Miracle-dz/UniFAR-FTUs huggingface dataset:
Docetaxel plus 5-fluorouracil and cisplatin (DCF) induction chemotherapy for locally advanced borderline-resectable T4 esophageal cancer.

BACKGROUND This study aimed to evaluate the efficacy of docetaxel plus 5-fluorouracil and cisplatin (DCF) induction chemotherapy for locally advanced borderline-resectable T4 esophageal cancer. PATIENTS AND METHODS We retrospectively analyzed data regarding thirty patients with borderline-resectable T4 tumor who received either DCF or cisplatin plus 5-fluorouracil (FP) as induction chemotherapy. RESULTS The overall response rate was significantly better for the DCF group than the FP group. In the DCF group, 6/16 patients achieved a grade 2 histological post-chemotherapeutic effect after treatment, compared to 1/14 in FP group. Except for myelotoxicity, no other significant differences in toxicity were observed during induction chemotherapy between groups. The DCF regimen did not result in increased postoperative complications compared to the FP regimen. Postoperative recurrence or distant metastasis was observed in 7/10 of FP patients and 5/12 of DCF patients. CONCLUSION DCF induction chemotherapy may be an option for conversion therapy of initially unresectable, locally advanced esophageal cancer.
A survey of general practitioners’ opinions and perceived competencies in teaching undergraduate psychiatry

INTRODUCTION There have been increasing numbers of suggestions that general practitioners (GPs) should be more involved in undergraduate teaching. This study looks at GPs' opinions regarding those best placed to deliver undergraduate psychiatry teaching and what areas of the curriculum GPs feel competent to teach. The study aims to inform decisions about the contribution of GPs to the delivery of undergraduate teaching in psychiatry. METHOD A questionnaire asked GPs about teaching undergraduate psychiatry in both general and specialist areas. RESULTS The response rate was 61%. Over a third of GPs felt competent to teach psychiatry to undergraduates in a general practice setting, and the vast majority thought psychiatry should be taught by a combination of GPs and psychiatrists. GPs felt least confident about teaching child psychiatry and addiction. CONCLUSIONS Many GPs would like to be involved in teaching psychiatry and would welcome further training. The study suggests that there is capacity for increasing teaching in collaboration with GPs.
Intrafamilial clinical heterogeneity of CSPP1‐related ciliopathy

Intrafamilial Clinical Heterogeneity of CSPP1-Related Ciliopathy Tawfeg Ben-Omran,* Reem Alsulaiman, Hussein Kamel, Ranad Shaheen, and Fowzan S. Alkuraya* Department of Pediatrics, Section of Clinical and Metabolic Genetics, Doha, Qatar Department of Radiology, Hamad Medical Corporation, and Weill Cornell Medical College, Doha, Qatar Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
A multivariable modeling approach for the design of Power Electronics Based DC Distribution Systems in diesel-electric vessels

The benefits of using Power Electronics Based DC Distribution Systems in diesel-electric vessels are well known. However, some aspects must be deeply analyzed to guarantee a safe, robust and stable system by design. A multivariable DC Distribution System mathematical model is presented and described in this work, where all the transmission lines and filters impedances are considered. The model has been tackled under a holistic approach in which the average small signal model of the drives/converters can be easily added and `connected' to the main grid model. The stability and signal power quality analysis, as well as the design of controls and active damping strategies can be conducted through this mathematical model at low computational cost. The usefulness of this model in the early design stages is thus presented in this paper through its application over a realistic design scenario.
The Fast Reject Schema for Part-in-Whole 3D Shape Matching

This paper proposes a new framework for an efficient detection of template shapes within a target 3D model, or scene. The proposed approach distinguishes from the previous literature because the part-in-whole matching between the template and the target is obtained by extracting off-line only the shape descriptor of the template, while the description of the target is dynamically and adaptively extracted during the matching process. This novel framework, called the Fast Reject schema, exploits the incremental nature of a class of local shape descriptors to significantly reduce the part-in-whole matching time, without any expensive processing of the models for the extraction of the shape descriptors. The schema have been tested on three different descriptors and results are discussed in details. Experiments show that the gain in computational performances does not compromise the accuracy of the matching results.
A new PRB sharing scheme in dual-hop LTE-advanced system using game theory

