Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of histone methyltransferase RE-IIBP target genes in leukemia cell line

Abstract Histone methylation has diverse functions including transcriptional regulation via its lysine or arginine residue methylation. Studies indicate that deregulation of histone methylation is linked to human cancers including leukemia. Histone H3K27 methyltrnasferase response element II binding protein (RE-IIBP), as a transcriptional repressor to target gene IL-5, interacts with HDAC and is over-expressed in leukemia patient samples. In this study, we have identified that hematopoiesis-related genes GATA1 and HOXA9 are down-regulated by RE-IIBP in K562 and 293T cells. Transient reporter analysis revealed that GATA1 transcription was repressed by RE-IIBP. On the other hand, HOXA9 and PBX-related homeobox gene MEIS1 was up-regulated by RE-IIBP. These results suggest that RE-IIBP might have a role in hematopoiesis or leukemogenesis by regulating the transcription of target genes, possibly via its H3K27 methyltransferase activity.
AAC Bailey hard red spring wheat

DePauw, R. M. , Knox, R. E. , Cuthbert, R. D. , Singh, A. K. and McCaig, T. N. 2014. AAC Bailey hard red spring wheat. Can. J. Plant Sci. 94: 175–181. AAC Bailey hard red spring wheat (Triticum aestivum L.) had grain yield within the range of the checks with maturity significantly earlier than the mean of the checks. The quantity of protein of AAC Bailey was significantly less than Lillian but gluten strength was stronger than Lillian as measured by farinograph. AAC Bailey is eligible for grades of Canada Western Red Spring. AAC Bailey expressed resistance to prevalent races of leaf rust and stem rust, moderate resistance to common bunt, and moderate susceptibility to loose smut. AAC Bailey frequently had lower fusarium head blight disease index and lower deoxynivalenol concentration than Lillian and Laura.
Dry-cured ham Kraški pršut seasoning losses as affected by PRKAG3 and CAST polymorphisms

Association between polymorphisms on PRKAG3 (Ile199Val) and CAST (Lys249Arg and Ser638Arg) genes and dry ham seasoning losses was studied. A total of 724 green hams (same pig crossbreed, same pig producer) were selected, genotyped (PCR-RFLP) and processed according to the rules of consortium for dry-cured ham Kraški pršut. Weight losses after each processing phase were recorded. We observed significant effect of interaction between gene polymorphism and dry ham producer on seasoning losses, indicating that the effect of studied genes differ in relation to manufacturing practice or product type, despite narrow consortium constraints. The analysis was thus made separately for each producer; in case of producer B, PRKAG3 affected salting, resting and overall losses (Val/Val higher than Ile/Ile or Ile/Val) but in case of producer A, the effect of PRKAG3 was significant only for salting losses (Ile/Val lower than Ile/Ile or Val/Val). Effects of CAST polymorphisms were significant only in case of producer A; CAST249 Arg/Arg hams showed the highest first salting, drying, and overall seasoning losses, whereas CAST638 Arg/Arg hams had the highest drying, ripening, and overall seasoning losses. In conclusion, PRKAG3 and CAST polymorphisms were associated with seasoning losses, important from economic viewpoint, but also for salt intake and product quality.
Imagining Jihad

The article examines how the Islamic State (IS) has evolved into a community- and initial state-building project. Using Benedict Anderson’s concept of “imagined community” (Anderson, B. [1983]. Imagined communities. London: Verso), we claim that IS is about to construct an aggressive Sunni national identity with a specific territorial claim, which could have a high impact on international order. Comparing nationalism and Islamism allows us to understand the strong appeal of the latter much better than a focus on religion alone.
Influence of water quantity on the yield, water use efficiency, and plant water relations of Leucaena leucocephala in arid and semi arid environment using drip irrigation system

