Miracle-dz/UniFAR-FTUs huggingface dataset:
Bar velocities capable of optimising the muscle power in strength-power exercises

ABSTRACT This study aimed at testing whether there are mean propulsive velocities (MPVs) capable of maximising the mean propulsive power (MPP) during the execution of bench press (BP), bench throw (BT), half squat (HS) and jump squat (JS). Additionally, we assessed the differences in MPP/MPV between ballistic and traditional exercises. Seventeen male rugby sevens players performed MPP tests in BP, BT, HS and JS and maximum isometric force (MIF) tests in HS and BP. The JS presented higher MPP (977.4 ± 156.2 W) than the HS (897.9 ± 157.7 W) (P < 0.05); the BP (743.4 ± 100.1 W) presented higher MPP than the BT (697.8 ± 70.4 W) (P < 0.05). Ballistic exercises presented higher optimum MPV (JS = 1.02 ± 0.07 m·s−1; BT = 1.67 ± 0.15 m·s−1) than traditional exercises (HS = 0.93 ± 0.08 m·s−1; BP = 1.40 ± 0.13 m·s−1) (P < 0.05). The optimum MPP in the JS, BT, HS and BP occurred at 28.2 ± 5.79, 23.3 ± 4.24, 32.4 ± 9.46 and 27.7 ± 5.33% of the MIF, respectively. The coefficient of variation (CV) of MPV at optimum MPP ranged from 7.4% to 9.7%, while the CV of %MIF ranged from 18.2% to 29.2%. The MPV is a more precise indicator of the optimum loads than the percentages of MIF due to its low inter-subject variability as expressed by CV. Therefore, MPV can be used to determine the optimum power load in the four investigated exercises.
Impact of Bariatric Surgery on Health Care Utilization and Costs Among Patients With Diabetes

Background:The effect of bariatric surgery on health care utilization and costs among individuals with type 2 diabetes remains unclear. Objective:To examine health care utilization and costs in an insured cohort of individuals with type 2 diabetes after bariatric surgery. Research Design:Cohort study derived from administrative data from 2002 to 2008 from 7 Blue Cross Blue Shield Plans. Participants:Seven thousand eight hundred six individuals with type 2 diabetes who had bariatric surgery. Measures:Cost (inpatient, outpatient, pharmacy, and others) and utilization (number of inpatient days, outpatient visits, specialist visits). Results:Compared with presurgical costs, the ratio of hospital costs (excluding the initial surgery), among beneficiaries who had any hospital costs, was higher in years 2 through 6 of the postsurgery period and increased over time [post 1: odds ratio (OR)=0.58; 95% confidence interval (CI), 0.50–0.67; post 6: OR=3.43; 95% CI, 2.60–4.53]. In comparison with the presurgical period, the odds of having any health care costs was lower in the postsurgery period and remained relatively flat over time. Among those with hospitalizations, the adjusted ratio of inpatient days was higher after surgery (post 1: OR=1.05; 95% CI, 0.94–1.16; post 6: OR=2.77; 95% CI, 1.57–4.90). Among those with primary care visits, the adjusted OR was lower after surgery (post 1: OR=0.80; 95% CI, 0.78–0.82; post 6: OR=0.66; 95% CI, 0.57–0.76). Conclusions:In the 6 years after surgery, individuals with type 2 diabetes did not have lower health care costs than before surgery.
Ultrawideband EH shaped stack patch antenna for wireless communications

A broadband folded patch feed antenna for ultrawideband (UWB) application is proposed and designed. The antenna consists of a folded patch feed and a shorting wall attached to E and H shaped stack patch. Bandwidth broadening is achieved by an H shaped patch fed by a folded patch feed and the size reduction is realized through the use of shorting wall. Electromagnetic coupling in between E and H shaped stack patch further enhance the impedance bandwidth in this design. The proposed antenna has a small electrical size of 19 × 15 × 10 mm3 and an impedance bandwidth of 102.36% ranging from 3.42 to 10.59 GHz. Relatively stable radiation patterns with gain greater than 4.5 dBi is obtained over the entire bandwidth.
T‐wave response in cervical root lesions

