Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between Childhood Suicidal Ideation and Geriatric Depression in Japan: A Population-Based Cross-Sectional Study

Adverse childhood experiences (ACEs) are assumed to increase the risk of depression in late life via development of poor mental health conditions; however, the association between mental distress in childhood and geriatric depression has not been directly examined. This study examined the association between childhood suicidal ideation and geriatric depression, using population-based, cross-sectional survey data from 1140 community-dwelling, functionally independent older adults in Wakuya City, Japan. We assessed childhood suicidal ideation by asking the participants whether they had seriously considered attempting suicide before the age of 18, together with geriatric depression, using the Japanese version of the 15-item Geriatric Depression Scale. Poisson regression was applied to adjust for potential confounders and mediators. In total, 6.1% of the participants reported childhood suicidal ideation. After adjustment for sex, age, personality attributes and ACEs, childhood suicidal ideation was positively associated with geriatric depression prevalence ratio [PR]: 1.40, 95% Confidence Interval (95%CI): 1.04–1.88). The increased PR of geriatric depression remained significant, even after further adjustment for adulthood socio-economic status, recent life stressors and current health status (PR: 1.38, 95%CI: 1.02–1.88). Further prospective studies are warranted, but efforts to deliver mental health services to children with suicidal ideation potentially diminish the highly prevalent geriatric depression.
Heissiella donguri sp. nov. (Hemiptera: Heteroptera: Tingidae) feeding on Quercus gilva (Fagaceae): First representative of the genus from Japan.

The lace bug genus Heissiella Péricart, 1984 (Hemiptera: Heteroptera: Tingidae) is recorded from Japan for the first time, and a new species, which has been recorded as 'Tingis (Tropidocheila) sp. ' or 'Tingis (Tropidocheila) shaowuana Drake Maa, 1953' (misidentification) by previous authors, is described under the name of H. donguri sp. nov. This new species was found on the leaves of Quercus gilva Blume (Fagaceae) in the laurilignosa ecosystem of Honshu and Kyushu, extending the known distribution range of the genus into the Palaearctic Region. The distribution range and the host plant relationship of the new species are discussed. A key to all described species of the genus and a photograph of a living individual for the new species are also presented.
PEDOT:PSS-Based Conductive Textiles and Their Applications

The conductive polymer complex poly (3,4-ethylene dioxythiophene):polystyrene sulfonate (PEDOT:PSS) is the most explored conductive polymer for conductive textiles applications. Since PEDOT:PSS is readily available in water dispersion form, it is convenient for roll-to-roll processing which is compatible with the current textile processing applications. In this work, we have made a comprehensive review on the PEDOT:PSS-based conductive textiles, methods of application onto textiles and their applications. The conductivity of PEDOT:PSS can be enhanced by several orders of magnitude using processing agents. However, neat PEDOT:PSS lacks flexibility and strechability for wearable electronics applications. One way to improve the mechanical flexibility of conductive polymers is making a composite with commodity polymers such as polyurethane which have high flexibility and stretchability. The conductive polymer composites also increase attachment of the conductive polymer to the textile, thereby increasing durability to washing and mechanical actions. Pure PEDOT:PSS conductive fibers have been produced by solution spinning or electrospinning methods. Application of PEDOT:PSS can be carried out by polymerization of the monomer on the fabric, coating/dyeing and printing methods. PEDOT:PSS-based conductive textiles have been used for the development of sensors, actuators, antenna, interconnections, energy harvesting, and storage devices. In this review, the application methods of PEDOT:SS-based conductive polymers in/on to a textile substrate structure and their application thereof are discussed.
Dissociation proneness and pain hyposensitivity in current and remitted borderline personality disorder

Stress‐related dissociation has been shown to negatively co‐vary with pain perception in current borderline personality disorder (cBPD). While remission of the disorder (rBPD) is associated with normalized pain perception, it remains unclear whether dissociation proneness is still enhanced in this group and how this feature interacts with pain sensitivity.
Social Media Multidimensional Analysis for Intelligent Health Surveillance

Background: Recent work in social network analysis has shown the usefulness of analysing and predicting outcomes from user-generated data in the context of Public Health Surveillance (PHS). Most of the proposals have focused on dealing with static datasets gathered from social networks, which are processed and mined off-line. However, little work has been done on providing a general framework to analyse the highly dynamic data of social networks from a multidimensional perspective. In this paper, we claim that such a framework is crucial for including social data in PHS systems. Methods: We propose a dynamic multidimensional approach to deal with social data streams. In this approach, dynamic dimensions are continuously updated by applying unsupervised text mining methods. More specifically, we analyse the semantics and temporal patterns in posts for identifying relevant events, topics and users. We also define quality metrics to detect relevant user profiles. In this way, the incoming data can be further filtered to cope with the goals of PHS systems. Results: We have evaluated our approach over a long-term stream of Twitter. We show how the proposed quality metrics allow us to filter out the users that are out-of-domain as well as those with low quality in their messages. We also explain how specific user profiles can be identified through their descriptions. Finally, we illustrate how the proposed multidimensional model can be used to identify main events and topics, as well as to analyse their audience and impact. Conclusions: The results show that the proposed dynamic multidimensional model is able to identify relevant events and topics and analyse them from different perspectives, which is especially useful for PHS systems.
Naphthoquinones, benzoquinones, and anthraquinones: Molecular docking, ADME and inhibition studies on human serum paraoxonase-1 associated with cardiovascular diseases.

