Miracle-dz/UniFAR-FTUs huggingface dataset:
Endothelin as a final common pathway in the pathophysiology of preeclampsia: therapeutic implications

Purpose of reviewPreeclampsia remains a major health concern in the United States and worldwide. Recent research has begun to shed light on the underlying mechanisms responsible for the symptoms of preeclampsia, and may provide new avenues for therapy for the preeclamptic patient. Recent findingsThe central role of placental ischemia in the manifestation of preeclampsia has provided new understanding for the origin of pathogenic factors in the preeclamptic patient. The release of soluble factors into the maternal bloodstream from the ischemic placenta is now recognized as a central mechanism in disease manifestation. Specifically, the importance of the vascular endothelial growth factor antagonist soluble fms-like tyrosine kinase and immune factors as factors regulating maternal endothelial dysfunction has become widely acknowledged. Furthermore, mounting evidence implicates the signaling protein endothelin-1 as the final converging factor in the multifaceted cascades that are responsible for the symptomatic manifestation of preeclampsia. Endothelin-1, as a final common pathway in the pathogenic cascade of preeclampsia, presents an intriguing new therapeutic approach for preeclamptic patients. SummaryIdentification of antiangiogenic, autoimmune, and inflammatory factors produced in response to placental ischemia have provided potential new avenues for future research into novel therapies for the preeclamptic patient, and suggest new therapeutic avenues for the treatment of preeclampsia.
Mode of Migration, Age at Arrival, and Occupational Attainment of Immigrants from Mainland China to Hong Kong

Abstract This paper examines occupational attainment of Chinese immigrants in Hong Kong by comparing immigrants from Guangdong province with people who stayed in Guangdong and Hong Kong natives. Taking advantage of comparable data from the Hong Kong Panel Study of Social Dynamics (HKPSSD) and the China Family Panel Studies (CFPS), we find that Chinese immigrants have significantly lower occupational attainment, measured by International Socioeconomic Index (ISEI), than their counterparts in both the origin and the destination. We further examine whether immigrants’ occupational attainment differs by mode of migration and age at arrival. Results show that disadvantages exist for documented immigrants and those who arrived in Hong Kong at age 13 or older, whereas undocumented immigrants and those who arrived younger than 13 do not differ significantly from either Guangdong stayers or Hong Kong natives.
Do diasporas affect regional knowledge transfer within host countries? A panel analysis of German R&D collaborations

ABSTRACT Interactive regional learning involving various actors is considered a precondition for successful innovations and, hence, for regional development. Diasporas as non-native ethnic groups are regarded as beneficial since they enrich the creative class by broadening the cultural base and introducing new routines. Using data on research and development (R&D) collaboration projects, the analysis provides tentative evidence that the size of diasporas positively affects the region’s share of outward R&D linkages enabling the exchange of knowledge. The empirical analysis further confirms that these interactions mainly occur between regions hosting the same diasporas, pointing to a positive effect of ethnic proximity rather than ethnic diversity.
Epoprostenol infusion therapy changes angiographic findings of pulmonary arteries in patients with idiopathic pulmonary arterial hypertension.

BACKGROUND The pulmonary vascular changes induced by epoprostenol in patients with idiopathic pulmonary artery hypertension (IPAH) have not been reported by a clinical study. METHODS AND RESULTS Analysis 1 compared the wedged pulmonary angiography (PAG) findings prior to initiation of epoprostenol therapy (n=24) with those after initiation (n=16). Analysis 2 compared the PAG findings prior to and after initiation of epoprostenol therapy (n=9) in the same pulmonary arteries in the same subjects. In analysis 1, a "cotton grass-like" stain originating from the peripheral pulmonary vessels (each vessel could not be distinguished on angiography) was not observable in any of 24 cases before initiation of epoprostenol therapy, but was visible in 13 of 16 cases after (p<0.0001). In analysis 2, the diameter of subsegmental arteries changed from 3.0+/-0.9 mm (mean +/- standard deviation) to 3.7+/-1.2 mm (p=0.004) between the 2 time periods. Cotton grass-like stain was not found in any cases before epoprostenol, but in all 9 cases after chronic use (p=0.004). CONCLUSIONS After initiating epoprostenol therapy, cotton grass-like stain appeared in most patients with IPAH. The possible reason for this is release of severe vasoconstriction and/or emergence of neovascularization.
Policy Recommendations for Meeting the Grand Challenge to Eradicate Social Isolation (Policy Brief No. 5)

