Miracle-dz/UniFAR-FTUs huggingface dataset:
How to Analyze Cancer Progression in COVID-19 Pandemic?

Background: The constant news about the coronavirus is scary. It is not possible to separate treatment for Cancer due to COVID-19. An effective treatment comparison strategy is needed. We need to have a handy tool to understand cancer progression in this unprecedented scenario. Linking different events of cancer progression is the need of the hour. It is a methodological challenge.Methods: This article is dedicated to explore the time lag effect and make statistical inference about the best experimental arm using Accelerated failure time model and regression methods. The work is presented as the occurrence of other events as a hazard rate after the first event (relapse). The time lag effect between the events is linked and analyzed. Results: The results are further analyzed and presented to show the efficacy of our study. An accelerated failure time model is also applied with the transition states and the dependency structure between the gap times are explained using auto-regression. The effects of Arms are compared using the coefficient of auto-regression and accelerated failure time (AFT) models.Conclusions: We provide the solutions to overcome the issue with interval between two consecutive events in motivating head and neck cancer (HNC) data. COVID-19 is not going to leave us soon. We have to carry several cancer clinical trials in presences of COVID-19. We presented a comprehensive analytical strategy to analyze cancer clinical trial data during this pandemic.Keywords: COVID-19, Accelerated Failure Time, Proportional Hazard Model, Bayesian, Auto-Regression.
Controlled Gait Planning of Humanoid Robot NAO Based on 3D-LIPM Model

Gait planning is essential for biped robots because the stability of the two support is very challenging task. A special attention is required to get a stabilized gait for humanoid robots. In this paper, 3D-LIPM (linear inverted pendulum model) is used to solve the gait planning problems of humanoid robots. Humanoid robot NAO is utilized as robotic platform. The structure of the robotic platform decides the period step height and step length. The gait planning consists of model of 3D-LIPM and ZMP (zero moment point). Simulation and experiments are carried out on simulated and real NAO, and showing good agreement with each other. An ideal controlled gait is obtained using the proposed technique.
Germination of tucumã (Astrocaryum aculeatum G. Mey.) as a function of thermal pretreatment and stratification temperature

Abstract: Germination of tucumã (Astrocaryum aculeatum G. Mey.) seeds is slow and although the removal of the endocarp favors the speed of the process, the time is still considered long. Thus, this study aimed to investigate the effects of different pretreatment and stratification temperatures on the germination of tucumã seeds. Two experiments were set up. The first experiment was conducted using a completely randomized design in a factorial scheme and seedling emergence was evaluated as a function of the pretreatment of diaspores at different temperatures (27, 30, 35, and 40 °C) during different periods (20, 40, and 60 days). The second experiment was also conducted in a completely randomized design and seed germination was evaluated as a function of seed stratification at constant (25, 30, 35, and 40 °C) and alternating temperatures (26 - 30, 26 - 35, and 26 - 40 °C). Germination decreased progressively in all tested periods as the pretreatment temperature increased. Seed stratification at different constant and alternating temperatures showed different results. The pretreatment of diaspores at different temperatures for different periods was not effective in overcoming the dormancy of tucumã seeds. Seed stratification at alternating temperatures, with the highest thermal amplitude (26 - 40 °C), favored the overcoming of dormancy and the germination of tucumã seeds.
The Effect of Al2O3 or SiO2 Addition on the Thermal Shock Resistance of Y2O3-Stabilized ZrO2

Y2O3含有量を4-17wt%と変化させた安定化ZrO2の耐熱衝撃性について検討した. 円板試料を1100℃に急熱後, 室温まで約500℃/minで急冷するサイクルを繰り返して熱衝撃試験を行った. ZrO2-4wt% Y2O3は単斜晶ZrO2の割合が多いため, 単斜晶→←正方晶のマルテンサイト変態に伴う寸法変化が著しく, 耐熱衝撃性が劣る. 一方, 立方晶単相のZrO2-12及び17wt% Y2O3では相変態は見られないが, 破壊靱性値が低いためにやはり耐熱衝撃性は劣る. ZrO2-7wt% Y2O3では, 変態に伴う寸法変化が比較的小さく, また破壊靱性値も比較的高いために良好な耐熱衝撃性を示す. ZrO2-7wt% Y2O3に, 更に0. 5-4wt%のAl2O3を添加すると気孔率が低下し, 硬さ及び破壊靱性値が向上して耐熱衝撃性が改善される. また, ZrO2-7wt% Y2O3では, 単斜晶ZrO2粒同士が結合して大きな集合体となっているのに対して, Al2O3添加材では球状の単斜晶ZrO2粒が比較的孤立して存在している. 熱衝撃試験において, クラックは主に単斜晶ZrO2から発生すると考えられ, 単斜晶ZrO2の形態の違いも耐熱衝撃性改善の原因の一つと考えられる. なお, SiO2を添加しても耐熱衝撃性の改善は認められない.
Female Caregiver Devotion as a Stress Factor in Caring for Hospitalized Elderly in Indonesia

