Miracle-dz/UniFAR-FTUs huggingface dataset:
The Zemblanity of Missing Subtile Changes in the Patient'S Blood Tests-Diagnosing Hereditary Spherocytosis After Finding Extramedullary Haematopoiesis

Access Abstract We report a clinical case of hereditary spherocytosis in the view of it´s educational value. The diagnose was overlooked for many years while the patient was a regular blood donor. This was probably the stress factor that precipitated the development of extramedullary haematopoiesis in a patient that otherwise had a rather mild phenotype. The authors want to stress the importance of valuing the red cell indexes as an informative part of the
Misleading valproate dose-related reference ranges calculated by AGNP consensus guidelines 2017

AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology 2017 were recently published. In particular, definition and calculation of drug dose-related reference ranges (DRRR) were updated. However, calculation of DRRR with newly published dose-related concentration factors (DRC) for valproate lead to misleading, too high DRRR. Future pharmacokinetic studies that strongly control for confounding factors that may impact the pharmacokinetics of valproate were needed to receive appropriate pharmacokinetic data for the calculation of DRRR of valproate. We suggest for the next consensus update a DRCmean of approximately 52 ng/mL/mg. Thus, an approximately 50% reduction in DRCmean is recommended, as the DRCmean in the 2017 guidelines amounts 98.5 ng/ mL/mg. Currently, DRRR of valproate should be used with caution in clinical practice. Correspondence to: Gudrun Hefner, Vitos Klinik Hochtaunus, Emil-Sioli-Weg 1-3 61081 Friedrichsdorf, Germany, Tel: +49 (0)6123 602 7686 , Fax: +49 (0)6123 602 – 666, E-Mail: Gudrun.Hefner@vitos-rheingau.de
In vitro testing for allergic Rhinitis : economic and quality of life outcomes /

Allergic rhinitis and associated co-morbidities such as sinusitis, conjunctivitis, and asthma can significantly decrease patient health related quality of life and impose substantial economic costs. The etiology for rhinitis is complex, therefore effkient management of patient symptoms requires a correct objective diagnosis. Diagnosis of allergic rhinitis is often made through patient history and physical exam, with skin prick or in vitro testing providing a physician with additional information concerning the patients allergic state. In this work, we investigated the sensitivity and specificity of certain in vitro tested allergens (i.e., cat and common ragweed) in the absence of a gold standard. In addition, the association between patient demographics, in vitro based disease classification and allergy-related medicat charges, prescription charges, productivity, and quality of life were explored. The population for this study (n 330) included enrollees from a Midwestern managed care organization who had in vitro testing for inhalant allergies, in vitro laboratory results, along with medical and prescription claims associated with allergic rhinitis, were obtained from the managed care's database. In addition to obtaining laboratory test results and claims data. patients were asked to complete a survey containing severity of symptoms, productivity, and quality of life questions. A total of 232 subjects returned surveys, yielding a 70% response rate. Of the 232 subjects, 170 returned useable surveys (51% response rate of total subjects). The sensitivity and specificity of/n vitro allergy testing forçât were calculated to be 72.4% (credible inten/al: 66.0% • 78.3%) and 93.5% (credible interval: 91.8% 95.0%), respectively. The sensitivity and specificity of in vitro allergy testing for short ragweed were estimated to be 47.9% (credible interval: 34.8% 61.0%) and 98.5% (credible interval: 34.8% 61.0%). In vitro test status, age, gender, race, and severity of symptoms did not significantly explain allergy-related medical or prescription charges, however, overall allergy work impairment was positively associated with symptom severity. Additionally, study subjects had lower overall mental quality of life when compared to the average U.S. population. Further research is needed to assess the direct impact in vitro allergy testing has on medical costs, productivity, and quality of life.
Comparative Randomized Controlled Blind Study of the Anti-Shivering Effect of Hydrocortisone, Granisetron and Meperidine in Post-Spinal Anesthesia in Patients Undergoing Cesarean Section

