Miracle-dz/UniFAR-FTUs huggingface dataset:
Sound and Form in Modern Poetry

Why are poems important? What do people mean when they use the word prosody? How does a poem read and sound? How does a poem's shape--its form--help to create its meaning? "Sound and Form in Modern Poetry" provides useful answers to these questions for readers of poetry. Through careful attention to the poems of modern masters, the book offers an accessible guide to the way today's poems really work, and to the way they are linked in style to poems of earlier times. Poet, critic, and editor Robert McDowell has updated this classic text in the light of the poetic and critical developments of the last three decades. Segments on Dickinson, Robinson, Frost, Jeffers, and Lowell, among other poets, have been greatly expanded, and Ashbery, Creeley, Ginsberg, Hall, Kees, Kumin, Levertov, Levine, O'Hara, Plath, Rich, Simpson, and Wilbur added, among others. The epilogue discusses a new generation of poets whose works will likely be read well into the next century-- among others, Thomas M. Disch, Rita Dove, Dana Gioia, Emily Grosholz, Mark Jarman, Molly Peacock, Gjertrud Schnackenberg, Timothy Steele, Mary Swander, and Marilyn Nelson Waniek. Over the last ten years, the most inspiring topic of conversation and argument among poets and their readers has been the resurgence of narrative and traditional forms. The new "Sound and Form in Modern Poetry" is a seminal text in this discussion, examining not only this movement but all of the important developments (Dadaism, Surrealism, Imagism, Language Poetry, and the Confessional School) that have defined our poetry in the twentieth century and have set the stage for poetry's continued life in the twenty-first. The original "Sound and Form in Modern Poetry" enjoyed extensive classroom use as a text; the revised version promises to be even more accessible, and more essential, for years to come. The late Harvey Gross was Professor of Comparative Literature, State University of New York at Stony Brook. Robert McDowell is publisher and editor of Story Line Press, and is also poet, critic, translator, fiction writer, and essayist.
Genomic markers of early progression on fulvestrant with or without palbociclib for ER+ advanced breast cancer in the PALOMA-3 trial.

1010 Background: Markers of early progression on endocrine therapy in combination with CDK4/6 inhibitors remain limited despite the key role of these combinations in treating of ER+ advanced breast cancer (ABC). We investigated genomic aberrations in patients treated with fulvestrant, with and without palbociclib, with a circulating tumor DNA analysis of baseline plasma in the PALOMA-3 trial. Methods: PALOMA-3 was a phase III trial that randomized 521 patients with ER+/HER2- ABC 2:1 to palbociclib plus fulvestrant (P+F) or placebo plus fulvestrant (F). Using baseline plasma samples, somatic mutations were assessed with a 17 gene panel. Copy number aberrations (CNA) were characterized with a 14 gene panel including ~800 SNPs in 8 commonly altered regions for estimation of tumor purity, the percentage of plasma DNA that was derived from tumor cells. Results for mutations and CNAs were available in 310 pts (203 P+F, 107 F) and were associated with clinical characteristics and progression free survival (PFS) using univariable and multivariable Cox proportional hazards models, including tumor purity and treatment as variables. Results: In the multivariable analysis of the whole cohort, higher baseline tumor purity in plasma was associated with worse PFS (HR 1.20, 95% CI 1.09 – 1.32, p = 0.0001, HR per 10% increase in purity). Baseline TP53 mutation was also associated with shorter PFS (HR 1.84, 95%CI 1.27 – 2.65, p = 0.0011), as was baseline FGFR1 amplification (HR 2.91, 95%CI 1.61 – 5.25, p = 0.0004). PIK3CA and ESR1 mutations had no significant association with PFS in the multivariable model. Palbociclib treatment effect was comparable with the overall trial result (HR 0.43, 95%CI 0.32 - 0.57, p < 0.0001). TP53 mutations were significantly associated with visceral (q = 0.046) and soft tissue/LN metastases (q = 0.042) and the number of disease sites (q = 0.0086) after correction for multiple testing. Conclusions: TP53 mutation, FGFR1 amplification , and tumor purity in plasma identified patients at risk of early progression In PALOMA-3. If validated these results could inform future clinical trials of CDK4/6 inhibitors combinations.
Study on 3PL Logistics Firms Service Management

