Miracle-dz/UniFAR-FTUs huggingface dataset:
Personality Types And Software Engineers

(I) and extroverted (E), intuitive (N) and sensing (S), thinking (T) and feeling (F), judging (J) and perceiving (P). The results of an MBTI test yield 16 combinations of these characteristics, from ISTJ to ENFP, that describe an individual's thinking style and temperament. David Keirsey and Marilyn Bates further classify individuals as combinations of NF, NT, SP, and SJ, based on psychoanalyst Carl Jung's work on personality types. Each classification indicates how a person sees the world. Each person perceives and solves problems based on temperament. MBTI co-designer Isabel Briggs-Myers suggested that people tend to make career choices based on their temperament. For example , an ISTJ is structured and rule-based, and thus might become an accountant, a high school principal, or a banker. An ENFP is relationship-oriented and likes to help people, and thus might become a psychologist. I have observed my colleagues who are programmers to get some idea as to what types of temperaments they have. I saw that there are no NF types among my col-W hen I started in the IS industry in 1969, companies hired recent college graduates of above-average intelligence with degrees in any major as computer programmer trainees. They were given an aptitude test, which was used to predict which candidates would make good programmers and thus should receive training. I don't recall that either the test or raw intelligence accurately predicted who would become a good programmer. I believe other predictors would be better. About 15 years ago, I stumbled across the Myers Briggs Type Indicator (MBTI), a popular psycho-metric instrument frequently used in workplace diversity and sensitivity classes given by many US human resources departments. The MBTI may be the best predictor of who will become a competent programmer. MBTI The MBTI is a quickly administered test that classifies the candidate on a continuum between introverted leagues who have been software engineers for more than five years. It appears that these types tend to have trouble with the sequential and process-oriented thinking required to design and implement software. I also observed that most really good software engineers were ENTJ, INTJ, ESTJ, ISTJ, ISFJ, and ENTP. In other words, they fall into Keirsey's and Bates' NT and SJ classifications. It appears this is the case because NT types tend to visualize the completed solution to a problem, while SJ types tend to visualize the steps necessary to implement the solution. Admittedly, …
Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

During mitosis, the recruitment of spindle-checkpoint-associated proteins to the kinetochore occurs in a defined order. The protein kinase Bub1 localizes to the kinetochore very early during mitosis, followed by Cenp-F, BubR1, Cenp-E and finally Mad2. Using RNA interference, we have investigated whether this order of binding reflects a level of dependency in human somatic cells. Specifically, we show that Bub1 plays a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of Cenp-F, BubR1, Cenp-E and Mad2. In contrast to studies in Xenopus, we also show that BubR1 is not required for kinetochore localization of Bub1. Repression of Bub1 increases the number of cells with lagging chromosomes at metaphase, suggesting that Bub1 plays a role in chromosome congression. However, repression of Bub1 does not appear to compromise spindle checkpoint function either during normal mitosis or in response to spindle damage. This raises the possibility that, in the absence of Bub1, other mechanisms contribute to spindle checkpoint function.
Submicron Imaging of Soft‐Tissues Using Low‐Dose Phase‐Contrast X‐Ray Synchrotron Microtomography With an Iodine Contrast Agent

3-D visualization of forming organs and tissues in early embryos helps understanding their developmental dynamics. 3-D reconstruction of an organ from an image stack requires: (1) a sufficient number of slices in order to obtain smooth contours, and (2) a satisfactory contrast that allows differentiating between tissue layers during segmentation. Based on these principles, satisfactory but very time-consuming techniques are available for manual segmentation and step-by-step 3-D reconstructions of small embryonic structures using histology (Viriot et al., 1997, 2000). Usual micro-CT devices available in developmental biology units do not provide the sufficient resolution required to visualize the smaller developing structures at early embryonic stages, such as tooth germs at E11.5. Furthermore, the contrast obtained from soft-tissues is low if high doses of radiation—not supported by small samples—are not used. A recent study (Raj et al., 2014) has shown that synchrotron imaging with a sliver-based contrast agent provides images of embryonic soft-tissues with a resolution of 4–10 lm. Here we show that the combination of propagation phase contrast, rapid imaging, phase retrieval and iodine contrast agent allows soft-tissue imaging with a voxel size of 0.695 lm and a relatively low radiation dose. This method provides submicronic images where single cells can be individualized.
Rediscovery of the holotype of the extinct cephalopod Baculites ovatus Say, 1820 after nearly two centuries

