Miracle-dz/UniFAR-FTUs huggingface dataset:
HOL-TestGen 1.8.0 User Guide

ion Techniques: model-checking raised interest in techniques to abstract infinite to finite models. Provided that the abstraction has been proven sound, testing may be sufficient for establishing correctness [11, 19]. Systematic Testing: the discussion over test adequacy criteria [32], i. e. criteria solving the question “when did we test enough to meet a given test hypothesis,” led to more systematic approaches for partitioning the space of possible test data and the choice of representatives. New systematic testing methods and abstraction techniques can be found in [24, 21]. Specification Animation: constructing counter-examples has raised interest also in the theorem proving community, since combined with animations of evaluations, they may help to find modeling errors early and to increase the overall productivity [10, 25, 18]. The first two areas are motivated by the question “are we building the program right? ” the latter is focused on the question “are we specifying the right program? ” While the first area shows that Dijkstra’s Verdict is no longer true under all circumstances, the latter area shows, that it simply does not apply in practically important situations. In particular, if a formal model of the environment of a software system (e. g. based among others on the operation system, middleware or external libraries) must be reverse-engineered, testing (“experimenting”) is without alternative (see [15]). Following standard terminology [32], our approach is a specification-based unit test . In general, a test procedure for such an approach can be divided into: Test Case Generation: for each operation the pre/postcondition relation is divided into subrelations. It assumes that all members of a sub-relation lead to a similar behavior of the implementation. Test Data Generation: (also: Test Data Selection) for each test case (at least) one representative is chosen so that coverage of all test cases is achieved. From the resulting test data, test input data processable by the implementation is extracted. Test Execution: the implementation is run with the selected test input data in order to determine the test output data. Test Result Verification: the pair of input/output data is checked against the specification of the test case.
ConMan: a visual programming language for interactive graphics

Traditionally, interactive applications have been difficult to build, modify and extend. These integrated applications provide bounded bounded functionality, have a single thread of control and a fixed user interface that must anticipate everything the user will need.Current workstations allow several processes to share the screen. With proper communication between processes, it is possible to escape previous models for application development and evolution.ConMan is a high-level visual language we use on an IRIS workstation that lets users dynamically build and modify graphics applications. To do this, a system designer disintegrates complex applications into modular components. By interactively connecting simple components, the user constructs a complete graphics application that matches the needs of a task. A connection manager controls the flow of data between individual components. As a result, we replace the usual user-machine dialog with a dynamic live performance that is orchestrated by the user.
The demographics of academic entitlement in grading

Within academia few constructs are so often talked about yet so poorly understood as academic entitlement. Using AE scales, this study evaluates the latent variables of AE in grading as well as the relationship of these factors to demographic variables including gender, nationality, and age. Using a factor analysis, three latent variables were found including effort expectancy (EE), academic sociopathy (AS), and negotiation (Ne). Analysis revealed reliable relationships between these factors and the demographic variables. These results suggest trends in the level and type of AE based on gender, age and ethnic identity, therefore, it may be possible to combat AE conflict with awareness of expectations and communication about rights and responsibilities of the student and instructor.
Survivals of Turkish Characteristics in Romanian Musica Lautareasca

Turkish political influence in Romania from the 16th Century until 1881 is well documented. Historical records also provide numerous references to Turkish music in Romania, which together with certain survivals in the form of instruments and musical forms serve to delineate the broader outlines of the potential area of influence of Turkish music on certain Romanian musical practices. In this presentation I shall attempt to gather together some of the surviving historical evidence for Turkish influence in Romania and subsequently to describe some previously undocumented surviving musical practices.
From teleteaching to teleaccreditation

SummaryInitial training and continuing medical education (CME) of high quality are the foundations of quality patient care. This obvious statement can be applied to all medical care and specialities, but is mandatory in those specialities with recurrent technological improvements, e.g. laparoscopic surgery. Verified indications and possible fields of use for laparoscopic surgery have extended to cover a nearly complete range of open surgical procedures, creating an important demand for teaching and training. Established practical training after initial competence verification should be the goal of all surgical training institutions, but the fact that access to training is still limited demands new solutions using telecommunication, especially in those countries rapidly introducing accreditation procedures.
The role of AIMP3, a putative tumour suppressor gene, as a predictive biomarker of response to chemo/radiotherapy in vitro and in patients with muscle-invasive bladder cancer.

