Miracle-dz/UniFAR-FTUs huggingface dataset:
Continuous-Wave Sub-THz Photonic Generation With Ultra-Narrow Linewidth, Ultra-High Resolution, Full Frequency Range Coverage and High Long-Term Frequency Stability

We report on a photonic system for generation of high quality continuous-wave (CW) sub-THz signals. The system consists on a gain-switching-based optical frequency comb generator (GS-OFCG), a two-optical-modes selection mechanism and a n-i-pn-i-p superlattice photomixer. As mode selection mechanism, both selective tunable optical filtering using Fabry-Pérot tunable filters (FPTFs) and Optical Injection Locking (OIL) are evaluated. The performance of the reported system surpasses in orders of magnitude the performance of any commercially available optical mm-wave and sub-THz generation system in a great number of parameters. It matches and even overcomes those of the best commercially available electronic THz generation systems. The performance parameters featured by our system are: linewidth <;10 Hz at 120 GHz, complete frequency range coverage (60-140 GHz) with a resolution in the order of 0.1 Hz at 120 GHz (10-12 of generated frequency), high long term frequency stability (5 Hz deviation over one hour). Most of these values are limited by the measurement instrumentation accuracy and resolution, thus the actual values of the system could be better than the reported ones. The frequency can be extended straightforwardly up to 1 THz extending the OFCG frequency span. This system is compact, robust, reliable, offers a very high performance, especially suited for sub-THz photonic local oscillators and high resolution spectroscopy.
The Autonomy of Foreign Subsidiaries: Environmental and National Influences

Some recent studies of Japanese direct investments abroad, have stressed the differences between the Japanese, the American and European models of organizational behavior [1]. These studies imply that the relationships between foreign subsidiaries of multinational firms and their parent corporations of diverse nationalities, particularly with respect to decision making autonomy, depend to a large extent on the corporate culture and management structure of the parent firms. On the other hand, other surveys have failed to discover significant behavioral differences between multinational corporations of diverse nationalities. One of the objectives of the present study is to document these discrepancies. It will by hypothesized that in spite of superficial differences, there are deep-seated similarities between multinational firms, whatever their country of origin: they will react to the same basic stimuli, though to a different extent and sometimes in different ways. In order to test these propositions, two different studies were conducted, one in Mexico with the local affiliates of US multinational corporations and the other in the United States with the American affiliates of foreign multinationals.
Effects of priming on behavior in virtual environments

Our project used a virtual environment called DarkCon to simulate a military reconnaissance mission. In this study, we investigated the differential effects of priming on a group of 64 civilians. Half were given a military-style, and half a game-style instructional video and briefing. We tested subjects for simulatorsickness, immersive tendencies, self-reported degree of presence, and recall of scenario elements. Psychophysiological data (skinconductance response and heartrate) was also recorded for each subject. We hypothesized that the priming condition would result in different behaviour within the virtual environment, differences in physiological response, and possibly differences within subjects' recall of their experience. Implications of our findings and directions for future research are discussed. CR Categories J4.1 Computer Applications Psychology I.6. 6 Simulation Output Analysis Additional
ANALISIS KARAKTERISTIK, KINERJA DAN PERSISTENSI REKSA DANA SAHAM DI INDONESIA - ANALYSIS OF CHARACTERISTICS, PERFORMANCE AND PERSISTENCY OF EQUITY MUTUAL FUNDS IN INDONESIA

The performance of actively managed mutual fund is largely dependent upon the investment decision of the fund managers amongst the other factors. This study examines the determinants of equity mutual fund performance in one of the emerging markets (Indonesia), with an emphasis on the factor of ability of investment manager. This study offers new insights into the Indonesian mutual fund industry. The results regarding the determinants examined (characteristics: total risk, systematic risk, fund age, size, ,stock selection, market timing and expenses ratio) show significant relation between total risk, fund age, stock selection, market timing, and fund performance. While no significant relation found between systematic risk, fund size, and the equity fund performance. For the common investor who wanted to invest in Mutual Funds in an emerging market like Indonesia's market during the period 1/ 1/ 2008 - 31/ 3/ 2011, the selection criteria that could had provided the best results in selecting the fund were: fund with low total risk, old fund, no timing ability for manager, stock selection ability, and low expenses ratio. In contrast, size of the fund and its systematic risk appeared to be statistically irrelevant in this study. This study also finds that there is no persistency of equity fund performance in Indonesia. The result of characteristics, persistency and equity fund performance in an emerging market clearly warrant future studies.
OBSERVATIONS ON THE SPREAD OF ASIATIC SCHISTOSOMIASIS *