ABSTRACT. Thomas Say (1787–1834) based his description of the ammonite species Baculites ovata (= B. ovatus) on a single specimen in the collection of his childhood friend, the Quaker naturalist Reuben Haines III (1786–1831). However, the specimen's whereabouts faded from memory after Haines and Say both died unexpectedly in the early 1830s. The holotype specimen has been missing for more than 180 years, and was thought to be lost or destroyed until 2017, when I relocated it at Haines's ancestral home (Wyck) in Philadelphia, Pennsylvania, where his collection was preserved by his descendants in its original wooden cabinet. Herein, I present the first photographic images, an illustration of its suture line, and quantitative measurements for use by systematic paleontologists.
533 EFFECT OF INTRALIPID ON OXLDATIVE METABOLIC & FUNCTIONAL ACTIVITIES OF POLYMORPHONUCLEAR LEUKOCYTES (PMNL)

Intralipid (I) is a soy bean emulsion commonly used in parenteral alimentation. We evaluated the oxidative metabolic and functional activities of PMNL exposed to various conc. of this substance. Intralipid produced a dose dependent stimulation of resting PMNL as measured by hexose monophosphate (HMPS) activity, nitroblue tetrazolium dye reduction (NBT), and oxygen consumption (O2):There was no difference between control PMNL stimulated with zymosan (Z) and cells stimulated with Z plus I. When PMNL were preincubated with I for 30 min. at conc. of 100 mg/ml or greater, Z stimulated HMPS activity (2199 ± 502) and NBT dye reduction (0.04±.005) were reduced (P <0.01) when compared to non preincub. PMNL stimulated with Z: HMPS 7402 ± 752 and NBT 0.61±0.06. No effect was noted after preincubation with smaller conc. of I. Analysis of the kinetics of phagocytosis using 3H methyl thymidine labeled S. aureus show that preincubation of PMNL with I (100 mg/ml) caused a significant decrease in internalization of bacteria. Low conc. of I cause immediate stimulation of PMNL oxidative metabolism while higher conc. produce a significant inhibition in activity. This may be important in administration of I.
The Women's Antioxidant Cardiovascular Study: design and baseline characteristics of participants.

BACKGROUND The evidence for a potential benefit of antioxidant vitamins and folic acid in cardiovascular disease (CVD) prevention is derived from laboratory, clinical, and observational epidemiological studies but remains inconclusive. Large-scale randomized trials with clinical end points are necessary to minimize confounding and provide unbiased estimates of the balance of benefits and risks, yet data from such trials are scarce, especially among women. METHODS The Women's Antioxidant Cardiovascular Study (WACS) is a randomized, double-blind, placebo-controlled trial testing whether antioxidant vitamins and a folic acid/vitamin B(6)/vitamin B(12) combination prevent future cardiovascular events among women with preexisting CVD or >or=3 CVD risk factors. This paper describes the design of the trial and baseline characteristics of participants, evaluates the success of randomization, and addresses the generalizability of future findings. RESULTS In a factorial design, 8171 U.S. female health professionals aged >or=40 years were randomized to vitamin E, vitamin C, beta-carotene, or placebos. Of these women, 5442 were also subsequently randomized to folic acid/vitamin B(6)/vitamin B(12) or placebo. The randomization was successful, as evidenced by similar distributions of baseline demographic, health, and behavioral characteristics across treatment groups. The clinical profile of participants was similar to that observed in another large trial of women with CVD. CONCLUSIONS The similar distribution of known potential confounders across treatment groups provides reassurance that unmeasured or unknown potential confounders are also equally distributed. Although a definitive conclusion regarding generalizability requires additional trials in diverse populations, there is little biological basis for supposing that the benefit-risk balance differs in other high-risk women.
Movement and Color Detection of a Dynamic Object: An application to a Mobile Robot

