Miracle-dz/UniFAR-FTUs huggingface dataset:
Indian media professionals’ perspectives regarding the role of media in suicide prevention and receptiveness to media guidelines: a qualitative study

Objectives Crime reports of suicide incidents routinely feature in the Indian mass media, with minimal coverage of suicide as a broader public health issue. To supplement our recently published content analysis study, we undertook qualitative interviews to examine media professionals' perspectives and experiences in relation to media reporting of suicide-related news in India. Design and setting In 2017–2018, we undertook semistructured qualitative interviews with media professionals with experience reporting on suicide-related news. A semistructured interview guide was designed to initiate discussions around their perspectives and experiences in relation to reporting on suicide. Interviews were digitally audio-recorded and transcribed, and a deductive and inductive approach to thematic analysis was used. Participants Twenty-eight interviews were undertaken with media professionals in Delhi, Chandigarh and Chennai. Results A clear role for media in suicide prevention framed around educating and informing the public was articulated by several participants and a majority of participants also reported concerns and anecdotal accounts that their reporting may negatively influence vulnerable people in the population. Nonetheless, a fatalistic attitude towards suicide was evident among several participants including dismissing or minimising concerns around imitation suicides. Several participants also expressed doubts around the quality of suicide helplines in India and were hesitant to add such contact details to their reports. Participants were largely very receptive to the idea of developing voluntary media guidelines for the Indian context, although doubts were raised around compliance unless additional initiatives were taken to engage media professionals at the highest levels. Conclusions Our findings reveal the perspectives of media professionals operating in the Indian context and can be used to support constructive partnerships between media professionals and suicide prevention experts. There is a clear need for a genuine and sustained partnership between suicide prevention experts and media professionals at all levels.
Effect of overlying water pH, temperature, and hydraulic disturbance on heavy metal and nutrient release from drinking water reservoir sediments

How environmental factors impact the release of pollutants from sediment is critical to ensure the safety of drinking water, especially when the seasons change. Here, we investigated the effect of water pH, temperature, and hydraulic disturbance on the release of heavy metals and nutrients from the sediment of drinking water reservoir. The results show that lower initial water pH promoted the Zn release, while low temperature enhanced the Mn flux after 15 days. Meanwhile, continuous disturbance caused more metals releasing from sediment than intermittent disturbance due to greater shear stress and turbulence effect. However, intermittent high‐speed disturbance greatly altered the dynamic release of Zn from L‐shaped curve to U‐shape in water column. Moreover, lower water pH caused higher ammonium in water but lower nitrate since H+ restrained the nitrification. Yet, higher temperature inhibited the release of ammonium from sediment, which might relate to the accelerated mineralization of organic nitrogen and elevated dissolved oxygen caused by the algae growth. Notably, hydraulic disturbance with various intensity and duration greatly influenced the fluxes of various species of nitrogen and soluble phosphate in water column, because the disturbance facilitated the nitrogen and phosphorus exchanges between sediment–water and water–air interfaces.
Plasma pre-treatment T790M relative allelic frequency in patients with advanced EGFR-mutated non-small cell lung cancer predicts treatment response to subsequent-line osimertinib

Background Approximately half of all patients with advanced EGFR-mutant NSCLC will develop acquired resistance to first or second-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) with a T790M mutation. In the AURA3 trial, patients with a T790M mutation had a response rate of 71% to osimertinib, a third-generation EGFR-TKI. The response to osimertinib may vary according to plasma T790M mutation frequency. Our aim was to determine the effect of plasma T790M mutation load on treatment response to osimertinib in an Australian multi-institutional cohort. Methods We performed a retrospective study on patients treated with osimertinib in the second-line setting and beyond between 2016–2018 from ten centres in Australia, who had T790M mutations detected in tumour or plasma. The primary objective was to investigate if there was a difference in disease control rate (DCR) between patients with high vs. low T790M relative allelic frequency (RAF) as detected in plasma, using a 0.3 RAF cut-off, as determined by ddPCR or BEAMing PCR. Secondary objective was to determine the survival outcomes according to high versus low plasma T790M RAF. Additional analyses were performed to investigate the survival outcome for patients with plasma versus tissue T790M positivity. Results A total of 139 patients were included in this study. Patients with higher RAF demonstrated higher DCR (74% vs. 36%, P=0.02), however there was no statistically significant difference in survival outcomes in the two groups. Exploratory analysis showed that patients with tissue T790M+ had improved DCR compared with those with plasma T790M+ (89% vs. 68%, P=0.01) and longer progression free survival (median 15.4 vs. 9.7 months; HR 0.51, 95% CI: 0.34 to 0.77, P=0.003) and overall survival (median not reached, HR 0.51, 95% CI: 0.30 to 0.86, P=0.02). Patients who were tissue T790M+ demonstrated superior survival compared to plasma T790M+ after correcting for confounding variables in a multivariate model. Conclusions DCR was superior in patients with higher plasma T790M mutation load versus lower plasma T790M mutational load, without significant survival benefit. Plasma T790M RAF is a potential predictive biomarker which should be investigated and validated in larger prospective studies.
Ultrasound features and risk stratification systems to identify medullary thyroid carcinoma.

