Miracle-dz/UniFAR-FTUs huggingface dataset:
Hormonal control of sexual behaviour in the female rabbit.

Hormonal control of sexual behavior in the female rabbit are reviewed. Data from field studies on natural populations together with laboratory studies are discussed in terms of neural and hormonal control of copulatory behavior. Rabbits were studied since the female belongs to the group of mammals which exhibit "reflex ovulation" (ovulation only occurs following copulation). The main concern in this paper is with the requirements and control of events which lead up to occurrence of receptivity in the female. Receptivity in normal females during pregnancy during lactation and during pseudopregnancy as well as the hormonal basis for changes in receptivity are discussed. The effects of ovariectomy on pre- and postpubertal rabbits and the effects of gonadal steroids (estrogens progestins androgens) in ovarectomized rabbits are reviewed. Studies of neural substrate for mating and mounting behavior localization of neural structures and nonspecific factors are included.
Analysis and Design of a Single-stage AC-DC Front-end Resonant Converter with a New Active Control Technique

By means of a new active control scheme, the full - bridge series parallel resonant converter is employed to create a novel single-stage high power factor correction (SSHPFC) converter. The current driven property of the series-parallel resonant tank alleviated the need of the bulky input inductance. Together with the high frequency operation of the resonant converter, it allows a compact size converter. The self-sustained phase shift modulation (SSPSM) controller is modified to give an active current control scheme for the power factor correction applications. The design procedure for a 600 W converter is given in detail. Analytical, simulation, and experimental results are given to provide the proof of concept.
Ambulatory blood pressure measurements in mid-pregnancy and development of hypertensive pregnancy disorders

Objective: To explore if blood pressure (BP) readings over 24 h is a useful addition to uterine artery Doppler to screen for hypertensive disorders. Methods: In a prospective observational study, we invited nulliparous women with abnormal and normal uterine artery Doppler but normal BP at the time of their routine anomaly scan. BP was measured by the woman using automated apparatus at five specified time intervals over 24 h at 22–24 weeks. Pregnancy outcome was retrieved from delivery suite records, discharge summaries, and letters to general practitioners if necessary. Logistic regression was used to explore the contribution of uterine artery Doppler and BP measurements towards the development of pre-eclampsia. Results: Data were available from 52 women with abnormal and 48 women with normal uterine artery Doppler. Thirteen women developed hypertension in pregnancy. Significant difference was found in the BP of women who did or did not develop hypertensive disorders. BP recordings showed the diurnal variation. Both uterine artery Doppler mean PI and BP showed significant correlation with future development of hypertension. Conclusions: Women can self-measure BP at home. BP readings show diurnal variation. There are significant differences in BP of women who do and do not develop hypertension later in the pregnancy. Use of home BP monitoring over 24 h of the day in mid-pregnancy is unlikely to add to the use of uterine artery Doppler and a one-off BP reading for future development of hypertension in pregnancy.
Antiepileptic drug-induced bone loss in young male patients who have seizures.

BACKGROUND Long-term antiepileptic drug (AED) therapy is a known risk factor for bone loss and fractures. Vitamin D deficiency is frequently cited as a cause for bone loss in patients who have seizures. OBJECTIVE To determine whether men who have seizures, but who are otherwise healthy, suffer substantial bone loss in the hip while taking AEDs. PATIENTS AND METHODS We prospectively examined femoral neck bone mineral density (BMD) by dual-energy x-ray absorptiometry in 81 consecutive men, aged between 25 and 54 years old (mean age, 45 years), who were attending an outpatient seizure clinic. Low BMD values were analyzed for known risk factors for bone loss. Dual-energy x-ray absorptiometry scans were repeated in 54 patients, 12 to 29 months later (mean, 19 months), to assess the rate of change in BMD over time. RESULTS Multivariate linear regression analysis revealed that age (P<.001) and time receiving AEDs (P<.003) were the 2 important risk factors associated with low femoral neck BMD. Neither vitamin D deficiency, hypogonadism, cigarette smoking, nor excess alcohol intake were associated with low BMD after correcting for age and time on AEDs. Longitudinal analysis of femoral neck BMD revealed that only those in the youngest age group (25-44 years) showed significant declines in femoral neck BMD (1.8% annualized loss; 95% confidence interval, -3.1 to -0.9; P<.003) while receiving AED therapy. There was no evidence that a specific type of AED was more causally related to bone loss in this group although most patients were taking phenytoin sodium or carbamazepine during the longitudinal assessment. CONCLUSIONS Long-term AED therapy in young male patients who have seizures causes significant bone loss at the hip in the absence of vitamin D deficiency. Dual-energy x-ray absorptiometry scanning of the hip is useful in identifying patients who are particularly susceptible to rapid bone loss while taking AEDs.
A Key Agonist-induced Conformational Change in the Cannabinoid Receptor CB1 Is Blocked by the Allosteric Ligand Org 27569*

