Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction between grid-connected PV systems and LED lamps: Directions for further research on harmonics and supraharmonics

This paper discusses different approaches to investigate the interaction through harmonics, interharmonics, supraharmonics, and light flicker, between photovoltaic (PV) inverters and LED lamps in low-voltage installations. Single grid-connected power generators and electronic loads like LED lamps can be easily characterized in terms of harmonics in a given range of frequency. This subject is relatively well understood, and specific standards for measuring and restricting emissions are already established to ensure a low probability of interference. However, when connected together, source and load exhibit behavior that requires further study and understanding. This work presents a discussion serving as a guide for future work on analysis of losses and other impacts of the disturbances regarding this specific load and source interaction. The following are taken into account: the nonlinearity of LED loads and PV converters; the technologies and methods used in control; and the changes in power flow caused by load and power production variations.
Preoperative Histological Subtype Classification of Intraductal Papillary Mucinous Neoplasms (IPMN) by Pancreatic Juice Cytology With MUC Stain

Objective:To prospectively evaluate the diagnostic value of preoperative histological subtyping of intraductal papillary mucinous neoplasms (IPMNs) by pancreatic juice cytology (PJC) with mucin (MUC) stain. Background:IPMNs are classified into four subtypes based on their histomorphology and mucin phenotype, and varied degrees of malignant nature and prognosis among these subtypes have been shown. Methods:The subjects were 36 patients with surgically confirmed IPMNs, who underwent PJC preoperatively by endoscopic retrograde cholangiopancreatography. Histological subtyping of cytological samples with or without MUC stain (MUC1, MUC2, and MUC5AC) was compared with that of resected specimens. Results:Histologically, low-grade dysplasia was found in 4 patients, intermediate in 10, high grade in 11, and invasive carcinoma in 11. Gastric, intestinal, pancreatobiliary, and oncocytic subtypes corresponded to 16, 14, 5, and 1 patient, respectively. The rate of high-grade dysplasia (HGD) and/or invasive IPMNs was 25% for gastric subtype, 85.7% for intestinal subtype, and 100% for both pancreatobiliary and oncocytic subtypes, showing a significant correlation between histological subtype and rate of HGD and/or invasive IPMN (P < 0.01 for gastric vs nongastric). Histological subtype was successfully diagnosed by PJC in 42% (15/36) without MUC stain, and the rate was significantly improved to 89% (32/36) with MUC stain (P < 0.01). The sensitivity, specificity, and overall accuracy of PJC with MUC stain were 86%, 100%, and 94% for intestinal subtype, respectively. When cytological grade was combined with MUC stain, the diagnosis of HGD/invasive IPMN showed 77.2% sensitivity, 85.7% specificity, and 80.5% accuracy. Conclusions:Preoperative PJC with MUC stain proved to be highly reliable for identifying the histological subtype of IPMN and may provide useful information for deciding surgical indication.
Hybrid Harmonic Averaging Operator and its Application to Decision Making

By combining the advantage of the weighted harmonic averaging (WHA) operator and ordered weighted harmonic averaging (OWHA) operator, this paper first develops hybrid harmonic averaging (HHA) operator for aggregating data information, and then proposes a HHA operator-based method for multiple attribute decision making(MADM) problems. The HHA operator generalizes both the WHA and OWHA operators, and reflects the importance degrees of both the given argument and the ordered position of the argument. Finally, a numerical example is used to illustrate the applicability and effectiveness of the proposed method.
Contact by melanoma cells causes malignant transformation of human epithelial-like stem cells via alpha V integrin activation of transforming growth factor β1 signaling

