Miracle-dz/UniFAR-FTUs huggingface dataset:
The comparison between CBT focused on perfectionism and CBT focused on emotion regulation for individuals with depression and anxiety disorders and dysfunctional perfectionism: a randomized controlled trial

Abstract Background: There is considerable evidence indicating that similar aetiological and maintenance processes underlie depressive and anxious psychopathology. According to the literature, perfectionism and emotion regulation are two transdiagnostic constructs associated with symptoms of emotional disorders. Aims: This study is the first randomized controlled trial comparing the efficacy of cognitive behavioural therapy for perfectionism (CBT-P) and the unified protocol for the transdiagnostic treatment of emotional disorders (UP). Method: Seventy-five participants with a range of depressive and anxiety disorders and elevated perfectionism were randomized to three conditions: CBT-P, UP or a waitlist control (WL). Results: Repeated measures ANOVA indicated that the treatment groups reported a significantly greater pre–post reduction in the severity of symptoms of disorders, as well as a significantly greater pre–post increase in quality of life, all with moderate to large effect sizes compared with the WL group. Treatment gains were maintained at 6-month follow-up. The CBT-P group reported a significantly greater pre–post reduction in perfectionism compared with UP, and the UP group reported a significantly greater pre–post improvement in emotion regulation compared with CBT-P. Conclusions: Findings support CBT for perfectionism and regard UP as efficacious treatments for individuals with depression and anxiety disorders who also have dysfunctional perfectionism. It appears that perfectionism cannot be a serious obstacle to UP. As this is a preliminary study and has some limitations, it is recommended that further research be conducted.
Synthesis, Characterization, and Optical-Limiting Properties of Axially Substituted Gallium(III) Naphthalocyanines

The soluble axially substituted naphthalocyanine monomers, tBu4NcGaCl (1) and tBu4NcGa(p-TMP) (p-TMP = p-trifluoromethylphenyl) (2) and the μ-oxo-bridged naphthalo-cyanine dimer [tBu4NcGa]2O (3) are synthesized under mild conditions. In comparison to the corresponding gallium phthalocyanine compounds, tBu4PcGaCl, tBu4PcGa(p-TMP), and [tBu4PcGa]2O, all gallium naphthalocyanines 1−3 are almost transparent in the yellow and red region of the UV/vis spectrum, suggesting that they are suitable for eye protection in a practical optical-limiting device. These compounds optically limit at sufficiently high intensity via a reverse saturable absorption mechanism into the excited T−T absorption band at 532-nm excitation. The substitution of the axially p-TMP ligand onto the central gallium atom results in a defocusing of the beam relative to the other gallium naphthalocyanine compounds. This added defocusing of the beam is important and desirable in practical optical limiters as it helps to spatially disperse the pu.
Golimumab (anti-TNF monoclonal antibody): where we stand today

ABSTRACT Tumor necrosis factor (TNF) is a pro-inflammatory cytokine and its overexpression has been implicated in the pathophysiology of several chronic immune-mediated inflammatory diseases. Biological therapies, like TNF inhibitors, have been revolutionizing the course of these disorders. Golimumab is a transgenic anti-TNF monoclonal antibody that acts primarily by targeting and neutralizing TNF, thus preventing inﬂammation. It is approved for the treatment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Nonradiographic axial Spondyloarthritis, Juvenile Idiopathic Arthritis, and Ulcerative Colitis. Clinical trials are also being conducted in other conditions. This review charts the clinical development of golimumab and outlines the data that support its potential use across several Immune-mediated inflammatory diseases.
Radicicol, a Novel Lead Compound against the Migratory-Stage Schistosomula of Schistosoma japonicum

