Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of miRNA-mRNA regulatory modules involved in lipid metabolism and seed development in a woody-oil tree (Camellia oleifera)

BackgroundTea oil camellia ( Camellia oleifera ), an important woody oil tree, is a source of seed oil of high nutritional and medicinal values and has been being widely planted in southern China. However, there is no report on the identification of miRNAs involved in lipid metabolism and seed development in high- and low-oil cultivars of tea oil camellia. Thus, we explored the roles of miRNAs in the critical period of oil formation and accumulation in tea oil camellia, and identified miRNA-mRNA regulatory modules involved in lipid metabolism and seed development. ResultsSixteen small RNA libraries for high- and low-oil cultivars of the critical period of oil biosynthesis were constructed. A total of 196 miRNAs, including 156 known miRNAs from 35 families and 40 novel miRNAs, were identified, and 55 significantly differentially expressed miRNAs were found, which included 34 up-regulated miRNAs and 21 down-regulated miRNAs. An integrated analysis of miRNA and mRNA transcriptome sequence data and qRT-PCR-based information was performed and revealed that nine miRNA-mRNA regulatory modules were related to lipid metabolism, such as the negative regulatory modules of ath-miR858b- MYB82 / MYB3 / MYB44 represses seed oil biosynthesis and a positive regulation module of csi-miR166e-5p- S-ACP - DES6 for formation and accumulation of oleic acid. Twenty-tree miRNA-mRNA regulatory modules were involved in the regulation of seed size, such as a negative regulatory module of hpe-miR162a_L-2- ARF19 involved in early seed development. Twelve miRNA-mRNA regulatory modules regulating growth and development were identified, such as the negative regulatory modules of han-miR156a_L+1- SPL4 / SBP2 promoting early seed development. The targeting relationship of the cpa-miR393_R-1-AFB2 regulatory module were verified by luciferase activity assays. ConclusionMultiple microRNAs (miRNAs) were identified to involve in developing seeds of tea oil camellia, especially discovering several miRNA-mRNA regulatory modules involving in seed development and lipid metabolism. These data provide important theoretical value and a scientific basis for the genetic improvement of new varieties of tea oil camellia in the future.
A low dose of beryllium exposure influences gut microbiota and promotes metabolic syndrome.

Background Elements, including essential minerals and metals, play an important role in human biological functions. Some studies have suggested that exposure to certain elements such as arsenic and cadmium can disturb gut microbiota and result in metabolic disorders. Despite considerable evidence that exposure to toxic heavy metals is significantly associated with host metabolic disorder, few studies have investigated the relationships between fecal elements, gut microbiota, and host metabolism. In order to gain a deeper understanding of the impact of various fecal elements on gut microbiota and metabolic disorder, we have to investigate fecal elements from human stools for association study and demonstrate that certain elements have the causal effect on metabolic disease and changes in gut microbiota. Results We analyzed 28 elements from 304 feces of human twins and evaluated the effects of fecal elements on both gut microbiota and metabolic disorder. Fecal beryllium content was found significantly correlated with biomarkers of metabolic disease and metabolic disease-related gut microbiota such as Akkermansia and Bifidobacterium . In vitro human fecal culture showed marked reduction of species evenness and Bifidobacterium abundance after beryllium treatment. Notably, in mice fed a high-fat diet, 30 ppb of beryllium exposure resulted in significant body weight gain and increased plasma biomarkers for metabolic disorder with an altered microbial community. Beryllium exposure also affected cecal short chain fatty acid profiles, colonic function, and inflammation. Conclusions Our findings indicate that low doses of beryllium, almost similar to the current criteria for beryllium in drinking water, perturb the gut microbiota and worsen metabolic disorders, which is significant implication in public health.
Vivaldi Antipodal Antenna with High Gain and Reduced Side Lobe Level Using Slot Edge with New Neogothic Fractal by Cantor with Application in Medical Images for Tumor Detection

