Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutrient Composition and Fatty Acid and Protein Profiles of Selected Fish By-Products

Processing of fish in aquaculture generates considerable amounts of by-products that remain underused and/or unexploited. We evaluated the nutritive content of fish by-products (head, gills, intestines, trimmings, bones, and skin) from meagre and gilthead sea bream fish species reared in Greece in order to estimate their nutritional value for future development of high added-value products. The proximate composition of the fish samples (total protein, total lipid, ash, moisture, and macro-element content) was determined using the Association of Official Analytical Chemists (AOAC) and International Organization for Standardization (ISO) official methods. The content of fatty acids was determined using capillary gas chromatography, and the protein profile was estimated employing scientific orbitrap mass spectrophotometer methodology. The nutrient composition of fish by-products presented fluctuations among the different by-products. Skin was the most significant protein source, trimmings and bones were high in calcium, and the head, intestines, and bones were a good source of lipids. The most abundant lipid acids found in by-products were oleic, palmitic, linoleic, and eicosenoic acids, whereas the most abundant proteins were adenosine triphosphate (ATP) synthase subunit epsilon, mitochondrial nicotinamide adenine dinucleotide (NADH) dehydrogenase, and mitochondrial cytochrome b-c1 complex subunit 8. These data suggest that by-products constitute valuable sources of nutrients and could therefore be exploited in accordance with the principles of a circular economy.
A Systematic Review on the Implications of O-linked Glycan Branching and Truncating Enzymes on Cancer Progression and Metastasis

Glycosylation is the most commonly occurring post-translational modifications, and is believed to modify over 50% of all proteins. The process of glycan modification is directed by different glycosyltransferases, depending on the cell in which it is expressed. These small carbohydrate molecules consist of multiple glycan families that facilitate cell–cell interactions, protein interactions, and downstream signaling. An alteration of several types of O-glycan core structures have been implicated in multiple cancers, largely due to differential glycosyltransferase expression or activity. Consequently, aberrant O-linked glycosylation has been extensively demonstrated to affect biological function and protein integrity that directly result in cancer growth and progression of several diseases. Herein, we provide a comprehensive review of several initiating enzymes involved in the synthesis of O-linked glycosylation that significantly contribute to a number of different cancers.
A novel mechanical ventilator providing flow-controlled expiration for small animals

For investigating the effects of mechanical ventilation on the respiratory system, experiments in small mammal models are used. However, conventional ventilators for small animals are usually limited to a specific ventilation mode, and in particular to passive expiration. Here, we present a computer-controlled research ventilator for small animals which provides conventional mechanical ventilation as well as new type ventilation profiles. Typical profiles of conventional mechanical ventilation, as well as flow-controlled expiration and sinusoidal ventilation profiles can be generated with our new ventilator. Flow control during expiration reduced the expiratory peak flow rate by 73% and increased the mean airway pressure by up to 1 mbar compared with conventional ventilation without increasing peak pressure and end-expiratory pressure. Our new ventilator for small animals allows for the application of various ventilation profiles. We could analyse the effects of applying conventional ventilation profiles, pressure-controlled ventilation and volume-controlled ventilation, as well as the novel flow-controlled ventilation profile. This new approach enables studying the mechanical properties of the respiratory system with an increased freedom for choosing independent ventilation parameters.
Hospital wastewater as hotspots for pathogenic microorganisms spread into aquatic environment: A review

Combined with human-to-human contact, the potential for SARS-CoV-2 virus transmission via aerosols and feces raises the urgency for effective treatment of hospital wastewater (HWW), which has been assumed as an important source of pathogenic microorganisms spreading into aquatic environments. However, there are few reviews discussing the presence and removal of pathogens in hospital wastewaters matrices. This review summarizes the pathogenic microorganisms including bacteria, fungi, viruses and parasites present in hospital wastewater, the related diseases and treatment processes. In addition, the removal of pathogens during hospital wastewater treatment process is reviewed, including the preliminary process, secondary process and tertiary process. Due to the growing concerns over the effects of the current global pandemic on hospital wastewater treatment process, further research is necessary to investigate the actual fate of pathogens in hospital wastewater and optimize disinfection processes. Graphical Abstract
Survival after Kidney Transplantation during Childhood and Adolescence.

