Miracle-dz/UniFAR-FTUs huggingface dataset:
Congenital Lung Malformations: Unresolved Issues and Unanswered Questions

Advances in prenatal and postnatal diagnosis, perioperative management, and postoperative care have dramatically increased the number of scientific reports on congenital thoracic malformations (CTM). Nearly all CTM are detected prior to birth, generally by antenatal ultrasound. After delivery, most infants do well and remain asymptomatic for a long time. However, complications may occur beyond infancy, including in adolescence and adulthood. Prenatal diagnosis is sometimes missed and detection may occur later, either by chance or because of unexplained recurrent or persistent respiratory symptoms or signs, with difficult implications for family counseling and substantial delay in surgical planning. Although landmark studies have been published, postnatal management of asymptomatic children is still controversial and needs a resolution. Our aim is to provide a focused overview on a number of unresolved issues arising from the lack of an evidence-based consensus on the management of patients with CTM. We summarized findings from current literature, with a particular emphasis on the vigorous controversies on the type and timing of diagnostic procedures, treatments and the still obscure relationship between CTM and malignancies, a matter of great concern for both families and physicians. We also present an algorithm for the assessment and follow-up of CTM detected either in the antenatal or postnatal period. A standardized approach across Europe, based on a multidisciplinary team, is urgently needed for achieving an evidence-based management protocol for CTM.
Eating Behavior and the Evolutionary Perspective on Anorexia Nervosa

On the standard perspective, anorexia nervosa and other eating disorders are caused by genetically determined, neurochemically mediated mental illnesses. Standard treatment, cognitive behavioral therapy (CBT), targets cognitive processes thought to maintain the disorders. Effective neurochemically based treatments are not available and the rate of remission is ≤25% 1 year after CBT, with unknown outcomes in the long-term. With starvation as the major threat in biological history, the evolutionary perspective focuses on foraging for food and eating behavior. A neural network, including hypothalamic arcuate peptide-neurons, brainstem serotonin- and dopamine-neurons and their prefrontal cortical projections, mediates (rather than controls) the behavioral adaptations to variations in food availability; activation of the network is associated with opposing behavioral outcomes depending upon external variations. In the clinic, the control of eating behavior is therefore outsourced to a machine that provides feedback on how to eat. Hundreds of eating disorders patients have recovered by practicing eating; the rate of remission is 75% in on average 1 year of treatment, the rate of relapse is 10% over 5 years of follow-up and no patient has died. A two-parameter asymptotic exponential growth curve modeled the eating behavior of 17 healthy women but not that of 17 women with anorexia nervosa. When in remission, the eating behavior of the anorexic women approached that of the healthy women. It is suggested that the treatment of eating disorders should focus on eating behavior.
Engagement and Weight Loss: Results from the Mobile Health and Diabetes Trial.

Background: Prevalence of type 2 diabetes (T2D) is increasing worldwide. Identifying and targeting individuals at high risk, is essential for preventing T2D. Several studies point to mobile health initiatives delivered through personal smart devices being a promising approach to diabetes prevention, through weight loss. The aim of the mobile health and diabetes (mDiab) trial was twofold: to achieve 5% weight loss and to look at the association of weight loss with degree of engagement with the mDiab app. Methods: The mDiab randomized control trial was carried out among smartphone users who are at high risk for T2D mellitus in three cities-Chennai, Bengaluru, and New Delhi in India. The intervention was delivered through a mobile phone application along with weekly coach calls for 12 weeks. While individuals in the intervention group individuals received the app, which enabled tracking their weight, physical activity, and diet along with 12 weekly video lessons on T2D prevention and coach calls, the control group received usual care. Results: The intervention group experienced a significant 1 kg weight loss while the control group lost 0.3 kg (P < 0.05). More individuals in the intervention group (n = 139, 15%) met the 5% weight loss target than in the control group (n = 131, 9%). In the intervention group those who viewed the videos experienced greater weight loss (2.4 kg) than those who only attended coach calls (0.9 kg) (P < 0.01). Conclusions: An mHealth intervention helped to achieve moderate weight loss. Future studies should explore the sustainability of this weight loss.
A 14.8 dBm 20.3 dB Power Amplifier for D-band Applications in 40 nm CMOS

