Miracle-dz/UniFAR-FTUs huggingface dataset:
The Acetyltransferase Activity of CBP Is Required for wingless Activation and H4 Acetylation in Drosophila melanogaster

ABSTRACT CBP is a critical coactivator of transcription, but little is understood about the importance of its intrinsic acetyltransferase (AT) activity in gene activation in vivo. We show that the intrinsic AT function of CBP in Drosophila melanogaster (dCBP) is necessary to maintain a dCBP overexpression phenotype in the eye, for the in vivo activation of a specific target gene, wingless, and for the global acetylation of histone H4. These findings indicate that a point mutation which alters the intrinsic AT activity of CBP (only one of many CBP functions) has profound effects on CBP-induced gene activation in a physiologically intact transcription system. Furthermore, the effects of CBP AT activity are not limited to a few specific promoters, but rather CBT AT activity may play a role in regulating global histone acetylation throughout the developing organism.
YsbA and LytST are essential for pyruvate utilization in Bacillus subtilis

The genome of Bacillus subtilis encodes homologues of the Cid/Lrg network. In other bacterial species, this network consists of holinand antiholin-like proteins that regulate cell death by controlling murein hydrolase activity. The YsbA protein of B. subtilis is currently annotated as a putative antiholin-like protein that possibly impedes cell death, whereas YwbH is thought to act as holin-like protein. However, the actual functions of YsbA and YwbH in B. subtilis have never been characterized. Therefore, we examined the impact of these proteins on growth and cell death in B. subtilis. We did not find a connection to the regulation of programmed cell death, but instead, our experiments reveal that YsbA and its two-component regulator LytST are essential for growth on pyruvate. Moreover, deletion of ysbA and lytS significantly reduces pyruvate consumption. Our findings suggest that LytST induces ysbA transcription in the presence of pyruvate, and that YsbA is involved in pyruvate utilization presumably by functioning as pyruvate uptake system. We show that B. subtilis excretes pyruvate as overflow metabolite in rich medium, indicating that pyruvate could be a common nutrient in the environment. Hence, YsbA and LytST might play a major role in environmental growth of B. subtilis.
Control techniques analysis of DC-DC converter for photovoltaic application using SIMSCAPE

This paper presents design and simulation of a dc -dc boost converter for photovoltaic solar system, using two different control techniques, using SIMSCAPE. SIMSCAPE is software used for simulation of PV cell and panel. A photovoltaic solar system exhibits nonlinear voltage-current characteristic and it varies with solar insolation and temperature. Also maximum power output of PV array varies with the change in temperature and insolation conditions. A DC-DC boost converter efficiently converts DC voltage to a higher voltage, and is also used for PV maximum power tracking purpose to obtain maximum power possible from PV solar system. This paper proposes step by step process of designing and simulation of DC to DC boost converter for a Solar panel of 12 Volts open circuit voltage, 50 Ampere short circuit current and a load of 120 ohms. The DC to DC converter is first simulated at a switching frequency of 100 kHz using PWM controller and then the same converter is simulated using hysteresis controller.
A Reversible Data Hiding with Contrast Enhancement of Digital Image

Existing image-based Reversible Data Hiding (RDH) methods tend to focus on increasing embedding capacity, but few consider keeping or improving visual image quality. A new RDH method with contrast enhancement (RDH-CE) is, by pair-wisely expanding the histogram to the lower end to upper end. RDH-CE is especially valuable in exploiting the details of poorly illustrated images for which the visibility of image details is more important than just keeping PSNR high. However, obvious visual image distortion appears when embedding level gets high, and embedding capacity is relatively low when embedding level is small. In this paper, Wu et al.'s work is improved from four perspectives, namely image contrast enhancement, visual distortion reduction, encryption/decryption of image, and embedding capacity increment. The image contrast is improved by making the histogram shifting process adaptive to the histogram distribution characteristics, the image visual distortion is reduced by cutting off half the modification range of pixels induced in histogram pre-shifting, and the embedding capacity is increased by exploiting the pixel value ordering technique at the early stage of data embedment. A simulation result proves that the proposed work is effective in improving image contrast, reducing visual image distortion, and increasing embedding capacity. The proposed system obtained a peak signal-to-noise ratio (PSNR) of about 1–2 dB greater than the original image.
American Options on High Dividend Securities: A Numerical Investigation

