Miracle-dz/UniFAR-FTUs huggingface dataset:
Endplate Deformation Due to Open and Strutted Intervertebral Devices

ABSTRACT Background: There is an absence of work on vertebral endplate response to peripheral loading following disc removal and interbody placement. Endplate deflection into the interbody space may impart beneficial strain on the developing fusion mass, influencing bone formation and remodeling. The aim of this study was to verify endplate deformation due to peripheral loading using a custom transducer and to investigate whether endplate motion is inhibited by implant design. Methods: A total of 14 porcine (L4, L5) vertebrae were assigned to open or strutted implant designs. A custom transducer was placed on the endplate while 500 N was applied to the implant at 1 Hz for 500 cycles. Endplate motion was acquired for each time point and averaged among specimens of the same design. The rates and magnitudes of endplate deformation were compared between implant designs using unpaired t tests. Results: Peripheral loading of both implant designs resulted in endplate deflection into the interbody space. The open implant design demonstrated an increased rate and magnitude of endplate deformation when compared with strutted implants. Conclusion: Interbody cage design directly influences the dynamic motion of the vertebral endplate during cyclic loading. A larger, faster deflection of the endplate could increase the strain rate, duration, and magnitude on the developing interbody fusion mass. These parameters of dynamic strain have been correlated with increased bone formation and remodeling. Clinical Relevance: Unimpeded endplate deformation in an open cage design could impart a strain pattern on the developing fusion mass that increases bone formation and remodeling, ultimately leading to a faster and stronger fusion.
Development of new functional fermented product: mulberry-whey beverage

This study was conducted to produce and evaluate probiotic whey beverage during cold storage for 21 days. Five mixes of probiotic drinks were formulated for sweet whey (SW) and black mulberry (BM) juice. Physiochemical and microbiological properties as well as organoleptic evaluation were determined during cold storage at 4±1°C. The obtained results indicated that acidity of beverage treatments was gradually increased during cold storage. Meanwhile, the pH values and total phenolic contents were decreased gradually during cold storage. On the other hand, the antioxidant activity was increased by increasing the percentage of black mulberry juice; however, it was decreased during cold storage. Results clearly indicated that the viability of L. rhamnosus GG & Bifidobacterium animalis ssp. lactis Bb-12 remained high up to 14 days then started to decline. Sensory properties of all samples were accepted while SWBM3 (25% whey with 75% BM juice) gained the highest organoleptic scores. Our results showed a high potential to produce and develop a new functional fermented whey product.
Selection Mechanism of Micro-Services Orchestration Vs. Choreography

Web services is a special case of a service-oriented architecture (SOA), which is, basically, a representation of web application‘s functionality. Web service is more of a generalized concept that implies whole functionality as a whole but Microservice handles only the single specific task. MSA is emerging as an excellent architecture style enabling the division of large and complex applications into micro-scale yet many services, each runs in its own process, has its own APIs, and communicates with one another using lightweight mechanisms such as HTTP. Microservices are built around business capabilities, loosely coupled and highly cohesive, horizontally scalable, independently deployable, technology-agnostic, etc. On the other side for the business dynamic requirement these microservices need to be composed for the realization of enterprise-scale, and business-critical applications. Service composition is combining various services together to provide the solution for the user dynamic queries. There are two methods for the microservice composition i.e. orchestration and choreography. In this paper,a health case study is performed for the selection mechanism of orchestration method and choreography method in various situation.
Improving Metrics to Rank the Research Performance

Citations are increasingly used to consider research performance. Subsequently, the mathematical and statistical approach by developing metrics are applied to ease the performance measurement. However, almost all the existing metrics only calculate the quantity, not the quality of the citation. This approach is considered unfair. Hence, this study aims to explore the other variables influencing the quality of the research performance ranking. This paper conducted a literature survey finding the citation patterns, which is assumed fairer. Next, the patterns of the citation time window, in-text citation, and citation exclusivity to improve the metrics are suggested. This paper discussed the opportunities and the challenges in combining those patterns in one metric, especially for measuring the research performance in Indonesia.
The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of the Postsynaptic Compartment of C-Type Cholinergic Afferent Synapses on Motoneurons

