Miracle-dz/UniFAR-FTUs huggingface dataset:
A new relaxed mutant of Bacillus subtilis

A new relaxed mutant of Bacillus subtilis was isolated by screening Rifr clones for alterations in stringent control. The Rifr relaxed mutant which is described was found to contain a second-site mutation conferring a relaxed response to an energy source downshift and was partially relaxed after amino acid starvation. The new rel locus, called relG, was distinct from the two other known rel loci in B. subtilis, relA, and relC.
Do public sector industrial relations challenge the Swedish model?

Abstract This article discusses recent developments in public sector labour relations in Sweden from a historical, gender and power relations perspective. The main question is whether these trends challenge the established Swedish industrial relations system. Our point of departure – yet chronologically also the point of arrival – is the Swedish Municipal Workers’ Union, Kommunal’s, exit from the coordinated wage setting model within the Swedish Trade Union Confederation (Landsorganisationen, LO) in 2015/2016. The immediate reason was that Kommunal, representing one-third of the LO members, including many low-paid women, turned down the LO’s proposal on a general wage increase for low-wage groups. Instead, Kommunal urged to upgrade wages for a specific member group, the auxiliary nurses. This broke an almost uninterrupted 20-year-long period of labour market cooperation and coordination that was introduced in 1997 through the so-called Industry Agreement (Industriavtalet). This agreement was launched in the wake of the deep financial crisis in the early 1990s, and the neoliberal move towards a complete decentralization of pay negotiations. How should this move by Kommunal be interpreted? Why, and when, has the centralized system become a straitjacket for Kommunal, when for decades it seemingly was a precondition for both private and public union strength?
Performance investigation of dual band millimetre wave SiGe low noise amplifier (LNA)

SiGe HBT technology transistor provides performance comparable with III-V technologies along with the processing maturity and integration levels commonly associated with Si technology. The present work utilizes 130nm SiGe HBT transistors to investigate the performance of low noise amplifier (LNA) for 40GHz and 60GHz wireless personal area networks (WPANs). The transfer gain S2i was found >9dB with 3-dB bandwidth (BW)>5GHz in the bands of interest. Excellent simultaneous matching at input (S11≤-20dB) and output (S22≤-10dB) with noise figure (NF)<;2.5dB at both the bands were obtained. Theoretically, predicted S-parameters of the LNA were found closely matched with corresponding simulated results. The input third-order intercept (IIP3) was found > 3.0dBm in the bands of interest. The graph of performance ratio (R=S21/PDC) versus noise factor F gives significant advantage for SiGe HBT LNA (i.e. achieve high R at low F) as compared to GaAs HBT and Si CMOS technologies. A new figure-of-merit (FoM) involving S2i, noise factor F, IIP3 and power consumption PDC was found to be significantly higher for SiGe LNA than a previously published experimental result for silicon CMOS LNA.
Presence of Banks on Social Networks in Bosnia and Herzegovina

Abstract Background: Social networks allow real-time interaction that enhances a bank’s ability to respond to customers in a timely, intuitive and personalized manner. By using social networks, banks can improve the understanding of their clients and bank’s products they need. Also, banks can enhance relations with clients and strengthen their brand through raising client loyalty. Objectives: The paper explores and analyses the current presence of banks in Bosnia and Herzegovina on social networks. Methods/Approach: The paper studies the presence of 24 banks in Bosnia and Herzegovina on social networks and analyses the basic characteristics of profiles/pages of the banks on the most popular social networks. Results: A half of the banks have their profiles/pages on different social networks (mostly on Facebook and YouTube). They use the profiles/pages mainly for content marketing, i.e. for presenting their business operations. Unfortunately, banks do not encourage interaction with clients, except through likes. Conclusions: The analysis does not show that banks have a systematized and planned appearance on social networks. There is a plenty of room for improvement, and it is necessary primarily to address the interaction between clients and banks through social networks.
A community based interoperability utility for SMEs

