Miracle-dz/UniFAR-FTUs huggingface dataset:
Abstract S2-06: Survival advantage of anastrozol compared to tamoxifen for lobular breast cancer in the ABCSG-8 study

Introduction: Invasive lobular cancer (ILC) is the second most common histological type of breast cancer, appearing to have a biology distinct from ductal cancer (IDC). In the first 5 years, the prognosis of ILC seems to be more favourable compared to IDC. The aim of this study was to investigate the differences in benefit from adjuvant Tamoxifen (Tam) and Anastrozol (Ana) for these histologic subtypes. Patients and Methods: The ABCSG-8 (Austrian Breast and Colorectal Cancer Study Group 8) study was a randomized phase III clinical trial (n=3.714) in hormone receptor-positive cancer addressing a sequence strategy with 3 years of Ana after 2 years of Tam in comparison with 5 years of Tam in a low- to intermediate-risk group (Grade 1/2) of postmenopausal patients not receiving adjuvant chemotherapy. Univariate and multivariate comparisons for overall (OS) and disease-free survival (DFS) between endocrine treatments were conducted per subgroup with respect to histology (ductal or lobular). Multivariate Cox analysis included endocrine treatment, histology and their interaction ± additional covariates (age, T-stage, N-stage, grade, ER, PR). For the time-to-event analyses, starting point for all patients was two years after randomization, i.e. when treatment changed from Tamoxifen to Anastrozole on the experimental arm. To avoid crossover effects for post-study treatment, the total time for this analysis is 3 years. Results: The 3-year OS hazard ratio (HR) for Anastrozol versus Tamoxifen in ILC (n=694) was 0.24 (0.08-0.70) vs. IDC (n=2.739) HR 1.08 (0.75-1.58). In multivariate analysis, HR for ILC was 0.23 (0.08-0.68) vs. 1.02 (0.70-1.49) for IDC. The test for interaction of treatment and histology was significant (p=0.01). In ILC, no other clinico-pathologic factor was significantly associated with survival differences compared to IDC, where age, T- and N-stage maintained significance. In the models for DFS, our preliminary analysis after 3-year follow-up did not show significant variations in treatment effect according to histology. Discussion: The magnitude of survival benefit from adjuvant Anastrozol vs. Tamoxifen varies by histology in this large phase III randomized trial. A significant reduction in risk of death occurs only in patients with lobular cancer compared to ductal cancer after only 3 years of follow-up. An updated analysis with additional follow-up will be available at presentation. Citation Format: Michael Knauer, Christine Gruber, Otto Dietze, Richard Greil, Herbert Stoger, Margaretha Rudas, Zsuzsanna Bago-Horvath, Brigitte Mlineritsch, Werner Kwasny, Christian Singer, Peter Dubsky, Raimund Jakesz, Florian Fitzal, Gunther Steger, Rupert Bartsch, Martin Filipits, Christian Fesl, Michael Gnant. Survival advantage of anastrozol compared to tamoxifen for lobular breast cancer in the ABCSG-8 study [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr S2-06.
Protocol Design and Implementation Using Formal Methods

This paper reports on a number of formal methods that support correct protocol design and implementation. These methods are placed in the framework of a design methodology for distributed systems that was studied and developed within the ESPRIT II Lotosphere project (2304). The paper focuses on design methods for synthesizing protocols by successive application of correctness-preserving LOTOS transformations. This transformational approach is described in some detail and is illustrated with a protocol design example. The paper concludes with some suggestions for relating design methods to milestones in the protocol design and implementation processes.
Role of isometric hand grip test and resting blood pressure measurement in diagnosing cardiovascular autonomic neuropathy in patients with diabetes mellitus.

Background: Diabetes is an iceberg disease with many complications like cardiovascular disease & diabetic neuropathy. Diabetic autonomic neuropathy is least recognized & most frequent complication. Cardiac autonomic neuropathy is associated with fatal outcome like silent myocardial ischemia & intra- operative liability. With this background we have evaluated the cardiac autonomic neuropathy in diabetic patients using resting blood pressure measurement & isometric hand grip test. Aim:Aim of the study is to analyze the role of handgrip test of & resting blood pressure in diagnosing Cardiac Autonomic Neuropathy. Materials And Methods: A Present cross sectional study was carried out in 50 diabetic patients & 50 controls(age and sex matched) at Sir T. Hospital Bhavnagar. Each subject was evaluated for cardiovascular autonomic neuropathy by isometric hand grip test & resting blood pressure.Diabetic patients were divided in 3 groups according to duration of disease(groupI- 10 year) to evaluate the impact of duration of disease on autonomic nervous system.We have used student's T test for comparisons of result between 2 groups. Result:The mean value of resting systolic blood pressure(RSBP) & resting diastolic blood pressure (RDBP)is comparatively higher in diabetic patients compared to controls t 3(4) : 57-60)
An Efficient Algorithm for Node-to-Node Routing in Hypercubes with Faulty Clusters