Background: it was observed that a considerable proportion of patients undergoing surgery experience intraoperative and postoperative hypothermia and it was found that misregulation of body temperature due to anesthesia as well as the cold temperature of the operation room were the main cause. Purpose: to compare the anti-shivering effect of meperidine, hydrocortisone and granisetron after spinal anesthesia during elective cesarean section. Patients and Methods: this study presents a placebo-controlled prospective randomized blind study. Included patients were randomly (using computer generated randomization table) allocated into four equal groups each group consists of 28 patients. Results: in our study, age, sex, and ASA grade distribution of patients were nearly identical in the four groups. Furthermore, the duration of surgery and amount of irrigation fluid used in the four different groups were also similar. We did not observe a change in temperature gradient between the four groups. A study with a more prolonged duration of postoperative temperature monitoring is needed to note if core-periphery temperature changes occur with passage of time. Conclusion: the results indicate that IV granisetron 40 μg/kg was effective as IV meperidine 0.4 mg/kg and both are slightly effective than IV hydrocortisone 2 mg/kg in reducing the incidence and intensity of shivering during spinal anesthesia compared to control group.
Woody vegetation responses to fire versus clear-cutting logging: A comparative survey in the central Canadian boreal forest

AbstractThe woody vegetation of 131 clear-cut, postlogged boreal forest stands in central Canada, previously dominated by Picea mariana (Mill.) BSP. , is compared with 250 natural postfire stands from the same region. Each dataset represents a stand chronosequence on a range of substrate types. Correspondence analysis (CA) based ordination methods is used for structural and compositional comparison in order to address the question of the extent to which woody vegetation recovery and succession are similar between the two disturbance types. In addition, canonical CA is used as a general linear model strategy to examine unique and covariant influences on forest composition. The postlogged stand dataset had a much lower representation of conifer-dominated stands than the postfire dataset and a far greater proportion of stands dominated by poplars. Detrended and canonical CA on all 381 stands indicated a primary influence on stand composition due to site factors, but disturbance type and intensity, i.e. wildfi.
Pengaruh Posisi Pronasi Terhadap Status Hemodinamik Anak Yang Menggunakan Ventilasi Mekanik Di Ruang Pediatric Intensive Care Unit (Picu) Rsab Harapan Kita Jakarta

One of therapeutic interventions to children receiving mechanical ventilation is pronation position that is aimed to improve the distribution of ventilation and reduce shunt intrapulmonary. The purpose of this study is to determine the effect of pronation position on the hemodynamic status of pediatric in the Pediatric Intensive Care Unit with 15 sample. The study used quasi experiment one-group pretest-posttest design. Measurement of hemodynamic status used the observation sheet to assess the respiratory rate, oxygen saturation, blood pressure, mean arterial pressure, and heart rate. The results of bivariate analysis were significant differences between oxygen saturation before and after the intervention with p value of 0.004 (p < 0.005, α: 0.05). In conclusion, pronation position effectively increases oxygen saturation.
A new nomenclatural combination in Malva L. (Malvaceae)

SUMMARY: The name Lavatera  columbretensis, recently proposed for a hybrid growing in the Columbretes Archipelago (Castellon, E of Spain), is transferred to Malva. Additional data on nomenclature of other related taxa of ‘L. sect. Anthema’ and ‘L. sect. Axolopha’, are also reported. Key words: Lavatera, Malva, hybrids, Mediterranean islands, Spain. RESUMEN: Se transfiere al genero Malva el nombre Lavatera  columbretensis, recientemente descrito para un hibrido encontrado en el archipielago de las Columbretes (Castellon). Ademas, se presentan datos complementarios sobre la nomenclatura de otros taxones de ‘L. sect. Anthema’ y ‘L. sect. Axolopha’, con el relacionados. Palabras clave: Lavatera, Malva, hibridos, islas mediterraneas, Espana.
Isotopes and new norms: Investigating the emergence of early modern U.K. breastfeeding practices at St. Nicholas Kirk, Aberdeen

