Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Efficiency Wireless Power Transfer System for Electric Vehicle Applications

In this brief, a high-efficiency wireless power transfer (WPT) system for electric vehicle charging application is studied and implemented. Series–series resonant topology with RF feedback design is adopted as the WPT dc–dc stage due to the advantages of circuit simplicity, easy analysis, and control. A 500-W laboratory prototype is built and tested to verify the feasibility of the proposed design. According to the experimental results, high wall-to-battery efficiency and unity power factor can be achieved over an air gap of 15 cm and maximum sliding distance of 10 cm under various power conditions and universal input voltage from 90VAC to 264VAC.
Adaptive strategies in western Panama

Abstract An example of prehistoric ‘adaptive radiation’ in western Panama is explored by comparing two allotropic types of tropical forest agriculturalists: those occupying the Bocas del Toro province on the Atlantic side of the isthmus and those living in Chiriqui province on the Pacific side. The two populations appear to be descended from common ancestors who once settled the highlands separating these two coastal provinces. Using the method of controlled comparison and the biological concept of radiation, the possible effects of the vegeculture and seed culture agricultural systems of these peoples on their social and political arrangements are explored. The model developed during the course of discussion is parallel to models built by biogeo‐graphers to deal with processes of migration, colonization, population change, divergence and adaptation in the humid versus the seasonal tropics.
Kabuki syndrome as a cause of non‐immune fetal hydrops/ascites

Kabuki syndrome (MIM 147920) is a well‐described, multiple congenital anomaly syndrome characterized by growth and developmental delay, cardiac, renal, and vertebral anomalies, as well as persistent fetal finger pads and distinct facial features. Facies are characterized by long palpebral fissures with eversion of lateral third of the lower eyelid, resembling the “Kabuki make‐up” theatre genre after which the syndrome is named. Kabuki syndrome is estimated to affect 1/32,000 births, with 55–80% of patients showing nonsense or frameshift mutations in the KMT2D (MLL2) gene, which encodes a histone transferase located on chromosome 12q. Additionally, owing to the heterogeneous nature of Kabuki syndrome, a smaller number of diagnosed patients have been identified with mutations or deletions in KDM6A (a component of the same transcriptional complex as KMT2D) with no mutations in KMT2D, or as those diagnosed with Kabuki syndrome and without alterations in either KMT2D or KDM6A. Diagnosis of the syndrome in newborns and infants is difficult, as the facial features are not as evident as in toddler‐ or childhood. There are no known “tell‐tale” signs of Kabuki syndrome prenatally, and there are no reports of common, specific findings in fetuses that might suggest the diagnosis. We present here two infants who presented with prenatal hydrops/ascites, who were subsequently diagnosed with Kabuki syndrome. Although relatively non‐specific, we suggest that Kabuki syndrome be added to the list of genetic syndromes that are suspected in cases of prenatal hydrops, review the molecular etiology of Kabuki syndrome, and broaden the phenotype of this well‐described disorder. © 2016 Wiley Periodicals, Inc.
La Nueva Teoría del Crecimiento: ¿Nada Nuevo Bajo el Sol?

