Miracle-dz/UniFAR-FTUs huggingface dataset:
Networking and Transportation Planning for Regional Synergism

The development of entities involves until to achieve the final results passing through the stages of association, organization, communication and fluxes of data. The vis-a-vis congruencies from the networking field context give birth to the ensuing sequence of the previous chained concepts. Herein, we highlight the networking role specifically by the equivalence between association with networking; organization with network's architecture; communication with linkages and fluxes of data with dynamics. In addition, from any external constructive appraisal it is desirable to give synergism to the previous sequence in order to get not only a result but an efficient result. Then, we set forth three case studies in order to analyze the contribution of networking in planning to improve regional synergism. The first case is the design of a binary associative network with SMEs respondents over firm attribute dichotomies which render the archetype pattern in the surveyed assembly. The second one deals with a horizontal network architecture, of n local SMEs which perform similar economic activity, in which different linkage strategies impose success or defeat to specific ensemble's aim. The third case concerns with the localization of soybean and/or wheat storing and processing plants in a heuristic interface in order to envisage real and objective planning decisions from an external appraisal in the regional logistic.
Pattern of formylmethionyl-leucyl-phenylalanine-induced luminol- and lucigenin-dependent chemiluminescence in human neutrophils

The stimulation of neutrophils by formylmethionyl-leucyl-phenylalanine results in a bimodal luminol-dependent chemiluminescence pattern. We observed, however, only a single peak chemiluminescence pattern in the response to the peptide when we used lucigenin as an amplifying substance. We suggest that lucigenin, the larger molecule, (510 daltons; luminol is 177 daltons) only exerts an extracellular effect.
Factors Associated with Low Bone Density among Women with Major Depressive Disorder

Objective: Previous studies have suggested that depression might be associated with low bone mineral density (BMD) in women with depression. The aim of this study was to investigate the association between the BMD of women with major depressive disorder and correlated factors. Method: This prospective cross-sectional study explored the association between bone density and major depressive disorder in women. One hundred women diagnosed with major depressive disorder were enrolled. The diagnoses were made by board-certificated psychiatrists using the Mini International Neuropsychiatric Interview (MINI). The Beck Depression Inventory (BDI) was administered. The bone density of the hip was measured with dual X-ray densitometry (DEXA) using a Hologic Delphi QDR-2000 densitometer. Results: We found age, family history of osteoporosis, consumption of coffee, and consumption of tea to be associated with low BMD in single-variate analysis. Depression was also related to BMD, in that the worse the depression, the lower the BMD. Multi-variate analysis by linear regression revealed an equation of BMD = 0.91 − 0.004 × (severity of depression) + 0.07 × (tea consumption) − 0.06 × (family history of osteoporosis) − 0.04 × age. Conclusion: These results suggest that depression is associated with lower BMD, and the associated factors should be considered in depressive women. The findings of this research may be useful for improving the care of women with major depressive disorder in terms of developing appropriate and effective care plans.
The Hidden Benefits of Non-Elite Mass Participation Sports Events: An Economic Perspective

This paper examines the hidden financial benefits that non-elite events are capable of delivering for host cities. The paper provides examples of how mass participation (and other non-elite) events can generate substantial economic impacts comparable to and, in some cases greater than, those associated with elite events. Cost-effectiveness of mass participation events, relative to major elite sports events, is discussed.
Mesenchymal Progenitor Cells: Tissue Origin, Isolation And Culture

Since the pioneering work of Alexander Friedenstein on multipotent mesenchymal stromal cells (MSCs), a tremendous amount of work has been done to isolate, characterize and culture such cells. Assay of colony forming unit-fibroblasts (CFU-Fs), the hallmark of MSCs, is used to estimate their frequency in tissue. MSCs are adherent cells, so they are easy to isolate, and they show contact inhibition. Thus, several parameters must be taken into account for culture: cell density, number of passages, culture medium, and growth factors used. The purity of the initial material is not a limiting parameter. Similar but not identical cell populations are found in almost all mammal or human tissues. MSCs seem to be very abundant in adipose tissue but at low frequency in blood from umbilical cord or in adult tissue. The culture conditions are very similar, whatever the source of cells. Because of their favorable properties, MSCs are very promising tools for regenerative medicine.
Results with EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) chemotherapy in gestational trophoblastic neoplasia

