Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical and Mental Health Among Cancer Survivors

The physical and mental health of cancer patients needs to be addressed not only during active treatment but also throughout the continuum of survivorship care. This commentary provides an overview of issues pertinent to cancer survivors, with an emphasis on mental health issues and recommendations for annual clinical screening and monitoring using recently published guidelines from the American Society of Clinical Oncology.
Is worsening multiple organ failure the cause of death in patients with severe sepsis?*

Objectives:Although the mortality of severe sepsis is easily quantified, the actual cause and timing of death from severe sepsis are less defined. We used the INDEPTH (International Integrated Database for the Evaluation of Severe Sepsis and Drotrecogin alfa activated) database to investigate the reported cause of death in patients with severe sepsis. Design:Retrospective database analysis. Patients:Data from 4459 patients with severe sepsis (drotrecogin alfa activated, n = 3228; placebo, n = 1231) included in five clinical trials conducted in tertiary care institutions in 28 countries. Measurements and Main Results:We examined the cause of death and the pattern of Sequential Organ Failure Assessment scores near the time of death. We also evaluated the time course of biomarker levels at this late stage. A total of 1201 (27.0%) patients died during the 28-day study period. The main causes of death were as follows: sepsis-associated multiple organ failure (43.1%), refractory septic shock (22.6%), and respiratory failure (13.0%). There were no significant differences in the distributions of cause of death between drotrecogin alfa activated and placebo patients, so that all patients were combined for analysis. The mean cardiovascular Sequential Organ Failure Assessment score increased from 2.4, 4 days before death, to 2.9, 1 day before death, and the mean respiratory Sequential Organ Failure Assessment score increased from 2.6, 4 days before death, to 2.9, 1 day before death. The increase in these individual Sequential Organ Failure Assessment scores was more prominent in patients who died early (day 0–5). Protein C levels decreased and interleukin-6 levels increased in the days before death. Conclusion:Patients with severe sepsis typically die of multiple organ failure, refractory shock, or respiratory failure. Persistent, more than worsening, organ failure is the more common pattern before death.
Evaluation of DNA Based Techniques for the Diagnosis of Human Vaginal Trichomoniasis in North Indian Population

Introduction: Human trichomoniasis due to Trichomonas vaginalis is a curable sexually transmitted infection. It may lead to symptomatic vaginitis or asymptomatic carrier state. The symptoms and signs mimic other pathologies and conventional techniques of diagnosis have its own limitations. Therefore, the present study aimed to evaluate a newly established in-house PCR based assay on pfoB gene and compared it with conventional wet smear examination method and 18S rRNA gene based PCR technique for the diagnosis of T. vaginalis in symptomatic and asymptomatic subjects. Materials and Methods: Four hundred women in age group 20-57 years attending the Obstetrics and Gynecology out Patients Department (OPD) of Nehru Hospital attached to Post Graduate Institute of Medical education and Research (PGIMER) Chandigarh, India were included in the study. Based on the symptoms and signs, 344 (86%) women were categorized as symptomatic and 56 (14%) as asymptomatic. Vaginal swabs collected from all the women were processed by three techniques including wet smear, 18S rRNA and the pfoB gene based PCR techniques for the detection of T. vaginalis . Results: The main presenting symptom in majority of symptomatic patients was vaginal discharge. The highest numbers of T. vaginalis positive patients were found in the sexually active age group of 20 to 40 years. The amplifications of pfoB and 18S rRNA gene by PCR revealed significantly higher positive cases (20.7% and 18.6%, respectively) than the wet smear (6.6%) method. The diagnostic efficacy and kappa value estimated by the three techniques were 86.8-100% and 35.5-66%, respectively. Conclusions: The combined application of any two of the three techniques used in the present study may be useful for the diagnosis of T. vaginalis infection in symptomatic and asymptomatic subjects. This information may help clinicians to make a timely and accurate diagnosis.
A Highly Sensitive and Low-Cost Sagnac Loop Based Pressure Sensor