C-bouton-type cholinergic afferents exert an important function in controlling motoneuron (MN) excitability. During the immunocytochemical analysis of the role of c-Jun in MNs with a monoclonal (clone Y172) antibody against phospho (p)-c-Jun (serine [Ser]63), unexpected labeling was identified in the cell body cytoplasm. As predicted for c-Jun in adult spinal cord, very few, if any MNs exhibited nuclear immunoreactivity with the Y172 antibody; conversely, virtually all MNs displayed strong Y172 immunostaining in cytoplasmic structures scattered throughout the soma and proximal dendrites. The majority of these cytoplasmic Y172-positive profiles was closely associated with VAChT-positive C-boutons, but not with other types of nerve afferents contacting MNs. Ultrastructural analysis revealed that cytoplasmic Y172 immunostaining was selectively located at the subsurface cistern (SSC) of C-boutons and also in the inner areas of the endoplasmic reticulum (ER). We also described changes in cytoplasmic Y172 immunoreactivity in injured and degenerating MNs. Moreover, we noticed that MNs from NRG1 type III-overexpressing transgenic mice, which show abnormally expanded SSCs, exhibited an increase in the density and size of peripherally located Y172-positive profiles. A similar immunocytochemical pattern to that of the Y172 antibody in MNs was found with a polyclonal antibody against p-c-Jun (Ser63) but not with another polyclonal antibody that recognizes c-Jun phosphorylated at a different site. No differential band patterns were found by western blotting with any of the antibodies against c-Jun or p-c-Jun used in our study. In cultured MNs, Y172-positive oval profiles were distributed in the cell body and proximal dendrites. The in vitro lentiviral-based knockdown of c-Jun resulted in a dramatic decrease in nuclear Y172 immunostaining in MNs without any reduction in the density of cytoplasmic Y172-positive profiles, suggesting that the synaptic antigen recognized by the antibody corresponds to a C-bouton-specific protein other than p-c-Jun. Our results lay the foundation for further studies aimed at identifying this protein and determining its role in this particular type of synapse.
Manipulation of the Innate Immune Response by Varicella Zoster Virus

Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles (herpes zoster). VZV and other members of the herpesvirus family are distinguished by their ability to establish a latent infection, with the potential to reactivate and spread virus to other susceptible individuals. This lifelong relationship continually subjects VZV to the host immune system and as such VZV has evolved a plethora of strategies to evade and manipulate the immune response. This review will focus on our current understanding of the innate anti-viral control mechanisms faced by VZV. We will also discuss the diverse array of strategies employed by VZV to regulate these innate immune responses and highlight new knowledge on the interactions between VZV and human innate immune cells.
Effects of prolonged flooding on the cycling of dissolved inorganic carbon in Plinthosols

Cultivation of flooded rice has developed in wetlands of the Cerrado Biome as a result of the expansion of the Brazilian agricultural frontier. Changes in soil moisture content due to agricultural practices associated with flood irrigation may induce geochemical transformations in the soil. The present study aimed at investigating the effect of flood irrigation on inorganic carbon cycling through the determination of dissolved inorganic carbon (DIC) concentrations. Incubation experiments under anoxic and reducing conditions were carried out in laboratory with samples of horizons A, AB, Bf1 and Bf2 of Plinthosols profiles from areas under 20 and 30 year of flood irrigation and natural area of the Irrigation Project Luiz Alves do Araguaia, GO, Brazil. Soil samples under flooding were incubated for 1, 7, 15, 30, 60 and 120 days to simulate the effect of prolonged flooding and after incubation the liquid fraction was analyzed for DIC. Higher concentrations of DIC were found in the A horizon (up to 37.2 mg/L) from soil profiles under cultivation, which may be associated with liming or desorption processes of carbon species. DIC correlated with soil electrical conductivity and Eh. It is concluded that solubilization of inorganic carbon is favored by flood irrigation, especially in Plinthosols that have received liming, as well as by the reducing state of the soil and higher concentrations of ions in solution.
EFFECTS OF RED GRAPE , WILD GRAPE AND BLACK RASPBERRY WINES ON GROUND PORK DURING REFRIGERATED STORAGE