Frou 1852, when Bilharz announced the discovery of Distomum hacmatobintn, down to 1904 no progress was made in the elucidation of the etiology of schistosomiasis. In 1904 tho London School of Tropical Medicine pub lished as Cragg's Prize Essay an account by ciatto of a new form of schistosomiasis in a Chinaman. Catto's disease was almost immediately shown to-* occur in the cat and dog. It then became possible for the first time to study in small susceptible animals the mode of infection with a human form of schistosomiasis. Native tradition and the deductions of local practitioners had given rise in South Africa to the view that i4fection was acquired when bathing. Looss, failing to find an intermediate host, and noting that the newly hatched embryo is killed in 1 in 1,000 dilution of hydrochloric acid, adopted the hypothesis that the infection took place through the skin, adding that the infective agent is the miracidium and that the meta morphosis into a cercarial form probably takes place in the liver. In 1911 Matsuura and Yamamoto showed that in animals experimentally infected with Schistosoma japoni cum by exposure in water from infected rice fields short ciliated larvae occurred in the skin.
Evaluation of Serum Creatine Kinase Muscle-Brain Fraction (CK-MB) and Lactate Dehydrogenase (LDH) as Markers of Perinatal Asphyxia in Term Neonates

Aim and Objectives: Perinatal asphyxia contributes significantly to neonatal morbidity and mortality. This study was conducted to compare the serum levels of creatine kinase muscle-brain fraction (CK-MB) and lactate dehydrogenase (LDH) among asphyxiated and non asphyxiated term neonates and to ascertain whether these enzymes can identify asphyxiated neonates who will be at high risk for hypoxic ischemic encephalopathy and multi-organ dysfunction. Material and Methods: Prospective observational study. A study was conducted on 50 neonates comprising the cases and 50 neonates comprising the controls meeting the inclusion and exclusion criteria. The blood samples for CK-MB and LDH was drawn at 8±2 and 72±2 hours of age respectively and sent for analysis. A serum CK-MB value >92.6 U/L at 8 hours and LDH value >580 U/L at 72 hours was taken as the cut-off level. Results: The cut-off CK-MB value of >92.6 U/L has 28% sensitivity with a specificity of 100%. CK-MB has a positive predictive value of 100% with a negative predictive value of 58.14%. The cut-off LDH value of >580 U/L has 59.18% sensitivity with a specificity of 92%. LDH has a positive predictive value of 87.88% with a negative predictive value of 69.70%. Conclusion: Estimation of CK-MB at 8 hours of life and LDH at 72 hours of life can help distinguish an asphyxiated from a nonasphyxiated term neonate in correlation with history and clinical features in the neonate.
Some preliminary evidence on employee share ownership schemes in New Zealand listed companies

This note examines employee share ownership schemes as approved by the Commissioner of the Inland Revenue Departnzenr under the provistons of section 166 of the 1976 Income Tax Act. The note provides preliminary evidence on the characteristics of these section 166 schemes, including an analysis of the participation rates and the benefits conferred.
The analysis of the process of taking over companies based on the theory of games

