Miracle-dz/UniFAR-FTUs huggingface dataset:
The T to R transition in the copper(II)-substituted insulin hexamer. Anion complexes of the R-state species exhibiting type 1 and type 2 spectral characteristics.

The R-state conformation of the Cu(II)-substituted insulin hexamer has been identified, and a number of its derivatives have been studied via 1H NMR, ESR, and UV-visible spectroscopy. This work establishes that the Cu(II)-substituted insulin hexamer undergoes an analogous T to R conformational transition in solution that has been identified previously for Zn(II)- and Co(II)-insulin hexamers [Roy, M. , Brader, M.L. , Lee, R. W. -K. , Kaarsholm, N.C. , Hansen, J., & Dunn, M.F. (1989) J. Biol. Chem. 264, 19081-19085]. The data indicate that each Cu(II) center of the R-state Cu(II)-insulin hexamer possesses a coordination site that is accessible to anions from solution. Both phenol and anionic ligands that coordinate to the Cu(II) ions are required to generate the necessary heterotropic interactions that stabilize the R-state structure. With phenylmethylthiolate (PMT), a Cu(II)-R6 adduct that displays the spectral features of blue (type 1) copper proteins is obtained. This complex is proposed to embody a pseudotetrahedral CuIIN3S(PMT) chromophore, in which N is HisB10 (imidazolyl). The remaining ligands examined gave rise to Cu(II)-R6 adducts that possessed the spectral characteristics of normal (type 2) Cu(II) proteins. Under reducing conditions, Cu(I)-T6 and Cu(I)-R6 hexamers have been identified.
A survey of privacy vulnerabilities and defenses in geosocial networks

Geosocial networks (GSNs) are a popular extension of the growing online social networking phenomenon. The wealth of personal information voluntarily revealed by subscribers, however, exposes them to a wide range of privacy vulnerabilities. In this article we describe basic GSN features and show how external attackers can exploit them in order to gain access to sensitive user information. We introduce several properties that need to be satisfied by a viable, privacy preserving GSN solution. We survey the body of work addressing GSN attacks and privacy issues, and compare their ability to satisfy the crystallized properties. Finally, we propose several open research directions.
Revisiting the Corporate Social and Financial Performance Link: A Contingency Approach

This study draws on and extends contingency theory, in relation to stakeholder theory to understand the corporate social performance (CSP) and financial performance (CFP) link, by evaluating under what circumstances CSP influences CFP. Contingencies include stakeholder configurations/salience and crisis conditions. Using differentiated measures of CSP, this study examined financial effects of various specific stakeholder facing activities pre- and post-crisis in the food/beverage and pharmaceutical industries, and in firms selling search versus experience goods. The results indicate that pre-crisis CSP is related to post-crisis financial effects, but the relationships are dependent on the interactions among the contingencies studied, so investments in certain social areas improve CFP, whereas others may hurt it. This confirms that a finer grained approach should be taken to the examination of CSP and CFP. On a practical basis, it shows that deep stakeholder knowledge and attention to complementary factors to CSP, such as advertising, must be understood, so CSP activities are of benefit to the firm
The servicescape encounter and its impact on repurchase banking service Empirical study in Trade Bank Iraqi (TBI)

The current research aims to analyze the nature of the servicescape and of the encounter and its impact on customer decisions repeating and repurchase. As it illustrates the nature of the research in the physical environment of (TBI) as perceived by customers and the impact of atmosphere on customer service decisions to repeat purchase service from the bank. Sample were selected of 105 customers in Trade Bank of Iraq, the adoption of the questionnaire was to measure trends and attitudes of customers to re-purchase of the bank, the scale was based on previous studies of the nature of the adapted after the banking sector. A statistical tools were used as (mean, standard deviation, Cronbach's alpha, test F, Test T). To build the scale and test hypotheses. The study found that the positive impressions of the customers for the servicescape of the encounter had a significant impact in stimulating customers to repeat purchase and sustain their relationship with (TBI). Thus study recommended increasing the interior environment of interest to the bank and waits for the most important and secures entrances to the bank hall to ensure positive attitudes by the customer and inducing a repeat purchase, and the continuation of its relationship with the bank.
Calcium-dependent and -independent hetero-oligomerization in the synaptotagmin family.

