Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards Sustainable Production of Protein-Rich Foods: Appraisal of Eight Crops for Western Europe. PART II: Analysis of the Technological Aspects of the Production Chain

ABSTRACT Increased production of plant protein is required to support the production of protein-rich foods which can replace meat in the human diet to reduce the strain that intensive animal husbandry poses on the environment. The suitability of lupin ( Lupinus spp.), pea ( Pisum sativum ), quinoa ( Chenopodium quinoa Willd.), triticale (x Triticosecale ), lucerne ( Medicago sativa ), grasses ( Lolium and Festuca spp.), rapeseed/canola ( Brassica napus ) and potato ( Solanum tuberosum ) for protein production in Western Europe was studied on the basis of a chain-approach. The technological aspects, which are considered in this paper, are the processing methods, and the functional and nutritional properties of the derived protein products. The overall evaluation of the technological prospects of the eight crops as a protein source for Western Europe leads to the conclusion that this part of the production chain is not decisive for that choice. Pea and lupin have a slight advantage over the other crops, because their concentrates and isolates are already commercially available.
Integrating and annotating the interactome using the MiMI plugin for cytoscape

UNLABELLED The MiMI molecular interaction repository integrates data from multiple sources, resolves interactions to standard gene names and symbols, links to annotation data from GO, MeSH and PubMed and normalizes the descriptions of interaction type. Here, we describe a Cytoscape plugin that retrieves interaction and annotation data from MiMI and links out to multiple data sources and tools. Community annotation of the interactome is supported. AVAILABILITY MiMI plugin v3.0. 1 can be installed from within Cytoscape 2.6 using the Cytoscape plugin manager in 'Network and Attribute I/0' category. The plugin is also preloaded when Cytoscape is launched using Java WebStart at http://mimi.ncibi. org by querying a gene and clicking 'View in MiMI Plugin for Cytoscape' link.
A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites

BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani.
Quantized phase code and receive filter synthesis in reverberating environment

In this paper, the problem of cognitively designing the transmit signal and the receive filter for a point-like target embedded in a high reverberating environment is addressed. Precisely, a dynamic environmental database on the actual scattering environment is assumed available. Then, an optimization procedure which sequentially improves the Signal to Interference plus Noise Ratio (SINR), exploiting the aforementioned information, is presented. A quantized phase-only condition, and a similarity constraint between the transmitted signal and a known radar waveform sharing a good ambiguity function, are enforced. The computational complexity of the proposed algorithm is linear with the number of iterations and polynomial with the receive filter length. At the analysis stage, the performances of the technique in the presence of a homogeneous clutter scenario are assessed.
Apolipoprotein A-II: a protein in search of a function.

OBJECTIVE To summarize current findings relevant to the function of apolipoprotein A-II (apoA-II), a major protein component of high density lipoproteins (HDL). STUDY SELECTION Studies relating to the structure, regulation and genetics of apoA-II are reviewed. These include studies of apoA-II expression in humans and mouse animal models. All studies cited were published between 1972 and 1993. CONCLUSIONS Since its discovery over 20 years ago, apoA-II has been a protein in search of a function. In fact, it has often been stated that apoA-II has no major function in plasma lipoprotein metabolism. While it is clear that apoA-II does not serve an essential function in HDL metabolism, the evidence overwhelmingly indicates that apoA-II importantly influences HDL functional states and suggests strongly that apoA-II is likely to contribute to atherogenesis.
An application of PER models to program extraction

Type theory allows us to extract from a constructive proof that a specification is satisfiable a program that satisfies the specification. Algorithms for optimization of such programs are currently the object of research. In this paper we consider one such algorithm, which was described in Beeson (1985) and which we will call ‘Harrop’. This algorithm greatly simplifies programs extracted from proofs in the Pure Construction Calculus. We use a Partial Equivalence Relation model for higher order lambda calculus, to check that t and Harrop(t) return the same outputs from the same inputs, i.e. that they are extensionally equal. As a corollary, we show that it is correct (and, of course, useful) to replace a program t with Harrop(t). Such a correctness result has already been proved by Möhring (Möhring 1989a, 1989b) using realizability semantics, but we obtain it as a corollary of a new result, the extensional equality between t and Harrop(t). Also the semantic method we use is interesting in its own right.
A framework for energy and transient power reduction during behavioral synthesis

