Miracle-dz/UniFAR-FTUs huggingface dataset:
Behavioral and social outcomes in adolescent survivors of childhood cancer: a report from the childhood cancer survivor study.

PURPOSE Adolescents, regardless of medical history, may face behavioral and social challenges. Cancer and related treatments represent additional challenges for teens navigating the transition from childhood to adulthood. This study was conducted to evaluate behavioral and social outcomes of adolescent childhood cancer survivors using data from the Childhood Cancer Survivor Study. PATIENTS AND METHODS We evaluated 2,979 survivors and 649 siblings of cancer survivors to determine the incidence of difficulty in six behavioral and social domains (depression/anxiety, headstrong, attention deficit, peer conflict/social withdrawal, antisocial behaviors, and social competence). Outcomes were determined by calculating parent-reported scores to questions from the behavior problem index. RESULTS Survivors and siblings were similar in age at the time of interview (mean: 14.8, survivors; 14.9, siblings; range, 12 to 17 years). Overall, multivariate analyses showed that survivors were 1.5 times (99% CI, 1.1 to 2.1) more likely than siblings to have symptoms of depression/anxiety and 1.7 times (99% CI, 1.3 to 2.2) more likely to have antisocial behaviors. Scores in the depression/anxiety, attention deficit, and antisocial domains were significantly elevated in adolescents treated for leukemia or CNS tumors when compared with siblings. In addition, survivors of neuroblastoma had difficulty in the depression/anxiety and antisocial domains. Treatments with cranial radiation and/or intrathecal methotrexate were specific risk factors. CONCLUSION Adolescent survivors of childhood cancer, especially those with a history of leukemia, CNS tumors, or neuroblastoma, may be at increased risk for adverse behavioral and social outcomes. Increased surveillance of this population, in combination with development of interventional strategies, should be a priority.
The role of nitric oxide synthases and nitrotyrosine in retinoblastoma

To investigate the potential involvement of the nitric oxide (NO) pathway in retinoblastoma, the authors correlated immunoreactivity for endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and nitrotyrosine (NT) with the degree of tumor invasiveness in retinoblastoma.
Clinoenstatite: High-Low Inversion

Clinoenstatite undergoes a metastable displacive inversion at 995�C. The new phase can be indexed (from x-ray powder pattern) on a triclinic cell with dimensions a = 10.00 �; b = 8.934 �; c = 5.170 �; alpha = 88.27�; beta = 70.03�; gamma = 91.09�. The new phase persists from 995� to 1010�C at the composition MgSiO3. For a solid solution (15 percent by weight) of diopside in clinoenstatite, the new phase persists from 995� to at least 1400�C and does not invert in periods of several hours to protoenstatite, the phase previously thought to be the stable form in this region.
A Systematic Review of the Effect of Therapists' Internalized Models of Relationships on the Quality of the Therapeutic Relationship.

OBJECTIVE Previous reviews have found equivocal evidence of an association between therapists' internalized relational models and the therapeutic relationship and have neglected empirical literature based on Sullivan's notion of introject. This review expanded upon previous reviews to examine the effect of therapist internalized relational models on a broader conceptualization of the therapeutic relationship. METHOD Systematic search processes identified 22 papers measuring therapist attachment and/or introject and therapeutic relationship: 19 on therapist attachment, 5 on introject with 2 overlapping. RESULTS Overall, despite heterogeneity in design and variable methodological quality, evidence suggests that therapist attachment affects therapeutic relationship quality, observed in client-rated evaluation, therapist negative countertransference, empathy, and problems in therapy. Interaction effects between client and therapist attachment style were also found. Evidence suggesting that therapist introject also affects therapeutic relationship quality, including therapists' manner and feelings toward their clients, was stronger. CONCLUSION Evidence clearly shows that therapists' internalized relational models affect the therapeutic relationship. More research is necessary to clarify exactly how therapist and client internalized relational models interact and translate these findings into clinical practice.
Photoperiodic Induction in Quail as a Function of the Period of the Light-Dark Cycle: Implications for Models of Time Measurement

The earliest detectable event in the photoperiodic response of quail is a rise in luteinizing hormone (LH) secretion beginning at about hour 20 on the first long day. The timing of this rise was measured in castrated quail after entrainment to short daylengths which cause significant phase angle differences in the circadian system: (1) LD 2:22 and LD 10:14, and (2) LD 3:21 (T = 24 hr) and LD 3:24 (T = 27 hr). The quail were then exposed to 24 hr of light (by delaying lights-off ), and the time of the first LH rise was measured; it was similar in all schedules. Quail were also entrained to LD 3:21 or LD 3:24 and then given a single 6-hr nightbreak 6-12, 7-13, or 13-19 hr after dawn. The earlier pulse was marginally more inductive in the 27-hr cycle. Thus the entrainment characteristics of the photoinducible rhythm (Φ1) in quail appear very different from those of the locomotor circadian rhythm, and raise doubts as to whether Φ1 is a primary circadian oscillator.
Relationship between subsinus bone height and bone volume requirements for dental implants: a human radiographic study.

