Miracle-dz/UniFAR-FTUs huggingface dataset:
[Prevalence of acute cerebrovascular disease in Bizovac, Osijek-Baranya county: a door-to-door survey in eastern Croatia].

BACKGROUND AND PURPOSE A door-to-door survey was carried out in Bizovac area, Osijek-Baranya County in east Croatia. A cluster sample of 1899 inhabitants were screened to determine the prevalence of acute cerebrovascular disease (CVD): transient ischemic attacks (TIA) and stroke in this population. METHODS We used a modified version of the World Health Organization screening instrument. A door-to-door survey of stroke was conducted in five Osijek suburbs, east Croatia. The data obtained were compared with data in personal records of the study subjects. RESULTS On March 31, 2005, the prevalence of acute CVD was 3370/100.000 (stroke 1948/100,000 and TIA 1422/100,000), of CVD in males 3047/100,000 (stroke 1959/100,000 and TIA 1088/100,000); of CVD in females 3673/100,000 (stroke 1939/100,000 and TIA 1735/100,000); and the prevalence of acute CVD progressively increased with age: in 45-54 age group 1290/00,000 (stroke 942/100,000, TIA 348/100,000); in 55-64 age group 7895/100,000 (stroke 5623/100,000, TIA 2272/100,000); in 65-74 age group 11386/100,000 (stroke 7393/100,000, TIA 3993/100,000); and in 75-84 age group 14035/100,000 (stroke 10001/100,000, TIA 4034/100,000) as the highest figure. CONCLUSION The study revealed a very high prevalence of acute CVD in the study area and confirmed CVD as one of the leading medical and public health issues in Bizovac area, Osijek-Baranya County, east Croatia.
Protein Kinase A Blocks Raf-1 Activity by Stimulating 14-3-3 Binding and Blocking Raf-1 Interaction with Ras*

Cyclic AMP (cAMP) blocks Raf-1 activation by stimulating its phosphorylation on serine 43 (Ser43), serine 233 (Ser233), and serine 259 (Ser259). We show here that phosphorylation of all three sites blocks Raf-1 binding to Ras.GTP in vivo and that cAMP stimulates binding of 14-3-3 proteins to Ser233 and Ser259. We also show that Raf-1 and protein kinase A (PKA) form a complex in vivo that is disrupted by cAMP and that ablation of PKA by use of small interfering RNA blocks phosphorylation by cAMP. The ability of PKA to block Raf-1 activation is ablated by the PKA inhibitor H89. These studies suggest that Raf-1 and cAMP form a signaling complex in cells. Upon activation of PKA, Raf-1 is phosphorylated and 14-3-3 binds, blocking Raf-1 recruitment to the plasma membrane and preventing its activation.
Magnetic field mapping as a support for UAV indoor navigation system

Safe indoor flights of unmanned aerial vehicles (UAVs) requires an independent measurement systems, that will enable efficient navigation in the absence of GPS data. One of the many solutions currently being developed is the use of information about changes in the value of the local magnetic field. This paper presents ways of recording, visualizing and mapping local magnetic field changes that can be used as a support for indoor navigation systems. At the beginning we reviewed devices for acquisition of magnetic field strength and the type of data being recorded. In the next step we analyzed the possibilities of visualization of acquired data. Finally the methods used to generate magnetic field maps of enclosed areas have been presented. In each of the aspects covered in this paper, solutions developed by the authors will be described.
Genome Sequence of the Marine Bacterium Vibrio campbellii DS40M4, Isolated from Open Ocean Water

ABSTRACT Vibrio sp. strain DS40M4 is a marine bacterium that was isolated from open ocean water. In this work, using genomic taxonomy, we were able to classify this bacterium as V. campbellii. Our genomic analysis revealed that V. campbellii DS40M4 harbors genes related to iron transport, virulence, and environmental fitness, such as those encoding anguibactin and vanchrobactin biosynthesis proteins, type II, III, IV, and VI secretion systems, and proteorhodopsin.
Links to the Future: Communication Requirements and Challenges in the Smart Grid

