Miracle-dz/UniFAR-FTUs huggingface dataset:
Child-spanking at age 5 may have a detrimental effect on child externalising behaviour and cognitive development at age 9

Commentary on: Mackenzie MJ, Nicklas E, Waldfogel J, et al. Spanking and child development across the first decade of life. Pediatrics 2013;132:e1118–25. [OpenUrl][1][Abstract/FREE Full Text][2] The use of corporal punishment, despite repeated caution from health professionals and developmental researchers, persists as a widespread parenting strategy in the USA.1 As Mackenzie and colleagues note, the prevalence of spanking by American parents appears surprising when one considers the litany of studies linking corporal punishment with deleterious outcomes across the life course. Mackenzie and colleagues extended this body of research by examining … [1]: {openurl}? query=rft.jtitle%253DPediatrics%26rft_id%253Dinfo%253Adoi%252F10.1542%252Fpeds.2013-1227%26rft_id%253Dinfo%253Apmid%252F24144718%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink? linkType=ABST&journalCode=pediatrics&resid=132/5/e1118&atom=%2Febnurs%2F17%2F4%2F114.atom
Illness perception and quality of life in patients with breast cancer.

e19567 Background: In the last decade the interest to know the modulating factors of the quality of life in oncological patients has grown. Previous researches suggest that the illness perception is closely related with the quality of life of these patients. The objective of our study is to assess the dimensions of illness perception that explain the quality of life of patients. METHODS Seventy five consecutive patients were evaluated by the Brief Illness Perception Questionnaire and the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-30) at the admission interview of the mental health service of a specialized institute in oncological illness.A logistic regression analysis was calculated to assess the illness perception dimensions that explain the variance in the quality of life. Variables that showed significant association were included in the logistic regression model (Wald statistics). RESULTS Higher scores of Identity subscale were associated with lower probabilities to have a good quality of life (p=.027), role functioning (p=.042) and cognitive functioning (p=.004) and higher probabilities to have fatigue (p=.027). Additionally higher scores of Emotional Response subscale were associated with lower probabilities to have a good social functioning (p=.018) and finances (p=.009). Higher scores of Consequences subscale were associated with higher probabilities to have nausea and vomiting (p=.039). Higher scores of Preoccupation subscale were associated with higher probabilities to have diarrhea (p=.039). Finally, higher scores of Control of illness subscale were associated with higher probabilities to have dysnea (p=.048) Conclusions: The knowledge about the relation between the illness perception dimensions and the quality of life will allow the development of specific strategies that improve the daily functioning of the cancer patients, increasing the coping ability of the illness.
Obesity, insulin resistance, and nocturnal systolic blood pressure.

An increasing prevalence of obesity is observed in all age and ethnicity groups and is increasingly being recognized as a serious health problem in children and adolescents.1–4 Obesity is associated with a number of metabolic abnormalities, as well as increased risk for cardiovascular disease (CVD). 3,4 In this issue of Hypertension , Lurbe et al5 reported a relationship between insulin resistance, determined by the homeostatic model assessment technique, and nocturnal elevations of systolic blood pressure and heart rate in a large cohort of overweight and obese European children and adolescents. This relationship was present even after adjustment for age, sex, and height. Furthermore, waist circumference was strongly associated with insulin resistance, and both waist circumference and insulin resistance were associated with elevated nocturnal, but not daytime, blood pressures. These are important observations despite some limitations as to the methodology that the investigators used. One limitation of this report is the fact that sleep was not well documented, which limited the ability to strongly relate the nocturnal blood pressures and heart rate to …
The Influence of Different External Cooling Methods on Thermoregulatory Responses Before and After Intense Intermittent Exercise in the Heat

