Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementing Web-Based Therapy in Routine Mental Health Care: Systematic Review of Health Professionals’ Perspectives

Background Web-based therapies hold great promise to increase accessibility and reduce costs of delivering mental health care; however, uptake in routine settings has been low. Objective Our objective in this review was to summarize what is known about health care professionals’ perceptions of the barriers to and facilitators of the implementation of web-based psychological treatments in routine care of adults in health care settings. Methods We searched 5 major databases (MEDLINE, EMBASE, PsycINFO, CINAHL, and the Cochrane Library) for qualitative, quantitative, or mixed-methods studies exploring health professionals’ views on computer- or internet-based psychological treatment programs. We coded included articles for risk of bias and extracted data using a prepiloted extraction sheet. Results We identified 29 eligible articles: 14 qualitative, 11 quantitative, and 4 mixed methods. We identified the following themes: patient factors, health professional factors, the therapeutic relationship, therapy factors, organizational and system factors, and models of care. Health professionals supported web-based therapies only for patients with relatively straightforward, low-risk diagnoses, strong motivation and engagement, high computer literacy and access, and low need for tailored content. They perceived flexibility with timing and location as advantages of web-based therapy, but preferred blended therapy to facilitate rapport and allow active monitoring and follow-up of patients. They emphasized the need for targeted training and organizational support to manage changed workflows. Health professionals were concerned about the confidentiality and security of client data for web-based programs, suggesting that clear and transparent protocols need to be in place to reassure health professionals before they will be willing to refer. Conclusions Without health professionals’ support, many people will not access web-based therapies. To increase uptake, it is important to ensure that health professionals receive education, familiarization, and training to support them in incorporating web-based therapies into their practice, and to design systems that support health professionals in this new way of working with patients and addressing their concerns. Trial Registration PROSPERO CRD42018100869; https://tinyurl.com/y5vaoqsk
Antidiabetic and Hypolipidaemic Action of Finger Millet (Eleusine coracana)-Enriched Probiotic Fermented Milk: An in vivo Rat Study

SUMMARY Research background Diabetes is a chronic multi-system disease having long term consequences to the health of people suffering from it. This study investigates the role of finger millet (Eleusine coracana)-enriched probiotic fermented milk in alleviating the diabetic complications in streptozotocin-induced diabetic rats. Experimental approach The probiotic strain used in the study was Lactobacillus helveticus MTCC 5463. Study comprised six groups each containing 6 Sprague Dawley rats: two controls (nondiabetic and diabetic), and four diabetic groups fed finger millet-enriched probiotic fermented milk, probiotic fermented milk, finger millet flour or metformin (standard drug). Samples were administered orally for four weeks, and parameters associated with diabetic disorders were studied. Results and conclusions Oral administration of finger millet-enriched milk significantly (p<0.001) decreased (64.26%) the fasting blood glucose level of diabetic rats compared to metformin (56.43%) and diabetic groups receiving the probiotic fermented milk (18.88%) and finger millet flour (47.14%) after four weeks of treatment. The finger millet-enriched milk significantly ameliorated the diabetic symptoms polyphagia and polydipsia and improved body mass. In diabetic control group, body mass was reduced up to 15.60% at the end of experiment, while in the group receiving the probiotic fermented milk, body mass significantly (p<0.0001) increased by about 5-30%. Significant (p<0.0001) reduction in total cholesterol, triglyceride levels in the groups treated with finger millet flour, finger millet-enriched probiotic fermented milk and probiotic fermented milk was observed compared to diabetic control rats. The probiotic fermented milk enriched with finger millet caused significant (p<0.05) decrease in low-density lipoprotein and very-low-density lipoprotein levels (p<0.0001) and insignificant increase in high-density lipoprotein level. A reversal of altered activities of hepatic marker enzymes aspartate transaminase and alanine transaminase was observed in the group receiving the probiotic milk enriched with finger millet. Histological observations of pancreatic tissues and liver showed that the enriched milk prevents more severe changes in the acinar cells and ameliorated the inflammation and alteration in the liver structure to some extent. Therefore, the finger millet-enriched probiotic fermented milk can be a potential functional food in the management of diabetes. Novelty and scientific contribution This is the only paper reporting about the antidiabetic potential of finger millet-enriched milk fermented using probiotic Lactobacillus helveticus MTCC 5463 and Streptococcus thermophilus MTCC 5460. It also shows the synergistic antidiabetic effect of milk and finger millet used in combination, thus offering a novel functional food.
Association of C1q/TNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease

Background Obstructive sleep apnea (OSA) is closely related to the incidence and progression of coronary artery disease (CAD), and the mechanisms linking OSA and CAD are multifactorial. C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling. We aimed to ascertain the clinical relevance of CTRP9 with OSA prevalence in patients with CAD. Methods From August 2016 to March 2019, consecutive eligible patients with CAD (n = 154; angina pectoris, n = 88; acute myocardial infarction [AMI], n = 66) underwent cardiorespiratory polygraphy. OSA was defined as an apnea-hypopnea index (AHI) ≥15 events·h−1. Plasma CTRP9 concentrations were measured by ELISA method. Results Moderate/severe OSA was present in 89 patients (57.8%). CTRP9 levels were significantly decreased in the moderate/severe OSA group than in the no/mild OSA group (4.7 [4.1-5.2] ng/mL vs. 4.9 [4.4-6.0] ng/mL, P = 0.003). The difference between groups was only observed in patients with AMI (3.0 [2.3-4.9] vs. 4.5 [3.2-7.9], P = 0.009). Correlation analysis showed that CTRP9 levels were negatively correlated with AHI (r = −0.238, P = 0.003) and oxygen desaturation index (r = −0.234, P = 0.004) and positively correlated with left ventricular ejection fraction (r = 0.251, P = 0.004) in all subjects. Multivariate analysis showed that male gender (OR 3.099, 95% CI 1.029-9.330, P = 0.044), BMI (OR 1.148, 95% CI 1.040-1.268, P = 0.006), and CTRP9 levels (OR 0.726, 95% CI 0.592-0.890, P = 0.002) were independently associated with the prevalence of moderate/severe OSA. Conclusions Plasma CTRP9 levels were independently related to the prevalence of moderate/severe OSA in patients with CAD, suggesting that CTRP9 might play a role in the pathogenesis of CAD exacerbated by OSA.
Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

The comprehensive understanding and proper use of supramolecular interactions have become critical for the development of functional materials, and so is the biomedical application of nucleic acids (NAs). Relatively rare attention has been paid to hydrophobic interaction compared with hydrogen bonding and electrostatic interaction of NAs. However, hydrophobic interaction shows some unique properties, such as high tunability for application interest, minimal effect on NA functionality, and sensitivity to external stimuli. Therefore, the widespread use of hydrophobic interaction has promoted the evolution of NA‐based biomaterials in higher‐order self‐assembly, drug/gene‐delivery systems, and stimuli‐responsive systems. Herein, the recent progress of NA‐based biomaterials whose fabrications or properties are highly determined by hydrophobic interactions is summarized. 1) The hydrophobic interaction of NA itself comes from the accumulation of base‐stacking forces, by which the NAs with certain base compositions and chain lengths show properties similar to thermal‐responsive polymers. 2) In conjugation with hydrophobic molecules, NA amphiphiles show interesting self‐assembly structures with unique properties in many new biosensing and therapeutic strategies. 3) The working‐mechanisms of some NA‐based complex materials are also dependent on hydrophobic interactions. Moreover, in recent attempts, NA amphiphiles have been applied in organizing macroscopic self‐assembly of DNA origami and controlling the cell–cell interactions.
Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways

Neurodegeneration is a gradual mechanism of neuronal loss arising from numerous cellular and molecular events such as mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis, and the consequence of these processes is neuroplasticity impairment, cognitive diseases, mood-related diseases, and normal cellular activity. Over the last year, major advances have been made in the field of the introduction of herbal compounds with neuroprotective efficacy, one of which is curcumin. Curcumin (diferuloylmethane) is the most abundant turmeric component extracted from the Curcuma longa plant rhizomes. Accumulating evidence indicates that curcumin may induce mitochondrial biogenesis and can function as an antioxidant, anti-inflammatory, and anti-apoptotic agent, which may be used effectively to treat chronic neurodegenerative diseases and any situation in which the neurodegeneration process takes place. Curcumin has been shown to play a critical role in activating two essential signaling pathways phosphatidylinositol-3(PI3)/ protein kinase B(Akt)/ glycogen synthase kinase-3 (GSK3) and PI3/Akt/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) and preventing the incidence of neurodegeneration via these two pathways. Curcumin's protective functions against neural cell degeneration due to mitochondrial dysfunction and consequent events such as oxidative stress, inflammation, and apoptosis in neural cells have been documented and clinical data have increased to suggest that curcumin may be a standard candidate as a neuroprotective agent. Therefore, in this review, we summarized the clinical and experimental studies and interpreted the key contributory mechanisms of neuroprotective properties of curcumin in neurodegenerative diseases and disorders. We also tried to understand the function of PI3/Akt/GSK3 and PI3/Akt/CREB/BDNF signaling pathways in the neuroprotective properties of curcumin and tried to evaluate their association with antioxidant, anti-inflammatory, anti-apoptosis and biogenesis effects of mitochondria.
Efficient GPU Techniques for Processing Temporally Correlated Satellite Image Data

Spatio-temporal processing has many usages in different scientific domains, e.g., geostatistical processing, video processing and signal processing. Spatio-temporal processing typically operates on massive volume multi-dimensional data that make cache-efficient processing challenging. In this paper, we present highlights of our ongoing work on efficient parallel processing of spatio-temporal data on massively parallel many-core platforms, GPUs. Our example application solves a unique problem within Interferometric Synthetic Aperture Radar (InSAR) processing pipeline. The goal is selecting objects that appear stable across a set of satellite images taken over time. We present three GPU approaches that differ in terms of thread mapping, parallel efficiency and memory access patterns. We conduct roofline analysis [4] to understand how the most time consuming GPU kernel can be improved. Through detailed benchmarking using hardware counters, we gain insights into runtime performance of the GPU techniques and discuss their tradeoffs.
Mapping Grasslands Formations and Cultivated Pastures in the Brazilian Cerrado Using Data Mining

Cerrado is the second largest biome in Brazil. Among the land changes in the Cerrado, over 500,000 km2 of the biome have been transformed into cultivated pastures in recent years. Distinguishing the native formations and identifying types of land use and cover in the Cerrado are important tasks for monitoring and protection policy of the biome. Within this context, this work aims at developing a methodology based on remote sensing techniques, to map pasture and native grassland areas in the Brazilian Cerrado. Data related to land use and cover, relief, spectral information from Landsat images and vegetation indices were used to perform the image classification. Decision trees and Support Vector Machines algorithms were used, and the results showed that the analysis and integration of different data sources can aid in the classification process. In order to discriminate areas of cultivated pastures and grassland formations, we obtained accuracies up to 82% in the study area, being able to identify attributes and data required to recognize these areas in the Brazilian Cerrado by remote sensing images. Keywords-Image Processing; Data Mining; Cerrado.
Effects of Jiedu Sangen Decoction on inhibiting invasion and metastasis of colon cancer based on cancer-associated fibroblasts Sirt1-NF-κB pathway