Making the smart grid a reality will entail communication capabilities that do not exist in current power grids and their legacy control systems. New grid elements such as distributed energy generation and PHEVs will necessitate changes in these existing communication networks. These changes will be dictated by the need for new control operations that will allow efficient management of these new elements and that cannot be supported by the existing communication infra structure. Moreover, the smart grid will let households man age energy usage more efficiently through AMI and HEMSs. The realization of these systems will require pushing communication networks far out from the network core and deep into homes and buildings. We have presented the communication requirements of the smart grid, and we have identified the main technical challenges that need to be tackled. The only viable way to fulfill these requirements is to design a new communication architecture that can support smart grid services and control operations. This future communication architecture will need to take advantage of the recent progress made in communication technologies and protocols. It will require the introduction of communications technologies that were not considered in the past. In addition, this communication architecture will need to be reliable, scalable, and extendable to future smart grid services and applications.
High CMRR power efficient neural recording amplifier architecture

This work presents an architecture of neural recording amplifier based on a modified differential difference amplifier (DDA). The proposed circuit improves the performance with respect to capacitive feedback neural amplifiers and standard DDA based amplifiers by taking advantage of the high CMRR achievable in a DDA without jeopardizing the power consumption. In addition a novel technique for rejecting the DC component at the output of the amplifier and fixing the low cut-off frequency is described. The expected performance of the circuit is checked by Monte Carlo simulation, achieving 48dB gain in a 250Hz-8kHz bandwidth, with higher than 107dB CMRR (@5kHZ), 2. 4µVrms input noise and 4.2 noise efficiency factor at a total current consumption of 16. 5µA from a 3.3V power supply in a 0. 5µm CMOS technology.
Vmat2 Heterozygous Mutant Mice Display a Depressive-Like Phenotype

The vesicular monoamine transporter 2 (VMAT2) is localized primarily within the CNS and is responsible for transporting monoamines from the cytoplasm into secretory vesicles. Because reserpine (a VMAT inhibitor) can precipitate depressive-like symptoms in humans, we investigated whether Vmat2 heterozygous (HET) mice present with depressive-like behaviors. The mutants showed locomotor and rearing retardation in the open field and appeared anhedonic to 1 and 1.5% sucrose solutions. Immobility times for Vmat2 heterozygotes were prolonged in forced swim and imipramine normalized this behavior. HET animals also showed enhanced immobility in tail suspension and this response was alleviated by fluoxetine, reboxetine, and bupropion. Stimulated GTPγS binding indicated that α2-adrenergic receptors in HET hippocampus were more sensitive to UK 14,304 (5-bromo-N-(4,5-dihydro-1-H-imidazol-2-yl)-6-quinoxalinamine) stimulation than in wild type (WT) mice. In learned helplessness, mice were exposed to a shuttle box for 4 d or were given inescapable foot-shocks for the same time period. On day 5, all animals were tested in shock escape. Failure rates and the latency to escape were similar for WT and HET mice that were only pre-exposed to the test apparatus. In foot-shock groups, learned helplessness was more robust in heterozygotes than in WT controls. Basal secretion of serum corticosterone was not distinguished by genotype; however, corticosterone levels in mutants were more responsive to stress. Anxiety-like responses of WT and HET animals in the open field, light-dark exploration, zero maze, and novelty-suppressed feeding tests were indistinguishable. Collectively, these findings suggest that Vmat2 heterozygotes display a depressive-like phenotype that is devoid of anxiety-like behavior.
Task Mapping for Redundant Multithreading in Multi-Cores with Reliability and Performance Heterogeneity

Due to the architectural design, process variations and aging, individual cores in many-core systems exhibit heterogeneous performance. In many-core systems, a commonly adopted soft error mitigation technique is Redundant Multithreading (RMT) that achieves error detection and recovery through redundant thread execution on different cores for an application. However, <italic>task mapping</italic> and <italic>the task execution mode</italic> (i.e., whether a task executes in a reliable mode with RMT or unreliable mode without RMT) need to be considered for achieving resource-efficient reliability. This paper explores how to efficiently assign the tasks onto different cores with heterogeneous performance properties and determine the execution modes of tasks in order to achieve high reliability and satisfy the tolerance of timeliness. We demonstrate that the task mapping problem under heterogeneous performance can be solved by employing Hungarian Algorithm as subroutine to efficiently assign the tasks onto the cores to optimize the system reliability with polynomial time complexity. To obtain the efficient task execution modes, we also propose an iterative mode adaptation technique and guarantee the tolerable timing constraint. Our results illustrate that compared to state-of-the-art, the proposed approaches achieve up to <inline-formula><tex-math notation="LaTeX"> $80$</tex-math><alternatives><inline-graphic xlink:type="simple" xlink:href="chen-ieq1-2532862.gif"/></alternatives> </inline-formula> percent reliability improvement (on average <inline-formula><tex-math notation="LaTeX"> $20$</tex-math><alternatives><inline-graphic xlink:type="simple" xlink:href="chen-ieq2-2532862.gif"/></alternatives> </inline-formula> percent) under different scenarios of chip frequency variation maps.
Recessively inherited multiple epiphyseal dysplasia with normal stature, club foot, and double layered patella caused by a DTDST mutation

