Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of prior administration of cold saline on pain during propofol injection

A single‐blind, randomised, controlled study was undertaken to compare the efficacy of three methods of preventing pain during injection of propofol on induction of anaesthesia. Patients were allocated randomly to receive unmodified propofol, propofol with 0.05% lignocaine, propofol at 4°C and unmodified propofol preceded by 10 ml of 0.9% saline at 4°C. Prior injection of cold saline reduced the incidence of pain and discomfort significantly (22%) compared with unmodified propofol (75%; p < 0.005) and was similar to that after cold propofol (33%) and propofol with lignocaine (44%). There was no significant difference between the treatment groups.
Work Packet Manager: exploiting heterogeneity in cluster computing

In expensive high performance computer systems combined with high speed networks and machine-independent communication libraries have made cluster computing a viable option for parallel application programs. Heterogeneity is quite common in this environment, especially in processor architectures: rapid technological change means that as elements are added to or replaced in such a system. In this paper, we analyze a technique for exploiting this heterogeneity to improve the performance of parallel applications in cluster system. The Work Packet Manager (WPM) library is a general and extensible work scheduler, which mimics Cilk's dynamic scheduler, for MPI. The experimental results demonstrate the performance benefit of the WPM library in heterogeneous cluster environment
Long‐term in vivo imaging of normal and pathological mouse spinal cord with subcellular resolution using implanted glass windows

• Chronic in vivo imaging of cellular interactions within the adult spinal cord with subcellular resolution is important for understanding cellular physiology and disease progression. • Previous approaches for chronic in vivo spinal cord microscopy have required surgery for each imaging session. • Here we describe a novel method for implanting glass windows over the exposed spinal cords of adult mice for repeated in vivo microscopy. • We show that the windows remain clear for many months after implantation, do not damage axons or blood vessels, and are useful for studying cellular dynamics after spinal cord injury. • Our method represents an original technical breakthrough for scientists involved in spinal cord research and in vivo imaging, and is a useful tool for studying cellular physiology and disease progression.
INTELLECTUAL CAPITAL IN METROPOLITAN HOTELS

Hospitality operations are focused on human capital needed to the tough competition of knowledge economy. Hotel management is already cautious regarding structural and financial capital and therefore strategies have been developed for improvements and value creation on those assets. Hence, intellectual capital value of a hotel has become the resource of innovation as well as the competitive advantage. This study has been realized to propose an exploration of the relation among performance factors, quality measures and the intellectual capital of hotels. A specific scorecard is defined in order to analyze the focus points, the barriers and the relations among the human, structural and customer capital strategies. The scorecard was run on four and five star hotels in Istanbul to appraise the distinction of quality as represented by stars. The statistical analysis of the data allows us to test the relationship between performance and the intellectual capital. This study will contribute both to academicians and practitioners by introducing a new vision.
Engaging bodies in the public imagination: Bioarchaeology as social science, science, and humanities

Bioarchaeology is the contextual analysis of biological remains from past societies. It is a young and growing discipline born during the latter half of the twentieth century from its roots in physical anthropology and archaeology. Although often associated with the study of ancient diet and disease, bioarchaeology leverages variable temporal scales and its global scope to provide a uniquely comparative perspective on human life that transcends traditional boundaries of the natural sciences, social sciences, and humanities. Here, we explore the public face of bioarchaeology and consider the trends in publication practices that reflect diversifying research strategies.
[Recent etiology and clinical features of acute viral hepatitis in a single center of Korea].