ABSTRACT T‐wave responses of biceps and triceps brachii muscles were recorded electrophysiologically from 31 normal subjects and 15 patients with unilateral lesions of the cervical C6 or C7 roots. Pathological T‐wave responses were found in 11 (73%) patients. Patients with radiological correlate showed electromyographic (EMG) pathology in 60% but a pathological T‐wave response in 90%. All patients with radiological correlate also showed pathological electrophysiological tests (EMG or T‐wave responses). Electrophysiological measurement of the T‐wave response appears to be a potentially useful tool in the diagnosis of cervical radiculopathies.
A hybrid fraud scoring and spike detection technique in streaming data

The aim has been to propose a fraud detection system with capabilities of minimizing false alarms. In this paper we introduce a technique, which uses a hybrid fraud scoring and spike detection technique in streaming data over time and space. The technique itself differentiates normal, fraud and anomalous links, and increases the suspicion of fraud links with a dynamic global black list. Also, it mitigates the suspicion of normal links with a dynamic global white list. In addition, this technique uses spike detection technique to highlight the sudden and sharp rises in data, which can be indicative of abuse. The purpose is to derive two accurate suspicion scores for all incoming new examples in real-time. Results on mining several thousand credit application data demonstrate that the proposed technique reduces false alarm rates while maintaining a reasonable hit rate. In addition, new insights have been observed from the relationships between examples. The proposed technique takes the advantages of anomaly detection and supervised techniques. However by employing the spike detection technique, the false alarm rate is decreased. By this novel integration of techniques, the proposed technique is able to foil fraudsters' attempts, which continuously morph their styles to avoid to be detected. The results of the experiments to demonstrate the benefits of the technique are also presented in this paper.
Constraints on shear wave attenuation in the Earth's inner core from an observation of PKJKP

Based on the high quality broadband data from Gräfenberg array in Germany, we recently detected a reliable PKJKP phase, for which four kinds of evidence (travel time, slowness, back‐azimuth, and comparison with a pseudo‐liquid inner core model) were simultaneously provided. Also, for the first time, a clear waveform of PKJKP was observed. This gives us an unprecedented opportunity to put constraints on the shear wave attenuation in the earth's inner core using body waves. In order to minimize the potential influence of dispersion and phase shift caused by mantle heterogeneity, we adopt an envelope modeling approach. Our results show that the estimated Qβ from the shear phase PKJKP is significantly larger (∼315 ± 150) than that from normal mode observations. Because PKJKP samples the deep inner core, this indicates an increase of Qβ with depth in the inner core, in agreement with what is generally observed for Qα.
Molecular Cancer Therapeutics BNC 105 : A Novel Tubulin Polymerization Inhibitor That Selectively Disrupts Tumor Vasculature and Displays Single-Agent Antitumor Efficacy

Dow Vascular disruption agents (VDA) cause occlusion of tumor vasculature, resulting in hypoxia-driven tumor cell necrosis. Tumor vascular disruption is a therapeutic strategy of great potential; however, VDAs currently under development display a narrow therapeutic margin, with cardiovascular toxicity posing a dose-limiting obstacle. Discovery of new VDAs, which display a wider therapeutic margin, may allow attainment of improved clinical outcomes. To identify such compounds, we used an in vitro selectivity screening approach that exploits the fact that tumor endothelial cells are in a constant state of activation and angiogenesis and do not undergo senescence. Our effort yielded the compound BNC105. This compound acts as a tubulin polymerization inhibitor and displays 80-fold higher potency against endothelial cells that are actively proliferating or are engaged in the formation of in vitro capillaries compared with nonproliferating endothelial cells or endothelium found in stable capillaries. This selectivity was not observed with CA4, a VDA currently under evaluation in phase III clinical trials. BNC105 is more potent and offers a wider therapeutic window. CA4 produces 90% vascular disruption at its no observed adverse event level (NOAEL), whereas BNC105 causes 95% vascular disruption at 1/8th of its NOAEL. Tissue distribution analysis of BNC105 in tumor-bearing mice showed that while the drug is cleared from all tissues 24 hours after administration, it is still present at high concentrations within the solid tumor mass. Furthermore, BNC105 treatment causes tumor regressions with complete tumor clearance in 20% of treated animals. Mol Cancer Ther; 9(6); 1562–73. ©2010 AACR.
Problèmes d'allocation de ressources et bien-être de Nash. Résolution par négociation entre agents

