Miracle-dz/UniFAR-FTUs huggingface dataset:
Chromosomal insertion sites for phages and plasmids

Bacteriophages insert their DNA into host chromosomes either through transposition (as in phage Mu) or through site-specific recombination (as in phage X). Whereas Mu can insert almost anywhere along the chromosome, X has a single highly preferred chromosomal site. Certain plasmids also insert into chromosomes by site-specific recombination. The site-specific recombinases used generally belong to the integrase family, whose members show some sequence homology and conservation of reaction mechanism, indicating descent from a common ancestor (2, 8, 12, 19). This minireview examines some chromosomal sites with known nucleotide sequences. The purpose is not to prepare an exhaustive catalog but to look for common trends. The focus is on chromosomal (attB) sites, not on the phage (attP) sites. Nevertheless, interpretation requires compari-
Promoting engagement in online courses: What strategies can we learn from three highly rated MOOCS

Although past research has sought to identify the factors of student engagement in traditional online courses, two questions remained largely unanswered with regard to Massive Open Online Courses (MOOCs): do the factors that could influence student engagement in traditional online courses also apply to online courses that are massive and open? What factors do students consider important in terms of their perceived ability to promote a satisfying or engaging online learning experience? This paper reports a case study of three top-rated MOOCs in the disciplines of programming languages, literature, and arts & design in order to address these very questions. Using a mixed methods approach that combines participant observation with analysis of reflection data from 965 course participants, this paper seeks to understand the factors behind the popularity of these MOOCs. Five factors were found. These include the following, ranked in terms of importance: (1) problem-centric learning with clear expositions, (2) instructor accessibility and passion, (3) active learning, (4) peer interaction, and (5) using helpful course resources. The specific design strategies pertaining to each factor are further discussed in this paper. These strategies can provide useful guidance for instructors and are a worthwhile subject for further experimental validation.
Inactivation of root canal medicaments by dentine, hydroxylapatite and bovine serum albumin.

AIM This study examined and compared the inhibition of the antibacterial effect of saturated calcium hydroxide solution, chlorhexidine acetate and iodine potassium iodide by dentine, hydroxylapatite and bovine serum albumin. METHODOLOGY Enterococcus faecalis strain A197A prepared to a suspension of 3 x 10(8) cells per ml in 0.5% peptone water was used. Fifty microL of saturated calcium hydroxide solution, 0.05% chlorhexidine acetate or 0.2/0.4% iodine potassium iodide were incubated at 37 degrees C with 28 mg dentine powder (DP), hydroxylapatite (HA) or bovine serum albumin (BSA) in 50 microL water for 1 h before adding 50 microL of the bacterial suspension. Samples for bacterial culturing were taken from the suspension 1 and 24 h after adding the bacteria. In further experiments, the amount of dentine was stepwise reduced from 28 mg 150 microL-1 to 2.8 mg 150 microL-1. RESULTS Calcium hydroxide was totally inactivated by the presence of 28 mg of DP, HA or BSA. Chlorhexidine (0.05%) was strongly inhibited by BSA and slowed down by dentine. However, HA had little or no inhibitory effect on chlorhexidine. The antibacterial effect of 0.2/0.4% iodine potassium iodide on E. faecalis was totally inhibited by dentine (28 mg), but was practically unaffected by HA or BSA. A stepwise reduction of dentine from 28 mg 150 microL-1 to 2.8 mg 150 microL-1 was followed by a similar reduction of the inhibition of the antibacterial activity of chlorhexidine. Iodine potassium iodide was not inhibited at all with dentine amounts less than 28 mg. However, the effect of saturated calcium hydroxide solution was totally eliminated by dentine, in all four concentrations. CONCLUSION Inhibition by dentine of the antibacterial activity of calcium hydroxide, chlorhexidine and iodine potassium iodide occurs by different mechanisms. Different components of dentine may be responsible for the inhibition of these three medicaments. Calcium hydroxide was particularly sensitive to inhibition by both inorganic and organic compounds.
Joint Estimation of IQ Parameters and Channel Response for OFDM Systems

In this paper, we develop a new algorithm to jointly estimate the channel impulse response and inphase-quadrature (IQ) imbalances for OFDM systems. The estimation algorithm is based on the expectation maximization(EM) algorithm, exploiting information from the pilot symbols and detected data symbols in a systematic fashion. To reduce the complexity of the estimation algorithm, a suboptimal scheme is also introduced. The results indicate that the proposed algorithms achieve a significant improvement in the bit error rate (BER) performance when compared with conventional data-aided algorithms.
An Overview of Different Job Scheduling Heuristics Strategies for Cloud Computing Environment

