Miracle-dz/UniFAR-FTUs huggingface dataset:
Hemodynamic after-effects of acute dynamic exercise in sedentary normotensive postmenopausal women

Objectives To determine, in sedentary normotensive postmenopausal women, the after-effects of exercise on systemic and regional hemodynamics, and whether changes in total peripheral conductance after exercise relate to changes in brachial artery flow-mediated vasodilation (FMD). Methods In 13 sedentary postmenopausal women, the blood pressure (BP), cardiac output, total peripheral resistance and total peripheral conductance, calf vascular resistance and FMD were measured during baseline rest, and again commencing 45 min after treadmill exercise. Fourteen premenopausal women completed the identical protocol to obtain reference values for the after-effects of exercise in healthy females. Results In postmenopausal women, exercise was followed by falls in systolic BP (P < 0.01) and diastolic BP (P < 0.001). BP did not fall after exercise in premenopausal women. In both groups the cardiac output (P < 0.01) increased and the calf vascular resistance (P < 0.01) and total peripheral resistance (P < 0.05) decreased after exercise, but resistance fell more (P < 0.05) in postmenopausal women. Baseline FMD was greater in premenopausal women (12.1 ± 1.5 versus 5.3 ± 1.3%, P < 0.01), and similar before and after exercise, whereas prior exercise nearly doubled the FMD of postmenopausal women (to 9.9 ± 1.4%, P < 0.01). These increases in FMD correlated with baseline values (r = −0.75, P < 0.01) and with relative changes in total peripheral conductance (r = 0.72, P < 0.02). The latter relationship was absent in premenopausal women (r = −0.29). Conclusions In postmenopausal women, acute dynamic exercise elicits sustained increases in FMD that could facilitate post-exercise hypotension in this population. These observations reinforce the concept of exercise as an important non-pharmacological intervention to modify cardiovascular risk in postmenopausal women.
Awareness of Post – Exposure Prophylaxis Guidelines against Occupational Exposure to HIV Among Post Graduate Residents at Mangalore, India

A b s t r A c t Background: Health care workers (HCWs) are regularly exposed to blood, and other body fluids which make them prone to a risk of acquiring the infection. Despite following ‘universal precautions’, accidental exposure may occur while performing invasive procedures and handling high risk fluids. Objectives: (a) to assess the awareness of post exposure prophylaxis (PEP) in case of needle-stick injury from confirmed or suspected source of HIV amongst I-year postgraduate residents of Kasturba Medical college & Manipal college of Dental sciences, Mangalore, India. (b) to educate them about the post-exposure prophylaxis guidelines against occupational exposure to HIV. Methodology: this is a cross sectional study among 85 postgraduate residents based on response to structured questionnaire. results were analyzed and tabulated using national AID s control Organization guidelines as reference standard for comparison. Results: nineteen respondents (22%) were aware of the true risk of transmission. About half of the respondents identified all the high risk fluids correctly. Twenty-five respondents (29%) knew whom to contact immediately after accidental exposure while only 20respondents (23%) knew that washing with soap and water was the initial measure. though half of the respondents knew that prophylaxis should be initiated within 1hour of injury, a mere 30% knew the correct duration of P eP. 42% respondents were aware of the availability of drugs and only 28% knew the approximate cost of therapy. Conclusion: there is a considerable lack of awareness among the medical and dental postgraduate residents about the P eP against accidental exposure to HIV suggesting a need for training and awareness programmes to improve the awareness.
Clinical Features and Diagnosis of Spontaneous Intracerebral Hemorrhage

Background: Intracerebral hemorrhage (ICH) is the second most common type of stroke, trailing only ischemic stroke in frequency. There are many underlying pathological conditions associated with ICH; hypertension, amyloid angiopathy, ruptured saccular aneurysm, and vascular malformation account for the majority of cases. Initial goals of treatment include preventing hemorrhage extension, as well as the prevention and management of elevated intracranial pressure along with other neurologic and medical complications. Summary of review: Data were obtained from 21 studies conducted between 2000 to 2018 with title of Spontaneous intracerebral hemorrhage research articles were included in this review that we review clinical features and diagnosis of Spontaneous intracerebral hemorrhage. Conclusion: Hypertensive vasculopathy is the most common etiology of spontaneous intracerebral hemorrhage. Major risk factors for spontaneous ICH are hypertension, older age, the presence of cerebral amyloid angiopathy.
Near-field scattering enhancement of perylene based aggregates for random lasing

