Miracle-dz/UniFAR-FTUs huggingface dataset:
Synergistic effect of all-trans-retinoic acid and arsenic trioxide on growth inhibition and apoptosis in human hepatoma, breast cancer, and lung cancer cells in vitro.

AIM To investigate the effect of all-trans-retinoic acid (ATRA) on arsenic trioxide (As(2)O(3))-induced apoptosis of human hepatoma, breast cancer, and lung cancer cells in an attempt to find a better combination therapy for solid tumors. METHODS Human hepatoma cell lines HepG2, Hep3B, human breast cancer cell line MCF-7, and human lung adenocarcinoma cell line AGZY-83-a were treated with As(2)O(3) together with ATRA. Cell survival fraction was determined by MTT assay, cell viability and apoptosis were measured by annexin V-fluorescein isothiocyanate (FITC) and PI staining, and intracellular glutathione (GSH) and glutathione-S-transferase (GST) activities were determined using commercial kits. RESULTS Cytotoxicity of ATRA was low. ATRA (0.1, 1, and 10 micromol/L) could synergistically potentiate As(2)O(3) to exert a dose-dependent inhibition of growth and to induce apoptosis in each of the cell lines. HepG2 and Hep3B with low intracellular GSH or GST activities were remarkably sensitive to As(2)O(3) or As(2)O(3)+ATRA, while AGZY-83-a with higher GSH or GST activities was less sensitive to As(2)O(3) or As(2)O(3)+ATRA. Treatment with 2 micromol/L As(2)O(3) for 72 h significantly decreased intracellular GSH and GST levels in each of the cell lines, and 1 micromol/L ATRA alone reduced minimal intracellular GSH and GST levels. ATRA potentiated the effect of As(2)O(3) on intracellular GSH levels, but intracellular GST levels were not significantly affected by the combination of As(2)O(3) and ATRA for 72 h as compared to As(2)O(3) alone. CONCLUSION ATRA can strongly potentiate As(2)O(3)-induced growth-inhibition and apoptosis in each of the cell lines, and two drugs can produce a significant synergic effect. The sensitivity to As(2)O(3) or As(2)O(3)+ATRA is inversely proportional to intracellular GSH or GST levels in each of the cell lines. The GSH redox system may be the possible mechanism by which ATRA synergistically potentiates As(2)O(3) to exert a dose-dependent inhibition of growth and to induce apoptosis.
Tuberculosis Epidemic Among Hospital Personnel

Abstract Six employees of the emergency department at Parkland Memorial Hospital developed active tuberculosis in 1983-1984. Five of the cases occurred four to 12 months after exposure to the index case, a patient with severe cavitary tuberculosis seen in the emergency department in April 1983. One resident physician developed cavitary disease after exposure to this patient. An additional employee case may have resulted from transmission from one of the initial employee cases. One immunocompromised patient may have acquired tuberculosis as a result of exposure to the index case. In addition, the tuberculin skin tests of at least 47 employees exposed to the index case converted from negative to positive. Of 112 previously tuberculin-negative emergency department employees who were tested in October 1983, 16 developed positive skin tests, including the 5 employees with active disease. Fifteen of these new positives had worked on April 7, 1983, while the index case was in the emergency department (x2 = 20.6, P <0.00l). Factors related to the genesis of the epidemic included the disease characteristics in the index case and the recirculation of air in the emergency department. This investigation indicates that city-county hospital emergency department employees should be screened at least twice a year for evidence of tuberculosis and that the employee health services of such hospitals should regard the surveillance of tuberculous infection among personnel at a high-priority level.
THE "EVENING SUN": THIRD AGE AND HEALTH PSYCHOLOGY

AGEING SCIENCE AND PERSONALITY EVOLUTION When talking about the third age, we can either use a chronological criterion (from 60 to 75 years) or a functional criterion (what one does and what one is able to do). In particular, this second meaning is a subject of great interest for the most recent version of the “ageing science”. To be more exact: the “science of the advancing age”. In fact, today the potentialities available for people who are more mature in years, are countless to the point that they can become a source of remarkable positive change. This moves the traditional boundaries of geriatrics/gerontology (in the past almost exclusively the dominion of the bio-medical sciences with a strong pathological-clinical perspective) towards softer areas, where psychology particularly the one dedicated to health and wellbeing is able to make a positive contribution to a fulfilling passage through this “phase” of life. Therefore, this period can be lived as a further “evolution”, consequently as a cognitive-emotional enrichment, as well as a preparation for the so-called deferred “old age”. Finally, the individual, the person has even more new instruments available to assist them in this evolution.
Ijee Soapbox: Cultural Amnesia in the Ecological Sciences

