Miracle-dz/UniFAR-FTUs huggingface dataset:
Open Sharing of Data on Close Relationships and Other Sensitive Social Psychological Topics: Challenges, Tools, and Future Directions

This article reports on an adversarial (but friendly) collaboration examining the issues that lie at the intersection of confidentiality and open-data practices. We describe the process we followed to share our data for a speed-dating article we recently published in Psychological Science (Joel, Eastwick, & Finkel, 2017) and provide a summary of the issues we considered and addressed along the way. As we drafted the present article, the third author became unsure, in retrospect, about some of the procedures we had followed, especially if our approach were to be perceived as a model for open-data decisions in other, more typical cases involving nonindependent data. This article addresses these concerns, but also identifies areas of consensus. All three authors agree that there remains an unmet need for guidelines and other resources to help researchers address the challenges of sharing data that cover sensitive topics, particularly nonindependent data collected from pairs and groups (e.g., romantic couples, work teams, therapy groups). We conclude with a discussion of new tools that could be developed to help scholars who have collected such data to increase the transparency of their research while simultaneously protecting the confidentiality of the participants.
Attenuation of experimental subarachnoid hemorrhage-induced cerebral vasospasm by CGS 26303, an endothelin-converting enzyme inhibitor.

The effect of CGS 26303, an endothelin-converting enzyme inhibitor, on the prevention and reversal of cerebral vasospasm was investigated in a rabbit model of subarachnoid hemorrhage (SAH). In the prevention study, rabbits were injected with 3 ml of autologous blood in the cisterna magna and treatment with CGS 26303 i.v. was initiated 1 h later. The compound was subsequently administered at 12, 24, and 36 h post SAH and animals were sacrificed at 48 h post SAH. Treatment with CGS 26303 at 3, 10, and 30 mg/kg resulted in dose-dependent increases in the concentrations of the compound in cerebrospinal fluid samples, and the arterial narrowing after SAH was significantly attenuated in all three groups. Morphologically, corrugation of the internal elastic lamina of vessels was often observed in the vehicle-treated group, but it was not prominent in the CGS 26303-treated groups and the healthy controls. In the reversal study, treatment with CGS 26303 was initiated 24 h post SAH and a second injection was given 12 h later. Arterial narrowing was significantly attenuated in rabbits treated with CGS 26303 at 30 mg/kg. These results demonstrate that CGS 26303 may be an effective agent in prevention and reversal of cerebral vasospasm after aneurysmal SAH.
Effects of intraaccumbens administration of SCH‐23390 on cocaine‐induced locomotion and conditioned place preference

The effects of systemic (0–1.0 mg/kg) or intraaccumbens (0–1.0 μg/side) administration of SCH‐23390 on cocaine‐induced (0 or 4.2 mg/kg, IV) locomotion, sniffing, and conditioned place preference (CPP) were investigated in rats. After behavioral testing was completed, animals were injected with their respective dose of SCH‐23390 into the nucleus accumbens (NAc), followed by a systemic injection of the irreversible antagonist N‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ). Receptors occupied by intraaccumbens SCH‐23390, and therefore protected from EEDQ‐induced inactivation, were then quantified from autoradiograms of sections labeled with 3H‐SCH‐23390. Systemic administration of 0.5 and 1.0 mg/kg SCH‐23390 reversed cocaine‐induced locomotion, sniffing, and CPP, suggesting that stimulation of D1‐like receptors is necessary for these behavioral changes. Intraaccumbens administration of 1.0 μg/side SCH‐23390 reversed cocaine‐CPP, and this dose occupied D1‐like receptors primarily in the rostral pole of the NAc. Intraaccumbens administration of 0.5 μg/side SCH‐23390 reversed cocaine‐induced locomotion. However, this dose occupied a similar number of D1‐like receptors in the NAc as a lower and behaviorally ineffective dose of 0.1 μg/side, but occupied more receptors in the caudate‐putamen relative to both the 0.1 and 1.0 μg/side doses. These findings suggest that stimulation of D1‐like receptors in the NAc is necessary for cocaine‐CPP, but not for cocaine‐induced locomotion. Synapse 30:181–193, 1998. © 1998 Wiley‐Liss, Inc.
IFTE 2018 4th International Forum on Teacher Education INTEGRATED APPROACH TO TEACHER EDUCATION: COMPARATIVE STUDY RESULTS IN RUSSIA, UKRAINE, CHINA

