Miracle-dz/UniFAR-FTUs huggingface dataset:
A Mixed Model to Disentangle Variance and Serial Autocorrelation in Affective Instability Using Ecological Momentary Assessment Data

ABSTRACT Affective instability, the tendency to experience emotions that fluctuate frequently and intensively over time, is a core feature of several mental disorders including borderline personality disorder. Currently, affect is often measured with Ecological Momentary Assessment protocols, which yield the possibility to quantify the instability of affect over time. A number of linear mixed models are proposed to examine (diagnostic) group differences in affective instability. The models contribute to the existing literature by estimating simultaneously both the variance and serial dependency component of affective instability when observations are unequally spaced in time with the serial autocorrelation (or emotional inertia) declining as a function of the time interval between observations. In addition, the models can eliminate systematic trends, take between subject differences into account and test for (diagnostic) group differences in serial autocorrelation, short-term as well as long-term affective variability. The usefulness of the models is illustrated in a study on diagnostic group differences in affective instability in the domain of eating disorders. Limitations of the model are that they pertain to group (and not individual) differences and do not focus explicitly on circadian rhythms or cycles in affect.
Frequent mental distress (FMD) in Irish Travellers: Discrimination and bereavement negatively influence mental health in the All Ireland Traveller Health Study

Travellers are an indigenous minority group in Ireland, with poorer life expectancy and health status than the general population. Recent data have shown that Travellers are at increased risk of poor mental health and sequelae from same. We aimed to examine the associations between sociodemographic and lifestyle factors with poor mental health in Irish Travellers. A census survey of all Travellers was undertaken, with 8,492 enumerated families (80% response rate). A random subset of 1,796 adults completed an adult health survey. Traveller peer researchers employed a novel oral-visual computer-aided data collection tool. Frequent mental distress (FMD) was defined as 14 or more days of poor mental health in the preceding 1 month. Prevalence ratios for typical associates of FMD were estimated using a Poisson regression model, adjusted for age and sex. FMD was present in 11.9% of Traveller respondents, and prevalence increased with age. After age and sex adjustment, FMD was more prevalent in those whose quality of life was impaired by physical health, by those who were recently bereaved of a friend or family member, and by those who had greater experiences of discrimination. This study shows that Travellers experience discrimination and bereavement, which negatively influence their mental health. The findings have implications for the mental healthcare needs of indigenous ethnic minorities worldwide.
Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities

Background—Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies and linkage studies only partially explain the influence of genetics on KD susceptibility. Methods and Results—To search for additional functional genetic variation, we performed pathway and gene stability analysis on a genome-wide association study data set. Pathway analysis using European genome-wide association study data identified 100 significantly associated pathways (P<5×10−4). Gene stability selection identified 116 single nucleotide polymorphisms in 26 genes that were responsible for driving the pathway associations, and gene ontology analysis demonstrated enrichment for calcium transport (P=1.05×10−4). Three single nucleotide polymorphisms in solute carrier family 8, member 1 (SLC8A1), a sodium/calcium exchanger encoding NCX1, were validated in an independent Japanese genome-wide association study data set (meta-analysis P=0.0001). Patients homozygous for the A (risk) allele of rs13017968 had higher rates of coronary artery abnormalities (P=0.029). NCX1, the protein encoded by SLC8A1, was expressed in spindle-shaped and inflammatory cells in the aneurysm wall. Increased intracellular calcium mobilization was observed in B cell lines from healthy controls carrying the risk allele. Conclusions—Pathway-based association analysis followed by gene stability selection proved to be a valuable tool for identifying risk alleles in a rare disease with complex genetics. The role of SLC8A1 polymorphisms in altering calcium flux in cells that mediate coronary artery damage in KD suggests that this pathway may be a therapeutic target and supports the study of calcineurin inhibitors in acute KD.
Stable isotopes and the seasonality of the Oronsay middens

Research on six late Mesolithic shell middens on the small Hebridean island of Oronsay address questions of permanent and seasonal occupation. Stable isotope analysis of human bones shows marine resources providing the majority of protein, supporting year-round occupation of Oronsay. One individual, however, demonstrated a mixed diet of marine and terrestrial protein, suggesting seasonal visits and different patterns of site occupation.
A Conflict Resolution Strategy Selection Method (ConfRSSM) in Multi-Agent Systems

