Miracle-dz/UniFAR-FTUs huggingface dataset:
Floating Drug Delivery Approaches for Prolonged Gastric Retention

Floating drug delivery systems are promising dosage forms to get prolonged drug release in gastric environment. These are hydro dynamically balanced systems which remains floatable in stomach contents. Most of the drugs are orally less efficient when they are present in intestinal and colonic environment. Floating systems offer the benefits for such type of drugs. The present review briefly explains the advantages and disadvantages of floating systems. This article mainly explains about different approaches for gastric retention and types of floating drug delivery systems. This review exclusively gives the different approaches for floating of dosage forms in gastric contents.
Challenges in Heritage Documentation with Terrestrial Laser Scanning

The paper discusses data acquisition and processing of laser scan point clouds based on experiences gained while documenting heritage sites for the African Cultural Heritage Sites and Landscapes database. More than 6000 individual scans of buildings, rock shelters and landscapes have been recorded and have shown the advantages of laser scanning over other methods, but also exposed challenges which need to be addressed to develop the full potential of laser scanning. Experiences with field work, scan registration, hole-filling, data cleaning, modelling and texturing as well as display options are reported and briefly discussed. A sometimes unrealistic view of the potential of terrestrial laser scanning as the answer to all spatial documentation is emerging among potential users of laser scan data without technical experience of 3D data acquisition and the complexity of the processing. An attempt will be made to correct some of the unrealistic expectations and to make the user community of laser scan data aware of the complexity and limitations of present data processing methods and technologies while not taking away from the unquestionable value and relevance of laser scanning for heritage documentation. Keyword: Terrestrial Laser Scanning, Cultural Heritage, Digital Preservation, Surface Reconstruction, Texturing, Visualization, Registration, Field Procedures
N ov 2 01 4 Twisted spectral triple for the Standard Model and and spontaneous breaking of the Grand Symmetry

Grand symmetry models in noncommutative geometry have been introduced to explain how to generate minimally (i.e. without adding new fermions) an extra scalar field beyond the standard model, which both stabilizes the electroweak vacuum and makes the computation of the mass of the Higgs compatible with its experimental value. In this paper, we use ConnesMoscovici twisted spectral triples to cure a technical problem of the grand symmetry, that is the appearance together with the extra scalar field of unbounded vectorial terms. The twist makes these terms bounded, and also permits to understand the breaking to the standard model as a dynamical process induced by the spectral action, as conjectured in [20]. This is a spontaneous breaking from a pre-geometric Pati-Salam model to the almost-commutative geometry of the standard model, with two Higgs-like fields: scalar and vector.
Reduce & Attribute: Two-Step Authorship Attribution for Large-Scale Problems

Authorship attribution is an active research area which has been prevalent for many decades. Nevertheless, the majority of approaches consider problem sizes of a few candidate authors only, making them difficult to apply to recent scenarios incorporating thousands of authors emerging due to the manifold means to digitally share text. In this study, we focus on such large-scale problems and propose to effectively reduce the number of candidate authors before applying common attribution techniques. By utilizing document embeddings, we show on a novel, comprehensive dataset collection that the set of candidate authors can be reduced with high accuracy. Moreover, we show that common authorship attribution methods substantially benefit from a preliminary reduction if thousands of authors are involved.
Fast image segmentation by Watershed Transform on Graphical Hardware

The watershed transform is widely used for image segmentation on computer vision applications. However, sequential watershed algorithms are not suitable for fast applications, once they are one demanding part of several tasks. This paper proposes two parallel algorithms for the watershed transform focused on fast image segmentation using off-the-shelf GPUs. In this sense, these algorithms aims for a speedup by mixing several techniques of the fastest procedures on both sequential and parallel ﬁelds. Both algorithms has four major steps, the parallel version processed on SIMD, and the hybrid version mixing parallel and sequential approaches. The experimental results obtained show that the hybrid version is faster, taking advantage of the most appropriate hardware for each task.
Metabolic Alteration and Amyotrophic Lateral Sclerosis Outcome: A Systematic Review

