Miracle-dz/UniFAR-FTUs huggingface dataset:
Antidepressant activity of ethanolic extract of leaves of Centella asiatica . Linn by In vivo methods.

The antidepressant activity of ethanolic extract of Centella asiatica. Linn (Umbelliferae) were studied at doses of 100mg and 200mg/kg against forced swimming test in rodents. Imipramine (30mg/kg, i.p) was selected as reference standard and it showed significant antidepressant activity in rodents. A dose dependent reduction in immobility time was observed in FST. Whereas the extract significantly increases the exploratory behaviour in mice. The finding from the present investigation indicates that extract has significant antidepressant activity as shown by its effects on different experimentally induced different models.
The Ability to Align Vision and Kinaesthesia

textabstractWe investigated the human ability to align visually and kinaesthetically perceived end positions of arm movements. We specifically looked at the spatial characteristics of movement endpoints and the responses of the visuomotor system to altered relationships between visual and kinaesthetic information. In these studies we tried to determine what spatial information is incorporated in the motor commands generated by the visuomotor system and how this spatial information is represented. The tasks and experimental setup in the present studies were designed to study three-dimensional arm movements with the above-mentioned factors in mind. The main aim of the present research was to reveal the nature of visuomotor coordination. However, the paradigm used also serves to assess the adaptability of the visuomotor system. This may have implications for ’real-life’ situations in which humans are confronted with discrepant sensory information. Discrepancies between what we feel and what we see are present in nearly all man-machine interactions, for instance, in teleoperation. Depending on the circumstances and the task at hand this may impose major demands on the operator and may lead to serious accidents. Endoscopic surgery is seen as complicated and difficult to learn. Knowledge about the way the visuomotor system is organised and the processes by which adaptation occurs may help to identify the crucial difficulties encountered when using complex tools and contribute to the development of appropriate training programs.
EFFECTS OF DIETARY N-3 HIGHLY UNSATURATED FATTY ACIDS ON GROWTH AND FATTY ACID COMPOSITION OF JUVENILE COBIA(RACHYCENTRON CANADUM)

A feeding experiment was conducted in floating sea cages(1.0m×1.5m×2.0m) to determine the requirement of juvenile cobia(Rachycentron canadum) for n-3 highly unsaturated fatty acids(n-3 HUFA). Six semi-purified diets were formulated to contain graded levels of n-3 HUFA,ranging from 0.6 to 2.11%. Juvenile fish(weighing 8.3±0.5g) were randomly divided into 18 cages of 20 fish,and fed one of 6 diets for 8 weeks.The water temperature fluctuated from 29 to 23.5℃,the salinity from 20.9 to 23.9‰,and dissolved oxygen content was approximately 7mg/L during the experimental period.No significant differences (ANOVA,p0.05) in survival were observed among dietary treatments.However, specific growth rate(SGR) was significantly(p0.05) affected by dietary n-3 HUFA.SGR significantly increased with increasing dietary n-3 HUFA from 0 to 1.24%,and reached a peak at 1.56% of n-3 HUFA.Then,SGR slightly decreased for the groups fed the diets containing higher than 1.56% of n-3 HUFA.The content of 18∶1n-9 in muscle and liver decreased,while 22∶6n-3 increased with increasing dietary n-3 HUFA.Based on SGR,the requirement for n-3 HUFA of juvenile cobia is about 1.49% of dry diet by broken-line analysis.
Optimization of Starch and Tryptone Concentrations in Medium Composition for Lipase Production by Submerged Fermentation of Rhizopus arrhizus Using Response Surface Methodology

Aims: The aim of this study is optimization of the concentrations of carbon and nitrogen sources for lipase production by Rhizopus arrhizus using response surface methodology . Study Design: For this work optimal 2 2 composite design was used for studying the optimal concentrations of corn starch and tryptone for lipase production by submerged fermentation. A series of planned experiments in three replications was carried out and a mathematical model was developed which was used to describe the process. Optimal levels of studied independent variables were calculated by using the model and the conversion rate. Place and Duration of Study: This study is a part of PhD dissertation developed in University of
The Implication of Performance Management for Potential Wage Capping: A Study of Oil and Gas Servicing Companies in River State Nigeria: 2011-2016