In this study, we aim to extend the chronological, geographical, and societal scope of previous bioarchaeological research on infant diet and age at weaning in Britain in the past through the analysis of the large medieval and post-medieval skeletal assemblage from St. Nicholas Kirk, Aberdeen, Scotland. Stable carbon and nitrogen isotope data were obtained from rib collagen from 67 sub-adults across the two phases and were compared with mean adult female dietary isotope values. Nitrogen isotope data were modelled using the R Package WARN, along with previously published data sets, to provide quantitative age estimates for the commencement and completion of weaning at St. Nicholas Kirk and other medieval and post-medieval sites. Data from Phase A (12th? 15th century AD) suggest that breastfeeding may have continued up to and beyond the age of 2Â years, likely in combination with other foods. This complements previously published data from urban and rural medieval contexts in England, highlighting similarities in infant feeding practices across very different contemporary populations. Data from post-medieval Phase B at St. Nicholas Kirk (15th? 18th century AD) give new insights into early modern period breastfeeding and weaning practices, indicating that weaning commenced soon after birth and was completed relatively early (within a year). These data bridge the gap between previously published studies on medieval and late 18th- to 19th-century populations from the British Isles and suggest that trends observed at later urban sites may be rooted in preceding centuries, although the underlying reasons for this change are difficult to elucidate. Contributing factors may include the social and religious changes that occurred in the post-reformation period, such as the decrease in the use of wet nurses, changes in the availability and acceptability of artificial feeding, increased urbanism, and even changes in the socio-economic status of those interred in the Kirk.
A laboratory behavioral assessment on predatory potential of the green lacewing Mallada basalis Walker (Neuroptera: Chrysopidae) on two species of papaya pest mites, Tetranychus kanzawai Kishida and Panonychus citri (McGregor) (Acari: Tetranychidae)

Tetranychus kanzawai Kishida and Panonychus citri (McGregor) are the two major arachnid pests of screenhouse-cultivated papayas in Taiwan. Control of these mites has become more difficult because both pests have become resistant to most registered miticides. This laboratory study investigated the feeding behaviors, predatory potential, and prey preference of a domesticated line of Mallada basalis Walker, a commonlyoccurring chrysopid in Taiwan, to both of these pest mites. A laboratory assessment on control efficacies of different predator:prey release ratios to single and mixed-pest species was also conducted. Behavioral study showed that all larval stages of M. basalis exhibited a high rate of acceptance of all life stages of both T. kanzawai and P. citri. Second and third instar predators foraged actively during most of the 2-h tests. Numbers and rates of prey consumption were measured for each instar of predator and prey. Results showed that consumption increased and prey handling time decreased as predator life stage advanced, and prey stage decreased. Mallada basalis exhibited both a shorter handling time and corresponding higher consumption rate on P. citri compared with T. kanzawai. Handling time and consumption rate also were positively affected by increasing prey density. Mallada basalis did not exhibit notable species or life stage preferences, and prior feeding experience on one mite species did not affect subsequent prey choice between the two mites. Lacewings significantly reduced T. kanzawai and P. citri populations at a predator:prey ratio of 1:30 and this improved at ratios of 1:15 and 1:10. Control of T. kanzawai was slightly better than P. citri when the mites occurred singly and together. Consumption by M. basalis increased with temperature up to 30°C. I conclude that M. basalis has high potential for augmentative biological control of papaya mites. Further field investigations are needed for making final recommendations. A LABORATORY BEHAVIORAL ASSESSMENT ON PREDATORY POTENTIAL OF THE GREEN LACEWING MALLADA BASALIS WALKER (NEUROPTERA: CHRYSOPIDAE) ON TWO SPECIES OF PAPAYA PEST MITES, TETRANYCHUS KANZAWAI KISHIDA AND PANONYCHUS CITRI (MCGREGOR) (ACARI: TETRANYCHIDAE)
TGFbeta-Dependent ROS Regulates a Local Endocrine Communication Network Between Stromal and Epithelial Cells in the Prostate

