Miracle-dz/UniFAR-FTUs huggingface dataset:
Iloprost in COVID-19: The Rationale of Therapeutic Benefit

Recently Moezinia et al. (1) reported a beneficial effect of iloprost in the treatment of acute digital peripheral ischemia that occurred in three patients affected by acute SARS-CoV2 COVID-19 infection, and Johansson et al. (2) reported a benefit of iloprost infusion in ventilated COVID19 patients. In both these series, iloprost was infused for five continuous days at the dose of 0.5 mg/kg/min, with a clinical improvement in digital ischemia and respiratory parameters. Iloprost is a synthetic prostacyclin receptor agonist, used in the treatment of pulmonary arterial hypertension (inhalation), acute and chronic peripheral vascular disease (intravenous) such as critical ischemia, arterial obliterans diseases, digital ulcers, and severe digital ischemia in systemic sclerosis (3–5). Many reports confirm the antithrombotic, anti-inflammatory, and antifibrotic effects of iloprost and highlight its indications not only in the treatment of peripheral vascular diseases but also in critical patients without serious adverse reaction occurence (6).
Medullary Noradrenergic Neurons Mediate Hemodynamic Responses to Osmotic and Volume Challenges

Despite being involved in homeostatic control and hydro-electrolyte balance, the contribution of medullary (A1 and A2) noradrenergic neurons to the hypertonic saline infusion (HSI)-induced cardiovascular response after hypotensive hemorrhage (HH) remains to be clarified. Hence, the present study sought to determine the role of noradrenergic neurons in HSI-induced hemodynamic recovery in male Wistar rats (290–320 g) with HH. Medullary catecholaminergic neurons were lesioned by nanoinjection of antidopamine-β-hydroxylase–saporin (0.105 ng·nl−1) into A1, A2, or both (LES A1; LES A2; or LES A1+A2, respectively). Sham rats received nanoinjections of free saporin in the same regions (SHAM A1; SHAM A2; or SHAM A1+A2, respectively). After 15 days, rats were anesthetized and instrumented for cardiovascular recordings. Following 10 min of stabilization, HH was performed by withdrawing arterial blood until mean arterial pressure (MAP) reaches 60 mmHg. Subsequently, HSI was performed (NaCl 3 M; 1.8 ml·kg−1, i.v.). The HH procedure caused hypotension and bradycardia and reduced renal, aortic, and hind limb blood flows (RBF, ABF, and HBF). The HSI restored MAP, heart rate (HR), and RBF to baseline values in the SHAM, LES A1, and LES A2 groups. However, concomitant A1 and A2 lesions impaired this recovery, as demonstrated by the abolishment of MAP, RBF, and ABF responses. Although lesioning of only a group of neurons (A1 or A2) was unable to prevent HSI-induced recovery of cardiovascular parameters after hemorrhage, lesions of both A1 and A2 made this response unfeasible. These findings show that together the A1 and A2 neurons are essential to HSI-induced cardiovascular recovery in hypovolemia. By implication, simultaneous A1 and A2 dysfunctions could impair the efficacy of HSI-induced recovery during hemorrhage.
Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors

Cannabis (marijuana) has been known to humans for thousands of years but its neurophysiological effects were sparsely understood until recently. Preclinical and clinical studies in the past two decades have indisputably supported the clinical proposition that the endocannabinoid system plays an important role in the etiopathogeneses of many neuropsychiatric disorders, including mood and addictive disorders. In this review, we discuss the existing knowledge of exo- and endo-cannabinoids, and role of the endocannabinoid system in depressive and suicidal behavior. A dysfunction in this system, located in brain regions such as prefrontal cortex and limbic structures is implicated in mood regulation, impulsivity and decision-making, may increase the risk of negative mood and cognition as well as suicidality. The literature discussed here also suggests that the endocannabinoid system may be a viable target for treatments of these neuropsychiatric conditions.
Pecking Behavior in Conventional Layer Hybrids and Dual-Purpose Hens Throughout the Laying Period

