Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Identification of Mental Health Needs for Children in Care: A Therapeutic Assessment Programme for Statutory Clients of Child Protection

Infants, children and young people enter out of home care in distressing circumstances. They have often suffered traumatic experiences and have had their primary relationships disrupted. They and their families and carers have specific mental health needs at this time but few have attended a mental health service. A systematic comprehensive therapeutic assessment approach is described for all child protection clients who entered out-of-home care for the first time in one calendar year. The work of the programme is described using both case study and assessment findings. More than 60 per cent of participants met criteria for a major psychiatric diagnosis, with Post Traumatic Stress and Adjustment Disorders being the most common diagnostic categories. Nearly three-quarters of participants over the age of 5 years scored in the borderline or abnormal range on the Strengths and Difficulties Questionnaire (SDQ; Goodman, 1997). There was an over-representation of infants less than 1 year of age and adolescents in the cohort, representing particular developmental challenges. The findings are discussed within the context of specific mental health service delivery to this vulnerable population of maltreated infants, children and young people.
A New Watermarking Protocol of Copyright Protection

Most existing watermarking protocols deal with the copyright protection as a transaction between the seller and the buyer. However, these protocols don.t appropriately resolve the copyright problem of copyright authority, copyrighter, ICP and customer. To address this issue, a new watermarking protocol proposed in this article uses three watermarks in structure. By introducing the CA, the signature and the timestamp, the protocol sets up a hiberarchy of digital copyright authorities to protect rights, defends ambiguity attacks and collusive attacks, and resolves the non-repudiation problem and CS overload problem. Because ICP and customer cannot remove the watermark from watermarked digital content, and neither the copyrighter nor the ICP can fabricate piracy, the proposed protocol can trace piracy. With the proxy signature, the digital content transaction without the Third party is performed in which there are only two participants, the seller and the buyer.
Influence of tannic acid and polyethylene glycol on the excretion and digestibility of amino acids in gelatin-fed broilers

1. A precision feeding experiment was conducted to evaluate the effects of tannic acid (TA) and polyethylene glycol (PEG) on the excretion of amino acids, and the apparent and true digestibility of gelatin protein in broilers. 2. In a 3 × 2 × 2 factorial design, ninety-six 7-week-old broiler cockerels in 8 replicates of 12 treatments, were fed on warm solution of gelatin alone (0, 6 or 12 g/50 ml/bird, Treatments 1–3), or gelatin with TA solution (4·5 g TA/10ml/bird, Treatments 4–6) and PEG solution (2 g/10 ml/bird, Treatments 7–12). Total excreta were collected for 48 h and the amino acid contents of gelatin and excreta were determined. 3. In the absence of TA, the digestibility of gelatin was almost complete. TA increased the excretion of amino acids from gelatin-fed birds to varying extents. Although the digestibility of all indispensable and dispensable amino acids was adversely affected by the presence of TA, increasing the amount of gelatin from 6 to 12 g improved the apparent and true digestibility of amino acids. PEG reduced the excretion of amino acids and improved the digestibility of amino acids in gelatin in TA-dosed birds. However, the effect was greater when the lesser amount of gelatin was fed. 4. In conclusion, PEG seemed to play an important role in reducing the effect of dietary tannins in the gastrointestinal tract of birds fed on diets high in tannins and improved protein digestibility and utilisation, particularly when the diet was low or marginal in protein.
The Internet of Things on Its Edge: Trends Toward Its Tipping Point

In this article, a review of commercial devices on the edge of the Internet of Things (IoT), or IoT nodes, is presented in terms of hardware requirements. IoT nodes are the interface between the IoT and the physical world (e.g., sensor nodes). To this aim, we introduce a wide survey of existing devices made publicly available for the further analysis of trends and state of the art. This data-driven approach permits developing quantitative insight into the big picture of the current status of IoT nodes. The analysis shows that an order (ultimately two orders) of magnitude gap needs to be filled in terms of size, lifetime, and cost (energy efficiency) to ultimately make IoT nodes truly ubiquitous and trigger the widely expected exponential growth of the IoT ecosystem. Overall, this article presents a view from the edge of the IoT and a glimpse of its tipping point.
HIV-associated sensory neuropathies

