Miracle-dz/UniFAR-FTUs huggingface dataset:
Next‐generation sequencing of tissue and circulating tumor DNA: Resistance mechanisms to EGFR targeted therapy in a cohort of patients with advanced non‐small cell lung cancer

Epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) has been considered as an effective treatment in epidermal growth factor receptor‐mutant (EGFR‐mutant) advanced non‐small cell lung cancer (NSCLC). However, most patients develop acquired resistance eventually. Here, we compared and analyzed the genetic alterations between tissue assay and circulating tumor DNA (ctDNA) and further explored the resistance mechanisms after EGFR‐TKI treatment.
Strategi Marketing Lembaga Pendidikan Islam “The Outstanding School Of Muhammadiyah Jawa Timur” Di SMP Muhammadiyah 12 Sendangagung Paciran-Lamongan

The Marketing Strategy Islamic Education Institution is important as a school for The Outstanding School of Muhammadiyah East Java. Research at SMP M 12 Sendangagung. Problem formulation: (1) How is the Marketing Strategy of SMP M 12 Sendangagung? (2) What are the Supporting Factors of Marketing Strategy at SMP M 12 Sendangagung? (3) What Are the Inhibiting Factors of Marketing Strategy at SMP M 12 Sendangagung? Descriptive approach qualitative method. Data collection techniques: observation, interviews, and documentation. The research results of SMP (Middle School) Muhammadiyah 12 Lamongan are marketing strategies by improving quality, applying mix marketing strategies 7P (Product, Price, Promotion, Place, People, Process, and Physical Evidence. Supporting factors of marketing strategy: (a) SMP M 12 Sendangagung in the area of Islamic boarding schools Al Islah, (b) The daily language of Arabic and English students, (c) Strategic area, (d) Promotion through internet media or websites; (e) Strategic places. Inhibiting factors: (a) of human resources for promotion; ( b) Traffic, (c) Expansion, (d) Competitive school locations are many, (e) Administrative staff are only administration staff.
Algoritmo de Encriptación para Imágenes a color basado en Sistemas Caóticos

% Abstract Context: Taking advantage of the foundations of the theory of non-linear dynamic systems, we propose an encryption model for color images based on chaotic systems, which satisfies security standards in accordance with the challenges faced by society. Method: A symmetrical algorithm is proposed using Arnold’s chaotic Cat system for permutation and for diffusion Chen’s hyperchaotic system or Lorenz’s hyperchaotic system, a parallel programming in implementation is used to reduce execution times. Results: Performance metrics are applied to evaluate the security of the proposed cryptographic model, finding that the indicators obtained are framed within those published in recent articles that address the problem of security through chaos. Conclusions: The results obtained confirm that the use of chaos theory as a tool for strengthening security schemes in communications is a good alternative, particularly when referring to image transfer.
Comprehensive Analysis of NAC Transcription Factor Family in Pearl Millet Uncovers Drought and Salinity Stress Responsive NAC in Pearl Millet (Pennisetum Glaucum)

Background: Pearl millet (Pennisetum glaucum) is a cereal crop that possesses the ability to withstand drought, salinity and high temperature stresses. The NAC [NAM (No Apical Meristem), ATAF1 and (Arabidopsis thaliana Activation Factor 1), and CUC2 (Cup-shaped Cotyledon)] transcription factor family is one of the largest transcription factor families in plants. NAC family members are known to regulate plant growth and abiotic stress tolerance. Currently, no reports are available on the functions of the NAC family in pearl millet. Results: Our genome-wide analysis found 151 NAC transcription factor genes (PgNACs) in the pearl millet genome. Phylogenetic analysis divided these NAC transcription factors into 11 groups (A-K). Three PgNACs (-073, -29, and -151) were found to be membrane-associated transcription factors (MTF). Seventeen other conserved motifs were found in PgNACs. Based on the similarity of PgNACs to NAC proteins in other species, the functions of PgNACs were predicted. In total, 88 microRNA target sites were predicted in 59 PgNACs. A previously performed transcriptome analysis suggests that the expression of 30 and 42 PgNACs are affected by salinity stress and drought stress, respectively. The expression of 36 randomly selected PgNACs was examined by quantitative reverse transcription-PCR. Many of these genes showed diverse salt- and drought-responsive expression patterns in roots and leaves. These results confirm that PgNACs are potentially involved in regulating abiotic stress tolerance in pearl millet.Conclusion: The pearl millet genome contains 151 NAC transcription factor genes that can be classified into 11 groups. Many of these genes are either upregulated or downregulated by either salinity or drought stress and may therefore contribute to establishing stress tolerance in pearl millet.
EFECTO DE LA FUENTE LIPÍDICA EN LA ALIMENTACIÓN DE POLLOS PARA CARNE EN ZONA DE TRÓPICO

