Miracle-dz/UniFAR-FTUs huggingface dataset:
Epidemiology of Joint Dislocations and Ligamentous/Tendinous Injuries among 2,700 Patients: Five-year Trend of a Tertiary Center in Iran.

Background The epidemiology of traumatic dislocations and ligamentous/tendinous injuries is poorly understood. In this study, we aimed to evaluate the prevalence and distribution of various dislocations and ligamentous/tendinous injuries in a tertiary orthopedic hospital in Iran. Methods Musculoskeletal injuries in an academic tertiary health care center in Tehran February 2005 to October 2010 were recorded. The demographic details of patients with pure dislocations and ligamentous/tendinous injuries were extracted and the type and site of injuries were classified according to their specific age/gender groups. Results Among 18,890 admitted patients, 628 (3.3%) were diagnosed with dislocations and 2.081 (11%) with ligamentous/tendinous injuries. The total male/female ratio was 4.2:1 in patients with dislocations and 1.7:1 in patients with ligamentous/tendinous injuries. Shoulder was the most prevalent site of dislocation (50.6%), followed by fingers (10.1%), toes (7.6%), hip (7.3%), and elbow (6.5%). Ankle was the most common site of ligamentous/tendinous injury (53.5%), followed by midfoot (12.3%), knee (8.3%), hand (7%), and shoulder (5%). The mean ages of the patients in dislocations and ligamentous/tendinous injuries were 35.0±18.2 and 31.3± 15.1, respectively. There was no seasonal variation. Conclusion Shoulder dislocation and ankle ligamentous injury are the most frequent injuries especially in younger population and have different distribution patterns in specific age and sex groups. Epidemiologic studies can help develop and evaluate the injury prevention strategies, resource allocation, and training priorities.
On coexistence between UWB and OFDM-MIMO systems

To guarantee the next generation narrow band systems from Ultra Wideband (UWB) interference, the coexistence issue between OFDM-MIMO system and UWB system is studied in the indoor environment, using physical layer model simulation method. Based on the corresponding standards, OFDM-MIMO and UWB system models are established with the SIMULINK tool. Considering the environment and system parameters, the effective isotropic radiate power (EIRP) limit can be calculated in the basis of system bit error rate (BER). Nine operation bands are selected to cover all that used by OFDM-MIMO based wireless systems. Analysis of the coexistence issue is performed not only in single UWB system situation, but also in aggregate scenario. Finally, a developed UWB spectrum mask is demonstrated, which provides a theoretical evidence to constitute Chinese UWB spectrum mask.
Changes in striatal dopamine metabolism after microsphere embolism in rats.

BACKGROUND AND PURPOSE Dopamine plays an important role in striatal function. The present study was undertaken to elucidate the pathophysiological changes in striatal dopamine metabolism after microsphere embolism. METHODS Microspheres (48 microns) were injected into the right internal carotid artery of rats. Extracellular levels of dopamine and its metabolites were measured by in vivo microdialysis with the aid of high-performance liquid chromatography. In vivo striatal tyrosine hydroxylation and turnover (catabolism) rate of dopamine were estimated on the first and third days after the embolism. These were estimated by measuring tissue dopa or dopamine content in the presence of either an aromatic L-amino acid decarboxylase inhibitor or a tyrosine hydroxylase inhibitor, respectively. RESULTS In the microdialysis study, a 190-fold increase in the release of dopamine from the right striatum was observed 40 minutes after microsphere embolism, whereas the striatal dopamine metabolites decreased during the first 180 minutes after the embolism. Microsphere embolism decreased the striatal dopamine content throughout the experiment (28 days), whereas it increased tissue dopamine metabolites on the first day, followed by a decline in the metabolites on the third day or later. The in vivo turnover rate of dopamine decreased both on the first and third days, whereas the in vivo tyrosine hydroxylation decreased only on the third day after the embolism. CONCLUSIONS The results suggest that microsphere embolism induces severe damage to striatal dopaminergic metabolism 3 to 28 days after the embolism. Dopamine synthesis may be more resistant to the embolism-induced ischemic insults than its catabolism.
Understanding Anthropometric Characteristics Associated With Performance in Manual Lifting Tasks

