Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Dundee Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are a common cause of adverse drug events (ADEs), but renal risks of NSAIDs are less well quantified than gastrointestinal and cardiac risks. This paper reports a systematic review of published population-based observational studies examining the risk of acute kidney injury (AKI) associated with NSAIDs in community-dwelling adults and those with pre-existing chronic kidney disease (CKD). Methods: MEDLINE and EMBASE databases were searched until June 2016, and 3789 papers screened. Ten studies reporting NSAID risk of AKI in the general population were included in random effects meta-analysis, of which five additionally reported NSAID risk in people with CKD. Results: In the general population, the pooled odds ratio (OR) of AKI for current NSAID exposure was 1.73 (95%CI 1.44 to 2.07), with somewhat higher risk observed in older people (OR 2.51, 95%CI 1.52 to 2.68). In people with CKD, individual study OR of AKI due to current NSAID exposure ranged from 1.12 to 5.25, with pooled estimate OR 1.63 (95% CI 1.22 to 2.19). Conclusions: No study reported baseline risk of AKI in different populations meaning absolute risks could not be estimated, but baseline risk and therefore the absolute risk of NSAID exposure is likely to be higher in people with CKD and older people. Large population based studies measuring AKI using current definitions and estimating the absolute risk of harm are needed in order to better inform clinical decision making.
UNIVERSIDADE FEDERAL DO PARANÁ GUSTAVO LUNARDON QUILLÓ AN ALGORITHM FOR CARBONATED WATER INJECTION (CWI) IN CARBONATE RESERVOIRS CURITIBA

An algorithm for calculating the behavior of carbonated brine injection in calcite rocks aiming at carbon geological storage is presented. The approach is designed to customize computational fluid dynamics simulations to include dissolution chemistry by integrating a CO2 solubility model, speciation calculations, mineral dissolution reactions and the consequent change in reservoir properties over time. The equilibrium and dissolution reactions are calculated sequentially, where an adaptive control of the time step ensures the rate of dissolution is computed from the correct equilibrium condition. The chemical equilibrium condition is calculated via the stoichiometric approach, where a system of three algebraic equations is solved using NewtonRaphson supplied with numerical derivatives in the Jacobian Matrix The reservoir is represented as a pseudo-homogeneous medium where alterations in rock properties are computed via a formulation based on Kozeny-Carman. Finally, a stabilization algorithm based on the Bjerrum plot of H2CO3 provides numerical robustness for the speciation calculations. The results are obtained attempting the minimum computational effort, allowing the estimation of the time frame for the system to reach the equilibrium condition and changes in rock structure.
University of Groningen The Netherlands Arrhythmogenic Cardiomyopathy Registry

Background Clinical research on arrhythmogenic cardiomyopathy (ACM) is typically limited by small patient numbers, retrospective study designs, and inconsistent definitions. Aim To create a large national ACM patient cohort with a vast amount of uniformly collected high-quality data that is readily available for future research. Methods This is a multicentre, longitudinal, observational cohort study that includes (1) patients with a definite ACM diagnosis, (2) at-risk relatives of ACM patients, and (3) ACM-associated mutation carriers. At baseline and every follow-up visit, a medical history as well information regarding (non-)invasive tests is collected (e.g. electrocardiograms, Holter recordings, A.S.J.M. te Riele and J.P. van Tintelen contributed equally and are joint senior authors. Electronic supplementarymaterial The online version of this article (https://doi.org/10.1007/s12471-019-1270-1) contains supplementary material, which is available to
Combined spinal-epidural versus epidural analgesia during labor : fetal effects and delivery outcomes Analgesia espinal-epidural combinada versus epidural