The changes proceeding in Europe have caused the increase of takeovers recently. The European Union, globalization and competitiveness increase make the taking over process necessary for existence and development of companies. Of course, one cannot buy every number of shares without any limitations. Legalities are conformed to the Directive of the European Parliament 2004/25/WE. Nowadays, in Poland, there is a discussion about public offering act from 2005, especially the change of limit of obligatory offer is considered. In this work one tool of the theory of games is presented and used to analyze takeovers (the power index of Banzhaf). There is also a discussion about the limit of obligatory offer in chosen country of European Union. It is compared to Polish law and assessed with the use of tools of cooperative games. The solution based on the theory of games is proposed to solve the problem of the limit of obligatory offer.
Critical Success Factors of Management Style in Food Industry and Consumer Products Respond to Asian Economics Community

The study of Critical Success Factors of management style in food industry to Asian Economics Community was conducted to investigate the factors that affect to Thai food industrial in foreign countries especially in Asian Economics Countries. The relationship between business strategies and manufacturing concern with value chain activities, logistics and transportation activities, business partners relationship, government support and characteristics of entrepreneurs. The result found that the successful of Thai food industrial has high related work experiences at 0.74, value chain activities at 0.80 and logistic and transportation at 0.76. The analytical of value chain activities in term of inbound activities, operation activities, outbound activities and transportation has the high correlation level (r = 0.982, p-value
Analysis of glioma cell lines for amplification and overexpression of MDM2

Recently, amplification of the gene encoding a p53 binding protein, MDM2, was determined in 8% of the cases constituting a large series of glioblastomas. Here we have utilized Southern blot analysis to examine 30 cell lines established from such tumors, and our investigation has revealed large increases in MDM2 gene dosage in two cases, one of which showed coamplification of the CDK4 gene that resides in close proximity to MDM2 in chromosomal region 12q13–14. Northern analysis demonstrated overexpression of MDM2 mRNA in the two cell lines with gene amplification, and overexpression of MDM2 protein was evident in each of these by immunohistochemical and Western blot analysis. Analysis of TP53 cDNAs revealed normal TP53 sequences in the cell lines with MDM2 amplification; these results are consistent with those of previous studies suggesting that MDM2 amplification occurs only in tumors expressing wild‐type p53. In total, these data suggest that MDM2 amplification in glioblastoma cell lines occurs at a frequency (6.7%) comparable to that determined in primary tumors; occurs in cell lines expressing wild‐type p53; and can involve the coamplification of additional genes.
The ATP-Dependent Lon Protease of Salmonella enterica Serovar Typhimurium Regulates Invasion and Expression of Genes Carried on Salmonella Pathogenicity Island 1

ABSTRACT An early step in the pathogenesis of Salmonella enterica serovar Typhimurium infection is bacterial penetration of the intestinal epithelium. Penetration requires the expression of invasion genes found in Salmonella pathogenicity island 1 (SPI1). These genes are controlled in a complex manner by regulators in SPI1, including HilA and InvF, and those outside SPI1, such as two-component regulatory systems and small DNA-binding proteins. We report here that the expression of invasion genes and the invasive phenotype of S. enterica serovar Typhimurium are negatively regulated by the ATP-dependent Lon protease, which is known to be a major contributor to proteolysis in Escherichia coli. A disrupted mutant of lon was able to efficiently invade cultured epithelial cells and showed increased production and secretion of three identified SPI1 proteins, SipA, SipC, and SipD. The lon mutant also showed a dramatic enhancement in transcription of the SPI1 genes hilA, invF, sipA, and sipC. The increases ranged from 10-fold to almost 40-fold. It is well known that the expression of SPI1 genes is also regulated in response to several environmental conditions. We found that the disruption of lon does not abolish the repression of hilA and sipC expression by high-oxygen or low-osmolarity conditions, suggesting that Lon represses SPI1 gene expression by a regulatory pathway independent of these environmental signals. Since HilA is thought to function as a central regulator of SPI1 gene expression, it is speculated that Lon may regulate SPI1 gene expression by proteolysis of putative factors required for activation of hilA expression.
Mortality study of 18 000 patients treated with omeprazole

