Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimising antidepressant use in clinical practice: towards criteria for antidepressant selection

Background Current treatment for depression in primary care and other out-patient settings demonstrates a pattern that is incongruous with the magnitude of the burden of depression suggested by its associated disability. Aims To review important considerations in current depression treatment with a focus on antidepressant use. Method Factors influencing the under treatment of depression in real-world settings are examined. Results Patient and clinician behaviour as well as the incentives created by the health care system affect the likelihood of realising effective antidepressant therapy in practice. Conclusions Given the complexities of clinical practice, selection criteria for an antidepressant should include safety, efficacy and tolerability, as well as the ability of the antidepressant to deliver real-world efficacy while balancing health care costs in the long term.
REDUCTION OF POSTOPERATIVE PAIN BY ENCOURAGEMENT AND INSTRUCTION OF PATIENTS. A STUDY OF DOCTOR-PATIENT RAPPORT.

MANY reports have discussed the treatment of patients suffering after operation. Narcotics are not without danger; they also vary considerably in effectiveness. Hypnosis will reduce pain but is difficult to achieve and requires special training for the operator. Despite considerable effort the problems of treating postoperative pain remain. Janis1 has shown that patients who were told about their operations before the procedure remembered the operation and its sequelae more favorably than those who were not well informed. We have determined the effects of instruction, suggestion and encouragement upon the severity of postoperative pain. Method We studied 97 patients after elective .
The Influence of Audit Committee and Internal Auditor Toward the Prevention of Fraud (a Survey in Soes of Indonesia)

The weakness of corporate governance is often called as the cause of some frauds and accounting scandals that were uncovered recently. It requires information quality, and freefromdistortion. Some cases both nationally and internationally indicate the occurrence of irregularitiesin financial reportingdue tothe weakness of the company's internalcontrol system, and theaudit committee has notfunctioned optimally. The audit committee has the responsibility to supervise matters that potentially contain risks in the internal controlling system and to monitor the supervision process conducted by internal auditor, to conduct examination and assessment on sufficiency and effectiveness of internal controlling system. The results show that audit committee optimalization must having experience as auditor in public accountant office and the internal auditor must be improved through quality of internal auditor responsibility in prevention of fraud.
The tumor necrosis factor ligand and receptor families.

Tumor necrosis factor (TNF) and lymphotoxin-α were isolated more than 10 years ago, on the basis of their ability to kill tumor cells in vitro and to cause hemorrhagic necrosis of transplantable tumors in mice.1 The complementary DNAs and genes encoding each protein were cloned immediately thereafter.2,3 Concurrently, a factor known as cachectin was isolated from mouse macrophages, sequenced, and shown to be identical to TNF.4,5 Cachectin was identified not as a cytolysin, but as a catabolic hormone that suppressed the expression of lipoprotein lipase and other anabolic enzymes in fat.6–8 Still other studies demonstrated the powerful .
Differential Diagnosis of Cushing ’ s Syndrome

The differential diagnosis of Cushing’s syndrome requires careful multidisciplinary interaction with a number of specialities, co-ordinated through endocrine centres with good experience of this condition. It is essential that the diagnosis of Cushing’s syndrome be fully established before differential diagnosis is attempted. The endocrinologist needs to be aware of the pitfalls and advantages of the tests in use. We discuss the approach to the differential diagnosis of this challenging condition. (Arq Bras Endocrinol Metab 2007;51/8:1199-1206)
Metabolism Cancer Growth through Saturated Long-Chain Fatty Acid Novel Lipogenic Enzyme ELOVL 7 Is Involved in Prostate

A number of epidemiologic studies have indicated a strong association between dietary fat intake and prostate cancer development, suggesting that lipid metabolism plays some important roles in prostate carcinogenesis and its progression. In this study, through our genome-wide gene expression analysis of clinical prostate cancer cells, we identified a novel lipogenic gene, ELOVL7 , coding a possible long-chain fatty acid elongase, as overexpressed in prostate cancer cells. ELOVL7 expression is regulated by the androgen pathway through SREBP1, as well as other lipogenic enzymes. Knockdown of ELOVL7 resulted in drastic attenuation of prostate cancer cell growth, and it is notable that high-fat diet promoted the growth of in vivo tumors of ELOVL7-expressed prostate cancer. In vitro fatty acid elongation assay and fatty acid composition analysis indicated that ELOVL7 was preferentially involved in fatty acid elongation of saturated verylong-chain fatty acids (SVLFA, C20:0f). Lipid profiles showed that knockdown of ELOVL7 in prostate cancer cells affected SVLFAs in the phospholipids and the neutral lipids, such as cholesterol ester. Focusing on cholesterol ester as a source of de novo steroid synthesis, we show that ELOVL7 affected de novo androgen synthesis in prostate cancer cells. These findings suggest that EVOLV7 could be involved in prostate cancer growth and survival through the metabolism of SVLFAs and their derivatives, could be a key molecule to elucidate the association between fat dietary intake and prostate carcinogenesis, and could also be a promising molecular target for development of new therapeutic or preventive strategies for prostate cancers. [Cancer Res 2009;69(20):8133–40]
The Glass Is Half Full: Evidence for Efficacy of Alcohol-Wise at One University But Not the Other

