Miracle-dz/UniFAR-FTUs huggingface dataset:
Abstract OT2-01-04: Freezing instead of resection of small breast tumors (FROST): A study of cryoablation in the management of early stage breast cancer

Background/Objective: ACOSOG Z1072 demonstrated complete target tumor ablation in 92% of stage I invasive breast cancers treated with cryoablation prior to resection. We hypothesize that cryoablation can achieve complete tumor ablation and adequate local control in a selected population of women with early stage invasive breast cancer managed with cryoablation alone, without planned surgical resection. Methods: The trial is a phase II, single-arm, multicenter study open to women age 50 and older with core needle biopsy-proven clinical stage I, T1, clinically node negative (N0), unifocal, hormone receptor positive, HER2/neu-negative invasive ductal carcinoma measuring ≤1.5 cm by mammography (MG), ultrasound (US), and MRI. Once registered, subjects will undergo US-guided cryoablation followed 6 months later by an US-guided core biopsy of the cryoablated lesion to confirm the absence of residual viable disease. Following cryoablation, subjects will also begin a minimum 5-year course of adjuvant endocrine therapy and serial MG, US, and MRI. Whole breast radiotherapy (WBRT) is optional for subjects age 70+ (stratum I) and mandatory for women age 50-69 (stratum 2). Sentinel node biopsy (SNBx) is optional in both cohorts. All subjects found to have residual or recurrent disease will undergo standard surgical resection. The trial was activated in June 2016. The study is currently open at 6 sites with up to 30 sites planned. A total of 110 eligible subjects will be enrolled in each stratum for total accrual goal of 220. Enrollment is planned over 3 years followed by 5 years of follow-up. Results: The primary endpoint of the study will be to determine the rate of complete tumor ablation in patients treated with cryoablation, defined as absence of residual viable carcinoma detected by core needle biopsy of the ablation site performed 6-months post-cryoablation. The secondary endpoint will be to determine the 5-year ipsilateral breast tumor recurrence rate in patients treated with cryoablation without subsequent resection. Local recurrence will be defined as recurrence of cancer within the index quadrant confirmed histologically by needle biopsy. Breast cosmesis (assessed by BCCT.core) and adverse events will also be evaluated. Conclusions: If the FROST Trial is successful at achieving complete ablation in ≥ 80% of study subjects, the trial will provide an important foundation for establishing cryoablation as an alternative to conventional therapy in selected women with early stage invasive breast cancer. If interested, please contact Pam Ellis, clinical coordinator, at (925)460-6080 or pellis@sanarus.com. Citation Format: Coronado GM, Ho ET, Holmes DR. Freezing instead of resection of small breast tumors (FROST): A study of cryoablation in the management of early stage breast cancer [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr OT2-01-04.
A continental measure of urbanness predicts avian response to local urbanization

Understanding species‐specific relationships with their environment is essential for ecology, biogeography and conservation biology. Moreover, understanding how these relationships change with spatial scale is critical to mitigating potential threats to biodiversity. But methods which measure inter‐specific variation in response to environmental parameters that are also generalizable across multiple spatial scales are scarce. We used broad‐scale avian citizen science data, over continental Australia, integrated with remotely‐sensed products, to produce a measure of urban‐tolerance for a given species at a continental‐scale. We then compared these urban‐tolerances to modelled responses to urbanization at a local‐scale, based on systematic sampling within four small cities. For 49 species which had sufficient data for modelling, we found a significant relationship (R² = 0.51) between continental‐scale urbanness and local‐scale urbanness. We also found that relatively few citizen science observations (~250) are necessary for reliable estimates of continental‐scale species‐specific urban scores to predict local‐scale response to urbanization. Our approach demonstrates the applicability of broad‐scale citizen science data, contrasting both the spatial grain and extent of standard point‐count surveys generally only conducted at small spatial scales. Continental‐scale responses in Australia are representative of small‐scale responses to urbanization among four small cities in Australia, suggesting that our method of producing species‐specific urban scores is robust and may be generalized to other locations lacking appropriate data.
Polymethylmethacrylate Venogram after Cemented Arthroplasty of the Hip. A Report of Seven Cases and Review of the Literature

