Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of multicentric or cranial mediastinal high-grade T-cell lymphoma in dogs with a first-line CCNU-L(-chlorambucil)-CHOP protocol

This retrospective study determined disease free survival (DFS) and progression free survival (PFS) in chemo-naive dogs with multicentric or cranial mediastinal high-grade T-cell lymphoma, treated with a first-line CCNU-L(-chlorambucil)-CHOP protocol. Of thirteen dogs with multicentric lymphoma, 92.3% achieved a complete remission (CR), and the median DFS and PFS was 317 and 256 days, respectively. Three dogs had cranial mediastinal lymphoma, and achieved a CR with a median DFS and PFS of 978 and 1007 days, respectively. The oneand two-year DFS/PFS probability estimate for dogs with multicentric lymphoma was 0.50/0.46 and 0.42/0.38, respectively, for dogs with cranial mediastinal lymphoma 0.67/0.67. Neutropenia and thrombocytopenia were reported in 52.9% and 50% of the dogs, respectively, while 56.3% experienced grade 1-4 nephrotoxicity, hypothesized to be lomustine-induced. It was concluded that, compared to historical data, the currently described first-line CCNU-L(-chlorambucil)-CHOP protocol could benefit the survival of dogs with multicentric or cranial mediastinal highgrade T-cell lymphoma.
Exploring Social Media Adoption Processes and Factors: Small and Medium Enterprises in the Kingdom of Saudi Arabia

'I" DECLARATION'. 'IV" ACKNOWLEDGEMENTS.V' LIST'OF'TABLES'. 'XII' ' LIST'OF'FIGURES.XIV' DEFINITIONS'AND'ABBERVIATIONS'. XV% CHAPTER'ONE'. '1" INTRODUCTION'. '1" 1.1%Introduction%. %1" 1.2%Significance%of%the%study%and%research%contribution%. %2" 1.3%Background%to%the%study%. %3" 1.3. 1"SMEs"in"the"Kingdom"of"Saudi"of"Arabia"(K.S.A)". "4" 1.3. 2"Social"Media"(SM)"and"its"usage"in"SMEs". "5" 1.3. 3"Current"theoretical"models". "6" 1.4%Knowledge%gap%. %8" 1.5%Objectives%and%research%questions%. %10" 1.6%Structure%of%the%thesis%. %11" 1.7%Chapter%summary%. %14" CHAPTER'TWO'. '15" LITERATURE'REVIEW'. '15" 2.1%Introduction%. %15" 2.2%Social%Media%(SM)%. %18" 2.2.1"SM"Definitions". "18"
Energy analysis of a cylindrical quantum dot in the Hulthen potential

We have investigated energy levels of a cylindrical quantum dot by using a theoretical method. The Hamiltonian of the system in the presence of Hulthen potential has been analysed in cylindrical coordinate system. We obtained the energy levels by using supersymmetric quantum mechanics (SUSY QM) approach.We have investigated energy levels of a cylindrical quantum dot by using a theoretical method. The Hamiltonian of the system in the presence of Hulthen potential has been analysed in cylindrical coordinate system. We obtained the energy levels by using supersymmetric quantum mechanics (SUSY QM) approach.
Electron mobility in silicon nanowires using nonlinear surface roughness scattering model

We theoretically calculate the electron mobility in silicon nanowire metal-oxide-semiconductor field-effect transistor. The calculation of electron mobility is based on the Kubo–Greenwood formulation and the self-consistent solutions of Schrödinger and Poisson equations. Phonon scattering (PHS), Coulomb scattering, and surface roughness scattering (SRS) mechanisms are considered in this study. The nonlinear SRS model is employed because it can reproduce the experimental mobility with realistic surface roughness parameters. The simulation demonstrates that PHS and SRS are both vital scattering mechanisms. The rate of SRS significantly increases with decreasing device size, and SRS is the dominant scattering mechanism in ultra-narrow silicon nanowires.
A comprehensive analysis of methods for assessing polygenic burden on Alzheimer’s disease pathology and risk beyond APOE

