Miracle-dz/UniFAR-FTUs huggingface dataset:
Medical Patients' Experiences of Inreach Occupational Therapy: Continuity between Hospital and Home

Introduction: Reforms in the National Health Service have encouraged a whole system approach. However, coordinated care may be difficult at the interface between acute hospital and community services. Inreach services are community based and the same member of staff provides intervention in hospital and after discharge. This qualitative study aimed to understand medical patients' experiences of inreach occupational therapy. Method: Semi-structured interviews were conducted with a convenience sample of seven older people, following their discharge from a medical inreach occupational therapy service. Thematic analysis was used to explore findings. Findings: Uncertainty was expressed about the role of occupational therapy and about participants not feeling involved in their hospital discharge. There was an appreciation that inreach occupational therapy could aid continuity of care. Some participants considered regular contact with a known health professional to be reassuring on return home, whereas for other participants the principle of accurate information sharing between staff was particularly important at discharge. Conclusion: All participants valued a seamless service between occupational therapy in hospital and at home. The importance of services working across organisational boundaries is emphasised, tailoring the timing of interventions to meet individuals' needs.
The Experience Economy

In 1999, Joseph Pine and James Gilmore offered this idea to readers as a new way to think about connecting with customers and securing their loyalty. As a result, their book "The Experience Economy" is now a classic, embraced by readers and companies worldwide and read in more than a dozen languages. And though the world has changed in many ways since then, the way to a customer's heart has not. In fact, the idea of staging experiences to leave a memorable and lucrative impression is now more relevant than ever. With an ongoing torrent of brands attacking consumers from all sides, how do you make yours stand out? Welcome to the new "Experience Economy". With this fully updated edition of this book, Pine and Gilmore make an even stronger case that experience is the missing link between a company and its potential audience. It offers new rich examples including the U.S. Army, Heineken Experience, Autostadt, Vinopolis, American Girl Place, and others to show fresh approaches to scripting and staging compelling experiences, while staying true to the very real economic conditions of the day.
The Vehicle Routing Problem

The Vehicle Routing Problem covers both exact and heuristic methods developed for the VRP and some of its main variants, emphasizing the practical issues common to VRP. The book is composed of three parts containing contributions from well-known experts. The first part covers basic VRP, known more commonly as capacitated VRP. The second part covers three main variants of VRP with time windows, backhauls, and pickup and delivery. The third part covers issues arising in real-world VRP applications and includes both case studies and references to software packages. The book will be of interest to both researchers and graduate-level students in the communities of operations research and matematical sciences. It focuses on a specific family of problems while offering a complete overview of the effective use of the most important techniques proposed for the solution of hard combinatorial problems. Practitioners will find this book particularly usef
The Natural History of Chronic Bronchitis and Emphysema

The Natural History of Chronic Bronchitis and Emphysema By CHAREES FLETCHER, RICHARD PETO, CECILY TINKER and FRANK E. SPEIZER. Pp. 272, hard cover. Oxford: Oxford University Press, 1976. £9.00. This expensive book is well worth reading. It will be of great interest to all doctors concerned with chronic bronchitis and emphysema. It is written in beautiful English and this makes it a pleasure to read for its own sake and an example to other 'would be' authors. Although condensed into 150 pages (plus 100 pages of references and appendices) it is virtually a 'life work'. The background to the book could hardly be more 'O.K. '. Written by Professor Charles Fletcher and his colleagues, backed by the Medical Research Council, the statistics done by Sir Richard Doll, there is even a note in the 'introduction' to suggest that it is Chapters 1, 5, 6 and 7 which are the most important. The major conclusion of the book is that although other factors may play a role, cigarette smoking was found to be the most important environmental factor in the development of chronic bronchitis and emphysema. Smokers, bombarded with evidence that smoking is bad for their coronary arteries, their peripheral vessels and their stomachs will find nothing here to justify the tobacco smoking which is so harmful to their lungs. Until self-inflicted illness can be charged to the patient, the National Health Service will be responsible for the treatment of chronic bronchitis and emphysema and while this is so, there is unlikely to be a better book than this to guide the NHS or 'Private' doctor.
The Impact of Informational Feedback on Energy Consumption -- A Survey of the Experimental Evidence

In theory, In-Home Displays (IHDs) can revolutionize the way utilities communicate information to customers because they can induce changes in customer behavior even when they are not accompanied by a change in electric prices or rebates for purchasing efficient equipment. IHDs provide consumers with direct feedback—real-time information on energy consumption and costs—and turn a once opaque and static electric bill into a transparent, dynamic, and controllable process. However, to what extent do consumers actually respond to the direct feedback provided by IHDs?
Geological Methods for Evaluation in a Brave New World – Unconventional Reservoir Monitoring

