Miracle-dz/UniFAR-FTUs huggingface dataset:
Flow diverter stent treatment for ruptured basilar trunk perforator aneurysms

Objective Basilar trunk perforator (BTP) aneurysms are rare. Treatment options traditionally considered for these uncommon lesions have included direct surgery, endovascular therapy, or conservative management. Flow diverters represent a newer therapeutic option for BTP aneurysms but pitfalls and complications are unknown. We describe three patients with BTP aneurysms treated with flow diverter stents. Methods All three patients had ruptured BTP aneurysms and, after loading doses of dual antiplatelet agents, underwent treatment with a flow diverter alone (two patients) or in combination with an intracranial stent (one patient). Results Complications directly (two thromboembolic events) or indirectly (one hemorrhage at the external ventricular drain site, probably facilitated by the dual antiplatelet therapy) occurred in all three patients and resulted in permanent morbidity in one case. Imaging follow-up confirmed obliteration in all three patients, and no episodes of rebleeding from the aneurysms were observed at follow-up. Conclusions Flow diverters are effective in obliterating BTP aneurysms. However, given the challenges and complications encountered, especially in patients with ruptured lesions, their use must be carefully weighed against other available therapeutic modalities, including observation.
Automatic Question Generation Using Wikipedia

: In Our system there is automatic question generation used for academic work. Where key phrases are extracted. extracted key phrases are match with Wikipedia and classified: Researcher, Technologies, Systems, Methods, and Other. With the help of Wikipedia article system generates conceptual graph structure and according to that questions are generated. To evaluate the quality of the computer generated questions, we conducted a version of the Bystander Turing test, which involved 20 research students who had written literature reviews for an IT methods course. The pedagogical values of generated questions were evaluated using a semi-automated process. The results indicate that the students had difficulty distinguishing between computer generated and supervisor-generated questions. Computer-generated questions were also rated as being as pedagogically useful as supervisor-generated questions, and more useful than generic questions. The findings also suggest that the computer-generated questions were more useful for the first-year students than for second or third-year students.
Investigational cytokine-targeted therapies for ulcerative colitis

Introduction: Up to one-third of patients with ulcerative colitis (UC) do not respond to standard medications, including mesalamine, steroids and thiopurines. The recognition that UC-related pathological process is the result of an altered balance between inflammatory and counter-regulatory signals, mostly mediated by cytokines, has led to the development of novel compounds, which are now ready to move into clinical practice. This article summarizes the recent data on the development and use of compounds either inhibiting inflammatory cytokines or enhancing the activity of counter-regulatory cytokines in patients with UC and murine models of UC. Areas covered: A PubMed search was performed using the following keywords: ‘ulcerative colitis', ‘therapy', ‘treatment' and ‘cytokine'. In addition, ongoing clinical trials were checked and compounds were searched on the website of pharmaceutical companies. Expert opinion: Several investigational cytokine-based therapies have provided promising results in attenuating clinical activity in patients with UC and mice with experimental colitis. However, clinical and immunological heterogeneity of UC patients, therapy-related side effects and redundant biological functions of cytokines represent potential pitfalls and should be considered in optimizing therapeutic strategies.
Medication errors, handoff processes and information quality: A community hospital case study

Purpose – The purpose of this paper is to examine how clinical handoffs affect clinical information quality (IQ) and medication administration quality.Design/methodology/approach – A case study was conducted in a US hospital. The authors applied a business process management (BPM) perspective to analyze an end‐to‐end medication administration process and related handoffs, and accounting control theory (ACT) to examine the impact of handoffs on IQ and medication errors.Findings – The study reveals how handoffs can lead to medication errors (by passing information that is not complete, accurate, timely or valid) and can help reduce errors (by preventing, detecting and correcting information quality flaws or prior clinical mistakes). Research limitations/implications – The paper reports on one case study on one hospital unit. Future studies can investigate the impact of clinical IQ on patient safety across the multitude of health information technologies (e.g. computerized provider order entry (CPOE), electro.
Two‐Dimensional Dielectric Nanosheets: Novel Nanoelectronics From Nanocrystal Building Blocks

