Miracle-dz/UniFAR-FTUs huggingface dataset:
Foraging strategy mediates ectotherm predator-prey responses to climate warming.

Climate warming and species traits interact to influence predator performance, including individual feeding and growth rates. However, the effects of an important trait-predator foraging strategy-are largely unknown. We investigated the interactions between predator foraging strategy and temperature on two ectotherm predators: an active predator, the backswimmer Notonecta undulata, and a sit-and-wait predator, the damselfly Enallagma annexum. In a series of predator-prey experiments across a temperature gradient, we measured predator feeding rates on an active prey species, zooplankton Daphnia pulex, predator growth rates, and mechanisms that influence predator feeding: body speed of predators and prey (here measured as swimming speed), prey encounter rates, capture success, attack rates, and handling time. Overall, warming led to increased feeding rates for both predators through changes to each component of the predator's functional response. We found that prey swimming speed strongly increased with temperature. The active predator's swimming speed also increased with temperature, and together, the increase in predator and prey swimming speed resulted in two-fold higher prey encounter rates for the active predator at warmer temperatures. By contrast, prey encounter rates of the sit-and-wait predator increased four-fold with rising temperatures as a result of increased prey swimming speed. Concurrently, increased prey swimming speed was associated with a decline in the active predator's capture success at high temperatures, whereas the sit-and-wait predator's capture success slightly increased with temperature. We provide some of the first evidence that foraging traits mediate the indirect effects of warming on predator performance. Understanding how traits influence species' responses to warming could clarify how climate change will affect entire functional groups of species.
Revisit, Reform, and Redesign: A Novel Dissection Approach for Demonstrating Anatomy of the Orbit for Continuing Professional Development Education

Advanced postgraduate medical education for health‐care professionals is constantly evolving. Understanding facial anatomy and especially its vascular system is crucial when performing soft tissue filler injections to avoid adverse events including tissue loss or irreversible blindness. Standard anatomical resources often fall short of elucidating clinically relevant concepts in more highly specialized areas of interest. A novel dissection approach for demonstrating the anatomy of the lateral orbit was presented at scientific meetings to participants from dermatology, plastic surgery, and general practice. Results from the post‐course online survey (n = 52) were analyzed. The results of the survey reveal a high educational impact and a high clinical relevance of the novel dissection approach. In addition, the majority of respondents (97.7%; n = 51) felt that the exposed anatomical structure of the orbit and face improved their ability to safely perform cosmetic procedures on the face. More experienced respondents who had previously attended at least five cadaveric dissections were more likely to strongly agree that reviewing anatomy through this novel dissection approach increased their confidence in avoiding periorbital vascular danger zones. As minimally invasive outpatient procedures continue to evolve, practicing physicians and mid‐level providers often face the challenge of having to reconcile preexisting anatomical knowledge with new clinical practice. Skills required to navigate high impact anatomy include visualization of structures that form the navigational landscape and avoidance of key danger zones. The novel dissection approach to the lateral orbit reflects the increasing focus on revisiting, reforming, and redesigning anatomy for continuing professional development activities.
Food Insecurity and Insulin Use in Hyperglycemic Patients Presenting to the Emergency Department

Introduction The prevalence of food insecurity (FI) and insulin rationing among patients with diabetes who present to the emergency department (ED) is unclear. We examined the prevalence of food insecurity and subtherapeutic insulin use among patients who presented to the ED with a blood glucose level of greater than 250 milligrams per deciliter. Methods This was a single-center, cross-sectional survey of clinically stable, hyperglycemic adults in the ED for food insecurity using the Hunger Vital Sign screening tool. Patients who were insulin dependent were asked about insulin usage and rationing. Results Of the 85 eligible patients, 76 (89.4%) were enrolled; 35 (46%) screened positive for food insecurity. Food insecure patients were 1.9 times more likely to be hospitalized than non-food insecure patients (relative risk = 1.90 [1.21–2.99], p<.01). Food insecure patients were younger than non-food insecure patients (50.4 vs 57.5 p<.02), and had significantly higher hemoglobin A1c (HgbA1c) levels (11.2% vs 9.9% p = 0.04). Of the 49 patients prescribed insulin, 17 (34.6%) stated they had used less insulin during the prior week than had been prescribed, and 21 (42.9%) stated they had used less insulin during the prior year than had been prescribed. Food insecure patients were more likely to have used less insulin than prescribed in the prior year (odds ratio = 3.60 [1.09–11.9], p = 0.04). Conclusion Our exploratory findings suggest almost half of clinically stable adults presenting to our inner-city ED with hyperglycemia experience food insecurity. More than one-third of those prescribed insulin used less than their prescribed amount in the prior year.
Development and progress of clinical trials of Coronavirus Disease 2019 antiviral drugs

