Miracle-dz/UniFAR-FTUs huggingface dataset:
An Ecient Flamelet-based Combustion Model for Supersonic Flows

A combustion model based on a Flamelet/Progress Variable approach for high-speed ows is introduced. In the proposed formulation, the temperature is computed from the transported total energy and tabulated species mass fractions. The combustion is thus modeled by 3 additional scalar equations and a chemistry table that is computed in a pre-processing step. This approach is very ecient and allows the use of complex chemical mechanisms. An approximation is also introduced to eliminate costly iteration steps during the temperature calculation. To better account for compressibility eects, the source term for the progress variable is rescaled with the pressure. The model is tested in both RANS and LES computations of a hydrogen jet in a supersonic transverse ow. Comparison with experimental measurements shows good agreement, particularly in the LES case. It is also found that the disagreement between RANS results and experimental data is mostly due to the mixing model deciencies used in RANS.
Mortality and its Predictors among children on Antiretroviral treatment in Ethiopia: A systematic review and Meta –analysis

Background: It is well known that antiretroviral therapy (ART) decrease the progress of acquired immune deficiency syndrome (AIDS) related morbidity and mortality and helps the progress towards achieving the United Nations Program on HIV/ AIDS(UNAIDS) treatment goals. Despite this, mortality in Ethiopia becomes public health concern, and variance is observed across studies. With this gap, there is no pooled estimate. Thus, the goal of this study was to assess the pooled mortality and its predictors among antiretroviral treated HIV/AIDS patients.Methods: PubMed, Scopus and Google Scholar databases were used to search articles. The quality of studies was assessed using the Newcastle Ottawa quality assessment scale. The funnel plot and Egger's test were performed to confirm the presence of publication bias. Heterogeneity across studies was evaluated using the I2 statistic. The pooled incidence rate and its predictors were estimated using a weighted inverse variance random-effects model. Subgroup analysis and sensitivity analysis were also performed. Results: In this review, 12 studies with the cohort size of 4,935 were included. The overall incidence of mortality rate was 6.02 (95% CI: 3.7, 8.2) per 100 person-years. A higher incidence of mortality was observed (12.51% (95%CI: 0.32, 24.7)) in south nation nationality and Peoples (SNNP) on subgroup analysis. Being advanced world health organization(WHO) clinical stage (AHR:5.34( 95% CI: 3.1,9.2.6)), lower CD4 cell count (AHR :2.46 (95 %CI: 1.8, 3.2)), anemia (AHR :2.76 (95% CI: 1.9,3.9)), and nutritional status (AHR :1.9 (95%CI: 1.3, 2.6)) were major predictors of mortality. In contrast, cotrimoxazole preventive therapy (CPT) (AHR: 0.34, (95% CI 0.05, 0.63)) reduced mortality.Conclusions: In Ethiopia, the incidence of mortality was high. Lower CD4 cell count, anemia, WHO clinical staging (III/IV), and undernutrition were the contributing factors. But cotrimoxazole preventive therapy had a high effect on mortality reduction. Therefore, an earlier management would be started before advancing signs of acquired immune deficiency syndrome (AIDS) regardless of WHO staging, CD4 cell level, and nutritional status.
Parametric Study on Mutual Coupling Reduction for MIMO Future 5G Antennas

— This paper presents the development of a compact Multiple Input Multiple Output (MIMO) antenna using new structure integrated with C shaped parasitic element for mutual coupling reduction and antenna isolation improvement. The antenna has been designed to resonate at 16GHz for future 5G mobile band. The separation of the antennas has been set from 0.5 𝝀 𝟎 to 0.26 𝝀 𝟎 to investigate the mutual coupling between dual antenna elements. The novel C shaped parasitic element has been located around the main radiating patch with 1mm in width to reduce the mutual coupling between the dual element antennas. Meanwhile, the separation distance of 0.32 𝝀 𝟎 between the antennas has been chosen for the final antenna design due to its good performance. By using the novel C shaped parasitic element, the antenna isolation have reduced from -11.77dB for without parasitic condition to -23.92dB when parasitic element was included. The result shows 25.79% isolation improvement has been achieved for antenna with C shaped parasitic element. Furthermore, by introducing the parasitic element, the bandwidth have been improved 32.71% from the design without parasitic element. The antenna was simulated and optimized at 16 GHz using Computer Simulation Technology (CST) with permittivity,  r = 2.2 and thickness, h = 1.57mm on Rogers RT-Duroid 5885 substrate. The antennas are matched at their corresponding frequency of operations. The simulation results have shown that the antenna works
KARAKTERISASI GEN PENYANDI PEDIOSIN PAF-11 PADA Pediococcus acidilactici F-11

