Miracle-dz/UniFAR-FTUs huggingface dataset:
What portion of the soft tissue artefact requires compensation when estimating joint kinematics?

When joint kinematics is analyzed using noninvasive stereophotogrammetry, movements of the skin markers relative to the underlying bone are regarded as artefacts (soft tissue artefact (STA)). Recent literature suggests that an appropriate estimation of joint kinematics may be obtained by compensating for only a portion of the STA, but no evidence for this case has been reported, and which portion of the STA should be selected remains an issue. The aim of this study was to fill this gap. A modal approach was used to represent the STA. This resulted in a series of additive components (modes) and in the possibility to select a subset of them. The following STA definitions were used: individual skin marker displacement (MD), marker-cluster geometrical transformation (GT), and skin envelope shape variation (SV). An STA approximation for each of the three definitions was obtained by ordering modes on the basis of their contribution to the total STA energy and truncating the relevant series at 90% of it. A fourth approximation was obtained when the GT definition was used, by selecting the modes that represented the marker-cluster rigid transformation (i.e., three translation and three rotation modes). The different STA approximations were compared using data obtained during the stance phase of running of three volunteers carrying both pin and skin markers. The STA was measured and knee joint kinematics estimated using four skin marker datasets compensated for the above-mentioned STA approximations. Accuracy was assessed by comparing results to the reference kinematics obtained using pin markers. The different approximations resulted in different numbers of modes. For joint angles, the compensation efficiency across the STA approximations based on an energy threshold was almost equivalent. The median root mean square errors (RMSEs) were below 1 deg for flexion/extension and 2 deg for both abduction/adduction and internal/external rotation. For the joint displacements, the compensation efficiency depended on the STA approximation. Median RMSEs for anterior/posterior displacement ranged from 1 to 4 mm using either MD, GT, or SV truncated series. The RMSEs were virtually null when the STA was approximated using only the GT rigid modes. This result, together with the limited number of modes used by this approximation (i.e., three translations and three rotations of the marker-cluster), makes the STA rigid component and a good candidate for designing an STA model to be incorporated in an enhanced bone pose estimator.
Hyaline Membrane Disease: Pathogenesis and Pathophysiology

a mydriatic test performed two weeks later was negative. Her visual acuity improved to 6/9 with her contact lens and no visual field loss was detected. To our knowledge angle closure, without pupillary block, following Nd-YAG laser capsulotomy has not previously been reported. A rise in intraocular pressure, which may exceed 50 mmHg, is a well documented complication of this procedure, but timolol and/or acetazolamide have hitherto been used successfully in treatment. Explanations which have been given for the pressure rise include diminished outflow facility resulting from deposition of debris in the trabecular meshwork4; neurovascular mechanisms'; trabeculitis as a result of the radiating shock wave6; and pupillary block. ' In this case it was initially considered that inflammatory swelling of the ciliary body secondary to the pressure wave was the most likely pathogenetic mechanism of angle closure, which provided the rationale for the use of steroid. However, pilocarpine successfully reduced the intraocular pressure, implicating such mechanisms as angle crowding due to swelling of the iris root or ciliary body. This report serves to illustrate that careful observation and follow-up is warranted for all patients undergoing NdYAG laser treatment to the eye, as hitherto unreported complications are likely to be observed when this novel treatment becomes more widely used. *Ophthalmology Department, CAROLINE J MACEWEN* Gartnavel General Hospital, GORDON N DUTrrONt Glasgow DEIRDRE HOLDING* tTennent Institute of Ophthalmology, Western Infirmary, Glasgow
Community-Based Prevention Marketing

a Associate Professor in the Department of Community and Family Health, University of South Florida, Deputy Director of the Florida Prevention Research Center b Assistant Professor in the Department of Community and Family Health, University of South Florida, Director of the Florida prevention Research Center's Research and Evaluation Unit c Associate Professor in the Department of Community and Family Health, University of South Florida d Chair of the Department of Community and Family Health, University of South Florida, Director of the Florida Prevention Research Center e Visiting Professor at the University of Cologne, Germany f Visiting Professor at the University of Freiburg, Germany
Veterinary Laboratory Medicine: Interpretation and Diagnosis

