Miracle-dz/UniFAR-FTUs huggingface dataset:
PENGARUH PENGETAHUAN KEUANGAN, SIKAP KEUANGAN, DAN KEPRIBADIAN TERHADAP PERILAKU MANAJEMEN KEUANGAN PADA PELAKU UMKM SENTRA KERAJINAN BATIK KABUPATEN BANTUL

Penelitian ini bertujuan untuk mengetahui (1) pengaruh Pengetahuan Keuangan terhadap Perilaku Manajemen Keuangan pada pelaku UMKM Sentra Kerajinan Batik Kab.Bantul, (2) pengaruh Sikap Keuangan terhadap Perilaku Manajemen Keuangan pada Pelaku UMKM Sentra Kerajinan Batik Kab.Bantul, (3) pengaruh Kepribadian terhadap Perilaku Manajemen Keuangan pada Pelaku UMKM Sentra Kerajinan Batik Kab.Bantul, (4) dan pengaruh Pengetahuan Keuangan, Sikap Keuangan, dan Kepribadian terhadap Perilaku Manajemen Keuangan pada Pelaku UMKM Sentra Kerajinan Batik Kab.Bantul. Subjek penelitian ini adalah seluruh pemilik UMKM Sentra Kerajinan Batik Kab.Bantul Sebanyak 37 UMKM. Uji prasyarat analisis meliputi uji linearitas, uji multikolinearitas dan uji heteroskedastisitas. Teknik analisis data yang digunakan adalah analisis regresi linier sederhana dan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa (1) terdapat pengaruh positif Pengetahuan Keuangan terhadap Perilaku Manajemen Keuangan pada pelaku UMKM Sentra Kerajinan Batik Kab.Bantul, (2) terdapat pengaruh positif Sikap Keuangan terhadap Perilaku Manajemen Keuangan pada pelaku UMKM Sentra Kerajinan Batik Kab.Bantul, (3) terdapat pengaruh positif Kepribadian terhadap Perilaku Manajemen Keuangan pada pelaku UMKM Sentra Kerajinan Batik Kab.Bantul, (4) terdapat pengaruh positif Pengetahuan Keuangan, Sikap Keuangan, dan Kepribadian terhadap Perilaku Manajemen Keuangan pada pelaku UMKM Sentra Kerajinan Batik Kab.Bantul. Kata Kunci: Pengetahuan Keuangan, Sikap Keuangan, Kepribadian, Perilaku Manajemen Keuangan
Telomerase Activity Links to Regenerative Capacity of Hepatocytes.

H are the main source of liver regeneration after injury. It has been shown that hepatocytes are a highly heterogeneous population with distinct functions. Whether there are specific hepatocyte subpopulations that are more regenerative remain controversial, and recent studies have identified discrete cell populations thatmaintain liver mass in homeostasis or after injury. Lin and colleagues have now used a transgenic mouse system to label hepatocytes with high telomerase expression (TERT) and showed that this population is the main cellular source for newly generated hepatocytes during homeostasis and injury. Telomerase is crucial in regulating the length of telomeres, which are repeating DNA sequences at the end of chromosomes to prevent chromosome attrition during cell divisions. Telomerase activity and length have been linked to the ability of stem cell in regenerating tissues, tumorigenesis, and aging. It is intriguing that a subset of hepatocyte population, around 3% to 5% in a homeostatic liver, are important for “healthy regeneration” and that ablation of these cells triggers pathophysiology seen in liver fibrosis and cirrhosis. Lin et al report that approximately 3% to 5% of hepatocytes are TERT in the adult mouse liver during homeostasis, and this population is distributed throughout the liver, but preferentially located at the periportal and the midlobular regions. TERT hepatocytes progressively repopulated the liver during liver homeostasis regardless of their location. The TERT population had a genetic profile which was more aligned to proliferation and self-renewal than metabolic function compared with other hepatocyte populations. This observation was confirmed by clonal analysis studies in which the authors labeled single cells in vivo and traced the fate of the cells over 6months. They showed that the TERT population
Impact of Above-Average Proanabolic Nutrients Is Overridden by High Protein and Energy Intake in the Muscle-Tendon Unit Characteristics of Middle- to Older-Aged Adults