Social isolation is a potent killer. Public health experts now posit that the association between social isolation and health is as strong as the epidemiological evidence that linked smoking and health at the time U.S. Surgeon General C. Everett Koop issued his now-famous warning.1 Thus, it is time to strategically identify social policies that, if enacted, would greatly reduce the incidence of social isolation.
Role of Thyroid Hormone and Nerve Growth Factor in the Development of Choline Acetyltransferase and Other Cell‐Specific Marker Enzymes in the Basal Forebrain of the Rat

The effects of treatment with l‐thyroxine (subcu‐taneously 0.3 μg/g body weight daily from birth, i.e., day 1) and 2.5S nerve growth factor (NGF; intraventricularly 2 μg on 1, 3, 5, 7, and 9 postnatal days), separately and together, were studied on the biochemical development of different cell types in the basal forebrain of 10‐day‐old rats. The development of cholinergic, γ‐aminobutyric acid‐ergic (GABAergic), and glutamatergic neurons was monitored respectively in terms of choline acetyltransferase (ChAT), glutamate decarboxylase (GAD), and glutaminase activities, whereas glutamine synthetase (GS) and 2′,3′‐cyclic nu‐cleotide‐3′‐phosphohydrolase (CNPase) activities were used to judge the maturation of astroglial and oligodendroglial cells. Treatment with either thyroid hormone or NGF from birth significantly increased the expression of ChAT activity in the basal forebrain of neonatal rats. When both agents were administered to the same animal, in agreement with our earlier in vitro findings, the stimulation in ChAT activity was much greater than the sum of the individual effects. In hypothyroid rats, significant effects of NGF at the low doses used were not detectable, although the increase of ChAT activity induced by thyroxine was potentiated by NGF in these animals. Under the present experimental conditions neither thyroxine nor NGF treatment had an appreciable effect on the activities of glutaminase, GS, and lactate dehydrogenase. However, the administration of thyroxine markedly increased CNPase activity in normal rats, whereas in hypothyroid rats the effect on both CNPase and GAD was also significant. Similar elevations in CNPase and GAD activities were not observed after NGF treatment, suggesting that the effect of NGF was specific to the cholinergic cells. The observations provide further support for our proposal that subcortical cholinergic neurons are subject to regulation by an interaction between thyroid hormone and local humoural factors such as NGF.
On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development

The ABC model of flower development explains how three classes of homeotic genes confer identity to the four types of floral organs. In Arabidopsis thaliana, APETALA2 (AP2) and AGAMOUS (AG) represent A- and C-class genes that act in an antagonistic fashion to specify perianth and reproductive organs, respectively. An apparent paradox was the finding that AP2 mRNA is supposedly uniformly distributed throughout young floral primordia. Although miR172 has a role in preventing AP2 protein accumulation, miR172 was reported to disappear from the periphery only several days after AG activation in the center of the flower. Here, we resolve the enigmatic behavior of AP2 and its negative regulator miR172 through careful expression analyses. We find that AP2 mRNA accumulates predominantly in the outer floral whorls, as expected for an A-class homeotic gene. Its pattern overlaps only transiently with that of miR172, which we find to be restricted to the center of young floral primordia from early stages on. MiR172 also accumulates in the shoot meristem upon floral induction, compatible with its known role in regulating AP2-related genes with a role in flowering. Furthermore, we show that AP2 can cause striking organ proliferation defects that are not limited to the center of the floral meristem, where its antagonist AG is required for terminating stem cell proliferation. Moreover, AP2 never expands uniformly into the center of ag mutant flowers, while miR172 is largely unaffected by loss of AG activity. We present a model in which the decision whether stamens or petals develop is based on the balance between AP2 and AG activities, rather than the two being mutually exclusive.
Fusing different levels of deep features by deep stacked neural network for hyperspectral images

