Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute Management of Anticoagulation-Associated Intracerebral Hemorrhage

Abstract The incidence of anticoagulation-associated intracerebral hemorrhage (OAC-ICH) is increasing along with demographic changes and patients requiring oral anticoagulation for atrial fibrillation. OAC-ICH is one of the most detrimental sub-types of hemorrhagic stroke, characterized by larger hemorrhage volumes, more frequent intraventricular hemorrhage, increased and prolonged hematoma enlargement. The impact of these outcome predictors’ results in greater mortality rates and larger numbers of patients left in functionally dependent states after ICH. Yet, evidence on treatment options for these severely affected patients remains limited, resulting in weak recommendations by international and European guidelines. Minimization of hematoma enlargement constitutes the main focus of acute care, possibly achieved by blood pressure and reversal management. In all OAC-ICH patients irrespective of anticoagulation agent, immediate and aggressive blood pressure reductions as fast as possible targeting systolic blood pressure levels of 140 mmHg (at least within 4–6 h) seems reasonable. Specifically, in vitamin-K-associated ICH, blood pressure reductions have been shown to be associated with reduced rates of hematoma enlargement. Reversal management in OAC-ICH should be carried out as quickly as possible, though accounting for the different anticoagulation agents used. In vitamin-K-associated ICH, recent large-sized multicenter investigations contributed to refining reversal strategies. One German-wide cohort study including roughly 1 200 patients identified for the first time beneficial target values to guide reversal treatment. Anticoagulation reversal should achieve INR values of less than 1.3 or 1.2 at least within 4 h after admission. Agents to be used comprise prothrombin complex concentrates (PCC), which may achieve faster and more complete reversal. This combined approach (blood pressure management and INR-reversal) was associated with significant reductions of hematoma enlargement and lower in-hospital mortality rates. For dabigatran-related bleeding complications, most recently an antidote (Idarucizumab) has been approved, which has been prospectively investigated and showed rapid and almost complete reversal as well as sufficient hemostasis. Currently, bleeding under the influence of factor-Xa inhibitors poses great difficulties because no antidote is available and efficacy of commonly used antagonizing agents, i. e. , PCC or fresh-frozen plasma (FFP), has not been proven for clinical use. The main aim of the present review focuses on acute-care management of OAC-ICH and tries to depict treatment options based on the most current data. Moreover, current neurocritical-care therapies for ICH will be reviewed to identify relevant implications specific to OAC-ICH treatment.
Post-traumatic stress symptoms, parenting stress and mother-child relationships following childbirth and at 2 years postpartum

This study examined the prevalence of childbirth-related post-traumatic stress (PTS) symptoms at 2 years postpartum and the relationship between such symptoms and both self-reported parenting stress and perceptions of the mother-child relationship. 81 women completed measures of childbirth-related PTS symptoms at 6 weeks and 3 months postpartum; these results were used in an exploration of their predictive links with mother-child relationship and parenting measures at 2 years. 17.3% of respondents reported some PTS symptoms at a clinically significant level at 2 years postpartum. However, these symptoms were only weakly linked to parenting stress and were not related to mothers’ perceptions of their children. However earlier PTS symptoms within 3 months of childbirth did show limited associations with parenting stress at 2 years but no association with child relationship outcomes once current depression was taken into account. Implications for clinical practice and the concept of childbirth-related post-traumatic stress disorder are discussed.
Original Brands in Competition Against High Quality Copycats