Abstract Background The impact, within a single cohort, of independent modulators of skeletal muscle quality, including age, adiposity and obesity, habitual nutritional intake, and physical activity (PA), is unclear. Objective We examined the bivariate associations between age, adiposity, habitual nutritional intake, and PA against 11 key intrinsic muscle-tendon unit (MTU) characteristics to identify the strongest predictors. We also compared overall profile differences between MTU categories with the use of z scores shown in radar graphs. Methods Fifty untrained independently living men (n = 15) and women (n = 35) aged 43–80 y (mean ± SD: 64 ±9 y) were categorized by adiposity [men: normal adiposity (NA) <28%, high adiposity (HA) ≥28%; women: NA <40%, HA ≥40%] and body mass index [BMI (in kg/m2); normal: 18 to <25; overweight: ≥25 to <30; and obese: ≥30]. Group differences were examined by body composition assessed with the use of dual-energy X-ray absorptiometry, habitual nutritional intake through a 3-d food diary, PA (work, leisure, sport) using the Baecke questionnaire, 14 serum cytokine concentrations using multiplex luminometry, and 11 MTU characteristics of the gastrocnemius medialis using a combination of isokinetic dynamometry, electromyography, and ultrasonography. Results Interestingly, classification by BMI highlighted differences between normal and obese individuals in 6 of 11 MTU characteristics (P < 0.001 to P = 0.043). No significant differences were reported in serum cytokine concentrations between adiposity and BMI classifications. BMI predicted 8 of 11 (r = 0.62–0.31, P < 0.001 to P = 0.032), daily energy intake predicted 7 of 11 (r = 0.45–0.34, P = 0.002–0.036), age predicted 5 of 11 (r = −0.49–0.32, P < 0.001 to P = 0.032), work-based PA predicted 5 of 11 (r = 0.43–0.32, P = 0.003–0.048), and adiposity predicted 4 of 11 (r = 0.51–0.33, P < 0.001 to P = 0.022) MTU characteristics. Mathematical z scores and radar graphs showed how endocrine and dietary profiles, but not PA, differed between the top and bottom ∼20% of muscle unit size and specific force. Conclusions Given the number of factors associated with MTU, education should be targeted to both adequate food quantity and quality (especially protein intake) and increasing habitual moderate to vigorous PA while decreasing sedentary behavior. Specific endocrine variables are also proposed as key pharmaceutical targets.
Gastropods alien to South Africa cause severe environmental harm in their global alien ranges across habitats

Abstract Alien gastropods have caused extensive harm to biodiversity and socioeconomic systems like agriculture and horticulture worldwide. For conservation and management purposes, information on impacts needs to be easily interpretable and comparable, and the factors that determine impacts understood. This study aimed to assess gastropods alien to South Africa to compare impact severity between species and understand how they vary between habitats and mechanisms. Furthermore, we explore the relationship between environmental and socioeconomic impacts, and both impact measures with life‐history traits. We used the Environmental Impact Classification for Alien Taxa (EICAT) and Socio‐Economic Impact Classification for Alien Taxa (SEICAT) to assess impacts of 34 gastropods alien to South Africa including evidence of impact from their entire alien range. We tested for correlations between environmental and socioeconomic impacts per species, and with fecundity and native latitude range using Kendall's tau tests. Kruskal–Wallis tests were used to compare impact magnitude among mechanisms and habitats, respectively. This study presents the first application of EICAT and SEICAT for invertebrates. There was no correlation between environmental impacts and socioeconomic impacts. Habitats did not differ regarding the severity of impacts recorded, but impacts via disease transmission were lower than other mechanisms. Neither fecundity nor native range latitude was correlated with impact magnitude. Despite gastropods being agricultural and horticultural pests globally, resilience of socioeconomic systems makes high impacts uncommon. Environmental systems may be vulnerable to gastropod impacts across habitats, having experienced multiple local extinctions of wetland island snail fauna. South Africa stands out as the only continental country that follows this trend. The knowledge gained on severity and nature of gastropod impacts is useful in risk assessment, which can aid conservation management. To make impact assessments more realistic, we suggest alternative ways of reporting impacts classified under EICAT and SEICAT.
MiR‐218 regulated cardiomyocyte differentiation and migration in mouse embryonic stem cells by targeting PDGFRα

