Miracle-dz/UniFAR-FTUs huggingface dataset:
Riproximin Exhibits Diversity in Sugar Binding, and Modulates some Metastasis-Related Proteins with Lectin like Properties in Pancreatic Ductal Adenocarcinoma

Riproximin (Rpx) is a type II ribosome-inactivating protein with specific anti-proliferative activity. It was purified from Ximenia americana by affinity chromatography using a resin coupled with lactosyl residues. The same technique facilitated isolation of proteins with lectin-like properties from human Suit2-007 and rat ASML pancreatic cancer cells, which were termed lactosyl-sepharose binding proteins (LSBPs). The role of these proteins in cancer progression was investigated at mRNA level using chip array data of Suit2-007 and ASML cells re-isolated from nude rats. These data compared significant mRNA expression changes when relating primary (pancreas) and metastatic (liver) sites following orthotopic and intraportal implantation of Pancreatic Ductal Adenocarcinoma (PDAC) cells, respectively. The affinity of Rpx to 13 simple sugar structures was modeled by docking experiments, the ranking of which was principally confirmed by NMR-spectroscopy. In addition, Rpx and LSBPs were evaluated for anti-proliferative activity and their cellular uptake was assessed by fluorescence microscopy. From 13 monosaccharides evaluated, open-chain rhamnose, β-d-galactose, and α-l-galactopyranose showed the highest affinities for site 1 of Rpx’s B-chain. NMR evaluation yielded a similar ranking, as galactose was among the best binders. Both, Rpx and LSBPs reduced cell proliferation in vitro, but their anti-proliferative effects were decreased by 15–20% in the presence of galactose. The program “Ingenuity Pathway Analysis” identified 2,415 genes showing significantly modulated mRNA expression following exposure of Suit2-007 cells to Rpx in vitro. These genes were then matched to those 1,639 genes, which were significantly modulated in the rat model when comparing primary and metastatic growth of Suit2-007 cells. In this overlap analysis, LSBP genes were considered separately. The potential suitability of Rpx for treating metastatic Suit2-007 PDAC cells was reflected by those genes, which were modulated by Rpx in a way opposite to that observed in cancer progression. Remarkably, these were 14% of all genes modulated during cancer progression, but 71% of the respective LSBP gene subgroup. Based on these findings, we predict that Rpx has the potential to treat PDAC metastasis by modulating genes involved in metastatic progression, especially by targeting LSBPs.
Biomechanical Comparison of the Reverse Hyperextension Machine and the Hyperextension Exercise.

Lawrence, MA, Chin, A, and Swanson, BT. Biomechanical comparison of the reverse hyperextension machine and the hyperextension exercise. J Strength Cond Res XX(X): 000-000, 2019-The purpose of this study was to compare activation of the erector spinae, gluteus maximus, and biceps femoris muscles, lower back extension moment, and lower extremity range of motion (ROM) between the reverse hyperextension (RHE) and hyperextension (HE) exercises. Motion and muscle activation of the trunk and lower extremity were measured while 20 recreationally active individuals performed 2 sets of 10 repetitions of each exercise. Equivalent loads were used for each exercise. Peak, average, and integrated muscle activity, low back moment, and ROM between the trunk and pelvis and the thigh and trunk were calculated. A Wilcoxon signed-rank test (p = 0.05) revealed significantly greater integrated activity of the biceps femoris and gluteus maximus during the HE exercise. The RHE exercise generated greater peak (+129%), integrated (+63%), and mean (+78%) low back moment as compared to the HE exercise. The RHE resulted in a significantly greater thigh to trunk ROM, 76.6 compared with 64.7. However, the RHE used less lumbar flexion, 20.4 compared with 31.1 for the HE. The RHE movement profile is preferable because it provides greater hip ROM with less angular stress and equivalent erector spinae activity.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
Computational Linguistics Metrics for the Evaluation of Two-Part Counterpoint Generated with Neural Machine Translation

In this paper, two-part music counterpoint is modelled as a neural machine translation (NMT) task, and the relevance of automatic metrics to human-targeted evaluation is investigated. To this end, we propose a novel metric and conduct a user study comparing it to the automatic scores of a base model known to perform well on language tasks along with different models obtained with hyper-parameter tuning. Insights of this investigation are then speculatively extended to the evaluation of generative music systems in general, which still lacks a standardised procedure and consensus.
Did You “Read” the Next Episode? Using Textual Cues for Predicting Podcast Popularity

