Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of an extruded animal protein‐free diet on fecal microbiota of dogs with food‐responsive enteropathy

Background Dietary interventions are thought to modify gut microbial communities in healthy individuals. In dogs with chronic enteropathies, resolution of dysbiosis, along with remission of clinical signs, is expected with treatment. Hypothesis/Objective To evaluate changes in the fecal microbiota in dogs with food‐responsive chronic enteropathy (FRE) and in healthy control (HC) dogs before and after an elimination dietary trial with an animal protein‐free diet (APFD). Animals Dogs with FRE (n = 10) and HC (n = 14). Methods Dogs were fed the APFD for 60 days. Fecal microbiota was analyzed by Illumina 16S rRNA sequencing and quantitative polymerase chain reaction (PCR). Results A significantly lower bacterial alpha‐diversity was observed in dogs with FRE compared with HC dogs at baseline, and compared with FRE dogs after the trial. Distinct microbial communities were observed in dogs with FRE at baseline compared with HC dogs at baseline and compared with dogs with FRE after the trial. Microbial communities still were different in FRE dogs after the trial compared with HC dogs at baseline. In HC dogs, the fecal microbiota did not show a significant modification after administration of the APFD. Conclusion and Clinical Importance Our results suggest that, in FRE dogs, treatment with the APFD led to a partial recovery of the fecal microbiota by significantly increasing microbiota richness, which was significantly closer to a healthy microbiota after the treatment. In contrast, no changes were detected in the fecal microbiota of HC dogs fed the same APFD.
Abortion in Zimbabwe: A national study of the incidence of induced abortion, unintended pregnancy and post-abortion care in 2016

Background Zimbabwe has the highest contraceptive prevalence rate in sub-Saharan Africa, but also one of the highest maternal mortality ratios in the world. Little is known, however, about the incidence of abortion and post-abortion care (PAC) in Zimbabwe. Access to legal abortion is rare, and limited to circumstances of rape, incest, fetal impairment, or to save the woman’s life. Objectives This paper estimates a) the national provision of PAC, b) the first-ever national incidence of induced abortion in Zimbabwe, and c) the proportion of pregnancies that are unintended. Methods We use the Abortion Incidence Complications Method (AICM), which indirectly estimates the incidence of induced abortion by obtaining a national estimate of PAC cases, and then estimates what proportion of all induced abortions in the country would result in women receiving PAC. Three national surveys were conducted in 2016: a census of health facilities with PAC capacity (n = 227), a prospective survey of women seeking abortion-related care in a nationally-representative sample of those facilities (n = 127 facilities), and a purposive sample of experts knowledgeable about abortion in Zimbabwe (n = 118). The estimate of induced abortion, along with census and Demographic Health Survey data was used to estimate unintended pregnancy. Results There were an estimated 25,245 PAC patients treated in Zimbabwe in 2016, but there were critical gaps in their care, including stock-outs of essential PAC medicines at half of facilities. Approximately 66,847 induced abortions (uncertainty interval (UI): 54,000–86,171) occurred in Zimbabwe in 2016, which translates to a national rate of 17.8 (UI: 14.4–22.9) abortions per 1,000 women 15–49. Overall, 40% of pregnancies were unintended in 2016, and one-quarter of all unintended pregnancies ended in abortion. Conclusion Zimbabwe has one of the lowest abortion rates in sub-Saharan Africa, likely due to high rates of contraceptive use. There are gaps in the health care system affecting the provision of quality PAC, potentially due to the prolonged economic crisis. These findings can inform and improve policies and programs addressing unsafe abortion and PAC in Zimbabwe.
Poststroke Depression: Contributions From Network Science.

FIGURE 1. Poststroke depression (PSD) is common among survivors of stroke. A recent meta-analysis of population-based studies (green squares) and a longitudinal study that utilized a large stroke registry (blue squares) both reported that more than 30% of patients developed PSD within the first few months after a stroke. The longitudinal study also found that half of these cases remitted by 1 year. A similar pattern was reported in a study of first-ever ischemic stroke (pink squares). Of note, a study using data from a stroke registry that included patients with transient ischemic attacks (TIAs) reported similar rates of depression following stroke (gold squares)and TIA (gold triangles). Rates of developing major depression (MDD) after traumatic brain injury (TBI) are also similar when patients with moderate-severe TBI (orange squares) are compared with patients with mild TBI (orange triangles). Overall, these results suggest that severity of brain injury is not a primary pathophysiological mechanism for development of depression.
Emerging Roles for Adipose Tissue in Cardiovascular Disease.