Water is considered an important factor in the arid and semi-arid areas because water shortage affects the agricultural production. The current study aimed to investigate the influence of water application level on the dry matter yield, water use efficiency (WUE), and plant water status in Leucaena leucocephala. The treatments consisted of five levels of water applications based on actual evapotranspiration (AET): 0.25, 0.50, 0.75, 1.00 and 1.25 AET respectively. The production was increased from 306.4, 676.3, 724.1, 838.5, to 1172.7 kg/ha as the water application levels increased. The estimated WUE was 2.32, 2.57, 1.83, 1.59 and 1.78 kg/ha/mm for 0.25, 0.50, 0.75, 1.00 and 1.25 AET, respectively. Increasing the water application level did not increase the WUE. Using the irrigation level at 0.50 AET can be used to irrigate Leucaena crop without leaving any significant change in dry matter yield compared with 0.75 and 1.00 AET, respectively. There was no significant effect of water application level on each of the leaf water potential (Ψw) and leaf relative water content (LRWC). The means of Ψw was -2.3, -2.1, -2.2, -2.3, -2.2 MPa at 0.25, 0.50, 0.75, 1.00 and 1.25 AET, respectively. The means of leaf relative water content were 75, 74, 77, 77 and 78% at the water treatment levels, respectively. Under different water application levels, a poor correlation between the Ψw and LRWC existed. It is recommended to use 50% of AET as the best irrigation water management treatment for Leucaena production.
Coelomycetous fungi in several forest ecosystems of black sea provinces of Turkey.

Hyphomycetous specimens were collected in forest ecosystems of the middle and east Black Sea coastal region. Sixty-nine taxa in 50 genera were recorded on various substrates including 20 plant families. Sporidesmium, Pseudospiropes, Passalora, Periconia, Ramularia, Helminthosporium, Taeniolella, Monodictys, Bispora, Chalara, Trichothecium, Tubercularia and Volutella were the common fungal genera. Fagaceae, Betulaceae, Buxaceae, Ulmaceae and Pinaceae are common host plant families.
Unwanted attention: The psychological impact of cyberstalking on its survivors

This exploratory study investigated experiences of cyberstalking by analysing the psychological impact on young adult users (n = 12; females = 9). The participants completed in-depth e-mail interviews documenting their lived experiences as cyberstalking survivors. The data were thematically analysed. The findings indicate that young adults who have experienced cyberstalking report a wide-ranging psychological impact on them; including feelings of stress, hurt, paranoia, insomnia, betrayal, anger, fear, and in some cases even depression. These findings advocate the need for tailored interventions to alleviate the impact on cyberstalking survivors.
Accompanying Greg on the Journey Through Grief: A Case Study Exploring the Psycho-Spiritual Support and Care of a Young Man With Down Syndrome in the Aftermath of Traumatic Loss

In this documented case study, with its thick descriptions, the author explores and discusses her relationship with Greg, a young man with Down Syndrome, as he journeys through grief. In writing of her spiritual care, the author describes how she works with Greg, helping him to process his emotions, to develop new connections, and to move on and live in his grief. In return, Greg offered her guidance, gifting her with his presence, authenticity and an exuberant love of life.
Large Mammalian Herbivores and the Conservation of Arid Acacia Stands in the Middle East

Abstract: High mortality and poor recruitment in Acacia tree populations in many parts of the Middle East may result in loss of biodiversity. Human activities in recent decades have caused drastic changes in the water regime and the abundance of wild and domestic ungulates, which may negatively affect these trees. We studied the effects of large mammalian herbivores on the establishment of young Acacia raddiana and A. tortilis in the Arava Valley between the Red Sea and the Dead Sea, Israel. Seed accumulation under trees was high when large herbivores were excluded, and direct observations confirmed that ungulates were the main seed dispersers of these Acacia species. Insect seed predators (bruchid beetles) damaged more than 95% of seeds not consumed by ungulates. Seed germination was facilitated by gut passage through ungulates. Seedling survival was determined largely by water availability and was independent of herbivore density. Under present conditions, several years of high rainfall are necessary for successful establishment of young trees. Under severe browsing pressure by ungulates, growth in juvenile trees was delayed and smaller sizes were overrepresented. There was no evidence, however, of effects on the long‐term demography of Acacia trees, perhaps because ungulates increased seedling densities by enhancing the viability and germination of seeds. We conclude that large mammalian herbivores are essential components of arid Acacia savannas and that wild and domestic ungulates must be included in future conservation plans.
The Effects of Two Different Dosages of BCAA Supplementation on A Serum Indicators of Muscle Damage in Wrestlers

