Miracle-dz/UniFAR-FTUs huggingface dataset:
VHL , MEN 2 , NF 1 , SDHA , SDHB , SDHC , SDHD , SDHAF 2 , TMEM

Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are neural crest cell tumors associated with catecholamine production and assessed by a metanephrine/methoxytyramine measurement. Genetic research over the past 10 years has led to a better understanding of the pathogenesis of these tumors, currently associated with 19 susceptibility genes (both somatic and germ-line mutations). Although most of these genes can be divided into two clusters (Cluster 1 and 2), recent data suggests that all mutations converge on the hypoxia-inducible factor signaling pathway. Most of the susceptibility genes are well characterized and associated with specific clinical presentations, including biochemical phenotype, tumor location and behavior, as well as neoplasms or similar characteristics. Correct and early detection of hereditary PHEO/PGL is paramount, since early diagnosis leads to improved and focused treatment, along with better outcomes. However, missed or delayed diagnosis of hereditary PHEO/PGL forestalls proper treatment and results in multiple, recurrent, or metastatic
Exploration of the Relationship Between Moral Judgment Development and Crystallized Intelligence

Introduction . Statement of the Problem . Purpose of the Study . Research Question . Method . Participants . Measures . Moral Judgment . Verbal Ability/Crystallized Intelligence Human Rights Attitudes Procedure . D e s i g n . Results. Discussion . References . Appendices A. Demographics Survey . B. Defining Issues Test (DIT) C. Attitudes Toward Human Rights Inventory (ATHRI)
RANSAC needs not initialization and more robust , so we adopt the RANSAC algorithm as

A new feature based image mosaic method is presented in this paper. Our main contribution is an improved RANSAC algorithm based on the modified median flow filter to find the inliers and the homography between the images. This algorithm overcomes the limit of local feature detection and thus improves the stability of homography calculation. Except for the RANSAC algorithm, PCA-SIFT is used to detect features because it is more compact, more robust and faster than the standard SIFT. The priority search is also used to match the feature points in a faster way than BBF search. Experiments show that our method is robust for image mosaic.
Metastasis Mesenchymal Transition and − Targeting ROR 1 Inhibits Epithelial

Metastasis is responsible for 90% of cancer-related deaths. Strategies are needed that can inhibit the capacity of cancer cells to migrate across the anatomic barriers and colonize distant organs. Here, we show an association between metastasis and expression of a type I receptor tyrosine kinase–like orphan receptor, ROR1, which is expressed during embryogenesis and by various cancers, but not by normal postpartum tissues. We found that expression of ROR1 associates with the epithelial–mesenchymal transition (EMT), which occurs during embryogenesis and cancer metastasis. Breast adenocarcinomas expressing high levels of ROR1 were more likely to have gene expression signatures associated with EMT and had higher rates of relapse and metastasis than breast adenocarcinomas expressing low levels of ROR1. Suppressing expression of ROR1 in metastasis-prone breast cancer cell lines,MDA-MB-231, HS-578T, or BT549, attenuated expression of proteins associatedwith EMT (e.g., vimentin, SNAIL-1/2, and ZEB1), enhanced expression of E-cadherin, epithelial cytokeratins (e.g., CK-19), and tight junction proteins (e.g., ZO-1), and impaired theirmigration/invasion capacity in vitro and themetastatic potential ofMDA-MB-231 cells in immunodeficientmice. Conversely, transfection ofMCF-7 cells to express ROR1 reduced expression of E-cadherin andCK-19, but enhanced the expression of SNAIL-1/2 and vimentin. Treatment of MDA-MB-231 with a monoclonal antibody specific for ROR1 induced downmodulation of vimentin and inhibited cancer cellmigration and invasion in vitro and tumormetastasis in vivo. Collectively, this study indicates that ROR1 may regulate EMT and metastasis and that antibodies targeting ROR1 can inhibit cancer progression and metastasis. Cancer Res; 73(12); 3649–60. 2013 AACR.
The Effect of Entrepreneurial Marketing on Outcome Goals in SMEs

