Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of discrete-time charge-domain complex bandpass filter with accurately tunable center frequency

This paper proposes a new discrete-time complex bandpass (DT CBP) filter topology in charge domain, only using switches, capacitors, input transconductors and non-overlapping 2-phase clock scheme. The proposed DT filter features better power-efficiency, reduced complexity and easier process-scaling compared to the conventional topologies. It has an inherent anti-aliasing sinc characteristic due to the windowed integration of input voltage to current/charge during each phase. The center frequency is only determined by the capacitors ratio and sampling frequency, insensitive to PVT variations. The practical non-idealities, such as finite output impedance of input gm-stage, output impedance of source follower, non-zero switch resistance, etc. are mainly analyzed in this paper and compared with the simulated results. Simulations demonstrate that the proposed DT topology is quite robust to those non-idealities.
Internet addiction and physical and psychosocial behavior problems among rural secondary school students.

The aim of this study was to determine secondary school students' levels of Internet addiction and the physical and psychosocial behavior problems they face while using the Internet. This descriptive study was conducted in three state secondary schools in a rural area in the western part of Turkey. This study's sample consisted of 549 students who agreed to participate, with the consent of their families, and who had an Internet connection at home. The data were evaluated using t-tests and variance analyses. In this study the students' score of Internet addiction was at medium level (mean addiction score 44.51 ± 17.90). There were significant differences between the students' Internet addiction scores and the presence of physical behavior problems (going to bed late, skipping meals, eating meals in front of the computer) and psychosocial behavior problems (suffering from conditions such as restlessness, anger, heart palpitations, or tremors when they could not connect to the Internet, decreased relationships with family and friends, feelings of anger, arguing with parents, and finding life boring and empty without an Internet connection).
Melanocytic Nevi in 2783 Children and Adolescents in Turkey

Abstract: This study investigated the numbers of melanocytic nevi in Turkish children and adolescents. The research was conducted on 2783 subjects (age range, 7–14 yrs) at three elementary schools in Malatya, Turkey (latitude 38°N). Numbers of melanocytic nevi per subject were counted using a standard international protocol. Comparisons were made with subjects categorized according to age, sex and skin type. The mean melanocytic nevus count was 1.07 ± 2.37. A significant positive correlation was found between nevus count and age (p < 0.001). The mean count for boys was significantly higher than that for girls (p < 0.001). Subjects with skin type II had a higher mean melanocytic nevus count than the other three groups. This is the first study related to numbers of melanocytic nevi in Turkey. The findings reveal that Turkish children and adolescents have few melanocytic nevi compared to those elsewhere in the world. In line with previous reports on other populations, analysis showed that older age, skin type II, and male sex are associated with higher melanocytic nevus counts. The results underline the importance of ethnic background in melanocytic nevus development.
Tyrosine‐like condensed derivatives as tyrosinase inhibitors

Objectives We report the pharmacological evaluation of a new series of 3‐aminocoumarins differently substituted with hydroxyl groups, which have been synthesized because they include in their structures the tyrosine fragment (tyrosine‐like compounds), with the aim of discovering structural features necessary for tyrosinase inhibitory activity.
The RAG1 Homeodomain Recruits HMG1 and HMG2 To Facilitate Recombination Signal Sequence Binding and To Enhance the Intrinsic DNA-Bending Activity of RAG1-RAG2

ABSTRACT V(D)J recombination is initiated by the specific binding of the RAG1-RAG2 (RAG1/2) complex to the heptamer-nonamer recombination signal sequences (RSS). Several steps of the V(D)J recombination reaction can be reconstituted in vitro with only RAG1/2 plus the high-mobility-group protein HMG1 or HMG2. Here we show that the RAG1 homeodomain directly interacts with both HMG boxes of HMG1 and HMG2 (HMG1,2). This interaction facilitates the binding of RAG1/2 to the RSS, mainly by promoting high-affinity binding to the nonamer motif. Using circular-permutation assays, we found that the RAG1/2 complex bends the RSS DNA between the heptamer and nonamer motifs. HMG1,2 significantly enhance the binding and bending of the 23RSS but are not essential for the formation of a bent DNA intermediate on the 12RSS. A transient increase of HMG1,2 concentration in transfected cells increases the production of the final V(D)J recombinants in vivo.
Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers

We have developed 2 new quantitative methods for measuring anti‐p53 antibodies in human serum. Using these methods we analyzed 1,392 sera from patients with various malignancies and 230 sera from individuals without malignancy. Highest prevalence of anti‐p53 antibodies was associated with ovarian and colon cancers (15%), followed by lung (8%) and breast (5%) cancers. Prevalence in other malignancies was lower (<4%). In hospitalized patients and apparently healthy individuals, prevalence was very low (<2 and 1% respectively). Extremely high antibody concentrations (> 105 U/L) were found in 5 ovarian, 2 breast, I lung and I colon cancers. Sequential analysis of 6 positive samples has shown that the p53 antibody test may have potential for patient monitoring. The p53 antibody‐positive sera from breast cancer patients were associated with tumors that were steroid hormone receptor‐negative (p < 0.002). We propose that the measurement of p53 antibodies is a relatively specific serological test for cancer, which can be performed with easily automatable and quantitative methodologies and may be further exploited for patient monitoring, prognosis, diagnosis and probably screening for selected cancers.
The Development of Shared Mental Models during Air Battlespace Collective Training using Dispersed Networked Systems

The UK Ministry of Defence (MOD) has a vision of providing Mission Training through Distributed Simulation, or UK MTDS. The paper will report the human performance results from a three year MTDS Capability Concept Demonstrator (CCD) programme presenting data to qualify the development of shared situational awareness and mental models in a networked training environment. Evidence was collected during five national and multi-national air battlespace exercises, from subjective rating scales, interviews, observational and anecdotal data. The MTDS CCD facility, based at RAF Waddington, included 8 fast-jet Tornado GR4 and Typhoon simulators, a 7-seat AWACS mission crew training system, and extensive exercise management capability (including virtual role players and Computer Generated Forces (CGF)). Data were gathered during representative daily Planning, Briefing, Execution, and Debriefing (PBED) cycles of air battlespace missions which took place at the collective, joint and multi-national levels. The MTDS CCD programme assessed the training benefit, and the optimal balance, between co-located teams and dispersed training teams (both in the UK and US). The major source of data across all sites was the application of the Mission Essential Competency (MEC) framework. Each warfighter’s expectations were recorded for a series of platform based MECs and compared to warfighter’s experiences. These data were used to assess differences between role, platform and site. To allow analysis of the robustness of the networked environment for shared cognitive processes, these were then subdivided into collective experiences, i.e. those that required interactions with other players or entities leading to collective training; and individual MEC experiences. Analysis of MEC data based on current teamwork theory allowed an assessment to be conducted of how successfully networked and dispersed training audiences were being supported in collective teamwork. The results showed that all warfighters in the UK and US received significant benefit from their participation and developed shared situational awareness enabling them to successfully meet their training objectives.
Cytotoxic Agents of the Crinane Series of Amaryllidaceae Alkaloids

In the alkaloid galanthamine, the plant family Amaryllidaceae has endowed the pharmaceutical community with a potent and selective inhibitor of the enzyme acetylcholinestersae (AChE), of prominence in the chemotherapeutic approach towards motor neuron diseases. Following on the commercial success of this prescription drug in the treatment of Alzheimer's disease, it is anticipated that other drug candidates will in future emerge from the family. In this regard, the phenanthridones, exemplified by narciclasine and pancratistatin, of the lycorine series of Amaryllidaceae alkaloids have shown much promise as remarkably potent and selective anticancer agents, with a drug target of the series destined for the clinical market within the next decade. Given these interesting biological properties and their natural abundance, plants of the Amaryllidaceae have provided a diverse and accessible platform for phytochemical-based drug discovery. The crinane series of Amaryllidaceae alkaloids are also enriched with a significant array of biological properties. As a consequence of their close structural similarity to the anticancer agents of the lycorine series, the cytotoxic potential of crinane alkaloids has been realized through structure-activity relationship (SAR) studies involving targets of both semi-synthetic and natural origin, which has identified several members as leads with promising antiproliferative profiles. As the first of its kind, this review seeks to collate such information from the past few decades in advancing the crinane group as a viable platform for anticancer drug discovery.
Design of a wideband parallel-coupled filtering antenna based on dual-frequency matching condition

