Miracle-dz/UniFAR-FTUs huggingface dataset:
Alzheimer’s Imaging Consortium Poster Presentations: IC-P P94 IC-P-158 IN VIVO PATTERN OF TAU AND BETA-AMYLOID DEPOSITION IN THE BRAIN MIGHT DISTINGUISH HEALTHY INDIVIDUALS FROM THOSE WITH PRECLINICAL ALZHEIMER’S DISEASE

IC-P-158 IN VIVO PATTERN OF TAU AND BETA-AMYLOID DEPOSITION IN THE BRAIN MIGHT DISTINGUISH HEALTHY INDIVIDUALS FROM THOSE WITH PRECLINICAL ALZHEIMER’S DISEASE Victor Villemagne, Shozo Furumoto, Michelle Fodero-Tavoletti, Rachel S. Mulligan, Ryuichi Harada, Paul Yates, Svetlana Pejoska, Kazuhiko Yanai, Colin Masters, Yukitsuka Kudo, Christopher Rowe, Nobuyuki Okamura, Austin Health, Melbourne, Australia; Tohoku University School of Medicine, Sendai, Japan; University of Melbourne, Melbourne, Australia; Tohoku University School of Medicine, Sendai, Japan; Austin Health, Heidelberg, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia; Tohoku University, Sendai, Japan; Austin Health, Melbourne, Australia; Tohoku University School of Medicine, Sendai, Japan. Contact e-mail: villemagne@petnm.unimelb. edu.au
Analysis of Posterior Chain Muscle Symmetry in Junior Badminton Players of South Asia

Badminton is a physically demanding sport and it is not uncommon for players to have muscle imbalances. Detection and prevention of posterior muscle chain imbalances may help prevent injuries and result in overall improvement in performance. Accordingly, the study was proposed to analyse the posterior muscle chain symmetry in junior badminton players and understand the importance of prevention of muscle imbalance. A total of 100 players from South Asia between the ages of 8 and 15 years were analysed. Postural bench MF system of Tec nobody Italy was used. Variables measured were gender, height, age, body mass index, and experience in years, level at which they play, current pain, and clicks & catches in the past 1 year. Our study showed that there is a significant difference in the lumbar load between the right and left side in amateur and professional badminton players and in the pelvic load between the right and left side in players with an experience of less and more than 5 years. Rest of the variables did not prove to be significant with respect to difference in scapular, lumbar and pelvic load. There needs to be a greater focus on prevention of muscle imbalances with the help of specific training, strength & conditioning, and rehabilitation as part of the development of junior badminton players. understanding of mechanisms controlling muscle activation in the presence of low back pain as well as objective ways of measuring and quantifying muscular function in the presence of low back pain. Another study showed the concept of hip muscle imbalance being associated with low back pain occurrence in female athletes. Their research further supported the need for the assessment and treatment of hip muscle imbalance in individuals with low back pain. In a previous study, we assessed hip stability, helping us pin-point the exact region of muscle imbalance and treat it accordingly Manan et al [23].
The role of TiC on the hardness and wear resistance of AA 7075 using GTA

The main objective of this study is to improve the hardness and wear resistance of AA 7075 by reinforcing Titanium Carbide (TiC) particles onto the aluminium alloy surface using Gas Tungsten Arc (GTA) as a heat source. Based on the number of trails, optimum GTA heat source parameters are finalized with reference to the proper fusion of base metal. After TiC is deposited onto the surface, three step post-weld heat treatment (PWHT) was employed to improve the hardness and wear resistance. The material was solution treated followed by water quenching and artificially aged. The Dry sliding wear tests were conducted using a pin on disc wear testing equipment and the wear rates were calculated by using weight loss method. An inverse relationship was found between wear rate and hardness. The increase in the microhardness was found to be 33 %. The wear rate increased with increase in the load but reduced with respect to increasing sliding velocity. The variation of COF with hardness was found to be almost constant. A detailed material characterization of as received AA 7075, after TiC reinforcement and after heat treating AA 7075 substrate was done using Scanning Electron Microscope (SEM), line Energy dispersive X ray spectrometry (Line-EDX) and X-ray diffraction (XRD) techniques.
Regulation ofnetrin-1aExpression by Hedgehog Proteins