Part I: General Discussions. Laboratory Medicine Testing: Specimen Interferences and Clinical Enzymology. Hematopoiesis and Evaluation of the Bone Marrow. Evaluation of Erythrocytic Disorders. Evaluation of Leukocytic Disorders. Evaluation of Hemostasis: Coagulation and Platelet Disorders. Evaluation of Immune-Mediated Disease and Hyperglobulinemia. Evaluation of the Hepatobiliary System and Skeletal Muscle and Lipid Disorders. Evaluation of Exocrine Pancreatic, Intestinal Tract, And Glucose Disorders. Evaluation of Endocrine Function. Assessment of Renal Function, Urinalysis, And Water Balance. Electrolyte and Acid-Base Homeostasis and Disorders. Examination of Cerebrospinal Fluid. Evaluation of Effusions. Examination of Synovial Fluid. The Microscopic Examination of Tissue Specimens Obtained By Fine-Needle Aspiration Biopsy. Part II: Case Histories. Part III: Algorithms. Part IV: Appendix: Normal Values and Conversion Tables. Index.
Intelligent learning agent for collaborative virtual workspace

Purpose – Intelligent agents are becoming an essential part of collaborative virtual environments. The purpose of this paper is to present an architecture of a learning agent that is able to utilize machine learning techniques to monitor the user's actions.Design/methodology/approach – A learning agent is developed and integrated into federated collaborative virtual workspace.Findings – The experimental results showed that the combination of genetic algorithms and reinforcement learning algorithms provides the agent with better learning capability resulting in better predictions for the user.Originality/value – This paper provides experimental results and a performance analysis in terms of accuracy of predictions, processing time, and memory utilization of the agent.
MORTALITY AND MORBIDITY STATISTICS

To the Editor:— I should like to call attention to a common fallacy in the presentation of mortality and morbidity statistics, which is illustrated again by an article by Grulee, Sanford and Herron on breast and artificial feeding inThe Journal, September 8. The fallacy consists in reporting the mortality for a group under the supervision of an organization and then comparing it with the mortality of the city or state or nation as a whole. In this article, for instance, it is stated that the mortality for the group under the care of the Infant Welfare Society of Chicago was 11.1, which was less than one fourth of the infant mortality of the same region. Now the infant mortality of the same region is made up of all the deaths of infants from the very moment of birth. The mortality of the group under the supervision of the Infant
Influencing public awareness to prevent male suicide

Purpose – The purpose of this paper is to report findings from a formative evaluation of a suicide prevention public awareness campaign – Choose Life, North Lanarkshire. The focus is on preventing male suicide. The paper explores how the public campaign supports a co-ordinated and community-based direction for suicide prevention work, and examines how good practice can be identified, spread, and sustained. Design/methodology/approach – The paper draws on data collected from March to November 2011, using mixed primary research methods, including a quota survey, discussion groups with the general public, and stakeholder interviews. Findings – The campaign effectively raised the suicide awareness of a substantial proportion of those targeted, but with regional variations. It also affected the attitudes and behaviour of those who were highly aware. However, men and women engaged somewhat differently with the campaign. The sports and leisure settings approach was effective in reaching younger men. Practical im.
Rotordynamic Evaluation of Full Scale Rotor on Tilting Pad Bearings With Integral Squeeze Film Dampers

