Miracle-dz/UniFAR-FTUs huggingface dataset:
Contribution à la commande décentralisée non-linéaire des réseaux électriques

Aujourd'hui, les grands reseaux electriques fonctionnent de plus en plus pres de leur limite de stabilite. Les moyens de controle classique des reseaux permettent d'assurer leur stabilite dans des conditions de fonctionnement normales. Cependant, compte tenu de la variete des conditions et des schemas d'exploitation, de la severite des incidents, les equipements de commande actuellement installes surles reseaux peuvent s'averer trop limites et insuffisants pour repondre efficacement aux diverses perturbations. L'objectif general de cette these est l'etude et la comparaison de methodologies de synthese de controleurs decentralises non lineaires qui puissent ameliorer la stabilite transitoire des reseaux electriques. La notion de controleur decentralise signifie ici que les grandeurs necessaires pour elaborer la commande sont disponibles localement, c'est-a-dire a proximite du turbo-generateur a controler.Dans une premiere etape, nous nous sommes fixes l'objectif de developper une methodologie de commande non-lineaire qui puisse ameliorer les amortissements des oscillations transitoires provenant des courts-circuits triphases se presentant sur la ligne de transmission, dans le contexte d'un systeme SMIB (une seule machine connectee a un n\oe ud infini). Dans une deuxieme etape, nous nous sommes donnes l'objectif de generaliser cette methodologie de commande non lineaire a un reseau multi-machines interconnecte. Nous nous sommes aussi fixes comme objectif dans ce cadre de tester la demarche proposee pour controler l'amortissement des oscillations basse frequence (0.1-10 (dollar) HZ (dollard) locales et inter-zones.
The domains of slow bacterial growth.

Commonly used culture systems, e.g., batch culture and the chemostat, work poorly for defining the behavior of slowly growing bacteria, i.e., cultures with mass doubling times, tD, longer than 10-12 h. This has slowed the process of understanding how bacteria behave at the longer tD's that embrace most of their existence. Culture systems are identified that give useful access to these longer doubling times. When these slow-growth systems are used with nutrient-limited populations, it is found that cellular concentrations of guanosine 5'-diphosphate 3'-diphosphate, the main effector of the stringent response, commence rising above basal levels at tD's longer than 12 h until, at a tD of 60-70 h, the level is reached that causes the interdiction of protein and ribosome synthesis characteristic of the response. The abrupt onset of the stringent response in eubacteria at a particular tD, corresponding to a specific rate of nutrient uptake, makes oft-used growth equations that do not account for this onset, e.g., those of Monod or Pirt, poor descriptors of slow growth. A serious imbalance between lateral and transverse wall formation rates which, unless corrected, would lead to abnormal cell division can be inferred to develop at tD's longer than 10-12 h. The necessary correction may be supplied by the effects of increased levels of guanosine 5'-diphosphate 3'-diphosphate on transverse wall synthesis.
Spatial and temporal variations of MIMO channels and impacts on capacity

This paper presents analysis for spatial and temporal variations of multiple-input-multiple-output (MIMO) channels at the mobile. The channel study is based on the narrowband measurements at 2.11 GHz in Manhattan, New York with 16 transmitting antennas and 16 receiving antennas. Doppler spread and angle of arrival (AOA) are derived from the temporal correlation of field components. The results show that the AOA at the mobile is not uniformly distributed. The restricted AOA distribution results in approximately twice the correlation distance and correlation time than the predicted values from the Jakes (1974) model. The measured median coherence time is at least a few seconds for stationary channels, and 90 ms at a mobile pedestrian speed of 3 km/hr. These observations hold for both vertically and horizontally polarized antennas. The measured median RMS angular spread at the mobile is 22.5/spl deg/ for horizontally polarized antennas and 25.5/spl deg/ for vertically polarized antennas.
The Study of Consumer Trust Transference for the Adoption of Mobile Service

