Miracle-dz/UniFAR-FTUs huggingface dataset:
Relevance of the Balance between Glia‐Derived Nexin and Thrombin following Lesion in the Nervous System

The original objective of our project was the purification of a macromolecule, released by glial cells, which is capable of promoting neurite outgrowth in mouse neuroblastoma cells. ' Upon characterization of the purified protein we unexpectedly realized that this neurite-promoting factor was a very potent serine protease inhibitor.2 The cDNA sequence coding for this protein confirmed that it was a member of the serpin ~uperfamily. ~ The first amino acids coded by this cDNA exactly matched the 28 amino acids known at the time to be the aminoterminal of protease nexin-1 (PNl). ' The glia-derived protein was thus the first member of the nexin family defined by a complete amino acid sequence. Unable to support the claim that it was identical to PN-1, we decided to call it glia-derived nexin (GDN). S Subsequently, McGrogan ct al. obtained the amino acid sequence of PN-1, also through cDNA cloning, and demonstrated that the two proteins are i den t id6 GDN/PN-l inhibits serine proteases such as thrombin, urokinase, plasminogen activator and trypsin upon formation of SDS-resistant complexes. Dennis Cunningham describes these biochemical propehes in his presentation (in this volume). We shall recapitulate our present knowledge about the in vivo occurrence of GDN and discuss some of the steps triggered during thrombininduced neurite retraction.
Физическое воспитание как средство гармонического развития личности

Барсукова Т. А. Физическое воспитание как средство гармонического развития личности / Т. А. Барсукова, А. А. Бирюков // Правові та інституційні механізми забезпечення розвитку України в умовах європейської інтеграції : матеріали Міжнародної науково-практичної конференції (м. Одеса, 18 травня 2018 р.) У 2-х т. Т. 2 / відп. ред. Г. О. Ульянова. – Одеса : Видавничий дім «Гельветика», 2018. – С. 745-747.
First-principles study of the nano-scaling effect on the electrochemical behavior in LiNi0.5Mn1.5O4

Nano-scaling of electrode materials is often used in battery applications to enhance performance, particularly relating to rate capability. However, for the high-voltage spinel LiNi0.5Mn1. 5O4 conflicting results have been reported on the benefits of nano-scaling. In this study, we present first-principles calculations to investigate the effect of nano-scaling on LiNi0.5Mn1. 5O4, specifically focusing on the roles and coupling between surface stability, cation ordering and phase behavior. We calculate and compare the surface energy for the low index facets (100), (110), and (111), and find that the most stable facet is dependent on the cation ordering at the surface layer. In this context, we predict a spontaneous surface reconstruction in the cation-ordered structure which leads to a deviation from the perfect surface cation ordering and results in an enhanced accessibility to solid solution behavior as a function of Li content. Our results imply that nano-scaling will be more beneficial for the cation-ordered structure, as compared to the disordered structure where the solid solution region is already intrinsically accessible for a broad range of Li concentrations.
Antibiotics Modulate Vaccine-Induced Humoral Immune Response

