Miracle-dz/UniFAR-FTUs huggingface dataset:
A pH‐Mediated Electronic Wound Dressing for Controlled Drug Delivery

Topical administration of drugs in a timely manner according to the physiological need at the wound site can enhance the healing rate of chronic wounds. Herein, an electronic wound dressing that enables active topical drug delivery in response to electrically induced pH change is demonstrated for potential treatment of chronic wounds. In this platform, the pH of the dressing is controlled using an electrical field. This allows precise electrical control over the temporal profile of pH‐mediated drug release. This engineered dressing is comprised of microfabricated electrodes serving as anode and cathode, a pH sensitive hydrogel, and controlled electronic circuitry. The anode is coated with a pH sensitive poly(ethylene glycol)‐diacrylate/Laponite hydrogel layer containing drug loaded chitosan nanoparticles (ChPs). Applying a DC voltage between the electrodes results in a local change in pH near the electrodes. In basic environments found near the anode, the ChPs release their drug due to the dehydration process, while in acidic environments the release profile is negligible. Turning off the DC voltage results in immediate pH recovery and cessation of drug release. The biocompatibility of the dressing has also been confirmed—the pH shift resulting from application of DC voltage does not affect the wound pH significantly.
Impact of a non-return-to-work prognostic model (WORRK) on allocation to rehabilitation clinical pathways: A single centre parallel group randomised trial

Introduction Stratified medicine might allow improvement of patient outcomes while keeping costs stable or even diminishing them. Our objective was to measure if a prediction model, developed to predict non-return to work (nRTW) after orthopaedic trauma, improves the allocation to various vocational pathways for use in clinical practice. Material and methods Randomised-controlled trial on vocational inpatients after orthopaedic trauma (n = 280). In the intervention group, nRTW risk (estimated using the WORRK tool) was given to the clinician team before allocation of vocational pathways, while in the control group it was not. Three pathways were available: simple, coaching and evaluation (EP). Accompanying indications for interpretation of the nRTW risk were given. The primary outcome was the proportion of patients allocated to the EP. The secondary outcome was patients’ and clinicians’ satisfaction. Results 450 patients were assessed for eligibility, 280 included, 139 randomized to the control group (mean age 42.3years) and 141 to the intervention group (43.2years). The two groups had a similar risk profile. The patients in the intervention group were more often referred to the EP compared to the control group, but not statistically significantly more (risk ratio 1.31 [95% CI 0.70–2.46]). The number needed to treat was 30. When considering patients transferred to different pathways during rehabilitation, more patients from the intervention group were transferred to the EP over the course of the rehabilitation, increasing the risk ratio to 1.57 [95% CI 0.89 to 2.74]. Discussion The knowledge of the risk of nRTW has an influence, that is not however statistically significant and is without clinical importance as previously defined by our own power calculations (based on a 15% increase in referral to EP in the intervention group compared to the control group), on clinical decision making with regards to the allocation of patients to different physical and vocational rehabilitation programs after orthopaedic trauma. This influence is less than what was expected, possibly due to insufficient directive guidelines accompanying the WORRK model, or because clinicians associate less hours of therapy (as with certain rehabilitation programs) to disadvantaging the patient. These findings do, however, support the multi-factorial aspect of clinician decision-making.
An Antenna With a Stair-Like Ground Branch for Octa-Band Narrow-Frame Mobile Phone

An antenna with a small nonground portion (56 × 5 mm<sup>2</sup>) for 5.7 in octa-band mobile phones is presented in this letter. Owing to the stair-like ground branch, the width of the nonground portion is 5 mm (0.013 <italic>λ<sub>g</sub></italic> at frequency 0.8 GHz), and the area of ground clearance is only 280 mm<sup>2</sup> . By utilizing the space with a small value of the electric field, the antenna's size can be reduced without worsening the performance. The optimized structure can generate the high band that covers GSM1800, GSM1900, UMTS, LTE2300, and LTE2500 bands (1710–2690 MHz). Moreover, a double-resonant mode is generated in the low band for LTE700, GSM850, and GSM900 bands (704–960 MHz). A prototype is fabricated, and the measured −6 dB impedance bandwidths are 310 MHz (690–1000 MHz) and 1270 MHz (1680–2950 MHz). Meanwhile, the measured patterns, efficiencies, and gains are also obtained. This antenna is promising to utilize in the future.
Characterization of capsule genes in non-pathogenic Neisseria species

