Miracle-dz/UniFAR-FTUs huggingface dataset:
Longitudinal Tumor Size and Neutrophil‐to‐Lymphocyte Ratio Are Prognostic Biomarkers for Overall Survival in Patients With Advanced Non‐Small Cell Lung Cancer Treated With Durvalumab

Therapy optimization remains an important challenge in the treatment of advanced non‐small cell lung cancer (NSCLC). We investigated tumor size (sum of the longest diameters (SLD) of target lesions) and neutrophil‐to‐lymphocyte ratio (NLR) as longitudinal biomarkers for survival prediction. Data sets from 335 patients with NSCLC from study NCT02087423 and 202 patients with NSCLC from study NCT01693562 of durvalumab were used for model qualification and validation, respectively. Nonlinear Bayesian joint models were designed to assess the impact of longitudinal measurements of SLD and NLR on patient subgrouping (by Response Evaluation Criteria in Solid Tumors 1.1 criteria at 3 months after therapy start), long‐term survival, and precision of survival predictions. Various validation scenarios were investigated. We determined a more distinct patient subgrouping and a substantial increase in the precision of survival estimates after the incorporation of longitudinal measurements. The highest performance was achieved using a multivariate SLD and NLR model, which enabled predictions of NSCLC clinical outcomes.
The effect of some additives on the closed bomb burning and ignitability of RDX/TNT (60/40)

Abstract The burning and ignition properties of Composition (Comp) B are studied so that formulation modification could be made that would reduce gun projectile in-bore thermal explosions. Comp B first burns on its surface like a gun propellant; then, at a pressure near 100 MPa, a sudden breakup burning phase develops. New surface area is created at a phenomenal rate, and this is the cause of the catastrophic reaction rates that it can experience. Coating its RDX constituent with a protectant significantly slows this reaction rate. It appears to do this by inhibiting the rate at which the RDX is released from the TNT matrix for burning, probably by infinitesimally delaying the ignition of the RDX in the particle ignition sequence. A new test that evaluates explosive ignitability as a function of pressure and energy indicates that an RDX protective coating may also increase the level of thermal ignition and delay the onset of a thermal explosion. Collectively, these three desirable properties, caused by a .
Crystallization kinetics of poly(1,4-butylene-co-ethylene terephthalate)

The crystallization kinetics of poly(butylene terephthalate) (PBT), poly(ethylene terephthalate) (PET), and their copolymers poly(1,4-butylene-co-ethylene terephthalate) (PBET) containing 70/ 30, 65/35 and 60/40 molar ratios of 1,4-butanediol/ethylene glycol were investigated using differential scanning calorimetry (DSC) at crystallization temperatures (T c ) which were 35-90 C below equilibrium melting temperature T°m. Although these copolymers contain both monomers in high proportion, DSC data revealed for copolymer crystallization behaviour. The reason for such copolymers being able to crystallize could be due to the similar chemical structures of 1,4-butanediol and ethylene glycol. DSC results for isothermal crystallization revealed that random copolymers had a lower degree ofcrystallinity and lower crystallite growth rate than those ofhomopolymers. DSC heating scans, after completion of isothermal crystallization, showed triple melting endotherms for all these polyesters, similar to those of other polymers as reported in the literature. The crystallization isotherms followed the Avrami equation with an exponent n of 2-2.5 for PET and 2.5-3.0 for PBT and PBETs. Analyses of the Lauritzen-Hoffman equation for DSC isothermal crystallization data revealed that PBT and PET had higher growth rate constant G o , and nucleation constant K g than those of PBET copolymers.
Localization of Energy in Organic Molecules as Revealed by Dynamic Nuclear Polarization of Diphenylpicrylhydrazyl in Polystyrene

