Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantification of DNA Damage in Different Tissues in Rats with Heart Failure

Background Chronic heart failure (CHF) is a complex syndrome which comprises structural and functional alterations in the heart in maintaining the adequate blood demand to all tissues. Few investigations sought to evaluate oxidative DNA damage in CHF. Objective To quantify the DNA damage using the comet assay in left ventricle (LV), lungs, diaphragm, gastrocnemius and soleus in rats with CHF. Methods Twelve male Wistar rats (300 to 330 g) were selected for the study: Sham (n = 6) and CHF (n = 6). The animals underwent myocardial infarction by the ligation of the left coronary artery. After six weeks, the animals were euthanized. It was performed a cell suspension of the tissues. The comet assay was performed to evaluate single and double strand breaks in DNA. Significance level (p) considered < 0.05. Results The CHF group showed higher values of left ventricle end-diastolic pressure (LVEDP), pulmonary congestion, cardiac hypertrophy and lower values of maximal positive and negative derivatives of LV pressure, LV systolic pressure (p < 0.05). CHF group showed higher DNA damage (% tail DNA, tail moment and Olive tail moment) compared to Sham (p < 0.001). The tissue with the highest damage was the soleus, compared to LV and gastrocnemius in CHF group (p < 0.05). Conclusion Our results indicates that the CHF affects all tissues, both centrally and peripherically, being more affected in skeletal muscle (soleus) and is positively correlated with LV dysfunction.
Variability in the cytokine synthesis by human dendritic cells in response to different Aggregatibacter actinomycetemcomitans serotypes

-1 -10 -2 con los serotipos a, b y c de A. Actinomycetemcomitans. Mediante PCR y ELISA se evaluaron los niveles de expresion y secrecion de citoquinas. Resultados: En las celulas dendriticas, la produccion de citoquinas fue diferente ante los distintos serotipos de A. actinomycetemcomitans, con mayores niveles de secrecion de IL-1β, IL-6, IL-12, IL-23, IFN-γ y TNF-α cuando el microorganismo estimulante fue la cepa ATCC ® 43718™ (serotipo b). Conclusion: El serotipo b de A. actinomycetemcomitans posee un mayor potencial inmuno-estimulador de celulas dendriticas comparado con los otros serotipos bacterianos y potencialmente contribuiria a inducir un patron de respuesta inmune tipo Th1 y/o Th17 durante las periodontitis. Rev. Clin. Periodoncia Implantol. Rehabil. Oral Vol. 6(2); 57-62, 2013. Palabras clave: Celulas dendriticas, citoquinas, Aggregatibacter actinomycetemcomitans.
Machine-knitted washable sensor array textile for precise epidermal physiological signal monitoring

A triboelectric all-textile sensor with high pressure sensitivity and comfort was been developed for health monitoring. Wearable textile electronics are highly desirable for realizing personalized health management. However, most reported textile electronics can either periodically target a single physiological signal or miss the explicit details of the signals, leading to a partial health assessment. Furthermore, textiles with excellent property and comfort still remain a challenge. Here, we report a triboelectric all-textile sensor array with high pressure sensitivity and comfort. It exhibits the pressure sensitivity (7.84 mV Pa−1), fast response time (20 ms), stability (>100,000 cycles), wide working frequency bandwidth (up to 20 Hz), and machine washability (>40 washes). The fabricated TATSAs were stitched into different parts of clothes to monitor the arterial pulse waves and respiratory signals simultaneously. We further developed a health monitoring system for long-term and noninvasive assessment of cardiovascular disease and sleep apnea syndrome, which exhibits great advancement for quantitative analysis of some chronic diseases.
Pharmaceutical composition combining tenatoprazole and an anti-inflammatory agent

The present invention relates to a new pharmaceutical formulation. The pharmaceutical compositions of the present invention comprises a combination of tenatoprazole and nonsteroidal anti-inflammatory and cyclooctyl one or more anti-inflammatory agent is selected from the dioxygenase claim 2 inhibitors. The invention is suitable for the treatment of pain and inflammatory symptoms.
Modulation of Inflammatory Cytokine Responses to Neurosurgery and Traumatic Injury via Sympathoadrenal Activation

