Miracle-dz/UniFAR-FTUs huggingface dataset:
FoxM 1 is involved in the development of acute myeloid leukemia by targeting Bcl-2 expression

Background and aim: Forkhead box M1 (FoxM1) is frequently upregulated in human malignancies, including acute myeloid leukemia (AML). However, the biological function of FoxM1 in AML remains unclear. Methods: FoxM1 expression was determined by quantitative real-time PCR (qRT-PCR) and immunofluorescence analysis in AML-de novo patients, AML-complete remission (CR) patients, and AML-refractory relapse (RR) patients, alongside healthy individuals. The proliferation rate of HL60 and U937 cells transfected with FoxM1 or negative control (NC) siRNA was determined by MTT and colony formation assays, and the cellular apoptotic rate was determined by flow cytometry. The correlation between FoxM1 and B-cell leukemia/lymphoma-2 (Bcl-2) was analyzed using Pearson correlation. FoxM1 and Bcl-2 expression at mRNA and protein levels were determined by qRT-PCR and western blotting, respectively. The activity of the Bcl-2 promoter was examined using a luciferase reporter assay with FoxM1 targeting. Results: FoxM1 expression was increased in AML-de novo patients compared with that in healthy individuals and was downregulated in AML-CR patients compared with that in AML-de novo patients (all P<0.05). Silencing of FoxM1 decreased the proliferation of HL60 and U937 cells (P<0.01) and increased the apoptotic rate (P<0.01). Additionally, Bcl-2 mRNA level was significantly increased (P<0.01) in AML-de novo patients and showed a significant positive correlation with FoxM1 expression (r=0.7458, P<0.001). Luciferase activity of the Bcl-2 promotor was suppressed following FoxM1 binding (P<0.01). Conclusion: Silencing of FoxM1 inhibits proliferation and promotes apoptosis of AML cells. FoxM1 is involved in the development of AML by regulating Bcl-2 expression.
Gender inequality in the labour market outcomes in times of austerity Final report

Responding to high fiscal deficit in the country, Serbian Government introduced a set of austerity measures at the beginning of 2015, including a cut in the wages and workforce downsizing in the public sector. Recent literature suggested that female wages and employment are more likely to be hit by the austerity measures as women form a majority of public sector employees, although existing evidence is largely descriptive. Aim of this paper is to estimate whether the wage cut had different effects on female and male employment and wages by using 2014/2015 panel data from Labour Force Survey. The results show that the wage cut has increased the likelihood of younger and older female employees to move to unemployment and inactivity, respectively, while for men we do not observe such effects. On the other hand, femaledominated subsectors within the public sector were hit more by the wage cut due to their higher compliance with the wage cut compared to the subsector of public enterprises where man are the majority of the workforce. JEL: J16, J21, J31, J45, H61.
Optimization of Unsupervised Classification by Evolutionary Strategies

The kmeans algorithm is an unsupervised classification algorithm. This algorithm however, suffers from two difficulties which are the initialization phase and the local optimums. We present in this paper some improvements to this algorithm based on the evolutionary strategies in order to get around these two difficulties. We have designed a new evolutionist kmeans algorithm. We have proposed a new mutation operator in order for the algorithm to avoid local solutions and to converge to the global solution for a low computational time. This approach is validated on some simulation examples. The experimental results obtained confirm the rapidity of convergence and the good performances of the proposed algorithm.
Research on Adaptive Control Method of Cantilever Beam Vibration Suppression

A method of adaptive control of vibration suppression by establishing the cantilever Bernoulli-Euler beam model is proposed.Firstly, based on the study of the model reference adaptive theory, the Lyapunov stability model reference adaptive control method is established to suppress the cantilever vibration. The transverse vibration differential equations of the cantilever beam system and the transverse vibration differential equations of the modal coordinates are established and simulated under the ANSYS Workbench software environment to obtain the optimal position of the vibration sensor/brake. According to the differential equation of transverse vibration of the modal coordinates of the system model, the state space equation and transfer function of the system corresponding to the system are obtained, which are mathematically transformed into difference equation and used as the mathematical model of parameter identification. On this basis, band-pass filter and recursive least squares method are combined to identify the natural frequency of sensor signal. Finally, the adaptive controller for vibration suppression of cantilever beam is simulated by using MATLAB software. The results show that the control method can achieve better suppression effect.
MEASUREMENT AND PREDICTION OF FUEL OXYGENATES MIXTURES EXCESS THERMOPHYSICAL PROPERTIES - A REVIEW

