Miracle-dz/UniFAR-FTUs huggingface dataset:
Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor.

DOV 216,303 [(+/-)-1-(3,4-dichlorophenyl)-3-azabicyclo-[3.1. 0]hexane hydrochloride] is the prototype of a class of compounds referred to as "triple" reuptake inhibitors. Such compounds inhibit the reuptake of norepinephrine (NE), serotonin (5-HT), and dopamine (DA), the three neurotransmitters most closely linked to major depressive disorder. DOV 216,303 inhibits [(3)H]NE, [(3)H]5-HT, and [(3)H]DA uptake to the corresponding human recombinant transporters (expressed in HEK 293 cells) with IC(50) values of approximately 20, 14, and 78 nM, respectively. DOV 216,303 is active in tests predictive of antidepressant activity including the mouse forced swim test and reversal of tetrabenazine-induced ptosis and locomotor depression. The pharmacodynamic, pharmacokinetic, and toxicological profile of DOV 216,303 in animals prompted us to initiate clinical studies. In both single and multiple dose studies using normal volunteers, DOV 216,303 was safe and well-tolerated. Furthermore, both C(max) and AUC values were dose-proportional between 5-150 mg. The plasma concentrations of DOV 216,303 at doses >10 mg were in excess of the IC(50) values for inhibition of biogenic amine reuptake. In a Phase II study designed to explore the safety and tolerability of DOV 216,303 in depressed individuals, patients received either 100 mg DOV 216,303 (50 mg b.i.d.) or 40 mg citalopram (20 mg, b.i.d.) for two weeks. A placebo arm was not employed in this study because several institutional review boards required administration of an active control to severely depressed individuals. Time dependent reductions in HAM-D scores (the primary outcome measure) were observed in both the DOV 216,303 and citalopram groups compared to baseline scores (p < 0.0001). The side effect profile was not remarkably different between treatment arms. These findings provide preliminary evidence of a clinically meaningful antidepressant action with a molecule capable of inhibiting the three transmitters most closely linked to major depressive disorder.
Parallel computing for mining Frequent Itemset

Frequent Itemset [1] mining is a key step in association rule problem. Early classical algorithms are serial algorithms, such as the Apriori [2], and FP-growth [3]. With the rapid development of information technology, today, the amount of data often needed to handle is based on GB or TB, which has forced the efficiency of mining algorithms significantly improved. At present, more effective method is to use parallel computing to improve efficiency. In this regard, we propose a method based on partition of computing tasks to achieve parallel mining of frequent pattern, and has been experimentally verified in PC cluster.
Risk Factors for Acute Lung Injury After Thoracic Surgery for Lung Cancer

Acute lung injury (ALI) may complicate thoracic surgery and is a major contributor to postoperative mortality. We analyzed risk factors for ALI in a cohort of 879 consecutive patients who underwent pulmonary resections for non-small cell lung carcinoma. Clinical, anesthetic, surgical, radiological, biochemical, and histopathologic data were prospectively collected. The total incidence of ALI was 4.2% (n = 37). In 10 cases, intercurrent complications (bronchopneumonia, n = 5; bronchopulmonary fistula, n = 2; gastric aspiration, n = 2; thromboembolism, n = 1) triggered the onset of ALI 3 to 12 days after surgery, and this was associated with a 60% mortality rate (secondary ALI). In the remaining 27 patients, no clinical adverse event preceded the development of ALI—0 to 3 days after surgery—that was associated with a 26% mortality rate (primary ALI). Four independent risk factors for primary ALI were identified: high intraoperative ventilatory pressure index (odds ratio, 3.5; 95% confidence interval, 1.7–8.4), excessive fluid infusion (odds ratio, 2.9; 95% confidence interval, 1.9–7.4), pneumonectomy (odds ratio, 2.8; 95% confidence interval, 1.4–6.3), and preoperative alcohol abuse (odds ratio, 1.9; 95% confidence interval, 1.1–4.6). In conclusion, we describe two clinical forms of postthoracotomy ALI: 1) delayed-onset ALI triggered by intercurrent complications and 2) an early form of ALI amenable to risk-reducing strategies, including preoperative alcohol abstinence, lung-protective ventilatory modes, and limited fluid intake.
Saccade direction encoding in the primate entorhinal cortex during visual exploration

