Miracle-dz/UniFAR-FTUs huggingface dataset:
Variations in Immediate-early Genes Encoding c-Fos, c-Jun and IER5 Transcription Factors are Associated with Ischemic Stroke

Transcription factors make a great contribution in the regulation of mechanisms, which are involved in the preand post-stroke events. The main goal of the current study was to evaluate the potential association of single nucleotide polymorphisms FOS (rs7101, rs1063169), JUN (rs11688) and IER5 (rs6425663) with ischemic stroke in Armenian population. A total 161 patients with ischemic stroke and 165 controls were involved in this study. Transcription factors were genotyped using polymerase chain reaction with sequence-specific primers (PCR-SSP). Association of genotype, allelic and carriage frequencies with ischemic stroke was assessed using Pearson's Chisquare test. Multiple test corrected p values less than 0.05 were considered significant. The data obtained demonstrated a significant negative association between the FOS rs1063169*T, JUN rs11688*A and IER5 rs6425663*T minor alleles with ischemic stroke. On the other hand, the frequency distribution of rs7101*T minor allele of FOS gene and its carriage rate in the group of patients were significantly higher than in controls. Our results indicate that the minor alleles of FOS rs1063169, JUN rs11688 and IER5 rs6425663 SNPs can be considered as protective against ischemic stroke, whereas the minor allele of FOS rs7101 SNP represents a risk factor for this disease.
Response surface methodology can be used to predict photoinactivation of foodborne pathogens using Rose Bengal excited by 530 nm LED

In this work, the photodynamic bactericidal effect of Rose Bengal (RB), combined with green LED light, against Staphylococcus aureus and Salmonella Typhimurium, was investigated. The interaction of RB concentration and illumination time was evaluated using a response surface methodology, and a second‐order polynomial empirical model was adjusted to the experimental data. The derived model predicted the combined influences of these factors on S. aureus and S. Typhimurium counts, in accordance with predictions and experimental observations (R² = 0.8483 and p = .0013 for S. aureus; R² = 0.9191 and p = .0001 for S. Typhimurium). Total inhibition of S. aureus and S. Typhimurium was observed when applying a light dose of 0.125 J cm⁻² and 152.0 J cm⁻², respectively. The treatments also showed loss of membrane integrity, morphological changes, and internal cell structural alterations. In sum, the polynomial model developed could provide accurate information on the combined influences of RB and green LED light in aPDT treatment and, that this combination was able to inactivate S. aureus and S. Typhimurium.
How does Soft Information Affect External Firm Financing? Evidence from Online Employee Ratings

We analyze the effects of equity market investors having access to soft information, such as online employee ratings of firms, on their external financing and investment policies. We develop testable hypotheses using a theoretical framework in which the insiders of a firm have private information about its intrinsic value, but where outsiders have access to soft information signals imperfectly correlated with this intrinsic firm value. We test these hypotheses using a large sample of around 1.1 million employee ratings from the Glassdoor website covering a sample of 2842 public firms during 2008 to 2017. We find that firms with higher average online employee rating realizations are associated with algebraically greater abnormal stock returns upon an equity issue announcement; a greater propensity to have positive abnormal stock returns upon such an announcement; a greater propensity to issue equity rather than debt to raise external financing; higher annual investment expenditures; greater participation by institutional investors in their seasoned equity offerings (SEOs); and better long-run post-SEO operating performance. Our identification strategy makes use of a difference-in-differences (DID) methodology relying on the staggered implementation of laws protecting the First Amendment Rights of citizens (anti-SLAPP laws) across US states.
TRIPLE PSYCHO-ORGANIZATIONAL SUPPORTS FOR CHANGE MANAGEMENT PROCESS

