Miracle-dz/UniFAR-FTUs huggingface dataset:
Can Tax Rate Increases Foster Investment Under Entry and Exit Flexibility? - Insights from an Economic Experiment

It is well-known that taxes affect risky investment decisions. Analytical studies indicate that tax rate increases can foster (accelerate) investment if there is flexibility, in particular when an exit option is available. We design an experiment that is based on an analytical model with binomial random walk and entry and exit flexibility. Contrasting the underlying model, we find accelerated investment, which is often considered as an increased willingness to invest, on tax rate increases to be independent of the existence of an exit option. However, we observe this investor reaction only for a tax increase, not for a tax decrease. This investment behavior is driven possibly by tax salience and the mechanisms known from the theory of irreversible choice under uncertainty. Our empirical evidence suggests that the accelerating tax effects are much more common than is predicted by the theoretical literature. Policy makers should therefore carefully consider the behavioral aspects when anticipating taxpayer reactions.
Patient-centered medical home cost reductions limited to complex patients.

OBJECTIVES To examine the long-term relationships between costs, utilization, and patient-centered medical home (PCMH) clinical practice systems. STUDY DESIGN Clinical practice systems were evaluated at baseline by the Physician Practice Connections-Research Survey (PPC-RS). Annual costs and utilization of a retrospectively constructed cohort of 58,391 persons receiving primary care at 1 of 22 medical groups over a 5-year period (2005-2009) were compared. METHODS Multivariate regressions adjusting for patient demographics, health status, and autoregressive errors compared PPC-RS scores and study outcomes for the entire cohort and 3 subcohorts defined by medical complexity (medication count 0-2 [n = 29,657], 2-6 [n = 19,505], >7 [n = 9229]). Outcomes (adjusted to 2005 dollars) were total costs, outpatient costs, inpatient costs, inpatient days, and emergency department (ED) use. RESULTS For the entire cohort, a 10% increase in PPC-RS scores was associated with 3.9 (medication count: 0-2), 6 (3-6), and 11.6 (>7) fewer ED visits per 1000 in 2005; and 5.1, 7.6, and 13.6 fewer ED visits in 2009. That 10% increase was not associated with the 0-2 medication subcohort's total (-$22/person in 2005; $184/person in 2009), outpatient (-$11/person in 2005; $42/person in 2009), or inpatient ($26/person in 2005; $29/person in 2009) costs. However, it was associated with significantly decreased total (-$446/person in 2005; -$184/person in 2009) and outpatient (-$241/person in 2005; -$54/person in 2009) costs for the most medically complex subcohort (>7 medications). CONCLUSIONS Association of PCMH clinical practice systems with reduced costs appears limited to the most medically complex patients.
Processor Energy Characterization for Compiler-Assisted Software Energy Reduction

Energy consumption is a fundamental barrier in taking full advantage of today and future semiconductor manufacturing technologies. The paper presents our recent research activities and results on characterizing and reducing the energy consumption in embedded systems. Firstly, a technique for characterizing the energy consumption of embedded processors during an application execution is presented. The technique trains a per-processor linear approximation model for fitting it to the energy consumption of the processor obtained by postlayout simulation. Secondly, based on the energy model mentioned above, the paper shows techniques for reducing the energy consumption by optimally mapping program code, stack frames, and data items to the scratch-pad memory (SPM) of the processor memory space.
Assessing the ecological niche and invasion potential of the Asian giant hornet

The Asian giant hornet (Vespa mandarinia) was recently detected in western British Columbia, Canada and Washington State, United States. V. mandarinia are an invasion concern due to their ability to kill honey bees and affect humans. Here, we used habitat suitability models and dispersal simulations to assess potential invasive spread of V. mandarinia. We show V. mandarinia are most likely to establish in areas with warm to cool annual mean temperature, high precipitation, and high human activity. The realized niche of introduced populations is small compared to native populations, suggesting introduced populations could spread into habitats across a broader range of environmental conditions. Dispersal simulations also show that V. mandarinia could rapidly spread throughout western North America without containment. Given its potential negative impacts and capacity for spread, extensive monitoring and eradication efforts throughout western North America are warranted.
Global proteomic profiling of native outer membrane vesicles derived from Escherichia coli