Purpose Copycat brands offering improved product quality pose serious challenges to original brands. This paper aims to provide a better understanding of why consumers prefer copycat brands with superior product attributes and how original brands can shift this preference back by strategically leveraging brand identity cues. Design/methodology/approach Four experimental studies test different types of brand identity cues that original brands can use to influence consumer preferences. Logistic and linear regression analyses analyze the effects. Findings The results systematically show the power of brand identity cues in helping original brands reduce share loss to copycat brands using superior product attributes. They also reveal the role of brand equity, conspicuous consumption and consumers’ tendency of using brands as status symbols in enhancing the effect of brand identity cues in the face of superior copycats. Research limitations/implications This paper extends cue diagnosticity theory and the brand identity literature by showing the power of brand identity cues in predicting consumer choices of original brands. Practical implications This paper provides useful guidelines for managers of original brands on how to effectively use brand identity cues to compete against copycats. Originality/value Prior research focuses on how copycat brands’ characteristics influence consumers’ evaluations of copycats. These studies are limited, however, by their focus on cheap and low-quality copycats. The current paper examines the effects of brand identity cues and draws attention to the trade-offs consumers make when choosing between original brands and copycats offering superior product features.
Bioactive sesterterpenoids from a Korean sponge Monanchora sp.

Chemical investigation of a Korean marine sponge, Monanchora sp. , yielded nine new sesterterpenoids (1-9) along with phorbaketals A-C (10-12). The planar structures were established on the basis of NMR and MS analysis, and the absolute configurations of 1-9 were defined using the modified Mosher's method and CD spectroscopic data analysis. Compounds 1-8, designated as phorbaketals D-K, possess a spiroketal-modified benzopyran moiety such as phorbaketal A, and their structural variations are due to oxidation and/or reduction of the tricyclic core or the side chain. Compound 9, designated as phorbin A, has a monocyclic structure and is proposed to be a possible biogenetic precursor of the phorbaketals. Compounds 1-9 were evaluated for cytotoxicity against four human cancer cell lines (A498, ACHN, MIA-paca, and PANC-1), and a few of them were found to exhibit cytotoxic activity.
Apprentissage pour l'Accès Opportuniste au Spectre : Prise en Compte des Erreurs d'Observation

Le contexte considere est celui de l'Acces Opportuniste au Spectre. On suppose qu'il existe un utilisateur dit ''secondaire'' interesse par une bande de frequence dediee a un reseau d'utilisateurs prioritaires dits ''primaires''. Les capacites d'ecoute et d'exploitation du spectre de l'utilisateur secondaire sont supposees limitees a une sous-bande de la bande de frequences sondee. Dans une precedente etude, les auteurs avaient suggere une classe d'algorithme d'apprentissage par renforcement, connue sous le nom d'Upper Confidence Bound Algorithms, pour repondre a cette problematique. Le mecanisme d'apprentissage repose essentiellement sur l'observation de l'activite des utilisateurs primaires dans les bandes spectrales sollicitees par l'utilisateur secondaire. L'objectif de ce papier est d'evaluer l'impact des erreurs d'observations de la presence ou absence des utilisateurs primaires sur les performances d'apprentissage de l'utilisateur secondaire. Ces travaux montrent que la convergence vers le canal dit ''optimal'', i.e., le plus libre en probabilite, reste rapide malgre les erreurs d'observation liees a la detection des utilisateurs primaires. Ce resultat est mis en avant a travers un theoreme qui montre que le temps passe par l'algorithme a observer un canal sous-optimal est borne par une fonction logarithmique du temps. Ainsi, les pertes de performances dues aux erreurs d'observations sont quantifiees en fonction des caracteristiques du capteur (probabilite de fausses alarmes notamment). Ces resultats sont illustres a l'aide de simulations.
Potentiation by adrenaline of agonist-induced responses in normal human platelets in vitro

Adrenaline is not a true platelet agonist, but enhances aggregation, dense granule secretion, and phospholipase C induced by other agonists. In the present work we investigated the effect of adrenaline on other platelet responses. It strongly potentiated ADP-induced shape change in platelet-rich plasma, particularly when aggregation was prevented by EDTA. The degree of potentiation increased with increasing concentrations of ADP. Thrombin-induced α-granule secretion, measured by the release of fibrinogen in gel-filtered platelets, was also potentiated by adrenaline at thrombin concentrations above 0.05 U/ml. In contrast, adrenaline had little effect on thrombin-induced secretion of β-acetyl-hexosaminidase and potentiated very little liberation of arachidonate at high thrombin concentrations. When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A2 and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A2 receptor. Protein tyrosine phosphorylation by both thrombin and collagen was reduced by adrenaline, and inhibitors of autocrine stimulation counteracted this reduction.
Expression levels of Mycobacterium tuberculosis antigen‐encoding genes versus production levels of antigen‐specific T cells during stationary level lung infection in mice

