Miracle-dz/UniFAR-FTUs huggingface dataset:
Extended kinematic path control of robot arms

SUMMARY Path planning a robot arm motion essentially requires that the constraints of the joint variables and the vector of the joint motion rates are taken into account. In order to satisfy the constraints of the joint variables a sliding mode is being employed together with the developed kinematic path control method. The extended form of the kinematic path control method, here proposed, treats simultaneously the constraints of the joint variables and the vector of joint motion rates in path planning a robot arm motion.
IRM multimodale sériée dans les gliomes infiltrants du tronc cérébral chez l'enfant

Le gliome infiltrant du tronc cerebral est une tumeur gliale pediatrique de tres mauvais pronostic. La survie mediane des patients varie entre 9 et 12 mois. Son aspect typique en imagerie permet le diagnostic sans confirmation histologique mais a limite la comprehension de la physiopathologie de ces tumeurs pendant plusieurs annees. L'identification des mutations des histones H3 K27M comme identite moleculaire des gliomes infiltrants du tronc cerebral definit cette tumeur comme une entite unique en 2012 et la separe des autres tumeurs cerebrales. Il y a deux variantes des histones H3 a l’origine des tumeurs, la variante H.3. 1 et la variante H3.3 qui forment deux sous-groupes presentant des phenotypes et des pronostics differents. L'objectif de cette these etait d'utiliser les techniques d'imagerie multimodale pour mieux comprendre la physiopathologie des gliomes infiltrants du tronc cerebral, en observant l'evolution des effets des differents traitements a differents temps. Nous avons tout d'abord montre une augmentation des index de perfusion associee a une diminution de l'oedeme lesionnel en post- radiotherapie. Puis nous avons decrit en imagerie le phenomene de pseudo-progression. Ce phenomene, qu’il ne faut pas prendre pour une vraie progression tumorale, est caracterise par une augmentation du volume et du rehaussement tumoral associe a une augmentation importante des index de perfusion. Le ratio d’augmentation du flux sanguin lesionnel dans les suites de la radiotherapie permet identifier une pseudo-progression avec une sensibilite et une specificite elevees. Ces 2 groupes de patients (sans et avec pseudo-progression) ont un comportement en imagerie tres differents en fin de vie. Nous avons ensuite compare les parametres d'imagerie aux donnees histologiques pour mieux apprehender les deux types de mutation d'histones. Les tumeurs H3.1 presentent plus d'oedeme, plus de necrose et une perfusion moins elevee. Les tumeurs H3.3 ont une perfusion plus elevee et moins d'oedeme. La valeur du volume sanguin lesionnel est positivement correlee a la charge tumorale. L’imagerie multimodale est essentielle dans le suivi et la comprehension des mecanismes physiopathologiques des DIPG. Elle devra etre incluse dans les protocoles de recherches (efficacite des nouvelles chimiotherapies ciblees et nouvelles techniques d’application, modeles murins, radiomics, correlation avec les nouvelles quantifications histologiques) dans le but d’avancer puis un jour de guerir ces petits patients.
The 7 th International Conference on Ambient Systems , Networks and Technologies ( ANT 2016 ) DENCLUE-IM : A New Approach for Big Data Clustering

Every day, a large volume of data is generated by multiple sources, social networks, mobile devices, etc. This variety of data sources produce an heterogeneous data, which are engendered in high frequency. One of the techniques allowing to a better use and exploit this kind of complex data is clustering. Finding a compromise between performance and speed response time present a major challenge to classify this monstrous data. For this purpose, we propose an efficient algorithm which is an improved version of DENCLUE, called DENCLUE-IM. The idea behind is to speed calculation by avoiding the crucial step in DENCLUE which is the Hill Climbing step. Experimental results using large datasets proves the efficiency of our proposed algorithm. c © 2016 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the Conference Program Chairs.
Accelerated Telomere Shortening and Telomere Abnormalities in Radiosensitive Cell Lines