This study examines how entrepreneurial marketing dimensions (proactiveness, opportunity focused, leveraging, innovativeness, risk taking, value creation, and customer intensity) are related to qualitative and quantitative outcome measures for the SME and the entrepreneur (including company success, customer success, financial success, satisfaction with return goals, satisfaction with growth goals, excellence, and the entrepreneurʼs standard of living). Using factor analysis, three success outcome variables (financial, customer, and strong company success) emerged together. A separate factor analysis identified satisfactory growth and return goals. Stepwise regression revealed entrepreneurial marketing impacts outcome variables, particularly value creation. Implications for entrepreneurs and areas for research are included.
Author ’ s Accepted Manuscript Imaging of the High Risk Carotid Plaque : Magnetic Resonance Imaging ( MRI )

The emergence of the concept of high-risk atherosclerotic plaque has led to considerable interest in non-invasive imaging techniques to identify high-risk features prior to clinical sequelae. For plaques in the carotid arteries, magnetic resonance imaging (MRI) has undergone considerable histological validation to link imaging features to indicators of plaque instability including plaque burden, intraplaque hemorrhage, fibrous cap disruption, lipid rich necrotic core, and calcification. Recently introduced imaging technologies, especially those focused on three-dimensional imaging sequences, are now poised for integration into the clinical workup of patients with suspected carotid atherosclerosis. The purpose of this article is to review the carotid plaque MRI techniques that are most ready for integration into the clinic.
Vindicating Social Capital: its Conceptual Convenience

The article sustains that the main conceptual contribution of social capital (SC) emerges from the important role that plays in collective action dilemma. If we understand this role, we get two conceptual advantages: on the one hand, it´s possible to introduce additional arguments to overcome the apparent inconvenience of holding cooperative interactions as prisoner´s dilemma shows. On the other hand, facing up SC´s criticisms, is feasible to argue that cooperation is a neutral dimension and can lean toward a “dark side” (i.e. organized crime) or to collective benefits with no negatives externalities. At the same time, there are some institutional contexts and some SC´s features that promote an incentive structure oriented to take the second route. To sustain this the article: (a) briefly analyses the main perspectives on SC in terms of cooperation; (b) establishes the problem of cooperation as a collective action dilemma; and then, (c) discusses the conditions that grant either a positive or a negative effect of SC.
THE POST-BARIATRIC PATIENT Nutritional Changes Following Massive Weight

Background: The “epidemic” of obesity has recently been accompanied by a new “epidemic” of massive weight loss. The demand for post-bariatric contouring is rising and, as such, it is extremely important for plastic surgeons to be well versed in the treatment of these patients. Unfortunately, the problem is not solely surgical. Objectives: The aim of this article is to understand the nutritional and psychological complications that can occur in patients following massive weight loss, to understand the anatomic deformities in massive weight loss as a means to correct those deformities surgically, and to understand the complications from post-bariatric contouring procedures in an effort to avoid them. Methods: This article discusses the nutritional and psychological considerations in the massive weight loss patient, anatomical considerations in this patient group, and the surgical techniques designed to address these anatomic concerns. Important pertinent studies are reviewed and discussed. Results: Anatomical changes are encountered in each region of the body: there are surgical options available to correct them, although potential complications are associated with these surgical procedures. These surgical options are reviewed as well as the risk and benefits associated with them. Conclusions: There are many problems that need to be addressed in the massive weight loss patient prior to embarking on surgical treatment. Additionally, surgery on massive weight loss patients has unique considerations that distinguish these operations from those performed on the non-bariatric population. Accepted for publication December 8, 2014; online publish-ahead-of-print April 22, 2015.
Theory of Adaptive Adjustment

Conventional adaptive expectation as a mechanism of stabilizing an unstable economic process is reexamined through a generalization to an adaptive adjustment framework. The generic structures of equilibria that can be stabilized through an adaptive adjustment mechanism are identified. The generalization can be applied to a broad class of discrete economic processes where the variables interested can be adjusted or controlled directly by economic agents such as in cobweb dynamics, Cournot games, Oligopoly markets, tatonnement price adjustment, tariff games, population control through immigration etc.
Expression of a SK2-type dehydrin gene from Populus euphratica in a Populus tremula × Populus alba hybrid increased drought tolerance

