Miracle-dz/UniFAR-FTUs huggingface dataset:
CD133 expressionand clinicopathologic significance in benign and malignant breast lesions.

BACKGROUND/OBJECTIVE CD133 is the molecular marker of normal stem cells and progenitor cells and also confirmed as a marker for cancer stem cells in various tumors. The aim of this study is to examine the expression of CD133 and assess its clinicopathologic significance in benign and malignant breast lesions. METHODS We analyzed the distribution of CD133 positive cells in breast usual ductal hyperplasia, atypical ductal hyperplasia (ADH), breast ductal carcinoma in situ (DCIS), and invasive breast carcinomas. We then explored the relationship between the CD133 expression and clinicopathologic features using immuno-histochemical staining. RESULTS We found that CD133 is not expressed in the cells of normal breast tissue, but the expression rate increased with progression of lesions from usual hyperplasia, through atypical ductal hyperplasia, ductal carcinoma in situ and invasive carcinoma. The positive expression rate of CD133 in breast invasive ductal carcinoma correlated to histological grade, cancer stage, nodal status, metastasis, recurrence, event-free survival and overall survival. There was no significant correlation between CD133 expression and factors such as age, postmenopausal status, histological type, tumor size, estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 expression. CONCLUSION CD133 may play an important role in the occurrence and development of breast cancer. CD133 positive breast cancer cells are closely related to invasiveness and its expression may predict a poor prognosis.
Network Efficiency Mediates the Relationship Between Vascular Burden and Cognitive Impairment

Background and Purpose— Cerebrovascular disease contributes to age-related cognitive decline, but the mechanisms underlying this phenomenon remain incompletely understood. We hypothesized that vascular risk factors would lead to cognitive impairment through the disruption of brain white matter network efficiency. Methods— Participants were 19 346 neurologically healthy individuals from UK Biobank that underwent diffusion MRI and cognitive testing (mean age=62.6). Global efficiency, a measure of network integration, was calculated from white matter networks constructed using deterministic diffusion tractography. First, we determined whether demographics (age, sex, ethnicity, socioeconomic status, and education), vascular risk factors (hypertension, hypercholesterolemia, diabetes mellitus, smoking, body mass index), and white matter hyperintensities were related to global efficiency using multivariate linear regression. Next, we used structural equation modeling to model a multiple regression. The dependent variable was a latent cognition variable using all cognitive data, while independent variables were a latent factor including all vascular risk factors (vascular burden), demographic variables, white matter hyperintensities, and global efficiency. Finally, we used mediation analysis to determine whether global efficiency explained the relationship between vascular burden and cognition. Results— Hypertension and diabetes mellitus were consistently associated with reduced global efficiency even after controlling for white matter hyperintensities. Structural equation models revealed that vascular burden was associated with cognition (P=0.023), but not after adding global efficiency to the model (P=0.09), suggesting a mediation effect. Mediation analysis revealed a significant indirect effect of global efficiency on cognition through vascular burden (P<0.001), suggesting a partial mediation effect. Conclusions— Vascular burden is associated with reduced global efficiency and cognitive impairment in the general population. Network efficiency partially mediates the relationship between vascular burden and cognition. This suggests that treating specific risk factors may prevent reductions in brain network efficiency and preserve cognitive functioning in the aging population.
Recyclable Superhydrophobic, Anti-moisture Activated Carbon Pellets for Air and Water Purification.

