Miracle-dz/UniFAR-FTUs huggingface dataset:
Structured Reflection on the Clinical Supervision of Supervisees With and Without a Core Mental Health Professional Background

This paper reflects on particular aspects of the author's supervisory relationships. A reflective framework was used to aid the process. The issue explored the factors involved when supervising supervisees without a core mental health professional background are explored; in particular, the factors of accountability and responsibility. To aid reflection, relevant literature was explored. Foundational/generic competencies that are typically acquired during professional training can be gained in other ways. Supervisors should spend time with all supervisees, not just those without a core mental health professional background, to learn more about their background, assumptions, and prior experiences. Through the reflective process the author learnt how, as a supervisor, there needs to be a constant process of learning and adaptation.
Supraciliary contraction segments: A new method for the treatment of presbyopia

Background and Objective: To evaluate the safety and effectiveness of supraciliary contraction segment implants (SCSIs) for the treatment of presbyopia. Materials and Methods: This prospective, non-comparative study comprised 10 eyes from five phakic and emmetropic 50-year-old subjects. Preoperative and postoperative near and distance visual acuity, topography, axial length, pachymetry, and intraocular pressure were analyzed. A 5.32-mm long and 0.85-mm thick piece of polymethyl methacrylat (PMMA) and a 5.32-mm long or 0.55-mm thick dried hydrophilic SCSI were placed within the scleral tunnels that were created 2 mm away from the limbus. The 500–550 μm deep tunnels were parallel to the limbus and four segments were implanted per eye. The SCSIs were entirely placed at a depth of approximately 85% in the sclera. Results: The uncorrected distance visual acuity was similar before and after the surgery (0.00 logMAR). The monocular mean uncorrected near visual acuity (UNVA) was 0.5 ± 0.0 before surgery, 0.12 ± 0.10 logMAR at 1 month after surgery, 0.16 ± 0.18 logMAR at 3 months after surgery, and 0.29 ± 0.16 logMAR at the 18-month follow-up. Conclusion: Despite obtaining satisfactory results at 6 months after the surgery, a follow-up of the SCSI intervention at 18 months revealed a regression of the early post-op UNVA improvement caused by a progressive outward movement of SCSIs.
Facts and Fallacies of Common Bile Duct Obstruction by Pancreatic Pseudocysts

Although it is commonly accepted that pancreatic pseudocysts can cause obstruction of the common bile duct, few documented examples of this phenomenon exist. Most cases of obstructive jaundice associated with pseudocysts appear to be due to fibrotic stricture of the intrapancreatic portion of the common bile duct, rather than to pressure on the duct by the pseudocyst. We report three additional cases, in two of which fibrosis and not the pseudocyst caused the biliary obstruction. This experience illustrates the imperative to perform intraoperative cholangiography after drainage of the pseudoeyst and the necessity of a biliary-enteric bypass if bile duct obstruction has not been relieved by simple decompression of the pseudoeyst.
MAMR Frequency Selection on [CoX/Pt]4 Media

In microwave-assisted magnetic recording (MAMR), the frequency selection of the assisted microwave magnetic field is important. In this paper, we set up a micromagnetic model of [CoX/Pt]<sub>4</sub> media with a different anisotropy configuration to study the frequency selection based on media signal-to-noise ratio (SNR) by the simulation of writing performance. By evaluating each layer’s SNR, we find that the four-layer integrated SNR-<inline-formula> <tex-math notation="LaTeX">$f$ </tex-math></inline-formula> relationship is more influenced by the top two layers, and the interlayer exchange coupling strength plays a dominant role on the consistent SNR-<inline-formula> <tex-math notation="LaTeX">$f$ </tex-math></inline-formula> curve in each media layer. When Hiec = 2000 Oe, the optimum frequency in each layer is coherent; when Hiec = 1000 Oe, the optimum frequency has a 2 GHz difference in four layers. When the average anisotropy field <inline-formula> <tex-math notation="LaTeX">$H_{k}$ </tex-math></inline-formula> is in a range of 19–25 kOe, the integrated optimum frequency <inline-formula> <tex-math notation="LaTeX">$f_{\mathrm {{op{-}all}}}$ </tex-math></inline-formula> with highest media SNR increases versus <inline-formula> <tex-math notation="LaTeX">$H_{\mathbf {k}}$ </tex-math></inline-formula> with a slope of 1.87 GHz/kOe, smaller than the ferromagnetic resonant frequency coefficient of around 3 GHz/kOe, which is beneficial for MAMR applications. With optimized intergrain exchange strength <inline-formula> <tex-math notation="LaTeX">$A_{\mathrm {gb}} = 0.25$ </tex-math></inline-formula> and optimum frequency <inline-formula> <tex-math notation="LaTeX">$f_{\mathrm {op}} = 23$ </tex-math></inline-formula> GHz, an areal writing density limit of 3 Tbit/in<sup>2</sup> can be achieved.
Simulación de tratamiento térmico por diferencias finitas