BACKGROUND AND AIMS The etiology of acute viral hepatitis in Korea has been dynamically changing during the recent years. The aim of this study was to investigate the recent etiology and the clinical features of acute viral hepatitis in a single center of Korea. METHODS We performed a retrospective analysis of a prospective cohort of 55 patients who were diagnosed with acute viral hepatitis A to E during the period from May 2005 to August 2006. In addition to the clinically acute manifestations, the confirmatory serological tests were performed for the diagnosis of acute hepatitis A, B, C and E. RESULTS The proportion of patients with acute viral hepatitis A, B, C, E and others were 56.4% (n=31), 12.7% (n=7), 18.2% (n=10), 9.1% (n=5) and 3.6% (n=2), respectively. The mean age of the patients with acute hepatitis A, B, C and E were 29.1+/-4.38, 38.7+/-11.72, 45.3+/-17.62 and 32.4+/-6.58 years, respectively. There was no fatal case. All cases of acute hepatitis B and six out of ten cases of acute hepatitis C recovered spontaneously. Four out of the five patients with acute hepatitis E had no history of travel to endemic area. CONCLUSIONS The most common etiology of acute viral hepatitis in Korea is hepatitis A virus, and hepatitis C and B virus were the next most common causes. The sporadic cases of acute hepatitis E were not rare, and coinfection of HAV and HEV was observed. A multicenter, prospective study is warranted in the future.
Cloning and Expression of Vacuolar Proton-Pumping ATPase Subunits in the Follicular Epithelium of the Bullfrog Endolymphatic Sac

Abstract In an investigation aimed at clarifying the mechanism of crystal dissolution of the calcium carbonate lattice in otoconia (the mineral particles embedded in the otolithic membrane) of the endolymphatic sac (ELS) of the bullfrog, cDNAs encoding the A- and E-subunits of bullfrog vacuolar proton-pumping ATPase (V-ATPase) were cloned and sequenced. The cDNA of the A-subunit consisted of an 11-bp 5′-untranslated region (UTR), a 1,854-bp open reading frame (ORF) encoding a protein comprising 617 amino acids with a calculated molecular mass of 68,168 Da, and a 248-bp 3′-UTR followed by a poly(A) tail. The cDNA of the E-subunit consisted of a 72-bp 5′-UTR, a 681-bp ORF encoding a protein of 226 amino acids with a calculated molecular mass of 26,020 Da, and a 799-bp 3′-UTR followed by a poly(A) tail. Western blot and immunofluorescence analyses using specific anti-peptide antisera against the V-ATPase A- and E-subunits revealed that these subunits were present in the ELS, urinary bladder, skin, testes, and kidneys. In the ELS, positive cells were scattered in the follicular epithelium which, as revealed by electron microscopy, corresponds to the location of mitochondria-rich cells. These findings suggest that V-ATPase, including the A- and E-subunits, exists in mitochondria-rich cells of the ELS, which might be involved in dissolution of the calcium carbonate crystals in the lumen of the ELS.
Load shifting potential of the washing machine and tumble dryer

Various smart grid pilots are being initiated worldwide to explore the flexibility in electricity demand of households. The potential flexibility of appliances can be unlocked using either manual or (semi-)automated demand response. In the Dutch smart grid pilot Your Energy Moment the effect of demand response is studied. The participating households are equipped with a smart washing machine or smart tumble dryer. These appliances can be used to manually respond to the dynamic tariff applied in the pilot, or cycles can be programmed to automatically respond to price fluctuations. Based on the pilot results, the total load shift of the washing machine and tumble dryer is quantified. Subsequently, the effect of the program function is studied, focusing on the use of this function and on the flexible hours provided for the schedule horizon. The results show that the load of the smart appliances is shifted in time. This load shift is a consequence of both manual and semi-automated load shift. The latter, semi-automated load shift related to the use of the program function, is however limited. Both the measured manual and semi-automated load shift did not change over time, indicating a structural change in behavior.
Opportunistic sightings of killer whales from Scottish pelagic trawlers fishing for mackerel and herring off North Scotland (UK) between 2000 and 2006