This research extends the growing literature about online alcohol prevention programs for first-year college students. Two independent randomized control studies, conducted at separate universities, evaluated the short-term effectiveness of Alcohol-Wise, an online alcohol prevention program not previously studied. It was hypothesized the prevention program would increase alcohol knowledge and reduce alcohol consumption, including high-risk alcohol-related behaviors, among first-year college students. At both universities, the intervention significantly increased alcohol-related knowledge. At one university, the prevention program also significantly reduced alcohol consumption and high-risk drinking behaviors, such as playing drinking games, heavy drinking, and extreme ritualistic alcohol consumption. Implications for the use of online alcohol prevention programs and student affairs are discussed.
The Effect of Working Capital Management on Firm's Profitability: Evidence from Istanbul Stock Exchange

Working capital management is an extremely essential issue for the healthy conduct of the sustainability of a business. The active and day-to-day nature of the short term business emporium, the ongoing necessity to substitute current assets and in the meantime to liquidate current liabilities clearly demonstrates the significance of working capital management and therefore the essential duty the financial executives carry. While an optimal strategy of working capital management is expected to positively contribute not only to the profitability of a firm but also its value; there is a trade-off between the liquidity level the firm is carrying and its profitability. The direct effect of working capital management on profitability and liquidity of firms clearly demonstrates the significance working capital management has in a firm and consequently the objective of this chapter is to find whether or not working capital management, i.e. cash conversion cycle has an effect on profitability for the publicly listed companies in Turkey using panel regression analysis.
How to negotiate with a liar

People, including negotiators, lie every day, so when you’re trying to make a deal, it’s important to defend against deception. The best strategy, says the author, is to focus not on detecting lies but on preventing them. She outlines five tactics that research has shown to be effective: Encourage reciprocity. You can build trust and prompt other parties to disclose strategic information by sharing information yourself. Ask the right questions. Negotiators often lie by omission, keeping mum about relevant facts, but if directly asked, they are more likely to respond honestly. Watch for dodging. Don’t let your counterparts sidestep your questions—write them down in advance, take notes on the answers, and make sure you get the information you’re seeking. Don’t dwell on confidentiality. Studies show that the more you reassure others that you’ll protect their privacy, the more guarded and apt to lie they become. So be nonchalant when discussing sensitive topics. Cultivate leaks. People often reveal information unwittingly, so listen carefully for any slips and try indirect approaches to gaining information. INSET: In the Hot Seat: Handling Tough Questions Honestly
Advances and development in transdermal drug delivery system-A review

It is one of the best pharmaceutical dosage forms for those patients, they cannot take medicaments orally. Transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems (NDDS). On the application of Transdermal patches, the delivery of the drug across dermis gives the systemic effect. TDDS is costly alternative to conventional formulation. It is also important due to its unique advantage. Controlled absorption, more uniform plasma levels, improved bioavailability, reduced side effects, painless and simple application and flexibility of terminating drug administration by simply removing the patch from the skin are some of the potential advantages of transdermal drug delivery. Development of controlled release transdermal dosage form is a complex process involving extensive efforts. This review article describes the methods of preparation of different types of transdermal patches. In addition, the various methods of evaluation of transdermal dosage form and Advance Development in TDDS have also been reviewed.
Postmerger Strategies Healthcare Business Leaders Use to Influence Employee Engagement and Satisfaction

Postmerger Strategies Healthcare Business Leaders Use to Influence Employee Engagement and Satisfaction by Angie Kovarik MBA, American Intercontinental University, 2008 BBA, American Intercontinental University, 2007 Doctoral Study Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Business Administration Walden University Aug 2016 Abstract Mergers and acquisitions (MA it has been very much appreciated. Thank you Dr. Freda Turner for leading as a true professional and role model. Finally, I thank my classmates from Dr. Chermack’s 9000 group. The encouragement and motivation exchanged amongst this group is like no other. It is a family that spans the globe, and I wish nothing but the best for every one of you.
Effects of dopamine agonists and antagonists on murine melanoma: Correlation with dopamine binding activity