A primera vista la historia parece corriente. En 1957, Robert Solow, un profesor del MIT, propuso una teoria del crecimiento que parecia tener varias ventajas al tiempo sacaba al campo nuevo, y poco estudiado, de la teoria del crecimiento del lerreno incierto y heterodoxo en el que lo habian hecho nacer Harrod y Domar al final de los anos 30's; le daba -en forma elegante y sencilla- una fiindamentacion neo-clasica, que coincidia con la naciente expansion del programa de investigacion neo-walrasiano a todos los ambitos de la teoria economica, y le garantizaba, ademas, un caracter predictivo y cuantitativo que la anterior teoria ni siquiera habia pretendido tener. Esto ultimo fue definitivo para su rapido exito el modelo de Solow no solo intentaba explicar el crecimiento economico, sino que generaba predicciones corroborables sobre las tasas de crecimiento, la contribucion de los factores productivos al mismo, y la tendencia a la igualacion de las relaciones capital/trabajo de economias definidas en un contexto competitivo. Los ajustes econometricos logrados con los datos sobre el crecimiento del producto per*capita de los Estados Unidos en el periodo 1909-1949, ademas de corroborar el poder predictivo del modelo, le daban una ventaja adicional la capacidad de captar la impresionante estabilidad del crecimiento del producto per-capita de los Estados Unidos para el periodo mencionado mas arriba. Pero el exito del modelo de Solow iba mucho mas alla de su simple poder predictivo: se trataba de un modelo ejemplar en el sentido epistemologico. Lucas (1988) senala tres caracteristicas fundamentales que harian de la propuesta de Solow un modelo ejemplar de teoria economica exitosa %. ) como un ejemplo de la forma (.) que deben tomar teorias agregadas utiles, como una oportunidad de explicar exactamente que nos pueden decir teorias de este tipo que teorias de otras clases no pueden, y como una posible teoria del desarrollo economico. En este ultimo aspecto la teoria falla miserable, pero tambien sugestivamente”. (Lucas, 1988, 6*7). Por ello, el exito del modelo y su larga supervivencia estaban no tanto en su manifiesta capacidad para ajustarse a los datos sobre crecimiento provenientes de las estadisticas de diversos paises, sino en su poder de generar un modelo valido, tanto en lo teorico como en lo empirico, para un nuevo campo de la teoria economica. El modelo de Solow era predictivo, agregado, estable, sencillo, y ademas de todo, podia exhibir un digno origen neo-clasico en su fundamentacion teorica: es muy dificil encontrar un exito mejor fundamentado en el desarrollo reciente de la teoria economica. El pero viene, sin embargo, dos decadas mas tarde, y no sin una cierta ironia, pues llega de la mano de lo que fuera uno de los fuertes del modelo en sus primeros anos su poder predictivo.
Gastrointestinal Stromal Tumor A Clinicopathological Study

Background Gastrointestinal stromal tumours (GIST) are KIT-expressing signal driven mesenchymal tumours of the gastrointestinal (GI) tract. Currently the diagnosis of these tumours is based on study of histo morphologic features and Immunohistochemical (IHC) demonstration of CD117 which is essential to distinguish it from other mesenchymal tumours of GI tract. Surgical resection followed by adjuvant treatment of Tyrosine kinase inhibitor has got encouraging outcomes even in chemotherapy-resistant advanced GIST. AimTo present the clinical, radiological, histopathological and IHC features in seventeen cases. Material and MethodsMedical records of all seventeen patients were reviewed for their clinical presentation, laboratory investigations, radiological, histopathological and IHC findings in detail. Results In a series of 17 patients, eight were males and nine females. Mean age was 49 years with pain abdomen as the commonest symptom of presentation. Three of the 17 patients underwent only core needle biopsy, while fourteen operated specimens were available for gross, microscopic and IHC analysis. Small intestine was the commonest site of occurrence of the tumor. IHC marker CD 117 was positive in all the cases while CD 34 in three cases only. ConclusionGIST is a rare tumor. Histopathology and IHC are essential and together help to distinguish it from other mesenchymal tumours of the GI tracts. In this study of series of 17 cases of GISTs collected over a period of 10 year, small intestine was the commonest site.
Observer-based L2–L∞ control for a class of stochastic systems with time-varying delay

This paper is devoted to the problem of L2–L∞ control for a class of stochastic time-delay systems via observer-based feedback control. The considered observer contains no time-delay. The purpose is to design an observer-based feedback stabilizing controller such that the augmented closed-loop system is stochastically asymptotically stable with a prescribed L2–L∞ performance satisfied. Based on the stochastic stability theory, a delay-dependent sufficient condition is derived in terms of linear matrix inequalities (LMIs). The observer and controller design method is proposed, while the corresponding explicit expression for the observer and controller gain matrices is also given. Finally, numerical examples and simulation results are included to illustrate the effectiveness of the proposed results.
High-resolution NMR in the native state

High-resolution NMR provides increasing possibilities to probe biomolecular structure in the native state. In this issue, Luchinat and Banci [IUCrJ (2017), 4, 108–118] discuss progress on using in-cell NMR in prokaryotic and eukaryotic cell preparations.
The Turnaround ERP Project: Strategies and Issues