An important condition for a teacher’s successful professional activity is the use of an integrative approach. This approach presupposes: (1) expanding the lesson’s content including information from related fields of knowledge in order to form a multidimensional world picture, (2) creating educational situations that require solving real life problems on the basis of contextual application of knowledge and skills, (3) the variable use of modern pedagogical tools. A comparative study was conducted in Russia, Ukraine and China (in 2015-2017) to determine the readiness of teachers to use an integrative approach in educational practice. It involves readiness assessment of geography teachers for integrative approach introduction in studying sustainable development problems, as well as the arising difficulties analysis and the ways to overcome them. The study included questionnaires and interviews with teachers, expert opinions, databases and analytical notes for the three countries. 537 respondents (school and college teachers, University professors, specialists in the field of retraining), including 192 from Russia, 144 from Ukraine and 237 from China took part in the research. The study results indicate that teachers from the three countries share common difficulties and express similar views on the need to improve their preparation for using an integrative approach. It is noted that a serious disadvantage of modern pedagogical education is the lack of special reference and information resources, elective courses, professional communication environment which help the teacher to develop and implement into educational practice the assignments for studying the realities of modern life using knowledge from different scientific fields. © 2018 Published by Future Academy www.FutureAcademy. org.UK
Apolipoprotein A‐I in bile inhibits cholesterol crystallization and modifies transcellular lipid transfer through cultured human gall‐bladder epithelial cells

Background: Apolipoprotein A‐I (Apo A‐I), conventionally purified by several steps including organic solvent‐delipidation from plasma, inhibits cholesterol crystallization in bile. To observe a significant effect in vitro, however, supraphysiological concentrations above 100 μg/mL are required. For this reason, this protein has not been considered to play a physiological role in vivo. In the present study, we examined the cholesterol crystal growth‐inhibiting effect of biliary Apo A‐I at its physiological concentration, the modification of transcellular transfer of biliary lipids through cultured human gall‐bladder epithelial cells (GBEC) by Apo A‐I at its physiological concentration and the binding and secretion of Apo A‐I by GBEC.
Pulsed electrical stimulation protects neurons in the dorsal root and anterior horn of the spinal cord after peripheral nerve injury

Most studies on peripheral nerve injury have focused on repair at the site of injury, but very few have examined the effects of repair strategies on the more proximal neuronal cell bodies. In this study, an approximately 10-mm-long nerve segment from the ischial tuberosity in the rat was transected and its proximal and distal ends were inverted and sutured. The spinal cord was subjected to pulsed electrical stimulation at T 10 and L 3 , at a current of 6.5 mA and a stimulation frequency of 15 Hz, 15 minutes per session, twice a day for 56 days. After pulsed electrical stimulation, the number of neurons in the dorsal root ganglion and anterior horn was increased in rats with sciatic nerve injury. The number of myelinated nerve fibers was increased in the sciatic nerve. The ultrastructure of neurons in the dorsal root ganglion and spinal cord was noticeably improved. Conduction velocity of the sciatic nerve was also increased. These results show that pulsed electrical stimulation protects sensory neurons in the dorsal root ganglia as well as motor neurons in the anterior horn of the spinal cord after peripheral nerve injury, and that it promotes the regeneration of peripheral nerve fibers.
Right ventricular involvement in acute left ventricular myocardial infarction: prognostic implications of MRI findings.

