Miracle-dz/UniFAR-FTUs huggingface dataset:
higher absorption and lower urinary elimination of a new magnesium rice complex compared to two other organic forms of magnesium a pilot study in rats

Magnesium (Mg) supplementation may be required when certain health problems or conditions such as Crohn’s disease or pregnancy cause Mg deficiency for which increasing dietary intake is insufficient. Mg supplements are available as inorganic or organic forms, which are absorbed differently. Although inorganic salts are particularly rich in elemental Mg, organic forms are generally considered to be more bioavailable. This pilot study compared the pharmacokinetics and bioavailability following acute absorption in rats of two organic Mg forms to a new Mg rice complex made from an inorganic, marine Mg oxide and amino acids from a rice protein hydrolysate. The Mg rice complex was well absorbed from the gastrointestinal tract providing a relatively stable serum Mg concentration for up to 12 hours. The 24-h AUC for Mg rice complex was similar to the other two preparations. Mg urinary elimination for Mg rice complex was significantly lower than Mg bisglycinate, although did not significantly differ from Mg glycerophosphate or vehicle. No difference in fecal elimination was observed. The results suggest that Mg rice complex is at least as bioavailable as the two other forms tested. Containing almost twice the amount of elemental Mg than the two other forms, exposure to elemental Mg
Automated Chat Response and Query Grouping using Data Mining Techniques

We are living in a world full of data. The amount of data that is created each day is increasing rapidly. Every day, people encounter a significant amount of information and store or represent it as data, for further analysis and management. One of the essential means of dealing with this data is to organize or group them into a set of clusters or categories. In our paper, we discuss, how an organization's internal chat messaging system can be automated. In the chat messaging system, employees of the team can post queries and also other employees who know the solution to the query can answer it. The queries may not be immediately followed by a solution, as many users post queries and solutions. These queries and solutions are mixed up, as the users randomly post them. To make the chat messaging system more organized and responsive, we propose a novel method to handle a search query and automatically group relevant queries. Then every query and query result is analyzed. Similar/Related queries, as well as query results, are grouped using clustering method. Whenever a user enters a new search query, it is analyzed, and relevant query results are displayed from the query group it belongs.
Biosynthesis of food constituents : Vitamins. 1. Fat-soluble vitamins -a review

This review article gives a survey of the generally accepted biosynthetic pathways that lead to fat-soluble vitamins (vitamin A, vitamin D, vitamin E, vitamin K, the corresponding provitamins, and the closely related ubiquinones and plastoquinones) in animals, plants, and microorganisms. Extensively used are reaction schemes, sequences, and mechanisms with the enzymes involved, with detailed explanations using chemical principles and mechanisms.
Manganese-cerium oxide (MnOx-CeO2) catalysts supported by titanium-bearing blast furnace slag for selective catalytic reduction of nitric oxide with ammonia at low temperature

ABSTRACT A series of manganese-cerium oxide (MnOx-CeO2) catalysts supported by Ti-bearing blast furnace slag were prepared by wet impregnation and used for low-temperature selective catalytic reduction (SCR) of NO with NH3. The slag-based catalyst exhibited high nitrogen oxide removal (deNOx) activity and wide effective temperature range. Under the condition of NO = 500 ppm, NH3 = 500 ppm, O2 = 7–8 vol%, and total flow rate = 1600 mL/min, the Mn-Ce/Slag catalyst exhibited a NO conversion higher than 95% in the range of 180–260 °C. The activity of Mn/Slag catalysts was greatly enhanced with the addition of CeO2. The results indicated that Ti-bearing blast furnace slag had suitable phase composition as good support of SCR catalyst. Implications: Ti-bearing blast furnace slag is a kind of industrial waste in China. Much slag was underused and piling up, which could cause many environmental issues, such as enormous waste of titanium and groundwater and soil contamination by heavy metals in leachates. The utilization of slag as the support of SCR catalyst will not only make use of solid waste but also cut down the NOx emitted from power plant.
Modelos de algoritmos geneticos y redes neuronales en la prediccion del signo de variacion del IPSA

