Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparaison de six méthodes de dosage indirect du cholestérol LDL chez des personnes vivant avec le VIH à Libreville

L’objectif de cette etude etait, de comparer six methodes de dosage indirect du cholesterol LDL en vue de mettre en place une methode plus pertinente dans le suivi des modifications cardiometaboliques chez les personnes vivant avec le VIH (PVVIH) sous traitements. Il s’agissait d’une etude prospective descriptive et analytique chez des PVVIH sous antiretroviraux a Libreville, allant du 13 aout au 30 novembre 2018. Les patients de plus de 15 ans ont ete inclus apres avoir donne leurs consentements. Le dosage du cholesterol total, cholesterol HDL, cholesterol LDL et triglycerides a requis un automate multi analyseur (BS 200 de Mindray®) ainsi que des kits « BIOLABO ». La regression lineaire etait utilisee pour rechercher les differentes correlations. Les valeurs de triglycerides <150mg/dL etaient retrouvees chez 96% de la population et 52% avait une concentration de cholesterol HDL <40mg/dL. Les differentes formules de calcul de la concentration du cholesterol LDL par rapport aux concentrations de LDL cholesterol direct ont montre que le carre du coefficient de correlation lineaire r etait plus eleve pour la formule d’Anandaraja (r2 = 0,83), suivi de celle de Friedewald avec r2 = 0,72. Un palliatif au dosage direct pourrait etre l’utilisation de la formule d’Anandaraja dans notre contexte d’etude.Mots cles : Cholesterol LDL, Cholesterol total, Methode indirecte, VIH, Anandaraja, Friedewald. Comparison of six indirect LDL cholesterol methods among HIV patients in Libreville The objective of this study was to compare six methods of indirect measurement of LDL cholesterol for setting a more relevant method of monitoring cardiometabolic changes in people living with HIV under treatment. This was a prospective descriptive and analytic study among people living with HIV and under antiretroviral therapy in Libreville, from 13 August to 30 November 2018. Patients over 15 years of age were included after giving their consent. The dosage total of cholesterol, HDL cholesterol, LDL cholesterol and triglycerides required a multi analyzer BS 200 of Mindray® and reagents kits from BIOLABO. Linear regression was used to found different correlations. Triglyceride values below 150 mg/dL were found among 96% of the population and 52% had HDL cholesterol concentration below 40 mg/dL. The different formulas for calculating the LDL cholesterol concentration relative to the direct LDL cholesterol concentrations show that the square of the linear correlation coefficient r is higher for the Anandaraja formula (r2 = 0.83) followed by that of Friedewald with r2 = 0.72. A palliative method to the direct assay could be the use of Anandaraja's formula in our context.Keywords: LDL cholesterol, Total cholesterol, Indirect method, HIV, Anandaraja, Friedewald.
An Interactive Clustered base Recommender system for effective Social Data Analysis

Providing or proposing appropriate material based on the essence of expertise is the most important and checking topic in recommender schemes. While collaborative filtering (CF) is one of the most visible and well documented procedures used for recommender schemes, we suggest another clustering-based CF (CBCF) technique using an incentivized / penalised user (IPU) model only with the appraisals provided by users, which is therefore easy to actualize. We aim to build this fundamental clustering technique without prior data and at the same time improve the consistency of the recommendation. Towards being real, CBCF and an IPU model are inspired by enhanced suggestion execution by cautiously misusing different tendencies among consumers, such as consistency, recall and an F1 scoring. In specific, we are speaking of a convincing enhancement topic in which we aim to extend the recall (or F1 score comparably) for a certain accuracy. For this reason, users are divided through a few clusters depending on the real data assessment and coefficient of Pearson correlation. Some time since, we are both encouraging in a common category by the tendency for interest by the customers. The test results indicate a tremendous change in the pattern of the CF tract without clustering the reminder or F1 score for certain accuracy.
Effects of Early Neurological Deterioration in Acute Ischemic Stroke on Multiple Dimensions of Functional Outcomes Using Propensity Score Matching Analysis

