Miracle-dz/UniFAR-FTUs huggingface dataset:
Running head : GUILT IN BEREAVEMENT 2 Guilt in Bereavement : Its Relationship with Complicated Grief and Depression Guilt

Objective: This study investigated the relationship between guilt and well-being of bereaved persons, and explored potential differences in the associations between guilt-CG (complicated grief) and guilt-depression. Method: In total, 1,358 Chinese bereaved adults were recruited to fill out questionnaires. Participants (N=194) who had been bereaved within 2 years of the first survey, filled out the same questionnaires one year later. Results: Higher guilt was associated with higher degrees of both CG and depression. The level of guilt predicted CG and depression symptoms one year later. Bereavement related guilt has a closer association with CG than depression. Responsibility guilt, indebtedness guilt and degree of guilt feeling are more prominent aspects of guilt in CG than in depression. Conclusions: These findings demonstrate the significant role of guilt (perhaps a core-symptom) in mental health of the bereaved, having implications for identifying persons with grief complications and depression.
Challenges and Recent Progress in the Development of Si Anodes for Lithium‐Ion Battery

Silicon, because of its high specific capacity, is intensively pursued as one of the most promising anode material for next‐generation lithium‐ion batteries. In the past decade, various nanostructures are successfully demonstrated to address major challenges for reversible Si anodes related to pulverization and solid‐electrolyte interphase. However, the electrochemical performance is still limited by challenges that stem from the use of nanomaterials. In this progress report, the focus is on the challenges and recent progress in the development of Si anodes for lithium‐ion battery, including initial Coulombic efficiency, areal capacity, and material cost, which call for more research effort and provide a bright prospect for the widespread applications of silicon anodes in the future lithium‐ion batteries.
The role of internal auditing in promoting accountability in Higher Education Institutions

This paper discusses the link between accountability and internal auditing, particularly analyzing up to what extent the latter contributes for improvements in the former, in Higher Education Institutions (HEIs). To empirically analyze the relationship between internal auditing and accountability, the study relies on results of a survey to the management boards of a sample of HEIs, with the main focus on internal auditing carried out by the offices or departments in those institutions. The paper contributes to understand how management boards perceive internal auditing to foster transparency and accountability in HEIs, allowing to corroborate that auditing, and particularly internal auditing, serves accountability. In effect, it promotes the principles underlying accountability practices. The information provided in the scope of internal audits is acknowledged as contributing to improve management effectiveness and helping in decision-making. HEIs wanting to create an internal auditing office or to enhance the role of an existing one, should develop this office’s activities so that is becomes an instrument to support accountability and good governance of the organization. The sample consisted of Portuguese public HEIs, universities and polytechnics. Despite a certain international convergence regarding this type of public sector organizations, as well as regarding their purposes and governance, certain contextual specificities might limit the generalization of the findings to other jurisdictions.
Aalborg Universitet Dual-polarized Dual-band Mobile 5 G Antenna Array

In this paper, a dual-band dual-polarized phased antenna array for 5G mobile terminals is proposed. The array has a bandwidth of 3.6 GHz and two resonances at 30.5 and 32.8 GHz. The array has a clearance of 2.85 mm and fed with two ports in simulation to excite the notch and dipole parts of the proposed antenna structure. Finally, the proposed antenna element is combined into two arrays with different configurations. It is shown that it is better to use the array of 8 elements than to use two 4-element sub-arrays with orthogonal
Effect of different sowing dates on yield and economics of wheat cultivars under North situations of Madhya Pradesh

A field experiment was conducted during Rabi season of 2015-16 at Research Farm, School of Agriculture ITM University Gwalior (MP). The treatments consisted of 2 dates of sowing i.e.; D1 (15th November) and D2 (10th December); and 5 varieties i.e.; V1 to V5 (HD 4730, PBW-343, Raj 4037, HD 4728 and Lok-1). The experiment was conducted in spilt-plot design with three replications. The experimental results revealed that Maximum grain yield (5027.82 kg ha-1), straw yield (6962.84 kg ha-1), gross monetary returns (110592 Rs. ha-1), net monetary returns (80378 Rs. ha-1) and benefit cost ratio (3.66) were recorded under variety HD 4728 at 15th November sowing date compared to other varieties and dates of sowing.
Reinforcing Application Security through User Behavioural Analysis

