Miracle-dz/UniFAR-FTUs huggingface dataset:
DFNet: Semantic Segmentation on Panoramic Images with Dynamic Loss Weights and Residual Fusion Block

For the domain of self-driving and automatic parking, perception is a basic and critical technique, moreover, the detection of lane markings and parking slots is an important part of visual perception. Compared with front sight images, panoramic images(PI) can capture more comprehensive pavement information. However, the imbalance of different classes in PI is even more serious. Additionally, the judgment of boundary information between areas is a hard problem in deep models. Therefore, we propose a new model named DFNet to solve these problems. The proposed model has two main contributions, one is dynamic loss weights, and the other is residual fusion block(RFB). DFNet use dynamic loss weights to overcome the negative effect of imbalance dataset, which are calculated according to the pixel number of each class in a batch. RFB is composed of several convolutional layers, a pooling layer, and a fusion layer to combine the feature maps by pixel multiplication, which can reduce boundary information loss. We evaluate our method on PSV dataset, and the achieved advanced results demonstrate the effectiveness of the proposed model.
Thermal Conductivity of Graphene-Polymer Composites: Mechanisms, Properties, and Applications

With the integration and miniaturization of electronic devices, thermal management has become a crucial issue that strongly affects their performance, reliability, and lifetime. One of the current interests in polymer-based composites is thermal conductive composites that dissipate the thermal energy produced by electronic, optoelectronic, and photonic devices and systems. Ultrahigh thermal conductivity makes graphene the most promising filler for thermal conductive composites. This article reviews the mechanisms of thermal conduction, the recent advances, and the influencing factors on graphene-polymer composites (GPC). In the end, we also discuss the applications of GPC in thermal engineering. This article summarizes the research on graphene-polymer thermal conductive composites in recent years and provides guidance on the preparation of composites with high thermal conductivity.
Overlapping Clustering Models, and One (class) SVM to Bind Them All

People belong to multiple communities, words belong to multiple topics, and books cover multiple genres; overlapping clusters are commonplace. Many existing overlapping clustering methods model each person (or word, or book) as a non-negative weighted combination of "exemplars" who belong solely to one community, with some small noise. Geometrically, each person is a point on a cone whose corners are these exemplars. This basic form encompasses the widely used Mixed Membership Stochastic Blockmodel of networks (Airoldi et al., 2008) and its degree-corrected variants (Jin et al., 2017), as well as topic models such as LDA (Blei et al., 2003). We show that a simple one-class SVM yields provably consistent parameter inference for all such models, and scales to large datasets. Experimental results on several simulated and real datasets show our algorithm (called SVM-cone) is both accurate and scalable.
Twenty-Four-Hour Urine Phosphorus as a Biomarker of Dietary Phosphorus Intake and Absorption in CKD: A Secondary Analysis from a Controlled Diet Balance Study.

BACKGROUND AND OBJECTIVES Twenty-four-hour urine phosphorus is commonly used as a surrogate measure for phosphorus intake and absorption in research studies, but its reliability and accuracy are unproven in health or CKD. This secondary analysis sought to determine the reliability and accuracy of 24-hour urine phosphorus as a biomarker of phosphorus intake and absorption in moderate CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Eight patients with stage 3-4 CKD participated in 2-week balance studies with tightly controlled phosphorus and calcium intakes. Thirteen 24-hour urine collections per patient were analyzed for variability and reliability of 24-hour urine phosphorus and phosphorus-to-creatinine ratio. The accuracy of 24-hour urine phosphorus to predict phosphorus intake was determined using a published equation. The relationships of 24-hour urine phosphorus with phosphorus intake, net absorption, and retention were determined. RESULTS There was wide day-to-day variation in 24-hour urine phosphorus within and among subjects (coefficient of variation of 30% and 37%, respectively). Two 24-hour urine measures were needed to achieve ≥75% reliability. Estimating dietary phosphorus intake from a single 24-hour urine resulted in underestimation up to 98% in some patients and overestimation up to 79% in others. Twenty-four-hour urine phosphorus negatively correlated with whole-body retention but was not related to net absorption. CONCLUSIONS From a sample of eight patients with moderate CKD on a tightly controlled dietary intake, 24-hour urine phosphorus was highly variable and did not relate to dietary phosphorus intake or absorption, rather it inversely related to phosphorus retention.
Clinicopathological and prognostic significance of PD-L1 expression in sarcoma