Abstract Beck, B, Middleton, KJ, Billing, DC, Caldwell, JN, and Carstairs, GL. Understanding anthropometric characteristics associated with performance in manual lifting tasks. J Strength Cond Res 33(3): 755–761, 2019—Manual lifting is an essential military job task and is commonly linked to occupational injury. Methods to reduce injury risk focus on ensuring that employees have the requisite physical capacity to safely conduct critical job tasks. The aim of this study was to investigate which anthropometric characteristics are associated with lifting performance to inform targeted training programs for job-critical lifting tasks. Sixty-three (42 men and 21 women) participants conducted 3 maximal lifts to a platform (pack lift to 1.5 m, box lift to 1.3 m and box lift to 1.5 m). A dual-energy x-ray absorptiometry scan was used to quantify anthropometric characteristics (body region–specific lean mass and fat mass). Although anthropometric measures were strongly associated with each other, multivariable linear regression revealed that a significant proportion of the total variation in lifting performance in each of the 3 tasks was explained by upper-arm lean mass (pack lift: &bgr; = 5.42, p < 0.001; box lift 1.3 m: &bgr; = 5.64, p < 0.001; box lift 1.5 m: &bgr; = 7.00, p < 0.001). Leg lean mass also significantly contributed to the variation of pack lift performance (&bgr; = 0.93, p = 0.01). When controlling for key anthropometric characteristics in these 3 tasks, separate analyses showed no significant effect of sex or stature on lift performance. These results suggest that the perceived limitations of stature and sex may be overcome by targeted training programs to improve specific physical characteristics associated with lifting performance.
Attachment Insecurity, Personality, and Body Dissatisfaction in Eating Disorders

The aim of this study is assessing interactions between attachment style and personality in predicting body dissatisfaction (BD). A total of 586 outpatients with eating disorders (EDs) were recruited: 101 with anorexia nervosa, restricting type; 52 with anorexia nervosa, binge-eating/purging type; 184 with bulimia nervosa, purging type; and 249 with an eating disorder not otherwise specified. Participants completed Temperament and Character Inventory, Body Shape Questionnaire, Beck Depression Inventory, and Attachment Style Questionnaire. An insecure attachment was found in all EDs, as well as in eating disorder not otherwise specified. In all diagnostic groups, need for approval, as measured by the Attachment Style Questionnaire and depressive symptomatology, was found to be the best predictor of BD. Personality traits are weaker predictors of BD. This study supports the hypothesis that attachment insecurity is directly correlated with BD, core element in predicting and perpetuating EDs, independently of personality. Implications for treatment are discussed.
Cleome arabica leaf extract has anticancer properties in human cancer cells

Abstract Context: Cleome arabica L. (Capparidaceae) is a desert plant widely distributed in the North part of Africa whose leaves are used in traditional medicine as a sedative for abdominal and rheumatic pains. Objectives: The anticancer activity of methanol Cleome arabica leaf extracts (CALE) is investigated in different human cancer cell lines. Materials and methods: Five different human cancer cell lines, representative of the most common cancers in Western countries (i.e., breast adenocarcinoma, colon carcinoma, neuroblastoma, hepatoma, cervix carcinoma) were treated with different concentrations of CALE (i.e., 1, 5, 10, 25, 50, 100 and 200 µg/ml). Cell viability and cell cycle were measured by using a hemocytometer chamber and a cytofluorimeter, respectively. Epidermal growth factor (EGF) was used as a positive control. Western blots were performed to evaluate the CALE effects on pathways involved in cell growth regulation and on apoptotic cascade activation. Results and conclusion: Our results confirm that CALE has a high content of polyphenolic compounds (i.e., 32.21 ± 3.44%), mainly as flavonoids (24.56 ± 4.67%). In all tested cell lines CALE treatment reduces cell number in a dose-dependent manner (ED50 = 175 ± 30 µg/ml). CALE (100 and 200 µg/ml) increases by three-fold the activation of the apoptotic cascade involving caspase-3 activation and the cleavage of its substrate poly(ADP-ribose) polymerase (PARP). Intriguingly, CALE treatment (200 µg/ml) also blocks EGF-induced cell growth by preventing the growth factor-triggered AKT and ERK phosphorylation. As a whole, these data strongly suggest that CALE possesses anticancer effects in all tested cancer cell lines.
Characterization of Ocular Surface Symptoms From Optometric Practices in North America