Netrins,a family of growth cone guidance molecules, are expressed both in the ventral neural tube and in subsets of mesodermal cells. In an effort to better understand the regulation ofnetrins,we examined the expression ofnetrin-1ain mutantcyclops, no tail,andfloating headzebrafish embryos, in which axial midline structures are perturbed.Netrin-1aexpression requires signals present in notochord and floor plate cells. In the myotome, but not the neural tube,netrin-1aexpression requiressonic hedgehog.In embryos lackingsonic hedgehog,thesonic-youlocus,netrin-1aexpression is reduced or absent in the myotomes but present in the neural tube. Embryos lackingsonic hedgehogexpresstiggy-winkle hedgehogin the floor plate, suggesting that, in the neural tube,tiggy-winkle hedgehogcan compensate for the lack ofsonic hedgehogin inducingnetrin-1aexpression. Ectopic expression ofsonic hedgehog, tiggy-winkle hedgehog,orechidna hedgehoginduces ectopicnetrin-1aexpression in the neural tube, and ectopic expression ofsonic hedgehogortiggy-winkle hedgehog,but notechidna hedgehog,induces ectopicnetrin-1aexpression in somites. These data demonstrate that in vertebratesnetrinexpression is regulated by Hedgehog signaling.
Application of Collaborative Filtering for Software Component Retrieval System

A search engine for software component helps developers to reuse software component and to understand its behavior. We are studying about a software component search engine and constructs SPARS-J for Java source codes. SPARS-J provides useful information obtained by static analysis of source codes in a repository. However, we also consider that SPARS-J provides more useful information by using the analysis result of its retrieval history. In this paper, we suggest a recommendation method by using collaborative filtering technique, and evaluated the effectiveness of the system implemented of SPARS-J
Experiences of patients with stroke and their caregivers with caregiver-mediated exercises during the CARE4STROKE trial

Abstract Purpose: Caregiver-mediated exercises are a novel way of delivering augmented exercise therapy for patients with stroke, in which patients do additional therapeutic exercises together with a caregiver. This explorative qualitative study is part of the CARE4STROKE trial and focused on how participants manage these exercises together. The research questions were: (1) how do the patient–caregiver couples exercise together? and (2) what does exercising together bring about, besides more hours of practice? Methods: Semi-structured interviews were conducted with patients and caregivers who participated in the CARE4STROKE intervention. Inductive thematic data analysis was applied. Results: Seven patients and seven caregivers were interviewed. Three different role-dynamics were found during caregiver-mediated exercises: (1) patient in control, (2) in concert, and (3) the caregiver as informal carer. In addition, three themes were identified about what exercising together brings about: (a) tailor-made exercises through active involvement, (b) preparation for the home situation, and (c) opportunity to be involved. Conclusion: Different role-dynamics are at play in caregiver-mediated exercises, and it is important for participating staff to be aware of their possible effects on the strain of patient or caregiver. Caregiver-mediated exercises were found to enhance individualization of the treatment plan and preparation for home discharge. Implications for rehabilitation Caregiver-mediated exercises, in which a caregiver does exercises with a patient, are currently under investigation as a new form of augmented exercise delivery after stroke Doing exercises together seems to make patient and caregivers actively involved in rehabilitation, which they appreciate, and which seems to help them prepare for the home situation Caregiver selection and monitoring role-dynamics during exercising is an important task of the rehabilitation team
CNTFR α alone or in combination with CNTF promotes macrophage chemotaxis in vitro

