Miracle-dz/UniFAR-FTUs huggingface dataset:
Screening the key genes of prognostic value in the microenvironment for head and neck squamous cell carcinoma

Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth common malignancy worldwide. The tumor microenvironment is highly related to tumor initiation, progression, and prognosis. This study aims to screen the tumor microenvironment related key genes of prognostic value for HNSCC. The gene expression and clinical data for HNSCC were downloaded from the cancer genome atlas (TCGA). The immune/stromal/ESTIMATE scores were downloaded from the website of the MD Anderson Cancer Center. Correlation of patient gender and tumor grade with immune/stromal/ESTIMATE score was tested. Patients were divided into low and high immune/stromal/ESTIMATE score subgroups. Survival analysis was performed to evaluate the prognostic value of the immune/stromal/ESTIMATE score. Tumor microenvironment related differentially expressed genes were determined and applied for functional enrichment analysis and protein-protein interaction network was predicted. The prediction value of the common differentially expressed genes on patient survival was tested. Four hundred eighty samples with complete clinical, expression data, and immune/stromal/ESTIMATE scores were enrolled for analysis. Immune/stromal/ESTIMATE score was higher in female patients than males. A total of 44 common differentially expressed genes were screened in high and low immune/stromal/ESTIMATE score subgroups. Of the 44 genes, 7 genes (ADGRG7, CSN3, CST8, KRT81, MUC7, MYH6, and SEZ6) were found to be closely related to patient survival. Enrichment analysis showed that the differentially expressed genes mainly enriched in the protein-coupled receptor signaling pathway, extracellular region, G-protein coupled receptor activity, salivary secretion, and regulation of lipolysis in adipocytes. Protein-protein interaction analysis revealed that POSTN and OGN were crucial microenvironments related genes. Tumor microenvironment related genes ADGRG7, CSN3, CST8, KRT81, MUC7, MYH6, and SEZ6 are valuable predictors for HNSCC patient survival. POSTN and OGN are crucial in modulating the microenvironment and tumor biology for HNSCC.
Diabetes mellitus risk after hysterectomy

Abstract We explored whether hysterectomy with or without bilateral oophorectomy was associated with the increasing incidence of diabetes mellitus (DM) in an East Asian population. This was a retrospective population-based cohort study that analyzed DM risk in Taiwanese women, using a health insurance research database of 1998 to 2013 containing nearly 1 million people. We identified 7088 women aged 30 to 49 years who had undergone hysterectomy with or without oophorectomy. The comparison group included 27,845 women without a hysterectomy who were randomly selected from the population and matched to women in the hysterectomy group by age (exact year) and year of the surgery. DM comorbidities were identified. The incidence and hazard ratios for DM were calculated with Cox proportional hazard regression models. The median ages of patients in the hysterectomy and comparison groups were both approximately 44 years. After a median 7.1 years of follow-up, the incidence of DM was 40% higher in the hysterectomized women as compared with the comparisons (9.12 vs 6.78/1000 person-years, P < .001), with an adjusted hazard ratio (aHR) of 1.37 (95% confidence interval [CI] = 1.23 –1.52). However, the DM risk was not increased in the women with hysterectomy plus oophorectomy (aHR=1.28, 95% CI = 0.93–1.76). Furthermore, among women aged 30 to 39 years, 40 to 49 years, the risk in hysterectomized women was higher than the comparisons (aHR = 1.75, 95% CI = 1.27–2.41; aHR = 1.33, 95% CI = 1.19–1.49, respectively). Our study provides essential and novel evidence for the association between hysterectomy and DM risk in women aged 30 to 49 years, which is relevant to these women and their physicians. Physicians should be aware of the increased DM risk associated with hysterectomy and take this into consideration when evaluating a patient for a hysterectomy. The current results might help gynecologists prevent DM and encourage diagnostic and preventive interventions in appropriate patients.
How demographic and clinical characteristics contribute to the recovery of post-stroke dysphagia?

