Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnóstico de la complejidad económica del estado de Hidalgo: de las capacidades a las oportunidades

El objetivo del presente trabajo es examinar las oportunidades de diversificacion productiva y de emprendimiento que derivan de las capacidades existentes y potenciales con las que cuenta especificamente el estado de Hidalgo. Para ello, se desarrollo un estudio empirico haciendo uso del Metodo de Reflexiones (MR) y la asignacion de ponderadores, con base en las variables de la Teoria de Complejidad Economica propuestas por Hidalgo & Hausmann (2009) y recopiladas del Atlas de Complejidad (2018). A partir de las operaciones algebraicas, se halla en un primer momento que el estado de Hidalgo se encuentra actualmente ubicado en el cuadrante que refleja: “mayor diversificacion promedio con mayor ubicuidad promedio”. En un segundo momento, la estrategia balanceada de ponderacion, logra generar un ranking de oportunidades que puede ser util para argumentar modificaciones en materia de politica industrial y tambien para orientar y validar proyectos productivos de emprendedores, empresarios e inversionistas en la region. Una limitacion del trabajo es que se basa solo en datos provenientes de la economia formal-industrial y su originalidad radica en que no existen estudios previos en el contexto analizado.
Variational approach to quantum statistical mechanics of nonlinear systems with application to sine-Gordon chains.

The path-integral method is used for determination of the quantum corrections to the free energy of nonlinear systems. All quantum effects of the harmonic part of the potential are considered and a variational principle is used to account for the quantum corrections due to the anharmonic part. Correct renormalized frequencies are obtained at any temperature and an effective potential to be inserted in the configurational integral is found. A new general expression for the partition function at any temperature in the low-coupling limit is obtained.
Acetylcholine‐induced initiation of thymic lymphoblast DNA synthesis and proliferation

Low (5 × 10−9 M to 10−7 M) acetylcholine concentrations cause a calcium‐independent stimulation of the initiation of DNA synthesis and proliferation of lymphoblasts which are part of rat thymocyte populations suspended in vitro. A much higher (5 × 10−5 M) acetylcholine concentration also stimulates lymphoblast DNA synthesis and proliferation, but this action is calcium‐dependent. This proliferogenic response to acetylcholine is however not clearly mediated by either cyclic GMP or cyclic AMP.
Stress-Dependent Nucleolin Mobilization Mediated by p53-Nucleolin Complex Formation

ABSTRACT We recently discovered that heat shock causes nucleolin to relocalize from the nucleolus to the nucleoplasm, whereupon it binds replication protein A and inhibits DNA replication initiation. We report that nucleolin mobilization also occurs following exposure to ionizing radiation (IR) and treatment with camptothecin. Mobilization was selective in that another nucleolar marker, upstream binding factor, did not relocalize in response to IR. Nucleolin relocalization was dependent on p53 and stress, the latter initially stimulating nucleolin-p53 complex formation. Nucleolin relocalization and complex formation in vivo were independent of p53 transactivation but required the p53 C-terminal regulatory domain. Nucleolin and p53 also interact directly in vitro, with a similar requirement for p53 domains. These data indicate a novel p53-dependent mechanism in which cell stress mobilizes nucleolin for transient replication inhibition and DNA repair.
Empowering Chord DHT overlays

In peer to peer networks, the overlay topology connecting peers is an important component in addition to peer and data organization and search. In fact, topological characteristics have an important impact on the efficiency of search on such networks. In this paper, we address this issue for Chord based P2P systems. Based on the Barabasi Albert (BA) model, we propose to extend the topology of Chord to a scale free graph DHT, named PL-Chord, to provide a non hierarchical super-peer based lookup algorithm with an efficient search support. Through several simulation experiments, we found that PL-DHT could construct an overlay network that extends the search region and provides higher reachability at a very little additional cost.
Comparative study of gonococcal susceptibility to penicillin in the United States, 1955-1969.