Peripheral neuropathy has emerged as the most common neurological complication of HIV infection [1– 4]. There are several discrete types of HIV-associated neuropathy, which can be classified according to the timing of their appearance during HIV infection, their etiology and whether they are primarily axonal or demyelinating (Table 1). Some represent a consequence of HIV infection producing neuropathological damage [e.g., distal symmetrical polyneuropathy (DSP)], while others are related to opportunistic pathogens [e.g., cytomegalovirus (CMV) polyradiculitis]. An increasingly common group is that which occurs as a result of treatment toxicity [e.g., toxic neuropathy from antiretroviral drugs (TNA) and lactic acidosis syndrome].
Whither the role of private foundations in support of international security policy?

Since the 1970s, a relatively small group of private foundations in the United States have helped to shape the public debate in the international security field through systematic grantmaking around such issues as peace studies, conflict resolution, arms control, non-proliferation and regional security. These organizations include some of the largest and most well known eleemosynary institutions in the world—such as the Ford, MacArthur and W. Alton Jones Foundations; the Rockefeller Brothers Fund and John Merck Fund; and the Carnegie Corporation of New York—as well as a number of smaller but nonetheless influential flinders, such as the Compton, Prospect Hill, Samuel Rubin, Scherman and Winston Foundations and the Ploughshares Fund.
Pre- and Postinvasion Defenses Both Contribute to Nonhost Resistance in Arabidopsis

Nonhost resistance describes the immunity of an entire plant species against nonadapted pathogen species. We report that Arabidopsis PEN2 restricts pathogen entry of two ascomycete powdery mildew fungi that in nature colonize grass and pea species. The PEN2 glycosyl hydrolase localizes to peroxisomes and acts as a component of an inducible preinvasion resistance mechanism. Postinvasion fungal growth is blocked by a separate resistance layer requiring the EDS1-PAD4-SAG101 signaling complex, which is known to function in basal and resistance (R) gene–triggered immunity. Concurrent impairment of pre- and postinvasion resistance renders Arabidopsis a host for both nonadapted fungi.
Financial Reporting in Maltese Voluntary Organisations

In this paper we analyse the adequacy and effectiveness of the legal aspects of the current Maltese voluntary organisations' (VOs) regulatory framework, the guidelines and best practices being adopted by Maltese charities in compiling their financial reports. In doing this we also look at the key operational internal control and other challenges being faced by such VOs in complying with the existing regulatory framework. Data is also gathered through the responses of an online questionnaire, which we distributed to enrolled VOs and through responses of semi-structured interviews carried out with the financial administrators of eleven large charities. Findings reveal that while the existing VO regulatory framework was a considerable improvement, changes are still necessary since gaps still remain and need to be resolved. This study contributes to the enhancement of the Maltese VO regulation by identifying and highlighting these gaps and providing recommendations to mitigate and resolve them.
Détection d'objets enfouis sous des surfaces rugueuses

Ce travail s'inscrit dans le cadre de la detection electromagnetique d'objets enfouis sous une surface rugueuse, et en particulier de mines antipersonnel. Cette etude a ete realisee au sein de l'Institut Fresnel, a l'aide d'un financement de la D. G. A. (Delegation generale pour l'armement). L'objet de cette these est de concevoir une methode de detection electromagnetique d'objets enfouis a faible profondeur, a l'aide d'une ligne de mesure situee a proximite de la surface. Les frequences des signaux emis par ces antennes se situant autour du domaine de resonance de l'objet (environ 1 GHz). La methode de fonctions de correlation proposee permet d'obtenir une grandeur de detection en correlant directement les champs mesures. Ces fonctions de correlation sont en fait similaires aux fonctions de Wigner-Ville, frequemment utilisees en traitement du signal. Une fois l'objet detecte, des fonctions de correlation sont utilisees dans un probleme d'inversion, c'est a dire de caracterisation de l'objet (forme, proprietes physiques,. . . ). L'utilisation de ces fonctions de correlations permet alors d'ameliorer le processus de reconstruction par rapport a une inversion classique, a partir de champs. Par ailleurs, l'utilisation de fonctions de correlation modifiees permet d'obtenir une estimation de la rugosite au dessus de l'objet. Cette connaissance, incorporee dans le processus d'inversion, ameliore aussi la reconstruction de l'objet
Time reversal location of glacial earthquakes