The aim of this study was to evaluate the efficacy and toxicity of EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) regimen for the treatment of high-risk gestational trophoblastic neoplasia (GTN). Thirty-three patients with high-risk GTN, scored according to World Health Organization, received 159 EMA/CO treatment cycles between 1994 and 2004. Twenty-three patients were treated primarily with EMA/CO, and 10 patients were treated secondarily after failure of single agent or MAC (methotrexate, actinomycin D, cyclophosphamide, or clorambucile) III chemotherapy. Adjuvant surgery and radiotherapy were used in selected patients. Survival, response, and toxicity were analyzed retrospectively. The overall survival rate was 90.9% (30/33). Survival rates were 91.3% (21/23) for primary treatment and 90% (9/10) for secondary treatment. Six (18.2%) of 33 patients had drug resistance. Four of them underwent surgery for adjuvant therapy. Three of these patients with drug resistance died. Survival and complete response to EMA/CO were influenced by liver metastasis, antecedent pregnancy, and histopathologic diagnosis of choriocarcinoma. Survival rate was also affected by blood group. The treatment was well tolerated. The most severe toxicity was grade 3–4 leukopenia that occurred in 24.3% (8/33) of patients and 6.9% (11/159) of treatment cycles. Febrile neutropenia occurred in one patient (3%). EMA/CO regimen is highly effective for treatment of high-risk GTN. Its toxicity is well tolerated.
Effect of roasting on site and extent of digestion of soybean meal by sheep: I. Digestion of nitrogen and amino acids.

Six mature wethers (BW 72 kg) with ruminal, duodenal, and ileal cannulas were fed a control (no added soybean meal [SBM]) diet or diets containing unheated SBM or SBM roasted at 165 degrees C for 75, 150, 180, or 210 min in a 6 x 6 Latin square experiment. Concentrations of indicators of heat exposure (ADIN, ADF, NDF) in SBM increased with increasing roasting time. Duodenal flows of total N, non-bacterial N, and SBM N increased (P < .05) linearly with increased roasting time. Small intestinal (SI) digestibility (percentage entering SI) of total N and SBM N was influenced quadratically (P < .05) by roasting time; SI digestibilities were modestly increased by heating SBM to 150 min, then declined dramatically when SBM was heated for 180 and 210 min. These responses resulted in a quadratic (P < .05) increase in quantity of total and SBM N disappearing in the SI; quantities increased as SBM was heated to 150 min and remained unchanged when SBM was heated for 180 and 210 min. These responses resulted in a quadratic (P < .05) increase in quantity of total and SBM N disappearing in the SI; quantities increased as SBM was heated to 150 min and remained unchanged when SBM was heated for 180 and 210 min. Duodenal flows and SI digestibilities of total and non-bacterial amino acids (AA) and of most individual AA followed patterns similar to those observed for N. Maximum quantities of total and individual AA disappeared from the SI when wethers were fed SBM roasted at 165 degrees C for 150 min. Evaluation of the effects of heat treatment on the nutritive value of a protein source for ruminants should include considerations for both ruminal protein escape and SI availability of escaped protein and for the nature of the AA supply absorbed from the SI.
Dynamics and fate of natural and waste organic material in soils: the role of the soil organic matter (SOM) recalcitrance in SOM turnover.