In this paper, a wideband filtering antenna is designed based on the dual-frequency matching condition. Instead of matching at only one radiating frequency in the conventional filtering antenna design, an antenna element with two radiating frequencies are considered and equivalently modeled as two series-connected parallel RLC resonators, a series inductor, as well as a shunt capacitance. To obtain a wideband impedance matching, last two stages of the parallel coupled-line sections in a filter are synthesized for matching the antenna at two frequencies. Finally, a prototype of a four-pole filtering antenna is designed and fabricated. The measured results achieve a wide bandwidth of 27.8% over 2.12–2.81GHz with a flat antenna gain of 3.41 dBi over all the filtering band.
FEASTING, RITUAL PRACTICES, SOCIAL MEMORY, AND PERSISTENT PLACES: NEW INTERPRETATIONS OF SHELL MOUNDS IN SOUTHERN CALIFORNIA

Shell mounds have not been investigated as prominent ritual features in southern California, despite evidence to the contrary. The largest extant shell mound in the region is on Santa Cruz Island, measures 270 by 210 m (44,532 m² in area), is 8 m higher than the terrace it rests on, is covered with 50 house depressions, and dates to 6000–2500 B.P. In the 1920s, three cemeteries were excavated at the top of El Montón; one young woman stood out among the over 200 individuals in that she was buried with 157 stone effigies. Analysis of multiple lines of evidence, including stratigraphic profiles of features, 85 radiocarbon dates, ground penetrating radar, and mortuary data, supports my claim that the mound was a persistent place where early visitors had significant feasts, constructed dwellings, buried their dead, and performed ceremonies where select groups of infants, children, and adults were revered. These mortuary rites conveyed the symbolic power of the place and created a history of events that became part of a mythical and real past that was repeatedly visited, modified, and (re)interpreted as social relationships were reinforced. This study supports the idea that shell mounds are socially constructed landscapes, not just accumulations of refuse. A pesar de la evidencia existente, los conchales no han sido estudiados como elementos rituales prominentes en el sur de California. El conchal más grande de la región se encuentra en la isla Santa Cruz: mide 270 por 210 metros (44,532 m² en área), tiene una elevación de 8 metros por encima de la terraza donde descansa, está cubierto por 50 depresiones dejadas por viviendas y se puede fechar entre 6000 y 2500 a.P. En la década de 1920, tres conjuntos de entierros fueron excavados en la cima de El Montón; una mujer joven destacó entre los más de 200 individuos debido a que fue enterrada con 157 efigies de piedra. El análisis de múltiples líneas de evidencia, incluyendo perfiles estratigráficos, 85 fechados radiocarbónicos, información de radar de penetración terrestre y datos funerarios sustenta la interpretación que el montículo constituyó un lugar duradero donde desde épocas tempranas los visitantes celebraron significativos banquetes, construyeron viviendas, enterraron a sus muertos, y realizaron ceremonias donde fueron venerados grupos selectos de infantes, niños y adultos. Estos rituales mortuorios expresaron el poder simbólico del lugar y crearon a partir de estos eventos una historia que se convirtió en parte de un pasado mítico y real. La historia fue repetida, modificada y (re)interpretada a medida que se reforzaban las relaciones sociales. Este estudio sustenta la idea de que los conchales son paisajes socialmente construidos y no únicamente acumulaciones de desechos.
On the Advantage of Being a Dimer, a Case Study Using the DimericSerratia Nuclease and the Monomeric Nuclease fromAnabaena sp. Strain PCC 7120*

