Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECT OF NANOCURCUMIN PARTICLES PREPARED BY TOP-DOWN METHOD ON CCl4- INDUCED HEPATIC FIBROSIS MICE

Curcumin, a hydrophobic polyphenolic compound derived from the rhizome of the herb Curcuma longa, possesses a wide range of biological applications including anti-cancer. Nanocurcumin particles were prepared by top-down method as its can improve hydrophilic and increase bioavailability. As a result, curcumin concentration was yielded up to 10% (w/w), and the particle size was defined less than 1,000 nm in diameter. The particles were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), dynamic laser light scattering (DLS), and X-ray diffraction (XRD). The acute oral toxicity was done with a dose up to 500 mg per kg of body weight and no dead mice were found indicating the nanocurcumin particles are safe for long-term use. The model of hepatic fibrosis mice was induced by intraperitoneal (i.p) injection of 0.8 mL of carbon tetrachloride (CCl4) in olive oil (1:3 v/v) per kg of body weight. Nanocurcumin particles (15 mg/kg of body weight) were orally administered to hepatic fibrosismouse model in 4 weeks to evaluate the therapeutic potential in comparison to other groups. The results indicate that nanocurcumin have significant effects on reducing levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in CCl4-induced hepatic fibrosis mice. Histological examination shows that hepaticfibrotic livers of mice treated with nanocurcumin particles were recovered after 4 weeks. INTRODUCTION: According to the National Nanotechnology Initiative (2006), “Nanotechnology is the understanding and control of matter at dimensions of roughly 1-100 nm 1 ”. However, this definition of nanoparticle size was established for chemistry, physics and electronics; in the fields of nano food and herb research, the particle size of interest is 1–1,000 nm. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.4(12). 4542-48 Article can be accessed online on: www.ijpsr. com DOI link: http://dx.doi. org/10.13040/IJPSR.0975-8232.4(12). 4542-48 Nanotechnology is a multidisciplinary scientific undertaking, involves creation and utilization of materials, devices, or systems on the nanometer scale. Nanoparticles represent a promising drug delivery system of controlled and targeted release. On the other hand, polymeric nanoparticles offer some specific advantages over liposome. For instance, they help to increase the stability of drugs/proteins and possess useful controlled release properties 2 . Nanoparticles are easier to pass through cell membranes in organisms and get interacted rapidly with biological systems 3 .
Surface sterilization and in vitro propagation of Prunus domestica L. cv. Stanley using axillary buds as explants

The aim of the study was to investigate the factors needed for establishing an effective protocol for propagation of Prunus domestica cv. Stanley using axillary buds. Axillary buds were sterilized by using different concentration of sodium hypochlorite and mercuric chloride, and then cultured on Murashige and Skoog media supplemented with 6-benzoylaminopurine (BAP) or kinetin (KIN) (0.5-3.0 mg/l) alone and in combination with indole-3-butyric acid (IBA) (0.1-0.5 mg/l). The shoots were transferred to half strength MS medium supplemented with varying concentrations of IBA or indole-3-acetic acid (IAA) (0.5-3 mg/l) for root growth and development. The highest significant survival value (97%) were recorded when explants disinfected with 2% sodium hypochlorite for 15 minutes and 0.1 % mercuric chloride for 7 minutes. The highest multiplication rate as well as length of axial and lateral shoots was obtained on media with BAP. Very poor multiplication was achieved on media with KIN. Whereas, in many combinations of KIN or BAP with IBA, and particularly in those with BAP and IBA, highest shoot proliferation was achieved. The highest shoot induction was observed on MS media supplemented with 0.5 mg/l BAP in combination with 0.1 mg/l IBA with an average number of 3.08 ± 0.58 shoots per explants and 3.33 ± 0.29 cm average shoot length. The highest rooting was observed on 1.0 mg/l IBA with an average number of 4.25 ± 1.2 roots per shoot and 3.6 ± 0.1 cm average root length. Therefore, these developed protocols are recommended for in vitro regeneration of Prunus domestica L. cv. Stanley.
Design of a Power Efficient D-Flip Flop using AVL Technique

