Miracle-dz/UniFAR-FTUs huggingface dataset:
Gastrointestinal diseases in the paediatric age groups in Europe: epidemiology and impact on healthcare

As a whole, during the last 10 years, the prevalence of gastrointestinal infections has decreased, while that of chronic inflammatory bowel disease and food allergy has increased in Western Europe and Scandinavian countries. With the development of novel screening methods it has become apparent that coeliac disease and its associated consequences can now be considered as one of the most common digestive disorders in children in many European countries. Epidemiological differences remain between the east and west of Europe. Data based on large-scale epidemiological studies is still lacking regarding food allergy and surprisingly also regarding gastro-oesophageal reflux disease in children, apart from infants. In Europe, as in the USA, the increasing problems of obesity and constipation may be attributed to disturbances in dietary habits and nutritional intake.
Caracterização e Modelagem Temporal de Chamadas de Telefonia Móvel em Grandes Eventos

O uso cada vez maior de telefones celulares desafia as operadoras a evoluirem e melhorarem os seus servicos com base no comportamento de seus usuarios. Em particular, eventos de grande escala podem impor padroes que diferem fortemente daqueles observados normalmente no uso diario das redes das operadoras de telefonia celular. Este trabalho apresenta os impactos de jogos de futebol na carga de trabalho de uma rede de telefonia movel a partir do uso de uma metodologia proposta. Os resultados mostram a dinâmica da carga de trabalho no entorno do horario dos eventos e apresentam caracteristicas do aumento de uso dos servicos de voz da operadora em consequencia tanto do deslocamento dos participantes quanto da natureza do proprio evento.
The Influence of Host Species and Location in the Host Detection Ability of Tiphiid (Hymenoptera: Tiphiidae) Parasitoids

ABSTRACT Tiphia vernalis Rohwer and Tiphia popilliavora Rohwer are ectoparasitoids of root-feeding larvae of the Japanese beetle, Popillia japonica Newman, and oriental beetles, Anomala orientalis Waterhouse (Coleoptera: Scarabaeidae). Little is known about the influence of host species and location in the host detection ability of tiphiid wasps. In this study, we examined the response of female T. popilliavora wasps, an understudied Tiphia species, to potential host stimuli using dual choice tests in an observation chamber filled with soil. T. popilliavora wasps were able to successfully discriminate the trails containing body odor or frass of P. japonica grubs from trails without cues. Frass trails of P. japonica grubs elicited stronger responses than body odor trails. We also examined the preference of host cues by tiphiid wasps using dual choice behavioral assays. Both T. vernalis and T. popilliavora wasps did not show preference toward trails that either contained P. japonica or A. orientalis cues. In addition, we also determined the detection of host cues by tiphiid wasps in a dual-choice test for cues presented at varying soil depths. Wasps were able to successfully discriminate between the Y-tube arms with and without cues when the cues of P. japonica were buried at a depth of 2 cm. In contrast, both Tiphia species were unable to distinguish between the Y-tube arms with and without cues when the cues were buried at a depth of 5 cm. Thus, our findings suggest that once Tiphia wasps land on the ground, they can detect the presence of their specific hosts, just below the soil surface by exploiting the kairomones present in grub body odor trails and frass and once the wasps are in the soil, they use the same cues to direct themselves to the host grubs.
Design of wideband unit-cell element for 5G antenna arrays

The previous generations of cellular networks are almost packed in the UHF band with a frequency range of 300 MHz-3 GHz in the radio spectrum. Recently, the Ka-band is under investigation to be commercially used in next generation of cellular systems, due to the spectrum availability and the small size of the components. The main purpose of this paper is to design a wideband antenna element at 28 GHz, so that it can be used in the antenna arrays of next generation mobile networks. The proposed unit-cell is a proximity coupled stacked patch antenna. The antenna parameters and characteristics are investigated both through simulation and measurement. The antenna achieves a measured gain of 7.1 dB at 28 GHz. The measured impedance bandwidth and 1-dB gain bandwidth are 34.48 % and 17.4 %, respectively.
Continuous progesterone exposure associated with high contraction frequency in human term myometrial strips