ABSTRACT Background and Aim: Few studies have been done to examine the effect of different dosages of branched-chain amino acid (BCAA) supplementation on muscle damage indices in wrestlers. The purpose of this research was to compare the effects of two dosages of BCAA on muscle damage indices after heavy resistance exercise in wrestlers. Methods: 29 young wrestlers were randomly selected and divided into three groups. All subjects participated in heavy weight resistance exercise (3 sets, 10 repetitions, 80% 1RM). The BCAA was given at doses of 210 and 450 mgkg −1 body weight for supplemental groups 1 and 2 respectively, 30 minutes before and after the exercise test and dextrin was given at a dose of 210 mg.kg−1 body weight for the placebo group. To identify enzyme activity (IU/L), venous blood samples were obtained 30 min prior to exercise and at 24 and 48 hrs post exercise. Data were statistically analyzed using ANOVA with repeated measures and the Bonfferoni test (P≥ 0. 05). Results: Based on this study results, creatine kinase (CK), lactate dehydrogenase (LDH), creatine kinase isoenzyme MB (CKMB) activity were significantly increased (p<0.05) in all groups. CK, LDH, CKMB indices having the highest activity in the placebo group, but there were no significant differences between all groups. Conclusion: These results provide evidence that the use of two different dosages of BCAA did not decrease the muscle damage associated with heavy resistance exercise.
Tomato pomace and safflower meal as ingredients in non-feed-removal molt diets

SUMMARY In California, where more than 90% of processed tomatoes in the United States are produced and 50% of the US production of safflower seeds is grown, there is an abundance of tomato pomace, a by-product of tomato processing, and safflower meal from decorticated safflower seeds. Diets with these 2 ingredients may produce molt and postmolt results comparable with a recommended no-added-salt non-feed-removal diet. Therefore, molt and postmolt measurements were compared in third-cycle Single Comb White Leghorn hens fed non-feed-removal diets containing 1) corn and soybean meal (CS8, control), 2) corn meal with no added salt (C-NS), 3) C-NS and safflower meal (C-NS-SM), 4) or C-NS and tomato pomace (C-NS-TP). During the molt, birds fed C-NS-TP consumed amounts of feed comparable with those of birds fed the other test diets; however, birds fed tomato pomace had lower BW and observably more diarrhea than other birds. Mortality did not differ among birds fed the treatment diets during the molt and postmolt periods. No differences were observed among treatment groups for postmolt BW, mortality, specific gravity of eggs, and eggshell thickness. Postmolt egg production was different among treatment groups, ranked as CS8 > C-NS > C-NS-SM > C-NS-TP. After molting, hens fed the C-NS-SM and C-NS-TP diets produced lower egg weights than did hens fed the CS8 and C-NS diets. The Haugh units for eggs from hens fed the C-NS, C-NS-SM, and C-NS-TP diets were higher than those for eggs from hens fed the CS8 diet. Overall, feeding safflower meal yielded results for feed consumption and BW comparable with those of feeding the no-salt diet during molt. However, except for egg production, postmolt measurements were equivalent among the C-NS, C-NS-SM, and C-NS-TP diets. We conclude that tomato pomace is useful in non-feed-removal molt diets.
CELLULAR CARDIOMYOPLASTY BASED ON MUSCLE STEM CELLS: IMPLICATIONS FOR THERAPY

