Miracle-dz/UniFAR-FTUs huggingface dataset:
Antithymocyte globulin for patients with myelodysplastic syndrome

Twenty‐five transfusion‐dependent myelodysplastic syndrome (MDS) patients (with < 20% blasts) were treated in a phase II study with antithymocyte globulin (ATG) at 40 mg/kg/d for four doses and then followed with blood counts every 2 weeks and clinic visits every 3 months, for a median of 14 months (range 1–38 months). 11 (44%) patients responded and became transfusion‐independent after ATG, including three complete responses, six partial responses, and two minimal responses. Responses were observed in 9/14 patients (64%) with refractory anaemia (RA) and 2/6 patients (33%) with refractory anaemia with excess blasts (RAEB). Median response duration was 10 months (range 3–38 months). The Kaplan‐Meier estimate of overall survival was 84% at 38 months, with one early death due to pneumonia and two deaths from disease progression to leukaemia. Side‐effects consisted mainly of mild serum sickness in all patients. A single course of ATG restored haemopoiesis in some patients with MDS and was well tolerated.
Comparison of IEEE 802.11e and IEEE 802.15.3 MAC

IEEE 802.11 and IEEE 802.15. 3 target at designing PHY and MAC specifications for wireless local area network (WLAN) and wireless personal area network (WPAN), respectively. They adopt different philosophies for MAC design, namely CSMA/CA in 802.11 and TDMA in 802.15. 3. An interesting problem is the performance of each MAC working on the same physical layer, e.g., ultra wideband (UWB). This problem has gained much attention in industry standard meetings recently. In this paper, we compare the performance of two access methods defined in IEEE 802.11e (hybrid coordination function (HCF)) and IEEE 802.15. 3 (TDMA) under the same UWB physical layer in terms of the throughput and power management. The results show that the newly added mechanisms of 802.11e, such as transmission opportunity (TXOP) and Block Ack, improve its throughput greatly, making it comparable to that of 802.15. 3. In addition, 802.15. 3 MAC has easier power management by utilizing its TDMA access method.
Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

T cells activated by antigen receptor stimulation in the absence of accessory cell-derived costimulatory signals lose the capacity to synthesize the growth factor interleukin-2 (IL-2), a state called clonal anergy. An analysis of CD3- and CD28-induced signal transduction revealed reduced ERK and JNK enzyme activities in murine anergic T cells. The amounts of ERK and JNK proteins were unchanged, and the kinases could be fully activated in the presence of phorbol 12-myristate 13-acetate. Dephosphorylation of the calcineurin substrate NFATp (preexisting nuclear factor of activated T cells) also remained inducible. These results suggest that a specific block in the activation of ERK and JNK contributes to defective IL-2 production in clonal anergy.
Design and Evaluation of Agents that Sequence and Juxtapose Short Musical Patterns in Real Time

Abstract We present and discuss the Agent Designer, a system that enables users of digital audio workstations to generate novel high-level structures for their compositions based on previous examples. The system uses variable-order Markov models and rule induction to learn both temporal relations and structural relations between parts in a piece of music. As is usual in machine learning, however, the quality of the learning can be improved greatly by users specifying relevant features. The Agent Designer therefore points to important design and human–computer interaction problems, as well as algorithmic challenges. We present a number of studies that help to understand how effective the Agent Designer is and how we might design a user interface that best enables users to obtain quality results from the system. We show that the Agent Designer is effective for certain musical styles, such as loop-based electronic music, and that we as expert users can design agents that produce the most effective results. We also note that it remains a challenge to automate this process fully.
Cluster Headache: Transcranial Doppler Ultrasound and rCBF Studies