A case study of an ERP project within a Fortune 100 company in the transportation industry is used to identify the strategies which facilitate a turnaround ERP project. The case study was developed using in-depth interviews with the President and the Chief Information Officer of the firm. The strategies described in this paper include project sponsorship, top management accountability, change control procedures, customization decision-making, measurement of project outcomes, management perception of the value of the ERP system, vendor relationship, and organizational change. To facilitate the turnaround project, top management involvement and accountability were critical. Modifications to the ERP system were minimized, and accountability mechanisms to monitor project outcomes— both in time and cost— were established.
A Fast and Reliable Broadcast Service for LTE-Advanced Exploiting Multihop Device-to-Device Transmissions

Several applications, from the Internet of Things for smart cities to those for vehicular networks, need fast and reliable proximity-based broadcast communications, i.e., the ability to reach all peers in a geographical neighborhood around the originator of a message, as well as ubiquitous connectivity. In this paper, we point out the inherent limitations of the LTE (Long-Term Evolution) cellular network, which make it difficult, if possible at all, to engineer such a service using traditional infrastructure-based communications. We argue, instead, that network-controlled device-to-device (D2D) communications, relayed in a multihop fashion, can efficiently support this service. To substantiate the above claim, we design a proximity-based broadcast service which exploits multihop D2D. We discuss the relevant issues both at the UE (User Equipment), which has to run applications, and within the network (i.e., at the eNodeBs), where suitable resource allocation schemes have to be enforced. We evaluate the performance of a multihop D2D broadcasting using system-level simulations, and demonstrate that it is fast, reliable and economical from a resource consumption standpoint.
A chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease

We describe the isolation of the gene encoding a 22-kDa antigen from Borrelia burgdorferi, the etiologic agent of Lyme disease. The p22 gene is 582 nucleotides in length and encodes a protein of 194 amino acids with a predicted molecular mass of 21.8 kDa. The leader signal sequence of P22 consists of a positively charged short amino terminus, a central hydrophobic domain, and at the carboxyl terminus, a cleavage site that is presumably recognized and cleaved by a B. burgdorferi signal peptidase. P22 has 98.5% homology with the recently described B. burgdorferi protein IpLA7. P22 is processed as a lipoprotein, as demonstrated by [3H]palmitate labeling. Pulsed-field gel electrophoresis showed that p22, like LA7, is localized to the linear chromosome of B. burgdorferi. Examination of sera from patients with Lyme disease revealed that antibodies to P22 are rarely detected in patients with early-stage disease characterized by erythema migrans (2 of 20), and 35% of the patients with late-stage disease characterized by arthritis (9 of 26) developed antibodies to P22. Sera from patients with syphilis did not react with P22. When patients with late-stage disease were tested for their antibody reactivities to four other outer surface proteins (OspA), OspB, OspE, and OspF), 75% of these patients responded to P22 or to one or more outer surface proteins.
Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells

Metastasis is one of the main causes of poor prognosis for hepatocellular carcinoma (HCC), which has been linked to cell-death resistance. Autophagy is an important survival mechanism under conditions of cell stress. We hypothesized that autophagy may play a role in HCC metastasis due to its prosurvival effect. Highly metastatic HCC cell lines with stable autophagy inhibition were established via lentivirus-mediated silencing of BECN1 and ATG5 genes. Mouse models of pulmonary metastasis were then developed using the cells with or without autophagy inhibition. The analysis of lung metastasis by histopathological examination and small animal imaging showed that autophagy inhibition significantly decreased the incidence of pulmonary metastases in vivo. Further invasion, migration, detachment, lung colonization, and epithelial-mesenchymal transition (EMT) assays indicated that autophagy inhibition did not affect cell invasiveness, migration or EMT but attenuated the anoikis-resistance and lung colonization of HCC cells. Investigation of the molecular mechanisms underlying showed that the autophagy-inhibition-mediated anoikis-resistance attenuation was associated with the regulation of apoptotic signaling. As autophagy inhibition was shown to be able to suppress HCC metastasis, an autophagy-based HCC tissue-specific target therapy system (AFP-Cre/LoxP-shRNA) was constructed. In vitro and in vivo analyses showed that the system was able to efficiently inhibit autophagy of HCC cells and tissue in a tissue-specific manner. Further in vivo metastasis assay showed that intratumoral administration of the system could significantly suppress lung metastasis. Together, our findings suggest that autophagy may be involved in HCC metastasis through facilitating anoikis resistance and lung colonization of HCC cells. Autophagy-based HCC tissue-specific target therapy may be a new strategy for the management of HCC metastasis.
EFFECT OF TEMPERATURE ON GROWTH AND VIRULENCE OF PASTEURELLA PESTIS