Heart disease is the leading cause of death in the world and cellular cardiomyoplasty is an emerging therapeutic option to repair damaged myocardium. Muscle-derived stem cells (MDSCs) have been shown to have an improved regenerative capacity in bone, cartilage, and skeletal muscle when compared to myoblasts. After implantation into ischemic hearts, MDSCs display high levels of engraftment, induce neoangiogenesis, prevent cardiac remodeling, and elicit significant improvements in cardiac function. Notably, diversity in MDSC behavior has been associated with innate sex-related differences in skeletal muscle, bone, and cartilage. These results suggest that differences in inherent stem cell characteristics, including sex and age, could account for some of the outcome variability noted in clinical trials. Therefore we examined the effect of sex-related differences of MDSCs in cardiac repair. Transplantation of both cell sexes significantly improved cardiac function in comparison to saline. We also found that with increasing age, the proliferation and differentiation abilities of MDSCs decreased while their survival under stress conditions and vascular endothelial growth factor (VEGF) secretion remained unchanged. Our in vivo study demonstrates that the age of MDSCs does not impact their regenerative capacity but increasing the age of the host leads to decreased repair, which implies that the majority of age-related decreases in repair are due to changes in the microenvironment. We then examined methods to improve the efficacy of cell transplantation via preconditioning strategies. We first investigated the effects of mechanical stimulation on increasing the secretion of VEGF, which plays a major role in effecting cardiac repair after cell transplantation. Mechanical preconditioning significantly increased VEGF secretion, angiogenesis, and cardiac function after myocardial infarction, suggesting that this method of cell preconditioning could increase therapeutic efficacy. Another major issue with cell therapy is low cell survival after implantation. We hypothesized that increasing the level of antioxidants in MDSCs prior to transplantation could increase survival and therefore improve functional cardiac repair. We found that antioxidant pretreatment increased cell survival, cardiac function, and angiogenesis, and decreased scar formation. These pretreatment strategies have the potential to significantly improve the efficacy of cell transplantation and enhance the outcomes of heart disease patients.
Nitrous oxide in 2010: who will have the last laugh? (Part 3)

In the  rst two parts of this series, the basic science of nitrous oxide (N2O) was reviewed and some of its claimed risks and bene ts were analysed. In this, the third and  nal instalment, the remaining risks and bene ts will be assessed and the alternatives to nitrous oxide will be evaluated. It will be shown that many of the claimed adverse effects of nitrous oxide either do not exist or are overstated. Nitrous oxide is a versatile agent with many potential bene ts during all phases of anaesthesia.
Heroin Dependence Recovery

The consequences of heroin dependence can be extremely difficult to escape from, resulting in unpleasant and potentially terrifying experiences. This descriptive study explores the factors which are important in achieving abstinence, in allowing recovery to be maintained in the longer term, and in potentially allowing an eventual exit from heroin dependence, from the experiences and suggestions of 40 long-term voluntarily abstinent heroin dependents. Findings revealed that behaviour modification and the promotion of recovery occurred mostly through interventions, producing a range of positive effects that facilitated natural recovery processes. Clear support was obtained for the ‘maturing out’ hypothesis of heroin dependence.
Towards a plurilingual development paradigm: from spontaneous to informed use of translation in additional language learning

This paper explores the role played by translation in additional language learning (ALL) as a particular example of translation in other learning contexts (TOLC), i.e. translation as used in educational contexts other than translation studies. The project presented in this paper draws on research and good practice in translation studies, pedagogy, educational psychology and language acquisition and is framed within a plurilingual development paradigm. The theoretical framework questions a monolingual approach to ALL and considers educational objectives, learning strategies, translation competence, multi-competence, the Dynamic Model of Multilingualism, plurilingualism and the Interdependence Hypothesis to favour the connected development of linguistic and mediation skills. The pedagogy adopts a humanistic approach to teaching, teaching for transfer and (socio)constructivism. The paper reports on the second of an ongoing three-stage study involving 45 undergraduate students. In the first stage, the spontaneous use of translation was recorded to identify critical instances of its use in ALL. In the second, data regarding the teacher’s and students’ perceptions and uses of translation were gathered. Following on from the findings of this research, learning material is currently being designed with a view to including translation in additional language learning in an explicit way.
Blood levels of a-tocopherol in a disorder of

