Miracle-dz/UniFAR-FTUs huggingface dataset:
Health attributes of ten Mediterranean edible flowers: anti-proliferative and enzyme-inhibitory properties

Edible flowers represent an important source of biologically active compounds with positive effects on consumer health. In fact, they contain high quantities of natural antioxidants and have been used since ancient times not only to prepare traditional recipes but also as a remedy against some common illnesses. In the current report, the extracts of ten Mediterranean edible flowers were analyzed to determine their relevant vitamin C, chlorophylls, carotenoids, proanthocyanidins, flavonoids, anthocyanins and total phenolics contents. They were also assayed in vitro for inhibitory effects on digestive enzymes relevant to carbohydrates metabolism and for anti-proliferative activity on CaCo2 colon cancer cell line. Accordingly, the extracts inhibited the a-glucosidase activity in a dose-dependent manner. In addition, half-maximal inhibitory concentration (IC50) ranged from 12.5 ± 1.9 to 132 ± 3.2 mg/mL, while for the anti-proliferative activity IC50 values varied from 24.26 ± 4.5 to 106.3 ± 5.7 mg/mL. In view of the obtained results, the use of these flowers provides important functional ingredients as well as contributing to the realization of delicate and more appealing flavor recipes.
The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic Performance

Intrinsic cardiogenic factor expression, a proxy for cardiomyogenic lineage commitment, may be an important determinant of donor cell cardiac reparative capacity in cell therapy applications; however, whether and how this contributes to their salutary effects remain largely ambiguous. Methods: The current study examined the consequences of enhanced cardiogenic factor expression, via lentiviral delivery of GMT (GATA4, MEF2C, and TBX5), on cardiac mesenchymal cell (CMC) anti-fibrogenic paracrine signaling dynamics, in vitro, and cardiac reparative capacity, in vivo. Proteome cytokine array analyses and in vitro cardiac fibroblast activation assays were performed using conditioned medium derived from either GMT- or GFP control-transduced CMCs, to respectively assess cardiotrophic factor secretion and anti-fibrogenic paracrine signaling aptitude. Results: Relative to GFP controls, GMT CMCs exhibited enhanced secretion of cytokines implicated to function in pathways associated with matrix remodeling and collagen catabolism, and more ably impeded activated cardiac fibroblast Col1A1 synthesis in vitro. Following their delivery in a rat model of chronic ischemic cardiomyopathy, conventional echocardiography was unable to detect a therapeutic advantage with either CMC population; however, hemodynamic analyses identified a modest, yet calculable supplemental benefit in surrogate measures of global left ventricular contractility with GMT CMCs relative to GFP controls. This phenomenon was neither associated with a decrease in infarct size nor an increase in viable myocardium, but with only a marginal decrease in regional myocardial collagen deposition. Conclusion: Overall, these results suggest that CMC cardiomyogenic lineage commitment biases cardiac repair and, further, that enhanced anti-fibrogenic paracrine signaling potency may underlie, in part, their improved therapeutic utility.
DETERMINANT OF E-GOVERNMENT AND GOOD GOVERNANCE :CASE IN THE ACEH PERSONNEL DEPARTMENT

This research is conducted to test the effect among information technology, human resource (HR), organizational culture, e-government and good governance. The object is the Aceh Personnel Department (BKA), and the respondents are the employees of it as much as 127 people that taken by a cencus method. The data is processed by Structural Equation Model (SEM) with AMOS software. The result proves that information technology has a significant effect on e-government; human resources has a significant effect on e-government; organizational culture has a significant effect on egovernment; information technology has a significant effect on good governance; human resources has a significant effect on good governance; organizational culture has a significant effect on good governance, and; e-government has a significant effect on good governance. These research findings have implications that efforts to implement good governance in these institutions can be done through policy interventions related to improving information technology, increasing the quality of employee HR and the implementation of organizational values and culture. These also contribute to the science area that can be an update causality theories related to the variables. This model is able to be a reference for the further research especially in the field of management and organization. The originality lies in the combination of the models fro the previous causality theories, and the test method using SEM. The limitation is in the number of variables and object. Keyword: Information technology, human resource, organizational culture, e-government and good governance.
Triglyceride to high-density lipoprotein cholesterol and low-density lipoprotein cholestrol to high-density lipoprotein cholesterol ratios are predictors of cardiovascular risk in Iranian adults: Evidence from a population-based cross-sectional study