The model of the free radical in an amorphous polystyrene matrix was studied by dynamic polarization to obtain insight into transfer of electron spin energy into thermal energy. A solid‐state effect was obtained for protons in 5% DPPH in polystyrene at 9.5 GHz at liquid‐helium, liquid‐nitrogen, and even at room temperature with ordinary microwave power. The proton spin relaxation took place by spin‐diffusion mechanism. The electron spin relaxation took place by direct process from liquid‐helium to room temperature suggesting that the slow step in the electron spin relaxation took place in the molecule of the DPPH rather than in the polystyrene. The results obtained indicate possibilities of further enhancing nuclear orientation for nuclear reaction by modification of free radical and for constructing model systems for energy storage useful in catalysis and biochemical enzyme reactions.
Equation of state for the Lennard-Jones fluid

Molecular dynamics calculations of the pressure and configurational energy of a Lennard-Jones fluid are reported for 108 state conditions in the density range 0·35 ≦ ρ* ≦ 1·20 and temperature range 0·5 ≦ T* ≦ 6 (where ρ* = ρσ3, T* = kT/e). Particular attention is paid to the dense fluid region (ρ* ≧ 0·9), including state conditions in the subcooled liquid region. These new simulation results for P and U are combined with those of previous workers, together with low density values calculated from the virial series and values of the second virial coefficients themselves, to derive an equation of state for the Lennard-Jones fluid that is valid over a wide range of temperatures and densities. The equation of state used is a modified Benedict-Webb-Rubin equation having 33 constants. It fits the data well over the density range 0 ≦ ρ* ≦ 1·2 and for T* values ranging from 0·5 to 6·0 (the exact temperature range depending to some extent on the density considered). We also calculate for the same range of state con.
Electronic Journal of Qualitative Theory of Differential Equations

The main purpose of this paper is to establish a global smooth linearization result for two classes of nonautonomous dynamics with discrete time. More precisely, we consider a nonlinear and nonautonomous dynamics given by a two-sided sequence of maps as well as variational systems whose linear part is contractive, and under suitable assumptions we construct C1 conjugacies between the original dynamics and its linear part. We stress that our dynamics acts on a arbitrary Banach space. Our arguments rely on related results dealing with autonomous dynamics.
Molecular Network Analysis in Rabies Pathogenesis Using Cooperative Game Theory

Background and Purpose: Recently, many researchers from different fields of science have been used networks to analyze complex relational big data. The identification of which nodes are more important than the others, known as centrality analysis, is a key issue in biological network analysis. Although, several centralities have been introduced degree, closeness, and betweenness centralities are the most popular. These centralities are based on the individual position of each node and the cooperation and synergies between nodes have been ignored Objectives: Since in many cases, the network function is a consequence of cooperation and interaction between nodes, classical centralities were extended to a group of nodes instead of only individual nodes using cooperative game theory concepts. In this study, we analyze the protein interaction network inferred in rabies disease and rank gene products based on group centrality measurements to identify the novel gene candidates Materials and Methods: For this purpose, we used a game-theoretic approach at three scenarios, where the power of a coalition of genes assessed using different criteria including the neighbors of genes in the network, and predefined importance of the genes in its neighborhood. The Shapley value of such a game was considered as a new centrality. In this study, we analyze the network of gene products implicates rabies. The network has 1059 nodes and 8844 edges and centrality analysis was performed using CINNA package in R software Results: Based on three scenarios, we selected genes among the highest Shapley value that had low ranking from classical centralities. The enrichment analysis among the selected genes in scenario 1 indicates important pathways in rabies pathogenesis. Pair-wise correlation analysis reveals that changing the weights of nodes at different scenarios can significantly affect the results of ranking genes in the network Conclusion: A prior knowledge about the disease and the topology of the network, enable us to design an appropriate game and consequently infer some biological important nodes (genes) in the network. Obviously, a single centrality cannot capture all significant features embedded in the network.
An analysis of YouTube comments on BTS using text mining

