Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical and Histopathological Study of Diclofenac SodiumAcetylsalicylic Acid Toxic Effect on Liver of Mice

Both over-the-counter (OTC) and prescription analgesics-antipyretics like ibuprofen which is nonsteroidalanti-inflammatory drugs (NSAIDs) have effective as well as safe use for long time. Reversible inhibitionof cyclooxygenase enzymes is the mode of action of NSAIDs over all. Use of NSAID lead to drug adversereactions such as cardiovascular and gastrointestinal bleeding also effects of renal. Drug–drug interactions(DDIs) within the NSAID and a concomitant medication cause adverse drug reaction to several cases.DDIs have been reported for example, when commonly used medications as well as some antihypertensive,alcohol, aspirin, antidepressants are coadministered with NSAIDs. Dependent on total drug exposure causea continuous risk in that the potential for an ADR due to interactions pharmacologic nature. When assessingADRs potential risk is important to consideration the use of NSAID dose and duration, also the comedicationtype or class administered. The sub acute toxicity were carried out on thirty mice divided to three equallygroups (10 mice in sub group) which were dosed for two weeks daily as follows: group one (control) wasgivin distilled water, the group two was get diclofenac (voltaren) (100mg/kg B.W.) and group three wasgivin diclofenac (voltaren) with aspirin (100mg/kg B.W.) for each together. Clinical signs of toxicity appearas following: abdominal pain, nausea, dizziness, anorexia, ataxia, blueness of the chest area, shortness ofbreath and Paralysis of the posterior limbs and recumbence, finally the death of mouse. Serum liver enzyme(ALT and AST) were elevated in all groups (diclofenac and diclofenac with aspirin) as compare to controlafter two weeks. Considering histopathological studies of liver tissue after two weeks of daily treatment,which showed moderated mononuclear cells infiltration in portal area around blood vessels and bile ductfor voltaren group and fatty vacuoles in the cytoplasm of hepatic cells, single cells necrosis and severeinflammatory cells infiltration in the capsular area for voltaren with aspirin group. We concluded thatdiclofenac and diclofenac with aspirin have toxic effect appear by clinical symptoms and damage to liver,furthermore, don’t administration of more than one NSAID at same time.
Optimal V-Plane Robust Stabilization Method for Interval Uncertain Fractional Order PID Control Systems

Robust stability is a major concern for real-world control applications. Realization of optimal robust stability requires a stabilization scheme, which ensures that the control system is stable and presents robust performance for a predefined range of system perturbations. This study presented an optimal robust stabilization approach for closed-loop fractional order proportional integral derivative (FOPID) control systems with interval parametric uncertainty and uncertain time delay. This stabilization approach, which is carried out in a v-plane, relies on the placement of the minimum angle system pole to a predefined target angle within the stability region of the first Riemann sheet. For this purpose, tuning of FOPID controller coefficients was performed to minimize a root angle error that is defined as the squared difference of minimum angle root of interval characteristic polynomials and the desired target angle within the stability region of the v-plane. To solve this optimization problem, a particle swarm optimization (PSO) algorithm was implemented. Findings of the study reveal that tuning of the target angle can also be used to improve the robust control performance of interval uncertain FOPID control systems. Illustrative examples demonstrated the effectiveness of the proposed v-domain, optimal, robust stabilization of FOPID control systems.
Gain Enhancement of Transversely Slotted Substrate Integrated Waveguide Leaky-Wave Antennas Based on Higher Modes

A technique for gain enhancement of transversely slotted substrate integrated waveguide (SIW) leaky-wave antennas is proposed based on higher modes. Two SIW leaky-wave antennas based on the <inline-formula> <tex-math notation="LaTeX">${\mathrm {TE}}_{m0}$ </tex-math></inline-formula> (<inline-formula> <tex-math notation="LaTeX">$m = 3$ </tex-math></inline-formula>, 5) higher modes are investigated. The antennas possess the advantage of simplicity, in which the feeding structures are compact and simple. Compared with published transversely slotted SIW leaky-wave antenna based on the fundamental mode (TE<sub>10</sub> mode), the proposed antennas exhibit higher and more consistent gains. Besides, the antennas maintain the scanning capability from near broadside to endfire. The working principles of the antennas are explained. The propagation characteristics are investigated with a magnetic field integral method. The aperture efficiencies are analyzed. Two leaky-wave antenna designs based on the TE<sub>30</sub> and TE<sub>50</sub> higher modes are demonstrated and compared with a TE<sub>10</sub>-mode antenna design (with almost the same dispersion characteristics). Prototypes of the three designs are fabricated and measured for comparisons. Compared with the TE<sub>10</sub>-mode antenna, the TE<sub>30</sub>- and TE<sub>50</sub>-mode antennas have the transverse beamwidths markedly narrowed and have the gains improved by about 5.5 and 8 dB, respectively.
Paramètres de l'endocrinologie sexuelle des béliers Peuls et Touaregs : influence du type génétique et de la saison

