Miracle-dz/UniFAR-FTUs huggingface dataset:
Genotype, Harvest Season, and Cold Storage Influence on Fruit Quality and Antioxidant Properties of Apricot

The total antioxidant capacity, total phenols, and selected pomological traits of fresh apricots belonging to 12 genotypes were investigated over a 3-year period. These analyses were carried out on apricots at the ready-to-eat stage and after 7 and 14 days at 4°C cold storage. Total antioxidant capacity and total phenols ranged from 1.14 ± 0.10 μmolTE gFW−1 to 9.93 ± 0.73 μmolTE gFW−1 and from 0.22 ± 0.01 mgGAE gFW−1 to 1.37 ± 0.11 mgGAE gFW−1, respectively. An effect of the harvest year on the antioxidant properties was also found to be dependent on the cultivars. The most storage-susceptible parameter was the flesh firmness of fruits, while the antioxidant level was maintained during storage. The influence of the genotype on fruit quality, which involves pomological and nutraceutical properties, was highlighted by analysis of variance, hierarchical clustering, and principal component analysis.
Exploration of quantitative kinetic models for the evaporation of silicate melts in vacuum and in hydrogen

Abstract— Two basic approaches (pure component reference (PCR) and equilibrium reference (EQR)) to modeling silicate melt evaporation are explored. The PCR model calculates the maximum possible evaporation rates of the pure oxides from their equilibrium vapor pressures and rescales these rates according to the activities of the oxides in the silicate melts and the melt densities. The EQR model calculates the maximum possible evaporation rates based on the equilibrium vapor pressures of the melts. Differences between the calculated and experimentally determined evaporation rates are accounted for with evaporation (αevap) coefficients that are only dependent on temperature. Two versions of the PCR model, Cases 1 and 2, are explored to try to resolve apparently contradictory conclusions about the composition of the evaporating species based on Mg and Si isotope fractionation during evaporation (species are not in thermodynamic equilibrium proportions) and direct measurements of gas species in Langmuir experiments (species are in roughly equilibrium proportions). The Case 2 and EQR models cannot explain the observed isotope fractionations unless evaporation occurred under non‐Rayleigh conditions, either because there was significant recondensation during the experiments or because diffusion was playing a limiting role.
A protocol for systematic review and meta-analysis

Background: Limb spasms are a common complication of stroke. It not only affects the quality of life of stroke survivors, but also brings an economic burden. Tuina combined with physical therapy is widely used in the rehabilitation of poststroke spasticity. However, there is no supporting evidence for its efficacy and safety. This study aimed to evaluate the effectiveness and safety of Tuinas combined with physical therapy in the treatment of spasticity after stroke. Methods: Literature will be collected from the following databases: China Biology Medicine (CBM), Wanfang Database, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), PubMed, Embase, Cochrane Library, andWeb of Science; We will include randomized controlled trials of Tuina combined with physical therapy for poststroke spasticity range from the establishment to May 1, 2021. There were no limitations to the publication time, and the language was limited to Chinese and English. The primary outcome was evaluated using the Modified Ashworth scale, and the secondary outcomes were the simplified Fugl-Meyer Assessment scale, Modified Barthel Index, Functional Independence Measurement (FIM), and Visual Analog Scale. RevMan V.5. 4.1 software was used for the meta-analysis. The Cochrane Intervention System Evaluation Manual analyzes the risk of bias, and the recommended grading assessment, development and evaluation are used to assess the quality of evidence. Ethicsanddissemination: This study will be based on published systematic review studies, no ethical approval is required and the results of the study will be published in a peer-reviewed scientific journal. Systematic review registration: INPLASY2021110064. Abbreviations: GRADE = grading of recommendations assessment, development and evaluation, MAS = modified ashworth scale, MBI = modified barthel index, PT = physical therapy, RCTs = randomized controlled trials, SR = systematic review, SFMA = simplified fugl-meyer assessment, VAS = visual analogue scale.
Markers of renal function at admission and mortality in hip fracture patients - a single center prospective observational study

