Miracle-dz/UniFAR-FTUs huggingface dataset:
Web Communication Protocols for Coordinating the Modules of AnHitz, a Basque-Speaking Virtual 3D Expert on Science and Technology

AnHitz is a prototype of a virtual Basque-speaking 3 D expert that can answer questions or perform cross -lingual searches on science and technology, and show the search results in Basqu e by means of machine translation. It has been name d aft r the 3-year strategic research project on language, speech and visual tec hnologies for Basque carried out by several organiza tions, and built as a demonstrator of the technologies developed. Because the six modules comprising AnHitz have been impleme nted by different organizations using different operating systems, pr ogramming languages or libraries, it was impossible to build the demonstrator in a single executable or machine. As a result, the prot otype has been constructed using separate programs in various machines that interact using network communication and web services protoc ols. Despite the employed approach having some draw backs –mainly higher time delays when audio rendering is done via the we b–, the outcome is indeed satisfactory, as it has a llowed us to build a fully functional demonstrator that has showed good perfor mance and acceptance in an evaluation made with 50 users, and has made a great impact on the Basque media.
Disparities in Temporal and Geographic Patterns of Myocardial Infarction Hospitalization Risks in Florida

Knowledge of geographical disparities in myocardial infarction (MI) is critical for guiding health planning and resource allocation. The objectives of this study were to identify geographic disparities in MI hospitalization risks in Florida and assess temporal changes in these disparities between 2005 and 2014. This study used retrospective data on MI hospitalizations that occurred among Florida residents between 2005 and 2014. We identified spatial clusters of hospitalization risks using Kulldorff’s circular and Tango’s flexible spatial scan statistics. Counties with persistently high or low MI hospitalization risks were identified. There was a 20% decline in hospitalization risks during the study period. However, we found persistent clustering of high risks in the Big Bend region, South Central and southeast Florida, and persistent clustering of low risks primarily in the South. Risks decreased by 7%–21% in high-risk clusters and by 9%–28% in low-risk clusters. The risk decreased in the high-risk cluster in the southeast but increased in the Big Bend area during the last four years of the study. Overall, risks in low-risk clusters were ahead those for high-risk clusters by at least 10 years. Despite MI risk declining over the study period, disparities in MI risks persist. Eliminating/reducing those disparities will require prioritizing high-risk clusters for interventions.
Phytic Acid Intercalated Graphene Oxide for Anticorrosive Reinforcement of Waterborne Epoxy Resin Coating

Epoxy resin coatings were prepared with phytic acid-doped graphene oxide (PA-GO) to modify epoxy resins (EP). The aim was to improve the dispersion of GO in waterborne epoxy resin, and thus to improve the corrosion resistance of steel structures. The Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) results showed that PA-GO was successfully prepared and has a better dispersion in epoxy resin. This is mainly due to the PA insert, which increased the layer spacing of the GO. The results obtained under the controlled corrosive environment showed that the specimen coated with EP containing 1.0 wt. % PA-GO had better corrosion resistance than other samples. This resistance was also two orders of magnitude higher than pure epoxy coating. The main reason for this is that the dispersion of GO in waterborne epoxy resin had been improved.
Sex Differences in Liver, Adipose Tissue, and Muscle Transcriptional Response to Fasting and Refeeding in Mice

Fasting is often used for obesity correction but the “refeeding syndrome” limits its efficiency, and molecular mechanisms underlying metabolic response to different food availability are under investigation. Sex was shown to affect hormonal and metabolic reactions to fasting/refeeding. The aim of this study was to evaluate hormonal and transcriptional responses to fasting and refeeding in male and female C57Bl/6J mice. Sex asymmetry was observed both at the hormonal and transcriptional levels. Fasting (24 h) induced increase in hepatic Fgf21 gene expression, which was associated with elevation of plasma FGF21 and adiponectin levels, and the upregulation of expression of hepatic (Pparα, Cpt1α) and muscle (Cpt1β, Ucp3) genes involved in fatty acid oxidation. These changes were more pronounced in females. Refeeding (6 h) evoked hyperinsulinemia and increased hepatic expression of gene related to lipogenesis (Fasn) only in males and hyperleptinemia and increase in Fgf21 gene expression in muscles and adipose tissues only in females. The results suggest that in mice, one of the molecular mechanisms underlying sex asymmetry in hepatic Pparα, Cpt1α, muscle Cpt1β, and Ucp3 expression during fasting is hepatic Fgf21 expression, and the reason for sex asymmetry in hepatic Fasn expression during refeeding is male-specific hyperinsulinemia.
A histomorphometric study on treated and untreated ceramic filled PEEK implants versus titanium implants: Preclinical in vivo study