Objective: To explore the female caregiver stress factors during caring for hospitalized elderly with chronicillness at Universitas Sumatera Utara/USU Hospital, Medan.Method: This study was a qualitative research with phenomenological approach. The participants arecollected with purposive sampling method with inclusion criteria; a primary female caregiver for the elderlyfor more than one year, have a family relationship with the elderly, above 18 years old, suffer from moderateto heavy stress and willing to participate. Before data collection, the participants are identified for stresslevel with the Zarit Burden Inventory instrument which consists of 12 questions and 0 to 4 scale. The datacollection was conducted with an in-depth interview. The interview is verbatim transcribed and analyzedwith thematic analysis.Result: The result of this research involved nine female informal caregivers. Six caregivers are the theelderly’s daughter and three of them are the elderly’s wife. The age of the caregiver is varying, from 32 –67 years old. Seven caregivers are suffering from moderate stress and two of the participants assessed withheavy stress. The research themes emerge four main themes, namely (1) Financing elderly, (2) Caregiverfatigue, (3) Experiencing negative relationship, and (4) Female devotion in the family.Conclusion: Female devotion in a family is considered as a functional duty which impact the women inmany aspects, physically and mentally. This research showed that the filial piety impacts the female caregiverin a stress condition. Therefore, it is strongly advised to consider female caregiver in a holistic interventionalong with the elderly during hospitalization.
Antiulcerogenic Effect of Aqueous Seed and Rind Extracts of Citrullus lanatus (Water Melon) in Ethanol-Induced Gastric Ulcer Albino Rats -

The present study was undertaken to evaluate anti ulcer activity of aqueous seed and rind extracts of Citrullus lanatus (watermelon) in ethanol induced gastric ulcer model in albino rats. The experiment was divided in to two models ( A: animals pre-treated with aqueous seed extract of watermelon ; B: those per-treated with aqueous rind extract of watermelon ) in each, four groups of rats were pre-treated with distilled water (control), Ranitidine (300mg/kg) for each, 150 and 300mg/kg seed and rind extracts were given to pre-treated animals in both models. Rats pre-treated with seed and rind extracts showed significant (P˂0.05) dose-dependent decrease in gastric lesions formation. Ulcerogenesis was significantly (P˂0.05) reduced in pre-treated groups compared with control (P˂0.05). However, the per centage curative effect was effectively high in (seed 75% and rind 70%) and was also dose dependent. The result indicates that Citrullus lanatus (watermelon) seed and rind possess potential gastroprotective and antiulcerogenic activities in ethanol induced gastric ulceration. And is probably due to high citrulline and flavonoid contents which might influence both NO synthesis and antioxidant defence mechanism that cumulatively inhibit gastric acid secretion.
La loi Cornudet, un urbanisme hygiéniste et social

La loi Cornudet est votee le 14 mars 1919, a la suite de dix annees de gestation et de debats parlementaires. Cette loi oblige les villes francaises de 10 000 habitants et plus a se doter d’un Plan d’Amenagement, d’Embellissement et d’Extension (PAEE) integrant des servitudes hygienistes, archeologiques et esthetiques. La loi concerne tout a la fois les grandes communes du departement de la Seine et les communes en voie d’accroissement (dont la liste aura ete etablie par le Conseil general du departement), les stations balneaires, maritimes, hydrominerales, climatiques, sportives et autres (soumises a la taxe de sejour, dont la population augmente de 50 % ou plus a certaines epoques de l’annee, et dont la liste sera etablie par le Prefet), ainsi que les agglomerations presentant un caractere pittoresque, artistique et historique (inscrites sur une liste etablie par les commissions departementales des sites et monuments naturels). Le texte de loi est modifie et complete le 19 juillet 1924 afin de soumettre les operations de lotissements a un regime d’autorisation prealable. La loi Cornudet amorce un siecle de reglementation urbaine et architecturale, a l’instar de la loi Loucheur du 13 juillet 1928, qui etablira pour sa part un programme de construction d’habitation a bon marche et de logement en vue de remedier a la crise de l’habitation insalubre.
Complete mitochondrial genome sequence of the global invasive species Stictocephala bisonia (Hemiptera: Membracidae: Smiliinae)

