Miracle-dz/UniFAR-FTUs huggingface dataset:
An extension on PROMETHEE based on the typical hesitant fuzzy sets to solve multi-attribute decision-making problem

Purpose The purpose of this paper is to extend the PROMETHEE method under typical hesitant fuzzy information for solving multi-attribute decision-making problem in which there is hesitancy among experts. Design/methodology/approach Different aggregation and distance functions were developed to deal with HFS. But it is rational that different operators applying in existing methods can produce different results. Also, it is difficult for decision makers to select suitable operators. To address the drawback, this paper develops the PROMETHEE method as an outranking approach to accommodate hesitant fuzzy information. Since the proposed method is constructed on the basis of the pair-wise comparisons, it is independent of the aggregation and distance functions. Findings To demonstrate the efficiency and accuracy of the proposed method, the authors provide a numerical example and a comparative analysis. The results indicate that outranking-based methods suggest a better ranking than the aggregation- and distance-based methods. Research limitations/implications The proposed approach does not consider the hesitant fuzzy linguistic information decision-making problem. Practical implications The proposed approach can be applied in many group decision-making problems in which there is hesitancy among experts. Originality/value This paper proposes an extension on PROMETHEE method under hesitant fuzzy information, which has not been reported in the existing academic literature.
Hough-based model for recognizing bar charts in document images

Bar charts are the most basic graphic representation for scientific data in technical and business papers. The objective of bar chart recognition in document image analysis is to extract graphics and text primitives structurally, then to correlate graphic interpretative information with text primitives semantically. This paper proposes a new model for generic bar chart recognition. We first change the image space into the Hough space by applying Hough Transform on the feature points. Then we use hypothesis-testing bar pattern searching algorithm to detect the bar patterns. We also apply a new text primitives grouping algorithm to extract text primitives. Finally, we interpret bar primitives by correlating them with corresponding text primitives like human's visual processing. The results show that the new model can recognize bar charts lying in any orientations, such as slant bar charts, or even hand-drawn bar charts.
MgxZn1-xO/Ag/MgxZn1-xO Multilayers As High-Performance Transparent Conductive Electrodes.

We report on the optical and electrical properties of MgxZn1-xO/Ag/MgxZn1-xO transparent conductive electrodes. The transmittance and sheet resistance of MgxZn1-xO/Ag/MgxZn1-xO multilayers deposited at room temperature were strongly dependent on the thickness and surface morphology of Ag layer. The optical absorption edge of MgxZn1-xO/Ag/MgxZn1-xO showed a blue shift with increasing Mg composition due to the increased band gap of MgxZn1-xO. The Haack figure of merit value of Mg0.28Zn0. 72O/Ag/Mg0.28Zn0. 72O with a 14 nm-thick Ag layer, which has a sheet resistance of 6.36 Ω/sq and an average transmittance of 89.2% at wavelengths in the range from 350 to 780 nm, was 69% higher than that of a ZnO/Ag/ZnO multilayer electrode. These results indicate that MgxZn1-xO/Ag/MgxZn1-xO multilayers, which also show low surface roughness, can be used as highly conductive transparent electrodes in various optoelectronic devices operating over a wide wavelength region.
Safe Care for Pediatric Patients: A Scoping Review Across Multiple Health Care Settings

Children are particularly vulnerable to patient safety concerns due to pediatric-specific and general health care challenges. This scoping review identifies and describes the vulnerabilities of those aged 0 to 18 years to iatrogenic harm in various health care settings. Six databases were searched from 1991 to 2012. Primary studies were categorized using predetermined groupings. Categories were tallied and descriptive statistics were employed. A total of 388 primary studies exploring interventions that improved patient safety, deficiencies, or errors leading to safety concerns were included. The most common issues were medication (189 studies, 48.7%) and general medical (81 studies, 20.9%) errors. Sixty studies (15.5%) evaluated or described patient safety interventions, 206 studies (53.1%) addressed health care systems and technologies, 17 studies (4.4%) addressed caregiver perspectives and 20 studies (5.2%) discussed analytic models for patient safety. Further work is needed to ensure consistency of definitions in patient safety research to facilitate comparison and collation of results.
In silico mutational studies of Hsp70 disclose sites with distinct functional attributes

The Mutation‐Minimization Method (MuMi) to study the local response of proteins to point mutations has been introduced here. The heat shock protein Hsp70 as the test system since it displays features that have been studied in great detail has been used here. It has many conserved residues, serves several different functions on each of its domains, and displays interdomain allostery. For the analysis of spatial arrangement of residues within the protein, the network properties of the wild type (WT) protein as well as its all single alanine residue mutants using MuMi has been investigated. The measures to express the amount of change from the WT structure upon mutation and compare these deviations to find potential critical sites have been proposed. The functional significance of the potential sites to the parameter that uncovers them has been mapped. It was found that sites directly involved in binding were sensitive to mutations and were characterized by large displacements. On the other hand, sites that steer large conformational changes typically had increased reachability upon alanine mutations occurring elsewhere in the protein. Finally, residues that control communication within and between domains reside on the largest number of paths connecting pairs of residues in the protein. Proteins 2015; 83:2077–2090. © 2015 Wiley Periodicals, Inc.
A Ratio Test of Interrater Agreement With High Specificity