Abstract Genome-wide association studies have identified dozens of loci that alter the risk to develop Alzheimer’s disease. However, with the exception of the APOE-ε4 allele, most variants bear only little individual effect and have, therefore, limited diagnostic and prognostic value. Polygenic risk scores aim to collate the disease risk distributed across the genome in a single score. Recent works have demonstrated that polygenic risk scores designed for Alzheimer’s disease are predictive of clinical diagnosis, pathology confirmed diagnosis and changes in imaging biomarkers. Methodological innovations in polygenic risk modelling include the polygenic hazard score, which derives effect estimates for individual single nucleotide polymorphisms from survival analysis, and methods that account for linkage disequilibrium between genomic loci. In this work, using data from the Alzheimer’s disease neuroimaging initiative, we compared different approaches to quantify polygenic disease burden for Alzheimer’s disease and their association (beyond the APOE locus) with a broad range of Alzheimer’s disease-related traits: cross-sectional CSF biomarker levels, cross-sectional cortical amyloid burden, clinical diagnosis, clinical progression, longitudinal loss of grey matter and longitudinal decline in cognitive function. We found that polygenic scores were associated beyond APOE with clinical diagnosis, CSF-tau levels and, to a minor degree, with progressive atrophy. However, for many other tested traits such as clinical disease progression, CSF amyloid, cognitive decline and cortical amyloid load, the additional effects of polygenic burden beyond APOE were of minor nature. Overall, polygenic risk scores and the polygenic hazard score performed equally and given the ease with which polygenic risk scores can be derived; they constitute the more practical choice in comparison with polygenic hazard scores. Furthermore, our results demonstrate that incomplete adjustment for the APOE locus, i.e. only adjusting for APOE-ε4 carrier status, can lead to overestimated effects of polygenic scores due to APOE-ε4 homozygous participants. Lastly, on many of the tested traits, the major driving factor remained the APOE locus, with the exception of quantitative CSF-tau and p-tau measures.
Prävalenz psychischer Störungen und Verlauf der sozialen Integration bei wohnungslosen Männern

All 52 regular users of a shelter in a mediumsized German city underwent a baseline psychiatric examination in 1990. Mental disorders, especially alcohol addiction and schizophrenic disorders, were recorded among 40 (77%). After four years the residential situation and the number and duration of psychiatric hospitalisations was recorded for 42 of these men, 33 of them mentally ill and 9 with no mental disorders. The four-year follow-up revealed that half the mentally ill men were still living in a homeless environment or had died, whereas most users with no mental disorder had a home of their own again. Longer-term hospitalisation or guardianship was found to have a favourable impact on social integration of the homeless mentally ill. Although psychiatric help without the consent of those concerned cannot solve the social problem of homelessness, it can often improve the living situation of homeless mentally ill patients.
Dual-Mode Control for Brushless Doubly Fed Induction Generation System Based on Control-Winding-Current Orientation

Brushless doubly-fed induction generator (BDFIG) has huge potential due to its high reliability and low maintenance costs. In order to meet the requirements of the modern grid code, the BDFIG system should have dual-mode (i.e., operating in both stand-alone and grid-connected modes) capability. Rather than using two separated systems for two modes, this article proposes a unified control architecture for dual-mode operation. Such a unified architecture is based on the stand-alone control-winding (CW) current orientation, and the grid-connected functions are realized by adding three plug-in functional units: 1) the phase-lock function is realized by adding an increment adjustment controller into the CW-angle control; 2) the inrush current during mode switching is suppressed by adding a high-pass feedforward controller into the inner-loop controller; 3) the active power and reactive power are regulated by adding an amplitude-angle controller of CW current. With the proposed unified architecture, the high-performance dual-mode operation is achieved without breaking the original CW-current orientation system, facilitating the overall system design a lot. The detailed analysis and designs are given in this article, and the experiments based on a BDFIG prototype are given to verify the feasibility.
TRANSMISSION DYNAMICS OF DENGUE IN COSTA RICA: THE ROLE OF HOSPITALIZATIONS

For decades, dengue virus has caused major problems for public health officials in tropical and subtropical countries around the world. We construct a compartmental model that includes the role of hospitalized individuals in the transmission dynamics of dengue in Costa Rica. The basic reproductive number, R0, is computed, as well as a sensitivity analysis on R0 parameters. The global stability of the disease-free equilibrium is established. Numerical simulations under specific parameter scenarios are performed to determine optimal prevention/control strategies.
A Secure Crypto-Based Data Outsourcing Model For Monitoring The Smart Environment In Cloud