OBJECTIVE Recently, several scientific societies designed ultrasound (US) risk stratification systems (RSS) to guide the work-up of thyroid nodules and decide which nodules should undergo fine needle aspiration cytology (FNAC). However, these systems have been developed against papillary thyroid carcinoma, and scanty data on their role in identifying medullary thyroid carcinoma (MTC) are available. The aims of this study are to describe the US features of MTC and evaluate the performance of RSS in identifying MTC. METHODS We evaluated data of 152 consecutive patients with MTC. We collected the results of the pre-operative neck US of all patients. Ultrasound features of each MTC were evaluated and classified according to the 5 main RSS available. RESULTS Median MTC dimension was 1.3 cm. Most of the nodules showed solid composition, hypoechoic pattern, and regular margins. About half of them showed the presence of calcifications, but only a subgroup had microcalcifications. A minority of the nodules showed a "taller than wide" shape. Only 7.9% of all MTC showed the simultaneous presence of at least 4 US features suggestive for malignancy. Ultrasonographic high-risk of malignancy of the MTC included in the 5 RSS, varied from 45.4 to 47.4%, and performing FNAC was suggested in only 48.7-63.8% of all MTC. CONCLUSIONS In our series neither single nor association of US features are specific for MTC. The 5 main RSS correctly identify less than 50% of MTC and do not suggest of performing FNAC in about half of them with potentially missed or delayed diagnosis.
Inter-episodes earthquake migration in the Bohai-Zhangjiakou Fault Zone, North China: Insights from numerical modeling

In this paper, we focus on why intraplate seismic initiation and migration occurs, which has widely been considered to be caused by static stress triggering caused by earthquakes, as well as post-seismic slips. To illustrate the mechanism underlying large earthquakes, in particular the migration caused by two key episodes that occurred after 1500 in the Bohai-Zhangjiakou Fault Zone (BZFZ) of North China, we developed a high-resolution three-dimensional viscoelastic finite element model that includes the active faults with vertical segmentation, their periodical locking, and the lithosphere heterogeneity. We used the birth and death of element groups to simulate stress intensity changes during the two episodes (named Episode I and II), with our results showing that the Tangshan earthquake was primarily triggered by the Sanhe-Pinggu M8.0 earthquake in 1679, whereas the Zhangbei M6.2 earthquake in 1998 was not triggered by earthquakes in Episode I. According to our work, the calculated stress changes in the different segments of the fault zone correspond to the magnitude of the triggered earthquakes. Further, the largest stress decrease was near the Sanhe-Pinggu fault and occurred the largest earthquake in Episode I, whereas the largest stress increase was near the Tangshan fault and occurred during the largest earthquake in Episode II. Given the above, we propose a model for seismic migration to describe the dynamic mechanisms of earthquake migration within the BZFZ and North China, in which the factors affecting both the seismic migration path and intensity primarily include the distance between the triggered active fault and the original fault, the coupling of the active faults, the location and scale of the low-velocity anomaly, its distance from the active fault, and the location and scale of the crustal thinning.
Mechanisms of m-dinitrobenzene-induced selective neurotoxicity and the roles of brain glutathione

m-Dinitrobenzene (m-DNB) is a neurotoxin producing selective damage in the brain stem. The mechanisms of the selective neurotoxicity induced by this compound have been investigated in this project. In vitro studies demonstrated that brain has considerable nitroreductive capacity towards m-DNB. m-Mtroaniline was the main metabolite produced, attaining up to 66% of the original concentration of m-DNB while nitrosonitrobenzene was also detectable in brain slices. Glutathione (GSH) and ascorbic acid were able to chemically reduce nitrosonitrobenzene. The results indicate that in situ reduction of m-DNB may play an important role in the m-DNB-induced neurotoxicity. Both GSH and ascorbic acid were lower in normal brain stem. Striatum had the highest level of GSH while hippocampus had the highest level of ascorbic acid. In contrast, free, malondialdehyde (MDA) was higher in the brain stem than the other areas. Brain stem areas were more sensitive to the BSO-induced GSH depletion since GSH half life in those areas were shorter than in other brain areas. These results indicate a lower antioxidant capacity and a higher spontaneous oxidative stress in brain stem. This may partially explain the susceptibility of brain stem to neurotoxic xenobiotics. In order to test the hypothesis that GSH status in brain plays an important role in the selective neurotoxicity of m-DNB, the susceptibility of the rat to intoxication was studied in 6 month old animals that show naturally lower GSH levels in brain and also in young adult animals treated with BSO to deplete brain GSH. Control adult animals developed brain stem lesions after 4 doses of m-DNB (4xl0mg/kg); but 6 month old animals showed these changes after 3 doses, while BSO-treated animals had brain stem lesions after only 1 dose of DNB. This demonstrated that brain GSH status is likely to be an important factor in determining regional sensitivity to gliovascular damage induced by m-DNB. Selective GSH depletion in rat brain caused generalised seizures and running fits which could be prevented by maintaining brain GSH levels with co-administration of y-glutamylcysteine (y-GC) into the brain. These observations suggest a primary involvement of GSH in modulating excitability of the central nervous system (CNS). A close parallel between developmental changes of hippocampal GSH and cysteine suggests that cysteine may be a rate limiting factor for brain GSH synthesis during the early period of life.
Race and other sociodemographic categories are differentially linked to multiple dimensions of interpersonal-level discrimination: Implications for intersectional, health research