Objective: To observe the effect of Jiedu Sangen Decoction(JSD, consisting of Polygonum cuspidatum, Geum Japonicum Thumnb, Radix Actinidiae Chinensis) and resveratrol on the metastasis capability of colon cancer CT-26 cells, and on the Sirt1-NF-κB signal pathway of Cancer-associated fibroblasts(CAFs). Methods: The BALB/C mice were randomly divided into normal control group, blank group, model group, resveratrol group and Jiedu Sangen Decoction group. The serum was collected after modeling. CT-26 supernatant was collected, was used to make conditioned medium with fresh medium by the ratio of 1∶1. Mouse fibroblast L929 cells at ogarithmic phase were collected, and incubated with conditioned medium for 72 hours to establish CAFs model. The effects of four different serums on the migration ability of colon cancer CT-26 cells were observed using Transwell. The expression quantities of Sirt1 and NF-κB pathway after intervention in normal mice were detected by Western blot. The expression quantities and acting position of Sirt1 and NF-κB pathway in CFAs were detected by immunofluorescence assay. Results: The number of CT-26 cells in the JSD treated group and resveratrol group significantly decreased, when compared with the model group, showing statistical significance(P0.01). Compared with other groups, the expressions of Sirt1 of CAFs increased in the JSD treated group and resveratrol group at 24 h, the expressions of phosphorylation P65 significantly decreased, and the expressions of phosphorylation IKBκ with phosphorylation IKKαβ increased significantly, showing statistical significance(P0.05). Compared with other groups, the Sirt1 fluorescence significantly enhanced in JSD groups and resveratrol group, and interaction with NF-κB in the nucleus. Conclusion: The JSD and resveratrol can inhibit metastasis ability of colon cancer CT-26 cells, enhance the expression of Sirt1 of CAFs, and inhibit the activation of NF-κB pathway of CAFs.
Joint Operation for Mitigating the Power Variability in Balance Circles included Wind and Cogeneration Units using Heat Storage Tank

The fast growing in wind power penetration into power systems can be challenging and expensive due to the intermittency of wind resources. One possible solution to overcome the problems is integrating wind generation with large scale storage. In this paper joint operation of wind power unit and cogeneration power plant with heat storage is studied on the EEX spot market. Based on heat demand, wind power prediction, and spot price forecasting optimal operational schedule is determined one day ahead, where the objective function is the gross profit. In the prediction models classical time series methods are applied while optimal operational schedule is computed by mixed integer linear programming. Keywords-wind power; cogeneration; heat storage; dayahead market; forecasting; optimization
351.2R-94 Foundations for Static Equipment

The committee has developed a discussion document representing the stateof-the-art of static equipment foundation engineering and construction. It presents the various design criteria, and methods and procedures of analysis. design, and construction currently being applied to static equipment foundations by industry practitioners The purpose of the report is to present the various methods. It is not intended to be a recommended practice, but rather a document which encourages discussion and comparison of ideas.
Acute Megacaryoblastic Leukemia in Infants (About a Case)

DOI: 10.21276/sjpm.2018. 3.3. 1 Abstract: Acute megakaryoblastic leukemia, or type 7 (AML 7), is a rare entity defined by a proliferation of blasts of which at least 50% are megakaryoblasts. It represents 0.5 to 2% of acute leukemias (LA) in children and 3 to 10% of acute myeloid leukemias (AML). Patients may have nonspecific symptoms. His diagnosis is based on the presence in the blood or in the marrow of blasts with typical morphology and expressing specific platelet antigens. This observation describes the clinical case of a 19-month-old infant with pancytopenia. The diagnosis of AML7 was made based on explorations of peripheral blood, myelogram, and immunophenotypic analysis. Chemotherapy has been started, with a poor therapeutic response. The patient died in a state of septic shock. We recall through a literature review the clinical, histological and immunophenotypic features of acute megakaryoblastic leukemia.
Automatic Term and Collocation Extraction from English-Croatian corpus

: Term and collocation bases represent valuable additional resources covering specific domain and frequently expressions, which then can be used in further research. The paper presents possible model of building terminology and collocation base, using statistical and linguistic approaches in order to gain experience in building of such resources for the English - Croatian language pair. The aim of the paper is not to evaluate tools, but to give an insight into use of tools and to gain experience in building, training and testing of language resources. In the paper, two types of statistically-based term and collocation bases have been compared, created out of the legislative documentation and then filtered through language dependant linguistic patterns.
Sponsors of the poster awards