We present seven patients with polymethylmethacrylate (PMMA) filling the veins accompanying the second perforating branch of the profunda femoris artery detected after primary cemented hip arthroplasty. All implants were cemented utilizing retrograde canal filling with a cement pistol and pressurization. No haemodynamic changes were observed throughout any of the procedures and all patients had an uneventful recovery and evolution. The presence of a PMMA venogram is an infrequent finding after cemented hip arthroplasty. In our seven cases it was not associated with higher peri-operative morbidity. Differential diagnoses must be made with cement extruded through incomplete fractures or through femoral screw holes, as treatment and weightbearing status may differ.
What makes the heart fail? New insights from defective genes

Dilated cardiomyopathy (DCM) is an idiopathic, genetically heterogeneous disorder characterized by heart failure and arrhythmia. Over the past decade, the molecular basis for DCM has been partially uncovered by discovery of mutation in genes encoding cystoskeletal, sarcomeric, nuclear membrane, and sarcoplasmic reticulum proteins. These findings have implicated pathogenic mechanisms whereby structural integrity, contractile force dynamics, and calcium regulation within the cardiac myocyte are perturbed. Recognition of dilated and hypertrophic cardiomyopathies as allelic disorders has provided the opportunity to identify genotype‐phenotype relationships and to gain new insight into pathways leading to cardiac failure and hypertrophy.
A Quality Improvement Project: Adopting the Standards of Best Practice in Simulation: Debriefing with PEARLS

Background There is evidence the best practices of simulation, specifically, the use of debriefing, will assist the new graduate nurse’s transition into the profession by increasing their clinical judgment. This quality improvement (QI) project explored the pedagogy of High Fidelity Simulation and Debriefing as a solution for the lag in New Graduate Nurse (NGN) practice readiness. The specific aims of this project were: 1) to teach the NGN residency educators how to implement Standard: Debriefing of the International Nursing Association for Clinical Simulation and Learning (INACSL) Standards of Best Practices: Simulation by focusing on the role of the debriefer; 2) to teach NGN residency educators to use the Promoting Excellence and Reflective Learning in Simulation (PEARLS) (Eppich & Cheng, 2015) methodology of debriefing; and 3) to assess if the Lasater Clinical Judgment Rubric (LCJR) is applicable for measuring NGNs’ clinical judgment development. Project Design This QI project examined the use of simulation and reflective debriefing on two groups: the residency educators and the NGN. The project employed two, single-comparison group pre/post testing to evaluate: 1) the effect PEARLS on educators’ debriefing effectiveness; 2) the use of PEARLS on NGN clinical judgment; 3) the applicability of the LCJR for evaluating the NGN development of clinical judgment. Eight NGN residency educators were taught to use PEARLS as a method to implement the INACSL Standard: Debriefing. The DASH instrument was used to for pre/post teaching comparison of educators’ debriefing efficiency and the LCJR was used to compare NGN clinical judgment. DEBRIEFING WITH PEARLS 3
Anodization as a promising surface treatment for drug delivery implants and a non-cytotoxic process for surface alteration: a pilot study.

Aim Surface treatments use industrial processes in which surface contamination can occur. In this context, this study aimed to demonstrate a surface treatment process, from laboratory samples and clinical implants, named anodizing, analyze their tendencies to surface contamination as well as their properties.Materials and Methods Laboratorial samples of pure titanium were anodized. Investigated by scanning microscopy (SEM), dispersive energy spectroscopy (EDS) and wettability tests. Four implant systems available in the current market were chosen by different surface treatments (anodizing, double acid etching and particle blasting) and investigated by SEM/EDS.Results Laboratory samples showed a nanomorphology surface, free of contaminants and good liquid/surface interaction. The implant system with anodization treatment did not present elements outside the standards. However, the implants treated with acid attack and blasting were found different chemical elements like aluminum and magnesium.Conclusions Anodizing proved to be a contaminant-free surface treatment both in the laboratory and clinical implants. In addition, its promising property of owning TiO2 nanotubes suggests an inherent evolution to biomedical implants for drug delivery systems other than all surface treatments developed to date.
Preliminary Findings to Support the Internal Consistency and Factor Structure of the Ferrari-Lynch-Vogel Listening Test (FLVLT)

ABSTRACT While many tools exist to assess student content knowledge, there are few that assess whether students display the critical listening skills necessary to interpret the quality of a speaker’s message at the college level. The following research provides preliminary evidence for the internal consistency and factor structure of a tool, the Ferrari-Lynch-Vogel Listening Test (FLVLT), designed to assess critical listening by community college students. FLVLT data was collected from 915 students over three academic years at an urban community college. The findings of this research provide some initial evidence for the FLVLT’s effectiveness at measuring critical listening by community college students. Future research should seek to expand the analysis of FLVLT’s reliability and provide some initial evidence of validity.
Attenuation of Hemodynamic Response during Laryngoscopy and Endotracheal Intubation: Effect of Clonidine and Dexmedetomidine

