Miracle-dz/UniFAR-FTUs huggingface dataset:
Security of computer communication

Security of digital computer communications is rising on the list of computer security requirements as the interconnection of computers becomes more commonplace. The reasons for interconnecting computers include improved service, improved reliability, and improved information. However, there are risks in connecting computers. A recent newspaper article reports a story about a woman who was told that she could not make a deposit in her bank account on a certain day from a branch bank. When she asked why, the answer was “because its raining too hard. ” The reply was absolut.ely accurate. When the intensity of the rain exceeded some threshold, the communications between the terminal in . the branch bank and the computer in the central bank became garbled because of wet telephone connections and all interbank operations had to be suspended. The security provided by the techniques described in this paper will do nothing to alleviate this problem. In fact, the techniques cannot solve many of the practical security problems encountered in computer operations. They will provide, however, high levels of security against certain types of real threats, both existing and
Hippocampal Sclerosis: Progress Since Sommer

Hippocampal sclerosis (HS) continues to be the most common pathology identified in patients with refractory temporal lobe epilepsy undergoing surgery. Wilhelm Sommer described this characteristic pattern of neuronal loss over 120 years ago through his post‐mortem studies on patients with epilepsy. Neuropathological post‐mortem studies in the 20th century proceeded to contribute significantly to the understanding of this disease process, with regard to the varying patterns of HS and involvement of adjacent limbic structures. From studies of surgical temporal lobe specimens from the 1950s onwards it was recognized that an early cerebral injury could act as the precipitant for the sclerosis and epilepsy. Modern neuropathological studies have focused on aspects of neuronal injury, loss of specific neuronal groups and cellular reorganization to address mechanisms of epileptogenesis and the enigma of how specific hippocampal neuronal vulnerabilities and glial proliferation are both the effect and the cause of seizures.
A Sequence-Ready Physical Map of Barley Anchored Genetically by Two Million Single-Nucleotide Polymorphisms1[W][OPEN]

A genome-wide physical map of barley was constructed and anchored genetically by a novel method involving whole-genome resequencing of a mapping population. Barley (Hordeum vulgare) is an important cereal crop and a model species for Triticeae genomics. To lay the foundation for hierarchical map-based sequencing, a genome-wide physical map of its large and complex 5.1 billion-bp genome was constructed by high-information content fingerprinting of almost 600,000 bacterial artificial chromosomes representing 14-fold haploid genome coverage. The resultant physical map comprises 9,265 contigs with a cumulative size of 4.9 Gb representing 96% of the physical length of the barley genome. The reliability of the map was verified through extensive genetic marker information and the analysis of topological networks of clone overlaps. A minimum tiling path of 66,772 minimally overlapping clones was defined that will serve as a template for hierarchical clone-by-clone map-based shotgun sequencing. We integrated whole-genome shotgun sequence data from the individuals of two mapping populations with published bacterial artificial chromosome survey sequence information to genetically anchor the physical map. This novel approach in combination with the comprehensive whole-genome shotgun sequence data sets allowed us to independently validate and improve a previously reported physical and genetic framework. The resources developed in this study will underpin fine-mapping and cloning of agronomically important genes and the assembly of a draft genome sequence.
Self-care and quality of life in patients with advanced heart failure: the effect of a supportive educational intervention.

