Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacologic Inhomogeneity Between the Reactivity of Intramural Coronary Arteries and Arterioles

We hypothesized that because of their size, anatomic location, and hemodynamic function, coronary arteries and arterioles would respond differently to vasoactive substances. Intramural arteries (281.7 ± 23.1 &mgr;m) and arterioles (77.3 ± 6.6 &mgr;m) of the left anterior descending coronary of rats were isolated and cannulated. Spontaneous tone was lower in arteries than in arterioles (81.1 ± 5.7 vs. 53.0 ± 3.9% of passive diameter, p < 0.05 at 60 mm Hg intraluminal pressure). Arterial tone was adjusted by the thromboxane receptor agonist U46619 (5 × 10 −8M) to reach an active tone close to that of arterioles. Bradykinin elicited dilations in both types of vessels. Acetylcholine (10 −6 –10 −5M) dilated arteries (by 42.6 ± 11.5 &mgr;m) but constricted arterioles (by 16.4 ± 9.3 &mgr;m). Sodium nitroprusside and adenosine elicited significantly greater dilations in arterioles than in arteries (by 7.9 and 11.9%, respectively, p < 0.05), whereas dilations to norepinephrine were similar. Inhibition of nitric oxide synthesis caused a significantly smaller constriction in arteries (10.2 ± 3.31%) than in arterioles (31.6 ± 6.9%) and completely blocked bradykinin-and acetylcholine-induced dilations, whereas it did not affect dilations to sodium nitroprusside, adenosine, and norepinephrine. Compared with arteries, arterioles have a greater spontaneous tone and enhanced nitric oxide modulation of basal tone and exhibit greater responsiveness to nitric oxide and adenosine. In addition, nitric oxide synthase is activated differently by pharmacologic stimuli in these segments. The qualitative and quantitative differences among vasoactive responses of coronary arteries and arterioles demonstrated in this study suggest segment-specific roles for endothelial and metabolic factors in regulation of coronary vascular resistance.
Soybean root hairs: A valuable system to investigate plant biology at the cellular level

Plant organs and tissues are composed of many differentiated cell types. Most functional genomic studies sample whole tissues, which dilutes the signals that may arise from individual cells within the population. The result is an averaging of the cellular response. In order to overcome these issues of ‘signal dilution’, methods are needed to allow the full application of modern functional genomics tools to the study of a single differentiated plant cell type. In order to address this need, we developed a method for the isolation of soybean root hair cells, a single epidermal cell type, in sufficient quantities and purity to perform a variety of functional genomic analyses. As a first demonstration of the potential of soybean root hair cells to study plant systems biology, we compared the root hair transcriptome and proteome.
Large-scale implementation and adoption of the Finnish national Kanta services in 2010–2017: a prospective, longitudinal, indicator-based study

In Finland, implementation and adoption of the national Kanta services’ second phase services were carried out step-by-step from May 2010 till December 2017. The Kanta services currently include integrated, interoperable health information from EMR, EHR, PHR and social welfare sources that can benefit patients, care providers and policy makers. In Finland, the Ministry of Social Affairs and Health steers the Kanta services, and was responsible of the first phase implementation activities since July 2007. For the second phase of implementation and adoption of the services, a new national operational coordination function was established by law in January 2011. The adoption and implementation of the Kanta services would not have been possible without joint efforts of stakeholders and provision of adequate (state) funding. A set of indicators for various prospective, longitudinal monthly follow-up were used. The current principal Kanta services include My Kanta Pages (since May 2010), Prescription Centre (May 2010), Pharmaceutical Database (May 2010), Patient Data Repository and Patient Data Management Service (November 2013), Kelain (September 2016), and Client Data Archive for Social Welfare Services (May 2018) and Kanta Personal Health Record (May 2018).
Cerebrovascular complications of cancer.

