Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical Antecedents of Neurologic and Audiologic Abnormalities in Survivors of Neonatal Extracorporeal Membrane Oxygenation

Extracorporeal membrane oxygenation is an effective rescue treatment for severe cardiorespiratory failure in term or near-term neonates, although cerebral palsy, mental retardation, and sensorineural hearing loss are observed in 10 to 20% of survivors. The objective of the present study was to identify potential risk factors that may explain the neurologic and audiologic sequelae noted in 19% of 181 survivors of neonatal extracorporeal membrane oxygenation from our hospital. Our results suggest the following findings in survivors of severe cardiorespiratory failure treated with neonatal extracorporeal membrane oxygenation: (1) hypotension or the need for cardiopulmonary resuscitation before extracorporeal membrane oxygenation significantly increases the risk of spastic cerebral palsy, (2) profound hypocarbia before extracorporeal membrane oxygenation is associated with a significantly increased risk of hearing loss, (3) mental retardation in the absence of spastic cerebral palsy is unexplained except when due to abnormal fetal brain development, and (4) hypoxemia in the absence of hypotension does not increase the risk of neurologic or audiologic sequelae. (J Child Neurol 1997;12:415-422).
Performance analysis of adaptive filters for time-varying systems

Two typical adaptive algorithms, LMS filtering and RLS filtering, were introduced and compared in this paper. The convergence performance and tracking performance in non-stationary were analyzed by simulation. When the identification plant was time-varying, adaptive filters should have the ability of tracking the minimum point. Compared with LMS filters, one important feature RLS filters have is convergence rate, but the improvement of this performance is cost by the increasing calculation complexity of RLS filters. According to simulation analysis, in time-varying environment, LMS filters have better tracking performance than RLS filters.
Outbreak of invasive meningococcal disease among soldiers in Skwierzyna, Poland, March 2006.

The outbreak Four cases of invasive meningococcal disease were reported between 22 and 24 March 2006 in newly recruited soldiers in Skwierzyna in Lubuskie, a western province of Poland. Two soldiers had been referred to a physician on 21 March with influenza-like symptoms, and one of them had consulted a physician in a local hospital, but was not admitted to hospital for treatment. On 22 March both soldiers had sudden onset of petechial rash, general discomfort and fever. They were immediately admitted to the intensive care unit of the regional hospital in Gorzow Wielkopolski. A third soldier had similar symptoms of malaise and signs of meningeal irritation on 23 March. He was admitted to the local hospital for observation, where he developed a petechial rash. A fourth soldier developed pharyngitis on 23 March, and was also admitted to the local hospital for observation, where he developed severe headache and vomiting on 24 March. Both soldiers were admitted to the intensive care unit in Gorzow Wielkopolski immediately after symptom onset. Preliminary investigation of blood and cerebrospinal fluid samples at the National Reference Centre for Bacterial Meningitis revealed that all cases were caused by Neisseria meningitidis serotype C.
D endroaspis natriuretic peptide relaxes isolated human arteries and veins

Background: Dendroaspis natriuretic peptide (DNP) is the newest member of the natriuretic peptide family and is a circulating peptide in humans. The effects of DNP on the human vasculature are unknown. Since other natriuretic peptides are known to cause vasorelaxation, we determined the response to DNP on human blood vessels in vitro. We also investigated the mechanism of DNP mediated vasorelaxation. Methods: Rings of human internal mammary artery and saphenous vein were suspended in an organ bath. The response to cumulative concentrations of DNP was obtained. Inhibiting agents were used to determine the mechanism of this vasorelaxation. Results: DNP caused dose-dependent relaxation, with a greater effect on the internal mammary arteries (relaxation from 27 27 10 mol / l DNP: 80.6 4.1%) than the saphenous veins (33.4 64.1%). At 10 mol / l, DNP resulted in less arterial relaxation compared with atrial and C-type natriuretic peptides and similar relaxation to brain natriuretic peptide. In veins, DNP caused the greatest relaxation of the natriuretic peptides. DNP increased tissue cyclic guanosine monophosphate (cGMP) determined by radioimmunoassay by over 7-fold. Barium chloride and indomethacin attenuated DNP mediated vasorelaxation. However, glibenclamide, charydotoxin, apamin, tetraethyl-ammonium chloride and diisothiocyanato-stilbene-2,2 9-disulfonic acid did not. DNP mediated vasorelaxation was mildly attenuated with removal of the endothelium. DNP immunoreactivity was identified in both arteries and veins. Conclusions: The current study demonstrates that DNP is an endogenous human natriuretic peptide that relaxes human arteries more than veins. Furthermore, DNP mediated vasorelaxation involves the inward rectifying potassium channels, prostaglandins, and cGMP. This newest member of the natriuretic peptide family may have an important physiologic role in the human vasculature.  2002 Elsevier Science B.V. All rights reserved.
Impact of Strategic Planning on Financial Performance of Companies in Turkey