Rules and signature-based security concepts have shown their limitations in detecting and preventing sophisticated fraud in online systems due to ever-changing attacker’s behaviors. To address this problem, we present a User Behavior Analytics (UBA) approach that reinforces application security by profiling users’ activities and evaluating incoming user sessions against previously learnt models of “normal” (i.e. usual) behavior. Our SKEPTIC approach is based on an unsupervised learning approach that models the expected users’ behaviors based on past activities. After the initial learning phase, the system uses a novel scoring approach to evaluate new incoming sessions and identify “anomalies” highlighting significant deviations from the previously learnt baseline models. These statistical anomalies can be identified on various types of user session features (e.g., infrequent sequences of actions, unusual connection times or abnormal connection origins) and are combined using a multi-criteria aggregation method, which continually adjusts a global risk score for each evaluated session. The risk score can be fed to an intervention module that can be configured to trigger different responses based on the severity level (e.g. trigger identity proofing or locking the user account). We have evaluated our approach on two different datasets: a synthetic dataset simulating a typical scenario of spear-phishing attack in which the attacker is impersonating a legitimate user to gain access to an enterprise network, and a dataset of application logs from a real-world ecommerce application used in the global travel industry. In both cases, our results show that our SKEPTIC approach can successfully detect suspicious events and can prevent common fraud scenarios that involve user impersonation, account take-over or credential compromise.
Topologies for Battery and Supercapacitor Interconnection in Residential Microgrids with Intermittent Generation

Context:This paper presents a comparative study of the performance of three topologies for interconnecting Lithium ion batteries and supercapacitors in a hybrid energy storage system for use in electric residential microgrids with intermittent generation. The hybrid system’s main purpose is to prolong battery life, using the supercapacitor to handle the dynamic component of current from a pulsed current load. This work builds upon a preliminary simulation-based study, in which two semi-active topologies were compared and evaluated. Here, we add an active topology to the study and describe the operational benefits of each topology. Method: For every topology in this study, a non-isolated half-bridge bidirectional DC converter was used, and a proportional–integral (PI) double-loop linear ACC control algorithm was designed for controlling the converters. In the active topology an additional optimisation-based real-time frequency-decoupling control strategy was employed. Results:A parallel active topology allows better management of stored energy in the SC by supporting variation of SC terminal voltages with a DC converter as interface to the DC bus. Conclusions: Semi-active topologies are easier to design and control, but the operational benefits of supercapacitors require voltage variation at the terminals. This variation is made possible with an active topology.
Title Simultaneous loss of interlayer coherence and long-rangemagnetism in quasi-two-dimensional PdCrO 2

Right © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. Type Journal Article
Improved constraints on the expansion rate of the Universe up to z ∼ 1.1 from the spectroscopic evolution of cosmic chronometers

