Miracle-dz/UniFAR-FTUs huggingface dataset:
Heat-Treated Micronized Polyethylene Powder for Efficient Oil/Water Separating Filters

The targeted separation of oil/water mixtures is a rapidly growing field of research, mainly due to contaminated water becoming an increasingly important environmental issue. Superhydrophobic materials are highly suited to this application; however, growing efforts are being devoted to developing applicable technologies within a range of research communities. The optimal technical solution is one that combines a high separation efficiency with a straightforward fabrication procedure at a low cost. In this report, micronized polyethylene powder has been utilized as a low-cost hydrophobic material to manufacture easy-to-fabricate filters. The effect of heating and solvent addition on the water repellence behaviour has been investigated, according to which the optimum fabrication conditions were determined. The filters show high water repellence (WCA = 154°) and efficient oil/water separation (~99%). The filters are designed to provide a readily achievable approach for the separation of oils (hydrophobic solvents) from water in a range of potential applications.
Upregulation of microRNA-451 attenuates myocardial I/R injury by suppressing HMGB1

Both MicroRNAs and HMGB1 took part in pathological process of myocardial I/R injury though several signaling pathways. We hypothesized that mircoRNA451 (miR-451), a group of small non-coding RNAs, could improve this injury by inhibiting HMGB1. Male SD rats were randomly distributed into 5 groups and subjected to I/R process. After 24 hours of reperfusion injury, the serum content of CK and LDH, the content of MDA in tissue and activity of SOD were detected; The infarcted areas were defined by TTC staining and Evans Blue; TUNEL staining and cleaved-Caspase 3 were used to test apoptosis; HMGB1 was detected by real-time fluorescence quantitative PCR and Western Blotting. Compared with the I/R and I/R+Ad-GFP group, upregulation of miR-451 could reduce the infarcted areas, cardiomyocytes apoptosis index, expression of cleaved-caspase 3 and content of CK and LDH significantly(P<0.05); Meanwhile, upregulation of miR-451 could also obviously inhibit HMGB1, the increase of MDA and the decrease of SOD (P<0.05). So this study revealed that upregulation of miR-451 could prevent myocardial I/R injury by suppressing HMGB1.
Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model

Dysregulation of histone demethylase Jumonji-C domain-containing protein 5 (JMJD5) has been identified as a great effect on tumorigenesis. Silibinin is a commonly used anti-hepatotoxic drug and exhibits anticancer effect in various cancers. However, the antitumor mechanism between silibinin and JMJD5 in oral squamous cell carcinoma (OSCC) remains unclear. In this study, the clinical significance of JMJD5 on OSCC patients was assessed through tissue microarray. Furthermore, mice bearing patient-derived tumor xenografts (PDTXs) and tongue cancer cell lines were treated with silibinin and evaluated for tumor growth and JMJD5 expression. High expression of JMJD5 in oral cancer was significantly associated with tumor size (P = 0.0241), cervical node metastasis (P = 0.0001) and clinical stage (P = 0.0002), was associated with worse survival rate compared with that of the total cohort (P = 0.0002). Collectively the data indicate that JMJD5 expression may be suitable for detection of unfavorable prognosis in OSCC patients, based in part on its apparent role as a marker of metastasis. In addition, silibinin inhibits cancer growth in vitro and in PDTX models. Furthermore, metastasis-associated protein 1 (MTA1) could regulate the expression for JMJD5 and had a positive correlation with JMJD5. Moreover, silibinin could downregulate JMJD5 and MTA1 in oral cancer. Present study thus identifies that JMJD5 might be an essential prognostic indicator and therapeutic target against OSCC progression. In addition, silibinin is a potential candidate among novel chemotherapeutic agents or adjuvants for modulating JMJD5 in OSCC, through a mechanism likely involving MTA1/JMJD5 axis.
Evaluation of Changes in Gut Microbiota in Patients with Crohn’s Disease after Anti-Tnfα Treatment: Prospective Multicenter Observational Study

