Miracle-dz/UniFAR-FTUs huggingface dataset:
Heart rate variability in atrial fibrillation: The balance between sympathetic and parasympathetic nervous system

Atrial fibrillation (AF) is the commonest abnormal heart rhythm with significant related morbidity and mortality. Several pathophysiologic mechanisms have been advocated to explain the onset of AF. There has been increasing evidence that abnormalities of the autonomic nervous system (ANS) that includes sympathetic, parasympathetic and intrinsic neural network are involved in the pathogenesis of AF. This review will consider the anatomical and pathophysiological concepts of the cardiac neuronal network and discuss how it can be investigated.
CORRELATION OF ORAL HEALTH STATUS WITH GENERAL HEALTH IN ELDERLY LIVING AT RESIDENTIAL HOMES IN GEORGIA.

The aim of the study was to assess oral health status and its correlations with the general health in older adults living in residential houses in Georgia. The study was conducted in 2017-2018 years based on WHO recommendations. The study got approval from bioethical council of National Center for Disease Control and Public Health, protocol #2017-039, 28.06. 2017y. 300 voluntary residents from various residential houses for older people (aged 65 years and more) were observed in regions of Georgia: "Basiliada" (Tbilisi), residential home of municipality of Samtredia, (Imereti), residential home "Carefree old age" (Kakheti). Age groups were divided as following: 65-74; 75-84; 85<. Statistical Package for Social Sciences (SPSS) version 22.0 was used for statistical analysis. DMFT was assessed to be 28.74. Significantly high prevalence of needs of prosthetic treatment 91.1% (p=0.0005), full edentulism 36.2% (p=0.0049), participants with the extraction of more than 20 teeth 81.3% (p=0.0000) and unsatisfactory oral hygiene 39.3% (p=0.0003) were observed. Prevalence of systemic diseases was assessed as the following: cardiovascular disease - 56%, gastroenterologycal diseases - 6%, diabetes - 2.9%, respiratory disease - 8.4%, oncological disease - 6.7%, dementia - 24.2 %. ( p<0.005). Cardiovascular system diseases appeared to be one of the most commonly encountered diseases in dental practice. Based on the study results new program was created "Improve of oral hygiene of older adults living in residential homes in Georgia" in order to increase their access to the dental care, including preventive dental care and improve oral health related quality of life.
Conditional cash transfer and/or lipid-based nutrient supplement targeting the first 1000 d of life increased attendance at preventive care services but did not improve linear growth in young children in rural Mali: results of a cluster-randomized controlled trial.

BACKGROUND In 2014, the World Food Programme added to an ongoing health and nutrition program named "Santé Nutritionnelle à Assise Communautaire dans la région de Kayes" (SNACK), the distribution of cash to mothers and/or lipid-based nutrient supplement (LNS) to children aged 6-23 mo, conditional upon attendance at community health centers (CHCs) during the first 1000 d of life. OBJECTIVE We evaluated the additional impact of the distribution of cash and/or LNS on mean height-for-age z scores (HAZ; primary outcome), stunting (HAZ < -2), and on intermediate outcomes along the program impact pathways. METHODS In a cluster-randomized controlled trial using a 2 × 2 factorial design, 76 CHCs were randomly assigned to deliver either SNACK, SNACK + Cash, SNACK + LNS, or SNACK + Cash + LNS. Cross-sectional surveys among 12- to 42-mo-old children and their mothers were conducted at baseline (2013, n = 5046) and at endline (2016, n = 5098). RESULTS Factorial analysis showed no interaction between cash and LNS treatments for HAZ, but found an antagonistic interaction for stunting (OR: 1.55; 95% CI: 1.05, 2.31; P = 0.03). There were no impacts of the cash, LNS, or cash + LNS treatments, compared with the SNACK alone, on either HAZ or stunting (treatment × time interaction). There were significant impacts of the LNS and cash + LNS treatments on attendance at ≥1 growth monitoring (GM) session (OR: 3.95; 95% CI: 1.69, 9.24; OR: 3.90; 95% CI: 1.73, 8.81, respectively) and half the expected sessions (OR: 4.72; 95% CI: 1.47, 15.17; OR: 5.25; 95% CI: 1.82, 15.11, respectively), mothers' knowledge on importance of GM (OR: 1.98; 95% CI: 1.16, 3.39; OR: 3.12; 95% CI: 1.60, 6.09, respectively), and, only for the LNS group, appropriate timing for complementary feeding (OR: 1.62; 95% CI: 1.09, 2.41). CONCLUSIONS Implementation constraints and suboptimal participation in program activities may explain the lack of impact on child linear growth in this rural region of Mali.This trial was registered at www.isrctn. com as ISRCTN08435964.
Role of blood pressure in mediating carotid artery dilation in response to sympathetic stimulation in healthy, middle-aged individuals.