Pediocin PaF-11 is a ribosomally synthesized antimicrobial peptide produced by Pediococcus acidilactici F-11. The objectives of this research is to find out the location and the nucleotide sequence of gene, which is involved in the production of pediocin PaF-11. Results showed that the pediocin PaF-11 from the cured cell of P. acidilactici F-11 loss the activity, suggested that the pediocin PaF-11 gene was carried in the plasmid. Agarose gel electrophoresis of P. acidilactici F-11 plasmid DNA with marker I»DNA/HindIII showed that pediocin PaF-11 gene was carried in 12 kb plasmid. Amplification pediocin PaF-11 gene from P. acidilactici F-11 showed that uncured P.acidilactici F-11 culture contain plasmid DNA, indicated by amplification of the papA gene (256 bp). Cured P. acidilactici F-11 culture, plasmid eliminated, indicted by no aplicon DNA detected. This result also suggested that pediocin PaF-11 gene in P. acidilactici F-11 was carried in plasmid. Nucleotide of pediocin PaF-11 encoding gene was sequenced The alignment of that nucleotide sequence showed that pediocin PaF-11 encoding gene have the same sequence with pediocin PA.1 encoding gene in P. acidilactici PAC1.0 and P. acidilactici K10 and pediocin AcH encoding gene in P. acidilactici LB 42-923 and P . parvulus ATO77, and pediocin CP2 in P. acidilactici MTCC 5101.
Far-Infrared Transmittance and Reflectance of YBa2Cu3O7-δ Films on Si Substrates

The transmittance and reflectance of superconductive YBa2Cu3O7-δ (YBCO) thin films deposited on Si substrates have been measured in the far-infrared frequency region from 10 to 100 cm−1 (wavelength from 1000 to 100 μm) at temperatures between 10 and 300 K. The effects of interference, optical resonance, and antireflection on the radiative properties of high-temperature superconducting (HTSC) films are observed and quantitatively analyzed. Furthermore, we have measured the reflectance of the HTSC film-substrate composites for radiation incident on the substrate side (backside reflectance) for the first time. The backside reflectance increases significantly from the normal state to the superconducting state at certain frequencies; this experimentally demonstrates that HTSC films can be used to build far-infrared intensity modulators. The complex refractive index of the YBCO films is determined from the measured transmittance using the Drude model in the normal state and a two-fluid model in the superconducting state. The complex refractive index obtained from this study is useful for various applications of YBCO films, including radiation modulators, detectors, and Fabry-Perot resonators.
Nutrient and microstructural indices of maize and sorghum responses to ammonia pressurization/depressurization

A pressurized ammonia (NH 3 ) technique (TAME) to enhance nutrient availability from maize and sorghum for cattle feeds was investigated. Treatment conditions evaluated were NH 3 loading rate and temperature. Starch, enzyme susceptible starch, in vitro dry matter digestibility (IVDMD), in situ (ISDMD) dry matter digestibility, and structure were determined. Grain treated at 50°C or higher temperatures exhibited popped characteristics and had no intact starch granules. Enzyme susceptible starch was 3.6- and 4.6-fold higher than controls in treated maize and sorghum. The IVDMD increased above control maize (87.8 ± 2.3%) and sorghum (80.0 ± 0.65%) with all NH 3 levels, and it averaged 91.5 ± 1.9% for maize and 87.8 ± 1.0% for sorghum. At 12 and 24 hr, ISDMD was at least 31.8 and 9.3% higher than controls in treated maize, respectively, and 52.9 and 46.6% higher in treated sorghum, respectively. This is the first process to make sorghum more valuable than maize as an energy/protein feedstuff in cattle diets. Because TAME treatment increased ISDMD and rate of digestion, this procedure is expected to increase total nutrient availability from these grains in common beef cattle diets.
Façade detergents as bicelle rim-forming agents for solution NMR spectroscopy