Fukui et al. (1959; 1960) reported previously that Pasteurella pestis from cultures grown at 5 C consistently manifested lowered virulence. It was further demonstrated that subsequent incubation of such cultures at 37 C for 6 to 8 hr restored maximal virulence in the absence of significant cellular multiplication. Since previous studies were performed with a complex medium under one set of physical and chemical conditions, studies were undertaken to define the physical and nutritional requirements for the restoration of virulence.
Outcome of Charnley total hip replacement across a single health region in England.

Sir, The article in the July 1999 issue by Fender, Harper and Gregg 1 entitled ‘Outcome of Charnley total hip replacement across a single health region in England’ was so interesting that I am stimulated to point out some of its implications and also request some amplification. American subscribers to the Journal are now faced with revolutionary changes in, and evolving plans for, health care. They bear directly on the subject. There were 1198 ‘Charnley’ total hip replacements (THR). Were other types of THR performed? Of these patients 19% were under 60 years of age. How many were aged 55 to 60 years? Charnley’s large series included those in that age group. How many were under the age of 30 years since nowadays THR is carried out, even if only occasionally, in the young adult? Did the 1198 include any primary THRs in elderly patients with acute fractures? What was the prevalence of THR in the Trent population? Is there in Trent a ‘specialist hospital’ as mentioned in Table V? It should be recalled that Charnley in his first decade of success with THR reported that “osteoarthritis was the commonest indication for THR with a minority of about 20 percent comprising rheumatoid arthritis and ankylosing spondylitis. ” 2 He also reported that “nearly all” of his thousands of patients operated on between 1960 and 1970 were over 55 years of age. Does this mean that under the NHS in the UK there has been little expansion of the application of THR (as in the USA) to other diagnoses and younger individuals? Charnley also reported a success rate of 90% while the authors record a lower rate of 73% if the hip score is the parameter. Exactly what does this mean? Is it that Charnley’s overall regimen only included better prospects? Orthopaedic surgeons in the USA are beset with existing restrictions on health care in general and on THR in particular. They would be well served if there was on record good evidence, in more detail than is provided in the cited article, of the epidemiological aspects of THR as illustrated in the questions asked above (and other analagous queries). While the authors are to be commended for initiating and completing this study, I would urge
DC-bus voltage control of three-phase PWM converters connected to wind powered induction generator

This paper presents a performance analysis of wind-powered self-excited induction generator (SEIG) and a vector-controlled PWM converter. Three-phase voltage-source converters are the building blocks of a large number of power electronic systems. The origin of difficulties in the control of the above converters is in their nonlinear nature. The PWM current control technique is used to derive the switching signals for the converter. Closed-loop control of the converter utilizes a conventional proportional integral (PI) controller. In order to examine the dynamic performance of the system, its model is simulated and results are analyzed. The simulation results and experimental results are presented. The experimental results were obtained using Dspace DS1104 R&D controller board which confirms good performance of the proposed control system and agree with the simulation results. The results verify the validity of the proposed model and show practical promise in renewable energy applications.
Urinary tract infections in intensive care unit patients - a single-centre, 3-year observational study according to the INICC project.