Abstract According to the analysis to find out how demographic and clinical characteristics influent the dysphagia outcome after stroke, furthermore, giving some insights to clinical treatment. One hundred eighty post-stroke dysphagia (PSD) patients were enrolled in this retrospective study at the stroke rehabilitation department. The outcome measurements are beside water swallow test at discharge and length of stay at hospital. Twenty-five demographic and clinical variables were collected for this study. Logistic regression and multilinear regression were utilized to estimate models to identify the risk and protect predictors of PSD outcome. Mouth-opening degree, drooling severity scale (DSS) level, mini-mental state exam (MMSE) level, Barthel index and Berg balance scale were significant different between recovered and unrecovered group. Type of stroke, MMSE degree, DSS and hemoglobin level shown significant predictive value for PSD outcome in logistic regression. In addition, obstructive sleep apnea (OSA) and DSS degree were important risk factors for PSD outcome. Gender, body mass index, drinking, hypertension, recurrent stroke, water swallow test level on admission, Berg balance scale, DSS and days between onset to admission shown significant predictive value for length of stay of PSD patients. PSD outcome was influenced by type of stroke, MMSE degree, DSS and hemoglobin level significantly and obstructive sleep apnea act as an important risk role for PSD recovery.
Clinical manifestation of multiple wasp stings with details of whole transcriptome analysis

Supplemental Digital Content is available in the text Abstract Introduction: Multiple wasp stings is an emergency result from systemic reactions to the toxin with a wide range of manifestations, and we presented 2 patients with distinct clinical and transcriptomic findings. Patient concerns: Two patients without systemic disease presented with nearly 90 painful papules after attacked by a swarm of wasps (Vespa basalis). Diagnosis: Patient 1 was a 44-year-old healthy male whose clinical manifestations mainly comprised hemolysis, hepatic injury, rhabdomyolysis, and acute kidney injury. Patient 2 was a 49-year-old healthy female who presented with severe acute respiratory distress syndrome (ARDS) in addition to certain clinical manifestations that were also found in patient 1. We used ribo- nucleic acid sequencing (RNA-Seq) to characterize the inflammatory responses of 2 patients with distinct clinical manifestations after multiple wasp stings. Interventions: Both 2 patients received 5 sessions of plasmapheresis, and patient-1 further received mechanical ventilation for 8 days as well as 8 sessions of hemodialysis until day 17. Outcomes: Both patients recovered uneventfully after the aforementioned management. We used RNA-Seq to demonstrate a largely regulated neutrophil-predominated immune response in patient 1. In patient 2, we found a profound neutrophilc response on week 1 and a robust neutrophilic as well as pro-inflammatory responses on week 2. Furthermore, we found increased expression of signals that were associated with renal system process on week 2. Conclusion: In conclusion, we report 2 patients who manifested with shared and distinct presentations after an attack by the same swarm of wasps. Both patients had hemolysis, rhabdomyolysis, hepatic injury and acute kidney injury, and 1 patient had ARDS. The whole transcriptomic analyses were consistent with the distinct clinical manifestation, and these results suggest the potential of RNA-Sequencing to disentangle complex inflammatory responses in patients with multiple wasp stings. Plasmapheresis and corticosteroid were administered to both patients and case 2 also underwent 8 sessions of hemodialysis.
A meta-analysis

Objective: To evaluate the clinical and radiographic outcomes of total knee arthroplasties (TKA) between using medial-pivot (MP) and posterior-stabilized (PS) prosthesis. Does MP prosthesis and PS prosthesis influence the clinical results of a TKA? Methods:An electronic literature search of PubMedMedline and the Cochrane Library was performed from inception to October 1, 2019. A meta-analysis to compare postoperative outcomes of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, Knee Society Score (KSS), range of motion (ROM), complications, and radiographic results between MP and PS prosthesis were conducted. Results:Seven eligible studies involving 934 adult patients (MP group, n=461; PS group, n=473) were identified for analysis. This study showed no significant difference between the 2 groups in the WOMAC scores, KSS, ROM, and complications (P> .05). The differences of the femorotibial angle, position of implant, and patellar tilt were also not significant between the 2 groups (P> .05). Conclusion:The present meta-analysis has shown that patients with the MP prosthesis have similar clinical results as patients with PS prosthesis. Furthermore, the radiographic results, especially patella tilt angle, were also similar between the 2 groups. Therefore, surgeons should be aware that the types of prostheses are not a decisive factor to ensure successful operation. Abbreviations: CI = confidence interval, FJS = forgotten joint score, KFS = Knee Society Function Score, KKS = Knee Society Knee Score, KSS = Knee Society Score, MD = mean difference, MP = medial pivot, PS = posterior-stabilized, ROM = range of motion, RR = risk ratio, TKA = total knee arthroplasties, UKA = unicompartmental knee arthroplasty, WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index.
A protocol for systematic review and meta-analysis

