Miracle-dz/UniFAR-FTUs huggingface dataset:
Entrepreneurial Orientation and Innovation Performance: The Mediating Role of Knowledge Management

Firms with greater innovativeness will be more successful in responding to changing environments and in developing new capabilities that allow them to achieve better performance. Former researchers have emphasized that Entrepreneurial Orientation (EO) is a key ingredient for firm innovation. This study tried to accentuate the role of Knowledge Management (KM) in the relations of Entrepreneurial Orientation (EO) and innovation performance. The population in the study was 164 Iranian SMEs. This study developed and simultaneously tested three hypotheses about: (1) The impact of EO on innovation performance, (2) The impact of EO on KM, and (3) The impact of km on innovation performance. LISREL software was used to test the hypotheses. The results indicated that entrepreneurial orientation both directly (B = 0.38) and indirectly through the knowledge management (B = 0.377) affected innovation performance. Hence, knowledge management acts as a mediator between entrepreneurial orientation and innovation performance.
Drug Informatics from Evolution to the Present Outlook

Informatics is the science of information and the blending of people, biomedicine and technology. Medical informatics as a discipline is still young, in particular when compared to other medical disciplines. The American Medical Informatics Association defined medical informatics as "all aspects of understanding and promoting the effective organization, analysis, management, and use of information in health care". Drug informatics emphasizes the use of technology as an integral tool in effectively organizing, analyzing, and managing information on medication use in patients. Drug Informatics is a specialty area within the realm of clinical pharmacy that has evolved as technology and clinical practice have changed. The objective of this review is to make the reader familiar with the term, informatics, medical informatics and drug information; to describe the evolution of the informatics world; to describe the purpose, requirements and functions of drug information center (DIC). Effective drug information and evaluation skills are a vital part of routine pharmacy practice. Drug information specialists are trained individuals who have clinical knowledge and skills that allow them to provide clear, concise, and accurate recommendations regarding drug use. DIC is a unit designed for receiving, collecting, analyzing, and providing unbiased, accurate and up-to-date information about drugs and their use. Drug information Service (DIS) is the activities function and projects through which the DICs achieve their objectives and which constitute their programs of work. The Purposes of DIC include provision of comprehensive, meaningful and well evaluated information on drugs with a view to enhancing the rational use of drugs; disseminate technical, scientific & objective information to health care providers; disseminate appropriate drug information to the general public; generate, collect, analyze and maintain drug information data; design produce and distribute drug information materials and give appropriate information on toxicology and poisoning. In conclusion, even though the discipline is still young and expected to be stronger in the future, the involvement of pharmacist as a drug information provider has been limited to specific areas of activities. Therefore, it is on the shoulder of the pharmacist to act appropriately and to change the outlook of the activities in near future.
TOWARDS PRACTICAL APPLICATION OF SWARM ROBOTICS: OVERVIEW OF SWARM TASKS

Swarm robotics is a relatively new research area inspired from biological systems such as ant or bee colonies. It composes a system consisting of many small robots with simple control mechanisms capable of achieving complex collective behaviours on the swarm level such as aggregation, pattern formation and collective transportation to name a few. However, more research is still required to apply swarm robotics in practice. Within the scope of our knowledge at the moment there are no swarm robotics applications for real-life problems. The current research tends to solve specific tasks in controlled laboratory environments. In this paper we survey the existing works on swarm robotics and their applications and also analyse the potential of their applicability to solve real-life problems The analysis of the results of these studies shows that robot swarms are capable to solve these tasks satisfactory in controlled laboratory environments, at the same time there is no evidence of applying swarm robotics to solve real-life problems. The purpose of this paper is to take a step closer to bridging the gap between research in swarm robotics and their practical applications. We analyze the existing approaches in the field of swarm robotics and discuss their result applicability for solving real-life problems by outlining tasks that have been studied in the context of swarm robotics systems and analysing their potential practical applications. We also discuss how the tasks could be combined to achieve desirable practical results. Tasks of the swarm The potential applications of swarm robotics range from surveillance operations (15) to mine disarming in hostile environments (16). We believe it is essential to identify the tasks that can be solved using swarm robotics. According to recent literature reviews (1; 2; 17-19), swarm robotics has been studied in the context of the following tasks: Aggregation deals with spatially grouping all robots together in a region of the environment. Aggregation is used to get robots in a swarm sufficiently close together and can be used as a starting point for performing some additional tasks, such as communication with limited range. Aggregation near points of interest can be viewed as the first step of more complex tasks, such as collective
Credit Cardholder: Convenience User or Credit Revolver?