The incidence of gonorrhea continues to rise at an alarming rate. In 1969, the increase was about 13 96, and an estimated minimum of 1,680,000 cases of the disease will occur in the United States in 1970. Thus, gonorrhea continues to be the number one reported bacterial infection in adults. Although the Public Health Service recommends penicillin as the antibiotic of choice in the treatment of this disease, experts throughout the world generally agree that resistance of Neisseria gonorrhoeae to penicillin has developed and is continuing to develop. In 1954, 11 years after the advent of penicillin in the treatment of gonorrhea, in-vitro studies by Love and Finland [1] demonstrated that all of the 106 cultures of gonococci tested were inhibited by 0.06 units/ml or less of penicillin. Two years later, Thayer et al. [2] reported that 22 96 of the gonococcal isolates tested required 0.2 units/ml of penicillin for complete inhibition. Reyn [3] in 1963, after studying susceptibility of the gonococcus to antibiotics in Denmark, stated that 56 96 of the routine cultures were less sensitive to penicillin than those isolated in 1944.
Propagación del oleaje y asimilación de datos satelitales en un modelo espectral de tercera generación

En la prediccion del oleaje en el mar Caribe, dos mejoras pueden aumentar la precision del modelo: el perfeccionamiento del esquema numerico de transporte del espectro de olas y la asimilacion adecuada de los datos provenientes de las plataformas satelitales. La primera mejora minimiza el error de propagacion de olas de viento a lo largo del fetch y aumenta la exactitud de calculo de olas de mar de fondo (swell). En el trabajo se analizan varios esquemas numericos, tales como Lax-Vendroff, FCT, TVD, “upward” de primer orden de aproximacion y un esquema no central de tercer orden. A pesar de que los esquemas positivos de tipo TVD conservan mejor la forma inicial de las perturbaciones, la mayor exactitud de conservacion integral del espectro fue encontrada con el esquema de tercer orden. Luego de la implementacion de este algoritmo mejorado, se propone una metodologia no tradicional de asimilacion de datos del oleaje de las orbitas satelitales de JASON-1. La metodologia se basa en la teoria de perturbaciones pequenas para un funcional que minimiza el error cuadratico del modelo, corrigiendo unas constantes responsables por los procesos fisicos de generacion, disipacion y la transformacion no-lineal del espectro
A survey of speech-hand gesture recognition for the development of multimodal interfaces in computer games

Hand gestures and speech constitute one of the most important modalities in human-to-human communication. The investigation of this phenomenon has been the focus of research about multimodal interfaces for speech and hand gesture recognition in human computer interaction(HCI). Computer games, as one of the most popular application areas of HCI, are likely to make use of this technology. Integration of speech and gesture in computer games make game play more enjoyable. This article does not intend to cover exhaustively all the issues related to multimodal interface creation in computer games. We primarily discuss some of the key issues related to multimodal interfaces for speech and hand gesture recognition and present a survey of current approaches to overcome the problems faced in this area.
[Antiulcer effect of polycyclicamine compound HH01 on experimental gastric ulcer in rats].

HH01(1-methyl-3,4,5,6,9,10-hexahydro-7H-cyclopenta [j,k]-1,3-dioxolo [4,5-h]-pyrrolo[2,1-b] [3]-benzazepine) A and B in doses 30 mg.kg-1 and 60 mg.kg-1 were shown to protect gastric mucosa of rats from damage induced by absolute ethanol, cold-immersion stress and pylorus ligation. No effect was found in indomethacin model in mice. HH01 was found to decrease secretion of gastric juice and HCl in pylorus ligated rats. The content of DNA in gastric juice of animals treated with HH01 was lower than in control. The results suggest that HH01 is effective as an anti-ulcer agent, but its mechanism of action is yet unknown.
Targeting the hepatocyte growth factor/mesenchymal epithelial transition pathway in gastric cancer: biological rationale and clinical applications

