Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and In Vitro Evaluation of Buccal Effervescent Tablet Containing Ropinirole Hydrochloride

The buccal delivery is an attractive route to improve the clinical efficacy of ropinirole hydrochloride (RH) for the treatment of Parkinson and restless syndrome since this drug undergoes extensive first-pass effect, which has only 50% bioavailability after oral administration. The purpose of this study was to develop and optimize the formulation of fast disintegrating buccal effervescent tablets of RH using four types of superdisintegrants. The direct compression method was used to develop four different formulas containing RH using Kyron T-314, crospovidone, croscarmellose sodium, and sodium starch glycolate separately as a superdisintegrant. Sodium bicarbonate and citric acid were added to the formulations to produce effervescence, while sodium carbonate was used as a pH adjusting agent. All the prepared formulas were evaluated, in terms of weight variation, friability, content dose uniformity, hardness, disintegration, and dissolution test. The best formulation was selected for the subsequent study. The obtained results from pre-compression studies were in acceptable range according to British Pharmacopoeia. All formulas passed through the quality control test and significant difference (P < 0.05) was observed for the formula four compared to other formulas, due to the presence of Kyron T-314 as a superdisintegrant in formulation number 4. RH cloud be prepared as a buccal effervescent tablet and superdisintegrant provide fast disintegration of the tablet to exert rapid action.
Changes in biochemical parameters of a broiler chicken line with cold-induced ascites

Received: 31 Jun. 2019, Accepted: 12 Sep. 2019, Published online: 26 Dec. 2019. Abstract Ascites syndrome (AS), caused by an imbalance between high oxygen demand and its supply by cardiopulmonary system in broiler chickens, is a major problem in the broiler industry worldwide. An experiment was designed to investigate the differences in biochemical parameters between the ascitic and healthy chickens in a pure broiler sire line under cold conditions. A total of 817 one-dayold mixed-sex chickens from 71 half-sib families were grown and AS was induced on day 21 using a cold temperature model. On the 32 day of the trial, blood samples from five birds per sire family were collected and blood parameters (hematocrit percentage and serum metabolites including, glucose, total protein, albumin, triglycerides, cholesterol, high-density lipoprotein cholesterol (HDL), calcium, magnesium, phosphorus, alanine aminotransferase, aspartate aminotransferase, malonedialdehyde and total antioxidant status) were measured. The results showed that the male birds were more sensitive to AS than the female birds. Hematocrit percentage of the ascitic chickens was higher than the healthy chickens (P<0.0001). In both sexes, the ascitic birds showed higher right ventricle/total ventricle ratio (RV/TV) than the healthy birds (P<0.0001). The concentrations of serum HDL and cholesterol in the ascitic male birds were significantly lower than that of the nonascitic male birds. Reduction of serum cholesterol in ascitic birds may be due to its use for the synthesis of corticosterone under cold stress conditions and ascites. In this work, the traits were measured after the occurrence of ascites. Therefore, traits such as RV/TV, hematocrit, HDL and cholesterol could be useful only in diagnosis of birds that are developing AS. Since it is shown that the values of these traits are different between the healthy and ascitic chickens before the start of AS, these could be potential predictors of AS. Thus, they may be useful in designing breeding programs to produce more AS-resistant birds.
The relationship between strains of Fusarium graminearum schwabe causing crown rot of various gramineous hosts and stalk rot of maize in Queensland

The fungus Fusarium graminearum is shown to have a wide host range on gramineous plants in Queensland. Isolates from hosts other than maize when inoculated onto wheat seed were capable of causing the disease known as crown rot in resulting plants. The same disease was reproduced by wheat isolates in other gramineous hosts including canary grass (Phalaris canariensis), barley, and rye but oats was only slightly susceptible. No symptoms typical of field infection could be reproduced in maize. Root rot occurred in linseed. The perfect state of the organism as it occurs in Queensland is described and identified as Gibberella zeae. This was reproduced experimentally, easily in the case of maize isolates but only with some difficulty with isolates from other hosts. The occurrence in Queensland of pathogenic races of Gibberella zeae is postulated.
Blood pressure measurement by oscillometric and auscultatory methods in normotensive pregnant women.

