Miracle-dz/UniFAR-FTUs huggingface dataset:
Fibrinolytic activity of human uterine fluid

Normal biochemical composition of uterine fluid is essential for survival and successful implantation of the blastocyst. Fibrinolytic enzymes are involved in the implantation process. The variation of the fibrinolytic activity of uterine fluid with the phase of the normal menstrual cycle was investigated with the aid of radial enzyme diffusion on fibrin plates. The lytic activity increased during the pro‐liferative phase, reached a maximum in midcycle and then fell to its lowest level during the luteal phase. It increased again in the premenstruum.
Role of Cathepsin K, L and S in Blood Vessel Remodeling

The development of cardiovascular diseases is characterized by the loss of structural integrity of blood vessels that requires extensive remodeling of the extra-cellular matrix (Michel et al., 2011; Garcia-Touchard et al., 2005). The entire aorta and some medium-sized arteries have elastic properties and mechanical strength allowing these vessels to withstand a surge of blood ejected from the heart. Such properties of blood vessels are contributed mostly by two major components of the extracellular matrix: elastin and collagen (Barbour et al., 2007; Wagenseil & Mecham, 2009; Sawabe, 2010). Elastin fibers are responsible for the elastic properties and collagen fibers provide mechanical strength to the arterial wall (Arteaga-Solis et al., 2000). These two proteins have a fibrillar structure and in their mature forms are very resistant to proteolysis. Thus elastin has a half-life around 50 years (Wagenseil & Mecham, 2009). However in some pathological conditions, excessive proteolytic activity results in extracellular matrix breakdown that is a key factor of arterial wall damage and the development of potential rupture. Sites of atherosclerotic and aneurysmatic lesions are characterized by increased elastoand collagenolytic activity (Diehm et al., 2007; Shimizu et al., 2006; Barbour et al., 2007; Sukhova et al., 1998). The dominant histological feature of aneurysmatic lesions is a chronic medial and adventitial inflammation resulting in medial degeneration and smooth muscle cell apoptosis. One of the most important contributors to aneurysmatic degeneration is an excessive loss of extracellular matrix. Fragmentation of elastin and collagen fibers is a characteristic feature of aneurysm formation and their loss is the ultimate cause of aneurysmatic rupture as well as rupture of atherosclerotic plaques (Shimizu et al., 2006; Sakalihasan et al., 2005; Diehm et al., 2007). Recently it has been shown that together with some matrix metalloproteinases, cathepsin K, L and S are the primary proteolytic culprits responsible for the breakdown of extracellular matrix proteins in blood vessels (Abdul-Hussien et al., 2010; Rizas et al., 2009; Sukhova & Shi, 2006). Cysteine proteinases cathepsin K, L and S belong to the most potent elastoand/or collagenolytic proteinases with potent abilities to degrade extracellular matrix. These enzymes attracted attention due to their upregulation within the aortic wall under different pathological conditions (Lutgens et al., 2007; Lafarge et al., 2010; Liu et al., 2004). Their expression was revealed in macrophages, smooth muscle cells and endothelial cells in atherosclerotic and aneurismal lesions in humans. These results instigated a series of studies on the involvement of cathepsin K, L and S in the development of cardiovascular diseases based on animal models of atherosclerosis and abdominal aortic aneurysm
Both sides of the story: Addiction is not a pastime activity

The proposed inclusion of Internet gaming disorder (IGD) into the upcoming ICD-11 has caused mixed reactions. Having a sound diagnostic framework for defining this new phenomenon has been applauded but concerns have risen regarding overpathologizing a mere pastime activity. The review by Aarseth et al. (2016) provides a fine but one-sided impression on IGD. What has been totally left out in the argumentation is the clinical perspective. Although the concerns depicted must not be ignored, the conclusion provided by the authors is reflecting quite subjective speculations while objectivity would rather be needful.
Inducible glutamate oxaloacetate transaminase as a therapeutic target against ischemic stroke.