In Europe, more than 19 million companies are Small and Medium size Enterprises (SMEs), representing 99.8% of all registered businesses, making the European economy depend upon their contribution to wealth creation and employment. Although SMEs have some strong advantages in flexibility and responsiveness, they struggle to compete for large projects where efficient and effective collaborations are required. Enterprise interoperability has been addressed by research for decades without real success as well as having little impact on SMEs. Consequently the market still lacks an affordable, easy to integrate solution. Instead, SMEs face costly investment, extensive integration effort and significant revision of their working tools and systems. One of the main challenges addressed by our research is to support SMEs with an (almost) zero cost of entry into interoperability, based on non-proprietary protocols, allowing these enterprises to reuse existing and familiar applications such as e-mail. This paper introduces such an interoperability solution for SMEs.
Sustainable Development Goal 5: How Does the Philippines Fare on Gender Equality?

The global goal to attain gender equality, including ending all forms of discrimination against women and girls, and ensuring their safety, is central to the achievement of the Sustainable Development Goals. Its attainment means that every person, regardless of sex, is empowered to reach their full potential. This entails having both men and women given equal opportunities to education, paid employment, and real decisionmaking power whether in private or public sectors. This paper discusses how the country fares in several gender-related indicators that can be used to monitor progress toward gender equality and women empowerment. It provides an overview of the current situation in areas such as equality of human capabilities, equality of economic opportunity, equality in political voice and leadership, and the safety of women and girls. The paper also identifies priorities for public policy while seeking new directions in addressing several transformational issues to attain gender equality and women empowerment in the country.
Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy.

BACKGROUND External beam radiotherapy is standard treatment for medium and large, or visually threatening, intraocular retinoblastoma but markedly increases the risk of cosmetic deformities and second malignant neoplasms in children with germline RB1 mutations. Large tumors and those with vitreous seeds do poorly despite radiotherapy. Chemotherapy traditionally is ineffective for intraocular retinoblastoma, perhaps because many retinoblastomas overexpress the multidrug resistance protein, P-glycoprotein. OBJECTIVE To avoid radiotherapy in the management of intraocular retinoblastoma by using chemotherapy and focal therapy. INTERVENTIONS We shrank retinoblastomas in 40 eyes of 31 patients that conventionally should be enucleated or receive radiotherapy by using chemotherapy (ie, vincristine-teniposide, 8 eyes; additional carboplatin, 32 eyes) combined with the administration of cyclosporine, a known multidrug-resistance-reversal agent. We then consolidated these responses to chemotherapy by subsequent 532- and 1064-nm laser therapy and cryotherapy. RESULTS At the median follow-up of 2 2/3 [corrected] years (range, 1/10-4 3/4 years), the results of treatment were excellent. The actuarial relapse-free rate was 89% in patients not previously treated (91% for 28 eyes) and 67% in patients treated after relapse from previous therapy (70% for 12 eyes). For the eyes with the worst prognosis (ie, vitreous seeds), the relapse-free rate was 88%, better than previously reported. Cyclosporine is nontoxic and did not enhance the expected toxic effects of chemotherapy. Most eyes required laser therapy, cryotherapy, or both for consolidation of tumor control. CONCLUSIONS This pilot study suggests that most retinoblastomas are curable by combining chemotherapy with cyclosporine therapy, laser therapy, and cryotherapy, without requiring external beam radiotherapy. We propose a randomized trial to clarify the role of cyclosporine.
Macro-economic coordination and elusive ownership in the European Union

