Miracle-dz/UniFAR-FTUs huggingface dataset:
Medicare part D and the nursing home setting.

PURPOSE The purpose of this article is to explore how the introduction of Medicare Part D is changing the operations of long-term-care pharmacies (LTCPs) and nursing homes, as well as implications of those changes for nursing home residents. DESIGN AND METHODS We reviewed existing sources of information and interviewed stakeholders across various perspectives. We conducted 31 semistructured telephone interviews with key stakeholders between November 2006 and January 2007. RESULTS Part D represents a substantial departure from how prescription drugs were previously financed and administered in nursing homes, and nursing home providers and LTCPs have struggled in adapting to some of these changes. Part D increased the variation around formularies and drug management processes for residents at the facility level, creating additional burden on clinical and pharmacy staff and introducing a tension between facilities' need to dispense medications quickly and assuring of coverage for those drugs. Nursing home and LTCP stakeholders perceive wide variation across Part D plans in their ability to meet the needs of nursing home residents. IMPLICATIONS Although LTCPs, nursing homes and their clinicians, and Part D plans will gain experience with the benefit in the nursing home setting over time, stakeholders we interviewed identified a range of longer term issues and questions that merit attention as the benefit proceeds.
Deep Learning in Multiple Multistep Time Series Prediction

The project aims to research on combining deep learning specifically Long-Short Memory (LSTM) and basic statistics in multiple multistep time series prediction. LSTM can dive into all the pages and learn the general trends of variation in a large scope, while the well selected medians for each page can keep the special seasonality of different pages so that the future trend will not fluctuate too much from the reality. A recent Kaggle competition on 145K Web Traffic Time Series Forecasting [1] is used to thoroughly illustrate and test this idea.
The Creation of New Knowledge by Information Retrieval and Classification

Knowledge can be created by drawing inferences from what is already known. Often some of the requisite information is lacking and has to be gathered by whatever research techniques are appropriate, e.g. experiments, surveys etc. Even if the information has all been published already, unless it is retrieved no inferences will be drawn from it and consequently there will exist some knowledge that is implicit in the literature and yet is not known by anyone. This ‘undiscovered public knowledge’, as it is termed by Swanson, may exist in the following forms: (i) a hidden refutation or qualification of a hypothesis; (ii) an undrawn conclusion from two or more premises; (iii) the cumulative evidence of weak, independent tests; (iv) solutions to analogous problems; (v) hidden correlations between factors. Methods of classification may also play a direct role in the creation of original knowledge. Novel solutions to problems may be discovered by generating different combinations of the basic features of the solutions, as is done in morphological analysis. Alternatively a natural classification may identify gaps in existing knowledge. This paper reviews previous work on producing knowledge by information retrieval or classification and describes techniques by which hidden knowledge may be retrieved, e.g. serendipity in browsing, use of appropriate search strategies and, possibly in the future, methods based on Farradane's relational indexing or artificial intelligence.
A Measurement-Based Prioritization Scheme for Handovers in Mobile Cellular Networks

A method of improving the quality of service in mobile cellular systems based on prioritization of handover requests is presented. The objective is to improve perceived quality of cellular service by minimizing both the probability of forced termination of ongoing calls due to handover failures and the degradation in spectrum utilization. A model based on a multiple-priority nonpreemptive queuing discipline is developed. New calls are blocked if all channels are occupied. Handover requests are queued such that as soon as a channel is available, it is offered to the mobile subscriber with the measurement results closest to the minimum acceptable power level for communication. Service rate is given by channel occupancy time distribution and is assumed to be exponential. The performance of a cellular system employing the proposed handover policy is evaluated analytically and by simulation, and results are compared to those obtained when the cellular system employs nonprioritized call handling and first-in/first-out queuing discipline. This provides lower probability of forced termination and less call blocking, less reduction in traffic, and less delay. >
Detecting Online Rumors with Sentiment Analysis