BACKGROUND AND OBJECTIVES Survival in pediatric kidney transplant recipients has improved over the past five decades, but changes in cause-specific mortality remain uncertain. The aim of this retrospective cohort study was to estimate the associations between transplant era and overall and cause-specific mortality for child and adolescent recipients of kidney transplants. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Data were obtained on all children and adolescents (aged <20 years) who received their first kidney transplant from 1970 to 2015 from the Australian and New Zealand Dialysis and Transplant Registry. Mortality rates were compared across eras using Cox regression, adjusted for confounders. RESULTS A total of 1810 recipients (median age at transplantation 14 years, 58% male, 52% living donor) were followed for a median of 13.4 years. Of these, 431 (24%) died, 174 (40%) from cardiovascular causes, 74 (17%) from infection, 50 (12%) from cancer, and 133 (31%) from other causes. Survival rates improved over time, with 5-year survival rising from 85% for those first transplanted in 1970-1985 (95% confidence interval [95% CI], 81% to 88%) to 99% in 2005-2015 (95% CI, 98% to 100%). This was primarily because of reductions in deaths from cardiovascular causes (adjusted hazard ratio [aHR], 0.25; 95% CI, 0.08 to 0.68) and infections (aHR, 0.16; 95% CI, 0.04 to 0.70; both for 2005-2015 compared with 1970-1985). Compared with patients transplanted 1970-1985, mortality risk was 72% lower among those transplanted 2005-2015 (aHR, 0.28; 95% CI, 0.18 to 0.69), after adjusting for potential confounders. CONCLUSIONS Survival after pediatric kidney transplantation has improved considerably over the past four decades, predominantly because of marked reductions in cardiovascular- and infection-related deaths.
Photoemission from Free Particles and Droplets.

Intriguing properties of photoemission from free, unsupported particles and droplets were predicted nearly 50 years ago, though experiments were a technical challenge. The last few decades have seen a surge of research in the field, due to advances in aerosol technology (generation, characterization, and transfer into vacuum), the development of photoelectron imaging spectrometers, and advances in vacuum ultraviolet and ultrafast light sources. Particles and droplets offer several advantages for photoemission studies. For example, photoemission spectra are dependent on the particle's size, shape, and composition, providing a wealth of information that allows for the retrieval of genuine electronic properties of condensed phase. In this review, with a focus on submicrometer-sized, dielectric particles and droplets, we explain the utility of photoemission from such systems, summarize several applications from the literature, and present some thoughts on future research directions. Expected final online publication date for the Annual Review of Physical Chemistry, Volume 71 is April 20, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Characterization of Adenovirus 5 E1A Exon 1 Deletion Mutants in the Viral Replicative Cycle

Human adenovirus infection is driven by Early region 1A (E1A) proteins, which are the first proteins expressed following the delivery of the viral genome to the cellular nucleus. E1A is responsible for reprogramming the infected cell to support virus replication alongside the activation of expression of all viral transcriptional units during the course of the infection. Although E1A has been extensively studied, most of these studies have focused on understanding the conserved region functions outside of a full infection. Here, we investigated the effects of small deletions in E1A exon 1 on the viral replicative cycle. Almost all deletions were found to have a negative impact on viral replication with the exception of one deletion found in the mutant dl1106, which replicated better than the wild-type E1A expressing dl309. In addition to growth, we assessed the virus mutants for genome replication, induction of the cytopathic effect, gene and protein expression, sub-cellular localization of E1A mutant proteins, induction of cellular S-phase, and activation of S-phase specific cellular genes. Importantly, our study found that virus replication is likely limited by host-specific factors, rather than specific viral aspects such as the ability to replicate genomes or express late proteins, after a certain level of these has been expressed. Furthermore, we show that mutants outside of the conserved regions have significant influence on viral fitness. Overall, our study is the first comprehensive evaluation of the dl1100 series of exon 1 E1A deletion mutants in viral fitness and provides important insights into the contribution that E1A makes to viral replication in normal human cells.
The Effect of Tenofovir Disoproxil Fumarate on Bone Mineral Density: A Systematic Review and Meta-Analysis

Background We conducted a systematic review and meta-analysis (CRD#42017070552) to quantify the impact of oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) on bone mineral density (BMD) and the risk of osteoporosis, low bone mass and fractures, among people taking it as pre-exposure prophylaxis (PrEP), HIV treatment and HBV treatment. Methods We searched MEDLINE and EMBASE for randomized controlled trials published from 1997–2018 reporting BMD, osteoporosis, low bone mass and/or fractures in treatment-naive patients taking compared with not taking TDF for 48 ±4 weeks. We pooled outcomes using DerSimonian random-effects models. Results Our search yielded 5,178 abstracts, representing 3,865 articles, with 25 meeting the inclusion criteria. TDF was associated with greater BMD decline when taken as PrEP (lumbar spine: mean difference [MD]=-0.82%, 95% CI=-1.28, -0.37%, I2=38%; total hip: MD=-0.81%, 95% CI=-1.22, -0.40%, I2=48%) and HIV treatment (lumbar spine: MD=-1.62%, 95% CI=-2.30, -0.95%, I2=93%; total hip: MD=-1.75%, 95% CI=-2.08, -1.42%, I2=83%; femoral neck: MD=-1.26%, 95% CI=-2.15, -0.38%, I2=43%) in comparison to those not taking TDF. Eight studies reported on incident osteoporosis or low bone mass, with variable results. Pooled results from five PrEP studies showed that TDF was not associated with increased fractures compared with no PrEP (RR=1.12, 95% CI=0.752, 1.74, I2=26%). Conclusions TDF caused greater decreases in BMD than did comparators when used for all three indications and the magnitude of this decrease was larger for HIV treatment compared with PrEP. Fractures were not increased among PrEP patients. The clinically significant BMD decline caused by TDF and current expansion of PrEP use suggest attention to the adverse bone effects of TDF will increase in importance.
Analysis of Efficient Wavelet Based Volumetric Image Compression