Background: The long term safety of potent gastric acid suppressive therapy has yet to be established. Method: General practice record review at a median interval of 26 months followed by retrieval of details of all deaths within four years using the UK National Health Service Central Registers in 17 936 patients prescribed omeprazole in 1993–1995. Death rates were compared with general population rates. Results: Records of 17 489 patients (97.5%) were examined. A total of 12 703 patients received further scripts for antisecretory drugs, 8097 for omeprazole only (65.6%): 3097 patients have died. All cause mortality was higher in the first year (observed/expected (O/E) 1.44 (95% confidence intervals (CI) 1.34–1.55); p<0.0001) but had fallen to population expectation by the fourth year. There were significant mortality increases in the first year, falling to or below population expectation by the fourth year, for deaths ascribed to neoplasms (1.82 (95% CI 1.58–2.08); p<0.0001), circulatory diseases (1.27 (95% CI 1.13–1.43); p<0.0001), and respiratory diseases (1.37 (95% CI 1.12–1.64); p<0.001). Increased mortality ascribed to digestive diseases (2.56 (95% CI 1.87–3.43); p<0.0001) persisted, although reduced. Increased mortality rates for cancers of the stomach (4.06 (95% CI 2.60–6.04); p<0.0001), colon and rectum (1.40 (95% CI 0.84–2.18); p=0.075), and trachea, bronchus, and lung (1.64 (95% CI 1.19–2.19); p<0.01) seen in the first year had disappeared by the fourth year but that for cancer of the oesophagus had not (O/E 7.35 (95% CI 5.20–10.09) (p<0.0001) in year 1; 2.88 (95% CI 1.62–4.79) (p<0.001) in year 4). Forty of 78 patients dying of oesophageal cancer had the disease present at registration. Twenty seven of those remaining cases had clinical evidence of Barrett’s disease, stricture, ulcer, or oesophagitis at registration (O/E 3.30 (95% CI 2.17–4.80)). Six deaths occurred in patients with hiatal hernia or reflux only (O/E 1.02 (95% CI 0.37–2.22)) and five in patients without oesophageal disease (O/E 0.77 (95% CI 0.25–1.80)). No relationships were detected with numbers of omeprazole scripts received. Conclusions: Increases in mortality associated with treatment are due to pre- existing illness, including pre-existing severe oesophageal disease. There was no evidence of an increased risk of oesophageal adenocarcinoma in those without oesophageal mucosal damage recorded at registration.
A new class of neurotoxin from wasp venom slows inactivation of sodium current

The effects of α‐pompilidotoxin (α‐PMTX), a new neurotoxin isolated from the venom of a solitary wasp, were studied on the neuromuscular synapses in lobster walking leg and the rat trigeminal ganglion (TG) neurons. Paired intracellular recordings from the presynaptic axon terminals and the innervating lobster leg muscles revealed that α‐PMTX induced long bursts of action potentials in the presynaptic axon, which resulted in facilitated excitatory and inhibitory synaptic transmission. The action of α‐PMTX was distinct from that of other known facilitatory presynaptic toxins, including sea anemone toxins and α‐scorpion toxins, which modify the fast inactivation of Na+ current. We further characterized the action of α‐PMTX on Na+ channels by whole‐cell recordings from rat trigeminal neurons. We found that α‐PMTX slowed the Na+ channels inactivation process without changing the peak current–voltage relationship or the activation time course of tetrodotoxin (TTX)‐sensitive Na+ currents, and that α‐PMTX had voltage‐dependent effects on the rate of recovery from Na+ current inactivation and deactivating tail currents. The results suggest that α‐PMTX slows or blocks conformational changes required for fast inactivation of the Na+ channels on the extracellular surface. The simple structure of α‐PMTX, consisting of 13 amino acids, would be advantageous for understanding the functional architecture of Na+ channel protein.
Genetic Testing for Myeloid Neoplasms and Leukemia Effective : October 1 , 2017

PLEASE NOTE: Contracts exclude from coverage, among other things, services or procedures that are considered investigational or cosmetic. Providers may bill members for services or procedures that are considered investigational or cosmetic. Providers are encouraged to inform members before rendering such services that the members are likely to be financially responsible for the cost of these services.
Impaired working memory and normal sustained attention in borderline personality disorder

