Miracle-dz/UniFAR-FTUs huggingface dataset:
Examining the association between maternal atopy and birth outcomes using a retrospective cohort in the southeastern region of the USA

Objective To assess birth outcomes in primiparous women with diagnosis of non-asthmatic atopy (NAA). Researchers hypothesised that women with NAA would have reduced the risk of adverse birth outcomes compared with women without NAA. NAA is defined as having allergic rhinitis and/or atopic dermatitis. Setting Women were mostly treated in primary care settings in South Carolina, USA. Participants This is a retrospective cohort study in which participants were identified using a Medicaid database. Participants were primiparous women aged 19 to 25. Births occurring between 2004 and 2014 were identified using the South Carolina’s Vital Statistics (VS) records of live births. Incomplete records (ie, information on plural birth, gestational age at birth or birth weight missing), plural births or infants born before completing 24 weeks of gestation were excluded. This provided 65 650 complete maternal–infant dyads, representing 97.6% of the maternal records and 96.9% of the VS records. Women previously diagnosed with NAA were frequency matched 1:4 to non–atopic controls for a total of 9965 maternal–infant dyads used in the statistical analysis. Primary outcome measures Low birth weight, small for gestational age and preterm birth. Results Linear tests for trend were statistically significant (p<0.001), indicating that NAA was associated with improved birth weight and gestational age at birth. After controlling for potential confounders, mothers with NAA had equal risk for each outcome when compared with mothers with no diagnosis of NAA. Conclusion A diagnosis of NAA among women living in the southeastern region of the USA does not reduce the risk of adverse birth outcomes nor does it elevate the risk of same. Additional studies with more rigorous designs are warranted to confirm the findings in this study.
Crystal Structure of the Extracellular Segment of Integrin αVβ3

Integrins are αβ heterodimeric receptors that mediate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the crystal structure of the extracellular portion of integrin αVβ3 at 3.1 Å resolution. Its 12 domains assemble into an ovoid “head” and two “tails. ” In the crystal, αVβ3 is severely bent at a defined region in its tails, reflecting an unusual flexibility that may be linked to integrin regulation. The main inter-subunit interface lies within the head, between a seven-bladed β-propeller from αV and an A domain from β3, and bears a striking resemblance to the Gα/Gβ interface in G proteins. A metal ion–dependent adhesion site (MIDAS) in the βA domain is positioned to participate in a ligand-binding interface formed of loops from the propeller and βA domains. MIDAS lies adjacent to a calcium-binding site with a potential regulatory function.
Uso del modelo TPACK como herramienta de innovación para el proceso de enseñanza-aprendizaje en matemáticas

Esta investigacion analiza el impacto del modelo TPACK durante el diseno de la Unidad Didactica Logica de Predicados considerando el uso del software Raptor, los videos YouTube y la red social Facebook. La muestra esta compuesta por 49 estudiantes de la Licenciatura en Gestion de Negocios y Tecnologias de Informacion que cursaron la asignatura Matematicas Computacionales en la Universidad La Salle, Campus Ciudad de Mexico durante los ciclos escolares 2014 y 2016. Por medio del metodo ANOVA se evalua el rendimiento academico del grupo experimental (20 alumnos) y grupo control (29 alumnos). Los resultados obtenidos permiten afirmar que el modelo TPACK representa una alternativa para mejorar el proceso educativo a traves de los conocimientos tecnologicos, disciplinares y pedagogicos.
Parental Schemata in the Management of Children With Attention Deficit–Hyperactivity Disorder

The authors describe the management schemata held by parents of children diagnosed with attention deficit–hyperactivity disorder (ADHD). They conducted semistructured interviews with 10 mothers of children who had ADHD and used interpretative, phenomenoogical analysis on the interview transcriptions to identify the schemata that guided the parents’ management practices. The predominant schemata were the perceived difference of children with ADHD, parental aspirations, the necessity of medication, psychological management, parental authority, role of the father, mothering concept, and community support. The authors discuss these schemata in the context of the current controversy as to whether ADHDis best regarded as a medical or a developmental disorder. They conclude that the parents’ schemata conformed to current child-raising theory, but as a consequence, the parents might not consider social factors involved in the development of ADHD sufficiently. The authors suggest that this restricted perspective limits the parents’ options for managing the condition.
REPRESENTAÇÕES SOCIAIS DA LUDICIDADE ELABORADA POR PROFESSORES

