Miracle-dz/UniFAR-FTUs huggingface dataset:
[Deletion of p15 and p16 genes and overexpression of STK15 gene in human laryngeal squamous cell carcinoma].

OBJECTIVE To investigate the association of p15 and p16 genes deletion, and STK15 gene overexpression with laryngeal squamous cell carcinoma (LSCC). METHODS The cancer tissue and surrounding normal tissue were taken during operation from 50 cases of LSCC who had undergone neither chemotherapy nor radiotherapy preoperatively. DNA was extracted and PCR was used to test the homozygous deletion of p15 exon 2 (p15E2) and p16 exon 2 (p16E2). RNA was extracted, cDNA was synthesized by reverse transcription, and the expression of STK15 gene was tested by PCR with beta-actin as inner control. At the same time the expression of STK15 in human LSCC Hep-2 cell line was tested. The ratio of ADV (average density value) of STK15 gene to the ADV of beta-actin gene was calculated. RESULTS The rate of p15E2 deletion was 12% (6/50) and that of p16E2 was 14% (7/50). The p15E2 and p16E2 codeletion rate was 6% (3/50). In 34 of the 50 cases (68%) the expression of STK15 gene in tumor tissue was higher than that of the paired surrounding normal tissue with a significant difference. The ratio of ADV of STK15 gene to ADV of beta-actin gene was 1.03 +/- 0.30 in the cancer tissue, and 0.89 +/- 0.22 in the paired normal tissue with a significant difference (t = 4.333, P < 0.01). The expression of STK15 gene was higher than that of beta-actin in Hep-2 cell line. CONCLUSION The homozygous deletion of p15E2 and p16E2 and overexpression of STK15 gene may play a role in the oncogenesis and malignant progression of laryngeal squamous cell carcinoma.
Optimisation of solar energy collection with smart adaptive control

Solar power plants collect available thermal energy in a usable form at the desired temperature range. Efficient operation requires a fast start-up and reliable operation in varying cloudy conditions without unnecessary shutdowns and start-ups. Fast and well damped linguistic equation (LE) controllers have been tested in Spain at a collector field, which uses parabolic-trough collectors to supply thermal energy in form of hot oil to an electricity generation system or a multi-effect desalination plant. Control is achieved by means of varying the flow pumped through the pipes in the field during the operation. Solar energy can be collected only when the irradiation is high enough. The nights and the heavy cloud periods need to come up with the storage. The LE controllers extend the operation to varying cloudy conditions in a smart way. Varying energy demand during the daytime can be smoothly handled in the LE control system with predefined model-based adaptation techniques. The system activates special features when needed. The intelligent state indicators react well to the changing operating conditions and can be used in smart working point control to further improve the operation in connection with the other energy sources in SmartGrids. The working point can be chosen in a way which improves the efficiency of the energy collection. A trade-off of the temperature and the flow is needed to achieve a good level for the collected power.
Group sparse reconstruction using intensity‐based clustering

Compressed sensing has been of great interest to speed up the acquisition of MR images. The k‐t group sparse (k‐t GS) method has recently been introduced for dynamic MR images to exploit not just the sparsity, as in compressed sensing, but also the spatial group structure in the sparse representation. k‐t GS achieves higher acceleration factors compared to the conventional compressed sensing method. However, it assumes a spatial structure in the sparse representation and it requires a time consuming hard‐thresholding reconstruction scheme. In this work, we propose to modify k‐t GS by incorporating prior information about the sorted intensity of the signal in the sparse representation, for a more general and robust group assignment. This approach is referred to as group sparse reconstruction using intensity‐based clustering. The feasibility of the proposed method is demonstrated for static 3D hyperpolarized lung images and applications with both dynamic and intensity changes, such as 2D cine and perfusion cardiac MRI, with retrospective undersampling. For all reported acceleration factors the proposed method outperforms the original compressed sensing method. Improved reconstruction over k‐t GS method is demonstrated when k‐t GS assumptions are not satisfied. The proposed method was also applied to cardiac cine images with a prospective sevenfold acceleration, outperforming the standard compressed sensing reconstruction. Magn Reson Med 69:1169–1179, 2013. © 2012 Wiley Periodicals, Inc.
Framing Biotechnology: A Comparison of U.S. and British National Newspapers