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. TBI elicits sympathetic nervous system (SNS) activation with massive catecholamines secretion and modulation of neuroimmune networks. Catecholamines incites cerebral and systemic immune cells to synthesize and secrete multiple proand anti-inflammatory cytokines. Our study aims to evaluate temporal changes in circulating proand anti-inflammatory cytokines Interleukin (IL)1β, tumor necrosis factor (TNF)-α, and IL-10 in association with plasma epinephrine (E) and norepinephrine (NE) levels, in traumatic brain injury (TBI) and elective neurosurgical patients. This also examines possible interrelationships between these mediators and neurological outcomes as evaluated by extended Glasgow Outcome Scale (GOSE) score. From the data gathered within this study, it was determined that high circulating catecholamine levels affect the proand anti-inflammatory cytokine balance, and patients with higher peak cytokine levels do sustain worsened neurologic outcome.
Single anastomosis (mini-) gastric bypass for the treatment of Asian type 2 diabetes mellitus

Bariatric surgery is the most efficacious therapy for morbid obesity today, and now moving from bariatric surgery to metabolic surgery for the treatment of type 2 diabetes mellitus (T2DM). Advancement in laparoscopic technique contributed to a rapid surge of the volume of bariatric surgery. However, the type of bariatric/metabolic procedures evolved over the past 60 years and is still evolving. Single anastomosis (mini-) gastric bypass (SAGB) was first proposed by Dr. Robert Rutledge in 2001. Many surgeons across the world have strong concerns to this procedure but do not perform it. Although controversy existed, tens of thousands of this procedure have been reported throughout the world with universally good results. The advantages of this procedures included technique simplicity, shorter learning curve, easy to convert and better weight loss and co-morbidities resolution. However, data about the result of SAGB specifically for the treatment of T2DM in Asian is less known. The review examines the current status, long-term result of SAGB on weight reduction and the efficacy on T2DM treatment in Asian.
Prehipertensión: la influencia del estrés psicológico en adolescentes.

The article examines the association between psychological stress (PS) and prehypertension (PH) in 690 adolescents, 260 males and 430 females, whose average age was 15.2 years (SD = 1.5). Their blood pressure (BP) was measured on separate days at school, by the oscillometric method (Dinamap) in a seating position. All of them completed a survey assessing life events and social readjustment (both scales associated with life stressors in adolescence). Participants were classified according to BP levels in prehypertensive (PH) and normotensive (N). The presence of PS was evaluated as severe stressful life events. The Chi-square test was used to study the association between PS and the presence of PH. The results showed the presence of PH in 9.2% (n = 24) in males and 3.5% (n = 15) in females, while the presence of PS ocurred in 70 males (26.9%) and 155 females (36.0%). When applied to the whole data, the Chi-square statistical test showed no association between PS and the condition of prehypertension [PH with PS = 15 vs. N with PS = 24, (P= 0.42)]. However, when subjects were classified by gender, there was a significant association between PS and PH in female adolescents [PH with PS = 9 vs N with PS = 6 (P = 0.04)]. This result suggests that, at early ages, female adolescents may be more vulnerable than males to PS as a determining factor to the condition of PH.
Are you on my wavelength? Interpersonal coordination in naturalistic conversations

Conversation between two people involves subtle non-verbal coordination but the parameters and timing of this coordination remain unclear, which limits our models of social coordination mechanisms. We implemented high-resolution motion capture of human head motion during structured conversations. Using pre-registered analyses, we quantify cross-participant wavelet coherence of head motion as a measure of non-verbal coordination, and report two novel results. First, head pitch (nodding) at 2.6 – 6.5 Hz shows below-chance coherence between people. This is driven by fast-nodding behaviour from the person listening, and is a newly defined nonverbal behaviour which may act as an important social signal. Second, head pitch movements at 0.2-1.1 Hz show above-chance coherence with a constant lag of around 600msec between a leader and follower. This is consistent with reactive (rather than predictive) models of mimicry behaviour. These results provide a step towards the quantification of real-world human behaviour and reveal mechanisms of social coordination.
Non-Conventional Deformations: Materials and Actuation

