Miracle-dz/UniFAR-FTUs huggingface dataset:
Heterogenous Graph Embeddings of Electronic Health Records Improve Critical Care Disease Predictions

Electronic Health Record (EHR) data is a rich source for powerful biomedical discovery but it consists of a wide variety of data types that are traditionally diﬃcult to model. Furthermore, many machine learning frameworks that utilize these data for predictive tasks do not fully leverage the inter-connectivity structure and therefore may not be fully optimized. In this work, we propose a relational, deep heterogeneous network learning method that operates on EHR data and addresses these limitations. In this model, we used three diﬀerent node types: patient, lab, and diagnosis. We show that relational graph learning naturally encodes structured relationships in the EHR and outperforms traditional feed forward models in the prediction of thousands of diseases. We evaluated our model on the EHR data derived from MIMIC-III, a public critical care data set, and show that our model has improved prediction of numerous diagnosis.
Offensive and Defensive Perspectives in Additive Manufacturing Security

Additive Manufacturing (AM) is transforming the manufacturing industry by reducing prototyping time and easing the production of complex parts. Notably, use of AM has gained traction in the medical and aerospace fields, and is rapidly increasing in usage in traditional industry. However, AM’s cyberphysical nature opens systems up to vulnerabilities that can result in both cyber and physical damage. In this paper, we document and categorize the state of the art in Additive Manufacturing security research in three ways by using Microsoft’s Spoofing, Tampering, Repudiation, Information Disclosure, Denial of Service and Elevation of Privilege (STRIDE) threat model, by the intent of the attacker, and by the overall purpose of the published works. We also provide a list of security recommendations for AM that could aid in the design of secure AM systems. We hope our approach will enable an understanding of AM security from both the attacker’s and defender’s perspective, and serve as a survey of relevant research in the field, and stimulate more research into securing AM systems. Keywords–additive manufacturing; cybersecurity; threat modeling.
Genetic variation in Artemisia campestris : do distinct genetic varieties exist within the species ? Lab Report NFGEL Project # 319

Project submitted by Andrew Bower, Area Geneticist US Forest Service 1835 Black Lake Blvd. SW Olympia, WA 98512 p: 360-956-2405 abower@fs.fed. us Mark Skinner, Regional Botanist US Forest Service Region 6 Regional Office 1220 SW 3 Avenue Portland, OR 97204 p: 503-808-2150 mskinner02@fs.fed. us Theodore B. Thomas, Ecologist Pacific Region, Washington Fish and Wildlife Office Branch of Listing, Critical Habitat 510 Desmond Drive SE, suite 102 Lacey, WA 98501 p: 360-753-4327 ted_thomas@fws.gov
CIRIC TYPE P-CYCLIC CONTRACTION RESULTS FOR DISCONTINUOUS MAPPINGS

Cyclic mappings constitute a recently introduced class of mappings which have appeared in a number of papers in the contexts of fixed point theory and in the theory of optimization. In this paper we consider p-cyclic contraction type mappings which are generalized cyclic contractions through p number of subsets of a probabilistic metric space. Moreover the contractive mappings are discontinuous. We use Hadzic type t-norms in our theorems which is characterized by the equicontinuities of its iterates. We deduce two fixed point theorems. In one of the theorems we use a control function which is the counterpart of a function widely used in fixed point theory in metric spaces. The theorems are supported with examples. The work is in the line of research developing probabilistic fixed point theory.
Prediction of Obsessive-compulsive Symptoms Based on Negative Affect, Rumination, and Dispositional Mindfulness

Obsessive-compulsive symptoms could be an important background for clinical disorder of OCD. The role of negative affect, rumination, and dispositional mindfulness has not been investigated in previous researches. Therefore, the purpose of this study was to study the relationship among negative affect, rumination, dispositional mindfulness with obsessive-compulsive symptoms. In a descriptive-correlational and crosses- sectional study, 283 students from University of Tabriz have selected by available sampling method during April through May 2017.Maudsley OCD inventory, Positive affect and negative affect scale (PANAS), Five Facet Mindfulness Questionnaire (FFMQ) and Rumination Scale of the Response Styles Questionnaire were used for collecting the data. Data were analyzed using Pearson correlation and multiple Regressions tests. The results showed that correlation between obsessive-compulsive symptoms and dispositional mindfulness was negative and significant, correlation between obsessive-compulsive symptoms and negative affect was positive and significant and correlation between obsessive-compulsive symptoms and rumination was significant. Also, negative affect, rumination, and dispositional mindfulness did able to predict the obsessive-compulsive symptoms. Dispositional mindfulness, negative affect, and rumination are the important determinants of obsessive-compulsive symptoms.
Megacystis Microcolon Intestinal Hypoperistalsis Syndrome-A Rare Case

