Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of magnesium in the protection of entomopathogenic nematodes from soil pollution with oil derivatives.

The aim of the paper was to identify the influence of magnesium on the preservation of pathogenic abilities of entomopathogenic nematodes living in soil contaminated with oil derivatives. Entomopathogenic nematodes living under natural conditions in soil or applied to soil as biopreparations for plant pest control are sensitive to soil contamination with heavy metals and oil derivatives. These nematodes do not respond directly by higher mortality but by a decrease in their pathogenic abilities, which adversely affects the success in searching and eliminating pests. A Polish commercial preparation called Owinema SC, containing infective juveniles of Steinernema feltiae Filipjev (Rhabditida: Steinernematidae), was used to test the effect of oil derivatives on pathogenicity and reproduction of entomopathogenic nematodes. Soil was polluted with petrol, diesel oil and used engine oil; the control was soil unpolluted with oil derivatives. Magnesium sulphate was also added (MgSO4∙H2O) in the amount of 160 mg per 1 liter of the suspension. The three oil derivatives in concentrations of: 0.3, 0.6 and 1.0 g or in double doses, i.e. 0.6, 1.2 and 2.0 g were poured over weighted soil batches. The control remained intact. Three replications of each treatment were made. Subsequently, Tenebrio molitor L. larvae used as bait inesct were placed in containers with the suspension. The bait insects were kept in the containers for 7 days, and afterwards they were removed from the soil and taken from the traps in order to check their mortality rate. Furthermore, to test the reproduction ability of entomopathogenic nematodes, dead larvae were moved to “islands” previously prepared according to the Dutky method. The results were presented as the number of entomopathogenic nematodes per 1 dead larvae of Tenebrio molitor L.
Exploring Indicators of Digital Self-Harm with Eating Disorder Patients

Digital self-harm encompasses a variety of activities, including the use of social media to facilitate or amplify mental illness-related behaviors. To understand the extent of these behaviors and their impacts, we conducted an in-depth case study with three patients who are in recovery from an eating disorder. We collected survey data, conducted interviews reflecting back to their technology use during their active disease state, and reviewed up to 18 months of their social media data leading up to the start of their initial point of recovery. Through the triangulation of this data, we explore the role of social media and social technologies in relation to their eating disorder. By utilizing this methodology, we were able to provide a contextually rich and nuanced lens for exploring the impacts of digital self-harm on this group of patients. We found that patients acknowledged that the eating disordered content on social media had a negative impact on their health, often contributing to a worsening of the physical manifestations of their disorder. Conversely, while they actively consumed this content, our participants did not produce online content related to eating disordered activities or behaviors. Finally, we discuss the patterns within their social media data and how platform designers and operators could use these findings in the future through design considerations for future platform-based interventions.
Novel Approach to Cluster Synchronization in Kuramoto Oscillators

Cluster synchronization is investigated in different complex dynamical networks. Based on an extended Kuramoto model, a novel approach is proposed to make a complex dynamical network achieve cluster synchronization, where the critical coupling strength between connected may be obtained by global adaptive approach and local adaptive approach, respectively. The former approach only need know each node’s state and its destination state; while the latter approach need know the local information. Simulation results show the effectiveness of the distributed control strategy.
Socioeconomic Factors and the Consumption of Wine in Tenerife

In this paper we measure the impact of an individual's socioeconomic conditions on the decision to consume wine in a traditionally wine-producing area. Based on the data obtained in an exhaustive survey on wine consumption and through discrete choice models, we assess the changes which come about in the decisions to consume the different types of wine under consideration, and we obtain the most relevant distinctive and differentiated characteristics for each one of them.
Attitudes of Saudi SME Executives Towards the Selection and use of Strategic Planning Tools and Techniques

The SME sector in Saudi Arabia is an important one in terms of GDP contribution and employment generation, but strategic planning in SME's does not tend to be conducted as commonly as in larger firms. It is especially important for gaining competitive advantages and for their long-term survival. A sample of 211 Saudi SME owners and senior managers were surveyed in an investigation into their use of strategic planning tools and techniques and their attitudes towards the selection and planning. The results identify Human Resource analysis, SWOT analysis, TQM, Mission/Vision statement, CRM, Porter's Five Forces, and financial analysis as the most commonly used ones in order. Comparisons are drawn with other similar studies, and the results include breakdown and change analyses. The extent of satisfaction for each tool/technique was also ascertained, and the extent of agreement on a range of views on strategic planning revealed an overall positive and encouraging attitude.
Ignored pattern in studies of local adaptations: When the grass is greener on the allopatric site