Abstract Plasma cystatin C and shrunken pore syndrome (SPS) are associated with increased mortality in older adults. The objective was to assess the association between these markers of kidney function at admission and mortality in hip fracture patients. Hip fracture patients presenting at Lund University Hospital were eligible for inclusion. Cox regression was used to assess association between plasma cystatin C, creatinine, cystatin C- or creatinine-based estimations of glomerular filtration rate (eGFRCYS and eGFRCREA), or SPS (defined as eGFRCYS/eGFRCREA < 0.7) and mortality during one year follow up. Improvement in discrimination relative to the Nottingham Hip fracture score was assessed by Receiver Operational Characteristics (ROC) analysis and calculation of Net Reclassification Index (NRI). 996 patients were included in the study. Cystatin C, creatinine, eGFRCYS and eGFRCREA were associated with one-year mortality in both unadjusted and adjusted analyses. The association with mortality was stronger for cystatin C and for eGFRCYS than for creatinine and eGFRCREA. Patients with SPS had doubled mortality compared with patients without SPS (43.7 and 20.2%, respectively, p < .001). Hazard ratio for SPS in the adjusted analysis was 1.66 (95%CI; 1.16–2.39, p = .006). None of the markers improved discrimination compared to the Nottingham Hip Fracture Score using ROC analysis whereas eGFRCYS and eGFRCREA improved NRI. Our conclusion is that plasma concentrations of creatinine or cystatin C, eGFRCYS or eGFRCREA or SPS at admission in hip fracture patients are associated with mortality when known risk factors are accounted for. Identification of high risk patients may be improved by eGFRCYS or eGFRCREA.
Cross‐talk between autophagy and sporulation in Saccharomyces cerevisiae

Unicellular organisms, like yeast, have developed mechanisms to overcome environmental stress conditions like nutrient starvation. Autophagy and sporulation are two such mechanisms employed by yeast cells. Autophagy is a well‐conserved, catabolic process that degrades excess and unwanted cytoplasmic materials and provides building blocks during starvation conditions. Thus, autophagy maintains cellular homeostasis at basal conditions and acts as a survival mechanism during stress conditions. Sporulation is an essential process that, like autophagy, is triggered due to stress conditions in yeast. It involves the formation of ascospores that protect the yeast cells during extreme conditions and germinate when the conditions are favorable. Studies show that autophagy is required for the sporulation process in yeast. However, the exact mechanism of action is not clear. Furthermore, several of the core autophagy gene knockouts do not sporulate and at what stage of sporulation they are involved is not clear. Besides, many overlapping proteins function in both sporulation and autophagy and it is unclear how the pathway‐specific roles of these proteins are determined. All these observations suggest that the two processes cross‐talk. Individually, some key features from both the processes remain to be studied with respect to the source of membrane for autophagosomes, prospore membrane (PSM) formation, and closure of the membranes. Therefore, it becomes crucial to study the cross‐talk between autophagy and sporulation. In this review, the cross‐talk between the two pathways, the common protein machineries have been discussed.
Relationship between fiducial points on the peripheral and central blood pressure waveforms: rate of rise of the central waveform is a determinant of peripheral systolic blood pressure

Central systolic blood pressure (cSBP, the peak of the central waveform) is usually regarded as the determinant of peripheral systolic blood pressure with amplification of peripheral systolic blood pressure (pSBP) measured with reference to cSBP. However, the earlier portion of the central waveform up to the first systolic shoulder (P1) may be the major determinant of pSBP. We performed in silico simulation studies and examined previously acquired experimental data (n = 131) in which peripheral and central blood pressure waveforms had been acquired both invasively and noninvasively to examine the determinants of pSBP. Measurements were made at baseline and during perturbation of hemodynamics by inotropic and vasoactive drugs. In silico simulations using a central-to-peripheral transfer function demonstrated that pSBP is dependent on P1 and the rate of change (dP/dt) of central pressure up to the time of P1 but not cSBP. In computational simulations, peripheral reflection in the radial artery was closely related to dP/dt, and 97% of the variability in amplification as measured with reference to P1 was explained by dP/dt. In vivo, amplification of pSBP over P1 was correlated with dP/dt (R > 0.75, P < 0.0001 for all data sets), and P1 and dP/dt were independently correlated with pSBP, explaining 90% of the variability in pSBP. We conclude that P1 and dP/dt are major determinants of pSBP and that pSBP and cSBP are, in part, determined by different cardiac, central, and peripheral vascular properties. NEW & NOTEWORTHY Peripheral systolic BP is determined mainly by the first shoulder and the rate of rise of the central systolic blood pressure waveform rather than the peak of this waveform (central systolic BP). Peripheral and central systolic blood pressure are determined by different cardiac and vascular properties.
Robust Optimal Control for the Vehicle Suspension System With Uncertainties