Despite the potential promise of agricultural biotechnology, consumers’ trust and acceptance varies in some parts of the world. To develop a deeper understanding of the differences in news media coverage of agricultural biotechnology in U.S. and British newspapers, a framing analysis study was conducted, focusing on the news coverage of three major national “newspapers of record” during the calendar year 2002: The New York Times, The Washington Post, and The Guardian. No single frame was dominant in U.S. or British national newspaper coverage of agricultural biotechnology in 2002. Some of the prominent frames were contamination of the food supply, human risk, environmental risk, scientific progress, and world hunger. There were more different frames used in The Guardian (concepts as consumer choice, dependency, and politics) than in the U.S. newspapers. Additionally, this study reiterated findings that British news coverage included more editorial coverage of agricultural biotechnology. This research is available in Journal of Applied Communications: https://newprairiepress.org/jac/vol88/iss2/2
VON HIPPEL–LINDAU TUMOUR SUPPRESSOR GENE. LOCALIZATION OF EXPRESSION BY IN SITU HYBRIDIZATION

Inactivation of the von Hippel–Lindau (VHL) tumour suppressor gene is responsible not only for VHL disease, but also for sporadic renal cell carcinoma and cerebellar haemangioblastoma. The distribution of VHL gene expression in the mouse embryo was recently studied by in situ hybridization, along with human VHL in 14‐week‐old fetal kidney: there was widely distributed expression in the former and expression in the tubules and blastema in the latter. Adult human tissue and other fetal organs were not examined. The present paper describes an in situ hybridization study to assess the function of the VHL gene in adult human tissues and in tissues of human fetus at 28 weeks of gestation. The expression of the VHL gene was limited to the adult and fetal brain and kidney, and the adult prostate. Nerve cells in adult and fetal brain were positive, including the cerebellar Purkinje cells. In adult and fetal kidney, the proximal tubular epithelium, the putative origin of the common type of renal cell carcinoma, showed intense signal, whereas the distal nephron, glomeruli, and nephrogenic blastema showed no significant signal. The prostate showed significant signal in the basal epithelium. The adrenal, pancreas, and epidydimis showed no significant signal, in spite of the frequent occurrence at these sites of neoplastic or hamartomatous lesions in VHL disease.
A modulated excitation imaging system for microultrasound

Micro-ultrasound (micro-US), also known as ultrasound biomicroscope, is able to delineate small structures with fine spatial resolution. However, micro-US suffers limited depth of penetration due to significantly large attenuation at high frequencies. Modulated excitation imaging has displayed the capability to improve the penetration depth, while maintaining the spatial resolution. But the effectiveness of this technique in micro-US has not been fully demonstrated. This paper presents the development of a novel system to achieve modulated excitation imaging with high programmability and flexibility to satisfy various micro-US studies. Test results show that the proposed modulated excitation imaging system can acquire up to 20 dB signal-to-noise ratio improvement and 83% increase of penetration depth in contrast to traditional short-pulse imaging method. In vivo experiment on the dorsal skin of a human hand demonstrates good performance of the programmable modulated excitation imaging system.
Place-Type Detection in Location-Based Social Networks

Determining the type of places in location-based social networks will contribute to the success of various downstream tasks such as POI recommendation, location search, automatic place name database creation, and data cleaning. In this paper, we propose a multi-objective ensemble learning framework that (i) allows the accurate tagging of places into one of the three categories: public, private, or virtual, and (ii) identifying a set of solutions thus offering a wide range of possible applications. Based on the check-in records, we compute two types of place features from (i) specific patterns of individual places and (ii) latent relatedness among similar places. The features extracted from specific patterns (SP) are derived from all check-ins at a specific place. The features from latent relatedness (LR) are computed by building a graph of related places where similar types of places are connected by virtual edges. We conduct an experimental study based on a dataset of over 2.7M check-in records collected by crawling Foursquare-tagged tweets from Twitter. Experimental results demonstrate the effectiveness of our approach to this new problem and show the strength of taking various methods into account in feature extraction. Moreover, we demonstrate how place type tagging can be beneficial for place name recommendation services.
Ten-year follow-up study of premenopausal women with metastatic breast cancer: an Eastern Cooperative Oncology Group study.

