Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term Outcomes After Shunt Implantation in Patients With Posttraumatic Hydrocephalus and Severe Conscious Disturbance

Background Posttraumatic hydrocephalus (PTH) is a frequent complication secondary to traumatic brain injury, especially among patients keeping chronic unconscious. And effects of shunt implantation on improving outcomes among these patients are still controversial. This study was aimed to assess the long-term outcomes following shunt implantation among patients who had PTH and kept chronic unconscious. Methods A prospective study was performed to include patients who had PTH and remained in severe conscious disturbance from March 2010 to December 2010. All of included patients would have shunt implantation and be closely followed up at least for 2 years to assess final outcomes. Results Fifteen patients having PTH were identified. Before shunt implantation, 2 patients kept vegetative state (Glasgow Outcome Scale [GOS] score 2), and 13 patients kept minimally consciousness with severe disability (GOS score 3). After shunt implantation, the shunt device was removed because of intracranial infection in 1 patient, and the other patient died because of allergic shock. Among the remaining 13 patients, finally 7 patients had improvement on GOS or Modified Barthel Index (MBI) score during the 2-year follow-up, but only 1 patient achieved a good outcome (GOS score 4, independent life). Among them, 5 patients’ outcomes improved as assessed by GOS or MBI score during the first 3 months following shunt implantation. During the fourth to sixth month following shunt implantation, there were 2 patients who showed first rise on GOS or MBI score. Beyond 6 months, no patient showed initial improvement. And among patients who showed improvement, most of them kept improving during a certain time. Conclusions A proportion of patients who had PTH and remained in severe conscious disturbance would benefit from shunt implantation, and the improvement may turn up late after this procedure.
Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations

Myo18B is an unconventional myosin family protein expressed predominantly in muscle cells. Although conventional myosins are known to be localized on the A‐bands and function as a molecular motor for muscle contraction, Myo18B protein was localized on the Z‐lines of myofibrils in striated muscles. Like Myo18A, another 18th class of myosin, the N‐terminal unique domain of the protein and not the motor domain and the coiled‐coil tail is critical for its localization to F‐actin in myocytes. Myo18B expression was induced by myogenic differentiation through the binding of myocyte‐specific enhancer factor‐2 to its promoter. Deficiency of Myo18B caused an embryonic lethality in mice accompanied by disruption of myofibrillar structures in cardiac myocytes at embryonic day 10.5. Thus, Myo18B is a unique unconventional myosin that is predominantly expressed in myocytes and whose expression is essential for the development and/or maintenance of myofibrillar structure.
Antibacterial Diterpenic Acids from Brazilian Propolis

Abstract Four labdane-type diterpenic acids and syringaldehyde were isolated and identified from Brazilian propolis. A ll the compounds exhibit antibacterial activity. The diterpenes, found for the first time in propolis, are typical for some Araucaria species and thus indicate a possible plant source of Brazilian propolis.
Characterization and identification of gram-negative, nonfermentative bacteria

The morphological and physiological characteristics of 593 strains of nonfermentative, gram-negative bacteria are described. A battery of 46 tests was used to identify and differentiate strains representing 8 genera and 31 species of named and group-designated bacteria. Seven selected amides and organic salts were closely examined to determine their usefulness, individually or as a battery, in characterizing and identifying the organisms. Of these, allantoin and acetamide showed the most promise in differentiating the more commonly occurring organisms from biochemically similar species. Susceptiblilty patterns to 12 antimicrobics also proved useful in differentiation, especially among atypical strains.
Bacterial Association withParticles : Aggregation to Dissolution