To avoid the killing of surplus male layer chickens, dual-purpose hybrids are suggested as an alternative approach. These strains may offer additional advantages compared to conventional laying hens, for instance, a lower tendency to develop injurious pecking behavior. The aim of this study was to assess the behavior, with focus on pecking behavior, of conventional layers (Lohmann Brown plus, LB+) and dual-purpose hens (Lohmann Dual, LD). About 1,845 hens per strain with intact beaks were housed in four stable compartments in aviary systems. Video-based scan sampling of general behaviors and continuous observations of pecking behavior were carried out between 25 and 69 weeks of life. With the exception of “dustbathing” and “scratching,” hybrid × time during the laying period affected all of the observed general behaviors [F(2, 89) = 3.92–10.81, P < 0.001–0.05]. With increasing age, the LB+ hens performed more general pecking, more locomotion and less comfort and sitting behavior. General pecking and comfort behavior did not change over time in the LD hens, whereas inactive behaviors increased with age. During continuous observations, a significant hybrid x period interaction was found for all forms of pecking behavior [F(2, 89) = 4.55–14.80, P < 0.001–0.05]. The LB+ hens showed particularly more severe feather pecking (SFP), which increased with age. In contrast, SFP remained exceptionally low in the LD hens throughout production. Therefore, dual-purpose hybrids should be considered as an alternative to both avoid the killing of surplus male chickens and the development of SFP in laying hen production.
Corrosion Behavior of Al0.1CoCrFeNi High Entropy Alloy in Various Chloride-Containing Solutions

The present work investigates the corrosion behavior of Al0.1CoCrFeNi high entropy alloy (HEA) in various concentrations of chloride-containing solutions. Electrochemical tests exhibit overall excellent corrosion resistance of this alloy against the attack of Cl−-containing solutions. The main type of corrosion topography presents an intergranular feature. In addition, electrochemical impedance spectroscopy (EIS) investigation of the HEA samples under immersion test suggests chloride anion–containing environment leads to the decline of passivation film quality. Further analysis of XPS results reveals that significant amounts of elements exist with atomic states in the passive films.
Gradient Flotation Centrifugation of Chloroplast Membranes

1. Anti-PGL35 (Agrisera, catalog number: AS06 116) 2. Anti-TOC75 (Agrisera, catalog number: AS06 150) 3. Anti-LHCB2 (Agrisera, catalog number: AS01 003) 4. Na-ascorbate (Sigma-Aldrich, catalog number: 11140) 5. BSA fraction V (Sigma-Aldrich, catalog number: 05470) 6. PMSF/isopropanol (Sigma-Aldrich, catalog number: P7626) 7. Tricine-HCl (Sigma-Aldrich, catalog number: T0377) 8. DTT (Sigma-Aldrich, catalog number: 43819) 9. HB buffer (see Recipes) 10. TE buffer (see Recipes)
Automated Construction of Knowledge-Bases for Safety Critical Applications: Challenges and Opportunities

Creation of machine-usable, high-quality knowledge-bases is a critical prerequisite for many important applications that rely on availability of high-level of autonomous decision-making and reasoning capabilities. Manual construction of knowledge-bases for complex applications is a time-consuming and expensive process. In such application domains, however, a vast amount of knowledge is available in human-readable format, and it could be leveraged to build knowledge-bases automatically. Natural Language Processing (NLP)-based techniques provide an attractive option for this process. The field of NLP has made rapid strides in last several years and resulted in increased usage across a variety of consumer-facing applications. However, their usage for knowledge-base construction in the aviation industry remains rather limited to date. We present our assessment of using various NLP-based tools for the creation of aviation-focused, high-quality, machine-processable, and human-legible knowledge bases (KBs) for various applications. We identify several gaps, both at the application and fundamental levels, and also identify potential directions for future research that could help overcome the challenges.
Semantic Enrichment of Pretrained Embedding Output for Unsupervised IR

