Miracle-dz/UniFAR-FTUs huggingface dataset:
H+-pyrophosphatase from Salicornia europaea enhances tolerance to low phosphate under salinity in Arabidopsis

ABSTRACT Increasing soil salinity threatens crop productivity worldwide. High soil salinity is usually accompanied by the low availability of many mineral nutrients. Here, we investigated the potential role that the H+- PPase could play in optimizing P use efficiency under salinity in plants. Transgenic Arabidopsis plants overexpressing either SeVP1 or SeVP2 from Salicornia europaea outperformed the wild-types under low phosphate (Pi) as well as low Pi plus salt conditions. Our results suggested that H+-PPase could increase external Pi acquisition through promoting root development and upregulating phosphate transporters, thus to protect plants from Pi limiting stress. This study provides a potential strategy for improving crop yields challenged by the co-occurrence of abiotic stresses.
In vivo Administration of TLR9 Agonist Reduces the Severity of Experimental Autoimmune Encephalomyelitis. The Role of Plasmacytoid Dendritic Cells and B Lymphocytes

In vivo Administration of TLR9 Agonist Reduces the Severity of Experimental Autoimmune Encephalomyelitis. The Role of Plasmacytoid Dendritic Cells and B Lymphocytes Ana Leda F. Longhini, Mariana P. A. Santos, Fernando Pradella, Adriel S. Moraes, Alliny C. Dionete, Marilia D. Andrade, Paula G. Russini, Elaine C. Oliveira, Rosemeire O. F. dePaula, Guilherme A. D. Morais, Evelise S. M. Fonseca, Alessandro S. Farias & Leonilda M. B. Santos
Novel SGCE gene mutation in a Korean patient with myoclonus–dystonia with unique phenotype mimicking Moya–Moya disease

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EFFECT OF AN EXPERIMENTAL BOTTLENECK ON MORPHOLOGICAL INTEGRATION IN THE HOUSEFLY

Three measures of multivariate integration were derived from both additive genetic covariance and correlation matrices estimated from parent‐offspring covariances to investigate the effect of bottlenecks of different sizes on genetic integration of morphological traits in the housefly, Musca domestica L. Bottleneck lines were initiated with one, four, or 16 pairs of flies sampled from a natural outbred (control) population. Bottlenecks of intermediate size significantly increased the average genetic correlation among traits, resulting in nearly isomorphic variation among all traits in these lines. Single‐pair bottlenecks significantly disrupted the trait interrelationships, and the suites of traits identified by principal components of the additive genetic correlation and covariance matrices for the control population were no longer evident in these bottleneck lines. The alteration of the genetic relationships among traits as a result of a bottleneck suggests that nonadditive components of genetic variation affecting these traits were present in the control line. We discuss the implications of nonadditive gene action, particularly epistasis, for speciation via bottlenecks.
Comprehensive review on herbal medicine for energy intake suppression

The obesity drug development is present not a bright and successful story. So far, drugs reported to be effective, either from synthetic or natural sources, mostly stimulated controversy because of serious adverse effects, which ended with stopping clinical trials or even withdrawal from the market. However, obesity and its comorbidities have become rapidly a major problem in both developed and developing countries. This has encouraged pharmaceutical companies and academia to keep on struggling on developing novel effective but safe obesity drugs, and on characterizing novel obesity drug targets. From existing scientific work on obesity drug discovery and commercial slimming preparations, compounds originating from nature, especially from plants, seem to be the first choice. Traditional belief that herbal medicine is safer than synthetic ones is one of the classical arguments, although scientifically this is not always true (e.g. ban on Ephedra). But in general, it has been widely acknowledged that a plant compound, with its unique scaffolds and rich diversity is an unlimited source of novel lead compounds. This paper aims to summarize all works focused on screening plant materials by targeting important pathways related to energy intake regulation, either by in vivo or in vitro experiments.
Literacia como fundamento da cidadania