We present new improved constraints on the Hubble parameter H(z) in the redshift range 0.15 < z < 1.1, obtained from the differential spectroscopic evolution of early-type galaxies as a function of redshift. We extract a large sample of early-type galaxies ( ∼ 11000) from several spectroscopic surveys, spanning almost 8 billion years of cosmic lookback time (0.15 < z < 1.42). We select the most massive, red elliptical galaxies, passively evolving and without signature of ongoing star formation. Those galaxies can be used as standard cosmic chronometers, as firstly proposed by Jimenez & Loeb (2002), whose differential age evolution as a function of cosmic time directly probes H(z). We analyze the 4000 Å break (D4000) as a function of redshift, use stellar population synthesis models to theoretically calibrate the dependence of the differential age evolution on the differential D4000, and estimate the Hubble parameter taking into account both statistical and systematical errors. We provide 8 new measurements of H(z) (see table 4), and determine its change in H(z) to a precision of 5–12% mapping homogeneously the redshift range up to z ∼ 1.1; for the first time, we place a constraint on H(z) at z≠0 with a precision comparable with the one achieved for the Hubble constant (about 5–6% at z ∼ 0.2), and covered a redshift range (0.5 < z < 0.8) which is crucial to distinguish many different quintessence cosmologies. These measurements have been tested to best match a ΛCDM model, clearly providing a statistically robust indication that the Universe is undergoing an accelerated expansion. This method shows the potentiality to open a new avenue in constrain a variety of alternative cosmologies, especially when future surveys (e.g. Euclid) will open the possibility to extend it up to z ∼ 2.
Graphene Nanomaterials-Based Radio-Frequency/Microwave Biosensors for Biomaterials Detection

In this paper, the advances in radio-frequency (RF)/microwave biosensors based on graphene nanomaterials including graphene, graphene oxide (GO), and reduced graphene oxide (rGO) are reviewed. From a few frontier studies, recently developed graphene nanomaterials-based RF/microwave biosensors are examined in-depth and discussed. Finally, the prospects and challenges of the next-generation RF/microwave biosensors for wireless biomedical applications are proposed.
Broad Bactericidal Activity of the Myoviridae Bacteriophage Lysins LysAm24, LysECD7, and LysSi3 against Gram-Negative ESKAPE Pathogens

The extremely rapid spread of multiple-antibiotic resistance among Gram-negative pathogens threatens to move humankind into the so-called “post-antibiotic era” in which the most efficient and safe antibiotics will not work. Bacteriophage lysins represent promising alternatives to antibiotics, as they are capable of digesting bacterial cell wall peptidoglycans to promote their osmotic lysis. However, relatively little is known regarding the spectrum of lysin bactericidal activity against Gram-negative bacteria. In this study, we present the results of in vitro activity assays of three putative and newly cloned Myoviridae bacteriophage endolysins (LysAm24, LysECD7, and LysSi3). The chosen proteins represent lysins with diverse domain organization (single-domain vs. two-domain) and different predicted mechanisms of action (lysozyme vs. peptidase). The enzymes were purified, and their properties were characterized. The enzymes were tested against a panel of Gram-negative clinical bacterial isolates comprising all Gram-negative representatives of the ESKAPE group. Despite exhibiting different structural organizations, all of the assayed lysins were shown to be capable of lysing Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, and Salmonella typhi strains. Less than 50 μg/mL was enough to eradicate growing cells over more than five orders of magnitude. Thus, LysAm24, LysECD7, and LysSi3 represent promising therapeutic agents for drug development.
C-type natriuretic peptide co-ordinates cardiac structure and function

Abstract Aims C-type natriuretic peptide (CNP) is an essential endothelium-derived signalling species that governs vascular homoeostasis; CNP is also expressed in the heart but an intrinsic role for the peptide in cardiac function is not established. Herein, we employ unique transgenic strains with cell-specific deletion of CNP to define a central (patho)physiological capacity of CNP in maintaining heart morphology and contractility. Methods and results Cardiac structure and function were explored in wild type (WT), cardiomyocyte (cmCNP−/−), endothelium (ecCNP−/−), and fibroblast (fbCNP−/−)—specific CNP knockout mice, and global natriuretic peptide receptor (NPR)-B−/−, and NPR-C−/− animals at baseline and in experimental models of myocardial infarction and heart failure (HF). Endothelium-specific deletion of CNP resulted in impaired coronary responsiveness to endothelium-dependent- and flow-mediated-dilatation; changes mirrored in NPR-C−/− mice. Ex vivo, global ischaemia resulted in larger infarcts and diminished functional recovery in cmCNP−/− and NPR-C−/−, but not ecCNP−/−, vs. WT. The cardiac phenotype of cmCNP−/−, fbCNP−/−, and NPR-C−/− (but not ecCNP−/− or NPR-B−/−) mice was more severe in pressure overload- and sympathetic hyperactivation-induced HF compared with WT; these adverse effects were rescued by pharmacological CNP administration in WT, but not NPR-C−/−, mice. At a molecular level, CNP/NPR-C signalling is impaired in human HF but attenuates activation of well-validated pro-hypertrophic and pro-fibrotic pathways. Conclusion C-type natriuretic peptide of cardiomyocyte, endothelial and fibroblast origins co-ordinates and preserves cardiac structure, function, and coronary vasoreactivity via activation of NPR-C. Targeting NPR-C may prove an innovative approach to treating HF and ischaemic cardiovascular disorders.
CtACO1 Overexpression Resulted in the Alteration of the Flavonoids Profile of Safflower