With the explosion of knowledge all around us, it is becoming increasingly difficult for any of us in science to keep up with the latest ideas and findings of our disciplines. Maybe more importantly, the incessant pressure of dealing with the “new” at times threatens to submerge any appreciation we may have of the broader historical intellectual context from which current concerns in our disciplines emerge. This issue is aggravated by the fact that intellectual history is seldom a straight run across a smooth and obvious landscape. Rather, it is more like a braided tangle of trails, with many intersecting and merging paths and byways. I was reminded of this dilemma of the modern condition recently when preparing a lecture for an advanced course in Fribourg, Switzerland, focused on the theme of metacommunities. The organizer, Professor Louis bersier, asked me to kick off the course with a lecture on the historical context of metacommunity ecology. In putting this lecture together, I came across some little-known quotes from one of the founding figures of ecology, Charles Elton, which resonated with the concerns of this course, more broadly with the increasing emphasis on spatial aspects of ecology (Levin, 1993), and to an uncanny extent, some themes in my own work. So as not to lose some readers, I should start with a few definitions. If a “community” is “a collection of species found in a particular place” (morin, 1999), a “metacommunity” is “a set of local communities linked by dispersal of multiple potentially interacting species” (Wilson, 1992). The metacommunity perspective is increasingly important in many different theoretical approaches in ecology, from neutral models (Hubbell, 2001) to nicheand patch-centered perspectives on community organization (Leibold et al.,
Impact of Protein and Certain Amino Acids Levels on Performance of Growing Japanese Quails

A 2×2×2 factorial design experiment was carried out with two levels of protein (20 and 22%), two levels of lysine (1.05 and 1.15%) and two levels of total sulfur amino acids (TSAA) (0.8 and 0.9%) to investigate their effect on growth performance and carcass characteristics of growing Japanese quail. A total number of 408 unsexed one week old Japanese quail chicks were randomly distributed into eight treatment groups of 51 chicks each with three replicates (each of 17 chicks). Live body weight at 21 and 42 days and feed intake during 21-42 days of age was significantly affected (P 0.05) influences carcass traits. The results of economical efficiency indicated that the best economical efficiency was recorded by quail chicks fed 20% crude protein with 1.05% lysine and 0.8% TSAA up to 42 days of age.
Risks and benefits of diagnostic angiography after aneurysm surgery: a retrospective analysis of 597 studies.

INTRODUCTION Cerebral angiography performed after aneurysm surgery can identify causes of morbidity and mortality that may be corrected. The risks and benefits of angiography that is performed after aneurysm surgery, however, have not been clearly defined. We therefore reviewed our experience with postoperative angiography to determine its dangers and benefits. METHODS During 10 years, 543 consecutive patients received treatment for cerebral aneurysms. A retrospective analysis of 597 diagnostic angiograms obtained after aneurysm surgery for 494 of these patients was performed. RESULTS Catheter-induced vessel spasm and dissection, occurring most frequently in the internal carotid artery, were observed in seven (1.2%) and six (1%) studies, respectively. No angiography-associated strokes were identified. No association between age, smoking, hypertension, blood pressure, atherosclerosis, or severe vasospasm and angiographic complications was observed. Aneurysm remnants were identified in 36 (5.7%) of the 637 aneurysms that were surgically treated. Atherosclerosis (P < 0.01) or multiple clip applications (P < 0.01) were significantly associated with aneurysm remnants. Angiographic vessel occlusion was observed in 28 (5.7%) patients and resulted in stroke in 14 of these patients. Vessel occlusion was significantly associated with increasing aneurysm size (P < 0.001), atherosclerosis (P < 0.001), temporary clips (P < 0.001), multiple clips (P=0.03), multiple clip applications (P=0.001), and a new postoperative neurological deficit (P=0.002). Severe vasospasm and newly identified aneurysms were observed in 51 and 16 patients, respectively. CONCLUSION Angiography after aneurysm surgery is safe and can be routinely performed. Angiography after aneurysm surgery should be particularly considered for patients with large aneurysms or cerebrovascular atherosclerosis and for those who develop new postoperative neurological deficits.
Quality characteristics of wheat flour dough and bread containing grape pomace flour

