Miracle-dz/UniFAR-FTUs huggingface dataset:
Promotion of N-nitrosodiethylamine-initiated hepatocellular tumors and hepatoblastomas by 2,3,7,8-tetrachlorodibenzo-p-dioxin or Aroclor 1254 in C57BL/6, DBA/2, and B6D2F1 mice.

To investigate the hypothesis that tumor promotion by chlorinated aromatic hydrocarbons involves Ah receptor occupation and subsequent induction of cytochromes P-450 1a-1, effects of Aroclor 1254 or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were examined in N-nitrosodiethylamine-initiated mice with different Ah receptor phenotype. Levels of cytochromes P-450 1a and 2b were measured by enzyme assay and Western immunoblots. Males of the C57BL/6, DBA/2, or (C57BL/6 x DBA/2)F1 (hereafter referred to as "B6D2F1") strain were initiated with a single i.p. dose of N-nitrosodiethylamine (90 mg/kg body weight), followed by either multiple doses of TCDD (0.05 micrograms/kg) weekly or Aroclor 1254 chronically in the diet (100 ppm) for 20 weeks, and then no treatment for 24 weeks. Lung tumor incidence or multiplicity was not altered by either of the promoters. Liver tumor incidence was similar among the three strains after N-nitrosodiethylamine alone (14, 21, and 21%, respectively). In DBA/2 mice, TCDD neither induced Cyp 1a nor promoted liver tumors. Aroclor caused an 8-fold induction of hepatic Cyp 2b, which was its maximum at the 12-week time point but did not promote tumors. Inductions of hepatic Cyp 1a by TCDD and 1a and 2b by Aroclor were similar in C57BL/6 and B6D2F1 mice, but tumor promotion responses were quite different. Dietary Aroclor significantly promoted liver tumors in C57BL/6 mice (59 versus 14%) but not in B6D2F1 mice (24 versus 21%). Repeated TCDD promoted only in B6D2F1 mice (52 versus 21%) and not in C57BL/6 mice (19 versus 14%). Thus, whereas these data confirm that a functional Ah receptor is required for liver tumor promotion, the degree of activation as measured by induction of Cyp 1a is not directly related to the degree of tumor-promoting capability. Other genetic factors must play a role in mediating the final tumor outcome.
An Assessment of the Fiscal Features of the PDP Laban Model of Philippine Federalism 1.0 and the Gonzales-De Vera Federal Model

The paper highlights the importance of the design of the fiscal features of the federal system of government in ensuring that potential benefits from its adoption are realized. This economic literature on fiscal federalism posits a framework that delineates the potential benefits ensuing from the adopting a federal system of government and expounds on the principles that can guide the design of the elements of the fiscal architecture to achieve the benefits. This paper also presents an approach on how to assess the design of the fiscal aspects of alternative federal models and illustrates its application in evaluating the PDP Laban Model of Philippine Federalism 1.0 and the Gonzales-De Vera model. The approach of the assessment involves benchmarking of the relevant provisions of these two models against the guiding principles emanating from the fiscal federalism. The assessment also considered current practices through a review of the constitutions of various federal countries.
Major Central Nervous System Myelin Glycoprotein of the African Lungfish (Protopterus dolloi) Cross‐Reacts with Myelin Proteolipid Protein Antibodies, Indicating a Close Phylogenetic Relationship with Amphibians

Abstract: CNS myelin was isolated from the spinal cord of the African lungfish Protopterus dolloi. Its proteins consisted of (1) two basic proteins (16,000 and 18,500 apparent Mr) that reacted with anti‐human CNS myelin basic protein antibodies and (2) a major protein (29,000 apparent Mr) that stained with concanavalin A‐horseradish peroxidase and bound to anti‐rat CNS myelin proteolipid protein (PLP) antibodies. This dominant 29,000 Mr protein showed no reaction with antibodies against the major bovine PNS myelin glycoprotein P0. Following treatment with endoglycosidase F the 29,000 Mr protein was reduced in size to a 26,000 apparent Mr component that no longer bound concanavalin A but retained the anti‐PLP reactivity. These results agree with a concanavalin A‐binding oligosaccharide linked through asparagine to a protein backbone of PLP homology. The major 29,000 Mr lungfish CNS myelin protein was therefore termed g‐PLP (glycosylated proteolipid protein). This is the first report demonstrating the occurrence of a PLP‐cross‐reactive protein in CNS myelin of a fish. It attests to the close phylogenetic relationship of lungfishes to amphibians. Amphibians were previously recognized as the oldest class bearing PLP in its CNS myelin.
Adaptable Ring for Vision-Based Measurements and Shape Analysis

