Miracle-dz/UniFAR-FTUs huggingface dataset:
Advanced glycation end products influence oral cancer cell survival via Bcl-xl and Nrf2 regulation in vitro

An irreversible non-enzymatic reaction between carbohydrates and proteins results in the formation of advanced glycation end products (AGEs). AGEs have been demonstrated to be a risk factor of complications in patients with diabetes mellitus (DM). Previous studies have suggested that patients with DM exhibit a higher rate of metastasis of oral cancer and a lower cancer-associated survival rate. The receptor for AGEs (RAGE) has been associated with angiogenesis and an increase in cancer malignancy. Previous studies have suggested that AGE-RAGE regulates cell migration via extracellular signal-regulated kinase (ERK) phosphorylation. Nuclear factor-erythroid 2-related factor 2 (Nrf-2) is associated with the regulation of tumor protein p53 (p53) and the apoptotic response of oral cancer cells. AGEs are associated with oral cancer; however, the mechanism underlying this association remains to be elucidated. The present study hypothesized that AGEs regulate Nrf-2 and downstream pathways through ERK phosphorylation. The results of the current study demonstrated that AGEs inhibit the expression of Nrf-2, p53 and Bcl-2 associated x apoptosis regulator, and increase the expression of apoptosis regulator Bcl-x protein. The effect of AGEs was inhibited through the use of the PD98059. The present study demonstrated that AGEs regulate the downstream pathways Nrf-2 and Bcl-xl via ERK phosphorylation. It is suggested that AGEs regulate the survival of oral cancer cells via Nrf-2 and Bcl-xl through p53 regulation, which explains the poor prognosis of patients with DM who have oral cancer.
Building Blocks for Information Literacy.

1. \ Information Literacy includes a range of strategies and skills that are critical for.educat? rs in the 21 51 century. This article focuses on a module developed to provide 1nstruct1on related to one important set of Information Literacy skills: web searching. Key concepts relevant to basic web searching strategies, web searching tools and the use of pathfinder pages are defined and discussed. Examples of different tools and strategies are pre sented along with practice activities.
Improving Machine Learning Through Oracle Learning

IMPROVING MACHINE LEARNING THROUGH ORACLE LEARNING Joshua E. Menke Department of Computer Science Doctor of Philosophy The following dissertation presents a new paradigm for improving the training of machine learning algorithms, oracle learning. The main idea in oracle learning is that instead of training directly on a set of data, a learning model is trained to approximate a given oracle’s behavior on a set of data. This can be beneficial in situations where it is easier to obtain an oracle than it is to use it at application time. It is shown that oracle learning can be applied to more effectively reduce the size of artificial neural networks, to more efficiently take advantage of domain experts by approximating them, and to adapt a problem more effectively to a machine learning algorithm.
Negotiating safety and acceptability of new contraceptive technologies

Dit artikel beschrijft hoe een mondiaal netwerk van “women’s health advocates”, waarvan de auteur deel uitmaakte, een adviseursrol voor zichzelf in de ontwikkeling van nieuwe contraceptieve technologieen wist te verkrijgen. Het artikel analyseert de wijzen waarop het netwerk kwesties van rechten en veiligheid inkaderde en hoe het netwerk wees op de mogelijkheid van misbruik van twee nieuwe langwerkende contraceptieve technologieen, Norplant en de anti-vruchtbaarheidsvaccinaties. De auteur kijkt terug op haar wisselende rollen in deze controversies. Aanvankelijk, in de Norplant-controversie, was haar voornaamste doel de gezaghebbende medisch-demografische arena die in de ontwikkeling van de technologie was betrokken, te confronteren met de ervaringen van vrouwen, die vanwege machtsverschillen tussen gezondheidswerkers en patienten moeilijk toegang tot gezondheidszorg hadden. Bias en blinde vlekken in de mainstream wetenschappen werden bekritiseerd. In de anti-vruchtbaarheids controversie, begon ze in te zien dat beide partijen heterogeen waren en waren betrokken in een verscheidenheid aan gezichtspunten en belangen. Dit besef leidde tot een nieuwe vorm van betrokkenheid, die van constructieve samenwerking waarin de auteur zocht naar manieren waarop in het proces van ontwikkeling van nieuwe technologie de werkelijke gebruiksters van de technologieen nauwer betrokken konden worden in het vaststellen van de parameters van de technologie, het introductie draaiboek. [script, reproductieve technologie, antropologie van het lichaam, advocacy]
Alceste et WordMapper : l'apport complémentaire de deux logiciels pour analyser un même corpus d'entretiens