O presente estudo teve como objetivo principal identificar o nucleo central das representacoes sociais ludicidade construidas por professores das creches, da educacao infantil e do ensino fundamental ligado a rede publica e privada do municipio de Coremas/PB. A teoria das representacoes sociais serviu como aporte teorico e metodologico, tendo como referencial teorico Serge Moscovici e Denise Jodelet e Abric. A amostra desta pesquisa foi formada por 64 professores docentes com idades de 18 e 54 anos, a maioria do sexo feminino (86%) e 26% possuem pos-graduacao. Os integrantes da amostra responderam a um questionario socio demografico e a tecnica de associacao livre de palavras, cujos estimulos indutores foram “ ludicidade ”, “ educacao infantil” , “como poder trabalhado a ludicidade em sala de aula”. Os dados provenientes da associacao livre foram processados e analisados por dois softwares Tri-Deux-Mots e IRAMUTEQ. Os resultados obtidos evidenciaram que as representacoes sociais elaboradas pelos professores ancoraram a “ ludicidade ” como: «ensinar, diversao, brinquedos, jogos e alegria», a “ educacao infantil” como: «descobertas, alegria, socializacao, conhecimento» e o estimulo no seu cotidiano como trabalha a ludicidade em sala de aula como: «carinho, abraco, dinâmica, ludico». Diante da riqueza de significados existentes acerca da ludicidade, essas representacoes resultam e refletem as experiencias e caracteristicas do grupo pesquisado. Vale ressaltar que a importância da ludicidade deve ser mais bem compreendida pelos professores, pois estes profissionais sao os mediadores entre a crianca e o brinquedo, brincadeira ou jogos, e que quando a ludicidade e usada pedagogicamente, ela tem um valor ainda maior na aprendizagem das criancas.
Respiratory and Brain Ependymal Ciliary Function

The aims of this study were to compare beat frequencies of tracheal and ependymal cilia and the beat frequencies of ependymal cilia from infant and adult rats. The length of respiratory and ependymal cilia of infant and adult rats was also compared. We have developed an ex vivo model that allows ependymal and respiratory ciliary beat frequency to be measured with a high-speed video system. The beat frequencies of cilia, incubated at 37°C, were measured after an incubation period of 30 min. Ependymal cilia beat at a similar frequency in 10- to 15-d-old rats (mean 38.8 Hz: 95% confidence intervals 37.1–40.6) as in adult animals (mean 40.7 Hz: 95% confidence intervals 38.5–42.9). However, respiratory cilia from adult animals beat (mean 20.9 Hz: 95% confidence intervals 14–27) at a significantly (p= 0.003) lower frequency than ependymal cilia. Ependymal cilia (mean length ± SD: 8.2 ± 0.3 μm) measured by scanning electron microscopy were significantly (p= 0.001) longer than respiratory cilia (5.5 ± 0.6 μm) from the trachea of 9- to 15-d-old rats. Cilia did not grow longer between the time the rats were 9–15 d old and adulthood. Adult respiratory and ependymal ciliary length (mean ± SD) were 5.6 ± 0.5 μm and 8.1 ± 0.2 μm, respectively. In summary, ependymal cilia beat at approximately twice the rate of respiratory cilia and are significantly longer.
Bowen's disease treated by carbon dioxide laser. A series of 44 patients

Background: Bowen's disease is a common form of intraepidermal (in situ) squamous cell carcinoma of the skin and mucous membrane. Treatment with destruction of the epidermis by any method is necessary to prevent invasive squamous cell carcinoma. Objective: To report our experience with CO2 laser vaporization in the treatment of Bowen's disease and try to identify which factors could have any influence on results. Methods: A total of 44 patients were treated with the CO2 laser in superpulsed mode, focalized at 2 W/cm2. Results: In 86.3% of patients, a unique treatment session was required. ‘Clearance after one treatment’ was achieved in 86.3% of the total series of patients and only 7.9% of these patients developed recurrence of the lesion. In 11.3% of the cases, there was ‘clearance after more than one treatment’ without clinical recurrences in any of these patients during the follow‐up. ‘No response’ was achieved in 2.2% of the total series of patients. Conclusion: We conclude that the CO2 laser in superpulsed mode is an effective, efficient, safe, functional and good cosmetics treatment for Bowen's disease and it provides the same recurrence rate as other more aggressive or more expensive modalities of treatment.
Selecting an object-oriented process for student analysts