SIGNIFICANCE Glutamate serves multi-faceted (patho)physiological functions in the central nervous system as the most abundant excitatory neurotransmitter and under pathological conditions as a potent neurotoxin. Regarding the latter, elevated extracellular glutamate is known to play a central role in ischemic stroke brain injury. RECENT ADVANCES Glutamate oxaloacetate transaminase (GOT) has emerged as a new therapeutic target in protecting against ischemic stroke injury. Oxygen-sensitive induction of GOT expression and activity during ischemic stroke lowers glutamate levels at the stroke site while sustaining adenosine triphosphate levels in brain. The energy demands of the brain are among the highest of all organs underscoring the need to quickly mobilize alternative carbon skeletons for metabolism in the absence of glucose during ischemic stroke. Recent work builds on the important observation of Hans Krebs that GOT-mediated metabolism of glutamate generates tri-carboxylic acid (TCA) cycle intermediates in brain tissue. Taken together, outcomes suggest GOT may enable the transformative switch of otherwise excitotoxic glutamate into life-sustaining TCA cycle intermediates during ischemic stroke. CRITICAL ISSUES Neuroprotective strategies that focus solely on blocking mechanisms of glutamate-mediated excitotoxicity have historically failed in clinical trials. That GOT can enable glutamate to assume the role of a survival factor represents a paradigm shift necessary to develop the overall significance of glutamate in stroke biology. FUTURE DIRECTIONS Ongoing efforts are focused to develop the therapeutic significance of GOT in stroke-affected brain. Small molecules that target induction of GOT expression and activity in the ischemic penumbra are the focus of ongoing studies.
Technique for Visual Explanation of Hidden Web Query Interfaces

In this research work we have proposed two techniques. The primary one is a new technique to characterize concept of query and semantic relative among them. The subsequent proposes is a narrative technique of query extraction based on visual explanation of interfaces, it extract query from obtainable query interface. Work is to propose a technique which integrate query interface of the similar subject in one common query interface. This technique is initial point to a new web service which facilitates Information Retrieval from hidden Web. Our technique for Visual Explanation of Hidden Web Query Interfaces (VEHWQI). We will calculate performance of our technique on conference dataset, average datasets and we will have proof that our technique achieves good precision.
Mammalian cell transcriptome in response to meningitis-causing pathogens

Bacterial meningitis continues to be a major cause of mortality and morbidity, despite improved antimicrobial therapy. A key factor that contributes to this situation is the incomplete understanding of its pathogenesis. High-throughput methods (e.g., DNA microarray technology) can provide a holistic picture of the transcriptional events that underlie the host response to bacterial infections, including that during bacterial meningitis. Since 2001, several studies have been reported on the cellular host’s responses to infections with Neisseria meningitidis and Streptococcus pneumoniae (the leading causes of bacterial meningitis) using DNA microarrays and have described numerous differentially expressed genes. The present review summarizes the main recent findings with gene expression analyses in the field of bacterial meningitis. Experiments that defined a common host response, as well as pathogen-specific host responses, will be discussed. This review will also outline the contributions of global gene analyses to our understanding of the pathophysiology of bacterial meningitis.
Children teach a care-receiving robot to promote their learning

In contrast to conventional teaching agents (including robots) that were designed to play the role of human teachers or caregivers, we propose the opposite scenario in which robots receive instruction or care from children. We hypothesize that by using this care-receiving robot, we may construct a new educational framework whose goal is to promote children's spontaneous learning by teaching through their teaching the robot. In this paper, we describe the introduction of a care-receiving robot into a classroom at an English language school for Japanese children (3--6 years of age) and then conduct an experiment to evaluate if the care-receiving robot can promote their learning using English verbs. The results suggest that the idea of a care-receiving robot is feasible and that the robot can help children learn new English verbs efficiently. In addition, we report on investigations into several forms of teaching performed by children, which were revealed through observations of the children, parent interviews, and other useful knowledge. These can be used to improve the design of care-receiving robots for educational purposes.
Theoretical Analysis on the Relationship between Corporate Public Welfare and Financial Capacity