Existing tests of interrater agreements have high statistical power; however, they lack specificity. If the ratings of the two raters do not show agreement but are not random, the current tests, some of which are based on Cohen’s kappa, will often reject the null hypothesis, leading to the wrong conclusion that agreement is present. A new test of interrater agreement, applicable to nominal or ordinal categories, is presented. The test statistic can be expressed as a ratio (labeled QA, ranging from 0 to infinity) or as a proportion (labeled PA, ranging from 0 to 1). This test weighs information supporting agreement with information supporting disagreement. This new test’s effectiveness (power and specificity) is compared with five other tests of interrater agreement in a series of Monte Carlo simulations. The new test, although slightly less powerful than the other tests reviewed, is the only one sensitive to agreement only. We also introduce confidence intervals on the proportion of agreement.
Optimal splitting technique for remote sensing satellite imagery data

Target detection in satellite images requires multilevel processing. One of the important levels of processing is image segmentation. In this, a gray level image is segmented into some limited number of classes. One of these segmentation techniques is clustering. Cluster analysis is the formal study of algorithms and methods for grouping. Most of the K-means class of methods start with some initial seed points and grow cluster around them. There exists two basic problems related to all seed based techniques - choice of appropriate initial seed points and single seed based techniques are not effective of more complex and elongated shape. Any elongated or non-convex cluster can be considered as the union of a few distinct hyper-spherical clusters. A multi-seed clustering method based on the border points proposed by Chaudhuri and Chaudhuri but, the border point extraction from remote sensing satellite imagery (RSSI) and noisy data is a difficult job. RSSI data has three basic characteristics - non-parametric, highly-overlapping and non-Gaussian. The proposed seed-point detection technique is statistical based and can solve the non-parametric as well as non-Gaussian problems. Also it focuses on the non-Gaussian field as the union of several Gaussian fields. Each seed point has a core set. After finding the seed points, an initial splitting technique (IST) based on the min-min-metric operation of the parameters mode and mean of each core set is proposed. Since RSSI data is highly overlapping, so IST algorithm can not cluster properly in the overlapping region. Another type of splitting technique is introduced in the overlapping regions. For finding the pair of overlapping clusters and overlapping regions minimal spanning tree based and set theoretic based mathematical formulation have been developed in this paper. Finally, the optimal splitting technique in the overlapping region based on maximizing the between class variance is introduced. This algorithm is tested on several real life data.
Provided for Non-commercial Research and Educational Use Only. Not for Reproduction, Distribution or Commercial Use. Handbook of Cell Signaling, Three-volume Set 2 Ed. an Overview of Ion Channel Structure

This chapter was originally published in the book Handbook of Cell Signaling 2nd edition, published by Elsevier, and the attached copy is provided by Elsevier for the author's benefit and for the benefit of the author's institution, for non-commercial research and educational use including without limitation use in instruction at your institution, sending it to specific colleagues who know you, and providing a copy to your institution's administrator. All other uses, reproduction and distribution, including without limitation commercial reprints, selling or licensing copies or access, or posting on open internet sites, your personal or institution's website or repository, are prohibited. For exceptions, permission may be sought for such use through Elsevier's permissions site at:
On multidimensional coded modulations having uniform error property for generalized decoding and flat-fading channels

We consider the problem of uniform error property (UEP) for a coded modulation with constant energy multidimensional symbols, transmitted over the additive white Gaussian noise (AWGN) or fading channels and received by a broad class of decoders. This class includes coherent, partially coherent, double differential, and noncoherent decoders, decoders designed for fading channels, decoders using one or multiple-symbol observations, and many more. These decoders are described as special cases of a general decoder model. This decoder operates by maximizing an arbitrary likelihood function that its arguments are front-end correlator (matched-filter) outputs, A group code structure that guarantees UEP is developed by using the theory of geometrically uniform codes and applying it to the general decoder. These codes are defined over groups (commonly nonbinary) with isometric mapping to channel symbols. We show the code construction for the specific case of Lth-dimensional M-ary phase-shift keying (MPSK). An additional interesting property of these general uniform error codes is related to the case of noncoherent decoding. We show that when using codes of this family, if a code is noncoherently catastrophic, then it is also rotationally invariant. Then, the use of preceding of the input such that the code becomes rotationally transparent will also make it noncatastrophic.
Profile of paediatric occupational therapy practice in Australia