PURPOSE To analyze the vertical dimension of subsinus alveolar bone that is available for placement of endosseous implants. MATERIALS AND METHODS Subsinus alveolar bone height (SBH) was determined via radiographs and categorized into three groups: Group A corresponded to SBH < 5 mm; group B SBH of 5 to 9 mm; and group C, SBH > 9 mm. Statistical analysis was carried out using the Wilcoxon paired test with the threshold for statistical significance set at P < . 05. RESULTS Five hundred eighty-three panoramic radiographs of edentulous maxillae were analyzed. In 96.9% of radiographs, the anterior border of the maxillary sinus was above the first premolar. Mean SBH values for canine, first premolar, second premolar, first molar, and second molar sites were 11.4 ± 6.2 mm, 10.6 ± 3.8 mm, 5.9 ± 2.5 mm, 3.3 ± 2.2 mm, and 4.5 ± 2.4 mm, respectively. Representations of groups A, B, and C in the canine region were 14.3%, 21.4%, and 64.3%, respectively; in the first premolar region they were 8.3%, 22.3%, and 69.4%, respectively; in the second premolar region, these were 31.6%, 60.9%, and 7.5%, respectively; in first molar region, the values were 73.1%, 25.4%, and 1.5%, respectively; and in the second molar region they were 54.2%, 41.7%, and 4.1%, respectively. CONCLUSIONS The mean SBH is the highest in the area of the anterior border of the sinus; it declines significantly toward the posterior maxilla, reaches its minimum in the area of the first molar, and increases again significantly in the second molar region. From a clinical point of view, the lateral window technique of sinus elevation remains the dominant augmentative procedure in the molar area, whereas in the premolar area, less invasive alternative methods may be more appropriate.
Non-adiabatic pumping in classical and quantum chaotic scatterers

We study directed transport in periodically forced scattering systems in the regime of fast and strong driving where the dynamics is mixed to chaotic and adiabatic approximations do not apply. The model employed is a square potential well undergoing lateral oscillations, alternatively as two- or single-parameter driving. Mechanisms of directed transport are analyzed in terms of asymmetric irregular scattering processes. Quantizing the system in the framework of Floquet scattering theory, we calculate directed currents on the basis of transmission and reflection probabilities obtained by numerical wavepacket scattering. We observe classical as well as quantum transport beyond linear response, manifest in particular in a non-zero current for single-parameter driving where according to adiabatic theory, it should vanish identically.
On the Correlation Between GNSS-R Reflectivity and L-Band Microwave Radiometry

This work compares microwave radiometry and global navigation satellite systems-reflectometry (GNSS-R) observations using data gathered from airborne flights conducted for three different soil moisture conditions. Two different regions are analyzed, a crops region and a grassland region. For the crops region, the correlation with the I/2 (first Stokes parameter divided by two) was between 0.74 and 0.8 for large incidence angle reflectivity data (30°-50°), while it was between 0.51 and 0.61 for the grassland region and the same incidence angle conditions. For the crops region, the correlation with the I/2 was between 0.64 and 0.69 for lower incidence angle reflectivity data (<;30°), while it was between 0.41 and 0.6 for the grassland region. This indicates that for large incidence angles the coherent scattering mechanism is dominant, while the lower incidence angles are more affected by incoherent scattering. Also a relationship between the reflectivity and the polarization index (PI) is observed. The PI has been used to remove surface roughness effects, but due to its dependence on the incidence angle only the large incidence angle observations were useful. The difference in ground resolution between microwave radiometry and GNSS-R and their strong correlation suggests that they might be combined to improve the spatial resolution of microwave radiometry measurements in terms of brightness temperature and consequently soil moisture retrievals.
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge

We have previously shown that macaques vaccinated with DNA vectors expressing SIVmac239 antigens developed potent immune responses able to reduce viremia upon high-dose SIVmac251 challenge. To further improve vaccine-induced immunity and protection, we combined the SIVmac239 DNA vaccine with protein immunization using inactivated SIVmac239 viral particles as protein source. Twenty-six weeks after the last vaccination, the animals were challenged intrarectally at weekly intervals with a titrated dose of the heterologous SIVsmE660. Two of DNA-protein coimmunized macaques did not become infected after 14 challenges, but all controls were infected by 11 challenges. Vaccinated macaques showed modest protection from SIVsmE660 acquisition compared with naïve controls (P = 0.050; stratified for TRIM5α genotype). Vaccinees had significantly lower peak (1.6 log, P = 0.0048) and chronic phase viremia (P = 0.044), with 73% of the vaccinees suppressing viral replication to levels below assay detection during the 40-wk follow-up. Vaccine-induced immune responses associated significantly with virus control: binding antibody titers and the presence of rectal IgG to SIVsmE660 Env correlated with delayed SIVsmE660 acquisition; SIV-specific cytotoxic T cells, prechallenge CD4+ effector memory, and postchallenge CD8+ transitional memory cells correlated with control of viremia. Thus, SIVmac239 DNA and protein-based vaccine protocols were able to achieve high, persistent, broad, and effective cellular and humoral immune responses able to delay heterologous SIVsmE660 infection and to provide long-term control of viremia. These studies support a role of DNA and protein-based vaccines for development of an efficacious HIV/AIDS vaccine.
Letter: is nucleoside analogue treatment associated with a reduction in overall liver cancer incidence?

sis. First, Jiang and colleagues inferred the risk for HCC based on the pooled proportion of the participants who developed HCC across all of the studies. Although the proportion of participants developing HCC approximates the cumulative HCC incidence within each study, pooling the proportions across studies requires adjusting for differences in the duration of follow-up between the studies. The incidence rate would be the appropriate measure of risk for the meta-analysis because it accounts for follow-up duration. The original studies included by Jiang et al. provided the duration of follow-up necessary to calculate incidence rates. Second, it appears that the meta-analysis by Jiang and colleagues did not to account for potential confounding variables. Many of the original studies included in their meta-analysis only reported the HCC incidence for participants who had HBsAg seroclearance. To estimate risk reduction, Jiang and colleagues formed a comparison group by combining participants from the subset of studies that also followed persons without HBsAg seroclearance. The pooled group of persons with and without HBsAg seroclearance analysed by Jiang and colleagues may not be directly comparable because of substantial heterogeneity among the studies, such as differences in the study populations (age, sex, HBV genotype), study settings (clinic-based vs. population-based), and participants’ experience with HBV therapy. 5–7 Liu et al. combined relative risk estimates in the original meta-analysis, which would have reduced potential confounding by maintaining a comparator group that was similar to the exposure group. Because conducting meta-analyses requires careful epidemiologic consideration of the original studies, we encourage the use of established guidelines for conducting a systematic review and meta-analysis. 9
The Structural Difference of Shanghai Stock Index before and after 2008: A Copula Based Analysis

The year 2008 witnessed the greatest joint stock reform and financial crisis in Chinese history. After these two cases, significant changes have taken place in investors’ behaviors worldwide, along with which is the occurrence of structure change in stock market. In this paper, we employ copula model to simulate the joint distribution between Shanghai Stock Index (SSE) and Chinese Shanghai Index 300 (CSI 300), to find out structure change in Chinese stock market before and after 2008. From results of empirical studies, we get conclusions that the main nature of Chinese stocks market is symmetric, in both marginal and joint distributions. Via the changes of Copula types, upper and lower tail coefficients and Kendall coefficients, we can measure the structure change in Chinese stock market, and get further conclusion about investors’ behaviors change. Before 2008, there is an equal power in quitting market and longing, while diversified investors adjusted their expectation uniformly after this year. Testing results show that the general dependence structure of CSI 300 and SSE is highly dependent and symmetric in most cases. From the distribution of upper and lower tail coefficients, we can draw the conclusion that stratified investors are mainly focused on two tasks, after this year, to close the position on stocks with high correlated stocks market and to maintain market value of stocks.
HIV Diagnosis Disclosure: Stigma Management and Stigma Resistance

This article reports diagnosis disclosure decision comments arising serendipitously in five focus group discussions with 34 HIV-infected New Yorkers over age 50. Three overarching disclosure themes demonstrate the complexity of diagnosis disclosure decision-making: (a) hiding or selectively disclosing, or stigma management; (b) partial disclosure because of the perception of partial control of the information; and (c) widespread or complete voluntary diagnosis disclosure, representing stigma resistance. Social workers and other human services practitioners should remember the diversity in the HIV population, the aging population, and the HIV-positive aging population. Experiences of HIV stigma and choices about diagnosis disclosure and stigma management or resistance are individual, reciprocal, and dynamic.
The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs

Background: Extrapyramidal signs (EPS) are common in Alzheimer disease (AD) and increase in prevalence as AD advances. The neuropathologic substrate responsible for EPS in AD remains to be fully characterized. Methods: Subjects had a clinical diagnosis of AD confirmed by neuropathologic examination. EPS during life were documented by clinical methods assessing bradykinesia, cogwheel rigidity, rest tremor, and parkinsonian gait. Subjects with EPS and previous neuroleptic exposure were excluded. Twenty-eight subjects were in the EPS group and 104 subjects were without EPS. Neuron loss, α-synuclein (ASYN)-labeled pathology, and tau-labeled pathology in the substantia nigra were measured using semiquantitative techniques such that higher scores represented increased pathologic burden. Results: Presence of nigral ASYN-labeled pathology was more common (50 vs 28.9%; p < 0.05) in the EPS group than in those without EPS. There was more nigral neuron loss in the EPS group (1.50 vs 1.11 in no-EPS group; p < 0.05). Tau-labeled burden was not different by group comparisons; however, EPS onset at later stages of dementia severity was associated with increased tau-labeled pathology (Kendall tau-B = 0.48, p < 0.01) and this association remained after controlling for dementia severity at death. Additionally, moderate to severe tau burden was more common in the subgroup with “pure AD” (definite AD without other neuropathology) with EPS (81.8%) than cases without EPS (49.0%; p < 0.05). Four subjects with EPS (14.3%) had little to no significant nigral pathologic changes. Conclusions: Clinically detected extrapyramidal signs (EPS) in Alzheimer disease (AD) are associated with substantia nigra pathology including α-synuclein aggregation, hyperphosphorylated tau accumulation, and neuron loss that may account for the increasing prevalence of EPS as AD progresses. In some cases, limited nigral pathology suggests extranigral factors in the clinical symptoms of EPS.
Analysis of age groups and motion speed using smart phone accelerometers

The growth of cellular technology has opened doors to many fields of research, one of these being the testing and analyzing of sensors found in almost all smart phones. The data collected from these sensors is analyzed to provide sensitive information about the user. One of these sensors, the accelerometer, is a powerful device that is used to record acceleration along the three axes. The readings obtained from this device can be analyzed to estimate the motion speed and the age group of an individual. This paper depicts a detailed study of the smart phone accelerometer values of individuals whose ages span over a wide range, for four levels of motion mainly, walking, slow running, normal running and fast running. Three parameters, mean peak time, average acceleration and maximum acceleration were used to test the collected data. The accelerometer values for the three parameters obtained, per age group, per motion speed were analyzed and several observations were noted. Observations of those parameters that stood out for a particular age group and those parameters that differed from one age group to another were also made.
Public health. China takes aim at rampant antibiotic resistance.

The Chinese government is leading a crusade to warn its people against the perils of frivolous antibiotic consumption. The campaign culminated last week in a Health Ministry directive laying out stricter regulations for prescription drugs. Bacteria that cannot be stopped by common drugs are proliferating around the world. But a health care system that encourages doctors to churn out prescriptions, intensive marketing by pharmaceutical companies, and heavy use of antibiotics in animal husbandry and fisheries make China a special case. China9s health ministry hopes to ward off calamitous outbreaks of drug-resistant strains.
Cyber Dating Abuse: Prevalence, Context, and Relationship with Offline Dating Aggression

The use of information and communication technologies (ICT) as tools to intimidate, harass, and control the partner has been, so far, little studied in the literature. The aim of this study was to determine the extension and sex differences of victimization of cyber dating abuse, as well as the context in which it occurs, and its relationship with offline psychological and physical aggressions. The sample consisted of 433 college students ages 18 to 30 years. The results showed that over 50% of the participants had been victims of some type of cyber dating abuse in the last six months. The most common behavior was the use of ICT to control the partner. Also, victims of cyber dating abuse were victimized repeatedly, an average of 23 times in the last six months. The data also showed that cyber dating abuse appear usually in a context of jealousy. Finally, the results revealed a significant relationship between cyber dating abuse and offline psychological dating aggressions. Limitations and future lines of research are discussed.
Comparison of Bupivacaine‐and Ropivacaine‐Induced Conduction Blockade in the Isolated Rabbit Vagus Nerve

Ropivacaine (LEA-103) is a new amino-amide local anesthetic agent the chemical structure and anesthetic properties of which are similar to bupivacaine. Preliminary studies in animals indicate that the CNS toxicities of ropivacaine and bupivacaine are similar, but that ropivacaine may have less arrhythmogenic effects than bupivacaine. The current study was designed to compare the in vitro potency, onset and recovery from block of ropivacaine and bupivacaine using an isolated rabbit vagus nerve model. The effect of varying concentrations of ropivacaine and bupivacaine on the compound action potential of A and C nerve fibers was assessed to determine whether motor and sensory fibers have different sensitivities to the two agents. The results showed that the depressant effect of bupivacaine was 16% greater than that of ropivacaine on motor fibers, but only 3% greater on sensory fibers. An analysis of variance indicated that this was a statistically significant difference (P=0.028). Thus, at the concentrations tested, ropivacaine appears to produce relatively less blockade of motor fibers than does bupivacaine but with similar sensory blockade. The onset of this difference became significant as early as five minutes after the drug exposure was begun. No significant differences in recovery times were observed.