Miracle-dz/UniFAR-FTUs huggingface dataset:
A randomized study of carbamazepine versus no medication after a first unprovoked seizure in childhood

We randomized 31 children with a 1st afebrile unprovoked seizure to receive carbamazepine (CBZ) or no medication for 1 year or until the time of a 2nd seizure. All seizures had a focal onset or were generalized tonicclonic. Overall, 2/14 randomized to CBZ and 9/17 with no medication had a recurrent afebrile seizure. Compliance with CBZ was excellent in 12/14, but noncompliance may have contributed to 1 of the recurrences with CBZ. Four discontinued CBZ because of side effects. Two additional children taking CBZ had a febrile seizure. Thus, only 6/14 taking CBZ had a year completely seizure-free with no unacceptable medication side effects. Of those taking no medication, 2 had a febrile recurrence, and 7/17 had a year completely-seizure free. Side effects and febrile recurrences may limit the value of CBZ for some children, although CBZ appears to reduce significantly recurrences after a 1st afebrile seizure.
Internal transfer of best practice for performance excellence: a global survey

Presents the findings of a global survey, undertaken by the European Centre for Total Quality Management (UK), which was aimed at identifying the critical success factors for the “effective internal transfer of best practices”. Overall, 227 organisations took part in the study. Participant organisations came from 32 different countries, all involved in benchmarking. The participants represented a wide cross‐section of organisational sectors ranging from non‐profit and government agencies to environmental management services and auto parts manufacturers. The survey shed light on the process and methodologies used by organisations to identify and evaluate best practices, and the process used for post‐implementation evaluation to assess the benefits gained. The results have highlighted the importance of “involvement” (training, ownership, and open communication) of all employees for the effective transfer of best practices. Concludes with an overview of the future issues that are expected to influence the spread and application of benchmarking and best practice transfer.
Fabrication and Optoelectronic Properties of Fluoride Tin Oxides/Porous Silicon/p-Silicon Heterojunction

In this paper, formation of a nanostructure semi transparence fluoride tin oxides (FTO) by spray pyrolysis technique on porous silicon PS layer. Porous silicon PS layer was prepared by anodization of p-type silicon wafers to fabricate of the UV- Visible Fluoride-doped tin oxide /Porous silicon /p-Si heterojunction photodetector. Optical properties of FTO thin films were measured. The optical band gap of 3.77 eV for SnO2:film was deduced. From (I-V) and (C-V) measurements, the barrier height for FTO/PS diode was of 0.77 eV, and the built in voltage , which was of 0.95 V. External quantum efficiency was 55 % at 500 nm which corresponding to peak responsivity of 1.15 A/W at 1 V bias. The PS band gap in the vicinity of PS/c-Si heterojunction was 1.38 eV.
Photosynthesis-Inhibiting Activity of 1-[(2-Chlorophenyl)carbamoyl]- and 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates †

Eight 1-[(2-chlorophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates and eight 1-[(2-nitrophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity of the compounds was relatively low; the corresponding IC50 values ranged from 0.05 to 0.664 mmol/L; and the highest activity within the series of compounds was observed for 1-[(2-chlorophenyl)-carbamoyl]naphthalen-2-yl propylcarbamate. It has been proven that the compounds are PET-inhibitors in photosystem II. Despite rather low PET-inhibiting activities, primary structure-activity trends can be discussed.
Gender Identification Moderates Social Identity Threat Effects on Working Memory

This investigation examined whether gender identification moderates women’s working memory following exposure to situations that threaten the integrity of their gender group. Young adults read sentences that either threatened women’s gender identity (in the social identity threat condition) or did not threaten this identity (in the control condition). During this sentence-reading task, participants were also asked to remember numerous neutral words. Women who were more strongly gender-identified recalled fewer of the neutral words when these words were presented in conjunction with sentences that threatened women’s gender identity compared to when the words were presented with non-identity threatening sentences. More weakly gender-identified women, as well as men, did not show working memory impairments when exposed to threatening as compared to nonthreatening sentences. This study provides insight into who is most vulnerable to experiencing working memory impairments following a threat to their social identity. It also has practical implications for promoting environments that increase the likelihood that members of devalued groups can more optimally draw on their reserves of memory. For instance, workplaces that permit the expression of sexism may find that this behavior actually decreases the performance of female employees who identify with their gender group.
Gender Asymmetries in Golf Participation

The golf industry in Portugal is facing substantial difficulties in keeping courses running—as is happening in the United States, for example—because the number of golf tourists and federate players has drastically decreased in recent years; from 17,642 players in 2005 to 14,679 in 2012 (European Golf Association, n.d.). Golf marketers and course owners have realized that this sector needs to undergo considerable changes to attract more clients to the game. Among potential clients, women are presently viewed as a segment that deserves attention since they can make a difference to the economy of the sector, which desperately needs to be enhanced. Nowadays, women tend to outlive men; they are more aware of the benefits of open-air activities and are willing to play, so golf could be a lifelong sport for them. Nevertheless, at present they only account for roughly 18% of golf players in Portugal (European Golf Association, n.d.).
Efficacy of TachoSil a fibrin-based haemostat in different fields of surgery- a systematic review

