Miracle-dz/UniFAR-FTUs huggingface dataset:
PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence

Significance Promyelocytic leukemia protein (PML) nuclear bodies (NBs) are subnuclear domains proposed to facilitate posttranslational modifications. Among NB partners, proteins are p53 and are most of the regulators. Overexpression of a single PML splice variant, PML IV, triggers p53-driven senescence. We demonstrate an interaction between PML IV C terminus and the ARF tumor suppressor. This interaction is required to promote p53 SUMOylation and subsequent stabilization. These results unexpectedly bridge three key tumor suppressors and stress the key role of PML NBs as SUMOylation factories and regulators of senescence. Promyelocytic leukemia protein (PML) nuclear bodies (NBs) recruit multiple partners, including p53 and many of its regulators. NBs are believed to facilitate several posttranslational modifications and are key regulators of senescence. PML, the organizer of NBs, is expressed as a number of splice variants that all efficiently recruit p53 partners. However, overexpression of only one of them, PML IV, triggers p53-driven senescence. Here, we show that PML IV specifically binds ARF, a key p53 regulator. Similar to ARF, PML IV enhances global SUMO-1 conjugation, particularly that of p53, resulting in p53 stabilization and activation. ARF interacts with and stabilizes the NB-associated UBC9 SUMO-conjugating enzyme, possibly explaining PML IV-enhanced SUMOylation. These results unexpectedly link two key tumor suppressors, highlighting their convergence for global control of SUMO conjugation, p53 activation, and senescence induction.
MATERIALES POLIMÉRICOS EN NANOMEDICINA: TRANSPORTE Y LIBERACIÓN CONTROLADA DE FÁRMACOS.

La aparición de nuevas enfermedades, así como la falta de un procedimiento eficaz y menos tóxico para el tratamiento enfermedades como el cáncer, han impulsado el desarrollo de sistemas de transporte y liberación controlada de fármacos. La nanomedicina, un área de gran crecimiento durante las últimas decadas, hace uso de ensambles nanométricos (nanotransportadores) para la liberación controlada de medicamentos. Esta, no solo supera los inconvenientes de los tratamientos clásicos de las enfermedades, si no que también aporta diversas mejoras y nuevas posibilidades. El presente trabajo presenta una revisión de los principales aspectos del diseño de nanotransportadores poliméricos para la liberación controlada de medicamentos.
Hybrid GC-eDRAM/SRAM Bitcell for Robust Low-Power Operation

Conventional static random access memory (SRAM) suffers from high leakage power when implemented in advanced CMOS nodes, while modified bitcells or assist techniques are required to achieve robust low-voltage operation. Gain-cell eDRAM (GC-eDRAM) is an interesting area-efficient alternative to SRAM, but requires refresh cycles and typically a boosted write word-line (WWL). This brief proposes a hybrid GC-eDRAM/SRAM bitcell addressing the leakage power and low voltage robustness issues of SRAM, while avoiding bandwidth-consuming refresh and WWL boost of conventional GC-eDRAM. In the hybrid 8T bitcell, an SRAM keeper latch is connected to the storage node (SN) of a gain cell. The SRAM keepers are power gated most of the time for leakage reduction; the keepers are powered on only during zero bandwidth consuming refresh cycles, after write, and before read, to ensure strong data levels on the SN. Compared to a conventional 6T SRAM bitcell, the hybrid 8T bitcell has a 2T read port and an interruptible keeper for both robust read and write at low voltages. Simulations in 65-nm CMOS show that the hybrid bitcell enables 35% (at 400 mV) to 55% (at 1 V) lower data retention power than an 6T SRAM cell at 25 °C.
La projection d'usage des TICs : la composition de fictions axiomatiques au service de la recherche technologique