Advanced gastric cancer (GC) is a dreadful disease with a poor prognosis and the majority of patients die within 1 year of diagnosis. In the past decade, important signaling pathways promoting tumor proliferation and aggressiveness have been evaluated; the hepatocyte growth factor/mesenchymal epithelial transition (MET) pathway is one of the most promising pathways in that regard. This pathway has been evaluated in preclinical and early clinical settings of GC. From the very early studies, MET expression has been recognized as an important poor prognostic marker in GC. However, only after the development of MET-targeting agents, it became important in terms of antitumor therapy with the clinical evaluation of several MET-targeting agents in GC. The results of the ongoing multicenter studies evaluating MET-targeting agents are eagerly awaited as they may improve our understanding of the precise role of these agents in the treatment armamentarium of advanced GC.
Digital identity and mistake

This article examines the impact of digital identity on commercial transactions, with a focus on mistake in contract when an individual’s digital identity is misused by another person. The article asserts that digital identity is emerging as a distinct new legal concept in the USA and Australia, as both countries move to fully digitalize government transactions. In both countries, these new schemes are being introduced without fanfare, through subtle, gradual change. These schemes are significant because they establish one identity, initially for use in transactions with government, but with the long-term consequence of also extending to transactions with the private sector. The implications of this change, and the nature and functions of the set of information that constitutes an individual’s identity for transactions, are examined. The analysis reveals that digital identity, in this context, consists of two sets of information. The primary set of information constitutes an individual’s transactional identity. As its name suggests, this is the identity required for transactions. Transaction identity is a defined set of information that typically consists of full name, date of birth, gender and identifying information such as a signature and/or a unique number. The article analyses the legal nature and functions of transaction identity in the context of commercial transactions. The article considers the central question of who, or what, is the legal person in the transaction, that is, who or what enters into legal relations. The analysis presents some intriguing results in relation to contract and mistaken identity. The article discusses the implications for the USA and Australia because of their notable similarities in terms of the type of scheme, strategy for implementation and legal system. However, the analysis has wider application to other jurisdictions. The emergence of a concept of digital identity has implications for countries with formal national identity schemes, as well as for those establishing schemes through gradual change such as those now being out in place in Australia and the USA.
Automatic Accurate Cost-Bound Analysis for High-Level Languages

This paper describes a language-based approach for automatic and accurate cost-bound analysis. The approach consists of transformations for building cost-bound functions in the presence of partially known input structures, symbolic evaluation of the cost-bound function based on input size parameters, and optimizations to make the overall analysis efficient as well as accurate, all at the source-language level. The calculated cost bounds are expressed in terms of primitive cost parameters. These parameters can be obtained based on the language implementation or can be measured conservatively or approximately, yielding accurate, conservative, or approximate time or space bounds. We have implemented this approach and performed a number of experiments for analyzing Scheme programs. The results helped confirm the accuracy of the analysis.
An Approach to Business Processes Reengineering Based on Integration of the Process Mining Methods and Domain Specific Modeling Tools

An approach to reengineering business processes through the integration of the domain specific modeling platform and Process Mining tools is described. An analysis of the existing approaches to business processes improvement is presented and restrictions are shown. The Process Mining methods are related to business process reengineering stages and tasks. Comparative analysis of Process Mining tools is executed. The advantages of the using of domain specific modeling tools (language workbenches, DSM platforms) are substantiated. Brief comparison of various visual languages notations and model transformation examples are described. The DSM platform ensures mutual understanding between specialists. The MetaLanguage DSM platform is the basis of integration tools. Some DSL (metamodels) are described and transformations are illustrated. The implementation of integrated tools reduces the complexity of analyst’s work.
Robust estimation of magnetic Barkhausen noise based on a numerical approach

This paper deals with a multi-features numerical instrument to estimate and qualify Barkhausen noise. Starting from traditional instruments based on RMS value of the band-pass filtered measured signal, the proposed method is based on the simultaneous analysis of the excitation voltage, the excitation current and the induced signal. The aim is to overcome the well-known limits in terms of measurement repeatability and noise immunity. A good repeatability improvement is achieved by monitoring the excitation impedance, while synchronizing the RMS evaluation to the excitation current signal increases the robustness with respect to the environmental electromagnetic noise. Moreover, the use of shape-based parameters is encouraged to better qualify the Barkhausen signal.
Environments of strong/ultrastrong, ultraviolet Fe II emitting quasars