Abstract: In this ever-changing era, organizations are required to be able to answer new challenges that will emerge such as globalization, rapid flow of information and rapid technological developments, resulting in increasing demand for quality employees. This forced the organization to be able to manage existing human resources properly and effectively in order to be able to keep up with the flow of change. Therefore, every organization will try to increase the commitment of its employees, especially the commitment to change. Employees are required to have a high commitment in dealing with change and have behaviors that support change, so that they are in accordance with the changing times and demands of the community, so that the organization can still exist and not be abandoned by its users. This study aims to develop a model to find out how to encourage individual behavior support to change by increasing individual commitment to change within an organization. Change oriented leadership, employee adaptability and the internalization of organizational values which we termed as three psycho-organizational supports are indicated as important antecedents to commitment to change, which in turn will encourage individual behavior to support to change. Research Methods: Data was collected from 116 respondents as employees in Statistical Bureau Province, Indonesia. The analytical method uses SEM (Structural Equational Modeling) to test the hypotheses. Sobel Test is used to test the effect of mediating variables in the model. Finding: Behavior to support change is strongly influenced by individual commitment to change, the higher the individual's commitment to change, the more they will encourage the individual to have behaviors that support change. While individual commitment to change is influenced by several factors such as change-oriented leadership, employee adaptability and organizational values. These three factors have a positive and significant influence on individual commitment to change. Keywords: Change-oriented leadership; employee adaptability; organizational values; commitment to change; behavior to support to change.
Aripiprazol en dosis bajas para somnolencia diurna excesiva asociada a uso de haloperidol: un reporte de caso

La somnolencia diurna es un efecto adverso frecuentemente asociado al uso de antipsicoticos en pacientes con esquizofrenia. Presentamos el caso de una mujer de 43 anos con esquizofrenia y tratamiento antipsicotico desde hace 24 anos, que inicialmente, presento mala respuesta a antipsicoticos clasicos de baja potencia, llegando a lograr estabilizar los sintomas psicoticos por mas de 10 anos con uso de haloperidol. Sin embargo, con este tratamiento presento somnolencia diurna que llego a ser un efecto adverso importante limitando su funcionalidad y calidad de vida. Luego de anadirse primero 3,75 mg y luego 7,5 mg de aripiprazol, mejoro hasta un 80% la somnolencia sin exacerbacion de los sintomas psicoticos.
Implikationen des [ 11 C]Cholin PET/CT Signals für die Strahlentherapieplanung bei lokalisierten Prostatakarzinomen

Ziel der Studie war es die Wertigkeit der [ 11 C]Cholin PET/CT fur die Planung einer intensitatsmodulierten Radiotherapie (IMRT) mit dem Konzept des Dose paintings beim primaren Prostatakarzinom zu evaluieren. Mittels Koregistration von Histologie und [ 11 C]Cholin PET/CT PET/CT im 3D Raum wurde das [ 11 C]Cholin-Signal bei 28 Patienten auf seine Treffsicherheit bezuglich der Karzinomdetektion unter Zuhilfenahme von SUV-Werten hin untersucht. Insgesamt gelang bei 50% der Patienten eine Tumordetektion. Ursachen fur die mangelhafte Detektionsfahigkeit scheinen zum einen die Tumorkonfiguration (insbesondere Volumen 3 ), zum anderen pathologisch erhohte SUV-Werte in Regionen mit benignen prostatischen Veranderungen wie BPH, Prostatitis und HGPIN zu sein. Als Grundlage fur die Planung einer IMRT mit dem Konzept des Dose Painting beim primaren Prostatakarzinom scheint die [ 11 C]Cholin PET/CT unseren Daten zufolge nicht geeignet.
Benchmarking joint multi-omics dimensionality reduction approaches for cancer study

High-dimensional multi-omics data are now standard in biology. They can greatly enhance our understanding of biological systems when effectively integrated. To achieve this multi-omics data integration, Joint Dimensionality Reduction (jDR) methods are among the most efficient approaches. However, several jDR methods are available, urging the need for a comprehensive benchmark with practical guidelines. We performed a systematic evaluation of nine representative jDR methods using three complementary benchmarks. First, we evaluated their performances in retrieving ground-truth sample clustering from simulated multi-omics datasets. Second, we used TCGA cancer data to assess their strengths in predicting survival, clinical annotations and known pathways/biological processes. Finally, we assessed their classification of multi-omics single-cell data. From these in-depth comparisons, we observed that intNMF performs best in clustering, while MCIA offers a consistent and effective behavior across many contexts. The full code of this benchmark is implemented in a Jupyter notebook - multi-omics mix (momix) - to foster reproducibility, and support data producers, users and future developers.
Recommending Activities for Mental Health and Well-Being: Insights From Two User Studies