OBJECTIVE The goal of this study was to determine the effects of a supportive educational nursing intervention on self-care abilities, self-care behavior, and quality of life of patients with advanced heart failure. DESIGN The study design was an experimental, random assignment. SETTING The study was located at the University Hospital in Maastricht, The Netherlands. PATIENTS The study included 179 patients (mean age 73 years, 58% men, New York Heart Association classification III and IV) admitted to a university hospital with symptoms of heart failure. OUTCOME MEASURES Outcome measures included self-care abilities (Appraisal of Self-care Agency Scale), self-care behavior (Heart Failure Self-care Behavior Scale), 3 dimensions of quality of life (functional capabilities, symptoms, and psychosocial adjustment to illness), and overall well-being (Cantril's ladder of life). INTERVENTION The intervention patients received systematic education and support by a nurse in the hospital and at home. Control patients received routine care. RESULTS Self-care abilities did not change as a result of the intervention, but the self-care behavior in the intervention group was higher than the self-care behavior in the control group during follow-up. The effect of the supportive educational intervention on quality of life was limited. The 3 dimensions of quality of life improved after hospitalization in both groups, with no differences between intervention and control group as measured at each follow-up measurement. However, there was a trend indicating differences between the 2 groups in decrease in symptom frequency and symptom distress during the 9 months of follow-up. CONCLUSION A supportive educational nursing intervention is effective in improving self-care behavior in patients with advanced (New York Heart Association class III-IV) heart failure; however, a more intensive intervention is needed to show effectiveness in improving quality of life.
Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers.

PURPOSE The purpose of this study was to evaluate whether infusion lines are able to leach plasticizers in substantial amounts and thus be a candidate substance for hepatotoxic effects during long-term total parenteral nutrition (TPN). METHODS TPN solutions, blood products, and selected drugs typical for preterm infants concerning amount, content, and infusion time were perfused through common polyvinylchloride (PVC) infusion lines. Concentration of diethylhexyl-phthalate (DEHP) before and after perfusion was determined by gas chromatography/mass spectrometry. RESULTS Daily quantities of DEHP by 24-hour infusions were Lipid emulsion 20%: 10185.6 microg; aminoacid/glucose-solution: 116.2 microg; midazolaminfusion for sedation: 26.4 microg; fentanyl for sedation: 132.5 microg; propofol for sedation: 6561.0 microg. The amount of DEHP by single doses of blood products (20 mL) were packed red blood cells: 144-608 microg; platelet rich plasma: 928 microg; and fresh frozen plasma: 552-8108 microg. The dose of DEHP for a typical preterm neonate requiring TPN and additional therapy like sedation or blood products is at minimum 10 mg and can easily reach 20 mg/d. CONCLUSION This large amount of DEHP is especially disturbing, because it effects the most vulnerable patients (neonates). Whether there is a relation to TPN-induced hepatobiliary dysfunction remains to be elucidated and is under investigation. With respect to recent literature, a biological effect of these doses must be assumed.
Ferritin Metabolism and the Liver

Ferritin is a ubiquitous water-soluble, iron storage protein present within cells. Its wide distribution in both plant and animal species reflects an essential biologic role. On the one hand, ferritin provides a readily accessible store of the metal essential for the synthesis of hemoglobin and the iron metalloenzymes; on the other hand, ferritin sequesters potentially toxic ionic iron. In addition to that found within mammalian cells, ferritin also occurs in normal mammalian plasma. '*2 Apoferritin consists of a large spherical protein shell with a hollow core within it that is capable of binding up to 4000 atoms of iron (Figs. 1 , 2). 2a The molecular weight o f the apoprotein is approximately 445,000 daltons (d), and it has been shown to conFIG. 2. Diagramatic representation of ferritin molecule showing hydrous ferric oxide core. The arrows indicate the channels through which addition and removal of iron may occur. (Reprinted with permission from Harrison et aI.*)
Childhood acute myeloid leukaemia

Although acute myeloid leukaemia (AML) has long been recognized for its morphological and cytogenetic heterogeneity, recent high‐resolution genomic profiling has demonstrated a complexity even greater than previously imagined. This complexity can be seen in the number and diversity of genetic alterations, epigenetic modifications, and characteristics of the leukaemic stem cells. The broad range of abnormalities across different AML subtypes suggests that improvements in clinical outcome will require the development of targeted therapies for each subtype of disease and the design of novel clinical trials to test these strategies. It is highly unlikely that further gains in long‐term survival rates will be possible by mere intensification of conventional chemotherapy. In this review, we summarize recent studies that provide new insight into the genetics and biology of AML, discuss risk stratification and therapy for this disease, and profile some of the therapeutic agents currently under investigation.
Predictors of Exercise-Induced Mood Change during a 6-Month Exercise and Nutrition Education Program with Obese Women