ABSTRACT The effects of antibiotics on the antigen-specific humoral immune response are not known. Macrolides, tetracyclines, and beta-lactams are commonly prescribed antibiotics. The first two are known to have immunomodulatory activities. The effects of clarithromycin, doxycycline, and ampicillin on the primary and secondary antibody responses to tetanus toxoid, a pneumococcal polysaccharide vaccine, a hepatitis B virus surface antigen (HBsAg) vaccine, and live attenuatedSalmonella typhi (Ty21a) were investigated using a mouse model. For the mice receiving the tetanus toxoid, the immunoglobulin M (IgM) level of the clarithromycin group at day 7 was significantly lower than the corresponding antibody level of the normal saline (NS) group. For the mice receiving the pneumococcal polysaccharide vaccine, the total antibody and IgM levels of the clarithromycin group and the IgM level of the doxycycline group at day 7 were significantly lower than the corresponding antibody levels of the ampicillin and NS groups. For the mice receiving the HBsAg vaccine, the IgM level of the doxycycline group at day 7 was significantly lower than the corresponding antibody levels of the clarithromycin and NS groups, while the IgM level of the clarithromycin group at day 28 was significantly lower than the corresponding antibody levels of the doxycycline, ampicillin, and NS groups. For the mice receiving all three vaccines, there were no statistically significant differences between any of the antibody levels of the ampicillin group and the corresponding antibody levels of the NS group. For the mice receiving Ty21a, the total antibody levels of the ampicillin group at days 7 and 21 were significantly higher than the corresponding antibody levels of the NS group. Moreover, the IgM levels of the clarithromycin, doxycycline, and ampicillin groups at days 7 and 21 were significantly higher than the corresponding antibody levels of the NS group. Furthermore, the total antibody level of the ampicillin group at day 21 was significantly higher than the corresponding antibody level of the doxycycline group. For all four vaccines, there were no statistically significant differences among the serum levels of interleukin-10 and gamma interferon for the mice treated with the various antibiotics. We conclude that clarithromycin and doxycycline, but not ampicillin, suppress the antibody responses of mice to T-cell-dependent and T-cell-independent antigens, whereas all three antibiotics enhance the antibody response to live attenuated mucosal bacterial vaccines.
Islet Cell Autoantigen of 69 kDa Is an Arfaptin-related Protein Associated with the Golgi Complex of Insulinoma INS-1 Cells*

Islet cell autoantigen of 69 kDa (ICA69) is a cytosolic protein of still unknown function. Involvement of ICA69 in neurosecretion has been suggested by the impairment of acetylcholine release at neuromuscular junctions upon mutation of its homologue gene ric-19 in C. elegans. In this study, we have further investigated the localization of ICA69 in neurons and insulinoma INS-1 cells. ICA69 was enriched in the perinuclear region, whereas it did not co-localize with markers of synaptic vesicles/synaptic-like microvesicles. Confocal microscopy and subcellular fractionation in INS-1 cells showed co-localization of ICA69 with markers of the Golgi complex and, to a minor extent, with immature insulin-containing secretory granules. The association of ICA69 with these organelles was confirmed by immunoelectron microscopy. Virtually no ICA69 immunogold labeling was observed on secretory granules near the plasma membrane, suggesting that ICA69 dissociates from secretory granule membranes during their maturation. In silico sequence and structural analyses revealed that the N-terminal region of ICA69 is similar to the region of arfaptins that interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. ICA69 is therefore a novel arfaptin-related protein that is likely to play a role in membrane trafficking at the Golgi complex and immature secretory granules in neurosecretory cells.
dsorption of heavy metals onto activated carbons derived from olyacrylonitrile fiber uhammad

The aim of this research is to produce activated carbons derived from polyacrylonitrile (PAN) fiber and to examine their feasibility of removing heavy metals from aqueous solution. Thermogravimetric analysis was used to identify the suitable conditions for preparing oxidized fiber and coke as activated carbon precursors. Steam and CO2 were used to activate the precursors. Activated carbons were characterized by their pore texture, elemental compositions and surface functionalities. Batch adsorption and desorption studies were carried out to determine the metal-binding ability of activated carbons. Two commercial activated carbon fibers (ACFs), i.e., A-20 and W10-W, were employed to compare the removal performance of PAN derived activated carbons. Influence of oxidation treatment of PAN fiber prior to steam
Power system frequency control with dead band by using kinetic energy of variable speed wind power generators

This paper proposes a new method to suppress frequency variations of power system with large amount of wind power installed by using the kinetic energy of the wind power generators. In recent years, environmental problems have been becoming serious and wind power generation with less environmental impacts has attracted much attention and introduced. Since wind power generation is an unstable power source in which its output fluctuates due to wind speed variations, wind power generator output must be smoothed when supplied to the power system. This paper proposes a control method to suppress the power system frequency variation by increasing or decreasing the wind power generator output using its kinetic energy only when the frequency variation exceeds specified threshold value. It is shown in the paper that the new method makes it possible to decrease the loss of wind generator output as well as suppress the frequency variation than the conventional methods.
Globalisation and labour relations in Australian airlines industry : A case study of pilot experience