The objective of the study was to evaluate the use of different sources of lipids (soybean oil, lard and recycled oil) in the diet of meat chickens, carried out in the Tro? pico - Quillabamba - Cusco - Peru at 700 m. of altitude; 120 bb Cobb-500 males, 1 day old, with a duration of 42 days, were used. In the initial stage, the use of lard and recycled oil determined a better productive response, both for weight, weight gain and feed conversion, with no effect on feed consumption being observed. In the growth stage and complete cycle, all the evaluated sources determined a reduction in feed intake and an improvement in feed conversion and, in the case of soybean oil and whole soybean meal, a higher breast yield (%); weight gain and carcass performance were not affected by the use of lipids in the diet, having obtained similar results to those achieved with the control group; abdominal fat (weight and percentage) was higher with recycled oil and lard. It is concluded that the use of soybean oil, recycled oil and lard determines similar productive responses, with greater effect in the deposition of abdominal fat.
Crowdsourcing Framework for QoE-Aware SD-WAN

The exponential increase in bandwidth-sensitive multimedia traffic on the Internet has created new challenges and opportunities. With the shifting focus from service availability to service quality, there is a need to have quality management measures to serve the high needs of efficient transmission and delivery in time-constrained environments over IP networks. Quality of Experience (QoE) is now considered the most important measure to achieve the twin goals of application efficiency and user satisfaction from a user perspective. In this paper, we propose a framework that can be used to collect real-time QoE feedback through crowdsourcing and forward it to SD-WAN controllers to enhance streaming routes based on real-time user quality perceptions. We analyze how QoE can be affected by different network conditions, and how different streaming protocols compare against each other when the network parameters change dynamically. We compare the real-time user feedback to predefined network changes to measure if participants will be able to identify all degradation events, and to examine which combination of degradation events are noticeable to the participants. These QoE timestamped feedback is sent back to the SD-WAN controller continuously in order to locate problems and bottlenecks in the current service paths and to enable network controllers to take corrective action by rerouting the streamed traffic. Our aim is to demonstrate that real-time QoE feedback can enhance cloud-based services and can adjust services quality based on real-time, active participants’ interaction[1]. [1] This paper extends the preliminary results presented by the authors at the PVE-SDN 2019 workshop in IEEE Conference on Network Softwarization (NetSoft 2019).
No More Excuses! Performance of ESG-Integrated Portfolios in Australia

We find compelling evidence that integrating Environment, Social and Governance (ESG) analyses into ongoing investment practices in Australia does not harm risk-adjusted returns. High-ESG-rated portfolios consistently provide superior outperformance, diversification efficiencies, and lower overall risk compared to low-ESG-rated portfolios. In contrast to low-rated portfolios, we find no evidence that high-ESG rated portfolios underperform the market. All results remain robust to alternate time periods, market cycles, seasonality effects, ratings method and the inclusion of trading costs and management fees. Overall, our findings suggest that a simple ESG-integration strategy may provide a natural hedge against the risks that arise from the evolving fiduciary responsibilities of professional investment managers relating to ESG risks.
Chemical engineering of mixed halide hexaborates as nonlinear optical materials

