Miracle-dz/UniFAR-FTUs huggingface dataset:
Frequency domain based identification of processes using limit cycle information

In this paper, general expressions for the identification of various processes in terms of a stable and unstable first order plus dead time (FOPDT) models are derived. During the identification test, a nonlinear device (relay) is connected to an unknown process through a feedback path which yields sustained oscillations known as limit cycle. The equivalent gain of an asymmetrical relay is approximated by describing function (DF) approach and further used in the deduction of mathematical expressions for process identification. When the process output is subjected to measurement noise, multiple switching at the relay output brings chattering at the output. Therefore, a Fourier series based curve fitting method is utilized in order to retrieve a clean limit cycle output. Further, to show the supremacy of the proposed method comparisons between estimated and actual process models are drawn using frequency response plots.
Role of CD21 antigen in diffuse large B‐cell lymphoma and its clinical significance

Recent advances in immunological and molecular technology have prompted proposals to change tumour classification and treatment strategies. Cell surface antigens are now easy to access, and tumour origins and clinical characteristics are now readily identifiable. However, in diffuse large B‐cell lymphoma (DLBCL), one of the heterogeneous forms of haematological malignancy, the clinical significance of tumour surface antigens has not been well documented. We analysed the tumour surface antigens of 50 tumours from newly diagnosed DLBCL patients by flow cytometry in accordance with their clinical characteristics and followed the patients for a median 3·7 years. Statistical analysis showed that CD21 expression was significantly negatively associated with mortality in DLBCL (CD21 negative versus positive; relative risk = 2·36, P < 0·05). As a result of these clinical observations, we generated CD21‐overexpressed (CD21+) lymphoma cell lines after gene transfection and analysed tumour cell growth in vivo in immunocompromised mice. Mice challenged with vector‐only transfectants and parental cells as controls died within 50 d. In contrast, mice injected with CD21+ transfectants exhibited significantly reduced tumour growth and 83% survived long term (versus control groups; P < 0·05). Interestingly, all established CD21+ transfectants (six clones from different bulks) showed homotypic aggregation during in vitro cell culture, and anti‐CD21 antibodies did not block this aggregation. Expression of CD21 is strongly associated with increased survival in DLBCL in vivo. CD21 expression may be indirectly concerned with the expression of additional cell adhesion molecules.
The Impact of Leadership on Student Learning

This study aims at shedding light on the impact of leadership on student learning. To start with, there has to be a definition of the concept “leadership” which may be considered a complex one. Leadership has two functions; the first is “giving directions” and the second is “having influence”. But this definition is too narrow for the concept “leadership” which entails a large responsibility for those who are in charge for conducting things. But when it comes to leadership in a teaching institute, things totally change whereby the responsibility is doubled. Therefore, leadership in teaching works towards both improving learning and teaching at the same time. High quality leaders may achieve this impact on the teaching/learning process through establishing clear directions for everyone to follow, providing teachers with training that will enhance their teaching techniques as well as finding suitable conditions in order to help both teaching and learning.
An RNA molecule copurifies with RNase P activity from Xenopus laevis oocytes.

Utilizing a procedure for the purification of RNase P from Xenopus laevis germinal vesicle (GV) extracts, according to which the contamination by a large, cytoplasmic, cylindrical structure (1) is avoided, we demonstrate that the X.laevis enzyme, like the HeLa RNase P, is precipitated by anti-Th antibodies and an RNA molecule (XL RNA), 320 nucleotides long, copurifies with the activity. The sequence of XL RNA is 60% homologous to HeLa H1 RNA, therefore the two molecules seem related.
High-density lipoproteins: a therapeutic target for atherosclerotic cardiovascular disease

Despite great progress being made during the last two decades in cardiovascular disease prevention, especially by lowering low-density lipoprotein-cholesterol with statins, cardiovascular events continue to occur. Plasma high-density lipoprotein (HDL) exerts multiple protective effects on the arterial wall, through promotion of reverse cholesterol transport, prevention of endothelial dysfunction and inhibition of lipid oxidation. Therapeutic interventions raising plasma HDL levels or directly mimicking its beneficial effects represent the next frontier in the prevention and treatment of cardiovascular disease.
From endemic goitre to iodine deficiency disorders.