The embryonic microenvironment is known to suppress the tumorigenic phenotype of aggressive cancer cells; however, the effects of tumorigenic microenvironments on stem cells have not been sufficiently explored due to the lack of suitable model systems. In order to study the tumorigenic microenviornment, we developed a novel in vitro model system for induction of malignant transformation of human epithelial-like stem cells (hEpSCs), involving co-cultivation and close contact of hEpSCs with the A375 melanoma cell line, together with mutagen treatment of hEpSCs with dimethylbenzanthracene (DMBA). Both factors (close contact and mutagen treatment) were required to transform hEpSCs in vitro and cause phenotypic changes characteristic of epithelial to mesenchymal transition (EMT), including colony formation, decreased E-cadherin and increased N-cadherin and vimentin expression. Direct contact between tumor cells and hEpSCs treated with DMBA increased integrin alpha V (ITGAV gene) expression and caused local activation of the transforming growth factor (TGF)-β1/Smad signaling pathways in hEpSCs. The novel model system described here is being used to elucidate the microenvironmental factors and biological mechanisms involved in the induction of neoplastic progression in hEpSCs in vitro by A375 melanoma cells. A better understanding of the molecular mechanisms by which melanoma cells exert these effects on hEpSCs may open up new avenues for therapeutic and preventive cancer interventions.
A distributed layered modulation for relay downlink cooperative transmission

In downlink relay systems, the conventional straightforward relaying scheme named decode-and-forward (DF) protocol is used at relay station (RS) to decode the data received from base station (BS) and forward the decoded data to the mobile station (MS) to improve the spatial diversity gain. However, conventional DF mode is spectral inefficient and not capacity optimal since the wireless channels in BS-to-RS, BS-to-MS, and RS-to-MS links are asymmetric, i.e., different channel qualities are obtained in different links in the practical scenario. In this paper, a distributed layered-modulation scheme is proposed to improve the DF mode performance in the presence of asymmetric links. With this proposed scheme, BS and/or RS transmit/re-transmit a layered modulated signal comprising a higher-order and a lower-order modulation components according to the different channel conditions in BS-to-RS and RS-to-MS links, respectively, and, therefore, the channel capacity of each link can be utilized efficiently. In addition, a two-layer demodulation is proposed at the destination by exploiting the two copies of transmitted packet from BS and RS, respectively. In order to further enhance the decoding performance, a soft combining method, in which the bit Log Likelihood Ratio (LLR) of the signals that received during the broadcast phase and the relaying phase are combined before turbo decoding, is used at MS receiver. Simulation results show that the proposed distributed layered modulation scheme obtains a significant performance gain in terms of block error rate (BLER) compared to the existing DF relaying scheme.
Dose-Rate Effectiveness for Unstable-Type Chromosome Aberrations Detected in Mice after Continuous Irradiation with Low-Dose-Rate γ Rays

Abstract Tanaka, K. , Kohda, A. , Satoh, K. , Toyokawa, T. , Ichinohe, K. , Ohtaki, M. and Oghiso, Y. Dose-Rate Effectiveness for Unstable-Type Chromosome Aberrations Detected in Mice after Continuous Irradiation with Low-Dose-Rate γ Rays. Radiat. Res. 171, 290–301 (2009). Chronological changes in the chromosome aberration rates of splenocytes from specific-pathogen-free (SPF) mice after continuous and long-term exposure to low-dose-rate γ rays were studied. Incidences of dicentrics plus centric rings (Dic+Rc), detected by conventional Giemsa staining, and dicentric chromosomes, detected by fluorescence in situ hybridization (Dic by FISH) using a centromere probe, showed an essentially linear increase up to a total accumulated dose of 8000 mGy after irradiation for about 400 days at a low dose rate of 20 mGy/day. For comparison, acute high-dose-rate and medium-dose-rate irradiation were performed. The values of the α coefficients in the linear regression lines for these unstable-type aberrations decreased as the dose rates were lowered from medium dose rates (200 and 400 mGy/day) to low dose rates (1 and 20 mGy/day). The dose and dose-rate effectiveness factor (DDREF), estimated by the ratio of calculated incidences using the best-fit regression lines at a high dose rate (890 mGy/min) and low dose rate (20 mGy/day), was 4.5 for Dic by FISH and 5.2 for Dic+Rc, respectively, at the same dose of 100 mGy, while different DDREFs were obtained for different accumulated doses. This is the first study to provide information regarding the effects of long-term exposure to low-dose-rate radiation on chromosomes.
Determining the impact of establishing a psychogeriatric outreach team network in long-term care.