A pressure sensor based on Sagnac loop using polarization-maintaining photonic crystal fiber operating at 850 nm with much extended measuring range is experimentally demonstrated. We propose a frequency and phase detection technique to enable much extended measurement range comparing with previously proposed schemes. The scheme gives a linear relationship between phase and pressure variation. Experimental results agree well with theoretical predications. The study also shows that operating at 850 nm improves pressure sensitivity by about three times compared with sensors operating at 1550 nm. It enables the use of low-cost and high-speed charge-coupled device interrogator for measurement.
CENTRAL CARDIOVASCULAR EFFECTS OF NARCOTIC ANALGESICS AND ENKEPHALINS IN RATS

1 The cardiovascular effects of morphine, fentanyl, [d‐Ala2]‐met‐enkephalinamide were analyzed after intracisternal injection in anaesthetized rats. Pao2 was measured as an index of respiratory function. 2 At low doses in spontaneously breathing rats, morphine, fentanyl and [d‐Ala2]‐met‐enkephalinamide induced a pressor response with slight tachycardia and no significant change in Pao2. 3 The pressor response appeared to be due to activation of opiate receptors and mediated through the sympathetic nervous system. 4 High doses of morphine and [d‐Ala2]‐met‐enkephalinamide induced a biphasic effect with a secondary hypotension associated with bradycardia in spontaneously breathing rats. A marked reduction in Pao2 was found during the depressor phase. 5 High doses of [d‐Ala2]‐met‐enkephalinamide produced only a pressor response in artificially‐ventilated rats with no signs of secondary hypotension. 6 Our data support the idea that morphinomimetic agents are centrally pressor at low doses in the rat. The respiratory depression observed with high doses may be the cause of hypotension.
Comparative study of different fingerprint compression schemes

The aim of this paper is to discuss the important features of wavelet transform and other existing methods in compression of fingerprints. Image quality is measured objectively using peak signal-to-noise ratio (PSNR). A comparative study among discrete cosine transform based joint photographic experts group (JPEG) standard, embedded zerotree wavelet (EZW) scheme and JPEG2000 is done. The study shows that EZW and JPEG2000 results in compression ratio 40:1 which is much higher than the existing FBI wavelet/scalar quantization (WSQ) standard that offers best compression at 26:1. Our results helps application developers to choose a good wavelet compression system for their applications.
Short Communication Molecular characterization of medically important viruses of the genus Orthobunyavirus

We have characterized the full-length S segment RNA sequences of five human pathogens of the virus family Bunyaviridae, genus Orthobunyavirus. S segment sequences of Fort Sherman, Shokwe and Xingu viruses of the Bunyamwera serogroup, as well as those of Bwamba and Pongola viruses of the Bwamba serogroup, are described. S segment sequences of Bwamba and Pongola viruses represent the first nucleotide sequences characterized for viruses of the Bwamba serogroup. The described molecular and phylogenetic analyses of these and other selected viruses of the genus Orthobunyavirus reveal that a close sequence similarity is shared between the African Bwamba and the predominantly North American and European California serogroups of the genus Orthobunyavirus.
Workplace measurements by the U.S. Occupational Safety and Health Administration since 1979: Descriptive analysis and potential uses for exposure assessment.

This letter summarizes modifications to the results presented in Lavoué et al. (2012): Lavoué, J., Burstyn, I. ,Friesen, M. (2012) Workplace Measurements by the US Occupational Safety and Health Administration since1979: Descriptive Analysis and Potential Uses for Exposure Assessment. Annals of occupational hygiene57(1):77–97. Although several results were altered, the conclusions were not affected by the changes.
Deactivation Improvement of Advanced CMOS Devices Using a Flood BC PLAD Process