Abstract Cabuy, E. , Newton, C. , Joksic, G. , Woodbine, L. , Koller, B. , Jeggo, P. A. and Slijepcevic, P. Accelerated Telomere Shortening and Telomere Abnormalities in Radiosensitive Cell Lines. Radiat. Res. 164, 53–62 (2005). We examined telomere maintenance in cells of 11 primary fibroblast cell lines with differing genetic defects that confer sensitivity to ionizing radiation. These included cell lines derived from patients with ataxia telangiectasia, Nijmegen breakage syndrome, Fanconi anemia, defective Artemis, DNA ligase I and DNA ligase IV, an immunodeficient patient with a defect in DNA double-strand break repair, and a patient diagnosed with xeroderma pigmentosum who, in addition, showed severe clinical sensitivity to ionizing radiation. Our results, based on Southern blot, flow-FISH and Q-FISH (quantitative FISH) measurements, revealed an accelerated rate of telomere shortening in most cell lines derived from the above patients compared to cell lines from normal individuals or a cell line isolated from a heterozygotic parent of one radiosensitive patient. This accelerated telomere shortening was accompanied by the formation of chromatin bridges in anaphase cells, indicative of the early loss of telomere capping function and in some cases low levels of chromosome abnormalities in metaphase cells. We also analyzed telomere maintenance in mouse embryonic stem cells deficient in Brca1, another defect that confers radiosensitivity. Similarly, these cells showed accelerated telomere shortening and mild telomere dysfunction in comparison to control cells. Our results suggest that mechanisms that confer sensitivity to ionizing radiation may be linked with mechanisms that cause telomere dysfunction.
β‐Cell mass plasticity in type 2 diabetes

Prospective studies have shown that insulin resistance (IR) and impaired insulin secretion are independent predecessors and predictors of overt diabetes in genetically predisposed individuals [1–3]. Studies involving subjects at high risk of progression to type 2 diabetes (T2D) have shown that b-cell function begins to decline prior to presentation of elevated, fasting plasma glucose levels, thus predicting the subsequent development of T2D [4]. With the onset of IR, rates of both insulin biosynthesis and secretion are amplified, coupled with increases in b-cell mass and hypertrophy of existing b-cells to meet the increase in demand [5]. As the b-cell mass reaches its threshold to compensate, the burden of IR can no longer be overcome [6]. In those individuals with a genetic predisposition, this lack of pancreatic plasticity ultimately leads to hyperglycaemia [7]. After years of controversy regarding the primacy of either a b-cell defect or IR in the pathogenesis of T2D, we now recognize that various degrees of both alterations must coexist for hyperglycaemia to become manifest. While much is known about the mechanisms of IR, the causes for b-cell defects remain poorly understood. Still more enigmatic is the clinical relationship of the functional b-cell defect to actual b-cell mass. Vague terms such as b-cell exhaustion and fatigue, b-cell rest and survival and b-cell preservation provide little direction towards the effective therapeutic strategies for preserving b-cell function and mass. As the incidence of T2D continues to increase at an alarming rate, it is becoming imperative that the clinical focus shift towards the preservation of b-cell function and mass. Widespread efforts are being undertaken in an attempt to understand the mechanisms that regulate b-cell mass and to determine precisely what goes awry in T2D. Clinicians, however, are limited by the fact that there is no method for monitoring b-cell mass. In the following review, we discuss factors that influence b-cell mass and potential strategies for therapeutic intervention in the preservation of b-cell mass.
Comparing User QoE via Physiological and Interaction Measurements of Immersive AR and VR Speech and Language Therapy Applications

Virtual reality (VR) and augmented reality (AR) applications are gaining significant attention in industry and academia as potential avenues to support truly immersive and interactive multimedia experiences. Understanding the user perceived quality of immersive multimedia experiences is critical to the success of these technologies. However, this is a multidimensional and multifactorial problem. The user quality of experience (QoE) is influenced by human, context and system factors. Attempts to understand QoE via multimedia quality assessment has typically involved users reporting their experiences via post-test questionnaires. More recently, efforts have been made to automatically collect objective metrics that can quantitatively reflect user QoE in terms of physiological measurement methods. In this context, this paper presents a novel comparison of objective quality measures of immersive AR and VR applications through physiological: (electrodermal activity (EDA) and heart rate (HR)); and interaction (response times (RT), incorrect responses, and miss-click) metrics. The analysis shows consistency in terms of physiological ratings and miss-click metrics between the AR and VR groups. Interestingly, the AR group reported lower response times and less incorrect responses compared to the VR group. The difference between the AR and VR groups was statistically significant for the incorrect response metric and in 45.5% of the cases tested for response times metric, they were statistically significant with 95% confidence levels.
Expression and location of Smad2, 4 mRNAs during and after liver fibrogenesis of rats.