A vision-based measurement approach for pill shape detection is presented along with other applications. Rapid and accurate pill identification is needed by medical and law enforcement personnel during emergencies. But real-world pill identification is challenging due to varied lighting conditions, minor manufacturing defects, and subsequent pill wear. Surmounting these challenges is possible using multiple inputs: pill color, imprint, and shape. Of these different inputs, pill shape is the most important and difficult parameter due to its variations. In this paper, we describe a novel technique to accurately detect the complex pharmaceutical pill shapes using measurements derived from a superimposed adaptable ring centered automatically on either the shape’s centroid or its bounding box midpoint determined based on the measurements from two other rings, namely the inner ring and the outer ring. It is shown that the measurements from the overlays of the adaptable ring suffice to successfully classify the shapes of the pills currently in the Pillbox database (U.S. National Library of Medicine, 2014) with an accuracy of 98.7%. Our method demonstrated higher accuracy when compared with Hu-moments on the same data set. Using logistic regression techniques, Hu-moments provided an accuracy of 96.6%. Though developed for the domain of pharmaceutical pill shapes, we discuss how the measurements from the adaptable ring can also be used in other industrial applications to increase the level of accuracy with the help of this real-time less computationally complex method.
Treatment of non-small-cell lung cancer and pharmacogenomics: where we are and where we are going

Purpose of review This review highlights the numerous molecular biology findings in the field of lung cancer with potential therapeutic impact in both the near and distant future. Recent findings Abundant preclinical and clinical data indicate that BRCA1 mRNA expression is a differential modulator of chemotherapy sensitivity. Single nucleotide polymorphisms in the excision repair cross-complementing 1 gene (ERCC1) influence survival with cisplatin-based chemotherapy. For the first time, epidermal growth factor receptor (EGFR) mutations have been shown to predict dramatic responses in metastatic lung adenocarcinomas. The crosstalk between estrogen and EGFR pathways have also been revealed. MicroRNAs control the expression of cognate target genes and predict relapse in surgically resected non-small-cell lung cancer patients. Overexpression of the Wingless-type (Wnt) genes and methylation of Wnt antagonists have been documented in non-small-cell lung cancer. Summary Understanding the relevance of these findings can help to change the clinical practice in oncology towards customizing chemotherapy and targeted therapies, leading to improvement both in survival and in cost-effectiveness.
Sleep duration as a risk factor for the development of type 2 diabetes.

OBJECTIVE Short-term partial sleep restriction results in glucose intolerance and insulin resistance. The purpose of this study was to assess the long-term relationship between sleep duration and the incidence of clinical diabetes. RESEARCH DESIGN AND METHODS A cohort of men from the Massachusetts Male Aging Study without diabetes at baseline (1987-1989) were followed until 2004 for the development of diabetes. Average number of hours of sleep per night was grouped into the following categories: < or =5, 6, 7, 8, and >8 h. Incidence rates and relative risks (RRs) were calculated for the development of diabetes in each sleep duration category. Those reporting 7 h of sleep per night served as the reference group. Multivariate analysis was performed using Poisson regression. RESULTS Men reporting short sleep duration (< or =5 and 6 h of sleep per night) were twice as likely to develop diabetes, and men reporting long sleep duration (>8 h of sleep per night) were more than three times as likely to develop diabetes over the period of follow-up. Elevated risks remained essentially unchanged after adjustment for age, hypertension, smoking status, self-rated health status, education, and waist circumference (RR 1.95 [95% CI 0.95-4.01] for < or =5 h and 3.12 [1.53-6.37] for >8 h). RRs were altered considerably for the two extreme sleep groups when adjusted for testosterone (1.51 [0.71-3.19] for < or =5 h and 2.81 [1.34-5.90] for >8 h), suggesting that the effects of sleep on diabetes could be mediated via changes in endogenous testosterone levels. CONCLUSIONS Short and long sleep durations increase the risk of developing diabetes, independent of confounding factors. Sleep duration may represent a novel risk factor for diabetes.
Overview and History of Statistics for Equity Markets

