Miracle-dz/UniFAR-FTUs huggingface dataset:
Saccadic movements using eye-tracking technology in individuals with autism spectrum disorders: pilot study.

OBJECTIVE To verify differences in the visual scanning strategies between pervasive developmental disorders (PDD) and controls when they are observing social and non-social pictures. METHOD PDD group (PDDG) comprised by 10 non-retarded subjects (age from 4 to 41) and age-matched control group (CG). Nine social pictures with human beings (including two pictures of cat mask), and 3 nonsocial pictures of objects were presented for 5 seconds. Saccadic movements and fixation were recorded with equipment EyeGaze (LC Technologies Inc.). RESULTS PDDG (mean=292.73, SE=67.62) presented longer duration of saccadic movements for social pictures compared to CG (mean=136.06, SE=14.01) (p=0.04). The CG showed a higher number of fixations in the picture 7 (a women using a cat mask, with the eyes erased) (CG: mean=3.40; PDDG: mean=1.80; p=0.007). CONCLUSION The results suggest differences in strategies that PDD explore human picture. Moreover, these strategies seem not to be affected by the lack of expected part of the face (the eyes).
European Organization for Research and Treatment of Cancer (EORTC)

The European Organization for Research and Treatment of Cancer (EORTC) is a pan-European nonprofit cancer research organization that develops conducts, coordinates, and stimulates high-quality translational and clinical research to improve the standards of cancer care. Founded in 1962, the EORTC has since developed into a vast network of cancer research expertise and infrastructure with more than 2500 scientists and clinicians who collaborate across over 200 affiliated institutions and academic centers in 30 countries. Cancer clinical trial research carried out by the EORTC has contributed to improvements in the quality of life and survival of cancer patients, extended the definition of standards for cancer patient care, advanced the practice of organ preservation as well as minimal and nonmutilating cancer surgery, and established diagnostic and treatment guidelines that aid clinicians in the treatment decision-making process. The EORTC has also contributed to the advancement of cancer research through its educational programs and activities for scientists, clinicians, young researchers, patients, and the public. The EORTC has undertaken organizational and strategic initiatives throughout the years and continues to adopt novel strategic approaches to meet the challenges of the rapidly changing cancer research environment. Additional breakthroughs in the prevention, diagnosis, and treatment of cancer in the current era of molecular biology will be accomplished primarily through translational research projects, efficient drug development, and the conduct of translational research-guided large prospective randomized multicenter clinical trials. The EORTC has been a leader in cancer research for over 45 years and will continue to devote its energy and expertise to high-quality clinical cancer research throughout the twenty-first century to improve the standards of cancer care, advance the scientific understanding of cancer as a disease, and address pivotal strategic therapeutic questions. Keywords: cancer research; clinical trials; translational; standard of care
The sense of coherence and risk of injuries: role of alcohol consumption and occupation

Study objective: To test the hypothesis that individuals with a strong sense of coherence (SOC) have a decreased incidence of external cause injuries and to study the role of alcohol consumption and occupational category in that association. Design: Participants of the Helsinki Heart Study were followed up for injuries for eight years through the national hospital discharge register and cause of death statistics. Cox proportional hazards models were used to calculate the relative risks. Setting: The Helsinki Heart Study, a clinical trial to prevent coronary heart disease. Participants: 4405 Finnish middle-aged employed men. Main results: The SOC was inversely associated with the risk of injuries, with a significant 25% lower incidence in the highest tertile of SOC (7.6 per 1000 person-years) compared with the lowest (10.2 per 1000 person-years). The association remained significant if adjusted for age, but not if adjusted additionally for alcohol consumption or occupation. When considered jointly with occupational category, the injury risk showed a decreasing trend (p = 0.02) with increasing SOC among blue collar but not among white collar workers. The use of alcohol had a great impact on injury risk among those with weak SOC, with incidences of 7.7, 10.2, and 14.9 per 1000 person-years in the non/light, medium, and heavy categories of consumption (p for trend 0.01). No such trend was seen in other SOC tertiles. Conclusions: There was an effect of SOC on the incidence of injury especially among blue collar workers. A substantial part of the effect was mediated by alcohol consumption.
Isolated Fracture of the posterolateral tibial lip (Volkmann's triangle)

