Miracle-dz/UniFAR-FTUs huggingface dataset:
IDENTIFICATION OF NOVEL DRUGGABLE TARGETS IN TWO MEMBERS OF MONONEGAVIRALES

Measles virus (MeV) is considered one of the most contagious human viruses and has recently been declared endemic again in several countries despite a highly efficacious vaccine. The viral RNA dependent RNA polymerase (RdRP) is a heterologous complex comprised of the large protein (L), which provides all catalytic domains for RNA synthesis, and the phosphoprotein (P), which provides chaperone support for L and mediates the interaction between L and the ribonucleoprotein complex (RNP). Though essential for polymerase function, the interface between P and L remains poorly characterized, as well as the role of P in RdRP advancement along the RNP. Through biochemical interface mapping, functional assays, and domain swapping of P, we have identified a bipartite L binding domain on P. One domain consists of a conserved helical motif upstream of the oligomerization domain (OD), and the second is a face of the P X-domain (PXD). Using stoichiometrically-controlled transcomplementation studies and applied mathematical modeling, we also determined the PXD:L interaction to be mutually exclusive to the PXD:N interaction. These findings suggest a model that centers PXD as a master regulator of RdRP advancement. Rabies virus (RABV) causes a severe and 100% fatal neurological disease that is vaccine preventable and treatable prior to the onset of clinical symptoms. The postexposure prophylaxis (PEP) for RABV treatment is prohibitively expensive, especially in developing countries where the majority of cases occur and does not confer crossprotection against the newly emerging phylogroup II lyssaviruses. To address the unmet clinical need for cross-protective anti-RABV therapeutics, we developed and implemented an innovative high-throughput screening approach utilizing a novel single cycle RABV reporter strain maintained in BSL-2 laboratory conditions. From our extensive screening library, we have identified the first direct-acting multi-strain RABV entry inhibitor, GRP-60367. Resistance profiling of GRP-60367 revealed escape mutations that accelerate the fusion kinetic of the RABV glycoprotein (G). We have solved two of the feasibility issues with current RABV antiviral drug discovery: i) BSL-2+ RABV containment restraints and ii) reliable drug efficacy determination, thus paving the way for future drug discovery campaigns to alleviate the deficit and cost of current therapeutic options against lyssaviruses. INDEX WORDS: measles virus, rabies virus, RNA-dependent RNA polymerase, protein-protein interactions, antiviral, drug discovery, high-throughput screening IDENTIFICATION OF NOVEL DRUGGABLE TARGETS IN TWO MEMBERS OF MONONEGAVIRALES
PLHER (radio plaquetas/hematocrito): una herramienta para discriminar pacientes adultos atendidos en la sala de emergencias con o sin sangrado agudo.

Objetivo. La aproximación al diagnóstico de sangrado agudo (SA) manifestado con síntomas inespecíficos, utilizando el hematocrito como laboratorio de apoyo es un reto en la Sala de Emergencias (SE). Se compararon las capacidades operativas del hematocrito y radio plaqueta/hematocrito (PLHER) para discriminar pacientes con SA. Métodos. Con un diseño de precisión diagnóstica, se compararon pacientes con y sin SA atendidos en la SE de la Clínica del Occidente S.A. durante el 2017. El espectro de enfermedad (EDx) incluyó controles negativos[grupo_0], población general con o sin trauma ortopédico cerrado[grupos_1-2], pacientes con trauma ortopédico cerrado [grupo_3], con SA ginecológico [grupo_4], SA gastrointestinal [grupo_5] y controles positivos [grupos_6-7]. Se compararon las capacidades operativas del PLHER y hematocrito para discriminar pacientes con SA. Resultados. 655 pacientes fueron seleccionados, principalmente hombres. No hubo diferencias entre las medianas de hematocrito del grupo_0 con los grupos 1-2; comparado con el grupo 0, la mediana del PLHER fue mayor en todos los grupos del EDx. (p:<0.05). Con los puntos de corte ≥6.037 y ≥6.348 el AUC del PLHER para discriminar pacientes con posible SA [grupos 1-3] o cualquier grupo del EDx [grupos 1-7] fue 0.709 y 0.766, respectivamente. Los AUC del hematocrito para discriminar pacientes con posible SA o cualquier grupo del EDx fueron 0.682 y 0.755, respectivamente. Discusión. El PLHER presentó mejores capacidades operativas que el hematocrito para discriminar pacientes con SA. Podría ser útil para identificar pacientes con SA atendidos con signos y síntomas inespecíficos en la SE.
Distributionally Robust CVaR Constraints for Power Flow Optimization

