Miracle-dz/UniFAR-FTUs huggingface dataset:
Intravenous DOPG liposomes do not augment pH gradient liposome supported peritoneal dialysis in treatment of acute intravenous amitriptyline intoxication in rats

Abstract Introduction: Liposomes are nanospheres of lipid bilayer which can bind drug either in the phospholipid membrane or in the central aqueous droplet. Liposomes loaded with a drug can facilitate drug delivery, and empty liposomes can sequester certain drugs to reduce aqueous drug concentrations in experimental intoxication. Therapeutic dialysis in intoxication is limited by drug volumes of distribution and blood protein binding. In rats intoxicated with intravenous amitriptyline, we examined adding intravenous membrane-binding 1,2-dioleoyl-sn-glycero-3-phosphoglycerol (DOPG) liposomes to liposome supported peritoneal dialysis (LSPD) in which liposomes in dialysate were augmented with an acidic core. The hypothesis was that a “gradient of liposome affinity” would increase LSPD amitriptyline concentrations. Methods: Seven control and five intravenous DOPG liposome pre-treated rats were injected with amitriptyline, followed 10 min later by a 10-min LSPD dwell. Results: DOPG liposomes increased blood amitriptyline concentrations by 50%; control (median [IQR] 1250 [951–1356] nmol/L; intravenous DOPG 1702 [1602–1864] nmol/L, p = 0.032). However, there was no corresponding increase in LSPD dialysate amitriptyline concentrations at the end of the dwell; control (median [IQR] 430 [334–2180] nmol/l, intravenous DOPG 414 [387–483] nmol/L p = 0.75). Conclusions: Pre-treatment with DOPG liposomes decreased amitriptyline volume of distribution but had no significant effect on elimination of amitriptyline by LSPD.
Deterministic Data Distribution for Efficient Recovery in Erasure-Coded Storage Systems

Due to individual unreliable commodity components, failures are common in large-scale distributed storage systems. Erasure codes are widely deployed in practical storage systems to provide fault tolerance with low storage overhead. However, random data distribution (RDD), commonly used in erasure-coded storage systems, induces heavy cross-rack traffic, load imbalance, and random access, which adversely affects failure recovery. In this article, with orthogonal arrays, we define a Deterministic Data Distribution (<inline-formula><tex-math notation="LaTeX">$D^3$</tex-math><alternatives><mml:math><mml:msup><mml:mi>D</mml:mi><mml:mn>3</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="xu-ieq1-2987837.gif"/></alternatives></inline-formula>) to uniformly distribute data/parity blocks among nodes, and propose an efficient failure recovery approach based on <inline-formula><tex-math notation="LaTeX">$D^3$</tex-math><alternatives><mml:math><mml:msup><mml:mi>D</mml:mi><mml:mn>3</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="xu-ieq2-2987837.gif"/></alternatives></inline-formula>, which minimizes the cross-rack repair traffic against a single node failure. Thanks to the uniformity of <inline-formula><tex-math notation="LaTeX">$D^3$</tex-math><alternatives><mml:math><mml:msup><mml:mi>D</mml:mi><mml:mn>3</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="xu-ieq3-2987837.gif"/></alternatives></inline-formula>, the proposed recovery approach balances the repair traffic not only among nodes within a rack but also among racks. We implement <inline-formula><tex-math notation="LaTeX">$D^3$</tex-math><alternatives><mml:math><mml:msup><mml:mi>D</mml:mi><mml:mn>3</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="xu-ieq4-2987837.gif"/></alternatives></inline-formula> over Reed-Solomon codes and Locally Repairable Codes in Hadoop Distributed File System (HDFS) with a cluster of 28 machines. Compared with RDD, our experiments show that <inline-formula><tex-math notation="LaTeX">$D^3$</tex-math><alternatives><mml:math><mml:msup><mml:mi>D</mml:mi><mml:mn>3</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="xu-ieq5-2987837.gif"/></alternatives></inline-formula> significantly speeds up the failure recovery up to 2.49 times for RS codes and 1.38 times for LRCs. Moreover, <inline-formula><tex-math notation="LaTeX">$D^3$</tex-math><alternatives><mml:math><mml:msup><mml:mi>D</mml:mi><mml:mn>3</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="xu-ieq6-2987837.gif"/></alternatives></inline-formula> supports front-end applications better than RDD in both of normal and recovery states.
Entanglement-enhanced estimation of a parameter embedded in multiple phases