Paraoxonase-1 (PON1) has essential roles such as protecting low-density lipoprotein against detoxification and oxidation of highly toxic compounds. Quinones are a class of compounds and a type of plant-derived secondary metabolites. Here, PON1 was purified using very simple methods and evaluation of the interactions between the enzyme and some quinones. It was found that these quinones displayed effective inhibitor properties for PON1 with the IC50 values in the range of 3.27-82.90 μM and the K i values in the range of 2.50 ± 0.65 to 30.90 ± 7.20 μM. These quinones displayed distinct inhibition mechanisms. It was determined that except for 5-hydroxy-2-methyl-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone all quinones exhibit competitive inhibition effects. Also, molecular docking and in silico ADME studies were performed. Usage of drugs including quinone derivatives in structure with biological activity would be hazardous in some cases.
Quantity, Quality, and Performance of Corporate Social Responsibility Information Disclosure by Listed Enterprises in China: A Regional Perspective

The purpose of this article is to promote an increase in the number of enterprises that will disclose corporate social responsibility (CSR) information, and to improve on their quality of CSR information disclosure. Using the theory of organizational ecology, we propose that the density of companies that disclose CSR information in a region has an impact on both the quality and the performance of CSR disclosures. The study results suggest that an increase in the density of CSR information disclosing enterprises in a region will increase the number of enterprises with disclosure intentions. A density increase has a nonlinear influence on the quality of CSR information disclosure and on corporate performance, where the influence of disclosing enterprises’ density on corporate performance is partly mediated by the quality of CSR information disclosure. Our research also shows that the impact of density change of disclosing enterprises on the quality of CSR information disclosure is mediated by corporate capital structure.
Is Early Blindness Protective of Psychosis or Are We Turning a Blind Eye to the Lack of Statistical Power?

1Psychiatric Research Academy, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 2The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; 3Department of Ophthalmology, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 4Department of Affective Disorders, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 5The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH, Aarhus, Denmark; 6Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark
Prevention and Management of the Post-Thrombotic Syndrome

The post-thrombotic syndrome (PTS) is a form of chronic venous insufficiency secondary to prior deep vein thrombosis (DVT). It affects up to 50% of patients after proximal DVT. There is no effective treatment of established PTS and its management lies in its prevention after DVT. Optimal anticoagulation is key for PTS prevention. Among anticoagulants, low-molecular-weight heparins have anti-inflammatory properties, and have a particularly attractive profile. Elastic compression stockings (ECS) may be helpful for treating acute DVT symptoms but their benefits for PTS prevention are debated. Catheter-directed techniques reduce acute DVT symptoms and might reduce the risk of moderate–severe PTS in the long term in patients with ilio-femoral DVT at low risk of bleeding. Statins may decrease the risk of PTS, but current evidence is lacking. Treatment of PTS is based on the use of ECS and lifestyle measures such as leg elevation, weight loss and exercise. Venoactive medications may be helpful and research is ongoing. Interventional techniques to treat PTS should be reserved for highly selected patients with chronic iliac obstruction or greater saphenous vein reflux, but have not yet been assessed by robust clinical trials.
Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Although the established ELISA-based sensing platforms have many benefits, the importance of cytokine and cancer biomarkers detection for point-of-care diagnostics has propelled the search for more specific, sensitive, simple, accessible, yet economical sensor. Paper-based biosensor holds promise for future in-situ applications and can provide rapid analysis and data without the need to conduct in a laboratory. Electrochemical detection plays a vital role in interpreting results obtained from qualitative assessment to quantitative determination. In this review, various factors affecting the design of an electrochemical paper-based biosensor are highlighted and discussed in depth. Different detection methods, along with the latest development in utilizing them in cytokine and cancer biomarkers detection, are reviewed. Lastly, the fabrication of portable electrochemical paper-based biosensor is ideal in deliberating positive societal implications in developing countries with limited resources and accessibility to healthcare services.
MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis and hydrocephalus.

