Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of Teaching Learning Method With the Problem Solving to Improve Soft Skill

Based on teaching experience and observations made by the lecturer during lecturing, some of the problems are student’s interest and motivation are decrease and it effected on the passing grade students, the understanding of the students about the subject have to be increased, the soft skill for problem solving is less and the last is the students sometimes afraid to say and share their opinion in the class. The purpose on this paper is how to develop teaching learning method with problem solving to improve soft skill of the students are alsoeffecting the passing rates in the class.
Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers

Significance Gene fusions are tumor-specific genomic aberrations and are among the most powerful biomarkers and drug targets in translational cancer biology. The advent of RNA-sequencing technologies over the last decade has provided a unique opportunity for detecting novel fusions via deploying computational algorithms on public sequencing databases. However, precise fusion detection algorithms are still out of reach. We develop Data-Enriched Efficient PrEcise STatistical fusion detection (DEEPEST), a highly specific and efficient statistical pipeline specially designed for mining massive sequencing databases and apply it to all 33 tumor types and 10,500 samples in The Cancer Genome Atlas database. We systematically profile the landscape of detected fusions via classic statistical models and identify several signatures of selection for fusions in tumors. The extent to which gene fusions function as drivers of cancer remains a critical open question. Current algorithms do not sufficiently identify false-positive fusions arising during library preparation, sequencing, and alignment. Here, we introduce Data-Enriched Efficient PrEcise STatistical fusion detection (DEEPEST), an algorithm that uses statistical modeling to minimize false-positives while increasing the sensitivity of fusion detection. In 9,946 tumor RNA-sequencing datasets from The Cancer Genome Atlas (TCGA) across 33 tumor types, DEEPEST identifies 31,007 fusions, 30% more than identified by other methods, while calling 10-fold fewer false-positive fusions in nontransformed human tissues. We leverage the increased precision of DEEPEST to discover fundamental cancer biology. Namely, 888 candidate oncogenes are identified based on overrepresentation in DEEPEST calls, and 1,078 previously unreported fusions involving long intergenic noncoding RNAs, demonstrating a previously unappreciated prevalence and potential for function. DEEPEST also reveals a high enrichment for fusions involving oncogenes in cancers, including ovarian cancer, which has had minimal treatment advances in recent decades, finding that more than 50% of tumors harbor gene fusions predicted to be oncogenic. Specific protein domains are enriched in DEEPEST calls, indicating a global selection for fusion functionality: kinase domains are nearly 2-fold more enriched in DEEPEST calls than expected by chance, as are domains involved in (anaerobic) metabolism and DNA binding. The statistical algorithms, population-level analytic framework, and the biological conclusions of DEEPEST call for increased attention to gene fusions as drivers of cancer and for future research into using fusions for targeted therapy.
Limits of control in designing distributed C/sup 2/ experiments under imperfect communications

The paper evaluates the controllability of hierarchically organized C/sup 2/ systems with distributed components under conditions of imperfect communications. Controllability in a C/sup 2/ system depends on the number of levels of reporting in the C/sup 2/ hierarchy and the amount of aggregation of events in the feedback to the command levels. Following the discrete event dynamic systems concepts developed by Ramadge and Wonham (1987), a formal control language was defined with its alphabet consisting of controllable and uncontrollable discrete events at the lowest level in the C/sup 2/ hierarchy. At the next level of command, specific patterns of these events are recognized as words. These words, in turn, form the alphabet for a higher level formal control language generated by this automaton and recognized by the automaton at the next higher level of command. In this context, we establish the theoretical limits of control in a C/sup 2/ system for performing a given mission using a selected course of action (COA). Furthermore, introduction of imperfect communications which result in a loss of observability at the command level may render the controllable formal language associated with a selected COA to become uncontrollable. Control by the command level may also be diminished due to the unobservability of events not reported to this level. Theoretical limits of control are computed for a specific C/sup 2/ system modeled as a two level hierarchy of interacting automata under conditions of perfect observability, i.e., perfect communications and total observation of all events. Introduction of observability issues and communication delays in this model is used to demonstrate how a previously controllable language for a selected COA may become uncontrollable resulting in a loss of the mission. We demonstrate that a more conservative COA is then required to ensure that its associated formal language is controllable. <<ETX>>
New Levels of Student Participatory Learning: A WikiText for the Introductory Course in Education