Significance Characterizing the dynamic encoding of body orientation and eye movements in the brain is central to understanding spatial representation. Studies in rodents have revealed an allocentric heading representation system known as the head-direction network. Visual information is presumed to be critical to rodent head-direction encoding; however, differences in the primate and rodent visual systems along with differences in exploratory behaviors across species have made it difficult to directly extend the findings from rodents to primates. This study describes a previously unidentified functional cell type in the primate entorhinal cortex that shows selectivity for the direction of saccadic eye movements. Future research avenues critical to increasing our understanding of spatial representation in the brain are suggested. We recently demonstrated that position in visual space is represented by grid cells in the primate entorhinal cortex (EC), suggesting that visual exploration of complex scenes in primates may employ signaling mechanisms similar to those used during exploration of physical space via movement in rodents. Here, we describe a group of saccade direction (SD) cells that encode eye movement information in the monkey EC during free-viewing of complex images. Significant saccade direction encoding was found in 20% of the cells recorded in the posterior EC. SD cells were generally broadly tuned and two largely separate populations of SD cells encoded future and previous saccade direction. Some properties of these cells resemble those of head-direction cells in rodent EC, suggesting that the same neural circuitry may be capable of performing homologous spatial computations under different exploratory contexts.
Obstakels voor hergebruik van kwalitatieve data

Interviews spelen zowel in kwantitatief als in kwalitatief onderzoek een belangrijke rol als methode van dataverzameling. Bij kwantitatief onderzoek gaat het meestal om sterk gestandaardiseerde vragenlijsten waarin gesloten vragen domineren. Kenmerkend voor de verschillende vormen van kwalitatief onderzoek zijn open interviews waarin de geinterviewden alle ruimte krijgen om in hun eigen woorden hun verhaal te houden en antwoorden te formuleren. Om die ruimte te creeren zijn de vragenlijsten ook zelden volledig gestandaardiseerd. De interviewer kan zo nodig de vraagvolgorde en eventueel de vraagformuleringen aanpassen, en vervolgvragen inlassen om door te vragen op datgene wat de geinterviewde vertelt. Kwalitatieve interviews kunnen – mits de interviewkwaliteit van voldoende niveau is – onderzoeksdata opleveren die buitengewoon ‘rijk’ zijn aan informatie. Dat geldt zowel voor biografische interviews en diepte-interviews over bepaalde thema’s als voor informanteninterviews of expertinterviews. De voor kwalitatief onderzoek kenmerkende ‘rijkdom’ van verzamelde data leent zich daarom vrijwel altijd voor meerdere onderzoeksdoelen. Maar vreemd genoeg zijn hergebruik en secundaire analyse van onderzoeksdata in de wereld van kwalitatief onderzoek een vrijwel onbekend fenomeen. Gebruikelijk is dat een kwalitatieve onderzoeker zelf zijn/haar eigen data verzamelt, analyseert ten behoeve van een specifiek onderzoeksdoel en na afloop van het onderzoek voorgoed opbergt. Dat is pure onderbenutting wanneer men zich realiseert dat veldwerkkosten van kwalitatief onderzoek in het algemeen aanzienlijk zijn. Waarom maakt niemand in de kwalitatieve onderzoekswereld zich hier druk om? Hoe komt het dat een onderzoekspraktijk waarin grootscheepse kapitaalvernietiging tot de ‘normale’ gang van zaken behoort, nauwelijks ter discussie gesteld wordt? Wat zijn precies de obstakels die hergebruik van kwalitatieve data om methodologische of andere redenen belemmeren? Die vragen vormen de aanleiding voor deze debatbijdrage. Voorafgaand aan de beantwoording daarvan zal ik eerst ingaan op mogelijkheden van hergebruik van kwalitatieve data.
Virusni turizam: virus dengue

