Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing models of the mammalian cell S phase

The accurate replication of the mammalian genome is a complex and logistically challenging process. The entirety of the genome must undergo a single duplication with as little error as possible. This must occur in a coordinated fashion and over suitably short time scale so as to allow timely cellular division within a cell cycle that is typically around 24 hours in a human cell. A great wealth of knowledge already exists describing various aspects of the S phase, during which this replication of the genome occurs. This data has been gathered over a variety of model systems, ranging from inferences from the replicative mechanics of SV40 through to direct observations of replication in mammalian cells.In order integrate this data and determine the value of inferences from different data sources, quantitative models of the mammalian cell S phase are required. This study documents the development of several such models and the exploration of the influences that experimentally determined parameters and different mechanistic theories can have on the behaviour of a simulated S phase. Of particular exploratory interest were the modes of activating replication of replicon clusters, with the aim of simulating experimentally observed dynamics. Additionally, the study also aimed to investigate the variation of replication fork rates and the density of origins of replication, along with the relationship that occurs between the two during both replicational stress and during a normal S phase. Through an iterative series of models, relevant parameters and key theories are sequentially explored so as to better understand the S phase. Particularly influential parameters were identified and studied in detail, with experimental determination where necessary in order to more accurately inform the model system. Conclusions concerning the behaviour of the system and the potential impact of the results were drawn upon the completion of each level of modelling and experimental work.To conclude the study, a linear model simulating the genome of the MRC5 cell line was used to estimate the modes activation of DNA replication along chromosomes in order to recreate experimentally observed replication dynamics. Experimentally determined profiles of replication fork rates and the density of origin firing were also determined for the MRC5 cell line, and were used to populate the model with accurate and appropriate data. Using the model to simulate S phase through a variety of behavioural parameters, realistic S phase dynamics were found to occur through a combination of de novo activation of replicon clusters and a specific probability of neighbour activation by completed clusters. These derived mechanics, when performed on a system correctly parameterised with suitable data, can simulate experimentally observed phenomena. The development of the model highlighted the requirements of data fit for purpose, and the study also stresses the need for critical consideration of inferences made between different model systems.
An Ads-Csab Approach For Economic Denial Of Sustainability Attacks In Cloud Storage

: Cloud computing is a crucial technology for the data stored in the cloud storages by the organization future. The cloud security is the biggest challenge for cloud providers and a major concern for cloud adopters. Economic Denial of Sustainability (EDoS) is an important attack towards the cloud service providers. The Cloud service provider will receive many requests at a particular second by the attackers. It leads a problem in providing the service to the legitimate users. The legitimate users paid the amount for the service but they can‘t access the data. This problem makes economical issues to the users. The attack defence shell (ADS) provided a secured service but the performance metrics are less. In this proposed work a new method ADS-CSAB Approach for EDoS attack is developed, that is resilient to these types of misbehavior. As performance and cost indicators, the improved EDoS shield strategy even outperforms the initial EDoS-Shield.
Perioperative Nursing Care of a Patient with Middle Thoracic Esophageal Carcinoma

Objective: To explore the clinical nursing of esophageal carcinoma in perioperative period. Method: Giving targeted nursing treatment to the patient in mental, diet nursing, oral cavity, air tube and digestive tract before surgery; after the operation, strengthening the management of air tube, drainage tube, pain nursing and complication after the operation. Result: By the targeted nursing intervention in perioperative period, the patient was operated successfully; his condition was stable during recovery time and had no postoperative complication. He completed clinical treatment plan and left hospital on time. Conclusion: Taking comprehensive nursing intervention in perioperative period of esophageal carcinoma is conducive to reduce postoperative complications, accelerate recovery and increase nursing satisfaction.
INTERNATIONAL SOCIETY FOR SOIL MECHANICS AND GEOTECHNICAL ENGINEERING