ABSTRACT Introduction We have summarized and analyzed the clinical trial registration status and the latest research progress of eight major antiviral drugs during the epidemic of Coronavirus Disease 2019 (COVID-19), which can provide reference methods for clinical formulation of the best antiviral treatment. Areas covered We used the generic names of 8 antiviral drugs as keywords to search and analyze the COVID-19-related clinical trials registered in Chinese Clinical Trial Registry and ClinicalTrials.gov. Then, we used the keywords to obtain and summarize their clinical research results related to COVID-19 in CNKI, WANFANG, CQVIP, and PubMed database. Expert opinion The registration system of clinical trials and the level of clinical trial design need to be further improved. At present, no specific drug has been found for the treatment of COVID-19, the efficacy of antiviral drugs mostly comes from small sample studies or retrospective studies, and the level of clinical evidence is low. Besides, multi-drug combination therapy may become a more effective treatment choice, but the drug interactions and adverse drug reactions also need to be closely monitored. In summary, the safety and efficacy of various antiviral drugs need to be confirmed by large samples and high-quality RCT studies.
Interplay between SARS-CoV-2 and the type I interferon response

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. An unbalanced immune response, characterized by a weak production of type I interferons (IFN-Is) and an exacerbated release of proinflammatory cytokines, contributes to the severe forms of the disease. SARS-CoV-2 is genetically related to SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS-CoV), which caused outbreaks in 2003 and 2013, respectively. Although IFN treatment gave some encouraging results against SARS-CoV and MERS-CoV in animal models, its potential as a therapeutic against COVID-19 awaits validation. Here, we describe our current knowledge of the complex interplay between SARS-CoV-2 infection and the IFN system, highlighting some of the gaps that need to be filled for a better understanding of the underlying molecular mechanisms. In addition to the conserved IFN evasion strategies that are likely shared with SARS-CoV and MERS-CoV, novel counteraction mechanisms are being discovered in SARS-CoV-2–infected cells. Since the last coronavirus epidemic, we have made considerable progress in understanding the IFN-I response, including its spatiotemporal regulation and the prominent role of plasmacytoid dendritic cells (pDCs), which are the main IFN-I–producing cells. While awaiting the results of the many clinical trials that are evaluating the efficacy of IFN-I alone or in combination with antiviral molecules, we discuss the potential benefits of a well-timed IFN-I treatment and propose strategies to boost pDC-mediated IFN responses during the early stages of viral infection.
Phase integration bias in a motion grouping task

The perception of the direction of global motion depends on our ability to integrate local motion signals over space and time. We examined motion binding using a task requiring integration of relative phase. Observers completed multiple tasks involving clockwise and counter clockwise motion in a stimulus comprising four sets of linearly arranged dots, two moving horizontally and two moving vertically along sinusoidal trajectories differing in phase. Noise jitter was added along the trajectory perpendicular to each dot's motion. The noise acts as a global grouping cue that improves direction discrimination, but surprisingly, the absence of noise causes consistent below-chance performance (Lorenceau, 1996). We explore this phenomenon and subsequently test the hypothesis that observers perceive reverse motion because their representation of the relative phase of the motion components is systematically biased. We employ a number of different objective and subjective measures of motion integration and measure the phenomenon in both younger and older adults. Taken together, the results presented in the current article demonstrate that noise can promote global grouping in the stimulus and that confident, incorrect responses can be observed in the absence of correct global grouping. Generally, the current result raises the possibility that an integration bias could exist in other motion tasks.
Effect of Searing Process on Quality Characteristics and Storage Stability of Sous-Vide Cooked Pork Patties