Mixed nonlinear optical (NLO) crystals have been widely investigated to precisely optimize their optical properties by controlling the compositions, and have drawn immense attention in the laser science and technology field. Herein, a series of mixed NLO crystals K3B6O10Br1−xClx (x = 0, 0.21, 0.35, 0.47, 0.57, 0.75 and 1) were obtained using spontaneous nucleation and a bulk crystal of K3B6O10Br0.53Cl0.47 with the size 41 × 26 × 15 mm3 was successfully grown by a top seeded solution growth (TSSG) method. The NLO properties of the mixed crystals were studied by combination of second harmonic generation (SHG) tests and first-principles calculations. As a potential mixed crystal for practical application, the optical properties of the K3B6O10Br0.53Cl0.47 crystal including transparency range, refractive indices, the shortest SHG phase-matching wavelength and angle were investigated. The results indicate that the optical performance of the mixed crystals can be effectively adjusted to optimize practical high power laser output by tuning substitution compositions.
The effect of municipal sewage sludge on growth of transplants and fruit quality of eggplant (Solanum melongena) and tomato (Lycopersicon esculentum)

Eggplant and tomato transplants were grown for a two years period (1998-99) in commercial peat or in culture media containing different percentages (25, 50, 75 and 100%) of municipal sewage sludge compost (MSSC) mixed with river sand. The mean height of eggplant transplants was significantly enhanced by the 50% MSSC medium, while the tomatoes one by the medium containing 75% of MSSC. Main stem diameter of both species was greatest for those grown in peat, followed for eggplant by a medium containing 50% of MSSC and for tomato by a medium containing 75% of MSSC. Above ground fresh and dry biomass weight of eggplant transplants were the highest when grown in medium containing 50% of MSSC, while for tomato transplants the highest biomass production was for a medium containing 75% of MSSC. Concentration of heavy metals in transplants and fruits of both species was low for all percentages of MSSC used. These findings indicated that the material tested was not an environment polluting factor and was suitable for healthy vegetables production. Therefore it is assumed that MSSC can be used as an alternative low cost organic component in growing media and decrease the Greek dependency on imported materials necessary for vegetable transplants growth.
Changes in composition of phenolic compounds and tocopherols in broccoli heads during short-term storage

Broccoli (Brassica oleracea L. var. italica) contains numerous biologically active compounds. However, their levels change during processing and storage. The objective of the research study was to determine the effect of short-term storage (1 ÷ 4 days) of broccoli heads at different temperatures (3 oC, 16 oC, and 21 oC) on the contents of phenolic acids, selected flavonoids (quercetin and kaempferol), and tocopherols. Broccoli heads were harvested in autumn when they reached their maximum size and their buds were 2 mm in diameter. The content of phenolics and tocopherols depended on the storage time of broccoli heads. The lowest content of phenolics was found immediately after the broccoli was harvested, whereas the highest content thereof was reported after 4 days of storage. However, the storage temperature did not impact the contents of those compounds. In the research study, the content of caffeic acid was reported to be highest in the fresh broccoli heads; the content of sinapic acid was the second-highest, and that of the ferulic acid was the third-highest. The content of kaempferol in the broccoli heads was higher than that of quercetin. No differences were reported in the content of quercetin and kaempferol at particular storage temperatures on every single day of the experiment. An increase was reported only when compared with the control sample (the 0 day of storage). In the broccoli heads, the predominant tocopherol was α-tocopherol. The lowest loss in the total tocopherols occurred while storing at a temperature of 3 oC and the highest: at a temperature of 21 oC.
A Versatile Tiling Light Sheet Microscope for Cleared Tissues Imaging

