Miracle-dz/UniFAR-FTUs huggingface dataset:
Fusing Multiple Sources of Data to Understand Ride-Hailing Use

The rise of ride-hailing services has presented a number of challenges and opportunities in the urban mobility sphere. On the one hand, they allow travelers to summon and pay for a ride through their smartphones while tracking the vehicle’s location. This helps provide mobility for many who are traditionally transportation disadvantaged and not well served by public transit. Given the convenience and pricing of these mobility-on-demand services, their tremendous growth in the past few years is not at all surprising. However, this growth comes with the risk of increased vehicular travel and reduced public transit use, increased congestion, and shifts in mobility patterns which are difficult to predict. Unfortunately, data about ride-hailing service usage are hard to find; service providers typically do not share data and traditional survey data sets include too few trips for these new modes to develop significant behavioral models. As a result, transport planners have been unable to adequately account for these services in their models and forecasting processes. In an effort to better understand the use of these services, this study employs a data fusion process to gain deeper insights about the characteristics of ride-hailing trips and their users. Trip data made publicly available by RideAustin is fused with census and parcel data to infer trip purpose, origin/destination information, and user demographics. The fused data is then used to estimate a model of frequency of ride-hailing trips by multiple purposes.
Optimal Shape Design and its application to microstructures

1. Abstract Previous research has established that a smooth surface has not the minimal drag. As a result of many experiments which have been carried out by different laboratories (e.g. NASA, DLR Berlin) a surface with tiny grooves aligned in the streamwise direction was proposed as a drag reduction device. The aim of this project is to find the optimal shape of such microstructures on surfaces of submerged bodies. We assume that these microstructures remain in the viscous sublayer which is described by the 3D incompressible, steady-state Navier-Stokes equation with a Couette Flow profile. The objective function of our optimization problem is the tangential drag force, which we want to minimize. Solving this problem is difficult because of the oscillating boundary, which causes a big amount of data. We apply Homogenization theory and replace the rough boundary by a smooth artificial one, where the right boundary conditions have been determined. Furthermore, our optimization problem can be simplified using this approximation and we end up minimizing the Navier constant, which depends only on the velocity of an auxiliary boundary layer equation. To solve the optimization problem we consider the sensitivity. From the results obtained here, we are able to derive the necessary optimality condition and to construct a sequence of admissible domains which tends to the optimal solution. We use gradient based optimization methods and the finite element method on unstructured grids for the numerics of state equation. The results obtained with this approach give us a drag reduction of approximately 2-6% relative to the drag of the smooth configuration. 2.
Insertional inactivation of the major autolysin gene of Streptococcus pneumoniae

The lytA gene encoding the major pneumococcal autolysin (N-acetylmuramoyl-L-alanine amidase) was inactivated by inserting the 2-kilobase MspI fragment of pE194 containing the staphylococcal ermC gene. Stable autolysis-deficient (Lyt-) mutants and their isogenic Lyt+ parents were used in experiments designed to test possible physiological functions of the amidase. No autolysis could be induced in the mutants grown at 37 degrees C by deoxycholate, by incubation in stationary phase, or by treatment with penicillin. On the other hand, the Lyt- mutants exhibited normal growth rates and yields and normal adaptive responses during shifts from one growth temperature or nutritional condition to another. There was no evidence for impeded cell separation (chain formation). Colonies of Lyt- insertional mutants produced normal hemolytic zones on blood agar; they showed normal (high) levels of competence for genetic transformation. Lyt- mutants were also able to produce type 3 and 6 capsular polysaccharides, and such strains showed the same degree of virulence in mice as did the isogenic Lyt+ parent. The physiological function(s) of the amidase remains a puzzle.
Technical Efficiency and Rural Poverty Among Farmers in Nigeria : A Gender Perspective By Job

The purpose of this study was to investigate the effect of technical efficiency on rural poverty between female and male-headed farm families in southwestern part of Nigeria. The study also determined the policy variables that influenced technical efficiency of the poor rural female and male-headed households in the study area using the stochastic frontier methodology. Results of data analysis showed that poor male-headed households were more technically efficient than their poor female-headed households’ counterparts (with mean technical efficiency estimates of about 91% and 82% respectively). Policy measures to reduce level of poverty and to improve efficiency which will lead to higher income were then suggested
Search for direct top squark pair production and dark matter production in final states with two leptons in √ s = 13 TeV

