Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence and Trends of the Leading Cancers with Elevated Incidence Among American Indian and Alaska Native Populations, 2012–2016

Cancer incidence varies among American Indian and Alaska Native (AI/AN) populations, as well as between AI/AN and White populations. This study examined trends for cancers with elevated incidence among AI/AN compared with non-Hispanic White populations and estimated potentially avoidable incident cases among AI/AN populations. Incident cases diagnosed during 2012–2016 were identified from population-based cancer registries and linked with the Indian Health Service patient registration databases to improve racial classification of AI/AN populations. Age-adjusted rates (per 100,000) and trends were calculated for cancers with elevated incidence among AI/AN compared with non-Hispanic White populations (rate ratio >1.0), by region. Trends were estimated using joinpoint regression analyses. Expected cancers were estimated by applying age-specific cancer incidence rates among non-Hispanic White populations to population estimates for AI/AN populations. Excess cancer cases among AI/AN populations were defined as observed minus expected cases. Liver, stomach, kidney, lung, colorectal and female breast cancers had higher incidence rate among AI/AN populations across most regions. Between 2012 and 2016, nearly 5,200 excess cancers were diagnosed among AI/AN populations, with the largest number of excess cancers (1,925) occurring in the Southern Plains region. Culturally informed efforts may reduce cancer disparities associated with these and other cancers among AI/AN populations.
Olive oil effectively mitigates ovariectomy-induced marrow adiposity assessed by MR spectroscopy in estrogen-deficient rabbits

Background Polyphenols in extra virgin olive oil (EVOO) have been found to reduce the expression of PPARγ2, inhibit adipocyte differentiation, and enhance the formation of osteoblasts from bone marrow stem cells. However, the underlying mechanisms of their action remain unknown. Purpose To determine the sequential effects of EVOO on marrow fat expansion induced by estrogen deprivation using 3.0-T proton magnetic resonance (MR) spectroscopy in an ovariectomy (OVX) rabbit model of postmenopausal bone loss over a six-month period. Material and Methods A total of 45 female New Zealand rabbits were equally divided into sham-operation, OVX controls, and OVX treated with EVOO for six months. Marrow fat fraction was measured by MR spectroscopy at baseline conditions, and three and six months postoperatively, respectively. Serum bone biomarkers, lumbar and femoral bone mineral density, microtomographic parameters, biomechanical properties, and quantitative parameters of marrow adipocytes were studied. Results OVX was associated with marrow adiposity in a time-dependent manner, accompanied with increased bone turnover and impaired bone mass and trabecular microarchitecture. In OVX rabbits, EVOO markedly alleviated trabecular bone loss and reduced the accumulation of lipid droplets including adipocyte size, density, and areas of fat deposits in the bone marrow. EVOO prevented such changes in terms of both marrow adiposity and bone remodeling. Conclusion Early EVOO treatment may exert beneficial effects on bone by modulating marrow adiposity, which would support their protective effect against bone pathologies.
In search of the most reproducible neural vulnerability factors that predict future weight gain: analyses of data from six prospective studies

Abstract We tested if we could replicate the main effect relations of elevated striatum and lateral orbitofrontal cortex (OFC) response to high-calorie food stimuli to weight gain reported in past papers in six prospective datasets that used similar functional MRI (fMRI) paradigms. Participants in Study 1 (N = 37; M (mean) age = 15.5), Study 2 (N = 160; M age = 15.3), Study 3 (N = 130; M age = 15.0), Study 4 (N = 175; M age = 14.3), Study 5 (N = 45; M age = 20.8) and Study 6 (N = 49; M age = 31.1) completed fMRI scans at the baseline and had their body mass index (BMI) and body fat (Studies 4 and 6 only) measured at the baseline and over follow-ups. Elevated striatal response to palatable food images predicted BMI gain in Studies 1 and 6 and body fat gain in Study 6. Lateral OFC activation did not predict weight gain in any of the six studies. The result provide limited support for the hypothesis that elevated reward region responsivity to palatable food images predicts weight gain. Factors that make replication difficult are discussed and potential solutions considered.
Study of the stability of aluminium trimeric clusters in aqueous solutions

