Miracle-dz/UniFAR-FTUs huggingface dataset:
Systèmes de gestion de ressources et aspects de disponibilité

tomates. L'avantage de cette approche formelle est double : d'une part,l'utilisateur garde la maitrise de l'impact semantique du tissage et, d'autre part, il peut utiliser de s outils de model- checking pour optimiser le tissage et verifier des proprietes de disponibilite . ABSTRACT. In this paper, we focus on availability properties and the prevention of denia l of services. We propose a domain-specific aspect language to preventthe denials of service caused by resource management. Our aspects specify availability policies by enfor cing time limits in the allocation of resources. In our language, an aspect can be seen a s a formal temporal property on execution traces. Programs and aspects are specified astimed automata and the weaving process as an automata product. The benefit of this formal app roach is two-fold: the user keeps the semantic impact of weaving under control and (s)he ca n use a model-checker to optimize the woven program and verify availability properties.
A Role For Lte1p (a Low Temperature Essential Protein Involved in Mitosis) in Proprotein Processing in the Yeast Secretory Pathway*

We previously identified six single gene disruptions in Saccharomyces cerevisiae that allow enhanced immunoreactive insulin secretion primarily because of defective Kex2p-mediated endoproteolytic processing. Five eis mutants disrupted established VPS (vacuolar protein sorting) genes, The sixth, LTE1, is a Low Temperature (<15 °C) Essential gene encoding a large protein with potential guanine nucleotide exchange (GEF) domains. Lte1p functions as a positive regulator of the mitotic GTPase Tem1p, and overexpression of Tem1p suppresses the low temperature mitotic defect of lte1. By sequence analysis, Tem1p has highest similarity to Vps21p (yeast homolog of mammalian Rab5). Unlike TEM1, LTE1 is not restricted to mitosis but is expressed throughout the cell cycle. Lte1p function in interphase cells is largely unknown. Here we confirm the eis phenotype of lte1 mutant cells and demonstrate a defect in proalpha factor processing that is rescued by expression of full-length Lte1p but not a C-terminally truncated Lte1p lacking its GEF homology domain. Neither overexpression of Tem1p nor 13 other structurally related GTPases can suppress the secretory proprotein processing defect. However, overexpression of Vps21p selectively restores proprotein processing in a manner dependent upon the active GTP-bound form of the GTPase. By contrast, a vps21 mutant produces a synthetic defect with lte1 in proprotein processing, as well as a synthetic growth defect. Together, the data underscore a link between the mitotic regulator, Lte1p, and protein processing and trafficking in the secretory/endosomal system.
Scope Management Strategies for Engineering Leaders to Improve Project Success Rates

Scope Management Strategies for Engineering Leaders to Improve Project Success Rates by Kevin Lee Ramage MBA, Brenau University, 2013 BS, Florida International University, 1998 Doctoral Study Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Business Administration Walden University August 2018 Abstract Civil engineering projects undertaken without successful implementation of scope management strategies by project leaders are approximately 10% more likely to fail than projects undertaken with scope management strategies. Using scope management theory, the purpose of this single case study was to explore scope management strategies used by some project leaders in the engineering field to improve project success rates. Data wereCivil engineering projects undertaken without successful implementation of scope management strategies by project leaders are approximately 10% more likely to fail than projects undertaken with scope management strategies. Using scope management theory, the purpose of this single case study was to explore scope management strategies used by some project leaders in the engineering field to improve project success rates. Data were collected using semistructured interviews with 3 purposefully selected project leaders in Georgia, and a review of project completion reports, budget reports, government proposals, and scope management documents. Data analysis occurred using Yin’s 5-step process of compiling, disassembling, reassembling, interpreting, and concluding the data. The 3 emergent themes were client management strategy, schedule adherence strategy, and communication strategy. The findings indicated that implementing the scope management strategies of client management, schedule adherence, and communication with all stakeholders are essential for improving engineering project success rates. The implications for social change include the potential to elevate the use of sustainabledesign application through water, energy, and natural resource conservation by project leaders through scope management strategy implementation. People in communities potentially benefit from the findings of this study because of the increased use of sustainable materials, reduced use of water, energy, and natural resources, and an improved local environment. Scope Management Strategies for Engineering Leaders to Improve Project Success Rates by Kevin Lee Ramage MBA, Brenau University, 2013 BS, Florida International University, 1998 Doctoral Study Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Business Administration Walden University August 2018 Dedication I dedicate this study to my parents and my son without whose support and motivation, this effort would not have been possible. Acknowledgments I would like to thank all of the faculty members at Walden University without whose help and patience, this study would not have been possible.
Research on Influences of Individual Social Network on Startups of Returned Migrant Workers