This paper presents a high output power, high gain, class-AB power amplifier (PA) in 40 nm CMOS technology for D-band applications. Two-way transformer-based power-combining is implemented in order to increase output power. The supply voltage of the designed PA is 1 V. The PA achieves a PSAT of 14.8 dBm, small-signal gain of 20.3 dB and maximum PAE of 8.9 % at 140 GHz.
Termination of oblivious chase is undecidable

We show that all--instances termination of chase is undecidable. More precisely, there is no algorithm deciding, for a given set $\cal T$ consisting of Tuple Generating Dependencies (a.k.a. Datalog$^\exists$ program), whether the $\cal T$-chase on $D$ will terminate for every finite database instance $D$. Our method applies to Oblivious Chase, Semi-Oblivious Chase and -- after a slight modification -- also for Standard Chase. This means that we give a (negative) solution to the all--instances termination problem for all version of chase that are usually considered. The arity we need for our undecidability proof is three. We also show that the problem is EXPSPACE-hard for binary signatures, but decidability for this case is left open. Both the proofs -- for ternary and binary signatures -- are easy. Once you know them.
Thermal Expansion Coefficient of Monolayer Molybdenum Disulfide Using Micro-Raman Spectroscopy.

Atomically thin two-dimensional (2D) materials have shown great potential for applications in nanoscale electronic and optical devices. A fundamental property of these 2D flakes that needs to be well characterized is the thermal expansion coefficient (TEC), which is instrumental to the dry transfer process and thermal management of 2D material-based devices. Yet, most of current studies of 2D materials' TEC extensively rely on simulations due to the difficulty of performing experimental measurements on an atomically thin, micron-sized, and optically transparent 2D flake. In this work, we present a three-substrate approach to characterize the TEC of monolayer molybdenum disulfide (MoS2) using micro-Raman spectroscopy. The temperature dependence of the Raman peak shift was characterized with three different substrate conditions, from which the in-plane TEC of monolayer MoS2 was extracted based on lattice symmetries. Independently from two different phonon modes of MoS2, we measured the in-plane TECs as (7.6±0.9)×10-6 1/K and (7.4±0.5)×10-6 1/K, respectively, which are in good agreement with previously reported values based on first principle calculations. Our work is not only useful for thermal mismatch reduction during material transfer or device operation, but provides a general experimental method that does not rely on simulations to study key properties of 2D materials.
Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis

The control of cell fate through oriented cell division is imperative for proper organ development. Basal epidermal progenitor cells divide parallel or perpendicular to the basement membrane to self-renew or produce differentiated stratified layers, but the mechanisms regulating the choice between division orientations are unknown. Using time-lapse imaging to follow divisions and fates of basal progenitors, we find that mouse embryos defective for the planar cell polarity (PCP) gene, Vangl2, exhibit increased perpendicular divisions and hyperthickened epidermis. Surprisingly, this is not due to defective Vangl2 function in the epidermis, but to changes in cell geometry and packing that arise from the open neural tube characteristic of PCP mutants. Through regional variations in epidermal deformation and physical manipulations, we show that local tissue architecture, rather than cortical PCP cues, regulates the decision between symmetric and stratifying divisions, allowing flexibility for basal cells to adapt to the needs of the developing tissue.
Comparing musicians and non-musicians in signal-in-noise perception

Abstract Objectives: The objective is to compare musicians and non-musicians in signal-in-noise perception.Design: Participants underwent the following tests: (1) High-frequency (HF) audiometry, (2) QuickSIN (a test for speech perception in noise), and (3) Binaural Masking Level Difference (BMLD) test (a test that examines the hearing threshold of a low-frequency tone from noise masking when the phase of the signal or noise in one ear is reversed with respect to the phase of the signal or noise in the other ear, i.e. the difference in the threshold for detection of the tone in noise under the SπNo and SoNo conditions). Study sample: Thirty-four healthy young normal-hearing listeners including 17 musicians (M) and 17 non-musicians (NM). Results: There were no study group difference in HF audiometry and QuickSIN. The M group had a significantly better performance under the SoNo but not under the SπNo condition. As a result, the BMLD value (SoNo–SπNo) was significantly smaller in the M group than in the NM group.Conclusions: There is a musicians’ advantage in binaural tone-in-noise detection in the BMLD task under the SoNo condition, suggesting that long-term music training positively shapes the auditory system.
Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease.