Background: Proper haemostasis is an important prerequisite for a successful outcome in all operative fields. TachoSil® is used in many surgical specialties, especially for diffuse bleeding. However, TachoSil is not only used for haemostasis but also for closure of other anatomical structures. Objective: To review the literature concerning the efficacy of TachoSil, a topical fibrin-based haemostat. Methods: PubMed was searched for data on TachoSil and TachoComb from clinical trials and basic research. Results/conclusion: TachoSil is used in many surgical specialties and has proven to be a valuable tool for several indications. It also seems to be cost effective. Solid data from randomized controlled trials are available for liver surgery, thoracic surgery and urology where a positive value is clearly documented.
A randomised, controlled, double‐blind trial of ultrasound‐guided phrenic nerve block to prevent shoulder pain after thoracic surgery

Moderate to severe ipsilateral shoulder pain is a common complaint following thoracic surgery. In this prospective, parallel‐group study at Odense University Hospital, 76 patients (aged > 18 years) scheduled for lobectomy or pneumonectomy were randomised 1:1 using a computer‐generated list to receive an ultrasound‐guided supraclavicular phrenic nerve block with 10 ml ropivacaine or 10 ml saline (placebo) immediately following surgery. A nerve catheter was subsequently inserted and treatment continued for 3 days. The study drug was pharmaceutically pre‐packed in sequentially numbered identical vials assuring that all participants, healthcare providers and data collectors were blinded. The primary outcome was the incidence of unilateral shoulder pain within the first 6 h after surgery. Pain was evaluated using a numeric rating scale. Nine of 38 patients in the ropivacaine group and 26 of 38 patients in the placebo group experienced shoulder pain during the first 6 h after surgery (absolute risk reduction 44% (95% CI 22–67%), relative risk reduction 65% (95% CI 41–80%); p = 0.00009). No major complications, including respiratory compromise or nerve injury, were observed. We conclude that ultrasound‐guided supraclavicular phrenic nerve block is an effective technique for reducing the incidence of ipsilateral shoulder pain after thoracic surgery.
Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency.

PURPOSE To evaluate the effect of lipofection, particle size, and surface coating on labeling efficiency of mammalian cells with superparamagnetic iron oxides (SPIOs). MATERIALS AND METHODS Institutional Review Board approval was not required. Different human cell lines (lung and breast cancer, fibrosarcoma, leukocytes) were tagged by using carboxydextran-coated SPIOs of various hydrodynamic diameters (17-65 nm) and a dextran-coated iron oxide (150 nm). Cells were incubated with increasing concentrations of iron (0.01-1.00 mg of iron [Fe] per milliliter), including or excluding a transfection medium (TM). Cellular iron uptake was analyzed qualitatively at light and electron microscopy and was quantified at atomic emission spectroscopy. Cell visibility was assessed with gradient- and spin-echo magnetic resonance (MR) imaging. Effects of iron concentration in the medium and of lipofection on cellular SPIO uptake were analyzed with analysis of variance and two-tailed Student t test, respectively. RESULTS Iron oxide uptake increased in a dose-dependent manner with higher iron concentrations in the medium. The TM significantly increased the iron load of cells (up to 2.6-fold, P < .05). For carboxydextran-coated SPIOs, larger particle size resulted in improved cellular uptake (65 nm, 4.37 microg +/- 0.08 Fe per 100 000 cells; 17 nm, 2.14 microg +/- 0.06 Fe per 100 000 cells; P < .05). Despite larger particle size, dextran-coated iron oxides did not differ from large carboxydextran-coated particles (150 nm, 3.81 microg +/- 0.46 Fe per 100 000 cells; 65 nm, 4.37 microg +/- 0.08 Fe per 100 000 cells; P > .05). As few as 10 000 cells could be detected with clinically available MR techniques by using this approach. CONCLUSION Lipofection-based cell tagging is a simple method for efficient cell labeling with clinically approved iron oxide-based contrast agents. Large particle size and carboxydextran coating are preferable for cell tagging with endocytosis- and lipofection-based methods.
Plant species protection contracts: modelling contract choice for specialised dairy farms and mixed dairy pig fattening farms in the Netherlands

Proposals of the European Commission stress the future importance of agri-environmental payments within the rural development policy of the European Union. The aim of this paper is to present and discuss a model for choice for plant species protection contracts in the Netherlands. The model includes transaction costs, time and the possibility of lock-in situations related to contract choice. The approach discussed is flexible because it makes it possible to introduce all kinds of technical and institutional restrictions (differences in contract design).
A Software Approach to Avoiding Spatial Cache Collisions in Parallel Processor Systems