The purpose of this study was to determine the effect of different cooling methods on thermoregulation before and after intermittent anaerobic exercise in the heat (38° C). On separate days, 10 men completed 4 conditions consisting of 2 sets of six 30-second sprints (with 30 seconds of rest) at 125% of maximal aerobic power with each set of sprints followed by a cooling procedure. The 4 conditions were the following: passive cooling at room temperature (22° C; PRC), fan cooling (4.0 m·s−1, 22° C; FAC), fan cooling with water spraying (50 ml·min−1; FWC), and a noncooling passive recovery in the heat chamber (38° C; PCC). Each set of 6 sprints was followed by a 12-minute cooling period; after the second 12-minute period, cooling continued until esophageal temperature (Tes) was reduced by 1.0° C. Tes and mean skin temperatures (Tsk) were taken before and during exercise and during all cooling phases. Cooling rates (mean ± SEM) after the second set of sprints (based on Tes) were greater (p < 0.05) in PRC (0.043 ± 0.007) than in the other conditions (FWC = 0.027° ± 0.005°, FAC = 0.03° ± 0.004°, and PCC = 0.021° ± 0.003° C per minute). Overall decreases in heat content, however, were greater in the FWC (-332.2 ± 27.8) and FAC (-129.9 ± 14.7 kJ) conditions compared with the PRC condition (29.0 ± 14.9 kJ). The time required to lower Tes by 1.0° C with PRC (22.8 ± 1.8) was less than with FAC (30.4 ± 2.7 minutes). Finally, the rate of increase in Tes during the second set of sprints was less in the FAC and FWC conditions (0.15° ± 0.01° and 0.11° ± 0.01° C per minute) compared with the PCC and PRC conditions (0.19° ± 0.01° and 0.18° ± 0.01° C per minute), suggesting differences in pre-exercise cooling. Based on cooling rates and the time required to lower Tes by 1.0° C, PRC was the most effective method of cooling. The conclusion is different, however, when taking into account changes in heat content since the FAC and FWC conditions were more effective in dissipating heat and in preventing heat gain during the second set of sprints
Computational Logic - Essays in Honor of Alan Robinson

By reading, you can know the knowledge and things more, not only about what you get from people to people. Book will be more trusted. As this computational logic essays in honor of alan robinson, it will really give you the good idea to be successful. It is not only for you to be success in certain life you can be successful in everything. The success can be started by knowing the basic knowledge and do actions.
Lowered national cesarean section rates after a concerted action

To evaluate national cesarean section (CS) rates and other obstetric indicators after a concerted action to reduce CS rates was undertaken in Portugal from 2010 onwards. This action was based on the transmission of information and training of healthcare professionals, together with the inclusion of CS rates as a criterion for hospital funding.
Fibrosis of Collagen I and Remodeling of Connexin 43 in Atrial Myocardium of Patients with Atrial Fibrillation

Background: Fibrosis in atrial myocardium is a common phenomenon for patients with atrial fibrillation (AF). Remodeling of connexins was found accompanying with AF. The aim of the study is to investigate whether it is by causing the remodeling of connexin 43 (Cx43) that the fibrosis of atrial muscle plays an important role during the initiation and maintenance of AF. Methods: Samples of right atrial appendage were taken from 24 patients with rheumatic valvular disease during surgery. Fibrosis and remodeling of Cx43 was examined by microscopy and ultramicroscopy technique and analyzed by image analyzer. The collagen volume fraction of type I (CVF-I) and the volume fraction of Cx43 (Cx43VF) were studied between AF and sinus rhythm (SR) groups. Results: (1) Microscopic examination demonstrated that CVF-I significantly increased and Cx43VF decreased in patients with AF compared to those with SR. (2) The CVF-I was negatively correlated with the Cx43VF. Conclusion: The results suggest that fibrosis and remodeling of Cx43 are involved in the pathophysiologic mechanism of human AF. Fibrosis of atrial muscle may play an important role in the process of AF by means of interfering with remodeling of connexins.
Development of an LC-MS/MS method for studying migration characteristics of acetaldehyde in polyethylene terephthalate (PET)-packed mineral water