Background: Crohn’s disease is believed to result from the interaction between genetic susceptibility, environmental factors and gut microbiota, leading to an aberrant immune response. The objectives of this study are to evaluate the qualitative and quantitative changes in the microbiota of patients with Crohn’s disease after six months of anti-tumor-necrosis factor (anti-TNFα) (infliximab or adalimumab) treatment and to determine whether these changes lead to the recovery of normal microbiota when compared to a control group of healthy subjects. In addition, we will evaluate the potential role of the Faecalibacterium prausnitzii/Escherichia coli and Faecalibacterium prausnitzii/Clostridium coccoides ratios as indicators of therapeutic response to anti-TNFα drugs. Methods/Design: This prospective multicenter observational study will comprise a total of 88 subjects: 44 patients with Crohn’s disease scheduled to start anti-TNFα treatment as described in the drug specifications to control the disease and 44 healthy individuals who share the same lifestyle and eating habits. The presence of inflammatory activity will be determined by the Harvey-Bradshaw index, analytical parameters in blood, including C-reactive protein, and fecal calprotectin levels at commencement of the study, at three months and at six months, allowing the classification of patients into responders and non-responders. Microbiota composition and the quantitative relationship between Faecalibacterium prausnitzii and Escherichia coli and between Faecalibacterium prausnitzii and Clostridium coccoides group as indicators of dysbiosis will be studied at inclusion and six months after initiation of treatment using ultra sequencing with Illumina technology and comparative bioinformatics analysis for the former relationship, and digital droplet PCR using stool samples for the latter. Upon inclusion, patients will complete a survey of dietary intake for the three days prior to stool collection, which will be repeated six months later in a second collection to minimize dietary bias. Discussion: In this study, massive sequencing, a reliable new tool, will be applied to identify early biomarkers of response to anti-TNF treatment in patients with Crohn’s disease to improve clinical management of these patients, reduce morbidity rates and improve efficiency.
Somatic Tinnitus and Manual Therapy: A Systematic Review

Background: In 2016, a systematic review was conducted to examine the effects of physical therapy interventions on individuals with subjective tinnitus. However, the research study investigated subjective tinnitus that may not have had a somatic origin. In addition, only one of the included studies specifically assessed the effectiveness of manual therapy. Objectives: The purpose of this systematic review was to examine the effects of manual therapy techniques on individuals with somatic tinnitus. Methods: A search was performed using the following databases: CINAHL Complete, ProQuest Medical Library, and PubMed. The search terms were “somatic tinnitus” OR “somatosensory tinnitus” AND “manual therapy”. An evaluation of the evidence level for each included article was conducted using the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence, and an evaluation of the methodological rigor for each included article was conducted using criteria adapted by Medlicott and Harris. Results: A qualitative synthesis was ultimately performed on eight articles. The manual therapy techniques included in this systematic review were cervical mobilizations, myofascial techniques, osteopathic manipulations, soft tissue techniques, and manual therapy as developed by the School of Manual Therapy Utrecht. This systematic review also included complementary treatment approaches such as patient education, therapeutic exercise, transcutaneous electrical neurostimulation, and home exercise programs. Conclusion: Manual therapy appears to be an effective intervention for individuals with somatic tinnitus, especially if they have co-varying tinnitus or tinnitus sensitization. In addition, a multimodal intervention approach may be the ideal way in which to positively impact an individual’s activities of daily living.
Advance Intelligent Video Surveillance System (AIVSS): A Future Aspect