Deep learning techniques have been demonstrated to be a powerful tool to learn features of images automatically. In this paper, a novel deep learning structure, i.e., deep stacked neural network (DSNN), is constructed to extract different levels of deep features of hyperspectral images. Specifically, convolutional neural network (CNN) is used as basic units in the proposed DSNN for feature extraction of hyperspectral images. Then, different levels of deep features are concatenated to form a novel fused feature for classification with a typical classifier, e.g., SVM. Experimental results on two benchmark hyperspectral datasets show that the fusion of features extracted in DSNN can produce higher classification accuracy than state-of-the-art deep learning based methods, indicating its effectiveness in feature learning.
Facilitating Action Learning: A Practitioner's Guide

This is really going to save you time and your money in something should think about. If you're seeking then search around for online. Without a doubt there are several these available and a lot of them have the freedom. However no doubt you receive what you spend on. An alternate way to get ideas would be to check another facilitating action learning a practitioners guide. Searching for certified reading sources? We have facilitating action learning a practitioners guide to check out, not just read, however additionally download them or even review online. Find this wonderful publication writtern by by now, simply below, yeah just below. Get the documents in the types of txt, zip, kindle, word, ppt, pdf, as well as rar. Once more, never miss out on to check out online as well as download this book in our site right here. Click the web link. Need a great e-book? facilitating action learning a practitioners guide by , the best one! Wan na get it? Locate this superb electronic book by right here now. Download or check out online is offered. Why we are the most effective website for downloading this facilitating action learning a practitioners guide Naturally, you could pick the book in numerous data types and also media. Seek ppt, txt, pdf, word, rar, zip, as well as kindle? Why not? Get them right here, now! GO TO THE TECHNICAL WRITING FOR AN EXPANDED TYPE OF THIS FACILITATING ACTION LEARNING A PRACTITIONERS GUIDE, ALONG WITH A CORRECTLY FORMATTED VERSION OF THE INSTANCE MANUAL PAGE ABOVE.
The constraints of Chinese tourists to visit Korea caused by THAAD using Q-methodology

ABSTRACT The recent deployment of the THAAD system to South Korea has resulted in complex and controversial issues, particularly in the political, diplomatic, and economic relations between Korea and China [Perlez, J. (2017, May 31). China woos South Korea’s new leader, but the U.S. left behind a spoiler. The New York Times. Retrieved from https://www.nytimes. com/2017/05/31/world/asia/china-south-korea-xi-jinping-moon-jaein-thaad.html? _r=0]. To minimize its negative impact on international tourism, the underlying psychological mechanisms of Chinese tourists associated with this complex political issue should be determined. As an attempt to resolve the current crisis, this study identified the subjective characteristics of Chinese tourists who cancelled visits to Korea using Q-methodology and classified Chinese tourists’ attitude towards the THAAD issue. Based on respondent’s evaluations on Q-sample statements, four types of Chinese tourists were articulated, namely, patriotism, risk awareness, external dependency, and Lotte sanctions. By delving into tourists’ subjectivity, Q-methodology seems powerful to elicit intrapersonal constraints, which are deeply embedded in an individual’s psychological state. The results showed that the THAAD issue greatly influenced Chinese tourists’ personal values, beliefs, and identities.
Pedestrian near-miss analysis on vehicle-mounted driving recorders