Background: The superiority of TG/HDL-C and LDL-C/HDL-C ratios in predicting CVD risk is a matter of debates. Thus, the objective of this study was to compare TG/HDL-C and LDL-C to HDL-C ratios in predicting the risk of CVD events. Methods: In a population-based cross-sectional study, 567 representative participants aged 40 years or older were entered in the study in Babol, North of Iran. The demographic data, anthropometric measures, and the cardio metabolic risk factors were measured. The individual risk of CVD events was assessed by ACC/AHA risk model. ROC analysis was applied to estimate the diagnostic accuracy and the optimal cut-off points of TG/HDL-C and LDL-C/HDL-C ratios. Results: The AUC of TG/HDL-C and LDL-C/HDL-C ratios were rather similar and both parameters significantly predicted CVD risk in men comparably, and TG/HDL-C at optimal cutoff point of 3.6 produced 75% sensitivity and 39% specificity. However,in women TG/HDL-C with AUC of 0.65( p=0.091) at optimal cutoff value of 3.4 produced a sensitivity of 82% and specificity of 51%. The LDL-C/HDL-C ratio had no discriminative ability in predicting CVD risk in women. The adjusted OR of TG/HDL-C at 2nd quartile was significant (OR=3.22, 95% CI:1.25-8.29) and a greater association was found with 3rd and 4rth quartiles Conclusion: Both TG/HDL–C and LDL-C/HDL-C ratios comparably predict CVD risk in men, whereas in women only TG/ HDL-C is a significant predictor but not LDL-C/HDL-C.
Noncoding RNAs in Vascular Aging

Increases in age are accompanied by vascular aging, which can lead to a variety of chronic diseases, including atherosclerosis and hypertension. Noncoding RNAs (ncRNAs) have become a research hotspot in different fields of life sciences in recent years. For example, these molecules have been found to have regulatory roles in many physiological and pathological processes. Many studies have shown that microRNAs (miRNAs) and long ncRNAs (lncRNAs) also play a regulatory role in vascular aging. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are important components of blood vessels, and the senescence of both cell types promotes the occurrence of vascular aging. This review provides a contemporary update on the molecular mechanisms underlying the senescence of ECs and VSMCs and the regulatory role of miRNAs and lncRNAs in this process.
Polyspermic fertilisation of porcine oocytes in vitro – a current review

Polyspermic fertilisation has been a continual problem in porcine in vitro fertilisation. Over the years, researchers have tried to resolve this persistent problem, but have not been entirely successful in their endeavour. This can be attributed to several factors. This review discusses the role of sperm capacitation in the in vitro fertilisation and the most recent studies on the capacitation media. This includes the results obtained by testing the effect of various compounds on sperm capacitation. Additionally, the importance of the oviductal fluid on the porcine oocytes prior to fertilisation is also discussed. This is of significance, as the experiments show that oviductal fluid is crucial for the pre-fertilisation zona pellucida hardening. Also, the significance of using high quality oocytes for the in vitro fertilisation is highlighted. Lastly, the different and latest techniques to prevent or reduce polyspermic fertilisation have been reviewed.
Analysis and Classification of Motor Dysfunctions in Arm Swing in Parkinson’s Disease

Due to increasing life expectancy, the number of age-related diseases with motor dysfunctions (MD) such as Parkinson’s disease (PD) is also increasing. The assessment of MD is visual and therefore subjective. For this reason, many researchers are working on an objective evaluation. Most of the research on gait analysis deals with the analysis of leg movement. The analysis of arm movement is also important for the assessment of gait disorders. This work deals with the analysis of the arm swing by using wearable inertial sensors. A total of 250 records of 39 different subjects were used for this task. Fifteen subjects of this group had motor dysfunctions (MD). The subjects had to perform the standardized Timed Up and Go (TUG) test to ensure that the recordings were comparable. The data were classified by using the wavelet transformation, a convolutional neural network (CNN), and weight voting. During the classification, single signals, as well as signal combinations were observed. We were able to detect MD with an accuracy of 93.4% by using the wavelet transformation and a three-layer CNN architecture.
Comparison of Antiurolithiatic Property of Orthosiphon Spiralis, Hedychium Marginatum, Thunbergia Alata and Cystone, a Herbal Drug