This paper demonstrates the complementarity of two types of textual analysis software, Alceste and WordMapper, to analyse a corpus of interviews. Using a top-down hierarchical classification, Alceste made apparent more homogeneous and less numerous groups of discourse than the clusters which result from a bottom-up hierarchical classification, which, on the other hand, made it possible to reveal the inter-articulation of the themes.
Projet Collège+ : validation d’un assistant numérique pour l’inclusion scolaire de collégiens porteurs d’autisme

Le projet propose un outil d'assistance a l'inclusion scolaire permettant d'organiser et de soutenir les activites pedagogiques et communicationnelles d'eleves autistes en milieu ordinaire (i.e., college). Cette assistance s'articule autour d'une tablette numerique. Celle-ci sera utilisable par les eleves et leurs aidants (enseignants, auxiliaires de vie scolaire, educateurs, reeducateurs, etc.) dans leur travail d'accompagnement des eleves autistes. Les tablettes numeriques de nouvelle generation, munies d'un ecran tactile, du reseau sans fil et de camera, representent un support tres prometteur pour une assistance multifonctions de la personne en situation de handicap et a un cout raisonnable. La versatilite de ces tablettes permet une utilisation adaptee aux capacites de l'utilisateur. Dans ce projet, la tablette s'appuiera sur un catalogue ouvert d'applications gratuites, destinees aux elevesavec desordres du spectre de l'autisme : ralenti video, communication augmentee, gestion des routines scolaires, gestion du temps, aide-memoire, enregistrement contextuel, gestion des emotions, scenarios d'interaction sociale, etc.
24 Million and Counting: Reflections on 40 Years of Head Start Research in Support of Children and Families. Washington, DC: Head Start's Eighth National Research Conference Closing Plenary Session

1965. 41 years ago. I suspect many of you were not ready to submit Head Start research grant proposals when the program began! In fact, it’s hard to remember what the world was like 41 years ago, even if you were alive then. I was still a year away from completing my Ph.D. and was narrowly focused on testing Hull-Spence learning theory in an experiment with young children in Cedar Rapids, Iowa. Most of you probably know only second hand about events of the mid-1960s: the “British Invasion” of 1964-1966 that found the Dave Clark 5, the Beatles, and the Rolling Stones on our shores and airwaves. Bob Dylan penned “Like a Rolling Stone” at the beginning of the summer that Head Start began serving 561,000 children in 2,400 communities, and Sergeant Shriver, the first director of the Office of Economic Opportunity (OEO), believed he had found his “direction home. ”
Synthesis Of Multi-Level Circuits Using EXOR-Gates

 There are many methods for the synthesis of logical functions. All these methods can be divided into two classes the first one is Two-Level Logic Synthesis and the second one is Multi-Level Logic Synthesis. The multi-level circuits and their structure are easier for practical realization if there is a large number of variables. In this paper we concentrate on a part of the second class synthesis of multi-level-circuits with EXOR-gates. We present six methods for EXOR-decomposition for both, completely and incompletely specified functions. In detail, we give an iterative algorithm for checking and calculating the EXORgroupability for the incompletely specified functions relating to sets of variables. Using this method, it is possible to fully utilize the characteristics and properties of incompletely specified functions enabling synthesis of very efficent circuits.
MODELING SEQUENCES USING GRAMMARS AND AUTOMATA

An inferred structure can be used to explain a sequence, to predict it, or to state it more concisely. The structure might explain a sequence by providing an insight into the grammar of a natural language or the regularities of a strand of DNA. It might be used to extrapolate a sequence by predicting the actions of a user performing a repetitive task, in order to expedite the process. Finally, since the inferred structure is often smaller than the original sequence, it can might used as a more economical representation of the data.
Learning with Interactive Graphical Representations: assessing the benefits of interactivity through the analysis of learners' video recordings.

