Miracle-dz/UniFAR-FTUs huggingface dataset:
‘Stood to rest’: reorientating necrogeographies for the 21st century

ABSTRACT Human bodies are typically buried underground, horizontally ‘in repose’. To the extent that this orientation has become the standard; it is a non-choice that is under-interrogated by scholars. In this paper, we discuss innovations which allow for the vertical orientation of the body within the earth and for the vertical stacking of remains above the earth in high-rise structures. Both of these boundary-pushing forms of disposition address imminent shortages in the land allocated for cemeteries in the context of intense urbanisation and a peaking death rate. They also promise to transform the necrogeography of contemporary cities and intimate relations between the living and the dead. This paper is a collaboration between the DeathTech Research Team and the Managing Director of Upright Burials, where the dead are ‘stood to rest’ in shaft graves. The pragmatic advantages of vertical burial are easily explicated, but in this paper, we focus on the cultural and symbolic dimensions of this largely unfamiliar spatial relation and the challenges of ‘reorienting’ the public towards this new form of disposition.
Chemotherapy induced peripheral neuropathy onset increases the early risk for depression and anxiety in breast cancer survivors

Purpose Chemotherapy induced peripheral neuropathy (CIPN) occurs commonly in breast cancer (BrCa) patients and contributes to falls. Depression and anxiety in cancer survivors leads to reduced quality of life, increased mortality and also increases fall risk. Therefore, we investigated the association between CIPN with depression and anxiety in BrCa survivors. Methods Data were extracted from Optum’s De-identified Clinformatics® Data Mart Database years 2012–2015. Among women, three groups were derived based on BrCa and CIPN status: BrCa+/CIPN+, BrCa+/CIPN-, and BrCa-/CIPN-. Risk ratios (RR) determined the change in risk of depression and anxiety from the 12-month pre-index period to post-index period I (0–6 months) and II (7–12 months) for each group separately. The ratio of the RR (RRR) determined if the change in risk of outcomes was different for BrCa+/CIPN + compared to BrCa+/CIPN- and BrCa-/CIPN-. Results The RR was significantly elevated for all groups (p < 0.05) in the post-index periods I (depression, RR = 1.22–1.65; anxiety, RR = 1.26–1.73) and II (depression, RR = 1.41–2.16; anxiety, RR = 1.46–2.05), with BrCa+/CIPN + exhibiting the largest RR. The RRR for depression was significantly elevated for BrCa+/CIPN + compared to BrCa+/CIPN- and BrCa-/CIPN- for post-index periods I (RRR = 1.35 and 1.33, respectively) and II (RRR = 1.53 and 1.50, respectively). The RRR for anxiety was significantly elevated for BrCa+/CIPN + compared to BrCa+/CIPN- and BrCa-/CIPN- for post-index periods I (RRR = 1.37 and 1.31, respectively) and II (RRR = 1.41 and 1.28, respectively). Conclusion Among BrCa survivors, CIPN onset is associated with a subsequent increased 12-month risk of depression and anxiety. Depression and anxiety screening should be considered in BrCa+/CIPN + survivors.
A new multilevel inverter topology based on switched-capacitor technique

This paper presents a new multilevel inverter based on the switched-capacitor technique. The topology aims for renewable energy and fuel cell applications that demand high magnitude output ac voltage. This configuration of the inverter can produce a total of thirteen voltage levels using a single DC source. The topology features voltage boosting with a triple gain of the input voltage source without utilizing a boost DC-DC converter. Furthermore, the voltages of the capacitors are self-balanced at any desired voltage level during each cycle. Therefore, auxiliary circuits are no longer needed. A comparative study of the presented inverter with the classical topologies and recently introduced topologies has been done in power switches, driver circuits, blocking voltage of the switches, and boosting the input voltage. A simple fundamental switching scheme is applied to the proposed topology to validate the viability of the topology.
Limb Ischemic Preconditioning or Dezocine Pre-Treatment will Reduce Acute Gastric Mucosal Injury in Rats