Over the last few decades, remarkable infrastructure growths have been noticed in secu- rity-related issues throughout the world. So, with increased demand for Security, Video-based Surveillance has become an important area for the research. An Intelligent Video Surveillance system basically censored the performance, happenings, or changing information usually in terms of human beings, vehicles or any other objects from a distance by means of some electronic equipment (usually digital camera). The scopes like prevention, detection, and intervention which have led to the development of real and consistent video surveillance systems are capable of intelligent video processing competencies. In broad terms, advanced video-based surveillance could be described as an intelligent video pro- cessing technique designed to assist security personnel’s by providing reliable real-time alerts and to support efficient video analysis for forensic investigations. This chapter deals with the various requirements for designing a robust and reliable video surveillance system. Also, it is discussed the different types of cameras required in different environmental con - ditions such as indoor and outdoor surveillance. Different modeling schemes are required for designing of efficient surveillance system under various illumination conditions.
Leaf epidermal microcharacters of the Old World species of Lotus (Leguminosae: Loteae) and their systematic significance

Some perennial species of Lotus L. (Leguminosae: Loteae) from the Old World constitute an important forage resource. The epidermal microcharacters of 15 species belonging to the Old World Lotus angustissimus L. , L. corniculatus L. , L. creticus L. and L. peregrinus L. groups were described to compute the phenetic relationships, and to compare these results with previous classifications and phylogenetic hypotheses. Data on epidermal cells, stomata, stomatal indeces and trichomes were recorded and summarised in tables and illustrations. To test the taxonomic value of epidermal features and to establish the phenetic relationships, two numerical analyses were performed. Phenograms by the unweighted pair-group method (UPGMA) of clustering were generated. Results of the numerical analysis using a basic data matrix (15 operational taxonomic units × 15 epidermal characters) suggested that epidermal characteristics make it possible to establish species' and species groups' relationships; however, they were not totally coincident with previous classifications. An additional analysis using epidermal characters plus other morphological characters from leaves, flowers, fruits and seeds led to establish species' and species groups' relationships. Results generated by the latter analysis demonstrated that epidermal traits, together with other characters, are useful and informative for testing species clustering. Phenetic results coincide with earlier classifications and chromosome-number studies and accord well with a previous phylogenetic hypothesis in showing the close relationship among species of the Old World Lotus groups included in this study.
Distinct Responses to Light in Plants

The development of almost every living organism is, to some extent, regulated by light. When discussing light regulation on biological systems, one is referring to the sun that has long been positioned in the center of the solar system. Through light regulation, all life forms have evolved around the presence of the sun. As soon our planet started to develop an atmospheric shield against most of the detrimental solar UV rays, life invaded land, and in the presence of water, it thrived. Especially for plants, light (solar radiation) is the source of energy that controls a high number of developmental aspects of growth, a process called photomorphogenesis. Once hypocotyls reach soil′s surface, its elongation deaccelerates, and the photosynthetic apparatus is established for an autotrophic growth due to the presence of light. Plants can sense light intensities, light quality, light direction, and light duration through photoreceptors that accurately detect alterations in the spectral composition (UV-B to far-red) and are located throughout the plant. The most well-known mechanism promoted by light occurring on plants is photosynthesis, which converts light energy into carbohydrates. Plants also use light to signal the beginning/end of key developmental processes such as the transition to flowering and dormancy. These two processes are particularly important for plant´s yield, since transition to flowering reduces the duration of the vegetative stage, and for plants growing under temperate or boreal climates, dormancy leads to a complete growth arrest. Understanding how light affects these processes enables plant breeders to produce crops which are able to retard the transition to flowering and avoid dormancy, increasing the yield of the plant.
A novel self-assembling peptide for hemostasis during endoscopic submucosal dissection: a randomized controlled trial