Ab initio molecular dynamics (AIMD) based on density functional theory has been used to study small aluminium–oxygen complexes in water. Such Al–O clusters have been seen in several recent mass spectrometry studies. In this study, we have focused on trimeric Al–O clusters. The initial very compact trimeric Al–O structures opened up and formed linear Al–O chains. The typical Al–O coordination number in these chain structures was 5. We have performed long (up to 200 ps) AIMD simulations and these chain structures are stable on the nanosecond time scale. We have also studied the reactivity of the Al–O dimer and solvated Al. We found a formation path for the trimeric cluster, which has a action barrier (0.04 eV) and a reaction free energy of − 0.55 eV. This suggests that the association of a dimer and a monomer Al–O species is fast and thermodynamically a very favourable process.
Hydrodynamic advantages of in-line schooling

Fish benefit energetically when swimming in groups, which is reflected in lower tail-beat frequencies for maintaining a given speed. Recent studies further show that fish save the most energy when swimming behind their neighbor such that both the leader and the follower benefit. However, the mechanisms underlying such hydrodynamic advantages have thus far not been established conclusively. The long-standing drafting hypothesis—reduction of drag forces by judicious positioning in regions of reduced oncoming flow–fails to explain advantages of in-line schooling described in this work. We present an alternate hypothesis for the hydrodynamic benefits of in-line swimming based on enhancement of propulsive thrust. Specifically, we show that an idealized school consisting of in-line pitching foils gains hydrodynamic benefits via two mechanisms that are rooted in the undulatory jet leaving the leading foil and impinging on the trailing foil: (i) leading-edge suction on the trailer foil, and (ii) added-mass push on the leader foil. Our results demonstrate that the savings in power can reach as high as 70% for a school swimming in a compact arrangement. Informed by these findings, we designed a modification of the tail propulsor that yielded power savings of up to 56% in a self-propelled autonomous swimming robot. Our findings provide insights into hydrodynamic advantages of fish schooling, and also enable bioinspired designs for significantly more efficient propulsion systems that can harvest some of their energy left in the flow.
Sink strength of citrus rootstocks under water deficit.

Carbon allocation between source and sink organs determines plant growth and is influenced by environmental conditions. Under water deficit, plant growth is inhibited before photosynthesis and shoot growth tends to be more sensitive than root growth. However, the modulation of source-sink relationship by rootstocks remain unsolved in citrus trees under water deficit. Citrus plants grafted on Rangpur lime are drought tolerant, which may be related to a fine coordination of the source-sink relationship for maintaining root growth. Here, we followed 13C allocation and evaluated physiological responses and growth of Valencia orange trees grafted on three citrus rootstocks (Rangpur lime, Swingle citrumelo and Sunki mandarin) under water deficit. As compared to plants on Swingle and Sunki rootstocks, ones grafted on Rangpur lime showed higher stomatal sensitivity to the initial variation of water availability and less accumulation of non-structural carbohydrates in roots under water deficit. High 13C allocation found in Rangpur lime roots indicates this rootstock has high sink demand associated with high root growth under water deficit. Our data suggest that Rangpur lime rootstock used photoassimilates as sources of energy and carbon skeletons for growing under drought, which is likely related to increases in root respiration. Taken together, our data revealed that carbon supply by leaves and delivery to roots are critical for maintaining root growth and improving drought tolerance, with citrus rootstocks showing differential sink strength under water deficit.
Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

