Miracle-dz/UniFAR-FTUs huggingface dataset:
Intralesional botulinum toxin type A equally effective and better tolerated than intralesional steroid in the treatment of keloids: a randomized controlled trial

Intralesional (IL) corticosteroid therapy is a treatment for keloids. IL botulinum toxin type A (BTA) has been postulated in such an indication with controversial reports. To compare efficacy and safety of IL BTA to the IL corticosteroid therapy in treatment of keloids. Twenty‐four patients with keloids were randomly divided into two equal groups: receiving IL steroid repeated every 4 weeks for six sessions (group A) and IL BTA 5 IU/cm3 repeated every 8 weeks for three sessions (group B). Objective parameters (hardness, elevation, and redness), subjective complaints (itching, pain, and tenderness), patient satisfaction, and side effects were evaluated. There was a significant decrease in the volume of the lesions after treatment (P < 0.01), with a volume reduction of 82.7% and 79.2%, respectively, in both groups. A significant softening of lesions vs. baseline was observed (P < 0.01), with statistically significant improvement in softening in group A (P < 0.01). There was a significant decrease in height of lesions and in redness score compared with baseline (P < 0.01) with no significant difference in between both groups. All patients mentioned a significant reduction of their subjective complaints (P < 0.01) that were more significant in group B. Skin atrophy and telangiectasia were evident in three patients of group A. The efficacy and safety of the IL BTA were clearly evident in the current work from the rapid significant amelioration of the subjective complaints and the comparable significant improvement of the objective parameters as well as the volume of the keloids in comparison with the IL corticosteroids.
Comparison of dorzolamide/timolol and latanoprost/timolol fixed combinations on diurnal intraocular pressure control in primary open-angle glaucoma.

PURPOSE To compare the efficacy and safety of dorzolamide hydrochloride 2%/timolol maleate 0.5% fixed combination (DTFC) with latanoprost 0.005%/timolol maleate 0.5% fixed combination (LTFC) on diurnal intraocular pressure (IOP) in patients with primary open-angle glaucoma. METHODS Thirty-three primary open-angle glaucoma patients with IOP of 22-32 mmHg measured at any time were included. Patients were randomized to either DTFC twice daily or latanoprost 0.005%/timolol maleate 0.5% fixed combination (LTFC) once a day in the evening. After a 6-week treatment period with each combination, IOP were measured every 4 h during 24 h (first diurnal curve) and after 6 weeks of washout period, the patients were switched to the other treatment for 6 weeks of the second diurnal curve. RESULTS The mean baseline IOP was 25.09±2.8 mmHg. After the treatment period, mean diurnal IOP was statistically lower with LTFC (16.3 mmHg) than with DTFC (17.3 mmHg), and the peak IOP value was 18.5 mmHg with LTFC and 19.9±2.6 mmHg with DTFC (P<0.05). No significant side effects were reported except stinging and bitter taste with the DTFC group. CONCLUSION Mean diurnal IOP and peak IOP were lower with LTFC than with DTFC in patients with primary open-angle glaucoma.
Monitoring regionaler Immobilienpreise 2014: Preisauftrieb auf breiter Front - aber geringe Gefahr von Blasen

In den vergangenen Jahren sind die Kaufpreise deutscher Immobilien deutlich gestiegen. Allerdings sind die Preissteigerungen sehr heterogen uber das Bundesgebiet verteilt. Indizien fur ubersteigerte Preiserwartungen sind nur fur vereinzelte Arbeitsmarktregionen zu finden und die Anzeichen fur eine landesweite Immobilienpreisblase daher sehr gering. Dennoch sollten die Preise in verschiedenen Arbeitsmarktregionen genauer beobachtet werden.
Diabetes mellitus and female sexuality: a review of 25 years’ research

Diabetes mellitus may cause debilitating somatic complications and a high psychosocial burden. Impaired sexual function (erectile dysfunction) is a well‐established complication in men. Does diabetes also have an effect on sexuality of women? Since the first publication in 1971, only 15 studies in this area have been published and their results are contradictory. The purpose of this article is to offer a review of these results. As a conclusion, a new hypothesis on the specific influence of diabetes on female sexuality and suggestions for further research are formulated. © 1998 John Wiley & Sons, Ltd.
Documentation of Auxotrophic Mutation in Blue-Green Bacteria: Characterization of a Tryptophan Auxotroph in Agmenellum quadruplicatum

