Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the role of customers’ perceptions of employee effort and justice in service recovery

The purpose of this paper is, first, to identify the relationship, if any, between customers’ perceptions of justice (functional element) and employee effort (symbolic element) and their effects on satisfaction and loyalty in the context of service recovery and, second, to determine the impact of cross-cultural differences on these relationships. Survey data from actual customers were gathered in three countries ( n = 414) and analyzed using structural equation modeling to test the proposed hypotheses. The results demonstrate the role of the constructs of perceived employee effort and perceived justice in influencing post-recovery satisfaction and loyalty across cultures. While perceived justice is valued across cultures, customers from feminine (masculine) cultures require more (less) employee effort to influence post-recovery satisfaction positively. Customers from low (high) uncertainty cultures are more (less) willing to give the provider another chance after a service recovery. The study shows that both functional and symbolic elements of service recovery are important determinants of customer satisfaction and loyalty and that their influence can be significant in a cross-cultural context. International service managers must consider the nature of cultural differences in their markets to develop and implement tailored recovery strategies that can result in satisfied customers. This study is the first to integrate the functional and symbolic elements of service recovery, their impact on customers’ behavioral responses and the influence of cultural variations.
Japanese language proficiency index for Koreans by N400

This study explains about the Japanese language proficiency index for Koreans using N400 mismatch response. We considered that N400 potential responds to presentation of erroneous grammar of Japanese language in accordance with the learning level of the Japanese language. Japanese and Korean have the same word order of subject, nominative particle and verb, and the nominative particle determines whether to use intransitive verb or transitive verb. Therefore, sentences with the same meaning in the Japanese and Korean languages were prepared, converted into those with correct grammar and erroneous grammar, and presented to students from Korea to measure the brain waves. As a result, N400 potential significantly responded when an erroneous grammar was presented. In addition, the Korean language showed a larger response than Japanese.
Pathogenesis of haemophilic synovitis: experimental studies on blood‐induced joint damage

Summary. Hemarthrosis is a common manifestation of haemophilia, and joint arthropathy remains a frequent complication. Even though the exact mechanisms related to blood‐induced joint disease have not yet been fully elucidated, it is likely that iron deposition in the synovium induces an inflammatory response that causes not only immune system activation but also stimulates angiogenesis. This process ultimately results in cartilage and bone destruction. Investigating the processes that occur in the early stages of blood‐induced joint disease in humans has been very limited. Therefore, the use of haemophilic animal models is critical to augment the understanding of this phenomenon. This article discusses three cellular regulators (p53, p21 and TRAIL) induced in synovial tissue that are important for iron metabolism. A cartilage remodelling programme induced by the release of cytokines and growth factors that result in articular damage is also discussed. Full elucidation of the pathogenesis of haemophilic joint disease is required to identify new avenues for prevention and therapy.
MODELING ENERGY REGULATED BY BLOCKCHAIN SYSTEM PRODUCTION

The management of the energy produced by photovoltaic panel stations can be converted into a management where the consumer himself can have a tendency in the final price of the price of the energy he pays. The system of generation and sale of energy by means of photovoltaic systems can be managed through global BLOCKCHAIN type procedures.
Open innovation strategy : a framework for corporate-startup collaboration

Recent years have seen important changes in the way corporates compete and the dynamism of this competition. Companies are facing increasing pressure to innovate and generate value for customers in over-satisfied societies demanding more complex business propositions and faster response. These changes lead to greater horizontal and vertical uncertainty, that corporations have to manage while sustaining investment in core assets to ensure short term performance. Open innovation strategies, levering on the internal and external entrepreneurial drive, have been proposed to increase the resilience of corporates while opening the opportunity for nascent ventures to grow in new markets. The design of these programs is an area of active research. This thesis proposes a specific open innovation program. The design implements an integral strategy combining inside-out and outside-in transitions to lower costs and enhance efficiency. The design is sequential and staged, resulting in a flexible, modular program architecture with multiple, specifically designed components (accelerator, innovation center, incubator and CVC) enabling the management of a wide range of deal flows. Thesis Supervisor: Nicholas Meyer Title: Lecturer, MIT Sloan School of Management Entrepreneur in Residence, Martin Trust Center for MIT Entrepreneurship
Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop*