Endocrinal parameters of two sexual hormones [luteinizing hormone (LH) and testosterone] were studied in three Tuareg rams and two bicolor Peul rams during April and October 1997. Blood samples were collected at 15 min intervals from 1h00 to 7h00 AM. Means (± standard error) obtained for the various parameters studied in Peul and Tuareg rams were as follows, respectively: basal levels of testosterone 4.17 ± 1.82 and 4.55 ± 2.71 ng/ml, and LH 0.80 ± 0.13 and 0.96 ± 0.33 ng/ml; peaks of testosterone 10.16 ± 3.11 and 11.09 ± 2.82 ng/ml, and LH 1.75 ± 0.90 and 2.65 ± 1.29 ng/ml; duration of peaks of testosterone 85 ± 18.7 and 88.63 ± 27.47 min, and LH 75 ± 23.71 and 61.87 ± 24.23 min; frequency of peaks of testosterone 2.38 ± 1.3 and 2.03 ± 1.2 peaks/6h, and LH 1.08 ± 0.15 and 1.85 ± 0.97 peaks/6h. Time intervals between the peak of LH and the first significant rise of testosterone were 26.25 ± 6.49 and 31.87 ± 15.79 min, respectively. The only significant (p 0.05). The duration of the peak of LH was significantly affected by the season (p < 0.05), whereas the other parameters were not. Parallel evolutions of the basal levels of testosterone and LH during both seasons highlighted the interaction between the two hormones.
Dinamit Destekli Terör Faaliyetlerinin Önlenmesi İçin Derin Öğrenme Temelli Güvenlik Destek Sistemi

Gunumuz toplumunda, insanlari tehdit eden en onemli etmenlerden birisi terorizmdir. Terorizm bir toplumda, insanlarin duzen durumlarini bozarak, yasam kalitesini etkilemektedir. Devletler ise terorle mucadele etmek icin surekli farkli yontemler gelistirmektedir. Bu yontemlerden birisi de terorle mucadele icin makine ogrenmesinin bir alt alani olan derin ogrenmenin kullanilmasidir. Derin ogrenme, makine ogrenmesi alaninda son yillarda oldukca populerlik kazanmistir. Bu calismada, teror faaliyetlerini fark etmek ve onlemek icin derin ogrenmeye dayali VGG-16 mimarisi temel alinarak yeni bir model onerilmektedir. Onerilen model ile guvenlik kontrollerinde kullanilan kamera goruntulerinden alinan goruntulerde, insan ya da tren raylari uzerinde dinamit tespit edildiginde, durumu hizla belirlemek ve uygun onlemleri almak icin guvenlik gorevlilerini uyaran bir sistem gerceklestirilmistir. Calismada kullanilan veri seti, internet ortamindan indirilen dinamit resimleri duzenlenerek olusturulmustur. Onerilen modelin performansini degerlendirmek icin, insan ya da tren raylari uzerinde bulunan dinamit resimleri test edilerek, %98,4’luk basari dogrulugu ve 0,024 kayip oraniyla dinamit goruntuleri tespit edilmektedir.
Deep generative models for ligand‐based de novo design applied to multi‐parametric optimization