Abstract Objectives To investigate the osseo‐integrative behavior of untreated (UCFP) and sandblasted ceramic filled PEEK (SCFP) implants in comparison with titanium implants through measurement of bone implant contact (BIC) and bone density (BD). Materials and methods Nine implants from each type were inserted into 9 dogs in which every experimental dog received the three different implants in the lower border of the mandible. The animals were euthanized after 3 months and extracting bone blocks containing implants followed by blocks preparation for histological examinations. Results BIC and BD were significantly higher in titanium and SCFP compared with UCFP group (p = .007) and (p = .012), respectively. Aluminum blasting increased the bone ingrowth and bone implant contact when compared to machined surfaces of untreated PEEK implants. Conclusion In conclusion, sandblasting with 110 µm aluminum oxide particles can be proposed as a suitable surface treatment that enhances hydrophilicity of CFP. Further in vivo animal studies are still needed to confirm the findings of this study.
Soundscape-Sensing in Social Networks

In this paper we present a status report of the design and development stages of an online social network system based on Soundscapes. Additionally, a detailed description of the auditory scene analysis module of the system is made. The term Soundscape is used to describe the relation and interaction between the acoustic environment of a place and its inhabitants, namely on how these perceive and judge the sound. From this premise we developed a mobile application that senses and shares information regarding the Soundscapes of the places inhabited by each user during his/her daily life. Thus, each user acts as a terminal of a sensor network linked through the use of sound. The goal of this research is to assess the use of Soundscapes in social network interactions and consequently promote sound awareness among people.
Estimation of Covariance Matrix Distances in the High Dimension Low Sample Size Regime

A broad family of distances between two covariance matrices <tex>$C_{1}, C_{2}\in \mathbb{R}^{p\times p}$</tex>, among which the Frobenhius, Fisher, Battacharrya distances as well as the Kullback-Leibler, Rényi and Wasserstein divergence for centered Gaussian distributions can be expressed as functionals <tex>$\frac{1}{p}\sum_{i=1}^{p}f(\lambda_{i}(C_{1}^{-1}C_{2}))$</tex> or <tex>$\frac{1}{p}\sum_{i=1}^{p}f(\lambda_{i}(C_{1}C_{2}))$</tex> of the eigenvalue distribution of <tex>$C_{1}^{-1}C_{2}$</tex> or <tex>$C_{1}C_{2}$</tex>. Consistent estimates of such distances based on few <tex>$(n_{1},\ n_{2})$</tex> samples <tex>$x_{i}\in \mathbb{R}^{p}$</tex> having covariance <tex>$C_{1}, C_{2}$</tex> have been recently proposed using random matrix tools in the regime where <tex>$n_{1}, n_{2}\sim p$</tex>. These estimates however demand that <tex>$n_{1}, n_{2} > p$</tex> for most functions <tex>$f$</tex>. The article proposes to alleviate this limitation using a polynomial approximation approach. The proposed method is supported by simulations in practical applications.
The study of left ventricular relaxation and filling abnormalities in acute coronary syndrome by doppler echocardiography

Objectives: To study the left ventricular relaxation and filling abnormalities by doppler echocardiography and prognosis of acute coronary syndrome. Methods: Fifty patients of acute coronary syndrome were included in the study. The left ventricular diastolic dysfunction was studied using doppler transmitral velocities within the apical 4- chambers view (1st study-on the day of admission and 2nd study- after one week). The various parameters studied were peak E (peak rapid filling velocity), peak A (atrial contraction wave), E/A ratio, E-DT (E- deceleration time), IVRT (isovolumetric relaxation time), S-wave (systolic forward flow wave), D-wave (diastolic forward flow wave) and AR-wave (atrial reversal wave). Results: Of 50 patients studied 3 had normal, 36 patients had impaired relaxation, 5 patients had pseudo-normalization, 4 patients reversible and 2 patients irreversible restrictive filling on the day of admission (1st study). In the 2nd study (after one week) 16 were normal, 20 patients had impaired relaxation, 5 patients had pseudo-normalization, 6 patients had reversible and 2 patients had irreversible restrictive filling. Conclusion: Doppler echocardiographic assessment of left ventricular diastolic dysfunction in the setting of acute coronary syndrome helps in the management and provides independent noninvasive prognostic information.
Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers

Microparticulated drug delivery systems have been used as promising encapsulation systems for protecting drugs for in vitro and in vivo applications, enhancing its stability, providing an increased surface to volume ratio, reducing adverse effects, and hence an improvement in bioavailability. Among the studied microparticles, there is a rising interest in the research of alginate microparticles for pharmaceutical and biomedical fields confirming its potential to be used as an effective matrix for drug and cell delivery. Moreover, calcium alginate has been one of the most extensively forming microparticles in the presence of divalent cations providing prolonged drug release and suitable mucoadhesive properties. Regarding the above mentioned, in this research work, we intended to produce Ca-alginate micro-vehicles through electrospraying, presenting high encapsulation efficiency (EE%), reduced protein release across the time, reduced swelling effect, and high sphericity coefficient. To quickly achieve these characteristics and to perform an optimal combination among the percentage of alginate and CaCl2, design of Experiments was applied. The obtained model presented to be statistically significant (p-value < 0.05), with a coefficient of determination of 0.9207, 0.9197, 0.9499, and 0.9637 for each output (EE%, release, swelling, and sphericity, respectively). Moreover, the optimal point (4% of alginate and 6.6% of CaCl2) was successfully validated.
Outcomes of stereotactic radiosurgery for pilocytic astrocytoma: an international multiinstitutional study.

OBJECTIVE The current standard initial therapy for pilocytic astrocytoma is maximal safe resection. Radiation therapy is considered for residual, recurrent, or unresectable pilocytic astrocytomas. However, the optimal radiation strategy has not yet been established. Here, the authors describe the outcomes of stereotactic radiosurgery (SRS) for pilocytic astrocytoma in a large multiinstitutional cohort. METHODS An institutional review board-approved multiinstitutional database of patients treated with Gamma Knife radiosurgery (GKRS) between 1990 and 2016 was queried. Data were gathered from 9 participating International Radiosurgery Research Foundation (IRRF) centers. Patients with a histological diagnosis of pilocytic astrocytoma treated using a single session of GKRS and with at least 6 months of follow-up were included in the analysis. RESULTS A total of 141 patients were analyzed in the study. The median patient age was 14 years (range 2-84 years) at the time of GKRS. The median follow-up was 67.3 months. Thirty-nine percent of patients underwent SRS as the initial therapy, whereas 61% underwent SRS as salvage treatment. The median tumor volume was 3.45 cm3. The tumor location was the brainstem in 30% of cases, with a nonbrainstem location in the remainder. Five- and 10-year overall survival rates at the last follow-up were 95.7% and 92.5%, respectively. Five- and 10-year progression-free survival (PFS) rates were 74.0% and 69.7%, respectively. On univariate analysis, an age < 18 years, tumor volumes < 4.5 cm3, and no prior radiotherapy or chemotherapy were identified as positive prognostic factors for improved PFS. On multivariate analysis, only prior radiotherapy was significant for worse PFS. CONCLUSIONS This represents the largest study of single-session GKRS for pilocytic astrocytoma to date. Favorable long-term PFS and overall survival were observed with GKRS. Further prospective studies should be performed to evaluate appropriate radiosurgery dosing, timing, and sequencing of treatment along with their impact on toxicity and the quality of life of patients with pilocytic astrocytoma.
Muscle cross‐sectional area and motor unit properties of the medial gastrocnemius and vastus lateralis in normal weight and overfat children

What is the central question of this study? Are differences in muscle size and motor unit properties between normal weight and overfat children muscle specific? What is the main finding and its importance? Muscle cross‐sectional area and motor unit action potential amplitudes and firing rates were similar between overfat and normal weight children for both the medial gastrocnemius and vastus lateralis muscles. There was no evidence that the chronic mechanical overload provided by the greater body mass resulted in significant hypertrophy of contractile tissue or motor units that would be used during lower‐to‐moderate intensity activities.
Ponatinib therapy in recurrent Philadelphia chromosome‐positive central nervous system leukemia with T315I mutation after Allo‐HSCT

