Miracle-dz/UniFAR-FTUs huggingface dataset:
PC61 (Anti-CD25) Treatment Inhibits Influenza A Virus-Expanded Regulatory T Cells and Severe Lung Pathology during a Subsequent Heterologous Lymphocytic Choriomeningitis Virus Infection

ABSTRACT Prior immunity to influenza A virus (IAV) in mice changes the outcome to a subsequent lymphocytic choriomeningitis virus (LCMV) infection and can result in severe lung pathology, similar to that observed in patients that died of the 1918 H1N1 pandemic. This pathology is induced by IAV-specific memory CD8+ T cells cross-reactive with LCMV. Here, we discovered that IAV-immune mice have enhanced CD4+ Foxp3+ T-regulatory (Treg) cells in their lungs, leading us to question whether a modulation in the normal balance of Treg and effector T-cell responses also contributes to enhancing lung pathology upon LCMV infection of IAV-immune mice. Treg cell and interleukin-10 (IL-10) levels remained elevated in the lungs and mediastinal lymph nodes (mLNs) throughout the acute LCMV response of IAV-immune mice. PC61 treatment, used to decrease Treg cell levels, did not change LCMV titers but resulted in a surprising decrease in lung pathology upon LCMV infection in IAV-immune but not in naive mice. Associated with this decrease in pathology was a retention of Treg in the mLN and an unexpected partial clonal exhaustion of LCMV-specific CD8+ T-cell responses only in IAV-immune mice. PC61 treatment did not affect cross-reactive memory CD8+ T-cell proliferation. These results suggest that in the absence of IAV-expanded Treg cells and in the presence of cross-reactive memory, the LCMV-specific response was overstimulated and became partially exhausted, resulting in a decreased effector response. These studies suggest that Treg cells generated during past infections can influence the characteristics of effector T-cell responses and immunopathology during subsequent heterologous infections. Thus, in humans with complex infection histories, PC61 treatment may lead to unexpected results.
Efectos de la proteína de soja aislada sobre la hipertensión y el alterado metabolismo de la glucosa en musculo cardíaco de ratas dislipemicas insulino resistentes.

El objetivo del trabajo fue analizar los efectos de la administracion de proteina de soja aislada, sobre la hipertension y alteraciones del metabolismo de la glucosa presentes en el musculo cardiaco de ratas dislipemicas insulino resistentes, inducidas por una ingesta cronica de una dieta rica en sacarosa (DRS). Ratas machos Wistar recibieron durante 4 meses DRS. Finalizado este periodo, la mitad de los animales continuo con la DRS y en la otra mitad la proteina de soja aislada sustituyo a la caseina como fuente proteica (DRS+PS) durante 4 meses adicionales. El grupo control (DC) consumio dieta control durante toda la experiencia. Los resultados alcanzados demuestran que esta manipulacion dietaria fue capaz de revertir la hipertension arterial normalizando la alterada fosforilacion de la glucosa –estimada por la actividad hexoquinasa- y el contenido de glucosa-6-fosfato y glucogeno en el musculo cardiaco. La sustitucion de caseina por proteina de soja como fuente proteica normalizo los niveles plasmaticos de trigliceridos, acidos grasos no esterificados y la moderada hiperglucemia sin cambios en la insulinemia. La sensibilidad insulinica periferica global mejoro notablemente aunque sin alcanzar valores del grupo DC. Los resultados obtenidos muestran a la proteina de soja dietaria como una herramienta nutricional capaz de normalizar la presion arterial, la fosforilacion y la via no oxidativa de la glucosa en el musculo cardiaco en este modelo experimental.
Cell Death and Anti-DNA Antibodies

Autoantibodies are characteristic features of autoimmune diseases (Table 1). In organ or tissue-specific autoimmune diseases, autoantibodies against cell-surface molecules are usually observed. These antibodies (Abs) stimulate or damage the target cells and cause organor tissue-specific diseases. In systemic autoimmune diseases, in addition to anti-cellsurface molecule Abs, Abs against intracellular molecules are frequently observed although B cell tolerance to intracellular molecules is strictly enforced in normal subjects. Some indicate high disease specificity with a high incidence rate. Therefore, such Abs may be closely associated with development of the disease as well as with disease activity. However, it is not known how or why Abs against intracellular molecules are generated.
Does direct transport to provincial burn centres improve outcomes? A spatial epidemiology of severe burn injury in British Columbia, 2001-2006.