I document a sizeable bias that might arise when valuing out of the money American options via the Least Square Method proposed by Longstaff and Schwartz (2001). The key point of this algorithm is the regression-based estimate of the continuation value of an American option. If this regression is ill-posed, the procedure might deliver biased results. The price of the American option might even fall below the price of its European counterpart. For call options, this is likely to occur when the dividend yield of the underlying is high. This distortion is documented within the standard Black–Scholes–Merton model as well as within its most common extensions (the jump-diffusion, the stochastic volatility and the stochastic interest rates models). Finally, I propose two easy and effective workarounds that fix this distortion.
Fault prediction of power system distribution equipment based on support vector machine

Aiming at the problem of low efficiency in the utilization and analysis of massive data in power system operation and maintenance, combined with the characteristics of operation and maintenance management of power distribution equipment, a fault prediction solution for power distribution equipment based on support vector machine algorithm is proposed. By learning the features of existing data, a predictive model is constructed, and early warning information is sent to the abnormal part of the newly acquired data to implement the fault pre-judgment function of the power distribution equipment.
TQM IMPLEMENTATION EFFECT ON BAHRAIN INDUSTRIAL PERFORMANCE

Research studies on the implementation of Total Quality Management (TQM) demonstrated that the program can improve organizations competitive abilities and provide strategic quality advances. However, limited empirical studies and research have been conducted in Bahrain evaluating the effectiveness of TQM implementation on the industrial organizations performance. Accordingly, this paper aims to measure the degree of TQM implementation in the industrial organizations in Bahrain and its effect on their performance. The paper presents the measurement indicators used to assess the degree of TQM implementation in Bahrain industry, and the main performance indicators affected by it. The adopted research methodology is a survey based on selfcompletion questionnaires. The study led to the identification of the operational and strategic measurement indicators and success factors that assist in successful TQM implementation and performance improvement. The research analysis confirmed a significant positive relationship between the examined performance indicators in Bahrain industry and TQM implementation, and highlighted the key performance improvements.
Perineal care Search date April 2007

INTRODUCTION: Over 85% of women having a vaginal birth suffer some perineal trauma. Spontaneous tears requiring suturing are estimated to occur in at least a third of women in the UK and USA, with anal sphincter tears in 0.5% to 7% of women. Perineal trauma can lead to long-term physical and psychological problems. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions:What are the effects of intrapartum surgical and non-surgical interventions on rates of perineal trauma? What are the effects of different methods and materials for primary repair of firstand second-degree tears and episiotomies? What are the effects of different methods and materials for primary repair of obstetric anal sphincter injuries (thirdand fourth-degree tears)? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2007 (BMJ Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 38 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: active pushing, spontaneous pushing, and sustained breath-holding (Valsalva) method of pushing; continuous support during labour; conventional suturing; different methods and materials for primary repair of obstetric anal sphincter injuries; episiotomies (midline and mediolateral incisions); epidural analgesia; forceps; methods of delivery (“hands-on” method, “hands poised”); water births; non-suturing of muscle and skin (or perineal skin alone); passive descent in the second stage of labour; positions (supine or lithotomy positions, upright position during delivery); restrictive or routine use of episiotomy; sutures (absorbable synthetic sutures, catgut sutures, continuous sutures, interrupted sutures); and vacuum extraction.
Synthetic Biology Ethics: A Deontological Assessment

In this article I discuss the ethics of synthetic biology from a broadly deontological perspective, evaluating its morality in terms of the integrity of nature, the dignity of life and the relationship between God and his creation. Most ethical analyses to date have been largely consequentialist in nature; they reveal a dual use dilemma, showing that synbio has potential for great good and great evil, possibly more so than any step humanity has taken before. A deontological analysis may help to resolve this dilemma, by evaluating whether synbio is right or wrong in itself. I also assess whether deontology alone is a sufficient methodological paradigm for the proper evaluation of synbio ethics.
Automated Detection of Urban Flooding from News

Although minor overflows do not cause a huge amount of loss; as the number of such overflows increases, the amount of water wasted, and the compound consequent challenges become considerable. Therefore, detecting overflows, investigating their cause root and resolving them in a timely manner are among new needs for infrastructure managers. This paper suggests a new method for detecting distributed water overflows by extracting the flood information (such as the date and location of the incident) from the news. As a case study, we crawled Montreal newspaper and news websites to detect the related news to urban flooding and their detailed information. We trained several classifiers to identify news relevant to flood. Our experiments illustrate that by applying mutual information method for feature selection and employing support vector machine (SVM) architecture as the classifier, relevant news can be detected with an accuracy (F-measure) of above 80%. Such actionable information can help infrastructure managers with a wide range of decisions from repair and maintenance of existing systems, to capacity evaluation for new designs.
Patient experiences: a systematic review of quality improvement interventions in a hospital setting