In parallel processor systems, the performance of individual processors is a key factor in overall performance. Processor performance is strongly affected by the behavior of cache memory in that high hit rates are essential for high performance. Hit rates are lowered when collisions on placing lines in the cache force a cache line to be replaced before it has been used to best effect. Spatial cache collisions occur if data structures and data access patterns are misaligned. We describe a mathematical scheme to improve alignment and enhance performance in applications which have moderate-to-large numbers of arrays, where various dimensionalities are involved in localized computation and array access patterns are sequential. These properties are common in many computational modeling applications. Furthermore, the scheme provides a single solution when an application is targeted to run on various numbers of processors in power-of-two sizes. The applicability of the proposed scheme is demonstrated on testbed code for an air quality modeling problem.
Assessing nonprofit performance

The activities of nonprofit organizations are increasingly subject to performance evaluation. This chapter discusses the possibilities and limitations of using social benefit cost analysis as a framework for measuring nonprofit performance. Costâ€“benefit Analysis (CBA) and the closely related methodology of cost-effectiveness analysis (CEA) have become increasingly common means of evaluating the outcomes of a wide range of government regulations and public spending. Because there is considerable overlap between the outcomes that CBA is intended to measure and those that are the focus of a social return on investment (SROI) analysis, CBA offers a potentially useful framework for assessing non- profit performance. One pay-off from undertaking a CBA is that monetizing outcomes produces a single money metric that can facilitate comparisons among different program impacts. This feature of CBA, however, is also controversial, and both practical and conceptual objections have been raised to the monetization of nonprofit outcomes.
Structure-Based Methods for Selecting Fault-Detection-Strengthened FF under Multi-cycle Test with Sequential Observation

BIST based field testing is a promising way to guarantee the functional safety of intelligent and autonomous systems. To improve the fault coverage with less random patterns for BIST, sequentially observing some flip-flops(FFs) during multi-cycle test is useful. In this paper, we propose the methodology for selecting the Fault-Detection-Strengthened FFs in multi-cycle test by evaluating the structure of a circuit. The experimental results of ITC99 benchmarks and a real Electronic Control Unit (ECU) circuit show the effectiveness of the proposed methods in fault coverage improvement and random pattern reduction.
Hydrogen generation using nitride photoelectrode

We developed nitride photoelectrodes to produce hydrogen from water. GaN can split water into hydrogen and oxygen as a photocatalyst with no extra bias applied. The irradiated photon-to-current conversion efficiency was as high as 60-70% in the wavelength region below its bandgap. We confirmed good stability and high efficiency of a GaN photoelectrode.
In‐vivo platelet activation correlates with red cell anionic phospholipid exposure in patients with β‐thalassaemia major

Several clinical and laboratory findings suggest the presence of a chronic hypercoagulable state in patients with β‐thalassaemia major (TM). We have previously shown that isolated TM red blood cells (RBC) strongly enhance prothrombin activation, suggesting an increased membrane exposure of procoagulant phospholipids (i.e. phosphatidylserine). In this study we quantitated the procoagulant activity of RBC in TM and thalassaemia intermedia (TI) patients. We also determined the fraction of activated platelets expressing p‐selectin (CD62p) or CD63 in these subjects. Both assays were performed by dual‐colour flow cytometry. A significantly (P < 0.01) higher fraction of FITC‐annexin V‐labelled RBC was found in TM and TI patients, compared to the controls. A highly significant correlation (P < 0.001) was found in TM patients between the number of RBC‐bound annexin V molecules and the fraction of CD62p (p‐selectin) or CD63‐positive platelets. This association between annexin V binding to TM RBC and the expression of platelet activation markers was also found in individual TM patients over time. Thus, the procoagulant surface of TM RBC may accelarate thrombin generation in vivo which, in turn, triggers platelet activation.
Country Effects on CRM Success

Abstract Customer relationship management (CRM) adoption is growing at a dramatic pace in firms and is significantly impacting customer and business market behaviors. As a result, most firms have started developing and implementing CRM strategies. However, country effects on CRM strategy outcomes in international environments have not been discussed and are the focus of this paper. In this paper, we examine the impacts of marketing infrastructure and marketing institutions on the development of CRM strategies and success in the implementation of such strategies. Our framework has utility in understanding the impacts of country-specific factors in the outcomes of CRM Strategy.
Unmanned aerial vehicle path planning problem by adjusted elephant herding optimization

Unmanned aerial vehicle path planning is a high dimensional NP-hard problem. It is related to optimizing the flight route subject to various constraints inside the battlefield environment. Since the number of control points is large the traditional methods could not produce acceptable results when tackling this problem. Elephant herding optimization algorithm is one of the recent swarm intelligence algorithms which has not been sufficiently researched. In this paper we have adjusted the elephant herding optimization algorithm for the unmanned aerial vehicle path planning problem. We tested our approach using parameters of the battlefield environments from the literature and the comparative analysis has shown that our adjusted elephant herding optimization algorithm outperformed other approaches from the literature.
Liquidity Risk in Banking : Is there Herding?