Competing on service is an absolute must in today’s business environment. The globalization of business and the increase in competitive pressures have prompted many firms to develop logistics as a part of their corporate strategy for cost and service advantages, To fully satisfy the increasing requirements of customers for one-stop services, many logistics service providers (LSPs) have taken initiatives to broaden the scope of their services in P.R. China, Based on surveyed ,we found out industry firms hope the third party logistics(3PL) to reduce logistics costs and provide integrated logistics services, 3PL could make logistics strategy to satisfy customers requirements.
Identification of EMG activity with machine learning in patients with amputation of upper limbs for the development of mechanical prostheses

A study of electromyographic signals (EMG) in subjects with partial hand amputation using machine learning techniques (ML) is presented in this document. The EMG were analyzed for five hand poses. We used the Fast Fourier Transform (FFT), and Wavelet transform as descriptors for the feature extraction, the identification and classification system was implemented based on Vector Support Machines (VSM). Percentages of accuracy greater than 90% were obtained in the cases of close hand, left hand, right hand and relax hand, while open hand obtained an acceptable performance with accuracy percentages lower than 90%.
Back pain in the young: a review of studies conducted among school children and university students

Back Pain [BP] represents one of the most common occupational disorders among human beings, with almost all people experiencing it at some stage during their life. Despite the well-known relationships between workplace factors and BP among adults, BP also affects younger people, such as school children and university students. Although some evidence suggests an increasing prevalence of BP throughout later childhood, it is difficult to ascertain whether this reflects a true increase in prevalence, or just greater recognition of the problem by researchers and research subjects. Nevertheless, various studies have begun to highlight a variety of BP risk factors in young people, such as classroom posture, backpacks, computer usage and psychosocial factors. As today’s school children and university students may be a generation increasingly burdened by BP, it is essential that clinicians in the paediatric field keep abreast of contemporary issues and risks, so that they may more effectively deal with this growing menace.
The population structure of wild Scottish brown trout (Samo trutta L.1758) of Loch Maree, Wester Ross: spatial genetic distribution after population decline

The wild trout of Loch Maree is an understudied population that recently experienced a population decline after once having a world status for its sea trout fisheries. Tissues and specimens sampled over the last decade exist in archives and have yet to undergo population genetic analysis. This study aims firstly to determine the best approach to characterising the genetic structure of the Salmo trutta population of Wester Ross with the available archived tissues/specimens. The population structure observed will then be analysed so as to examine the effects of the Wester Ross geography and topography upon the trout population’s genetic diversity. Nine markers from the Beaufort Trout MicroPlex microsatellite panel were used to genotype 192 Salmo trutta samples sampled across 35 sites within Loch Maree and neighbouring catchments, split into four major resident regions: NW-, CW- and SE Loch Maree, and Gairloch, as well as sea trout from the Ewe and Flowerdale systems. Results suggest the population genetics of brown trout in Wester Ross are structured at regional and river scales, and suggests a genetic bottleneck caused by the population decline is still detectable. “Within-population” genetic diversity seems similar between regional populations sampled. Differences observed in population allele frequencies suggest the Gairloch and NW Loch Maree populations are the most similar regional populations analysed, with significant departures from Hardy-Weinberg equilibrium in almost all their loci, suggesting they may be under significant environmental pressure. The Wester Ross sea trout seem to be an admixture of the resident trout populations, with overlapping coastal ranges. Headwater populations have reduced genetic diversity compared downstream which may be influenced by genetic drift in isolation caused by barriers such as waterfalls and dams. A positive correlation was also observed between geo-hydrological distance and genetic divergence within regional resident trout populations, with a degree of introgression between all populations that are hydrologically connected. The analysis also suggest Loch Maree was likely colonised initially at the NW point by ancient migrant sea trout rather than a freshwater-radiation from an inland glacial refuge since the retreat of the last glacial maximum.
Estimation of Single Leaf Area of Acacia mangium Willd