El objetivo del presente trabajo es modelar la etapa de enfriamiento durante un tratamiento termico en agua y aire de piezas cilindricas. Se implemento con el metodo de diferencias finitas en dos dimensiones, obteniendose un programa por computadora que ofrece de manera grafica la temperatura en diversos lugares de la pieza, en el tiempo.
Genetics of primary ovarian insufficiency

Primary ovarian insufficiency (POI) is characterized by a loss of ovarian function before the age of 40 and account for one major cause of female infertility. POI relevance is continuously growing because of the increasing number of women desiring conception beyond 30 years of age, when POI prevalence is >1%. POI is highly heterogeneous and can present with ovarian dysgenesis and primary amenorrhea, or with secondary amenorrhea, and it can be associated with other congenital or acquired abnormalities. In most cases POI remains classified as idiopathic. However, the age of menopause is an inheritable trait and POI has a strong genetic component. This is confirmed by the existence of several candidate genes, experimental and natural models. The variable expressivity of POI defect may indicate that, this disease may frequently be considered as a multifactorial or oligogenic defect. The most common genetic contributors to POI are the X chromosome‐linked defects. Here, we review the principal X‐linked and autosomal genes involved in syndromic and non‐syndromic forms of POI with the expectation that this list will soon be upgraded, thus allowing the possibility to predict the risk of an early age at menopause in families with POI.
Insights into immune structure, recognition, and signaling

In this volume of Immunological Reviews, the articles focus on the structural biology of immunoreceptors and what structure is telling us about function. The issue is unabashedly ‘receptor-centric’ and the proteins covered range from antigen receptors, innate receptors, and cytokine receptors, thereby providing an unusually comprehensive snapshot of the current state of the art in molecular immunology. Of all the major fields in biomedical research, including neurobiology, developmental biology, immunology, microbiology, and genetics, just to name a subset, perhaps structure in the broadest sense has had more of an impact on immunology and played more of a major role in guiding the evolution and maturation of the field than any other. Here, I use the term ‘structure’ to encompass not only direct structural approaches, such as x-ray crystallography and nuclear magnetic resonance spectroscopy (NMR), but also imaging, biophysical, molecular, and mechanistic approaches to interrogate aspects of molecular recognition, oligomerization, and signaling. Perhaps the fact that immunobiology is centered on questions of recognition and discrimination and is largely controlled by receptor-ligand systems has led to an unusually high level of sophistication about structure among immunologists. Personally speaking, having delved into structural questions in neurobiology and developmental biology, I can state without equivocation that the structural and molecular savvy of immunologists has led to greater mechanistic clarity underlying central tenets of the field compared to other disciplines. Dating back to the days of elucidating the first antibody structures and the relation between hypervariable regions and antigen recognition, to the transformative clarity of the first major histocompatibility complex (MHC) structures in explaining MHC restriction, to more recent biophysical and structural investigations of T-cell receptor (TCR) recognition of both classical and non-classical MHC, innate immune receptors such as natural killer (NK) and Toll-like receptors, and cytokine receptors, molecular science has illuminated the path for the experimentalists and assumed a large and highly visible role in immunobiology as a whole.
Community Awareness About Cardiopulmonary Resuscitation Among Secondary School Students in Riyadh