: [ Objective ] This paper aims to identify rumors automatically with the help of sentiment analysis. [ Methods ] First, we chose high-quality and low-quality information sources. Then, we calculated the sentiment value and difference between the information from different sources. Based on the assumption that the information from high-quality source was more reliable, information from low-quality channels could be listed as rumor if the sentiment difference between them exceeded the pre-set threshold. [ Results ] We applied the proposed method to information on food and health as well as health and medical issues, and then successfully identified twenty-three rumors from thirty suspected cases. The accuracy rate of rumor detection was 76.67%, the F-value was 83.34%, the recall and precision was 71.42% and 100%, respectively. For non-rumor message, the F-value, recall, and precision were 72.73%, 100% and 57.14%. [ Limitations ] We did not extract the data automatically from different sources and the sample size was relatively small. [ Conclusions ] Sentiment analysis could help us identify rumors effectively.
Small Group Meeting on Non-linear Dynamics in Work and Organizational Psychology : To Non-linear Modelling ... and Beyond

Daily hassles are a constant in daily life at work. It is shown that these kind of daily events affect diverse outcomes (e.g. well-being). In this study, we aim explore whether the relationships between daily hassles, mindfulness, work engagement and creativity are linear or nonlinear ones. To achieve that, we conducted a diary study through five working consecutive days within a sample of workers. So far, we have 45 participants (N = 45*5 = 225), however we are still gathering data. This study is intended to use non-linear analyses, once it is proved that nonlinear models should be applied to the study of work and organizational psychology. Moreover, we believe, that this study will provide new theoretical elements for models that explain employees work engagement and creativity at work. Additionally, the use of nonlinear analyses will give insights into the use of these kind of statistical methods within organizational behavior. Thus, results will arise implications for employee health and organizational success.
Functions of reminiscence and the psychological well-being of young-old and older adults over time

Existing cross-sectional research demonstrates an association between reminiscence functions and well-being in later life. The results of this study replicate and extend previous findings in separate participant samples above and below 70 years of age. Findings suggest a link between reminiscence functions and psychological well-being, and indirectly between reminiscence and well-being 16 months thereafter. Invariance analyses reveal few differences in association between reminiscence and well-being when young-old (n = 196) and older adults (n = 215) are compared. These findings suggest a direct positive association between self-positive reminiscence functions (identity, death preparation, and problem-solving) and a direct negative association between self-negative functions (boredom reduction, bitterness revival, and intimacy maintenance) and psychological well-being (life satisfaction, depressive, and anxiety symptoms). In contrast, prosocial reminiscence functions (conversation, teach/inform others) appear to have an indirect association with well-being (i.e., via self-positive and self-negative functions). These findings are discussed relative to evolving theory and research linking cognition and health.
Comparison of the effectiveness and safety of transscleral cyclophotocoagulation and endoscopic cyclophotocoagulation in pediatric glaucoma.

PURPOSE Among the options for surgical management of pediatric glaucoma, destruction of the ciliary body reduces aqueous production and, consequently, intraocular pressure (IOP). Compared to more invasive filtering and shunt procedures, cyclodestruction is an attractive option for control of IOP in pediatric glaucomas. METHODS The relative reduction in IOP, duration of effect, and comparable safety and efficacy of transscleral cyclophotocoagulation (TSCP) and endoscopic cyclophotocoagulation (ECP) in pediatric patients with glaucoma was studied in this retrospective chart review. RESULTS A reduction in IOP of 28.6% and 33.2% with TSCP and ECP, respectively, was found. Eyes treated with ECP underwent an average of 3.24 cyclodestructive procedures; eyes treated with TSCP underwent an average of 2.29 cyclodestructive treatments. These differences were not statistically significant. A final success rate of 67.6% after TSCP and 62% after ECP failed to significantly differ between the two groups. Consequently, two-thirds of the patients were able to avoid penetrating surgery and the associated risks after one or more cyclodestructive procedures. CONCLUSIONS TSCP and ECP are safe, effective, and comparable treatments for pediatric glaucomas. The results suggest that TSCP and ECP may be considered first-line therapy to achieve control of IOP in all forms of pediatric glaucoma. [J Pediatr Ophthalmol Strabismus 2014;51(2):120-127. ].
Managing social risks of non-standard employment in Europe