Cardiovascular disease (CVD), diabetes mellitus and insulin resistance, and other obesity-related disorders remain a heavy disease burden in the United States and throughout the world. These disorders are interconnected, and adipose tissue is increasingly understood to be an important nexus of these related diseases. Adipose tissue itself comprises multiple cell types, including adipocytes, monocytes/macrophages, pericytes, endothelial cells, and various stem cells, and is thus a highly dynamic tissue with many functions. Additionally, adipose can alter the function of other tissues (liver, brain, heart, skeletal muscle, and vascular endothelium) from afar via the secretion of adipokines and bioactive molecules, thus making it a critical endocrine regulator of whole body metabolism. Given these functions, healthy adipose is important for metabolic homeostasis, whereas dysfunctional adipose is a contributing factor to metabolic disease pathogenesis. In this Recent Highlights article, we discuss recent publications from Arteriosclerosis, Thrombosis, and Vascular Biology and other journals that investigate this highly complex tissue and its various emerging roles in CVD pathophysiology.
Clinical effectiveness of golimumab in Crohn’s disease: an observational study based on the Swedish National Quality Registry for Inflammatory Bowel Disease (SWIBREG)

Abstract Objective: The effectiveness of golimumab in Crohn’s disease (CD) is largely unknown as it is not approved for the treatment of the disease. We aimed to identify the population of CD patients treated with golimumab in Sweden, to assess the effectiveness of golimumab (defined as the drug retention rate), and to identify predictors of drug discontinuation. Methods: Patients with CD who received at least one injection of golimumab were identified through the Swedish National Quality Registry for Inflammatory Bowel Disease, which includes prospectively collected clinical information. Cox regression models were used to identify predictors of golimumab discontinuation. Results: The study cohort involved 94 patients of whom the majority (96.8%) had previously discontinued at least one anti-tumour necrosis factor (anti-TNF) agent. The drug retention rate at 12 weeks was 85.1%. Predictors of golimumab discontinuation at 12 weeks were previous surgery (adjusted HR = 7.52, 95% CI: 1.12–50.36), concomitant corticosteroid use at baseline (adjusted HR = 5.70, 95% CI: 1.13–28.68) and female sex (adjusted HR = 6.59; 95% CI: 1.04–41.62). The median duration of follow-up was 89 (IQR: 32–158) weeks. The drug retention at the most recent follow-up was 35.1%. Predictors of golimumab discontinuation at the most recent follow-up were corticosteroid use at baseline (adjusted HR = 2.60, 95% CI: 1.17–5.79) and female sex (adjusted HR = 2.24; 95% CI: 1.19–4.23). Conclusion: Patients with CD treated with golimumab were a treatment-refractory group. Despite this, more than one-third of the patients appeared to have had clinical benefit after a median follow-up of more than 1.5 years.
Fatal intoxication with N-ethylpentylone: a case report

ABSTRACT Synthetic cathinones represent the latest genre of new drugs of abuse, which are increasing in popularity in part because they are readily available and because they are not detected by routine drug testing. They provide a cheaper substitute to stimulants such as methamphetamine and cocaine and are sold on the internet and in retail establishments as ‘bath salts,’ ‘plant food,’ or ‘research chemicals. ’ We report a case involving a 21-year-old male who suffered arrest-related death due to intoxication with N-ethylpentylone, a new cathinone derivative. He reportedly left his house to smoke marijuana and returned displaying extremely odd behavior. The patient was unresponsive upon presentation to the emergency room and was intubated after suffering cardiac arrest. Clinical laboratory values revealed elevated lactic acidosis, hyperkalemia, rhabdomyolysis, and renal injury. His condition continued to worsen despite medical management. Sudden cardiac arrest occurred again 72 hours into his hospital stay and the patient was pronounced dead. Post-mortem toxicology testing with gas chromatography and mass spectrometry determined the presence of N-ethylpentylone in the urine. This case report details the behavior effects, clinical presentation, and autopsy findings for N-ethylpentylone drug intoxication.
Konaklama İşletmelerinin Web Sayfa Tasarımlarının Pazarlama Uygulamaları Açısından İncelenmesi: Eskişehir Örneği

