Miracle-dz/UniFAR-FTUs huggingface dataset:
Natural Convection Enhancement in the Annuli Between Two Homocentric Cylinders by Using Ethylene Glycol / Water Based Titania Nanofluid

The natural convection heat tranfer in annulate region confined between two homocentric cylinders were numerically studied in the present work. The annulus was filled by ethylene glycol / water based Titania nanofluid. Both internal and external cylinders are presereved at an isothermal hot and cold temperatures respectively, whereas, the upper and lower walls are adiabatic. The numerical solution is obtained by applying the finite volume method along with the SIMPLER, and TDMA algorithms. In the current study, the solid volumetric fraction is varied as (0 % ? 3 %), the volume ratios of EG to water are varied as (0:100 %, 40 : 60 %, 100:0 %), while both the Rayleigh number and radii ratio are considered fixed at (Ra = 104 and ? = 2). The obtained results indicated that, the average Nusselt number increases as the solid volumetric fraction and the volume ratio of ethylene glycol in the base fluid increase. Moreover, the velocity profiles reach their maximum value in the half region adjacent the internal hot wall when TiO2 – water nanofluid is used. Also, the temperature profiles decrease along the radial distance for all considered values of volume ratios of EG to water.
Fixed-Time-Convergent Generalized Extended State Observer Based Motor Control Subject to Multiple Disturbances

Inertia load change, torque disturbance, and sophisticated mechanical nonlinearity impose great challenge on the high-precision control design of motor servo systems. To achieve better tracking and disturbance rejection performance, a practical control scheme, which combines a fixed-time-convergent generalized extended state observer (FGESO) with a fixed-time-convergent state feedback control law, is proposed in this article. First, an FGESO is designed to estimate the lumped disturbance and the fixed-time convergence of the estimation errors can be achieved. In the FGESO, there are three parameters and the correction term is selected as a continuous switching function of the output estimation error, which can facilitate the tuning process and greatly alleviate the chattering problem. Second, a control law based on the bilimit homogeneity technique is provided to regulate the tracking errors within a finite time independent of the initial condition. The fixed-time stability of the closed-loop system can be rigorously proved based on the Lyapunov theory. To facilitate the application of the proposed method, a practical two-step tuning procedure is established. Finally, extensive simulations and experiments are performed on a brushless direct current motor to validate the effectiveness and robustness of the proposed method.
In Vitro Efficacy of Clove Oil and Eugenol against Staphylococcus spp and Streptococcus mutans on Hydrophobicity, Hemolysin Production and Biofilms and their Synergy with Antibiotics

The present study aimed to evaluate Syzygium aromaticum (clove) plant extract, clove oil and eugenol for their antibacterial activity and their potential to eradicate bacterial biofilms alone and in combination with antibiotics. Anti-bacterial efficacy of S. aromaticum extract, clove oil and eugenol was evaluated as minimum inhibitory concentration (MIC) and subsequently sub-MICs was selected for inhibition of virulence factors against test bacterial strains. Biofilm cultivation and eradication was assayed using XTT reduction in 96-well microtiter plate. Checkerboard method was used to study the interaction between essential oils and antibiotics. Staphylococcus aureus MTCC3160, Staphylococcus epidermidis MTCC435, Staphylococcus sciuri (SC-01), Staphylococcus auricularis (SU-01) and Streptococcus mutans MTCC497 were found strong biofilm former among all the test bacterial strains. The potency of test agents was found in the order of eugenol > clove oil > S. aromaticum methanolic extract. Sub-MIC (0.5 × MIC) of clove oil and eugenol showed a significant reduction in cell surface hydrophobicity (p S. auricularis (SU-01), S. epidermidis MTCC435 and S. mutans MTCC497 compared to planktonic MIC (PMIC). Antibiotics (vancomycin and azithromycin) exhibited upto 1000-folds increased in SMIC compared to PMIC against all the test bacterial strains. Synergy was observed between eugenol and antibiotics (vancomycin/azithromycin) against all the test bacterial strains in both planktonic and sessile mode. Highest synergy was exhibited between eugenol and azithromycin in planktonic mode (FICI value 0.141). Further, microscopy also confirmed the spectacular effect of combination treatment on pre-formed S. aureus MTCC3160 and S. mutans MTCC497 biofilms. These findings highlighted the promising role of clove oil and eugenol alone and in combination on pathogenic bacterial biofilms.
Direct 12V/24V-to-1V Tri-State Double Step-Down Power Converter With Online VCF Rebalancing and In-Situ Precharge Rate Regulation