Recent research on optimal power flow (OPF) in networks with renewable power involves optimizing both first and second stage variables that adjust the decision once the uncertainty is revealed. In general, only partial information on the underlying probability distribution of renewable power production is available. This paper considers a distributionally robust framework for solving the OPF problem. The formulation stipulates a probability mass function of wind power production, whose probabilities and scenario locations vary in a box of ambiguity with bounds that can be tuned based on historical data. Distributionally robust optimization (DRO) is used to derive new conditional value-at-risk (CVaR) constraints that limit the frequency and severity of branch flow limit violations whenever the renewable power generation deviates from its forecast. Numerical results are reported on networks with up to 2736 nodes and contrasted with classical robust optimization (RO) and stochastic optimization (SO) solutions. The results show an advantage to adopting the proposed DRO for load flow control. In particular, the solution benefits from the observed correlation amongst the uncertain parameters to mitigate branch flow limit violations, and yet maintain an acceptable worst-case expected operational cost as compared to RO and SO solutions.
Mathura (MBI) - A Novel Imputation Measure for Imputation of Missing Values in Medical Datasets

Propose an imputation measure for filling missing data values so as to make the incomplete medical datasets as complete datasets. Apply this imputation measure on imputed datasets to achieve improved classifier accuracies. The basic intention of the present study is to present an imputation measure to find the proximity between medical records and an approach for imputation of missing values in medical datasets to improve the accuracy of existing classifiers. The performance of proposed approach is compared to existing approaches with respect to classifier accuracy and also by performing non-parametric test called Wilcoxon test. Experiments are conducted by considering three benchmark datasets CLEVALAND, PIMA, ECOLI and by applying proposed imputation technique with KNN, J48 and SMO classifiers and classifier accuracies are determined. The results obtained are then compared to thirteen existing benchmark imputation techniques available in KEEL repository. Experiment results proved the importance of the proposed imputation technique.
Pathophysiology of age-dependent hypertension in male Sprague-Dawley rats

Background: Hypertension is a major health concern with a myriad of possible causes. Sodium is a major component of blood pressure regulation implicated in the maintenance of fluid volume. The blood pressure response to changes in salt intake varies considerably among individuals; salt-sensitive individuals exhibit increases in blood pressure parallel to elevated sodium intake, whereas saltresistant individuals maintain constant blood pressure regardless of variations in sodium intake. Salt-Sensitive Hypertension (SSH) develops due to an impairment of normal mechanisms that react to an elevated sodium load. Aging is another major risk factor for the development of hypertension. The effects of aging have a profound impact on the cardiovascular, renal, and nervous systems, which work together to regulate blood pressure. The development of SSH and impact of aging on blood pressure have been well-established, but the neurophysiological mechanisms implicated in SSH and aging, have only been recently explored. Objective: To provide mechanistic insight regarding the integrated roles of the renal and nervous systems in age-dependent hypertension in male SpragueDawley (SD) rats. Methods: Male SD rats of various ages were randomly assigned to various experimental protocols. 3-month-old male SD rats were randomly assigned to
The effects of the CHANGE! intervention on children's physical activity and health