This study analyses the extent, structure and development of non- standard employment (NSE) in Europe as well as its consequences on economic performance and social inclusion. In this study, we follow the definition of NSE used by the ILO, which includes part-time work, temporary work (fixed or project based contracts, casual labour, minijobs or even zero-hour contracts), triangular employment relationships through temporary agencies or subcontracting companies, but also include self-employment. Self-employment is a still a relatively small employment category in Europe when compared with wage employment, but it has nonetheless risen recently. Its rise should be understood within the context of the diversification of work, in particular own-account work.
Characterising social media users by gender and place of residence

enero, lugar de residencia, usuarios, an alisis de me- dios sociales Abstract: Characterising users through demographic attributes is a necessary step before conducting opinion surveys from information published by such users in social media. In this paper, we describe, compare and evaluate dierent techniques for the identication of the attributes \gender" and \place of residence" by mining the metadata associated to the users, the content published and shared by themselves, and their friendship networks. The results obtained show that the social network is a valuable source of information for obtaining the sociodemographic attributes of single users.
Aerosolized antibiotics in cystic fibrosis: an update

Inhaled antibiotic therapy, targeting Pseudomonas aeruginosa, is a fundamental component of cystic fibrosis (CF) management. Tobramycin inhalation solution (TIS) was approved in the United States (US) in 1998. Subsequent research efforts focused on developing products with a reduced treatment time burden. Aztreonam for inhalation solution (AZLI), administered via a more efficient nebulizer than TIS, was approved in the US in 2010. Dry powder for inhalation (DPI) formulations provide alternatives to nebulized therapy: tobramycin powder for inhalation (also known as TIP™) was approved in the US in 2013, and colistimethate sodium DPI received European approval in 2012. Other aerosolized antibiotics and regimens combining inhaled antibiotics are in development. Inhaled antibiotic rotation (e.g., TIS alternating with AZLI) is an important concept being actively tested in CF.
Globalization and cultural differences in financial reporting

Quality of accounting information determines the quality of information used by financial markets and it is therefore value relevant. Recent development in the area of application of IFRS and growing number of countries, that adopt IFRS standards in their national environment as a vital alternative to national GAAPs reveals that the whole process of harmonisation of accounting and reporting faces a number of issues worth further investigation. The issue of cultural differences and their impact on implementation of international reporting standards has been analysed in scientific literature by both accounting scholars and practitioners. After the compulsory adoption of IFRS by publically listed firms in the EU in 2005, there have emerged many research studies on centripetal and centrifugal forces in financial reporting in various national environments. In our contribution we use a qualitative holistic approach to characterize the influence of cultural factors on adoption of international reporting standards. We attempt to create a coherent roadmap of different layers influencing the dynamics of accepting the common financial rules.
Current Issues and Situation of Producer Responsibility in Waste Management in Indonesia

Producer responsibility for wastes has been encouraged in Indonesia since 2008. The Ministry of Environment of the Republic of Indonesia also promoted the reduce, reuse, and recycle (3R) concept using the community-based approach of waste banks integrated with the extended producer responsibility (EPR) concept. However, related research and implementation are still limited. This study aims to identify the challenges of fulfilling producer responsibility in waste management and determine whether the integration concept could generate outcomes expected from the EPR concept. A semi-structured interview survey of several stakeholders from the government, industrial, and waste management sectors was conducted and the data generated was used to simulate an integration scheme using a system dynamics approach. Secondary data and information from Bandung municipality were used as input for the simulation. The interview survey found that the concerns and issues of fulfilling producer responsibility in waste management include lack of awareness, unavailability of clear guidelines, and the limited capacity of the current recycling sector. The results of the simulation suggested that if the integration scheme is applied, each business entity might bear the responsibility of IDR 29.4 million per year and 14.7 tons of waste per year for the scope of four sectors and IDR 34.1 million per year and 17 tons of waste per year for the scope of two sectors.
Clinical Interpretation of Reticulocyte Hemoglobin Content, RET-Y, in Chronic Hemodialysis Patients