The credit card is a double-edged sword. Credit facilities offered by a credit card, which provide liquidity for unforeseen circumsfances, can also tempt its holder to overspend. This paper investigates the factors that distinguish a cardholder who uses the credit card as a convenient payment tool from a cardholder who uses the credit card as a credit instrument. It is found that socio-economic variables are significant in profiling the type of credit card user. Credit education is also found to be important in shaping a responsible usage of credit cards.
Genome-wide bioinformatics analysis reveals CTCFL is upregulated in high-grade epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy that threatens the health of females. Previous studies have demonstrated that the survival outcomes of patients with different EOC grades varied. Therefore, the EOC grade is considered to serve as a distinctive prognostic factor. To date, the evaluation of ovarian cancer grade relies on pathological examination and a quantitative index for diagnosis is lacking. Furthermore, the dysregulation of genes has been demonstrated to exert pivotal functions in the carcinogenesis of EOCs. Therefore, the identification of effective biomarkers associated with EOC grade is of importance for the development of therapeutic regimens, and also contributes to the prediction of EOC prognosis. Microarrays have been increasingly applied for the identification of potential molecular biomarkers for numerous diseases including EOC. In the present study, four public microarray datasets (GSE26193, GSE63885, GSE30161 and GSE9891) were analyzed. A total of 6,103 upregulated probes corresponding to 5,766 genes, and 4,004 downregulated probes corresponding to 3,707 genes were identified in the GSE26193, GSE63885 and GSE30161 datasets. ALK and LTK ligand 2 was the most downregulated gene associated with the tumor grade, while CCCTC-binding factor like (CTCFL), EGF like domain multiple 6, radical S-adenosyl methionine domain containing 2 and SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 were the most upregulated genes associated with EOC grade. The GSE9891 dataset was added for further analysis. Only one probe (1552368_at) encoding for CTCFL was identified to be consistently upregulated in the four examined datasets. Immunohistochemical analysis was used to detect the expression of CTCFL between low- and high-grade EOC tissues and revealed that the EOC grade was closely associated with CTCFL level. This was corroborated via the reverse transcription-quantitative polymerase chain reaction. Taken together, the results of the present study suggested that CTCFL is upregulated in high-grade epithelial ovarian cancer.
Investigation of Play-Wear Damage on Steel Music Strings Using Atomic Force Microscope and Low Level Resistance Method

The strings of stringed musical instruments are subject to both reciprocating sliding wear due to contact with the player’s fingers and repetitive impact with a plectrum, therefore, they gradually lose their brilliance and responsiveness. Nevertheless, there has been almost no scientific investigation about the effects of play-wear on music strings and its determination. In this study, the investigation of play-wear on the strings of C1085 steel wire was performed using the lute-like Baglama stringed instrument. The wear loss of the strings was investigated using atomic force microscopy and the low level resistance measurement method. Increasing the number of wear cycles increased the surface roughness and material removal, identified by increased electrical resistance of the strings. The increase in the resistance and frequency were due to both a reduction and variations in the cross sectional area caused by wear.
Harmonizing solubility measurement to lower inter-laboratory variance – progress of consortium of biopharmaceutical tools (CoBiTo) in Japan