Researches show, social network has been a great help and promotion for the business establishment and operation. Based on returned rural migrant workers at X city, Sichuan Province, this article makes a questionnaire survey on 112 startup owners who are returned rural migrant workers, and Factor Analysis Method is used to research the roles of individual social network in the business startup and operation. The research results show, 6 factors among individual social networks including families relatives, clients, suppliers, banks, opponents and local authorities have played an important role in the business startup, of which, clients and suppliers have obvious effect in promoting the business operation. During the business establishment and operation, startup owners should make full use of three social resources including external workers, industrial institutions and local authorities. Keywords—social network; returned rural migrant workers; business startup; Sichuan province
Abordagens para a pesquisa por palavra-chave em bases de dados estruturadas

Os sistemas de pesquisa na web tornaram popular a pesquisapor palavras-chave. Este metodo de pesquisa melhorou claramente a usabilidadedas pesquisas na web. Por outro lado, as tradicionais pesquisasestruturadas que conhecemos da area das bases de dados estruturadasenvolvem um formulario com varias caixas de texto que testam determinadosatributos na base de dados. Deste modo, tem havido um esforcocrescente nos ultimos anos, tanto a nivel academico como a nivelempresarial, para a criacao de aplicacoes que permitam a pesquisa porpalavras-chave sobre bases de dados estruturadas. Por um lado, surgiramextensoes nos sistemas de gestao de base de dados relacionais paradar resposta a esta necessidade, e por outro, apareceram varios sistemasopen-source baseados em modelos nao relacionais. Este trabalho comparaas capacidades reais das plataformas existentes que seguem ambosos modelos para resolver eficientemente a pesquisa por palavras-chaveem informacao estruturada.
Reduced virulence of Serpulina hyodysenteriae hemolysin-negative mutants in pigs and their potential to protect pigs against challenge with a virulent strain

The role of the Serpulina hyodysenteriae hemolysin encoded by the tlyA gene in the pathogenesis of swine dysentery (SD) was studied. tlyA mutants of two S. hyodysenteriae strains (B204 and C5) were tested for virulence in pigs. None of the animals developed SD. However, after infection with wild-type strain B204 or C5, the incidence of SD was 100 or 60%, respectively. Thus, the tlyA-encoded hemolysin of S. hyodysenteriae is an important virulence factor in SD. The potential of these mutants to protect pigs against challenge with a virulent S. hyodysenteriae strain was also studied. After challenge with wild-type strain B204, 50% of pigs previously inoculated with the B204 tlyA mutant were protected, whereas all control pigs contracted SD. None of the pigs previously inoculated with the C5 tlyA mutant developed SD upon challenge with wild-type strain B204, whereas 40% of the control pigs developed SD in this experiment. Thus, previous colonization with S. hyodysenteriae tlyA mutants in pigs provides partial protection against challenge with a virulent S. hyodysenteriae strain.
Calcium and magnesium contents of mammalian erythrocyte membranes.