By Fernando Testai MD PhD (Dr. Testai of the University of Illinois College of Medicine at Chicago received research grants from Dart NeuroScience, the NIH, and the American Heart Association and consulting fees from Medico-legal Consulting.) Vinny Sharma DO (Dr. Sharma of the University of Illinois College of Medicine at Chicago has no relevant financial relationships to disclose.) Originally released September 7, 1994; last updated July 12, 2017; expires July 12, 2020
The mediating role of commitment, trust and satisfaction in the relationship of business to business customer satisfaction and loyalty

Customer loyalty has been prominent for business activities. In situation where failure to satisfy customers would normally cause an early termination of business, customer loyalty can provide higher customer retention rate and continuous business success. In order to create competitive advantages and achieve better results, Business-To-Business (B2B) relationships offer opportunities for organizations. However, increased competition means that businesses must be able to react even faster to win customer loyalty. The main purpose of this study is to evaluate the relationship between customer loyalty and its determinants in industrial environment. Hence, the direct and indirect effect of loyalty antecedents such as service quality, customer value, customer satisfaction, trust and commitment are examined in B2B context. Quantitative approach was used in order to answer the research objectives. Data collection was conducted by distributing 400 questionnaires to national automotive companies in Iran. The data was analyzed using the structural equation modeling (SEM) technique and SmartPLS software. The result of the study indicated that service quality, customer value, customer satisfaction, trust and commitment are important determinants of customer loyalty which are known as the key success factors in automotive industry. Furthermore, customer satisfaction is a mediator between service quality and customer loyalty as well as between customer value and customer loyalty. While, trust and commitment mediated the relationship between customer satisfaction and customer loyalty. The findings imply that the highest effect on customer loyalty is in the relationships between customer satisfaction and trust. The result of this study would enable suppliers to utilize the research model to improve service quality and strengthen the automotive companies’ relationship. Furthermore, the result is useful to managers in business organizations for strategic planning. Finally, recommendations for future investigation and limitations of this study are discussed.
Digitalization and Competitiveness in the Logistics Service Industry

The second decade of the 21st century is best characterized by the term ‘the digital age. ’ Intensive (exponentially growing) technological progress has become part of business for producers, their suppliers, consumers, and also logistics service providers. Consultants specializing in the field of supply chain and logistics (e.g., A.T. Kearney & WHU, 2015; PwC, 2016; Langley et al., 2017) emphasize that modern transport and logistics cannot do without technology. Sensors, robots, automation, cloud computing, data analysis, 3D printing, autonomous vehicles, artificial intelligence, digital twins or blockchain technology on the one hand enable, on the other, trigger changes in supply chains and logistics, and thus also affect the logistics services industry.
Pulmonary embolism revealed on helical CT angiography: comparison with ventilation-perfusion radionuclide lung scanning.

OBJECTIVE We compared helical CT angiography and ventilation-perfusion radionuclide lung scanning as initial tests in the diagnosis of acute pulmonary embolism. SUBJECTS AND METHODS Two hundred sixteen consecutive patients who were clinically suspected of having acute pulmonary embolism underwent helical CT angiography, ventilation-perfusion radionuclide lung scanning, and Doppler sonography of the veins of the legs. On the basis of concordance of the results for ventilation-perfusion radionuclide lung scanning and helical CT angiography and on the degree of clinical suspicion, certain patients underwent pulmonary angiography. Patients without pulmonary embolism at initial evaluation in whom no treatment was instituted were followed up for at least 3 months to determine the potential recurrence of thromboembolic disease. RESULTS Of the 216 patients, 37 (17%) were excluded because of insufficient data to assess the initial event. Final diagnosis for the 179 remaining patients was pulmonary embolism in 68 (37.9%) and no pulmonary embolism in 111 (62.0%), based on pulmonary angiography in 23 patients (12.8%) and concordant imaging findings and outcome in the remaining patients. Statistically significant differences (p < 0.05) were found between sensitivity, specificity, positive predictive value, and negative predictive value for helical CT angiography and ventilation-perfusion radionuclide lung scanning (94.1% versus 80.8%; 93.6% versus 73.8%; 95.5% versus 82%; and 96.2% versus 75.9%, respectively). Interobserver agreement was excellent for helical CT angiography (kappa = 0.72) and moderate for ventilation-perfusion radionuclide lung scanning (kappa = 0.22). CONCLUSION Helical CT angiography could replace ventilation-perfusion radionuclide lung scanning as the initial test for screening patients who are clinically suspected of having pulmonary embolism.
Selective Toxicity and Angiogenic Inhibition by Euglenophycin: A Role in Cancer Therapy?