Low childhood physical activity levels, and high paediatric overweight and obesity levels, carry a considerable burden to health including cardiometabolic disease, low fitness, and reduced psychosocial well-being. Numerous school- based physical activity interventions have been conducted with varied success. This thesis therefore aimed to develop and investigate the effectiveness of the Children's Health, Activity and Nutrition: Get Educated! (CHANGE! ) project, which was a school-based curriculum intervention to promote healthy lifestyles using an educational focus on physical activity and healthy eating. The purpose of the formative study (Study 1) was to elicit subjective views of children, their parents, and teachers about physical activity to inform the design of the CHANGE! intervention programme. Analyses revealed that families have a powerful and important role in promoting health-enhancing behaviours. Involvement of parents and the whole family is a strategy that could be significant to ~ncrease children's physical activity levels. There is large variation in the cut-points used to define moderate physical activity (MPA), vigorous physical activity (VPA) and sedentary time, which impacts on accurate estimation of physical activity levels. The purpose of Study 2 was to test a field-based protocol using intermittent activities representative of children's physical activity behaviours, to generate behaviourally valid, population-specific cut-points for sedentary behaviour, MPA and VPA. These cut-points were subsequently applied to CHANGE! to investigate changes in physical activity (Study 3). The CHANGE! intervention resulted in positive changes to body size and VPA outcomes after follow-up. The effects were strongest among those sociodemographic groups at greatest risk of poor health status. Further work is required to test the sustained effectiveness of this approach in the medium and long-term. Further, the development of an inexpensive and replicable field- based protocol to generate behaviourally valid and population-specific accelerometer cut-points may improve classification of physical activity levels in children, which could enhance subsequent intervention and observational studies.
The importance of stockmanship to maintain high standards of handling and transport of livestock and poultry.

Abstract Both practical wisdom and scientific research show the importance of good stockmanship. Cattle, pigs, sheep and poultry that fear people have lower productivity. Animals that willingly approach people are more productive. The best stock people have a positive attitude, and like animals. Equipment and technology will never replace the need for skilled stockmanship and handling to reduce stress. Managers often make the mistake of attempting to use new technology as a substitute for stockmanship and handler training. To motivate continuous improvement and to prevent practices from slipping back into old bad habits, the use of numerical outcome measures is strongly recommended. The following parameters should be measured - falling, stumbling, vocalization during handling, becoming miscaught in a squeeze chute, and electric prod (goad) usage. There are six steps for continuous improvement of stockmanship: 1. Teach people to have a positive attitude, to remain calm and not to yell. 2. Teach stock people to be observant. 3. Teach basic livestock behaviour and movement patterns. 4. Use numerical scoring to prevent deterioration of handling practices. 5. Maintain the highest level of herding and handling, which will require a high skill level. 6. Do not understaff or overwork stock people.
English poems categorization using text mining and rough set theory

In recent years, Text Mining wasan important topic because of the growth of digital text data from many sources such as government document, Email, Social Media, Website, etc. The English poemsare one of the text data to categorization English Poems will use Text categorization, Text categorization is a method in which classify documents into one or more categories that were predefined the category based on the text content in a document . In this paper we will solve the problem of how to categorize the English poem into one of the English Poems categorizations by using text mining technique and Machine learning algorithm, Our data set consist of seven categorizations for poems the data set is divided into two-part training (learning)and testing data. In the proposed model we apply the text preprocessing for the documents file to reduce the number of feature and reduce dimensionality the preprocessing process converts the text poem to features and remove the irrelevant feature by using text mining process (tokenize,remove stop word and stemming), to reduce the feature vector of the remaining feature we usetwo methods for feature selection and use Rough set theory as machine learning algorithm to perform the categorization, and we get 88% success classification of the proposed model.
Rethinking the Scientific Integrity of Young College Teachers: A Study of the Retracted Publications from Journals*

—Scientific integrity emphasizes teachers’ innovation, self-restraint and self-development. However, pushed by the “publish or perish” norm and challenging evaluation regulations, teachers and researchers need more publications. Due to the high pressure, some teachers would risk their reputation and integrity and be reduced to committing academic fraud or misconduct in their researches or published articles. The direct possible consequence would be retractions of some published articles by some journals. In this paper, focusing on the research question “How to Set the Bottom Line of Scientific Integrity for Young College Teachers? ”, an analysis of the retracted publications was conducted to evaluate the status quo of academic fraud. The principal methods applied in our research are literature analysis. According to the findings, reasons for retractions by journals are mainly misconduct accounting for more than 70% (including fraud, fabrication, plagiarism, faked peer review, duplicate publication, no permission from institutions or researchers), as well as error (honest/ administrative error), etc. Rethinking the retractions would help to offer suggestions in improving the academic level of young teachers and setting up a bottom line of scientific research, which can promote the progress of science and technology, create a good academic environment, and then contribute to the construction of a healthy and scientific education system.
The Review of attributes of pomegranate in view of Iranian traditional medicine and Modern medicine