The purpose of the present study was to harmonize the protocol of equilibrium solubility measurements for poorly water-soluble drugs to lower inter-laboratory variance. The “mandatory” and “recommended” procedures for the shake-flask method were harmonized based on the knowledge and experiences of each company and information from the literature. The solubility of model drugs was measured by the harmonized protocol (HP) and the non-harmonized proprietary protocol of each company (nonHP). Albendazole, griseofulvin, dipyridamole, and glibenclamide were used as model drugs. When using the nonHP, the solubility values showed large inter-laboratory variance. In contrast, inter-laboratory variance was markedly reduced when using the HP.
Influence of Age, Ethnicity and Sex on Body Composition Thresholds for the Accumulation of Visceral Adipose Tissue in Adults

The purpose of this study was to investigate the influence of age, ethnicity, and sex on the body fat percentage (BF%) threshold, the point above which visceral adipose tissue (VAT) increases more rapidly. Participants were 1,756 females and 1,455 males, 18-75 years of age, who had a dual X-ray absorptiometry scan. Using segmented linear regression models for each sex and ethnicity category, the BF% thresholds were identified. The BF% thresholds for females were: Asian 29.2%, Black 35.6%, Hispanic 31.7%, and White 34.2%. For males, they were: Asian 25.3%, Black 23.9%, Hispanic 24.3%, and White 22.8%. Post-threshold, the impact of BF% was amplified for older females (β = 0.28, SE =0.03, p < .001) and males (β = 0.81, SE = 0.06, p < .001). BF% had a weaker association with VAT mass for Black compared to White females (β = -3.05, SE = 1.44, p < .05) and Asian compared to White males (β = -11.40, SE = 2.30, p < .001). The BF% threshold was higher in females and varied more with ethnicity in females. Post-threshold the association of BF% with VAT differed by age and ethnicity, although the influence of ethnicity was different in females than males.
Influence of the patient size on secondary doses delivered in light ion beams (The 12th International Conference on Radiation Shielding (ICRS-12) and the 17th Topical Meeting of the Radiation Protection and Shielding Division of ANS (RPSD-2012)) -- (Medical Applications)

*Secondary radiation exposure of patients in light ion therapy is of concern due to possible normal tissue damage and risk of induction of secondary cancers. Neutrons, protons and heavier ions are generated by nuclear inelastic interactions of primary ions both in the beam line and in the patient. The patient is exposed to a complex radiation field and secondary doses can be deposited in normal tissues both close to and relatively far from the treated volume. The energy distribution of secondary particles and secondary doses delivered to different organs were studied by the MC code SHIELD-HIT10 using the anthropomorphic phantoms representing a 10-year-old child (CHILD-HIT) and an adult male (ADAM-HIT). Brain tumor irradiations were simulated with approximated scanned beams of 1 H, 7 Li and 12 C ions. The influence of patient size on the secondary dose distributions were studied using the same target definition and irradiation geometry with a lateral beam. For the scanned beams, the secondary organ absorbed doses normalized per absorbed dose to the treated volume (brain tumor) were in the range 1 nGy/Gy - 0.1 mGy/Gy and the absorbed doses in the CHILD-HIT phantom were higher than in ADAM-HIT by up to a factor of 5, depending on organ.
MCM 2 – 7 Complexes Bind Chromatin in a Distributed Pattern Surrounding the Origin Recognition Complex in Xenopus Egg Extracts