Resumo A comunicacao que se apresenta pretende sublinhar a importância e actualidade das diversas literacias, base dos Direitos Humanos e fundamento de praticas de cidadania activa, ao nivel local e mundial. Apos uma abordagem do conceito de Literacia e da sua contextualizacao como direito previsto na Constituicao da Republica Portuguesa (1976), colocar-se-a em evidencia a problematica da literacia mediatica e estabelecer-se-a uma relacao com as competencias no uso e analise dos media, enfatizando-se o caso dos novos media. Relacionando-se Literacia e Educacao, esbocar-se-a um perfil de competencias orientadas para a formacao de cidadaos qualificados, dotados de competencias referenciadas em varios estudos, tanto de âmbito nacional como internacional. Reflecte-se sobre a literacia(s) no horizonte do binomio Educacao-Media, bem como sobre algumas experiencias e actividades pedagogicas que incluem, entre outras, estrategias de comunciacao-ludicidade que podem potenciar a info-inclusao de todos os cidadaos e de todos no mesmo pe de igualdade. A educacao e a escola serao focos em destaque. Ao preocupar-se por dotar os estudantes de competencias variadas, que os preparem para um eficiente desempenho profissional, a Escola nao pode esquecer que e sua missao promover e acompanhar o desenvolvimento, nao sao a nivel da especificidade tecnica de areas do conhecimento, mas tambem da formacao de uma atitude etica que se manifeste no saber-fazer-pensar-dizer-Ser, orientada por principios civicos, em que a igualdade, democracia, solidariedade, liberdade e cooperacao sejam efectivas.
Application of the Homotopy Perturbation Method to Nonlinear Heat Conduction and Fractional Van der Pol Damped Nonlinear Oscillator

In this paper, a powerful analytical method, called He’s homotopy perturbation method is applied to obtaining the approximate periodic solutions for some nonlinear differential equations in mathematical physics via Van der Pol damped non-linear oscillators and heat transfer. Illustrative examples reveal that this method is very effective and convenient for solving nonlinear differential equations. Comparison of the obtained results with those of the exact solution, reveals that homotopy perturbation method leads to accurate solutions.
A study on morphology of immature stages of Diplonevra peregrina (Wiedemann) (Diptera: Phoridae)

Morphology of all larval instars and puparium of Diplonevra peregrina, a most common phorid fly species indoors in China, is presented using scanning electron microscopy. The first instar larva was composed of 12 segments, each of segments 3–11 with six spicate tubercles situated dorsally, dorsolaterally, and laterally in transverse row. The dorsal tubercles were much longer than the laterals and dorsolaterals. Antennae and maxillary palp complex were visible. The caudal segment was margined by six long, stout tubercles covered by numerous long bristles at the base through the apex. Two slits could be seen at the posterior spiracle. Besides the presence of anterior spiracle, the tubercles of second instar became more stout than those of first instar and were covered by numerous long bristles from the base to top. The posterior spiracle contained four slits. Third larval instar was similar to second instar. The bubble membrane comprised of clusters of small spines presented at the segment 5 of third instar larvae. Puparia showed a retracted cephalic region and a pair of pupal respiratory horns on the dorsum. Microsc. Res. Tech. 2012. © 2012 Wiley Periodicals, Inc.
Control social y control de resultados: un balance de los argumentos y de la experiencia reciente

A medida que se acerca el fin del siglo, se torna cada vez más evidente que es necesario profundizar la democracia, por cuanto las instituciones diseñadas en los siglos XVIII y XIX, que dieron lugar a la Democracia Representativa, muestran demasiadas limitaciones para hacer frente a los desafíos que confrontan los gobiernos de las sociedades contemporáneas. La complejidad de las instituciones estatales y su impenetrabilidad, impiden el control de la actividad gubernamental por parte de la sociedad. El extrañamiento que muchas veces se establece entre Estado y sociedad hace que con frecuencia le dé la espalda al Estado, generando serios problemas de gobernabilidad. El crecimiento de las maquinarias gubernamentales, como consecuencia de la expansión de las funciones del Estado, ha hecho que muchas veces ellas se autonomicen por completo, ubicándose en situación de rebeldía ante los mecanismos del control democrático. El desequilibrio entre actores políticos y sociales perjudica crecientemente a los más vulnerables, impedidos de ejercer la presión correspondiente a los grupos de interés organizados. Los ciudadanos que no logran constituirse como actores resultan aún más debilitados. Por último, la intensificación del proceso de globalización hace que decisiones cruciales y dramáticas queden totalmente ajenas al control público. En medio de los procesos de Reforma del Estado, se abre el debate sobre las formas de su democratización. Tornar la información más accesible, buscar la transparencia, son algunas de las estrategias propuestas. Al mismo tiempo, se hace más evidente la necesidad de ampliar los mecanismos de accountability. En este ensayo se intentan desarrollar algunos de los argumentos expuestos por Bresser Pereira (1997) sobre las nuevas perspectivas de la relación entre Estado y sociedad, en especial a partir de la constitución de un sector público no estatal y de sus mecanismos de control; se hace un balance de la literatura que destaca las posibles virtudes del control social como instrumento para un nuevo pacto entre el Estado y sus ciudadanos, no sólo con los más organizados, sino también con los excluidos del juego político. Asimismo, se presenta un examen del control de resultados, que está siendo introducido por la administración gerencial como un mecanismo disponible para el control social. El examen de la experiencia reciente en este campo permite avanzar en lo que se refiere a las posibilidades y limitaciones actuales de esta alternativa.
Regional Differences in the Cellular Immune Response to Experimental Cutaneous or Visceral Infection withLeishmania donovani