Gram‐negative bacteria constitutively secrete native outer membrane vesicles (OMVs) into the extracellular milieu. Although recent progress in this area has revealed that OMVs are essential for bacterial survival and pathogenesis, the mechanism of vesicle formation and the biological roles of OMVs have not been clearly defined. Using a proteomics approach, we identified 141 protein components of Escherichia coli‐derived native OMVs with high confidence; two separate analyses yielded identifications of 104 and 117 proteins, respectively, with 80 proteins overlapping between the two trials. In the group of identified proteins, the outer membrane proteins were highly enriched, whereas inner membrane proteins were lacking, suggesting that a specific sorting mechanism for vesicular proteins exists. We also identified proteins involved in vesicle formation, the removal of toxic compounds and attacking phage, and the elimination of competing organisms, as well as those involved in facilitating the transfer of genetic material and protein to other bacteria, targeting host cells, and modulating host immune responses. This study provides a global view of native bacterial OMVs. This information will help us not only to elucidate the biogenesis and functions of OMV from nonpathogenic and pathogenic bacteria but also to develop vaccines and antibiotics effective against pathogenic strains.
Binge-eating disorder as a distinct familial phenotype in obese individuals.

CONTEXT Binge-eating disorder (BED)-a syndrome that only recently has attracted scientific attention-is often seen in obese individuals, especially those with severe obesity. However, it remains unclear whether BED represents an etiologically distinct behavioral phenotype of obesity or simply a nonspecific eating pattern sometimes seen in obese individuals. OBJECTIVE To test whether BED aggregates in families independently of obesity, and if so, whether familial factors for BED also independently increase the risk of obesity. DESIGN, PATIENTS, AND SETTING Blinded family interview study of overweight or obese probands with (n = 150) and without (n = 150) BED, and their first-degree relatives (n = 888) in a community setting evaluated between October 2002 and July 2004. MAIN OUTCOME MEASURES Lifetime diagnosis of BED; current and highest lifetime body mass index (calculated as the weight in kilograms divided by the square of the height in meters). RESULTS Binge-eating disorder aggregated strongly in families independently of obesity (odds ratio, 2.2; 95% confidence interval, 1.4-3.6; P<.001). Furthermore, relatives of probands with BED displayed a markedly higher prevalence of severe obesity in adulthood (body mass index >/=40) than relatives of probands without BED even when controlling for proband body mass index (odds ratio, 2.5; 95% confidence interval, 1.4-4.4; P = .002). CONCLUSIONS Binge-eating disorder is a familial disorder caused in part by factors distinct from other familial factors for obesity. Furthermore, these BED-specific familial factors may independently increase the risk of obesity, especially severe obesity. It follows that targeted interventions capable of preventing or treating traits influenced by these BED-specific familial factors could reduce the public health burden of obesity.
III. Endocrine cell recognition of luminal nutrients.

The profile of hormone secretion from the gastrointestinal tract on food ingestion depends to a great extent on the composition of the meal. High levels of protein result in a quantitatively and qualitatively different response compared with a meal rich in fats. The outstanding question is whether this differential response is driven by the ability of gastroenteric endocrine cells to directly sense the contents of the lumen via apical microvilli. Alternative effectors would include activation of the intrinsic and extrinsic innervation or other epithelial cell populations. The data available indicate that the role of the gastrointestinal innervation is relatively limited and is probably a major factor only in the postprandial responses of hormones released from endocrine cells in the distal small intestine. However, whether nutrients directly stimulate gastroenteric endocrine cells or another epithelial cell type has yet to be established.
The Application of "Renal Pedicle Rotation" Method in Retroperitoneal Laparoscopic Partial Nephrectomy for Renal Ventral Tumors.

OBJECTIVES To present preliminary experience of "renal pedicle rotation" method in retroperitoneal laparoscopic partial nephrectomy (RLPN) for renal ventral tumors. METHODS A retrospective analysis of renal surgery database about patients undergoing RLPN was conducted. We identified 14 consecutive cases of all the surgeries from December 2013 to October 2014 with renal ventral tumors. The 14 surgeries were all in the application of renal pedicle rotation method, an intraoperative skill in which surgeons rotates the kidney on renal pedicle axis after separating renal artery and vein for a better tumor exposure. RESULTS A total of 14 patients underwent RLPN. All surgeries were successful without conversion to radical nephrectomy or open partial nephrectomy. The mean operative time was 171.1±47.2 min (range 83-246), the mean warm ischemia time was 15.9±9.8 min (range 7-35) and the mean estimated blood loss was 89.3±102.2 mL (range 10-300). Mean postoperative hospital stay was 6.2±1.9 days (range 4-10) and mean retroperitoneal drainage was 4.2±1.4 days (range 2-8). No intraoperative complications occurred. Postoperative complications developed in four patients. All patients had negative margins and pathological examination revealed 10 (71.4%) clear cell carcinomas, two (14.2%) epithelial renal angiomyolipoma, one (7.1%) papillary carcinoma and one (7.1%) nephrotuberculosis. The review of the early oncologic outcomes revealed no local recurrence and distant metastasis. CONCLUSION The renal pedicle rotation method might be a feasible and safe procedure to get a better tumor exposure for incision and suture in renal ventral tumors RLPN surgeries with acceptable postoperative outcomes.
The Intersections between Early Feminist Polemic and Publishing: How Books Changed Lives in the Second Wave