This study investigated the effects of searing process before sous-vide (SV) treatment on quality traits, visual attributes, palatability, and storage stability of SV cooked pork patties. Patties were seared on each side by pan-frying for 0 (control), 30 (S30), 60 (S60), 90 (S90), or 120 (S120) s in a stainless-steel pan, and all patties were then vacuum-packed and cooked under thermally controlled conditions at 75 °C for 2 h. Marked differences were observed in quality properties between the control and searing groups, and the S120 group exhibited greater brown surface color and cooking loss compared to the other groups (p < 0.001) due to the additional heating process. Patties from the S60 group showed greater appearance and tenderness acceptability scores compared to patties from the S30 and S120 groups (p < 0.001). On another note, the effects of searing on storage stability were somewhat limited, as they were measured by 2-thiobarbituric acid reactive substance, volatile basic nitrogen, total aerobic bacterial count, and coliforms during 49 d of cold storage. Therefore, searing process before SV treatment can improve the visual attributes and palatability of cooked pork patties, and the optimum searing condition was for 60 s, without impairing the storage stability.
Variation of Bending Capacity Along the Lamina Length of a Grass, Imperata cylindrica var. major (Gramineae)

The aim of this paper is to investigate variation of the bending moment capacity along the lamina of a grass (Imperata cylindrica (L.) Raeusch. var. major (Nees) C. E.Hubb. ex C. E.Hubb. & Vaughan). It is postulated that the bending strength of the grass section is obtained predominantly from the midrib and that the grass lamina contributes little to the overall bending behaviour. By observing transverse sections of the midrib, it can be estimated that the thickness of the outer sclerenchyma zone is approx. 10% of the midrib diameter and that the pith parenchyma makes up most of the rest of the midrib. This observation is taken to be valid for the entire length of the lamina. A simple structural model of an elliptical tube is proposed for the midrib. Bending tests on the grass lamina have shown that the bending moment capacity is very low in the distal third, but increases linearly in the middle third and is generally constant in the proximal third. Using the structural model for the midrib, the results indicate that the maximum bending stress of the midrib remains fairly constant over the length of the grass. # 1999 Annals of Botany Company
When Road Information Meets Data Mining: Precision Detection for Heading and Width of Roads

Real-time road information plays a crucial role in enabling intelligent transportation systems (ITS) applications. With sufficient road information, the map of road topography can be built and updated more easily. Furthermore, many appealing ITS applications can be enabled accordingly. Aiming at improving the quality and update rate of road information, a hot topic today is how to mine information from global positioning systems (GPS) trajectories by the clustering-based methods. Such schemes, however, encounter two challenges: 1) GPS noise and 2) low sampling rate of GPS traces data. As a result, it is difficult to infer road information from these irregular clusters. To tackle the above issues, we directly mine useful road information, heading, and width of roads, for ITS applications from GPS point cloud, i.e., a set of GPS points. First, the distribution of GPS points is discussed and the least squares method (LSM) is demonstrated to be outstanding for mining the heading of the road under a huge number of GPS points. Second, the weighted approximation least squares method is proposed to improve the accuracy of the LSM. Furthermore, combining with relevant distribution features in GPS points, the data distribution variance-road width discrete model is proposed to mine road width from GPS point cloud. Finally, using real-world datasets, we demonstrate that these proposed methods can achieve satisfactory performance in practice.
RHEOLOGICAL AND SENSORY PROPERTIES OF POPULAR GREEK FOODSTUFFS: A REVIEW

