Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic markers and therapeutic targets for metastatic renal cell carcinoma

Targeting cancer metastasis has gained considerable importance in the recent years when aiming to increase patients’ overall survival. In Renal Cell Carcinoma (RCC), the discovery of metastatic biomarkers and targets is still required, as most patients present metastatic disease at the time of diagnosis. Therefore, the aim of this thesis is the discovery of new biomarkers and targets of metastatic RCC using two variants of a patient-derived orthoxenograft (PDOX) animal model of clear cell RCC (ccRCC). Indeed, PDOX models have recently gained significant relevance for studying the progression of cancer and metastasis, due to their better mimicking of the histology, the metastatic capacity and treatment responses of human cancers. To this purpose, previous results had sequenced the two variants of this PDOX model, both at DNA and at RNA level, and had performed a FISH analysis. Firstly, Carboxypeptidase E (CPE), which was one of the highest expressed genes in the metastatic variant, has demonstrated to play a role in invasion when it is secreted to the medium, even though its overexpression alone is not sufficient to generate metastasis in vivo. In addition, it has showed a clear association to ccRCC and an inverse correlation with the overall survival of these patients. Secondly, we have studied two molecules of the coagulation pathway due to its relevance as one of the most upregulated pathways at RNA level. On the one hand, Factor XIII (FXIII or F13) has shown to be related to CPE in vivo, despite the overexpression of both molecules is not sufficient to develop all the metastatic cascade. However, it also affects the overall survival of ccRCC patients, highlighting these two molecules as possible biomarkers for this type of cancer. On the other hand, Coagulation Factor II Thrombin Receptor (F2R or PAR1) has demonstrated to play a role in metastasis, since its inhibition reduces both the early and late phases of this process. With the use of F2R inhibitors and the clinical association of the coagulation pathway to worse prognosis, this thesis opens new opportunities for the treatment of metastasis and cancer malignization. In summary, we have discovered new metastatic biomarkers and targets which, together with further validations, especially in the clinical setting, are proposed to be useful for RCC patients in the future.
An Inter-Domain Attack Mitigating Solution

Online services on the Internet are increasing day by day, and in parallel, the number of cyber-attacks is rapidly increasing. These attacks are not always about data theft, but they can cause severe damage by denial of service attacks. Intrusion Prevention System products that many organizations use at the border of their enterprise networks are not strong enough to protect against DoS attacks. The typical way to mitigate such attacks is to get support from a service provider. However, a service provider only provides solutions for the traffic originating from itself. If the source of attack is in another ISP domain, it is possible to inform that ISP via phone or e-mail. As a result, the source of the attack is blocked by the manual intervention of the service provider whose domain hosts it. Border Gateway Protocol BGP based solutions are also available for automating a blocking system, but not all enterprise networks support BGP. In this research, we have developed a centralized automation solution for software defined network SDN environments that is capable of preventing cyber-attacks at the source of attack. This solution does not require any BGP support. Non-SDN environments can also use this attack mitigation and notification system. In the long run, we may use this system to create a national protection shield in order to mitigate Cybersecurity attacks.
The Impact of Cooperative Learning Strategy on the Accomplishment of Selected Athletics Skill and Some Physical Abilities among Pupils

The study aimed to identify the impact of cooperative learning strategy on the accomplishment of athletics skill (long jump)and some physical abilities. The sample of the study consisted of (20) students from the Syrian refugees affiliated to Jerash district in North Jordan. An instructional program was formed by using cooperative strategy to teach selected athletics activities along with some physical abilities. The program was applied for six weeks in order to identify its impact on improving performance of the pupils in the dependent measures.Quasi-experimental approach was chosen as a research design to test the hypothesis of the study.Statistical methods represented by arithmetic means, standard deviations, variation coefficient, correlation coefficients and t-Test were used for data analysis. The results of the study showed that the instructional program based on cooperative learning strategy has a positive effect on learning athletics skill and showed significant enhancements in the level of physical ability tests in post-test measurements. The researchers recommend applying the instructional program based in cooperative learning to teach different athletics curricula.
Forecasting Accuracy of Earliest Assessment Versus Transitional Change in Early Education Classroom Problem Behavior Among Children at Risk

