Miracle-dz/UniFAR-FTUs huggingface dataset:
REST resource models from procedure-oriented service nterfaces

During the past decade a number of procedure-oriented protocols and standards have emerged for making service-offering systems available on the Web. The WS-∗ stack of protocols is the most prevalent example. However, this procedure and message-oriented approach has not aligned with the true potential of the Web’s own architectural principles, such as the uniform identification and manipulation of resources, caching, hypermedia, and layering. In this respect, Resource Oriented Architectures based on the REST architectural style, have been proposed as a possible alternative to the operation-based view of service offerings. To date, compiling a REST API for back-end procedure-oriented services is considered as a manual process that requires as input specialized models, such as, service requirements and behavioral models. In this paper, we propose a resource extraction method in which service descriptions are analyzed, using natural language processing techniques and graph transformations, in order to yield a collection of hierarchically organized elements forming REST resources that semantically correspond to the functionality offered by the service. The proposed approach has been applied as a proof of concept with positive results, for the extraction of resource models from a sizable number of procedure-oriented Web Service interfaces that have been obtained from an open service directory. © 2014 Elsevier Inc. All rights reserved.
Synergistic increases in intracellular Ca2+, and the release of MCP‐1, RANTES, and IL‐6 by astrocytes treated with opiates and HIV‐1 Tat

Recent evidence suggests that injection drug users who abuse heroin are at increased risk of CNS complications from human immunodeficiency virus (HIV) infection. Opiate drugs may intrinsically alter the pathogenesis of HIV by directly modulating immune function and by directly modifying the CNS response to HIV. Despite this, the mechanisms by which opiates increase the neuropathogenesis of HIV are uncertain. In the present study, we describe the effect of morphine and the HIV‐1 protein toxin Tat1‐72 on astroglial function in cultures derived from ICR mice. Astroglia maintain the blood‐brain barrier and influence inflammatory signaling in the CNS. Astrocytes can express μ‐opioid receptors, and are likely targets for abused opiates, which preferentially activate μ‐opioid receptors. While Tat alone disrupts astrocyte function, when combined with morphine, Tat causes synergistic increases in [Ca2+]i. Moreover, astrocyte cultures treated with morphine and Tat showed exaggerated increases in chemokine release, including monocyte chemoattractant protein‐1 (MCP‐1) and regulated on activation, normal T cell expressed and secreted (RANTES), as well as interleukin‐6 (IL‐6). Morphine‐Tat interactions were prevented by the μ‐opioid receptor antagonist β‐funaltrexamine, or by immunoneutralizing Tat1‐72 or substituting a nontoxic, deletion mutant (TatΔ31‐61). Our findings suggest that opiates may increase the vulnerability of the CNS to viral entry (via recruitment of monocytes/macrophages) and ensuing HIV encephalitis by synergistically increasing MCP‐1 and RANTES release by astrocytes. The results further suggest that astrocytes are key intermediaries in opiate‐HIV interactions and disruptions in astroglial function and inflammatory signaling may contribute to an accelerated neuropathogenesis in HIV‐infected individuals who abuse opiates. © 2004 Wiley‐Liss, Inc.
A 2G/3G Cellular Analog Baseband Based on a Filtering ADC

A current-driven low-pass filter embedded in a sigma-delta analog-to-digital converter is presented. The implementation of a class-B feedback digital-to-analog converter, together with in-band noise reduction and passive filtering, gives the possibility to handle challenging wireless communication scenarios with low power consumption. The architecture is a suitable candidate to implement the entire baseband analog section of a Global System for Mobile Communications-Universal Mobile Telecommunications System (GSM-UMTS) reconfigurable receiver.
Impacts of recent climate change on trends in baseflow and stormflow in United States watersheds

Characterizing the impacts of climatic change on hydrologic processes is critical for managing freshwater systems. Specifically, there is a need to evaluate how the two major components of streamflow, baseflow and stormflow, have responded to recent trends in climate. We derive baseflow and stormflow for 674 sites throughout the United States from 1980 to 2010 to examine their associations with precipitation, potential evapotranspiration, and maximum/minimum temperature. The northeastern (NE) and southwestern (SW) United States display consistent trends in baseflow and stormflow: increasing during fall and winter in the NE and decreasing during all seasons in the SW. Trends elsewhere and at other times of the year are more variable but still associated with changes in climate. Counter to expectations, baseflow and stormflow trends throughout the United States tend to change concurrently. These trends are primarily associated with precipitation trends, but increases in PET are influential and likely to become important in the future.
The Hypercoagulable State in Thalassemia Intermedia