Case Report Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (MMIHS) is a quite rare congenital and fatal disease which was firstly defined by Berdon and colleagues in 1976 [1] and is often underdiagnosed and confused with other disorders. The clinicians priority is to be make a correct diagnosis. It predominantly affects females (4:1 ratio) and is characterized by the presence of distended bladder (without distal urinary tract obstruction), microcolon, and decreased or absent intestinal peristalsis. We present a case of female newborn with antenatal ultrasound revealing a large cystic mass in pelvis of urinary tract origin, abdominal distension, aperistalsis of the intestine and micro colon. Gastrostomy and vesicostomy was done. Pathological findings of small bowel biopsy revealed normal ganglion cells. Child died of septicaemia at age of 20 days.
New Insights Into the Nature of Interspecific Hybrid Sterility in Rice

Interspecific and intraspecific hybrid sterility is a typical and common phenomenon of postzygotic reproductive barrier in rice. This is an indicator of speciation involved in the formation of new species or subspecies, and it significantly hampers the utilization of favorable genes from distant parents for rice improvement. The Oryza genus includes eight species with the same AA genome and is a model plant for studying the nature of hybrid sterility and its relationship with speciation. Hybrid sterility in rice is mostly controlled by nuclear genes, with more than 50 sterility loci genetically identified to date, of which 10 hybrid sterility loci or pairs were cloned and characterized at the molecular level. Comparing the mapping results for all sterility loci reported indicated that some of these loci from different species should be allelic to each other. Further research revealed that interactions between the multiple alleles at the hybrid sterility locus caused various genetic effect. One hypothesis for this important phenomenon is that the hybrid sterility loci are orthologous loci, which existed in ancient ancestors of rice. When one or more ancestors drifted to different continents, genetic divergence occurred because of adaptation, selection, and isolation among them such that various alleles from orthologous loci emerged over evolutionary time; hence, interspecific hybrid sterility would be mainly controlled by a few orthologous loci with different alleles. This hypothesis was tested and supported by the molecular characterization of hybrid sterility loci from S1, S5, Sa, qHMS7, and S27. From this, we may further deduce that both allelic and non-allelic interactions among different loci are the major genetic basis for the interspecific hybrid sterility between O. sativa and its AA genome relatives, and the same is true for intraspecific hybrid sterility in O. sativa. Therefore, it is necessary to raise the near-isogenic lines with various alleles/haplotypes and pyramided different alleles/haplotypes from sterile loci in the same genetic background aiming to study allelic and non-allelic interaction among different hybrid sterility loci in the AA genome species. Furthermore, the pyramiding lines ought to be used as bridge parents to overcome hybrid sterility for rice breeding purposes.
Transcriptional Programs Underlying Cold Acclimation of Common Carp (Cyprinus carpio L.)

Properly regulated transcriptional responses to environmental perturbations are critical for the fitness of fish. Although gene expression profiles in the tissues of common carp upon cold stress were previously characterized, the transcriptional programs underlying cold acclimation are still not well known. In this study, the ability of three common carp strains including Hebao red carp (HB), Songpu mirror carp (SPM) and Yellow river carp (YR) to establish cold resistance after acclimation to a mild hypothermia stress at 18°C for 24 h was confirmed by measurements of the critical thermal minimums (CTMin). The gene expression profiles of the brain and the heart from these strains under both control and cold-acclimated conditions were characterized with RNA-sequencing. The data of the three common carp strains with different genetic background were combined in the differential gene expression analyses to balance the effects of genetic diversity on gene expression. Marked effects of tissue origins on the cold-induced transcriptional responses were revealed by comparing the differentially expressed gene (DEG) lists of the two tissues. Functional categories including spliceosome and RNA splicing were highly enriched in the DEGs of both tissues. However, steroid biosynthesis was specifically enriched in DEGs of the brain and response to unfolded protein was solely enriched in DEGs of the heart. Consistent with the up-regulation of the genes involved in cholesterol biosynthesis, total cholesterol content of the brain was significantly increased upon cold stress. Moreover, cold-induced alternative splicing (AS) events were explored and AS of the rbmx (RNA-binding motif protein, X chromosome) gene was confirmed by real-time quantitative PCR. Finally, a core set of cold responsive genes (CRGs) were defined by comparative transcriptomic analyses. Our data provide insights into the transcriptional programs underlying cold acclimation of common carp and offer valuable clues for further investigating the genetic determinants for cold resistance of farmed fish.
Telepsychiatry During the COVID-19 Pandemic: Development of a Protocol for Telemental Health Care

