Miracle-dz/UniFAR-FTUs huggingface dataset:
Human papillomavirus therapeutic vaccines: targeting viral antigens as immunotherapy for precancerous disease and cancer

Infections with oncogenic HPV types have the potential to lead to the induction of several types of cancer, notably cervical, vulvar, anal, and head and neck cancer. While prophylactic vaccines are currently available and show high efficacy against the establishment of HPV infection, low rates of initiation and lower rates of completion of the vaccination regimen, as well as the lack of an opportunity to be vaccinated prior to infection, has lead to the development of a patient population for whom no immune-based therapy for infection is available. In the current review the authors examine clinical approaches to HPV-targeted immune therapies, the bulk of which target the regulatory proteins E6 and E7 that are constitutively expressed in HPV-associated cancer cells. Early studies demonstrate a correlation between induction of T-cell responses and clearance of HPV-associated precancerous lesions. The clinical data corroborates these findings and highlight the importance of Th1 skewing. Improvements in our understanding of tumor immunology and development of more potent Th1-directed vaccine platforms make it feasible to foresee a HPV therapeutic vaccine in the coming years.
Power-performance modelling of mobile gaming workloads on heterogeneous MPSoCs

Games have emerged as one of the most popular applications on mobile platforms. Recent platforms are now equipped with Heterogeneous Multiprocessor System-on-Chips (HMPSoCs) tightly integrating CPUs and GPUs on the same chip. This configuration enables high-end gaming on the platform but at the cost of high power consumption rapidly draining the underlying limited-capacity battery. The HMPSoCs are capable of independent Dynamic Voltage and Frequency Scaling (DVFS) for CPUs and GPUs for reduction in platform's power consumption. State-of-the-art power manager for mobile games on HMPSoCs oversimplifies the complex CPU-GPU interplay. In this paper, we develop power-performance models predicting the impact of DVFS on mobile gaming workloads. Based on our models, we propose an efficient power management strategy and implement it on an Odroid-XU+E mobile platform. Measurements on the platform show that our power manager provides on average 20% increase in performance per watt when compared to the state-of-the-art.
An Exact Algorithm for the Two-Dimensional Stage-Unrestricted Guillotine Cutting/Packing Decision Problem

We propose a new exact algorithm for the two-dimensional stage-unrestricted guillotine cutting/packing decision problem, which asks if a set of rectangular items can be cut from a single stock rectangle using guillotine cuts only, with fixed item orientation or with 90-degree item rotation. Our algorithm constructs patterns of items by means of horizontal and vertical builds. To speed up the algorithm and reduce its memory requirement, patterns are constructed in the order of nondecreasing waste, the patterns that use the same subset of items are grouped together, and dominated patterns in each group are discarded. Moreover, a heuristic capable of completing a partial pattern is repeatedly used during the algorithm to quickly determine a feasible solution. Furthermore, the algorithm tries to prove infeasibility with a subset of items before considering all items. We test our algorithm on benchmark instances for the two-dimensional guillotine strip-cutting problem, which we solve by varying the strip height and testing with our algorithm whether a feasible solution exists. We show that our approach outperforms all previously proposed algorithms for the problem with fixed item orientation. Computational experiments for the problem with item rotation are also reported.
Free Radicals in Gastroenterology: A Review

Many exogenous and endogenous agents can disturb the delicate balance between oxygen free radical-generating and antioxidant mechanisms, thereby influencing all kinds of metabolic pathways. An increasing number of papers on free radical toxicity in gastroenterology and hepatology is published every year, and it is expected that the extensive research on the matter will yield important therapeutic consequences. Here we discuss the chemistry of oxygen free radical production, the process of lipid peroxidation, free radical-induced tissue injury and the antioxidant defense mechanisms. The role of free radicals in several gastroenterologic and hepatologic diseases is reviewed.
A GRG2-Based System for Training Neural Networks: Design and Computational Experience

Artificial neural networks is a very active area of research in artificial intelligence. They are better than existing methods for many problems in pattern recognition and pattern matching. They are trained through examples rather than being programmed. Training neural networks is a nonlinear minimization problem. The currently popular algorithm for training neural networks is called back-propagation, a form of steepest descent technique. This paper presents a new training system based on GRG2, a widely distributed nonlinear optimization software. Comparisons with back-propagation based upon three benchmark problems suggest not only that the GRG2-based system is much faster, more robust and offers solutions with better quality, but also offers better scalability to larger problems. This paper is thus a clear example of the kinds of contributions that optimization theory can make to artificial intelligence. INFORMS Journal on Computing, ISSN 1091-9856, was published as ORSA Journal on Computing from 1989 t.
Genetic Algorithms and Random Keys for Sequencing and Optimization

