Miracle-dz/UniFAR-FTUs huggingface dataset:
State of the Art of Friendly “Green” Scale Control Inhibitors: A Review Article

Scale deposition is a difficulty encountered with water containing ions of sparingly soluble salts. A widely used technique for controlling scale deposition is by dosage of an antiscalant. Large quantities of polymeric scale inhibitors are used for scale control in cooling water systems, water desalination processes, and oil field operations. Like most conventional polymers, scale inhibitors are built for long existence and persist for many years after their disposal. Increasing environmental concern and discharge limitations have caused scale-inhibitor chemistry to move toward “green antiscalants” that readily biodegrade, have low mobility for minimum environmental impact, and are cost-effective. This review summarizes efforts to develop cost-effective ecologically benign scale inhibitors. Currently, the most promising green scale inhibitors are based on poly(aspartic acid). However, field operation data are very limited, and widespread use of poly(aspartic acid) scale inhibitors awaits field operation e.
Anti- Toxoplasma gondii effect of Lumefantrine in vitro and in vivo

Background: Toxoplasma gondii is an obligate intracellular protozoan parasite, which can infect almost all warm-blooded animals, including humans, leading to toxoplasmosis. Currently, the effective treatment for human toxoplasmosis is the combination of sulfadiazine and pyrimethamine. However, both drugs have serious side effects and toxicity in the host. Therefore, there is an urgent need for the discovery of new anti-Toxoplasma drugs with high potency and less or no side-effects. Methods: The cytotoxicity of sulfadiazine and lumefantrine to Vero cells was evaluated by the methyl thiazolyl tetrazolium (MTT) assay. And MTT assay was also used to detect the inhibitory effects of lumefantrine on parasites invasion and proliferation. Flow cytometry was conducted to further verify parasites proliferation. qPCR was performed to evaluate the parasite load in the mice after lumefantrine treatment. In order to determine whether lumefantrine treatment enhances Th1 or Th2 cytokine response, IFN-γ, IL-4, and IL-10 levels in the serum of mice were determined. Results: Our findings suggest that lumefantrine exerts activity against T. gondii by inhibiting its replication and invasion of Vero cells in vitro without being toxic to the cells. Furthermore, lumefantrine protected mice with acute toxoplasmosis from death to a certain extent and reduced the parasite burden in mouse tissues in vivo. In addition, a significant increase in IFN-γ production was observed in high dose lumefantrine-treated mice while IL-10 and IL-4 levels increased in low dose lumefantrine-treated mice. Conclusions: The results of this study demonstrated that lumefantrine may be a promising agent to treat toxoplamosis, and more experiments on the protective mechanism of lumefantrine should be undertaken in further studies.Key words: Toxoplasma gondii, Lumefantrine, anti-Toxoplasma gondii, Invasion, Proliferation
A study on the popularity of handmade products among consumers

The focus of this study was toexamine the popularity of handmade products among consumersthrough a survey. We shed light on the effect of the socio-demographic factorssuch as agender identity, age, education, and income level,onconsumer behavior (frequency of purchase, purchase considerations, most popular place of purchase),and consumer demand. The results point out that handmade products are becoming increasingly popular. The surveyed consumers chose high-quality food, which can be beneficial for the manufacturers of handmade products. Hence, we suggest that providing local services and products can be an ideal opportunity to generate income in rural regions. Since only 51 people were surveyed,we are aware that our work cannot be representative,and further data collectionand analysisareplanned for future work.
Reliability components of the WAMS information network

Power system modes can be controlled by use of a wide-area monitoring and control system (WAMS). It is based on the phasor measurement units (PMUs), connected by an infor-mation network covering a significant territory. The functioning reliability of such a network deter-mines to a big extend the correct operation of the entire monitoring system. To assess its reliability, the one can be decomposed conveniently into four components: hardware or technical reliability, traffic reliability, software reliability, resistance to external negative impact on the transmitted in-formation, and to consider each m independently. In this paper, the main attention is paid to as-sessment of the reliability and availability of the first three components in the information network.
Superoxide dismutase, glutathione peroxidase and catalase activities in patients with viral hepatitis C

