Miracle-dz/UniFAR-FTUs huggingface dataset:
PCCTS reference manual: version 1.00

This document describes the structure and use of the Purdue Compiler-Construction Tool Set (PCCTS), a set of public domain software tools designed to facilitate the implementation of compilers and other translation systems. Distribution of PCCTS is managed by an email server that reads the Sub J e c t : line of each email sent to pccts@ecn.purdue, edu. A missing or undecipherable Sub j e c t : line will cause the system to reply with email explaining how to use the server. Full C source code for PCCTS, various examples, and on-line documentation are available. PCCTS was developed within the School of Electrical Engineering at Purdue University, supported in part by NSF award number 8624385A3-CDR. As a public domain software release, Purdue University and the authors provide the system strictly on an "as-is" basis, without warranty or liability. Despite this, bug reports and fixes are welcome.
Near-native structure refinement using in vacuo energy minimization

One of the greatest shortcomings of macromolecular energy minimization and molecular dynamics techniques is that they generally do not preserve the native structure of proteins as observed by x-ray crystallography. This deformation of the native structure means that these methods are not generally used to refine structures produced by homology-modeling techniques. Here, we use a database of 75 proteins to test the ability of a variety of popular molecular mechanics force fields to maintain the native structure. Minimization from the native structure is a weak test of potential energy functions: It is complemented by a much stronger test in which the same methods are compared for their ability to attract a near-native decoy protein structure toward the native structure. We use a powerfully convergent energy-minimization method and show that, of the traditional molecular mechanics potentials tested, only one showed a modest net improvement over a large data set of structurally diverse proteins. A smooth, differentiable knowledge-based pairwise atomic potential performs better on this test than traditional potential functions. This work is expected to have important implications for protein structure refinement, homology modeling, and structure prediction.
Il self-assessment come strumento utile allo sviluppo del talento

This research wants to demonstrate that self-assessment (SSA) needs to beimplemented. Here, the term talent is understood as “personal training potentialfor development” (Tessaro 2011, pp. 355). It is linked to SSA, seen as“the qualitative assessment of learning processes and its final products”(Panadero, 2011, pp. 78) that a students acts. In order to demonstrate thatself-assessment practices play a key role in student development and learning(Andrade & Valtcheva, 2009), 109 Italian university students took part,voluntarily, at the research. The first Research Question focuses on the benefitsthe SSA can bring. The second wants to reflect on the role of studentsand teachers within SSA practices. Despite the limitation of the research,the final diagram and the reported reflections can be useful to students andto university professors, to pedagogists and to all those interested in thetopic, as a possible guideline to consider. They had been used as startingpoint for other researches, still ongoing.
Variable structure control of robots with nonlinear friction and backlash at the joints

This paper investigates the control of robots with nonlinear friction and dynamic backlash in the joints. The study is based on the describing function (DF) of nonlinear systems. The controllers studied are the first order model and the second order model variable structure controllers (FOM-VSC and SOM-VSC). The authors start by studying nonlinear plants consisting of a mass subjected to Coulomb plus viscous friction or two masses subjected to dynamic backlash. The worst case for the limit cycle generation is found to be the closed-loop system having two masses with backlash. On the other hand, the closed-loop system of a mass with nonlinear friction is found to be amenable to control without limit cycles. By decoupling the joints of the robot the authors find similar results within a good accuracy range.
Electronic structures of transition-metal mono-oxides in the self-interaction-corrected local-spin-density approximation.

The electronic structures of transition-metal mono-oxides are calculated using the self-interaction-corrected (SIC) local-spin-density approximation (LSDA). The LSDA-SIC has many solutions and various possible solutions are examined. It is shown that the total energies of these solutions are strongly affected by the choice of exchange-correlation energy functionals. Alternatively, if the solutions are chosen so that all orbitals are localized as Wannier functions, the energy gaps are overestimated by 1.5--3 eV. However, in these solutions, the relative positions of occupied transition-metal d bands and oxygen p bands are consistent with the analysis of photoemission spectroscopy by the cluster configuration interaction theory.
Design and Fabrication of Novel Symmetric Low-Loss 1 × 24 Optical Power Splitter