The rheological and sensory properties that constitute the quality benchmark of Greek foodstuffs are identified in a critical fashion and prevailing practices are discussed in relation to home-made and industrial production. Formulation modifications aimed at enhancing the appeal of products in terms of organoleptic characteristics and nutritional impact are also presented. Olive oil occupies an important position in the Greek diet and it is characterised by a unique flavour. Accurate determination of flavour is carried out using the sensory wheel, which unveils the grade of the product. Among foods with soft-solid characteristics, traditional Feta cheese has a prominent place and it is well known for a salty, slightly acidic taste. Ageing within a year results in textural changes from a soft and elastic consistency to a hard and brittle body. Full and low fat Greek yoghurts are consumed widely locally and abroad. The mouthfeel of the product changes from that of a week gel to a viscous fluid at a fat content of 10% and 2%, respectively. Finally, emulsion-type products range from commercial salamis to traditional sausages, which satisfy culinary requirements for a ‘rubbery' or ‘spreadable' texture depending on the favourite pastime dinner. It is hoped that the treatise will unveil the appetising features of Greek foodstuffs, which are increasingly recognised by the international consumer.
Therapeutic promises of leukocyte elastase and macrophage metalloelastase inhibitors for the treatment of pulmonary emphysema

The fibrous protein elastin, which comprises an appreciable percentage of all protein content in some tissues, such as arteries, some ligaments, and the lungs, can be hydrolysed or otherwise destroyed by a select group of enzymes classified as elastases. To date four elastases are known, three of which are human: human leukocyte elastase (HLE), pancreatic elastase II (PE-II) and macrophage metalloelastase (MME, MMP-12). Human leukocyte and pancreatic elastases are both serine proteinases (i.e., having a catalytic triad corresponding to Ser195, Asp102 and His57 of chymotrypsin). However, macrophage metalloelastase is a member of the matrix metalloproteinase family (MMPs, matrixins), which contain a zinc atom at the catalytic site. Imbalances in the levels or regulation of tissue or cellular proteases are thought to manifest themselves in various disease states. In order to prevent self-inflicted tissue damage due to over expression of enzymes, numerous endogenous inhibitors directed against proteolytic enz.
Loss of Heterozygosity and Base Mutation Rates Vary Among Saccharomyces cerevisiae Hybrid Strains

A growing body of evidence suggests that mutation rates exhibit intra-species specific variation. We estimated genome-wide loss of heterozygosity (LOH), gross chromosomal changes, and single nucleotide mutation rates to determine intra-species specific differences in hybrid and homozygous strains of Saccharomyces cerevisiae. The mutation accumulation lines of the S. cerevisiae hybrid backgrounds - S288c/YJM789 (S/Y) and S288c/RM11-1a (S/R) were analyzed along with the homozygous diploids RM11, S288c, and YJM145. LOH was extensive in both S/Y and S/R hybrid backgrounds. The S/Y background also showed longer LOH tracts, gross chromosomal changes, and aneuploidy. Short copy number aberrations were observed in the S/R background. LOH data from the S/Y and S/R hybrids were used to construct a LOH map for S288c to identify hotspots. Further, we observe up to a sixfold difference in single nucleotide mutation rates among the S. cerevisiae S/Y and S/R genetic backgrounds. Our results demonstrate LOH is common during mitotic divisions in S. cerevisiae hybrids and also highlight genome-wide differences in LOH patterns and rates of single nucleotide mutations between commonly used S. cerevisiae hybrid genetic backgrounds.
Ginseng-Induced Changes to Blood Vessel Dilation and the Metabolome of Rats

Ginseng consumption has been shown to prevent and reduce many health risks, including cardiovascular disease. However, the ginseng-induced changes in biofluids and tissue metabolomes associated with blood health remain poorly understood. In this study, healthy rats were orally administered ginseng extracts or water for one month. Biofluid and tissue metabolites along with steroid hormones, plasma cytokines, and blood pressure factors were determined to elucidate the relationship between ginseng intake and blood vessel health. Moreover, the effect of ginseng extract on blood vessel tension was measured from the thoracic aorta. Ginseng intake decreased the levels of blood phospholipids, lysophosphatidylcholines and related enzymes, high blood pressure factors, and cytokines, and induced vasodilation. Moreover, ginseng intake decreased the level of renal oxidized glutathione. Overall, our findings suggest that ginseng intake can improve blood vessel health via modulation of vasodilation, oxidation stress, and pro-inflammatory cytokines. Moreover, the decrease in renal oxidized glutathione indicated that ginseng intake is positively related with the reduction in oxidative stress-induced renal dysfunction.
Influence of neural mobilization in the sympathetic slump position on the behavior of the autonomic nervous system

