Miracle-dz/UniFAR-FTUs huggingface dataset:
Inositol 1,4,5‐Trisphosphate 3‐Kinase mRNA: High Levels in the Rat Hippocampal CA1 Pyramidal and Dentate Gyrus Granule Cells and in Cerebellar Purkinje Cells

Abstract: The distribution of inositol 1,4,5‐trisphosphate (InsP3) 3‐kinase mRNA in the rat brain is reported using oligonucleotides based on a cDNA clone sequence that encodes rat brain InsP3 3‐kinase and the in situ hybridization technique. Moderate levels were found in CA2‐4 pyramidal neurons, in the cortex, and in the striatum. The cerebellar granule cells, thalamus, hypothalamus, brainstem, spinal cord, and white matter tracts were almost negative. The levels of InsP3 3‐kinase mRNA were highest in the hippocampal CA1 pyramidal neurons, granule cells of the dentate gyrus, and cerebellar Purkinje cells. These results contrast with the lower concentration of the InsP3 receptor already reported in the hippocampus versus the Purkinje cells and suggest a special role for inositol 1,3,4,5‐tetrakisphosphate in Ammon's horn.
Harnessing Performance for Flexibility in Instrumenting a Virtual Machine for JavaScript through Metacircularity

The limited reflexion features of the JavaScript (JS) language [5] on object operations and function calls has forced researchers, on tasks requiring run-time instrumentation, either to laboriously instrument production VMs or come up with ad hoc source-to-source translation schemes for each problem at hand. This paper shows that, by systematizing the second approach, it is possible to provide a dynamic run-time instrumentation of the object operations and function calls by running a metacircular VM on top of a performanceoriented JIT VM, without having to modify its source code. Our implementation, Photon, achieves a performance 2x slower than a state-of-the-art interpreter and 50x slower than a state-of-the art JIT implementation. The combination of simplicity of usage and efficiency of our system renders obsolete the necessity of instrumenting production VMs for instrumentation tasks that require interpreter-level performance and solves the core technical issues behind many source-to-source translation schemes.
Effective Modulation of Ni Silicide Schottky Barrier Height Using Chlorine Ion Implantation and Segregation

Using a presilicide implantation approach, we demonstrate that the Schottky barrier height (SBH) of NiSi/n-Si(100) can be modulated by doping a Si substrate with a halogen species such as chlorine. Activation energy measurements indicate that an ultralow barrier of 0.08 eV for NiS/n-Si can be achieved when a high dose (~1 times 1015 cm2) of chlorine is implanted prior to Ni silicidation. A secondary ion mass spectroscopy analysis on the presilicide Cl-implanted NiSi shows chlorine segregates at the interface with SBH tuning from 0.68 to 0.08 eV on n-Si and a corresponding increase in hole SBH on p-Si(100). The presilicide Cl-implanted NiSi film also demonstrates an enhanced thermal stability with a low sheet resistively of < 28 muOmega even up to 850degC.
Validation of grading scales for contact lens complications

The validity of use of two artist‐rendered and two photographic sets of grading scales (grading ‘systems’) designed for gauging the severity of contact lens‐related ocular pathology was assessed in terms of precision and reliability. Thirteen observers each graded 30 images — by interpolation or extrapolation to the nearest 0.1 increment — of each of the three contact lens complications (corneal staining, conjunctival redness and papillary conjunctivitis) that were common to all four grading systems. This entire procedure was repeated approximately two weeks later, yielding a total data base comprising of 9360 individual grading estimates. Analysis of variance revealed statistically significant differences in both precision and reliability between systems, observers and conditions (p<0.03 for system reliability; p=0.0001 for all other combinations). The artist‐rendered systems generally afforded lower grading estimates and better grading reliability than the photographic systems. Corneal staining could be graded less reliably than conjunctival redness and papillary conjunctivitis. Grading reliability was generally unaffected by the severity of the condition being assessed. Notwithstanding the above differences, all four grading systems are validated for clinical use and practitioners can initially expect to use these systems with average 95% confidence limits of ±1.2 grading scale units (observer range ±0.7 to ±2.5 grading scale units). In view of the significant between‐system differences revealed in this study, it is advisable to consistently use the same grading system. It may be possible to reduce between‐observer differences by applying personalised correction factors to normalise grading estimates.
The returns to cognitive abilities and personality traits in Germany DIW