This article addresses the study of the Vivaldi Antipodal Antenna (AVA) seeking to improve the gain, decrease the Side Lobe Level (SLL) and the squint, to make the antenna more directive and obtain a more stable radiation pattern. Its intended application lies in the generation of biological microwave imaging to detect brain tumors. With this objective, the Fractal Slot Edge (FSE) technique was applied with a new fractal developed and based on the Cantor set. The application of this fractal, called Cantor Neogothic Fractal (CNG), formed different-sized cavities resulting, in this work, in three antennas that were analyzed through numerical computational simulation together with AVA. The antennas, called CNG9-FSE-AVA, CNG18-FSE-AVA, and CNG27-FSE-AVA, in which 9, 18, and 27 define the maximum height that the fractal reached in each antenna, have areas equal to 354.66 mm2 , 709.33 mm2 and 1064 mm2 , respectively. All antennas achieved the goal, however, CNG27-FSE-AVA presented the best results at 2 GHz, with a gain of 7.84 dBi, SLL -19.80 dB, and squint of -0.10 degree. Additionally, it was proved that the antenna is suitable to generate a near field microwave imaging of tumors in a brain model.
Uzaktan Eğitimde Uzamsal Görselleştirme: 3 Boyutlu Tasarım Sürecinin Uzamsal Yeteneğe Etkisi

Uzamsal gorsellestirme bireyin bir nesneyi manipule etme becerisi olarak dusunulebilir. Alanyazinda zekanin bir olcusu olarak da tanimlanan uzamsal yetenegin bir cok farkli konu alaninda (matematik, fizik, muhendislik vb.) basari saglamayla da dogrudan iliskisi oldugu gorulmektedir. Bu yetenegin gelistirilebilmesi icin siklikla basvurulan bir yol da 3 boyutlu tasarim etkinlikleridir. 3B calisma ortamlarinda tasarim etkinlikleri yuz yuze yapildigi gibi uzaktan egitim yoluyla es zamanli ya da es zamansiz sekilde de uygulanabilmektedir. Bu calismanin amaci uzaktan es zamanli yurutulen 3B tasarim etkinlikleriyle ilgili surecin durumu incelemek ve bu etkinliklerin lisans ogrencilerinin uzamsal gorsellestirme becerilerine bir etkisinin olup olmadigini belirlemektir. 8 hafta suren calisma, aciklayici durum calismasi deseniyle lisans duzeyinde 21 ogrenci ile ogrenme yonetim sistemi uzerinden es zamanli yapilan 3B tasarim etkinlikleriyle yurutulmustur. PSV (Purdue Uzamsal Gorsellestirme Testi) ve odak grup gorusmeleri veri toplama araclari olarak kullanilmistir. Calisma bulgularina gore ogrencilerin uzamsal gorsellestirme puanlari etkinlik sonrasinda etkinlik oncesine gore anlamli duzeyde farklilik gostermistir. Gorusme verileri, ogrencilerin cevrimici ortamda aldiklari egitimlerde teknik problemler haricinde cok zorlanmadiklarini ve uzamsal dusunme konusunda farkli bir bakis acisi elde ettiklerini gostermektedir. Bulgular, alanyazinla birlikte tartisilarak sonuclandirilmis ve gelecek arastirmalara yonelik cesitli onerilerde bulunulmustur.
AI Based Biped Robot

In this paper, we focus on bipedal robot development and control for different surface conditions using an AI based approach. The core components of our existing robot are pressure sensor, servomotor and software-driven microcontroller. We performed robot system simulation for various ground surface conditions to control the robot with respect to pressure-sensing data that incorporates the two-way interactions between robot and ground. In our machine, we're imposing the robot which may be managed by means of ai. The movement of two-legged gadget is called as taking walks. Strolling can be statically or dynamically solid. Going for walks is usually dynamically solid. Airborne time for ASIMO is 0.08 sec. Keep foot flat at the floor (fully actuated). Estimate hazard of foot roll by means of measuring ground reaction forces. Cautiously design desired trajectories thru optimization. Keep knees bent (avoid singularity). The adaptive trajectory monitoring manages (high remarks profits). The maximum critical undertaking inside the development of biped robot is robotic mechanical structure. Stiffness and compliance consist with biped determine with flexibility of shape. The primary goal is to design a biped shape that may effortlessly control and capable of dealing with entire situation like humans. A normal man can weigh up to ten kg of load without difficulty and panting with accuracy. Even as designing we ought to remember such a lot of parameters inside the proposed machine, we're interfacing the flexi force sensor with Arduino mega. And measuring the foot stress of robotic after that send that fee to raspberry pi primarily based on ai robot will controlled mechanically. When people think of artificial intelligence (ai), the major image that pops up in their heads is that of a robot gliding around and giving mechanical replies.
Experiment-Related Perceived Self-Efficacy Scale: Adaptation to Turkish, Validity and Reliability Studies