Transcranial Doppler and rCBF examinations were carried out in 25 cluster headache patients. Spontaneous and glyceryl trinitrate (nitroglycerin) provoked attacks were accompanied by a bilateral decrease in middle cerebral artery blood flow velocities. This decrease was more pronounced on the symptomatic side but the difference did not reach statistical significance. Mean hemispheric blood flow and rCBF were within normal limits during provoked attacks and similar to those found when patients were attack-free. During cluster periods middle cerebral artery velocities were significantly higher on the symptomatic side. Glyceryl trinitrate caused a bilateral middle cerebral artery velocity decrease which was significantly greater on the symptomatic side. Attacks provoked by glyceryl trinitrate appeared to begin when the vasodilatory effect of this substance was receding.
Relative motion model including J/sub 2/: derivation and application to INSAR

In the growing field of formation flying, most models in literature are devoted to control problems rather than to the issue of designing the orbits on the basis of mission requirements. In this paper, the authors present an analytical model which allows a time-explicit representation of relative motion on the basis of orbital parameters' differences between satellites, in the case of a reference satellite moving on a circular or slightly eccentric orbit. Both derivations take into account secular Earth oblateness effects. Numerical analyses show that, in typical cases of interest, equations' errors are of the order of 0.1% of relative motion coordinates, and grow very slowly with time. Application of the derived model to interferometric and bistatic missions proposed in literature allows to rediscover and better interpret results of numerical optimization of given formations, and to point out possibilities deriving from the evolution of relative trajectory
Role of Chest Low-dose Computed Tomography in Elderly Patients with Suspected Acute Pulmonary Infection in the Emergency Room

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Ozone modifies associations between temperature and cardiovascular mortality: analysis of the NMMAPS data

Objectives: Both ambient ozone and temperature are associated with human health. However, few data are available on whether ozone modifies temperature effects. This study aims to explore whether ozone modified associations between maximum temperature and cardiovascular mortality in the USA. Methods: The authors obtained data from the US National Morbidity, Mortality, and Air Pollution Study (NMMAPS) website. They used two time-series Poisson regression models (a response surface model and a stratification model) to examine whether ozone modified associations between maximum temperature and cardiovascular mortality (CVM) in 95 large US communities during 1987–2000 in summer (June to September). Bayesian meta-analysis was used to pool estimates in each community. Results: The response surface model was used to examine the joint effects of temperature and ozone on CVM in summer. Results indicate that ozone positively modified the temperature-CVM associations across the different regions. The stratification model quantified the temperature-CVM associations across different levels of ozone. Results show that in general the higher the ozone concentration, the stronger the temperature-CVM associations across the communities. A 10°C increase in temperature on the same day was associated with an increase in CVM by 1.17% and 8.31% for the lowest and highest level of ozone concentrations in all communities, respectively. Conclusion: Ozone modified temperature effects in different regions in the USA. It is important to evaluate the modifying role of ozone when estimating temperature-related health impacts and to further investigate the reasons behind the regional variability and mechanism for the interaction between temperature and ozone.
How I Learned to Stop Worrying and Love NoSQL Databases

The absence of a schema in NoSQL databases can disorient tradi- tional database specialists and can make the design activity in this context a leap of faith. However, we show in this paper that an effective design methodology for NoSQL systems supporting the scalability, performance, and consistency of next-generation Web applications can be indeed devised. The approach is based on NoAM (NoSQL Abstract Model), a novel abstract data model for NoSQL databases, which is used to specify a system-independent representation of the application data. This intermediate representation can be then implemented in target NoSQL databases, taking into account their specific features.
THUIR at TREC 2003: HARD Experiments

In this paper, we describe ideas and related experiments of Tsinghua University IR group in TREC-12 HARD Track. In this track, we focus on an automatic delivering mechanism, which combine the existing IR methods and can provide a quick retrieval solution for the practical environment. The final official evaluation show the old ways perform not well, but we think the experiment data will be helpful in evaluating the new ideas developed by other teams.
Encystment ‐ specific mRNA is accumulated in the resting cysts of the ciliate Colpoda inflata

From a random amplified polymorphism cDNA study using vegetative, precystic and mature resting cysts of the ciliate Colpoda inflata, a stage‐specific fragment was isolated from the resting cyst cDNA population. This fragment was used as an encystment probe to study the corresponding mRNA expression during this eukaryotic cell differentiation process. This transcript is accumulated in the resting cyst of this ciliate, and it is the first time that accumulation of specific mRNA molecules associated with the ciliate cryptobiosis process is reported. The meaning of this stored mRNA in microbial cryptobiotic stages is discussed.
Fine-structure mapping and identification of two regulators of capsule synthesis in Escherichia coli K-12