Objective: The proposal of the studying was to investigate the protective effect of Limb ischemic precondition or Dezocine pre-treatment in acute stress-related gastric mucosal injury. Methods : Forty-five Sprague Dawley (SD) male rats at 2-3 month were randomly divided into three groups: controlled group (Group C, n=15), Ischemic precondition group (Group T, n=15): rats in this group received 5 cycles of ischemic precondition of 5-5 min in their left legs; Dezocine pre-treatment group (Group D, n=15): Rats in this group received Dezocine subcutaneous injection at a dosage of 10µg/g. Rats were beheaded after 6h of cold water immerse, and stomach was taken out for Gastric injury index (GI), HE stains, and measurement of MDA, SOD, MPA. Result : (fewer Group Group Group Group D significantly Group C, (3) Lever of SOD in Group T was higher than that in Group D,(P=0.048, CI=95%). Conclusion: Both Limb ischemic preconditioning and Dezocine pre-treatment will reduce acute gastric mucosal injury by inhibiting the inflammatory response and cleaning oxygen radical. or Dezocine Pre-Treatment will Reduce Acute Gastric Mucosal Injury in Rats. Biomed
Addicted to the moon: vocal output and diel pattern of vocal activity in two Neotropical nightjars is related to moon phase

The moon phase affects the ecology and vocal activity of nightjars (Caprimulgidae). However, some studies have found contradictory results regarding the impact of the moon phase on the vocal activity of nightjars. To increase our knowledge on this topic, we monitored the vocal behavior of two Neotropical nigthjars, the Little nightjar (Setopagis parvula) and the Common pauraque (Nyctidromus albicollis), over 5 lunar cycles in the Brazilian Pantanal. We tested the relationships between the moon phase and daily vocal output (number of calls uttered) and the proportions of calling activity at dusk, midnight, and dawn. Our results suggest that moonlight stimulated the vocal output of both species, since it was between 6 and 8 times higher during full moon nights than during new moon nights. Likewise, the proportion of calling activity at midnight was significantly higher during full moon nights. In contrast, the proportion of calling activity of both species was higher at dawn during new moon nights than under the full moon. The calling activity of the Common pauraque was also higher at dusk during new moon nights. These findings might be partly related to the much lower vocal output at midnight during full moon nights and therefore higher proportions of vocal activity at dusk and at dawn under new moon scenarios. This is the first study comparing the vocal behavior of two Neotropical nightjars over different moon phases and shows that the impact of moonlight may differ between species and at a daily scale when analyzing the periods with the highest and lowest illumination. The consequences of the increase in vocal output under moonlight are unknown and should be assessed.
‘I Feel … Slightly out of Touch’: a Longitudinal Study of Teachers Learning to Teach English Pronunciation over a Six-Year Period

Recent longitudinal studies have contributed substantially to the understanding of teacher learning. Yet, research on learning to teach English pronunciation is still in its infancy with the aim of this article being the exploration of the longitudinal development of four L2 instructors’ practices and cognitions about English pronunciation pedagogy. Qualitative data were collected in three phases over six years, ranging from the beginning of a pronunciation pedagogy course into the teacher’s current professional careers. Pre- and post-course questionnaires, a course assignment, focus groups, observations, narrative frames, and semi-structured interviews were triangulated to produce detailed teacher profiles, which then provided a thorough understanding of the practitioner’s developing practices and cognitions. Findings demonstrated complex and continuous yet nonlinear and individual development, especially in two areas: (i) the teachers’ delivery of pronunciation instruction and (ii) their focus on pronunciation pedagogy. Four specific factors were also identified as impacting the developmental process of teachers’ practices and cognitions about pronunciation. In light of these findings, the article concludes with a recommendation to extend an existing framework for preparing pronunciation teachers.
Development Environment of Machine Learning for Image Classification

Machine learning is an interesting topic nowadays, it is also a subarea of artificial intelligence. An interesting thing that needs to be done in the beginning is how to configure the Development Environment (DE). In this paper, DE is configured using Acer-Notebook with jupyter notebook and Smartphone with google colab for image classification using convolution neural network method. The configuration process is easier to do on Smartphone Realme-C2 than Acer-Notebook and the best level of accuracy is epoch 100 in training and testing data obtained by Smartphone Realme-C2 are 0.70 and 0.66, while Acer-Notebook is 0.70 and 0.63.
Isolation of Adenosine and Cordysinin B from Anredera cordifolia that Stimulates CRE-Mediated Transcription in PC12 Cells