This article surveys the evolution of stock market trading over a 60-year period. It begins before 1960, when there was no database widely available to conduct a statistical analysis of stock price movements. This changed in the 1960s with the introduction of the Center for Research in Security Prices database. A major finding was the heavy-tailed nature of stock returns. The 1960s also brought major theoretical developments, including the martingale theory of stock price processes and the efficient market hypothesis. This hypothesis prevailed until the 1990s, when the discovery of market anomalies led to statistical arbitrage strategies. We describe the use of modern machine learning methods, such as AdaBoost and random forests, which can combine some of these strategies into an improved trading strategy. The twenty-first century was marked by the rapid evolution of electronic markets and the rise of computer-driven high-frequency trading based on computing technology, low latency access, and limit order.
A multimodality ICA study - integrating genomic single nucleotide polymorphisms with functional neuroimaging data

Genomic experiments encapsulate such rich information that specific analysis tools are needed to take full advantage of the available data. Recently, more attention has been devoted to developing tools to identify the association between genomic variations and phenotypic traits. This paper focuses on understanding an approach called parallel independent component analysis (ICA), while applied to massive microarray data. Parallel ICA is a multivariate approach which can process genotypic and phenotypic data in parallel while emphasizing the relationship between data types. We simulated single nucleotide polymorphism (SNP) array data and functional magnetic resonance imaging data, generating hidden connections between the two modalities. The performance of parallel ICA was compared with a correlation test for a single hypothesis. Our evaluation shows that parallel ICA, in general, is able to extract more accurately the components and connections than the correlation test, in particular for weak linkages. Results also indicate that the ratio of sample size to SNP size should be at least 0.02. However, when the data have a low odds ratio or cases vs. controls ratio, the correlation test provides results reliably, though with lower accuracy.
Use of a functional movement screening tool to determine injury risk in female collegiate athletes.

BACKGROUND Athletes often utilize compensatory movement strategies to achieve high performance. However, these inefficient movement strategies may reinforce poor biomechanical movement patterns during typical activities, resulting in injury. OBJECTIVES This study sought to determine if compensatory movement patterns predispose female collegiate athletes to injury, and if a functional movement screening (FMS™) tool can be used to predict injuries in this population. METHODS Scores on the FMS™, comprised of seven movement tests, were calculated for 38 NCAA Division II female collegiate athletes before the start of their respective fall and winter sport seasons (soccer, volleyball, and basketball). Seven athletes reported a previous history of anterior cruciate ligament reconstruction (ACLR). Injuries sustained while participating in sport activities were recorded throughout the seasons. RESULTS The mean FMS™ score and standard deviation for all subjects was 14.3±1.77 (maximum score of 21). Eighteen injuries (17 lower extremity, 1 lower back) were recorded during this study. A score of 14/21 or less was significantly associated with injury (P=0.0496). Sixty-nine percent of athletes scoring 14 or less sustained an injury. Odds ratios were 3.85 with inclusion of all subjects, and 4.58 with exclusion of ACLR subjects. Sensitivity and specificity were 0.58 and 0.74 for all subjects, respectively. A significant correlation was found between low-scoring athletes and injury (P=0.0214, r=0.76). DISCUSSION A score of 14 or less on the FMS™ tool resulted in a 4-fold increase in risk of lower extremity injury in female collegiate athletes participating in fall and winter sports. The screening tool was able to predict injury in female athletes without a history of major musculoskeletal injury such as ACLR. CONCLUSION Compensatory fundamental movement patterns can increase the risk of injury in female collegiate athletes, and can be identified by using a functional movement screening tool.
Starter packs versus full prescription of antiretroviral drugs for postexposure prophylaxis: a systematic review.