DOI: 10.21276/sjebm.2018. 5.8. 4 Abstract: The study focused on the implication of performance management for potential wage capping: a study of oil and gas servicing companies in River State Nigeria: 2011-2016, with reference to Petro-Scope Energy Nigeria Limited and Phoenix Energy Nigeria Limited. The specific objectives of the study were among others to; ascertain the impact of performance management and other variables on wage rate and examine the effects of performance management on employees‘ performance in Petro-Scope Energy and Phoenix Energy Nigeria Limited. The researchers made use of survey research design, primary and secondary data was used. The population of the study consists of the employees of both organisations. Multiple Regression analysis and Pearson Product Moment Correlation analysis was used to analyse the objectives. The major findings revealed a significant and positive relationship between Performance Management, Cost of Living Index, Level of Salary Payable within the Industry and Wage Rate in Petro-Scope Energy and Phoenix Energy Nigeria Limited.Also performance management have a strong positive effects on employees‘ performance in the organisations. The researchers concluded that performance management system would be inconclusive and ineffective if it does not have a corresponding impact on employees wage rate, and recommended that PetroScope Energy Nigeria Limited and Phoenix Energy Nigeria Limited should adopt performance management practices that are consistent with their organisational longterm policy which best fit their nature of work performed and the mission of their organisation. In doing this, it should maintain an alignment with employees reward system.
GROUPING DIFFERENT WHEAT VARIETIES FOR SALT TOLERANCE USING SOME BIOCHEMICAL AND PHYSIOLOGICAL INDICES

In attention to wheat importance in human nutrition and its production limitations due to salt stress, this study was conducted to evaluate and grouping 52 different wheat varieties for activities of antioxidant enzymes. Seedlings in 4-5 leaf stage, which were grown in aeroponic way, were exposed to salt stress using 200 mM NaCl for 10 days. After that, activities of enzymes of catalase, glutathione peroxidase, ascorbat dehydrogenase, superoxide dismutase isozymes along to amounts of malon dialdehyde and hydrogen peroxide, Na, K and Cl were measured. Cluster analysis categorized the varieties into three distinct groups. The varieties such as Karkheh, Arta and Alborz as a distinct group had the lowest values of catalase, hydrogen peroxide and malon dialdehyde, in addition to high values of antioxidant enzymes. However, accumulation of Na and Cl under salt stress was high in the varieties but damage severity decreased because of increase in antioxidant enzymes activity that led to stop oxidative stress. Also, it is very probable that they have a special ability in leaves to detoxification Na and Cl. These genotypes were known as tolerant varieties which those may be applied in wheat breeding programs for salt tolerance. Totally, each of the varieties had some appropriate tolerance mechanisms to defense with salinity and the results clarified genetic variation in this regard.
Bone methabolic disorders in HIV positive patients: a case report

Fractures in patients affected by HIV are more frequent than what is reported in patients with no retroviral diseases. Chronic infection with HIV likely contributes to increased systemic inflammation, which has been associated with increased rates of fracture. We report a case of a 56-year-old male (HIV + in treatment with Atripla) heavy worker, at the beginning affected by intra-articular proximal humerus fracture treated with endoprosthesis replacement and later by periprosthetic fracture treated with plate, screws and cerclages. Follow up was performed with clinical evaluation (ROM, VAS, Quick Dash, ASES, Simple shoulder test, UCLA Score, Constant score) and shoulder radiographs. Bone metabolism disorders in HIV patients lead to low BMD values, changes in bone turnover markers, and histomorphometric abnormalities, especially when HIV is present along with HCV or other hepatopathies. Additional therapy with bisphosphonate and Vitamin D should always be carried out when possible to prevent such types of orthopaedic complications. (www.actabiomedica.it)
Loss of NO(g) to painted surfaces and its re‐emission with indoor illumination