The development of prostate cancer (PCa) can be considered a co-evolution of both the epithelial and stromal cells; indeed, the latter develop their own unique gene signature during cancer progression that has potential predictive value in determining a patient’s outcome. Cancer-associated “reactive” stroma is characterized by heterogeneity in Transforming Growth Factor β (TGFβ) signaling, transdifferentiation into a myofibroblast phenotype by stromal fibroblasts, and an increased production of reactive oxygen species (ROS). In this study, we sought to examine the basis for PCa cell response to reactive prostate stromal cells (i.e. myofibroblasts) in vitro. Specifically, we have shown that human prostate derived fibroblastic (i.e. PS30) and myofibroblastic (i.e. WPMY-1) cell lines and primary stromal cells have the capacity to inhibit DU145 PCa cell motility in co-culture through the production of a precursor ligand for estrogen receptor β (ERβ). Activating the ERβ pathway in adjacent DU145 cells leads to induction of the cell adhesion molecule E-cadherin and a subsequent reduction in cell motility. However, an increased responsiveness to TGF-β1 in WPMY-1 cells triggers induction of COX-2 expression and elevated ROS production, which ultimately raises extracellular H2O2. H2O2 derived from WPMY-1 cells acts in a paracrine manner to decrease the recruitment of ERβ to the E-cadherin promoter in co-cultured DU145 cells, as revealed by chromatin immunoprecipitation assays. shRNA knockdown of COX-2 in WPMY-1 cells abolishes the TGF-β1-induced ROS production and restores the inhibitory effects of myofibroblasts on DU145 cell motility in co-culture. Therefore, despite their “reactive” stroma phenotype, limiting the TGFβ-driven ROS production in WPMY-1 cells restores their inherent capacity to limit tumor progression through a local endocrine network targeting ERβ in adjacent PCa cells. Our results imply that controlling the redox status of the local milieu may offer a route for utilizing inherent regulatory mechanisms to limit cancer cell motility, ultimately acting to reduce its spread and dissemination.
Oyster resources of India

Of the 8 species of Crassostrea listed by Awati and Rai (1931) only C. madrasensis (Preston), C. gryphoides (Newton & Smith), C. discoidea (Gould) and C. cucuU lata are known to be economically and commercially important so far as India is concerned. Following Stenzel (1971) who recognised Saccostrea as one of the eight genera of living oysters the tuberculated species, Crassostrea cucuUata is now designated as Saccostrea cucullata (Born). It has now been reported by Rao (personal communication) that it is C. rivularis (Gould) that occurs all along the Gujarat Coast and in some regions of Maharashtra coast. Judging from the commonness and distributional abundance of these 4 species under the two g snera found in India it can be reasonably stated that C. madrasensis is the native oyster of India and C gryphoides and C. rivularis may be designated as west coast oysters for the purpose of convenience.
Long-term response of China hybrid tea (Camellia sinensis) to nitrogen, phosphorus and potassium in Himachal Pradesh

An experiment was conducred during 1975-90 to study long-term response of China hybrid tea [Camellia sinensis (L.) O. Kuntze] to N, P and K. A 120-year-old China hybrid tea section was fertilized with N @ 0, 90 and 180 kg/ha (N 0 , N 90 and N 180 ); P@ 0, 39 and 78 kg/ha (P 0 , P 39 and P 78 ); and K @ 0, 33 and 66 kg/ha (K 0 , K 33 and K 66 ). On the basis of 16-year average an increase in yield of 74.4, 32.8 and 40.5% was recorded with N 90 , P 39 and K 33 respectively. Significant responses were observed when N and P were applied with K. The fertilizer combinations of N 90 K 66 and P 78 K 66 increased the yield by 108.1 and 39.9% respectively compared with the control. The maximum increase in yield (155.1 % compared with the control) was recorded with combination of N 180 P 78 K 33 .
Synthesis and characterization of carboxymethyl cellulose from palm kernel cake