The suspension system is an important unit that affects vehicle performance, including handling stability and riding comfort. In order to improve vehicle performances, a novel robust optimal control strategy for the active suspension system in vehicles is proposed. To handle the parameter uncertainties and external random disturbances, the proposed optimal control strategy is designed by using the combination of the linear quadratic regulator (LQR) optimal control and sliding-mode control. First, by using the nominal model of the active suspension system without the uncertain parameters and the external random disturbances, an optimal control performance index is given, and the initial optimal controller is designed by using the LQR control strategy. Then, to handle the parameter uncertainties and the external disturbances, a robust optimal integral sliding-mode control strategy based on the initial optimal controller is designed, which not only can achieve the optimal control objective but also has good robustness to the uncertain parameters and external disturbances. By using the Lyapunov stability theory, stability analysis of the proposed robust optimal integral sliding-mode control strategy is performed. Finally, the collaborative simulation platform based on the Carsim and MATLAB/Simulink is developed. The simulation results illustrate the advantage of the proposed robust optimal control strategy for the suspension system.
Commentary: Does 'cry it out' really have no adverse effects on attachment? Reflections on Bilgin and Wolke (2020).

In their recent paper published in JCPP, Bilgin and Wolke (2020a) argue that leaving an infant to 'cry it out', rather than responding to the child's cries, had no adverse effects on mother-infant attachment at 18 months. This finding opposes evidence across a wide range of scientific fields. Here, we outline several concerns with the article and argue against some of the authors' strong claims, which have already gained media attention, including a report on the NHS website. We suggest that the authors' conclusions should be considered one piece of a larger scientific whole, where 'cry it out' seems, overall, to be of detriment to both attachment and development. Crucially, we are concerned that this study has issues regarding power and other analytical decisions. More generally, we fear that the authors have overstated their findings and we hope that members of the public do not alter their parenting behaviours in line with such claims without further research into this controversial topic.
Spatial mapping of soil properties in Konkan region of India experiencing anthropogenic onslaught

Soils of Indian Konkan region, part of ecologically sensitive Western Ghats have been subjected to anthropogenic activities of late. This has endangered the ecological security through conspicuous losses in topsoil quality. The rationale of the present study was to map the soil properties and create management zones for ensuring food and nutritional security. The study was conducted in South Goa district of the state of Goa located in Konkan region. A total of 258 geo-referenced soil samples were collected and analyzed for pH, EC, SOC, available N, P, K and DTPA extractable micronutrients viz., Zn, Cu, Fe and Mn. Soil pH was found to be in acidic range. A wide variability existed in SOC content ranging from 0.12–5.85%. EC was mostly neutral with mean value 0.08±0.37 dSm-1, while available nitrogen (AN), available phosphorus (AP) and available potassium (AK) varied in range from 56.4–621.6 kg ha-1, 0.5–49.7 kg ha-1 and 31.5–786.2 kg ha-1 with mean values 211.2±76.9, 8.4±8.2 and 202.3±137.6 kg ha-1, respectively. A wide range was exhibited by cationic DTPA extractable Zn, Cu, Fe and Mn with mean values, 0.22±0.30, 0.44±0.60, 7.78±5.98 and 7.86±5.86 mg kg-1, respectively. Soil pH exhibited significant positive correlation with EC, AP AK and Zn and negative correlation with Fe and Cu. SOC exhibited significantly correlated with AN, AP, AK, Zn and Fe. Geo-statistical analysis revealed J-Bessel as best fit semivariogram model for pH, AP and AK; Rational Quadratic for EC, SOC, Zn and Mn; Hole effect for AN; Stable for Cu and K-Bessel for Fe for their spatial mapping. Four principal components showed eigenvalues more than one and cumulative variability of 59.38%. Three distinct soil management zones showing significant variation in soil properties were identified and delineated for wider scale management of soils. Precision nutrient management based on spatial variation and their mapping would enable refined agricultural and environmental management practices in the region.
Genetic analysis indicates spatial-dependent patterns of sex-biased dispersal in Eurasian lynx in Finland