Background: The purpose of the present study was to describe a profile of Australian paediatric occupational therapy practice in terms of theories, assessments and interventions used with the most frequently seen client groups. Methods: An ex post facto survey design was utilised. A purpose-designed survey was mailed to 600 occupational therapists identified by OT Australia as working in paediatrics. Results: The response rate was 55% (n = 330). Respondents in the sample worked chiefly with children with developmental delays, learning disabilities, neurological impairments, and infants/toddlers. Theoretical models used by paediatric clinicians that were common to the most frequently seen client groups focused on sensory integration/multisensory approaches, occupational performance, and client-centred practice. Assessment tools most frequently used were the Test of Visual Motor Integration, Sensory Profile, Bruininks-Oseretsky Test of Motor Proficiency, Handwriting Speed Test, and Motor-Free Visual Perception Test. The most often used treatment methods across the four most frequently seen client groups were parent/caregiver education, sensory integration/stimulation techniques, and managing activities of daily living. Conclusions: Paediatric occupational therapists appeared to draw on a range of theoretical models. With the exception of the Sensory Profile, the assessment and treatment methods most frequently used are not congruent with the most commonly used theoretical models. It is critical that the assessment and treatment methods used are conceptually consistent with the theoretical models that guide practice. Occupational therapists need to examine the evidence and determine whether their clinical practice is grounded in the best contemporary theoretical models, assessments and interventions.
Capecitabine, Oxaliplatin, and Bevacizumab (BCapOx) Regimen for Metastatic Colorectal Cancer

The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc, 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast.net; or J. Aubrey Waddell, Professor, University of Tennessee College of Pharmacy; Oncology Pharmacist, Pharmacy Department, Blount Memorial Hospital, 907 E. Lamar Alexander Parkway, Maryville, TN 37804, e-mail: waddfour@charter.net. The information presented in this review is based on published data and clinical expertise and includes information not included in the product labeling. Incorporation of such published data provides a more robust assessment of the drugs and assists pharmacists in evaluation of orders for off-label use of these agents.
The influence of Mg2+ coordination on 13C and 15N chemical shifts in CKI1RD protein domain from experiment and molecular dynamics/density functional theory calculations

Sequence dependence of 13C and 15N chemical shifts in the receiver domain of CKI1 protein from Arabidopsis thaliana, CKI1RD, and its complexed form, CKI1RD•Mg2+, was studied by means of MD/DFT calculations. MD simulations of a 20–ns production run length were performed. Nine explicitly hydrated structures of increasing complexity were explored, up to a 40‐amino‐acid structure. The size of the model necessary depended on the type of nucleus, the type of amino acid and its sequence neighbors, other spatially close amino acids, and the orientation of amino acid NH groups and their surface/interior position. Using models covering a 10 and a 15 Å environment of Mg2+, a semi‐quantitative agreement has been obtained between experiment and theory for the V67−I73 sequence. The influence of Mg2+ binding was described better by the 15 Å as compared to the 10 Å model. Thirteen chemical shifts were analyzed in terms of the effect of Mg2+ insertion and geometry preparation. The effect of geometry was significant and opposite in sign to the effect of Mg2+ binding. The strongest individual effects were found for 15N of D70, S74, and V68, where the electrostatics dominated; for 13Cβ of D69 and 15N of K76, where the influences were equal, and for 13Cα of F72 and 13Cβ of K76, where the geometry adjustment dominated. A partial correlation between dominant geometry influence and torsion angle shifts upon the coordination has been observed. Proteins 2016; 84:686–699. © 2016 Wiley Periodicals, Inc.
Management of Klippel-Trenauny syndrome with multiple organ involvement

Klippel-Trenauny syndrome is a disturbance in the development of the mesodermal and ectodermal tissues occurring in utero, which is characterized by vascular nevi, varicose veins, soft tissue, and occasionally, bone hyperplasia. Our patient is a 6-year-old boy with presentation of left lower extremity over growth, abdominal mass, abdominal pain, bilateral buttock mass, rectal bleeding, and skin hemangiomatosis. The major problems of this case were involvement of the levator ani, external anal sphincter, and encasement of the sciatic nerves within the buttock mass. We concluded that the use of muscle and nerve stimulator for detection and saving sphincters and the nerves in these cases could improve the results of surgical resection.
Mechanism for verification of mismatched and homoduplex DNAs by nucleotides‐bound MutS analyzed by molecular dynamics simulations