Relaying is a promising technique for the next generation cellular networks. It is highly recommended in the 3GPP LTE-Advanced because it is expected to satisfy the ever growing capacity and coverage demands in a cost-efficient way. Yet, in order to fully exploit the benefits of relaying, we should examine the radio resource allocation between the eNB and the relay nodes. In this paper, we propose a dynamic Physical Resource Blocks (PRBs) allocation scheme in a dual-hop LTE-advanced by using game theory. We define a new repeated game in which a selfish node can achieve cooperative spectrum opportunities sharing under the threat of punishment. Simulation results show that the proposed scheme significantly improves the spectrum utilization and total achieved throughput in the system. We also demonstrate that the game rapidly attain Pareto-efficiency.
GUIDANCE OF EFSA

6 This Guidance provides instructions on how to identify and select “scientific peer-reviewed open literature” as 7 required by Article 8(5) of Regulation (EC) No 1107/2009 on the placing of plant protection products on the 8 market and how to report it in a dossier. The Guidance is intended for: (1) applicants submitting dossiers on 9 active substances of plant protection products under Regulation (EC) No 1107/2009; (2) EU Member States’ 10 competent authorities evaluating the dossiers and preparing the draft assessment reports; and (3) the European 11 Food Safety Authority (EFSA), responsible for drawing conclusions on the dossiers. This Guidance is based 12 upon the principles of systematic review, to ensure methodological rigour and transparency, and to minimise bias 13 in the identification and selection of scientific information in dossiers. It is compatible with existing OECD 14 Guidance documents for the preparation of active substances dossiers. This Guidance acknowledges that peer15 review does not guarantee rigour, validity or transparency of scientific literature and that potentially admissible 16 (i.e. methodologically sound and unbiased) scientific evidence may originate from non-peer-reviewed sources. 17 Accordingly, the “scientific peer-reviewed open literature” referred to in Article 8(5) of Regulation (EC) No 18 1107/2009 is given a wider definition, to enable inclusion of non-peer-reviewed scientific literature, where 19 justified. Research recommendations include clarification of the types of literature and information sources most 20 appropriate/useful for dossiers; assessment of publication bias in pesticide research, which would help to define 21 the level of detail of the searching requirements; and clarification of appropriate methods for appraising data 22 reliability in dossiers. 23
Foraging Behavior of Surf Scoters (Melanitta Perspicillata)and White-Winged Scoters (M. Fusca) in Relation to Clam Density: Inferring Food Availability and Habitat Quality

Abstract Birds are known to modify their foraging behavior in relation to food availability. Once understood, these relationships can be used to draw inferences about relative food availability and habitat quality. We measured foraging behavior of Surf Scoters (Melanitta perspicillata) and White-winged Scoters (M. fusca) feeding on clams during winter in the Strait of Georgia, British Columbia, to evaluate the relative quality of the foraging landscape for wintering scoters. Because clam biomass does not increase appreciably during winter through growth or recruitment, scoters are faced with a depleting and potentially exhaustible food supply. Along with this temporal variation, clam densities vary widely by site. We considered the influence of variation in clam density on scoter foraging behavior, along with other factors known to affect foraging in other sea duck species, such as season, sex, age, and environmental attributes. Clam-capture success (clams captured per dive) and foraging effort (minutes underwater per hour) of Surf Scoters were not related to variation in clam density. Clam-capture success of White-winged Scoters was unrelated to clam density; however, their foraging effort was negatively related to clam density, though varying by only 4 min across the range of observed clam densities. For both species, foraging behavior was generally more strongly related to other factors, especially seasonal and age effects. These results suggest that (1) observed variation in clam density was relatively minor from the perspective of foraging scoters and (2) our study site constituted high-quality winter habitat in which scoters were not constrained by food availability. Comportamiento de Forrajeo de Melanitta perspicillata y M. fusca con Relación a la Densidad de Almejas: Inferencias sobre la Disponibilidad de Alimento y la Calidad del Hábitat
77-79 Ghz Stacked Low Noise Amplifier for Automotive Radar

