Miracle-dz/UniFAR-FTUs huggingface dataset:
Mastitis in Dairy Cows Genotypes, Spread, and Infection Outcome of Three Important Udder Pathogens

Mastitis, inflammation of the udder, is a common disease among dairy cows worldwide. This thesis investigated the genotype variation and spread of three major udder pathogens: Staphylococcus aureus, Streptococcus dysgalactiae, and Streptococcus uberis. Isolates collected in a previous study of veterinary-treated clinical mastitis (VTCM) were used to study between-herd genotype variation in epidemiologically independent isolates and differences in outcome. Intramammary infections (IMI) were scrutinized for their occurrence on the day of calving and four days later by quarter milk sampling in selected herds with mastitis problems. The importance for long-term udder health and production of these IMI was also investigated. The two most common Staph. aureus genotypes among the VTCM isolates were detected in 64% of the herds. In contrast, none of almost 100 Strep. uberis isolates from different herds was of the same genotype. The Strep. dysgalactiae isolates varied moderately compared to the ones of Staph. aureus and Strep. uberis. The common genotypes of Staph. aureus were associated with a lower somatic cell count (SCC) during the follow-up period, compared to the less common genotypes. No differences were detected between genotypes of streptococci, but cows with Strep. dysgalactiae VTCM had a lower SCC during the follow-up period compared to those with Strep. uberis. In herds with mastitis problems, Staph. aureus was the most common pathogen found at and just after calving, followed by Strep. dysgalactiae, and Strep. uberis. Isolates of Staph. aureus showed the lowest within-herd genotype diversity, followed by an intermediate diversity of Strep. dysgalactiae and a high diversity of Strep. uberis. There was a marked variation in occurrence of IMI at or close to calving in herds with mastitis problems, indicating that the predisposing factors for udder infections at calving differed between herds. Most early lactation IMI were associated with an increase in lactation SCC, whereas associations with other outcome variables were more variable. Altogether, this thesis contributes knowledge about Staph. aureus, Strep. dysgalactiae, and Strep. uberis that can be used in preventive work against these IMI.
From Clinical-Developmental Theory to Assessment: The Holistic Student Assessment Tool

A description and test of the Holistic Student Assessment Tool (HSA), an assessment tool to measure children’s and adolescents’ resiliencies in relation to externalizing and internalizing problem behaviors. The HSA is based on the authors’ research-based clinical-developmental Clover Leaf Model of resilience and psychopathology, and is one of the first attempts at closing the gap between risk and resilience approaches in developmental assessment. The HSA was tested in a cross-sectional sample of 423 children and adolescents. The results lend support to the HSA as a valid measure of children’s and adolescents’ resiliencies. Furthermore, the resilience scales mostly exhibited the theoretically expected convergent and divergent relationships with the psychopathology scales. In addition, we show how the resilience scales predict adolescents’ externalizing and internalizing symptoms. We contend that evidence-based intervention to address youth aggression needs to be based on sound developmental assessment.
New low-voltage full wave rectification technique without a diode

Applications like signal detectors and sample and hold circuits in communication are dependent on low-voltage rectification. Normally, a diode is used as a rectifier having the drawback of rectification at a voltage below its threshold voltage. Here, the authors have proposed a new technique of full wave rectification without diodes operating at low input voltage and implemented on a printed circuit board. The circuit gives a dc output voltage almost same as peak input voltage with low harmonic distortion. The oscilloscope trace shows the output signal ~98 mV with ripple voltage 1 mV obtained with input voltage of amplitude, 100 mV at frequency 100 kHz.
Topical application of recombinant platelet‐derived growth factor increases the rate of healing and the level of proteins that regulate this response

A bipedicle ischaemic rat skin flap model was used to study the effects of daily topical applications of platelet‐derived growth factor (PDGF) on the healing of ischaemic wounds. Levels of tumour necrosis factor‐alpha (TNFA), interleukin 1‐beta (IL1B) and both the latent and active forms of matrix metalloproteinase 2 (MMP2) and 9 (MMP9) were measured. Full‐thickness wounds were made on a total of 72 adult male Sprague–Dawley rats. Each group of 18 rats with normal and ischaemic wounds received either vehicle or 0·01% recombinant PDGF‐BB. Additional applications were made on the wounds on a daily basis. Wound areas were measured at 0, 1, 3, 5, 7 9 and 13 days after wounding. Ischaemia caused a delay in wound healing as well as an increase in TNFA, IL1B and both the pro and active forms of MMP2 and MMP9. PDGF accelerated the rate of wound healing in both normal and ischaemic wounds and negated the effect of ischaemia. PDGF reduced the TNFA concentration in both normal and ischaemic wounds, and the rate of wound healing closely resembled the pattern of TNFA protein expression. PDGF also reduced both the magnitude and duration of the increases in IL1B and both the pro and active forms of MMP2 and MMP9 induced by ischaemia.
Mechanisms of antiviral immunity induced by a vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D: cytotoxic T cells