ABSTRACT This study compared the relative contribution of earliest assessment of preschool children’s context-specific problem behaviors with subsequent observations of those behaviors for the prediction of later academic and sociobehavioral performance in first grade. Using a nationally representative sample of low-income children from the Head Start Impact Study (N = 3,827), children’s problem behaviors in 22 classroom situational contexts were assessed annually through 2 years of prekindergarten, kindergarten, and first grade. Results from a two-stage analytical approach support the use of earliest assessment as a suitable strategy for the identification and intervention of children’s classroom problem behaviors, where subsequent observations did not increase predictive accuracy over earliest assessment alone. Implications are discussed for assessment theory and practice.
Effects of ambient temperatures and exercise modality on neuromuscularexcitability in people with multiple sclerosis

The objective of this thesis was to examine how ambient temperatures ((Cool (16°C) vs. Room (21°C)) and exercise modality ((upright (Treadmill) vs. recumbent stepper (NuStep)) effects the neuromuscular excitability in people with Multiple Sclerosis (PwMS). Fourteen heat sensitive MS patients (10 Females), 49.28 ± 13.56 years of age with relapsing remitting MS and baseline expanded disability status scores ranging from 3.4 ± 2.37 participated in the study. Transcranial magnetic stimulation (TMS) elicited motor evoked potentials (MEPs) were recorded and assessed prior to and following aerobic exercise interventions at 65% of VO₂max. Tibial nerve stimulation elicited maximal muscle compound action potential (Mmax). Measurements were taken from the tibialis anterior, lateral gastrocnemius and soleus muscle of the weakest limb, both at rest and during a torque equivalent to 10% of maximal voluntary contraction (MVC). Participants attended four randomized experimental sessions including temperature ((Cool (16°C) and Room (21°C)) and exercise modality ((Treadmill (T) and NuStep (N)). Therefore, the experimental sessions were T in cool (TC), T in room (TR), N in cool (NC) and N in room (NR). MEP amplitudes were made relative toMmax amplitudes for analysis. The results showed that exercising on a NuStep in a cool ambient temperature resulted in greater MVC and peak twitch (PT) torque, reduced half relaxation time (HRT) and no change in Mmax indicating that exercising in a cool environment enhances voluntary contraction and electrically evoked contractile properties of the muscle in PwMS. Furthermore, MEPs were elicited more readily following exercise using the NuStep as compared to the treadmill. Regardless of ambient temperature and/or exercise modality; the number of MEPs elicited was strongly correlated with the neurological disability measured through the EDSS (i.e., the occurrence of MEPs was reduced significantly with increasing motor impairments). Strong correlations were also observed with neurological disability for: 1) MVC and 2) EMG of the LG and SOL. Furthermore, post exercise aural temperatures recorded did not change after exercising in cool (16°C) ambient temperature conditions, but were increased in room (21°C) temperature conditions. Overall, the experiment demonstrated that neuromuscular excitability of the lower limb is affected by the exercise modality and ambient temperature conditions, and PwMS should exercise in a cooler temperature conditions on non-weight bearing exercise modality such as NuStep.
A contribution to the genera Plectonotum Gorham and Hyponotum Wittmer, with the description of sixteen new species from Peru (Coleoptera, Cantharidae)