In this paper we present a general genetic algorithm to address a wide variety of sequencing and optimization problems including multiple machine scheduling, resource allocation, and the quadratic assignment problem. When addressing such problems, genetic algorithms typically have difficulty maintaining feasibility from parent to offspring. This is overcome with a robust representation technique called random keys . Computational results are shown for multiple machine scheduling, resource allocation, and quadratic assignment problems. INFORMS Journal on Computing , ISSN 1091-9856, was published as ORSA Journal on Computing from 1989 to 1995 under ISSN 0899-1499.
Manual of Dysphagia Assessment in Adults

Foreword by John C. Rosebek, Ph.D. Medical Record Review and Patient Interview. The Clinical Swallowing Examination. Videofluoroscopic Examination. The Laryngoscopic Evaluation of Swallowing or FEES. Reporting the Findings. Final Thoughts. Issues of Dysphagia Management.
Driving Behavior Analysis for Smartphone-based Insurance Telematics

Insurance telematics programs are continuously gaining market shares in the automotive insurance industry. By recording data on drivers' behavior, the information asymmetry between the policyholder and the insurer is reduced, enabling a granular risk differentiation based on the true risk levels of the drivers. However, the growth of the insurance telematics industry is being held up by large logistic costs associated with the process of acquiring data. As a result, several market participants have started looking towards smartphone-based solutions, which have the potential of easing and improving the data collection process for both policyholders and insurers. In this paper, we present a unified framework highlighting the challenges of smartphone-based driver behavior analysis. Since all driver behavior analysis relies on access to accurate navigation data, we first address the intermediate step of smartphone-based automotive navigation. The considered topics include estimation of the smartphone's orientation with respect to the vehicle, classification of the smartphone owner as a passenger or driver, and navigation in GNSS-challenged areas. Once a driver-specific high-performance navigation solution has been obtained, it can be used to extract information on the driver's behavior. We review the most commonly employed driving events, and discuss some of the difficulties inherent in detecting these events.
Wearable Inertial Sensor for Jump Performance Analysis

Wearable devices enable the unobtrusive sensing of a wide range of human activities and the development of innovative applications. While the consumer market is pushing them particularly as activity or heart rate trackers, their adoption in healthcare is still restricted to few cases, primarily due to their limited accuracy and reliability. An interesting field of application is the jump performance assessment. It is frequently used by therapists to estimate neuromuscular imbalances, since it helps to monitor training progress in athletes or injured patients. Measurements are typically captured with accurate but expensive instrumentation (e.g. force plates). In this work, we propose the use of a versatile low-cost wearable device equipped with inertial sensors for the evaluation of jump height, which can be easily employed at home. We consider two categories of jumps, the counter-movement jump (a single vertical jump) and the plyometric jump (the fast repetition of 4 jumps). The proposed approach, after an initialization phase, uses gyroscope data to continuously track the orientation of the device and align it with the vertical plane and the accelerometer data to estimate the jump trajectory. To validate the system, we collected 200 jumps performed with our device and the Myotest and we observed a mean difference of 0.7 cm (max. 1.9 cm) for the counter-movement jumps and 0.6 (max. 2.1 cm) for the plyometric jumps.
Behaviour of platelets and β-thromboglobulin

Platelet count, platelet aggregation responses, and plasma beta-thromboglobulin were assessed before and at intervals during each study dialysis. As expected, modest thrombocytopenia was observed following treatment with all dialysers, but Filtral showed the least effect. Concordantly, modest increases in plasma beta-thromboglobulin were observed with all devices except Filtral (caveat: the device also seems to adsorb beta-thromboglobulin). Interpatient variability was more striking for platelet aggregation responses, and made it difficult to discern patterns; however, aggregation in response to ADP was augmented during haemodialysis with the Filtral device, and blunted when the G120 M was employed. Differences between hollow-fibre and parallel plate devices with the same membrane material suggest that membrane geometry, manufacturing residues, membrane support, or potting materials may also contribute to platelet activation.
Stopping Criteria for Finite Length Genetic Algorithms

Considerable empirical results have been reported on the computational performance of genetic algorithms but little has been studied on their convergence behavior or on stopping criteria. In this paper we derive bounds on the number of iterations required to achieve a level of confidence to guarantee that a genetic algorithm has seen all populations and, hence, an optimal solution.
Scheduling Periodic Tasks

We consider the problem of nonpreemptively scheduling periodic tasks on a minimum number of processors, assuming that the tasks have to be executed strictly periodically. We show that the problem is NP-complete in the strong sense, even in the case of a single processor, but that it is solvable in polynomial time if the periods and execution times are divisible. The latter condition generalizes the situation in which all periods and execution times are powers of 2. We also propose an approximation algorithm, which is based on successively assigning tasks to processors according to some priority rule.
Constraint-Based Tools for Building User Interfaces