The synthesis and assembly of nanoparticles using green technology has been an excellent option in nanotechnology because they are easy to implement, cost-efficient, eco-friendly, risk-free, and amenable to scaling up. They also do not require sophisticated equipment nor well-trained professionals. Bionanotechnology involves various biological systems as suitable nanofactories, including biomolecules, bacteria, fungi, yeasts, and plants. Biologically inspired nanomaterial fabrication approaches have shown great potential to interconnect microbial or plant extract biotechnology and nanotechnology. The present article extensively reviews the eco-friendly production of metalloid nanoparticles, namely made of selenium (SeNPs) and tellurium (TeNPs), using various microorganisms, such as bacteria and fungi, and plants’ extracts. It also discusses the methodologies followed by materials scientists and highlights the impact of the experimental sets on the outcomes and shed light on the underlying mechanisms. Moreover, it features the unique properties displayed by these biogenic nanoparticles for a large range of emerging applications in medicine, agriculture, bioengineering, and bioremediation.
Asian Population Is More Prone to Develop High-Risk Myelodysplastic Syndrome, Concordantly with Their Propensity to Exhibit High-Risk Cytogenetic Aberrations

Simple Summary The world population is genetically and environmentally diverse. In particular, genetic differences related to an ethnic factor may underlie differences in cancer phenotypic expression. Therefore, we compared the epidemiology, and the clinical, biological and genetic characteristics of myelodysplastic syndrome (MDS) between Asian and Western countries. Our results show substantial differences in the incidence and age of onset between Asian and Western MDS patients. A higher proportion of Asian MDS patients fall into the high- and very-high risk prognostic MDS groups. This finding is supported by the identification of a higher proportion of high-risk cytogenetic aberrations in Asian MDS patients. However, the survival rate is similar for Western and Asian MDS patients. Our findings may impact the clinical management as well as the strategy of clinical trials targeting those genetic aberrations and mutations depending on the world area where they are run. Abstract This study explores the hypothesis that genetic differences related to an ethnic factor may underlie differences in phenotypic expression of myelodysplastic syndrome (MDS). First, to identify clear ethnic differences, we systematically compared the epidemiology, and the clinical, biological and genetic characteristics of MDS between Asian and Western countries over the last 20 years. Asian MDS cases show a 2- to 4-fold lower incidence and a 10-year younger age of onset compared to the Western cases. A higher proportion of Western MDS patients fall into the very low- and low-risk categories while the intermediate, high and very high-risk groups are more represented in Asian MDS patients according to the Revised International Prognostic Scoring System. Next, we investigated whether differences in prognostic risk scores could find their origin in differential cytogenetic profiles. We found that 5q deletion (del(5q)) aberrations and mutations in TET2, SF3B1, SRSF2 and IDH1/2 are more frequently reported in Western MDS patients while trisomy 8, del(20q), U2AF1 and ETV6 mutations are more frequent in Asian MDS patients. Treatment approaches differ between Western and Asian countries owing to the above discrepancies, but the overall survival rate within each prognostic group is similar for Western and Asian MDS patients. Altogether, our study highlights greater risk MDS in Asians supported by their cytogenetic profile.
A survey of electron swarm data

An electron swarm consists of a small number density n of electrons in a gas of much higher number density N. The mean energy and energy distribution of such a swarm are determined by the value of E/N where E is the electric field. At any given value E/N the swarm may be characterized by the values of eight parameters, viz; drift velocity, diffusion coefficient. (diffusion coefficient/mobility, excitation coefficient, electron attachment coefficient, electron detachment coefficient, ionization coefficient, recombination coefficient. In this survey, data on these parameters obtained by a variety of experimental techniques are collected, discussed, and compared graphically. Also included on the graphs are computed values of the parameters obtained in many cases from cross sections and energy distributions chosen to give the best fit with the swarm data. Selected tabulations of the data are also given except in cases for which the accuracy of the data is not sufficient to warrant numerical presentation. The .
LncRNA‐GAS5 related to the processes of recurrent pregnancy loss by regulating Th1/Th2 balance