In 2003, Ekstrom et al. reported the detection and location of a new class of earthquakes occurring in the polar regions of the Earth. The proposed source mechanism involves large and sudden sliding motions of glaciers, which gave the name “glacial earthquakes” to these events. In this study we localize some of these earthquakes with a time reversal mirror (TRM) algorithm, which, contrary to ordinary back projection methods, does not involve testing each possible source location. In TRM localization, an earthquake is located on the basis of only one 3-D spectral element simulation of seismic wave propagation by using the full complexity of recorded data as simultaneous time-reversed sources. We show that on the basis of this approach, even glacial earthquakes with a faint signal can be correctly localized and that the pattern of the time-reversed wavefield is coherent with the motion of glaciers down their valley.
Tissue Factor Expression during Monocyte-Macrophage Differentiation

Summary Tissue factor (TF), the high affinity receptor and cofactor of factor VII, is considered as the main procoagulant in stimulated monocytes and macrophages. We studied the effect of longterm culture (differentiation) on “spontaneous” and induced (LPS) expression of TF (mRNA, antigen, cell surface associated Vlla-cofactor activity) in isolated human monocytes. TF was expressed transiently in monocytes cultured on Teflon membranes (suspension monocytes, Mo-S) and on plastic dishes (adherent monocytes, Mo-A), reaching maximal levels between days 3 and 5. Increased expression of TF was accompanied by increased stable expression of macrophage specific markers (CD71, the mannose receptor, the scavenger receptor). Bacterial lipopolysaccharide (LPS) induced (additional) TF mRNA, antigen, and activity in both Mo-S and Mo-A. In Mo-S and Mo-A of days 3 to 5, the period in which there was “spontaneous” expression of TF, TF response to LPS was considerably lower. It is concluded that during monocyte-macrophage transition, TF is “spontaneously” and transiently expressed and that with respect to TF induction the responsiveness of the cells to LPS is maintained.
Does Foreign Bank Entry Affect Domestic Enterprise Innovation?

ABSTRACT How does financial opening-up impact the real economy? The answer is important to China, the largest economy in transition experiencing a critical period of further reform of the financial system. We capture the influence of financial reform through foreign bank entry in this paper. Starting with a description of the process of foreign bank entry in China, we sum up two paths through which foreign bank entry affects China’s domestic enterprise innovation: the direct effect and the spillover effect. Then, using the data of public listed companies in China from 2001 to 2014, we investigate the effects of foreign bank entry on domestic enterprise innovation by exploiting the staggered multiple exogenous shocks and using a difference-in-difference approach. The results show that foreign bank entry contributes significantly to domestic enterprise innovation, and they are robust when considering the potential concerns of omitted variables and reverse causality. Further study illustrates that the nurturing role derives not only from the direct effect (although it is very limited), but also from the spillover effect of foreign bank entry by enhancing competition among domestic banks. The findings suggest that it is necessary to mitigate the barriers to foreign banks and expand the banking sector in China.
Reversal of acute exacerbations of chronic obstructive lung disease by inspiratory assistance with a face mask.

BACKGROUND Patients with acute exacerbations of chronic obstructive pulmonary disease may require endotracheal intubation with mechanical ventilation. We designed, and here report on the efficacy of, a noninvasive ventilatory-assistance apparatus to provide inspiratory-pressure support by means of a face mask. METHODS We assessed the short-term (45-minute) physiologic effects of the apparatus in 11 patients with acute exacerbations of chronic obstructive pulmonary disease and evaluated its therapeutic efficacy in 13 such patients (including 3 of the 11 in the physiologic study) who were treated for several days and compared with 13 matched historical-control patients. RESULTS In the physiologic study, after 45 minutes of inspiratory positive airway pressure by face mask, the mean (+/- SD) arterial pH rose from 7.31 +/- 0.08 to 7.38 +/- 0.07 (P less than 0.01), the partial pressure of carbon dioxide fell from 68 +/- 17 mm Hg to 55 +/- 15 mm Hg (P less than 0.01), and the partial pressure of oxygen rose from 52 +/- 12 mm Hg to 69 +/- 16 mm Hg (P less than 0.05). These changes were accompanied by marked reductions in respiratory rate (from 31 +/- 7 to 21 +/- 9 breaths per minute, P less than 0.01). Only 1 of the 13 patients treated with inspiratory positive airway pressure needed tracheal intubation and mechanical ventilation, as compared with 11 of the 13 historical controls (P less than 0.001). Two patients in each group died. As compared with the controls, the treated patients had a more transient need for ventilatory assistance (3 +/- 1 vs. 12 +/- 11 days, P less than 0.01) and a shorter stay in the intensive care unit (7 +/- 3 vs. 19 +/- 13 days, P less than 0.01). CONCLUSIONS Inspiratory positive airway pressure delivered by a face mask can obviate the need for conventional mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease.
Interaction between Active Pak1 and Raf-1 Is Necessary for Phosphorylation and Activation of Raf-1*