: With the massive growth in cloud computing, the data owners are interested in outsourcing their databases to the cloud. But the owners and the service providers have some hesitations to trust this domain. Thus it is mandatory to provide data privacy for sensitive data.However, encrypting these private data before outsourcing makes data utilization a difficult task. Several encryption based algorithms were developed by researchers to transfer the data securely from end to end. But existing works focused mainly on single dimensional query or undergo insufficient security guarantee, etc. Thus to overcome above challenges and to monitor the data transmissions in smart environment, a Secured Crypto based Data Outsourcing Model (SCDOM) is proposed. This paper utilizes privacy preservation scheme for detecting anomalies, an enhanced Blowfish technique for implementing encryption and decryption. Here, while receiving user encrypted data, MAC-Message Authentication Code is generated and then transmitted to Third Party Auditor(TPA) for verification. Once keys are verified, the private details are transmitted. From the experimentation results, it is observed that proposed SCDOM provides enhanced results than the conventional methods.
Territórios de morte: visibilidade dos jovens residentes em Porto Alegre vítimas de homicídio nos anos de 2015, 2016 e 2017

Trata-se de pesquisa que visa mapear os homicídios que vitimizam sujeitos residentes em Porto Alegre entre os anos 2015 e 2017, identificando suas principais características, bem como os bairros em que residiam e os locais de ocorrência das mortes. A partir dos dados do Sistema de Informação sobre Mortalidade (SIM) fornecidos pela Secretaria Municipal de Saúde, optou-se pela análise do perfil das vítimas em relação à faixa etária, ao sexo e à raça. Após, com a utilização do software QGis, buscou-se mapear os locais de vida e morte dos jovens assassinados, com idades entre 15 e 29 anos. Assim, foi possível reafirmar a ideia de que os homicídios vitimizam principalmente jovens negros do sexo masculino. Entretanto, a curva da faixa etária apresentou um pico de vítimas que possuem entre 15 e 19 anos, o que não era uma realidade uma década atrás. Ademais, notou-se a diminuição proporcional de vítimas brancas, bem como uma maior representativa de mulheres. Por fim, tanto em relação aos locais de vida como de morte, ao mesmo tempo que se observa uma forte concentração nos bairros Rubem Berta, Restinga, Santa Tereza, Sarandi e Lomba do Pinheiro, também foi possível verificar uma crescente difusão territorial dos homicídios.
Kohesivitas Dan Social Loafing Dalam Pembelajaran Kelompok Pada Siswa SMAN 1 Indralaya

The research aims to determine the relationship between cohesiveness and social loafing on group learning at SMAN 1 Indralaya. The hypothesis of this research as a relationship between cohesiveness and social loafing on group learning at SMAN 1 Indralaya. The subject on this research was student of SMAN 1 Indralaya. The collecting technique using nonprobability sampling with a purposive sampling. The population on this research was 772 students and the sample was 250 students based on Isaac and Micheal theory. Cohesiveness and social loafing was measured by the scale of Cohesiveness and Social Loafing, with reference to the component of cohesiveness from Forsyth (2010) and dimensions of social loafing from Chidambaram and Tung (2005). The result of this research indicate cohesiveness has a relationship with social loafing on students of SMAN 1 Indralaya with a correlation coeffisien - 0.745 and p = 0.000 (p<0.05) . Thus the hypothesis i s accepted.
A first approach for the iron losses building factor determination

In the paper a possibility to determine the iron losses building factor is proposed. The used methodology, which has to be intended as a first approach to the problem, is based on a full experimental approach. Four wound cores, having the same geometrical dimensions, have been assembled as the addition of different number of rings of the same magnetic material. The rings have been obtained by means of a punching process and as a consequence, the four wound cores present a well evident difference in terms of punched edges perimeters. The comparison between the specific losses [W/kg] has been used to obtain the iron loss increase due to the punching process. A building factor defined as the iron loss increase for punched edges length and for sheet can be obtained. The obtained building factor has been used to predict the iron losses in the stator core of an induction motor realized with the same magnetic material used for the wound cores. The comparison between the measured and the predicted results is quite good and it can be considered an interesting starting point for future research.
Modern radiotherapy techniques