Hydrocephalus is characterized by abnormal accumulation of cerebrospinal fluid (CSF) in the ventricular cavity. The circulation of CSF in brain ventricles is controlled by the coordinated beating of motile cilia at the surface of ependymal cells (ECs). Here we show that MT1-MMP is highly expressed in olfactory bulb, rostral migratory stream, and ventricular system. Mice deficient for Membrane type-1-MMP (MT1-MMP) develop typical phenotypes observed in hydrocephalus such as dome-shaped skull, dilated ventricles, corpus callosum agenesis and astrocyte hypertrophy during the first two weeks of postnatal development. MT1-MMP deficient mice exhibits reduced and disorganized motile cilia with the impaired maturation of ECs, leading to abnormal CSF flow. Consistent with the defects in motile cilia morphogenesis, the expressions of pro-multiciliogenic genes are significantly decreased with a concomitant hyper-activation of Notch signaling in the wall of lateral ventricles in Mmp14-/- brains. Inhibition of Notch signaling by γ-secretase inhibitor restores ciliogenesis in Mmp14-/- ECs. Taken together, these data suggest that MT1-MMP is required for ciliogenesis and ependymal cell maturation by suppressing Notch signaling during early brain development. Our findings implicate that MT1-MMP is critical for early brain development and loss of MT1-MMP activity gives rise to hydrocephalus.
Contribution of Neurotrophins to the Immune System Regulation and Possible Connection to Alcohol Addiction

The first references to neurotrophic factors date back to the middle of the 20th century when the nerve growth factor (NGF) was first discovered. Later studies delivered a large amount of data on neurotrophic factors. However, many questions regarding neurotrophin signaling still remain unanswered. One of the principal topics in neurotrophin research is their role in the immune system regulation. Another important research question is the possible involvement of neurotrophin signaling in the pathological processes associated with alcoholism. Among known neurotrophins, NT-4 remains the least studied and appears to be involved in alcoholism and chronic stress pathogenesis. In this review we discuss known neurotrophin signaling cascades mediated by different neurotrophin receptors, as well as provide a generalization of the data regarding the influence of neurotrophins NGF, BDNF, and NT-4 on the immune system and their potential contribution to the pathogenesis of alcoholism.
Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism

Myelin is critical for the proper function of the nervous system and one of the most complex cell–cell interactions of the body. Myelination allows for the rapid conduction of action potentials along axonal fibers and provides physical and trophic support to neurons. Myelin contains a high content of lipids, and the formation of the myelin sheath requires high levels of fatty acid and lipid synthesis, together with uptake of extracellular fatty acids. Recent studies have further advanced our understanding of the metabolism and functions of myelin fatty acids and lipids. In this review, we present an overview of the basic biology of myelin lipids and recent insights on the regulation of fatty acid metabolism and functions in myelinating cells. In addition, this review may serve to provide a foundation for future research characterizing the role of fatty acids and lipids in myelin biology and metabolic disorders affecting the central and peripheral nervous system.
Evaluation of the heart and lung dosimetric parameters in deep inspiration breath hold using 3D Slicer

Purpose The present study was conducted to compare dosimetric parameters for the heart and left lung between free breathing (FB) and deep inspiration breath hold (DIBH) and determine the most important potential factors associated with increasing the lung dose for left-sided breast radiotherapy using image analysis with 3D Slicer software. Materials and Methods Computed tomography-simulation scans in FB and DIBH were obtained from 17 patients with left-sided breast cancer. After contouring, three-dimensional conformal plans were generated for them. The prescribed dose was 50 Gy to the clinical target volume. In addition to the dosimetric parameters, the irradiated volumes and both displacement magnitudes and vectors for the heart and left lung were assessed using 3D Slicer software. Results The average of the heart mean dose (Dmean) decreased from 5.97 to 3.83 Gy and V25 from 7.60% to 3.29% using DIBH (p < 0.001). Furthermore, the average of Dmean for the left lung was changed from 8.67 to 8.95 Gy (p = 0.389) and V20 from 14.84% to 15.44% (p = 0.387). Both of the absolute and relative irradiated heart volumes decreased from 42.12 to 15.82 mL and 8.16% to 3.17%, respectively (p < 0.001); however, these parameters for the left lung increased from 124.32 to 223.27 mL (p < 0.001) and 13.33% to 13.99% (p = 0.350). In addition, the average of heart and left lung displacement magnitudes were calculated at 7.32 and 20.91 mm, respectively. Conclusion The DIBH is an effective technique in the reduction of the heart dose for tangentially treated left sided-breast cancer patients, without a detrimental effect on the left lung.
Increase of wall shear stress caused by arteriovenous fistula reduces neointimal hyperplasia after stent implantation in healthy arteries