OBJECTIVES Carotid artery diameter responses to sympathetic stimulation, i.e. carotid artery reactivity (CAR), represents a novel test of vascular health and relates to cardiovascular disease/risk. This study aims to understand the relationship between the increase in blood pressure and carotid artery diameter response during the CAR-test in healthy, middle-aged men. METHODS Sample consisted of 40 normotensive men (aged 31-59) with no history of cardiovascular disease of currently taking medication. Non-invasive ultrasound was used to measure carotid artery diameter during the cold pressor test (CPT), with CAR% being calculated as the relative change from baseline (%). Mean arterial pressure (MAP) was measured with beat-to-beat blood pressure recording. RESULTS CAR% was 4.4±5.4%, peaking at 92±43s. MAP increased from 88±9 mmHg to 110±15 mmHg, peaked at 112±38 seconds, which was significantly later than the diameter peak (P=0.04). The correlation between resting MAP and CAR% was weak (r=0.209 P=0.197). Tertiles based on resting MAP or MAP-increase revealed no significant differences between groups in subject characteristics including age, BMI or CAR% (all P>0.05). Subgroup analysis of individuals with carotid constriction (n=6) versus dilation (n=34), revealed no significant difference in resting MAP or increase in MAP (P=0.209 and 0.272, respectively). CONCLUSION Our data suggests that the characteristic increase in MAP during the CPT does not mediates carotid artery vasomotion.
Risk models and scores for metabolic syndrome: systematic review protocol

Introduction Metabolic syndrome ‘a clustering of risk factors which includes hypertension central obesity, impaired glucose metabolism with insulin resistance and dyslipidaemia’ affects approximately 20%–25% of the global adult population. Individuals with metabolic syndrome have two to threefold risk of developing cardiovascular disease and a fivefold risk of developing developing diabetes and death from all causes. Although there is rapid proliferation of risk scores for predicting the risk of developing metabolic syndrome later in life, yet, these are seldom used in the practice. Therefore, the purpose of this review is to determine the performance of risk models and scores for predicting the metabolic syndrome. Methods and analysis Articles will be sought for from electronic databases (MEDLINE, CINAHL, PubMed and Web of Science) as well as the Cochrane Library. Further manual search of reference lists and grey literatures will be conducted. The search will cover from the start of indexing to 3 October 2018. Identified studies will be included if they fulfil the study selection criteria. Quality of studies will be appraised using suitable criteria for the risk models. The risk scores in the final sample of the review will be ranked/prioritised based on previous quality criteria for prognostic risk models. Lastly, the impact of the models will be ascertained by tracking citations on Google Scholar. Ethics and dissemination This study does not require formal ethical approval as primary data will not be collected. The results will be disseminated through a peer-reviewed publication and relevant conference presentations. PROSPERO registration number CRD42019139326
Alcohol misuse and traumatic brain injury: a review of the potential roles of dopaminergic dysfunction and physiological underarousal post-injury