A recently discovered euglenoid algal toxin, euglenophycin, is known to have anticancer properties. Euglenophycin is closely related to the alkaloid toxin solenopsin A, originally isolated from fire ants, that is an angiogenic inhibitor. Angiogenesis, the formation of new blood vessels, is required for the development of cancers. Three different human leukemia cell cultures (K562, THP-1, and Jurkat), a murine endothelial (SVR), and epithelial (IEC-6) cell lines were treated with euglenophycin at varying concentrations (0 100 μg/ml). After a 48 hour exposure, decreased production of Vascular Endothelial Growth Factor (VEGF) and Angiopoietin 2 (Ang-2) was observed using an Enzyme-Linked Immunosorbent Assay (ELISA). LC50: 48 hour for all cell lines was less than 50 μg/ml. Viability of cell cultures showed a dosage dependent decrease as compared to control using (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay and trypan blue exclusion. Morphological traits of SVR cells determined by phase contrast microscopy and scanning electron microscopy supported toxicity and viability findings. These data strongly suggest that euglenophycin possesses angiogenic inhibition properties, including metabolic retardation of VEGF and Ang-2 production and inhibition of cell proliferation against human leukemia and murine endothelial and epithelial cells. Future animal model research is required to assess euglenophycin’s potential as a new therapeutic anticancer
Low back pain. Smoking linked to back pain.

when there is nerve root irritation. Rest should continue until activity ceases to cause persisting exacerbation of leg pain. The illustration of the "ergonomic position at a desk" contains some basic errors. The lumbar roll is positioned at the thoracolumbar junction and the low back is not supported at all over the iliac crests. The seat of the chair is higher at the front than at the back and would cause discomfort behind the knees. Much better would be a reverse slope or a wedge and the facility to alter the height of the seat to correspond with leg length. The desk itselfis too high and the subject would have to lift his arms to reach over the sharp edge of the table and doing so would cause sustained tension in the shoulder muscles. Also, this easel would be impractical for day to day use, certainly for writing. Much more satisfactory is a 4 inch block placed under the back edge of a board which gives a slope similar to that seen in old desks. Such a system can be dismantled instantly when a flat surface is required. Back pain and indeed most musculoskeletal dysfunction is exceedingly common, but with a few notable exceptions it is poorly taught and poorly catered for within the present organisation of medical services. It is neither a rheumatic problem nor a surgical one, yet its study and proper management rely on the personal interest of individual rheumatologists and orthopaedic surgeons. The recently introduced Diploma in Musculo-Skeletal Medicine is an improvement, but we will never really get to grips with these problems until we bring everything together and establish a properly constituted specialty in musculoskeletal medicine with doctors trained in all aspects of musculoskeletal dysfunction and its appropriate management.
Single Wideband Microstrip Patch Antenna for 5 G Wireless Communication Application

A wide-band microstrip patch antenna for the next generation of wireless communication (5G) is proposed in this paper. The proposed antenna is benefited of a compact size of 30.7×22.4 mm at 6GHz frequency band. The proximity feed technique is used for the matching between radiating patch and the 50Ω microstrip feedline. Based on the simulation results at the chosen frequency, the proposed antenna can cover 5G requirements. The gain of 3.7dB with a directivity of 6.62 dB and a bandwidth of more than 500MHz are obtained from simulation which shows a good agreement between theory and simulation results. Keywords—5G, microstrip patch, wideband
Electromagnetic Fields, Safety and Health