Schistosomiasis poses a serious threat to human health and remains a major tropical and parasitic disease in more than 70 countries. Praziquantel (PZQ) has been the primary treatment for schistosomiasis for nearly 4 decades. ABSTRACT Schistosomiasis poses a serious threat to human health and remains a major tropical and parasitic disease in more than 70 countries. Praziquantel (PZQ) has been the primary treatment for schistosomiasis for nearly 4 decades. However, its efficacy against migratory-stage schistosomula is limited. Radicicol (RAD), a β-resorcylic acid lactone derived from Paecilomyces sp. strain SC0924, was investigated as an alternative treatment for Schistosoma japonicum. In vitro tests showed that within 72 h, RAD (10 μmol/liter) completely killed schistosomula of both skin and liver stages with an efficacy significantly higher than that of PZQ, although it was less potent against adult worms than PZQ. In vivo, RAD reduced worm burdens and liver eggs by 91.18% and 86.01%, respectively, by killing migratory-stage schistosomula. Optical microscopy and scanning electron microscopy revealed that RAD damaged the epiderm and tegument morphology of S. japonicum worms at various stages and altered their motility to different degrees. RAD exhibited schistosomicidal effects at different stages in vitro and in vivo, especially at the migratory stage, implying that its mechanism could be different from that of PZQ. Collectively, these results showed that RAD is promising as a lead for the development of drugs to control the migratory-stage schistosomula of S. japonicum.
Racial dynamics among clients in a residential substance use disorder treatment program in South Los Angeles and its impact on clients' treatment experiences

Abstract This study seeks to investigate racial dynamics among clients in a female-only residential substance use disorder treatment facility in South Los Angeles and its effects on treatment experiences. Clients were interviewed about their interracial interactions, perceptions of clients of races and ethnicities different from their own and how racial dynamics might affect their experiences in treatment. Nine interviews were conducted and analyzed using thematic analysis. Participants recounted that racial differences do not play a significant role in their treatment experiences, although racial identities shape social group formation. Motivation to recover from addiction and other shared lived experiences facilitate interracial harmony.
Comparative genomics reveals dynamic genome evolution in host specialist ectomycorrhizal fungi.

While there has been significant progress characterizing the 'symbiotic tool kit' of ectomycorrhizal (ECM) fungi, how host specificity may be encoded into ECM fungal genomes remains poorly understood. We conducted a comparative genomic analysis of ECM fungal host specialists and generalists, focusing on the specialist genus Suillus. Global analyses of genome dynamics across 46 species were assessed, along with targeted analyses of three classes of molecules previously identified as important determinants of host specificity: small secreted proteins (SSPs), secondary metabolites (SMs), and G-protein coupled receptors (GPCRs). Relative to other ECM fungi, including other host specialists, Suillus had highly dynamic genomes including numerous rapidly evolving gene families and many domain expansions and contractions. Targeted analyses supported a role for SMs but not SSPs or GPCRs in Suillus host specificity. Phylogenomic-based ancestral state reconstruction identified Larix as the ancestral host of Suillus, with multiple independent switches between white and red pine hosts. These results suggest that like other defining characteristics of the ECM lifestyle, host specificity is a dynamic process at the genome level. In the case of Suillus, both SMs and pathways involved in the deactivation of reactive oxygen species appear to be strongly associated with enhanced host specificity.
Elastically Effective Chains in Transient Gels with Multiple Junctions

Most thermoreversible gels have multiple junctions combining more than two network chains. The number of chains bound together in a single junction is called the multiplicity of the junction. On the basis of the Scanlan−Case criterion, the numbers of elastically effective chains and effective junctions in thermoreversible gels with multiple junctions are calculated as functions of the polymer concentration and the temperature for several important types of multiplicity distribution. It is found that the number of elastically effective chains increases as the cube of the concentration deviation near the sol/gel transition concentration and reaches an asymptotic high-concentration region where it increases proportionally to the concentration. The result is compared with the observed elastic moduli of associating polymers.
Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9‐month equine groove model study