Although the life expectancy of β-thalassemia patients has markedly improved over the last few years, patients still suffer from many complications of this congenital disease. The presence of a high incidence of thromboembolic events, mainly in β-thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients. In this review, the molecular and cellular mechanisms leading to hypercoagulability in β-thalassemia are highlighted, with a special focus on thalassemia intermedia being the group with the highest incidence of thrombotic events as compared to other types of thalassemia. Recommendations for thrombosis prophylaxis in these patients are also discussed.
A Systematic Mapping Study on Domain-Specific Languages

Domain-Specific Languages (DSLs) offer substantial gains in expressiveness and ease of use compared with general purpose languages. This way, DSLs have gained significant attention in industry and academy, as can be seen by the increased number of related publications in key conferences and journals. This paper aims to provide a broad view of the DSL research field by performing a Systematic Mapping Study. Adopting a detailed search strategy, 4450 studies were initially identified, and, after filtering, 1440 primary studies were selected and categorized using a particular classification scheme. So, this work presents the most popular application domains where DSLs have been applied, identifies different tools for handling DSLs, including language workbenches, and enumerates several techniques, methods and/or processes for dealing with DSLs.
Actin Assembly at Membranes Controlled by ARF6

The small GTPase, ADP‐ribosylation factor‐6 (ARF6), has been implicated in regulating membrane traffic and remodeling cortical F‐actin. Using real‐time video analysis of actin assembly in living cells, we investigated the function and mechanism of ARF6 in control of actin assembly. Expression of an activated form of ARF6 that mimicks the GTP‐bound form of the GTPase induced actin assembly resulting in the movement of vesicle‐like particles, some of which contain markers for pinosomes. Activated ARF6 also stimulated actin assembly at foci on the ventral surface of the cell and stimulated fluid phase pinocytosis. Particle motility induced by ARF6 involved Arp2/3 complex, tyrosine kinase activity, phospholipase D (PLD) and D3‐phosphoinositides, but not phosphatidylinositol 4,5‐bisphosphate (PI(4,5)P2). We conclude that ARF6 regulates actin assembly for pinosome motility and at foci on the ventral cell surface.
The evolutionary genetics of personality: Does mutation load signal relationship load?

The mutation-selection hypothesis may extend to understanding normal personality variation. Traits such as emotional stability, agreeableness, and conscientiousness figure strongly in mate selection and show evidence of non-additive genetic variance. They are linked with reproductively relevant outcomes, including longevity, resource acquisition, and mating success. Evolved difference-detection adaptations may function to spurn individuals whose high mutation load signals a burdensome relationship load.
Unfolding pathway of the colicin E1 channel protein on a membrane surface.

The channel-forming domain of colicin E1 is composed of a soluble helical bundle which, upon membrane binding, unfolds to form an extended, two-dimensional helical net in the membrane interfacial layer. To characterize the pathway of unfolding of the protein and the structure of the surface-bound intermediate, the time-course of intra-protein distance changes and unfolding on a millisecond time-scale were determined from the kinetics of changes in the efficiency of fluorescence resonance energy transfer, and of the donor-acceptor overlap integral, between each of six individual tryptophan residues and a Cys-conjugated energy transfer acceptor (C509-AEDANS). Comparison of the rate constants revealed the following order of events associated with unfolding of the protein at the membrane surface: (A) movement of the hydrophobic core helices VIII-IX, coincident with a small change in Trp-Cys509 distances of the outer helices; (B) unfolding of surface helices in the helical bundle in the order: helix I, helices III, IV, VI, VII, and helix V; (C) a slow (time-scale, seconds) condensation of the surface-bound helices. The rate of protein unfolding events increased with increasing anionic lipid content. Unfolding did not occur below the lipid thermal phase transition, indicating that unfolding requires mobility in the interfacial layer. The structure of the two-dimensional membrane-bound intermediate in the steady-state was inferred to consist of a quasi-circular arrangement of eight helices embedded in the membrane interfacial layer and anchored by the hydrophobic helical hairpin. The pathway of unfolding of the colicin channel at the membrane surface, catalyzed by electrostatic and hydrophobic forces, is the first described for a membrane-active protein. It is proposed that the pathway and principles described for the colicin protein are relevant to membrane protein import.
Virages de l’humeur lors d’une cure d’électroconvulsivothérapie, revue de la littérature, description de cas cliniques