Strategic planning is important for strategic management of companies. The purpose of this study is to explore the impact of strategic planning on financial performance of major industrial enterprises of Turkey. Our findings show that many domestic and foreign firms in our sample have a strategic process in place. It is an annual process and considered a very important organizational activity. This paper is one of the few studies to examine the strategic planning process in a sample of firms from a transitional economy. It can be considered a longitudinal study because it examines a set of institutions to identify changes in their performance over time, as they incorporate the use of strategic tools in a dynamic competitive environment. The findings of this study provide a contribution to our understanding of the nature and practice of strategic planning in Turkish companies and possibilities of correlations between their efforts and performance.
SGK1 Regulation of Epithelial Sodium Transport

Epithelial ion transport is regulated in vertebrates by a variety of hormonal and non-hormonal factors, including mineralocorticoids, insulin, and osmotic shock. SGK1 has been established as an important convergence point for multiple regulators of Na+transport. Unlike most serine-threonine kinases, SGK1 is under dual control: protein levels are controlled through effects on its gene transcription, while its activity is dependent on phosphatidylinositol-3-kinase (PI3K) activity. Aldosterone is the most notable regulator of SGK1 protein level in ion transporting epithelia, while insulin and other activators of the of PI3K are key regulators of its activity. Activated SGK1 regulates a variety of ion transporters, the best characterized of which is the epithelial sodium channel (ENaC). The apical targeting of ENaC is controlled by the ubiquitin ligase, Nedd4-2, and SGK1 acts, at least in part, through phosphorylation-dependent inhibition of Nedd4-2. This effect of SGK1 requires physical associations of Nedd4-2 with both SGK1 and ENaC. Moreover, direct physical association between SGK1 and ENaC may also be implicated in the formation of a tertiary complex. Osmotic shock is likely the most important non-hormonal regulator of SGK1 expression, and surprisingly, SGK1 expression can be induced by hypotonic or hypertonic stress in a cell-type dependent fashion. The SGK family represents an ancient arm of the serine-threonine kinase family, present in all eukaryotes that have been examined, including yeast. SGK1 appears to have been implicated in membrane trafficking and possibly in the control of ion transport and cell volume in early single cell eukaryotes. In metazoan epithelia, it seems likely that SGK1 was adapted to the regulation of ion transport in response to hormonal and osmotic signals.
Dad! where Are We Going？

《爸爸去哪儿》是湖南卫视的大型明星亲子生存体验真人秀，由林志颖父子、田亮父女、郭涛父子、王岳伦父女、张亮父子联手担任嘉宾。 这个节目不仅仅满足了人们了解明星生活的愿望，也让人们体验到了明星们所传达给子女们的无限的父爱，这也是人们喜欢这个节目的重要原因。
ToxR co‐operative interactions are not modulated by environmental conditions or periplasmic domain conformation