Abstract Programmed cell death-ligands 1 (PD-L1) is a key immune checkpoint protein and a promising therapeutic target for malignancy tumor immunotherapy. The prognostic value of PD-L1 in patients with bone and soft tissue sarcoma remains controversial. Therefore, this meta-analysis is conducted to evaluate the associations of PD-L1 expression with overall survival (OS), progression-free survival (PFS), and clinicopathological characteristics of sarcoma A comprehensive literature search of PubMed, Web of Science, Embase, and Cochrane Library was conducted for relevant studies. A total of 14 studies published from 2013 to 2017 were included. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted from included studies to assess the association between PD-L1 expression and OS, PFS of patients with sarcoma. Other relevant data were extracted to evaluate the correlations of PD-L1 expression with risk and clinicopathological characteristics of sarcoma. Stata 12.0 software was applied to calculate the strength of association between PD-L1 expression and sarcoma. In total, 14 articles containing 15 independent studies and 1,451 patients were included in this meta-analysis. We found that the high PD-L1 expression was associated with poorer overall survival (HR 1.27, 95% CI: 0.70–1.84 P = .000) and poorer events-free survival (HR 2.05, 95% CI: 1.55–2.70, P = .000) in bone and soft-tissue sarcoma patients. Additionally, we conducted subgroup analysis according to histology type, ethnicity, target of PD-L1 assessment, cutoff, the significant correlations with poor overall survival and events-free survival were also observed. In contrast none of the clinicopathological characteristics (gender, age, tumor site, tumor grade, tumor depth, tumor necrosis rate, metastasis, recurrence, chemotherapy, radiotherapy) was found to be associated with PD-L1 expression in our analysis. The findings from this meta-analysis indicate that PD-L1 expression might be a useful predicative factor of poor prognosis for patients with bone and soft tissue sarcoma.
microRNA‐30d mediated breast cancer invasion, migration, and EMT by targeting KLF11 and activating STAT3 pathway

miR‐30d has been shown to play pivotal roles in cancer development, and has the potential to act as a diagnostic biomarker and therapeutic target in breast cancer. However, the specific function and molecular mechanism of miR‐30d in breast cancer cell growth and metastasis is still unknown. The present study seeks to shed light on the potential contribution of the MiR‐30d‐KLF‐11‐STAT3 pathway in breast cancer. The results revealed that miR‐30d levels were markedly increased in the breast cancer cell lines BT474, MDA‐MB‐231, HCC197, and MDA‐MB‐468 compared with the non‐tumor mammary gland MCF10A cell line. Furthermore, the miR‐30d mimic increased BT474 and MDA‐MB‐231 breast cancer cell survival, inhibited apoptosis and increased Bcl‐2 expression, whilst inhibited Bax protein levels. miR‐30d mimics promote BT474 and MDA‐MB‐231 cell migration, invasion, and mediate the EMT phenotype. However, miR‐30d inhibitors reverse all of the effects of miR‐30d mimics on breast cancer cell biology. Also, we observed that KLF‐11 is a direct target of miR‐30d and KLF‐11 and pSTAT3 expression are determined by miR‐30d. Finally, the results suggest that miR‐30d plays essential roles in breast cancer cells in a manner that is dependent on the levels of KLF‐1 and pSTAT3. In summary, miR‐30d appears to be a novel diagnostic biomarker and treatment target in breast cancer.
Dorsal striatum dopamine oscillations: Setting the pace of food anticipatory activity

