Miracle-dz/UniFAR-FTUs huggingface dataset:
Vitamin D level among patients with non specific musculoskeletal pain attending tertiary care hospital in Tamil Nadu

Introduction: In adult sequelae of vitamin D deficiency involve the musculoskeletal system leading to proximal muscle weakness, bone pain, and osteomalacia which is largely unrecognized by both physicians and patients. Objective: determining the prevalence of vitamin D (<20ng/dl) deficiency among patients attending the orthopedic outpatient department in tertiary care hospital with complaints of non-specific symptoms of body pain and low back pain without any other co morbid condition. Methodology: A cross sectional study was conducted among 281 adult patients above the age 20 years attending orthopedic department of a tertiary care hospital with non-specific complaints of general body pain/back pain/tiredness/weakness on working and walking with no other symptoms such as injury, fever, GIT problems or known medical illness and no relief of the pain symptoms with routine treatments with analgesics and rest and physiotherapy were screened for Vitamin D levels when other routine test such as complete blood count, ESR, BI, sugar, RFT were normal. Results: out of 281 patients tested, 201 (71.5%) of the study population had below normal vitamin D of them 40.2% had deficiency, 31.3% had insufficiency and 28.5 had sufficient vitamin D level. The proportion of patients Vitamin D deficiency and insufficiency w as higher in the age group 20-39 compared to other age group and it was found statically significant (p=0.01). Conclusion: Importance has to be given to adequate vitamin D supplementation in the patents vitamin D deficiency
Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model

Therapeutical approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Repurposing FDA approved drugs like fingolimod (FTY720) for treatment of AD is a promising way to reduce the time to bring such medication into clinical practice. Previous studies in AD mouse models suggested that physical exercise or changed lifestyle can delay AD related synaptic and memory dysfunctions when treatment started in juvenile animals long before onset of disease symptoms. Here, we addressed whether the FDA approved drug fingolimod rescues AD related synaptic deficits and memory dysfunction in an APP/PS1 AD mouse model when medication starts after onset of symptoms (at 5 months). Male mice received intraperitoneal injections of fingolimod for 1-2 months starting at 5-6 months. This treatment rescued spine density as well as long-term potentiation in hippocampal CA1 pyramidal neurons, and ameliorated dysfunctional hippocampus-dependent memory that was observed in untreated APP/PS1 animals at 6-7 months of age. Immunohistochemical analysis with markers of microgliosis (Iba1) and astrogliosis (GFAP) revealed that our fingolimod treatment regime strongly down regulated neuro-inflammation in the hippocampus and cortex of this AD model. These effects were accompanied by a moderate reduction of Aβ accumulation in hippocampus and cortex. Our results suggest that fingolimod, when applied after onset of disease symptoms in an APP/PS1 mouse model, rescues synaptic pathology and related memory performance deficits observed in untreated AD mice, and that this beneficial effect is mediated via anti-neuroinflammatory actions of the drug on microglia and astrocytes.
Development of edible packaging film from banana peels and effect of glycerol concentration on the film properties

Edible film from banana peel was developed with incorporation of varying levels of glycerol (5, 10, 15 and 20%) as plasticizers. Different parameters including thickness of the edible film, moisture content of the film by hot air oven method, tearing strength, density, water absorption, solubility, water vapor transmission rate(WVTR) and color were studied. The study shows the best result at 10% glycerol concentrations.
Simulation haute performance des suspensions de fibres courtes pour les procédés de fabrication de composites

La simulation numerique directe constitue un outil precis pour la comprehension des mecanismes d’orientation dans les suspensions chargees de fibres courtes. L’objectif est de mettre en place un outil de simulation directe permettant de predire d’une maniere fiable la microstructure d’une piece issue du procede d’injection. Un passage a l’echelle enrheometrie numerique est envisage afin d’etudier le probleme dans sa globalite et de se passer des hypotheses limitatrices reliees au choix des volumes elementaires representatifs. Un algorithme de generation de microstructures isotropes ou orientees a ete implemente permettant de generer, dans un temps optimise, des millions de fibres. Un ecoulement de Stokes a ete applique a une suspension de 10 000 fibres et les equations ont ete traitees par une methode elements finis associee a une formulation multi domaines et un maillage adaptatif. Ensuite, l’etude du mouvement des fibres a ete initiee a travers l’etude d’une fibre dans un ecoulement de cisaillement.
Team LSTM : player trajectory prediction in basketball games using graph-based LSTM networks

