Miracle-dz/UniFAR-FTUs huggingface dataset:
Isomorphisms algorithms of genetic

Battle, D.L. and M.D. Vose, Isomorphisms of genetic algorithms (Research Note), Artificial Intelligence 60 (1993) 155-165. We begin with the premise that the role of Holland schemata in directing genetic search should be granted both as a matter of empirical fact and as a natural consequence of the Schema Theorem. From this we conclude that schemata more general than Holland's can also be made to direct genetic search, and that a duality exists between problem representations and which schemata are relevant for their optimization. This duality provides a theoretical framework in which to interpret problem representations.
Aerobic Exercise and Eucalyptus Globulus: Cardio-affective effects on recovery and stress

Introduction: It is necessary to investigate the interrelation between physical exercise and aromatherapy, regarding cardiovascular and affective functions of human. Thus, the aim of this study was to evaluate the effects of aerobic exercise (AE) and eucalyptus essential oil (EO) in cardiovascular and affective responses. Methods: Twelve adults (19-39 years) performed in a randomized order in different days: 1. AE session; 2. Inhalation of EO session; 3. AE + EO session and; 4. Control session. In each session remained at rest over 15min plus 5min to inhaling EO or blank air in Control session. The AE was 15 min run/walk at 80-85% of maximum heart rate. After recovery (30 min) the Cold Pressor Test (CPT) was applied. At rest, recovery and during CPT were measured cardiovascular and affective variables. Results: The variation of systolic blood pressure in the CPT was attenuated by AE +EO (12.3 ± 14.9 mmHg) and EO (12.6 ± 6.7 mmHg) compared to Control (17.3 ± 6.5 mmHg; P < 0.05). AE + EO increased pleasure in recovery (1′ = 1.2 ± 1.9 pts and 30′= 0.6 ± 1.1 pts) and reduced displeasure in stress (-3.4 ± 1.7 pts) when compared to Control in recovery (1′= -0.5 ± 1.4 pts and 30′= -0.7 ± 1.5 pts, respectively; P < 0.05) and stress (-4.6 ± 1.8 pts; P < 0.05). Conclusions: We conclude that aerobic exercise and eucalyptus essential oil attenuated cardiovascular responses and modulated the affect on recovery and stress.
Effects of Thermal Radiation and Rotation on Unsteady Hydromagnetic Free Convection Flow past an Impulsively Moving Vertical Plate with Ramped Temperature in a Porous Medium

The effects of radiation and rotation on unsteady hydromagnetic free convection flow of a viscous incompressible electrically conducting fluid past an impulsively moving infinite vertical plate with ramped temperature in a porous medium are investigated. Exact solution of momentum and energy equations, under Boussinesq approximation, is obtained in closed form by Laplace transform technique. To compare the results obtained in this case with that of isothermal plate, exact solution of the governing equations is also obtained for isothermal plate. The expressions for the primary and secondary skin frictions and Nusselt number are also derived. It is noticed that, for both ramped temperature and isothermal plates, rotation retards fluid flow in the primary flow direction whereas it accelerates fluid flow in the secondary flow direction in the boundary layer region while radiation exerts accelerating influence on the fluid flow in both the primary and secondary flow directions. For ramped temperature plate radiation reduces primary skin friction whereas it tends to increase secondary skin friction. For isothermal plate radiation has tendency to reduce secondary skin friction. Radiation tends to increase fluid temperature for both ramped temperature and isothermal plates. With the increase in time the rate of heat transfer at the plate is reduced for isothermal plate while it is increased for ramped temperature plate.
Toxicity of Bisphenol a on Humans: A Review

Bisphenol A (BPA) is a plastic ingredient produced in large quantities for use primarily in the production of polycarbonate plastics and epoxy resins. The present review focused on different mechanisms of BPA on human health in enzymatic, androgenic, neurological, liver and reproductive systems. The review explained the influence of BPA on different stages of human life likely in foetal stage, children and adults stages. The review also concentrated on how to handle BPA, treatment, preventive measures against BPA exposure
The Association Between A 1 C and Subclinical Cardiovascular Disease The Multi-Ethnic Study of Atherosclerosis