Predicting the uncertainties of the ever‐changing environment provides a competitive advantage for animals. The need to anticipate food sources has provided a strong evolutionary drive for synchronizing behavioural and internal processes with daily circadian cycles. When food is restricted to a few hours per day, rodents exhibit increased wakefulness and foraging behaviour preceding the arrival of food. Interestingly, while the master clock located in the suprachiasmatic nucleus entrains daily rhythms to the light cycle, it is not necessary for this food anticipatory activity. This suggests the existence of a food‐entrained oscillator located elsewhere. Based on the role of nigrostriatal dopamine in reward processing, motor function, working memory and internal timekeeping, we propose a working model by which food‐entrained dopamine oscillations in the dorsal striatum can enable animals maintained on a restricted feeding schedule to anticipate food arrival. Finally, we summarize how metabolic signals in the gut are conveyed to the nigrostriatal pathway to suggest possible insight into potential input mechanisms for food anticipatory activity.
Mental health service users’ experiences of an education intervention based on a European Union project: A comparison between nine European countries

Mental health service users (MHSUs) often face difficulties in achieving successful participation in education; however, the tools that could help them succeed are rarely investigated. This study aimed to illuminate the experiences of MHSUs in an education intervention based on a European Union (EU) project. Their experiences are compared across nine EU countries. The data were collected through individual interviews with MHSUs (n = 47) at day activity centres that provide mental health services. An inductive content analysis was used as the method of analysis. Three main categories, which include seven subcategories, are revealed by the analysis. The main categories are as follows: (i) the factors related to MHSUs' educational preparedness, (ii) the dimensions of the learning environment, and (iii) the effects of training intervention. The MHSUs' experiences with the education intervention were similar across all countries. The findings showed that this education intervention is a multidimensional process. It contains social, mental, and physical dimensions linked to a learner and learning environment. These dimensions influence the MHSUs' ability to participate in the education process. At its best, the education intervention supports the personal growth of MHSUs and prepares them for social integration. An education intervention can be a usable tool in the rehabilitation of MHSUs if the multidimensional nature of education is taken into consideration. Therefore, designing and executing education interventions requires the attendance of the MHSUs in cooperation with mental health and education professionals. Our findings suggest a tentative framework that can be used in designing and executing education for MHSUs.
Effects of an Animal-Derived Biostimulant on the Growth and Physiological Parameters of Potted Snapdragon (Antirrhinum majus L.)

To assess the effect a new animal-derived biostimulant on the growth, root morphology, nitrogen content, leaf gas exchange of greenhouse potted snapdragon, three treatments were compared: (a) three doses of biostimulant (D): 0 (D0 or control), 0.1 (D0.1), and 0.2 g L−1 (D0.2); (b) two biostimulant application methods (M): foliar spray and root drenching; (c) two F1 Antirrhinum majus L. hybrids (CV): “Yellow floral showers” and “Red sonnet. ” The treatments were arranged in a randomized complete-block design with four replicates, with a total of 48 experimental units. Plant height (+11%), number of shoots (+20%), total shoot length (+10%), number of leaves (+33%), total leaf area (+29%), and number of flowers (+59%) and total aboveground dry weight (+13%) were significantly increased by the biostimulant application compared to the control, regardless of the dose. The lowest dose resulted in the best effect on the ground plant dry weight (+38%) and, in order to the root system, on total length (+55%), average diameter (+36%), volume (+66%), tips (+49%), crossings (+88%), forks (+68%), projected (+62%), and total surface area (+28%). Compared to the control, plants treated with the biostimulant significantly enhanced leaf (+16%) and root (+8%) nitrogen content, photosynthetic rate (+52%), transpiration rate (+55%), and stomatal conductance (+81%), although there were no changes in dark-adapted chlorophyll fluorescence. Differences in the application method were not evident in the aboveground morphological traits, except in the plant shoot number (root drenching: +10%). The foliar spray compared to root drenching had a significant effect only on flower dry weight (3.8 vs. 3.0 g plant−1). On the other hand, root drenching had a positive effect on ground dry weight (2.7 vs. 2.3 g plant−1), root morphology, leaf-N and root-N content (+3%), transpiration rate (+21%), stomatal conductance (+40%), concentration of CO2 in intracellular spaces (+11%), as well as on the efficiency of Photosystem II (+11%). A higher pot quality was obtained in “Red sonnet” compared to “Yellow floral shower. ” Based on our findings, applying the biostimulant to potted snapdragon at the lowest dose, as part of a fertilizing regime, improves the crop quality in an agro-environmental sustainable way.
Cardioprotection of ischaemic preconditioning is associated with inhibition of translocation of MLKL within the plasma membrane