Background and Purpose: In traditional medicine of Iran has explanted the detail of benefit and damage of plants. The pomegranate is one of the plants have noticed in traditional medicine in Iran. It has prescript for prevention, treatment and controlling of diseases. This essay has research the attributes of some part of the pomegranate in parts of the human body . From this view we compare traditional medicine with modern medicine. Methods and Materials: In this essay we have research with some original books In Iranian traditional medicine, such as: Canon of Medicine, makhzan ol advieh, Tohfatolmomenin, ashamel, kholasatolhekmat about attribute of pomegranate. And even we derivate some science essay in source information like: Google scholar PubMed. It has discussed and searches the property of this valuable plant. Conclusion: According of some experiences in last hundred years and new knowledge, pomegranate can use for treatment of very diseases alone or as complementary treatment. Results: In traditional medicine . pomegranate is a plant that has different parts like: fruits, leaf, and stem. Root which are very valuable in medicine. This property is in all kinds of the pomegranate: Such as sour pomegranate, sweet and sour-sweet ones. That we have called: gabs According to Iranian medicine, every material that has gabs cause invigoration. If this material enter in every organ of body invigorate it and prevent to enter poison in its pomegranate causes invigoration of stomach, prevention of liver bleeding, healing of wound ,prevention of cause some headaches associated with brain ,improvement of some diseases in ears and throat and nose, remove some post nasal discharges , anti-allergic , anti-heart diseases, anticancer, anti-inflammation effects ,control of diabetes and cure some skin problems.
Prevention of Post-Splenectomy Sepsis: creation of a vaccination and patient education guideline

The post-splenectomy sepsis is rare, but is associated to a high mortality, justifying the existence of various recommendations for its prevention, including the vaccination and strategies for patient education. Antibiotic prophylaxis remains no consensual. Moreover there are different guidelines with different recommendations, in addition to a serious problem of non-compliance or ignorance by most of physicians. Hence, there are patients without any preventive measure. In Portugal, there are no protocols or clinical guidelines about this entity, except a reference in the national vacination plan. So, we propose one vaccination and education protocol for these
Phase I trial of a dual TOR kinase and DNA-PK inhibitor (CC-115) in advanced solid and hematologic cancers.

2505Background: CC-115 is a potent inhibitor of DNA-PK and TOR kinase (DNA-PKi/TORKi) with broad pre-clinical anti-tumor activity. Methods: Subjects with relapsed/refractory advanced solid and hematologic cancers enrolled in a first-in-human Phase 1a/b study of CC-115 given orally once or twice daily until disease progression in dose escalation and expansion cohorts. Results: 44 subjects evaluated across 10 dose escalation cohorts (0.5 – 40 mg) established 10 mg twice-daily (BID) as the recommended dose for cohort expansion in 62 additional subjects with glioblastoma multiforme (GBM: 14), head and neck squamous carcinoma (HNSCC: 18), chronic lymphocytic leukemia (CLL: 8), and ETS-overexpressing tumors (castration-resistant prostate cancer [CRPC: 12] and Ewing’s sarcoma [ES: 10]). The most common (> 20%) expansion phase related adverse events were fatigue (37%), nausea (31%), decreased appetite (29%), and hyperglycemia (24%). Linear, dose proportional exposure was observed with a terminal half life of 4 to.
Precise determination of the optical properties of turbid media using an optimized integrating sphere and advanced Monte Carlo simulations. Part 2: experiments.

