Miracle-dz/UniFAR-FTUs huggingface dataset:
A new role for E2F1 in DNA repair

E2F1 is best known as the founding member of the E2F transcription factor family, which (together with retinoblastoma family proteins) regulates the expression of a large number of genes involved in DNA synthesis, cell cycle progression, DNA repair and apoptosis.1,2 E2F1 has also been implicated in responses to DNA damage, and E2F1 is posttranslationally modified and stabilized in response to DNA damage and recruited to DNA strand breaks (DSBs). Previous studies have shown that E2F1 promotes nucleotide excision repair of UV-induced DNA damage, contributing to enhanced cell survival post-exposure.3,4 A recent report by Chen et al. provides mechanistic teeth to previous associations between E2F1 and responses to DSBs by demonstrating a critical and direct role for E2F1 in the recruitment of repair factors to DSBs and subsequent repair, apparently independent of E2F1 roles in transcriptional regulation.5 Mutation or knockdown of E2F1, in both mouse and human cells, is shown to substantially reduce NBS1 phosphorylation, Rad51 accumulation and the formation of DNA damage foci containing Rad51, NBS1 and RPA. Importantly, the repair of DSBs is substantially delayed and reduced in cells with reduced E2F1. The formation of γH2AX foci is actually enhanced, because the resolution of the foci is delayed in E2F1-deficient cells following DNA damage. Thus, E2F1 appears to be required for the repair but not the recognition of DSBs.5 It remains to be determined how E2F1 mediates the recruitment of repair factors to DSBs, and the authors speculate that E2F1-dependent chromatin remodeling could contribute to effective repair. Thus, in addition to its ability to promote apoptosis in response to DNA damage, E2F1 can also mediate DNA repair, which should promote clonogenic survival (Fig. 1). Whether by promoting the repair or the elimination of cells with DNA damage, E2F1 should contribute to the maintenance of genomic integrity, limiting the propagation of cells with potential DNA mutations. It will be important to better understand how E2F1 contributes to the cellular decision to repair or die following DNA damage and what role E2F1 plays in tissue maintenance and carcinogenesis following genotoxic insults. In some ways, this role for E2F1 is reminiscent of p53’s divergent cell fate impacts following DNA damage, where it can either play a pro-survival role, by instituting a temporary cell cycle arrest to allow for repair, or pro-death/senescence roles, preventing the clonogenic maintenance of the cells.6 In addition, p53 may also play a direct role in the repair of DNA strand breaks, independent of its role in regulating transcription.7 Given the known relationship between E2F1 and p53, it will be interesting to tease out how the interplay between these factors can control cell fate decisions, contributing to the “greater good” of the tissue: repair and retain or eliminate from the replicative cell pool. Figure 1. E2F1 can either promote either DNA repair or apoptosis in response to DNA damage, which should exert opposing effects on cell survival.
Dynamic reserve allocation for system contingency by DFIG wind farms

Summary form only given. With the increasing wind penetration into the power system, the guidelines of operating reserve need to be revised to ensure system security. Due to the uncertain characteristics of the wind production, the general way of the reserve management for wind integration is to provide additional reserve margin by conventional plants. Such a strategy could not only increase the operating costs but also impose additional unit stress during the frequency event. This paper presents a strategy that incorporates doubly-fed induction generator (DFIG) wind farms to actively provide primary reserve for frequency control. The wind reserve allocation according to available wind speed is proposed. An integrated system that consists of the traditional units and DFIG wind farms has been developed to assess the frequency response and generating interactions. Simulation results are discussed to illustrate the superiority of the presented strategy in reserve operation.
Laser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review