RÉSUMÉ. Allouer m ressources entre n agents, de façon à optimiser leur bien-être, est un problème qui peut souvent être résolu de manière centralisée. Cependant, pour certaines fonctions de bien-être social, une résolution centralisée n’est pas envisageable. Par exemple, le bien-être de Nash est une fonction qui a d’indéniables qualités mais qui ne peut être optimisée de manière classique. De plus, de nombreuses applications reposent sur des hypothèses qui ne peuvent pas être prises en compte par ces techniques centralisées alors que d’autres méthodes le permettent, comme les approches multi-agents. Après une présentation du problème multi-agents d’allocation de ressources, nous mettons en évidence les difficultés liées aux techniques centralisées et distribuées existantes. Nous proposons une méthode s’appuyant sur la notion de transaction sociale que nous revendiquons être la seule méthode « anytime » capable de résoudre efficacement le problème d’allocation de Nash.
Examining the role of working memory resources in following spoken instructions

ABSTRACT This study investigated the involvement of working memory (WM) in following spoken instructions using concurrent tasks designed to disrupt components of the Baddeley and Hitch WM model [Baddeley, A. D. , & Hitch, G. J. (1974). Working memory. In G. H. Bower (Ed.), The psychology of learning and motivation: Advances in research and theory (Vol. 8, pp. 47–89). New York, NY: Academic Press]. In each of three experiments, participants were presented with sequences of instructions to be either verbally repeated or physically performed using relevant objects. Backward counting, articulatory suppression, and eye closure during instruction encoding all disrupted recall, and also impaired recall of the linkage between movements and objects. Recall of actions was more accurate when they were physically enacted than repeated verbally, an advantage that was not affected by concurrent tasks. These findings indicate that aspects of the recall of spoken instructions including the binding of constituent movements to objects draw on multiple WM resources. The benefits of physical enactment of the instructed sequence do not appear to depend on the components of WM investigated in these studies.
Inhaled iloprost for sarcoidosis associated pulmonary hypertension.

RATIONALE Patients with sarcoidosis associated pulmonary hypertension (SAPH) have responded to systemic prostacyclin therapy. OBJECTIVES To determine the rate of response to inhaled prostacyclin, iloprost, in SAPH. METHODS Sarcoidosis patients with pulmonary hypertension and no evidence for left ventricular dysfunction were enrolled in an open label, prospective study. Patients underwent right heart catheterization and six minute walk (6MW) test. Quality of life was evaluated using several instruments, including the Saint George Respiratory Questionnaire (SGRQ). Patients received 5 mcg of inhaled iloprost every 2-3 hours while awake. After four months of therapy, patients underwent repeat cardiac catheterization, 6 MW test, and completed quality of life questionnaires. MEASUREMENTS AND MAIN RESULTS Of the 22 patients enrolled, 15 completed all 16 weeks of therapy. The most common reasons for study discontinuation included drug associated cough (3 patients) and compliance with the prescribed number of treatments per day (2 patients). Six patients experienced a 20% or greater decrease in pulmonary vascular resistance (PVR) from baseline with five of these six patients also showing > or = 5 mm Hg reduction in PA mean. Although three patients improved the 6MW distance by at least 30 meters, only one had a decrease in PVR. At 16 weeks a significant decrease was reported in the SGRQ activity score (p = 0.0273), with seven patients having a 4 point or greater decrease. CONCLUSION Inhaled iloprost as monotherapy was associated with an improvement in pulmonary hemodynamics and quality of life as assessed by the SGRQ activity score in some sarcoidosis patients with SAPH.
Connected vehicles - Advancements in vehicular technologies and informatics

