Miracle-dz/UniFAR-FTUs huggingface dataset:
Resilience as a moderator of the indirect effects of conflict and workload on job outcomes among nurses

AIM To examine the relative effects of interpersonal conflict and workload on job outcomes (turnover intentions, burnout, injuries) and examine if resilience moderates the indirect effects of conflict and workload on job outcomes via job-related negative effect. BACKGROUND There is interest in understanding resilience in the nursing profession. Placing resilience in the context of the Emotion-Centred Model of Occupational Stress (Spector, ) is a novel approach to understanding how resilience ameliorates the negative effects of workplace stressors. DESIGN This study used a two-wave survey design to collect data from 97 nurses across medical units. METHODS Nurses working in the US were recruited in June 2014 using Qualtrics Panels, an online survey platform service that secures participants for research. Nurses were contacted via email at two time points, two weeks apart and provided a link to an online survey. SPSS v. 23 and PROCESS v2.15 were used to analyse regressions and moderated mediation. RESULTS/FINDINGS Interpersonal conflict predicted turnover intentions and burnout; workload predicted injuries. Job-related negative affect mediated the relationships between stressors and job outcomes except for the direct effect of workload on injuries. Low resilience increased the magnitude of the indirect effects of conflict on job outcomes. CONCLUSION Job characteristics like workload predicted unique variability in self-reported physical injuries. Conflict at work, a social stressor, predicted well-being and job attitudes. Highly resilient nurses bounced back after experiencing conflict in the workplace. Resilience should be explored for its potential as a method to reduce the negative effects of social stressors.
Monitoring AMS Simulation: From Assertions to Features

The complexity of analog mixed-signal (AMS) designs motivates the designers to analyze these systems in terms of features, which can be defined as the characterizing behavioral attributes of the designs. The first step towards automating the evaluation of feature values is to express the feature definitions in a formal way, and then to evaluate them over behavioral signatures. In this paper we present a framework for evaluating feature values over standard simulation platforms. Case studies over several circuit families are presented to illustrate the proposed methodology.
Structural reaction pattern of hepatocytes following exposure to hypotonicity

Isolated rat hepatocytes were exposed to hypotonic media (225 mosmol/l) for 5 and 15 min and processed for a quantitative electron microscopic stereologic analysis. Within 5 min of hypotonicity, the hepatocyte volume increased by 25% and thereatter displayed a volume regulatory decrease leading to mean cellular volume, which was 16% above that of controls. Stereologic analysis of the major subcellular compartment, the cytosol, showed an identical change as the whole cell. In contrast to that, the mitochondrial compartment increased in volume by 30% within the first 5 min of exposure and returned by regulatory volume decrease back to values of the isotonic controls after 15 min of hypotonicity. In contrast, hypotonicity (220 mosmol/l)‐stimulation of flux through mitochondrial glutaminase and the glycine cleavage enzyme complex, as assessed by 14CO2 production from [1‐14C]glutamine or [1‐14C]glycine in isolated perfused rat liver persisted throughout a 15‐min period of hypotonic exposure. Thus hypotonicity‐induced alterations of mitochondrial metabolism apparently do not parallel the time course of mitochondrial volume changes. This suggests that persistent mitochondrial swelling is not required for functional alterations, but that the latter may be triggered by the initial swelling of mitochondria. Hypotonic exposure did not alter the nuclear volume of isolated hepatocytes. Cell membrane surface nearly doubled after 5 min of hypotonic exposure, but returned within 15 min of exposure to values observed in normotonic media. This may reflect the participation of exocytosis in hepatocyte volume regulation. © 1993 Wiley‐Liss, Inc.
Information Integration of Drug Discovery and Clinical Studies to Support Complex Queries Using an Information Supply Chain Framework

Query support of frameworks which are capable of linking and integrating trusted information in disciplines such as clinical studies face many challenges, as usually data are neither semantically consistent nor in a form which can be easily extracted and shared. Drawing conclusions from clinical studies usually requires integrating data from various sources at various time points and inferring facts from an integrated information set. However, relevant information may not be present at all or not in sufficient detail or quality to support a particular query. In this paper, we present an approach for query support in integrating diverse information sources and how trust can be strengthened in using subject oriented specific Information Supply Chains (ISC). We assess feasibility of query support in an ISC framework using an underlying Information Dependency Relation Model for relevant information sources and how such a framework may facilitate collaboration in supplying information at the right time and with required quality.
Lessons learned from human HIV vaccine trials

