Miracle-dz/UniFAR-FTUs huggingface dataset:
Targetable molecular pathways in classical Hodgkin's lymphoma

Introduction: Most patients with classical Hodgkin's lymphoma (cHL) are cured by stage-adapted multimodal regimens. However, some will suffer from refractory disease or experience a relapse. Furthermore, late toxicity due to aggressive chemotherapy and/or radiotherapy has become an increasing problem in long-term survivors. Special situations, such as cHL in a post-transplant setting and patients not able to tolerate standard therapy, are also challenging. Targeting molecular pathways could be a way to find solutions for these varied aspects. Areas covered: Research undertaken by leading experts in the field of cHL is summarized. The literature search encompasses all data available via PubMed or published (pre-)clinical trials until August 2010. We discuss the crucial molecular pathways in cHL, novel agents that may be utilized to interact with these pathways, and insights into the results of current clinical trials utilizing these novel therapeutics. Expert opinion: The most important oncogenic pathways in cHL are loss of B-cell identity by the neoplastic cells, activation of the NF-κB pathway, and constitutive activation of the JAK2-STAT-pathway. Both monoclonal antibodies and small-molecule inhibitors are potentially useful agents to target these pathways.
Intellectual capital resource transformation and inertia in inter-firm partnership

Although scholars and practitioners in strategic management recognized the importance of resources acquired from alliance partners, prior studies have been paid little attention to examining how firms individually contribute their resources and how the inertia hinders cooperative performance. By linking the strategy practice and intellectual capital perspective, this study aims at understanding how resource transformation and inertia have their effects on cooperative performance. Conducting by in-depth case study, we investigated six inter-firm cases of a Taiwanese company and its partners at the dyad-level analysis. We adopted IC approaches to understand more completely about the intellectual capital management in practice. By revealing the process of resource transformation and examining the inertia, this study provides the valuable references for practitioners on strategizing the inter-firm collaborative strategy.
Effects of swimming and walking on exercise recovery and subsequent swim performance.

Abstract Six female collegiate swimmers were used to evaluate the hypothesis that the recovery procedure after exercise will not only affect subsequent performance, but will also affect the recovery process after the subsequent performance. Each swimmer exercised for two minutes at 90% [Vdot]O2 max on a swimming ergometer, recovered for 15 minutes by walking on land or swimming, then swam 200 yds. for time. Oxygen uptake was measured for 15 minutes after the 200 yd. swim. Venous blood, obtained after the ergometry swim, and before and after the 200 yd. swim, was analyzed for lactate. Two hundred yard swim times were not significantly affected by either the walking or swimming recovery procedures. Blood lactate after the ergometry swim averaged 96.7 ± 18 mg/100 ml. The swimming recovery reduced the lactate levels by 53.3% compared to a 38.5% reduction during the walking recovery. Significant differences in blood lactate were also noted after the 200 yd. swim, with the trials in which swimming recovery prot.
Impact Of Social Media Usage On Organizations

Social media is a growing phenomenon and have the biggest impact on organizations’ continual communication with customers and the public. It also plays increasingly important role as a marketing platform. Even though social media has been recognized as the most powerful medium in business practice, there is lack of understanding in terms of how social media benefits the organization. Therefore, this study using mixed method techniques such as website analysis, interviews and survey aims to investigate the various factors that influence the social media usage and its subsequent impact on organizations. Based on the qualitative findings and literature review, the TOE framework was identified as the appropriate model for this study.
Robust Preprocessing for Kalman Filtering of Glint Noise

The non-Gaussian character of glint noise is demonstrated by exploratory data analysis. This non-Gaussian behavior is characterized by outliers in the form of glint spikes. Since glint noise is processed by an angle-tracking Kalman filter, and since the latter is quite nonrobust, strategies are proposed to minimize the effect of these glint spikes. One of the strategies, which involves robust preprocessing of the data, is pursued in detail. Finally, some results of a planar missile simulation are presented that clearly demonstrate the merits of the robust preprocessing strategy.
Device-Free Electromagnetic Passive Localization Using Link Line Information in Wireless Sensor Networks