Quantum enhanced sensing promises to improve the performance of sensing tasks using non-classical probes and measurements using far less scene-modulated photons than possible by the best classical scheme, thereby gaining previously-inaccessible information about a wide range of physical systems. We propose a generalized distributed sensing framework that uses an entangled quantum probe to estimate a scene-parameter that is encoded within an array of phases, with a functional dependence on that parameter determined by the physics of the actual system. The receiver uses a laser light source enhanced by quantum-entangled multi-partite squeezed-vacuum light to probe the phases, to estimate the desired scene parameter. The entanglement suppresses the collective quantum vacuum noise across the phase array. We show our approach enables Heisenberg limited sensitivity in estimating the scene parameter with respect to total probe energy, as well as with respect to the number of modulated phases, and saturates the quantum Cramer Rao bound. We apply our approach to examples as diverse as radio-frequency phased-array directional radar, beam-displacement tracking for atomic-force microscopy, and fiber-based temperature gradiometry.
MM Algorithms for Joint Independent Subspace Analysis with Application to Blind Single and Multi-Source Extraction

In this work, we propose efficient algorithms for joint independent subspace analysis (JISA), an extension of independent component analysis that deals with parallel mixtures, where not all the components are independent. We derive an algorithmic framework for JISA based on the majorization-minimization (MM) optimization technique (JISA-MM). We use a well-known inequality for super-Gaussian sources to derive a surrogate function of the negative log-likelihood of the observed data. The minimization of this surrogate function leads to a variant of the hybrid exact-approximate diagonalization problem, but where multiple demixing vectors are grouped together. In the spirit of auxiliary function based independent vector analysis (AuxIVA), we propose several updates that can be applied alternately to one, or jointly to two, groups of demixing vectors. Recently, blind extraction of one or more sources has gained interest as a reasonable way of exploiting larger microphone arrays to achieve better separation. In particular, several MM algorithms have been proposed for overdetermined IVA (OverIVA). By applying JISA-MM, we are not only able to rederive these in a general manner, but also find several new algorithms. We run extensive numerical experiments to evaluate their performance, and compare it to that of full separation with AuxIVA. We find that algorithms using pairwise updates of two sources, or of one source and the background have the fastest convergence, and are able to separate target sources quickly and precisely from the background. In addition, we characterize the performance of all algorithms under a large number of noise, reverberation, and background mismatch conditions.
Acetylene Detonations near the Upper Limit of Detonability

In the past detonations in the acetylene oxygen system have often been investigated in tubes, which were relatively short compared to their diameter. This paper describes experiments with detonations and combustion processes for acetylene concentration from 50 to 100% in tubes of 10, 16 and 24mm diameter and tube length corresponding to 1000 tube diameters or more. Initial conditions were room temperature and normal pressure. The detonations were photographed with a drum camera over a tube length of 2m. In addition pressure pro les were registered at di erent positions. For the initiation of the detonations fully developed \good" detonations of mixtures of C2H2=O2 were used. The measured detonation velocities [1] were in good agreement with those reported by Dixon, Breton [2], Le Chatelier, Kistiakowsky [3, 4] a. o. Up to the limit of soot formation ( 55% C2H2) they were also in good agreement with calculated (ZND model) values. For richer mixtures, towards the upper limits of detonability the velocity uctuations of the detonations increased. This can be attributed to a large extent to the formation of soot and it is as well observed in detonations of other fuel-oxidizer systems which form soot [5, 6, 7]. The limits of detonability (see Fig. 1) reported by Breton [2] and by Kistiakowsky [3] are at 92, resp. 90% C2H2. They have been measured in relatively short tubes. In our experiments we found similar values in the 10 and 16mm tubes for a tube length of 4m. For longer tubes (> 9:5m) the limit of detonability came close to 95%. Towards the limit velocity uctuations become, however, rather large as shown in Fig. 1. The line 2 in Fig. 1 are computed values from Kistiakowsky for gaseous reaction products, line 3 includes heterogeneous (graphite) products. Line 5 is computed for soot with a hydrogen content of 7mole% as found in our experiments. As photographs show, the deviation between measured and computed detonation velocities are related to the extension of the soot formation zone.
Bioaccumulation monitoring of chemical contaminants in musselsMytilus galloprovincialis from the southern coast of the Marmara Sea, Turkey