Previous studies suggested that micropore surface area (MiS) of bio-macromolecules of biomass constitutes an important factor that explains their preservation in soil, that is, the preservation against biological degradation. On the other hand it has been reported that biochemical catalysis are limited in theirs action by the very complex macroscopic and microscopic structure of cell walls that limit mass transportation. Results of this work indicated the structure (nanostructure) of the cell wall playing a main role in the preservation of the organic matter in soil. Total microporosity and pore dimension correlated with biomass degradation. On the other hand chemical composition determined by CPMAS 13- NMR does not play a role in the definition of biomass recalcitrance.
Demand and Marketing Study at Army Corps of Engineers Day-Use Areas

Abstract : Increasing use of fees to offset declining appropriations has been an ongoing reality for the past 10 years. There are few studies that attempt to gather the impact this has on the users at Corps projects. This study developed marketing and demand information along with attitudinal measures related to fees for Corps day-use facilities (picnic areas, beaches, and boat ramps) from six Corps projects in different parts of the country. Revenue projections and fee impacts on population subgroups along with respondent motivations, attitudes, and expectations towards fees are provided along with recommendations concerning the implementation and level of fee for day-use facilities. Attitudes, Motivations, Perceptions, Fees, Outdoor recreation, Revenue. Marketing and demand studies,
Identification of Novel Mycobacterium bovis Antigens by Dissection of Crude Protein Fractions

ABSTRACT Culture filtrate and cell extracts from Mycobacterium bovis cultures contain molecules which could promote protective immunity to tuberculosis in animals. Different protein fractions of M. bovis cultures were obtained by elution electrophoresis and were tested in experimentally infected cattle. The fractions that elicited gamma interferon (IFN-γ) responses were resolved by two-dimensional gel electrophoresis, and individual proteins were identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry. The open reading frames were cloned, expressed as their recombinant forms, and retested with naturally and experimentally infected animals. Eleven protein fractions were highly reactive, from which the Rv1636, HspX, Rv0138, Rv2524, EsxI, and Rv3740 recombinant proteins were obtained. EsxI and HspX were the antigens most recognized by the IFN-γ release assay. In summary, a proteomic approach allowed the identification of novel antigens useful for the diagnosis of bovine tuberculosis.
Three-Manifolds Having Complexity At Most 9

We describe an algorithm which has enabled us to give a complete list, without repetitions, of all closed oriented irreducible three-manifolds of complexity up to 9. More interestingly, we have actually been able to give a name to each such manifold, by recognizing its canonical decomposition into Seifert fibered spaces and hyperbolic manifolds. The algorithm relies on the extension of Matveev's theory of complexity to the caseof manifolds bounded by suitably marked tori, and on the notion of assembling of two such manifolds. We show that every manifold is an assembling of manifolds which cannot be further disassembled, and we prove that there are surprisingly few such manifolds up to complexity 9. Our most interesting experimental discovery is that there are 4 closed hyperbolic manifolds having complexity 9, and they are the 4 closed hyperbolic manifolds of least known volume. All other manifolds having complexity at most 9 are graph manifolds.
Efficacy of the Atkins diet as therapy for intractable epilepsy

The ketogenic diet is effective for treating seizures in children with epilepsy. The Atkins diet can also induce a ketotic state, but has fewer protein and caloric restrictions, and has been used safely by millions of people worldwide for weight reduction. Six patients, aged 7 to 52 years, were started on the Atkins diet for the treatment of intractable focal and multifocal epilepsy. Five patients maintained moderate to large ketosis for periods of 6 weeks to 24 months; three patients had seizure reduction and were able to reduce antiepileptic medications. This provides preliminary evidence that the Atkins diet may have a role as therapy for patients with medically resistant epilepsy.
Prognostic factors for tumor response and limb recurrence-free interval in patients with advanced melanoma of the limbs treated with regional isolated perfusion with melphalan.