During the summer and fall of 2006, approximately 260 students enrolled in an educational foundations course were responsible for writing their own textbook using the Wikibooks protocol. These students were surveyed in order to determine their perceptions of the process, how the process impacted their involvement in the course and its content, and how their perceptions of the Wikibook differed from their perceptions of traditional textbooks. This research indicates that students valued the process, and were much more involved with their text than when using the traditional bound version.
A quantitative study of differentiated services for the Internet

The differentiated services architecture provides router mechanisms for aggregate traffic, and edge mechanisms for individual flows, that together can be used to build services with varying delay and loss behavior. We compare the loss and delay behavior that can be provided using the services based on combinations of two router mechanisms, threshold dropping and priority scheduling and two packet marking mechanisms, edge-discarding and edge-marking. We compare the delay and loss behavior of the two router mechanisms coupled with edge-discarding for a wide range of traffic arrivals. We observe that priority scheduling provides lower expected delays to preferred traffic than threshold dropping. In addition, we find that a considerable additional link bandwidth is needed with threshold dropping to provide same delay behavior as priority scheduling. We further observe little difference in the loss incurred by preferred traffic under both router mechanisms, except when sources are extremely bursty, in which case threshold dropping performs better. We examine the throughput of a TCP connection that uses a service built upon threshold dropping and edge-marking. Our analysis shows that a significant improvement in throughput can be achieved. However, we find that in order to fully achieve the benefit of such a packet marking, the TCP window must take the edge-marking mechanism into consideration.
Hsa-mir-210 as a novel signature predicts survival in lung squamous cell carcinoma using bioinformatics analysis

In recent years, more and more studies have shown that the expression of miRNAs is closely related to the occurrence of tumors and plays an irreplaceable role in the development and metastasis of tumors. The research was focused on lung squamous cell carcinoma. The data information is downloaded from the TCGA database and analyzed for variance, which is then verified in the GEO database. Then differential expression of miRNAs was found and survival analysis was performed, through the cut – off standard(P<0.05,|logFC|≥2), we screen the 38 up-regulated miRNAs and 14 down-regulated miRNAs from the TCGA. Finally, after the verification on the GEO database, four up-regulated miRNAs (hsa-mir-205, hsa-mir-210, hsa-mir-182, hsa-mir-224) and one down-regulated miRNA (hsa-mir-451) were obtained, which provide a new direction for the diagnosis of lung squamous cell carcinoma. In the survival analysis, it was found that the expression state of hsamir-210 was significantly correlated with patient survival. The results in the univariate and multivariate Cox analysis indicated that hsa-mir-210 was an independent prognostic factor on lung squamous cell carcinoma. The functional enrichment analysis showed that hsa-mir-210 was closely related to positive and negative regulation of cell proliferation, DNA transcription, VEGF signaling pathway, MAPK signaling pathway, hif-1 signaling pathway and choline metabolic pathway. In summary, this study suggested that hsa-mir-210 could be a potential prognostic factor for lung squamous cell carcinoma. Author Summary MicroRNAs are single-stranded small molecular RNA that participate in the regulation of various biological functions through indirect regulation of gene expression, and have been reported to play an important role in the occurrence, development, invasion and metastasis of tumors. In recent years, the research on miRNAs has become increasingly hot, and the role of miRNAs in tumor has been proved more and more. The subjects of this study were squamous cell carcinoma in lung cancer with relatively few studies on miRNAs. Through high-throughput data analysis, miRNAs with differential expression between lung squamous cell carcinoma tissues and normal tissues were found. These differentially expressed miRNAs provide a new direction for the early diagnosis of patients. Then, survival analysis was conducted to find the miRNAs significantly correlated with the total survival time of patients, and multi-factor analysis was conducted to exclude the influence of other clinical factors, and independent risk factors (miRNAs) affecting the survival of patients were determined, so as to provide new targets for the treatment and survival prediction of patients.
Detecting Research Fronts Using Weighted Citation Networks