Background: Early neurological deterioration (END) is common in acute ischemic stroke (AIS), but its effect on functional outcomes is not well understood. The aim of the present study was to explore the effects of END on multiple dimensions of functional outcomes.Methods: In the present study, 256 patients with AIS were analyzed. All patients were followed up for 1 year. We used the modified Rankin Scale (mRS) to assess body function impairment, the Lawton activities of daily living scale to assess activity limitations, and the reintegration to normal living index (RNLI) to assess participation restrictions. Brain magnetic resonance imaging was performed to identify acute infarcts and preexisting abnormalities, such as white matter lesions, medial temporal lobe atrophy, microbleeds, and silent lacunae. To reduce the effects of a lack of randomization, we conducted a propensity score analysis. Results: The study sample consisted of 185 men (72.3%) and 71 women (27.7%). Sixty-one patients (23.8%) had END. Before matching, patients with END had higher levels of small artery-type stroke, higher National Institutes of Health Stroke Scale scores on arrival, higher systolic blood pressure on admission, and larger infarct volumes. After matching, there were no significant differences between the two groups in any clinical or neuroimaging variables, except for stroke subtype and cortical region infarct. Logistic regression analysis revealed that END was a significant predictor of poor mRS (odds ratio [OR], 3.829; 95% confidence interval [CI], 1.367–10.723, p = 0.011) and poor RNLI (OR, 2.777; 95% CI, 1.133–6.806, p = 0.026) scores after adjusting for confounding factors.Conclusions: END is relatively common in AIS, with an incidence of 23.8%. END might be able to predict poor functional outcomes, including body function impairment and reduced social participation.
Developing and Testing an Algorithm to Identify Future Innovative Research Areas in Digitalization Conditions (using a Medical-sector example)

Predicting more relevant areas of medical research, with a prediction period starting at five years, is currently done exclusively by experts, while the results of such forecasts are extremely ineffective and differ significantly, depending on their source. Modern development trends in world science require the creation of a universal forecasting tool that can be used as a basic resource— providing objective, system-independent information. This condition justifies the relevance of the present study. This study’s goal was to develop and test an algorithm to identify future innovative research areas in digitalization conditions (using the medical sector as an example). During this research, a prognostic model was developed based on the hype cycle, which makes determining a list of possible areas for hardware development in the medical sector possible, presenting this list as a set of tokens that are decoded using mental analysis and automated through the Python programming language. The process of identifying future innovative research areas comprises the following stages: identifying the aggregator (hub) research results, parsing primary information, translating the analyzed information, forming a set of lexemes, forming an analytical dataframe, constructing regression models for the highlighted lexemes, forming and storing the resulting dataframe, and metathinking the highlighted lexemes. In total, 4,000 study names were analyzed, based on the ResearchGate platform, which made obtaining 28 significant lexemes based on the results of metathinking possible. Next, an associative map was created using the most promising research areas in medicine, namely: diagnosing viral infections, the spread of viral infections, coronaviruses, cardiovascular diseases, and lung diseases. The obtained algorithm for the automatic determination of promising research areas can be modified by choosing different sources of information.
Influence of Nitrogen and Saline Water on the Growth and Partitioning of Mineral Content in Maize

ABSTRACT Saline irrigation water has a tremendous impact on the yield potential of crops. Distribution of mineral elements in the parts of maize plant in response to saline water and nitrogen (N) nutrition was studied in a pot experiment for six weeks. Plants were irrigated either with tap water or saline water (ECw: 3.2 dSm−1). Nitrogen was applied at the rate of 0, 50, 100 and 200-kg ha−1 denoted as N0, N1, N2, and N3, respectively. Plants were separated into leaf, stem and root and analyzed for N, calcium (Ca), magnesium (Mg), sodium (Na), and potassium (K) concentrations. Dry matter production of leaf, stem and root was significantly reduced with saline water. The partitioning of elements in plants was the function of nitrogen and saline water. The N concentration of plant parts varied in the order of leaf > stem > root. A significant decrease in the N content was noted in plants under saline water. The root contained the highest Na content, Ca and Mg were higher in the leaf, whereas K was highest in the stem under saline water. Sodium was highest in the root and the remainder elements were greatest in the stem under tap water. Potassium and Cl were significantly reduced by N level whereas the reverse was true for Ca, Mg and Na content. The Na/K, Na/Ca, and Na/Mg ratios were also higher in salt stressed plant parts due to higher accumulation of Na ion. Among N-fertilizer treatments the Na/Ca and Na/Mg ratios were highest in control whereas Na/K increased with the addition of N. This study indicated that interaction of saline water and nitrogen has mixed effects on the partitioning of mineral elements in maize.
Electronic Interactions and Interchromophore Excitation Transfer