Podcasts are an easily accessible medium of entertainment and information, often covering content from a variety of domains. However, only a few of them garner enough attention to be deemed ‘popular’. In this work, we investigate the textual cues that assist in differing popular podcasts from unpopular ones. Despite having very similar polarity and subjectivity, the lexical cues contained in the pod-casts are signiﬁcantly different. Thus, we employ a triplet-based training method, to learn a text-based representation of a podcast, which is then used for a downstream task of “popu-larity prediction”. Our best model received an F1 score of 0.82, achieving a relative improvement over the best baseline by 12.3%.
Future Directions and Considerations for Talent Identification in Australian Football

As the focus on the elite Australian Football League competition becomes greater so too does the demand for success. Clubs are heavily scrutinized for their draft selections and as such are taking more interest in the younger levels of competition in an attempt to identify and monitor talent. Based on contemporary talent identification knowledge, this review examines the current talent identification process in Australian football, with a focus on areas to potentially improve or inform future developments. Currently, a significant gap exists between static and isolated assessment procedures used to identify talent in Australian football and the dynamic nature of match play. Future assessments should consider factors such as maturation, fatigue and ecological dynamics. The addition of a valid and reliable technical skill assessment (e.g., a small-sided game) to the current Australian Football League draft combine was recommended.
The Neolithic Demographic Transition in the Central Balkans: population dynamics reconstruction based on new radiocarbon evidence

In this paper, we test the hypothesis of the Neolithic Demographic Transition in the Central Balkan Early Neolithic (6250–5300 BC) by applying the method of summed calibrated probability distributions to the set of more than 200 new radiocarbon dates from Serbia. The results suggest that there was an increase in population size after the first farmers arrived to the study area around 6250 BC. This increase lasted for approximately 250 years and was followed by a decrease in the population size proxy after 6000 BC, reaching its minimum around 5800 BC. This was followed by another episode of growth until 5600 BC when population size proxy rapidly declined, reaching the minimum again around 5500 BC. The reconstructed intrinsic growth rate value indicates that the first episode of growth might have been fuelled both by high fertility and migrations, potentially related to the effects of the 8.2 ky event. The second episode of population growth after 5800 BC was probably owing to the high fertility alone. It remains unclear what caused the episodes of population decrease. This article is part of the theme issue ‘Cross-disciplinary approaches to prehistoric demography'.
DeepFunc: A Deep Learning Framework for Accurate Prediction of Protein Functions from Protein Sequences and Interactions

Annotation of protein functions plays an important role in understanding life at the molecular level. High‐throughput sequencing produces massive numbers of raw proteins sequences and only about 1% of them have been manually annotated with functions. Experimental annotations of functions are expensive, time‐consuming and do not keep up with the rapid growth of the sequence numbers. This motivates the development of computational approaches that predict protein functions. A novel deep learning framework, DeepFunc, is proposed which accurately predicts protein functions from protein sequence‐ and network‐derived information. More precisely, DeepFunc uses a long and sparse binary vector to encode information concerning domains, families, and motifs collected from the InterPro tool that is associated with the input protein sequence. This vector is processed with two neural layers to obtain a low‐dimensional vector which is combined with topological information extracted from protein–protein interactions (PPIs) and functional linkages. The combined information is processed by a deep neural network that predicts protein functions. DeepFunc is empirically and comparatively tested on a benchmark testing dataset and the Critical Assessment of protein Function Annotation algorithms (CAFA) 3 dataset. The experimental results demonstrate that DeepFunc outperforms current methods on the testing dataset and that it secures the highest Fmax = 0.54 and AUC = 0.94 on the CAFA3 dataset.
Back to Normal Symmetry? Biomechanical Variables Remain More Asymmetrical Than Normal During Jump and Change-of-Direction Testing 9 Months After Anterior Cruciate Ligament Reconstruction