This study analyzes the ability of the recursive dynamics multivaried models constructed through genetic algorithms and the recursive neuronal networks to predict the sign of the IPSA's weekly changes. The data correspond to the period between July 14,1997 and December 9, 2002. The analyzed models were evaluated in 60 series generated by a block-bootstrap process. The results indicate that the network ward would have better forecast ability than the genetic algorithms model and the naive model to predict the sign of the IPSA's changes. The network ward and the genetic algorithms models surpassed, in average, the buy and hold strategy, even when a transaction cost of 0.1 % is considered.
Gene Expression Data Classification Using Locality Preserving Projections

Classification analysis of gene expression data could lead to knowledge of gene functions and diseases mechanisms. However, the data involve nonlinear interactions among genes and environmental factors. Worst yet, while the data are usually of high dimensions, the sample sizes acquirable are generally relatively small, resulting in the well known difficulty ¨C the curse of dimensionality ¨C in the classification task. This work describes how gene expression data can be analyzed using Locality Preserving Projections (LPP) manifold learning method. LPP is a dimensionality reduction strategy for feature selection and visualization. Using LPP, the high dimensional gene expression data are mapped to a low dimensional subspace for data analysis. LPP finds the optimal linear approximations to the eigen functions of the Laplace Beltrami operator on the manifold. Not only does it share many convenient data-representation properties of the nonlinear techniques like Laplacian Eigenmaps or Locally Linear Embedding, it is also linear and more crucially is defined everywhere in the ambient space rather than just on the training data points. Comparative experimental results with PCA, LDA, LLE, etc. on different gene expression datasets show that the LPP-based method has the potential of being more efficient for complex gene expression data classification.
A general overview and bibliometric analysis of seven ACM hypertext and web conferences

Bibliometric analysis of published scientific papers is a widely used practice to conduct quantitative evaluations and assessments of conferences. In this study, we performed an in-depth bibliometric, scientometric and exploratory analysis of ACM SIGWEB sponsored conferences by visually analysing the DBLP database. We conducted a series of experiments and empirical analysis to answer several questions. Our results showed that the articles published in SIGWEB conferences stem from a variety of countries while the degree of cross-country collaboration is relatively low and that most co-authors of publications are by researchers who all reside in the same country. Collectively, SIGWEB conferences have a higher hosting rate and local community participation in places where the USA and Europe make the greatest conference contributions. Our results showed that the participation of female authors in SIGWEB conferences is increasing while in contrast, there is a huge gender imbalance in leadership and official conference positions.
Load Forecasting Mechanism for e-Learning Infrastructures Using Exponential Smoothing

Thanks to the development of cloud technologies, the way how computing is understood has evolved from "computer guided" to "user guided" systems. That is, initially, computers had static software features in which users sharing them had to "fit", but now there is a shift to dynamic systems in which it is the computer which has to fit into the users' needs. This allows more efficient use of computing resources, improving the revenue and enhancing the Quality of Service (QoS) received by users. In order to deploy computing resources when needed without affecting negatively to the QoS perceived by users, accurate predictions on the load of machines should be made. Thanks to this, resources can be ready to use when users need them, and shutdown when they are not needed. This reduces the power consumption and enhances the revenue of the system. This paper presents an algorithm to perform resource provisioning on the machines of the technological infrastructure of our University, so that they can be efficiently managed. This algorithm is based on load forecasts created using Exponential Smoothing.
An 19F Magnetic Resonance–Based In Vivo Assay of Solid Tumor Methotrexate Resistance: Proof of Principle