We provide the first joint evidence on the relationship between individuals’ cognitive abilities, their personality and earnings for Germany. Using data from the German SocioEconomic Panel Study, we employ scores from an ultra-short IQ-test and a set of measures of personality traits, namely locus of control, reciprocity and all basic items from the Five Factor Personality Inventory. Our estimates suggest a positive effect of so-called fluid intelligence or speed of cognition on males’ wages only. Findings for personality traits are more heterogeneous. There however is a robust wage penalty for an external locus of control for both men and women.
A Wideband Dual-Polarized Slot Antenna

In this letter, we have proposed a dual-polarized planar circular slot antenna for wideband application. Two orthogonal polarizations were achieved by adopting different feeding mechanisms with high ports isolation. The horizontal polarization is excited by a meander-line coupled slot, and the vertical polarization is fed by a stepped monopole. The prototype of the proposed antenna has been built and tested. The proposed design obtained a fairly wide bandwidth (1.70-2.71 GHz) and a high isolation (> 33 dB) over the entire band. The gain of the dual polarizations is also measured and discussed.
Effects of Cyclosporin A on Cell Fusion in a Monkey Kidney Cell Line Persistently Infected with Measles Virus

The authors studied the effects of immunosuppressive peptide cyclosporin A (CsA) on cell fusion efficiency in cells persistently infected with measles virus (448-PI-Vero cells). Treatment of 448-PI-Vero cells with 5 µM CsA enhanced the infusion. In addition, the expression of measles virus antigen on cell surface was increased by treatment with CsA. The addition of phenothiazine, an anti-calmodulin drug, enhanced the fusion of 448-PI-Vero cells in the presence of CsA, although treatment with phenothiazine alone did not affect polykaryocyte formation. The enhancement of fusion efficiency in 448-PI-Vero cells by CsA was suppressed by oligopeptide Z-D-Phe-Phe-Gly, a synthetic oligopeptide that inhibits fusion induced by measles virus. Since the cell content of major virus-specific polypeptides, such as hemagglutinin, nucleoprotein or matrix protein is the same as in untreated controls, this fusion enhancement may be related to transport and accumulation of measles virus glycoproteins.
A 2-Transistor Sub-1 V Low Power Temperature Compensated CMOS Voltage Reference : Design and Application

This paper presents the design and application of a CMOS sub-1V voltage reference using a 2-transistor Self-Cascode MOSFET (SCM) structure able to get low power consumption, temperature compensation, and small area. An efficient design procedure applied to this simple topology relying on NMOS transistors with different threshold voltages allows attaining large immunity against bias current and supply voltage variations. The two transistors can operate in weak, moderate, or strong inversion making the design flexible in terms of area and power consumption. Implemented in a > 0.18mm standard CMOS technology, the circuit provides a 400mV voltage reference with a variation of ±0.18% from -20°C to 75°C (or less than 15ppm/°C), operates from 3.6V down to 800mV while biased with a 5nA resistor-less PTAT current source that varies ±30% over PVT, and consumes less than 20nA with an area of 0.01mm2. The same concept was used to create a temperature compensated voltage drop with regard to a monitored power supply voltage but using a 2-PMOS SCM structure with transistors of different threshold voltages. These two circuits were adopted as part of a Power Management (PM) system for RFID tag applications. The PM includes a LDO voltage regulator and a low voltage detector that require both the voltage reference and the low voltage monitor. The LDO regulated output voltage and the trip-point of the voltage detector vary +/-5.5% and +/-3.3%, respectively, over temperature, without trimming.
Comparison of the Host Immune Response to Herpes Simplex Virus 1 (HSV-1) and HSV-2 at Two Different Mucosal Sites

ABSTRACT A study was undertaken to compare the host immune responses to herpes simplex virus 1 (HSV-1) and HSV-2 infection by the ocular or genital route in mice. Titers of HSV-2 from tissue samples were elevated regardless of the route of infection. The elevation in titers of HSV-2, including cell infiltration and cytokine/chemokine levels in the central nervous system relative to those found following HSV-1 infection, was correlative with inflammation. These results underscore a dichotomy between the host immune responses to closely related alphaherpesviruses.
Enhanced Radiation From a Horizontal Dipole Closely Placed Above a PEC Ground Plane Using a Parasitic Strip