The purpose of this research is analyzing website of the hotels which have tourism management certificate in Eskisehir in terms of marketing practices. For this purpose, while hotels in Eskisehir represent the universe of this study, hotels which have tourism management certificate have been selected by purpose sampling method. Within this scope, websites were analyzed and content analysis was used. The majority of website have not had features such as online help form, exchange rate information, online questionnaire, proposal form, and visitor book. From these findings, it can be said that attention should be paid to the fact that the websites of the hotels should be more active and that marketing practices are used effectively.
A New LSA and Entropy-Based Approach for Automatic Text Document Summarization

Automatic text document summarization is active research area in text mining field. In this article, the authors are proposing two new approaches (three models) for sentence selection, and a new entropy-based summary evaluation criteria. The first approach is based on the algebraic model, Singular Value Decomposition (SVD), i.e. Latent Semantic Analysis (LSA) and model is termed as proposed_model-1, and Second Approach is based on entropy that is further divided into proposed_model-2 and proposed_model-3. In first proposed model, the authors are using right singular matrix, and second & third proposed models are based on Shannon entropy. The advantage of these models is that these are not a Length dominating model, giving better results, and low redundancy. Along with these three new models, an entropy-based summary evaluation criteria is proposed and tested. They are also showing that their entropy based proposed models statistically closer to DUC-2002's standard/gold summary. In this article, the authors are using a dataset taken from Document Understanding Conference-2002.
Incomplete Multiview Clustering via Late Fusion

In real-world applications of multiview clustering, some views may be incomplete due to noise, sensor failure, etc. Most existing studies in the field of incomplete multiview clustering have focused on early fusion strategies, for example, learning subspace from multiple views. However, these studies overlook the fact that clustering results with the visible instances in each view could be reliable under the random missing assumption; accordingly, it seems that learning a final clustering decision via late fusion of the clustering results from incomplete views would be more natural. To this end, we propose a late fusion method for incomplete multiview clustering. More specifically, the proposed method performs kernel k-means clustering on the visible instances in each view and then performs a late fusion of the clustering results from different views. In the late fusion step of the proposed method, we encode each view's clustering result as a zero-one matrix, of which each row serves as a compressed representation of the corresponding instance. We then design an alternate updating algorithm to learn a unified clustering decision that can best group the visible compressed representations in each view according to the k-means clustering objective. We compare the proposed method with several commonly used imputation methods and a representative early fusion method on six benchmark datasets. The superior clustering performance observed validates the effectiveness of the proposed method.
Evidence for a protective role of the CX3CL1/CX3CR1 axis in a model of amyotrophic lateral sclerosis

Abstract Aberrant microglial activation and neuroinflammation is a pathological hallmark of amyotrophic lateral sclerosis (ALS). Fractalkine (CX3CL1) is mostly expressed on neuronal cells. The fractalkine receptor (CX3CR1) is predominantly expressed on microglia. Many progressive neuroinflammatory disorders show disruption of the CX3CL1/CX3CR1 communication system. But the exact role of the CX3CL1/CX3CR1 in ALS pathology remains unknown. F1 nontransgenic/CX3CR1+/− females were bred with SOD1G93A/CX3CR1+/− males to produce F2 SOD1G93A/CX3CR1−/−, SOD1G93A/CX3CR1+/+. We analyzed end-stage (ES) SOD1G93A/CX3CR1−/− mice and progression-matched SOD1G93A/CX3CR1+/+ mice. Our study showed that the male SOD1G93A/CX3CR1−/− mice died sooner than male SOD1G93A/CX3CR1+/+ mice. In SOD1G93A/CX3CR1−/− mice demonstrated more neuronal cell loss, more microglial activation and exacerbated SOD1 aggregation at the end-stage of ALS. The NF-κB pathway was activated; the autophagy-lysosome degradation pathway and the autophagosome maturation were impaired. Our results indicated that the absence of CX3CR1/CX3CL1 signaling in the central nervous system (CNS) may worsen neurodegeneration. The CX3CL1/CX3CR1 communication system has anti-inflammatory and neuroprotective effects and plays an important role in maintaining autophagy activity. This effort may lead to new therapeutic strategies for neuroprotection and provide a therapeutic target for ALS patients.
Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients

Background and Purpose— Trimethylamine N-oxide (TMAO)—a gut derived metabolite—has been shown to be atherogenic. It remains unknown whether TMAO is associated with the risk of first stroke. We aimed to determine the association between serum TMAO levels and first stroke in hypertensive patients without major cardiovascular diseases and examine any possible effect modifiers. Methods— We used a nested case-control design, using data from the CSPPT (China Stroke Primary Prevention Trial), including 622 patients with first stroke and 622 matched controls. The study was conducted from May 2008 to August 2013. The primary outcome was a first stroke. Results— After adjusting for choline, L-carnitine, and other important covariates, including baseline systolic blood pressure and time-averaged systolic blood pressure, during the treatment period, the risk of first stroke increased with each increment of TMAO level (per natural log [TMAO] increment: odds ratio, 1.22; 95% CI, 1.02–1.46). Consistently, compared with participants in the lowest tertile (<1.79 &mgr;mol/L) of serum TMAO levels, a significantly higher risk of first stroke was found in those in higher TMAO tertiles (≥1.79 &mgr;mol/L; odds ratio, 1.34; 95% CI, 1.00–1.81) or in TMAO tertile 3 (≥3.19 &mgr;mol/L; odds ratio, 1.43; 95% CI, 1.02–2.01). In the exploratory analysis, we observed an interaction between TMAO and folate levels (≥7.7 [median] versus <7.7 ng/mL) on first stroke (P for interaction, 0.030). Conclusions— Higher TMAO levels were associated with increased risk of first stroke in hypertensive patients. Our finding, if further confirmed, calls for a carefully designed clinical trial to further evaluate the role of higher TMAO levels on outcomes in hypertensive patients. Clinical Trial Registration— URL: https://www.clinicaltrials. gov. Unique identifier: NCT00794885.
Global and Local Mesh Morphing for Complex Biological Objects from µCT Data

We show how biologically coherent mesh models of animals can be created from μCT data to generate artificial yet naturally looking intermediate objects. The whole pipeline of processing algorithms is presented, starting from generating topologically equivalent surface meshes, followed by solving the correspondence problem, and, finally, creating a surface morphing. In this pipeline, we address all the challenges that are due to dealing with complex biological, non-isometric objects. For biological objects it is often particularly important to obtain deformations that look as realistic as possible. In addition, spatially non-uniform shape morphings that only change one part of the surface and keep the rest as stable as possible are of interest for evolutionary studies, since functional modules often change independently from one another. We use Poisson interpolation for this purpose and show that it is well suited to generate both global and local shape deformations.
Training load and schedule are important determinants of sleep behaviours in youth-soccer players

Abstract The current study examined how sleep may be influenced by the scheduling of training and match load within 10 youth-soccer players. Sleep was measured over a 14-day in-season period using a commercially available wireless sleep monitor. Each collected sleep variable; lights out, sleep latency, total sleep time wake after sleep onset and final awakening, was compared for the specific day within the training schedule (e.g. match day [MD], day after match [MD + 1]) and to training/match load (high-speed distance (>5.5 m/s) [HSD] and rating of perceived exertion. The data were analysed using mixed models and effect sizes, to describe the magnitude of effects that training schedule and training load may have on sleep. A reduction of sleep duration was observed on the day after the match (MD + 1) in relation to the training days preceding the match (MD-2: −65 min, ES: 0.89 ± 0.79; MD-1 −61 min, ES: 0.82 ± 0.64) and reduction on match day (+45 min; ES: 1.91 ± 1.69). This may suggest youth-soccer players actively change their sleep scheduling behaviours in relation to the imposed soccer schedule. Increased high-speed running (for every 100 m) showed a small increase to total sleep time (+9 min; ES: 0.48 ± 0.31). This may suggest that increases in training load may be associated with small increases in sleep quantity. Such observations may highlight that the type of day and the associated load within the training microcycle may have important consequences for sleep within youth-soccer players.
Aphid populations showing differential levels of virulence on Capsicum accessions

