Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimal feature selection for partial discharge recognition of cable systems based on the random forest method

Optimal feature selection is one of the most significant challenges of Partial Discharge (PD) pattern recognition of cable system as the number of PD features is with large quantity, which reduces the efficiency of PD pattern recognition methods and restricts the effectiveness of PD based condition monitoring and diagnostics. To overcome the challenge a random forest method is presented in the paper to select the most effective PD features from 18 different kinds of features. Firstly, PD data from five types of artificial defects based on IEC 60270 system in High Voltage (HV) lab is introduced. Secondly, PD data pre-processing and feature extraction are carried out and 18 kinds of PD features are extracted from the raw data. Thirdly, the random forest method based optimal feature selection is presented in details and compared with Lasso method. Finally, the feature selection methods are evaluated with Random Forest and Logistic Regression based PD pattern recognition method. The top 6 features are recommended for PD pattern recognition based on the experimental data and the random forest method.
BEEF SAFETY BEEF DECONTAMINATION TECHNOLOGIES

Introduction Beef carcasses, which are initially sterile, become contaminated with bacterial pathogens via transmission of organisms from the exterior of the live animal, and/or from the environment, to the product surface. Extensive contamination, or abusive conditions that allow bacteria to reproduce, increase risk for presence of pathogenic bacteria and formation of toxins in food (Sofos et al., 1999). Highly publicized outbreaks of foodborne disease since 1993, primarily caused by bacteria such as Escherichia coli O157:H7 and Listeria monocytogenes, elicited intense consumer concern about meat safety. In response, regulatory authorities, researchers, and the beef industry initiated efforts to implement food safety management systems to improve microbiological quality. To improve beef safety, the USDA Food Safety and Inspection Service (FSIS) began initiating new regulatory requirements during the mid-1990s. Packers now must knife-trim carcasses to remove all visible contaminants, must comply with written sanitation standard operating procedures (SSOP), must have implemented hazard analysis critical control point (HACCP) systems, and must meet microbiological performance criteria and standards for Escherichia coli and Salmonella as a means to verify HACCP effectiveness and pathogen reduction. Researchers and beef packers/processors addressed consumer food safety concerns by developing a variety of methods that are now implemented, or are being further developed, to reduce numbers of bacteria on beef and improve microbiological safety (Sofos et al., 1999). These microbiological decontamination technologies include animal cleaning, chemical dehairing at slaughter, spot-cleaning of carcasses by knife-trimming or steam/hotwater vacuuming, and spraying/washing/rinsing of carcasses before evisceration and/or before chilling, with water, chemical solutions and/or steam or hot water. Research has demonstrated that such decontamination technologies are most effective when used in combination, sequentially, as multiple hurdles systems. Such systems improve regulatory compliance and enhance product safety (provided that processing and preparation for consumption also are performed using good hygiene practices) and are the topic here.
Digital Laser Frequency Control and Phase-Stabilization Loops in a High Precision Space-Borne Metrology System

We report on the design, implementation, and characterization of fully digital control loops for laser frequency stabilization, differential phase-locking, and performance optimization of the optical metrology system on-board the LISA Pathfinder space mission. The optical metrology system consists of a laser with modulator, four Mach-Zehnder interferometers, a phase-meter and a digital processing unit for data analysis. The digital loop design has the advantage of easy and flexible controller implementation and loop calibration, automated and flexible locking and resetting, and improved performance over analog circuitry. Using the practical ability of our system to modulate the laser frequency allows us to accurately determine the open-loop transfer function and other system properties. Various noise sources and their impact on system performance are investigated in detail.
Modeling Financial Sector Joint Tail Risk in the Euro Area