Scales related to belief in self-efficacy and in the ability to conduct science (biology, physics, chemistry, science lessons etc.) experiments can be used to investigate the ideas of students on their ability to conduct well-designed experiments, even under difficult conditions. The aim of this research was to adapt “Experiment-Related Perceived Self-Efficacy Scale” that was originally prepared in German to Turkish and to carry out validity and reliability studies. The scale that has been adapted to Turkish by language and field specialists, has also been evaluated in terms of content, language and assessment capacity. The adaptation study was performed on 333 prospective biology and science teachers. The scale that has been adapted to Turkish according to the confirmatory factor analysis results, contains planning, implementation and evaluation sub-dimensions similar to the original scale and consists of 18 items. The Cronbach alpha reliability coefficient of the adapted scale was found to be α=. 92. As a result, the adapted “Experiment-Related Perceived Self-Efficacy Scale” was found to be a valid and reliable assessment instrument in measuring the self-efficacy of conducting experiments.
Validity and Reproducibility of a Semi-quantitative Multiple-choice Food Frequency Questionnaire in Adults Living in Central Iran

Background: To the best of our knowledge, no study has tried to develop and validate a multiple-choice food-based FFQ in Iran using weighed dietary records.This study aimed to investigate the validity and reproducibility of a multiple-choice semi-quantitative food frequency questionnaire (SQ-FFQ)in adults living in central Iran.Methods: Participants attended a large long-term clinical trial were asked to complete three SQ-FFQs by interview, and nine 3-day weighed dietary records (WDRs), over nine months.They provided two blood samples to assess serum calcium, magnesium, zinc, and vitamin C levels.The Pearson and intraclass correlation coefficients (ICC) were calculated to assess reproducibility and validity. The degree of misclassification was explored by using a contingency table of quartiles which is compare the information between third FFQ and WDRs. The method of triads was incorporated to assess validity coefficients between estimated intakes using third FFQ, WDRs, and biochemical markers and assumed true intakes.Results: A total of180 adults aged 48.9±8.4 years completed the study. Compared to WDRs, FFQs overestimated all nutrients intakes except for iron. The median Pearson correlation coefficient was 0.31, 0.44, and 0.38 for FFQ1-FFQ2, FFQ1-FFQ3 and FFQ2-FFQ3, respectively andICC ranged from 0.43 (thiamin) to 0.73 (vitamin D, median: 0.56). The de-attenuated, age, sex, and education adjusted correlation coefficients ranged from 0.01 for vitamin A to 0.40 for vitamin B12 and -0.05 for vitamin A to 0.41 for manganese (median: 0.17 and 0.26) for FFQ1-WDR and FFQ3-WDR, respectively.The medianexact agreement and complete disagreement between FFQ3 and WDRs were 33% and 6%, respectively.The FFQ3validity coefficientsfor vitamin C, calcium, magnesium, and zinc were 0.13, 0.62, 0.89, and 0.66, respectively, using the triads method.Conclusions: The SQ-FFQseems to be an acceptable tool to assess the long-term dietary intake for future large-scale studies in this population.
Rhythms of Dialogue in Infant Research and Child Analysis: Implicit and Explicit Forms of Therapeutic Action