Object-oriented (OO) concepts can be challenging for the novice. Student analysts typically have no background in information technology (IT) and lack the experience on which to build their system models. OO analysis and design (OOA&D) is also difficult where no OO programming experience exists. The Unified Modelling Language (UML) supplies a standard notation for modelling OO systems but does not specify a methodology for integrating those models to assist in system development. This paper describes the selection of an OO process for novice analysts that integrates the UML notation and provides a foundation for future specialised OO papers. It was selected to reinforce the concept of objects collaborating to solve problems.
Multi-agent systems inspired by artificial chemistries: a case study in automated theorem proving

We investigate a new architecture for multi-agent systems inspired by artificial chemistries. In this model a huge number of autonomous entities interact in parallel. The system is demonstrated with an automated theorem prover. Our results show that it is advantageous to set up a problem as a multi-agent system based on artificial chemistries.
Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury.

Pacific salmon exposed to sublethal concentrations of organophosphate pesticides (OP) have impaired olfactory function that can lead to loss of behaviors that are essential for survival. These exposures often involve mixtures and can occur at levels below those which inhibit acetylcholinesterase (AChE). In this study, juvenile Coho salmon were exposed for 24 h to either 0.1, 0.5, or 2.5 ppb chlorpyrifos (CPF), 2, 10, or 50 ppb malathion (MAL), or binary mixtures of 0.1 CPF:2 ppb MAL, 0.5 CPF:10 ppb MAL, or 2.5 CPF:10 ppb MAL to mimic single and binary environmental exposures. Microarray analysis of olfactory rosettes from pesticide-exposed salmon revealed differentially expressed genes involved in nervous system function and signaling, aryl hydrocarbon receptor signaling, xenobiotic metabolism, and mitochondrial dysfunction. Coho exposed to OP mixtures exhibited a more pronounced loss in detection of a predatory olfactory cue relative to those exposed to single compounds, whereas respirometry experiments demonstrated that exposure to OPs, individually and in mixtures, reduced maximum respiratory capacity of olfactory rosette mitochondria. The observed molecular, biochemical, and behavioral effects occurred largely in the absence of effects on brain AChE. In summary, our results provide new insights associated with the sublethal neurotoxic effects of OP mixtures relevant to environmental exposures involving molecular and cellular pathways of injury to the salmon olfactory system that underlie neurobehavioral injury.
The cause of endomyocardial fibrosis in Uganda

Summary The cause of endomyocardial fibrosis in Uganda remains unknown in spite of studies dating back to 1948. Herbal decoctions have been used by traditional healers for countless generations to treat many complaints, especially fever. We present evidence – ethnic, geographical, tribal, pathological and distribution by age – that the toxic herbal decoctions taken as medicines in Uganda can cause endomyocardial fibrosis.
Perceived Stress After Acute Myocardial Infarction: A Comparison Between Young and Middle-Aged Women Versus Men

Objective The aim of the study was to examine how psychological stress changes over time in young and middle-aged patients after experiencing an acute myocardial infarction (AMI) and whether these changes differ between men and women. Methods We analyzed data obtained from 2358 women and 1151 men aged 18 to 55 years hospitalized for AMI. Psychological stress was measured using the 14-item Perceived Stress Scale (PSS-14) at initial hospitalization and at 1 month and 12 months after AMI. We used linear mixed-effects models to examine changes in PSS-14 scores over time and sex differences in these changes, while adjusting for patient characteristics and accounting for correlation among repeated observations within patients. Results Overall, patients' perceived stress decreased over time, especially during the first month after AMI. Women had higher levels of perceived stress than men throughout the 12-month period (difference in PSS-14 score = 3.63, 95% confidence interval = 3.08 to 4.18, p < .001), but they did not differ in how stress changed over time. Adjustment for patient characteristics did not alter the overall pattern of sex difference in changes of perceived stress over time other than attenuating the magnitude of sex difference in PSS-14 score (difference between women and men = 1.74, 95% confidence interval = 1.32 to 2.16, p < .001). The magnitude of sex differences in perceived stress was similar in patients with versus without post-AMI angina, even though patients with angina experienced less improvement in PSS-14 score than those without angina. Conclusions In young and middle-aged patients with AMI, women reported higher levels of perceived stress than men throughout the first 12 months of recovery. However, women and men had a similar pattern in how perceived stress changed over time.
Applications of the cross-layer paradigm for improving the performance of WiMax [Accepted from Open Call]