1 東京大学工学系研究科総合研究機構 Institute of Engineering Innovation, School of Engineering, the University of Tokyo 〒113-8656 東京都文京区弥生2-11-16 E-mail: {fujita, kaji, jmori, isakata}@ipr-ctr.t. u-tokyo.ac. jp 2 東京工業大学イノベーションマネジメント研究科 Tokyo Institute of Technology, Graduate School of Innovation Management 〒108-0023 東京都港区芝浦3-3-6 3 東京大学政策ビジョン研究センター Policy Alternatives Research Institute, the University of Tokyo 〒113-0033 東京都文京区本郷7-3-1 *連絡先著者 Corresponding Author
Evaluation eines Modells zur Talentidentifikation im Grundschulalter

Die Zukunft des Leistungssports in Deutschland hängt neben vielen anderen Faktoren auch von einer wissenschaftlich fundierten und im Feld des Nachwuchsleistungssports (ökologisch) validen Sichtung und Sportartorientierung von Talenten ab. Mit diesem Ziel wurde im Rahmen des Fuldaer Bewegungs-Check 2010-2016 (im Folgenden: FBC) auf der zweiten Klassenstufe eine vielseitige motorische Talentdiagnose (talent screening) mit Hilfe von allgemeinen Testverfahren durchgeführt. Mit Hilfe des Deutschen Motorik-Tests 6-18 (Bös & Schlenker, 2016) sowie ergänzend Ballweitwurf, Komplexer Reaktionslauf, Handkrafttest plus Körperhöhe und -gewicht (im Folgenden: DMT+) wird eine Sportartempfehlung (talent orientation) erstellt und den Kindern zusammen mit ihren Testergebnissen übermittelt. Basis der Sportartempfehlung ist eine aus dem Verhältnis von individuellem Stärken-Schwächen-Profil und sportartspezifischen Anforderungsprofilen abgeleitete Talentprognose. Ziel des vorliegenden Forschungsprojekts war es, das Modell der Talentidentifikation (im Folgenden: TID) und Talentprognose aus konzeptioneller und methodischer Sicht zu validieren. Das umfassende Validitätskonzept (Abb. 1) und die konkret vorgeschlagenen Prüfschritte ermöglichen es, die Treffsicherheit, Wirksamkeit und Nützlichkeit von Bewegungs-Checks in der Grundschule zu evaluieren (Hohmann, Fehr, Siener & Hochstein, im Druck). Dabei geht es nicht alleine im engeren Sinne um die Basisvoraussetzungen der inhaltlichen und kriterienbezogenen Validität der Testung an sich, sondern in einem umfassenderen Verständnis auch um die (mit der Validität eng verwandten) Nebengütekriterien Testökonomie, Zumutbarkeit, Nützlichkeit sowie schlussendlich der gesellschaftlichen Akzeptanz (Moosbrugger & Kelava, 2012). Evaluation eines Modells zur Talentidentifikation im Grundschulalter
Development of a Unified Resource Base for E-Learning

In this paper we propose the notion of unified resource base to simplify the resource exchange, sharing, and access, especial for e-learning. To illustrate the feasibility and advantages of such a unified resource base, we also design and implement a uniform resource management system (URMS). We discuss its functionalities, present its architecture, and demonstrate how its components can be implemented based on current technologies.
Stock trading decision support system using a rule selector based on sliding window