Background: The cannabinoid receptor CB1 has been refractory to purification and structural analysis, thus limiting mechanistic information about its activation and attenuation. Results: Fluorescence probes on purified, functional CB1 detect a key agonist-induced structural change that is blocked by a novel allosteric ligand. Conclusion: Some allosteric GPCR ligands may capture structural intermediates. Significance: GPCR intermediate structures may be optimal templates for allosteric drug design. Allosteric ligands that modulate how G protein-coupled receptors respond to traditional orthosteric drugs are an exciting and rapidly expanding field of pharmacology. An allosteric ligand for the cannabinoid receptor CB1, Org 27569, exhibits an intriguing effect; it increases agonist binding, yet blocks agonist-induced CB1 signaling. Here we explored the mechanism behind this behavior, using a site-directed fluorescence labeling approach. Our results show that Org 27569 blocks conformational changes in CB1 that accompany G protein binding and/or activation, and thus inhibit formation of a fully active CB1 structure. The underlying mechanism behind this behavior is that simultaneous binding of Org 27569 produces a unique agonist-bound conformation, one that may resemble an intermediate structure formed on the pathway to full receptor activation.
Kinetochore composition and its function: lessons from yeasts.

Proper chromosome segregation during cell division is essential for proliferation, and this is facilitated by kinetochores, large protein complexes assembled on the centromeric region of the chromosomes. Although the sequences of centromeric DNA differ totally among organisms, many components of the kinetochores assembled on centromeres are very well conserved among eukaryotes. To define the identity of centromeres, centromere protein A (CENP-A), which is homologous to canonical histone H3, acts as a landmark for kinetochore assembly. Kinetochores mediate spindle–microtubule attachment and control the movement of chromosomes during mitosis and meiosis. To conduct faithful chromosome segregation, kinetochore assembly and microtubule attachment are elaborately regulated. Here we review the current understanding of the composition, assembly, functions and regulation of kinetochores revealed mainly through studies on fission and budding yeasts. Moreover, because recent cumulative evidence suggests the importance of the regulation of the orientation of kinetochore–microtubule attachment, which differs distinctly between mitosis and meiosis, we focus especially on the molecular mechanisms underlying this regulation.
Effective nutrition labels for fast food consumers

Purpose The fast-food market is one area which faces little regulation of visible nutritional information on menus and food packaging to encourage healthy food choices. Additionally, nutritional information’s effectiveness is mostly unknown in the fast-food market. The purpose of this paper is to provide insights into the effectiveness of various forms of nutritional labelling methods and information by analysing the consumer decision-making process of 248 fast-food consumers. Design/methodology/approach Three discrete choice experiments are used to compare three popular nutritional symbol methods. Consumer preferences for these symbols are extracted using a “choice-based” conjoint analysis, while controlling for price and branding of fast-food products. Findings It is found that a very simple “traffic light signal” is the best signal for suggesting healthiness, with as much as 41 per cent of the importance in consumer decision making (p<0.01), over that of product pricing and even product brand and performs better than more information laden guided daily amounts symbols and health endorsement methods (attributing 27 and 13 per cent in their respective studies). This highlights the fine balance between too much and too little food nutrition information and (most notably) how specific nutritional information methods can be even more influential on food choices than a change in product price might. Originality/value There is currently a lack of research into the use of nutritional cues on influencing fast-food choices. Additionally, most previous studies focus on the isolated effect of nutrition labels.
ANALISIS STRUKTUR KEPEMILIKAN TERHADAP DISCRETIOARY ACCRUAL THE ANALYSIS OF OWNERSHIP STRUCTURE ON DISCRETIONARY ACCRUAL

