Miracle-dz/UniFAR-FTUs huggingface dataset:
Tek Seviye Anterior Servikal Diskektomi ve Füzyon Sonrası Servikal Sagittal Dizilimin değerlendirilmesi; Klinik Seri

Oz: Giris: Servikal dizilim yasam kalitesi ve myelopatiyle iliskilidir. Anterior servikal diskektomi ve fuzyon’un amaci noral yapilari dekomprese etmek, servikal dizilimi korumak ve/veya restore etmektir. Bu calismanin amaci gunumuzde yaygin olarak kullanilan anterior servikal diskektomi ve fuzyon’un servikal sagittal dizilim uzerine etkisini degerlendirmektir. Materyal ve Metot: Biz retrospektif olarak tek seviye anterior servikal diskektomi ve fuzyon uygulanan 16 hastayi ortalama 16 ay takip edilmesi ardindan radyolojik olarak servikal sagittal dizilimi ve klinik sonuclarini degerlendirdik. Bulgular: Preoperatif ve postoperatif 12.ayda olculen servikal sagittal dizilim parametrelerinde istatistiksel olarak anlamli fark bulunmazken; hastalarin preoperatif ve postoperatif 12.ayda degerlendirilen Vizuel analog skala degerlerinde anlamli bir fark gozlendi. Sonuc: Tek seviye anterior servikal diskektomi ve fuzyon sonrasi radyolojik olarak anlamli bir fark cikmasa bile klinik olarak hastalarda belirgin bir iyilesme gozlenmistir.
Circulating RNA in blood plasma as diagnostic tool for clinical oncology

One of the key challenges facing today’s oncology is the discovery of early predictors of malignant neoplasms in patients’ biological samples. Liquid biopsy is a noninvasive diagnostic technique based on the detection and isolation of tumor cells, tumor-derived nucleic acid and exosomes circulating in the blood plasma of cancer patients. There is a plethora of research studies of circulating tumor DNA in patients with MN. The active proliferation of tumor cells occurs in the backdrop of altered gene expression. The presence of tissue-specific transcripts in the circulating RNA fraction suggests that levels of circulating RNA reflect the development of the primary tumor. We think that cell-free RNA circulating in the blood plasma is a promising molecular biomarker for early cancer detection.
Deteksi Twitter Bot menggunakan Klasifikasi Decision Tree

Advance development of social media application has affected to human lifestyle. Everyone can obtain information from social media easyly. Its become easier to communicate each other using social media. Twitter is one of the fastest growing social media application. Deliver good and hoax information from one user to another. Event there are alot of fake account (bot) in Twitter. This objection of this study is to detect Twitter Bot accounts on Twitter social media by using the Decission Tree classification. Experiment results show the accuracy performance of the Decision Tree model reached 88.84% and UC curve by 0.965. Its shows that the Decision Tree classification is excellent in detecting Twitter Bot accounts. Keywords—Decision Tree, Classification, Machine Learning, Twitter Bot, Detection System. Intisari— Perkembangan media sosial menjadikannya sebagai kebutuhan manusia dalam berkomunikasi pada saat ini. Berbagai informasi dapat diperoleh pengguna dari media sosial. Informasi tersebut ada yang bersifat benar, ada juga yang bersifat salah. Salah satu media sosial yang sangat digemari adalah Twitter. Namun tidak jarang, akun yang berada pada aplikasi Twitter merupakan akun palsu (Bot). Penelitian ini bertujuan untuk melakukan pendeteksian akun Twitter Bot pada media sosial Twitter dengan menggunakan klasifikasi Decission Tree. Hasil pengukuran menunjukkan performa accuracy model Decision Tree mencapai 88.84% dan perhitungan kurva AUC dengan nilai 0.965. Hal tersebut menunjukkan bahwa klasifikasi Decision Tree sangat sesuai dalam pendeteksian akun Twitter Bot. Kata kunci—Decision Tree, Klasifikasi, Machine Learning, Twitter Bot, Sistem Deteksi.
State Severity Assessment in Patients with Obstructive Jaundice using PMGMU2018h Scale Adapted to the Russian Medical and Economic Standards