Abstract Out of all membrane mimetics available for solution nuclear magnetic resonance (NMR) spectroscopy, phospholipid bicelles are the most prospective. Unlike lipid-protein nanodiscs their size can be easily controlled over a wide range, and the exchange of matter between the particles can take place. However, recent studies revealed several major drawbacks of conventional 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)/1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) and DMPC/3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS) bicelles. First, size of such bicelles can increase dramatically upon heating, and, second, rim-forming detergents of bicelles can cause improper folding of the water-soluble globular domains of membrane proteins. In order to avoid these effects, we tested the Façade detergents as possible alternative rim-forming agents for small isotropic bicelles. In the present work we characterized the size of bicelles formed by 3α-hydroxy-7α,12α-di-((O-β-D-maltosyl)-2-hydroxyethoxy)-cholane (Façade-EM) and 3α-hydroxy-7α,12α-di-(((2-(trimethylamino)ethyl)phosphoryl)ethyloxy)-cholane Façade-EPC as a function of temperature and lipid/detergent ratio by 1H NMR diffusion spectroscopy. Additionally, the denaturing effects of these two rim-forming agents were investigated using the junction of the transmembrane and intracellular domains of the p75 neurotrophin receptor (p75NTR) as a model object. We show that the use of Façades allows decreasing the temperature-dependent growth of bicelles. The ability of Façade-EM-based bicelles to support the native structure and soluble state of the p75NTR intracellular domain was also revealed.
PHYTOCHEMICAL ANALYSIS OF SECONDARY METABOLITES OF SATUREJA HORTENSIS L.

Objective: The present study was designated to analyse the essential oils and tannins as important secondary metabolites of the aerial part of Satureja hortensis . Methods: The chemical composition of S . hortensis herb was investigated using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS). The essential oil was obtained by hydrodistillation method. Results: The essential oil yield in the aerial part of S . hortensis was 1.61%. GC-MS analysis of the essential oils identified the presence of 29 components. Carvacrol (76.16%), as the main component of essential oils, belongs to the group of aromatic compounds. Eight tannin components identified by HPLC and epigallocatechin (130.91х10 -2 %) are prevalent among them. Conclusion : S. hortensis was found to possess considerable amount of phytoconstituents such as essential oils and tannins. The results of this research will help to study pharmacological properties of the investigated plant and to prevent possible adulteration with other plants.
MCL-1 plays an oncogenic role in breast cancer by modulating chemoresistance and stemness properties by activating Wnt/β-catenin

Background：Breast cancer is the most common malignant tumor and the leading cause of death in women. Chemotherapy is one of the most important treatments for breast cancer. However, the development of chemotherapy resistance is the main cause of 20-30% of breast cancer patients developing metastasis, leading to death. MCL-1, an anti-apoptotic protein, has not been found to contribute to chemotherapy resistance in breast cancer. Methods：We used large gene panels to detect pathological sections of tumors in drug-resistant and sensitive patients. We validated protein profiling by IHC in a larger cohort of samples. We performed the function of MCL-1 by knockdown and overexpression in vitro and in vivo. Luciferase assay and CHIP assay were used to prove the regulatory network between MCL-1 and LRP6.Result:We found that MCL-1 is more highly expressed in drug-resistant breast cancer tissues than it is in sensitive breast cancer tissues. Functional studies have revealed that MCL-1 plays an important role in drug resistance by regulating apoptosis in breast cancer cells. We found that overexpression of MCL-1 enhances the chemoresistance and stemness of breast cancer cells in vitro and in vivo, while silencing has the opposite effect. Mechanistically, by downregulating and upregulating MCL-1, we show that MCL-1 regulates LRP6 and activates the WNT/β-catenin signaling pathway in breast cancer cells. Finally, we found that a high level of MCL-1 expression predicts a poor prognosis in breast cancer. Conclusion:Our work highlights the role of MCL-1 in chemoresistance and stemness. The MCL-1-WNT/β-catenin axis might be used as a new clinical target for breast cancer therapy.
AN EMPIRICAL INVESTIGATION INTO THE RELATIONSHIP BETWEEN PREMIUMS AND CLAIMS PAID IN THE NIGERIAN INSURANCE INDUSTRY: A 2000-2017 ANALYSIS