Activated carbon (AC) is a low-cost, highly porous material with large internal surface areas. They are highly efficient to absorb moisture and a variety of chemical pollutants. Therefore, it has been widely used in air and water purification. However, the strong affinity to moisture often dominates, thus limiting AC's adsorption capacity of other pollutants in a humid environment and reducing its overall lifetime. In the study, superhydrophobic and anti-moisture activated carbon (SA-AC) pellets are fabricated through one-step modification of commercially available AC with a solution consisting of superhydrophobic silica nanoparticles. The SA-AC pellets exhibit excellent water-repellency with a static water contact angle reaching 160.3°. More importantly, they are moisture-resistant and air permeable. Therefore, they preferably adsorb organic gases at humid conditions. The absorbed organic vapor can be released when they are transferred back to dry atmosphere, for example, releasing approximately 35% of absorbed ethanol. The recoverability significantly reduces energy requirement compared to calcination or conventional extraction. Great adsorption capacity of organic dyes such as methylene blue, removal of oil-in-water microemulsions, and recyclability of SA-AC pellets are demonstrated. The morphology of the microporous structures of the SA-AC pellets is characterized against processing conditions, surface functional groups and hierarchical structures tailored by the deposition of low-surface-energy silica nanoparticles. The resulting micro/sub-micropores on the pellet surface promotes droplet condensate, thus, displaying greater damp-proof performance than those treated by traditional modification. The study here presents a promising alternative for the efficient purification on large-scale air/water treatment.
Systemic Sarcoidosis Associated with Certolizumab Pegol Treatment for Rheumatoid Arthritis: A Case Report and Review of the Literature

A 69-year-old woman presented with appetite loss, fatigue, and a low-grade fever. She had been receiving certolizumab pegol for rheumatoid arthritis for six years. Computed tomography of the chest showed multiple micronodules in both lungs and bilateral hilar and mediastinal lymphadenopathy. An ophthalmic examination showed the findings of uveitis. Lymphocytosis with an increased CD4/CD8 ratio was seen in the bronchoalveolar lavage fluid. Video-assisted thoracoscopic biopsy specimens obtained from the right lung and a right hilar lymph node showed noncaseous epithelioid cell granulomas. Anti-tumor necrosis factor-α-induced sarcoidosis was diagnosed, and she was successfully treated with cessation of certolizumab pegol and systemic corticosteroid therapy.
Omega-3 index in 2018/19

The omega-3 index, the percentage of EPA plus DHA in erythrocytes (measured by standardised analysis), represents a human body's status in EPA and DHA. An omega-3 index is measured in many laboratories around the world; however, even small differences in analytical methods entail large differences in results. Nevertheless, results are frequently related to the target range of 8–11 %, defined for the original and scientifically validated method (HS-Omega-3 Index®), raising ethical issues, and calling for standardisation. No human subject has an omega-3 index <2 %, indicating a vital minimum. Thus, the absence of EPA and DHA cannot be tested against presence. Moreover, clinical events correlate with levels, less with the dose of EPA and DHA, and the bioavailability of EPA and DHA varies inter-individually. Therefore, the effects of EPA and DHA are difficult to demonstrate using typical drug trial methods. Recent epidemiologic data further support the relevance of the omega-3 index in the cardiovascular field, since total mortality, cardiovascular mortality, cardiovascular events such as myocardial infarction or stroke, or blood pressure all correlate inversely with the omega-3 index. The omega-3 index directly correlates with complex brain functions. Compiling recent data supports the target range for the omega-3 index of 8–11 % in pregnancy. Many other potential applications have emerged. Some, but not all health issues mentioned have already been demonstrated to be improved by increasing intake of EPA and DHA. Increasing the omega-3 index into the target range of 8–11 % with individualised doses of toxin-free sources for EPA and DHA is tolerable and safe.
Influence of prévious sexual experience and post‐emergence rearing conditions on the mating behavior of Chryseida bennetti

Experiments were carried out to study the possible effects of a (first) sexual experience and prior rearing conditions on the subsequent sexual behavior of Chryseida bennetti (Hymenoptera: Eurytomidae), an ectoparasitoid of the bean weevil Acanthoscelides obtectus (Say) (Coleoptera: Bruchidae). A clear reduction in latency before male courtship was observed in experienced males. Multiple matings were performed both by naive and experienced males. A tendency to reduce the post‐mating courtship behavior duration was observed in experienced males, although this reduction was not significant. Rearing conditions also seem to influence the mating behavior of this species: the number of copulations (with the same female) was reduced when males were reared in groups. On the contrary, isolated males performed multiple matings with both grouped and isolated females, although they mated 3 times only with isolated ones. Again, a reduction of the duration of the post‐mating courtship behavior was observed both in grouped males and grouped or isolated females. It seems likely that males that have been reared in groups benefit from a certain influence of social experience that is reflected on their later sexual behavior.
Movements, activity patterns and habitat use of feral pigs (Sus scrofa) in a tropical habitat.

