Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanism of Action of Gq to Inhibit Gβγ Modulation of CaV2.2 Calcium Channels: Probed by the Use of Receptor-Gα Tandems

The stable interaction of a G-protein coupled receptor and a particular partner G-protein was made possible by creating tandems between the α2A adrenergic receptor (α2A-R) and pertussis toxin-resistant mutants of different Gα subunits of heterotrimeric G-proteins. Both α2A-R-Gαoand α2A-R-Gαi proved able to reconstitute agonist-induced voltage-dependent inhibition of N-type calcium channels (CaV2.2) similar to the wild-type α2A-R when expressed in COS-7 cells. The interaction of Gq with the Gi/o signaling pathways was studied by expressing either Gαq or a chimeric construct based on Gαqcontaining the last five amino acids of Gαz, which is activated by α2A-R. It was found that Gαqz5activated by the wild-type α2A-R inhibited CaV2.2 currents in a voltage-independent fashion. Furthermore, Gαqz5 counteracted the voltage-dependent inhibition resulting from α2A-R-Gαoactivation. We subsequently investigated the basis for the behavior of Gαqz5. Our evidence suggests that this occurs as a result of a downstream effect of activation of Gαqz5 because it was blocked by C-terminal construct of phospholipase Cβ1. Furthermore it is likely to occur in part via protein kinase C (PKC) activation, because the PKC activator phorbol dibutyrate mimicked the effects of Gαqz5 in α2A-R-Gαo-transfected cells. Conversely, cells expressing both α2A-R-Gαo and Gαqz5 exhibited a partial restoration of voltage-dependent inhibition in the presence of the PKC inhibitor bisindolylmaleimide I (GF 109203X). The potential sites of phosphorylation are discussed.
LHC crab-cavity aspects and strategy

The 3rd LHC Crab Cavity workshop (LHC-CC09) took place at CERN in October 2009. It reviewed the current status and identified a clear strategy towards a future crab-cavity implementation. Following the success of crab cavities in KEK-B and the strong potential for luminosity gain and leveling, CERN will pursue crab crossing for the LHC upgrade. We present a summary and outcome of the variousworkshop sessions which have led to the LHC crab-cavity strategy, covering topics like layout, cavity design, integration, machine protection, and a potential validation test in the SPS.
Drivers of Market Participation Decisions among Small-scale Farmers in Yam Growing Areas of Nigeria and Ghana

Participation in agricultural markets could be the main weapon against hunger to lift millions of poor farmers out of poverty traps. Unfortunately, most of the potential beneficiaries are constrained by several factors in their quest to participate in the yam market. This study, thus, clarified the underpinning drivers of market participation among small-scale farmers in yam belt of West Africa. Using a multistage random sample of 1400 households, the study tests the hypothesis that factors affecting farmers’ decision to participate are not necessarily the same as those affecting the extent of participation. Non-price constraints played a significant role in determining decisions on market participation. Policies that reduce transactions costs and induce farmers to commercialize could be critical alternatives to policies based on price to promote a marketed surplus and the commercialization of agriculture by yam farmers and thereby alleviate poverty.
Quality characteristics of bread produced from composite flours of wheat, plantain and soybeans

The use of soy flour (SF) and plantain flour (PF) substitution in wheat flour (WF), from 0 to 15% each, for the production of bread was investigated. The proximate analysis, sensory evaluation and aerobic plate count (APC) of the bread samples were determined. The crude protein, crude fiber, ether extract and ash contents of the soy supplemented breads (SSBs) increased with progressive increase in the proportion of soy flour, with the 15% SSB having highest values of 8.39, 0.14, 2.46 and 1.17%, respectively, while lowest values were recorded for the whole wheat bread (WWB). The carbohydrate content was observed to decrease with corresponding increase in the percentage of soy flour in SSBs. The sensory evaluation shows that no significant differences were observed between the WWB and the 5% SSB in the sensory attributes of aroma, internal texture, taste and general acceptability (p<0.05), but differences were significant in crust, shape and appearance. The crude protein of the plantain supplemented breads (PSBs) and the WWB ranges between 6.88 and 7.01%, with the WWB recording the highest value. The ash content increased with progressive increase in the proportion of the PF, the highest value (0.95%) was recorded for the 15% PSB. There were no significant differences (p<0.05) between the WWB and the PSBs up to 10% PF substitution in all the sensory attributes tested; crust, taste, aroma, shape, internal texture, appearance and general acceptability. Hence the PSBs had comparable sensory and nutritional qualities to the WWB, while the SSBs had higher proteins contents than the latter. However the WWB had highest Hedonic mean scores in all the sensory attributes tested.
AnCora-Verb: Two Large-scale Verbal Lexicons for Catalan and Spanish