)) OR (CVA[Title/Abstract])) OR (CVAs [Title/Abstract])) OR (Cerebrovascular Apoplexy[Title/Abstract])) OR (Apoplexy, Cerebrovascular[Title/ Abstract])) OR (Vascular Accident, Brain[Title/Abstract])) OR (Brain Vascular Accident [Title/Abstract])) OR (Brain Vascular Accidents[Title/Abstract])))) OR (Vascular Accident, Brain[Title/Abstract])) OR (Brain Vascular Accident [Title/Abstract])) OR (Brain Vascular Accidents[Title/Abstract])) OR (Vascular Accidents, Brain[Title/Abstract])) OR (Cerebrovascular Stroke [Title/Abstract])) OR (Cerebrovascular Strokes [Title/Abstract])) OR (Stroke, Cerebrovascular [Title/Abstract])) OR (Strokes, Cerebrovascular [Title/Abstract])) OR (Apoplexy [Title/Abstract])) OR (Cerebral Stroke [Title/ Abstract])) OR (Cerebral Strokes [Title/Abstract])) OR (Stroke, Cerebral [Title/Abstract])) OR (Strokes, Cerebral [Title/Abstract])) OR (Stroke, Acute)) OR (Cerebral Strokes [Title/Abstract])) OR (Stroke, Cerebral [Title/Abstract])) OR (Strokes, Cerebral [Title/Abstract])) OR (Stroke, Acute [Title/Abstract])) OR (Acute Stroke [Title/Abstract])) OR (Acute Strokes [Title/Abstract])) OR (Strokes, Acute [Title/Abstract])) OR (Cerebrovascular Accident, Acute [Title/Abstract])) OR (Acute Cerebrovascular Accident[Title/Abstract])) OR (Acute Cerebrovascular Accidents [Title/Abstract])) OR (Cerebrovascular Accidents, Acute [Title/Abstract]))) #2 ((((Dysphagia [MeSH Terms]) OR (Deglutition Disorder [Title/Abstract])) OR (Swallowing Disorder [Title/Abstract])) OR (Oropharyngeal Dysphagia [Title/ Abstract])) OR (swallowing difficulty [Title/Abstract]))) OR (swallowing difficulty [Title/Abstract])
Efficacy and safety of TCM therapies combined with hyperthermic intraperitoneal chemotherapy for peritoneal metastasis of gastric cancer

Abstract Background: Gastric cancer (GC) has high incidence and mortality worldwide, and peritoneal metastasis is a primary cause of mortality in patients. Hyperthermic intraperitoneal chemotherapy (HIPEC) is a feasible and effective treatment. Traditional Chinese Medicine (TCM) therapies have been combined with HIPEC for certain therapeutic advantages, but there is a lacking of evidence of evidence-based medicine. Therefore, we provide a protocol to evaluate the efficacy and safety of TCM therapies combined with HIPEC in the treatment for peritoneal metastasis of GC. Methods and analysis: From inception until December 2020, a systematic and comprehensive literature search will be conducted in both 3 English databases and 4 Chinese databases. Randomized controlled trials (RCTs) will be included related to TCM therapies combined with HIPEC in the treatment for peritoneal metastasis of GC. Two researchers independently conducted data extraction and literature quality evaluation. The methodological qualities, including the risk of bias, will be evaluated using the Cochrane risk of bias assessment tool, while confidence in the cumulative evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results: This study assessed the efficacy and safety of TCM therapies combined with HIPEC in the treatment of peritoneal metastasis of GC by effective rate, Karnofsky Performance Status (KPS), Carcinoemybryonic Angtigen remission rate, and incidence of adverse reactions etc. Conclusions: This study will provide reliable evidence-based evidence for the clinical application of TCM therapies combined with HIPEC in the treatment for peritoneal metastasis of GC. Ethics and dissemination: Ethical approval is not required, as this study is based on the review of published research. This review will be published in a peer-reviewed journal and disseminated both electronically and in print. Registration number: INPLASY2020120048.
Sex-related associations among anemia, body mass index, and kidney function in Koreans