The paper describes the integration of several image processing algorithms necessary to recognize a particular color and the movement of an object. The main objective is to detect the object by its color and track it by a mobile robot. Mean filter is applied to soften and sharpen the input image. Then, RGB filter is applied to calculate the center of mass and area of the object and to locate its position in a real environment to develop the robot motion. These algorithms are applied to a mobile robot, in a tested scenario, tracking an object.
ATRVJr – mobile robot for Fire Fighter Services

Following paper shows the result of the development mobile robot ATRVJr for Fire Fighter Services dedicated to the risky intervention tasks. The concept of the hybrid software architecture based on Player and CORBA is shown. The basic functionalities such as SLAM, autonomous navigation and 3D map building are described. The HMI equipped with 3D visualization module is demonstrated. The experiment of ATRVJr assistance during Fire Fighters demo action is described.
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment

MicroRNAs (miRNAs) are short non-protein-coding RNAs that post-transcriptionally regulate mRNA expression. A large body of evidence has identified important roles for these regulators in cell proliferation, differentiation, apoptosis and metabolism, as well as activation of oncogenic and antioncogenic signals. Aberrant expression of miRNAs has been found in most human malignancies and is strongly associated with tumorigenesis, prediction, diagnosis, progress, treatment and prognosis. Thus, miRNAs may become an intriguing and promising therapeutic target for many diseases, including cancer. In addition, research into miRNAs may provide insight into the mechanisms underlying tumor occurrence, progression and metastasis. This review summarizes the current knowledge of miRNAs, their roles in lung cancer and avenues for future research.
Health Needs of Young Offenders

Health services’ input to the Youth Offending Teams (YOTs) is an integral component of the YOTs’ philosophy. Fifty young people aged 14–18 years, who attended two representative YOTs consecutively, completed a health checklist and a strengths and difficulties questionnaire. They were interviewed on the health of the nation outcome scales for children and adolescents and their perceptions of health needs and services. The young people reported high rates of accidents and injuries, admissions to hospital, emotional and peer relationships difficulties. Their perceptions of what mental illness means varied between stigma, aggression, lack of coping, previous experiences and physical ill-health. Only five young people expressed a wish to receive mental health help. The findings are discussed in relation to health services provision to the YOTs.
Assessing the Association of Pioglitazone Use and Bladder Cancer Through Drug Adverse Event Reporting

OBJECTIVE To analyze the association between pioglitazone use and bladder cancer through a spontaneous adverse event reporting system for medications. RESEARCH DESIGN AND METHODS Case/noncase bladder cancer reports associated with antidiabetic drug use were retrieved from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) between 2004 and 2009 and analyzed by the reporting odds ratio (ROR). RESULTS Ninety-three reports of bladder cancer were retrieved, corresponding to 138 drug-reaction pairs (pioglitazone, 31; insulin, 29; metformin, 25; glimepiride, 13; exenatide, 8; others, 22). ROR was indicative of a definite risk for pioglitazone (4.30 [95% CI 2.82–6.52]), and a much weaker risk for gliclazide and acarbose, with very few cases being treated with these two drugs (6 and 4, respectively). CONCLUSIONS In agreement with preclinical and clinical studies, AERS analysis is consistent with an association between pioglitazone and bladder cancer. This issue needs constant epidemiologic surveillance and urgent definition by more specific studies.
Antioxidant capacity, total phenolics and sugar content of selected Thai health beverages