Abstract Microchemotaxis chambers were used to investigate whether one aspect of ciliary neurotrophic factor CNTF’s role as a lesion factor might be to promote the initial early recruitment of macrophages, which express the signal transducing receptor components, gp130 and LIFRβ. CNTFRα alone, or in combination with CNTF, elicited concentration-dependent macrophage chemotaxis that was inhibited by a neutralizing gp 130 antibody. IL-6, but not LIF, similarly promoted gp 130-dependent macrophage chemotaxis. Stimulation of macrophages with either CNTFRα in combination with CNTF or IL-6 alone resulted in tyrosine phosphorylation of a ~130 kD protein, presumed to be gp130. Macrophage chemotaxis induced by the combination of CNTFRα and CNTF was inhibited in a dose-dependent fashion by wortmannin, LY294002 or PD98059, suggesting the involvement of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling proteins. As CNTFRα and CNTF are present, or have immediate access to nerves after injury, these data point to the possibility that this soluble receptor alone or in combination with its ligand may promote the initial early recruitment of macrophages in vivo.
The concept of a strategy of transformation of a functional organization into process organization on the example of car dealerships in Poland

Abstract: The main goal of the article was to characterize the concept of transformation 7 strategy of an organization that is functionally manager into a process organization on the 8 example of authorized car dealerships. The auxiliary purpose was to present the results of the 9 empirical study on the process maturity assessment of authorized dealerships in Poland. The 10 goals were achieved as a result of literature review, analysis of secondary research, 11 observation and opinion poll method. The second part of the article presents the selected 12 definition of process maturity as well as the characteristics of the multidimensional 13 organizational maturity assessment model used. Then, the structure of the research project 14 was characterized. As a result, the results of the empirical investigation were presented, based 15 on which three transformation strategies were formulated: adaptive, developmental and 16 dynamic. As a result of the study, it was found that the examined objects are mostly classified 17 at the second and fifth level of maturity. 18
The Bloomsbury Group

Why should wait for some days to get or receive the the bloomsbury group book that you order? Why should you take it if you can get the faster one? You can find the same book that you order right here. This is it the book that you can receive directly after purchasing. This the bloomsbury group is well known book in the world, of course many people will try to own it. Why don't you become the first? Still confused with the way?
SEarch via Recursive Rejection (SERR): A Connectionist Model of Visual Search

Abstract In studies of visual search, a general distinction is often made between the processes involved when detection of a target is unaffected by the number of distractors in the field and those involved when search time increases linearly as a function of the number of distractors present. In the former case, processes are said to be "pre-attentive" and to operate in parallel across the visual field; in the latter, processing is said to require focal attention and to be spatially serial. In this paper, we present a connectionist model which performs visual search in parallel across a window defining the model′s functional field. Elements in the field are allowed to group, using simple principles of similarity and spatial proximity. Search operates via the recursive rejection of areas of field where stable and unambiguous grouping has been achieved. Performance of the model is unaffected by the number of distractors present when the distractors form a single group. As the number of competing distractor groups increases, there is an increased likelihood that targets are missed. Setting a response criterion to balance miss rates generates serial increases in search time as a function of the number of distractors. These results are shown to match the functions produced when human subjects search displays varying in the number of distractor groups. The implications of the model are discussed, and the results of five experiments are presented that test novel predictions derived from the model.
Pedagoģiski psiholoģisko līdzekļu izvēle mācību darbībā skolēniem ar Aspergera sindromu vispārējās pamatizglītības programmā