Bladder cancer is the second most common urological cancer after prostate cancer and is one of the leading causes of cancer mortality in most western countries. For organ-confined, muscle-invasive disease, the standard of care, in terms of definitive cure, remains radical surgery (cystectomy) with lymphadenectomy. However, survival rates remain poor following supposedly curative treatment. Radical radiotherapy and more recently, multimodality treatment incorporating chemo-radiotherapy, are alternatives which allow bladder preservation in those choosing not to undergo or are unsuitable for radical surgery. However, survival rates following radiotherapy are generally lower relative to radical cystectomy and multimodality treatments can only be offered to select cases in few institutions. Biomarkers which can accurately predict tumour response to radiotherapy or chemotherapy can aid the selection of patients who are likely to respond well to treatment options incorporating radiotherapy and/or chemotherapy, as alternatives to radical cystectomy, in the management of bladder cancer. Such a strategy would allow personalised cancer care with patients likely to benefit from treatments that they are likely to respond well to and concomitantly avoid complications arising from other treatments less likely to benefit them. This thesis investigated the novel tumour suppressor gene, AIMP3 which is involved in the DNA damage response (DDR) pathway following exposure to genotoxic insults such as irradiation and chemotherapy. The expression and cellular localisation of AIMP3 protein was characterised in a panel of bladder cancer cell lines. Expression of AIMP3 was altered by gene knockdown with siRNA transfection and survival outcomes assessed following irradiation and chemotherapy. The predictive value of AIMP3 expression in determining survival outcome of patients with muscle-invasive bladder cancer who had undergone radical radiotherapy, with or without carbogen supplementation, in the BCON trial, was assessed. Prognostic significance was evaluated by interrogating a control cohort of patients who had undergone radical cystectomy and had not had exposure to radiotherapy or either neoadjuvant or adjuvant chemotherapy. Reportedly important DDR proteins, including Mre11, p53 and ERCC1, were also interrogated in the BCON, Radical Cystectomy, Neodjuvant and LaMB trial TMA datasets. Clonogenic survival outcomes following AIMP3 knockdown were also investigated in cisplatin-sensitive (RT112) and cisplatin-resistant (RT112CP) cell lines following cisplatin exposure. Survival outcome, stratified for AIMP3 as well as ERCC1, Mre11 and p53 status, were interrogated in the Neoadjuvant set, which incorporated a cohort of patients who had undergone cisplatin-based neoadjuvant chemotherapy prior to radical treatment. This was validated in a second cohort of patients who had undergone cisplatin-based chemotherapy as part of the LaMB trial.
Propofol-Associated Priapism in a Pediatric Patient

Objective: To report a case of priapism in an adolescent male following the use of propofol for sedation. Case Report: A 13-year-old male with developmental delay was admitted to intensive care secondary to pneumonia and persistent paroxysmal choreoathetosis. In attempt to stop the choreoathetosis and progressive rhabdomyolysis, he was sedated with 50 mg of intravenous propofol, which successfully resolved the choreoathetosis. Within minutes after the injection, he developed priapism, and within 1 hour it resolved without intervention. Discussion: Priapism was considered to be caused by propofol based on temporal relationship, lack of other medications administered, and complete resolution of symptoms after withdrawal. An objective causality assessment based on the Naranjo adverse drug reaction probability scale suggests propofol is a probable cause of the priapism in our patient. The mechanism of propofol-induced priapism is unknown but likely occurs due to both local and systemic effects. Conclusion: Pediatric clinicians should be aware of this rare side effect, as it requires prompt recognition and potential urologic intervention to alleviate complications.
Implementation by cultural infusion: an approach for managing the introduction of information technologies

This article describes an approach for managing the introduction of information technologies in organizations which we have called "implementation by cultural infusion. " The approach was developed and successfully used in response to the necessity of setting up a low-overhead, high-growth computer services function for a small research organization of about 200 nontechnical users. The article first describes how the organization established the infrastructural mechanisms to make such an implementation method successful. It then describes the concepts and dynamics of the cultural infusion approach to implementing information technologies, how it was used in the organization, what successes and failures were encountered, and what the impacts were after four years. Finally, the possibility of using the cultural infusion approach in larger organizations and different settings is examined.
Eficácia de dinoprostone e misoprostol para indução do trabalho de parto em nulíparas