In this paper, we study the node-to-node fault tolerant routing problem in n-dimensional hypercubes H n based on the cluster fault tolerant model. For a graph G, a faulty cluster is a connected subgraph of G such that all its nodes are faulty. In cluster fault tolerant routing problems, how many faulty clusters and how large those clusters can be tolerated are studied. It was proved that for node-to-node routing, H n can tolerate as many as n - 1 faulty clusters of diameter at most 1 with at most 2n - 3 faulty nodes in total. In this paper, we give an algorithm which, given at most n - 1 faulty clusters of diameter at most 1 with 2n - 3 faulty nodes in total and non-faulty nodes s and t in H n , finds a fault-free path s → t of length at most n + 2 in O(n) optimal time. The upper bound on the length of the path is optimal when the distance between s and t is n - 2.
Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature.

BACKGROUND Hand-foot syndrome (HFS) is a relatively common dermatologic toxic reaction to certain anticancer therapies. Although not life-threatening, this complication can reduce patient quality of life. Dose modification of the inciting agent serves as the most effective management of HFS, although a variety of anecdotal reports suggest that other agents may also be efficacious. We present the first reported case of fatal HFS (to our knowledge) and provide a comprehensive review of this condition. OBSERVATIONS A 61-year-old woman with metastatic breast cancer who was undergoing treatment with capecitabine developed erythema, fissuring, and erosions over both hands and feet, consistent with HFS. Pseudomonal superinfection leading to bacterial sepsis and death rapidly ensued. CONCLUSIONS Although HFS is widely regarded as a non-life-threatening toxic reaction to cancer treatment, our case demonstrates that infectious complications of this condition can prove fatal. Prevention, early recognition, and implementation of various management strategies for HFS and its infectious complications are important in optimizing patient quality of life and minimizing unfavorable outcomes.
How to dissect surgical journals: VII – The concept of outcome

Outcome events should be securely linked to the aim of the study. But the reality is that many articles lack clear definitions of the outcome events (readers tend to take familiar terms on their face value). Worst of all are the studies that provide a diffuse aim followed by a mosaic of measurements. This inevitably ends with a confusing overload of P values. There are two types of clinical studies, ‘explanatory’ and ‘pragmatic’. Explanatory studies look at underlying processes, whilst pragmatic studies provide management recommendations that are relevant to clinical practice. This uneasy compromise can lead to studies that fail to achieve either.
IL‐15‐deficient mice develop enhanced allergic responses to airway allergen exposure

Interleukin‐15 is a pleiotropic cytokine that is critical for the development and survival of multiple haematopoietic lineages. Mice lacking IL‐15 have selective defects in populations of several pro‐allergic immune cells including natural killer (NK) cells, NKT cells, and memory CD8+ T cells. We therefore hypothesized that IL‐15−/− mice will have reduced inflammatory responses during the development of allergic airway disease (AAD).
Functional Disorders of Constipation: Paradoxical Puborectalis Contraction and Increased Perineal Descent

Abstract Paradoxical puborectalis contraction (PPC) and increased perineal descent (IPD) are subclasses of obstructive defecation. Often these conditions coexist, which can make the evaluation, workup, and treatment difficult. After a thorough history and examination, workup begins with utilization of proven diagnostic modalities such as cinedefecography and anal manometry. Advancements in technology have increased the surgeon's diagnostic armamentarium. Biofeedback and pelvic floor therapy have proven efficacy for both conditions as first-line treatment. In circumstances where PPC is refractory to biofeedback therapy, botulinum toxin injection is recommended. Historically, pelvic floor repair has been met with suboptimal results. In IPD, surgical therapy now is directed toward the potentially attendant abnormalities such as rectoanal intussusception and rectal prolapse. When these associated abnormalities are not present, an ostomy should be considered in patients with IPD as well as medically refractory PPC.
Harlequin ichthyosis: a review of clinical and molecular findings in 45 cases.