Two‐dimensional (2D) nanosheets, which possess atomic or molecular thickness and infinite planar lengths, are regarded as the thinnest functional nanomaterials. The recent development of methods for manipulating graphene (carbon nanosheet) has provided new possibilities and applications for 2D systems; many amazing functionalities such as high electron mobility and quantum Hall effects have been discovered. However, graphene is a conductor, and electronic technology also requires insulators, which are essential for many devices such as memories, capacitors, and gate dielectrics. Along with graphene, inorganic nanosheets have thus increasingly attracted fundamental research interest because they have the potential to be used as dielectric alternatives in next‐generation nanoelectronics. Here, we review the progress made in the properties of dielectric nanosheets, highlighting emerging functionalities in electronic applications. We also present a perspective on the advantages offered by this class of materials for future nanoelectronics.
HybridTagger : un étiqueteur hybride pour le Français

Dans cet article, nous presentons une approche hybride de l'etiquetage morphosyntaxique. Nous combinons les approches de desambiguisation symbolique et statistique dans un meme processus d'etiquetage. De plus, ce processus utilise massivement des ressources lexicales externes qui nous permettent d'obtenir un etiquetage performant des mots inconnus.
Protection of immunocompromised mice against lethal infection with Pseudomonas aeruginosa by active or passive immunization with recombinant P. aeruginosa outer membrane protein F and outer membrane protein I fusion proteins

Recombinant outer membrane proteins (Oprs) of Pseudomonas aeruginosa were expressed in Escherichia coli as glutathione S-transferase (GST)-linked fusion proteins. GST-linked Oprs F and I (GST-OprF190-350 [GST linked to OprF spanning amino acids 190 to 350] and GST-OprI21-83, respectively) and recombinant hybrid Oprs (GST-OprF190-342-OprI21-83 and GST-OprI21-83-OprF190-350) were isolated and tested for their efficacy as vaccines in immunodeficient mice. GST-OprF-OprI protected the mice against a 975-fold 50% lethal dose of P. aeruginosa. Expression of GST-unfused OprF-OprI failed in E. coli, although this hybrid protein has been expressed without a fusion part in Saccharomyces cerevisiae and used for immunizing rabbits. The immune rabbit sera protected severe combined deficient (SCID) mice against a 1,000-fold 50% lethal dose of P. aeruginosa. Evidence is provided to show that the most C-terminal part of OprF (i.e., amino acids 332 to 350) carries an important protective epitope. Opr-based hybrid proteins may have implications for a clinical vaccine against P. aeruginosa.
Are Patients in Favour of General Health Screening?

In order to determine whether patients are in favour of general health screening, two sex-matched groups of patients of similar age from a general practice were studied; a group of 315 consecutive patients who attended the practice and 93 individuals who had not attended the practice for at least 12 months were studied. Individuals in both groups were provided with a short, anonymous questionnaire about their desire for general health screening. Although roughly equal proportions of the attenders (93%) and non-attenders (88%) indicated that general health screening was a ‘good idea’, a significantly greater proportion of the attenders (83%) indicated that they would make an appointment and attend the practice for health screening compared to the non-attenders (66%) (P < 0.002). Similarly, a significantly greater proportion of the attenders (33%) indicated that they would seek general health screening, even if not contacted by their doctor, when compared with the non-attenders (16%) (P < 0.001). Thus patients in this study were greatly in favour of general health screening. However, patients who attended the general practice infrequently may represent a population who are relatively resistant to health screening.
A battery cell balancing control scheme with minimum charge transfer

According to the analysis of the imbalance in series-connected lithium-ion batteries, the state-of-health (SOH) and the energy utilization is mainly influenced when the cells are fully charged or discharged. Therefore, balancing is not necessarily required all the time. In addition, the energy loss of the balancing system is closely related to the charge transfer among different cells. This paper proposes an active balancing control scheme that utilizes the required charge of each cell as the balancing reference. With the scheme, the charge transfer during the balancing process can be minimized so that the energy loss can be reduced and the balance can be achieved when the cells are fully charged or discharged, which not only improves the battery lifetime but also increases the available energy. The proposed control is applied in a balancing system based on the direct cell-to-cell architecture and bi-directional buck/boost converter. Experimental results have verified the effectiveness of the proposed control.
[Levels of glycosylated hemoglobin and the difference in the cost of health care for diabetic patients: an econometric study].