Background: The development of strategies that could not only efficiently detect the onset of Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disorder with no cure but also predict its development and evaluate therapeutic intervention would be of great value. In this respect, the metabolic status of ALS patients has called attention. Hence, this study aimed to investigate the potential correlation between changes in ALS's metabolic parameters with the disease outcome in a systematic review. Methods: The manuscripts were manually searched within different databases (PubMed, Web of Science and Cochrane). The inclusion criteria were original articles and reviews about individuals with ALS and its survival, disease prognosis and metabolism (weight, cholesterol, hypertension, BMI, and glycaemia). The authors also established three different exclusion criteria: studies including ALS and other degenerative disorders, works including animal models and published before the year 2000. Results: In total, 29 papers were selected. From all manuscripts, only 82.8% ensured the participation of sALS patients. Also, 27.6% of selected studies described the presence of a genetic mutation. Regarding ALS prognosis, patient's age, the age of ALS onset, ALS duration and survival, <50% of the papers addressed these issues. Specifically, regarding metabolism, 65.5% of articles mentioned BMI, 20.7% mentioned any data concerning hypertension, 6.89% cardiovascular risk, 10.3% obesity, 13.78% diabetes and 10.3% glycaemia. Concerning lipid metabolism, more results were gathered, but still, they did not suffice to establish a correlation with ALS development. Conclusions: Altogether, the authors concluded that available information is not enough to establish a link between ALS and metabolism. In reality, less than half of the manuscripts evaluated show an association between both factors. Nonetheless, it is worth mentioning that metabolism does influence ALS, but not in a unique manner. There is a debate about patients' hypo- and hypermetabolism. Thus, to provide a reliable record, a public policy in which all research and clinical centers might assess the parameters discussed herein is suggested. Accordingly, this systematic review attempts to provide a comprehensible database to facilitate multicentered collaboration, validation, and clinical translation.
Faster decoding of rank metric convolutional codes

A new construction of maximum rank distance systematic rank metric convolutional codes is presented, which permits to reduce the computational complexity of the decoding procedure, i.e., of the underlying Viterbi algorithm. This result is achieved by lowering the number of branch metrics to be calculated and by setting to the highest value the metric of the remaining edges in the trellis.
Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma

Animal studies suggest that the time of day is a determinant of the immunological response to both injury and infection. We hypothesized that due to this diurnal variation, time of injury could affect the systemic inflammatory response and outcomes post-trauma and tested this hypothesis by examining the dynamics of circulating inflammatory mediators in blunt trauma patients injured during daytime vs. nighttime. From a cohort of 472 blunt trauma survivors, two stringently matched sub-cohorts of moderately/severely injured patients [injury severity score (ISS) >20] were identified. Fifteen propensity-matched, daytime-inured (“mDay”) patients (age 43.6 ± 5.2, M/F 11/4, ISS 22.9 ± 0.7) presented during the shortest local annual period (8:00 am−5:00 pm), and 15 propensity-matched “mNight” patients (age 43 ± 4.3, M/F 11/4, ISS 24.5 ± 2.5) presented during the shortest night period (10:00 pm−5:00 am). Serial blood samples were obtained (3 samples within the first 24 h and daily from days 1–7) from all patients. Thirty-two plasma inflammatory mediators were assayed. Two-way Analysis of Variance (ANOVA) was used to compare groups. Dynamic Network Analysis (DyNA) and Dynamic Bayesian Network (DyBN) inference were utilized to infer dynamic interrelationships among inflammatory mediators. Both total hospital and intensive care unit length of stay were significantly prolonged in the mNight group. Circulating IL-17A was elevated significantly in the mNight group from 24 h to 7 days post-injury. Circulating MIP-1α, IL-7, IL-15, GM-CSF, and sST2 were elevated in the mDay group. DyNA demonstrated elevated network complexity in the mNight vs. the mDay group. DyBN suggested that cortisol and sST2 were central nodes upstream of TGF-β1, chemokines, and Th17/protective mediators in both groups, with IL-6 being an additional downstream node in the mNight group only. Our results suggest that time of injury affects clinical outcomes in severely injured patients in a manner associated with an altered systemic inflammation program, possibly implying a role for diurnal or circadian variation in the response to traumatic injury.
Atlas of Differential Diagnosis in Neoplastic Hematopathology