Abstract Kate Millett's Sexual Politics and Germaine Greer's The Female Eunuch were two of the foundation texts of second wave feminism – certainly, they generated the greatest amount of attention, the greatest number of headlines. Literary criticism and a critique of the canon defined both these polemical texts – indeed, Sexual Politics is perhaps the first feminist literary critical text – and these themes also occupied the women who set up the glut of feminist publishing houses that were established in the UK in the 1970s and 1980s. The feminist publishing phenomenon was predicated on the second wave idea that literature was a tool to gaining empowerment: hence the refrain ‘this book changed my life’. The feminist publishing houses took up the call to expose the biases of the English literary tradition by publishing early critical work engaged with this task. They also instituted reprint series that revealed the limitations and exclusions of the canon, and expanded its boundaries to include many more women writers. Both Millett and Greer also problematised the normalising of binaried sexual behaviour – men as active, women as passive – in literature, and set out to counter this. Millett, Greer, and the feminist publishers have left a vital legacy. They shared the project of interrogating ‘great’ male literature, both in terms of its content and how the canon sets the boundaries of ‘greatness’. This article considers the intersections between them as the second wave got underway in the UK in the 1970s, examining what they have achieved in terms of feminist history and their ongoing influence on current formulations of feminist politicking.
Is It Worth It? How Your Brain Decides to Make an Effort

Everything you do requires you to exert effort. For instance, basic things like walking or cycling require physical effort and have to do with using your body. Another type of effort is cognitive effort, which has to do with thinking and using your brain. For instance, think about trying to master a Rubik’s cube. Would you want to put in your effort here? The pleasure of finding a solution might outweigh the effort of thinking hard. Or you may decide that finding a solution is not worth your effort. Why and when would you decide to think hard? In this article, we will explain how you decide to exert cognitive effort and what is happening in your brain while you make this decision.
Case study on password complexity enhancement for smart devices

Smart devices have already become a dally necessity of our life since they play a pivot role to record massive amount of Information of our personal life. Current Internet of TWngs era has been seeing more and more people relying on their devices. However, most people are losing patience to set complex passwords to ensure the security for their devices. To avoid forgetting the passwords, people are more willing to choose simple alphanumeric character combinations that are easy for them to remember and convenient to enter. Therefore, their passwords are of high probability to be cracked or exposed. In tWs paper, we study the potential security problems caused by simple and weak passwords, discuss the drawbacks of some conventional works, and propose three schemes to Increase the complexity of simple passwords. Note that our proposals are based on the prediction that the textual passwords are not difficult for users to remember or enter and the proposed schemes can effldently prevent passwords from being cracked or exposed.
A Novel Bicistronic High-Capacity Gutless Adenovirus Vector That Drives Constitutive Expression of Herpes Simplex Virus Type 1 Thymidine Kinase and Tet-Inducible Expression of Flt3L for Glioma Therapeutics

ABSTRACT Glioblastoma multiforme (GBM) is a deadly primary brain tumor. Conditional cytotoxic/immune-stimulatory gene therapy (Ad-TK and Ad-Flt3L) elicits tumor regression and immunological memory in rodent GBM models. Since the majority of patients enrolled in clinical trials would exhibit adenovirus immunity, which could curtail transgene expression and therapeutic efficacy, we used high-capacity adenovirus vectors (HC-Ads) as a gene delivery platform. Herein, we describe for the first time a novel bicistronic HC-Ad driving constitutive expression of herpes simplex virus type 1 thymidine kinase (HSV1-TK) and inducible Tet-mediated expression of Flt3L within a single-vector platform. We achieved anti-GBM therapeutic efficacy with no overt toxicities using this bicistronic HC-Ad even in the presence of systemic Ad immunity. The bicistronic HC-Ad-TK/TetOn-Flt3L was delivered into intracranial gliomas in rats. Survival, vector biodistribution, neuropathology, systemic toxicity, and neurobehavioral deficits were assessed for up to 1 year posttreatment. Therapeutic efficacy was also assessed in animals preimmunized against Ads. We demonstrate therapeutic efficacy, with vector genomes being restricted to the brain injection site and an absence of overt toxicities. Importantly, antiadenoviral immunity did not inhibit therapeutic efficacy. These data represent the first report of a bicistronic vector platform driving the expression of two therapeutic transgenes, i.e., constitutive HSV1-TK and inducible Flt3L genes. Further, our data demonstrate no promoter interference and optimum gene delivery and expression from within this single-vector platform. Analysis of the efficacy, safety, and toxicity of this bicistronic HC-Ad vector in an animal model of GBM strongly supports further preclinical testing and downstream process development of HC-Ad-TK/TetOn-Flt3L for a future phase I clinical trial for GBM.
Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug–drug interactions

