Miracle-dz/UniFAR-FTUs huggingface dataset:
Adjuvant Chemotherapy For Pancreatic Cancer - Can It Really Be Recommended? Conclusions From The Reassessment Of ESPAC-1 Study

Context According to the current guidelines, adjuvant chemotherapy is an integral part of the treatment concept for advanced pancreatic cancer. Randomised controlled studies showed that postoperative chemotherapy prolongs survival and reduces the recurrence rate. Objective The aim of our project was to analyse the validity of the most important study on this topic (ESPAC-1) by evaluating the data published in four publications (study design 1993, trial progress report 1997, interim results 2001, final results 2004). Design Our detailed analysis of the validity of the ESPAC-1 trial included the study design, recruitment period, patient selection, randomisation, changes in the protocol, participating institutions, homogeneity of subjects, surgical quality, statistical methods and interpretation of results. Results We identified several shortcomings in the patient selection, participating clinics, randomisation, changes in the protocol, surgical quality, statistics and evaluation of the results. Conclusion Although all analyzed papers concerned the same trial, the detailed evaluation revealed many inconsistencies. We therefore conclude that the validity of the ESPAC-1 trial is not sufficient to make a recommendation for adjuvant chemotherapy for advanced pancreatic cancer.
How does paw pad of Canine attenuate ground impacts: a micromechanical finite element study

28 29 Background. Digitigraded mammals, e.g. dogs and cats, stand or walk on their digits or toes. 30 Their paw pads beneath the digits or toes, rather than the entire sole of the foot, are in contact 31 with the ground surface during locomotion. Digitigrades generally move more quickly and 32 quietly than other animals. So far, little is known about the micro-scale structural 33 characteristics of digitigrades' paw pads and its connection with the superior biomechanical 34 functioning of their feet. 35 Methods. In this study, we investigated the micro-structure of the paw pad of German 36 shepherd dog (GSD) using SEM and histological examination, and assessed the 37 biomechanical functions of the micro-structured epidermis layer by using dynamic finite 38 element (FE) simulations. 39 Results. We found that there exists a thick layer of stratified epithelium of a honeycomb like 40 structure with conical protuberances (i.e. dermal papilla) embedded in each cell unit. Our FE 41 simulation analyses revealed that this specially structured layer is capable of effectively 42 attenuating the ground impact across a range of impact velocities. Moreover, this cushioning 43 capacity becomes more pronounced with increased impact velocity. More importantly, this 44 layer can also significantly reduce the mechanical stress transmitting to the soft dermal 45 papillae and dermis by using an off-loading mechanism. 46 Discussion. This would provide more insights into the biomechanical functioning of the 47 PeerJ Preprints | https://doi.org/10.7287/peerj.preprints. 2340v1 | CC BY 4.0 Open Access | rec: 4 Aug 2016, publ: 4 Aug 2016 digitigrade's paw pads, and also facilitate the development of bio-inspired ground contacting 48 components of robots and machines, and also the design of footwear and orthotics devices. 49
ALPHA V BETA 3 INTEGRIN EXPRESSION IN THE ENDOMETRIUM OF INFERTILE WOMEN WITH ENDOMETRIOSIS

Objectives : To evaluate the expression of Alpha V Beta 3 inlegrin (ccVpo) in infertile women with endometriosis in the midluteal in-phase endometrial biopsies. Design: Prospective controlled study. Setting: Department of Obstetrics and Gynaecology, Shatby University Hospital and Department of Pathology. Alexandria University. Subjects: Twenty five infertile females having stage I or II endometriosis (group I) and twenty fertile controls (group II). Interventions: Midluteal endometrial biopsies by suction pipette were earned out during the implantation window. Immunohistochemical staining for the expression of aVP3 integrins and progesterone receptors (PR) in endometrial samples were performed. Serum levels of estradiol and progesterone were measured at the same day of endometrial biopsy. Main outcome measures: aVf33 inlegrin was significantly reduced (p=0.001) in infertile patients with endometriosis (44%) compared to fertile controls (80%). Patients in group (I) had a statistically significant reduction (p=0.001) in the overall mean intensity score compared to women in group (II) (0.52+0.65vs 2.011.21). The expression of ocV[j3 was mainly glandular in both groups. However, in patients with positive inlegrin expression, the percentage of glandular expression as well as the mean intensity score was significantly reduced in group (I) compared to group (II) (p=0.001, p=0.0001 respectively). Hormonal levels were comparable between groups. The epithelial PRs were down regulated in all in-phase endometrial samples in both groups. Integrin expression was inversely correlated with epithelial PRs in the control group (r= 0.89, p=0.001) but no correlation was found in the endometriosis group (r=0.14, p = 0.39). Conclusion: aV|33 integrin expression is reduced during the window of implantation in infertile patients with stage I or II endometriosis denoting that defective uterine receptivity might be an unrecognized cause of associdated infertility in those women,
Cryopreservation of Human Unfertilized and Fertilized Oocytes