ABSTR ACT In this study, I applied text mining methods to the analysis of comments to examine people’s thoughts regarding BTS. I analysed approximately 100,000 comments left on YouTube videos of or about BTS. As indicated in the results of the TF-IDF analysis, the designation “people / person” is reflective of the foundations of commenters’ perceptions of BTS. Through various contents, BTS has shown people their sincerity and cheerful side. People have familiarised themselves with BTS via such videos and thereby have come to perceive the group members as being the same kind of people as the viewers are. Of course, people have focused on different aspects of BTS. As shown in the topic modeling results, some have focused on the chemistry among the members, while others have concentrated on the appeal of their favourite members. However, regardless of their area of focus, people have shared a sense of togetherness with the group and have empathised with the lives of its members. Furthermore, they have been moved by the group’s dedication and growth, expressing support for its members’ hearts and thoughts. Also, network analysis results indicated that people have felt that BTS deserves their success based on the group’s teamwork, character, and performances. People have also recognised that their music is an outgrowth of their dedication and passion.
Causes and Characteristics of Peri-Orbital Contusions and Their Relationship with Intracranial Injuries in Inward Patients in Two Tertiary Care Hospitals in Sri Lanka

Introduction: The peri-orbital contusion (PC) is a common injury in day to day surgical casualties. It is a common injury observed in patients who are in an unconscious state following head injuries. The aim of the study is to describe characteristics of PC and understand its relationship with associated injuries, especially with facial injuries and intracranial injuries. Methods: This retrospective study reviewed the medico-legal examination forms (MLEF) of 67 inward patients in Teaching Hospital, Karapitiya and District General Hospital, Matara with peri-orbital contusions following trauma during a period of six months from January 2020 to June 2020. Results: A total number of 67 patients were included with 81% being male patients. The commonest soft tissue injuries around the PCs were abrasions (n=39, 71%) and 25 (38%) of the study sample had fractures of the skull. The majority (n=22, 88%) of them had fractures of facial bones followed by vault and basal skull fractures. The majority of PCs (45%) were blue in colour and only 8% were red. The red colour was observed only in PCs of less than 24 hours. The main cause for PC was due to direct blow to the eye while the rest (n=29, 45%) were due to the indirect blow. A higher incidence of fracture of the head was observed in assaults (39%). Conclusions: The commonest cause for the black eye in the study sample was the direct blow with a blunt force in an assault. The red colour was observed in PC of less than 24 hours duration. The PC had not caused major injuries to the eye but there was frequent involvement of facial bone fractures.
Measure of noncompactness for nonlinear Hilfer fractional differential equation with nonlocal Riemann–Liouville integral boundary conditions in Banach spaces

This paper investigates the existence results and uniqueness of solutions for a class of boundary value problems for fractional differential equations with the Hilfer fractional derivative. The reasoning is mainly based upon Mönch’s fixed point theorem associated with the technique of measure of noncompactness. We illustrate our main findings, with a particular case example, included to show the applicability of our outcomes. The boundary conditions introduced in this work are of quite general nature and reduce to many special cases by fixing the parameters involved in the conditions.
Why We Should Build Robots That Both Teach and Learn

In this paper, we argue in favor of creating robots that both teach and learn. We propose a methodology for building robots that can learn a skill from an expert, perform the skill independently or collaboratively with the expert, and then teach the same skill to a novice. This requires combining insights from learning from demonstration, human-robot collaboration, and intelligent tutoring systems to develop knowledge representations that can be shared across all three components. As a case study for our methodology, we developed a glockenspiel-playing robot. The robot begins as a novice, learns how to play musical harmonies from an expert, collaborates with the expert to completeharmonies, and then teaches the harmonies to novice users. This methodology allows for new evaluation metrics that provide a thorough understanding of how well the robot has learned and enables a robot to act as an efficient facilitator for teaching across temporal and geographic separation. CCS CONCEPTS •Human-centered computing →Collaborative and social computing systems and tools.
JASMONATES: MULTIFUNCTIONAL BIOMOLECULES IN PLANTS