OBJECTIVE to compare blood pressure values obtained by auscultatory and oscillometric methods in different gestational periods, considering cuff width. METHOD it is a cross-sectional and quasi-experimental study approved by the Research Ethics Committee. The sample consisted of 108 low-risk pregnant women. Blood pressure measurements were performed in gestational periods of 10-14, 19-22 and 27-30 weeks. RESULTS The oscillometric device presented values similar to the auscultatory method in systolic blood pressure, but overestimated diastolic blood pressure. Underestimation of blood pressure occurred when using the standard width cuff rather than the correct width cuff in both measuring methods. CONCLUSION Verification of brachial circumference and use of adequate cuffs in both methods are indispensable to obtain reliable blood pressure values in pregnant women. We recommend performance of additional studies to evaluate diastolic blood pressure overestimation by the Microlife 3BTO-A.
Compositional changes and spoilage in fish ‐ an introduction

Presents the compositional and spoilage changes in fish ‐ useful for determining the freshness for eating. Chemical and microbiological methods are focused on. Breakdowns in chemical components lead to detectable changes ‐ odour, flavour and texture. Changes to the fats, protein, nucleotides, non‐protein nitrogen compounds and enzymes are examined. These means are more valid when dealing with preserved and frozen fish and can give accurate assessment as to fish quality.
THE EFFECT OF ORGANIC ACID MARINATION ON TENDERNESS, COOKING LOSS AND BOUND WATER CONTENT OF BEEF

Longissimus muscle obtained from beef carcasses was used in this research. Initially, 0.596, 1.0% and 1.5% lactic and citric acid solutions were prepared. Meat was marinated in these solutions (1:4 w/v) in polyethylene bags at 4C for 72h. Bound water, pH, weight gain, cooking loss and Warner Bratzler shear (WBS) were evaluated. Differential Scanning Calorimetry (DSC) was used to determine the bound water content in meat samples. The latent heat of melting (ΔHm) and bound water were found to be functions of moisture content of marinated meat. There was a significant decrease in pH due to marination. Compared to lactic acid, the samples marinated with citric acid held less water. The WS values in control samples were higher than in marinated samples. Cooking loss was lower in samples marinated with lactic acid compared to citric acid marinated samples.
A STUDY OF BEER STALING USING CHEMILUNINESCENCE ANALYSIS

The chemiluninescence (CL) analysis has been used to study beer staling. Several types of commercial Japanese beers were stored at 37°C and their CL development analysed at 60°C. The CL level in beer developed as the beer was stored to reach a maximum level and then decreased. The sum of the CL intensities for the first 1 hour showed a good relationship with staling degree as assessed in mean panel scores. It is postulated that the deterioration rates of beers might be assessed from the CL producing patterns in the fresh beers before storage. The presence of sulfite in beer depressed the CL production during its storage indicating that there is some contribution of sulfite to flavour stability due to its inhibitory effect on radical reactions in beer.
Effects of photoperiod and paclobutrazol on growth dynamics of petioles in strawberry (Fragaria x ananassa)

Petiole elongation of strawberry plants (Fragaria × ananassa) is modified by photoperiod, and gibberellins may mediate this response. To test the relationship further, we measured petiole growth dynamics under short and long days, in comparison with responses to paclobutrazol, which reduces gibberellin biosynthesis. Growth rate in short days was lower after 2 days, and at its maximum was 60% of long-day controls. Petiole length at maturity was 75%, and was accounted for primarily by decreased cell length. Subsequent leaves showed similar patterns, but in the third leaf, cell number was also reduced. Petiole growth rate after treatment with paclobutrazol (5 mg plant–1) was maximal at 2 days, 44% of the control maximum at day 7. Mature length was 30% of controls, again due to reduced cell length. Second leaves had even more severely reduced growth rates. Increasing paclobutrazol concentration over the range 0.025–1.0 mg progressively reduced growth, but a gibberellin-independent component accounted for 20% of elongation. Effects of combined paclobutrazol and photoperiod treatments were additive. The normal short-day response therefore occurred in paclobutrazol-treated plants with already slowed growth and reduced capacity for gibberellin synthesis. We conclude that assessment of the function of gibberellins requires direct measurement of gibberellins in petioles during growth.
Control mechanisms for vitellogenin synthesis in mosquitoes