The effects of red grape, wild grape and black raspberry wines on the quality of ground pork during a 15 days refrigerated storage period were investigated. The levels of phenolic compounds were the highest in black raspberry wine (P<0.05). In contrast, the antioxidant capacities according to ferric reducing antioxidant potential (FRAP) and trolox equivalent antioxidant capacity (TEAC) were not significantly different among the wines (P>0.05). The addition of 5% and 10% wine influenced the quality of ground pork by decreasing pH, inhibiting the progression of lipid oxidation and the formation of total volatile basic nitrogen (TVB-N), and stabilizing the red colour of the ground pork compared to control samples to which no wine was added. In ground pork, addition of red grape wine led to lower concentrations of thiobarbituric acid reactive substances (TBARS, 0.19–0.39 mg kg–1) and TVB-N values (69.1–119.9 mg kg–1) than wild grape (0.16–0.43 mg kg–1 and 72.0–194.1 mg kg–1, respectively) or black raspberry wine (0.33–0.58 mg kg–1 and 81.7–225.4 mg kg–1, respectively) up to 10 days of storage. Results from the present study suggested that the quality of ground pork was affected by wine type and storage period. These effects could be due to phenolic compounds as well as other chemical components of the wines.
Large Scale Palm Tree Detection in High Resolution Satellite Images Using U-Net

Oil and coconut palm trees are important crops in many tropical countries, which are either planted as plantations or scattered in the landscape. Monitoring in terms of counting provides useful information for various stakeholders. Most of the existing monitoring methods are based on spectral profiles or simple neural networks and either fall short in terms of accuracy or speed. We use a neural network of the U-Net type in order to detect oil and coconut palms on very high resolution satellite images. The method is applied to two different study areas: (1) large monoculture oil palm plantations in Jambi, Indonesia, and (2) coconut palms in the Bengaluru Metropolitan Region in India. The results show that the proposed method reaches a performance comparable to state of the art approaches, while being about one order of magnitude faster. We reach a maximum throughput of 235 ha/s with a spatial image resolution of 40 cm. The proposed method proves to be reliable even under difficult conditions, such as shadows or urban areas, and can easily be transferred from one region to another. The method detected palms with accuracies between 89% and 92%.
Chlamydia in birds - occurrence, new species and zoonotic potential – a review

Abstract Chlamydiales, one of the oldest bacterial orders in evolutionary terms, are widespread among animals. Blinding trachoma, a disease caused by Chlamydia trachomatis, was already known in ancient times, whereas modern reports on psittacosis date from 1879. Though these pathogens have long been known and lead to serious health problems both in human and animals, data on Chlamydiales biology has been limited. It is due to their intracellular life style and complex developmental cycle. New molecular biological methods have been recently developed expanding the possibilities of chlamydial research and diagnosis. This paper reviews data concerning avian chlamydiosis, its aetiological agent C. psittaci, newly proposed species isolated from birds, namely C. ibidis sp. nov., C. avium sp. nov., and C. gallinacea sp. nov., and their zoonotic potential.
A Novel AdaBoost and CNN Based for Vehicle Classification

Real time vehicle classification is an important issue in Intelligent Transport Systems (ITS). In this paper, we propose a novel model to classify five distinct groups of vehicle images from actual life, based on AdaBoost algorithm and deep convolutional neural networks (CNNs). The experimental results demonstrate that the proposed model attains the highest classification accuracy of 99.50% on the test dataset, while it takes only 28 ms to identify a vehicle image. This performance significantly outperforms the traditional algorithms, such as SIFT-SVM, HOG-SVM and SURF-SVM. Moreover, the proposed deep CNN-based feature extractor has less parameters, thereby occupies much smaller storage resources as compared with the state-of-the-art CNN models. The high prediction accuracy and low storage cost confirm the effectiveness of our proposed model for vehicle classification in real time. INDEX TERMS Real time, Vehicle classification, CNN, AdaBoost, SVM.
Comparison of three therapeutic regimens for genotype‐3 hepatitis C virus infection in a large real‐life multicentre cohort