We have investigated the strength of ultraviolet (UV) Fe ii emission from quasars within the environments of large quasar groups (LQGs) in comparison with quasars elsewhere, for 1.1 ≤ z_(LQG) ≤ 1.7, using the DR7QSO catalogue of the Sloan Digital Sky Survey. We use the Weymann et al. W2400 equivalent width, defined between the rest-frame continuum windows 2240–2255 and 2665–2695 A, as the measure of the UV Fe ii emission. We find a significant shift of the W2400 distribution to higher values for quasars within LQGs, predominantly for those LQGs with 1.1 ≤ z_(LQG) ≤ 1.5. There is a tentative indication that the shift to higher values increases with the quasar i magnitude. We find evidence that within LQGs the ultrastrong emitters with W2400 ≥ 45 A (more precisely, ultrastrong plus with W2400 ≥ 44 A) have preferred nearest-neighbour separations of ∼30–50 Mpc to the adjacent quasar of any W2400 strength. No such effect is seen for the ultrastrong emitters that are not in LQGs. The possibilities for increasing the strength of the Fe ii emission appear to be iron abundance, Lyα fluorescence and microturbulence, and probably all of these operate. The dense environment of the LQGs may have led to an increased rate of star formation and an enhanced abundance of iron in the nuclei of galaxies. Similarly, the dense environment may have led to more active blackholes and increased Lyα fluorescence. The preferred nearest-neighbour separation for the stronger emitters would appear to suggest a dynamical component, such as microturbulence. In one particular LQG, the Huge-LQG (the largest structure known in the early Universe), six of the seven strongest emitters very obviously form three pairings within the total of 73 members.
MAGNESIUM AND ITS ESSENTIAL ROLE IN HEALTH

Magnesium has a very important role and function in life. It is one of the familiar metals that, in minute amounts, is necessary for bodyâ€™s proper metabolism to occur. It normally occurs at low concentrations and is known as a trace metal. Its bioavailability may change due to aging. A number of surveys show magnesium intake by old persons to be lower than the corresponding reference nutrient intakes, however, its deficiency among the elderly is also well documented, especially among the institutionalised and people with pathologies1 .
A northern glacial refugium for bank voles (Clethrionomys glareolus)

There is controversy and uncertainty on how far north there were glacial refugia for temperate species during the Pleistocene glaciations and in the extent of the contribution of such refugia to present-day populations. We examined these issues using phylogeographic analysis of a European woodland mammal, the bank vole (Clethrionomys glareolus). A Bayesian coalescence analysis indicates that a bank vole population survived the height of the last glaciation (≈25,000–10,000 years B.P.) in the vicinity of the Carpathians, a major central European mountain chain well north of the Mediterranean areas typically regarded as glacial refugia for temperate species. Parameter estimates from the fitted isolation with migration model show that the divergence of the Carpathian population started at least 22,000 years ago, and it was likely followed by only negligible immigration from adjacent regions, suggesting the persistence of bank voles in the Carpathians through the height of the last glaciation. On the contrary, there is clear evidence for gene flow out of the Carpathians, demonstrating the contribution of the Carpathian population to the colonization of Europe after the Pleistocene. These findings are consistent with data from animal and plant fossils recovered in the Carpathians and provide the clearest phylogeographic evidence to date of a northern glacial refugium for temperate species in Europe.
Intensive antileukemic treatment of patients younger than 65 years with myelodysplastic syndromes and secondary acute myelogenous leukemia