Kopsavilkums. Raksta mērķis ir atklāt tās autiskā spektra traucējumu pazīmes, kas ļauj skolēniem iekļauties vispārizglītojošā programmā. Rakstā analizētas autisma pazīmes, noskaidroti dažādi klasifikācijas kritēriji un piedāvāti autisma veidu raksturojumi. Tika konstatēts, ka no autiskā spektra traucējumiem tikai Aspergera sindroms un augsti funkcionējošs autisms ir diagnozes, ar kurām bērni var integrēties un iekļauties vispārizglītojošā skolā, savukārt noteikta pedagoģisko darbību sistēma ļauj veiksmīgi mācīties kopā gan bērniem ar šīm diagnozēm, gan bērniem bez diagnozes un sasniegt pedagoģiskos mērķus. Teorijas aprobācijai izmantota case study metode, ar mērķi konstatēt autiska spektra traucējumu pazīmes un konkrētus pedagoģiskos līdzekļus, kas veicina iekļaušanos un integrāciju.
[Regulatory effect and relevant mechanisms of fraction from heat-clearing and detoxifying herb couplet on macrophage M1/M2 phenotypes].

To explore the regulatory effect and relevant mechanisms of the fraction of Hedyotis diffusa and Scutellaria barbata herb couple(YDW11) on polarization of macrophage between M1/M2 phenotypes.RAW264. 7 cells were induced with LPS/IFN-γ or IL-4/IL-13 to establish M1 or M2 macrophage cell model. MTT assay was used to measure the cell cytotoxicity of YDW11. Griess reaction was used to detect the changes of nitrite accumulation in the cell supernatant. Trans-well assay was used to measure the migration capability. QRT-PCR was used to assay mRNA expressions of iNOS, IL-1β, Arg-1 and MR. Western blot was used to detect the effect of YDW11 on iNOS and Arg-1 protein expressions. Taqman MicroRNA RT-PCR was used to detect the effect of YDW11 on miR155 expression under M1 and M2 phenotype conditions. In addition, MS-UPLC assay was carried out to identify the constituents in YDW11. The results showed that the ethyl acetate of H. diffusa and S. barbata extracted in 1:1 ratio with water (YDW11) showed the activity in suppressing the nitrite content in M1 macrophages without cytotoxicity. YDW11 also inhibited the migration of breast cancer cells with the help of M2 macrophages by blocking their polarization towards M2. YDW11 decreased iNOS, IL-1β, Arg-1and MR mRNA expressions and iNOS and Arg-1 protein expressions. YDW11 down-regulated miR155 expression in M1 phenotype, and up-regulated miR155 expression in M2 phenotype. Based on MS-UPLC,four compounds were identified in YDW11, including 4'-hydroxyacetophenone, scutellarin, luteolin and apigenin. YDW11 inhibited M1/M2 phenotypes of macrophages by regulating the expression of miR155.
Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents

ABSTRACT Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as potent growth inhibitors of the related kinetoplastid Leishmania. Herein, we evaluated the inhibitory activity of a series of 69 indirubin analogues screened against T. cruzi trypomastigotes and intracellular amastigotes. Seven indirubins were identified as potent T. cruzi inhibitors (low μΜ, nM range). Cell death analysis of specific compounds [3'oxime-6-bromoindirubin(6-BIO) analogues 10, 11 and 17, bearing a bulky extension on the oxime moiety and one 7 substituted analogue 32], as evaluated by electron microscopy and flow cytometry, showed a different mode of action between compound 32 compared to the three 6-BIO oxime- substituted indirubins, suggesting that indirubins may kill the parasite by different mechanisms dependent on their substitution. Moreover, the efficacy of four compounds that show the most potent anti-parasitic effect in both trypomastigotes and intracellular amastigotes (10, 11, 17, 32), was evaluated in a mouse model of T. cruzi infection. Compound 11 (3ʹpiperazine-6-BIO) displayed the best in vivo efficacy (1/6 mortality, 94.5% blood parasitaemia reduction, 12 dpi) at a dose five times reduced over the reference drug benznidazole (20 mg/kg vs100 mg/kg). We propose 3ʹpiperazine-6-BIO as a potential lead for the development of new treatments of Chagas disease.
The Effectiveness of Cross-Age Blogging