BACKGROUND Complications increase treatment costs of diabetes mellitus (DM). An adequate metabolic control of the disease could reduce these costs. AIM To evaluate the costs of medical care for a cohort of patients with DM, according to their degree of metabolic compensation. MATERIAL AND METHODS All diabetic patients attended in a regional hospital from 2005 to 2010 were analyzed. A correlational study between costs of individual healthcare and levels of glycosylated hemoglobin (HbA1c), was performed in a series of annual cross-sectional measurements. RESULTS The study comprised 1,644 diabetic patients. During the study period the average cost of healthcare per patient increased from $878,000 to more than $1,000,000 Chilean pesos (CLP) during the study period. The percentage of patients with HbA1c levels below 7.0% varied between 43.0% and 54.9%. Costs for patients with HbA1c levels between 7 and 8.9% were 1.3 to 1.5 times greater. For the group of patients with HbA1c levels between 9 and 10.9% the costs increased 1.4 to 1.6 times. For patients with HbA1c levels greater than 11.0%, healthcare costs doubled. CONCLUSIONS Healthcare expenditure varied according to metabolic control, which is consistent with international findings. This study was limited by its selected population, incomplete information on health expenditures, and the inclusion of only direct costs to the health system. If all patients would achieve metabolic compensation, the yearly savings would be CLP $308,000,000 (or USD $657,000).
Occurrence of mucoid M-18 Streptococcus pyogenes in a central Ohio pediatric population

During a 1-year period from October 1986 through September 1987, we recovered 116 mucoid, hemolytic Streptococcus pyogenes isolates from clinical specimens collected from patients seen at our pediatric institution. A total of 102 isolates were from throat cultures (101 for pharyngitis, 1 for acute rheumatic fever), 13 were from other superficial body sites, and 1 was from pleural fluid. All of 40 mucoid isolates tested to date were determined to be M-type 18 strains. A direct latex agglutination test for group A carbohydrate antigen in throat swab specimens was equally sensitive in detecting M-18 mucoid and nonmucoid strains (45 of 77 [58%] and 795 of 1,186 [67%], respectively; not significant, P greater than 0.05). Antimicrobial susceptibility tests performed with 40 mucoid and 40 nonmucoid isolates against penicillin and nine other antimicrobial agents showed all strains to be susceptible, with no difference in MICs. All isolates tested were also considered fully susceptible to the bactericidal activity of penicillin. Further studies are needed to establish the relative virulence of M-18 strains and their possible association with the resurgence of acute rheumatic fever in central Ohio and other areas of the United States.
A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood

Early origins of adult disease may be defined as adversity or challenges during early life that alter physiological responses and prime the organism to chronic disease in adult life. Adverse childhood experiences or early life stress (ELS) may be considered a silent independent risk factor capable of predicting future cardiovascular disease risk. Maternal separation (MatSep) provides a suitable model to elucidate the underlying molecular mechanisms by which ELS increases the risk to develop cardiovascular disease in adulthood. The aim of this review is to describe the links between behavioural stress early in life and chronic cardiovascular disease risk in adulthood. We will discuss the following: (i) adult cardiovascular outcomes in humans subjected to ELS, (ii) MatSep as an animal model of ELS as well as the limitations and advantages of this model in rodents and (iii) possible ELS‐induced mechanisms that predispose individuals to greater cardiovascular risk. Overall, exposure to a behavioural stressor early in life sensitizes the response to a second stressor later in life, thus unmasking an exaggerated cardiovascular dysfunction that may influence quality of life and life expectancy in adulthood.
3-Acetyl-4''-isovaleryl tylosin for prevention of swine dysentery.