OBJECTIVE The purpose of this study was to investigate the prevalence and prognostic importance of the cardiac MRI finding of right ventricular involvement in patients with acute ST-segment elevation myocardial infarction (MI). SUBJECTS AND METHODS Fifty patients (41 men, nine women; mean age, 58 +/- 11 years) with first-ST-segment elevation MI underwent 1.5-T cardiac MRI immediately after successful percutaneous coronary intervention. The cardiac MRI protocol included steady-state free precession cine sequences for functional assessment of the left, right, and both ventricles and inversion recovery FLASH delayed enhancement sequences after contrast administration for the quantification of myocardial damage. The prevalence of right ventricular involvement detected with ECG and echocardiography was compared with the prevalence detected with cardiac MRI, which was the reference standard. Patients underwent follow-up for 32 +/- 8 months. RESULTS Right ventricular involvement was diagnosed with cardiac MRI in 27 patients (54%): 14 of 30 patients (47%) with inferior ST-segment elevation MI and 13 of 20 patients (65%) with anterior ST-segment elevation MI. ECG and echocardiographic findings showed only moderate agreement with cardiac MRI findings in the detection of right ventricular involvement in inferior acute MI (kappa = 0.38). Patients with right ventricular involvement in anterior ST-segment elevation MI had larger infarcts (delayed enhancement, 25.9% +/- 14.5% vs 11.4% +/- 10.1%; p = 0.030), lower left ventricular ejection fraction (34.3% +/- 8.2% vs 45.2% +/- 9.5%; p < 0.015), and lower right ventricular ejection fraction (39.8% +/- 6.6% vs 54.9% +/- 8.8%; p < 0.001) than those without right ventricular involvement. In a multivariate logistic regression model, right ventricular involvement was a strong independent predictor (odds ratio, 15.8; 95% CI, 4-63%) of major cardiac adverse events. CONCLUSION Right ventricular involvement in ST-segment elevation MI is detected more frequently with cardiac MRI than with ECG and echocardiography and is an independent prognostic indicator.
Assessing the Effect of Public Capital on Growth: An Extension of the World Bank Long-Term Growth Model

To analyze the effect of an increase in the quantity or quality of public investment on growth, this paper extends the World Bank’s Long-Term Growth Model (LTGM), by separating the total capital stock into public and private portions, with the former adjusted for its quality. The paper presents the LTGM public capital extension and accompanying freely downloadable Excel-based tool. It also constructs a new infrastructure efficiency index, by combining quality indicators for power, roads, and water as a cardinal measure of the quality of public capital in each country. In the model, public investment generates a larger boost to growth if existing stocks of public capital are low, or if public capital is particularly important in the production function. Through the lens of the model and utilizing newly-collated cross-country data, the paper presents three stylized facts and some related policy implications. First, the measured public capital stock is roughly constant as a share of gross domestic product (GDP) across income groups, which implies that the returns to new public investment, and its effect on growth, are roughly constant across development levels. Second, developing countries are relatively short of private capital, which means that private investment provides the largest boost to growth in low-income countries. Third, low-income countries have the lowest quality of public capital and the lowest efficient public capital stock as a share of GDP. Although this does not affect the returns to public investment, it means that improving the efficiency of public investment has a sizable effect on growth in low-income countries. Quantitatively, a permanent 1 ppt GDP increase in public investment boosts growth by around 0.1–0.2 ppts over the following few years (depending on the parameters), with the effect declining over time.
Interferon Gamma in Successful Pregnancies1

Abstract Interferon gamma (IFNG) is a proinflammatory cytokine secreted in the uterus during early pregnancy. It is abundantly produced by uterine natural killer cells in maternal endometrium but also by trophoblasts in some species. In normal pregnancies of mice, IFNG plays critical roles that include initiation of endometrial vasculature remodeling, angiogenesis at implantation sites, and maintenance of the decidual (maternal) component of the placenta. In livestock and in humans, deviations in these processes are thought to contribute to serious gestational complications, such as fetal loss or preeclampsia. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression. Lack of MHC class II antigens on trophoblasts is thought to facilitate survival of the semiallogeneic conceptus in the presence of maternal lymphocytes. This review describes the dynamic roles of IFNG in successful pregnancy and briefly summarizes data on IFNG in gestational pathologies.
Blockade of angiotensin II receptors inhibits the increase in blood pressure induced by insulin.

