Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuropsychiatric Aspects of Healthy Aging: an Epidemiological Approach : Neuropsychiatrische aspecten van gezond ouder worden: een epidemiologische benadering

markdownabstractAgeing is becoming a significant global challenge which will require economic and social adjustments. Aging causes morphological changes in the brain associated with increased prevalence and incidence of neuropsychiatric diseases, mostly depression, Alzheimer’s Disease (AD) and Parkinson’s disease (PD). Neuropsychiatric diseases impair quality of life and pose a high economic burden to individuals and society. Thus, in order to better face these challenging diseases, it is of importance to understand factors that could contribute in their pathophysiology. It is now widely accepted that there is a strong genetic component in the development of neurodegenerative diseases, whereas emerging evidence is indicating also epigenetic mechanisms such as DNA methylation and histone acetylation as key players in the development of AD and PD. Also, women due to longer lifespans and unique risk factors, face the highest burden of these diseases, especially in menopausal years where major hormonal changes, such as a sharp decrease in estradiol, occur. To improve women’s neuropsychiatric health after menopause, estrogen receptorβ has been suggested as a novel target therapy for prevention and treatment of neuropsychiatric diseases. Further, alcohol misuse among elderly is on the rise and elderly women are particularly vulnerable to the adverse effects of alcohol, and alcohol use disorders in this subgroup are often overlooked or misdiagnosed. Also, elderly person has an increasing chance of a traumatic death of a loved one. An estimated 10-20% of bereaved people continue to grieve for a prolonged period. This complex condition is termed as Prolonged Grief Disorder (PGD), which can have a severe influence on the quality of life as it impairs daily functioning and sleep and may increase the risk of certain diseases. Our insight of the association between the dynamics of grieving process and overall health outcomes is still insufficient. The aim of the thesis was to identify factors associated with neuropsychiatric disorders among the elderly. The first objective of the thesis was to identify epigenetic as well as women-specific factors that can play a role in the development of neuropsychiatric outcomes with emphasize on neurodegenerative diseases and alcoholism. A second objective was to identify the impact of grief and complicated grief on cortisol secretion, sleep pattern, and overall quality of life, as well as to identify factors associated with grief persistence.
Mediastinal lymphadenectomy for thymic malignancies: the time has come

In a recent issue of the Journal of Thoracic and Cardiovascular Surgery , Dr. Wentao Fang and Colleagues reported the results of a prospective observational trial concerning intentional lymphadenectomy during thymectomy for thymic malignancies on 275 patients (1). This remarkable study was devised and developed by the Chinese Alliance for Research in Thymomas (ChART) and follows a retrospective study on 1,617 patients (2).
"We were our parents' ears and mouths:" Reflecting on the language-brokering experiences of hearing children born to Deaf-parents.

Background. Hearing children born to deaf parents, or children of deaf adults (CODAs), are often bicultural and bilingual members of the deaf and hearing communities. They are often expected to fulfil very adult roles, especially as the communication link between their deaf parents and the hearing society. Assuming adult roles may place CODAs in difficult situations, potentially affecting their wellbeing and development. In SA, little is known about CODAs and the dynamics of growing up hearing in deaf-parented homes. Objective. To reflect on the childhood experiences of language brokering in deaf-parented families. Methods. Two male and eight female participants (21 - 40 years), identified through purposive and snowball sampling, participated in this study. A phenomenological, qualitative approach was employed using semi-structured, open-ended interviews. Thematic analysis revealed inductive themes. Results. The findings indicate that the interviewed CODAs acted as language brokers and interpreters between their families and the hearing community from a very young age. As children, they were placed in demanding situations, for which they were not developmentally ready. CODAs found balancing the demands from both communities emotionally draining, especially at a young age. Conclusion. A multidisciplinary approach is suggested to address the mental health, wellbeing and development of young CODAs.
Kinesiology taping for breast lymphoedema after breast cancer treatment: A feasibility randomised controlled trial

