Miracle-dz/UniFAR-FTUs huggingface dataset:
The Learning Curve for Shared Decision-making in Symptomatic Aortic Stenosis.

Importance Shared decision-making (SDM) is widely advocated for patients with valvular heart disease yet is not integrated into the heart team model for patients with symptomatic aortic stenosis. Decision aids (DAs) have been shown to improve patient-centered outcomes and may facilitate SDM. Objective To determine whether the repeated use of a DA by heart teams is associated with greater SDM, along with improved patient-centered outcomes and clinician attitudes about DAs. Design, Setting, and Participants This mixed-methods study included a nonrandomized pre-post intervention and clinician interviews. It was conducted between April 30, 2015, and December 7, 2017, with quantitative analysis performed between January 12, 2017, and May 26, 2017, within 2 academic medical centers in northern New England among 35 patients with symptomatic aortic stenosis who were at high to prohibitive risk for surgery. The qualitative analysis was performed between August 6, 2018, and May 7, 2019. The Severe Aortic Stenosis Decision Aid was delivered by 6 clinicians, with patients choosing between transcatheter aortic valve replacement and medical management. Main Outcomes and Measures Clinician SDM performance was measured using the Observer OPTION5 scale with dual-independent coding of audiotaped clinic visits. Previsit and postvisit surveys measured the patient's knowledge, satisfaction, and decisional conflict. Audiotaped clinician interviews were coded, and qualitative thematic analysis was performed. Results Six male clinicians and 35 patients (19 of 34 women [55.9%; 1 survey was missing]; mean [SD] age, 85.8 [7.8] years) participated in the study. Shared decision-making increased stepwise with repeated use of the DA (mean [SD] Observer OPTION5 scores: usual care, 17.9 [7.6]; first use of a DA, 60.5 [30.9]; fifth use of a DA, 79.0 [8.4]; P < .001 for comparison between usual care and fifth use of DA). Multiple uses of the DA were associated with increased patient knowledge (mean difference, 18.0%; 95% CI, 1.2%-34.8%; P = .04) and satisfaction (mean difference, 6.7%; 95% CI, 2.5%-10.8%; P = .01) but not decisional conflict (mean [SD]: usual care, 96.0% [9.4%]; first use of DA, 93.8% [12.5%]; fifth use of DA, 95.0% [11.2%]; P = .60). Qualitative analysis of clinicians' interviews revealed that clinicians perceived that they used an SDM approach without DAs and that the DA was not well understood by elderly patients. There was infrequent values clarification or discussion of stroke risk. Conclusion and Relevance In a mixed-methods pilot study, use of a DA for severe aortic stenosis by heart team clinicians was associated with improved SDM and patient-centered outcomes. However, in qualitative interviews, heart team clinicians did not perceive a significant benefit of the DA, and therefore sustained implementation is unlikely. This pilot study of SDM clarifies new research directions for heart teams.
Flow Rate and Low Hematocrit Measurements for $In Vitro$ Blood Processing With Doppler Ultrasound

In vitro techniques for the processing of flowing blood and its components have recently emerged from microfluidics. The blood flow rate and hematocrit are two keys parameters to monitor for guaranteeing the reliability of these techniques. But, there is a lack of monitoring methods adapted to low flow rates and small tubing. In this study, we exploit minimization approaches of continuous Doppler measurements to survey the blood flow rate. Combined with a packing factor model, we also estimate hematocrit from the Doppler spectrum. The presented method is implemented with a continuous-wave (CW) Doppler probe mounted on a 3D-printed support. The accuracy of the flow rate was measured in the range from 0.5 to 1.5 mL/min. For each of four different blood bags, hematocrit in the range under 8% was estimated from the Doppler spectrum using a packing factor model derived from the other three bags. Flow rate estimation shows a mean measurement error under 3% for a measurement time of 2 s. The mean error is still under 5% for a measurement time of 0.5 s. Hematocrit estimation for the four blood bags shows errors of 1.4%, 1.1%, 0.67%, and 0.70% Hct for a measurement time of 5 s. The versatility and simplicity of the method make it highly valuable for in vitro blood processing, in particular for low hematocrit blood fractionation techniques derived from microfluidics, as it can be performed through sterile tubing.
Fetal and Maternal Responses to Dexmedetomidine Intrathecal Application During Cesarean Section: A Meta-Analysis