We used a transfected L cell and a vaccinia vector carrying the herpes simplex virus type 1 (HSV-1) gene coding for glycoprotein D (gD) to characterize HSV-specific T-cell responses. Various studies with mice revealed that the vectors could stimulate some HSV-specific T-cell responses. Although the majority of the T cells contributing to the HSV-1 gD-specific proliferative response were of the Lyt-2.1+ phenotype, cytotoxic T cells (Tc), surprisingly, were not induced by these gD vectors. Even though gD appeared to be a target for a class II major histocompatibility complex (MHC)-restricted killer cell, neither gD vector was capable of forming a target cell complex which could be recognized by class I MHC-restricted HSV-specific Tc. Further investigation of the gD-specific responses revealed the presence of potent suppressor cells and factors capable of inhibiting HSV-specific Tc induction in in vitro assays. One interpretation of these data is that class I MHC-restricted HSV- and gD-specific Tc do not develop during HSV infection because of active suppression.
Cooperative face hallucination using multiple references

This paper proposes a cooperative example-based face hallucination method using multiple references. The proposed method first uses clustering and residual prototype faces construction to improve the performance of hallucinating a single low-resolution (LR) face to obtain a high-resolution (HR) counterpart. In the case that multiple LR face images for a person are available, a unique feature of the proposed method is to cooperatively enhance the qualities of hallucinated HR images by taking into account the multiple input face images jointly as prior models. Experimental results demonstrate that the proposed cooperative method achieve significant subjective and objective improvement over single-prior schemes.
Homocysteine testing.

Professional Institutional Original Effective Date: March 13, 2009 Original Effective Date: March 13, 2009 Revision Date(s): August 17, 2010; August 12, 2011; June 29, 2012; March 31, 2014; February 24, 2016; October 1, 2016; October 1, 2017; July 1, 2019 Revision Date(s): September 16, 2010; August 12, 2011; June 29, 2012; March 31, 2014; February 24, 2016; October 1, 2016; October 1, 2017; July 1, 2019 Current Effective Date: July 1, 2019 Current Effective Date: July 1, 2019
Effects of the Oral Converting Enzyme Inhibitor (SQ 14225) on One-Kidney Hypertension in the Dog

Summary Angiotensin blockade was produced one day before and for 7 days after renal artery stenosis in three unilaterally nephrectomized dogs by administration of SQ 14225. The completeness of angiotensin blockade was demonstrated by reduced or absent pressor responses to exogenous angiotensin I and by a normal plasma aldoster-one level after renal artery stenosis. A depressor response (9 mm Hg) during the day before renal artery constriction and markedly exaggerated depressor responses to exogenous bolus injections of bradykinin after several days of SQ 14225 administration might reflect an increased plasma level of bradykinin but additional studies are needed on this idea. The arterial pressure response to renal artery constriction was markedly diminished during SQ 14225 and arterial pressure was not significantly elevated until the fifth day. PRA was elevated throughout the period of SQ 14225 administration and renal artery constriction. These findings confirm the earlier observations that the renin-angiotensin system need never be activated for the development and maintenance of chronic one-kidney renovascular hypertension.
Chemistry Education and Contributions from History and Philosophy of Science

Studies on history of chemistry have been largely focused on European and North American contexts (in spite of outstanding exceptions on China, India, and Japan). However, recent scandals regarding the mining of coltan minerals in Central Africa have raised public concerns about the consequences of modern chemical industries in postcolonial contexts. The awful conditions of workers in mines in South America have also attracted the interest of both public opinion and scholars. The author of this book deals with a similar but less known scenario. By adopting the perspective of social anthropology, Jerry K. Jacka provides a multifaceted examination of gold mining in Papua New Guinea and its social and cultural impacts during the second half of the twentieth century. While highlighting the important conflicts and tensions, the author firmly resists the temptation to embark on a morality tale of evil multinationals dispossessing people of their land and culture. On the contrary, he offers nuanced analysis based on both field-work interviews and historical archives. The main protagonists are the Porgeran people, whose lives experienced a massive social and environmental transformation after large-scale gold mining activities started in the 1960s. The narrative is organised around two main themes: resilience practices and competing ontologies. The author shows the creativity of Porgeran culture in order to adapt to the changes introduced by mining production. Indigenous conceptions of nature are described in the second part of the book through the concepts of land (Yu), people (Wandakali), and spirits (Yama). For Porgeran people, gold is a cosmological resource, and gold deposits are the result of the action of ancestral spirits. The author reviews how these cultural representations encountered new ideas coming from Christianity and free-market capitalism. In the third section, he explores resiliency and vulnerability in the face of the dramatic social and ecological changes. Finally, in the concluding chapter Jacka explores the potential policy implications of the study, while discussing more general issues concerning the intersection of competing ontologies, the agency of materials such as gold, and the impact of mining in Porgeran society and culture.
The relationship of the cell surface to metabolism. V. The role of uranium-complexing loci of yeast in metabolism.