Background: Flavonoids with various structures play a vital role in plant acclimatization to varying environments as well as in plant growth, development, and reproduction. Exogenous applications of ethylene and 1-aminocyclopropane carboxylic acid (ACC), could affect the accumulation of flavonoids. Very few attempts have been made to investigate the effect of 1-aminocyclopropane carboxylic acid oxidase (ACO), a unique enzyme that catalyzes ACC to ethylene, on genes and metabolites in the flavonoid biosynthetic pathway. In this study, two ACOs in safflower (CtACOs) were cloned, and then transgenic safflower with overexpressed CtACO1 was generated through the Agrobacterium-mediated floral dipping method. Results: CtACO1 and CtACO2 were both characterized by the 2-oxoglutarate binding domain RxS and the ferrous iron binding site HxDxnH as ACOs from other plants. However, the transcript levels of CtACO1 in flowers at stages I, II, III, and IV were all higher than those of CtACO2. At the cellular level, by using electroporation transformation, CtACO1 was found to be localized at the cytomembrane in onion epidermal cells. CtACO1 overexpression had varying effects on genes involved in the ethylene and flavonoid biosynthetic pathways. The metabolites analysis showed that CtACO1 overexpression lines had a higher accumulation of quercetin and its glycosylated derivatives (quercetin 3-β-d-glucoside and rutin). In contrast, the accumulation of quinochalcones (hydroxysafflor yellow A and carthamin), kaempferol glycosylated derivatives (kaempferol-3-O-β-rutinoside and kaempferol-3-O-β-d-glucoside), apigenin, and luteolin in CtACO1 overexpression lines were decreased. Conclusion: This study confirmed the feasibility of applying the floral dipping method to safflower and showed a novel regulatory effect of CtACO1 in the flavonoid biosynthetic pathway. It provides hypothetical and practical groundwork for further research on regulating the overall metabolic flux of flavonoids in safflower, particularly hydroxysafflor yellow A and other quinochalcones, by using appropriate genetic engineering strategies.
Y cuáles son las tecnologías emergentes para diversificar el consumo de huevo

El desconocimiento frente a las nuevas tendencias y formas de produccion primaria del huevo de gallina para consumo humano, limita el consumo por parte de la poblacion. Sin embargo, es importante dar a conocer a los consumidores, que hoy por hoy, tanto en la produccion primaria como a escala industrial, se han venido aplicando estrategias que mitiguen los riesgos de consumir huevo y por el contrario multipliquen sus propiedades nutricionales y beneficas para la salud humana. Esto se da porque, la industria avicola ha venido creciendo exponencialmente en los ultimos anos, lo que ha hecho que se generen nuevas estrategias de mercado para hacer mas llamativo el producto final y ofrecerle al consumidor diferentes opciones para complementar su dieta con otro tipo de proteina de origen animal. Este documento presenta resultados sobre el mercado del huevo en lo relacionado con nuevos productos, huevo pasteurizado y huevo deshidratado o liofilizado. En lo referente a fortificacion de huevos de gallina se demuestra que el contenido nutricional del huevo es directamente proporcional al tipo de dieta y produccion que reciben las gallinas, entre mas nutrientes beneficos haya, el huevo aportara propiedades funcionales. En lo referente a tendencias en biocompuestos se ha encontrado que entre mas compuestos organicos se investiguen, mejores seran las capacidades del huevo para ser un alimento funcional, conservando sus caracteristicas nutricionales; como con la incorporacion del polen apicola, que hasta el momento ha arrojado datos en los que participa en procesos antibioticos, antimicoticos y antiinflamatorios. En conclusion, el huevo no solo es nutritivo sino funcional para el ser humano y a medida que la tecnologia en el desarrollo de nuevos productos siga avanzando, existiran mas tendencias que diversifiquen aun mas el consumo de huevo de gallina.
Morphometric analyses and gene expression related to germ cells, gonadal ridge epithelial-like cells and granulosa cells during development of the bovine fetal ovary