Handling electric equipment may cause currents in the body and the methods and measures to protect people are accepted worldwide. However, the safety and health when exposed to electromagnetic fields which cause also currents in the body, is controversial. The actual guidelines and standards are using safety factors (SF) to protect people. To cope with controversial problems and stochastic effects such as long term effects and the precautionary principle, we propose the introduction of a health factor (HF)
The future of psychiatric case register studies

Psychiatric case registers have been acknowledged as a valuable source of data especially within the field of psychiatric epidemiology (Dupont et al., 1986; Munk-Jorgensen et al., 1993; Hafner and an der Heiden, 1986). It seems natural that psychiatric research based on case registers has mainly been within the field of psychiatric epidemiology, because this field of research depends upon access to large study populations where selection mechanisms can be described explicitly. Applications have included descriptive epidemiological studies of the incidence and prevalence of treated mental disorders (e.g. Der et al., 1990; Gater et al., 1995; Munk-j0rgensen & Mortensen, 1992). Studies of risk factors for mental illness where both the exposure and the outcome data come from the same case register include Wessely & Castle (1991) who studied schizophrenia risk in Afro-Caribbeans. Follow-up studies of the readmission course include Eaton et al. (1991) and Tansella et al. (1995). Case registers have also been used as a sampling frame when selecting groups of patients for further clinical and epidemiological studies (e.g. Vaughn & Leff, 1976; Munk-Jorgensen et al., 1991). The combination of data from psychiatric case registers and other population-based data collections, i.e. record linkage studies (Baldwin et al., 1987) have been applied in different areas of psychiatric epidemiology. Mortality studies include Allebeck & Wistedt (1986) and Mortensen & Juel (1993) as well as many others. Perhaps it is less well known that several classical genetic epidemiological studies in psychiatry as adoption studies, twin studies, and high-risk studies, (Wender et al., 1986; Gottesman & Bertelsen, 1989; Fischer, 1973; Parnas et al., 1993) in part have been based on record linkage.
Giant cell tumors of bone: nonsurgical factors associated with local recurrence.

OBJECTIVE To determine the rate of giant cell tumor (GCT) recurrence and evaluate the factors associated with its recurrence in patients who underwent surgery and submitted to only one adjuvant method. METHODS Forty-one patients (22 female, 19 male; mean age: 34.22 ± 9.70 years) with GCT, who underwent surgical and one adjuvant treatment, were evaluated after a mean follow-up period of 40.17 ± 22.08 months. The average tumor size was 8.51 ± 3.69 cm. The tumors in 18 patients (43.9%) were grade II and in 23 patients (56.1%) grade III, according to the system developed by Campanacci et al. The surgical margin was intralesional resection and curettage in 60.9% of the patients, and marginal or wide resection in 39.1%. RESULTS Nine (22%) of the 41 patients had recurrence. None of the gender (p=0.436), age (p=0.310), site of the tumor (p=0.940), surgical margins (p=0.400) and the type of the filling material (PMMA or autograft) (p=0.680) had an association with recurrence. However, Campanacci grade III (p=0.028) and the size of the tumor (p=0.034) was associated with the recurrence. CONCLUSION Tumor size and tumor grade III according to the Campanacci system appear to be risk factors for local recurrence after the local resection of GCT.
Toward optimal screening strategies for older women

