Miracle-dz/UniFAR-FTUs huggingface dataset:
Stigma and Level of Dysfunction among Individual with Epilepsy

Background: In this study, we assessed the Stigma and dysfunction in the Individual with epilepsy as compared to normal control. Objective: To examine level of dysfunction of the Individual with epilepsy and normal control and to examine perceived stigma of the Individual with epilepsy and normal control. Sample: The present study conducted at Out Patient Department of Epilepsy Clinic of the Central Institute of Psychiatry, Ranchi, included 60 Individual, among which 30 Individual were diagnosed with epilepsy and 30 normal Individual as control group. Design: The present study was cross-sectional hospital based and single contact study. The study assessed the level of dysfunction and perceived stigma in the Individuals with epilepsy as compared to normal control. Tools: Socio Demographic & Clinical Data Sheet, Stigma and Dysfunction Analysis Questionnaire were used for the assessment. The Statistical Package for Social Sciences (SPPS) 16.0 for windows was used for statistical analysis. Results: Dysfunction Analysis Questionnaire revealed severe level of dysfunction in the area of social, vocational, personal, family and cognitive area and personal area' in the domain of disability analysis questionnaire in Individual with epilepsy. There were no significant differences of stigma for epilepsy in the both group. Conclusion: It can be concluded that majority of patients was male, belonging to joint family and was from rural background and result of the study revealed severe level of dysfunction in the all domain of Dysfunction Analysis Questionnaire but there was absence stigma for epilepsy in both group. Keywords: Stigma, Dysfunction, Epilepsy
Role of Ancient Ubiquitous Protein 1 in Hepatic ApoB Degradation and VLDL production

Apolipoprotein B-100 (apoB100) is the main structural protein of atherogenic lipoproteins and is a key risk factor for development of coronary heart disease. The molecular mechanisms that regulate apoB100 degradation or secretion are not clearly understood but evidence supports intracellular lipid supply as a major decisive factor. Ancient Ubiquitous Protein 1 (AUP1) has been found to be present on the surface of Lipid Droplets (LDs), and has been implicated in ER-Associated Degradation. AUP1 knockdown dramatically increased levels of cellular apoB100 and facilitated secretion of apoB100 containing VLDL-sized particles from HepG2 cells. Knocking down AUP1 also increased Triglyceride (TG) levels in apoB100 containing VLDL particles. AUP1 was found to interact with apoB100 intracellularly based on co-immunoprecipitation experiments as well as in situ proximity ligation assay. Finally, modulating AUP-1 altered LD size in HepG2 cells and its knockdown increased the average size of LDs.
Hybrid Database System for Big Data Storage and Management

Relational database systems have been the standard storage system over the last forty years. Recently, advancements in technologies have led to an exponential increase in data volume, velocity and variety beyond what relational databases can handle. Developers are turning to NoSQL which is a nonrelational database for data storage and management. Some core features of database system such as ACID have been compromised in NOSQL databases. This work proposed a hybrid database system for the storage and management of extremely voluminous data of diverse components known as big data, such that the two models are integrated in one system to eliminate the limitations of the individual systems. The system is implemented in MongoDB which is a NoSQL database and SQL. The results obtained, revealed that having these two databases in one system can enhance storage and management of big data bridging the gap between relational and NoSQL storage approach.
Improving Switching Frequency Variation of Hysteresis Current Controlled VSI Fed Induction Motor Drive

Switching frequency variation over the entire operating speed range of an induction motor (IM) drive is the major problem associated with conventional two-level threephase hysteresis controller as well as the space phasor based pulse width modulation (PWM) hysteresis controller. This paper presents a new variable band hysteresis current controller for controlling the switching frequency variation in the two-level PWM inverter fed IM drives for various operating speeds. A novel concept of online variation of the band based on both the instantaneous load current and current change for each sampling period is presented to determine the hysteresis band. A performance comparison of the proposed with conventional hysteresis current controller for IMdrive is provided in simulation. The proposed drive system is also implemented in real-time using DSP board DS1104 for a laboratory 1.5 hp motor. Comparative simulation and real-time results verify the feasibility of the proposed scheme and demonstrate that the proposed method has obtained constant switching frequency and improved the performance of the drive system.
Substituição do feno de tifton pelo feno de maniçoba na alimentação de ovinos