General Histologic and Cytologic Features Lymph Node Bone Marrow Immunophenotyping Flow Cytometry Immunohistochemistry Immunophenotypic Markers: Differential Diagnosis Introduction to Cytogenetics, FISH, and Molecular Testing Cytogenetics Fluorescence In-Situ Hybridization and Polymerase Chain Reaction Mature B-Cell Neoplasms Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and B-Cell Prolymphocytic Leukemia Mantle Cell Lymphoma Marginal Zone Lymphoma Follicular Lymphoma Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia Diffuse Large B-Cell Lymphoma and its Variants Hairy Cell Leukemia Burkitt Lymphoma and B-Cell Lymphoma, Unclassifiable (with Features Intermediate between Burkitt Lymphoma and DLBCL) Plasma Cell Neoplasms B-Cell Lymphomas with Plasmablastic Morphology and/or EBV Expression Mature T-Cell Neoplasms Adult T-Cell Leukemia/Lymphoma T-Cell Prolymphocytic Leukemia and T-Cell Large Granular Lymphocyte Leukemia Peripheral T-Cell Lymphoma Angioimmunoblastic T-Cell Lymphoma Anaplastic Large Cell Lymphoma Extranodal Natural Killer/T- Cell Lymphoma, Nasal Type Hodgkin Lymphoma Classical Hodgkin Lymphoma Nodular Lymphocyte Predominant Hodgkin Lymphoma Myeloproliferative Neoplasms Introduction to Myeloproliferative Neoplasms Chronic Myeloid Leukemia Polycythemia Vera Essential Thrombocythemia Primary Myelofibrosis Other Myeloproliferative Neoplasms Myelodysplastic Syndromes and Mixed Myelodysplastic/ Myeloproliferative Neoplasms Myelodysplastic Syndromes Mixed Myelodysplastic-Myeloproliferative Neoplasms Acute Myeloid Leukemia Acute Myeloid Leukemia: Introduction Acute Myeloid Leukemia without Specific Genetic Changes Acute Myeloid Leukemia with Recurrent Genetic Abnormalities Acute Lymphoblastic Leukemia and Other Hematopoietic Tumors B-Lymphoblastic Leukemia/Lymphoma T-Lymphoblastic Leukemia/Lymphoma Other Tumors Extranodal Lymphomas and their Differential Diagnosis Body Cavities Liver Lung and Mediastinum Salivary Glands Skin Spleen Stomach and Gastrointestinal Tract Testis Index
RESEARCH STATEMENT: COMPACTIFYING RELATIVE PICARD SCHEMES

1.1. Moduli spaces and compactification. My research is in the area of algebraic geometry concerned with moduli spaces: geometric spaces whose points classify geometric objects. Moduli spaces are fundamental in all areas of modern geometry, because their geometry encodes the relationships among the objects they classify. For many applications, the usefulness of a moduli space depends on its being compact; that is, it should contain a unique limit for each family of the objects it classifies. For example, intersection theory is generally meaningful only on compact spaces. More broadly speaking, it is valuable to understand limit behavior because limit objects often shed light on the objects of which they’re the limits. But many naturally defined moduli spaces are not compact, and so it is of interest to compactify them—that is, to assign limit points to families of the objects they classify—in a geometrically meaningful way. The most famous example is probably that of the moduli space Mg of smooth algebraic curves (or Riemann surfaces) of genus g: this space is not compact, since smooth curves can be continuously deformed to singular curves. The compactification Mg of Mg, due to Deligne and Mumford in 1969, supplies limits for families of smooth curves by adding to Mg a boundary parametrizing certain singular curves (those which are Deligne-Mumford stable).
Maintenance of population structuring in sympatric-wintering populations of Greater White-fronted Geese Anser albifrons: behaviour, ecology and landscapes