Title Kinesiology taping for breast lymphoedema after breast cancer treatment: A feasibility randomised controlled tria Author(s) Collins, Siobhán; Bradley, Nora; Fitzgibbon, Sarah; McVeigh, Joseph G. Publication date 2018-07-17 Original citation Collins, S. , Bradley, N. , Fitzgibbon, S. and McVeigh, J. G. (2018) 'Kinesiology taping for breast lymphoedema after breast cancer treatment: A feasibility randomised controlled trial', Physiotherapy Practice and Research, 39(2), pp. 107-116. Type of publication Article (peer-reviewed) Link to publisher's version http://dx.doi. org/10.3233/PPR-180113 Access to the full text of the published version may require a subscription. Rights © 2018 IOS Press and the authors. Item downloaded from http://hdl.handle. net/10468/7811
Mechanisms of Atrial Tachyarrhythmias Associated With Coronary Artery Occlusion in a Chronic Canine Model

Background—Coronary artery disease predisposes to atrial fibrillation (AF), but the effects of chronic atrial ischemia/infarction on AF-related substrates are unknown. Methods and Results—Regional right atrial myocardial infarction (MI) was created in 40 dogs by ligating an artery that supplies the right atrial free wall and not the ventricles; 35 sham dogs with the same artery isolated but not ligated were controls. Dogs were observed 8 days after MI and subjected to open-chest study, in vitro optical mapping, and/or cell isolation for patch-clamp and Ca2+ imaging on day 8. Holter ECGs showed more spontaneous atrial ectopy in MI dogs (eg, 662±281 on day 7 versus 34±25 ectopic complexes per day at baseline; 52±21 versus 1±1 atrial tachycardia episodes per day). Triggered activity was increased in MI border zone cells, which had faster decay of caffeine-evoked Ca2+ transients and enhanced (by ≈73%) Na+-Ca2+ exchange current. Spontaneous Ca2+ sparks (confocal microscopy) occurred under β-adrenergic stimulat.
Comparative Study of Metachromatic Staining Methods in Assessing the Exfoliative Cell Types During Oestrous Cycle in Sprague-Dawley Laboratory Rats

This study was aimed at comparing the commonly used metachromatic stains viz., Papanicolaou stain, WrightGiemsa, Toluidine blue and Methylene blue in the assessment of cell types of the oestrous cycle in rats. Eight female Sprague-D awley rats aged 8-9 weeks were used for this assessment. Cotton Swabs were gently inserted in the animals vagina to obtain cells from which they were then transferred to glass slides for staining and evaluation under microscopy. The different cell types were compared for their morphological features and clarity of cellular detail under all four stains. The application, advantages and limitations of all stains were then discussed. It was concluded that the selection of the most effective stain in the assessment of vaginal cytology depends o n their application to clinical or research which was based on the cellular detail of interest, time, cost and availability of each sta ining procedure.
Evaluating the impact of point-of-care ultrasonography on patients with suspected acute heart failure or chronic obstructive pulmonary disease exacerbation in the emergency department: A prospective observational study.

OBJECTIVES Acute heart failure and chronic obstructive pulmonary disease (COPD) are sometimes difficult to differentiate in the emergency department (ED). We sought to determine the clinical impact of point-of-care ultrasonography (POCUS) in ED patients with suspected acute heart failure or COPD. METHODS We conducted a prospectively collected cohort study with health records review with frequency matching at The Ottawa Hospital between March and September 2017. We included patients aged 50 and older with shortness of breath or cough from suspected acute heart failure or COPD. Our primary outcome was ED length of stay. Secondary outcomes were time to disposition decision, time to appropriate treatment, and the incidence of adverse events. We analyzed time-to-event outcomes using Kaplan-Meier analysis and Cox regression analysis with POCUS analyzed as a time-dependent variable, and the incidence of adverse events using logistic regression analyses. RESULTS There were 81 patients evaluated with lung POCUS and 243 matched patients who were not. Lung POCUS was not significantly associated with ED length of stay and time to disposition decision; however, patients evaluated with lung POCUS received disease-specific treatment faster compared with the non-POCUS group (adjusted hazard ratio, 1.50 [95% confidence interval, 1.05-2.15], a median time difference of 31 minutes). We found no significant differences in the incidence of adverse events. CONCLUSIONS In this study, use of lung POCUS resulted in no difference in ED length of stay and time to disposition decision, but was associated with faster administration of disease-specific treatments for elderly patients with suspected acute heart failure or COPD.
Integrative Care Models: Impact on an Aging Society Chelsea Rink

