Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation Of Natural Frequencies Of Carbon Fiber Foot Plate Using FEA And Experimental Analysis

Footplates are mainly used by patients suffering from partial foot amputation. They assist a person suffering from lower extremities in walking by providing support for the foot and providing forward push off. Now a days foot plates are mainly available using carbon fiber material which is lightweight and has a very high strength to weight ratio. They have now become an alternative to plastic and metal orthoses . It also gives a better push off while coming back to its original position. During walking the loads acting on the footplate are dynamic in nature. During walking the footplate is subjected to repetitive loads that vary with respect to time which can cause failure of the plate and substantially reducing its useful life which is an important aspect of the product as carbon fiber is costly material. However if the natural frequency of the footplate is too far from the actual walking frequency, the problem can be considered static and stress analysis can be carried out to check the design adequacy of footplate under the loads acting in walking condition. The obtained stresses can be compared to the failure criteria of composites and the results will be compared to experimental results. In this study, the natural frequency of the footplate is calculated by modal analysis carried out in CAE software and compared with experimentally calculated results.
A MODEL FOR FREQUENCY-DEPENDENT FRICTION IN ONEDIMENSIONAL UNSTEADY FLUID FLOWS

This work presents a consistent thermo-mechanical model based on the continuum theory of mixtures to describe the unsteady friction in one-dimensional fluid flows in deformable pipings. The real fluid flow is treated as a virtual structured motion of several constituents, all of them having the same equation of state. The governing equations are derived in a systematc and coherent thermodynamic basis. The constitutive parameters of the model are easily determined from the knowlegment of the actual velocity profile, what constitutes one of its advantages when compared to other existing models. The governing equations form a system of hyperbolic partial differential equations whose numerical approximation is carried out by using the method of characteristics with specified time interval. A comparison with experimental data reveals that the predictions of the proposed exhibt an excellent agreement for laminar flows.
An Evolutionary Perspective on Control in IS Development Projects

Projects in the field of Information Systems Development (ISD) are particularly prone to failure because they are complex in many respects. To increase success of ISD projects, researchers and practitioners usually recommend the implementation of control. The traditional view on control involves two parties: a controller executing control and one or more controllees being controlled. To better understand why control effectiveness has not significantly improved over the last decades, this paper gives a chronological overview of existing literature on ISD project control. We find that so far, research has been strongly focusing on controller related aspects such as the creation of control portfolios. This, however, neglects that the effectiveness of control is highly dependent on the controllees’ perception and willingness to actively commit to implemented controls. We argue that a more holistic understanding of the controllee perspective on control is needed and discuss implications for theory and practice.
The Role of Interleukins in Epileptic Encephalopathies and Immunomodulation with Adrenocorticotropic Hormone

Epileptic encephalopathies make up a group of electroclinical syndromes that are characterized by to have an established presenting age, clinical neurological deterioration secondary to persistent epileptic activity and an irregular response to classical pharmacological treatments. Its etiology is variable, and its precipitating factors are controversial. Since the 90’s, the role of inflammation in epilepsy has been described, through to the findings like the presence of inflammatory cells and molecules in cerebrospinal fluid and surgical specimen from affected patients. Among the molecules that actively participate in this process we can find interleukins, which may be pro-inflammatory or anti-inflammatory and that may alter the permeability of the blood-brain barrier, modify the liberation of neurotransmitters and induce permanent neuroexcitation. The persistence of the neuronal excitability promotes the recurrence of seizure and refractariety to the conventional treatments. This is why we propose that the effectiveness of the immunomodulation therapies in patients with epileptic encephalopathies might be due to control the subjacent inflammatory state.
Book Review: I-Cubed and The Autoimmune Brain, A Five-Step Plan

The Autoimmune Brain1 explains I-Cubed, a shorthand for post-infectious autoimmunity that results from the multiplier effect of infection, immunity and inflammation, when protective immunity becomes the source of autoimmunity, conditioned by applicable environmental and genetic predisposing factors. In keeping with the post-infectious autoimmune nature of I-Cubed, neurologic and psychiatric symptoms evolve beyond a standard of care course of antibiotic therapy. Extensive serologic, electrophysiological and neuroradiographic diagnostic testing provides clues to areas of central, peripheral and autonomic nervous system, and systemic involvement that guide therapy. A multimodality therapeutic approach employing immune modulatory (Ig) therapy that addresses the underlying mechanisms and not just the symptoms of Cubed disorders is most effective. Representative cases of post-infectious autoimmunity associated with Lyme disease and PANDAS are presented.
A NOVEL TECHNIQUE FOR FACE IDENTIFICATION