BACKGROUND In Canada and the United States, research has shown that injured patients initially treated at smaller emergency departments before transfer to larger regional facilities are more likely to require longer stays in hospital or suffer greater mortality. It remains unknown whether transport status is an independent predictor of adverse health events among persons requiring care from provincial burn centres. METHODS We obtained case records from the British Columbia Trauma Registry for adult patients (age ≥ 18 yr) referred or transported directly to the Vancouver General Hospital and Royal Jubilee Hospital burn centres between Jan. 1, 2001, and Mar. 31, 2006. Prehospital and in-transit deaths and deaths in other facilities were identified using the provincial Coroner Service database. Place of injury was identified through data linkage with census records. We performed bivariate analysis for continuous and discrete variables. Relative risk (RR) of prehospital and in-hospital mortality and hospital stay by transport status were analyzed using a Poisson regression model. RESULTS After controlling for patient and injury characteristics, indirect referral did not influence RR of in-facility death (RR 1.32, 95% confidence interval [CI] 0.54- 3.22) or hospital stay (RR 0.96, 95% CI 0.65-1.42). Rural populations experienced an increased risk of total mortality (RR 1.22, 95% CI 1.00-1.48). CONCLUSION Transfer status is not a significant indicator of RR of death or hospital stay among patients who received care at primary care facilities before transport to regional burn centres. However, significant differences in prehospital mortality show that improvements in rural mortality can still be made.
Advanced Observations of Lightning Induced Voltage on Power Distribution Lines (II)

The authors discuss observations of induced voltages on the experimental overhead distribution line at a power plant facing the Japan Sea from October 1984 through March 1988. Waveforms of induced voltage from lightning strokes to a high stack of the power plant were measured simultaneously with the current waveforms of the lightning stroke to the stack. The polarity of lightning-induced voltage is opposite to that of lightning stroke current, regardless of the season. Except for unusual conditions, lightning induced voltages have a unipolar waveform. The lightning-induced voltage on the closest point of a distribution line to the lightning striking point is the maximum. The induced voltage waveforms generated on a distribution line were calculated by means of improved numerical analysis which took the height of the stack into consideration. The calculated results agree better with the measured waveforms than made those made by means of an earlier analysis method. It is clarified that bipolar induced voltages are not produced by usual lightning stroke currents. >
Acquisition, processing & autofocus issues of high resolution long range airborne synthetic aperture radar

Long range high resolution imaging from airborne SAR is a challenging task because the higher propagation losses are mitigated by higher transmitted power but also high gain (more directive) antenna. But as carrier aircraft is submitted to position and attitude random fluctuations due to air turbulence and pilot corrective manoeuvres, directive antenna requires two-axis steering for achieving illumination long enough for the required cross-range resolution (with highly directive antenna, spotlight or sliding spotlight imaging mode are mandatory).
UMTS Network Planning UsingGenetic Algorithms

The continuously growing of cellular net complexity, that followed the introduction of UMTS technology, has reduced the usefulness of traditional design tools, making them quite unworthy. The purpose of this paper is to illustrate a design tool for UMTS optimized net planning based on genetic algorithms. In particular, some utilities for 3G net designers, useful to respect important aspects (such as the environmental one) of the cellular net, are shown.
Traceable, group-oriented, signature scheme with multiple signing policies in group-based trust management