The nature and variation of the electronic interactions which promote the transfer of singlet electronic excitation between two chromophores are elucidated using a simple four-electron model as a foundation. Two important distance regimes for excited-state intermolecular interactions can be distinguished: short range (ca. 3-6 A) and intermediate range (ca. 6-20 A). A unifying model is presented which accounts for both interchromophore orbital overlap effects, which dominate at short-range (using a variational treatment) and intermediate-range interactions (by a quantum electrodynamical description). It is shown that penetration as well as exchange effects are important at close separations
Topical Applications of Antioxidants for Atopic Dermatitis

Atopic dermatitis is a skin disease which majorly affects the children. It can be caused by dust, mites,pets and food allergens. Atopic dermatitis is induced by the allergens and ends up in the elevated level ofImmunoglobulin G. People from the developing countries such as New Zealand and U.S are more proneto atopic dermatitis skin disease because of the low level of melanin production in their skin. This canbe reduced by the use of natural compounds such as glutathione derived from plants. In this article, thefunctioning and active molecules of glutathione for atopic dermatitis are discussed.
Waste Management Free Tourism Program Based on Waste Management in the Mandeh Tourism Area of Pesisir Selatan Regency

Waste Management Free Tourism Program Based on Waste Management in the Mandeh Tourism Area of Pesisir Selatan Regency This community service aims to increase community knowledge and awareness in managing household waste into economical products. The method used is to apply the concept of zero waste management or reduce waste independently by collecting, selecting, and managing dry waste. The results of dedication show that (1) a caring or environmentally conscious group or community has been formed, namely the Nagari Mandeh Waste-Free Environmental Care Group consisting of Housewives; (2) an increase in community knowledge and understanding of waste management and environmental awareness by not littering as seen from the behavior of collecting and sorting waste; and (3) increasing people's understanding of the management of dry waste into products that have economic value and can bring income to those who are seen from behaviors that have used waste to become economic products such as decorative broomsticks made from palm leaves and plastic waste and accessories (brooches), decorative bun, box pins, and once) from waste plastic. Keywords: Waste-Free Tourism, Zero Waste Management
Microalgae‐promoted photodegradation of two endocrine disrupters in aqueous solutions

BACKGROUND: Photodegradation is one method to remove the organic pollutants in wastewater. The photodegradation of 17α-ethynylestradiol (EE2) and 17β- estradiol (E2) was investigated using freshwater algae suspended in aqueous solutions under a high-pressure mercury lamp (250 W). Three algal species were used: Chlorella vulgaris (CV), Anabaena cylindrica (AC) and Microcytis aeruginosa kutz (MA). Reactions were carried out under aerobic conditions. RESULTS: The three algal species are capable of promoting the photodegradation of EE2 and E2. For example, in the A. cylindrica suspensions, with cell density ranging from 7.0 × 105 cells mL−1 to 8.4 × 106 cells mL−1, the photodegradation rate of EE2 was increased from 14% to 28%. Reactive oxygen species were thought to be the main reason for the degradation of endocrine disrupting chemicals (EDCs). Hydroxyl radicals and singlet oxygen photogenerated in the algal suspensions were detected. About 4 µmol L−1 hydroxyl radicals were generated in the 4 h reaction. CONCLUSION: Oxidative photodegradation of a solution of endocrine disrupters promoted by algae leads to noticeable decrease in the toxicity of the solution. Oxygen plays an important role in the formation of reactive oxygen species in the algal suspensions. Copyright © 2008 Society of Chemical Industry
Production of Concrete Using Diverted Rainwater First Flush