Conservation and management of large carnivores requires knowledge of female and male dispersal. Such information is crucial to evaluate the population’s status and thus management actions. This knowledge is challenging to obtain, often incomplete and contradictory at times. The size of the target population and the methods applied can bias the results. Also, population history and biological or environmental influences can affect dispersal on different scales within a study area. We have genotyped Eurasian lynx (180 males and 102 females, collected 2003–2017) continuously distributed in southern Finland (~23,000 km2) using 21 short tandem repeats (STR) loci and compared statistical genetic tests to infer local and sex-specific dispersal patterns within and across genetic clusters as well as geographic regions. We tested for sex-specific substructure with individual-based Bayesian assignment tests and spatial autocorrelation analyses. Differences between the sexes in genetic differentiation, relatedness, inbreeding, and diversity were analysed using population-based AMOVA, F-statistics, and assignment indices. Our results showed two different genetic clusters that were spatially structured for females but admixed for males. Similarly, spatial autocorrelation and relatedness was significantly higher in females than males. However, we found weaker sex-specific patterns for the Eurasian lynx when the data were separated in three geographical regions than when divided in the two genetic clusters. Overall, our results suggest male-biased dispersal and female philopatry for the Eurasian lynx in Southern Finland. The female genetic structuring increased from west to east within our study area. In addition, detection of male-biased dispersal was dependent on analytical methods utilized, on whether subtle underlying genetic structuring was considered or not, and the choice of population delineation. Conclusively, we suggest using multiple genetic approaches to study sex-biased dispersal in a continuously distributed species in which population delineation is difficult.
Population-based reference intervals for ferritin, iron, transferrin and transferrin saturation and prevalence of iron deficiency in 6–12-year-old children: the Health Oriented Pedagogical Project (HOPP)

Abstract Appropriate reference intervals are important for correct interpretation of laboratory test results. The primary objective of the present study was to establish pediatric reference intervals for biochemical markers essential in the assessment of iron status. As a secondary objective we calculated the prevalence of iron deficiency according to WHO recommendations. Blood samples were obtained from 1355 healthy children 6–12 years of age participating in the Health Oriented Pedagogical Project (HOPP). For our primary objective, data from 1333 children were used to establish reference intervals for ferritin, iron, transferrin and transferrin saturation. Following the CLSI C28-A3 guidelines, the 2.5th and 97.5th percentiles with corresponding 90% confidence intervals, were estimated by the nonparametric method. None of the measured analytes required partitioning for age or sex. The prevalence of iron deficiency was 8.2%, which is higher than reported in other populations.
Hematological parameters in EGFR-mutated advanced NSCLC patients treated with TKIs: predicting survival and toxicity