To elucidate whether hyperinsulinemia increases blood pressure by increasing sympathetic outflow via the activation of the central angiotensin system, insulin was infused into urethane-anesthetized rats intravenously (i.v.) or intracerebroventricularly (i.c.v.) under euglycemic conditions. Infusion (i.v.) of insulin elicited pressor effects in a dose-dependent manner (13, 20, and 40 mU/min). Although depressor responses to i.v. injections of hexamethonium were significantly greater in insulin-infused than in saline-infused rats, i.v. captopril and d(CH2)5Tyr(Me)-arginine vasopressin did not show any differences between the groups. Infusions (i.c.v.) of insulin (8 mU/10 microl) also induced cardiovascular acceleration and augmented the depressor response to i.v. hexamethonium in insulin-infused rats. The i.c. v. pretreatment with the angiotensin II antagonist losartan inhibited the pressor responses to both the i.c. v. and i.v. infusion of insulin. These results suggest that the increase in blood pressure induced by euglycemic hyperinsulinemia is elicited by sympathetic activation and that hyperinsulinemia stimulates the angiotensin system in the brain to increase sympathetic nerve activity.
The renal handling of calcium and phosphorus in environmental cadmium‐exposed subjects with renal dysfunction

Clearance methods were used to clarify the renal handling of calcium (Ca) and phosphorus (P) in a population with renal dysfunction induced by exposure to environmental cadmium (Cd). Seventy‐six Cd‐exposed subjects (32 men and 44 women) and 36 non‐exposed subjects (18 men and 18 womén) took part in this study.
Genome‐scale analysis of library sorting (GALibSo): Isolation of secretion enhancing factors for recombinant protein production in Pichia pastoris

A method combining fluorescence activated cell sorting (FACS) and DNA microarray assisted clone identification was developed and termed Genome‐Scale Analysis of Library Sorting (GALibSo). Genes enhancing the production of secreted heterologous proteins in Pichia pastoris were identified out of a cDNA library by cell surface display and FACS. The trends of gene enrichment during consecutive FACS rounds were monitored by DNA microarrays. In a case study a P. pastoris cDNA library was co‐expressed in a strain secreting the Fab fragment of a monoclonal antibody against human immunodeficiency virus type 1 as a model protein. Three genes were identified, increasing the relative expression level of the surface‐displayed model protein up to 45%. While one of these genes had a positive effect on three out of four tested proteins, the product specific effect of the other two suggested that the effects of the co‐expressed secretion enhancing factors are partly dependent on the protein to be produced. The microarray based monitoring of the enrichment of genes causing enhanced protein secretory capacity led to novel insights into the limitation of protein secretion. Biotechnol. Bioeng. 2010; 105: 543–555. © 2009 Wiley Periodicals, Inc.
Human XTP3-B Forms an Endoplasmic Reticulum Quality Control Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP*

The recognition of terminally misfolded proteins in the endoplasmic reticulum (ER) and the extraction of these proteins to the cytoplasm for proteasomal degradation are determined by a quality control mechanism in the ER. In yeast, Yos9p, an ER lectin containing a mannose 6-phosphate receptor homology (MRH) domain, enhances ER-associated degradation (ERAD) of glycoproteins. We show here that human XTP3-B (hXTP3-B), an ER lectin containing two MRH domains, has two transcriptional variants, and both isoforms retard ERAD of the human α1-antitrypsin variant null Hong Kong (NHK), a terminally misfolded glycoprotein. The hXTP3-B long isoform strongly inhibited ERAD of NHK-QQQ, which lacks all of the N-glycosylation sites of NHK, but the short transcriptional variant of hXTP3-B had almost no effect. Examination of complex formation by immunoprecipitation and by fractionation using sucrose density gradient centrifugation revealed that the hXTP3-B long isoform associates with the HRD1-SEL1L membrane-anchored ubiquitin ligase complex and BiP, forming a 27 S ER quality control scaffold complex. The hXTP3-B short isoform, however, is excluded from scaffold formation. Another MRH domain-containing ER lectin, hOS-9, is incorporated into this large complex, but gp78, another mammalian homolog of the yeast ubiquitin ligase Hrd1p, is not. Based on these results, we propose that this large ER quality control scaffold complex, containing ER lectins, a chaperone, and a ubiquitin ligase, provides a platform for the recognition and sorting of misfolded glycoproteins as well as nonglycosylated proteins prior to retrotranslocation into the cytoplasm for degradation.
Feedback Control Over Lossy SNR-Limited Channels: Linear Encoder–Decoder–Controller Design