Department of Political Science, Université libre de Bruxelles, Brussels, Belgium Correspondence Amandine Crespy, Department of Political Science, Université libre de Bruxelles, Avenue F. D. Roosevelt 50, Brussels 1000, Belgium. Email: acrespy@ulb.ac. be Funding information European Commission Project Number: 649456 The notion of ownership is well known in relation to global governance. In the realm of EU macro-economic coordination, it has become a buzzword since the revamping process of the European Semester in 2015. This article investigates how ownership by four types of domestic actors (governments, administrations, parliaments and social partners) manifests itself in the European Semester. We conceptualize three types of ownership, namely institutional, political, and cognitive. Using network analysis, semistructured interviews, and a small-scale survey, we find that ownership is strongest among governments and administrations which are able to shape the outputs of the European Semester (institutional ownership) with little political disagreement (political ownership). While national parliaments display low levels of all types of ownership, employers and unions exhibit relatively strong cognitive ownership. We conclude that the European Semester remains a bureaucratic process contributing to building a multi-level administrative space rather than an arena for political debates.
Genotypic Changes in Human Immunodeficiency Virus Type 1 Associated with Loss of Suppression of Plasma Viral RNA Levels in Subjects Treated with Ritonavir (Norvir) Monotherapy

ABSTRACT Ten subjects received 600 to 1,200 mg of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor ritonavir per day. Following 2 weeks of therapy, plasma HIV RNA levels decreased by a mean of 1.57 (range, 0.89 to 1.96) log units. With continued therapy, HIV RNA levels began to rise in eight subjects. The initial rise in plasma RNA levels was temporally associated with the development and quantitative increase in the V82 resistance mutation. Doubling times of the V82A mutant virus were estimated to be 2.4 to 4.8 days. An L63P/A mutation was commonly present at baseline even in subjects with a durable virologic response. The concomitant acquisition of an L63P/A mutation with the V82A/F mutation at the time when plasma RNA levels rebounded suggests a role for the L63P/A mutation in improving the fitness of the V82A/F mutation. Subsequent additional genotypic changes at codons 54 and 84 were often associated with further increases in plasma RNA levels. Ongoing viral replication in the presence of drugs resulted in the appearance of additional genotypic changes, including the L90M saquinavir resistance mutation, and decreased phenotypic susceptibility. The relative fitness of the protease V82A ritonavir resistance mutation and reverse transcriptase T215Y/F zidovudine resistance mutation following drug withdrawal were estimated to be 96 to 98% that of the wild type. Durability of the virologic response was associated with plasma RNA levels at the nadir. A virologic response beyond 60 days was not observed unless plasma HIV RNA levels were suppressed below 2,000 copies/ml, consistent with estimates from V82A doubling times for selection of a single resistance mutation to dominate the replicating population.
Identification of a Conserved Chromosomal Region Encoding Klebsiella pneumoniae Type 1 and Type 3 Fimbriae and Assessment of the Role of Fimbriae in Pathogenicity

ABSTRACT Type 3 fimbriae are expressed by most clinical Klebsiella pneumoniae isolates and mediate adhesion to host structures in vitro. However, the role of type 3 fimbriae in K. pneumoniae virulence has not been evaluated by use of in vivo infection models. In this study, the type 3 fimbrial gene cluster (mrk) of the clinical isolate C3091 is described in detail. The mrk gene cluster was revealed to be localized in close proximity to the type 1 fimbrial gene cluster. Thus, a 20.4-kb fimbria-encoding region was identified and found to be highly conserved among different K. pneumoniae isolates. Interestingly, a homologue to PecS, known as a global regulator of virulence in Erwinia chrysanthemi, was identified in the fimbria-encoding region. Comparison to the previously characterized plasmid encoded mrk gene cluster revealed significant differences, and it is established here that the putative regulatory gene mrkE is not a part of the chromosomally encoded type 3 fimbrial gene cluster. To evaluate the role of type 3 fimbriae in virulence, a type 3 fimbria mutant and a type 1 and type 3 fimbria double mutant was constructed. Type 3 fimbria expression was found to strongly promote biofilm formation. However, the fimbria mutants were as effective at colonizing the intestine as the wild type, and their virulence was not attenuated in a lung infection model. Also, in a urinary tract infection model, type 3 fimbriae did not influence the virulence, whereas type 1 fimbriae were verified as an essential virulence factor. Thus, type 3 fimbriae were established not to be a virulence factor in uncomplicated K. pneumoniae infections. However, since type 3 fimbriae promote biofilm formation, their role in development of infections in catheterized patients needs to be elucidated.
Cerebral Cortical Localization: Application and Validation of the Proportional Grid System in MR Imaging