The results of a search for new phenomena in events with two leptons (electrons or muons) are reported, using 13.3 fb−1 of integrated luminosity from LHC pp collisions at √ s = 13 TeV collected by the ATLAS detector. Three possible signals are targeted by dedicated selections: the pair production of top squarks decaying via the three body mode t̃1 → χ̃1W b; the pair production of top squarks decaying via t̃1 → χ̃1 b → χ̃1W (∗)b; and the production of dark matter in association with a tt̄ pair. No excess above the Standard Model expectation is observed, and exclusion limits at 95% confidence level are derived for the different models. © 2016 CERN for the benefit of the ATLAS Collaboration. Reproduction of this article or parts of it is allowed as specified in the CC-BY-4.0 license.
Observation of coupled plasmon-polariton modes in Au nanoparticle chain waveguides of different lengths: Estimation of waveguide loss

Near-field interactions between closely spaced Au nanoparticles were characterized by studying the spectral position of the extinction bands corresponding to longitudinal (L) and transverse (T) plasmon-polariton modes of Au nanoparticle chains. Far-field spectroscopy and finite-difference time-domain simulations on arrays of 50 nm diameter Au spheres with an interparticle spacing of 75 nm both show a splitting DeltaE between the L and T modes that increases with chain length and saturates at a length of seven particles at DeltaE = 65 meV. We show that the measured splitting will result in a propagation loss of 3 dB/15 nm for energy transport. Calculations indicate that this loss can be reduced by at least one order of magnitude by modifying the shape of the constituent particles.
Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase

Overexpression of the oncoprotein Aurora A kinase occurs in multiple types of cancer, often early during cell transformation. To identify the mechanism(s) contributing to enhanced Aurora A protein expression, a comparison between normal human lung fibroblast and breast epithelial cells to nontumorigenic breast (MCF10A and MCF12A) and tumorigenic breast (MCF-7) and cervical cell lines (HeLa S3) was performed. A subset of these immortalized lines (MCF10A, MCF12A, and HeLa S3) exhibited increased levels of Aurora A protein, independent of tumorigenicity. The increase in Aurora A protein in these immortalized cells was not due to increased transcription/RNA stability, protein half-life, or cap-dependent translation. Assays utilizing monocistronic and dicistronic RNA constructs revealed that the 5′-leader sequence of Aurora A contains an internal ribosomal entry site (IRES), which is regulated in a cell cycle–dependent manner, peaking in G2/M phase. Moreover, IRES activity was increased in the immortalized cell lines in which Aurora A protein expression was also enhanced. Additional studies indicated that the increased internal initiation is specific to the IRES of Aurora A and may be an early event during cancer progression. These results identify a novel mechanism contributing to Aurora A kinase overexpression. Implications: The current study indicates that Aurora A kinase contributes to immortalization and tumorigenesis. Mol Cancer Res; 11(8); 887–900. ©2013 AACR.
A Technique to Re-Assess Epidemiologic Evidence in Light of the Healthy Worker Effect: The Case of Firefighting and Heart Disease

The healthy worker effect (HWE) is a bias that is believed to have strongly affected the validity of previous cohort mortality studies on the relationship between firefighting and heart disease. There is a strong healthy hired effect (a component of the HWE) among firefighters, owing particularly to the recruitment of nondiabetic candidates. This is shown in previous studies in which the reported standardized mortality ratios for diabetes are much less than unity, generally around 0.3 to 0.5. Because diabetes is known to increase the risk of heart disease, a deficit of diabetes among firefighters is expected to lead to a deficit of heart injury and disease. This would make the cohort mortality studies incapable of detecting any increase in risk of heart injury and disease among firefighters. There is also a strong healthy worker survivor effect (another component of the HWE) among firefighters. In addition, heart disease is a classic example of the HWE because heart disease is chronic and its risk factors can be identified in the selection process. It is believed that (1) a major problem of previous studies on firefighting and heart disease is their failure to recognize the importance of the HWE when interpreting their results, and (2) a technique to re-assess results in light of the HWE is urgently needed. This article addresses the generally accepted principles relating to the HWE, including its definition and sources, and proposes a technique for re-assessing the literature in light of the HWE. The technique was applied to carefully re-assess 23 studies that provided direct evidence for the relationship between firefighting and heart disease. Before the re-assessment, 7 of the 23 studies showed positive evidence and 16 showed no evidence. After the re-assessment, 11 studies showed positive evidence and 12 showed no evidence. Based on the results of the re-assessment of the 23 studies, we concluded that (1) there is strong evidence of an increased risk of death overall from heart disease among firefighters; (2) there is insufficient evidence, even after considering the HWE, that there is an increased risk of death from aortic aneurysm among firefighters; and (3) there is insufficient evidence, even after considering the HWE, for a relationship between firefighting and any heart disease subtype, such as acute myocardial infarction.
Envisioning tangibles and display-rich interfaces for co-located and distributed genomics collaborations