Necroptosis, a form of cell loss involving the RIP1‐RIP3‐MLKL axis, has been identified in cardiac pathologies while its inhibition is cardioprotective. We investigated whether the improvement of heart function because of ischaemic preconditioning is associated with mitigation of necroptotic signaling, and these effects were compared with a pharmacological antinecroptotic approach targeting RIP1. Langendorff‐perfused rat hearts were subjected to ischaemic preconditioning with or without a RIP1 inhibitor (Nec‐1s). Necroptotic signaling and the assessment of oxidative damage and a putative involvement of CaMKII in this process were analysed in whole tissue and subcellular fractions. Ischaemic preconditioning, Nec‐1s and their combination improved postischaemic heart function recovery and reduced infarct size to a similar degree what was in line with the prevention of MLKL oligomerization and translocation to the membrane. On the other hand, membrane peroxidation and apoptosis were unchanged by either approach. Ischaemic preconditioning failed to ameliorate ischaemia–reperfusion‐induced increase in RIP1 and RIP3 while pSer229‐RIP3 levels were reduced only by Nec‐1s. In spite of the additive phosphorylation of CaMKII and PLN because of ditherapy, the postischaemic contractile force and relaxation was comparably improved in all the intervention groups while antiarrhythmic effects were observed in the ischaemic preconditioning group only. Necroptosis inhibition seems to be involved in cardioprotection of ischaemic preconditioning and is comparable but not intensified by an anti‐RIP1 agent. Changes in oxidative stress nor CaMKII signaling are unlikely to explain the beneficial effects.
Dysregulation of NAD+ Metabolism Induces a Schwann Cell Dedifferentiation Program

The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the importance of SC metabolism in nerve function and in peripheral neuropathies associated with metabolic disorders. Nicotinamide adenine dinucleotide (NAD+) is a crucial molecule in the regulation of cellular metabolism and redox homeostasis. Here, we investigated the roles of NAD+ metabolism in SC functions in vivo by mutating NAMPT, the rate-limiting enzyme of NAD+ biosynthesis, specifically in SCs. NAMPT SC knock-out male and female mice (NAMPT SCKO mice) had delayed SC maturation in development and developed hypomyelinating peripheral neuropathy without axon degeneration or decreased SC survival. JUN, a master regulator of SC dedifferentiation, is elevated in NAMPT SCKO SCs, suggesting that decreased NAD+ levels cause them to arrest at an immature stage. Nicotinic acid administration rescues the NAD+ decline and reverses the SC maturation defect and the development of peripheral neuropathy, indicating the central role of NAD+ in PNS development. Upon nicotinic acid withdrawal in adulthood, NAMPT SCKO mice showed rapid and severe peripheral neuropathy and activation of ERK/MEK/JUN signaling, which in turn promotes SC dedifferentiation. These data demonstrate the importance of NAD+ metabolism in SC maturation and nerve development and maintenance and suggest that altered SC NAD+ metabolism could underlie neuropathies associated with diabetes and aging. SIGNIFICANCE STATEMENT In this study, we showed that Schwann cell differentiation status is critically dependent on NAD+ homeostasis. Aberrant regulation of NAD+ biosynthesis via NAMPT deletion results in a blockade of Schwann cell maturation during development and severe peripheral neuropathy without significant axon loss. The phenotype can be rescued by supplementation with nicotinic acid; however, withdrawal of nicotinic acid leads to Schwann cell dedifferentiation, myelination defects, and death. These results provide new therapeutic possibilities for peripheral neuropathies associated with NAD+ decline during aging or diabetes.
Low incidence of gastrointestinal adverse events over time with a fixed‐ratio combination of insulin glargine and lixisenatide versus lixisenatide alone