A constraint describes a relation that must be maintained. Constraints provide a useful mechanism to aid in the construction of interactive graphical user interfaces. They can be used to maintain consistency between data and a view of the data, to maintain consistency among multiple views, to specify layout, and to specify relations between events and responses for describing animations of interactive systems and event-driven simulations. Object-oriented techniques for constraint representation and satisfaction are presented, and a range of examples that demonstrate the practical use of static and temporal constraints for such purposes is presented. These examples include animations of algorithms and physics simulations, and constructing user-interface elements such as file browsers, views onto statistical data, and an interactive monitor or a simulated operating system.
Comparative study of RF energy harvesting rectifiers and proposal of output voltage universal curves for design guidline

This paper studies rectifier circuits for RF energy harvesting based on Dickson charge pump. The best configuration of rectifiers is found that the body terminals of FETs are connected to their drains. Its performance is particularly superior when the load resistance is relatively higher. We also studied some derivative circuits, where the gate terminals are connected not to the own drains but the drains of the second neighbor FETs. In addition to this, we propose a new design guideline for determining the optimal rectifier parameters based on the output voltage universal curve. It helps us to find the optimum rectifier design parameters depending on the specification of the application targets.
Long-term prognosis and incidence of acute myocardial infarction in patients on chronic hemodialysis

Abstract Mortality from cardiovascular disease is high in chronic dialysis patients. We observed the occurrence of acute myocardial infarction (AMI) in the chronic dialysis population in Okinawa, Japan. A total of 3,741 chronic dialysis patients (2,073 men, 1,668 women) were followed up for 10 years from April 1, 1988, to March 31, 1998. Only definite cases of AMI were registered. Data were compared with AMI registry data obtained from the general population of the same district. The total duration of observation was 15,748.8 patient-years. During the study period, 61 patients (40 men, 21 women) had AMI. The incidence of AMI was 3.9/1,000 patient-years (men, 4.4/1,000 patient-years; women, 3.1/1,000 patient-years). Twenty-four percent of the AMI cases occurred at 12 months after starting dialysis therapy. Mean age at onset of AMI was 60.9 ± 11.4 (SD) years; 58.9 ± 11.4 years in men and 64.7 ± 10.7 years in women. Survival rates after AMI were 50.8% at 1 month, 45.0% at 6 months, 36.5% at 12 months, and 13.0% at 44 months. Patients with diabetes mellitus (DM) had a greater incidence of AMI and a worse prognosis than patients without DM. The long-term prognosis of AMI was poor in chronic dialysis patients.
Evaluating OR/MS Journals via PageRank

Scholars, practitioners, and students in operations research and management science (OR/MS) often hesitate to use traditional approaches to evaluate journal quality because of the inconsistency of these approaches to perceptions and other associated biases. We introduce an alternative approach, which is based on Google's PageRank, to evaluate 31 OR/MS journals. This approach enhances the impact factor method by considering both citation quantity and quality. When we apply our method to OR/MS journals, the results match survey opinions and significantly outperform rankings based on impact factors. In addition, we provide an extensive discussion of other methods that have been used to assess journal quality. Compared to these methods, our method is better able to discern quality differences for journals that are perceived to be of relatively higher quality. Most importantly, we integrate our method into a Web-based journal-ranking system.
Autoantibodies against a 210kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis

It has been reported that the presence of anti‐nuclear antibody against a 210kDa glycoprotein of nuclear pore complex (anti‐gp210) is highly speciﬁc for primary biliary cirrhosis (PBC). The aim of the present study was to investigate the signiﬁcance of anti‐gp210, especially as a prognostic marker. The presence of anti‐gp210 was ascertained in 113 patients with PBC and 162 controls by indirect immunoﬂuorescence assay using HepG2 cells and immunoblotting analysis using nuclear extracts from HeLa cells. Anti‐gp210 was detected in 25 of the 113 (22.1%) patients. None of the 162 controls was positive for anti‐gp210. The appearance and titre of anti‐gp210 in the patients with PBC did not vary from the time of diagnosis and through their clinical course. Anti‐mitochondrial antibodies (AMA), including antibodies against pyruvate dehydrogenase complex, branched chain α‐ketoacid dehydrogenase complex and α‐ketoglutarate dehydrogenase complex, were not detected by enzyme‐linked immunosorbent assay in ﬁve of the 113 (4.4%) patients with PBC. However, anti‐gp210 alone was positive in one of these ﬁve patients. The difference in prognosis was statistically signiﬁcant; patients with PBC positive for anti‐gp210 died from hepatic failure more frequently than those who were negative (P < 0.01), although there were no statistically signiﬁcant differences in the frequency of jaundice and the histological stage at the time of diagnosis between the two groups. We suggest that the presence of anti‐gp210 is one of the independent prognostic markers able to predict, at the time of diagnosis, a poor outcome in patients with PBC.
Factors Affecting the Termination of Physical Therapy Services for Children in School Settings