This paper presents a correspondence measure method based on novel method which combines a permutation of Voila Jones Face detection method and Eigen face recognition (Identification) technique. In the proposed method, we come to overcome the problem of low accuracy. We propose a new system here to align the face using Voila Jones Face detection method followed by Eigen face recognition technique. Compared to other face detection methods, the proposed method is very efficient for the face detection purpose. The system is built to meet real time face recognition criteria.
The two wars against poverty: economic growth and the Great Society

Mq asT people, including most scholars, think the War on Poverty began with a formal declaration by Lyndon Johnson in 1964. In a sense this is true, for there was in fact no formal governmental decree before that time. Academic researchers have chosen to conduct their statistical analyses of poverty within this narrow time frame, producing books with titles like A Decade of Federal Antipoverty Programs (published in 1977), or Progress Against Poverty: A Review of the 1964-1974 Decade. And so persuasive has this scholarly conception of recent history been that public debate over the Reagan administration's domestic agenda has been based on the widespread assumption that only beginning in 1964 were great strides made toward the elimination, or at least the alleviation, of poverty in America.
Association of Interstitial Lung Disease With Clinical Characteristics of Chinese Patients With Systemic Lupus Erythematosus.

Objectives This study aims to evaluate the frequency and clinical and laboratory features of interstitial lung disease (ILD) in Chinese patients with systemic lupus erythematosus (SLE) and to evaluate the association of ILD with the clinical features. Patients and methods The study included 505 SLE patients (64 males, 441 females; mean age 35.3±15.3 years; range, 14 to 87 years) who were categorized into two groups as 449 patients without ILD and 56 patients with ILD based on evidence obtained from high-resolution computed tomography images. The demographic data, clinical and laboratory findings, SLE disease activity index score, and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index of all patients were also recorded and statistically analyzed. Results The ILD frequency in patients with SLE was 11.1%. Compared to the group of SLE patients without ILD, the group of SLE patients with ILD possessed the following statistical differences: elderly age, longer illness duration, lower level of anti-double-stranded deoxyribonucleic acid, and higher level of serum complement 3, increased ratios of Raynaud's phenomenon, moist rales and tachypnea. Multivariate logistic regression results suggested that elderly age (≥60 years), long illness duration (1-10 years, ≥10 years), Raynaud's phenomenon, and tachypnea were statistically associated with the occurrence of ILD in SLE patients. Conclusion Chinese SLE patients who possessed the factors that were statistically associated with ILD, namely, elderly age (≥60 years old), long illness duration (≥1 years), Raynaud's phenomenon, and tachypnea, were recommended to be monitored for the possibility of ILD.
Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway

Purpose To investigate the pathway and effects of minoxidil on trabecular outflow in cultured human trabecular meshwork (TM) cells. Methods After exposing primarily cultured TM cells to 0, 10, 50, or 100 µM minoxidil sulfate (MS), trabecular outflow was assessed by measuring TM cell monolayer permeability to carboxyfluorescein and transepithelial electrical resistance. To assess the pathway of permeability changes, caveolin-1, occludin, and claudin-5 levels were measured via western blot. Generation of reactive oxygen species (ROS) was measured using the dichlorofluorescein diacetate assay. To assess the involvement of nitric oxide (NO) in minoxidil-induced permeability increase, the degrees of endothelial nitric oxide synthase mRNA expression and NO production were measured with reverse transcription polymerase chain reaction and Griess assays, respectively. Permeability was also measured with co-exposure to 50 µM N-acetyl cysteine. Results MS significantly increased TM cell monolayer permeability (p < 0.05) and decreased transepithelial electrical resistance (p < 0.05). MS decreased the degree of endothelial nitric oxide synthase mRNA expression but did not affect NO production. MS decreased occludin and claudin-5 levels but did not affect caveolin-1 level. MS at 100 µM increased the generation of ROS, and MS-induced permeability increase was attenuated after co-exposure to 50 µM N-acetyl cysteine. Conclusions Minoxidil may preferentially increase trabecular permeability via a paracellular pathway by downregulation of tight junction proteins. This minoxidil-induced permeability through the TM may be mediated by generation of ROS.
Labor Market Frictions and Corporate Financing Decisions: Evidence from Wrongful Discharge Laws