This paper describes the three stage stacked low noise amplifier for automotive radar applications. Stack structure is employed to overcome the inability of MOSFETs to operate at high voltage levels, as stacked MOSFETs can tolerate k × V max where V max can be chosen to be near the breakdown voltage of a single device. Realized in 65nm CMOS process, the stacked amplifier provides a gain of 15 dB with noise figure of 3.5 dB at 79 GHz. The amplifier draws 28.2 mA current from a 3V supply. To examine the nonlinear behavior of the amplifier Volterra analysis is performed, second and third order harmonic distortions are determined. The effect of feedback on the output resistance is examined using Blackman’s analysis. Sensitivity analysis of the stacked LNA is also performed to determine the effect of parameter variations on the circuit performance.
Excitatory and Inhibitory Memristive Synapses for Spiking Neural Networks

Neuromorphic chips are composed of silicon neurons, synapses and memories for synaptic weight. Moreover we can find a fourth part dedicated to synaptic plasticity algorithm. Even though we can find some low-power silicon neurons, the power consumption reduction of synapses, memories and plasticity algorithm is not enough explored. Since memristor coming-out in 2008, neuromorphic designers investigate the possibility of using memristors as plastic synapses due to their intrinsic property of plasticity. This nanocomponent gathers the function of synapse, the weight storage and the plasticity. So far, the proposed solutions cannot manage both excitatory and inhibitory memristive synapses with one single design. In this paper we will present an elegant solution based on current conveyor (CCII) for driving memristor as excitatory or inhibitory synapses following the neural network implementation.
A model of neurovascular coupling and the BOLD response: PART I

Abstract The mechanisms with which neurons communicate with the vasculature to increase blood flow, termed neurovascular coupling is still unclear primarily due to the complex interactions between many parameters and the difficulty in accessing, monitoring and measuring them in the highly heterogeneous brain. Hence a solid theoretical framework based on existing experimental knowledge is necessary to study the relation between neural activity, the associated vasoactive factors released and their effects on the vasculature. Such a framework should also be related to experimental data so that it can be validated against repetitive experiments and generate verifiable hypothesis. We have developed a mathematical model which describes a signaling mechanism of neurovascular coupling with a model of pyramidal neuron and its corresponding fMRI BOLD response. In the first part of two papers we describe the integration of the neurovascular coupling unit extended to include a complex neuron model, which includes the important Na/K ATPase pump, with a model that provides a BOLD signal taking its input from the cerebral blood flow and the metabolic rate of oxygen consumption. We show that this produces a viable signal in terms of initial dip, positive and negative BOLD signals.
Effective System Construction for Datacenter with Uses Multiple Batch System

The system administrator have to understand what kinds of job should be accomplished in own data center or own system. Specially, in the field of fundamental science, to collaboration between computer science and theoretical experiment is most important thing with shift of science research paradigm. In the case of datacenter where supports fundamental science, there are several batch systems to execute own job. That means there are several batch systems in whole system. In this case, some problems are occurred what system admin have to understand operation of whole batch systems and keep those systems in good working order. In this paper, in the data center to using several batch systems, it represent how we can use the whole computing resources in a data center as integrated batch systems.
Exponential Stability and Transfer Functions of Processes Governed by Symmetric Hyperbolic Systems

In this paper we study the frequency and time domain behaviour of a heat exchanger network system. The system is governed by hyperbolic partial differential equations. Both the control operator and the observation operator are unbounded but admissible. Using the theory of symmetric hyperbolic systems, we prove exponential stability of the underlying semigroup for the heat exchanger network. Applying the recent theory of well-posed infinite-dimensional linear systems, we prove that the system is regular and derive various properties of its transfer functions, which are potentially useful for controller design. Our results remain valid for a wide class of processes governed by symmetric hyperbolic systems.
Benefits of using ranking skip-gram techniques for opinion mining approaches