Abstract Alzheimer’s disease is a typical neurodegenerative disorder, and its prevention or treatment poses great concern in advanced countries. In our survey of numerous natural resources with neurotrophic activities, we found that Anredera cordifolia improved memory impairment and increased cyclic adenosine monophosphate (AMP) response element-mediated transcription, an important step in signal transduction for memory formation. The extracts of this food were dissolved in methanol and then partitioned with three organic solvents and water, separating into n-hexane, ethyl acetate, n-butanol, and water layers. The n-butanol layer with the strongest activity on cyclic AMP-response element-dependent transcription was fractionated using silica gel column chromatography and then the activity was monitored using preparative high-performance liquid chromatography to give adenosine and cordysinin B, respectively. Both compounds showed a concentration-dependent increase in cyclic AMP-response element-mediated transcription activity. These results suggest that both adenosine and cordysinin B may participate in improving the action of A. cordifolia on memory impairment, and these actions, at least in part, result from the activation of adenosine A1, A2A, and A2B receptors.
Effect of hot isostatic pressing on the quality of metal parts obtained by selective laser melting

In this work, an approach to improving the quality of material obtained by the method of selective laser melting is considered. The analysis of powder material of stainless steel is carried out. A number of samples were obtained with subsequent HIP-processing. The structure was analyzed, and the hardness of the obtained samples was measured before and after HIP treatment.
Incidence and survival outcomes of secondary liver cancer: a Surveillance Epidemiology and End Results database analysis

Background The global incidence and mortality rates of liver cancer, which is the second leading cause of cancer-related deaths worldwide, are increasing. However, information on its epidemiology and clinical prognosis is limited. This study aimed to characterize the epidemiology and prognostic factors of secondary liver cancer to aid in the pretreatment evaluation of the disease. Methods Patients diagnosed with secondary liver cancer between 2010 and 2014 in the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively included. Kaplan-Meier analysis and Multivariate Cox regression analysis were performed to screen for significant factors associated with secondary liver cancer. Results A total of 85,738 secondary liver cancer patients were identified; in this population, the first primary site was the lung (25.9%), followed by the colorectum, pancreas, stomach, breast, and cecum. Patients with primary tumors of the colorectum, cecum and breast had longer median survival time. Advanced age, male gender, black race, poor differentiation or lack of differentiation, regional lymph node metastases, and presence of distant metastasis were associated with poor prognosis. Conclusions In this study, novel findings on the role of the primary site and synchronous distant metastasis to specific organs in patients with secondary liver cancer were described. These findings have significant implications in clinical diagnosis and treatment, and provide a better understanding of secondary liver cancer in the general population.
Micromechanical modeling approach with simplified boundary conditions to compute electromechanical properties of architected piezoelectric composites

Architected piezoelectric composites (PCs) have recently gained interest in designing transducers and nondestructive testing devices. The current analytical modeling approach cannot be readily applied to design architected periodic PCs exhibiting elastic anisotropy and piezoelectric activity. This study presents a micromechanical (MM)-model based finite element (FE) modeling framework to predict the electromechanical properties (EMPs) of the architected PCs. As an example, the microstructure with one-dimensional (1–3 PCs) connectivity is considered with different cross-sections of fibers. 3D FE models are developed. The intrinsic symmetry of architected composite is used to derive boundary conditions (BCs) equivalent to periodic BCs (PBCs). The proposed approach is simple and eliminates the need for a tedious mesh generation process on opposite boundary faces on the MM model of architected PCs. The EMPs of 1–3 PCs calculated from the proposed micromechanics-FE models were compared with those obtained from analytical solutions (i.e. based on micromechanics theories), and FE homogenization (i.e. obtained by employing the PBCs available in the literature). A quite good agreement between the proposed modeling approach and the ones obtained using the analytical model was observed. However, an excellent agreement is observed with the MM results that employed PBCs. Hence, we have concluded that the proposed MM modeling approach is equivalent to MM models that employed PBCs. The computed enhanced effective elastic, piezoelectric, and dielectric properties and corresponding figure of merit revealed that 1–3 PCs are suitable in transducer applications.
Fertility desire and associated factors among HIV positive women attending ART clinics, Afar region, northeast Ethiopia