The biosynthetic pathway producing melanin is present in many melanomas. Previous investigations have suggested that pharmacologic levels of intermediates in this pathway (L‐dopa, dopamine, and their analogues) may inhibit macromolecular synthesis in some tissue culture melanoma cell lines and prolong survival in tumor‐bearing mice. Recently, a potent antidopamine drug (pimozide) has been developed. This study was designed to investigate the effects of these drugs on marine melanomas and to correlate effects on macromolecular synthesis with competitive dopamine binding activity (receptors) and melanin synthesis. Three murine melanomas (F1, F10, B16) were studied. The amelanotic B16 cell line showed no inhibition by dopa, dopamine, or pimozide when assayed for 14C‐leu or 3H‐TdR incorporation. Using a competitive binding assay, only low levels of dopamine binding were present. The very melanotic F1 cell line showed no inhibition by dopa or dopamine, but pimozide inhibited 14C‐leu and 3H‐TdR incorporation in a dose‐response fashion; 50% inhibition was noted at 10−9 M concentration with no loss in cell viability as tested by trypan blue exclusion or cell counting. Competitive dopamine binding was present (19 pmoles per g of wet tissue) with a Kd of 0.2 nM, figures approximating those seen in normal dog caudate nucleus controls. The F10 line, with melanin production between the B16 and F1, was intermediate in terms of inhibition of 14C‐leu and 3H‐TdR incorporation and dopamine binding. Purified melanin did not bind and, thus, does not appear to explain these binding results. These data suggest that pimozide, a drug which is a potent dopamine antagonist, may inhibit 14C‐leu and 3H‐TdR incorporation in murine melanoma cells and that competitive dopamine binding (receptor) appears to correlate with this inhibition. This drug and the dopamine binding assay may be useful in the study of human melanoma.
GABAB Receptor Association with the PDZ Scaffold Mupp1 Alters Receptor Stability and Function*

γ-Aminobutyric acid, type B (GABAB) receptors are heterodimeric G protein-coupled receptors that mediate slow inhibitory synaptic transmission in the central nervous system. To identify novel interacting partners that might regulate GABAB receptor (GABABR) functionality, we screened the GABABR2 carboxyl terminus against a recently created proteomic array of 96 distinct PDZ (PSD-95/Dlg/ZO-1 homology) domains. The screen identified three specific PDZ domains that exhibit interactions with GABABR2: Mupp1 PDZ13, PAPIN PDZ1, and Erbin PDZ. Biochemical analysis confirmed that full-length Mupp1 and PAPIN interact with GABABR2 in cells. Disruption of the GABABR2 interaction with PDZ scaffolds by a point mutation to the carboxyl terminus of the receptor dramatically decreased receptor stability and attenuated the duration of GABAB receptor signaling. The effects of mutating the GABABR2 carboxyl terminus on receptor stability and signaling were mimicked by small interference RNA knockdown of endogenous Mupp1. These findings reveal that GABAB receptor stability and signaling can be modulated via GABABR2 interactions with the PDZ scaffold protein Mupp1, which may contribute to cell-specific regulation of GABAB receptors in the central nervous system.
Genetic Diversity of Escherichia coli Isolated from Urban Rivers and Beach Water

ABSTRACT Repetitive element anchored PCR was used to evaluate the genetic profiles of Escherichia coli isolated from surface water contaminated with urban stormwater, sanitary sewage, and gull feces to determine if strains found in environmental samples reflect the strain composition of E. coli obtained from host sources. Overall, there was less diversity in isolates collected from river and beach sites than with isolates obtained from human and nonhuman sources. Unique strain types comprised 28.8, 29.2, and 15.0% of the isolate data sets recovered from stormwater, river water, and beach water, respectively. In contrast, 50.4% of gull isolates and 41.2% of sewage isolates were unique strain types. River water, which is expected to contain E. coli strains from many diffuse sources of nonpoint source pollution, contained strains most closely associated with other river water isolates that were collected at different sites or on different days. However, river sites impacted by sewage discharge had approximately 20% more strains similar to sewage isolates than did sites impacted by stormwater alone. Beach sites with known gull fecal contamination contained E. coli most similar to other beach isolates rather than gull isolates collected at these same sites, indicating underrepresentation of possible gull strains. These results suggest large numbers of strains are needed to represent contributing host sources within a geographical location. Additionally, environmental survival may influence the composition of strains that can be recovered from contaminated waters. Understanding the ecology of indicator bacteria is important when interpreting fecal pollution assessments and developing source detection methodology.
EEG based emotion monitoring using wavelet and learning vector quantization