A dehydrin gene, isolated from cDNA library established from the root of Populus euphratica , was determined from sequence analysis to be an SK2-type dehydrin ( Pedhn ). To investigate the function of Pedhn , it was expressed via the CaMV 35S promoter in transgenic Populus tremula × Populus alba . The Pedhn transgenic lines demonstrated higher water retention capacities in excised leaves of transgenic lines than that of wild type, and the rate of water loss in the leaves of transgenic lines were slower than that of wild type controls under drought stress. Higher water retention capacity and reduced water loss suggest that the transgenic lines would exhibit enhanced drought tolerance. Consistently, the seedlings of transgenic lines did have significantly enhanced drought tolerance when compared with that of the wild type controls under drought challenge, which indicated that expression of Pedhn could be used to genetically modify poplar to improve drought tolerance. Key words: Dehydrin, transgenic poplar, pedhn, drought tolerance.
A risk management model for healthcare facility services purchasers

The non-core business objectives for NHS Trusts in the UK are to provide modern and comfortable healing environments for patients, staff and visitors (customers), as well as flexible workplaces that front the provision of responsive and seamless clinical services. The need to achieve these objectives economically has meant that healthcare FM operations are now being considered strategically as value-adding business services. This is in comparison to the past where they were considered as “backroom” services with no corporate or strategic value. In managing non core/clinical operations, key performance risks associated with such complex business transactions in the NHS are highly unavoidable from a business process re-engineering perceptive. Furthermore, today in a 24 hour shopping environment healthcare is provided in the UK, the management of FM operations involve highly qualitative and critical management risk factors. Quite often healthcare facilities managers as decision-makers tend to use a multivariate of factors and sub-attributes/constructs to evaluate the total influence of such factors on the FM service delivery process. Hence precise prediction of how each risk factor collectively with its respective constructs will affect the NHS trust's FM service delivery (best practice) strategies by means of an absolute evaluation value is too “risky”. This paper provides preliminary results and an analysis of the major critical risk factors faced by healthcare FM purchasers in a bid to improve their business performance.
Tumor and Stem Cell Biology PPAR a ActivationCanHelpPrevent andTreatNon – SmallCell Lung Cancer

Non–small cell lung cancer (NSCLC) not amenable to surgical resection has a high mortality rate, due to the ineffectiveness and toxicity of chemotherapy. Thus, there remains an urgent need of efficacious drugs that can combat this disease. In this study, we show that targeting the formation of proangiogenic epoxyeicosatrienoic acids (EET) by the cytochrome P450 arachidonic acid epoxygenases (Cyp2c) represents a new and safe mechanism to treat NSCLC growth and progression. In the transgenic murine K-Ras model and human orthotopic models of NSCLC, we found that Cyp2c44 could be downregulated by activating the transcription factor PPARa with the ligands bezafibrate and Wyeth-14,643. Notably, both treatments reduced primary and metastatic NSCLC growth, tumor angiogenesis, endothelial Cyp2c44 expression, and circulating EET levels. These beneficial effects were independent of the time of administration, whether before or after the onset of primary NSCLC, and they persisted after drug withdrawal, suggesting the benefits were durable. Our findings suggest that strategies to downregulate Cyp2c expression and/or its enzymatic activity may provide a safer and effective strategy to treat NSCLC. Moreover, as bezafibrate is a well-tolerated clinically approved drug used for managing lipidemia, our findings provide an immediate cue for clinical studies to evaluate the utility of PPARa ligands as safe agents for the treatment of lung cancer in humans. Cancer Res; 74(2); 621–31. 2013 AACR.
What is a Workers’ Referendum for? Evidence from Italy

In July 2007, the Prodi government and representatives of the three main Italian trade union confederations signed a landmark agreement on welfare and economic development. In October, in order to ratify or reject the agreement, the Italian labor movement organized a referendum, i.e. the Workers’ Referendum of 2007, inviting workers, pensioners and the unemployed to assess the agreement. Based on a comprehensive sampling (1,574 interviewees), these research notes provide an analysis of the Workers’ Referendum with regard to both key societal voting features and attitudes toward unions.
Natural and synthetic peptide-based biomaterials for bone tissue engineering