The electromagnetic passive localization without the need of carrying any device, named device-free passive localization (DFPL) technique, is an emerging technology for determining an uncooperative target’s position. The DFPL technique detects the shadowed links in a monitored area and realizes localization with the received signal strength (RSS) measurements of these links. However, most current RSS-based DFPL schemes belong to the model-based DFPL method, since the localization accuracy depends on the shadowing model. Moreover, model-based DFPL methods require high memory and computing resources for accurate tracking performance, and thus may not be suitable for resourceconstrained applications. To overcome these problems, in this paper we propose a lightweight DFPL method which makes use of recent link lines detected by wireless sensor networks to estimate the target’s location. This method can be independent of the shadowing model and can also reduce the algorithm’s storage and computational resource requirements. The effectiveness and robustness of the proposed scheme are demonstrated by experimental results where the proposed algorithm yields substantial improvement for localization performance and complexity.
Determinants Of Reporting Nonrecurring Charges Subsequent To Business Combinations

This study examines nonrecurring earnings charges following business combinations and the characteristics that influence their reporting. The study uses a sample of 216 business combinations in which the acquiring firm reported either goodwill or other asset impairments or restructuring charges with respect to a target firm. The results show that changes in the level of CEO cash compensation and institutional ownership are factors that are positively associated with nonrecurring earnings charges in the post-acquisition period. The findings suggest that the transparency of nonrecurring transactions subsequent to a business combination is evident with the expense treatment of acquisition-related costs.
A Study of Factors Affecting Consumer Evaluations and Memory of Product Placements in Movies

Abstract An important issue for a firm wishing to invest in a product placement is deciding how its product or brand is going to be presented within the movie. Accordingly, the objective of this research study is to examine the impact of objective and subjective characteristics of product placements on consumer evaluations and memory. A sample of 103 movie goers viewed and reacted to 18 product placements taken from 11 different movies. After a one-week delay, they were contacted and asked to recall the products and brands they had seen. Based on the results, it appears that the effectiveness of product placement as a communication strategy must be gauged against the specific objectives of decision makers.
Tecnologia da Informação Verde: Um Estudo sobre sua Adoção nas Organizações Green Information Technology: A Study of its Adoption in Organizations

Due to the need to better understand the relationship between sustainability strategies and Information Technology (IT), this research aims to analyze the adoption of Green IT initiatives in organizations by specifically examining the adoption motives, implemented practices, perceived benefits and difficulties. To this end, we conducted three case studies with companies from different economic sectors, Orlikowski’s research (1992) was fundamental in contributing to the theoretical framework. We found that most Green IT initiatives can be categorized within the intersections formed by the three sustainability dimensions – environmental, social and economic – and a fourth dimension called legal. Furthermore, we found the implementation of these practices started by identifying financial and operational benefits associated with their adoption. The results reveal that environmental benefits emerge as a positive consequence of changes caused by legal and economic aspects. We hope this study can help executives in planning and implementation of Green IT in their organizations, as well as for researchers interested in researching this topic.
Increasing the effectiveness of financial education in the workplace

is a nonprofit research organization, supported by an association of more than 120 banks, insurance companies, industrial corporations and public institutions. Established in 1968 and closely affiliated with the University of Frankfurt, it provides a strong link between the financial community and academia. The CFS Working Paper Series presents the result of scientific research on selected topics in the field of money, banking and finance. The authors were either participants in the Center´s Research Fellow Program or members of one of the Center´s Research Projects. If you would like to know more about the
An Efficient TSC 1-out-of-3 Code Checker

A design method for a combinational totally self-checking (TSC) 1-out-of-3 code checker is presented. This method is not only simpler and more efficient than others, but is also successful in the case where more than one 1-out-of-3 code exists in a TSC system. >
Nitric Oxide and Reactive Oxygen Species in the Pathogenesis of Preeclampsia