Power optimization is a very crucial issue in low voltage applications. This paper presents a design of D-Flip flop circuit using AVL techniques for low power operation. It reduces the value of total power dissipation of applying the adaptive voltage level at ground (AVLG) technology in which the ground potential is raised and adaptive voltage level of supply (AVLS) in which supply potential is increased. The main aim of the design is to investigate the power dissipation for D-Flip flop for the proposed design style. The simulation results show the there is a significant reduction in power consumption of this proposed cell with the AVL technique. The AVLS technique has less power dissipation 1.13 nwatts compared to AVLG technique 2.25 nwatts. The circuit is designed using H-Spice 130nm technology
Addictions among Rural areas of India: a

Addiction is one of the great evils of our time. It has become a serious problem in India. Young and old alike everywhere are addicted to drugs. It has resulted in increased crime, tension, disease, horror and lack of peace and security. As Per The Available Literature In India Most Addictions Include Use of tobacco both in smoking and chewing form and alcohol of which illegally prepared country liquor alcohol use is a major social as well as health issue. In India among adults, most deaths are from respiratory, vascular, or neoplastic disease or from tuberculosis; the death rates from these disease can be increased by smoking [1]. Smoking is a practice in which substance like tobacco is burned and tasted or Inhaled. Globally, smoking kills more than four million people every year and likely to cause more premature death by 2020 [2]. India ranks third in global tobacco production and consumes almost 50% of its produce domestically. Smoking tobacco exposes the smoker to More than 7000 chemicals of which nearly 250 were proven to be harmful and nearly 69 carcinogenic respectively. Smoking has the potential to affect every part of the body and cause many diseases such as aggravation of asthma and respiratory, cardiac diseases [3].
Handedness in Schizophrenia: Any Familial Difference?

Background: The search for possible endophenotype in schizophrenia research is a focus for many researchers in the field of biological psychiatry. The present study sought to assess the handedness differences in the familial risk of schizophrenia. Methods: The present study elicited information on hand preferences of schizophrenia probands using Annett Hand Preference Questionnaire. The family history approach using Family Interview for Genetic Studies (FIGS) was used to elicit family history information about the relatives of the patients. Data were analyzed to compare handedness and family history of schizophrenia using Chi-square test. Results: The mean age of schizophrenia probands was 31.76 ± 10.40, the prevalence of right-and non-right-handedness in the schizophrenia probands were 95.7% and 4.3%, respectively. Handedness was not significantly associated with family history of schizophrenia (x2 = 2.744, df = 1, p = 0.098). Conclusion: The finding of this study does not support handedness as a possible endophenotype in schizophrenia research. This underscores the need to further search of heritable intermediates that will enhance the search for the genetic basis of the disease.
Low Power CNTFET-Based Ternary Full Adder Cell for Nanoelectronics

In a VLSI circuit, about 70 percent of area occupies by Interconnection. Such a large number of area occupation leads to many limitations of fabricating and applying in binary circuit implementation. Multiple-valued logic is one of the most proper way to improve the ability of value and data transferring in binary systems. Nowadays as small portable devices consuming are largely increased, applying low power approaches are considerably taking into account. In this paper we suggest and evaluate a novel low power ternary full adder cell which is built with CNTFETs (Carbon Nano-Tube Field Effect Transistors). Using beneficial characteristics of CNTFET in our design and implementation notably increased the efficiency of this adder cell. Simulation results using HSPICE are reported to show that the proposed TFA (ternary full adder) consume significantly lower power and impress improvement in term of the power delay product compare to previous work.
Paper on Clustering and Validation Techniques

Clustering is important in data analysis and data mining applications. It is the task of grouping a set of objects so that objects in the same group are more similar to each other than to those in other groups (clusters). The overall goal of the data mining process is to extract information from a large data set and transform it into an understandable form for further use. Clustering can be done by the different no. of algorithms such as hierarchical, partitioning, grid and density based algorithms. Hierarchical clustering is the connectivity based clustering. Partitioning is the centroid based clustering, the value of k-mean is set. Clustering has been applied to serve various purposes like, to gain insight to data distribution, generate hypotheses, to observe the characteristic and find anomalies. The intension of this paper is to provide a categorization of some well known clustering algorithms. It also describes the clustering process and overview of the different clustering methods. The validation of clustering structures is the most difficult and frustrating part of cluster analysis. Validation comparing the results of two clusters and find out the best cluster.
An Advanced approach for Summarization and Timeline Generation of Evolutionary Tweet Streams