Background: Iron deficiency is the most common factor associated with erythropoietin (EPO) hyporesponsiveness. Current iron indices are inadequate to demonstrate the status or utility of iron in erythropoiesis. The aims of this study are to investigate the value of the reticulocyte hemoglobin content, RET-Y, in hemodialysis (HD) patients and compare the levels with conventional iron indices. Methods: HD patients (n = 289) were divided into 4 groups according to serum ferritin (cutoff value 100 ng/ml) and transferrin saturation (TSAT, cutoff value 20%). The RET-Y value, hemogram and biochemical data were determined and compared between groups. Factors associated with RET-Y were examined. Results: The mean RET-Y value was 1,716 ± 125 AU. Patients with absolute iron deficiency had lower RET-Y levels and mean corpuscular volume (MCV). Patients with functional iron deficiency had a lower reticulocyte production index and serum albumin levels. MCV, mean corpuscular hemoglobin concentration (MCHC) and albumin were independently correlated with the RET-Y level (all p < 0.001). EPO-independent patients had low iron indices and low RET-Y levels, but a higher reticulocyte production index and albumin levels were noted. Conclusion: RET-Y levels in HD patients were close to that of the normal population. Low RET-Y levels were observed in patients with absolute iron deficiency and also in EPO-independent patients with low ferritin and low TSAT. There was a strong association between the serum albumin and RET-Y levels in chronic HD patients.
Distribution of the mRNAs encoding the thyrotropin‐releasing hormone (TRH) precursor and three TRH receptors in the brain and pituitary of Xenopus laevis: Effect of background color adaptation on TRH and TRH receptor gene expression

In amphibians, thyrotropin‐releasing hormone (TRH) is a potent stimulator of α‐melanotropin (α‐MSH) secretion, so TRH plays a major role in the neuroendocrine regulation of skin‐color adaptation. We have recently cloned a third type of TRH receptor in Xenopus laevis (xTRHR3) that has not yet been characterized in any other vertebrate species. In the present study, we have examined the distribution of the mRNAs encoding proTRH and the three receptor subtypes (xTRHR1, xTRHR2, and xTRHR3) in the frog CNS and pituitary, and we have investigated the effect of background color adaptation on the expression of these mRNAs. A good correlation was generally observed between the expression patterns of proTRH and xTRHR mRNAs. xTRHRs, including the novel receptor subtype xTRHR3, were widely expressed in the telencephalon and diencephalon, where two or even three xTRHR mRNAs were often simultaneously observed within the same brain structures. In the pituitary, xTRHR2 was expressed selectively in the distal lobe, and xTRHR3 was found exclusively in the intermediate lobe. Adaptation of frog skin to background illumination had no effect on the expression of proTRH and xTRHRs in the brain. In contrast, adaptation of the animals to a white background provoked an 18‐fold increase in xTRHR3 mRNA concentration in the intermediate lobe of the pituitary. These data demonstrate that, in amphibians, the effect of TRH on α‐MSH secretion is mediated through the novel receptor subtype xTRHR3. J. Comp. Neurol. 477:11–28, 2004. © 2004 Wiley‐Liss, Inc.
Multi-band combined LNA and mixer

In this paper we investigate the performance of the multi-band low noise amplifier (LNA) based on the concept of using multiple cascode transistors for band selection; thus, avoiding switches in the signal path. We also show that this circuit can perform mixing of two signal bands with two different local oscillator frequencies, which provides great flexibility in the design of dual-band RF front-ends. The operation of both as LNA and as combined LNA/mixer is demonstrated by simulation.
Age interval and gender prediction using PARAFAC2 and SVMs based on visual and aural features