In the last 10 years, major centrifugal compressor manufacturers have been investing in developing technologies to improve their products. Following the increasing demand in terms of performance, efficiency and compactness, the current trend in the compressor industry is to increase the “power density”. One big challenge of this “power density” approach is the increase of the rotational speed which may be related to rotordynamic concerns (e.g. crossing of higher rotor modes, stability). Commonly used in the aircraft gas turbines [16], the squeeze film dampers represent an efficient solution to deal with high vibrations and to ensure stable operation for supercritical rotors. In the Oil & Gas Centrifugal Compressors world, SFDs are not so often utilized by the manufacturers but sometimes chosen by the end users as a retrofit solution when high level of synchronous/sub-synchronous vibrations are experienced in the field. The experimental activities described in this paper represent the authors’ Company effort to validate the behavior of a special, integrated SFD type in order to add this component in the available technology portfolio of a centrifugal compressor using it since the design phase. To accomplish this target, the SFD testing was performed originally at the component level and finally at a system level on a “dummy rotor”, specifically designed to mimic the rotordynamic behavior of a real rotor (e.g. running across both the two first rigid modes and the first bending mode). The main objectives of the testing activity were: to check the benefit of using SFDs in order to increase the rotor system damping, to check the SFD overall operational performances, and finally to validate the rotordynamic predictability of this new rotor system. The system level testing program was performed in a high speed balancing bunker where the rotor was equipped with a magnetic exciter able to deliver sub-synchronous excitation. The main test results which will be described in details in the paper are anticipated here. SFDs showed a significant increase in the damping of rigid modes compared to a baseline configuration (rotor running on traditional journal bearings); the SFDs behavior was fully assessed both from rotordynamic viewpoint (rotor and damper housing vibrations) and from operational viewpoint (oil temperature and pressures directly measured in the damper land); finally the rotor modal damping identification techniques are applied to this highly damped rotor system in order to compare the experiment with the relevant predictions. As a conclusion the testing activity provided the authors’ Company with confidence in the use of this integrated SFD technology and enabled a new option for centrifugal compressor design.Copyright © 2012 by ASME
A Study of the Exfoliative Cytology of the Hard Palate and Buccal Mucosa Following Cessation of Smoking in Previous Smokers

For many years investigators have tried to isolate the irritating properties found in cigarette smoke. Flinn' wrote in 1935 that he had conducted experiments with 100 individuals, testing two hygroscopic agents found in cigarettes. The results showed that glycerine was more irritating than diethylene glycol. Flinn's studies were an elaboration of the work done by Mulinos and Osborne.2 They had tested the irritating properties of the above-mentioned hygroscopic agents on the conjunctiva of rabbit eyes. It was noted then that glycerine was much more irritating than diethylene glycol. Ballinger and Johnson3 question the validity of their findings. Kreshover and Salley,4 in studying the effects of cigarette smoke on the oral tissue of mice and hamsters, noted no significant changes in these structures in their experimental procedures. Pindborg,5 studying human subjects, found some correlation between the use of tobacco and inflammatory changes in the gingiva. During the last 10 years, studies of the keratinization of the oral mucosa have been conducted by means of exfoliative cytology techniques. Montgomery6 showed that age, sex, and menstrual cycle did not significantly influence the "cell pattern" of the oral mucosa. Miller, Soberman, and Stahl7 demonstrated that the palate was the most highly cornified tissue of the oral cavity, the gingiva the next most highly cornified tissue, the dorsal of the tongue next, and the cheek least of all. This pattern remained constant through various ages. The present study will, by means of exfoliative cytology, investigate the keratinization of the hard palate and cheek following cessation of smoking in previous smokers. It will be further noted whether the cell pattern of the hard palate and cheek varies significantly from one individual to another.
Synthesizing Linear Array Algorithms from Nested For Loop Algorithms

The mapping of algorithms structured as depth-p nested FOR loops into special-purpose systolic VLSI linear arrays is addressed. The mappings are done by using linear functions to transform the original sequential algorithms into a form suitable for parallel execution on linear arrays. A feasible mapping is derived by identifying formal criteria to be satisfied by both the original sequential algorithm and the proposed transformation function. The methodology is illustrated by synthesizing algorithms for matrix multiplication and a version of the Warshall-Floyd transitive closure algorithm. >
Clinical course and side effects of anti-IgE monoclonal antibody in patients with severe persistent asthma.