Excess thermophysical properties are important in understanding the molecular interaction between unlike molecules. The excess properties data are very important for process design and separation, especially in chemical industry. The excess thermophysical properties reviewed are excess molar volume, excess molar enthalpy and viscosity. In this review, particular interest is taken on binary mixtures of fuel oxygenates which are methyl tert-butyl ether (MTBE), ethyl tert-butyl ether (ETBE), tert-amyl methyl ether (TAME) with lower alcohols. This review will enable researchers to know what are the mixtures studied and where future work is required.
Production of tumor necrosis factor-á is increased in urinary tract infections

BACKGROUND Urinary tract infection (UTI) is a common source of bacteriemia. The most common cause of UTI is Escherichia coli (E. coli). Tumor Necrosis Factor (TNF)-a gene polymorphism has been reported to be responsible for an excessive production of TNF-a and eventual disruption of pro-inflammatory cytokine regulation. The aim of this study was to compare TNF-a serum levels and TNF-a allele polymorphisms in patients with UTI due to E.coli and in non- UTI controls. METHODS A cross-sectional study was conducted at Dr. Kariadi Central Hospital and the Center for Biomedical Research, Faculty of Medicine, Diponegoro University, Semarang. In 68 patients with UTI the TNF-a serum levels were determined by means of ELISA and compared to those of non-UTI controls (n=55). TNFa- 308G>A gene polymorphism was analyzed by polymerase chain reaction restriction fragment length using the NcoI enzyme. Fragments were visualized on polyacrylamide gel with silver staining. RESULTS TNF-a serum level in patients with UTI had a median of 8.9 pg/mL, which was significantly higher than the median of 3.7 pg/mL in the control group (pA gene polymorphisms found in the patient group were G/G=61 (90%), G/A=7(10%) and A/A=0, while in the control group were G/G=48 (87%), G/A=7 (13%) and A/A =0. There was no significant differences (p=0.578) in gene polymorphisms between the two groups. CONCLUSIONS TNF-a serum levels in patients with UTI due to E. coli were significantly higher than in non-UTI controls, but for the TNF-a-380 gene polymorphisms no significant difference was found between the two groups. There are presumably more important factors than host genotype that influence UTI pathogenesis.
Building Analogy Systems : Some Lessons Learned

Analogy is a powerful method of reasoning and learning, but it does not stand alone. Analogical reasoning, we have found, works best when tightly integrated with other forms of reasoning and learning. This paper summarizes some lessons learned in creating reasoning and learning systems that incorporate analogy for a variety of tasks. The key lessons are: (1) a general-purpose, expressive ontology is very useful, (2) reified contexts for reasoning, called microtheories, provide a powerful way to organize knowledge, including cases, (3) the requirements of analogical retrieval and generalization provide interesting constraints on knowledge base design. These lessons are illustrated with examples from prior cognitive systems projects, and three open questions are discussed.
THE ANATOMY OF EFFIGIA OKEEFFEAE (ARCHOSAURIA, SUCHIA), THEROPOD-LIKE CONVERGENCE, AND THE DISTRIBUTION OF RELATED TAXA

Abstract Effigia okeeffeae is named based on a well-preserved nearly complete skeleton from the Upper Triassic (? Rhaetian) “siltstone member” at Ghost Ranch, northern New Mexico. The skull is described and compared to other suchian and basal archosaurs. The maxilla and premaxilla are edentulous, and a rhamphotheca was possibly present in life. Effigia conclusively indicates that the skull of Shuvosaurus and the postcrania of “Chatterjeea” belong to the same taxon. Furthermore, the close relationship between Shuvosaurus and Effigia indicates that both taxa are nested within the suchian clade and not within Ornithomimisauria. However, the similarity in features in the skull and postcrania of Effigia and ornithomimids suggests extreme convergence occurred between the two clades. A clade containing Arizonasaurus, Bromsgroveia, Poposaurus, Sillosuchus, Shuvosaurus, and Effigia is suggested based solely on shared derived character states. Additionally, a clade (Clade Y) containing Sillosuchus, Shuvosaurus, and Effigia is well supported by further derived character states. The distribution and temporal pattern of members of Group Y suggest that members of Group Y are present in the early Middle Triassic through the Latest Triassic of North America, and one member of the clade, Sillosuchus, was present in South America.
Promoting Government Controlled Vocabularies for the Semantic Web : the EUROVOC Thesaurus and the CPV Product Classification System