During storage, acetaldehyde migration from polyethylene terephthalate (PET) bottles can affect the quality of mineral water even in the low µg l−1 range negatively, as it features a fruity or plastic-like off-flavour. For a sensitive and fast analysis of acetaldehyde in mineral water, a new analysis method of 2,4-dinitrophenylhydrazine (DNPH) derivatisation followed by HPLC-electrospray tandem mass spectrometry (ESI-MS/MS) was developed. Acetaldehyde was directly derivatised in the mineral water sample avoiding extraction and/or pre-concentration steps and then analysed by reversed-phase HPLC-ESI-MS/MS using multiple reaction monitoring mode (MRM). Along with method development, the optimum molar excess of DNPH in contrast to acetaldehyde was studied for the mineral water matrix, because no specific and robust data were yet available for this critical parameter. Best results were obtained by using a calibration via the derivatisation reaction. Without any analyte enrichment or extraction, an LOD of 0.5 µg l−1 and an LOQ of 1.9 µg l−1 were achieved. Using the developed method, mineral water samples packed in PET bottles from Germany were analysed and the correlation between the acetaldehyde concentration and other characteristics of the samples was evaluated illustrating the applicability of the method. Besides a relationship between bottle size and CO2 content of the mineral water and acetaldehyde migration, a correlation with acetaldehyde migration and the material composition of the bottle, e.g. recycled PET, was noted. Investigating the light influence on the acetaldehyde migration with a newly developed, reproducible light exposure setup, a significant increase of the acetaldehyde concentration in carbonated mineral water samples was observed. Graphical Abstract
Peste des Petits Ruminants Vaccine (Nigerian Strain 75/1) Confers Protection for at Least 3 Years in Sheep and Goats

The present study reports the duration of immunity and protective efficacy of Peste des Petits Ruminants (PPR) vaccine (Nigerian strain 75/1) in sheep and goats. A total of 105 sheep and goats were divided into three groups A, B and C. Group A received normal recommended dose (1.0 ml) of PPR vaccine, group B received half dose (0.5 ml) of PPR vaccine and group C was kept as unvacci- nated control group in contact with vaccinated animals. The post vaccination dynamics of antibo- dies against PPR virus was studied. It was found that significant antibody titres persisted for 3 years post vaccination in sheep and goats vaccinated with either full dose or half dose of PPR vac- cine. The challenge protection studies were carried out in experimental animals at 24 and 36 month post vaccination. The vaccinates withstood challenge and were found completely resistant clinically and virologically to virulent PPR virus for 24 and 36 months post vaccination. The un- vaccinated control animals developed typical clinical signs of PPR and the challenged virus was detected in ocular, nasal and oral secretions of these animals. This study demonstrated that a sin- gle immunization with PPR vaccine conferred solid protection in sheep and goats for 3 years.
Hybrid water pump system for hilly agricultural site

Water is a basic necessity of life. Plant need water to ensure their continuity. Hybrid water pump system flow the water from lake assisted by sun light for its operation via solar panels. The battery is connected in order to operate the pump during the night or cloudy day conditions. The system work by itself due to simple physics concept together with the development of electronic intelligent controller which consists of pressure and flow rate sensor. Pump motor will only work initially (start setup), then the watering system will continue to flow water from lake to farming plot based on siphon concept, so no continuous electricity required. If the water flow is slow, then the pump will be powered up and act as a booster to increase the water flow through a pipeline. Plus, the system is built as a portable device to make it easy to move or use for any circumstances that might happen. Overall, hybrid water pump system is the best-proposed solution for the present energy crisis for Luimewah issue.
Safety and efficacy of a salmonella gallinarum ΔcobSΔcbiA strain with potential to prevent chicken infections by salmonella gallinarum and salmonella enteritidis