Autonomous systems deployed in human environments must have the ability to understand and anticipate the motion and behavior of dynamic targets. More specifically, predicting the future positions of agents and planning future actions based on these predictions is a key component of such systems. This is a challenging task because the motion behavior of each agent not only depends on its own goal intent, but also the presence and actions of surrounding agents, social relations between agents, social rules and conventions, and the environment characteristics such as topology and geometry. We are specially interested in the problem of human motion trajectory prediction in real-world, social environments where potential interactions affect the way people move. One such environment is a basketball game with dynamic and complex movements driven by various social interactions. In this work, we focus on player motion trajectory prediction in real basketball games. We view the problem of trajectory prediction as a sequence prediction task where our goal is to predict the future positions of players using their past positions. Following the success of recurrent neural network models for sequence prediction tasks, we investigate the ability of these models to predict motion trajectories of players. More specifically, we propose a graph-based pooling procedure that uses relation networks and incorporates it with long short-term memory networks. We study the effect of different graph structures on the accuracy of predictions. We evaluate the different variations of our model on three datasets; two publicly available pedestrian datasets of ETH and UCY, as well as a real-world basketball dataset. Our model outperforms vanilla LSTM and Social-LSTM baselines on both of these datasets.
Contribution of local and remote anthropogenic aerosols to a record-breaking torrential rainfall event in Guangdong Province, China

Abstract. A torrential rainfall case, which happened in Guangdong Province during 14–16 December 2013, broke the historical rainfall record in the province in terms of duration, affected area, and accumulative precipitation. The influence of anthropogenic aerosols on this extreme rainfall event is examined using a coupled meteorology–chemistry–aerosol model. Up to 33.7 mm precipitation enhancement in the estuary and near the coast is mainly attributed to aerosol–cloud interactions (ACI), whereas aerosol–radiation interaction partially offsets 14 % of the precipitation increase. Our further analysis of changes in hydrometeors and latent heat sources suggests that the ACI effects on the intensification of precipitation can be divided into two stages: cold rain enhancement in the former stage followed by warm rain enhancement in the latter. Responses of precipitation to the changes in anthropogenic aerosol concentration from local (i.e., Guangdong Province) and remote (i.e., outside Guangdong Province) sources are also investigated through simulations with reduced aerosol emissions from either local or remote sources. Accumulated aerosol concentration from local sources aggregates mainly near the ground surface and dilutes quickly after the precipitation initiated. By contrast, the aerosols from remote emissions extend up to 8 km above ground and last much longer before decreasing until peak rainfall begins, because aerosols are continuously transported by the strong northerly winds. The patterns of precipitation response to remote and local aerosol concentrations resemble each other. However, compared with local aerosols through warm rain enhancement, remote aerosols contribute more than twice the precipitation increase by intensifying both cold and warm rain, occupying a predominant role. A 10-time emission sensitivity test shows about 10 times the PM2.5 concentration compared with the control run. Cold (warm) rain is drastically enhanced (suppressed) in the 10× run. In response to 10× aerosol emissions, the pattern of precipitation and cloud property changes resembles the differences between CTL and CLEAN, but with a much greater magnitude. The precipitation average over Guangdong decreases by 1.0 mm in the 10× run but increases by 1.4 mm in the control run compared with the CLEAN run. We note that the precipitation increase is concentrated within a more narrowed downstream region of the aerosol source, whereas the precipitation decrease is more dispersed across the upstream region. This indicates that the excessive aerosols not only suppress rainfall, but also change the spatial distribution of precipitation, increasing the rainfall range, thereby potentially exacerbating flood and drought elsewhere. This study highlights the importance of considering aerosols in meteorology to improve extreme weather forecasting. Furthermore, aerosols from remote emissions may outweigh those from local emissions in the convective invigoration effect.
Kampanye Moderasi Beragama di Facebook: Bentuk dan Strategi Pesan