Batten's disease is characterized by the onset of progressive mental regression and seizures. The brain cells of patients with this disease show the accumulation of large masses of a lipopigment, ceroid. Similar accumulations have been observed in the brain of a genetic strain of English setters. Previous studies by our laboratory have established that the accumulated lipopigment, ceroid, is clearly different from "age" pigment, or lipofuscin, in a number of parameters, although some similarities exist between the two lipopigments. Zeman and others have proposed that this group of disorders is the result of a massive peroxidation of essential fatty acids with the accumulation of large masses of lipid polymers in the form of lipopigments. Since the proposed biological role of cw-tocopherol is that of an antioxidant, this compound has been utilized in experimental therapeutic approaches with patients affected with Batten's disease. At this time, the standard treatment for this group of disorders is the administration of a mixture of vitamin E, ascorbic acid, methionine, and butylated hydroxylated toluene as originally proposed by Tappel. Patients on this therapeutic regimen have shown some improvement. Our approach to this problem was to investigate the blood and tissue levels of o-tocopherol in this disorder. Early studies suggested that blood cs-tocopherol levels were below normal values. However, a study on a large number of samples from both human patients and dogs with a similar disease clearly established that blood and tissue levels of a-tocopherol are significantly higher than normal age-matched controls. Obviously this "peroxidative disorder" progresses in spite of an ample supply of the biological antioxidant, a-tocopherol. If c�-tocopheroI is a significant factor in the inhibition of peroxidative damage, then a-tocopherol may not act exclusively as an antioxidant as has been proposed by a number of investigators. Am.J. C'lin.Nutr. 27: 1152-1157, 1974.
Guest Editorial

Studies show that the weakest link in a security chain is human (Crossler et al., 2013; Curry, 2011; Vroom & von Solms, 2004). Although organizations adopt numerous security technologies and solutions to protect their systems from security threats, that’s still not adequate (Rhodes, 2001). The success of organizational security depends on the compliance of security policy of their employees who play an essential role in the prevention and detection of security incidents. Getting people to comply with security policy and practice good security behavior is not always easy since people have different levels of security knowledge and motivations, and often exhibit different security behavior and attitudes when they use technologies (Davinson & Sillence, 2010). People often do not actively comply with information security policies and procedures. This kind of behavior places the organizations’ assets and business in danger (Pahnila, Siponena, & Mahmood, 2007; Stanton et al., 2005). As web applications increase in volume and complexity in the recent years, malicious content and cyber attacks are rapidly increasing in both their frequency and their sophistication (Alazab et al., 2013; Steinke, Tundrea, & Kelly, 2011). For many organizations, it is unrealistic to bar the use of web applications such as Facebook, Twitter, Blogs, and LinkedIn by employees, because many employees (such as marketing staff and real estate professionals) need to utilize these sites for work-related activities. The recent solicitation for the National Science Foundation (NSF) Secure and Trustworthy Cyberspace (SaTC) program recognizes the importance of human behavior when designing, building, and using cyber security technology. Studies show that incorporating an understanding of human behavior into cyber security products and processes can lead to more effective technology (Pfleeger & Caputo, 2012). With the rapid development of emerging technologies such as web 2.0, social media, mobile technology, virtual environment, online role-playing games,
Variation in Calf Body Mass in Migratory Caribou: The Role of Habitat, Climate, and Movements

Abstract Individual differences in body mass exert a major influence on several life-history traits of mammals. We investigated the factors influencing variation in body mass of calves of migratory caribou (Rangifer tarandus) at birth (June, 19 years of data) and in autumn (October, 15 years of data) in the Rivière-aux-Feuilles (Feuilles, 1991–2003) herd and the Rivière-George (George, 1978–2003) herd in Québec and Labrador, Canada. Mass at birth (hereafter, birth mass) did not differ between herds, possibly because part of their winter ranges overlapped. However, Feuilles calves were smaller in autumn than George calves, possibly reflecting differences in summer ranges. The birth mass of calves also varied with year, likely as the outcome of both intrinsic and extrinsic factors. Birth and autumn body mass were influenced positively by habitat quality in June, estimated by the normalized difference vegetation index. The North Atlantic Oscillation of the previous winter was positively correlated with autumn mass of the George calves. Previous winter snowfall was negatively related to the mass of George calves, and daily movement rates in summer were negatively correlated with the mass of calves of both herds in autumn. Birth mass was positively related with productivity in October in the George herd and also with productivity 3 and 4 years later, which corresponds to the beginning of reproduction of females. We suggest that a mechanism of delayed quality effect of the calves could have been involved in the decrease of fall productivity and population size of the George herd.