Industrial enterprises aim at committing the lowest amount of resources and time to deliver a satisfactory product to the client. In the civil engineering industry failure to deliver a satisfactory product, in the form of structures and infrastructures which meet the required performance, may result in huge costs and loss of life. Conversely large uncertainties on the performance may also result in an unnecessarily safe and wasteful design. In the present time, considering the environmental impact of construction activities and the rapid depletion of finished resources, wasteful design is becoming ethically inacceptable. This paper discusses some issues that are specific of geotechnical engineering, where uncertainties are larger and the use of subjective engineering judgement and personal experience is more important than in other disciplines. Particular attention is given to problematic aspects of major projects, like the fragmentation of tasks in many sub-packages and the ensuing difficulty in managing the flow of information at the many interfaces. Practical suggestions are given to improve the compliance to ethical requirements in the geotechnical activity of large consulting companies. RÉSUMÉ : Les entreprises industrielles désirent minimiser l’usage de ressources et de tempes qui est nécessaire à obtenir un produit satisfaisant pour le client. Dans l’ «industrie» du génie civil n’obtenir pas un produit satisfaisant, sous forme de structures ou infrastructures qui parviennent au comportement spécifiée, peut résulter en coûts énormes et même faire de victimes. Réciproquement, grandes incertitudes sur le résultat peuvent aussi produire un projet excessivement sûre et gaspilleuse. Aujourd'hui, à raison de l'impact de les activités de construction sur l'environnement et de l'épuisement rapide de ressources finies, les projets gaspilleurs deviennent éthiquement inacceptables. Ce papier discute des problèmes qui sont spécifiques de la géotechnique, où les incertitudes sont plus grandes, et l'usage du jugement subjectif et de l’expérience personnelle est plus important, que dans autres disciplines. Un’ attention particulière est ici donnée aux aspects problématiques de gros projets, comme la fragmentation des actions dans beaucoup des sous-activités et la difficulté de gérer le flux d'informations a les nombreuses interfaces. Des suggestions pratiques pour améliorer la conformité aux critères éthiques de l'activité géotechnique dans les grosses sociétés de génie conseil sont, enfin, proposée.
Effect of Business Performance on Taxation of Small and Medium Enterpries Scale in Bwari Area Council FCT Abuja, Nigeria

Tax remains a veritable means of developing a modern day economy and apart from the major sources of taxes such as Company Income Tax, Value Added Tax and Withholding-Tax. Apart from these taxes there is also taxation of the informal sector such as the SMEs. This study investigated the effects of business performance on taxation of Small and Medium Enterprise scale (SMEs) in Bwari Area Council FCT, Abuja. The study had a population of 156 and a sample size of 112 which was arrived at using Yamane sampling model. Data was gathered using questionnaires administered to the respondents and was analyzed using multiple regression technique. The findings revealed that return on assets and staff recruitment had positive and significant effect on taxation of SMEs in Bwari Area Council of FCT, Abuja. It was recommended amongst others that SMEs should engage in cost saving measures to boost their profits which encourage payment of taxes. It was also recommended that SMEs should employ optimally, their required numbers of staff to boost payment of taxation to Bwari Area Council FCT, Abuja
Insights into Epigenetics Mechanisms in Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is one of the most common oral cancers accounting for 96% of all head and neck cancers. Beside the different endogenous and environmental risk factors, epigenetics play an important role in causing OSCC. Epigenetics shed light on the presence of inherited changes in the phenotype of a gene with the absence of an alteration in the DNA sequence. The epigenetic modifications can result in the emersion of cancer, autoimmune diseases, aging and other diseases. Under several circumstances, DNA undergoes methylation. This methylation might be related to normal development or serious diseases like cancer. DNA methylation is a heritable biochemical modification occurs predominantly by transferal of a methyl group to C5 position of the cytosine ring (CpGs) which may cause epigenetic disturbances. This review aims toward investigating the genetics in literature to help in diagnosing OSCC with new modalities that are less invasive compared to histopathology. Studied genes including ECAD, DAPK, MGMT and P53 has different methylation frequencies in relation to OSCC which may be related to their significant role in early diagnosis and prognosis. Since genetics has a major role in OSCC, we searched most recently reported genes and technologies seeking early detection and treatment of OSCC results in a better prognosis and more conservative treatment.
“A study of Employee productivity management system adopted by the Hotel Industry with special reference to Hyderabad & Bangalore cities”

The characteristics of service industry make productivity management in such industries more difficult and challenging. Hotel industry being a part of such a service industry faces a similar problem. This study is aimed at analyzing and comparing the Productivity Management System adopted and implemented by the hotel industry of Hyderabad & Bangalore cities with an objective to identify the challenges in measuring productivity in the Hotels and to identify various methods adopted by them to measure employee productivity. The findings of his research states that although the industry is concerned with the issues related to employee productivity, the implementation of the productivity management system is not very effective. The major reasons contributing to the ineffectiveness of the system are lack of management will, lack of common parameters of productivity measurement and intangible nature of the product of the industry i.e. “Service”.
Intermediation Cost and Non-Performing Financing:

