Miracle-dz/UniFAR-FTUs huggingface dataset:
Cyclobenzaprine for acute back pain.

How effective is cyclobenzaprine for acute back pain? Cyclobenzaprine reduces pain and leads to global improvement compared with placebo for 1 in every 3 to 9 patients in the first week. Cyclobenzaprine generally adds little to naproxen. Taken 3 times daily, 5 mg is as effective as 10 mg, with less
orrent or Torment rom the Tubules ? * hallenge of the ardiorenal Connections

he increasing use of angiotensin-converting enzyme inibitors and beta-blockers has delayed the progression of nd decreased mortality in heart failure. As more patients urvive into advanced stages of disease, however, it is ncreasingly difficult to maintain optimal fluid balance while reserving renal function. The complexity of cardiorenal onnections was the subject of recent review by a working roup of the National Heart, Lung, and Blood Institute (1). he current study by Paterna et al. (2) in this issue of the ournal suggests surprising efficacy of a strategy to enhance oth acute and chronic diuretic response by enhanced odium intake. This counterintuitive approach underlines he need for better understanding of factors that regulate odium and water handling in chronic heart failure.
Regression rules extraction from artificial neural network based on least squares

As an intelligent approach, the artificial neural network (ANN) has been shown to exhibit superior predictive power compared to traditional approaches in many studies. However, its further development is restricted by its characteristic of “black box” because it can't explain how learning from input data was done and how performance can be consistently ensured. In order to open the “black box”, a novel approach of regression rules extraction from ANN based on Least Squares is proposed in this paper, it can uncover underlying dependencies between the input data and the output data of ANN. Its main concepts are that the nonlinear activation function of each hidden unit is approximated locally by a three-piece linear function based on Least Squares and then the regression rules are generated by decision tree approach. The piecewise linear regression rules can not only ensure the accuracy but also enhance the explanation. Experiments on two public datasets show that the proposed approach generates rules are more accurate than the existing approaches based on decision trees or linear regression.
An IoT Application for Inventory Management with a Self-Adaptive Decision Model

Safety storage in large warehouse is an urgent issue to be addressed by both the local authorities and businesses, especially after the Tianjin explosions. This paper proposes an inventory management system for a warehousing company. The system integrates RFID technology and a self-Adaptive distributed decision support model for inbound and outbound actives, inventory location suggestions and incident handling. The model consists of three major components: environment recognition, knowledge merging and the decision making. In addition, a 'self-adaptive' feature is adopted for adjusting the knowledge used in decision making procedure. An experiment is also outlined to validate the utilisations of our model and the proposed system.
Gegen den ökonomischen Mainstream. Über: Kate Raworth. Die Donut-Ökonomie: Endlich ein Wirtschaftsmodell, das den Planeten nicht zerstört

Das viel beachtete Buch zur Donutökonomie von Kate Raworth, das sieben nach Ansicht der Verfasserin zu überwindende Charakteristika des ökonomischen Mainstreams und sieben alternative Charakteristika aus Sicht der weltweiten Bewegung der pluralen Ökonomie enthält, wird vorgestellt und kritisch diskutiert.
Development and psychometric testing of the Leddy Healthiness Scale.

The study was designed to develop and determine the psychometric properties of the Leddy Healthiness Scale (LHS). Healthiness is defined as having perceived purpose and the power to achieve goals. In three stages, using three overlapping samples, internal consistency reliability ranged from . 89 to . 93. Test-retest reliability was . 86 at 2-6 weeks. Principal components factor analysis revealed three components which explained 51.2% of the instrument variance. Convergent validity was supported by strong correlations between the LHS and the Sense of Coherence Scale (r = .72), a one-term measure of overall well-being (r = .62), the Perceived Well-Being Scale (r = .74), the Power As Knowing Participation in Change Test (r = .63), and the Personal Meaning Index (r = .62). Divergent validity was supported by a moderate negative correlation between the LHS and the Fatigue Experience Scale (r = -.41). It was concluded that the LHS has demonstrated initial reliability and validity. Further testing is recommended.
Knowledge discovery in the legal domain