PURPOSE To investigate the long-term survival of premenopausal women with previously untreated first recurrence or metastases of breast cancer entered on Eastern Cooperative Oncology Group (ECOG) study 2177 (EST 2177), which completed accrual in June 1983. MATERIALS AND METHODS One hundred forty-seven premenopausal women with metastatic breast cancer were entered onto the study. Eighty-nine patients with estrogen receptor (ER)-positive and ER-unknown disease were randomized to receive cyclophosphamide (CTX), doxorubicin (ADR), and fluorouracil (FU) (CAF) or surgical oophorectomy plus CAF (O+CAF). Fifty-eight patients with known ER-negative disease were treated with CAF. Survival time was measured from the time of study entry. Randomization was stratified by performance status (PS), dominant metastatic site, and ER status. RESULTS One hundred thirty patients were eligible. The median survival time of randomized patients was 35 months (90% confidence interval, 28.9 to 54.3), with 28% alive at 5 years. The overall median survival duration, including ER-negative patients, was 30 months. There was no significant difference in survival time between the randomized treatments (median, 42 months for O+CAF and 30 months for CAF). In models of survival time, age > or = 45 years and last menstruation within 1 month were associated with significantly longer survival (P < .004 for each). There were also three significant interactions with treatment (even after correction for multiple comparisons): age (P = .00009; O+CAF associated with longer survival in patients < 45 years, CAF associated with longer survival in patients > 45 years), PS (P = .002; O+CAF associated with consistently better survival in PS O patients), and disease-free interval (DFI). CONCLUSION Long-term follow-up data of premenopausal women with metastatic breast cancer show a longer than expected median survival time at 2.5 years overall and close to 5 years for patients treated with O+CAF who were ER-positive or had a good PS.
Análisis comparativo del cambio organizacional e institucional de dos incubadoras de empresas

The objective of this article is to compare organizational and institutional change in two business incubators, one in Medellin, Colombia and another one in Barcelona, Spain; The influence of internal and external factors are both considered as well as the existence, incorporation and institutionalization of public policies as well as business and entrepreneurial programs. A qualitative case study strategy was used for developing the methodological aspect, which supported the documental analysis for the semistructuredinterview. The main results show that the Colombian incubator changed its business name because of financial self sustainability needs and lack of coordination and articulation from the NationalScience, Technology and Innovation System, while the incubator from Spain consolidated its business name broadening its organizational capacities thanks to the favorable opportunities offered by National Science, Technology and Innovation system.
Role of Neuropathy and High Foot Pressures in Diabetic Foot Ulceration

OBJECTIVE High plantar foot pressures in association with peripheral neuropathy have been ascertained to be important risk factors for ulceration in the diabetic foot. Most studies investigating these parameters have been limited by their size and the homogeneity of study subjects. The objective of this study was therefore to ascertain the risk of ulceration associated with high foot pressures and peripheral neuropathy in a large and diverse diabetic population. RESEARCH DESIGN AND METHODS We studied a cross-sectional group of 251 diabetic patients of Caucasian (group C) (n = 121), black (group B) (n = 36), and Hispanic (group H) (n = 94) racial origins with an overall age of 58.5 ± 12.5 years (range 20–83). There was an equal distribution of men and women across the entire study population. All patients underwent a complete medical history and lower extremity evaluation for neuropathy and foot pressures. Neuropathic parameters were dichotomized (0/1) into two high-risk variables: patients with a vibration perception threshold (VPT) ≥25 V were categorized as HiVPT (n = 132) and those with Semmes-Weinstein monofilament tests ≥5.07 were classified as HiSWF (n = 190). The mean dynamic foot pressures of three footsteps were measured using the F-scan mat system with patients walking without shoes. Maximum plantar pressures were dichotomized into a high-pressure variable (Pmax6) indicating those subjects with pressures ≥6 kg/cm2 (n = 96). A total of 99 patients had a current or prior history of ulceration at baseline. RESULTS Joint mobility was significantly greater in the Hispanic cohort compared with the other groups at the first metatarsal-phalangeal joint (C 67 ± 23°, B 69 ± 23°, H 82 ± 23°, P = 0.000), while the subtalar joint mobility was reduced in the Caucasian group (C 21 ± 8°, B 26 ± 7°, H 27 ± 11°, P = 0.000). Maximum plantar foot pressures were significantly higher in the Caucasian group (C 6.7 ± 2.9 kg/cm2, B 5.7 ± 2.8 kg/cm2, H 4.4 ±1.9 kg/cm2 P = 0.000). Univariate logistic regression for Pmax6 on the history of ulceration yielded an odds ratio (OR) of 3.9 (P = 0.000). For HiVPT, the OR was 11.7 (P = 0.000), and for HiSWF, the OR was 9.6 (P = 0.000). Controlling for age, diabetes duration, sex, and race (all P < 0.05), multivariate logistic regression yielded the following significant associations with ulceration: Pmax6 (OR = 2.1, P = 0.002), HiVPT (OR = 4.4, P = 0.000), and HiSWF (OR = 4.1, P = 0.000). CONCLUSIONS We conclude that both high foot pressures (≥6 kg/cm2) and neuropathy are independently associated with ulceration in a diverse diabetic population, with the latter having the greater magnitude of effect. In black and Hispanic diabetic patients especially, joint mobility and plantar pressures are less predictive of ulceration than in Caucasians.
Surfactant‐Directed Synthesis of Branched Bismuth Telluride/Sulfide Core/Shell Nanorods