Multi‐parameter optimization (MPO) is a major challenge in new chemical entity (NCE) drug discovery. Recently, promising results were reported for deep learning generative models applied to de novo molecular design, but, to our knowledge, until now no report was made of the value of this new technology for addressing MPO in an actual drug discovery project. In this study, we demonstrate the benefit of applying AI technology in a real drug discovery project. We evaluate the potential of a ligand‐based de novo design technology using deep learning generative models to accelerate the obtention of lead compounds meeting 11 different biological activity objectives simultaneously. Using the initial dataset of the project, we built QSAR models for all the 11 objectives, with moderate to high performance (precision between 0.67 and 1.0 on an independent test set). Our DL‐based AI de novo design algorithm, combined with the QSAR models, generated 150 virtual compounds predicted as active on all objectives. Eleven were synthetized and tested. The AI‐designed compounds met 9.5 objectives on average (i.e., 86% success rate) versus 6.4 (i.e., 58% success rate) for the initial molecules measured on all objectives. One of the AI‐designed molecules was active on all 11 measured objectives, and two were active on 10 objectives while being in the error margin of the assay for the last one. The AI algorithm designed compounds with functional groups, which, although being rare or absent in the initial dataset, turned out to be highly beneficial for the MPO.
Synthesis and characterization of biocompatible Fe3O4 nanoparticles at different pH

Gene therapy is a promising therapeutic approach for treating cancer but the efficiency delivery of genes to desired locations with minimal side effects remains a challenge. Here, we report on the development of magnetic iron oxide (Fe3O4) nanoparticles which the magnetism properties possessed by magnetic Fe3O4 nanoparticles improved the delivery process of nanoparticles to the cancer site by using the external magnetic field influence. Besides that, size of nanoparticles also played a critical role during the transportation process of nucleic acid. Thus, Fe3O4 nanoparticles were prepared using co-precipitation method to study the effects of varied pH of solution towards the final size of nanoparticles. The characterization of all samples were done using FTIR, XRD and FESEM. In this study, the smaller primary particles size of Fe3O4 nanoparticles was produced with increased the solution pH from pH=11.33 to pH=12.15. However, remarkable large size was formed at pH greater than 12.15 due to some reason.
Experimental Demonstration of Extended 5G Digital Fronthaul Over a Partially-Disaggregated WDM/SDM Network

We experimentally demonstrate a 5G digital fronthaul network that relies on multi-adaptive bandwidth/bitrate variable transceivers (BVTs) and an autonomic software-defined networking (SDN) control system for partially-disaggregated wavelength division multiplexing (WDM)/space division multiplexing (SDM). Transmission of 256-QAM 760.32 MHz orthogonal frequency-division multiplexing (OFDM) radio signal is performed, with a total radio transmission capacity of 5.667 Gb/s. Digitized signal samples are carried as a 22.25 Gb/s digitized radio-over-fiber (DRoF) data stream and transmitted over a WDM/SDM infrastructure including 40-wavelength 100-GHz arrayed waveguide gratings (AWGs) and 19-core fiber. The autonomic SDN controller deploys a control loop for the multi-adaptive OFDM-based BVTs that monitors the per-subcarrier signal to noise ratio (SNR) and assigns the optimal constellation based on the actual signal degradation. An error vector magnitude (EVM) below the targeted 2.1% is achieved while setting up connections in less than 5 s.
Vibration Reduction of Flexible Rope-Driven Mobile Robot for Safe Façade Operation

In recent years, cable-driven-parallel robots (CDPRs) have been studied for façade operations. There are various types of CDPRs; however, underconstrained CDPRs are capable of wider operating in façade workspaces than overconstrained CDPRs. Therefore, in this article, a dual ascender robot (DAR) was used for façade operations. Herein, two suggestions for safe façade operations are presented. First, a flexible nylon fiber rope was modeled such that the vibration direction, natural frequency, and damping ratio of the DAR could be converted through a Jacobian matrix and modal decomposition from the rope model. Second, input shaping control was applied to reduce vibrations, based on the vibration model of a DAR using the rope model. Modal decomposition was verified using a verification experiment, and the effect of input shaping was evaluated by comparing the w/input shaping and w/o input shaping experiments. w/input shaping case was shown about 48% reducing robot vibration and about 35% shortening settling time compare with w/o input shaping case.
Financial Market Integration Between Stock Market From North American Free Trade Agreement (NAFTA) Member