Endemic goitre occurs when the prevalence of thyroid enlargement in the population of an area exceeds 10%. With few exceptions its cause is iodine deficiency superimposed on other goitrogenic factors normally present and responsible for sporadic goitre. Iodine deficiency causes significant health problems and so, the term iodine deficiency disorders (IDD) has been introduced. The earliest sign of IDD is goitre, but these disorders also include cretinism, neonatal hypothyroidism and congenital defects, as well as retardation of mental and physical development etc. IDD are a worldwide problem: WHO estimates that substantially more than 800 million people are at risk and more than 190 millions suffer from IDD; over 3 million people have cretinism and in the largest and worst affected areas many millions suffer from mental and physical developmental defects. IDD can be totally eliminated by prophylaxis using iodine administered in salt, oil or some other vehicle. Problems over preventing iodine deficiency relate to difficulties in the handling and distribution of the iodized vehicle in some parts of the world and on the political will to introduce preventive schemes. In only a very few areas does the presence of goitrogenic agents in the environment cause endemic goitre despite adequate iodine supply. In a limited number of places excessive iodine from seaweed used as staple food results in endemic goitre.
A Proposed General Formula to Create and Analyze Baking Recipes

A mathematical formula for characterizing baking recipes is presented as part of the 2017 Computer Cooking Contest Open Challenge. The formula produces three characteristic values, which along with common knowledge rules and classification, form the basis of two computer applications: Random Recipe Generator, which creates recipes, and Recipe Report Card, which analyzes recipes.
ingle-wavelength reflected confocal and multiphoton icroscopy for tissue imaging

Both reflected confocal and multiphoton microscopy can have clinical diagnostic applications. The successful combination of both modalities in tissue imaging enables unique image contrast to be achieved, especially if a single laser excitation wavelength is used. We apply this approach for skin and corneal imaging using the 780-nm output of a femtosecond, titanium-sapphire laser. We find that the near-IR, reflected confocal RC signal is useful in characterizing refractive index varying boundaries in bovine cornea and porcine skin, while the multiphoton autofluorescence MAF and second-harmonic generation SHG intensities can be used to image cytoplasm and connective tissues collagen , respectively. In addition, quantitative analysis shows that we are able to detect MAF from greater imaging depths than with the near-IR RC signal. Furthermore, by performing RC imaging at 488, 543, and 633 nm, we find that a longer wavelength leads to better image contrast for deeper imaging of the bovine cornea and porcine skin tissue. Finally, by varying power of the 780-nm source, we find that comparable RC image quality was achieved in the 2.7 to 10.7-mW range. © 2009 Society of Photo-Optical Instrumentation Engineers. DOI: 10.1117/1.3247157
A 60 GHz MMIC dual-quadrature mixer in pHEMT technology for ultra wideband IF signals and high LO to RF isolation

A 60 GHz MMIC dual-quadrature mixer (DQM) has been designed, fabricated in a commercial pHEMT MMIC process and characterized with probed measurements. A measured down conversion loss (L/sub C/) of 8.5 /spl plusmn/ 1 dB over the frequency range 47 to 67 GHz is obtained with an LO to RF isolation better than 20 dB and 8 dBm of LO power. Measurements verify that the IF bandwidth is truly ultra wideband with a total IF bandwidth of 11.5 GHz. Thus, with a fixed LO signal of 58 GHz, the RF band between 53 and 64.5 GHz can be down converted directly to the base band while maintaining a high LO to RF isolation. Single resistive mixers are used for the actual down conversion which results in a high IIP3 figure of 20 dBm and virtually no DC power consumption. Furthermore, the DQM exhibit very low reflection coefficients at the RF and LO ports due to the dual-quadrature topology.
Characterization of the Erwinia chrysanthemi osmoprotectant transporter gene ousA

Growth of Erwinia chrysanthemi in media of elevated osmolarity can be achieved by the uptake and accumulation of various osmoprotectants. This study deals with the cloning and sequencing of the ousA gene-encoded osmoprotectant uptake system A from E. chrysanthemi 3937. OusA belongs to the superfamily of solute ion cotransporters. This osmotically inducible system allows the uptake of glycine betaine, proline, ectoine, and pipecolic acid and presents strong similarities in nucleotide sequence and protein function with the proline/betaine porter of Escherichia coli encoded by proP. The control of ousA expression is clearly different from that of proP. It is induced by osmotic strength and repressed by osmoprotectants. Its expression in E. coli is controlled by H-NS and is rpoS dependent in the exponential phase but unaffected by the stationary phase.
Learning and courtship in Drosophila: two stories with mutants.