Clinical outcome following 3,4-methylenedioxymethamphetamine (MDMA) intake ranges from mild entactogenic effects to a life-threatening intoxication. Despite ongoing research, the clinically most relevant mechanisms causing acute MDMA-induced adverse effects remain largely unclear. This complicates the triage and treatment of MDMA users needing medical care. The user’s genetic profile and interactions resulting from polydrug use are key factors that modulate the individual response to MDMA and influence MDMA pharmacokinetics and dynamics, and thus clinical outcome. Polymorphisms in CYP2D6, resulting in poor metabolism status, as well as co-exposure of MDMA with specific substances (e.g. selective serotonin reuptake inhibitors (SSRIs)) can increase MDMA plasma levels, but can also decrease the formation of toxic metabolites and subsequent cellular damage. While pre-exposure to e.g. SSRIs can increase MDMA plasma levels, clinical effects (e.g. blood pressure, heart rate, body temperature) can be reduced, possibly due to a pharmacodynamic interaction at the serotonin reuptake transporter (SERT). Pretreatment with inhibitors of the dopamine or norepinephrine reuptake transporter (DAT or NET), 5-HT2A or α-β adrenergic receptor antagonists or antipsychotics prior to MDMA exposure can also decrease one or more MDMA-induced physiological and/or subjective effects. Carvedilol, ketanserin and haloperidol can reduce multiple MDMA-induced clinical and neurotoxic effects. Thus besides supportive care, i.e. sedation using benzodiazepines, intravenous hydration, aggressive cooling and correction of electrolytes, it is worthwhile to investigate the usefulness of carvedilol, ketanserin and haloperidol in the treatment of MDMA-intoxicated patients.
The cognitive surplus is made of fossil fuels

People in the industrial world have a great deal of free time. Clay Shirky has described this free time, considered as a whole, as a vast “cognitive surplus,” and presents many efforts currently under way to use the cognitive surplus for prosocial ends. However, the cognitive surplus came to exist largely as a result of labor–saving devices that run on fossil fuels. Many problems relating to fossil fuels constrain how people can responsibly use the cognitive surplus to address environmental sustainability and other current concerns. We suggest that an excellent use of the present cognitive surplus is to help society prepare for an energy–scarce future — that is, a future that may not be able to support the existence of a cognitive surplus at the current level.
One Step Forward, Two Steps Back: Worker Representation and Health and Safety in the United Kingdom

There is now quite strong evidence for a set of preconditions that help determine the effectiveness of worker representation and consultation in improving health and safety outcomes. One of these preconditions is a regulatory framework that defines workers' rights to representation and employers' obligations to respond. Using the United Kingdom as its focus, this article explores developments at the national policy level. It shows how long-awaited legislative reforms to improve provisions for worker representation in health and safety have so far failed to materialize and, instead, government strategy has concentrated on promoting voluntary approaches. The author reviews the evidence of what makes worker representation in health and safety effective and suggests that, far from abandoning approaches to legislative reform, the U.K. agencies should be seeking to make improvements to the British provisions if they are to provide the necessary stimulus and support for worker representation in health and safety at work. Such improvements need to address long-standing weaknesses in existing provisions and their relevance to the changing world of work. The arguments presented here apply to the essential role of regulatory support for worker participation in all advanced market economies if it is to improve health and safety outcomes.
Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor

Fibroblast growth factor receptor 4 (FGFR4) contains a Gly388Arg functional polymorphism (rs351855) that has shown contrasting results in association studies. In this study, we assessed the association between the FGFR4 Gly388Arg polymorphism and cancer prognosis. Meta-analysis and pooled analysis of 6817 and 2537 cancer cases, respectively, were carried out by nodal status and overall survival. The study included the following types of cancer: brain, breast, colorectal, head and neck, larynx, lung, melanoma, prostate, sarcomas. A statistically significant association between the Arg388Arg genotype and nodal involvement was found in the meta-analysis (odds ratio=1.33, 95% confidence interval 1.01–1.74). In the pooled analysis, the Arg388 allele carriers showed an increased hazard of poor overall survival compared with homozygous carriers of the common Gly388 allele, even after adjusting for nodal status (hazard ratio=1.21, 95% confidence interval 1.05–1.40). These results provide evidence of a role for the FGFR4 Gly388Arg polymorphism in modulating patients' outcome in different types of cancer, thus offering to clinicians a new marker to predict predisposition to poor survival in cancer patients.