Miracle-dz/UniFAR-FTUs huggingface dataset:
Viability of frozen-thawed mouse embryos is affected by genotype.

Embryos from mice of five different genotypes were evaluated for their ability to survive cryopreservation as measured by post-thaw in vitro development. In Study 1, ovulation was induced with a standardized pregnant mares' serum gonadotropin (PMSG)/human chorionic gonadotropin (hCG) regimen, after which females were mated with males of the same genotype to produce incrossed embryos. Four- to 8-cell embryos were frozen in 1.5 M dimethyl sulfoxide (DMSO) at a rate of 0.5 degrees C/min to -80 degrees C and stored in liquid nitrogen. Following thawing at room temperature, embryos were cultured and development was evaluated 24 h later. The mean (+/- SEM) number of 4- to 8-cell embryos/pregnant female by stock/strain were: N:NIH(S), 6.8 +/- 0.8; N:NIH(S)-B, 5.8 +/- 0.5; N:GP(S), 6.5 +/- 0.6; C57BL/6N, 9.7 +/- 1.0; C3H/HeN MTV-, 9.5 +/- 0.9 (P less than 0.05). Post-thaw in vitro development was related to genetic background; the proportion of embryos culturing after thawing was: N:NIH(S), 49%; N:NIH(S)-B, 61%; N:GP(S), 66%; C57BL/6N, 75%; C3H/HeN MTV-, 56% (P less than 0.05). Study 2 was conducted to evaluate the influence of mating various females to males of a genotype known to have a lower post-thaw embryo survival rate. N:NIH(S)-B, N:GP(S), C57BL/6N, and C3H/HeN MTV- female mice were mated with N:NIH(S) males to produce hybrid embryos. Post-thaw embryo survival was reduced (P less than 0.05) in three of the four hybrid groups. Fresh incrossed and hybrid embryos from each study were cultured for 24 h and yielded culture rates ranging from 95% to 99% (P greater than 0.05) among all groups. (ABSTRACT TRUNCATED AT 250 WORDS)
Power-aware memory management for hybrid main memory

In this paper, we propose the main memory management mechanism of the Operating System (OS) for the hybrid main memory which combines both advantages of DRAM and PRAM (Phase Change RAM). We separate memory pages into hot and cold pages, and dynamically located them to the proper memory region. It was implemented into the Linux OS. We decreased the energy consumption of main memory up to 35% while performance degradation was less than 5%. Moreover, when we decreased the write count for PRAM, life-time of PRAM increased. In addition to these advantages, the system does not need additional hardware.
Identification of current transformers saturation intervals using morphological gradient and morphological decomposition

This paper proposes a novel method to detect the saturation intervals of current transformer (CT) secondary current. The method features the waveform properties of the distorted secondary current, which has abrupt changes where saturation begins and ends. Two algorithms, the improved morphological gradient and the morphological decomposition, are designed to extract the saturation intervals, respectively, and the detection results are combined using the AND logic to give the final detection result. The proposed saturation detection scheme is implemented and tested on a sample power system model built in PSCAD/EMTDC. The simulation results show that the proposed method can accurately detect the onsets and ends of saturations under a variety of operation conditions.
Incorporation d'un greffon aux ischio-jambiers en fonction de la longueur de greffe présente dans les tunnels