I exploit the passage of state wrongful discharge laws as a source of exogenous variation in the rigidity of labor costs to evaluate the impact of labor market frictions on corporate financing decisions. These laws require employers to have appropriate justifications for discharging an employee and therefore limit an employer’s ability to terminate an employee at-will. These laws can lower firms’ debt capacity and induce firms to adopt more conservative financial policies by reducing profitability, increasing the riskiness of cash flows, increasing operating leverage, and increasing the likelihood of underinvestment. Consistent with firms adopting more conservative financial policies when labor costs become more rigid, I find that firms reduce financial leverage following the passage of wrongful discharge laws. This finding is more pronounced for firms with greater exposure to increases in the rigidity of labor costs. Specifically, these laws have an especially strong impact on firms that are more labor-intensive, rely less on temporary workers, and have more volatile cash flows. I also find that an increase in the rigidity of labor costs leads to financially constrained firms holding more cash and using cash holdings to cover cash flow shortfalls. Lastly, consistent with conservative financial policies being valuable for firms that face more rigid labor costs, the market value of an additional dollar of cash holdings increases following the passage of these laws. Overall, these findings suggest that labor market frictions in the form of rigid labor costs have a significant impact on firms’ financing decisions. * Department of Finance, University of Arizona, Tucson, AZ. , 85721-0108, serfling@email.arizona. edu, 218-244-7965. I am grateful for the helpful comments from Sandy Klasa, Ryan Williams, and PhD workshop participants at the University of Arizona.
The crash alarm is ringing: The predictability of earnings conference call tone for price crash risk

This paper investigates whether and how the linguistic tone of earnings conference calls predicts future stock price crash risk. Using a large sample of U.S. public firm earnings conference call transcripts from 2010 to 2015, we find strong evidence that firms face higher stock price crash risk in the coming year exhibit less optimistic tone during current year-end calls. The predictability of call tone for future crash risk is mainly driven by the manager tone and the Q&A section tone. Taken together, our results shed light on the predictive ability of corporate voluntary communication for future price crash risk.
Prolonged follow-up in diabetic retinopathy treated by sectioning the pituitary stalk.

: Because no complete long-term follow-up of visual status after pituitary ablation has been reported, records were reviewed on all 40 patients undergoing sectioning of the pituitary stalk for diabetic retinopathy at the Mayo Clinic from 1961 through 1968. One patient died and another was blind immediately postoperatively. One patient was lost to follow-up after 125 months. Twenty-seven patients have died after a follow-up interval of 7 to 120 months (mean, 63 months). The last available evaluation of these patients indicated stable or improved visual acuity in 20 patients. Eleven patients remain alive. Seven of these have stable or improved visual acuity and retinopathy. We conclude that although late post-operative mortality is high, in carefully selected patients with florid retinopathy but no fibrosis, pituitary ablation is an effective method for maintaining visual acuity.
The Wind’s Fatal Blow: the Effect of Transported Air Pollution on Mortality∗

We estimate the nationwide mortality effects of acute pollution exposure in the US over the period 1972–1988. Using wind direction as an instrument for changes in daily pollution levels, we estimate that a one-day increase in sulfur dioxide (SO2) exposure of one part per billion increases all-age mortality by 0.15 deaths per million over three days. Our estimated effects are largest for the elderly, but are also significant for infants and non-elderly adults. We also find that the marginal mortality effect of SO2 is larger in counties that are richer and less polluted. Our results suggest that a uniform reduction in pollution levels would benefit high-income individuals more than low-income individuals and lead to higher mortality reductions in areas with lower pollution levels, all else equal. JEL Classification: I18, Q52, Q53
The Web as an Adaptive Network:

Much is known about the complex network structure of the Web, and about behavioral dynamics on the Web. A number of studies address how behaviors on the Web are affected by different network topologies, whilst others address how the behavior of users on the Web alters network topology. These represent complementary directions of influence, but they are generally not combined within any one study. In network science, the study of the coupled interaction between topology and behavior, or statetopology coevolution, is known as ‘adaptive networks’, and is a rapidly developing area of research. In this paper, we review the case for considering the Web as an adaptive network and several examples of state-topology coevolution on the Web. We also review some abstract results from recent literature in adaptive networks and discuss their implications for Web Science. We conclude that adaptive networks provide a formal framework for characterizing processes acting ‘on’ and ‘of’ the Web, and offers potential for identifying general organizing principles that seem otherwise illusive in Web Science.
Critical care nursing organizations and activities: a third worldwide review

