Miracle-dz/UniFAR-FTUs huggingface dataset:
Terminal deoxynucleotidyl transferase activity in blastic phase of chronic myelogenous leukemia.

Twenty-four Philadelphia chromosome-positive, chronic myelogenous leukemia patients were examined for DNA polymerase activity, terminal deoxynucleotidyl transferase (terminal transferase) activity, cell surface markers, morphology of peripheral blood blast cells, and response to therapy. All patients had high DNA polymerase (α and β) activity which was comparable to that observed in blasts from acute leukemia patients. Twenty patients had low terminal transferase activity of 0.1 to 1.2 units/mg DNA [where 1 unit = 1 nmole Mn2+-deoxyguanosine triphosphate/hr on (dA)12–18 initiator], one had “intermediate” activity of 2.4 units/mg DNA, and three had high activity of 11, 55, and 151 units/mg DNA. Blasts from the last three patients did not have morphological or cytochemical characteristics of lymphoblasts but had, instead, “myeloblastic” morphology and lacked B- and T-cell surface markers and thymus leukemia antigens; one of the patients examined for Greaves' non-T/non-B acute lymphoblastic leukemia antigens was negative. Although the patient with intermediate terminal transferase had a cell population consisting of “myeloblasts” and some cells suggestive of lymphoid origin, such a mixed population was also seen in many of the other 20 patients who had low terminal transferase activity. Moreover, one patient with a majority of lymphoblast-like cells and a hypodiploid karyotype not only had low terminal transferase activity but also did not respond to vincristine-prednisone therapy. Similarly, patients with high terminal transferase activity of 11 and 151 units showed no improvement with vincristine alone or in combination with other drugs, and one with an activity of 55 units did not respond to vincristine-prednisone. These results indicate that high terminal transferase activity or “lymphoid” appearance of cells in blastic phase of chronic myelogenous leukemia should not necessarily be considered as indicators of lymphoblasts or of therapy with agents useful in acute lymphoblastic leukemia.
Symptoms of post-Lyme syndrome in long-term outcome of patients with neuroborreliosis

Sir, ‘Post-Lyme’ syndrome is a term frequently used for symptoms persisting in patients who have experienced Lyme borreliosis (LB). The symptoms usually persist for months to years without responding to repeated antibiotic treatment [1,2]. A prospective study has been performed to optimize PCR diagnostic of neuroborreliosis (NB) during the years 200
[Economic impact of rotavirus vaccination in Panama].

INTRODUCTION Rotavirus (RV) gastroenteritis (GE) causes a significant health and economic burden in Panama. The main objective of this study is to estimate the healthcare costs and the cost-effectiveness of vaccination in Panama from the societal perspective. METHODS An economic model was constructed, using published epidemiological data, country-specific cost estimates, and vaccine efficacy data. The main outcome measures were disease burden, economic burden and the incremental cost-effectiveness ratio (US$/DALY and US$/life saved) of vaccination. RESULTS In Panama, among children during the first five years of life, it is estimated that due to RV GE, 283 per 1,000 have a clinic visit, 24 per 1,000 are hospitalized, and 0.53 per 1,000 die. For every 1,000 children born, RV infection results in US$16,463 in total costs during their first five years of life. An estimated US$862,388 may be spent annually on treatment of outpatient and hospitalized cases in Panama. Vaccination would prevent 65% of the associated deaths, 68% of hospitalizations, 69% of outpatient visits and 65% of associated DALY (Disability Adjusted Life Years). From the societal perspective, RV vaccination produces a cost-effectiveness ratio of US$487 per DALY when the price of the vaccine is US$7.50 per dose. CONCLUSIONS Vaccination can effectively reduce the disease burden and healthcare costs of RV GE in Panama.
Why Do Modern Probabilistic Seismic-Hazard Analyses Often Lead to Increased Hazard Estimates?