Received: July 11, 2012; accepted after revision: September 18, 2012 From the 1IVF Centers Prof. Zech, Bregenz, Austria, the 2Centre Hospitalier Inter Regional Cavell (CHIREC), Braine-l’alleud, Bruxelles, Belgium, the 3Reproductive Biology Associates, Atlanta, Georgia, USA, and the 4Iakentro Fertility Center, Thessaloniki, Greece. Correspondence: Dr. Barbara Wirleitner, IVF Centers Prof. Zech, A-6900 Bregenz, Romerstrase 2; e-mail: b.wirleitner@ivf.at  Introduction
Bioactive extracts from annona hypoglauca

Bioactive Extracts from Annona hypoglauca Ricardo C. dos Santos, Edvan A. Chagas, Antônio A. de Melo Filho, Jacqueline A. Takahashi, Ismael F. Montero, Pollyana C. Chagas, Pedro R. E. Ribeiro, Ana Cristina G. R. de Melo National Postdoctoral Program of CAPES, associated to POSAGRO/UFRR, Campus Cauamé, BR 174, s/n, Km 12, District Monte Cristo, CEP 69310-250, Boa Vista-RR, Brazil Embrapa, Rodovia 174, Km 8, Industrial District, CEP 69301970, Boa Vista-RR-Brazil; Post-Graduate Program in Chemistry, Center for Research and Graduate Studies in Science and Technology, UFRR, Campus Paricarana, CEP 69304-000, Boa Vista-RR-Brazil Department of Chemistry, Institute of Exact Sciences, Universidade Federal de Minas Gerais, UFMG, Av Antonio Carlos, no. 6627, Pampulha, CEP 31270-901, Belo Horizonte-MG-Brazil. Post Graduate Program in Biodiversity and Biotechnology, Bionorte, State Coordination of Roraima, UFRR, Campus Paricarana, CEP 69304-000, Boa Vista-RR-Brazil Post Graduate in Agronomy, POSAGRO, UFRR, Campus Paricarana, CEP 69304-000, Boa Vista-RR-Brazil. Post-Graduate in Natural Resources Program, Federal University of Roraima, Boa Vista-RR-Brazil. ricardocs.br@gmail.com
eview extural and thermal conductivity properties of a low density esoporous silica material benezer

In this study, the pore structure, tapped density and thermal conductivity properties of a new type of nanoporous silica material have been studied. We have applied nitrogen physisorption, high resolution scanning microscopy and Transient Plane Source thermal conductivity measurements to investigate these properties. The new mesoporous silica SNP have large BET surface area, 400–439 m2 g−1 and possess high
Diagnosis of combustion with water injection using high-speed visualization and CFDs

Direct water injection (DWI) was newly introduced as a promising NOx reduction method for ma-rine diesel engines thanks for its easy installation requiring no major engine modification. Its true potential, however, remains uncertain for lack of both numerical and experimental investigations. In this study, the ef-fect of DWI on decreasing flame temperature was objectively examined by two simulation codes of different combustion models and by flame temperature measurement in a visual engine based on the two-colour method using CMOS type camera. Simulation results were in good agreement with the measurement results in both flame propagation and flame temperature so that NOx reduction of DWI could be clearly explained. Moreover, it was found that DWI could result in more complicated combustion process than expected since preceding water vapour greatly affected the propagation and the air entrainment of the fuel spray. 1. Introduction
Effects of Sevoflurane and Propofol on Intestinal Ischemic Reperfusion Injury in Patients Undergoing Elective Open Infrarenal Abdominal Aortic Aneurysm Repair: A Randomized Controlled Trial