The extracellular endonucleases fromSerratia marcescens and Anabaena sp. are members of a family of nonspecific endonucleases. In contrast to the monomeric Anabaena nuclease, the Serratianuclease is a dimer of two identical subunits. To find out whether the two active sites of the Serratia nuclease function independently of each other and what the advantage of being a dimer for this enzyme might be, we produced (i) dimers in which the two subunits were cross-linked, (ii) heterodimers consisting of a wild type and an inactive mutant subunit which were also cross-linked, and (iii) monomeric variants which are unable to dimerize. The monomeric H184R variant and the cross-linked S140C variant exhibit the same activity as the wild type enzyme, while the cross-linked heterodimer with one inactive subunit shows only half of the activity of the wild type enzyme, demonstrating functional independence of the two subunits of the Serratia nuclease. On the other hand at low enzyme and substrate concentrations dimeric forms of the Serratianuclease are relatively more active than monomeric forms or the monomeric Anabaena nuclease in cleaving polynucleotides, not, however, oligonucleotides, which is correlated with the ability of dimeric forms of the Serratia nuclease to form large enzyme-substrate networks with high molecular weight DNA and to cleave polynucleotides in a processive manner. We conclude that in the natural habitat of Serratia marcescens where the supply of nutrients may become growth limiting the dimeric nuclease can fulfil its nutritive function more efficiently than a monomeric enzyme.
Effect of Tween 80 on Adriamycin Cytotoxicity in Murine P388 Leukemia

Studies on mice bearing P388 adriamycin sensitive and resistant lymphocytic leukemia were carried out to compare antitumor activity of adriamycin dissolved in Tween 80 (10 % in distilled water) with that of adriamycin dissolved in distilled water alone. The antitumor activity of adriamycin dissolved in acqueous solutions of Tween 80 was higher than that of adriamycin dissolved in distilled water against P388 leukemia sensitive to adriamycin. However, no change in the activity was observed in P388 leukemia resistant to adriamycin when the drug was administered either in acqueous solution of Tween 80 or in distilled water alone.
An analytical approach for characterizing harmonic and interharmonic currents generated by VSI-fed adjustable speed drives

Applications of solid-state converters for adjustable speed drives (ASDs) are popular in industrial systems. The ac/dc/ac conversion system, frequently used to provide ac voltages with adjustable frequency/magnitude in the ASDs, consists of a voltage source inverter (VSI) fed by a three-phase diode-bridge rectifier, which generates significant amount of line harmonic and interharmonic currents into the supply system and may cause undesired effects on other power system components. This paper presents an analytical approach for characterizing the current harmonics and interharmonics of the VSI-fed ASD injected into the supply system in steady state, where the circuit models for the rectifier, the dc link, the PWM inverter, and the ac motor are considered in the analysis. The accuracy of the results obtained by the proposed model is demonstrated by comparing with those obtained by using the time-domain simulation tool, Simulink of Matlab, and by laboratory tests. It is shown that the proposed approach is effective to characterize current harmonics and interharmonics generated by the ASD, while the solution accuracy and the computational efficiency are still maintained.
Batteryless electrostatic energy harvester and control system

This work shows how an electrostatic energy harvester based on a “doubler of electricity” can be used as energy source for low-power applications, without the need of a battery, and describes a suitable control system for it. The fact that the generator can be made to start from very small initial charge, which can be provided by electrical noise or external interference, is used to eliminate the need of a battery.
EQAS for peripheral blood morphology in Spain: a 6‐year experience