The genus Neisseria comprises a diverse group of commensal bacteria, which typically colonize the mucosal surfaces of humans and other animals. Neisseria meningitidis, the meningococcus, is notable for its potential to cause invasive meningococcal disease (IMD) in humans; however, IMD is comparatively rare, and meningococci normally colonize the nasopharynx asymptomatically. Possession of a polysaccharide capsule has been shown to be a prerequisite for disease in almost all IMD cases, and was previously considered unique to N. meningitidis, and potentially acquired by horizontal genetic transfer (HGT). Nevertheless, the capsule must also have some role in asymptomatic colonization and/or transmission, consistent with the existence of six non-disease-associated meningococcal capsule serogroups. In this study, full complements of putative capsule genes were identified in non-pathogenic Neisseria species, including Neisseria subflava and Neisseria elongata. These species contained genes for capsule transport and translocation homologous to those of N. meningitidis, as well as novel putative capsule synthesis genes. Phylogenetic analyses were consistent with the proposal that these genes were acquired by the meningococcus through HGT. In contrast with previous evolutionary models, however, the most parsimonious explanation of these data was that capsule transport genes had been lost in the common ancestor of the meningococcus, gonococcus, and their close relatives, and then reacquired by some meningococci. The most likely donor of the meningococcal transport genes was another Neisseria species.
Debugging native extensions of dynamic languages

Many dynamic programming languages such as Ruby and Python enable developers to use so called native extensions, code implemented in typically statically compiled languages like C and C++. However, debuggers for these dynamic languages usually lack support for also debugging these native extensions. GraalVM can execute programs implemented in various dynamic programming languages and, by using the LLVM-IR interpreter Sulong, also their native extensions. We added support for source-level debugging to Sulong based on GraalVM's debugging framework by associating run-time debug information from the LLVM-IR level to the original program code. As a result, developers can now use GraalVM to debug source code written in multiple LLVM-based programming languages as well as programs implemented in various dynamic languages that invoke it in a common debugger front-end.
Follicular Helper T Cells in Systemic Lupus Erythematosus

CD4+ follicular helper T (Tfh) cells constitute a subset of effector T cells that participate in the generation of high-affinity humoral responses. They express the chemokine receptor CXCR5 and produce the cytokine IL-21, both of which are required for their contribution to germinal center formation. Uncontrolled expansion of Tfh cells is observed in various mouse models of systemic autoimmune diseases and in patients with these diseases. In particular, the frequency of circulating Tfh is correlated with disease activity and anti-DNA antibody titer in patients with systemic lupus erythematosus. Recent studies reveal functional diversity within the Tfh population in both humans and mice. We will summarize here the molecular mechanisms for Tfh cell generation, survival and function in both humans and mice, and the relationship between Tfh cells and autoimmune disease in animal models and in patients.
An Intrusion Detection System for Cyber Attacks in Wireless Networked Control Systems

In this brief, a proposed topology for a wireless networked control system is studied under several cyber attack scenarios, and a distributed intrusion detection system (IDS) is designed to identify the existence of attacks. More specifically, this brief presents a modelling framework for the closed-loop control system with the IDS and a computational procedure to design and compute the IDS. The computational procedure delivers a stable closed-loop control system with the IDS being sensitive to cyber attacks. Also, a simulation example is used to illustrate the application of the proposed procedure as well as its effectiveness.
NAD-Glycohydrolase Depletes Intracellular NAD+ and Inhibits Acidification of Autophagosomes to Enhance Multiplication of Group A Streptococcus in Endothelial Cells