Cdk9 is the catalytic subunit of a general RNA polymerase II elongation factor known as positive transcription elongation factor b (P-TEFb). The kinase function of P-TEFb requires phosphorylation of Thr-186 in the T-loop of Cdk9 to allow substrates to access the catalytic core of the enzyme. To identify human phosphatases that dephosphorylate the T-loop of Cdk9, we used a Thr-186-phosphospecific antiserum to screen a phosphatase expression library. Overexpression of PPM1A and the related PPM1B greatly reduced Cdk9 T-loop phosphorylation in vivo. PPM1A and Cdk9 appear to associate in vivo as the proteins could be co-immunoprecipitated. The short hairpin RNA depletion of PPM1A resulted in an increase in Cdk9 T-loop phosphorylation. In phosphatase reactions in vitro, purified PPM1A could dephosphorylate Thr-186 both with and without the association of 7SK RNA, a small nuclear RNA that is bound to ∼50% of total cellular P-TEFb. PPM1B only efficiently dephosphorylated Cdk9 Thr-186 in vitro when 7SK RNA was depleted from P-TEFb. Taken together, our data indicate that PPM1A and to some extent PPM1B are important negative regulators of P-TEFb function.
An Ebola Virus-Like Particle-Based Reporter System Enables Evaluation of Antiviral Drugs In Vivo under Non-Biosafety Level 4 Conditions

ABSTRACT Ebola virus (EBOV) is a highly contagious lethal pathogen. As a biosafety level 4 (BSL-4) agent, however, EBOV is restricted to costly BSL-4 laboratories for experimentation, thus significantly impeding the evaluation of EBOV vaccines and drugs. Here, we report an EBOV-like particle (EBOVLP)-based luciferase reporter system that enables the evaluation of anti-EBOV agents in vitro and in vivo outside BSL-4 facilities. Cotransfection of HEK293T cells with four plasmids encoding the proteins VP40, NP, and GP of EBOV and firefly luciferase (Fluc) resulted in the production of Fluc-containing filamentous particles that morphologically resemble authentic EBOV. The reporter EBOVLP was capable of delivering Fluc into various cultured cells in a GP-dependent manner and was recognized by a conformation-dependent anti-EBOV monoclonal antibody (MAb). Significantly, inoculation of mice with the reporter EBOVLP led to the delivery of Fluc protein into target cells and rapid generation of intense bioluminescence signals that could be blocked by the administration of EBOV neutralizing MAbs. This BSL-4-free reporter system should facilitate high-throughput screening for anti-EBOV drugs targeting viral entry and efficacy testing of candidate vaccines. IMPORTANCE Ebola virus (EBOV) researches have been limited to costly biosafety level 4 (BSL-4) facilities due to the lack of animal models independent of BSL-4 laboratories. In this study, we reveal that a firefly luciferase-bearing EBOV-like particle (EBOVLP) with typical filamentous EBOV morphology is capable of delivering the reporter protein into murine target cells both in vitro and in vivo. Moreover, we demonstrate that the reporter delivery can be inhibited both in vitro and in vivo by a known anti-EBOV protective monoclonal antibody, 13C6. Our work provides a BSL-4-free system that can facilitate the in vivo evaluation of anti-EBOV antibodies, drugs, and vaccines. The system may also be useful for mechanistic study of the viral entry process.
[Expression of glucose transporter-1 and its correlation with basic fibroblast growth factor and proliferating cell nuclear antigen in epithelial ovarian neoplasm].