Enterprise charity is to show the enterprise is not only responsible to the shareholders' interests but also pay more attention to ecological environment, charity and more of the social public welfare of stakeholders, which has become the inevitable trend of enterprise development and the effective ways to enhance the competitiveness of enterprises. As now our corporate social welfare consciousness have improved, and they realized the investment of public welfare improved performance of enterprises. However, with the development of social economy, the improvement of people's living standard, whether the enterprise can play a part in the public welfare has decide the enterprises’ live or death.
Antihypertensive and renal‐protective effects of losartan in streptozotocin diabetic rats

Objective To assess the renal benefits of a specific angiotensin II receptor antagonist, losartan, in diabetic rats with renal impairment. Design and methods Uninephrectomized streptozotocin diabetic spontaneously hypertensive rats (SHR) were randomly assigned to receive vehicle, or to receive losartan or captopril, or both, intraperitoneally via osmotic minipumps for 8 weeks. Results Blood pressure and urinary protein excretion in the diabetic SHR increased progressively during the experimental period. Both captopril treatment and losartan treatment completely blocked the development of hypertension in diabetic SHR. Simultaneous administration of captopril and losartan did not enhance the antihypertensive effects of losartan treatment or captopril treatment. Furthermore, losartan treatment, captopril treatment and losartan + captopril treatment all significantly decreased urinary protein excretion, urinary albumin excretion and serum creatinine to the same extent. These effects were sustained for the entire experimental period and were not associated with any significant changes in body weight, urine volume, urine sugar and urinary electrolytes excretion. These results were confirmed by morphological analysis of kidneys in each group of rats. Losartan treatment, captopril treatment and losartan + captopril treatment all significantly and effectively protected against an increase in the percentage of focal glomerular sclerosis. Losartan treatment and captopril treatment both significantly attenuated the increase in heart weight: body weight ratio. The heart weight: body weight ratio in the losartan-treated group was significantly lower than in the captopril-treated group. Conclusions These results indicate that hypertension could accelerate diabetic renal impairment and that losartan has antihypertensive and renoprotective effects in this rat model. They also suggest that the antihypertensive and renoprotective effects of captopril treatment in this rat model are caused mainly by inhibition of angiotensin II production rather than stimulation of the kallikrein-kinin system or of vasodilator prostaglandins. The difference in potency between losartan treatment and captopril treatment to attenuate the increase in heart weight: body weight ratio might partly explain the existence in the heart of angiotensin-forming pathways, which are not dependent on angiotensin converting enzyme.
Turnaround or Contract Merger: A conceptual model to protect sick and government companies

The prolific competition and unanticipated customer loyalty gave the ideological thought to craft combat strategies among firms, now it became a warriors’ battle. To achieve this, global firms are designing tactics to become a gladiator by choosing merger & acquisition as a synergistic choice. M&A is an opportunity for target firm shareholders in a high premium, on the other hand escalating monopoly by an acquirer in the respective market. These inorganic options will increase the capitalism in mixed economy countries that result in the loss of government control on public sector enterprises and sick industries. Availing this gap, the present conceptual study is aimed to introduce a new weapon for emerging market nations to protect state control and keep public belief. Exclusively, we try to accommodate and suggest a new financial arrangement or scheme against the existing model, i.e. Leveraged buyout (LBO). Finally, this array is supported by the Indian sick industries as case examples which were disappearing now. It also ensures that the economic sustainability and progress of nation would be achieved by the proposed ‘Contract Merger’ model.
Hirschsprung's disease and Ondine's curse: further evidence for a distinct syndrome

Although Hirschsprung's disease is a relatively common congenital malformation, with an estimated incidence of about 1:5000, Primary Central Hypoventilation Syndrome (Ondine's curse) is exceedingly rare, with about 50 reported cases. We describe a patient with total colonic aganglionosis occurring together with failure of automatic control of respiration, specific facial dysmorphology and characteristic CT scan changes to substantiate further the syndromic nature of this association.
Formation of a protein corona on silver nanoparticles mediates cellular toxicity via scavenger receptors.