In a group-based trust management scheme, peers are partitioned into groups based on chosen characteristics, such as location and interest. The super peer (SP), who is responsible for the storage and distribution of reputation value, has an important role in group-based trust management. Thus, if the SP is a disguised or malicious peer, serious security problems could occur. To solve these security problems, the authors propose a traceable, group-oriented, signature scheme with multiple signing policies for trust management. The SP's signature is generated by a designated group called the signature group. In the authors scheme, peers in the signature group will decide whether to generate the signature for the SP based on the SP's reputation, meaning that attackers cannot forge a valid signature. In addition, an outsider also can trace the signers who were involved in generating the signature for reputation valuation.
Tipologia de inovação: um estudo empírico em um hospital universitário

800x600 Normal 0 21 false false false PT-BR X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:. 0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} A pesquisa teve como objetivo contribuir para o entendimento da inovacao no contexto hospitalar por meio da identificacao dos tipos de inovacoes realizadas em um hospital universitario. Sendo a inovacao provocada pela habilidade de fazer relacoes, de visualizar oportunidades, nas instituicoes hospitalares esta age como meio de melhorar a qualidade e seguranca dos servicos oferecidos para a populacao. Para alcancar o objetivo proposto, optou-se pela abordagem qualitativa de natureza exploratoria. Foram realizadas observacoes nao participantes, pesquisa a dados secundarios e entrevistas com os gestores do hospital procurando identificar suas percepcoes quanto as inovacoes realizadas . O estudo iniciou-se atraves de pesquisa bibliografica com base na literatura nacional e internacional referente ao tema inovacao, tipos de inovacao e inovacao em servicos. Apos o levantamento bibliografico foram realizadas as entrevistas com os gestores do hospital, por meio de um roteiro semiestruturado. O resultado da pesquisa mostrou uma forte relacao entre inovacoes em servicos e inovacoes em processo, sugerindo que inovacoes em servico, necessitam de inovacoes em processos para serem implementadas.
Complexity of Nonlinear Two-Point Boundary-Value Problems

We study upper and lower bounds on the worst-case e-complexity of nonlinear two-point boundary-value problems. We deal with general systems of equations with general nonlinear boundary conditions, as well as with second-order scalar problems. Two types of information are considered: standard information defined by the values or partial derivatives of the right-hand-side function, and linear information defined by arbitrary linear functionals. The complexity depends significantly on the problem being solved and on the type of information allowed. We define algorithms based on standard or linear information, using perturbed Newton's iteration, which provide upper bounds on the e-complexity. The upper and lower bounds obtained differ by a factor of log log 1/e. Neglecting this factor, for general problems the e-complexity for the right-hand-side functions having r (r ≥ 2) continuous bounded partial derivatives turns out to be of order (1/e)1/r for standard information, and (1/e)1/(r+1) for linear information. For second-order scalar problems, linear information is even more powerful. The e-complexity in this case is shown to be of order (1/e)1/(r-2), while for standard information it remains at the same level as in the general case.
Pilates Based Exercise in Muscle Disbalances Prevention and Treatment of Sports Injuries

The Pilates method has today become more popular than ever. As a form of movement it serves as a basis for fitness, complements sports training and is also one of the methods of physiotherapy. Pilates method combines features typical both for Eastern systems (mind control during exercises, relaxation, increasing of elasticity, movement starting from body center, balance) and Western systems (forming strength, endurance, exercises having both global and local effects). The primary goals in muscle-strain rehabilitation include not only recovery of muscle strength and flexibility but also correction of muscle imbalances. In prevention of sports injuries complementary training regarding body awareness, economical breathing, neuromuscular coordination by executing fluent and precise movement starting from a strong core is suggested. The Pilates based exercise, performed under the supervision of a certified instructor serve these needs and can be part of prophylaxis and kinesitherapy in sport medicine.
Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study