Mytilus galloprovincialis, the Mediterranean mussel, is an important shellfish species that constitutes the majority of production and consumption among bivalve mollusks in Turkey. Since shellfish can accumulate toxic chemicals from seawater, it is important to monitor bioaccumulation from their natural beds. For this reason, in this study, the aim was to monitor the levels of dioxins and dioxin-like polychlorinated biphenyls PCBs , polycyclic aromatic hydrocarbons PAHs , and toxic metals Pb, Cd, and Hg in M. galloprovincialis collected from the southern coast of the Marmara Sea from 2014 to 2017. According to the results, the maximum levels of dioxins, PAHs, and toxic metals during the monitoring period were determined as 0.30 pg/g, 2.52 mg/kg, and 0.43–0.34–0.76 Pb–Cd–Hg mg/kg, respectively. Dioxin, PAHs, and toxic metal amounts in mussel samples were determined to be below the threshold levels enforced by the European Commission. The highest benzo a pyrene and total PAHs were determined in winter 2015, while toxic metals, dioxins, and dioxin-like PCBs WHO/PCDD/F-PCB-TEQ were higher in autumn 2014 than the rest of the sampling period. In conclusion, toxic chemicals monitored in M. galloprovincialis were found at low concentrations from the point of view of food safety. However, monitoring of these or other toxic chemicals should be repetitively performed in the future to ensure food safety in aquatic animals
The Journal of Rheumatology interphalangeal joints in psoriatic arthritis: a retrospective cohort study Psoriatic nail dystrophy is associated with erosive disease in the distal

Objective : To assess if the association between psoriatic nail dystrophy and radiographic damage in the hands of patients with psoriatic arthritis (PsA) is specific to the distal interphalangeal joints. Methods : A convenience sample of patients were collated from the Bath longitudinal PsA cohort. All patients had PsA according to the CASPAR criteria, scored radiographs of their hands, and documented nail scores as measured by the Psoriatic Nail Severity Score (PNSS). Chi-square tests were performed to examine for association between features of nail dystrophy and radiographic damage in the distal interphalangeal joints (DIPjs), and proximal interphalangeal or metacarpophalangeal joints (non-DIPjs) of the corresponding digits. Results : 134 patients were included, with a median age of 53 (IQR 44, 61) years and disease duration of 7 (IQR 3, 15) years. The presence of any form of psoriatic nail dystrophy was associated with erosion at the DIPjs of the corresponding digit (OR 1.9; 95% CI 1.23, 2.83; p<0.004) and this association was primarily driven by the presence of nail onycholysis (OR 1.72; 95% CI 1.12,
IDENTIFYING DIGITAL BIOMARKERS OF DEMENTIA-RELATED AGITATION: PRELIMINARY RESULTS FROM THE MODERATE STUDY