BackgroundThe desire of human immune deficiency virus infected person to have children in the future has significant implication for the transmission of human immune deficiency virus to sexual partner and new born. However, fertility desire has given little attention and the uptake of PMTCT services is limited. Therefore, this study aimed to assess fertility desire and associated factors among HIV positive women attending ART clinics, Afar region, northeast EthiopiaMethodologyInstitution-based cross-sectional study was conducted on 402 HIV positive women attending ART clinic in selected Hospitals in Afar region. A systematic random sampling technique was employed to identify and enroll women. Logistic regression analysis was employed to identify the factors associated with fertility desire. Statistical association was measured and p-value < 0.05 was considered statistically significant.ResultIn this study a total of 391 HIV positive were participated with a response rate of 97.3%. The prevalence of fertility desire was 63.9 % (95 % CI, 59.1 %, 68.8 %). Young age between 15–24 (AOR = 11.98, 95% CI (4.04, 35.5) and 25–34 years (AOR = 2.93, 95% CI (1.46, 5.86), women who were not had live children (AOR = 5.1, 95% CI (1.31, 20.2) and women that had 1 or 2 live children (AOR = 2.7, 95% CI (1.39, 5.27), disclose sero status to their partner (AOR = 5.89, 95% CI (2.33, 14.9) were associated with increased odds of fertility desire. However, women who use contraceptive were associated with decreased odd of fertility desire (AOR = 0.11, 95%, CI (0.05, 0.22). ConclusionThis study showed that six in ten HIV positive women attending ART clinic were had fertility desire. Young age, not having live child, and having 1 or 2 live number of children, disclosing sero status to partner, and contraceptive use were predictors of fertility desire. Therefore, efforts should be made to increase fertility desire among young HIV positive women attending ART clinic. Moreover, awareness creation on the importance of disclosing sero status to partner is mandatory as it helps to increase fertility desire.
Probiotic Substance in Combination with Zeolite Changes the Digestibility and Metabolism of Bulls

In the course of laboratory studies, we found that the porosity (in volume) of zeolite acetone is 34.4%. The sorption capacity of the studied zeolite to the Bifidobacterium longum strain together with the MRS nutrient medium was determined. As a result of the experiment, it was found that 100 g of zeolite absorbs 34 ml of nutrient medium with bifidobacteria. The optimal dose of feeding a complex probiotic preparation (CPP) – 30.5 g/day included 82% zeolite and 18% probiotic strain of Bifidobacterium longum. The coefficients of digestibility of nutrients were slightly higher in bulls from the experimental groups compared to their peers from the control group. So for dry matter, respectively, by 1.87%, 4.68 and 3.58%; crude protein by 2.22%, 5.00 and 3.48%; BEV by 1.24%, 3.19 and 2.20%. The control animals absorbed less nitrogen compared to the bulls of the I, II and III experimental groups by 14.52%, 30.14 and 21.78%. According to the use of the nitrogenous part of the rations, the animals of the experimental groups outperformed their counterparts from the control group by 2.13%, 5.00%, and 3.38%, respectively. On average, during the experiment period, the bulls of the I - III experimental groups had an advantage over the animals from the control group in absolute live weight gain by 1.4%, 14.9 and 6.7%, and in average daily weight gain by 1.4%, 14.8 and 6.7%.
Range of Resistance of Hydrobionts to Medium Contamination with Manufactured Nanoparticles