Purpose: Studies in oncology have implicated multiple molecular mechanisms as contributors to intrinsic and acquired tumor resistance to antifolate therapy. Here we show the utility of an 19F-labeled methotrexate (FMTX) with 19F magnetic resonance to differentiate between sensitive and resistant tumors in vivo and thus predict therapeutic response. Experimental Design: Human sarcoma xenografts in nude mice were used in this study. The sarcoma cell lines chosen for this study (HT-1080, HS-16, and M-805) are well characterized in terms of their methotrexate sensitivity and molecular mechanisms of resistance. The pharmacokinetics of tumor uptake/washout of FMTX were monitored via in vivo 19F magnetic resonance spectroscopy (pulse/acquire with surface coil localization) following an i.v. bolus injection. Response post-therapy, following leucovorin rescue, was monitored via tumor growth. Results: The three tumor models show differences in both the peak concentrations of tumor FMTX and the dynamics of uptake/retention. These differences are most pronounced for time points late in the magnetic resonance observation period (225-279 minutes post-injection). A statistically significant linear correlation between tumor tissue concentrations of FMTX at these late time points and therapeutic response in the days/weeks post-treatment is shown (R = 0.81, F = 9.27, P < 0.001). Interestingly, a 400 mg/kg i.v. bolus injection of FMTX is a more potent cytotoxic agent in vivo against methotrexate-sensitive tumors than is the parent compound (P = 0.011). Conclusions: In principle, the assay method described herein could be implemented in the clinic as a diagnostic tool to make decisions regarding therapeutic protocol for the treatment of osteosarcoma on a case-by-case basis.
Spectrum of gravitational waves in Randall-Sundrum braneworld cosmology

We study the generation and evolution of gravitational waves (tensor perturbations) in the context of Randall-Sundrum braneworld cosmology. We assume that the initial and final stages of the background cosmological model are given by de Sitter and Minkowski phases, respectively, and they are connected smoothly by a radiation-dominated phase. This setup allows us to discuss the quantum-mechanical generation of the perturbations and to see the final amplitude of the well-defined zero mode. Using the Wronskian formulation, we numerically compute the power spectrum of gravitational waves, and find that the effect of initial vacuum fluctuations in the Kaluza-Klein modes is subdominant, contributing not more than 10% of the total power spectrum. Thus it is confirmed that the damping due to the Kaluza-Klein mode generation and the enhancement due to the modification of the background Friedmann equation are the two dominant effects, but they cancel each other, leading to the same spectral tilt as the standard four-dimensional result. Kaluza-Klein gravitons that escape from the brane contribute to the energy density of the dark radiation at late times. We show that a tiny amount of the dark radiation is generated due to this process.
RB1 polymorphism contributes to the efficacy of platinum-taxanes in advanced squamous cell lung cancer.

BACKGROUND RB1 (retinoblastoma 1) was reportedly one of the major determinative factors for sensitivity to taxanes in previous studies. In this study, we investigated the influence of RB1 single nucleotide polymorphisms (SNPs) on the efficacy of platinum-taxane regimens in advanced NSCLC patients. MATERIALS AND METHODS 234 cases of patients with advanced NSCLC who were treated with first-line platinum-taxane agents were enrolled in this study. Genomic DNA was extracted from patients' peripheral blood samples using a QIAamp DNA Maxi Kit, and genotyped by iSelect HD Bead-Chip. RESULTS Regression analyses were conducted through the univariate and multivariate Cox proportional hazards model in the 234 patients. The results showed that of the eight RB1 tagSNPs, only rs4151510 was a positive predictive factor for the advanced NSCLC patients treated with platinum taxanes regimen. The patients with G/G genotype of RB rs4151510 had longer overall survival (OS) than the non-G/G genotype (p=0.018). The histology was also correlated with OS in the whole advanced NSCLC patients. Three tagSNPs of RB1, rs4151510, rs4151465, rs9568036 were significantly associated with OS in the advanced NSCLC patients with squamous cell histology using Kaplan-Meier overall survival analysis stratified by histology. CONCLUSIONS RB1 genomic variants were correlated with the efficacy of platinum-taxanes regimen. RB rs4151510 is an independent factor of the prognosis of NSCLC patients receiving platinum-taxane chemotherapy.
Exploration du niveau de l’atteinte lexico-sémantique dans la démence sémantique