Abstract Background Endoscopic submucosal dissection (ESD) is associated with a risk of bleeding. Bleeding is usually treated with diathermy, although this does carry a risk of mucosal thermal injury. Purastat is a topical hemostat that may be effective in controlling bleeding during ESD, thereby reducing the use of heat therapy. The aim of this study was to assess the reduction in heat therapy used in the interventional group (Purastat) compared with the control group. The secondary aims were to compare the procedure length, time for hemostasis, delayed bleeding rate, adverse events, and wound healing between the groups. Methods This was a single-center randomized controlled trial of 101 patients undergoing ESD. Participants were randomized to a control group where diathermy was used to control bleeding or an interventional group where Purastat could be used. Follow-up endoscopy was performed at 4 weeks to assess wound healing. Results There was a significant reduction in the use of heat therapy for intraprocedural hemostasis in the interventional group compared with controls (49.3 % vs. 99.6 %, P < 0.001). There were no significant differences in the procedure length, time for hemostasis, and delayed bleeding rate between the groups. Complete wound healing at 4 weeks was noted in 48.8 % of patients in the interventional group compared with 25.0 % of controls (P = 0.02). Conclusions This study has demonstrated that Purastat is an effective hemostat that can reduce the need for heat therapy for bleeding during ESD. It may also have a role in improving post-resection wound healing.
Prevalence and Socio-Demographic, Academic, Health and Lifestyle Predictors of Illicit Drug/s Use among University Undergraduate Students in Finland

Illicit drug/s use (IDU) among university students is a public health concern. We assessed the associations between socio-demographic, academic, and health and lifestyle characteristics (independent variables) and regular, occasional or never IDU (dependent variables). Data were collected across seven faculties (1177 students) at the University of Turku (Finland) via an online questionnaire. About 1.5% of the sample had regular IDU, 19% occasional IDU, and 79% never IDU. Independent predictors of ever (lifetime) IDU included males [adjusted odds ratio (AOR) 1.82, P = 0.001], not living with parents (AOR 2.59, P < 0.001), singles (AOR 0.51, P < 0.001), lower religiosity (AOR 1.49, P = 0.022), better self-rated general health (AOR 0.41, P = 0.003), higher health awareness (AOR 1.93, P = 0.014), more depressive symptoms (AOR 1.82, P = 0.004), daily smokers (AOR 3.69, P < 0.001), heavy episodic drinking (AOR 2.38, P < 0.001) and possible alcohol dependency (AOR 2.55, P < 0.001). We observed no independent associations between ever IDU with age, study discipline, perceived stress or academic performance. The 20.5% ever IDU is concerning. The compelling independent predictors of ever IDU included not living with parents, lower religiosity, daily smokers, heavy episodic drinking and possible alcohol dependency (AOR range 2.38–3.69). Education and prevention need to emphasize the negative consequences to reinforce abstinence from IDU. Health promotion could focus on beliefs and expectations about IDU and target students at risk for successful efforts.
Frequent Recombination Events in Leishmania donovani: Mining Population Data

The Leishmania donovani species complex consists of all L. donovani and L. infantum strains mainly responsible for visceral leishmaniasis (VL). It was suggested that genome rearrangements in Leishmania spp. occur very often, thus enabling parasites to adapt to the different environmental conditions. Some of these rearrangements may be directly linked to the virulence or explain the reduced efficacy of antimonial drugs in some isolates. In the current study, we focused on a large-scale analysis of putative gene conversion events using publicly available datasets. Previous population study of L. donovani suggested that population variability of L. donovani is relatively low, however the authors used masking procedures and strict read selection criteria. We decided to re-analyze DNA-seq data without masking sequences, because we were interested in the most dynamic fraction of the genome. The majority of samples have an excess of putative gene conversion/recombination events in the noncoding regions, however we found an overall excess of putative intrachromosomal gene conversion/recombination in the protein coding genes, compared to putative interchromosomal gene conversion/recombination events.
Ammonia: emission, atmospheric transport and deposition