We have observed over 25 different mutations in the diastrophic dysplasia sulphate transporter gene (DTDST) in association with the recessive disorders achondrogenesis 1B, atelosteogenesis 2, and diastrophic dysplasia. The c862t (R279W) transition is the most common mutation in non-Finnish patients, but in these disorders it is usually combined with otherDTDST mutations. We had not seen a case of homozygosity for c862t (R279W) until we analysed DNA from a 36 year old male with tall-normal stature (180 cm) who asked for genetic counselling for suspected multiple epiphyseal dysplasia. He was treated for club foot and hip dysplasia at birth. Skeletal changes consistent with multiple epiphyseal dysplasia, with the peculiar finding of a double layered patella, were recognised during childhood. Cleft palate, swelling of the ear pinna, and hitch hiker thumb were absent. He was found to be homozygous, and both healthy parents heterozygous, for the R279W mutation in DTDST, and his fibroblasts showed a sulphate incorporation defect typical of DTDST disorders. Counselling was given for a recessive disorder, thereby considerably reducing the probability of affected offspring. Multiple epiphyseal dysplasia is more frequently caused by dominant mutations in the COMP (EDM1, McKusick 132400) and COL9A2 genes (EDM2, McKusick 600204). A few other patients and families with features similar to our proband have been described previously and considered to have autosomal recessive MED (EDM4, McKusick 226900). This observation confirms the existence of this entity and assigns it to the phenotypic spectrum associated with mutations at theDTDST locus.
Obesity-Induced Inflammation Is Associated with Alterations in Subcellular Zinc Pools and Premature Mammary Gland Involution in Lactating Mice.

BACKGROUND Lactation failure is common in overweight and obese women; however, the precise mechanism remains unknown. OBJECTIVE We tested the hypothesis that obesity-induced inflammation in the mammary gland (MG) redistributes subcellular zinc pools to promote cell death of mammary epithelial cells (MECs) and premature involution. METHODS Female DBA/2J mice were fed a high-fat (obese; 45% kcal from fat, n = 60) or control diet (lean; 10% kcal from fat, n = 50) for 5 wk and bred. MG cytokines and macrophage infiltration were determined by reverse transcriptase-polymerase chain reaction and F4/80 staining, respectively. Zinc concentration was analyzed by atomic absorption spectroscopy, and zinc transporters and markers of endoplasmic reticulum (ER) stress, autophagy, and involution were measured by immunoblot. To confirm effects of inflammation, tumor necrosis factor-α (TNF) or vehicle was injected into adjacent MGs of lean lactating C57BL/6 mice (n = 5) and cultured MECs (HC11 cells) were treated with TNF in vitro. RESULTS Seventy-seven percent of obese mice failed to lactate (lean: 39%; P < 0.001). Obese mice capable of lactating had greater macrophage infiltration (obese: 135 ± 40.4 macrophages/mm(2); lean: 63.8 ± 8.9 macrophages/mm(2); P < 0.001) and elevated TNF expression (P < 0.05), concurrent with lower zrt- irt-like protein 7 abundance (P < 0.05) and higher ER zinc concentration (obese: 0.36 ± 0.004 μg Zn/mg protein; lean: 0.30 ± 0.02 μg Zn/mg protein; P < 0.05) compared with lean mice. Heat shock protein 5 (HSPA5) expression (P < 0.05) was suppressed in the MG of obese mice, which was consistent with HSPA5 suppression in TNF-injected MGs (P < 0.01) and MECs treated with TNF in vitro (P < 0.01). Moreover, obesity increased lysosomal activity (P < 0.05) and autophagy in the MG, which corresponded to increased zinc transporter 2 abundance and lysosomal zinc concentration compared with lean mice (obese: 0.20 ± 0.02 μg Zn/mg protein; lean: 0.14 ± 0.01 μg Zn/mg protein; P < 0.05). Importantly, MGs of obese mice exhibited markers of apoptosis (P = 0.05) and involution (P < 0.01), which were not observed in lean mice. CONCLUSIONS Diet-induced obesity created a proinflammatory MG microenvironment in mice, which was associated with zinc-mediated ER stress and autophagy and the activation of premature involution.
Fuzzy-Logic-Based $V/f$ Control of an Induction Motor for a DC Grid Power-Leveling System Using Flywheel Energy Storage Equipment