La demence semantique (DS) est une maladie neurodegenerative, caracterisee par une degradation progressive des connaissances semantiques entrainant une perte du sens des mots. Si le manque du mot en situation de denomination fait partie des criteres diagnostiques de DS, le niveau linguistique atteint dans le processus d’acces lexico-semantique n’est pas clairement etabli. Notre etude a pour objectif de determiner si le manque du mot en denomination chez les patients atteints de DS s’accompagne d’une perte de l’acces au genre grammatical, d’une preservation de l’acces au genre alors que la forme du mot ne peut etre activee ou bien s’il est lie a l’atteinte des representations semantiques ou phonologiques/orthographiques, independamment de l’atteinte du genre grammatical. 18 patients atteints de DS ont ete testes a l’aide d’un materiel informatise pour explorer les differentes etapes de l’acces lexical. D’apres nos resultats, cette anomie peut etre liee a l’atteinte des representations semantiques ou a l’atteinte des representations orthographiques, independamment de l’atteinte du genre grammatical ; l’acces prealable au genre ne conditionne donc pas l’acces aux informations lexemiques. Ces observations sont en faveur d’une recuperation du contenu orthographique independante de la recuperation prealable des informations syntaxiques ou semantiques.
SGK1 is modulated by resistin in vascular smooth muscle cells and in the aorta following diet‐induced obesity

Enhanced serum and glucocorticoid‐inducible kinase 1 (SGK1) activity contributes to the pathogenesis of vascular disease. This study evaluated SGK1 modulation in vascular smooth muscle cells by the adipokine resistin and in aortic tissue in a murine model of diet‐induced obesity (DIO).
Towards internal privacy and flexible K-anonymity

The focus on k-anonymity enhancements along the last decade, allows this method to be elected as the point of start for many anonymization researches. In this paper we propose "Contra-Loss", a novel anonymization approach applied at internal level, to enhance local privacy where data is at rest and "Flexible k- anonymity" which aims to apply k-anonymity in most situations by defining a semantic ontology which distinguishes between scanty and abundant quasi-identifiers to achieve adequate k-blocks.
The Abdication of Belief: A Comment on Foxall's Replies to His Critics

As Editor, I tried to remain relatively neutral both to Foxall's original paper and to its responses, but? especially after having read Foxall's "Intentional Behaviorism Revisited"? I find I must invoke an Editor's privilege and jump into the fray (with Foxall's kind assent). What follows is a reply to a reply and, as such, necessarily derives, at least in part, from the comments of Foxall's critics. However, I tried to review Foxall's reply as a "new" paper standing on its own merits and, as such, I wanted to respond to it as if I had not seen the earlier commentaries. This was not possible, of course, but to the extent that I have knowingly or unknowingly borrowed from those critiques without specific reference, I apologize. If I have repeated any of their arguments, I ask those authors to simply consider this a complement to their cogent assessments. I think that a "complete" reply to Foxall's responses to his critics would require a paper much longer than the present one, so I will confine my remarks to a small subset of issues he has raised.
Measurement of nitrate radical concentrations in continental air.

Nighttime profiles of the atmospheric concentrations of the nitrate radical (NO/sub 3/), NO/sub 2/, and O/sub 3/ have been obtained by using a mobile differential ultraviolet/visible absorption spectrometer over path lengths from 3 to 17 km. Measurements were carried out at four semiarid/desert sites in the southern California desert (Death Valley, Edwards Air Force Base, Phelan, and Whitewater), and nitrate radicals were observed at all four locations at typical concentrations of approx. 10-100 parts per trillion. A decrease in the calculated NO/sub 3/ lifetime with increasing relative humidity (RH) was observed with lifetimes up to approx. 60 min for less than or equal to50% RH, but less than or equal to10 min for greater than or equal to50% RH. This suggests the involvement of water in the loss process for NO/sub 3/, either in the gas phase or in the aqueous state at the ground or on aerosol surfaces. These experimental field data support our earlier hypothesis that this loss process of NO/sub 3/ may constitute both a major sink for atmospheric NO/sub x/ and a significant formation route for nitric acid, a key component of acid rain and fog.
A robust and fast video fingerprinting based on 3D-DCT and LSH

A video fingerprinting that extracts fingerprints from videos and finds other similar ones from a reference database, is used for media indexing, content retrieval and copyright management. In this paper, we attempt to extract spatial and temporal information of a video as its fingerprint by Three-dimension Discrete Cosine Transform (3D-DCT) and apply Locality-Sensitive Hashing (LSH) to search the similar ones in the video fingerprint database. It combines the robustness of coefficients of 3D-DCT with the retrieval efficiency of LSH. This system can yield a high precision rate of 98.25% and a recall rate of 88.78%. Experimental results illustrate that our system outperforms existing methods in copy detection based on fingerprint.
Fuzzy Cluster Analysis of Parkinson-Relates mRNA Sequences

