Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of acute toxicity of Karate and its sub-lethal effects on protein and acetylcholinestrase activity in Cyprinus carpio.

Karate is a locally used pesticide, has lambda cyhalothrin (λ-Cyhalothrin) as an active ingredient. To determine the acute toxicity, fry of Cyprinus carpio were exposed to 0.00, 0.08, 0.16, 0.2, 0.24, 0.32 and 0.4 μL L of Karate for 96 h in a static bioassay. The 96 h LC50value was determined by using Arithmetic method and found to be 0.160 μL L . Fry of C. carpio were exposed to 10% (0.16 μL L) and 20% (0.032 μL L) lethal concentration of pesticide and observed the effects on total protein content and acetylcholinestrase (AChE) activity in brain, liver and muscle tissues. The total protein content and AChE activity in different tissues of fish decreased in concentration dependent manner and showed tissue specific pattern. The maximum reduction of AChE activity was observed in brain followed by muscle and liver tissues while liver showed higher decline in protein content as compared to muscle and brain tissues. The minimum reduction of protein content in response to Karate was observed in brain tissues. The study clearly indicated the toxicity of Karate to fish and suggest the prevention of indiscriminate use of this pesticide. © 2014 Friends Science Publishers
DENSITY JUMPS ACROSS PHASE TRANSITIONS IN SOFT-MATTER SYSTEMS

We investigate the magnitude of density jumps across phase transitions in soft-matter systems composed of macromolecular particles, like star polymers or colloidal suspensions. The standard route to predict phase transformations is to start from an effective interaction potential between these macroparticles and map the phase diagram onto that of the corresponding effective one-component system. Using density-functional perturbation theory, we demonstrate that this procedure leads to wrong density jumps if the number of microscopic degrees of freedom is coupled to the number of macroparticles. In particular, the microscopic degrees of freedom can drive a macroparticle phase transition to be isochoric, i.e., to occur without any jump in the macroparticle density.
Nodeless superconductivity in the type-II Dirac semimetal 
PdTe2
: London penetration depth and pairing-symmetry analysis

Superconducting gap structure was probed in type-II Dirac semimetal PdTe$_2$ by measuring the London penetration depth using tunnel diode resonator technique. At low temperatures, the data for two samples are well described by weak coupling exponential fit yielding $\lambda(T=0)=230$~nm as the only fit parameter at a fixed $\Delta(0)/T_c\approx 1.76$, and the calculated superfluid density is consistent with a fully gapped superconducting state characterized by a single gap scale. Electrical resistivity measurements for in-plane and inter-plane current directions find very low and nearly temperature-independent normal- state anisotropy. The temperature dependence of resistivity is typical for conventional phonon scattering in metals. We compare these experimental results with expectations from a detailed theoretical symmetry analysis and reduce the number of possible superconducting pairing states in PdTe$_2$ to only three nodeless candidates: a regular, topologically trivial, $s$-wave pairing, and two distinct odd-parity triplet states that both can be topologically non-trivial depending on the microscopic interactions driving the superconducting instability.
Flaxseed Can Reduce Hypoxia-Induced Damages in Rat Testes