This study aims to empirically prove the ownership structure of domestic and foreign as well as a tendency towards concentrated ownership structure manipulation of financial reporting information. La Porta, et al. (2006) explains that the strong or weak investor protection associated with the legal order that is followed by the country concerned. Indonesia and countries in Asia in general character is the structure of corporate ownership is concentrated, so the problem of differences in the primary interest is the divergence of interests between the controlling owner of the company with the majority as a minority owner. The sample of this study is a company listed on the Stock Exchange period from 2004 to 2010. Elections were conducted with a purposive sample. The structure of ownership in this study were measured with the first proxy largest percentage ownership of public companies by domestic and foreign institutions, in this study are referred to foreign institutions are foreign companies operating in Indonesia. Each ownership group is divided into majority and minority ownership group. Discretionary accruals (DTAC) is calculated with a modified Jones model (Dechow, et al., 1995). The results of this study is that there are differences in discretionary accruals of companies owned by domestic institutions and companies owned by foreign institutions. There are differences in discretionary accrual of the largest property company that first  50% and the first largest holdings  50%. Thus the results of this study have implications that in order to protect the rights of minorities, the regulators limit the percentage of single ownership of the largest first, so that ownership of minorities are protected. KeyWord: Ownership Structure, Earnings Management
Movement Awareness-Adaptive Spatio Temporal Noise Reduction in Video

SUMMARY In this letter, we present an e ﬃ cient video matching-based denoising method. Two main issues are addressed in this paper: the matched points and the denoising algorithm based on an adaptive spatial temporal ﬁlter. Unlike previous algorithms, our method adaptively selects reference pixels within spatially and temporally neighboring frames. Our method uses more information about matched pixels on neighboring frames than other methods. Therefore, the proposal enhanced the accuracy of video denoising. Simulation results show that the proposed method produces cleaner and sharper images. key words: denoising, video matching, ASTA, bilateral ﬁlter
An Overview of Social Media for Marketing

Due to an environment that is social media driven, it is very important for small businesses to understand how to utilize social media sites such as Facebook, Instagram, Twitter, etc. Unfortunately, this is not the case as small businesses do not have a strategy in place when they start using social media. This paper reviews the literature regarding social media utilized for marketing purposes, and identifies strategies which increase sales. This approach considers social media and its importance, advantages and disadvantages, applications, customer engagement, small business, effect, procedure, and how marketing is applied to small business.
Mastocytosis – an update

Mastocytosis (MC) encompasses a range of disorders characterized by a clonal, pathological accumulation of mast cells having a somatic activating mutation of the tyrosine kinase receptor Kit (exon 17, codon 816; D816V) in more than 90 % of adult patients. The mutation is much less common in children. Skin and bone marrow are most often affected. Symptoms and clinical course are very heterogeneous due to a variable degree of local or systemic mediator release or organ dysfunction as a result of mast cell infiltrates. Pruritus, wheals, flushing and gastrointestinal symptoms are often reported. The majority of pediatric patients experience spontaneous remission of MC. Adults usually have chronic disease, rarely transforming into an aggressive or lethal type. Indolent systemic MC with involvement of skin and bone is the most common type. In MC the risk for anaphylactic reactions following an insect sting (and other causes of mast cell activation) is increased significantly. Diagnostic hallmarks are biopsies from skin and bone marrow using tryptase antibodies for staining as well as serum tryptase levels. At present a curative treatment for MC is not available. Systemic histamine H1 receptor antagonists are widely used. Aggressive types of MC respond partially to IFN‐α or cladribine. A variety of receptor tyrosine kinase inhibitors is still under critical evaluation for systemic treatment of MC. After introduction of the WHO classification for MC and the development a German MC guideline, as well as the foundation of national and international competence networks for MC, a significantly improved quality of medical care for MC patients can be expected for the future.
Business Analytics and Big Data: Driving Organizational Change