RESEARCH DESIGN AND METHODS — This was a cross-sectional study of 5,121 participants without clinically evident CVD or diabetes (fasting glucose 7.0 mmol/l or use of diabetes medication), aged 47–86 years, enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). Measurements included carotid intimal-medial wall thickness (CIMT) and coronary artery calcification (CAC). Results were adjusted for age, sex, ethnicity, smoking, systolic blood pressure, LDL cholesterol, HDL cholesterol, antihypertensive medication use, lipid-lowering medication use, and BMI.
PAL in paediatrics has been shown to be an independent predictor of a career choice in the specialty

Background: Previous studies have shown peer-assisted learning (PAL) to be an effective method of teaching, with benefits to students and tutors; however, the effect of PAL in paediatrics has not been evaluated in the literature. This study aimed to evaluate a student-led paediatrics revision course for students preparing for examinations in medical specialties. Methods: Students in their specialties year were invited to undergo a 1-day revision course consisting of a lecture and small group teaching, with a supplemental revision booklet. Tutors were recruited from the final-year cohort to facilitate the teaching. Questionnaires containing Likertscale questions (1, strongly disagree; 5, strongly agree) were distributed before and after the course to assess its effectiveness. Results: In all, 62 per cent (87 ⁄ 140) of students who attended the course responded to the study. Students felt significantly more prepared for their exam after the course (mean 3.47 post-course versus 2.16 precourse), and significantly more prepared to manage children in clinical practice (mean 3.49 postcourse versus 2.53 pre-course). Students rated the course as good (4.35 ⁄ 5), with the small group sessions deemed to be the most useful aspect. Tutors agreed that participating had improved their teaching in general (4.0 ⁄ 5), their confidence (4.1 ⁄ 5), their clinical knowledge (3.6 ⁄ 5) and their oral presentation skills (3.8 ⁄ 5). Discussion: The results demonstrate an effective model for students and tutors in building vital skills in paediatrics and exam preparation. This reinforces the holistic positive attributes attainable from peer-assisted learning, and such schemes should be incorporated into undergraduate medical curricula for paediatrics to increase student confidence and potentially increase recruitment to paediatrics. Studies have shown peerassisted learning to be an effective method of teaching Peer learning
From the Southern Association for Vascular Surgery

Background: A variety of patient factors are known to adversely impact outcomes after carotid endarterectomy (CEA) or carotid artery stenting (CAS). However, their specific impact on complications and mortality and how they differ between CEA and CAS is unknown. The purpose of this study is to identify patient and hospital factors that adversely impact outcomes. Methods: Patients who underwent CEA or CAS between 1998 and 2012 (N [ 1,756,445) were identified using the Agency for Healthcare Research and Quality National Inpatient Sample and State Ambulatory Services Databases. A multivariate analysis was completed to evaluate the impact of demographics, patient factors, type of symptoms (transient ischemic attack or cerebrovascular accident), volume of cases (3 per year vs 1-2 interventions), and interventions upon outcomes, perioperative complications (stroke, myocardial infarction, and bleeding), duration of stay, inpatient mortality, and cost. Significant factors were then used as part of a multivariate regression analysis to determine odds ratios. A subgroup analysis using propensity matching evaluating 1:1 risk-matched asymptomatic and symptomatic patients was completed. Patient cohorts were matched on the basis of Charlson scores. Results: Over the study period a total of 1,583,614 asymptomatic CEA, 7317 asymptomatic CAS, 162,362 symptomatic CEA, and 3149 symptomatic CAS patients were included. Symptomatic disease portends a worse outlook after either CEA or CAS. Costs of the procedure increased with complications with stroke adding the most significant cost burden. For risk-matched asymptomatic and symptomatic patients, female gender (P < .001) and performing one or two cases per year (P < .05) were associated with higher cerebrovascular accident risk. In asymptomatic and symptomatic patients, predictors of myocardial infarction included congestive heart failure (P < .001) and peripheral artery disease (P < .05) and predictors of bleeding included peripheral artery disease (P < .05) and chronic obstructive pulmonary disease (P < .01) for symptomatic patients only. For both asymptomatic and symptomatic patients, predictors of mortality included female gender (P < .001) and performing one or two cases per year (P < .01). Female gender was one of the strongest overall predictors of adverse outcome after CAS (odds ratio, 21.39 for death; P < .001). Low volume (<3 cases per year per practitioner) is a predictor of adverse outcome after CAS only. Conclusions: Higher rates of postoperative stroke and inpatient mortality for women undergoing CAS is an unexpected finding, and may indicate that this population is vulnerable to complications after endovascular management. Low volume is a predictor of complications and subsequent mortality primarily for CAS. Patients who undergo CEA continue to have superior outcomes compared with matched cohorts who undergo CAS. (J Vasc Surg 2016;-:1-8.)
Leukaemia fusions and apoptosis 1 Dysregulation of BCL-2 family proteins by leukaemia fusion genes