Objective: Laser-assisted uvulopalatoplasty (LAUP) has been used as a treatment option for snoring and obstructive sleep apnea for almost three decades. It has been previously reported that some patient’s sleep-disordered breathing worsened following surgery. The aim of this paper is to further elucidate the specific complications of LAUP. Data sources: A systematic search of the electronic databases MEDLINE/PubMed, Google Scholar, and Embase. Review methods: The PRISMA statement was followed. Databases were searched from inception through September 2, 2018. The following search was applied to MEDLINE/PubMed ((laser AND uvul*) OR (LAUP) OR (LAVP) OR (laser AND (apnea OR apnoea OR sleep))). Results: Forty-two studies with a mean follow-up of 16.1 months reported complications on 3,093 total patients who underwent LAUP. The percentages and associated complications of LAUP are as follows: bleeding (2.6%), candidiasis (0.3%), dryness (7.2%), dysgeusia (0.3%), dysosmia (0.2%), globus sensation (8.2%), surgical site infection (1.3%), velopharyngeal (VP) insufficiency (3.9%), and VP stenosis (1.6%). The mean duration of patient-reported pain in studies that reported pain was 11.65 days. Only globus and VP insufficiency had a significant incidence compared with either the general population or the post-oropharyngeal surgery population with relative risks of 1.48 and 2.25, respectively. Overall, there were approximately 26 complications per 100 patients who underwent LAUP. Conclusion: LAUP is associated with a statistically significant rate of VP insufficiency and globus sensation; however, studies lack details of surgical approaches, suggesting that in a population identified as good candidates, a tissue-sparing approach may result in fewer complications.
Sozialpolitik in Deutschland : historische Entwicklung und internationaler Vergleich

Sozialpolitik in Deutschland: vom Deutschen Reich von 1871 bis zur Bundesrepublik Deutschland im fruhen 21. Jahrhundert - Historisch und international vergleichende Analysen - Politische, gesellschaftliche und wirtschaftliche Wirkungen der Sozialpolitik
Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer.

Eastern VA Medical School, Norfolk, Virginia; McGill University Health Center, McGill University, Montreal, Canada; Icahn School of Medicine at Mount Sinai, New York, New York; VA Puget Sound Health Care System and University of Washington, Seattle, Washington; Veterans Affairs Palo Alto, Stanford University School of Medicine, Palo Alto, California; VA Medical Center; Geisel School of Medicine at Dartmouth, White River Junction, Vermont; Baylor University Medical Center, Dallas, Texas; Johns Hopkins University School of Medicine, Baltimore, Maryland; Oregon Health and Science University, Portland, Oregon; Kaiser Permanente Medical Center, Walnut Creek, California; Indiana University School of Medicine, Indianapolis, Indiana
Transkranielle Sonografie des Hirnparenchyms: etablierte Anwendungen bei Erwachsenen

Zusammenfassung Die transkranielle B-Bild-Sonografie (TCS) ist eine Bildgebungsmodalität, die das Hirnparenchym und das intrakranielle Ventrikelsystem bei intakter Schädelkalotte darstellt. Im Vergleich zur Magnetresonanztomografie kann die TCS tiefe echogene Hirnstrukturen mit höherer Bildauflösung darstellen und hat zudem die Vorteile hoher Mobilität, gesundheitlicher Unbedenklichkeit und geringer Störbarkeit durch Patientenbewegungen. Das eigenständige Bildgebungsprinzip der TCS erlaubt die Visualisierung charakteristischer Veränderungen bei diversen neurodegenerativen Erkrankungen, die mit anderen Verfahren nur schwierig darstellbar sind, wie die Hyperechogenität der Substantia nigra bei idiopathischem Parkinson-Syndrom und die Hyperechogenität des Nucleus lentiformis bei atypischen Parkinson-Syndromen. Etablierten Anwendungen der TCS sind das bettseitige Monitoring raumfordernder Läsionen (intrakranielle Blutungen, maligne Hirninfarkte) bei akuten Schlaganfallpatienten, die Früh- und Differenzialdiagnose des Parkinson-Syndroms, und die postoperative Positionskontrolle von Tiefenhirnstimulations-Elektroden. Neue Technologien wie die Echtzeit-MRT-TCS-Fusionsbildgebung und die digitalisierte Bildanalyse versprechen eine breitere Anwendung der TCS in den kommenden Jahren.
Predictive promoter activity in soybean using a novel cell-suspension culture and transient expression analysis in protoplasts

Transient reporter gene assays can be a valuable tool to rapidly measure expression of heterologous promoters. The challenge for maximizing the value of such screens is to combine relevant cells or tissues with methods that can be scaled for high throughput screening, especially for croprather than model species. We describe herein a novel leaf-derived soybean cell suspension culture (LDSC) that is amenable for a low-cost method for protoplast isolation, which was used for screening endogenous promoters. LDSC-derived protoplasts were validated against known promoter expression profiles from tissue-derived protoplasts (leaves, stems and immature cotyledons). LDSCs can reliably produce 2.82 ± 0.94×10 protoplasts/g fresh culture mass with a transfection efficiency of 30.65 ± 2.70% at 48 hours after transfection. Transfected LDSC-derived protoplasts harboring promoter-reporter gene DNA expression levels were similar to
EPS II: estate planning with prototypes