Group A Streptococcus (GAS) is a human pathogen causing a wide spectrum of diseases, from mild pharyngitis to life-threatening necrotizing fasciitis. GAS has been shown to evade host immune killing by invading host cells. However, how GAS resists intracellular killing by endothelial cells is still unclear. In this study, we found that strains NZ131 and A20 have higher activities of NADase and intracellular multiplication than strain SF370 in human endothelial cells (HMEC-1). Moreover, nga mutants of NZ131 (SW957 and SW976) were generated to demonstrate that NADase activity is required for the intracellular growth of GAS in endothelial cells. We also found that intracellular levels of NAD+ and the NAD+/NADH ratio of NZ131-infected HMEC-1 cells were both lower than in cells infected by the nga mutant. Although both NZ131 and its nga mutant were trapped by LC3-positive vacuoles, only nga mutant vacuoles were highly co-localized with acidified lysosomes. On the other hand, intracellular multiplication of the nga mutant was increased by bafilomycin A1 treatment. These results indicate that NADase causes intracellular NAD+ imbalance and impairs acidification of autophagosomes to escape autophagocytic killing and enhance multiplication of GAS in endothelial cells.
Binary Weighted Memristive Analog Deep Neural Network for Near-Sensor Edge Processing

The memristive crossbar aims to implement analog weighted neural network, however, the realistic implementation of such crossbar arrays is not possible due to limited switching states of memristive devices. In this work, we propose the design of an analog deep neural network with binary weight update through backpropagation algorithm using binary state memristive devices. We show that such networks can be successfully used for image processing task and has the advantage of lower power consumption and small on-chip area in comparison with digital counterparts. The proposed network was benchmarked for MNIST handwritten digits recognition achieving an accuracy of approximately 90%.
Patient Governance in a Patient-Powered Research Network for Adult Rheumatologic Conditions

Background: Patient-Powered Research Networks (PPRNs) are a unique type of patient-powered patient registry for patient-centered outcomes research requiring that stakeholder engagement play a key role in governance (eg, research guidance and decision making). The purpose of this report is to describe the governance structure of a newly formed PPRN and the activities undertaken prelaunch and postlaunch to evaluate and improve the engagement of patient stakeholders in governance. Methods: During the 18-month start-up period of ArthritisPower, a PPRN for adult rheumatologic conditions, 12 members of the patient body of the PPRN governance completed a 12-item preassessment and postassessment based on the Patient-Centered Outcomes Research Institute (PCORI) Engagement Rubric. The assessment was intended to measure Patient Governor (PG) perceptions of their engagement in governance within the first 3 months of their involvement at an in-person orientation. Six months later, the PG Chair initiated a mid-year evaluation with the same group to identify areas for improvement. Semistructured phone interviews were conducted with 11 PGs who were asked to rate and explain their perceptions about their participation in PPRN governance, the progress of the PPRN toward conducting research, the support they receive from staff, and the support they receive from other PGs. Results were compiled and interpreted by the Chair with help from the coprincipal investigator. Results: Preassessment/postassessments indicated that PGs understood their governance role and decision-making authority after in-person orientation and felt that major PPRN decisions were being made with their input. Feedback and scores from the PG-led mid-year evaluation coalesced around 3 themes: a preference for receiving news and updates via email to allow more discussion and decision making during conference calls, a desire for guidance about how best to help advance the PPRN toward the conduct of research, and a need to communicate with each other as a group outside of monthly conference calls. Suggested activities to support patient engagement in PPRN governance include communicating clear expectations, providing well-prepared tools for engagement, and conducting regular assessments. Conclusions: Members of an online patient community are willing to share their expertise to participate in and shape research governance and bring both their professional and lived health experience to the development and improvement of PPRN governance structure. A patient-initiated and patient-led evaluation of governance communication procedures within the PPRN provided more specific recommendations for improvement than did an investigator-led preevaluation/postevaluation based on the PCORI Engagement Rubric.
Guidance on 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy from the Experience of a Single Nuclear Medicine Division