In this paper, we consider the problem of encoding and decoding codesign for linear feedback control of a scalar, possibly unstable, stochastic linear system when the sensed signal is to be transmitted over a finite capacity communication channel. In particular, we consider a limited capacity channel which transmits quantized data and is subject to packet losses. We first characterize the optimal strategy when perfect channel feedback is available, i.e., the transmitter has perfect knowledge of the packet loss history. This optimal scheme, innovation forwarding hereafter, is reminiscent of differential pulse-code modulation schemes adapted to deal with state space models, and is strictly better than a scheme which simply transmits the measured data, called measurement forwarding (MF) hereafter. Comparison in terms of control cost as well as of critical regimes, i.e., regimes where the cost is not finite, are provided. We also consider and compare two popular suboptimal schemes from the existing literature, based on 1) state estimate forwarding and 2) measurement forwarding, which ignore quantization effects in the associated estimator and controller design. In particular, it is shown that surprisingly the suboptimal MF strategy is always better then the suboptimal state forwarding strategy for small signal-to-quantization-noise-ratios.
Through silicon via (TSV) noise coupling effects on RF LC-VCO in 3D IC

Through silicon via (TSV) based 3-dimensional integrated circuit (3D IC) has become the key solution to satisfy continuously increasing demands for small form factor, wide bandwidth, high performance, and low power consumption on electronic devices. However, there still remain several challenges to be solved; one of the most significant issues in 3D IC is TSV to active circuit noise coupling. In this paper, we analyzed the noise coupling between TSV and LC-VCO, which is an important component in RF communication system. When TSV is located near LC-VCO, the noise can easily travel through silicon substrate to the body of MOSFETs in LC-VCO. The noise coupling mechanisms of TSV to PMOS and NMOS are analyzed by voltage transfer functions in frequency-domain obtained by 3D electromagnetic solver simulation. The voltage transfer function between TSV and MOS is analyzed under variations of several physical parameters to clarify the tendencies of noise coupling. In addition, the noise coupling effect on PMOS and NMOS in LCVCO are investigated and compared in terms of sensitivity, such as phase noise.
Costs of blood transfusion: a process-flow analysis.

PURPOSE To determine the cost of transfusing 2 units (U) of packed RBCs at a comprehensive cancer center. METHODS We performed a process-flow analysis to identify all costs of transfusing 2 U of allogeneic packed RBCs on an outpatient basis to patients with either (1) solid tumor who did not undergo bone marrow transplantation (BMT), (2) solid tumor who underwent BMT, (3) hematologic malignancy who did not undergo BMT, (4) hematologic malignancy who underwent allogeneic BMT, or (5) hematologic malignancy who underwent autologous BMT. We conducted structured interviews to determine the personnel time used and physical resources necessary at all steps of the transfusion process. RESULTS The mean cost of a 2-U transfusion of allogeneic packed RBCs was $548, $565, $569, $569, and $566 for patients with non-BMT solid tumor, BMT solid tumor, non-BMT hematologic malignancy, allogeneic BMT hematologic malignancy, and autologous BMT hematologic malignancy, respectively. Sensitivity analysis showed that total transfusion costs were sensitive to variations in the amount of clinician compensation and overhead costs, but were relatively insensitive to reasonable variations in the direct costs of blood tests and the blood itself, or the probability or extent of transfusion reaction. CONCLUSION The costs of the transfusion of packed RBCs are greater than previously analyzed, particularly in the cancer care setting.