: Tweet are being created short text message and shared for both users and data analysts. Twitter which receive over 400 million tweets per day has emerged as an invaluable source of news, blogs, opinions and more. Our proposed work consists three components tweet stream clustering to cluster using tweet cluster algorithm and second tweet cluster vector technique to generate rank summarization using greedy algorithm, therefore requires functionality which significantly differ from traditional summarization. In general, tweet summarization and third to detect and monitors the summary-based and volume based variation to produce timeline automatically from tweet stream. Implementing continuous tweet stream reducing a text document is however not an simple task, since a huge number of tweets are worthless, unrelated and raucous in nature, due to the social nature of tweeting. Further, tweets are strongly correlated with their posted instance and up-to-the minute tweets tend to arrive at a very fast rate. Efficiency—tweet streams are always very big in level, hence the summarization algorithm should be greatly capable; Flexibility— it should provide tweet summaries of random moment durations. Topic evolution—it should routinely detect sub-topic changes and the moments that they happen.
Quality Of Life of Schizophrenics and Depressives In Relation To Gender and Residential Location

An attempt was made to study the subjective quality of life experiences of schizophrenics and depressives in eight major life areas in relation to gender and residential location and also to draw a comparative picture of subjective life experiences of schizophrenics vis-a-vis depressives. The clients approaching for psychiatric care in the outpatient department of the SCB Medical College, in Cuttack, Odisha, and diagnosed as either schizophrenics or depressives by a psychiatrist, were administered the Lehman Quality of Life Interview (QOLI). The sample consisted of 60 schizophrenics and 60 depressives evenly divided across gender (male and female) and residential location (urban and rural). The design was a 2 (schizophrenics and depressives) X 2 (male and female) X 2 (urban and rural) design with 15 subjects per cell. Subjects were individually administered the Lehman QOLI in the presence of one of their family members, who also provided substantial information about the patients. The results of ANOVA performed on the scores in major life areas revealed significant main effect of ‘type of disorder’, while the ‘gender’ influence was not significant in any of the areas. The residential location differences were significant in respect of clients’ experiences of living situation, family and financial support and health. While in all the life areas, the depressives felt ‘most dissatisfied’, the schizophrenics felt either ‘unhappy’ or ‘terrible’ pointing out that life experiences are very hard for schizophrenics as compared to depressives. The influence of gender or residential location was very minimal compared to the type of disorder the client was suffering from. Psychiatric and psychological care to schizophrenics and depressives needs to take into consideration the type of disorder, the residential location of the patients and the life areas severely affected, with minimal emphasis on the gender of the patients.
A 20-as kromoszómát érinto numerikus, illetve strukturális eltérések három eset alapján

Összefoglalás: A szerzôk három eset kapcsán áttekintést nyújtanak a 20-as kromoszómát érintô néhány számbeli és szerkezeti kromoszóma-eltérésrôl, különös tekintettel a prenatalis diagnosztikára, valamint a genetikai tanácsadásra. E jól dokumentált esetek ismertetésével igyekeznek a gyakran elôforduló 20-as trisomia mozaicizmus, az idáig igen ritkán publikált 20-as trisomia, valamint a 20p-deletio klinikai genetikai vonatkozásait összefoglalni.
Two Wavelength Method for Estimation of Drotaverine Hydrochloride and Mefenamic Acid in their Combined Tablet Dosage Form