177Lu-DOTATATE is a radiolabeled somatostatin analog that has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of somatostatin receptor–positive gastroenteropancreatic neuroendocrine tumors in adults. Radionuclide therapies have been administered for many years within nuclear medicine departments in North America. However, in comparison to other radiotherapies, 177Lu-DOTATATE peptide receptor radionuclide therapy involves more planning, coordination, concomitant medication administration (antiemetic medications and amino acids), and direct patient care. To date, various methods have been used in multiple centers during the NETTER-1 trial and the provision of patient care. As participants in the phase 3 NETTER-1 trial and the subsequent expanded-access program for the administration of 177Lu-DOTATATE studies, as well as recently starting postapproval clinical care, we have administered 61 177Lu-DOTATATE therapies at the time of this manuscript submission (13 in the NETTER-1 trial, 39 in the expanded-access program, and 9 clinically) at the Dana-Farber Cancer Institute and here share our procedures, personnel training, and workflow to help other centers establish programs for this FDA-approved 177Lu-DOTATATE peptide receptor radionuclide therapy.
Contemporary role of liver biopsy in hepatocellular carcinoma

A correct diagnosis of hepatocellular carcinoma (HCC) in cirrhotic patients with focal liver lesions is one of the most important issues nowadays. Probably one of the oldest debates in the hepatology community is whether to perform liver biopsy (LB) in all cirrhotic patients with focal liver lesions. We now face a time when oncology is moving towards personalized medicine. According to the current European Association for the study of Liver diseases HCC guidelines, LB has only a minor role in the management of HCC. However, the current recommendations were made more than five years ago. As time has passed, the development of high-throughput molecular technologies has helped reveal the main molecular mechanism involved in HCC development and progression. Several subtypes of HCC, with both molecular and histological characterization, have been described. Importantly, some of these subtypes have prognostic impact. In the context of personalized treatment, the role of LB will be carefully reconsidered. Until then, it is mandatory to know the various techniques of LB, their performances, complications and limitations. The balance of risk and benefit defines many of the decisions that we make as providers of medical care. In this review, we discuss not only the risks associated with LB, but also the benefits of biopsy in various clinical scenarios. Not long from now, the role of LB will be reconsidered. It is possible that we will go back in time and once again use biopsy for HCC diagnosis. Then again, we may move back to the future to try to improve the use of liquid biopsy in the follow-up of HCC patients after various treatment modalities.
Organizing pneumonia resembling disease progression in a non-small-cell lung cancer patient receiving ceritinib

Rationale: Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), a distinct molecular entity, is highly sensitive to ALK tyrosine kinase inhibitors (TKIs) such as crizotinib or ceritinib. Interstitial lung disease is a rare (1.2%) pulmonary toxicity that can result from ALK TKIs, however, organizing pneumonia has not been reported to date. Patient concerns: A 45-year-old Korean female with ALK-rearranged metastatic lung adenocarcinoma underwent ceritinib treatment and exhibited a partial response, until she developed organizing pneumonia resembling disease progression. Diagnoses: Multiple rebiopsies confirmed the involvement of organizing pneumonia in the pathology. Interventions: Ceritinib was stopped and the patient was treated with intravenous antibiotics followed by oral antibiotics for two weeks. Outcomes: After recovering from organizing pneumonia, ceritinib was successfully rechallenged and the patient attained a complete response. Lessons: When a new mass-like lesion develops in the lungs of responding patients, benign lung conditions, including organizing pneumonia should be considered in differential diagnoses.
ITGA1 is upregulated in response to oxygen over time in a BMP4 model of trophoblast