BACKGROUND The provision of starter packs for human immunodeficiency virus postexposure prophylaxis (PEP) is practiced in many settings to facilitate rapid initiation by nonexperts and encourage adherence. However, the impact of starter packs on PEP completion rates has not been systematically assessed. We systematically reviewed the evidence on outcomes associated with starter packs for PEP compared to full prescriptions. METHODS Four databases and 2 conference abstract sites were searched up to December 2013; this search was updated in 1 database in June 2014. PEP completion rates, stratified by prescribing practice, were pooled using random-effects meta-analysis. RESULTS Fifty-four studies provided data on 11 714 PEP initiations. Thirty-seven studies, including 3 randomized controlled trials (RCTs) and 34 observational cohorts, provided information on starter packs (although none of the RCTs specifically assessed starter packs), and 17 studies, including 2 RCTs and 15 observational cohorts, provided information on full prescriptions. Overall, outcomes were better when participants were offered a full 28-day course of PEP at initial presentation to healthcare, with fewer refusals (11.4% [95% confidence interval {CI}, 5.3%-17.5%] vs 22% [95% CI, 16.7%-28.1%]) and higher completion rates (70% [95% CI, 56.7%-77.3%] vs 53.2% [95% CI, 44.4%-62.2%]). More than a quarter (28% [95% CI, 21.4%-34.5%]) of individuals provided with a PEP starter pack failed to return for their subsequent appointment and therefore defaulted prior to receiving a full course of PEP. The quality of the evidence overall was rated as very low. CONCLUSIONS The findings of this review suggest that starter packs do not improve adherence to PEP and may result in lower adherence and completion rates.
World report on child injury prevention

In less than a year, the World Health Organization (WHO) and the United Nations Children’s Fund will release the first ever World report on child injury prevention . It is expected that the report will become a milestone in the child injury prevention field, and will provide an opportunity to focus attention on the issue and generate additional action on the part of governments and their partners. Readers of Injury Prevention are already contributing to the development of the report and can play an important role in its launch and follow-up. Child injuries are a global public health problem. According to the WHO’s Global Burden of Disease data, around 875 000 children under the age of 18 years died as a result of injury or violence in 2002. Injuries are a leading cause of death for all children after their first birthday. Beyond the fatalities, for every child who dies, there are several thousand children who live on with varying degrees of disability. For all the main …
THE ROLE OF DISTRIBUTIVE JUSTICE, PROCEDURAL JUSTICE, BUDGETARY GOAL COMMITMENT AND JOB RELEVANT INFORMATION IN MEDIATING EFFECT OF BUDGETARY PARTICIPATION ON MANAGERIAL PERFORMANCE

Accountability and performance transparency is an important aspect for public sector organizations as an embodiment of the obligations of public or governmental organizations in accounting for the success / failure of program implementation. The Government is obliged to make accountability report in the form of Performance Report of Government Institution. The inconsistency of the study results prompted the authors to reexamine the effect of budgetary participation on managerial performance with distributive justice, procedural fairness, commitment to budget objectives and job-related information as a mediating variable. In implementing all of its obligations to manage funds from the community in a transparent and accountable manner, the government prepares an activity budget. The level of achievement of program activities in the Work and Budgeting Planning (RKA) is strongly influenced by budgetary participation.
Older consumers’ perceptions of functional foods and non-edible health-enhancing innovations