Selecting a suitable conflict resolution strategy when conflicts appear in multi-agent environments is a hard problem. There is a need to formulate a model for strategic decision making in selecting a strategy to resolve conflicts. In this paper, we formalise a model for selecting a conflict resolution strategy in multi-agent systems. The model is expected to select a suitable strategy which guaranties low cost in terms of the number of messages and time ticks. This paper focuses on a novel method to guide strategic decision making for conflict resolution. The proposed model is named as Conflict Resolution Strategy Selection Method (ConfRSSM). We identified three distinct types of intervention: (1) domain requirement, (2) conflict strength, and (3) confidence level of the conflicting agents. We also ascertain that the most appropriate conflict resolution strategy for a given conflict depends on the type of conflict (weak, strong), the agents’ confidence level, and the domain preferences. Our method explores the best strategic choices that will reduce the cost and time in selecting a strategy.
1-1-1 MASH $\Delta \Sigma$ Time-to-Digital Converters With 6 ps Resolution and Third-Order Noise-Shaping

Two 1-1-1 MASH ΔΣ time-to-digital converters (TDCs) are presented in this paper. Third-order time domain noise-shaping has been adopted by the TDCs to achieve better than 6 ps resolution. Following a detailed analysis of the noise generation and propagation in the MASH ΔΣ structure, the first prototyping TDC has been realized in 0.13 μm CMOS technology. It achieves an ENOB of 11 bits and consumes 1.7 mW from a 1.2 V supply. In the second MASH TDC, a delay-line assisted calibration technique is introduced to mitigate the phase skew caused by the large comparator delay, which is the main limiting factor of the MASH TDC's resolution. The demonstrated TDC achieves an ENOB of 13 bits and a wide input range of 100 ns. This TDC shows a temperature coefficient of 176 ppm°C within a temperature range of -20 to 120°C. It consumes only 0.7 mW and occupies 0.08 mm2 area (core).
Scheduling the games of the Portuguese major football league and referee assignment based on integer programming

This article aims to explore the problematic of game scheduling and referee assignment for the case of the first Portuguese football league. The final objective is to provide a computational tool capable of getting good solutions for both situations. Nowadays, each of those two tasks is developed by an independent organization. FPF takes care of the referee’s assignment while Liga de Clubes NOS is responsible for the game scheduling. Both problems have proper restrictions based on real requirements and will be modelled and solved recurring to binary integer programming. The solutions obtained by solving them were provided by two different software. CPLEX was used to get feasible scheduling solutions (schedules that satisfy all the restrictions used without considering any criteria) and also to assign referees to those games. Then, simultaneously, was used Wolfram Mathematica to treat the non linearity of the objective function of the scheduling model and implement it, in order to optimize the model and obtain better solutions. The objective function of the scheduling model will consider two different criteria where the first is related to the minimization of the number of consecutive home, or away, games of a team, breaks, and the second intends to minimize the consecutive games of smaller clubs against the biggest competitors. This dissertation will compare the results of both criteria used in the real timetable of the season 2014-2015 with the ones obtained by the model developed, and will also create and analyse two different approaches used to assign referees. The results obtained show that the proposed models optimise game scheduling and the referee assignment evidence that the actual models could be improved, with positive effects on competitiveness and fairness of portuguese championship. Those were presented to a FPF’s responsible whose reaction was very positive, when considering this work as a case study exercise. Index Terms – Sports Scheduling, Portuguese Football, Referee Assignment, Operations Research, Integer Programming, Binary Integer Programming 1Federação Portuguesa de Futebol. For further information about this organization consult the following website: http://www.fpf. pt/ 2For further information about this organization you can consult the following website: http://www.ligaportugal. pt/
Near-field scanning optical microscope with a metallic probe tip.

A near-field scanning optical microscope with a metallic probe tip was developed for detecting localized photons near the surface of the fine structure of a sample. In this microscope a metallic probe is used for converting the evanescent photons localized near the sample surface to the propagating scattering light wave; the scattered light is detected in the far field with external condenser optics. During the measurement the probe tip vibrates normal to the surface with an amplitude of ~5 nm at 2.5 kHz, and the light intensity modulated with this frequency is lock-in detected. This operation permits the removal of stray-light noise contribution. Experimental results of the measurements of the exponential decay of the evanescent field produced by total internal reflection are given with and without the probe vibration. Image data of the surface profile of an optical compact disk are also shown.
Clearance of systemic hematologic tumors by venetoclax (Abt-199) and navitoclax

The Bcl‐2 family inhibitors venetoclax and navitoclax demonstrated potent antitumor activity in chronic lymphocytic leukemia patients, notably in reducing marrow load and adenopathy. Subsequent trials with venetoclax have been initiated in non‐Hodgkin's lymphoma and multiple myeloma patients. Traditional preclinical models fall short either in faithfully recapitulating disease progression within such compartments or in allowing the direct longitudinal analysis of systemic disease. We show that intravenous inoculation of engineered RS4;11 (acute lymphoblastic leukemia) and Granta 519 (mantle cell lymphoma) bioluminescent reporter cell lines result in tumor engraftment of bone marrow, with additional invasion of the central nervous system in the case of Granta 519. Importantly, apoptosis induction and response of these systemically engrafted tumors to Bcl‐2 family inhibitors alone or in combination with standard‐of‐care agents could be monitored longitudinally with optical imaging, and was more accurately reflective of the observed clinical response.
Experiential Knowledge Mining