OBJECTIVE To study the expression of glucose transporter-1 (GLUT1) and its correlation with basic fibroblast growth factor (bFGF) and proliferating cell nuclear antigen (PCNA) in epithelial ovarian neoplasm. METHODS Streptavidin-peroxidase complex technique was used to examine the expression of GLUT1, bFGF and PCNA protein in six cases of normal ovarian tissue, 20 cases of benign epithelial tumors, seven cases of borderline tumor and 44 cases of epithelial ovarian carcinoma. RESULTS In normal ovary and benign ovarian tumor, GLUT1 was not detected, but in borderline ovarian tumor and cancer, the positive expression ratio of GLUT1 was 6/7 and 91% (40/44), respectively. The intensity of GLUT1 in ovarian epithelial neoplasm was significantly higher than in borderline tumors. The staining intensity of GLUT1 was significantly correlated with the histological grade of the tumor (r(S) = 0.499, P = 0.001), and was positively correlated with the clinical stage, cancer invasion and lymph node metastasis. GLUT1 staining was intense in cytoplasmic membrane, and was stronger in areas far away from blood vessels and near the necrotic center. GLUT(1) expression level did not show any association with histology type (P = 0.513). bFGF positive rate in tumor was 57% (25/44). The staining intensity of GLUT1 was significantly higher in bFGF positive group than in bFGF negative group (P < 0.01). The mean score of PCNA was significantly higher in cancer tissues with strong GLUT1 staining(+++) than that with moderate(++) and low(+) GLUT1 staining (P < 0.05). And the score of PCNA was also significantly higher in bFGF positive group than in bFGF negative group (P < 0.01). CONCLUSIONS (1) The expression of GLUT1 may be closely related to malignant transformation of ovarian epithelial tumors. It is also correlated with clinical stage, cancer invasion and lymph node metastasis, and may be a useful predictor of poor prognosis. (2) bFGF could enhance the expression of GLUT1. Both of them play important roles in the carcinogenesis and progression of ovarian epithelial carcinoma.
An Interprofessional Diabetes Experience to Improve Pharmacy and Nursing Students’ Competency in Collaborative Practice

Objective. To improve pharmacy and nursing students’ competency in collaborative practice by having them participate in an interprofessional diabetes experience involving social networking. Design. An existing elective course on diabetes management was modified to include interprofessional content based on Interprofessional Education Collaborative (IPEC) competency domains. Web-based collaborative tools (social networking and video chat) were used to allow nursing and pharmacy students located on 2 different campuses to apply diabetes management content as an interprofessional team. Assessment. Mixed-method analyses demonstrated an increase in students’ knowledge of the roles and responsibilities of the other profession and developed an understanding of interprofessional communication strategies and their central role in effective teamwork. Conclusion. Interprofessional content and activities can be effectively integrated into an existing course and offered successfully to students from other professional programs and on remote campuses.
Measurement of branching fractions for B → J / ψ η K decays and search for a narrow resonance in the J / ψ η final state

1Nara Women’s University, Nara 630-8506, Japan 2High Energy Accelerator Research Organization (KEK), Tsukuba 305-0801, Japan 3Department of Physics, University of Tokyo, Tokyo 113-0033, Japan 4Pacific Northwest National Laboratory, Richland, Washington 99352, USA 5Institute for Theoretical and Experimental Physics, Moscow 117218, Russia 6School of Physics, University of Sydney, NSW 2006, Australia 7Panjab University, Chandigarh 160014, India 8Indian Institute of Technology Guwahati, Assam 781039, India 9Wayne State University, Detroit, Michigan 48202, USA 10H. Niewodniczanski Institute of Nuclear Physics, Krakow 31-342, Poland 11University of Maribor, 2000 Maribor, Slovenia
Saquinavir induces stable and functional expression of the multidrug transporter P‐glycoprotein in human CD4 T‐lymphoblastoid CEMrev cells

The multidrug transporter P‐glycoprotein (P‐gp) is expressed in HIV‐1 target cells, in a range of pharmacological barriers and in AIDS‐associated tumours. P‐gp substrates include HIV‐1 protease inhibitors (PIs) and anticancer drugs, which are efficiently effluxed from multidrug‐resistant (MDR) cells.
Reduced Biosynthesis of Digalactosyldiacylglycerol, a Major Chloroplast Membrane Lipid, Leads to Oxylipin Overproduction and Phloem Cap Lignification in Arabidopsis[OPEN]