Positive and negative regulatory elements involved in the synthesis of colanic acid, the capsular polysaccharide of Escherichia coli K-12, have been identified previously. RcsB, a positive regulator for transcription of the structural genes of colanic acid synthesis (cps), is a protein of about 26 kilodaltons which probably acts as a multimer, rcsC, which maps close to rcsB at 48 min on the E. coli chromosome, exerts a negative effect on expression of the structural genes and codes for a protein of about 100 kilodaltons. The two genes appear to be transcribed in opposite directions, with the C-terminal ends of the genes being less than 0.3 kilobases apart. Multicopy expression of rcsB is lethal in rcsC mutants which carry cps-lac fusions, probably owing to accumulation of intermediates in the capsule synthesis pathway in these cells. Examination of double mutants and cells carrying multicopy rcsB+ plasmids reveal an rcsA-independent pathway for capsule synthesis. We hypothesize that RcsC may act as an environmental sensor, transmitting information to the RcsB positive regulator.
Short-term monitoring of the vascular resistance of the human skin microvasculature.

OBJECTIVE AND METHOD Laser Doppler flowmetry is a non-invasive tool in assessing the temporary changes of skin microcirculation. Another non-invasive equipment the Finapres 2300 finger blood pressure monitor provides a continuous blood pressure signal. The combination of the two devices allows short-term monitoring of the changes in the resistance of skin microvasculature. In order to assess the role of skin blood vessels in physiological responses to complex reflex tests Valsalva manoeuvre was performed by 12 healthy volunteers. For comparison a thermal stimulation (cold pressor) test was also done. RESULTS The two tests resulted in skin blood flow responses of similar magnitude. The changes in calculated regional peripheral resistance (dRPR) indicated that both responses involved active vasoconstrictor mechanisms. It is of importance that the active vasoconstriction could be documented only at the late strain phase (V2) but not in the early strain phase (V1) of the Valsalva manoeuvre (%dRPR in V1 = 0.14 vs. V2 = 0.96, p < 0.05). CONCLUSIONS In conclusion our findings support the theory that changes in the tone of the skin blood vessels parallel the changes in systemic vasculature in response to complex reflex tests. This is the first report which documents the feasibility of the continuous monitoring of the regional peripheral resistance.
Correlation Pattern Recognition

Correlation is a robust and general technique for pattern recognition and is used in many applications, such as automatic target recognition, biometric recognition and optical character recognition. The design, analysis and use of correlation pattern recognition algorithms requires background information, including linear systems theory, random variables and processes, matrix/vector methods, detection and estimation theory, digital signal processing and optical processing. This 2005 book provides a needed review of this diverse background material and develops the signal processing theory, the pattern recognition metrics, and the practical application know-how from basic premises. It shows both digital and optical implementations. It also contains technology presented by the team that developed it and includes case studies of significant interest, such as face and fingerprint recognition. Suitable for graduate students taking courses in pattern recognition theory, whilst reaching technical levels of interest to the professional practitioner.
Radial and Tangential Neuronal Migration Disorder in Ibotenate-Induced Cortical Lesions in Hamsters: Immunohistochemical Study of Reelin, Vimentin, and Calretinin

