Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics

Abstract Extensive efforts have been directed at the discovery, investigation and clinical monitoring of targeted therapeutics. These efforts may be facilitated by the convenient access of the genetic, proteomic, interactive and other aspects of the therapeutic targets. Here, we describe an update of the Therapeutic target database (TTD) previously featured in NAR. This update includes: (i) 2000 drug resistance mutations in 83 targets and 104 target/drug regulatory genes, which are resistant to 228 drugs targeting 63 diseases (49 targets of 61 drugs with patient prevalence data); (ii) differential expression profiles of 758 targets in the disease-relevant drug-targeted tissue of 12 615 patients of 70 diseases; (iii) expression profiles of 629 targets in the non-targeted tissues of 2565 healthy individuals; (iv) 1008 target combinations of 1764 drugs and the 1604 target combination of 664 multi-target drugs; (v) additional 48 successful, 398 clinical trial and 21 research targets, 473 approved, 812 clinical trial and 1120 experimental drugs, and (vi) ICD-10-CM and ICD-9-CM codes for additional 482 targets and 262 drugs against 98 disease conditions. This update makes TTD more useful for facilitating the patient focused research, discovery and clinical investigations of the targeted therapeutics. TTD is accessible at http://bidd.nus. edu.sg/group/ttd/ttd.asp.
Revisión sistemática: ligamento anterolateral de la rodilla

RESUMEN Introducción: numerosos estudios han sido realizados en los últimos años con el objetivo de mejorar el conocimiento del ligamento anterolateral (LAL) de la rodilla. Debido a esto, se cree conveniente realizar esta revisión bibliográfica para definir la incidencia, la anatomía, la biomecánica, la clínica, las pruebas de imagen y el tratamiento del mismo. Material y métodos: se realiza una búsqueda en las bases de datos PubMed/Medline/Cochrane. Se incluyeron estudios descriptivos tanto clínicos como in vitro sobre las consideraciones anatómicas, biomecánicas, clínicas, estudios de imagen, manejo quirúrgico y resultados del LAL de la rodilla hasta abril de 2017. Se excluyen artículos no escritos en inglés, publicados en revistas no indexadas, no realizados en humanos o cadáveres humanos y aquellos no pertenecientes a la rodilla. Resultados: el origen femoral es el que más discusión nos ofrece, insertándose en la tibia entre el tubérculo de Gerdy y la cabeza del peroné. Biomecánicamente, parece influir en la estabilidad rotacional, con escaso control de la estabilidad anteroposterior. Para su diagnóstico, disponemos del pivot shift en la exploración, fractura de Segond en la radiología simple, ecografía y resonancia magnética. ABSTRACT Systematic review: anterolateral ligament of the knee
Diagnostic utility of endobronchial ultrasound-guided transbronchial needle aspiration in elderly patients.

Introduction In the elderly population, diagnosis and initial treatment should be considered as soon as possible because of co-morbidities and complications. We aimed to evaluate the Þndings of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to determine the diagnostic utility of EBUS-TBNA in patients 65 years of age and older. Materials and Methods We retrospectively evaluated records of patients who underwent EBUS-TBNA from February 2014 to August 2017 for diagnosis and/or staging. The demographic data, clinical and EBUS Þndings, diagnostic procedures during EBUS-TBNA and the incidence of accurate diagnosis with EBUS-TBNA in patients 65 years of age and older and in younger patients were determined. Result A total of 496 patients [younger patients (< 65 years, n= 293, M/F: 198/95) and older patients (≥ 65 years, n= 203, M/F: 155/48)] who underwent EBUS-TBNA at our clinic were included. The mean age of the older patients was 69.7 ± 5.1 years, while the mean age of the younger patients was 51.4 ± 10.4 years. Overall, the diagnostic accuracy of EBUS-TBNA was 96.5% in the older patients and 98% in the younger patients. The diagnostic utility of EBUS-TBNA in the two study groups was similar (p= 0.191). While 196 (96.6%) of the older patients had no complications during EBUS-TBNA, 285 (97.3%) of the younger patients had no complications. Complication rates were not statistically different between the two groups (p= 0.389). Conclusions In general, EBUS-TBNA is a safe method. The results of this study demonstrated the high diagnostic value of EBUS-TBNA and its low complication rates in patients 65 years of age and older.
Therapeutical effects of vaccine from Trypanosoma cruzi amastigote surface protein 2 by simultaneous inoculation with live parasites