Movements, activity patterns and habitat use of feral pigs were studied in a tropical woodland habitat by radio-telemetry, live-trapping and hunter returns. The mean aggregate home-range size was 33.5 km2 for boars and 24.1 km2 for sows. Feral pigs were rather sedentary, with no tendency to disperse great distances from their initial home ranges. Pigs were most active at night, with peaks of activity in the late afternoon and early morning. Pigs preferentially used the riparian vegetation strip bordering major rivers, and grain crops, when available. The implications for the management of pigs are discussed.
A simple blanch‐dry process for lipoxygenase inactivation in soybean cotyledons

Summary Full-fat flour from unblanched soybeans develops a beany flavour during milling due to lipoxygenase activity; the flour also becomes bitter during storage. The minimum thermal treatment necessary to inactivate lipoxygenase in soybeans before milling was determined. Soybeans were dehulled and cotyledons blanched in water between 80 and 99.3°C. Water blanching for 3 min at 99.3°C was necessary when blanched cotyledons were subsequently sun dried, and the flour had a nitrogen solubility index (NSI) of 37.8% and residual trypsin inhibitor activity (TIA) of 64.2%. Only 1.5 min blanching was necessary to inactivate lipoxygenase in soy cotyledons if they were dried subsequently at 60°C; NSI of this flour was 32.7%, with 44.7% residual TIA.
Evolution of Suites of Traits in Response to Environmental Stress

Traits that enable plants to exploit low-resource environments (e.g., slow tissue turnover, low transpiration rate, high root: shoot ratio, and high concentrations of plant defenses against pathogens and herbivores) are physiologically linked to key growth-related traits (low rates of photosynthesis, nutrient uptake, and growth). Similar suites of traits occur as both phenotypically plastic and evolutionary responses to stress. We suggest that a genetic change in a switch or underlying trait that turns on this stress resistance syndrome (SRS), which causes it to be expressed over a wider range of environmental circumstances, would effectively convert a high-resource genotype into one that is more stress-tolerant. Because of physiological linkages between growth-related traits and the SRS, any heritable change in a key growth-related trait will pleiotropically affect the SRS. Therefore, heritable changes in these key growth-related traits could be accompanied by evolution of the entire SRS. Evidence for this hypothesis comes from single-gene mutants that differ in many stress-related traits, rapid evolution of metaltolerant populations that are broadly stress-resistant, and consistent patterns of traits in species along gradients in resource availability. Similar evolutionary patterns occur in many animal taxa, which suggests that it is a general evolutionary phenomenon. We suggest that rapid evolution in response to changing environmental stress may allow many short-lived species to respond to human-induced environmental change and provide opportunities to develop stress-resistant crops. However, the time lag between generations of long-lived species that dominate most natural vegetation may not allow mature individuals of these species to keep pace with rapid global change
Long‐distance regressive signaling in neural development and disease

Nervous system development proceeds via well‐orchestrated processes involving a balance between progressive and regressive events including stabilization or elimination of axons, synapses, and even entire neurons. These progressive and regressive events are driven by functionally antagonistic signaling pathways with the dominant pathway eventually determining whether a neural element is retained or removed. Many of these developmental sculpting events are triggered by final target innervation necessitating a long‐distance mode of communication. While long‐distance progressive signaling has been well characterized, particularly for neurotrophic factors, there remains relatively little known about how regressive events are triggered from a distance. Here we discuss the emergent phenomenon of long‐distance regressive signaling pathways. In particular, we will cover (a) progressive and regressive cues known to be employed after target innervation, (b) the mechanisms of long‐distance signaling from an endosomal platform, (c) recent evidence that long‐distance regressive cues emanate from platforms like death receptors or repulsive axon guidance receptors, and (d) evidence that these pathways are exploited in pathological scenarios.
The millipedes collected by the Museum "La Specola" on Madagascar 1989/1991, with the description of three new species of giant pill-millipedes (Diplopoda, Sphaerotheriida, Arthrosphaeridae)