This paper reviews materials and structures displaying non-conventional deformations as a response to different actuations (e.g., electricity, heat and mechanical loading). Due to the various kinds of actuation and targeted irregular deformation modes, the approaches in the literature show great diversity. Methods are systematized and tabulated based on the nature of actuation. Electrically and mechanically actuated shape changing concepts are discussed individually for their significance, while systems actuated by heat, pressure, light and chemicals are condensed in a shared section presenting examples and main research trends. Besides scientific research results, this paper features examples of real-world applicability of shape changing materials, highlighting their industrial value.
Color Shift, Color Stability, and Post-Polishing Surface Roughness of Esthetic Resin Composites

The aim of this study was to compare color shift, color stability, and post-polishing surface roughness of esthetic restorative materials. Twenty-five disc-shaped specimens (10 mm in diameter and 2 mm in thickness) from five esthetic resin materials (Z250XT, IPS Empress-Direct, G-ænial, Vit-l-escence, and Ceram.X) were fabricated. Color shift before and immediately after light-curing (∆E0) then color stability after immersion in tea, coffee, berry juice, and distilled water were measured using a spectrophotometer. Color changes were measured after 2 (ΔE2), 4 (ΔE4), 6 (ΔE6), and 8 weeks (ΔE8). Surface roughness values (Rq) were determined using an optical profilometer after polishing using a rotary polishing system. Data were analyzed using ANOVA and multiple comparison methods at 0.05 significance level. There were no significant differences between the tested materials regarding color shift except between Vit-l-escence and Ceram.X (p = 0.033). There was no significant difference between coffee and tea solutions (p = 1.0) and between berry juice and distilled water (p = 0.15). There was no difference between the tested materials regarding Rq (p = 0.057). Ceram.X was associated with the lowest ΔE8 values overall. Tested materials were comparable regarding color shift and post-polishing surface roughness. Susceptibility to staining was dependent on the material.
Petroleomics: Tools, Challenges, and Developments.

The detailed molecular characterization of petroleum-related samples by mass spectrometry, often referred to as petroleomics, continues to present significant analytical challenges. As a result, petroleomics continues to be a driving force for the development of new ultrahigh resolution instrumentation, experimental methods, and data analysis procedures. Recent advances in ionization, resolving power, and mass accuracy, and the use of separation methods, have allowed for record levels of compositional detail to be obtained for petroleum-related samples. To address the growing size and complexity of the data generated, vital software tools for data processing, analysis, and visualization continue to be developed. The insights gained impact upon the fields of energy and environmental science and the petrochemical industry, among others. In addition to advancing the understanding of one of nature's most complex mixtures, advances in petroleomics methodologies are being adapted for the study of other sample types, resulting in direct benefits to other fields. Expected final online publication date for the Annual Review of Analytical Chemistry, Volume 13 is June 12, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Biomaterials and biocompatibility: an historical overview.

This review focuses on the characteristics and applications of biomaterials through the ages, ranging from the prehistoric times to the beginning of the era of modern medicine, which has been arbitrarily set to the middle of the 19th century, when aseptic procedures, antiseptic substances and modern anaesthetics were developed. After a brief discussion on the definition of "biomaterial" from an historical point of view and a short introduction on the general history of surgery and dentistry, each material or class of materials will be presented with references listed in chronological order and, where possible, with their real, scientifically demonstrated effects on biological tissues. Particular attention has been given to references that are nowadays considered spurious or affected by translation errors or other kinds of biases. This article is protected by copyright. All rights reserved.
Benefits of CT Scanning for the Management of Hip Arthritis and Arthroplasty.