Recently, the wavelet transform has emerged as a cutting edge technology, within the field of image compression research. Telemedicine, among other things, involves storage and transmission of medical images, popularly known as Teleradiology. Due to constraints on bandwidth and storage capacity, a medical image may be needed to be compressed before transmission/storage. This paper is focused on selecting the most appropriate wavelet transform for a given type of medical image compression. In this paper we have analyzed the behavior of different type of wavelet transforms with different type of medical images and identified the most appropriate wavelet transform that can perform optimum compression for a given type of medical imaging. To analyze the performance of the wavelet transform with the medical images at constant PSNR, we calculated SSIM and their respective percentage compression.
Jeevan Rekha: Counter for Hepatitis C in Haryana

Aims and Objectives: To Study the effectivity of state sponsored scheme i.e. Jeevan Rekha in combating the menace of chronic hepatitis C in haryana. Introduction: Hepatitis C is a contagious liver disease that results from infection with the hepatitis C virus. Progression from acute to chronic HCV infection occurs in 50% to 85% of cases. Hepatitis C virus (HCV) is a major cause of liver disease worldwide and a potential cause of substantial morbidity and mortality in the future. Materials and Methods: The patients who were found to be having anti-HCV positive, during evaluation at screening camps, blood donation camps, Pre-anesthetic checkup for various surgeries or incidental detection and subsequently confirmed on HCV RNA quantitative and genotyping were treated with Pegylated Interferon and Ribavarin and followed serially with viral loads at repeatedly intervals, till they reached stage of sustained virological response. Results: Majority of the subjects were male and belonged to younger age group. Genotype 3 was most common, followed by 4 and 1. The compliance rate was excellent i.e.93%. The overall sustained virological response was very high i.e.90%.
Research on android infiltration technology based on the silent installation of an accessibility service

This work focuses mainly on the penetration test function and stability of Android smartphones under Kali 2019 and creates a stable penetration function of Android smartphones to form a strong reverse transmission control protocol connection. Using the silent installation technology supported by the Accessibility Service (integrated on a nontoxic functional platform), the Android Package that injects the penetration function successfully bypasses the common mobile phone antivirus software on the market to improve the penetration efficiency.
Differentially Private Automatic Differentiation Variational Inference (DP-ADVI) (Extended Abstract)

Many machine learning applications are based on data collected from people, such as their tastes and behaviour as well as biological traits and genetic data. Regardless of how important the application might be, one has to make sure individuals’ identities or the privacy of the data are not compromised in the analysis. Differential privacy constitutes a powerful framework that prevents breaching of data subject privacy from the output of a computation. Differentially private versions of many important machine learning methods have been proposed, but there is a lack of an efficient unified approach applicable to arbitrary models. In this contribution, we propose a differentially private variational inference method with a very wide applicability. It is built on top of automatic differentiation variational inference (ADVI), a recent advancement which provides a variational solution to a large class of models. We add differential privacy into ADVI by clipping and perturbing the gradients. The algorithm is made more efficient through privacy amplification from subsampling. We explore the effect of different parameter combinations in logistic regression problems where the method can reach an accuracy close to non-private level under reasonably strong privacy guarantees.
Marketing Strategy Model of the Construction Consulting Service in South Kalimantan

The general public of service users have not understood about the value of construction consultancy services. This hampers marketing opportunities in the private sector for construction consulting services particularly, in South Kalimantan. The objective of the research is to create an appropriate marketing strategy for corporation construction consultancy services in South Kalimantan. It can be identified by SWOT analysis, AHP analysis, and Importance Performance-Analysis. This research is done by giving the questionnaire to the service users and construction consulting firms in South Kalimantan. The result of its are, a model of the marketing strategy of the construction consulting service, Strength-Opportunity strategy, grow and build it, service pricing strategy, and basic strategy. This model is a collaboration between the marketing-mix and service quality.
Comparison of MANET Routing Protocols in Different Traffic and Mobility Models