Recently, the focus within microevolutionary studies has been on the ecological divergence of populations. One subset of this research field includes studies on local adaptation. This approach is useful for studying whether or not adaptive spatial variation takes place in a metapopulation context. There is growing body of research studying local adaptations of populations, and much of this has used a formal test for assessing the existence of local adaptation. According to Kawecki and Ebert (2004), the “Local vs. foreign” criterion is fulfilled if the local population has higher fitness than other populations in its own locality and “Home vs. away” is fulfilled if a population has higher fitness in the sympatric than allopatric environment. Interestingly, interpretation of results not fulfilling these criteria has received scant attention even though the question of how to measure local adaptation is vital for the study field. At present, there is an extensive volume of published results showing other kinds of patterns than those proposed by the “Local vs . foreign” or “Home vs . away” criteria. Here, we highlight one of these alternative patterns that we believe may have an adaptive background and may show local adaptation not recognized by the above-mentioned criteria.
Factors from Underwriter That Influence Initial Return of the Companies Doing Initial Public Offerings in Indonesia Stock Exchange in the Period of 2004-2011

The objective of this study is to examine whether the underwriter's factors affect the initial return of the companies that were going to do Initial Public Offerings (IPO). This study uses the quantitative approach using Ordinary Least Squares (OLS) method to examine whether the underwriter's factors affect the initial return. The samples of this study are companies which are doing the IPO in Indonesia Stock Exchange in the period of 2004- 2011. This study finds that the underwriter's factors have significant effect for the companies which do IPO, such as prestige, number of syndicate, experience, and oversubscription. But other independent variables like reputation, total assets, age, and price revision have no significant impact to initial return. The paper provides useful information for issuers how to choose good underwriters to avoid underpricing which causes wealth transfer to investors, the underwriters with good prestige, big syndicates, a lot of experiences, and less of doing oversubscription are recommended.
FORMULATION AND EVALUATION OF CHLORHEXIDINE GLUCONATE DENTAL GELS

Chlorhexidine used to reduce oral bacteria and dental plaque also it has bactericidal and bacteriostatic properties. The gel was formulated by using different polymers with different concentration. Ten different formulae were prepared and characterized physically in term of color, syneresis, spread ability, pH, drug content and rheological properties. F2 composition formulation were found to be good and can be used for the preparation of Chlorhexidine gluconate dental gels.
Microsatellite analysis reveals connectivity among geographically distant transmission zones of Plasmodium vivax in the Peruvian Amazon: A critical barrier to regional malaria elimination

Despite efforts made over decades by the Peruvian government to eliminate malaria, Plasmodium vivax remains a challenge for public health decision-makers in the country. The uneven distribution of its incidence, plus its complex pattern of dispersion, has made ineffective control measures based on global information that lack the necessary detail to understand transmission fully. In this sense, population genetic tools can complement current surveillance. This study describes the genetic diversity and population structure from September 2012 to March 2015 in three geographically distant settlements, Cahuide (CAH), Lupuna (LUP) and Santa Emilia (STE), located in the Peruvian Amazon. A total 777 P. vivax mono-infections, out of 3264, were genotyped. Among study areas, LUP showed 19.7% of polyclonal infections, and its genetic diversity (Hexp) was 0.544. Temporal analysis showed a significant increment of polyclonal infections and Hexp, and the introduction and persistence of a new parasite population since March 2013. In STE, 40.1% of infections were polyclonal, with Hexp = 0.596. The presence of four genetic clusters without signals of clonal expansion and infections with lower parasite densities compared against the other two areas were also found. At least four parasite populations were present in CAH in 2012, where, after June 2014, malaria cases decreased from 213 to 61, concomitant with a decrease in polyclonal infections (from 0.286 to 0.18), and expectedly variable Hexp. Strong signals of gene flow were present in the study areas and wide geographic distribution of highly diverse parasite populations were found. This study suggests that movement of malaria parasites by human reservoirs connects geographically distant malaria transmission areas in the Peruvian Amazon. The maintenance of high levels of parasite genetic diversity through human mobility is a critical barrier to malaria elimination in this region.
Overexpression of the Long Non-Coding RNA NeSt and FOXCUT in Early Stages of Prostate Cancer Samples as Promising Biomarkers.