The short inflorescence stem phenotype of a chloroplast lipid mutant is caused by jasmonic acid overproduction, demonstrating a direct link between the biosynthesis of this lipid and jasmonic acid. DIGALACTOSYLDIACYLGLYCEROL SYNTHASE1 (DGD1) is a chloroplast outer membrane protein responsible for the biosynthesis of the lipid digalactosyldiacylglycerol (DGDG) from monogalactosyldiacylglycerol (MGDG). The Arabidopsis thaliana dgd1 mutants have a greater than 90% reduction in DGDG content, reduced photosynthesis, and altered chloroplast morphology. However, the most pronounced visible phenotype is the extremely short inflorescence stem, but how deficient DGDG biosynthesis causes this phenotype is unclear. We found that, in dgd1 mutants, phloem cap cells were lignified and jasmonic acid (JA)-responsive genes were highly upregulated under normal growth conditions. The coronative insensitive1 dgd1 and allene oxide synthase dgd1 double mutants no longer exhibited the short inflorescence stem and lignification phenotypes but still had the same lipid profile and reduced photosynthesis as dgd1 single mutants. Hormone and lipidomics analyses showed higher levels of JA, JA-isoleucine, 12-oxo-phytodienoic acid, and arabidopsides in dgd1 mutants. Transcript and protein level analyses further suggest that JA biosynthesis in dgd1 is initially activated through the increased expression of genes encoding 13-lipoxygenases (LOXs) and phospholipase A-Iγ3 (At1g51440), a plastid lipase with a high substrate preference for MGDG, and is sustained by further increases in LOX and allene oxide cyclase mRNA and protein levels. Our results demonstrate a link between the biosynthesis of DGDG and JA.
What is Dialectic

Karl Popper famously opposed Marxism in general and its philosophical core – the Marxist dialectic – in particular. As a progressive thinker, Popper saw in dialectic a source of dogmatism damaging to philosophy and political theory. Popper had summarized his views on dialectic in an article that was first delivered in 1937 and subsequently republished as a chapter of his book (2002, pp. 419-451), where he accuses Marxist dialecticians of not tolerating criticism. Ironically, Popper’s view that all Marxist dialecticians dogmatically dismiss any criticism of dialectic by claiming that their opponents do not understand dialectic makes his position no less dogmatic. Indeed, any attempt to criticise Popper’s views on dialectics would be seen only as an additional example of responses by “dogmatic dialecticians”, making his theory essentially immune. This completely prevents dialecticians from being able to criticise Popper’s views. This is exactly the opposite of what the great philosopher wanted. Therefore, for the sake of “antidogmatic science” it is desirable and even necessary to defend dialectic. In this work I address several central points about Popper’s criticism of Marxist (materialist) dialectic. In particular, I (a) analyse Popper’s definition of dialectic as the dialectic triad (thesis, anti-thesis, synthesis) and contrast it with a notion of dialectic as a much more complex concept which occurs in dialectical materialism today, where the triad represents only one of the aspects; (b) compare dialectic with the trial and error method; (c) discuss the place of dialectic amongst valid scientific methods: Does dialectic accept logical contradictions; (e) discuss lessons dialecticians should learn from Popper’s criticism. I will test my arguments as to their constructiveness and will demonstrate explicitly the nature of my disagreement with Popper thereby trying to avoid the “dogmatic dialecticians” response as much as possible.
Bioresorbable everolimus-eluting vascular scaffold for the treatment of chronic total occlusions: CTO-ABSORB pilot study.

AIMS We sought to assess the safety and performance of the Absorb everolimus-eluting bioresorbable vascular scaffold (BVS) in percutaneous chronic total occlusion (CTO) revascularisation guided by intracoronary imaging. The feasibility of using the BVS in CTO lesions is unknown. METHODS AND RESULTS Thirty-five consecutive true CTO lesions (EuroCTO Club definition) were included in this prospective registry. After mandatory predilatation and IVUS analysis, all target lesions were treated with BVS and no other stents were deployed. Optical coherence tomography (OCT) was performed after BVS implantation. Multislice computed tomography (MSCT) was performed at baseline and at six to eight months. The mean age was 60.7±9.7 years; 80% were male; 20% were diabetic; 37% had a previous PCI. The most frequently treated vessel was the RCA (46%). According to the Japanese-CTO (J-CTO) complexity score, most lesions were classified as intermediate (49%) or difficult-very difficult (26%); 34% were moderate-severely calcified. Most cases (86%) were treated with an anterograde strategy, 60% by radial or biradial approach. In 71% a cutting balloon was used. The total scaffold length implanted per lesion was 52.5±22.9 mm. All scaffolds were successfully delivered and deployed. Post-dilatation was undertaken in 63%. By OCT, final minimum scaffold area and lumen stenosis were 7.1±1.5 mm2 and 11.7±6.6%, without areas of significant strut malapposition. At complete six-month follow-up, no major adverse events were observed. MSCT identified two cases of scaffold reocclusion. CONCLUSIONS BVS for CTO recanalisation demonstrates excellent feasibility and safety as well as midterm efficacy. Appropriate lesion preparation is key to aiding adequate expansion of these scaffolds in this setting.
Pamela, a parking analysis model for predicting effects in local areas