Cells on the surface of the mesonephros give rise to replicating Gonadal Ridge Epithelial-Like (GREL) cells, the first somatic cells of the gonadal ridge. Later germ cells associate with the GREL cells in the ovigerous cords, and the GREL cells subsequently give rise to the granulosa cells in follicles. To examine these events further, 27 bovine fetal ovaries of different gestational ages were collected and prepared for immunohistochemical localisation of collagen type I and Ki67 to identify regions of the ovary and cell proliferation, respectively. The non-stromal cortical areas (collagen-negative) containing GREL cells and germ cells and later in development, the follicles with oocytes and granulosa cells, were analysed morphometrically. Another set of ovaries (n = 17) were collected and the expression of genes associated with germ cell lineages and GREL/granulosa cells were quantitated by RT-PCR. The total volume of non-stromal areas in the cortex increased significantly and progressively with ovarian development, plateauing at the time the surface epithelium developed. However, the proportion of non-stromal areas in the cortex declined significantly and progressively throughout gestation, largely due to a cessation in growth of the non-stroma cells and the continued growth of stroma. The proliferation index in the non-stromal area was very high initially and then declined substantially at the time follicles formed. Thereafter, it remained low. The numerical density of the non-stromal cells was relatively constant throughout ovarian development. The expression levels of a number of genes across gestation either increased (AMH, FSHR, ESR1, INHBA), declined (CYP19A1, ESR2, ALDH1A1, DSG2, OCT4, LGR5) or showed no particular pattern (CCND2, CTNNB1, DAZL, FOXL2, GATA4, IGFBP3, KRT19, NR5A1, RARRES1, VASA, WNT2B). Many of the genes whose expression changed across gestation, were positively or negatively correlated with each other. The relationships between these genes may reflect their roles in the important events such as the transition of ovigerous cords to follicles, oogonia to oocytes or GREL cells to granulosa cells.
Discovery of Small Molecules That Target Vascular Endothelial Growth Factor Receptor-2 Signalling Pathway Employing Molecular Modelling Studies

Angiogenesis is defined as the formation of new blood vessels and is a key phenomenon manifested in a host of cancers during which tyrosine kinases play a crucial role. Vascular endothelial growth factor receptor-2 (VEGFR-2) is pivotal in cancer angiogenesis, which warrants the urgency of discovering new anti-angiogenic inhibitors that target the signalling pathways. To obtain this objective, a structure-based pharmacophore model was built from the drug target VEGFR-2 (PDB code: 4AG8), complexed with axitinib and was subsequently validated and employed as a 3D query to retrieve the candidate compounds with the key inhibitory features. The model was escalated to molecular docking studies resulting in seven candidate compounds. The molecular docking studies revealed that the seven compounds displayed a higher dock score than the reference-cocrystallised compound. The GROningen MAchine for Chemical Simulations (GROMACS) package guided molecular dynamics (MD) results determined their binding mode and affirmed stable root mean square deviation. Furthermore, these compounds have preserved their key interactions with the residues Glu885, Glu917, Cys919 and Asp1046. The obtained findings deem that the seven compounds could act as novel anti-angiogenic inhibitors and may further assist as the prototype in designing and developing new inhibitors.