Purpose: Aerobic organisms possess antioxidant defense systems that deal with reactive oxygen species (ROS) produced as a consequence of aerobic respiration and substrate oxidation. It is considered that free radicals, lipid peroxidation and antioxidant defense play a role in various tissue damages, just as in certain types of viral hepatitis. Materials and methods: We determined SOD, CAT, GPX activities of 18 HCV subjects and matched their values with that of 18 healthy volunteers as control. The patients were diagnosed by physicians on the basis of detailed clinical history, clinical examination and other relevant biochemical investigations. Results: SOD, CAT and GPX activities in patients with HCV were found as (mean±SD) 2.75±0.75 U/mg prot, 19.25±3.4 U/g Hbx10 4 , 78.25±23.23 U/g Hb respectively, whereas for the control group 3.76±1.53 U/mg prot, 13.71±1.6 U/g Hbx10 4 , 63.26±6.9 U/g Hb were observed for the respective enzymes. Conclusion: Our results show the mild impact of hepatitis C on antioxidant status of the person. There is a reduction in SOD level but an increase in CAT and GPX levels. In this study also suggests some possible role of oxidative stress in the mechanism of liver injury during viral hepatitis.
Novel Multifunctional Dual-Band Coupled-Line Coupler With Reuse of Low-Frequency Trans-Directional and High-Frequency Contra-Directional Functions

In this brief, for the first time, a novel multifunctional dual-band coupled-line (CL) coupler with reuse of low-frequency trans-directional (TRD) and high-frequency contra-directional (CTD) functions is presented. It is composed of three cascaded CLs with an overall electrical length of 90° and four shunt capacitors, which achieves a compact circuit configuration in microstrip implementation. Since capacitors are shunted between the CLs, the coupler is easy to realize tight coupling with miniaturized size and has an inherent feature of dc blocking. Moreover, different power ratios can be realized over two designated frequencies. Frequency conversion leads to the location change of the isolation port, which eventually leads to the reuse of the circuit and port function expansion of the coupler. Good agreements between the simulated and measured results verify the design theory.
The Effect of Lactoacidophilus Probiotic on Duration of Physiologic Jaundice in Neonates with 37-42 Weeks Gestational Age: A Randomized Clinical Trial

Introduction & Background: According to socioeconomic burden of neonatal jaundice, it is important to provide interventions that reduce the severity and duration of treatment. Given the ease of probiotics usage; the aim of this study was to determine the effect of probiotics on the level of bilirubin and during hospitalization due to physiological jaundice in term neonates. Methods: The present study was a randomized clinical trial study performed in Kamali Hospital, Alborz Province, Iran, which has the most equipped neonatal intensive care unit. The study samples were all neonates with 37-42 weeks gestational age hospitalized in neonatal intensive care unit and neonates with physiologic jaundice referred to the hospital up to 5 days after birth. Sampling was based on availability and randomized using a randomized number table. the intervention group received lactosacidophilus probiotic with milk two time per day in addition to phototherapy; And the control group was treated only with phototherapy. the bilirubin of both groups was checked daily and written in a table ; Finally, bilirubin level at admission and discharge time and also duration of hospital stay in both groups were compared using SPSS software. Results: There was no statistically significant difference between demographic characteristics in the control and Intervention groups. The results showed that there was no statistically significant difference between two group bilirubin level mean at discharge and hospitalization time (p=0.68). The Mann-Whitney test showed that the length of stay in the hospital was 0.7day shorter in the Intervention group and this difference was statistically significant (p=0.002). Conclusion: use of Lactobacillus bifidus Probiotic reduces hospital stay duration in neonates with physiological jaundice but has no effect on bilirubin level.
COMPUTATIONAL MODELING OF BLOOD FLOW IN THE BIFURCATION OF HUMAN CAROTID ARTERY

: Computational simulations can be used to better predict the risk of atherosclerotic plaques (atheromas) formation. The study presents three-dimensional patient specific computational models of blood hemodynamic in the human carotid arteries based on finite volume method. The geometry of the arteries was created from computer tomography (CT) images. Measured mass flow rate waveform at the inlet and two-element Winkessel model at the outlets are used as boundary conditions. Blood is considered as a non-Newtonian fluid described by Carreau model and pulsating blood flow is solved by transient analysis. Time history of wall shear stress magnitude, velocity profiles in individual cross-sections and flow pattern are evaluated and discussed as they may be helpful in assessing the risk of potential development of atheroma.
The novel MET inhibitor, HQP8361, possesses single agent activity and enhances therapeutic efficacy of osimertinib, against NSCLC cells with acquired resistance to osimertinib due to MET amplification