This study is an investigation into the relationship between premiums received and claims paid in the Nigerian insurance industry over the period 2000-2017. Data on gross premiums received and gross claims paid over the period were gotten from the Central Bank of Nigeria (CBN) statistical bulletin, National Insurance Commission (NAICOM) and the Nigerian Insurers Association (NIA) annual reports. Stationarity test carried out on the data reveal that data is stationary at the 1%, 5% and 10% levels of significance. The cointegration test reveals that no cointegration exists among the variables which imply that there is no long run equilibrium relationship between the variables. Using the ordinary least squares regression, the calculated probability value of 0.167 is higher than the 0.05 significant value, hence we accept the null hypothesis that there is no significant relationship between claims paid and premiums received in the Nigerian insurance industry. The coefficient of determination (R 2 ) of 0.91157 indicates that gross premiums contribute 91.2 percent to variations in gross claims while the remaining 8.6 percent is owing to factors outside the regression model. We therefore conclude that claims paid by insurers is not a function of premiums received and recommend that insurers should endeavour to settle claims promptly and equitably to increase client satisfaction.
Toward developing a metastatic or neoadjuvant breast cancer treatment strategy that incorporates history of response to previous treatments

Background: Information regarding response to past treatments may provide clues concerning the classes of drugs most or least likely to work for a particular metastatic or neoadjuvant early stage breast cancer patient. However, currently there is no systematized knowledge base that would support clinical treatment decision-making that takes response history into account.Methods: To model history-dependent response data we leveraged a published in vitro breast cancer viability dataset (84 cell lines, 90 therapeutic compounds) to calculate the odds ratios (log(OR)) of responding to each drug given knowledge of (intrinsic/prior) response to all other agents. This OR matrix is assuming (1) response is based on intrinsic rather than acquired characteristics, and (2) intrinsic sensitivity remains unchanged at the time of the next decision point. Fisher’s exact test is used to identify predictive pairs and groups of agents (BH p<0.05). Recommendation systems are used to make further drug recommendations based on past ‘history’ of response.Results: Of the 90 compounds, 57 have sensitivity profiles significantly associated with those of at least one other agent, mostly targeted drugs. Nearly all associations are positive, with (intrinsic/prior) sensitivity to one agent predicting sensitivity to others in the same or a related class (OR>1). In vitro conditional response patterns clustered compounds into five predictive classes: (1) DNA damaging agents, (2) Aurora A kinase and cell cycle checkpoint inhibitors; (3) microtubule poisons; (4) HER2/EGFR inhibitors; and (5) PIK3C catalytic subunit inhibitors. The apriori algorithm implementation made further predictions including a directional association between resistance to HER2 inhibition and sensitivity to proteasome inhibitors.Conclusions: Investigating drug sensitivity conditioned on observed sensitivity or resistance to prior drugs may be pivotal in informing clinicians deciding on the next line of breast cancer treatments for patients who have progressed on their current treatment. This study supports a strategy of treating patients with different agents in the same class where sensitivity was previously observed.
Investigation of the association of novel genetic factors on von Willebrand factor (VWF) plasma levels

Background: von Willebrand factor (VWF) is a large multimeric plasma glycoprotein. It plays an important role in haemostasis by promoting platelet adhesion and aggregation at sites of blood vessel damage and by binding to and prolonging the half-life of coagulation factor VIII (FVIII). VWF is synthesised in endothelial cells where it undergoes post-translational modifications including glycosylation and multimerisation. VWF levels vary considerably in the normal population and several factors have been associated with this variation including ABO blood group and age. However, known factors only account for ~65% of variation in level. Previous studies suggest that other genetic loci, including VWF, FUT3 and CLEC4M also influence VWF level. Aims: To identify genetic factors that influence VWF plasma level in the normal population and to investigate the mechanisms by which these genetic factors influence VWF level. Methods: DNA samples and phenotypic data (including VWF levels, age, gender and ABO blood group) were available for ~1100 healthy individuals (HC). Analysis was conducted on VWF, FUT3, FUT5, FUT6 and CLEC4M. In silico analysis was used to identify variants predicted to affect expression or activity. Variants of interest were then genotyped in HC and their association with VWF level was investigated. In vitro studies were used to investigate the effect of these variants on VWF protein and mRNA expression, exon splice enhancer (ESE) motifs, splicing and mRNA half-life. Results: Investigation of 111 single nucleotide variants (SNV) in VWF identified 11 with significant association with VWF plasma level, of which c.2385T>C and c.2365A>G had been reported in previous studies. In vitro analysis showed that both were associated with increased protein, mRNA level and mRNA half-life. Investigation of variants in FUT3, FUT5 and FUT6 showed that only FUT3 c.202T>C was significantly associated with VWF plasma level. Investigation of CLEC4M confirmed the association of a 23 amino acid variable number of tandem repeats (VNTR) with VWF plasma level. Conclusion: Variants within and outside VWF are found to be significantly associated with VWF plasma level through interfering with protein or mRNA levels. These factors were shown to have an additive effect and can be considered as risk factors for bleeding or cardiovascular disease.
Preparation and Antibacterial Activity of Inclusion Complex Sulfonatocalix[4]arene-Xanthone against Escherichia Coli