Cloud Computing, the long-held vision of computing as a utility, has the prospective to renovate a large part of the IT industry, making software even more attractive as a service and shaping the way IT hardware is premeditated and purchased. Developers with novel ideas for new Internet services no longer need the large capital outlays in hardware to install their service or the human expense to control it. They require not be concerned about overprovisioning for a service whose popularity does not gather their predictions, thus wasting costly resources, or underprovisioning for one that becomes wildly admired, thus missing prospective customers and returns. Job scheduling system problem is a nucleus and demanding issue in Cloud Computing. How to utilize Cloud Computing resources proficiently and gain the maximum profits with job scheduling system is one of the Cloud computing service providers’ ultimate objectives. This paper discusses the QoS requirements of Cloud computing resources users’ jobs and different strategies to gain the maximum profits by offering Cloud computing resources. In Cloud computing, users with dissimilar service requirements often need to bargain with service provider via Service Level Agreement (SLA). The unique pay-as-you-go billing approach in Cloud computing challenges resource provisioning for service providers. The cloud computational environment is very suit to meet the computational burdens of large, diverse groups of jobs. And the job scheduling problem in it has been a research hotspot in recent years. Some heuristic techniques have been used to optimize it However, selecting the finest one to use in a given environment remains a tricky problem, because comparisons are often clouded by different underlying assumptions in the original study of each algorithm. Some comparisons have been made to them, but some new algorithms are not included in the comparisons. So, in this paper, four popular researched algorithms are discussed. The four heuristics are Genetic Algorithm (GA), Ant Colony Optimization Algorithm (ACO), Particle Swarm Optimization (PCO) Algorithm and Simulated Annealing Algorithm (SA).
EVA - A STUDY OF SELECTED COMPANIES IN INDIA

Economic Value Added (EVA) is an improved measure of checking the company performance so that the stakeholders can decide that the company is generating or destroying their wealth. EVA is latest and modern measure technique to know the efficiency of the companies that whether they are maximizing or reducing the value of shareholders wealth. Therefore this paper is designed with an attempt to know that which companies is the wealth generator or destroyer for the shareholders. The main objective of the study is to rank the companies on the basis of EVA. Therefore a sample of fifty companies has been taken from NSE listed Companies for the period of 2005-2010 from Stock Market and ranked according to EVA as wealth generating companies or wealth destroying companies as in our fifty sample companies only three companies have disclosed Economic Value Added in their annual reports. This paper is mainly focuses on the shareholders benefit so that they can take decision to continue their investment with the same companies or not.
Chronic placental insufficiency in the fetal guinea pig affects neurochemical and neuroglial development but not neuronal numbers in the brainstem: A new method for combined stereology and immunohistochemistry

This study has examined the development of the brainstem in a suboptimal intrauterine environment induced via chronic placental insufficiency in the fetal guinea pig. Placental insufficiency was produced by unilateral ligation of the maternal uterine artery at mid‐gestation (term = 66–68 days) resulting in the production of growth‐retarded fetuses that are chronically hypoxic and malnourished. The structural and neurochemical development of brainstem nuclei either directly or indirectly related to cardiorespiratory control were analysed by using new stereological methods and immunohistochemistry. A technique was devised to enable the procedures to be performed on alternate frozen sections.
Recent advancements in clustering protocols for wireless sensor network

Wireless sensor network is an unionized structure that's formed via-massive wide variety of small lightweight densely deployed sensor nodes in hostile environment for monitoring tracking and detection and a sink node for gathering the sensed data for decision making process. As sensor nodes' batteries, having short duration of energy and can't be recharged. Hence, with the view to maintain network lifetime acceptably high, it emerge noticeably important to have specialized energy aware routing protocols to attain high scalability in such environments. Rather than direct and flat routing, hierarchical cluster based routing protocols make great extent contribution to increment the overall system scalability, robustness, lifetime, and energy efficiency, and also does load balancing and data aggregation with the intention to decrement the number of messages forwarded to the BS. This paper surveys a comprehensive review on recently discovered routing protocols proposed for clustering using various approaches for cluster head selection, for forming clusters and for routing the data, along with their advantages.
KEPUASAN MEMEDIASI PENGARUH KUALITAS PRODUK DAN LAYANAN TERHADAP LOYALITAS NASABAH