Background The oncogenic protein, MET (or c-MET), is involved in the positive regulation of cell survival and proliferation and in mediating acquired resistance to EGFR-TKIs including AZD9291 (osimertinib). Thus, MET inhibition is a promising strategy for overcoming acquired EGFR-TKI resistance due to MET amplification. HQP8361 (MK8033) is a novel and selective MET kinase inhibitor that has completed a phase I clinical trial. The current study focuses on determining the activity and mechanism of action of HQP8361 as a single agent and in combination with AZD9291 against human NSCLC cells, particularly EGFR-mutant NSCLCs with acquired resistance to AZD9291. Methods Drug effects on cell growth in vitro were evaluated by measuring cell number alterations and colony formation and in vivo with mouse xenogtaft models, respectively. Apoptosis was assessed with annexin V/flow cytomentry and protein cleavage. Protein alterations were detected with Western blotting. Protein degradation was determined by comparing protein half-lives and inhibiting proteasome. Gene overexpression and knockout were achieved with lentiviral infection and CRISPR/Cas9, respectively. Significance of differences between two tested groups was analyzed with two-sided unpaired Student's t tests. Results The majority of human NSCLC cell lines tested, including those harboring EGFR-activating mutations with acquired resistance to AZD9291, had very low or undetectable levels of MET and p-MET and were insensitive to HQP8361. However, AZD9291-resistant (AR) cell lines derived from the EGFR-mutant HCC827 cell line possessed high levels of MET and p-MET and responded to HQP8361 single agent and particularly to the combination of HQP8361 and AZD9291. The HQP8361 and AZD9291 combination synergistically decreased the survival of these HCC827/AR cell lines with enhanced induction of apoptosis that involved alteration of Bim and Mcl-1 levels via modulating their degradation. Moreover, the combination also very effectively inhibited the growth of HCC827/AR xenografts in nude mice. Conclusions These preclinical findings support the potential of HQP8361 in the treatment of NSCLCs with MET amplification or highly activated MET protein and, when combined with AZD9291, in overcoming acquired resistance to EGFR-TKIs due to MET amplification.
GESTÃO DO CONHECIMENTO E SUCESSÃO EMPRESARIAL: COMBINAÇÃO DE MODELOS PARA EFETIVAÇÃO DA GESTÃO ESTRATÉGICA EM UM ESTUDO DE CASO / KNOWLEDGE MANAGEMENT AND BUSINESS SUCCESSION: A COMBINATION OF MODELS FOR EFFECTIVE STRATEGIC MANAGEMENT IN A CASE STUDY

Strategic management is based on the fundamentals of knowledge management for its effectiveness and suffers losses during succession processes. In this sense, it starts from the case study in a federation to identify how knowledge management influences the process of business succession, aiming to propose a Succession Model, considering the influences of Knowledge Management, for a more effective process, based on the case study of the Federação Maranhense de Empresas Juniores. For that, an exploratory case study was carried out with qualitative purposes, supported by an in-depth interview with the company's management with content analysis to present results. The proposed model is based Brazilian Journal of Development Braz. J. of Develop. , Curitiba, v. 6, n.12, p.101102-101121 dec. 2020. ISSN 2525-8761 101103 on the Nonaka and Takeuchi Knowledge Management Models (2008), Wiig (1993) and Von Krogh and Ross (1994), aligning themselves stages of business succession.
Banking Networks and Economic Growth: From Idiosyncratic Shocks to Aggregate Fluctuations

The objective of this paper is to explore the transmission of non-capital shocks through banking networks. We develop a methodology to construct non-capital (real) shocks, idiosyncratic shocks, using labor productivity shocks to large firms. We document a change in the relationship between (foreign) idiosyncratic shocks in state j and (domestic) economic growth in state i between 1978 and 2000 wherein the relation changes from positive to negative over this period. We show that the contemporaneous changes in banking integration across states is a key driver of this phenomenon. This is driven by geographically diversified banks diverting funds away from economies experiencing negative shocks towards other unaffected economies. This result operates through changes in bank loan supply. Our instrumental variable estimates suggest that a 1% increase in the bank loan supply is associated with a 0.05-0.26 pp increase in economic growth. Lastly, we argue that this mechanism can explain the decrease in the covariance of state-level fluctuations, potentially explaining the Great Moderation, the period of relatively low aggregate volatility.
Daytime Functioning in People with Type 2 Diabetes and Insomnia Symptoms: A Comparison-Correlational Study