OBJECTIVE To assess the clinical outcomes of 45 cases of harlequin ichthyosis and review the underlying ABCA12 gene mutations in these patients. DESIGN Multicenter, retrospective, questionnaire-based survey. SETTING Dermatology research institute. PARTICIPANTS Patients with harlequin ichthyosis for whom we had performed ABCA12 mutation analysis. MAIN OUTCOME MEASURES Referring physicians were asked to complete a questionnaire using the patients' notes, detailing the clinical outcome of the affected child. In each case, the causative ABCA12 mutation was identified using standard polymerase chain reaction and sequencing techniques. RESULTS Of the 45 cases, the ages of the survivors ranged from 10 months to 25 years, with an overall survival rate of 56%. Death usually occurred in the first 3 months and was attributed to sepsis and/or respiratory failure in 75% of cases. The early introduction of oral retinoids may improve survival, since 83% of those treated survived, whereas 76% who were not given retinoids died. Recurrent skin infections in infancy affected one-third of patients. Problems maintaining weight affected 44%. Three children developed an inflammatory arthritis, and developmental delay was reported in 32%. Mutation analysis revealed that 52% of survivors had compound heterozygous mutations, whereas all deaths were associated with homozygous mutations. CONCLUSIONS Harlequin ichthyosis should be regarded as a severe chronic disease that is not invariably fatal. With improved neonatal care and probably the early introduction of oral retinoids, the number of survivors is increasing. Compound heterozygotes appear to have a survival advantage.
Identification of unique proteomic signatures in allergic and non‐allergic skin disease

Atopic dermatitis (AD), psoriasis (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and systemic inflammation, with unique epidermal signatures and common inflammatory pathways identified by transcriptomic profiling. This study profiled proteomic signatures in serum from subjects with AD, PS, and CD compared with healthy controls (HC).
Mycotoxin Contamination of Foods in Africa: Antinutritional Factors

Mycotoxins are regulated in foods and feeds because of carcinogenic (aflatoxin), immunotoxic (deoxynivalenol), or environmental estrogenic (zearalenone) properties. In addition to having tumorigenic properties, many mycotoxins are antinutritional factors that cause unthrifty growth and immune suppression in young animals. In the developed world, human exposure, and particularly exposure of children, to dietary mycotoxins is virtually nonexistent because of regulatory standards. In developing countries, monitoring and enforcement of standards is rare, and mycotoxin-susceptible foods are often the primary staples in rather undiversified diets. In sub-Saharan Africa, people are exposed to unsafe levels of various mycotoxins, often in mixtures, and the consequences in terms of public health burden have been ignored. This paper presents information on the health effects that have been attributed to mycotoxin exposure from the medical research literature and data on existing mycotoxin levels in maize in West and Central Africa. The International Institute of Tropical Agriculture (IITA), in its Maize Integrated Pest Management Project, has recognized mycotoxins as one of the most important constraints to the goal of improving human health and well-being through agriculture. An overview of various research and development activities at the Institute is given.
Phenotypic and Genotypic Characteristics of Listeria monocytogenes Isolated From Dairy and Meat Products

Background: Listeria monocytogenes is a foodborne pathogen and a serious threat to the public health in the world. Consumption of traditional foods such as dairy and meat products can be a major reason for relative abundance and isolation of these bacteria. Objectives: The purpose of this study was to determine the phenotypic and genotypic characteristics of L. monocytogenes strains isolated from dairy and meat products. Materials and Methods: A total of 317 dairy products and meat-processed samples were collected. Antibiotic susceptibility test was performed on each sample by the disk diffusion method (Kirby Bauer). Five reference loci were used for typing of L. monocytogenes strains by MLVA (Multiple Locus VNTR Analysis) Technique. Results: A total of 24 L. monocytogenes isolates were collected from the dairy and meat products. Resistance of isolated L. monocytogenes strains to penicillin G were 54.54% (from dairy products) and 46.15% (from processed meat). Genetic relatedness of isolates were assessed by MLVA. Out of 13 different types, type 2 with 6 strains and type 3 with 4 strains, were the most common types. Conclusions: MLVA analysis showed that samples obtained from different sources could have similar genetic profile. As a result, administration of penicillin in patients with listeriosis (especially pregnant women) and antibiotic susceptibility test are recommended. The fast and accurate methods such as MLVA for tracking of pollution sources of L. monocytogenes are recommended during outbreaks.
New and emerging drug treatments for severe asthma

Asthma is a common chronic inflammatory condition of the airways affecting over 300 million people world‐wide. In 5%‐10% of cases, it is severe, with disproportionate healthcare resource utilization including costs associated with frequent exacerbations and the long‐term health effects of systemic steroids. Characterization of inflammatory pathways in severe asthma has led to the development of targeted biological and small molecule therapies which aim to achieve disease control while minimizing corticosteroid‐associated morbidity. Herein, we review currently licensed agents and those in development, and speculate how drug therapy for severe asthma might evolve and impact on clinical outcomes in the near future.
Osseocartilaginous rib graft rhinoplasty: a stable, predictable technique for major dorsal reconstruction.