Currently, loyalty has become the central issue for the banking business because it can influence the existence of the organization in the future and it can make customers conduct re-purchases. Product quality, service quality and even customer satisfaction is one of the criteria in order to gain customer loyalty. The purpose of this research is to find out the influence of product quality and service quality which is mediated by the satisfaction to the customer loyalty. The respondents are all customers of PT Bank Mayapada Cabang Darmo Surabaya. The sample collection technique is based on coincidence and the samples are 100 bank customers. The analysis technique has been done by using path analysis. The result of the test shows that product quality and service quality have significant and direct influence to the loyal customers of Bank Mayapada Cabang Darmo Surabaya. When it is mediated by the customer satisfaction, product quality and service quality, these variables have an influence to the customer loyalty. This result reflects that product quality and service quality can have direct and indirect influence (mediated) by the customer satisfaction to the customer loyalty of Bank Mayapada Cabang Darmo Surabaya. Keywords: Product Quality, Service Quality, Satisfaction and Customers’ Loyalty.
Factors Affecting Efficiency of Performance Management System in Public Service Institutions

The performance management system has its specificities in public service institutions, which arise especially from the nature of the institution's work and from various interactions with interested parties. This paper focuses on the analysis of some factors that affect the efficiency of performance management systems in public service institutions to a various degree. Results are based on a survey that verified hypotheses related to three factors affecting the efficiency of the performance management system in public service institutions – suitability of using standard models of performance management, role of social responsibility in the performance management and interconnection of organizational and individual performance objectives in public service institutions
Deconstructing Informality: A Response to Vulnerability or an Optimal Choice?

The rapid growth of informal employment in China in recent decades has attracted attention, but to understand its implications, the concept of informality must be deconstructed. We reclassify employment status into three categories: salaried workers who have long-term contracts; the self-employed; and causal workers without long term contracts (working in either the formal or the informal sector). The monthly earnings of the self-employed are much (47%) higher than those casual employees. Self-employment is not necessarily a misfortune and the flexibility it provides may be optimal for some kinds of workers. For example, the self-employed are more likely to be disabled and to have young families. Institutionally, it is still difficult for casual workers and most rural-urban migrant workers to embark on business ownership. Although a large group of rural-urban migrants are employees with longer term contracts, their rural registration (hukou) means they lack the social protection of urban residents. The labour force with rural hukou is more likely to fall into the informal sector and, within that sector, is most likely to be engaged in casual labouring jobs. Policies to support small businesses may be warranted given the detrimental impacts of informality on casual workers. Experimental interventions could be tried along the lines of those used in Peru to provide funds to support entrepreneurial activities by this group to lift themselves out of a poverty trap into more sustainable employment. Skill training, encouragement for innovation, tax credits and reducing institutional constraints on starting up small business should be all considered.
Analysis of a multiple nuclear dots pattern in a large cohort of dermatological patients.

BACKGROUND Anti-multiple nuclear dots (MND) antibodies are the markers of primary biliary cirrhosis (PBC), but can also be found in patients with other autoimmune diseases. METHODS We looked for MND in 9189 sera belonging to 6240 patients stored for autoimmune diseases with prevalent cutaneous features. RESULTS Fifty sera proved anti-MND-positive and came from 15 different patients: 6 had lupus erythematosus, 2 dermatomyositis, 2 lichen planus, 1 stroke, 1 telogen effluvium, 1 autoimmune thrombocytopenia, and 2 undifferentiated connective tissue disease. CONCLUSIONS Anti-MND antibodies can be found not only in patients with PBC, but in connective tissue diseases as well. They can be associated with other fluoroscopic patterns and their titers can vary over the years, never correlating with the disease activity or with particular cutaneous features. Although anti-MND antibodies found are directed to the Sp100 antigen of the nuclear dots, it remains unclear whether their molecular target is the same amino-acid domain as in PBC.
A Framework of Risk in Global IT Projects and Mitigation Strategies from Service-Oriented Architecture

Global Information Technology (IT) projects span multiple locations that are typically employing different practices, adhering to different standards, and using different technologies – at the same time operating in highly diverse cultures. Differences such as these are prevalent factors that increase risk on global IT projects. Further, they are prone to changing continuously over the course of a project, with the consequence that risk becomes highly unpredictable and dynamic. This chapter proposes a framework to characterize risks within the people-process-technology-external elements of a global IT project. The framework gives particular consideration to risks that arise from interactions of multiplicities within and between those elements (i.e. dynamic risks). The principles of Service-Oriented Architecture (SOA) are adopted to propose specific strategies for mitigation of these dynamic risks. Two case studies further illustrate how those strategies can mitigate the risks.
Application of a Fas Ligand Encoding a Recombinant Adenovirus Vector for Prolongation of Transgene Expression

ABSTRACT An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ectopic expression of functional mFasL in vector-transduced cells does not appear to confer, by itself, an immunoprivileged site sufficient to mitigate adenovirus vector immunogenicity.
Factors Influencing Survival and Mark Retention in Postmetamorphic Boreal Chorus Frogs