The aim of the study was to assess the effectivity of PMGMU2018h scale for evaluation of the state severity degree of patients suffering from obstructive jaundice relative to other common assessment scales. Materials and Methods. Thirty physical parameters have been studied and compared according to different assessment scales in each of 258 patients with obstructive jaundice treated in three medical settings. Results. The main drawback of the examined scales is the necessity to use the parameters for calculations not included in the medical and economic standards of the Russian Federation. This feature makes these scales unsuitable for making decisions on the tactics of managing a concrete patient in the hospitals of the Russian Federation. The scale developed by us for the assessment of the state severity of patients suffering from obstructive jaundice is completely devoid of subjectivism, does not depend on a surgeon’s qualifications, and possesses high specificity to the given disease.
Heart Rate and ECG Wireless Monitoring Techniques: A Survey

Body health monitoring is so important to us for ensure that our health is in an excellent case. The systems for Health monitoring are a new subject and significant research scope nowadays. There are many significant vital parameters in the health observing systems, Heart Rate (HR) is one of the most important signs of these parameter to be monitor; it is a vital indicator of people’s physiological state. Monitoring of heart rate oftentimes includes high costs and complex application of sensors and its systems. Therefore to cover this needed it must advance systems that are able to measure HR and ECG systems for the purpose of monitoring. This paper focuses on reviewing the monitoring of the heart rate systems with the uses of a fingertip sensor and electrocardiogram other remote technologies. More than forty of the heart rate measuring and observing systems and Electrocardiogram systems have reviewed and grouped into two groups one for heart rate and the other for wearable ECG, presented its features and common specifications for each of them, resulting from this review that the authors have focused on designing systems that can be optimum choice for illness people which they have needed to be continuous monitoring. The systems are acceptable error rate and some of them allow the user to freely move based on the wireless technology, the systems easy for usage by the patient or elder people and with a suitable cost. Also, this paper presents security, personality, reliability of systems and the quality of the signal.
Research and Prospect of Image Recognition Based on Convolutional Neural Network

This paper compares common image recognition technology, introduces three image recognition and classification technologies, and explains the most popular deep learning image recognition algorithm based on CNN in detail. As a new method of ANN, CNN combines ANN and deep learning technology. In the area of image recognition, the advantage of CNN is particularly prominent. Compared with the traditional image processing algorithm, CNN has higher recognition accuracy and speed, and can directly process the original image to avoid the complicated pre-processing image data. CNN is the first choice for image recognition.
Effects of radiation quality, intensity, and duration on photosynthesis and growth

photosynthesis. Plant scientists continue to grossly underestimate the magnitude and importance of side lighting in single-plant studies. The reflective walls of growth chambers mean that side light intensity is only slightly less than that from the top. If a single, spaced plant is considered to be spherical rather than circular, the surface area for radiation interception changes from π 2 to 4π 2 , a 400% increase. Even if only the top half of the sphere is exposed to light, the surface area and thus light absorption are still twice that of a circle. In many studies, plant surface area and radiation absorption should be analyzed as a cylinder determined by plant height and width, rather than as a circle determined by width only. Side lighting means that tall plants intercept more photons and will have a higher growth rate than short plants, even when the irradiance level is identical at the top of the plants. It is important to distinguish between radiation absorption and photosynthesis because the increases in growth or width caused by increased side lighting do not occur in plant communities where plants form a closed canopy and mutual shading eliminates side lighting. In our studies with wheat canopies, elevated CO 2 increased photosynthesis, which increased tillering (branching) and lateral spread at the edges of the plant canopy. Precise measurements of the canopy-absorbing area showed that half of the CO 2 effect was caused by increased radiation absorption. The direct CO 2 effect on photosynthesis was only about 50% of what we originally measured. Small increases in lateral spread cause surprisingly large increases in radiation absorption. Figure 1 shows how a 10% increase in lateral spread of a wheat canopy resulted in a 24% increase in plant surface area causing a similar increase in growth rate and a corresponding overestimation of the effect of CO 2 on plant growth per unit surface area. Fig. 1. The effect of a 10% increase in lateral spread (5 cm on all sides) on surface area of a plant canopy. The planted surface area was 0.8 m 2 . The actual plant growth area was 0.99 m 2 , resulting in a 24% increase in final/initial surface area. Small increases at the perimeter cause large increases in surface area.
Non-Volcanic Earthquake Swarm Near the Harrat Lunayyir Volcanic Field, Saudi Arabia