In deep submicron and nanometer designs for battery driven portable applications, the minimization of total energy, average power, peak power, and peak power differential are equally important. In this paper, we propose a framework for simultaneous reduction of these energy and transient power components during behavioral synthesis. A new parameter called "Cycle Power Profile Function" (CPF) is defined which captures the transient power characteristics as a weighted sum of mean cycle power and mean cycle differential power. Minimizing this parameter using multiple voltages and dynamic clocking results in reduction of both energy and transient power. Based on the above, a datapath scheduling algorithm called "CPF-Scheduler" is developed which attempts to minimize the CPF. Experimental results show that for two voltage levels, three operating frequencies, switching activity of 0.5 and power profiling factor of 0.5, the scheduler achieves (i) total energy reductions in the range of 27 - 53%, (ii) average power reductions in the range of 40 - 73% (iii) peak power reductions in the range of 58 - 78% and (iv) peak power differential reductions in the range of 60 - 97%. Further, the impact of switching, profiling factor and resource constraints on the power profile is studied in detail.
Identification of thermostabilizing mutations for a membrane protein whose three‐dimensional structure is unknown

We recently developed a physics‐based method for identifying thermostabilizing mutations of a membrane protein. The method uses a free‐energy function F where the importance of translational entropy of hydrocarbon groups within the lipid bilayer is emphasized. All of the possible mutations can rapidly be examined. The method was illustrated for the adenosine A2a receptor (A2aR) whose three‐dimensional (3D) structure experimentally determined was utilized as the wild‐type structure. Nine single mutations and a double mutation predicted to be stabilizing or destabilizing were checked by referring to the experimental results: The success rate was remarkably high. In this work, we postulate that the 3D structure of A2aR is unknown. We construct candidate models for the 3D structure using the homology modeling and select the model giving the lowest value to the change in F on protein folding. The performance achieved is only slightly lower than that in the recent work. © 2016 Wiley Periodicals, Inc.
Characterization of Mucosal Disaccharidases from Human Intestine

In this study, we used a brush border membrane (BBM) preparation from human small intestine to analyze the proportion and the activity of major intestinal disaccharidases, including sucrase-isomaltase (SI), maltase-glucoamylase (MGAM) and lactase-phlorizin hydrolase (LPH). SI, MGAM and LPH respectively constituted 8.2%, 2.7% and 1.4% of total BBM protein. The activity of SI and LPH decreased threefold after purification from the brush border membrane, which highlights the effect of membrane microdomains on the functional capacity of these enzymes. All of the disaccharidases showed optimal activity at pH 6, over 50% residual activity between pH 5 to pH 7, and increasing activity with rising temperatures up to 45 °C, along with a stable functional structure. Therefore the enzymes can withstand mild intraluminal pH alterations with adequate function, and are able to increase their activity with elevated core body temperature. Our data provide a functional measure for characterization of intestinal disaccharidases under different physiological and pathological conditions.
Influence of Service Quality and Marketing Mix on Customer Satisfaction and Loyalty of Padma Resort Legian

Abstract-The hospitality industry in Legian and its surroundings is experiencing a rapid development. This results in a higher competition. Padma Resort Legian is one of the hotels that is able to well maintain customers based on comparison data with hotel competitors. This study aims to determine the effect of service quality and marketing mix on customer satisfaction and loyalty at Padma Resort Legian. Research respondents are customers from overseas with a minimum age is of 17 years staying at Padma Resort Legian. The number of respondents were 100 persons, covering male and female. Data were analysed using Partial Least Square analysis (PLS version 3). The result of the study shows that service quality has no significant effect on customer loyalty; service quality has no significant effect on customer satisfaction; marketing mix has significant effect on customer loyalty; marketing mix has significant effect on customer satisfaction; and satisfaction significantly influence customer loyalty. The implication of this research is Padma Resort Legian should pay attention to the indicators of marketing mix for satisfaction increase in order to increase customer loyalty, that is by locating the marketing mix in strategic location and comfortable, spacious and comfortable hotel room. Hotel interior gives psychological comfort to the guests; the ordering and payment process is done easily; the customer gets clear information from various sources, the hotel has skilled and competent employees who are able to provide good service to the customers and the price according to the quality is received by customers. Keywords: Customer Loyalty; Customer Satisfaction; Marketing Mix; Service Quality.
Diagnostic Potential of Parechovirus Capsid Proteins

ABSTRACT To study humoral and cellular immunity against human parechovirus type 1 (HPEV1), the viral capsid proteins VP0, VP1, and VP3 were expressed and purified as glutathione S-transferase (GST)-tagged recombinant proteins. The fusion proteins were used to raise antisera in rabbits. VP0 and VP1 antisera specifically detected HPEV1-infected cells in culture by immunoperoxidase staining and immunofluorescence. Furthermore, antisera against the VP0 and VP1 proteins had neutralizing effects against HPEV1 infection. When the HPEV1 antibody titers of 20 adults and 55 children were determined by a microneutralization test, the prevalence of HPEV1 antibodies in the adult population was 96%, while 50% of children were seropositive. Selected sera were used to evaluate HPEV1 fusion proteins as antigens in an enzyme immunoassay. The VP3 capsid protein appeared to be suitable for the purpose, with specificity of 100% and sensitivity of 96% compared to the neutralization test. Furthermore, T-cell responses to the purified HPEV1 and HPEV1 capsid fusion proteins were studied in 20 adults. Sixty percent of the subjects had T-cell proliferation responses to purified HPEV1, and 90% of the subjects also had positive T-cell responses to at least one of the GST capsid proteins.
The Effects of Corporate Financing Decisions on Firm Value in Bursa Malaysia