Flood buried-contact (FBC) plasma doping (PLAD) is a promising scheme to improve both pMOS and nMOS device performance with a significant cost reduction. Deactivation characteristics of CMOS devices doped by an FBC implant using an ultra-low energy (ULE) BF3 PLAD process is extensively evaluated from inline [front end of line (FEOL)] to final [back end of line (BEOL)] to investigate the impact of the backend thermal processing. nMOS devices show more serious deactivation than pMOS devices from FEOL to BEOL. However, both pMOS and nMOS devices obtained further improvements at BEOL processing. The mechanism of nMOS device performance improvement can be attributed to the Schottky barrier height lowering effect and carrier deactivation improvement, as well as other effects including silicide stability improvement and mechanical stress. It is observed that the deactivation of nMOS device can be improved by an ULE BF3 PLAD process which can be interpreted by less dopant loss and F passivation on the interface between the source/drain and the dielectric spacer. Another important observation is that the deactivation improvement is more profound for the small-size devices. Deactivation characteristics of CMOS devices are consistent with our recent deactivation mechanism studies of blanket wafers (electrical-assisted diffusion mechanism), and provide further evidence for this mechanism.
Discover gene specific local co-regulations from time-course gene expression data

Discovering gene co-regulatory relationships is one of most important research in DNA microarray data analysis. The problem of gene specific co-regulation discovery is to, for a particular gene of interest called target gene, identify the condition subsets where strong gene co-regulations of the target gene are observed and its co-regulated genes in these condition subsets. The co-regulations are local in the sense that they occur in some subsets of full experimental conditions. The study on this problem can contribute to better understanding and characterizing the target gene during the biological activity involved. In this paper, we propose an innovative method for finding gene specific co-regulations using genetic algorithm GA. A sliding window is used to delimit the allowed length of conditions in which gene co-regulations occur and an ad hoc GA, called the progressive GA, is performed in each window position to find those condition subsets having high fitness. It is called progressive because the initial population for the GA in a window position inherits the top-ranked individuals obtained in its preceding window position, enabling the GA to achieve a better accuracy than the non-progressive algorithm. kNN Lookup Table is utilized to substantially speed up fitness evaluation in the GA. Experimental results with a real-life gene expression data demonstrate the efficiency and effectiveness of our technique in discovering gene specific co-regulations.
Resistance exercise training restores bone mineral density in renal transplant recipients.

Background The kidneys are complex organs of human body sustain a number of vital and important functions. These organs need to be replaced in some subjects due to various diseases. Bone mineral density (BMD) of the subjects with kidney transplantation reduced as a result of poor mobility and use of especial drugs. Due to lack of information regarding the influences of weight training exercise on BMD of long bone, this research was done. Method 24 subjects with history of kidney transplantation were recruited in this study. They were divided into two groups who received weight training exercise and control group. The BMD of femur and lumbar spine was measured by use of dual energy X-Ray absorptiometry in both groups. The difference between BMD was evaluated by use of two sample T test. Result The mean values of BMD of femur were 0.679±0.09 g/cm2 and 0.689±0.09 before and after exercise in this first group. In contrast it was 0.643±0.11 before follow-up and 0.641±0.11 g/cm2 after follow-up in the control group. There was no difference in BMD of lumbar spine after exercise. Conclusion The result of this research study showed that BMD of long bone improved follow exercise. Therefore, it was concluded that weight training exercise can be used for the subjects with kidney transplantation.
Wideband end-fire phased array for WiGig applications

A 1×4 phased array antenna in package is presented at 60 GHz frequency band. End-fire elements are double side dipoles which provide a near omni-directional beam in H-plane. In E-plane, the phased array facilitates ±45° beam steering which improves the spatial coverage. The achieved end-fire gain is 9.1 dBi and both impedance and gain bandwidths cover all WiGig channels. The wide bandwidth, high coverage, and high gain of the phased array make it a desirable candidate for multi-gigabit wireless communication.
Postpartum depression help-seeking barriers and maternal treatment preferences: a qualitative systematic review.