Recent advances in Internet and Web technologies and the advent of Web 2.0 have made it possible to share information and knowledge surrounding human activities, which can be obtained from massively deployed sensors and the Web resources. This survey provides a comprehensive overview of mining experiential knowledge bearing on human activities, with an emphasis on the use of the Web. Starting from definitions of activities and experiences, we elaborate on various views of human activities in cognitive science, including knowledge representation schemes. We then describe two activity detection techniques arising from different types of information sources: sensor-driven approaches for the physical space and text-driven approaches for the cyberspace. Focusing on experiential knowledge of human activities that can be discovered from unstructured text, we review and summarize the existing body of literature on experiential knowledge filtering, context identification for knowledge, and knowledge distillation. There is no doubt that the vast amount of information on human experience including activities is going to help detecting, recognizing, and understanding human activities of various sorts. We illustrate potential applications of experiential knowledge in different domains, such as information retrieval, service recommendation, and semantic Web. Following the survey of on-going research on capturing and utilizing human activities and experiences, we finally present challenging research issues for further research.
Cartilage Health in Knees Treated with Metal Resurfacing Implants or Untreated Focal Cartilage Lesions: A Preclinical Study in Sheep

Background Full-depth cartilage lesions do not heal and the long-term clinical outcome is uncertain. In the symptomatic middle-aged (35-60 years) patient, treatment with metal implants has been proposed. However, the cartilage health surrounding these implants has not been thoroughly studied. Our objective was to evaluate the health of cartilage opposing and adjacent to metal resurfacing implants. Methods The medial femoral condyle was operated in 9 sheep bilaterally. A metallic resurfacing metallic implant was immediately inserted into an artificially created 7.5 mm defect while on the contralateral knee the defect was left untreated. Euthanasia was performed at 6 months. Six animals, of similar age and study duration, from a previous study were used for comparison in the evaluation of cartilage health adjacent to the implant. Cartilage damage to joint surfaces within the knee, cartilage repair of the defect, and cartilage adjacent to the implant was evaluated macroscopically and microscopically. Results Six animals available for evaluation of cartilage health within the knee showed a varying degree of cartilage damage with no statistical difference between defects treated with implants or left untreated (P = 0.51; 95% CI −3.7 to 6.5). The cartilage adjacent to the implant (score 0-14; where 14 indicates no damage) remained healthy in these 6 animals showing promising results (averaged 10.5; range 9-11.5, SD 0.95). Cartilage defects did not heal in any case. Conclusion Treatment of a critical size focal lesion with a metal implant is a viable alternative treatment.
Datación de restos arqueológicos encontrados en Checua (Cundinamarca - Colombia) mediante resonancia paramagnética electrónica

En este trabajo se presentan los resultados obtenidos al datar por medio de resonancia paramagnetica electronica (RPE) muestras de esmalte dental humano provenientes del sitio arqueologico de Checua, situado a 5o 04’ de latitud norte y a 73° 53’ de longitud este, a una altitud de 3.600 m sobre el nivel del mar, y a 60 km al noreste de Bogota. El esmalte dental se irradio con rayos gama y los radicales libres producidos se cuantificaron usando un espectrometro de RPE, banda X. A partir de la curva de intensidad de la senal RPE, comparada con la dosis absorbida por el esmalte, se hizo un ajuste que permitio obtener la dosis media arqueologica acumulada en el esmalte (DE) durante el periodo de enterramiento de la muestra. El valor obtenido fue de 3,0 ± 0,08 Gy. Para estimar la edad de la muestra se uso el programa computacional ROSY, obteniendo una edad media del individuo de 5.021 ± 202 anos antes del presente. La edad de las muestras corresponde a seres humanos que vivieron en el periodo cuaternario, en la epoca del holoceno. Los resultados obtenidos muestran el potencial de la tecnica RPE como herramienta de datacion de muestras cuaternarias en Colombia y abre la posibilidad de usarla en otro tipo de muestras como estalagmitas, calcitas, conchas de moluscos y corales. Este trabajo es el tercero realizado en Colombia en este campo despues del trabajo de tesis de Sandoval y Carvajal (Sandoval 2010, Carvajal 2011 a,b)
Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months.