An assessment was performed to estimate ecological and biological effects of metallic and binary NPs of various chemical nature and structural characteristics. Application of rapid toxicity tests using hydrobionts of various trophic levels (E. coli, Сhlorella v. B., Paramecium c., Daphnia m. S., Danio r.) allowed to determine resistance range to NPs Ni, Pt, ZnO and CeO2. It was established that test reaction to contamination of water with NPs and development of adverse effects to phyto- and zooplankton is contingent on NPs physicochemical properties and sensitivity of hydrobionts. Concentrations of NPs not causing observed change of test reactions were determined. Chlorella v. B. was established to be the most vulnerable to contamination of medium with NPs; photosynthetic pigment quantity was determined to be the most sensitive parameter: nCeO2 L(E)С10 = 0.0007 mg/l, nNi L(E)С10 = 0.0015 mg/l, nZnO L(E)С10 = 0.0048 mg/l, nPt L(E)С10 = 0.033 mg/l. The highest resistance (L(E)С10 > 100 mg/l) to contamination shown by: E. Coli, Daphnia m. S. , Danio r. tonPt; Danio r. to NNi and nZnO, E. Coli, Paramecium c. to nCeO2; and Danior r. by the parameter ‘embryotoxicity’. The most vulnerable chains of trophic structure of communities were revealed as well as ways of disrupting food pyramid of an aquatic system. Range of resistance or range of concentrations within which biota retains resistance was shown to be an integral characteristic of NPs effects on ecosystems.
A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis

Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia and the master regulator of the hypoxic response, hypoxia-inducible transcription factor 1 (HIF1), in the regulation of genes required for lens fiber cell differentiation, structure and transparency. Here, we employed a multiomics approach combining CUT&RUN, RNA-seq and ATACseq analysis to establish the genomic complement of lens HIF1α binding sites, genes activated or repressed by HIF1α and the chromatin states of HIF1α-regulated genes. Results CUT&RUN analysis revealed 8375 HIF1α-DNA binding complexes in the chick lens genome. One thousand one hundred ninety HIF1α-DNA binding complexes were significantly clustered within chromatin accessible regions (χ 2 test p < 1 × 10 − 55 ) identified by ATACseq. Formation of the identified HIF1α-DNA complexes paralleled the activation or repression of 526 genes, 116 of which contained HIF1α binding sites within 10kB of the transcription start sites. Some of the identified HIF1α genes have previously established lens functions while others have novel functions never before examined in the lens. GO and pathway analysis of these genes implicate HIF1α in the control of a wide-variety of cellular pathways potentially critical for lens fiber cell formation, structure and function including glycolysis, cell cycle regulation, chromatin remodeling, Notch and Wnt signaling, differentiation, development, and transparency. Conclusions These data establish the first functional map of genomic HIF1α-DNA complexes in the eye lens. They identify HIF1α as an important regulator of a wide-variety of genes previously shown to be critical for lens formation and function and they reveal a requirement for HIF1α in the regulation of a wide-variety of genes not yet examined for lens function. They support a requirement for HIF1α in lens fiber cell formation, structure and function and they provide a basis for understanding the potential roles and requirements for HIF1α in the development, structure and function of more complex tissues.
Alginate Oligosaccharides Alleviate the Damage of Rice Leaves Caused by Acid Rain and High Temperature

Alginate oligosaccharides (AOS) are known for functions in regulating plant growth and stress resistance. This study investigated the damage on rice leaves caused by acid rain (AR) and high temperature (HT) simultaneously, as well as the alleviating effect of AOS on these stresses. The results show that plant biomass and antioxidant enzyme activities (AEAs) after AR treatment reduced more severely under HT conditions than normal-temperature conditions. Both AR and HT triggered the accumulation of reactive oxygen species (ROS) in rice leaves. The suppressing effects of AR and HT were individual in most cases, except for AEAs. Microscopic analysis showed that pH 2 AR and HT injured leaf epidermis, particularly the bulliform cells, the veins and interveinal regions. Spraying AOS resulted in a slight elevation of biomass, a significant increase in AEAs and a remarkable decline in ROS concentrations under HT conditions with AR. Besides, the chlorophyll a contents of a leaf after pH 2 AR plus AOS treatment under HT conditions remained 66.1% of that after pH 7 treatment under normal-temperature conditions. Moreover, AOS protected the integrity of leaf tissue even after pH 3 treatment. Taken together, the above results suggest that AR and HT inhibited AEAs, led to the accumulation of ROS and damaged rice leaf. However, foliar applying AOS enhanced AEAs, scavenged ROS, and thus alleviated the stress induced by HT and AR.