Sixteen species of Peruvian Dysmorphocerinae (Cantharidae) are described as new (regions in parenthesis): Hyponotum macrocephalum sp. nov. (Huanuco); H. succhabamba sp. nov. (Cajamarca); Plectonotum altomayo sp. nov. (Amazonas); P. amazonas sp. nov. (Amazonas); P. bicoloricolle sp. nov. (Huanuco); P. carpish sp. nov. (Huanuco); P. celendin sp. nov. (Cajamarca); P. costae sp. nov. (Cajamarca); P. huariaca sp. nov. (Pasco and Huanuco); P. huascaran sp. nov. (Ancash); P. huertoae sp. nov. (Cajamarca); P. leymebamba sp. nov. (Amazonas); P. luteipes sp. nov. (Amazonas); P. oxapampa sp. nov. (Pasco); P. rubrithorax sp. nov. (Huanuco); P. shipasbamba sp. nov. (Amazonas). A lectotype is designated for Plectonotum longissimum (Pic, 1927) for which a redescription is provided. Plectonotum ruficolle Wittmer, 1988, homonym of Plectonotum ruficolle Pic, 1926, is renamed as Plectonotum neoruficolle nom. nov. New keys are proposed in English and Spanish for the identification of the Peruvian species of the genus Plectonotum and the South American species of the genus Hyponotum Wittmer, together with macrophotographs of habitus, details of pronotum, male genitalia and a cartographic representation of their distribution.
La experiencia Nespresso, el Marketing Sensorial aplicado al sector del café

Las últimas tendencias en marketing encaminan las marcas al mundo de las experiencias como punto de encuentro, donde el usuario conecta directamente con la firma y se crea un vínculo emocional y personalizado entre ambos. Así nace el marketing experiencial. Con este planteamiento, se desarrolla el nuevo concepto de tiendas temáticas que venden entretenimiento, una experiencia en toda regla: las flagship stores. La presente investigación estudia qué factores del marketing sensorial intervienen en la comercialización Nespresso en su punto de venta. Con unos positivos resultados, se entiende que el marketing de sensaciones es una disciplina clave para crear conexiones emocionales entre la marca y su público.
Isolation and identification of lactic acid bacteria in fresh plants and in silage from Opuntia and their effects on the fermentation and aerobic stability of silage

Abstract The current study aimed to select the strains of lactic acid bacteria (LAB) isolated from forage cactus plants and silage and assess their effects on silage fermentation and aerobic stability. Forty wild isolates from plant and cactus silage, classified as LAB, were evaluated for metabolite production and identified by 16S ribosomal DNA sequencing. These wild isolates were identified as Lactobacillus plantarum, Weissella cibaria, Weissella confusa and Weissella paramesenteroides and the LAB populations differed among the silage. The use of microbial inoculants did not influence gas or effluent losses in forage cactus silage. The silage inoculated with the microbial strain GP15 showed the highest number of LAB populations. The amounts of water-soluble carbohydrates (WSC) and ammonia nitrogen differed among the silage. The silage inoculated with the GP1 strain presented the highest WSC. Populations of enterobacteria and yeasts and moulds were below the minimum detection limit (<2.0 log cfu/g silage) in all the silage studied. The predominant action of inoculants was to maximize dry matter recovery of the silage, which could be the criterion adopted to select the strains of LAB for use as inoculants in Opuntia silage.
The importance of climatic variability and human influence in driving aspects of temporarily open‐closed estuaries

Freshwater availability is a major topic in scientific literature and the public domain. Estuaries are complex and dynamic ecosystems that depend on freshwater inflow from their catchments and exchange with the marine environment. Catchment forcings are subject to shifts in frequency and intensity due to regional hydrological variability over time. Human manipulation of freshwater regimes may further alter this beyond natural variability through flow abstraction and additional inputs in the form of wastewater. To elucidate the effect of climate variability and human activities, we conducted a time series investigation on hydrological drivers into a small South African estuary (uMdloti), representative of temporarily open‐closed estuaries. Subsequently, we investigated the ability of the hydrological variables to drive physical parameters and microalgae in the estuary. Freshwater abstraction caused a disconnect between rainfall and river flow, and increased lag times during dry spells, peaking at 115 days. Annual seasonal peaks in rainfall were not represented in river flow due to the dam. Wastewater discharges equate to 4% of the mean annual runoff from the catchment, which has reduced from a natural runoff of 85.8 to 71.9 Mm−3year−1. Due to this and damming of catchment flows, wastewater discharging into the estuary was the most important driver of water quality in the system, resulting in increased nutrient and decreased dissolved oxygen concentrations, whereas river flow was an important driver at high flow volumes. An understanding of interaction effects between climatic variability and catchment flow manipulation is vitally important to estuarine management and their ecological viability.
Estimador borroso de una planta solar cilindro-parabólica