Based on theoretical investigations of the light propagation within an integrating sphere, we developed an accurate method to determine the optical properties of scattering media using an integrating sphere-based setup. The method takes into account the exact sphere geometry as well as the different angular distributions of the reflected and transmitted light from the sample and the calibration standard. We tested our novelties successfully in theory with Monte Carlo simulations and in practice using a 3D printed and professionally coated integrating sphere. As a result, we were able to determine precisely the effective scattering coefficient, μs', and the absorption coefficient, μa, between 400 nm and 1500 nm in a range of μa=1e-3mm-1 to 10mm-1 and μs'=0.2mm-1 to 100mm-1. Usually, the accuracy was around 1% for μs' and around 3% for μa for turbid phantom media with an optical thickness τ=μs'd>1 and a transmittance signal >0.1%.
Simultaneous Surgical Ablation of Atrial Fibrillation with Cardiac Surgery: A Review

1Şişli Kolan International Hospital, Clinic of Cardiovascular Surgery, İstanbul, Turkey 2Sancaktepe Martyr Professor İlhan Varank Training and Research Hospital, Clinic of Cardiovascular Surgery, İstanbul, Turkey 3İstanbul University İstanbul Faculty of Medicine, Department of Cardiovascular Surgery, İstanbul, Turkey Ergun Demirsoy1, Murat Uğur2, İbrahim Demir3 EJCM 2019;7(4):161-165 DOI: 10.32596/ejcm.galenos. 2019.03. 015 Review Article
Clinical outcome and evaluation of patients with distal end radius fractures operated with volar plate and pronator quadratus repair versus no repair

Introduction: Dista l radi us fracture is the commonest fracture of upper extremity that we found during emergency or during orthopaedic practice, Now a days volar plating is more commonly perfomed surgery for the same. During this type of surgical exposure pronator quadrtus muscle is vital structure to come across and for this separation of muscle from radius must be done but after plate placement there is controversy regarding the repair of muscle is there. Repair of pronator quadratus muscle after plate fixation will protect volar flexo r tendon by covering the implant and also helpfull in pronation. Conversely if tight closure done its lead to ischemic contracture and its lead to limited wrist supination and pronation. Materials and Methods: This study was conducted on 30 patients having distal radius fractures operated with volar plating done by trained orthopaedic surgeon at our hospital in B. J. medical college, Civil hospital Ahmedabad between january 2017 and January 2019. The mean follow- up time was approximately 24 months. A standard volar approach was used and PQ muscle was separted from radius side and repaired after fracture fixation and were followed up post operatively. Result: Repair of pronator quadratus after volar radius plate fixation is depends on surgeon choice, here we have compaired our result with erlier study to evaluate the benefits, outcome and prognosis of patients post-operatively. Conclusion: After pronator quadratus repair pain reduced in early postoperative period but pronation strength in early post- operative rehabilitation period could not be confirmed, And both the patients give satisfactory and almost similar results with full range of movements and early mobilization. We recommended to repair PQ muscle to protect flexor tendons. Keywords: Distal radius fracture, Volar plate, Pronator quadratus, Radius, Ellis plating, Volar barton’s fracture, Buttress plate.
Outcome of Cataract Surgery in Patients Treated for Retinopathy of Prematurity

Background/Aims: Pediatric patients with treated retinopathy of prematurity (ROP) may develop visually significant cataracts. We report the outcome of cataract surgery in patients who had ROP treatment. Method: Retrospective chart review of 19 eyes from 16 patients who had ROP treatment and subsequent cataract surgery between August, 2002 and March, 2015. Results: Eighteen of 19 eyes received laser treatment for ROP; 1 eye received intravitreal bevacizumab. 5 eyes received lens-sparing pars plana vitrectomy (LSPPV) in addition to laser. Average follow up was 10.1 ± 5.5 years. Average visual acuity improved from 20/324 prior to and 20/110 after cataract surgery (p = 0.06). 13/19 (68%) of the eyes received laser only and developed cataracts an average of 6.2 ± 5.6 years after laser treatment. 5/19 (26%) eyes developed cataracts an average of 6.4 ± 4.2 years after LSPPV and laser. In one eye, a cataract developed after a bevacizumab injection 2.9 years after the injection. Visual axis opacification (VAO) developed in 2/5 (40%) eyes after Ce/PCIOL/PPC-Antvx, 8/10 eyes (80%) after CE/IOL, and in 0/4 eyes after CE/PPC-AntVx. Ocular comorbidities included strabismus, nystagmus, amblyopia, optic atrophy, corneal band keratopathy, and phthisis bulbi. Conclusion: Cataract surgery in patients who have a history of ROP can be complicated by anatomical changes from prematurity and prior vitreoretinal surgeries. Vision improvement is limited by other ocular comorbidities.