The MCM2–7 complex is believed to function as the eukaryotic replicative DNA helicase. It is recruited to chromatin by the origin recognition complex (ORC), Cdc6, and Cdt1, and it is activated at the G1/S transition by Cdc45 and the protein kinases Cdc7 and Cdk2. Paradoxically, the number of chromatin-bound MCM complexes greatly exceeds the number of bound ORC complexes. To understand how the high MCM2–7:ORC ratio comes about, we examined the binding of these proteins to immobilized linear DNA fragments in Xenopus egg extracts. The minimum length of DNA required to recruit ORC and MCM2–7 was 80 bp, and the MCM2–7: ORC ratio on this fragment was 1:1. With longer DNA fragments, the MCM2–7:ORC ratio increased dramatically, indicating that MCM complexes normally become distributed over a large region of DNA surrounding ORC. Only a small subset of the chromatin-bound MCM2–7 complexes recruited Cdc45 at the onset of DNA replication, and unlike Cdc45, MCM2–7 was not limiting for DNA replication. However, all the chromatin-bound MCM complexes may be functional, because they were phosphorylated in a Cdc7-dependent fashion, and because they could be induced to support Cdk2-dependent Cdc45 loading. The data suggest that in Xenopus egg extracts, origins of replication contain multiple, distributed, initiation-competent MCM2–7 complexes.
Feasibility of Reuse of Effluent from the Extended Aeration Process of Wastewater Treatment Plant in the Bojnoord City for Agricultural and Irrigation Uses

Background and Objective: Due to increasing the water demand and the lack of its resources, the reuse of effluents is considered as a useful option in the water resources management. The aim of this study was to evaluate the possibility of the reuse of effluents from the extended aeration process in the wastewater treatment plant of the Bojnoord city for agricultural uses. Materials and Methods: This is a descriptive-analytical study which performed in 2013 on the quality of effluents in the wastewater treatment plant of the Bojnoord city by measuring the parameters of Electrical Conductivity (EC), Chemical Oxygen Demand (COD), Biological Oxygen Demand (BOD), nitrogen, phosphorus, Total Suspended Solids (TSS), Total Dissolved Solids (TDS), Sodium Adsorption Ratio (SAR), sodium percentage, magnesium ions, potassium ions, calcium ions, sodium ions
Glutathione S-transferase P1 and DNA Polymorphisms with the Response to Chemotherapy and the Prognosis of Bone Tumor

Osteosarcoma is the most common primary bone malignancy in children and adolescents, and its clinical outcome is poor. We evaluated the response of GSTP1, ERCC1 and ERCC2 to chemotherapy among osteosarcoma patients, and the role of these genes on the prognosis of osteosarcoma. 187 patients with osteosarcoma were administered with methotrexate, cisplatin/adriamycin, actinomycin D, cyclophosphamide, or vincristine treatment. GSTP1, ERCC1 and ERCC2 polymorphism was genotyped by PCR-RFLP assay. The results showed the average survival time of 187 patients were 38.4 months. 97 patients showed response to neoadjuvant chemotherapy. The GSTP1 Val and ERCC2 A/A genotypes had significantly higher rates of response to chemotherapy, with adjusted OR (95% CI) of 2.19 (1.15-6.21) and 2.88 (1.14-13.25). Individuals with ERCC2 A/A genotype were likely to have a lower risk of death from oseosarcoma, and the adjusted HR was 0.32 (0.13-0.95). Our study indicated test of GSTP1 and ERCC2 Lys751Gln polymorphisms might be a candidate pharmacogenomic factors to be explored in the future to identify the osteosarcoma patients who might benefit from chemotherapy.
OF JUBILEE INSURANCE COMPANY OF KENYA LIMITED TO CHANGING ENVIRONMENTAL CONDITIONS