The instinct of bankers is to keep the borrowers alive through recycling and renewals of bad loans into loans, a window dressing exercise; or worse yet, advancing additional fresh loans to effectively insolvent borrowers to tide over what is perceived as cash flow problems and forthcoming illiquidity, thereby getting deeper into financial distress. In this sense, insolvency occurs first, illiquidity follows later. Increase in the intermediation costs lead to increase in Non-performing Loans (NPLs). The intermediation cost reflects the operating efficiency of banks. If credit risk is not managed properly it eventually shows up in NPLs, or the concentration of banking credit in a few sectors of the economy, or in a few segment of borrowers, or a rising proportion of riskier loans in its portfolio during times of rapid expansion of banking credit. This paper studies intermediation costs in credit markets within a dynamic Stiglitz and Weiss (1981) framework. The theoretical predictions of our model gains support by Pakistani banks’ quarterly data for the period 2007-09. Data suggests that an increase in intermediation costs results in an increase in NPLs. Analyses show that, if intermediation cost is administered properly, it ultimately lowers NPLs. We argue that minimization of intermediation costs improves financial soundness.
Analysis of motivating factors for visiting wineries in the Vršac wine region (Vojvodina, Serbia)

The paper will present the research results of motivational factors influencing wine tourists in decision making process regarding their visits to the wineries in the Vršac wine region, an area which belong to South Banat wine region according to the official regionalization and comprises the west slopes of Vršac mountains (South East Vojvodina). The aim of the paper is to analyse visitors of the Vršac wineries in order to establish components of the motivation and to define the influence they have on the decision to participate in the wine tourism in this region. The methodology of this approach entails: defining and establishing the importance of wine tourism, identifying motivating factors in wine tourism, followed by definition and analysis of the most relevant motivating factors of the wine tourist visiting the Vršac wineries, establishing the intensity of their attitudes related to certain factors and, finally, offering recommendations to the Vršac wineries management in order to create the high quality marketing mix aimed at clearly defined target markets and to position successfully in the wine tourism market. One of the conclusions is that the visitors to the Vršac wineries regard wine tasting as the most important motivating factor, followed by socializing and relaxation.
Low nutrient Eucalyptus wood chip agar: a semi-quantitative medium for assessing melanin production by Cryptococcus gattii

Cryptococcus gattii is commonly associated with Eucalyptus spp. and is able to cause potentially serious disease in immunocompromised humans. As the virulence factors of many fungi are thought to have evolved in response to environmental pressures, it is important to understand their expression in association with environmental factors. We report here that melanisation, a key virulence factor that aids survival of C. gattii in its environment, is induced in culture by propagating the fungus on a modified agar supplemented with Eucalyptus wood chips. Furthermore, this medium provides a semi-quantitative assessment of melanin production that differs with major C. gattii genotypes. Melanin production on the Eucalyptus agar was enhanced when the concentration of peptone and glucose were limited, suggesting that melanisation may be induced in C. gattii as a response to nutrient stress.
The Analysis of Economic Growth in the Countries Member of Islamic Conference with the Emphasis on the Role

The determination of the effective factors on economical growth rate of the countries was always taken into attention by economists and policy makers. In the theories presented in economical growth, some factors as Export diversification, research and development, human capital are emphasized and considering the openness of the economy and financial development in growth models, we can deal with achieving high growth of economy. In this study, analysis of economical growth in Islamic conference countries are studied by emphasis on the role (Export diversification, human capital, research and development, openness of economy and financial development) (2000-2009) by econometric technique of panel data. The results show that the effect of Export diversification, human capital, research and development, openness of economy and financial development were positive and significant. The results of the study showed that for higher economical growth of the investigated countries, a strategic view should be prevalent in Export diversification variables, human capital, research and development, openness of economy and financial development.
Composition Kills: A Case Study of Email Sender Authentication

Component-based software design has been widely adopted as a way to manage complexity and improve reusability. The approach divides complex systems into smaller modules that can be independently created and reused in different systems. One then combines these components together to achieve desired functionality. Modern software systems are commonly built using components made by different developers who work independently.
Catalogue of the Smaller Arachnid Orders of the World: Amblypygi, Uropygi, Schizomida, Palpigradi, Ricinulei and Solifugae

This authoritative catalogue will greatly assist readers in finding the correct taxonomic name for any given family, genus or species within each of the six arachnid orders treated. It contains a valuable summary of bibliographic information, enabling readers to access the worldwide literature for these smaller orders. The catalogue presents full bibliographic data on each of the taxa named thus far, treating over 1600 species. It contains the most current classification system for each group, some of which have not been catalogued on a world scale for over 70 years. A summary of taxonomic changes is included. This quality reference will be of immense value to arachnologists, systematists, taxonomists, ecologists and biodiversity professionals, especially those interested in tropical rainforest communities.
TREE SPECIES USED BY BIRDS IN LOGGED AND UNLOGGED MIXED-CONIFEROUS FORESTS