L’ElectroConvulsivoTherapie (ECT) est un traitement de choix en premiere ou deuxieme intention dans les troubles de l’humeur, en particulier les episodes depressifs majeurs d’intensite severe. Ceci est valide au niveau international et apparait dans les differentes recommandations actuelles. Cependant, cette technique provoque des effets secondaires non negligeables au niveau cognitif et mnesique. Il existe de nombreuses etudes les decrivant ainsi que des recherches en cours pour les reduire. Un phenomene moins bien identifie mais pourtant decrit depuis le debut de l’utilisation de l’ECT est le virage de l’humeur lors d’une cure, principalement dans le sens depression – manie. Les virages de l’humeur peuvent etre spontanes ou declenches, de nombreux facteurs peuvent alors etre mis en cause. L’ECT et les autres techniques de stimulation cerebrales sont maintenant identifiees comme des facteurs susceptibles de favoriser un virage de l’humeur. Or, il n’existe pas de recommandation pour la prise en charge d’un tel evenement chez le patient. Le DSM V qualifie pourtant le virage de l’humeur sous ECT comme un critere de bipolarite de type I. Quatre cas cliniques illustrant des differences majeurs de pratiques sont rapportes dans ce travail venant confirmer la necessite d’etablir une recommandation.
Resistance Training vs. Static Stretching: Effects on Flexibility and Strength

Morton, SK, Whitehead, JR, Brinkert, RH, and Caine, DJ. Resistance training vs. static stretching: Effects on flexibility and strength. J Strength Cond Res 25(12): 3391–3398, 2011—The purpose of this study was to determine how full-range resistance training (RT) affected flexibility and strength compared to static stretching (SS) of the same muscle–joint complexes in untrained adults. Volunteers (n = 25) were randomized to an RT or SS training group. A group of inactive volunteers (n = 12) served as a convenience control group (CON). After pretesting hamstring extension, hip flexion and extension, shoulder extension flexibility, and peak torque of quadriceps and hamstring muscles, subjects completed 5-week SS or RT treatments in which the aim was to stretch or to strength train the same muscle–joint complexes over similar movements and ranges. Posttests of flexibility and strength were then conducted. There was no difference in hamstring flexibility, hip flexion, and hip extension improvement between RT and SS, but both were superior to CON values. There were no differences between groups on shoulder extension flexibility. The RT group was superior to the CON in knee extension peak torque, but there were no differences between groups on knee flexion peak torque. The results of this preliminary study suggest that carefully constructed full-range RT regimens can improve flexibility as well as the typical SS regimens employed in conditioning programs. Because of the potential practical significance of these results to strength and conditioning programs, further studies using true experimental designs, larger sample sizes, and longer training durations should be conducted with the aim of confirming or disproving these results.
Distribution of Seeds in Sonoran Desert Soils: Implications for Heteromyid Rodent Foraging.

We used a hierarchical sampling design to investigate temporal and spatial patterns of variation in the topsoil seedbank at a site on the Santa Rita Experimental Range, 50 km south of Tucson, Arizona. Replicate sets of contiguous 4 ° 4 cm samples to 2 cm depth ("transects") were collected three times per year, from 1980 to 1983, from four microhabitats that are differentiated by desert heteromyid rodents: large and small open spaces, under canopies of large shrubs, and under canopies of small trees. We also analyzed texture and organic content of soils from the four microhabitats. Seeds from 54 plant taxa were encountered, most of them rare. Average seed mass across species was 1.28 mg/seed, but because tiny seeds were most numerous, the abundance-weighted average was 0.16 mg/seed. Total seed abundance was highly variable, ranging from 0 to 256 seeds and from 0 to 146 mg per sample. The fourfold temporal variation in mean mass or number of seeds per sample was largely due to between-year rather than between-season effects. Seed standing crops were positively correlated with rainfall during the previous 6-mo rainy period, and were lowest in fall and winter of 1982 after 2 yr of poor winter rains. Mean seed number per sample, which reflects primarily abundance of tiny seeds, did not vary among microhabitats. Mean per-sample seed mass, which reflects abundance of the large seeds eaten by rodents, did vary among microhabitats, however, with values being higher under shrubs and trees than in open spaces. The low mean abundance in open spaces was due more to a high frequency of seedless samples than to low maximum per-sample abundance. Hence, profitable seed patches do occur in open spaces, but are rarer than under shrubs or trees. Within microhabitats there was significant variation among replicate transects and among samples within transects. On a local scale, seeds occurred in patches 12 cm in diameter in all microhabitats and sampling periods. Seed species composition varied seasonally and among microhabitats, and there was an overall correlation between seed and adult microhabitat distribution for spring ephemerals. Soil from open spaces was finer and had lower organic content than that under shrub or tree canopies. Our results suggest that the resource upon which desert granivores depend is highly variable in time and space. Microhabitat is one of the most conspicuous sources of variation, and heteromyid rodent species differ in use of those microhabitats (open spaces vs. areas under canopies of perennial plants) that differ most noticeably in seed abundances, species composition, and soil characteristics.
How I treat paediatric relapsed acute myeloid leukaemia

