FİBROMİYALJİ TANISINDA İNFLAMATUAR BİR BELİRTEÇ: PLATELET DAĞILIM GENİŞLİĞİ Platelet Distribution Width As A Novel Inflammatory Marker For Fibromyalgia

OZET Amac: Fibromiyalji sendromu (FMS), coklu hassas noktalarda kronik yaygin agri ile karakterize, yorgunluk, uykusuzluk, kognitif disfonksiyonlarda bozukluk vb. sistemik semptomlarla bir arada seyreden bir sendromdur. Bu calismanin amaci, FMS tanili hastalar ile kontrol grubu arasindaki platelet dagilim genisligi (PDW), kirmizi kure dagilim genisligi (RDW), ortalama trombosit hacmi (MPV), notrofil/lenfosit orani (NLR), platelet/ lenfosit orani (PLR) hematolojik parametrelerini arastirmak ve hastalik etyopatogenezine katki saglamaktir. Gerec ve Yontem: Fizik Tedavi ve Rehabilitasyon poliklinigine ayaktan basvuran ve ‘American College of Rheumatology’ (ACR) kriterlerine gore FMS tanisi konan 200 hasta ve 65 saglikli birey calismaya dahil edildi. Muayeneleri kapsaminda ayrintili anamnez alimi, detayli fizik muayene, hematolojik ve biyokimyasal parametreleri incelendi. Istatistiksel olarak karsilastirma ve analizleri yapildi. Bulgular: FMS grubunda PDW 17,1±1,9, RDW 12,5±1,4; MPV 8,3±1,2 fentolitre (fl); NLR 1,81±0,67; PLR 114,1±32,4 idi. Kontrol grubunun ise PDW degeri 17,6±2,1 (p=0,034); RDW 12,3±1,2; MPV 8,5±1,4; NLR 1,84±1,11; PLR 111,9±38,6 idi. Yapilan karsilastirmalarda RDW, MPV, NLR, PLR de her iki grup arasinda fark saptanmazken; FMS tanili hastalarda PDW, kontrol grubuna gore istatistiksel olarak anlamli duzeyde dusuk saptandi (p<0.05). Sonuc: PDW’nin, FMS patogenezinde muhtemel inflamatuar aktivitenin hematolojik parametrelerdeki gostergesi olarak ve FMS nin erken tanisinda bir belirtec olarak rolu olabilir. Anahtar Kelimeler: Fibromiyalji sendromu; Hematolojik parametreler; Platelet dagilim genisligi. ABSTRACT Objective: Fibromyalgia syndrome (FMS) is a benign condition that is characterized by is chronic widespread pain at multiple tender points, systemic symptoms such as fatigue, cognitive dysfunction and insomnia. The aim of this study was to investigate the relationship between FMS and platelet distribution width (PDW), red cell distribution width (RDW), mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), platelets to lymphocyte ratio (PLR) and other haematological parameters. Material and Methods: The patient group consisted of 200 FMS patients who had met the American College of Rheumatology (ACR) classification criteria for FMS, and the control group consisted of 65 healthy volunteers. Carefully obtained history, detailed physical examination, hematologic and biochemical tests were performed. The groups were investigated by comparison and correlation analyzes. Results: In the FMS group PDW was 17,1±1,9; RDW was 12,5±1,4; MPV was 8,3±1,2 fl; NLR was 1,81±0,67 and PLR was 114,1±32,4. For the control group, the results were as; PDW 17,6±2,1; RDW 12,3±1,2; MPV 8,5±1,4; NLR 1,84±1,11 and PLR 111,9±38,6. There was no difference between the two groups for RDW, MPV, NLR and PLR. PDW was statistically significantly lower in FMS group than controls (p <0.05). Conclusions: PDW may play a role as an early inflammatory marker for the pathogenesis and diagnosis of FMS. Keywords: Fibromyalgia syndrome; Haematological parameters; Platelet distribution width.