Mycobacterium tuberculosis lung infection in mice was controlled at an approximately stationary level after 20 days of log linear growth. Onset of stationary level infection was associated with the generation by the host of T helper type 1 (Th1) immunity, as evidenced by the accumulation of CD4 Th1 cells specific for the early secretory antigen (ESAT‐6) of M. tuberculsosis encoded by esat6, and for a mycolyl transferase (Ag85B) encoded by fbpB. CD4 T cells specific for these antigens were maintained at relatively high numbers throughout the course of infection. The number of CD4 T cells generated against ESAT‐6 was larger than the number generated against Ag85B, and this was associated with a higher transcription level of esat6. The total number of transcripts of esat6 increased during the first 15 days of infection, after which it decreased and then approximately stabilized at 106·5 per lung. The total number of fbpB transcripts increased for 20 days of infection before decreasing and then approximately stabilizing at 104·8 per lung. The number of transcripts of esat6 per colony‐forming unit of M. tuberculosis fell from 8·6 to 0·8 after day 15, and of fbpB from 0·3 to less than 0·02 after day 10, suggesting that at any given time during stationary level infection the latter gene was expressed by a very small percentage of bacilli. Expressed at an even lower level was an M. tuberculosis replication gene involved in septum formation (ftsZ), indicating that there was no significant turnover of the M. tuberculosis population during stationary level infection.
[Arthroscopic single bundle anterior cruciate ligament anatomical reconstruction with remnant preservation].

OBJECTIVE To investigate the feasibility and clinical effects of single bundle anterior cruciate ligament anatomical reconstruction with remnant preservation. METHODS From October 2007 to November 2009, 17 patients (10 male and 7 female, ranging in age from 28 to 62 years, with an average of 39.3 years) with posterior cruciate ligament injuries were treated with single bundle anatomical reconstruction with remnant preservation. Nine patients had the injuries caused by traffic accident; 6 patients caused by falling down; and 2 patients caused by sports injuries. The average time from injury to surgery was 8.5 days (ranging from 2 to 14 days). The international knee documentation committee knee evaluation form (IKDC) and Lysholm were used to analysis the effect of surgery. RESULTS All the patients obtained the follow-up and the average time was 29.5 months (ranging from 24 to 39 months). There were no complications such as injuries of popliteal fossa artery, tibial nerves or peroneal nerve. Twelve patients had knee joint recovering to normal; 1 patient had stiff joints and was treated with arthroscopic surgery to release after 6 months,who had postoperative flexion lack of 20 degree and straight to normal. Three patients had flexion loss of 5 to 10 degree, and 1 patient had hyperextension limitation of 5 degree. Posterior drawer test in 17 patients and the Lachman test were negative. IKDC scores of the 17 patients achieved normal(16 patients) or near normal(1 patient). IKDC overall score normal in 16 patients (94.1%), close to normal in 1 case (5.9%). The IKDC subjective score was 94.3+/-5.1 and Lysholm score was 94.7+/-3.1 at the latest follow-up. CONCLUSION The single bundle anterior cruciate ligament with remnant preservation anatomical reconstruction can provide good clinical results.
Performance and Effects of Linear Feedback Stock Trading Strategies

