Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation of Protein Function and Signaling by Reversible Cysteine S-Nitrosylation*

NO is a versatile free radical that mediates numerous biological functions within every major organ system. A molecular pathway by which NO accomplishes functional diversity is the selective modification of protein cysteine residues to form S-nitrosocysteine. This post-translational modification, S-nitrosylation, impacts protein function, stability, and location. Despite considerable advances with individual proteins, the in vivo biological chemistry, the structural elements that govern the selective S-nitrosylation of cysteine residues, and the potential overlap with other redox modifications are unknown. In this minireview, we explore the functional features of S-nitrosylation at the proteome level and the structural diversity of endogenously modified residues, and we discuss the potential overlap and complementation that may exist with other cysteine modifications.
Managing broader product lines through delayed differentiation using vanilla boxes

In an attempt to reduce cost while maintaining good customer service, some of the leading manufacturers in the computer industry are delaying product differentiation (by exploiting component commonality) while managing broader product lines. In an environment wheredemands are stochastic, it seems a good strategy to store inventory in the form of semi-finished products (vanilla boxes) that can serve more than one final product. However, finding the optimal configurations and inventory levels of the vanilla boxes could be a challenging task. In this paper, we model the above problem as a two-stage integer program with recourse. By utilizing structural decomposition of the problem and (sub)gradient derivative methods, we provide an effective solution procedure. A special case, a variant, and several extensions are also discussed. In our computational section, we utilize our model to study several new research issues. We provide insights on the effect of demand variance, correlation, and capacity limitations on the optimal configuration and inventory levels of vanilla boxes and the performance of a vanilla assembly process. In addition, we compare the performance of the vanilla assemblyprocess to make-to-stock and assemble-to-order processes and provide managerial insights onthe conditions under which one might be better than the others. Finally, we discuss the characteristicsof an IBM product line (which motivated this work) and the effectiveness of a heuristictailored for that application.
New Technology: Femtosecond Laser May be Used for Future Acupuncture Therapy

Acupuncture therapy is utilized to cure many diseases and to maintain health. We have been studying the molecular mechanism of acupuncture and obtained its molecular evi‐ dence [1-4]. The World Health Organization has listed more than 40 indications for acu‐ puncture [5], and the National Institutes of Health (NIH) has accepted the validity of acupuncture treatment [6,7]. One of the popular uses of acupuncture treatment is to treat muscle exhaustion, including stiff shoulders. Major acupuncture techniques involve pene‐ tration of the skin by thin, solid metallic needles, which are manipulated manually or are stimulated electrically. The efficacy of such muscle therapy is attributed to the over‐ proliferation of muscle cells induced by the damage of muscle in response to the needle penetration. We recently reported that myostatin gene expression is suppressed by elec‐ troacupuncture (EA) [1].
Liver fibrosis: The hepatocyte revisited

Activated fibroblasts are key contributors to the fibrotic extracellular matrix accumulation during liver fibrosis. The origin of such fibroblasts is still debated, although several studies point to stellate cells as the principal source. The role of adult hepatocytes as contributors to the accumulation of fibroblasts in the fibrotic liver is yet undetermined. Here, we provide evidence that the pro-fibrotic growth factor, TGF1, induces adult mouse hepatocytes to undergo phenotypic and functional changes typical of epithelial to mesenchymal transition (EMT). We perform lineage-tracing experiments using AlbCre.R26RstoplacZ double transgenic mice to demonstrate that hepatocytes that undergo EMT contribute substantially to the population of FSP1-positive fibroblasts in CCl4induced liver fibrosis. Furthermore, we demonstrate that bone morphogenic protein-7 (BMP7), a member of the TGF superfamily, which is known to antagonize TGF signaling, significantly inhibits progression of liver fibrosis in these mice. BMP7 treatment abolishes EMT-derived fibroblasts, suggesting that the therapeutic effect of BMP7 was at least partially due to the inhibition of EMT. These results provide direct evidence for the functional involvement of adult hepatocytes in the accumulation of activated fibroblasts in the fibrotic liver. Furthermore, our findings suggest that EMT is a promising therapeutic target for the attenuation of liver fibrosis.
PREDIRCAM eHealth Platform for Individualized Telemedical Assistance for Lifestyle Modification in the Treatment of Obesity, Diabetes, and Cardiometabolic Risk Prevention: A Pilot Study (PREDIRCAM 1 >