Mobile commerce becomes increasingly popular in China. The applications of mobile commerce are rich. Especially, mobile brokerage service is an emerging application of mobile commerce in the brokerage industry. Although mobile brokerage service has many advantages, the number of investors using the MBS to conduct stock trading is far smaller than those using other trading methods. Lack of trust is a big obstacle for investors to adopt mobile brokerage service. Most studies only consider the impact factors of trust in one environment and rare research explores trust building by trust transference across different environment. Based on mobile brokerage service, we build a model of trust transference from online to mobile setting and empirically test it. The results indicate trust in the online brokerage service of a brokerage firm influences cognitive beliefs about the firm's mobile brokerage service. Keywords-mobile commerce;mobile brokerage service; trust; trust transfer
A Compact Model of the Pinch-off Region of 100 nm MOSFETs Based on the Surface-Potential

We have developed a model for circuit-simulation which describes the MOSFET region from pinch-off to drain contact based on the surface potential. The model relates the surface-potential increase beyond the pinch-off point to the channel/drain junction profile by applying the Gauss law with the assumption that the lateral field is greater than the vertical one. Explicit equations for the lateral field and the pinch-off length are obtained, which take the potential increase in the drain overlap region into account. The model, as implemented into a circuit simulator, correctly reproduces measured channel conductance and overlap capacitance for 100 nm pocket-implant technologies as a function of bias condition and gate length.
Occurrence and prognosis of extranodal lymphomas

A series of 1,467 Caucasian patients with non‐disseminated lymphomas of extranodal origin was taken from data collected by the End Results Group of cancer registries in the years 1950‐1964. Excluding Hodgkin's disease, about one fourth of the lymphomas reported arose in sites other than lymph nodes. Survival rates and distributions are listed for site of origin, major histologic types, sex, age, and extent of disease. For the more frequently reported sites, survival rates are given according to the type of initial treatment used. The prognosis of patients with extranodal lymphomas is compared with that for “all cancers” of the same site, and the lymphoma patients appear to fare appreciably better when the site of origin is stomach, lung, or tonsil.
High Level of Legumain Was Correlated With Worse Prognosis and Peritoneal Metastasis in Gastric Cancer Patients

Background: Accumulating evidence has demonstrated that legumain (LGMN) is abnormally expressed in several malignancies and functions as an oncogene. However, the association between LGMN and gastric cancer (GC) has not yet been fully elucidated. In this study, we performed a comprehensive analysis of the role of LGMN in clinicopathologic characteristics and survival of GC patients. Methods: The study had two patient cohorts, The Cancer Genome Atlas (TCGA) cohort and the Zhongshan Hospital cohort, both of which were used to analyze the role of LGMN in GC samples. The relationship between LGMN and clinicopathologic characteristics was determined by the Chi-square test and logistic regression analysis. The Kaplan–Meier method and Cox proportional hazards regression analysis were conducted to investigate the prognostic role of LGMN in GC patients. Moreover, a nomogram was constructed based on the factors that were independently associated with peritoneal metastasis. Finally, the gene set enrichment analysis (GSEA) was conducted to explore the underlying pathways through which LGMN was involved in GC progression. Results: The mRNA and protein levels of LGMN were significantly upregulated in GC tissues, especially for diffuse-type GC. High level of LGMN was independently associated with poor prognosis in both TCGA and Zhongshan cohorts. Further analysis showed that increased protein level of LGMN was related to peritoneal metastasis in GC patients. In a nomogram model, the LGMN expression could help predict the possibility of peritoneal metastasis in GC patients. LGMN was a strong determinant for prediction of peritoneal metastasis. GC patients with high LGMN expression tended to have worse survival together with more frequent diffuse-type tumors and increased risk of peritoneal metastasis. The GSEA results showed that focal adhesion, ecm receptor interaction, cell adhesion molecules cams, TGF-β signaling pathway, JAK-STAT signaling pathway, gap junction, etc. were differentially enriched in the phenotype with high LGMN expression. Conclusion: LGMN was an independent prognostic factor for OS in GC patients. Increased expression of LGMN was significantly associated with peritoneal metastasis. The nomogram based on LGMN might guide the clinical decisions for patients with GC.
Novel Toxin-Antitoxin System Composed of Serine Protease and AAA-ATPase Homologues Determines the High Level of Stability and Incompatibility of the Tumor-Inducing Plasmid pTiC58