Activation of Raf-1 is a complex process in which phosphorylation of Ser338–Tyr341 is a critical step. Previous studies have shown that Pak1/2 is implicated in both Ras-dependent and -independent activation of Raf-1 by phosphorylating Raf Ser338. The present study explores the structural basis of Raf-1 phosphorylation by Pak1. We found that Pak directly associates with Raf-1 under both physiological and overexpressed conditions. The association is greatly stimulated by 4β-12-O-tetradecanoylphorbol-13-acetate and nocodazole and by expression of the active mutants of Rac and Ras. The active forms of Pak generated by mutation of Thr423 to Glu or truncation of the amino-terminal moiety exhibit a greater binding to Raf than the wild type, whereas the kinase-dead mutant Pak barely binds Raf. The extent of binding to Raf-1 is correlated with the ability of Pak to phosphorylate Raf and induce mitogen-activated protein kinase activation. Furthermore, the Raf-1 binding site is defined to the carboxyl terminus of the Pak catalytic domain. In addition, our results suggest that the amino-terminal regulatory region of Raf inhibits the interaction. Taken together, the results indicate that the interaction depends on the active conformations of Pak and Raf. They also argue that Pak1 is a physiological candidate for phosphorylation of Raf Ser338 during the course of Raf activation.
The Genetics of Keratoconus

Abstract Keratoconus is a bilateral, non-inflammatory corneal ectasia characterized by progressive conical thinning and protrusion of the cornea. Its etiology has long been believed to be multifactorial, with environmental, behavioral, and genetic factors all contributing to the disease process. This review focuses specifically on examining the evidence that supports a genetic basis for keratoconus.
Assessing the level of adaptation of employees to the transformation processes in the company

In this article, the methodical principles for assessing the level of adaptation of employees to the transformational changes in the company have been improved, which are based on the construction of a fivevector map of the readiness of the company's personnel to change. This five-vector map is presented as a decomposition of the following parameters: gender-age structure, level of qualification, motivation, productivity and corporate commitment of the personnel. Each of the five parameters of staff characteristics is further described with the help of four relevant indicators. The formalization of the selected parameters is carried out by multiplicative convolution of the indicators of their characteristics, normalized by the logistic method. The proposed model allows to determine the percentage of employees' readiness for transformational changes in the company, to establish the current dynamics of adjustment of the personnel of the investigated company to the transformational changes in the economy and society relative to the previous year or the standard, to identify the necessary tools for activating the company's personnel management policy.
Direction gravitaire visuelle: rôle de la perception d'orientation corporelle

Ce travail doctoral s'interesse a la contribution de la perception d'orientation corporelle dans la lecture visuelle de la direction gravitaire en situation d'inclinaison corporelle en roulis (effet Aubert-Muller). Il s'agit plus precisement de verifier l'hypothese physiologique d'une explication des effets Aubert par une sous-estimation de la perception d'orientation corporelle. Les deux premieres experiences montrent que les informations somesthesiques participent de facon differenciee au jugement de verticalite. Si l'interoception gastrique contribue directement a la lecture gravitaire, la somesthesie tactile serait impliquee dans la perception de l'orientation corporelle dans le champ gravitaire. Au regard des resultats obtenus dans une deuxieme serie d'experiences, il n'est pas possible de confirmer l'interpretation physiologique de l'effet Aubert. Il apparait cependant que les sujets effectueraient des calculs d'angles dans les espace corps/gravite et corps/objet et que des erreurs de perception de ces angles contribueraient aux erreurs de perception de la direction de la direction gravitaire. Une derniere experience suggere qu'un decalage illusoire de la reference egocentree dans le sens de l'inclinaison corporelle serait impliquee dans la perception des espaces corps/gravite et corps/objet. Les informations somesthesiques tactiles pourraient contribuer a la deviation de la perception de la reference egocentree.
Long-Lived Messenger RNA: Evidence from Cotton Seed Germination