This study was to determine antioxidant capacity, total phenolics and sugar content of 12 pasteurized and sterilized Thai health beverages, products of The Royal Chitralada Projects. The antioxidant capacities were analyzed using 2,2-diphenyl-1-picrylhydrazyl radical scavenging and the photochemiluminescence (PCL) assay. Folin-Ciocalteu assay and Nelson's reducing sugar test were used to determine total phenolic compounds and sugar contents, respectively. Sacred lotus root drink showed the significantly highest antioxidant capacity in both equivalents to trolox and equivalents to ascorbic acid but not in the PCL test. In contrast, chrysanthemum drink and roselle drink showed the significantly highest values of both the total antioxidant capacity of water and lipid-soluble substances in the PCL assay. Bael fruit drink had the significantly highest total phenolic compounds. There were significant correlations between the total phenolic compounds and the antioxidant capacity values of both assays (r=0.4–0.5).
HIV-protease inhibitors alter retinoic acid synthesis

BackgroundAn increasing rate of highly-active antiretroviral therapy (HAART)-associated metabolic and morphological abnormalities has been reported in HIV-infected persons. Some of them resemble retinoid-related adverse events, indicating alteration(s) of retinol metabolism or of retinoic acid-mediated signalling. ObjectiveTo evaluate retinol levels in patients with or without HAART and to assess the effect of antiretroviral agents on retinal dehydrogenase (RALDH), a key enzyme involved in retinoic acid synthesis. DesignPlasma retinol levels, measured in six patients receiving HAART and in five others with no antiretroviral therapy, were correlated with levels of serum retinol-binding proteins. We then studied the effects of seven antiretroviral agents on RALDH activity and gene expression in a kidney-derived cell line (LLCPK). ResultsPlasma retinol levels in patients receiving HAART were decreased in comparison with those not receiving antiretroviral drugs (51 ± 5 versus 66 ± 11 μg/dl;P = 0.03), whereas retinol-binding protein levels were increased (68 ± 18 versus 45 ± 10 mg/l;P = 0.04). RALDH activity was heightened by ritonavir (24%), indinavir (17%), saquinavir (17%), zalcitabine (14%), delavirdine (12%) and nelfinavir (10%) and decreased (22%) by DMP-450. RALDH gene expression was induced only by indinavir. ConclusionsThese data indicate that certain retinoid-like adverse effects in HAART-receiving patients are not due to higher retinol levels. Enhanced RALDH activity or/and gene expression by some protease inhibitors could increase retinoic acid concentrations. Elevated retinoic acid levels might be responsible for retinoid-like or other adverse effects due to alterations in the expression of retinoic acid-responsive genes.
Metabolic constraints and quantitative design principles in gene expression during adaption of yeast to heat shock

Microorganisms evolved adaptive responses that enable them to survive stressful challenges in ever changing environments by adjusting metabolism through the modulation of gene expression, protein levels and activity, and flow of metabolites. More frequent challenges allow natural selection ampler opportunities to select from a larger number of phenotypes that are compatible with survival. Understanding the causal relationships between physiological and metabolic requirements that are needed for cellular stress adaptation and gene expression changes that are used by organisms to achieve those requirements may have a significant impact in our ability to interpret and/or guide evolution. Here, we study those causal relationships during heat shock adaptation in the yeast Saccharomyces cerevisiae. We do so by combining dozens of independent experiments measuring whole genome gene expression changes during stress response with a nonlinear simplified kinetic model of central metabolism. This combination is used to create a quantitative, multidimensional, genotype-to-phenotype mapping of the metabolic and physiological requirements that enable cell survival to the feasible changes in gene expression that modulate metabolism to achieve those requirements. Our results clearly show that the feasible changes in gene expression that enable survival to heat shock are specific for this stress. In addition, they suggest that genetic programs for adaptive responses to desiccation/rehydration and to pH shifts might be selected by physiological requirements that are qualitatively similar, but quantitatively different to those for heat shock adaptation. In contrast, adaptive responses to other types of stress do not appear to be constrained by the same qualitative physiological requirements. Our model also explains at the mechanistic level how evolution might find different sets of changes in gene expression that lead to metabolic adaptations that are equivalent in meeting physiological requirements for survival. Finally, our results also suggest that physiological requirements for heat shock adaptation might be similar between unicellular ascomycetes that live in similar environments. Our analysis is likely to be scalable to other adaptive response and might inform efforts in developing biotechnological applications to manipulate cells for medical, biotechnological, or synthetic biology purposes.
Autonomous behavioral strategy and optimal centralized guidance for on-orbit self assembly

