Miracle-dz/UniFAR-FTUs huggingface dataset:
The Acceptability and Efficacy of Electronic Data Collection in a Hospital Neurodevelopmental Clinic: Pilot Questionnaire Study

Background There is a growing need for cost-efficient and patient-centered approaches to support families in hospital- and community-based neurodevelopmental services. For such purposes, electronic data collection (EDC) may hold advantages over paper-based data collection. Such EDC approaches enable automated data collection for scoring and interpretation, saving time for clinicians and services and promoting more efficient service delivery. Objective This pilot study evaluated the efficacy of EDC for the Child Development Unit, a hospital-based diagnostic assessment clinic in the Sydney Children’s Hospital Network. Caregiver response rates and preference for EDC or paper-based methods were evaluated as well as the moderating role of demographic characteristics such as age, level of education, and ethnic background. Methods Families were sent either a paper-based questionnaire via post or an electronic mail link for completion before attending their first on-site clinic appointment for assessment. A total of 62 families were provided a paper version of the questionnaire, while 184 families were provided the online version of the same questionnaire. Results Completion rates of the questionnaire before the first appointment were significantly higher for EDC (164/184, 89.1%) in comparison to paper-based methods (24/62, 39%; P<.001). Within the EDC group, a vast majority of respondents indicated a preference for completing the questionnaire online (151/173, 87.3%), compared to paper completion (22/173, 12.7%; P<.001). Of the caregiver demographic characteristics, only the respondent’s level of education was associated with modality preference, such that those with a higher level of education reported a greater preference for EDC (P=.04). Conclusions These results show that EDC is feasible in hospital-based clinics and has the potential to offer substantial benefits in terms of centralized data collation, time and cost savings, efficiency of service, and resource allocation. The results of this study therefore support the continued use of electronic methods to improve family-centered care in clinical practices.
Antimicrobial Mechanism and Identification of the Proteins Mediated by Extracts from Asphaltum punjabianum and Myrtus communis

Myrtus communis (“myrtle”) and Asphaltum punjabianum (“shilajeet”) are a medicinal plant and a long-term-humified dead plant material, respectively. We studied their antibacterial and anticandidal activities against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Candida albicans. The activities of the aqueous extracts of the studied materials were measured using agar-well diffusion methods. Furthermore, proteomic analysis of treated microbial cells was conducted to identify affected proteins. The results showed both antibacterial and anticandidal activities for the myrtle extract (ME), while the shilajeet extract (SE) showed antibacterial activity only. The highest antimicrobial activity was observed against E. coli among the microbes tested; therefore, it was taken as the model for the proteomic analysis to identify the antimicrobial mechanism of ME and SE using two-dimensional electrophoresis. Upregulation of expression of 42 proteins and downregulation of expression of 6 proteins were observed in E. coli treated with ME, whereas 12 upregulated and 104 downregulated proteins were detected in E. coli treated with SE, in comparison with the control. About 85% of identified expressed proteins were from the cytoplasm and 15% from microbial cell walls, indicating the penetration of extracts inside cells. A higher percentage of expressed proteins was recorded for enzymatic activity. Our findings suggest that the major targets of the antibacterial action were proteins involved in the outer membrane, oxidative stress, and metabolism. Our data might reveal new targets for antimicrobial agents.
Evaluation of Surface Hygiene of the Surrounding Objects in a University Hospital