Background Sleep disturbances showed negative impact on self-care and diabetes outcomes for people with type 2 diabetes. However, there is a need to understand to what extent insomnia symptoms impact daytime functioning in people with type 2 diabetes. This study compared common daytime functioning outcomes including fatigue, daytime sleepiness, and quality of life related to vitality and physical function in people with type 2 diabetes with and without insomnia symptoms. Methods This study was a cross-sectional comparison design which used validated instruments to assess common daytime functioning outcomes (i.e. fatigue severity scale, daytime sleepiness, and quality of life related to vitality and physical function domains) in 60 participants with type 2 diabetes with and without symptoms of insomnia. Insomnia Severity Index was used to stratify participants into an insomnia group and non-insomnia control group. Multivariate linear model and partial correlations tests were utilized to examine the relationships between outcomes in the two groups after controlling for age and depression symptoms. Results Levels of fatigue severity, and quality of life related vitality and physical function were worse in the insomnia group compared to non-insomnia group (P<.004). After controlling for age, the multivariate linear model showed that the insomnia group had greater fatigue severity (R 2 =0.15, p=.003), and lower quality of life related to vitality and physical function (R 2 =0.25, p<.001; and R 2 =0.11, p=.004, respectively). Partial correlation showed that daytime sleepiness was correlated with Insomnia Severity Index in the full sample after controlling for age ( r =.35, p =.006). When added depression symptoms into the models, the differences or relationships were not observed. Conclusion Fatigue, and quality of life related vitality and physical function were worse in people with both type 2 diabetes and insomnia symptoms compared to people with type 2 diabetes only. Depression symptoms may have an independent contribution for the daytime functioning.
Evaluation of Oxidant and Anti-Oxidant Activity in Rheumatoid Arthritis Patients and Their Effects on Rheumatoid Arthritis Disease Activity

BackgroundRheumatoid arthritis (RA) is the most common cause of systemic inflammatory arthritis which causes joint destruction. The pathogenesis of RA is not fully understood, but it seems imbalance between oxidant and antioxidant process, plays a significant role on it. As a result, suppression of these mechanisms would be helpful to subside inflammation and eventually control of the disease activity. The aim of this study was to evaluate the level of oxidant and antioxidant and their effects on disease activity in RA patients.MethodsIn the following case-control study, we evaluated the levels of Malondialdehyde (MDA) and oxidized Low-Density Lipoproteins (ox.LDL) as oxidative factors and Catalase (CAT), Glutathione Peroxide (GSH-Px) and Superoxide Dismutase (SOD) as antioxidants. Also tumor Necrosis Factor (TNF)-α, Interleukin (IL) 1β and IL6 were measured as inflammatory factors.Results43 RA patients and 43 healthy people were enrolled. Significant differences were found in the average levels of MDA, ox.LDL, CAT, GPX, SOD, TNFα, IL1beta and IL6 between two groups (p-value < 0.001), but we did not find any significant differences between two groups of patients based on DAS28 (p- value> 0.05). ConclusionThe results of our study showed that there were increased oxidative activities in RA patients in comparison to the control group which indicated the presence of inflammatory process causing cellular damage in the patients group. As a consequence, adding some antioxidant agents to RA treatment might have some advantages for the disease control. Based on our findings, it seems that the oxidative process did not have any effect on the disease severity. We also suggest further observational study to confirm the results.
Guaiane sesquiterpenes of Curcuma wenyujin

Objective To study the chemical constituents of the rhizome of Curcuma wenyujin Y.H. Chen et C.Ling. Methods The chemical constituents were isolated by a combination of silica gel,sephadex LH-20,ODS chromatography and HPLC.The structures of these compounds were identified by the physico-chemical evidences and NMR spectroscopic data.Results Seven guaiane sesquiterpenes were isolated from the rhizome of C.wenyujin and identified as zedoarondiol(1),isozedoarondiol(2),aerugidiol(3),zedoalactone A(4),zedoalactone B(5),zedoalactone C(6) and zedoarolide B(7),respectively.Conclusions Compounds 1-7 are obtained from this plant for the first time.
A pandemia por COVID-19 e o paciente idoso: quais as necessidades de atenção em saúde para esse grupo populacional?