Background Intrathecal dexmedetomidine (DEX) can improve the blockade of spinal anesthesia, but there is no clear conclusion on whether it has an effect on the fetus during cesarean section. Our meta-analysis evaluated the safety and efficacy of intrathecal DEX in cesarean delivery. Material/Methods We searched Cochrane, Embase, PubMed, and CBM for eligible studies, and used the Revised Cochrane Risk of Bias Tool (RoB 2.0) to assess the risk of bias of each study. RevMan was used for statistical analyses. We have registered this meta-analysis on PROSPERO (CRD42019120995). Results The meta-analysis included 10 RCTs, but only 5 were prospectively registered. The results of preregistration studies, including the 1- or 5-min Apgar score (mean difference [MD], −0.03; 95% confidence intervals [CI], −0.16 to 0.10; P=0.64 or MD, 0.00; 95% CI, −0.09 to 0.09; P=1), the umbilical arterial oxygen or carbon dioxide partial pressure (MD, 0.90; 95% CI, −4.92 to 6.72; P=0.76 or MD, 1.20; 95% CI, −2.06 to 4.46; P=0.47), and the cord blood pH (MD, −0.01; 95% CI, −0.05 to 0.03; P=0.72), showed that intrathecal DEX had no significant difference in neonatal outcomes compared with placebo. In maternal outcomes, intrathecal DEX significantly prolonged postoperative pain-free period and reduced the incidence of postoperative shivering, which did not increase spinal anesthesia-associated adverse effects. Conclusions Intrathecal DEX is safe for the fetus during cesarean section and can improve the blockade effects of spinal anesthesia on puerperae.
Sox2 gene regulation via the D1 enhancer in embryonic neural tube and neural crest by the combined action of SOX2 and ZIC2

The transcription factor (TF) SOX2 regulates various stem cells and tissue progenitors via functional interactions with cell type‐specific partner TFs that co‐bind to enhancer sequences. Neural progenitors are the major embryonic tissues where SOX2 assumes central regulatory roles. In order to characterize the partner TFs of SOX2 in neural progenitors, we investigated the regulation of the D1 enhancer of the Sox2 gene, which is activated in the embryonic neural tube (NT) and neural crest (NC), using chicken embryo electroporation. We identified essential TF binding sites for a SOX, and two ZIC TFs in the activation of the D1 enhancer. By comparison of dorso‐ventral and antero‐posterior patterns of D1 enhancer activation, and the effect of mutations on the enhancer activation patterns with TF expression patterns, we determined SOX2 and ZIC2 as the major D1 enhancer‐activating TFs. Binding of these TFs to the D1 enhancer sequence was confirmed by chromatin immunoprecipitation analysis. The combination of SOX2 and ZIC2 TFs activated the enhancer in both the NT and NC. These results indicate that SOX2 and ZIC2, which have been known to play major regulatory roles in neural progenitors, do functionally cooperate. In addition, the recently demonstrated SOX2 expression during the NC development is accounted for at least partly by the D1 enhancer activity. Deletion of the D1 enhancer sequence from the mouse genome, however, did not affect the mouse development, indicating functional redundancies of other enhancers.
Analysis of Strengths, Weaknesses, Opportunities, and Threats (SWOT) for Business of Laboratory Competency Training

This study aims to analyze business opportunity of laboratory competency training and analyze development of the potential factor on the services of laboratory competency training. The subjects of this study are the expert chemical analysts in Bandung. This research method used descriptive qualitative using Strength, Weakness, Opportunity, and Threats (SWOT) analysis and Quantitative Strategic Planning Matrix (QSPM) as a tool to formulate management strategic of the laboratory competency training. The data collection was done through interviews, observation and literature review. The result shows that laboratory competency training is potential to develop a business opportunity in order to improve the competency of chemical analyst. The appropriate management strategies are development subject of training based on user requirement, development services in laboratory competency training, marketing optimization system with digital marketing, facilitation of latest equipment that used in training program, and responsiveness to the changing government policies Keywords—SWOT, QSPM, Competency Laboratory, Chemical
Retention of β-carotene in biofortified sweet potato chips after processing