Introduction : La reconstruction du LCA a l'aide du semi-tendineux seul, replie en 4 brins (DT4) est une evolution de la technique classique utilisant les 2 ischio jambiers (DIDT). Il n'a jamais ete publie de comparaison de ces deux techniques concernant l'incorporation osseuse de la greffe. DT4 etant plus courte, il y a moins de materiel dans le tunnel osseux. L'objectif principal de cette etude est de comparer l'incorporation du greffon dans le tunnel osseux tibial, a 1 an d'une ligamentoplastie par DIDT et DT4, sur des images IRM. Materiel et Methodes : 62 patients ayant beneficie d'une reconstruction du LCA ont ete inclus prospectivement (31 DT4 et 31 DIDT). La meme technique chirurgicale, les memes moyens de fixation et le meme protocole de reeducation post-operatoire etaient utilises dans les deux groupes. Seule la longueur de greffe presente dans les tunnels etait differente (DT4 est plus courte). L'integration et la ligamentisation ont ete evaluees par mesure IRM a un an de recul. Les parametres suivants etaient analyses. : signal-to-noise quotient (SNQ), elargissement du tunnel tibial, intensite du signal sur l'interface greffon-os echelle de Howell (mesurant le signal de la greffe). Nous avons determine le nombre de sujets necessaires pour demontrer qu'a un an de recul, la difference entre la valeur de SNQ dans les deux techniques n'excedait pas une deviation standard. Avec un risque ? de 2,5 % et un risque s de 10%, nous devions inclure 31 patients dans chaque groupe. Les analyses comparatives ont ete realisees a l'aide de tests t de Student. Resultats : les valeurs moyenne du SNQ etaient de 5.2 ± 4.5 pour le groupe DIDT et 5.9 ± 3.7 pour le groupe DT4 (p>0.05). L'elargissement moyen du tunnel tibial etait de 93.7% +/- 51.7 pour le groupe DIDT contre 80.0 % +/- 42.9 pour le groupe DT4 (p=0.2605). Il n'y avait pas de difference en fonction de l'intensite du signal sur l'interface greffon-os entre les 2 groupes (p= 0.7502) ni en ce qui concerne l'echelle de Howell (p=0.4544). Conclusion : A un an de recul, l'integration et la ligamentisation evaluees par IRM n'etaient pas differentes dans les deux groupes etudies DIDT et DT4. Nous mettons donc en evidence que la longueur de greffe n'influe pas l'integration dans le tunnel.
Conditions of hypertrophy of the seminal vesicles in rats.

a protoplasmic margin free towards the cavity. Mitotic cell divisions characterise the beginning of hypertrophy, they diminish later on. The cavity contains basophilic, homogeneous secretion. Atrophy. Small muscle cells with dark nuclei, low epithelium of cubical cell form, without protoplasmic margin, the nuclei filling the cell bodies almost completely. No mitoses, only sporadic pycnosis of nuclei, imitating cell division. Muscular hypertrophy does occur without epithelial development, while epithelial hypertrophy without a certain muscular development was never observed.
Oribatid mites in soil toxicity testing—the use of Oppia nitens (C.L. Koch) as a new test species

Few soil invertebrate species are available for the toxic assessment of soils from boreal or other northern ecozones, yet these soils cover the majority of Canada's landmass as well as significant portions of Eurasia. Oppia nitens (C.L. Koch) is an herbivorous and fungivorous oribatid mite found in soil throughout Holarctic regions, including Canada. Soil tests using O. nitens were performed using 15 different forest soil types and horizons to investigate test variability in adult survival and reproduction. Adult survival (86.1 ± 1.1%) was consistent across soil types, with a coefficient of variation (CV) of 15%. However, reproduction varied significantly, ranging from 2.9 (±1.1) to 86.2 (±11.7) individuals, with a corresponding CV of 118 and 30%, respectively. Of the soil factors assessed (NH3, NO3, pH, phosphorus [P], organic matter content (OM), carbon:nitrogen (C:N), sand, silt, clay, and sodium adsorption ratio), soil organic matter (OM) explained 68% of the variation observed for reproduction. Increasing the OM using Sphagnum sp. peat moss resulted in optimal reproduction at 7% OM (8% peat content) with the lowest variability (CV of 20%). When assessing the toxicity of a reference chemical, boric acid, the effect of peat amendment reduced lethality to adults with no observable difference on reproduction. The use an age‐synchronized culture reduced the test variability for reproduction relative to the use of unsynchronized cultures. Oppia nitens is a good candidate species for a standardized test design, with adult survival easily assessed in a relatively simple design. A long‐term reproduction test with O. nitens will require the use of a synchronized population and, on occasion, OM amendment when testing soils with low organic matter content. Environ. Toxicol. Chem. 2010;29:971–979. © 2009 SETAC
Diseño y simulación de un método de sintonización de un controlador predictivo basado en modelo mediante un filtro extendido de Kalman para un reactor continuamente agitado

En el presente trabajo se presenta un metodo de sintonizacion de un controlador predictivo (MPC) basado en modelo a traves de un filtro extendido de Kalman. La planta sobre la cual se prueba el algoritmo es un reactor de agitacion continua conocido como CSTR. El desarrollo del trabajo empieza con la obtencion matematica del CSTR a traves de un proceso de identificacion de un sistema lineal de orden reducido. Posteriormente, se formula el controlador predictivo a partir de un sistema en espacio de estados. Finalmente, se implementa el algoritmo del filtro extendido de Kalman para sintonizar las ponderaciones del error y el esfuerzo de control del MPC.
What Does Radiotherapy Do to Endothelial Cells?