Objetivou-se avaliar o efeito da substituicao de feno de tifton pelo feno de manicoba sobre o consumo, digestibilidade e comportamento ingestivo em ovinos. Foram utilizados oito ovinos canulados no rumen e com peso vivo medio de 53,17 ± 8,33 kg, em delineamento quadrado latino 4 x 4. Os tratamentos consistiram na substituicao do feno do tifton por feno de manicoba nos niveis de 0,0; 33,33; 66,66 e 100%. O consumo voluntario de MS e dos nutrientes da dieta foram calculados pela diferenca entre as quantidades oferecidas e as sobras referentes ao dia anterior. Durante o periodo de coleta (1o ao 3o dia) foi avaliado o comportamento ingestivo e os ingredientes que compunham as dietas, sobras e fezes foram amostrados para avaliacao do ensaio de digestibilidade aparente. Houve efeito linear crescente (P<0,05) para os consumos de FDA, EE e CNF. As digestibilidades aparentes da FDN e da PB tiverem efeito linear decrescente a medida que se aumentou os niveis de substituicao nas dietas. O tempo de alimentacao e eficiencia de alimentacao apresentou efeito quadratico (P<0,05). A substituicao do feno de tifton por feno de manicoba em dietas para ovinos reduz a utilizacao da fibra e aumenta o tempo de ruminacao em funcao do tipo de fibra dessa forrageira.
Association resistance to metritis and resistance to mastitis in an ovine genetic model : analysis of the endometrial response after experimental infection

This project aims to evaluate if genetic susceptibility to mastitis is associated with susceptibility to metritis. The work consisted in transcriptome analyses of the two endometrial areas (aglandular caruncles –CAR- and intercaruncular gland-containing areas –ICAR-) collected from two lines of dairy sheep [LSCS] and [HSCS] that display a low and a high susceptibility to mammary infections respectively. Uteri of multiparous [LSCS] and [HSCS] cyclic ewes were infused with a solution of uterine-related pathogenic E. coli strain for 24h. [LSCS] ewes were used as a non-infected control. Total RNA profiles from CAR and ICAR samples were determined by RNA-seq.
Modelling Sea Surface Temperature (SST) in the Hudson Bay Complex Using Bulk Heat Flux Parameterization: Sensitivity to Atmospheric Forcing, and Model Resolution

ABSTRACT Sea surface temperature (SST) from four Nucleus for European Modelling of the Ocean (NEMO) model simulations is analyzed to study the bulk flux parameterization to compute SST over the Hudson Bay Complex (HBC) for the summer months (August and September) from 2002 to 2009. The NEMO simulation was forced with two atmospheric forcing sets with different resolutions: the Coordinated Ocean-ice Reference Experiment, version 2 (COREv2), as the lower resolution and the Canadian Meteorological Centre’s Global Deterministic Prediction System Reforecasts (CGRF) as the higher resolution. The CGRF forcing is also implemented in the third and fourth runs using different runoff data and different NEMO resolutions (1/12° versus 1/4°). Results show that all four modelled SSTs followed observed SST patterns, with regional differences in SST bias between simulations with different atmospheric forcing. The SST differences are small between simulations forced with the same atmospheric forcing but with different model resolution or runoff. This implies that the model resolution and runoff have a small effect on the simulated SST in the HBC. Moreover, to better capture the effect of near-surface temperature (Tair) on simulated SST, we conducted three analyses using the Haney flux linearization formula. Results from these assessments did not indicate any direct influence on the model-simulated SSTs by Tair. Looking at the heat flux as a signature for SST showed that both averaged spatial distribution and time series of net heat flux produced by the three CGRF forcing simulations were higher than the net heat flux generated by the CORE 2 simulation. This was generally true for all four components of the total heat flux (sensible, latent, shortwave, and longwave) individually as well. Total heat flux in summer is governed by the shortwave heat flux, with values up to 120 W m−2 in August, and the longwave heat flux is the main contributor to the total heat flux differences. These heat flux differences lead to corresponding colder model SSTs for the CGRF runs and warmer SSTs for the CORE 2 simulations.
The consistency and complexity
of accounting terminology in Croatian higher education system