A new, simple, accurate and sensitive UV-spectrophotometric Two wavelength method has been developed for simultaneous determination of Drotaverine HCL and Mefenamic Acid in combined pharmaceutical dosage form. Two wavelength i.e. 240 nm and 277 nm were selected for estimation of Drotaverine HCL where as wavelength 233 nm and 253 nm was selected for estimation of Mefenamic Acid using Methanol solution as solvent . Drotaverine HCl and Mefenamic Acid shows linearity in the concentration range of 0-30 μg/ml and 0-30 μg/ml respectively. The method was validated statistically.
Student Behaviour Predictions using Social Media Network in Hadoop Framework

: Now a day’s social media provide a range of opportunities for understanding human behaviour through the large aggregate data sets that their operation collects. Data Mining is very useful in the field of education especially when examining students’ learning behaviour in online learning environment. So Student’s casual conversations on social media (Twitter) shed light into their educational experiences like opinions, feelings, and concerns about the learning process. Data from such instrumented environments can provide valuable knowledge to inform student learning. Analysing such data, however, can be challenging. The complexity of students’ experiences reflected from social media content requires human interpretation. However, the growing scale of data demands automatic data analysis techniques. In this paper, we developed a workflow to integrate both qualitative analysis and large-scale data mining techniques. We focused on engineering students’ tweets to understand issues and problems in their educational experiences. We found engineering students encounter problems such as heavy study load, lack of social engagement, negative emotions and sleep deprivation. So we implemented Range classification algorithm to classify tweets reflecting students’ problems. It can inform educational administrators, practitioners and other relevant decision makers to gain further understanding of engineering students’ college experiences .
Melanoma: A Review On Various Segmentation Techniques

— This paper highlights the various segmentation algorithms used in the automated melanoma detection . The application of biomedical image processing for diagnostic purpose is a non invasive technique. In order to identify skin cancer at an early stage without performing unnecessary biopsies, digital images of melanoma skin lesion have been investigated. Different segmentation techniques which aids in the efficient detection of malignant melanoma has reviewed in this paper. Among the implemented algorithms, wavelet network shows better segmentation results for skin cancer images. Automatic border detection is a challenging task in dermoscopic images.
Liposome formulation of soybean phosphatidylcholine extract from argomulyo variety soy to replace the toxicity of injectable phosphatidylcholine solution containing sodium deoxycholate

Subcutaneous injection lipolysis using phosphatidylcholine (PC) and sodium deoxycholate (SD) solution has been used in clinical practice with toxicity concerns of SD, a detergent emulsifier. Liposomal formulation of PCfrom local Indonesian soybean without SD was thought to be a safer alternative for this purpose. The aim of this study was to develop injectable liposome formulations from soybean phosphatidylcholine (SPC) extract from Argomulyo variety soy. In addition, this study was aimed to compare the physical characteristics between the liposomes of SPC extract and the liposomes of purifiedSPC. SPC extract was obtained by extraction-fractionation process from soybean powder. Liposome was prepared using thin film hydration (hand-shaking) method followed by a stepwise extrusion process through decreasing pore size extruder, i.e. 0.45 μm, 0.20 μm, and 0.10 μm. Liposomes were then characterized physically and microscopically.Laser scanning confocal microscopy (LSCM) with quinacrine dye andtransmission electron microscopy (TEM) without quinacrine dye was used for morphological confirmation. The median size of liposomes fromSPC extract containing 26.2% of PC was 48.9 nm with polydispersity index of 0.35. The liposomes were anionic with mean zeta potential of -17.25 mV. Liposomes from purifiedSPC was larger with median size of 68.3 nm and polydispersity index of 0.16;the liposomes were cationic with mean zeta potential of 58.23 mV. Confirmation using TEM showed spherical structures covered with a single layer both from purifiedSPC and SPC extract. Liposomes of SPC extract could satisfyingly be produced using local, Argomulyo variety soy. The liposomes were uniformly small, nanoparticle-sized, unilamellar, and negatively charged. These characteristics are suitable for subcutaneous injection to be used as lipolytic agent to replace the commercial PC plus SD solution.
Correlação entre o perfil lipídico do sêmen de garanhões e a qualidade espermática pós-descongelação