Introduction:“We didn’t have to do any work! ” was the greatest response to the question asked of fourth and fifth-grade students on what they liked best about the month long cross-age buddy reading and blogging project. A major challenge of candidates and university faculty in teacher education is how to effectively develop children’s digital literacy skills. This research article is available in The Advocate: https://newprairiepress.org/advocate/vol22/iss1/3
Generator‐based threshold for transient stability assessment

Power systems are frequently subjected to variations of the operating conditions due to the occurrence of contingencies such as faults, load or generator tripping. These disturbances might enforce the system to enter the instability region and thus deteriorate its overall performance. This paper proposes a systematic approach for transient stability assessment using generator-based threshold. An individual stability limit is designed for each generator instead of using only one pre-defined threshold for all generators. The considered contingencies are characterized by a fault type, location, loading condition and critical clearing time to consider wide range of operating conditions. Two fault locations are only considered to reduce the search space for stability limits; the generator terminals and mid of transmission lines. The critical clearing time is used to find the maximum relative rotor angle (MRRA) of individual generators attained during the entire time domain simulation. The MRRA of each generator represents the maximum angle which can be reached without losing synchronism at a given contingency. Conservative stability limits are drawn around the minimum stable drift of each generator which is chosen from the set of MRRAs of all contingencies. The effectiveness of the proposed approach is tested using the modified New-England, 39-bus system.
Teacher experiences of delivering an obesity prevention programme (The WAVES study intervention) in a primary school setting

Objective: There has been a wealth of childhood obesity prevention studies in school-based settings. However, few have investigated the experiences of school staff charged with delivery of such programmes. This study aimed to elicit teachers’ experiences of delivering a childhood obesity prevention programme for children aged 6–7 years. Design: Descriptive-interpretive qualitative study. Setting: Primary schools participating in the UK West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES) study. Method: In all, 14 teachers were recruited from 12 primary schools. Semi-structured interviews were conducted and data analysis was guided by the Framework Approach. Results: Teachers recognised the importance of obesity prevention in primary schools. They reported positively on aspects of the intervention, in particular its flexibility and the ready-prepared materials. Time constraints and gaining support of parents were seen as key challenges to intervention delivery. Conclusions: Delivering an obesity prevention programme in school is feasible but challenging for teachers. Our findings suggest that to maximise the likelihood of delivery, interventions should be hands-on, easy to manage and flexible to the needs of individual schools. The perceived importance of the promotion of healthy lifestyle behaviours by schools was evident, but teachers felt restricted in the resources that could be devoted to achieve and encourage this. National combined with local level direction and support for healthy lifestyles in children would help schools to give this the priority it requires.
Detección automática de engaño en notas de opinión a partir de técnicas de perfilado de autores

The present work shows the results achieved by applying a method originally proposed for author profiling to the automatic detection of deception. The method represents each profile (i.e. authors of a certain genre or age range) through sub-profiles for each category. That is, it does not assume that all young people, or all adults, write with the same style. This work takes up the same assumption, and attempts to refine the discrimination between deceptive and true notes, assuming
Problèmes de durée de vie : applications à l'industrie automobile

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The bipedal saddle space: modelling and validation

Better understanding of human balance control is pivotal for applications such as bipedal robots and medical technologies/therapies targeting human locomotion. Despite the inverted pendulum model being popular for describing bipedal locomotion, it does not properly capture the step-to-step transition dynamics. The major drawback has been the requirement for both feet to be on the ground which generates a discontinuity along the intersection of the potential energy surfaces produced by the two legs. To overcome this problem, we propose a generalized inverted pendulum-based model that can describe both single and double support phases. The full characterization of the system’s potential energy allows the proposed model to drop the main limitation. This framework also enables optimal strategies to be designed for the transition between the two feet without the optimization algorithms. The proposed theory has been validated by comparing the human locomotor strategies output of our planner with real data from multiple experimental studies. The results show that our model generates trajectories consistent with human variability and performs better than existing well-known methods.