We propose a dynamic decision support system (DDSS) capable of determining a near-optimal rule-combination for each time interval (window). The system provides Buy, Hold and Sell signals from which profitable trading decisions can be made. In DDSS, an intelligent rule selector (GARS) based on genetic algorithms and a sliding window scheme is developed. Experimental results on Taiwan stock exchange weighted stock index (TSEWSI) show that DDSS outperforms its static counterpart as well as the simple buy-and-hold strategy.
Re-configuration and interaction of hydrogen sites in olivine at high temperature and high pressure

Abstract Fingerprinting hydrogen storage sites in olivine at high temperature and high pressure is fundamental to understand water distribution and its impact on the upper mantle. We carried out in situ high-temperature and high-pressure IR spectroscopic investigations on hydrogen storage sites in the natural olivine and synthetic Fe-free forsterite. Based on in situ observations of hydrogen in both the natural olivine and synthetic Fe-free forsterite at high temperatures and high pressures, we find that hydrogen does not transfer between storage sites with increasing temperature, but displays disordering at temperatures over 600 °C. In contrast, pressure can induce re-configuration of hydrogen storage sites corresponding to the 3610 and 3579 cm–1 bands. Hydrogen storage sites also exhibit disordering at high pressure. In addition, the dehydrogenation experiments of the natural olivine indicate interacts of hydrogen storage sites. Protons released from titanium-clinohumite defects move to pure Si vacancies, and also to Mg vacancies coupling with trivalent cations. This study is the first attempt to fingerprint hydrogen storage sites in olivine at high temperature and high pressure using in situ IR spectroscopy. The implications of the temperature- and pressure-induced disordering and re-configuration of hydrogen storage sites are discussed. The disordering and re-configuration of hydrogen storage sites at high temperature and high pressure favor better understanding of the water effects on physical properties of olivine. The interactions of hydrogen storage sites during dehydrogenation warn that some hydrogen if observed in dehydrated mantle-derived samples may not be original and also make hydrogen diffusivity complex.
High throughput downlink cellular packet data access with multiple antennas and multiuser diversity

This paper presents a discussion of MIMO (multiple-input multiple-output) system designed to exploit multiuser diversity, with the principal goal of increasing throughput of delay tolerant data services to nomadic and mobile users in cellular systems. We consider the downlink of a cellular packet data access scheme with a base station transmit antenna array and users equipped with a single receive antenna. We show that it can be preferable to transmit to several users simultaneously using the transmit antenna array even with sub-optimal signaling. This is in contrast to single antenna systems exploiting multiuser diversity and using link adaptation, in which the average throughput per sector is maximized, when in any packet time slot transmission occurs only to one user experiencing the best channel conditions at the time. We propose several scheduling algorithms and compare their performance to the throughput achievable with precoding and perfect channel state information at the transmitter. We show that the capacity scaling typical to MIMO systems can be achieved even with single-antenna mobile receivers, but only a fraction of that capacity can be achieved with limited channel knowledge at the transmitter, when multiuser diversity is exploited.
Auricle Structural Feature for 3D Ear Recognition

The existing local surface representation methods of 3D ear recognition not only ignore the physiological structure of ear, but also have high computation complexity. Aiming at these problems, a novel 3D ear representation called 3D Auricle Structural Feature(3DASF) is proposed. It extracts the auricle structural information by the Surface Variation. 3DASF is used to coarsely align the probe gallery ear pairs, and subsequently ICP fine alignment is performed. The experiments results conducted on the University of Notre Dame(UND) collection J2 dataset outperform the state-of-the-art 3D ear recognition methods based on ICP.
Optimized fishing through periodically harvested closures