Particles are all those biogeochemical entities encompassing the microscopic matter, both living and non-living. Smaller particles including microaggregates, phytoplankton, fecal pellets, organic debris and clay mineral particles (Alldredge, 1989) lead to the formation of aggregates in aquatic media due to their coagulative nature. They also include organisms, like bacteria, protozoans and metazoans, which are components of aggregates in aquatic environments (Grieser, 1988; Eisma, 1992; Laybourne-Parry et al., 1992; Rogerson and Laybourne-Parry, 1992a,b; Kies 1995; Zimmermann and Kausch, 1996), each with their own communities of attached microorganisms in various nutritional states. The “organic” particles include viruses (0.02 – 0.03 μm), bacteria (>0.22-1 μm), picoplankton (<5 μm), polysaccharide strings and sheets (3 to >100 μm) and detritus (0.5 – 2500 μm). “Inorganic” comprise of clay minerals (200-1000 μm) aluminosilicates (2001000 nm) and iron colloids (100 – 500 nm) or a combination of any of these. They are present as solitary particles or aggregates of different types of particles in the processes of the turnover, decomposition and sinking flux of both organic and inorganic matter in aquatic systems. Physical aggregation process of these particles may be enhanced by exudates, exopolymers and products of cell lysis generated by attached microorganisms which increase the stickiness of colliding particles and form a mucilaginous matrix in which many components become embedded (Alldredge, 1989). Aggregated materials are mostly in the turbid zone where the freshwater in the river mixes with seawater (Kies, 1995). In estuarine waters, phytoplankton, plankton detritus and heterotrophic consumers form an obvious source of suspended particles (Laane, 1982). Flocculation is an important process in controlling the settling velocities of particles and during the tidal cycles there may be changes in the particle size distribution in estuaries (Dyer, 1986). In addition, abundance and size of aggregates undergo considerable seasonal (Kies, 1995; Zimmermann and Kausch, 1996) and spatial variation (Kies, 1995). Colloids, which range in size of 0.001-1mm represent 10 to 50% of total ‘dissolved’ organic carbon (DOC) in seawater (Ogawa and Ogura, 1992; Benner et al., 1992; Guo et al., 1994) and may coagulate to form larger particles (Wells and Goldberg, 1993). Kepkays’ (1994) review on coagulation has brought out that bubbling may enhance coagulation of submicron particles, suggesting that coagulation rates may be high in surface waters. Alldredge et al. (1993) suggest that polysaccharide-rich, transparent exopolymer particles (TEP) are formed by coagulation of submicron particles.
The effect of different local anesthesia methods on pain relief in outpatient endometrial biopsy: randomized clinical trial.

INTRODUCTION Endometrial biopsy is necessary for diagnosing the reason of abnormal uterine bleeding in perimenopausal women. Currently outpatient endometrial biopsy is used for evaluation of abnormal uterine bleeding which is associated with moderate to severe pain. Using lidocaine is one of the procedures which is used for pain relief while biopsy. This study is aimed at comparing the effect of different local anesthesia procedures on pain relief during endometrial biopsy. METHODS In this randomized clinical trial, 160 multiparous 40-55 years old women with AUB, candidates for endometrial biopsy, were randomly assigned into four equal groups, to receive: 1-intrauterine lidocaine; 2-cervical spray lidocaine; 3- intrauterine lidocaine plus cervical spray lidocaine; or 4-intrauterine distilled water. Pain relief was measured at 3 different times: during endometrial biopsy, just after and 15 minutes after biopsy. RESULTS Pain intensity was reduced significantly at different times in intrauterine lidocaine and intrauterine lidocaine with cervical spray lidocaine receivers in compare with the groups which received cervical spray lidocaine and distilled water. The mean of difference pain relief during biopsy and 15 minutes after that was reduced significantly in the group which received intrauterine lidocaine and intrauterine lidocaine with cervical spray lidocaine in comparison with the other two groups. CONCLUSION Intrauterine lidocaine was effective during endometrial biopsy, and using it with cervical spray lidocaine had no more beneficial effect.
Adaptive sliding mode control design for quadrotor unmanned aerial vehicle

This paper addresses the stability and tracking control problem of quadrotor unmanned flying vehicle (UAV) in the presence of uncertainty. Adaptive autonomous sliding mode tracking system is designed by combining robust and adaptive control theory. Lyapunov analysis shows that the proposed algorithms can guarantee asymptotic convergence of the tracking error of the linear and angular motion dynamics of the vehicle. Compared with other existing adaptive backstepping design, the proposed method is very simple and easy to implement on an actual system as it does not require multiple design steps without augmented signals and a priori known bound of the uncertainty. To illustrate the theoretical argument, evaluation results on custom made quadrotor UAV system are presented for real-time applications.
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission

The amyloid precursor protein (APP), a key player in Alzheimer's disease, belongs to the family of synaptic adhesion molecules (SAMs) due to its impact on synapse formation and synaptic plasticity. These functions are mediated by both the secreted APP ectodomain that acts as a neurotrophic factor and full-length APP forming trans-cellular dimers. Two homologs of APP exist in mammals: the APP like proteins APLP1 and APLP2, exhibiting functions that partly overlap with those of APP. Here we tested whether APLP1 and APLP2 also show features of SAMs. We found that all three family members were upregulated during postnatal development coinciding with synaptogenesis. We observed presynaptic and postsynaptic localization of all APP family members and could show that heterologous expression of APLP1 or APLP2 in non-neuronal cells induces presynaptic differentiation in contacting axons of cocultured neurons, similar to APP and other SAMs. Moreover, APP/APLPs all bind to synaptic-signaling molecules, such as MINT/X11. Furthermore, we report that aged APLP1 knock-out mice show impaired basal transmission and a reduced mEPSC frequency, likely resulting from reduced spine density. This demonstrates an essential nonredundant function of APLP1 at the synapse. Compared to APP, APLP1 exhibits increased trans-cellular binding and elevated cell-surface levels due to reduced endocytosis. In conclusion, our results establish that APLPs show typical features of SAMs and indicate that increased surface expression, as observed for APLP1, is essential for proper synapse formation in vitro and synapse maintenance in vivo. SIGNIFICANCE STATEMENT According to the amyloid-cascade hypothesis, Alzheimer's disease is caused by the accumulation of Aβ peptides derived from sequential cleavage of the amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase. Here we show that all mammalian APP family members (APP, APLP1, and APLP2) exhibit synaptogenic activity, involving trans-synaptic dimerization, similar to other synaptic cell adhesion molecules, such as Neuroligin/Neurexin. Importantly, our study revealed that the loss of APLP1, which is one of the major substrates of BACE1, causes reduced spine density in aged mice. Because some therapeutic interventions target APP processing (e.g., BACE inhibitors), those strategies may alter APP/APLP physiological function. This should be taken into account for the development of pharmaceutical treatments of Alzheimer's disease.
Use of Coagulase Gene (coa) Repeat Region Nucleotide Sequences for Typing of Methicillin-Resistant Staphylococcus aureus Strains

ABSTRACT Coagulase gene (coa) short sequence repeat region sequencing was used to measure relatedness among a collection of temporally and geographically diverse methicillin-resistantStaphylococcus aureus isolates. The results show thatcoa polymorphism is free of strong selective pressure and has a low index of variation that may be useful for long-term epidemiological investigations. coa typing is a useful addition to spa typing for analysis of S. aureus, including methicillin-resistant strains.
Performance Assessment of Tuning Methods for PID Controller Parameter used for Position Control of DC Motor

In this paper, a comparison is made for tuning methods of PID controller to improve the performance of the position control system of DC motor. Firstly, the PID controller is tuned using conventional Ziegler –Nichols method and then by using Simulink Response Optimization tool box available in MATLAB software. Further, Fuzzy gain scheduling of PID controller is investigated in which fuzzy rules are utilized on-line to adapt the PID controller parameters based on the error and its first time derivative. The result shows that the gain scheduling scheme for DC motor position control system have presented superior performance compared to other methods.
Structure-function approach to vector-boson scattering in pp collisions.

We discuss weak-vector-boson scattering, at next-to-leading order in QCD within the framework of hadronic structure functions. We use this approach to calculate the Higgs-boson production cross section via vector-boson fusion at the CERN Large Hadron Collider and the Superconducting Super Collider; we find a modest increase over the leading-order prediction. We also give expressions for the distribution of vector bosons in a proton (effective-[ital W] approximation) including [ital O]([alpha][sub [ital s]]) corrections.
Modulation of peptide binding by HLA‐B27 polymorphism in pockets A and B, and peptide specificity of B*2703