The 21 field isolates of Treponema hyodysenteriae which were tested were sensitive to 3-acetyl-4''-isovaleryl tylosin (AIV); the minimal inhibitory concentration was 0.25 to 16 micrograms/ml. 3-Acetyl-4''-isovaleryl tylosin administered prophylactically to pigs at concentrations of 5 to 100 mg/kg of feed and tylosin at 110 mg/kg of feed for 28 or 31 days prevented swine dysentery induced by tylosin-sensitive T hyodysenteriae strain SQ2; 15 nonmedicated, inoculated control pigs had bloody diarrhea, and 9 pigs died. In 2 additional trials, AIV administered prophylactically for 28 days at 55 or 110 mg/kg of feed prevented swine dysentery induced by tylosin-insensitive T hyodysenteriae strain B204. All of the inoculated principal pigs medicated with AIV at 55 or 110 mg/kg of feed or carbadox at 55 mg/kg of feed and the noninoculated sentinel pigs for each group had solid feces throughout the 56-day trial. In the nonmedicated, inoculated control groups, bloody diarrhea began at 4 to 5 days after inoculation was done, and 9 of 10 principal pigs and 6 of 9 sentinel pigs had dysentery; 2 pigs died. In the groups medicated with AIV at 27.5 or 5.5 mg/kg of feed, all 5 principal pigs and 3 or 4 sentinel pigs in each group had dysentery; 3 or 4 pigs in each group died. In the group medicated with tylosin at 110 mg/kg of feed, 7 of 10 principal pigs and all 9 sentinel pigs had dysentery; 1 pig died. (ABSTRACT TRUNCATED AT 250 WORDS)
Prevalence of and Risk Factors for Colonization by Methicillin-Resistant Staphylococcus aureus among Adults in Community Settings in Taiwan

ABSTRACT In order to determine the prevalence of methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) colonization among adults in community settings in Taiwan and identify its risk factors, we conducted the present study. For a 3-month period, we enrolled all adults who attended mandatory health examinations at three medical centers and signed the informed consent. Nasal swabs were taken for the isolation of S. aureus. For each MRSA isolate, we performed multilocus sequence typing, identification of the staphylococcal cassette chromosome mec, tests for the presence of the Panton-Valentine leukocidin gene, and tests for drug susceptibilities. Risk factors for MRSA colonization were determined. The results indicated that the MRSA colonization rate among adults in the community settings in Taiwan was 3.8% (119/3,098). Most MRSA isolates belonged to sequence type 59 (84.0%). Independent risk factors for MRSA colonization included the presence of household members less than 7 years old (P < 0.0001) and the use of antibiotics within the past year (P = 0.0031). Smoking appeared to be protective against MRSA colonization (P < 0.0001).
Typical Hesitant Fuzzy Negations

Since the seminal paper of fuzzy set theory by Zadeh in 1965, many extensions have been proposed to overcome the difficulty for assigning the membership degrees. In recent years, a new extension, the hesitant fuzzy sets, has attracted a lot of interest due to its usefulness to handle those problems in which it is difficult to provide accurately a single membership value; since for hesitant sets, membership values are given by a whole set of values. On the other hand, since fuzzy negations have an important role in applications as well as in the theoretical approach to of fuzzy logics, it is important to study an extension of the concept of fuzzy negation for hesitant fuzzy degrees (elements). In this paper, we propose such a definition and we study some of the main properties of this new concept.
Automatic rag classification using spectrally derived tone profiles

Rag is the central melodic concept of Indian art music. The current system classifies segments from rag performances beginning at the signal level based on a spectrally derived tone profile. A tone profile is essentially a histogram of note values weighted by duration. The method is shown to be highly accurate (100% accuracy) even when rags share the same scalar material and when segments are drawn from different instruments and different points in the performance. Rag identification has important applications in automatic transcription, genre classification and musical database queries.
Lecturers' perspective of student online feedback system: A case study

This paper presents the results of a questionnaire based survey that had the objectives to obtain the perception of lecturers on the benefits or otherwise of students online feedback systems. The case study was carried out in four engineering faculties of a Malaysian public university that uses an online student feedback system, termed SUFO. The main objective was to evaluate if the lecturers think that data from the online feedback system obtain via SUFO is fair and if it helps to improve their teaching quality. The results from lecturers' perception indicated that universities can use information from an online Student Feedback System to improve quality of teaching and learning.
Parents' and children's adiposity and eating style.

