Miracle-dz/UniFAR-FTUs huggingface dataset:
Cell‐surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus

Airway MΦ and DCs are important components of innate host defense and can play a critical role in limiting the severity of influenza virus infection. Although it has been well established that cell‐surface SA acts as a primary attachment receptor for IAV, the particular receptor(s) or coreceptor(s) that mediate IAV entry into any cell, including MΦ and DC, have not been clearly defined. Identifying which receptors are involved in attachment and entry of IAV into immune cells may have important implications in regard to understanding IAV tropism and pathogenesis. Recent evidence suggests that specialized receptors on MΦ and DCs, namely CLRs, can act as capture and/or entry receptors for many viral pathogens, including IAV. Herein, we review the early stages of infection of MΦ and DC by IAV. Specifically, we examine the potential role of CLRs expressed on MΦ and DC to act as attachment and/or entry receptors for IAV.
Anthroposophic Supportive Treatment in Children With Medulloblastoma Receiving First-line Therapy

Background The use of anthroposophic medicine (AM) is popular in Central Europe, especially in German-speaking countries. Although these therapies are judged to be beneficial by many patients, there are few data with regard to the safety and efficacy in pediatric oncology. Several theoretical concerns have been published with regard to tumor enhancement or promotion of metastatic dissemination due to mistletoe. To test the indirect safety of supportive anthroposophic treatment accompanying the first-line treatment in children with medulloblastoma in this respect we performed a retrospective matched-pair analysis of patients with medulloblastoma treated by standard first-line radiochemotherapy with or without a concomitantly applied panel of AM including mistletoe. The question was whether the effectiveness of the first-line therapy is altered by AM. Procedure Seventeen patients with AM were matched in a 1:2 ratio with 34 patients from the database of the German HIT study group with regard to the criteria of diagnosis, age, status of metastatic dissemination, resection status, and first-line therapy. Results The overall survival after 10 years was 58.33% for the AM group and 57.14% for the control group, that is, showing no statistically significant difference (stratified Cox regression; P=0.6023). Event-free survival (including metastases) also did not differ between the groups (stratified Cox regression; P=0.4275). Conclusions AM consisting of different combinations of specific pharmacologic and nonpharmacologic interventions seems to be safe with respect to any potential negative impact on the first-line therapy. There is no evidence with regard to tumor enhancement. The effectiveness of the supportive AM cannot be assessed on the basis of these data.
Cellular prion protein transduces neuroprotective signals

To test for a role for the cellular prion protein (PrPc) in cell death, we used a PrPc‐binding peptide. Retinal explants from neonatal rats or mice were kept in vitro for 24 h, and anisomycin (ANI) was used to induce apoptosis. The peptide activated both cAMP/protein kinase A (PKA) and Erk pathways, and partially prevented cell death induced by ANI in explants from wild‐type rodents, but not from PrPc‐null mice. Neuroprotection was abolished by treatment with phosphatidylinositol‐specific phospholipase C, with human peptide 106–126, with certain antibodies to PrPc or with a PKA inhibitor, but not with a MEK/Erk inhibitor. In contrast, antibodies to PrPc that increased cAMP also induced neuroprotection. Thus, engagement of PrPc transduces neuroprotective signals through a cAMP/PKA‐dependent pathway. PrPc may function as a trophic receptor, the activation of which leads to a neuroprotective state.
Structural insights into membrane fusion at the endoplasmic reticulum

The endoplasmic reticulum (ER) in eukaryotes is composed of an interconnected network of membrane tubules that undergoes permanent membrane fusion and fission. A hallmark of this membrane system is the presence of so-called three-way junctions (Fig. 1). These connections between adjacent membrane tubules are essential for the continuity of the ER luminal space. In 2009, two groups identified the ER resident atlastin GTPases as key players involved in the maintenance of normal ER morphology (1, 2). Whereas down-regulation of atlastin function in Drosophila motor neurons resulted in shorter and unconnected ER tubules (1), interference with atlastin function in humans and yeast resulted in long unbranched ER tubules (2). Furthermore, purified atlastin was shown to catalyze membrane fusion in a GTPase-dependent fashion (1) and interact with proteins from the reticulon and deleted in polyposis 1 (DP1) families (2), which are also involved in maintaining ER shape (3). The work by Byrnes and Sondermann (4) in PNAS now sheds light on the structural basis of how atlastins perform this function.
Scanning confocal optical microscopy and magnetic resonance on single defect centers