181 Pregledni ~lanak Denga je akutna infektivna bolest karakterizirana vru}icom, glavoboljom, osipom i mijalgijama, a uzrokovana je jednim od ~etiri razli~ita virusa roda Flavivirusa. Dva glavna vektora za viruse denge su komarci: Aedes aegypti i Aedes albopictus. Denga je postala jedna od najva`nijih emergentnih bolesti koja predstavlja problem me|u putnicima. Zadnjih godina Hrvatska je postala poznata i presti`na turisti~ka destinacija sa sve vi{e i vi{e turista svake godine, osobito tijekom ljeta. Hrvatska nije endemsko podru~je za viruse dengue. Me|utim, nedavno otkrivena prisutnost (2004. g) Ae. albopictus u Hrvatskoj, kao i dva importirana slu~aja denge u 2007. god. , predstavljaju zna~ajno upozorenje djelatnicima u javnom zdravstvu kao i ostalim medicinskim stru~njacima.
Evaluation of an ELISA to detect antibodies to maedi-visna virus in individual and pooled samples of milk from sheep

An ELISA was used to detect antibodies to maedi-visna virus in samples of serum and milk from individual sheep; the results obtained indicated that the ELISA can be used to detect antibodies in milk. The assay was also applied to samples of bulk-tank milk; a standard curve was created and used to calculate the seroprevalence of maedi-visna in 11 flocks of sheep and the results were compared with the results obtained by applying the ELISA to individual serum samples. There was good agreement between the seroprevalences calculated from the standard curve for bulk-tank milk and from the individual serum samples.
« L'entraide des élèves du secondaire pendant les cours d'éducation physique »

Les auteurs decrivent comment des eleves du secondaire s’entraident spontanement pendant les cours d’education physique. Un questionnaire, inspire de la technique des incidents critiques, a ete ulilise pour recueillir les donnees. Une strategie d’analyse inductive des recits d’une experience d’entraide vecue par 500 eleves a permis d’identifier des types d’activites plus ou moins propices a l’entraide et de decrire l’interaction entre les etudiants en termes de strategies d’aide et de types de reactions a l’aide recue ou apportee.
Rapid spread of male‐killing Wolbachia in the butterfly Hypolimnas bolina

Reproductive parasites such as Wolbachia can spread through uninfected host populations by increasing the relative fitness of the infected maternal lineage. However, empirical estimates of how fast this process occurs are limited. Here we use nucleotide sequences of male‐killing Wolbachia bacteria and co‐inherited mitochondria to address this issue in the island butterfly Hypolimnas bolina. We show that infected specimens scattered throughout the species range harbour the same Wolbachia and mitochondrial DNA as inferred from 6337 bp of the bacterial genome and 2985 bp of the mitochondrial genome, suggesting this strain of Wolbachia has spread across the South Pacific Islands at most 3000 years ago, and probably much more recently.
Load Signature Formulation for Non-Intrusive Load Monitoring Based on Current Measurements

In this paper we present a new methodology for the formulation of efficient load signatures towards the implementation of a near-real time Non-Intrusive Load Monitoring (NILM) approach. The purpose of this work relies on defining representative current values regarding the 1st, 3rd and 5th harmonic orders to be utilized in the load signatures formulation. A measurement setup has been developed and steady-state measurements have been performed in a Low Voltage residence. A data processing methodology is proposed aiming to depict representative current values for each harmonic order in order to keep the load signature short and simple. In addition, a simple disaggregation scheme is proposed under linear equations for the disaggregation mode in order to examine the near-real time application of the methodology. The analysis indicates that the developed load signatures could be efficient for a per second application rate of the NILM algorithm. The results show that the higher harmonic currents facilitate the identification performance. Finally, the analysis concludes that for combinations that include appliances with intense harmonic content, the phase angle of the higher for harmonic currents should also be considered to the load signatures formulation.
AISeL ) All Sprouts Content Sprouts 4-11-2008 Factors Inhibiting Information Process Integration

Although researchers have considered process integration in some detail, describing it using expressions such as tight coordination among activities, standardization and tight coupling, operating as a whole, etc., we lack an operational measure. Aubert, Vandenbosch and Mignerat (2003) proposed a formal definition of process integration as the sum of efforts expended by the receiving activities of a process to achieve access, transparency, granularity and timeliness of goods and data, relative to the total value added by the process. In other words, the fewer steps and handoffs and the smaller the physical distance in a process, the greater its integration. To test their proposal, we undertook 42 on-site interviews to understand the degree of integration of ten information processes in four industries. We found that the four properties are collectively exhaustive, but fail the test of mutual exclusivity. In order to differentiate among them, it is necessary to uncover instances of information transformation (granularity and transparency) before looking for needless information transfer (accessibility and timeliness). The degree of integration of the ten processes ranged from 9 percent to 81 percent. Accessibility was the most common reason for a lack of process integration and re-keying known data was the major activity undertaken to make information more accessible. A great deal of the re-keying was for documentation purposes. More research is necessary to understand the purpose and value of documentation vis-à-vis the real work accomplished in information processes.
In vitro rooting of tenera hybrid oil... In vitro ROOTING OF TENERA HYBRID OIL PALM (Elaeis guineensis Jacq.) PLANTS