Abstract Heterogeneous surface reactions play a key role in the chemistry of the indoor environment because of the large indoor surface‐to‐volume ratio. The presence of photocatalytic material in indoor paints may allow photochemical reactions to occur at wavelengths of light that are present indoors. One such potential reaction is the heterogeneous photooxidation of NO to HONO. NO(g) is commonly found indoors, originating from combustion sources, ventilation and infiltration of outdoor air. We studied the interaction of NO(g) with painted surfaces illuminated with indoor fluorescent and incandescent lighting. There is a loss of NO(g) to painted surfaces in the dark at both 0 and 50% RH. At 50% RH, there is a re‐release of some of that NO(g) under illumination. The same behavior is observed for illumination of different colored paints. This is in contrast to what is seen with TiO2 as the substrate, where photoenhanced uptake of NO(g) and formation of NO2(g) are observed. We hypothesize that the loss of NO(g) is due to adsorption and diffusion into the paint. The re‐release of NO under illumination is thought to be due to photooxidation of NO to HONO on the painted surface at higher relative humidities and subsequent HONO photolysis.
Oligometastatic breast cancer: where are we now and where are we headed?-a narrative review.

Metastatic breast cancer has traditionally been considered incurable, with treatments focused on systemic therapies and palliative local treatment. However, evidence is emerging that in some patients with limited metastatic disease, or "oligometastatic disease," often defined as five or fewer metastases diagnosed on imaging, aggressive metastasis-directed therapy (MDT) with surgery and/or hypofractionated imageguided radiation therapy (HIGRT) improves outcomes and may even be curative. This practice is becoming more common as evidence has grown to support the approach and as technology has made it more feasible. Treatment of certain oligometastatic breast cancers in particular (i.e., hormone receptor positive and boneonly metastases) may be especially useful given the long natural history of the disease in some of these patients. Recently, high quality data supporting ablative MDT in patients with oligometastatic disease has emerged from randomized trials for specific sites such as non-small cell lung cancer and prostate cancer, as well as from histology agnostic studies (i.e., SABR-COMET). However, randomized data in breast cancer specifically is currently lacking. Retrospective series and subgroup analysis from prospective trials have demonstrated improved outcomes with MDT for oligometastatic breast cancer. The ongoing phase II/III NRG BR002 trial seeks to provide the first randomized data to determine whether MDT in oligometastatic breast cancer improves outcomes. This may be especially important as improved systemic therapies such as targeted agents and immunotherapy prolong the disease course. Alternatively, if improved systemic therapies render patients disease free, MDT may not be necessary and only adds toxicity. However, MDT may also provide non-curative benefits for patients such as palliation of symptoms and extended time off systemic therapy. For now, aggressive MDT for certain favorable subgroups of oligometastatic breast cancer such as those with few metastases, hormone positive disease, and/or bone-only metastases is reasonable and may improve outcomes. We eagerly anticipate the results of NRG BR002 to further clarify the role of ablative therapy to all sites of disease in these patients.
Insights from healthcare academics on facilitating interprofessional education activities

ABSTRACT Facilitators are of paramount importance to the success of interprofessional education (IPE) activities; hence, it is crucial to explore their perspectives and experiences in delivering IPE in Qatar. Using an exploratory case study approach, semi-structured interviews were conducted, in 2018, among faculty members, who had facilitated at least one IPE activity in Qatar, from healthcare professional education programs at Qatar University Colleges of Pharmacy, Medicine, and Health Sciences, Weill Cornell Medicine in Qatar, the University of Calgary in Qatar, and the College of North Atlantic. Interviews were recorded and transcribed verbatim. Inductive thematic content analysis was implemented. Twenty-one interviews were conducted with the following professions represented: medicine (n = 6), pharmacy (n = 5), nursing (n = 4), biomedical science (n = 3), respiratory theory (n = 2) and public health (n = 1). Four main themes emerged from the interviews: drivers to facilitator involvement that included interest and commitment to IPE and awareness of collaborative practice benefits; facilitator participation which was based on facilitator attributes and preparedness and readiness for IPE facilitation; the organizational support in terms of dedicated structure for IPE and IPE design and delivery and; student participation in terms of group dynamics and student engagement. Some key recommendations include having a dedicated unit for IPE, scheduling protected time for IPE, and organizing facilitators’ training and debriefing workshops. The facilitators valued and appreciated IPE in preparing students for future collaborative practice. These findings can inform the development of quality and sustainable IPE activities in the future.
Public health nurses' experiences learning and delivering a group cognitive behavioral therapy intervention for postpartum depression.