The ability to track individual animals is crucial in many field studies and often requires applying marks to captured individuals. Toe clipping has historically been a standard marking method for wild amphibian populations, but more recent marking methods include visual implant elastomer and photo identification. Unfortunately, few studies have investigated the influence and effectiveness of marking methods for recently metamorphosed individuals and as a result little is known about this life-history phase for most amphibians. Our focus was to explore survival probabilities, mark retention, and mark migration in postmetamorphic Boreal Chorus Frogs (Psuedacris maculata) in a laboratory setting. One hundred forty-seven individuals were assigned randomly to two treatment groups or a control group. Frogs in the first treatment group were marked with visual implant elastomer, while frogs in the second treatment group were toe clipped. Growth and mortality were recorded for one year and resulting data were analyzed using known-fate models in Program MARK. Model selection results suggested that survival probabilities of frogs varied with time and showed some variation among marking treatments. We found that frogs with multiple toes clipped on the same foot had lower survival probabilities than individuals in other treatments, but individuals can be marked by clipping a single toe on two different feet without any mark loss or negative survival effects. Individuals treated with visual implant elastomer had a mark migration rate of 4% and mark loss rate of 6%, and also showed very little negative survival impacts relative to control individuals.
Impact of Dilution on Microbial Community Structure and Functional Potential: Comparison of Numerical Simulations and Batch Culture Experiments

ABSTRACT A series of microcosm experiments was performed using serial dilutions of a sewage microbial community to inoculate a set of batch cultures in sterile sewage. After inoculation, the dilution-defined communities were allowed to regrow for several days and a number of community attributes were measured in the regrown assemblages. Based upon a set of numerical simulations, community structure was expected to differ along the dilution gradient; the greatest differences in structure were anticipated between the undiluted–low-dilution communities and the communities regrown from the very dilute (more than 10−4) inocula. Furthermore, some differences were expected among the lower-dilution treatments (e.g., between undiluted and 10−1) depending upon the evenness of the original community. In general, each of the procedures used to examine the experimental community structures separated the communities into at least two, often three, distinct groups. The groupings were consistent with the simulated dilution of a mixture of organisms with a very uneven distribution. Significant differences in community structure were detected with genetic (amplified fragment length polymorphism and terminal restriction fragment length polymorphism), physiological (community level physiological profiling), and culture-based (colony morphology on R2A agar) measurements. Along with differences in community structure, differences in community size (acridine orange direct counting), composition (ratio of sewage medium counts to R2A counts, monitoring of each colony morphology across the treatments), and metabolic redundancy (i.e., generalist versus specialist) were also observed, suggesting that the differences in structure and diversity of communities maintained in the same environment can be manifested as differences in community organization and function.
Design of an accurate pedestrian detection system using modified HOG and LSVM

This paper focuses on detecting a pedestrian in an image. This real time application aims for high detection accuracy as well as faster computation. For higher accuracy and detection rate Histogram of Oriented Gradients (HOG) algorithm is used. Further, Linear Support Vector Machine (LSVM) classification is used for faster and reliable classification. Since the HOG algorithm is compute expensive several modifications have been made in order to get the best results for real time application. We have used bilinear interpolation and L2-normalisation for more reliable output. Further since the data is linearly separable a LSVM is designed in Matlab. The proposed algorithm provides an accuracy of 93.27% with a high true positive rate of 92.27% and a minor false positive rate of 4%.
Asset Pricing Under Ambiguity

One of the main problems in decision making is to investigate how a decision maker makes a choice among a set of feasible acts, when uncertainty is about the realization of states of nature, for example, in portfolio selection, investors have to choose an action, from a non-empty finite set of possible actions. The consequence of each action depends on which one of a given non-empty set Ω of states of nature comes true. Suppose that all the investors share the same well-known probability distribution p defined on Ω. As introduced in the seminal work of Markowitz (1952), the basic portfolio selection problem is to minimize the risk of portfolio under a constraint for its expected return or, equivalently, to maximize that expected return under a risk constraint. Moreover, when investors are deciding whether or not to invest in a particular stock, they want to know how the stock will contribute to the risk and expected return of their portfolios. The capital asset pricing model (Eichberger & Harper, 1997) provides an expression which relates the expected return of an asset to its systematic risk. Supposing now that each investor, in addition to the objective official probability measure p on Ω, wants to decide also referring to a subjective probability measure on that set, which reflects his personal ideas. The purpose of the present paper is to give an advancement in asset pricing by the demonstration of the capital asset pricing model with the additional hypothesis that each agent has also a subjective probability distribution on the