ToxR is a transmembrane regulatory protein that controls virulence gene expression in Vibrio cholerae. Previous experiments using λ repressor–ToxR chimeric proteins and a λ repressor‐controlled reporter system (OR1 PR–lacZY ) established that ToxR sequences can effectively dimerize the amino‐terminal domain of λ repressor in Escherichia coli. However, in E. coliToxR does not respond to environmental signals that control virulence gene expression in V. cholerae. Here, we report the results of experiments designed to test whether environmental signals that modulate virulence gene expression in V. cholerae also modulate a monomer to dimerization transition of λ–ToxR chimeras. When the OR1 PR–lacZY reporter fusion and chimeric proteins were transferred to V. cholerae, we unexpectedly found that λ–ToxR chimeras did not dimerize significantly. Interestingly, experiments evaluating the ability of λ–ToxR proteins to form tetramers in E. coli suggested that λ–ToxR dimers could act co‐operatively. Using a redesigned reporter system containing multiple λ operator sites (OR1 OR2 OR3 PR–lacZY ), we found that λ–ToxR could dimerize quite efficiently in V. cholerae. These data imply that multiple DNA binding sites might enhance the ability of ToxR to dimerize in V. cholerae and suggest that ToxR dimers might be capable of co‐operative interactions. However, we failed to correlate a monomer–dimer transition of the λ–ToxR chimeras with changes in virulence gene expression in response to environmental signals in V. cholerae. Finally, because of conflicting results in the literature, the importance of membrane localization of ToxR and dimerization of the ToxR periplasmic domain was re‐evaluated. This was accomplished by measuring the ability of various chimeric proteins to activate toxin gene expression in both E. coli and V. cholerae. These assays suggest that, in V. choleraedeletion of the transmembrane domain has a profound effect on ToxR activity, although it is not an absolute requirement when ToxR is dimerized by a heterologous domain. In addition, we noted differences in chimeric protein activity when expressed in E. coli and V. cholerae. A construct substituting the monomeric MalE domain for the periplasmic domain of ToxR was unable to activate a ctx::lacZ reporter fusion in E. coli. Although the addition of leucine zipper sequences to this construct resulted in enhanced activity of the chimera in E. coli, both chimeras were able to produce wild‐type levels of toxin in V. cholerae. These data support the notion that dimerization of ToxR stimulates its activity as a transcriptional activator in E. coli. In V. cholerae, however, we present data that do not demonstrate a correlation between dimerization of the periplasmic domain and ToxR activity.
Notice of RetractionUltimate ownership, investor relations management and firm value: Evidence from family listed-companies in China

This thesis analyzes the affection of ultimate ownership to IRM and firm value under family pyramid structure of China. We find that: the IRM of family listed-companies has a negative relation with control rights of family controlling, positive relation with cash flow rights, negative relation with excessive control rights and positive relation with firm value. Further more, the IRM and firm value of family listed-companies has a negative relation with whether or not controlling shareholder appoints to management layer and whether CEO unites as one or not with president.
Implementación de redes neuronales y lógica difusa para la clasificación de patrones obtenidos por un Sónar

This article describes a methodology using neural network models Adaline architecture and linguistically interpretable fuzzy systems, both algorithms were used to classify data signal rocks and metals, obtained through sonar. First, the neural network requires training match each input vector with the corresponding output vector for comparison with the desired output, and obtained, through feedback differential, an algorithm that minimizes the error. Secondly, the diffuse pattern contains overlapping of triangular sets to adjust the number of data sets for the antecedent, and singletons for to the consequent. In the evaluation of the rules are used instead of operators average T-norm and the consequents are adjust using recursive least squares. The promising aspect of this research was to achieve a good accuracy in the validation, after training of neural networks, and apply the fuzzy model without sacrificing the fuzzy system interpretability. Both methods are used making little modifications of parameters for obtain the best success percentage, the lowest mean square error (MSE), decreasing execution time, reducing effort in the processing machine and without recourse to other artificial intelligence techniques.
Fouille de grands ensembles de données avec un boosting de Proximal SVM

Résumé. Les SVM (support vector machines) ont montré leur efficacité dans plusieurs domaines d'application. L’apprentissage des SVM se ramène à résoudre un programme quadratique, dont la mise en œuvre est en général coûteuse en temps. Une reformulation plus récente des SVM (proximal SVM), proposée par Fung et Mangasarian, ne nécessite que la résolution d’un système linéaire, cet algorithme de PSVM est plus efficace et permet de traiter des données dont le nombre d’individus est très important (10) et le nombre d’attributs plus restreint (10). Nous proposons d’utiliser la formule de Sherman-Morrison-Woodbury pour adapter le PSVM à la fouille d’ensembles de données dont le nombre d'attributs est très important et le nombre d’individus plus restreint sur un matériel standard. Puis nous présentons un algorithme de boosting de PSVM pour classifier des données de très grandes tailles en nombre d'individus et d'attributs. Nous évaluons les performances du nouvel algorithme sur les ensembles de données de l’UCI, Twonorm, Ringnorm, Reuters-21578 et Ndc.
Notch 1 interacts with the amyloid precursor protein in a Numb‐independent manner