Abstract Although many researchers have demonstrated an increase in alcohol use following traumatic brain injury (TBI), there is also a body of research indicating that alcohol misuse predisposes one to injury and precedes TBI. Accordingly, various mechanisms have been proposed (e.g., self-medication, dampened levels of arousal, dopaminergic dysfunction, etc.) and variable results have emerged. This paper reviews the empirical evidence, for and against, TBI as a risk factor for alcohol misuse. In particular, this paper focuses on the brain–behavior relationships involved and examines the roles of physiological underarousal and dopaminergic dysfunction in the development of alcohol misuse after injury. Alcohol misuse impedes community reintegration among TBI survivors and creates additional rehabilitative challenges. Thus, in order to inform and improve treatment outcomes among this vulnerable population, a deeper understanding of the neural mechanisms implicated is needed.
Non-medical determinants of perinatal health: protocol for a systematic review with meta-analysis

Introduction Research focusing on the associations between non-medical determinants and unfavourable perinatal health outcomes is increasing. Despite increasing knowledge on this theme, it still remains unclear to what extent social, environmental and lifestyle factors contribute to these unfavourable outcomes. Therefore, we aim to provide a systematic review, preferably with meta-analysis, in order to provide insight into the associations between non-medical determinants and perinatal mortality, preterm birth and being small for gestational age (SGA). Methods and analysis Observational studies performed in European countries studying the associations between non-medical determinants and unfavourable perinatal health outcomes will be included. Primary outcomes of interest are perinatal mortality, preterm birth and SGA. To retrieve potential eligible articles, a systematic literature search was performed in the following online databases on 5 October 2018: MEDLINE, Embase, Web of Science, Cochrane and Google Scholar. Additionally, a reference list check and citation search will be performed. Data of the included articles will be extracted using a standardised and piloted data extraction form. Risk of bias will be assessed using the Newcastle-Ottawa Scale. The study selection and data extraction process will be performed by two reviewers independently. Disagreements will be resolved through discussion with a third reviewer. The pooled effects will be calculated separately for each association found between one of the outcome measures and the non-medical determinants using a random effects model. Heterogeneity of the studies will be assessed using the I2 statistic. Ethics and dissemination No ethical approval is necessary for a systematic review with meta-analysis. The findings will be published in a peer-reviewed journal. PROSPERO registration number CRD42018056105.
TSPO Versus P2X7 as a Target for Neuroinflammation: An In Vitro and In Vivo Study

Neuroinflammation is important in amyotrophic lateral sclerosis (ALS). The P2X7 receptor (P2X7R) is a promising target for neuroinflammation. The objective of this study was to compare 18F-DPA714, a second-generation translocator protein tracer, with 11C-JNJ717, a novel P2X7R tracer, in vitro and in vivo in ALS. Methods: For the in vitro portion of the study, autoradiography with 18F-DPA714 and 11C-JNJ717 was performed on human ALS brain sections in comparison to immunofluorescence with Iba1 and GFAP. For the in vivo portion, 3 male patients with early-stage ALS (59.3 ± 7.2 y old) and 6 healthy volunteers (48.2 ± 16.5 y old, 2 men and 4 women) underwent dynamic PET/MR scanning with 18F-DPA714 and 11C-JNJ717. Volume-of-distribution images were calculated using Logan plots and analyzed on a volume-of-interest basis. Results: Autoradiography showed no difference in 11C-JNJ717 binding but did show increased 18F-DPA714 binding in the motor cortex correlating with Iba1 expression (glial cells). Similar findings were observed in vivo, with a 13% increase in 18F-DPA714 binding in the motor cortex. Conclusion: In symptomatic ALS patients, 18F-DPA714 showed increased signal whereas 11C-JNJ717 was not elevated.
Meimei: An Efficient Probabilistic Approach for Semantically Annotating Tables

Given a large amount of table data, how can we find the tables that contain the contents we want? A naive search fails when the column names are ambiguous, such as if columns containing stock price information are named “Close” in one table and named “P” in another table.One way of dealing with this problem that has been gaining attention is the semantic annotation of table data columns by using canonical knowledge. While previous studies successfully dealt with this problem for specific types of table data such as web tables, it still remains for various other types of table data: (1) most approaches do not handle table data with numerical values, and (2) their predictive performance is not satisfactory.This paper presents a novel approach for table data annotation that combines a latent probabilistic model with multilabel classifiers. It features three advantages over previous approaches due to using highly predictive multi-label classifiers in the probabilistic computation of semantic annotation. (1) It is more versatile due to using multi-label classifiers in the probabilistic model, which enables various types of data such as numerical values to be supported. (2) It is more accurate due to the multi-label classifiers and probabilistic model working together to improve predictive performance. (3) It is more efficient due to potential functions based on multi-label classifiers reducing the computational cost for annotation.Extensive experiments demonstrated the superiority of the proposed approach over state-of-the-art approaches for semantic annotation of real data (183 human-annotated tables obtained from the UCI Machine Learning Repository).
Targeting the Trafficking of Kidney Water Channels for Therapeutic Benefit.