The objective of this study was to determine the best equation for estimating the leaf area of ​​Acacia mangium Willd. from the linear dimensions of the leaflets of non-destructive form. For this, 476 leaflets of plants belonging to Lajeado farm were collected in the municipality of Ecoporanga, in the north of the State of Espírito Santo, Brazil. From each leaflet was determined the length (L) along the main midrib, the largest width (W), the product of the multiplication between the length and the width (LW) the observed leaf area (OLA). For the modeling, we used 382 leaflets in which OLA was the dependent variable in function of L, W or LW as independent variable, being adjusted the linear models of first degree, quadratic and power. For the validation, the values ​​of L, W and LW of 94 leaflets were replaced in the equations obtained in the modeling thus obtaining the estimated leaf area (ELA). The means of ELA and OLA were compared by Student's t test at 5% probability. It was also determined the mean absolute error (MAE), the root mean square error (RMSE) and Willmott's index d. In order to select the best equation, the following criteria were used: : not significant of the comparison of the means of ELA and OLA, values ​​of MAE and RMSE with closer to zero and index d closer to one. The power model equation represented by is the most adequate to predict the leaf area of ​​Acacia mangium Willd. quickly and non-destructively.
Association of STK11/LKB1 genomic alterations with lack of benefit from the addition of pembrolizumab to platinum doublet chemotherapy in non-squamous non-small cell lung cancer.

102 Background: Addition of pembrolizumab (P) to platinum-doublet chemotherapy [carboplatin (or cisplatin) and pemetrexed (CP)] prolongs overall survival and is a standard of care (SOC) for the 1st line treatment of metastatic EGFR/ALK wild-type (wt) non-squamous non-small cell lung cancer (mnsNSCLC). Despite widespread adoption of the CPP regimen, molecular determinants of clinical benefit from the addition of P to CP remain poorly defined. We previously identified genomic alterations in STK11/LKB1 as a major driver of primary resistance to PD-1/PD-L1 blockade in mnsNSCLC. Here, we examine the impact of STK11/LKB1 alterations on clinical outcomes with CPP chemo-immunotherapy. Methods: 497 pts with mnsNSCLC and tumor genomic profiling encompassing STK11/LKB1 from 17 academic institutions in the US and Europe were included in this study. Clinical outcomes were collected for two distinct patient cohorts: a) 377 pts treated with first-line CPP (or > 1st line following FDA-approved TKIs) that were alive for 14 days thereafter and b) 120 STK11/LKB1-mt pts that received CP prior to regulatory approval of CPP. Results: Among 377 CPP-treated pts, STK11/LKB1 genomic alterations (N = 102) were associated with significantly shorter PFS (mPFS 4.8m vs 7.2m, HR 1.5, 95% CI 1.1 to 2.0; P = 0.0063) and shorter OS (mOS 10.6m vs 16.7m, HR 1.58, 95% CI 1.09 to 2.27; P = 0.0083) compared with STK11/LKB1-wt tumors (N = 275). ORR also differed significantly between the two groups (32.6% vs 44.7%, P = 0.049). Similar results were obtained when limiting the analysis to EGFR and ALK-wt tumors (N = 333). Importantly, in pts with STK11/LKB1-mt mnsNSCLC, addition of pembrolizumab to CP did not improve PFS (mPFS 4.8m vs 4.3m, HR 1.13, 95% CI 0.83 to 1.54, P = 0.75) or OS (mOS 10.6m vs 10.3m, HR 1.03, 95% CI 0.71 to 1.49, P = 0.79) compared to CP alone. Conclusions: In mnsNSCLC, STK11/LKB1 alterations define a subgroup of pts with inferior clinical outcomes with CPP and lack of benefit from the addition of pembrolizumab to CP chemotherapy. Novel therapeutic strategies are required to establish effective antitumor immunity in STK11/LKB1-mutant NSCLC.
A Comparison of Hamstring and Quadriceps Muscular Work and Power in Elite Karate Athletes before and after Fatigue