Strong near-field scattering enhancement (NFSE) of polyhedral oligomeric silsesquioxanes (POSS) nanoparticles (NPs) aggregates is found through physical simulation. An aggregation of N,N’-di-[3-(isobutyl polyhedral oligomeric silsesquioxanes) propyl] perylene diimide (DPP) which possesses POSS as scatteres experimentally performs strong NFSE, which confirms the physical simulation results. Moreover, coherent random laser is triggered from the DPP aggregates in carbon disulfide. It is the NFSE of POSS NPs connected to both ends of DPP through covalent bonds and the NFSE of their aggregation thanks to DPP’s aggregation that is responsible for the coherent random laser. So, this work develops a method to improve weak scattering of system through construction of molecules, and opens a road to a variety of novel interdisciplinary investigations, involving molecular designing for disordered photonics.Strong near-field scattering enhancement (NFSE) of polyhedral oligomeric silsesquioxanes (POSS) nanoparticles (NPs) aggregates is found through physical simulation. An aggregation of N,N’-di-[3-(isobutyl polyhedral oligomeric silsesquioxanes) propyl] perylene diimide (DPP) which possesses POSS as scatteres experimentally performs strong NFSE, which confirms the physical simulation results. Moreover, coherent random laser is triggered from the DPP aggregates in carbon disulfide. It is the NFSE of POSS NPs connected to both ends of DPP through covalent bonds and the NFSE of their aggregation thanks to DPP’s aggregation that is responsible for the coherent random laser. So, this work develops a method to improve weak scattering of system through construction of molecules, and opens a road to a variety of novel interdisciplinary investigations, involving molecular designing for disordered photonics.
Chemical Signal as a Rapid Long-Distance Information Messenger After Local Wounding of a Plant?

A series of works have described an important role of chemical signalling compounds in generation of the stress response of plants in both the wounded and distant undamaged plant tissues. However, pure chemical signals are often not considered in the fast (minutes) long-distance signalling (systemic response) because of their slow propagation speed. Physical signals (electrical and hydraulic) or a combination of the physical and chemical signals (hydraulic dispersal of solutes) have been proposed as possible linkers of the local wound and the rapid systemic response. We have recently demonstrated an evidence for involvement of chemical compounds (jasmonic and abscisic acids) in the rapid (within 1 hour) inhibition of photosynthetic rate and stomata conductance in distant undamaged tobacco leaves after local burning. The aim of this addendum is to discuss plausible mechanisms of a rapid long-distance chemical signalling and the putative interactions between the physical and chemical signals leading to the fast systemic response.
Crystal structure of a putative quorum sensing‐regulated protein (PA3611) from the Pseudomonas‐specific DUF4146 family

Pseudomonas aeruginosa is an opportunistic pathogen commonly found in humans and other organisms and is an important cause of infection especially in patients with compromised immune defense mechanisms. The PA3611 gene of P. aeruginosa PAO1 encodes a secreted protein of unknown function, which has been recently classified into a small Pseudomonas‐specific protein family called DUF4146. As part of our effort to extend structural coverage of novel protein space and provide a structure‐based functional insight into new protein families, we report the crystal structure of PA3611, the first structural representative of the DUF4146 protein family. Proteins 2014; 82:1086–1092. © 2013 Wiley Periodicals, Inc.
An efficient online anomalies detection mechanism for high-speed networks

In this paper, we propose an efficient framework for online detection and identification of network anomalies, in early stage of its occurrence, to quickly react by taking the appropriate countermeasures. The proposed framework is based on online detection of change point in a multi-layer reversible sketch, which aggregates multiple data streams from high speeds links in a stretched database. To detect network anomalies, we apply non-parametric multi-channel CUSUM algorithm at the counter value in each bucket of the proposed reversible sketch, in order to undermine flows with abrupt change, and to discover the keys of culprit flows via sketch inversion. Theoretical framework for detection and classification of attacks are presented. We also give the results of our experiments analysis at two data traces collected with Netflow and Endace DAG-3 card. Our analysis results from real-time internet traffic and online implementation show that our proposed architecture is able to detect culprit flows quickly with a high level of accuracy.
New therapeutic approaches Cardiac considerations in the treatment of the metabolic syndrome