Pain during labor may elicit different responses that can be detrimental both to the mother and the fetus. Among the different methods used to relieve pain during childbirth, neuraxial analgesia has proven to be the most effective. The epidural technique and the combined spinal-epidural are the most common techniques for administrating neuraxial analgesia. Several studies have analyzed the adverse reactions of these techniques, by comparing their effects on uteroplacental perfusion measured by uterine contractions, fetal heart rate and the need to perform an emergency cesarean delivery due to these alterations. Comparing the results in these studies, it was demonstrated that, even though patients that had received a combined spinal-epidural presented greater fetal heart rate alterations, this did not increase perinatal complications significantly. These alterations have shown to be transient and, if recognized and treated promptly, do not increase maternal or fetal morbidity and mortality.
Review of Markov Switching and Threshold Regression Model 2 . 1 Markov Switching Regression Model

This paper extends the threshold model to Markov Switching model in order to relax a linear function between dependent and independent variables. The model allows non-linear function using the idea of Threshold model. We conducted both simulation and real data studies to evaluate the performance of the proposed model and found that the model performs well in both simulation and application studies. The application study revealed the negative impact of unemployment rate on industry production index when the market stays in recession and depression period. Conversely, the positive impact of Unemployment rate to Industry Production index is empirically evident during expansion and boom period.
Transforming Requirements into MDA from User Stories to CIM

Over the last few years, Model Driven Architecture (MDA) has become a central goal in the research areas as well as agile methodology. On the other hand, in order to reduce ambiguity in requirements specifications, UML has become a main purpose. It represents the best modeling language for software systems. Several works have been carried out in order to transform either the natural language into UML models, or model (CIM) to model (PIM) transformation. In previous work, we have implemented an algorithm that takes UML model (PIM) as input and generate another UML model (PIT) as output, in Scrum process. In this paper, we propose a method for the automatic transformation of user stories into behavioral models (CIM), and the development of a new plugin that transforms requirements into a behavioral model.
Fibromyalgia versus recommended drugs : An economic analysis alongside a 6-month randomised controlled trial conducted in Spain ( EFFIGACT study )

Citation for published version (APA): Luciano, J. V. , D’Amico, F. , Feliu-Soler, A. , McCracken, L. M. , Aguado, J., Peñarrubia-María, M. T. , . GarcíaCampayo, J. (2017). Cost-utility of Group Acceptance and Commitment Therapy for Fibromyalgia versus recommended drugs: An economic analysis alongside a 6-month randomised controlled trial conducted in Spain (EFFIGACT study). JOURNAL OF PAIN. https://doi.org/10.1016/j.jpain. 2017.03. 001
Interactive comment on “ Microstructure and texture evolution in polycrystalline ice during hot torsion . Impact of intragranular strain and recrystallization processes ” by Baptiste Journaux

pretation of this observation is that there is a heterogenous distribution in the magnitude and orientation of stress near grain boundaries. In other words, the presence of grain boundaries may enhance deformation, which would lead to a grain-size sensitive rheological behaviour such as described by Goldsby and Kohlstedt (2001). A grainsize sensitive rheological behaviour may operate at the higher strain conditions where weakening (increasing strain rate with time) is observed. Although it is possible that the weakening is entirely due to the alignment of grains with favourable orientation to operate easy slip at larger shear strain (i.e. geometric softening).
University of Dundee The hVPS 34-SGK 3 pathway counteracts inhibition of the PI 3 K-Akt to maintain mTORC 1 and tumour growth

We explore mechanisms that enable cancer cells to tolerate PI3K or Akt inhibitors. Prolonged treatment of breast cancer cells with PI3K or Akt inhibitors leads to increased expression and activation of a kinase termed SGK3 that is related to Akt. Under these conditions, SGK3 is controlled by hVps34 that generates PtdIns(3)P, which binds to the PX domain of SGK3 promoting phosphorylation and activation by its upstream PDK1 activator. Furthermore, under conditions of prolonged PI3K/Akt pathway inhibition, SGK3 substitutes for Akt by phosphorylating TSC2 to activate mTORC1. We characterise 14h, a compound that inhibits both SGK3 activity and activation in vivo, and show that a combination of Akt and SGK inhibitors induced marked regression of BT-474 breast cancer cellderived tumours in a xenograft model. Finally, we present the kinome-wide analysis of mRNA expression dynamics induced by PI3K/Akt inhibition. Our findings highlight the importance of the hVps34-SGK3 pathway and suggest it represents a mechanism to counteract inhibition of PI3K/Akt signalling. The data support the potential of targeting both Akt and SGK as a cancer therapeutic.
The role of expenditure components in determinantion of import demand : Empirical evidence from Pakistan Pakistan