It has been shown that progesterone slightly reduced the work of human term myometrial strips. In vitro 5α‐pregnane‐3,20‐dione and 3α‐hydroxy‐5α‐pregnan‐20‐one, two major extra‐hepatic metabolites of progesterone, had only minor effects or none at all. The myometrial strips were stored and superfused in a progestin‐free buffer until the onset of contractions when progestin superfusion was commenced. In vivo the human myometrium is never deprived of the influence of these steroids, either prior to or during labor. In the present investigation we studied whether progesterone and the two named progesterone metabolites would have a different effect when the myometrial strips were not deprived of steroid. Muscle biopsy samples from the lower uterine segment were immediately placed and stored in buffer containing progesterone, 5α‐pregnane‐3,20‐dione, or 3α‐hydroxy‐5α‐pregnan‐20‐one. The strips were then bisected; one half was superfused with progestin buffer, and the other half with plain buffer to serve for control purposes.
Diagnóstico de morte de pastagens de Brachiaria brizantha nas regiões de Araguaína, TO e Redenção, PA.

Ocorrencia de morte de pastagens de Brachiaria brizantha nas regioes de Araguaina, em Tocantins e Redencao, no sul do Para, motivou pesquisadores da Embrapa Gado de Corte a realizarem uma viagem de diagnostico, durante o periodo de 4 a 9 de marco de 1999. Constatou-se que a morte das pastagens ocorria em areas localizadas (reboleiras) das pastagens. Apesar de terem sido verificadas altas infestacoes de cigarrinhas-das-pastagens, bem como de cupins subterrâneos, em alguns locais, o excesso de agua em areas de depressao do terreno (condicao favoravel ao ataque de fungos nas raizes - principalmente do genero Rhizoctonia), associado a um estado geral de degradacao de pastagens por excesso de uso (manejo inadequado), foram consideradas as principais causas da morte de braquiaria nas regioes visitadas.
The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 122 cases of breast cancer.

OBJECTIVES To increase the efficacy and reduce the toxicity of cancer therapy. METHOD The DBM with MLT (melatonin), Retinoids, vitamins E, D3, and C has a differentiating, cytostatic, antiangiogenic, immunomodulating, factorially synergic effect, at the same time reinforcing those functions that Physiology considers essential for life. With Somatostatin and/or its analogues, the DBM has an antiproliferative effect, negatively regulating the most powerful mitogenic molecule (GH), receptorially co-expressed and interactive with Prolactin, inhibited by Cabergoline and/or Bromocriptin. The negative regulation of GH extends directly to the GH-dependent growth factors. In breast cancer, the DBM entails the use of estrogen inhibitors and minimal apoptotic, non-cytotoxic and non-mutagenic doses of Cyclophosphamide or Oncocarbide, the tolerability of which is enhanced by MLT and the vitamins in the DBM. RESULTS Complete and stable cure of 4 cases, and rapid regression of the tumour in another 5 cases with just the DBM (first-line therapy), without surgical intervention. No disease recurrence with the use of the DBM as adjuvant therapy. Five-year survival of 50%, of stage IV cases, considerably higher than the data reported in the literature. A more or less generalised improvement in the quality of life, without any significant and/or prolonged toxicity. CONCLUSIONS The acknowledgement of the still underestimated scientific evidence, such as the multiple antitumoral mechanisms of action of MLT, the negative regulation of the interactive mitogens GH-GF (GH-dependent growth factors), Prolactin and estrogens, together with the differentiating and homeostatic action of retinoids and Vitamins E, D3, and C and MLT, made it possible to achieve these results. An essential aspect of the mechanism of action on the clinical response is the factorial synergy of the DBM components.
CXCR4 signaling identifies a role for IFT2 in ER-negative breast cancers

Commentary to: ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer Hitesh Appaiah, Poornima Bhat-Nakshatri, Rutika Mehta, Mangesh Thorat, Sunil Badve and Harikrishna Nakshatri
Field surveys on coccidial infection in broilers in Japan--results obtained in spring and summer in 1973.