The role of non-invasive positive pressure ventilation (NIV) in severe COPD has been controversial. Over the last two decades, data primarily obtained from Europe have begun to define the clinical characteristics of patients likely to respond, the role of high intensity NIV and the potential best timing of initiating therapy. These approaches, however, have not been validated in the context of the United States healthcare delivery system. Use of NIV in severe COPD in the United States is limited by the practicalities of doing in-hospital titrations as well as a complex system of reimbursement. These systematic complexities coupled with a still emerging clinical trials database regarding the most effective means to deliver NIV have led to a persistent uncertainty of when in stable severe COPD treatment with NIV is actually appropriate. In this concise review, we propose an assessment algorithm and treatment plan that can be used in clinical practice in the United States, but acknowledge that the absence of pivotal clinical trials largely precludes a robust evidence-based approach to this potentially valuable therapy.
The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

Accumulation of advanced glycation end products (AGEs) promotes the generation of free radicals, which leads to chronic oxidative stress predisposing to chronic oxidative stress, inflammation, and related diseases. This systematic review aimed to determine the effect of resveratrol (RSV) on AGE‐induced toxicity and its deleterious consequences. A comprehensive search was performed through literature were published until December 2018 using relevant keywords. The databases that were used for the search were PubMed, Scopus, Embase, ProQuest, and Google Scholar. A total of 29 eligible studies were found and included in the review for the analysis. Except one, all studies showed suppressing effects for RSV on the production of AGEs or receptor for advanced glycation end products (RAGE) and its detrimental consequences including oxidative stress, inflammatory response, cellular immune reactions, insulin response, and atherosclerosis. RSV exerts its effects through influencing RAGE, nuclear factor kappa B (NF‐κB), peroxisome proliferator‐activated receptor (PPAR) γ, and transforming growth factor (TGF)‐β activities. This review suggests that RSV has got potential to decrease AGEs toxicity and inhibit the AGE‐induced complications. More clinical trials are suggested to evaluate the beneficial effect of RSV on AGEs in chronic metabolic diseases.
Naringenin palliates cisplatin and doxorubicin gonadal toxicity in male rats

Abstract Cisplatin (CP) and doxorubicin (DX) can cause testicular injury by inducing oxidative/nitrosative stress, inflammation, and apoptosis, Naringenin (NG) has antioxidant, antinitrative, anti-inflammatory, and anti-apoptotic effects. This study investigated the potential ability of NG to block gonadotoxicity induced CP and DX in male rats. The rats received one injection of either CP (10 mg/kg, i.p.) or DX (15 mg/kg, i.p.), and treated with NG (50 mg/kg/day, p.o.) for 10 days beginning 6 days prior to CP and DX administration. NG significantly prevented the decreases of serum testosterone and inhibin B in rats received CP and DX. Additionally, NG significantly decreased the elevated testicular malondialdehyde, tumor necrosis factor-α/interleukin-10 ratio, and caspase-3 in CP- and DX-treated rats. NG also significantly raised the decreased testicular Bcl-2/Bax ratio, and total antioxidant status in CP- and DX-challenged rats. In addition, NG significantly increased P-glycoprotein level in testes of rats received CP and DX. Moreover, NG significantly decreased the testicular histopathological injury, and immunohistochemical expression of inducible nitric oxide synthase induced by CP and DX in rat testes. It was concluded that NG impeded gonadotoxicity of CP and DX in male rats by mitigating oxidative stress, nitrosative stress, inflammation, and apoptosis.
Realization of breast tissue-mimicking phantom materials: dielectric characterization in the 0.5-50 GHz frequency range