INTRODUCTION Imaging studies for preoperative planning of total hip arthroplasty (THA) are typically obtained by two-dimensional (2D) anteroposterior radiographs. However, CT imaging has proven to be a valuable tool that may be more accurate than standard radiographs. The purpose of this review was to report on the current literature to assess the utility of CT imaging for preoperative planning of THA. Specifically, we assessed its utility in the evaluation of: 1) hip arthritis; 2) femoral head osteonecrosis; 3) implant size prediction; 4) component alignment; 5) limb length evaluation; and 6) radiation exposure. MATERIALS AND METHODS A literature search was performed using search terms "computed tomography", "radiograph", "joint" "alignment", "hip," and "arthroplasty". Our initial search returned a total of 562 results. After applying our criteria, 26 studies were included. RESULTS CT scans were found to be more accurate than radiographs in predicting implant size and alignment preoperatively and provide improved visualization of extraarticular deformities that may be essential to consider when planning a THA. Although radiation is a potential concern, newer imaging protocols have minimized the radiation to levels comparable to x-ray. CONCLUSION The current literature suggests that CT has several advantages over radiographs for preoperative planning of THA including more accurate planning of implant size, component alignment, and postoperative leg length. It is also superior to x-ray in identifying extraarticular hip deformities using the minimum effective dose for CT and the minimum scan length required by templating software. The radiation can be reduced to values similar to radiography.
Pullulan for Advanced Sustainable Body- and Skin-Contact Applications

The present review had the aim of describing the methodologies of synthesis and properties of biobased pullulan, a microbial polysaccharide investigated in the last decade because of its interesting potentialities in several applications. After describing the implications of pullulan in nano-technology, biodegradation, compatibility with body and skin, and sustainability, the current applications of pullulan are described, with the aim of assessing the potentialities of this biopolymer in the biomedical, personal care, and cosmetic sector, especially in applications in contact with skin.
Stock price prediction using principal components

The literature provides strong evidence that stock price values can be predicted from past price data. Principal component analysis (PCA) identifies a small number of principle components that explain most of the variation in a data set. This method is often used for dimensionality reduction and analysis of the data. In this paper, we develop a general method for stock price prediction using time-varying covariance information. To address the time-varying nature of financial time series, we assign exponential weights to the price data so that recent data points are weighted more heavily. Our proposed method involves a dimension-reduction operation constructed based on principle components. Projecting the noisy observation onto a principle subspace results in a well-conditioned problem. We illustrate our results based on historical daily price data for 150 companies from different market-capitalization categories. We compare the performance of our method to two other methods: Gauss-Bayes, which is numerically demanding, and moving average, a simple method often used by technical traders and researchers. We investigate the results based on mean squared error and directional change statistic of prediction, as measures of performance, and volatility of prediction as a measure of risk.
SP1-induced lncRNA LINC00689 overexpression contributes to osteosarcoma progression via the miR-655/SOX18 axis.

OBJECTIVE Many findings have demonstrated long noncoding RNAs (lncRNAs) as crucial regulatory molecules in the progression of osteosarcoma. The aim of this study was to explore the roles and mechanisms of LncRNA LINC00689 (LINC00689) in osteosarcoma. PATIENTS AND METHODS Differential levels of LINC00689 and miR-655 in osteosarcoma samples and cell lines were analyzed by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The associations between LINC00689 expression and prognostic significance of osteosarcoma patients were analyzed using a series of statistical assays. Loss-of-function and gain-of-function assays were performed to investigate the role of LINC00689 in proliferation and metastasis in vitro. Bioinformatic assays, Luciferase report assays, and rescue assays were applied to illustrate the ceRNA mechanism network of LINC00689/miR-655/SOX18. RESULTS We found that LINC00689 expression was distinctly upregulated in osteosarcoma specimens and cell lines. MiR-655 displayed a trend of remarkably decreased expression in osteosarcoma tissues. In addition, we showed that LINC00689 could specifically interact with the promoter of SP1 and activate LINC00689 transcription. Further clinical studies indicated that higher levels of LINC00689 were associated with advanced clinical stage, positively distant metastasis, and unfavorable clinical outcome. Functional studies revealed that the knockdown of LINC00689 suppressed the proliferation, migration, and invasion of osteosarcoma cells, and promoted apoptosis. Final mechanistic investigations confirmed that upregulation of LINC00689 competitively bound to miR-655 that prevented SOX18 from miRNA-mediated degradation, thus facilitating osteosarcoma progression. CONCLUSIONS All our findings suggested that SP1-induced upregulation of LINC00689 promoted osteosarcoma progression by regulating miR-655/ SOX18 axis, which provided a novel insight for osteosarcoma tumorigenesis.
The Impact of Orofacial Appearance on Oral Health Related Quality of Life: A Systematic Review.