Field surveys on coccidial infection in Japanese broilers were performed with187 fecal samples collected from 29 prefectures in March (spring season) and June (rainyor summer season) in 1973.Species identification was carried out by two methods; examination of oocysts morpholo-gy and chicken passage test. Based on the morphological characters of the oocyst type, genus Eimeria was classified into four types, acervulina, brunetti, maxima, and tenella.Oocysts were detected from 73% of the samples tested in March. Single and mixed infec-Lion with the acervulina type were found in 66% of all the samples tested, or in 90% of theinfected samples, and those with the tenella type in 28% or in 38%. The maxima typewas detected at a high rate. Similar results were obtained in the survey conducted in June.Neither seasonal nor regional difference was observed in the distribution of the oocysttypes. A high rate of infection and large OPG values were shown by chicken from 31 to70 days of age.It was confirmed that Eimeria acervulina and E. maxima could be identified from themorphology of oocysts. The chicken passage test was required to distinguish the oocystsof E. tenella, E. necatrix, and E. praecox from those of tenella type in the fecal samples.Those three species were distributed all over Japan without restriction.No E. brunetti was detected by either of the methods used.
Metachromatic Leukodystrophy: Recent Research Developments

Metachromatic leukodystrophy is a lysosomal storage disorder caused by the deficiency of arylsulfatase A, causing the storage of the sphingolipid sulfatide. The disease is characterized by a progressive demyelination, which results in severe, finally lethal, neurologic symptoms. Genetically, the disease is heterogeneous, most mutant alleles are private, and only three have a frequency worth mentioning. An arylsulfatase A—deficient knockout mouse displays some of the disease features seen in patients but does not show the widespread demyelination characteristic of the disease. Nevertheless, this animal model was used to investigate the therapeutic potential of bone marrow stem cell—based gene therapy. Although treated animals show considerable arylsulfatase A activity in many tissues, including the brain, the effect on sulfatide storage was disappointing. Only in the kidney and liver of animals with very high enzyme levels was lipid storage positively affected. In particular, no effect was seen in the brain. These results suggest that bone marrow stem cell—based gene therapy could be of limited value in the treatment of this disease. The pathogenesis of the disease is poorly understood. It is not yet known how sulfatide storage negatively affects the metabolism of the oligodendrocyte. The amount and distribution of various proteins in the myelin of arylsulfatase A—deficient mice were investigated. It was shown that the myelin protein, myelin and lymphocyte protein (MAL), is reduced in deficient animals and that the myelin protein proteolipid displays an altered distribution within the myelin membranes. Possibly, these alterations contribute to the development of demyelination in this disease. (J Child Neurol 2003;18:591—594).
12 Wake-Up-Word Speech Recognition

Speech is considered one of the most natural forms of communications between people (Juang & Rabiner, 2005). Spoken language has the unique property that it is naturally learned as part of human development. However, this learning process presents challenges when applied to digital computing systems. The goal of Automatic Speech Recognition (ASR) is to address the problem of building a system that maps an acoustic signal into a string of words. The idea of being able to perform speech recognition from any speaker in any environment is still a problem that is far from being solved. However, recent advancements in the field have resulted in ASR systems that are applicable to some of Human Machine Interaction (HMI) tasks. ASR is already being successfully applied in application domains such as telephony (automated caller menus) and monologue transcriptions for a single speaker. Several motivations for building ASR systems are, presented in order of difficulty, to improve human-computer interaction through spoken language interfaces, to solve difficult problems such as speech-to-speech translation, and to build intelligent systems that can process spoken language as proficiently as humans. Speech as a computer interface has numerous benefits over traditional interfaces using mouse and keyboard: speech is natural for humans, requires no special training, improves multitasking by leaving the hands and eyes free, and is often faster and more efficient to transmit than the information provided using conventional input methods. In the presented work, in Section 2, the concept of Wake-Up-Word (WUW) is being introduced. In Section 3, the definition of the WUW task is presented. The implementation details and experimental evaluations of the WUW-SR system are depicted in Section 4. The WUW recognition paradigm partially applied to general word recognition is presented in Section 5. A developed data collection system from the DVD’s of movies and TV series is presented in Section 6. Concluding remarks and future work is provided in Section 7.
CHANGES OF INTRAOCULAR PRESSURE AFTER INTRAVITREAL INJECTION OF BEVACIZUMAB (AVASTIN)