Abstract Stictocephala bisonia Kopp et Yonke, 1977, an invasive alien species colonizing Taibai County, Shaanxi Province, China, belongs to the subfamily Smiliinae. The total mitogenome sequence size is 15,803 bp in length, consists of 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes and one control region, and shows a positive AT skew. Phylogenetic analysis results strongly support that treehoppers (Membracidae and Aetalionidae) are monophyletic, and indicate that Smiliinae could be proposed as a separate family.
Comparative transcriptome profiling of a resistant vs susceptible bread wheat (Triticum aestivum L.) cultivar in response to water deficit and cold stress

Bread wheat (Triticum aestivum L.) is one of the most important agricultural plants wearing abiotic stresses, such as water deficit and cold, that cause its productivity reduction. Since resistance to abiotic factors is a multigenic trait, therefore modern genome-wide approaches can help to involve various genetic material in breeding. One technique is full transcriptome analysis that reveals groups of stress response genes serving marker-assisted selection markers. Comparing transcriptome profiles of the same genetic material under several stresses is essential and makes the whole picture. Here, we addressed this by studying the transcriptomic response to water deficit and cold stress for two evolutionarily distant bread wheat varieties: stress-resistant cv. Saratovskaya 29 (S29) and stress-sensitive cv. Yanetzkis Probat (YP). For the first time, transcriptomes for these cultivars grown under abiotic stress conditions were obtained using Illumina based MACE technology. We identified groups of genes involved in response to cold and water deficiency stresses, including responses to each stress factor and both factors simultaneously that may be candidates for resistance genes. We discovered a core group of genes that have a similar pattern of stress-induced expression changes. The particular expression pattern was revealed not only for the studied varieties but also for the published transcriptomic data on cv. Jing 411 and cv. Fielder. Comparative transcriptome profiling of cv. S29 and cv. YP in response to water deficit and cold stress confirmed the hypothesis that stress-induced expression change is unequal within a homeologous gene group. As a rule, at least one changed significantly while the others had a relatively lower expression. Also, we found several SNPs distributed throughout the genomes of cv. S29 and cv. YP and distinguished the studied varieties from each other and the reference cv. Chinese Spring. Our results provide new data for genomics-assisted breeding of stress-tolerant wheat cultivars.
The Value of Lactate Dehydrogenase in Predicting Rhabdomyolysis-Induced Acute Renal Failure; a Narrative Review

Introduction: Determining the diagnostic value of available biomarkers in predicting rhabdomyolysis-induced acute kidney injury (AKI) is a priority. This study aimed to review the current evidence about the value of lactate dehydrogenase (LDH) in this regard. Methods: In this narrative review, the papers in PubMed, Embase, and web of science were studied. The keywords prognosis, prognoses, prognostic, LDH, rhabdomyolysis, emergency patients, and acute kidney failure or AKI had been selected from MeSH medical dictionary. Related papers written in English and published from November 2007 to December 2020 were selected. Results: Finally, 14 articles were accepted for analysis. Among the selected articles, four were randomized clinical trials, seven were cross-sectional, and three were case-control studies. The results of the present review showed that abuse of illegal drugs is the most common cause of rhabdomyolysis. AKI is the most serious complication of rhabdomyolysis reported in the studies. These studies have shown a three-fold increase in AKI following drug-induced rhabdomyolysis. The review of the included articles shows that high LDH can predicts AKI, especially in critical and emergency situations such as rhabdomyolysis where there is a risk of death if diagnosed late. These studies show that LDH increases in the presence of renal failure and tissue damage. Conclusion: Serum LDH is an appropriate and cost-effective prognostic indicator that can be used for risk classification of patients at risk for rhabdomyolysis-induced AKI.
Durnonovariaodus maiseyi gen. et sp. nov., a new hybodontiform shark-like chondrichthyan from the Upper Jurassic Kimmeridge Clay Formation of England