PURPOSE: to determine the efficacy and safety of dinoprostone and misoprostol for the induction of vaginal childbirth, with or without the use of oxytocin in nulliparous women. METHODS: in this retrospective observational study, 238 patients were subjected to the induction of delivery from January 2008 to February 2010 with the use of misoprostol 25 mcg by the vaginal route or a pessary containing 10 mg of dinoprostone. A total of 184 patients were selected, with the following characteristics: nulliparous, gestational age of 37-42 weeks, singleton pregnancies, cephalic presentation, intact membranes, and Bishop score < 3. Obstetric and neonatal data were analyzed and compared between groups. The Student t-test, chi-square test and Fisher's exact test were used for statistical analysis, with the level of significance set at p<0.05. RESULTS: the rate of vaginal childbirth did not differ significantly in patients who used misoprostol and dinoprostone (43.2% versus 50%; p = 0.35, respectively). The ripening of cervix was higher in the group treated with misoprostol (87.3% versus 75.6%, p=0.04). The use of oxytocin was necessary in 58.8% of the misoprostol group and 57.3% in the dinoprostone group after the ripening of cervix. Failed induction was the primary indication of caesarean section delivery in both groups, with no significant difference between them. Fetal and maternal adverse events, such as tachysystole and Apgar scores were similar. CONCLUSION: dinoprostone and misoprostol are both effective for vaginal childbirth induction, although they need to be combined with oxytocin. They showed a similar safety profile, with misoprostol being more efficient regarding cervical ripening.
Extended Principal Orthogonal Decomposition Method for Cancer Screening

Abstract—Recent advances in microarray technology offer the ability to study the expression of thousands of genes simultaneously. The DNA data stored on these microarray chips can provide crucial information for early clinical cancer diagnosis. The Principal Orthogonal Decomposition (POD) method has been widely used as an effective feature detection method. In this paper, we present an enhancement to the standard approach of using the POD technique as a disease detection tool. In the standard method, cancer diagnosis of an arbitrary sample is based on its correlation value with the cancerous or normal signature extracted using the POD method from DNA microarray data. In this paper, we extend the POD method by feeding the extracted principal features into Machine Learning algorithms to detect cancer. Particularly, Linear Support Vector Machine, Feed Forward Back Propagation Networks, and Self-Organizing Maps are used on liver cancer, colon cancer, and leukemia data. Sensitivity, specificity, and accuracy are discussed to evaluate predictive abilities of the proposed extended POD methods. Our results indicate overall the proposed methods provide improvements over the standard POD method.
Statistical Review for Medical Journals, Journal's Perspective

Medical journals have moved away from case reports toward accounts of research studies, particularly randomized trials and epidemiologic studies, and statisticians have become central to medical journals and medical practice. They have played an important part in the move from opinion to evidence-based medicine. The author is Editor of the British Medical Journal and describes the contributions of statisticians to that journal's reviewing process: they are included in the team taking the final decision on whether to publish a paper. The article contains recommendations for policy on statistical review. Keywords: British Medical Journal; evidence-based
The Adventure of Working Abroad: Hero Tales from the Global Frontier

1. From Innocence to Mastery: Expatriate Stories and the Myth of the Hero's Journey 2. The Call to Adventure: Accepting the Challenge 3. The Belly of the Whale: Stepping into an Unknown World 4. The Magical FriAnd: Discovering a Cultural Mentor 5. The Road of Trials: Learning to Live with Paradox 6. The Ultimate Boon: Transforming and Enriching Ourselves 7. The Return: Making Meaning of the Experience 8. Appreciating the Journey: How Companies Can Support and Learn from Expatriate Successes AppAndix: Report on the Study of Returned Expatriates.
Estrategias de control para sistemas de generación distribuida durante huecos de tensión

The objective of this thesis is the development of control strategies for distributed generation systems during voltage sags. The proposed control strategies present different options to improve the behavior of inverters during voltage unbalances and grid faults. Therefore, it could be possible to contribute to ride-through the perturbation and to avoid the disconnection of power suppliers during these contingencies. The scope of the proposed strategies covers a wide range of possibilities, from static voltage unbalance to dynamic voltage sags. The control algorithms are versatile and their usefulness is discussed in detail. The utility of these algorithms is focused on distributed generation in power networks with high penetration of renewables energy sources, mainly wind farms, located in remote zones and connected in weak grids. The proposed control strategies are: (i). Voltage support control of the maximum and minimum phase voltages within the limits for continuous operation. (ii). Control of positive and negative active and reactive powers to flexibilize the low-voltage ridethrough services, by injecting the maximum current of the inverter. (iii). On the use of effective power factor for reducing the voltage unbalance in static grid voltage perturbations. El objetivo de esta tesis es el desarrollo de estrategias de control para sistemas de generación distribuida durante huecos de tensión. Las estrategias de control propuestas presentan diferentes alternativas para mejorar el comportamiento de los inversores durante desbalanceos y fallos de red. De esta forma, es posible contribuir a la superación de la perturbación y evitar la desconexión de los sistemas de potencia ante este tipo de contingencias. El ámbito de aplicación de las estrategias propuestas cubre un gran abanico de posibilidades, desde desbalanceos de tensión estáticos hasta huecos de tensión dinámicos. Los algoritmos de control son versátiles y su aplicabilidad es discutida en detalle. La utilidad de estos algoritmos está enfocada hacia sistemas de generación distribuida en redes eléctricas con gran integración de renovables, principalmente eólica, ubicados en zonas remotas y conectados a una red blanda. Las estrategias de control presentadas son (i). Control para el soporte de tensión máxima y mínima dentro de los límites para la operación continua. (ii). Control de potencias activa y reactiva de secuencia positiva y negativa para flexibilizar los servicios durante huecos de tensión, inyectando el máximo de corriente permitida por el inversor. (iii). Alternativas para la utilización del factor de potencia efectivo para reducir el desbalanceo en perturbaciones estáticas de tensión.
A Comparison of Drug Concentrations in Postmortem Cardiac and Peripheral Blood in 320 Cases