The aim of this study was to evaluate the efficacy of vaccine using replication‐deficient human recombinant Type 5 replication‐defective adenoviruses (AdHu5) carrying sequences of the amastigote surface protein 2 (ASP2) (AdASP2) in mice infected with the Trypanosoma cruzi ( T cruzi) Y strain. A total of 16 A/Sn mice female were distributed into four groups, as follows (n = 4 per group): Group 1 – Control Group (CTRL); Group 2 – Infected Group (TC): animals were infected by subcutaneous route with 150 bloodstream trypomastigotes of T cruzi Y strain; Group 3 – Immunized Group (AdASP‐2): animals were immunized by intramuscular injection (im) route with 50 µL of AdSP‐2 (2 × 10 8 plaque forming units [pfu]/cam) at day 0; Group 4‐Immunized and Infected Group (AdASP‐2+TC): animals were immunized by im route with 50 µL of ASP‐2 (2 × 10 8 pfu/cam) and infected by T cruzi at the same day (day 0). It was observed a significant decrease of nests in the group that was immunized with AdASP‐2 and infected on the same day. Tumor necrosis factor alpha (TNF‐α) and inducible nitric oxide synthase (iNOS) gene expressions showed a significant increase in the AdASP‐2+TC group when compared to TC group, but it was noted that Cyclooxygenase‐2 (Cox‐2) was increased in TC group when compared to AdASP‐2+TC group. Increase of matrix metalloproteinases‐2 (MMP‐2) and decrease of MMP‐9 immunoexpression in the AdASP‐2+TC group was noticed as well. Oxidative DNA damage was present in myocardium for AdASP‐2+TC group as a result of 8‐hydroxydeoxyguanosine immunoexpression. Taken together, our results highlighted an increased oxidative stress, MMP‐2 activity and inflammatory host response promoted by AdASP‐2 against T cruzi infection.
Climatic Controls on C4 Grassland Distributions During the Neogene: A Model-Data Comparison

Grasslands dominated by taxa using the C4 photosynthetic pathway evolved on several continents during the Neogene and Quaternary, long after C4 photosynthesis first evolved among grasses. The histories of these ecosystems are relatively well documented in the geological record from stable carbon isotopes (fossil vertebrate herbivores, paleosols) and the plant microfossil record (pollen, phytoliths). The distinct biogeography and ecophysiology of modern C3 and C4 grasses have led to hypotheses explaining the origins of C4 grasslands in terms of long term changes in the Earth system, such as increased aridity and decreasing atmospheric pCO2. However, proxies for key parameters of these hypotheses (e.g., temperature, precipitation, pCO2) are still in development, not yet widely applied, and/or remain contentious, so testing the hypotheses globally remains difficult. To understand better possible links between changes in the Earth system and the origin of C4 grasslands, we undertook a global scale comparison between observational records of C4 grass abundances in Miocene and Pliocene localities compiled from the literature and three increasingly complex models of C4 dominance and abundance. The literature compilation comprises >2,600 δ13C values of both fossil vertebrates and of paleosol carbonates. We forced the vegetation models with simulated monthly climates from the HadCM3 family of coupled ocean-atmosphere GCMs over a range of pCO2 values for each epoch to model C4 dominance or abundance in grid cells as months per year exceeding the temperature at which net carbon assimilation is greater for C4 than C3 photosynthesis (crossover temperature model); the number of months per year exceeding the crossover temperature and having sufficient precipitation for growth (≥25 cm/yr; Collatz model); and the Sheffield Dynamic Global Vegetation Model (SDGVM), which models multiple plant functional types (C3 and C4 grasses, evergreen and deciduous trees). Model-data agreement is generally statistically weak, suggesting that regional to local ecological interactions, continent specific plant evolutionary histories, and/or regional to local climatic conditions not represented in global scale GCMs may have been equally as strong or stronger in driving the evolution of C4 grasslands as global changes in the Earth system.
Multiple stages of tree seedling recruitment are altered in tropical forests degraded by selective logging