The primary objective of shareholders and financial managers is generally stated to be the maximization of shareholders’ wealth by increasing the firm value. This research was undertaken to investigate the effect of corporate financing decisions on firm value . The research has been carried out using the panel data procedure for a sample of 256 firms from 9 sectors listed on Bursa Malaysia during the period 2000-2015. The study uses Tobin’s Q representing firm value for the dependent variable. The corporate financing was measured by leverage (short-term debt to total assets, long-term debt to total assets, total debt to total assets and total debt to total equity) and debt maturity (long-term debt to total debt). Short-term debt to total assets and long-term debt to total assets has a positive significant relationship to firm value. This finding is consistent with the view that leverage and dividends mitigate agency costs of free cash flow problems, therefore, increasing firm value. Total debt to total assets affects firm value negatively. This proves that although there are benefits of debts, there is also the cost of debts. The cost of debt financing arises from the increase in the probability of bankruptcy. Firm value does not depend on the length of debt maturity.
Editorial: Dangers of steroid treatment in toxoplasmosis. Periocular injections and systemic therapy.

There is a general tendency among ophthalmologists to treat all forms of uveitis with corticosteroids. Patients with various inflammations of the uveal tract are usually treated with steroids first and investigated later. These patients are subjected to an investigation of the cause of their uveitis only when corticosteroids have failed to control their disease. Even when the cause of their uveitis is known or strongly suspected, such patients often fail to receive appropriate antimicrobial therapy during the period that their inflammatory responses are being suppressed by corticosteroids or by other immunosuppressive agents. The article by Nicholson and Wolchok in this issue of theArchivesillustrates the folly of such treatment programs. The patient described by them was the victim of some unknown lymphoproliferative disorder. She was treated with systemically administered corticosteroids for this disorder, and, while receiving this oral corticosteroid therapy, developed widespread paravascular inflammatory lesions of both retinae. Since
Company Characteristic Analysis on Implementation of Green Business in Food and Beverage’s Companies Listed in Indonesian Stock Exchange

Companies can do many business opportunities that drive the growth rate of the country’s economy. But on the other side of the rate of economic growth, visible social gap and environmental damage occurred. Therefore, the company must run its operations by not only focus on the interests of the company (shareholder), but also look at the social and environmental interests (stakeholder) by implementing green business which is the application of corporate social responsibility (CSR). This study aims to determine the effect of profitability, leverage, and growth on corporate social responsibility disclosure (CSRD) or disclosure of the implementation of green business of food and beverage companies listed on the Indonesia Stock Exchange (BEI) 2013 to 2015 which is the population of this study. This group of companies is taken as the object of research because in those years the group of companies continues to experience growth and contribute the largest to gross domestic product (GDP) compared to other groups of companies. This research can be input for many other companies how condition on CSRD in food and beverage condition seen from financial factors. The type of research is descriptive quantitative with hypothesis testing and causal method. The result of this research proves that profitability variable with return on assets (ROA) indicator influence significantly and positively to CSRD, while leverage and growth does not significantly influence CSRD.
The pitfall of antenatal thalassaemia screening

This was the first pregnancy of a non-consanguineous Thai couple. Antenatal screening revealed that the woman’s haemoglobin was 12.5 g/dl, MCV 82.2fL and mean cellular haemoglobin (MCH) 27.8 pg. Her husband’s haemoglobin was 15.4 g/dL, MCV 82.3fL and MCH 27.0 pg. Routine ultrasound at 21 weeks of gestation showed normal foetal anatomies. The amniotic fluid index was 20.9 cm. Because of the generous amniotic fluid volume at 21 weeks, she was scheduled to have a repeat ultrasound in two weeks. On ultrasound at 23 weeks, the amniotic fluid index was 27.5 cm and the foetus had cardiomegaly (cardiothoracic ratio 0.56). The foetal middle cerebral artery peak systolic velocity (MCA PSV) was 47 cm/s (corresponding to 1.6 multiples of median). Cordocentesis revealed that the foetal haemoglobin was 3.3 g/dL, MCV 122fL. Maternal Kleihauer test, autoimmune markers and viral studies, including that for Parvovirus B19, were all negative. Intrauterine foetal death was noted at 24 weeks. The post-mortem examination was unremarkable. Haemoglobin analysis (brilliant cresyl blue stain for HbH inclusion bodies and high performance liquid chromatography) was suggestive of HbE trait with co-existing alpha thalassaemia. Genotyping unveiled that she was in fact double heterozygous for Haemoglobin E and Haemoglobin Constant Spring (HbCS). Despite normal haemoglobin analysis, her husband was confirmed to be heterozygous for HbCS by genotyping. The foetus was homozygous for HbCS.
PDF shopping system with the lightweight currency protocol