Calcium and magnesium contents of whole erythrocytes and of erythrocyte membranes (stroma) were determined by atomic absorption technique on five mammalian species, man, rabbit, pig, cow and dog.In every species, the magnesium content of the whole erythrocyte is predominantly higher than the calcium content. Of the total magnesium, about 2-6% are localized in the membrane, whereas 40-86% of the whole cell calcium are found in the membrane. Except that the magnesium content of bovine erythrocyte is remarkably lower (about 1/7) than those of the other species, there seems to be no big species difference in these cation contents in the whole erythrocytes.The amounts of calcium localized in the membrane were found to be in a range of 1.5-2.6×10-18 mole per cell. The membrane magnesium contents vary considerably among the species examined and fall in a range of 1.6 (cow)-12 (dog)×10-18 mole per cell, with the intermediate values on the other three species of 4.0, 4.1 and 5.6×10-18 mole per cell. The membrane Mg/Ca molar ratios range between 0.65-6.5. Intracellular concentrations of calcium and magnesium were calculated from the differences between the amounts in the whole cell and those in the membrane, assuming that no release of these cations occurs in the course of preparation of stroma.
Sensorless control of PMSM for base speed range using Two-Degree-of-Freedom MTPA current control and HF test current injection for low speed range

In this paper a recently published innovative sensorless Two-Degree-of-Freedom current control scheme for the whole speed range is extended for a maximum torque per ampere (MTPA) control. Saturation is taken into account for the calculation of the MTPA trajectory by use of current dependent machine parameters which were identified beforehand. For low and zero speed operation test current injection is used to gain a position error signal. Sensorless control performance is deteriorated by cross-saturation and higher harmonic saliencies which are considered by current and position dependent inductances. A flatness based test signal pre-control provides compensation for those secondary saliencies. For mid and high speed operation the model based dynamic feed forward control is modified in order to achieve a high quality position error signal from the tracking controller. Like this no additional model based estimator evaluating back-EMF information is needed. The proper functioning of the proposed method is proven by experimental results.
Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways

We evaluated the ability of different trypsin-revealed tethered ligand (TL) sequences of rat proteinase-activated receptor 2 (rPAR2) and the corresponding soluble TL-derived agonist peptides to trigger agonist-biased signaling. To do so, we mutated the proteolytically revealed TL sequence of rPAR2 and examined the impact on stimulating intracellular calcium transients and mitogen-activated protein (MAP) kinase. The TL receptor mutants, rPAR2-Leu37Ser38, rPAR2-Ala37–38, and rPAR2-Ala39–42 were compared with the trypsin-revealed wild-type rPAR2 TL sequence, S37LIGRL42—. Upon trypsin activation, all constructs stimulated MAP kinase signaling, but only the wt-rPAR2 and rPAR2-Ala39–42 triggered calcium signaling. Furthermore, the TL-derived synthetic peptide SLAAAA-NH2 failed to cause PAR2-mediated calcium signaling but did activate MAP kinase, whereas SLIGRL-NH2 triggered both calcium and MAP kinase signaling by all receptors. The peptides AAIGRL-NH2 and LSIGRL-NH2 triggered neither calcium nor MAP kinase signals. Neither rPAR2-Ala37–38 nor rPAR2-Leu37Ser38 constructs recruited β-arrestins-1 or -2 in response to trypsin stimulation, whereas both β-arrestins were recruited to these mutants by SLIGRL-NH2. The lack of trypsin-triggered β-arrestin interactions correlated with impaired trypsin-activated TL-mutant receptor internalization. Trypsin-stimulated MAP kinase activation by the TL-mutated receptors was not blocked by inhibitors of Gαi (pertussis toxin), Gαq [N-cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide (GP2A)], Src kinase [4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]-pyrimidine (PP1)], or the epidermal growth factor (EGF) receptor [4-(3′-chloroanilino)-6,7-dimethoxy-quinazoline (AG1478)], but was inhibited by the Rho-kinase inhibitor (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl (Y27362). The data indicate that the proteolytically revealed TL sequence(s) and the mode of its presentation to the receptor (tethered versus soluble) can confer biased signaling by PAR2, its arrestin recruitment, and its internalization. Thus, PAR2 can signal to multiple pathways that are differentially triggered by distinct proteinase-revealed TLs or by synthetic signal-selective activating peptides.
The share of ultra-processed foods determines the overall nutritional quality of diets in Brazil