Background The rapid spread of the Coronavirus disease 2019 (COVID-19) has forced most countries to take drastic public health measures, including the closure of most mental health outpatient services and some inpatient units. This has suddenly created the need to adapt and expand telepsychiatry care across the world. However, not all health care services might be ready to cope with this public health demand. The present study was set to create a practical and clinically useful protocol for telemental health care to be applied in the context of the current COVID-19 pandemic. Methods A panel of psychiatrists from 15 different countries [covering all World Health Organization (WHO) regions] was convened. The panel used a combination of reactive Delphi technique and consensus development conference strategies to develop a protocol for the provision of telemental health care during the COVID-19 pandemic. Results The proposed protocol describes a semi-structured initial assessment and a series of potential interventions matching mild, moderate, or high-intensity needs of target populations. Conclusions Telemedicine has become a pivotal tool in the task of ensuring the continuous provision of mental health care for the population, and the outlined protocol can assist with this task. The strength of this protocol lies in its practicality, clinical usefulness, and wide transferability, resulting from the diversity of the consensus group that developed it. Developed by psychiatrists from around the globe, the proposed protocol may prove helpful for many clinical and cultural contexts, assisting mental health care providers worldwide.
Thioredoxin Network in Plant Mitochondria: Cysteine S-Posttranslational Modifications and Stress Conditions

Plants are sessile organisms presenting different adaptation mechanisms that allow their survival under adverse situations. Among them, reactive oxygen and nitrogen species (ROS, RNS) and H2S are emerging as components not only of cell development and differentiation but of signaling pathways involved in the response to both biotic and abiotic attacks. The study of the posttranslational modifications (PTMs) of proteins produced by those signaling molecules is revealing a modulation on specific targets that are involved in many metabolic pathways in the different cell compartments. These modifications are able to translate the imbalance of the redox state caused by exposure to the stress situation in a cascade of responses that finally allow the plant to cope with the adverse condition. In this review we give a generalized vision of the production of ROS, RNS, and H2S in plant mitochondria. We focus on how the principal mitochondrial processes mainly the electron transport chain, the tricarboxylic acid cycle and photorespiration are affected by PTMs on cysteine residues that are produced by the previously mentioned signaling molecules in the respiratory organelle. These PTMs include S-oxidation, S-glutathionylation, S-nitrosation, and persulfidation under normal and stress conditions. We pay special attention to the mitochondrial Thioredoxin/Peroxiredoxin system in terms of its oxidation-reduction posttranslational targets and its response to environmental stress.
White-light endoscopy versus magnifying narrow-band imaging for diagnosis of the histological subtype of gastric cancer