English) In efficient markets, it is not possible for any trader to look into the future in such a way that the trader can expect excess returns. Whether this hypothesis is true or false is highly discussed in the economics literature. The work at hand investigates a very close topic: Is is possible to construct predictable trading rules—by use of control techniques—that let the trader expect an excess return. In this work, we summarize the literature on efficient markets, introduce the reader to the mathematical field of stochastic analysis, which is needed to understand which trading rules are allowed and which are not, review the literature on feedback trading, and give several examples. Because it is important for the analysis of feedback-backed stock trading strategies, we prove a new Fubini-type theorem, which allows to switch the expectation operator and the Itō integral (for semimartingales), if some conditions are fulfilled like in expectation linear integrators. In the main part, the properties of control-based trading rules known from the literature—like the robust positive expectation property—are extended to much more general market models. The thesis is concluded by an analysis of the impact of feedback-based trading strategies to market stability and a discussion of the obtained results.
Relay Risk; Examining the Communication of Environmental Risk through a Case Study of Domestic Wastewater Treatment Systems in the Republic of Ireland

EPA-ReportCover-167-Jan16-v7.indd 1 15/02/2016 14:05 www.epa. ie The report examines the elements required for the preparation, implementation, and monitoring of an engagement strategy aimed at communicating risk-based environmental regulation of domestic wastewater treatment systems to owners of such systems. The report is aimed at regulators, national and local authorities, and policy makers, particularly those involved in environmental risk communication, management and assessment.
Phenomenologie et thermodynamique : couplages entre thermoelasticite, plasticite, vieillissement et endommagement

Les potentiels utilises pour la determination des lois de comportement des materiaux solides sont construits a partir des notions de couplages d'etat, de dissipation et d'evolution. Une application est donnee dans le cas du comportement elastoplastique couple au vieillissement. Les couplages de dissipation de la plasticite sont etudies a partir de la determination du domaine d'elasticite. L'ecrouissage multiaxial est analyse pour construire les couplages d'etat de l'ecrouissage
Should postpartum depression be targeted to improve child mental health?

OBJECTIVE To evaluate whether postpartum depression (PD) is an appropriate target to prevent poor child outcomes. METHOD Criteria are proposed for evaluating the appropriateness of targeting PD. The target factor should (1) be a causal factor for the negative outcome, (2) have high attributable risk for the negative outcome, (3) be alterable, and (4) be easily and accurately identified through screening. The associated intervention should (5) have characteristics to facilitate dissemination, (6) have low risk for adverse impact, and (7) be acceptable to key stakeholders. RESULTS PD is given a mixed endorsement as an appropriate target for a prevention intervention. Positive characteristics include that PD is moderately prevalent, it is linked with poor child outcomes, it requires inexpensive screening for detection, it is alterable through treatment interventions that may be realistically disseminated, and its treatment is likely to have popular and political support. However, efforts to detect syndromal depression may be costly, strength of the link between PD and poor child outcomes is undetermined, and risks associated with the intervention have not been investigated. CONCLUSIONS Further study is required to assess the appropriateness of PD as a prevention target for improving child outcomes. These provisional criteria may be useful for evaluating other proposed prevention targets.
A system for computer generated movies

With the recent developments in fast hidden surface algorithms and a method for smooth shading of half-tone pictures, it has become feasible to generate useful movies with the computer. This paper describes a system used to make computer generated movies. It also explains the methods used to attempt to solve the problems of object representation, object manipulation, concurrent motion, and ease of specifying motion. The system was first used to make a movie of a hand that lasts for little more than a minute.
Human activity recognition using wearable accelerometer sensors

Human Activity recognition has a wide range of applications such as remote patient monitoring, rehabilitation and assisting disables. Physical activity reduces the risk of many chronic diseases and is consider as a key factor for healthy life. In order to improve the state of global healthcare, numerous healthcare devices has been introduced that allows doctors to perform remote monitoring and increase users' motivation and awareness. Real time activity recognition systems encourage users to adopt healthier life style by increasing personal awareness about physical activities and its positive consequences on health. In this paper a machine learning based technique is proposed to enhance the accuracy of activity recognition system using feature selection method on an appropriate set of statistically derivedfeatures. A publically available HAR dataset on physical activities has been used in this work. Linear forward selection method is employed for feature selection. Activity classification is performed using Random forest and decision tree in connection with AdaBoost. The proposed technique outperforms the recent works.
Pulmonary Vascular Impedance in the Dog