Introduction: The neural mobilization technique in the sympathetic slump position (NMSS) was based on the slump test, whose purpose was to directly influence the sympathetic trunk and thus provide greater analgesia by sympathetic activation and treat pain syndromes caused by peripheral sympathetic changes. Therefore, as the autonomic nervous system (ANS) is responsible for extrinsic regulation of the cardiovascular system through sympathetic and parasympathetic action, the aim of this study was to investigate the influence of the NMSS technique on the systolic and diastolic blood pressure and heart rate variability in athlete and non-athlete men. Methods: Twenty-eight subjects performed the procedure that was divided into three phases: rest; intervention and recovery, lasting 4 minutes and 30 seconds each, totaling a 13-minute and 30 seconds collection time. Results: The results showed that the NMSS technique significantly influences the action/activity of the ANS, as there was predominant sympathetic activation during the application of the technique, which was observed by the increase in systolic blood pressure, low frequency (LF), LF/HF ratio and decreased values of high frequency (HF). Conclusion: It may be concluded that the neural mobilization technique on the sympathetic slump (NMSS) significantly influences the ANS action/activity. Among the groups there was no statistically significant difference in heart rate variability. It is worth noting that patients with cardiovascular disorders may be at risk if the NMSS technique is applied, since there was an increase in SBP and sympathetic activation during its application in both groups.
Melatonin as a Radio-Sensitizer in Cancer

Radiotherapy is one of the treatments of choice in many types of cancer. Adjuvant treatments to radiotherapy try, on one hand, to enhance the response of tumor cells to radiation and, on the other hand, to reduce the side effects to normal cells. Radiosensitizers are agents that increase the effect of radiation in tumor cells by trying not to increase side effects in normal tissues. Melatonin is a hormone produced mainly by the pineal gland which has an important role in the regulation of cancer growth, especially in hormone-dependent mammary tumors. Different studies have showed that melatonin administered with radiotherapy is able to enhance its therapeutic effects and can protect normal cells against side effects of this treatment. Several mechanisms are involved in the radiosensitization induced by melatonin: increase of reactive oxygen species production, modulation of proteins involved in estrogen biosynthesis, impairment of tumor cells to DNA repair, modulation of angiogenesis, abolition of inflammation, induction of apoptosis, stimulation of preadipocytes differentiation and modulation of metabolism. At this moment, there are very few clinical trials that study the therapeutic usefulness to associate melatonin and radiotherapy in humans. All findings point to melatonin as an effective adjuvant molecule to radiotherapy in cancer treatment.
Object identity determines trans-saccadic integration

Humans make two to four rapid eye movements (saccades) per second, which, surprisingly, does not lead to abrupt changes in vision. To the contrary, we perceive a stable world. Hence, an important question is how information is integrated across saccades. To investigate this question, we used the sequential metacontrast paradigm (SQM), where two expanding streams of lines are presented. When one line is spatially offset, the other lines are perceived as being offset, too. When more lines are offset, all offsets integrate mandatorily; that is, observers cannot report the individual offsets but perceive one integrated offset. Here, we asked observers to make a saccade during the SQM. Even though the saccades caused a highly disrupted motion trajectory on the retina, offsets presented before and after the saccade integrated mandatorily. When observers made no saccade and the streams were displaced on the screen so that a similarly disrupted retinal image occurred as in the previous condition, no integration occurred. We suggest that trans-saccadic integration and perception are determined by object identity in spatiotopic coordinates and not by the retinal image.