Background: We previously demonstrated that propofol had a protective effect on the intestine at risk after an ischemic injury in a rat model. The current study tested the hypothesis that such beneficial effects, so far mainly seen in the laboratory, are reproducible in humans.Methods: Seventy patients undergoing elective open infrarenal abdominal aortic aneurysm repair were randomized to receive general anesthesia with either propofol or sevoflurane. General anesthesia was induced with 3 µg/kg fentanyl, 0.2 mg/kg cisatracurium, and target-controlled infusion of propofol, set at a plasma target concentration of 4-6 µg/ml, or sevoflurane initially started at 8%. Anesthesia was maintained with target-controlled infusion of propofol (2-4 µg/ml) or sevoflurane (0.8-1.0 minimum alveolar concentration). Except for this, anesthetic and surgical management was the same in both groups. Serum intestinal fatty acid binding protein was taken as the primary outcome for evaluating intestinal injury. The secondary outcomes included other intestinal injury variables (serum endotoxin levels, serum diamine oxidase activity and the score of intestinal injury severity) as well as markers reflecting oxidative stress and systemic inflammatory response.Results: The levels of biomarkers reflecting intestinal injury were higher than baseline in both groups (all P<0.05). However, in sevoflurane-anesthetized patients, these variables increased significantly more than those in patients anesthetized with propofol (all P<0.05), whereas the scores of the intestinal injury severity didn't differ between two groups (P=0.53). Conclusions: Patients receiving propofol for abdominal aortic aneurysm repair surgery had less intestinal injury than patients receiving sevoflurane, which may be related to its better anti-oxidative property. Citation: Cai Li, Wu Yan, Jian- Tong Shen, Shi-Hong Wen, Ke-Xuan Liu. Effects of sevoflurane and propofol on intestinal ischemic reperfusion injury in patients undergoing elective open infrarenal abdominal aortic aneurysm repair: a randomized controlled trial. J Anesth Perioper Med 2015; 2: 126-35. Published on April 30, 2015. doi: 10.24015/JAPM.2015. 0018This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Lietuvos statistikos darbai Nr51

Premium estimation is a key concept in insurance mathematics. Estimation of the mean and variance of a total claim amount of a portfolio can be considered as necessary prerequisites for this. In turn, dividing the portfolio into homogeneous subportfolios can be considered as a first step towards finding those estimates. We consider the problem of estimating the claim intensity and propose a regression trees based approach for clustering the portfolio into homogeneous subportfolios in a situation where the durations of the policies differ and overdispersion is present. Several other generalizations are discussed. A case study involving Estonian casco insurance is included.
Liquidity and volatility in the American crude oil futures market

This article focuses on the impact of derivative markets on the American crude oil market. It first analyses the depth and liquidity of the market, and shows that there is a huge increase in activity from 1989 to 2003. Then the study focuses on prices volatility. The latter is separated into two components: an information component, that reflects a rational assessment of the information arrival, and an error component, that represents the noise introduced by the trading process. We show that a significant part of the volatility recorded during exchange trading hours is due to mispricing errors.
Anonymous Routing and Secure Transmissionin MANET (ARSTNET): Survey

MANET is an infrastructureless network consists of mobile nodes and the nodes can join and leave the network dynamically. Every movable device can act as router as well as end user. In MANET security is the major concern for the protected communication. Any user can accessible in the MANET, it doesn't depend whether they are legitimate network user or malicious attackers. Anonymity is needed, so that almost all the attacks are avoided. Providing anonymity to the routes, source and destination is a value added technique. Self organizing capability is the major profit and detriment of the MANET. In this paper discussed about security concern of MANET and includes one of the most efficient encryption schemes.
Seaweeds for Food and Industrial Applications