BACKGROUND Urinary tract infections (UTI) in patients with urinary catheters could be a serious complication of hospitalisation in the intensive care unit (ICU). METHODS A prospective study (01.01.2012-31.12.2014) was conducted in the 20-bed ICU of the University Hospital in Wroclaw, Poland. The frequency (density, incidence) and aetiology of UTI as well as prophylactic method compliance were estimated in patients of the ICU according to the INICC project. RESULTS Among 1261 ICU patients, urinary tract infections were diagnosed in 91 (7%). The incidence index was 7.25/100 admissions to the ICU. CA-UTI constituted 36% of the device-associated, healthcare-associated infections (n = 255). A urinary catheter was used in 92.21 ± 4.51% of patients during 14,006 patient-days and 12,917 urinarycatheter- days. The density of CA-UTI/1000 catheter-days was 6.44, 6.84, 7.16 during the years 2012, 2013, and 2014, respectively. The main pathogens of CA-UTI were Enterococcus spp. (22%), Acinetobacter baumannii (20%), Klebsiella pneumoniae (18%), Pseudomonas aeruginosa (13%), and Candida spp. (13%). Only in four elements of the "Urinary Catheter Bundle" was 100% compliance noted. CONCLUSIONS In the observed period of time, the incidence of CA-UTI was higher than in the INICC (2014) report and the NHSN/CDC (2012) report. Analysis of compliance with a "Urinary Catheter Bundle" to prevent UTI shows low implementation of preventative methods with the INICC protocol.
The human cytomegalovirus UL37 immediate-early regulatory protein is an integral membrane N-glycoprotein which traffics through the endoplasmic reticulum and Golgi apparatus

The human cytomegalovirus (HCMV) UL37 immediate-early gene is predicted to encode a type I membrane-bound glycoprotein, gpUL37. Following expression of the UL37 open reading frame in vitro, its signals for translocation and N-glycosylation were recognized by microsomal enzymes. Its orientation in the microsomes is that of a type I protein. gpUL37 produced in HCMV-infected human cells was selectively immunoprecipitated by rabbit polyvalent antiserum generated against the predicted unique domains of the UL37 open reading frame and migrated as an 83- to 85-kDa protein. Tunicamycin treatment, which inhibits N-glycosylation, increased the rate of migration of the UL37 protein to 68 kDa, verifying its modification by N-glycosylation in HCMV-infected cells. Consistent with this observation, gpUL37 was found to be resistant to digestion with either endoglycosidase F or H but sensitive to peptide N-glycosidase F digestion. These results suggested that gpUL37 is N-glycosylated and processed in both the endoplasmic reticulum (ER) and the Golgi apparatus. Direct demonstration of passage of gpUL37 through the ER and the Golgi was obtained by confocal microscopy. gpUL37 colocalized with protein disulfide isomerase, a protein resident in the ER, and with a Golgi protein. Subcellular fractionation of HCMV-infected cells demonstrated that gpUL37 is an integral membrane protein. Taken together, our results demonstrate that the HCMV gpUL37 immediate-early regulatory protein is a type I integral membrane N-glycoprotein which traffics through the ER and the Golgi network.
Extrinsic and intrinsic coagulation pathway, fibrinogen serum level and platelet count in HIV positive patients.

Infection with human immunodeficiency virus (HIV) is a progressive condition which may cause endothelial dysfunction and liver damage leading to coagulopathy. With adventure of highly active antiretroviral therapy (HAART), life expectancy has prolonged in HIV positive patients but several acquired immunodeficiency syndrome (AIDS)-related conditions such as coagulopathies are responsible for associated morbidity and mortality. This study aimed to evaluate the extrinsic and intrinsic pathways of coagulation, serum level of fibrinogen and platelet count in HIV positive patients and compare it with negative healthy individuals. Through a case-control study, 114 HIV seropositive patients were compared with 114 seronegative samples in terms of hematological and other coagulation parameters. Mean age of study patients was 37.48 years. Intra venous drug abuse was the most common route of infection transmission with a prevalence of more than 50%. HIV route of transmission had a direct relationship with PTT abnormal levels (P<0.0001). However, this relationship was not significant for PT values. Stages of HIV disease and administration of HAART did not reveal any significant relationship with PT and PTT. There was also a statistically significant correlation between CD4+< 200 and PT in case group (P=0.008). On the other hands, in control group, CD4+ had a weak relationship with PTT (P=0.02) and an inverse correlation with serum fibrinogen (P=0.013). Hematological parameters and serum fibrinogen are decreased in HIV positive patients especially in direct relation with CD4+ cell count<200 cell/µl. PT and PTT abnormal values are also more prevalent in this population.