We present a tiling light sheet microscope compatible with all tissue clearing methods for rapid multicolor 3D imaging of centimeter-scale cleared tissues with micron-scale (4×4×10 µm3) to nanometer-scale (70×70×200 nm3 spatial resolution. The microscope uses tiling light sheets to achieve a more advanced multicolor 3D imaging ability than conventional light sheet microscopes. The illumination light is phase modulated to adjust the 3D imaging ability of the microscope based on the tissue size and the desired spatial resolution and imaging speed, and also to keep the microscope aligned. The ability of the microscope to align via phase modulation alone also makes the microscope reliable and easy to operate. Here we describe the working principle and design of the microscope. We demonstrate its imaging ability by imaging various cleared tissues prepared by different tissue clearing and tissue expansion techniques.
E-Government Readiness: Penilaian Kesiapan Aktor Utama Penerapan E-Government di Indonesia (E-Government Readiness: Main Actor Readiness Assessment for E-Government Application in Indonesia)

E-Government telah terbukti dapat meningkatkan akuntabilitas, transparansi dan keadilan dalam penyediaan layanan publik. Sistem ini juga menciptakan birokrasi yang efektif dan efisien serta mendorong partisipasi pemangku kepentingan dalam perumusan kebijakan publik. Indonesia telah menerapkan e-government selama hampir dua dekade, sejak diberlakukannya Instruksi Presiden No. 3 Tahun 2003 tentang Kebijakan dan Strategi Nasional. Akan tetapi, penerapan e-Government belum menunjukkan hasil yang optimal karena belum dilakukan secara merata dan levelnya berada di bawah rata-rata regional Asia Tenggara. Kegagalan penerapan e-government disebabkan oleh ketidakpahaman pemerintah tentang e-readiness dan pengambilan keputusan tanpa mempertimbangkan bukti yang memadai. Penelitian ini menilai tingkat kesiapan Kementerian Kominfo sebagai aktor utama penerapan e-government dengan mengadopsi dan memodifikasi framework STOPE. Hasilnya menunjukkan bahwa Kementerian Kominfo berada dalam kondisi cukup siap. Akan tetapi, terdapat beberapa permasalahan yang perlu diatasi, seperti keterbatasan anggaran, SDM, regulasi, teknologi dan infrastruktur serta kurangnya lingkungan yang mendukung.
Effect of Adding Smoke Liquid or Powder to Goat’s Milk on Some Characteristics of Domiatti Cheese

The impact of adding smoke liquid and powder to goat's milk on the quality of Domiatti cheese was studied. Seven treatments were done by adding of 0.4, 0.5 and 0.6% smoke liquid or 0.75, 1.00 and 1.25% smoke powder to goat's milk. The obtained results showed that addition of smoke materials decreased the rennet coagulation time and curd tension while increased syneresis values of goat's milk. Smoked Domiatti cheese had the highest values for titratable acidity Total solids (TS), fat, salt, salt in moisture and TN contents of control and smoked Domiatti cheese samples did not differ clearly. Adding of smoke liquid and powder to cheese milk slightly decreased WSN, NPN and TVFA values of cheese. The total phenolic contents in the smoked cheese were higher than the control. Admixing smoke liquid or powder to goat’s milk reduced the content of saturated fatty acids and increased unsaturated fatty acids of cheese samples. The amounts of short and medium chain fatty acids were lower while long chain fatty acids were higher in smoked cheese as compared with control. The essential fatty acid, linoleic acid (C18:2) was higher in smoked cheese. Mixing of smoke liquid or powder to goat’s milk significantly reduced total viable bacterial counts and the viable counts of proteolytic, lipolytic bacteria, moulds and yeasts of cheese. Smoking cheese by adding 0.4 and 0.5% smoke liquid (50%) or 0.75% smoke powder gives the most desirable smoked flavor in Domiatti cheese.
Olive oil enrichment in phenolic compounds during malaxation in the presence of olive leaves or olive mill wastewater extracts