We develop a novel high-dimensional non-Gaussian modeling framework to infer measures of conditional and joint default risk for numerous financial sector firms. The model is based on a dynamic Generalized Hyperbolic Skewed-t block-equicorrelation copula with time-varying volatility and dependence parameters that naturally accommodates asymmetries, heavy tails, as well as non-linear and time-varying default dependence. We apply a conditional law of large numbers in this setting to define joint and conditional risk measures that can be evaluated quickly and reliably. We apply the modeling framework to assess the joint risk from multiple defaults in the euro area during the 2008-2012 financial and sovereign debt crisis. We document unprecedented tail risks between 2011-2012, as well as their steep decline following subsequent policy actions. JEL Classification: G21, C32
Unregulated brain iron deposition in transgenic mice over‐expressing HMOX1 in the astrocytic compartment

The mechanisms responsible for pathological iron deposition in the aging and degenerating mammalian CNS remain poorly understood. The stress protein, HO‐1 mediates the degradation of cellular heme to biliverdin/bilirubin, free iron, and CO and is up‐regulated in the brains of persons with Alzheimer's disease and Parkinson's disease. HO‐1 induction in primary astroglial cultures promotes deposition of non‐transferrin iron, mitochondrial damage and macroautophagy, and predisposes cocultured neuronal elements to oxidative injury. To gain a better appreciation of the role of glial HO‐1 in vivo, we probed for aberrant brain iron deposition using Perls' method and dynamic secondary ion mass spectrometry in novel, conditional GFAP.HMOX1 transgenic mice that selectively over‐express human HO‐1 in the astrocytic compartment. At 48 weeks, the GFAP.HMOX1 mice exhibited increased deposits of glial iron in hippocampus and other subcortical regions without overt changes in iron‐regulatory and iron‐binding proteins relative to age‐matched wild‐type animals. Dynamic secondary ion mass spectrometry revealed abundant FeO− signals in the transgenic, but not wild‐type, mouse brain that colocalized to degenerate mitochondria and osmiophilic cytoplasmic inclusions (macroautophagy) documented by TEM. Sustained up‐regulation of HO‐1 in astrocytes promotes pathological brain iron deposition and oxidative mitochondrial damage characteristic of Alzheimer's disease‐affected neural tissues. Curtailment of glial HO‐1 hyperactivity may limit iron‐mediated cytotoxicity in aging and degenerating neural tissues.
Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

Recent evidence indicates that reactive oxygen species (ROS) may function as intracellular messengers in receptor signaling pathways. The possible role of ROS in epidermal growth factor (EGF) signaling was therefore investigated. Stimulation of A431 human epidermoid carcinoma cells with EGF resulted in a transient increase in the intracellular concentration of ROS, measured with the oxidation-sensitive fluorescent probe 2′,7′-dichlorofluorescin diacetate and laser-scanning confocal microscopy. The predominant ROS produced appeared to be H2O2, because the EGF-induced increase in fluorescence was completely abolished by incorporation of catalase into the cells by electroporation. The elimination of H2O2 by catalase also inhibited the EGF-induced tyrosine phosphorylation of various cellular proteins including the EGF receptor and phospholipase C-γ1. The dependence of H2O2 production on the intrinsic tyrosine kinase activity of the EGF receptor and the autophosphorylation sites located in its COOH-terminal tail was investigated. EGF failed to induce H2O2 generation in cells expressing a kinase-inactive EGF receptor. However, normal H2O2 generation was observed in cells expressing a mutant receptor from which the 126 COOH-terminal amino acids had been deleted to remove four (out of the total of five) autophosphorylation sites. These results suggest that EGF-induced H2O2 formation requires the kinase activity but probably not the autophosphorylation sites of the EGF receptor and that inhibition of protein tyrosine phosphatase activity by H2O2 may be required for EGF-induced protein tyrosine phosphorylation to be manifested.
Metamaterial-corrugated fermi tapered slot antenna for MMW applications

A novel approach is presented to increase the realized gain for millimeter wave applications at 28 GHz using metamaterial (MTM) profile based antennas. The concept of epsilon-negative medium (ENG) and double negative medium (DNG) is analyzed to have metamaterial corrugations instead of sine corrugations. In this paper, the antipodal Fermi based tapered slot antenna (AFTSA) is analyzed using metamaterial corrugations which allow a total gain greater than 14 dB in the H-plane for a frequency range of 24–30 GHz. The extraction of effective parameters of a metamaterial unit cell is also presented depicting its ENG and DNG behavior. The antenna is also analyzed using the practical model of a 2.92 mm connector, thereby showing the effect of end launch connectors on the millimeter wave frequency range.
Phase‐contrast hard X‐ray microscopy using synchrotron radiation for the properties of skeletal muscle in mouse hind limbs