Abstract Tropical forest degradation is a global environmental issue. In degraded forests, seedling recruitment of canopy trees is vital for forest regeneration and recovery. We investigated how selective logging, a pervasive driver of tropical forest degradation, impacts canopy tree seedling recruitment, focusing on an endemic dipterocarp Dryobalanops lanceolata in Sabah, Borneo. During a mast‐fruiting event in intensively logged and nearby unlogged forest, we examined four stages of the seedling recruitment process: seed production, seed predation, and negative density‐dependent germination and seedling survival. Our results suggest that each stage of the seedling recruitment process is altered in logged forest. The seed crop of D. lanceolata trees in logged forest was one‐third smaller than that produced by trees in unlogged forest. The functional role of vertebrates in seed predation increased in logged forest while that of non‐vertebrates declined. Seeds in logged forest were less likely to germinate than those in unlogged forest. Germination increased with local‐scale conspecific seed density in unlogged forest, but seedling survival tended to decline. However, both germination and seedling survival increased with local‐scale conspecific seed density in logged forest. Notably, seed crop size, germination, and seedling survival tended to increase for larger trees in both unlogged and logged forests, suggesting that sustainable timber extraction and silvicultural practices designed to minimize damage to the residual stand are important to prevent seedling recruitment failure. Overall, these impacts sustained by several aspects of seedling recruitment in a mast‐fruiting year suggest that intensive selective logging may affect long‐term population dynamics of D. lanceolata. It is necessary to establish if other dipterocarp species, many of which are threatened by the timber trade, are similarly affected in tropical forests degraded by intensive selective logging.
Lake regionalization and diatom metacommunity structuring in tropical South America

Abstract Lakes and their topological distribution across Earth's surface impose ecological and evolutionary constraints on aquatic metacommunities. In this study, we group similar lake ecosystems as metacommunity units influencing diatom community structure. We assembled a database of 195 lakes from the tropical Andes and adjacent lowlands (8°N–30°S and 58–79°W) with associated environmental predictors to examine diatom metacommunity patterns at two different levels: taxon and functional (deconstructed species matrix by ecological guilds). We also derived spatial variables that inherently assessed the relative role of dispersal. Using complementary multivariate statistical techniques (principal component analysis, cluster analysis, nonmetric multidimensional scaling, Procrustes, variance partitioning), we examined diatom–environment relationships among different lake habitats (sediment surface, periphyton, and plankton) and partitioned community variation to evaluate the influence of niche‐ and dispersal‐based assembly processes in diatom metacommunity structure across lake clusters. The results showed a significant association between geographic clusters of lakes based on gradients of climate and landscape configuration and diatom assemblages. Six lake clusters distributed along a latitudinal gradient were identified as functional metacommunity units for diatom communities. Variance partitioning revealed that dispersal mechanisms were a major contributor to diatom metacommunity structure, but in a highly context‐dependent fashion across lake clusters. In the Andean Altiplano and adjacent lowlands of Bolivia, diatom metacommunities are niche assembled but constrained by either dispersal limitation or mass effects, resulting from area, environmental heterogeneity, and ecological guild relationships. Topographic heterogeneity played an important role in structuring planktic diatom metacommunities. We emphasize the value of a guild‐based metacommunity model linked to dispersal for elucidating mechanisms underlying latitudinal gradients in distribution. Our findings reveal the importance of shifts in ecological drivers across climatic and physiographically distinct lake clusters, providing a basis for comparison of broad‐scale community gradients in lake‐rich regions elsewhere. This may help guide future research to explore evolutionary constraints on the rich Neotropical benthic diatom species pool.
Óleo de soja e gordura animal na alimentação de eqüinos.