Previous studies have shown that a number of phosphatasee are located on the cell surface of yeast. The present paper is concerned with the role of these enzymes in the over-all economy of the cell. By using molybdate or tungstate to inhibit the surface phosphatases, it was possible to show that these enzymes play no direct role in carbohydrate metabolism or in phosphate transport into the cell. However, experiments with phosphorylated sugars indicate that the cell surface phosphatases are able to split organic phosphates which the cell cannot utilize directly, into non-phosphorylated organic residues which the cells can utilize. The surface phosphatases thus play an indirect role in metabolism by enabling the cells to utilize phosphorylated compounds. THE RELATIONSHIP OF THE CELL SURFACE TO METABOLISM IV. THE ROLE OF CELL SURFACE PHOSPHATASES OF YEAST
Rilmenidine-induced ocular hypotension: role of imidazoline1 and alpha 2 receptors.

PURPOSE To examine ocular actions by rilmenidine, an imidazoline1 and alpha 2 adrenoceptor agonist. METHODS Intraocular pressure was measured in normal and sympathetically denervated rabbits by pneumatonometry. Electrically stimulated 3H-norepinephrine release from sympathetic nerves was determined in isolated, perfused rabbit iris-ciliary bodies. cAMP levels were evaluated in rabbit iris-ciliary bodies by radioimmunoassay. Ca2+ concentrations were measured in rabbit transformed nonpigmented ciliary epithelial cells by fluorescence ratio microscopy. RESULTS Topical, unilateral administration of rilmenidine produced hypotensive responses in normal rabbits which were antagonized by either bilaterally administered efaroxan, an imidazoline receptor antagonist or rauwolscine, an alpha 2 receptor antagonist. Sympathectomy also eliminated the ocular hypotensive response. Rilmenidine (0.001, 0.01, 0.1, 1 microM) caused 5 +/- 1%, 18 +/- 5%, 35 +/- 10%, and 48 +/- 9% inhibition, respectively, of 3H-norepinephrine overflow whereas 10 microM efaroxan or rauwolscine caused enhancement of norepinephrine release by 102 +/- 23% or 86 +/- 25%, respectively. Furthermore, pretreatment with efaroxan or rauwolscine partially antagonized the inhibition of norepinephrine release induced by rilmenidine. In other experiments, rilmenidine (1 microM) inhibited isoproterenol-stimulated cAMP accumulation in rabbit iris-ciliary bodies by 43 +/- 9% which was antagonized by 10 microM efaroxan or rauwolscine. Rilmenidine induced large increases in [Ca2+]i in rabbit nonpigmented ciliary epithelial cells which were effectively antagonized by efaroxan or rauwolscine. CONCLUSIONS These in vivo and in vitro data suggest that the ocular hypotensive activity induced by rilmenidine is due, in part, to suppression of sympathetic neuroeffector function in the rabbit ciliary body and that alpha 2 adrenergic receptors and/or imidazoline1 receptors are involved.
Beyond Happiness and Sadness: Affective Associations of Lyrics with Modality and Dynamics

A study is reported investigating the relationship between modality (major/minor) and dynamics (piano/forte) on four affects - as evident in the content of musical lyrics. Forty solo vocal works were sampled: 10 in the major mode with a loud (forte) dynamic level, 10 in the major mode with a quiet (piano) dynamic level, 10 in the minor mode with a loud dynamic level, and 10 in the minor mode with a quiet dynamic level. Sampled compositions were all tonal works from the Western vocal repertoire. Without hearing the music, 60 native-speakers of English, German, and French judged the language-appropriate lyrics according to four affects: sadness, happiness, passion, and tenderness. Results were consistent with predicted associations between minor-piano music and sadness, major-forte music and happiness, and minor- forte music and passion. A fourth predicted association between major-piano music and tenderness was skewed in the predicted direction, but was not statistically significant.
A NODE DEPLOYMENT MECHANISM FOR ENERGY-EFFICIENT ROUTING IN HETEROGENEOUS WIRELESS SENSOR NETWORKS