This paper explores the need for healthcare reform to support the aging unique needs of the aging population and explores the application of integrated care models in achieving the healthcare Triple Aim. Two alternative integrated care models for older adults in the United States are examined: the Program of All-Inclusive Triple Aim are introduced and utilized to evaluate and compare PACE and Tandem integrated care models, and the need for further research of this topic.
Conscience

and adherents to a faith or " cult," the cult of "helping the helpless and comforting and healing the sick. " The mere sound of the words moves the heart. Those who not only admire the motto of the cult, but give themselves up enthusiastically to the practice of its faith, are like other religious enthusiasts, they feel an intense desire to make converts and an equal eagerness to raise the tone and character of their associates on the peculiar lines and principles of the "Cult. Now, whether the cult of " helping the helpless and comforting and healing the sick " be regarded as a religion in itself, or as a part of Christianity, or of the " Religion of Humanity," in either case it is a rational, a useful, and a noble faith. It offers no niarks for the arrows of the sceptic, no insoluble
Okul Çağındaki Çocuklarda Demir, Çinko ve A Vitamini Eksikliği Prevalansının Değerlendirilmesi

Amac: Demir, cinko ve A vitamini toplum sagligi acisindan onemli mikrobesinlerdir. Bu uc mikrobesin organizmada hucre bolunme ve farklilasmasinda, immunitede, kemik gelisiminde, gorme, zeka ve algilama fonksiyonunda, anne ve cocuk mortalitesinde etkilidir. Calismada, saglikli cocuklarda serum demir, cinko ve A vitamini eksikligi prevalansini ve eksikliklerinin birbiriyle olan iliskisini arastirdik. Gerec ve Yontemler: Calismamizda Bulent Ecevit Universitesi Tip Fakultesi Genel Cocuk Poliklinigi’ne basvuran 6-14 yas arasindaki 174 kiz, 160 erkek olmak uzere toplam 334 saglikli cocukta serum demir, cinko, A vitamini degerleri ve tam kan sayimi calisildi. Bulgular: Demir eksikligi prevalansi %49.7, cinko eksikligi prevalansi %18.9, A vitamini eksikligi prevalansi %14.7 saptandi. Serum demir, cinko ve A vitamini duzeyleri arasinda istatistiksel olarak anlamli iliski saptanmadi. Demir eksikligi olan ve olmayan olgular arasinda cinko veya A vitamini eksikligi acisindan istatistiksel olarak anlamli fark saptanmadi. Kizlar ve erkekler arasinda demir ve A vitamini eksikligi acisindan istatistiksel olarak anlamli fark saptanmadi. Cinko eksikligi ise kizlarda %23.6 (n=41), erkeklerde %13.8 (n=22) olarak bulunmus olup aradaki fark istatistiksel olarak anlamli saptandi (p=0.022). Sonuc: Saglam cocuklarda bile demir, cinko ve A vitamini eksikliginin onemli boyutlarda oldugu gorulmektedir. Ozellikle demir eksiligi yurutulen calismalara, programlara ragmen halen yuksek oranlarda seyretmektedir. Turkiye’de mikrobesin eksikliklerin sikliginin belirlenebilmesi icin yeterli olgu sayisi ile degisik ozellikte toplum orneklerinin incelenmesine ihtiyac vardir.
Management of non-healing wounds with honey dressings: a literature review

Aim: The aim of the literature review was to identify the effectiveness of products containing honey in the management of non-healing wounds. Design: A literature review. Methods: Based on predefined criteria, studies were searched in the electronic databases PubMed, Science Direct, EBSCO and Google Scholar between 2007 and 2017. Using the PRISMA recommendations, twenty studies were selected and analyzed. Results: Studies assessed in the review investigated the mean wound healing time, number (percentage) of completely or partly healed cases, pain intensity, odor and antibacterial activity of honey. Most frequently, the efficiency of honey was assessed in diabetic and lower leg ulcers, with wounds of varied etiology being investigated in the majority of studies. The outcomes of most studies showed a shorter mean healing time, higher percentages of completely healed wounds and more effective eradication of wound infection. Only three studies reported no significant improvement in the treatment of lower leg and diabetic ulcers and malignant wounds with honey. Conclusion: Honey is an effective substance in the management of wounds and may be used at any phase of healing for any types of wounds providing that the patient's allergies to some components of dressings are ruled out.
An exploration of factors influencing patient outcomes of psychiatric genetic counseling