Special thanks to Derek Keir, Finnigan Illsley-Kemp (University of Southampton), Jose A. Lopez Comino (KAUST and now at University of Granada), and Kiran K. Thingbaijam (KAUST) for the fruitful discussions which include suggesting FI technique and enhancing the moment tensor inversion and stress drop analyses. We wish to thank Felix Waldhauser (Lamont Doherty Earth Observatory) for providing the latest unpublished version of his code (HypoDD of 2019). Our project received financial support from King Abdullah University of Science and technology (KAUST) under the CRG grant (ORS-2016-CRG5-3027-0). All waveform data were obtained through the Saudi Geological Survey (SGS) and is available from Harvard Dataverses webpage (https://doi.org/10.7910/dvn/kw4zfx).
Abandoning Galileo’s Ship: The Quest for Non-relational Empirical Significance

The recent debate about whether gauge symmetries can be empirically significant has focused on the possibility of 'Galileo's ship' types of scenarios, where the symmetries effect relational differences between a subsystem and the environment. However, it has gone largely unremarked that apart from such Galileo's ship scenarios, Greaves and Wallace (2014) proposed that gauge transformations can also be empirically significant in a 'non-relational' manner that is analogous to a Faraday-cage scenario, where the subsystem symmetry is related to a change in a charged boundary state. In this paper, we investigate the question of whether such non-relational scenarios are possible for gauge theories. Remarkably, the answer to this question turns out to be closely related to a foundational puzzle that has driven a host of recent developments at the frontiers of theoretical physics. By drawing on these recent developments, we show that a very natural way of elaborating on Greaves and Wallace's claim of non-relational empirical significance for gauge symmetry is incoherent. However, we also argue that much of what they suggest is correct in spirit: one can indeed construct non-relational models of the kind they sketch, albeit ones where the empirical significance is not witnessed by a gauge symmetry but instead by a superficially similar boundary symmetry. Furthermore, the latter casts doubt on whether one really abandons Galileo's ship in such scenarios.
AB0121 ASSESSMENT OF GLOBAL DNA METHYLATION IN PERIPHERAL BLOOD CELL SUBPOPULATIONS OF PATIENTS WITH AXIAL SPONDYLOARTHRITIS: PRELIMINARY RESULTS

Background: Axial spondyloarthritis (ax-SpA) corresponds to a group of chronic inflammatory disease mainly affecting the axial skeleton. TNFα and IL-17A have been identified as key inflammatory mediators driving the inflammatory process of ax-SpA. Epigenetics refers to different mechanisms that alter gene expression without involving changes in DNA sequence. The mechanisms of epigenetics include microRNA, histone modifications or DNA methylation. DNA methylation is associated with a repressed chromatin state and inhibition of gene expression. It is recognized that aberrant DNA methylation can result in immune cell autoreactivity. Objectives: Epigenetics have been rarely evaluated in ax-SpA. We previoulsy reported that patients with ankysloing spondylitis (AS) had an imbalance between HAT and HDAC activities. In this study, we aimed to evaluate the global DNA methylation of patients with ax-SpA. Methods: Case-control study (NCT03092583). Patients with radiographic (AS) or non radiographic (nr) ax-SpA (ASAS criteria) and healthy controls (HC) were evaluated. All the patients were biologic naïve and under NSAIDs. Disease activity was evaluated by BASDAI and ASDAS. CD4+T cells and CD14+ monocytes were isolated form peripheral blood and then DNA was extracted (E.Z.N.A. Blood DNA kit, Omega Bio-Tek). Global DNA methylation (5-mC) was determined using MethylAmp global DNA methylation quantification kit (Epigentek) using 150ng of total DNA. Results: 25 patients with AS (18 M; mean age ± SEM: 48.9 ± 3.5 y; mean disease duration: 14.9 ± 2.2 y; B27+: 84%), 21 with nr-axSpA (11 M; age: 42 ± 3.3 y; disease duration: 7.9 ± 2.3 y; B27+: 68%) and 11 HC (7 M; age: 48.4 ± 3.9 y) were evaluated. Patients had active disease (BASDAI and ASDAS in AS and nr-axSpA: 5.1 ± 0.4 and 5.4 ± 0.5; 4.7 ± 0.4 and 5 ± 0.4, respectively). In CD4+ T lymphocytes, global DNA methylation was lower in the whole group of patients (AS and nr-ax-SpA) compared to HC (0.91 ± 0.26 vs 1.08 ± 0.19 % of 5-mC) (NS). Conversely, DNA methylation was higher in monocytes from patients compared to HC (1.43 ± 0.16 vs 1.15 ± 0.5 % of 5-mC) (NS). When analysing the results between ax-SpA subgroups, an hypomethylation was more evident in the CD4+T lymphocytes from patients with nr-axSpA compared to AS and HC, a result that was not observed in the monocyte subpopulation (Figures). Conclusion: A global DNA hypomethylation is observed in patients with ax-SpA, especially in the nr-axSpA subgroup. These results are more evident in T CD4+ lymphocytes. Additional analysis on a larger series of patients is required to confirm these preliminary results. In addition, we aim to examine the specific DNA methylation status of the TNF promoter gene. References: [1]Toussirot E et al, PlosOne 2013Figure. global DNA methylation of CD4+ T lymphocytes and monocyctes from patients with ankylosing spondylitis (AS), non radiographic axial spondyloarthritis (nr-ax-SpA) and healthy controls (HC) Disclosure of Interests: None declared
Winning votes and influencing people: campaigning in Central and Eastern Europe