In this paper, a three-branch structure with different output widths, broadening, and transition waveguide are discussed in detail. Based on the three-branch structure, a compact, low-loss, and good uniformity 1 × 24 optical power splitter is designed and fabricated using silica-based PLC technology on quartz substrate. The measurement results show that the insertion loss, the uniformity, wavelength-dependence loss of the splitter are less than 14.8, 0.92, and 0.93 dB, respectively, in the wavelength range from 1.25 to 1.65 μm. The polarization dependence loss is less than 0.16 dB in the wavelength of 1.27, 1.31, 1.49, 1.55, and 1.625 μm.
Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer.

PURPOSE To achieve locoregional control of head and neck cancer, survival, and organ preservation using intensive concomitant chemoradiotherapy. PATIENTS AND METHODS This study was a phase II trial of chemoradiotherapy with cisplatin 100 mg/m(2) every 28 days, infusional fluorouracil 800 mg/m(2)/d for 5 days, hydroxyurea 1 g orally every 12 hours for 11 doses, and radiotherapy twice daily at 1.5 Gy/fraction on days 1 through 5 (total dose, 15 Gy). Five days of treatment were followed by 9 days of rest, during which time patients received granulocyte colony-stimulating factor. Five cycles (three with cisplatin) were administered over 10 weeks (total radiotherapy dose, </= 75 Gy). Adjuvant chemoprevention with retinoic acid and interferon alfa-2A was offered. RESULTS Seventy-six patients were treated (stage IV, 93%; N2, 54%; N3, 21%). At a median follow-up of 38 months, the 3-year progression-free survival is 72%, locoregional control 92%, systemic control 83%, and overall survival 55%. Toxicities included mucositis (grade 3, 45%; grade 4, 12%), neutropenia (grade 4, 39%), and thrombocytopenia (grade 4, 53%). Surgery at the primary site was performed in 13 patients, and 39 had neck dissection. A majority of patients declined adjuvant chemoprevention. Pharmacokinetic parameters were not prognostic of tumor control. Quality of life declined during treatment but returned from good to excellent by 12 months after treatment. CONCLUSION Intensive concomitant chemoradiotherapy leads to high locoregional control and survival rates with organ preservation and a reversal of the historical pattern of failure (distant > locoregional). Surgery after concomitant chemoradiotherapy is feasible. Compliance with adjuvant chemoprevention is poor. Identification of less toxic regimens and improved distant disease control emerge as important future research goals.
Evaluation of some properties of four silicon based soft denture reliner materials

Background: lining materials have been widely used for prosthodontics rehabilitation. One unresolved problem is the easy adherence of Candida to these materials because roughness of porous surface, inadequate adhesion of silicon to acrylic denture base is the most problem of the silicone soft liner material. Although silicone soft liner materials have more stability when compared with acrylic based type of soft liner material but they still show several disadvantages like the material have susceptibility to water absorbed of solvents and particular water and loss of soluble components and this lead to effect the strength of bond and change visicoelasticity of material. The purpose of this study was to compare among four silicone based soft liner materials (permaflex and Molloplast, Ufi Gel SC and permafix) in invitro investigations properties shear bond, water sorption and solubility and surface
Fano Resonance Filtering Characteristic of High-Resistivity Silicon Photonic Crystal Slab in Terahertz Region

We investigate experimentally and numerically the Fano resonances of terahertz waves through a high resistivity silicon photonic crystal slab with a hexagonal array of circular air holes. Finite-difference time-domain simulation and terahertz time-domain spectroscopy transmission measurement show good agreement with the data, in support of the Fano resonance mechanism. The frequency dependent transmission spectra show there is a Fano resonance bandpass filtering characteristic at the center frequency of 2.10 THz with a Q factor of 191, which is consistent with that of Fano resonance theory calculation.
Muscle Strength and Functional Ability in Recreational Female Golfers and Less Active Non-Golfers over the Age of 80 Years