IEEE 802.16 WiMAX is anticipated to operate across diverse and formidable circumstances under stringent performance requirements such as reduced delay, jitter, and dropped packets while providing high network utilization. As a potential remedy to alleviate these performance challenges, cross-layer design and optimization beyond layered architecture have been envisioned as in many similar communication systems. In this article some recent cross-layer design and solutions for improving the performance of IEEE 802.16 WiMAX are described. Moreover, a novel routing-scheduling scheme to illustrate the application and realization of the cross-layer paradigm in this domain is presented.
Mekanik Boyun Ağrısı Olan Bireylerde, Skapular Retraksiyon Egzersizlerinin Ağrı, Yaşam Kalitesi ve Skapular Kinematiğe Etkisi

Bu calismanin amaci; mekanik boyun agrisi olan bireylerde uygulanan iki farkli fizyoterapi programinin karsilastirilmasi ve skapular bolgeyi de icine alan kombine egzersiz yaklasimlarinin etkinliginin saptanmasidir. Calismaya kronik mekanik boyun agrisi teshisi konan 23 hasta dahil edildi. Hastalarin calisma oncesinde agri durumlari gorsel analog skalasi, yasam kalitesi Boyun Ozur Anketi ve skapular kinematik verileri elektromagnetik sistem ile 30-60-90-120 derece kol elevasyonlarinda kaydedildi. Rastgele 2 gruba ayrilan ve 6 hafta takip yapilan hastalardan; grup 1'e servikal bolge mobilizasyonu ve servikal bolge egzersizleri verilirken, grup 2'ye servikal bolge mobilizasyonu, servikal bolge egzersizleri ve skapular stabilizasyon egzersizleri verildi. Tedavi boyunca haftalik agri degisimleri kaydedildi ve tedavi sonunda Boyun Ozur Anketi ve skapular kinematik verileri tekrar olculdu. Elde edilen veriler nonparametrik test kullanilarak analiz edildi. Tedavi sonucunda her iki tedavi grubun da agri ve Boyun Ozurluluk Anketi skorlarinda tedavi oncesine gore anlamli gelisme gosterdi (p 0.05). Elektromagnetik sistem sonuclarinin tedavi oncesi ve sonrasi karsilastirmalarinda grup 2'de 600-900 kol elevasyonlarinda skapular yukari dogru rotasyonda ve 1200 kol elevasyonu esnasinda posterior tilt hareketlerinde istatistiksel olarak anlamli artis bulundu (p<0.05). Grup 1'de ise 900 kol elevasyonu esnasinda yukari dogru rotasyon hareketinde anlamli artis saptandi (p<0.05). Tedavi sonunda gruplar birbirleri ile karsilastirildiklarinda posterior tilt hareketinin grup 2'de daha iyi gelisme gosterdigi saptandi (p<0.05). Calisma sonucunda boyun agrisi olan bireylere uygulanan servikal ve skapular odakli tedavi programlari agri ve yasam kalitesi yonunden birbirine benzer sonuclar gosterdi. Elektromagnetik sistem sonuclarina bakildigi zaman ise grup 2'de skapular kinematigin, grup 1'e gore daha iyi gelisme gosterdigi tespit edildi. Grup 2'de meydana gelen normal skapular kinematik yonundeki bu gelisimin boyun agrisinin tekrar gorulme riskini azaltabilecegi dusunulmektedir. Bu nedenle boyun agrisi olan bireylerde skapular stabilizasyon egzersizleri de tedaviye eklenmelidir. Ayrica daha uzun takiplerin yapildigi calismalara ihtiyac vardir.
Genes for the alpha and gamma subunits of mouse nerve growth factor are contiguous.