Wheat bread was enriched with 6%, 10% and 15% dried and milled grape pomace flour from two grape cultivars: ‘Merlot’ and ‘Zelen’. Rheological, textural, sensory and antioxidant properties of the enriched dough and bread were evaluated, and compared to control samples. Grape cultivar had significant impact on the rheological characteristics of the dough, and on the sensory and antioxidant properties of the final bread. Development time and dough stability were longer when ‘Merlot’ grape pomace flour was added compared to ‘Zelen’ grape pomace flour and the control. Grape pomace flour addition affected bread volume, firmness, crumb and crust colour, and odour and taste intensity. Moreover, grape pomace flour addition resulted in a stickier and less springy crumb texture, and some negative sensorial properties, such as increased intensity of aftertaste and sand feeling in the mouth. The phenolic content and antioxidant activity of bread were positively correlated with grape pomace flour addition (r = 0.987, p = 0.01 and r = 0.941, p = 0.01 between phenolic content and ferric reducing antioxidant power and phenolic content and 2,2-diphenyl-1-picrylhydrazyl, respectively). The highest total phenolic contents were 5.92 mg gallic acid equivalents (GAE)/g dw for ‘Merlot’ and 3.65 mg gallic acid equivalents /g dw for ‘Zelen’, which were seen for the bread prepared with the highest grape pomace flour addition (15%). The highest antioxidant activity determined by the 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power assays were seen for the bread prepared with the highest ‘Merlot’ grape pomace flour addition (15%). Dough characteristic and sensory profile are strongly influenced by cultivar of grape pomace flour. Based on results of sensory profiling, the variety ‘Zelen’ is suggested for use.
VITAMIN A DEFICIENCY AMONG SCHOOL CHILDREN OF BAREILLY: CRUCIAL ROLE OF NUTRITION EDUCATION

Objectives: To find out the prevalence of VAD among urban school children of District Bareilly, to identify the associated biosocial factors and to suggest the suitable measures to prevent xerophthalmia among them. Methods: Six month cross sectional study was conducted among school going children in 2 purposively selected schools in an urban area of Bareilly District. A structured proforma was used to collect the information. Chi- square test was used to analyze data. Results: Of the 800 children examined, the overall prevalence of VAD was found to be 6.37%. The prevalence of VAD was highest in 11-12 years of age group children and lowest in the 3-5 years age group (P-value >.05). The prevalence of VAD was slightly higher among boys as compared to girls (P-value >.05). The prevalence of VAD was significantly higher among the children belonging to lower socioeconomic class as compared to those belonging to upper and middle socioeconomic class (P-value >.05). Nearly 48.5% of children were found to be underweight while 12.25% were overweight. Nearly a quarter of children were found to be anemic. Conclusion: Nutrition education regarding regular intake of plant foods rich in carotene such as green leafy vegetables, yellow fruits, carrots and animal foods containing retinol like fish liver oil, fish, liver, egg, meat, milk, butter, cheese, and use of fortified food like vanaspati, margarine, dried skimmed milk should be strengthened.
cDNA sequence coding for a translationally controlled human tumor protein.