VIMSAR, BURLA Corresponding Author Dr Malaya Ku Patel VIMSAR, BURLA Abstract Background: Laryngoscopy and endotracheal intubation violate the patient’s protective airway reflexes and invariably cause hemodynamic changes associated with increased heart rate, increased blood pressure and occasional disturbance in cardiac rhythm. Aim: The aim of the study was to find the efficacy of α2-adrenoceptors agonist in attenuating pressor response while securing airway during surgery. Methods: Ninety patients of ASA physical status I and II, in the age group between 25and 50 years, of either sex, undergoing various elective abdominal surgeries under general anaesthesia were randomly allocated into three groups. Both clonidine and dexmedetomidine administered intravenously just before laryngoscopy and endotracheal intubation effectively attenuated the hemodynamic response by limiting the extent of rises in heart rate and blood pressure. Result: Dexmedetomidine has been found to provide better hemodynamic stability than clonidine.
Toward a unified theoretical framework for photogrammetry

ABSTRACT The objective of photogrammetry is to extract information from imagery. With the increasing interaction of sensing and computing technologies, the fundamentals of photogrammetry have undergone an evolutionary change in the past several decades. Numerous theoretical progresses and practical applications have been reported from traditionally different but related multiple disciplines, including computer vision, photogrammetry, computer graphics, pattern recognition, remote sensing and machine learning. This has gradually extended the boundary of traditional photogrammetry in both theory and practice. This paper introduces a new, holistic theoretical framework to describe various photogrammetric tasks and solutions. Under this framework, photogrammetry is generally regarded as a reversed imaging process formulated as a unified optimization problem. Depending on the variables to be determined through optimization, photogrammetric tasks are mostly divided into image space tasks, image-object space tasks and object space tasks, each being a special case of the general formulation. This paper presents representative solution approaches for each task. With this effort, we intend to advocate an imminent and necessary paradigm change in both research and learning of photogrammetry.
Digital marketing strategy in promoting product

A rapid internet development and its function has become one of the most important technologies in the world since it is very influential for human life. Considering this, one of the paid television companies makes an integrated marketing communication using internet as a tool for promoting its product. This study aims to know the role and strategy of various digital marketing channels, including website, search engine marketing (SEM), online PR, display advertising, email marketing and social media marketing in promoting product. The methodology is descriptive qualitative using interview and participant observation. The data were collected through documents and literature which related to digital marketing. This study found that digital marketing strategy has important role in promoting product. The whole digital marketing strategy, either in its planning, implementation, or evaluation, has its own uniqueness. It showed that digital marketing strategy has been run well within the company. JEL Classification: M31, M37, M39.
Applied measurement of the motor speed controller for washing machine with random loads, part II

This research presents a very important industrial issue of controlling the production target, despite changing loads. Engines of various types, whether synchronous or synchronous, operate on single and three phase AC, DC motors or special motors such as stepper and servo. In all these motors, the speed control of the torque and speed of the above motors has gained considerable importance. There are three main ways reviewed in the current search, the second that completes the previous research referred to in the references. The three methods are PID method, LQR method and feeding –forward control methods. A real DC motor was used in electrical engineering machine laboratory at University of Diyala, Iraq. Where the actual parameters of the DC motor were actually calculated. The practical parameters were then integrated into the three control method Matlab codes for the purpose of comparing the results and representing the motor performance in the indicated control methods.
Bodies, gender, and digital affect in fitspiration media

ABSTRACT This paper takes an affective approach to theorizing the production and circulation of fitspiration media within a women’s Instagram fitness community. In the context of fitness culture trends towards digitally networked, interactive, and quantified experiences, our study contributes to debates about the impacts of fitspiration media on women by investigating the expressions, feelings, and connections that arise through the self-presentation and circulation of “fit” body images on social media. We analyze 155 Instagram posts containing the hashtags #BBG, #thekaylamovement, #kaylasarmy, and #bbggirls to map the ways in which feelings are communicated by followers of a popular global fitness community led by celebrity influencer Kayla Itsines. In so doing, we reveal the ways in which intensities of feeling experienced in, through and about the body (i.e., pride, vulnerability, shame) work affectively to connect and compel exercising women.
High-Throughput Visual MIMO Systems for Screen-Camera Communications