To investigate the mechanisms of radial and tangential neuronal migration disorders, immunohistochemical expressions of reelin, vimentin, and calretinin were examined in brain lesions induced by ibotenate (an agonist of the N-methyl-D-aspartate [NMDA] complex receptor) in hamsters. Thirty-four newborn hamsters were subjected to intracerebral injections of ibotenate, and 12 animals served as the control. These hamsters were examined at 1, 2, 3, 5, and 7 days after injections. The cortical lesions observed after ibotenate injections had a strong resemblance to the following neuronal migration disorders: (1) microgyria, (2) focal subcortical heterotopia, and (3) leptomeningeal glioneuronal heterotopia. In microgyria, the radial glial fibers were sparsely distributed, but in leptomeningeal glioneuronal heterotopia, vimentin-positive fibers extended into this abnormal neural tissue. Calretinin-immunoreactive neurons and fibers were present along the lesion forming the microgyria and abnormal neuronal arrangement. Focal subcortical heterotopia also included a small number of calretinin-expressing neurons originating from the subplate neuronal population. These results imply that the neuronal migration disorders produced by ibotenate show not only the migrational arrest of neurons but also interference from the termination of the migration process. We also suggest that the heterotopic neurons constituting the focal subcortical heterotopia originate in the lateral or medial ganglionic eminence of the ventral telencephalon, probably caused by the abnormal tangential neuronal migration. (J Child Neurol 2004;19:107—115).
后现代语境下的《Gangnam Style》

《GangnamStyle》是2012年风靡网络的一部音乐电视作品,它病毒式地迅速广泛传播,并在全世界范围内掀起一股模仿其骑马舞的热潮. 韩国文化的高度商品化和高度媒介化,社会经济的后现代语境,是《GangnamSty1e》生成后现代性的重要原因. 《GangnamStyle》削平了深度,有着显著的技术美学因素；而且,不论从音响构成、“鸟叔”的草根形象以及镜头剪辑都有着后现代主义解构特征；“鸟叔”在这部音乐电视中是卑琐性的自由释放的狂欢内体,作品所带来的社会影响也充满了狂欢化特质.
[Tear film and lacrimal excretion changes after lacrimal gland tumor removal].

OBJECTIVE To study the change of tear film and lacrimal secretion after lacrimal gland tumor removal operation. METHODS It was a retrospective case series study. Nineteen cases (19 eyes) with pleomorphic adenoma of the lacrimal gland from January, 2010 to July, 2011 in Eye and ENT Hospital of Fudan University were elected. The evaluation included subjective complaints of dry eye, tear break up time (BUT), reflex lacrimal secretion, corneal fluorescein staining, and size of lacrimal lake were analyzed before surgery and 3 days, 1 month and 6 months postoperatively. Simultaneously, the opposite eye was set as control. RESULTS Subjective complaints of dry eye increased and the mean tear break up time, reflex lacrimal secretion, and size of lacrimal lake were significantly reduced (t = 23.91, 16.90, 11.47; t = 19.31, 20.81, 11.95, P < 0.05) on day 3 and 1 month after operation which were (4.9 ± 2.0) s (3 d), (5.2 ± 1.6) s (1 moth); (4.05 ± 2.07) mm (3 d), (3.58 ± 1.98) mm (1 moth); (0.009 ± 0.004) mm(2) (3 d), (0.008 ± 0.003) mm(2)(1 moth) respectively. However, only reflex secretion test (3.53 ± 1.50 mm) was significantly reduced (t = 21.57, P < 0.05), other values (BUT: 17.4 ± 4.9 s, size of lake: 0.032 ± 0.005 mm(2)) recovered to preoperative levels by the time of the sixth month follow up visit. Corneal fluorescein staining score increased greatly when measured at day 3 and 1 month visit (t = 0.23, 1.69, P < 0.05), but had returned to preoperative values at the sixth month visit. The result of the opposite eye control is the same as preoperative control. CONCLUSIONS During the early stage after lacrimal gland tumor removal, tear film present abnormal changes, mainly in tear stability and reduction of reflex lacrimal secretion.
A 0.83-2.5-GHz continuously tunable quadrature VCO

A quadrature VCO with /spl plusmn/50% continuous 0.83-2.5-GHz tuning range is presented. It is based on a core LC-QVCO with /spl plusmn/20% tuning range, a single sideband mixer (SSBM), two frequency dividers and a multiplexer. The circuit has been implemented in a 0.13-/spl mu/m 1.2-V CMOS technology. The additional area with respect to the core LC-QVCO is 100 /spl mu/m/spl times/100 /spl mu/m. Quadrature error is less than 2/spl deg/; the phase noise is less than -120 dBc/Hz @ 1 MHz over the whole tuning range and is mainly due to the LC-QVCO. Spurs are more than 34 dB below the fundamental in the worst case.
Analysis of Satellite Image Time Series Based on Information Bottleneck