We hypothesized that the physical interaction between the amyloid precursor protein (APP) and Notch 1 (N1) may be mediating the reported cross‐talk between the respective signaling pathways. Immunoprecipitation of mouse N1 (mN1) or extracellular domain truncated mN1 (mN1‐TM, mimics TACE‐produced membrane‐bound C‐terminal fragment) specifically coprecipitated APP751. Conversely, immunoprecipitation of APP751 specifically coprecipitated mN1, furin‐generated membrane‐bound mN1 C‐terminal fragment (f.mN1‐TM), or mN1‐TM. The London mutation of APP did not affect the APP751/mN1 interaction. Coexpression of APP751 and mN1 did not affect APP processing or production of mN1 intracellular domain (mNICD). The APP751/mN1 interaction was Numb‐independent, insofar as it was observed in HEK293 cells that lack detectable levels of Numb and was unaffected by the expression of exogenous Numb or deletion of the APP cytoplasmic domain, including the Numb‐binding YENPTY sequence. This interaction was unaffected even when the N‐terminal 647 amino acids of APP were replaced by a sequence of secreted alkaline phosphatase. These data combined with data showing interaction between mN1‐TM and APP751 suggest that their transmebrane domains and short sequences around them are sufficient for the interaction and that APP751 and mN1 interact in cis. Our results imply novel functions of APP and/or N1 that derive from their interaction. © 2005 Wiley‐Liss, Inc.
Link Budget Analysis at 915 MHz band for Wireless Sensor Networks

Wireless sensor network has recently emerged as enablers of several areas. Real applications of WSN are being explored and some of them are yet to come. While the potential of sensor networks has been only beginning to be realized, several challenges still remain. One of them is the experimental evaluation of WSN. Therefore, deploying and operating a testbed to study the real behavior of WSN become more and more important. The main contribution of this work is to analysis the RF link budget behavior of wireless sensor networks in underground mine gallery. Keywords—Sensor networks, RF Link, path loss.
Expression, Purification, Physicochemical Characterization and Structural Analysis of Cytochrome c 554 from Vibrio parahaemolyticus Strain RIMD2210633

The function of cytochrome c 554 of Vibrio parahaemolyticus has not yet been determined. We have determined the physicochemical properties and crystal structure of cytochrome c 554 at 1.8 Å in order to help elucidate its function. The physicochemical properties and the tertiary structure of cytochrome c 554 resemble those of dimeric cytochrome c 552 from Pseudomonas nautica, but the Vibrio genus contains no gene for nitrite reductase, cytochrome cd 1, in its genome DNA. These results raise the possibility that both cytochromes denote an electron to an electron carrier and accept an electron from same electron carrier.
Testing measurement invariance across groups: applications in cross-cultural research.

Researchers often compare groups of individuals on psychological variables. When comparing groups an assumption is made that the instrument measures the same psychological construct in all groups. If this assumption holds, the comparisons are valid and differences/similarities between groups can be meaningfully interpreted. If this assumption does not hold, comparisons and interpretations are not fully meaningful. The establishment of measurement invariance is a prerequisite for meaningful comparisons across groups. This paper first reviews the importance of equivalence in psychological research, and then the main theoretical and methodological issues regarding measurement invariance within the framework of confirmatory factor analysis. A step-by-step empirical example of measurement invariance testing is provided along with syntax examples for fitting such models in LISREL
Size Effect on Interlayer Coupling and Magnetoresistance Oscillation of Magnetic Tunnel Junction Embedded With Iron Nanoparticles

Here, we investigate the size effect of perpendicular-anisotropic double-barrier magnetic tunnel junction (MTJ) devices embedded with iron nanoparticles. A sputtering system in conjunction with the postannealing process is employed to prepare the sheet film and standard lithography techniques followed by the ion etching technique are used to fabricate the micrometer to submicrometer MTJ devices. A strong ferromagnetic coupling is observed as we reduce the size of the device to submicrometer scale, which is due to the reduction of magnetostatic energy of the device. Furthermore, a magnetoresistance (MR) oscillation is observed at room temperature while reducing the size of the device. MR peaks at low bias fields are believed to have magnon contributions, whereas the peaks observed at higher bias fields are responsible for phonon-assisted tunneling. Zero-bias anomalies are also observed and are more prominent in antiparallel states of the devices.
Differences in mortality on the basis of laboratory parameters in an unselected population at the Emergency Department

