Miracle-dz/UniFAR-FTUs huggingface dataset:
CRYOACTIVATION FAILS TO AUGMENT PLASMA RENIN ACTIVITY IN THE CAT

1. Active and cryoactivated renin (plasma renin) activity after incubation at -5 degrees C for 4 days, were measured in cat plasma sampled before and during the following procedures: suprarenal aortic stenosis, electrical stimulation of the pons and mild hypotensive haemorrhage. 2. Under all experimental conditions the values of plasma renin activity for both the activated and non-activated samples were similar. 3. The absence of a cryoactivatable aliquot of renin suggests that in cat plasma the inactive form of the enzyme either is actually absent or has a liability to the action of cold different than in other animal species.
Cardiopulmonary arrest and resuscitation in Landrace/Large White swine: a research model

Sudden cardiac death (SCD) is a field of continuous research. In order to answer various questions regarding SCD, several animal models have been developed. The aim of the present study is to describe our experimental model of inducing cardiac arrest in Landrace/Large White pigs, and then resuscitated according to the International Guidelines on resuscitation. Fifteen Landrace/Large White pigs were anaesthetized and intubated while spontaneously breathing. The left and right jugular veins, as well as the femoral and the carotid arteries, were surgically prepared. Induction of cardiac arrest was achieved by using an ordinary rechargeable lithium battery, through a pacemaker wire inserted into the right ventricle. The typical Advanced Life Support (ALS) protocol was followed, and in case of restoration of spontaneous circulation, the animals were further evaluated for 30 min. Seven animals were successfully resuscitated using this protocol, whereas eight failed resuscitation efforts. Successful resuscitation was contingent on the restoration of the levels of coronary perfusion pressure and PETCO2 during chest compressions. Among the different ways of inducing cardiac arrest, the ordinary lithium battery is a simple, safe and valuable technique. Landrace/Large White pigs' baseline haemodynamics closely resemble human haemodynamics, making the breed a favourable model for resuscitation.
Antagonism between abscisic acid and gibberellins is partially mediated by ascorbic acid during seed germination in rice

The antagonism between abscisic acid (ABA) and gibberellin (GA) plays a key role in controlling seed germination,1,2 but the mechanism of antagonism during this process is not known. In the associated study,3 we investigated the relationship among ABA, reactive oxygen species (ROS), ascorbic acid (ASC) and GA during rice seed germination. ROS production is reduced by ABA, which hence results in decreasing ASC accumulation during imbibition. GA accumulation was also suppressed by a reduced ROS and ASC level, whereas application of exogenous ASC can partially rescue seed germination from ABA treatment. Further results show that production of ASC, which acts as a substrate in GA biosynthesis, was significantly inhibited by lycorine which thus suppressed the accumulation of GA. Consequently, expression of GA biosynthesis genes was suppressed by the low levels of ROS and ASC in ABA-treated seeds. These studies reveal a new role for ASC in mediating the antagonism between ABA and GA during seed germination in rice.
Physical-Layer Secrecy of MIMO Communications in the Presence of a Poisson Random Field of Eavesdroppers

This paper presents a probabilistic framework for physical layer secrecy of MIMO communications when the eavesdroppers channels and locations are unknown and modeled by Rayleigh fading and a Poisson point process, respectively. We first quantify the gain in probability of secrecy when using beamforming. Then, we study the case where, in addition to beamforming, artificial noise generation is employed to confuse the eavesdroppers.
Early upregulation of cyclooxygenase‐2 in human papillomavirus type 16 and telomerase‐induced immortalization of human esophageal epithelial cells

Background and Aim: Cyclooxygenase‐2 (COX‐2) plays an important role in the carcinogenesis of esophageal squamous cell carcinoma (ESCC). However, it is not clear whether COX‐2 is involved in the early or late stage of the development of ESCC. The aim of this study was to investigate the role of COX‐2 in the carcinogenesis of ESCC by an immortalized esophageal epithelial cell line.
Margaret McCartney: Game on for Pokémon Go