ABSTRACT Background: The aim of this study was to analyze the prognostic value of pre-treatment hematological parameters in EGFR-mutated non-small cell lung cancer patients treated with tyrosine-kinase inhibitors (TKIs). Patients and methods: Patients with EGFR mutations were treated with EGFR-TKIs in the first line until progression/unacceptable toxicity. Hematological parameters were derived from the absolute baseline differential counts of a complete blood count. The associations between the patients’ and tumor characteristics were analyzed using Pearson Chi-Square, Fisher’s exact, t-test, and Mann–Whitney tests. Cutoff values were determined using ROC curves, and correlation with survival was examined by Kaplan–Meier method and Cox regression. Results: Patients with NMR<12.62 had a longer PFS compared to patients with higher NMR values (12.0 vs. 10.0 months, p = 0.054) and a significantly longer OS (20.0 vs. 11.0 months, p = 0.010). The same parameter was confirmed as a predictors of favorable response in the patient subgroup with activating EGFR mutations. Patients with NLR>2.9 and LMR<2.5 more often presented with paronichia and diarrhea, and patients with PLR>190 more often had paronichia, diarrhea and hyperbilirubinemia. Conclusion: Low baseline value of the hematological parameter NMR has shown potential as a routine, low-cost, and minimally invasive predictor of survival in EGFR-TKI-treated NSCLC patients.
Qualitative and quantitative profiles of jejunal oligosaccharides and caecal short chain fatty acids in broiler chickens receiving different dietary levels of fiber, protein and exogenous enzymes.

BACKGROUND Dietary supplemental carbohydrases are able to degrade non-starch polysaccharides (NSP) and generate oligosaccharides in the gastrointestinal tract. This study was conducted to investigate the influence of dietary fiber and protein levels on growth performance, nutrient utilization, digesta oligosaccharides profile, and caecal short chain fatty acids (SCFA) profile in broilers receiving diets supplemented with xylanase or protease individually or in combination. RESULTS Enzyme supplementation had no effect on growth performance. There was significant (P < 0.05) fiber × protein × xylanase interaction for ileal nitrogen digestibility and significant (P < 0.01) protein × xylanase × protease interaction for nitrogen corrected apparent metabolizable energy (AMEn). Birds fed HF diets had higher (P < 0.05) jejunal oligosaccharide and caecal short chain fatty acids concentrations. Xylanase and protease combination produced the greatest pentose (Pent) levels in APLF diets but lowest levels in HF diets. There was significant (P < 0.05) fiber × xylanase × protease interaction explained by the digesta concentrations of (Pent)3 , (Pent)4 and (Pent)5 being greatest (P < 0.5) in protease-only-supplemented HF diets but lowest in protease-only-supplemented LF diets. CONCLUSION These results suggest that of all the factors investigated, dietary fiber level had the greatest effect on modulating digesta concentration of oligosaccharides and caecal SCFA. Evidence points to the fact that there is considerable capacity for generating pentose oligosaccharides in the digestive tract of broilers receiving diets rich in fibrous feedstuffs and that this may have beneficial effect on microbial profile in the digestive tract. This article is protected by copyright. All rights reserved.
Soft, wireless and subdermally implantable recording and neuromodulation tools

Progress in understanding neuronal interaction and circuit behavior of the central and peripheral nervous system (PNS) strongly relies on the advancement of tools that record and stimulate with high fidelity and specificity. Currently, devices used in exploratory research predominantly utilize cables or tethers to provide pathways for power supply, data communication, stimulus delivery and recording, which constrains the scope and use of such devices. In particular, the tethered connection, mechanical mismatch to surrounding soft tissues and bones frustrate the interface leading to irritation and limitation of motion of the subject, which in the case of fundamental and preclinical studies, impacts naturalistic behaviors of animals and precludes the use in experiments involving social interaction and ethologically relevant three-dimensional environments, limiting the use of current tools to mostly rodents and exclude species such as birds and fish. This review explores the current state-of-the-art in wireless, subdermally implantable tools that quantitively expand capabilities in analysis and perturbation of the central and PNS by removing tethers and externalized features of implantable neuromodulation and recording tools. Specifically, the review explores power harvesting strategies, wireless communication schemes, and soft materials and mechanics that enable the creation of such devices and discuss their capabilities in the context of freely-behaving subjects. Highlights of this class of devices includes wireless battery-free and fully implantable operation with capabilities in cell specific recording, multimodal neural stimulation and electrical, optogenetic and pharmacological neuromodulation capabilities. We conclude with a discussion on translation of such technologies, which promises routes towards broad dissemination.