A tryptophan-requiring auxotroph of Agmenellum quadruplicatum strain BG1, a species of blue-green bacteria, was isolated by means of a nitrosoguanidine-penicillin procedure. Its growth characteristics were determined, and the enzymological block was identified in the A activity of tryptophan synthetase. Starvation of the auxotroph for tryptophan resulted in the derepression of the synthesis of all five enzymes. The first four enzymes derepressed 2- to 3-fold, and tryptophan synthetase B derepressed 20-fold. In the parental prototroph, BG1, anthranilate synthetase was active in crude extracts with ammonia as the amino donor reactant, but not with glutamine.
Adenocarcinoma: Identification of Three Independent Regions Loss of Heterozygosity at Chromosome 16q in Prostate Updated Version Citing Articles E-mail Alerts Loss of Heterozygosity at Chromosome 16q in Prostate Adenocarcinoma: Identification of Three Independent Regions1

Loss of heterozygosity (LOH) on chromosome arm 16q is one of the most consistent genetic alterations in sporadic prostate cancer and may be involved in cancer development through inactivation of tumor suppressor genes. A candidate tumor suppressor gene on this chromosome arm, CDHJ at 16q22.1, is dysregulated in prostate cancer. However, no specific deletionmap has been constructedfrom prostatetumorsto determine whether CDHJ is the potential target gene for the observed LOH on 16q. To narrow down the region of 16q loss, we constructed a detailed deletion map that incorporates CDHJ. We examined the pattern of allelic imbal ance in prostate tissue from 22 patients with confined prostate tumors, 22 with local extracapsular extension, and 15 with metastatic forms, using 14 CA microsateffite repeats on 16q. Thirty-five of the 59 tumors tested showed LOH for at least one marker. We found evidence of 16q mono somy in 5 cases and partial allelic loss in 30. Our data provide evidence that three different target regions on 16q might be involved in the patho genesisof prostatecancer.Thefirstregionis telomericandliesat 16q24.3 between markers D16S520 and D16S413; the second, the most centro meric region in the 16q22.1 band, and limited by markers D16S347 and D16S318, is close to the CDHJ gene; the third, intermediate region, at 16q23.2, is bracketed by loci D16S518 and D16S507 The rate ofLOH at 16q24.3 was significantly higher in metastatic forms (80%; 12 of 15) than localized forms (32%; 7 of 22), pointing to a gene related to invasiveness in prostate cancer.
Acute lung injury is reduced by the α7nAChR agonist PNU‐282987 through changes in the macrophage profile

Nicotinic α‐7 acetylcholine receptor (nAChRα7) is a critical regulator of cholinergic anti‐inflammatory actions in several diseases, including acute respiratory distress syndrome(ARDS). Given the potential importance of α7nAChR as a therapeutic target, we evaluated whether PNU‐282987, an α7nAChR agonist, is effective in protecting the lung against inflammation. We performed intratracheal instillation of LPS to generate acute lung injury (ALI) in C57BL/6 mice. PNU‐282987 treatment, either before or after ALI induction, reduced neutrophil recruitment and IL‐ 1β, TNF‐α, IL‐6, keratinocyte chemoattractant (KC), and IL‐10 cytokine levels in the bronchoalveolar lavage fluid (P> 0.05). In addition, lung NF‐κB phosphorylation decreased, along with collagen fiber deposition and the number of matrix metalloproteinase‐9+ and −2+ cells, whereas the number of tissue inhibitor of metalloproteinase‐1+ cells increased (P < 0.05). PNU‐282987 treatment also reduced lung mRNA levels and the frequency of M1 macrophages, whereas cells expressing the M2‐related markers CD206 and IL‐10 increased, suggesting changes in the macrophage profile. Finally, PNU‐282987 improved lung function in LPS‐treated animals. The collective results suggest that PNU‐282987, anagonist of α7nAChR, reducesLPS‐induced experimental ALI, thus supporting the notion that drugs that act on α7nAChRs should be explored for ARDS treatment in humans. —Pinheiro, N. M. , Santana, F. P. R. , Almeida, R. R. , Guerreiro, M. , Martins, M.A., Caperuto, L.C. , Câmara, N.O. S. , Wensing, L.A. , Prado, V. F. , Tibério, I. F. L. C. , Prado, M.A.M., Prado, C. M. Acute lung injury is reduced by the α7nAChR agonist PNU‐282987 through changes in the macrophage profile. FASEB J. 31, 320–332 (2017) www.fasebj. org
Deep dermal burn injury results in scarless wound healing in the ovine fetus