OBJECTIVES The primary objective of this study was to describe a model for specialized psychogeriatric consultation to long-term care homes in a large metropolitan Canadian city and to provide an overview of the diagnostic and demographic data of patients referred for assessment. METHODS Forty long-term care homes and 13 geriatric mental health outreach teams were surveyed and provided feedback on the model. A retrospective chart review (N=88) was also conducted to confirm the survey results and to provide an overview of the types of patients being seen. RESULTS Team data indicated that 96% of the homes they served (N=81) were using their services, that all referrals were appropriate, and that their recommendations were implemented in over 50% of cases. Referred patients tended to be older (41% age 85 or older); were referred mainly for agitation, aggression, or depressed mood (over 90%); and mainly had a mood or cognitive disorder (over 90%). CONCLUSIONS These preliminary data suggest that the implementation of specialized psychogeriatric consultation to long-term care may be beneficial, but future studies are required to clarify its usefulness.
Verdoorn’s law and productivity dynamics: An empirical investigation into the demand and supply approaches

ABSTRACT According to Verdoorn’s law, productivity growth is endogenous to output growth, due to the existence of increasing returns to scale, broadly defined. Such an idea is at the root of both the endogenous growth theory and the Kaldorian approach. While in Kaldor’s view, a country’s growth is demand-driven, in the endogenous growth theory, growth is determined by the growth of the factors of production and hence growth is supply-constrained. This article empirically tests both assumptions for Verdoorn’s law by using a dynamic panel of manufacturing industries for seventy countries at different stages of development for the years between 1963 and 2009. In order to distinguish between these approaches, two different specifications are estimated where the growth of output and the supply of factors of production are instrumentalized by system generalized method of moments (GMM)estimators. The results show that, if it is assumed that the growth rates of countries are demand-driven, a faster growth of output increases productivity growth due to the existence of increasing returns. Alternatively, if it is assumed that output growth is driven by the growth of the supply of the factors of production, it is not possible to conclude that productivity growth is induced by output growth.
The Selenium Status in Thalassemia Patients in South East of Iran

Introduction There are limited reports about selenium status in major thalassemia patients. The aim of this study is evaluation of selenium status in patients with major thalassemia south east of Iran with large sample size and wide range of age. This study compared selenium status with other sites of the world. Methods In this study 369 cases that had major thalassemia for more than 5 years were enrolled in the study. Selenium level was measured in all eligible patients after 12 hours fasting by graphite enstrum furnace atomic absorption spectrometry in south east of Iran in 2012. Results Of 369 cases, 333 eligible patients were evaluated. Mean age was 15.63±7.4 years. One hundred ninety two cases were male and others were female (141 Cases). About 27% (90) of the cases were 5-10 years-old, 24 % (80) were 10-15 years-old and 49% were more than 15 years-old. Iron chelator in 62.2% was Dessferrioxamine, in 15.5% was Deferiprone and in 22.3% was combination of Dessferioxamine and Deferiprone. Totally 85 cases (25.52%) had Selenium deficiency, 35.43% (118 cases) had normal levels and 39 %(130 cases) had selenium excess. Conclusion Our study on 333 major thalassemia cases documented variable status of selenium from deficiency to higher than normal levels. It was different with other reports in the world.
Allocation of harvest between user groups in a fishery with habitat effect

The destructive impacts of fishing on marine habitats may be mitigated through the allocation of catch shares between different user groups. We assess the optimal allocation of harvest across multiple user groups and how fishery outcomes are affected when catch shares are allocated suboptimally. We incorporate the harvest allocation process into a bioeconomic model in which fishing‐induced habitat damage occurs and a single fish stock is targeted by two user groups characterized by fishing technologies of differing environmental impact. Results show that maximizing the overall profit of the fishery often requires the catch share of one of the groups to be set at zero. The effects on biological and economic outcomes of deviating from this allocation to ensure positive catch shares for all groups depend on the strength of habitat–fishery interactions, difference in fishing costs, and whether the suboptimal allocation is made to the high or low impact group.
A novel survey towards various energy models with Ad Hoc On Demand Distance Vector Routing Protocol (AODV)