This study was designed to investigate physical therapists' perspectives on termination of services in school settings. A questionnaire was mailed to a random sample of 975 members of the American Physical Therapy Association, Section on Pediatrics. There were 686 respondents (70.3% response rate) and 325 worked in schools. They were mature (≥41.0 years old), experienced (≥16.3 years in PT, ≥12.8 years in pediatrics, ≥9.7 years in schools) physical therapists. They mainly worked part-time (54.0%) in suburban schools (40.6%). The most important factor in considering termination of physical therapy under actual and ideal circumstances was when the children met their functional goals. The severity of the child's cognitive and physical impairment was also considered important. Influences from administration were not important. The results suggest these experienced, mature physical therapists do not have problems discharging children from physical therapy. School administrators apparently played no role in discharge decisions made by this experienced group of physical therapists.
Two-shot SVBRDF capture for stationary materials

Material appearance acquisition usually makes a trade-off between acquisition effort and richness of reflectance representation. In this paper, we instead aim for both a light-weight acquisition procedure and a rich reflectance representation simultaneously, by restricting ourselves to one, but very important, class of appearance phenomena: texture-like materials. While such materials' reflectance is generally spatially varying, they exhibit self-similarity in the sense that for any point on the texture there exist many others with similar reflectance properties. We show that the texturedness assumption allows reflectance capture using only two images of a planar sample, taken with and without a headlight flash. Our reconstruction pipeline starts with redistributing reflectance observations across the image, followed by a regularized texture statistics transfer and a non-linear optimization to fit a spatially-varying BRDF (SVBRDF) to the resulting data. The final result describes the material as spatially-varying, diffuse and specular, anisotropic reflectance over a detailed normal map. We validate the method by side-by-side and novel-view comparisons to photographs, comparing normal map resolution to sub-micron ground truth scans, as well as simulated results. Our method is robust enough to use handheld, JPEG-compressed photographs taken with a mobile phone camera and built-in flash.
Optimization of Multidisciplinary Staffing Improves Patient Experiences at the Mayo Clinic

Common approaches to emergency department (ED) staffing are to optimize shifts based on historical patient volume or arrival patterns. The former is problematic because historical patient volumes are based on the volumes during existing shifts. Therefore, optimizing shifts based on these volumes can replicate the inefficiencies in these shifts. The latter approach ignores queueing effects. To address the shortcomings of these commonly used approaches, we use classification and regression trees to identify thresholds for patient-to-staff ratios, which split the patient subpopulations into two groups that have different empirical cumulative distribution functions (ecdfs) for patients’ lengths of stay in the ED; one has an extended length and the other has a shorter length. We apply these thresholds and ecdfs to historical patient volumes to calculate an ideal patient volume. After accounting for arrival patterns of ED patients, ideal patient volumes represent the load on the entire ED if patient-to-staff ra.
Glutathione, GlutathioneS-Transferase α and π, and Aldehyde Dehydrogenase Content in Relationship to Drug Resistance in Ovarian Cancer

Abstract Glutathione, glutathione S -transferases α and π, and aldehyde dehydrogenase are associated with resistance to carboplatin and/or cyclophosphamide in cell lines. Therefore, we examined whether the expression of these factors in ovarian cancer tissue specimens is associated with resistance of the patients to combination chemotherapy with cyclophosphamide/carboplatin. Ovarian cancer tissue specimens were taken intraoperatively from 139 patients and frozen in liquid nitrogen, and the contents of glutathione S -transferases α and π, total glutathione, and aldehyde dehydrogenase activity were determined. No association between the levels of glutathione S -transferases α and π or aldehyde dehydrogenase activity in tumor tissue and the survival time was observed in patients with primary ovarian cancer. Significantly higher levels of aldehyde dehydrogenase were observed in FIGO stage I and II compared to FIGO stage III and IV tumors ( P = 0.019, Wilcoxon test, two sided). The median survival time was significantly longer in patients with primary ovarian cancer with a tumor glutathione content of P = 0.047). However, glutathione was not an independent prognostic factor, but was significantly associated with FIGO stage resulting in higher levels in FIGO stage III and IV tumors than in FIGO stage I and II tumors ( P = 0.0094, Wilcoxon test, two sided). In conclusion the glutathione content was associated with progression of ovarian carcinomas but neither glutathione nor glutathione S -transferases α and π or aldehyde dehydrogenase were independent factors of resistance to cyclophosphamide/carboplatin.