BACKGROUND Prostate cancer is one of the most common cancers in males worldwide. Recently, it is well characterized that long non-coding RNAs (lncRNA) play critical roles in the initiation, development, and progression of prostate cancer. NeST, an intergenic lncRNA, was found to be a positive regulator of the pro-inflammatory cytokine, IFN-ɣ, which is responsible for both antitumor immunity properties as well as tumor evasion. FOXCUT, an-other lncRNA, is mainly a regulator of transcription factor, FOXC1 that is believed to be involved in tumor development and progression. METHODS In a case-control study, 66 paraffin-embedded prostate tissues representing 36 pathologically confirmed cancer and 30 control samples were examined. The cancer samples were classified in a total of three stages based on PSA levels, tumor volume, and Gleason score. RNA extraction was performed for quantitative determination of IFN-ɣ, lncRNA NeSt, and lncRNA FOXCUT gene expression in both case and control prostate tissues. RESULTS Our results showed that NeST lncRNA was significantly up-regulated in prostate cancer samples compared to control, while NeST lncRNA and IFN-ɣ gene expression was detected mainly in early stages of prostate cancer. The patients with higher NeST and FOXCUT expression had poor clinical features including PSA levels and tumor volume comparing those with lower expression. Moreover, there was a strong correlation between lncRNA FOXCUT and IFN-ɣ expression. CONCLUSIONS Our data suggests that lncRNA NeST and lncRNA FOXCUT may be able to be introduced as novel molecules involved in prostate cancer development and may provide a potential prognostic biomarker and therapeutic target.
Clinical Utility of Human Papillomavirus Genotyping in Cervical Cancer Screening: A Systematic Review

Supplemental digital content is available in the text. Objective Thirteen human papillomavirus (HPV) genotypes are associated with the highest risk of cervical disease/cancer; however, the risk of disease progression and cancer is genotype dependent. The objective of this systematic review was to examine evidence for high-grade cervical intraepithelial neoplasia (≥CIN 3) risk discrimination using HPV genotyping. Materials and Methods A systematic review of English and non-English articles through MEDLINE, Cochrane, clinicaltrials.gov, and abstracts presented at relevant professional society conferences were searched from 2000 to 2019. Search terms included: cervical cancer screening, HPV genotyping, CIN, HPV persistence, humans, and colposcopy; prospective, controlled trials, observational studies, and retrospective studies of residual specimens; evidence included HPV genotyping (beyond genotypes 16/18/45) results. Data were obtained independently by authors using predefined fields. Risk of bias was evaluated with a modified Newcastle-Ottawa Scale. The Grading of Recommendations, Assessment, Development and Evaluation methodology facilitated overall quality of evidence evaluation for risk estimation. The study protocol was registered with the PROSPERO International Prospective Register of Systematic Reviews (CRD42018091093). The primary outcome was CIN 3 or worse risk both at baseline and at different follow-up periods. Results Of 236 identified sources, 60 full texts were retrieved and 16 articles/sources were included. Risk of bias was deemed low; the overall quality of evidence for CIN 3 or worse risk with negative for intraepithelial lesions or malignancies or low-grade squamous intraepithelial cytology was assessed as moderate; that with atypical squamous cells-undetermined significance and “all cytology” was assessed as high. Clinical and methodological heterogeneity precluded meta-analysis. Human papillomavirus genotyping discriminated risk of CIN 3 or worse to a clinically significant degree, regardless of cytology result. Conclusions The evidence supports a clinical utility for HPV genotyping in risk discrimination during cervical cancer screening.
A negative feedback regulatory loop between miR-138 and TP53 is mediated by USP10

TP53 is a critical tumor suppressor. In approximately 50% of human cancers the TP53 gene is either lost or mutated. The expression level of TP53 in the cells is tightly controlled by a fine-tune machinery, mainly through the Mdm2-mediated ubiquitination pathway. On the other side, the ubiquitinated TP53 could be reversed and stabilized by USP7 and USP10, to keep the amount of TP53 in check. MicroRNAs can negatively regulate TP53 expression levels through direct targeting or positively regulate TP53 function through the repression of negative regulators of TP53. Here we report that microRNA-138 controls TP53 expression by directly targeting USP10. Furthermore, TP53 represses microRNA-138 expression, forming a negative feedback regulatory loop. This finding adds another layer of complexity to the TP53 network.
Factors Underlying Farmers’ Decisions to Participate in Networks

The objective of this elicitation study is to provide insights into farmers’ beliefs which influence their participation in knowledge exchange and innovation networks to enable the enhancement of network participation. A set of facilitating and impeding factors was obtained. Participants identified (a) 13 categories of behavioural beliefs (e.g. ‘You learn something’ and ‘Low perceived return on investment’), (b) 4 groups of normative beliefs (influence of colleagues, spouses, network coordinators and chain partners) and (c) 11 control beliefs (facilitators or barriers related to, for example, ‘Network skills’, ‘No time’ and ‘Perceived restraint by farmers in communicating openly and honestly’).
What's Gender Got to Do with It? Incivility in the Federal Courts