1 Received on 16.06. 2016 accepted for publication on 12.09. 2017. 2 Universidade Federal de Lavras, Doutoranda em Biotecnologia Vegetal, Lavras, Minas Gerais Brasil. E-mail: <marluciabio@yahoo.com. br>. 3 Universidade Federal de Lavras, Graduanda em Agronomia, Lavras, Minas Gerais Brasil. E-mail: <raissa_silveira93@hotmail.com>. 4 Universidade Federal de Lavras, Departamento de Química, Lavras, Minas Gerais Brasil. E-mail: <luciano@dqi.ufla. br>. 5 Universidade Federal de São João Del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, Minas Gerais Brasil. E-mail: <vanessastein@ufsj.edu. br>. 6 Universidade Federal da Paraíba, Departamento de Biologia Celular e Molecular, João Pessoa, Paraíba Brasil. E-mail: <lucoutsilva@yahoo.com. br>. *Corresponding author.
A Principal-Agent Analysis of Accountability in Public Procurement

The principal-agent problem has done much in recent years to illuminate diverse legal subjects, such as the managementshareholder relationship in corporations, real-estate markets, insurance, employment, and other real-life situations (Harris & Raviv, 1978; Jensen & Meckling, 1976; Ross, 1973). In a principal-agent relationship, one party – the agent – is required to perform some service on the behalf of the other party – the principal, who involves the delegation of some discretion and decision-making authority. The problem highlighted by the agency model is that often there will be a divergence between the actual decisions made by agents and the decisions that would maximize the principal’s benefits. This divergence arises because, when making a decision, agents also seek to maximize their own self-interest. Therefore, whenever the agent's actions are for the sole benefit of the principal (and thus contribute nothing for promoting the agent's self-interest), he/she will engage in a lower level of effort instead of a high level.
Quick recovery of leaf photosynthesis and fruit quality from soil water deficit of Citrus aurantiifolia growing in a city.

Under the projected warming climate, water scarcity will become one of the main challenges for growing crops. Such issue is particularly difficult in urban environments where growing conditions for plants are limited and warming effect is intensified. Here, we showed that infrequent irrigation may be performed when growing lime (Citrus aurantiifolia) saplings in Bangkok, Thailand, with quick recovery of photosynthesis and fruit quality. During a two-week water-deficit experiment, stomatal conductance of the lime saplings decreased up to 67% when soil moisture declined by 40% from the control level on day 6, resulting in 27% and 16% reductions of net photosynthesis (Anet) and transpiration (E), respectively. Accordingly, water-use efficiency decreased by 20%. After that, irrigation was resumed to study the recovery effect on the gas exchange parameters. Results showed full recovery after 3 days with Anet, E and WUE values not statistically different from those in the control group. Lime fruits were harvested for analysis of vitamin C content. We found that, after the water deficit and re-watering, vitamin C content in the lime fruits was not affected, showing similar values across treatments. Our results suggested that discontinuous irrigation (i.e. up to 6 days of withheld irrigation) may be applied to induce moderate soil water deficit (-40% of the control level) when growing the lime saplings in a raised-bed plot in the city, The international journal by the Thai Society of Higher Education Institutes on Environment EnvironmentAsia
Recommendations in Travel

Recommender systems have received much attention in recent years, and they have been successfully applied in many different domains. With each domain come new constraints that require system designers to make choices about how to apply and extend generic algorithms in their context. Booking.com is planet earth's number one accommodation reservation site. The accommodation recommendation problem that it needs to solve has several interesting and unique challenges that make that a straightforward matrix factorization or a basic bi-linear model are not sufficient to provide the required predictions. In this talk, we will discuss several of the challenges we have encountered and solutions we have developed.
Data mining parasite genomes