Abstract Introduction Since the dawn of human civilisation, biomaterials used for bone tissue engineering have evolved dramatically. More than 5,000 years ago, the ancient Egyptians used carved shells to replace teeth, but today, a bewildering variety of biomaterials, including autografts, allografts, xenografts, demineralised matrices, ceramics, polymers and composites, are used to replace/repair/regenerate bone tissues. Within this potpourri, natural and synthetic peptide-based biomaterials are promising candidates that could facilitate bone regeneration. This owes much to two properties of these peptidic biomaterials: (i) their facile fabrication into two/three-dimensional scaffolds that mimic the extracellular matrix of the bone and (ii) their controlled functionalisation with chemical cues that direct bone tissue growth. This review examines how these two properties could lead to biomaterials that facilitate bone tissue growth. Conclusion In this review, we have shown how biomaterials used for bone regeneration and tissue engineering have progressed from the exploitation of biomaterials extracted from natural sources to the preparation of synthetic peptide-based scaffolds. While a great deal has been learned about fabricating a functional bone biomaterial, much also remains to be uncovered.
Vichien kitpreechavanich Conversion of Sugarcane Shoots to Reducing Sugars

Sugarcane Shoots is an abundantly available residual resources consisting of lignocelluloses which take it into the benefit. The present study was focused on utilizing of sugarcane shoot for reducing sugar production as a substrate in ethanol production. Physical and chemical pretreatments of sugarcane shoot were investigated. Results showed that the size of sugarcane shoot influenced the cellulose content. The maximum cellulose yield (60 %) can be obtained from alkaline pretreated sugarcane shoot with 1.0 M NaOH at 30 C for 90 min. The cellulose yield reached up to 93.9% (w/w). Enzymatically hydrolyzed of cellulosic residual in 0.04 citrate buffer (pH 5) with celluclast 1.5L (0.7 FPU/ml) resulted in the highest amount of reducing sugar at a rate of 32.1 g/l after 4 h incubation at 50°C, and 100 C for 5 min . Cellulose conversion was 55.5%. Keywords—Conversion, Sugarcane Shoots, Reducing Sugars.
Higher monotonicity properties of certain Sturm-Liouville functions. V

Synopsis The principal concern here is with conditions on f or on special solutions of the equation which ensure that the higher differences of the zeros and related quantities of solutions of (1) are regular in sign. In particular, by choosing f(x)= 2v−2x1/v−2, it is shown that if ⅓ ≦|v|<½, then where cvk denotes the kth positive zero of a Bessel function of order v and Δµk = Δk+1 − µk. Lorch and Szego [15] conjectured that (2) should hold for the larger range | v | < ½ but the methods used here do not apply to the range | v <| ⅓.
Effects Of Thalidomide And rhGM-CSF on Carbohydrate Metabolism In HL-60 Acute Promyelocytic Leukemia Cell Line

The purpose of this study is to investigate the in vitro effect of thalidomide and rhGM-CSF on energy metabolism rate in HL-60 cell lines. HL-60 cells were incubated with radiolabelled glucose for 4 hours. Following incubation, radiolabelled CO2 was isolated and collected in specially designed scintillation vials. The other end-products of carbohydrate catabolism collected via anion-exchange chromatography were analyzed using liquid scintillation. Protein and glycogen levels for each group were also determined. The study results indicated that the use of drugs for 2-days had no significant effect when compared with aerobic and anaerobic controls. However, groups treated with the drugs for 5 days showed significant differences. It was obvious that rhGM-CSF caused HL-60 leukemia cells to use aerobic glycolytic pathway for production of energy. When thalidomide and rhGM-CSF combination therapy results were compared with untreated control cells, it was observed that glycogen consumption was decreased by 50.37%, and CO2 production was increased by 94.03%. When compared with those of anaerobic controls, glycogen consumption and CO2 production rates were found to be decreased by 54.01% and increased by 96.59%, respectively. As a consequence, we found that those cell lines treated with combined use of Thalidomide and rhGM-CSF caused HL-60 leukemia cells to predominantly prefer aerobic glycolytic pathways for energy production.
Recent Progress on Nanostructures for Drug Delivery Applications