The current study examines experiences of interpersonal mistreatment in federal litigation among a random sample of 4,608 practicing attorneys. Using both quantitative and qualitative survey data, we documented the nature and interplay of general incivility, gender-related incivility, and unwanted sexual attention. Nearly 75% of female attorneys had experienced some form of this misconduct in the previous five years, compared to half of male attorneys. An in-depth examination of instigators revealed that not only fellow attorneys but also federal judges, court personnel, marshals, and court security officers instigated the inappropriate behavior. We further found that most attorneys responded to this mistreatment with avoidance and denial; few used or trusted existing reporting mechanisms. The current study surpassed simple prevalence estimates to document effects of interpersonal mistreatment on the professional well-being of targeted attorneys. We discuss implications of these results, drawing on theories of social dominance, sex-role spillover, cognitive stress, organizations, and intervention.
Inference of Historical Population-Size Changes with Allele-Frequency Data

With up to millions of nearly neutral polymorphisms now being routinely sampled in population-genomic surveys, it is possible to estimate the site-frequency spectrum of such sites with high precision. Each frequency class reflects a mixture of potentially unique demographic histories, which can be revealed using theory for the probability distributions of the starting and ending points of branch segments over all possible coalescence trees. Such distributions are completely independent of past population history, which only influences the segment lengths, providing the basis for estimating average population sizes separating tree-wide coalescence events. The history of population-size change experienced by a sample of polymorphisms can then be dissected in a model-flexible fashion, and extension of this theory allows estimation of the mean and full distribution of long-term effective population sizes and ages of alleles of specific frequencies. Here, we outline the basic theory underlying the conceptual approach, develop and test an efficient statistical procedure for parameter estimation, and apply this to multiple population-genomic datasets for the microcrustacean Daphnia pulex.
Thalidomide and Lenalidomide for Refractory Systemic/Cutaneous Lupus Erythematosus Treatment

Background Thalidomide has shown exceptional results in systemic/cutaneous lupus erythematosus(SLE/CLE). Recently, lenalidomide has been also prescribed for SLE/CLE treatment. Literature regarding efficacy/adverse events for these drugs is scarce with a single systematic review and meta-analysis focused solely on thalidomide for refractory cutaneous lupus subtypes. Objective We, therefore, addressed in this narrative review the efficacy/adverse effects of thalidomide and lenalidomide for SLE and CLE. In addition, we provide a specialist approach for clinical practice based on the available evidence. Results Efficacy of thalidomide for refractory cutaneous lupus treatment was demonstrated by several studies, mostly retrospective with small sample size(≤20). The frequency of peripheral polyneuropathy is controversial varying from 15-80% with no consistent data regarding cumulative dose and length of use. Drug withdrawn results in clinical partial/complete reversibility for most cases (70%). For lenalidomide, seven studies (small sample sizes) reported its efficacy for SLE/CLE with complete/partial response in all patients with a mean time to response of 3 months. Flare rate varied from 25-75% occurring 0.5-10 months after drug withdrawn. There were no reports of polyneuropathy/worsening of previous thalidomide-induced neuropathy, but most of them did not perform nerve conduction studies. Teratogenicity risk exist for both drugs and strict precautions are required. Conclusions Thalidomide is very efficacious as an induction therapy for patients with severe/refractory cutaneous lupus with high risk of scarring, but its longstanding use should be avoided due to neurotoxicity. Lenalidomide is a promising drug for skin lupus treatment, particularly regarding the apparent lower frequency of nerve side effects.
Weed infestations of winter wheat depend on the forecrop and the tillage system

In-crop weed infestation is affected by both habitat conditions and agronomic practices, including the forecrop and tillage treatments used. This study evaluated the effect of the forecrop and the tillage system on species composition, number and dry weight of weeds in a winter wheat ‘Astoria’. A field study was carried out over the period 2014–2017 at the Uhrusk Experimental Farm (SE Poland), on a mixed rendzina soil with a grain-size distribution of sandy loam. Wheat was grown in a four-course crop rotation: soybean – winter wheat – rapeseed – winter wheat. The experimental factors were as follows: a forecrop of winter wheat (soybean and winter rapeseed) and a tillage system (ploughing and no-tillage). Avena fatua was the most frequently occurring weed in the wheat crop sown after soybean, whereas after winter rapeseed it was Viola arvensis. Viola arvensis was the dominant weed under both tillage systems. In all experimental treatments, the species Viola arvensis and Cirsium arvense were characterized by the highest constancy (Constancy Class V and IV), and also Veronica arvensis after the previous winter rapeseed crop. In the wheat crop sown after winter rapeseed, the number of weeds was found to be higher by 62.1% and the weed dry weight higher by 27.3% compared to these parameters after the previous soybean crop. A richer floristic composition of weeds was also observed in the stand after winter rapeseed. Under conventional tillage conditions, compared to no-tillage, the number of weeds was found to be lower by 39.7% and their dry weight by 50.0%. An increase in the numbers of the dominant weed species was also noted in the untilled plots.