Research background. Hygiene of the surfaces means a clean environment of a hospital, especially that of a patient, which consists of constant basic cleaning and disinfection. The registration, analysis and storage of data on cleaning, disinfecting the surrounding objects is a successful stage in ensuring clean surfaces. The registration of documents and the cleaning and disinfecting schedule help to determine the tender spots in the surface cleaning. It makes easy to establish the surface hygiene violations, participation of the nursing and auxiliary staff in disinfecting the surfaces, problems related to the surface disinfection, and make the analysis of the mistakes made easier. The aim of the study. To assess a 2009–2011 hygienic preparation of medical surfaces, which have an effect on the transmission of the hospital-acquired infection, and the efficiency of the preventative measures. Methods. The survey was conducted in university hospital in 2009–2011. To evaluate the surface hygiene of the environmental objects the test of the remains of biological contamination was chosen using the chemical means HemoCheck-S™. The accuracy of the test is 0.1 µq of the remains of biological contamination on the surfaces under investigation. The results are evaluated by calculating the amount of denatured biological contamination from the highest concentration to 0. The surface contamination is evaluated in points from “0” to “5”, where “0” is no contamination (medical surface is fully prepared for a procedure), and “5” is maximum contamination (100 µq, maximum contamination shown by the HemoCheck-S™ test). Results. Investigation shows that the surfaces belonging to the low-risk group are contaminated most heavily. The analysis of the investigations carried out during three years leads us to the conclusion that during the time of cleaning the surface, the staff fails to observe the sequence and do not change soft inventory (napkins) intended for cleaning. This is testified by presence of biological contamination in the low-risk group: switch-boards on the patients’ beds, cupboards and drip mounts. Conclusions. Insufficient hygiene of high, medium risk and often touched surfaces and surfaces of nursing measures was established. The inadequate preparation of the medical surfaces was most often made in the Intensive Care Intensive Therapy units.Keywords: hygienic preparation; medical surfaces; the hospital-acquired infection.
Differential susceptibility to endocrine disruptor-induced epimutagenesis

Abstract There is now considerable evidence indicating the potential for endocrine disrupting chemicals to alter the epigenome and for subsets of these epigenomic changes or “epimutations” to be heritably transmitted to offspring in subsequent generations. While there have been many studies indicating how exposure to endocrine disrupting chemicals can disrupt various organs associated with the body’s endocrine systems, there is relatively limited information regarding the relative susceptibility of different specific organs, tissues, or cell types to endocrine disrupting chemical-induced epimutagenesis. Here we review available information about different organs, tissues, cell types, and/or cell lines which have been shown to be susceptible to specific endocrine disrupting chemical-induced epimutations. In addition, we discuss possible mechanisms that may be involved, or impacted by this tissue- or cell type-specific, differential susceptibility to different endocrine disrupting chemicals. Finally, we summarize available information indicating that certain periods of development display elevated susceptibility to endocrine disrupting chemical exposure and we describe how this may affect the extent to which germline epimutations can be transmitted inter- or transgenerationally. We conclude that cell type-specific differential susceptibility to endocrine disrupting chemical-induced epimutagenesis is likely to directly impact the extent to, or manner in, which endocrine disrupting chemical exposure initially induces epigenetic changes to DNA methylation and/or histone modifications, and how these endocrine disrupting chemical-induced epimutations can then subsequently impact gene expression, potentially leading to the development of heritable disease states.
The Analysis of Sustainable Supply Chain Risks Based on the FMEA Method in the Oil and Gas industry and Factors Affecting Risk Management

Supply Chain Sustainability is a new and highly influential debate that has drawn the attention of researchers in the field of supply chain management. This concept is particularly important in the oil and gas industry because of its nature and the risks and sustainability risks associated with this industry, especially environmental hazards. The purpose of this study was to evaluate the risks related to supply chain sustainability in the oil and gas industry based on the FMEA method. The statistical population of this study consisted of all experts familiar with the concept of sustainability in the oil and gas industry, out of which 10 experts were selected and surveyed through snowball sampling. The results showed that among the risks posed in the field of supply chain sustainability in the oil and gas industry, risks such as failure and pollution in surface (hydrological) and groundwater (hydrogeological) systems and flows, energy price fluctuations and sanctions as well as the emission of hazardous and greenhouse gases, the reduction of air quality and climate change were prioritized over other risks, as well as sustainability commitment (organizational culture, top management leadership and transparency), management readiness (risk management, cross-functional teams and performance management) and external factors (political stability, economic stability, stakeholder pressure, energy transition policies, and laws and regulations) can all play an important role in managing the risks associated with this industry.
Dehydrostephanine Isolated from Stephania venosa Possesses Anti-Inflammatory Activity in Lipopolysaccharide-Activated RAW264.7 Macrophages