08h30 Registration and poster setup + coffee 09h00 Welcome by Prof. Sabine Van Huffel 09h15 Keynote lecture 1 by by Prof. Bart M. ter Haar Romeny: ′Vision for vision′ 09h50 Single slide poster presentations Part I hosted by Prof. Stefaan Vandenberghe 10h15 Keynote lecture 2 by Prof. Hilde Bosmans: ′New developments in x-ray imaging go for improved quality and/or reduced patient dose’ 10h50 Coffee break + poster session 11h20 Keynote lecture 3 by Prof. John Lee: ‘The important role of imaging in guiding photon and photon therapy’ 11h55 Single slide poster presentations Part II hosted by Prof. Stefaan Vandenberghe 12h20 Keynote lecture 4 by Ir. Jennifer Dhont: ‘Latest developments in image-guided radiotherapy for respiratory motion management’ 12h55 Lunch with poster session + industry stands at poster booth 14h20 Company presentations by chair of MedTech Flanders, Karin Scheerlinck 15h20 Keynote lecture 5 by Prof. Steven Laureys: ‘Functional neuroimaging’ 15h55 Poster awards and drink 16h30 End
An Evaluation of Niche Tourism Potentials in Ghaleh-Rudkhan Tourism Target Village Using Activity-Based Segmentation

Purpose - Niche tourism refers to how to use a particular tourism product tailored to the needs of a particular segment of the market. Places with niche tourism products are able to achieve a high position and consolidate their future position in the tourism market. This type of tourism helps distinguish tourism products by creating an image of the destination and helping compete in the increasingly crowded environment of the tourism market. This paper investigates and analyzes the niche tourism attractions in Ghaleh Rudkhan tourist destination village using activity-based segmentation, the attitudes of the host community in dealing with niche tourism development, and the ability to implement tourism projects and socio-economic factors influencing tourism development in the region, which eventually offers solutions to overcome the current and potential challenges in the study area. To collect the data, interview-based methods, focus group interviews, individual observations and analysis of the documents obtained from different sources were used. Design/methodology/approach - A questionnaire was designed and distributed among 383 tourists and 190 rural employees. The data of this study were mainly evaluated using thematic and content analysis methods. Besides, we have also introduced the niche tourism potentials and tourism activities in the region. Finding - The results show that thanks to the economic and social opportunities, local communities support tourism development in Ghaleh Rudkhan; however, the challenges associated with tourism marketing, event management, uncertainty of private sector investors and environmental issues must be addressed through a participatory approach.
NBH WORKING PAPER 2002 / 5 ON THE ESTIMATED SIZE OF THE BALASSA-SAMUELSON EFFECT IN FIVE CENTRAL AND EASTERN EUROPEAN COUNTRIES

In this paper we try to summarise the size of the real appreciation driven by relative productivity differentials i.e. the Balassa-Samuelson (BS) effect in five Central and Eastern European (CEC5) countries, namely the Czech Republic, Hungary, Poland, the Slovak Republic, and Slovenia. Our approach is based on the use of two methods. Firstly, we create a common simple analytical framework for producing some stylised facts, and obtaining an estimate of relative price movements due to different sectoral productivity growth rates. Secondly, we try to summarise the econometric evidence available for the countries, both from individual country and panel estimates. It seems clear from the analyses, based on the alternative approaches, that the BS effect on CPI inflation vis-á-vis Germany does not exceed 2% per annum. The numbers obtained are somewhat different from those that one would obtain from the change in relative prices in the countries considered. This result might be explained by the fact, that in the past, other factors like change in the sectoral wage rates, pricing behaviour and intermediate product prices also contributed to the development of the nontradable and tradable price ratio. As these estimates are based on past data, when productivity differentials were higher than current figures, it is very likely, that as the catching-up proceeds, the magnitude of the BS effect will be even smaller. This would suggest that the real convergence should not endanger the fulfilment of the Maastricht Treaty inflation criterion.
Efficacy, not Efficiency: Adjusting NATO’s Military Integration

1 Dr. Martin Zapfe leads the “Global Security Team” within the Center for Security Studies (CSS) at ETH Zurich. The views expressed in this paper are the responsibility of the author and do not necessarily reflect the opinions of the NATO Defense College or the North Atlantic Treaty Organization. 2 I. Daalder and J. Goldgeier, “Global NATO”, Foreign Affairs, Vol. 85/5, Sept. /Oct. 2006, pp. 105-113. Introduction