This paper presents an opinion mining approach in the domain of Social TV using two different contexts: Twitter user messages for Spanish and English, as well as movie reviews. The main goal of this paper is to study the benefits of opinion mining approaches using ranking skip-gram techniques for processing user feedbacks. To carry out this study it is described a system based on supervised machine learning and text categorisation techniques. This system has been evaluated on user messages obtained from Twitter and Amazon users' reviews. Results demonstrate that the use of ranking skip-grams techniques provide suitable opinion mining results independently of the language and scenario of application. The paper also presents information about business benefits of these technologies which are part of an advanced digital media delivery platform currently under development in the framework of the EU-funded project SAM - Socialising Around Media.
Active disturbance rejection robust control for uncertain systems with ill-defined relative degree

Active Disturbance Rejection (ADR) is a robust control paradigm which transforms the problem of controlling nonlinear systems by means of a direct active estimation. This estimation is further used to cancel the additive disturbances. This control design can be attained for some specific class of systems. Among others, if the system to be controlled is input-output linearizable (IOL), the tracking trajectories problem can be solved indeed. However, there are many examples where the system is not IOL in the whole space. The approximate IOL has been proposed to handle the control design for such class of systems that are usually known as ill-defined relative degree systems. This paper proposes the ADR based control on the adaptive estimation of the disturbance for ill-defined relative degree systems. An adaptive scheme was proposed for developing a state estimator of the uncertain system despite the poor knowledge of the plant and the presence of uncertainties. The adaptive observer uses a parametric identifier to obtain the time varying parameters required by the observer. Based on the states of the uncertain system, a switching feedback controller is able to reject actively the perturbations that affect the nonlinear system by a simple compensation scheme. The switch law for the controller was forced by the input-associated function that may cross zero when the relative degree is illdefined. This switching strategy is proposed to avoid the control singularities. A numerical example was developed for showing the observer/controller performance: The synchronization of the so-called unified chaotic system was proposed as testing problem. The obtained results in the example showed how the proposed adaptive disturbance rejection scheme can be implemented in uncertain systems.
Évaluation de la prescription de doxylamine dans le traitement des nausées et vomissements gravidiques : enquête auprès de 752 médecins généralistes

Contexte : Les nausees et vomissements gravidiques (NVG) sont tres frequents. Generalement presents au cours du premier trimestre, ils peuvent se prolonger tout au long de la grossesse. Rassurer les patientes et prodiguer des conseils hygieno-dietetiques suffit dans la plupart des cas mais le recours a une pharmacotherapie est parfois necessaire. Or, en France aucune classe d’anti emetique n’est approuvee par les autorites de sante en ce qui concerne la femme enceinte. La molecule ayant le profil le plus favorable dans la litterature est la doxylamine, recommandee en premiere intention dans le traitement specifique des NVG aux Etats Unis et au Canada. En France, elle est disponible avec pour unique indication mentionnee dans le RCP le traitement de l’insomnie occasionnelle de l’adulte. Objectifs : Nous avons mene une enquete afin d’evaluer la prescription de doxylamine par les medecins generalistes. Connaissent-ils cette molecule et cette indication ? Si oui, comment ? L’utilisent-ils en premiere intention ? Si non pourquoi ? Methode : 752 generalistes exercant en France ont repondu a un questionnaire semi directif envoye par email au printemps 2015. Resultats : 32,8 % seulement des repondants prescrivent la doxylamine. 21,5% en premiere intention apres echec des mesures hygieno-dietetiques. Les medecins femmes et les moins de 40 ans sont significativement plus nombreux a la prescrire. Les sources d’information les plus citees sont le site du CRAT et la Revue Prescrire. Les principaux freins a la prescription de doxylamine dans les NVG sont la meconnaissance de la molecule (22,5% des non prescripteurs) et/ou de cette indication (50%), l’absence d’AMM (21,5%) puis la crainte des effets secondaires pour la mere (12,5%) et pour l’enfant (9,5%). Conclusion : Malgre l’absence d’AMM, les conditions sont remplies pour justifier la prescription de doxylamine et eviter le risque juridique evoque par de nombreux medecins dans notre enquete. Avec une efficacite et une innocuite amplement demontrees dans la litterature et un important recul d’utilisation, la doxylamine devrait constituer le traitement medicamenteux de reference dans les NVG. Une information plus developpee aupres des prescripteurs qui lui preferent des molecules au profil moins avantageux semble necessaire.
Generalized network Voronoi diagrams: Concepts, computational methods, and applications