Stephania venosa (Blume) Spreng. , is a medicinal herb wildly used as a folklore medicine in Thailand. Many studies have reported that S. venosa tuber revealed a variety of pharmacological activities including anti-malarial, anti-microbial, anti-cancer, anti-oxidant, and anti-inflammatory activities. In this study, we investigated the effects of (–)-stephanine and dehydrostephanine isolated from S. venosa tuber on anti-inflammation in lipopolysaccharide (LPS)-activated RAW264.7 macrophages. RAW264.7 cells were treated with (–)-stephanine and dehydrostephanine in the presence of LPS and cell viability was determined by MTT assay. The levels of inflammatory mediators, nitric oxide (NO) and pro-inflammatory cytokines were determined by Griess assay and enzyme-linked immunosorbent assay, respectively. Pre-treatment of dehydrostephanine significantly suppressed NO secretion in LPS-activated RAW264.7 cells with the half-maximal inhibitory concentration (IC 50 ) value of 26.81 ± 0.25 μM. However, (–)-stephanine had IC 50 value on the inhibition of NO secretion of >40 μM. In addition, dehydrostephanine at concentrations of 20–80 μM significantly reduced LPS-induced tumor necrosis factor-alpha, interleukin-1b and interleukin-6 production in RAW264.7 cells. The present study showed that dehydrostephanine possesses the anti-inflammatory effect on LPS-activated RAW264.7 macrophages by suppression of inflammatory mediators. Dehydrostephanine may be a promising candidate compound for further investigation of a novel class of anti-inflammatory drug.
Monolithic Integration of Phase-Change RF Switches in a Production SiGe BiCMOS Process with RF Circuit Demonstrations

We demonstrate for the first time the monolithic integration of phase-change RF switches into the backend of a production SiGe BiCMOS process. We show that the monolithic integration of PCM RF switches did not impact the performance of the BiCMOS process components, such as FETs and bipolar devices, by comparing end-of-line data for wafers fabricated with and without PCM RF switches. Using the backend RF components in the Tower Semiconductor SBC18H3B process, three different RF circuits were realized. A five bit DSC with 32 states is shown with a tuning range from 33 fF to 6.75 pF in ~215 fF increments. A wideband 24.25 GHz to 33.4 GHz switched filter using two SPDTs is also demonstrated. And finally, a tunable bandpass filter that uses seven phase change switches is shown to have tuning between 400 MHz up to 6 GHz.
A Study On Developing A Cyberbullying Scale For High School Students

Zorbalik; vurmak, itmek, engel olmak gibi fiziksel zorbalik, hakaret etme, lakap takma, utandirma gibi sozel zorbalik ve gruptan dislamak, arkasindan konusmak, arkadaslik iliskilerini bozmak gibi davranislari iceren duygusal zorbalik olarak siniflandirilmaktadir. Siber zorbalik da zorbaligin alt boyutlarindan birini olusturmaktadir. Bu calismanin amaci, ergenlerin siber zorbalik davranislarini olcmeye yonelik bir olcek gelistirmektir. Olcegin pilot calismasi, Zonguldak ilinde yer alan ortaogretim kurumlarinda ogrenim gormekte olan 231 ogrenci uzerinde yurutulmustur. Olcegin yapi gecerliligi icin acimlayici faktor analizi yapilmistir. Analiz neticesinde olcegin dort faktorlu bir yapi gosterdigi gorulmustur. Dort faktor toplam varyansin %66,235’ini aciklamaktadir. Bu faktorlerin guvenirlik katsayilarinin ise 0,58 ile 0,91 arasinda degistigi bulunmustur.
LA ECOLOGÍA POLÍTICA FEMINISTA Y COOPERATIVAS DIRIGIDAS POR MUJERES RURALES EN HIDALGO, MÉXICO

This study analyzes through feminist political ecology approach the gender strategies enacted by two peasant and indigenous rural women-led cooperatives in Hidalgo Mexico, to access and manage natural resources intersected by ethnicity and training. With a long-term longitudinal study, the interdependence between cooperative organization and climate change processes are explored. Time poverty, gender restriction for rural women, collective strategies to create productive autonomous space and identify stakeholders’ co-responsibility, are discussed. The cooperatives efforts in climate change processes in critical environments are highlighted by the approach.
Chemical Composition and Antimicrobial Activity of the Essential Oil of Verbascum thapsus L.