The game Pokemon Go is a “craze,” a “sensation. ” You use a smartphone in a virtual scavenger hunt for cartoon characters, but in real locations. It appeals to youngsters and kidults. Download the app; start walking. My youngest child is delighted that his mother willingly accompanies him for miles. The middle child is disgusted with our dedication to the cause, but also (I think) impressed with our plans for domination. My eldest is aghast: the popularity of Pokemon Go leads him to infer, just as Donald Trump ascends to presidential candidacy, that we’re at The End of Times. The …
Identification of the auditory hazards of extracorporeal shock wave lithotripsy

The aim of this work was to determine the effect of extracorporeal shock wave lithotripsy (ESWL) on the hearing of both patients and staff members exposed to such treatment. It used different hearing screening instruments, and compared the sensitivity of these instruments for the detection of the earliest change in hearing induced by this procedure. The results of this study show that ESWL has a potentially hazardous effect on hearing. This effect is subtle, could only be detected by transient evoked otoacoustic emissions (TEOAE), and is manifested in some of the subjects under study as temporary subjective hearing loss and tinnitus, reflecting a state of temporary biomechanical derangement of the outer hair cells. This effect seems to be related to the frequency of exposure to ESWL.
Supplementation of vitamins, probiotics and proteins on oxidative stress, enzymes and hormones in post-moult male broiler breeders

Abstract. This study was planned to investigate the comparative effect of vitamin E and C, probiotics, protein level and the combination of these treatments on body weight, serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), triiodothyronine (T3), thyroxine (T4), cortisol and some minerals in Zn-induced male broiler breeders. A total of 180 Hubbard male broiler breeders (65 weeks of age) were induced to moult. After moulting, the birds were randomly distributed into six groups. One group was fed vitamin E (100 IU/kg feed), second group was fed vitamin C (500 IU/kg feed), third group was fed probiotics (50 mg/L), fourth group was fed lower protein level (14 % crude protein) and the fifth group was fed the combination of the mentioned treatments. The sixth group served as control. The results revealed that serum TAC significantly increased (P
Insulitis in Human Type 1 Diabetes

Pancreatic tissues were analyzed immunohistologically in patients with autoimmune and fulminant type 1 diabetes (T1D) and control subjects. Both β and alpha cells were decreased in fulminant T1D, but only β cells were significantly decreased in autoimmune T1D. Insulitis was seen in both subtypes of T1D, but it remained longer in autoimmune than in fulminant T1D. Lymphocytic infiltration to the exocrine pancreatic tissue was observed only in fulminant T1D, whereas immunologically abnormal findings, such as increased expression of MHC class I molecule and Fas antigen in islet cells and Fas‐ligand expression in infiltrating lymphocytes, were detected only in autoimmune T1D. From these findings, together with clinical features, it could be concluded that in autoimmune T1D, β cells are assumed to be destroyed through a long‐standing autoimmune process, whereas in fulminant T1D, β cells seem to be destroyed very rapidly, probably by a destructive process triggered by viral infection.
A universal method for the detection and identification of Aphidiinae parasitoids within their aphid hosts

Molecular methods are increasingly used to detect and identify parasites in their hosts. However, existing methods are generally not appropriate for studying complex host–parasite interactions because they require prior knowledge of species composition. DNA barcoding is a molecular method that allows identifying species using DNA sequences as an identification key. We used DNA amplification with primers common to aphid parasitoids and sequencing of the amplified fragment to detect and identify parasitoids in their hosts, without prior knowledge on the species potentially present. To implement this approach, we developed a method based on 16S rRNA mitochondrial gene and LWRh nuclear gene. First, we designed two primer pairs specific to Aphidiinae (Hymenoptera), the main group of aphid parasitoids. Second, we tested whether the amplified regions could correctly identify Aphidiinae species and found that 61 species were accurately identified of 75 tested. We then determined the ability of each primer pair to detect immature parasitoids inside their aphid host. Detection was earlier for 16S than for LWRh, with parasitoids detected, respectively, 24 and 48 h after egg injection. Finally, we applied this method to assess parasitism rate in field populations of several aphid species. The interest of this tool for analysing aphid‐parasitoid food webs is discussed.
Linguistic indicators of wives' attachment security and communal orientation during military deployment.