Early to mid‐term fetuses heal cutaneous incisional wounds without scars; however, fetal response to burn injury has not been ascertained. We present a fetal model of thermal injury and subsequent analysis of fetal and lamb response to burn injury. A reproducible deep dermal burn injury was created in the fetus by application of water at 66 °C for 7 seconds, and at 82 °C for 10 seconds to the lamb. Macroscopically, the area of fetal scald was undetectable from day 7 post injury, while all lamb scalds were readily identified and eventually healed with scarring. Using a five‐point histopathology scoring system for alteration in tissue morphology, differences were detected between control and scalded skin at all stages in lamb postburn, but no difference was detected in the fetal model after day 7. There were also large differences in content of α‐smooth muscle actin and transforming growth factor‐β1 between control and scalded lamb and these differences were statistically significant at day 14 (P < 0.01). This novel model of fetal and lamb response to deep dermal injury indicates that the fetus heals a deep burn injury in a scarless fashion. Further elucidation of this specific fetal process of burn injury repair may lead to improved outcome for patients with burn injury.
Spectroscopic Determination of the OH− Solvation Shell in the OH−·(H2O)n Clusters

There has been long-standing uncertainty about the number of water molecules in the primary coordination environment of the OH− and F− ions in aqueous chemistry. We report the vibrational spectra of the OH−·(H2O)n and F−·(H2O)n clusters and interpret the pattern of OH stretching fundamentals with ab initio calculations. The spectra of the cold complexes are obtained by first attaching weakly bound argon atoms to the clusters and then monitoring the photoinduced evaporation of these atoms when an infrared laser is tuned to a vibrational resonance. The small clusters (n ≤ 3) display an isolated, sharp feature near the free OH stretching vibration, the signature of open solvation morphologies where each water molecule binds independently to the ion. Pronounced changes in the spectra are observed at n = 4 in the hydroxide ion and at n = 5 in the fluoride ion. In both cases, new features appear in the region typically associated with interwater hydrogen bonding. This behavior establishes that the primary hydration shells occur at n = 3 and 4 in hydroxide and fluoride, respectively.
The effect of lactation number, stage, length, and milking frequency on milk yield in Korean Holstein dairy cows using automatic milking system

Objective The aim of the current study was to describe the relationship between milk yield and lactation number, stage, length and milking frequency in Korean Holstein dairy cows using an automatic milking system (AMS). Methods The original data set consisted of observations from April to October 2016 of 780 Holstein cows, with a total of 10,751 milkings. Each time a cow was milked by an AMS during the 24 h, the AMS management system recorded identification numbers of the AMS unit, the cow being milking, date and time of the milking, and milk yield (kg) as measured by the milk meters installed on each AMS unit, date and time of the lactation, lactation stage, milking frequency (NoM). Lactation stage is defined as the number of days milking per cows per lactation. Milk yield was calculated per udder quarter in the AMS and was added to 1 record per cow and trait for each milking. Milking frequency was measured the number of milkings per cow per 24 hour. Results From the study results, a significant relationship was found between the milk yield and lactation number (p<0.001), with the maximum milk yield occurring in the third lactation cows. We recorded the highest milk yield, in a greater lactation length period of early stage (55 to 90 days) at a 4× milking frequency/d, and the lowest milk yield was observed in the later stage (>201 days) of cows. Also, milking frequency had a significant influence on milk yield (p<0.001) in Korean Holstein cows using AMS. Conclusion Detailed knowledge of these factors such as lactation number, stage, length, and milking frequency associated with increasing milk yield using AMS will help guide future recommendations to producers for maximizing milk yield in Korean Dairy industries.
Role of chelatable iron versus myoglobin in oxidative stress after crush trauma.