Summary The physics of unconventional reservoir development boils down to two processes – reservoir stimulation during hydraulic fracturing, and fluid recovery during depletion. How these two processes come together and interact with naturally present, pre-existing geological attributes (faults, mineralogy, stresses etc.) to affect well performance is a subject of great interest and fierce debate. At Shell, we have attempted to answer this question by deploying comprehensive instrumented pilot programs that employ various reservoir monitoring technologies including but not limited to microseismic monitoring, chemical tracers, fiber optics, downhole pressure gauges and production logs. These technologies are often implemented in shale gas (SG) and liquid rich shale (LRS) plays to provide insight into the following:  Stimulated Rock Volume produced during completions  Hydraulic fracture half-lengths  Mechanical stratigraphy and geomechanical profiles The above are all important inputs needed to make informed decisions regarding well spacing, well lengths, stage spacing, stage placement, well orientation and well landing – decisions that can challenge or ease the economic feasibility of a project. These data also have the potential to serve as an integrated platform where geologists, geophysicists, production, reservoir and geomechanical engineers can converge to discuss the key uncertainties and issues that affect unconventional reservoir development. However, in order to properly leverage the power of integrated analysis, we must develop novel and innovative workflows that combine existing geological characterization techniques (3D seismic interpretation, core interpretation and analysis, static modeling etc.) with reservoir monitoring and engineering data.
Research on Childhood Obesity Prevention and Intervention

Childhood obesity has more than tripled in the past 30 years. Obesity prevalence among children aged 6 to 11 years increased from 6.5% in 1980 to 19.6% in 2008, and from 5.0% to 18.1% among adolescents aged 12 to 19 (Ogden et al., 2010; National Center for Health Statistics, 2004). Studies continue to link obesity and diet with morbidities such as type 2 diabetes, cardiac disease, stroke, bone and joint problems, sleep apnea, poor self-esteem, and depression (Freedman et al., 2007; U.S. Surgeon General, 2001). As we continue to seek ways to improve the nation’s health status and manage rising healthcare costs, it is imperative that the individual, family, and community take measures to reduce obesity and overweight status. The four research articles profiled here address different aspects of prevention and intervention. The first write-up describes a study investigating an intervention that may be necessary when prevention and lifestyle modification interventions are not available or are not effective— laparoscopic gastric banding surgery for teenagers. The second article describes an investigation into the potential greater risk for obesity in children of single-parent homes. The third and fourth articles discuss different intervention studies—one focused on really early prevention interventions with 0to 5-year-olds and the other on reducing media exposure time as a means of prevention. Interested readers are encouraged to read the articles for full information about the interventions and findings.
Factors affecting the short and long term mortality of infected patients in intensive care unit

Factors affecting the short and long term mortality of infected patients in intensive care unit Ali Kutlucan, Murat Erdoğan, Leyla Kutlucan, Handan Ankaralı, Fatih Ermiş, Mücahit Gür, Elif Şenocak, Hilmi Demirin, Yusuf Aydın 1 Selçuk Üniversitesi Tıp Fakültesi İç Hastalıkları Ana Bilim Dalı, Konya 2 Düzce Üniversitesi Tıp Fakültesi İç Hastalıkları Ana Bilim Dalı, Düzce 3 Konya Eğitim ve Araştırma Hastanesi Anesteziyoloji ve Reanimasyon Kliniği, Konya 4 Düzce Üniversitesi Tıp Fakültesi Biyoistatistik Ve Tıbbi Bilişim Ana Bilim Dalı, Düzce 5 Düzce Üniversitesi Tıp Fakültesi Biyokimya Ana Bilim Dalı, Düzce
Use CT Imaging to Predict the Short-Term Outcome of Concurrent Chemoradiotherapy in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma

Objective: To extract the computed tomography (CT) imaging features of the primary lesions in patients with advanced esophageal squamous cell carcinoma (ESCC) and to study whether these imaging features can predict the short-term outcome after concurrent chemoradiotherapy (CCRT). Methods: From January 2014 to December 2015, a total of 49 patients with locally advanced ESCC who underwent CCRT were analyzed retrospectively. They were randomly categorized into the training and validation groups. Collection of CT imaging of patients before and intermediate stage undergoing radiotherapy. The correlations between imaging characteristics and short-term outcome were analyzed. The accuracy of cutoff value was verified by imaging characteristics of patients in validation group. Result: There were 38 patients in the training group and 11 patients in the validation group. 13 patients in the training group were classified as responders and 25 patients as nonresponders. According to the CT imaging before radiotherapy, there are no significant differences between responders and nonresponders. According to the CT imaging in the middle stage of radiotherapy, responders showed significantly higher Roundness than nonresponders (P = .004, 95% confidence interval [CI] = 0.0419-0.212). The areas under the ROC curves for the ability to predict significantly tumor response were 0.768 for Roundness (P = .001, 95% CI = 0.603-0.889). The cutoff value of Roundness is 0.3099. Roundness showed no significant associations with survival parameters. Conclusions: Computed tomography imaging in the middle stage of radiotherapy can predict the short-term outcome of concurrent chemoradiotherapy for patients with locally advanced ESCC but have no predictive effect on the total survival time.
Application of Radionuclides and Antibody-Drug Conjugates to Target Cancer