In this paper, AnCora-Verb is presented: two large-scale verbal lexicons used for the semantic annotation with arguments, thematic roles and semantic class of AnCora corpora (AnCora-Cat for Catalan and AnCora-Esp for Spanish). Each corpus contains 500,000 words with a multilayer annotation in different linguistic fields-from morphology to pragmatics. AnCora-Verb lexicons focuses on syntactic functions, arguments and thematic roles of each verbal predicate taking into account the verbal semantic class and those alternations in diathesis where the predicate can participate. This paper concentrates on the definition and characterization of verb classes and the criteria followed in the assignment of a verb to a specific class.
The Impact of Location-Based Service Factors on Usage Intentions for Technology Acceptance: The Moderating Effect of Innovativeness

This study presents features of location-based services (LBS) that influence usage intentions in users and the moderating effects of innovativeness for LBS in sustainable mobile-related industries. As LBS attributes, this study identifies location awareness, reputation, trust, and entertainment. This study model is developed based on technology acceptance behavior (TAB) and is applied to LBS users to identify LBS usage intention factors and TAB perspectives. Research measures are identified and examined on 220 LBS users. The study results are discussed to explore significant factors affecting LBS technology acceptance intentions. The results show that LBS users are more likely to adopt LBS with features of location awareness, reputation, trust, and entertainment. In addition, user attitudes toward LBS are found to play a significant positive role, as are user usage intentions. The moderating effects of personal innovativeness on the relationship between reputation, trust, and entertainment and user attitudes toward LBS are found to be insignificant. The implications for theory and practices are discussed.
Age Changes and Sex Differences in Somatotypes among Jats of Delhi

Abstract Somatotype studies have both pedagogic and pragmatic merits. With a view to delineate age changes and sex differences in anthropometric somatotype and its three components, viz., endomorphy, mesomorphy and ectomporphy among Jats of Delhi in the age range of 10 to 18 years, data were collected on Jat boys (308) and girls (272). Jat boys and girls have primarily meso-ectomorphic, balanced ectomorphic and central type of physique. Generally Jat girls are more endomorphic and less ectomorphic than Jat boys. With advancement in age, Jat boys tend to become balanced ectomor phic from meso-ectomorphic, whereas Jat girls have a tendency to become central type from balanced ectomorphic type of physique.
Interaction of the Upwelling Plume with the Phase and Chemical Boundaries (2) -Effects of the Pressure-Dependent Viscosity-

Numerical simulations have been performed to investigate interaction of upwelling plumes with the 670 km discontinuity. Effects of pressure-dependent rheology on this interaction are evaluated in this study because pressure-dependence of the viscosity affects the amount of the buoyancy of the plume. The 670 km discontinuity is taken as phase and/or chemical boundaries. The condition for the plume to penetrate into the upper mantle is examined by varying the value of the Clapeyron slope and the compositional density difference. The plume can penetrate and reach the bottom of the lithosphere when the Clapeyron slope is gentler than − 5 MPa/K for the pure phase boundary, and when the compositional density difference is smaller than 1.0% for the pure chemical boundary
Explore Locally, Excel Digitally: A Participatory Learning After-school Program for Enriching Citizenship On- and Offline

This paper discusses the design and implementation of a participatory culture pedagogy in the context of a pilot after-school program at Los Angeles Unified School District’s Robert F. Kennedy Community Schools. Ethnographic fieldnotes, instructor and student reflections, photographs, video recordings, and student work illustrate the program’s culture of participatory learning, characterized by motivation and engagement, creativity, relevance, co-learning, and ecological learning. ELED also supported participants’ acquisition of digital literacy skills, new media literacies, and social and emotional learning competencies. This experience suggests that relationship building is integral and foundational to establishing citizenship, both online and offline.
Breeding ecology of Scinax trapicheiroi (Anura, Hylidae) at a creek in the Atlantic Rainforest of Ilha Grande, southeastern Brazil

We analyzed the breeding biology in a population of the hylid Scinax trapicheiroi and evaluated how some environmental and structural factors affect the temporal and spatial distribution of the clutches. Fieldwork was carried out at a small stream running inside the Atlantic Rainforest at Ilha Grande, an island in Rio de Janeiro State, southeastern Brazil, from October 2000 to September 2001. Breeding occurred all year round, but the presence of females and clutches was affected by rain from the previous days. Clutches had an aggregate distribution, because they were mainly laid on lentic waters (with slow water flow). Rain affected the availability, stability and size of ponds. The high numbers of eggs per clutch, and the fast development of eggs and larvae are influenced by an unpredictable environment.
Simplified Approximate Expressions for the Boundary Layer Flow in Cylindrical Sections in Plankton Nets and Trawls