Engaging in daily activities that engender positive affect (e.g., exercise and socializing) is critical for emotional well-being and is effective in reducing clinical depression. However, current digital mental health interventions have not exploited recommender approaches to encourage such healthy behaviors. This paper tests the feasibility of recommending personalized, healthy activities to users. Using two mobile applications, we collected high-quality data about specific healthy activities from two populations: a clinical sample diagnosed with a mood disorder (n = 318 activities/user) and a non-clinical sample (n = 59 activities/user). Activities were labeled with a type (e.g., social, leisure, work) and rated for their impact on mood. We used a probabilistic Naive Bayes (NB) Classifier and a Support Vector Machine (SVM) to model the activities as a bag-of-words to predict mood outcomes. We separate the analysis into a generalized model where we pooled all participants, comparing it with a personalized model. In both the clinical and non-clinical samples, there was a significant difference between the models. Both NB and SVM favored the personalized model after collecting 58.92 (SD = 20.96) activities. This research sheds light on recommendations for mental health, showing that personalization is key for recommending the right activity to each user.
MUSCULOSKELETAL DISORDERS AND PHYSIOLOGIC CHANGES OF PREGNANCY

Pregnancy is a condition in which a combination of biochemical, hormonal, and vascular changes may results in a wide variety of musculoskeletal disorders. In the postpartum period, baby care may lead to specific disorders of the mother's upper limbs. Virtually all women experience some degree of musculoskeletal discomfort during pregnancy. We propose to review the main musculoskeletal disorders during pregnancy.
Effectiveness of Self-Care in Reducing Symptoms of Secondary Traumatic Stress

Social workers who work with traumatized clients have an increased risk of experiencing secondary traumatic stress (Sprang, Whitt-Woosley, & Clark, 2007). Up to 70% of workers reported at least one symptom of secondary traumatic stress in the past week (Bride, Robinson, Yegidis, & Figley, 2004). Secondary trauma was also believed to be a significant reason workers in the human services field left their employment (Bride, 2007). High turnover in human services organizations may lead to high recruiting and training costs and can also reduce the efficacy of services to clients (Harrison & Westwood, 2009). An intervention that was found to be successful in reducing the symptoms of secondary traumatic stress for social workers was selfcare (Lee & Miller, 2013). The research identified five main types of self-care including physical, emotional, psychological, spiritual, and professional. The findings supported the standpoint that self-care was effective in reducing symptoms of secondary traumatic stress for social workers. Being proactive and building a strong foundation of support with family, friends, colleagues and other professionals may be a key to reduce the effects of the stress experienced by social workers (Bloomquist et al., 2015; Eastwood & Ecklund, 2008; Killian, 2008). By reducing the risks of STS for social workers, employees may experience increased well-being (Goncher, Sherman, Barnett, & Haskins, 2013), employers may have greater staff retention (Bride, 2007), while clients will receive more consistent and a higher quality of care (Harrison & Westwood, 2009). EFFECTIVENESS OF SELF-CARE 3 Acknowledgements I would like to acknowledge and thank everyone who has supported me through completing this research. First I would like to thank the professors, instructors, and staff with the School of Social Work at the University of St. Thomas and St. Catherine’s University. The knowledge and skills that they have taught were critical in seeing this research to completion. I would also like to thank my committee, include my chair, Sarah Ferguson, who was a great motivator and very grounding throughout the research process. To my other committee members Lisa Thibodeau and Julie Krings, thank you for your support and encouragement through this entire process. I would like to thank my cohort; their kindness, compassion, encouragement, and humor are second to none. A note of gratitude also to my friends and coworkers who were patient and supportive during this past year. Finally, a heartfelt thank you to my family. Your patience, support, understanding and willingness to take on extra tasks has been more than I could have hoped for. Andrea and Josie, I am so blessed to have you in my life. EFFECTIVENESS OF SELF-CARE 4
Hypertension and Related Risk Factors Among Clients on Combined Antiretroviral Therapy in Nigeria