The genomic lesions that characterise acute lymphoblastic leukaemia in childhood include recurrent translocations that result in the expression of fusion proteins that typically involve genes encoding tyrosine kinases, cytokine receptors and transcription factors. These genetic rearrangements confer phenotypic hallmarks of malignant transformation, including unrestricted proliferation and a relative resistance to apoptosis. In this review, we discuss the molecular mechanisms that link these fusions to the control of cell death. We examine how these fusion genes dysregulate the BCL-2 family of proteins, preventing activation of the apoptotic effectors, BAX and BAK, and promoting cell survival. Recurrent fusion genes in acute lymphoblastic leukaemia Acute lymphoblastic leukaemia (ALL) is the most common form of childhood malignancy. Therapy for ALL is one of the great success stories of modern chemotherapy, and overall cure rates are now >90% in developed countries, depending on molecular subtypes and clinical features (1). The extraordinary improvements in outcomes in ALL have unquestionably been driven by the treatment of patients on international collaborative clinical trials (2), which have made it possible to rapidly recruit sufficient numbers of patients to studies of new treatment regimes. The analysis of treatment responses, based on measurement of minimal residual disease (MRD), has allowed the early identification of treatment failure or relapse, and consequent adjustment of treatment intensity. The next revolution in our understanding of ALL biology is being driven by many studies, involving thousands of patient samples, characterising the genomic landscape of ALL through genome and transcriptome sequencing (3-7). This has led to the recognition of novel molecular subtypes of ALL, defined by the genomic lesions that drive them. Characterisation of leukaemic genomes provides insight into the key molecular pathways involved in ALL subtypes. Many recently identified genomic lesions in ALL are fusion genes, arising from chromosomal translocations (8). These include fusions that activate tyrosine kinases, cytokine receptors and transcription factors. The presence of these fusions has important prognostic and treatment implications. In this minireview, we consider how these genomic lesions promote resistance to apoptosis in ALL.
Improved learning performance based on a flipped classroom concept – a case study

Aim of the research was to improve effectiveness of university education. With the use of new digital tools the learning processes in many different disciplines have been enhanced. However, the traditional class room training can hardly be replaced entirely as the students’ motivation drops with less direct interaction with the instructor. Hence small private online courses are more successful than massive online education. The authors have developed a sophisticated flipped classroom learning approach incorporating various digital tools ranging from different kinds of videos to a class response system combined with class room lectures. The case of the course introduction to management accounting at the University of Applied Sciences Berlin is been presented to demonstrate the usefulness of the flipped classroom concept. An empirical analysis confirms that the students’ acceptance is highest if various methods of teaching are been applied. In particular relying on digital tools only is seen as ineffective and of less value. Eventually, based on the analysis and classroom observations improvement opportunities have been derived in order to further increase the learning performance.
Probabilistic forecasting of the solar irradiance with recursive ARMA and GARCH models DTU Orbit (24/10/2017)