Whilst cases have been regularly used in building legal case based reasoners, they have rarely been used as a means of automated discovery of legal knowledge. Significant obstacles must be overcome if knowledge discovery techniques are to be applied in the legal domain. We argue that the use of domain expertise is vital and that an abundance of commonplace cases is necessary. Even with appropriate data, knowledge discovery techniques in law must deal with contradictory cases and use statistical techniques in order to define error and estimate performance. We illustrate these points by describing the use of the cross validation resampling technique, our own error heuristic and the method we use for dealing with contradictions for the training of neural networks in the domain of property proceedings in Australian Family Law.
Cost of prescribed NSAID-related gastrointestinal adverse events in elderly patients.

AIMS It is well established that nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal (GI) side-effects. However, the cost of health care resources spent on preventing and managing these side-effects is not clear. The objective of this study was to estimate the direct cost of NSAID-related GI events in an elderly population. METHODS From the Régie de l'assurance-maladie du Québec (RAMQ) database, we obtained medical, pharmaceutical and demographic records of a 10% random sample (n = 49 033) of seniors who, between January 1, 1993 and December 31, 1997, had a dispensed prescription of a NSAID. Patients who did not have any GI events during the year prior to their first dispensed prescription were included in the cohort. All patients were followed-up for 2 years. The daily direct Canadian dollar costs of GI events that were incurred by these patients while they were on NSAID therapy were compared with those of GI events that were incurred by these same patients while they were not on NSAID therapy. The difference in these daily costs was attributed to NSAIDs. RESULTS A total of 12 082 new NSAID users were included in the study. Two hundred and seventeen (1.8%) were hospitalized for GI-related problems; of these, 130 (60%) had their GI hospitalization as their first GI event; 3257 (27.0%) used gastroprotective agents (GPAs), and 857 (26.3%) took GPAs without any apparent prior GI symptoms; 801 (6.6%) had GI diagnostic tests; and 661 (5.5%) died. The average direct costs of GI side-effects per patient-day on NSAIDs were 3.5 times higher than those of a patient-day not on NSAIDs. The direct cost of GI side-effects per patient-day on NSAIDs was $1.34, of which more than 70% ($0.94) was attributed to GI events resulting from NSAID treatment. CONCLUSIONS Approximately one Canadian dollar was added to patient costs for every day he/she was on NSAID therapy. Safer therapies and appropriate patient risk management may potentially reduce NSAID-related health care resource use.
High Altitude Pulmonary Edema: Hemodynamic Aspects

Over 30 years ago hemodynamic studies on patients with high altitude pulmonary edema (HAPE) excluded the prior contention that the basic cause was left ventricular failure and correctly implicated the pulmonary circulation as the culprit. Physiological studies during the acute stage have revealed a normal pulmonary artery wedge pressure, marked elevation of pulmonary artery pressure, severe arterial unsaturation, and usually a low cardiac output. Pulmonary arteriolar (pre-capillary) resistance was elevated. A working hypothesis of the etiology of HAPE suggests that hypoxic pulmonary vasoconstriction is extensive but not uniform. The result is overperfusion of the remaining patent vessels with transmission of the high pulmonary artery pressure to capillaries. Dilatation of the capillaries and high flow results in capillary injury with leakage of protein and red cells into the alveoli. While hypoxic vasoconstriction appears to be the major cause of patchy vascular obstruction the occurrence of thrombi in the pulmonary vessels may also play a role in more severe and advanced cases. The above concept of the mechanism of HAPE has been further supported by animal studies showing pulmonary edema occurring when increased pressure and flow is produced in a portion of the pulmonary vascular bed. Clinical studies which have supported this concept include the susceptibility to HAPE of patients with an absent pulmonary artery, pulmonary edema occurring in pulmonary embolism, following removal of pulmonary arterial thrombi and following balloon dilatation of stenoses of branches of the pulmonary artery. In addition to those hemodynamic factors an increase in capillary permeability due to cell derived products resulting from capillary wall injury is an important aspect of edema formation.
Studies on the role of polymorphonuclear leukocytes in neoplastic disease with the chick embryo and Walker carcinosarcoma 256 in vivo and in vitro.