Introduction Interactive graphical representations have been used and promoted to facilitate learning (Cheng, 1999). However, not much is known about what kinds of graphical representations and what forms of interactivity are effective (Rogers, 1999). The present research explores how external cognition affects learning (Scaife and Rogers, 1996; Rogers and Scaife, 1997). More specifically it addresses the question of whether providing 3D interactive graphical representations in problems that require the depiction of 3D properties is beneficial for the learning process. In order to address the research question stated above, four Interactive Learning Environments (ILEs) were created with different graphical representations. Each learning environment tackled the same concept in the same manner, except for differences in the diagrams and interactivity. In total, the ILEs were composed of 15 diagrams distributed along six explanatory steps with accompanying text. So, the ILEs are in fact using two different types of representations, graphical and textual, in separate frames. Two 2D systems were built differing in the possibility for learners to manipulate the diagrams' elements. Two 3D systems were also built, again differing in the possibility for learners to manipulate diagrams' elements. The four systems were named 2D, 2DI, 3D and 3DI. The stereographic projection was chosen as the application domain. It is a one-to-one transformation from the surface of the sphere (the surface of a 3D geometric entity), less one point, onto a plane (by definition a 2D geometric entity). In general terms, the concept belongs to the geometry domain, but in the case of this study there is an emphasis on one of its particular applications: the problem of studying symmetry relationships in crystallography. Some of the graphical representations in textbooks explaining the concept are 2D diagrammatic representations that, through the use of pictorial cues are intended to show 3D "objects" (see, for example, Borchardt-Ott, 1995). The issue here is whether these representations are more easily understood when 3D interactive diagrams are employed, considering that students usually have some difficulties learning the concept and manipulating the resulting 2D final representations, the stereograms. Eighty subjects, 42 first year undergraduates studying a geology course and 38 from a mathematics course, were randomly assigned to one of the four ILEs. The experiment comprised three different moments: • Moment 1-Prior to the use of the ILEs, the subjects were tested on their spatial ability through the Paper Folding Test (PFT) (Ekstrom, French and Harman, 1979) and their geometry …
Reinterpreting mobile learning : an activity theoretic analysis of the use of portable devices in higher education

Although there is growing interest in investigating mobile learning, it is not well conceptualised. This thesis investigates the concept of 'mobile learning' by exploring students' routine learning activities mediated by the use of tools and taking place in mUltiple contexts. The exploration does not focus on what and whether students are learning; rather, it focuses on how they use tools to accomplish learning practices. This involves exploring the relationship between context and learning practices. This thesis draws on three case studies that examined the use of portable devices in two Institutions of Higher Education with different contexts: traditional learning and portable technology assisted learning. The methodology used in the studies focused on collecting data that reflects on students' actual utilisation of portable devices and the continuity of that in different contexts (formal and informal) using observations and log files collected from students' portables. In addition, it considered triangulating students' self reports collected through questionnaires and interviews. Moreover, the methodology aimed at capturing the context of learning activities to consider and understand the relationship between context and learning activities. The empirical data was analysed using the concepts of activity theory (Engestrom, 1987) and a theory of mobile learning (Sharples et a1., 2007c). The research led to presenting a conceptualisation of mobile learning using activity theory based on the concept of context-crossing. Context is embodied as the physical as well as the social features of the learning activities which also influences and is influenced by learning activities. The study also found that both new and old portable devices are important for students engaged in mobile learning, however, new portable technologies enable students to practise learning activities and create contexts that students using conventional devices could not do or create.
Analisando a escalabilidade das redes de awareness de um projeto de software distribuído (Analyzing the Scalability of Awareness Networks in a Distributed Software Development project)

Awareness has been a very important concept in the CSCW field. Arguably, this concept is about the fact that an actor needs to monitor the work of his colleagues and, at the same time, inform them about his own work. This facilitates the coordination of collaborative activities. Despite important previous work on this topic, none directly addresses the number of actors that each actor should monitor and, similarly, the number of actors this same actor should inform their activities to. This set of actors is called the 'awareness network'. This paper presents an analysis of the scalability of awareness networks in the context of a large-scale distributed software development project. Our results can be used to inform the design of tools for collaborative software development. Awareness; Jazz; escalabilidade; distribuido (palavras-chave)
Classification Made Simple: An Introduction to Knowledge Organisation and Information Retrieval