Preeclampsia (PE) is characterized by disturbed extravillous trophoblast migration toward uterine spiral arteries leading to increased uteroplacental vascular resistance and by vascular dysfunction resulting in reduced systemic vasodilatory properties. Its pathogenesis is mediated by an altered bioavailability of nitric oxide (NO) and tissue damage caused by increased levels of reactive oxygen species (ROS). Furthermore, superoxide (O2−) rapidly inactivates NO and forms peroxynitrite (ONOO−). It is known that ONOO− accumulates in the placental tissues and injures the placental function in PE. In addition, ROS could stimulate platelet adhesion and aggregation leading to intravascular coagulopathy. ROS-induced coagulopathy causes placental infarction and impairs the uteroplacental blood flow in PE. The disorders could lead to the reduction of oxygen and nutrients required for normal fetal development resulting in fetal growth restriction. On the other hand, several antioxidants scavenge ROS and protect tissues against oxidative damage. Placental antioxidants including catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) protect the vasculature from ROS and maintain the vascular function. However, placental ischemia in PE decreases the antioxidant activity resulting in further elevated oxidative stress, which leads to the appearance of the pathological conditions of PE including hypertension and proteinuria. Oxidative stress is defined as an imbalance between ROS and antioxidant activity. This review provides new insights about roles of oxidative stress in the pathophysiology of PE.
Pharmacological profile of a tachykinin antagonist, spantide, as examined on rat spinal motoneurones

1 The pharmacological profile of a tachykinin antagonist, [d‐Arg1, d‐Trp7,9, Leu11] substance P (spantide), was studied on motoneurones of the isolated spinal cord of the newborn rat. For this purpose, potentials were recorded from a lumbar ventral root extracellularly and drugs were bath‐applied in the presence of tetrodotoxin (TTX). 2 Neurokinin A (NKA), a NK2‐receptor selective agonist, induced concentration‐dependent depolarizations, which were antagonized by spantide. Analyses of concentration‐response curves suggested a competitive type antagonism with a pA2 of 6.5. 3 Depolarizations induced by acetyl‐Arg6‐septide, a NK1‐receptor selective agonist, were also antagonized by spantide with a pA2 of 6.5. 4 Spantide (0.5–16 μm) had no depolarizing action on the ventral root in the presence of TTX. 5 Spantide antagonized the depolarizing action of substance P (SP) when SP was applied at low concentrations (0.1–0.3 μm) or by short duration pulses in artificial cerebrospinal fluid containing TTX, but much higher concentrations of spantide (4–10 μm) were needed to exert an antagonistic action against SP than against acetyl‐Arg6‐septide or NKA. 6 Thyrotrophin‐releasing hormone, l‐glutamate, GABA, and noradrenaline, also induced depolarizations of the ventral root in the presence of TTX but the responses to these agonists were not depressed by spantide (16 μm). 7 These results suggest that there is a subtype of tachykinin receptors on neonatal rat spinal motoneurones to which NKA, acetyl‐Arg6‐septide and spantide bind competitively with high affinity. The present results also suggest the existence on rat motoneurones of another class or other classes of tachykinin receptors that are less sensitive to the antagonistic action of spantide.
Estrogen replacement and exercise capacity in postmenopausal women: A randomized placebo-controlled study

Objective. We tested the hypothesis that estrogen replacement (2 mg estradiol/day, orally for 90 days) would improve cardiopulmonary and functional capacities in postmenopausal women. Study design. Twenty-three postmenopausal and sedentary women were divided into estrogen replacement (n = 13, 57 ± 2 years) and placebo control (n = 10, 58 ± 2 years) groups. They performed a cardiopulmonary exercise test before and after the intervention. Results. Baseline measurements were similar between groups. Blood pressure and heart rate at rest and during exercise were unchanged by estrogen treatment, and estrogen did not alter pulmonary measurements at rest and during exercise. Oxygen consumption at anaerobic threshold, respiratory compensation point and peak exercise were lower after estrogen replacement, despite the unchanged workload and exercise time to exhaustion. In the placebo control group, no change in peak oxygen consumption, workload and time to exhaustion was found. Conclusions. Estrogen does not change cardiopulmonary responses to submaximal and maximal exercise in postmenopausal women. In addition, estrogen fails to improve exercise capacity in postmenopausal women.
Improving the skills of health professionals in engaging patients in diabetes‐related problem solving