MicroRNAs (miRNAs) have been identified as key players in cardiogenesis and heart pathophysiological processes. However, many miRNAs are still not recognized for their roles in cardiomyocytes differentiation. In this study, we evaluated the effects of microRNA‐218 (miR‐218) in cardiomyocyte differentiation of the mouse embryonic stem cells (ESCs) in vitro. The percentage of the beating embryoid bodies (EBs) in miR‐218 mimic‐treated cells was reduced to 32% compared with miR‐218 mimic negative control (56%) on day 5 + 3. The amplitude of the intracellular Ca2+ transients in the cardiomyocytes derived from ESCs was reduced upon miR‐218 overexpression, followed by the decreased calcium‐related proteins and cell junction proteins expressions. Besides, miR‐218 expression in ESCs was related to the directional spreading ability of EBs during differentiation. The increased expression of miR‐218 could promote the migration of ESCs in vitro, while the decreased expression of miR‐218 could inhibit the migration by the transwell experiment. Meanwhile, miR‐218 could regulate cell migration–related proteins Cdc42 and Rac1. Platelet‐derived growth factor receptor α (PDGFRα) was further confirmed to be a direct target of miR‐218 both physically and functionally by dual‐luciferase reporter assay. Our data further described that overexpression of PDGFRα rescued the miR‐218‐mediated inhibition of cardiomyocyte differentiation and restored the miR‐218‐mediated promotion of cell migration. In conclusion, miR‐218 was demonstrated to exert an inhibitory function and promoted cell migration via targeting PDGFRα during cardiomyocyte differentiation from ESCs. The current study revealed the role of miR‐218 and may provide an important hint for cardiomyocyte differentiation of ESCs and induced pluripotent stem cells.
Microstructural Characterization of Carbon Nanotubes (CNTs)-Reinforced Nickel Matrix Nanocomposites

Abstract This research focuses on the microstructural characterization of nickel matrix composites reinforced by carbon nanotubes (CNTs). The nanocomposites were produced by a conventional powder metallurgy process and the dispersion of CNTs and mixture with nickel powders was performed in a single step by ultrasonication. Microstructural characterization of Ni–CNT nanocomposites was performed by scanning and transmission electron microscopy, electron backscattered diffraction, high-resolution transmission electron microscopy, selected area electron diffraction, and fast Fourier transform analyses. This characterization revealed CNTs embedded in the nickel grains and mainly presented as clusters at the grain boundaries. CNTs hinder recrystallization during sintering, and dislocation cells and subgrains form as a result of the recovery process.
Recent Advances in Liquid Biopsy in Patients With Castration Resistant Prostate Cancer

Management of localized and advanced prostate cancer benefits from several therapeutic options with a surprising improvement in terms of clinical outcome. The selection of patients more likely to benefit from a specific approach still remains a key issue as well as the early identification of patients with aggressive disease which could benefit from a more aggressive treatment strategy. The lack of reliable bio-marker in castration resistant setting able to monitor response to treatment and early inform about tumor progression is an emerging issue. Accordingly, circulating DNA and circulating tumor cells appears a promising and attractive approach despite to date practical applications of these techniques are few and not validated. The aim of this review of the literature is to explore current knowledge on liquid biopsy in prostate cancer focusing on possible future applications.
Analysis of the cancer genome atlas data to determine the correlation between PROX1 and TERT in hepatocellular carcinoma

Dear Editor, We read with great interest the article by Kim et al. regarding the role of prospero homeobox protein 1 (PROX1) and telomerase reverse transcriptase (TERT) in hepatocellular carcinoma (HCC); their study reported that PROX1 expression mediated TERT activity differently in accordance with the status of viral infection in HCC. Interestingly, TERT and PROX1 mRNA expression were positively correlated in non-B
On Variational Methods for Motion Compensated Inpainting

We develop in this paper a generic Bayesian framework for the joint estimation of motion and recovery of missing data in a damaged video sequence. Using standard maximum a posteriori to variational formulation rationale, we derive generic minimum energy formulations for the estimation of a reconstructed sequence as well as motion recovery. We instantiate these energy formulations and from their Euler-Lagrange Equations, we propose a full multiresolution algorithms in order to compute good local minimizers for our energies and discuss their numerical implementations, focusing on the missing data recovery part, i.e. inpainting. Experimental results for synthetic as well as real sequences are presented. Image sequences and extra material is available at this http URL
Bovine serum albumin nanoparticles improve the antitumour activity of curcumin in a murine melanoma model