Background Hypoxia causes detrimental effects on the structure and function of tissues through increased production of reactive oxygen species that are generated during the re-oxygenation phase of intermittent and continuous hypobaric hypoxia. This study was carried out to evaluate the effects of flaxseed (Fx) in reducing the incidence of hypoxia in rat testes. Materials and Methods In this experimental study, 24 adult Wistar rats were randomly divided into four groups: i. Control group (Co) that received normal levels of oxygen and food, ii. Sham group (Sh) that were placed in hypoxia chamber but received normal oxygen and food, iii. Hypoxia induction group (Hx) that were placed in hypoxia chamber and treated with normal food, iv. Hypoxia induction group (Hx+Fx) that were placed in hypoxia chamber and treated with 10% flaxseed food. Both the Hx and Hx+Fx groups were kept in a hypoxic chamber for 30 days; during this period rats were exposed to reduced pressure (oxygen 8% and nitrogen 92%) for 4 hours/day. Then, all animal were sacrificed and their testes were removed. Malondialdehyde (MDA) and total antioxidant capacity (TAC) levels were evaluated in the testis tissue. Tubular damages were examined using histological studies. Blood samples and sperm were collected to assess IL-18 level and measure sperms parameters, respectively. All data were analyzed using SPPSS-22 software. One way-ANOVA or Kruskal-Wallis tests were performed for statistical analysis. Results A significant difference was recorded in the testicular mass/body weight ratio in Hx and Hx+Fx groups in comparison to the control (P=0.003 and 0.027, respectively) and Sh (P=0.001 and 0.009, respectively) groups. The sperm count and motility in Hx+Fx group were significantly different from those of the Hx group (P=0.0001 and 0.028, respectively) . Also sperm viability (P=0.0001) and abnormality (P=0.0001) in Hx+Fx group were significantly different from Hx group. Conclusion This study therefore suggests that the oral administration of flaxseed can be useful for prevention from the detrimental effects of hypoxia on rat testes structure and sperm parameters.
Femtosecond-LASIK outcomes using the VisuMax®-MEL® 80 platform for mixed astigmatism refractive surgery.

AIM To evaluate the predictability, efficacy and safety of Femtosecond-laser-assisted in situ keratomileusis (LASIK) procedure for mixed astigmatism. PATIENTS, MATERIALS AND METHODS We prospectively evaluated for 12 months 74 eyes (52 patients) with mixed astigmatism that underwent Femtosecond-LASIK treatment. The preoperative mean refractive sphere value was +1.879±1.313 diopters (D) and the mean refractive cylinder value was -4.169±1.091 D. The anterior corneal flap was cut using the VisuMax® femtosecond laser and then the stromal ablation was done using the MEL® 80 excimer laser. RESULTS Mean age was 30.22±6.421 years with 61.53% female patients. Postoperative spherical equivalent at 12 months was within ±0.5D of emmetropia in 75.8% of eyes and within ±1D in 97.3% of eyes. Postoperative uncorrected distance visual acuity was equivalent to or better than the preoperative corrected distance visual acuity in 91.9% of eyes. Compared to the preoperative corrected distance visual acuity (CDVA), 8.1% of eyes gained one line, 2.7% gained two lines and 2.7% gained three lines of visual acuity. CONCLUSIONS Femtosecond-LASIK using the VisuMax®-MEL® 80 platform appears to have safe, effective and predictable results in mixed astigmatic eyes. The results are impressive for high refractive error treatment and for improvement of both uncorrected and corrected distance visual acuity.
Detection and Analysis Cerber Ransomware Using Network Forensics Behavior Based

Kaspersky and other information security ﬁrms mentioned 2016 as the year of Ransomware. The impact of attacks has allowed ﬁnancial damage on the business or individual. The FBI estimates that losses incurred in 2016 will top US$ 3 billion. Meanwhile, cyber criminals use malware: Trojans, Spyware, and Keyloggers, all of which require long tremendous eﬀort to transfer beneﬁts into their bank accounts; while Ransomware makes the process automatic and easy by using a business model of Ran-somware as a Service (RaaS). Therefore, Ransomware are made more sophisticated and more eﬀective as to avoid detection and analysis. In this paper, we present a new insight into detection by analyzing Cerber Ransomware using Network-Forensic-Behavioral-Based. This paper is aimed to reconstruct the attack of timestamp, to identify the infected host and malware, to compromise websites involved in the chain of infection, to ﬁnd campaigns scripts, and to exploit kits and payload Ransomware.
3D Simulator with Hardware-in-the-Loop capability for the Micromouse Competition