Economic recession or crisis could show a higher possibility of financial crisis transmission in an integrated stock market. Integration between financial markets is a channel of spreading the devastating effects of the crisis. The objective of this study is to detect significant interactions among the stock markets of countries that are members of the North American Free Trade Agreement (NAFTA). NAFTA is a regional partnership with members from the United States, Canada and Mexico that are committed to reducing trade and investment barriers between member countries. The methodology of this research with VAR VECM model consists of three stages, the first analysis of the presence impact of the stock market index using the Granger Causality Test. Second, analyze the speed of response of an index to a change / shock in another index using the Impulse Response Function (IRF). The third stage analyzes the impact of changes / shocks from one index to other indices by using Variance Decomposition. From the 5 sets of stock market data for NAFTA countries, the results of the study show that there is only one cointegration. When viewed in the cointegration process of each of the two data series, cointegration occurs between the Nasdaq index with TSE and Nasdaq with MSE. Whereas TSE and MSE did not find any cointegration.
HASH Algorithm of Weighted Probability Model

In this paper, a brand-new hash algorithm is provided. The length of the hash value can be customized. It is theoretically proved that the hash collision limit can be reached. The algorithm can be applied flexibly, and it can be applied to digital signatures, document verification and other fields in the future.
Superconductor Computing for Neural Networks

The superconductor single-flux-quantum (SFQ) logic family has been recognized as a promising solution for the post-Moore era, thanks to the ultrafast and low-power switching characteristics of superconductor devices. Researchers have made tremendous efforts in various aspects, especially in device and circuit design. However, there has been little progress in designing a convincing SFQ-based architectural unit due to a lack of understanding about its potentials and limitations at the architectural level. This article provides the design principles for SFQ-based architectural units with an extremely high-performance neural processing unit (NPU). To achieve our goal, we developed and validated a simulation framework to identify critical architectural bottlenecks in designing a performance-effective SFQ-based NPU. We propose SuperNPU, which outperforms a conventional state-of-the-art NPU by 23 times in terms of computing performance and 1.23 times in power efficiency even with the cooling cost of the 4K environment.
Should human history give us hope?

Rutger Bregman (1988) is an engaged historian and a prolific writer. In the Netherlands he became known nationwide for his socially critical articles and a book, pleading for a basic income. In his latest book, Humankind: a hopeful history he deals with scientists which are too misanthropic. According to Bregman, science has often judged man too harshly which works as a self-fulfilling prophecy. This negativity already started in the Enlightenment, according to Bregman: philosophers like Adam Smith and David Hume believed in the goodness of man, but Adam Smith, particularly, did not want to rely on it in trade and politics. During the industrialization some scientists gradually became more and more pessimistic, especially since the Second World War. Scientists such as Stanley Milgram (with his electroshock experiments), Philip Zimbardo (known from the Stanford prison experiment) and Richard Dawkins (author of The Selfish Gene) have proclaimed that humans are above all selfish, opportunistic and greedy. According to Bregman, this image of man reflects and reinforces our predatory capitalism based on distrust, greed and exploitation. In the end, we get the world which we expect. The solution, according to Bregman, is simple: we must reverse the self-fulfilling prophecy, replace the misanthropic 'Golem effect' with the optimistic 'Pygmalion effect'. History proves time and again that people are capable of incredible good deeds. Evolutionally, we are the product of self-domestication and actually gentle 'puppy' primates, a merry puppy, as Bregman calls us. Most people are good: this is actually the title of the original Dutch version of the book. We are Slurink, P. (2021). Should human history give us hope? Human Ethology, 36, 3-6. https://doi.org/10.22330/he/36/003-006
The Assist Performance Test of Industrial Passive Waist-assistant Exoskeleton on Fatigue during a Repetitive Lifting Task