AIM To investigate the location alteration of Smad2 and Smad4 mRNAs in the liver during and after fibrogenesis in rats. METHODS Eighty male Wistar rats weighing approximately 200 g each were used. The rat models of experimental hepatic fibrosis were established by injection with carbon tetrachloride (CCl4), normal rats and rats were injected with olive oil and served as control groups. In situ hybridization(ISH) was used to detect the Smad2 and Smad4 mRNA in liver. RESULTS In situ hybridization showed Smad2 and Smad4 mRNA expressions in the cytoplasm of hepatic stellate cells (HSC), fibroblasts and myofibroblasts around the central vein and hepatic sinus during and after fibrogenesis. Expression of Smad2, 4 mRNA was higher than that in normal and control rats. CONCLUSION In the process of and after hepatic fibrosis formation, HSC, fibroblasts and myofibroblasts are the major cells that express Smad2 and Smad4. The more serious the hepatic fibrosis is in the injured liver, the higher the level of Smad2 and Smad4 gene expression is during and after fibrogenesis respectively.
Proteomic profiling during the pre-competent to competent transition of the biofouling polychaete Hydroides elegans

The polychaete, Hydroides elegans, is a tube-building worm that is widely distributed in tropical and subtropical seas. It is a dominant fouling species and thus a major target organism in antifouling research. Here, the first high-throughput proteomic profiling of pre-competent and competent larvae of H. elegans is reported with the identification of 1,519 and 1,322 proteins, respectively. These proteins were associated with a variety of biological processes. However, a large proportion was involved in energy metabolism, redox homeostasis, and microtubule-based processes. A comparative analysis revealed 21 proteins that were differentially regulated in larvae approaching competency.
AUC / MIC RATIO AS A TOOL IN DETERMINING EFFECTIVENESS OF GARASENT ® FOR THE PREVENTION OF EARLY ONSET SEPSIS IN HOSPITALIZED NEONATES

Objectives: To evaluate AUC/MIC ratio as a tool in determining effectiveness of Garasent® (gentamicin) as a combination therapy for suspected early onset sepsis (EOS). Methods: This is a cross-sectional study on neonates in Hospital Raja Permaisuri Bainun Ipoh, Malaysia. The study reviewed records of neonatal patients cases admitted within their 72 hours of life and prescribed with gentamicin combination therapy for suspected EOS. Ratio of area under the curve (AUC) to minimum inhibitory concentration (MIC) of Klebsiella pneumoniae and Coagulase-negative staphylococci (CoNS) was used to determine effectiveness between AUC groups. MIC for both organisms was set at 1mg/L. Results/Discussion: Hundred and twenty cases met the inclusion criteria and pharmacokinetics parameters of gentamicin were calculated. Gentamicin was combined with C-penicillin (n=119) or ampicillin (n=1) with mean dose of 4mg/kg q 24-48h and majority was started within 24h of life. Cases were divided into two different AUC group, group 1 <100mg/L/h (n=54) and group 2 >100 mg/L/h (n=66). Ratio of average AUC/MIC was 72 and 135 in group 1 and group 2 respectively. There was no significant difference in term of gender and race between groups (p>0.05). Group 1 has higher mean of birth weight and gestational age and shorter length of stay but it was statistically insignificant. Both groups show 100% treatment successful rate with median treatment duration of 3 days. However, group 2 showed higher numbers of above normal trough (>1μg/ml) and peak (>10μg/ml) concentrations associated with increased risk of toxicity. Conclusions: AUC/MIC ratio is not a determinant to associate Garasent® effectiveness in the prevention EOS. However, higher AUC/MIC ratio can potentially increase the risk of toxicity.
La ilusión de la mano de goma: factores implicados, bases neurales y aplicaciones clínicas The rubber hand illusion: involved factors, neural basis and clinical applications