The prognosis of paediatric acute myeloid leukaemia (AML) has improved significantly over the recent decades, but still about one‐third of patients relapse. These patients have a relatively poor prognosis, with a probability of long‐term survival from relapse of about 35%. This can only be achieved with very intensive chemotherapy and, usually, allogeneic stem cell transplantation, leading to very significant toxicity and even treatment‐related mortality. Major improvements in the treatment of paediatric relapsed AML thus are required still, and several possibilities are discussed. In case of a suspected relapse, a comprehensive diagnostic work‐up has to be undertaken, because significant changes in the biological features of the AML cells may have occurred between initial diagnosis and relapse. This review discusses many practical issues that one encounters in the treatment of children with relapsed AML. It will also be of interest for those involved in translational research in AML.
Efficiency Measurement of Bank Branches with Undesirable Output Using Non-Radial Models of Data Envelopment Analysis

Today, banks, as intermediaries, seek to attract and allocate resources to obtain greater benefit. Therefore, the bank assessment is considered as an important subject in the banking industry. Data envelopment analysis is an effective technique in evaluating the efficiency of decision-making units. There are factors among banking indices (such as receivables from resource allocation) that are inevitably created along with desirable outputs. Therefore, the existence of a model for evaluating bank performance in the presence of poor outcomes is very important. In this study, a collection of Iranian commercial bank branches were investigated from this perspective, and radial and non-radial models were provided to measure relative efficiency in the presence of undesirable factors.
A proposed framework for building a recommender search engine

There are billions of web pages had been hosted in the Internet and the number of documents is increased overtime. But since internet is a huge resource, the problem of how to determine what users need to give good search results is a challenge for many search engines. This paper suggest a framework for building general purposed search engines which can recommend search results (web pages) to user by using a hybrid recommender engine from content-based and collaborative filtering. This framework determines the roles of topics, websites and web pages and give recommendations rely on the mutual relation of the triple topics, websites, and web pages. With this approach, we can improve search quality of search engines and solve some problems that restricted recommender systems. Experimental results show that our search results better than search results of a search engine apply classical Google page rank algorithm (13), a well-known page rank algorithm used in many search engines.
Characterization and Wideband Modeling of Miniaturized LTCC Helical Inductors

We report fabrication of miniaturized low temperature co-fired ceramic helical (3-D) inductors with more than seven layers of helices and the conductor linewidth of 100mum. We achieve the QmaxLeff/A product ranging from 200 to 370. Such high values are possible thanks to the drastic reduction of the active area and still acceptably large Qmax and self-resonant frequency. High frequency characterization of the inductors is performed up to 12GHz, and a new equivalent circuit model considering vertical electromagnetic coupling between conductors is shown to reproduce all the measured characteristics
Untersuchung zum Einfluss prognostischer Faktoren und therapeutischer Maßnahmen auf den Krankheitsverlauf von Patienten mit Rezidiven von Plattenepithelkarzinomen der Mundhöle: dargestellt am Krankengut der Chemnitzer Klinik für Mund-, Kiefer- und Gesichtschirurgie von 1984 - 2000

Trotz groser Fortschritte in der Diagnostik und den verbesserten Therapiemoglichkeiten hat sich die 5-Jahres-Uberlebensrate von Patienten mit bosartigen Tumoren der Mundhohle nur wenig verbessert. Treten Rezidive auf, sinkt die Chance fur das Uberleben drastisch. Von 90 Rezidivpatienten, die aus einem Patientenkollektiv von 308 Patienten hervorgingen, uberleb-ten 11,1%. Drei Viertel der Patienten waren Manner, die in jungeren Jahren erkrankten als Frauen. Einen deutlichen Einfluss auf den Krankheitsverlauf hatten Grading, Tumorlokalisa-tion, Zeitspanne zwischen Diagnosestellung und Behandlungsbeginn, Art der Metastasierung und Therapieverfahren.
Filter Bank Design for DFT Based Transmultiplexers

This paper investigates the application of filter bank design techniques on the DFT based transmultiplexers to ameliorate the effects of in-band aliasing and consequently improve the performance of the system. With this approach, one is allowed flexibility in the design of the synthesis and analysis filters. Hence, a suitable prototype filter can be selected and specific values assigned to its parameters, namely the cut-off frequency, main lobe width and side lobe amplitudes so as to construct an ideal filter for optimal recovery. Investigation results depict that increasing the cut-off frequency of the prototype filter by a small increment delta, enhances system performance through the widening of the stopband tolerance region which reduces the effect of aliasing. Simulations also show that using a Kaiser prototype filter with a wide main lobe and low side lobe amplitudes generates the most favorable results. Moreover, it was observed that the performance of the transmultiplexer can be improved by increasing the number of sub-carriers and oversampling factor. The evaluation of the transmultiplexer structure for this paper was assessed in terms of its bit error rate (BER) performance