This study aimed to quantify the long‐term progression of blunt and sharp cartilage defects and their effect on joint homeostasis and function of the equine carpus. In nine adult Shetland ponies, the cartilage in the radiocarpal and middle carpal joint of one front limb was grooved (blunt or sharp randomized). The ponies were subjected to an 8‐week exercise protocol and euthanized at 39 weeks. Structural and compositional alterations in joint tissues were evaluated in vivo using serial radiographs, synovial biopsies, and synovial fluid samples. Joint function was monitored by quantitative gait analysis. Macroscopic, microscopic, and biomechanical evaluation of the cartilage and assessment of subchondral bone parameters were performed ex vivo. Grooved cartilage showed higher OARSI microscopy scores than the contra‐lateral sham‐operated controls (p < 0.0001). Blunt‐grooved cartilage scored higher than sharp‐grooved cartilage (p = 0.007) and fixed charge density around these grooves was lower (p = 0.006). Equilibrium and instantaneous moduli trended lower in grooved cartilage than their controls (significant for radiocarpal joints). Changes in other tissues included a threefold to sevenfold change in interleukin‐6 expression in synovium from grooved joints at week 23 (p = 0.042) and an increased CPII/C2C ratio in synovial fluid extracted from blunt‐grooved joints at week 35 (p = 0.010). Gait analysis outcome revealed mild, gradually increasing lameness. In conclusion, blunt and, to a lesser extent, sharp grooves in combination with a period of moderate exercise, lead to mild degeneration in equine carpal cartilage over a 9‐month period, but the effect on overall joint health remains limited.
Bovine brucellosis – a comprehensive review

Abstract Brucellosis is a zoonotic disease of great animal welfare and economic implications worldwide known since ancient times. The emergence of brucellosis in new areas as well as transmission of brucellosis from wild and domestic animals is of great significance in terms of new epidemiological dimensions. Brucellosis poses a major public health threat by the consumption of non-pasteurized milk and milk products produced by unhygienic dairy farms in endemic areas. Regular and meticulous surveillance is essentially required to determine the true picture of brucellosis especially in areas with continuous high prevalence. Additionally, international migration of humans, animals and trade of animal products has created a challenge for disease spread and diagnosis in non-endemic areas. Isolation and identification remain the gold standard test, which requires expertise. The advancement in diagnostic strategies coupled with screening of newly introduced animals is warranted to control the disease. Of note, the diagnostic value of miRNAs for appropriate detection of B. abortus infection has been shown. The most widely used vaccine strains to protect against Brucella infection and related abortions in cattle are strain 19 and RB51. Moreover, it is very important to note that no vaccine, which is highly protective, safe and effective is available either for bovines or human beings. Research results encourage the use of bacteriophage lysates in treatment of bovine brucellosis. One Health approach can aid in control of this disease, both in animals and man.
Deceleration area and capacity during labour‐like umbilical cord occlusions identify evolving hypotension: a controlled study in fetal sheep

Cardiotocography is widely used to assess fetal well‐being during labour. The positive predictive value of current clinical algorithms to identify hypoxia‐ischaemia is poor. In experimental studies, fetal hypotension is the strongest predictor of hypoxic‐ischaemic injury. Cohort studies suggest that deceleration area and deceleration capacity of the fetal heart rate trace correlate with fetal acidaemia, but it is not known whether they are indices of fetal arterial hypotension.
Role of the RNF213 Variant in Vascular Outcomes in Patients With Intracranial Atherosclerosis

Background The RNF213 (ring finger protein 213 gene) variant R4810K is a susceptibility allele not only for Moyamoya disease (MMD) but also for intracranial atherosclerosis (ICAS) in East Asian populations. We hypothesized that this variant would affect the distribution of ICAS and recurrence of cerebrovascular events. Methods and Results We conducted a prospective study of patients with ICAS and MMD using high‐resolution magnetic resonance imaging and RNF213 R4810K genotyping. Patients were included in the ICAS group when relevant plaques existed on high‐resolution magnetic resonance imagingand in the MMD group when they carried the variant and high‐resolution magnetic resonance imaging showed no plaques but characteristic features of MMD. We compared clinical and neuroimaging features of patients with ICAS‐RNF213+ with patients with ICAS‐RNF213− and of patients with MMD. Of 477 patients, 238 patients were in the ICAS group and 239 were in the MMD group. Among patients with ICAS, 79 patients (33.2%) were in the ICAS‐RNF213+ group and 159 (66.8%) in the ICAS‐RNF213− group. Tandem lesions were significantly more common in the ICAS‐RNF213+ group than in the ICAS‐RNF213− group (40.3% versus 72.2%, P<0.001), and their distributions were similar between the ICAS‐RNF213+ and MMD groups. The presence of the R4810K variant (hazard ratio [HR], 3.203; 95% CI, 1.149–9.459; P=0.026) and tandem lesions (≥3) (HR, 8.315; 95% CI, 1.930–39.607; P=0.005) were independently associated with recurrent cerebrovascular events. Conclusions Patients with ICAS carrying the RNF213 R4810K variant showed clinical and imaging features distinct from patients with ICAS without the variant, suggesting that the R4810K variant plays a role in intracranial atherosclerosis in East Asian patients.
Molecular mechanisms involved in functional macroevolution of plant transcription factors.