Resumen La “Ilusion de la Mano de Goma” es un procedimiento que permite inducir a un sujeto sano la sensacion de que una mano falsa es su propia mano. Pequenas modificaciones en el metodo original puede alterar o incluso abolir la ilusion. Asimismo se han detectado varios factores individuales que influyen en la intensidad de la vivencia subjetiva de la ilusion, ademas de ciertos rasgos psicopatologicos sensibles a la aparicion de la misma. Como cualquier fenomeno cognitivo, la ilusion de la mano de goma tiene un sustrato neural, y aunque sigue siendo incierto, las recientes investigaciones han detectado ciertas correlaciones entre distintas areas cerebrales y la aparicion de la ilusion. La conciencia corporal es fundamental para una correcta interaccion con el entorno circundante, por lo que su perturbacion puede causar una autentica psicopatologia. Los avances en el paradigma de la ilusion de la mano de goma estan permitiendo conocer los distintos ambitos donde este procedimiento puede resultar un buen instrumento para la deteccion y el tratamiento de distintas patologias.
Short term forecasting with support vector machines and application to stock price prediction

Forecasting a stock price movement is one of the most difficult problems in finance. The reason is that financial time series are complex, non stationary. Furthermore, it is also very difficult to predict this movement with parametric models. Instead of parametric models, we propose two techniques, which are data driven and non parametric. Based on the idea that excess returns would be possible with publicly available information, we developed two models in order to forecast the short term price movements by using technical indicators. Our assumption is that the future value of a stock price depends on the financial indicators although there is no parametric model to explain this relationship. This relationship comes from the technical analysis. Comparison shows that support vector regression (SVR) out performs the multi layer perceptron (MLP) networks for a short term prediction in terms of the mean square error. If the risk premium is used as a comparison criterion, then the SVR technique is as good as the MLP method or better.
I-Cell Disease: Biochemical Studies

Extract: Six patients with I-cell disease (ICD) are studied. Multiple acid hydrolase deficiencies are demonstrated in cultured skin fibroblasts. These include βs-galactosidase (2% of normal), β-glucosaminidase (8% of normal), β-glucuronidase (7% of normal), α-ga-lactosidase (10% of normal), and arylsulfatase A (5% of normal). Acid hydrolases found not to be deficient include β-glucosidase and acid phosphatase.In brain and visceral organs, only β-galactosidase is deficient (27% of normal in brain; 11% of normal in liver). A nonspecific accumulation of lipids of all classes occurs in skin fibroblasts (2–3 times normal), but not in brain or visceral organs.No accumulation of acid mucopolysaccharides is demonstrated in skin fibroblasts or liver.Speculation: I-cell disease may represent a unique opportunity for the study of control of intracellular levels of lysosomal enzymes.
Low-cost monitoring system for solar farm using agent technology

Currently one of the main sources of renewable energy is solar energy, which is presented as an alternative energy for sustainable development in protecting the planet. Solar farms are large areas of land where large amount of solar panels are connected together. Adding intelligence to control systems in solar farms allows monitoring and managing tasks, therefore is possible to detect malfunctions in the equipment and solves it. This paper presents a multi-agent monitoring system for a solar farm, that allows controlling the main indicators of solar panels such as power, current, voltage and position, with the aim of early fault detection in the panels and bring out actions for better performance.
The synergistic effects of the IL‐9 gene and environmental exposures on asthmatic Taiwanese families as determined by the transmission/disequilibrium test