L'« hypercompetitivite » (D'Avenir & Gunther, 1994) qui caracterise notre environnement economique contemporain fait de l'innovation une preoccupation strategique pour les organisations. Celles-ci tentent de repondre a cette injonction par le recours a une multitude de « systemes experts », caracteristique de la « modernite avancee » (Giddens, 1990). Parmi ceux-ci, la stimulation des activites de R&D est reconnue comme une contribution majeure qui necessite l'utilisation croissante de champs d'expertises varies. C'est dans ce contexte que les sciences sociales sont mobilisees comme forme d'expertise contributives des « recherches speculatives pour l'innovation » (Stewart & Claeys, 2009). Ces recherches interviennent en amont de processus d'innovation, en un lieu nomme « Fuzzy Front End » (Smith & Reinertsen, 1995), lieu dans lequel se forge la construction de la realite sociale de l'invention : son usage ou plutot sa projection. Notre these s'interroge sur ces technologies de production de connaissances que sont les projections d'usage et ambitionne de rendre intelligibles les politiques qu'elles mettent en oeuvre, la performance des collectifs mobilises sur les recherches et sur eux-memes ainsi que les arrangements deployes par les acteurs durant ces processus. Notre immersion dans le tissu industriel grenoblois, et en particulier dans l'environnement du CEA-LETI, nous a permis de proposer une lecture des projections d'usage comme des compositions de fictions axiomatiques au service de la recherche technologique. En scrutant le concept d'usage, nous mettons en lumiere les carrieres empruntees par celui-ci et les mutations des pratiques associees. En interrogeant l'une des formes de la projection d'usage, le scenario, nous mettons en evidence les liens entre performativite et recours a la fiction. En interrogeant les mutations des composantes du projet, nous demontrons le caractere axiomatique des projections, en tant que forme de reponse a une demande sociale qui emane de plusieurs endroits et dont l'exigence de production de savoirs actionnables necessite de composer avec des donnees en mouvement.
System-Level Effects of Soft Errors in Uncore Components

The effects of soft errors in processor cores have been widely studied. However, little has been published about soft errors in uncore components, such as the memory subsystem and I/O controllers, of a system-on-a-chip (SoC). In this paper, we study how soft errors in uncore components affect system-level behaviors. We have created a new mixed-mode simulation platform that combines simulators at two different levels of abstraction, and achieves <inline-formula> <tex-math notation="LaTeX">$20~000{\times }$ </tex-math></inline-formula> speedup over register-transfer-level-only simulation. Using this platform, we present the first study of the system-level impact of soft errors inside various uncore components of a large-scale, multicore SoC using the industrial-grade, open-source OpenSPARC T2 SoC design. Our results show that soft errors in uncore components can significantly impact system-level reliability. We also demonstrate that uncore soft errors can create major challenges for traditional system-level checkpoint recovery techniques. To overcome such recovery challenges, we present a new replay recovery technique for uncore components belonging to the memory subsystem. For the <italic>L2</italic> cache controller and the dynamic random-access memory controller components of OpenSPARC T2, our new technique reduces the probability that an application run fails to produce correct results due to soft errors by more than <inline-formula> <tex-math notation="LaTeX">$50 {\times }$ </tex-math></inline-formula> with 1.82% and 2.58% chip-level area and power impact, respectively.
CRootBox: A structural-functional modelling framework for root systems

Background and Aims Root architecture development determines the sites in soil where roots provide input of carbon and take up water and solutes. However, root architecture is difficult to determine experimentally when grown in opaque soil. Thus, root architectural models have been widely used and been further developed into functional-structural models that simulate the fate of water and solutes in the soil-root system. We present a root architectural model, CRootBox, as a flexible framework to model architecture and its interactions with static and dynamic soil environments. Methods CRootBox is a C++ -based root architecture model with Python binding, so that CRootBox can be included via a shared library into any Python code. Output formats include VTP, DGF, RSML and CSV. We further created a database of published root architectural parameters. The capabilities of CRootBox for the unconfined growth of single root systems, as well as the different parameter sets, are highlighted into a freely available web application. Key results We demonstrate the use of CRootBox for 5 different cases (1) free growth of individual root systems (2) growth of root systems in containers as a way to mimic experimental setups, (3), field scale simulation, (4) root growth as affected by heterogeneous, static soil conditions, and (5) coupling CRootBox with Soil Physics with Python code to dynamically compute water flow in soil, root water uptake, and water flow inside roots. Conclusions In conclusion, we present a fast and flexible functional-structural root model which is based on state-of-the-art computational science methods. Its aim is to facilitate modelling of root responses to environmental conditions as well as the impact of root on soil. In the future, we plan to extend this approach to the aboveground part of the plant.
Novel Green Luminescent and Phosphorescent Material: Semiconductive Nanoporous ZnMnO with Photon Confinement.