Victorian ladies and gentlemen cultivated waltzing mice and tumbling pigeons as parlor pets. They derived mild social amusement from the inbred animals' curious behavior, unmindful of the hereditary ataxias and seizures that caused it. Present day fanciers of behavioral mutants continue to be amused by their organisms, but as biologists they are concerned above all with the etiology of curious behavior. Other things have changed as well. Simple organisms bear­ ing single gene mutations have replaced complex, inbred strains, and the emphasis is on using these new mutants to dissociate complex behaviors and the neuronal processes that underlie them. Recently, the cumulative effect of many experiments with many mutations, brought to bear on a few well-defined questions, has helped promote some of these studies from promising curiosities to coherent stories. Here we concen­ trate on two of these, in the organism we know best. In one case, mutations that perturb learning and memory in well-defined ways have led directly to the underlying biochemistry. In another, mutations and mosaics in combination with behavioral studies have resolved an ethologically complex behavior in unprecedented detail, showing the brain regions, sensory cues, and experiential determinants of many of its steps. For more comprehensive reviews, see Hall and colleagues (1982) and Hall (1982).
A WR-6 rectangular waveguide to microstrip transition and patch antenna at 140 GHz using low-cost solutions

A new WR6 rectangular waveguide to microstrip transition is developed based on the concept of slot coupling. The transition is designed having in mind the great limitations that exist in these high frequency ranges. A low- cost implementation is also pursued, avoiding complicated multilayer and assembly structures. As an example of application, a microstrip patch antenna is also designed at the WR6 center frequency, 140 GHz. The interconnection system here developed can help in measurement procedures of further microstrip radiating structures or can act as feed line for planar antennas. The transition is designed by means of 3D finite element electromagnetic simulators and built using common photolitography processes with commercial components. Measurements show a bandwidth of nearly 7 GHz for a return loss below -10 dB and low insertion loss around -0.7 dB within the transition bandwidth.
CHiME Challenge: Approaches to Robustness using Beamforming and Uncertainty-of-Observation Techniques

While much progress has been made in designing robust automatic speech recognition (ASR) systems, the combination of high noise levels and reverberant room acoustics still poses a major challenge even to state-of-the-art systems. The following paper describes how robust automatic speech recognition in such difficult environments can be approached by combining beamforming and missing data techniques. The combination of these two techniques is achieved by first estimating uncertainties of observation in the beamforming stage, either in the time or frequency domain, and subsequently transforming these observations with associated uncertainties to the domain of speech recognition. This strategy allows the use of reverberation-insensitive cepstral features, which can still be decoded robustly with the help of uncertainty information gained from the beamforming front end. In this paper, we investigate a number of different preprocessing options with the somewhat surprising result that a simple fixed delay-and-sum beamformer and a null-steering beamformer, when combined with uncertainty decoding techniques, resulted in the most robust design among a much wider set of investigated techniques. Index Terms: robustness, automatic speech recognition, beamforming, uncertainty decoding
Comparison of the actions of adenosine at pre‐ and postsynaptic receptors in the rat hippocampus in vitro.