Purpose. This study characterized ocular symptoms typical of dry eye in an unselected optometric clinical population in the United States and Canada. Methods. Self-administered dry eye questionnaires, one for non–contact lens wearers (dry eye questionnaire) and one for contact lens wearers (contact lens dry eye questionnaire), were completed at six clinical sites in North America. Both questionnaires included categoric scales to measure the prevalence, frequency, diurnal severity, and intrusiveness of nine ocular surface symptoms. The questionnaires also asked how much these ocular symptoms affected daily activities and contained questions about computer use, medications, and allergies. The examining doctors, who were masked to questionnaire responses, recorded a nondirected dry eye diagnosis for each patient, based on their own diagnostic criteria. Results. The dry eye questionnaires were completed by 1,054 patients. The most common ocular symptom was discomfort, with 64% of non–contact lens wearers and 79% of contact lens wearers reporting the symptom at least infrequently. There was a diurnal increase in the intensity of many symptoms, with symptoms such as discomfort, dryness, and visual changes reported to be more intense in the evening. The 22% percent of non–contact lens wearers and 15% of contact lens wearers diagnosed with dry eye (most in the mild to moderate categories) reported symptoms at a greater frequency than those not diagnosed with dry eye. Conclusions. Our results show that symptoms of ocular irritation and visual disturbances were relatively common in this unselected clinical population. The intensity of many ocular symptoms increased late in the day, which suggested that environmental factors played a role in the etiology of the symptoms.
Pharmacokinetics and antiretroviral response to darunavir/ritonavir and etravirine combination in patients with high-level viral resistance

Background:Cumulative antiretroviral exposure can result in multiclass HIV drug resistance. Experimental antiretroviral agents offer limited therapeutic benefit as resistance quickly develops after their introduction as a sole new agent. Objective:To assess the pharmacokinetic profile, safety and virological response of two novel investigational antiretroviral agents when used in combination in HIV-1-infected subjects with multidrug-resistant virus. Methods:HIV-1-infected subjects, with current virological failure on a stable antiretroviral regimen with no viable treatment options were assigned to a regimen comprising two new investigational agents, etravirine, a novel nonnucleoside reverse transcriptase inhibitor, and darunavir, a novel protease inhibitor, plus nucleoside reverse transcriptase inhibitors (and enfuvirtide in selected patients) for 24 weeks. Virological, immunological and safety parameters were collected. Detailed pharmacokinetic assessments of darunavir and etravirine were determined on days 7 and 28. Results:Follow up of 24 weeks was achieved by 10/12 patients. Median reduction in HIV RNA was 2.7 log10 copies/ml (range, 2.3–3.9) and increase in CD4 lymphocytes was 113 cells/μl (range, 41–268). HIV RNA was < 40 copies/ml in nine. No serious adverse events were recorded. Plasma exposure to darunavir was similar to historic control data and exposure to etravirine similar to historic data when etravirine was administered with a boosted protease inhibitor. Conclusion:This first study to assess the use of etravirine and darunavir in HIV-1-infected subjects with no treatment options showed highly effective virological and immunological responses over 24 weeks of therapy with no new safety concerns or unexpected pharmacokinetic interactions.
Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons

Ras‐GAP SH3‐domain–binding protein, G3BP, is an important component in the assembly of stress granules (SGs), which are cytoplasmic aggregates assembled following translational stress. To assess the physiological function of G3BP, we generated viable G3bp1‐knockout (KO) mice, which demonstrated behavioral defects linked to the CNS‐associated with ataxia phenotype. Immunohistochemistry pinpointed high expression of G3BP in the cytoplasm of hippocampal neurons and Purkinje cells of the cerebellum of wild‐type mice. Also, electrophysiological measurements revealed that the absence of G3BP1 leads to an enhancement of short‐term potentiation (STP) and long‐term depression in the CA1 area of G3bp1 KO mice compared with wild‐type mice. Consistently, G3BP1 deficiency in neurons leads to an increase in intracellular calcium and calcium release in response to (S)‐3,5‐Dihydroxyphenylglycine, a selective agonist of group I metabotropic glutamate receptors. These results show, for the first time, a requirement for G3BP1 in the control of neuronal plasticity and calcium homeostasis and further establish a direct link between SG formation and neurodegenerative diseases.
Effects of ecstasy on cooperative behaviour and perception of trustworthiness: A naturalistic study

Background: Acute recreational use of 3,4-methylenedioxymethamphetamine (MDMA; ‘ecstasy’) can promote pro-social effects which may alter interpersonal perceptions. Aims: To explore such effects, this study investigated whether acute recreational use of ecstasy was associated with changes in individual perception of trustworthiness of people’s faces and co-operative behaviours. Method: An independent group, repeated measures design was used in which 17 ecstasy users were tested on the night of drug use (day 0) and again three days later (day 3); 22 controls were tested on parallel days. On each day, participants rated the trustworthiness of 66 faces, carried out three co-operative behaviour tasks (public good; dictator; ultimatum game) and completed mood self-ratings. Results: Acute ecstasy use was associated with increased face trustworthiness ratings and increased cooperative behaviour on the dictator and ultimatum games; on day 3 there were no group differences on any task. Self-ratings showed the standard acute ecstasy effects (euphoria, energy, jaw clenching) with negative effects (less empathy, compassion, more distrust, hostility) emerging on day 3. Conclusions: Our findings of increased perceived trustworthiness and co-operative behaviours following use of ecstasy suggest that a single dose of the drug enhances aspects of empathy. This may in turn contribute to its popularity as a recreational drug and potentially to its enhancement of the therapeutic alliance in psychotherapy.
The Language Application Grid and Galaxy

The NSF-SI2-funded LAPPS Grid project is a collaborative effort among Brandeis University, Vassar College, Carnegie-Mellon University (CMU), and the Linguistic Data Consortium (LDC), which has developed an open, web-based infrastructure through which resources can be easily accessed and within which tailored language services can be efficiently composed, evaluated, disseminated and consumed by researchers, developers, and students across a wide variety of disciplines. The LAPPS Grid project recently adopted Galaxy (Giardine et al., 2005), a robust, well-developed, and well-supported front end for workflow configuration, management, and persistence. Galaxy allows data inputs and processing steps to be selected from graphical menus, and results are displayed in intuitive plots and summaries that encourage interactive workflows and the exploration of hypotheses. The Galaxy workflow engine provides significant advantages for deploying pipelines of LAPPS Grid web services, including not only means to create and deploy locally-run and even customized versions of the LAPPS Grid as well as running the LAPPS Grid in the cloud, but also access to a huge array of statistical and visualization tools that have been developed for use in genomics research.
Molecular and cytogenetic investigation of Y chromosome deletions over three generations facilitated by intracytoplasmic sperm injection

The azoospermic factor (AZF) region is critical for normal spermatogenesis since microdeletions and partial deletions have been associated with infertility. We investigate the diagnostic ability of karyotyping in detecting clinically relevant Y chromosome deletions. The clinical significance of heterochromatin deletions, microdeletions and partial AZFc deletions is also evaluated.
A survey of the causes of mortality in adult mink, with emphasis on the lactation period.