Objective: This article aims to address the different facets of the vulnerability of this age group during the COVID-19 pandemic, focusing on the biological, psychological and social impacts of the disease. Methodology: A bibliographic search was performed using the descriptors “SARSCov-2” OR “COVID-19” AND “ELDERLY PATIENT” and the results were grouped according to the themes presented in the articles. Results: Analysis of the published literature on the pandemic demonstrates that policies of social isolation for the elderly need to be aligned with health and social assistance actions to account for the diversity of needs of these patients. Conclusion: It is therefore necessary to maintain the focus on the prevention of COVID-19 combined with other preventive demands on the physical and emotional health of the elderly during pandemics.
RELATIONSHIP BETWEEN TRUNK MUSCLE ENDURANCE, PULMONARY FUNCTION, AND RESPIRATORY MUSCLE STRENGTH IN HEALTHY INDIVIDUALS

Amac: Govde kaslari zorlu ekspirasyon ve govde stabilizasyonunda aktiftir. Bu calismanin amaci solunum kas kuvveti, solunum fonksiyon testi degerleri ve govde kas enduransi arasindaki iliskiyi incelemekti. Yontem: Calisma yaslari 20 ile 36 yil arasinda degisen 60 saglikli gonullu uzerinde yapildi. Olgularin maksimum inspiratuar ve ekspiratuar kas kuvveti (MIP ve MEP) ve solunum fonksiyon testi masaustu spirometre ile degerlendirildi. Bireylerin govde kas enduransi yuzustu kopru, yan kopru, fleksor endurans ve Sorensen testleri ile belirlendi. Sonuclar: Zorlu vital kapasite yuzdesi (%FVC) ile yuzustu kopru (r=0,395, p=0,002), fleksor endurans (r=0,256, p=0,049) ve Sorensen testleri (r=0,255 p=0,049) arasinda pozitif yonde anlamli iliski tespit edildi. Birinci saniyedeki zorlu ekspiratuar volum (%FEV1) ile yuz ustu kopru (r=0,408, p=0,001), fleksor endurans (r=0,358, p=0,005) ve yan kopru testleri (r=0,277, p=0,032) arasinda pozitif anlamli korelasyon bulundu. MIP ile yuz ustu kopru (r=0,376, p=0,003) yan kopru testleri (r=0,470, p<0,001) arasinda pozitif iliski saptandi. MEP ile yuzustu kopru (r=0,401, p=0,002) ve yan kopru (r=0,365, p=0,004) testleri arasinda pozitif yonde anlamli korelasyon oldugu bulundu. Tartisma: Solunum fonksiyonlari ve solunum kas kuvveti ile govde stabilizasyonu saglayan kaslarin enduransi iliskilidir. Govde kas enduransi egzersizlerinin solunum fonksiyonlarina pozitif yonde etki edebilecegi soylenebilir.
Intraday information diffusion on nonsimultaneous trading

This dissertation presents an in-depth investigation of the S&P 500 pre-market futures predictive power on its underlying index. At the outset, this research develops an information diffusion model of market-to-firm information flow on an intraday futures and index trading framework. This model incorporates fundamental and myopic traders with irrational expectations and generates momentum and reversal in return covariance. The market equilibrium leads to a theoretical proposition that the overnight returns on the futures market will predict next day spot index movements. The analysis theoretically implies that the information spillover strengthens at the spot opening, and the level of market uncertainty is negatively correlated with the strength of price linkage. The subsequent chapter empirically tests this proposition utilizing a modified vector autoregressive model with thirty-five intraday S&P 500 returns. The results evidently validate that the S&P 500 pre-market futures returns are positively correlated to the index returns on the spot opening as well as across the entire regular trading session. Additionally, the spillover size increases as the futures corresponding return intervals become narrower and closer to the spot opening. This research introduces several signal trading strategies to demonstrate the usefulness of the pre-market futures predictive power. The backtesting locates several pre-market signals that outperform the index benchmark. Consistent with the aforementioned discoveries, the drawdown analysis finds that the magnitude of information spillover is more pronounced when market volatility is low. The information advantage of the pre-market futures market is validated for these strategies.