1. Intracellular microelectrode recordings were used to study the cellular location, the receptor pharmacology, and the mechanism of action of adenosine on pyramidal cells and presynaptic axonal endings in area CA3 of organotypic hippocampal slice cultures. 2. Adenosine (bath applied at 50 microM) caused a 10‐15 mV hyperpolarization of CA3 cells, as well as a 75‐100% decrease in the amplitude of excitatory and polysynaptic inhibitory postsynaptic potentials (EPSPs and IPSPs). Adenosine had no effect on the amplitude of monosynaptic IPSPs elicited in the presence of excitatory amino acid receptor antagonists, but did reduce the amplitude of isolated EPSPs, elicited after blocking GABAA receptors and reducing subsequent epileptic bursts with excitatory amino acid receptor antagonists. These data indicate that adenosine receptors are located on excitatory, but not inhibitory, presynaptic elements. 3. The A1 receptor antagonist 8‐cyclopentyl‐1,3‐dipropylxanthine (DPCPX, bath applied at 200 nM) blocked the pre‐ and postsynaptic actions of adenosine. DPCPX had no effect on the amplitude of control synaptic responses, suggesting that there is no tonic activation of adenosine receptors in hippocampal slice cultures under control conditions. The A1 receptor agonists R‐N6‐phenylisopropyladenosine (R‐PIA) mimicked all pre‐ and postsynaptic actions of adenosine. 4. Pertussis toxin pretreatment (500 ng/ml for 48 h) prevented adenosine from activating postsynaptic K+ conductance, but not from inhibiting EPSPs. In contrast, stimulation of protein kinase C with phorbol ester (phorbol 12, 13‐dibutyrate, 1 microM for 10 min) reduced the presynaptic, but not the postsynaptic, actions of adenosine. 5. Barium (bath applied at 1 mM) blocked the adenosine‐activated K+ conductance, but not the inhibition of isolated EPSPs by adenosine. 6. Adenosine at 0.03‐1 microM reduced the frequency of, or blocked, spontaneous epileptiform bursting produced by bicuculline. DPCPX (200 nM) increased the rate of spontaneous bursting, consistent with a tonic activation of adenosine receptors during hyperactivity, and led to the development of prolonged ictal‐like bursts, suggesting that the endogenous release of adenosine may contribute to the termination of epileptic bursts. 7. We conclude that adenosine acts at pre‐ and postsynaptic receptors which are pharmacologically indistinguishable. Postsynaptically, adenosine increases a barium‐sensitive K+ conductance via a pertussis toxin‐sensitive GTP‐binding protein. The presynaptic action of adenosine must, however, be mediated by some other mechanism.
Dissociation between the time course of ethanol and extracellular dopamine concentrations in the nucleus accumbens after a single intraperitoneal injection.

BACKGROUND Dopamine release in the nucleus accumbens has been linked to the reinforcing effects of ethanol, but the time course or relationship of this response to ethanol concentrations in the brain has not been studied. METHODS Various doses of ethanol (0-2.0 g/kg) were administered intraperitoneally to male Sprague Dawley rats, and dopamine and ethanol were simultaneously analyzed in dialysate samples from the nucleus accumbens. A separate study to compare the ethanol-induced dopamine response in male and female rats was carried out by using a 1 g/kg intraperitoneal dose of ethanol. RESULTS In male rats, 1 and 2 g/kg ethanol significantly increased dialysate dopamine by 40% over basal, whereas 0.25 and 0.5 g/kg ethanol produced a nonsignificant 20% increase. Dialysate ethanol concentrations exhibited a curvilinear decline after reaching peak levels for the lower doses but showed a linear decrease after 1 and 2 g/kg. There was a dissociation between the time courses of extracellular dopamine and ethanol after 1 and 2 g/kg ethanol treatment. The dopamine response returned to basal within 90 min, whereas the ethanol concentrations remained elevated. In a separate study that compared male and female rats, the ratio of the dopamine response over basal to the dialysate ethanol concentrations was significantly decreased at 60 min after an injection of 1 g/kg. However, there were no differences between males and females. CONCLUSIONS The dissociation between dopamine and ethanol levels may reflect the development of acute tolerance to ethanol-induced dopamine release in the nucleus accumbens within the time course of a single acute injection. Given the strong links between dopamine and ethanol reinforcement, our findings may be relevant for understanding the time course of ethanol's reinforcing effects in vivo.
EL ORDENADOR COMO HERRAMIENTA INTELECTUAL

One of the idea more divulga from computers insert in the education schools and currículum, has been and being posibly, is the idea about themselves have such as tools of development cognitiva skills of the students; in fact aas tools of developments of the mind. In this report, we are showing an investigation about programme BASIC lan-guaje have an influence on two cognitions style: DIC and Al.
Ureteral stenosis secondary to encrustation by urea-splitting Corynebacterium urealyticum in a kidney transplant patient.