With the rapid development of nanotechnology, the convergence of nanostructures and drug delivery has become a research hotspot in recent years. Due to their unique and superior properties, various nanostructures, especially those fabricated from self-assembly, are able to significantly increase the solubility of poorly soluble drugs, reduce cytotoxicity toward normal tissues, and improve therapeutic efficacy. Nanostructures have been successfully applied in the delivery of diverse drugs, such as small molecules, peptides, proteins, and nucleic acids. In this paper, the driving forces for the self-assembly of nanostructures are introduced. The strategies of drug delivery by nanostructures are briefly discussed. Furthermore, the emphasis is put on a variety of nanostructures fabricated from various building materials, mainly liposomes, polymers, ceramics, metal, peptides, nucleic acids, and even drugs themselves.
SHAPING OF ION PULSES FROM AN ELECTRON BEAM ION SOURCE FOR PARTICLE INJECTION INTO ACCELERATORS

Electron Beam Ion Sources (EBISs) provide highly charged ions (HCIs) for many applications, amongst others for particle injection into accelerators. Although EBISs are limited in ion output they feature a lot of advantages which qualify them for accelerator injection. The ion pulses extracted from the ion sources can be directly injected into an accelerator sequence which however requires ion pulses with distinct shape and length. The ions are produced by trapping in a high density electron beam for a certain time with electrostatic potentials providing for their axial trapping. Due to the ion energy distribution within the trapping region ion extraction can be controlled by controlling the trapping potential. A specific time dependent control mode of the trapping potential thus allow for the production of ion pulses with designated shape and length. Source parameters such as working gas pressure, electron beam current and energy influence the energy distribution of the ions which in turn influence the pulse shaping.
Copper, phosphorus and calcium in bovine blood and seminal plasma in relation to semen quality

The mean Cu concentration in blood plasma of bulls of 12 Holstein and 13 Czech Spotted breeds was 22.27 urnol.l"; P, 1.78 mmol.l"; Ca, 3.04 mmol.l"; P:Ca ratio, 0.64. The mean Cu concentration in seminal plasma of bulls was 38.17 u.mol. 1'; P, 12.07 mmol.l"; and Ca, 3.52 mmol.l" and the P:Ca ratio was 3.31. The relationship between Cu, P and Ca concentration in blood and seminal plasma is expressed by calculated phenotypic coefficients of correlation. Highly significant positive coefficients of correlation (PO.01) were found between the Cu, P and P:Ca ratio in blood and seminal plasma (Cu rp=0.36, P r=0.32 and P:Ca ratio r=0.28). In contrast, no positive relationship between the Ca concentration in blood plasma and seminal plasma was found; the calculated coefficient of correlation was negative (r =-0.16). This was probably caused by the higher Ca concentration in blood plasma of bulls. Statistically significant (P<0.05) positive coefficients of correlation were found between the Cu concentration in blood plasma and the total number of sperm in ejaculate (f 0.33), between the Cu concentration in blood plasma and the total number of sperm with progressive motility (r=0.35), and between the Ca concentration and monthly value of sperm motility (rp=0.26). Positive coefficients of correlation were found between the Cu concentration in seminal plasma and the mean monthly volume of ejaculate (r=0.36, PO.01), between the Cu concentration in seminal plasma and sperm motility (rp=0.33, P<0.05), and Cu concentration in seminal plasma and total number of sperm with progressive motility in ejaculate (rp=0.28, P<0.05). The P concentration in seminal plasma of bulls was positively correlated with the sperm concentration in ejaculate collected on test days (rp=0.36, PO.01). The correlation between the P:Ca ratio in seminal plasma and the sperm concentration in ejaculate collected on test days was positive (rp=0.39, PO.01) and so was the correlation between the P:Ca ratio and the mean monthly sperm concentration (r =0.28, PO.05). The calculated coefficient of correlation between the Ca concentration in seminal plasma and the mean monthly sperm motility was negative (r =-0.38, PO.01). * Supported by Ministry of Education and Youth, Grant No MSM 432100001 426 M I N E R A L S I N BLOOD A N D S E M I N A L PLASMA I N BULLS It can be concluded that there is a positive relationship between the Cu and P concentrations and P:Ca ratio in seminal plasma of bulls and the quality and quantity parameters of ejaculate of active stud bulls. A higher concentration of Ca in seminal plasma negatively affected mainly sperm motility in this study.