The Talairach stereotactic proportional grid method for telencephalic localization was applied to magnetic resonance imaging of 30 brain hemispheres of healthy adult volunteers. Using sagittal images, outlines of the following characteristic principal sulci were identified on the brain surface to validate the method: callosal sulcus, parietooccipital sulcus, marginal sulcus, superomedial portion of central and postcentral sulcus, and posterior sylvian fissure. The maximal variation zones of sulcus location obtained by superim-position of the individual grid data on a standard proportional grid were similar to those originally reported by Talairach from pneumoencephalographic studies. However, the central sulcus, which was only studied postmortem by Talairach, was located 0.5–1 cm more posteriorly in the present study. Magnetic resonance also provided more detailed data on the considerable variation of the terminal parts of the sylvian fissure and on the well-known left-right asymmetries. The left sylvian fissure extended farther posteriorly in 11 of 15 brains. With the exception of this posterior perisylvian region, the proportional grid proved to be valid for indirect cerebral cortical localization in the regions studied.
Dopant Segregation and Nickel Stanogermanide Contact Formation on $\hbox{p}^{+} \hbox{Ge}_{0.947}\hbox{Sn}_{0.053}$ Source/Drain

P<sup>+</sup>Ge<sub>1-x</sub>Sn<sub>x</sub> is a promising source and drain (S/D) stressor material for Ge p-MOSFETs, and an S/D material in Ge<sub>1-x</sub>Sn<sub>x</sub> channel p-MOSFETs. In this paper, we investigate the dopant segregation (DS) effects in the stanogermanidation of p<sup>+</sup>Ge<sub>0.947</sub>Sn<sub>0.053</sub> (boron-doped). A study comparing the contact resistance <i>R</i><sub>C</sub> of nickel stanogermanide [Ni(Ge<sub>1-x</sub>Sn<sub>x</sub>) or Ni(GeSn)] contact on p<sup>+</sup>Ge<sub>1-x</sub>Sn<sub>x</sub> and nickel germanide (NiGe) contact on p<sup>+</sup> Ge was performed. A more pronounced DS effect is achieved during the stanogermanidation in comparison with the NiGe/p<sup>+</sup>Ge control. <i>R</i><sub>C</sub> is 44% lower in the Ni(Ge<sub>1-x</sub> Sn<sub>x</sub>)/p<sup>+</sup>GeSn structure as compared to the NiGe/p<sup>+</sup>Ge control. The reduced <i>R</i><sub>C</sub> is attributed to a more significant DS effect and the lower bandgap of Ge<sub>1-x</sub>Sn<sub>x</sub> as compared with Ge.
Crossing the line: what counts as online harassment?

Aguilar de la Cámara Hispana espera continuar trabajando en la Comisión Portuaria See AGUILAR Page 2 By Rhashad R. Pittman It may be Stockton’s most valuable asset in terms of economic impact, yet the Port of Stockton remains out of mind and nearly out of sight for most residents in the region. If you asked around, most people probably would never imagine that $1.5 billion worth of cargo float in and out of the port each year, to and from countries all over the world. The Port of Stockton’s role in the local economy is critical to say the least. No one knows that more than the seven men and women who serve on the Port’s governing body, the Port Commission. One of those Commissioners is businessman Sylvester Aguilar. Having served nearly a full fouryear term, Aguilar is up for reappointment by the Stockton City Council and hopes to serve another term. Being reappointed to the Commission of the Port of Stockton would be an honor, he said, and would allow him to continue to give back to the city he loves. “I am humbled to have been a part of the economic recovery of Stockton and the Central Valley and look forward to continuing our efforts to bring new industries and more jobs to our great city,” Aguilar said. “While I admit there was a steep learning curve, I have truly been able to make a difference and feel very good about my success in
An approach to develop location-based efficiency systems without real test drives