To treat insulin resistance and avoid type 2 diabetes the condition must first be diagnosed. When diagnosed it can be assumed that with or without type 2 diabetes the insulin resistant subject has significant cardiovascular disease. Once diagnosed, aggressive therapy of insulin resistance and its associated risk factors has the potential to avoid cardiac events in both the diabetic and non-diabetic insulin resistant subjects. Treating insulin resistance can also avoid the development of diabetes and improve glycemic control and long-term complications in the established type 2 diabetic patient. Heart Metab. 2009;45:20–25.
Voltammetric Determination of Methadone at Stacked Cysteic Acid Film and Gold Nanoparticles Composite Modified Glassy Carbon Electrode

In this paper, a sensitive and convenient electrochemical sensor based on stacked cysteic acid film and gold nanoparticles (AuNPs) composite modified glassy carbon electrode (GCE) was developed for the determination of Methadone (MET). Electrochemical investigation of the modified electrode is achieved using cyclic voltammetry (CV), differential pulse voltammograms (DPV) and field emission scanning electron microscopy. The effective surface areas of AuNPs/cysteic acid/GCE increased for about 4-fold larger than that of the unmodified GCE. The kinetic parameters of the electron transfer coefficient (α) and number of electrons involved in the rate determining step (nα) for the oxidation of MET were determined utilizing CV. The designed modified electrode was revealed linear responses in the ranges of 0.024 to 4.45 μM and 4.45 to 12.67 μM with a limit of detection (LOD) of 0.014 μM (S/N=3). Excellent recovery results were obtained for determination of MET in spiked human blood plasma and urine samples at the modified electrode. KeywordsMethadone, Gold nanoparticles, Cysteic acid, Electrochemical sensor, Modified electrode
Chapter 2 Introduction : From Phase-Locked Loop to Costas Loop

The Costas loop can be considered an extended version of the phase-locked loop (PLL). The PLL has been invented in 1932 by French engineer Henri de Belleszice [1]. In his first application, de Belleszice used the PLL as a synchronous demodulator for double sideband amplitude modulated signals with carrier. The block diagram of a PLL is shown in Fig. 2.1. It is built from three blocks, a phase detector (PD), a loop filter (LF), and a voltage-controlled oscillator (VCO). In the first PLL applications, an analog multiplier was used for the phase detector [2]. Assuming for the first moment that both signals U1 and U2 are sinusoidal, we can write
Chapter 2 Static Magnetic Fields ( SMFs ) on Human Bodies

This chapter summarizes the effects of static magnetic fields (SMFs) on human bodies. Some commonly seen SMFs, such as the weak earth magnetic field that we are all exposed to, moderate to ultra-high field magnetic resonance imaging (MRI) in the hospitals and research institutes, as well as SMF-based magnetic therapies, which have a long history but still lack of solid explanation or sufficient experimentation from a scientific point of view. Magnetobiology and biomagnetism are also briefly discussed.
Tissue Renin—Angiotensin Systems: Fact or Fiction?