Addition of a protein corona (PC) or protein adsorption layer on the surface of nanomaterials following their introduction into physiological environments may modify their activity, bio-distribution, cellular uptake, clearance, and toxicity. We hypothesize that silver nanoparticles (AgNPs) will associate with proteins common to human serum and cell culture media forming a PC that will impact cell activation and cytotoxicity. Furthermore, the role of scavenger receptor BI (SR-BI) in mediating this toxicity was evaluated. Citrate-suspended 20 nm AgNPs were incubated with human serum albumin (HSA), bovine serum albumin (BSA), high-density lipoprotein (HDL), or water (control) to form a PC. AgNPs associated with each protein (HSA, BSA, and HDL) forming PCs as assessed by electron microscopy, hyperspectral analysis, ζ-potential, and hydrodynamic size. Addition of the PC decreased uptake of AgNPs by rat lung epithelial and rat aortic endothelial cells. Hyperspectral analysis demonstrated a loss of the AgNP PC following internalization. Cells demonstrated concentration-dependent cytotoxicity following exposure to AgNPs with or without PCs (0, 6.25, 12.5, 25 or 50 μg/ml). All PC-coated AgNPs were found to activate cells by inducing IL-6 mRNA expression. A small molecule SR-BI inhibitor was utilized to determine the role of SR-BI in the observed effects. Pretreatment with the SR-BI inhibitor decreased internalization of AgNPs with or without PCs, and reduced both cytotoxicity and IL-6 mRNA expression. This study characterizes the formation of a PC on AgNPs and demonstrates its influence on cytotoxicity and cell activation through a cell surface receptor.
Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade (*)

Mitogen-activated protein kinase (MAPK) and MAPK kinase (MAPKK) are activated during Xenopus oocyte maturation concomitant with the activation of maturation promoting factor (MPF). We reported previously that an anti-MAPKK neutralizing antibody inhibited progesterone- or Mos- induced initiation of oocyte maturation. Here, we show that injection of CL100 (also called MAPK phosphatase-1) into immature oocytes inhibited progesterone-induced oocyte maturation as well as MAPK activation and that injection of mRNA encoding a constitutively active MAPKK induced activation of histone H1 kinase and germinal vesicle breakdown in the absence of progesterone. Injection of recombinant STE11 protein (a yeast MAPKK kinase) also induced initiation of oocyte maturation. These data support the idea that the MAPKK/MAPK cascade plays an important role in oocyte maturation. Interestingly, injection of the active MAPKK mRNA or the STE11 protein resulted in induction and accumulation of Mos protein. Furthermore, in the presence of cycloheximide, the STE11-induced activation of MPF as well as the induction and accumulation of Mos was blocked, and the activation of MAPK was greatly reduced. The increase in Mos protein and the activation of MAPK by injecting cyclin A protein into immature oocytes were both blocked also by cycloheximide treatment. These results are consistent with an idea that there may exist a positive feedback loop consisting of Mos, the MAPKK/MAPK cascade, and MPF, which may be important for the initiation of oocyte maturation induced by progesterone.
Planar and Cylindrical CPW Fed Dual Frequency Folded Slot Antennas

Planar and cylindrical dual frequency folded slot antennas utilizing a self-matching technique have been presented. The self-matching technique greatly improved the performance of the antennas while not further complicating the antenna design. The antennas exhibit very good return loss and radiation characteristics. The antennas demonstrated a gain between 3.2 and 5.3 dB. The antennas are ideally suited for communication and radar systems, which require robust antennas that can operate at multiple frequencies
Fingerprint Matching Based on Inter-minutiae Constraint Network

This paper presents a new fingerprint matching algorithm based on inter-minutiae relational network. This latter is represented by constraint graph (binary CSP graph) which uses, in addition to distances between minutiae, ridge counts and the relative ridge count angles according to the both minutiae pair orientations. Therefore, the resulting minutiae features are invariant to the geometric transformation and the matching process does not require an implicit alignment of the two fingerprint images. The main advantage of our approach is that it can be used for partial fingerprints. Finally, we report the results of testing our method on the public fingerprint databases DB1 and DB2 FVC2002
DEVELOPMENT STRATEGIES OF A NATIONAL COMPANY IN TRANSNATIONAL OLIGOPOLISTIC MARKET: The case of Cooperative Pascual