The green peach aphid, Myzus persicae, is one of the most threatening pests in pepper cultivation and growers would benefit from resistant varieties. Previously, we identified two Capsicum accessions as susceptible and three as resistant to M. persicae using an aphid population originating from the Netherlands (NL). Later on we identified an aphid population originating from a different geographical region (Switserland, SW) that was virulent on all tested Capsicum accessions. The objective of the current work is to describe in detail different aspects of the interaction between two aphid populations and two selected Capsicum accessions (one that was susceptible [PB2013046] and one that was resistant [PB2013071] to population NL), including biochemical processes involved. Electrical penetration graph (EPG) recordings showed similar feeding activities for both aphid populations on PB2013046. On accession PB2013071 the aphid population SW was able to devote significantly more time to phloem ingestion than population NL. We also studied plant defense response and found that plants of accession PB2013046 could not induce an accumulation of reactive oxygen species and callose formation after infestation with either aphid population. However, plants of PB2013071 induced a stronger defense response after infestation by population NL than after infestation by population SW. Based on these results, population SW of M. persicae seems to have overcome the resistance of PB2013071 that prevented feeding of aphids from NL population. The potential mechanism by which SW population overcomes the resistance is discussed.
Reducing risk factors for cognitive decline through psychological interventions: a pilot randomized controlled trial

ABSTRACT Objectives: Modifiable factors associated with increased risk of cognitive decline include emotional (anxiety, depression), cognitive (low social and mental stimulation), and health factors (smoking, alcohol use, sedentary lifestyle, obesity). Older adults with anxiety and depression may be at heightened risk due to direct and indirect impacts of emotional distress on cognitive decline. Design: Randomized controlled trial Setting: Community sample attending a university clinic. Participants: 27 participants (female = 20) aged over 65 years (M = 72.56, SD = 6.74) with an anxiety and/or mood disorder. Interventions: two cognitive behavioral therapy (CBT) interventions (face-to-face or low intensity) that targeted emotional, health, and cognitive risks for cognitive decline. Measurements: Participants completed diagnostic interviews; self-report measures of anxiety, depression, quality of life, and lifestyle factors at baseline; post-treatment; and 3-month follow-up. Results: Both interventions resulted in significant and sustained improvements in depression, anxiety, quality of life, and physical and social activity. At post-treatment, face-to-face CBT demonstrated significantly greater improvements in emotional symptoms, alcohol use, and memory (exercise approached significance). At 3-month follow-up, gains were maintained and there were significantly greater increases in mental activity for face-to-face CBT, with social activity approaching significance. Conclusions: This study demonstrates the feasibility of CBT interventions to reduce emotional as well as lifestyle risk factors associated with cognitive decline in at-risk older participants. Large studies are needed to evaluate the long-term impact on cognitive decline. The trial was registered with the Australian and New Zealand Clinical Trials Registry (Trial Registration No. ACTRN12618000939291).
Emotion Words Modulate Early Conflict Processing in a Flanker Task: Differentiating Emotion-Label Words and Emotion-Laden Words in Second Language

Emotion words modulate conflict processing, even at an early stage (i.e., N200). However, the previous studies implicitly mixed emotion-label words and emotion-laden words together and mostly concentrated on first language (L1) rather than on second language (L2). The current study aimed to investigate whether L2 negative emotion-label words, negative emotion-laden words, and neutral words would affect conflict processing in a flanker task by using event-related potential (ERP) measurements. Twenty Chinese-English bilinguals completed a modified flanker task to decide the color of the target words. The results revealed that only L2 negative emotion-label words elicited larger left frontal N200 in the incongruent condition than in the congruent condition. No significant difference between the two conditions was observed for L2 negative emotion-laden words or neutral words. This research demonstrated that L2 emotion words could also modulate early conflict processing, at least for L2 negative emotion-label words.