Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing Analysis Method of Optimum Portfolio with Value at Risk – Sharia’ Complian Asset Pricing Model (VaR-SCAPM) Approach

Capital Asset Pricing Model (CAPM) in portfolio analysis used the concept of interest rates in the calculation. Interest rates in the concept of Islam financial are forbidden as classified to usury. Therefore, an optimum portfolio analysis tool was developed by replacing the concept of interest rates to zakat rates combined with a Value at Risk analysis tool named Value at Risk–sharia’ Capital Asset Pricing Model (VaR-SCAPM (Z). Its implementation in the sharia’ capital market in Indonesia of January 2011 to August 2016 was obtained by three stocks of Jakarta Islamic Index (JII) of compiler the optimum portfolio of VaR-SCAPM (Z) with proportions 20.71% of KLBF, 38.95% of TLKM, and 40.34% of UNVR. As for the monthly profit rate of 1.75% and the greatest possible loss using VaR-95% of 6.65%.
Ectopic Expression of a Cecropin Transgene in the Human Malaria Vector Mosquito Anopheles gambiae (Diptera: Culicidae): Effects on Susceptibility to Plasmodium

Abstract Genetically altering the disease vector status of insects using recombinant DNA technologies is being considered as an alternative to eradication efforts. Manipulating the endogenous immune response of mosquitoes such as the temporal and special expression of antimicrobial peptides like cecropin may result in a refractory phenotype. Using transgenic technology a unique pattern of expression of cecropin A (cecA) in Anopheles gambiae was created such that cecA was expressed beginning 24 h after a blood meal in the posterior midgut. Two independent lines of transgenic An. gambiae were created using a piggyBac gene vector containing the An. gambiae cecA cDNA under the regulatory control of the Aedes aegypti carboxypeptidase promoter. Infection with Plasmodium berghei resulted in a 60% reduction in the number of oocysts in transgenic mosquitoes compared with nontransgenic mosquitoes. Manipulating the innate immune system of mosquitoes can negatively affect their capacity to serve as hosts for the development of disease-causing microbes.
Making use of elicited confidence ratings of the SP survey in a joint RP-SP model: a case study of commuting mode choices for TDM evaluations

ABSTRACT The paper proposes a joint econometric model to investigate the effects of inertia; elicited confidence rating on SP choices and socio-economic variables on the choice model parameter estimates. The proposed model is estimated empirically by using a dataset collected in the Region of Peel, Ontario, which was designed to collect data for evaluating employer-based Travel Demand Management (TDM) strategy evaluation. Empirical models reveal that the accommodation of inertia effects and socio-economic attributes in the joint RP-SP model mainly improves the goodness-of-fit of the choice model. However, capturing endogeneity between SP choice and elicited confidence rating improves the efficiency of parameter estimates by increasing the statistical significance of the choice model parameters. The paper shows that there is the profound benefit of collecting confidence rating information in SP choice experiment and exploiting such information to enhance choice model parameter estimates.
Phase I trial of 5-fluorouracil and recombinant alpha 2a-interferon in patients with advanced colorectal carcinoma.