Purpose: The rate of performed work by most muscles is rarely constant with time. Because of rapid time-course changes, it has been necessary to calculate muscle power as a function of time. The aim of the present study was to assess the differences in Hamstring and Quadriceps muscular work and power in elite karate athletes before and after fatigue in order to identify injury risk factors. Methods: Fourteen female elite karate athletes (15.5±1.3 years) were evaluated using isokinetic dynamometer at 60◦/s, 180◦/s and 300◦/s before and after Hamstring and Quadriceps muscular fatigue. Results: No differences were found in Hamstring and Quadriceps muscular power before and after fatigue at the 180◦/s speed (p> 0.05). At 180◦/s speed, the Hamstring presented no differences in muscular work after fatigue muscular test (p<0.05). At the 60 and 300◦/s speeds, Hamstring and Quadriceps muscular power presented a lower power after fatigue test (p=0.04). Conclusion: Based on the present results, fatigue does not have a significant effect on power and the work done by karate athletes' muscles around knee joint at medium speed however, generally, fatigue probably causes imbalance in mechanical power and work done by hamstring and quadriceps at other angular
Scribble and Discs-large direct adherens junction positioning and supermolecular assembly to establish apical-basal polarity

Apical-basal polarity is a fundamental property of animal tissues. The Drosophila embryo provides an outstanding model for defining mechanisms that initiate and maintain polarity. Polarity is initiated during cellularization, when cell-cell adherens junctions are positioned at the future boundary of apical and basolateral domains. Polarity maintenance then involves complementary and antagonistic interplay between apical and basal polarity complexes. The Scribble/Dlg module is well-known for promoting basolateral identity during polarity maintenance. Here we report a surprising role for the Scribble/Dlg module in polarity initiation, placing it at the top of the network that positions adherens junctions. Scribble and Dlg are enriched in nascent adherens junctions and are essential for adherens junction positioning and supermolecular assembly. They also play a role in basal junction assembly. We test hypotheses for the underlying mechanisms. Our data suggest that the Scribble/Dlg module plays multiple roles in polarity initiation, via Par-1-dependent and independent mechanisms. Different domains of Scribble contribute to these distinct roles. Together these data reveal novel roles for Scribble/Dlg as master scaffolds regulating the assembly of distinct junctional complexes at different times and places.
HYPERTENSIVE CRISES: PP.14.40

Objectives: Clinical diagnosis of hypertensive crises (hypertensive emergencies and urgencies) has to be established to offer proper treatment. Design and Methods: Data from the literature are reviewed to give expert views on the clinical diagnosis, differential diagnosis and pharmacological treatment of hypertensive crises. Results: Hypertensive emergencies are those conditions with critically elevated BP (SBP>200, DBP>120 mm Hg) and evidence of acute target organ damage (hypertensive encephalopathy, acute MI, pulmonary edema, dissecting aortic aneurysm, intracerebral hemorrhage, subarachnoid hemorrhage, acute ischemic stroke, eclampsia, acute renal failure, phaeochromocytoma, vasculitis and clonidine withdrawal). In hypertensive emergencies critically elevated BP should be lowered rapidly within 15–30 min. to avoid and limit the risk of serious complications, but controlled (reduction of mean arterial pressure by 25%, aim DBP100–110, SBP 160 mm Hg) to avoid sudden drop of BP and following reduction of perfusion to vital organs (brain, heart). Initial medical treatment depends on the clinical presentation and will be discussed in details. Hypertensive urgencies are those conditions with critically elevated BP (SBP >200, DBP >120 mm Hg) without evidence of acute target organ damage but with at least one of the following clinical presentations: TIA, CHF, IHD, perioperative HTN, status post renal transplantation, severe diabetic retinopathy. In hypertensive urgencies critically elevated BP should be lowered gradually within hours but controlled (aim DBP 100–110 mm Hg, SBP 160 mm Hg). Not every elevation of SBP > 200 and DBP >120 mm Hg is automatically a hypertensive emergency or urgency. Differential diagnosis has to be considered: severe HTN without organ damage (hypertensive situation, pseudoemergency), and malignant HTN. Conclusions: Proper clinical diagnosis and differential diagnosis of hypertensive crises are essential to offer adequate treatment and to avoid unnecessary und possible risky treatment.
The 'dark side' of tamoxifen : understanding adverse cellular response to endocrine therapy in ER+ breast cancer