Summary The aim of this review article is to present new sophisticated techniques in radiotherapy, which occurred due to the advancement of technology over the past few decades. The paper will provide insight into their advantages and disadvan -tages, the importance of diagnostic imaging modality, precise contouring, treatment planning and control of patients’ posi tion during radiation treatment. The transition from two-dimensional to three-dimensional radiotherapy has allowed con touring of target volume and organs at risk and accurate information on radiation dosage delivered. With a further desire for more precision and protection of healthy tissues, techniques such as intensity modulated radiotherapy (IMRT) and volu metric modulated arc therapy (VMAT) have been developed with the ability to modulate beam intensity. Quality imaging diagnostics is an infallible part of the modern radiotherapy. Image-guided radiotherapy (IGRT) and adaptive radiotherapy enable the delivery of high precision radiation to the target volume and spares organs at risk by correcting interfractional and intrafractional variations. Respiratory gating and tracking technique are useful for tumours that change their position during respiratory cycle. Stereotactic ablative radiotherapy (SABR) is a technique that uses highly conformal high-dose hypofractionated radiation to treat small tumours. In some indication such as the treatment of early stage non-small lung cancer, it competes with radical surgery. SABR is also an important therapeutic modality in the management of oligometa static disease. This paper will briefly discuss proton therapy and its unique physical properties.
Machine Learning Classification of Cerebral Aneurysm Rupture Status with Morphologic Variables and Hemodynamic Parameters.

Purpose To construct a classification model of rupture status and to clarify the importance of morphologic variables and hemodynamic parameters on rupture status by applying a machine learning (ML) algorithm to morphologic and hemodynamic data of cerebral aneurysms. Materials and Methods Between 2011 and 2019, 226 (112 ruptured and 114 unruptured) cerebral aneurysms in 188 consecutive patients were retrospectively analyzed with computational fluid dynamics (CFD). A random forest ML algorithm was applied to the results to create three classification models consisting of only morphologic variables (model 1), only hemodynamic parameters (model 2), and both morphologic variables and hemodynamic parameters (model 3). The accuracy of rupture status classification and the importance of each variable or parameter in the models were computed. Results The accuracy was 77.0% in model 1, 71.2% in model 2, and 78.3% in model 3. The three most important features were projection ratio, size ratio, and aspect ratio in model 1; low shear area ratio, oscillatory shear index, and oscillatory velocity index in model 2; and projection ratio, irregular shape, and size ratio in model 3. Conclusion Classification models of rupture status of cerebral aneurysms were constructed by applying an ML algorithm to morphologic variables and hemodynamic parameters. The model worked with relatively high accuracy, in which projection ratio, irregular shape, and size ratio were important for the discrimination of ruptured aneurysms.Supplemental material is available for this article. © RSNA, 2020.
Compliance as an Integral Part of the Dry Eye Syndrome Prevention Using Silicone Hydrogel Contact Lenses

The probability of dry eye syndrome (DES) in the patients using the Silicone-Hydrogel Contact Lenses is examined in many researches. Therefore, adhering to clinical recommendations is an important factor for DES prevention. The urgent issue is also a comprehensive assessment of functional parameters as pathogenetic base of DES.The objective of the research was tostudy DES development depending on compliance of silicone hydrogel contact lenses users.Matherials and methods. 97 patients (194 eyes) were included into the research. They formed 2 groups: group I with incomplete compliance (36 persons) and group II with complete compliance (61 persons). All the patients underwent the Norn’s test, Schirmer’s test, Jones test, tear film stability was defined. The probability of the dry eye syndrome development due to the subjective signs was also analysed.Results. The reliable decrease in the total (р<0.05) and basale lacrimation (р<0.05) indexes, the increase in osmolarity (р<0.05) and decrease in tear film stability (р<0.05) were detected in the patients who did not follow the clinical guidance during the Silicone-Hydrogel Contact Lenses wearing. In the same group the higher risk of dry eye syndrome development was verified (р<0.05). Conclusion. Compliance disorder in the patients using Silicone-Hydrogel Contact Lenses was found to induce the reliable decrease in total and basale lacrimation, increase in osmolarity and tear stability disorder. All of this factors increase the risk of dry eye syndrome.
Voltage-Stacked Power Delivery Systems: Reliability, Efficiency, and Power Management