It is very important that every person in the community know about Cardiopulmonary Resuscitation (CPR) to save lives and improve the quality of community health. However, there is a lack of research studies related to community awareness about CPR. The aim of this study was to examine the awareness and knowledge among secondary school students. Across-sectional design study was conducted by assessing the responses to self administered developed questionnaire. The questionnaire includes 11 questions regarding the awareness and knowledge related to CPR. The four first questions also involved the attitude of students about the application of CPR. Five hundred and eighty males and females students from Riyadh secondary schools answered and completed the questionnaire. Results revealed that: Out of a study sample of 580 males and females secondary school students, 56% did not have proper CPR information. The proper CPR information was higher among females than males: it was 87% and 61% for females and males students respectively. A bout 67% of all students would like to know more about CPR. Discussion: We examine the community awareness about CPR among secondary schools in Riyadh. There are sparse published studies which investigated the knowledge of CPR among school students. However, the lack of proper CPR information among students in this study was higher than previous CPR awareness studies. The possible explanation for this could be that other studies were carried out with health professionals who usually trained or oriented about CPR. The positive attitude towards CPR was similar to previous findings indicating the important role of CPR in saving patients life. Larger sample size and inclusion for more schools and universities would offer more information. As a conclusion / recommendation: It was found that the overall attitude is positive towards CPR. However, the proper CPR information was insufficient. Since CPR plays vital role in saving people life more studies are needed to examine the CPR information among people who live in the community and suggest strategies to introduce CPR training.
Potential impact on survival of improved tumor downstaging and resection rate by preoperative twice-daily radiation and concurrent chemotherapy in stage IIIA non-small-cell lung cancer.

PURPOSE The main objectives of this study were (a) to ascertain the feasibility and toxicity of preoperative twice-daily radiation therapy and concurrent chemotherapy, surgery, and postoperative therapy in stage IIIA (N2) non-small-cell lung cancer (NSCLC), and (b) to evaluate tumor response, resection rate, pathologic tumor downstaging, and survival. METHODS Eligibility included biopsy-proven N2 lesion (stage IIIA) by mediastinoscopy, Karnofsky performance score > or = 70, and weight loss less than 5% in the 3 months before diagnosis. The treatment program consisted of two courses of preoperative cisplatin, vinblastine, and fluorouracil (5-FU); 42 Gy concurrent radiation at 1.5 Gy per fraction in two fractions per day; surgery on day 57; and one more course of postoperative chemotherapy and 12 to 18 Gy of concurrent twice-daily radiation. RESULTS Forty-two patients with stage IIIA (N2) NSCLC (27 men and 15 women, age 38 to 77 years) were enrolled onto this prospective study. Forty of 42 patients tolerated the intended dose (42 Gy) of preoperative radiation and 37 of 39 resected patients received prescribed postoperative radiation. The intended dose of chemotherapy was given in 100%, 70%, and 60% of patients for the first, second, and third courses of chemotherapy. Marked dysphagia that required intravenous hydration was noted in 14% of patients (six of 42). Myelotoxicities included grade > or = 3 granulocytopenia in 23% and thrombocytopenia in 6% of 113 chemotherapy courses. Febrile neutropenia that required hospital admission was noted in 9% of 113 chemotherapy courses. Surgical resection was performed in 93% of patients. Treatment-related mortality was noted in 7% of patients. The overall survival rates by the Kaplan-Meier method were 66%, 37%, and 37% at 2,3, and 5 years, respectively, with a median follow-up time of 48 months. Pathologic examination of the surgical specimen showed a downward shift in tumor extent from stage IIIA (N2) to stage II (N1) in 33%, to stage I (NO) in 24% (10 of 42), and to stage 0 (TONO) in 9.5%, for a total of 67%. The degree of tumor downstaging was also translated into a survival benefit: 5-year survival rates from the time of surgery were 79%, 42%, and 18% for postoperative tumor stages 0 and I, II, and III, respectively (P = .04). CONCLUSION Concurrent chemoradiotherapy using twice-daily radiation is an effective induction regimen that resulted in 67% tumor downstaging, and an encouraging 37% 5-year survival rate. The degree of tumor downstaging may be a useful intermediate end point for survival benefit in stage IIIA (N2) NSCLC.
Let's MPC the economy: stabilising the economy using more dynamic regulation