It has been presumed that the severe gastrointestinal side effects accompanying radiotherapy in cancer patients result from the radiation-induced death of epithelial stem cells in the intestinal crypts. As Folkman and Camphausen explain in their Perspective, this view may change with the findings of Paris et al., who show that the principal gut cells dying in response to radiation are the endothelial cells of the gut microvasculature. Gut epithelial stem cells die because they depend on microvascular endothelial cells for survival, a situation reminiscent of the dependence of tumor cells on endothelial cell proliferation and the growth of new blood vessels.
Clinical Outcomes during Opioid Titration following Initiation with or Conversion to Remoxy®, an Extended-Release Formulation of Oxycodone

Abstract Intra- and interpatient variability in opioid response usually necessitates opioid therapy titration to optimally balance analgesia and side effects, whether initiating therapy or converting from another opioid. Remoxy® (King Pharmaceuticals, Inc., Bristol, TN, which was acquired by Pfizer Inc in March 2011) is an extended-release formulation of oxycodone designed to maintain its rate-controlling mechanism following physical and chemical manipulation. A recent phase 3 trial, which required dose titration following initiation or conversion to Remoxy, demonstrated the long-term safety and efficacy of Remoxy in relieving moderate to severe chronic pain. In this study, opioid-naïve patients were to be initiated on Remoxy 5 mg twice daily (10 mg total daily oxycodone dose) and opioid-experienced patients were to be converted to Remoxy at a dose equivalent to their previous opioid daily dose, determined from a conversion chart. A post-hoc analysis of study data provided clinically relevant information regarding initiation of or conversion to Remoxy. The intent-to-treat population (N = 823) consisted of 429 opioid-experienced patients (52%) and 394 opioid-naïve patients (48%). A stable Remoxy dose (defined as the first dose administered on 2 consecutive visits, whereby on the first of these visits, further dose titration was deemed unnecessary) was achieved by 325 opioid-experienced patients (76%; mean, 2.2 titration steps), of whom 278 (86%) successfully converted to Remoxy according to the prospectively determined post-hoc definition (≤ 4 titration steps). Of opioid-naïve patients, 300 (76%) reached a stable dose of Remoxy (mean, 2.2 titration steps), 253 (84%) of whom successfully initiated on Remoxy. Pain intensity decreased from baseline to study completion by approximately 35% for both opioid-experienced and opioid-naïve patients and adverse events were similar to those typically reported for opioids, with a higher incidence rate reported during titration (pre-stable dose period). These data provide important clinical information when initiating opioid-naïve patients on or converting opioid-experienced patients to Remoxy.
Heparan sulfate, heparin, and heparinase activity detection on polyacrylamide gel electrophoresis using the fluorochrome tris(2,2′‐bipyridine) ruthenium (II)

The paper shows the ability of the fluorochrome tris(2,2'‐bipyridine) ruthenium (II) (Rubipy) to detect heparan sulfate, heparin, and heparinase activity of M3 murine mammary adenocarcinoma cells as well as bacterial heparinases I, II, and III in native polyacrylamide gel electrophoresis (PAGE). The technique is based on the electrophoretic mobility of high molecular weight heparins and subsequent staining with Rubipy (50 μg/mL). The minimum content of heparin detected by fluorescence in a UV transilluminator was 25—50 ng. The number of Rubipy molecules bound to heparin, determined in relationship to the number of disaccharide units (DU), showed that two to six heparin disaccharide units are bound by each fluorochrome molecule. Scatchard plot analysis showed one Rubipy‐binding site (Kd= (8.56 ± 2.97) × 10−5 M). Heparinase activity was determined by densitometric analysis of the fluorescence intensity of the heparin‐containing band of the gel. While heparinase I (EC 4.2.2.7.) degraded heparin and, to a lower degree, partially N‐desulfated N‐acetylated heparin (N‐des N‐Ac), heparinase II (no EC number) could efficiently degrade heparan sulfate (HS) and partially N‐des N‐Ac heparin. Finally, heparinase III (EC 4.2.2.8.) degraded HS almost exclusively. Only heparin and N‐des N‐Ac heparin were substrates for M3 tumor cell heparinases. We describe a qualitative, sensitive and simple method to detect heparinase activity and determine its substrate specificity using Rubipy fluorescence with heparin and heparan sulfate in multiple biological samples tested in parallel.
Quality of life and its socio‐demographic and psychological determinants after bone marrow transplantation