Obese women (N = 107) enrolled in a YMCA-based exercise and nutrition information program completed rating scales of satisfaction with one's body, self-efficacy related to exercise, physical self-concept, and overall mood, at baseline and at Week 24. Percent of exercise session attendance was also calculated. Multiple regression analysis, with entry of score changes in Body Areas Satisfaction, Exercise Self-efficacy and Physical Self-concept as predictors of change in Total Mood Disturbance, was significant (R2 = .41, p < .001). Exercise session attendance was not significantly related to change in Total Mood Disturbance scores. Present findings supported behavioral explanations of the exercise-mood change relationship in this cross-sectional investigation. Replications with control groups, direct measurement of biochemical markers, and nonselective samples with different characteristics in different contexts with longitudinal designs are required.
Study on Quench Protection Method With Regards to Normal Transition Behavior for HTS Coil

This paper presents the quench detection method with using normal transition behavior for HTS coil. If the HTS coil starts to propagate a normal zone by an initial quench, it will be recovered the superconducting state or runaway thermally. These behaviors were mainly determined by variety parameters like the magnitude of a disturbance, HTS coil size, the structure of winding wire and cooling condition. However, the first step of detection or protection for coils should be started from detecting the presence of a non-recovering normal zone. This paper classifies the initial quench behaviors of HTS wires or coils as a model of 3-type tendencies, and suggests suitable detection techniques for each tendency with using the end-to-end voltage of coil. In additional, this method is able to detect a quench without a decisive criterion used at other quench detection methods. In order to confirm the validity of the method, we used the HTS sample coil wound with YBCO tapes. This paper presents these results and the quench protection properties with fabricated detection method.
Reverse Effect of Aspirin: Is the Prothrombotic Effect after Aspirin Discontinuation Mediated by Cyclooxygenase 2 Inhibition?

Background: While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients. Objectives: We hypothesized that infinitesimal concentrations of aspirin could persist in plasma after its discontinuation, thereby inducing a prothrombotic effect that could be due to a modification in the mechanism of action of aspirin via the cyclooxygenase 1 (COX-1) and COX-2 pathways. Methods and Results: We studied the effects of ultra-low-dose aspirin (ULDA) as well as those of sc-560 and ns-398, specific COX-1 and COX-2 inhibitors, on induced hemorrhagic time and in a model of laser-induced thrombosis in rats. In the laser-induced thrombosis model, ULDA treatment increased the number of emboli and the duration of embolization, thereby confirming its prothrombotic effect described in previous publications. This effect was also observed in rats pretreated with sc-560 but not in those pretreated with ns-398. Conclusions: We demonstrated that ULDA induced a prothrombotic effect in the rats studied. This strongly suggests that a very small amount of aspirin could remain in the patient’s blood after aspirin therapy, leading to cardiovascular complications. This effect may be mediated by the COX-2 pathway.
Basic studies on visible light-curing resin as a denture base. Part 5--Its junctional strength with resin teeth.

In the present study, the authors examined the junctional strength of visible light-curing denture base resin and resin teeth in comparison with that of conventional heat-curing resin. The results obtained were as follows : 1) When visible light-curing resin was used as the resin block on which resin teeth were implanted, the fracture strength for resin teeth having retention holes in the basal planes, was approximately 1.5 times as large as that for teeth with no retention holes. Also, samples in which the resin tooth surface was treated with dichloromethane had a value approximately twice as large.2) When heat-curing resin was used as the resin block on which resin teeth were implanted, employing visible light-curing resin for repair, the fracture strength was small in comparison with the values obtained for specimens described in 1).
Y stenting assisted coiling using a new low profile visible intraluminal support device for wide necked basilar tip aneurysms: a technical report