The aim of the paper is to promote government controlled vocabularies for the Semantic Web in the context of the European Union. We will propose SKOS as the RDF/OWL common data model and an enclosed conversion method for the knowledge organization systems available in RAMON, the Eurostat Metadata Server. The study cases of this paper will be the Eurovoc Thesaurus and the Common Procurement Vocabulary, a product classification system.
Hepatitis C Incidence and Spontaneous Viral Clearance ina Cohort of Human Immunodeficiency Virus and Hepatitis B Virus Negative Drug Users

Estimating HCV incidence and viral clearance in other than young, White, injection drug users (IDUs), negative for HBV and HIV has not been undertaken. We enrolled 1,260 mostly African American injecting and non-injecting drug users negative for HIV and HBV prospectively from urban areas in Houston, TX, from 2005-2009, to determine HCV incidence and spontaneous viral clearance. Socio demographic and high risk behavioral data and blood samples were collected every 6 months for two years. Serum was tested for antibodies to HCV by enzyme immunoassay (EIA), and confirmed for HCV RNA by polymerase chain reaction (PCR). Kaplan-Meier failure curves and Cox proportional hazard regression analyses were performed to identify factors for HCV incidence. A follow-up HCV RNA PCR test was used to determine viral clearance in HCV incident cases. We followed 840 anti-HCV negative participants resulting in 19 HCV seroconversions per 1436.67 person years for an HCV incidence of 13.2/1000 PY (95% Confidence Interval [CI], 8.420.7). IDU’s risk of contracting HCV compared to non-injecting drug users (62.5 per 1000PY, 95% CI, 33.6-116.2, vs. 7.1 per 1000PY, 95% CI 3.7-13.6) was significantly higher. White/Hispanic race, injecting drugs at least daily, and being 40 years of age or older were significant risk factors for HCV seroconversion. Spontaneous viral clearance was observed in 42% of HCV incident cases. HCV incidence remains high among HB vaccinated drug users. Daily injecting drug use is a predictor for new HCV infection. An HCV vaccine is urgently needed, especially in high risk populations.
A Corpus-Based Analysis of N-Grams in English Texts Written by Chinese Learners

Recent linguistic studies have shown that proper use of multi-word expressions, or n-grams, is quite essential in foreign language acquisition. By contrast of the different types of n-grams from native corpus and Chinese learners’ corpus, the present article is devoted to discussing distinctive features of n-grams use in English texts written by Chinese learners. Generally, Chinese learners have not developed a strong awareness of distinguishing written style from spoken style of English texts. Also they tend to produce various n-grams which reflect the Chinese social development. Besides, they usually overuse n-grams of “a personal pronoun + a modal or mental verb” to stress human subjective ideas, attitudes or feelings toward the objective world. In addition, they can not output n-grams about quantity in a native-like way. The article also explores the causes of those peculiar features above mentioned from linguistic, social, cultural and cognitive perspectives. The study may not only helps readers get a better understanding about the n-gram features involved in Chinese learners’ English texts, but also brings some practical implications to EFL teaching.
THE IMPACT OF ARTIFICIAL SELECTION ON RUNS OF HOMOZYGOSITY IN SLOVAK SPOTTED AND PINZGAU CATTLE