Consumption of biofortified foods such as sweet potatoes with high content of β-carotene may reduce deficiency of this micronutrient. The development of biofortified sweet potato chips expands the distribution and offers an alternative to the consumption of this product. The aim of this study was to evaluate the thermal blanching methods (steam and in boiling water) in β-carotene retention in the production of dehydrated biofortified sweet potato chips with air circulation at 65°C. The raw material, the chips blanched in steam and in boiling water had a content of β-carotene of 501.86 ± 53.65, 490.23 ± 30.00 and 473.91 ± 11.43 µg g-1 (d.b.) respectively. The retention of β-carotene for steam and boiling water blanching was 97.7 and 94.4% respectively. The blanching conditions followed by drying used in the processing to obtain sweet potato chips were adequate as they resulted in β-carotene high retention.
Expression of miR-760 in cervical squamous cell carcinoma tissues and cells and its effect on malignant biological behaviors of SiHa cells

[摘 要] 目的: 探讨微小RNA(miR)-760在人宫颈鳞状细胞癌(CSCC)组织和细胞中的表达及其对SiHa细胞增殖、凋亡、侵 袭、迁移、EMT影响的分子机制。 方法: 选用2015年4月至2018年8月山东省聊城市妇幼保健院妇科手术切除、经病理确诊的 80例CSCC组织及相应的癌旁组织标本和40例子宫肌瘤切除术获取的正常宫颈组织标本,应用qPCR检测CSCC组织、癌旁组织 和正常宫颈组织、人CSCC细胞系SiHa、HCC94和人宫颈鳞状上皮永生化细胞株H8中miR-760的表达水平,分析miR-760表达与 CSCC患者临床病理特征的相关性。 用脂质体转染法,将miR-760 mimics和NC-mimics质粒分别转染至SiHa细胞,用qPCR检测 SiHa细胞中miR-760的表达,用CCK-8实验和流式细胞术分别检测SiHa细胞增殖能力和凋亡水平,用Transwell实验检测SiHa细 胞的侵袭和迁移能力,WB检测SiHa细胞EMT相关蛋白上皮型钙黏蛋白(E-cadherin)、波形蛋白(vimentin)和神经型钙黏蛋白 (N-cadherin)的表达变化。 用生物学信息法预测FOXA1与miR-760的靶向关系,用双荧光素酶报告基因验证miR-760对FOXA1 的直接靶向调控作用。 结果:CSCC组织中miR-760表达明显低于癌旁组织及正常宫颈组织(均P<0.01),miR-760表达与患者淋 巴结转移和临床分期密切相关(均P<0.01)。 SiHa、HCC94细胞中miR-760的表达明显低于H8细胞(均P<0.01)。 通过转染miR760 mimics上调miR-760表达,能够显著抑制SiHa细胞的增殖能力和侵袭、迁移能力(均P<0.01)、促进其凋亡(P<0.01),并上调Ecadherin的表达(P<0.01)、下调vimentin和N-cadherin的表达(均P<0.01)。 FOXA1是miR-760的直接靶基因(P<0.01),上调miR760表达显著抑制SiHa细胞中FOXA1 mRNA和蛋白的表达(均P<0.05)。 结论:在CSCC组织和细胞中miR-760低表达,其通过 靶向作用FOXA1基因调控SiHa细胞的增殖、侵袭、迁移并促进凋亡,同时影响癌细胞的EMT进程。 [关键词] 宫颈鳞状细胞癌;SiHa细胞;miR-760;FOXA1;增殖;侵袭;迁移;凋亡 [中图分类号] R737.33; R730.2 [文献标识码] A [文章编号] 1007-385X(2019)10-1120-08
Evaluation of the effect of supplementation of Ashwagandha (Withania somnifera) root powder in the broiler’s ration on gut morphology and bacteriology: A review

The global for poultry production experienced leaps and bounces to accommodate rising demand over past few years. On the other hand, popular demand and scientific interest for organic poultry production, particularly feeding with medicinal botanicals, has increased considerably in recent years. Ashwagandha (Withania somnifera) is a well known herb possessing several health benefits. The alkaloids and steroidal lactones (withanolides) are the main constituent found in it. These are responsible for modulating the gut environment of broiler birds which further responsible for better feed digestion and utilization. With use of Ashwagandha in the diet of broiler birds, there is decrease in harmful microflora and increase in beneficial microflora in gut. A positive change was observed in morphometry of gut, which finally lead to better feed utilization and growth performance of broiler birds. The aim of this study was to review research currently being carried out on the Ashwagandha and phytogenics that have been shown to modulate the gut environment, microflora and morphology and special attention is given to the use of herbal plants as poultry feed supplement.
Combined Treatment with Oral Hypoglycemic Agents and Insulin in Longer Run May Lead to Cognitive Derangement Secondary to Hypoglycemia