Globalisation and labour relations in Australian airlines industry: A case study of pilot experience Peter Schulte and Ying Zhu The University of Melbourne The 1989 pilots’ dispute fundamentally altered the nature of pilot labour relations in Australia. The once powerful pilot union was convincingly defeated by airline management with the assistance of the Government. Since the dispute ended in 1989, globalisation has become an increasingly important factors infl uencing the reform agenda for both state and airlines companies. This paper aims to research the impact that globalisation has had on the pilot labour relations in Australia through the investigation of the initiatives and response of key players such as airline management, pilot unions, and pilots themselves. The results show that the infl uence of management over the pilot labour relations process has increased substantially. The conditions of employment and their ability to collectivise through trade unions have been systematically suppressed by a series of ‘reform agenda’ with the neoliberal ideological orientation. Important challenges for the future of pilot labour relations in Australia are also considered.
Analysis of a conical corrugated horn operating in the K-band with low cross-polarization and high aperture efficiency, and observing its radiation patterns

In this paper, a simulation based design and analysis of a conical corrugated horn is performed. The design concentrated on reduction of cross-polarization. Optimizing the parameters for operation in a frequency band rather than a single frequency required multiple simulations and noting the effects of parameter variations. The optimized design along with the simulation results are presented here. The design can be further improved by making the corrugation length variable which could not be done here due to software limitations. Also a tapered feed can be attached to the horn to enhance its performance. The work can be extended by building a practical working model of the horn and observing its performance.
Experimental and TCAD Study of Breakdown Voltage Temperature Behavior in $n^{+}/p$  SiPMs

In this paper, the breakdown voltage in avalanche photodiodes operating in Geiger mode is investigated. In particular, the breakdown voltage dependence on the structural characteristics of n+/p avalanche diodes, such as implant dose and epitaxial layer thickness and doping concentration, as well as the temperature behavior are analyzed. The study includes both experimental data and numerical simulations. The first are acquired in a controlled temperature environment on samples featuring different electrical structures. Simulations are performed both at the technological process as well as at the electrical level using a commercial TCAD software. Agreement between experiments and numerical analysis is found to be quite good and first hints on how to improve the breakdown voltage uniformity and temperature dependence are given. Moreover, with the aid of TCAD simulations, the potential sources of device breakdown voltage fluctuations related to both device process variability and the properties of the starting silicon wafers are investigated.
Changes in the use of postacute care during the initial Medicare payment reforms.

OBJECTIVE To examine changes in postacute care (PAC) use during the initial Medicare payment reforms enacted by the Balanced Budget Act of 1997. DATA SOURCES We used claims data from the 5 percent Medicare beneficiary sample in 1996, 1998, and 2000. Linked data from the Denominator file, Provider of Service file, and Area Resource File provided additional patient, hospital, and market-area characteristics. STUDY DESIGN Six disease groups with high PAC use were selected for analysis. We used multinomial logit regression to examine how PAC use differed by year of service, controlling for patient, hospital, and market-area characteristics. PRINCIPAL FINDINGS There were major changes in PAC use, and a portion of services shifted to settings where reimbursement remained cost-based. During the first reform, the home health agency interim payment system, home health use decreased consistently across disease groups. This decrease was accompanied by increased use in skilled nursing facilities (SNFs). Following the implementation of the prospective payment system for SNFs, the use of inpatient rehabilitation facilities increased. CONCLUSIONS The shift in usage among settings occurred in two stages that corresponded to the timing of payment reforms for home health agencies and SNFs. Evidence strongly suggests the substitutability between PAC settings. Financial incentives, in addition to clinical needs and individual preferences, play a major role in PAC use.
Word Graph-Based Multi-sentence Compression: Re-ranking Candidates Using Frequent Words

Multi-Sentence Compression is a task whose goal is to produce a short single sentence summary from a group of similar sentences. This paper presents a new re-ranking method based on frequent words extraction along with our modifications on a word graph-based MSC approach to reduce incorrect output. Compression candidates are re-ranked according to the number of frequent words they contain to select the most relevant output. Results of automatic evaluations performed in English and Vietnamese datasets show that the proposed method remarkably improves the generated compressions informativity.
Familial hemophagocytic lymphohistiocytosis and viral infections