Background: Endocrine resistance is a common problem in estrogen receptor positive (ER+) breast cancer, particularly in the advanced setting. Beyond the anticipated effects of endocrine resistance, recent evidence points towards some ER+ cancers exhibiting a counterintuitive, adverse response to endocrine treatments, particularly in the setting of E-cadherin deficiency. Here the effects of adverse cell response to endocrine therapy is explored, including responsible cellular mechanisms. The ER co-receptor PELP-1, found to be of importance in mediating a pro-invasive response to endocrine treatments, was further explored in relation to its function in ER+, as compared to triple negative breast cancer (TNBC). Methods: The effects of endocrine treatments on the proliferative and invasive/migratory capacity of ER+ and TNBC cells, in the presence or absence of functional E-cadherin and/or PELP-1, were determined using cell counting and trans-well Boyden chamber-based assays respectively. For TNBC cells, studies were extended into 3D culture models. Mechanistic studies on endocrine-mediated modulation of cell signalling were determined by Western blotting. Results: Tamoxifen and fulvestrant induced a pro-invasive/pro-migratory phenotype in ER+ MCF-7 cells that displayed a high basal expression of PELP-1. This effect was augmented in the setting of E-Cadherin suppression and regulated in a Src-dependent manner. In contrast, no adverse phenotype was observed with cells cultured in estrogen-deprived conditions. PELP-1 suppression reduced endocrine-induced invasion/migration in MCF-7 cells, whilst PELP-1 knockdown in TNBC cells inhibited endogenous invasion in 2D and 3D culture. Conclusion: ER-targeting anti-estrogens may be responsible for inducing an adverse cell phenotype in ER+ breast cancers that highly express PELP-1; this effect may be more apparent in tumours that are also E-cadherin deficient. Such tumours may benefit from treatment with aromatase inhibitors as opposed to ER-targeting agents. PELP-1 may be an important target for future therapy, and act as a biomarker, predicting response to treatment in ER+ and TNBC.
Management of daily physical activity and diabetic foot prevention

Even if physical activity plays a key role within diabetic foot treatment its use and the results obtained from this treatment seem to be still limited. Nowadays, new and even more advanced technologies for the long term daily physical activity monitoring are available and they are radically changing some aspects of physical activity such as its amount, features and monitoring. In spite of the past, the several electronic devices that are currently available can be integrated into routine care and provide essential information for management to both the healthcare providers and patients. In particular, since the end of the last century, an increasing number of studies have applied the movement monitoring to patients at risk or with history of ulceration. The questionnaires have been progressively replaced with modern technologies such as accelerometers or complex multisensory devices able to objectively measure the physical activity performed. The data collected through the use of such devices can allow a better assessment of patient’s condition and provide useful information for the definition of a more complete treatment protocol. Daily physical activity monitoring devices provide to the Diabetes Units information on the typology, quantity, distribution and intensity of the daily physical activity performed by each patient concurring to the prevention of foot ulcers that represent the most dreadful diabetes complications. The different functions and modes of operation of monitoring devices can be integrated to provide a more comprehensive and intelligent monitoring system that provide valuable information on patients’ ongoing health status and the physical activity performed during daily life. These devices can manage in real time or even in remote the physical activity performed in addition to calculate that to be performed in the following hours. As a result, they contribute to improve patients’ lifestyle and reduce the costs for the treatment of such complications. The aim of this review is to define and emphasize the role of a long term daily physical activity monitoring in the prevention of diabetic foot ulcers.