Background: Healthy diet and regular physical activity are powerful tools in reducing diabetes and cardiometabolic risk. Various international scientific and health organizations have advocated the use of new technologies to solve these problems. The PREDIRCAM project explores the contribution that a technological system could offer for the continuous monitoring of lifestyle habits and individualized treatment of obesity as well as cardiometabolic risk prevention. Methods: PREDIRCAM is a technological platform for patients and professionals designed to improve the effectiveness of lifestyle behavior modifications through the intensive use of the latest information and communication technologies. The platform consists of a web-based application providing communication interface with monitoring devices of physiological variables, application for monitoring dietary intake, ad hoc electronic medical records, different communication channels, and an intelligent notification system. A 2-week feasibility study was conducted in 15 volunteers to assess the viability of the platform. Results: The website received 244 visits (average time/session: 17 min 45 s). A total of 435 dietary intakes were recorded (average time for each intake registration, 4 min 42 s ± 2 min 30 s), 59 exercises were recorded in 20 heart rate monitor downloads, 43 topics were discussed through a forum, and 11 of the 15 volunteers expressed a favorable opinion toward the platform. Food intake recording was reported as the most laborious task. Ten of the volunteers considered long-term use of the platform to be feasible. Conclusions: The PREDIRCAM platform is technically ready for clinical evaluation. Training is required to use the platform and, in particular, for registration of dietary food intake.
Why Empiricism Won't Work

Thought experiments provide us with scientific understanding and theoretical advances which are sometimes quite significant, yet they do this without new empirical input, and possibly without any empirical input at all. How is this possible? The challenge to empiricism is to give an account which is compatible with the traditional empiricist principle that all knowledge is based on sensory experience. Thought experiments present an enormous challenge to empiricist views of knowledge; so much so that some of us have (cheerfully) thrown in the towel and embraced good old fashioned platonism. I'll try to explain why one brand of empiricism, namely John Norton's argument view of thought experiments, won't work.
Effects of modified tall oil versus a commercial source of conjugated linoleic acid and increasing levels of modified tall oil on growth performance and carcass characteristics of growing-finishing pigs.

Two experiments were conducted to evaluate the effects of conjugated linoleic acid (CLA)-enriched feed additives for swine. These additives included a source of CLA that was commercially available (CLA-60) and modified tall oil (MTO). Experiment 1 used 36 barrows (initially 37.6+/-2.8 kg) to compare the effects of CLA-60 and MTO on growth performance and carcass characteristics of finishing pigs. The corn-soybean meal diets contained . 50% soybean oil (control), . 50% CLA-60, or . 50% MTO. Pigs fed CLA-60 had less (P = .03) ADG from 37.6 to 72.6 kg than the control pigs; otherwise, pigs fed either CLA-60 or MTO had growth performance similar (P > .15) to that of the control pigs. Pigs fed MTO grew faster (P = .03) and consumed more feed (P = .10) over the duration of the experiment (37.6 to 106.4 kg) than pigs fed CLA-60. Dietary treatment did not affect (P > .15) plasma triglycerides or carcass characteristics, but pigs fed either MTO or CLA-60 had greater saturation of fatty acids in the adipose tissue at the 10th rib than pigs fed the control diet. Experiment 2 used 80 barrows (initially 33.4+/-2.2 kg) to examine the effects of increasing levels of MTO on growth performance and carcass characteristics of finishing pigs. The corn-soybean meal diet contained 1% cornstarch, which was replaced with MTO to give dietary levels of . 25, . 50, or 1.00% MTO. Dietary treatment did not affect (P > .15) growth performance. Feeding increasing levels of MTO quadratically decreased (P = .02) average backfat thickness and longissimus muscle drip loss (P = .04) and quadratically increased longissimus muscle area (P = .07) and percentage lean (P = .03). Feeding MTO tended to increase belly firmness (P < .10) compared with pigs fed the control diet. These traits appeared to be optimized with . 50% MTO. In summary, pigs fed MTO had greater ADG, ADFI, and ending BW than pigs fed CLA-60. Feeding MTO does not appear to affect growth performance but improves carcass lean content and may additionally improve some aspects of meat quality in growing-finishing pigs.
Utility of Walk Tests in Evaluating Functional Status Among Participants in an Outpatient Cardiac Rehabilitation Program