Branched core/shell bismuth telluride/bismuth sulfide nanorod heterostructures are prepared by using a biomimetic surfactant, L-glutathionic acid. Trigonal nanocrystals of bismuth telluride are encapsulated by nanoscopic shells of orthorhombic bismuth sulfide. Crystallographic twinning causes shell branching. Such heteronanostructures are attractive for thermoelectric power generation and cooling applications.
A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence.

BACKGROUND Opioid dependence is a chronic, relapsing disorder with important public health implications. METHODS In a 17-week randomized study of 220 patients, we compared levomethadyl acetate (75 to 115 mg), buprenorphine (16 to 32 mg), and high-dose (60 to 100 mg) and low-dose (20 mg) methadone as treatments for opioid dependence. Levomethadyl acetate and buprenorphine were administered three times a week. Methadone was administered daily. Doses were individualized except in the group assigned to low-dose methadone. Patients with poor responses to treatment were switched to methadone. RESULTS There were 55 patients in each group; 51 percent completed the trial. The mean (+/-SE) number of days that a patient remained in the study was significantly higher for those receiving levomethadyl acetate (89+/-6), buprenorphine (96+/-4), and high-dose methadone (105+/-4) than for those receiving low-dose methadone (70+/-4, P<0.001). Continued participation was also significantly more frequent among patients receiving high-dose methadone than among those receiving levomethadyl acetate (P=0.02). The percentage of patients with 12 or more consecutive opioid-negative urine specimens was 36 percent in the levomethadyl acetate group, 26 percent in the buprenorphine group, 28 percent in the high-dose methadone group, and 8 percent in the low-dose methadone group (P=0.005). At the time of their last report, patients reported on a scale of 0 to 100 that their drug problem had a mean severity of 35 with levomethadyl acetate, 34 with buprenorphine, 38 with high-dose methadone, and 53 with low-dose methadone (P=0.002). CONCLUSIONS As compared with low-dose methadone, levomethadyl acetate, buprenorphine, and high-dose methadone substantially reduce the use of illicit opioids.
The Relationship Between Teacher Candidates' Performance on Praxis I and Praxis II in New Jersey