Attention‐deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co‐morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADHD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis‐free analysis of the GAIN–ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family‐Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 autosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that may be important in ADHD and ADHD‐related traits, such as conduct problems. We did not find genome‐wide statistical significance (P < 5 × 10−7) for any of the tested markers and the three conduct problem traits. Fifty‐four markers reached strong GWA signals (P < 10−5). We discuss these findings in the context of putative candidate genes and the implications of these findings in the understanding of the etiology of ADHD + CD. We aimed to achieve insight into the genetic etiology of a trait using a hypothesis‐free study design and were able to identify a number of biologically interesting markers and genes for follow‐up studies. © 2008 Wiley‐Liss, Inc.
Statistical Study of Voltage Fluctuations in Power Connectors During Fretting Vibration

It is well known that vibration of contact interfaces is the main cause of contact degradation by the so called fretting corrosion phenomenon. In fact the process of generating particles by mechanical wear produces an increase of contact voltage, frequently manifested by a high contact resistance in low power and signal connectors. In high power connectors, this degradation is expected to be accentuated by thermal effects generated by increasing the contact voltage up to melting and arcing voltages. The main objective of this work is to examine conjointly the electrical behavior and amount of wear of a connector terminal under vibration and higher current stress. In order to reproduce harsh vibration conditions, spring with lamella shape from an automotive connector, made from a copper alloy and coated with 2 mum of tin, are submitted to a high number of oscillations (103 to 106) where the pin is firmly attached to a fixed support. High frequency oscillations (100 Hz) with an amplitude of 50 mum is used. The contact is inserted into a resistive circuit supplied by 20 V and 3 A. The contact voltage is measured with a fast sampling oscilloscope and the voltage histogram is built up in real time. The losses of mass in the erosion track are evaluated by micro weighing. The main results show that at the low level of wear observed during the earlier stage of fretting, the contact voltage corresponds to pure constriction voltage < 20 mV. However, after this initiation period as the wear is increased, the contact voltage is increased and reaches a few hundred millivolts (melting and fritting voltage). Finally in last stage of degradation, an arcing voltage due to bounce phenomena is detected. These short arcs, observed for the first time in fretting under power, could accentuate the wear and the degradation process by erosion and mass transfer.
Neutral and acidic antitumor polysaccharides extracted from cultured fruit bodies of Grifola frondosa.

Water-soluble glucan fractions extracted from the cultured fruit bodies of Grifola frondosa with hot water, and with cold and hot sodium hydroxide containing urea showed potent antitumor activity in mice (Ohno et al., Chem. Pharm. Bull., 32, 1142 (1984)). Each fraction was separated into neutral and acidic glucan fractions on a DEAE-Sephadex A-25 (HCO3-) column. Both neutral and acidic fractions showed potent antitumor activity against Sarcoma 180 solid tumor in ICR mice. From the results of methylation analysis and carbon-13 nuclear magnetic resonance spectroscopy, the neutral fractions contained mainly α-1, 4 and 6-branched β-1, 3 linkages, and the acidic fractions contained mainly β-1, 6-and 6-branched β-1, 3 linkages. The branching ratio was similar in both glucans. By colorimetric analysis, each acidic fraction was found to contain about 2-5% uronic acid. These findings indicated that the cultured fruit bodies of Grifola frondosa contain neutral and acidic antitumor glucans.
Intoxicated Eyewitnesses: The Effects of Alcohol on Eyewitness Recall across Repeated Interviews

The study evaluated the usefulness of repeat-interviewing of witnesses to crimes who were intoxicated by alcohol at the time of the incident and their first interview, and then re-interviewed when not intoxicated the following day. Sixty young, social drinkers were divided into three groups. One group was given a “placebo” (alcohol-like) beverage, a second was given a “low dose” of alcohol (0.2 g/kg men; 0.17 g/kg women), and a third was given a “high dose” of alcohol (0.6 g/kg men; 0.52 g/kg women) over a 15 minute period. Twenty minutes later they viewed a 4-minute video of a crime, and afterwards they were given two opportunities to recall everything that they could remember from the incident; the first opportunity was immediately after the event, and the second was 24 hours later. Analyses of the quantity and accuracy of the details recalled revealed no overall increase in the total amount of information recalled between the first and second recall opportunities. However, on average, 18% of the details recalled by participants in the second test were new and accurate. The incidence of contradictions between the first and second recall opportunities was less than 1%. Surprisingly, none of the effects were influenced by alcohol, even at the highest dose. The results imply that 1) memory for at least some incidents observed under the influence of alcohol is resilient even up to relatively high blood-alcohol levels; and 2) the repeated interviewing of witnesses who were intoxicated at the time of the crime can reveal additional, reliable information that is not present at the initial interview, just as is the case for non-intoxicated witnesses.
An outbreak of norovirus infection associated with fermented oyster consumption in South Korea, 2013