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Handbuch Strassenbau: Grundlagen fuer Ausbildung und Praxis

Das Buch vermittelt in kompakter und zusammenfassender Form die Grundlagen zu dem komplexen Thema "Strassenbau". Es spannt einen Bogen von den ersten Verkehrsuntersuchungen ueber die Planung und den Bau einer neuen Strecke bis hin zur spaeteren Unterhaltung und fasst somit das gesamte Spektrum des Strassenbaus zusammen. Die Inhalte werden verstaendlich und praxisnah behandelt. Das vorliegende Werk bietet Studierenden, Referendaren und Inspektorenanwaertern ebenso wie Praktikern einen umfassenden Ueberblick ueber die verschiedenen Themenfelder des Strassenbaus. Aus dem Inhalt: Grundlagen; Strassenverkehrstechnik; Entwurf; Bauausfuehrung; Baustoffe; Strassenbaumaschinen; Qualitaetspruefung; Strassenbetrieb; Unterhaltung und Instandsetzung; Vertragswesen.
Novel Gait Adaptation and Neuromotor Training Results Using an Active Leg Exoskeleton

The gait of every adult is unique and expected to be ingrained within the neuromuscular system. The major scientific question that we ask in this paper if it is possible to alter the gait of healthy individuals using special purpose design of robots and training paradigms. This paper describes novel experimental results with an active leg exoskeleton (ALEX) and a force-field controller (FFC) developed for neuromotor training of gait and rehabilitation of patients with walking disabilities. ALEX is a motorized leg orthosis having a total of 7 DOFs with hip and knee actuated in the sagittal plane. The FFC applies forces on the foot to help the leg move on a desired trajectory. The interaction forces between the subject and the orthosis are designed to be ¿assist-as-needed¿ for safe and effective gait training. Simulations and experimental results with the FFC are presented. Experiments have been performed on six healthy subjects walking on a treadmill. It was shown that a healthy subject could be retrained in about 45 min with ALEX to walk on a treadmill with a considerably altered gait. In the coming months, this powered orthosis will be used for gait training of stroke patients.
TUMORIGENESIS AND NEOPLASTIC PROGRESSION FAM 190 A De fi ciency Creates a Cell Division Defect

opyright a 2013 American Society for Inve ublished by Elsevier Inc. All rights reserved ttp://dx.doi. org/10.1016/j.ajpath. 2013.03. 020 Like the p16, SMAD4, and RB1 genes, FAM190A (alias CCSER1) lies at a consensus site of homogeneous genomic deletions in human cancer. FAM190A transcripts in 40% of cancers also contain in-frame deletions of evolutionarily conserved exons. Its gene function was unknown. We found an internal deletion of the FAM190A gene in a pancreatic cancer having prominent focal multinuclearity. The experimental knockdown of FAM190A expression by shRNA caused focal cytokinesis defects, multipolar mitosis, and multinuclearity as observed in time-lapse microscopy. FAM190A was localized to the gtubulin ring complex of early mitosis and to the midbody in late cytokinesis by immunofluorescence assay and was present in the nuclear fraction of unsynchronized cells by immunoblot. FAM190A interacted with EXOC1 and Ndel1, which function in cytoskeletal organization and the cell division cycle. Levels of FAM190A protein peaked 12 hours after release from thymidine block, corresponding to M-phase. Slowermigrating phosphorylated forms accumulated toward M-phase and disappeared after release from a mitotic block and before cytokinesis. Studies of FAM190A alterations may provide mechanistic insights into mitotic dysregulation and multinuclearity in cancer. We propose that FAM190A is a regulator or structural component required for normal mitosis and that both the rare truncating mutations and common in-frame deletion alteration of FAM190A may contribute to the chromosomal instability of cancer. (Am J Pathol 2013, 183: 296e303; http://dx.doi.org/10.1016/j.ajpath.2013.03.020)