Contents: Introduction What is classification? Classification in an information system Faceted classification Practical examples of faceted classification schemes Hierarchical classification Practical examples of hierarchical enumerative classification schemes The use of synthesis in a basically enumerative scheme Synthesis grafted on to an enumerative scheme More about notation More about schedule and citation order Other features of classification schemes The relationship between classification and alphabetical authority lists of indexing terms a " the compilation of thesauri Classification as a search tool Classification and the internet Conclusion Bibliography Index.
Ethnography of an Alternative College Library

This «ethnography» describes multimedia and interdisciplinary research services and programs offered at The Evergreen State College. Among the innovations for integrating library and classroom research instruction which have evolved in the college library's fifteen year history are job exchanges between faculty librarians and teaching faculty, staff taught courses and workshops, and a student centered philosophy of service
WHEN HUMAN EMOTION MEETS TECHNOLOGY. A STUDY OF MACHOVER'S DEATH AND THE POWERS, THE ROBOT OPERA

A vast palette of artistic experiences remains purposely unexplored today by many performers of traditionally oriented opera companies. Ignorance is often the cause of statements such as: absence of melody, of emotions and difficulty in communicating with the audience in the new operatic repertoire. My study offers an assessment: that melody can be identified in the most unusual musical architecture of today's composed opera; and that emotional delivery and communication in the singing art occur still through text, audio-visual, and now, as never before, through technology. In order to demonstrate this I have chosen one single opera, perhaps the newest, but certainly the most innovating of the 21 st century, a masterpiece, that has been in the spotlight since its premiere in 2010 and whose music, libretto and performing production may seem controversial to some of the traditional-oriented performers and audiences. It is Tod Machover's Death and the Powers, the Robot opera. The article also highlights the importance of sustaining innovation in the opera as a need to naturally adapt to the new conduct of life.
Optimal Combination of Information from Multiple Sources.

Abstract : A computer decision aiding system for debiasing and combining information from multiple sources (e.g. human experts, sensors) is proposed. The algorithm is based on six assumptions that apply when the sources are relately knowledgeable with respect to the operator on the variable of interest, and the operator is willing to base his evaluation of their performance on a previously selected (finite) sequence of so called calibration variables. It is also assumed that the operator is interested in maximizing gains, that is, he wishes to act in an optimal or Bayesian manner. An experiment with two human sources of information was conducted to evaluate the performance of the aiding system under a variety of loss functions. On a family of bilinear loss functions, the output of the aid was found to perform better than a naive scheme like simply believing the information the two sources gave. The combination rule was also found to perform better than the output to any individual source. Keywords: Man computer interface. (Author)
RF and Microwave Transistor Oscillator Design