The aim of this study was to analyse the distribution of runs of homozygosity (ROH) across the genomes of Slovak Spotted and Slovak Pinzgau cattle and to describe the autozygosity islands resulting from the selective breeding for traits of interest during the development of these breeds. The genome-wide data for a total of 236 animals were obtained by using two platforms: Illumina BovineSNP50v2 BeadChip and ICBF International Dairy and Beef v3. After quality control, the database of genotyping data consisted of 39,261 common SNPs across both breeds that covered overall length 2,497,077 kb of the genome with average distance between adjacent SNPs 63.67 kb. The ROH segments were defined as genomic regions with 15 or more consecutive homozygous calls with maximum gap between SNPs of 1 Mb and minimum density of one SNPs on every 100 kb. The distribution of ROH was analysed for five length categories (> 1 Mb, > 2 Mb, > 4 Mb, > 8 Mb, and > 16 Mb). The results showed that the ROH segments were present across the genome of all animals, with the average number of 54.59 ± 18.58 segments and the average length of 130.33 ± 58.40 Mb. The short segments (> 1 Mb) were the most frequent through the genomes and accounted for 70.26 % (Slovak Spotted) or 65.99 % (Slovak Pinzgau) of all segments detected. Thus, our results indicated that on average 6.11 % (Slovak Spotted) and 4.72 % (Slovak Pinzgau) of the genomes are autozygous. Moreover, the proportion of ROH > 16 Mb revealed that on average 0.45 % of the Slovak Spotted and 0.88 % of the Slovak Pinzgau genomes could be affected by recent inbreeding. Despite the fact that the distribution of ROH differentiated between breeds, the major fraction of chromosome residing in ROH was observed on BTA6 (13.49 % resp. 14.26 % of autosomal length in ROH). In this region we identified various QTLs and genes responsible for milk production (CSN1S1, CSN1S2, CSN2, CSN3), and coat colour patterns (KIT). Generally, our results confirmed that the regions displaying autozygosity in Slovak Spotted and Slovak Pinzgau cattle are linked mostly to milk production and muscle development thus ensuring selection for dual-purpose performance.
THE OPTIMAL TEMPERATURE FOR THE GROWTH OF BLUEBERRY ( VACCINIUM CORYMBOSUM L . )

Blueberry (Vaccinium corymbosum L.), a perennial evergreen or deciduous shrub, has recently been introduced into Southern China, where the subtropical climate is hot and humid in summer. Identifying the optimal growth temperatures and understanding the mechanisms of thermal stress on blueberry are not only critical to determining suitably growing areas in Southern China, but also significantly important for selecting and breeding new heat tolerance blueberry cultivars for adapting to subtropical climates. In this study, we examined the optimal temperature for the growth of six blueberry cultivars (‘Bluecrop’, ‘Duke’, ‘Brigitta’, ‘Gulfcoast’, ‘O’Neal’, and ‘Blue Ridge’) with four growth chambers where the temperatures were controlled at 25, 30, 35, and 40°C, respectively. We found that initial increase in temperature dramatically enhanced the growth of four cultivars (‘Bluecrop’, ‘Duke’, ‘Brigitta’, and ‘Blue ridge’) through the warming effect, whereas this warming effect was substantially compromised with further increase in growth temperature, demonstrating an optimal temperature of 32.6, 30.4, 31.8, and 29.0°C for the four cultivars respectively. By contrast, the aboveground, belowground, and total biomass of ‘Gulfcoast’ and ‘O’Neal’ were linearly declined with growth temperatures, indicating that elevating temperature above 25°C had negative effects on blueberry growth. Meanwhile, we also found that the leaf photosynthesis, stomatal conductance, and transpiration of the six blueberry cultivars shared similar trends as plant growth in response to temperatures, suggested that leaf biochemical and photochemical processes affecting the optimal growth temperature of blueberry plants. Moreover, the temperature effects on blueberry growth was also attributed to the changes in the leaf number, leaf length and width, leaf biomass, as well as the leaf stomatal traits including density, openness, and spatial distribution pattern of stomata. In addition, high temperatures exceeding the optima also affected chloroplast structures through damaging grana lamella and stromal lamella as well as breaking chloroplast envelope. Our results suggested that the optimal growth temperature of blueberry was highly dependent on cultivars. Therefore, the optimal temperature found in this study can be used as an indicator in selecting and breeding new blueberry strains in adapting to high temperatures in subtropical China where the market demands for blueberry products have been skyrocketing.
DESIGN AND EVALUATION OF PHYSICALLY INSPIRED MODELS OF SOUND EFFECTS IN COMPUTER GAMES