A retrospective study was performed in 32 children with hemophagocytic lymphohistiocytosis, 16 of whom had affected siblings. Altogether 22 of these children, of whom the majority (13/22) were familial cases, had clinical or laboratory signs of infection. Laboratory analysis demonstrated Epstein‐Barr virus in five children, cytomegalovirus in three and human parvovirus in two. Two siblings with onset of familial hemophagocytic lymphohistiocytosis within one month of each other, both of whom demonstrated serological indications of a recent human parvoviral infection at onset, are described. It is concluded that a viral infection cannot serve as the sole criterion for distinguishing a virus‐associated hemophagocytic syndrome as an entity separate from familial hemophagocytic lymphohistiocytosis. Instead, it is suggested that viral infections may elicit a bout of the familial hemophagocytic lymphohistiocytosis disorder in genetically predisposed individuals.
Suivi des programmes d'étude de la biodiversité végétale dans la Zona Ecologia de Sao Tomé : Projet ECOFAC - Composante Sao Tomé et Principe

Afin de tenir compte du relief tres accidente de l'ile, divers amenagements du protocole d'inventaire d'Ecofac ont ete proposes: - utilisation de sentiers existant pour la realisation des inventaires, - layon isohypse, - transect avec changement de direction, - introduction de la limite dbh > 50 cm (au lieu de dbh > 70 cm) dans les forets d' altitude, dans la bande des 50 m de large - introduction de la limite dbh > 5 cm (au lieu de dbh > 10 cm) dans les forets d' altitude, dans la bande des 5 m de large. Le bilan des inventaires realises au 14 janvier 1995 est le suivant: - longueur des layons inventories: 4589 m (soit 2,3 ha dans la bande des 5 m pour les dbh > 10 cm et 23 ha pour la bande des 50 m de large pour les dbh > 70 cm). - superficie des quadrats inventories: 2000 m2 (0,2 ha). Au cours de la mission, 205 numeros d'herbier ont ete recoltes en 3 exemplaires; une collection complete a ete deposee dans les locaux du projet Ecofac a Bom Sucesso. Un inventaire des 791 especes de Spermatophytes (1 gymnosperme et 790 angiospermes) recensees a Sao Tome et Principe, est propose sur tableur Excel en indiquant pour chaque espece le statut phytogeographique, le nom vernaculaire et une reference d'herbier ou d'etiquettage in vivo realise dans le cadre du projet Ecofac/Sao Tome. Ce document est presente egalement par ordre alphabetique des noms vernaculaires afin de faciliter la conversion en noms latins. Une attention particuliere a ete apportee a l'analyse des 125 taxons endemiques en presentant des listes d'especes endemiques separees pour Sao Tome (100 taxons endemiques) et pour Principe (38). Ainsi pour Sao Tome, les inventaires Ecofac ont permis de localiser a ce jour 39 taxons endemiques sur 100. Une classification de l'abondance et surtout de la rarete des especes endemiques a ete realisee afin de mettre en evidence les especes menacees d' extinction. La meme demarche a ete effectuee pour les Pteridophytes (lycopodes, selaginelles et fougeres). Une liste des 158 especes recensees dans les 2 iles est proposee avec une nomenclature actualisee et mise en evidence des 9 especes de fougeres endemiques. Un programme d'etude de la biodiversite pour l'annee 1995 a ete propose; il prevoit l'amenagement de l'herbarium, un programme des inventaires a realiser ainsi que des protocoles pour l' etude phenologique et pour l'etude des plantes medicinales.
An adaptive algorithm for detecting and preventing attacks in telecommunication networks

This article proposed method for monitoring threats preparing attacks on the telecommunications network and to prevent opportunities for their implementation. The method is based on monitoring the implementation of states in the functioning of the network components, vulnerability assessment and determination of the facts of preparation intruder attacks (monitoring risks of attacks) by finding the warning function on a given interval of time.
A central role for S-nitrosothiols in plant disease resistance