OBJECTIVES Public Health Nurses (PHNs) often provide support to women with postpartum depression (PPD) in the absence of specialized training. The objective of this study was to explore the experiences of six PHNs who were trained to deliver a group cognitive behavioral therapy (CBT) intervention for PPD in the public health setting, and to describe how learning and delivering this intervention affected their professional roles and personal lives. DESIGN This qualitative study employed a phenomenological approach. SAMPLE Six PHNs who completed the CBT training program and delivered at least one CBT group in their community. MEASUREMENTS Individual in-depth interviews were conducted and transcribed verbatim. Transcripts were analyzed according to thematic derivation procedures. RESULTS The themes that emerged from the interviews with the PHNs included: (a) components of the CBT training program that nurses most valued, (b) benefits of training for their professional role as a PHN, (c) implications for practice, and (d) using CBT skills in their personal lives. CONCLUSIONS The provision of CBT training to PHNs may not only positively impact their work with clients with mental illness, but may also have the potential to provide broader clinical and professional benefits for these skilled professionals and their other clients.
The role of histones and histone modifying enzymes in ribosomal dna silencing in saccharomyces cerevisiae

The Role of Histones and Histone Modifying Enzymes in Ribosomal DNA Silencing in Saccharomyces cerevisiae. (December 2008) Chonghua Li, B.S., Tsinghua University; M.S., Tsinghua University Chair of Advisory Committee: Dr. Mary Bryk In S. cerevisiae, the ribosomal DNA locus is silent for RNA polymerase II (Pol II) transcription and recombination (rDNA silencing). Our goal is to understand how histones and histone-modifying enzymes regulate the silent chromatin at the rDNA locus. Sir2, a NAD-dependent histone deacetylase, is required for rDNA silencing. To understand how Sir2 regulates rDNA silencing, we performed chromatin immunoprecipitation to measure the association of modified histones across the rDNA repeat in wild-type and sir2Δ cells. We found that in sir2Δ cells, histone H3 at the rDNA became hyperacetylated and hypermethylated. High levels of K4-methylated H3 correlate with Pol II transcription. Consistent with this, we found that the nontranscribed spacer (NTS) region was transcribed by Pol II in sir2Δ cells. To investigate if transcription of the NTS region regulates rDNA silencing, we overexpressed this region both in trans and in cis. Our data showed that overexpression of the NTS region in cis caused Pol II silencing defect and hyperrecombination at the rDNA. These data suggest that Sir2 contributes to maintain the silent chromatin at the rDNA by repressing Pol II
Impact of MRI Selection on Triage of Endovascular Therapy in Acute Ischemic Stroke: The MRI in Acute Management of Ischemic Stroke (MIAMIS) Registry

Background: The recently published multicenter randomized DAWN trial confirmed greater outcome benefit of endovascular therapy (ET) for anterior circulation large vessel occlusion ischemic stroke from 6 to 24 h from symptom onset compared to medical management in patients selected by advanced imaging with MRI or perfusion CT to identify mismatch between clinical deficit and infarct volume, which represents salvageable penumbra. The debate of CT over MRI is usually the potentially increase time consumption and the difficulty in establishing an adequate standardized workflow utilizing MRI during the hyperacute phase. Purpose: While CT-based selection of patients is the current standard of care, we sought to determine the time impact of the alternative approach of MRI selection in the 0–12 h window. Methods: In the MRI in Acute Management of Ischemic Stroke (MIAMIS) registry, we retrospectively analyzed 89 consecutive patients from January 2008 to January 2010 who presented with acute stroke symptoms with a National Institutes of Health Stroke Scale score ≥5 or aphasia within 0–12 h from symptom onset. The presence of penumbra was determined by MR perfusion-diffusion mismatch or clinical diffusion mismatch. Patients were stratified based on the presence of mismatch and clinical outcomes in patients who received ET. Imaging times were recorded. Results: The MRI turnaround time was 95.5 ± 48.5 min. The total MRI time was 27.7 ± 12.8 min. Seventeen (19.1%) patients were found to have nonvascular etiology. Mismatch was found in 35 (48.6%) patients with acute ischemic stroke (AIS). Patients with nonvascular etiology were younger (55.7 vs. 65.6 years, p < 0.02), without any vessel occlusion or mismatch noticed in this group. We dichotomized the 39 AIS patients with vessel occlusion into two subgroups: these with mismatch and these without. Patients without mismatch were older (76.7 vs. 64.4 years, p < 0.05), more likely to have congestive heart failure (71.4 vs. 22%, p < 0.03), a higher total serum cholesterol level (196 vs. 156 mg/dL, p < 0.04), and medium to large lesions on diffusion-weighted imaging (DWI) (85.7 vs. 37.5%, p < 0.04). Conclusions: Multimodality MRI screening for AIS symptoms for ET is feasible. Optimizing each center’s protocol and the utilization of MRI with DWI only may be a time-saving alternative.
New Machine Learning Approach for Detection of Injury Risk Factors in Young Team Sport Athletes

