Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics of Patients With Bipolar Disorder Managed in VA Primary Care or Specialty Mental Health Care Settings

Objectives: This study compared the clinical characteristics, use of guideline-concordant pharmacotherapy, and outcomes of patients diagnosed as having bipolar disorder who were exclusively seen in Department of Veteran Affairs (VA) primary care settings with those of patients with bipolar disorder who received any VA mental health services. Methods: Data from the 1999 Large Health Survey of Veterans were linked to VA data from the National Psychosis Registry to identify patients diagnosed as having bipolar disorder (N=14,643). Multivariable analyses adjusting for sociodemographic characteristics and clinical and severity factors determined whether exclusive primary care use versus any mental health care use was associated with poor clinical and services outcomes. Results: Overall, 7.6% used primary care services exclusively. Compared with persons who used specialty care services, those who used primary care exclusively were more likely to be diagnosed as having cardiovascular disease (odds ratio [OR]=1.26, p<.05) or hypertension (OR=1.31, p<.01), less likely to receive guideline-concordant pharmacotherapy (OR=.18, p<.001), more likely to have an inpatient medical visit (OR=1.36, p<.01), and less likely to have an inpatient psychiatric visit (OR=.36, p<.001). Persons who received only primary care were more likely to have worse physical health and better mental health, as measured by the 36-Item Short-Form Health Survey. Conclusions: Patients with bipolar disorder treated in primary care settings were more likely than those who received some care in a mental health specialty setting to have comorbid general medical disorders. Optimal care settings for patients with bipolar disorder may require strategies that address gaps in general medical as well as psychiatric care. (Psychiatric Services 61:500– 507, 2010)
A descriptive model of the cigarette epidemic in developed countries

It has been estimated that cigarettes are the cause of the deaths of one in two of their persistent users, and that approxi mately half a billion people currently alive-8% of the world's population could eventually be killed by tobacco if current smoking patterns persist. De spite this pandemic, tobacco consump tion continues and is increasing in many countries, especially in Asia and in Southern and Eastern Europe. A major factor affecting public awareness of the substantial health hazards of tobacco use is the three- to four-decade lag between the peak in smoking prevalence and the subsequent peak in smoking-related mortality. Based on nearly 100 years of observations in countries with the longest history of widespread cigarette use, a four-stage model of cigarette consump tion and subsequent mortality among men and women is proposed. From the model it is clear that, during certain periods of evolution of this epidemic, it is to be expected that smoking-attributable mortality will rise at the same time that smoking prevalence might be decreasing. This is because current mortality is most closely related to previous, not current, levels of cigarette consumption. Broad geographic classifications of regions are given, according to the stage of the epidemic that they are currently ex periencing. Tobacco control policy im plications for countries at each of the four stages of the cigarette epidemic are also discussed.
Aminonaphthoquinones as potential anti-breast cancer agents

A small library of compounds, including aminonaphthoquinones, heterocyclic and aromatic compounds, was synthesized to determine their antiproliferative activity against three mammalian cancer cell lines viz:cervical carcinoma (HeLa), breast adenocarcinoma (MCF-7) and T-cell leukaemia (Jurkat). Investigations into the effect of the compounds on coagulation and platelet activity were also undertaken. In particular, the aminonaphthoquinones showed significant antiproliferative activity against the three cell lines, with aminonaphthoquinone4 showing more potent antiproliferative activity when compared to camptothecin (PC). This quinone was also identified as possessing significant antiplatelet activity in vitro, by inhibiting both platelet aggregation and platelet adhesion. Key words: Aminonaphthoquinones, anticancer activity, anticoagulant, antiplatelet.
VOLUNTARY TEETH CLENCHING DURING PHYSICAL EXERCISE IN NATURAL ENVIRONMENT: PREVALENCE AND GENDER DIFFERENCES