Radionuclide therapy and antibody-drug conjugates are used to locate and kill cancer cells by the utilisation of monoclonal antibodies. These bio-vectors are able to transport a cytotoxic drug payload and/or radiation in the form of alpha or beta particles to bind onto antigen specific cancer cells initiating apoptosis. This inaugural article aims to deliver a brief account of these targeted therapies in the treatment of oncological disease states such as leukaemia, non-Hodgkin’s lymphoma, neuroendocrine tumours, breast cancer and prostate cancer bone metastases.
National Diet and Nutrition Survey: fat and fatty acid intakes from the first year of the rolling programme

High fat intakes are an established risk factor for several chronic diseases, such as CVD. In the UK, the Department of Health recommends a maximum intake from total fat of 35%, SFA of 11%, PUFA of 6.5% and trans fat of 2% of daily food energy intake (1) . We report the dietary intakes and main food sources of these nutrients from the ﬁrst year of the National Diet and Nutrition Survey (NDNS) rolling programme, from dietary intake data collected between February 2008 and June 2009 (2) , covering the age range 1.5 years and above. Dietary data were collected in the form of a 4-d estimated food diary, including both weekend days; nutrient intakes were calculated using the dietary assessment system developed at MRC Human Nutrition Research, DINO (Data In Nutrients Out), using the Nutrient Databank of the Food Standards Agency. Results were compared with the Dietary Reference Values (DRV) for the UK (1) and with dietary intake data from the NDNS of Young People (4–18 years) carried out in 1997 (3) and of adults (19–64 years), carried out in 2000–01 (4) . The 7-d intake data from these surveys have been recalculated for 4d to allow direct comparisons. Results showed that total fat provided 34–36% of food energy across all age groups. Intakes were very similar to the previous survey for adults but lower than previous surveys for children. The mean intake for adult women, boys (4–18 years) and younger
Reliability of pFET EEPROM With 70-Å Tunnel Oxide Manufactured in Generic

We investigate the reliability of pFET-based EEP- ROMs with 70-A tunneling oxides fabricated in standard foundry 0.35- m, 0.25- m, and 0.18- m logic CMOS processes. The floating-gate memory cell uses Fowler-Nordheim tunneling erase and impact-ionization generated hot-electron injection for pro- gramming. We show that charge leakage is dominated by the leakage through interlayer dielectrics. We propose a retention model and show the data retention lifetime exceeds 10 years. These results demonstrate the feasibility of producing nonvolatile memory using standard logic processes that have a 70-A oxide. Index Terms—CMOS memory integrated circuits, EPROM, re- liability, reliability model.
Finding One’s Way on the Roads to Social Change

Many theories and models attempt to explain the mechanisms underlying human behavior. In order to maintain an overview of the many aspects involved in communication campaigns, social marketing, and behavior change, the Swiss Federal Office for Public Health has created a metamodel of the impact of its campaigns. This metamodel does not claim to contribute any new findings to behavioral research. Its purpose is primarily to summarize the current state of research in the field in a comprehensive and comprehensible way, with reference to a range of relevant communications, social marketing, and behavior change theories. Dimensions addressed include strategy, processes, and impact, with the final dimension demonstrating the possible ranges of impact from individual to societal and from information to behavior. Social marketers and campaign planners may find this model useful as a planning and evaluation tool for campaigns, programs, or interventions that seek to increase awareness or change behavior. Its focus lies on communication campaigns, while also indicating the limits of campaign efficacy. It makes it clear that campaigns are most effective at the early stages of the behavioral change process, such as capturing attention, while other interventions are more effective at later stages.
AB1254-HPR Decoding the Association of Celiac Disease in Rheumatoid Arthritis Patients Using Clinical Risk Factors