The results in this study address three aspects of peptide binding to the disease‐associated antigen HLA‐B27 and its modulation by polymorphism: the contribution of major anchor residues 2 and 9, the role of pocket B polymorphism in modulating peptide specificity, and the binding properties of B*2703, a subtype not found to be associated with spondyloarthropathy. Synthetic analogs of peptides naturally presented by B*2705 were used to demonstrate that residue 2 is essential, since Ala2 analogs bound marginally to B*2705, but the specificity of B*2705 for Arg2 is not absolute, and show that the contribution of basic residue 9 to binding was significant, but less than Arg2. The effect of single mutations in the B pocket was to decrease or ‐ with the Glu > Met‐45 mutation ‐ totally shift pocket B specificity for Arg2 towards other residues at this position. This was shown by quantitating the relative binding of Gln2 and Ala2 analogs, and by pool‐sequencing of the peptides bound in vivo to these mutants. Peptides naturally presented by B*2705 apparently bound with a lower affinity to pocket A variants with altered hydrogen bonding to the peptide N terminus, including B*2703. Binding of peptide analogs with changes at positions 2 or 9 suggested that in B*2703 pocket A, interactions are weaker and pocket B interactions are stronger than in B*2705. This can be explained by the effect of the unique His59 change in B*2703 in both pockets. Thus, B*2703 is probably the HLA‐B27 subtype with the most stringent specificity for the Arg2 peptide motif.
AVALIAÇÃO FISIOTERAPÊUTICA EM NEONATOS QUE APRESENTARAM ASFIXIA PERINATAL E QUE FORAM SUBMETIDOS À HIPOTERMIA TERAPÊUTICA

Introducao: Aasfixia neonatal ainda e uma patologia que contribui grandemente para amortalidade perinatal e neonatal e e responsavel por graves sequelas querepresentam um onus significativo para a familia, a sociedade e o pais. Descricao do Relato de Caso: Seraoapresentados oito casos de neonatos que sofreram asfixia neonatal que foramsubmetidos ao protocolo de hipotermia terapeutica nas primeiras horas de vida.Foi realizado exame de Triagem Neuromotora Neonatal previamente a altahospitalar, e posteriormente, no ambulatorio de seguimento, com um ano de vida,sendo aplicado a Alberta Infant MotorScale. Resultados: Participaram8 bebes a termos, na avaliacao de Triagem Neuromotora Neonatal, 6 bebesapresentaram normotonia, um bebe hipertonia e um bebe hipotonia. Na avaliacaoambulatorial, realizada com os mesmos bebes apresentando um ano de vida.Daqueles 6 bebes que apresentaram normotonia, 4 bebes apresentaramdesenvolvimento motor normal para idade e 2 bebes apresentaram desenvolvimentomotor anormal. Um bebe que apresentou hipotonia na primeira avaliacao, tevedesenvolvimento anormal na avaliacao com um ano de vida. E um bebe apresentouhipertonia na avaliacao inicial, nao realizou seguimento no ambulatorio. Conclusao: Atraves destes resultadospode-se observar que, mesmo os bebes que inicialmente apresentaram escoresdentro da normalidade, podem apresentar atraso no seu desenvolvimento motor aolongo do primeiro ano de vida, bem como aquele que ja apresentava alteracao detonus na avaliacao pre alta, permaneceu com um desenvolvimento inadequado paraa idade. Sugerimos a realizacao de mais estudos com um numero maior departicipantes para obter resultados mais conclusivos.
Sugar uptake into brush border vesicles from normal human kidney.

Uptake studies of simple sugars were performed on a membrane fractions containing osmotically active vesicles prepared from normal human kidney cortex. The uptake of D-glucose was found to be sodium-dependent and phlorizin-sensitive. The specificity of the D-glucose transport mechanism is such that it is shared by alpha-methyl-D-glucoside, D-galactose, and 5-thio-D-glucose, while 2-deoxy-D-glucose, 3-O-methyl-D-glucose, D-mannose, and D-fructose show little, if any, affinity. Measurement of the sodium-dependent component of the initial D-glucose uptake as a function of glucose concentration resulted in a curvilinear Scatchard plot, indicating the possibility of cooperative effects, or alternatively, the existence of two (or more) sodium-dependent D-glucose transporters. In the case of two transporters, we estimate that Km congruent to 0.3 mM and Vmax congruent to 2.5 nmol/min per mg of protein for the "high-affinity transporter," and Km approximately 6 mM and Vmax approximately 8 nmol/min per mg of protein for the "low-affinity transporter. " These specificity and kinetic properties strongly suggest that the sodium-dependent D-glucose transport mechanism characterized in our studies is localized to the brush border of the proximal tubule.
Subdivision Beyond Smoothness