Increasingly psychoanalysis is attempting to integrate the essential “backdrop” of the implicit, nonverbal moment-by-moment process into the narrative domain of language and symbols. We present vignettes from an analytic case of a 3- to 5-year-old child, treated by the first author, to illustrate the integration of the verbal narrative with the implicit moment-by-moment process of vocal rhythms and “action turns. ” We offer a method of explicating the integration of the two levels of meaning. Using second-by-second video microanalysis, we present selected sequences of analytic process, diagramming the details of the verbal narrative and its associated patterns of vocal rhythms and action turns. The article illustrates the vital role of the microprocess in therapeutic action in a child analytic case. Neither the verbal narrative nor the nonverbal process could be fully understood without reference to the other.
An exploration of the experience of caring for children with non-malignant life-limiting conditions including, accessing services and decision-making surrounding the child’s care

Children with non-malignant life-limiting conditions (NMLLCs) constitute the largest proportion of children requiring palliative care. Partly due to technological advances, growing numbers of these children are experiencing improved survival. Care is mostly provided at home by the family, with significant input from a range of health and social care providers at different points in the life trajectory. Little is known about parental experiences of caring for a child with a NMLLC including their experiences of accessing services and decision-making. Similarly, a dearth of information exists regarding the experiences of healthcare professionals caring for this cohort of children. This study aimed to explore the experience of caring for children with NMLLCs including, the experience of accessing services and decision-making. Participants were twenty-three parents (eighteen mothers and five fathers) and twelve healthcare professionals’ recruited from five organisations with a wide geographical remit. A concurrent mixed methods design was adopted. Qualitative data were collected from parents and healthcare professionals through semi-structured interviews. Two standardised measures and a demographic questionnaire collected quantitative data from parents. The measures were the Decisional Conflict Scale (DCS) and the Measure of Processes of Care-20 Scale (MPOC-20). The qualitative data took precedence within this concurrent embedded mixed methods design. Three key themes which emerged from the interviews with the parents were ‘Starting out in haziness’, ‘Managing an unexpected life’ and ‘The ship is going to go down’. Parents reported a generally low level of decisional conflict in the study. In addition, parents reported a generally positive perception of family-centred care provided. Three key themes which emerged from the interviews with the healthcare professionals were ‘Being there’, ‘Being focused’ and ‘Being strong’. Although commonalities across parents’ and professionals’ accounts were noted, key differences were also apparent. Parents and healthcare professionals equally demonstrated an extraordinary level of commitment to the child, focusing on providing expert care. Whilst aspects of good service provision were highlighted, both participant groupings identified that overall current services seemed under-resourced and insufficient to meet child and family needs. However, the perceived need to fight for services and the need to make complex decisions were more apparent in the parents’ accounts. This study is unique as no other study has explored the palliative care needs of children with NMLLCs and their families in an Irish context.
Relationship between Social Capital and Job Performance among Faculty Members of a Medical University: The Moderating Role of Entrepreneurship Behavior

Background Job performance is an important organizational factor that plays a significant role in the success of organizations. This study aims to investigate the moderating role of entrepreneurial behavior in the relationship between social capital and job performance among faculty members of Qazvin University of Medical Sciences. Methods This is a descriptive-analytical study which has been conducted through a structural equation modeling among all university faculty members working in different faculties of Qazvin University of Medical Sciences in 2017. To evaluate the causal relationships between study variables, Structural Equation Modeling (SEM) on AMOS software, with the significant level of 0.05 was used. Results Findings indicated that entrepreneurial behaviors and social capital could predict job performance. The direct effect of social capital on job performance (path coefficient: 0.17) and its indirect effect with the moderating role of entrepreneurial behavior (path coefficient: 0.39) were confirmed (P< 0.05). Furthermore, Sobel test affirmed the indirect associations between variables (P< 0.05). Conclusions Strengthening social capital and promoting entrepreneurial behavior can lead to higher levels of performance. Building trust among organizational members and designing new incentive methods which use entrepreneurial indicators for performance evaluation can improve social capital. Therefore, managers can contribute to the improvement of job performance through developing entrepreneurial behavior among their employees.
“What’s the evidence?”—Towards more empirical evaluations of the impact of OR interventions in healthcare