Kidney is one of the vital parts of the human body. Malfunction of kidney is due to blockage of stone in the urinary tract and urinary infection. Peoples are mainly focused on the treatment of kidney stone by using medicinal plants. Patients suffering from kidney stone may be treated by Lithotripsy, Ureteroscopy, open or Laparoscopy. Such treatment is costly and painful. Now-a- days medicinal plants are mainly used for such treatment because these plants are less side effect and more economic. In the present study, the inhibitory potency of crude extracts of Orthosiphon spiralis, Hedychium marginatum and Thunbergia alata in methanol were evaluated on the formation of calcium phosphate(CP) and on the growth of calcium oxalate monohydrate(COM) crystals in vitro. Also, comparison of antiurolithiatic property of these plants and Cystone, a herbal drug, is studied. Results show that Cystone is effective in the inhibition of CP stone both in aqueous and urinary media while Orthosiphon spiralis has the highest inhibitory effect for COM both in aqueous and urinary media in vitro.
Optimasi Pengendapan Albumin dengan Variasi Suhu, pH dan Konsentrasi Etanol dalam Plasma Darah melalui Metode Simplex Lattice Design Optimization of Albumin Precipitation with Variations in Temperature, pH and Ethanol Concentration in Blood Plasma by the Simplex Lattice Design Method

Albumin is used to treat hypoalbumimenia in various diseases. The utilization of albumin raw materials from donor blood that has exceeded the time limit of use could be advantages, which are reducing dependence on imported albumin and could reduce the cost of processing waste blood. The purity and resulting of albumin can be influenced by various parameters including; temperature, pH and ethanol concentration. In this research, the optimization process is conduct using the Simplex Lattice Design method in order to obtain an optimal composition variation of 7 (seven) parameters variation composition to obtain albumin with a high concentration. Albumin is separated by ethanol fractionation method through differences in protein solubility in plasma. Based on Anova test, the 7 (seven) composition variations of the parameters showed significant differences with p = 0.0282 (<0.05) and F test > Ftable. The evaluation results show that the composition of the 5th composition formula shows the optimal albumin response with temperature parameters -10 °C, pH 4.8 and ethanol concentration of 40%. The albumin content obtained with the composition is 53.59 μg.
Sparse Structured Principal Component Analysis and Model Learning for Classification and Quality Detection of Rice Grains

In scientific and commercial fields associated with modern agriculture, the categorization of different rice types and determination of its quality is very important. Various image processing algorithms are applied in recent years to detect different agricultural products. The problem of rice classification and quality detection in this paper is presented based on model learning concepts including sparse representation and dictionary learning techniques to yield over-complete models in this processing field. There are color-based, statistical-based and texture-based features to represent the structural content of rice varieties. To achieve the desired results, different features from recorded images are extracted and used to learn the representative models of rice samples. Also, sparse principal component analysis and sparse structured principal component analysis is employed to reduce the dimension of classification problem and lead to an accurate detector with less computational time. The results of the proposed classifier based on the learned models are compared with the results obtained from neural network and support vector machine. Simulation results, along with a meaningful statistical test, show that the proposed algorithm based on the learned dictionaries derived from the combinational features can detect the type of rice grain and determine its quality precisely.
ANALYSIS OF PRECIPITATION USING MANN-KENDALL AND KRUSKAL-WALLIS NON-PARAMETRIC TESTS