Usually the most important role of language is to facilitate communication, which often proves challenging if the used terminology is inconsistent, complex or not understandable. These issues may especially affect specific language that is characteristic for a certain profession, particularly when the members of the profession communicate the message to the outsiders. Literature review suggests that the accounting terminology may sometimes be perceived as complex or incomprehensible, due to multiple changes and variations of accounting terms. Since there is a lack of research in the field of higher education, a research was conducted with the aim of analyzing accounting terminology used in the higher education institutions in Croatia. Both secondary and primary data were used in the analysis. The secondary data included accounting courses curricula of a sample of higher education institutions in Croatia, which were analyzed in order to explore the consistency of accounting terminology. In addition, the research was supplemented by collecting primary data using questionnaire on the attitudes of students about the complexity of accounting terminology. The analysis of accounting terms used in accounting courses curricula led to a conclusion that the analyzed courses, in most cases, are not harmonized regarding the terminology used. However, these results were expected from the previous research, that showed that the same applies for the Croatian regulatory accounting framework, which is why it was concluded that using different synonyms for the same accounting concepts may be beneficial for students. As for the students’ attitudes towards accounting terminology, the students who participated in the research mostly agree that the accounting courses often use different synonyms for the same concept. Although they perceive this as confusing, they are also aware that using multiple synonyms during courses for the same accounting concepts is useful because it serves as a preparation for practice. On the other hand, they mostly disagree with the statement that the accounting terminology is too complex and incomprehensible, which has proved to be influenced by the students’ characteristics, such as the type of study program enrolled, year of study, number of accounting courses attended, secondary school type and working experience. This research complements previous research conducted in Croatia in other areas where the accounting terminology is present, such as the legislation or in practice among business professionals, which is its main scientific contribution As for the practical implications, results of the research may serve as an indicator to educators and legislators in their future actions, since the potential problem of inconsistency and complexity of accounting terminology in courses' curricula are a direct consequence of inconsistency and complexity of terminology in accounting legislative.
Development of a confinable gene drive system in the human disease vector Aedes aegypti

Aedes aegypti, the principal mosquito vector for many arboviruses that causes yellow fever, dengue, Zika, and chikungunya, increasingly infects millions of people every year. With an escalating burden of infections and the relative failure of traditional control methods, the development of innovative control measures has become of paramount importance. The use of gene drives has recently sparked significant enthusiasm for the genetic control of mosquito populations, however no such system has been developed in Ae. aegypti. To fill this void and demonstrate efficacy in Ae. aegypti, here we develop several CRISPR-based split-gene drives for use in this vector. With cleavage rates up to 100% and transmission rates as high as 94%, mathematical models predict that these systems could spread anti-pathogen effector genes into wild Ae. aegypti populations in a safe, confinable and reversible manner appropriate for field trials and effective for controlling disease. These findings could expedite the development of effector-linked gene drives that could safely control wild populations of Ae. aegypti to combat local pathogen transmission. Significance Statement Ae. aegypti is a globally distributed arbovirus vector spreading deadly pathogens to millions of people annually. Current control methods are inadequate and therefore new technologies need to be innovated and implemented. With the aim of providing new tools for controlling this pest, here we engineered and tested several split gene drives in this species. These drives functioned at very high efficiency and may provide a tool to fill the void in controlling this vector. Taken together, our results provide compelling path forward for the feasibility of future effector-linked split-drive technologies that can contribute to the safe, sustained control and potentially the elimination of pathogens transmitted by this species.
No Drug Is Benign