1 Foundation Chair, World Federation of Critical Care Nurses, 2 Professor of Nursing, Griffith University, Gold Coast, 3 Professor and Director, Research Centre for Clinical Practice Innovation, Griffith University, Gold Coast, 4 Executive Director of Nursing & Midwifery, Gold Coast Health Service District, 5 Research Nurse Officer, Gold Coast Hospital, Southport, 6 Professor of Nursing, Australian Catholic University, 7 Nursing Director Research & Practice Development,The Prince Charles Hospital, Brisbane, QLD, Australia, 8 Specialist on Education, Master Candidate, Universidad de San Andrés, 9 Intensive Care Unit Liaison Nurse, Sanatorio Sagrado Corazón, Buenos Aires, Argentina, 10 President of the European federation of Critical Care Nursing associations, EfCCNa, 11 Recruitment Manager, Sun Medical AS, Employment Agency, Reykjavik, Iceland, 12 Lecturer, Faculty of Health Sciences, Department of Nursing Education, University of the Witwatersrand, Witwatersrand, South Africa, 13 Senior Clinical Associate (Critical Care), School of Nursing, Hong Kong Polytechnic University, Hong Kong
NAÏVE MODELING IN A MIDDLE SCHOOL SCIENCE CLASSROOM 1 The Effect of Argument-Based Naïve Model Development upon Student Content Knowledge and Perception of Science: Middle School Science Classroom

Since the release of the 2012 Framework for K-12 Science Education, educational institutions have been tasked to increase scientific literacy through the implementation of more robust science standards. The Framework identifies three key dimensions of science education: Scientific and Engineering Practices, Crosscutting Concepts, and Disciplinary Core Ideas. The Scientific and Engineering Practices are composed of a variety of broad science-oriented skills such as engineering, mathematics, and argumentation. Research has clearly indicated the efficacy of engineering in fostering science education. However, the effectiveness of argumentation has not been fully explored, particularly in middle-level classrooms. In the spring semester of 2019, 151 7th grade science students participated in two treatment and three control science curricular units. In treatment units, students were presented a unit-specific phenomenon and provided a limited time frame to develop naïve explanatory models (those lacking scientific data). Classes then engaged in student-led argument sessions to debate and further develop their proposed initial models. Pre and post-assessment results indicated greater content knowledge growth occurred in Honors courses following treatment units while mid-low level classes showed little difference regardless of unit type. Despite generally positive student responses collected through randomly selected interviews however, overall interest in science was not significantly impacted by participation in treatment sessions. NAÏVE MODELING IN A MIDDLE SCHOOL SCIENCE CLASSROOM 2
FRAMEWORK FOR PHM IN THE SMART MANUFACTURING CONTEXT: INTEGRATION OF DIFFERENT APPROACHES

: The technology has advanced at an exponentially high rate since the advent of Internet in the early 90s. The concepts like e-Maintenance, Internet of Things, Industry 4.0 are linked to this advancement in technology. All these have stimulated great potentials in industries and manufacturing. This will boost Prognostics and Health Management capabilities that will need to rely not only on consolidated algorithms and IT architectures, but also on new paradigms related with distributed computing, modularization of tools and development of new services. The paper will address such approach proposing a reference framework to highlight how predictive maintenance can be interpreted according to the new paradigm of Smart Manufacturing. The framework will be supported by an industrial case.
Grey matter network measures are associated with cognitive decline in mild cognitive impairment

Grey matter networks are disrupted in Alzheimer’s disease and related to cognitive impairment. However, it is still unclear whether these disruptions are associated with cognitive decline over time. Here, we studied this question in a large sample of patients with mild cognitive impairment with extensive longitudinal neuropsychological assessments. Grey matter networks were extracted from baseline structural MRI and we tested associations of network measures and cognitive decline in MMSE and five cognitive domains (i.e., memory, attention, executive function, visuospatial and language). Disrupted network properties were cross-sectionally related to worse cognitive impairment. Longitudinally, lower small-world coefficient values were associated with a steeper decline in almost all domains. Lower betweenness centrality values correlated with a faster decline in MMSE and memory and, at a regional level, these associations were specific for the precuneus, medial frontal and temporal cortex. Furthermore, network measures showed additive value over established biomarkers in predicting cognitive decline. Our results suggest that grey matter network measures might have use in identifying patients who will show fast disease progression.
Do Vocal and Instrumental Primes Affect Word Processing Differently? An fMRI Study on the Influence of Melodic Primes on Word Processing in Chinese Musicians and Non-musicians

In various societies, especially in tone language areas, speech surrogates serve a variety of purposes including long-distance communication, conveyance of message between close encounters, etc. How speech surrogates work is not yet well understood, but there are suggestions that tonal information may assist tone-language speakers to access their mental lexicons. This study investigates whether brain activity in Chinese musicians and non-musicians during a covert word repetition task is differently affected by vocal and instrumental pitch contour primes. The analysis demonstrates that differences in effects of vocal and instrumental primes in musicians and non-musicians largely correspond to differential activation changes in the right superior temporal gyrus. The largest differences are found in the Heschl’s gyri. Musicians showed greater % BOLD changes in left than in right hemisphere while nonmusicians did not show a significant hemispheric difference. Musicians showed the highest activation changes for instrumental primes in both hemispheres whereas non-musicians showed the largest % BOLD changes for vocal primes.