CABRERA, T. CORRELATION BETWEEN THE LIPID PROFILE OF THE SEMEN FROM STALLIONS AND POST-THAWING SPERM QUALITY. Botucatu, 2017 48p, Tese (Doutorado). Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista “Júlio de Mesquita Filho”. The sperm membrane is characterized by a significant amount of lipids related to specific functions such as fusogenicity and permeability required for the sperm to reach and fuse to the oocyte and whose lipid profile differs between species and individuals of the same species. Studies have shown that this lipid composition is directly associated with the maintenance of the plasma integrity and the spermatozoa resistance to freezing since the exposure of this cell to this process modifies the lipid composition and organization of the membrane, thereby reducing longevity and, consequently, the fertilizing capacity of the sperm cell. The presence and quantity of specific lipids, such as phosphatidylcholines, sphingomyelins, seminolipids, plasmalogens and fatty acids with different degrees of saturation, besides cholesterol exert important functions associated to the capacitation, motility, viability and preservation processes of sperm membrane integrity. Thus, a larger study on lipid composition of the semen and its influence on the quality of frozen semen would allow us to find new strategies to improve the resistance of the sperm cell to the cryopreservation process.
Correlations among Motor Function, Quality of Life, and Caregiver Depression Levels in Children with Cerebral Palsy

Korea Purpose: This study aimed to evaluate the relationships among quality of life, caregiver depression levels, and disease severity, especially motor function, in children with cerebral palsy. Methods: Data were collected through questionnaires using survey and interview from 80 caregivers of children with cerebral palsy. The caregivers’ quality of life was measured using medical outcomes study 36-item short form health survey, and level of depression was scored using the beck depression inventory. In addition, children’s motor function was evaluated using gross motor function measure-88 and functional independence measure scores. Results: Among 8 domains of medical outcomes study 36-item short form health survey, “physical functioning,” “physical role function-ing,” “mental health,” and “bodily pain” domains were significantly correlated to “total” percentage scores of gross motor function mea-sure-88. In addition, “mental health” and “bodily pain” domains were correlated to each sub-dimension, including “lying and rolling,” “sitting,” “crawling and kneeling,” “standing,” and “walking, running, and jumping. ” Similarly, the “running” and “jumping” dimensions including motor function measures correlated with “transfer,” “locomotion,” and “motor subtotal” of functional independence measure scores. The beck depression inventory scores were negatively correlated to “lying and rolling,” “sitting,” “crawling and kneeling,” and the “total” percentage scores of gross motor function measure-88. The beck depression inventory scores were negatively correlated to “sphincter control,” “communication,” “social cognition,” “cognitive subtotal,” and “total” functional independence measure scores. Conclusion: It is necessary to consider the quality of life and emotional problems of caregivers of CP children and support them both physically and psychologically with comprehensive
RATIONAL USE OF ANTIBIOTICS IN OSTEOMYELITIS

Osteomyelitis (OM) is a progressive infection of the bone marrow and cortex caused by bacteria or fungi resulting in inflammatory destruction of the bone. The incidence of disease is related to joint replacements, complex surgical interventions and wound infections. Aim was to evaluate the rational use of antibiotics to reduce the further incidence of infection & mortality related to OM.This was a retrospective study carried out in different hospitals of Lahore. A total of 35 patients with the complaint of Osteomyelitis were selected randomly from the Jinnah Hospital, Lahore; Mayo Hospital, Lahore between the period of 7 June 2010 to 28 June 2010.Study method adopted was performa. Through our study we came to know that males are more commonly affected than females. 57.14% patients have compromised health status because host deficiencies are involved in the direct inoculation of micro-organism & spread of infection. Most commonly affected bone by OM is Tibia(51.4%) and Femur(34.28%). S.aureus was most common causative agent of OM in 78.26% of patients.Most commonly prescribed antibiotics for OM are Cephalosporins 57.14%, Fusidic acid and Linezolid 34.28%, Other Penicillins & Fluoroquinolones 20%. We concluded that rational antimicrobial treatment often involves a combination of antibiotics, either given orally or parentally based on results regarding microorganism sensitivity, patient compliance & health status of patients. A minimum of 4-6 weeks of oral or parenteral antimicrobial therapy along with surgery has become a standard therapy for Osteomyelitis.