Vehicles are becoming increasingly more sophisticated and the technology being developed in them covers a number of areas. At the heart of these developments are often the communication, information and control systems. This is very much illustrated in this "Special Section on Connected Vehicles - Advancements in Vehicular Technologies and Informatics" of the IEEE Transactions on Industrial Electronics that we are pleased to present. The Special Section contains twelve papers related to automotive technology. Obviously there a range of areas covered from very high speed machines, that could be used for cooling fans in automotive fuel cells or scaled up for drive motors, to energy management and into various communications aspects of vehicular technology.
Impact of peginterferon alpha and ribavirin treatment on lipid profiles and insulin resistance in Hepatitis C virus/HIV-coinfected persons: the AIDS Clinical Trials Group A5178 Study.

BACKGROUND The effect of peginterferon alpha/ribavirin (PEG-IFN/RBV) and hepatitis C virus (HCV) clearance on lipid and insulin resistance (IR) profiles in HCV/human immunodeficiency virus (HIV) coinfection is unknown. METHODS We measured fasting total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoproteins (HDL-C), triglycerides (TG), glucose, and insulin at defined intervals in the A5178 study (N = 329), a prospective treatment trial in HCV/HIV coinfection. Changes from baseline and the relation between baseline values of these variables to sustained virologic response (SVR) were determined. RESULTS Of 182 subjects with metabolic data, 98 achieved early virologic response (EVR) and continued PEG-IFN/RBV. Among those, median pretreatment HCV RNA was 6.6 log(10 )IU/mL; 73% had HCV genotype 1. Median pretreatment TC was 176 mg/dL (interquartile range [IQR],150-205]; median LDL-C was 99 mg/dL (IQR, 79-123); median HDL-C was 40 mg/dL (IQR, 31-47); and median TG was 147 mg/dL (IQR, 101-221). Median homeostasis model assessment of IR (HOMA-IR) was 3.3 (IQR, 1.7-5.3). The EVRs demonstrated a decline in TC, LDL-C, and HDL-C, whereas TG increased on treatment but returned to near baseline 24 weeks after end of treatment (EOT). The HOMA-IR decline from entry to 24 weeks after EOT was significant among non-sustained virologic responders and nonsignificant among sustained virologic responders; this difference was offset after adjusting for higher HOMA-IR at baseline among the former. Among all 182 subjects, entry LDL-C was associated with SVR in a joint logistic model adjusted for HCV genotype, race, and prior IFN (odds ratio, 1.17 per 10 mg/dL increase; 95% confidence interval, 1.03-1.32), but TC, HDL, TG, and IR were not. CONCLUSIONS Peginterferon alpha and RBV can significantly affect lipid profile and IR in HCV/HIV-coinfected persons. Although the lipid profile returns to near pretreatment levels after completion of treatment, our data suggest persistent modest improvement in IR with treatment. Clinical Trials Registration. NCT00078403.
BMI and Magnitude of Scoliosis at Presentation to a Specialty Clinic

OBJECTIVE: To determine whether curve magnitude of scoliosis at presentation correlates with BMI. METHODS: Retrospective chart review of 180 patients presenting with scoliosis was performed. Curve pattern and magnitude, Risser status, occurrence of surgery, zip code, height and weight, race, and insurance status were recorded. Relationships were examined by Spearman rank and Pearson correlations, and logistic regression analysis was used to determine odds ratios. RESULTS: For both thoracic and lumbar curve patterns, there was a correlation between BMI and curve magnitude. Spearman rank correlation was 0.19 for thoracic (P = .03) and 0.24 for lumbar curves (P = .02). Overweight or obese patients were not more likely, however, to present with curves at higher risk of progression or more likely to have surgical intervention. With respect to potential confounding socioeconomic variables, thoracic curve magnitude was negatively correlated with median family income (Spearman rank correlation –0.17, P = .04). Curve magnitude was not correlated with race, distance, or insurance payer. CONCLUSIONS: Patients with high BMI and scoliosis are more likely to present with larger curves, but not more likely to require surgery. This is concerning because of the national trend of increasing childhood obesity and because scoliosis treatment may be more complicated in larger curves. Socioeconomic factors may also be barriers to access.
Improved Kernel Security Thr ough Code Validation, Diversific ation, and Minimization