ABSTRACT Infection with the protozoan Leishmania donovani can cause serious visceral disease or subclinical infection in humans. To better understand the pathogenesis of this dichotomy, we have investigated the host cellular immune response to cutaneous or visceral infection in a murine model. Mice infected in the skin developed no detectable visceral parasitism, whereas intravenous inoculation resulted in hepatosplenomegaly and an increasing visceral parasite burden. Spleen cells from mice with locally controlled cutaneous infection showed strong parasite-specific proliferative and gamma interferon (IFN-γ) responses, but spleen cells from systemically infected mice were unresponsive to parasite antigens. The in situ expression of IFN-γ, interleukin-4 (IL-4), IL-10, IL-12, and inducible nitric oxide synthase (iNOS) mRNAs was determined in the spleen, draining lymph node (LN), and cutaneous site of inoculation. There was considerably greater expression of IFN-γ and IL-12 p40 mRNAs in the LN draining a locally controlled cutaneous infection than in the spleen following systemic infection. Similarly, there was a high level of IFN-γ production by LN cells following subcutaneous infection but no IFN-γ production by spleen cells following systemic infection. Splenic IL-4 expression was transiently increased early after systemic infection, but splenic IL-10 transcripts increased throughout the course of visceral infection. IL-4 and IL-10 mRNAs were also increased in the LN following cutaneous infection. iNOS mRNA was detected earlier in the LN draining a cutaneous site of infection compared to the spleen following systemic challenge. Thus, locally controlled cutaneous infection was associated with antigen-specific spleen cell responsiveness and markedly increased levels of IFN-γ, IL-12, and iNOS mRNA in the draining LN. Progressive splenic parasitism was associated with an early IL-4 response, markedly increased IL-10 but minimal IL-12 expression, and delayed expression of iNOS.
The relation of aerobic fitness to stroop task performance in preadolescent children.

PURPOSE We investigated the relation between aerobic fitness and interference control--one component of executive control--in 74 children between 7 and 12 yr of age. METHOD Participants completed a paper-and-pencil version of the Stroop color-word task and the FITNESSGRAM, a valid and reliable test measuring different components of physical fitness (i.e., aerobic, muscle, and body composition). During each condition of the Stroop task (word, color, color-word), participants were instructed to read aloud as many items as possible in 45 s. Data were also collected on IQ and personal and health demographics to account for other factors influencing the relationship between fitness and executive function. RESULTS Older children and those with higher IQ responded to more items correctly during each of the three conditions. Greater aerobic fitness was also associated with better performance on each of the three Stroop conditions independently of the other variables. CONCLUSION These findings suggest that increased levels of fitness may be beneficial to cognition during preadolescent development.
Building New Understandings in Epilepsy: Maximizing Patient Outcomes Without Sacrificing Seizure Control

FIG. 1. Chronological introduction of antiepileptic drugs. ing AED choice fall into three categories (Table 1): issues relevant to individual patients, to seizure types and epilepsy syndromes, and to the pharmacology of the drugs themselves (3). Since seizures in many patients will be controlled by the first or second AED (4), chronic side effects of treatment need to be anticipated and avoided. A decade or more ago the clinical focus would have been almost entirely on seizure control, often at a substantial cost in terms of medication side effects (5). Of course, the goal of “no seizures” has not changed, but now we can afford to take a more holistic approach to management, given the much wider choice of available
The relationship between the levels of stress and the age and years of service of military firefighters from the fire rescue corps of the metropolitan area of the state of São Paulo.