Background: After anterior cruciate ligament reconstruction (ACLR), athletes have demonstrated performance asymmetries as compared with healthy cohorts, but little research has investigated if biomechanical asymmetries are also different during jump and change-of-direction (CoD) tasks between groups. Purpose: To identify if differences in magnitude of asymmetry of biomechanical and performance variables exist between these groups. Study Design: Controlled laboratory study. Methods: Analysis was conducted between 156 male patients 9 months after surgery and 62 healthy participants. Three-dimensional motion capture and analysis were carried out on a double-legged drop jump, a single-legged drop jump, a single-legged hop for distance, and planned and unplanned CoD. Asymmetry between limbs was calculated for each variable with root mean square difference between limbs. Statistical parametric mapping was used to identify the between-group differences in magnitude of asymmetry of performance and biomechanical variables. Results: There were differences in asymmetry of biomechanical variables across all jump and CoD tests, with greater asymmetries in the ACLR group. The majority of differences between groups were in the sagittal and frontal planes, with more differences found in the jump than CoD tests. The single-legged drop jump demonstrated large differences in performance asymmetry (effect size, 0.94) with small differences for both CoD tests (0.4) and none for the single-legged hop for distance. Conclusion: This study demonstrated greater asymmetry of biomechanical variables 9 months after ACLR as compared with healthy participants across all tests, suggesting insufficient rehabilitation. Clinical Relevance: This study highlights the importance of including biomechanical as well as performance variables when assessing rehabilitation status after ACLR. Registration: NCT02771548 (ClinicalTrials.gov identifier).
Dietary choline supplementation regulated lipid profiles of egg yolk, blood, and liver and improved hepatic redox status in laying hens.

Five hundred and forty 19-wk-old HyLine Brown laying hens were randomly distributed to 6 dietary treatments and fed 1of 6 corn-soybean meal-based diets added into choline with 0, 425, 850, 1,700, 3,400, and 6,800 mg/kg to investigate effects of dietary choline supplementation on lipid profiles of egg yolk, serum and liver, and hepatic redox status of laying hens. Yolk weight and total lipid, triglyceride, cholesterol and phosphatidylcholine, serum triglyceride, cholesterol, apolipoprotein B 100 (apoB 100), and very low density lipoprotein (VLDL), and liver relative weight, total lipid, triglyceride and apoB 100 as well as hepatic total superoxide dismutase and glutathione peroxidase (GSH-Px) activities, total antioxidant capacity (T-AOC), and malondialdehyde (MDA) in laying hens at weeks 58 and 68 of age were determined. The differences (P < 0.001) were caused by choline treatments in yolk phosphatidylcholine (at 850 mg/kg or more choline), serum VLDL, and liver triglyceride (at 1,700 and 3,400 mg/kg choline) of birds, at weeks 58 and 68 of age, and yolk total lipids were elevated (P < 0.05) by supplemental choline at 3,400 mg/kg whereas liver total lipids were reduced (P < 0.05) by 1,700 and 3,400 mg/kg choline addition. Hens fed diets supplemented choline had higher (P = 0.005) liver GSH-Px activity (with 3,400 mg/kg choline) and greater (P = 0.014) T-AOC (with 1,700 mg/kg choline) than those fed diets with 0 and 425 mg/kg choline addition. Choline affected serum VLDL, liver total lipid, triglyceride and apoB 100 at weeks 58 and 68 of age and hepatic GSH-Px activity, T-AOC and MDA at week 68 of age quadratically (P < 0.05), whereas it influenced total lipid and phosphatidylcholine of egg yolk linearly (P < 0.05) and quadratically (P < 0.05). In conclusion, dietary choline supplementation elevated yolk total lipid and phosphatidylcholine and serum VLDL, reduced liver total lipid and triglyceride, and enhanced hepatic GSH-Px activity and T-AOC in laying hens.
Physicians’ opinions about the causes of underreporting of occupational diseases

Abstract Occupational diseases cause an important burden on health and economy; however, they are substantially underestimated. We aimed to investigate the opinions of physicians about causes of underreporting of occupational diseases. We collected data with a questionnaire, listing 30 possible causes for underreporting of occupational diseases. 478 physicians participated in the study. The first 3 most frequent causes perceived as “very important” are; employers’ perception of occupational safety and health services as a loss of revenue (64.9%), prevalent employment without a legal contract (64.6%), and prevalent employment as subcontracted (59.4%). 52.1% of the physicians worked or currently working as an occupational physician. With the increase of working year as an occupational physician, there was a statistically significant decrease in the strength of importance for 17 of the 30 statements. This finding may be one of the important causes of underreporting of occupational diseases.
Lifetime vibration dose correlates with severity of the neurological component of hand-arm vibration syndrome among tyre shop workers in Kelantan, Malaysia