In the direct‐acting antiviral era, treatment of genotype‐3 HCV (HCV‐GT3) is still challenging. Real‐life comparisons between recommended regimens, sofosbuvir (SOF)+daclatasvir (DAC), SOF/velpatasvir (VEL), glecaprevir/pibrentasvir (GLE/PIB), are scarce. We aimed at filling this data gap.
Exogenous Applications of Moringa Leaf Extract and Cytokinins Improve Plant Growth, Yield, and Fruit Quality of Cherry Tomato

Growth-promoting properties of moringa (Moringa oleifera) leaves were investigated for potential use in crop production by comparing the efficacy of bimonthly foliar and root applications of a moringa leaf extract [MLE (3.3% w/v)] with the cytokinins 6-benzyladenine (6-BA) and trans-zeatin (t-Z), each at 25mg L, to increase plant growth, flowering, yield, fruit size, and fruit quality of ‘Super Sweet 100’ cherry tomato (Solanum lycopersicum). Foliar-applied t-Z and root-appliedMLE increased canopy biomass (P £ 0.01) and rootand foliar-applied MLE increased lateral vegetative shoot number (P £ 0.001) and plant height (P £ 0.001) relative to untreated control plants. Only foliar-applied MLE increased floral shoot number compared with untreated control plants (P £ 0.001). Plants in all treatments, except root-applied 6-BA, produced more flowers than untreated control plants (P £ 0.001). Plants receiving root-applied t-Z produced the greatest number of flowers followed by plants receiving root-applied MLE. Cherry tomato plants treated with root-applied t-Z or MLE produced the greatest number of fruit per plant and significantly more than untreated control plants (P £ 0.001). Foliarapplied 6-BA and MLE and root-applied t-Z and MLE increased yield as grams of fruit per plant compared with the untreated control (P £ 0.01). Foliarand rootapplied MLE increased fruit concentrations of soluble sugars (P £ 0.001), protein (P £ 0.001), antioxidants (P £ 0.001), and lycopene (P £ 0.001) compared with fruit from untreated control plants. Foliarand/or root-applied MLE resulted in the greatest leaf concentrations of protein (P £ 0.01), proline (P £ 0.01), arginine (P £ 0.01), and total antioxidants (P £ 0.05), which were all significantly greater than the concentrations in leaves from untreated control plants. The results of this single experiment provide evidence suggesting that MLE warrants further research as an inexpensive growth promoter for enhancing tomato plant biomass, yield, and fruit quality, especially in organic crop production, which prohibits the use of many commercial synthetic plant growth regulators.
Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition

Melanotan II (MTII), a synthetic analogue of the alpha-melanocyte stimulating hormone (α-MSH), has been applied for skin tanning in humans. However, the carcinogenic consequence of topical MTII has been equivocal. This study aims to delineate the anti-neoplastic efficacy and mechanism of MTII using the B16-F10 melanoma model in vitro and in vivo. It was found that, despite a lack of influence on proliferation, MTII potently inhibited the migration, invasion, and colony-forming capability of melanoma cells. Moreover, topical MTII application significantly attenuated the tumor progression in mice bearing established melanoma. Histological analysis revealed that MTII therapy induced apoptosis while inhibiting the proliferation and neovaluarization in melanoma tissues. By immunoblot and immunohistochemical analysis, it was found that MTII dose-dependently increased the phosphatase and tensin homolog (PTEN) protein level while reducing PTEN phosphorylation, which resulted in the inhibition of AKT/nuclear factor kappa B (NFκB) signaling. Consistently, MTII treatment inhibited cyclooxygenase II (COX-2) expression and prostaglandin E2 (PGE2) production in melanoma cells. Finally, studies of antibody neutralization suggest that the melanocortin 1 receptor (MC1R) plays a critical role in MTII-induced PTEN upregulation and melanoma suppression. Together, these results indicate that MTII elicits PTEN upregulation via MC1R, thereby suppressing melanoma progression through downregulating COX-2/PGE2 signaling. Hence, topical MTII therapy may facilitate a novel therapeutic strategy against melanoma.
Preschool Quality Effects on Learning Behavior and Later Achievement in Germany: Moderation by Socioeconomic Status.