The basic elements of probabilistic seismic-hazard analysis (psha) were established almost four decades ago and psha has now become the most widely used approach for estimating seismic-design loads. Although the use of psha is widespread, considerable confusion remains regarding the details of how the calculations should be performed. This situation is largely a result of the way the discipline of psha evolved through a series of articles, reports, and software packages. This article demonstrates that the feature of psha about which there is perhaps the greatest degree of misunderstanding is the treatment of the aleatory variability in ground- motion prediction equations, which exerts a very pronounced influence on the calculated hazard. Probabilistic hazard studies performed in recent years have frequently resulted in appreciably higher design ground motions than had been obtained in previous assessments carried out in the 1970s and 1980s, often sparking controversial debate. Although several factors may contribute to the higher estimates of seismic hazard in modern studies, the main reason for these increases is that in the earlier studies the ground-motion variability was either completely neglected or treated in a way that artificially reduced its influence on the hazard estimates.
Dietas ricas em ácidos graxos poli-insaturados alteram os níveis plasmáticos do testosterona em carneiros?

Este trabalho teve como objetivo avaliar o efeito de dietas com diferentes concentrações de ácidos graxos poli-insaturados complexados com sais de cálcio (AGP-Ca+) sobre os níveis plasmáticos de testosterona em carneiros. Foram utilizados 24 carneiros da raça Santa Inês distribuídos em quatro grupos experimentais que se diferiram na quantidade oferecida de AGP-Ca+ a partir da ingestão de uma dieta base como segue: G3 – grupo controle, sem adição de AGP-Ca+ e com 3% de estrato etéreo (EE), G6, G9 e G12 com a adição de AGP-Ca+ e 6, 9 e 12% de EE, respectivamente. Amostras de sangue dos
Causal inferences regarding prenatal alcohol exposure and childhood externalizing problems.

CONTEXT Existing research on the neurobehavioral consequences of prenatal alcohol exposure (PAE) has not adequately accounted for genetic and environmental confounds. OBJECTIVE To examine the association between PAE and offspring externalizing problems in a large representative sample of families in the United States using measured covariates and a quasi-experimental design to account for unmeasured genetic and environmental confounds. DESIGN This study combines information from the National Longitudinal Survey of Youth and the Children of the National Longitudinal Survey of Youth. The analyses statistically controlled for measured characteristics of the mothers and families and exposure to other prenatal psychoactive substances. In the primary analyses, siblings differentially exposed to prenatal alcohol were compared. SETTING AND PARTICIPANTS Women were recruited from the community using a stratified and clustered probability sample and were followed longitudinally. The sample included 8621 offspring of 4912 mothers. MAIN OUTCOME MEASURES Maternal report of conduct problems (CPs) and attention/impulsivity problems (AIPs) during childhood (ages 4-11 years) using standardized assessments related to psychiatric diagnoses. RESULTS There was an association between PAE and offspring CPs that was independent of confounded genetic and fixed environmental effects and the measured covariates. The CPs in children of mothers who drank daily during pregnancy were 0.35 SD greater than those in children whose mothers never drank during pregnancy. Although AIPs were associated with PAE when comparing unrelated offspring, children whose mothers drank more frequently during pregnancy did not have more AIPs than siblings who were less exposed to alcohol in utero. Additional subsample analyses suggested that maternal polysubstance use during pregnancy may account for the associations between PAE and AIPs. CONCLUSION These results are consistent with PAE exerting an environmentally mediated causal effect on childhood CPs, but the relation between PAE and AIPs is more likely to be caused by other factors correlated with maternal drinking during pregnancy.
Étude et conception d’antennes directives large bande à base de méta-surfaces.

Cette these presente de nouvelles techniques a base de meta-surfaces pour la conception des antennes a gain eleve et a large bande. Dans une premiere contribution, une structure meta-surface a ete utilisee comme plan de masse magnetique. Ce plan magnetique forme un reflecteur semi-cylindrique pour une antenne basique de type dipole. En utilisant une nouvelle technique de compensation de phase, ce reflecteur magnetique permet d’augmenter le gain tout en obtenant un rayonnement sectoriel. Les plans de masse magnetiques planaires ont souvent ete utilises pour les antennes pour augmenter le gain et pour ameliorer la bande d’adaptation, cependant ils n’ont jamais ete utilises pour les antennes cylindriques avec un rayonnement sectoriel. Dans une deuxieme contribution, une nouvelle antenne Fabry-Perot hautement directive a double-bande et avec une bande de gain 3-dB elargie est presentee. L’antenne proposee est composee de deux couches de PRS deposees sur un plan de masse metallique. Le coefficient de reflexion des deux couches PRS combine deux caracteristiques de phase : la double bande et la croissance de phase. La premiere caracteristique permet d’avoir une operation sur deux bandes de frequences : 2.4 GHz et 5.6 GHz, tandis que la deuxieme permet d’augmenter la bande de gain 3-dB. Cette nouvelle antenne offre une solution conjointe de deux problemes traites precedemment d’une maniere separee. Dans une troisieme contribution, une autre antenne Fabry-Perot entierement rigide avec une bande de gain 3-dB elargie est presentee. Pour ce faire, nous avons concu une nouvelle cellule unitaire AMC/PRS a double couche remplie de dielectrique qui vient se poser directement sur le plan de masse metallique de l’antenne excitatrice. La nouvelle cellule possede une reponse de phase de -180 sur une large bande de frequences permettant ainsi la prolongation de la resonance de l’antenne. De cette facon; une bande de gain 3-dB large a pu etre obtenue.
El consentimiento informado en pediatría.