A novel green luminescent and phosphorescent material of semiconductive nanoporous ZnMnO was synthesized by the thermal nucleation of nanopores in the 20-period Zn0.93Mn0. 07O/Zn0.65Mn0. 35O multilayer structure. Nanoporous ZnMnO showed an n-type semiconducting property and exhibited an extremely strong green light emission in its luminescence and phosphorescence characteristics. This arises from the formation of the localized energy level (i.e., green emission band) within the energy band gap and the confinement of photons. The results suggest nanoporous ZnMnO to have a great potential for the new type of semiconducting green phosphors and semiconductor light-emitting diodes with lower thresholds, producing an efficient light emission. In-depth analyses on the structural, electrical, and optical properties are thoroughly examined, and the formation mechanism of nanoporous ZnMnO and the origin of the strong green light emission are discussed.
The carriage of interleukin-1B-31*C allele plus Staphylococcus aureus and Haemophilus influenzae increases the risk of recurrent tonsillitis in a Mexican population

The aim of the present study was to estimate the relative contribution of immunogenetic and microbiological factors in the development of recurrent tonsillitis in a Mexican population. Patients (n = 138) with recurrent tonsillitis and an indication of tonsillectomy (mean age: 6.05 years ± 3.00; median age: 5 years, female: 58; age range: 1–15 years) and 195 non-related controls older than 18 years and a medical history free of recurrent tonsillitis were included. To evaluate the microbial contribution, tonsil swab samples from both groups and extracted tonsil samples from cases were cultured. Biofilm production of isolated bacteria was measured. To assess the immunogenetic component, DNA from peripheral blood was genotyped for the TNFA-308G/A single-nucleotide polymorphism (SNP) and for the IL1B -31C/T SNP. Normal microbiota, but no pathogens or potential pathogens, were identified from all control sample cultures. The most frequent pathogenic species detected in tonsils from cases were Staphylococcus aureus (48.6%, 67/138) and Haemophilus influenzae (31.9%, 44/138), which were found more frequently in patient samples than in samples from healthy volunteers (P < 0.0001). Importantly, 41/54 (75.9%) S. aureus isolates were biofilm producers (18 weak and 23 strong), whereas 17/25 (68%) H. influenzae isolates were biofilm producers (10 weak, and 7 strong biofilm producers). Patients with at least one copy of the IL1B-31*C allele had a higher risk of recurrent tonsillitis (OR = 4.03; 95% CI = 1.27–14.27; P = 0.013). TNFA-308 G/A alleles were not preferentially distributed among the groups. When considering the presence of IL1B-31*C plus S. aureus, IL1B-31*C plus S. aureus biofilm producer, IL1B-31*C plus H. influenzae or IL1B-31*C plus H. influenzae biofilm producer, the OR tended to infinite. Thus, the presence of IL1B-31*C allele plus the presence of S. aureus and/or H. influenzae could be related to the development of tonsillitis in this particular Mexican population.
Contrast‐enhanced 18F‐FDG‐PET/CT for the assessment of necrotic lymph node metastases

Cystic lymph node metastasis (CLNM) is commonly found in human papillomavirus (HPV)‐associated tonsillar squamous cell carcinoma (SCC). The aim of this study was to compare the accuracy in detecting cystic lymph node metastasis from tonsillar SCC between contrast‐enhanced CT, 18F‐ fluorodeoxyglucose‐positron emission tomography (FDG‐PET), non‐enhanced 18F‐FDG‐PET/CT, and contrast‐enhanced 18F‐FDG‐PET/CT.
Research on application of OFDM technology in cooperative spectrum sensing