Swarms of satellites, intended as a large number of spacecraft performing a common mission, appear to be particularly apt for an application of the so-called behavioral control strategies in the astrodynamics. The basic concept of the behavioral strategies lies in the imitation of natural swarms of social animals, like flocks of birds, which are characterized by a global group organization acquired in absence of a centralized control. In particular, an on-orbit self assembly manoeuvre is analyzed. Since every satellite takes its own decisions being able to consider only a small number of neighbor satellites and limited intercommunication, full autonomy is achieved. However optimality in terms of control cost and required time for complete self assembly is an issue which is not even taken in consideration. In this work, the behavioral results are compared with a typical centralized control, with an active leader which is able to detect the position and the dynamics of each swarm member and to compute the optimal guidance towards the fittest slot around the leader. In such a way, the optimality of the swarm manoeuvre is reached, at the cost of a great complication in the system architecture of the leader. Special attention will be dedicated to the filtering strategies, in particular to particle filters, apt to solve navigation problems including a large number of close members, when measurements ambiguity can occur. An extensive simulation campaign, for various orbit configurations and swarm dimensions, is performed in order to clearly assess and quantify the advantages and drawbacks of the behavioral and centralized strategies.
Monitoring the fetal heart non-invasively: a review of methods

Abstract Doppler ultrasound, ultrasound M-mode analysis, fetal electrocardiography, and fetal magnetocardiography are methods by which the fetal heart can be monitored non-invasively. In this paper, they are evaluated and compared. Customarily, it is solely the fetal heart rate, which is monitored using the Doppler ultrasound technique since it is both simple to use and cheap. However, this method inherently produces an averaged heart rate and therefore cannot give the beat-to-beat variability. Fetal electrocardiography has similar advantages, but in addition offers the potential for monitoring beat-to-beat variability and performing electrocardiogram morphological analysis. Its disadvantage is that its reliability is only 60 %, although it is the only technique that offers truly long-term ambulatory monitoring. Ultrasound M-mode analysis allows a estimation of atrial and ventricular coordination, as well as an estimation of PR intervals. Bradycardias, supraventricular tachycardias, extra systoles are readily diagnosed using this method although timing will be inaccurate. Fetal magnetocardiograms can be detected reliably and used for accurate beat-to-beat measurements and morphological analysis. Consequently, they can be used for the classification of arrhythmias and the diagnosis of a long QT syndrome and some congenital heart diseases.
Changes in qnr Prevalence and Fluoroquinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Enterobacter spp. Collected from 1990 to 2005

ABSTRACT Clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 through 2005 at a tertiary care center were studied for qnr genes. Isolates bearing these genes emerged in the mid-1990s, coinciding with the time of a rapid increase in fluoroquinolone resistance. Sixty percent of these isolates were ciprofloxacin susceptible by CLSI breakpoints.
The role of matrix stiffness in regulating cell behavior

Matrix stiffness (resistance to deformation), one of the many mechanical forces acting on cells, is increasingly appreciated as an important mediator of cell behavior. It regulates cell signaling broadly, with effects on growth, survival, and motility. Although the stiffness optima for different kinds of adherent cells vary widely, it is generally true that cell proliferation and differentiation increase with the stiffness of the matrix. This review summarizes recent data exploring the nature of matrix stiffness, mechanotransducers, and the many effects of changes in stiffness on cell function. Particular mention is made of data suggesting that cells of the liver are mechanosensitive, highlighting the potential importance of these findings in understanding the biology of normal and diseased liver. (HEPATOLOGY 2008.)