Sebastian Rehberg,* Christoph Thiemermann, and Marc O. Maybauer* *Department of Anesthesiology, The University of Texas Medical Branch at Galveston, Texas; Center for Translational Medicine & Therapeutics, the William Harvey Research Institute, St Bartholomew’s, and the Royal London School of Medicine and Dentistry, London, UK; and Department of Anaesthesiology and Intensive Care, Philipps University of Marburg, Germany
A Classification System to Meet Today's Needs

Patient classification systems hold the promise of providing nursing services with objective and scientific means to identify acuity levels and project staffing requirements. Nursing administrators have an obligation to base nurse staffing on objective documentation. To ensure the cooperation of nursing staff, they must make the classification system meaningful to staff and patient care goals. A classification system based on accurate and objective assessment of patient acuity levels will enable administrators to use their most valuable resource--their nursing staff--efficiently and effectively.
CEREBRAL ASYMMETRIES IN HUMANS ARE DUE TO THE DIFFERENTIATION OF TWO INCOMPATIBLE PROCESSES: HOLISTIC AND ANALYTIC

Clinical and experimental evidence suggests that the left hemisphere of the brain is specialized for speech activity and the right hemisphere is specialized for many nonlinguistic functions. Jackson1 related the hemispheric linguistic differences t o differences in cognitive activity, suggesting that the left hemisphere is specialized for analytical organization, while the right hemisphere is adapted for “direct associations” among stimuli and responses. Modern researchers have substantially generalized this differentiation to encompass a wide range of behaviors in normal subjects. Experimental2 and clinical3 investigators of hemispheric asymmetry generally agree on the fundamental nature of the processing differences between the two sides of the brain: the left hemisphere is specialized for propositional, analytic, and serial processing of incoming information, while the right hemisphere is more adapted for the perception of appositional, holistic, and synthetic relations. This asymmetry raises the question of whether there are essential differences in the way in which the two hemispheres organize behavior and process information. Several theories attribute hemispheric differences to a structural differentiation of some kind. Asymmetries might be due to differences intrinsic to each hemisphere: e. g. , in the neurospatial organization of functions4 or the existence of modality-specific differences in capacity,S or to some fundamental differences in the way the elementary neurological interactions occur. The structural difference might exist because of forces extrinsic to the brain, e. g. , a muscular predisposition for handedness, asymmetries in sensory organs, or socially trained asymmetries in such observable traits as handedness and eyedness. Each of these views supposes that there is some physical or social structure that specifically and directly causes functional asymmetry to occur; that is, these proposals are all extremely strong in that they make concrete claims about the nature of the phenomenon. Yet the apparent precision of each claim is of little use t o us, since we d o not know the relevant facts that would critically prove or disprove any of them. I shall argue that unless we have evidence conclusively proving any of the more specific claims, we should view cerebral dominance as the result of certain general properties of the mind and of the relationship between the structures of the mind and the anatomy of the brain. The basic view underlying this proposal is that the mind is composed of a number of partially independent faculties, each of which has certain
Associations of the Expanded Disability Status Scale with anxiety and depression in multiple sclerosis outpatients

Objectives – We evaluated cross‐sectionally the associations of depression and anxiety with age, sex, duration of illness, educational level, degree of disability and treatment with interferon‐β in outpatients with relapsing–remitting multiple sclerosis (RRMS) during a clinically stable phase of their illness.
Effect of electronic health records in ambulatory care: retrospective, serial, cross sectional study

Abstract Objective To evaluate the effect of implementing comprehensive, integrated electronic health record systems on use and quality of ambulatory care Design Retrospective, serial, cross sectional study. Setting Colorado and Northwest regions of Kaiser Permanente, a US integrated healthcare delivery system. Population 367 795 members in the Colorado region and 449 728 members in the Northwest region. Intervention Implementation of electronic health record systems. Main outcome measures Total number of office visits and use of primary care, specialty care, clinical laboratory, radiology services, and telephone contact. Health Plan Employer Data and Information Set to assess quality. Results Two years after electronic health records were fully implemented, age adjusted rates of office visits fell by 9% in both regions. Age adjusted primary care visits decreased by 11% in both regions and specialty care visits decreased by 5% in Colorado and 6% in the Northwest. All these decreases were significant (P < 0.0001). The percentage of members making ≥ 3 visits a year decreased by 10% in Colorado and 11% in the Northwest, and the percentage of members with ≤ 2 visits a year increased. In the Northwest, scheduled telephone contact increased from a baseline of 1.26 per member per year to 2.09 after two years. Use of clinical laboratory and radiology services did not change conclusively. Intermediate measures of quality of health care remained unchanged or improved slightly. Conclusions Readily available, comprehensive, integrated clinical information reduced use of ambulatory care while maintaining quality and allowed doctors to replace some office visits with telephone contacts. Shifting patterns of use suggest reduced numbers of ambulatory care visits that are inappropriate or marginally productive.
Modeling and Planning on Urban Logistics Park Location Selection Based on the Artificial Neural Network