Introduction: Despite instruction, many patients do not employ diabetes‐related self‐management skills recommended by health professionals. One problem suggested by research is that many health professionals do not often use teaching and counseling skills widely considered to be effective. Among these are specific skills that help health professionals conduct adherence‐related assessments, brainstorm workable solutions to obstacles, collaborate during long‐term follow‐up, and provide effective direct instruction. Methods: “Effective Patient Teaching and Problem Solving” was developed and taught in a block of 24 hours over 3 days to groups of health professionals. Course content emphasized 13 operationally defined skills in four major categories: (A) assessment, (B) brainstorming, (C) collaboration, and (D) direct instruction skills. To evaluate participants' (n = 33) use of the various skills, a standardized patient teaching exercise was videotaped at both the beginning and end of the course. Results: Total mean scores increased significantly (t = 7.7, p < .001) from 1.8 to 2.5 on a scale that ranged from 1 to 5. Skills improved in all four major categories (p <.003). The length of teaching sessions did not change, lasting 13.2 minutes before the course and 13.6 minutes after the intervention. Discussion: Health professionals play a crucial role in patient education but rarely receive training in effective teaching and counseling techniques. The “Effective Patient Teaching and Problem Solving” course improved several kinds of important skills. As standards of diabetes care for improved glycemic control become more widespread, and as health providers attempt not just to teach but also to help patients overcome considerable obstacles to consistent diabetes self‐management, a premium will be placed on the ability of health professionals to counsel efficiently and effectively.
A combination of anti-CD 3 and anti-CD 7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease

This study evaluated the anti-graft versus host disease (GVHD) potential of a combination of immunotoxins (IT), consisting of a murine CD3 (SPV-T3a) and CD7 (WT1) monoclonal antibody both conjugated to deglycosylated ricin A. In vitro efficacy data demonstrated that these IT act synergistically, resulting in an approximately 99% elimination of activated T cells at 10 28 mol/L (about 1.8 mg/mL). Because most natural killer (NK) cells are CD7 1, NK activity was inhibited as well. Apart from the killing mediated by ricin A, binding of SPV-T3a by itself impaired in vitro cytotoxic T-cell cytotoxicity. Flow cytometric analysis revealed that this was due to both modulation of the CD3/T-cell receptor complex and activationinduced cell death. These results warranted evaluation of the IT combination in patients with refractory acute GVHD in an ongoing pilot study. So far, 4 patients have been treated with 3 to 4 infusions of 2 or 4 mg/m 2 IT combination, administered intravenously at 48-hour intervals. The T 1/2 was 6.7 hours, and peak serum levels ranged from 258 to 3210 ng/mL. Drug-associated side effects were restricted to limited edema, fever, and a modest rise of creatine kinase levels. One patient developed low-titer antibodies against ricin A. Infusions were associated with an immediate drop of circulating T cells, followed by a more gradual but continuing elimination of T/NK cells. One patient mounted an extensive CD8 T-cell responsedirectlyafter treatment, notaccompanied with aggravating GVHD. Two patients showed nearly complete remission of GVHD, despite unresponsiveness to the extensive pretreatment. These findings justify further investigation of the IT combination for treatment of diseases mediated by T cells. (Blood. 2000;95:3693-3701)
Evaluation of Core Competition of Logistic Firm

Based on the analysis of the factors interrelated to the core competition of logistic firm, a poly index estimating logistic company's core competition is designed. A fuzzy evaluation method to estimate core competition is developed and applied in some firms. Helping logistic firm to determine its object market and enhance its core competition is the target of this paper. 
Referral for autopsies: analysis of 651 consecutive deaths in one general practice

Autopsies represent a key instrument in educating doctors and may aid quality assurance for primary and secondary care. This study shows that only a few patients have an autopsy, of which the majority are carried out at the request of the coroner for medicolegal reasons. Better education and communication between general practitioners, hospital clinicians, pathologists, and coroners may increase the rate of autopsies.
Price presentation effects on green purchase intentions