BACKGROUND At this time little is known about prognostic factors for tumor response and subsequent limb recurrence-free interval in patients suffering from advanced melanoma of the limbs who were treated with regional isolated perfusion. METHODS A retrospective analysis was done, with a logistic regression model and a Cox proportional hazard analysis, looking at possible patient-, tumor-, and treatment-related prognostic factors in all 120 patients with advanced melanoma of the limbs who were treated with regional isolated perfusion with melphalan in the period 1978 to 1990 at our institutions. RESULTS Complete remission was achieved in 65 patients (54%) with a median duration of 9+ months (range, 1 to 97+ months), and partial remission was seen in 30 patients (25%). Prognostic factors for complete remission were multiple versus single perfusion schedule, the absence of regional node involvement, and leg versus other tumor sites. The 3-year limb recurrence-free interval was 38%. Factors associated with this interval were one as opposed to more than one lesion, complete remission after perfusion, and female sex. Patients exhibiting complete remission after perfusion had a better overall 3-year survival rate than had patients without complete remission (60% vs 35%; p = 0.0012). CONCLUSIONS In the present study prognostic factors for tumor response and limb recurrence-free interval could be determined. A multiple perfusion schedule may be more effective in providing complete remission in patients undergoing regional isolated perfusion than single perfusions are.
Addressing the Immunogenicity of the Cargo and of the Targeting Antibodies with a Focus on Deimmunized Bacterial Toxins and on Antibody-Targeted Human Effector Proteins

Third-generation immunotoxins are composed of a human, or humanized, targeting moiety, usually a monoclonal antibody or an antibody fragment, and a non-human effector molecule. Due to the non-human origin of the cytotoxic domain, these molecules stimulate potent anti-drug immune responses, which limit treatment options. Efforts are made to deimmunize such immunotoxins or to combine treatment with immunosuppression. An alternative approach is using the so-called “human cytotoxic fusion proteins”, in which antibodies are used to target human effector proteins. Here, we present three relevant approaches for reducing the immunogenicity of antibody-targeted protein therapeutics: (1) reducing the immunogenicity of the bacterial toxin, (2) fusing human cytokines to antibodies to generate immunocytokines and (3) addressing the immunogenicity of the targeting antibodies.
Low back pain and sciatica: summary of NICE guidance

#### What you need to know Low back pain is the leading cause of long term disability worldwide.1 The lifetime incidence of low back pain is 58-84%,2 and 11% of men and 16% of women have chronic low back pain.3 Back pain accounts for 7% of GP consultations and results in the loss of 4.1 million working days a year.2 More than 30% of people still have clinically significant symptoms after a year after onset of sciatica.4 This guideline replaces the National Institute for Health and Care Excellence (NICE) guideline on early management of low back pain in adults (2009) and expands its remit. It summarises the updated recommendations from NICE for the assessment and management of low back pain and sciatica.5 For a visual summary, please see infographic. It is intended to overcome patchy commissioning of back pain pathways and pain management programmes6 and poor implementation due to clinicians’ beliefs that previous recommendations were constraining clinical practice.7 NICE recommendations are based on systematic reviews of best available evidence and explicit consideration of cost effectiveness. When minimal evidence …
Research in mobile database query optimization and processing

The emergence of mobile computing provides the ability to access information at any time and place. However, as mobile computing environments have inherent factors like power, storage, asymmetric communication cost, and bandwidth limitations, efficient query processing and minimum query response time are definitely of great interest. This survey groups a variety of query optimization and processing mechanisms in mobile databases into two main categories, namely: (i) query processing strategy, and (ii) caching management strategy. Query processing includes both pull and push operations (broadcast mechanisms). We further classify push operation into on-demand broadcast and periodic broadcast. Push operation (on-demand broadcast) relates to designing techniques that enable the server to accommodate multiple requests so that the request can be processed efficiently. Push operation (periodic broadcast) corresponds to data dissemination strategies. In this scheme, several techniques to improve the query performance by broadcasting data to a population of mobile users are described. A caching management strategy defines a number of methods for maintaining cached data items in clients' local storage. This strategy considers critical caching issues such as caching granularity, caching coherence strategy and caching replacement policy. Finally, this survey concludes with several open issues relating to mobile query optimization and processing strategy.
Telemedicine in the future