Synaptotagmins constitute a family of membrane proteins that are characterized by one transmembrane region and two C2 domains. Recent genetic and biochemical studies have indicated that oligomerization of synaptotagmin (Syt) I is important for expression of function during exocytosis of synaptic vesicles. However, little is known about hetero-oligomerization in the synaptotagmin family. In this study, we showed that the synaptotagmin family is a type I membrane protein (N(lumen)/C(cytoplasm)) by introducing an artificial N-glycosylation site at the N-terminal domain, and systematically examined all the possible combinations of hetero-oligomerization among synaptotagmin family proteins (Syts I-XI). We classified the synaptotagmin family into four distinct groups based on differences in Ca(2+)-dependent and -independent oligomerization activity. Group A Syts (III, V, VI, and X) form strong homo- and hetero-oligomers by disulfide bonds at an N-terminal cysteine motif irrespective of the presence of Ca(2+) [Fukuda, M. , Kanno, E. , and Mikoshiba, K. (1999) J. Biol. Chem. 274, 31421-31427]. Group B Syts (I, II, VIII, and XI) show moderate homo-oligomerization irrespective of the presence of Ca(2+). Group C synaptotagmins are characterized by weak Ca(2+)-dependent (Syts IX) or no homo-oligomerization activity (Syt IV). Syt VII (Group D) has unique Ca(2+)-dependent homo-oligomerization properties with EC(50) values of about 150 microM Ca(2+) [Fukuda, M. , and Mikoshiba, K. (2000) J. Biol. Chem. 275, 28180-28185]. Syts IV, VIII, and XI did not show any apparent hetero-oligomerization activity, but some sets of synaptotagmin isoforms can hetero-oligomerize in a Ca(2+)-dependent and/or -independent manner. Our data suggest that Ca(2+)-dependent and -independent hetero-oligomerization of synaptotagmins may create a variety of Ca(2+)-sensors.
Performance Evaluation of Predictive Classifiers for Pregnancy Care

Hypertensive disorders are the leading cause of deaths during pregnancy. Risk pregnancy accompaniment is essential to reduce these complications. Decision support systems (DSS) are important tools to patients' accompaniment. These systems provide relevant information to health experts about clinical condition of the patient anywhere and anytime. In this paper, a model that uses the Na&#239;ve Bayesian classifier is introduced and its performance is evaluated in comparison with the Data Mining (DM) classifier named J48 Decision Tree. This study includes the modeling, performance evaluation, and comparison between models that could be used to assess pregnancy complications. Evaluation analysis of the results is performed through the use of Confusion Matrix indicators. The founded results show that J48 decision tree classifier performs better for almost all the used indicators, confirming its promising accuracy for identifying hypertensive disorders on pregnancy.
Suppression of DNA replication via Mos function during meiotic divisions in Xenopus oocytes.

Meiosis is characterized by the absence of DNA replication between the two successive divisions. In Xenopus eggs, the ability to replicate DNA develops during meiotic maturation, but is normally suppressed until fertilization. Here we show that development of the DNA‐replicating ability depends on new protein synthesis during meiosis I, and that mere ablation of the endogenous c‐mos product Mos allows maturing oocytes to enter interphase and replicate DNA just after meiosis I. Moreover, we demonstrate that during normal maturation cdc2 kinase undergoes precocious inactivation in meiosis I and then premature reactivation before meiosis II; importantly, this premature cdc2 reactivation absolutely requires Mos function and its direct inhibition by a dominant‐negative cdc2 mutant also results in nuclear reformation and DNA replication immediately after meiosis I. These findings indicate that suppression of DNA replication during meiotic divisions in Xenopus oocytes is accomplished by the Mos‐mediated premature reactivation of cdc2 kinase. We suggest that these mechanisms for suppressing DNA replication may be specific for meiosis in animal oocytes, and that the ultimate biological function, including the well known cytostatic factor activity, of Mos during meiotic maturation may be to prevent undesirable DNA replication or parthenogenetic activation before fertilization.
Synchronous machine exciter circuit model in a simultaneous field winding interface

This paper presents the implementation of a phase domain (PD) synchronous machine (SM) model through modified-augmented-nodal-analysis (MANA) formulation for the computation of electromagnetic transients. This formulation provides a direct and simultaneous electrical connection to the SM field winding, and enables accurate modeling of its exciter as an electrical side. Detailed exciter modeling can be used to study exciters transient performance and potential failure conditions in its circuit components. This paper also presents and tests a simple current source interface for existing dq0-type SM machine models with control signal input for field control. Realistic test cases are used to validate and compare the proposed models.
Narrative Decision-Making in Investment Choices: How Investors Use News About Company Performance