Rainwater harvesting is a primordial practice gaining acceptance for its fundamental quality. The most stimulating aspect of rainwater harvesting is the methods of capture, storage, and use of this natural resource. Pollutants are accumulated on the roof during dry weather and then washed off at the beginning of a rain event. This contaminated volume of water at the initial stage of a rainfall is known as “first flush”. This study involves the applied use of this foul water as an alternative to potable water in concrete making and compared its performance with the conventional potable water. Water quality tests of diverted rainwater to find out its impact on the prepared concrete and on the usual mix design procedure for preparing concrete are also shown here. After analysing the result, it is established that concrete production can be done in a more environmentally sound way regarding the use of water resources. Construction sector consumes a high volume of water resources. If we can divert the initial dirty water of rainfall events, collect and store it properly, it can be an alternative to the potable water that is being used to produce concrete, maintaining the quality of the concrete.
Radiographic Visibility Limit of Pores in Metal Powder for Additive Manufacturing

The quality of additively manufactured (AM) parts is determined by the applied process parameters used and the properties of the feedstock powder. The influence of inner gas pores in feedstock particles on the final AM product is a phenomenon which is difficult to investigate since very few non-destructive measurement techniques are accurate enough to resolve the micropores. 3D X-ray computed tomography (XCT) is increasingly applied during the process chain of AM parts as a non-destructive monitoring and quality control tool and it is able to detect most of the pores. However, XCT is time-consuming and limited to small amounts of feedstock powder, typically a few milligrams. The aim of the presented approach is to investigate digital radiography of AM feedstock particles as a simple and fast quality check with high throughput. 2D digital radiographs were simulated in order to predict the visibility of pores inside metallic particles for different pore and particle diameters. An experimental validation was performed. It was demonstrated numerically and experimentally that typical gas pores above a certain size (here: 3 to 4.4 µm for the selected X-ray setup), which could be found in metallic microparticles, were reliably detected by digital radiography.
Changes in Proline Levels during Seed Development of Orthodox and Recalcitrant Seeds of Genus Acer in a Climate Change Scenario

In the present study, we examined the utility of proline usage as a biochemical indicator of metabolic changes caused by climate change (mean temperature and precipitation) during seed development of two Acer species differing in desiccation tolerance: Norway maple (Acer platanoides L.—desiccation tolerant—orthodox) and sycamore (Acer pseudoplatanus L.—desiccation sensitive—recalcitrant). In plants, proline is an element of the antioxidant system, which has a role in response to water loss and high temperatures. Our study considered whether proline could be treated as an indicator of tree seed viability, crucial for genetic resources conservation. Proline content was measured biweekly in developing seeds (between 11 and 23 weeks after flowering) collected in consecutive years (2017, 2018, and 2019). We showed that proline concentrations in recalcitrant seeds were positively correlated with mean two-week temperature. In contrast, in orthodox seeds no such relationship was found. Proline content proved to be sensitive to thermal-moisture conditions changes, which makes it a promising biochemical marker of seed desiccation tolerance in different climatic conditions.
Method of dynamic selection of regression tests during developing multimodule information systems in conditions of CI/CD

The article considers the forming a pool of regression tests when using the CI/CD process in the development of information systems consisting of a significant number of interacting modules and using various database management systems. The reasons that do not allow using standard filters of testing management systems to account for possible interactions between modules of the developed information system are indicated. The method of selection of the tests to consider the interaction and potential mutual influence of modules on each other, which also minimizes the pool of selected tests, and rank tests for significance from the point of view of a decision on the correctness of the implementation of the functionality of the information system and the system's readiness for its transfer to the customer. The method of dynamic selection of tests that allow to quickly evaluate changes made to the components of the information system in terms of possible negative impact on the unaffected components and functionality is considered. The advantages and disadvantages of the considered methodology, the necessary conditions for its successful application, and ways to implement it both in new projects for the development of information systems and in existing projects in continuous development and without the possibility of organizing code freezing are given.
Dendrosomes: a novel family of vehicles for transfection and therapy