iii ACKNOWLEDGMENTS.iv DEDICATION.v LIST OF TABLES.vii CHAPTER I: INTRODUCTION.1 Statement of the Problem.8 Purpose of the Study.14 Research Questions.17 Significance of the Study.17 Theoretical Framework.20 Limitations.23 Delimitations.25 Definitions of Terms.26 CHAPTER II: REVIEW OF RELATED LITERATURE.28 Historical Background.28 Admission to Teacher Preparation Programs.31 Grade Point Average.34 The Praxis Series®. 39 Minority Teacher Candidate Pool.45 Teacher Licensure and Certification in New Jersey.55 CHAPTER III: RESEARCH METHODOLOGY.61 Research Design.61 Methods.62 Research Population and Sampling. 63 Validity and Reliability of the Instrument.67 Data Collection.68 Data Analysis.71 CHAPTER IV: RESEARCH FINDINGS AND ANALYSIS.75 Model 1: Praxis I Passing Status.78 Model 2: Race/Ethnicity.83 Models 3 and 4: Academic Major and UGPA.84 Model 5: Praxis I, Races/Ethnicity, Academic Major, and UGPA.87 CHAPTER V: SUMMARY OF CONCLUSIONS AND RECOMMENDATIONS.91 Conclusions.92 Study Limitations.96 Recommendations for Policy and Practice.97 Recommendations for Future Research.99 References.103 Appendices.117
Comparison of ex‐vivo high‐resolution episcopic microscopy with in‐vivo four‐dimensional high‐resolution transvaginal sonography of the first‐trimester fetal heart

To compare the capability of three‐dimen‐sional (3D) reconstructed images produced by high‐resolution episcopic microscopy (HREM) with that of in‐vivo four‐dimensional high‐resolution transvaginal sonography (4D‐HRTVS) to discern morphological features of the first‐trimester human fetal heart.
A Health and Wellness Intervention for Those With Moderate to Severe Traumatic Brain Injury: A Randomized Controlled Trial

Objectives:To assess the efficacy of a standardized 12-week health and wellness group intervention for those with moderate to severe traumatic brain injury (TBI). Study Design:Randomized controlled trial. Participants:Seventy-four individuals with moderate to severe TBI recruited from the outpatient program at a rehabilitation hospital, a Veterans Affairs Medical Center, and the community. Method:Eligible participants were randomized to treatment (health and wellness therapy group) or wait-list control (treatment, n = 37; wait-list, n = 37). The primary outcome was the Health Promoting Lifestyle Profile-II. Results:The results of the mixed-model repeated-measures analysis indicated no differences between treatment and control groups engaging in activities to increase their health and well-being. Conclusions:Findings did not support the efficacy of the intervention. Results may have been impacted by the wide variability of individualized health and wellness goals selected by group members, the structure and/or content of the group, and/or the outcome measures selected.
Expression of smooth muscle alpha‐actin in mesenchymal cells during formation of avian endocardial cushion tissue: A role for transforming growth factor β3

During early cardiac morphogenesis, outflow tract (OT) and atrio‐ventricular (AV) endothelial cells differentiate into mesenchymal cells, which have characteristics of smooth muscle‐like myofibroblasts, and which form endocardial cushion tissue, the primordia of valves, and septa in the adult heart. During this embryonic event, transforming growth factor β3 (TGFβ3) is an essential element in the progression of endothelial‐transformation into mesenchyme. TGFβs are known to be a potent inducer for mesodermal differentiation and a promoter for differentiation of endothelial cells into smooth muscle‐like cells. Using a monoclonal antibody against smooth muscle‐specific alpha‐actin (SMA), we examined the immunohistochemical staining of this form of actin in avian endocardial cushion tissue formation. To determine whether TGFβ3 initiates the expression of SMA, the pre‐migratory AV endothelial monolayer was cultured with or without chicken recombinant TGFβ3 and the expression of SMA was examined immunochemically. Migrating mesenchymal cells expressed SMA beneath the cell surface membrane. These cells showed a reduction of endothelial specific marker antigen, QH1. Stationary endothelial cells did not express SMA. The deposition of SMA in the mesenchymal tissue persisted until the end of the fetal period. Pre‐migratory endothelial cells cultured in complete medium (CM199) that contained TGFβ3 expressed SMA, whereas cells cultured in CM199 alone did not. At the onset of the endothelial‐mesenchymal transformation, migrating mesenchymal cells express SMA and the expression of this form of actin is upregulated by TGFβ3. The induction of the expression of SMA by TGFβ3 is one of the initial events in the cytoskeletal reorganization in endothelial cells which separate from one another during the initial phenotypic change associated with the endothelial‐mesenchymal transformation. Dev. Dyn. 209:296–309, 1997. © 1997 Wiley‐Liss, Inc.