Se hizo una revision bibliografica de los materiales disponibles sobre algunos aspectos generales del consentimiento informado en el contexto de la bioetica, se exponen ademas criterios de autores acerca de su aplicacion en pediatria ya que en este caso el consentimiento es otorgado por los padres quienes habitualmente son los presentantes del paciente. Se analizan las caracteristicas del consentimiento informado y su problematica, se senala la bioetica pediatrica en el acato quirurgico, desacuerdo de los padres frente a acatos terapeuticos determinantes en la vida del infante. Se destaca el consentimiento informado en las investigaciones cientificas, asi como que este es un derecho de todo ser humano y debe ser respetado, en nuestro centro se encuentra en fase de desarrollo pero lejos de corresponderse como nuestro.
Effect of supplemental pig milk replacer on litter performance: seasonal variation in response.

The objective of this study was to determine the effect of supplemental milk replacer on sow and litter performance. The study was conducted in 12 farrowing groups (171 litters) over a 3.5-yr period (October 1990 to April 1994). Commercial milk replacer was prepared fresh daily (150 g/L) and offered with ad libitum access in the farrowing crates within 24 h of parturition and was continued through weaning (d 21). Average pig weight (control, 5.5 kg/pig; supplemented, 6.4 kg/pig; P < .001) and total litter weight (control, 52.2 kg/litter; supplemented, 60.9 kg/litter; P < .001) at weaning were greater for litters receiving supplemental milk replacer. There was no effect (P > .2) of supplemental milk replacer on feed intake, backfat thickness, or body weight loss in the sow. Consumption of milk replacer varied greatly among litters. A portion of this variation in intake was accounted for by differences in ambient temperature among farrowing groups. Average milk replacer intakes (liters per pig) from birth to d 21 were 2.5 L/pig (.375 kg dry matter) and 9.9 L/pig (1.49 kg dry matter) for pigs born during the cool and warm seasons, respectively (P < .001). The weaning weight advantage conferred by milk replacer was most evident during the warmer months. Sow feed intakes averaged 5.8 and 3.9 kg/d over the same periods (P < .001). These results demonstrate the advantage of milk replacer on weaning weight and indicate that the greatest benefit from the supplement is during the warmer months when sow feed intake and subsequent milk production are lower.
Bogoliubov modes of a dipolar condensate in a cylindrical trap (13 pages)

The calculation of properties of Bose-Einstein condensates with dipolar interactions has proven a computationally intensive problem due to the long range nature of the interactions, limiting the scope of applications. In particular, the lowest lying Bogoliubov excitations in three-dimensional harmonic trap with cylindrical symmetry were so far computed in an indirect way, by Fourier analysis of time-dependent perturbations, or by approximate variational methods. We have developed a very fast and accurate numerical algorithm based on the Hankel transform for calculating properties of dipolar Bose-Einstein condensates in cylindrically symmetric traps. As an application, we are able to compute many excitation modes by directly solving the Bogoliubov-De Gennes equations. We explore the behavior of the excited modes in different trap geometries. We use these results to calculate the quantum depletion of the condensate by a combination of a computation of the exact modes and the use of a local density approximation.
Evaluation of the indirect fluorescent antibody test and modified agglutination test for detection of antibodies against Toxoplasma gondii in experimentally infected pigs