Purpose: to retrospectively evaluate the underlying pathomechanism of isolated fracture of the posterolateral tibial lip (Volkmann's triangle), and to demonstrate associated radiographic methods. Material and Methods: Retrospective analysis of 2500 ankle lesions showed an isolated fracture of the dorsal tibial lip in 25 cases. Distal tibial lesions of growing individuals were not considered. All patients were examined by radiography in internal oblique and lateral views. Results: Sixteen of 25 patients had had their accident during winter; 11 had slipped on ice or snow. All 25 patients showed a closed ankle lesion in the correct joint position with no clinical signs of instability. Evaluation of the standard images showed isolated fracture of the posterolateral tibial lip in 24 patients. the fracture was best recognized in the standard lateral view in 22 patients. in 2 patients the lateral stress projection demonstrated the fracture (20° internal rotation). in one case the fracture was only seen on axial CT images. Twenty-two patients with small wedge fragments were treated conservatively; 3 with a displaced and large fragment had surgical revision and stabilization. Sixteen cases were examined by conventional radiography at follow-up examination and 5 of these showed radiological signs of arthrosis. Conclusion: Plain conventional radiography is still necessary in the primary diagnosis of ankle joint lesions. the isolated fracture of the dorsal tibial margin is best seen in the standard lateral view. Indication for CT in routine diagnostics is limited to cases showing clinical evidence of ankle injury without roentgenological signs of a fracture in the standard images. Differential diagnoses include the pilon lesion and the Maison-neuve-type fracture.
Oncogenic MicroRNA-155 Down-regulates Tumor Suppressor CDC73 and Promotes Oral Squamous Cell Carcinoma Cell Proliferation

Background: Cause of the complete loss of CDC73 in a subset of parathyroid tumors remains to be elucidated in the absence of a second mutation and promoter methylation. Results: Oncogenic miR-155 causes down-regulation of tumor suppressor CDC73 in OSCC. Conclusion: miR-155 up-regulation adds yet another mechanism for CDC73 down-regulation in tumors. Significance: Targeting miR-155 adds novelty to OSCC therapeutics. The CDC73 gene is mutationally inactivated in hereditary and sporadic parathyroid tumors. It negatively regulates β-catenin, cyclin D1, and c-MYC. Down-regulation of CDC73 has been reported in breast, renal, and gastric carcinomas. However, the reports regarding the role of CDC73 in oral squamous cell carcinoma (OSCC) are lacking. In this study we show that CDC73 is down-regulated in a majority of OSCC samples. We further show that oncogenic microRNA-155 (miR-155) negatively regulates CDC73 expression. Our experiments show that the dramatic up-regulation of miR-155 is an exclusive mechanism for down-regulation of CDC73 in a panel of human cell lines and a subset of OSCC patient samples in the absence of loss of heterozygosity, mutations, and promoter methylation. Ectopic expression of miR-155 in HEK293 cells dramatically reduced CDC73 levels, enhanced cell viability, and decreased apoptosis. Conversely, the delivery of a miR-155 antagonist (antagomir-155) to KB cells overexpressing miR-155 resulted in increased CDC73 levels, decreased cell viability, increased apoptosis, and marked regression of xenografts in nude mice. Cotransfection of miR-155 with CDC73 in HEK293 cells abrogated its pro-oncogenic effect. Reduced cell proliferation and increased apoptosis of KB cells were dependent on the presence or absence of the 3′-UTR in CDC73. In summary, knockdown of CDC73 expression due to overexpression of miR-155 not only adds a novelty to the list of mechanisms responsible for its down-regulation in different tumors, but the restoration of CDC73 levels by the use of antagomir-155 may also have an important role in therapeutic intervention of cancers, including OSCC.
China-CEEC Cooperation: China’s Building of a New Type of International Relations

Abstract The article analyzes how the 16+1 Cooperation promotes the Chinese new type of international relations from four perspectives: firstly, the “16+1 Cooperation” insists on not rejecting third parties and promotes the idea of open and inclusive international cooperation; Secondly, the cooperation framework adheres to the principle of mutually-beneficial and win-win cooperation, and proposes to wisely handle differences and divergences; Thirdly, this framework never engages in zero-sum games, instead, it fully respects and closely watches the core interests and major concerns of the relevant parties; Fourthly, it is committed to creating a cooperative platform through consultation, to meet the interests of all. The article also makes an analysis of the challenges facing 16+1 Cooperation and gives some suggestions.
Hate Crime and the Legal Process: Options for Law Reform

The aim of this study was to assess the application of criminal laws and sentencing provisions for hate crime in England and Wales (Crime and Disorder Act 1998 (CDA), ss. 28- 32, and the Criminal Justice Act 2003 (CJA), ss. 145 and 146) in order to capture best practices and identify barriers to the implementation of these rules. The study was carried out over a 24-month period and used a multitude of sources, both secondary and primary, to answer a number of key questions that were first set out by the Law Commission’s 2014 report on hate crime law reform, as well as other questions set out as part of an EU cross jurisdictional project.
Telehomecare communication and self-care in chronic conditions: moving toward a shared understanding.