SUMMARY An acute gastroenteritis (AGE) outbreak was reported in May 2013 in Gyeonggi Province, South Korea. Eight students who had eaten breakfast on 21 May 2013 at a high-school restaurant exhibited AGE symptoms. Our case-control study showed that a strong association was observed between AGE symptoms and fermented oyster consumption. Virological studies also indicated that noroviruses (NoVs) were detected from both clinical samples and fermented oyster samples, and multiple different genotypes (genogroups GII.4, GII.11 and GII.14) of NoVs were present in both samples. The nucleotide sequence similarity between the strains found in the clinical samples and those in the fermented oysters was more than 99·5%. Therefore, to prevent further outbreaks, proper management of raw oysters is necessary and the food industry should be aware of the risk of viral gastroenteritis posed by fermented oysters contaminated with NoVs.
Tolerance defects in New Zealand Black and New Zealand Black X New Zealand White F1 mice.

The susceptibility of autoimmune NZB and (NZB X NZW)F1 mice to the induction of tolerance by monomeric BSA was compared with several normal mouse strains. Unresponsiveness in T and B lymphocyte compartments was probed by challenging with DNP8BSA and measuring anti-DNP and anti-BSA antibodies separately. Tolerance induced by monomeric BSA was carrier specific, and there was no evidence of epitope-specific suppression. Normal NZW, NFS, and B10.D2 mice were easily rendered tolerant with monomeric BSA and did not produce anti-DNP or anti-BSA antibodies after challenge with DNP8BSA. By contrast, the lack of anti-DNP antibody response in similarly treated NZB mice was dependent on the dose of monomeric BSA, indicating that the helper T cells were partially resistant to tolerance induction. NZB mice treated with a high dose of monomeric BSA produced anti-BSA, but not anti-DNP, antibodies after immunization. Thus, the anti-carrier B cells in NZB mice may have been primed by monomeric BSA. The presence of the xid gene on the NZB background rendered the mice susceptible to induction of tolerance, suggesting that the tolerance defect in NZB mice involves the B cell compartment. This abnormal antibody response was a dominant trait: (NZB X NFS)F1 and (NZB X B10.D2)F1 mice had the same characteristics as NZB mice. These F1 hybrids do not develop autoimmune disease, indicating that resistance to experimental tolerance induction expressed at a B cell level may not be sufficient for disease development. In contrast to NZB and other NZB F1 hybrids, (NZB X NZW)F1 hybrids treated with monomeric BSA and challenged with DNP8BSA responded to both DNP and BSA. The contribution of a B cell defect to the tolerance abnormality of (NZB X NZW)F1 mice was examined by analyzing the effect of the xid gene on the progeny of (NZB.xid X NZW)F1 mice. Unlike the effect of the xid gene on NZB mice, both phenotypically normal heterozygous female and phenotypically xid hemizygous male mice produced anti-DNP and anti-BSA antibodies after tolerance induction and immunization, demonstrating that a major helper T cell abnormality was present in (NZB X NZW)F1 mice. The (NZW X B10.D2)F1 hybrid was rendered tolerant by this procedure, indicating that the helper T cell defect (NZB X NZW)F1 mice may have resulted from gene complementation with the NZB mice contributing partial resistance of T helper cells to tolerance induction. (ABSTRACT TRUNCATED AT 400 WORDS)