Most ad hoc mobile devices today operate on batteries. Hence, power consumption becomes an important issue. To maximize the lifetime of ad hoc mobile networks, the power consumption rate of each node must be evenly distributed, and the overall transmission power for each connection request must be minimized. These two objectives cannot be satisfied simultaneously by employing routing algorithms proposed in previous work. We propose a novel Survey which compare the performance of different types of power-related routing algorithms via simulation. Simulation results confirm the need to strike a balance in attaining service availability performance of the whole network.
Is it Time to Introduce Repetitive Transcranial Magnetic Stimulation into Standard Clinical Practice for the Treatment of Depressive Disorders?

Objective: To examine issues relating to the potential introduction of repetitive transcranial magnetic stimulation (rTMS) into clinical practice as a treatment for depression. Method: A review of the outcomes literature accompanied by an analysis of issues relating to the potential advantages and pitfalls of the introduction of rTMS as a treatment strategy. Results: Evidence is progressively accumulating that rTMS has antidepressant properties that are clinically relevant. These effects are biologically plausible and supported by basic research. Patients with therapy-resistant depression have few treatment alternatives and experience significant suffering, thus justifying the early introduction of a new treatment such as rTMS for this patient group. However, this must be balanced by a need to foster considerable further research and not to raise expectations unreasonably. Conclusions: It is timely for rTMS to be made more available to patients with treatment-resistant mood disorders. This need not be limited to clinical research trials but should only occur in medical settings where continual evaluation and research is conducted.
Changes induced in the permeability barrier of the yeast plasma membrane by cupric ion

A specific effect of Cu2+ eliciting selective changes in the permeability of intact Saccharomyces cerevisiae cells is described. When 100 microM CuCl2 was added to a cell suspension in a buffer of low ionic strength, the permeability barrier of the plasma membranes of the cells was lost within 2 min at 25 degrees C. The release of amino acids was partial, and the composition of the amino acids released was different from that of those retained in the cells. Mostly glutamate was released, but arginine was mainly retained in the cells. Cellular K+ was released rapidly after CuCl2 addition, but 30% of the total K+ was retained in the cells. These and other observations suggested that Cu2+ caused selective lesions of the permeability barrier of the plasma membrane but did not affect the permeability of the vacuolar membrane. These selective changes were not induced by the other divalent cations tested. A novel and simple method for differential extraction of vacuolar and cytosolic amino acid pools by Cu2+ treatment was established. When Ca2+ was added to Cu2+-treated cells, a large amount of Ca2+ was sequestered into vacuoles, with formation of an inclusion of a Ca2+-polyphosphate complex in the vacuoles. Cu2+-treated cells also showed enhanced uptake of basic amino acids and S-adenosylmethionine. The transport of these substrates showed saturable kinetics with low affinities, reflecting the vacuolar transport process in situ. With Cu2+ treatment, selective leakage of K+ from the cytosolic compartment appears to create a large concentration gradient of K+ across the vacuolar membrane and generates an inside-negative membrane potential, which may provide a driving force of uptake of positively charged substances into vacuoles. Cu2+ treatment provides a useful in situ method for investigating the mechanisms of differential solute pool formation and specific transport phenomena across the vacuolar membrane.
Automated fluorescent in situ hybridization (FISH) analysis of t(9;22)(q34;q11) in interphase nuclei

For chronic myeloid leukemia, the FISH detection of t(9;22)(q34;q11) in interphase nuclei of peripheral leukocytes is an alternative method to bone marrow karyotyping for monitoring treatment. With automation, several drawbacks of manual analysis may be circumvented. In this article, the capabilities of a commercially available automated image acquisition and analysis system were determined by detecting t(9;22)(q34;q11) in interphase nuclei of peripheral leukocytes.
Impaired cAMP and Rac 1 Signaling Contribute to TNF‐α‐induced Endothelial Barrier Breakdown in Microvascular Endothelium