Military applications are the primary concern of the wireless sensor networks (WSNs). Efficient target object/event monitoring is a primary goal of military systems in unattended and unmanned areas. Heterogeneous wireless sensor network (HTWSN) is an emerging network for efficient enemy object monitoring in sensitive areas of low cost. The performance of HTWSN is mainly depends on the quality of data transmission and better network lifetime. However, after deployment of HTWSN, the network can experience a serious problem known as path failure. Path failure occurs due to high route overhead, which result poor-quality data transmission and increase the node energy consumption. Path failure results route rediscovery and data packet retransmission. The proposed node deployment mechanism for HTWSN has been minimized the route overhead and improved the path quality, quality data packet transmission by avoid the path failure. The proposed node deployment strategy has given better results in terms of 20 % low node energy consumption, 56 % lower route overhead, 22 % higher network lifetime and 17 % higher data packet delivery ratio than the existing node deployment mechanism of IMCC protocol.
Efficient Soft Tissue Modelling Using Charged Particle Control Points

As the performance levels of personal computers increases so does the desire for more realistic and immersive software and simulation. An area where this is particularly the case is that of medical training simulation, where there is an increasing demand for high fidelity virtual environments. However, realistically modeling of soft tissue deformation still poses a considerable challenge especially when haptic feedback is required. This paper presents a new approach to soft tissue deformation using a novel ‘Charged Particle’ method to control the haptic rendering while also adding a further level of realism by incorporating independent high resolution visualization to the simulation
Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia

Serotonin (5-HT) plays a critical role in modulating synaptic plasticity in the marine mollusc Aplysia and in the mammalian nervous system. In Aplysia sensory neurons, 5-HT can activate several signal cascades, including PKA and PKC, presumably via distinct types of G protein-coupled receptors. However, the molecular identities of these receptors have not yet been identified. We here report the cloning and functional characterization of a 5-HT receptor that is positively coupled to adenylyl cyclase in Aplysia neurons. The cloned receptor, 5-HTapAC1, stimulates the production of cAMP in HEK293T cells and in Xenopus oocytes. Moreover, the knockdown of 5-HTapAC1 expression by RNA interference blocked 5-HT-induced cAMP production in Aplysia sensory neurons and blocked synaptic facilitation in nondepressed or partially depressed sensory-to-motor neuron synapses. These data implicate 5-HTapAC1 as a major modulator of learning related synaptic facilitation in the direct sensory to motor neuron pathway of the gill withdrawal reflex.
Overview of the 4th Author Profiling Task at PAN 2016: Cross-Genre Evaluations

This overview presents the framework and the results of the Author Proﬁling task at PAN 2016. The objective was to predict age and gender from a cross-genre perspective. For this purpose a corpus from Twitter has been provided for training, and different corpora from social media, blogs, essays, and reviews have been provided for evaluation. Altogether, the approaches of 22 participants were evaluated.
Size at birth and adrenocortical function in childhood

OBJECTIVE The mechanisms underlying the association between reduced size at birth and cardiovascular disease and non‐insulin‐dependent diabetes mellitus in adult life are not known. One possibility is that the intra‐uterine environment has permanent effects on the function or activity of the hypothalamo‐pituitary‐adrenal axis. We tested this by relating size at birth to the urinary excretion of adrenal androgen and glucocorticoid metabolites in a population sample of 9‐year‐old children.
Indoor Pedestrian Navigation Based on Conditional Random Field Algorithm

Foot-mounted micro-electromechanical systems (MEMS) inertial sensors based on pedestrian navigation can be used for indoor localization. We previously developed a novel zero-velocity detection algorithm based on the variation in speed over a gait cycle, which can be used to correct positional errors. However, the accumulation of heading errors cannot be corrected and thus, the system suffers from considerable drift over time. In this paper, we propose a map-matching technique based on conditional random fields (CRFs). Observations are chosen as positions from the inertial navigation system (INS), with the length between two consecutive observations being the same. This is different from elsewhere in the literature where observations are chosen based on step length. Thus, only four states are used for each observation and only one feature function is employed based on the heading of the two positions. All these techniques can reduce the complexity of the algorithm. Finally, a feedback structure is employed in a sliding window to increase the accuracy of the algorithm. Experiments were conducted in two sites with a total of over 450 m in travelled distance and the results show that the algorithm can efficiently improve the long-term accuracy.
Central Sleep Apnea: Improvement With Acetazolamide Therapy

• Respiratory rhythm during sleep may be dependent on blood pH with apneas being associated with alkalosis. Acidification may therefore have therapeutic value in some forms of sleep apnea. We administered acetazolamide to six patients with symptomatic central sleep apnea, a disorder of respiratory rhythm with little or no upper airway obstruction. Sleep studies were carried out before and after one week of drug therapy, during which time the mean arterial pH decreased from 7.42 to 7.34. All six patients had significant improvement, demonstrating a 69% reduction in total apneas. Five of the six patients reported better-quality sleep and decreased daytime hypersomnolence. Subsequent studies in normal subjects showed that acetazolamide, like other agents known to produce a metabolic acidosis, shifted the hypercapnic ventilatory response to the left 5±0.54 mm Hg. This may be important in mediating the observed decrease in apneas. ( Arch Intern Med 1982;142:1816-1819).