A partial skeleton of a hybodontiform shark-like chondrichthyan from the Upper Jurassic Kimmeridge Clay Formation of Dorset, England, is described and designated as a new genus and species, Durnonovariaodus maiseyi gen. et sp. nov. The holotype and only known specimen, which is represented by disarticulated splanchnocranial elements with associated teeth, a single dorsal fin spine, the pelvic girdle, as well as unidentifiable cartilage fragments, plus countless dermal denticles, exhibits a puzzling combination of dental and skeletal features, providing important new insights into the morphological and ecological diversity of hybodontiforms. Durnonovariaodus gen. nov. displays a unique set of dental characters, showing close morphological resemblance to Secarodus from the Middle Jurassic of England, which was erected for distinctive, strongly labio-lingually compressed multicuspid cutting teeth originally described as Hybodus polyprion. Skeletally, Durnonovariaodus gen. nov. resembles Hybodus and Egertonodus in having a palatoquadrate with a palatobasal process and an ethmoidal articular surface, combined with the possession of dorsal fin spines ornamented with costae. Therefore, and given the absence of any conclusive phylogenetic framework, Durnonovariaodus maiseyi gen. et sp. nov. is here tentatively referred to Hybodontidae until more complete material becomes available in order to enable a more reliable suprageneric identification. The holotype of Durnonovariaodus maiseyi gen. et sp. nov. contains two separate pelvic half-girdles, a feature previously considered as evolutionarily primitive among hybodontiforms. However, unfused pelvic half-girdles also occur in the supposedly closely related species Hybodus hauffianus and may in fact have been more widely distributed among hybodontiforms than previously thought, thus rendering the phylogenetic utility of separated pelvic half-girdles for inferring hybodontiform interrelationships difficult and unresolved.
Protocols Used by Occupational Therapists on Shoulder Pain after Stroke: Systematic Review and Meta-Analysis

Introduction Shoulder pain as a consequence after a stroke has multifactorial causes and can prevent the functional return of the upper limb. In addition, the effectiveness of clinical protocols applied by occupational therapists remains uncertain. Objective To identify the main treatments currently used by occupational therapists for pain in the shoulder after a stroke. Method Articles in English published between 2015 and 2019, of the randomized clinical trial type, with populations that stroke survivors a stroke and sequelae of shoulder pain were selected. The terms and combinations used were “shoulder pain and stroke and occupational therapy,” in the electronic databases, Directory of Open Access Journals (DOAJ), Occupational Therapy Systematic Evaluation of Evidence (OTseeker), and PubMed. Statistical Review Manager (version 5.3) established the significance level P ≤ 0.05. Results Thirty-nine articles were found, but only four met the inclusion criteria. Electrical stimulation, therapeutic bandaging, and dry needling were eventually employed. For the meta-analysis, pain was the primary outcome, and range of motion (ROM) and upper limb function were secondary. Pain, ROM (external rotation, abduction, and flexion), and manual function were compared, and the meta-analysis showed improvement in the treatment group in clinical trials: pain (MD -2.08; 95% CI -3.23, -0.93; P = 0.0004), ROM (MD 4.67; 95% CI 1.54, 7.79; P = 0.0003), and manual function (MD 1.84; 95% CI 0.52, 3.16; P = 0.006). Conclusion Dry needling, California tripull taping (CTPT), and functional electrical stimulation controlled by brain-machine interface (BCI-FES) are proved effective in shoulder pain and functionality.
Environmental hotspots for antibiotic resistance genes

Bacterial resistance toward broad‐spectrum antibiotics has become a major concern in recent years. The threat posed by the infectious bacteria and the pace with which resistance determinants are transmitted needs to be deciphered. Soil and water contain unique and diverse microbial communities as well as pools of naturally occurring antibiotics resistant genes. Overuse of antibiotics along with poor sanitary practices expose these indigenous microbial communities to antibiotic resistance genes from other bacteria and accelerate the process of acquisition and dissemination. Clinical settings, where most antibiotics are prescribed, are hypothesized to serve as a major hotspot. The predisposition of the surrounding environments to a pool of antibiotic‐resistant bacteria facilitates rapid antibiotic resistance among the indigenous microbiota in the soil, water, and clinical environments via horizontal gene transfer. This provides favorable conditions for the development of more multidrug‐resistant pathogens. Limitations in detecting gene transfer mechanisms have likely left us underestimating the role played by the surrounding environmental hotspots in the emergence of multidrug‐resistant bacteria. This review aims to identify the major drivers responsible for the spread of antibiotic resistance and hotspots responsible for the acquisition of antibiotic resistance genes.
A Western‐style dietary pattern is associated with cerebrospinal fluid biomarker levels for preclinical Alzheimer's disease—A population‐based cross‐sectional study among 70‐year‐olds