BACKGROUND Despite the well-documented risk factors and health consequences of postpartum depression, it often remains undetected and untreated. No study has comprehensively examined postpartum depression help-seeking barriers, and very few studies have specifically examined the acceptability of postpartum depression treatment approaches. The objective of this study was to examine systematically the literature to identify postpartum depression help-seeking barriers and maternal treatment preferences. METHODS Medline, CINAHL, and EMBASE databases were searched using specific key words, and published peer-reviewed articles from 1966 to 2005 were scanned for inclusion criteria. RESULTS Of the 40 articles included in this qualitative systematic review, most studies focused on women's experiences of postpartum depression where help seeking emerged as a theme. A common help-seeking barrier was women's inability to disclose their feelings, which was often reinforced by family members and health professionals' reluctance to respond to the mothers' emotional and practical needs. The lack of knowledge about postpartum depression or the acceptance of myths was a significant help-seeking barrier and rendered mothers unable to recognize the symptoms of depression. Significant health service barriers were identified. Women preferred to have "talking therapies" with someone who was nonjudgmental rather than receive pharmacological interventions. CONCLUSIONS These results suggest that women did not proactively seek help, and the barriers involved both maternal and health professional factors. Common themes related to specific treatment preferences emerged from women of diverse cultural backgrounds. The clinical implications outlined in this review will assist health professionals in addressing these barriers and in developing preventive and treatment interventions that are in accord with maternal preferences.
Application of Systems Principles to Resolving Ethical Dilemmas in Medicine

Ms W, a 23-year-old woman, was hospitalized in the intensive care unit (ICU) of a large urban teaching hospital with a diagnosis of metastatic sarcoma that was considered terminal. Two years earlier, Ms W had had a sarcoma surgically removed from her left thigh. She was feeling well until four weeks before this hospitalization, when she developed night sweats and difficulty breathing. At the time her symptoms appeared, Ms W was engaged to be married and was preparing to graduate from college. She had no history of mental illness, and had a high-functioning and intact family. Application of Systems Principles to Resolving Ethical Dilemmas in Medicine
Machine learning for embedded devices software analysis via hardware platform emulation

Nowadays commercial-off-the-shelf (COTS) embedded devices are widely used in many security-critical systems like nuclear stations and traffic control systems. Most of these devices has proprietary hardware and software (frequently called firmware) with little documentation available. Another common feature is the use of “binary blob” firmware, where hardware specific and high level layers can't be easily separated and, therefore are forced to be analyzed together. All these facts make firmware analysis quite a challenging task. In this paper, we'll suggest an approach for the firmware analysis with poorly documented hardware platform emulation. The advantages of this approach are almost full control under firmware state, achieving easy to scale fuzzing and manual bug hunting facilitation. For the purpose of successful realization, an identification of communication between hardware components (e.g. communication between main SoC and Bluetooth SoC) should be done. To address this issue, we suggest the use of machine learning, which, because of its nature, enables construction of algorithms that can learn from and make predictions on data.
Genomic islands 1 and 2 carry multiple antibiotic resistance genes in Pseudomonas aeruginosa ST235, ST253, ST111 and ST175 and are globally dispersed

to that of the widely spread Tn 1548 -bearing plasmid pMDR-ZJ06 (Rep3 family), with the gene cassette aac(3 0 )-II being replaced by aacA4 and catB8 (accession no. CP001938). The K. pneumoniae strain belongs to MLST sequence type 307 (ST307) and harboured a 20 kb plasmid (IncF) that was notinvestigatedfurther. This study demonstrates that pan-aminoglycoside resistance may be acquired by P. aeruginosa following the transfer of Tn 1548 on Pseudomonas -speciﬁc plasmids such as pOZ176. Whether the Tn 1548 module was transmitted in vivo from K. pneumoniae or A. baumannii is unknown. However, the observation that a patient may be colonized with several phylogenetically different ArmA-producing bacteria highlights the diffusion potentials of Tn 1548 among Gram-negative species and reinfor-ces the need to screen for 16S rRNA methylases not only in Acinetobacter and Enterobacteriaceae species, but also in P. aeruginosa. A high resistance to arbekacin (MIC . 256 mg/L) may serve as an indicator of methylase pro-ductionpriortotheuseofmolecularbiologymethods.
Simplified Authoring of 3 D Haptic Content for the World Wide Web

As haptic technology becomes more developed, the potential applications for three-dimensional haptic content online become more and more numerous. However, the proliferation of such content has been restricted by the fact that it requires considerable effort to create. In this paper, we present a system for allowing this content to be more easily authored and displayed. In our system, threedimensional content created with a simple modeling language is displayed haptically by the internet browser. Thus, three-dimensional haptic scenes for the web can be written in this simple language, allowing the webpage author to circumvent the more complex scripting and/or programming which is currently necessary. Such a system should facilitate the creation of three-dimensional haptic content for the web.
Hybrid rectangular printed strip monopole dielectric resonator antenna