OBJECTIVE To assess the long-term stability of osseocartilaginous dorsal onlay rib grafts used for augmentation rhinoplasty. METHODS Patients who had rib grafts used for augmentation rhinoplasty from 2000 through 2009 were assessed for graft viability, graft mobility, graft warping, maintenance of dorsal projection, functional airway status, need for revision surgery, and donor site morbidity. A retrospective cohort study using telephone follow-up was conducted. RESULTS A total of 58 rib graft rhinoplasties were performed in the 10-year review period, 39 of which used dorsal onlay grafts. The mean duration of clinical follow-up was 24 months, and the median duration of clinical follow-up was 16 months. Thirty-three of 33 osseocartilaginous onlay grafts (100%) and 5 of 6 cartilaginous onlay grafts (83%) were viable, rigid, and had maintained dorsal projection at last follow-up. None of the grafts warped. Twenty-nine of 33 patients receiving osseocartilaginous onlay grafts (88%) and 5 of 6 patients receiving cartilaginous onlay grafts (83%) had persisting relief of their nasal obstruction. Twelve of the 39 patients (30%) had revision surgery, mostly performed for minor cosmetic revision. CONCLUSIONS Osseocartilaginous onlay rib grafts provide an ideal scaffold for dorsal nasal augmentation and restoration of nasal airway in patients with collapse of the nasal framework due to a saddle deformity, history of trauma, or history of multiple septorhinoplasties. The graft has excellent viability, lacks potential for long-term warping, achieves bony fusion to the nasal bones, and allows surgical molding of the cartilaginous tip.
Isoflurane Versus Propofol (AIVOC) pour l’Hypotensionarterielle controlee en chirurgie ORL (Étude prospective à propos de 73 cas)

M. Professeur M. Professeur . Professeur M. HARANDOU MUSTAPHA Professeur KANJAA NABIL Anesthésie réanimation KHATOUF MOHAMMED Anesthésie réanimation EL ALAMI EL AMINE MOHAMED NOUR-DINE . d’ . agrégé d’ M . d’Oto-Rhino-Laryngologie . agrégé d’Anesthésie réanimation JUGE PRESIDENT
Health literacy training: A model for effective implementation and sustainability.

OBJECTIVE Training the mental health workforce to provide health promotion and support to people using their services to manage comorbid conditions is essential if full integration of physical and mental health is to become a reality. We document how a training model was explicitly designed to extend curricula beyond the classroom in order to increase the frequency and quality of physical health interventions. We also show how implementation was supported by a strong project structure and a facilitative administration. METHOD This article was informed by the workforce development literature, process observations, and key informant interviews. RESULTS Passive dissemination cannot change practice. Buy-in and commitment from agency leaders facilitates collaboration between consultant-trainers and trainees. Organizations with strong implementation structures help ensure training uptake. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE When contracting with trainers, ensure that they understand the need for and are willing to commit to sustainability. Additionally, organizations will benefit by using lessons from implementation science when approaching workforce.
Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.

CONTEXT Variations in the brain-derived neurotrophic factor gene (BDNF) have been associated with psychiatric disorders. Deep sequencing of the BDNF gene may identify new variations and bring further insight into psychiatric genetics. OBJECTIVE To better characterize sequence variability in the BDNF gene by resequencing a genomic DNA region of 22 kilobases that contained all BDNF exons and their flanking regions. DESIGN Case-control study. SETTING University of California, Los Angeles, and University of Miami. PARTICIPANTS Two hundred sixty-four controls and 272 Mexican Americans with major depressive disorder (MDD) from Los Angeles who were assessed by the same bilingual clinical research team. MAIN OUTCOME MEASURES Identification of novel genetic polymorphisms in the BDNF gene and assessment of their frequencies and associations with MDD or antidepressant response. RESULTS We identified 83 novel single-nucleotide polymorphisms (SNPs): 30 in untranslated regions, 4 in coding sequences, 37 in introns, and 12 in upstream regions; 3 of 4 rare novel coding SNPs were nonsynonymous. Association analyses of patients with MDD and controls showed that 6 SNPs were associated with MDD (rs12273539, rs11030103, rs6265, rs28722151, rs41282918, and rs11030101) and 2 haplotypes in different blocks (one including Val66, another near exon VIIIh) were significantly associated with MDD. One recently reported 5' untranslated region SNP, rs61888800, was associated with antidepressant response after adjusting for age, sex, medication, and baseline score on the 21-item Hamilton Depression Rating Scale. CONCLUSIONS Our data support the concept that extensive resequencing of key candidate genes can lead to the discovery of substantial numbers of new variants. Further studies using larger independent samples are needed to confirm the association of the rs61888800 SNP with antidepressant response. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00265291.