The fluorescence of individual nitrogen-vacancy defect centers in diamond was observed with room-temperature scanning confocal optical microscopy. The centers were photostable, showing no detectable change in their fluorescence emission spectrum as a function of time. Magnetic resonance on single centers at room temperature was shown to be feasible. The magnetic resonance spectra revealed marked changes in zero-field splitting parameters among different centers. These changes were attributed to strain-induced differences in the symmetry of the centers.
Mortalidad en pacientes con enfermedad renal. Instituto de Nefrología. 2016 y 2017

Introduction: Chronic kidney disease is a health problem worldwide. Objective: To determine the behavior of mortality in patients with kidney damage in the Nephrology Institute during the years between 2016 and 2017. Material and Method: A cross-sectional descriptive observational study was conducted in 48 deceased patients who underwent necropsy. Demographic and laboratory variables were recorded, as well as those related to the type of renal function replacement therapy and the anatomopathological diagnosis. Absolute and relative frequencies were calculated for each of the variables. In the case of the variable "presence of sepsis" in deaths, the Chi-Square Goodness-of-Fit Test was used to test the Null Hypothesis HO: uniformity of the distribution of the three categories of the variable. Results: A total of 48 deceased were studied at necropsy, representing 48.9% of the total number of deaths within the period. The clinical- pathological correlation was 80.1%. The male sex, the group over the age of 60 years, and arterial hypertension as antecedent of the disease predominated in the study. The most documented method of renal function replacement therapy was hemodialysis which was performed through central venous catheter, 87.8%. The 61.8% of deceased patients received hemodialysis treatment for 3 months or less. Sepsis represented the second cause of death preceded by cardiovascular and cerebrovascular events. However, during the analysis of all the necropsies, the direct or indirect infection associated with the death had a greater frequency. Conclusions: Direct or indirect infections associated with death, hypoalbuminemia, and the vascular access with venous catheter was related to mortality during the observed period. Keywords: mortality, chronic kidney disease, hemodialysis, vascular access, infections.
Phosphate binders: New products and challenges

Optimal phosphate control in dialysis patients is extremely challenging. A growing awareness of the deleterious effect of mineral metabolism imbalances together with the lack of a satisfactory explanation for the exaggerated mortality rate in patients undergoing renal replacement therapy has led to a renewed effort to refine our approach to hyperphosphatemia. However, despite the remarkable improvements in dialysis techniques, phosphate control has not substantially improved. Achieving normo‐phosphatemia presents a multitude of practical and scientific challenges related to the optimal target level, cardiovascular health, and drug toxicities. It is the aim of the present review to summarize briefly the controversies associated with currently available phosphate binders, a cornerstone in the current management of hyperphosphatemia.
High frequency electro-optic measurement of strained silicon racetrack resonators

In this paper, we report on time resolved electro-optic measurements in strained silicon resonators. Strain is induced by applying a mechanical deformation to the device. It is demonstrated that the linear electro-optic effect vanishes when the applied voltage modulation varies much faster than the free carrier lifetime, and that this occurs independently on the level of the applied stress. This demonstrates that, at frequencies which lie below the free carrier recombination rate, the electro-optic modulation is caused by plasma carrier dispersion. After normalizing out free carrier effects, it is found an upper limit of (8 ± 3) pm/V to the value of the strain induced χ(2)eff, zzz tensor component. This is an order of magnitude lower than the previously reported values for static electro-optic measurements.
Ultra-sensitive long period fiber gratings for broadband modulators and sensors