Hypertension is a major challenge in human immunodeficiency virus (HIV) infected people globally. A prospective, cross-sectional study comprising two hundred and eighteen HIV-infected patients was conducted in Antiretroviral Therapy Clinic of General Hospital, Offa between November 2015 and December, 2016. Patients’ blood pressure was evaluated using Omron automated blood pressure monitor following standard procedures. Dual weight and height balance was utilized to measure the weight and height of the subjects. Hypertension incidence among patients receiving combined antiretroviral therapy (cART) was 34%, while those that were yet to start cART was 9.6 %. In HIVinfected women on cART, occurrence of hypertension was high (75.5%) as compared to men (24.5%). The hypertension pervasiveness in HIV-infected patients on cART was 75.5% in women and 24.5% in men. Risk factors that were markedly linked with hypertension among patients on cART include body mass index (OR: 3.29,95% CI:1.21-2.27; p< 0.050), sedentary lifestyle (OR: 1.63, 95% CI:1.20-5.38; p < 0.043), age (OR: 2.17, 95% CI: 1.22-2.33; p< 0.004) and gender (OR: 1.63, 95% CI: 0.85-2.41; p < 0.037). Patients on cART were found to have higher hypertension prevalence than cART-naive. The cART, however, is not a risk factor for hypertension.Bangladesh Pharmaceutical Journal 21(1): 35-41, 2018
Molecular stratification of colorectal cancer populations and its use in directing precision medicine

ABSTRACT Introduction: The intrinsic heterogeneity of colorectal cancer (CRC) makes it difficult to determine which patients will benefit from adjuvant or systemic therapy and which patients will not require further treatment beyond surgical resection. This had led to a generalized ‘one size fits all’ approach to therapy. Such heterogeneity also makes it a great challenge to predict which patients might respond to targeted therapies. Precision medical diagnostics now hold promise to address these new challenges. Areas covered: The authors first review various molecular/genomic classification studies of colorectal cancer, including the prognostic role of MSI (microsatellite instability), CIN (chromosomal instability), and driver genes such as KRAS, NRAS, BRAF, PIK3CA and TP53, as well as our recent finding revealing a new prognostic role of APC and partnering mutations with KRAS and TP53. The authors then discuss prediction of treatment response for either adjuvant therapy or systemic targeted therapy (e.g. anti-EGFR therapy) as well as the effect of tumor sidedness. Expert commentary: There is an urgent need for more precise molecular classification to stratify adjuvant therapy and systemic targeted therapy to ultimately facilitate individualized treatments. Sequencing of APC may have clinical utility in the routine staging and potential therapeutic assignment for CRC patients.
Factors Affecting Stress in Elderly Staying in Public Nursing Home in Yogyakarta, Indonesia

The elderly people are vulnerable to the impact of stress. Previous studies reported that the elderly who had lived in nursing homes may be stimulated stress more often than other groups. The purpose of this study is to examine the factor affecting stress in elderly who staying in public nursing homes in Yogyakarta, Indonesia. A total of 178 elderly people were recruited from three public nursing homes. Statistical analyses were conducted by employing descriptive and logistic regression. The finding also showed that the model of the logistic regression accounted 33.4% of the variance in stress in elderly staying in public nursing home. The result showed that the strongest contribution to stress in elderly was activity of daily living, followed by social support, perceived health status, and education.
Decentralized Dynamic Event-Triggered $\mathcal {H}_{\infty }$ Control for Nonlinear Systems With Unreliable Communication Channel and Limited Bandwidth