This work proposes a method for stabilising a nation’s macro economy. The idea is to use more dynamic regulation. At present, only the Central Bank’s short-run interest rate is used as a dynamic variable in the government monetary policy for stabilising the macro economy. The author suggests to make the value added tax (VAT) as a new dynamic regulation variable. The VAT can be adjusted monthly or quarterly coordinated with the Central Bank’s interest rate by a new independent agency called Central Tax Bureau (or by the Central Bank). The advantages of the method will be discussed; the implementation of the method will be outlined. Control theoretical analysis and computer simulation will be used to demonstrate the effectiveness of the method.
In Vitro Study of the Stress Response of Human Skin Cells to GSM-1800 Mobile Phone Signals Compared to UVB Radiation and Heat Shock

Abstract Sanchez, S. , Haro, E. , Ruffié, G. , Veyret, B. and Lagroye, I. In Vitro Study of the Stress Response of Human Skin Cells to GSM-1800 Mobile Phone Signals Compared to UVB Radiation and Heat Shock. Radiat. Res. 167, 572–580 (2007). The evolution of mobile phone technology is toward an increase of the carrier frequency up to 2.45 GHz. Absorption of radiofrequency (RF) radiation becomes more superficial as the frequency increases. This increasingly superficial absorption of RF radiation by the skin, which is the first organ exposed to RF radiation, may lead to stress responses in skin cells. We thus investigated the expression of three heat-shock proteins (HSP70, HSC70, HSP27) using immunohistochemistry and induction of apoptosis by flow cytometry on human primary keratinocytes and fibroblasts. A well-characterized exposure system, SXC 1800, built by the IT'IS foundation was used at 1800 MHz, with a 217 Hz modulation. We tested a 48-h exposure at an SAR of 2 W/kg (ICNIRP local exposure limit). Skin cells were also irradiated with a 600 mJ/cm2 single dose of UVB radiation and subjected to heat shock (45°C, 20 min) as positive controls for apoptosis and HSP expression, respectively. The results showed no effect of a 48-h GSM-1800 exposure at 2 W/kg on either keratinocytes or fibroblasts, in contrast to UVB-radiation or heat-shock treatments, which injured cells. We thus conclude that the GSM-1800 signal does not act as a stress factor on human primary skin cells in vitro.
Adipokines, Vascular Wall, and Cardiovascular Disease

Epidemiological evidence has shown that abdominal obesity is closely associated with the development of cardiovascular (CV) disease, suggesting that it might be considered as an independent CV risk factor. However, the pathophysiological mechanisms responsible for the association between these 2 clinical entities remain largely unknown. Adipocytes are considered able to produce and secrete chemical mediators known as “adipokines” that may exert several biological actions, including those on heart and vessels. Of interest, a different adipokine profile can be observed in the plasma of patients with obesity or metabolic syndrome compared with healthy controls. We consider the main adipokines, focusing on their effects on the vascular wall and analyzing their role in CV pathophysiology.
Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency.