Increasing interest in health and well-being is likely to drive a growth in demand for products that have positive effects on health. Consumers' acceptance of and willingness to buy functional foods has been widely studied, but there has not been research on consumers' attitudes towards innovative non-edible products with health effects. This study examines how older consumers perceive functional foods and novel non-edible health-enhancing products, how willing they are to purchase such products, and how health orientation influences their views. As an example of a ‘radical' innovation, consumers' acceptance of rubbing their hands in a specific soil-based mixture to modulate the immune system is explored. The research material, 13 thematic interviews, was collected in Lahti region, Finland, in 2015. The study indicates that the older consumers' market is not homogeneous. Based on a qualitative, in-depth approach, the study distinguishes four consumer segments with different lay understandings of health and attitudes towards health-enhancing products, which influence people's willingness to purchase such products. The segments are health-seeking consumers, cautious consumers, critical consumers, and natural health consumers. Various motives and barriers for using products with health claims are also identified. The case of rubbing hands in organic soil-based mixture indicates the difficulty of predicting which consumer segment will first adopt this kind of ‘radical' innovation. The results highlight that the credence qualities of a novel product must be communicated and advertised before entering the market while also taking into account the sensory properties of the product. ‘Radical innovations' must be in a form that consumers can easily accept. This article is protected by copyright. All rights reserved.
The Role of Social Work in Providing Mental Health Services and Care Coordination in an Urban Trauma Center Emergency Department.

OBJECTIVE This study examined the role of emergency department (ED) social workers and identified predictors of receipt of social work services and length of ED stay. METHODS Comprehensive reviews were conducted of medical records of all patients (N=49,354) treated in a level 1 trauma center ED from January 1, 2012, to March 31, 2013. Content analysis of chart notes was used to categorize the types of social work services provided. Poisson regression was used to assess associations between demographic and clinical characteristics, receipt of social work services, and length of ED stay. RESULTS Social work services were provided to 18,532 (38%) patients. Most were mental health services (54%), followed by care coordination (31%) and material support or other referrals (15%). Patients seen by social workers had complex presentations, involving mental disorder diagnoses (18%), substance use disorder diagnoses (29%), comorbid diagnoses (32%), and injuries (51%); a quarter of patients had multiple ED visits (26%). In adjusted regression analysis, females (relative risk [RR]=1.15), patients not discharged home (RR=1.44), and those with two or more comorbid diagnoses (RR=1.80), injuries due to assault (RR=1.37), and traumatic brain injury (RR=1.20) were more likely to receive social work services. Such services were associated with an increased length of ED stay (RR=1.34). CONCLUSIONS Social workers provided services to patients with multifaceted needs resulting from complex presentations. Provision of social work services modestly increased length of ED stay. Triage algorithms are needed to target efficiencies, systematize provision of ED social work services, and improve access to services for all patients.
The relative age effect in a professional football club setting

Abstract The relative age effect is an uneven distribution of birth date favouring subjects born in the initial months of a selection year. This study compared the birth-date distributions between several subgroups of Basque football players to identify whether the relative age effect is influenced by age and/or skill level. The study comprised 13,519 players including 114 senior professionals from the Spanish league's AC Bilbao over 21 seasons; over the season 2005–2006, it comprised elite youth (n = 189) from the same club's academy; regional youth (n = 4382) U11–U14 locally federated players; school youth (n = 8834) U10–U11 locally registered school district players. Differences between the observed and expected birth-date distributions were tested based on data from the general Basque male population. Significant chi-square values were followed up by calculating odds ratios and 95% confidence intervals (CI) for the quartile and half-year distributions to examine subgroup differences in the relative age effect. Birth-date distributions of all groups of players showed a significant bias towards early birth in the selection year compared with the reference population (senior, χ2 3 = 24.4, P < 0.001; elite youth, χ2 3 = 59.1, P < 0.001; regional youth, χ2 3 = 41.4, P < 0.001; school youth, χ2 3 = 40.9, P < 0.001). Between-group comparison revealed that the relative age effect incidence progressively increased with a higher level of involvement in youth football. This bias represents a significant loss of potential youth football talent.
An Examination of Training Design Strategies in a Pay-For-Performance Appraisal System Online Workshop

ABSTRACT The purpose of this study was to examine the design of an online training program about pay-for-performance systems for municipal agencies. The effects of two training design strategies, discussion groups and multiple-formatted content, on participants’ declarative knowledge were examined. The moderating role of experience with technology, technology self-efficacy, and several individual characteristic variables were also examined. Participants for the study were adult learners from four undergraduate courses. Analyses indicated that there were significant differences between an online training workshop with discussion group activities and an online training workshop without discussion groups with regard to participants’ declarative knowledge. Findings from the study are discussed.