BACKGROUND Omalizumab, a recombinant humanized monoclonal antibody to IgE, is recommended as a new option for the treatment of severe persistent allergic asthma. The purpose of this study is to assess the effects omalizumab treatment on life quality and its side effects in severe persistent asthma patients. METHODS In this study, we evaluated 19 severe persistent asthma patients who received therapy with omalizumab for 8 months. Omalizumab was administered every 2 weeks at doses between 150 to 375 mg. Symptoms and severity of allergic reactions were recorded before and after being on omalizumab. IgE levels, mean platelet volume (MPV), platelet levels, pulmonary function test, and asthma control test were evaluated in all patients before and 8 months after the treatment. Local and systemic side effects of omalizumab were evaluated. Stool parasites were examined in the 4th and 8th month after initiation of treatment to investigate any parasitosis. RESULTS The patients had severe persistent asthma for periods ranging from 3 to 8 years, and they were diagnosed with allergic asthma for 7 - 28 years. Thrombocytopenia developed in a male patient after the 22nd dose of the drug was given. When the platelet count fell down to 55000, the omalizumab treatment was suspended. During the therapy period, one patient had parasitosis (giardiasis), one patient had severe side effects, one patient had dyspnea two hours after the injection, and one patient had a dyspnea attack 2 hours after the injection. The changes in MPV levels were not statistically significant. There was also a significant decrease in IgE levels after the treatment. CONCLUSIONS Monitoring of complete blood cell count is very important when using this drug. Though we did not see anaphylaxis in any patients, we believe that the patients should be monitored at least for 3 hours after the omalizumab injection.
Adaptive signal processing JAVA applet

This publication presents a JAVA program for teaching the rudiments of adaptive digital signal processing (DSP) algorithms and techniques. Adaptive DSP is one of the most important areas of signal processing, and provides the core algorithmic means to implement applications ranging from mobile telephone speech coding, to noise cancellation, to communication channel equalization. Over the last 30 years, adaptive digital signal processing has progressed from being a strictly graduate level advanced class in signal processing theory to a topic that is part of the core curriculum for many undergraduate signal processing classes. The JAVA applet presented in this publication has been devised for students to use in combination with lecture notes and/or one of the recognised textbooks such that they can quickly and conveniently simulate algorithms, such as the LMS (least mean squares), RLS (recursive least squares) and so on, in a variety of applications without requiring them to write programs or scripts or using any special purpose software. By the very nature of the JAVA code, therefore, the applet can be run from any browser, even over a low bandwidth modem connection.
Seating Orthosis Design fop Prevention of Decubitus Ulcers

Decubitus ulcers can lead to very serious medical consequences for nonambulatory people who have impaired sensation. Associated medical treatment can be extremely expensive. Factors contributing to the formation of ulcers are discussed. Seating orthosis design characteristics that can reduce ulcer-generating factors are presented. Particular attention is given to design features and custom fabrication techniques related to redistributing pressure away from at-risk locations and to minimizing shear.
Protein resistant oligo(ethylene glycol) terminated self-assembled monolayers of thiols on gold by vapor deposition in vacuum

Protein resistant oligo(ethylene glycol) (OEG) terminated self-assembled monolayers SAMs) of thiols on gold are commonly used for suppression of nonspecific protein adsorption in biology and biotechnology. The standard preparation for these SAMs is the solution method (SM) that involves immersion of the gold surface in an OEG solution. Here the authors present the preparation of 11-(mercaptoundecyl)-triethylene glycol [HS(CH2)11(OCH2CH2)3OH] SAMs on gold surface by vapor deposition (VD) in vacuum. They compare the properties of SAMs prepared by VD and SM using x-ray photoelectron spectroscopy (XPS), polarization modulation infrared reflection absorption spectroscopy, and surface plasmon resonance measurements. VD and SM SAMs exhibit similar packing density and show a similar resistance to the nonspecific adsorption of various proteins bovine serum albumin, trypsin, and myoglobin) under physiological conditions. A very high sensitivity of the OEG SAMs to x-ray radiation is found, which allows tuning their protein resistance. These results show a new path to in situ engineering, analysis, and patterning of protein resistant OEG SAMs by high vacuum and ultrahigh vacuum techniques.
Low thermodynamic but high kinetic stability of an antifreeze protein from Rhagium mordax