The rapid growth of scientific literature in the biomedical and clinical domain has significantly complicated the identification of information of interest by researchers as well as other practitioners More importantly, the rapid emergence of new topics and findings, often hinders the performance of supervised approaches, due to the lack of relevant annotated data The global COVID-19 pandemic further highlighted the need to query and navigate uncharted ground in the scientific literature in a prompt and efficient way In this paper we investigate the potential of semantically enhancing deep transformer architectures using SNOMED-CT in order to answer user queries in an unsupervised manner Our proposed system attempts to filter and re-rank documents related to a query that were initially retrieved using BERT models To achieve that, we enhance queries and documents with SNOMED-CT concepts and then impose filters on concept co-occurrence between them We evaluate this approach on OHSUMED dataset and show competitive performance and we also present our approach for adapting such an approach to full papers, such as kaggle's CORD-19 full-text dataset challenge © 2021 Copyright for this paper by its authors Use permitted under Creative Commons License Attribution 4 0 International (CC BY 4 0) CEUR Workshop Proceedings (CEUR-WS org)
XAI for Operations in the Process Industry - Applications, Theses, and Research Directions

Process industry encompasses the transformation of individual raw ingredients into final products. In-creasingly, Artificial Intelligence (AI) systems in the industry have led to higher production efficiency, reduced energy consumption, and safer operations. Despite the high degree of automation, human intervention and decision-making remain relevant and important to the required operations. In this contribution, we first present the typical requirements and challenges of applying AI to process industry followed by an overview of Explainable Artificial Intelligence (XAI). Then, we present several theses on successful adoption of XAI for process industry and consequent research gaps and directions. It is shown that the application of XAI in process industry is mainly challenging due to a wide array of requirements arising from a diverse set of AI end-users and AI application cases. An algorithm-centered perspective on XAI research is therefore not enough to address the requirements – future research needs to focus on the interplay between domain knowledge, human factors, and XAI.
That’s Fake News! Investigating How Readers Identify the Reliability of News When Provided Title, Image, Source Bias, and Full Articles

As news is increasingly spread through social media platforms, the problem of identifying misleading or false information (colloquially called “fake news”) has come into sharp focus. There are many factors which may help users judge the accuracy of news articles, ranging from the text itself to meta-data like the headline, an image, or the bias of the originating source. In this research, participants ( n = 175) of various political ideological leaning categorized news articles as real or fake based on either article text or meta-data. We used a mixed methods approach to investigate how various article elements (news title, image, source bias
Re-modeling Chara action potential: I. from Thiel model of Ca 2+ transient to action potential form

Thiel and colleagues demonstrated that the all-or-none nature of Chara action potential(AP) is determined by formation of a second messenger, probably inositol triphosphate (IP 3 ), whichin turn releases Ca 2+ from internal stores. The Ca 2+ -activated Cl – channels are the main agent of thedepolarization phase of the AP. Once the Ca 2+ is re-sequestered by the calcium pumps, the chlorideconductance drops and depolarization-activated outward rectifier current, the background current andthe proton pump current return the membrane potential difference (PD) to resting level. Departingfrom the Thiel model of transient increase of Ca 2+ concentration, we set up membrane PD rate ofchange equation to calculate the AP form by numerical integration. Compared to data, this model APdepolarized more gradually. We introduced a prompt Ca 2+ transient from the outside, achieving agood correspondence with the experimental AP. In Chara cells subjected to 50 mM NaCl/0.1 mMCa 2+ medium, the AP duration increased from 2 s to up to 50 s and the APs were often spontaneous.The lack of stimulating pulse revealed a sharp positive spike at the beginning of each AP, confirmingthat Chara plasma membrane may contain transient receptor potential (TRP)-like channels, possiblyactivated by another second messenger diacylglycerol (DAG) formed at the same time as IP 3 . Thelong duration of the saline AP can be modeled by decreasing the coefficients in the Hill equationdescribing the Ca 2+ pumps on the internal stores. The model provides new insights into the characeanAP and suggests a range of experiments.
Insight into Corporate Governance in Islamic Finance: A Systematic Review of Literature