The global emission of ammonia (NH 3 ) is about 54 Mt N. The major global sources are excreta from domestic animals and fertilizers, but oceans, biomass burning and crops are also important. About 60% of the global NH 2 emission is estimated to come from anthropogenic sources. NH 3 -N emissions are of the same order as the NO x -N emissions on both global and European scales. Emitted NH 3 returns to the surface mainly in the form of dry deposition of NH 3 and wet deposition of ammonium (NH 4 + ). In countries with high NH 3 emission densities, dry deposition of NH 3 from local sources and wet deposition of NH 4 from remote sources dominate the deposition. In countries with low NH 3 emission densities only wet deposition of NH 4 + from remote sources dominates the deposition. Surface exchange of NH 3 is essentially bi-directional, depending on the NH 3 compensation point concentration of the vegetation and the airborne concentration. In general, the compensation point is larger for agricultural than semi-natural plants, and varies with plant growth stage. According to basic thermodynamics the leaf tissue or stomatal compensation point of NH 3 doubles for each increase of 5 °C. However, exchange of NH 3 does not only occur through the stomata, but it can also be deposited to leaf surfaces, as well as emitted back to the atmosphere from drying leaf surfaces. Atmospheric transport and deposition models can be used to interpolate NH 3 concentrations and depositions in space and time, to calculate import/export balances and to estimate past or future situations. Adverse effects on sensitive ecosystems caused by high N deposition can be reduced by lowering the emissions and, to a limited extent, also by removing sources close to the ecosystem to be protected.
Identification of high‐use habitat and threats to leatherback sea turtles in northern waters: new directions for conservation

Incidental capture in fisheries threatens many marine vertebrates, however, conservation cannot be effective without identifying major sources of mortality. For the critically endangered leatherback turtle (Dermochelys coriacea), a reliance on fisheries observer data and an absence of behavioural data sets corresponding to a large and diverse sample of animals have focused conservation efforts on a very limited part of the species marine habitat. Using the largest satellite telemetry data set for Atlantic leatherbacks, morphometrics from foraging animals and entanglement records, we show annual return migrations to key feeding areas by males, females and juveniles, and demonstrate the importance of northern latitudes to leatherbacks. We show that leatherbacks are vulnerable to entanglement in northern coastal and shelf waters, where turtle–fishery interactions represent a greater threat to this species than previously recognized. Unless conservation efforts expand to coastal and shelf areas, present efforts alone will not be sufficient to save the species.
Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45lowCD271+ Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation

Skeletal aging is associated with reduced proliferative potential of bone marrow (BM) multipotential stromal cells (MSCs). Recent data suggest the involvement of type 1 interferon (IFN1) signalling in hematopoietic stem cell (HSC) senescence. Considering that BM-HSCs and BM-MSCs share the same BM niche, we investigated IFN1 expression profile in human BM-MSCs in relation to donor age, culture-expansion and IFN1 (α and β) stimulation. Fluorescence-activated cell sorting was used to purify uncultured BM-MSCs from younger (19–41, n = 6) and older (59–89, n = 6) donors based on the CD45lowCD271+ phenotype, and hematopoietic-lineage cells (BM-HLCs, CD45+CD271−) were used as controls. Gene expression was analysed using integrated circuits arrays in sorted fractions as well as cultured/stimulated BM-MSCs and Y201/Y202 immortalised cell lines. IFN1 stimulation led to BM-MSC growth arrest and upregulation of many IFN1-stimulated genes (ISGs), with IFNβ demonstrating stronger effects. Uncultured MSCs were characterised by a moderate-level ISG expression similar to Y201 cells. Age-related changes in ISG expression were negligible in BM-MSCs compared to BM-HLCs, and intracellular reactive oxygen species (ROS) levels in BM-MSCs did not significantly correlate with donor age. Antiaging genes Klotho and SIRT6 correlated with more ISGs in BM-MSCs than in BM-HLCs. In patients with osteoarthritis (OA), BM-MSCs expressed considerably lower levels of several ISGs, indicating that their IFN1 signature is affected in a pathological condition. In summary, BM-MSCs possess homeostatic IFN1 gene expression signature in health, which is sensitive to in vitro culture and external IFN1 stimulation. IFN signalling may facilitate in vivo BM-MSC responses to DNA damage and combating senescence and aberrant immune activation.