In response to fast-growing high-voltage (HV) power IC market demands, this article presents a tri-state double step-down (DSD) power converter to achieve direct 12V/24V- to-1V dc–dc power delivery with high efficiency and high power density. By taking advantage of the benefits from both three-level and DSD converter topologies, the converter allows the use of lower voltage rating power devices and thus facilitates high switching frequency operation with smaller power passives. An online flying capacitor voltage (<inline-formula> <tex-math notation="LaTeX">$V_{\mathrm {CF}}$ </tex-math></inline-formula>) rebalancing scheme is introduced to optimize switching nodes voltages and minimize power path mismatch for improved reliability and efficiency. During startup transients, an <italic>in-situ</italic> precharge rate regulation technique manages the charging process on flying capacitors precisely in avoidance of potential device breakdown. An IC prototype of this design was fabricated using a 180 nm HV bipolar-CMOS-DMOS (BCD) process with an active area die of 6.3 mm<sup>2</sup>. At 3-W output power, a chip power density of 476 mW/mm<sup>2</sup> is accomplished. The online <inline-formula> <tex-math notation="LaTeX">$V_{\mathrm {CF}}$ </tex-math></inline-formula> rebalancing reduces voltage mismatch between the flying capacitors by 16.7%. The converter achieves peak efficiencies of 88.3% and 92.1% for 24V/1V and 12V/1V conversion, respectively.
Clinicopathological Features and Gene Mutation Analysis of Gastrointestinal Stromal Tumors: A Series of 58 Patients

【Background】In gastrointestinal stromal tumors (GISTs), mutually exclusive gain-of-function mutations of KIT and PDGFRA are associated with different mutation-dependent clinical behavior. The study aims to analyze the characteristics of the clinicopathology and genotypes in GISTs in China. 【Methods】All adult patients with GIST located in the stomach or small intestine who underwent surgical resections in the Cancer Hospital, Chinese Academy of Medical Sciences from January 2009 to January 2019 without prior Imatinib(Glivec) treatment were included. Specimens were collected for histopathological examination, and mutations in c-kit and PDGFRα genes were analyzed by PCR and the next generation sequencing(NGS). The clinicopathological characteristics of each gene were also analyzed. 【Results】A total of 58 GIST patients was included in the study. Among the genotypes, there were 51(87.9%) c-kit mutations, five(8.6%) PDGFRα mutations, and two(3.4%) wild-type mutations. Among the cell types, there were 40 cases(69.0%) of spindle cell type, three cases(5.2%) of epithelioid cell type, and three cases(5.2%) of mixed cell type. Among the four mutant forms of c-kit exon-11, the most common were point mutation in 16 cases(38.1%), deletion mutation in 13 cases(31.0%), insertion mutation in four cases(9.5%), and mixed mutation in nine cases(21.4%). According to the National Institutes of Health(NIH) risk grade, there were three cases(5.2%) with very-low risk, nine cases(15.5%) with low risk, 19 cases(32.8%) with medium risk, and 23 cases(39.7%) with high risk. There were significant differences in cell types among different gene types(P = 0.022) and significant differences in tumor risk among different mutant forms of c-kit gene exon-11(P = 0.039). 【Conclusion】In c-kit mutations, spindle cell type was significantly more than epithelioid cell type and mixed cell type. In PDGFRα mutations, spindle cell type and mixed cell type were prevalent. In wild type, spindle cell type and epithelioid cell type were significantly common. A high risk of deletion mutation and mixed mutation is expected in the c-kit exon-11 mutation form, while the intermediate risk of point and insertion mutations are common.
The Analysis of Outcomes of Intracranial Germ Cell Tumors: A Single-institute Study