ABSTRACTFor many years it has become increasingly apparent from literature reports that the postmortem cardiac blood concentrations of certain drugs can be significantly different than those found in peripheral blood.The cardiac to peripheral ratio (C/P) of drug concentrations in postmortem blood samples was determined for 113 drugs representing toxicological findings in 320 cases. Theories postulated in current scientific literature to explain observed site dependence of drug concentration in postmortem blood are discussed in light of the findings.It is suggested that drug quantifications be done on both cardiac and peripheral blood and that the final interpretation of results be done as a team effort by all individuals involved in the death investigation.
Long-range dismount activity classification: LODAC

Continuous classification of dismount types (including gender, age, ethnicity) and their activities (such as walking, running) evolving over space and time is challenging. Limited sensor resolution (often exacerbated as a function of platform standoff distance) and clutter from shadows in dense target environments, unfavorable environmental conditions, and the normal properties of real data all contribute to the challenge. The unique and innovative aspect of our approach is a synthesis of multimodal signal processing with incremental non‐parametric, hierarchical Bayesian machine learning methods to create a new kind of target classification architecture. This architecture is designed from the ground up to optimally exploit correlations among the multiple sensing modalities (multimodal data fusion) and rapidly and continuously learns (online self‐tuning) patterns of distinct classes of dismounts given little a priori information. This increases classification performance in the presence of challenges posed by anti‐access/area denial (A2/AD) sensing. To fuse multimodal features, Long-range Dismount Activity Classification (LODAC) develops a novel statistical information theoretic approach for multimodal data fusion that jointly models multimodal data (i.e., a probabilistic model for cross‐modal signal generation) and discovers the critical cross‐modal correlations by identifying components (features) with maximal mutual information (MI) which is efficiently estimated using non‐parametric entropy models. LODAC develops a generic probabilistic pattern learning and classification framework based on a new class of hierarchical Bayesian learning algorithms for efficiently discovering recurring patterns (classes of dismounts) in multiple simultaneous time series (sensor modalities) at multiple levels of feature granularity.
Molecular half-full mechanisms by phagocityc cells on invasive Aspergilosis

Los hongos del genero Aspergillus afectan sobre todo al tejido pulmonar, presentandose cuando la integridad del sistema inmune del hospedero se ve comprometida. El organismo en condiciones de inmunocompetencia se vale para controlar la infeccion tanto de defensas mecanicas, enzimas y la accion de celulas del sistema inmune innato y respuestas adaptativas. Los neutrofilos, macrofagos y celulas dendriticas son de fundamental importancia como celulas efectoras antifungicas, poseen receptores de superficie como TLR, Dectina-1, DC-SIGN y receptor de manosa (MR) que reconocen estructuras micoticas y desencadenan respuestas especificas. TLR y Dectina-1, son los mas estudiados para esta interaccion. Los TLR son los responsables de la produccion y liberacion de citocinas y Dectina- 1 es fundamental en la fagocitosis de la particula reconocida y la produccion de ROS. DC-SIGN es el receptor esencial para el reconocimiento de las esporas de Aspergillus spp. por celulas dendriticas y macrofagos, y se encuentra presente en celulas pulmonares con actividad fagocitica. El MR reconoce estructuras micoticas despues de la internalizacion del hongo y promueve la liberacion de una amplia variedad de citocinas. Las citocinas mejor estudiadas y cuyo papel es crucial en la respuesta contra Aspergillus spp. son TNF-α, IFN-γ e IL-12. En el presente trabajo, se revisaron los principales mecanismos moleculares relacionados con los receptores presentes en las celulas fagociticas implicadas en el reconocimiento de Aspergillus spp. La comprension de la respuesta inmune en situaciones de inmunocompetencia y su comparacion en organismos inmunodeficientes podria proporcionar alternativas que permitan el control de la aspergilosis invasiva