Hereby we report the transfection performance of a new family of synthetic vehicles having spherical dendritic structures readily made and utilized in direct delivery of genes into cells and model animals. Besides their ease of preparation and storage they enjoy some unique advantages, eg they are inexpensive, inert, highly stable and easy to handle and apply compared with other existing synthetic vehicles for gene delivery (cationic lipids, dendrimers and liposomes). Data obtained thus far on cell cultures and animal models have irrevocably demonstrated their inertness as well as their impressive performance in easy, quick and direct transfections, which include: (1) Direct delivery of plasmid, pEcoRI-E (origin of replication of VZV) and pNN2 (containing HSV1 polymerase gene) into human kidney (G293, Vero) and hepatocyte (Huh7) cell cultures, by simply mixing each of these plasmids with the dendrosome for a very short period and exposing it to the target cell in culture. (2) Direct intramuscular (IM) or intradermal (ID) injection of mixture of a dendrosome with CMV containing the gene for hepatitis B surface antigen into BalbC mice. Here it is found that as a high a ratio of plasmid/ dendrosome as 150 (or even higher in second and third injections) can be easily achieved, which elicits a quick and intense immune (antibody) response compared with common methods (eg 20% sucrose) or recombinant antigen vaccines.
Zinc Finger Protein 1 (ZFP1) Is Involved in Trichome Initiation in Arabidopsis thaliana

Arabidopsis trichome is specialized structure that develops from epidermal cells, and is an excellent model system for studying various aspects of plant cell development and cell differentiation. Our previous studies have shown that C2H2 zinc finger protein family genes, including GIS, GIS2, GIS3, ZFP5, ZFP6 and ZFP8, play an important role in controlling trichome initiation in Arabidopsis. Here, our novel results showed a C2H2 zinc finger protein, ZFP1, which also plays an important role in trichome initiation in Arabidopsis. ZFP1 over-expression lines display significantly increased trichome number on cauline leaves, lateral branches and main stems in comparison with wild type plants. ZFP1 RNAi lines and loss-of-function mutants showed the opposite phenotype. Furthermore, our study also found that ZFP1 mediates the regulation of trichome initiation by cytokinin signaling. The molecular and genetic analyses reveal that ZFP1 acts upstream of key trichome initiation factors, GL3 and TRY.
Determination of F2-isoprostanes in cultured human lung epithelial cells after exposure to metal oxide and silica nanoparticles by high-performance liquid chromatography/tandem mass spectrometry

The environmental impact of nanotechnology has caused a great concern. Many in vitro studies showed that many types of nanoparticles were cytotoxic. However, whether these nanoparticles caused cell membrane damage was not well studied. F2-isoprostanes are specific products of arachidonic acid peroxidation by nonenzymatic reactive oxygen species and are considered as reliable biomarkers of oxidative stress and lipid peroxidation. In this article, we investigated the cytotoxicity of different nanoparticles and the degree of cellular membrane damage by using F2-isoprostanes as biomarkers after exposure to nanoparticles. The human lung epithelial cell line A549 was exposed to four silica and metal oxide nanoparticles: SiO2 (15 nm), CeO2 (20 nm), Fe2O3 (30 nm), and ZnO (70 nm). The levels of F2-isoprostanes were determined by using high-performance liquid chromatography/mass spectrometry. The F2-isoprostanes’ peak was identified by retention time and molecular ion m/z at 353. Oasis HLB cartridge was used to extract F2-isoprostanes from cell medium. The results showed that SiO2, CeO2, and ZnO nanoparticles increased F2-isoprostanes levels significantly in A549 cells. Fe2O3 nanoparticle also increased F2-isoprostanes level, but was not significant. This implied that SiO2, CeO2, ZnO, and Fe2O3 nanoparticles can cause cell membrane damage due to the lipid peroxidation. To the best of our knowledge, this is the first report on the investigation of effects of cellular exposure to metal oxide and silica nanoparticles on the cellular F2-isoprostanes levels.