Abstract The objective of this study was to relate multiple laboratory results of initial blood gas analysis in patients visiting the emergency department to mortality. A total of 1806 adult patients visiting the emergency department for any reason, who underwent blood gas analysis, were included in this study. The results of nine laboratory parameters (ionised calcium, potassium, sodium, glucose, lactate, pH, pCO 2, pO 2 and saturation) were related to mortality. Comparison of the means of survivors' and non-survivors' age, pH, pO 2, glucose and lactate showed relevant differences (p≤0.001). When dividing the group of patients into quintiles, hypo- and hyperkalaemia (<3.6 or >4.3mmol/L), hypocalcaemia (<1.12mmol/L), hyperglycaemia (>10.6mmol/L), hyperlactataemia (>2.9mmol/L) and acidosis (pH<7.34) were all related to high mortality in comparison to the quintile with the lowest mortality (p<0.0001). Interestingly, even within the reference range for lactate and ionised calcium, there was an increased risk of mortality, so these reference ranges should be interpreted with care. Glucose and lactate have additional clinical value, but are not always requested. Therefore, glucose and lactate should be routinely added to a blood gas request. Our study shows differences in mortality for laboratory parameters in patients visiting the emergency department, irrespective of the underlying pathology.
La unión económica, social y política: la interpretación del federalismo europeo

La Unión Europea es una realidad que se defme en un proceso continuo de construcción y reformas; y, a estas alturas del proceso, para muchos, no parece haber dudas ni tiene sentido el plantearse cual es la significación de esta Unión. Es decir, menos de los que debieran se replantean cuestiones tan elementales como el propósito y las formulaciones que dan contenido a la Institución Europea. En este sentido advertimos la existencia de una amplia literatura especializada que toma a la Administración Europea como otro mecanismo más, capaz de dar satisfacción automática a determinadas necesidades de los europeos. Estos autores plantean su trabajo de un modo parecido a como lo hacen, por ejemplo, los ingenieros mecánicos que trabajan en el diseño y fabricación de automóviles, y que con su contribución pueden ir mejorando la seguridad, la confortabilidad y otras prestaciones del vehículo, sirviendo en ello a una mejor satisfacción de los intereses de los clientes y los accionistas de la empresa. Para estos autores la "filosofía" de la Unión no parece tener demasiada transcendencia, por que su ciencia está conectada con el mundo real y no con él de las ideas. Contrariamente, aparecen autores que nos enseñan a descubrir en las ideas la auténtica realidad, mucho más rica y compleja que la descrita en los modelos y ficciones de aquellos otros, y para estos "teorizar el federalismo no es ni posible ni conveniente". En este Artículo nos hacemos eco de esa inmensa minoría de autores que cuestionan el afán dogmático con el que se está afrontando la interpretación científica de la Unión Europea desde distintas disciplinas, como la Economía, el Derecho, las Ciencias Políticas, etc. No se trata únicamente de desdeñar aquí ciertos trabajos, cuya utilidad por otra parte es incuestionable, sino de combatir con nuestro análisis los estériles dogmatismos y convicciones que se ofrecen como guías mágicas del proceso de construcción de la nueva Europa. Impulsa esta investigación, el hecho de que muchos de los que han disciplinado el conjunto de estructuras y mecanismos que deben sostener y conducir esta Unión, se han topado con una traviesa realidad que ha escapado de tales disciplinas para escribir su propia historia, casi siempre al margen de los diagnósticos y las recetas de las mejores teoñas. Es obligado, indicar que no es casual la aparición de este Artículo junto al del profesor Leslie, dado que en él se han inspirado, por acuerdo o desacuerdo, algunas de las ideas expresadas en este trabajo, que trata de las posibilidades que nos ofrece la interpretación del federalismo europeo. Y, además nos ha planteado el reto de trasladar las enseñanzas del sistema federal canadiense al caso europeo, sin que en modo alguno a este autor puedan imputársele los muchos errores que seguramente cometamos en nuestros planteamientos.