The concept of corporate governance (CG) in Islamic banking (IB) has gained attention of researchers in the last two decades. This review paper aims to provide broad and comprehensive review of existing literature on CG in Islamic banks(IBs). The research on CG in IBs has mainly been empirical conducted mostly in Gulf Cooperation Council (GCC) and South Eastern region with a few conceptual studies. A sound theoretical base for Islamic CG studies is still missing. The results suggesting role of Shariah Supervision are elusive. The impact of emerging economies and country legal systems as antecedents of CG have not been thoroughly covered in the literature. In the field of research this topic needs to be covered more rigorously and exhaustively. CG in IBs is an emerging area of research and lack comprehensive review studies. Owing to the fact, this review paper aims to provide broad, comprehensive review of existing literature on corporate governance in IBs. which can be employed for further research about the subject matter. governance.In the next phase keywords including Islamic banks, Islamic financial institutions and corporate governance are used to retrieve articles published from year 2000 and onwards.After collecting a voluminous list of articles their abstract is read and only those studies are selected which have relevance to the subject area of research. A few working papers have also been included owing to their significance in the literature. In addition, citations within the articles are also considered to enhance the list of studies for the review.
Phytotherapeutic Interventions using Rodent Models of Hair Loss: Current Research and Future Strategy

Hair follicles are special additions to mammalian skin with intricate differentiation and growth characteristics. They constantly undergo cycles of regression and regeneration throughout the lifespan of animal. Several rodent models have been studied for androgenetic alopecia and alopecia areata in humans with only handful of products approved by United States Food and Drug Administration; topical minoxidil (men and women) and oral finasteride (only men) for hair loss indication. This review summarizes rodent models of human hair loss to emphasize their role in testing traditional medicinal plants as hair growth promoters. Review also discusses the mechanisms of action of various herbs. Currently, both natural and synthetic products are in use to remedy alopecia. Although, use of natural products has shown measurable efficacy, the option is open to test chemically synthesized active fractions of plants as monotherapy or polytherapy to facilitate approval by regulatory agencies. Overall, purpose of this review is to discuss the rodent models of efficacy and how modifications in herbal preparations may bring more alternatives and a better value to the products in future.
Growth performance and carcass characteristics of broilers fed graded levels of dry distilled cassava with soluble Oyedele, O. J., Olosunde, A. O., Otunla, T. A. and Ajibogun, F. H. A. Bioresources Development Centre Ogbomoso, National Biotechnology Agency, Abuja

This study was carried out to investigate the performance of broilers fed graded levels of Dry Distilled Cassava with Soluble (DDCS). In a 28-day trial, one hundred and forty-four (144), 5-week old, un-sexed Arbor acre strain broiler chicks (average weight of 1.09±0.02 kg) were randomly allocated to four dietary treatments of wheat offal (WO) and DDCS (12% WO + 0% DDCS = 0% DDCS; 8% WO + 4% DDCS = 4% DDCS; 4% WO + 8% DDCS = 8% DDCS and 0% WO + 12% DDCS = 12% DDCS) in completely randomized design. Each treatment had 2 replicates of 18 birds each. Dry matter feed intake (FI g/day), daily weight gain (g/day) and total weight gain (kg) decreases with increase in the levels of DDCS, while the feed conversion ratio (FCR) increases with increase in levels of DDCS, respectively. However, there was no significant (P>0.05) differences in the carcass evaluation measured. It was concluded that DDCS could replace wheat offal in the diets of broilers up to 8% without significant difference in growth and feed intake without detrimental effects on carcass quality of the birds.
A study of anthropometrical parameters among different playing positions of baseball players