We have previously shown that the combination of 5-fluorouracil (5-FUra) and recombinant alpha-2a-interferon (rIFN-alpha-2a) produced objective responses in 23 of 32 (63%) previously untreated patients with advanced colorectal carcinoma. Because in vitro data suggest that rIFN-alpha-2a modulates the cytotoxic effects of 5FUra in a concentration-dependent manner, a phase I clinical trial was initiated to determine the maximum tolerated dose of rIFN-alpha 2a when administered in combination with 5FUra. A total of 27 patients with advanced colorectal carcinoma were enrolled. The median age was 64 years, and the median performance status was 1. A total of 18 patients had no prior chemotherapy and 19 no prior 5FUra. 5FUra was administered at 750 mg/m2/day by continuous i.v. infusion for 5 days, followed by weekly bolus therapy. rIFN-alpha 2a was administered at 6, 9, 12, 15, or 18 x 10(6) units s.c. beginning on day 1. The dose-limiting toxicity of this regimen was fatigue, resulting in a decrease in performance status, and this was the only toxicity that correlated with increasing dose of rIFN-alpha 2a. Eastern Cooperative Oncology Group grade 3-4 toxicities included leukopenia (6), thrombocytopenia (2), anemia (4), stomatitis (4), diarrhea (4), neurological (2), infection (2), and allergy (2). Three quarters of the patients required interruption of therapy or dose reductions of either 5FUra or rIFN-alpha 2a for toxicity. Among the patients with measurable disease who were previously untreated with 5FUra, 5 of 9 at the lowest dose levels achieved an objective response, including one pathological complete responder, whereas 0 of 9 at the three highest dose levels responded. Among patients previously treated with 5FUra, only 1 achieved an objective response. We conclude that the maximum tolerated dose of rIFN-alpha 2a, when administered with 5FUra as above, is 15-18 x 10(6) units; however, the efficacy of this regimen does not appear to be related to the dose intensity of rIFN-alpha 2a, and future regimens should employ a lower dose, intermittent schedule of rIFN-alpha 2a, which may be better tolerated.
Summary of evidence-based guideline: Periprocedural management of antithrombotic medications in patients with ischemic cerebrovascular disease

Objective: To assess evidence regarding periprocedural management of antithrombotic drugs in patients with ischemic cerebrovascular disease. The complete guideline on which this summary is based is available as an online data supplement to this article. Methods: Systematic literature review with practice recommendations. Results and recommendations: Clinicians managing antithrombotic medications periprocedurally must weigh bleeding risks from drug continuation against thromboembolic risks from discontinuation. Stroke patients undergoing dental procedures should routinely continue aspirin (Level A). Stroke patients undergoing invasive ocular anesthesia, cataract surgery, dermatologic procedures, transrectal ultrasound–guided prostate biopsy, spinal/epidural procedures, and carpal tunnel surgery should probably continue aspirin (Level B). Some stroke patients undergoing vitreoretinal surgery, EMG, transbronchial lung biopsy, colonoscopic polypectomy, upper endoscopy and biopsy/sphincterotomy, and abdominal ultrasound–guided biopsies should possibly continue aspirin (Level C). Stroke patients requiring warfarin should routinely continue it when undergoing dental procedures (Level A) and probably continue it for dermatologic procedures (Level B). Some patients undergoing EMG, prostate procedures, inguinal herniorrhaphy, and endothermal ablation of the great saphenous vein should possibly continue warfarin (Level C). Whereas neurologists should counsel that warfarin probably does not increase clinically important bleeding with ocular anesthesia (Level B), other ophthalmologic studies lack the statistical precision to make recommendations (Level U). Neurologists should counsel that warfarin might increase bleeding with colonoscopic polypectomy (Level C). There is insufficient evidence to support or refute periprocedural heparin bridging therapy to reduce thromboembolic events in chronically anticoagulated patients (Level U). Neurologists should counsel that bridging therapy is probably associated with increased bleeding risks as compared with warfarin cessation (Level B). The risk difference as compared with continuing warfarin is unknown (Level U).
Regulators Encoded in the Escherichia coli Type III Secretion System 2 Gene Cluster Influence Expression of Genes within the Locus for Enterocyte Effacement in Enterohemorrhagic E. coli O157:H7

ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) O157:H7 subverts host cells through a type III secretion system encoded by the locus for enterocyte effacement (LEE). Genome sequencing of this pathotype revealed the existence of a gene cluster encoding components of a second cryptic type III secretion system, E. coli type III secretion system 2 (ETT2). Recently, we showed that the ETT2 gene cluster is present in whole or in part in the majority of E. coli strains but is unable to encode a functional secretion system in most strains, including EHEC O157:H7. However, here we show that mutational inhibition of two regulatory genes (ECs3720 or etrA and ECs3734 or eivF) from the ETT2 cluster in EHEC O157:H7 leads to greatly increased secretion of proteins encoded by the LEE and to increased adhesion to human intestinal cells. Studies in which transcriptional fusions and microarrays were used indicated that EtrA and EivF exert profound negative effects on gene transcription within the LEE. Consistent with these observations, expression of these regulators in an EHEC O26:H- strain led to suppression of protein secretion under LEE-inducing conditions. These findings provide fresh examples of the influence of mobile genetic elements on regulation of the LEE and of cross talk between type III secretion system gene clusters. In addition, they provide a cautionary tale because they show that the effects of regulatory genes can outlive widespread decay of other genes in a functionally coherent gene cluster, a phenomenon that we have named the “Cheshire cat effect. ” It also seems likely that variations in the ETT2 regulator repertoire might account for strain-to-strain variation in secretion of LEE-encoded proteins.
Addressing security issues in ADS-B with robust two dimensional generalized sidelobe canceller

One of the main reasons why ADS-B (Automatic Dependant Surveillance — Broadcast) has not been accepted as main source of surveillance information for Air Traffic Control (ATC) systems is its relative vulnerability against false target position reports. To remediate the issue, today's systems usually have independent surveillance system verifying the correctness of the ADS-B messages. This will make the overall air surveillance system complex and expensive. A thorough overview about the ADS-B security issues and possible realistic solutions are given in [1]. We will propose an alternative solution based on two dimensional beamforming algorithm. It will be based on Robust Generalized Sidelobe Canceller which uses Slepian sequences to address this problem. Potential other applications of proposed algorithm is Massive MIMO or any other communication system that needs simultaneous data transmission between spatially segregated nodes.
Relationship between anaemia management at haemodialysis initiation and patient prognosis

It has been suggested that anaemia management during a transition period to haemodialysis could influence prognosis. In this paper, we have conducted a retrospective investigation on how Hb levels at haemodialysis initiation in patients with chronic kidney disease (CKD) influence the risk of cerebral infarction and cardiovascular events.
Thawing Procedures and the Time Course of Clotting Factor Activity in Fresh-Frozen Plasma: A Controlled Laboratory Investigation

BACKGROUND:In this study, we evaluated the effects of the thawing process of 2 commercially available devices on the activity of clotting factors, inhibitors and activation markers of the hemostatic system in fresh-frozen plasma (FFP). In an experimental procedure, FFP was thawed under running warm water at 42°C. METHODS:Plasma of 20 healthy donors was sampled, separated, and distributed in 3 plasma bags. Within 2 h after sampling plasma bags was frozen at a temperature of −30°C to −40°C and stored for at least 8 wk. After sampling (baseline) as well as immediately and 1, 2, 4, and 6 h after thawing, the activity of FV, FVII, FVIII, fibrinogen, fibrin monomers (FM), d-dimers (DD), α2-antiplasmin (α2-AP), and protein S (PS) was determined from each plasma bag. RESULTS:From 1 h to 6 h after thawing, no significant differences in the activity of the investigated coagulation markers dependent on the thawing procedure were found. However, immediately after thawing and independent of the thawing procedure, the activity of FVII was significantly decreased (P < 0.01), whereas FM were significantly increased (P = 0.001). CONCLUSION:The thawing procedures studied exhibited no significant influence on activity and stability of the investigated markers of coagulation over the study period. The decreased activity of FVII and the clinical significance of the increase in FM require further research.
Aggregation of population‐based genetic variation over protein domain homologues and its potential use in genetic diagnostics