This paper seeks to formulate an ideal concept in campaigning for religious moderation in Indonesia through the use of Facebook. There are three things that underlie this study, 1) The mass movement of radicalism in the name of religion in Social Media; 2) Potential conflicts on the basis of SARA; 3) The importance of efforts to strengthen religious moderation in Indonesia based on social media. The idea of religious moderation must be strengthened by the national movement. The library research method (library study) becomes the scientific foundation for exploring various literature, both primary and secondary related to the concept of religious moderation in Indonesia. The results of this study offer a message form and strategy in campaigning for religious moderation on Facebook. First, the form of a religious moderation campaign on Facebook must be ideologically-oriented (oriented towards changing attitudes, behavior and public views). Second, campaign messages must be informative and persuasive (based on data and facts) and can influence other Facebook users to participate in creating campaigns (social campaigns) on religious moderation. A religious moderation campaign message on Facebook does not necessarily have to content writing, it can also be an illustrative (animated) picture or a short educational video.
Current progress in the study of acute myeloid leukemia

In recent years the rate of malignant diseases has been growing rapidly around the world. The Republic of Kazakhstan, according to international statistics, refers to the countries with moderately high cancer incidence and mortality. Every year approximately thirty thousand Kazakhstani people are diagnosed with cancer. In 2018, 35,753 patients were registered in the country, of which 44.3% were men and 55.7% were women. Cancer mortality over the same period amounts to about 15,000 lives. The cancer incidence rate increased by 8% from 181.2 (in 1999) to 195.7 per 100,000 population in 2019 [1]. Blood cancers are relatively rare diseases but, nevertheless, in Kazakhstan about 7,000 patients with hematopoietic malignancies are currently registered. Therefore, our knowledge of recent advances in hemato-oncology is highly relevant for successful therapy of these malignancies. In this review we provide information on the subtypes, symptoms, diagnosis and treatment of acute myeloid leukemia (AML) – one of the most aggressive blood cancer.
Cross-Country Trends in Affective Polarization

Abstract We measure trends in affective polarization in twelve OECD countries over the past four decades. According to our baseline estimates, the United States experienced the largest increase in polarization over this period. Five countries experienced a smaller increase in polarization. Six countries experienced a decrease in polarization. We relate trends in polarization to trends in potential explanatory factors.
Mechanisms and spatial patterns of bark beetle-associated mortality following variable density thinning treatments in a sierra mixed-conifer forest

Over recent decades, substantial increases in tree mortality and unprecedented bark beetle outbreaks has occurred during severe drought conditions. With compounding disturbances such as these expected to increase in frequency and intensity with climate change, managers must develop creative ways to promote resistance in forests. While thinning is often used to increase growing space and improve tree health, treatments that enhance spatial heterogeneity may provide an alternative approach to promoting resistance to disturbances. Variable density thinning is a management method that can also reduce competition, but residual trees are intended to mimic the spatial heterogeneity that was present in forests historically. However there exists little research evaluating how forests treated with variable density thinning respond to drought and bark beetles. This study quantifies the relationship between drought resistance and bark beetleassociated mortality. We also evaluate whether reductions in competition affect the capacity of trees that survived bark beetle-associated mortality to withstand prolonged drought conditions. We conducted a paired-tree experiment to compare drought resistance characteristics between trees that died from bark beetle-associated mortality and trees that survived. We randomly chose 40 live and recently dead sugar pine (Pinus
Removal of Nitrate, Ammonium, and Phosphate from Water Using Conocarpus and Paulownia Plant Biochar