OBJECTIVE To investigate children's ability to self-regulate energy intake and to determine whether individual differences in the precision of food intake regulation are related to children's anthropometric measures. We collected information pertaining to parental adiposity and dieting practices, as well as mothers' child-feeding practices. Of special interest was the degree of control imposed by mothers over their children's food intake. Our intent was to explore whether these variables might influence children's regulation of energy intake. SUBJECTS AND SETTING Seventy-seven 3-5-year-old children who attended a university preschool setting and their parents participated in this experiment. MEASUREMENTS AND MAIN RESULTS Children completed controlled, two-part meals used to estimate their ability to adjust food intake in response to changes in caloric density of the diet. An eating index, reflecting children's precision in the ability to regulate energy intake, was correlated to children's anthropometric measures. These correlations provided evidence for a relation between children's body fat stores and their responsiveness to caloric density cues: Pearson correlation coefficients revealed that children with greater body fat stores were less able to regulate energy intake accurately. The best predictor of children's ability to regulate energy intake was parental control in the feeding situation: mothers who were more controlling of their children's food intake had children who showed less ability to self-regulate energy intake (r = -.67, P < .0001). CONCLUSIONS These findings suggest that the optimal environment for children's development of self-control of energy intake is that in which parents provide healthy food choices but allow children to assume control of how much they consume.
TRACKING CENTRAL HYPOVOLEMIA WITH ECG IN HUMANS: CAUTIONS FOR THE USE OF HEART PERIOD VARIABILITY IN PATIENT MONITORING

Heart period variability (HPV) metrics have been suggested for use in medical monitoring of trauma patients. This study sought to ascertain the use of various HPV metrics in tracking central blood volume during simulated hemorrhage in individual humans. One hundred one healthy nonsmoking volunteers (58 men, 43 women) were instrumented for continuous measurement of electrocardiogram and beat-by-beat finger arterial blood pressure. Stroke volume (SV) was estimated from the arterial pulse wave and used to reflect central blood volume. Progressive lower body negative pressure (LBNP) was applied in 5-min stages until the onset of impending hemodynamic decompensation (systolic blood pressure <70 mmHg and/or presyncopal symptoms). HPV was assessed with analysis of R-to-R intervals using both linear (time and frequency domains) and nonlinear (e.g., complexity, fractality) methods. Application of increasing LBNP caused progressive reductions of SV, whereas arterial pressures changed only minimally and late. Group LBNP stage means for each HPV metric changed progressively and were strongly correlated with the mean decrease in SV (|r| ≥ 0.87). To ascertain the utility of the HPV metrics to track individual responses to central hypovolemia, the difference scores for each HPV metric were correlated at each successive LBNP level, with percentage change in SV at the subject level. This cross-correlation of difference scores revealed that none of the HPV metrics showed strong and consistent correlations (|r| ≤ 0.49) with percentage change in SV across successive LBNP levels. Although aggregate group mean values for HPV metrics are well correlated with SV changes during central hypovolemia, these metrics are less reliable when tracking individual reductions in central volume during LBNP. HPV metrics, therefore, may not be useful in monitoring hemorrhagic injuries in individual patients.
Chaperone Function of Hsp90-Associated Proteins

The Hsp90 heat shock protein of eukaryotic cells regulates the activity of proteins involved in signal transduction pathways and may direct intracellular protein folding in general. Hsp90 performs at least part of its function in a complex with a specific set of partner proteins that include members of the prolyl isomerase family. The properties of the major components of the Hsp90 complex were examined through the use of in vitro protein folding assays. Two of the components, FKBP52 and p23, functioned as mechanistically distinct molecular chaperones. These results suggest the existence of a super-chaperone complex in the cytosol of eukaryotic cells.