PURPOSE To verify the relationship between stress indicators and the age and years of service of military firefighters from the fire rescue corps of the metropolitan area of the state of São Paulo. METHODS Forty military firefighters with the mean age of 37.9 ± 5.4 years, from the 1st, 2nd and 8th fire brigades of the metropolitan area of São Paulo participated in this study. All underwent clinical, physical and psychological evaluations to verify the relationship between the age and years of service with the variables of levels of stress (tension, depression, anger, vigor, fatigue, confusion and total stress) on workdays and on days off. RESULTS On workdays, the mean scores for tension, depression, fatigue and stress were overall higher compared to those on days off. The older the firefighter, the higher the levels of stress, depression, anger and total stress. The more years of service, the greater the depression and anger. CONCLUSIONS The levels of stress were high on workdays. Chronological age and years of service influenced the increase in the scores of stress.
Species differences in effect of gram-negative endotoxin on circulation.

Studies were made in 5 monkeys, 7 rabbits, and 33 cats of the effect of gram-negative endotoxin on aortic, pulmonary artery (PAP), and portal venous (PVP) pressures; and on changes in weight of a short segment of intestine. Studies of blood pooling were also made in 12 cats. The responses in these species were compared with those previously observed in the dog. Although variable degrees of hypotension developed at one time or another in all animals following injection of endotoxin, the early precipitous hypotension that characteristically occurs in the dog was observed only in the cat. However, in this species the dramatic fall in pressure could be ascribed to pulmonary vascular constriction and acute right ventricular hypertension and failure, and not to splanchnic pooling. PAP also became elevated in the monkey and the rabbit, but usually was of lesser magnitude and did not appear to explain the development of the relatively late hypotension that occurred in these species. The absence of significant inc.
Analysis of harmonic active power as criterion to assess the installation harmonic emission

In order to maintain good power quality, Distribution System Operators (DSOs) must keep harmonic voltage levels under limits specified in standards. These harmonic voltages result from non-linear equipment connected in installations, which inject harmonic currents into networks. To implement emission limits per installation, DSOs need to have an accurate and reliable indicator to assess the harmonic emission of an installation. In the literature, some authors propose to use the harmonic active power as this indicator. In this paper, a study is carried out on the use of the harmonic active power to locate harmonic sources on the network and assess the harmonic emission of an installation. It is demonstrated that harmonic active powers cannot be used when there are several harmonic sources connected to the network.
The state of political priority for safe motherhood in India

Approximately one‐quarter of all maternal deaths occur in India, far more than in any other nation on earth. Until 2005, maternal mortality reduction was not a priority in the country. In that year, the cause emerged on the national political agenda in a meaningful way for the first time. An unpredictable confluence of events concerning problem definition, policy alternative generation and politics led to this outcome. By 2005, evidence had accumulated that maternal mortality in India was stagnating and that existing initiatives were not addressing the problem effectively. Also in that year, national government officials and donors came to a consensus on a strategy to address the problem. In addition, a new government with social equity aims came to power in 2004, and in 2005, it began a national initiative to expand healthcare access to the poor in rural areas. The convergence of these developments pushed the issue on to the national agenda. This paper draws on public policy theory to analyse the Indian experience and to develop guidance for safe motherhood policy communities in other high maternal mortality countries seeking to make this cause a political priority.
Glypican-3: A Novel Diagnostic Marker for Hepatocellular Carcinoma and More

Glypican-3 (GPC3) is a heparan sulfate proteoglycan that plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both α-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. This article reviews the current information on the application of GPC3 immunostaining in surgical pathology and cytology.
The relationship between atrophy of the medial temporal area and daily activities in older adults with mild cognitive impairment

Background and aims: Many studies have suggested that social network, leisure activity, and physical activity can have protective effects against dementia and Alzheimer’s disease. However, previous studies have not examined the relationship between daily activities and brain atrophy in older adults. This study aimed to explore what kind of daily activities were associated with atrophy of the medial temporal area including the entorhinal cortex (MTA-ERC) in older adults. Methods: In total, 122 older adults (aged 65 and over) with subjective memory complaints or a Clinical Dementia Rating of 0. 5 underwent magnetic resonance imaging, and MTA-ERC atrophy was assessed by the voxel-based morphometry method. Based on magnetic resonance imaging data, the subjects were divided into atrophy and non-atrophy groups. Daily activities were assessed using a 20-item questionnaire (e.g., instrumental activities of daily living, social activities), and we compared activity participation between the groups. Results: The atrophy group (n=37) showed significantly lower participation in 4 out of 20 activity items (cleaning, intellectual activity, culture lessons, and using a personal computer) than the non-atrophy group (n=85). Summed scores of these 4 items (range from 0 to 4) were significantly associated with MTA-ERC atrophy even after adjustment for age, sex, education status, and Mini-Mental State Examination score. Conclusions: In conclusion, MTAERC atrophy was associated with cognitive activities or household-related activities requiring planning.