resulted lyticum ; struvite in immediate of and subsequent pyelography through the nephrostomy catheter revealed pelviureteral stenosis and multiple Introduction irregularities along the entire ureter. Surgical removal of the ureter of the graft was carried out. The recipient’s right kidney was nephrectomized and pyelo-pyelic ana- Kidney transplant recipients are susceptible to urinary stomosis between graft pyelon and recipient pyelon tract infection by Corynebacterium urealyticum . It may was carried out. The excised ureter showed multiple cause encrusting pyelitis and cystitis. stenosis; by histological examination, non-speciﬁc We draw attention to another potential localization chronic inﬂammation with crys- and complication of urinary tract C. urealyticum infec-tals noted. tion, i.e. pelviureteric
Recovery and Maintenance of Live Amphipods at a Pressure of 580 Bars from an Ocean Depth of 5700 Meters

Amphipods were collected from an ocean depth of 5700 meters in a windowed pressure-retaining trap, kept alive in the trap for as long as 9 days aboard ship, and transported to a land laboratory. Observations suggest that the animals can easily tolerate decompressions of 29 percent and briefly of 70 percent of the value of 580 bars, the pressure of their natural habitat. The average pleopod beat frequency was 106 beats per minute. Evidence suggests that food (fish bait) can have at least a 4-day residence time in the gut of these animals.
Adaptive online fault detection on network-on-chip based on packet logging mechanism

The shrinking size of transistors and on-chip interconnects contribute to increasing probability of on-chip faults. Fault tolerance is one of the key features in Network-on-Chip (NoC) architecture. Current NoCs use Error Detection and Correction (EDC) and acknowledgement mechanisms for fault and error controls. In order to maintain system functionality in presence of the faults, adapting error detection and correction based on changing error probability is required. Adapting fault detection techniques based on error probability helps NoC to achieve improved fault tolerance. End-to-end (E2E) EDC works better at low error probability whereas switch-to-switch (S2S) works better at high error probability condition. This thesis proposes an adaptive fault detection and fault diagnosis based on Negative acknowledgement (NACK) logging mechanism. In the first part, this thesis proposes a PL-Adaptive method where NoC routers are able to switch between E2E and S2S EDC depending on changing error probability. Each router tracks transmitted packets and NACK packets to continuously monitor its fault level. In the second part, this thesis proposes fault type classification of router and link faults. Based on experimental results by using constant uniform traffic pattern, our proposed PL Adaptive method gives better average latency than using only E2E or S2S. By evaluating the transmission latency with single error in a single path, our proposed PL-Adaptive method is able to achieve latency reduction in the range of [13% - 50%] compared to only S2S or E2E mechanism. Moreover, based on smaller decay rate and error probability in the range of [5x10-5-10-1], smaller threshold increases the higher probability to detect fault and error. PL-Adaptive method is able to detect faults and error up to 96%. Besides, our proposed PL-Adaptive method allows NoC routers to adapt with dynamic packet error probability and can identify router and link faults
Identification, assessment and management of new and re-emerging animal-related risks: UK perspective

Veterinary surveillance programmes aim to reduce the burden to the public, livestock and wider society posed by animal-related ‘risks’ (referred to as ‘threats’ later in the paper in line with a definition used by the European Food Safety Authority) including the re-emergence of diseases believed absent or eradicated. To achieve this, it is important to have a systematic approach to identifying and dealing with such threats rapidly and effectively. This paper describes the transparent, systematic and auditable process used for identifying, assessing, escalating and prioritising new and re-emerging animal-related threats in the UK. This has been achieved through the establishment of a Veterinary Risk Group in late 2009.
Game , Set , Match-LSTM : Question Answering on SQUaD

In this paper, we investigate the problem of answering textual questions based on a context paragraph that contains the answer. For our dataset, we use the Stanford Question Answering Dataset (SQuAD) [1]. Our approach is based on the MatchLSTM and Answer Pointer architecture described by Wang and Jiang [3]. Our final model achieves an F1 of 50.5% and an EM of 38.8% on the test set, which is on par with a strong logistic regression model.