A straight parasitic strip, closely and horizontally placed above a perfect electrical conductor ground plane, is used to greatly enhance the radiation of a horizontally positioned center-fed half-wave dipole through the phase compensation from the strip. The method is discussed and validated by both full-wave electromagnetic simulation and experiments. Using the parasitic strip, a horizontal dipole with a height of 1/20 wavelength above the ground exhibits an input resistance of 62 Ω and gain of 7.8 dBi while the dipole without the strip and a dipole with a height of a quarter wavelength above the ground realize the resistance of 5/72 Ω and the gain of 4.3/7.8 dBi across a |S11| ≤ -10-dB bandwidth of 0.6%, respectively.
Revised questionnaire on the sense of humor.

Abstract. — A Sense-of-Humor Questionnaire (SHQ), based on the proposed 3–dimensional theory of sense of humor, was given to male and female students in social and physical sciences to test its construct validity. There were positive and significant correlations between the laughter-activating dimension (Mp) and each of the two laughter-inhibiting dimensions (Lp, and Ep), the latter being zero correlated with each other. In a two-way analysis of variance (sex X science), the main effects were a sex difference on the Lp- as well as Ep-dimension, while no main effect was found on the Mp-dimension. The Lp-scores discriminated between men and women in the social sciences, and the Ep-scores in the physical sciences. All results are in agreement with theory.
Nonmitogenic morphoregulatory action of pp60v-src on multicellular epithelial structures

Madin-Darby canine kidney (MDCK) cells form polarized, multicellular epithelial structures in vitro. Low-level expression of pp60v-src in MDCK cells elicits plasticity in these multicellular structures. Plasticity was revealed by the displacement of cells from mechanically stressed regions of the epithelial monolayers; however, the two-dimensional relationship between the cells in the remainder of the monolayer was maintained. Electron microscopy of multicellular structures revealed abnormal separation of the lateral membranes of adjacent cells and selective uncoupling of the junctional complex; the zonula adherens was disrupted, but the zonula occludens and desmosomes were retained. Significantly, this result was not accompanied by transformation of the cells, as judged by the absence of anchorage-independent growth potential. These results demonstrate a nonmitogenic biological activity of pp60v-src which is experimentally dissociable from transformation. This morphoregulatory action on higher-order epithelial structures may reflect a function of related cellular tyrosine kinases.
Characterization of Membrane Association Domains within the Tomato Ringspot Nepovirus X2 Protein, an Endoplasmic Reticulum-Targeted Polytopic MembraneProtein

ABSTRACT Replication of nepoviruses (family Comoviridae) occurs in association with endoplasmic reticulum (ER)-derived membranes. We have previously shown that the putative nucleoside triphosphate-binding protein (NTB) of Tomato ringspot nepovirus is an integral membrane protein with two ER-targeting sequences and have suggested that it anchors the viral replication complex (VRC) to the membranes. A second highly hydrophobic protein domain (X2) is located immediately upstream of the NTB domain in the RNA1-encoded polyprotein. X2 shares conserved sequence motifs with the comovirus 32-kDa protein, an ER-targeted protein implicated in VRC assembly. In this study, we examined the ability of X2 to associate with intracellular membranes. The X2 protein was fused to the green fluorescent protein and expressed in Nicotiana benthamiana by agroinfiltration. Confocal microscopy and membrane flotation experiments suggested that X2 is targeted to ER membranes. Mutagenesis studies revealed that X2 contains multiple ER-targeting domains, including two C-terminal transmembrane helices and a less-well-defined domain further upstream. To investigate the topology of the protein in the membrane, in vitro glycosylation assays were conducted using X2 derivatives that contained N-glycosylation sites introduced at the N or C termini of the protein. The results led us to propose a topological model for X2 in which the protein traverses the membrane three times, with the N terminus oriented in the lumen and the C terminus exposed to the cytoplasmic face. Taken together, our results indicate that X2 is an ER-targeted polytopic membrane protein and raises the possibility that it acts as a second membrane anchor for the VRC.
Drug-Eluting Stents Compared with Bare Metal Stents Improve Late Outcome after Saphenous Vein Graft but Not after Large Native Vessel Interventions