A simple audio only game was designed in order to test the possibilities of different interactive sound synthesis techniques simulating aerodynamic sword-like sounds. The Wii remote was used as the controller for generating the sound and this device was connected to the Max/MSP sound synthesis engine. In order to gain a user centered perspective on the potential of the diverse synthesis techniques, in terms of sound quality, interactivity and entertainment value, several techniques to synthesize real time interactive sword-like sounds were implemented. In this test a sample based model was compared to physically inspired modal synthesis, purely perceptually modeled subtractive synthesis and granular synthesis.
Benthic community mapping in the northern Dreki area, Iceland

The deep Arctic seafloor supports a wide diversity of benthic megafauna that provide important ecosystem services. However, deep-sea Arctic environments are increasingly under threat due to climate change and ocean acidification as well as the ongoing expansion of human activities such as fishing, shipping, and hydrocarbon production into deeper and higher-latitude waters. There is thus a growing need for baseline information on megafauna community composition and distribution, without which assessment of impacts is virtually impossible. This study reviewed the available information on deep-sea megafauna communities in the Greenland-Iceland-Norwegian (GIN) Seas. An in-depth review of 12 studies documented a diverse array of benthic communities and revealed large regional variations in the quantity and quality of information. No information was available for the northern Dreki area in the Icelandic EEZ despite interest in hydrocarbon exploration in this area. This study modelled the distribution of communities at a 10,500 km study site located within the northern Dreki area. Acoustic and benthic surveys were carried out at this site in 2008. The benthic data were analysed using multivariate methods, resulting in the identification of five megafauna communities. Random forest was used to model the relationship between communities and variables derived from the acoustic survey data, including depth and backscatter, which enabled the generation of a full-coverage map of predicted community distribution. While this map indicates that the impacts of hydrocarbon operations could greatly alter community structure in the northern Dreki area, further studies using more comprehensive datasets are required to confirm these findings.
Deliverable-2 : Nanosystems for Healthcare and Environmental Monitoring Report on the activities for the period : September 2009 – Feb 2010 : Faculty / Staff Involved :

Report on the activities for the period: September 2009 – Feb 2010: Faculty/Staff Involved: S. Mukherji, V. Ramgopal Rao, A. Q. Contractor, Anilkumar, D. K. Sharma, P. Gandhi, Suparna M. , T.Kundu, Nitin Kale, Sheetal Patil Assessment of Protocols for antibody immobilization on Au surface in SPR sensor: Although the results of sucrose experiments have been consistently good in our setup, the antigen-antibody experiments did not produce consistent and reproducible results. In order to find out the reason behind this, characterization of the surface was performed at various stages of the preparation process.
Clinical, Radiological and Surgical Pitfalls in Fibular Tumors Fibula Yerleşimli Tümörlerde Klinik, Radyolojik ve Cerrahi Tuzaklar

Introduction: Although fibula based tumors are less common, they are important since a great number of them are local aggressive and malign. The purpose of this study is to evaluate the patients with fibula based tumors and to focus on pitfalls in diagnosis and treatment. Methods: 36 patients who had been diagnosed with and treated for tumor involving fibula between May 2007 and June 2015 were examined retrospectively. The patients’ ages, genders and localizations were specified. Tumor’s radiologic features and histological type, type of resection and complications were analyzed. Results: 20 of the patients were women, while 16 were men and the average age of the patients was 31.5 (6-74) years of age. Tumor was found in fibula 1/3 proximal zone of 26 patients, in fibula 1/3 middle zone of 6 patients and in fibula 1/3 distal zone of 4 patients. Histological, 23 were benign, 9 were malign and 4 were metastatic tumors. Intralesional curettage was performed on 19 patients, wide resection was performed on 15 patients and amputation was performed on 2. Discussion and Conclusion: Fibula involves some surgical difficulties because of its contribution to knee joint and ankle stability and its close adjacency to neurovascular structures in proximal. Radiologically, tumor borders and how much bone can be sacrificed should be planned well. With a good planning and a careful surgical treatment, tumor can be removed without complications.