We demonstrate long-period gratings whose attenuation can be changed by 25 dB in a 48-nm spectral band, with ambient index changes of only 2.7/spl times/10/sup -4/. This is achieved by inducing coupling to ultra sensitive cladding modes in engineered fiber waveguides.
Mycobacterium tuberculosis Beijing Genotype and Mycobacterial Interspersed Repetitive Unit Typing

Rao et al. ([3][1]) described a method to identify Mycobacterium tuberculosis strains of the Beijing genotype. The authors suggested using simple PCR of mycobacterial interspersed repetitive unit-variable-number tandem repeat (MIRU-VNTR) locus 26 to identify these strains. This suggestion is based
Co-translational Degradation of Apolipoprotein B100 by the Proteasome Is Prevented by Microsomal Triglyceride Transfer Protein

We studied the effect of inhibition of microsomal triglyceride transfer protein (MTP) on apolipoprotein (apo) B100 translation and secretion using HepG2 cells. The MTP-mediated lipid transfer activity was reduced using a specific MTP inhibitor. ApoB100 translation was synchronized by treatment with puromycin prior tol-[35S]methionine pulse-chase labeling. During the first 4 min of chase, synthesis of apoB polypeptides the size of 100–200 kDa was insensitive to the inhibitor, suggesting that inhibition of MTP did not affect the initiation of apoB100 translation. After 15 min of chase, the 100–200-kDa species were chased into polypeptides larger than 320 kDa (i.e. apoB65 or 65% of full-length apoB100) in both control and inhibitor-treated cells. However, the amount of these polypeptides decreased (by 36% for apoB65-75, by 64% for apoB75-85, by 76% for apoB85-95, and by 77% for apoB100) upon MTP inhibition. No accumulation of smaller polypeptides was observed, but total immunoprecipitable apoB radioactivity was decreased suggesting that apoB could undergo co-translational degradation when MTP activity was reduced. Inhibitors of the multicatalytic proteinase complex (proteasome) such as lactacystin or MG-115 could prevent apoB co-translational degradation. Nevertheless, MG-115 could not avoid the MTP inhibitor decreasing apoB100 secretion but rather induced the accumulation of secretion-incompetent apoB100 in the cell. These results indicate that MTP activity is required during the elongation of apoB100 polypeptides, particularly at the sequences downstream of carboxyl terminus of apoB65. Co-translational degradation might constitute a more general mechanism of early quality control for large or complex proteins.
Taxonomy augmented object recognition

Realistic scene object recognition in computer vision still faces great challenges due to the large intra-class variation of object images caused by factors like object appearance variation and viewpoint change. To address this challenge, we propose to exploit the semantic relationships embedded in object taxonomy for improved object recognition. Specifically, we exploit the relationships in the object taxonomy to augment the learning of object classifiers. We utilize two types of relationships in the taxonomy, including the overall relationship and the local relationship. Our proposed approach jointly incorporates both the overall relationship as the loss function for classifier learning, and the local relationship as classifier learning constraints. Experiments on benchmark datasets demonstrate the effectiveness of our method in incorporating taxonomy for object recognition compared to the state-art-the-art methods.
Accuracy of MRI in prediction of pathologic complete remission in breast cancer after preoperative therapy: a meta-analysis.