Background/Objectives: Voluntary teeth clenching (VTC) has been researched with respect to performance enhancement, but little evidence has verified its prevalence. This study’s objective was to determine if VTC occurred during exercise in a natural environment. Secondarily, if differences in VTC existed based on gender and exercise type were investigated. Methods: Ambulatory surface electromyography (EMG) recorders were used to measure activities in the masseter and temporalis muscles and detect VTC during leg extension and general weight-lifting exercises in 7 male and 10 female subjects recruited from UMKC soccer teams. All subjects gave informed consent to participate in IRBapproved study protocols. Laboratory surface EMG recording during static and dynamic biting tasks established linear regression relations between EMG:bite-force for each subject. Then subject-specific thresholds for VTC ranging from 5-80% of a 20 N bite-force (T20N) were applied to detect and measure VTC in ambulatory data. Duty factors (DF=time clenching/total recording time, %) were compared for each VTC threshold and gender/exercise/muscle combination by simple test effect. Statistical significance was set at p<. 05 with a Bonferroni correction. Results: VTC was shown by all subjects at a threshold of ≤5%T20N, by 47% of subjects at a threshold of 50%T20N, and by 29% of subjects at a iv threshold of 80%T20N. Females tended to have a higher DF at all thresholds during weightlifting (highest DF at 5%T20N: 5.8%), while males tended to have higher DF during leg extensions (highest DF at 5%T20N: 7.1%). Gender differences in DF were significant during weight-lifting at all thresholds except at 80%T20N and during leg extensions at levels ≤25%T20N; and showed larger effect sizes for standardized leg extension compared to general weight-lifting exercises. Conclusions: Low level clenching was common during weight bearing exercises. Prevalence depended on threshold magnitudes defining clenching. There were gender, exercise-type and muscle differences in VTC.
Comparing prasugrel to twice daily clopidogrel post percutaneous coronary intervention in a Veterans Affairs population.

OBJECTIVE The purpose of this study was to compare various antiplatelet regimens in patients who experienced increased platelet reactivity on clopidogrel therapy with regards to cardiovascular outcomes, including need for revascularization, myocardial infarction (MI), stroke, and cardiovascular (CV) death. METHODS A retrospective chart review was conducted on patients who received percutaneous coronary intervention (PCI) at the Richard L. Roudebush Veterans Affairs Medical Center and were subsequently prescribed either clopidogrel 75 mg twice daily, prasugrel 10 mg daily, or clopidogrel 75 mg daily with high platelet reactivity between October 1, 2009 and November 30, 2010. Correlations between antiplatelet regimens and prevention of cardiovascular outcomes and bleeding events were evaluated. Groups were evaluated statistically as two separate comparisons; the first comparison being clopidogrel twice daily versus prasugrel and the second comparison being clopidogrel twice daily versus clopidogrel daily in those patients with a P2Y12 test result of less than 50%. RESULTS A total of 108 patients were included in the study. Eight events occurred in the clopidogrel twice daily group (n = 26), including five revascularizations and three MIs. Seven events occurred in the prasugrel group (n = 64), including two revascularizations, two MIs, two strokes, and one CV death. The difference between these groups was statistically significant (p = 0.031), with patients in the prasugrel group experiencing fewer events. Five events occurred in the clopidogrel daily group (n = 18), including one need for revascularization, two MIs, and two instances of CV death. There were no statistically significant differences in CV events between the clopidogrel twice daily group and clopidogrel daily group (p > 0.999). There were also no statistically significant differences in bleeding incidents for either of the comparisons; p > 0.999 and p = 0.676 respectively for the first and second comparisons. CONCLUSION Patients on prasugrel had fewer cardiovascular events as compared to patients on clopidogrel twice daily with no difference in bleeding events. No difference was seen with regards to cardiovascular or bleeding events when comparing clopidogrel twice daily to clopidogrel daily in patients with increased platelet reactivity. Study results suggest that there is no benefit to dosing clopidogrel twice daily when compared to either prasugrel or once daily clopidogrel dosing.
Outcomes of an extended-infusion piperacillin-tazobactam protocol implementation in a community teaching hospital adult intensive care unit.