This post hoc analysis of gastrointestinal (GI) adverse events (AEs) from the phase 3 LixiLan‐L (NCT02058160) and LixiLan‐O (NCT02058147) trials aimed to determine the frequency and timing of nausea, vomiting, and diarrhoea for iGlarLixi, a titratable, fixed‐ratio combination of insulin glargine 100 units/mL (iGlar) and lixisenatide, versus iGlar alone or iGlar and lixisenatide alone, in patients with type 2 diabetes uncontrolled with oral antidiabetes drugs (OADs) or basal insulin ± OADs. In iGlarLixi‐treated patients, the rate of GI AEs during the initial weeks of treatment was lower versus patients treated with lixisenatide alone (9.6% and 11.7% of iGlarLixi‐treated patients in LixiLan‐L and LixiLan‐O, respectively, vs. 27.5% of lixisenatide‐treated patients in LixiLan‐O). Beyond day 60, these rates were generally low and similar to those of lixisenatide. These lower rates are likely due to the gradual titration of lixisenatide in iGlarLixi. Median durations of intermittent GI AEs in the iGlarLixi arms were 6.0, 2.0 and 2.5 days (LixiLan‐L), and 5.0, 1.0 and 3.5 days (LixiLan‐O), respectively. iGlarLixi‐associated GI AEs were transient, mostly mild or moderate in severity, and occurred mainly during initial titration.
Production of Biofuel Crops in Florida: Switchgrass 1

This series of illustrated fact sheets introduces growers to several potential biofuel crops for Florida, with assessments of potential, description of biology, production, potential yields, production challenges and estimated costs, environmental concerns, and references. Published by the UF Department of Agronomy, January 2008. http://edis.ifas. ufl.edu/TOPIC_SERIES_Production_of_Biofeul_Crops_in_Florida
The Real Exchange Rate, Innovation and Productivity: Heterogeneity, Asymmetries and Hysteresis

We evaluate manufacturing firms' responses to changes in the real exchange rate (RER) using detailed firm-level data for a large set of countries for the period 2001-2010. We uncover the following stylized facts: In emerging Asia, real depreciations are associated with faster growth of firm-level TFP, sales and cashow, higher probabilities to engage in R&D and export. We find no significant effects for firms from industrialized economies and negative effects for firms in other emerging economies, which are less export-intensive and more import-intensive. Motivated by these facts, we build a dynamic model in which real depreciations raise the cost of importing intermediates, but increase demand and the profitability to engage in exports and R&D, thereby relaxing borrowing constraints and enabling more firms to overcome the fixed-cost hurdle for financing R&D. We decompose the effects of RER changes on productivity growth into these channels and explain regional heterogeneity in the effects of RER changes in terms of differences in export intensity, import intensity and financial constraints. We estimate the model and quantitatively evaluate the different mechanisms by providing counterfactual simulations of temporary real exchange rate movements. Effects on physical TFP growth, while different across regions, are non-linear and asymmetric.
The SSJ Framework: Augmenting Social Interactions Using Mobile Signal Processing and Live Feedback

Thanks to recent technological advancements, powerful computers and versatile sensor arrays can now be integrated in small wearable devices. This paper introduces the Android framework SSJ, which makes use of such devices to augment social interaction. To this end, sensor data is first used to analyse the user's behaviour in realtime. Based on the analysis, SSJ then sends live multimodal feedback to the user while they participate in a social interaction. With the help of advanced feedback strategies, SSJ can minimize the disruption of the social interaction while still helping the user improve the quality of their behaviour.
Electronic structure of in-plane functionalized graphane analog interface

As research on 2D materials and functionalization of 2D crystals continues, we focus on the effects full functionalization of -H and -CH3 ligands have on a buckled germanene backbone. The crystal structures of hydrogen-terminated germanene and methylterminated germanene are simulated using crystal modeling software to observe the properties of both materials and determine whether forming a junction in an interface is practical. The work function and density of states of each 2D structure are analyzed to confirm if the ligands can work well in an interface. By simulating the crystal structure of 2D graphane analog interface and performing electronic calculations using Density Functional Theory methods, we can understand more about ligand chemistry on interfaces. Computational modeling of the structures provides novel insights into the properties and electronic structures of the materials. Successful theoretical results yield for potential synthesis of the materials to be used in the future for devices. # The University of Texas at Austin, Austin, TX * To whom correspondence should be addressed: Department of Materials Science and Engineering, The Ohio State University Columbus, OH 43210, USA Email: windl.1@osu.edu