Asthma occurs in genetically susceptible individuals in the presence of environmental factors. The interleukin‐9 (IL‐9) gene, one of the cytokine genes located on chromosome 5q31, plays an important role in the development of asthmatic syndrome by enhancing both T‐cell and mast‐cell function. This study investigated GT repeat polymorphism of the IL‐9 gene and the gene–environment interactions, which may predispose individuals to asthma and atopy pathogenesis. In this study, we used the transmission/disequilibrium test (TDT) to investigate the relationship between asthma and the IL‐9 gene by studying 123 parent–offspring trios and 91 siblings. For allele‐specific TDT chi‐squared test, allele 122 of the IL‐9 gene showed significant association with asthmatics with specific IgE against house dust (HD) (P = 0.038). The additions of covariates to TDT to conduct the synergistic effects between the IL‐9 gene and environmental factors into account were estimated by conditional logistic regression models. The odds ratio for transmission of allele 122 of the IL‐9 gene was 1.23 (P = 0.28) for all asthmatic probands. There was slight increased interaction effect on asthma between transmission of allele 122 of IL‐9 gene to offspring and who were exposed to the fur of pets (OR = 3.33, P = 0.047). We also detected elevated odds of transmission of allele 122 to atopic asthmatic probands (OR = 2.08, P = 0.03) and offspring with very high levels of serum IgE (≥ 800 IU mL−1). In conclusion, this study has found that the IL‐9 gene was slightly associated with asthmatics who have positive specific IgE against Der p (or Der f) and house dust, when information on environmental factors was incorporated as effect modifiers.
Apport de la médecine manuelle ostéopathique dans la prise en charge des pathologies ostéo-articulaires en médecine générale

Les maladies osteo-articulaires sont un motif frequent de consultation en medecine generale. Les medecins generalistes et internes expriment une difficulte de prise en charge concernant ces pathologies. Par ailleurs, on note une surconsommation de soins osteopathiques par la population. Nous nous interrogeons donc sur l’apport d’une formation generale en Medecine Manuelle Osteopathique, et plus specifiquement de son approche clinique osteo-articulaire dans le cursus universitaire. Au cours de l’annee 2016-2017, dix entretiens ont ete effectues aupres de medecins generalistes disposant de cette formation sur les departements du Finistere et du Morbihan. Acquerir cette formation osteo-articulaire, selon eux complementaire, a ete un apport diagnostique et therapeutique dans leur accompagnement global, en lien avec l’etude de l’examen physique, le developpement du toucher relationnel et therapeutique, et la proposition d’une alternative de prise en charge manuelle. Ils notent par ailleurs un impact en termes de sante publique par une diminution des examens radiologiques, des prescriptions medicamenteuses, ainsi qu’un epanouissement personnel et professionnel. Proposer une formation complementaire en Medecine Manuelle Osteopathique au cours du cursus universitaire ou de la Formation Medicale Continue, semble interessante pour apprehender la prise en charge osteo-articulaire en medecine generale.
Development of physical fitness in children with intellectual disabilities.

BACKGROUND Few studies examined the development of physical fitness in children and youth with intellectual disabilities (ID), but the developmental patterns of physical fitness are largely unknown. The first aim was to examine physical fitness of primary school children with ID, aged 8-12, and compare the results with typically developing children in order to determine the performance level of children with ID. The second aim was to investigate the developmental trajectory of physical fitness in children with ID and the possible influence of gender and severity of cognitive impairment in a 4-year during longitudinal study. METHOD Seventy-three children with borderline or mild ID (51 boys, 22 girls; age range 8-11 in the year of enrolment) were measured annually on running speed, aerobic endurance (cardiovascular endurance), explosive strength, handgrip strength and trunk strength. Physical fitness scores of 515 typically developing children (266 boys, 249 girls; age range 8-12) were collected for reference values. RESULTS The results indicated statistically significant differences (with moderate to large Effect Sizes) between children with ID and typically developing children in all ages, favouring the typically developing children, and showed that the gap remained stable across the ages or decreased with increasing age. Multilevel models showed that the children with ID developed statistically significant on all items of physical fitness between age 8 and age 12. There was no statistically significant effect of gender on physical fitness, and the developmental trajectories were similar for boys and girls. For children with borderline and mild ID the developmental trajectories were parallel, but children with mild ID scored statistically significant worse on running speed, explosive strength and handgrip strength. CONCLUSIONS Despite statistically significant development of physical fitness in children with ID, their physical fitness levels should be stimulated. This should start already in young children (<8 years) and the children with the most severe cognitive impairments need special attention.