Cognitive radio (CR) is viewed as a novel approach for improving utilization of the precious radio spectrum. Spectrum sensing is one of the most important technologies in cognitive radio. A general presentation of OFDM technology and cooperative spectrum sensing are given in the first instance. In order to improve detection probability and reduce equipment complex and computation complex, to combine OFDM technology with the cognitive radio, on top of analyzing the application of OFDM technology in cooperative spectrum sensing, the authors advance collaborative sensing method based on energy detection and OFDM. Simulation and analysis results show that the method can effectively improve detecting spectrum holes probability.
A New Method for Locating Solder Joint Based on Rough Set

Continual increases in IC-chip complexity and performance are placing demands on the density and functionality of package I/Os. Therefore, various SMT (surface mounting technology) interconnection techniques are being developed to satisfy this need. Non-destructive inspection technology based on image captured by CCD (charge couple device) has been widely used in a production of PCB (printed circuit board), because of their excellent characters. This paper deals with the locating of solder joints in PCB. In recent years, the theory of rough sets has gained paramount applicability in diverse areas of research, especially in data mining, knowledge discovery, artificial intelligence and information systems analysis. Rough sets have also been used in image processing; however, the application of rough sets for image locating analysis has yet to be fully investigated. In this paper image segmentation using rough set theory has been presented, and then locate the solder joint by calculating the correlation of solder joint image. In traditional production, the locating in automatic optical inspection must be done by manual, so design a new method to find the solder joint region becomes very important. This paper discusses the flow of locating solder joint based on the rough set. Experimental results reveal that the proposed method shows practical value in solder joint inspection.
Analysis of object oriented classification on high resolution images

Classification is one step of image processing which aims to obtain information from remote sensing data. Object oriented classification is a classification algorithm which can be used to process a high resolution image because it uses the object elements as spectral, spatial, and texture. The purpose of this study is to examine the application of object oriented classification on two types of images which are categorized as high resolution images. The study uses two types high resolution image. They are SPOT 5 and QuickBird image covering Ngaglik district, Sleman, Yogyakarta. SPOT 5 was acquired on September 2, 2014 which has 2.5 meters spatial resolution and QuickBird was acquired in 2010 which has 0.6 meters spatial resolution. A field survey was conducted for identifying the classification scheme and testing the classification accuracy. Classification has been done through several stages, involving segmentation, merge parameter determination, rule-based classification, and post classification. Object oriented classification extracts meaningful image objects into several classes based on their spectral, spatial, and texture elements. The utilization of object's spatial element is the advantage of object oriented classification in making classification on the high resolution image. The result of this study shows that object oriented classification algorithm can classify the land use on SPOT 5 image in up to 80.00% accuracy with 16 classes, and QuickBird image in up to 92.00% accuracy with 17 classes. Therefore, object oriented classification is very effective to make classification on the high resolution image. Object oriented classification which uses the high resolution image can produce a good accuracy.
Household Expenditure on Tobacco Consumption in a Poverty-Stricken Rural District in Sri Lanka

Tobacco is a determinant of poverty and a barrier for development. Monaragala, a rural, agricultural district, reports the highest poverty-related indicators in southern Sri Lanka. A cross-sectional study was used to describe the household expenditure on tobacco and its association with food- and education-related expenditures at household level. This study used a 4-stage cluster sampling method to recruit a representative sample of 1160 households. Response rate was 98.6%. Median monthly household income was LKR 20 000 (interquartile range [IQR] = LKR 12 000-30 000). The median monthly expenditure on tobacco was LKR 1000 (IQR = LKR 400-2000) with the highest spending tertile reporting a median of LKR 2700 (IQR = LKR 2000-3600). The proportionate expenditure from the monthly income ranged from 0.0% to 50% with a median of 5.0% (IQR = 2.0-10.0) and a mean of 7.4% (7.6). The poorest reported the highest mean proportionate expenditure (9.8%, SD = 10) from the household income. Household expenditure on tobacco negatively associated with expenditure on education.
Evaluation of a novel sphygmomanometer, which estimates central aortic blood pressure from analysis of brachial artery suprasystolic pressure waves