O objetivo deste trabalho foi estudar os efeitos da gordura animal e do oleo de soja como fontes de energia em potras da raca Arabe e Cruza/Arabe. Forarm utilizados 21 animais, com peso medio inicial de 228 kg e 13 meses de idade media, distribuidos em tres tratamentos.
Logically-Constrained Neural Fitted Q-Iteration

We propose a method for efficient training of Q-functions for continuous-state Markov Decision Processes (MDPs) such that the traces of the resulting policies satisfy a given Linear Temporal Logic (LTL) property. LTL, a modal logic, can express a wide range of time-dependent logical properties (including "safety") that are quite similar to patterns in natural language. We convert the LTL property into a limit deterministic Buchi automaton and construct an on-the-fly synchronised product MDP. The control policy is then synthesised by defining an adaptive reward function and by applying a modified neural fitted Q-iteration algorithm to the synchronised structure, assuming that no prior knowledge is available from the original MDP. The proposed method is evaluated in a numerical study to test the quality of the generated control policy and is compared with conventional methods for policy synthesis such as MDP abstraction (Voronoi quantizer) and approximate dynamic programming (fitted value iteration).
Prior Exposure Increases Perceived Accuracy of Fake News

The 2016 U.S. presidential election brought considerable attention to the phenomenon of “fake news”: entirely fabricated and often partisan content that is presented as factual. Here we demonstrate one mechanism that contributes to the believability of fake news: fluency via prior exposure. Using actual fake-news headlines presented as they were seen on Facebook, we show that even a single exposure increases subsequent perceptions of accuracy, both within the same session and after a week. Moreover, this “illusory truth effect” for fake-news headlines occurs despite a low level of overall believability and even when the stories are labeled as contested by fact checkers or are inconsistent with the reader’s political ideology. These results suggest that social media platforms help to incubate belief in blatantly false news stories and that tagging such stories as disputed is not an effective solution to this problem. It is interesting, however, that we also found that prior exposure does not impact entirely implausible statements (e.g., “The earth is a perfect square”). These observations indicate that although extreme implausibility is a boundary condition of the illusory truth effect, only a small degree of potential plausibility is sufficient for repetition to increase perceived accuracy. As a consequence, the scope and impact of repetition on beliefs is greater than has been previously assumed.
A new methodology to evaluate the flying shape of a sail

In the last years, many improvements have been made in sailing yacht design with particular regard to shapes, materials and building technologies. As racing yacht competitiveness is more and more growing, there is an increasing need for improvements of the sails and the hulls performances. In this context, the Computational Fluid Dynamics (CFD) method is increasingly used in the design process of the sails. Numerical simulations, nevertheless, are usually performed only on the design shape of the sail, without considering that the real flying shape of a sail greatly varies when subject to the normal working conditions. For these reasons, often, the real performances of a sail are very different from the ones estimated during the design phase. To overcome this problem, in the presented paper, an innovative methodology has been developed to evaluate the real (flying) shape of a sail during the design process. In particular, an iterative procedure has been setup to analyse, by means of a coupled CFD/FEM analysis, the fluid-structure interaction in a simplified model of a sail. The method allows to predict the real flying shape of a sail and, consequently, to optimize its performances.
The Neuromodulation Appropriateness Consensus Committee on Best Practices for Dorsal Root Ganglion Stimulation

The Neuromodulation Appropriateness Consensus Committee (NACC) is dedicated to improving the safety and efficacy of neuromodulation and thus improving the lives of patients undergoing neuromodulation therapies. With continued innovations in neuromodulation comes the need for evolving reviews of best practices. Dorsal root ganglion (DRG) stimulation has significantly improved the treatment of complex regional pain syndrome (CRPS), among other conditions. Through funding and organizational leadership by the International Neuromodulation Society (INS), the NACC reconvened to develop the best practices consensus document for the selection, implantation and use of DRG stimulation for the treatment of chronic pain syndromes.
Paraphrase Detection on Noisy Subtitles in Six Languages