Earlier investigations of the hormonal control of vitellogenin (egg‐yolk protein) synthesis in mosquitoes relied on microsurgical manipulations to identify organs that secrete the various hormones that stimulate or inhibit vitellogenesis. Advances in the last 10 years, using radioimmunoassays, HPLC, mass spectrometry and tissue‐culture incubations, have shown that the control mechanism involves a complex interaction between ecdysteroids, juvenile hormones and peptide hormones.
Diversity in Apomictic Populations of Paspalum simplex Morong

Fil: Brugnoli, Elsa Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Agrarias; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Nordeste. Instituto de Botanica del Nordeste (i); Argentina
Limiting factors for phytoplankton growth in subtropical reservoirs: the effect of light and nutrient availability in different longitudinal compartments

Abstract Limited information is available on the interactions between environmental factors and algal growth in tropical and subtropical aquatic systems. We investigated the relationships between algal biomass (measured as chlorophyll, Chl-a) and light, total phosphorus (TP) and total nitrogen (TN) in longitudinal zones of subtropical reservoirs. We studied the seasonal variation of water variables in Itupararanga Reservoir (Brazil) and compared the results with 16 other subtropical lakes and reservoirs. The longitudinal zones in Itupararanga Reservoir were considered statistically different (p < 0.05, MANOVA). From the riverine zone to the dam region of the reservoir, Spearman Correlation Test suggested that light limitation and TP limitation tended to decrease and increase, respectively. Although nitrate concentrations were high (>400 μg/L), the Spearman coefficients between Chl-a and TN and the TN:TP ratios (11:1 < TN:TP < 35:1) indicated that nitrogen may be co-limiting algal growth in the studied water body. Putting Itupararanga in a regional context allowed assessment of potential influences of land use on trophic state. Within the subtropical dataset, TP explained a greater percentage of variance in Chl-a (R2 = 0.70) than TN (R2 = 0.17). The main land use type within the reservoirs drainage area significantly influenced the concentrations of TP, TN, and Chl-a (p < 0.05, MANOVA), with different relationships between nutrients and chlorophyll in forested (R2 = 0.12–0.33), agricultural (R2 = 0.50–0.68) and urban (R2 = 0.09–0.64) watersheds. Comparisons with literature values and those from reservoirs with less altered watersheds indicated that Itupararanga Reservoir is reaching the mesotrophic–eutrophic boundary, and further nutrient enrichment could cause water quality degradation.
New information on the feeding habits of the percomorph Rhenanoperca minuta, together with a short look at other fish species from the Eocene Messel Formation of Germany

appler Forage remains were studied in the digestive tracts of four Messel fish species ( Rhenanoperca minuta , Thaumaturus intermedius , Cyclurus kehreri , Atractosteus messelensis ). They were found in only 4% of all samples. Particular attention was paid to R. minuta . Herein, depending on the investigation method, between 0.7% and 13% of the samples contained conspecific prey fish and/or prey fish remains. In total 1.6% contained remains of amphipod shrimps. Concerning T. intermedius , prey (arthropod) remains could be found only in one sample (3.4%). Similarly, only one (6.6%) of the bowfins ( C. kehreri ) and none of the gars ( A. messelensis ) contained such remains. The pharyngeal jaws of R. minuta exhibit two basic types of dentition. One is characterized by strong, flattened (“molariform”) pharyngeal teeth, and the other by more delicate and slender (“papilliform”) ones. This polymorphism may be indicative of a beginning or advancing speciation. The different morphotypes probably originated in adjacent water bodies (allopatric) rather than in Lake Messel itself (sympatric). The results were discussed with particular attention to extant comparable species. The high rate of evacuated digestive tracts in R. minuta very probably results from a shortage of suitable prey, and possibly also from environmental restrictions. For the other species, different factors, like diurnal or seasonal fluctuations may have played a more important role. For R. minuta , a diet switch from predominantly arthropods to fish, especially a switch to T. intermedius as a main prey, can be discarded. Rather there appears to have been a gradual transition from soft­bodied arthropods to gastropods, as known from comparable recent species, even actual though direct evidence (gastric or intestinal contents, or even co­occurrence with abundant gastropods) could not observed among the investigated
The effect of solanine on the membrane potential of mitochondria in HepG2 cells and [Ca2+]i in the cells