Robotics competitions are a way to challenge researchers, roboticists and enthusiastic to address robot applications. One of the well-known international competition is the Micromouse where the fastest mobile robot to solve a maze is the winner. There are several topics addressed in this competition such as robot prototyping, control, electronics, path planning, optimization, among others while keeping the size of the robot as small as possible. A simulation can be used to speed-up the development and testing algorithms but faces the gap between a simulation and reality, specially in the dynamics behaviour. There are some simulation environments that allow to simulate the Micromouse competition, but in this paper, an Hardware-in-the-loop simulator tool is presented where the simulated robot is controlled by the same microcontroller used by the robot. By this way, the developed algorithms are tested and validated with the limitations and constraints presented in the real hardware, such as memory and processing capabilities. The robot dynamics, the slippage of the wheels, the friction and the 3D visualization are present in the simulator. The presented results show that the same code and hardware controlling the simulated and the real robot identically.
Organic–inorganic hybrid CH3NH3PbI3 perovskite materials as channels in thin-film field-effect transistors

Organic–inorganic hybrid perovskite materials promise both the superior carrier mobility of inorganic semiconductors and the processability of organic materials, which make organic–inorganic hybrid perovskite materials good substitutes in all the applications put forth for organic materials and extend their application to higher speed devices than is presently possible with either a-Si or organic semiconductors. Recent reports have shown high carrier mobility and long electron–hole diffusion lengths of organic–inorganic hybrid perovskite materials. We have demonstrated a thin-film field-effect transistor with an organic–inorganic hybrid CH3NH3PbI3 material as the semiconducting channel based on these advantages via a low-temperature vapor-assisted solution process. The obvious electrical field effect is obtained in organic–inorganic hybrid CH3NH3PbI3 perovskite TFTs with a field-effect mobility of 396.2 cm2 V−1 s−1, current modulation greater than 104, sub-threshold current of 0.4035 V per decade and threshold voltage of −3.501 V.
Oxygen availability and skeletal muscle oxidative capacity in patients with peripheral artery disease: implications from in vivo and in vitro assessments.

Evidence suggests that the peak skeletal muscle mitochondrial ATP synthesis rate ( Vmax) in patients with peripheral artery disease (PAD) may be attenuated due to disease-related impairments in O2 supply. However, in vitro assessments suggest intrinsic deficits in mitochondrial respiration despite ample O2 availability. To address this conundrum, Doppler ultrasound, near-infrared spectroscopy, phosphorus magnetic resonance spectroscopy, and high-resolution respirometry were combined to assess convective O2 delivery, tissue oxygenation, Vmax, and skeletal muscle mitochondrial capacity (complex I + II, state 3 respiration), respectively, in the gastrocnemius muscle of 10 patients with early stage PAD and 11 physical activity-matched healthy control (HC) subjects. All participants were studied in free-flow control conditions (FF) and with reactive hyperemia (RH) induced by a period of brief ischemia during the last 30 s of submaximal plantar flexion exercise. Patients with PAD repeated the FF and RH trials under hyperoxic conditions (FF + 100% O2 and RH + 100% O2). Compared with HC subjects, patients with PAD exhibited attenuated O2 delivery at the same absolute work rate and attenuated tissue reoxygenation and Vmax after relative intensity-matched exercise. Compared with the FF condition, only RH + 100% O2 significantly increased convective O2 delivery (~44%), tissue reoxygenation (~54%), and Vmax (~60%) in patients with PAD ( P < 0.05), such that Vmax was now not different from HC subjects. Furthermore, there was no evidence of an intrinsic mitochondrial deficit in PAD, as assessed in vitro with adequate O2. Thus, in combination, this comprehensive in vivo and in vitro investigation implicates O2 supply as the predominant factor limiting mitochondrial oxidative capacity in early stage PAD. NEW & NOTEWORTHY Currently, there is little accord as to the role of O2 availability and mitochondrial function in the skeletal muscle dysfunction associated with peripheral artery disease. This is the first study to comprehensively use both in vivo and in vitro approaches to document that the skeletal muscle dysfunction associated with early stage peripheral artery disease is predominantly a consequence of limited O2 supply and not the impact of an intrinsic mitochondrial defect in this pathology.
Targeting the messengers: Serine/threonine protein kinases as potential targets for antimycobacterial drug development

