Miracle-dz/UniFAR-FTUs huggingface dataset:
The Ser/Thr Kinase MAP4K4 Controls Pro-Metastatic Cell Functions

The search for novel targeted therapies for major human conditions such as diabetes, cardiovascular diseases and cancer is a slow and costly process. Progress is often hampered by poor drug efficaciousness in the patients, low selectivity/specificity of the compounds and cellular evasion mechanism that are rather common in anti-cancer therapies. This is particularly true also for compounds inhibiting kinases, which in theory are optimal targets thanks to their druggable enzymatic activity. Novel targeting strategies are needed to reduce side effects and treatment failure caused by non-specific drug function and target resistance, respectively. An ideal compound will repress the relevant kinase effector function, while leaving kinase functions that are not disease-relevant unaltered. To achieve function-specific inhibition, the molecular mechanism of the drug target that governs the pathological process, must be identified. The Ser/Thr kinase MAP4K4 is implicated in inflammatory and metabolic disorders and cancer progression. In this review, we describe the molecular effector functions of MAP4K4 that exert those activities and how they have been identified and characterized both in invertebrate organisms and mammals. We discuss how the modulation of the cellular cytoskeleton by MAP4K4 may be connected to pathological conditions such as aberrant angiogenesis and cancer metastasis, and we describe the molecular mechanisms that are so far known to be mechanistically involved in these processes.
Gabor Filter based Thresholding Level Method for Medical Image Enhancement

--Digital image enhancement techniques provide a multitude of choices for improving the visual quality of images. A frequency domain smoothing-sharpening technique is proposed and its impact is assessed to beneficially enhance the lung cancer images. This technique aims to gain the advantages of enhance and sharpening process that aims to highlight sudden changes in the image intensity and identifying the level of image for diagnosis purpose. The already developed technique also eliminates the drawbacks of each of the two sharpening and smoothing techniques resulting from their individual application in image processing field. Significant improvement in contrast of masses along with the suppression of background information.The proposed technique is tested lung cancer images of average filter and thresholding of level. The simulated results show that the high potential to advantageously enhance the image contrast hence giving extra aid to radiologists to detect it damage portion in lung.
Evaluation of vegetal cover loss and its impact on surface temperature in Manipur valley using remote sensing and GIS technology, India

This study assesses forest cover change (1989â€“2016) in the Manipur valley using Landsat imageries and examines the quantum change in land surface temperature within the study area. Vegetation abundance is one of the most influential factors in controlling Land surface temperature. Vegetation change, NDVI and LST maps of four different dates are generated using Landsat TM images for 1989, 2002, 2009 and Landsat 8 OLI for 2016. Limited ground truth verification and field visits were conducted. The study reveals that the forests area decreased at an average annual rate of 330 ha year-1, amounting to a rate of loss of 8.6 % year-1 whereas the built-up area increases by 4 fold and the surface temperature simultaneously increases spatially over the study periods. The initial findings have shown that there is significant increase in the built-up areas, the conversion of forest cover into residential and commercial areas resulted in higher LST in impervious areas. Dense forest and water bodies comparatively observe low temperature than the built-up land. The study evaluates the relationship between the land surface temperature and vegetation cover loss, using Normalized vegetation index (NDVI) to indicate vegetation abundance. A strong negative correlation results between LST and NDVI, where the cooling effect of green areas can be observe. The results indicate a greater loss of the natural ecosystem to infrastructural development at the expense of forest class.
Simulation of Fluid Flow and Heat Transfer in the Inclined Enclosure