This study investigates whether children's preschool experiences are associated with later achievement via enhanced learning behaviors using data from a German longitudinal study following children (N = 554) from age 3 in preschool to age 8 in second grade. There were two main findings. First, results suggest that more positive learning behaviors at school entry mediate effects of teacher-child interactions in preschool on second-grade achievement. Second, these effects varied by parental socioeconomic status (SES) indicating that low-SES children benefited the most. The findings highlight the role of preschool classroom environments in shaping the school readiness of children with socioeconomic risk factors.
Stationary reflection and the club filter

Suppose that is a regular uncountable cardinal. It has been known that the club filter on P! 1 can be presaturated. In this paper we extend the result to the case of P , where is a regular uncountable cardinal . This involves suitably weakening the notion of presaturation. A new reflection principle for stationary sets in P plays a key role.
Distinct TDP-43 aggregate features and toxicity stratify FTD patients

Laferrière Florent, Maniecka Zuzanna, Pérez-Berlanga Manuela, Hruska-Plochan Marian, 2 Gilhespy Larissa, Hock Eva-Maria, Wagner Ulrich, Afroz Tariq, Boersema Paul J., Gery 3 Barmettler, Foti Sandrine C. , Asi Yasmine T. , Isaacs Adrian M. , Al-Amoudi Ashraf, Lewis 4 Amanda, Stahlberg Henning, Ravits John, De Giorgi Francesca, Ichas François, Bezard 5 Erwan, Picotti Paola, Lashley Tammaryn, Polymenidou Magdalini 6 7 Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, 8 Switzerland 9 Department of Pathology and Molecular Pathology, University Hospital Zurich, CH-8091 Zurich, 10 Switzerland 11 Institute of Biochemistry, Department of Biology, ETH Zurich (ETHZ), CH-8093 Zurich, Switzerland 12 Center for Microscopy and Image Analysis, University of Zurich, CH-8057 Zurich, Switzerland 13 Queen Square Brain Bank for Neurological diseases, Department of Movement Disorders, UCL 14 Institute of Neurology, London, WC1N 1PJ, UK 15 Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, 16 WC1N 3BG, UK 17 UK Dementia Research Institute at UCL, UCL Institute of Neurology, Queen Square, London, WC1N 18 3BG, UK 19 Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel, CH-4058 20 Basel, Switzerland 21 Department of Neuroscience, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 22 92093-0624, USA 23 INSERM U1084, Laboratoire des Neurosciences Expérimentales et Cliniques, Université de 24 Poitiers, 86073 Poitiers, France 25 Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, 33076 Bordeaux, 26 France 27 CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076, Bordeaux, France 28 29 *These authors contributed equally to this work 30 31
DoggyVision: Examining how dogs (Canis familiaris) interact with media using a dog-driven proximity tracker device.

With screen technology becoming ubiquitously embedded into our homes, these screens are often in places where they can be viewed by domestic dogs (Canis familiaris); however, there is a lack of research showing to what extent, and for how long, dogs attend to media on screens. One pressing question is to understand if a dog, given the opportunity, would or could control its own viewing. This paper describes a prototype system (DoggyVision) that gives control to a dog in regard to the turning on and off of a TV screen in order to study activation with screen media in home settings. The system is used with two dogs to explore the interaction modalities between machine and dog. DoggyVision is shown to be non-invasive for the dog and easy to use in the home. Recordings show that dogs did attend to the screen but did not appear, in this study, to change their activation behaviors around the TV screen between being in no control (week 1), and in some control (week 2), of the TV media presentation. The study builds on ‘dog-centered’ methods to examine a dog’s behavior non-invasively demonstrating that useful data can be yielded from dog-driven devices within the home. For the Animal Computer Interaction community, this is the first system that allows the dog to trigger the activation of the device as the system records the activation automatically.
Resuscitating the Co-Fractional Model of Granger

We show that the model for fractional cointegration proposed by Granger (1986) allows for a representation of the solution that demonstrates the fractional and co-fractional properties. Moreover, we show that the stability of the system can be studied by means of the argument principle inherited from complex analysis. As opposed to the FCVARd,b specification of Johansen (2008b), the model is identified for any combination of number of lags and cointegration rank, while being able to generate polynomial co-fractionality. Finally, we characterize the set of recursions to obtain the impulse response functions and we derive the asymptotic theory for the maximum likelihood estimator of the coefficients.