Objective: In sepsis, tumor necrosis factor‐alpha (TNF‐α) contributes to endothelial barrier breakdown. The involvement of Rho A/rho kinase signaling has recently been challenged. Here, we tested the role of cAMP and Rac 1 signaling. Materials and Methods: For this study, we took in vivo measurements of hydraulic conductivity in postcapillary mesenteric venules of adult rats. Measurements of transendothelial electrical resistence (TER), fluorescein isothiocyanate–dextran flux, Western blotting, immunostaining, and enzyme‐linked immunosorbent assay–based measurements of cAMP levels and Rho‐GTPase activity in human microvascular endothelial cells. Results: TNF‐α disrupted endothelial barrier functions in vivo and in vitro. Under these conditions, Rho A activity was significantly increased, whereas Rac 1 activity was decreased and Cdc42 was unaltered. Moreover, cAMP levels were reduced. Rho kinase inhibition, using Y27632, did not prevent TNF‐α‐induced barrier breakdown. In contrast, preincubation with forskolin and rolipram (F/R) to increase cAMP and cytotoxic necrotizing factor 1 to activate Rac 1 and Rho A abolished TNF‐α‐induced barrier breakdown in vivo and in vitro. Moreover, inactivation of Rac 1 was blocked by F/R‐mediated increase of cAMP, whereas Rho A activation was only partially inhibited. Conclusion: Our data indicate that decrease of cAMP and Rac 1 inactivation, rather than Rho A activation, contribute to TNF‐α‐induced endothelial barrier breakdown in vivo and in vitro.
Developing narrative interpretation: structural and content analyses.

BACKGROUND Narrative thought is a primary mode of human cognition that underpins key human capabilities such as meaning-making and social-psychological understanding. AIMS We sought to further our understanding of the development of narrative thought during adolescence, particularly in terms of the structure and content of narrative interpretations. SAMPLE Participants were 151 grade 4 to grade 12 students from six schools in a major urban centre in Western Canada. They included average and high-average students. METHODS A cross-sectional design was used with four age groups: 10, 12, 14 and 17 years. Participants read a short story incorporating two substories and multiple layers of meaning. They then summarized it, described the two main characters, generated story morals and answered multiple choice interpretation questions. Responses were scored for both structural complexity and social-psychological content of narrative thought. Multivariate and univariate analyses of variance were conducted to identify developmental trends. RESULTS A clear developmental pattern in structural complexity was discerned in which students were increasingly able to understand complex multiple layers of meaning within a story. A striking shift in social-psychological thought was also identified as students demonstrated understanding that moved from an intentional focus on immediate and specific mental states to an increasingly interpretive focus on enduring states, character traits and second-order psychological interpretations. CONCLUSION Significant transformation occurs during adolescence in the structure and content of narrative thought as well as in capacity for the fundamental human endeavour of meaning-making.
Compensation of non-reciprocal interference in adaptive MIMO-OFDM cellular systems

In a time-division-duplex communication system, the channel knowledge can be obtained at the transmitter side due to channel reciprocity and it can be used to increase the spectral efficiency of a multiple-input multiple-output (MIMO) communications. However, the interference structure between transmission directions does not necessarily correlate. The obtained quality of service at the receiver may differ significantly from the desired one if the transmission parameters are assigned based on the reverse link measurements only. In this paper, the performance of an orthogonal frequency division multiplexing (OFDM) cellular system with adaptive MIMO transmission is studied in the presence of non-reciprocal inter-cell interference when the downlink interference structure is known at the receiver and only limited feedback information about the interference is available at the transmitter. The results are compared to those with perfectly known interference structure per each sub-carrier. The system level impact of realistic interference non-reciprocity scenarios is studied via network simulations. Linear minimum mean squared error (MMSE) filter is applied at the receiver to suppress the impact of structured inter-cell interference together with a simple and bandwidth efficient closed-loop compensation algorithm. Both link and system level simulation results show that the proposed compensation algorithm with a simple scalar power offset feedback combined with interference suppression at the receiver results in nearly the same performance as the ideal case