Forecasting of the solar irradiance is a key feature in order to increase the penetration rate of solar energy into the energy grids. Indeed, the anticipation of the fluctuations of the solar renewables allows a better management of the production means of electricity and a better operation of the grid-connected storage systems. If numerous methods for forecasting the mean of the solar irradiance were recently developed, there are only few works dedicated to the evaluation of prediction intervals associated to these point forecasts. Time series of solar irradiance and more specifically of clear sky index show some similarities with that of financial time series. The aim of this paper is to assess the performances of a commonly used combination of two linear models (ARMA and GARCH) in econometrics in order to provide probabilistic forecasts of solar irradiance. In addition, a recursive estimation of the parameters of the models has been set up in order to provide a framework that can be applied easily in an operational context. A comprehensive testing procedure has been used to assess both point forecasts and probabilistic forecasts. Using only the past records of the solar irradiance, the proposed model is able to perform point forecasts as accurately as other methods based on machine learning techniques. Moreover, the recursive ARMA-GARCH model is easier to set-up and it gives additional information about the uncertainty of the forecasts. Even if some strong assumption has been made regarding the statistical distribution of the error, the reliability of the probabilistic forecasts stands in the same order of magnitude as other works done in the field of solar forecasting.
The Spanish Labour Reform and the Courts: Employment Adjustment and the Search for Legal Certainty

Abstract: Legal uncertainty over the fair reasons for redundancy and for substantial modifications of working conditions is an important factor explaining some of the worst imbalances of the Spanish employment relations system. In 2012 the Spanish legislature has passed a comprehensive labour reform, a fundamental part of which attempts to overcome that uncertainty. After identifying the main causes of legal uncertainty, this paper asks if the new role assigned to the labour courts will serve the purpose of the reform and if eventually this will succeed in bringing legal certainty to the realm of employment adjustment measures. Key Words: Labour courts, dismissal, modification of working conditions, labour reform. Legal certainty.
ERRATUM: Safe Induction of Diabetes by High-Dose Streptozotocin in Pigs

To the Editor: Hemosuccus pancreaticus, or bleeding from the ampulla of Vater, is an uncommon cause of gastrointestinal hemorrhage and can occur in the setting of pancreas divisum as well as pancreatic tumors. It has never previously been reported in association with multiple endocrine neoplasia (MEN) syndrome. We describe a case of hemosuccus pancreaticus within pancreas divisum, in a patient with MEN type 1 (MEN-1), which highlights specific diagnostic and management issues that this condition presents. CASE REPORT A 60-year-old woman with a parathyroid adenoma and a previously excised growth hormoneYsecreting pituitary tumor presented with weakness, lethargy, and melena. Laboratory investigations revealed significant anemia: hemoglobin, 80 g/L (reference range, 120Y150 g/L). She was admitted to Bankstown Hospital for blood transfusion and further investigation. Frank bleeding from the minor ampulla was visible at endoscopy. At endoscopic retrograde cholangiopancreatography, cannulation of the major ampulla demonstrated a small ventral duct suggesting pancreas divisum. Attempts to cannulate the minor ampulla were aborted because of vigorous bleeding. An endoscopic ultrasound and computed tomographic scan of the abdomen yielded no further information. Magnetic resonance imaging confirmed pancreas divisum and no other abnormalities (Figs. 1A and B). Due to persistent transfusion-dependent hemorrhage and concern for an occult pancreatic malignancy, surgical exploration and a Whipple pancreaticoduodenectomy were performed. Macroscopic examination of the resected specimen showed pancreas divisum, a dilated pancreatic duct with blood clot adherent to the wall of the dilated minor papilla. There were no other abnormalities. Histological examination of the pancreas showed no evidence of significant pancreatitis (Fig. 1C), neoplasia, or pseudoaneurysms, revealing only low-grade pancreatic intraepithelial neoplasia (PanIN-1A/1B). (Fig. 1D). Following surgical intervention, the patient’s melena and transfusion requirements ceased. She made a complete recovery after surgery.
Performance of Floor Reared White Leghorn Layer on Different Stocking Density and Feed Restriction Regimes