In today’s manycore processors, the energy loss of more than 20% may result from inherent inefficiencies of conventional power delivery system (PDS) design. By stacking multiple voltage domains in series to lower the step-down conversion ratio of the off-chip voltage regulator module (VRM) and reduce the energy loss along the path of the power delivery network (PDN), voltage stacking (VS) offers a novel alternative power delivery technique to fundamentally improve power delivery efficiency (PDE). However, VS suffers from aggravated supply voltage noise from the current imbalance, which hinders its adoption. In this article, we investigate practical VS implementation in manycore processors to improve PDE and achieve reliable performance, while maintaining compatibility with advanced power management techniques. We first present the system configuration of a voltage-stacked manycore processor. We then systematically characterize supply voltage noise in VS, identify global, and residual differential currents as its dominant contributors, and calculate the possible worst supply voltage noise. We next propose a hybrid voltage regulation solution, based on a charge-recycling off-chip voltage regulator and distributed integrated voltage regulators, to mitigate supply voltage noise effectively. We also study the compatibility of VS with higher-level power management techniques. Finally, the performance of a voltage-stacked GPU system is comprehensively evaluated. The simulation results show that our approach can achieve 93.5% PDE, reducing the power loss by 13.6% compared to conventional single-layer PDS.
Apparent Diffusion Coefficient of Diffusion Weighted Imaging have Strong Correlation with the Malignancy Grading of Intracranial Tumor

Background and purpose: Accurate imaging diagnosis before surgery is fundamental to determine whether a tumor is benign or malignant. Diagnosis only from structural MRI is not specific. However, the diffusivity of the benign and malignant lesion is different and could be measured by ADC. The Apparent Diffusion Coefficient (ADC) values are calculated automatically by application software and displayed as a parametric map that reflects the degree of diffusion of water molecules through different tissues. The purpose of this study was to analyze the correlation between Diffusion-Weighted Magnetic Resonance Imaging (DWI) and Apparent Diffusion Coefficient (ADC) values with histopathology grading of brain tumors. Material and methods: Pathology reports of intracranial tumor material were correlated with diffusivity of the tumor, and the ADC values, performed within 2 years of post-operative histopathology study. A freehand closed ROI out-lined the whole visible tumor on the most representative slice of ADC maps defined as the slice with the maximum diameter of the solid neoplastic component. ADC values were taken from 2 averages of 2 ROIs. Spearman Correlation test was used to assess the correlation between ADC values with the malignancy grading of the tumor. Result: Low-grade malignant tumors show facilitated diffusion with high ADC values, and high-grade malignant tumors show restricted diffusion with low ADC values. The mean ADC value of Grade I tumor is 1.0799 ± 0.2356 x 10−3 mm2/sec and the mean ADC value of Grade IV tumor is 0.6798 ± 0.23729 x 10−3 mm2/sec. The Spearman correlation test between ADC value and histopathology result shown r = -0.536 and p=0.000 and the test result for ADC value and DWI shown r=-0.706 and p=0.000 (Sig. 0.05). Conclusion: There was strong correlation between DWI and ADC values with histopathology grading of intracranial tumors.
A survey of patients with mental retardation of unknown origin

Introduction: Fragile X syndrome (FXS) is one of the most prevalent genetic causes of developmental disability, representing the most frequent form of inherited severe cognitive deficit. The present study was undertaken to investigate FXS and its prevalence in moderate mentally retarded people in patients. Materials and methods: Nineteen people with moderate mental retardation (MR) who were clinically suspicious to have FXS were screened for FXS by using cytogenetic and molecular methods. Blood samples were collected and cultured in specific culture media. G-Banding method was used for karyotyping. To ensure correct results of cytogenetic testing, four suspected case of FXS were tested by PCR. Results were analyzed using logistic regression analysis. Results: Four patients (4%) were found to express fragile X site at q27.3. The results showed that the relationship of FXS with familial, economic status was not significant, but the relationship of FXS with MR and family history was significant. Conclusion: The frequency of FXS positive cases found in this study is similar to other reports of FXS in preselected patients.