OBJECTIVE Prediction of pathologic complete remission in breast cancer after preoperative therapy presents difficulties. We performed a meta-analysis to determine the ability of MRI to predict pathologic complete remission in patients with breast cancer after preoperative therapy. MATERIALS AND METHODS Medical subject heading terms ("MRI" and "Breast Neoplasm") and key words ("neoadjuvant" or "primary systemic" or "preoperative" or "presurgery") were used for a literature search in the MEDLINE database. A meta-analysis of pooled data from eligible studies was performed to estimate the accuracy of MRI in predicting pathologic complete remission after preoperative therapy in patients with breast cancer. RESULTS Twenty-five studies were included in this meta-analysis. Pooled weighted estimates of sensitivity and specificity were 0.63 (range, 0.56-0.70) and 0.91 (range, 90.89-0.92), respectively. Heterogeneity between studies was highly influenced by the pathologic complete remission rate, with a regression coefficient of -6.160 (p = 0.020). Subgroup analysis showed that the specificity of MRI in studies with a pathologic complete remission rate of > or = 20% was lower than that in studies with a pathologic complete remission rate of < 20% (p = 0.0003). CONCLUSION This meta-analysis indicates that MRI has high specificity and relatively lower sensitivity in predicting pathologic complete remission after preoperative therapy in patients with breast cancer. The pathologic complete remission rate may influence the performance of MRI accuracy in this setting, which deserves further investigation.
Efficacy and Safety of Prasugrel Compared With Clopidogrel for Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor (clopidogrel, prasugrel, or ticagrelor) is essential to prevent thrombotic complications after percutaneous coronary intervention (PCI). The comparative efficacy between clopidogrel at a higher loading dose (600 mg) and prasugrel is uncertain. The aim of this study was to compare efficacy and safety of clopidogrel (higher loading dose) with prasugrel (loading dose of 60 mg) along with their respective maintenance doses in patients with acute coronary syndrome (ACS) undergoing PCI at 1 year. This is a retrospective, observational, pilot study. Patients with ACS who underwent PCI and received clopidogrel 600 mg or prasugrel 60 mg loading dose followed by maintenance doses of 75 mg and 10 mg, respectively, daily between July 1, 2009 and June 30, 2011 were enrolled. For patients who have died during the study period, investigators attempted to identify the cause of deaths through medical records or death certificates. Two hundred twenty-one patients were enrolled in the study. Primary efficacy end point, composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke occurring through 1 year were not significantly different between the 2 treatment groups. Bleeding events were also not significant between the clopidogrel (N = 136) and prasugrel (N = 85) groups: 9.6% versus 8.2%, P = 0.85. Prasugrel is at least as effective and safe as clopidogrel in patients with ACS undergoing early invasive management.
Using simulation model to integrate production plan and dispatching system

This paper describes a SPDIS (Simulation, Production Plan and Dispatching Integration System) for linking between PMC (production management control department) and MFG (manufacturing department). First of all is the outline of this system. Then the forecast output difference between tool limitation and no tool limitation and then the shop floor control logic. In the end, it has been proved that the SPDlS not only improves the delivery rate but also reduces the argument between PMC and MFG. Implementation of the SPDIS improves CLIP by 60%. It means we have improved the delivery time and increase customer's satisfaction
A Review on Extraction and Recommendation of Educational Resources from WWW

Keyphrases give a basic method for portraying a report, giving the peruser a few pieces of information about its substance. Wrapper adjustment goes for consequently adjusting a formerly took in wrapper from the source Web webpage to another concealed website for data extraction. It depends on a generative model for the age of content parts identified with characteristic things and designing information in a Web page. To take care of the wrapper adjustment issue, we consider two sorts of data from the source Web webpage. The principal sort of data is the extraction information contained in the already took in wrapper from the source Web webpage. The second sort of data is the beforehand separated or gathered things. Utilize a Bayesian learning way to deal with naturally select an arrangement of preparing cases for adjusting a wrapper for the new concealed site. To take care of the new property revelation issue, we build up a model which breaks down the encompassing content sections of the qualities in the new inconspicuous site. A Bayesian learning strategy is produced to find the new qualities and their headers. The direct broad investigations from various genuine Web locales to show the viability of our structure. Keyphrases can be helpful in a different applications, for example, recovery motors, perusing interfaces, thesaurus development, content mining and so on. There are likewise different errands for which keyphrases are helpful.
Posttraumatic Growth and Health-related Quality of Life in a Racially Diverse Cohort of Breast Cancer Survivors

This study examined the relationship between race, religiosity, and posttraumatic growth as well as the association between growth and physical and mental health-related quality of life (HRQOL) in breast cancer survivors (N = 802; M age = 57.2). Multivariate analyses revealed that African American breast cancer survivors reported higher levels of posttraumatic growth than White women. However, this relationship was mediated by religiosity. We found an inverse association with growth and mental HRQOL which might be explained by the fact that growth co-occurs with distress and perhaps women in this sample are still struggling with their disease.
Chesapeake Bay: An Unprecedented Decline in Submerged Aquatic Vegetation