Objectives: To define long-term efficacy of different stent types in saphenous vein graft (SVG) interventions. Methods: In BASKET (Basel Stent Cost Effectiveness Trial), major adverse cardiac events (MACE), i.e. cardiac death, myocardial infarction and symptom-driven target vessel revascularization (TVR) were assessed after 18 months comparing drug-eluting stents (DES) versus bare metal stents (BMS), and SVG and large native vessels (≧3.0 mm). Results: Large vessel interventions were performed in 605 patients. Patients with SVG interventions (n = 47, 8%) were older and had more often hypertension, prior myocardial infarction, prior revascularization and multivessel disease and less frequent ST-elevation myocardial infarction than patients with large native vessel interventions (n = 558, 92%). Stent number and length were higher in SVG than in large native vessel interventions. Baseline characteristics were similar for DES and BMS. In SVG stenting, long-term outcome was better in DES- than in BMS-treated patients (MACE 21 vs. 62%, p = 0.007, mainly due to TVR 18 vs. 46%, p = 0.045), but for large native vessel stenting, no significant difference was noted (MACE: 13 vs. 16%, p = 0.40). Conclusions: Among patients with SVG disease, treatment with DES resulted in a better long-term outcome than treatment with BMS. In contrast, no DES benefit was found in similarly sized native vessels regarding MACE.
A Cognitive Psychological Approach to Identify the Significance of the Role of Visual Sense in Haptic Sense

The purpose of this study is to elucidate the role of visual sense in haptic sense. Humans recognize the outside world 83.0% by visual sense. From these facts, it should be cleared the significance of visual sense in recognizing the object, and how human combine the stimuli from visual sense and haptic sense to recognize objects. Accordingly, human are able to recognize objects correctly even if they have only the stimuli from either visual sense or haptic sense. Many haptic researches have not utilized complex approaches in recognizing objects. The two cognitive psychological evaluations were conducted in order to compare and assess these two approaches. Both experiments were participated by the same 30 volunteers (age: 21.4±1.6.) An experiment that included haptic sense with objects and an experiment of just visual sense without haptic sense were conducted separately on two days. The binary-test method of fitting goodness was associated with the Wilcox on signed-rank test. The results showed that humans were able to recognize the objects' so-called touch sensation of objects' by visual sense and/or haptic sense. In the absence of haptic memory, human is not able to recognize the objects' haptic sensations of objects' by visual sense. In that case, haptic sense is more essential than all other senses. Also, this study proved that visual sense evoked haptic memory, although its role in recognizing haptic sense was partial.
Pulmonary edema produced by intratracheal injection of milk, feeding mixtures, and sugars.

DURING the course of a study of experimental milk-aspiration pneumonia produced in rabbits by intratracheal injection of human milk, cow's milk, and feeding mixtures, 1 it was found that injection of 10 to 20 cc. of the feeding mixtures often caused fatal pulmonary edema within a few minutes. Injections of similar amounts of human or cow's milk rarely produced this effect. Evaluation of the contents of the feeding mixture suggested that the difference in the effects of the injection of the feeding mixture as compared to injection of unfortified human milk or cow's milk was due to the larger amount of carbohydrate in the feeding mixture. This led to a more detailed study of the production of acute pulmonary edema by intratracheal injection of feeding mixtures, human milk, cow's milk, and solutions of the carbohydrates present in milk and the common feeding mixtures. METHODS Intratracheal injections of feeding mixture (2
Mesenchymal stem cells seeded on cross-linked and noncross-linked acellular porcine dermal scaffolds for long-term full-thickness hernia repair in a small animal model.