ABSTRACT Using comparative data, we find that direct contact with voters is lower in CEE than elsewhere, although there are stark differences between CEE countries. Leafleting was the main form of contact, but the use of social media was higher in CEE than in Western Europe. Perennial parties are the most likely to contact citizens using personalised modes while the “accepted truth” that new entrants are more likely to use social media does not hold up. Our study shows the importance of direct contact on turnout which has significant ramifications for addressing the level of voter engagement in CEE countries.
The Impact of Service Quality Dimensions on Patient Satisfaction and Loyalty Using the Modified Servqual Scala at dr. Abdoer Rahem Situbondo Hospital

The focus of this study is on the influence of the quality of hospital inpatient health services according to the modified SERVQUAL scala dimension on patient satisfaction and loyalty. Satisfaction plays a role as a mediator of service quality in creating patient loyalty. With a sample of 400 inpatients participating in this study through a questionnaire survey with 15 questionnaires not returned / not answered completely. Samples were taken randomly from patients who received inpatient services with a purposive sampling method. Data were analyzed by path analysis using the SPSS program. The results of the study indicate that the quality of health services concerning the dimensions of trustworthness, communication, infrastructural quality, emphaty and responsiveness have a positive and significant effect on patient satisfaction in the inpatient installation of RSUD dr. Abdoer Rahem Situbondo with the dimension of responsiveness that has the greatest impact on satisfaction; The quality of health services regarding the dimensions of trustworthness, communication, emphaty, reliability and responsiveness through patient satisfaction have a positive and significant effect on patient loyalty in the inpatient installation of RSUD dr. Abdoer Rahem Situbondo but the personnel, healthscape, infrastructural quality does not have a significant effect. Patient satisfaction at the inpatient facility has a positive and significant effect on patient loyalty. Keyword: Hospital, Servqual, satisfaction and loyalty
Pluralismo ou privilégio Participação e mediação re-elitizadas

A great deal of the contemporary scientific knowledge production presents technology as an independent variable in processes of civic participation of political nature. It is for that significant part of the analysis and proposals presented in this subject that an alternative, pragmatic, view of the theory of the elites should be offered: that a organized smaller social groups of web users, from the vantage point of their privileged position, command/transform society. In this way, what begins as a project of alleged replanting of the political system becomes the recognition of its impracticability. Based on data resulting from the Sociedade em Rede projects of 2003 and 2013, this article intends to show that the availability of virtual spaces for civic political participation did not translate neither into greater equality in it, nor in reducing pre-existing limits and conditions of participation or explaining the factors underlying it. As such, one of the main dimensions to be considered in this context is the prevalence of the action of elites, resorting to an elitist competitive democratic theory, of explanatory potential much superior.
Effects of MMP-2 activation and FSH or LH Hormone Supplementation on Embryo Development in In Vitro Fertilization of Porcine