Here we describe the structure and linkage of genes encoding the alpha and gamma subunits of mouse nerve growth factor (NGF). These genes are members of the highly homologous glandular kallikrein multigene family. Together with the beta subunit, the alpha and gamma proteins constitute the high mol. wt. (7S) form of NGF isolated from mouse submandibular gland. The gamma subunit is an active serine protease and is thought to cleave pro‐beta‐NGF to generate the mature growth factor. The alpha subunit has no detectable proteolytic activity, but is essential for the stable formation of 7S NGF. Lack of enzyme activity of the alpha subunit can be attributed, at least in part, to the deletion of 15 nucleotides in a highly conserved coding region which is normally involved in the activation of serine proteases from their inactive zymogen form.
DLSLA 3-D SAR Imaging Based on Reweighted Gridless Sparse Recovery Method

Downward-looking sparse-linear-array 3-D synthetic aperture radar (DLSLA 3-D SAR) cross-track reconstruction usually suffers from incomplete observation and limited resolution. The incomplete observation is caused by the sparse and nonuniform distribution of the equivalent antenna phase centers (APCs) due to the array elements' installation location restriction, loss, or deviation. Sparse recovery methods provide a solution with improved resolution from the incomplete observation for the 3-D imaging scene that behaves with spatial sparsity. However, conventional grid-based sparse recovery (GB-SR) methods are under the assumption that the scatterers are located on the discretized grids; otherwise, the off-grid effect or basis mismatch problem will occur. In this letter, we propose a reweighted scheme-based gridless sparse recovery (GL-SR) method, i.e., reweighted gridless sparse iterative covariance-based estimation (RGLS), for DLSLA 3-D SAR cross-track imaging. The proposed method possesses the merits of gridless SPICE (GLS), i.e., free of off-grid effect and user parameters, and has a statistically more appealing property than GLS by adopting the reweighted scheme. As seen from the experiments that compare the performance of GB-SR and GL-SR methods for DLSLA 3-D SAR cross-track reconstruction, the proposed method performs outstandingly under the circumstance of sparse and nonuniform APCs' distribution.
Organizational Structure: Influencing Factors and Impact on a Firm

The influence of certain factors on organizational structure has been in researchers’ focus for years, together with their impact on the overall organizational efficiency. Many of these factors are from the environment where traditional view commonly divided into internal and external factors. This paper presents the findings of a study to evaluate the influencing factors and impact on organizational structure of a sample of firms located in Hanoi, Vietnam. Structured questionnaires were administered with respect to these factors. The variables studied were identified from among the factors considered in contingency theory and by incorporating elements of the strategic choice approach. After grouping the variables into two factors (related to external and internal respectively), the results revealed three groups of firms according to how they regarded the impact of these factors on organizational structures. In those groups that consider the variables of internal factors to be modifiers of structure the organizational structures are of the “complex classical” type, whereas simple forms predominate in the group that believes these variables do not modify their structure.
The significance of vascular invasion and lymphocytic infiltration in invasive cervical cancer

Surgical specimens from 100 patients with stage I B cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy were reviewed with respect to vascular invasion and lymphoplasmacytic infiltration. Lymph nodes from these patients were classified morphologically according to the criteria proposed by Cottier. Vascular invasion was associated with a significant increase in nodal metastases and tumor recurrence particularly to extrapelvic sites. A marked lymphoplasmacytic infiltrate around tumor cells was associated with decreased nodal metastases and tumor recurrence. There was no significant relationship between the degree of lymphoplasmacytic infiltration of the primary tumor and regional lymph node morphology.
Phosphorylation of Threonine 558 in the Carboxyl-terminal Actin-binding Domain of Moesin by Thrombin Activation of Human Platelets (*)

The phosphorylation and localization of the membrane-linking protein moesin was analyzed during early activation of platelets with thrombin. Activated platelets elaborate filopodia and spread to assume flat pancake-like shapes, and moesin is localized in filopodia and cell body. In resting platelets, approximately 25% of moesin molecules are phosphorylated as shown by metabolic labeling with P and by isoelectric focusing. Within seconds after exposure to thrombin, phosphorylation increases, reaching a maximum of 35% labeled molecules by 1 min, followed by a decrease to a new basal level within 5 min. This modification affects a single residue, Thr, which is located within or close to a binding site for F-actin. Rapid shifts (0-100%) in the number of phosphorylated molecules are observed in the presence of inhibitors of serine/threonine kinases and phosphatases. Inhibitors affecting tyrosine phosphorylation also modulate phosphorylation at this site suggesting that the enzymes involved in the modification of Thr are regulated by tyrosine phosphorylation. Platelets respond to both extremes of modification by forming extremely long filopodia and the absence of spreading on glass. Completely phosphorylated moesin is concentrated together with F-actin in the center of the cell. The rapid modification of moesin at or near its actin-binding domain suggests a model for regulated membrane-cytoskeleton interaction during cell activation.