We explore how pervasive displays could offer unique opportunities for enhancing discovery and learning with "big data". In 2012-2014, our collaboration across three universities undertook a series of design exercises investigating approaches for collaborative, interactive, tangibles, and multitouch-engaged visualizations of genomic and related scientific datasets. These exercises led to several envisionments of tangible interfaces that employ active tokens and interactive surfaces to facilitate colocated and distributed engagement with large datasets. We describe some of the motivation and background for these envisioned interfaces; consider key aspects linking and distinguishing the designs; and relate these to the present and near-future state of the art for tangible and multitouch engagement with pervasive displays toward collaborative science.
Une approche centrée sur l'utilisateur pour intégrer les acteurs sociaux dans des communautés d'intérêt

RÉSUMÉ. La détection des communautés d’intérêt est un problème complexe qui a été abordé sous différents angles. Dans ce travail, nous proposons une approche centrée sur l’utilisateur intégrant des profils utilisateurs sociaux dans la détection des communautés dans les réseaux sociaux en ligne. Dans notre approche, nous calculons d’abord l’acquisition explicite des connaissances. En explorant les réseaux égocentriques des utilisateurs, nous pouvons déduire des similitudes implicites des intérêts. Ces similitudes sont estimées en référence à l’homophilie et à l’influence sociale. Cette dernière est utilisée pour améliorer l’analyse des sentiments au sein des communautés. Enfin, nous menons des expériences sur des ensembles de données extraits de réseaux sociaux réels. ABSTRACT. Detecting communities of interest is a complex problem that has been approached from different angles. In this paper, we propose a user-centric approach integrating social user profiles in the detection of communities in online social networks. In our approach, we first compute the explicit acquisition of knowledge. By exploring the egocentric networks of users, we can infer implicit similarities of interests. These similarities are estimated with reference to homophilia and social influence. The latter is used to improve sentiment analysis within communities. Finally, we conduct experiments on data sets taken from real social networks. MOTS-CLÉS. Réseaux Sociaux, Communauté d’intérêt, Profil utilisateur, Ontologie, Analyse des sentiments
Detection and Identification of Hematologic Malignancies and Solid Tumors by an Electrochemical Technique

Purpose Develop and evaluate an electrochemical method to identify healthy individuals, malignant hematopathic patients and solid tumor patients by detecting the leukocytes in whole-blood. Methods A total of 114 individual blood samples obtained from our affiliated hospital in China (June 2015- August 2015) were divided into three groups: healthy individuals (n = 35), hematologic malignancies (n = 41) and solid tumors (n = 38). An electrochemical workstation system was used to measure differential pulse voltammetry due to the different electrochemical behaviors of leukocytes in blood samples. Then, one-way analysis of variance (ANOVA) was applied to analyze the scanning curves and to compare the peak potential and peak current. Results The scanning curve demonstrated the specific electrochemical behaviors of the blank potassium ferricyanide solution and that mixed with blood samples in different groups. Significant differences in mean peak potentials of mixture and shifts (ΔEp (mV)) were observed of the three groups (P< = 0.001). 106.00±9.00 and 3.14±7.48 for Group healthy individuals, 120.90±11.18 and 18.10±8.81 for Group hematologic malignancies, 136.84±11.53 and 32.89±10.50 for Group solid tumors, respectively. In contrast, there were no significant differences in the peak currents and shifts. Conclusions The newly developed method to apply the electrochemical workstation system to identify hematologic malignancies and solid tumors with good sensitivity and specificity might be effective, suggesting a potential utility in clinical application.
Touch or touchless?: evaluating usability of interactive displays for persons with autistic spectrum disorders

Interactive public displays have been exploited and studied for engaging interaction in several previous studies. In this context, applications have been focused on supporting learning or entertainment activities, specifically designed for people with special needs. This includes, for example, those with Autism Spectrum Disorders (ASD). In this paper, we present a comparison study aimed at understanding the difference in terms of usability, effectiveness, and enjoyment perceived by users with ASD between two interaction modalities usually supported by interactive displays: touch-based and touchless gestural interaction. We present the outcomes of a within-subject setup involving 8 ASD users (age 18-25 y.o., IQ 40-60), based on the use of two similar user interfaces, differing only by the interaction modality. We show that touch interaction provides higher usability level and results in more effective actions, although touchless interaction is more effective in terms of enjoyment and engagement.
Youth's Conceptions of Adolescence Predict Longitudinal Changes in Prefrontal Cortex Activation and Risk Taking During Adolescence.