Abstract Agitation is a challenging dementia-related behavioral symptom and disconcertingly leads to an undesirable increase in pharmaceutical intervention. Agitation is primarily assessed subjectively by time-impoverished caregivers or clinicians, who may not be able to provide comprehensive or sensitive enough reporting to detect early signs of agitation or identify its precipitants. The purpose of the MODERATE (Monitoring Dementia Related Agitation Using Technology Evaluation) study is to characterize dementia-related agitation and its potential catalysts using wearables and sensors installed in participants’ private living quarters within memory care (skilled nursing) facilities. Preliminary data from seven episodes of agitation–reported by nursing staff and treated by pharmaceutical intervention–were captured and characterized with an integrated network consisting of research-grade actigraphy, passive infrared presence sensors, door contact sensors, ambient environmental sensor boards, and bed sensor mats. Behaviors (e.g. pacing, space transitions) during 8-hour nursing shifts that included episodes of agitation were compared with 8-hour nursing shifts without any episodes of agitation. The environmental conditions (temperature, lighting, humidity, and decibel level) during agitated periods and non-agitated periods were also compared. There was a statistically significant difference between agitated periods and non-agitated periods for the number of space transitions in the living room (p<0.01) and for the measured amount of ambient light and humidity (p <0.05). Passive monitoring of behavioral activity is a promising method of unobtrusive, early, and objective detection of dementia-related agitation, expanding the window of opportunity for identifying factors associated with behavioral change and delivering appropriate evidence-based interventions.
Guidelines for Useful Integration of Patient-rated Outcome Measures into Clinical Practice

Patient-rated outcome (PRO) measures provide valuable information for communication between clinicians and patients. Adopting PROs into clinical practice may be challenging. Four generic PRO measures that are applicable to athletic training practice are described, with psychometric data detailed. Clinicians may use the information and guidelines to integrate these PROs into practice.
THE VALUE OF IRON SALTS IN COUNTERACTING THE TOXIC EFFECTS OF GOSSYPOL

The fatal results which often follow the prolonged feeding of large amounts of cottonseed meal to many animals are well known. Many attempts have been made to avoid such results and some have met with considerable success. Several years ago Withers and Brewster (1) reported successful attempts to avert this so called cottonseed meal toxicity in rabbits by administering iron salts to the animals on cottonseed meal diets. These investigators were led to employ iron as an antidote on the assumption that the toxic principle of the meal was a constituent of the protein molecule which acted upon the iron of the blood. Later researches by Withers and Carruth (2) showed the toxic substance to be gossypol. In the study first mentioned, a number of animals was given access to cottonseed meal diets which furnished 15 gm. of cottonseed meal per animal, per day. Another group of animals was given the same amount of meal, with the addition of 0.3 gm. of citrate of iron and ammonia. As a result, the average span of life for the animals not receiving iron was 13 days, but the animals receiving the iron in their diet were alive and normal after 41 days. The investigation was continued by Withers and Carruth (3), who employed copperas and ferric chloride in two different amounts to overcome cottonseed meal poisoning in young pigs. Their results show that the iron had a decidedly beneficial effect, since deaths were either postponed or averted, and the animals made better gains. The amount of soluble iron used in these feeding experiments was in the case of the rabbit feeding 0.4 gm. per 100 gm. of meal, and in the case of the pig feeding 0.4 gm. in one instance, and twice this amount in another instance, per 100 gm. of meal. Since the only source of iron, other than that purposely added, was confined to the small amount present in the meal and corn which made up the diets, the investigators were of the opinion
Insight into human brain evolution through phylogenetic analysis and comparative genomics

There is a well-established allometric relationship between brain and body mass in mammals. Deviation of relatively increased brain size from this pattern appears to coincide with enhanced cognitive abilities. To examine whether there is a phylogenetic structure to such episodes of changes in encephaliazation across mammals we used phylogenetic techniques to analyze brain mass, body mass, and encephalization
Parasitic nematode ion channels : improving understanding of pharmacology and genetic composition

Actuellement, les infections des humains, des plantes et des animaux par les nematodes parasites ont un impact economique majeur. En l’absence de vaccin efficace, les anthelminthiques sont les principaux agents chimiotherapeutiques utilises pour le traitement et la prophylaxie des infections a nematodes. Cependant, la resistance est apparue pour la plupart des anthelminthiques. Par consequent il est urgent de comprendre la genetique des recepteurs cibles par ces anthelminthiques et de trouver des cibles alternatives afin de developper de nouveaux anthelminthiques. Nous avons demontre les effets du nouvel anthelminthique cyclooctadepsipeptide, emodepside, sur le potentiel de membrane et les courants voltagedependants chez le parasite du porc Ascaris suum. Enfin, nous avons clone quatre genes codant des sous-unites du recepteur de l'acetylcholine d'un autre parasite du porc, Oesophagostomum dentatum et caracterise dans des ovocytes de Xenopus laevis quatre sous-types de recepteurs au levamisole.
Superoxide Dismutase (SOD),a Powerful Antioxidant, is now available Orally