Abstract Objective To estimate the dietary share of ultra-processed foods and to determine its association with the overall nutritional quality of diets in Brazil. Design Cross-sectional. Setting Brazil. Subjects A representative sample of 32 898 Brazilians aged ≥10 years was studied. Food intake data were collected. We calculated the average dietary content of individual nutrients and compared them across quintiles of energy share of ultra-processed foods. Then we identified nutrient-based dietary patterns, and evaluated the association between quintiles of dietary share of ultra-processed foods and the patterns’ scores. Results The mean per capita daily dietary energy intake was 7933 kJ (1896 kcal), with 58·1 % from unprocessed or minimally processed foods, 10·9 % from processed culinary ingredients, 10·6 % from processed foods and 20·4 % from ultra-processed foods. Consumption of ultra-processed foods was directly associated with high consumption of free sugars and total, saturated and trans fats, and with low consumption of protein, dietary fibre, and most of the assessed vitamins and minerals. Four nutrient-based dietary patterns were identified. ‘Healthy pattern 1’ carried more protein and micronutrients, and less free sugars. ‘Healthy pattern 2’ carried more vitamins. ‘Healthy pattern 3’ carried more dietary fibre and minerals and less free sugars. ‘Unhealthy pattern’ carried more total, saturated and trans fats, and less dietary fibre. The dietary share of ultra-processed foods was inversely associated with ‘healthy pattern 1’ (−0·16; 95 % CI −0·17, −0·15) and ‘healthy pattern 3’ (−0·18; 95 % CI −0·19, −0·17), and directly associated with ‘unhealthy pattern’ (0·17; 95 % CI 0·15, 0·18). Conclusions Dietary share of ultra-processed foods determines the overall nutritional quality of diets in Brazil.
Establishing the limits of normal cerebral ageing and senile dementias

Cognitive deterioration is so commonly observed in the elderly that it is considered by many to be an inevitable feature of the ageing process. Some researchers have proposed that the senile dementias are the inevitable end-point of this process, should the person live long enough. The differentiation of normal cerebral ageing from disease process is important in the selection of control groups for research, and also for clinical decision-making. In the latter context it is important to ask at what level of dysfunction intervention should occur, and whether this should be active or palliative. Cognitive change in the elderly is here considered from biological, neuropsychological and epidemiological viewpoints. Current research suggests that senile dementia is the result of the interplay of genetically determined disease processes, ageing-related decline which may be regulated at a cellular level, and neuronal repair and compensation mechanisms. Therefore, to debate whether dementia is simply an extension of a normal ageing process or not is probably too simplistic an approach.
An Overview Use of Analytic Hierarchy Process (AHP) in Design for Remanufacturing Activities

This paper gives an overview usage of Analytic Hier archy Process (AHP) as a decision support model for selecting a set of Design for Remanufacturing (DfRe m) criteria and assigns importance weightings into t to make a decision. Increasingly remanufacturing an d recovers activities are gaining popularities amon g remanufacturers due to its potential value and sust ainability get serious attention among the develope d and developing countries as one of business arm for the nation. Although traditionally, the remanufacturing sectors was explored by small and i ndependent manufacturers, but nowadays increases the number of original equipment manufacturers such as Xerox, Caterpillar, Kodak, Delphi as named it few are highly and actively involved on this field. Although, the remanufacturing sectors are expendi ng, there is limited of literatures and theories on dec ision making for DfRem had been covered by academicians, industry players or researchers on th is field. There is need for a decision making in pr oduct design as well as process design that address reman ufacturing issues at early phase of product development. AHP can be incorporated into a compreh ensive information system for supporting Design for Remanufacturing (DfRem) activities. An initial framework on decision making using AHP for DfRem is proposed based on literature findings and case s tudie inputs obtained from the local remanufacture rs.
In situ localization of heat‐shock and histone proteins in honey‐bee (apis mellifera l.) larvae infected with paenibacillus larvae