Muscle strength and functional ability decline with age. Physical activity can slow the decline but whether recreational golf is associated with slower decline is unknown. This cross-sectional, observational study aimed to examine the feasibility of testing muscle strength and functional ability in older female golfers and non-golfers in community settings. Thirty-one females over aged 80, living independently (golfers n = 21, mean age 83, standard deviation (±) 2.1 years); non-golfers, n = 10 (80.8 ± 1.03 years) were studied. Maximal isometric contractions of handgrip and quadriceps were tested on the dominant side. Functional ability was assessed using the Timed Up and Go (TUG) and health-related quality of life using the Short Form-36 questionnaire. Grip strength, normalised to body mass, was greater in golfers (0.33 ± 0.06 kgF/kg) than non-golfers (0.29 ± 0.06), however, the difference was not statistically significant (p = 0.051). Quadriceps strength did not differ (golfers 2.78 ± 0.74 N/kg; non-golfers 2.69 ± 0.83; p = 0.774). TUG times were significantly faster (p = 0.027) in golfers (10.4 ± 1.9 s) than non-golfers (12.6 ± 3.21 s; within sarcopenic category). Quality of life was significantly higher in golfers for the physical categories (Physical Function p < 0.001; Physical p = 0.033; Bodily pain p = 0.028; Vitality p = 0.047) but psychosocial categories did not differ. These findings indicated that the assessment techniques were feasible in both groups and sensitive enough to detect some differences between groups. The indication that golf was associated with better physical function than non-golfers in females over 80 needs to be examined by prospective randomised controlled trials to determine whether golf can help to achieve the recommended guidelines for strengthening exercise to protect against sarcopenia.
Measuring Nursing Informatics Competencies of Practicing Nurses in Korea: Nursing Informatics Competencies Questionnaire

Informatics competencies are a necessity for contemporary nurses. However, few researchers have investigated informatics competencies for practicing nurses. A full set of Informatics competencies, an instrument to measure these competencies, and potential influencing factors have yet to be identified for practicing nurses. The Nursing Informatics Competencies Questionnaire was designed, tested for psychometrics, and used to measure beginning and experienced levels of practice. A pilot study using 54 nurses ensured item comprehension and clarity. Internal consistency and face and content validity were established. A cross-sectional survey was then conducted on 230 nurses in Seoul, Korea, to determine construct validity, describe a complete set of informatics competencies, and explore possible influencing factors on existing informatics competencies. Principal componentsanalysis, descriptive statistics, and multiple regression were used for data analysis. Principal components analysis gives support for the Nursing Informatics Competencies Questionnaire construct validity. Survey results indicate that involvement in a managerial position and self-directed informatics-related education may be more influential for improving informatics competencies, whereas general clinical experience and workplace settings are not. This study provides a foundation for understanding how informatics competencies might be integrated throughout nurses’ work lives and how to develop appropriate strategies to support nurses in their informatics practice in clinical settings.
The effect and safety of highly standardized Ginger (Zingiber officinale) and Echinacea (Echinacea angustifolia) extract supplementation on inflammation and chronic pain in NSAIDs poor responders. A pilot study in subjects with knee arthrosis

Abstract The study aimed to evaluate the effect of Zingiber officinale and Echinacea angustifolia extract supplementation (25 mg of ginger and 5 mg of Echinacea) for 30 days on inflammation and chronic pain in knee osteoarthritis (OA). Consecutive nonsteroidal anti-inflammatory-drugs (NSAIDs) poor responders with chronic inflammation and pain due to knee arthrosis were assessed (15 subjects, age: 67.2 ± 7.9, body mass index: 30.6 ± 7.1, men/women:2/13). The primary endpoint was to determine pain improvement from baseline to Day 30 by Tegner Lysholm Knee Scoring. The secondary endpoints were the assessment of Visual Analog Scale for Pain, health-related quality of life, by the ShortForm36 (SF-36), anthropometric parameters, hydration. After supplementation, a significant improvement of 12.27 points was observed for Lysholm scale score (p < 0.05), SF-36 (p < 0.05), and a decrease in −0.52 cm in knee circumference (left) (p < 0.01). This pilot study provides feasibility and safety data for the use of highly standardised ginger and Echinacea extract supplementation in people with knee OA. Graphical Abstract
Degenerations of the Dog Retina *