The Spanish haematology external quality assessment scheme (EQAS), established in 1984, is run by the Spanish Haematology and Haemotherapy Association (AEHH) [Quality Assurance in Health Care 3 (1991) 75] and functions to evaluate the quality and reproducibility of the assessment of diagnostic samples by clinical laboratories. The Hospital Clinic of the University of Barcelona (HCB) serves as the EQAS Coordination Centre and follows the guidelines established by the International Committee for Standardization in Haematology [Annali dell'Istituto superiore di Sanità 31 (1995) 95; International Journal of Hematology 68 (1998) 45]. During the period 2001–2006, replicates of 25 different blood films were sent to 604 EQAS participants for cell morphology evaluation. Some patient details corresponding to the samples were disclosed, such us age, sex, haemoglobin value and white blood cell count. The participants were asked to select up to four significant morphology features using a coding list, provided by the Coordination Centre, which included significant morphological alterations that appear in haematopoietic cells. For each survey, individual results were assessed against the morphological reference results (MRR) established by the Cytology Group of the AEHH (‘true’ answers). This paper describes the organization of the 6‐year‐long study and the evaluation of laboratory performance for blood smear interpretation by the Spanish haematology EQAS. Different performance levels were detected relative to the laboratory category. Laboratories providing services to hospitalized patients showed higher performances compared with laboratories providing services to nonhospitalized patients. Pathological lymphoid cells were the most difficult to identify by the participants. To improve the results in EQAS peripheral blood morphology, the development of specific cytology educational trainings is discussed.
Biopotential Readout Front-End Circuits using Frequency-Translation Filtering Techniques

III ACKNOWLEDGEMENT . IV SYMBOLS AND ABBREVIATIONS . V TABLE OF CONTENT . VIII LIST OF FIGURES . XI LIST OF TABLES . XIV CHAPTER 1: INTRODUCTION . 1 1.1 Body Area Network . 1 1.2 Biopotential Signals Characteristic . 2 1.3 Biopotential Signals Acquisition System . 3 1.4 Statement of Originality . 5 1.5 Thesis Content and Organization . 6 CHAPTER 2: INSTRUMENTATION AMPLIFIER . 7 2.
Asia1a, herramienta en línea para analizar el abandono universitario

El abandono académico es un problema que preocupa a todas las universidades. En España, las tasas de abandono oscilan entre el 30 y el 50%, según datos de la Conferencia de Rectores. Por ello, muchas instituciones estudian las causas del abandono y desarrollan programas de retención, con frecuencia dirigidos a los estudiantes de nuevo ingreso, ya que numerosos estudios confirman que el mayor porcentaje de abandono se concentra en el primer año de carrera.En este trabajo se presenta la aplicación informática en línea ASIA1a y los resultados de su aplicación, para el diagnóstico del problema del abandono de primer año, en las titulaciones de grado de la Universidad de Oviedo.El uso de ASIA1a ha permitido detectar la nota de acceso y el rendimiento académico como variables significativas e identificar las titulaciones que requieren un análisis más profundo. Como consecuencia, el grado en Derecho ha sido estudiado en detalle, con el paquete estadístico SPSS, identificando el número de créditos superados el primer año como el mejor predictor de la permanencia.Se concluye que ASIA1a favorece la toma de decisiones, por parte de la Administración Educativa, ya que permite la evaluación sistemática del indicador de calidad Tasa de permanencia y del impacto sobre dicho indicador de los programas de retención implementados. Así mismo permite identificar las variables con mayor influencia en el abandono y las titulaciones que requieren un mayor seguimiento, sentando las bases para guiar la acción orientadora y favoreciendo la eficacia de las intervenciones realizadas en este sentido.
Predicting MicroRNA-Disease Associations Using Kronecker Regularized Least Squares Based on Heterogeneous Omics Data

MicroRNAs (miRNAs) play critical roles in many biological processes. Predicting the miRNA-disease associations will aid in deciphering the underlying pathogenesis of human polygenic diseases. However, existing in silico prediction methods typically utilize a single or limited data sources for disease-related miRNA prioritization and most of the methods are biased toward known miRNA-disease associations. Due to the insufficient number of experimentally validated interactions as well as no experimentally verified negative samples, obtaining remarkable performances is still challenging for these methods. In this paper, we present a semi-supervised method of Kronecker regularized least squares for predicting the potential or missing miRNA-disease associations (KRLSM). KRLSM integrates different omics data to assist various diseases or miRNAs with sparsely known associations to make predictions, and combines the disease space and miRNA space into a whole miRNA-disease space by Kronecker product. Finally, the semi-supervised classifier of regularized least squares is adopted to identify disease-related miRNAs. The experiment results demonstrate that the proposed method outperforms the other state-of-the-art approaches. In addition, case studies of several common diseases further indicate the effectiveness of KRLSM to identify potential miRNA-disease associations.