Since natural distribution power generation systems such as wind energy contain electric power fluctuation, flywheel energy storage (FWES) equipment for power compensation is used. Fuzzy-logic-based V/f control of the induction motor is proposed for the speed sensorless power-leveling system in this paper. Only two sensors, including one DC voltage sensor and one DC current sensor, are utilized. The flywheel is composed of two modes, namely, the speed picking-up control mode and the power control mode. According to the DC-link average current of an inverter, the rotating speed of the flywheel in the speed picking-up control mode is detected by regulating the output frequency and the output voltage based on fuzzy logic control. The power control mode consists of the outer voltage loop and the inner current loop. Although the outer loop is also realized by fuzzy logic control, the inner loop is the key object in this paper, i.e., the proportional and integral gains of a proportional-integral regulator are optimized by means of fuzzy logic reasoning for the purpose of the reliability and rapid response of leveling power. The experiments are carried out with the FWES equipment of 40-kJ energy, and the results verify that the proposed method is reliable, and better dynamic and static performance is demonstrated.
Recognition and Classification of Human Behavior in Intelligent Surveillance Systems using Hidden Markov Model

Nowadays, the human behavior analysis by computer vision techniques has been an interesting issue for researchers. Automatic recognition of actions in video allows automation of many otherwise manually intensive tasks such as video surveillance. Video surveillance system especially for elderly care and their behavior analysis has an important role to take care of aged, impatient or bedridden persons. In this paper, we propose a high accuracy human action classification and recognition method using hidden Markov model classifier. In our approach, first, we use star skeleton feature extraction method to extract extremities of human body silhouette to produce feature vectors as inputs of hidden Markov model classifier. Then, hidden Markov model, which is learned and used in our proposed surveillance system, classifies the investigated behaviors and detects abnormal actions with high accuracy in comparison by other abnormal detection reported in previous works. The accuracy about 94% resulted from confusion matrix approve the efficiency of the proposed method when compared with its counterparts for abnormal action detection.
Safety and efficacy of recombinant factor VIIa in patients with liver disease undergoing laparoscopic liver biopsy.

BACKGROUND & AIMS Activated recombinant factor VII (rFVIIa) has been shown to be effective in correcting prolonged prothrombin time (PT) in cirrhotic patients. The main objective of this study was to evaluate the effect of 4 (5, 20, 80, and 120 microg/kg) doses of rFVIIa on correction of PT and the time to achieve hemostasis in cirrhotic patients with coagulopathy who are undergoing laparoscopic liver biopsy. METHODS Seventy-one patients (parts I and II) with advanced liver disease (Child-Turcotte B or C), platelet count > or =60,000/mm3, and PT in the range of 3-15 seconds above normal were included in the study. Efficacy endpoints were normalization of PT and time to hemostasis. RESULTS PT was corrected to normal levels (<13.1 seconds) in the majority of patients. The duration of normalization of PT was longer in patients treated with higher doses of rFVIIa. Forty-eight (74%) of 65 patients (part II) achieved hemostasis within 10 minutes. No correlation between the time to hemostasis and duration of correction of PT was observed. None of the patients required operative intervention or transfusion of blood/blood products to control bleeding. One thrombotic event and one case of disseminated intravascular coagulation were reported, but both events were considered by the investigator as unlikely to be related to treatment with rFVIIa. CONCLUSIONS The results of this study suggest that treatment with rFVIIa may offer benefit for patients with liver disease undergoing laparoscopic biopsy.
An Optimized Space Vector Modulation Sequence for Improved Harmonic Performance

This paper proposes a method for optimization of the harmonic performance of converters under space vector modulation (SVM) control. It is shown that SVM provides a number of degrees of freedom, which make it suitable for optimization, subject to desired constraints. An objective function is defined, which seeks to minimize the most significant harmonic components of the generated waveform while keeping other harmonic components within the acceptable range outlined in the available standards. Since the formulation of the problem involves both real and integer variables, specialized optimization methods capable of handling mixed-integer variables need to be employed, and hence, a genetic algorithm optimizer is used to solve the optimization problem. Optimized SVM sequences obtained for various operating points under different sampling frequencies are shown to result in significant reduction of dominant harmonics while maintaining the waveform quality within prescribed limits.
Milk Intake and Energy Expenditure of Free‐Ranging Northern Fur Seal, Callorhinus ursinus, Pups