A lightweight currency system is an Internet payment system. It is a business concept to serve transactions requiring small amounts of money. This project builds two prototype web systems to investigate the technical requirements which related to adoption of this payment methodology by online merchants. The two applications prototyped in this project are called PDF-Bookstore and E Bookstore. The PDF-Bookstore provides two services to users: it allows the users to hold and transact with a currency called Scart, and it allows the users to buy and sell PDF files with Scart currency. The E-Bookstore provides the buying and selling service for PDF documents using multiple lightweight currencies, one of them is currency' Scart. Scart currency are transacted in two ways by humans through a browser interface, and by systems through SOAP messaging.
Integration of EFQM excellence model and information systems criterion

Higher Education Institutions (HEIs) have become key institutions in the knowledge-based economy. Over the past decade, the Malaysian government has placed greater emphasis on improved efficiency and productivity in the HEI as an engine for promoting quality human capital for a knowledge-based economy. Importantly, the government raised the share of research and development in GDP from 1.5% in the Eighth Malaysia Plan (2000-2005) to 4.9% in the Ninth Malaysia Plan (2006-2010) for HEIs. As a result, there is a need to monitor the quality performance of HEIs to see if the governments objectives are being met. The European Foundation for Quality Management (EFQM) excellence model was introduced at the beginning of 1992 as the framework for assessing organizations for the European Quality Award. In fact, this model has been claimed to be the most widely used model of the national excellence awards in the European countries. However, it does not have Information Systems (IS) as a single criterion. The purpose of this paper is to evaluate the interrelationships between the EFQM excellence model and information systems criterion of Malcolm Baldrige National Quality Award (MBNQA) model in the HEIs of Malaysia. The paper identified ten (10) criteria from the research model: leadership; policy and strategy; people; partnership and resources; information systems; processes; people results; student results; society results and key performance results. We obtained 118 valid responses from person in charge of quality management in Malaysian HEIs. Structural equation model (SEM) is used to analyse the data and results indicate that the relationships among the research model followed the Information Systems-Quality Management theory and TQM theory.
An integrated analysis of plant and bacterial gene expression in symbiotic root nodules using laser-capture microdissection coupled to RNA sequencing.

Rhizobium-induced root nodules are specialized organs for symbiotic nitrogen fixation. Indeterminate-type nodules are formed from an apical meristem and exhibit a spatial zonation which corresponds to successive developmental stages. To get a dynamic and integrated view of plant and bacterial gene expression associated with nodule development, we used a sensitive and comprehensive approach based upon oriented high-depth RNA sequencing coupled to laser microdissection of nodule regions. This study, focused on the association between the model legume Medicago truncatula and its symbiont Sinorhizobium meliloti, led to the production of 942 million sequencing read pairs that were unambiguously mapped on plant and bacterial genomes. Bioinformatic and statistical analyses enabled in-depth comparison, at a whole-genome level, of gene expression in specific nodule zones. Previously characterized symbiotic genes displayed the expected spatial pattern of expression, thus validating the robustness of our approach. We illustrate the use of this resource by examining gene expression associated with three essential elements of nodule development, namely meristem activity, cell differentiation and selected signaling processes related to bacterial Nod factors and redox status. We found that transcription factor genes essential for the control of the root apical meristem were also expressed in the nodule meristem, while the plant mRNAs most enriched in nodules compared with roots were mostly associated with zones comprising both plant and bacterial partners. The data, accessible on a dedicated website, represent a rich resource for microbiologists and plant biologists to address a variety of questions of both fundamental and applied interest.
The Impact of Human Resource Management Practices and Leader Member Exchange on Job Performance: a moderating Role of Job Satisfaction in Jordanian Public Universities

Objectives: The purpose of the present study is to examine the relationship between Human resource practices, leader member exchange, job satisfaction and job performance in the public Jordanian universities, this study examine the moderating effects of job satisfaction on the relationship between human resource practices, leader member exchange and job performance. Methods/Statistical Analysis: The analysis was conducted using Structural Equation Model (SEM) to validate the research model and test the data. The final structural model that uses maximum likelihood estimation analysis confirmed goodness of fit to the data. Findings: The result of this study indicated that job satisfaction have significant(positive) moderating effect on the relationship between leader member exchange and job performance and insignificant (negative) moderating effect on the relationship between human resource practices and job performance. Improvements: This study contribute to the body of knowledge by providing empirical evidences to support theories and previous literature related to the moderating roles of job satisfaction in the relationship between human resource practices, leader member exchange and job performance. The present study concludes with research contributions and recommendations for further studies.