Recurrent pregnancy loss (RPL) is defined as three or more consecutive spontaneous loss of pregnancy and the reason of 50% RPL is unknown. GAS5 is a long non‐coding RNA, which has been found to be an immune responses regulator and to be relate to autoimmune diseases. However, the roles of GAS5 during the pathophysiological processes of RPL is unclear. In the present study, the levels of GAS5 were examined in the plasma and trophoblasts from 30 patients with RPL and 15 healthy controls. GAS5 was found overexpressed in patients with RPL and positively correlated with the protein levels of TNF‐α in the plasma and trophoblasts. Predicted by bioinformatics tools and confirmed by luciferase assay, GAS5 was identified to function as a competing endogenous RNA (ceRNA) binding with miR‐140‐5p and protects TNF‐α expression in HTR‐8/SVneo cells and primary trophoblasts. Activated Naïve T cells co‐cultured with the medium from GAS5 overexpression HTR‐8/SVneo cells or primary trophoblasts exhibited Th1 bias by expression more IFN‐γ, TNF‐α and less IL‐4, IL‐10. In conclusion, GAS5 was overexpressed in the plasma and trophoblasts from RPL patients, which contributes to Th1 bias by binding with miR‐140‐5p.
The Spatial Ingroup Bias: Ingroup Teams Are Positioned Where Writing Starts

In four studies, we test the hypothesis that people, asked to envisage interactions between an ingroup and an outgroup, tend to spatially represent the ingroup where writing starts (e.g., left in Italian) and as acting along script direction. Using soccer as a highly competitive intergroup setting, in Study 1 (N = 100) Italian soccer fans were found to envisage their team on the left side of a horizontal soccer field, hence playing rightward. Studies 2a and 2b (N = 219 Italian and N = 200 English speakers) replicate this finding, regardless of whether the own team was stronger or weaker than the rival team. Study 3 (N = 67 Italian and N = 67 Arabic speakers) illustrates the cultural underpinnings of the Spatial Intergroup Bias, showing a rightward ingroup bias for Italian speakers and a leftward ingroup bias for Arabic speakers. Findings are discussed in relation to how space is deployed to symbolically express ingroup favoritism (Spatial Ingroup Bias) versus shared stereotypes (Spatial Agency Bias).
Factors Influencing Farmer Participation in the Environmentally Sensitive Areas Scheme

Abstract This study investigates factors influencing farmers' motivations for participation in the Cambrian Mountains ESA scheme (Wales, U.K.). Emphasis is placed on analysing whether significant correlations exist between ESA participation and specific factors. A behavioural approach is used for analysis, largely based on Brotherton's classification into “scheme factors” (e.g. payments) and “farmer factors” (e.g. age of farmer), but which expands this classification by including the “information environment” of a farmer and “dynamics within the farm district”—variables which this study shares with some actor-network approaches. While size and existence of remnant wildlife habitats were strongly correlated with overall participation, payments offered by the scheme, information provided by ADAS, scheme flexibility, the “successors factor” and dynamics within the district were of particular importance for participation on farms of marginal ESA eligibility (i.e. small farms lacking substantial semi-natural habitats). Age, education and length of residency were important for explaining differential entering of specific habitats (especially broadleaved woodlands) into the ESA scheme, while scheme duration, dependence on the farm for income, tenure and the general information environment of the farmer did not influence overall participation. The paper concludes by arguing that a behavioural approach offers a valuable insight into farmers' decision-making behaviour with regard to participation in agri-environmental schemes, and that this study may be seen as a starting point that could be expanded through the use of related methodologies.
The Novel Halovirus Hardycor1, and the Presence of Active (Induced) Proviruses in Four Haloarchaea

The virus Hardycor1 was isolated in 1998 and infects the haloarchaeon Halorubrum coriense. DNA from a frozen stock (HC1) was sequenced and the viral genome found to be 45,142 bp of dsDNA, probably having redundant, circularly permuted termini. The genome showed little similarity (BLASTn) to known viruses. Only twenty-two of the 53 (41%) predicted proteins were significantly similar to sequences in the NCBI nr protein database (E-value ≤ 10−15). Six caudovirus-like proteins were encoded, including large subunit terminase (TerL), major capsid protein (Mcp) and tape measure protein (Tmp). Hardycor1 was predicted to be a siphovirus (VIRFAM). No close relationship to other viruses was found using phylogenetic tree reconstructions based on TerL and Mcp. Unexpectedly, the sequenced virus stock HC1 also revealed two induced proviruses of the host: a siphovirus (Humcor1) and a pleolipovirus (Humcor2). A re-examination of other similarly sequenced, archival virus stocks revealed induced proviruses of Haloferax volcanii, Haloferax gibbonsii and Haloarcula hispanica, three of which were pleolipoviruses. One provirus (Halfvol2) of Hfx. volcanii showed little similarity (BLASTn) to known viruses and probably represents a novel virus group. The attP sequences of many pleolipoproviruses were found to be embedded in a newly detected coding sequence, split in the provirus state, that spans between genes for integrase and a downstream CxxC-motif protein. This gene might play an important role in regulation of the temperate state.
Production of HIV-1 Env-Specific Antibodies Mediating Innate Immune Functions Depends on Cognate Interleukin-21- Secreting CD4+ T Cells