The development of intelligent vehicle systems based on non-deterministic input signals of the environment, have a dramatically increased complexity. Real test drives are no longer adequate to cover all test-cases, due to costs and complexity. One way to meet this challenge is a simulated test drive. In this case the driver, the environment and the vehicle are described within simulation models. Scenarios can be reproduced exactly. Tests can be executed automatically. Based on realistic road networks, realistic positioning data can be simulated. This allows development and testing of location-based systems. Especially for electric vehicles location-based systems are of great importance. We developed a simulation framework which represents the three domains (vehicle, driver and environment) within a closed-loop simulation. Using the framework we are able to execute simulated test-drives. In order to confirm the significance of the simulated test drive for the development, we validate the quality of the simulation results with data recorded on an electric vehicle fleet test. The architecture enables to reproduce a real test drive within a closed loop simulation.
A Policy and Environmental Response to Overweight in Childhood: The Impact of Gold Medal Schools

Background The prevalence of overweight among US children and adolescents has increased substantially since 1980. As a result, overweight in childhood and adolescence has become a substantial health problem that requires effective health promotion programs and interventions. Context Coinciding with the 2002 Winter Olympic Games in Salt Lake City, the Utah Department of Health (UDOH) developed a pilot program called Gold Medal Schools (GMS) to promote healthy lifestyles among school-aged children. Methods The GMS program was designed to help schools develop policies and create healthy school environments to meet specific criteria at 5 levels: bronze, silver, gold, platinum, and platinum focus. Participating schools, mentored by the UDOH, earn incentives to create a healthy school environment. Consequences A total of 316 schools and approximately 166,600 students in 37 Utah school districts have participated in the GMS program. As a result, 1,029 medals have been awarded, 2,205 policies have been developed, and 2,121 environmental changes have been reported since program inception (2001-2002 school year). Interpretation Because of their participation in the GMS program, schools have developed and implemented a wide range of school-based policies and environmental changes. To improve the program, we recommend enhanced efforts in impact and outcome evaluation and increased participation in vigorous-intensity physical activity during the school day.
Enhanced Interferon Signaling Pathway in Oral Cancer Revealed by Quantitative Proteome Analysis of Microdissected Specimens Using 16O/18O Labeling and Integrated Two-dimensional LC-ESI-MALDI Tandem MS*

Oral squamous cell carcinoma (OSCC) remains one of the most common cancers worldwide, and the mortality rate of this disease has increased in recent years. No molecular markers are available to assist with the early detection and therapeutic evaluation of OSCC; thus, identification of differentially expressed proteins may assist with the detection of potential disease markers and shed light on the molecular mechanisms of OSCC pathogenesis. We performed a multidimensional 16O/18O proteomics analysis using an integrated ESI-ion trap and MALDI-TOF/TOF MS system and a computational data analysis pipeline to identify proteins that are differentially expressed in microdissected OSCC tumor cells relative to adjacent non-tumor epithelia. We identified 1233 unique proteins in microdissected oral squamous epithelia obtained from three pairs of OSCC specimens with a false discovery rate of <3%. Among these, 977 proteins were quantified between tumor and non-tumor cells. Our data revealed 80 dysregulated proteins (53 up-regulated and 27 down-regulated) when a 2.5-fold change was used as the threshold. Immunohistochemical staining and Western blot analyses were performed to confirm the overexpression of 12 up-regulated proteins in OSCC tissues. When the biological roles of 80 differentially expressed proteins were assessed via MetaCore™ analysis, the interferon (IFN) signaling pathway emerged as one of the most significantly altered pathways in OSCC. As many as 20% (10 of 53) of the up-regulated proteins belonged to the IFN-stimulated gene (ISG) family, including ubiquitin cross-reactive protein (UCRP)/ISG15. Using head-and-neck cancer tissue microarrays, we determined that UCRP is overexpressed in the majority of cheek and tongue cancers and in several cases of larynx cancer. In addition, we found that IFN-β stimulates UCRP expression in oral cancer cells and enhances their motility in vitro. Our findings shed new light on OSCC pathogenesis and provide a basis for the future development of novel biomarkers.