Background: Anthropometry play an important role in deciding the particular build of the body with various measurements of the segments of the body it has also its importance in the field of various sports. The aim of the current study was to evaluate anthropometric characteristics Methods: The present study were consisted of 64 male inter-university baseball players from all India age ranging from 18 to 28 years belonging to Punjab, Delhi, AP and Chandigarh states of all India inter university. The purposively sampling technique was utilized to collect the required data of the subject after the match. Results: Results of the study indicated that there were significant differences in the various anthropometrical characteristics among various playing positions in Baseball. Conclusion: It is reveled from the results that inter-university baseball players significantly differed in the various measurements such as Upper Arm Circumference, Forearm Circumference and other measurements with respect to different paying positions.
Association of Hormonal status with Anthropometric & Biochemical Parameters in women with Polycystic Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the metabolic endocrine disorder that affects 4–12% women of reproductive age and is a major cause of anovulatory infertility. Besides reproductive and obstetric complications, the consequences of PCOS extend beyond the reproductive axis and may lead to the substantial risk for the development of metabolic syndrome with the characteristic features of insulin resistance, central obesity, impaired glucose tolerance, dyslipidemia and hypertension. Objectives: To evaluate the hormonal status and its association with the anthropometric measurements and biochemical parameters in females diagnosed with PCOS. Materials & Methods: In this case-control study, women clinically diagnosed with PCOS (N=85) and age matched healthy control female subjects (N=85) in the age group (18 – 35) years were enrolled. Body mass index (BMI), waist: hip ratio (WHR), Fasting Blood Glucose, Lipid profile and Hormonal levels were estimated in both the groups and further compared using student t-test. Hormonal levels were also correlated with the anthropometric measurements & biochemical parameters and the results were analyzed using Pearson’s correlation coefficients. Results: We found that the levels of TSH, LH, FSH, LH/FSH ratio & prolactin were significantly raised in PCOS females as compared to healthy females (P < 0.0001). TSH showed significant positive correlation with anthropometric measurements (BMI, waist-to-hip ratio), biochemical parameters (TC, TG, LDL & TC/HDL ratio) and hormonal profile (LH, FSH, LH/FSH ratio & Prolactin) of PCOS women. Discussion & Conclusion: We found that there is a derangement in hormonal & biochemical status of women suffering from PCOS that leads to an altered energy metabolism and endocrinological cascade of PCOS. Furthermore, our study showed high prevalence of hypothyroidism, dyslipidemia and increased levels of LH, FSH, PRL & a higher LH/FSH ratio in women with PCOS, which may further contribute towards the progress of metabolic disorders, irregular menstruation and infertility.
An In-depth Study on POS Tagging for Assamese Language

: An automatic POS tagger is an essential component of any Natural Language Processing (NLP) work. It is one of the important steps towards the processing of Natural Language. There are various challenges in the tagging of POS and most of the time these are language-dependent. Assamese is a morphologically rich and free word order language. Because of this, the challenges are even more. In the present paper, the basic concept of the POS tagger and its importance in the NLP is discussed. In the later part of the paper, the overall characteristics of the Assamese language are discussed in short and its various challenge that may arise towards the tagging of POS is discussed. The paper also discusses about the various POS tagging techniques that are commonly used in the tagging of POS.
Stakeholder collaboration inspired by the Nordic model – Towards sustainable work and competitiveness during an industrial startup

External stakeholder collaboration is vital for new industrial projects and establishments. The aim of this paper is to contribute to knowledge of how relations and stakeholder collaboration with trade unions can be created during industrial startups, so as to foster sustainable work and competitive advantages. A case study was carried out in the early phases of a major greenfield project aimed at establishing a new industrial domain in a Nordic context. The results show that cooperation between a new firm and trade unions has the potential to proactively address prerequisites for sustainable work in design phases of new factories, but also to strengthen the attention to other dimensions of social sustainability that are crucial for industrial startup´s long term success possibilities. However, specifically in a high—growth firm, there needs to be a systematic approach that incorporates continuous anchoring activities both within and between the stakeholders’ different levels. Serendipity in the findings were cooperation processes related to competence acquisition and societal development needed to meet both an emerging firm´s and future employee´s individual prerequisites and needs. Hence, building a stakeholder chain inspired by the Nordic model in change processes such as startups, enables attention to dimensions of social sustainability needed in work processes in early development phases, which is also beneficial from a competitive and societal perspective.