Population structuring, although most common in sedentary organisms (Arguedas & Parker 2000), is well documented in migratory birds, including waterfowl (Zink 1996). In polytypic species it is generally presumed that phenotypic variation, and some level of population genetic structuring, is an outcome of natural selection, with different forms adapted to specific environments or habitats (niches). Identification and quantification of “ecotypes” is a priority among conservationists and resource managers, as maintenance of genetic diversity is a common goal in wildlife conservation (Avise & Hamrick 1996). Once distinctive forms are identified then it becomes imperative to discover the mechanisms sustaining population structure with the objective of enhancing long-term persistence. There is little empirical data on the behaviour and distribution of sympatric wintering subspecies or populations of waterfowl or documentation of potential isolating mechanisms. In North America, research on gene flow and population structuring among various forms of the Mallard Anas platyrynchos have focused on comparisons with the more geographically restricted, and habitatdependent Black Duck Anas rubripes; Merendino et al. Maintenance of population structuring in sympatric-wintering populations of Greater White-fronted Geese Anser albifrons: behaviour, ecology and landscapes
Behavioral risk factors that predispose women to vaginal infections in Turkey

Objective: Vaginal infections are common and when they are not treated, they can cause serious health problems such as getting infected with Human Immunodeficiency Virus (HIV). The aim of this study was to determine the behavioral risk factors for vaginal infections among women with and without vaginal infections. Methodology: This study was done in a large women’s hospital. The sample consisted of 200 women between the ages of 15 and 49. A pelvic examination and clinical assessment were conducted on each woman. Risk factors were analyzed through the use of cross-tabs, t-test, odds ratio and percent analysis. Results: Behaviors such as washing from back to front after defecation (OR=3.79; 95% CI, 2.05-7.01), cleaning with bare hand in the toilet (OR=4.75; 95% CI, 1.71-13.23), bathing by sitting on a stool (OR=2.64; 95% CI, 1.44-4.84, p<0.001), infrequent change of underwear (OR=6.15; 95% CI, 2.43-15.55, p<0.001) and douching after intercourse (OR=1.84; 95% CI, 1.09-3.07, p <0.05) were risk factors associated with vaginal infections. Conclusion: The results can provide physicians with the evidence based data to be used when counseling, educating and treating women for vaginal infections.
Achievements in the Topographic Design of Commercial Titanium Dental Implants: Towards Anti-Peri-Implantitis Surfaces

Titanium and its alloys constitute the gold standard materials for oral implantology in which their performance is mainly conditioned by their osseointegration capacity in the host’s bone. We aim to provide an overview of the advances in surface modification of commercial dental implants analyzing and comparing the osseointegration capacity and the clinical outcome exhibited by different surfaces. Besides, the development of peri-implantitis constitutes one of the most common causes of implant loss due to bacteria colonization. Thus, a synergic response from industry and materials scientists is needed to provide reliable technical and commercial solutions to this issue. The second part of the review focuses on an update of the recent findings toward the development of new materials with osteogenic and antibacterial capacity that are most likely to be marketed, and their correlation with implant geometry, biomechanical behavior, biomaterials features, and clinical outcomes.
A constitutive model for sands: Evaluation of predictive capability

A constitutive model to describe the mechanical behavior of sands under monotonic loading throughout the stress and strain range of engineering interest is presented. The model uses pressure-dependent elasticity, a three-invariant version of the Murata-Miura yield loci for plastic compression, an enhanced Matsuoka-Nakai criterion for inelastic shear response, and a 3D implementation of Rowe’s stress-dilatancy theory. In order to make the model useful and attractive to geotechnical engineers, its eight parameters were selected among those well known to the geotechnical community. Some numerical simulations are presented to compare the model’s performance against experimental results.
2 Lotus Cytogenetics