The development of cognitive control during adolescence is paralleled by changes in the function of the lateral prefrontal cortex (PFC). Using a three-wave longitudinal neuroimaging design (N = 22, Mage = 13.08 years at Wave 1), this study examined if youth's stereotypes about teens modulate changes in their neural activation during cognitive control. Participants holding stereotypes of teens as irresponsible in the family context (i.e., ignoring family obligations) in middle school showed increases in bilateral ventrolateral PFC activation during cognitive control over the transition to high school, which was associated with increases in risk taking. These findings provide preliminary evidence that youth's conceptions of adolescence play a role in neural plasticity over this phase of development.
Prediction of Verbal Memory Decline after Epilepsy Surgery in Children: Effectiveness of Wada Memory Asymmetries

Summary: Purpose: Differences in Wada memory performance after left and right amobarbital injection are powerful predictors of pre‐ to postoperative memory change among adult epilepsy patients after anterior temporal lobectomy. It is unknown, however, whether these Wada memory asymmetries apply to children who undergo focal cortical resection or to epilepsy surgery patients who undergo resection outside the temporal lobes.
Forceful closure: cytoskeletal networks in embryonic wound repair

Embryonic tissues heal wounds rapidly and without scarring, in a process conserved across species and driven by collective cell movements. The mechanisms of coordinated cell movement during embryonic wound closure also drive tissue development and cancer metastasis; therefore, embryonic wound repair has received considerable attention as a model of collective cell migration. During wound closure, a supracellular actomyosin cable at the wound edge coordinates cells, while actin-based protrusions contribute to cell crawling and seamless wound healing. Other cytoskeletal networks are reorganized during wound repair: microtubules extend into protrusions and along cell–cell boundaries as cells stretch into damaged regions, septins accumulate at the wound margin, and intermediate filaments become polarized in the cells adjacent to the wound. Thus, diverse cytoskeletal networks work in concert to maintain tissue structure, while also driving and organizing cell movements to promote rapid repair. Understanding the signals that coordinate the dynamics of different cytoskeletal networks, and how adhesions between cells or with the extracellular matrix integrate forces across cells, will be important to elucidate the mechanisms of efficient embryonic wound healing and may have far-reaching implications for developmental and cancer cell biology.
Depression associated with diltiazem.

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Systematic Reviews andMeta- and Pooled Analyses Risk Factors for Bites and Diseases AssociatedWith Black-Legged Ticks: AMeta-Analysis

© The Author(s) 2019. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journalpermissions@oup.com. Vol. 188, No. 9 DOI: 10.1093/aje/kwz130 Advance Access publication: May 30, 2019
An expanded HIV screening strategy in the Emergency Department fails to identify most patients with undiagnosed infection: insights from a blinded serosurvey

ABSTRACT Screening for HIV in Emergency Departments (EDs) is recommended to address the problem of undiagnosed HIV. Serosurveys are an important method for estimating the prevalence of undiagnosed HIV and can provide insight into the effectiveness of an HIV screening strategy. We performed a blinded serosurvey in an ED offering non-targeted HIV screening to determine the proportion of patients with undiagnosed HIV who were diagnosed during their visit. The study was conducted in a high-volume, urban ED and included patients who had blood drawn for clinical purposes and had sufficient remnant specimen to undergo deidentified HIV testing. Among 4752 patients not previously diagnosed with HIV, 1403 (29.5%) were offered HIV screening and 543 (38.7% of those offered) consented. Overall, undiagnosed HIV was present in 12 patients (0.25%): six among those offered screening (0.4%), and six among those not offered screening (0.2%). Among those with undiagnosed HIV, two (16.7%) consented to screening and were diagnosed during their visit. Despite efforts to increase HIV screening, more than 80% of patients with undiagnosed HIV were not tested during their ED visit. Although half of those with undiagnosed HIV were missed because they were not offered screening, the yield was further diminished because a substantial proportion of patients declined screening. To avoid missed opportunities for diagnosis in the ED, strategies to further improve implementation of HIV screening and optimize rates of consent are needed.
Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N‐Methyl‐D‐aspartate receptor or dopamine‐2 receptor

Movement disorder relapses after herpes simplex virus 1 (HSV1) encephalitis have been hypothesized to be secondary to postviral autoimmunity. Recently, a proportion of patients with HSV1 encephalitis (HSE) were shown to produce autoantibodies against N‐methyl‐D‐aspartate receptor (NMDAR).