The role of ceramides in cigarette smoke-induced alveolar cell death

S 1. Petrache I, Medler TR, Richter AT, Chukwueke U, Zhen L, Hargreaves CA, Kamocki K, and Tuder RM. The role of oxidative stress in ceramide-induced apoptosis and emphysema-like alveolar enlargement in mice (ATS, 2007). 2. Sohrab S, Fijalkowska I, Smith PA, Gu Y, Kamocki K, Hargreaves C, and Petrache I. Effect of cigarette smoke on the non-canonical protective functions of human alpha 1-antitrypsin (A1AT) in emphysema (FAMRI, 2007). 3. Diab KJ, Gu Y, Adamowicz J, Kamocki K, Berdyshey EV, and Petrache I. S1P augmentation, an alveolar cell pro-survival therapeutic strategy in experimental emphysema (ATS, 2007). 4. Sohrab S, Smith PA, Gu Y,Kamocki K, and Petrache I. Alpha-1-antitrypsin (A1AT) polymerization and cigarette smoke exposure impair the uptake of human A1AT by primary lung endothelial cells. The Fourth Annual Respiratory Disease Young Investigators Forum (Pittsburgh, 2007). 5. Clauss M, Rajashekhar G, Sigua N, Kamocki K, Ahlbrecht K, Oender Yildirim A, Fehrenbach H, Voswinckel R, Petrache I. EMAP II overexpression induces endothelial apoptosis and emphysema in murine lungs ( EB 2008). 6. Kamocki K, Fisher A, Presson R, Sidner R, and Petrache I. Evaluation of cellspecific apoptosis in murine lungs following ceramide-16 PEG intratracheal instillation. (Biochemistry Retreat Program Booklet, Indiana University School of Medicine, 2008). 7. Sohrab S, Petrusca DN, Kamocki K, Adamowicz J, Gu Y, Rush NI, Fisher A, Presson RG, Schweitzer KS and Petrache I. Clathrin-mediated alpha-1antitrypsin internalization by primary lung endothelial cells (ATS, 2009). 8. Petrache I, Schweitzer K, Johnstone B, Traktuev D, Garrison J, Rush N, Adamowicz J, Van Demark M, Fisher A, Cook T, Feng D, Merfeld-Clauss S, Kamocki K, Presson R, Broxmeyer H, March K. Protective effects of adipose stem cells against cigarette-smoke induced lung injury. (7 Annual Meeting of the International Federation of Adipose Therapeutics and Science, Daegu, Korea. October, 2009). 9. Sigua N, Rajashekhar G, Fehrenbach H, Kamocki K, Adamowicz J, Garrison J, Rush NI, Voswinckel R, Twigg HL III, Sethi S, Clauss M, and Petrache I. EMAP II is a novel cigarette smoke-induced biomarker in emphysema (ATS, 2009). 10. Kamocki K, Diab K, Van Demark M, Adamowicz JJ, and Petrache I. Antiapoptotic effects of sphingosine-1 phosphate (S1P) and its analogs on alveolar endothelial and epithelial cells and role in the treatment of emphysema. (SERLC 2009) Oral Presentation. 11. Kamocki K, Diab K, Van Demark M, Adamowicz JJ, and Petrache I. Antiapoptotic effects of sphingosine-1 phosphate (S1P) and its analogs on alveolar endothelial and epithelial cells and role in the treatment of emphysema (Biochemistry Retreat Program Booklet, Indiana University School of Medicine, 2010). 12. Petrache I, Petrusca D, Chen Z, Ndishabandi D, Justice M, Kamocki K, Rush IN, Van Demark M, Adamowicz J, Hubbard W, Choi A. Involvement of ceramides and dihydroceramides in lung apoptosis and authophagy (ATS 2010). 13. Petrache I, Goya J, Rush NI, Van Demark M, Kamocki K, Petrusca DN, Twigg III HL, Garcia JGN, S Ma, Natarajan V, Shen C, Berdyshev E. Ceramide and sphingosine-1-phosphate (S1P) levels in patients with COPD (ATS, 2010). 14. Schweitzer KS, Johnstone B, Cook T, Feng D, Albrecht M, Gao Y, Kamocki K, Cooper S, Broxmeyer H, March K, and Petrache I. Protection of human adipose-derived stem cells against cigarette-smoke induced lung injury NOD/SCID-IL2 null mice: the role of paracrine factors (ATS 2011). 15. Kamocki K, Van Demark M, Fisher A, Rush NI, Presson RG, Adamsky S, Feinstein E, Tuder RM, and Irina Petrache. Novel mechanistic integration of two cigarette smoke-induced stress responses: ceramide and Rtp-801 (Biochemistry Retreat Program Booklet, Indiana University School of Medicine, 2012). 16. Schweitzer KS, Justice M, Albrecht M, Van Demark M, Gu, Gao Y, Kamocki K, Bittman, R, and Petrache I. Therapeutic potential of FTY720-analogs in cigarette-smoke induced lung injury that is dependent upon sphingosine-1 phosphate receptor-1, S1PR1 (ATS, 2012). RESEARCH SUPPORT NIH grants R01 HL077328 (IP) and R21 DA029249 (IP)