Story-telling helps to define the human experience. Do people also use narratives to make sense of, and to act on, financial information? Three studies demonstrate that people’s investment predictions and choices instead are by narrative thinking. Whereas neoclassical financial theory maintains that past public information cannot be used to predict future prices, participants used company performance information revealed before a base price quotation to project future price trends after that quotation (Experiment 1), as though they are using affectively laden information to predict the ending of a story. Importantly, these projections were stronger when information concerned predictions about a company’s future performance rather than actual data about its past performance, suggesting that people not only rely on financially irrelevant (but narratively relevant) information for making predictions, but erroneously impose temporal order on that information. These biased predictions had downstream consequences for asset allocation choices (Experiment 2) and these choices were driven in part by affective reactions to the company performance news (Experiment 3). These results could not be explained either by expectations conforming to neoclassical financial models or by expectations informed by behavioral anomalies. The effect of expertise was modest, at least among novice investors, suggesting that these expectations may guide the beliefs of both amateur and more experienced investors. We conclude by discussing the prospects for a narrative theory of choice.
The Pathway Program: A collaboration between 3 universities to deliver a social work distance education (DL) program to underserved areas of California

This paper describes the development of a partnership between three campuses to develop a (DL) education program-serving employees of county and tribal Health and Human Service Departments in remote rural areas of California. Speciﬁcally, the program supports the development of a career pathway for students living in isolated regions of Northern California and Inland Southern California. Surveys and focus groups carried out in 2008 and 2009 identiﬁed the need for such a program. Title IVE funding (federal funding for training and education of child welfare workers) was granted via the California Social Work Education Center based at the University of California, Berkeley, which also coordinates the program. Course development, outreach, advising, and student admissions began in Chico and Humboldt in the north and San Bernardino in the south. The ﬁrst phase was considerable outreach to children’s services county agencies whose employees needed to gain a B.A.S.W. and/or M.S.W. This included academic advising and study skills training. Progress on the implementation of each program along with considerable dialogue on the elements of successful collaboration are discussed. The Pathway Program: A collaboration between 3 universities to deliver a social work distance education (DL) program to underserved areas of California
A comparison of three types of tracheal tube for use in laryngeal mask assisted blind orotracheal intubation

Laryngeal mask assisted blind orotracheal intubation is a technique that is best mastered under controlled circumstances. The influence of the type of tracheal tube, and positioning of the head, on the success rate of this procedure was evaluated in 90 gynaecological patients presenting for elective procedures under general anaesthesia. After induction, a laryngeal mask was introduced and its position was confirmed. Up to three attempts at blind orotracheal intubation using one of three tracheal tubes (Argyle, Portex or Kendall Curity) passed through the laryngeal mask were permitted in each patient. The success rates after a single attempt at blind oral intubation were 3.3%, 70.0% and 30.0% respectively (p < 0.001 and p < 0.05 when Portex was compared to Argyle and Kendall Curity types). After a maximum of three attempts, success rates were 30.0% (Argyle), 93.3% (Portex) and 76.7% (Kendall Curity). The first attempt at tracheal intubation was performed in the 'sniffing the morning air position‘ and this was successful in 52% of successful intubations; the second attempt using extension at the atlanto‐occipital joint was successful in a further 35% of successful intubations; the third attempt used varying degrees of neck flexion and extension at the atlanto‐occipital joint and this permitted successful placement of the tracheal tube in the remaining 13% of patients in whom tracheal intubation was possible.
Migrations and Growth of Deep-Sea Lobsters, Homarus americanus

In distinct contrast to the restricted movements of coastal stocks of lobsters (Homarus americanus), those inhabiting the outer continental shelf undertake extensive seasonal migrations. Of 5710 tagged lobsters released on the outer continental shelf off New England from April 1968 to June 1969, 400 had been recaptured by April 1970. The distribution of the recoveries demonstrated shoalward migration in spring and summer and a return to the edge of the shelf in fall and winter. Deep-sea lobsters have a faster rate of growth than coastal lobsters; growth increments at molting and the frequency of molting are greater.
Changes in the Learning Style and Content of Healthcare Providers in China

According to the current situation and social needs of the rapid development of science and technology, this article suggests that healthcare workers continue to pay attention to humanistic education and to use the network, multimedia and other modern teaching. More creative and joint courses are required to train medical workers master to update knowledge and clinical skills, to cultivate active innovation and logical thinking ability and advocating personalized learning styles and habits.
The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis

Advances in the understanding of leishmaniasis progression indicate that cellular interactions more complex than the Th1/Th2 paradigm define the course of infection. Th17 cells are a crucial modulator of adaptive immunity against Leishmania parasites acting mainly on neutrophil recruitment and playing a dual role at the site of infection. This review describes the roles of both these cell types in linking innate defense responses to the establishment of specific immunity. We focus on the Th17–neutrophil interaction as a crucial component of anti-Leishmania immunity, and the clinical evolution of cutaneous or visceral leishmaniasis. To date, information obtained through experimental models and patient evaluations suggests that the influence of the presence of interleukin (IL)-17 (the main cytokine produced by Th17 cells) and neutrophils during Leishmania infections is strictly dependent on the tissue (skin or liver/spleen) and parasite species. Also, the time at which neutrophils are recruited, and the persistence of IL-17 in the infection microenvironment, may also be significant. A clearer understanding of these interactions will enable better measurement of the influence of IL-17 and its regulators, and contribute to the identification of disease/resistance biomarkers.
Exploring electric vehicle participation in the Icelandic balancing market as Virtual Power Plant

The electrification of transport sector has been named as one of the key measures to mitigate the global CO2 emissions. Due to the local energy mix, Iceland has a lot of potential to effectively reduce CO2 emissions by further increasing the share of electric vehicles (EV) in their fleet. To incentivize the increased rollout, financial incentives for individual car owners need to be created. The idea is to capitalize on the fact that small vehicles are rarely moving more than 30 minutes per day. Through vehicle-to-grid (V2G) technology, the storage capacities of the EVs could be on the Icelandic balancing market for balancing when the vehicles are not in use. This research sets out to determine if it is possible for a fleet of EVs to be able to compete in the Icelandic balancing market. In order to compete, the vehicles have to be pooled and managed as single acting entity through an aggregator. All vehicles pooled by the aggregator are acting as a Virtual Power Plant (VPP). To determine the viability of the idea, this research ran an agent based simulation, modelling the mobility behavior and balancing market using Icelandic data. The results show that a VPP of EV batteries can in fact participate successfully in the balancing market. Both participating vehicle owners and the VPP operator can accumulate profits – to what extent is however highly dependent on inter alia battery costs, the electricity retail price, and the minimum bid size for participation in the balancing market.
Balancing collaboration with coordination: Contesting eradication in the Australian plant pest and disease biosecurity system

The logistical challenge of coordinating natural resource management actions across large scales is typically complicated by the diversity of stakeholders’ interests. Devising a plan is difficult. Getting diverse stakeholders to agree to and adhere to any logistical solution is harder still. Hence logistical solutions to large-scale problems involve a combination of coordination, and trust-building and contestation which are two key features of collaboration. We studied networks based on stakeholder participation in institutional responses to agricultural pest and disease incursions, where the spatial complexity of response is further challenged by the need to design and implement plans quickly in order to stop the spread of incursions. Using data from the 2010 Australian myrtle rust incursion, we used novel statistical network methods which showed that policy forums at national scales, where higher-level decisions are made, were associated with denser overlapping stakeholder interactions signifying collaboration (bondingcapital, high transaction-costs). Our qualitative data unpacked this, showing how at times uncertainty in process and information is used by some stakeholders to contest decisions at national scales. We failed to find statistical evidence that at local scales, where plans are implemented more-or-less at face value, networks exhibited lower-transaction cost interactions associated with the socially cheaper task of coordination (bridging-capital, low transaction-costs). By identifying the mix of coordination and collaboration in networks for solving environmental problems, capacity building can be more targeted, and rules-of-behaviour can be developed that better fit the requirements of the diverse tasks involved.
Stable, Germ-Line Transformation of Culex quinquefasciatus (Diptera: Culicidae)

Abstract A Hermes-based transposable element transformation system incorporating an enhanced green fluorescent protein (EGFP) marker was used to produce two transgenic lines of Culex quinquefasciatus (Say). The transformation frequency was ≈12% and transformation of Culex was shown to be dependent on the presence of Hermes transposase. Injected Culex embryos were treated with four different heat shock regimes, two of which produced transformed individuals. These individuals were mated with wild-type mosquitoes and produced offspring which expressed the dominant EGFP gene in Mendelian ratios predicted for the stable integration of a gene at a single locus. The two transformed lines displayed distinct patterns of phenotypic expression, the expression of which has remained stable after fifteen generations. In these transgenic lines both the Hermes element and flanking plasmid DNA integrated into the Culex genome, as has been previously seen in Hermes-mediated transgenic strains of Aedes aegypti (L.). The high frequency of Culex transformation together with the dependence on the presence of Hermes transposase suggests that, as for Ae. aegypti, this mode of transposition into the germ-line genome occurs by an alternate mechanism to the cut and paste type of transposition seen for this element in other insect species and in the somatic nuclei of mosquitoes. This is the first report of the genetic transformation of a species in the genus Culex and demonstrates that this medically important mosquito species can now, along with several other Culicine and Anopheline mosquito species, be genetically manipulated.