The equilibrium heat stability and the kinetic heat tolerance of a recombinant antifreeze protein (AFP) from the beetle Rhagium mordax (RmAFP1) are studied through differential scanning calorimetry and circular dichroism spectroscopy. In contrast to other insect AFPs studied with this respect, the RmAFP1 has only one disulfide bridge. The melting temperature, Tm, of the protein is determined to be 28.5°C (pH 7.4), which is much lower than most of those reported for AFPs or globular proteins in general. Despite its low melting temperature, both biophysical and activity measurements show that the protein almost completely refolds into the native state after repeated exposure of 70°C. RmAFP1 thus appears to be kinetically stable even far above its melting temperature. Thermodynamically, the insect AFPs seem to be dividable in three groups, relating to their content of disulfide bridges and widths of the ice binding motifs; high melting temperature AFPs (high disulfide content, TxT motifs), low melting temperature but high refolding capability AFPs (one disulfide bridge, TxTxTxT motifs) and irreversibly unfolded AFPs at low temperatures (no disulfide bridges, TxTxTxTxT motifs). The property of being able to cope with high temperature exposures may appear peculiar for proteins which strictly have their effect at subzero temperatures. Different aspects of this are discussed.
Examining the Added Value of Audio, Graphics, and Interactivity in an Internet Intervention for Pediatric Encopresis

A growing number of Web sites provide personalized health interventions using the technological advances afforded by the Internet. It is critical to determine how to best develop these applications to obtain positive outcomes. Several small studies are presented here to determine whether 3 Web components-audio, graphics, and interactivity-should be incorporated. Forty-nine children and their parents presenting to a pediatric gastroenterology clinic for treatment of encopresis participated. They were shown modules of an encopresis Internet intervention both with and without the study components to examine pre to post changes in knowledge, motivation, and readiness to change. Multivariate analyses indicated highly significant pre-post effects for each of the 3 components. To our knowledge, this is the first time specific Web-based components of an Internet intervention were empirically evaluated to determine incorporation in the development of an online treatment program.
Chemical cross‐linking and mass spectrometry to determine the subunit interaction network in a recombinant human SAGA HAT subcomplex

Understanding the way how proteins interact with each other to form transient or stable protein complexes is a key aspect in structural biology. In this study, we combined chemical cross‐linking with mass spectrometry to determine the binding stoichiometry and map the protein–protein interaction network of a human SAGA HAT subcomplex. MALDI‐MS equipped with high mass detection was used to follow the cross‐linking reaction using bis[sulfosuccinimidyl] suberate (BS3) and confirm the heterotetrameric stoichiometry of the specific stabilized subcomplex. Cross‐linking with isotopically labeled BS3 d0‐d4 followed by trypsin digestion allowed the identification of intra‐ and intercross‐linked peptides using two dedicated search engines: pLink and xQuest. The identified interlinked peptides suggest a strong network of interaction between GCN5, ADA2B and ADA3 subunits; SGF29 is interacting with GCN5 and ADA3 but not with ADA2B. These restraint data were combined to molecular modeling and a low‐resolution interacting model for the human SAGA HAT subcomplex could be proposed, illustrating the potential of an integrative strategy using cross‐linking and mass spectrometry for addressing the structural architecture of multiprotein complexes.
Performance of a spread spectrum packet radio network link in a Poisson field of interferers

Results on the modeling of interference in a radio communication network and performance measures for the link as a function of distance are presented. It is assumed that a transmitter-receiver pair in a radio network is affected by a set of interferers, using the same modulation and power, whose positions are modeled as a Poisson field in the plane. Assuming a 1/r/sup gamma / propagation power loss law, the probability distributions for the noise at the receiver are found to be the stable distributions. Results are given for the probability of symbol error and link capacity as a function of the distance between the transmitter and receiver for direct sequence and frequency hopping spread spectrum schemes. It is found that the frequency hopping schemes are inherently superior and their performance is not dependent on the synchronization of the hopping times for the different users. >