Though understanding how different characteristics of the patient and session influence outcomes of genetic counseling (GC) is important, little research data currently exits on this topic. We conducted a retrospective review of charts from patients who attended a specialist psychiatric GC clinic between February 1, 2012 and January 31, 2017. We extracted data to explore the effects of patient and sessionrelated variables on Genetic Counseling Outcome Scale scores (GCOS, validated instrument that measures empowerment). We used ANOVA to analyze the pre-, to one-month post-GC change in GCOS scores in relation to eleven variables. 307 charts were included in analysis. Overall, GCOS scores significantly increased after GC (p<0.0005). No significant differences in GCOS change scores were identified with respect to: sex, ethnicity, diagnosis, mode of referral, type of appointment, genetic counseling student involvement, presence of observers or personal/family history of mental illness. Significant relationships were found between GCOS change scores and mode of delivery of GC (p=0.048, h2 = 0.020) and primary indication for the appointment (understanding recurrence risk versus other, p=0.001, h2 = 0.037). This exploratory study provides the first data on how a number of characteristics of the patient and session influence outcomes of genetic counseling. Understanding the patient and session-related factors that do seem to influence outcomes may allow for adjustment of service delivery strategies to promote the best possible outcomes.
Sensory processing and cognitive development of preterm and full term infants

Introducao: Estudos atuais apontam para as repercussoes que as alteracoes de processamento sensorial trazem para o desenvolvimento neuropsicomotor infantil. Pouco se conhece sobre a influencia dessas alteracoes no desenvolvimento cognitivo de lactentes, porem sabe-se que estas interferem negativamente no desempenho das atividades cotidianas e trazem prejuizos ao longo da vida do individuo. Objetivo: Avaliar a relacao entre o processamento sensorial e o desenvolvimento cognitivo de lactentes, e a associacao entre a prematuridade e o processamento sensorial dessa populacao. Metodo: Estudo de corte transversal realizado no Ambulatorio de Puericultura do Hospital das Clinicas da UFPE, no periodo de dezembro de 2009 a agosto de 2010. A amostra consistiu de 182 lactentes de oito a 15 meses de idade, dos quais 54 (29,7%) nasceram prematuros, sendo feita a correcao da prematuridade para 40 semanas de idade gestacional. Utilizou-se o Test of Sensory Functions in Infants (TSFI), para avaliar o processamento sensorial, e a Bayley Scales of Infant and Toddler Development III, na avaliacao do desenvolvimento cognitivo. Resultados: Verificou-se uma frequencia significantemente maior de processamento sensorial em risco e deficiente entre os lactentes nascidos pre-termo (37%) quando comparado ao processo sensorial dos nascidos a termo (21,9%). O atraso cognitivo foi significantemente maior (8,3%) entre os lactentes com processamento sensorial em risco e deficiente em relacao aos com processamento sensorial normal (1,5%). Conclusao: A prematuridade foi considerada um fator de risco para disturbio do processamento sensorial e os lactentes diagnosticados com este disturbio apresentaram atraso cognitivo mais frequentemente. A prematuridade, isoladamente, nao esteve associada ao atraso cognitivo.
MicroRNAs (miRNAs) in Colorectal Cancer