Derived from Information Theory, the Information Bottleneck principle enables to quantify and qualify the information contained in a signal. This paper presents an algorithm based on the Information Bottleneck principle to analyze Satellite Image Time Series (SITS). The method is composed of a parameter estimation and a model selection. This method has been previously applied to textural and radiometric parametric models and we propose here to extend it to take into account the geometry information. Two approaches are presented. In the first approach, each image of the SITS is segmented and the obtained regions are described by textural models. The Information Bottleneck method is further used to characterize the image segments of the SITS a spatio‐temporal way. In the second method, the geometrical information is extracted from a temporal adjacency graph of the spatial regions, and the radiometric and textural information is then extracted through the Information Bottleneck method. This approach leads to.
Medical treatment of symptomatic hiatus hernia with low-density compounds.

SummaryTwenty-eight patients with hiatus hernia and severe symptoms of oesophageal reflux completed a double-blind cross-over trial in which compounds designed to float on gastric contents were administered. Each patient received an alginate/antacid compound (‘Gaviscon’), alginate without antacid and ‘placebo’ inr andomized order for periods of two weeks. Significant relief of both regurgitation and heartburn was achieved with the alginate I antacid compound despite its low antacid content. The mode of action of alginate is discussed and, as alginate without antacid is only marginally better than placebo, it seems probable that it facilitates placement of antacid in the upper stomach and lower oesophagus. † ‘Gaviscon’ is a trade mark of Reckitt and Colman Limited.
Successful non‐neurotoxic therapy (without radiation) of a multifocal primary brain lymphoma with a methotrexate, vincristine, and BCNU protocol (DEMOB)

A 3.5‐year‐old boy with a multifocal primary lymphoma of the brain was treated successfully without neurotoxicity with a treatment regimen that did not include radiation. The protocol of Dexacort (dexamethasone), methotrexate, Oncovin (vincristine), and BCNU (carmustine) (DEMOB), which was developed with the use of MTX pharmocokinetic studies, was given over 7.5 months, and resulted in tumor disappearance on computerized tomography scans and marked improvement in clinical status. The patient remains in good health 3 years after diagnosis (March 1985).
Quality of life as an outcome in clinical trials and cancer care: A primer for surgeons

The importance of quality of life as a treatment outcome is intuitively understood by clinicians because it is inherent in ancient medical precepts. Most surgeons believe they should always aim to relieve suffering; subordinating that goal only to an opportunity for cure. Most appreciate that the balance between these two goals can occasionally be dif®cult to strike and believe that objective measurement of health related quality of life should only improve this art. They know what they mean by the term `̀ quality of life. '' However, health-related quality of life as something that can actually be measured has been dif®cult to de®ne; precisely because the phrase elicits near universal understanding of what is meant despite the fact that it actually covers a diversity of beliefs and expectations. Still, there is a well-established discipline of psychometric research that has devoted itself to this task and made substantial progress in the de®nition and measurement of quality of life over the past 25 years. The number of articles identi®ed in a medline search by the search terms `̀ quality of life'' has increased almost tenfold. One thousand six hundred and eighteen articles were published between 1975 and 1986, 4,477 from 1987 to 1992, 6,558 from 1993 to 1996, and 10,108 between 1997 and 2000. However, many of these clinical articles are felt by experts in the ®eld to be of uneven quality in their assessment of health related quality of life [1±3]. The confusion experienced by clinicians venturing into this area of study is often semantic; arising from a misunderstanding of what is really being measured when quality of life data is collected, as well as uncertainty about the vocabulary of psychometric research. The purpose of this article is to explain some of these issues to a newly enlarged and interested surgical audience. WHAT DOES MEASURING `̀ QUALITY OF LIFE'' MEAN?