Big Data Analytics has changed the way organizations make decisions, manage business processes, and create new products and services. Business analytics is the use of data, information technology, statistical analysis, and quantitative methods and models to support organizational decision making and problem solving. The main categories of business analytics are descriptive analytics, predictive analytics, and prescriptive analytics. Big Data is data that exceeds the processing capacity of conventional database systems and is typically defined by three dimensions known as the Three V’s: Volume, Variety, and Velocity. Big Data brings big challenges. Big Data not only has influenced the analytics that are utilized but also has affected technologies and the people who use them. At the same time Big Data brings challenges, it presents opportunities. Those who embrace Big Data and effective Big Data Analytics as a business imperative can gain competitive advantage.
Households in the smart grid: existing knowledge and new approaches

Citation for published version (APA): Christensen, T. H. , Gram-Hanssen, K. , & Friis, F. (2013). Households in the smart grid: existing knowledge and new approaches. In L. Hansson, U. Holmberg, & H. Brembeck (Eds.), Making Sense of Consumption: Selections from the 2nd Nordic Conference on Consumer Research 2012 (pp. 333-348). Centre for Consumer Science, University of Gothenburg. https://gupea.ub. gu.se/handle/2077/34508
Effects of deposition temperature on Parylene-C properties

This paper reports the study of in-situ deposition temperature (ranging from 20°C to 80°C) effects on Parylene-C properties in terms of glass transition temperature (Tg), β-relaxation temperature (Tβ), Young's modulus and crystallinity (including crystallite size). The results show that the Parylene-C (PA-C) thin film deposited at higher deposition temperature exhibits higher Tg and Tβ, revealing that the movement of the molecular backbones is further frozen and restricted. It is physically consistent with the data showing that higher deposition temperature induces greater degree of crystallinity and larger Young's modulus. With the new knowledge, Parylene-C thin film with properties tailored to various requirements could be achieved by choosing the proper deposition temperature.
Membrane Localization of Cyclic Nucleotide Phosphodiesterase 3 (PDE3)

Subcellular localization of cyclic nucleotide phosphodiesterases (PDEs) may be important in compartmentalization of cAMP/cGMP signaling responses. In 3T3-L1 adipocytes, mouse (M) PDE3B was associated with the endoplasmic reticulum (ER) as indicated by its immunofluorescent colocalization with the ER protein BiP and subcellular fractionation studies. In transfected NIH 3006 or COS-7 cells, recombinant wild-type PDE3A and PDE3B isoforms were both found almost exclusively in the ER. The N-terminal portion of PDE3 can be arbitrarily divided into region 1 (aa 1–300), which contains a large hydrophobic domain with six predicted transmembrane helices, followed by region 2 (aa 301–500) containing a smaller hydrophobic domain (of ∼50 aa). To investigate the role of regions 1 and 2 in membrane association, we examined the subcellular localization of a series of catalytically active, Flag-tagged N-terminal-truncated human (H) PDE3A and MPDE3B recombinants, as well as a series of fragments from regions 1 and 2 of MPDE3B synthesized as enhanced green fluorescent (EGFP) fusion proteins in COS-7 cells. In COS-7 cells, the localization of a mutant HPDE3A, lacking the first 189 amino acids (aa) and therefore four of the six predicted transmembrane helices (H3A-Δ189), was virtually identical to that of the wild type. M3B-Δ302 (lacking region 1) and H3A-Δ397 (lacking region 1 as well as part of region 2) retained, to different degrees, the ability to associate with membranes, albeit less efficiently than H3A-Δ189. Proteins that lacked both regions 1 and 2, H3A-Δ510 and M3B-Δ604, did not associate with membranes. Consistent with these findings, region 1 EGFP-MPDE3B fusion proteins colocalized with the ER, whereas region 2 EGFP fusion proteins were diffusely distributed. Thus, some portion of the N-terminal hydrophobic domain in region 1 plus a second domain in region 2 are important for efficient membrane association/targeting of PDE3.
Relative risk and economic consequences of inpatient care among patients with renal failure.