THIS syndrome of central progressive atrophy of the retina in which central vision is lost in middle age while peripheral vision is retained until old age is unlike the generalized degenerations of the dog retina described in the preceding papers of this series, in two principal particulars: the distribution of the degeneration and the occurrence in the fundus of pigment foci which may be seen with the ophthalmoscope. The syndrome was first recognized clinically when small foci of irregular pigmentation were observed in the tapetal fundus of dogs with a history of very gradual bilateral impairment of day and night vision coming on in middle or late life. The impairment of vision was due to the development of a central scotoma; the day and night vision of the peripheral fundus remained unimpaired. The electroretinogram was normal in the early stages of the disease, but in the later stages first the negative wave could not be detected and finally the b-wave was lost. In histological preparations the central retina was found to be degenerate, the pigment epithelium dystrophic, and the choroid somewhat thinned.
Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock1

We report here that miR-155 and miR-125b play a role in innate immune response. LPS stimulation of mouse Raw 264.7 macrophages resulted in the up-regulation of miR-155 and down-regulation of miR-125b levels. The same changes also occurred when C57BL/6 mice were i.p. injected with LPS. Furthermore, the levels of miR-155 and miR-125b in Raw 264.7 cells displayed oscillatory changes in response to TNF-α. These changes were impaired by pretreating the cells with the proteasome inhibitor MG-132, suggesting that these two microRNAs (miRNAs) may be at least transiently under the direct control of NF-κB transcriptional activity. We show that miR-155 most probably directly targets transcript coding for several proteins involved in LPS signaling such as the Fas-associated death domain protein (FADD), IκB kinase ε (IKKε), and the receptor (TNFR superfamily)-interacting serine-threonine kinase 1 (Ripk1) while enhancing TNF-α translation. In contrast, miR-125b targets the 3′-untranslated region of TNF-α transcripts; therefore, its down-regulation in response to LPS may be required for proper TNF-α production. Finally, Eμ-miR-155 transgenic mice produced higher levels of TNF-α when exposed to LPS and were hypersensitive to LPS/d-galactosamine-induced septic shock. Altogether, our data suggest that the LPS/TNF-α-dependent regulation of miR-155 and miR-125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design.
Indicadores diferenciales de personalidad frente al riesgo de suicidio en adolescentes

La reaccion de los individuos ante las adversidades varia en funcion de los recursos personales que poseen. El proposito de este estudio fue identificar las diferencias en las caracteristicas de personalidad de adolescentes resilientes y no resilientes ante el riesgo de suicidio. De una muestra de 1,084 jovenes de bachillerato, se seleccionaron a 106 adolescentes expuestos a niveles similares de estres, pero con resultados distintos en su adaptacion al riesgo suicida. Se emplearon el Cuestionario de Sucesos de Vida para Adolescentes (Lucio & Duran, 2003); el Inventario de Riesgo Suicida (Hernandez & Lucio, 2003) y el Inventario Multifasico de la Personalidad Minnesota- Adolescentes (Lucio, Ampudia & Duran, 2004). Los resultados indican que los adolescentes no resilientes presentan en mayor medida sintomas fisicos, de depresion y ansiedad que los adolescentes resilientes, al mismo tiempo que se obtuvieron diferencias significativas en los rasgos de personalidad entre los hombres y mujeres resilientes y no resilientes.
Separate anti‐inflammatory effects of indomethacin, flurbiprofen and benoxaprofen