Military deployment affects thousands of families each year, yet little is known about its impact on nondeployed spouses (NDSs) and romantic relationships. This report examines two factors-attachment security and a communal orientation with respect to the deployment-that may be crucial to successful dyadic adjustment by the NDS. Thirty-seven female NDSs reported on their relationship satisfaction before and during their partner's deployment, and 20 also did so 2 weeks following their partner's return. Participants provided a stream-of-consciousness speech sample regarding their relationship during the deployment; linguistic coding of sample transcripts provided measures of each participant's (a) narrative coherence, hypothesized to reflect attachment security with respect to their deployed spouse; and (b) frequency of first person plural pronoun use (we-talk), hypothesized to reflect a communal orientation to coping. More frequent first person plural pronounuse-we-talk-was uniquely associated with higher relationship satisfaction during the deployment, and greater narrative coherence was uniquely associated with higher relationship satisfaction during postdeployment. Discussion centers on the value of relationship security and communal orientations in predicting how couples cope with deployment and other types of relationship stressors.
The Prevalence of Menstrual Disorders in Psychiatric Patients

A recent survey (Coppen and Kessel, 1963) of a random sample of 500 women from the general population investigated the prevalence of common menstrual symptoms and their relationship to personality as assessed by the Maudsley Personality Inventory (M.P.I.). The results showed that certain of these common symptoms have a positive and significant correlation with the Neuroticism scale of the M.P.I. ; this was particularly notable for the symptoms of the premenstrual syndrome, i.e. premenstrual depression, irritability, swelling, etc., as well as for menstrual irregularity. Dysmenorrhoea, to the contrary of previous reports, showed no such association with neuroticism in this general population sample. The age and parity of the subjects were also found to influence the prevalence of many of these symptoms.
A multipath intensity profile model for residential environments

We describe a statistical model for the multipath intensity profile (MIP) in residential environments. The work is based on over 300,000 frequency response measurements at 712 locations in 23 homes. We show that, for non-line-of-sight (NLS) path, the MIP is well-modeled as a decaying exponential vs. delay, multiplied by a lognormal process over delay; and that a similar model applies to line-of-sight (LOS) paths. Moreover, we present simple statistical descriptions for the parameters of these functions.
Herpes simplex virus: receptors and ligands for cell entry

Entry of herpes simplex virus (HSV) into cells depends upon multiple cell surface receptors and multiple proteins on the surface of the virion. The cell surface receptors include heparan sulphate chains on cell surface proteoglycans, a member of the tumor necrosis factor (TNF) receptor family and two members of the immunoglobulin superfamily related to the poliovirus receptor. The HSV ligands for these receptors are the envelope glycoproteins gB and gC for heparan sulphate and gD for the protein receptors and specific sites in heparan sulphate generated by certain 3‐O‐sulfotransferases. HSV gC also binds to the C3b component of complement and can block complement‐mediated neutralization of virus. The purposes of this review are to summarize available information about these cell surface receptors and the viral ligands, gC and gD, and to discuss roles of these viral glycoproteins in immune evasion and cellular responses as well as in viral entry.
The Shape Modification Method of Combined Subdivision Surface Based on Catmull-Clark

Two methods is proposed to modify the shape of combined subdivision surface. One is to realize the shape modification of the combined subdivision surface by editing the curve network and updating the surface by the overlapping subdivision method, and the other one combines vertex constraint with the shape optimization method based on discrete PDE(partial differential equation), and realizes the shape modification of inner surface far away from the interpolating curves. The two methods effect on combined subdivision surface's different areas during shape modification. They can complement each other to realize the shape modification of the combined subdivision successfully.
Multiple probes are required to explore and control the rugged energy landscape of RNA hairpins.