The main objective of this study was to identify responses o f Jubilee Insurance to the changing environmental conditions. The study also sought to determine the forces of change in the external environment of Jubilee. This study was occasioned by the realization that Jubilee Insurance has been experiencing environmental turbulence such as rapid political, economic, technological and socio-cultural changes. Also, little research has been undertaken in this area. The few researches done for example those of Mriti (2010) on responses by Fidelity Insurance to the changing environment and Keranga (2009) on responses by Government of Kenya Press to the external environment were never exhaustive. This study adopted a case study approach of the Jubilee Insurance firm. Data was collected by using an interview guide. The researcher himself interviewed all the top ten managers of Pensions, Finance, Human resource, Business Development, Operations, Marketing, Public Relations, ICT, Legal and Underwriting departments. Data was analyzed by content analysis. The study findings indicate that the Jubilee Insurance faced challenges in terms of increased competition, changes in customer tastes and preferences, technology and economic changes. The study findings identified various response strategies by Jubilee Insurance. These included generic strategies of cost leadership, differentiation and focus. Strategic leadership was identified as the most important Strategic response by jubilee insurance. Other responses included product diversification, market development and use of modem technology as well as the use of marketing strategies like improved distribution and fair pricing. The findings of the study imply that Jubilee Insurance should invest more in R&D, Innovations and the creation of a learning culture. The study faced constraints of lack of enough time, resources and unwillingness of the interviewees to give the correct responses. It is hoped that the findings of this study will be o f great value to various groups like other industry players, the Jubilee management and scholars. Given the limitations, the researcher did not fully cover the objectives set out and therefore recommends that further research be done on the nature of competition posed by Jubilee Insurance’s other markets outside Kenya and the role of strategy in the growth of Jubilee Insurance business.
Could Immunophenotype Guide Molecular Analysis in Patients with Myeloid Malignancies

OBjeCTive: Immunophenotype has been correlated with molecular aberrations in several studies. The aim of this study was the discovery of immunophenotypic features related to mutations in AML and MDS patients connected to prognostic factors. Moreover, an effort to evaluate a method for the detection of the most common Nucleophosmin (NPM1) mutations of exon12 and Internal Tandem Duplications (ITD) mutations of FLT3 gene by flow cytometry was performed. MeThOd: Patients with de novo myeloid neoplasms [AML and MDS (AML-M3 patients were excluded)] were included. FLT3/ITD/TKD and NPM1 mutations were detected by PCR and fragment analysis. The immunophenotypic analysis was performed by multi-dimensional flow cytometry (FC) with a standardized panel of monoclonal antibodies on peripheral blood or bone marrow samples. Nucleophosmin Antibody and CD135 were used for the mutations immunophenotypic detection. ReSulTS: NPM1 and/or FLT3 mutations correlated with low or no expression of more immature cells markers such as CD34, CD117, HLADR, as well as higher expression of more mature markers such as CD11b. The higher expression of CD33 should be mentioned as well. The presence of NPM1mut and FLT3/ITD does not seem to be detectable by FC at least using these two monoclonal antibodies. The presence of CD7 aberrant lymphoid marker’s expression was associated with FLT3mut, NPM1wt genotype. CD56 or CD2 positivity was found only in patients’ samples negative for NPM1 and/or FLT3 mutations. COnCluSiOnS: Certain immunophenotype findings including the presence of aberrant lymphoid markers may be indicative of the presence of mutations in NPM1 and FLT3 linked to prognosis. ORiginAl ARTiCle Department of HaematologyLymphomas and BMT Unit, “Evangelismos” General Hospital of Athens, Greece Department of Immunology and Histocompatibility, “Evangelismos” General Hospital of Athens, Greece Haematology Department, Hippocratio Hospital Athens Greece, National and Kapodistrian University of Athens Microbiology and Immunology Department, National and Kapodistrian University of Athens Haematology Unit of the 3 Internal Medicine Clinic, Sotiria General Hospital Athens Medical School, Athens Greece HOSPITAL CHRONICLES 2019, 14(1): 13–23 Correspondence to: Eirini Tziotziou, Department of Molecular Biology Lab, Department of Haematology-Lymphomas and BMT Unit, “Evangelismos” General Hospital of Athens, 45-47, Ipsilandou street, 10676 Athens, Greece Tel. : +3
Submission to Work and Pensions Committee Intergenerational Fairness Inquiry

 In recent history each generation has tended to be better off than the last as national income has risen. But this trend has now stalled: those born in the 1960s and 1970s have no higher incomes than those born ten years earlier had at the same age. Younger generations also face an economic and policy environment in which it is harder to accumulate wealth for retirement than it was for their predecessors: it is harder to become a homeowner, private pension schemes are less generous on average, and the state pension will replace a smaller share of earnings on average. On the other hand, those in younger generations expect to inherit much more than older generations did.