Breast cancer is the most widespread disease among women around the world. However, thanks to the improvement in knowledge about cancer, it is becoming more treatable and curable. In recent years, the interest toward the use of radiofre-quencies for diagnostic and screening purposes has been growing, with particular attention for microwaves and mm-waves. These frequencies in principle give the possibility of making a diagnosis without risks and involving low cost instrumentation. Past dielectric characterizations of human breast samples have shown that a significant difference is present between healthy and malignant tissues, and that a reasonable penetration depth is possible for detecting a cancer of some millimeters, even in the mm-wave frequency range. A fundamental step toward the development of these systems is the test phase on breast phantoms. Several tissue-mimicking materials have been proposed, but the presence of a number of drawbacks is pushing the research for different agents and/or mixtures to be used for this purpose. In this paper, the dielectric characterization of easy-to-produce and cheap mixtures mimicking the dielectric properties of human breast healthy tissues up to 50 GHz is presented. Similar mixtures are currently used for ultrasound breast phantoms, and so far they have been unexplored in the radiofrequency regime. All measurements have been compared to the data derived from the dielectric characterization of human breast samples, and the good agreement between them shows that they could be an excellent alternative to the current tissue mimicking materials.
Structural Evolution in Isothermal Crystallization Process of Poly(L-lactic acid) Enhanced by Silk Fibroin Nano-Disc

The nucleating effect of silk fibroin nano-disc (SFN) on the crystallization behavior of poly(L-lactic acid) (PLLA) was investigated by simultaneous synchrotron small- and wide-angle X-ray scattering measurements. For the isothermal crystallization at 110 °C from the melt, the induction period of the PLLA specimens containing 1% SFN was reduced compared to that of the neat specimens, indicating the acceleration of the nucleation of PLLA. The final degree of crystallinity was also increased, and the crystallization half-time was decreased, which indicates that the overall crystallization process was accelerated. Furthermore, the final value of the crystallite size (the lateral size of the crystalline lamella) was slightly lower for the specimens containing 1% SFN than that for the PLLA neat specimen, although the crystallites started growing much earlier. However, it was found that there was no effect of SFN on the growth rate of the crystallite size. The lamellar thickening process was also accelerated with a clear overshooting phenomenon with the inclusion of 1% SFN. As for the polymorphism, the α’ phase is dominant with about 96%, but a small amount of the α phase (4%) is found to exist. It was found that the SFN can also accelerate the formation of the minor α phase as well as the major α’ phase.
Height Gain and Safety Outcomes in Growth Hormone-Treated Children with Idiopathic Short Stature: Experience from a Prospective Observational Study

Background/Objectives: Growth hormone (GH) treatment of idiopathic short stature (ISS) received US Food and Drug Administration approval in 2003. We assessed height gain and safety in 2,450 children with ISS treated with GH in US clinical practice. Methods: Short-term height gain, near-adult height (NAH), and safety outcomes were investigated using Genetics and Neuroendocrinology of Short Stature International Study data. Results: Compared to children with isolated idiopathic GH deficiency (IGHD), those with ISS were shorter at baseline but had similar age and GH dose. Mean ± SD height SD score (SDS) increase was similar for ISS and IGHD, with 0.6 ± 0.3 (first), 0.4 ± 0.3 (second), 0.3 ± 0.3 (third), and 0.1 ± 0.3 (fourth year) for ISS. Girls with ISS (27% of subjects) were younger and shorter than boys but had similar height gain over time. At NAH in the ISS group (n = 467), mean ± SD age, GH duration, and height SDS were 17.3 ± 2.3 years, 4.6 ± 2.7 years, and –1.2 ± 0.9, respectively. Height gain from baseline was 1.1 ± 1.0 SDS and was greater for boys than girls (1.2 ± 1.0 vs. 0.9 ± 0.9), but boys were treated longer (5.1 ± 2.8 vs. 3.6 ± 2.5 years). Adverse events were reported for 24% with ISS versus 20% with IGHD – most were common childhood conditions or previously reported in GH-treated patients. Conclusions: GH-treated children with ISS achieved substantial height gain, similar to patients with IGHD. Fewer GH-treated girls were enrolled than boys, but with similar height SDS gain over time. No ISS-specific safety issues were identified. Thus, GH treatment of ISS appears to have a safety/effectiveness profile similar to that of IGHD.
Insect ATP-Binding Cassette (ABC) Transporters: Roles in Xenobiotic Detoxification and Bt Insecticidal Activity