Brownian dynamics simulations, as a function of temperature (T) and force (f) show that RNA hairpins form by multiple pathways thus revealing the rugged nature of the free-energy landscape. While low dimensional free-energy profiles can account for some aspects of thermodynamics of hairpin formation they cannot account for the observed pathway diversity during the refolding process. Thus, a single free-energy surface cannot be used to infer the experimentally observed multistate kinetics in hairpin formation in nucleic acids. The profound differences between the kinetics of folding upon f- and T-quench is due to the slow rate of loop nucleation when the search for the native conformation commences from stretched conformations as is the case upon f-quench.
A simulation-optimisation study for comparison of new logistics systems at Le Havre Port

This paper presents a comparison of two logistic systems including an intermediate platform for the collection and delivery of containers with the maritime container terminals in Le Havre Port area. The first one uses a conventional operational organization of a set of rail shuttles. The second one SFM (`Service Ferroviaire Modulaire': modular rail service) is based on the first but with teleoperated railcars able to make local maneuvers in maritime terminals and in logistical centers without requiring a locomotive. We built a simulation model representing the whole system. Several scenarios and management rules are developed with an integrated optimization modules are used to find the correct values of exploitation parameters. The results are reported and analyzed to highlight the efficiency of each logistics system.
Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS

The transcriptional adaptive response of motoneurons and muscles to voluntary exercise has been investigated by using laser capture microdissection and microarray analysis. Our results show that motoneurons respond to physical activity by activating a complex transcriptional plan, with changes involved in neurotrophic factor signalling, electrophysiological changes and synaptic reorganization. Gastrocnemius muscle shows increases in transcripts responsible for neovascularization and new myogenesis. Both tissues show transcriptional changes involved in the growth and reinforcement of the neuromuscular junction. This study indicates that the neuromuscular system undergoes significant structural and functional alterations, aiming to optimize the transmission of both chemical and electrical stimuli, thus prompting axonal outgrowth and mechanisms similar to long‐term potentiation in hippocampal neurons. Understanding the response of these cells during exercise has potentially important implications for human neuromuscular disease, including amyotrophic lateral sclerosis, by highlighting candidate genes pivotal for the balance between the physiology and the pathology of the neuromuscular system in terms of the stress response to physical exercise.
Effects of Enflurane on Haemodynamics and Oxygen Consumption in the Dog with Special Reference‐ to the Liver and Preportal Tissues

The effects of enflurane anaesthesia on central circulation, total oxygen uptake, splanchnic circulation and splanchnic oxygen uptake were studied in 10 artificially ventilated dogs, basally anaesthetized with thiopental and nitrous oxide. Hepatic arterial, superior mesenteric arterial and portal venous blood flows were measured with electromagnetic flowmetry. Cardiac output was measured by thermodilution. Determinations of oxygen contents were made in arterial, pulmonary arterial, portal venous and hepatic venous blood. The end‐tidal enflurane concentration was kept at about 1 MAC (= 2.2%). Arterial blood pressure diminished to 54% of control value due to decreases of cardiac output to 65% and of total peripheral vascular resistance to 81% of control values. Hepatic arterial, superior mesenteric arterial and portal venous blood flows decreased to 65–70% of control levels and the corresponding vascular resistances all declined to about 80–85% of control values. Total oxygen uptake decreased, but less than cardiac output, leading to an increased arterio‐venous oxygen content difference. Oxygen uptake of the preportal tissues was unchanged and hepatic oxygen uptake was not significantly altered, although there were decreases in hepatic oxygen uptake in some of the individual experiments. It is suggested that the cardiovascular depression following enflurane anaesthesia in the dog was due, to a great extent, to a primary myocardial depression. It is further roncluded that the splanchnic blood flows were relatively well preserved, due to decreases in splanchnic vascular resistancm, and that hepatic and preportal tissue oxygen consumptions were maintained by increased oxygen extraction.
The frequency of Pseudoexfoliation in a region of Greece (Epirus)

Abstract A study of Pseudoexfoliation syndrome frequency has been evaluated in the northwest of Greece (Epirus). In 700 examined patients (≥ 50 years old) Pseudoexfoliation was found in 170 (24.3%). The frequency of Pseudoexfoliation increases with age; no difference was noticed between sexes. Ocular hypertension (>22 mmHg) was found in 39.5% of the patients.
Dynamic Partitioning and the Conventionality of Kinds*