Les observations d'orques (Orcinus orca), a partir des chalutiers pelagiques ou d'autres types de bateaux, sont relevees dans plusieurs regions de l'Atlantique Nord-Est; cependant, tres peu d'informations sont disponibles, en ce qui concerne ces observations dans les peches de maquereaux (Scomber scombrus) et de harengs (Clupea harengus) dans les eaux entre le nord-est de l'Ecosse et la Norvege. Maquereau et hareng sont deux principales especes recherchees par la flotte pelagique ecossaise, d'octobre a mars, et de juin a septembre, respectivement. Les observations d'orques ont ete enregistrees durant janvier et fevrier 2006 par des observateurs embarques a bord de chalutiers pelagiques pechant le maquereau dans ce secteur. Ces donnees recentes, avec celles recoltees depuis 2000, demontrent l'existence de frequentes rencontres entre chalutiers et orques. Nous decrivons le comportement « fourrageant » de ces orques, manifeste lors des operations de peche. Les orques approchent les bateaux durant les operations de tri du chalut, et restent la jusqu'a la fin. Ils sont vus aussi lors du releve du chalut bien qu'aucun contact avec le bateau ou le filet n'ait ete observe alors. Il n'y a pas de certitude que la presence des orques reduise la quantite de poissons captures par les chalutiers ou meme que les orques s'empetrent dans les filets. Nous pensons que durant la saison de peche au maquereau, les orques tirent de cette source, une part significative de leurs besoins energetiques journaliers.
Small Vessels – Big Problems : Novel Insights into Microvascular Mechanisms of Diseases Purinergic glio-endothelial coupling during neuronal activity : role of P 2 Y 1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex

Peter Toth, Stefano Tarantini, Antonio Davila, M. Noa Valcarcel-Ares, Zsuzsanna Tucsek, Behzad Varamini, Praveen Ballabh, William E. Sonntag, Joseph A. Baur, Anna Csiszar, and Zoltan Ungvari Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Neurosurgery, University of Pecs, Pecs, Hungary; Szentagothai Research Center, Medical School, University of Pecs, Pecs, Hungary; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Institute for Diabetes, Obesity, and Metabolism and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Biological Sciences Department, Biola University, La Mirada, California; Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York; Department of Pediatrics, Regional Neonatal Center, Maria Fareri Children’s Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York; The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Does Delaware Incorporation Affect Executive Compensation? An Empirical Analysis

Motivated by agency theory, this study attempts to ascertain whether chief executive compensation is influenced by legal rules. In particular, we analyze whether Delaware law has an impact on CEO pay. Legal rules have been argued to impact agency conflicts. Agency costs, in turn, affect CEO compensation. Thus, we contend that Delaware law influences CEO pay through their associations with agency problems. The empirical evidence corroborates this hypothesis, showing that Delaware firms pay their CEOs significantly more generously than do non-Delaware firms (about 36% higher in total compensation). Furthermore, Delaware firms exhibit significantly lower pay-performance sensitivity (almost 50% lower), implying that the higher pay more likely reflects rent expropriation rather than shareholder wealth maximization.
Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor

Acetylation of core histone tails plays a fundamental role in transcription regulation. In addition to acetylation, other posttranslational modifications, such as phosphorylation and methylation, occur in core histone tails. Here, we report the purification, molecular identification, and functional characterization of a histone H4–specific methyltransferase PRMT1, a protein arginine methyltransferase. PRMT1 specifically methylates arginine 3(Arg 3) of H4 in vitro and in vivo. Methylation of Arg 3 by PRMT1 facilitates subsequent acetylation of H4 tails by p300. However, acetylation of H4 inhibits its methylation by PRMT1. Most important, a mutation in theS-adenosyl-l-methionine–binding site of PRMT1 substantially crippled its nuclear receptor coactivator activity. Our finding reveals Arg 3 of H4 as a novel methylation site by PRMT1 and indicates that Arg 3 methylation plays an important role in transcriptional regulation.
Płatności bezpośrednie w kontekście dochodów polskich rolników