ABSTRACT Stability of plant tumor-inducing (Ti) plasmids differs among strains. A high level of stability prevents basic and applied studies including the development of useful strains. The nopaline type Ti plasmid pTiC58 significantly reduces the transconjugant efficiency for incoming incompatible plasmids relative to the other type, such as octopine-type plasmids. In this study we identified a region that increases the incompatibility and stability of the plasmid. This region was located on a 4.3-kbp segment about 38 kbp downstream of the replication locus, repABC. We named two open reading frames in the segment, ietA and ietS, both of which were essential for the high level of incompatibility and stability. Plasmid stabilization by ietAS was accomplished by a toxin-antitoxin (TA) mechanism, where IetS is the toxin and IetA is the antitoxin. A database search revealed that putative IetA and IetS proteins are highly similar to AAA-ATPases and subtilisin-like serine proteases, respectively. Amino acid substitution experiments in each of the highly conserved characteristic residues, in both putative enzymes, suggested that the protease activity is essential and that ATP binding activity is important for the operation of the TA system. The ietAS-containing repABC plasmids expelled Ti plasmids even in strains which were tolerant to conventional Ti-curing treatments.
Rice ETHYLENE RESPONSE FACTOR 101 Promotes Leaf Senescence Through Jasmonic Acid-Mediated Regulation of OsNAP and OsMYC2

Leaf senescence is the final stage of leaf development and an important step that relocates nutrients for grain filling in cereal crops. Senescence occurs in an age-dependent manner and under unfavorable environmental conditions such as deep shade, water deficit, and high salinity stresses. Although many transcription factors that modulate leaf senescence have been identified, the mechanisms that regulate leaf senescence in response to environmental conditions remain elusive. Here, we show that rice (Oryza sativa) ETHYLENE RESPONSE FACTOR 101 (OsERF101) promotes the onset and progression of leaf senescence. OsERF101 encodes a predicted transcription factor and OsERF101 transcript levels rapidly increased in rice leaves during dark-induced senescence (DIS), indicating that OsERF101 is a senescence-associated transcription factor. Compared with wild type, the oserf101 T-DNA knockout mutant showed delayed leaf yellowing and higher chlorophyll contents during DIS and natural senescence. Consistent with its delayed-yellowing phenotype, the oserf101 mutant exhibited downregulation of genes involved in chlorophyll degradation, including rice NAM, ATAF1/2, and CUC2 (OsNAP), STAY-GREEN (SGR), NON-YELLOW COLORING 1 (NYC1), and NYC3 during DIS. After methyl jasmonate treatment to induce rapid leaf de-greening, the oserf101 leaves retained more chlorophyll compared with wild type, indicating that OsERF101 is involved in promoting jasmonic acid (JA)-induced leaf senescence. Consistent with the involvement of JA, the expression of the JA signaling genes OsMYC2/JA INSENSITIVE 1 (OsJAI1) and CORONATINE INSENSITIVE 1a (OsCOI1a), was downregulated in the oserf101 leaves during DIS. Transient transactivation and chromatin immunoprecipitation assays revealed that OsERF101 directly binds to the promoter regions of OsNAP and OsMYC2, which activate genes involved in chlorophyll degradation and JA signaling-mediated leaf senescence. These results demonstrate that OsERF101 promotes the onset and progression of leaf senescence through a JA-mediated signaling pathway.
Functional and pharmacological consequences of the distribution of voltage‐gated calcium channels inthe renal blood vessels