Transcription factors are key components of the transcriptional regulation machinery. In plants, they accompanied the evolution from unicellular aquatic algae to complex flowering plants that dominate the land environment. The adaptations of the body plan and physiological responses required changes in the biological functions of transcription factors. Some ancestral gene regulatory networks are highly conserved, while others evolved more recently and only exist in particular lineages. The recent emergence of novel model organisms opened the chance for comparative studies, providing new insights to infer these evolutionary trajectories. In this review, we comprehensively revisit the recent literature in transcription factors of non-seed plants and algae focusing on the molecular mechanisms driving their functional evolution. We discuss the particular contribution of changes on DNA binding specificity, protein-protein interactions and cis-regulatory elements to gene regulatory networks. Current advances showed that these evolutionary processes were shaped by changes in transcription factors expression pattern but not great innovation in transcription factor protein sequences. We propose that transcription factor role associated with environmental and developmental regulation were unevenly conserved during land plant evolution.
Predicting peak symmetry in capillary zone electrophoresis : The concept of the peak shape diagram

Electrophoretic peaks generally deviate from the symmetrical Gaussian shape that is expected when diffusion is the dominant dispersion factor. A basic understanding of the electromigrational dispersion processes which give rise to peak asymmetry shows that these effects are related to the difference in mobilities between the sample ions and the buffer electrolyte ions. There is a currently adopted rule saying that if the mobility of the buffer co-ion is higher than that of the analyte, a tailing peak is obtained, while a lower mobility of the buffer co-ion results in a fronting peak. Unfortunately, the phenomena observed in practice are frequently contradictory to these rules. This paper reveals the principles of these effects and establishes a way to proceed in explaining and predicting the peak shape in electrophoresis. Based on a mathematical model of zone migration in capillary electrophoresis, the key parameter controlling the migration dynamics is found to be the velocity slope, defined as the chang.
Gastroesophageal reflux and asthma: when, how, and why

Purpose of review Gastro-esophageal reflux is a possible cause of uncontrolled symptoms of asthma and should be actively investigated and treated before severe asthma is diagnosed and biological therapy started. Recent findings Recent investigations on esophageal function and tissue biomarkers in patients with asthma and associated GERD have established a relevant role for esophageal motility and neuronal sensory abnormalities in linking the two diseases. Characterization of the underpinning inflammatory substrate has showed mixed results as both neutrophilic and eosinophilic type 2 inflammatory changes have been described. Summary New findings regarding inflammatory mechanisms in GERD-associated asthma as well as new diagnostic tools to investigate functional esophageal abnormalities and characterize asthma endotype have identified potential treatable traits that may improve the clinical management and outcome of asthmatic patients with GERD.
RETRACTED ARTICLE: Multimodal exercises integrated with cognitive-behavioural therapy improve disability of patients with failed back surgery syndrome: a randomized controlled trial with one-year follow-up

We, the Editor and Publisher of the journal Disability and Rehabilitation, have retracted the following article: Marco Monticone, Emilia Ambrosini, Barbara Rocca, Daniele Cazzaniga, Valentina Liquori, Alessio Lovi & Marco Brayda-Bruno (2022) Multimodal exercises integrated with cognitive-behavioural therapy improve disability of patients with failed back surgery syndrome: a randomized controlled trial with one-year follow-up. Disability and Rehabilitation, 44:14, 3422–3429, DOI: 10.1080/09638288.2020. 1863480 Since publication, concerns have been raised regarding the integrity of the data in the article. When approached for an explanation, the authors provided detailed responses, but were unable to provide an explanation that satisfactorily addressed our concerns, which includes the veracity of the data presented in the article. The authors have been informed of the decision to retract. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
Analysis of ionic equilibria and electrowinning of indium from chloride solutions