Od momentu integracji Polski z Unię Europejską obserwuje się istotny wzrost dochodów gospodarstw rolnych. W 2008 r. , pod względem wysokości przeciętnego miesięcznego dochodu rozporządzalnego na 1 gospodarstwo domowe, gospodarstwa rolników ustępowały jedynie dochodom gospodarstw osób pracujących na własny rachunek. Istotny wpływ na tą sytuację mają płatności bezpośrednie, które są czynnikiem dochodotwórczym w polskim rolnictwie. Przeprowadzone badania własne pozwoliły stwierdzić, że praca w gospodarstwie rolnym nie była jedynym źródeł dochodu gospodarstw domowych ankietowanych rolników. Prawie połowa (49,2%) z nich posiadała inne źródła dochodu (renty, emerytury, praca sezonowa w kraju lub za granicą, własna działalność gospodarcza). Prawie 67% ankietowanych dostrzegło poprawę swojej sytuacji dochodowej w wyniku otrzymywanych płatności bezpośrednich. W opinii 7,6% nie uległa ona zmianie.
How Light Reaches the Eye and Its Components

The human eye is exquisitely sensitive to light (i.e., visible radiant energy), and when dark-adapted, the retina can detect a few photons of blue-green light. It is therefore not at all surprising that ocular tissues are also more vulnerable to ultraviolet (UV) and light damage than the skin. For this reason, humans have evolved with certain anatomical, physiological, and behavioral traits that protect this critical organ from the UV damage that would otherwise be certain from the intense bath of overhead solar ultraviolet radiation (UVR) when we are outdoors during daylight. For example, the UV exposure threshold dose for photokeratitis (“welders' flash” or “snow blindness”)—if measured as falling on a horizontal ground surface—would be reached in less than 10 minutes around midday in the summer sun. There are three critical ocular structures that could be affected by UV exposure: the cornea, the lens, and the retina. The cornea transmits radiant energy only at 295 nm and above. The crystalline lens absorbs almost all incident energy to wavelengths of nearly 400 nm. In youth, a very small amount of UV-A reaches the retina, but the lens becomes more absorbing with age. Thus there are intraocular filters that effectively filter different parts of the UV spectrum and allow only of the order of 1% or less to actually reach the retina. Nevertheless, this small fraction of energy—if phototoxic—could still be of concern. Finally, oblique rays entering the eye from the temporal side, can actually reach the equatorial (germinative) area of the lens.
Postadoption von Social Games - Eine empirische Studie

Im Markt für elektronische Spiele wächst in den letzten zwei Jahren kaum ein Segment so dynamisch wie die Social Games. Charakteristische Merkmale dieser Spiele sind ihre Verbindung mit sozialen Netzwerken, eine relativ einfache Spielmechanik und Freemium-Geschäftsmodelle. Die vorliegende Studie unternimmt eine explorative Untersuchung von Social Games aus Sicht der Spieler in der Postadoptionsphase. Dazu wurden acht (N=8) Spieler zu Nutzungsgeschichte, Unterhaltungserleben, sozialer Interaktion und Akzeptanz des Geschäftsmodells befragt. Im Ergebnis zeigt sich, dass die Einfachheit und eher geringe Komplexität dem Wunsch nach Entspannung entgegen kommt. Die Spiele stehen in einer engen Wechselwirkung mit den Motivationen zur Nutzung sozialer Netzwerkdienste. Sie fördern die Interaktion und die Pflege von Beziehungen und bringen Themen in die Kommunikation. In Bezug auf die direkte Monetarisierung zeigen die Befragten erhebliche Widerstände, die insbesondere mit sozialen Normen in Verbindung gebracht werden können. Indirekten Monetarisierungsstrategien stehen vor allem Sicherheitsund Privatheitsbedenken entgegen.
PENGARUH PERISTIWA KENAIKAN HARGA BBM 18 NOVEMBER 2014 PADA ABNORMAL RETURN SAHAM INDUSTRI TRANSPORTASI DI BEI