Summary The role of the polymorphonuclear leukocyte (PMN) in neoplastic disease has received limited study, despite frequent observation of PMN within both clinical and experimental neoplasms. It was noted that the Pgh. 63–79 tissue culture line of Walker Carcinosarcoma 256, when grown on the chorioallantoic membrane of the chick embryo, consistently had a large PMN infiltrate within the lesion produced. This experimental system therefore was used in this investigation to determine the role of the PMN as a host defense against growth and invasion of neoplastic cells. It was found that PMN were not the primary defense of the host in this system, but were involved after the process of cell degeneration had been initiated by other mechanisms. The PMN then perpetuated this process by taking material into phagocytic vacuoles, digesting it, subsequently dying, and releasing enzymes into the environment. Techniques for in vitro isolation and observation of PMN and tumor cell interaction on coverslips were devised. With these methods, previously undescribed contact phenomena between PMN and tumor cells were observed. These included indentation of the tumor cell membrane by PMN, attraction between these 2 cell types, and rounding of the tumor cell following repeated contact with PMN.
Evaluation of a New Anaerobic Power Testing System

The purpose of this study was to evaluate the reliability of a new anaerobic athletic performance system. This system is proposed to assess vertical jump height, anaerobic power through repetitive jumping, and reaction to both an auditory and visual stimulus. One hundred twenty-three subjects (92 men and 31 women; mean ± SD: age, 20.5 ± 2.1 years; body weight, 83.1 ± 20.4 kg; height, 176.0 ± 9.2 cm) volunteered to participate. To assess reliability of the new testing device, subjects were tested on 3 separate occasions (T1, T2, and T3). At least 72 hours but not more than 1 week separated each laboratory visit. During each testing session subjects performed a countermovement jump (CMJ), a 30 consecutive jumps anaerobic power test (30JT), and reaction to both an auditory and visual stimulus. Results showed no differences between T1, T2, and T3 in either CMJ height or 30JT assessments. However, reaction to an audible or visual stimulus significantly improved during each testing session. Intraclass reliability of the CMJ and the 30JT was greater than 0.96 across the 3 trials. Pearson correlation coefficients of r > 0.90 were seen for the CMJ and 30JT, indicating a high test-retest reliability. The test-retest reliability for the reaction tests were lower (r ranging from 0.72 to 0.83). A Bland-Altman plot showed limited agreement between methods of vertical jump height assessment. Results indicate that this new testing device shows high reliability to assess both CMJ height and anaerobic power. In addition, anaerobic power assessment in a jump test provides a specific measure of anaerobic power for many sports incorporating similar performance patterns.
Factores asociados al estilo de vida en pacientes diagnosticados con cáncer colorrectal en un Hospital de Chile

Antecedentes: el cancer es la segunda causa de muerte a nivel mundial, siendo uno de los mas prevalentes el cancer colorrectal. Diversos autores concluyen que un estilo de vida saludable previene en un 30 a 40 % el desarrollo de cualquier tipo de cancer. Objetivo: evaluar retrospectivamente la ingesta de vitaminas C, E, fibra dietetica, frutas, verduras, grasas saturadas, nivel de actividad fisica, sedentarismo, consumo de tabaco y alcohol en sujetos diagnosticados con cancer colorrectal. Materiales y metodos: estudio descriptivo retrospectivo en 22 pacientes. Se aplicaron como instrumentos la encuesta de tendencia de consumo cuantificada, el cuestionario mundial sobre actividad fisica y la encuesta estructurada de caracterizacion. Resultados: el consumo de vitamina C fue de 131,8 mg/dia; y de vitamina E, de 34,8 mg/dia sobrepasando la recomendacion diaria admisible (p<0,05). La ingesta de fibra dietetica (8,6 g/dia) fue menor a la recomendacion (p<0,001). La actividad fisica moderada e intensa fue de 418 y 475 min/sem respectivamente, ambas mayores a la recomendacion (p=0,029, p=0,015). Conclusion: una ingesta deficiente de fibra y verduras podria estar relacionada con la oncogenesis colorrectal.
MEM pixel correlated solutions for generalized moment and interpolation problems