Abstract The association between anemia and body mass index (BMI) in Koreans, considering kidney function, has not been clarified. Thus, we aimed to examine the association between anemia and BMI among Korean adults aged ≥19 years. This retrospective cross-sectional study evaluated male and female Korean adults aged ≥19 years who participated in the 5th, 6th, and 7th Korean National Health and Nutrition Examination Surveys (KNHANES) conducted between 2010 and 2017 were used. The participants were classified as underweight, normal weight, and overweight according to their BMI. Anemia was defined as hemoglobin levels of <13 g/dL for men and <12 g/dL for women according to the World Health Organization standards. Kidney function was evaluated according to the estimated glomerular filtration rate (eGFR), with abnormal kidney function in men defined as eGFR <60 mL/min/1.73 m2. Clinicodemographic variables were analyzed using logistic regression adjusted for weight. After propensity score matching (PSM), 6596 study participants were divided into 2 groups of 3298 participants each. Additionally, subgroup analysis by sex and kidney function was performed. On PSM, similar distribution patterns were obtained between the anemia and non-anemia groups; significant differences in BMI; kidney function; level of hemoglobin, hematocrit, and serum creatinine; iron intake; and eGFR were also observed between these groups. Anemia and BMI showed a significant association in both crude and adjusted logistic regression models. In model 2, which was adjusted for age, sex, education level, household income, alcohol consumption, smoking status, and exercise period, underweight men with abnormal kidney function showed a significantly higher risk of anemia than did normal weight men (odds ratio [OR]: 3.27; 95% confidence interval [CI]: 1.25–8.57; P = .016). Meanwhile, overweight men showed a significantly lower risk of anemia than did normal weight men (OR: 0.48; 95% CI: 0.33–0.70, P < .001). Anemia is associated with BMI according to sex. Compared with normal weight men, underweight men with abnormal kidney function had a significantly higher prevalence of anemia after adjusting for kidney function and sex, thus highlighting their need for careful management for anemia.
Defect characterization of cBN single crystals grown under HP/HT

The defects of cBN single crystals were characterized by their optical absorption and etch-pit density. The crystals were synthesized by using temperature gradient method under high pressure. Compounds of alkali metal and/or alkali earth metal-boron nitride and metal of Ni-Al alloy were used as solvent for the crystal growth. Recovered crystals exhibited a variety of colors and crystalline natures, which were characterized by optical absorption and Raman spectroscopy. Chemical treatment was applied to the typically grown crystals so as to evaluate their etch-pit density. Colorless crystals obtained by using Ba-BN solvent system revealed superior properties showing high optical transmittance as well as lower etch-pit density of the order of 10 4 /cm 2 .
A New Kinetic Model for Polypropylene Thermal Oxidation at Moderate Temperatures

This work deals with a mechanistic scheme for polymer oxidation, in which the unique source of radicals is the unimolecular decomposition of hydroperoxides. The corresponding kinetic scheme is resolved in the general case where no stationary state for radical concentration is postulated. The numerical results are in good agreement with experimental data such as, for instance (a) the existence of a close relationship between the duration of the “induction period” and the reciprocal of the POOH decomposition rate constant, (b) the fact that the induction time tends toward a finite value when the initial POOH concentration tends toward zero, and (c) the fact that the steady state rate is independent of the POOH decomposition rate constant and that the apparent activation energy of oxidation varies with the exposure time. The practical use of this model appears, however, almost impossible, owing to the difficulty of determining certain parameters. Fortunately, a peculiar solution of the kinetic scheme based o.
MOSDA: On-Chip Memory Optimized Sparse Deep Neural Network Accelerator With Efficient Index Matching