The sequence presented was obtained by screening a cDNA library constructed in lambda gtlO from human mammary carcinoma with probes derived from cDNA of the translationally controlled, growth-related mouse tumor protein p23 (1,2). It has 86% similarity to the mouse cDNA sequence and encodes a protein with 96% similarity to the mouse tumor protein. The 3-primed noncoding region of the appropriate mRNA has three putative translation inhibitory elements (3), which are underlined.
Radiographic Analysis of Wedge Allograft Correction of Angular Malalignment in Ankle Fusion

Background: Patients undergoing ankle arthrodesis often have coronal or sagittal plane malalignment. Correction of this deformity can be technically challenging. This retrospective review examines the use of an augmented interposition wedge allograft for deformity correction in ankle arthrodesis. Materials and Methods: Nineteen patients underwent open ankle arthrodesis with interposition allograft at our institution since 2003. Sixteen patients had isolated ankle fusions and three patients had ankle fusions as part of a tibiotalocalcaneal fusion. A wedge of frozen tricortical iliac crest or femoral head allograft was cut to appropriate size and shape to correct angular deformity with an average maximum graft width of 9.5 mm. Fixation of the arthrodesis was with either a cannulated screw and plate construct or a lateral blade plate. Radiographs were reviewed to assess preoperative, initial postoperative and final alignment at the time of solid fusion. Fusion was assessed on plain radiographs by visualization of bridging bony trabeculae. Results: Seventeen of 19 patients (89%) obtained fusion at an average of 14.9 wks. Eleven ankles had preoperative tibiotalar valgus deformity with an average coronal alignment of 98.8 degrees and sagittal alignment of 110.5 degrees. Final coronal alignment was 90.9 degrees and sagittal alignment was 107.7 degrees. Eight ankles had varus deformity with an average coronal alignment of 77.4 degrees and sagittal alignment of 101.9 degrees. Final coronal alignment was 89.4 degrees and sagittal alignment was 107.4 degrees. Conclusion: The tibiotalar joint fusion rate in this series compares favorably to historically published data for standard ankle fusion. Interposition allograft was an effective method for deformity correction in difficult ankle arthrodeses. Level of Evidence: IV, Retrospective Case Series
Comorbidity and functional status are independent in older cancer patients.

PURPOSE Comorbidity is a frequent and often therapeutically limiting problem in older cancer patients. However, to date, there is no standard measure of the comorbidity burden available for these patients. We tested the performance of two comorbidity scales and their relationship with functional status. PATIENTS AND METHODS The Cumulative Illness Rating Scale-Geriatric (CIRS-G) was compared with the Charlson scale in 203 patients who received a comprehensive geriatric assessment (CGA) in our Senior Adult Oncology Program (SAOP). Study end points were variability, reliability, correlation with Eastern Cooperative Oncology Group (ECOG) performance status (PS), Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL). The relative weight of comorbidity versus tumor stage in the correlations with functional status was assessed. RESULTS Median age was 75 years (range, 63 to 91). Sixty-four percent of patients scored 0 on the Charlson scale versus 6% on the CIRS-G. The correlation between the Charlson and CIRS-G was fair (p = 0.25 to 0.39). CIRS-G grade 3/4 had a fair correlation with ADL (p = 0.27). Otherwise, there was low or no correlation between comorbidity and functional status across the measures. Tumor stage was not correlated with functional status either. Correlation of ECOG PS with ADL (p = 0.51)c and IADL (p = 0.61) was moderate. Interrater and test-retest correlations were good or very good for both the Charlson and CIRS-G. CONCLUSION Comorbidity needs to be assessed independently from functional status. Both the Charlson and CIRS-G scales are reliable tools for use in trials of older cancer patients. Both can be tested in further studies as predictors of outcomes such as toxicity of treatment, changes in functional status, or survival.
Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects.

It is demonstrated that the maximum tubular reabsorption capacity for glucose (Tmo) is significantly increased in young patients with diabetes of short duration. (Mean value for diabetics: 419±50 mg/min (n = 10); mean value for normals: 352±64 mg/min (n = 9). GFR is also significantly increased in diabetics. For the whole material there was a clear positive correlation between GFR and Tmc. In the normal subjects GFR was constant during the high glucose level, whereas RPF increased. In the diabetics, RPF was constant but GFR decreased consistently about 9 per cent. In both diabetics and normals there was a decrease in urinary potassium excretion and an increase in urinary sodium excretion during glucose infusion.
Interactions between Data Mining and Natural Language Processing

Extractive summarization of text documents usually consists of ranking the document sentences and extracting the top-ranked sentences subject to the summary length constraints. In this paper, we explore the contribution of various supervised learning algorithms to the sentence ranking task. For this purpose, we introduce a novel sentence ranking methodology based on the similarity score between a candidate sentence and benchmark summaries. Our experiments are performed on three benchmark summarization corpora: DUC-2002, DUC2007 and MultiLing-2013. The popular linear regression model achieved the best results in all evaluated datasets. Additionally, the linear regression model, which included POS (Part-of-Speech)-based features, outperformed the one with statistical features only.
Are Commercially Available Essential Oils from Australian Native Plants Repellent to Mosquitoes?