The study determined the sensitivity and specificity of the indirect fluorescent antibody test (IFAT) and modified agglutination test (MAT) for anti-Toxoplasma gondii antibody detection by analyzing sera from 46 experimentally infected pigs. Values for sensitivity were 95.7% (confidence interval 95%: 84.0-99.2%) and for specificity 97.8% (confidence interval 95%: 87.0-99.9%) in both tests. There was an optimum agreement of results between IFAT and MAT evidenced by a Kappa test of 0.86. These results validate these tests for the detection of T. gondii infection in pigs. IFAT and MAT despite methodologies with different characteristics and readings have similar accuracy in pig serum samples.
De la classification moléculaire des gliomes à une nouvelle stratégie thérapeutique de réactivation des macrophages au sein de la tumeur

Les tumeurs sont tres heterogenes a la fois au niveau moleculaire et au niveau de la diversite cellulaire composant leur microenvironnement. La classification des gliomes repose actuellement sur des criteres histologiques qui sont enclins a de fortes subjectivites inter- et intra-observateurs. Le but de ce projet est de realiser une classification moleculaire des gliomes de haut grade en se basant sur des donnees proteiques permettant de localiser des biomarqueurs potentiels directement sur le tissu. Des sous-regions ayant des profils moleculaires differents ont ete mises en evidence et les molecules les composants ont ete identifiees. Les resultats demontrent que les annotations histologiques ne concordent pas avec la classification moleculaire. Cette heterogeneite est egalement retrouvee dans le microenvironnement des tumeurs ou l’on retrouve des cellules immunitaires telles que les macrophages. Les macrophages sont detournes de leur fonction par la tumeur pour lui permettre de se developper. Une strategie therapeutique pour contrer sa croissance est de reorienter le phenotype des macrophages vers un phenotype antitumoral. L’inhibition de la proproteine convertase 1/3 s’est revelee etre une strategie prometteuse pour la reactivation des macrophages via les recepteurs TLR. Les facteurs secretes par ces macrophages ont un effet sur la viabilite et l’invasion de differentes cellules cancereuses en fonction des ligands des recepteurs TLR utilises. La premiere partie nous a permis d’identifier des sous-groupes de gliomes qui en fonction de leur profil moleculaire pourront recevoir des traitements personnalises bases, par exemple, sur l’inhibition de proproteines convertases.
A NETwork COding based Multicasting (NETCOM) over IEEE 802.11 Multi-hop

In this paper, we present an analysis of various multicast schemes over IEEE 802.11 multi-hop. Analyzing performance of wireless multicasting communication is important because multicast communication is gaining more and more attention in wireless networks with numerous potential applications. The network coding has recently drawn people's attention and has proven to have benefits when it is applied to multicasting. Multi-hop wireless communication has been extensively investigated as a candidate of next generation wireless communication. When the network coding is used in multi-hop wireless network, we can expect network throughput to be enhanced. Because network coding is in theoretical stage, its performance in existing wireless communication system is not yet fully investigated. We used IEEE 802.11 MAC to apply various multicasting schemes including network coding and presented their performance.
Intensive Dryland Agriculture in Kaupō, Maui, Hawaiian Islands

The late pre-contact political economies of Hawai'i and Maui Islands were supported in large part by intensified dryland field systems, focused on the cultivation of sweet potatoes. Three such systems have been well documented for Hawai'i Island, and one for Moloka'i Island, but none previously for Maui. We report here the results of remote sensing and GIS analysis, combined with ground survey, of such an intensive field system in Kaupō District, Maui. The field system is archaeologically manifested by a closely spaced grid of east-west trending embankments, delineating small field plots, bisected at right angles by longer north-south trending walls, which primarily appear to be territorial divisions. A range of smaller features such as enclosures, shelters, and platforms are found within the field system area indicating the presence of a complex social community integrated within the system. In aggregate the field system covered between 12.5 and 15 km2, and could readily have supported a population of 8000-10,000 persons. Hawaiian oral traditions indicate that Maui king Kekaulike made Kaupō his seat in the early eighteenth century. Two large temples, Lo'alo'a and Kou, are situated at the east and west extremes of the field system, and further indicate the significance of this highly productive landscape.
Enhanced ectodysplasin‐A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form