BACKGROUND Vitamin D (vD) deficiency in pregnancy is a global health problem and the amount of vD supplementation to prevent vD deficiency is controversial. OBJECTIVE The objective of the study was to determine effectiveness and safety of prenatal 2000 IU and 4000 IU/d compared with 400 IU/d vD3 supplementation in a randomized controlled trial in population in which vD deficiency is endemic. DESIGN/METHODS Arab women were randomized at 12-16 weeks of gestation to 400, 2000, and 4000 IU/d vD3, which were continued to delivery. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured during pregnancy and at delivery. The primary outcome was the maternal and cord blood 25(OH)D, and the secondary outcomes were the achievement of sufficient serum 25(OH)D of 32 ng/mL or greater (≥80 nmol/L) at delivery. SETTING The locations were primary care and tertiary perinatal care centers. RESULTS Of 192 enrolled, 162 (84%) continued to delivery. Mean serum 25(OH)D of 8.2 ng/mL (20.5 nmol/L) at enrollment was low. Mean serum 25(OH)D concentrations at delivery and in cord blood were significantly higher in the 2000 and 4000 IU than the 400 IU/d group (P < .001) and was highest in the 4000 IU/d group. The percent who achieved 25(OH)D greater than 32 ng/mL and greater than 20 ng/mL concentrations in mothers and infants was highest in 4000 IU/d group. Safety measurements were similar by group and no adverse event related to vD supplementation. CONCLUSIONS Vitamin D supplementation of 2000 and 4000 IU/d appeared safe in pregnancy, and 4000 IU/d was most effective in optimizing serum 25(OH)D concentrations in mothers and their infants. These findings could apply to other populations in which vD deficiency is endemic.
Pre-touch proxemics: moving the design space of touch targets from still graphics towards proxemic behaviors

Proxemic touch targets continuously change in relation to a user's hand in mid-air before a physical touch occurs. Previous work has, for example shown that expanding targets are capable to improve target acquisition performance on touch interfaces. However, it is unclear how proxemic touch targets influence user experience (UX) in a broader sense, including hedonic qualities. Towards closing this research gap the paper reports on two user studies. The first study is a qualitative study with five experts, providing in-depth insights on a variety of change-types (e.g., size, form, color) and how they, for example, influence perceived functional and aesthetic qualities of proxemic touch targets. A follow-up user study with 36 participants explores the UX of a proxemic touch target compared to non-proximal versions of the same target. The results highlight a positive significant effect of the proxemic design on both pragmatic and hedonic qualities.
Economical Solution for an Easy to Use Interactive Whiteboard

This paper presents a new technology combining infrared tracking and Bluetooth communication to create an effective and low cost interactive whiteboard, the wiimote whiteboard. The author, a high school student, got the idea after he observed inattentive students and a deteriorating classroom environment on several occasions. After extensive research, he decided to solve the problem by building an interactive whiteboards. This paper gives the details, including how to gather the components, assemble the elements, install software, setup and calibrate the whiteboard. Due to the frequent low tracking resolution of the device, four methods of improving the tracking resolution are also provided, based on the author's many tests. Finally, the paper analyzes the basic theory, compares wiimote with the commercial whiteboard, introduces the history of the new technology, and lists a number of useful resources for referencing. With the help of the author's school and the advisor's funding, the device was successfully installed at Watertown High School of Connecticut.
Nurses' attitudes towards computers: cross sectional questionnaire study.

AIM To estimate the attitudes of hospital nurses towards computers and the influence of gender, age, education, and computer usage on these attitudes. METHODS The study was conducted in two Croatian hospitals where integrated hospital information system is being implemented. There were 1,081 nurses surveyed by an anonymous questionnaire consisting of 8 questions about demographic data, education, and computer usage, and 30 statements on attitudes towards computers. The statements were adapted to a Likert type scale. Differences in attitudes towards computers were compared using one-way ANOVA and Tukey-b post-hoc test. RESULTS The total score was 120+/-15 (mean+/-standard deviation) out of maximal 150. Nurses younger than 30 years had a higher total score than those older than 30 years (124+/-13 vs 119+/-16 for 30-39 age groups and 117+/-15 for>39 age groups, P<0.001). Nurses with a bachelor's degree (119+/-16 vs 122+/-14, P=0.002) and nurses who had attended computer science courses had a higher total score compared to the others (124+/-13 vs 118+/-16, P<0.001). Nurses using computers more than 5 hours per week had higher total score than those who used computers less than 5 hours (127+/-13 vs 124+/-12 for 1-5 h and and 119+/-14 for <1 hour per day, P<0.001, post-hoc test). CONCLUSION Nurses in general have positive attitudes towards computers. These results are important for the planning and implementing an integrated hospital information system.