This study is aimed at in-depth empirical analysis of impact of final expenditure components on import demand in Pakistan. ARDL bound testing approach to cointegration is used to analyze the long run relationship of import demand, relative prices of imports and components of final expenditure like household consumption, investment, exports and government consumption expenditures. Empirical results show that there exists a long run relationship between import demand and the macro components of final expenditure and relative prices. Long run coefficients indicate that elasticity of import demand with respect to different macro components of final expenditure is different. The impact of the all expenditure components on import demand is positive and significant. The relative prices have negative but insignificant relationship with import demand in Pakistan. For the analysis of Short Run dynamics, Vector Error Correction Model (VECM) has been used. The results show that all expenditure components have positive and significant impact on import demand in Pakistan while the effect of relative prices is also statistically insignificant in short run.
GUIDE : Guiding Users in Distributed Environments for WLAN and Ad Hoc Networks

Whereas there is a lot of work related to finding the location of users in WLAN and ad hoc networks, guiding users in these networks remains an unexplored area of research. In this paper we introduce the concept of node-to-node guiding and present two methods that can be used to implement it. One method is based on distance estimation whereas the other relies on the computation of a gradient in the neighborhood of the moving node. We implemented all proposed guiding techniques thus creating GUIDE, which is a GPS-free and infrastructure-free node-to-node guiding system. From our results we observed that distance-based guidance is highly sensitive to distance estimation errors. On the other hand, the method based on a gradient computation proved to be more robust. In this paper we also discuss how GUIDE can be generalized to node-to-node guidance in multihop ad-hoc networks and directions for future research.
Monsanto and Forage Genetics International Petition ( 12-321-01 p ) for Determination of Non-regulated Status of Event KK 179 Alfalfa OECD Unique Identifier : MON-ØØ 1795 Plant Pest Risk Assessment

The U.S. Department of Agriculture (USDA) prohibits discrimination in all its programs and activities on the basis of race, color, national origin, sex, religion, age, disability, political beliefs, sexual orientation, or marital or family status. (Not all prohibited bases apply to all programs.) Persons with disabilities who require alternative means for communication of program information (Braille, large print, audiotape, etc.) should contact USDA’S TARGET Center at (202) 720–2600 (voice and TDD).
EQUITY MUTUAL FUND PERFORMANCE EVALUATION: EVIDENCE FROM SCANDINAVIA

4 INTRODUCTION . 5 1. LITERATURE REVIEW AND THEORETICAL FRAMEWORK . 7 1.1 Mutual Funds and the Efficient Market Hypothesis . 7 1.4 Modern Portfolio Theory and the CAPM . 11 1.5 Methods and Measures for Portfolio Evaluation . 14 1.5. 1 Multifactor CAPM-s . 20 1.6 Home Equity Bias . 22 1.7 Previous Empirical Research and Methodology . 23 2. DATA AND METHODOLOGY . 26 2.1 Mutual Fund Data . 26 2.2 Methodology . 29 2.3 Descriptive Statistics . 32 3. RESULTS . 36 3.1 Performance Measuring Tools and the CAPM . 36 3.2 Multi-Factor Models . 39 3.3 Discussion of Results . 42 CONCLUSION . 44 KOKKUVÕTE . 46 LIST OF REFERENCES . 48 APPENDICES . 53 Appendix 1. List of funds in the Nordic-focused equally weighted portfolio . 53 Appendix 2. List of funds in the Global-focused equally weighted portfolio . 55 Appendix 3. Model outputs . 58 Appendix 4. Robustness checks for the multi-factor models . 62
Kimia merupakan salah satu cabang sains yang penting karena mampu membuat siswa mengerti tentang fenomena-fenomena yang terjadi di sekitar mereka [1]. Namun, kimia juga merupakan ilmu yang bersifat konseptual sehingga dibutuhkan daya abstraksi yang tinggi untuk memahami konsep-konsep tersebut, mulai