Whole exomes of patients with a genetic disorder are nowadays routinely sequenced but interpretation of the identified genetic variants remains a major challenge. The increased availability of population‐based human genetic variation has given rise to measures of genetic tolerance that have been used, for example, to predict disease‐causing genes in neurodevelopmental disorders. Here, we investigated whether combining variant information from homologous protein domains can improve variant interpretation. For this purpose, we developed a framework that maps population variation and known pathogenic mutations onto 2,750 “meta‐domains. ” These meta‐domains consist of 30,853 homologous Pfam protein domain instances that cover 36% of all human protein coding sequences. We find that genetic tolerance is consistent across protein domain homologues, and that patterns of genetic tolerance faithfully mimic patterns of evolutionary conservation. Furthermore, for a significant fraction (68%) of the meta‐domains high‐frequency population variation re‐occurs at the same positions across domain homologues more often than expected. In addition, we observe that the presence of pathogenic missense variants at an aligned homologous domain position is often paired with the absence of population variation and vice versa. The use of these meta‐domains can improve the interpretation of genetic variation.
Virtualized Control Over Fog: Interplay Between Reliability and Latency

This paper introduces an analytical framework to investigate optimal design choices for the placement of virtual controllers along the cloud-to-things continuum. The main application scenarios include low-latency cyber-physical systems in which real-time control actions are required in response to the changes in states of an Internet of Things (IoT) node. In such cases, deploying controller software on a cloud server is often not tolerable due to delay from the network edge to the cloud. Hence, it is desirable to trade reliability with latency by moving controller logic closer to the network edge. Modeling the IoT node as a dynamical system that evolves linearly in time with quadratic penalty for state deviations, recursive expressions for the optimum control policy and the resulting minimum cost value are obtained by taking virtual fog controller reliability and response time latency into account. Our results indicate that latency is more critical than reliability in provisioning virtualized control services over fog endpoints, as it determines the swiftness of the fog control system as well as the timeliness of state measurements. Based on a drone trajectory tracking model, an extensive simulation study is also performed to illustrate the influence of reliability and latency on the control of autonomous vehicles over fog.
Long term follow‐up of patients with medullary carcinoma of the thyroid

All patients with medullary carcinoma of the thyroid (MCT) diagnosed in Sweden during 1959 through 1981 were identified. There were 113 males and 134 females with a mean age of 51.6 years (range, 11‐85 years). The cohort was followed with regard to survival to identify prognostic factors. The results 5 and 10 years after diagnosis have been presented previously.
Multivariate Calibration Approach for Quantitative Determination of Cell-Line Cross Contamination by Intact Cell Mass Spectrometry and Artificial Neural Networks

Cross-contamination of eukaryotic cell lines used in biomedical research represents a highly relevant problem. Analysis of repetitive DNA sequences, such as Short Tandem Repeats (STR), or Simple Sequence Repeats (SSR), is a widely accepted, simple, and commercially available technique to authenticate cell lines. However, it provides only qualitative information that depends on the extent of reference databases for interpretation. In this work, we developed and validated a rapid and routinely applicable method for evaluation of cell culture cross-contamination levels based on mass spectrometric fingerprints of intact mammalian cells coupled with artificial neural networks (ANNs). We used human embryonic stem cells (hESCs) contaminated by either mouse embryonic stem cells (mESCs) or mouse embryonic fibroblasts (MEFs) as a model. We determined the contamination level using a mass spectra database of known calibration mixtures that served as training input for an ANN. The ANN was then capable of correct quantification of the level of contamination of hESCs by mESCs or MEFs. We demonstrate that MS analysis, when linked to proper mathematical instruments, is a tangible tool for unraveling and quantifying heterogeneity in cell cultures. The analysis is applicable in routine scenarios for cell authentication and/or cell phenotyping in general.
VBalance: A selection policy of virtual machines for load balancing in cloud computing