Lewis sender‐receiver games illustrate how a meaningful term language might evolve from initially meaningless random signals (Lewis 1969; Skyrms 2006). Here we consider how a meaningful language with a primitive grammar might evolve in a somewhat more subtle sort of game. The evolution of such a language involves the co‐evolution of partitions of the physical world into what may seem, at least from the perspective of someone using the language, to correspond to canonical natural kinds. While the evolved language may allow for the sort of precise representation that is required for successful coordinated action and prediction, the apparent natural kinds reflected in its structure may be purely conventional. This has both positive and negative implications for the limits of naturalized metaphysics.
Estimation of maximum oxygen uptake from submaximal exercise on a Concept II rowing ergometer.

The purpose of this study was to develop a submaximal test, on the Concept II rowing ergometer, to estimate the maximum oxygen uptake (VO2 max) of male rowers and non-rowers. Eleven rowers and 14 non-rowers completed a submaximal and a maximal rowing test. The submaximal test consisted of exercising for 6 min at five different incremental speeds with at least 6 min recovery between each speed. Speed, heart rate and oxygen uptake were monitored during the last minute of each increment. In the maximal test, the subjects were asked to row for 6 min at a speed calculated to elicit 105 degrees, of their predicted maximum heart rate (HRmax). The HRmax was predicted from 220 beats min-1-age. Actual HRmax was recorded and the highest value of oxygen uptake measured was regarded as the subject's VO2 max. An analysis of covariance revealed that the data collected for rowers and non-rowers had to be considered separately. The greatest differences were seen for the submaximal speed-VO2 relationship, which showed that the rowers were more efficient on the ergometer than the non-rowers. Measured HRmax was found to average 9 beats min-1 below the predicted HRmax. The measured VO2 max values for the whole group averaged 4.16 +/- 0.64 1 min-1 (mean +/- S.D.). A nomogram was developed to predict VO2 max. At an exercise intensity of 80-90% HRmax, the average estimated VO2 max, using predicted HRmax calculated from 220 beats min-1-age, was 4.34 +/- 0.7 1 min-1. (ABSTRACT TRUNCATED AT 250 WORDS)
Time course of muscular, neural and tendinous adaptations to 23‐day unilateral lower‐limb suspension in young men

Muscles and tendons are highly adaptive to changes in chronic loading, though little is known about the adaptative time course. We tested the hypothesis that, in response to unilateral lower limb suspension (ULLS), the magnitude of tendon mechanical adaptations would match or exceed those of skeletal muscle. Seventeen men, (1.79±0.05 m, 76.6±10.3 kg, 22.3±3.8 years underwent ULLS for 23 days (n=9) or acted as controls (n=8). Knee extensors (KE) torque, voluntary activation (VA), cross‐sectional area (CSA) (by magnetic resonance imaging), vastus lateralis fascicle length (Lf) and pennation angle (vartheta), patellar tendon stiffness and Young's modulus (by ultrasonography) were measured before, during and at the end of ULLS. After 14 and 23 days, (i) KE torque decreased by 14.8±5.5% and 21.0±7.1%, respectively (P<0.001); (ii) VA did not change; (iii) KE CSA decreased by 5.2±0.7% (P<0.001) and 10.0±2.0% (P<0.001); Lf decreased by 5.9% (NS) and 7.7% (P<0.05) and vartheta by 3.2% (P<0.05) and, (iv) tendon stiffness and modulus decreased by 9.8±8.2% (P<0.05) and 9.2±8.2% (P<0.05) at 14 days, and by 29.3±11.5% (P<0.005) and 30.1±11.9% (P<0.01) at 23 days, with no changes in the controls. Hence, ULLS induces rapid losses of KE muscle size, architecture and function, but not in neural drive. Significant deterioration in tendon mechanical properties also occurs within 2 weeks, exacerbating in the third week of ULLS. Rehabilitation to limit muscle and tendon deterioration should probably start within 2 weeks of unloading.