Oxidative stress ,the natural consequence of the oxy- gen metabolism, is normally controlled by antioxidant endo- genous defense systems.Whe n these prove to be insufficient, cellular lesions develop that result in ageing but also in som e pathological processes.The powerful natural antioxidant enzyme s uperoxide dismutase (SOD) acts at the very source of the chain reaction resulting in reactive types of oxygen and therefore constitutes the first and one of the main links of the defense process against free radicals.Unf ortunately,d ue to the fragility of its molecular structure, non-protected SOD is inactivated in t he digestive tract.Thank s to a coupling pro- cess with gliadin, a protein extracted from wheat,a SOD of vegetable origin (melon extract rich in SOD) is now available orally.Several in vivo studies on animals as well as a clinical trial using healthy volonteers confirmed t he preservation of the antioxidant activity of the SOD enzyme after oral adminis- tration;an action moreover combined with anti-inflammatory and immunomodulatory properties.
Root-knot nematode

Root knot first attracted attention in 1855 when it was found in a greenhouse in England. Since then it has been a cause for concern over much of the world. It affects more than 2,000 species of plants including economically important forage crops, small grains, fruits, vegetables, field crops, nursery crops, and turf grasses. Root knot nematodes are cosmopolitan in distribution and occur widely in the United States.
Dissection of the mitotic and nuclear functions of Chromator, a nuclear-derived spindle matrix component in Drosophila

To study the mitotic function of the spindle matrix complex protein, Chromator, we used two new loss-of-function alleles in the Chromator gene, Chro 71 and Chro 612 . We show that neuroblasts from transheterozygous Chro 71 /Chro 612 brains display severely disrupted spindle morphology and chromosome segregation defects. The microtubule spindles at metaphase are rudimentary, unfocused and/or without recognizable spindle poles. At anaphase chromosomes are lagging and scattered along the microtubule fibers. To confirm that these defects were due to impaired Chromator functions, a full length Chromator trangene expressed under its own promoter was introduced into the mutant, resulting in a dramatic decrease in spindle defects to near wild type levels. The spindle defects could also be partially rescued by expression of a Chromator C-terminus trangene indicating that the Cterminal domain of Chromator might be important for its functions in spindle organization. Furthermore, we demonstrate using biochemical and immunoaffinity assays that Chromator can directly interact with microtubules as well as microtubule-based mitotic motors, Ncd. These findings strongly support the spindle matrix hypothesis and indicate that Chromator plays a functional role during mitosis.
THE EFFECTS OF BISON MEAT CONSUMPTION ON BLOOD LIPIDS AND SELECTIVE BIOMARKERS RELATED TO CARDIOVASCULAR RISK

Elevated serum lipids, blood pressure, and inflammation are related to dietary fat content and can increase the risk for cardiovascular disease. Diets lower in saturated fat have been shown to decrease cardiovascular disease risk. Dietary recommendations to consume leaner meats are often misconstrued as instructions to eliminate or greatly reduce red meat intake instead of consuming leaner red meat. The aim of this study is to investigate and compare the effects of daily consumption of two red meats, bison and beef, as part of a normal diet on cardiovascular risk factors. Twenty-four male and female volunteers (44.3±8.6 years, range 25-59 years), participated in a double-blind cross-over 16-week free living study. Prior to the trial, participants' lipid profiles ranged from normal to mildly hypercholesterolemic (201.8±34.1 mg/dL, total cholesterol range 160-260 mg/dL). Participants were randomly assigned to consume either bison or beef (6 oz for females; 8 oz for males) for 6 days per week for 42 days. Experimental trials were separated by 30 days. Then, participants consumed the other study meat. Overnight fasting blood samples were taken pre and postexperimental trials and analyzed for total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, hs-C-reactive protein, and lipoprotein particle size. Body weights and composition did not change significantly during the trial. There were no significant changes in any of the cardiovascular risk biomarkers: total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, and hs-Creactive protein. i