Hair morphology differs dramatically between human populations: people of East Asian ancestry typically have a coarse hair texture, with individual fibers being straight, of large diameter, and cylindrical when compared to hair of European or African origin. Ectodysplasin‐A receptor (EDAR) is a cell surface receptor of the tumor necrosis factor receptor (TNFR) family involved in the development of hair follicles, teeth, and sweat glands. Analyses of genome‐wide polymorphism data from multiple human populations suggest that EDAR experienced strong positive selection in East Asians. It is likely that a nonsynonymous SNP in EDAR, rs3827760, was the direct target of selection as the derived p.Val370Ala variant is seen at high frequencies in populations of East Asian and Native American origin but is essentially absent from European and African populations. Here we demonstrate that the derived EDAR370A common in East Asia has a more potent signaling output than the ancestral EDAR370 V in vitro. We show that elevation of Edar activity in transgenic mice converts their hair phenotype to the typical East Asian morphology. The coat texture becomes coarse, with straightening and thickening of individual hairs and conversion of fiber cross‐sectional profile to a circular form. These thick hair fibers are produced by enlarged hair follicles, which in turn develop from enlarged embryonic organ primordia. This work shows that the multiple differences in hair form between East Asian and other human populations can be explained by the simplest of genetic alterations. Hum Mutat 0, 1–7, 2008. © 2008 Wiley‐Liss, Inc.
Temperature Dependent Dielectric Absorption of MIM Capacitors: RF Characterization and Modeling

This paper presents dielectric absorption measurements of a MIM capacitor between 100Hz and 10GHz over a broad temperature range. The activation energy of the dielectric absorption is extracted and a new model, taking the temperature dependency of the dielectric absorption into account, is presented. Finally the impact of the temperature dependent dielectric absorption on the MIM capacitors RF performance and MIM capacitor based circuit simulation is discussed
The Diagnosis and Management of Dry Eye: A Twenty-five–Year Review

Purpose. To review the advances in the diagnosis, pathogenesis, and management of dry eye disease in the past 25 years. Methods. Literature review. Results. The preocular tear film is a hydrated mucus gel that contains soluble antimicrobial proteins and growth factors that protect and support the ocular surface. The final common pathway in dry eye is a perturbation of the integrated ocular surface/lacrimal gland reflex unit. Diagnostic tests evaluating tear composition and clearance appear to show stronger correlation with the severity of ocular irritation symptoms and keratoconjunctivitis sicca (KCS) than the conventional Schirmer tests. KCS is a condition of abnormal differentiation and mucus production by the ocular surface epithelium that results in a poorly lubricated, abnormally permeable ocular surface that has increased susceptibility to environmental insults. Chronic subclinical ocular surface inflammation appears to play a key role in the pathogenesis of KCS. New therapeutic strategies are aimed at reducing the ocular surface inflammation of dry eye disease. Conclusions. There has been a tremendous increase in knowledge regarding dry eye disease in the past 25 years that has resulted in improved diagnostic classification and new targeted therapies.
Implementación de una interfaz de visualización de datos eficiente e interactiva a partir de una perspectiva geométrica

El uso de metodos de mineria de datos y tecnicas de visualizacion de datos por separado conlleva a la necesidad de expertos para la interpretacion de resultados, esto es algo negativo porque involucra un incremento en tiempo, costos y trabajo para llegar a la etapa ultima del procesamiento de datos, la cual es determinar la informacion util inmersa en los datos analizados. La integracion de los metodos de mineria y las tecnicas de visualizacion es una necesidad latente; aunque existen herramientas que realizan dicha integracion, el diseno de un sistema de analisis visual que se adapte adecuadamente a las necesidades y requerimientos de un usuario particular es aun un problema abierto. Una de las formas de hacer una visualizacion inteligible de grandes volumenes de datos es reducir la dimension de los mismos de tal forma que se obtengan representaciones facilmente interpretables por el ser humano. En esta tesis se propone implementar una interfaz de usuario de facil manejo que permita una interaccion con los resultados de la representacion de los datos realizando una mezcla de metodos de reduccion de dimension. Para este fin, se propone un modelo que realice dicha mezcla a traves de un enfoque geometrico, mediante el cual un usuario –no necesariamente experto– intuitivamente manipule dinamicamente la representacion visual de los datos usando los parametros de un poligono geometrico.