This article investigates the dynamic event-triggered <inline-formula><tex-math notation="LaTeX">$\mathcal {H}_{\infty }$</tex-math></inline-formula> control problem for nonlinear networked control systems with unreliable communication channel, variable communication delays, and limited bandwidth. The nonlinear plant is represented by discrete-time polynomial fuzzy model. First, a decentralized dynamic event-triggered mechanism is proposed to determine whether the measured data are transmitted or not, and in order to exclude data collision caused by limited bandwidth, novel try-once-discard and flexible round-robin scheduling protocols are proposed to assign communication channel to certain sensor node. Then, Bernoulli distribution is employed to model the unreliable communication channel, and a new random sequence is developed to model the received data sequence under the effect of data losses and scheduling protocols. Furthermore, a discrete-time stochastic system model with both state and error delays is constructed, and sufficient conditions in the form of sum-of-squares are developed for the design of <inline-formula><tex-math notation="LaTeX">$\mathcal {H}_{\infty }$</tex-math></inline-formula> controllers such that the closed-loop system is stochastically stable and preserves guaranteed <inline-formula><tex-math notation="LaTeX">$\mathcal {H}_{\infty }$</tex-math></inline-formula> performance. Finally, two simulation examples are provided to illustrate the effectiveness of the proposed results.
INDIGENOUS TRADITION BASED-TOURISM DEVELOPMENT: FOREIGN TOURIST’S MEMORABLE TOURISM EXPERIENCE IN MENTAWAI, INDONESIA

Purpose: This study examines the foreign tourist’s MTE on the indigenous tradition with the objective to find out the foreign tourists’ MTE and its effect on revisit intention and intention to recommend. It is conducted on 51 foreign tourists visiting Mentawai from April to June 2018. Methodology: Convenient sampling is used for the sampling method. Primary data are collected from survey. Result: The result shows that MTE is good (higher) which has a positive significant relationship with the revisit intention due to that the t value of this variable is greater than 1.96. , and the path coefficient is 0.619. It indicates the higher MTE which will have an effect on the high opportunity to revisit intention. The effect of MTE on intention to recommend also has a positive significant relationship. The path coefficient also indicates a positive sign, meaning the higher MTE has effect on the higher intention to recommend. Thus, foreign tourists experiencing Mentawai cultural tourism has positive MTE effecting positively tourists’ revisit intention and intention to recommend. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of the Indigenous Tradition Based-Tourism Development: Foreign Tourist’s Memorable Tourism Experience in Mentawai, Indonesia is presented in a comprehensive and complete manner.
Interference of Spread-Spectrum EMI and Digital Data Links under Narrowband Resonant Coupling

In this paper, the effects of electromagnetic interference (EMI) coupled to a radio-frequency (RF) communication channel by resonant mechanisms are investigated and described in the framework of Shannon information theory in terms of an equivalent channel capacity loss so that to analyze and compare the effects of non-modulated and random Spread Spectrum (SS) modulated EMI. The analysis reveals a higher EMI-induced capacity loss for SS-modulated compared to non modulated EMI under practical values of the quality factor Q, while a modest improvement in the worst case capacity loss is observed only for impractical values of Q. Simulations on a 4-quadrature amplitude modulation (4-QAM) digital link featuring Turbo coding under EMI resonant coupling reveal that SS-modulated EMI gives rise to higher bit error rate (BER) at lower EMI power compared non-modulated EMI in the presence of resonant coupling for practical values of Q, thus suggesting a worse interfering potential of SS-modulated EMI.
Green together? The effects of companies’ innovation collaboration with different partner types on ecological process and product innovation

ABSTRACT This paper investigates the effect of companies’ innovation collaboration with different partner types on the emergence of different typologies of ecological innovation (EI), specifically process- and product-EI. Econometric analyses, based on a sample of 546 German manufacturing companies collected as part of the Community Innovation Survey, indicate a differential effect of collaboration with individual partner types. Specifically, we find that collaboration with consumers is associated positively with both process- and product-EI, whereas collaboration with universities and suppliers is associated positively only with process-EI. Collaboration with enterprise customers and competitors is neither associated with process-EI nor product-EI. Our results shed light on the mechanisms within the recently established open eco-innovation mode and emphasise the importance for theory and practice of distinguishing among collaboration partners, contingent on the underlying typology of EI. We discuss important implications for theory and practice.