Objectives To examine whether intersections of race with other key sociodemographic categories contribute to variations in multiple dimensions of race- and non-race-related, interpersonal-level discrimination and burden in urban-dwelling African Americans and Whites. Methods Data from 2,958 participants aged 30–64 in the population-based Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study were used to estimate up to four-way interactions of race, age, gender, and poverty status with reports of racial and everyday discrimination, discrimination across multiple social statuses, and related lifetime discrimination burden in multiple regression models. Results We observed that: 1) African Americans experienced all forms of discrimination more frequently than Whites, but this finding was qualified by interactions of race with age, gender, and/or poverty status; 2) older African Americans, particularly African American men, and African American men living in poverty reported the greatest lifetime discrimination burden; 3) older African Americans reported greater racial discrimination and greater frequency of multiple social status-based discrimination than younger African Americans; 4) African American men reported greater racial and everyday discrimination and a greater frequency of social status discrimination than African American women; and, 5) White women reported greater frequency of discrimination than White men. All p’s < . 05. Conclusions Within African Americans, older, male individuals with lower SES experienced greater racial, lifetime, and multiple social status-based discrimination, but this pattern was not observed in Whites. Among Whites, women reported greater frequency of discrimination across multiple social statuses and other factors (i.e., gender, income, appearance, and health status) than men. Efforts to reduce discrimination-related health disparities should concurrently assess dimensions of interpersonal-level discrimination across multiple sociodemographic categories, while simultaneously considering the broader socioecological context shaping these factors.
Effect of a Real-Time Risk Score on 30-day Readmission Reduction in Singapore

Abstract Objective To develop a risk score for the real-time prediction of readmissions for patients using patient specific information captured in electronic medical records (EMR) in Singapore to enable the prospective identification of high-risk patients for enrolment in timely interventions. Methods Machine-learning models were built to estimate the probability of a patient being readmitted within 30 days of discharge. EMR of 25,472 patients discharged from the medicine department at Ng Teng Fong General Hospital between January 2016 and December 2016 were extracted retrospectively for training and internal validation of the models. We developed and implemented a real-time 30-day readmission risk score generation in the EMR system, which enabled the flagging of high-risk patients to care providers in the hospital. Based on the daily high-risk patient list, the various interfaces and flow sheets in the EMR were configured according to the information needs of the various stakeholders such as the inpatient medical, nursing, case management, emergency department, and postdischarge care teams. Results Overall, the machine-learning models achieved good performance with area under the receiver operating characteristic ranging from 0.77 to 0.81. The models were used to proactively identify and attend to patients who are at risk of readmission before an actual readmission occurs. This approach successfully reduced the 30-day readmission rate for patients admitted to the medicine department from 11.7% in 2017 to 10.1% in 2019 (p < 0.01) after risk adjustment. Conclusion Machine-learning models can be deployed in the EMR system to provide real-time forecasts for a more comprehensive outlook in the aspects of decision-making and care provision.
Effects of experimental warming on Betula nana epidermal cell growth tested over its maximum climatological growth range