Mixed convection in two-dimensional shallow rectangular enclosure is considered. The top hot wa ll moves with constant velocity while the cold bottom wall has no motion. Simulations are performed for Richardson number ranging from Ri = 0.001 to 100 and for Reynolds number keeping fixed at Re = 408.21. Under these conditions cavity encompasses three regimes: dominating forced, mixed and free convection flow. The Prandtl number is set to 6 and the effects of cavity inclin ation on the flow and heat transfer are studied for different Richardson number. With increasing the inclination angle, interesting behav ior of the flow and thermal fields are observed. The streamlines and is otherm plots and the variation of the Nusselt numbers on the hot wal l are presented. The average Nusselt number is found to increase wit h cavity inclination for R i 1 ≥ . Also it is shown that the average Nusselt number changes mildly with the cavity inclination i n the dominant forced convection regime but it increases considera bly in the regime with dominant natural convection.
Synthesis, characterization and Insilico molecular docking studies of novel chromene derivatives as Rab23 inhibitors

The Rab23 protein overexpression has a well-validated role in variety of human cancers. Therefore, the present research aimed to identify new Rab23 protein inhibitor candidates using computational based drug design methodology. A novel series of chromeno[2,3-b] pyridine derivatives has been synthesized by the cyclocondensation of 2-amino-3-cyano-4H-chromenes with cyclohexanone and cyclopentanone in ethanolicpiperidine solution. The 2-amino-4H-chromenes were obtained using one pot multicomponent condensation of resorcinol, malononitrile and aromatic aldehydes in the presence in ethanolicpiperidine solution. All newly synthetic compounds were characterized by spectral analysis IR, NMR and MS and elemental analysis techniques. The best binding modes of chromene derivatives were evaluated via molecular docking studies and binding energy calculations, using PyRx tool. The study has shown that the pyran and pyridine moieties interact favorably with the binding site of target protein, providing the mechanism of action against human sapiens Rab23 protein.
GC-MS Analysis of insecticidal essential oil of aerial parts of Artemisia anomala S. Moore against Liposcelis bostrychophila Badonnel (Psocoptera: Liposcelididae)

Water-distilled essential oil from the aerial parts at flowering stage of Artemisia anomala (Compositae) was analyzed by gas chromatography-mass spectrometry (GC-MS). Thirty-three compounds, accounting for 97.46% of the total oil, were identified and the main components of the essential oil of A. anomala aerial parts were camphor (15.47%), 1,8-cineole (15.41%), caryophyllene oxide (9.27%), borneol (7.78%), and caryophyllene (6.55%) followed by spathulenol (4.57%) and carvone (4.32%). The essential oil has higher content of (55.27%) of sesquiterpenoids than monoterpenoids (40.29%). The essential oil of A. anomala aerial parts possessed strong fumigant toxicity against the booklice (Liposcelis bostrychophila) with an LC50 value of 4.05 mg/l. The essential oil also exhibited contact toxicity against L. bostrychophila with an LC50 value of 131.59 g/cm 2 . The results indicate that the essential oil of A. anomala aerial parts has potential for development into natural insecticides or fumigants for control of insects in stored grains.
Determinants of Sectoral Import in Manufacturing Industry: A Panel Data Analysis

This paper investigates determinants of sectoral import in Turkey’s manufacturing industry over a sample from 1998Q1 to 2012Q2 by using Augmented Mean Group analysis which is introduced by Eberhardt and Teal (2008) and developed by Eberhardt and Bond (2009). The model takes into account parameter heterogeneity and cross-sectional dependence. Cross-sectional dependence is tested by CD-Bias test of Pesaran (2008), while Cross-Sectionally Augmented Dickey-Fuller (CADF) test proposed by Pesaran (2007) is employed for testing for the presence of a unit root and cointegration among the variables is tested by using the methodology of Westerlund (2008). The regression results indicate that elasticities of import demand with respect to industrial production are different at sectoral level and coefficients of real exchange rate are significant and positive for almost all of the sectors. It is seen that the sectors with highest elasticities of import demand with respect to industrial production are basic metals, motor vehicles, eletrical machinery and textiles. Also, working day variable and crisis dummy are used to explore the impact of calendar day effect and global crisis.
Factorial Analyses, Equilibrium Studies, Kinetics and Thermodynamics of the Removal of Suspended Particles From an Industrial Effluent on Coal Based Activated Carbon

Batch adsorption has been used to study the adsorption performance of coal based activated carbon (COBAC) in a fibre-cement effluent (FCE) at room temperature and pH of 12. This paper demonstrates the use of analysis of variance (ANOVA) and Fisher’s least significant difference statistics in the determination of the adsorption performance of COBAC at varying time and various dosages. Increasing COBAC dosage and adsorption time respectively, had high significant differences on the adsorption performance of COBAC. In addition, time/dosage interactions had significant difference on COBAC adsorption performance. Adsorption dynamics studies show that ‘animekus’ expression for pseudo second order kinetic model gave the best predicted adsorption capacity values and as such, favours chemisorption mechanism. Thermodynamic studies reveal effective adsorption of suspended solids onto COBAC. Equilibrium studies revealed that adsorption data of suspended particles onto COBAC followed Langmuir pattern reaffirming chemisorption adsorption mechanism.
The effect of aerobic training on healthy elderly women's walking speed, step length and habitual physical activity

This study’s main aim was to investigate whether training could increase walking speed, step length and habitual physical activity (HPA) in elderly women. This randomized controlled trial was carried out with 22 elderly women, who were first monitored for a week (heart rate and movement), had their chosen and faster walking speed determined, as well as their step rate and length, and underwent sub maximal treadmill tests. Data from monitoring were organized into 7 HPA indices. The women were randomly allocated to a control (73.6±1.7 years) or exercise group (75.5±2.9). For 12 weeks the exercisers walked 3 times a week on a treadmill at 60-65% of their predicted HRR. Controls continued with their normal routine. Post-training, all measurements were repeated. Training was associated with significant increases in step length and walking speeds. However, no significant changes in the HPA indices were found. It is concluded that the three-month aerobic training program by treadmill walking resulted in significant increases in step length and self-selected walking speeds in these healthy, independent, elderly women, however, it did not lead to increased habitual physical activity.
Dental microwear study of pigs from the classical site of Sagalassos (SW Turkey) as an aid for the reconstruction of husbandry practices in ancient times

Abstract Microwear analysis of pig teeth from the classical site of Sagalassos (SW Turkey) is undertaken to obtain insight into pig management strategies in this region from the 1st to 7th centuries AD. Earlier research on modern pigs revealed significant differences in microwear patterns between stall-fed and free-ranging, rooting individuals. A comparison of the microwear data of the Sagalassos pig with those from archaeological and modern pigs with a known or presumed type of management shows that the microwear of the Sagalassos pigs is very different. It is suggested that the Sagalassos pigs had a very soft, non-abrasive diet, that in the first instance cannot be attributed to either management type. Therefore, the nature of the substrate on which the animals were foraging and its impact on microwear are considered and the microwear data are compared with the results of previous archaeozoological research carried out at the site. Further, diachronic changes in microwear patterns are investigated.
Impact of T 1 r 3 and Trpm 5 on Carbohydrate Preference and Acceptance in C 57 BL / 6 Mice

Knockout (KO) mice missing the sweet taste receptor subunit T1r3 or the signaling protein Trpm5 have greatly attenuated sweetener preferences but learn to prefer sucrose in 24-h tests. Here, we examined 24-h preferences of T1r3 KO, Trpm5 KO, and C57BL/6J wild-type (WT) mice for glucose, fructose, galactose, and corn starch. Unlike glucose, fructose has little postoral reward effect in WT mice, whereas conflicting data have been obtained with galactose. Naïve KO mice were initially indifferent to dilute glucose solutions (0.5–4%) but exhibited strong preferences for 8–32% concentrations. In a second test, they strongly preferred (~90%) all glucose concentrations although they drank less sugar than WT mice. Naïve KO mice were indifferent to 0.5–8% fructose and avoided 16–32% fructose. However, the glucose-experienced KO mice displayed significant preferences for all fructose solutions. Naïve KO mice preferred only 8% galactose, whereas WT mice preferred 4–16% galactose, and all mice avoided 32% galactose. Galactose experience enhanced the preference for this sugar in KO and WT mice. Naïve T1r3 KO and WT mice displayed similar preferences for 0.5–32% corn starch, which were enhanced by starch experience. Naïve Trpm5 KO mice did not prefer starch but did so after 1-bottle starch experience. The results confirm the sweet taste deficits of T1r3 KO and Trpm5 KO mice but demonstrate their ability to develop strong glucose and milder galactose preferences attributed to the postoral actions of these sugars. The acquired preference for the non-sweet flavor properties of glucose generalized to those of fructose. The findings further demonstrate that although Trpm5 (but not T1r3) signaling is essential for starch preference, Trpm5 KO mice can learn to prefer starch based on its postoral effects.
Quantifying Multiple Crystallite Orientations and Crystal Heterogeneities in Complex Thin Film Materials

Thin film materials have become increasingly complex in morphological and structural design. When characterizing the structure of these films, a crucial field of study is the role that crystallite orientation plays in giving rise to unique electronic properties. It is therefore important to have a comparative tool for understanding differences in crystallite orientation within a thin film, and also the ability to compare the structural orientation between different thin films. Herein, we designed a new method dubbed the mosaicity factor (MF) to quantify crystallite orientation in thin films using grazing incidence wide-angle X-ray scattering (GIWAXS) patterns. This method for quantifying the orientation of thin films overcomes many limitations inherent in previous approaches such as noise sensitivity, the ability to compare orientation distributions along different axes, and the ability to quantify multiple crystallite orientations observed within the same Miller index. Following the presentation of MF, we proceed to discussing case studies to show the efficacy and range of application available for the use of MF. These studies show how using the MF approach yields quantitative orientation information for various materials assembled on a substrate.
Does the impact of socioeconomic status on mortality decrease with increasing age

The impact of SES on mortality is an established fact. I examine if this impact decreases with increasing age. Most research finds that it does so but it is unknown whether this decrease is due to mortality selection. The data I use come from the US-Health and Retirement Study, which surveyed 9376 persons aged 59 and over from 1992 to 2000. The variables allow for a time varying measurement of SES, health and behavior. Event-history-analysis is applied to analyze differences in mortality rates. My results show that socioeconomic mortality differences are stable across ages whereas they clearly decline with decreasing health. My first finding, that health rather than age is the equalizer combined with the second finding, that good health itself is unequally distributed, leads to the conclusion that in old age, the impact of SES is transferred to the health status and hence it is stable across ages.
Electrodeposition of Sea Urchin and Cauliflower‐like Nickel‐/Cobalt‐Doped Manganese Dioxide Hierarchical Nanostructures with Improved Energy‐Storage Behavior

Transforming the existing Zn–MnO2 primary battery into a secondary battery with enhanced storage behavior and a low cost is of significant interest. Such technology could underpin future energy-storage development. To acquire this, doped electrolytic manganese dioxide (EMD) with hierarchical nanoarchitectures have been employed as a cathode in the Zn–MnO2 system. EMD is synthesized from manganese sulfate in a sulfuric acid bath with in situ doping of nickel and cobalt ions individually. Sea-urchin-shaped EMD has been obtained with nickel as a dopant, whereas cauliflower- and pyramidal-shaped hierarchical nanostructures are observed with cobalt as a dopant, using a facile galvanostatic method without employing any template or surfactant. The structural studies indicated that all EMD samples (in the absence and presence of dopants) are predominantly composed of gamma-type manganese dioxide; however, the peak intensity increased with increasing concentration of the dopants. The electrochemical results revealed that the Co-doped EMD composite played a crucial role in increasing the storage capacity of the Zn–MnO2 battery, whereas the Ni-doped EMD composite resulted in improved longevity compared the Co-doped and undoped counterparts. The EMD composites individually doped with Ni and Co resulted in improved storage behaviors of 395 and 670 mA h g−1, respectively, against the undoped sample which is 220 mA h g−1, implying that the presence of Co3O4 and mesoporous nanostructured surfaces enhanced the fast kinetics of electrochemical reactions.
CURATIVE EFFECT OF WOODFORDIA FRUTICOSA KURZ FLOWERS ON N- NITROSODIETHYLAMINE INDUCED HEPATOCELLULAR CARCINOMA IN RATS

Objective: To evaluate the antioxidant and anticancer effect of methanolic extract of Woodfordia fruticosa (MEWF) dried flowers on Nnitrosodiethylamine induced hepatocellular carcinoma in experimental rats. Methods: Six groups of six rats in each were selected for the study. Hepatocellular carcinoma was induced by the oral administration of NDEA (0.02%, 2ml, 5days/weeks) for 20 weeks to all groups except group I and VI. Group I animals treated as normal control and group VI served as drug control. After the intoxication with NDEA for 20 weeks, group III, IV and V animals were treated with daily doses of Silymarin and MEWF 100mg/kg, b.w and 200mg/kg, b.w respectively for 28 days. Serum and tissue biochemical analysis and immunohistochemical analysis were done to evaluate the antioxidant and anticancer effect of MEWF. Results: MEWF significantly (p ≤ 0.05) prevented the elevation of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) levels and reduced glutathione (GSH), glutathione-S-transferase (GST) and glutathione reductase (GR) levels. Immunohistochemical analysis revealed the overexpression of proliferating cell nuclear antigen (PCNA) and cyclin D1 in the liver tissue of rat intoxicated with NDEA. The over expression was effectively reduced by the treatment with MEWF. Conclusion: These results suggest the curative effect of MEWF against NDEA induced hepatocellular carcinoma and thus scientifically supports the use of this plant in traditional medicine for the treatment of liver cancer.
ELIMINATION OF HEAVY METALS (Cu, Zn, Cr, Ni and Pb) CONTAINED IN THE STABILIZED LEACHATE OF THE AGADIR LANDFILL BY PERCOLATION-INFILTRATION ON TITANIFEROUS MEDIUM

This study focuses on the treatment of heavy metals in the stabilized leachate of Agadir landfill by means of infiltration percolation technique on filters at different heights 0.5, 1 and 1.5 m filled with titaniferous medium (TFM). It also deals with the effectiveness of the TFM from the region of Agadir (Morocco) in the retention of heavy metals. Through this study, it appears that the leachate of the city is loaded with heavy metals (Zn, Cu, Cr and Pb) and that there is absence of Cadmium and Nickel. The comparison of the total concentration of these metals with the standards of discharge re-use revealed that the zinc, the chromium and the plumb, exceed the maximums recommended by the World Health Organization. The experimental device makes it possible to reduce the load in Zn, in Cr, in Cu and in Pb with interesting outcomes in proportional to the heights of the filters. For the 1.5 m height column, the abatement rates were respectively Cu, Zn, Cr and Pb at 58.25 %, 65.04 %, 69.62 % and 60.26 %. This treatment technique has shown significant purification performance in the removal of heavy metals in the leachate.
Docking studies of 1,5-disubtituted tetrazoles analogs of the anticancer drug imatinib as probable inhibitors of the ABL kinase and the T315I mutant kinase

A docking studies of a set of several 1,5-disubstituted tetrazoles (1,5-DS-T) compounds to find potential inhibitors of the Abelson tyrosine-protein kinase (ABL kinase) and the mutated ABL kinase T315I were conducted by using Lamarckian genetic algorithms as search algorithms in Autodock4. Bayesian calculations were performed, and specificity (Sp) and sensitivity (Se) values as well as positive predicted values (PPVs) and negative predicted values (NPVs) were calculated using a set of 99 active ligands and 385 decoys for ABL kinase from the DUD database. RMSD values were calculated between the X-ray crystallographically determined coordinates of the ligands in the complexes of ligand with the ABL kinase and with T315I ABL kinase resistant to imatinib. The predicted results showed the importance of the interactions of the protein with halogens present in some of these 1,5-DS-T ligands. In conclusion, the results suggest that eight novel 1,5-DS-T compounds were identified to be effective inhibitors of ABL kinase.