Purpose of review The ability to induce broadly neutralizing antibody (bNAb) responses is likely essential for development of a globally effective HIV vaccine. Unfortunately, human vaccine trials conducted to date have failed to elicit broad plasma neutralization of primary virus isolates. Despite this limitation, in-depth analysis of the vaccine-induced memory B-cell repertoire can provide valuable insights into the presence and function of subdominant B-cell responses, and identify initiation of antibody lineages that may be on a path towards development of neutralization breadth. Recent findings Characterization of the functional capabilities of monoclonal antibodies isolated from a HIV-1 vaccine trial with modest efficacy has revealed mechanisms by which non-neutralizing antibodies are presumed to have mediated protection. In addition, B-cell repertoire analysis has demonstrated that vaccine boosts shifted the HIV-specific B-cell repertoire, expanding pools of cells with long third heavy chain complementarity determining regions – a characteristic of some bNAb lineages. Summary Detailed analysis of memory B-cell repertoires and evaluating the effector functions of isolated monoclonal antibodies expands what we can learn from human vaccine trails, and may provide knowledge that can enable rational design of novel approaches to drive maturation of subdominant disfavored bNAb lineages.
Prevalence of Pseudoexfoliation Syndrome in Turkish Patients with Senile Cataract

Abstract Purpose: To investigate the prevalence of pseudoexfoliation syndrome (PEX) among Turkish patients with senile cataract. Materials and Methods: Records of 352 eyes of 352 patients who underwent cataract surgery were analyzed in this retrospective study. The presence of PEX, type of cataract, intraocular pressure (IOP), glaucoma, age-related macular degeneration, and systemic diseases (coronary artery disease, hypertension, diabetes mellitus) were recorded. Results: The overall prevalence of PEX syndrome was detected to be 11%. The mean age of PEX patients was significantly higher than without PEX (74.4 ± 7.2 years and 69.3 ± 11.4 years, respectively, p = 0.004). The most common cataract type in the PEX patients was mixed-type cataract determined in 51.2% of patients. IOP was significantly higher in eyes with PEX than in eyes without it (16.1 ± 4.5 mmHg and 14.7 ± 3.8 mmHg, respectively; p = 0.03). Moreover, the prevalence of age-related macular degeneration was found to be significantly higher, and prevalence of glaucoma slightly higher in PEX patients than without PEX. Conclusion: Pseudoexfoliation syndrome is a common condition in Turkish people. PEX is associated with mixed type of cataract, age-related macular degeneration, and elevated IOP. Therefore, PEX patients should be checked for concomitant diseases.
Forecasting Foreign Institutional Investment Flows towards India Using ARIMA Modelling

India has witnessed substantial increase in capital flows, particularly Foreign Institutional Investment in equity as well as derivatives segment since the 1990s. However, FII flows are sighted as ‘hot money’- more volatile than other type of flows, which gets affected by the domestic and global- macro economic factors, thereby raising questions about the need to encourage FII flows in narrow and shallow (in terms of absorption capacity) capital market such as India. This paper attempts to forecast daily Aggregate FII flow in Indian Capital market and particularly in Futures Market (Derivative Segment) using Auto Regressive Integrated Moving Average (ARIMA) model.The paper tries to examine FII flows in India towards futures market along with spot market by tracing which AR terms and/or MA terms influence the current inflow or outflow.
Early onset periodontitis: A comparison and evaluation of two proposed modes of inheritance

Two rare types of familial periodontitis, a localized form usually diagnosed in late adolescence, and a more generalized form with a latter mean age of diagnosis, have been analyzed with respect to genetic models currently favored in the dental literature. These include autosomal recessive and X‐linked dominant (partial penetrance) inheritance. Since there is variation in severity, extent, age of onset, altered sex ratio of affected individuals, and a low population prevalence, it is not surprising that genetic mechanisms heretofore have not been revealed.
Differential Influence of Dietary Soy Intake on the Risk of Breast Cancer Recurrence Related to HER2 Status