Parallel factor analysis 2 (PARAFAC2) is employed to reduce the dimensions of visual and aural features and provide ranking vectors. Subsequently, score level fusion is performed by applying a support vector machine (SVM) classifier to the ranking vectors derived by PARAFAC2 to make gender and age interval predictions. The aforementioned procedure is applied to the Trinity College Dublin Speaker Ageing database, which is supplemented with face images of the speakers and two single-modality benchmark datasets. Experimental results demonstrate the advantage of using combined aural and visual features for both prediction tasks.
Is oral spelling recognition dependent on reading or spelling systems? dissociative evidence from two single case studies

Recognition of orally spelt words is an unusual task, not commonly encountered in everyday life, but it can be surprising well preserved in patients with brain damage. There is, however, considerable debate over the cognitive abilities that are required to successfully perform this task. The main controversy has centred on whether oral spelling recognition is parasitic on the processes normally involved in spelling aloud or in reading. We describe a patient (FL) who showed a similar pattern of performance on reading and oral spelling recognition and was better at both tasks relative to spelling. We describe a second patient (FK) who was good at reading and reasonable at spelling but poor at reverse spelling. The patient data are not consistent with either of the following hypotheses: that oral spelling recognition is dependent either on a reading system that is functionally separate from a spelling system, or on a spelling system that is functionally separate from reading. We propose that the findings can, however, be accommodated by a model in which spelling and reading are not functionally independent systems, but share important cognitive components such as a graphemic buffer.
Using Porterian activity analysis to understand organizational capabilities

The article argues that organizational capabilities are comprised of two fundamental components: resources and activities. The starting point of the argument is that resources are best conceptualized by Barney’s and others’ research on the resource-based view, while activities are best conceptualized by Porter’s writings on the activity-based view. Porterian activity analysis is becoming more accepted in the strategy literature, but no strategy scholar has explicitly used Porter’s activities, and particularly his concept of drivers, to understand and analyze organizational capabilities. Introducing Porterian activities into the discussion of capabilities improves strategy scholars’ understanding of the bases of capability heterogeneity, offers academics future directions for research, and provides managers with guidance to enhance their organizations’ capabilities.
hTERT-targeted E. coli purine nucleoside phosphorylase gene/6-methylpurine deoxyribose therapy for pancreatic cancer.

BACKGROUND Pancreatic cancer is one of the most common tumors and has a 5-year survival for all stages of less than 5%. Most patients with pancreatic cancer are diagnosed at an advanced stage and therefore are not candidates for surgical resection. In recent years, investigation into alternative treatment strategies for this aggressive disease has led to advances in the field of gene therapy for pancreatic cancer. E. coli purine nucleoside phosphorylase/6-methylpurine deoxyribose (ePNP/MePdR) is a suicide gene/prodrug system where PNP enzyme cleaves nontoxic MePdR into cytotoxic membrane-permeable compounds 6-methylpurine (MeP) with high bystander activity. hTERT is expressed in cell lines and tissues for telomerase activity. In this study we examined the efficacy of ePNP under the control of hTERT promoter sequences and assessed the selective killing effects of the ePNP/prodrug MePdR system on pancreatic tumors. METHODS Recombinant pET-PNP was established. The protein of E. coli PNPase was expressed and an antibody to E. coli PNPase was prepared. Transcriptional activities of hTERT promoter sequences were analyzed using a luciferase reporter gene. A recombinant phTERT-ePNP vector was constructed. The ePNP/MePdR system affects SW1990 human pancreatic cancer cell lines in vitro. RESULTS The hTERT promoter had high transcriptional activity and conferred specificity on cancer cell lines. The antibody to E. coli PNPase was demonstrated to be specific for the ePNP protein. The MePdR treatment induced a high in vitro cytotoxicity on the sole hTERT-ePNP-producing cell lines and affected SW1990 cells in a dose-dependent manner. CONCLUSIONS The hTERT promoter control of the ePNP/MePdR system can provide a beneficial anti-tumor treatment in pancreatic cancer cell lines including a good bystander killing effect.