Periodically harvested closures are a widespread, centuries-old form of fisheries management that protects fish between pulse harvests and can generate high harvest efficiency by reducing fish wariness of fishing gear. However, the ability for periodic closures to also support high fisheries yields and healthy marine ecosystems is uncertain, despite increased promotion of periodic closures for managing fisheries and conserving ecosystems in the Indo-Pacific. We developed a bioeconomic fisheries model that considers changes in fish wariness, based on empirical field research, and quantified the extent to which periodic closures can simultaneously maximize harvest efficiency, fisheries yield and conservation of fish stocks. We found that periodic closures with a harvest schedule represented by closure for one to a few years between a single pulse harvest event can generate equivalent fisheries yield and stock abundance levels and greater harvest efficiency than achievable under conventional fisheries management with or without a permanent closure. Optimality of periodic closures at maximizing the triple objective of high harvest efficiency, high fisheries yield, and high stock abundance was robust to fish life history traits and to all but extreme levels of overfishing. With moderate overfishing, there emerged a trade-off between periodic closures that maximized harvest efficiency and no-take permanent closures that maximized yield; however, the gain in harvest efficiency outweighed the loss in yield for periodic closures when compared with permanent closures. Only with extreme overfishing, where fishing under nonspatial management would reduce the stock to <= 18% of its unfished level, was the harvest efficiency benefit too small for periodic closures to best meet the triple objective compared with permanent closures. Synthesis and applications. We show that periodically harvested closures can, in most cases, simultaneously maximize harvest efficiency, fisheries yield, and fish stock conservation beyond that achievable by no-take permanent closures or nonspatial management. Our results also provide design guidance, indicating that short closure periods between pulse harvest events are most appropriate for well-managed fisheries or areas with large periodic closures, whereas longer closure periods are more appropriate for small periodic closure areas and overfished systems.
Cellular and widefield imaging of sound frequency organization in primary and higher-order fields of the mouse auditory cortex

The mouse auditory cortex (ACtx) contains two core fields – A1 and AAF – arranged in a mirror reversal tonotopic gradient. The best frequency (BF) organization and naming scheme for additional higher-order fields remain a matter of debate, as does the correspondence between smoothly varying global tonotopy and heterogeneity in local cellular tuning. Here, we performed chronic widefield and 2-photon calcium imaging from the ACtx of awake Thy1-GCaMP6s reporter mice. Data-driven parcellation of widefield maps identified five fields, including a previously unidentified area at the ventral posterior extreme of the ACtx (VPAF) and a tonotopically organized suprarhinal auditory field (SRAF) that extended laterally as far as ectorhinal cortex. Widefield maps were stable over time, where single pixel BFs fluctuated by less than 0.5 octaves during a one-month imaging period. After accounting for neuropil signal and frequency tuning strength, BF organization in neighboring layer 2/3 neurons was intermediate to the heterogeneous salt and pepper organization and the highly precise local organization that have each been described in prior studies. Multiscale imaging data suggest there is no ultrasonic field or secondary auditory cortex in the mouse. Instead, VPAF and a dorsoposterior field (DP) emerged as the strongest candidates for higher-order auditory areas.
Output observer based feedback for soft landing of electromechanical camless valvetrain actuator

Electromechanical valvetrain (EMV) actuators can replace the camshaft allowing for electronically controlled variable valve timing (VVT) on a new generation of engines. Before EMV actuators can be used in production vehicles two critical problems need to be resolved. First, impact velocities between the valve, valve seat, and the actuator itself need to be small to avoid excessive wear on the system and ensure acceptable levels of noise. Second, the opening and closing of the valve needs to be both fast and consistent to avoid collision with the piston and to reduce variability in trapped mass. This paper presents an observer based output feedback controller designed to achieve these goals. Theoretical analysis and experimental results of the controller are provided. The experimental results show a factor of six reduction in impact velocity and consistent and quick valve timing.
INTERACTIVE NEWS FEED EXTRACTION SYSTEM

Our Interactive News Feed Extraction system approach is designed to provide feeds automatically for a given topic on demand of user. It is a dynamic as well as interactive approach that requires no offline data and feeds are generated online only. Thus, it is able to adapt efficiently to the dynamic information space. Interactive News Feed Extraction system is based on peer knowledge that is given by the user online to the system. This system integrates feed from different news sources and users get a relevant set of new feeds on their demand.