About the Author. Preface. Acknowledgements. 1 Nonlinear circuit design methods. 1.1 Spectral-domain analysis. 1.2 Time-domain analysis. 1.3 Newton-Raphson algorithm. 1.4 Quasilinear method. 1.5 Van der Pol method. 1.6 Computer-aided analysis and design. References. 2 Oscillator operation and design principles. 2.1 Steady-state operation mode. 2.2 Start-up conditions. 2.3 Oscillator configurations and historical aspects. 2.4 Self-bias condition. 2.5 Oscillator analysis using matrix techniques. 2.6 Dual transistor oscillators. 2.7 Transmission-line oscillator. 2.8 Push-push oscillator. 2.9 Triple-push oscillator. 2.10 Oscillator with delay line. References. 3 Stability of self-oscillations. 3.1 Negative-resistance oscillator circuits. 3.2 General single-frequency stability condition. 3.3 Single-resonant circuit oscillators. 3.4 Double-resonant circuit oscillator. 3.5 Stability of multi-resonant circuits. 3.6 Phase plane method. 3.7 Nyquist stability criterion. 3.8 Start-up and stability. References. 4 Optimum design and circuit technique. 4.1 Empirical optimum design approach. 4.2 Analytic optimum design approach. 4.3 Parallel feedback oscillators. 4.4 Series feedback bipolar oscillators. 4.5 Series feedback MESFET oscillators. 4.6 High-efficiency design technique. 4.7 Practical oscillator schematics. References. 5 Noise in oscillators. 5.1 Noise figure. 5.2 Flicker noise. 5.3 Active device noise modelling. 5.4 Oscillator noise spectrum: linear model. 5.5 Oscillator noise spectrum: nonlinear model. 5.6 Loaded quality factor. 5.7 Amplitude-to-phase conversion. 5.8 Oscillator pulling figure. References. 6 Varactor and oscillator frequency tuning. 6.1 Varactor modelling. 6.2 Varactor nonlinearity. 6.3 Frequency modulation. 6.4 Anti-series varactor pair. 6.5 Tuning linearity. 6.6 Reactance compensation technique. 6.7 Practical VCO schematics. References. 7 CMOS voltage-controlled oscillators. 7.1 MOS varactor. 7.2 Phase noise. 7.3 Flicker noise. 7.4 Tank inductor. 7.5 Circuit design concepts and technique. 7.6 Implementation technology issues. 7.7 Practical schematics of CMOS VCOs. References. 8 Wideband voltage-controlled oscillators. 8.1 Main requirements. 8.2 Single-resonant circuits with lumped elements. 8.3 Double-resonant circuit with lumped elements. 8.4 Transmission line circuit realization. 8.5 VCO circuit design aspects. 8.6 Wideband nonlinear design. 8.7 Dual mode varactor tuning. 8.8 Practical RF and microwave wideband VCOs. References. 9 Noise reduction techniques. 9.1 Resonant circuit design technique. 9.2 Low-frequency loading and feedback optimization. 9.3 Filtering technique. 9.4 Noise-shifting technique. 9.5 Impedance noise matching. 9.6 Nonlinear feedback loop noise suppression. References. Index.
Corpus approaches to grammaticalization in English

1. Preface 2. Introduction (by Lindquist, Hans) 3. Three perspectives on grammaticalization: Lexico-grammar, corpora and historical sociolinguistics (by Nevalainen, Terttu) 4. Have to, gotta, must? : Grammaticalisation, variation and specialization in English deontic modality (by Tagliamonte, Sali A.) 5. The semantic path from modality to aspect: be able to in a cross-linguistic perspective (by Aijmer, Karin) 6. The passival and the progressive passive: A case study of layering in the English aspect and voice systems (by Hundt, Marianne) 7. Corpus linguistics and grammaticalisation theory: Statistics, frequencies, and beyond (by Mair, Christian) 8. Grammaticalisation from side to side: On the development of beside(s) (by Rissanen, Matti) 9. Are low-frequency complex prepositions grammaticalized? : On the limits of corpus data - and the importance of intuition (by Hoffmann, Sebastian) 10. Life after degrammaticalisation: Plural be (by Wright, Laura) 11. Subject clitics in English: A case of degrammaticalization? * (by Brinton, Laurel J.) 12. Name index 13. Subject index
Local Reconfiguration of Networks of Processors.

Abstract : This paper studies a local approach to reconfiguration of networks of processors, in which new connections are created only between pairs of processors that have a common neighbor. Algorithms for transforming strings into cycles, trees, arrays, hypercubes, cliques, stars and wheels, and vice versa are presented. The generation of all possible configurations of a given set of processors is also discussed. (Author)
MRSVP: A Reservation Protocol for an Integrated Services Packet Network with Mobile Hosts

This paper describes a reservation protocol to provide real-time services to mobile users in an Integrated Services Packet Network. Mobility of hosts has signi(cid:12)cant impact on the quality of service provided to a real-time application. The currently proposed network system architecture and mechanisms to provide real-time services to (cid:12)xed hosts are inadequate to accommodate the mobile hosts which can frequently change their point of attachments to the (cid:12)xed network. Mobile hosts may experience wide variations of quality of service due to mobility. Therefore, a new real-time service architecture is necessary to accommodate mobile hosts which can tolerate variations in QoS and those which want mobility independent service guarantees in the same network. To obtain mobility independent service guarantees, a mobile host needs to make resource reservations at all locations it may visit during the lifetime of the connection. The currently proposed reservation protocol in the Internet, RSVP, is not adequate to make such reservations for mobile hosts. In this paper, we describe a new reservation protocol, MRSVP, for supporting Integrated Services in mobile networks.