The irregular data access pattern caused by sparsity brings great challenges to efficient processing accelerators. Focusing on the index-matching property in DNN, this article aims to decompose sparse DNN processing into easy-to-handle processing tasks to maintain the utilization of processing elements. According to the proposed sparse processing dataflow, this article proposes an efficient general-purpose hardware accelerator called MOSDA, which can be effectively applied for operations of convolutional layers, fully-connected layers, and matrix multiplications. Compared to the state-of-art CNN accelerators, MOSDA achieves <inline-formula> <tex-math notation="LaTeX">$1.1 \times $ </tex-math></inline-formula> better throughput and <inline-formula> <tex-math notation="LaTeX">$2.1 \times $ </tex-math></inline-formula> better energy efficiency than Eyeriss v2 in sparse Alexnet in our case study.
RCTC: Rateless Cross-technology Communication

Cross-Technology Communication (CTC) is an emerging technique that enables the direct communication across incompatible wireless technologies. Without modifying any hardware, CTC establishes mutually sensible side channel by manipulating the packet transmissions and encodes information by constructing transmission patterns in terms of signal strength, packet interval, and etc. However, the transmission patterns are prone to the coexisting interference, leading to the unreliability of CTC. Most of the existing methods deal with the reliability problem by reactive retransmission of the corrupted packets, which incurs large delay. In this paper, we propose RCTC, a rateless-coding based CTC that proactively copes with the unreliability. Since the computation ability of low-power ZigBee nodes is limited, we carefully design the coding combination with proper degree distribution to balance the trade-off between reliability and decoding latency. We also propose a coding adaptation algorithm to adapt to the channel dynamics. We implement a prototype on commercial WiFi and ZigBee platforms. The experiment results show that RCTC can reduce the BER by up to 92.6%, compared to existing CTC methods.
Fabrication of titania tubules with high surface area and well-developed mesostructural walls by surfactant-mediated templating method

Titania microtubules with high specific surface areas and well-developed framework mesopores forming the tubular walls by a surfactant-mediated template in the sol−gel process were fabricated in a laurylamine hydrochloride (LAHC)/tetra-n-butyl-orthotitanate (TBOT) system. The outer diameter and the wall thickness of titania microtubules are 2−8 and 0.2−2 μm, respectively. The walls of the microtubules consisted of nanochannels with exceptionally uniform pore size. This technique is a convenient and facile procedure for fabricating hierarchical ordered hollow tubules. The possible mechanism of the formation of the microtubules in the present system was discussed in detail.
Decentralized Incentive Mechanism for Cooperative Content Dissemination in Vehicular Networks

Cooperative content dissemination allows vehicles to directly retrieve content from each other by vehicle-tovehicle (V2V) communications. It can release the downlink traffic pressure caused by repetitive of popular content downloads. A critical but open issue is how to motivate vehicles to participate in content dissemination. Most of the existing incentive mechanisms are proposed under a centralized architecture that suffers from the single point attack and trustless third-platform. In this paper, we propose a decentralized incentive mechanism for cooperative content dissemination in vehicular networks. By introducing the Directed Acyclic Graph (DAG) based blockchain technology, a decentralized architecture is proposed, which can improve incentive efficiency and reliability by removing the third-platform. Next, using the contract theory, the vehicles are divided into different types according to their route feature, and a series of contracts are designed for different types of vehicles to provide suitable incentives, as well as maximize the content generators’ profit. Simulation results demonstrate the effectiveness and efficiency of our solution.
Smart Power Unit—mW-to-nW Power Management and Control for Self-Sustainable IoT Devices

Self-sustainability and intelligence will be critical features of the next generation of Internet of Things devices. Power management circuits need to be energy-efficient in multiple power modes, from nW sleep to mW active, and to support energy harvesting (EH) from multiple environmental sources. This article presents an adaptive and firmware-configurable power supply unit that enables intelligent devices to operate in the sub μW range while achieving self-sustainability through EH. The microcontroller-based design allows efficient conversion from batteries, dc, ac environmental sources, and nA quiescent currents. Source and load power points are decoupled with multiple dc–dc converters aiming to supply loads with adaptive voltage scaling and achieving high reliability. Experimental results show the flexibility and efficiency of this approach: the proposed power supply unit achieves a quiescent current of 54 nA and a maximum peak load current of 300 mA, delivered with an end-to-end power efficiency above 85%.