Background: Central arterial pressure is a better predictor of adverse cardiovascular outcomes than brachial blood pressure, but noninvasive measurement by applanation tonometry is technically demanding. Method: Pulsecor R6.5 is a novel device adapted from a standard sphygmomanometer which estimates the central aortic pressure from analysis of low-frequency suprasystolic waveforms at the occluded brachial artery. A physics-based model, which simulates the arterial system using elastic, thin-walled tube elements and Navier–Stokes equations, is used to calculate arterial pressure and flow propagation. To determine the reliability of the device, we compared 94 central systolic pressures estimated by Pulsecor to the simultaneous directly measured central aortic pressures at the time of coronary angiography in 37 individuals. Results: There was good correlation in central SBP between catheter measurements and Pulsecor estimates by either invasive or noninvasive calibration methods (r = 0.99, P < 0.0001 and r = 0.95, P < 0.0001, respectively). The mean difference in central systolic pressure was 2.78 (SD 3.90) mmHg and coefficient of variation was 0.03 when the invasive calibration method was used. When the noninvasive calibration method was used, the mean difference in central systolic pressure was 0.25 (SD 6.31) mmHg and coefficient of variation was 0.05. Conclusion: We concluded that Pulsecor R6.5 provides a simple and easy method to noninvasively estimate central SBP, which has highly acceptable accuracy.
A residual estimation based approach for isolating faulty parameters

This paper presents a new residual estimation based diagnostic approach that includes detection and fault isolation using the Mahalanobis distance (MD). The faulty performance parameter isolation approach is based on the analysis of residual MD values. The residual value is calculated by taking the difference between MD values estimated in two different scenarios: first, when a performance parameter is present, and second, when that performance parameter is absent. The residual of the MD values for each parameter is obtained by using training data from several experiments as part of the training data analysis planned by the design-of-experiment concept to analyze the impact of each parameter. The distribution of residual MD values for each parameter is analyzed and a 95% probabilistic range is established. This range represents the expected contribution by parameters toward a healthy system's MDs, and it is used to identify the parameters that are responsible for the anomalous behavior of a system. Parameters that fall below the lower bound of the 95% probabilistic range are considered candidates for the anomalous behavior, and the parameter that has the lowest residual value is isolated as the faulty parameter. A case study on computers is presented to demonstrate and test the suggested new approach's ability to isolate faulty parameters.
Effects of Varying Levels of Subatmospheric Pressure on the Rate of Granulation Tissue Formation in Experimental Wounds in Swine

The use of subatmospheric pressure to promote wound healing has increased in popularity during the last several years. The original studies on granulation tissue formation used a 125-mmHg vacuum. The use of alternative sources of subatmospheric pressure has led to many questions regarding efficacy or risk. In this report a swine model is used to quantify and compare the effects of low vacuum suction (25 mmHg) and high vacuum suction (500 mmHg) produced by various vacuum pumps and wall suction systems with the standard 125-mmHg vacuum. Additionally, the effects of an unregulated air leak in the sealing system were examined. All four wound treatments were examined on each of 4 pigs. Wounds were treated until one of the wounds had granulated to a level flush with the surrounding tissue. Wounds treated with the standard 125-mmHg vacuum had filled with granulation tissue by day 8. At this time wounds treated with 25 mmHg had filled 21.2% with new granulation tissue, and wounds treated with 500 mmHg had filled 5.9% with new tissue. Wounds treated with 125 mmHg with a hole in the sealing drape had increased in size 197% because of the debridement of necrotic tissue. In conclusion, wounds treated with a 125-mmHg vacuum exhibited a significant (p < 0.0001) increase in the rate of granulation tissue formation compared with treatment at 25 mmHg or 500 mmHg. The presence of an unregulated air leak in the sealing drape results in significant progression (p < 0.0001) of the wound secondary to dehydration and progressive necrosis.