ABSTRACT Despite an increasing number of papers reporting applications of operational research (OR) to problems in healthcare, there remains little empirical evidence of OR improving healthcare delivery in practice. Without such evidence it is harder both to justify the usefulness of OR to a healthcare audience and to learn and continuously improve our approaches. To progress, we need to build the evidence-base on whether and how OR improves healthcare delivery through careful empirical evaluation. This position paper reviews evaluation standards in healthcare improvement research and dispels some common myths about evaluation. It highlights the current lack of robust evaluation of healthcare OR and makes the case for addressing this. It then proposes possible ways for building better empirical evaluations of OR interventions in healthcare.
Informative Fund Size, Managerial Skill and Investor Rationality

This paper considers the nature of returns to scale in active management following Pastor et al. (2015) who fail to establish diseconomies of scale at the fund level. Using an enhanced empirical strategy, we find a significant negative impact of fund size on performance. This empirical evidence indicates that fund alpha and fund size are not independent entities. Consequently, skill, rather than being measured by the fund alpha, should be measured by the value that a fund extracts from capital markets. We also show that there exist sophisticated investors who correctly exploit positive net present value investment opportunities.
Icosahedral superstrength at the nanoscale

Materials that exhibit extreme hardness, low mass density, and high thermal/chemical stability can often be modeled as simple modifications to the α-rhombohedral phase of boron. To facilitate the development and discovery of these multipurpose, structural ceramics, the current work reveals fundamental physics on the bonding and deformation of p-block hexaborides, an important and representative subclass of icosahedral solids. Icosahedral separation and localization of equatorial bonding are identified as predictors of both elastic moduli and strength. This work also explores nanotwinning, an advanced nanostructure responsible for dramatic records in mechanical performance of both metals and ceramics. To help develop the first model of nanotwinning in ceramics, this work demonstrates (1) that susceptibility to nanotwinning relies on key bonding traits and (2) that nanotwinning minimally affects elasticity and highperiodicity inelasticity. Overall, this work helps rationalize both the mechanical performance of a major class of materials and the cutting-edge mechanism of nanotwinning through fundamental, physics-based approaches.
How Social Media Use at Work Affects Improvement of Older People’s Willingness to Delay Retirement During Transfer From Demographic Bonus to Health Bonus: Causal Relationship Empirical Study

Background With the increased older population in China and the subsequent reduced labor force, the “demographic bonus” is disappearing. The Chinese government proposed a Healthy China strategy in 2017. The transfer of the demographic bonus to a “health bonus” extended the working life of people and reduced the negative impact of the population’s aging on the labor force structure. Objective This research focuses on the effect of older workers’ social media usage at work on their work ability (related to both physical and mental health) and thus their willingness to delay retirement. Methods The questionnaire respondents were older than 55 years, and they obtained the questionnaire from social media, from June to July 2018. A total of 1020 valid questionnaires were collected, and SmartPLS 3.28 (SmartPLS GmbH) was used to analyze the data. Effects were analyzed using 2-tailed t tests. Results (1) Use of social media at work can improve information support (t14=13.318, P<.001), emotional support (t14=13.184, P<.001), and self-efficacy (t14=6.364, P<.001) for older people; (2) information support is the main factor affecting the self-efficacy of older workers (t14=23.304, P<.001), as compared with emotional support (t14=1.799, P=0.07); (3) the impacts of emotional support on work ability (t14=8.876, P<.001) and work stress (t14=9.545, P<.001) are generally higher than those of information support (t14=4.394, P<.001; t14=5.002, P<.001); (4) self-efficacy has an impact on work ability (t14=5.658, P<.001) and work stress (t14=4.717, P<.001); and (5) the impacts of work ability (t14=8.586, P<.001) and work stress (t14=8.579, P<.001) on retirement willingness are greater than those of emotional support (t14=2.112, P=.04) and information support (t14=4.314, P<.001). Conclusions Our study confirms that the use of social media at work has a positive impact on older workers. Based on the findings, we have put forward proposals to extend people’s working lives and help governments implement health bonus policies. In the future, we will compare the different values of willingness to delay retirement among older people in different occupations and different cultures.