BACKGROUND Remote telemonitoring of patients' vital signs is a rapidly increasing practice. Although methods of communication in remote electronic monitoring differ from those in traditional home health care, the understanding shared by the nurse, patient, and family members remains the same: patients' self-care behaviors affect exacerbations of chronic health conditions. The purpose of this paper is to examine the relationship between communication and information integration into the daily lives of patients with chronic illnesses and offer best practice recommendations for telehomecare nurses (THN). METHODS The original study used the Social Relations Model to examine relationships within 43 triads composed of patients with chronic conditions, home helpers, and their nurse involved in telehomecare at three Veterans Health Administration sites. This secondary descriptive and correlational analysis compared 43 patients' and nine THNs' ratings of themselves and each other on communication (frequency, timeliness, and understanding) and the use of patients' daily telemonitored information. RESULTS There was almost no correlation between patients' perception of THNs' communication (frequency [r=0.05], timeliness [r=0.09], and understandability [r=0.03]) and patients' integration of information into daily health practices. However, significant correlations were found between the THNs' perception of patients' communication frequency and timeliness, and integration, (p=0.02; p<0.001) respectively. CONCLUSIONS This study suggests that frequent phone communication may lead the remote THN to believe patients are integrating blood pressure, weight, and other information into daily self-care behaviors, when in fact the patient reports that they are not. The influence of a halo effect on the THN may cloud an accurate perception of what is actually occurring. Remote communication may require more attention to THNs educating patients about shared understandings when using telemonitoring. Best practices for THN should include explicit goals and intentions for telemonitored home care with individualized instructions about how to use the information for self-care.
Evidence That the Age at Diagnosis of IDDM Is Genetically Determined

OBJECTIVE The aim of this study was to determine the impact of genetic or environmental factors on the age or time of onset of IDDM by studying pairs of twins and siblings concordant for the disease. RESEARCH DESIGN AND METHODS From 404 twin pairs referred to a diabetic twin study, we selected pairs concordant for IDDM: 1) 116 identical pairs with an index twin diagnosed diabetic under age 60 years and 2) 12 identical and 12 nonidentical matched twin pairs. From 972 families referred to a population-based diabetic family study, we selected sibling pairs with IDDM: 33 pairs with an index case diagnosed diabetic under age 21 years. Twin and sibling pairs were analyzed for intraclass correlations for age and time of diagnosis. RESULTS Of twins concordant for IDDM, the age at diagnosis correlated 1) in 116 identical pairs (R = 0.94; P < 0.000001) and 2) more closely in 12 identical twins (R = 0.96, P < 0.000001) than 12 nonidentical twins (R = 0.59, P = 0.046). Of 33 sibling pairs with IDDM, the age, but not the time, of diagnosis was correlated (R = 0.53, P = 0.0016). CONCLUSIONS Correlations within pairs of twins and siblings for age, not time, at diagnosis suggest that much of the variability of the age at diagnosis of IDDM is genetically determined.
A Robust Position and Force Control Strategy for 7-DOF Redundant Manipulators

This paper is concerned with robust position and contact force control for 7-DOF redundant robot arms. An outer-inner loop controller, called the augmented hybrid impedance control scheme is developed. A 6-DOF force/torque sensor is used to measure the interaction forces. These are fed back to the outer-loop controller that implements either a force or an impedance controller in each of the 6 DOF of the tool frame. The force controller is provided with a force set point, and desired inertia and damping are introduced in the force control loop to improve transient performance. The inner loop consists of a Cartesian-level potential difference controller, a redundancy resolution scheme at the acceleration level, and a joint-space inverse dynamics controller. Experimental results for two 7-DOF robot arms (redundant, dextrous, isotropically enhanced, seven-turning pair robot (REDIESTRO) and Mitsubishi PA10-7C) are given to illustrate the performance of the force control strategy. A successful application of the proposed scheme to a surface cleaning task is described using the REDIESTRO, while position and force tracking experiments are described for the Mitsubishi PA10-7C robot.
Compound heterozygosity of HLA‐DRB3 * 01:01 and HLA‐DRB4 * 01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia

BACKGROUND: Fetal neonatal alloimmune thrombocytopenia (FNAIT) is a life‐threatening bleeding disorder in the fetus or neonate caused by maternal alloantibodies directed against fetal platelet (PLT) antigens inherited from the father. The immune‐dominant antigen leading to severe FNAIT is the human PLT antigen (HPA)‐1, whose polymorphism constitutes an epitope for human leukocyte antigens (HLAs), usually DRB3*0101 leading to an immune response.
Dementia anxiety among older adult caregivers: an exploratory study of older adult caregivers in Canada