Purpose: To determine changes and need to monitor intraocular pressure (IOP) following intravitreal injection of bevacizumab (Avastin). Methods: Seventy patients (122 injections) underwent an intravitreal injection of Avastin for exudative age-related macular degeneration treatment. Forty-one eyes (59%) had single injection, 29 eyes (41%) had repeated injections. IOP was measured before and after Avastin injection at 3, 10, and 15 minutes. Twenty-nine eyes were evaluated for baseline IOP changes after multiple injections. Statistical analysis was performed. Results: Baseline mean IOP was 15.17 ± 3.42 mm Hg, with range from 08 mm Hg to 23 mm Hg. Postinjection 3 minutes the IOP had risen to a mean of 36.27 ± 5.1 mm Hg and fell spontaneously to a mean of 24.56 ± 5.9 mm Hg at 10 minutes. Ten eyes (14%) needed 15 minutes to drop below 30 mm Hg. All eyes were below 30 mm Hg at 15 minutes. No significant change between multiple baseline IOP measurements was detected. Conclusion: Avastin injections caused a predictable probably volume-related rise in IOP which never occluded the central retinal artery and which spontaneously fell to below 30 mm Hg in all eyes within 15 minutes. This strong safety profile provides guidelines on monitoring IOP after Avastin injections. There was no IOP change after multiple injections.
Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance.

BACKGROUND Caveolin-1, a key component of plasma membrane caveolae, has been implicated in the regulation of cancer cell growth and survival. Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a ligand-activated nuclear receptor which plays a pivotal role in many cellular processes. Activation of PPARgamma by its ligand rosiglitazone upregulates caveolin-1 mRNA and protein in human carcinoma cells. MATERIALS AND METHODS We have used specific signaling inhibitors to dissect the mechanisms of caveolin-1 mRNA and protein induction by rosiglitazone, determined by RT-PCR and Western blotting, respectively. ROS generation was measured by flow cytometry and cell survival was determined by the MTT assay. RESULTS We show that in HT-29 human colon cancer cells the induction ofcaveolin-1 by rosiglitazone is inhibited by the EGF receptor (EGFR) blocker AG1478. Moreover, rosiglitazone stimulates EGFR phosphorylation, while direct activation of EGFR by EGF up-regulates caveolin-1 mRNA. Inhibitors of Src and the Mek1-Erk1/2 and p38 MAP kinase pathways also inhibit up-regulation of caveolin-1 by rosiglitazone. Furthermore, rosiglitazone stimulates formation of superoxide anions, whereas induction of caveolin-1 expression by rosiglitazone is attenuated by the antioxidant N-acetyl-cysteine. Finally, rosiglitazone increases the resistance of HT-29 cells to doxorubicin and to hydrogen peroxide. The caveolin-1 gene promoter lacks a canonical PPARgamma response element (PPRE) and a PPRE-reporter construct is not sensitive to EGF or EGFR inhibition. CONCLUSION Our findings indicate that up-regulation of caveolin-1 by rosiglitazone requires superoxide formation and the activation of Src, EGFR, and the Mek1-Erk1/2 and p38 MAP kinase pathways. We suggest a novel mode of action of PPARgamma ligands in the regulation of caveolin-1, and possibly other genes devoid of a PPRE in their promoters, which involves the coordinate activation of PPARgamma and intracellular signaling pathways.
Capacity analysis of adaptive multiuser frequency-time domain radio resource allocation in OFDMA systems

In this paper, we present the adaptive multiuser frequency-time domain radio resource allocation model which adaptively allocates the radio resource jointly in the frequency and time domain to exploit the frequency diversity and time diversity as well as multiuser diversity. Then we give an in-depth capacity analysis of the proposed radio resource allocation with frequency-time domain power adaptation in the downlink OFDMA systems and draw a comparison with the conventional frequency domain resource allocation method. Simulation results show that: 1) the proposed resource allocation method achieves much higher spectral efficiency than the conventional frequency-domain resource allocation; and 2) for the proposed two-dimensional allocation method, the performance of water-filling power allocation is almost the same as that of the equal power allocation, especially when the number of user is large
Short communication Identification of stem cell marker-positive cells by immunofluorescence in term human amnion