Jasmonates (JA’s) have been proposed to be affecting a variety of plant processes ranging from normal vegetative and reproductive development to even defense against various abiotic stresses JA’s structurally are, cyclopentanone derivates of α-linolenic acid. The precursor is linolenic acid released from the membrane bound lipids which is then converted to jasmonic acid via a series of steps called octadecanoid pathway. Although there has been an increase in the interest regarding these molecules and their role in plants but these are certainly still underexploited biomolecules and more elaborate studies regarding their molecular mechanisms and physiological functions are required.
A Study of Perceptions of Organization’s Strategies for Competition in Markets

As companies are confronting fierce competition in markets, it is necessary for executive to formulate effective and proper strategies to deal efficiently with the circumstance. The strategies should help companies keep up with changing demands of customers to generate competitive advantage. It is, therefore, interesting to study strategies of organizations for competition in markets in order to assist executives to understand thoroughly the situation. The study focuses on Thai consumers and uses questionnaire survey as a main method for primary data collection. From the study, the strategies that are perceived to be highly important for consumers are Convenience, Services, Warranty and Certification. Further, innovations and excellent designs that can create uniqueness are also substantial. Further, Electronic Channels and Online Social Networking are considered important as they are consistent with the lifestyles of customers. With regard to the application level, the strategies that are perceived to be frequently employed in markets are social networking, Convenience, Cutting edge technology and Packaging development. In addition, some strategies that have high potential to be further applied are Customisation and Joint Development with Customers as the strategies can attract more attention of customers and satisfy their particular needs in the future.
Comparison of contrast sensitivity in Myopes and Hyperopes

University of Lahore, Pakistan. *Corresponding Author E-mail: samiaiqbal988@gmail.com To compare contrast sensitivity in myopes and hyperopes and the evaluation of diffrences in contrast sensitivity in different degrees of myopic and hyperopic correction. A comperitive cross sectional study was conducted on 31 patients having different degrees of myopia and hyperopia to assess its effects on contrast sensitivty. Visual acuties for distance and near was measured by using distance snellen chart at 6m and near vision chart at 33cm. Contrast sensitivity was measured by using Pelli Robson contrast sensitivity chart. Results showed us that contrast sensitivity effect ratio was more in hyperopes as compared to myopes . Moreover myopes with mild to moderate degree showed normal contrast sensitivity while contrast sensitivity was reduced on severe myopes. Hyperopes showed decreased contrast sensitivity then myopes. Binocular contrast sensitivity was better than monocular contrast sensitivity. It was concluded that hyperopes showed more reduction in contrast sensitivity as compared to myopes. Mild to moderate degree of myopes and hyperopes showed better contrast sensitivity without any optical correction. Severe degree of such refractive errors showed decreased contrast sensitivity. Binocular contrast sensitivity was much better than monocular contrast sensitivity.
Reexamination of the determinants of firms’ growth in periods of crisis

The recent financial crisis has underlined the necessity to recognize why some firms and economies are more severely affected while others are more resilient to crisis and how different financial characteristics affect firms’ growth path. In order to explore these issues empirically, we reexamine the determinants of corporate growth during the crisis and post-crisis period (2008-2013) on the sample of 10 Central and East European countries belonging to two different regional groups – “Visegrad four” and the group of former Yugoslavian countries. Our analysis covers the sample of 3,660 firm-year observations. We model firm growth as a function of two country-specific variables (inflation and capital market liquidity) and four company-specific variables (financial leverage, asset turnover, profit margin and ratio between cash flow and assets). Our study indicates the importance of infrastructure prerequisites and macroeconomic policies for the companies’ growth in the conditions of crisis. Our results reveal a specific relation between leverage and firm growth during the crisis period, whereby the impact of leverage is perceived by a comprehensive result of the degree of firm indebtedness, the level of capital market development, the position of banking sector and the cost of debt. Finally, our results show some intriguing patterns in firm profitability – growth as well as asset efficiency – growth relation.
Model of laser-driven mass transport in thin films of dye-functionalized polymers