The vast majority of hosts on the Internet, including mobile clients, are running one of three commodity, general-purpose operating system families. In such operating systems the kernel software executes at the highest processor privilege level. If an adversary is able to hijack the kernel software then by extension he has full control of the system. This control includes the ability to disable protection mechanisms and hide evidence of compromise. The lack of diversity in commodity, general-purpose operating systems enables attackers to craft a single kernel exploit that has the potential to infect millions of hosts. If enough variants of the vulnerable software exist, then mass exploitation is much more difficult to achieve. We introduce novel kernel diversification techniques to improve kernel security. Many modern kernels are self-patching; they modify themselves at run-time. Self-patching kernels must therefore allow kernel code to be modified at run-time. To prevent code injection attacks, some operating systems and security mechanisms enforce a W^X memory protection policy for kernel code. This protection policy preventsself-patching kernels from applying patches at run-time. We introduce a novel run-time kernel instruction-level validation technique to validate the integrity of patches at run-time. Kernels shipped with general-purpose operating systems often contain extraneous code. The code may contain exploitable vulnerabilities or may be pieced together using return/jump-oriented programming to attack the system. Code-injection prevention techniques do not prevent such attacks. We introduce a novel run-time kernel minimization technique to improve kernel security. We show that it is possible to strengthen the defenses of commodity general-purpose computer operating systems by increasing the diversity of, validating the integrity of, and ensuring the minimality of the included kernel components without modifying the kernel source code. Such protections can therefore be added to existing widely-used unmodified operating systems to prevent malicious software from executing in supervisor mode.
Cardiovascular disease risk factors in chronic kidney disease: overall burden and rates of treatment and control.

BACKGROUND Mild to moderate chronic kidney disease (CKD) is associated with increased risk for cardiovascular disease. The burden of cardiovascular disease risk factors in this setting is not well described. METHODS We compared the age- and sex-adjusted prevalence of cardiovascular disease risk factors and their treatment and control among persons with and without CKD in 3258 Framingham offspring cohort members who attended the seventh examination cycle (1998-2001). Glomerular filtration rate (GFR) was estimated using the simplified Modification of Diet in Renal Disease Study equation. We defined CKD as a GFR of less than 59 mL/min per 1.73 m(2) in women and less than 64 mL/min per 1.73 m(2) in men. RESULTS Those with CKD were older, more likely to be obese (33.5% vs 29.3%; P=.02), and more likely to have low levels of high-density lipoprotein cholesterol (45.2% vs 29.4%; P<.001) and high triglyceride levels (39.9% vs 29.8%; P<.001). Those with CKD had a higher prevalence of hypertension (71.2% vs 42.7%; P<.001) and hypertension treatment (86.0% vs 72.5%; P<.001), but were less likely to achieve optimal blood pressure control (27.0% vs 45.5%; P<.001). Participants with CKD had a higher prevalence of elevated low-density lipoprotein cholesterol levels (60.5% vs 44.7%; P=.06) and lipid-lowering therapy (57.1% vs 42.6%; P=.09), although this was not statistically significant. A greater proportion of individuals with CKD than those without had diabetes (23.5% vs 11.9%; P=.02) and were receiving diabetes treatment (63.6% vs 46.9%; P=.05), but were less likely to achieve a hemoglobin A(1c) level of less than 7% (43.8% vs 59.4%; P=.03). CONCLUSIONS Chronic kidney disease is associated with a significant burden of cardiovascular disease risk factors in the community. The diagnosis of CKD should alert the practitioner to look for potentially modifiable cardiovascular risk factors.