Abstract A large collection of millipedes (Diplopoda) from Madagascar, belonging to the Museum “La Specola” in Florence, Italy were investigated. The collection includes three new species of the giant pill-millipede genus Zoosphaerium Pocock, 1895 which are described here as Zoosphaerium mangabe Wesener, sp. nov., Z. bartolozzii Anilkumar & Wesener, sp. nov., and Z. taitii Anilkumar & Wesener, sp. nov., all belonging to the Z. coquerelianum species group. The latter two are currently only known from a single site. Other specimens belonging to eight orders (Polyxenida, Sphaerotheriida, Polyzoniida, Siphonophorida, Chordeumatida, Polydesmida, Spirobolida, and Spirostreptida) are listed. Three tropical tramp species, Pseudospirobolellus avernus (Butler, 1876), Glyphiulus granulatus Gervais, 1847, and Chondromorpha xanthotricha (Attems, 1898) are recorded for the first time from Madagascar. New locality data is provided for Zoosphaerium neptunus (Butler, 1872), Z. villosum Wesener & Sierwald, 2005, Z. blandum (de Saussure & Zehntner, 1897), Sphaeromimus musicus (de Saussure & Zehntner, 1897), Rhinotus purpureus (Pocock, 1894), Hylekobolus andasibensis Wesener, 2009, Aphistogoniulus infernalis Wesener, 2009, Ostinobolus rufus Wesener, 2009, Ostinobolus subterraneus Wesener, 2009, Dactylobolus bivirgatus (Karsch, 1881), and Eumekius antimena (de Saussure & Zehntner, 1901).
Advances in the molecular classification of pediatric brain tumors: a guide to the galaxy

Central nervous system (CNS) tumors are the most common solid tumor in pediatrics, accounting for approximately 25% of all childhood cancers, and the second most common pediatric malignancy after leukemia. CNS tumors can be associated with significant morbidity, even those classified as low grade. Mortality from CNS tumors is disproportionately high compared to other childhood malignancies, although surgery, radiation, and chemotherapy have improved outcomes in these patients over the last few decades. Current therapeutic strategies lead to a high risk of side effects, especially in young children. Pediatric brain tumor survivors have unique sequelae compared to age‐matched patients who survived other malignancies. They are at greater risk of significant impairment in cognitive, neurological, endocrine, social, and emotional domains, depending on the location and type of the CNS tumor. Next‐generation genomics have shed light on the broad molecular heterogeneity of pediatric brain tumors and have identified important genes and signaling pathways that serve to drive tumor proliferation. This insight has impacted the research field by providing potential therapeutic targets for these diseases. In this review, we highlight recent progress in understanding the molecular basis of common pediatric brain tumors, specifically low‐grade glioma, high‐grade glioma, ependymoma, embryonal tumors, and atypical teratoid/rhabdoid tumor (ATRT). © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
GENETIC CONSEQUENCES OF REINTRODUCTIONS: AN EXAMPLE FROM OREGON PRONGHORN ANTELOPE (ANTILOCAPRA AMERICANA)