Based on Newtonian fluid dynamic relations, a model is constructed to describe laser-induced mass transport in thin films of polymers containing isomerizable azobenzene chromophores, in which surface profile diffraction gratings can be inscribed with an interference pattern of coherent light. The Navier–Stokes equations for laminar flow of a viscous fluid are developed to relate velocity components in the film to pressure gradients in the polymer film, by definition of boundary layer conditions. This general laminar flow model is applicable to the formation of surface gratings through a variety of mechanisms. Considering the mechanism of an isomerization-driven free volume expansion to produce internal pressure gradients, a specific model is developed to describe polymer flow resulting from laser-induced isomerization of the bulky chromophores. This yields an expression relating the time evolution of the surface gratings to properties which could be varied experimentally, such as those of the irradiating .
Validation of broken-symmetry density functional methods for the calculation of electron paramagnetic resonance parameters of dinuclear mixed-valence MnIVMnIII complexes

The EPR parameters of a series of dinuclear manganese(III,IV) complexes with mono(μ-oxo), bis(μ-oxo), (μ-oxo)(μ-carboxylato), bis(μ-oxo)(μ-carboxylato), and (μ-oxo)bis(μ-carboxylato) bridges were studied by broken-symmetry density functional (DFT) methods. The influence of the exchange-correlation functional on the agreement with experiment has been evaluated systematically for g tensors; 55Mn, 14N, and 1H hyperfine coupling tensors; and Heisenberg exchange couplings. 14N and 1H hyperfine couplings, 55Mn hyperfine anisotropies, g tensors, and exchange couplings are well described by hybrid functionals with moderate exact-exchange admixtures such as B3LYP. The isotropic 55Mn hyperfine couplings require larger exact-exchange admixtures. However, the errors of the B3LYP calculations are systematic and may be corrected by a constant scaling factor, providing good predictive power for a wide range of EPR parameters with broken-symmetry DFT and standard functionals. The influence of terminal and bridging liga.
Plasmodium falciparum Parasitaemia during Pregnancy and the Use of Malaria Prevention Methods by Women Attending Antenatal Consultation at the Regional Hospital Bamenda, Northwest Cameroon

Aims: The aims of this study were to determine the prevalence of Plasmodium falciparum parasitaemia in pregnant women and to identify the prevention methods used by pregnant women attending antenatal consultation (ANC) in the Regional Hospital Bamenda (RHB). Study Design: This was a hospital based cross sectional study. Place and Duration of Study: This study was carried out in the Regional Hospital Bamenda between April and May 2020. Methodology: A structured questionnaire was used to collect information on sociodemographic characteristics, history of pregnancy and the use of malaria prevention methods. Capillary blood was collected through finger prick and used to prepare thick and thin blood smears that were Giemsa-stained for the detection of malaria parasite by microscopy. Results: A total of 250 pregnant women took part in this study. The mean age ±SD was 27.71 ±5.47 years. The mean pregnancy age ±SD was 24.04 ±8.59 weeks. The prevalence of malaria parasitaemia was 18.0%. The most used malaria prevention method was LLINs (190/211, 91.0%). There was a statistically significant difference in MP prevalence between women who used IPTp (13.9%) and those who didn’t (26.5%) (χ2 =5.87, P= .02); between women who used bed nets and IPT (12.9%) in combination and those who didn’t (24.0%) (χ2 = 5.12, P= .03) as well as between participants who used at least one method (16.4%) and their counterparts who didn’t use any malaria prevention method (38.9%) (χ2=5.73, P=.01). Living in a house with plank or mud walls (13; 29.0%) was surprisingly more protective than living in a cement brick or mud brick house (30; 71.0%) (OR: 2.34; 95%CI: 1.10-4.97; P=.03). Conclusion: Malaria remains a health preoccupation among pregnant women attending ANC consultation in the RHB. Use of bed nets and IPTp as well as the use of at least one prevention method could be protective.