Intensive antileukemic treatment was evaluated in 22 patients with secondary acute myelogenous leukemia (sAML) and 14 patients with myelodysplastic syndrome (MDS). Results of combination remission‐induction chemotherapy were compared with 126 patients contemporarily treated for primary AML. The duration of hypoplasia, induced by remission induction chemotherapy, tended to be longer in the sAML and MDS patients when compared to de novo AML, but reached significance only for the duration of thrombocytopenia: 26 days versus 18 days (P <0.01). The number of hypoplastic deaths during remission‐induction chemotherapy of patients with sAML and MDS was low. Four of the 36 patients treated for sAML or MDS died during hypoplastic phases induced by remission‐induction chemotherapy. The complete remission (CR) rates were similar in primary AML (67%), sAML (62%), and MDS (64%). The CR rates of patients younger than 45 years were 75% for de novo AML, 75% for sAML, and 71% for MDS. Remission rates in patients older than 45 years were identical in the three subgroups but significantly (P < 0.005) inferior to those obtained in younger patients: 56%, 50%, and 57%, in de novo AML, sAML, and MDS, respectively. The remission duration without bone marrow transplant (BMT) was significantly shorter (P < 0.01) in MDS and sAML when compared with primary AML. Long‐lasting CR in MDS and sAML was only obtained in three of the six patients treated with allogeneic BMT. Intensive antileukemic therapy could be considered in young patients with MDS and life‐threatening cytopenias or patients with sAML.
Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study.

CONTEXT Exercise training is associated with improved insulin sensitivity (SI), but the potential impact of habitual, nonvigorous activity is uncertain. OBJECTIVE To determine whether habitual, nonvigorous physical activity, as well as vigorous and overall activity, is associated with better SI. DESIGN A multicultural epidemiologic study. SETTING The Insulin Resistance Atherosclerosis Study, conducted in Oakland, Calif; Los Angeles, Calif; the San Luis Valley, Colo; and San Antonio, Tex. PARTICIPANTS A total of 1467 men and women of African American, Hispanic, and non-Hispanic white ethnicity, aged 40 to 69 years, with glucose tolerance ranging from normal to mild non-insulin-dependent diabetes mellitus. MAIN OUTCOME MEASURE Insulin sensitivity as measured by an intravenous glucose tolerance test. RESULTS The mean SI for individuals who participated in vigorous activity 5 or more times per week was 1.59 min(-1) x microU(-1) x mL(-1) x 10(-4) (95% confidence interval [CI], 1.39-1.79) compared with 0.90 (95% CI, 0.83-0.97) for those who rarely or never participated in vigorous activity, after adjusting for potential confounders (P<.001). When habitual physical activity (estimated energy expenditure [EEE]) was assessed by 1-year recall of activities, the correlation coefficient between SI and total EEE was 0.14 (P<.001). After adjustment for confounders, vigorous and nonvigorous levels of EEE (metabolic equivalent levels > or = 6.0 and <6.0, respectively) were each positively and independently associated with SI (P< or =.01 for each). The association was attenuated after adjustment for the potential mediators, body mass index (a measure of weight in kilograms divided by the square of the height in meters), and waist-to-hip ratio. Results were similar for subgroups of sex, ethnicity, and diabetes. CONCLUSIONS Increased participation in nonvigorous as well as overall and vigorous physical activity was associated with significantly higher SI. These findings lend further support to current public health recommendations for increased moderate-intensity physical activity on most days.
Intravenous Administration of Human Umbilical Tissue-Derived Cells Improves Neurological Function in Aged Rats after Embolic Stroke

Intravenous administration of human umbilical tissue-derived cells (hUTC) improves neurological function in young adult rats after stroke. However, stroke is a major cause of death and disability in the aged population, with the majority of stroke patients 65 years and older. The present study investigated the effect of hUTC on aged rats after embolic stroke. Rats at the age of 18–20 months were subjected to embolic middle cerebral artery (MCA) occlusion. Two groups of eight animals each were compared. The investigational group was injected intravenously with 1 × 107 cells/kg in serum-free culture medium (vehicle) 24 h after stroke onset, and the control group was treated with vehicle only at the same time poststroke. Intravenous administration of hUTC significantly improved neurological functional recovery without reducing infarct volume compared to vehicle-treated aged rats. Additionally, hUTC treatment significantly enhanced synaptogenesis and vessel density in the ischemic boundary zone (IBZ). Moreover, hUTC treatment resulted in a trend toward increased progenitor cell proliferation in the subventricular zone (SVZ) compared to vehicle-treated aged rats. Intravenous administration of hUTC improved functional recovery in aged rats after stroke. The enhancement of synaptogenesis and vessel density may contribute to the beneficial effects of hUTC in the treatment of stroke in the aged animal.