In this research, the biochar ability of Conocarpus and Paulownia plant as adsorbents to remove Nitrate, Ammonium, and phosphate from the water were investigated. For this purpose, the effect of contact time, initial concentration, and pH of solution on the removal of Nitrate, Ammonium, and phosphate by the biochar of Conocarpus and Paulownia plants have studied. The Conocarpus and Paulownia plants have been modified by ferrous chloride for nitrate removal. Conocarpus and Paulownia have been modified by potassium hydroxide for ammonia removal. Also, Conocarpus have been modified by ferrous chloride and Paulownia has modified by Potassium hydroxide for phosphate removal. The studied adsorbent properties with FT-IR and SEM, which their physical properties are: density, organic material percent, ash percent, mass moisture, and special surfaces have been determined by the methylene blue method. The Pseudo-First-order order, Pseudo-Second-order, Elovich, Intraparticle diffusion, and power have been used for describing the kinetic data. In addition, the Langmuir model, Freundlich, Temkin, Halsy, and Langmuir-Freundlich have used for describing the isotherm adsorption data. The results of this study showed that the Nitrate, Ammonium, and phosphate adsorption level has increased bypassing the time and after 60 and 120 min, they have reached their maximum level respectively. The maximum Ammonium adsorption level in modified biochar of Conocarpus was in pH=6, and in Palonia biochar was in pH=2 and the maximum nitrate adsorption was in pH=2. In addition, the maximum phosphate adsorption was in pH=8. By increasing the initial concentration of phosphate and nitrate, the removal efficiency has increased. The maximum phosphate removal efficiency in the concentration of 14mg/L in modified paulownia and Conocarpus biochar was 100%. In addition, the concentration of 50mg/L nitrate in modified Paulownia biochar was 98.37%. The maximum Ammonium removal efficiency in the concentration of 5 mg/ L by modified Conocarpus biochar was 82%.
Design and operation of closed-loop triple-deck buck-boost converter with high gain soft switching

This paper presents the design and operation of three-stage buck-boost converter with high gain soft switching using closed loop proportional integral (PI) controller. The proposed converter is designed by arranging three identical buck-boost converters working in parallel. The converter units are connected to each other by an inductor as a bridge. This inductor plays a vital role in soft switching operation of converter by maintaining the voltage applied to switches at zero voltage at switching intervals, i.e., the zero-voltage switching (ZVS). The closed-loop system is designed by PI controller, and it maintains the output constant irrespective of changes in input, and the system becomes stable. The proposed converter is efficient in reducing switching losses, leading to improved converter efficiency. Due to parallel operation of three identical converters, the output voltage and input current contain fewer ripples than those of a single converter with same specifications. Proposed converter is more economical and reliable with simpler structure as it utilizes only two inductors as extra elements. The design and analysis of proposed circuit has been carried out in MATLAB Simulink by operating the circuit in various modes.
DIAGNOSTIC VALUE OF MICROSCOPIC EXAM AND UREASE TEST IN HELICOBACTER SPECIES INFECTIONS

Authors have followed-up the presence of Helicobacter pylori and Helicobacter heilmannii in 4818 gastric mucosa biopsies in children with upper dispeptic manifestations, by microscopic examination of Gram fuchsin stained smear and Giemsa stained histological sections and by pre-formed urease test. Prevalence of these infections was 45.4% and 0.8% respectively, being assessed the endoscopic and histopathological aspects of studied cases. Classification on age groups of these ethiologies showed the predominance of positive cases after 10 years age. None of the investigated cases showed simultaneous presence of the two species.
Absence of nebulin in cardiac muscles of the chicken embryo