New vaccine design techniques have allowed the development of effective vaccine strains against Salmonella infections inwhich the risks of reversion to the wild type and virulence is null. The mutant strain Salmonella Gallinarum ΔcobSΔcbiA was previously shown to be avirulent in chickens. In this study, this strain was tested as a vaccine against Salmonella Gallinarum (SG) and S. Enteritidis (SE) infections, and its protection levels, safety and possible risks of reversion to virulence after vaccination of layers were evaluated. Birds were vaccinated at five days of age or at five and 25 days of age. At 45 days of age, brown and white layers were challenged with SG and SE wild strains, respectively. Two assays to test the possibility of reversion to virulence were performed. Five successive bacterial passages in brown layers were carried out in the first assay. In the second assay, brown layers received a ten-fold concentrated inoculum of the SGΔcobSΔcbiA strain and were evaluated for clinical signs and mortality. In both experiments, no birds that received the inoculation of the attenuated strain died. Additionally, the use of the mutant strain as a vaccine provided good protection levels against both challenge strains.
High performance liquid chromatography analysis of anthocyanins in bilberries (Vaccinium myrtillus L.), blueberries (Vaccinium corymbosum L.), and corresponding juices.

UNLABELLED In the present study the anthocyanin content of commercially available bilberry juices and fresh fruits were quantified by using 15 authentic anthocyanin standards via high performance liquid chromatography with an ultra-violet detector (HPLC-UV/VIS). Delphinidin-3-O-glucopyranoside, delphinidin-3-O-galactopyranoside, and cyanidin-3-O-arabinopyranoside were the major anthocyanins found in juices, nectar, and fresh bilberries. In contrast, fresh blueberries had higher concentrations of malvidin-3-O-arabinopyranoside and petunidin-3-O-galactopyranoside. Up to 438 mg anthocyanins per 100 g fresh weight (2762 mg/100 g dry weight (DW)) were detected in blueberries from various sources, whereas bilberries contained a maximum of 1017 mg anthocyanins per 100 g fresh weight (7465 mg/100 g DW). Commercially available bilberry and blueberry juices (n= 9) as well as nectars (n= 4) were also analyzed. Anthocyanin concentrations of juices (1610 mg/L to 5963 mg/L) and nectar from bilberries (656 mg/L to 1529 mg/L) were higher than those of blueberry juices (417 mg/L) and nectar (258 mg/L to 386 mg/L). We conclude that using several authentic anthocyanin references to quantify anthocyanin contents indicated them to be up to 53% and 64% higher in fresh bilberries and blueberries, respectively, than previously reported using cyanidin-3-O-glucoside. This study has also demonstrated that commercially available juices produced from bilberries contain much higher anthocyanin concentrations than those from blueberries. PRACTICAL APPLICATION We have investigated the contents of a special class of antioxidants, namely anthocyanins in blueberry and billberry fruits and juices commercially available in Germany. To achieve reliable data we have used authentic standards for the first time. We think that our results are important in the field of nutritional intake of this important class of polyphenols and fruit juice companies get a closer insight in the occurrence of these antioxidants in market samples to be used in food composition databases and for nutritional survey.
INFLUENCE OF FORMULATION PARAMETERS ON DISSOLUTION RATE ENHANCEMENT OF PIROXICAM USING LIQUISOLID TECHNIQUE