To determine the risk associated with combined therapy of oral hypoglycemic agents and insulin in the development of cognitive decline secondary to hypoglycemia. The study comprised of two arms, in arm 1 (n=30) diabetic patients on OHA and insulin combined therapy were observed for cognitive derangement based on Mini Cog score (Pearson’s correlation r was calculated between the two)and the patients were also ruled out for hypoglycemia episodes. Similarly, in arm 2(n=30), only OHA therapy patients were evaluated on the same parameters using Pearson’s correlation. Mean Mini Cog scores were found to be 1.79 in patients on combinational therapy of OHA and insulin. In the case of patients only on OHA for diabetes control mean Mini Cog, the score was 2.0. Pearson’s coefficient r 1 between OHA plus insulin duration of therapy in years with Mini Cog score was -0.5831 at a statistically significant p value of 0.0007. While on the other hand, patients only on OHA therapy (in years)were not significantly correlated with Mini Cog scores. (r 2= - 0.0149 ; p value =0.93771). In the arm 1 (OHA + Insulin(n=30)), the average number of hypoglycemia episodes were found to be 2.633 as compared to the OHA only group in which mean hypoglycemia episodes were 0.866. There was a significant difference in the hypoglycemia episodes, as confirmed by the student t-test (4.06368) at a p value = 0.000147. Based on the study findings, combined Treatment with Oral Hypoglycemic agents and insulin in longer run may lead to cognitive derangement secondary to hypoglycemia. *Significance level <0.01, Negative correlations are indicative of lower the values of battery scores higher would be cognitive derangement.
The Role of Governance Interaction with Customer Service in Improving Banking Financial Performance

Customer satisfaction is one of the most important factors in business, when it comes to commercial banks, customer satisfaction level differentiates one bank from another, thus measuring customer satisfaction is exceedingly important. Profitable business cannot exist without satisfied customers, especially in service-oriented industries. Customer satisfaction is an important step to gain customer loyalty. The banking corporate governance is known to improve bank financial performance and value, by reducing the level of expropriation of the company’s assets done by the management, while the satisfaction of the external customers leads to retain customers and add new customers. Banking governance regulates the mechanisms and practices of the banking service engines and oriented them towards effective customer’s satisfaction investigation. This lead to wards improved banking financial performance, more of previous studies lack to concepts and tools that are used to transform the ideas and theories of improving the quality of banking performance into actual productive practices. From this point, the study attempts to bridge this gap by disclosure the interactive role of banking governance in effectively linking theory and practice in improving the quality of banking financial performance. The paper problem was summarized with the question: to what extent can be interaction of customer services with corporate governance in improving the banking overall financial performance of the Iraqi commercial banks? The study pursues in the design and synthesis and analysis methods, deductive and inductive approach. The study use the analysis and synthesis supported by theoretical evidence in its theoretical part, and used the analysis and conclusion supported by statistical techniques in its practical part, the study was conducted at the sample of commercial banks at Basra Governorate, the study followed the method of exploratory research, using two tools to collected data, the first tool, checklist to assess the overall performance of the banks in question, the size of the respondent sample was 40 individuals and the second tool is a questionnaire with sample size (60 cases), in the light of the analysis the results, conclusions and recommendations were determined.
The Role of Deferoxamine and Quercetin on The Short Term Chronic Toxicity of Iron on The Pituitary, Ovaries and Uterus of Prepubertal Albino Rats

Iron is an important metal for Hypothalamic-pituitary-gonadal axis. Deferoxamine used as a potent antioxidant plus its chelating function. Quercetin is an effective antioxidant and also reported to have estrogenic activities. The aim of this study was to evaluate the role of deferoxamine and quercetin in the treatment of toxicity induced by short term chronic administration of iron in prepubertal female rats. One hundred and ten rats were divided into 5 groups: Group I : control (40 rats). Group II:(10 rats) injected IP daily with deferoxamine (DFO) (125mg /kg ) for 4 weeks. Group III:( 10 rats ) treated with quercetin (Q) (2g/kg daily) orally for 4 weeks. Group IV:( 10 rats ) received deferoxamine + quercetin for 4 weeks. Group V: (40 rats) subdivided into 4 sub-groups, Va: injected IP daily with Iron dextran (300 mg/kg) for 4 weeks then rats were sacrificed and submitted to biochemical and histopathological examination. Vb: injected intraperitoneally daily with iron dextran for 4 weeks, then received daily intraperitoneal deferoxamine for another 4 weeks. Vc: injected intraperitoneally daily with iron dextran for 4 weeks, then received daily quercetin orally by for another 4 weeks. Vd: injected intraperitoneally daily with iron dextran for 4 weeks, then received daily intraperitoneal deferoxamine + quercetin orally for another 4 weeks. The results showed significant increase in serum iron concentration, ferritin and NTBI and TBARS with significant decrease in serum (LH),(FSH) and estradiol hormones and serum (TAC) values in iron group when compared with other groups accompanied by histopathological changes in pituitary, ovaries and uterus, with marked iron deposits detected by Prussian blue stain and increased expression of caspase 3 . Treatment with deferoxamine or quercetin showed improvement in these parameters which nearly were equally effective. Combined treatment with deferoxamine and quercetin was better than single ones.
When is Capital Enough to Get Female Microenterprises Growing? Evidence from a Randomized Experiment in Ghana