Objective: Distinguishing undifferentiated-type (diffuse-type) from differentiated-type (intestinal-type) cancer is crucial for determining the indication of endoscopic resection for gastric cancer. This study aimed to evaluate on-site diagnostic performance of conventional white-light endoscopy (WLE) and magnifying narrow-band imaging (M-NBI) in determining the subtype of gastric cancer. Design: We conducted a multicenter prospective single-arm trial. Patients who planned to undergo treatment for histologically proven cT1 gastric cancer were recruited from six tertiary care institutions. The primary and key secondary endpoints were diagnostic accuracy and specificity, respectively. The diagnostic algorithm of WLE was based on lesion color. The M-NBI algorithm was based on the microsurface and microvascular patterns. Results: A total of 208 patients were enrolled. After protocol endoscopy, 167 gastric cancers were included in the analysis. The accuracy, sensitivity, specificity, and positive likelihood ratio of WLE for undifferentiated-type cancer were 80% (95% CI 73%-86%), 69% (53%-82%), 84% (77%-90%), and 4.4 (2.8-7.0), respectively. Those of M-NBI were 82% (75%-88%), 53% (38%-68%), 93% (87%-97%), and 7.2 (3.6-14.4), respectively. There was no significant difference in accuracy between WLE and M-NBI (p = 0.755), but specificity was significantly higher with M-NBI than with WLE (p = 0.041). Those of M-NBI combined with WLE were 81% (74%-87%), 38% (24%-54%), 97% (92%-99%), and 11.5 (4.1-32.4), respectively. Conclusion: M-NBI is more specific than WLE in distinguishing undifferentiated-type from differentiated-type gastric cancer and M-NBI combined with WLE is highly reliable (positive likelihood ratio >10). Trial registration number UMIN000032151.
Insights Into the Spatiotemporal Patterns of Complexity of Ventricular Fibrillation by Multilead Analysis of Body Surface Potential Maps

Background Ventricular fibrillation (VF) is the main cause of sudden cardiac death, but its mechanisms are still unclear. We propose a noninvasive approach to describe the progression of VF complexity from body surface potential maps (BSPMs). Methods We mapped 252 VF episodes (16 ± 10 s) with a 252-electrode vest in 110 patients (89 male, 47 ± 18 years): 50 terminated spontaneously, otherwise by electrical cardioversion (DCC). Changes in complexity were assessed between the onset (“VF start”) and the end (“VF end”) of VF by the nondipolar component index (NDIBSPM), measuring the fraction of energy nonpreserved by an equivalent 3D dipole from BSPMs. Higher NDI reflected lower VF organization. We also examined other standard body surface markers of VF dynamics, including fibrillatory wave amplitude (ABSPM), surface cycle length (BsCLBSPM) and Shannon entropy (ShEnBSPM). Differences between patients with and without structural heart diseases (SHD, 32 vs. NSHD, 78) were also tested at those stages. Electrocardiographic features were validated with simultaneous endocardium cycle length (CL) in a subset of 30 patients. Results All BSPM markers measure an increase in electrical complexity during VF (p < 0.0001), and more significantly in NSHD patients. Complexity is significantly higher at the end of sustained VF episodes requiring DCC. Intraepisode intracardiac CL shortening (VF start 197 ± 24 vs. VF end 169 ± 20 ms; p < 0.0001) correlates with an increase in NDI, and decline in surface CL, f-wave amplitude, and entropy (p < 0.0001). In SHD patients VF is initially more complex than in NSHD patients (NDIBSPM, p = 0.0007; ShEnBSPM, p < 0.0001), with moderately slower (BsCLBSPM, p = 0.06), low-amplitude f-waves (ABSPM, p < 0.0001). In this population, lower NDI (p = 0.004) and slower surface CL (p = 0.008) at early stage of VF predict self-termination. In the NSHD group, a more abrupt increase in VF complexity is quantified by all BSPM parameters during sustained VF (p < 0.0001), whereas arrhythmia evolution is stable during self-terminating episodes, hinting at additional mechanisms driving VF dynamics. Conclusion Multilead BSPM analysis underlines distinct degrees of VF complexity based on substrate characteristics.
Proteins of Developing Worker Honey Bees, Apis mellifera, ,

The fluid proteins of the honey bee, Apis mellifera L. , have not been examined extensively. Liu and Dixon (1965) separated hemolymph proteins of worker and queen larvae, and Martin (1965) similarly investigated the hemolymph of adult worker bees. Lensky (1967) reported separation by paper electrophoresis of egg homogenates, 5-day-old larvae, prepupae, 2-day-old pupae, 6-day-old pupae, emerging adult workers, and adult field bees. Recently, hemolymph proteins of adult queens and drones were separated by disc electrophoresis (Lensky and Alumot 1969).
An Intramuscular Injection of Mixed Testosterone Esters Does Not Acutely Enhance Strength and Power in Recreationally Active Young Men