The objection of this paper is to analyze the relationship among the interrelated mRNA sequences of the Parkinson Disease (PD). Further this paper will provide a study on genetic factor of the PD's occurrence, so as to provide more information on the PD's prevention, clinical diagnosis and treatment. The respective alignment of the PD's interrelated mRNA sequences with those in The National Center for Biotechnology Information (NCBI) database was studied, and the measurement relationship of these sequences was identified analyzed by the method of fuzzy cluster. The result of fuzzy cluster analysis indicates that the mRNA sequences interrelated within one group are consistently having closer relationship within the group other than in another group.
Detection and identification of Mycobacterium tuberculosis directly from sputum sediments by amplification of rRNA

Seven hundred fifty-eight processed sputum sediments received for the diagnosis of tuberculosis or other mycobacterial infections were tested by utilizing a rRNA target amplification assay and traditional culture techniques. The results from the rRNA target amplification assay (Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test), available in 5 h, were compared with the results from standard culture techniques held for 6 weeks. A total of 119 specimens (16%) were culture positive for Mycobacterium tuberculosis. Overall sensitivity, specificity, positive predictive value, and negative predictive value were 82, 99, 97, and 96%, respectively, for the Gen-Probe assay; 88, 100, 100, and 97%, respectively, for culture; and 53, 99.8, 99.6, and 91%, respectively, for fluorochrome stain. The Gen-Probe assay employs the isothermal enzymatic amplification of M. tuberculosis complex rRNA followed by detection of the amplicon with an acridinium ester-labeled DNA probe. This assay has the potential of reducing the time for diagnosis of tuberculosis to 1 day.
Hyperoxia blunts counterregulation during hypoglycaemia in humans: possible role for the carotid bodies?

Chemoreceptors in the carotid bodies sense arterial oxygen tension and regulate respiration. Isolated carotid body glomus cells also sense glucose, and animal studies have shown the carotid bodies play a role in the counterregulatory response to hypoglycaemia. Thus, we hypothesized that glucose infusion rate would be augmented and neuro‐hormonal counterregulation blunted during hypoglycaemia when the carotid bodies were desensitized by hyperoxia. Seven healthy adults (four male, three female) underwent two 180 min hyperinsulinaemic (2 mU (kg fat‐free mass (FFM))−1 min−1), hypoglycaemic (3.33 mmol l−1) clamps 1 week apart, randomized to either normoxia (arterial () 111 ± 6.3 mmHg) or hyperoxia ( 345 ± 80.6 mmHg) (P < 0.05). Plasma glucose concentrations were similar during normoxia and hyperoxia at baseline (5.52 ± 0.15 vs. 5.55 ± 0.13 μmol ml−1) and during the clamp (3.4 ± 0.05 vs. 3.3 ± 0.05 μmol ml−1). The glucose infusion rate was 44.2 ± 3.5% higher (P < 0.01) during hyperoxia than normoxia at steady state during the clamp (28.2 ± 0.15 vs. 42.7 ± 0.65 μmol (kg FFM)−1 min−1; P < 0.01). Area under the curve values (expressed as percentage normoxia response) for counterregulatory hormones during hypoglycaemia were significantly suppressed by hyperoxia (noradrenaline 50.7 ± 5.2%, adrenaline 62.6 ± 3.3%, cortisol 63.2 ± 2.1%, growth hormone 53.1 ± 2.7%, glucagon 48.6 ± 2.1%, all P < 0.05 vs. normoxia). These data support the idea that the carotid bodies respond to glucose and play a role in the counterregulatory response to hypoglycaemia in humans.
Self-assembly of dendrimers by slippage.

[reaction: see text] A dendrimer with rotaxane-like characteristics has been assembled under thermodynamic control from complementary wedge-shaped precursors by slippage in CH(2)Cl(2). The driving force for the self-assembly process is the molecular recognition that exists as a result of [N(+)-H.O] and [C-H.O] hydrogen bonds between an NH(2)(+) center in one Fréchet-type benzyl ether wedge and a dibenzo[24]crown-8 unit that links the other two such wedges.