Calcium channel blockers are widely used to treat hypertension because they inhibit voltage‐gated calcium channels that mediate transmembrane calcium influx in, for example, vascular smooth muscle and cardiomyocytes. The calcium channel family consists of several subfamilies, of which the L‐type is usually associated with vascular contractility. However, the L‐, T‐ and P‐/Q‐types of calcium channels are present in the renal vasculature and are differentially involved in controlling vascular contractility, thereby contributing to regulation of kidney function and blood pressure. In the preglomerular vascular bed, all the three channel families are present. However, the T‐type channel is the only channel in cortical efferent arterioles which is in contrast to the juxtamedullary efferent arteriole, and that leads to diverse functional effects of L‐ and T‐type channel inhibition. Furthermore, by different mechanisms, T‐type channels may contribute to both constriction and dilation of the arterioles. Finally, P‐/Q‐type channels are involved in the regulation of human intrarenal arterial contractility. The calcium blockers used in the clinic affect not only L‐type but also P‐/Q‐ and T‐type channels. Therefore, the distinct effect obtained by inhibiting a given subtype or set of channels under experimental settings should be considered when choosing a calcium blocker for treatment. T‐type channels seem to be crucial for regulating the GFR and the filtration fraction. Use of blockers is expected to lead to preferential efferent vasodilation, reduction of glomerular pressure and proteinuria. Therefore, renovascular T‐type channels might provide novel therapeutic targets, and may have superior renoprotective effects compared to conventional calcium blockers.
Hypervolume based metaheuristics for multiobjective optimization

The purpose of multiobjective optimization is to find solutions that are optimal regarding several goals. In the branch of vector or Pareto optimization all these goals are considered to be of equal importance, so that compromise solutions that cannot be improved regarding one goal without deteriorating in another are Paretooptimal. A variety of quality measures exist to evaluate approximations of the Paretooptimal set generated by optimizers, wherein the hypervolume is the most significant one, making the hypervolume calculation a core problem of multiobjective optimization. This thesis tackles that challenge by providing a new hypervolume algorithm from computational geometry and analyzing the problem’s computational complexity. Evolutionary multiobjective optimization algorithms (EMOA) are state-of-the-art methods for Pareto optimization, wherein the hypervolume-based algorithms belong to the most powerful ones, among them the popular SMS-EMOA. After its promising capabilities have already been demonstrated in first studies, this thesis is dedicated to deeper understand the underlying optimization process of the SMS-EMOA and similar algorithms, in order to specify their performance characteristics. Theoretical analyses are accomplished as far as possible with established and newly developed tools. Beyond the limitations of rigorous scrutiny, insights are gained via thorough experimental investigation. All considered problems are continuous, whereas the algorithms are as well applicable to discrete problems. More precisely, the following topics are concerned. The process of approaching the Pareto-optimal set of points is characterized by the convergence speed, which is analyzed for a general framework of EA with hypervolume selection on several classes of bi-objective problems. The results are achieved by a newly developed concept of linking single and multiobjective optimization. The optimization on the Pareto front, that is turning the population into a set with maximal hypervolume, is considered separately, focusing on the question under which circumstances the steady-state selection of exchanging only one population member suffices to reach a global optimum. We answer this question for different bi-objective problem classes. In a benchmarking on so-called many-objective problems of more than three objectives, the qualification of the SMS-EMOA is demonstrated in comparison to other EMOA, while also studying their cause of failure. Within the mentioned examinations, the choice of the hypervolume’s reference point receives special consideration by exposing its influence. Beyond the study of the SMS-EMOA with default setup, it is analyzed to what extent the performance can be improved by parameter tuning of the EMOA anent to certain problems, focusing on the influence of variation operators. Lastly, an optimization algorithm based on the gradient of the hypervolume is developed and hybridized with the SMS-EMOA.
Modélisation homotopique et segmentation tridimensionnelles du cortex cérébral à partir d'irm pour la résolution des problèmes directs et inverses en eeg et en meg