Central nervous system leukemia (CNSL) relapse is relatively common among Philadelphia chromosome‐positive (Ph+) leukemia patients who undergo allogeneic hematopoietic stem cell transplantation (allo‐HSCT). The prognosis of patients is dismal for those with a BCR‐ABL T315I mutation, which is resistant to TKIs including second‐generation drugs. We assessed ponatinib for nine patients with recurrent Ph+ CNSL and a T315I mutation after allo‐HSCT, including five patients with Ph+ acute lymphoblastic leukemia and four with chronic myelogenous leukemia. Five patients experienced isolated CNSL relapse, and four experienced CNSL with hematologic relapse. All patients received ponatinib combined with intrathecal chemotherapy, and four patients with hematologic relapse received systemic chemotherapy and/or donor lymphocyte infusion. All patients achieved a deep molecular response and central nervous system remission (CNSR) at a median time of 1.5 (range: 0.7–3) months after ponatinib treatment. Two patients experienced a second CNSL relapse due to ponatinib reduction, but they achieved CNSR again after an increase to the standard dosage. Six patients developed graft versus host disease. By April 1, 2019, eight patients were alive, and one died of pneumonia. The median time of survival after the first CNSL relapse posttransplantation was 18 (range: 11.2–48.5) months. Our data from a small number of samples suggests that ponatinib is effective for recurrent Ph+ CNSL patients with a BCR‐ABL T315I mutation after allo‐HSCT and warrants broader clinical evaluation.
Optimization of high endoglucanase yields production from polypore fungus, Microporus xanthopus strain KA038 under solid-state fermentation using green tea waste

ABSTRACT Polypores are diverse macrofungi that have been extensively studied for their lignocellulolytic enzyme production capabilities. Currently, these enzymes are being used for many industrial purposes. However, the high cost associated with their production is the main barrier to their broader application. This work aimed to study the optimal medium and conditions for endoglucanase production using solid state fermentation. Seven polypore strains were used for endoglucanase activity screening. The fermentation experiments were carried out in 250 ml Erlenmeyer flasks with green tea waste as a substrate. Notably, Microporus xanthopus strain KA038 showed the best level of activity (38.62 IU/gds). Various parameters such as moisture content, nitrogen source, initial pH value, inoculum size and incubation time were considered to determine the optimal conditions for endoglucanase production. The optimal medium consisted of green tea leaves as a carbon source, beef extract as an organic nitrogen source, NH4H2PO4 as an inorganic nitrogen source, pH 7.0 and an incubation temperature at 30°C for 4 days resulted in a high enzyme yield with M. xanthopus strain KA038 (81.8 IU/gds). This article has an associated First Person interview with the first author of the paper. Summary: Our findings show that one polypore fungal species Microporus xanthopus strain, KA038, can produce high endoglucanase yields through optimizing production conditions.
Antibiotics Versus Natural Biomolecules: The Case of In Vitro Induced Bacteriospermia by Enterococcus Faecalis in Rabbit Semen

Male subfertility is a global issue in human reproduction as well as in animal reproduction. Bacterial infection and semen contamination are still widely overlooked. As the collection of ejaculates is not a sterile process, it is necessary to add antimicrobial agents to avoid a possible depreciation of semen samples. As traditionally used antibiotics have been questioned because of an ever-increasing bacterial resistance, natural bioactive molecules could offer an alternative because of their antibacterial and antioxidant properties. As such, we decided to compare the effects of selected natural biomolecules (resveratrol-RES, quercetin-QUE and curcumin-CUR) with routinely used antibiotics in animal biotechnologies (penicillin-PEN, gentamicin-GEN and kanamycin-KAN) on the rabbit sperm vitality in the presence of Enterococcus faecalis. Changes in the sperm structural integrity and functional activity were monitored at 0, 2, 4 and 6 h. Computer-assisted sperm analysis (CASA) was used for the assessment of spermatozoa motility. Production of reactive oxygen species (ROS) was evaluated using chemiluminiscence, while the mitochondrial membrane potential (ΔΨm) was examined using the JC-1 dye. Finally, the sperm chromatin dispersion (SCD) test was used to assess DNA fragmentation, and changes to the membrane integrity were evaluated with the help of annexin V/propidium iodide. The motility assessment revealed a significant sperm motility preservation following treatment with GEN (p < 0.001), followed by PEN and CUR (p < 0.01). QUE was the most capable substance to scavenge excessive ROS (p < 0.001) and to maintain ΔΨm (p < 0.01). The SCD assay revealed that the presence of bacteria and antibiotics significantly (p < 0.05) increased the DNA fragmentation. On the other hand, all bioactive compounds readily preserved the DNA integrity (p < 0.05). In contrast to the antibiotics, the natural biomolecules significantly maintained the sperm membrane integrity (p < 0.05). The microbiological analysis showed that GEN (p < 0.001), KAN (p < 0.001), PEN (p < 0.01) and CUR (p < 0.01) exhibited the strongest antibacterial activity against E. faecalis. In conclusion, all selected biomolecules provided protection to rabbit spermatozoa against deleterious changes to their structure and function as a result of Enterococcus faecalis contamination. Therefore, administration of RES, QUE and/or CUR to rabbit semen extenders in combination with a carefully selected antibacterial substance may be desirable.
Information section