Biological meshes are biomaterials consisting of extracellular matrix that are used in surgery particularly for hernia treatment, thoracic wall reconstruction, or silicone implant-based breast reconstruction. We hypothesized that combination of extracellular matrices with autologous mesenchymal stem cells used for hernia repair would result in increased vascularization and increased strength of incorporation. We cultured autologous adipose-derived stem cells harvested from the inguinal region of Wistar rats on cross-linked and noncross-linked porcine extracellular matrices. In 24 Wistar rats, a standardized 2×4 cm fascial defect was created and repaired with either cross-linked or noncross-linked grafts enriched with stem cells. Non-MSC-enriched grafts were used as controls. The rats were sacrificed at 3 months of age. The specimens were examined for the strength of incorporation, vascularization, cell invasion, foreign body reaction, and capsule formation. Both materials showed cellular ingrowth and neovascularization. Comparison of both tested groups with the controls showed no significant differences in the capsule thickness, foreign body reaction, cellularization, or vascularization. The strength of incorporation of the stem cell-enriched cross-linked extracellular matrix specimens was higher than in acellular specimens, but this result was statistically nonsignificant. In the noncross-linked extracellular matrix, the strength of incorporation was significantly higher in the stem cell group than in the acellular group. Seeding of biological meshes with stem cells does not significantly contribute to their increased vascularization. In cross-linked materials, it does not ensure increased strength of incorporation, in contrast to noncross-linked materials. Owing to the fact that isolation and seeding of stem cells is a very complex procedure, we do not see sufficient benefits for its use in the clinical setting.
Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014

The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) is increasing worldwide. Here we present associated patient data and molecular, epidemiological and phenotypic characteristics of all CPE isolates in Norway from 2007 to 2014 confirmed at the Norwegian National Advisory Unit on Detection of Antimicrobial Resistance. All confirmed CPE isolates were characterized pheno- and genotypically, including by whole genome sequencing (WGS). Patient data were reviewed retrospectively. In total 59 CPE isolates were identified from 53 patients. Urine was the dominant clinical sample source (37%) and only 15% of the isolates were obtained from faecal screening. The majority of cases (62%) were directly associated with travel or hospitalization abroad, but both intra-hospital transmission and one inter-hospital outbreak were observed. The number of CPE cases/year was low (2–14 cases/year), but an increasing trend was observed. Klebsiella spp. (n = 38) and E. coli (n = 14) were the dominant species and blaKPC (n = 20), blaNDM (n = 19), blaOXA-48-like (n = 12) and blaVIM (n = 7) were the dominant carbapenemase gene families. The CPE isolates were genetically diverse except for K. pneumoniae where clonal group 258 associated with blaKPC dominated. All isolates were multidrug-resistant and a significant proportion (21%) were resistant to colistin. Interestingly, all blaOXA-48-like, and a large proportion of blaNDM-positive Klebsiella spp. (89%) and E. coli (83%) isolates were susceptible in vitro to mecillinam. Thus, mecillinam could have a role in the treatment of uncomplicated urinary tract infections caused by OXA-48- or NDM-producing E. coli or K. pneumoniae. In conclusion, the impact of CPE in Norway is still limited and mainly associated with travel abroad, reflected in the diversity of clones and carbapenemase genes.
[Validity and reliability of mammographic interpretation by Mexican radiologists, using the BI-RADS system].

OBJECTIVE Mammographic interpretation using the BI-RADS system determines if a patient will continue in the regular screening program or needs additional studies for breast cancer diagnosis, hence the importance of its evaluation. Sensitivity, specificity, diagnostic accuracy of mammographic interpretation and inter- and intra-observer variation, were assessed in a random sample of 29 radiologists from the Mexican Ministry of Health. MATERIAL AND METHODS Eighty diagnostic and screening mammographic studies were selected from the National Cancer Institute in Mexico City. Under the same conditions, two interpretations using the BI-RADS system were performed by each of the participating radiologists. RESULTS Sensitivity in the first and second measurement was 72 and 74% respectively, while the specificity was 80% for the first and 82% for second. Multivariate analysis showed a positive association between the last year number of interpreted mammograms, the number of courses taken and diagnostic accuracy (beta=0.00002, 95% CI 0.000004, 0.00003, p=0.02, beta=0.005, CI 95% -0.0004, 0.01, p=0.07, respectively). Inter-observer agreement was low in both measurements (kappa=0.24, kappa=0.25, respectively). However, after combining BI-RADS categories in 2, agreement increased to 0.46 for both measurements. The intra-observer agreement was good (kappa=0.67). CONCLUSIONS The number of mammographic studies interpreted the previous year is a good measure of the experience of the radiologist and is reflected in the diagnostic accuracy of mammographic interpretation. Courses on mammographic interpretation also have a positive impact on performance.