Purpose: Although walk tests are frequently used in cardiac rehabilitation (CR), no prior study has evaluated the capacity of these measures to predict peak oxygen uptake during exercise testing ( O2peak). This study evaluated the interrelationship of objective measures of exercise performance (walk and exercise testing) among patients entering CR as well as a novel measure of functional status assessment for use in CR. Methods: Forty-nine patients (33 males) referred to an outpatient CR program were evaluated with objective measures of ambulatory functional status (peak oxygen uptake [ O2peak], 6-minute walk test [6MWT], and 60-ft walk test [60ftWT]). Results: All measures of functional status were moderately to highly intercorrelated (r values from 0.50 to 0.88; P values < .05). The relationship among measures differed by sex, but not by age or diagnosis. Among men, results were generally consistent with the full sample. Among women, the magnitude of correlations was generally lower and there was no relationship between O2peak and other measures. Conclusions: Measures of functional status, including O2peak, 6MWT, and 60ftWT, were highly correlated among CR patients, suggesting the plausibility of using them interchangeably to fit the needs of the patient and testing environment. Among women, walk tests may not be appropriate substitutes for O2peak. Because of the brevity of the 60ftWT, it may be particularly useful for measuring functional status in patients with greater symptoms and those with comorbidities limiting walking.
Hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage.

PURPOSE To evaluate hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage. METHODS Thirty patients with acute intracerebral hemorrhage were enrolled. Transcranial doppler was used to detect variables of bilateral middle cerebral arteria (MCA) including mean velocity (Vm) and pulsitility index (PI) before and after 125 ml and 250 ml mannitol infusion (0, 30, 60, 90, 120, 180, 240 min). RESULTS When 125 ml or 250 ml mannitol was infused in patients with acute intracerebral hemorrhage, Vm of bilateral MCA elevated, and reached the top at 30 min, and then decreased. PI decreased in the affected MCA (250 ml) and in the unaffected MCA (125 ml and 250 ml). CONCLUSION Mannitol infusion in patients with acute intracerebral hemorrhage can improve cerebral blood flow in bilateral hemispheres and decrease intracranial pressure in the hemorrhagic hemisphere (250 ml) and in the nonhemorrhagic hemisphere (125 ml and 250 ml).
Temperament influences endotoxin-induced changes in rectal temperature, sickness behavior, and plasma epinephrine concentrations in bulls

This study was designed to determine the influence of temperament on endotoxin-induced changes in body temperature, sickness behavior, and stress hormone concentrations in cattle. Brahman bulls were selected based on temperament score measured 28 d prior to weaning. In dwelling recording devices were used to monitor rectal temperature, and jugular catheters were used to collect blood samples to determine cortisol and epinephrine concentrations before and after LPS administration (0.5 μg/kg body weight). Temperamental bulls had the lowest peak rectal temperature and sickness behavior scores relative to the Calm and Intermediate bulls. Prior to the administration of LPS, Temperamental bulls had greater cortisol and epinephrine concentrations than Calm or Intermediate bulls. Cortisol concentrations increased following LPS administration but were not affected by temperament. Epinephrine concentrations peaked 1 h after LPS administration in Calm bulls. Temperamental bulls did not exhibit an epinephrine response to LPS challenge. These data demonstrate that the temperament of calves can modulate the physiological, behavioral, and endocrine responses of pre-pubertal Brahman bulls to endotoxin challenge. Specifically, temperament differentially affected the rectal temperature, sickness behavior and epinephrine, but not cortisol, responses to LPS challenge.
DEEP PERONEAL MOTOR NERVE CONDUCTION VELOCITY DISTRIBUTION AND CORRELATION BETWEEN NERVE CONDUCTION GROUPS AND THE NUMBER OF INNERVATED MUSCLE FIBERS