The effects of soy products and isoflavone on breast cancer recurrence were compared according to receptor status including epidermal growth factor receptor-2 (HER2) with 339 Korean women. Dietary intake of soy foods was assessed using a validated food frequency questionnaire with 103 food items. Twenty-five patients experienced breast cancer recurrence, 17 patients were HER2 negative, and 8 patients were HER2 positive. Legume intake (mostly from black soybeans) was inversely associated with the risk of breast cancer recurrence in HER2 negative cancer patients (HR: 0.27, 95% CI: 0.13–0.57, P for trend < 0.01), whereas legume intake was positively associated in HER2 positive cancer patients (P for trend = 0.02). In HER2 negative cancer patients, isoflavone was inversely associated with breast cancer recurrence (HR: 0.23, 95% CI: 0.06–0.89; P for trend = 0.01). Total soy intake was not associated with an increased risk of cancer recurrence. In conclusion, overall soy food intake might not affect the risk of cancer recurrence, but high intake of soy isoflavones increased the risk of cancer recurrence in HER2-positive breast cancer patients. However, further research is needed to confirm these results due to the small number of cancer recurrence events.
Pentostatin treatment for hairy cell leukemia patients who failed initial therapy with recombinant alpha-interferon: a report of CALGB study 8515.

Eighty-five hairy cell leukemia (HCL) patients who had failed initial therapy with recombinant alpha interferon were enrolled for pentostatin therapy. All had HCL confirmed by central pathology review and were eligible for evaluation. The median age was 55 years (range 31-83 years). Fifteen patients were between 31- and 40-years-old. There were 72 males (85%) and 13 females (15%). Fifty-four patients (64%) had prior splenectomy. All had been previously treated with interferon; nine had achieved a complete response (CR), 36 had a partial response (PR), 35 had stable disease (SD), and five patients had progressive disease. Patients with a CALGB performance status (PS) of 0-2 (78 patients) received 4 mg/m2 i.v. on days 1 and 15, repeated every 4 weeks. Patients with a performance status of 3 or 4 (seven patients) were started at 2 mg/m2 i.v. in the absence of grade 3 toxicity, the dose was escalated. Complete responses were seen in 36 patients (42.4%) and 35 patients had partial responses (41.2%) for an overall response rate of 83.6%. Median time to best response was 6.5 months. Eight patients had stable disease, and one patient had progressive disease. Three patients died early during the treatment phase and two were not evaluable due to treatment violations. Of seven patients with a CALGB performance status of 3 or 4, there were no CRs and only two PRs. Of 31 evaluable PS 0-2 patients who had previously achieved only stable disease on interferon, 13 had a CR on pentostatin and 12 had a PR. Based on PS 0-2 patients, the median follow-up is 44 months and 36 month remission duration and survival rates and 95% confidence intervals are 84% (CI 68-93%) and 91% (CI 81-96%). The 36 month survival rate was 29% (CI 10-58%) for PS 3-4 patients. Drug dosage was modified in 39 (51%) of 76 evaluable patients. Leukopenia and/or infection were the most frequent toxicities leading to a dose modification. Pentostatin is an effective agent and induces an excellent response in relapsed HCL patients previously treated with alpha-interferon (alpha-IFN).
Activation of Peripheral &mgr;-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1–4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain

Background:Opioids have long been regarded as the most effective drugs for the treatment of severe acute and chronic pain. Unfortunately, their therapeutic efficacy and clinical utility have been limited because of central and peripheral side effects. Methods:To determine the therapeutic value of peripheral &mgr;-opioid receptors as a target for neuropathic pain treatment, the authors examined the effects of dermorphin [D-Arg2, Lys4] (1–4) amide (DALDA), a hydrophilic, peripherally acting &mgr;-opioid receptor agonist, in male and female rats with spinal nerve ligation–induced neuropathic pain. The authors also utilized behavioral, pharmacologic, electrophysiologic, and molecular biologic tools to characterize DALDA’s possible mechanisms of action in male rats. Results:DALDA, administered subcutaneously, had 70 times greater efficacy for inhibiting thermal (n = 8 to 11/group) than mechanical hypersensitivity (n = 6 to 8/group) in male rats. The pain inhibitory effects of DALDA on mechanical and heat hypersensitivity were abolished in animals pretreated with systemic methylnaltrexone (n = 7 to 9/group), a peripheral &mgr;-opioid receptor antagonist. In the spinal wide-dynamic range neurons, systemic DALDA inhibited C-fiber–mediated, but not A-fiber–mediated, response in neuropathic male rats (n = 13). In primary sensory neurons, DALDA inhibited the capsaicin-induced [Ca2+] increase more than the &bgr;-alanine–induced [Ca2+] increase (n = 300); capsaicin and &bgr;-alanine activate subpopulations of neurons involved in the signaling of heat and mechanical pain, respectively. DALDA-treated rats (n = 5 to 8/group) did not exhibit motor deficits and locomotor impairment suggesting that it does not induce central side effects. Conclusions:These findings suggest that DALDA may represent a potential alternative to current opioid therapy for the treatment of neuropathic pain and is likely to be associated with minimal adverse effects.
OWNERSHIP STRUCTURE AND INTERNATIONALIZATION: AGENCY PROBLEMS AND DELISTING IN BRAZIL