L'objectif de cette these est de fournir une contribution aux etudes anatomiques et fonctionnelles du cerveau en proposant une methode de modelisation et de segmentation du cortex en IRM qui soit adaptee aux utilisations en electroencephalographie (EEG) et en magnetoencephalographie (Meg). Dans la premiere partie de ce travail, nous abordons rapidement les differentes modalites d'imagerie fonctionnelle cerebrale et montrons l'importance que revet la modelisation de l'anatomie corticale pour l'analyse des donnees fonctionnelles, en particulier pour la Meg et l’EEG. Ensuite, nous faisons le point sur les differentes methodes permettant d'extraire l'anatomie corticale a partir d'une image IRM. Nous montrons que la prise en compte de la geometrie et de la topologie des sillons ne peut se faire qu'en developpant d'une modelisation appropriee. La seconde partie de ce rapport presente un modele cellulaire permettant d'accroitre les possibilites de modelisation des images classiques en permettant notamment de representer, sans apparition de paradoxe topologique, des scenes constituees de plusieurs objets ayant differentes dimensions locales. Nous introduisons ensuite une caracterisation originale des deformations homotopiques d'un objet discret s'appuyant sur son graphe de voisinage. Nous utilisons ces resultats pour caracteriser localement les deformations homotopiques elementaires d'une scene representee par un modele cellulaire. Enfin nous presentons un cadre informatique permettant de representer et d'utiliser un modele cellulaire homotopiquement deformable. La derniere partie de ce manuscrit presente une methode de segmentation de la surface corticale s'appuyant sur les deformations homotopiques d'un modele cellulaire. Le modele est initialise a partir d'une segmentation du cerveau lisse puis deforme homotopiquement vers l'interieur des sillons, la modelisation cellulaire permettant au modele de s'adapter a la geometrie profonde des sillons corticaux.
New insights on multiphase synchronous buck converter design: A comprehensive consideration

This paper comprehensively discusses the multiphase power converter design and introduces new control schemes in dynamic operations, which are now used to supply the power for modern Multi-Core processor (MCP) and multiprocessor System-on-Chip (MPSoC). With the aggressive motivation to boost dynamic power efficiency, the design specification of the VR is pushing the physical limitation of the multiphase converter design and the component stress as well. In this paper, the operation modes and PWM drive interface to achieve phase shedding are first illustrated. Robust driver operation is ensured when exiting the tri-state for long time. Nonlinear control scheme is introduce to minimize the voltage excursion during load transient. CdV/dt compensation for removing the AVP effect and novel nonlinear control scheme for smooth transition are proposed for dealing with fast voltage positioning. For experimental verification, a 400 W six phase synchronous buck converter is implemented with the proposed schemes.
Study on the optimal parameters of artificial neural networks by applying uniform design

When an artificial neural network (ANN) is used for modeling applications, the architecture and parameters of the network, like number of units and number of layers in each layer, need to be determined. In this paper, the uniform design is used to reduce the number of experiments to find the important factors, and the regression analysis methodology is then applied to find more accurate combination of design parameters for optimizing the ANN modeling.
Hydrogen Abstraction Ability of Different Aromatic Nitroxides

Indolinonic aromatic nitroxides have been shown to efficiently inhibit free radical mediated oxidation reactions in biological systems. Since all antioxidants also possess pro-oxidant activity, possibly through a hydrogen abstraction process from suitable substrates, the relative hydrogen abstraction abilities of these compounds were evaluated. Different hydrogen donors were reacted with an indolinic and two indolinonic nitroxides and the rates of hydrogen abstraction were determined using UV–Vis spectroscopy. From the data obtained, a structure–activity relationship was found. In addition, the hydrogen abstraction ability of these compounds was found to be much greater than that of the aliphatic nitroxide TEMPO, despite existing reports indicating that these two classes of compounds show similar antioxidant activities in biological systems.
Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma

Recently, an unusual subtype of large B-cell lymphoma (LBCL) with distinctive clinicopathologic features has been recognized; it is characterized by involvement of bone marrow with or without liver and/or spleen, but no lymph node or other extranodal sites, usually associated with fever, anemia, and hemophagocytic lymphohistiocytosis (HLH). Because of this distinctive clinical presentation, it has been designated “bone marrow-liver-spleen” (BLS) type of LBCL. To date there is only one series of 11 cases of BLS type of LBCL with detailed clinical, pathologic, and cytogenetic data. Herein, we describe a case of BLS type LBCL presenting with associated HLH in a 73-year-old female. The bone marrow core biopsy showed cytologically atypical large lymphoma cells present in a scattered interstitial distribution and hemophagocytosis and infrequent large lymphoma cells were seen in the bone marrow aspirate smears. Circulating lymphoma cells were not seen in the peripheral blood smears. The patient underwent treatment with chemotherapy (R-CHOP) but unfortunately passed away 2 months after initial presentation. BLS type of LBCL is a very rare and clinically aggressive lymphoma whose identification may be delayed by clinicians and hematopathologists due to its unusual clinical presentation and pathologic features.