Abstract While the use of topical insect repellents, particularly those containing synthetic active ingredients such as deet (N,N-diethyl-3-methylbenzamide), are a mainstay in personal protection strategies emphasized in public health messages, there is a growing demand in the community for alternative repellents, particularly those of botanical origin and thus deemed to be “natural. ” This study evaluated the repellency of essential oils from 11 Australian native plants in 5% v/v formulations against Aedes aegypti, Culex quinquefasciatus, and Culex annulirostris under laboratory conditions. A blend of the top 3 performing oils was then compared with deet and a commercially available botanical insect repellent. All essential oils provided at least some protection against the 3 mosquito species, with the longest protection time (110 min) afforded by Prostanthera melissifolia against Cx. quinquefasciatus. Mean protection times against Ae. aegypti were substantially lower than those for the Culex spp. tested. Deet provided significantly longer protection against Ae. aegypti than both the 5% v/v blend of Leptospermum petersonii, Prostanthera melissifolia, and Melaleuca alternifolia (the 3 most effective oils) and the commercial botanical repellent. The results of this study indicate that these essential oils from Australian native plants offer limited protection against biting mosquitoes and that a blend of essential oils holds may offer commercial potential as a short-period repellent or under conditions of low mosquito abundance. However, it is important that public health messages continue to emphasize the greater effectiveness of deet-based repellents in areas with risks of mosquito-borne disease.
The Misuse and Diversion of Prescribed ADHD Medications by College Students

Objective: This study assesses the misuse and diversion of prescribed attention-deficit/hyperactivity disorder (ADHD) medications. Method: One hundred fifteen students, attending two universities, with prescriptions for ADHD medications completed a Web survey in spring 2007. Results: Eighty-nine of 115 students (69%) used their ADHD medications as prescribed, whereas 36 (31%) had misused during college by taking larger or more frequent doses than prescribed or by using someone else’s medication. Nine students (8%) reported intranasal use during the previous 6 months, and 30 (26%) had diverted medications to peers. Misuse was associated with impulsivity and with other substance use. Enhancing the ability to study outside of class was students’ primary motive for misuse, but nonacademic reasons were also reported. Students who misused ADHD medications generally felt that doing so was helpful. Conclusions: Although most students use their ADHD medication as prescribed, misuse and diversion is not uncommon. Because enhancing academic performance was the primary motive for misuse, the results raise questions about whether undergraduates with ADHD perceive their treatment as adequate and the extent to which physicians and students communicate about issues related to medication adjustments. (J. of Att. Dis. 2009; 13(2) 144-153)
The Influence of Exogenous Tissue Factor on the Regulators of Proliferation and Apoptosis in Endothelial Cells

Background: The exposure of tissue factor (TF) at the site of injury or trauma is a rapid process that leads to the initiation of blood coagulation as well as homeostatic processes giving rise to vascular repair. Aims and Methods: By exposing human endothelial cells to combinations of exogenous TF and factor VIIa (FVIIa) in serum-free medium, the influence of TF concentrations on cellular proliferation and apoptosis was investigated. Results: Lower concentrations of TF resulted in increased cellular proliferation as well as upregulation of cyclin D1, downregulation of p21 and p27 and induction of tube formation in vitro. Conversely, incubation with higher concentrations of TF resulted in the activation of caspase-3, expression of p53 and Bax, translocation of p53 into the nucleus and induction of DNA fragmentation. Incubation of the cells with TF/FVIIa led to a lower proliferation rate with additional upregulation in p27. Conclusions: TF seems to have a bifunctional role in determining the fate of endothelial cells, depending on the concentration and the interactions of this protein. The release of TF in the locality of the injured tissue makes this protein an ideal factor for ascertaining the level of injury and determining the fate of the cells.