Many endovascular techniques have been described in recent years for the management of wide necked aneurysms. The Y stent assisted technique has been generally used for coil embolization of wide necked bifurcation aneurysms. This technique was first described for the treatment of basilar tip aneurysms in combination with several different devices, demonstrating encouraging results. We report the results of the first two cases of wide necked basilar tip aneurysms treated with Y stent assisted coil embolization using a new low profile visible intraluminal stent (LVIS Jr; MicroVention, Tustin, California, USA) delivered through a 0.017 inch microcatheter. We also reviewed the literature comparing other endovascular techniques (coiling alone, stent assisted coiling, and Y stent assisted coiling) for wide necked aneurysms. The LVIS Jr device offers a new option for the treatment of these challenging lesions, with clear advantages over currently available intracranial stents. Larger series and long term results are needed to confirm the applicability and durability of this technique/technology.
Visible photonic band gap engineering in silicon nitride waveguides

We demonstrate experimentally the tuning of complete photonic band gaps in patterned silicon nitride waveguides. Transmission measurements were performed using an ultrabroadband high-brightness white light laser continuum, extracting extinction ratios as low as 10–4 in the gap regions. Angle-resolved measurements show the perfect alignment of the gap around the -J direction. © 2000 American Institute of Physics. [S0003-6951(00)02008-8]
A Theory of Liquidity in Residential Real Estate Markets

Abstract A “hot” real estate market is one where prices are rising, average selling times are short, and the volume of transactions is higher than the norm. “Cold” markets have the opposite characteristics: prices are falling, liquidity is poor, and volume is low. This paper provides a theory to match these observed correlations. I show that liquidity can be good while prices are high because the opportunity cost of failing to complete a transaction is high for both buyers and sellers. I also show how state-varying liquidity depends on the absence of smoothly functioning rental markets.
Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis

Protein O-GlcNAcylation regulates cell division. A Mitotic Balance of O-GlcNAcylation and Phosphorylation The posttranslational modification of proteins by the attachment of O-linked β-N-acetylglucosamine (O-GlcNAc) adds an additional layer of regulation to various cellular processes, including cell division. Noting that overexpression of the single enzyme that performs this modification, O-GlcNAc transferase (OGT), causes polyploidy and aberrant spindle formation in cultured cells, Wang et al. performed a global analysis of O-GlcNAcylation and phosphorylation in mitotic cells. They found that in cells forced to overexpress OGT, activation of the cyclin-dependent kinase 1, a master mitotic regulator, was suppressed and the abundance of components of the chromosomal passenger complex was reduced. They identified hundreds of O-GlcNAcylation sites, many of which were located either at the same residue as a potential phosphorylation site or within phosphorylation consensus motifs. Thus, both phosphorylation and O-GlcNAcylation appear to serve as interconnected regulatory events in mitosis. Like phosphorylation, the addition of O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a ubiquitous, reversible process that modifies serine and threonine residues on nuclear and cytoplasmic proteins. Overexpression of the enzyme that adds O-GlcNAc to target proteins, O-GlcNAc transferase (OGT), perturbs cytokinesis and promotes polyploidy, but the molecular targets of OGT that are important for its cell cycle functions are unknown. Here, we identify 141 previously unknown O-GlcNAc sites on proteins that function in spindle assembly and cytokinesis. Many of these O-GlcNAcylation sites are either identical to known phosphorylation sites or in close proximity to them. Furthermore, we found that O-GlcNAcylation altered the phosphorylation of key proteins associated with the mitotic spindle and midbody. Forced overexpression of OGT increased the inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1) and reduced the phosphorylation of CDK1 target proteins. The increased phosphorylation of CDK1 is explained by increased activation of its upstream kinase, MYT1, and by a concomitant reduction in the transcript for the CDK1 phosphatase, CDC25C. OGT overexpression also caused a reduction in both messenger RNA expression and protein abundance of Polo-like kinase 1, which is upstream of both MYT1 and CDC25C. The data not only illustrate the crosstalk between O-GlcNAcylation and phosphorylation of proteins that are regulators of crucial signaling pathways but also uncover a mechanism for the role of O-GlcNAcylation in regulation of cell division.
Performance evaluation of LDPC codes in the presence of colored noise