: e main objective of this research was to verify the long-term rainfall behavior in a location in the Brazilian semiarid region. Century-long monthly precipitation data (1911 to 2017) provided by DNOCS/SUDENE were used in the investigation. ese data were used to determine descriptive statistics at monthly, annual, decadal and climatic scales. Next, nonparametric statistical tests were applied: Mann-Kendall (trend) and Kruskal-Wallis (multiple comparisons), both with a statistical conﬁdence level of 95%. It was observed that 67.8% of annual rainfall (661.4 mm) is concentrated in three months (Feb-Mar-Apr) and that there was no signiﬁcant tendency of monthly and consequently, annual rainfall. e 1930s, 1950s, 1990s, and 2010s were the driest years in the series, showing that the current dry period (2012-2016) is not unexceptional. Although signiﬁcant trends were observed at 1% rainfall increase between 1930-1980 and 1% rainfall decrease from 1960-2000, when the full series was analyzed there was no signiﬁcant trend. For climatologies the diﬀerences were signiﬁcant at 1% when comparing Climate_2 (1958-1987), which was the wettest, with Climate_1 (1928-1957) and Climate_3 (1988-2017). It is concluded that the current climate and decade have had signiﬁcantly less rain, but they are not unique since other decades and/or past climate series have been drier. shows in the semi-aridregion extremely the interposed the two wettest
Non-rigid magnetic resonance image registration for cervical cancer radiation therapy evaluation using hybrid features

Background: A non-rigid cervical magnetic resonance (MR) image registration algorithm combining pixel intensity and local region gradient features was proposed in this study for cervical cancer radiation therapy (RT) evaluation. Materials and Methods: The method was based on the following main steps: (1) each patient was scanned 2 times. The first scan was before internal-beam RT, and second scan was about 3~4 weeks after internal-beam RT. (2) DoG salient points mixed with stochastically sampled points were used as keypoints, and pixel intensity and PCA-SIFT features around them were extracted to build a feature vector for each keypoint. (3) In non-rigid registration process, α-mutual information (α-MI) was used as similarity measure. The method was evaluated by 20 MR images acquired from 10 patients with biopsy-proven squamous cell carcinomas. Results: For cervical cancer, the deformation of tumor and organ between different MR image acquisitions was subject to several errors, including possible mechanical misalignment, respiratory and cardiac motion, involuntary and voluntary patient motion, bladder and bowel filling differences. To minimize these ambiguities, patients filled their bladder before scanning. The proposed hybrid features can effectively catch the bladder and bowel in MR images, and α-mutual information (α-MI) based non-rigid registration can effectively align two long time internal MR images. Conclusion: Non-rigid cervical MR image registration method using hybrid features on α-MI can effectively capture different tissues in cervical MR images. Accurately aligned MR images can assist cervical cancer RT evaluation process.
Audit Committee Attributes and the Reporting Timeliness of Listed Nigerian Firms

Purpose of the article: This study appraised the extent to which audit committee attributes influence the reporting timeliness of listed Nigerian firms. In this light, firm level secondary data were sourced from the financials of 21 randomly selected firms over a 6 year period (2012–2017). Methodology/methods: The ex-post facto research design was the methodological basis of this research. Additionally, both descriptive and inferential statistical techniques were employed to practically analyse the collated data. Diagnostics tests used included the VIF and Breusch Pagan tests and the study’s hypothesis was developed and tested at 0.05 significance level by means of regression analysis. Scientific aim: This research aims to analyse the link between the attributes of audit committees of firms (size, independence and diligence) and the timeliness of financial reporting by obtaining empirical evidence from listed corporate entities in Nigeria. Findings: The results indicate that audit committee attributes (measured by size, independence and diligence) had a significant relationship with financial reporting timeliness among firms in Nigeria. Conclusion: Since the size, independence and diligence of the audit committee was found to have significant influence on the reporting timeliness of firms, we therefore recommend that while firms are continuously monitored to strictly adhere to the guidelines and present stipulated threshold in constituting their respective audit committees; conscious efforts must be made by regulatory bodies to also monitor the compliance levels of firms especially with respect to the level of independence and diligence of the audit committees.
Benthic alkalinity and dissolved inorganic carbon fluxes in the Rhône River prodelta generated by decoupled aerobic and anaerobic processes