along nerves, in our experience and in the current study, adenoid cystic carcinoma is the most common traveler along the perineural pathway. These tumors arise in salivary glands both major and minor as well as in the lacrimal glands. Neural connections from these areas are of obvious importance. The foramen ovale and the stylomastoid foramen are the key transit points from the parotid. The highest concentration of minor salivary glands in the body is in the posterior roof of the mouth, and adenoid cystic carcinoma frequently originates in this location. The pterygopalatine fossa becomes an extremely important landmark as shown in the current article. The anatomy of the head and neck is indeed complex. Following neural pathways through the region can be an arduous task. Demonstration of an enlarged foramen, an enhancing nerve, or an enlarged cavernous sinus is indeed ominous. The fat planes adjacent to the skull base are equally important and deserve the same understanding and scrutiny. Indeed, when searching for perineural tumor spread, as in many situations in head and neck imaging, fat is truly a friend.
Duodenal Crohn’s Disease Complicated by Pancreatitis and Common Bile Duct Obstruction

Introduction: Crohn’s disease (CD) is characterized by segmental and transmural involvement of any portion of the gastrointestinal tract from the mouth to the anus. Duodenal CD is a rare clinical entity, with the majority of the patients being symptomless – its diagnosis requires a high level of clinical suspicion. Case Presentation: We present the case of a 29-year-old male patient with a 2-month history of weight loss, epigastric pain and postprandial vomiting. He underwent upper endoscopy, which revealed a circumferential duodenal ulcer causing non-transposable luminal stenosis and was medicated with proton pump inhibitors. While awaiting gastroenterology consultation, he presented at the emergency department for sudden onset of abdominal pain with dorsal irradiation, nausea and vomiting. Laboratory tests showed anaemia and increased liver enzymes, amylase and lipase. Abdominal computed tomography showed ectasia of the common bile duct (CBD) and intrahepatic biliary tract and a small amount of gas in the main pancreatic duct associated with duodenal thickening. The case was interpreted as probable CD complicated by pancreatitis and obstruction of the CBD, and he was hospitalized under antibiotic therapy and hydrocortisone with improvement of the condition. After discharge, he underwent colonoscopy that revealed several ulcers in the ileum and magnetic resonance imaging that showed distension of the stomach with reduction of the calibre of the transition from the duodenal bulb to the second portion of the duodenum in a 10- to 15-mm extension, as well as associated dilatation of the intrahepatic bile ducts and CBD and diffuse and regular ectasia of the main pancreatic duct. Combination therapy with azathioprine and infliximab was initiated; the patient presented clinical response at 12 weeks and endoscopic/imaging remission at 9 months. Discussion/Conclusion: Hepatobiliary and pancreatic manifestations are common in CD patients involving multiple mechanisms. In this case report, we present a patient with duodenal CD complicated with pancreatitis and CBD obstruction due to distortion phenomena by duodenal stenosis, a condition that is rarely described.
How self-perceived job insecurity affects health: Evidence from an age-differentiated mediation analysis

While the detrimental health effects of self-perceived job insecurity are well documented, less is known about the mechanisms through which insecurity affects health. In this article, potential explanations for this relationship are examined separately for three age groups (18–35, 36–50, and 51–65). Mediation analyses based on the German Socio-economic Panel show an ‘immediate shock effect’ that occurs when a person becomes worried, as well as a ‘prolonged stress effect’ that sets in when job loss worries persist over a longer period. Second, the results reveal that for middle-aged workers, both effects of self-perceived job insecurity are largely explained by the following factors: perceived financial problems, feelings of stress, exhaustion, and anxiety, a perceived lack of control, and family dissatisfaction. Yet it appears that these factors do not fully explain the detrimental health effects of job insecurity among younger or older workers.
The Effect of Compensation, Education Levels, and Job Satisfaction on Organizational Commitments to Teachers of SMPN in Padang Panjang

This study aims to analyze the effect of compensation, education level and job satisfaction on organizational commitment to teachers of SMP in Padang Panjang City. This research is included in causative research with Path analysis techniques. The population in this study were all SMPN teachers in Padang Panjang City with a total sample of 132 respondents. The results of the study indicate compensation has a direct effect on organizational commitment. The level of education has a direct effect on organizational commitment. Job satisfaction has a positive and significant effect on organizational commitment. Compensation has a positive and significant effect on job satisfaction. The level of education has a positive and significant effect on job satisfaction. Compensation has a positive and significant effect on organizational commitment through job satisfaction. The level of education has a positive and significant effect on organizational commitment through job satisfaction.
LINFOMA EM HAMSTER CHINÊS (Cricetulus griseus): RELATO DE DOIS CASOS