This study aims to analyze the learning styles of the students are in control of chemical concepts. The research was conducted in the second semester of academic year 2012/2013 at SMAN 2 Tangerang.This study is a descriptive research to find a match between the learning styles of students with mastery of chemistry concepts. The method used in this research is descriptive quantitative non-parametric analysis. The data generated from the test phase of the feasibility stage of data collection instruments and research on learning styles of students in order to obtain the subject's research. Then students with learning styles that consistently tested mastery of chemistry concepts through the instruments based on CCI (Chemical Concept Inventory). The results showed that there were 13 learning style based mapping MBTI learning styles. The test results of chemical concepts test scores show that there is a correspondence between the learning style and concept mastery of chemical LOT HOT. Each learning style is not there a significant difference to the mastery of chemistry concepts.
Does Rivalry Influence Selective Reporting in Scientific Publications?

Does rivalry influence selective reporting in scientific publications? We define ? rivalry? as a subset of competition that captures the subjective relationships between two competitors. Using data on headto-head clinical trials for antidepressants, we find that the likelihood of selectively reporting drugs’ side effects in scientific articles is higher when the drugs investigated in the trial are rivals rather than nonrival opponents. We also find partial support for our arguments that this effect is strengthened when the scientific team includes a firm scientist, and weakened when the focal drug pre-empted the rival drug at market entry. Our study is novel in that it is the first study that explores the link between rivalry, product-market competition, and the content of scientific articles. By revealing conditions that are likely to trigger a ? dark side? in publication practices, our study provides counterintuitive insights at the interplay between competition and science: What seems to be a practice aimed at mitigating uncertainty, i.e., the release of scientific information in product-market competition, can under some conditions enhance behavioral uncertainty and result in increased risk taking for firms that undertake comparative research.
CALCULATION IN EARLY SOFTWARE RELIABILITY ENGINEERING

System scenarios derived from requirements specification play an important role in the early software reliability engineering. A great deal of research effort has been devoted to predict reliability of a system at early design stages. The existing approaches are unable to handle scalability and calculation of scenarios reliability for large systems. This paper proposes modeling of scenarios in a scalable way by using a scenario language that describes system scenarios in a compact and concise manner which can results in a reduced number of scenarios. Furthermore, it proposes a calculation strategy to achieve better traceability of scenarios, and avoid computational complexity. The scenarios are pragmatically modeled and translated to finite state machines, where each state machine represents the behaviour of component instance within the scenario. The probability of failure of each component exhibited in the scenario is calculated separately based on the finite state machines. Finally, the reliability of the whole scenario is calculated based on the components’ behaviour models and their failure information using modified mathematical formula. In this paper, an example related to a case study of an automated railcar system is used to verify and validate the proposed strategy for scalability of system modeling.
Effects of Quicklime on Flesh Fly ( Diptera : Sarcophagidae ) Colonization

Entomological evidence in the form of immature blowflies (Diptera: Calliphoridae) and flesh flies (Diptera: Sarcophagidae) are often used in forensic investigations to estimate the minimum postmortem interval (mPMI). This is done by using species-specific growth charts established under ideal conditions. Clandestine burials often do not fall within these ideal conditions, and insect colonization can be influenced by the presence of chemicals meant to enhance the rate of decay, such as quicklime. While quicklime in fact slows decomposition, the direct effect of the presence of quicklime on insect colonization is poorly represented in literature. Two lamb livers were used as analogues for human remains in a field experiment. They were left open to colonization both treated with quicklime and untreated, while being monitored for insect activity. The results suggest a significant increase in attraction to the quicklime-treated liver, 70.52%, implying that quicklime might have acted as an olfactory attractant rather than an olfactory deterrent to gravid Sarcophagidae females.
Polymorphic variants in the DLX 1 gene and the risk of non-syndromic cleft lip with or without cleft palate