We perform automatic paraphrase detection on subtitle data from the Opusparcus corpus comprising six European languages: German, English, Finnish, French, Russian, and Swedish. We train two types of supervised sentence embedding models: a word-averaging (WA) model and a gated recurrent averaging network (GRAN) model. We find out that GRAN outperforms WA and is more robust to noisy training data. Better results are obtained with more and noisier data than less and cleaner data. Additionally, we experiment on other datasets, without reaching the same level of performance, because of domain mismatch between training and test data.
A systematic review of injuries in gymnastics

ABSTRACT Objectives: To identify all studies of gymnastics injuries and assess injury rates, types, locations, and causes. Methods: Seven electronic and two grey literature databases were searched. Two reviewers independently assessed titles/abstracts, abstracted data, and calculated average rates weighted by study size. Results: One study (n = 963) of three Olympic games (2008,2012,2016) provided injury rates for females of 86.4/1000gymnasts and males 79.9. For 29 databases one study of males (n = 64) provided a rate of 8.8 injuries/1000hours/AE (AE = athletic-exposure) and three of females varied rates (8.5, 9.4, and 91). Three studies for males (n = 153) provided a weighted average rate of 1.4 injuries/1000hours/training, and for females six studies (n = 476) 1.5 injuries. Four studies of males (n = 286) provided a weighted average of 678 injuries/1000gymnasts per year and eight studies of females (n = 1,764) a rate of 306. Of 19 surveys, eight provided rates for females (n = 1,463) of 596 injuries/gymnast per year and two for males (n = 40) a rate of 1,036. In the Olympics injuries were preponderately lower limb (63%) then trunk (23%) and upper limb (14%); injury type was sprains (35%) followed by tendinopathy/arthritis/impingements (17%), contusions (10%), and fractures (7%). Five database studies provided injury location data for 274 males: averages weighted by study size were upper extremity 42.8%, lower extremity 33.6%, torso/spine 11.8%, and head/neck 4.9% and 12 studies with 843 females provided average rates for lower extremity 51%, upper extremity 30.8%, torso/spine 13% and head/neck 0.8%. Official gymnastics organizations’ websites provide no readily available data about injury rates or methods of prevention. Conclusions: Studies need to collect comprehensive data for injury rates by training/competitions, gender, age, injury location/type/cause. Studies could assess whether trainers and physiotherapists monitoring gymnasts closely for injury risk would reduce injuries. Studies including randomized controlled trials (RCTs) of interventions in training, videotaping and performance feedback to reduce injury rates would be helpful.
Discriminating chronic pancreatitis from pancreatic cancer: Contrast-enhanced EUS and multidetector computed tomography in direct comparison

Background and Objectives: To compare the ability of multidetector computed tomography (MDCT) and contrast-enhanced EUS to discriminate chronic pancreatitis (CP) from pancreatic ductal adenocarcinoma (PDAC). Subjects and Methods: A total of 215 patients (age: 62 ± 15 years, sex: f/m 80/135) were included in this retrospective study. All patients were examined by conventional endoscopic B-mode and contrast-enhanced high mechanical index EUS (CEHMI-EUS). CELMI-EUS was performed in 159 patients and endoscopic sonoelastography (ESE) in 210 patients. MDCT was carried out in 131 patients as part of their clinical work-up. Radiological reports were retrospectively analyzed. Final diagnosis was achieved by biopsy and evaluation of cytological specimens collected was performed by EUS-FNA, surgery, or follow-up of 12 months or more in patients with benign findings. In a subgroup of 100 patients, all diagnostic five methods were performed, and head-to-head analysis was performed. Results: Sensitivity and specificity for MDCT were 89% and 70% and for CEHMI-EUS were 96% and 91%, respectively. Sensitivities and specificities for EUS were 92% and 63% for B-Mode EUS, 96% and 38% for ESE, and 82% and 76% for CELMI-EUS, respectively. In the head-to-head analysis, each modality had shown lower numbers for specificity than shown in the overall group analysis because of high drop-out rate. EUS-FNA for PDAC had a sensitivity of 96% and a specificity of 100%. Conclusions: Contrast-enhanced EUS is a reliable tool in discriminating PDAC from CP.