Increase in feed prices in recent years has stimulated renewed interest in the area of fee d restriction and simultaneously the birds have to provide space for feeding, watering and normal movements for their optimum growth and production. Thus, a great emphasis has been laid on feeding system, which employs the use of quantitative or qualitative feed restriction. During growing phase 468 White Leghorn (WLH) birds from random bred control population housed on deep litter housing system were exposed to three feeding regimes viz. T (ad lib.), T (Skip-two-days a week) and T (75% of ad lib.) on three different 1 2 3 stocking densities viz. S (2.5 ft /bird; 20 birds/pen), S (2.0 ft /bird; 25 birds/pen) and S (1.5 ft /bird; 33 1 2 3 2 2 2
Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Andiroba oil (AO) is obtained from an Amazonian plant and is used in traditional medicine. We carried out a comparative study to test the cytotoxicity, genotoxicity, and hematotoxicity of the oil and its nanoemulsion (AN) in vitro (fibroblasts, lineage NIH/3T3) and in vivo (Swiss mice). The AN was characterized by DLS/Zeta, and its stability was investigated for 120 days. The biological activity of AN was assessed in vitro by MTT test and cell morphology analyses and in vivo by micronucleus, comet, and hematotoxicity tests. The AN presented a hydrodynamic diameter (Hd) of and PDI of and good stability at room temperature. The MTT test evidenced the cytotoxicity of AO and of AN only at their highest concentrations, but AN showed lower cytotoxicity than AO. A lower cytotoxicity of AN, when compared to AO, is in fact an interesting data suggesting that during therapeutic application there will be a lower impact in the cell viability of healthy cells. Cytotoxicity, genotoxicity, and hematotoxicity were not observed in vivo. These tests on the biological and toxicological effects of andiroba oil and nanostructured oil are still initial ones but will give a direction to future application in cosmetics and/or the development of new phytotherapics.
Review of recent literature on canine cranial cruciate ligament disease Genetic predisposition and risk factors

Update on the aetiopathogenesis of canine cranial cruciate ligament disease E. J. Comerford1,2; K. Smith1; K. Hayashi3 1Department of Musculoskeletal Biology, Institute of Aging and Chronic Disease, University of Liverpool, Neston, UK; 2School of Veterinary Clinical Science, University of Liverpool, Neston, UK; 3JD Wheat Veterinary Orthopedic Research Laboratory, the Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
EVIDENCE-BASED INTEGRATIVE MEDICINE UPDATES

PERIOPERATIVE GUIDED IMAGERY MAY REDUCE POSTOPERATIVE PAIN AND IMPROVE PSYCHOLOGICAL WELL-BEING Level 2 (mid-level) evidence Reference: Complement Ther Med. 2013; 21(6):697–711. Mind–body therapies are intended to harness the mind's innate capacity to favorably influence health. Examples include mindfulness meditation, hypnosis, guided imagery, yoga, tai chi, biofeedback, and some forms of cognitive
Fabrication of polystyrene/detonation nanographite composite microspheres with the core/shell structure via pickering emulsion polymerization

Polystyrene microspheres coated with detonation nanographite particles have been prepared by Pickering emulsion polymerization using azobisisobutylonitrile (AIBN) as initiator in aqueous solutions. In the present techniques, the pristine detonation nanographite particleswere employed as stabilizer of Pickering emulsion and then were armored on the as-prepared polystyrene cores by the thermal polymerization. The composite microspheres of polystyrene/detonation nano-graphite (PS/DNG) were characterized by field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), thermogravimetric and differential thermal analysis (TGA-DTA), and Fourier transformation infrared spectrum (FT-IR). FE-SEM indicates that the resulting samples retain spherical shape, with the uniform size ranging from 100 to 150 µm and good dispersity. FT-IR presents the possible formation mechanisms of PS/DNG composites. The functional groups on the surface of polystyrene and modified detonation nano-graphite particles have played an important role for the formation of PS/DNG composites. Moreover, the wettability of different nanographite was also tested.
Soslowsky Tendon Full-Thickness Tears on Infraspinatus Tendon Strain Interaction Between the Supraspinatus and Infraspinatus Tendons : Effect of Anterior Supraspinatus

http://ajs.sagepub. com/content/37/9/1831 The online version of this article can be found at: DOI: 10.1177/0363546509334222 2009 37: 1831 originally published online May 29, 2009 Am J Sports Med Nelly Andarawis-Puri, Eric T. Ricchetti and Louis J. Soslowsky Tendon Full-Thickness Tears on Infraspinatus Tendon Strain Interaction Between the Supraspinatus and Infraspinatus Tendons: Effect of Anterior Supraspinatus