The emergence of increasingly drug‐resistant Mycobacterium tuberculosis strains has become a crucial public health concern. In order to effectively treat tuberculosis, it is imperative to find newer drug targets, which are important for the in vivo bacterial survival and persistence. Phosphorylation based signaling cascades modulated by eukaryotic‐like serine/threonine protein kinases and phosphatase in M. tuberculosis, transduce extracellular stimuli to a cellular response ensuing pathogen's growth, persistence and pathogenesis. Of the 11 STPKs that M. tuberculosis genome encodes, three kinases, namely PknA, PknB and PknG and the sole serine/threonine phosphatase PstP are crucial for the intracellular survival of the bacteria. PknA and PknB regulates cell growth, cell wall synthesis and morphological changes during bacterial cell division; while PknG modulates metabolic changes in response to stress and aids in bacterial survival during latency like conditions. PstP functions to dephosphorylate STPKs and their substrates and hence is important at nearly all stages of infection. Here, we review the current knowledge on PstP, PknA, PknB and PknG based on the genetic, biochemical, and functional studies in M. tuberculosis physiopathology. We further explore the potential of these molecules as targets for therapeutic intervention and discuss the advancement made in the development of inhibitors against these targets. © 2018 IUBMB Life, 70(9):889–904, 2018
An Update of Oral Health Curricula in US Family Medicine Residency Programs.

BACKGROUND AND OBJECTIVES National initiatives have encouraged oral health training for family physicians and other nondental providers for almost 2 decades. Our national survey assesses progress of family medicine residency programs on this important health topic since our last survey in 2011. METHODS Family medicine residency program directors (PDs) completed an online survey covering various themes including number of hours of oral health (OH) teaching, topics covered, barriers, evaluation, positive influences, and program demographics. RESULTS Compared to 2011, more PDs feel OH should be addressed by physicians (86% in 2017 vs 79% in 2011), yet fewer programs are teaching OH (81% vs 96%) with fewer hours overall (31% vs 45% with 4 or more hours). Satisfaction with the competence of graduating residents in OH significantly decreased (17% in 2017 vs 32% in 2011). Program directors who report graduates being well prepared to answer board questions on oral health topics are more likely to have an oral health champion (P<0.001) and report satisfaction with the graduates' level of oral health competency (P<0.001). Programs with an oral health champion, or having a relationship with a state or national oral health coalition, or having routine teaching from a dental professional are significantly more likely to have more hours of oral health curriculum (P<0.001). CONCLUSIONS Family medicine PDs are more aware of the importance of oral health, yet less oral health is being taught in residency programs. Developing more faculty oral health champions and connecting programs to dental faculty and coalitions may help reduce this educational void.
The Role of Emotional Intelligence in Engagement in Nurses

Aware that engagement in the healthcare field needs high levels of emotional intelligence, we began this study to determine relationship between engagement and emotional intelligence in nurses. The objective of this study was to determine the explanatory value of the components of emotional intelligence for engagement in a sample of nurses. The final study sample was made up of 2126 working nursing professionals. Data was obtained by distributing, an ad hoc questionnaire was used to collect sociodemographic information, and to collect professional and employment information, the Utrecht Work Engagement Scale and the Reduced Emotional Intelligence Inventory for Adults were used. The results showed that nurses with higher levels of emotional intelligence also scored more highly in engagement, with the interpersonal factor being the greatest predictor of engagement. This study has significant practical implications for the creation of intervention programs and activities to improve the performance of nurses in the workplace.
Autism throughout genetics: Perusal of the implication of ion channels

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental psychiatric disorders characterized by deficits in social interactions, interpersonal communication, repetitive and stereotyped behaviors and may be associated with intellectual disabilities. The description of ASD as a synaptopathology highlights the importance of the synapse and the implication of ion channels in the etiology of these disorders.
Comparison of the peri-and postoperative parameters between artery-only and artery-vein clamping techniques in partial nephrectomy : a systematic review and meta-analysis