A number of studies have examined the possible ways birds use their habitat to permit optimum exploitation and to allow coexistence of different species. Habitat partitioning may occur if, for example, each species possesses a characteristic foraging height distribution (Hartley 1953, Morse 1968, Diamond 1973). Birds may also divide the vegetation into various horizontal levels (Colquhoun and Morley 1943, MacArthur 1964, Balda 1969). Individuals of a given species may also primarily restrict their activities to specified zones in the tree such as the trunk or outer branches (Hartley 1953, MacArthur 1958, Morse 1967a, 1967b, Stallcup 1968, Sturman 1968, Koch et al. 1970). There is evidence that some avian species do have preferences for certain plant species (Hartley 1953, Morse 1967b, Balda 1969, Willson 1970, Jackson 1970, Austin and Smith 1972). These factors by acting individually or in concert may interact to produce habitat partitioning for the various avian species in the community. It has been suggested that plant species diversity has little effect on a community's bird species diversity which instead, is dependent upon foliage height diversity, at least in homogeneous environments (MacArthur and MacArthur 1961). It is the vegetation profile which determines bird species diversity and not the number of plant species present. Yet, the nature of the vegetation may be important in a heterogeneous environment. MacArthur (1964) found that in the complex environment of the Chiricahua Mountains, Arizona, birds "apparently used more than just profile in selecting suitable habitats; presumably the addition of nest holes and water, the change from oak to pine and from sparse to dense foliage, all made significant changes in the acceptability of the habitat for many species. " It appears that birds do not regard all trees of the same height and profile, belonging to different species, as being equally desirable for activities such as foraging and nesting. The purpose of this investigation was to determine if birds select certain tree species in a mixed-coniferous forest, and if so, to what extent the use of a logged area differs from that of a virgin forest. Results from this study may suggest some guidelines for future timber harvesting practices in the Southwest.
A new balanced direction for multi-objective evolutionary algorithms

- This paper suggests to use a new improvement direction for multi-objective evolutionary algorithms. In DMEA-II, two improvement directions (convergence and spread) are used for the guidance during evolutionary processes. Based on those directions and the balance between exploration and exploitation, we determined a new improvement direction to keep DMEA-II to be better on the balance of convergence and diversity. To validate the performance of the new improved version of DMEA-II, we carried out a case study on several test problems and comparison with well-known MOEAs, it obtained quite good results on primary performance metrics, namely the generation distance, inverse generation distance and hypervol-ume. Our analysis on the results indicates that, the usage of proposed direction may make DMEA-II to be improved in keeping balanced between convergence and diversity at each generation during the search.
Synthesis Of Zinc Oxide Nanoparticles (ZNO- NPS) Via Green Approach For Enhanced Antimicrobial Activity Against Human Pathogenic Bacteria (HPB) Strains

Eco-friendly approach using marine macroalgae Turbinaria ornata (TO) aqueous extract was developed for the formation of zinc oxide nanoparticles (ZnO-NPs) without employing any stabilizer and a chemical surfactant. By a benign process we have synthesized TOZnO-NPs through green process which has economic benefits and eco-friendly over chemical and physical methods. The TOZnO-NPs structural and textural features were characterized by various analytical techniques such as UV-visible spectrophotometer, XRD, SEM, EDX, DLS, Fe-SEM and FTIR. In-vitro antimicrobial activity of TOZnO-NPs displayed high antimicrobial potency on selective gram negative and positive human pathogenic bacteria (HPB). Antimicrobial activity portrayed higher inhibition activity 16 mm against Escherichia coli (NCIM 2931) andminimal 12 mm in Staphylococcus aureus (NCIM 5021). Anti-microbial mechanism of TOZnO-NPs employed a biphasic phenomenon persuading by osmotic shock that could attack the cell wall directly leads to death. These findings clearly implicate that green TOZnO-NPs is a new paradigm to mitigate the HPB strains.
The relationship between lifecourse accumulated income and childbearing of Swedish men and women born 1940-1970

Abstract: Research on income and fertility has largely focused either on the cross-sectional relationship between income and current number of children or income the year before childbearing. In the current study, a novel and superior measure of income and earnings is introduced to assess whether poorer or richer individuals have more children. Accumulated income histories are calculated and presented for men and women in contemporary Sweden for cohorts born between 1940 and 1970 using administrative register data. The study shows how income is related to completed fertility and parity for two different operationalization of income: disposable income and earnings. There is a strong positive gradient between accumulated income and fertility for men for all cohorts, and a gradual transformation from a negative to a positive gradient for women. In particular, childless men and women have substantially lower accumulated incomes than do men and women with children. For men, fertility increases monotonically with increasing income, while for women much of the positive gradient is the result of low fertility among women with very low accumulated income in later cohorts.