To develop a vaccine or immunotherapy that would cure the HIV-1 infection, it is important to identify helper T cells able to mount an efficient antibody response. Here, we demonstrate that the generation of HIV-1 Env-specific antibodies facilitating antibody-dependent innate immune responses likely depends on Env-specific IL-21-secreting CD4+ T and peripheral T follicular helper cells. ABSTRACT Antibodies with a functional Fc region were previously associated with protection from HIV-1 acquisition and spontaneous suppression of viral replication. Unlike broadly neutralizing antibodies, they are not restricted to neutralizing epitopes and do not require unconventional structural traits to exert their antiviral activity. They therefore develop earlier after infection and can be detected in the majority of cases. The conditions under which these antibodies are generated, however, remain largely unknown. Here, we demonstrate that the generation of HIV-1 Env-specific antibodies facilitating Fc-dependent innate immune responses, including neutrophil phagocytosis (ADNP), complement deposition (ADCD), and NK cell activation, likely depends on help provided by CD4+ T and peripheral T follicular helper (pTfh) cells secreting interleukin-21 (IL-21). Other proteins, including CD40L, gamma interferon (IFN-γ), and IL-4/13, involved in cross talk between B and T cells were linked to the production of antibodies with a functional Fc region but only when coexpressed with IL-21. As a potential source of these antibodies, we identified a subset of Env-specific memory B cells known to be expanded in chronic HIV-1 infection. The frequency and level of Blimp-1 expression in Env-specific tissue-like memory B cells (TLM) correlated with the functional CD4+ T cell subsets associated with robust antibody-dependent innate responses. Thus, our data suggest a mechanism responsible for the generation of antibodies with functional Fc region in chronically HIV-1-infected individuals that is based on CD4+ T cell-induced activation of memory B cells. IMPORTANCE To develop a vaccine or immunotherapy that would cure the HIV-1 infection, it is important to identify helper T cells able to mount an efficient antibody response. Here, we demonstrate that the generation of HIV-1 Env-specific antibodies facilitating antibody-dependent innate immune responses likely depends on Env-specific IL-21-secreting CD4+ T and peripheral T follicular helper cells.
Physical and mechanical characteristics of short fiber-reinforced resin composite in comparison with bulk-fill composites.

PURPOSE The objective of this study was to evaluate the physical and mechanical properties of a short fiber-reinforced resin composite: everX-Posterior and compare it with two bulk-fill composites, namely, Filtek Bulk-fill and Beautifil-Bulk, which are intended for large posterior restorations. METHODS Investigated properties were flexural strength, flexural modulus, surface roughness, volumetric shrinkage and depth of cure. Scanning electron microscopy images of each specimen after the flexural test were used for cross-sectional comparison. Results were analyzed using ANOVA following Tukey post-hoc test. RESULTS Flexural strength of everX-Posterior was comparable with two other resin composites, showing higher flexural modulus. EverX-Posterior showed the highest surface roughness after polishing and the lowest volumetric shrinkage (2.29%) among all composites used in this study. Data also showed that the everX-Posterior depth of cure was 4.24 mm, which was the highest among the three groups. CONCLUSION Based on the results of this study, it was concluded that everX-Posterior as a short fiber-reinforced composite showed improvements and satisfactory performance in mechanical and physical properties, which make it a reliable base material candidate for large posterior restorations.