Milk ingested by mammalian offspring, coupled with offspring’s utilization of this energetic investment, influences survival and growth. A number of studies have examined milk intake in otariids, but few have examined milk intake over the entire lactation period, and none has independently measured energy expenditure concurrent with milk intake. We concurrently examined milk intake, field metabolic rate (FMR), and body composition of 41 pups over the entire lactation interval in 1995 and 1996 on St. Paul Island, Alaska. One hundred two metabolic measurements were obtained with isotope dilution methods. Mean milk intake did not differ annually but increased with age and mass, ranging from \documentclass{aastex} \usepackage{amsbsy} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{bm} \usepackage{mathrsfs} \usepackage{pifont} \usepackage{stmaryrd} \usepackage{textcomp} \usepackage{portland,xspace} \usepackage{amsmath,amsxtra} \usepackage[OT2,OT1]{fontenc} \newcommand\cyr{ \renewcommand\rmdefault{wncyr} \renewcommand\sfdefault{wncyss} \renewcommand\encodingdefault{OT2} \normalfont \selectfont} \DeclareTextFontCommand{\textcyr}{\cyr} \pagestyle{empty} \DeclareMathSizes{10}{9}{7}{6} \begin{document} \landscape $$3,400\pm 239$$ \end{document} to \documentclass{aastex} \usepackage{amsbsy} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{bm} \usepackage{mathrsfs} \usepackage{pifont} \usepackage{stmaryrd} \usepackage{textcomp} \usepackage{portland,xspace} \usepackage{amsmath,amsxtra} \usepackage[OT2,OT1]{fontenc} \newcommand\cyr{ \renewcommand\rmdefault{wncyr} \renewcommand\sfdefault{wncyss} \renewcommand\encodingdefault{OT2} \normalfont \selectfont} \DeclareTextFontCommand{\textcyr}{\cyr} \pagestyle{empty} \DeclareMathSizes{10}{9}{7}{6} \begin{document} \landscape $$6,780\pm 449$$ \end{document} (±SE) mL per suckling bout. Milk energy consumption did not vary with age on a mass‐specific basis. No differences were detected in milk volume consumed by male and female pups, either absolutely or on a mass‐specific basis. Mass‐specific FMR peaked during molting, was lowest postmolt, and did not vary by sex. Pups in 1995 had lower FMR than pups in 1996 and were also fatter. Mean milk energy utilized for maintenance metabolism decreased over time from 77% to 43% in 1995 and remained at 71% in 1996. Pup body mass was negatively correlated with the percentage of total body water and positively correlated with the percentage of total body lipid (TBL). Pups increased the percentage of TBL from 16% to 37%. Northern fur seal pups increased energy intake over lactation, while concurrent changes in body composition and pelage condition resulted in mass‐specific metabolic savings after the molt.
β-Blocker Prescription and Outcomes in Hemodialysis Patients from The Japan Dialysis Outcomes and Practice Patterns Study

Background/Aims: Given the clear benefits of mortality reduction observed for most β-blockers in clinical trials, they are relatively underused in hemodialysis patients. Since the outcomes associated with the use of β-blockers are not fully known, we investigated their effect on mortality among a cohort of hemodialysis patients. Methods: Data were analyzed from the Dialysis Outcomes and Practice Patterns Study phase II for 2,286 randomly selected patients on hemodialysis in Japan. Treatment with β-blockers was the major predictor variable. The main outcome measure was all-cause mortality. Cox regression analysis was used to assess an association between treatment with β-blockers and the risk of death. Results: 247 patients (11.9%) were administered β-blockers and 1,828 patients (88.1%) were not. Whereas patients treated with β-blockers had a higher prevalence of hypertension and coronary heart disease, Kaplan-Meier analysis revealed that all-cause mortality rates were significantly (p < 0.007) decreased in patients treated with β-blockers compared to those without. In multivariable, fully adjusted models, treatment with β-blockers was also independently associated with reduced all-cause mortality (hazard ratio = 0.48; p = 0.02). Conclusion: This study indicated a possible association between the use of β-blockers and reduced risk of mortality in hemodialysis patients. These results should be confirmed in further randomized controlled trials.