Abstract Curcumin is a natural compound presenting important antitumour activity. However, due to its low aqueous solubility, instability at physiological pH, and low oral bioavailability, its clinical use is limited. Bovine serum albumin (BSA) nanoparticles have been used as drug carriers to improve the drug properties. In this work, curcumin-loaded BSA nanoparticles were developed and the in vitro cytotoxicity over murine melanoma cells and the in vivo antitumour activity in a murine melanoma model were assessed. Nanoparticles presented 150 nm, polydispersity index of 0.16, negative zeta potential, and 45% of curcumin encapsulation efficiency. Curcumin release from nanoparticles was slow and diffusion dependent. In the cytotoxicity assay, free curcumin was more efficient than curcumin-loaded nanoparticles, probably due to the prolonged curcumin release from nanoparticles. However, in a murine melanoma model, curcumin-loaded nanoparticles presented higher antitumour efficiency than free curcumin. BSA nanoparticles are efficient curcumin carriers that may have relevant applications in melanoma treatment.
Goji Berry Modulates Gut Microbiota and Alleviates Colitis in IL‐10‐Deficient Mice

SCOPE This study examines the beneficial effects of Goji berry against spontaneous colitis and its prebiotic role in IL-10-deficient mice. METHODS IL-10-deficient mice are assigned to a standard rodent diet (control) or a control diet supplemented with Goji (1% of dry feed weight) for 10 weeks, at which point colonic tissues and fecal contents are collected. RESULTS Goji supplementation decreases colonic pathobiological scores and mRNA expression of Il17a and Tgfb1, while it enhances Muc1 expression and fecal IgA content. Illumina MiSeq sequencing reveals that Goji supplementation increases Actinobacteria phylum, resulting in a bloom of Bifidobacteria in gut microbiota. Additionally, dietary Goji promotes butyrate-producing bacteria including Lachnospiraceae-Ruminococcaceae family and Roseburia spp. under Clostridium cluster XIVa. Furthermore, butyrate-producers Clostridium leptum and its dominant constituent Fecalibacterium prazusnitzii are markedly increased in the Goji group. Moreover, the gene-encoding butyryl-coenzyme A CoA transferase, a key enzyme responsible for butyrate synthesis in butyrate-producing bacteria, is increased sixfold in the fecal samples of Goji group associated with increased fecal butyrate content. CONCLUSION Data collectively show that dietary Goji results in the blooming of Bifidobacteria and butyrate-producing bacteria. These bacteria may cross-feed each other, conferring preventative effects against colitis in IL-10-deficient mice.
Association of High Levels of Spot Urine Protein with High Blood Pressure, Mean Arterial Pressure and Pulse Pressure with the Development of Diabetic Chronic Kidney Dysfunction or Failure among Diabetic Patients. Statistical Regression Modeling to Predict Diabetic Proteinuria

Introduction: In research elevated Blood Pressure (BP) has been demonstrated to be a risk for the development of nephropathy and chronic renal disease (CKD) Or Diabetic Kidney Disease (DKD) among diabetics. However, no study has find correlation for the spot urine protein (UPr) excretion with elevated BP, Pulse Pressure (PP) and mean arterial pressure MAP). This technique was invented in the current study. Methods: 10,270 were recruited for more than 12 years. Demographically, 43%, 38%, and 16% showed hypertension, nephropathy and chronic renal disease, respectively. UPr demonstrated significant correlations with systolic BP (SBP) and diastolic BP (DPB), MAP and PP (p < 0.0001 for all). SBP, DBP, PP and MAP, UPr were observed to be higher among the groups with nephroaphty and CKD/DKD with highly significant p-values (all p < 0.05). With logistic regression, odds ratio of hypertension (HTN) with nephropathy was observed to be 2.99 (95% CI 2.44 to 3.7; p < 0.0001); and odds ratio of HTN with CKD/DK was 7.1 (95% CI 4.3 to 11.84; p<0.0001), indicating that HTN significantly contributes to the development of nephropathy and CKD/DKD in diabetics. Results: Invented regression models for the excretion of UPr from the kidney with elevated SBP, DBP, MAP and PP were highly significant (p < 0.0001 for all); UPr = -138.6 + [1.347 × SBP] ; UPr = -93.4 + [1.62 × DBP] ; UPr = -149.5 + [1.922 × MAP] ; UPr = -41.23 +[1.541 × PP]. Conclusion: Current study is the first one to introduce this technique. These invented new equations can be used by physicians to estimate protein excretion in urine at bedside and outpatients departments for monitoring proteinuria and CKD/DKD.
The association between mentoring and training outcomes in junior doctors in medicine: an observational study