Nowadays China has been soaked in the craze of planning and construct u rban l ogistics p ark, and almost all developed countries all regard the urban logistics park’s construction as a major motivation to the national economic. It is vital that the scientific planning of urban logistics park will ensure China’s rapid development. However, too many inappropriate or unscientific planning and construction under the guidance of Government have brought giant economic loss to China. How to plan and design the urban logistics park scientifically, It is a hot topic of research being widely discussed not only by Government s but also enterprisers and scholars home and abroad. This paper begins with exploratory research for modeling and planning on the urban logistics park location selection based on the BP Artificial Neural Network (BP ANN). This paper divides into 3 sections: the first to mainly introduce the history of urban logistics park development and the significance of modelling and planning urban logistics park ,the second to analyze basic principle of the BP ANN, the third to simulate and plan the location selection of urban logistics park based on the BP ANN model. The urban logistics park’s location selection planning is a complicated and dynamical system engineering with a lot of black box problems, which can’t be resloved by System Dynamics, Expert System and traditional mathematical methods (e.g. Operations Research, Statistics), and BP ANN model has seldom been applied to plan urban logistics park in China. So, the research in this paper is an innovation.
An approach to identifying osteopenic women at increased short-term risk of fracture.

BACKGROUND Identification and management of women to reduce fractures is often limited to T scores less than -2.5, although many fractures occur with higher T scores. We developed a classification algorithm that identifies women with osteopenia (T scores of -2.5 to -1.0) who are at increased risk of fracture within 12 months of peripheral bone density testing. METHODS A total of 57 421 postmenopausal white women with baseline peripheral T scores of -2.5 to -1.0 and 1-year information on new fractures were included. Thirty-two risk factors for fracture were entered into a classification and regression tree analysis to build an algorithm that best predicted future fracture events. RESULTS A total of 1130 women had new fractures in 1 year. Previous fracture, T score at a peripheral site of -1.8 or less, self-rated poor health status, and poor mobility were identified as the most important determinants of short-term fracture. Fifty-five percent of the women were identified as being at increased fracture risk. Women with previous fracture, regardless of T score, had a risk of 4.1%, followed by 2.2% in women with T scores of -1.8 or less or with poor health status, and 1.9% for women with poor mobility. The algorithm correctly classified 74% of the women who experienced a fracture. CONCLUSIONS This classification tool accurately identified postmenopausal women with peripheral T scores of -2.5 to -1.0 who are at increased risk of fracture within 12 months. It can be used in clinical practice to guide assessment and treatment decisions.
A novel mechanosensitive cationic channel from the endothelium of rat aorta.

1. Single channel currents were recorded from the lumenal surface of endothelium of excised intact rat aorta using the patch clamp technique. 2. The majority of cell‐attached and inside‐out patches contained cationic channels with an equal permeability to Na+ and K+. Positive pressure applied through the pipette reversibly increased their open probability, whereas negative pressure reversibly decreased it. The dependence of the channel activity on pressure was sigmoidal in all tested patches. 3. The slope conductance of the channel for inward current was 33.9 +/‐ 2.1 pS in a nominally Ca(2+)‐free extracellular solution. With 1 mM CaCl2 in the extracellular solution, the channel conductance for inward current was reduced to 21.2 +/‐ 2.3 pS. In isotonic CaCl2 solution, the slope conductance of the channel was 5.9 +/‐ 1.3 pS. The ionic permeability ratio was PCa: PNa: PK = 3.5:1:1. 4. Gadolinium and lanthanum at a concentration of 10 microM did not affect the channels, but at higher concentrations (> or = 100 microM) reduced inward currents through the channels. 5. The mechanosensitive channel reported here is different in its gating mechanism and pharmacology from stretch‐activated channels described previously. This channel may be involved in mechanotransduction of haemodynamic stimuli in endothelium.