Purpose: In the era of value-based healthcare, one strives for the most optimal outcomes and experiences from the perspective of the patient. So, patient experiences have become a key quality indicator for healthcare. While these are supposed to drive quality improvement (QI), their use and effectiveness for this purpose has been questioned. The aim of this systematic review was to provide insight into QI interventions used in a hospital setting and their effects on improving patient experiences, and possible barriers and promoters for QI work. Methods: Prisma guidelines were used to design this review. International academic literature was searched in Embase, Medline OvidSP, Web of Science, Cochrane Central, PubMed Publisher, Scopus, PsycInfo, and Google Scholar. In total, 3,289 studies were retrieved and independently screened by the first two authors for eligibility and methodological quality. Data was extracted on the study purpose, setting, design, targeted patient experience domains, QI strategies, results of QI, barriers, and promotors for QI. Results: Twenty-one pre–post intervention studies were included for review. The methodological quality of the included studies was assessed using a Critical Appraisal Skills Program (CASP) Tool. QI strategies used were staff education, patient education, audit and feedback, clinician reminders, organizational change, and policy change. Twenty studies reported improvement in patient experience, 14 studies of the 21 included studies reported statistical significance. Most studies (n=17) reported data-related barriers (eg, questionnaire quality), professional, and/or organizational barriers (eg, skepticism among staff), and 14 studies mentioned specific promoters (eg, engaging staff and patients) for QI. Conclusions: Several patient experience domains are targeted for QI using diverse strategies and methodological approaches. Most studies reported at least one improvement and also barriers and promoters that may influence QI work. Future research should address these barriers and promoters in order to enhance methodological quality and improve patient experiences.
Stated preferences in the digital age : an incremental design to assist recommender systems

Mobile platforms constantly improve their functionalities, offering users a wide set of items along with services that facilitate the selection process. Recommender systems (RS) track the interaction of users with items or transfer information from like-minded users with the objective to construct a behavioural model for each user. Typical applications in transport are personalized route RS in multimodal networks [1,2]
Logistics Strategy for Industrialised House Building

Construction Logistics has recently emerged as an important consideration for Industrialized House Building (IHB). Previous research has demonstrated that construction logistics improves IHB through: the clarification of interfaces along the supply chain; increased supply chain efficiency; more productive construction sites; the transfer of value-adding activities from site to the supply chain; and the integration of site and supply chain. IHB research has commonly focused on buildings as product, their technical design and production, as well as the process of these activities. IHB companies seek the integration of these two aspects. However, there is growing realization of the value of integrating the supply chain through a focus on logistics. This paper argues that in order to achieve a tripartite integration of product, process, and logistics, that first an overarching company-level logistics strategy is required. A strategic perspective enables a separation of high-level logistics decisions from those that are operational in nature, in the same way that product platforms have assisted IHB. This separation is critical in overcoming the peculiarities of construction. This authors identify design-thinking as a powerful tool to assist in the future implementation of logistics strategy in order to drive the creation of contextually specific logistics solutions. Two company case studies from Sweden reveal two distinct forms of logistics strategy. These case studies, through comparative analysis, show how logistics strategies for IHB might emerge as design-led ‘logistics platforms’ that utilize the principles of standardization, modularity, and re-usability in order to achieve the flexibility demanded by construction. This paper proposes that a focus on IHB logistics strategy as a platform be implemented to allow effective integration of construction’s supply chain. The result of this approach is a re-usable, continually improving platform for construction logistics that can co-ordinate differing product and process approaches.
THEORY OF STELLAR STRUCTURE AND EVOLUTION

(1) Theory of thermally pulsing AGB stars During the past years particular care has been devoted to study in detail the structure and evolution of thermally pulsing AGB stars up to the planetary nebula stage. They bear very much on a number of problems going from the correct luminosity function of Carbon stars in galaxies of the Local Group, to the interpretation of the Color-Magnitudes Diagrams of cool stars in external galaxies, to the chemical enrichment of the interstellar medium.
A Pragmatic Approach to On-Line Testing