The purpose of this study is to determine significant difference on abnormal return of Transportation Industry shares before and after the rise of fuel prices on 18 November 2014.This study took a sample of 24 companies in transportation industry listed on Indonesia Stock Exchange by using cencus method. Data analysis technique used was Paired Sample T-Test with 15-day window period. The results show that there was no significant difference on shares’ abnormal return before and after the rise of fuel price on 18 November 2014. The event of fuel prices hike did not give a significant impact on transportation industry, indicating that the issue of fuel prices hike had been widely circulated within the community before the event occured and it did not take place in a long period of time. It can be stated that the market does not react toward the rise of fuel prices. Investors have predicted that the rise of fuel prices will only be temporary and Indonesia Stock Exchange is still being the destination for foreign investors to invest
A Review of Radiation Protection Requirements and Dose Estimation for Staff and Patients in CT Fluoroscopy

The combination of fluoroscopically guided interventional procedures with computed tomography (CTF) has become widespread around the world. The benefits of CTF include the ability to obtain a real-time visualization of the entire body, increased target accuracy and improved visualization of biopsy needles. Modern CTF units work with variable frame rates for image selection, and therefore the dose distributions for patients and staff can considerably vary, creating growing concern in terms of the occupational exposure of interventionists and the drawback of a higher exposure of the patient. A literature review of the latest CTF publications is summarized in this article. A wide range of CTF studies reveal different treatment methods used in clinical practice, and therefore the differences in the exposures between them; as well as in the radiation protection tools and dose monitoring. Further optimization of radiation protection methods, harmonization of exposure patterns as well as training and education of CTF staff on the basis of the information in the survey, are strongly recommended.
A CMOS baseline holder (BLH) for readout ASICs

As a result of a cooperation between Brookhaven National Laboratory and eV Products a generation of high performance readout ASICs was developed. One of the novel circuit solutions implemented in the ASICs is the baseline holder (BLH), a system which provides setting and stabilization of the output baseline both at low frequency and at high rate operation. The BLH is conceptually different from the baseline restorer (BLR). With a output peaking voltage 2V (10 fC), a peaking time 400 ns and a rate 500 kHz, an asymptotic shift of the base-line <8 mV was measured.
Understanding the impediments of adopting co-creation within medium and large enterprises

Disclaimer This document contains a student thesis (bachelor's or master's), as authored by a student at Eindhoven University of Technology. Student theses are made available in the TU/e repository upon obtaining the required degree. The grade received is not published on the document as presented in the repository. The required complexity or quality of research of student theses may vary by program, and the required minimum study period may vary in duration.
A new approach for the determination of ECAP thresholds†

Background: Electrically evoked compound action potentials (ECAPs) of the auditory nerve are routinely recorded for testing the cochlear implant integrity and its functional connection to the auditory system. The response thresholds derived from ECAP recordings are widely used as a helpful guide in the fitting of the dynamic range of electric stimulation, although they may not always predict the behavioral thresholds of individuals well. Conventionally, this threshold is based on the identification of a minimum N peak and maximum P peak and linear extrapolation of the resulting amplitude growth function (AGF). As an alternative, a new procedure involving numeric signal processing and requiring less user intervention is presented here. Data acquisition: In 12 adults implanted with MED-EL FLEX28 electrodes, two series of ECAPs were recorded immediately after implantation: (i) a full profile involving all 12 channels across the whole stimulus range in steps of 200 current units and (ii) a high resolution section (20 records in the immediate neighborhood of the threshold) of the AGF in one selected channel. Data treatment: It was observed that N and P wave latencies do not depend on stimulus intensity. Fixed time windows were hence defined for stimulus plus noise and noise alone regions. In these windows, the variance of the compound signal representing response and noise is extracted, whereas the noise variance is extracted from the tail of the curve following this time window. The base line is corrected by fitting an exponential function to reduce stimulus or amplifier artifacts. The response threshold is then derived from the response to noise ratio which should exceed the limit of 6 dB. Results: The ECAP thresholds obtained from the new procedure coincide well with those determined by the conventional linear extrapolation of the AGF and they correlate to a greater degree with psychometric thresholds than the existing approach. Conclusions: The new ECAP algorithm looks promising and may reduce the need for user intervention in determining thresholds.