Renal artery-only (AO) and renal artery-vein (AV) clamping are known as the conventional hilar clamping techniques in partial nephrectomy (PN), but there is a paucity of data comprehensively comparing the two techniques. This meta-analysis aimed to compare the periand postoperative outcomes between AO and AV clamping techniques in PN. Electronic databases including Pubmed, Embase, Web of Science, and the Cochrane Library were searched. Randomized controlled trials (RCTs) and observational comparative studies, providing data of patient baseline variables, and periand postoperative outcomes of the two clamping techniques were included. Two reviewers independently screened literature, extracted data, and appraised the quality of the included studies. A meta-analysis was performed for the outcomes of interest. A total of five studies and 549 patients were included. The meta-analysis showed that AV clamping PN had a shorter operative time (P = 0.003) when compared with AO clamping PN. No significant differences were detected between the two groups in estimated blood loss (EBL) (P = 0.15), blood transfusion rate (P = 0.71), urine leakage rate (P = 0.36), postoperative complication rate (P = 1.00), and positive margin rate (P = 0.81). A descriptive analysis showed that AV clamping could get comparable results for renal function after surgery when compared with AO clamping technique. In conclusion, this meta-analysis shows that AV clamping is comparable with AO clamping technique with regard to periand postoperative outcomes. Considering the inherent limitations of the included studies, the result should be carefully applied based on appropriate patient selection. Thus well-designed randomized future clinical trials are needed.
Poly ( lactide-co-glycolide ) Microspheres for MRI-Monitored Delivery of Sorafenib Locally to Liver Tumors

Summary Sorafenib is a multikinase inhibitor chemotherapeutic effective in treating hepatocellular carcinoma (HCC). However, the oral tablet formulation is associated with severe side effects, resulting in poor patient tolerance. To address such issues, this study works to re-formulate sorafenib as part of an embolic microsphere platform to enable local delivery of sorafenib to the liver tumors via catheters placed in tumor-feeding arteries.
Modeling and Analysis of Human Memory Load in Multitasking Scenarios: Late-Breaking Results

This paper presents on-going work developing a formal framework for the model-based analysis of human-machine interaction in multiple critical systems. The framework builds on classical results from applied psychology on selective attention and working memory. The framework is intended for developers of interactive critical systems to identify plausible human multitasking strategies that are likely to be adopted by operators when using multiple interactive systems at the same time, and to estimate the memory load necessary to complete concurrent tasks. This type of analysis is especially useful at the early stages of system design, to better understand the effort necessary to operate the system when an implementation or a prototype of the system is unavailable. The analysis can also be used retrospectively, to analyse already implemented systems and complement results from user studies. An example based on infusion pumps, used in chemotherapy to infuse doses over a period, is employed to demonstrate the utility of the framework. The framework makes it possible to model the interactive tasks necessary to configure the pumps and start the infusion. The results of the analysis indicate situations where the operator is unable to carry out the task because of omission errors. These results are in line with experimental results reported in the literature, and may provide more detailed hypotheses that can be validated experimentally.
PLA short sub-micron fiber reinforcement of 3D bioprinted alginate constructs for cartilage regeneration

In this study, we present an innovative strategy to reinforce 3D-printed hydrogel constructs for cartilage tissue engineering by formulating composite bioinks containing alginate and short sub-micron polylactide (PLA) fibers. We demonstrate that Young’s modulus obtained for pristine alginate constructs (6.9 ± 1.7 kPa) can be increased threefold (up to 25.1 ± 3.8 kPa) with the addition of PLA short fibers. Furthermore, to assess the performance of such materials in cartilage tissue engineering, we loaded the bioinks with human chondrocytes and cultured in vitro the bioprinted constructs for up to 14 days. Live/dead assays at day 0, 3, 7 and 14 of in vitro culture showed that human chondrocytes were retained and highly viable (∼80%) within the 3D deposited hydrogel filaments, thus confirming that the fabricated composites materials represent a valid solution for tissue engineering applications. Finally, we show that the embedded chondrocytes during all the in vitro culture maintain a round morphology, a key parameter for a proper deposition of neocartilage extracellular matrix.