the present study is to introduce an improved method for tracking the tropical MCS based on a 3D extension of the above mentioned generalized clustering approach. The methodology is first detailed and then cases studies for the summer 2006 using MSG observations are presented. A systematic comparison with the results of the previous single given threshold and overlap approach is provided to highlight the behaviour of the new method compared to the original one. Season statistics are also shown to complete the new description of organized convection in West Africa obtain using the present approach and a summary of the improvement upon previous approach is finally given.
Restriction enzyme analysis of recombinant plasmids containing streptokinase gene

The recombinant pTargeT.sk10 was digested with different restriction enzyme which showed that HindIII had 2 sites and produced two bands on agarose gel electrophoresis. The BamHI had only one site and therefore the recombinant plasmid was linearised and thus single band was observed. The PstI produced one band. The enzyme PvuI had two sites and thus produced two bands, the enzyme NheI had three sites but two sites were closely located producing one very small fragment and thus only two bands were observed on agarose gel electrophoresis. The enzyme SaII and NotI had one site each and therefore they linearised the recombinant plasmid producing only one band. The recombinant plasmid pSinCMV.sk11 digested with different RE showed that PstI and SpeI produced three bands while NheI, PmeI, NruI, SaII produced two bands each on 1% agarose gel electrophoresis
OEE ENHANCEMENT USING TPM IN LIGHT MACHINE SHOP: A CASE STUDY

The exploration for improving productivity in the current global competitive environment has necessitated for rigorously defined performance measurement system in a manufacturing process. In this paper, Overall equipment effectiveness (OEE), an important measure of Total productive maintenance (TPM), has also been calculated to evaluate performance and productivity of the machine. One way to improve productivity is to utilize equipment as effectively as possible. OEE is a well-known measurement method, which combines availability, performance and quality, for the evaluation of equipment effectiveness in manufacturing industry. A case study on broaching machine from one of manufacturing enterprise in India has been done for OEE calculation. The data has been taken for fifteen working days and a multidiscipline team is formed from different department to eliminate any boundaries between the departments and make the maintenance process more effective. With the proper practice of TPM strategy the three factors quality, availability and performance of OEE increased to 99.03%, 85.03% and 83.13% respectively. A set of techniques has also been suggested to the industry after calculating the OEE to improve their OEE from 58.79% to 70.08%. The results has also been compared with world class level, results of the research demonstrate that although the factors of the OEE evaluated on the broaching machine is not reaching world class level however, with the continuous improvement, performance of the machine may be enhanced up to the level.
Assessment of Stress among Doctors of Dental Medicine

Introduction The workplace can be a source of stress. One of the most stressful professions is the profession of doctor of dental medicine (dentist). Multiple forms of stressors lead to such occupational stress. Objective The research objective was to examine stress levels among dentists in the 25 to 45 year age group. Materials and Methods This cross sectional study included 105 doctors of dental medicine throughout Bosnia and Herzegovina, aged between 25 and 45 years. The research was conducted by means of a confidential on-line survey. All participants signed the informed consent, and voluntarily filled out the survey form. The research used the PERCEIVED STRESS SCALE-PSS 10. The statistical analysis used the IBM Statistics SPSS v.21 statistics packages and Microsoft Excel 2010. Descriptive statistics, X2 test, and T-test were also used. Results Of the total number of respondents, n=105, 66 (63%) of them were female and 39 (37%) male respondents. The mean median value of the score was 23 (Mean = 23.080), as a result of which we can conclude that the respondents in the 25-45 year age population group that participated in this study showed a high level of stress based on the completed questionnaire and the answers received from the respondents. Conclusion The estimated level of stress has been shown to be high in both genders, with no statistically significant difference between genders.
Acinetobacter baumannii is an opportunistic pathogen as an MDRO in ICU I

The genus that we know as Acinetobacter has undergone significant modifications over the past 30 years. Acinetobacter baumannii has become one of the most troublesome pathogens for health care institutions globally. Clinically, especially over the past 15 years, due to its extraordinary ability to increase or become a bacterium that is resistant to antibiotics, making it one of the threatening organisms in the health sector today. A. baumannii strains resistant to all known antibiotics have now been reported, signifying a sentinel event that should be acted on promptly by the international health care community. Acting in synergy with this emerging resistance profile is the uncanny ability of A. baumannii to survive for prolonged periods throughout a hospital environment, thus potentiating its ability for nosocomial spread. However, in the present time, the infection caused can involve the central nervous system, skin and soft tissue, and bone has been monitored as a major problem for certain institutions.3 Interest in Acinetobacter, from both the scientific and public community, has risen sharply over recent years. This level of significant progress in our understanding of interesting about these organisms have attracted more attention since it was last reviewed in this journal in 1996. In this review, we describe the progress of this understanding and also provide a comprehensive assessment of the microbiological, clinical and epidemiological characteristics of A. baumannii, the most clinically relevant species.4