CONTEXT: Optimal ages of breast cancer screening cessation remain uncertain.OBJECTIVE: To evaluate screening policies based on age and quartiles of life expectancy (LE). DESIGN AND POPULATION: We used a stochastic model with proxies of age-dependent biology to evaluate the incremental U.S. societal costs and benefits of biennial screening from age 50 until age 70, 79, or lifetime.MAIN OUTCOME MEASURES: Discounted incremental costs per life years saved (LYS). RESULTS: Lifetime screening is expensive ($151,434 per LYS) if women have treatment and survival comparable to clinical trials (idealized); stopping at age 79 costs $82,063 per LYS. This latter result corresponds to costs associated with an LE of 9.5 years at age 79, a value expected for 75% of 79-year-olds, about 50% of 80-year-olds, and 25% of 85-year-olds. Using actual treatment and survival patterns, screening benefits are greater, and lifetime screening of all women might be considered ($114, 905 per LYS), especially for women in the top 25% of LE for their age ($50,643 per LYS, life expectancy of ∼7 years at age 90). CONCLUSIONS: If all women receive idealized treatment, the benefits of mammography beyond age 79 are too low relative to their costs to justify continued screening. However, if treatment is not ideal, extending screening beyond age 79 could be considered, especially for women in the top 25% of life expectancy for their age.
Pyrolytic Boron Nitride as a Micorstrip Sbustrate Material

The use of pyrolytic boron nitride (PBN) as a substrate material for microstrip integrated structures operating at microwave frequencies is investigated in this paper. Measurements on single line and coupled line structures are reported and compared with previously published theoretical work on this anisotropic material. The physical properties of PBN which affect its use as a practical substrate material are discussed.
Stability of de Sitter spacetime under isotropic perturbations in semiclassical gravity

A spatially flat Robertson-Walker spacetime driven by a cosmological constant is nonconformally coupled to a massless scalar field. The equations of semiclassical gravity are explicitly solved for this case, and a self-consistent de Sitter solution associated with the Bunch-Davies vacuum state is found (the effect of the quantum field is to shift slightly the effective cosmological constant). Furthermore, it is shown that the corrected de Sitter spacetime is stable under spatially isotropic perturbations of the metric and the quantum state. These results are independent of the free renormalization parameters.
Visualisation of massive retrieved newsfeeds in interactive 3D

This report describes work carried out under the Automatic Information Retrieval project at DERA, in building a 4D landscape (a TextScape) which acts as a graphical user interface (GUI) to the DERA-OKAPI search engine. Traditionally search engines present a 2D visual interface (usually a windows-icons-menus-pointer (WIMP) interface) to the user. Key words are entered and the 'hits' are displayed usually in a list form. Unfortunately, the number of documents retrieved is often overwhelming and a significant amount of time is still required to read abstracts and sections of documents in order to determine if they are relevant, even after the search engine has performed relevance ranking. The challenge is how to improve on this. We propose to render the information most immediately required onto the visual attributes of a 3D landscape. Shape, colour and size can then project the information that is sought, and mining the object hierarchy visually returns information more rapidly.
Reliability Design for Large Scale Storage Systems

Data reliability are drawn much concern in large-scale storage systems built from thousands of storage devices, which highly depends on many inter-dependent system parameters, such as the replica placement policies, number of stored objects and so on. Previous work has discussed the impacts of these system parameters on reliability roughly and separately, and seldom provided their optimal values, nor mentioned their optimal combination. In this paper, we present a new object-based-repairing analytic model. Based on analyzing this model in three popular replica placement policies, we figure out the individual optimal values of these parameters at the beginning, and then work out their optimal combination. Compared with the existing models, our model is easier to solve while reaching more integrative and practical conclusions. These conclusions can directly and effectively instruct the designers to build more reliable storage systems.
Improving Business Processes Through Mobile Apps - An Analysis Framework to Identify Value-added App Usage Scenarios

Mobile apps offer new possibilities to improve business processes. However, the introduction of mobile apps is typically carried out from a technology point of view. Hence, process improvement from a business point of view is not guaranteed. There is a methodological lack for a holistic analysis of business processes regarding mobile technology. For this purpose, we present an analysis framework, which comprises a systematic methodology to identify value-added usage scenarios of mobile technology in business processes with a special focus on mobile apps. The framework is based on multi-criteria analysis and portfolio analysis techniques and it is evaluated in a case-oriented investigation in the automotive industry.