In germinating cotton embryos the partial inhibition of RNA synthesis by actinomycin D does not inhibit the incorporation of leucine-14C into soluble protein nor cause a loss of polyribosomes during the first 16 hours of germination. This suggests that the protein synthesis observed during this period is directed by messenger RNA which exists in the mature seed and which is not rapidly degraded and resynthesized.
Caracterización proteica del suero del ave Coragyps atratus (zamuro de cabeza negra) y algunos estudios inmunoserológicos

El zamuro sobrevive al constante ataque infeccioso dado por su alimentacion. Determinaciones biologicas en esta especie son escasas. Se caracterizo el contenido proteico serico y se realizo el serodiagnostico para determinar anticuerpos contra agentes patogenos de interes medico, veterinario y epidemiologico. La concentracion de Proteinas Totales (PT) se determino por refractometria. En la obtencion del patron proteico se utilizo la tecnica de EPAC. Los electroforegramas se obtuvieron por densimetria. Se utilizo pruebas de aglutinacion en placa, M. gallisepticum, S. pullurum y B. abortus. Inhibicion de la hemoaglutinacion, enfermedad de New Castle (EN) y hemoaglutinacion indirecta, T. gondii. El nivel de PT fue 4.8 f 0.9 g/dL.n=35, valor superior al reportado por Coleman, 1988, n=45,4 4.2 f 0.07 g/dL. El patron general consta de 4 bandas. ALB. G. ci 2, G & y G. V con elevacion de 2. La G.l esta ausente. Alta positividad, n=45, se observo para micoplasma, 71.1% (32%,1 : l o ) y toxoplasma, 66.7%. En salmonella y brucella se obtuvo el 2.2%. Para EN no se observaron anticuerpos. En ensayos de inmunizacion activa con la vacuna de EN se evidencio la produccion de anticuerpos. La alta concentracion de α 2 representaria aumento de proteinas especificas asociadas a infecciones agudas y patologias en otros animales y el hombre. Los componentes Cg y C4 del complemento podrian intervenir en el incremento de a 2. La prevalencia de reactivaciones en la naturaleza y la demostracion de anticuerpos posterior a la inmunizacion sugieren que la accion de la respuesta humoral depende de la victoria del antigeno sobre las barreras anatomicas. La proteccion contra infecciones en esta ave estaria vinculada con la primera linea de defensa, las mencionadas barreras, el complemento y la IgA secretoria. Estudios de epidemiologia permitirian establecer el caracter transmisor de toxoplasmosis y micoplasmosis por parte del zamuro.
Safety of Melatonin in Long-Term Use(?)

There are no published long-term safety data on the use of melatonin for whatever purpose, assuming long term to mean more than 6 months of daily medication. In the light of its physiological role in animals, the potential deleterious effects include inhibition of reproductive function, delayed timing of puberty, and influence (when taken during pregnancy and lactation) on the circadian status of the fetus and neonate and on future development. Its interactions with other medications are virtually unexplored. For most positive effects published, there also exist negative reports. There are insufficient data on its use in organic or psychiatric disease for any evaluations to be made. There are insufficient data on dose, formulation, and consequent relationships of individual pharmacokinetics and pharmacodynamics for recommendations at present. However, in normal healthy adults over 18 years old, not pregnant or lactating, with no personal or family histories of psychiatric disorder, and unmedicated except for oral contraceptives and minor analgesics (if necessary), the only significant short-term side effect in the author's experience has been sleepiness following oral ingestion of synthetic melatonin (5 mg or less, oral fast release), licensed for human experimental use and for prescription on a named-patient basis.