Numerous long-term, free-air plant growth facilities currently explore vegetation responses to the ongoing climate change in northern latitudes. Open top chamber (OTC) experiments as well as the experimental set-ups with active warming focus on many facets of plant growth and performance, but information on morphological alterations of plant cells is still scarce. Here we compare the effects of in-situ warming on leaf epidermal cell expansion in dwarf birch, Betula nana in Finland, Greenland, and Poland. The localities of the three in-situ warming experiments represent contrasting regions of B. nana distribution, with the sites in Finland and Greenland representing the current main distribution in low and high Arctic, respectively, and the continental site in Poland as a B. nana relict Holocene microrefugium. We quantified the epidermal cell lateral expansion by microscopic analysis of B. nana leaf cuticles. The leaves were produced in paired experimental treatment plots with either artificial warming or ambient temperature. At all localities, the leaves were collected in two years at the end of the growing season to facilitate between-site and within-site comparison. The measured parameters included the epidermal cell area and circumference, and using these, the degree of cell wall undulation was calculated as an Undulation Index (UI). We found enhanced leaf epidermal cell expansion under experimental warming, except for the extremely low temperature Greenland site where no significant difference occurred between the treatments. These results demonstrate a strong response of leaf growth at individual cell level to growing season temperature, but also suggest that in harsh conditions other environmental factors may limit this response. Our results provide evidence of the relevance of climate warming for plant leaf maturation and underpin the importance of studies covering large geographical scales.
COVID-19 healthcare policies in Ireland: A rapid review of the initial pandemic response

Aims: Healthcare systems urgently required policies to guide the response to the COVID-19 pandemic. The aim of this review was to document the healthcare policies developed during the initial wave of widespread COVID-19 transmission in Ireland. We further sought to determine the key focus and impact of these policies. Methods: We conducted a rapid review of COVID-19 healthcare policies published from 28 January to 31 May 2020. Key information including the focus of the policy, target population and impact on service delivery was extracted from included policies. During analysis, data was grouped under descriptive categories and narrative summaries were developed for each category. Results: We identified 61 healthcare policies relating to COVID-19. We developed six category headings to describe the focus and impact of these policies: infection prevention and control (n = 19), residential care settings (n = 12), maintaining non-COVID-19 healthcare services and supports (n = 12), testing and contact tracing (n = 7), guidance for healthcare workers concerning COVID-19 (n = 6), and treating COVID-19 (n = 5). Conclusions: This review has identified lessons for policy development and implementation to help prepare for future healthcare emergencies. Factors to consider include support of vulnerable groups during and in the aftermath of the pandemic, providing psychological supports for healthcare workers and investment in public healthcare services such as contact tracing for future emergencies. While pandemic conditions necessitate the speedy development of policies, effective communication and adequate resourcing is required to ensure policy implementation.
Association between household income and pulse pressure: data from the Korean National Health and Nutrition Examination Survey

Abstract Purpose There has been limited evidence for the association between socioeconomic status (SES) and arterial stiffness. This study was performed to investigate the association between household income and brachial pulse pressure (PP) in the general Korean population. Materials and methods This study was based on data acquired in the 2018 Korea National Health and Nutrition Examination Survey (2018 KNHANES). A total of 13004 subjects at the age of 20 years or older analysed. The information on monthly household income was obtained through the questionnaire, and was stratified into 5 groups for each quintile. Brachial blood pressure (BP) was measured 3 times, and the average of the second and third measured BPs were used. PP was calculated as the difference between systolic and diastolic BPs. Results A lower household income was associated with a higher prevalence of cardiovascular risk factors. As household income increased, PP decreased proportionally (p < .001). In multiple linear regression analysis, household income (per quintile) was independently associated with PP even after controlling for potential confounders (β = −.125, p < .001). Multiple binary logistic regression analysis showed that the increased household income level was significantly associated lower probability having higher PP (≥ 43.5 mmHg) even after controlling for multiple covariates (the lowest vs. the highest household income; odds ratio, 0.48; 95% confidence interval, .41–.55; p < .001). Conclusion Low household income was associated with higher PP. This provides additional evidence for the association between low SES and high arterial stiffness.
Extracellular acidosis enhances Zika virus infection both in human cells and ex-vivo tissue cultures from female reproductive tract

ABSTRACT Zika virus (ZIKV) is a flavivirus transmitted by mosquitoes of the genus Aedes, but unlike other flaviviruses, ZIKV can be sexually transmitted by vaginal intercourse. The healthy vaginal pH ranges from 4.0 to 6.0, reaching values of 6.0–7.0 after semen deposition. Here, we report that low extracellular pH values (range 6.2–6.6) dramatically increase ZIKV infection on cell lines of different origin including some derived from the female genital tract and monocyte-derived macrophages. Furthermore, low pH significantly increased ZIKV infection of human ectocervix and endocervix cultured ex-vivo. Enhancement of infection by low pH was also observed using different ZIKV strains and distinct methods to evaluate viral infection, i.e. plaque assays, RT–PCR, flow cytometry, and fluorescence microscopy. Analysis of the mechanisms involved revealed that the enhancement of ZIKV infection induced by low pH was associated with increased binding of the viral particles to the heparan sulphate expressed on the target cell surface. Acidosis represents a critical but generally overlooked feature of the female genital tract, with major implications for sexual transmission diseases. Our results suggest that low vaginal pH might promote male-to-female transmission of ZIKV infection.