To observe the effect of solanine on the membrane potential of mitochondria in HepG2 cells and [Ca2+]i in the cells, and to uncover the mechanism by which solanine induces apoptosis. HepG2 cells are double stained with and Fluo-3/AM, and both the change in membrane potential of mitochondria and that of [Ca2+]i in the cells are observed using LCSM. The results of double staining with TMRE and Fluo-3/AM show that solanine can lower membrane potential and increase the concentration of Ca2+ in the cells Solanine opens up the PT channels in the membrane by lowering the membrane potential, leading to Ca2+ being transported down its concentration gradient, which in turn leads to the rise of the concentration of Ca2+ in the cell, turning on the mechanism for apoptosis.
APLICAÇÃO DA FERRAMENTA PDCA COMO METODOLOGIA ATIVA EM UMA DISCIPLINA DE LÓGICA NO CURSO DE ENGENHARIA

A educacao tradicional por diversas vezes esta associada a falta de interesse dos discentes no que diz respeito a aprendizagem. Tem-se discutido muito sobre as novas abordagens de aprendizagem a fim de reverter tal situacao. As metodologias ativas surgem com o intuito de despertar o interesse dos alunos com uma nova proposta de aprendizagem. Portanto, o objetivo desse projeto e aplicar a ferramenta PDCA (Plan – Do – Check – Act) como uma metodologia ativa na disciplina de Tecnicas Computacionais – Logica de Programacao nos cursos de Engenharia da Universidade de Taubate – UNITAU, por se tratar de uma disciplina que envolve raciocinio logico e apresentar um alto grau de dificuldade de aprendizagem por parte dos discentes. Com este trabalho, pretende-se avaliar o grau de satisfacao dos discentes com a aplicacao da ferramenta PDCA. Assim, espera-se contribuir com a proposta da aplicacao desta metodologia em sala de aula, mostrando-a como um diferencial na reducao das duvidas e sendo mais interessante para os discentes, contribuindo para o processo de aprendizagem.
Nutritional and physiologic significance of α-lactalbumin in infants

α-Lactalbumin is the major protein in breast milk (20 -25% of total protein) and has been described to have several physiologic functions in the neonatal period. In the mammary gland, it participates in lactose synthesis, thereby creating an osmotic “drag” to facilitate milk production and secretion. α-Lactalbumin binds divalent cations (Ca, Zn) and may facilitate the absorption of essential minerals, and it provides a well-balanced supply of essential amino acids to the growing infant. During its digestion, peptides appear to be transiently formed that have antibacterial and immunostimulatory properties, thereby possibly aiding in the protection against infection. A novel folding variant (“molten globule state”) of multimeric α-lactalbumin has recently been discovered that has anti-infective activity and enhances apoptosis, thus possibly affecting mucosal cell turnover and proliferation. Cow milk also contains α-lactalbumin, albeit less than human milk (2-5% of total protein in bovine milk), and protein fractions enriched with α-lactalbumin may now be added to infant formula to provide some of the benefits of human α-lactalbumin.
Milky Disease Bacterium as a Stressor to Increase Susceptibility of Scarabaeid Larvae to an Entomopathogenic Nematode

Abstract Mortality of Cyclocephala hirta by the entomopathogenic nematode Heterorhabditis bacteriophora was enhanced in grubs infected with the milky disease bacterium, Bacillus popilliae (Bp). In concentration-response assays with the nematode, LC50 values and 95% fiducial limits were 4.0 (
PRESENCIA DEL VIRUS DE LA ENFERMEDAD DE NEWCASTLE EN AVES SILVESTRES DE UNA LAGUNA ALBUFERA CERCANA A LIMA PRESENCE OF NEWCASTLE DISEASE VIRUS IN WILD BIRDS OF A COASTAL