Cloud computing is a new computing paradigm, in which the data processing and data storage are offered to customers similar to services accessed over the Internet. These services are represented by Virtual Machines (VMs) which are hosted by real servers located in large data centers. The Virtual Machines share the physical resources offered by servers. The growing demand for solutions related to Cloud has resulted in greater investments in electrical power for service providers. Today, this financial cost represents one of the greatest expenditures incurred by maintaining such data centers. Therefore, solutions have been proposed to minimize power expenditure while maintaining maximum care with requirements demanded by customers. This work presents a selection policy project utilized for the balance of workloads among servers in a data center. The proposed policy will address power issues during its selection process. The VBalance policy will select for migration, the VM that contributes most to the power consumption of the server by using the Multiple Linear Regression (MLR) model. Furthermore, a comparative analysis is made of the proposed solution with other existing models, in order to evaluate the performance.
T-lymphocyte subpopulations in tuberculosis.

BACKGROUND Tuberculosis is associated with both qualitative and quantitative defects in the cell mediated immune response. The changes that occur in the lymphocyte profile in blood in children with tuberculosis are not well understood. DESIGN Prospective study. SETTING Referral hospitals. METHODS Lymphocyte subpopulations were determined by flow cytometry in 17 healthy tuberculin positive children, in 22 children with newly diagnosed pulmonary tuberculosis and in 8 of these children after antituberculosis therapy. RESULTS Absolute numbers and percentages of CD3+ and CD4+ T cells were reduced in children with tuberculosis, compared to controls. CD4+ counts increased significantly following antituberculosis treatment, compared to baseline values. In contrast, the proportion of T cells expressing the gdT cell receptor was similar in tuberculosis patients and controls. CONCLUSION Children with tuberculosis have a systemic decrease in the proportion and number of CD3+ and CD4+ T cells which reverses during therapy.
Relationship between Budget Deficit and Current Account Balance in Kenya

As a rule of thumb, current account deficit should not exceed 5% of GDP. If it exceeds, it must raise concerns about its sustainability. In Kenya, current account balance deficit increased to 10.5% of the GDP by 2014 and 8.3% in 2015. Unsustainable current account deficits are a potential recipe for a currency crisis and current account reversal which have negative implications on macroeconomic stability of a country. The purpose of this study is to examine the effect of budget deficits on current account deficits in Kenya. The specific objectives were to establish relationship between budget deficits on current account deficits in Kenya, to find out the short term or a long run relationship among the variables and to identify direction of the causality. The study was guided Keynesian Theory and Ricardian theory. An explanatory research design was adopted. The study covered the period of 1970 to 2017. The study used data from secondary sources including WDI, KNBS and Economic Surveys. Descriptive statistics such as mean and standard deviation was used to perform data analysis. EVIEWS was used in the analysis. Autoregressive Distributed Lag model was used to estimate the best model. The speed of adjustment towards long run equilibrium was 44.6484% implying that the system will get back to long run equilibrium at the speed of 44.6484%. The study concluded that budget deficit have a significant long run effect on Current account deficit and also Current account deficit have a significant long run impact on Budget deficit. The study concluded that there exist a short run relationship between budget deficit and current account balance. For Kenya to progress the study advocates for favorable current account balance by reducing persistent deficits and achieving current account balance sustainability, several policy options should be applied. Deliberate export oriented approaches through product diversification and international trade promotion to ensure that our products can be competitive in the international markets. For Kenya to progress the study advocates for favorable current account balance by reducing persistent deficits and achieving current account balance sustainability, several policy options should be applied. Stability in exchange rate and low inflation are critical in ensuring productivity growth. Kew words: budget deficits, causality, current account deficits.
Functional analysis of the human IGF‐I gene promoters

The two putative promoter regions of the human insulin‐like growth factor‐I (IGF‐I) gene, located upstream of the two alternatively used leader exons 1 and 2, were tested for promoter activity in transient transfection assays. Both regions were shown to possess promoter activity. The results further indicate cell‐type‐specific regulation of the activities of the two promoters in endogenously IGF‐I producing human cell lines of different origin. © 1993 Wiley‐Liss, Inc.