o nome da revista, a edição, o ano e as páginas nas quais o artigo foi publicado originalmente, mas sem sugerir que a RAM endosse a reutilização do artigo. Esse termo de licenciamento deve ser explicitado para os casos de reutilização ou distribuição para terceiros. Não é permitido o uso para fins comerciais. KLEVERSON DÁLITON SILVA MOREIRA Universidade Federal de Uberlândia (UFU), Uberlândia – MG, Brazil.
Association study of human leucocyte antigen‐A gene with idiopathic male infertility in Han population of China

Human leucocyte antigen (HLA) is a complex gene family that contains several highly polymorphic genes. Some studies have reported HLA‐A gene to have a strong role in idiopathic male infertility in Japanese and Yugoslavia populations. Prompted by these findings, we investigated the distributions of HLA‐A gene to ascertain their associations with idiopathic male infertility in Chinese population. Polymerase chain reaction–sequence‐based typing (PCR‐SBT) method was used for DNA typing at HLA‐A locus in 109 patients with idiopathic male infertility and 152 healthy controls in Han male population of Shaanxi Province, situated in north‐western China. In total, we detected 23 HLA‐A alleles in all infertile patients, 22 HLA‐A alleles in control subjects. However, no significant differences of these allelic frequencies were found between the patients and the control subjects, suggesting that the HLA‐A gene was unlikely a major risk factor of idiopathic male infertility in this sample population. As different populations have different HLA polymorphisms, investigation into the relationship of other HLA genes and idiopathic male infertility in our population is needed in the future.
Stem cell biology and cell transplantation therapy in the retina

Abstract Embryonic stem (ES) cells, which are derived from the inner cell mass of mammalian blastocyst stage embryos, have the ability to differentiate into any cell type in the body and to grow indefinitely while maintaining pluripotency. During development, cells undergo progressive and irreversible differentiation into specialized adult cell types. Remarkably, in spite of this restriction in potential, adult somatic cells can be reprogrammed and returned to the naive state of pluripotency found in the early embryo simply by forcing expression of a defined set of transcription factors. These induced pluripotent stem (iPS) cells are molecularly and functionally equivalent to ES cells and provide powerful in vitro models for development, disease, and drug screening, as well as material for cell replacement therapy. Since functional impairment results from cell loss in most central nervous system (CNS) diseases, recovery of lost cells In addition to donor cell or tissue preparation, manipulation of the host conditions is essential for successful transplantation. Diseased host tissue may exhibit pathological conditions that differ from normal physiological conditions. For instance, inflammation affects the survival, synapse formation, and neural activity of transplanted cells, and except in cases of autotransplantation, immune rejection occurs following cell transplantation. The optimal time windows for photoreceptor transplantation should be determined for every type of retinal degeneration. A better understanding of the pathological host conditions, including immune responses, will be essential for regeneration of retinal function. Optimization of pharmacological drugs and transplantation materials are therefore crucial for successful transplantation.
Gene and protein expression of protease‐activated receptor 2 in structural and inflammatory cells in the nasal mucosa in seasonal allergic rhinitis

Background Protease‐activated receptor 2 (PAR 2) has been shown to be responsible for trypsin and mast cell tryptase‐induced airway inflammation. Here, the present study aimed to explore the expression of PAR 2 in the nasal mucosa of seasonal allergic rhinitis (SAR).
Molecular Basis of Isoform-specific μ-Conotoxin Block of Cardiac, Skeletal Muscle, and Brain Na+ Channels*