Data on the distribution and abundance of submerged aquatic vegetation in Chesapeake Bay indicate a significant reduction in all species in all sections of the bay during the last 15 to 20 years. This decline is unprecedented in the bay's recent history. The reduction in one major species, Zostera marina, may be greater than the decline that occurred during the pandemic demise of the 1930' s.
SYNTHESIS AND FORMULATION OF IBUPROFEN PRO-DRUGS FOR ENHANCED TRANSDERMAL ABSORPTION

Objectives: The aim is to synthesize ibuprofen prodrugs that have more suitable physicochemical properties and formulate them into a liquid formulation for topical administration. The transdermal delivery (TDD) is one of the most attractive routes for drug administration as it eliminates the GIT absorption variable, improves patient compliance and also reduces drug plasma fluctuations. However, TDD only drugs with suitable physico-chemical properties can be absorbed. The oral administration of NSAIDs for a long time can cause gastric mucosal damage, which may result in ulceration and bleeding. Thus, the development of a TDD of NSAIDs is of great interest as it decreases GIT side effects Methods: The synthesis of ibuprofen alkyl esters was carried out by esterification reactions with methanol, ethanol, propanol, butanol, pentanol and hexanol. The formulated samples were then subjected to stability studies according to ICH guidelines. Results: We have successfully synthesized and characterized various esters of ibuprofen. Moreover, ibuprofen butyl ester has been prepared as topical solutions. The formulated TDD was tested for stability according to ICH guidelines and the results showed no changes in the initial appearance during three months of study at room temperature & at 40 °C. Conclusion: The assay and pH were within the pharmacopeial limits during the period of the study. In conclusion, stable topical formulation of Ibuprofen esters was obtained.
Second‐generation drug‐eluting stents versus drug‐coated balloons for the treatment of coronary in‐stent restenosis: A systematic review and meta‐analysis

The benefit of drug‐eluting stents (DES) versus drug‐coated balloons (DCB) in coronary artery in‐stent restenosis (ISR) for the prevention of target lesion revascularization (TLR), stent thrombosis, and mortality remains uncertain. Our aim was to synthesize the available evidence from randomized clinical trials (RCTs) and observational studies that directly compare second‐generation drug‐eluting stents (SG‐DES) and DCB for the treatment of coronary ISR.
Defective motor control of coughing in Parkinson's disease.

The high incidence of serious chest infections in patients with Parkinson's disease is unexplained, but an impairment in cough reflex may have a role. Maximal voluntary cough (MVC) and reflex cough (RC) to inhalation of ultrasonically nebulized distilled water were analyzed in patients with Parkinson's disease and age-matched control subjects by monitoring the integrated electromyographic activity (IEMG) of abdominal muscles. The peak amplitude of IEMG activity (IEMGP) was expressed as a fraction of the highest IEMGP value observed during MVC corrected to account for possible losses in abdominal muscle force due to reduced central muscle activation. Cough intensity was indexed in terms of both the IEMGP and the ratio of IEMGP to the duration of the expiratory ramp (TEC), i.e., the rate of rise of IEMG activity. Cough threshold was slightly higher in patients than in control subjects, but the difference failed to reach statistical significance. Compared with control subjects, patients displayed a lower IEMGP during maximal expiratory pressure maneuvers (PEmax), MVC, and RC (p always < 0.01); TEC during RC was longer (p < 0.01) than in controls. Consequently, the rate of rise of IEMG activity during cough was always lower in patients (p < 0. 01), especially during RC. Finally, PEmax, and both the peak and rate of rise of IEMG activity during RC were inversely related to the level of clinical disability (Spearman rank correlation coefficient, rs = -0.88, -0.86, and -0.85, respectively, p always < 0.01). The results indicate that the central neural mechanisms subserving the recruitment of motor units and/or the increase in their frequency of discharge during voluntary and, even more markedly, RC are impaired in patients with Parkinson's disease.