Standard models of investment predict that credit-constrained firms should grow rapidly when given additional capital, and that how this capital is provided should not affect decisions to invest in the business or consume the capital. We randomly gave cash and in-kind grants to male- and female-owned microenterprises in urban Ghana. Our findings cast doubt on the ability of capital alone to stimulate the growth of female microenterprises. First, while the average treatment effects of the in-kind grants are large and positive for both males and females, the gain in profits is almost zero for women with initial profits below the median, suggesting that capital alone is not enough to grow subsistence enterprises owned by women. Second, for women we strongly reject equality of the cash and in-kind grants; only in-kind grants lead to growth in business profits. The results for men also suggest a lower impact of cash, but differences between cash and in-kind grants are less robust. The difference in the effects of cash and in-kind grants is associated more with a lack of self-control than with external pressure. As a result, the manner in which funding is provided affects microenterprise growth.
A routine for the determination of the microstructure of stacking-faulted nickel cobalt aluminium hydroxide precursors for lithium nickel cobalt aluminium oxide battery materials

Stacking faults and interstratification faults in a cobalt- and aluminium-bearing nickel layered double hydroxide used as a precursor for Li(Ni1−x−yCoxAly)O2 battery materials were quantified by a combination of a grid-search approach and a recursive routine for generating and averaging supercells of stacking-faulted layered substances implemented in the TOPAS software.
A new representation of open information extraction in Persian language

Open information extraction is a new technology in the text mining process which is still at the beginning and requires many attempts and considerations for improvement. These attempts includes both the representation and extraction of information. The complication and instability of language intensify the problems of the open information extraction. In this article an advanced representation of information is presented for the Persian language; a representation which can be a favorable cover for the open information extraction by identifying dependency analysis relationships. In the present article, it is tried to reach the feasibility of this representation, the representation correspondence using syntactic labeling, and plausible representation of information extraction. By making this attempts, the threshold for the information extraction goes far beyond its simple epresentation state, which is a tripple. Although this article tries to overally outline the approach of using an advanced representation of information extraction, it specifically investigates the use of this representation in QA systems.
Genomic Selection in Horse Breeding

The aim of this paper was to present the general aspects of genomic selection in horse breeding and also to provide an overview of existing applications in horses breeding, with particular emphasis on the challenges of implementation and long-term use. Based on conducted review, it could be concluded that breeding organizations must convince horse breeders that genomic selection can be a valuable tool to increase selection success either in sports or in other horse breeding. Genomic selection (GS) allows breeders to evaluate the important traits of offspring even before its birth. GS uses genetic markers to test all relevant traits, including those that are currently very difficult to measure, such as disease resistance, meat quality, horse’s crest height, etc. Finally, to establish the relevant genomic selection in individual breeds or breeding types of horses, it is necessary to create a network of collaboration between breeding associations in order to gather all necessary data.
Dynamic Modulation of Human Interactive Robots using Impedance Control

Human-robot interaction is prominently seen in industries, haptics etc. where the underlying objective is to make the robot assistive in nature to the human. A methodology is proposed herein to improve the assistive nature of the robot by reducing the inertia felt by the human. An impedance controller is presented to modulate the dynamics of the manipulator and assign an apparent inertia to the robot. Simulation results with the case study of a five-bar manipulator demonstrate that the required human force is lesser after the implementation of the impedance controller. Furthermore, the kinematics of the five-bar are formulated analytically using a novel computationally less intensive approach. It is also shown that the computation of the proposed kinematics does not suffer at the singularity configurations.