OBJECTIVE The purpose of this study is to evaluate the outcome differences between patients receiving piperacillin-tazobactam pre- and post-implementation of an extended infusion dosing protocol in a community teaching hospital adult intensive care unit. METHODS On December 19th, 2011, extended infusion dosing of piperacillin-tazobactam was implemented at St. John's Hospital's intensive and cardiac care units (ICU/CCU) following IRB-approval. This is a historical case-control cohort study involving review of electronic medical charts of patients who received traditional or extended infusion therapy. Data was collected for patients that received piperacillin-tazobactam in the ICU/CCU from December 19th, 2010 through March 19th, 2011 for traditional infusion and from December 19th, 2011 through March 19th, 2012 for extended infusion. Primary endpoints were ICU/CCU mortality at discharge and length of stay. RESULTS The study included 113 patients with 52 in the traditional-infusion group and 61 extended-infusion group. There was no statistically significant difference in the primary end-point of ICU/CCU mortality between the two groups (14.8% vs. 21.1%; p = 0.374). In the extended infusion group, there was a shorter length of ICU and CCU stay (8.32 vs. 12.06 days; p = 0.025) and shorter length of hospital stay (11.32 vs. 19.7 days; p = 0.006). The extended-infusion group showed a decrease in cost of therapy that was statistically significant ($120.21 vs. $155.17; p = 0.035). Adverse drug effects did not differ between the two study groups. CONCLUSION This study showed that treatment with extended-infusion piperacillin-tazobactam therapy improved patient outcomes while maintaining patient safety and decreasing costs.
Relationship between Uncertainty and Emotions in Advanced Lung Cancer Patients after Initial Therapy.

PURPOSE We investigated the relationship between uncertainty and emotions in advanced lung cancer patients after initial therapy. METHODS Fourteen advanced lung cancer patients participated in this study. A survey was conducted using the Universal Uncertainty in Illness Scale (UUIS) and the Profile of Mood States-Brief Form (POMS-Brief Form), Japanese Version. RESULTS The total UUIS score of each participant ranged from 42 to 109, with a mean±SD of 70.7±20.9. The T-scores for the 6 factors of the POMS-Brief Form were 50.2±11.9 (mean±SD) for tension-anxiety (T-A); 49.6±12.2 for depression-dejection (D); 40.4±4.9 for anger-hostility (A-H); 41.8±9.3 for vigor (V); 44.2±5.8 for fatigue (F); and 52.7±15.2 for confusion (C). In terms of the correlation between the total UUIS score and the respective T-scores of the six POMS-Brief Form factors, a strong correlation was seen between total UUIS score and D (r=0.735, p=0.003). A substantial correlation was also seen between total UUIS score and T-A (r=0.694, p=0.006). CONCLUSIONS In advanced lung cancer patients after initial therapy, uncertainty had an effect on emotions. J. Med. Invest. 64: 96-100, February, 2017.
Obesity and Poverty: Are Food Stamps to Blame?

Sixty-six percent of adults in the United States are overweight, and 32% of Americans are obese. Although poverty is usually associated with being underfed and underweight, in the United States, the paradoxical relationship between poverty and overweight exists. This article examines the relationship between Food Stamp Program (FSP) participation, food choices, and overweight status. This article examines the practicality of an individual in New York adhering to U.S. Department of Agriculture (USDA) recommendations for a diet rich in whole grains, lean meats, fruits, and vegetables on a FSP budget. The authors concluded that a diet that consists of more processed, high-calorie foods is significantly more agreeable with a FSP budget than a diet that meets USDA recommendations.
Immunopathologic Findings in Systemic Sclerosis Patients

ABSTRACT Direct immunofluorescence (DIF) of the skin biopsy specimens was performed in 62 patients with systemic scleroderma: 26 cases of acrosclerosis (group 1), 26 cases of diffuse scleroderma (group 2) and ten cases of transitional form acrosclerosis‐diffuse scleroderma (group 3). If epidermal nuclear fluorescence and lupus band test (LBT) were considered, the results were positive in 15.3% in group 1, 42.3% in group 2, and 10% in group 3. LBT was positive in 13.5% of the cases in groups 1 and 2 and negative in group 3. The immunoglobulin deposits at the dermoepidermal consisted mainly of IgM or a combination of IgG and IgM. There was no correlation between the LBT and antinuclear antibodies as detected by indirect immunofluorescence (IIF) or double immunodiffusion (DID).
Identidade Social e Auto-Estima em Participantes de Grupos de Dança Flamenca: a Contribuição Pedagógica e Psicológica ao ser do Homem em Movimento