Background Rheumatoid arthritis (RA) is a chronic autoimmune disease, characterized by symmetric erosive synovitis, leading inevitably to the destruction of cartilage and bone as well as bursa and tendon sheaths of joints (1-2). Another ADs is celiac disease (CD) caused by the digestion of gluten in genetically predisposed individuals leading to inflammation and damage in the lining of small intestine (3). Moreover, recent studies have shown that RA patients could suffer from CD (4-5). Objectives In this study, we decode the association of CD in RA patients using key clinical risk factors. Methods Eighty-two RA patients were categorized into RA and RA with CD cohorts based on serum levels of Tissue Transglutaminase (IgA-TTG) autoantibodies. Besides, clinical parameters such as ESR, RF, CRP, MCV, anti-MCV, WBC, FBS, HbA1C, Albumin, Ca2+ and VitD3 were analyzed in healthy volunteers, RA, and RA with CD cohorts respectively. Results Our results showed that RF, CRP, FBS, HbA1C, Anti-MCV, and IgA-TTG concentrations were significantly increased in both RA and RA with CD cohorts than healthy controls. IgA-TTG levels were significantly raised in RA with CD cohorts compared with RA. On the other hand, anti-MCV levels were significantly increased in RA compared to RA with CD group. Besides, both RA and RA with CD cohorts have significantly reduced levels of VitD3 and Albumin in the serum compared with healthy controls. Conclusions Our study shows that RA and RA with CD cohorts have poor glycemic rheostat compared to healthy controls. Higher serum IgA-TTG levels in both RA and RA with CD cohorts indicate the susceptibility of RA patients to develop CD. The reduction in serum VitD3 levels in both RA and RA with CD associates further worsens disease prognosis. Our study, however, provide clue(s) for the differential diagnosis of RA patients with CD and guides in formulating personalized treatment programs for efficient therapeutic outcomes in these patients. References Zeman MN, Scott PJ. Current imaging strategies in rheumatoid arthritis. Am J Nucl Med Mol Imaging 2012;2:174-220. Okada Y, Wu D, Trynka G, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014;506:376-381. Lauret E, Rodrigo L. Celiac disease and autoimmune-associated conditions. Biomed Res Int 2013:127589. Meyer O. Is the celiac disease model relevant to rheumatoid arthritis? Joint Bone Spine 2004;71:4-6. Michelin CM, Aikawa NE, Diniz JC, et al. Association of systemic-onset juvenile idiopathic arthritis and celiac disease - a case report. Acta Reumatol Port 2011;36:404-407 Disclosure of Interest None declared
Setting the stage: The initial immune response to blood-stage parasites

ABSTRACT Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have been elucidated, which complicates vaccine development. Progress has been made in defining the innate signaling pathways activated by parasite components, including DNA, RNA, hemozoin, and phospholipids, which initiate the immune response and will be the focus of this review. The challenge that remains within the field is to understand the role of these early responses in the development of protective adaptive responses that clear iRBC and block merozoite invasion so that optimal vaccines and therapeutics may be produced. Graphical abstract
Evolving phenotypes to endotypes: is precision medicine achievable in asthma?

ABSTRACT Introduction: The development of biologic molecules led to a drastic change in the therapeutic approach to asthma. With the prospect of acting on different pathophysiological mechanisms of the disease, the idea of precision medicine was developed, in which a single molecule is able to modify a specific triggering mechanism. Thus, it seemed limiting to stop at the distinction of patients phenotypes and the concept of endotypes became more relevant in the therapeutic approach. Areas covered: This review deepened the topic of precision medicine through the transition from phenotyping to endotyping. We performed a review of the literature, preferring articles quoted in Medline and published in journals with an impact factor. Results showed that it is fundamental to take into consideration the role of biomarkers and the related therapies currently available for precision medicine. Expert opinion: The possible overlap of patients in different phenotypes requires a more precise classification, which considers endotypization. With the development of biological drugs able to modify and modulate some pathophysiological mechanisms of the disease, the theoretical concept of endotyping becomes practical, allowing the clinician to choose the specific mechanism to ‘attack’ in order to control the disease.
Disparities in Access to Oral Health Care.

In the United States, people are more likely to have poor oral health if they are low-income, uninsured, and/or members of racial/ethnic minority, immigrant, or rural populations who have suboptimal access to quality oral health care. As a result, poor oral health serves as the national symbol of social inequality. There is increasing recognition among those in public health that oral diseases such as dental caries and periodontal disease and general health conditions such as obesity and diabetes are closely linked by sharing common risk factors, including excess sugar consumption and tobacco use, as well as underlying infection and inflammatory pathways. Hence, efforts to integrate oral health and primary health care, incorporate interventions at multiple levels to improve access to and quality of services, and create health care teams that provide patient-centered care in both safety net clinics and community settings may narrow the gaps in access to oral health care across the life course. Expected final online publication date for the Annual Review of Public Health, Volume 41 is April 1, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.