A host of medical, socio‐demographic, and psychological factors that affect bone marrow transplantation (BMT) patients' quality of life (QOL) have been identified, but due to the methodological diversity of the studies, the findings have been contradictory. The aim of this study was to examine the influence of somatic status, social characteristics, and psychological symptoms on QOL in BMT patients.
"From Snail Mode to Rocket Ship Mode": Adolescents and Young Adults' Experiences of Returning to Work and School After Hematopoietic Cell Transplantation.

PURPOSE Resuming normal activities, such as work and school, is an important dimension of psychosocial recovery in cancer survivorship. Minimal data exist regarding adolescents or young adults' experiences of returning to school or work after cancer. The purpose of this study was to explore the processes of resuming work and school among adolescents and young adults after hematopoietic cell transplantation (HCT). METHODS In-depth interviews were conducted with 18 adolescents and young adults, who were 15-29 years when they underwent HCT and 6-60 months post-transplant at study enrollment. Interview transcripts were systematically analyzed using Grounded Theory methodology. RESULTS Participants described the context in which they attempted to return to work or school, specific challenges they faced, and strategies they developed in these environments. Feeling left behind from their peers and their pre-diagnosis selves, participants described "rushing" back to school and work impulsively, taking on too much too quickly while facing overwhelming physical and cognitive demands. Factors motivating this sense of urgency as well as barriers to successful and sustainable reentry in these settings are also addressed. CONCLUSION Findings are discussed in the context of important opportunities for clinical management, age-appropriate interventions, and implications for future research. A better understanding of psychosocial late effects, specifically related to school and work trajectories after cancer, is critical to survivorship care for adolescent and young adult cancer survivors.
PAPR analysis of superimposed training based MIMO-OFDM systems using an orthogonal affine precoder

Precoder matrices are used in various contexts in the MIMO-OFDM systems. In particular, orthogonal affine precoder (OAP) is used in superimposed training (ST) based MIMO-OFDM system to nullify the data training interference. Precoders are also used to reduce the peak to average power ratio (PAPR) of MIMO-OFDM. In general, the OAP does not reduce the PAPR. In this paper a ZC based OAP is proposed that has lower PAPR compared to random OAPs. We also derive the distribution of PAPR considering ST based MIMO-OFDM systems which uses ZC based OAP and compare with the simulation results.
Increased Accuracy in Image Segmentation Considering the Modular Method Based on Texture Characteristics and Super Pixel

To solve the problem of segmenting an image into homogeneous regions with large area, this paper proposes an efficient algorithm that is based optimization base on modularity and super pixel method. Due to the fact that a very small areas of the image before segmentation, the proposed algorithm automatically merged with neighboring small areas and to make larger modules. When the modularity pictures after the merger to reach its maximum stop, leading to the production of segmentation algorithms are final. To keep repetitive patterns in a homogeneous area, a feature based on its histogram modularity with features like color and eventually identified two areas by creating a similarity matrix, it is suggested. So that the problem of segmentation and complexity of the problem to some extent eliminate in a way that due to the combined areas can be achieved for repetitive patterns. Simulation results show that the algorithm has good accuracy.
Sleep and quality of life in the Austrian population