The ability to regulate water movement is vital for the survival of cells and organisms. In addition to passively crossing lipid bilayers by diffusion, water transport is also driven across cell membranes by osmotic gradients through aquaporin water channels. There are 13 aquaporins in human tissues, and of these, aquaporin-2 (AQP2) is the most highly regulated water channel in the kidney: The expression and trafficking of AQP2 respond to body volume status and plasma osmolality via the antidiuretic hormone, vasopressin (VP). Dysfunctional VP signaling in renal epithelial cells contributes to disorders of water balance, and research initially focused on regulating the major cAMP/PKA pathway to normalize urine concentrating ability. With the discovery of novel and more complex signaling networks that regulate AQP2 trafficking, promising therapeutic targets have since been identified. Several strategies based on data from preclinical studies may ultimately translate to the care of patients with defective water homeostasis. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 60 is January 6, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Wireless Sensor Networks (WSNs): New trends in Secure Routing Techniques

Wireless Sensor Networks (WSNs), considered as one of the successfully distributed applications that are currently used to acquire knowledge and collect information from the wirelessly devices seamlessly. The distinctive architecture of WSNs contributed to deploy it in an extensive range of modern industrial applications such as surveillance, monitoring, predicted, and automated control systems which can help in bridging the divide between user requirements and technologies. Moreover, WSNs face several challenges such as Topology control, Robustness, Placement, Power consuming, Scalability, Reliability, Resource Utilization, QoS, Data availability and Security. The main objective of this paper can be classified into two parts; the first one is to illustrate WSNs architecture, applications, challenges, and recent research directions. The second one is highlighting on routing and security design issues, security threats, countermeasures against network layer attacks to achieve secure routing, as the efficiency of the communication process is mainly based on determining the best path between nodes. We also highlight the advantages and performance issues of each secure routing technique. At the end of this paper the possible future research areas are concluded.
The Influence of Temperature and Community Structure on Light Absorption by Phytoplankton in the North Atlantic

We present a model that estimates the spectral phytoplankton absorption coefficient (aph(λ)) of four phytoplankton groups (picophytoplankton, nanophytoplankton, dinoflagellates, and diatoms) as a function of the total chlorophyll-a concentration (C) and sea surface temperature (SST). Concurrent data on aph(λ) (at 12 visible wavelengths), C and SST, from the surface layer (<20 m depth) of the North Atlantic Ocean, were partitioned into training and independent validation data, the validation data being matched with satellite ocean-colour observations. Model parameters (the chlorophyll-specific phytoplankton absorption coefficients of the four groups) were tuned using the training data and found to compare favourably (in magnitude and shape) with results of earlier studies. Using the independent validation data, the new model was found to retrieve total aph(λ) with a similar performance to two earlier models, using either in situ or satellite data as input. Although more complex, the new model has the advantage of being able to determine aph(λ) for four phytoplankton groups and of incorporating the influence of SST on the composition of the four groups. We integrate the new four-population absorption model into a simple model of ocean colour, to illustrate the influence of changes in SST on phytoplankton community structure, and consequently, the blue-to-green ratio of remote-sensing reflectance. We also present a method of propagating error through the model and illustrate the technique by mapping errors in group-specific aph(λ) using a satellite image. We envisage the model will be useful for ecosystem model validation and assimilation exercises and for investigating the influence of temperature change on ocean colour.
The shape of two-dimensional liquid bridges