The term ‘data mining’ can be used to describe any process where useful information is extracted from data with a large background of ‘noise’. In the context of a genome project, several stages involve data mining. Amongst the sequence data, ‘signals’ need to be detected that indicate the presence of interesting features. Often this involves differentiating between transcribed and non-transcribed bases to predict coding regions. After detection, defining the roles of these sequences involves sifting through multiple lines of evidence. If these roles are accurately reflected in genome annotation, they can be used by researchers to frame queries and interrogate the data further.
ANALYSIS OF NUTRITIONAL LABEL USE ON PACKAGED FOODS AMONG URBAN HOMEMAKERS IN OGUN STATE, NIGERIA

This paper presents the type of food label information used by homemakers in Abeokuta while pur- chasing packaged foods and the socio-economic characteristics influencing its usage. Structured questionnaire was use to elicit information from 149 homemakers drawn by multi-stage sampling tech- niques. The study found that majority (87.20%) of the homemakers were females with mean age of 40.2 years. About two-third (65.40%) of the homemakers considered information on food labels before purchasing packaged foods. The most commonly considered food label information was found to be the NAFDAC (National Agency for Food and Drug Administration and Control) number (63.8%), fol- lowed by the expiry date (59.1 %), brand name (57%), country of manufacture (51.7%) and nutritional facts (51.0%). Results from logit regression models showed that sex, education, marital status, occu- pation, income and health status were the key factors that significantly (p<0.05) influenced nutritional label use.
[Opto-Electron Eng, 2019, 46(3)] A review of photopolymers on holography volume data storage

Volume holographic storage technology has the advantages of high storage density, huge data capacity, parallel read and write, fast transmission speed and so forth. In Big Data era, this method has great potential to meet its needs of low cost and low storage density. Holographic storage devices fabricated by photopolymer materials have attracted wide attention because of its several advantages, such as low cost, light weight, and high commercial value. The excellent performance of photopolymer applied on volume holographic storage is introduced in this paper.
Chromosome Engineering Techniques Modify Contents and Constituents of Fructans in Cultivated Allium Species

Onion (Allium cepa L.) and shallot (A. cepa Aggregatum group) exhibit wide variation in bulb fructan content and the Frc locus on chromosome 8 conditions much of this variation. To understand the biochemical basis of Frc we conducted biochemical and genetic analyses of Allium fistulosum (FF) shallot alien monosomic addition lines (AALs; FF+1A-FF+8A), onion mapping populations and shallot A. fistulosum addition lines. Sucrose and fructan levels in leaves of FF+2A were significantly lower than FF throughout the year. FF+8A showed significantly higher winter sucrose accumulation and sucrose phosphate synthase (SPS) activity. Markers for additional candidate genes for sucrose metabolism were obtained by cloning a major SPS expressed in onion leaf and exhaustively mining onion EST resources. SPS and sucrose synthase (SuSy) loci were assigned to chromosome 8 and 6 respectively using AALs and linkage mapping. Further loci were assigned, using AALs, to chromosomes 1 (sucrose phosphate phosphatase), 2 (SuSy and 3 invertases) and 8 (neutral invertase). The shallot A. fistulosum AAL (AA+8F) also showed the high fructan accumulation. The concordance between chromosome 8 localization of SPS and elevated leaf sucrose levels conditioned by high fructan alleles at the Frc locus in bulb onion or alien monosomic additions of chromosome 8 in A. fistulosum and in A. cepa suggest that the Frc locus may condition variation in SPS activity. _____________________________________________________________________________________________________________
UvA-DARE ( Digital Academic Repository ) The efficiency of education in generating literacy : a stochastic frontier approach

The growing importance attached to education as a key factor to improve economic performance coupled with the persistent scarcity of resources for education makes it important that skills and literacy are produced efficiently. This paper provides an international comparison of the efficiency of literacy production. We find substantial differences between countries in levels of literacy, differences in literacy between education levels and differences in the efficiency of literacy production. The findings suggest that in almost all countries the scope for efficiency improvements in education is large. So even without major increases in (public) funding, improvements in educational outcomes are achievable. We can get better value for the money we spend on education. JEL Classifications: I22, C14