The present study evaluated the presence of the Newcastle Disease Virus in feces of wild birds inhabiting “El Paraiso” coastal wetland, located in the district of Huacho, Lima. Fresh fecal samples were collected from 942 wild birds of various species. The viral isolation was carried out by inoculating 10-day-old SPF embryonated eggs. Four isolates of Paramixovirus-1 (APMV-1), apparently the lentogenic type were obtained, showing that these birds were shedding the virus. This study represents the first in isolating APMV-1 in faeces from apparently healthy wild birds in Peru.
STRUCTURE OF THE CRUST ACROSS THE RED RIVER SHEAR ZONE IN NORTHERN VIETNAM FROM LINEAR ARRAY OBSERVATION

The Red River fault is the first order tectonic structure running from the southeastern margin of the Tibet plateau to the Vietnam East Sea that separates the South China block to the north and the Indochina block to the south. Hence, understanding the Red River fault structure is critical for evaluating the hypotheses of the tectonic evolution of Southeast Asia and the extrusion mechanism along the Red River fault caused by the continent-to-continent collision between the Indian and Eurasian plates. Using a 250 km long profile of 25 broadband seismic stations across the Red River fault in northern Vietnam has provided a high-resolution P receiver function section which interpreted in term of crustal architecture and composition. Results reveal distinct features of crustal structures across Red River shear zone. The Moho depth is ranging from 28 to 32 km, with an average of about 30 km. The Vp/Vs ratio is lower and stable values in the north of Red River fault but highly variable in the south, suggesting that the crust in the south of Red River fault might be effected by the interaction of micro blocks in Northern Vietnam which separated by the major faults (Ma River fault, Da River fault, Son La fault, Red River fault). The shear wave velocity profile pointed out a sharp variation of the lower crust and uppermost mantle beneath the Red River shear zone, suggesting that the Red River shear zone is a lithospheric structure.
Development of vertebrates

'BUILDING BLOCKS" To assemble Radiation Measuring Instruments foryourown special requirements Tracerlab's complete line of research equipment components is designed on the modular or "building block" principle to permit you to assemble a great variety of combinations. You get a complete system especially fitted to your own needs, at low cost. You have the advantage of exceptional flexibility, so that as your requirements change, you can add to the system or modify it with minimum time and expense. Components listed are part of a wide selection, available for immediate shipment. The Tracerlab name is your assurance of highest quality and reliability. We would be very glad to provide recommendations on the selection of proper components for your specific needs or we will furnish completed assemblies to your special requirements.
Integrin αvβ3‐targeted cancer therapy

Anti‐angiogenesis is a promising strategy for the treatment of cancer. Integrins, consisting of two noncovalently bound transmembrane α and β subunits, are an important molecular family involved in tumor angiogenesis. The blockade of integrin signaling has been demonstrated to be efficient to inhibit tumor growth, angiogenesis, and metastasis. Among all the integrins, αvβ3 seems to be the most important one during tumor angiogenesis. The inhibition of integrin αvβ3 signaling with antibodies, peptides, peptidomimetics, and other antagonists has great potential in the treatment of cancer. In addition, integrin αvβ3 is highly expressed on activated endothelial cells, new‐born vessels as well as some tumor cells, but is not present in resting endothelial cells and most normal organ systems, making it a suitable target for anti‐angiogenic therapy. In this article we will review the role of integrin αvβ3 in angiogenesis, present recent progress in the use of integrin αvβ3 antagonists and integrin‐targeted delivery systems as potential cancer therapeutics, and discuss future perspectives. Drug Dev Res 69:329–339, 2008. © 2008 Wiley‐Liss, Inc.
Web-Based Advanced Traveller Information System for Minna Metropolis, Nigeria

Advanced Traveller Information System (ATIS) is used to provide accurate, integrated and comprehensive travel and traffic information to road users. The information helps in both pre-trip and en-route decision making. This study developed a web-based ATIS for Minna metropolis in Nigeria. The information provided is from both primary and secondary sources. The developed ATIS provides information on route guidance, available intercity transport services and hotels in the metropolis. It also allows users to determine both weather and traffic flow conditions. A component of the system makes provision for electronic fare payment and booking of trips and hotel accommodation. The deployment of the ATIS is a source of static and dynamic information.