In order to understand how MutS recognizes mismatched DNA and induces the reaction of DNA repair using ATP, the dynamics of the complexes of MutS (bound to the ADP and ATP nucleotides, or not) and DNA (with mismatched and matched base‐pairs) were investigated using molecular dynamics simulations. As for DNA, the structure of the base‐pairs of the homoduplex DNA which interacted with the DNA recognition site of MutS was intermittently disturbed, indicating that the homoduplex DNA was unstable. As for MutS, the disordered loops in the ATPase domains, which are considered to be necessary for the induction of DNA repair, were close to (away from) the nucleotide‐binding sites in the ATPase domains when the nucleotides were (not) bound to MutS. This indicates that the ATPase domains changed their structural stability upon ATP binding using the disordered loop. Conformational analysis by principal component analysis showed that the nucleotide binding changed modes which have structurally solid ATPase domains and the large bending motion of the DNA from higher to lower frequencies. In the MutS–mismatched DNA complex bound to two nucleotides, the bending motion of the DNA at low frequency modes may play a role in triggering the formation of the sliding clamp for the following DNA‐repair reaction step. Moreover, MM‐PBSA/GBSA showed that the MutS–homoduplex DNA complex bound to two nucleotides was unstable because of the unfavorable interactions between MutS and DNA. This would trigger the ATP hydrolysis or separation of MutS and DNA to continue searching for mismatch base‐pairs. Proteins 2016; 84:1287–1303. © 2016 Wiley Periodicals, Inc.
Estimating Google's search engine ranking function from a search engine optimization perspective

Purpose – The purpose of this paper is to estimate Google search engine’s ranking function from a search engine optimization (SEO) perspective. Design/methodology/approach – The paper proposed an estimation function that defines the query match score of a search result as the weighted sum of scores from a limited set of factors. The search results for a query are re-ranked according to the query match scores. The effectiveness was measured by comparing the new ranks with the original ranks of search results. Findings – The proposed method achieved the best SEO effectiveness when using the top 20 search results for a query. The empirical results reveal that PageRank (PR) is the dominant factor in Google ranking function. The title follows as the second most important, and the snippet and the URL have roughly equal importance with variations among queries. Research limitations/implications – This study considered a limited set of ranking factors. The empirical results reveal that SEO effectiveness can be as.
Structural mutation analysis of PTEN and its genotype‐phenotype correlations in endometriosis and cancer

The phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene encodes a tumor suppressor phosphatase that has recently been found to be frequently mutated in patients with endometriosis, endometrial cancer and ovarian cancer. Here, we present the first computational analysis of 13 somatic missense PTEN mutations associated with these phenotypes. We found that a majority of the mutations are associated in conserved positions within the active site and are clustered within the signature motif, which contain residues that play a crucial role in loop conformation and are essential for catalysis. In silico analyses were utilized to identify the putative effects of these mutations. In addition, coarse‐grained models of both wild‐type (WT) PTEN and mutants were constructed using elastic network models to explore the interplay of the structural and global dynamic effects that the mutations have on the relationship between genotype and phenotype. The effects of the mutations reveal that the local structure and interactions affect polarity, protein structure stability, electrostatic surface potential, and global dynamics of the protein. Our results offer new insight into the role in which PTEN missense mutations contribute to the molecular mechanism and genotypic‐phenotypic correlation of endometriosis, endometrial cancer, and ovarian cancer. Proteins 2016; 84:1625–1643. © 2016 Wiley Periodicals, Inc.
Conceptual mindsets and heuristics in credibility evaluation of e-Word of Mouth in tourism

Purpose – The purpose of this paper is to find out how credibility judgements intervene in the consumption of electronic-Word of Mouth (e-WOM) in tourism, as there is discrepancy in the literature about its influence on decision-making processes. Design/methodology/approach – A qualitative approach is explored, based on semi-structured interviews and observation through think-aloud protocol. This methodology provides fruitful insights as it focuses on the users’ browsing habits. The author interviewed a sample of professionals of tourism, cybertourists and bloggers. Findings – Results reveal that only part of e-WOM is granted credibility. Therefore, its persuasiveness depends on those limited positive judgements. Travellers use a conceptual mindset and a series of cognitive heuristics (homophily, crowd consensus, etc.) to assess credibility. Formal knowledge background and social pressures have proven to be weak. Research limitations/implications – This study is limited to a reduced sample of informants b.
Dual ETA/ETB vs. selective ETA endothelin receptor antagonism in patients with pulmonary hypertension

Since the identification of endothelin as a key mediator in the pathogenesis of several diseases, including pulmonary arterial hypertension (PAH), the pharmacologic control of the activated endothelin system with endothelin receptor antagonists (ETRA) has been a major therapeutic achievement for the treatment of patients with PAH. To date, dual ETA/ETB and selective ETA receptor antagonists have clinically been evaluated. To answer the question of whether selective or dual ETRA is preferable in patients with PAH, experimental and clinical data with relevance to the pulmonary circulation are reviewed in this article.