We propose a new family of solutions for the classical generalized moment problem and the interpolation problem. The maximum entropy method on the mean (MEM) construction is the limit of the mean of some random discretized measure, where the amplitudes between pixels have a dependence structure. The method may be interpreted as a Bayesian procedure. Linear transfer allows one to introduce new prior information such as: modality, convexity, Sobolev norms. We also present MEM for exchangeable amplitudes on the pixels.
Pharmacological Evidence for the Involvement of Calcium Entry through TRPV1 Channels in Nifedipine-Induced [Ca2+]i Elevation in Gingival Fibroblasts

Background: Among anti-hypertension drugs, calcium (Ca2+) antagonists cause gingival overgrowth as a side effect. We previously discovered that this side effect was due to elevation of the calcium concentration in the cytosol ([Ca2+]i). Ca2+ entry through non-selective cation channels (NSCCs) and Ca2+ release from intracellular Ca2+ stores are involved in this [Ca2+]i elevation. Furthermore, we discovered that calcium-sensing receptors (CaSRs) participate in nifedipine-induced [Ca2+]i elevation. Transient receptor potential (TRP) channels have been identified as NSCCs. In the present study, we undertook experiments to determine if TRPV1 channels are present in gingival fibroblasts and to ascertain if nifedipine-activated NSCCs are TRPV1 channels. Methods Normal human gingival fibroblast Gin-1 cells were used. The [Ca2+]i was measured using a video-imaging analysis system with the Ca2+-sensitive fluorescent dye fura-2/AM. Results: The NSCC inhibitor SKF96365 significantly inhibited nifedipine-induced [Ca2+]i elevation. TRPV1 channel agonists such as capsaicin, olvanil and resiniferatoxin concentration-dependently elevated the [Ca2+]i. The TRPV1 channel activator anandamide concentration-dependently increased the [Ca2+]i. The TRPV1 channel antagonists capsazepine, AMG9810, iodoresiniferatoxin, ruthenium red, and SB366791 significantly inhibited nifedipine-induced [Ca2+]i elevation. Conclusion: These results suggest that Ca2+ entry through TRPV1 channels is involved in the nifedipine-induced [Ca2+]i elevation seen in gingival fibroblasts. We describe here a modified version of our ‘calcium trigger theory’.
KESINAMBUNGAN DAN PERUBAHAN LEMBAGA PENDIDIKAN DI PONDOK PESANTREN DARUL ULUM JOMBANG