March 30-ApriI4, 1981, Rostock: Diskrete Mathematik und Anwendungen in der mathematischen Kybernetik (Professor G. Burosch, Wilhelm-Pieck-Universitiit Rostock, Sektion Mathematik, 2500 Rostock, Universitiitsplatz 1, East Germany) May 28-30,1981, Berlin: Colloquium in honour of Professor H. Lenz (Professor M. Aigner, Freie Universitiit Berlin, II. Mathematisches Institut, Konigen-LuiseStrasse 24/26, 1000 Berlin 33, West Germany) June 1-13, 1981, Singapore: The International Mathematical Conference includes a session on Combinatorics (The Organizing Secretary, International Mathematical Conference 1981, Department of Mathematics, National University of Singapore, Bukit Timah Road, Singapore 1025, Republic of Singapore) June 7-12,1981, Roma: Convegno Internazionale: Geometrie, Combinatorie e loro Applicazioni (to commemorate Beniamino Segre) (Professor P. V. Ceccherini, Istituto Matematico "G. Castelnuovo", CittMI Universitaria, 00185, Roma, Italy) June 10-12, 1981, Troy, New York: Applications of Discrete Mathematics (Mr H. B. Hair, SIAM, 117 South 17th Street, Philadelphia, Pennsylvania 19103, U.S.A.) June 15-20, 1981, Marseille-Luminy: Colloque International sur la Theorie des Graphes et la Comb ina to ire (Professeur F. Sterboul, Colloque Combinatoire 1981, C.M.S., 54 Boulevard Raspail, 75006 Paris, France) July 6-11, 1981, Eger: 6th Hungarian Colloquium on Combinatorics, Finite and Infinite Sets (Professor E. Gyori, Combinatorics, J. Bolyai Mathematical Society, H-1368 Budapest, Pf. 240, Hungary) 1m Mathematischen Forschungsinstitut Oberfolwach (Tagungsprogramm: Mathematisches Forschungsinstitut Oberfolwach, 24 Albertstrasse, D-7800 Freiburg, West Germany) July 12-18, 1981: Discrete Geometries (L. F. Toth) July 19-25, 1981: Endliche Gruppen und Permutationsgruppen (C. Hering, B. Huppert) July 20-24, 1981, Swansea: 8th British Combinatorial Conference (Professor H. N. V. TemperIey, University College, Swansea, South Wales, U.K.) August 24-28,1981, Stirling: Combinatorial Optimization Conference CO 81 (Professor L. B. Wilson (CO 81), Department of Computing Science, University of Stirling, Stirling FK9 4LA, U.K.) August 28-September 12, 1981, Banff: Symposium on Ordered Sets (Professor I. Rival, Department of Mathematics and Statistics, The University of Calgary, Calgary, Alberta T2N 1N4, Canada) June 14-July 2, 1982, Waterloo: Conference on Combinatorics (Combinatorics Conference, Department of Combinatorics and Optimization, University of Waterloo, Ontario, Canada, N2L 3G1)
Psychiatric Emergencies in Children and Adolescents: An Emergency Department Audit

Objective: To describe a cohort of children presenting to a paediatric emergency department with mental health problems. Methods: An Emergency Department (ED) computerized record system and hospital records were used to obtain data on children who presented to a paediatric ED with mental health problems. Results: There were 291 presentations of 231 children in a 10-month period, about one per day. They were a small (0.8%) but complicated part of the ED workload. Most were first presentations and came voluntarily to ED. There were a wide variety of presenting symptoms including self-harm, suicide attempts, behavioural disorders and medical disorders with associated psychological problems. Acute psychosis was rare. Conclusions: Many children with mental health problems were seen for the first time in ED. With the growing awareness of mental health problems in this age group, it is likely that such presentations will increase. Paediatric and psychiatry services have an opportunity to work together to provide early intervention services for what is potentially a very accessible population.