Abstract The composition of the essential oil obtained from the dried flowering aerial parts of Verbascum thapsus L. was analyzed by GC and GC-MS. Ninety-two components were identified in the essential oil of V. thapsus. The major components of the essential oil were 6,10,14-trimethyl-2-pentadecanone (14.3 %) and (E)-phytol (9.3 %). The antimicrobial activity of V. thapsus oil was studied using the disk diffusion method and determination of minimal inhibitory concentration (MIC) values. The V. thapsus oil exhibited concentration-dependent antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Salmonella typhi, Pseudomonas aeruginosa and Aspergilus niger. The essential oil did not show any antimicrobial activity against Escherichia coli and Candida albicans.
The Effect of Binding Commitments on Services Trade

Abstract It has long been established in theory that uncertainty impacts on firm behaviour. However, the empirical basis for quantifying the uncertainty-reducing effects of trade agreements has not been firmly established. In this paper, we develop estimates of the effect of reducing uncertainty regarding regulation of foreign services markets by making commitments that are bound under a trade agreement. Specifically, we identify the effect on services trade of services trade restrictions, as measured by the OECD's Services Trade Restrictiveness Index (STRI), and the separate effect of ‘water’ in binding commitments, as assessed by the difference between countries’ commitments under the General Agreement on Trade in Services (GATS) or free trade agreements (FTAs) and applied levels of market access, as captured by STRI scores. Using a gravity model, we find that services trade responds positively but inelastically to reductions in services trade barriers, as measured by the STRI and, in our preferred regression, the response to actual restrictions is more than twice – specifically 2.4 times – as strong as the response to comparable reductions in uncertainty, as measured by water. Moving from GATS commitments to FTA commitments leads to a 4.7% increase in services trade because of the reduction in uncertainty.
Identifying and Making Recommendations for Pediatric Anxiety Disorders in Primary Care Settings: A Video-Based Training

Introduction Pediatric anxiety disorders have high rates of prevalence and confer risk for later disorders if they go undetected. In primary care, they are underdiagnosed, partly because pediatricians often lack relevant training. We developed a brief, video-based training program for pediatric residents aimed at improving early identification of anxiety disorders in primary care. Methods Video content was consistent with the American Academy of Pediatrics Behavioral Health Competencies, as applied to the evaluation of anxiety disorders and guidance for discussing treatment options. This training can be delivered in two formats: videos (43 minutes) can be shown in a live, group-based format, or accessed via an online, asynchronous training. We tested this training program using both formats and developed surveys to evaluate knowledge about child anxiety, perceived evaluation skills, and satisfaction with the training. We also developed a video-based vignette to measure sensitivity to detecting disorders (how much the condition is interfering, diagnostic severity, and referral urgency). Results Pediatric residents from two residency programs completed the training and pre- and posttraining assessments to evaluate program efficacy. Residents’ knowledge and perceived evaluation skills increased posttraining, with large effect sizes. Residents also demonstrated increased sensitivity to detecting anxiety disorders on the vignette-based assessment and reported high levels of satisfaction. Discussion Our results suggested that residents participating in this training improved their evaluation skills and that residents found the training beneficial. Video-based trainings can significantly supplement existing education. This cost-effective and minimally burdensome training program can be used to enhance resident education in a much-needed area.
Calculations of the near-field enhancement in surface-enhanced Raman scattering on periodically structured metallic substrates