In this study, the distribution of peroneal-nerve conduction velocity was studied in 17 normal subjects, using the collision method. Paired supramaximal stimuli with predetermined interstimulus intervals (ISI) were applied at distal and proximal points of peroneal nerve and the resultant compound muscle action potentials (CMAPs) were recorded. The change in CMAP amplitudes and areas with ISI were deduced, and the relative number of fibers corresponding to each conduction velocity group (CVG) were computed. Conduction velocities of the peroneal motor nerve innervating the Extensor Digitorum Brevis (EDB) muscle were found to be in the range of 28-52 m/s and CVG innervating the greatest number appears to be in 40-48 m/s range, which consists of 70% of all fibers. These results show that, compared with the median motor nerve, deep peroneal motor nerve that innervates the EDB muscle consist of slow fibers.
The making of Tara Oceans: funding blue skies research for our Blue Planet

The Tara Oceans project emerged from an early romantic idea I had in 2000: organizing a sailing expedition in the wake of Darwin's voyage aboard the Beagle to popularize Biology. The original concept was mostly educational and media‐oriented. Many years later, in spring 2007, with the help of a few colleagues, a scientific dimension was added to the project, which was key to start motivating funders. The long search for support and for a suitable sailing vessel was finally successful, when in fall 2007 Eric met Etienne Bourgois and agnes b. , the founders of Tara Expeditions. This non‐profit organization runs the 110‐foot polar exploration schooner Tara since 2003, participates in scientific expeditions and promotes environmental awareness with a very efficient communication and artistic program to reach the public. Both the idea of a 3‐year around‐the‐world expedition to study pelagic plankton organisms and the urge to raise awareness about the serious environmental issues affecting oceans appealed to the organization. The synergy that would result from combining a solid scientific concept with a vigorous communication strategy convinced both parties to engage into a long‐term commitment. Together with a few adventurous colleagues, the first scientific meeting to plan the expedition was organized in Villefranche‐sur‐Mer in fall 2008. Inspired by the structure and functioning of EMBL, coordinators for various specialties were appointed. Specialists for the main domains of life (viruses, bacteria, archaea, protists and metazoans) were needed, as well as oceanographers, ecologists, molecular and cellular biologists, physicists and bioinformaticians, including experts on imaging, databases and sequencing. Each of the scientists involved in this early phase recruited additional colleagues in a wonderfully self‐organized process. With input from the different disciplines, we determined sampling zones, organisms' …
Obesidad: Tratamiento no farmacológico y prevención

La obesidad es un importante problema de salud en nuestros dias, por el riesgo aumentado de morbilidad y mortalidad, sobre todo por las enfermedades cardiovasculares que provoca. El objetivo de este trabajo fue actualizar los conocimientos acerca del tratamiento no farmacologico y la prevencion de la enfermedad. Se expuso que en el 95 % de los casos la obesidad es de origen exogeno o nutricional, y en el 5 %, de causa genetica o endocrina. En relacion con los factores geneticos, las investigaciones plantean las diferentes mutaciones que se acompanan de fenotipos obesos. Se senalaron los diferentes metodos empleados para el diagnostico de la obesidad, antropometricamente. Se afirmo que en la actualidad es muy utilizado el IMC y la relacion cintura/cadera. Se concluyo que el tratamiento de la obesidad supone modificaciones dieteticas, actividad fisica e intervencion conductual y/o psicologica y que la prevencion sigue siendo la accion fundamental para evitar su aparicion por lo que los esfuerzos de todos los medicos se deben dirigir hacia este problema de salud.
Human intrauterine parabiotic syndrome and its complications.