Radiation beam interface contrast X‐ray microscopy provides resolution of a few dozen nanometers from fixed whole muscle biopsies, allowing better reconstruction of the microstructure of the muscle than is currently possible with classic histological techniques. Fixed soleus muscle biopsies have been evaluated from the walk‐in mouse model using phase‐contrast X‐ray microscopy, and results presented that corroborate the accuracy of the method used, and its potential for application in physiotherapy and occupational therapy studies. We believe that this method will enhance existing morphometric methods of analysis, leading to accurate reconstruction of other thick specimens that would otherwise require thin sectioning and reconstruction through deconvolution algorithms.
Hysterectomy and ovarian removal--a major health issue in the perimenopausal years.

or implantation events. The current political power of this minority has stalemated federal policy and even medical research in this area for most ofthe past decade. When it comes to the future of contraception, the crystal ball is murky. Science is still a steadfast hero, with monumental accomplishments and promising possibilities: spermicides and barriers that provide improved protection against both pregnancy and sexually transmitted infection; refined systemic steroid methods, possibly even for men; vaccines; and, in the more-distant future, a new generation of systemic methods that act on pregnancy-specific targets to block fertility without disrupting normal hormonal events. Bringing possibilities to actuality and making them available
Incidence of Virulence Factors and Antibiotic Resistance among Enterococci Isolated from Food

ABSTRACT The incidence of virulence factors among 48 Enterococcus faecium and 47 Enterococcus faecalis strains from foods and their antibiotic susceptibility were investigated. No strain was resistant to all antibiotics, and for some strains, multiple resistances were observed. Of E. faecium strains, 10.4% were positive for one or more virulence determinants, compared to 78.7% of E. faecalis strains. Strains exhibiting virulence traits were not necessarily positive for all traits; thus, the incidence of virulence factors may be considered to be strain specific.
A cis-acting sequence promotes removal of simian virus 40 DNA from the replication pool

Pulse-labeled simian virus 40 (SV40) DNA is removed from the pool of molecules available for replication (i.e., it ceases to reenter replication) a few hours after synthesis. We studied this cessation of reentry with mutants containing different deletions in the structural genes of SV40. The DNAs of two independent deletion mutants, dl-1007 (24% deletion) and dl-1003 (8% deletion), were used as templates for further DNA synthesis (i.e., they reentered replication) to a greater extent than was wild-type DNA. The alteration in reentry kinetics was not because the DNAs were smaller; other deletion mutations that were from 76 to 85% of the length of wild-type DNA (dl-BE and dl-1133 with a deletion in the late region and F8dl with a deletion in the early region) did not reenter replication to a greater extent than the wild type did. Cotransfection experiments showed that the mutant phenotypes of dl-1007 and dl-1003 were poorly complemented, if at all, by the wild type. Thus, we propose that there is a cis-acting sequence located in the HindIII E fragment of SV40, not present in either of these mutants, that promotes the efficient removal of DNA from the replication pathway.
Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein*