The immunohistochemical localization of the heat shock proteins (Hsp70 and Hsp90) and histone protein in healthy and Paenibacillus larvae infected honeybee (Apis mellifera L.) larvae has been studied. Hsp70 was found in the nuclei and the cytoplasm of infected midgut, salivary gland cells and haemocytes, but not in uninfected larvae. Hsp90 was localized in both infected and uninfected cells. Exposed histone proteins were localized in the nuclei of dying uninfected cells undergoing programmed cell death. The distribution of histone protein in uninfected cells of midgut, salivary gland, and other tissues was nuclear and indicative of normal programmed cell death at levels between 1 and 5%.
Explanatory study of factors affecting purchase intention of low-technology innovation of local products in Surabaya

The purpose of this study is to examine the effect of consumer doubt, skepticism, familiarity, value for money, information seeking, and aesthetic design on purchase intention of low-technology innovation of the local product. There are 7 variables used for this research, namely consumer doubt, skepticism, familiarity, value for money, information seeking, aesthetic design, and purchase intention. This research applied a quantitative approach with multiple linear regression method. Data gathered from 200 respondents who bought low-technology innovation products of local products in Surabaya. The data processing used PASW Statistic 18 for Windows software. The results of this study indicate that consumer doubt, skepticism, familiarity, value for money, information seeking, and aesthetic design simultaneously have a significant effect on purchase intention of low-technology innovation of local products. However, if the variables are tested separately, it is found that consumer doubt and skepticism have a significant negative effect on purchase intention. Familiarity, information seeking, and aesthetic design have a significant positive influence on purchase intention. While of value for money has an insignificant effect on purchase intention.
The Association of False‐Positive Rapid Plasma Reagin Results and HIV Infection

Background and Objectives: To study the relationship between a false positive rapid plasma reagin (RPR) result (FP), syphilis, and HIV infection in our patients. Methods: A prospective study of the incidence of FP tests and syphilis in the general population and its relationship to HIV infection over a period of 6 months. Results: 8.76% of the population were HIV positive. False positives were found in 15% and 1.2% of the HIV infected and noninfected patients, respectively; the attributable risk for HIV was 14.97. Syphilis was found in 5% and 0.9% of the positive and negative HIV patients, respectively; the attributable risk for HIV was 5.4. Conclusions: The incidence of false positive RPR results in the HIV‐infected population is significantly higher than that of the non‐HIV‐infected patients.
The R2R3-MYB–Like Regulatory Factor EOBI, Acting Downstream of EOBII, Regulates Scent Production by Activating ODO1 and Structural Scent-Related Genes in Petunia[C][W]

Using a protoplast-based promoter-activation system, this work identifies a MYB-like factor termed EOBI that is important in floral scent production. Direct interactions of EOBI with EOBII and of both proteins with ODO1 and structural phenylpropanoid scent-related genes allow tight regulation of scent throughout flower development. Flower scent is a highly dynamic trait, under developmental, spatial, and diurnal regulation. The mechanism governing scent production is only beginning to be unraveled. In petunia (Petunia hybrida), EMISSION OF BENZENOIDS II (EOBII) controls transcription of both the shikimate pathway-regulating MYB factor ODORANT1 (ODO1) and phenylpropanoid scent-related structural genes. A promoter-activation screen identified an R2R3-MYB–like regulatory factor of phenylpropanoid volatile biosynthesis acting downstream of EOBII, designated EOBI. EOBI silencing led to downregulation of ODO1 and numerous structural scent-related genes from both the shikimate and phenylpropanoid pathways. The ability of EOBI to directly activate ODO1, as revealed by electrophoretic mobility shift assay and yeast one-hybrid analysis, place EOBI upstream of ODO1 in regulating substrate availability for volatile biosynthesis. Interestingly, ODO1-silenced transgenic petunia flowers accumulated higher EOBI transcript levels than controls, suggesting a complex feedback loop between these regulatory factors. The accumulation pattern of EOBI transcript relative to EOBII and ODO1, and the effect of up/downregulation of EOBII on transcript levels of EOBI and ODO1, further support these factors' hierarchical relationships. The dependence of scent production on EOBI expression and its direct interaction with both regulatory and structural genes provide evidence for EOBI’s wide-ranging involvement in the production of floral volatiles.