Carboxymethyl cellulose (CMC) is one of the important cellulose derivativ es in industries, which is widely used as anti-caking agent, emulsifier , stabilizer, dispersing agent, thickener, and gelling agent. The main raw material of cellulose derivative is cellulose from wood and cotton linter. However, deforestation and acceleration of green house effects gradually grown interest on agriculture products and by-products as alternative cellulose resources. Palm kernel cake (P KC) is an abundant agriculture by-product which consists of 20-30% cellulose. It is significantly considered as one of the alternative secondary resource for cellulose. In this work, cellulose is extracted and recovered from palm kernel cake and then converted to CMC. Acidified sodium chlorite process was applied to extract th e cellulose from PKC. Carboxymethyl cellulose was then prepared using cellulose from acidified sodium chlorite process. 65.66% of cellulose was produced from PKC using acidified sodium chlorite process. By using the optimum carboxymethylation condition for pure cellulose, the result showed that degree of substitution (DS), pr oduct yield and viscosity for CMC were 0.67, 1.6475g/g and 66.6cP respectively.
DISTRIBUCION SUPERFICIAL DE FOSFATOS Y SILICATOS EN BAHIA SAN QUINTIN, B.C.

The phosphate and silicc e concentration in San Quintin Bay increases, in general, from the moct1-, tc. the interiors of the Bay. It reaches very high values of more than 4 M for phosphate, and more than 38rM for silicate. ff oth, phosphate and silicate, at the lth, are higher durina summer than winter, because 51 http://dx.doi. org/10.7773/cm.v3i1. 293
Altruistic behaviour in Dictyostelium discoideum explained on the basis of individual selection

It is often argued that natural selection acting at the level of the individual may not be sufficient to explain the evolution of altruism. We suggest that before accepting such a point of view in any specific instance, the parsimonious course would be to examine all possible ways in which individual-level selection might act and rule out its sufficiency only when the postulated means for its action are either inherently improbable or experimentally disproven. As an illustration we propose an evolutionary model, based on the individual cell as the unit of selection, for the maintenance of 'altruistic' behaviour by pre-stalk cells in the social amoeba Dictyostelium discoideum.
The Role of Trim58 in Erythropoiesis

Red blood cells (erythrocytes) deliver oxygen to all tissues of the body. Defects in red blood cell production (erythropoiesis) can cause disease. Mammalian erythropoiesis culminates in enucleation, an incompletely understood process that entails the physical separation of the nucleus and cytoplasm. The work in this thesis investigated the role of a previously uncharacterized protein named Trim58 in erythropoiesis. Human genetic studies suggested that TRIM58 played an important role in erythroid development. In humans and mice, Trim58 expression was found to be restricted to red blood cell precursors during late stage maturation. In fact, murine Trim58 was upregulated just prior to enucleation. Using short hairpin RNAs, Trim58 expression was inhibited in cultured murine erythroblasts. Through a variety of analyses, it was demonstrated that Trim58 is dispensable for early erythroid maturation. However, Trim58 knockdown impaired movement of the nucleus, thereby inhibiting enucleation. Trim58 is a member of the tripartite motif-containing family of proteins, many of which function as E3 ubiquitin ligases that can facilitate protein degradation. Protein interaction studies demonstrated that Trim58 bound directly to the molecular motor protein complex dynein. Consistent with its putative role as an E3 ubiquitin ligase, ectopic Trim58 expression in HeLa cells caused dynein degradation in a proteasomedependent fashion. Furthermore, dynein loss and efficient enucleation were coincident and dependent upon Trim58 induction during erythroid culture maturation. Dynein mediates unidirectional nuclear movement toward the microtubule organizing center. Erythroid enucleation requires nuclear movement in the opposite direction. Hence, Trim58-mediated dynein degradation may be responsible for nuclear movement during enucleation. Our findings identify Trim58 as the first erythroid-specific protein that regulates this process. More broadly, regulated proteolysis represents a previously unappreciated mode of regulation for dynein, which is critical for many cellular processes. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Cell & Molecular Biology First Advisor Mitchell J. Weiss