We study from a theoretical point of view the electromagnetic enhancement related to the surface enhanced Raman scattering on silver gratings. The local field is obtained by means of numerical calculations based on the rigorous coupled-wave analysis. Enhancements of up to 106 in the Raman signal of molecules adsorbed on these gratings could be obtained at the excitation wavelength (lambda) equals 514 nm.
Ask BERT: How Regulatory Disclosure of Transition and Physical Climate Risks affects the CDS Term Structure

We use BERT, an AI-based algorithm for language understanding, to quantify regulatory climate risk disclosures and analyze their impact on the term structure in the credit default swap (CDS) market. Risk disclosures can either increase or decrease CDS spreads, depending on whether the disclosure reveals new risks or reduces uncertainty. Training BERT to differentiate between transition and physical climate risks, we find that disclosing transition risks increases CDS spreads after the Paris Climate Agreement of 2015, while disclosing physical risks decreases the spreads. In addition, we also find that the election of Trump had a negative impact on CDS spreads for firms exposed to transition risk. These impacts are consistent with theoretical predictions and economically and statistically significant.
Relation between temperature memory effect and multiple-shape memory behaviors based on polymer networks

The temperature memory effect (TME) refers to the capability of shape memory materials to memorize the deformation temperature (Td). In this article, the TME of multiple-shape memory polymer based on a PMMA/PEG semi-interpenetrating polymer network (PMMA/PEG semi-IPN) and a PMMA-PCL covalently crosslinked polymer co-network (PMMA-PCL CPN) are studied, and the relation between the TME and the multiple-shape memory effect (SME) is investigated. The results indicate that both the PMMA/PEG semi-IPN and PMMA-PCL CPN can show the TME in a specific range of response temperatures but not in its entire range of glass transition temperatures (Tg). This paper further confirms that broad transition temperature is the key to realizing the TME and the multiple-SME. Furthermore, we discover that the characteristic temperature of the TME corresponds to the multi-step transition temperature of the multiple-SME for the first time. Consequently, the characteristic temperature of the TME can be directly used as a multi-gradient Td to achieve the multiple-SME. Thus it facilitates the selection of a multi-gradient Td in the multiple-SME. The paper also reveals the internal relation of broad Tg, TME and multiple-SME of PMMA/PEG semi-IPN and PMMA-PCL CPN.
Gel-combustion synthesis of Li1.2Mn0.4Co0.4O2 composites with a high capacity and superior rate capability for lithium-ion batteries

Owing to the merits of high capacity and low cost, Li-rich layered composite cathode materials have received extensive attention. Nevertheless, such materials always suffer from a poor rate capability, which seriously hinders their widespread practical applications. In this work, Li1.2Mn0. 4Co0.4O2 composites were fabricated by a gel-combustion method, in which lithium carbonates formed by an in situ burning reaction were homogeneously mixed with metal oxides, leading to excellent electrochemical properties. The sintering temperature and time were optimized to 900 °C and 15 h. The samples prepared at optimum conditions exhibited a high discharge capacity and excellent rate capability. At a current density of 20 mA g−1, the specific discharge capacity was 310.5 mA h g−1 for the first cycle and the capacity retention was 75.8% after 30 cycles. When the current densities increase by 10 times to reach 200 mA g−1, the initial discharge capacity is still as high as 241.4 mA h g−1, superior to that of 203 mA h g−1 at the same current density reported previously by the oxalate-precursor method. Even when the current densities increase by 20 times, the capacity remained as high as 203.7 mA h g−1, and the capacity retention was 79.4% over 30 cycles. The high discharge capacity and improved rate capability of the optimized sample were beneficial with a perfect layered structure with c/a >5.0, appropriate particle size of about 450 nm, high lithium ion diffusion coefficient around 1.42 × 10−13 cm2 s−1, and the presence of a maximum content of Mn3+ (11.6%), as determined by XPS. The preparation method reported herein may provide hints for obtaining various advanced Li-rich layered composite materials for use in high-performance energy storage and conversion devices.