This paper discusses our preliminary research into the possibility of developing a true legal planning system. To date, almost all legal expert systems have been legal analysis systems [8], but, in many domains, legal planning prior to taking an action is much more important than analyzing the legal consequences of an action after the fact. For example, the principal activity of business and tax attorneys is not litigation, but rather assisting clients in planning their affairs so as to avoid litigation in the future.
Class-Oriented Discriminative Dictionary Learning for Image Classification

Dictionary learning has emerged as a powerful tool for a range of image processing applications and a proper dictionary always plays a key issue to the final achievable performance. In this paper, a class-oriented discriminative dictionary learning (CODDL) method is presented for image classification applications. It takes a comprehensive consideration of multiple optimization objectives, emphasizing class discrimination of both dictionary atoms and representation coefficients. The atoms of the learned dictionary should be grouped into class level sub-dictionaries. Meanwhile, the sparse representation coefficients of an input sample should be concentrated on the sub-dictionary of the class it belongs to. Then, based on the learned class-oriented discriminative dictionary, the structured representation coefficients can thus be used for image classification with a simple and efficient classification scheme. The superior performance of the proposed algorithm is demonstrated through extensive experiments.
HRD climate in selected public sector banks in India

Human resource development (HRD) climate is very important for organization towards growth. Here employee perception towards HRD climate in selected public sector banks is studied where dimension of HRD climate divided into general climate, OCTAPACE culture & HRD mechanism. Data were collected from 100 employees through well-defined and structured questionnaire comprising of 38 items. Findings revealed that HRD climate in is good (average) and the perception towards the climate is not deferring significantly towards gender, qualification and designation except age.
Design of multiple-input power converter for hybrid vehicles

This paper deals with designing and sizing of a multiple-input power electronic converter (MIPEC) to be used in an electric vehicle propulsion system that includes a fuel cell (FC) generator and a combined storage unit. The combined storage unit is composed by an ultracapacitors tank (UC) and a battery unit (BU). MIPEC is responsible for power-flow management on-board the vehicle for each mode of operation. Specifications for MIPEC designing come out from many considerations concerning traction drive and reference driving cycle, on-board power source and storage unit characteristics. However, to date sizing and configuration of both storage units and on-board generators are directly related to traction drive and driving profile (i.e., vehicle performances and characteristics) and no relation with power electronic interface is considered during preliminary design. Then, power electronic interface is selected in order to fit traction drive requirements with power source and storage unit characteristics; as a consequence converter mode of operation lacks of optimization, as well dynamic behavior and efficiency cannot be maximized. In this paper, MIPEC design and power source and storage unit selection are achieved at the same project stage according to traction drive requirements. Experimental results on 60-kW power electronic interface are presented.
John P Wihbey, The Social Fact: News and Knowledge in a Networked World

How the structure of news, information, and knowledge is evolving and how news media can foster social connection.While the public believes that journalism remains crucial for democracy, there is a general sense that the news media are performing this role poorly. In The Social Fact, John Wihbey makes the case that journalism can better serve democracy by focusing on ways of fostering social connection. Wihbey explores how the structure of news, information, and knowledge and their flow through society are changing, and he considers ways in which news media can demonstrate the highest possible societal value in the context of these changes.Wihbey examines network science as well as the interplay between information and communications technologies (ICTs) and the structure of knowledge in society. He discusses the underlying patterns that characterize our increasingly networked world of information? with its viral phenomena and whiplash-inducing trends, its extremes and surprises. How can the traditional media world be reconciled with the world of social, peer-to-peer platforms, crowdsourcing, and user-generated content? Wihbey outlines a synthesis for news producers and advocates innovation in approach, form, and purpose. The Social Fact provides a valuable framework for doing audience-engaged media work of many kinds in our networked, hybrid media environment. It will be of interest to all those concerned about the future of news and public affairs.
Spotty liver disease