A combined study was performed to determine the effect of olive leaf aqueous extract (OLE), olive mill wastewater (OMWW) or water addition during the malaxation step on total phenolic content (TPC), antioxidant activity, virgin olive oil composition and quality parameters of olive oil. For these purposes, the Folin-Ciocalteu assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and HPLC-ESI-TOF/MS were employed. The experiments were carried out at semi-industrial scale in a cold extraction olive oil mill using olives of Koroneiki cultivar. Olive oil produced by olive paste which was malaxed without adding water, OMWW, or OLE was employed as control. The use of OMWW and OLE allowed obtaining oils with higher significant TPC compared to that malaxed with water (146.2 and 151.8 vs. 132.8 μg Eq GAE/g oil, respectively). The antioxidant activity followed the same trend. The use of OMWW and OLE enabled an oil enrichment in oleuropein derivatives, especially in 3,4-DHPEA-EDA. Despite the fact that acidity and oxidation (K270 and K232 values) were higher in the aforementioned oils compared to the oil extracted with water, all values were under the European Union commission parameters for extra virgin olive oil (EVOO) denomination. However, only the oil extracted using OLE presented slightly higher fruity, bitter, and pungent positive attributes compared to the control and to the oil extracted with water, thus, making OLE a promising by-product for improving olive oils. Practical applications: This research provides new insight for the improvement of olive oil extraction process in order to obtain high-phenol EVOO which could be useful for the olive oil, nutraceuticals, and cosmeceuticals industries. Besides, this study could serve as a starting point for improving the olive oil production process, while reducing the impact of its by-products. The addition of Olive mil wastewater (OMWW) and olive leaf extract during malaxation, allowed obtaining enriched oils with a higher content in total phenolics, and antioxidant activity compared to those obtained adding water. These enriched oils presentes higher quantities of oleuropein derivatives and specifically of 3,4-DHPEA-EDA.
Multicomponent stereo and regioselective reactions of beta lactams in water: Click reaction

Multicomponent reaction in water was used to prepare a series of triazole substituted trans-beta-lactams from the corresponding trans-4-acetoxylactam, sodium azide, and alkynes via a Cu(I)-catalyzed click chemistry with base free. This highly stereo and regioselective procedure is simple, clean and efficient.
Research Progress of Miniature Near Infrared Spectrometer

: The development of a miniature near infrared spectrometer at a global level is herein summarized. The development prospect of the aforementioned spectrometer is then predicted. This spectrometer is expected to have high signal-to-noise ratio, high resolution, and high stability, as well as involve the use of new materials and technology, while ensuring its specialization in specific fields.
New insights in Diffuse Large B Cell Lymphoma Pathobiology

Diffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), accounting for about 40% of all cases NHL. Analysis of the tumour microenvironment is an important aspect of the assessment of the progression of DLBCL. In this review article, we have analyzed the role of different cellular components of the tumour microenvironment, including mast cells, macrophages, lymphocytes, in tumour progression of DLBCL. We examined several approaches to confront the available pieces of evidence; three key points emerged. DLBCL is a disease of malignant B-cells spreading and accumulating both at nodal and in extranodal sites. Both in patients with nodal and extranodal lesions, the subsequent induction of a cancer-friendly environment appears pivotal. DLBCL cell interaction with mature stromal cells and vessels confers tumour protection and inhibition of immune response while delivering nutrients and oxygen supply. Single cells may also reside and survive in protected niches in the nodal and extranodal sites as a source for residual disease and relapse. This review aims to molecularly and functionally recapitulate the DLBCL-milieu crosstalk, to relate niche and pathological angiogenic constitution and interaction factors to DLBCL progression.
Nucleation and Growth of Hexagonal Ice by Dynamical Density Functional Theory

We propose a dynamic density functional theory to describe the transition process from disordered liquid water to ordered ice crystal. With the special consideration of the enhanced and ordered hydrogen bonding in the crystal and the hydrodynamic interactions induced by the flow of water molecules, the theory is able to reproduce the process of nucleation and growth of ice crystal. Some theoretical predictions are in general agreement with the available computational and experimental data, indicating that the theory provides a reasonable description of the dynamic process of ice crystal growth.