Most Lotus species have the basic chromosome number x = 7. The basic number x = 6 is, however, characteristic for the Corniculatus group and the other species from the section Lotus. Polyploidy, especially tetraploidy (2n = 4x), is recurrent in the genus with many species showing diploid and tetraploid accessions and others known as tetraploids only, such as L. corniculatus, the major forage crop. Genomes are relatively small, which, together with other interesting features, led to the choice of L. japonicus as a model legume species. Since then, advances in molecular cytogenetics, with the mapping of repetitive and single-copy sequences, enabled the integration of chromosomes to genetic maps and genome sequence information. Comparative cytogenetic maps were established for species from the section Lotus, mostly from the Corniculatus groups, and have demonstrated the importance of inversions and translocations, in addition to descending dysploidy and polyploidy, to the karyotype evolution of the genus.
Treatments for Poststroke Motor Deficits and Mood Disorders: A Systematic Review for the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Guidelines for Stroke Rehabilitation

Background Early rehabilitation after stroke is essential to help reduce disability. Purpose To summarize evidence on the benefits and harms of nonpharmacologic and pharmacologic treatments for motor deficits and mood disorders in adults who have had stroke. Data Sources English-language searches of multiple electronic databases from April 2009 through July 2018; targeted searches to December 2018 for studies of selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors. Study Selection 19 systematic reviews and 37 randomized controlled trials addressing therapies for motor deficits or mood disorders in adults with stroke. Data Extraction One investigator abstracted the data, and quality and GRADE assessment were checked by a second investigator. Data Synthesis Most interventions (for example, SSRIs, mental practice, mirror therapy) did not improve motor function. High-quality evidence did not support use of fluoxetine to improve motor function. Moderate-quality evidence supported use of cardiorespiratory training to improve maximum walking speed and repetitive task training or transcranial direct current stimulation to improve activities of daily living (ADLs). Low-quality evidence supported use of robotic arm training to improve ADLs. Low-quality evidence indicated that antidepressants may reduce depression, whereas the frequency and severity of antidepressant-related adverse effects was unclear. Low-quality evidence suggested that cognitive behavioral therapy and exercise, including mind-body exercise, may reduce symptoms of depression and anxiety. Limitation Studies were of poor quality, interventions and comparators were heterogeneous, and evidence on harms was scarce. Conclusion Cardiorespiratory training, repetitive task training, and transcranial direct current stimulation may improve ADLs in adults with stroke. Cognitive behavioral therapy, exercise, and SSRIs may reduce symptoms of poststroke depression, but use of SSRIs to prevent depression or improve motor function was not supported. Primary Funding Source U.S. Department of Veterans Affairs, Veterans Health Administration.
Fauna of the Kemp Caldera and its upper bathyal hydrothermal vents (South Sandwich Arc, Antarctica)

Faunal assemblages at hydrothermal vents associated with island-arc volcanism are less well known than those at vents on mid-ocean ridges and back-arc spreading centres. This study characterizes chemosynthetic biotopes at active hydrothermal vents discovered at the Kemp Caldera in the South Sandwich Arc. The caldera hosts sulfur and anhydrite vent chimneys in 1375–1487 m depth, which emit sulfide-rich fluids with temperatures up to 212°C, and the microbial community of water samples in the buoyant plume rising from the vents was dominated by sulfur-oxidizing Gammaproteobacteria. A total of 12 macro- and megafaunal taxa depending on hydrothermal activity were collected in these biotopes, of which seven species were known from the East Scotia Ridge (ESR) vents and three species from vents outside the Southern Ocean. Faunal assemblages were dominated by large vesicomyid clams, actinostolid anemones, Sericosura sea spiders and lepetodrilid and cocculinid limpets, but several taxa abundant at nearby ESR hydrothermal vents were rare such as the stalked barnacle Neolepas scotiaensis. Multivariate analysis of fauna at Kemp Caldera and vents in neighbouring areas indicated that the Kemp Caldera is most similar to vent fields in the previously established Southern Ocean vent biogeographic province, showing that the species composition at island-arc hydrothermal vents can be distinct from nearby seafloor-spreading systems. δ13C and δ15N isotope values of megafaunal species analysed from the Kemp Caldera were similar to those of the same or related species at other vent fields, but none of the fauna sampled at Kemp Caldera had δ13C values, indicating nutritional dependence on Epsilonproteobacteria, unlike fauna at other island-arc hydrothermal vents.