Purpose: Limited data are available on the acute performance-enhancing effects of single-dose administration of testosterone in healthy humans. Studies of testosterone administrations to healthy humans are rare due to the difficult nature and necessity of close clinical monitoring. However, our unique physiological experimental facilities combined with close endocrinological collaboration have allowed us to safely complete such a study. We tested the hypothesis that an intramuscular injection of 250 mg mixed testosterone esters (TEs) enhances physical performance in strength and power exercises acutely, measured 24 h after injection. Additionally, we investigated whether the basal serum testosterone concentration influences the performance in countermovement jump (CMJ), 30-s all out cycle sprint, and one-arm isometric elbow flexion. Methods: In a randomized, double-blind, placebo-controlled design, 19 eugonadal men received either a TE (n = 9, 23 ± 1 years, 183 ± 7 cm, 83 ± 10 kg) or a PLA (n = 10, 25 ± 2 years, 186 ± 6 cm, 82 ± 14 kg) injection. Hormonal levels and the performance in CMJ, 30-s all out cycle sprint, and one-arm isometric elbow flexion were measured before and 24 h after injection. Results: Firstly, an intramuscular injection of 250 mg mixed TEs did not enhance the vertical jump height in a CMJ test, peak power, mean power, and fatigue index in a 30-s all-out cycle sprint or rate of force development and maximal voluntary contraction in a one-arm isometric elbow flexion 24 h post-injection. Secondly, baseline testosterone levels appeared not to influence performance in strength and power exercises to a large extent in healthy, recreationally active young men. Conclusion: A single intramuscular injection of 250 mg mixed TEs has no acute ergogenic effects on strength and power performance in recreationally active, young men. This novel information has implication for basic physiological understanding. Whether the same applies to an elite athlete population remains to be determined. If so, this would have implications for anti-doping efforts aiming to determine the most cost-efficient testing programs.
Tick Salivary Compounds for Targeted Immunomodulatory Therapy

Immunodeficiency disorders and autoimmune diseases are common, but a lack of effective targeted drugs and the side-effects of existing drugs have stimulated interest in finding therapeutic alternatives. Naturally derived substances are a recognized source of novel drugs, and tick saliva is increasingly recognized as a rich source of bioactive molecules with specific functions. Ticks use their saliva to overcome the innate and adaptive host immune systems. Their saliva is a rich cocktail of molecules including proteins, peptides, lipid derivatives, and recently discovered non-coding RNAs that inhibit or modulate vertebrate immune reactions. A number of tick saliva and/or salivary gland molecules have been characterized and shown to be promising candidates for drug development for vertebrate immune diseases. However, further validation of these molecules at the molecular, cellular, and organism levels is now required to progress lead candidates to clinical testing. In this paper, we review the data on the immuno-pharmacological aspects of tick salivary compounds characterized in vitro and/or in vivo and present recent findings on non-coding RNAs that might be exploitable as immunomodulatory therapies.
Foot-and-Mouth Disease Outbreak at Bageshwori Gaushala, Chitwan, Nepal

Cow being the national animal of Nepal has special place in the society. Religious institutions have since prehistoric time reared and cared for cattle herds and the tradition still continues. The Bageshwori Gaushala (cow shelter), initiated by the Hindu Rastraguru Yogi Narhaharinath in mid-1990s is one of the largest of such nucleus indigenous cattle herds in Nepal. Indigenous cattle conservation strategy of Nepal has recognized the importance of this nucleus herd, kept by grazing in the surrounding forest. Ethnoveterinary approaches of managing the herd health is in practice and vaccination was never done. Occasional outbreak did happen in past but overall the herd never suffered severe impact. In April 2018, an outbreak of foot-and-mouth disease (FMD) occurred at Bageshwori, Gaushala, Devghat, Bharatpur Metropolitan-1, Chitwan district of Nepal. In the bovine herd studied, 80 (53.33%) out of 150 affected animals presented characteristics FMD symptoms as vesicular lesions, drooling salivation, foot lameness, high fever and weakness. Following prompt supportive treatment, the condition improved. The complete recovery of infected herd was observed after 45 d. Laboratory analysis showed the presence of Aphthovirus serotype O in the clinical sample. The present study attempts to provide fresh insights into the recent FMD outbreak, clinical signs, their effective treatment protocol and preventive measures that must be practiced following FMD outbreak.