Recently, a demand for video analysis on vehicle-mounted driving recorders has been increasing in vision-based safety systems, such as for autonomous vehicles. The technology must be positioned one of the most important task, however, the conventional traffic datasets (e.g. KITTI, Caltech Pedestrian) are not included any dangerous scenes (near-miss scenes), even though the objective of a safety system is to avoid danger. In this paper, (i) we create a pedestrian near-miss dataset on vehicle-mounted driving recorders and (ii) propose a method to jointly learns to predict pedestrian detection and its danger level {high, low, no-danger} with convolutional neural networks (CNN) based on the ResNets. According to the result, we demonstrate the effectiveness of our approach that achieved 68% accuracy of joint pedestrian detection and danger label prediction, and 58.6fps processing time on the self-collected pedestrian near-miss dataset.
Transforming Potential of the Adenovirus Type 5 E4orf3 Protein

ABSTRACT Previous observations that the adenovirus type 5 (Ad5) E4orf6 and E4orf3 gene products have redundant effects in viral lytic infection together with the recent findings that E4orf6 possesses transforming potential prompted us to investigate the effect of E4orf3 expression on the transformation of primary rat cells in combination with adenovirus E1 oncogene products. Our results demonstrate for the first time that E4orf3 can cooperate with adenovirus E1A and E1A plus E1B proteins to transform primary baby rat kidney cells, acting synergistically with E4orf6 in the presence of E1B gene products. Transformed rat cells expressing E4orf3 exhibit morphological alterations, higher growth rates and saturation densities, and increased tumorigenicity compared with transformants expressing E1 proteins only. Consistent with previous results for adenovirus-infected cells, the E4orf3 protein is immunologically restricted to discrete nuclear structures known as PML oncogenic domains (PODs) in transformed rat cells. As opposed to E4orf6, the ability of E4orf3 to promote oncogenic cell growth is probably not linked to a modulation of p53 functions and stability. Instead, our results indicate that the transforming activities of E4orf3 are due to combinatorial effects that involve the binding to the adenovirus 55-kDa E1B protein and the colocalization with PODs independent from interactions with the PML gene product. These data fit well with a model in which the reorganization of PODs may trigger a cascade of processes that cause uncontrolled cell proliferation and neoplastic growth. In sum, our results provide strong evidence for the idea that interactions with PODs by viral proteins are linked to oncogenic transformation.
Influence of users’ psychosocial traits on Facebook travel–related behavior patterns

The principal aim of the article was to explore the psychological aspects of Facebook (FB) users’ travel-related behavior on FB. This especially refers to the time they post their travel-related information, the type of information they post (photos, videos, comments, etc.), when they watch the photos of other people, are they keen to post the information when their impressions are positive or negative, and what level of privacy they keep (with whom they are sharing travel-related information). A total of 804 general FB users from Serbia were included in the study. Analysis of the relationship between travel-related behavior on FB and the different psychosocial aspects of FB use (PSAFU) can be of great importance for online destination marketing. This could help in identifying the patterns of tourists’ FB behavior that result in sharing their travel experiences via electronic word-of-mouth as well as in predicting the FB behavior of future tourists. The study revealed that all analyzed dimensions of PSAFU are related to certain travel-related behavior on FB, explained from 1.9% to 13.7% of these behaviors. The strongest and most consistent predictor of travel-related FB behaviors was ‘Virtual self’ dimension. On contrary, the study showed that Compensatory use of FB is not related to travel-related behavior on FB to a great extent, thus is not of much interest to destination marketers. The further implications are discussed in the article.
Does Welfare Play Any Role in Female Headship Decisions

During the 30 years, the composition of white and black families in the US has changed dramatically. In 1960, less than 10% of families with children were headed by a single mother, while in 1990 more than 20% of families with children were headed by females. A large body of research has focused on the role of the U.S. welfare system and particularly of the Aid to Families with Dependent Children (AFDC) program, in contributing to these changes in family structure. Most studies use cross-sectional data and identify the effect of welfare on female headship through interstate variation in the AFDC program. Recent research finds that controlling for state effects has a large impact on the estimated welfare effect. This paper examines why state effects matter for estimating the role of welfare in female headship decisions by examining the of individual effects and policy endogeneity. An explanation for why state effects matter is that the composition of the population across the states differs, and the composition is related to the generosity of the state's welfare program. If that is true, then controlling for individual effects should have the same result as controlling for state effects. We also examine the endogeneity of AFDC policy by including controls representing the determinants of state welfare generosity. The results show that after controlling for individual effects, there is no evidence that welfare contributes to increasing propensities to form female headed households for either whites or blacks. Further, the results suggest that welfare-induced migration among blacks leads to an upward bias in the estimated welfare effect in previous studies.
Androgens and bone