Emotional identification is necessary for example in Brain Computer Interface (BCI) application and when emotional therapy and medical rehabilitation take place. Some emotional states can be characterized in the frequency of EEG signal, such excited, relax and sad. The signal extracted in certain frequency useful to distinguish the three emotional state. The classification of the EEG signal in real time depends on extraction methods to increase class distinction, and identification methods with fast computing. This paper proposed human emotion monitoring in real time using Wavelet and Learning Vector Quantization (LVQ). The process was done before the machine learning using training data from the 10 subjects, 10 trial, 3 classes and 16 segments (equal to 480 sets of data). Each data set processed in 10 seconds and extracted into Alpha, Beta, and Theta waves using Wavelet. Then they become input for the identification system using LVQ three emotional state that is excited, relax, and sad. The results showed that by using wavelet we can improve the accuracy of 72% to 87% and number of training data variation increased the accuracy. The system was integrated with wireless EEG to monitor emotion state in real time with change each 10 seconds. It takes 0.44 second, was not significant toward 10 seconds.
E-Government Challenges in European Countries

To what extent and in which direction does the recent so-called “shift from e-Government to e-Governance systems” take place in European governments? Much has been claimed and written about the influence of e-Government on the modernization and growth of public sector initiatives in Europe. Little is known, however, about how the shift from e-Government to e-Governance takes place in European governments. In particular, in this chapter, an overview of both challenges and advantages of implementing e-Governance strategies is presented, by examining how closely and critically intertwined e-Government and e-Governance are in European countries, with particular reference to the emerging ones. In fact, according to the European Commission indexes, European countries have been split in two groups: Pioneers (P) that are the “best-in-class” EU members, and Followers (F) that have only recently undertaken their path towards the ICT and e-government implementation and still have to foster the e-governance development. The authors judge this comparison as particular instructive in order to draw out some lessons that can be learnt by emerging countries about how to face these challenges.
Stress-induced haematopoietic stem cell proliferation: new roles for p38α and purine metabolism.

Haematopoietic stem cells (HSCs) are self-renewing cells that sustain the production of all blood and immune cell lineages throughout life by residing at the top of the haematopoietic hierarchy. They first arise early in embryogenesis and their site of action changes during development. In adult mammals, HSCs reside in the bone marrow within a complex microenvironment termed the HSC niche (1). They are defined by their ability to completely repopulate the entire blood system of a recipient, resulting in the formation of red blood cells, megakaryocytes, myeloid cells and lymphocytes, and in order to do this they are able to undergo asymmetric division where one daughter cell remains as a HSC whilst the other becomes committed to differentiation (2). In the bone marrow, to prevent exhaustion and to preserve their ability to self-renew, HSCs are normally maintained in a dormant or quiescent state, from which they can be rapidly awakened in response to haematological stress (3). How this is regulated is an important issue and in a recent issue of Cell Stem Cell , Karigane et al . have shed new light on how the p38 MAPK pathway promotes stress-induced proliferation in HSCs (4).
Fast shadow removal algorithm for river garbage pollution monitoring system

In this paper, a fast shadow removal algorithm developed and implemented for river garbage pollution monitoring is reported. The algorithm is a modification of Retinex PDE shadow removal. In usual serial approach way, although giving satisfaction results in removing shadow in river image, Retinex PDE requires much computation tasks. In order to make it run faster, a parallel processing approach was applied. The parallel processing based shadow removal system had been developed using NVIDIA CUDA platform. The shadow removed images will then be processed using image segmentation. The segmentation process will separate between river and non-river (garbage) part in image. To analyze the accuracy of river and garbage separation, the percentages of garbage part in the segmented shadow removed image are compared with the percentage of garbage part obtained from ground truth image. The speed of computation between serial approach and parallel approach of shadow removal are also be compared and analyzed.
Coronary artery disease and the acute coronary syndrome.

Coronary Artery Disease and Acute Coronary Syndrome Coronary Artery Disease and Acute Coronary Syndrome develop as a result of atherosclerosis. Atherosclerosis begins as a soft deposit of fat that hardens as it ages. With coronary artery disease and acute coronary syndrome, these deposits are found in the coronary arteries. They lead to a decreased oxygen supply to the heart tissue which can cause permanent damage. Cardiovascular disease is the major cause of death in the United States.
ESTIMATION FOR ADAPTIVE RADAR CLUTTER CANCELLATION

Adaptive waveform design for radar clutter cancellation requires knowledge of the rank of the clutter subspace. In this paper, we compare the computed clutter subspace rank, r, using three methods: (i) the exponentially embedded family (EEF) estimator, (ii) Rissanen’s minimum description length (MDL) estimator, and (iii) the statistical ranking and selection method (CWA).