Purpose – This paper aims to examine the effect of price promotion presentation formats on consumers’ green purchase intentions across various levels of greenness. Despite the increasing awareness of environmental issues and green products among consumers, there is a gap between their green attitude and purchase intentions. Previous studies show that consumers’ degree of greenness varies and that price plays an important role in their green consumption decision-making. Design/methodology/approach – Two between-subject experiments with 236 participants were used to examine our hypotheses and conceptual model. Findings – The results show that different formats of price promotion presentations influence consumers’ purchase perceptions differently. Consumers with a high degree of greenness are attracted to promotions emphasizing gain, while those with a low degree of greenness prefer promotions underlining reduced loss. In addition, medium-greenness consumers show similar reactions to both formats. Our studie.
Endothelin‐1‐induced myocardial ischaemia and oedema in the rat: involvement of the ETA receptor, platelet‐activating factor and thromboxane A2

1 The objectives of the present experiments were to assess the role of ETA receptors in mediating endothelin‐1 (ET‐1)‐induced myocardial ischaemia and oedema and to study the involvement of platelet‐activating factor (PAF) and thromboxane A2 (TxA2) in these actions of ET‐1 in rats. 2 Intravenous bolus injection of ET‐1 (0.1–2 nmol kg−1) into anaesthetized rats induced ST segment elevation of the electrocardiogram in a dose‐dependent manner without causing arrhythmias. ST segment elevation developed within 20–90 s and persisted for at least 10–20 min following administration of ET‐1. 3 Pretreatment of the animals with the selective endothelin ETA receptor antagonist, FR 139317 (2.5 mg kg−1, i.v.) inhibited by 86% the ST segment elevation elicited by ET‐1 (1 nmol kg−1). Pretreatment with intravenous administration of BM 13505 (1 mg kg−1), a TxA2 receptor antagonist, OKY‐046 (10 mg kg−1), a thromboxane synthase inhibitor or the specific PAF receptor antagonist, WEB 2086 (1 mg kg−1) or BN 52021 (10 mg kg−1) markedly suppressed ST segment elevation in response to ET‐1. Infusion of indomethacin (3 mg kg−1 bolus plus 2 mg kg−1 h−1) did not significantly affect ET‐1‐induced ST segment elevation. 4 Bolus injection of ET‐1 (1 nmol kg−1, i.v.) to conscious rats resulted in a prolonged pressor effect preceded by a transient depressor response. Corresponding to changes in blood pressure, a small transient tachycardia was followed by a sustained bradycardia. ET‐1 enhanced albumin leakage by 87 and 120% in the left ventricle and right atrium, respectively, as measured by the extravasation of Evans blue dye. 5 The selective ETA receptor antagonist, FR 139317 (2.5 mg kg−1) significantly blunted the pressor action of ET‐1 and the accompanying bradycardia without affecting the depressor response. Furthermore, FR 139317 almost completely abolished the permeability effect of ET‐1 in both vascular beds studied. 6 Pretreatment of the animals with BM 13505 (1 mg kg−1), OKY‐046 (10 mg kg−1), WEB 2086 (1 mg kg−1) or BN 52021 (10 mg kg−1) significantly reduced ET‐1 (1 nmol kg−1)‐induced albumin extravasation both in the left ventricle and right atrium. The PAF receptor antagonists, WEB 2086 and BN 52021 were equally potent inhibitors in the left ventricle, whereas BN 52021 appeared to be a more potent inhibitor than WEB 2086 in the right atrium. Pretreatment with indomethacin (3 mg kg−1 plus 2 mg kg−1 h−1) did not modify the permeability response to ET‐1. None of these compounds affected significantly ET‐1‐induced changes in mean arterial blood pressure and heart rate. 7 These results indicate that intravenous administration of ET‐1 provokes ST segment elevation and myocardial oedema and suggest that these events are mediated, in part, through release of secondary mediators, such as PAF and TxA2 via the activation of ETA receptors.