We have studied a single vertical, two-dimensional liquid bridge spanning the gap between two flat, horizontal solid substrates of given wettabilities. For this simple geometry, the Young–Laplace equation can be solved (quasi-)analytically to yield the equilibrium bridge shape under gravity. We establish the range of gap widths (as described by a Bond number ) for which the liquid bridge can exist, for given contact angles at the top and bottom substrates ( and , respectively). In particular, we find that the absolute maximum span of a liquid bridge is four capillary lengths, for and ; whereas for and no bridge can form, for any substrate separation. We also obtain the minimum value of the cross-sectional area of such a liquid bridge, as well as the conditions for the existence and positions of any necks or bulges and inflection points on its surface. This generalises our earlier work in which the gap was assumed to be spanned by a liquid film of zero thickness connecting two menisci at the bottom and top substrates.
Model organisms at the heart of regeneration

ABSTRACT Heart failure is a major cause of death worldwide owing to the inability of the adult human heart to regenerate after a heart attack. However, many vertebrate species are capable of complete cardiac regeneration following injury. In this Review, we discuss the various model organisms of cardiac regeneration, and outline what they have taught us thus far about the cellular and molecular responses essential for optimal cardiac repair. We compare across different species, highlighting evolutionarily conserved mechanisms of regeneration and demonstrating the importance of developmental gene expression programmes, plasticity of the heart and the pathophysiological environment for the regenerative response. Additionally, we discuss how the findings from these studies have led to improvements in cardiac repair in preclinical models such as adult mice and pigs, and discuss the potential to translate these findings into therapeutic approaches for human patients following myocardial infarction. Summary: This Review discusses the different model organisms used to study cardiac regeneration and their contributions to our understanding of the complex processes that govern regeneration of the heart.
Fabrication of an Efficient Planar Organic-Silicon Hybrid Solar Cell with a 150 nm Thick Film of PEDOT: PSS

Organic–inorganic hybrid solar cells composed of p-type conducting polymer poly (3,4-ethylene-dioxythiophene): polystyrenesulfonate (PEDOT: PSS) and n-type silicon (Si) have gained considerable interest in recent years. From this viewpoint, we present an efficient hybrid solar cell based on PEDOT: PSS and the planar Si substrate (1 0 0) with the simplest and cost-effective experimental procedures. We study and optimize the thickness of the PEDOT: PSS film to improve the overall performance of the device. We also study the effect of ethylene glycol (EG) by employing a different wt % as a solvent in the PEDOT: PSS to improve the device’s performance. Silver (Ag) was deposited by electron beam evaporation as the front and rear contacts for the solar cell device. The whole fabrication process was completed in less than three hours. A power conversion efficiency (PCE) of 5.1%, an open circuit voltage (Voc) of 598 mV, and a fill factor (FF) of 58% were achieved.
Real-time path tracing of small scenes using WebGL

Monte Carlo path tracing is becoming increasingly viable as a method for rendering global illumination in real-time. We explored the potential of using path-tracing and WebGL to rendering real-time 3D graphics in a web browser. The project focused on rendering small scenes where objects are dynamically translated, rotated, and scaled. We examined the performance of various acceleration data structures (ADS) including 3D grids, irregular grids, and bounding volume hierarchies. To reduce the noise inherent in path-traced images, we separated the lighting into several lighting terms and applied an A-Trous wavelet filter on each term. We explored both the results of splitting the direct and indirect lighting terms and splitting the glossy and diffuse terms. We also applied the surface albedo in a post-processing step to better retain texture details. On small scenes, we were able to trace 720x540 pixel images at interactive framerates, i.e. above 10hz, at one sample per pixel with a maximum path depth of five. Using per-object bounding volume hierarchies, we can render dynamically changing scenes, e.g. moving objects, at interactive framerates. The noise reduction filter executes in less than 10 milliseconds and is successful at removing noise but over-blurs some image details and introduces some artefacts. We conclude that while real-time path tracing is possible WebGL, there are several caveats of the current version of the WebGL library that makes some state-of-the-art optimisation techniques impractical. For future work, we suggest several approaches for improving the path tracer. For instance, extending the noise reduction filter with temporal accumulation and anti-aliasing, and optimising the encoding of triangles and ADS nodes.