Trawls and plankton nets are basically made up of conical and cylindrical net sections. In conical sections the flow will pass through the inclined net wall with a noticeable angle of attack, and then the flow, filtration and drag can be suitably modelled e.g. by a pressure drop approach [1]. In cylindrical and other non-tapered net sections, such as foreparts and extension pieces in trawls and plankton nets, the flow is directed along the net wall and is best considered in terms of a boundary layer. Boundary layer theory and turbulence models can be used to describe such flow, but this requires extensive numerical modelling and computational effort. Simplified approximate formulas providing a qualitative description of the flow with some quantitative accuracy are therefore also useful. This work presents simplified parametric expressions for boundary layer flow in cylindrical net sections, including the boundary layer thickness and growth rate along the net, the filtration velocity out of the net wall, the decrease in mass flux through the net due to the growing boundary layer, and the effect of twine thickness, flow (towing) velocity and the dimensions of the net. These expressions may be useful for assessing the existence and extension of a boundary layer, for appropriate scaling of boundary layer effects in model tests, for proper placement of velocity measurement probes, for assessing the influence on filtration and clogging of plankton net sections, and more.
Information needs and study behaviour of non- traditional students with particular reference to university libraries in Kenya

The purpose of the study was to investigate the information needs and study behaviour of nontraditional university students, university libraries’ role in information provision, how it impacts on the academic development of the students, challenges they face and make recommendations on how the university libraries can improve the situation. The non-traditional students face many challenges that include lack of adequate time to study, communication breakdowns, inadequate information resources, lack of support from their employers or sponsors, family commitments and shortage of trained library personnel. Meeting the needs of non-traditional students by the university libraries is essential to the social role of the library. These can only be achieved if university libraries adequately revamp and organize library and information services in recognition of their growing user needs, which include access of information in the comfort of their locations; whenever and wherever they are. Data was collected from the existing sources which included both print and electronic media as well as utilizing the author’s professional experience. The study recommended that proper planning for non-traditional students need to be done with the urgency it deserves in line with their growing demand for library and information services across universities. The planning should be done in a way that the traditional students should not have undue advantage over the non-traditional ones.
2.5-Year-Olds’ Retention and Generalization of Novel Words across Short and Long Delays

ABSTRACT Two experiments investigated two-year-olds’ retention and generalization of novel words across short and long time delays. Specifically, retention of newly learned words and generalization to novel exemplars or novel contexts were tested 1 min or 1 week after learning. Experiment 1 revealed successful retention as well as successful generalization to both new exemplars and new contexts after a one-minute delay, with no statistical differences between retention and generalization performance for either generalization type. Toddlers tested after a week delay (Experiment 2) showed successful retention and generalization as well, but while context generalization was statistically equivalent to retention accuracy, exemplar generalization was significantly lower than retention accuracy. The overall success in both retention and generalization suggests that toddlers’ newly learned words are robust and flexible. However, the lower exemplar generalization performance compared to retention after a weeklong delay suggests that novel words may become less flexible across exemplar characteristics over time.
ON THE OCCURRENCE OF MYOTIS ALCATHOE VON HELVERSEN AND HELLER, 2001 IN AUSTRIA

In 2006, two males and one female of Myotis alcathoe were captured by mistnets at two localities in southern Burgenland, Austria. For two individuals the prelimi- nary specific identification based on external measurements was confirmed by sequencing parts of the mitochondrial ND1 gene. Across the sequenced region, the two analysed bats share a 100% identical haplotype that corresponds to the haplotype found in Hungarian bats identified as M. alcathoe, and was found also in Spanish, French and Slovakian samples. The three animals from Burgenland constitute the first records of this species in Austria. Age related differences in pelage and membrane coloration and measurements of M. al- cathoe are described. A comparison of skull length measurements between M. alcathoe and Myotis mystacinus seems to indicate that the interspecific difference in external dimensions is not reflected in skull dimensions. The Austrian localities of M. alcathoe belong to the Pannonian part of the range, as do findings from Slovakia and Hungary.
Fluctuating levels of reprogramming factor expression in cultured human undifferentiated keratinocytes

Although human undifferentiated keratinocytes (HUKs) can be reprogrammed to become induced pluripotent stem cells (iPSCs) with high efficiency and rapid kinetics by transducing reprogramming factors (RFs), the endogenous expression of reprogramming factors in cultured HUKs is not clear at different stages. In this study, keratinocytes were isolated from foreskin of adult subject (18 years old) and cultured on collagen type IV-coated culture dishes in a low-calcium, serum-free medium (Epilife, Invitrogen). In order to clarify the expression patterns of RFs and other stem cell markers in cultured human keratinocytes, total RNA was extracted using Trizol reagent, and polymerase chain reaction (PCR) was performed using established GenBank sequences to design primers. The subsequent PCR analysis was carried out by agarose gel electrophoresis. The expression levels of RFs and other stem cell markers in human HUKs clearly fluctuated during culturing, which supports the hypothesis that HUKs might be reprogrammed into a pluripotent state when the maximum levels of RFs expression are maintained by appropriate culture conditions.
Developing Key Performance Indicators for the Customer Experience Lab