The estimation of the unobservable states of a process is important when using control techniques that assume, a priori, these values are known. The controllers based on the state space are very efficient and even more when the dynamics of the process are strongly non-linear. One of the processes with very non-linear dynamics, and in which not all the states are observable, is the case of parabolic trough solar plants. In this work an observer based on Fuzzy Logic is presented to estimate the temperature profiles of the loops that form the solar field
Witnessing entrepreneurial perceptions and proclivity in university students

PurposeThis paper analyses the transition of university students from initial perceptions of enterprise to potentially heightened levels of proclivity towards creative behaviours and future entrepreneurial activity.Design/methodology/approachAdopting a positivist approach, an intention-based scorecard survey targeted to two cohorts totalling 75 undergraduate students leading to 150 responses at a Scottish university. These were circulated at start and end sessions of four relevant courses, to establish a measure for self-evaluation with respect to perception and proclivity.FindingsThe data gathered from the Entrepreneurial Scorecard emphasised differences in perception and proclivity between the two cohorts, namely creativity, risk-taking, leadership and business aspiration. This re-emphasised the three identified themes: awareness through trait identification; autonomy through developing enterprising skills; and achievement through practicing entrepreneurial activities. This formed the basis for our novel model in supporting the entrepreneurial development of students: The Perception to Proclivity Process Model.Research limitations/implicationsThis study focusses on a single case and further research within other institutions and domains is encouraged to contextually test the transferability of the two key outputs: the Entrepreneurial Scorecard and the Perception to Proclivity Process Model.Practical implicationsThe practical output of this research is a novel tool for evaluating entrepreneurial perceptions and proclivity through the scorecard. This study adds to the existing research base around entrepreneurial intention and action whilst providing a new model for a guiding framework for the entrepreneurial student and educator journey.Originality/valueThis paper's approach outlines many themes and inherent questions of concern to enterprise educators and university management towards the creation, maintenance, or development of an enterprise course or programme. This research introduces the concepts of entrepreneurial perception and entrepreneurial proclivity, explaining the important role they play in developing students. Additionally, the scorecard has potential for application in a longitudinal context as a means of establishing potential shifts in entrepreneurial perception and proclivity. However, the application is not limited to the scope of higher education, with clear potential to apply this tool and approach within other domains.
Pre- and Postharvest Factors Control the Disease Incidence of Superficial Scald in the New Fire Blight Tolerant Apple Variety “Ladina”

Superficial scald is a physiological disorder that develops during cold storage affecting apples and causes substantial market losses. Malus × domestica cv. Ladina, a new scab resistant and fire blight tolerant variety, commercialized in 2012, shows a physiological disorder similar to superficial scald after storage. Here, we used different pre- and postharvest approaches to characterize the occurrence of these superficial scald symptoms in Malus × domestica cv. Ladina. Over a period of seven years, fruits from multiple orchards were stored for five to seven months and the occurrence of superficial scald was assessed in fruits after cold storage and controlled atmosphere (CA) storage. Apples picked at different stages of ripeness within the same year differed in superficial scald development. Additionally, superficial scald differed significantly between years and locations, strongly suggesting that maturity at harvest, weather during the growing season, and orchard management play important roles in scald occurrence. Treatment with 1-methylcyclopropene (1-MCP) after harvest, and storage in a dynamically controlled atmosphere (DCA) significantly reduced the occurrence of superficial scald, whereas storage under ultralow oxygen concentrations (ULO) showed mild but not significant effects. Low calcium concentrations in the fruit flesh and peel were associated with stronger superficial scald occurrence.
Metin Madenciliği ve Duygu Analizi Yöntemleri ile Sosyal Medya Verilerinden Rekabetçi Avantaj Elde Etme: Turizm Sektöründe Bir Araştırma (Gaining Competitive Advantage from Social Media Data with Text Mining and Sentiment Analysis Methods: A Research in Tourism Sector)