Este estudo descreveu a aproximacao e o estabelecimento de um ponto de intersecao (interdisciplinaridade e transdisciplinaridade) do movimento humano a partir dos conceitos da Psicologia, Psicanalise, Interacionismo Simbolico e da Ciencia da Motricidade Humana. O desenvolvimento deste trabalho focalizou a danca flamenca como ferramenta psicopedagogica na manutencao da identidade social e auto-estima. O objetivo desta pesquisa foi verificar a relacao entre o grau de identificacao social mantido por individuos pertencentes a grupos naturalmente formados (dancarinos de flamenco), a valoracao a que os mesmos atribuiam a seus proprios grupos (�in-group�) e a outros grupos (�out-groups�) e, finalmente, averiguar se a figura do mestre exerce a funcao de agente externo facilitador da identidade social dos alunos. Para tal, utilizou-se os seguintes instrumentos: questionario de avaliacao de tipicidade e valencia (flamenco e ballet classico, flamenco e nao dancarinos), questionario de avaliacao de positividade e escala de auto-estima coletiva, perguntas adicionais para avaliacao do grau de identificacao com o grupo, perguntas apresentadas aos professores de flamenco e suas respostas. A amostra consistiu de 200 bailarinos de flamenco distribuidos em dois grupos de 100. Os resultados demonstraram que quanto maior o nivel de identificacao dos bailarinos de flamenco com o seu grupo, mais favoraveis foram as suas avaliacoes a respeito destes. A representacao do professor como incentivador dos processos identificatorios grupais e definitiva. O comportamento de dancar opera intimamente com a palavra, e o verbo e investido de significado e qualidade que serao enviados aos receptores sensoriais e mentais. Assim, o reconhecimento da propria imagem e primordial as mocoes intersubjetivas. Concluiu-se que a identidade dos bailarinos e tao fortemente constituida que a eles e indiferente o que se passa externamente ao seu grupo. E o flamenco espelhando corporalmente as memorias recriadas ao longo da historia do ser do Homem sustenta o sentimento de auto-estima, entao gerado a partir da identidade social construida.
Vers une thérapie cellulaire des pathologies rétiniennes

272 > La proportion de sujets atteints de dégénérescence maculaire liée à l’âge dépasse 6 % des personnes âgées de plus de 65 ans [1]. Cette pathologie rétinienne conduit à la perte de la vision centrale, affecte en partie les cellules de l’épithélium pigmentaire de la rétine et la membrane de Bruch au niveau de la macula, la partie centrale de la rétine (Figure 1). Les cellules de l’épithélium pigmentaire de la rétine sont indispensables à la vision. En effet, elles sont au contact direct des cellules photoréceptrices, responsables de la phototransduction. Ce contact leur permet de recycler les photopigments des cellules photoréceptrices et de participer au renouvellement des segments externes de ces cellules par phagocytose (Figure 1).
Gekreuzter Sperm‐Penetration‐Meter Test Prognostische Wertigkeit bei der androgenen Subfertilität

Zusammenfassung: Bei 57 Ehepaaren mit einer therapieresistenten oder ungeklärten Ehesterilität wurde der SPM‐Test in doppelt gekreuzter Form durchgeführt. Die Ergebnis‐se des SPM‐Testes wurden einerseits mit den Ergebnissen des PCT und andererseits mit der Dauer des Kinderwunsches sowie den Befunden der männlichen und weiblichen Steri‐litätsdiagnose verglichen. Zwischen dem PCT und dem SPM‐Test konnte nur in 63% der Fälle eine Übereinstimmung der Ergebnisse festgestellt werden. Während eine Abhängig‐keit der Penetrationsfähigkeit der Spermatozoen im Cervikalschleim von der Anzahl der progressiv motilen Spermatozoen pro ml deutlich erkennbar war, konnte zwischen den Ergebnissen des SPM‐Testes und den gynäkologischen Befunden kein Zusammenhang festgestellt werden. Die Untersuchungen ergaben, daß die primäre Sterilitätsdiagnose in vie‐len Fällen erweitert werden konnte bzw. daß in vielen Fällen mit ungeklärter Sterilitätsur‐sache eine gestörte Spermatozoen‐Mukus‐Interaktion angenommen werden muß.
Lipid-bound sialic acid in psoriasis and its correlation with disease severity