ABSTRACT Objective: This study revealed formulation of a liquisolid system of poorly soluble piroxicam to enhance its dissolution rate. To formulate a liquisolid system loaded with piroxicam, solubility study was carried out in various non-volatile liquids. Methods: In 1 ml of polyethylene glycol (PEG) 600, 100 mg piroxicam was added and stirred with gentle heating. To the above liquid medication, 1 g microcrystalline cellulose (MCC) 102 (as MCC has given better results), 1 g Syloid 244 FP, 2 g PEG 4000, 500 mg aerosil 200, and 0.255 g sodium starch glycolate (SSG) (5%) were added and mixed properly. The blend was compressed and subjected for quality control parameters. Results: Among all the non-volatile liquids evaluated, piroxicam was most soluble in PEG 600. Using this as liquid medication, several liquisolid compacts were prepared by varying the ratios of MCC PH 102 as carrier and Syloid 244FP as coating material and evaluated for precompression studies. To further accelerate the release of drug, various additives were added in the formulation. Among them, PEG 4000 has shown better flow as well as compression properties. Hence, the final formulation (LS-16B) was prepared using a combination of MCC PH 102, Syloid 244 FP, PEG 4000 and SSG as superdisintegrant. The dissolution studies revealed that about 92.18% drug got released from liquisolid compacts in 120 minutes, whereas only 68.16% release was observed for pure piroxicam. X-ray diffraction and scanning electron microscopy images revealed the successful formation of liquisolid system. Conclusion: It was concluded that dissolution rate of poorly soluble piroxicam could be enhanced using liquisolid technique. Keywords: Piroxicam, Polyethylene glycol 600, Microcrystalline cellulose PH 102, Syloid 244 FP, Polyethylene glycol 4000.
Weight loss in Huntington disease increases with higher CAG repeat number

Objective: Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded number of CAG repeats in the huntingtin gene. A hallmark of HD is unintended weight loss, the cause of which is unknown. In order to elucidate the underlying mechanisms of weight loss in HD, we studied its relation to other disease characteristics including motor, cognitive, and behavioral disturbances and CAG repeat number. Methods: In 517 patients with early stage HD, we applied mixed-effects model analyses to correlate weight changes over 3 years to CAG repeat number and various components of the Unified Huntington’s Disease Rating Scale (UHDRS). We also assessed the relation between CAG repeat number and body weight and caloric intake in the R6/2 mouse model of HD. Results: In patients with HD, mean body mass index decreased with −0.15 units per year (p < 0.001). However, no single UHDRS component, including motor, cognitive, and behavioral scores, was independently associated with the rate of weight loss. Patients with HD with a higher CAG repeat number had a faster rate of weight loss. Similarly, R6/2 mice with a larger CAG repeat length had a lower body weight, whereas caloric intake increased with larger CAG repeat length. Conclusions: Weight loss in Huntington disease (HD) is directly linked to CAG repeat length and is likely to result from a hypermetabolic state. Other signs and symptoms of HD are unlikely to contribute to weight loss in early disease stages. Elucidation of the responsible mechanisms could lead to effective energy-based therapeutics.
Evaluation of geological hazards for landuse planning in Nabq protectorate, southeastern Sinai using GIS techniques.

Nabq protectorate is one of wonderful natural places in Egypt. It is characterized by diversity of bio-lives such as mangrove forests, coral colonies, wild life plants and migratory birds. Ongoing growth of tourism industries at Sharm El Sheikh northward into the Nabq protectorate causes severe hazards on its natural resources. The aim of the present study is to assess the present geo-environmental hazards in the Nabq protectorate. Assessment includes the analysis of satellite images, topographical, geological and other ancillary geological data using GIS technology. GIS data analyses indicate that the area is under threat from some of geo-hazards. Rough topography and mass wasting with high probability of flash flooding threaten different constructions in this area. The mobilization of coastal sand dunes, wave action and tidal currents are natural impacts on Nabq ecosystems, where moved dunes leave clay soils that are removed in some places by tropical storms increasing sea water turbidity that threaten the corals and other living organisms in the tidal flat region. The seismic activity hazard in the study area is usually active on lineaments extending parallel to the trend of the Gulf of Aqaba-Dead Sea transform fault where the Nabq protectorate occupies its southern segment. Unwise planning activities destroy the natural environmental resources in Nabq area by construction of new resorts on mangrove forests, coral colonies and raised beaches. Hazard assessment identifies land suitability and land use maps that are clearly exhibit models of traditional dams and buffer strips on coastal zone and highways as well as around the Bedouin communities which are worked on tourism and fishing. These maps are urgent in need of an assessment and rehabilitation program to mitigate geo-hazard.