Esthetics in the orofacial region is important for perceived oral health and a common reason for treatment of discoloured, missing or crowded teeth. As one of the fundamental bricks of a patient's oral health, changes in the domain of orofacial esthetics resides within the Oral Health Related Quality of Life (OHRQoL) of an individual. Four main dimensions, Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact, are suggested to cover the concept of OHRQoL. The aim of this systematic review was to map the impact from oral conditions with principal impact on the Orofacial Appearance dimension of OHRQoL (PROSPERO: CRD42017064033). Publications were included if they reported Oral Health Impact Profile (OHIP) mean or median domain scores for patients with esthetic treatment need relating to tooth wear, orthodontics, orthognathic surgery, frontal tooth loss or tooth whitening. A search in PubMed (Medline), EMBASE, Cochrane, CINAHL, and PsycINFO June 8, 2017 and updated January 14, 2019, identified 2,104 abstracts. After screening of abstracts, 1,607 articles were reviewed in full text and 33 articles included. These 33 articles reported OHIP-data for 9,409 patients grouped in 63 patient populations. Median orofacial appearance impact scores on a standardized 0 to 8 scale, for populations with treatment need relating to tooth wear, orthodontics, orthognathic surgery, frontal tooth loss and tooth whitening, ranged from 0.13 for tooth wear to 3.04 for tooth whitening populations. In conclusion, a moderate impact for the Orofacial Appearance dimension of OHRQoL was found in patients with different conditions with esthetically related treatment need.
A Contagious Other? Exploring the Public’s Appraisals of Contact with ‘Mental Illness’

Mental illness has recurrently been found to be Othered by the lay public, although few researchers have examined the affective and implicit processes involved. To explore this, we triangulated facial electromyography (EMG), self-reports, and individual interview data, finding participants to Other mental illness, a process that involved disgust, fear and pity. Furthermore, mental illness was considered to have the potential to permeate, posing a contagious threat. This research highlights the need to fully explore the forms of understanding, which maintain mental-health related stigma, including beliefs about contamination, and the implications this may have for the design of anti-stigma campaigns.
Dynamic prediction of time to a clinical event with sparse and irregularly measured longitudinal biomarkers

In clinical research and practice, landmark models are commonly used to predict the risk of an adverse future event, using patients' longitudinal biomarker data as predictors. However, these data are often observable only at intermittent visits, making their measurement times irregularly spaced and unsynchronized across different subjects. This poses challenges to conducting dynamic prediction at any post‐baseline time. A simple solution is the last‐value‐carry‐forward method, but this may result in bias for the risk model estimation and prediction. Another option is to jointly model the longitudinal and survival processes with a shared random effects model. However, when dealing with multiple biomarkers, this approach often results in high‐dimensional integrals without a closed‐form solution, and thus the computational burden limits its software development and practical use. In this article, we propose to process the longitudinal data by functional principal component analysis techniques, and then use the processed information as predictors in a class of flexible linear transformation models to predict the distribution of residual time‐to‐event occurrence. The measurement schemes for multiple biomarkers are allowed to be different within subject and across subjects. Dynamic prediction can be performed in a real‐time fashion. The advantages of our proposed method are demonstrated by simulation studies. We apply our approach to the African American Study of Kidney Disease and Hypertension, predicting patients' risk of kidney failure or death by using four important longitudinal biomarkers for renal functions.