Low back pain is a serious industrial problem and a common chronic disabling disease that affects the health of many workers, with a steadily rising rate of incapacity due to low back pain and a burden on individuals, families, businesses and society. Therefore, a new type of wearable lifting assist device, called the Industrial Passive Waist-assistant Exoskeleton (IPWE), was developed for workers’ working conditions to reduce the risk of lower back muscle damage during manual handling. The purpose of this study was to evaluate the impact of this IPWE on the muscle activity and oxygen consumption of the lower back in simulated lifting tasks. Meanwhile, local perceived stress, subjective perceived fatigue and system availability of the exoskeleton system were evaluated. The results showed that the IPWE significantly reduced the muscle activity of the thoracic erector spinaes and lumbar erector spinaes. During the 15-minute repetitive lifting task, the electromyographic amplitudes of the thoracic erector spinae TES1, TES2 and the lumbar erector spinae LES1, LES2 decreased by 19.14%, 14.63%, 28.03% and 25.05%, respectively. In addition, the exoskeleton did not cause significant differences in oxygen consumption and subjectively perceived fatigue. But it caused increased local pressure on the thighs and shoulders. Among them, IPWE was considered to have acceptable availability by half of the subjects. However, the obvious contact pressure on certain body parts were the cause of discomfort caused by IPWE.
PAULO FREIRE: O ROUSSEAU DO SÉCULO VINTE: A ESSÊNCIA DE SUAS IDEIAS SOBRE ALFABETIZAÇÃO E LIBERTAÇÃO DO PONTO DE VISTA DE UM INDIANO E A PERSPECTIVA DO TERCEIRO MUNDO

Paulo Freire, como filósofo, associou a alfabetização à libertação e, como pedagogo, apresentou inovações revolucionárias nas técnicas de alfabetização do analfabeto adulto. Em seu método único, uma pessoa analfabeta poderia ser alfabetizada em um período de trinta horas. A evolução da epistemologia freireana foi atribuída às condições de vida no Nordeste brasileiro. Muitas das ideologias de Freire estavam enraizadas na história do Brasil. A colonização do país pelos portugueses e a forma como a população indígena foi submetida ao trabalho escravo e, posteriormente, a importação de milhões de escravos africanos para trabalhar nas plantações - provocaram profundas feridas psicológicas nas relações humanas. Escravidão, a forma mais degradante de relação social e econômica juntamente com a união sexual do senhor com o escravo trouxe uma espécie de sadismo por parte da supremacia branca e certo masoquismo por parte de indígenas e africanos. Mesmo após a abolição da escravidão (1888), o sadismo e o masoquismo continuaram assombrando a sociedade brasileira. As cicatrizes eram bastante visíveis durante o tempo de Freire, razão pela qual ele caracterizou a realidade do Brasil como 'opressora'. Apesar de tanto a humanização quanto a desumanização serem alternativas reais, apenas a primeira pode ser a 'vocação' do povo, e mesmo sendo constantemente negada, é afirmada por essa mesma negação, conjecturou Freire. A história do Brasil nos últimos quinhentos anos tem sido estudada; foi investigado como as várias fases de sua história resultaram na formulação da teoria e na prática de Freire sobre alfabetização e libertação. Por fim, foi explorada a aplicabilidade de sua teoria e pedagogia no campo da educação de adultos em outros países do terceiro mundo, incluindo a Índia.
Testing of the technology of cavitation treatment of sunflower oil sludge to increase the digestibility of feed for calf bulls

The article presents the results of research to assess the effectiveness of the developed technology for processing sunflower oil sludge, using cavitation, to increase the digestibility of feed and metabolism of calf bull. When introduced into the diet of sunflower oil sludge in the native form + 10 % (group II). It was established that the highest indices of digestibility of the majority of nutrients were in cavitated fuse. In particular, fodder enriched with fuse contributed to greater energy consumption and its more productive use. Digestible energy was higher by 7.1 % (P≤0.05) and 9 % (P≤0.05) in groups I and II, respectively. Metabolic energy exceeded the control level by 5.7 and 7.1 MJ. The inclusion of fuse in the compound feed increased nitrogen digestion by 4.5 % (P≤0.05) in group I and by 5.8 % (P≤0.01) in group II. At the same time, higher indicators are achieved when feeding with fuse treated by the cavitation method.
Torque Ripple Suppression Control for PMSMs using Feedforward Compensation and Online Parameter Estimation

This paper presents a control scheme for smooth torque production in permanent-magnet synchronous motor drives. The proposed control scheme consists of two techniques: a feedforward compensation for torque ripple minimization and an online parameter estimation technique for harmonic ﬂuxes. The feedforward compensation is constructed on a position-sensorless vector control system and generates voltage commands to suppress torque ripples. The command calculation process requires the parameters of the harmonic ﬂuxes; therefore, the proposed control scheme includes their estimator and calculates them from detected current information. These techniques are simpler than existing ones and can be implemented on a computational device with a small amount of calculation load. The proposed control scheme is veriﬁed by performing simulations and experiments.