summary Telemedicine can provide a compelling alternative to conventional acute, chronic and preventive care, and can improve clinical outcomes. In the industrialized world, it is likely that telemedicine will continue to move healthcare delivery from the hospital or clinic into the home. In the developing world or in regions with limited infrastructure, telemedicine will mainly be used in applications that link providers based at health centres, referral hospitals and tertiary centres. The future of telemedicine will depend on: (1) human factors, (2) economics and (3) technology. Behaviours related to technology affect change at the individual, organizational and societal level. Personnel shortages and decreasing third-party reimbursement are significant drivers of technology-enabled health care in the industrialized world, particularly in the areas of home care and self-care. We can safely assume that developments in mobile communications, sensor devices and nanotechnology will alter the way that health care is delivered in the future. The growth and integration of information and communication technologies into health-care delivery holds great potential for patients, providers and payers in health systems of the future. Perhaps the most difficult question to answer, however, is ‘When will telemedicine become part of the standard of care? ’
Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding

We have investigated the molecular basis of biological differences observed among cell line-adapted isolates of the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and the simian immunodeficiency virus (SIV) in response to receptor binding by using a soluble form of CD4 (sCD4) as a receptor mimic. We find that sCD4 binds to the envelope glycoproteins of all of the HIV-1 isolates tested with affinities within a threefold range, whereas those of the HIV-2 and SIV isolates have relative affinities for sCD4 two- to eightfold lower than those of HIV-1. Treatment of infected cells with sCD4 induced the dissociation of gp120 from gp41 and increased the exposure of a cryptic gp41 epitope on all of the HIV-1 isolates. By contrast, neither dissociation of the outer envelope glycoprotein nor increased exposure of the transmembrane glycoprotein was observed when sCD4 bound to HIV-2- or SIV-infected cells. Moreover, immunoprecipitation with sCD4 resulted in the coprecipitation of the surface and transmembrane glycoproteins from virions of the HIV-2 and SIV isolates, whereas the surface envelope glycoprotein alone was precipitated from HIV-1. However, treatment of HIV-1-, HIV-2-, and SIV-infected cells with sCD4 did result in an increase in exposure of their V2 and V3 loops, as detected by enhanced antibody reactivity. This demonstrates that receptor binding to the outer envelope glycoprotein induces certain conformational changes which are common to all of these viruses and others which are restricted to cell line-passaged isolates of HIV-1.
Intermodulation harvesting rectifier design for high efficiency multi-sine wireless power transfer

This paper presents an intermodulation harvesting rectifier design for multi-sine wireless power transfer (WPT). It provides a practical solution to reduce the output ripple in multi-sine WPT as well as a substantial efficiency improvement. The mechanism analysis of multi-sine WPT is presented and the Intermodulation harvesting rectifier circuit is accordingly designed to improve power transmission performance. Measured results show that the multi-sine WPT with the proposed rectifier could achieve both a 10% efficiency improvement from traditional WPT systems and a stable DC output with less ripple. It provides a good reference when designing a stable high efficiency WPT system.
Derivative-free restricted maximum likelihood estimation in animal models with a sparse matrix solver.

Estimation of (co)variance components by derivative-free REML requires repeated evaluation of the log-likelihood function of the data. Gaussian elimination of the augmented mixed model coefficient matrix is often used to evaluate the likelihood function, but it can be costly for animal models with large coefficient matrices. This study investigated the use of a direct sparse matrix solver to obtain the log-likelihood function. The sparse matrix package SPARSPAK was used to reorder the mixed model equations once and then repeatedly to solve the equations by Cholesky factorization to generate the terms required to calculate the likelihood. The animal model used for comparison contained 19 fixed levels, 470 maternal permanent environmental effects, and 1586 direct and 1586 maternal genetic effects, resulting in a coefficient matrix of order 3661 with . 3% nonzero elements after including numerator relationships. Compared with estimation via Gaussian elimination of the unordered system, utilization of SPARSPAK required 605 and 240 times less central processing unit time on mainframes and personal computers, respectively. The SPARSPAK package also required less memory and provided solutions for all effects in the model.