This paper presents the design and simulation of hybrid rectangular printed strip monopole dielectric resonator antenna (HRPSMDRA) for ultra wideband communication systems. The designed HRPSMDRA is analyzed and optimized using power modeling software CST Microwave Studio ®. The designed HRPSMDRA assembly consists of hybridizing an annular hexagon dielectric resonator (DR) with a rectangular printed strip monopole antenna. The combination effect of three radiators produces multiple resonances frequency and provides 120% ultra wideband (UWB) of 10dB return loss impedance bandwidth centered at 11.8 GHz, making this antenna suitable for UWB applications. The designed HRPSMDRA provide an average gain of 4.82 dBi with the far-field radiation characteristics appears to be satisfied within the operating bandwidth.
Novel RING Finger Proteins, Air1p and Air2p, Interact with Hmt1p and Inhibit the Arginine Methylation of Npl3p*

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are involved in the mRNA processing and export and are post-translationally modified by methylation at arginine residues in their arginine-glycine-rich (RGG) domains. We screened the factors that can interact with the RGG domain of Npl3p only in the presence of Hmt1p with the two-hybrid system in Saccharomyces cerevisiae. An isolated clone, YIL079, encodes a novel RING finger protein that was not directly bound to Npl3p but associated with the N terminus of Hmt1p. Thus, we designated the gene product Air1p (arginine methyltransferase-interactingRING finger protein). Air1p inhibited the Hmt1p-mediated methylation of Npl3p in vitro. Overexpression of Air1p repressed the Hmt1p-dependent growth of cells. Since homology searches indicate that the YDL175 gene product has significant identity (45%) with Air1p, we designated the geneAIR2. Air2p also has a RING finger domain and was bound to Hmt1p. Although single disruption of either gene gave no effect on the cell growth, cells lacking Air1p and Air2p grew at an extremely slow rate with accumulated poly(A)+ RNA in the nucleus. Thus, Air1p and Air2p may affect mRNA transport by regulating the arginine methylation state of heterogeneous nuclear ribonucleoproteins.
TGFA/TAQ I Polymorphism in Nonsyndromic Cleft Lip and Palate Patients from Rio Grande Do Sul, Brazil

Objective: To test the TGFA/Taq I polymorphism in the development of nonsyndromic cleft lip and palate. Design And Setting: The research was based on a case-control study, including nonsyndromic cleft lip and palate patients (140 individuals) and a control sample of unaffected individuals (142) to ascertain the absence or presence of genic mutation at the TGFA locus. Interventions: The DNA of carriers of nonsyndromic cleft lip with or without cleft palate was obtained by buccal swab, and the DNA of the control group was extracted from peripheral blood leucocytes. TGFA/Taq I polymorphism was determined genetically by polymerase chain reaction using specific primers and fragment digestion with Taq I restriction enzyme. Results: No significant association was detected when patients and controls were compared with the genotype for TGFA/Taq I polymorphism. Conclusion: Mutations in TGFA gene have no association with nonsyndromic cleft lip and palate in the sample from Rio Grande do Sul. Therefore, based on this study, it is not possible to determine the role played by TGFA in the expression of cleft lip and palate.
Two-Incision Technique for Treatment of Complex Proximal Humerus Fractures

The treatment of complex proximal humerus fractures that involve displacement of the greater tuberosity remains challenging. Good functional outcomes and decreased pain are possible with open reduction and internal fixation. Keys to a successful outcome include preservation of blood supply through decreased soft-tissue stripping, restoration of normal anatomic relationships (particularly the greater tuberosity), and stable internal fixation that allows early range of motion. To attain these goals, we advocate fixation with a fixed-angle locking proximal humerus plate using a 2-incision approach. A deltopectoral incision is used to expose the humeral shaft and head while the greater tuberosity is visualized by using a lateral incision. The fracture fragments are reduced and the plate is secured by working through these 2 incisions.