Purpose: For analyzing the epidemiology and treatment according to the KSPNO protocol results of germ cell tumor patients at our institution.Methods: From 2004 to 2019, of 6494 patients with intracranial neoplasms, 61 (0.9%) patients with iGCTs were enrolled. Pediatric patients underwent chemotherapy and radiotherapy according to the Korean Society for Pediatric Neuro-Oncology (KSPNO) protocol, and adult patients were treated with bleomycin, etoposide, and cisplatin (BEP) regimens. Survival rates, recurrence rates, and posttreatment morbidity were analyzed to identify risk factors. Results: The median age was 20.0 years (range: 1-42), and the follow-up duration was 77.7 months (range: 10.0-203.4 months). The tumors developed most frequently in the pineal gland (49.2%). There were no significant differences in outcomes between protocols, but the KSPNO protocol group had lower tumor recurrence (14.8% vs. 17.6%, p=0.524) and mortality rates (0% vs. 5.9%, p=0.307) than the other groups. According to the pathological subtype, the outcomes were significantly different between the germinoma and nongerminomatous germ cell tumor (NGGCT) groups. The 10-year progression-free survival rates were 93.2% and 67.1% in the germinoma and NGGCT groups, respectively (p = 0.009). The NGGCT pathological type (p=0.021) was a significant recurrence-associated factor in the multivariate analysis. Significant adverse occurred in 14 patients (7 patients in each group). Conclusions: Pure germinomas have a higher survival and lower recurrence rate than NGGCTs. A multidisciplinary approach is needed to select appropriate iGCT treatments, and reducing the radiation dose could minimize posttreatment morbidity.Clinical trial registrationNot applicable
Electrochemical Study of Pyrene on Glassy Carbon Electrode Modified with Metal-Oxide Nanoparticles and Graphene Oxide/Multi-Walled Carbon Nanotubes Nanoplatform

This work describes and compares the electron transport and electrocatalytic properties of chemically synthesised cobalt oxide (Co3O4) and nickel oxide (NiO) nanoparticles grafted onto graphene oxide (GO)/acid treated multi-walled carbon nanotubes decorated glassy carbon electrode. Successful synthesis of these nano materials was confirmed using microscopic and spectroscopic techniques. Successful modification of electrode was confirmed using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Results showed that the GCE-fMWCNT-NiO and GCE-fMWCNT- Co3O4 nanocomposite modified electrodes gave faster electron transfer process in both 5 mM Ferri/Ferro ([Fe(CN)6]3−/4−) redox probe and 0.1 M phosphate buffer solution (PBS). GCE-fMWCNT-NiO and GCE-fMWCNT-Co3O4 electrodes also gave enhanced Pyrene oxidation current compared with bare GCE and other electrodes studied. The charge transfer resistance, electron transfer rate constant (ks), Tafel value, limit of detection (LoD), sensitivity, adsorption equilibrium constant (β), Gibbs free energy change due to the adsorption (ΔGoads) of Pyrene onto the GCE-fMWCNT-Co3O4 are established and discussed. The LoD and ΔGoads for Pyrene were 1.62 nM and -15.8 kJ/mol, respectively, over a linear dynamic range of 1.0 x 10-9 – 100 x 10-9 M. The electro-oxidation of Pyrene was a diffusion dominated process, but demonstrated adsorption thought to be as a result of a combination of the strong pi-pi electron interactions between Pyrene and the MWCNT, thus the thin film formed on the surface of the electrode by the analyte and its reaction intermediates. The LoD compared favourably with literature reported values. GCE-fMWCNT-Co3O4 gave better performance to Pyrene electrooxidation, good resistance to electrode fouling, higher catalytic rate constant and lower limit of detection. The sensor is easy to fabricate, cost effective and could be used for routine determination of Pyrene in food and environmental matrices.
Achieving triple bottom line performance: highlighting the role of social capabilities and environmental management accounting

PurposeThe relationship between the elements of the triple bottom line (TBL) is a controversial area that is constantly debated in the sustainability literature. This study addresses this debate by testing the relationships between these elements, while considering environmental management accounting (EMA) as a mediating influence.Design/methodology/approachThis paper examines survey responses from upper-level managers from ISO 14001-certified manufacturing companies listed on the Indonesian Stock Exchange (IDX). The hypotheses were tested using a partial least squares approach, and bias-corrected and accelerated bootstrap confidence intervals were used to test the significance of the relationships between variables.FindingsThe authors found a direct relationship between the TBL elements and the role of EMA and social performance in mediating the relationship between economic performance and environmental performance.Research limitations/implicationsThis research also provides new insights into the progress of the social resource-based view (SRBV) theory, where the social element missing from the TBL approach can be found.Practical implicationsThe findings of this article imply that it is worthwhile to invest in corporate sustainability because it is thereby possible to simultaneously achieve economic, environmental and social performance, since such elements are truly integrated. In addition, possession of EMA management tools is necessary to enhance the relationships between economic performance and environmental performance. Furthermore, social performance seems to constitute an important bond between both of these, indicating that the social element of the TBL is necessary to achieve truly competitive performance.Originality/valueThis study contributes to the corporate environmental management literature by providing empirical evidence regarding the TBL elements.
Theoretical Screening of Novel 5-picrylamino- 1,2,3,4-tetrazole (PAT) and 5,5′-styphnylamino-1,2,3,4-tetrazole (SAT) Derivatives: A New Molecular Design Strategy of Multi-Nitrogen Energetic Materials by Introducing Intermolecular Hydrogen Bonds and π–π Stacking Interactions