The class of low density parity check (LDPC) codes includes the most powerful capacity-approaching codes reported to date. As a result, LDPC codes have been considered for application in new communication standards such as 10GBASE-T Ethernet. However, the successful use of LDPC codes for such applications requires a better understanding of the effects of signal impairments on their error correction capabilities. In this paper, the performance of various LDPC codes in the presence of additive colored Gaussian noise (ACGN) is evaluated and compared with the effects of conventional additive white Gaussian noise (AWGN). The simulation results provide insight into the performance of LDPC codes in real systems in which the noise components can indeed be correlated. In particular, our results show that at the same signal-to-noise ratio (SNR), ACGN is more detrimental to the bit error rate (BER) performance than AWGN.
Comparative Evaluation of Monistat and Mycostatin in the Treatment of Vulvovaginal Candidiasis

Monistat Cream® (5.0 g cream equivalent to 0.1 g miconazole nitrate) and Mycostatin Tablets ® (100,000 units nystatin) were compared in the treatment of 116 pregnant and nonpregnant patients with vulvovaginal candidiasis. Of the 56 patients treated with Monistat, 91.1% (51 patients) were cured. Of the 60 patients treated with Mycostatin, 76.6% (46 patients) were cured. This difference in cure rate was statistically significant (0.05). In the pregnant group, all 23 patients (100%) treated with Monistat and 19 of 23 patients (82.6%) treated with Mycostatin were cured. In the nonpregnant group, 28 of 33 patients (84.8%) treated with Monistat and 27 of 37 patients (73%) treated with Mycostatin were cured. Within the nonpregnant group. Monistat cured 14 of 17 oral contraceptive users (82.4%); Mycostatin cured 12 of 19 (63.2%). Side effects were minimal and comparable in the two treatment groups. One patient on Mycostatin had to discontinue therapy because of drug-related side effects. This study demonstrated the superior therapeutic efficacy of Monistat cream when evaluated with Mycostatin in a comparative study.
Spermine induces maturation of the immature intestinal immune system in neonatal mice.

BACKGROUND In mice, immunological adaptation of the gut to microbial and nutritional antigens occurs at weaning in parallel with biochemical and morphological maturation. Because oral administration of spermine to neonatal rats has been shown to induce biochemical and morphological maturation, we investigated whether spermine also affects maturation of the mucosal immune system. METHODS Swiss mice 7, 12, and 27 days old were given spermine orally (0.5 mumol/g body weight) during 3 days. Intestinal length was measured, and lactase and sucrase activities were determined. The phenotype of intraepithelial and lamina propria lymphocytes was assessed by FACS analysis using markers for CD3, TCR alpha beta, TCR gamma delta, CD4, CD8 alpha, CD8 beta, CD5, CD18, CD54, and CD49d. RESULTS Similar to what occurs during natural development, spermine treatment of neonatal mice increased intestinal length, decreased lactase activity, and increased sucrase activity. The percentage of intraepithelial lymphocytes expressing TCR alpha beta, CD4, CD5, and CD54, as well as the levels of expression of these antigens, increased after spermine treatment on day 12, similarly to natural maturation. The increase in expression of CD3, TCR gamma delta, CD18, and CD49d did not reach statistical significance. No effect was observed on CD8 expression. The phenotype of lamina propria lymphocytes was not affected. Spermine administration to 7- and 27-day-old mice had no effect on the phenotype of either intraepithelial or lamina propria lymphocytes. CONCLUSIONS Oral spermine administration to neonatal mice induced, in parallel with biochemical maturation, precocious maturation of the murine intestinal immune system and particularly affected differentiation of the intraepithelial lymphocyte population.