Abstract The purpose of this article is to present how predictive machine learning methods can be utilized for detecting sport injury risk factors in a data-driven manner. The approach can be used for finding new hypotheses for risk factors and confirming the predictive power of previously recognized ones. We used three-dimensional motion analysis and physical data from 314 young basketball and floorball players (48.4% males, 15.72±1.79 yr, 173.34±9.14 cm, 64.65±10.4 kg). Both linear (L1-regularized logistic regression) and non-linear methods (random forest) were used to predict moderate and severe knee and ankle injuries (N=57) during three-year follow-up. Results were confirmed with permutation tests and predictive risk factors detected with Wilcoxon signed-rank-test (p<0.01). Random forest suggested twelve consistent injury predictors and logistic regression twenty. Ten of these were suggested in both models; sex, body mass index, hamstring flexibility, knee joint laxity, medial knee displacement, height, ankle plantar flexion at initial contact, leg press one-repetition max, and knee valgus at initial contact. Cross-validated areas under receiver operating characteristic curve were 0.65 (logistic regression) and 0.63 (random forest). The results highlight the difficulty of predicting future injuries, but also show that even with models having relatively low predictive power, certain predictive injury risk factors can be consistently detected.
Impact of Bio- Socio demographic characteristics on the Quality of life of Breast Cancer Patients

Impact of BioSocio demographic characteristics on the Quality of life of Breast Cancer Patients Alyaa Farouk , Agnes Monica, Reem Almutairi, Nouf Alanazi, Manar Alenizi, Badriah Alotaibi 1 Community Health Nursing, College of Nursing-Riyadh, King Saud Bin Abdul-Aziz University for Health Sciences, KSA 2 Community Health Nursing Department, Faculty of Nursing, Alexandria University, Egypt 3 Psychiatric Health Nursing, College of Nursing-Riyadh, King Saud Bin Abdul-Aziz University for Health Sciences, KSA 4 Student, College of Nursing-Riyadh, King Saud Bin Abdul-Aziz University for Health Sciences, KSA
Emerging roles of the MAGE protein family in stress response pathways

The melanoma antigen (MAGE) proteins all contain a MAGE homology domain. MAGE genes are conserved in all eukaryotes and have expanded from a single gene in lower eukaryotes to ∼40 genes in humans and mice. Whereas some MAGEs are ubiquitously expressed in tissues, others are expressed in only germ cells with aberrant reactivation in multiple cancers. Much of the initial research on MAGEs focused on exploiting their antigenicity and restricted expression pattern to target them with cancer immunotherapy. Beyond their potential clinical application and role in tumorigenesis, recent studies have shown that MAGE proteins regulate diverse cellular and developmental pathways, implicating them in many diseases besides cancer, including lung, renal, and neurodevelopmental disorders. At the molecular level, many MAGEs bind to E3 RING ubiquitin ligases and, thus, regulate their substrate specificity, ligase activity, and subcellular localization. On a broader scale, the MAGE genes likely expanded in eutherian mammals to protect the germline from environmental stress and aid in stress adaptation, and this stress tolerance may explain why many cancers aberrantly express MAGEs. Here, we present an updated, comprehensive review on the MAGE family that highlights general characteristics, emphasizes recent comparative studies in mice, and describes the diverse functions exerted by individual MAGEs.