ABSTRACT On the basis of a design strategy that results in the introduction of intramolecular hydrogen-bonds and π–π stacking interactions leading to low-sensitive and high-energy materials (LSHMs), –NH2/–NO2 fused derivatives of 5-picrylamino- 1,2,3,4-tetrazole (PAT) and 5,5′-styphnylamino- 1,2,3,4-tetrazole (SAT) were designed and investigated theoretically. Density functional theory has been explored to investigate the geometric, electronic structures, band gaps, and heats of formation. The detonation performance was evaluated by using Kamlet-Jacobs equations based on the calculated densities and enthalpy of formation (EOF). The thermal stability of these compounds was studied by calculating bond dissociation energies and energy gaps. Proper numbers of 5-aminotetrazole (5-AT) moieties can enhance the EOFs of explosives, further improving the detonation performance as well as nitro group. Though introducing more nitro-groups into TATB frameworks, NH-moieties can retain the intramolecular hydrogen-bond, which can enhance the crystal-packing and physico-chemical stability. Meanwhile, noncovalent interaction (NCI) plots reflects that intermolecular interaction also has a crucial influence on the mechanical sensitivity for the designed derivatives, except for the energy gap (ΔE) and bond dissociation energy (BDE). UV/Vis spectra and 15N isotropic magnetic shielding were further computed for characterizing and predicting the molecular structure and reaction mechanism towards the future experiments. The predicted performance implies that the designed molecules are expected to be promising candidates for multi-nitrogen energetic materials.
Role of Biofield Energy Healing Treatment Based Test Formulation on Colon Cytokines Using TNBS-Induced Ulcerative Colitis in Sprague Dawley Rats

A novel test formulation was formulated and the study aimed to evaluate the therapeutic effect of Biofield Energy Healing (the Trivedi Effect ® -Consciousness Energy Healing) based test formulation on the colon cytokines. Each ingredient of the test formulation was divided into two parts, one part was defined as control and the other part was described group. The level of TNF-α was significantly reduced by 12.2%, 30% ( p< 0.001), 59.1% ( p <0.001), 49.2%, and 15.5% ( p< 0.001) in the G5, G6, G7, G8, and G9 groups, respectively as compared with the G2 group. Further, the level of IFN-γ was significantly decreased by 15.6%, 40.5% ( p< 0.001), 62.1% ( p <0.001), 52.6% ( p< 0.001), and 28.4% by G5, G6, G7, G8, and G9 respectively, as compared with the G2. Besides, IL-10 level was significantly increased by 31.7% ( p <0.001), 14.3%, and 18.7% ( p <0.05) in the G5, G6, and G9 groups, respectively as compared with the G2. Thus, it can be concluded that the Trivedi Effect®-Consciousness Energy Healing significantly modulates the colon cytokines after treatment with the test formulation and Biofield Energy Treatment per se . Thus, the Biofield Energy Treated test formulation can be utilized against many inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis, hepatic, colitis, gastrointestinal, and neurodegenerative along with various other factors such as microbial, parasitic and viral inflammatory responses.
Análisis de los canales de YouTube como influencers del aprendizaje en Educación Primaria

Las redes sociales y los Influencers se han hecho un hueco dentro de la enseñanza. Por consiguiente, el docente tiene que aprovechar estos recursos dentro del ámbito educativo. Por este motivo, se realiza un análisis de contenido de redes sociales de los canales de educación más influyentes de YouTube, observando diversas variables. Se llega a la conclusión de que es fundamental que un docente conozca las potencialidades de estos recursos para emplearlos dentro y fuera del aula.
Mispricing and Uncertainty in International Markets