Author Title Number of Pages Date Niina Aho Developing Key Performance Indicators for the Customer Experience Lab 68 pages + 3 appendices 11 May 2017 Degree Master of Engineering Degree Programme Industrial Management Instructors Dr. Juha Haimala, Principal Lecturer, Head of Department of Industrial Management Sonja Holappa, M.A., Senior Lecturer Zinaida Grabovskaia, PhL, Senior Lecturer This thesis focuses on developing Key performance indicators for the case company Customer experience lab. At the same time, this study defines the process to measure the success of the Customer experience lab. The business were the case company is operating is changing from product-orientated business to service-orientated business, and there is a need to increase customer satisfaction to be able to stand out from the competition. The study was conducted by exploring existing case company documentation including information gathering from the global and local key stakeholders through workshops, interviews and discussions. This study uses case study methodology and qualitative data as a source for the data collection. The business challenge of this study was to measure the success of the Customer experience lab in terms of the case company employees’ behavioral change, the case company employees’ mindset change, and the case company customer satisfaction. Main findings from the Current state analysis was the gap in the existing processes of the Customer experience lab and expected outcomes of the management team. Processes that already existed were not addressed by this study, but the process that did not exist were the outcome of this study together with the Key performance indicators. The result of this study will be used to measure the success of the Customer experience lab in the case company. Future will show whether the results will be in that level that this way of working is valuable for the case company.
Memoirs of the National Museum of Victoria

excavations to establish the general relationship of artifacts to deposits in this terrace. Since I had an ample labour force from students of the Department of Anthropology at the University of Sydney I decided to concentrate my efforts on a limited volume of deposit. The intensive examination of this intractable deposit means that we can make a confident statement about a total industry from the Keilor terrace. Small objects in the sample excavated should be at their true proportionate frequencies compared with the larger, more readily recovered, objects. Mulvaney's nore extensive exploration is thus complemented by this intensive
STUDY OF INTRACRANIAL ABSCESS IN GANDHI MEDICAL COLLEGE BHOPAL FROM JUNE 2010 TO MAY 2014

A prospective and retrospective study was conducted in Hamidia hospital and Gandhi medical college Bhopal from year June 2010 to May 2014. Study included patients having intracranial abscesses. The objective was to know the incidence and prevalence, clinical features and management as well as outcome. Radiological and microbiological investigations were done. Procedures performed were lumbar puncture and intracranial abscess drainage by aspiration or craniotomy in few patients. There were total 33 patients in five years out of which 17 patients were operated and 16 were treated conservatively. Most common complication was residual abscess, meningitis and persistent hemiplegic. KEYWORD: Intracranial abscess, Conservative antibiotic therapy, Surgical craniotomy. INTRODUCTION: Intracranial abscesses are uncommon, serious, life threatening infections. Similar to the abscess in other sites, the pyogenic brain abscess is a collection of pus presenting as a mass like lesion. The pyogenic brain abscess can present with fatal illness. (1) Brain abscess is still related to high rates of neurological impairments and death. Intracranial abscesses include brain abscess, subdural empyema and intracranial epidural abscess and are classified according to the anatomical location or the etiological agent. The term brain abscess is used in this article to represent all types of intracranial abscesses. A brain abscess is a focal, intra cerebral infection that begins as a localized area of cerebritis and develops into a collection of pus surrounded by a well – vascularized capsule. Subdural empyema is focal collection of pus located between the,(2,3,4) duramater and the arachnoid mater, while an intracranial epidural abscess is accumulation of pus between the skull and dura mater. Intracranial abscesses can originate from infection of contiguous structures (e.g., otitis media, dental infection, mastoiditis, sinusitis) secondary to hematogenous spread from a remote site (Especially in patients with cyanotic congenital heart disease), after skull trauma or surgery, and rarely, following meningitis. In at least 15 % of cases, no source can be identified. (5,6) Most of the reports from India are from latter half of the 20th century. These reports mainly deal with the bacteriology of brain abscesses. Aim of this Study is to analyze the current epidemiological, bacteriological, pathological and radiological picture of brain abscess. We shall also analyze various treatment options. The data will then be compared with the available literature. In recent years, the complex array of etiologic agents that cause brain abscess has become better understood. AIMS AND OBJECTIVES: 1. To Study Incidence and Prevalence of Brain Abscess. 2. To Study Causes and Portal of Entry of Brain Abscess. 3. To Study Clinical Feature and Management Of Brain Abscess. 4. To Study Outcome of Brain abscess. DOI: 10.14260/jemds/2015/2001