* Ahmet BÜYÜKEKE a , Alptekin SÖKMEN b , Cevriye GENCER c a Adana Alparslan Türkeş Science and Technology University, Faculty of Business, Department of Management Information Systems, Adana/Turkey b Hacı Bayram Veli University, Faculty of Economics and Administrative Sciences, Department of Business, Ankara/Turkey c Gazi University, Faculty of Engineering, Department of Industrial Engineering, Ankara/Turkey
Factors Influencing Customers Buying Decision towards Shopping Online and Offline with Reference to Coimbatore City

In recent years the technology plays a vital role towards making the consumers purchase the products. The online portals and offline shopping varieties play a key role in deciding the buying behaviour of a customer. The main objective of the study is to analyse the factor influencing customers buying decision towards shopping online and offline. For this purpose a sample of 150 was collected from the respondents were percentage analysis, descriptive statistics, multiple regression and one way anova were used as tools to analyse the data. The conclusion is that the consumers are often purchasing from online and offline sources because of the revolution in the technology and most of them are purchasing to their need towards a particular product. More effort can be initiated towards influencing the buying behaviour of customers by promoting a product both in online as well as offline so that the companies can satisfy the consumers based on convenience, Personalisation and making the consumers purchase through reviews and feedback.
Teacher emotion regulation strategies in response to classroom misbehavior

ABSTRACT This research examined how teachers regulate their emotions in the context of student misbehaviour and what the affective consequence of this regulation is for teachers. In Study 1 we descriptively examined which strategies teachers use to regulate their emotions in response to student misbehaviour and found that teachers use a variety of strategies to regulate their emotions. In Study 2, using an Experience Sampling Method, we examined how teachers’ trait-level emotion regulation impacts their in-the-moment affective experiences and modulation strategies in the context of classroom misbehaviours. Results indicate that teachers who typically reappraise have the least negative affective experiences in the context of student misbehaviour and are less likely to suppress their in-the-moment negative emotions. This study adds to our understanding of how teachers could regulate their negative emotions when dealing with student misbehaviour in an adaptive way. Findings signify the importance of examining the efficacy of other regulation strategies.
Improved parameterization of the weathering kinetics module in the PROFILE and ForSAFE models

Abstract. Although the PROFILE and ForSAFE model can accurately reproduce the chemical and mineralogical evolution of the soil unsaturated zone, it overestimates weathering rates in deeper soil layers and in groundwater systems. This overestimation has been corrected by improving the kinetic expression describing mineral dissolution by adding or upgrading braking functions . The base cation and aluminium brakes have been strengthened, and an additional silicate brake has been developed, improving the ability to describe mineral- water reactions in deeper soils. These brakes are developed from a molecular-level model of the dissolution mechanisms. Equations, parameters and constants describing mineral dissolution kinetics have now been obtained for 113 minerals from 12 major structural groups, comprising all types of minerals encountered in most soils. The PROFILE and ForSAFE weathering sub-model was extended to cover two-dimensional catchments, both in the vertical and the horizontal direction, including the hydrology. Comparisons between this improved model and field observations are available in Erlandsson Lampa et al. (2019, This special issue). The results showed that the incorporation of a braking effect of silica concentrations was necessary and helps obtain more accurate descriptions of soil evolution rates at greater depths and within the saturated zone.