Spotty Liver Disease has become common in the Australian layer industry. Campylobacter hepaticus, the bacterial pathogen that causes the disease, has recently been identified and characterised. Following on from the initial discovery of the causative pathogen, whole genome sequencing of a collection of isolates has been carried out and molecular assays have been developed. The molecular assays allow culture free detection and quantification of C. hepaticus in microbially complex samples such as gastrointestinal tract samples. In addition, a multiplex PCR assay has been developed to that is capable of simultaneous detection of C. hepaticus, C. jejuni, and C. coli.
Symplectic Gram-Schmidt Algorithm with Re-Orthogonalization

: The preservation of symplectic Gram Schmidt J-orthogonality is crucial for structure preserving methods for the eigenvalue problem. In this paper, we present the symplectic Gram-Schmidt algorithm with re-orthogonalization and we study the re-capture of the J-orthogonality of vectors generated by the algorithm. Furthermore, the re-orthogonalization process is combined with a careful choice of the free parameters that was involved in the algorithm to ensure satisfactory re-capture of the J-orthogonality. Some numerical experiments and computational aspects are given to confirm the superiority of the algorithm.
Review on Some Plants’ Therapeutic Effects against Gastrointestinal Microbes

Plants play vital roles in many health care systems, be it rural or an urban community. Plants became familiar as medicine due to the primordial ideologies and believed. Several plant parts served as medicines to so many ailments including gastrointestinal ailments, due to the fact that their active ingredients are powerful against the microbes as well as healing so many physiological abnormalities. The principal antimicrobial components were used to inhibit the growth of microbes (S. aureus, E. coli, Salmonella spp, B. cereus, and B. subtili,), as well as most of the recognized compounds in most plants were aromatic or saturated organic compounds which enabled the plants to be active against the gastrointestinal microbes. The commonly used diluents were; water, methanol and Di methyl sulphate oxides to ascertain the level of activity of the plants. As such, plant materials in one way or the other are very active when dealing with microbes due to their active ingredients or the phytoconstituents. Most of the microbes identified in many reviewed researches were enteric bacterial species, by which divided into both gram negative and gram positive bacterial isolates, they differ in their cell components, which are the main targets of bioactive constituents to deal with any bacteria. However, certain parasites contributed towards the production of ailments for their survival and causing havoc to the hosts and sometimes be mutualistic.
Türkiye’de 1994, 2001 ve 2008-9 Ekonomik Krizlerinin Karşılaştırmalı Analizi

Turkiye ekonomisinin son onalti yilda karsilastigi para ve bankacilik krizleri, sermaye hesabini serbestlestirmis bazi gelismekte olan ulkeler (GOU)’deki finansal ve fiskal kirilganliga atfedilen krizler baglaminda mutalaa edilmektedir. Spekulatif sermaye hareketlerindeki ani yon ve hacim degisiklikleri Turkiye’nin uc krizinde ortak ve tetikleyici oge olarak gozlenmekle birlikte, soz konusu uc kriz, uluslararasi ve ulusal ortam ve kosullar acisindan farkliliklar gostermektedir. Uluslararasi planda, sermaye akimlarinin hacim, bilesim ve oynakligi, yerel krizin evrimini ve siddetini etkilemektedir. Her uc krizde, kur ve talep idaresi politikalarinin uygulanma bicimi ile kurumsal yapilanmaya verilen onem ve oncelikler degismistir. Yazida ilkin GOU’deki para ve bankacilik krizleri ile ilgili tanim, gozlem ve aciklamalar sunulmakta, daha sonra odemeler dengesi, finans ve kamu maliyesi alanlarindan secilmis gostergelerin, kriz oncesinde, kriz suresinde ve kriz sonrasinda nasil davrandigi sergilenmekte, hangi oran ve/veya parametrelerden oncu gostergeler olarak yararlanilabilecegi tartisilmaktadir. Turkiye’nin yasadigi son uc kriz, sadece Turkiye’nin iktisat politikasi hatalarindan degil, uluslararasi ekonomik duzenin isleyisiyle ilgili, sistemik nedenlerden de kaynaklanmaktadir. Hukumetlerin dis soklari ulkeye tasiyan aktarim mekanizmalari uzerinde etkili olabilecek onlemler almaktan kacinmalari, bu tur krizlerin orta vadede yinelenebilecegini dusundurmektedir.
Cross-border workers and financial instability: a frequency domain causality analysis applied to the Luxembourg financial centre