Modeling and simulation of time domain faults in digital systems p. 5 Sizing CMOS circuits for increased transient error tolerance p. 11 Low-area on-chip circuit for jitter measurement in a phase-locked loop p. 17 Necessary and sufficient conditions for the existence of totally self-checking circuits p. 25 Self-checking code-disjoint carry-select adder with low area overhead by use of add1-circuits p. 31 A hierarchical self test scheme for SoCs p. 37 Single-output embedded checkers for systematic unordered codes p. 45 A new dynamic circuit design technique for high performance TSC checker implementations p. 52 New high speed CMOS self-checking voter p. 58 Concurrent error detection in sequential circuits implemented using FPGAs with embedded memory blocks p. 67 Low cost on-line testing of RF circuits p. 73 Hybrid soft error detection by means of infrastructure IP cores p. 79 A comparative study of the design of synchronous and asynchronous self-checking RISC processors p. 89 Testing of hard faults in simultaneous multihreaded processors p. 95 Fault detection enhancement in cache memories using a high performance placement algorithm p. 101 Transient fault emulation of hardened circuits in FPGA platforms p. 109 On the evaluation of SEU sensitiveness in SRAM-based FPGAs p. 115 Asynchronous circuits sensitivity to fault injection p. 121 Designing a high speed decoder for cyclic codes p. 129 Impact of ECCs on simultaneously switching output noise for on-chip busses of high reliability systems p. 135 A signed digit adder with error correction and graceful degradation capabilities p. 141 A novel fault tolerant cache to improve yield in nanometer technologies p. 149 Scrubbing away transients and jiggling around the permanent : long survival of FPGA systems through evolutionary self-repair p. 155 Hardware reconfiguration scheme for high availability systems p. 161 Operating system function reuse to achieve low-cost fault tolerance p. 167 A new code with reduced EMI and partial EC possibilities p. 175 A Matlab based on-chip signal generation and analysis environment for mixed signal circuits p. 176 Automated logic SER analysis and on-line SER reduction p. 177 On the design of long-life reliable systems for ground-based applications p. 178 On-line monitoring capabilities of oscillation test techniques : results demonstration in an OTA p. 179 An intrinsically robust technique for fault tolerance under multiple upsets p. 180 Survey of the algorithms in the column-matching BIST method p. 181 A technique to reduce power and test application time in BIST p. 182
Molecular basis of functional voltage‐gated K+ channel diversity in the mammalian myocardium

In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+) currents contribute importantly to shaping the waveforms of action potentials, and several distinct types of voltage‐gated K+ currents that subserve this role have been characterized. In most cardiac cells, transient outward currents, Ito,f and/or Ito,s, and several components of delayed reactivation, including IKr, IKs, IKur and IK,slow, are expressed. Nevertheless, there are species, as well as cell‐type and regional, differences in the expression patterns of these currents, and these differences are manifested as variations in action potential waveforms. A large number of voltage‐gated K+ channel pore‐forming (α) and accessory (β, minK, MiRP) subunits have been cloned from or shown to be expressed in heart, and a variety of experimental approaches are being exploited in vitro and in vivo to define the relationship(s) between these subunits and functional voltage‐gated cardiac K+ channels. Considerable progress has been made in defining these relationships recently, and it is now clear that distinct molecular entities underlie the various electrophysiologically distinct repolarizing K+ currents (i.e. Ito,f, Ito,s, IKr, IKs, IKur, IK,slow, etc.) in myocyardial cells.
Estimating Primary Mass Composition of Cosmic Rays Using Geomagnetic Spectroscopy

The distortion of the muon component by the geomagnetic field is more complex than the deflection of a single muon generated in the atmosphere. From a detailed Monte Carlo simulation of the propagation of muons of positive and negative charge in EAS, it is found that the muonic dipole length is quite sensitive to the mass of the primary particle, particularly for inclined showers. New possibilities are inferred in the case of very inclined showers simulated with the CURVED option of CORSIKA, particularly considering high energy muons.
AN ANALYSIS OF ARMORED SHORELINES AS BARRIERS FOR COASTAL VEGETATION

To combat coastal erosion from disrupting human development, coastlines are physically armored for coastal stabilization, but ecological impacts of installing these anthropogenic structures are typically ignored. This study aims to measure the biotic response of coastal vegetation to armored coastline in comparison to natural, undisturbed coastline. 4 quadrats per coastal type were randomly sampled at 8 paired sites of adjacent natural and artificial coast were surveyed to record abundance of mature woody and herbaceous plants, seedlings, seeds, soil texture, and crab hole abundance. Species richness and abundance of seeds and seedlings of woody, ocean-dispersed plants were higher along natural coastlines, but species richness and abundance of herbaceous plant species were higher along armored shorelines. Both natural and rock wall coastlines share similarities in composition, but each coastal type houses different types of plants. Higher seed and seedling abundance of native, coastal, and woody oceandispersed-plants along natural coastline suggest armored shorelines pose challenges for new recruits to successfully deposit and establish.