Integrin alpha-1 (ITGA1) interacts with the extracellular matrix, particularly collagen type 1 and degraded laminin (Fazleabas et al. 1997). Extravillous trophoblasts (EVT) in the mature human placenta express ITGA1 as they invade from the anchoring villi deeply into the maternal endometrium and myometrium in weeks 8-13 of gestation (Zhou et al. 1993). Similarly, in the baboon, ITGA1 is expressed by invading cytotrophoblast (CTB) in the peri-implantation period (Fazleabas et al. 1997). This article is protected by copyright. All rights reserved.
Anthropometric Indices from Primary to High School in the West of Iran: Epidemiologic Trends

Examining the trend of anthropometric indices in children and adolescents in each region can be highly beneficial in providing effective strategies to improve the status of their growth. This study was conducted with the aim of determining the trend of anthropometric indices in students from primary to high school in the west of Iran. Data were collected using a demographic questionnaire and health certificates for anthropometric information of primary school students, and current anthropometric measurements with scale for high school students. Then, all of the data were analyzed in AnthroPlus and SPSS software. Of the 731 students, 350 were female and 381 were male. Mean height Z-score to age showed a significant reduction from primary to high school (from +0.0386 to −0.27416), and mean body mass index Z-score to age showed a significant increase (from −0.3916 to +0.1826). Prevalence of stunting and overweight/obesity in high school was 1.4 and 2.5 times higher than primary school, respectively, but the prevalence of wasting reduced by 2.3 fold. Girls were more affected by the increased trend of obesity and stunting compared to boys. Nutritional transition was evident in students. Healthcare policy-makers should design and implement a comprehensive health strategy to deal with this situation, especially in girls.
Brief Announcement: Beeping a Time-Optimal Leader Election

The beeping model is an extremely restrictive broadcast communication model that relies only on carrier sensing. In this model, we solve the deterministic leader election problem with an asymptotically optimal round complexity. Using this result, we obtain an asymptotically optimal randomized leader election algorithm for anonymous networks, as well as improved algorithms for symmetry-breaking and communication primitives. The techniques that we introduce give a new insight as to how local constraints on the exchangeable messages can result in efficient algorithms, when dealing with the beeping model.
Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL‐6/Stat3 signaling

Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide with poor prognosis. Numerous studies have attempted to explore alternative regimens aimed at reducing cancer stem cells (CSCs) without compromising the efficacy of conventional chemoradiotherapy. The present study sought to assess the effect of a natural compound honokiol on the reduction of elevated cancer stemness, metastatic capacity, and chemoresistance of oral carcinoma stem cells (OCSCs). Our results demonstrated that honokiol attenuated the cell survival and self‐renewal of OCSCs in a dose‐dependent manner. Moreover, honokiol downregulated the expression of 2 selective markers of OCSCs, ALDH1, and CD44, as well as the migration and invasion abilities, indicating its potential to suppress cancer stemness. We showed that honokiol reduced the secretion of IL‐6 and phosphorylation of STAT3, and the honokiol‐inhibited self‐renewal, invasion and colony formation were reversed by administration of IL‐6. Most importantly, our data demonstrated that honokiol was able to potentiate the effect of Cisplatin, leading to a lower proportion of OCSCs and the decreased cancer stemness features. Taken together, this study demonstrated the benefits of utilizing honokiol as an adjunct therapy for OSCC treatment.
Autonomic Orchestration of Containers: Problem Definition and Research Challenges

Today, a new technology is going to change the way cloud platforms are designed and managed. This technology is called container. A container is a software environment where to install an application or application component and all the library dependencies, the binaries, and a basic configuration needed to run the application. The container technology promises to solve many cloud application issues, for example the application portability problem and the virtual machine performance overhead problem. The cloud industry is adopting the container technology both for internal usage and as commercial offering. However, we are far away from the maturity stage and there are still many research challenges to be solved. One of them is container orchestration, that make it possible to define how to select, deploy, monitor, and dynamically control the configuration of multi-container packaged applications in the cloud. This paper presents the problem of autonomic container orchestration, analyze the state of the art solutions and discuss open challenges.