ABSTRACT. Alencar N.X. , Bruno S.F. , Campos S.D. E. , de Queiroz G.B. , de Souza, A.M. & Macieira, D. de B. [Lymphoma on Chinese hamster (Cricetulus griseus) - Two case reports]. Linfoma em hamster chines (Cricetulus griseus): Relato de dois casos. Revista Brasileira de Medicina Veterinaria, 34(2):141-145, 2012. Departamento de Patologia e Clinica Veterinaria, Faculdade de Veterinaria, Universidade Federal Fluminense, Rua Vital Brazil Filho, 64, Niteroi, RJ 24230-360, Brasil. E-mail: nayro@vm.uff. br Lymphoma is a lymphoid neoplasia originated in solids hematopoietic organs as lymph nodes, liver and/or spleen, also called malignant lymphoma or lymphosarcoma. Neoplasias are frequently found in hamsters, and lymphoma usually responds for 8% of these tumors. Herein, we describe two cases of lymphoma diagnosed in hamsters presented to the Wildlife Animals service of Faculdade de Veterinaria, UFF, Brazil. In the first case, the animal had two subcutaneous nodules laterally on its body. This animal was limping on its left limb. After physical examination several others nodules were observed on animal’s body. In the second case an edema in the scrotum was observed. In both cases, diagnosis was reached through fine needle aspirate biopsy. In cytology examination, there was monomorphic population of large lymphocytes (lymphoblast) with moderated anisocytosis and anisokaryosis, and evident nucleoli with variable size, number and shape was noted. Because of the high incidence of tumors in hamsters, including lymphoma, it is necessary to use additional tests that in order to classify and identify them. Cytological examination is a very efficient technique for this purpose. Therefore, it is possible to guide practioneer to set the patient’s prognosis and define the best therapeutical approach.
Enhanced Recovery after Partial and Radical Nephrectomy Reduces Length of Stay, Opioid Use and Cost.

INTRODUCTION Enhanced recovery after surgery pathways are multidisciplinary, multimodal approaches to perioperative care that aim to improve patient outcomes. In this study we evaluate the outcomes of the implementation of enhanced recovery after surgery pathways in patients undergoing nephrectomy. METHODS A retrospective analysis was performed comparing patients who underwent renal surgery before vs after implementation of enhanced recovery after surgery pathways. Data analyzed included length of stay, opioid use, cost and complications before and after the enhanced recovery after surgery protocol was implemented. RESULTS There were 76 patients in the pre-enhanced recovery after surgery group and 42 in the enhanced recovery after surgery group. Median length of stay in the pre-enhanced vs enhanced recovery after surgery group was 3 days vs 2 days (p <0.005). For open procedures median length of stay was 5 days vs 2 days (p <0.001). For robotic procedures median length of stay decreased from 3 days to 2 days (p <0.001). Median length of stay was lower in the enhanced recovery after surgery group independent of age, sex, body mass index, American Society of Anesthesiologists® score and anesthesia time. Median total morphine equivalents decreased from 4 mg to 0 mg (p <0.005) while median total oxycodone went from 52.5 mg to 8.75 mg (p <0.005). Direct cost per patient decreased from $13,036 pre-enhanced recovery after surgery to $9,779 (p <0.001) in the enhanced recovery after surgery group, representing a 25% decrease. The 30-day readmission rates did not change after implementation of enhanced recovery after surgery protocol, and a National Surgical Quality Improvement Program sampling showed similar rates in complications, although this was not amenable to statistical analysis. CONCLUSIONS Enhanced recovery after surgery improves the care of patients undergoing renal surgery. It significantly decreased length of stay, opioid use and hospital cost without having a significant effect on complications.