We develop Residual MisPricing (RMP), an index capturing mispricing relative to a linear benchmark asset pricing model, from the structure imposed by no-arbitrage. RMP is fully conditional and depends only on the returns of basic assets. Return data for several economies reveal that RMP is countercyclical and related to financial uncertainty. RMP further shows a strong positive relation to conditional international equity and currency risk premia, as well as a close link to market-wide funding liquidity shocks. The relations we document hold in particular out-of-sample. Our evidence points to new record highs for RMP during the COVID-19 era, similar to its behavior in the 2008 financial crisis.
Study on Big Order Selling in the Framework of Strategic Marketing Analysis

This paper aimed at researching big order selling. In the past, there were very few researches based on this in China. Therefore, in this paper, relevant literatures will be reviewed again, and theories such as “strategic marketing analysis” and “4Ps”, which were widely used in studying transaction costs and marketing tactics, will be employed to study the big order selling. In addition, research approaches of literature survey, case study, induction and comparative analysis have also been used. Generally speaking, big order selling is quite different from other orders; this paper explores how to successfully complete it. Firstly, this paper analyzes the characteristics, essences, and prerequisites of big order selling. Then, it introduces the theory of strategic marketing analysis. This paper’s author points out that it is critical to build up a sort of adapting organizational structure, which further carries out the principle of relationship marketing and fleshly explains 4P tactics with the four kinds of costs derived from the theory of strategic marketing analysis. This paper also offers some concrete suggestions such as paying more attention to the process, emphasizing demand surveys, attaching importance to two types of costs: information searching cost and moral crises cost, using epilogue skills with caution, and so on. The findings of this study include following standpoints. First, the purpose of big order selling is to offer a systematic solution to thorny problems facing customers. Second, big order sales are typically complex purchases. Customers have high requirements for a company’s prestige. Third, the ultimate total cost borne by customers play s a key role in big order sales. In short, this paper aims to provide some theoretical guidance and reference for those who specialize in big order selling.
The temperature dependence of the helical pitch in a cholesteric liquid crystal

We investigate the temperature dependence of the helical pitch of a cholesteric liquid crystal by means of Monte Carlo simulations. We carry out both lattice and off-lattice simulations to assess the impact of geometric and modelling constraints on the properties of the cholesteric phase. For the off-lattice simulations we develop boundary conditions commensurate with the cholesteric phase and derive an analytic expression for the helical wavenumber q that works well qualitatively. We find that the common simplification of constraining the orientation of the mesogens to planes normal to the helical axis makes q temperature-independent, as predicted by a mean-field theory of van der Meer et al. [J. Chem. Phys. , 3935 (1976)]. However, if mesogens are allowed to rotate in three dimensions, q will increase with temperature, as the isotropic-cholesteric transition is approached from below, in agreement with experiments for a number of substances. Our simulations indicate that the temperature-independent q is merely a consequence of the overly restricted orientational degrees of freedom to points on the unit circle in the model on which the mean-field theory is based. GRAPHICAL ABSTRACT
Alkaline Fractionation and Subsequent Production of Nano-Structured Silica and Cellulose Nano-Fibrils for the Comprehensive Utilization of Rice Husk

The parameters of the alkaline fractionation process were investigated and optimized using a statistical analysis method to simultaneously remove hemicellulose and ash from rice husk (RH) concomitantly. After the alkaline fractionation process, the residual solid contained high cellulose, and the recovery yield of hemicellulose was enhanced in the fractionated liquid hydrolyzate. The hemicellulosic sugar recovery yield (71.6%), de-ashing yield (>99%), and lignin removal (>80%) were obtained at the reaction conditions of 150 °C of temperature, 40 min of reaction time, and 6% (w/v) of NaOH concentration. Subsequently, nano-structured silica was synthesized using black liquor obtained as a by-product of this fractionation process. For the production of nano-structured silica, it was observed that the pH of a black liquor and the heat treatment temperature significantly influenced the textural properties of silica product. In addition, the two-stage bleaching of solid residue followed by colloid milling for the production of high value-added CNF with was attempted. As a result, in addition to 119 g of fermentable sugar, 143 g of high-purity (>98%) silica with a surface area of 328 m2g−1 and 273.1 g of high-functional CNF with cellulose content of 80.1% were simultaneously obtained from 1000 g of RH.