This paper examines the role that subdivision processes can have in the production of form. It explores how subdivision processes can generate complex geometries from very simple input meshes. In a first step, this paper presents modifications to the established subdivision processes' weighting schemes. In a second step, this paper considers formalized and extended methods for applying these schemes. Finally the paper presents forms generated with these modified processes.
An analysis of privacy preservation schemes in cloud computing

The amount of data usage is high appreciated day by day with the next generation technologies. Technologies encourage the users to perform day to day and research activities in the field of data management, which also improves the automation of such human, machine interaction across the world. To handle the increased data population, in today's scenario the only technology house suggested is cloud data storage. The cloud computing model helps to manage and maintain the data with various services and deployment models. Outsourcing the data in the cloud gives a big relief for data storage in local machines. But, the security of the outsourced data is still an challenging issue. Privacy loss of the user's data affects the reliable service delivery in cloud. Most researchers have proposed some encryption techniques which helps to ensure privacy for a particular level in cloud. Based on the survey done by various researchers, No complete privacy preservation system is available in today's world. In this paper, comparative study on privacy preservation schemes in cloud provides a clear view on the privacy issues and methods to preserve in the cloud data storage.
Augmentation of Cellular Immunity and Reduction of Influenza Virus Titer in Aged Mice Fed Lactobacillus casei Strain Shirota

ABSTRACT We investigated whether oral administration of Lactobacillus casei strain Shirota activates the cellular immune system and ameliorates influenza virus (IFV) titer in the nasal site in upper respiratory IFV infection by using aged mice. Natural killer activity of splenocytes and lung cells of aged mice fed an L. casei strain Shirota diet (L.casei strain Shirota group) was significantly (P < 0.01 and P < 0.05) increased compared to those fed a control diet (control group). The increases were 1.5- and 2.5-fold, respectively. In aged mice fed an XL.casei strain Shirota diet, potent induction of gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α), which play a very important role in excluding IFV, was evident in nasal lymphocytes. IFN-γ and TNF-α production increased 12- and 3.5-fold, respectively. In this model of upper respiratory IFV infection, the titer of IFV in the nasal washings of aged mice fed an L.casei strain Shirota diet was significantly (P < 0.05) lower than that in aged mice fed a control diet (101.6 ± 0.6 and 102.2 ± 0.5, respectively). These findings suggest that oral administration of L.casei strain Shirota activates not only systemic cellular immunity but also local cellular immunity and that it ameliorates IFV infection.
Flocculated amorphous itraconazole nanoparticles for enhanced in vitro supersaturation and in vivo bioavailability

Rapid flocculation of nanoparticle dispersions of a poorly water soluble drug, itraconazole (Itz), was utilized to produce amorphous powders with desirable dissolution properties for high bioavailability in rats. Antisolvent precipitation (AP) was utilized to form Itz nanodispersions with high drug loadings stabilized with hydroxypropylmethylcellulose (HPMC) or the pH-sensitive Eudragit® L100-55 (EL10055). The HPMC dispersions were flocculated by desolvating the polymer through the addition of a divalent salt, and the enteric EL10055 by reducing the pH. The formation of open flocs by diffusion limited aggregation facilitated redispersion of the flocs at pH 6.8. Upon redispersion of the flocculated nanoparticles at pH 6.8, the particle size was modestly larger than the original size, on the order of 1 μm. High in vitro supersaturation (AUC) of the flocculated nanoparticle dispersions was observed in micellar media at pH 6.8, after 2 hours initial exposure at pH 1.2 to simulate the stomach, relative to the AUC for a commercially available Itz formulation, Sporanox. Greater in vivo bioavailability in rats was correlated directly to the higher in vitro AUC at pH 6.8 with micelles during the pH shift experiment for the flocculated nanoparticle dispersions relative to Sporanox. The ability to generate and sustain high supersaturation in micellar media at pH 6.8, as shown with the in vitro pH shift dissolution test, is beneficial for increasing bioavailability of Itz by oral delivery.