The purpose of this study was to analyze whether FSH and LH hormone treatment directly or indirectly affect embryo development in embryonic development. To determine this, we compared the development of embryonic cells through the expression pattern of MMPs. As a result, 33.8% of blastocysts were formed in FSH added group, 20.8% in LH added group and 10% in FSH + LH added group. In addition, the activity of MMP-9 was highly detected in the FSH-added group, and the expression of Casp-3 was much lower than that of the other groups. These results suggest that the addition of FSH seems to increase the activity of MMP-9 in embryonic cells, and that LH, on the contrary, may activate MMP-2 activity. In addition, the expression level of MMP-2 in the FSH-added group was high in the Trophoblast cell group and in the LH-added group, the hormone ideal secretion might affect the development of the embryonic cell.
From Neuroinflammation to Neuroprotection: Focus on Potential New Therapeutic Targets in Cognitive Impairment

Neurodegeneration is closely linked to neuroinflammation. It is often associated with oxidative stress and meaningful changes in cell energy metabolism. Neuroinflammation is due to non-neuronal cell activation (microglia, astrocytes, mast cells) activation and proliferation. Also, it is associated with pro-inflammatory substances release, able to modify synaptic plasticity. Microglia and astrocytes activation lead to toxic agent’s release (reactive oxygen species, inflammatory cytokines); however, the final target of this process is the cholinergic neuron. A number of substances can promote neuroprotection; recent scientific evidence focuses on the role of sirtuins. In particular, SIRT1 is activated by caloric restriction, NAD biosynthesis and different activators, called STACs (Sirtuin Activating Compounds). Citicoline is one of the most powerful STACs. It has been widely shown to possess neuroprotective action, and lots of studies strengthened its possible role.
Partager la production des connaissances en violence conjugale

Le present article propose un retour sur la demarche de recherche, experimentee dans le cadre d’un projet faisant partie de la programmation de TRAJETVI. Ce vaste projet soutient depuis 2013 differentes recherches menees en partenariat sur les violences faites aux femmes vecues en contexte conjugal. La perspective feministe intersectionnelle dans laquelle ce projet inscrit son approche implique de s’attarder aux differents rapports de pouvoir impliques dans les processus de production du savoir. Les resultats obtenus reiterent l’importance de mieux soutenir les partenaires des milieux de pratique, qui portent souvent seul.es la responsabilite du projet au sein de leur organisme, de se doter d’un echeancier realiste ainsi que d’un plan de mobilisation des connaissances qui permet l’appropriation des resultats par toutes les parties impliquees.
MIF-CD74 interaction as a promising target in drug discovery

MIF is a cytokine that plays a key role in innate and adaptive immune responses. Its activity has been associated with the development of multiple inflammatory diseases and cancer. MIF exerts its biological functions through the interaction with its cellular receptors such as CD74. Hence, MIF-CD74 binding is considered to be a promising target in the development of therapeutics for MIF cytokine-related diseases. We successfully improve the production of the purified CD74 protein in bacteria in order to provide a suitable MIF-CD74 binding assay. Furthermore, we have developed novel types of MIF inhibitors. The first type was identified from a collection of diversely-substituted compounds with a chromene scaffold. Screening of this compound collection yielded several hit compounds with IC50’s in the low micromolar range. Preincubation and dilution assays indicated that the inhibitors bind to MIF reversibly. Enzyme kinetic analysis of the most potent inhibitor showed that the inhibitor does not bind in direct competition with the substrate 4-HPP. Further characterization of the newly identified inhibitors in MIF-CD74 interaction assays is needed, as well as further characterizations in MIF cytokine-activity assays and in relevant disease models. For the second type of MIF inhibitors we employed structure-based design starting from known inhibitors with a triazole-phenol scaffold. The observed structure-activity relationships suggest that the triazole-phenol is a promising scaffold for systematic cycles of design and synthesis to further elucidate the structure activity relationships in MIF binding.