Non-syndromic cleft lip with or without cleft palate (NSCL/P, OMIM %1195130) is one of the most common craniofacial abnormalities. The frequency of NSCL/P varies widely across different regions of the world and depends on racial and ethnic background, and socioeconomic status [1, 2]. The birth prevalence of this malformation in European-derived populations is about 1/1000 live births [3]. Orofacial clefts represents a signifi cant public health burden since their treatment requires long-term and multidisciplinary management strategies. In addition, patients with this developmental anomaly may have a higher incidence of psychological disorders and cancer [4, 5]. Zhu et al. have shown that also parents having children with orofacial clefts have an increased risk of developing lymphomas or leukemia [6]. ABSTRACT
The role of bariatric surgery and appetite-related hormones metabolism in obesity treatment: a literature review

Одними из самых частых хирургических вмешательств, выполняемых при лечении ожирения, являются лапароскопическая рукавная резекция желудка (ЛРРЖ), лапароскопическая пликация большой кривизны желудка (ЛПБКЖ), лапароскопическое шунтирование желудка по Ру (ЛШЖР). Наряду с эффективной потерей веса эти операции приводят к изменениям в продукции гормонов аппетита, которые играют важную роль в эндокринной регуляции энергетического обмена. UDC: 616-008.9:577.175. 73]-056.257-089
Making long-term cooperation decision based on bilateral inter-organizational trust : Evidence of Mongolian SMEs

This paper investigates inter-organizational bilateral trust is important phenomenon for long-term cooperation. In order to be stable or permanent the cooperation, inter-organizational trust should be reciprocal as well as similar concept of ‘Prisoner Dilemma game theory’. Also, we considered reasons of why transaction costs are higher in developing markets are related with inter-organizational lower level trust. The hypothesized model tested on a sample 411 firms with a Mongolian SMEs. In conclusion, a result of the study demonstrates whether partner firms’ trust with other partner would be higher, the firms willing to continue their cooperation for a longer time.
. , v . 34 , n . 2 , p . 584-588 , 2005 Evaluation of Poultry Litter on Sorghum Straw Intake and Dry Matter Disappearance by Dry Cows 1

An experiment was carried out to evaluate supplementation of sorghum straw (SS) with poultry litter (PL) in a single offering/day, and minerals and their effects on feed intake, sorghum straw dry matter disappearance (DMD) in nylon bags and rumen liquid ammonia N concentration. A 4x4 latin square design with 17-day periods and four rumen fistulated stalled cows was used to compare four treatments: (0) SS alone, (M) SS + mineral mixture offered ad libitum (P) SS + 1 kg/day of a concentrate w ith 83.5 % PL and (PM) SS + supplements used in M and P. The concentrate was offered in one meal and rumen N concentration increase d to just over 100 mg/L between 1 and 3 h after feeding, decreasing to less than 50 mg/L after 7 h, levels similar to those on tr eatments without PL. Dry matter disappearance at 72 h and feed intake increased by the addition of concentrate, but not by mineral supplementation. These results show that the effect of supplementation with PL was due mainly to degradable nitrogen and not by the minerals. A single offering/day is not enough to maintain recommended ammonia N concentrations during most of the day.
Parameter Optimization of Hybrid Electric Vehicle Based on Multi-condition Optimization Algorithm

Coordinating and optimizing the parameters of hybrid electric vehicle (HEV) powertrain and energy control strategies is the key to improving fuel economy. The HEV drive system parameters have a significant impact on the vehicle's power, fuel economy and emissions performance. For HEV, the reasonable matching of the drive system parameters will directly determine whether the HEV can meet the energy conservation and environmental protection requirements. After determining the design goals and design of the hybrid vehicle, it is necessary to determine the selection of each component and its parameters. In order to achieve the best fuel economy under the condition of satisfying the vehicle dynamic constraints. Hybrid electric vehicle (HEV) is the most feasible product which combines new technology with old technology. It has the advantages of both pure electric vehicle and traditional internal combustion engine vehicle. Based on the multi-condition optimization algorithm, this paper proposes an optimization strategy for the parameters of the power system calculated according to the theoretical knowledge of the vehicle.