The preparation of inclusion complex sulfonatocalix[4]arene (SC[4]A) with xanthone and measurement of antibacterial activity against Escherichia coli have been performed. Analysis of the structure of inclusion complex between SC[4]A and xanthone was investigated by using Fourier Transform Infrared Spectroscopy (FT-IR) and H Nuclear Magnetic Resonance (H-NMR). The solubility of the product in water was examined. Surface area and porous determination were analyzed by Surface Area Analyzer (SAA). Antibacterial activity test was performed for 0, 3, 6, 9, 12, and 24 hours. The results showed that antibacterial activity of the complex of xanthone SC[4]An against Escherichia coli was higher than that of xanthone it self.
Evaluasi aktivitas anti mikobakterium tanaman obat Indonesia dengan pengujian reduksi resazurin

Abstrak. Sari M, Kusharyoto W. 2016. Evaluasi aktivitas anti mikobakterium tanaman obat Indonesia dengan pengujian reduksi resazurin. Pros Sem Nas Masy Biodiv Indon 2: 138-142. Tuberkulosis (TB) merupakan salah satu penyakit paling berbahaya yang menular dan disebabkan oleh bakteri patogen tunggal. Tuberkulosis menginfeksi baik individu sehat maupun individu dengan daya tahan tubuh lemah. Produk alami yang berasal dari mikroba dan tanaman obat merupakan sumber yang sangat penting untuk pengobatan TB. Pengujian reduksi resazurin menggunakan pelat mikro (MRA) umum digunakan dalam mengevaluasi produk alami dan senyawa sintetis sebagai aktivitas anti-mikobakterium. Penelitian ini menggunakan metode MRA dan bertujuan untuk mengevaluasi aktivitas anti-mikobakterium dari ekstrak kimia tanaman terhadap Mycobacterium smegmatis dan M. bovis BCG serta membandingkannya dengan obat anti-mikobakterium Rifampisin. MRA dioptimalkan dengan menggunakan 2% pelarut DMSO dan larutan indikator 62,5 μg/ml resazurin dalam 5% larutan tween 80 selama 96 jam inkubasi. Ekstrak metanol tanaman yang didapat dari berbagai tanaman obat Indonesia telah diketahui secara empiris memiliki aktivitas anti-mikobakterium, mencakup Baeckea frutescens (Myrtaceae), Caesalpinia sappan (Fabaceae), Centella asiatica (Apiaceae), Ficus deltoidea (Moraceae), Merremia mammosa (Convolvulaceae), Pluchea indica (Asteraceae), Sida rhombifolia (Malvaceae), Tinospora crispa (Menispermaceae), Usnea barbata (Parmeliaceae), dan Zingiber aromaticum (Zingiberaceae). Hasil menunjukkan bahwa ekstrak S. rhombifolia dan L. lavandufolia memiliki potensi aktivitas menghambat M. smegmatis, begitu juga ekstrak F. deltoidea dan B. frustecens memiliki aktivitas sebagai anti M. bovis, dan ekstrak Z. aromaticum memiliki aktivitas anti-mikobakterium pada kedua bakteri (M. smegmatis M. bovis). Aplikasi MRA menggunakan bakteri uji M. smegmatis atau M. bovis BCG sebagai target anti-mikobakterium memiliki beberapa kelebihan diantaranya biaya rendah, pengujian cepat, dan pengujian yang aman untuk aktivitas anti-mikobakterium dalam format uji cepat berteknologi tinggi.
KESULITAN KEUANGAN: PENGARUH STRUKTUR KEPEMILIKAN

Abstract: This study aimed to prove that the ownership structure has a significant and negative effect on the level of financial distress. Indicators of ownership structure are ownership concentration, managerial, institutional, and family ownership. The purposive sampling method was used in selecting 95 manufacturing companies listed on the Indonesia Stock Exchange during 2013-2017. Data was analyzed by panel regression method. The results showed that only foreign ownership has a negative and significant effect on the financial distress. The managerial and institutional ownership have significant and positive effect on financial distress, while concentration of ownership has no influence. These evidence shows that the large percentage of managerial, institutional and concentrated ownership could not decrease the level of financial difficulties. It occurred because the shareholders were less reliable in the supervision and control, hence the decisions taken by manager were not accurate.