In the real world, there are many phenomena that occur on a network or alongside a network; for example, traffic accidents on highways and retail stores along streets in an urbanized area. In the literature, these phenomena are analysed under the assumption that distance is measured with Euclidean distance on a plane. This paper first examines this assumption and shows an empirical finding that Euclidean distance is significantly different from the shortest path distance in an urbanized area if the distance is less than 500 m. This implies that service areas in urbanized areas cannot be well represented by Voronoi diagrams defined on a plane with Euclidean distance, termed generalized planar Voronoi diagrams. To overcome this limitation, second, this paper formulates six types of Voronoi diagrams defined on a network, termed generalized network Voronoi diagrams, whose generators are given by points, sets of points, lines and polygons embedded in a network, and whose distances are given by inward/outward distances, and additively/multiplicatively weighted shortest path distances. Third, in comparison with the generalized planar Voronoi diagrams, the paper empirically shows that the generalized network Voronoi diagrams can more precisely represent the service areas in urbanized areas than the corresponding planar Voronoi diagrams. Fourth, because the computational methods for constructing the generalized planar Voronoi diagrams in the literature cannot be applied to constructing the generalized network Voronoi diagrams, the paper provides newly developed efficient algorithms using the ‘extended’ shortest path trees. Last, the paper develops user‐friendly tools (that are included in SANET, a toolbox for spatial analysis on a network) for executing these computational methods in a GIS environment.
Elimination of plasmid-linked polyglutamate production by Bacillus subtilis (natto) with acridine orange

Treatment of Bacillus subtilis (natto) strains Asahikawa, F, and M with acridine orange resulted in the conversion of approximately 64.2% of the Asahikawa population, 22.4% of the F population, and 9.2% of the M population to polyglutamate-nonproducing colonies. Such curing is suggestive of the involvement of plasmid DNA. Samples of cleared lysates of both parental and their cured strains were subjected to agarose gel electrophoresis to determine the plasmid composition. Parental strains were found to possess a plasmid, but polyglutamate-nonproducing derivatives were missing the plasmid. The plasmid-linked polyglutamate production, which was originally isolated from B. subtilis (natto), could be transformed in B. subtilis.
Autogenous Platelet-Rich Plasma in Combination With Bovine-Derived Hydroxyapatite Xenograft for Treatment of a Cystic Lesion of the Jaw

In the last 5 years, many studies about autogenous platelet-rich plasma have been undertaken pointing out its regenerative and reparative properties on tissues. The features of this product are an attribute of platelet cells, which, after cellular interactions, release growth factors. These molecules promote tissue healing and also induce cellular regeneration. Bone is a dynamic tissue subject to balanced processes of bony formation and reabsorption; autologous platelet gel or concentrate (PRP) can be used alone or in association with bony graft for the treatment of bony defect, cystic lesions, alveolar bone defects, and periodontal pockets. Its application fields are oral and maxillofacial surgery, plastic surgery, and general surgery, and it can be applied particularly in patients with coagulation diseases. In our experience, a giant cystic lesion of the jaw was treated with PRP and granules of bovine-derived hydroxyapatite xenograft to enhance bony regeneration and promote tissue healing.