The placenta contains different populations of stem/progenitor cells such as mesenchymal, hematopoietic, trophoblastic and pluripotent stem cells. Although some tissue-specific stem cells are restricted to particular parts of the placenta, the localization of embryonic stem cell-like cells in term human placenta has not been determined. We have used immunofluorescence staining techniques with antibodies to pluripotent stem cell antigens, SSEA-3, SSEA-4, TRA 1-60 and TRA 1-81, and confocal microscopic analysis to identify and localize stem cells within the placenta. Stem cell marker-positive cells were found in amnion but not in choriodecidua, tissues known to contain hematopoietic and trophoblastic stem cells. Amniotic mesenchymal cells did not react with these pluripotent stem cell markers, while all amniotic epithelial cells reacted with at least one antibody. The TRA 1-60 and TRA 1-81 positive cells were solitary and present throughout the surface of amniotic membrane without a specific pattern of distribution, whereas SSEA-3 was negative and SSEA-4 was weakly positive on all amniotic epithelial cells. These data suggest that the human amnion contains stem cell-like cells at different states of differentiation. Human term amnion may be useful source of pluripotent stem cells for regenerative medicine. © 2007 Elsevier Ireland Ltd. All rights reserved.
Hepatic lesions in cattle caused by experimental infection of Fusobacterium necrophorum.

Inoculation of Fusobacterium necrophorum into the portal venous system of cattle resulted in the formation of microabscesses and disseminated microthrombi in the liver. The microabscesses expanded with multiplication of F. necrophorum, resulting in the formation of coagulative necrosis. The areas were encapsulated with granulation tissues. The development of hepatic lesions was partially associated with intravascular coagulation in the liver.
Naturally Occurring Auxin Transport Regulators

The process of polar auxin transport, central to a plant's auxin relations, can be inhibited by a group of synthetic compounds that apparently act by binding to a plasma membrane protein known as the naphthylphthalamic acid (NPA) receptor. No endogenous ligand to the NPA receptor, capable of affecting polar auxin transport in plants, has yet been found. It is now shown that a group of flavonoids-including quercetin, apigenin, and kaempferol—can specifically compete with [3H]NPA for binding to its receptor and can perturb auxin transport in a variety of plant tissues and transport systems in a manner closely paralleling the action of synthetic transport inhibitors. Because the active flavonoids are widely distributed in the plant kingdom and exert their effects at micromolar concentrations approximating likely endogenous levels, they may act as natural auxin transport regulators in plants.
The Role of Solvent-Accessible Leu-208 of Cold-Active Pseudomonas fluorescens Strain AMS8 Lipase in Interfacial Activation, Substrate Accessibility and Low-Molecular Weight Esterification in the Presence of Toluene

The alkaline cold-active lipase from Pseudomonas fluorescens AMS8 undergoes major structural changes when reacted with hydrophobic organic solvents. In toluene, the AMS8 lipase catalytic region is exposed by the moving hydrophobic lid 2 (Glu-148 to Gly-167). Solvent-accessible surface area analysis revealed that Leu-208, which is located next to the nucleophilic Ser-207 has a focal function in influencing substrate accessibility and flexibility of the catalytic pocket. Based on molecular dynamic simulations, it was found that Leu-208 strongly facilitates the lid 2 opening via its side-chain. The KM and Kcat/KM of L208A mutant were substrate dependent as it preferred a smaller-chain ester (pNP-caprylate) as compared to medium (pNP-laurate) or long-chain (pNP-palmitate) esters. In esterification of ethyl hexanoate, L208A promotes a higher ester conversion rate at 20 °C but not at 30 °C, as a 27% decline was observed. Interestingly, the wild-type (WT) lipase's conversion rate was found to increase with a higher temperature. WT lipase AMS8 esterification was higher in toluene as compared to L208A. Hence, the results showed that Leu-208 of AMS8 lipase plays an important role in steering a broad range of substrates into its active site region by regulating the flexibility of this region. Leu-208 is therefore predicted to be crucial for its role in interfacial activation and catalysis in toluene.
Asymptotic results for the random sequential addition of unoriented objects.

Asymptotic kinetics for random sequential addition of unoriented nonspherical objects is characterized by an algebraic time dependence. By studying 1 D systems, we show that the exponents describing the random sequential addition of objects with and without proper area are not simply related : whereas the asymptotic behavior for rectangles follows the expected t -1/2 law, the long-time kinetics for infinitely thin line segments is governed by a nontrivial, irrational, exponent (t √ 2-1 ) which results from a competition between creation and destruction of targets in the asymptotic regime.