BACKGROUND Sinus augmentation with simultaneous implant placement without bone graft material is a hotly debated technique. This technique could be improved and secured by the use of an autologous leukocyte- and platelet-rich fibrin (PRF) (Choukroun's technique) concentrate. The objectives of this study were to assess the relevance of PRF clots and membranes as the sole filling material during a lateral sinus lift with immediate implantation using radiologic and histologic analyses in a case series. METHODS Twenty-five sinus elevations with simultaneous implantation were performed on 20 patients with Choukroun's PRF as the sole filling biomaterial. For each patient, a presurgical exam and a 6-month post-surgical radiologic exam were performed with a panoramic x-ray and three-dimensional volumetric computed radiography (VCR) to evaluate the subsinus residual bone height and the final bone gain around the implants. In nine patients, 6 months after the sinus lift, bone biopsies were collected on the buccal wall of the alveolar ridge at the level of the osteotomy window, and evaluated by histomorphometry. RESULTS In this study, 41 implants from three different systems with different screw designs (Biomet 3I Nanotite, MIS Seven, Intra-Lock Ossean) were placed. All implants were inserted in residual bone height between 1.5 and 6 mm (mean +/- SD: 2.9 +/- 0.9 mm). The final bone gain was always very significant (between 7 and 13 mm [mean +/- SD: 10.1 +/- 0.9 mm]). No implant was lost. After radiologic analyses, the position of the final sinus floor was always in the continuation of the end of the implant. All biopsies showed well organized and vital bone. CONCLUSIONS From a radiologic and histologic point of view at 6 months after surgery, the use of PRF as the sole filling material during a simultaneous sinus lift and implantation stabilized a high volume of natural regenerated bone in the subsinus cavity up to the tip of the implants. Choukroun's PRF is a simple and inexpensive biomaterial, and its systematic use during a sinus lift seems a relevant option, particularly for the protection of the Schneiderian membrane.
Transesophageal echocardiography (TEE)-induced Mallory-Weiss laceration in a patient who underwent aortic and mitral valve replacement -A case report-

Transesophageal echocardiography (TEE) is a relatively noninvasive and highly valuable diagnostic modality to monitor cardiac surgery. TEE is utilized to estimate the results of the surgical correction or the cardiac function on a real time basis. Accordingly, the frequency of TEE usage is increasing. Previous studies have shown low risk of TEE-associated complications; nonetheless, major gastrointestinal trauma can occur on a rare occasion. We herein present a case of Mallory-Weiss laceration after an intraoperative TEE examination.
The Archaeology of Identity: Approaches to Gender, Age, Status, Ethnicity and Religion

List of Figures Acknowledgements. 1. Introduction Margarita Diaz-Andreu and Sam Lucy 2. Gender identity Margarita Diaz-Andreu 3. The Archaeology of Age Sam Lucy 4. Status Identity and Archaeology Stasa Babic 5. Archaeology, Ethnic and Cultural Identities Sam Lucy 6. The Archaeology of Religion David N. Edwards Bibliography
jUCM: Universal Class Morphing (position paper)

We extend prior work on class-morphing to provide a more expressive pattern-based compile-time reflection language. Our MorphJ language offers a disciplined form of metaprogramming that produces types by statically iterating over and pattern-matching on fields and methods of other types. We expand such capabilities with "universal morphing", which also allows pattern-matching over types (e.g., all classes nested in another, all supertypes of a class) while maintaining modular type safety for our meta-programs. We present informal examples of the functionality and discuss a design for adding universal morphing to Java.
Reovirus infection in the pigeon.

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. REOVIRUS INFECTION IN THE PIGEON H. Vindevogel, G. Meulemans, P.-P. Pastoret, Anne Schwers, Claire-Michèle Calberg-Bacq
Has the mortality of septic shock changed with time.

OBJECTIVES To determine whether a systematic review of the literature could identify changes in the mortality of septic shock over time. DATA SOURCES A review of all relevant papers from 1958 to August 1997, identified through a MEDLINE search and from the bibliographies of articles identified. DATA SYNTHESIS The search identified 131 studies (99 prospective and 32 retrospective) involving a total of 10,694 patients. The patients' mean age was 57 yrs with no change over time. The overall mortality rate in the 131 studies was 49.7%. There was an overall significant trend of decreased mortality over the period studied (r=.49, p < .05). The mortality rate in those patients with bacteremia as an entry criterion was greater than that rate in patients whose entry criterion was sepsis without definite bacteremia (52.1% vs. 49.1%; chi2=6.1 and p< .05). The site of infection altered noticeably over the years. Chest-related infections increased over time, with Gram-negative infections becoming proportionately less common. If all other organisms and mixed infections are included with the Gram-positives, the result is more dramatic, with these organisms being causative in just 10% of infections between 1958 and 1979 but in 31% of infections between 1980 and 1997. CONCLUSIONS The present review showed a slight reduction in mortality from septic shock over the years, although this result should be approached with caution. The heterogeneity of the articles and absence of a severity score for most of the studies limited our analysis. Furthermore, there was an increasing prevalence of Gram-positive causative organisms, and a change of the predominant origin of sepsis from the abdomen to the chest.