Objective To determine quantitatively if a positive association exists between the mentoring of junior doctors and better training outcomes in postgraduate medical training within the UK. Design Observational study. Participants 117 trainees from the East of England Deanery (non-mentored group) and the recently established Royal College of Physicians (RCP) Mentoring scheme (mentored group) who were core medical trainees (CMTs) between 2015 and 2017 completed an online survey. Trainees who received mentoring at the start of higher specialty training, incomplete responses and trainees who were a part of both the East of England deanery and RCP Mentoring scheme were excluded leaving 85 trainees in the non-mentored arm and 25 trainees in the mentored arm. Responses from a total of 110 trainees were analysed. Main outcome measures Pass rates of the various components of the Membership of the Royal College of Physicians (MRCP) (UK) examination (MRCP Part 1, MRCP Part 2 Written and MRCP Part 2 PACES), pass rates at the Annual Review of Competency Progression (ARCP), trainee involvement in significant events, clinical incidents or complaints and trainee feedback on career progression and confidence. Results Mentored trainees reported higher pass rates of the MRCP Part 1 exam versus non-mentored trainees (84.0% vs 42.4%, p<0.01). Mentored international medical graduates (IMGs) reported higher pass rates than non-mentored IMGs in the MRCP Part 2 Written exam (71.4% vs 24.0%, p<0.05). ARCP pass rates in mentored trainees were observed to be higher than non-mentored trainees (95.8% vs 69.9%, p<0.05). Rates of involvement in significant events, clinical incidents and complaints in both groups did not show any statistical difference. Mentored trainees reported higher confidence and career progression. Conclusions A positive association is observed between the mentoring of CMTs and better training outcomes. Further studies are needed to investigate the causative effects of mentoring in postgraduate medical training within the UK.
Does supportive supervision enhance community health worker motivation? A mixed-methods study in four African countries

Abstract Supportive supervision is an important element of community health worker (CHW) programmes and is believed to improve CHW motivation and performance. A group supervision intervention, which included training and mentorship of supervisors, was implemented in Ethiopia, Kenya, Malawi and Mozambique. In three of the countries, this was combined with individual and/or peer supervision. A mixed-methods implementation study was conducted to assess the effect of the supervision intervention on CHWs’ perceptions of supervision and CHW motivation-related outcomes. In total, 153 in-depth interviews were conducted with CHWs, their supervisors and managers. In addition, questionnaires assessing perceived supervision and motivation-related outcomes (organizational and community commitment, job satisfaction and conscientiousness) were administered to a total of 278 CHWs pre- and post-intervention, and again after 1 year. Interview transcripts were thematically analysed using a coding framework. Changes in perceived supervision and motivation-related outcomes were assessed using Friedman’s ANOVA and post hoc Wilcoxon signed-rank tests. Interview participants reported that the supervision intervention improved CHW motivation. In contrast, the quantitative survey found no significant changes for measures of perceived supervision and inconsistent changes in motivation-related outcomes. With regard to the process of supervision, the problem-solving focus, the sense of joint responsibilities and team work, cross-learning and skill sharing, as well as the facilitating and coaching role of the supervisor, were valued. The empowerment and participation of supervisees in decision making also emerged in the analysis, albeit to a lesser extent. Although qualitative and quantitative findings differed, which could be related to the slightly different focus of methods used and a ‘ceiling effect’ limiting the detection of observable differences from the survey, the study suggests that there is potential for integrating supportive group supervision models in CHW programmes. A combination of group with individual or peer supervision, preferably accompanied with methods that assess CHW performance and corresponding feedback systems, could yield improved motivation and performance.
Augmented‐reality robot‐assisted radical prostatectomy using hyper‐accuracy three‐dimensional reconstruction (HA3D™) technology: a radiological and pathological study

To assess the use of hyper‐accuracy three‐dimensional (HA3D™; MEDICS, Moncalieri, Turin, Italy) reconstruction based on multiparametric magnetic resonance imaging (mpMRI) and superimposed imaging during augmented‐reality robot‐assisted radical prostatectomy (AR‐RARP).