Abstract In 1969, 17 pronghorn were reintroduced onto Umatilla Army Base in Oregon with no subsequent translocations or immigration into this fully enclosed area. We explored the genetic signature this event left on the population using a combination of microsatellite genotypes and mitochondrial DNA (mtDNA) sequencing data of this population. We compared the present day Umatilla herd to its source population and to a southeastern Oregon population. We found the reintroduced population had sharply lower genetic diversity compared to its source despite its rapid increase in population size following the initial founding event. It is likely the observed loss of diversity and the significant differentiation observed between the Umatilla herd and its source was a function of the low number of founders and stochastic losses of diversity in subsequent generations. We observed significant haplotypic and genotypic differentiation between the reintroduced population and its source (GST = 0.063, FST = 0.078, p < 0.001) that was approximately 3.5 times that found between the source and the southeastern population (GST = 0.018, FST = 0.021, p < 0.001). Moreover, 2 rare alleles in the source population were found in high frequency in the translocated population. The founding effect, stochastic shifts in allele frequencies each generation, restricted gene flow, and variance in the segregation of alleles related to a polygamous mating system have contributed to the significant differentiation observed between the Umatilla herd and its source. The results of this study can be applied directly to the management of ongoing translocation activities within Oregon.
Transforming Growth Factor-β Signaling during Epithelial-Mesenchymal Transformation: Implications for Embryogenesis and Tumor Metastasis

The molecular mechanisms of epithelial-mesenchymal transformation (EMT) have long been studied to gain a greater understanding of this distinct change in cellular morphology. Early studies of the developing embryo have designated the involvement of Wnt signaling in EMT, through an activated complex of the lymphoid-enhancing factor-1 (LEF-1) transcription factor and the cell adhesion molecule β-catenin. However, more recent studies have implicated a significant role of the transforming growth factor-β (TGF-β) in causing EMT in both development and pathology. The ability of TGF-β isoforms to signal through a variety of molecules such as Smads, phosphatidylinositol 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) creates an incredible complexity as to their role in this transition. Here we assess the biochemical signaling pathways of TGF-β and their potential cross-interaction with traditional Wnt signaling molecules to bring about EMT during embryogenesis and tumor metastasis.
Selling function: the advertising of sugar-containing beverages on Australian television.

Reducing population consumption of sugar-containing beverages has become a public health priority in many countries due to causal evidence between high consumption, weight gain and non-communicable diseases. This study aims to explore how sugar-containing beverages are associated with health and wellness in television advertisements. Our sample consisted of all televised advertisements from sugar-containing beverage manufacturers aired on free-to-air television from one Australian network (four channels) in 2016 (n = 30 unique advertisements). We transcribed advertisements for audio and visual information. We analysed data inductively using methods from thematic, discourse and multi-modal analysis. Advertisements for sugar-containing beverages reflected both traditional (physical health and reduced risk of disease) and broader (wellbeing) conceptualizations of health. Beverages were positioned in advertisements as contributing a functional role to promote and enhance health and wellbeing within the physical, mental and social domains. Beverages were advertised as correcting suboptimal states of being to achieve desirable outcomes, including relaxation, increased resistance to disease, enhanced performance, better cognitive functioning and improved social connections. Positioning beverages within a wider conceptualization of health and wellbeing aligns with how health and nutrition are increasingly being understood and sought out by consumers, creating increased opportunities for the marketing of sugar-containing beverages as 'healthy'.
Detection of Compounds Formed through the Reaction of Malvidin 3-Monoglucoside and Catechin in the Presence of Acetaldehyde

The interaction between catechin and malvidin 3-monoglucoside in the presence of acetaldehyde was studied in model solutions. The initial formation of two pigments (I and II), which later evolved to more condensed structures, was observed. Evidence was found that for these pigments to be formed, catechin should first react with acetaldehyde and the resulting adduct later condenses with anthocyanin ; it is proposed that pigments I and II are two enantiomeric structures of the catechin-(8→)-acetyl-(→8)-anthocyanin dimer. For their formation, a relatively acidic pH is necessary ; this is attributed to the demand that the acetaldehyde should be in cationic form for condensation to occur. Condensation among catechin units involving acetaldehyde was also seen. Minor amounts of substances from the degradation of anthocyanin were detected, indicating that in the presence of acetaldehyde it is basically condensation and not degradation of the anthocyanin that occurs.