ATP-binding cassette (ABC) transporters, a large class of transmembrane proteins, are widely found in organisms and play an important role in the transport of xenobiotics. Insect ABC transporters are involved in insecticide detoxification and Bacillus thuringiensis (Bt) toxin perforation. The complete ABC transporter is composed of two hydrophobic transmembrane domains (TMDs) and two nucleotide binding domains (NBDs). Conformational changes that are needed for their action are mediated by ATP hydrolysis. According to the similarity among their sequences and organization of conserved ATP-binding cassette domains, insect ABC transporters have been divided into eight subfamilies (ABCA–ABCH). This review describes the functions and mechanisms of ABC transporters in insecticide detoxification, plant toxic secondary metabolites transport and insecticidal activity of Bt toxin. With improved understanding of the role and mechanisms of ABC transporter in resistance to insecticides and Bt toxins, we can identify valuable target sites for developing new strategies to control pests and manage resistance and achieve green pest control.
Environmental Risk Assessment of Metals in the Volcanic Soil of Changbai Mountain

Tianchi volcano is a dormant active volcano with a risk of re-eruption. Volcanic soil and volcanic ash samples were collected around the volcano and the concentrations of 21 metals (major and trace elements) were determined. The spatial distribution of the metals was obtained by inverse distance weight (IDW) interpolation. The metals’ sources were identified and their pollution levels were assessed to determine their potential ecological and human health risks. The metal concentrations were higher around Tianchi and at the north to the west of the study area. According to the geo-accumulation index (Igeo), enrichment factor (EF) and contamination factor (CF) calculations, Zn pollution was high in the study area. Pearson’s correlation analysis and principal component analysis showed that with the exception of Fe, Mn and As, the metals that were investigated (Al, K, Ca, Na, Mg, Ti, Cu, Pb, Zn, Cr, Ni, Ba, Ga, Li, Co, Cd, Sn, Sr) were mostly naturally derived. A small proportion of Li, Pb and Zn may have come from vehicle traffic. There is no potential ecological risk and non-carcinogenic risk because of the low concentrations of the metals; however, it is necessary to pay attention to the carcinogenic risk of Cr and As in children.
Controlling fracture cascades through twisting and quenching

Significance Fracture processes are ubiquitous in nature, from earthquakes to broken trees and bones. Understanding and controlling fracture dynamics remain one of the foremost theoretical and practical challenges in material science and physics. A well-known problem with direct implications for the fracture behavior of elongated brittle objects, such as vaulting poles or long fibers, goes back to the famous physicist Richard Feynman who observed that dry spaghetti almost always breaks into three or more pieces when exposed to large bending stresses. While bending-induced fracture is fairly well understood nowadays, much less is known about the effects of twist. Our experimental and theoretical results demonstrate that twisting enables remarkable fracture control by using the different propagation speeds of twist and bending waves. Fracture fundamentally limits the structural stability of macroscopic and microscopic matter, from beams and bones to microtubules and nanotubes. Despite substantial recent experimental and theoretical progress, fracture control continues to present profound practical and theoretical challenges. While bending-induced fracture of elongated rod-like objects has been intensely studied, the effects of twist and quench dynamics have yet to be explored systematically. Here, we show how twist and quench protocols may be used to control such fracture processes, by revisiting Feynman’s observation that dry spaghetti typically breaks into three or more pieces when exposed to large pure bending stresses. Combining theory and experiment, we demonstrate controlled binary fracture of brittle elastic rods for two distinct protocols based on twisting and nonadiabatic quenching. Our experimental data for twist-controlled fracture agree quantitatively with a theoretically predicted phase diagram, and we establish asymptotic scaling relations for quenched fracture. Due to their general character, these results are expected to apply to torsional and kinetic fracture processes in a wide range of systems.