THE syndrome associated with intrauterine transfer of blood between uniovular twins has recently attracted clinical attention.1 2 3 4 5 6 7 8 9 10 As a consequence of blood transfer through anastomotic vessels in the of 2 additional pairs was also studied. Severe polyhydramnios often developed in the amniotic sac of the polycythemic twin. This led to premature delivery of at least 7 of the pairs (Table 1). Amniocentesis placenta 1 twin becomes polycythemic, and the other anemic. This feature resembles experimental parabiotic intoxication, but other features are unique because the parabiosis develops during intrauterine life. Polyhydramnios developing in the amniotic sac of the polycythemic twin often leads .
A força do legado transgeracional numa família

Resumo: Este artigo trata da forca da transmissao e manutencao do sofrimento psiquico ao longo de tres geracoes de uma familia, com base no approach transgeracional. Um paciente atendido individualmente pela analista permite retracar a heranca trans-historica que vigora em sua familia. Sua analise revelou que seu sofrimento estava engatado a pre-historia de seus familiares. O metodo psicanalitico de apreensao de elementos inconscientes fornece a base para o presente estudo de revisao teorica com ilustracao de caso clinico. Algumas construcoes verbais dessa familia servem como recurso para examinar o uso defensivo das representacoes e afetos, de modo a manter seu sofrimento psiquico. Este e relacionado as dificuldades do sistema das representacoes de representar situacoes traumaticas transgeracionais. Conceitos de varios autores tem fornecido importantes bases teoricas para as ideias da autora. Palavras-chave: heranca transgeracional, representacoes, psicanalise. THE FORCE OF THE TRANSGENERATIONAL LEGACY IN A FAMILY
Patients' expectancies and relearning as factors determining improvement in psychotherapy.

A group of psychiatric outpatients received either individual psychotherapy, group psychotherapy or minimal therapy for about 6 months. After 6 months the treatment experiences of the patients became increasingly varied. Patients were rated with respect to change in subjective discomfort and social ineffectiveness at 6 months and at regular follow-up intervals up to 2 years. It was found that at 6 months the average discomfort had markedly decreased, and that the decrease was the same regardless of kind or amount of treatment. Symptoms of anxiety and depression tended to be scored higher initially and to decline more than somatic complaints. Subsequent studies with these and similar patients showed that a similar drop in discomfort could be found within one week, or even in the course of a single interview. A significant improvement in social ineffectiveness also was found at 6 months. It was significantly greater for patients who had received group or individual therapy than for those in minimal therapy .
Dynamic Attribute-Based Access Control in Cloud Storage Systems

Cloud storage service allows data owner to store their big data in the cloud and provides data access to the users. As the cloud server is not trustworthy, we cannot rely on the server to conduct data access control. To protect data security and privacy, Attribute-Based Encryption (ABE) is a promising technique for data access control in cloud storage, because it provides data owner more direct control on access policies. However, there are two dynamic issues, namely attribute revocation and policy updating, that should be solved first before deploying ABE in practice. In this paper, we design a dynamic attribute-based access control scheme, which can solve the above two problems simultaneously. Besides, our scheme can support large universe of attributes, which makes it more available in cloud storage system. The proposed scheme is proved statically secure in random oracle model.
Hardware accelerators for the K-nearest neighbor algorithm using high level synthesis

Supervised machine-learning algorithms require relatively large amounts of runtime to perform training and/or classification. Therefore, a need exists to accelerate their runtime, especially for real-time applications. In this paper, we propose and compare several hardware accelerators for the K-Nearest Neighbor (K-NN) classification algorithm. The accelerators are developed using Xilinx Vivado High-Level Synthesis (HLS) and represent examples of semi-tightly coupled architectures. Our experimental results, based on standard benchmarks, show speedups ranging from 48x-168x.