Banks individually optimize their liquidity risk management, often neglecting the externalities generated by their choices on the overall risk of the financial system. This is the main argument to support the regulation of liquidity risk. However, there may be incentives, related for instance to the role of the lender of last resort, for banks to optimize their choices not strictly at the individual level, but engaging instead in collective risk taking strategies, which may intensify systemic risk. In this paper we look for evidence of such herding behaviors, with an emphasis on the period preceding the global financial crisis. Herding is significant only among the largest banks, after adequately controlling for relevant endogeneity problems associated with the estimation of peer effects. This result suggests that the regulation of systemically important financial institutions may play an important role in mitigating this specific component of liquidity risk.
Limbic Ictus and Atypical Psychoses

This paper reviews the data which support the concept of a limbic ictus as an etiological mechanism in many patients with diagnoses of atypical psychoses. Inasmuch as our clinical neurophysiological techniques cannot easily record this limbic ictus, much of these data are circumstantial. Furthermore, lacking reliable biological markers for the major psychoses, supporting animal data rests on the tenuous identification of psychoses in terms of behavioral observation on these animals, whereas our psychiatric diagnostic criteria for psychoses depend largely on the verbal reports of our patients. There is, however, direct empirical support for this concept which is limited to a small cohort whose psychoses were correlated with electrographic data recorded from chronically implanted subcortical electrodes. These data include not only observations of spontaneously appearing ictal or interictal patterns but also observations following electrical stimulation of subcortical structures. The kindling phenomena induced by such electrical stimulation in animals have also been observed in humans. Kindling then offers a theoretical framework within which to view more prolonged behavioral deviations as neurophysiological processes, although it is still not completely clear whether such deviations are correlated with ictal or interictal phenomena. Some drugs such as cocaine and amphetamine reduce seizural thresholds within the limbic system, and hence facilitate kindling. In fact, some of the neuroleptics and tricyclics now utilized in the treatment of not only the major psychoses but also the atypical psychoses also lower seizural thresholds. This may explain why such drugs often exaggerate rather than ameliorate the symptoms of atypical psychoses. Furthermore, this means that drugs which raise seizural thresholds could be an important addition to our therapeutic armamentarium. This has been particularly demonstrated by the use of the anticonvulsant carbamazepine. Animal studies have shown that this drug is particularly effective in blocking the kindling phenomena in the amygdala. It is still not clear whether the therapeutic effectiveness of carbamazepine in treating the atypical psychoses is due to its anticonvulsant properties or some other action on synaptic neurotransmission with the elevation in seizural threshold as an incidental consequence with regard to the drug's effectiveness in the atypical psychoses.
Increased CDA expression / activity in males contributes to decreased cytidine analogue half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapy Running title : Gender , cytidine deaminase and 5-aza / decitabine

1 Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 2 NCTT, Division of Pre-Clinical Innovations, National Center for Advancing Translational Sciences, NIH, Bethesda, Maryland Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and diagnosis, NCI, NIH , Bethesda, Maryland 4 College of Pharmacy, The Ohio State University, Columbus, Ohio 5 AVANZA Laboratories, Gaithersburg, Maryland 6 Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 7 Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio
Wastewater Reclamation and Reuse

In Mediterranean area, several counties are regularly facing significant water demand and supply imbalances, particularly in the summer period, due to simultaneous occurrence of low precipitation, high evaporation and increased demands for irrigation and tourism. As the demand for water is constantly increasing and drought problems become more important, implementation of wastewater reclamation and reuse practices should be developed, in order to conserve and even extend water resources and constrain contamination of aquifers by seawater or wastewater and coastal water pollution. One of the objectives of ManWater Project was the investigation of the wastewater treatment potential in the context of reclamation and reuse of wastewater produced in the target areas. The application of an integrated wastewater management was evaluated aiming for the protection of water environment as well as for the conservation of water resources of the target areas. The wastewater reuse applications that were suggested included the agricultural and landscape irrigation and the enrichment of the groundwater bodies. Various collective data were evaluated including the wastewater treatment and disposal needs, assessment of the available water resources and the water demand as well as the analysis of the environmental and financial benefits resulting from a specific reuse application. Public acceptance was also evaluated by means of a questionnaire addressed to four different groups of people directly or indirectly affected by the water reclamation and reuse. These groups comprised tourists either from Greece or from abroad and entrepreneurs either native or temporal habitants.