During the final phases of chronic renal disease, inpatient care comprises an enormous share of morbidity and direct medical costs. Using an attributable risk methodology, this study calculated inpatient resource utilization and associated costs for chronic renal failure (CRF) and ESRD. A national hospital survey was used to identify the 348,962 hospitalizations for patients with renal failure in 1991. Among persons under the age of 65, pre-ESRD CRF patients had the same number of hospitalizations (nearly 75,000) as ESRD patients. Age-adjusted relative risk calculations indicate that patients with renal failure experience greater inpatient morbidity compared with other populations with chronic, progressive diseases. For example, compared with persons with diabetes, ischemic heart disease, hypertension, and emphysema, renal patients were at significantly higher risk of hospitalization for congestive heart failure, pneumonia, sepsis, electrolyte disorders, and gastrointestinal hemorrhage. Overall, renal failure patients were ten times more likely to be hospitalized (relative risk, 10.0; 95% confidence interval, 10.00 to 10.04) and, on average, were hospitalized nearly 1 day longer (P < 0.01) compared with the non-renal failure population in 1991. As a result, the economic consequences of inpatient care for the treatment of renal failure were enormous. In 1991, 222,827 hospitalizations, 1.5 million days of inpatient care, and $2.2 billion were attributable to renal failure. Further studies that examine other components of direct medical costs (e.g., long-term care, outpatient care, and pharmaceuticals) as well as indirect costs associated with the treatment and care of renal failure patients are warranted.
Molecular basis of methylmalonyl‐CoA mutase apoenzyme defect in 40 European patients affected by mut° and mut– forms of methylmalonic acidemia: Identification of 29 novel mutations in the MUT gene

Methylmalonyl‐CoA mutase (MCM) apoenzyme deficiency is a rare metabolic disease that may result in distinct biochemical phenotypes of methylmalonic acidemia (MMA), namely mut° and mut–. We analyzed a cohort of 40 MCM‐deficient patients with MMA affected by either the mut° or the mut– form of the disease. By direct sequencing of cDNA and gDNA of the MUT gene, we detected 42 mutations, 29 of which were novel mutations. These included five frameshift mutations (insertion, deletion, or duplication of a single nucleotide), five sequence modifications in consensus splice sites, six nonsense and 12 missense mutations, and a large genomic deletion including exon 12. We explored how the 12 novel missense mutations might cause the observed phenotype by mapping them onto a three‐dimensional model of the human MCM generated by homology with the P. shermanii enzyme. In this work we update the spectrum of MCM mutations (n=84), and then discuss their prevalence and distribution throughout the coding sequence in relation to the enzyme structure. Hum Mutat 25:167–176, 2005. © 2005 Wiley‐Liss, Inc.
Spatial Organization of Myxococcus xanthus during Fruiting Body Formation

ABSTRACT Microcinematography was used to examine fruiting body development of Myxococcus xanthus. Wild-type cells progress through three distinct phases: a quiescent phase with some motility but little aggregation (0 to 8 h), a period of vigorous motility leading to raised fruiting bodies (8 to 16 h), and a period of maturation during which sporulation is initiated (16 to 48 h). Fruiting bodies are extended vertically in a series of tiers, each involving the addition of a cell monolayer on top of the uppermost layer. A pilA (MXAN_5783) mutant produced less extracellular matrix material and thus allowed closer examination of tiered aggregate formation. A csgA (MXAN_1294) mutant exhibited no quiescent phase, aberrant aggregation in phase 2, and disintegration of the fruiting bodies in the third phase.
Atypical Microsporum canis variant in an immunosuppressed child

A 10‐year old boy with X‐chromosomal adrenoleukodystrophy presented with scaly patches on the scalp and diffuse effluvium. He was on immunosuppressive therapy because of a chronic graft‐versus‐host‐reaction after allogenic bone marrow transplantation. At home he had been in contact with cats, rabbits and guinea pigs. Through Wood light and KOH examination, we confirmed the diagnosis of tinea capitis and started antimycotic therapy.