Background: Psoriasis is a common chronic persistent inflammatory skin disorder distinguished by hyperproliferation and reduced differentiation of keratinocytes. The inflammatory processes involved may be associated with the development of co-morbidities. Increased levels of total sialic acid have been shown to correlate with inflammation and atherosclerotic processes. Serum sialic acid has been reported as a marker of the acute phase response; increased sialic acid concentrations have been observed in inflammatory diseases and cancer. Objectives of the Study: To estimate serum lipid-bound sialic acid (LBSA) levels in patients with psoriasis and a group of healthy controls. To evaluate the correlation between LBSA levels and the severity of the disease. Materials and Methods: Serum LBSA was estimated in patients and controls by Katopodis and stock method. The degree of severity of psoriasis was clinically assessed by Psoriasis Area and Severity Index (PASI) score for each patient. The statistical significance was evaluated using unpaired ′t′ test and Pearson′s correlation. Results: The mean levels of LBSA in psoriasis cases was found to be higher compared with controls, and it was statistically significant (P < 0.001). There was a mild negative correlation between LBSA levels and PASI , but it did not differ significantly. Conclusion: This study suggests the potential utility of serum LBSA as a biomarker of hyper proliferation, inflammation, and oxidative stress in psoriasis.
Two internet-based approaches to promoting HIV counselling and testing for MSM in China

The internet is an increasingly popular among gay men and other men who have sex with men (MSM) in China for finding sexual partners. Gay men and other MSM who meet online are at high risk for HIV infection but less likely to visit ‘traditional’ venues where they can receive interpersonal HIV prevention interventions. New virtual models are needed to provide HIV prevention messages and services to these gay men and other MSM. FHI 360 and Guangzhou Tongzhi (GZTZ) piloted separate but complementary approaches to using information and communications technology to promote uptake of HIV counselling and testing (HCT) among gay men and other MSM in three Chinese provinces (Yunnan Guangxi and Guangzhou). These approaches included dedicated websites featuring online risk assessment and appointment making crowd-sourced service promotion messages and dissemination via participants’ microblog accounts and social media profiles. Reach was measured using Web analytics and traditional monitoring and evaluation tools and government partners provided data on HCT uptake. The FHI 360 and GZTZ interventions reached 7000 and 2.3 million unique visitors respectively and contributed to increases in HCT uptake of 26% and 66% as well as to higher rates of HIV case finding. Internet-based interventions like those conducted by FHI 360 and GZTZ represent a promising channel for engaging otherwise difficult-to-reach gay men and other MSM in China.
Collagen deposition in liver disease

Collagen forms a small component of the total protein of normal liver, but in diseases which lead to cirrhosis and in cirrhosis itself it is deposited in large amounts throughout the organ. This leads to structural disruption of normal liver architecture (Fig. 1). The effects of this are the creation of portosystemic shunts within the liver (Hase, 1968) and perhaps the formation of a connective tissue diffusion barrier in the space of Disse between hepatocytes and their vascular supply. This paper presents evidence that collagen deposition in liver disease is due, at least in part, to increased collagen synthesis. Those liver cells which are responsible for collagen synthesis and the regulation of the synthesis of this protein in the diseased liver are also briefly discussed. Collagen synthesis Collagen synthesis may readily be studied in mouse liver after one dose of carbon tetrachloride. After one dose the hepatocytes in the centre of the liver lobule undergo necrosis, the necrotic cells are then removed, and by the fifth day the centre of the lobule has become repopulated with new hepatocytes derived from the periportal area. During the healing of this lesion an increased amount of collagen can usually be visualized in the centre of the lobule three to five days after poisoning. These fibres disappear very rapidly and the liver is morphologically normal on the sixth to seventh day of the experiment. In this model the rate of collagen synthesis is increased 24 hours after injury, reaches a maximum
ALTERED KINEMATICS, KINETICS AND EMG ACTIVITY IN SUBJECTS WITH FUNCTIONAL INSTABILITY (FI) OF THE ANKLE JOINT DURING A SINGLE LEG DROP JUMP

In sports such as basketball the incidence of FI (recurrent sprain and feelings of “giving way” of the ankle joint) following lateral ankle sprain has been shown to exceed 70% (Yeung et al., 1994). To date no study has investigated simultaneously lower limb 3D kinematics, kinetics and ankle joint muscle activation during a jump landing technique in subjects with FI of the ankle joint.