Purpose– To compare the self‐reported estimation of sleep quality evaluated by the Pittsburgh Sleep Quality Index (PSQI) and life quality assessed by the Quality of Life Index (QLI). Background– The PSQI comprised 19 questions and assessed a wide variety of factors relating to sleep quality. The QLI consisted of 10 items for self assessment of different dimensions of life quality. Subjects– A representative Austrian sample (n=1049) aged above 15 years. Procedure– Interviews in the homes of the participants. Results– 32.1% could be classified as poor sleepers (37% females, 26.5% males). Sleep quality decreased with increasing age, especially in women. Overall quality of life was highest in younger (15–29 years) and lowest in elderly subjects (over 50 years). Life quality decreased with increasing age. Between subjective sleep quality and quality of life a moderate, significant correlation was found (r2=0.6721). Conclusions– Complaints about a bad quality of sleep could be used as a screening method in the exploration of patients' quality of life (QoL).
SNRIs: mechanism of action and clinical features

Specific serotonin and norepinephrine reuptake inhibitors are a relatively recent class of antidepressants which have specificities making them a therapeutic choice. They are characterized by a mixed action on both major neuroamines of depression: norepinephrine and serotonin. The double polarity of the reuptake inhibition of serotonin and norepinephrine ensures a profile of effectiveness comparable to tricyclic antidepressants and higher than selective serotonin reuptake inhibitors, especially in severe depression. The absence of affinity for muscarinic, histaminic and α1-adrenergic receptors and the absence of action on monoamine oxidase limits their adverse effects and allows them to be better tolerated than tricyclic antidepressants and similar to selective serotonin reuptake inhibitors. Currently, two drugs of this class are available, milnacipran and venlafaxine, but several more are in development. They are active on depressive symptoms, as well as on certain comorbid symptoms (anxiety, sleep disorders) frequently associated with depression. Serotonin and norepinephrine reuptake inhibitors allow an improved rate of response and a significant rate of remission, decreasing the risk of relapse and recurrence in the medium and long term. Due to their good tolerance, they can also be prescribed for long-term treatment and in high doses in refractory depression or with strong potential of relapse. For all these reasons, one can reasonably conclude that serotonin and norepinephrine reuptake inhibitors represent the therapeutic of choice in depression and that their prescription is likely to strongly increase in the years to come.
Preoperative Carbohydrate Antigen 19-9 is Most Predictive of Malignancy in Older Jaundiced Patients Undergoing Pancreatic Resection

Objectives: Given the increased detection of occult pancreatic neoplasms with modern imaging modalities, it is often difficult to determine the risk of malignancy before curative pancreatectomy. We reviewed patients who underwent pancreatectomy to determine factors predictive of malignancy with particular attention to the serum marker carbohydrate antigen 19-9 (CA19-9). Methods: One hundred eighteen patients underwent radical pancreatectomy for malignant (n = 59) or benign (n = 59) pancreatic lesions. Demographic data, preoperative CA19-9 levels (normal, <37 U/mL), and follow-up were obtained from patient charts. Logistic regression analysis was used to determine univariate and multivariate predictors of malignancy. Results: Significant multivariate predictors of malignancy were increased CA19-9, age older than 50 years, and preoperative jaundice. The sensitivity and specificity of increased preoperative CA19-9 alone were 71% and 83%, respectively. The combination of age older than 50 years and jaundice was a more accurate predictor than CA19-9 (sensitivity, 76%; specificity, 92%). Increased CA19-9 was highly specific (97%) for malignancy in older jaundiced patients or when the preoperative level was greater than 150 U/mL. Conclusions: Age and preoperative jaundice are more predictive of malignancy than CA19-9 alone unless levels are greater than 150 U/mL. Preoperative CA19-9 levels should be interpreted within the context of these other clinical factors.
In vitro susceptibilities and beta-lactamase production of 53 clinical isolates of Branhamella catarrhalis

We tested 53 clinical isolates of Branhamella catarrhalis recovered from patients with respiratory symptoms to determine the susceptibility of the isolates to 25 antimicrobial agents, including the newer beta-lactam antibiotics. Of the 53 strains, 46 (86.7%) were beta-lactamase producers. All the strains were susceptible to the majority of the new penicillins and cephalosporins. The combinations of amoxacillin-clavulanic acid and ticarcillin-clavulanic acid were also very active against the beta-lactamase-producing strains.