The effects of variables on the current efficiency and cell voltage of indium electrowinning from chloride solution have been examined. Ionic equilibria for the InCl 3 -HCI-NaOH-H 2 O system at 25°C was analyzed and the experimentally measured pH values agreed well with those calculated from the analysis. The initial pH of electrolyte solution, reaction temperature and current density had negligible effect on the current efficiency and cell voltage increased linearly with increasing current density. In order to achieve current efficiency of 90% at the current density of 100 mA/cm 2 , the initial concentration of indium and NaCI should be higher than 50 g/L.
MRGBP, a member of the NuA4 complex, inhibits DNA double‐strand break repair

The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. The nucleosome acetyltransferase of H4 (NuA4) remodeler complex enables DNA break repair by relaxing flanking chromatin. Here, we show that MRG domain binding protein (MRGBP), a member of this complex, acts as a general inhibitor of DNA double‐strand break repair. Upon its downregulation, repair is generally increased. This is particularly evident for the stimulation of early events of homologous recombination. Thus, MRGBP has an opposing role to the main catalytic subunits of the NuA4 complex. Our data suggest that MRGBP acts by limiting the activity of this complex in DNA repair, specifically by narrowing the extent of DNA‐end resection.
Effects of industrial back-support exoskeletons on body loading and user experience: an updated systematic review

Abstract This study is an updated systematic review of papers published in the last 5 years on industrial back-support exoskeletons. The research questions were aimed at addressing the recent findings regarding objective (e.g. body loading, user performance) and subjective evaluations (e.g. user satisfaction), potential side effects, and methodological aspects of usability testing. Thirteen studies of active and twenty of passive exoskeletons were identified. The exoskeletons were tested during lifting and bending tasks, predominantly in laboratory settings and among healthy young men. In general, decreases in participants’ back-muscle activity, peak L5/S1 moments and spinal compression forces were reported. User endurance during lifting and static bending improved, but performance declined during tasks that required increased agility. The overall user satisfaction was moderate. Some side effects were observed, including increased abdominal/lower-limb muscle activity and changes in joint angles. A need was identified for further field studies, involving industrial workers, and reflecting actual work situations. Practitioner summary: Due to increased research activity in the field, a systematic review was performed of recent studies on industrial back-support exoskeletons, addressing objective and subjective evaluations, side effects, and methodological aspects of usability testing. The results indicate the efficiency of exoskeletons in back-load reduction and a need for further studies in real work situations. Abbrevaitions: BB: biceps brachii; BF: biceps femoris; CoM: centre of mass; DA: deltoideus anterior; EMG: electromyography; ES: erector spinae; ES-C: erector spinae-cervical; ESI: erector spinae iliocostalis; ESI-L: erector spinae iliocostalis-lumborum; ESL: erector spinae longissimus; ES-L: erector spinae-lumbar; ESL-L: erector spinae longissimus-lumborum; ESL-T: erector spinae longissimus-thoracis; ES-T: erector spinae-thoracic; GM: glutaeus maximus; LBP: low back pain; LD: latissimus dorsi; LPD: local perceived discomfort scale; LPP: local perceived pressure scale; MS: multifidus spinae; MSD: musculoskeletal disorder; M-SFS: modified spinal function sort; NMV: no mean value provided; OA: obliquus abdominis (internus and externus); OEA: obliquus externus abdominis; OIA : obliquus internus abdominis; RA: rectus abdominis; RF: rectus femoris; RoM: range of motion; SUS: system usability scale; T: trapezius (pars Ascendens and Descendens); TA: trapezius pars ascendens; TC: mid-cervical trapezius; TD: trapezius pars descendens; VAS: visual analog scale; VL: vastus lateralis; VM: vastus medialis