Pulmonary vascular hydraulic input impedance was measured in 13 anesthetized openchest dogs with normal sinus rhythm, and 2 dogs with surgically induced atrioventricular block, by means of electromagnetic flowmeters and strain gauge manometers of known frequency response. The linearity of the pulmonary bed was evaluated by measuring impedance while the heart rate, and hence the pulsatile input to the bed, was varied. The pulmonary bed behaved as a quasilinear system, within the limits of accuracy of the methods employed and the range of frequencies tested. The use of input impedance, or oscillatory pressure/flow ratio, to describe some characteristics of the bed is therefore justifiable, and analogies with linear models like the simple transmission line are not unreasonable. The characteristic input impedance averaged 3,094 dyne sec cm−5 kg, or about one-third the magnitude of the pulmonary vascular resistance, and was therefore a significant part of the total opposition that must be overcome in moving blood through the lungs. This impedance to pulsatile flow is not included in calculations of resistance from mean pressure and flow measurements. The pattern of the impedance spectrum suggested that reflections originating from arteries 1.0 mm and less in diameter play a large role in determining input impedance and its variations with frequency. Pulmonary vasoconstriction by 5-hydroxytryptamine (serotonin) altered the impedance pattern in a manner consistent with increased wave reflection and displacement of the dominant reflecting sites to positions nearer the main pulmonary artery. Capillary compression by increased intra-alveolar pressure also increased reflection, but did not alter the sites of reflection significantly, providing further evidence that the normal impedance pattern and its modification by serotonin are both determined by the characteristics of the arterial part of the bed.
Changes in rheological properties during anaerobic digestion of activated sludge

Wykonane pomiary wlaściwości reologicznych osadwo nadmiernych poddawanych procesowi dezintegracji mechanicznej wskazują na znaczny spadek lepkości siegający 60%. Wraz ze stopniem dezintegracji rosly rowniez wlaściwości pseudoplastyczne oraz malala granica plyniecia. Podobnie istotne zmiany wlaściwosci reologicznych nastepowaly w osadach poddawanych fermentacji metanowej.
Impact of Supply Chain Flexibility and Supplier Development on Supply Chain Effectiveness in Automotive Industry of Pakistan

The purpose of this research is to study the significance of supply chain strategies namely supplier development and supply chain flexibility towards supply chain effectiveness in automotive industry of Pakistan. A survey was conducted using self-administered questionnaires to collect data from 300 supply chain professionals working in automotive manufacturing companies of Pakistan. The finding indicates that supplier development and supply chain flexibility have positive and significant impact on supply chain effectiveness in automotive industry of Pakistan. The research will help policy makers and management to integrate strategies and practices related to supplier development and flexibility to improve supply chain effectiveness in order to be competitive in automotive industry of Pakistan.
Oversimplification in the Study of Emotional Memory

Abstract This Short Review critically evaluates three hypotheses about the effects of emotion on memory: First, emotion usually enhances memory. Second, when emotion does not enhance memory, this can be understood by the magnitude of physiological arousal elicited, with arousal benefiting memory to a point but then having a detrimental influence. Third, when emotion facilitates the processing of information, this also facilitates the retention of that same information. For each of these hypotheses, we summarize the evidence consistent with it, present counter-evidence suggesting boundary conditions for the effect, and discuss the implications for future research. (JINS, 2013, 19, 1–9)
Image Mixing in Multiview Three-Dimensional Imaging Systems

A two-dimensional quality function for quantifying the quality of images observed at viewing regions in contact-type multiview three-dimensional imaging systems is devised and its effectiveness is verified experimentally. The function allows calculating the qualities of images projected to viewers' each eye at any viewing region of the systems. The images observed at each viewing region reveal that different parts of the display panel of the system project different view images. This experimental result matches with the function's prediction.