CLASP2 is a microtubule-associated protein that undergoes insulin-stimulated phosphorylation and co-localization with reorganized actin and GLUT4 at the plasma membrane. To gain insight to the role of CLASP2 in this system, we developed and successfully executed a streamlined interactome approach and built a CLASP2 protein network in 3T3-L1 adipocytes. Using two different commercially available antibodies for CLASP2 and an antibody for epitope-tagged, overexpressed CLASP2, we performed multiple affinity purification coupled with mass spectrometry (AP-MS) experiments in combination with label-free quantitative proteomics and analyzed the data with the bioinformatics tool Significance Analysis of Interactome (SAINT). We discovered that CLASP2 coimmunoprecipitates (co-IPs) the novel protein SOGA1, the microtubule-associated protein kinase MARK2, and the microtubule/actin-regulating protein G2L1. The GTPase-activating proteins AGAP1 and AGAP3 were also enriched in the CLASP2 interactome, although subsequent AGAP3 and CLIP2 interactome analysis suggests a preference of AGAP3 for CLIP2. Follow-up MARK2 interactome analysis confirmed reciprocal co-IP of CLASP2 and revealed MARK2 can co-IP SOGA1, glycogen synthase, and glycogenin. Investigating the SOGA1 interactome confirmed SOGA1 can reciprocal co-IP both CLASP2 and MARK2 as well as glycogen synthase and glycogenin. SOGA1 was confirmed to colocalize with CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein. These results introduce the metabolic function of these proposed novel protein networks and their relationship with microtubules as new fields of cytoskeleton-associated protein biology.
Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway

251 February 2013 P RACTICE Guidelines are systematically developed recommendations that assist the practitioner and patient in making decisions about health care. These recommendations may be adopted, modified, or rejected according to clinical needs and constraints and are not intended to replace local institutional policies. In addition, Practice Guidelines developed by the American Society of Anesthesiologists (ASA) are not intended as standards or absolute requirements, and their use cannot guarantee any specific outcome. Practice Guidelines are subject to revision as warranted by the evolution of medical knowledge, technology, and practice. They provide basic recommendations that are supported by a synthesis and analysis of the current literature, expert and practitioner opinion, open-forum commentary, and clinical feasibility data. This document updates the “Practice Guidelines for Management of the Difficult Airway: An Updated Report by
Estrategias de desarrollo bajo en carbono en megaciudades de América Latina

Contiene: Ciudades y desarrollo sostenible bajo en carbono. Marco conceptual. Analisis de instrumentos y politicas de sustentabilidad urbana en America Latina a nivel sectorial. Estrategias y medidas de politica fiscal e instrumentos economicos para apoyar procesos de mitigacion y adaptacion al cambio climatico. Transporte urbano bajo en emisiones de GEI: un juego de planificacion basado en un modelo de simulacion.
Effect of testosterone and estradiol in a man with aromatase deficiency.

Recent reports of disruptive mutations of the genes for the estrogen receptor or for cytochrome P-450 aromatase1–6 have shed new light on the role of estrogen. In females the lack of estrogen due to aromatase deficiency leads to pseudohermaphroditism and progressive virilization at puberty, whereas in males pubertal development is normal. In members of both sexes epiphyseal closure is delayed, resulting in a eunuchoid habitus, and osteopenia is present.6 These findings suggest a crucial role of estrogen in skeletal maturation.1–6 We describe the responses to androgen and estrogen in a man with a novel, homozygous inactivating mutation of .
Impact of strategic planning on profit performance Study of 57 corporations , with 620 diverse businesses , establishes relationship between strategic planning and profit performance

One of the most significant research projects undertaken by the Marketing Science Institute is the (ingoing profit impact of niiirket strategies (PIMS) studyThe basic idea bebehind PIMS is to provide corporate top management, divisional management, marketing executives, and corporate planners witb insigbts and information on expected profit performance of different kinds of husinesses under different competitive eonditions. Among the 37 factors investigated and analyzed are market share, total marketing expenditures, product quality, R&D expenditures, investment intensity, and so on. Tbese factors account for more than 80% of the variation in profit in the more tban fioo business units analyzed. In tbis article, the authors describe tbe highlights of tbeir research lindings. Mr. Schoeffler, director of applications for tbe PIMS project, is a senior visiting researcb fellow at Harvard Business Sebool; Mr. Buzzell, PIMS research director, is professor of business administration and cbairman of marketing at HBS; Mr. Heany, manager-reports and liaison for the PIMS program, is a visiting research fellow at HBS. What rate of return on investment (ROI) is "normal" in a given type of business, under given market and industry conditions? What factors explain differences in typical levels of ROI among various kinds of businesses?
Embryo transfer in pigs : current status and prospects for commercial applications

During the last decades of the twentieth century rapid scientific advances in embryo and reproductive technologies have been made, both in medical science and in animal sciences. Except for artificial insemination (AI), which is used on a large scale, no other embryo or reproductive technologies are currently routinely applied in commercial pig breeding or in the dissemination of superior genetics from pig breeding units to commercial herds. Surgical embryo collection and surgical embryo transfer have been used commercially for some time now (Brussow and Konig, 1988; Cameron et al., 1989), but only occasionally and to a very limited extend. Because of the high fecundity of pigs, the need for extra offspring per breeding female is less than in cattle breeding. However, the current use of new reproduction techniques in cattle breeding and the increased need for transfer of pig genetic material around the world with minimal health risks and low costs, lead to a stronger motivation to use new reproduction technologies in pig breeding and pig production. Important for the successful application of new reproduction techniques in cattle breeding programs, e.g. superovulation, nonsurgical embryo collection and transfer, ultrasound-guided transvaginal ovum pick-up, in vitro maturation and fertilization (IVM-IVF) of oocytes and embryo freezing, was the early development of a reliable, efficient technique for nonsurgical embryo transfer. Likewise it is to be expected that the availability of such a technique in pigs will contribute much to the development and commercial use of other reproduction technologies too. In this paper we will first review the state of the art as far as embryo transfer in pigs is concerned, with emphasis on the development of nonsurgical embryo transfer. Subsequently we will review the prospects for commercial applications of nonsurgical embryo transfer in combination with other reproduction techniques, including small scale-high value applications and potentially large scale applications which may have far-reaching consequences for the structure of the pig industry.
Nerve growth factor induced after temporomandibular joint inflammation decelerates chondrocyte differentiation.

OBJECTIVE The goal of this study was to investigate changes in nerve growth factor (NGF) and its high-affinity receptor-tropomyosin receptor kinase A (TrkA) expression in the TMJ after intra-articular inflammation. MATERIALS AND METHODS We employed the Col1-IL1β(XAT) inducible model of joint inflammation. Changes in NGF and TrkA expression were evaluated by immunohistochemistry. The function of NGF on cell differentiation was assessed in vitro employing the ATDC5 chondrocyte cell line. RESULTS NGF expression was observed in articular chondrocytes only after TMJ inflammation, whereas TrkA expression was detected in articular chondrocytes under both naïve as well as inflamed conditions. The potential effect of NGF on articular chondrocytes was studied on the ATDC5 cell line, whereby NGF decelerated the maturation rate of this chondrogenic cell line, presumably by arresting cell differentiation at the prehypertrophic stage of chondrocyte maturation. CONCLUSIONS NGF-TrkA signaling in the TMJ provides potentially a means of protection against the development of osteoarthritis by decelerating chondrocyte differentiation. This discovery may lead to the development of novel therapies for osteoarthritis of the TMJ and other joints.
IPMSM control regime for a hybrid-electric vehicle application

Due to its high torque density, the interior permanent magnet synchronous machine (IPMSM) is nowadays often used in electric vehicle applications. For an efficient machine operation, a proper control strategy has to be implemented. Because of the inherent non-linearities, the control is often based on lookup tables covering the entire operating area. The proposed control strategy relies on lookup tables only containing points on the edges of the operating area. This minimizes storage requirements and determination effort, while maintaining a sufficient level of accuracy.
Nonlinear PCA With the Local Approach for Diesel Engine Fault Detection and Diagnosis

This brief examines the application of nonlinear statistical process control to the detection and diagnosis of faults in automotive engines. In this statistical framework, the computed score variables may have a complicated nonparametric distribution function, which hampers statistical inference, notably for fault detection and diagnosis. This brief shows that introducing the statistical local approach into nonlinear statistical process control produces statistics that follow a normal distribution, thereby enabling a simple statistical inference for fault detection. Further, for fault diagnosis, this brief introduces a compensation scheme that approximates the fault condition signature. Experimental results from a Volkswagen 1.9-L turbo-charged diesel engine are included.