Introduction. Cumulative lifetime exposure to vibration is believed to contribute to more severe complications of hand-arm vibration syndrome (HAVS). Objectives. To determine prevalence of the neurological component of HAVS and the correlation between lifetime vibration dose (LVD) and neurological severity of HAVS among tyre shop workers in Kelantan. Methods. The cross-sectional study involved 200 tyre shop workers from two districts in Kelantan. Part one data were collected in the field using a questionnaire and hand-arm vibration was measured. Part two involved a set of hand clinical examinations (Purdue pegboard, Semmes-Weinstein monofilament and two-point discrimination tests) carried out for neurological component severity staging. LVD for each worker was calculated from data gathered in part one. For workers who had neurological symptoms, staging according to Stockholm workshop scales was done according to part two data. The strength of correlation between LVD and neurological stages was then determined using Spearman correlation. Results. Prevalence of neurological component was 37%. Spearman correlation between LVD and the neurological stages showed a moderate positive correlation. Conclusion. Cumulative lifetime exposure to hand-transmitted vibration is likely to be related to neurological severity of HAVS and therefore must be considered when assessing workers’ exposure to hand-arm vibration.
A Stochastic Control Model of Investment and Consumption with Applications to Financial Economics

Abstract This study considers a stochastic control model in which an economic unit has productive capital and liabilities in the form of debt. The worth of capital changes over time through investment and random Brownian fluctuations in the unit price of capital. Income from production is also subject to the random Brownian fluctuations. The existence of the solutions to the associated Hamilton Jacobi Bellman equation for this model is established and the optimal policies are characterized. The optimal advertising rate as a function of the market share, the optimal consumption rate and the fraction of the wealth invested in stock at any time are obtained. The worth of the capital and the optimal consumption policy are derived for the stochastic optimal investment consumption model associated with the Hamilton Jacobi Bellman equation. Analysis and numerical simulations are then presented.
Zao Ren An Shen capsule for chronic insomnia

Background: Zao Ren An Shen (ZRAS), a Chinese Herbal Medicine product, has been proposed as an alternative to recommended treatments for chronic insomnia. There is a lack of strong evidence supporting this proposition. Aims: To assess the efficacy and safety of ZRAS capsule for chronic insomnia compared to placebo. Methods: A parallel-group, double-blind, randomized-controlled trial will be performed in Western Sydney University, Australia. After a 1-week placebo run-in, adults with chronic insomnia (n = 90) will be randomized in a 1:1 ratio to receive either ZRAS capsule or placebo for 4 weeks. Insomnia severity (Insomnia Severity Scale score), sleep parameters (measured with the Consensus Sleep Diary and actigraphy), fatigue levels (Fatigue Severity Scale score), psychological status (Depression Anxiety Stress Scale score), quality of life (Assessment of Quality of Life score), and adverse events will be assessed at baseline, mid-treatment, post-treatment and at a 1-month follow-up. Expected outcomes: We hypothesize that ZRAS capsule will improve insomnia severity, sleep parameters, fatigue levels, psychological status, and quality of life better than placebo at mid-treatment, post-treatment, and follow-up. We also hypothesize that the number of adverse events provoked by ZRAS capsule will be similar to placebo at these time-points. Trial registration: Australia New-Zealand Clinical Trial Registry (Registration number ACTRN12619000140156).
AMC backed circularly polarized dual band antenna for Wi-Fi and WLAN applications