Background and objectives Wall shear stress plays a critical role in neointimal hyperplasia after stent implantation. It has been found that there is an inverse relation between wall shear stress and neointimal hyperplasia. This study hypothesized that the increase of arterial wall shear stress caused by arteriovenous fistula could reduce neointimal hyperplasia after stents implantation. Methods and results Thirty-six male rabbits were randomly divided into three groups: STENT, rabbits received stent implantation into right common carotid artery; STENT/arteriovenous fistula, rabbits received stent implantation into right common carotid artery and carotid-jugular arteriovenous fistula; Control, rabbits received no treatment. After 21 days, stented common carotid artery specimens were harvested for histological staining and protein expression analysis. In STENT group, wall shear stress maintained at a low level from 43.2 to 48.9% of baseline. In STENT/arteriovenous fistula group, wall shear stress gradually increased to 86% over baseline. There was a more significant neointimal hyperplasia in group STENT compared with the STENT/arteriovenous fistula group (neointima area: 0.87 mm2 versus 0.19 mm2; neointima-to-media area ratio: 1.13 versus 0.18). Western blot analysis demonstrated that the protein level of endothelial nitric oxide synthase in STENT group was significantly lower than that in STENT/arteriovenous fistula group, but the protein levels of proliferating cell nuclear antigen, vascular cell adhesion molecule 1, phospho-p38 mitogen-activated protein kinase (Pp38), and phospho-c-Jun N-terminal kinase in STENT group were significantly higher than that in the STENT group. Conclusion High wall shear stress caused by arteriovenous fistula as associated with the induction in neointimal hyperplasia after stent implantation. The underlying mechanisms may be related to modulating the expression and activation of endothelial nitric oxide synthase, vascular cell adhesion molecule 1, p38, and c-Jun N-terminal kinase.
Joint Optimization of Deep Neural Network-Based Dereverberation and Beamforming for Sound Event Detection in Multi-Channel Environments

In this paper, we propose joint optimization of deep neural network (DNN)-supported dereverberation and beamforming for the convolutional recurrent neural network (CRNN)-based sound event detection (SED) in multi-channel environments. First, the short-time Fourier transform (STFT) coefficients are calculated from multi-channel audio signals under the noisy and reverberant environments, which are then enhanced by the DNN-supported weighted prediction error (WPE) dereverberation with the estimated masks. Next, the STFT coefficients of the dereverberated multi-channel audio signals are conveyed to the DNN-supported minimum variance distortionless response (MVDR) beamformer in which DNN-supported MVDR beamforming is carried out with the source and noise masks estimated by the DNN. As a result, the single-channel enhanced STFT coefficients are shown at the output and tossed to the CRNN-based SED system, and then, the three modules are jointly trained by the single loss function designed for SED. Furthermore, to ease the difficulty of training a deep learning model for SED caused by the imbalance in the amount of data for each class, the focal loss is used as a loss function. Experimental results show that joint training of DNN-supported dereverberation and beamforming with the SED model under the supervision of focal loss significantly improves the performance under the noisy and reverberant environments.
Development of quantitative MRI as an outcome measure in Charcot-Marie-Tooth disease and inclusion body myositis

Lack of sensitive outcome measures is a major obstacle to clinical trials in many neuromuscular diseases (NMD). Lower limb muscle MRI allows non-invasive visualisation of acute and chronic pathology in NMD. This thesis aims to assess the reliability, validity and responsiveness of quantitative MRI in chronic neuromuscular diseases. A comprehensive quantitative MRI protocol of lower limb muscles was developed including T1, T2, fat fraction and magnetisation transfer ratio (MTR) measurements. The protocol was assessed for reliability and sensitivity to physiological variation in 47 healthy volunteers with 15 rescanned at a two week interval. This protocol was then performed together with detailed clinical assessments and isokinetic/isometric dynamometry in 20 patients with inclusion body myositis (IBM), 20 patients with Charcot-Marie-Tooth disease (CMT) and matched health volunteers twice at a 12 month interval. In the healthy volunteers, the inter-scan and inter-observer reliability was high (ICC 0.62-0.99) despite small observed physiological variation between subjects. Fat fraction, T2 and MTR showed significant correlations with subject age in thigh and calf muscles and with subject weight in thigh muscles whereas gender did not influence quantitative parameters. Cross-sectional analysis showed strong correlations with both muscle strength and clinical severity measures demonstrating validity of MRI measurements as outcome measures. Longitudinal assessment demonstrated excellent sensitivity to change of MRI measures; in particular muscle fat fraction quantification exceeded that of myometry and clinical measurements with standardised response mean (SRM) over 12 months of 1.1 in IBM and 0.8 in CMT indicating a high level of responsiveness. Annual change in fat fraction could be predicted based on baseline MRI measurements, providing the opportunity to improve SRM further. This thesis demonstrates the reliability, validity and responsiveness of quantitative MRI as an outcome measure providing a comprehensive practical protocol for clinical trials in NMD.