Colorectal cancer (CRC) is the third most common cancer in the world and third leading cause of cancer-related deaths in men and women as well. While early screening procedures and removal of small polyps improve the survival rates among the patients, there is still need for new diagnostic and therapeutic approaches for developing more effective treatments. MicroRNAs (miRNAs) are short noncoding RNA fragments, which involve in posttranscriptional regulation of gene expression, and they are shown to involve in tumorigenesis either targeting oncogenes or tumor suppressor genes. Based on the current studies, miRNAs are now suggested as potential biomarkers for CRC diagnosis, prognosis, and therapeutic responses. In this chapter, the latest findings on the role of miRNA in CRC in many aspects are reviewed: diagnosis (role of circular miRNAs in blood and miRNAs from tissue biopsies and their potential role in pathophysiology and diagnosis of CRC), prognosis (miRNAs related with metastasis, recurrence, and survival rates in CRC), and therapeutic responses (role of miRNAs both in chemotherapies and/or in targeted therapies in CRC). In conclusion, miRNAs are promising molecules for diagnosis, prognosis, and therapeutic responses of CRC. the microprocessor complex) nucleotide (nt) pre-miRNAs. Pre-miRNA, which is by the nuclear export factor exportin-5, is transferred to the cytoplasm. In the cytoplasm, the cytoplasmic RNase Dicer cleaves the pre-miRNA hairpin to its mature length. Dicer in complex with the transactivation response (TAR) RNA-binding protein (also known as TRBP and TARBP2) and argonaute (AGO) 1–4 mediate the processing of pre-miRNA and the assembly of the RISC (RNA-induced silencing complex). With the formation of this complex structure, one strand of the miRNA duplex is removed and single-stranded miRNA is generated. Interaction complex and target induces posttranscriptional silencing destabilization of and suppression between miR-27b, miR-148a, and miR-326 expression levels and progression-free
Using Story Theory to Guide Nursing Practice

Attentively embracing story, a middle range nursing theory, is presented and its use in practice is discussed. The relevance of story path, represented by story-line and markings, is made explicit in the practice application, which describes using the theory with a person who has heart disease. The healing potential embedded in the human story is made explicit through the theory of attentively embracing story. Practicing with the theory is a healing art that promotes the transformational and self-transcendent potential of people.
Medical liability in the electronic medical records era

Abstract Physicians encounter new medical liability risks in a medical milieu subjugated to electronic health information exchange. The budding electronic medical record systems have revolutionized how health care is dispensed. They alter the doctor‐patient relationship in many uncertain and evolving ways. The shifting landscape of electronic information and medical liability risk is important for every practicing physician to understand. We review the historical changes of the electronic medical record, the emerging changes of the maturing electronic medical record, and the medical liability risk for physicians using the emerging electronic medical record systems. Because the electronic medical record appears to be here to stay, it is imperative that physicians adapt to efficient and effective use of the electronic information highway.
Detection of early left ventricular and left atrial dysfunction in type I diabetes mellitus using two dimensional speckle tracking echocardiography

Background Occult left ventricular (LV) systolic and diastolic dysfunction is not uncommon among young adults with type I diabetes mellitus (T1DM). Early detection in the subclinical phase may enhance different preventive strategies. The two-dimensional speckle tracking echocardiography (2D-STE) is a novel and promising tool for the detection of early changes in LV and left atrial (LA) myocardial performance. Aim To detect early LV and LA dysfunction in young adults with T1DM by 2D-STE and its correlation with their functional capacity using the treadmill stress test. Patients and methods Thirty patients with T1DM and 15 nondiabetics acting as controls were enrolled. Conventional 2D echo, tissue Doppler imaging (TDI), and 2D-STE were done. Peak LV global longitudinal strain and peak LA global longitudinal strain were obtained. The functional capacity was assessed using the treadmill stress test. Results A statistically significant decrease in the average peak LV global longitudinal strain was found in diabetics compared to nondiabetics (15.8±6.8 and 23.9±2.7, respectively; P<0.001) and in LV TDI strain rate (19.7±5.4 and 23±2.7, respectively; P<0.05) were found. A statistically significant peak atrial longitudinal strain decrease in the average in diabetics compared to nondiabetics (34.40±12.9 and 42.3±3.9, respectively, P<0.05). There were no significant differences between the two groups with respect to the functional capacity of the parameters. Conclusion Since T1DM is associated with early (subclinical) LV and LA dysfunction, 2D-STE becomes an important and sensitive tool for an early detection of subclinical LV and LA myocardial dysfunction.