A study of the pattern and relative frequency of diseases in adult female mink during the lactation period was undertaken. All adult females that died between parturition (April/May) and July 1, 1990, from 48 farms in southern Ontario were selected for study, and the cause of death was determined by gross necropsy. In addition, the cause of death was determined by gross necropsy for all adults and weaned kits that died on one farm between April 1988 and March 1989.The mortality rate among farms in the 1990 study, for adult females during the lactation period, ranged from 0.2% to 10.1%, with a median of 1.9%. Nursing disease (56%) was the most common diagnosis, followed by mastitis (11%), metritis (8%), and dystocia (7%). Escherichia coli and Staphylococcus spp. were the most frequent isolates from the cases of mastitis. In the 1988/1989 study, the mortality rate was highest from May to July, with a large increase in June as a result of nursing disease.
Research design and statistical methods in Chinese medical journals.

CONTEXT Study design and statistical analyses have improved in journals published in Western countries, but the type of research designs and statistical methods used in medical journals outside Western countries has not been assessed. OBJECTIVES To determine the frequency of research designs and statistical techniques used in Chinese medical journals, types of statistical errors present, and trends over a 10-year period. DESIGN Evaluation of all original articles published in 5 leading journals in 1985 (N = 640) and in 1995 (N = 954). MAIN OUTCOME MEASURES Research designs and statistical methods. RESULTS Compared with 1985, significant improvement was seen in 1995; the percentages of original articles reporting clinical trials, prospective studies, or basic science research increased from 18% to 31% (P<.001), the proportion of papers using statistical tests increased from 40% to 60% (P<.001), more sophisticated statistical methods were used, and of those articles using statistics, the proportion using appropriate methods increased from 22% to 46% (P<.001). In both years, the most commonly used statistical methods were t tests and contingency tables. The most common errors were presentation of P values without specifying the test used, use of multiple t tests instead of analysis of variance, and use of unpaired t tests when paired tests were required. CONCLUSIONS The use of statistical methods in Chinese medical journals research is improving, and by 1995, the frequency of using statistical methods in published articles was similar to the results determined in previous studies of journals. However, the lack of or inappropriate use of statistics remains a serious problem.
Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetron.

BACKGROUND Although all first-generation 5-HT(3) receptor antagonists demonstrate efficacy in preventing acute chemotherapy-induced nausea and vomiting (CINV), effective prevention of delayed CINV has not yet been achieved. This study compared the efficacy and tolerability of palonosetron, a novel, second-generation 5-HT(3) receptor antagonist, with ondansetron. PATIENTS AND METHODS In this multicenter, randomized, double-blind, stratified, phase III study, 570 adult cancer patients were randomized to receive a single i.v. dose of palonosetron 0.25 mg, palonosetron 0.75 mg or ondansetron 32 mg, each administered 30 min before initiation of moderately emetogenic chemotherapy. The primary end point was the proportion of patients with no emetic episodes and no rescue medication [complete response (CR)] during the 24 h after chemotherapy administration (acute period). Secondary end points included efficacy in treatment of delayed CINV (</=5 days post-chemotherapy) and overall tolerability. RESULTS 563 patients were evaluable for efficacy. CR rates were significantly higher (P <0.01) for palonosetron 0.25 mg than ondansetron during the acute (0-24 h) (81.0% versus 68.6%, respectively), delayed (24-120 h) (74.1% versus 55.1%) and overall (0-120 h) (69.3% versus 50.3%) periods. CR rates achieved with palonosetron 0.75 mg were numerically higher but not statistically different from ondansetron during all three time intervals. Both treatments were well tolerated. CONCLUSIONS A single i.v. dose of palonosetron 0.25 mg was significantly superior to i.v. ondansetron 32 mg in the prevention of acute and delayed CINV.
Variable delay multi‐pulse train for fast chemical exchange saturation transfer and relayed‐nuclear overhauser enhancement MRI

Chemical exchange saturation transfer (CEST) imaging is a new MRI technology allowing the detection of low concentration endogenous cellular proteins and metabolites indirectly through their exchangeable protons. A new technique, variable delay multi‐pulse CEST (VDMP‐CEST), is proposed to eliminate the need for recording full Z‐spectra and performing asymmetry analysis to obtain CEST contrast.