ABSTRACT This paper aims to examine the causal relationship between workers (cross-border and resident workers) and financial instability in the Luxembourg financial centre, using a Granger causality test in the frequency domain. The evidence shows that cross-border workers are more sensitive to financial shocks than resident workers. In addition to the causal relationship there is a ‘nonlinear’ reaction: one smooth in the short term and a second more structural one in the long term.
Identity Performance Among Muslim International Women: A Narrative Inquiry

ii Dedication . iv Acknowledgements . v List of Tables . xi Chapter One: Introduction . 1 International Students, Muslim Students, and Gendered Islamophobia . 2 Muslim, International, and Women College Students . 4 Campus Climate . 5 Conceptualizing Muslim International Women’s College Experiences: Microsystems . 8 Identity Performance . 9 Purpose of the Study and Research Questions . 11 Definition of Terms . 12 Significance of the Study . 14 Delimitations . 16 Organization of the Study . 17 Chapter Two: Literature Review . 18 Islam and Muslims . 18 Islamophobia and Gendered Islamophobia . 21 Muslim Undergraduate College Students . 24 Campus Climate . 28 Identity . 32 Developmental Psychology . 32 Sociology . 33 Social Psychology . 37 Model of Multiple Dimensions of Identity . 37 Human and Developmental Ecology . 39 Bronfenbrenner's Ecological Systems Theory (1979) . 41 Conclusion . 44 Chapter Three: Methodology . 46
Accelerating ultrasound speed of sound tomography through reflection and transmission imaging

Imaging of speed of sound holds great promise for medical detection and diagnosis since it is a quantitative, physical property of tissues not imaged by other means. The full Waveform Inversion (FWI) based method can build speed of sound images with high spatial resolution but it is computationally very demanding. The iterative Algebraic Reconstruction Technique (ART) is a favored choice for fast projection reconstruction problems, but its convergence, like that of other algorithms, is strongly limited when used for limited angle tomography, i.e. tomography without full 360° projection data. Limited angle ART is prone to yield inaccurate results and directionally dependent artifacts. Other speed of sound (SOS) imaging methods with fast reconstruction properties can only provide coarse resolution with high variance and bias. Here, we propose a fast SOS imaging method with good quantitative and spatial fidelity.
Linear Degrees of Freedom of Full-Duplex Cellular Networks With Reconfigurable Antennas

In this paper, we characterize the linear degrees of freedom (DoF) of a cellular network in which the base station (BS) operates in a full-duplex (FD) mode and the users operate in a half-duplex mode. We assume that the BS and the users are equipped with reconfigurable antennas which can be switched between their preset modes. We consider two practical scenarios for different assumptions on channel state information at the transmit sides (CSIT), referred to as no CSIT and partial CSIT models. To derive the inner-bounds for two scenarios, we propose a new achievable scheme which enables interference alignment between uplink and downlink interference signals at each user via preset mode switching of reconfigurable antennas. The key concept of our scheme is to align the interference signals of uplink transmission at the downlink users, through the identical preset mode pattern over the multiple of downlink transmission periods and silence periods of the BS. We also develop an outer-bound on the linear sum DoF of the cellular network for the no CSIT model, which matches up with the inner-bound. Moreover, we also provide a natural variant of the proposed scheme when considering residual self-interference at the FD BS, which can alleviate the shortcoming of the existing self-interference cancellation techniques.
30% static power improvement on ARM Cortex®-A53 using static Biasing-Anticipation

This paper presents an energy efficiency improvement methodology based on the use of additional static biasing instead of margins during design stage. While the impact of margins used to prevent unsystematic process limitations cannot be recovered after fabrication, using biasing anticipation offers the possibility to enable the degradation recovery only when it is required. A CAD study on ARM Cortex®-M4 Microcontrollers (MCU) showed up to 50% of static current reduction at typical corner, nominal voltage, compared to the margin-based methodology. An implementation of a 1GHz ARM Cortex®-A53 core in 28nm fully-depleted silicon-on-insulator (FD-SOI) was performed using this methodology, and silicon measurements on 60 dies confirmed up to 30% median static power improvements.