μ-Conotoxins (μ-CTXs) block skeletal muscle Na+ channels with an affinity 1–2 orders of magnitude higher than cardiac and brain Na+ channels. Although a number of conserved pore residues are recognized as critical determinants of μ-CTX block, the molecular basis of isoform-specific toxin sensitivity remains unresolved. Sequence comparison of the domain II (DII) S5-S6 loops of rat skeletal muscle (μ1, Nav1.4), human heart (hh1, Nav1.5), and rat brain (rb1, Nav1.1) Na+ channels reveals substantial divergence in their N-terminal S5-P linkers even though the P-S6 and C-terminal P segments are almost identical. We used Nav1.4 as the backbone and systematically converted these DII S5-P isoform variants to the corresponding residues in Nav1.1 and Nav1.5. The Nav1.4→Nav1.5 variant substitutions V724R, C725S, A728S, D730S, and C731S (Nav1.4 numbering) reduced block of Nav1.4 by 4-, 86-, 12-, 185-, and 55-fold respectively, rendering the skeletal muscle isoform more “cardiac-like. ” Conversely, an Nav1.5→ Nav1.4 chimeric construct in which the Nav1.4 DII S5-P linker replaces the analogous segment in Nav1.5 showed enhanced μ-CTX block. However, these variant determinants are conserved between Nav1.1 and Nav1.4 and thus cannot explain their different sensitivities to μ-CTX. Comparison of their sequences reveals two variants at Nav1.4 positions 729 and 732: Ser and Asn in Nav1.4 compared with Thr and Lys in Nav1.1, respectively. The double mutation S729T/N732K rendered Nav1.4 more “brain-like” (30-fold↓ in block), and the converse mutation T925S/K928N in Nav1.1 reproduced the high affinity blocking phenotype of Nav1.4. We conclude that the DII S5-P linker, although lying outside the conventional ion-conducting pore, plays a prominent role in μ-CTX binding, thus shaping isoform-specific toxin sensitivity.
Comment on “Mycorrhizal association as a primary control of the CO2 fertilization effect”

Terrer et al. (Reports, 1 July 2016, p. 72) used meta-analysis of carbon dioxide (CO2) enrichment experiments as evidence of an interaction between mycorrhizal symbiosis and soil nitrogen availability. We challenge their database and biomass as the response metric and, hence, their recommendation that incorporation of mycorrhizae in models will improve predictions of terrestrial ecosystem responses to increasing atmospheric CO2.
Antibody to FcεRIα Suppresses Immunoglobulin E Binding to High-Affinity Receptor I in Allergic Inflammation

Purpose High-affinity receptor I (FcεRI) on mast cells and basophils plays a key role in the immunoglobulin E (IgE)-mediated type I hypersensitivity mediated by allergen cross-linking of the specific IgE-FcεRI complex. Thus, prevention of IgE binding to FcεRI on these cells is an effective therapy for allergic disease. We have developed a strategy to disrupt IgE binding to FcεRI using an antibody targeting FcεRIα. Materials and Methods Fab fragment antibodies, which lack the Fc domain, with high affinity and specificity for FcεRIα and effective inhibitory activity against IgE-FcεRI binding were screened. IgE-induced histamine, β-hexosaminidase and Ca2+ release in basophils were determined by ELISA. A B6.Cg-Fcer1atm1Knt Tg(FCER1A)1Bhk/J mouse model of passive cutaneous anaphylaxis (PCA) was used to examine the inhibitory effect of NPB311 on allergic skin inflammation. Results NPB311 exhibited high affinity to human FcεRIα (KD=4 nM) and inhibited histamine, β-hexosaminidase and Ca2+ release in a concentration-dependent manner in hFcεRI-expressing cells. In hFcεRIα-expressing mice, dye leakage was higher in the PCA group than in controls, but decreased after NPB311 treatment. NPB311 could form a complex with FcεRIα and inhibit the release of inflammation mediators. Conclusion Our approach for producing anti-FcεRIα Fab fragment antibody NPB311 may enable clinical application to a therapeutic pathway in IgE/FcεRI-mediated diseases.