Marine macroalgae, or the term seaweeds, are plant-like organisms that generally live attached to rock or other hard substrata in coastal areas. The classification into divisions is based on various properties such as pigmentation, chemical nature of photosynthetic storage product, the organization of photosynthetic membranes, and other morphological fea‐ tures. Traditionally, they belong to four different groups, empirically distinguished since the mid-nineteenth century on the basis of color: blue-green algae (phylum: Cyanophyta, up to 1500 species), red algae (phylum: Rhodophyta, about 6000 species), brown algae (phylum: Ochrophyta, classes: Phaeophyceae, about 1750 species), and green algae (phylum: Chlorophyta, classes: Bryopsidophyceae, Chlorophyceae, Dasycladophyceae, Prasinophy‐ ceae, and Ulvophyceae, about 1200 species). However, each of these groups has microscop‐ ics, if not unicellular, represantatives. All seaweeds at some stage in their life cycles are unicellular, as spores or zygotes, and may be temporarily planktonic. The blue-green algae are widesperead on temperate rocky and sandy shores and have occasionally been acknowledged in seaweed floras. Seaweeds are found growing throughouth the world oceans and seas none is found to be poisonous (Bold and Wyne, 1985; Guiry, 2009; Lobban and Harrison, 2000). Why seaweed is important? Most people don’t realize how impor‐ tant marine macroalgae are, both ecologically and commercially. In fact, seaweeds are crucial primary producer in oceanic aquatic food webs. They are rich both in minerals and essential trace elements, and raw materials for the pharmaceutical and cosmetics industry (Chap‐ man, 1970). Seaweed is a very versatile product widely used for food in direct human consumption. Its classified taxonomically as algae and they represent a food group that is not normally ingested in unprocessed form to any great extent in Western societies. Humankind is no strangers to the use of algae as a food source. Even if seaweeds have been used as a human food since ancient times, particularly in the region bounded by China, the
Testing For Ethical Sensitivity To Responsible Conduct Of Research Among Multi National Stem Researchers

Michael Bowler, Michigan Technological University Susie Amato-Henderson, Michigan Technological University Tom Drummer, Michigan Technological University Joseph Holles, Michigan Technological University Joanna Schreiber, Michigan Technological University Ted Lockhart, Michigan Technological University Debra Charlesworth, Michigan Technological University Jingfang Ren, Michigan Technological University
Software Reliability Prediction and Improvement Strategies for Web Applications

Software reliability is an important aspect of software quality. Software reliability is defined as “the probability for failure-free operation of a program for a specified time under a specified set of operating conditions”. is one of the key attributes when discussing software quality. Software reliability for web applications is measure via different metrics and testing techniques. In this paper, we characterized the metric, techniques, errors for web applications. This paper also examine’s the potential for reliability improvement. Based on the characteristics of web applications and the overall web environment, we classify web errors and to check reliability using different metrics parameters.
Laboratory Data on Ices, Refractory Carbonaceous Materials, and Minerals Relevant to Transneptunian Objects and Centaurs

Information on the surface compositions of transneptunian objects (TNOs) and Centaurs is derived primarily from spectrophotometric or spectroscopic observations. The identification of the surface constituents and detailed studies of the surface composition depend on the availability of appropriate laboratory data. In particular, optical constants (complex refractive indices) are necessary to calculate synthetic spectra for different grain sizes or deal with components mixed in various ways. Observations of TNOs and Centaurs are made primarily in the wavelength region of reflected sunlight (0.3 10 μm). We review the general spectroscopic characteristics and available optical constants for the ices, refractory carbonaceous materials, and minerals that have been detected or are expected to be present at the surfaces of these objects.
Strategic Planning Formulation by using Reinforcement Learning

This study considers the similarities between strategic planning and reinforcement learning, then formulates the strategic planning to a reinforcement learning problem and solves it by using reinforcement learning methods. Increasing the environmental cataclysm and variations in today's world enforce all organizations such as universities, to have a strategic thought to increasing the effect answering time to their environmental needs, resource wasting reduction, leading the organization to a clear and executable direction and problem determination in On the other hand internal and external views. , computers have a key role in today's life. We try to relate between these two subjects. We use recommended method to computerize the strategic planning design for Noshahr-Chaloos Islamic Azad Universi of the university placed in compositional ty of Iran. The results show that the general strategic positionstrategies. Also the results present using intelligent methods to computerize the strategic planning have a very good future, although it is on beginning of its long path.
New Insights into Approaches to Evaluating Intention and Path for Network Multistep Attacks