Purpose of reviewThe present review will focus on the most important recent findings with respect to skeletal androgen action. Many studies have indicated that part of the androgen action may be related to the conversion of androgens into estrogens. Therefore, some of the most recent findings of skeletal estrogen action relevant for male skeletal physiology will also be discussed. Recent findingsAndrogens and estrogens stimulate bone formation and inhibit bone resorption. Sex steroids may interact with different receptors, target cells and other bone anabolic pathways. Androgen receptor and estrogen receptor signalling appear to be important for male bone formation during growth. Sex steroid signalling may involve genomic and nongenomic pathways, interaction with mechanical loading, the growth hormone/insulin-like growth factor-I axis and/or other bone anabolic pathways. Estrogen receptor α in osteoclasts appears to regulate bone resorption in women but not men, whereas androgen receptor signalling in osteoblasts may only partly regulate bone resorption in males. SummaryThe latest developments indicate that androgens and estrogens are important for male bone metabolism and homeostasis and therefore selective estrogen receptor α and androgen receptor signalling remain interesting drug targets for the stimulation of bone formation and male skeletal integrity.
La cooperación tecnológica universidad-empresa: el rol de la comunicación

El trabajo aborda la cooperacion tecnologica entre universidad y empresa bajo el enfoque de redes, discutiendo la importancia del comportamiento de comunicacion. Se analiza como la comunicacion se relaciona con el exito de la transferencia de conocimiento y si existen diferencias en la relacion entre ambas variables en funcion de la modalidad bajo la que se desarrolla la cooperacion. La aplicacion empirica en Espana evidencia que una comunicacion adecuada, oportuna, completa y creible entre los miembros de la empresa y del equipo de investigacion universitario se asocia positivamente con el exito de la transferencia de conocimiento. Ademas, cuando el acuerdo se desarrolla bajo la forma de investigacion cooperativa, se observa una mayor asociacion entre el comportamiento de comunicacion y el exito de la transferencia de conocimiento. Asi, se deriva la necesidad de que directivos e investigadores participantes en acuerdos de cooperacion presten especial atencion a la comunicacion interorganizativa e intraorganizativa.
Flowers of Evil? Industrial Development and Long-Run Prosperity

This research explores the effect of industrialization on the process of development. In contrast to conventional wisdom that views industrial development as a catalyst for economic growth, the study establishes that while the adoption of industrial technology was conducive to economic development in the short-run, it has detrimental effects on the standard of living in the long-run. Exploiting exogenous geographic and climatic sources of variation in the diffusion and adoption of steam engines across French departments during the early phases of industrialization, the research establishes that intensive industrialization in the middle of the 19th century increased income per capita in the subsequent decades but diminished it by the turn of the 21st century. The analysis further suggests that the adverse effect of earlier industrialization on long-run prosperity can be attributed to the negative impact of the adoption of unskilled-intensive technologies in the early stages of industrialization on the long-run level of human capital and thus on the incentive to adopt skill-intensive technologies in the contemporary era. Preferences and educational choices of second generation migrants within France indicate that industrialization has triggered a dual techno-cultural lock-in characterized by a reinforcing interaction between technological inertia, reflected by the persistence predominance of low-skilled-intensive industries, and cultural inertia, in the form of a lower predisposition towards investment in human capital. These findings suggest that the characteristics that permitted the onset of industrialization, rather than the adoption of industrial technology per se, have been the source of prosperity among the currently developed economies that experienced an early industrialization. Thus, developing economies may benefit from the allocation of resources towards human capital formation and skilled intensive sectors rather than toward the promotion of traditional unskilled-intensive industrial sectors.