Penelitian ini mengkaji tentang kesinambungan dan perubahan lembaga pendidikan di Pondok Pesantren. Sejarah pendidikan Islam di Indonesia menunjukkan bahwapondok pesantren dikenal luas memiliki peran signifikan, khususnya dalam dimensi pendidikan masyarakat (santri). Dalam perkembangannya di tengah-tengah arus perubahan jaman, pesantren ternyata mampu beradaptasi demi keberlangsungan eksistensinya. Kesinambungan dan perubahan lembaga pendidikan Islam ini tidak lepas dari peran kiai dalam melakukan konstruksi sosial terhadap perubahan yang ada di luar pondok pesantren. Penelitian ini menggunakan metode kualitatif. Dalam pengumpulan data dilakukan dengan tiga cara, yaitu observasi,wawancara, dan dokumen. Pengumpulan data dilakukan sekitar 4 bulan. Informan dalam penelitian ini adalah para kiai pengasuh pondok pesantren Darul Ulum sebanyak 7 orang, yang memiliki peran penting dalam menentukan arah perubahan pondok pesantren. Lokasi penelitian ini adalah Pondok Pesantren Darul Ulum Rejoso Peterongan Jombang. Hasil penelitian menunjukkan bahwa perkembangan lembaga pendidikan di pondok pesantren Darul Ulum, telah mengalami dinamika kesinambungan dan perubahan pada masa kepemimpinan Kiai Musta‟in Romli. Tareqat Qodiriyah wa Naqsabandiyah sebagai amaliyah yang berbasis nilai- nilai sufistik, masih tetap berkembang di tengah arus perubahan. Tareqat yang merupakan cikal bakal berdirinya lembaga pendidikan di pondok pesantren Darul Ulum jusrtu berjalan seiring dengan perubahan dan tetap terus bertahan hingga saat ini. Namun tidak dipungkiri dalam proses dinamika perkembangan tersebut, pondok pesantren Darul Ulum juga mengalami perubahan, khususnya lembaga pendidikan. Lembaga pendidikan yang awal berdirinya hanya mengajarkan ilmu agama Islam saja, kini telah mengalami perubahan orientasi dalam bidang kurikulum dan menejemen pendidikan. Implementasi dari perubahan tersebut adalah munculnya beberapa variasi lembaga pendidikan, yaitu 16 unit lembaga pendidikan.Kesinambungan dan perubahan itu tidak lepas dari peran kiai dalam melakukan konstruksi sosial untuk beradaptasi dengan perubahan yang ada di luar pondok pesantren. Perbedaan latar belakang dan pengalaman kiai-kiai sangat mempengaruhi arah dan bentuk perubahan lembaga pendidikan di pondok pesantren Darul Ulum saat ini.
Phyllodes tumours of the breast: a clinicopathological review of thirty‐two cases

We have reviewed the histological features and clinical outcome in 32 women with phyllodes tumours of the breast diagnosed in Nottingham between 1975 and 1990. We assessed 23 tumours as histologically benign, four as borderline and five as malignant. After clinical follow up for periods ranging from 36 months to 221 months (median 135 months), six of 23 benign tumours have recurred locally; in all these cases the original tumours had been incompletely excised. There were no recurrences amongst 10 benign tumours in which excision had been complete. Benign tumours which recurred showed a tendency to greater stromal cellularity and more pronounced stromal overgrowth than incompletely excised lesions which did not recur, but these differences were not statistically significant. The recurrent tumours resembled the respective original lesions histologically, except in one case in which two local recurrences were histologically malignant. The recurrent tumours were controlled by further excision or mastectomy in all cases and none have metastasized. All four borderline tumours were completely excised at initial surgery and none have recurred or metastasized. One of the five malignant tumours recurred within two months of incomplete excision, with widespread infiltration of the chest wall, although the patient died of unrelated causes. The other four malignant tumours have not recurred. We conclude that presence of tumour at the margins of the excised specimen is the major determinant of local recurrence in phyllodes tumours and that the histological features are of secondary importance. These findings are discussed in relation to other published series in the literature.
Overcoming the reliability limitation in the ultimately scaled DRAM using silicon migration technique by hydrogen annealing

We demonstrated a highly reliable buried-gate saddle-fin cell-transistor (cell-TR) using silicon migration technique of hydrogen (H2) annealing after a dry etch to form the saddle-fin in a fully integrated 2y-nm 4Gb DRAM. It clearly shows a reduction in interface trap density with highly enhanced variable-retention-time (VRT) and Row-Hammering immunity.
Discontinuous innovations framework: A review of automatic external defibrillators in the healthcare industry

Discontinuous technological innovations are important for continual market domination and new/emerging market creation. Discontinuous innovations, either radical or disruptive, tend to enter the market through high performance, low cost or unique product attributes. However, the Automated External Defibrillators in Healthcare Industry has shown that this is not necessarily so and new mode of entry via the mainstream is feasible.
Internal Pair Production of 90Y Permits Hepatic Localization of Microspheres Using Routine PET: Proof of Concept

Radioembolization with 90Y microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of 90Y glass microspheres. Methods: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient underwent PET/CT at 4 d after 90Y implantation. Patients were followed for adverse events. Results: Standard PET/CT enabled the localization of 90Y glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. Conclusion: Standard PET/CT may be used to assess the localization of 90Y glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution.