Miracle-dz/UniFAR-FTUs huggingface dataset:
Stem Cells for Retinal Degenerative Disorders

Abstract: Many systemic and eye‐specific genetic disorders are accompanied by retinal degenerations that lead to blindness. In some of these diseases retinal degeneration occurs early in life and is quite rapid, whereas in other disorders, retinal degeneration starts later and progresses very slowly. At present, no therapies are available to patients for preventing or reversing the retinal degeneration that occurs in these diseases. Implantation of neural progenitor cells into the eye may be a means by which to retard or even reverse degeneration of the retina. To evaluate the potential of neural precursor cell implantation for treating retinal degenerative disorders, neuralized mouse embryonic stem cells from green fluorescent protein (GFP) transgenic mice were administered intravitreally to normal mice, mice with early retinal degeneration, and mice with slowly progressing retinal degeneration. In normal mice, the donor cells remained in the vitreous cavity and did not associate with the host retina. In mice with early retinal degeneration, implantation of the neural precursors was performed after the degeneration was almost complete. In these animals, the donor cells primarily associated closely with the inner surface of the retina, although a small fraction of donor cells did integrate into the host retina. Donor cells implanted in mice with slowly progressing retinal degeneration also associated with the inner retinal surface, but many more of the cells integrated into the retina. These findings indicate the importance of host tissue‐donor cell interactions in determining the fate of implanted neural precursor cells. These interactions will be a major consideration when devising strategies for using cell implantation therapies for neurodegenerative disorders.
Unemployment Benefits, Contract Length and Nominal Wage Flexibility

We show in a union-bargaining model that a decrease in the unemployment benefit level increases not only equilibrium employment, but also nominal wage flexibility, and thus reduces employment variations in the case of nominal shocks. Long-term wage contracts lead to higher expected real wages and hence higher expected unemployment than short-term contracts. Therefore lower benefits reduce the expected utility gross of contract costs of a union member more with long-term than with short-term contracts and thus create an incentive for shorter contracts. Incentives for employers work in the same direction. Lower taxes associated with lower benefits also tend to make short-term contracts more attractive.
Capacity, Delay and Mobility in Hybrid Wireless Networks

The hybrid wireless network is the novel network model where a sparse network of base stations is placed within ad hoc networks, whose capacity is an important parameter to evaluate the network performance. In this paper, we establish a new hybrid network model of both static nodes and mobile nodes, which is more practical than the others in previous literatures. We propose the new routing policy based on the delay, which will assure the real-time transmission to some extent. We derive the analytical expression of mathematical expect value on the capacity in hybrid wireless networks, which is the main contribution of this paper.
The Effects of an Increase of Central Blood Volume Before Spinal Anesthesia for Cesarean Delivery: A Qualitative Systematic Review

We evaluated in this qualitative systematic review the efficacy of increasing central blood volume on the incidence of hypotension after spinal anesthesia for elective cesarean delivery. Randomized controlled trials investigating any method of increasing central blood volume before the initiation of obstetric spinal anesthesia were sought by using MEDLINE (1966–2000), Embase (January 1988–April 2000), and the Cochrane Library (Issue 1, 2000). Additional reports from retrieved and review articles, hand searching of non-MEDLINE journals, and abstracts of major anesthesia meetings (1994–1999) were located. The primary outcome was the incidence of hypotension. Secondary outcomes included: ephedrine use, Apgar scores, umbilical cord pH values, and maternal nausea and vomiting. Twenty-three articles met our inclusion criteria with the use of crystalloid preload, colloid preload, and mechanical methods of increasing central volume. Crystalloid preload was inconsistent in preventing hypotension, whereas colloid appeared to be effective in all but one study. Leg wrapping and thromboembolic stockings decreased the incidence of hypotension compared with leg elevation or control. Few differences in fetal outcomes or maternal nausea and vomiting were reported. Increasing central blood volume by using colloid and leg wrapping decreases but does not abolish the incidence of hypotension before spinal anesthesia for elective cesarean delivery.
Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3

The platelet P2Y12 receptor is the target of clopidogrel therapy, which has been shown to reduce thromboembolic complications of atherosclerotic disease but has limitations in terms of variability of response and irreversibility of effect. This receptor is also a target for ticagrelor (AZD6140), the first reversibly binding oral P2Y12 receptor antagonist that does not require metabolic activation and yields more consistent inhibition of platelet aggregation than clopidogrel therapy. Single nucleotide polymorphisms (SNPs) have been described in the gene for this receptor (P2RY12), some of which have been associated with variability in platelet reactivity. SNPs in P2RY1 and ITGB3 have also been reported by some groups to affect platelet reactivity to adenosine diphosphate (ADP). We assessed whether SNPs in these genes influenced the pharmacodynamic response to ticagrelor in patients enrolled in both the DISPERSE study (stable atherosclerotic disease) and the DISPERSE2 study (non-ST-segment elevation acute coronary syndromes). Platelet aggregation data (at baseline and 4 weeks) and DNA samples from clopidogrel-naive Caucasian patients treated with ticagrelor were available for 151 patients. Seventy four SNPs within three genes were genotyped. After adjustment for multiple comparisons, none of these SNPs were found to significantly influence inhibition of ADP-induced platelet aggregation by ticagrelor.
State estimation in power systems with FACTS devices and PMU measurements

This paper presents an algorithm for state estimation in power systems that include FACTS devices and PMUs. The FACTS devices are equipments of special purpose capable of changing the natural behavior of transmission systems. They may be able to influence the voltage, the active power or the reactive power flows based on predefined targets so that the classical power flow and steady state calculations must be adapted. Furthermore, PMU measurements are increasing in number so that the accuracy in steady state calculations can be improved. A state estimation algorithm was developed by considering the behavior of TCSC and SVC devices, while including some improvements due to the integration of synchronized measurements. A Matlab application was developed and simulations were performed on various test networks. In this paper, results obtained on the IEEE 30 bus test system only will be presented.
Hyperinflation in children with liver disease due to alpha‐1‐antitrypsin deficiency

Fifty‐nine patients (median age 6.0 years) with liver disease and ten healthy children without liver disease (median age 7.5 years) had serial measurements of functional residual capacity (FRC) over a period of at least 6 months. Twenty‐eight children with alpha‐1‐antitrypsin deficiency (A1ATD) tended to have higher lung volumes than 26 with extrahepatic biliary atresia (EHBA). Fifteen children had persistent hyperinflation (FRC > 120% predicted for height; 2 SD above the mean of controls); in five children (four with A1ATD) this was unresponsive to bronchodilator therapy. Two of the children with A1ATD who had persistent unresponsive hyperinflation on three serial measurements were only 3 and 4 years of age. No healthy child without liver disease was hyperinflated. These results suggest that A1ATD may be associated with lung function abnormalities even in very young children.
Introduction to genetic algorithms

The book contains basic concepts, several applications of Genetic Algorithms and solved Genetic Problems using MATLAB software and C/C++. The salient features of the book include - detailed explanation of Genetic Algorithm concepts, - numerous Genetic Algorithm Optimization Problems, - study on various types of Genetic Algorithms, - implementation of Optimization problem using C and C++, - simulated solutions for Genetic Algorithm problems using MATLAB 7.0, - brief description on the basics of Genetic Programming, - application case studies on Genetic Algorithm on emerging fields.
Propuesta y evaluación de un método extractivo de generación de resúmenes en el ámbito biomédico basado en conceptos

The methods for automatic summarization generation based in extractive techniques have widely shown its utility for his adaptability and efficiency in the manner of response time at any kind of application domain. In Biomedical field are numerous the research results about the overload information and the need of application of efficient recovery and summarization methods for the proper use of evidence based medicine. In this context we are going to present a proposal of methodology for automatic summarization based on structured knowledge and graph's use, applying similarity methods between phrases and considering concepts appearance frequency. Finally, a methodology’s evaluation is made to compare with other methods using the ROUGE tool and analyzing their results. Although the size of the evaluation set doesn’t allow extracting noteworthy conclusions, the results collected are enough promising to trust in the effectiveness of the proposal handed in.
High efficiency beam splitter for multifocal multiphoton microscopy

In this article we present the development of a multibeam two‐photon laser scanning microscope. A new type of beam splitter to create the multitude of laser beams is described. This type of beam splitter has higher transmission and generates more uniform beams than can be achieved with the microlens approach used by other groups. No crosstalk exists between the different foci due to small temporal delays between the individual beams. The importance of dispersion compensation to obtain maximum efficiency of the microscope is discussed. With optimum compensation the fluorescence signal was raised by a factor of 14. Different modes of detecting the fluorescence signals and their effect on imaging speed and resolution are discussed.
A new community detection based on agglomeration mechanism

Community detection is an important and hot research branch of complex network. The initial communities are essential for community detection, and the central nodes are the key points in the whole process. A few network measures are employed for node centrality, including betweenness and degrees centrality calculation. In our proposed algorithm both methods will be tested respectively for initial communities. Moreover, the agglomeration mechanism is employed for the proposed algorithm, and corresponding communities are achieved according to node membership function. Communities will be merged repeatedly based on the communities agglomeration rule until the defined number of communities is achieved. The proposed algorithm is tested on the three real network datasets, and it demonstrates the effectiveness and correctness of the algorithm.
The Effect of Carboxymethyl Cellulose on the Stability of Emulsions Stabilized by Whey Proteins under Digestion in vitro and in vivo

— In vitro gastro-duodenal digestion model was used to investigate the changes of emulsions under digestion conditions. Oil in water emulsions stabilized by whey proteins (2%) and stabilized by whey proteins (2%) with addition of carboxymethyl cellulose (0.75%) as gelling agent of continuous phase were prepared at pH7. Both emulsions were destabilized under gastric conditions; however the protective role of carboxymethyl cellulose was indicated by recording delay of fat digestibility of this emulsion. In the presence of carboxymethyl cellulose whey proteins on the interfacial surface of droplets were more resistant to gastric degradation causing limited hydrolysis of fat due to the poor acceptability of lipids for the enzymes. Studies of emulsions using in vivo model supported results from in vitro studies. Lower content of triglycerides in blood serum and higher amount of fecal fat of rats were determined when rats were fed by diet containing emulsion made with whey proteins and carboxymethyl cellulose.
Hybrid treatment of a post-EVAR aortoenteric fistula

This report presents a case of secondary aortoenteric fistula after endovascular aortic repair in a fragile patient: The fistula developed due to aneurysm shrinkage and remodeling of the stent graft, resulting in a kink eroding through the aneurysm wall into the duodenum. The aortoenteric fistula was successfully treated with a hybrid procedure with endovascular aortic repair, followed by open enteroraphy and omental flap coverage of the stent graft and local antibiotic irrigation. Despite the presence of the stent graft in a previously infected field, the patient has recovered from the acute event with no septic recurrence or hemorrhage during four years of follow-up.
Extracellular Adenosine 5'-ATP-induced Calcium Signaling in Isolated Vestibular Ganglion Cells of the Guinea Pig

Extracellular adenosine 5'-triphosphate (ATP)-induced intracellular calcium concentration ([Ca2+]i) changes in acutely isolated vestibular ganglion cells (VGCs) of the guinea pig were investigated using the Ca2+-sensitive dye Fura-2. Extracellular ATP induced an increase in [Ca2+]i in VGCs in a dose-dependent manner. ATP induced an increase in [Ca2+]i even in the absence of extracellular Ca2+ (1 mM Ethylene Glycol-bis (
Melanoma—Part 1: epidemiology, risk factors, and prevention

#### Summary points The incidence of melanoma has risen over the past 30 years in most white populations.1 2 However, in some parts of the world incidence rates are stable or falling. Although large scale primary prevention programmes such as public health education campaigns aimed at reducing exposure to sun may lead to reduced incidence, such programmes have not yet been proved effective. However, melanoma is highly amenable to secondary prevention through early detection. Being able to recognise a melanoma early is an important skill for primary healthcare practitioners. In this first article of a two part series on melanoma, we examine the evidence on the genetic epidemiology of melanoma and outline the complex interactions between incidence, mortality, and survival trends; we also discuss the evidence for prevention. Although melanoma remains a relatively rare tumour, many European countries show an annual increase in incidence above 2%; in some northern European countries, however, no significant increase has been observed.1 Between 1992 and 2005, the annual increase in incidence rates of melanoma in the United States was 2.3% for all races and 2.8% in white populations.3 Queensland in Australia had an increase in incidence of 1.4% for males and 0.7% for females during 1982 to 2001.4 Most recent incidence data show that in some …
Proteomic technologies for the identification of disease biomarkers in serum: Advances and challenges ahead

Serum is an ideal biological sample that contains an archive of information due to the presence of a variety of proteins released by diseased tissue, and serum proteomics has gained considerable interest for the disease biomarker discovery. Easy accessibility and rapid protein changes in response to disease pathogenesis makes serum an attractive sample for clinical research. Despite these advantages, the analysis of serum proteome is very challenging due to the wide dynamic range of proteins, difficulty in finding low‐abundance target analytes due to the presence of high‐abundance serum proteins, high levels of salts and other interfering compounds, variations among individuals and paucity of reproducibility. Sample preparation introduces pre‐analytical variations and poses major challenges to analyze the serum proteome. The label‐free detection techniques such as surface plasmon resonance, microcantilever, few nanotechniques and different resonators are rapidly emerging for the analysis of serum proteome and they have exhibited potential to overcome few limitations of the conventional techniques. In this article, we will discuss the current status of serum proteome analysis for the biomarker discovery and address key technological advancements, with a focus on challenges and amenable solutions.
Korelasi antara self monitoring dan customer orientation pada perawat di rumah sakit

This research aimed to know the correlation between self monitoring and customer orientation. The hypothesis was there was a positif correlation between self monitoring and customer orientation. The subject were 84 nurses who had work experience in hospital minimized one year. The data about self monitoring was revealed by the adaptation of self monitoring scale with the reliability 0,896 and, customer orientation was revealed by the adaptation of customer orientation scale with the reliability 0,886. The result were shown that correlation coefficient of self monitoring and customer orientation was 0,842, p = 0,000 (p < 0,05), that means there was a positif and strong correlation between self monitoring and customer orientation at 5% significant level. Keyword : self monitoring and customer orientation PLAGIAT MERUPAKAN TINDAKAN TIDAK TERPUJI PLAGIAT MERUPAKAN TINDAKAN TIDAK TERPUJI
Citation indexes for science.

Eugene Garfield's article, " Citation indexes for science " [Science 122, 108 (1955)], is interesting beyond doubt. If we had in our library a citation index such as he proposes, I should use it to advantage. Amid today's overwhelming difficulties in scientific communication, however, this index would solve too few problems to justify its surely great cost at this time. Even though all the cited references in a given article were indexed, those ideas and key words not covered by the cited references (would remain excluded, according to Garfield's system. The most a \' 61 3 (S56 valuable parts of a research paper, the author's own contributions, would fare no better than they do today. thus In our present indexing journals, many key words are not mdexed at all; a paper's title-and even its summary-often can display only a few of the author's ideas. Excellent thoughts, particularly concem-#ing technique, may lie buried deep within an article, lost to the index-reading " public. " It is precisely the inventive, busy author who will neglect to publish a significant idea in the form of a separate Pa per. A citation index, much as it may be worthwhile, would fail to catch and broadcast such an idea. My suggestion in regard to literature indexing would be to continue and Lqeatly expand the sort of skilled, discriminating indexing that is. found in the Armed Forces Medical Library's Current List of Medical Literature and in Chemical Ah-stracts, publications that are excellent despite their limited budgets. The status of the Armed Forces Medical Library should be changed to that of an independent Federal Medical Information Bureau. Chemical Abstracts and similar publications should be supported in part by the government. Congress should appropriate a truly adequate sum of money to provide these organizations-with highly trained indexing personnel (minimal education: M.S. degree). An impractical dream? All right; but this sort of action, which would conform to the Hoover Commission's recommendation for greater support of,basic medical re.search (Phikdelphiu Inquirer, 1 July 1955) is just what is needed to begin the attack on our massive problem of scientific communication. Other subsequent efforts in this direction would include the formation of an International Scientific Journal Union (to supervise prompt publication) and the development of departmentalized scientific newspapers as reported by J. A. If the cost of preparing a cita tion index were comparable to the cost of conventional indexes, this cost …
Transcription termination and the regulation of gene expression.

INTRODUCTION 339 STRUCTURAL FEATURES OF TERMINATION SITES . 340 Prokaryotes . 341 Eukaryotes 346 FACTORS THAT REGULATE TERMINATION EFFI CIENCY AND LOCATION. 350 Prokaryotes . 350 Eukaryotes 356 MECHANISTIC AND STRUCTURAL CONSIDERATIONS. 359 The Dynamics of Terminati on 359 Mechanisms: Similarities and Diff erences . 361 SUMMARY, CONCLUSIONS, AND QUE STIONS FOR THE FUTURE 363
Active B12: a rapid, automated assay for holotranscobalamin on the Abbott AxSYM analyzer.

BACKGROUND Conventional tests for vitamin B(12) deficiency measure total serum vitamin B12, whereas only that portion of vitamin B12 carried by transcobalamin (holotranscobalamin) is metabolically active. Measurement of holotranscobalamin (holoTC) may be more diagnostically accurate for detecting B(12) deficiency that requires therapy. We developed an automated assay for holoTC that can be used on the Abbott AxSYM immunoassay analyzer. METHODS AxSYM Active B12 is a 2-step sandwich microparticle enzyme immunoassay. In step 1, a holoTC-specific antibody immobilized onto latex microparticles captures holoTC in samples of serum or plasma. In step 2, the captured holoTC is detected with a conjugate of alkaline phosphatase and antiTC antibody. RESULTS Neither apoTC nor haptocorrin exhibited detectable cross-reactivity. The detection limit was < or = 0.1 pmol/L. Within-run and total imprecision (CV ranges) were 3.4%-5.1% and 6.3%-8.5%, respectively. Assay CVs were < 20% from at least 3 pmol/L to 107 pmol/L. With diluted serum samples, measured concentrations were 104%-114% of the expected values in the working range of the assay. No interference from bilirubin, hemoglobin, triglycerides, erythrocytes, rheumatoid factor, or total protein was detected at expected (abnormal) concentrations. A comparison of the AxSYM Active B12 assay with a commercial RIA for holoTC yielded the regression equation: AxSYM = 0.98RIA + 4.7 pmol/L (S(y x), 11.4 pmol/L; n = 204). Assay throughput was 45 tests/h. A 95% reference interval of 19-134 pmol/L holoTC was established with samples from 292 healthy individuals. CONCLUSIONS The AxSYM Active B12 assay allows rapid, precise, sensitive, specific, and automated measurement of human holoTC in serum and plasma.