Lazzaretti M, Morandotti N, Sala M, Isola M, Frangou S, De Vidovich G, Marraffini E, Gambini F, Barale F, Zappoli F, Caverzasi E, Brambilla P. Impaired working memory and normal sustained attention in borderline personality disorder. Objective: Although reports in the literature describe deficits in working memory in borderline personality disorder (BPD), the evidence is limited and inconsistent. The aim of this study was to evaluate further this cognitive dimension and its clinical correlates in BPD. Method: We compared the performance of 15 BPD patients to 1:1 matched healthy controls on verbal working memory as determined by the sequential letter N-back test and sustained attention as measured using the continuous performance test (CPT). Results: BPD patients performed significantly worse on the N-back test compared to healthy controls (p < 0.05), but not on the CPT. The N-back deficit was more pronounced and significant in the 3-back condition and inversely correlated with impulsivity. Conclusions: These results suggest the presence of working memory deficits in BPD that may be linked to greater impulsivity and sustained by impairment in the dorsolateral prefrontal cortex.
Approaches to Organizational Structure and Effectiveness: A Study of Selected Textiles Units in Punjab

Two perspectives have mainly dominated the analysis of organizational structure. The consensual perspective as reflected in Max Weber's legal-rational model of bureaucracy is posited on the absence of conflict in the organizations. As opposed to this is the perspective that emphasises the inevitability of conflict. The first model of organizational analysis emphasises interdependence and coordination of the organization's structural components to main tain its stability. This perspective lays stress upon bureaucratic rationality and its relationship with organizational efficacy. Weber in developing his model of bureaucracy highlights three major dimensions of bureaucratization, viz., presence of a distinctly defined hierarchy, a high degree of division of labour based upon specializa tion and employment of a centralized procedure of decision making (Weber, 1947; Bendix, 1960). He holds that such a bureaucratic system ensures coordination within the organization because it genera tes a tendency towards normative legitimacy. Subordinates follow orders simply because they believe that their superiors are technically more competent and have a legitimate right to give orders. That is, they believe that power allocation is based on competence (Weber, 1946). There is consensus over values in the organization. The model does not leave any scope for conflict, incompatibility and hostility within the organization. Hence in their absence, there will be organizational efficacy. As opposed to the above view, scholars such as Gouldner (1947), Bendix (1947) and Metcalfe (1975) stress upon conflict and politics w i t h i n t h e o r g a n i z a t i o n . T h e y h o l d t h a t t h e s t r u c t u r e o f the organization is dominated by a struggle for power and resources.
Thrombotic risk factors: Basic pathophysiology

Although venous thrombosis has been traditionally associated with stasis and hypercoagulability, arterial thrombosis is mainly associated with heightened platelet reactivity and damage to the vessel wall. Accordingly, classic risk factors for venous and arterial thrombosis are usually considered distinct. Those for the former include cancer, surgery, pregnancy, and estrogens use, whereas risk factors of arterial thrombosis include smoking, hypertension, diabetes, the metabolic syndrome, and hyperlipidemia. However, a number of studies have recently challenged this dichotomy, and it is now recognized that venous and arterial thromboses share several risk factors, suggesting a closer link between the two clinical conditions. Typical examples of shared risk factors are age and the metabolic syndrome. This review addresses the mechanism whereby established risk factors increase the risk of venous or arterial thrombosis, or both.
InGaAs-AlAs-AlAsSb coupled quantum well intersubband transition all-optical switch with low switching energy for OTDM systems

We report a novel intersubband transition all-optical switch with low switching energy using InGaAs-AlAs-AlAsSb coupled double quantum wells (C-DQWs) with AlAs spacer layers. Very low saturation energy density of 34 fJ//spl mu/m/sup 2/ was observed for bulk transmittance with wavelength of 1.62 /spl mu/m. Using a waveguide, whose core is 93 periods of the C-DQWs, an all optical switch with a low switching energy of 10 pJ for 10-dB extinction ratio was realized.