An important query about non-steroidal anti-inflammatory drugs is whether they have either a common single mode of action or different multiple interactions with various aspects of inflammatory responses. An inhibitory action on prostaglandin biosynthesis has been advanced as a mechanism for the first possibility (Vane, 1973). More recently evidence has accumulated that the drugs possess anti-inflammatory effects which appear to be independent of prostaglandin systems (Bonta, Bult & others, 1977; Crook, Collins &others, 1976). One of the most relevant is an interference with the emigration of leucocytes into inflammatory sites (Walker, Smith & Ford-Hutchinson, 1976a). In the present work the effects of three acidic non-steroidal drugs, indomethacin, flurbiprofen and benoxaprofen, on the production of prostaglandins and the migration of leucocytes into an inflammatory exudate in vivo, have been studied. All three drugs possess a similar spectrum of experimental anti-inflammatory activity (Glenn, Rohloff & others, 1973 ; Adams, McCullough & Nicholson, 1975; Cashin, Dawson & Kitchen, 1977) but differ in that the first two are potent inhibitors of prostaglandin synthetase activity in vitro (Crook & Collins, 1975) whereas benoxaprofen is only a weak inhibitor of the enzyme system (Cashin & others, 1977). Indomethacin was obtained from Merck Sharp and Dohme. Benoxaprofen (2-[4-chlorophenyl]-cc-methyl-5benzoxazone acetic acid) was obtained from Dr W. Dawson, Lilly Research Centre, Ltd, Windlesham, Surrey, England, and flurbiprofen (2-[fluoro-4-biphenylyl] propionic acid) was obtained from Dr S. Adams, Boots Drug Co. Ltd, Nottingham, England. The 9 h sponge implantation technique, the estimation of leucocyte migration and prostaglandin-like activity in the sponges were as described previously (Walker & others, 1976a). Drugs were administered orally as a suspension in Tween 80 to groups, each of 5 rats, 1 h before sponge implantation. The effects of the three drugs on prostaglandin accumulation and leucocyte migration into the 9 h sponge exudates are shown in Table 1 . Indometha& and flurbiprofen, which are potent inhibitors of prosta. glandin synthetase in vitro, strongly inhibited the accumulation of prostaglandin activity in vivo in the sponges. This inhibition occurred at lower dosages than those required to inhibit white cell migration in the system and well below those required to inhibit other experimental models of inflammation (Glenn & others, 1973; Adams & others, 1975). Benoxaprofen only showed inhibition of prostaglandin production in vivo at doses equivalent to those required to inhibit white cell migration in the model and similar to those needed to affect other experimental models (Cashin & others, 1977). These findings demonstrate a lack of correlation
The characteristics of anxiety and depression symptom severity in older adults living in public housing

ABSTRACT Background: Anxiety and depression are common in older adult public housing residents and frequently co-occur. To understand anxiety and depression more fully in this socioeconomically disadvantaged population, this study relies on the Social Antecedent Model of Psychopathology to characterize anxiety and depression symptoms concurrently. Methods: 190 public housing residents aged 60 years and older in Rochester, New York, participated in a research interview during which they reported on variables across the six stages of the Social Antecedent Model. GAD-7 and PHQ-9 assessed anxiety and depression symptoms, respectively. Results: In these older adult residents, anxiety and depression symptom severity scores were correlated (r = 0.61; p < 0.001). Correlates of anxiety and depression symptom severity were similar for both outcomes and spanned the six stages of the Social Antecedent Model. Multivariate linear regression models identified age, medical comorbidity, mobility, social support, maladaptive coping, and recent life events severity as statistically significant correlates. The regression models accounted for 43% of anxiety and 48% of depression symptom variability. Conclusions: In public housing residents, late-life anxiety and depression symptoms were moderately correlated. Anxiety symptom severity correlates were largely consistent with those found for depression symptom severity. The broad distribution of correlates across demographic, social, medical, and behavioral domains suggests that the context of late-life anxiety and depression symptomatology in public housing is complex and that multidisciplinary collaborative care approaches may be warranted in future interventions.
A study on an efficient spatialisation technique for near-field sound in video games

This article presents a simple and efficient method for spatialising sound in virtual environments by adding low pass filters (LPF) to the already widespread panning and attenuation techniques. Through two different experiments, variations in subject performance when locating sounds in a virtual environment between regular 3D audio from popular game engines (Unreal Engine and Unity) and our proposed sound system were evaluated. The first experiment consists of an audio-only test via an online survey, whereas the second experiment employs a minimalistic 3D video game which allows for user interaction guided by sound. Results of both experiments suggest better performance and accuracy when using LPFs, the second one finding a significant difference when comparing both techniques. We conclude that the LPF technique, as a mean for spatialisation of sounds coming from behind the subject, could be applied to complement current audio systems due to their performance-oriented nature and their good results with real users.