Animal S-nitrosoglutathione reductase (GSNOR) governs the extent of cellular S-nitrosylation, a key redox-based posttranslational modification. Mutations in AtGSNOR1, an Arabidopsis thaliana GSNOR, modulate the extent of cellular S-nitrosothiol (SNO) formation in this model plant species. Loss of AtGSNOR1 function increased SNO levels, disabling plant defense responses conferred by distinct resistance (R) gene subclasses. Furthermore, in the absence of AtGSNOR1, both basal and nonhost disease resistance are also compromised. Conversely, increased AtGSNOR1 activity reduced SNO formation, enhancing protection against ordinarily virulent microbial pathogens. Here we demonstrate that AtGSNOR1 positively regulates the signaling network controlled by the plant immune system activator, salicylic acid. This contrasts with the function of this enzyme in mice during endotoxic shock, where GSNOR antagonizes inflammatory responses. Our data imply SNO formation and turnover regulate multiple modes of plant disease resistance.
Study of switching flux permanent magnet machines using interpolation based reluctance network model

The aim of this paper is to present an electromagnetic model dedicated to the predesign of Radial Switching Flux Permanent Magnet (RSFPM) machines. This model is based on two independent reluctance networks (RN) for the stator and rotor modeling coupled using interpolation functions in the sliding surface located in the air-gap. The validation of the developed model is followed by a parametric study of a 12 slots / 10 poles RSFPM generator in order to maximize the average electromagnetic torque and to reduce its ripples. This operation is established by finding the suitable rotor tooth opening and skewing angle. The used modeling approach takes into consideration the 3D skewing effect. The main results are compared to those obtained by finite elements (FE) simulation with commercial software.
Induction of Melanocyte-specific Microphthalmia-associated Transcription Factor by Wnt-3a*

Microphthalmia-associated transcription factor (Mitf) plays a critical role in the development of neural crest-derived melanocytes. Here, we show that exogenously added Wnt-3a protein, an intercellular signaling molecule, up-regulates the expression of endogenous melanocyte-specific Mitf (Mitf-M) mRNA in cultured melanocytes. The melanocyte-specific promoter of the humanMITF gene (MITF-M promoter) contains a functional LEF-1-binding site, which is bound in vitro by LEF-1 and confers the preferential expression on a reporter gene in melanocytes and melanoma cells, as judged by the transient transfection assays. Moreover, the LEF-1-binding site is required for the transactivation of a reporter gene by LEF-1, β-catenin, or their combination. Exogenously added Wnt-3a protein also transactivates theMITF-M promoter via the LEF-1-binding site; this activation was abolished when a dominant-negative form of LEF-1 was coexpressed. These results suggest that Wnt-3a signaling recruits β-catenin and LEF-1 to the LEF-1-binding site of the MITF-M promoter. Therefore, the present study identifies Mitf-M/MITF-M as a direct target of Wnt signaling.
Turn-Taking Analysis in EFL Research Seminar at Graduate Program of State University of Makassar

The aim of this research is to probe the types of turn-taking strategy and its functions in interaction of EFL students’ research proposal seminars. This research was conducted purposively toward four students of English education study program in the fourth semester in 2018, Graduate Program of State University of Makassar. For collecting data, the researcher employed descriptive qualitative method based on conversational analysis as a part of discourse analysis approach by using video recorder. It was conducted to monitor, analyze, and interpret the spoken language used by presenters, audiences, and examining committee in research proposal seminars. Findings of this research revealed that there are some kinds of turn-taking strategies used in EFL students’ research proposal seminars interaction, i.e. (1) taking the turn in terms of starting up, taking over, and interrupting; (2) holding the turn in terms of filled pause, silent pause, lexical repetition, and new start; and (3) yielding the turn in terms of prompting, appealing, and giving up. This research found new functions of prompting, namely ensuring and suggesting. Moreover, there are new functions of lexical repetition, namely repairing and emphasizing. Keywords: Turn-taking, English as Foreign Language (EFL) students’ research seminars.
Co‐citation Context Analysis and the Structure of Paradigms

Many information scientists are concerned with the operation of document retrieval systems serving scientists in various fields. The scientists served by these systems are often members of what have been called invisible colleges, groups of scientists in frequent communication with one another and involved with highly specialized subject matters. Often such groups are considered to share an intellectual perspective regarding this subject matter, which is sometimes referred to as a paradigm.