Routing protocol election in MANET (Mobile Ad Hoc Network) is a great challenge, because of its frequent topology changes and routing overhead. This paper compares performances of three routing protocols: Destination Sequenced Distance Vector (DSDV), Ad Hoc Ondemand Distance Vector (AODV) and Dynamic Source Routing (DSR), based on results analysis obtained using simulations with different load and mobility scenarios performed with Network Simulator version 2 (NS-2). In low load and low mobility scenarios routing protocols perform in a similar manner. However, with mobility and load increasing DSR outperforms AODV and DSDV protocols.
Poster: Training GANs to Generate Adversarial Examples Against Malware Classification

Detecting new malware using machine learning has been increasingly used lately, yet recent research has proven that deep neural networks report unexpected behavior when confronted with adversarial examples. Implementing Generative Adversarial Network (GAN) has proved to be a powerful technique in the image processing domain and it can be similarly extended to further domains such as malware evasion. While the concept is fairly straight forward for image processing, manipulating portable executable (PE) files can be challenging given its binary nature and the fact that perturbations can render the file corrupt. Hence, most of research proposed in the literature work with limited malware representations and dismissed the actual files. Our hypothesis is that generating valid PE files can be more effective for adversarial learning and the use of machine learning for malware classification. Therefore, we designed an approach using GAN to generate malware adversarial examples by injecting byte-level perturbations, which are able to bypass state-of-the-art classifiers.
VALIDATION AND CHARACTERIZATION OF A HEART FAILURE ANIMAL MODEL

The major objective of the present study was to induce left ventricular hypertrophy (LVH) and subsequently heart failure (HF) by aortic banding in rats. Furthermore, with the use of different markers, we aimed to validate an animal model and to characterize the evolution of the cardiac function from normal to LVH and to HF. We used two study groups: abdominal aortic banding (AAB) (n = 20) and sham (n = 10), four echocardiography time-points (baseline, 8, 18 and 24 weeks postoperation PO) and two plasma and tissue analysis time-points (18 and 24 weeks PO). Echocardiography parameters such as LVH parameters (heart weight-to-body weight ratio, LV mass, LV mass-index, anterior, posterior and relative wall thickness), LV dimension parameters, LV performance parameters (fractional shortening FS%; ejection fraction EF%), histopathology, as well as plasmatic markers such as malondyaldehyde and superoxide dismutase can be used to distinguish between LVH and HF in this animal model. The validated animal model can be used to study the pharmacology of drugs that may prevent or treat LVH and HF.
Safe Use of Repeated Injection of 50nm Gold Nanorods on Reproductive Function in Male Albinorats: Histological, Morphometric, Hormonal and Oxidative Stress Parameters

Gold nanoparticle have received a great focus todays. In this study, we investigated the effect of repeated administration of gold nanorods (AuNRs) on testicular function, sexual hormones and oxidative stress parameters. Twenty adult male albino rats were allocated into two equal groups each of ten rats. The first group received 1ml/kg saline I.P and the second group received 7. 5μg/kg of AuNRs (50nm) I.P five consecutive days every month for two months. At the end of the second month, all rats from both groupswere sacrificed. Histopathological examination revealed no histopathological or morphometrical changes in testis,epididymis and seminal vecicle of AuNRs injected male rats. AuNRswere not detected by transmission electron microscope. Biochemical results detected that serum total and free testosterone significantly increased in AuNRs treated group in comparison with control group. Luteinizing hormone significantly decreased. Follicle stimulating hormone significantly increased. Cortisol hormone significantly decreased. Malondialdehyde significantly decreased while antioxidant enzyme as catalase, Glutathione peroxidase and superoxide dismutase were significantly increased in AuNRs in comparison with control group.We conclude that repeatedi.pinjecton of 7. 5μg/kg 50 nmAuNRs five consecutive days each month for two months has not any testicular toxicity as well as it show antioxidant activity.
CHARACTERIZATION OF BACILLUS BIOFERTILIZER “KIKUSHI” FOR PADDY RICE

We havedeveloped Bacillus biofertilizer “Kikuichi” for paddy rice. This biofertilizer is a granule type, and spores of Bacillus pumilus TUAT1 are absorbed by the granule having base material of zeolite and diatomite. Size of granule is around 3 mm and 10 spores which is kept in one gram of granules. Quality of this biofertilizer can survive around one year at room temperature. When Bacillus biofertilizer “Kikuichi” is applied to rice seeds in nursery boxes, the seedlings show over 30% increase in root growth such as root number and root weight of rice seedling against the control plants without “Kikuichi”. When the rice plants with “Kikuichi”are transplanted to paddy fields, root growth is can be seen in paddy fields and this promotes nitrogen fertilizer uptake. These inoculation effects induce an increase of tillers of treated rice plants, therefore, application of “Kikuichi” increase yields of brown rice at 10% to 30%. Rice plants with applied “Kikuichi” promotes an efficiency of fertilizer utilization in order to develop root systems, therefore this property directly connects to reduce amounts of fertilizer application.