Abstract. Estuarine regions are generally considered a major source of atmospheric CO2, as a result of the high organic carbon (OC) mineralization rates in their water column and sediments. Despite this, the intensity of anaerobic respiration processes in the sediments tempered by the reoxidation of reduced metabolites near the sediment–water interface controls the flux of benthic alkalinity. This alkalinity may partially buffer metabolic CO2 generated by benthic OC respiration in sediments. Thus, sediments with high anaerobic respiration rates could contribute less to local acidification than previously thought. In this study, a benthic chamber was deployed in the Rhône River prodelta and the adjacent continental shelf (Gulf of Lion, northwestern Mediterranean) in late summer to assess the fluxes of total alkalinity (TA) and dissolved inorganic carbon (DIC) from the sediment. Concurrently, in situ O2 and pH micro-profiles, voltammetric profiles and pore water composition were measured in surface sediments to identify the main biogeochemical processes controlling the net production of alkalinity in these sediments. Benthic TA and DIC fluxes to the water column, ranging between 14 and 74 and 18 and 78 mmol m−2 d−1, respectively, were up to 8 times higher than dissolved oxygen uptake (DOU) rates (10.4±0.9 mmol m−2 d−1) close to the river mouth, but their intensity decreased offshore, as a result of the decline in OC inputs. In the zone close to the river mouth, pore water redox species indicated that TA and DIC were mainly produced by microbial sulfate and iron reduction. Despite the complete removal of sulfate from pore waters, dissolved sulfide concentrations were low and significant concentrations of FeS were found, indicating the precipitation and burial of iron sulfide minerals with an estimated burial flux of 12.5 mmol m−2 d−1 near the river mouth. By preventing reduced iron and sulfide reoxidation, the precipitation and burial of iron sulfide increases the alkalinity release from the sediments during the spring and summer months. Under these conditions, the sediment provides a net source of alkalinity to the bottom waters which mitigates the effect of the benthic DIC flux on the carbonate chemistry of coastal waters and weakens the partial pressure of CO2 increase in the bottom waters that would occur if only DIC was produced.
CORO : GRAPH-BASED AUTOMATIC INTRUSION DETECTION SYSTEM SIGNATURE GENERATOR FOR E- VOTING PROTECTION

Attacks on computer network are increasing everyday and most institution use Intrusion Detection System (IDS) to cope with that and most used IDS is the signature-based IDS, which need a database of rules when looking for an malicious packet. Yet there are two problems with this kind of IDS, first, not all people are able to create a signature or rule, therefore they need to wait for updates if they want to renew their database. Secondly, zero-day attack, attack that has never been happened before, is the main weakness of this IDS due to absence of its signature. We proposed Coro, an IDS signature generator that create an IDS rules based on honeypot log data. Coro uses graph clustering that make it be able to cluster data without the need to recompute the centroid. Coro focuses on HTTP, as it will be used to harden our e-voting system, but it is possible to be extended to other protocols. Our experiment showed that Coro was able to cluster around 5000 request in a short time and our graph clustering was a big help to that. Moreover, two threshold value used and data preprocessing in that experiment affected amount and quality of the generated rules. Keyword : IDS, Rules Generation, Graph Clustering, E-Voting, Graph Mining
Business Strategy and Enterprises’ Ability of Sustainable Development: Evidence from China

The present study was designed to investigate whether business strategy affects firms’ ability of sustainable development. Using a sample of A-share non-financial publicly listed firms in China, this paper shows that: (1) on average, there is a negative correlation between the choice of radical strategy and the sustainable development ability of enterprises; (2) compared with non-high-tech enterprises, the above relation is more pronounced in high-tech enterprises. The findings are also robust to endogeneity checks and alternative measures of firms’ sustainable development ability. Overall, this study indicates that business strategy plays a fundamental role in enterprise operations, and the choice of radical strategy will weaken the sustainable development ability of enterprises, especially in hightech enterprises. Therefore, this study suggests that in order to improve the sustainable development ability of enterprises, it is necessary to further optimize the strategic choice of enterprises and avoid using too many radical strategic types. Keywords—Business Strategy; Sustainable Development Ability; High-Tech Enterprises