Abstract In this article the design and implementation of dual band circularly polarized antenna which is backed with AMC is presented. The proposed antenna consists of a novel heart shaped concentric ringshaped patch attached to meander line. The dimension of the antenna without AMC is 0.24 λ0 × 0.140 λ0 × 0.012 λ0 × and with AMC 0.43 λ0 × 0.43 λ0 × 0.32 λ0 and designed on a commercial FR4 substrate. The antenna gets worked at dual band applications such as 2.4 GHz (wi-fi) operates from 2.3 GHz to 2.5 GHz and 5.2 GHz (WLAN) operates from 4.7 GHz to 5.9 GHz and also gets circular polarization from 2.3 GHz to 2.5 GHz (200 MHz) and 4.95 GHz to 5.40 GHz (450 MHz) is achieved. In this article the proposed model is investigated towards circular polarization, radiation patterns and current distributions by varying parametric analysis is carried to analyze overall performance of antenna with and without AMC.
Mathematical Modeling of Convective Heat and Mass Transfer of a Rotating Nano-Fluid Bounded by Stretching and Stationary Walls in a Vertical Conduit

Abstract The influence of thermal emission and unvarying magnetic field of convective heat and mass transfer of a rotating nano-liquid in an upright conduit constrained by a stretching and motionless wall is studied. The temperature, concentration profile, primary and secondary velocities have been computed through similarity transformation and fourth-order Runge-Kutta shooting technique. The objective of this article is to measure the impact of emission constraint, Brownian movement constraint and Eckert number, thermophoresis constraint, Prandtl number, space, and temperature-dependent heat source constraint on velocity. The results are presented in tables and graphs. Further, various constraint impacts on the skin friction coefficient, heat and mass transfer rates are also explored. This work is pertinent to biotechnological and engineering uses, like mass and heat transfer enhancement of microfluids and design of bioconjugates.
Einfluss des Urlaubswetters auf das Reklamationsverhalten von Ferienhausgästen

Zusammenfassung Reiseentscheidungen werden von klimatischen Bedingungen und Wetterverhältnissen in der Destination abhängig gemacht. Das Wetter im Urlaub hat einen großen Einfluss auf das Urlaubserlebnis. Dieser Artikel untersucht, ob schlechtes Wetter zu einer höheren Reklamations-rate bei Ferienhausgästen führt. Dafür wurde der Zusammenhang zwischen dem Beschwerde-verhalten und den Wetterelementen Temperatur, Niederschlag, Windgeschwindigkeit und Luftfeuchtigkeit untersucht. Ein Zusammenhang konnte jedoch nicht angewiesen werden.
Wirkungen von Formatvariationen bei Erklärungen zum Schutz personenbezogener Daten auf betroffene Personen — Welche Lehren lassen sich aus empirischen Studien ziehen?

Gemäß Art. 5 Abs. 1 lit. a, Art. 7 Abs. 1 und Art. 12 Abs. 1 der Datenschutz-Grundverordnung (DSGVO) sind betroffene Personen über die Verarbeitung ihrer Daten allgemein sowie im Vorfeld zweckbezogen erteilter Verarbeitungseinwilligungen im Besonderen in präziser, verständlicher Form sowie einer klaren und einfachen Sprache umfassend zu informieren. Im InternetGeschäftsverkehr stellen Unternehmen solche Angaben über Datenschutzerklärungen (DSE) auf ihren Webseiten zur Verfügung. Betroffene lesen DSE selten und verstehen sie kaum. Dieses Defizit versucht man durch Verbesserungen der Darstellungsweisen von DSE zu reduzieren, die in etlichen wissenschaftlichen Untersuchungen vergleichend analysiert wurden. Dieser Beitrag gibt eine Synopse der einschlägigen empirischen Forschung zu Wirkungen von DSE-Formatvariationen auf datenschutzbezogene Verhaltensaspekte Betroffener. Insgesamt sprechen die Befunde aus 19 empirischen Studien dafür, dass sich allein durch Einsatz eines bestimmten DSE-Formats (z.B. vom Bundesjustizministerium empfohlener „One-Pager“) die DSE-Lesewahrscheinlichkeit, das DSE-Verständnis sowie DSE-Bewertungen Betroffener nicht signifikant gegenüber alternativen Präsentationsvarianten positiv beeinflussen lassen. Um Verhaltensveränderungen bei Betroffenen zu bewirken, sollten deshalb zusätzlich vor allem Softwarelösungen zur DSE-Qualitätsanalyse und zur Unterstützung zweckbezogener Einwilligungsentscheidungen zu Verarbeitungsvorgängen vorangetrieben werden.