The attack graph (AG) is an abstraction technique that reveals the ways an attacker can use to leverage vulnerabilities in a given network to violate security policies. The analyses developed to extract security-relevant properties are referred to as AG-based security evaluations. In recent years, many evaluation approaches have been explored. However, they are generally limited to the attacker’s “monotonicity” assumption, which needs further improvements to overcome the limitation. To address this issue, the stochastic mathematical model called absorbing Markov chain (AMC) is applied over the AG to give some new insights, namely, the expected success probability of attack intention (EAIP) and the expected attack path length (EAPL). Our evaluations provide the preferred mitigating target hosts and the vulnerabilities patching prioritization of middle hosts. Tests on the public datasets DARPA2000 and Defcon’s CTF23 both verify that our evaluations are available and reliable.
The application of a neural network methodology to the analysis of a dyeing operation

The purpose of a dyeing process is to impart into a fiber a color that has desirable qualities through the use of a bath solution. The success of an operation is dependent on a variety of factors including fiber content, dye composition, dyebath pH, time, and temperature. In the event of a failed run, the addition of a correct amount of each dye that will move the dye run from a fail condition to a pass condition is a subjective judgement of an experienced operator. This paper presents a neural network approach for analyzing the dyeing process. Predictions of dye additions were obtained with promising results.
Facilitating Therapeutic Expression and Communication through Play

Objective: To present several examples that illustrate the effectiveness of play interventions in a hospital context facilitated by child life specialists and other health care providers. Clinical Presentation and Intervention: Specific examples include children between the ages of 4 and 10 with serious illnesses (cancer, cystic fibrosis, heart disease) and those having experienced the death of a loved one. Interventions include child-directed play as a therapeutic modality. Conclusion: The opportunities afforded by play and creative arts for self-expression, mastery, and control are of paramount importance for children experiencing the anxiety or psychological trauma often associated with a serious illness or with the death of a loved one.
Post-operative Weight Gain After Total Knee Arthroplasty: Prevalence and Its Possible Attenuation Using Intraoperative Sensors

As the proportion of adults with obesity continues to climb, so too does the need for total knee arthroplasty. Unfortunately, total knee replacement patients often experience post-operative weight gain, despite improved joint function. The purposes of this study were: 1) To execute a literature meta-analysis in order quantify the changes in body mass that are typically observed following TKA, and 2) Evaluate data from a prospective, multicenter study to assess any trends towards weight loss in a group of “balanced”, sensor-assisted TKA patients. The literature review found that average proportion of patients who had weight gain after TKA is 47% to 66%. In literature, the average post-operative weight gain was 9.5 lbs. (1.6 kg/m 2 BMI increase), up to 14 lbs. (2.3 kg/m 2 ). In the multicenter study, only 30.4% of patients and 36.9% of patients exhibited weight gain at 6 months and 1 year, respectively. At the 1-year interval, this indicates an 11% decrease from reported averages (p=0.049), up to 29% as reported by the NIH (p<0.001). The average weight gain in the multicenter patient group was 4.3 lbs. (0.72 kg/m 2 BMI increase) at 6 months, and 3.5 lbs. (0.58 kg/m 2 ) at 1 year, both of which are non-clinically meaningful. The average weight loss of those in the non-gaining group was 7.8 lbs. (1.3 kg/m 2 ) at 6 months and 9.6 lbs. (1.6 kg/m 2 ) at 1 year. Both of these values are clinically meaningful. This evaluation demonstrates that weight gain after TKA is prevalent, but ensuring soft-tissue balance (via technologies such as intraoperative sensing) may help mitigate this expected increase in body mass. Keywords : total knee arthroplasty, increased BMI, intraoperative sensors, weight gain, obesity