Nebulin, a high molecular weight (~700 kDa) protein of vertebrate skeletal muscle, was not detected in embryonic and adult cardiac muscles of the chicken by SDS-gel electrophoresis. No peptides reactive with anti-nebulin antiserum were found by immunoblot tests. Nebulin was detected in chicken embryonic skeletal muscles after 17 days of incubation. On the other hand, connectin, another giant protein, was present in both cardiac and skeletal muscles of the chicken embryos after 15 days of incubation. Nebulin is the second largest protein (M. W., ~700 kDa) in vertebrate skeletal muscles (8), and is localized in the I band about 120 nm apart from the Z lines of chicken skeletal muscle myofrbrils (6). It has been reported that nebulin is more or less degraded in Duchenne dystrophic muscles (5, 9), although its physiological role remains unknown. We have shown that nebulin band is not detected in frog, chicken, and rabbit cardiac muscles by SDS-gel electrophoresis (2). Locker and Wild (3) also reported the absence of the nebulin by SDS-gel electrophoresis of samples from chicken, rabbit and sheep heart muscles. It is still possible that nebulin with a molecular mass other than 700 kDa exists in cardiac muscles. Another possibility is that 700 kDa nebulin is expressed in early embryonic muscles but its expression ceases in differentiated muscles (cf 4). The present investigation clearly excludes the above-mentioned possibilities using immunoblot techniques. Chicken cardiacmuscleswere gentlyhomogenized with two volumes of an SDS-solution (10% sodium dodecyl sulfate, 40 mM dithiothreitol, 10 mM EDTA and 0.1 M Tris buffer, pH 8.0) and heated for 2-3 min at 100°C. The suspension was clarified by centrifugation for A B :tr . ; \ ; i _. ,. ,,',,-,1 -_:. _-'. 1; ,. -t , ,1, -3 if 2 5' 3 ="‘*T“"“+-_;-. -. ;,. -. 15>? -a\‘;-:41;'. '3:. :s¥;'l\:>. >‘<". =:=>“;‘ 2':1-;';'}'. ='z‘=5§;3? :. 'L? ;3-i i I-Y? -E"-. ": '1" _-; _ '1 t -. 1 u "M M _:_. ;_. ; 11. ;-ll _: __ . _ . _. --an ' :. :-;'. §5=_r_='_'_'-_-;; __'\ . ;. -. -_-_3i ---. ----=1;-. -=-5-=i=-. ‘ . _,3‘ -_ 5, i
Gene Expression Profiling Predictive of Tipifarnib (ZARNESTRA ® , R115777) Response in Patients with Newly Diagnosed Acute Myeloid Leukemia.

The farnesyltransferase inhibitor (FTI), tipifarnib (ZARNESTRA®, R115777), has demonstrated clinical response in patients with hematological disease. While the inhibition of protein farnesylation is the primary mechanism of action (MOA), the level of farnesyl inhibition is not a reliable pharmacodynamic marker of response, nor is it clear what genetic markers can be employed to predict response. This prospectively designed study was conducted to identify potential genetic markers and expression signatures that may be surrogate predictors of response for tipifarnib in patients with acute myeloid leukemia (AML). Bone marrow samples were collected and gene expression profiles analyzed from a single arm phase 2 clinical study of tipifarnib in poor-risk patients with newly diagnosed AML (Lancet, et al. Blood. 2004;104:249a). In total, 79 samples were obtained before (n = 25), during (n = 30), and after (n = 24) tipifarnib treatment. Bone marrow samples were analyzed using the Affymetrix U133A GeneChip® array. Global gene expression signatures revealed that tipifarnib treatment resulted in gene expression changes that were maintained for up to 120 days following treatment termination. Pretreatment vs posttreatment samples identified approximately 500 genes that had significant changes (False Discovery Rate [FDR] <0.005) in gene expression following farnesyltransferase inhibition, including several genes associated with farnesylation (eg, K-ras, FNTA). Many of the modulated genes were identified as those significantly involved in protein biosynthesis, DNA replication, intracellular signaling, and cell cycle pathways, thus, reflective of inhibition of cellular proliferation. A subset of 27 genes (including genes associated with signal transduction and cell cycle) was also identified as being differentially modulated between responders and nonresponders ( P <0.01). Gene expression signatures previously identified from a phase 2 clinical trial in relapsed and refractory AML were also tested in pretreatment samples to examine their ability to predict response (Raponi, et al. Blood. 2004;104:246a). A combination of 6 genes was found to have significant predictive accuracy in this independent set of samples ( P = 0.05). The genes identified from these studies might be used as surrogate biomarkers of tipifarnib activity.