The discovery of the components of the renin-angiotensin system (RAS) in various tissues gave rise to the idea that functional “tissue” RASs exist that are more or less independent of the hormonal RAS. Further support for this notion came from the recent demonstration of the mRNA for the protein components of the RAS in a number of organs. Last but not least, the introduction of the converting-enzyme (CE) inhibitors, generating an enormous scientific interest in the role of the RAS, has contributed to the concept of “tissue” RASs, since some of the effects of these drugs were thought to be reconciled better with “tissue” than with plasma RAS inhibition. However, this model of plasma vs. “tissue” RAS still suffers from a number of conceptual problems. For instance, with respect to the “tissue” RAS in the vascular wall, it is not clear at present whether angiotensin-con-verting enzyme (ACE) is at all active inside endothelial cells. In addition, all evidence available speaks against its localization in the vascular media, while there may be some activity of the enzyme in the adventitial layer. Concerning the heart, there is at present no unequivocal evidence for a local angiotensin II (Ang II) production through ACE in cardiac tissue outside the coronary vessels. The localization of Ang II generation within tissue RASs in the adrenal gland or in the kidney, where Ang II may be generated through CE at the tubular brush border, are far from being elucidated. With some exceptions, such as the brain, the teslis, or tubular portions of the kidney, current evidence supports a model of endocrine vs. paracrine/autocrine RAS rather than “plasma” vs. “tissue” RAS. In the endocrine vs. paracrine/aulocrtne model, Ang II is always generated through ACE at the outer surface of endothelial cells, irrespective of whether its direct precursor, angiotensin I, is produced intracellularly in the vascular wall and secreted or produced in the circulating blood. Newly generated Ang II is endocrine when contributing to the circulating pool of Ang II, but is paracrine/autocrine when feeding back to adjacent cells (paracrine) or the same cell to which ACE is attached (autocrine). The endocrine RAS and the paracrine/autocrine RAS are thus intimately connected. Consequently, ACE inhibitors would always act upon ACE at the outer surface of the endotlhelium, i.e. they would nut have to penetrate into deeper tissue compartments to inhibit both endocrine and paracrine Ang II.
DAGC: Employing Dual Attention and Graph Convolution for Point Cloud based Place Recognition

Point cloud based retrieval for place recognition remains to be a problem demanding prompt solution due to its difficulty in efficiently encoding local features into adequate global descriptor in scenes. Existing studies solve this problem by generating a global descriptor for each point cloud, which is used to retrieve matched point cloud in database. But existing studies do not make effective use of the relationship between points and neglect different feature's discrimination power. In this paper, we propose to employ Dual Attention and Graph Convolution for point cloud based place recognition (DAGC) to solve these issues. Specifically, we employ two modules to help extract discriminative and generalizable features to describe a point cloud. We introduce a Dual Attention module to help distinguish task-relevant features and to utilize other points' different contributions to a point to generate representation. Meanwhile, we introduce a Residual Graph Convolution Network (ResGCN) module to aggregate local features of each point's multi-level neighbor points to further improve the representation. In this way, we improve the descriptor generation by considering the importance of both point and feature and leveraging point relationship. Experiments conducted on different datasets show that our work outperforms current approaches on all evaluation metrics.
Iterative Forward-Backward Pursuit Algorithm for Compressed Sensing

It has been shown that iterative reweighted strategies will often improve the performance of many sparse reconstruction algorithms. Iterative Framework for Sparse Reconstruction Algorithms (IFSRA) is a recently proposed method which iteratively enhances the performance of any given arbitrary sparse reconstruction algorithm. However, IFSRA assumes that the sparsity level is known. Forward-Backward Pursuit (FBP) algorithm is an iterative approach where each iteration consists of consecutive forward and backward stages. Based on the IFSRA, this paper proposes the Iterative Forward-Backward Pursuit (IFBP) algorithm, which applies the iterative reweighted strategies to FBP without the need for the sparsity level. By using an approximate iteration strategy, IFBP gradually iterates to approach the unknown signal. Finally, this paper demonstrates that IFBP significantly improves the reconstruction capability of the FBP algorithm, via simulations including recovery of random sparse signals with different nonzero coefficient distributions in addition to the recovery of a sparse image.
Coincidence-Anticipation Timing Requirements are Different in Racket Sports

The aim of this study was to compare the coincidence-anticipation timing accuracy of athletes of different racket sports with various stimulus velocity requirements. Ninety players (15 girls, 15 boys for each sport) from tennis (M age = 12.4 yr., SD = 1.4), badminton (M age = 12.5 yr., SD = 1.4), and table tennis (M age = 12.4 yr., SD = 1.2) participated in this study. Three different stimulus velocities, low, moderate, and high, were used to simulate the velocity requirements of these racket sports. Tennis players had higher accuracy when they performed under the low stimulus velocity compared to badminton and table tennis players. Badminton players performed better under the moderate speed comparing to tennis and table tennis players. Table tennis players had better performance than tennis and badminton players under the high stimulus velocity. Therefore, visual and motor systems of players from different racket sports may adapt to a stimulus velocity in coincidence-anticipation timing, which is specific to each type of racket sports.
Diabetes and risk of hearing impairment in adults: a meta-analysis.