The objective of this paper is to analyze the success reached due to the implementation of the strategies used by Cooperativa Pascual. An analytic approach is used to understand it’s most important problematic. After the labor shortcut in 1982 and posterior worker´s strike that lasted more than 3 years that lead to the delivery of the company assets to the workers, the firm changed its name from “Pascual S.A. ” to “Cooperativa Pascual”. Despite all this struggles, the company could perform as one of the best firms at national level in the beverage industry. Cooperativa Pascual is an example of strategy application in companies, because it competes with some of the biggest transnational like Coca-Cola, Pepsi, and others.
Factors Affecting Employeesâ?? Performance: A Case of Kabul-Based Telecom Firms

This study synthesizes the body of literature on employees’ performance and develops a conceptual framework that depicts plausible impacts of employees’ participation, job involvement, and employees’ relations on employees’ performance. Herzberg two-factor theory is considered for this study as a theoretical anchor. To test the model, the study uses a sample of 200 employees working in Kabul-based telecom firms. The study finds a positive and significant impact of employees’ participation, job involvement, and employer-employees relations on employees’ performance. This research will help managers in the telecom sector to understand ways to enhance employees’ performance by having an insight of the factors affecting it
Bladder cancer: State‐of‐the‐art care

The challenge in bladder cancer is to control superficial disease and prevent its recurrence or progression. Patients with invasive disease need to be identified earlier, when disease may be less advanced and more amenable to cure. An important area for further investigation is the biology of the various forms of bladder cancer and the various pathways of development they may follow.
Sovereign Debt Restructurings: Delays in Renegotiations and Risk Averse Creditors

Foreign creditors’ business cycles influence both the process and the outcome of sovereign debt restructurings. We compile two datasets on creditor committees and chairs and on creditor business and financial cycles at the restructurings. We find that when creditors experience high GDP growth, restructurings are delayed and settled with smaller haircuts. To rationalize these stylized facts, we develop a theoretical model of sovereign debt with multiround renegotiations between a risk averse sovereign debtor and a risk averse creditor. The quantitative analysis of the model shows that high creditor income results in both longer delays in renegotiations and smaller haircuts. Our theoretical predictions are supported by data.
Multigene expression in vivo: Supremacy of large versus small terminators for T7 RNA polymerase

Designing and building multigene constructs is commonplace in synthetic biology. Yet functional successes at first attempts are rare because the genetic parts are not fully modular. In order to improve the modularity of transcription, we previously showed that transcription termination in vitro by bacteriophage T7 RNA polymerase could be made more efficient by substituting the standard, single, TΦ large (class I) terminator with adjacent copies of the vesicular stomatitis virus (VSV) small (class II) terminator. However, in vitro termination at the downstream VSV terminator was less efficient than at the upstream VSV terminator, and multigene overexpression in vivo was complicated by unexpectedly inefficient VSV termination within Escherichia coli cells. Here, we address hypotheses raised in that study by showing that VSV or preproparathyroid hormone (PTH) small terminators spaced further apart can work independently (i.e., more efficiently) in vitro, and that VSV and PTH terminations are severely inhibited in vivo. Surprisingly, the difference between class II terminator function in vivo versus in vitro is not due to differences in plasmid supercoiling, as supercoiling had a minimal effect on termination in vitro. We therefore turned to TΦ terminators for “BioBrick” synthesis of a pentameric gene construct suitable for overexpression in vivo. This indeed enabled coordinated overexpression and copurification of five His‐tagged proteins using the first construct attempted, indicating that this strategy is more modular than other strategies. An application of this multigene overexpression and protein copurification method is demonstrated by supplying five of the six E. coli translation factors required for reconstitution of translation from a single cell line via copurification, greatly simplifying the reconstitution. Biotechnol. Bioeng. 2012; 109:1043–1050. © 2011 Wiley Periodicals, Inc.