Diet may be a modifiable factor for reducing the risk of Alzheimer's disease (AD). Western‐style dietary patterns are considered to increase the risk, whereas Mediterranean‐style dietary patterns are considered to reduce the risk. An association between diet and AD‐related biomarkers have been suggested, but studies are limited.
Controlled growth of well-aligned ZnO nanowire arrays using the improved hydrothermal method

Well-aligned ZnO nanowires were hydrothermally synthesized based on a facile method for preparing the ZnO seed layer which was derived from the combination of a sol—gel process and the spin-coating technique. The effect of the contents of growth solution and the growth duration on the morphology of ZnO nanowires has been investigated. The results indicated that long and vertically aligned ZnO nanowires could be obtained by adjusting the contents of ammonia and polyethyleneimine (PEI) in the growth solution. Under the optimized condition, the length of ZnO nanowires increased fast and almost linearly with the growth duration. After 10 h incubation, ZnO nanowires more than 25 μm in length were obtained. By combining the conventional photolithographic method with this hydrothermal approach, long and well-aligned ZnO nanowire arrays were selectively grown on the substrate. In addition, the bottom fusion at the foot of the nanowires has been obviously improved. The results demonstrated that the improved hydrothermal process is favorable to synthesize long and well-aligned ZnO nanowires, and possesses good process compatibility with the conventional photolithographic technique for preparing ZnO nanowire arrays. So it has great potential in applications such as display and field emission devices.
Undifferentiated Thyroid Carcinoma With Anaplastic Features in a 78-Year-Old Filipino Female: A Case Report

Abstract Background: Anaplastic thyroid carcinoma (ATC) accounts for 0.8-9.8% of all thyroid cancers globally with a median survival from diagnosis of 5 months. Clinical Case: A 78-year-old Filipino female sought consult due to a rapidly progressive anterior neck mass. This started as a centimeter-sized nodule initially noted three months prior. Two months after, there was gradual enlargement to a fist-size, movable mass, hard in consistency associated with dysphagia and hoarseness of voice. On consult, neck ultrasound revealed an enlarged right thyroid with a mass in the right lobe (TI-RADS 5), multinodular with no lymphadenopathy. Furthermore, a CT scan of the neck was done to evaluate for other structural causes of dysphagia showing no intrathoracic extension. Patient was advised surgery but was lost to follow up due to lockdown from COVID-19. In the interim, patient was admitted for aspiration pneumonia. IV antibiotics were initiated and urgent surgery was advised to relieve patient of respiratory compromise. Patient was airlifted to a tertiary care center for further management. Baseline thyroid function tests were normal. Repeat neck imaging showed interval increase in the hypodense mass measuring 6x9x8 cm (from 3x4x5 cm) (APxWxCC) extending to the hypopharynx and laryngeal vestibule with mass effect to the trachea and esophagus. A multidisciplinary meeting was done to establish goals of care. On the 3rd hospital day, a tracheostomy with incisional biopsy and frozen section was done which revealed round to spindle cell neoplasm with anaplastic features. No further surgical resection was done and specimen was sent for immunohistochemical staining. Long term enteral access was secured during the same operation. Final histopathology showed undifferentiated thyroid carcinoma with anaplastic features and no definite lymphovascular invasion. Immunohistochemical markers were negative for CD3, CD20, Thyroglobulin, TTF-1, PAX8, Calcitonin and Pancytokeratin which reveal loss of tumor antigenicity, consistent with the histopathologic diagnosis. Metastatic work-up revealed varisized pulmonary, subpleural and hepatic nodules with lymphangitic carcinomatosis. Patient was staged as IVC (T4N1M1). Patient was referred for radiation to maximize local control, to complete 33 fractions of 200 cGy on the thyroid mass and received one cycle of Paclitaxel before discharge. Concurrent chemoradiation was continued and completed 29 cycles of radiation and 2 cycles of Paclitaxel which significantly reduced the tumor size. However, the patient succumbed to acute coronary syndrome on her third admission. Conclusion: There is currently no consensus first-line treatment modality available worldwide. Although the diagnosis and treatment of ATC is considered medically urgent, end-of-life planning must be given high priority in order to optimize the quality of the patient’s remaining life.