Screen-camera communications, using a liquid crystal display (LCD) screen and camera image sensors, have been attractive variants of visible light communications (VLC) since any external light-emitting modules and photo detectors are required for recent mobile devices, which are usually equipped with display and camera. A major issue in screen-camera communications is a performance loss in transmission rate due to nonlinear channel impairments with ambient noise. To improve transmission rates, we investigate the impact of nonlinear channel equalization, nonbinary channel coding, probabilistic shaping, and nonlinear precoding for high-order modulation schemes. Experimental evaluations using an LCD screen and camera demonstrate that our proposed scheme achieves 3.8–3.3 times higher transmission rates compared to existing schemes for a communication distance of 60–160 cm.
Is Zumba® Fitness Effective to Manage Overweight Without Dietary Intervention?

Background: Zumba® Fitness is a popular aerobic exercise and sometimes due to its high-intensity is considered sufficient for weight management , , from both trainers and trainees , , regardless of the type of diet followed. Its effectiveness in weight and body fat loss , , with or without dietary intervention has been slightly studied. Subjects and Methods : In the current randomized controlled trial , , thirty two healthy adult overweight women who attended exclusively Zumba® fitness for three times per week , , were randomly divided into 3 subgroups and received parallel dietary advice for two months: Group A did not receive dietary intervention (control group) , . Group B received general healthy eating guidelines based on the Mediterranean pyramid and the food plate model and Group C individualized diet plan according anthropometric characteristics , , lifestyle , , and dietary habits. A Food Frequency Questionnaire used at baseline to assess dietary habits before the study , , and three 24-hour recalls evaluated compliance upon dietary intervention. Results : Significant reductions in body weight , , fat , , hip and waist circumference revealed in Group C , and in body fat of Group B. Conclusions : Zumba® fitness is enjoyable and could be used to enhance weight loss with appropriate dietary individualized advice in overweight subjects. In parallel , . it could be effective when combined with healthy eating guidance for improving fat loss and general well being.
A 0.5-V Capless LDO With 30-dB PSRR at 10-kHz Using a Lightweight Local Generated Supply

An analog low dropout regulator (LDO) that can operate at ultra-low voltage (ULV) with high power supply rejection ratio (PSRR) is presented in this brief. The supplies of the error amplifier and the power stage in this LDO are separated, and a lightweight local generated supply (LLGS) is proposed to guarantee the proper function of the associated error amplifier in ULV mode. This LLGS assisted analog LDO has been experimentally verified in 0.13 <inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> CMOS technology and it only occupies an active area of 0.035 mm<sup>2</sup>. Measurement results indicate that this LDO can achieve greater than 30 dB PSRR up to 10 kHz at supply voltage as low as 0.5 V.
Research and Development of Biopesticides: Challenges and Prospects

Even though pesticides have greatly contributed to boosting agricultural productivity and farmer income over the years, there have been concerns about the safety of some of these pest control products. Besides, there has been a growing demand for good quality and safe food in the recent past – as reflected in the stringent regulations on pesticide residue levels in produce. Biopesticides in comparison with conventional synthetic chemical pesticides are usually less toxic, generally affect only the target pest and closely related organisms, are often effective in relatively small quantities and decompose faster, resulting in lower exposure. Consequently, over the last few years, biopesticides have attracted global attention as a safer pest control strategy for incorporation into Integrated Pest Management (IPM) programmes. Besides, in the last decade, adoption of IPM programmes has significantly enhanced pest management practices and, in some cases, reduced pesticide use, consequently reducing the rise in demand for synthetic chemical pesticides. Also, the development of new synthetic chemical pesticides has declined considerably in the recent past, as regulations have become tighter, with products being withdrawn from the market, resulting in a more limited choice of chemical solutions such that biopesticides have become a more feasible option. Many countries have also increasingly lowered chemical Maximum Residue Levels for agricultural imports which have made it increasingly necessary to explore pest control options which would ensure reduced reliance on the use of synthetic chemical pesticides. In this paper, avenues of addressing challenges to biopesticide research and development are evaluated by seeking the inputs of a wide range of stakeholders, building on a recent international workshop with biopesticides practitioners from across the globe. Prospects for biopesticide application are detailed using a case study on the fall armyworm (Spodoptera frugiperda) in Africa.