CONTEXT Recently, several studies have investigated the relationship between diabetes and hearing impairment, but results were inconsistent. OBJECTIVE Our objective was to compare the prevalence of hearing impairment between diabetic and nondiabetic adults. DATA SOURCES We performed a systematic literature search using MEDLINE (1950 to May 30, 2011) and EMBASE (1974 to May 30, 2011). STUDY SELECTION Cross-sectional studies were included if data on numbers of hearing-impaired and non-hearing-impaired cases with diabetes were presented. Hearing impairment was limited to that assessed by pure-tone audiometry that included at least 2 kHz of frequency range and was defined as progressive, chronic, sensorineural, or without specified cause. DATA EXTRACTION Two authors independently extracted relevant data. Odd ratios (ORs) of hearing impairment related to diabetes calculated in each study were pooled with the random-effects model. DATA SYNTHESIS Data were obtained from 13 eligible studies (20,194 participants and 7,377 cases). Overall pooled OR (95% confidence interval) of hearing impairment for diabetic participants compared with nondiabetic participants was 2.15 (1.72-2.68). OR was higher in younger participants (mean age, ≤60 yr) than in those over 60 yr among which the OR remained significant (2.61 and 1.58, P = 0.008). The strength of the association between diabetes and prevalence of hearing impairment was not significantly influenced by whether participants were matched for age and gender (P = 0.68) or whether participants chronically exposed to noisy environments were excluded (P = 0.19). CONCLUSIONS Current meta-analysis suggests that the higher prevalence of hearing impairment in diabetic patients compared with nondiabetic patients was consistent regardless of age.
Prospective magnetic resonance imaging identification of focal cortical dysplasia, including the non—balloon cell subtype

The purpose of this study was to determine the role of high‐resolution T2‐weighted fast multiplanar inversion‐recovery (FMPIR) magnetic resonance (MR) imaging in detecting and delineating microscopic focal cortical dysplasia (FCD). We performed MR scans with FMPIR on 42 patients with suspected neocortical epilepsy. Ten MR studies were read prospectively as showing FCD; these case histories, electroencephalographic studies, and neuroimaging data were reviewed. Eight of these patients subsequently underwent focal cortical resection guided by intraoperative electrocorticography. The MR findings were correlated with pathological findings in these 8 patients. For purposes of radiological‐pathological correlation, the FCD lesions were divided into two classes. Radiological classification was based on the absence (type A) or presence (type B) of T2 prolongation of the subcortical white matter. Pathological grading as type I or type II was based on a previously described pathological grading system. Specific MR findings associated with FCD included focal blurring of the gray‐white matter interface (n = 9), thickening of the cortical ribbon (n = 7), and T2 prolongation of the subcortical white matter (n = 4). In 3 patients, the only MR finding that suggested FCD was localized blurring of the gray‐white matter junction. In 2 of these 3 patients, the MR diagnosis of FCD could be made only by FMPIR. FCD was confirmed histologically in 7 of 8 patients, with insufficient tissue for complete histopathological evaluation in 1 case. Radiological classification of FCD agreed with pathological classification in 5 of 7 cases. Correlation of MR findings with intraoperative electrocorticography results indicated that the MR study localized the epileptogenic lesion correctly in 8 of 8 cases. Scalp ictal electroencephalographic studies localized the epileptogenic lesion in 5 of 8 cases; positron emission tomographic scans were focally abnormal in 3 of 3 cases. FMPIR MR imaging permitted accurate diagnosis and localization of FCD in all patients with pathologically proved FCD. MR identification of FCD aided presurgical planning and intraoperative management of these patients.
FABRICATION AND MECHANICAL PROPERTIES OF ALUMINUM METAL MATRIX NANO COMPOSITE ( AL 6061 / CNT )

In this paper, Aluminum Metal Matrix Nano Composites (Al6061/CNT) are prepared using ultrasonic stir casting furnace by reinforcing different percentages of CNT 0.3%, 0.6% and 0.9% with the base material Aluminum Alloy 6061. The effects of different reinforcements on mechanical properties and internal structure of Aluminum Metal Matrix Nano Composites (AMMNCs) are studied. SEM Analysis of AMMNCs revealed the uniform distribution of Carbon Nano Tubes (CNT) in the Al6061 alloy. The considerable increase of Hardness and compressive strength at 0.3 wt. % and tensile strength at 0.6 wt. % are observed.