ABSTRACT Background: Although caring for individuals with dementia is known to result in increased burden and depression among caregivers, little research has investigated caregiver's anxiety or concern about eventually developing dementia themselves (i.e. dementia anxiety). Existing research reports mixed findings regarding variables (e.g. relationship to care recipient, sex, education) that predict dementia anxiety among caregivers and non-caregivers. Potential relationships among burden, depression and dementia anxiety have not been extensively examined. The present study explored caregiver and care recipient factors as predictors of dementia anxiety in older adult caregivers. Methods: A sample of 116 older adult caregivers answered demographic/background questions and completed a series of self-report measures assessing dementia anxiety, caregiver burden, depression, and the physical disability of the care recipient. Results: The majority of caregivers were female, Caucasian, and reported caring for a spouse. Analyses revealed that background variables were generally not related to dementia anxiety, while depression and caregiver burden were significantly associated. Using linear regression analysis, it was found that a diagnosis of dementia in the care recipient and caregiver depression were both significant predictors of caregiver dementia anxiety. Conclusion: Health care providers should be aware that dementia anxiety is associated with caring for individuals with dementia as well as with depression. Dementia anxiety may place additional strain on caregivers of individuals who have dementia and are suffering from depression and thus should be the focus of future research.
Identification and partial characterization of a parasite antigen in sera from humans infected with Wuchereria bancrofti.

The purpose of this study was to identify and characterize soluble parasite antigens present in sera from humans infected with the filarial nematode Wuchereria bancrofti. Affinity chromatography and immunoblot methods were used to demonstrate a 200,000 m.w. circulating parasite antigen in sera from infected humans which corresponded to an antigen released by adult W. bancrofti during in vitro culture. Two monoclonal antibodies were produced to this antigen by immunizing mice with antigens from Dirofilaria immitis, a filarial parasite that is closely related to W. bancrofti, and screening cell fusion supernatants by enzyme immunoassay and counterimmunoelectrophoresis inhibition. The antibodies bound to a single repeated epitope (not phosphorylcholine) that was resistant to heat, acid, and protease treatments but sensitive to periodate oxidation. Immunoperoxidase studies showed that the epitope was concentrated in the cuticle and reproductive organs in D. immitis, and it was released in relatively large amounts by adult female D. immitis in vitro. The epitope is also present in antigens of other species of filarial and nonfilarial nematodes, but on the basis of preliminary studies, its presence in human serum appears to be specific for W. bancrofti infection.
Comparison of dexmedetomidine–propofol vs. fentanyl–propofol for laryngeal mask insertion

Background and objectives There have been many studies to find the optimum anaesthetics to provide excellent conditions for laryngeal mask insertion. We compared the effects of dexmedetomidine administered before propofol, on laryngeal mask insertion with fentanyl combined with propofol. Methods In all, 52 patients, ASA I–II, scheduled to have minor urological procedures were randomized into two groups. Group F received 1 &mgr;g kg−1 fentanyl (in 10 mL normal saline) and Group D received 1 &mgr;g kg−1 dexmedetomidine (in 10 mL normal saline). We used 1.5 mg kg−1 propofol for induction and 50% N2O and 1.5% sevoflurane in oxygen for maintenance. We observed jaw mobility (1: fully relaxed; 2: mild resistance; 3: tight but opens; 4: closed), coughing or movement (1: none; 2: one or two coughs; 3: three or more coughs; 4: bucking/movement) and other events such as spontaneous ventilation, breath holding, expiratory stridor and lacrimation. In each category, scores <2 were acceptable for laryngeal mask insertion. Results More patients developed apnoea and their apnoea times were longer in Group F than Group D (P < 0.001). Respiratory rates increased in Group D (P < 0.001). Adverse events during laryngeal mask insertion were similar. The reductions in systolic and mean blood pressures were greater in Group F (systolic: P < 0.05, mean: P < 0.01). Emergence times were shorter in Group F than in Group D (P < 0.001). Conclusion Dexmedetomidine, when used before propofol induction provides successful laryngeal mask insertion comparable to fentanyl, while preserving respiratory functions more than fentanyl.
Blending group and practice site scores to increase the reliability of physician quality information.

OBJECTIVE To use an empirical Bayesian approach, blending practice, and group quality data with physician results to increase the accuracy of quality of care measures. DATA SOURCES Performance data on diabetes glycemic screening for 8,357 physicians collected from multiple payers as part of a statewide physician performance reporting initiative. STUDY DESIGN A variance components analysis assessed the strength of group, practice, and physician effects compared with random error. We derived formulas to describe reliability and measurement error variances and calculated the optimal blend of physician, practice, and group data. We constructed a simulation to show what various methods can achieve. The value of blending strategies was assessed by simulating a common pay-for-performance criterion-performance in the top 25 percent. We estimated the proportion of physicians whose true percentage would place them in the top 20 percent but who would not receive payment based on the observed success rate. PRINCIPAL FINDINGS Blending reduced the error rate from 29.7 to 22.7 percent. Simpler empirical Bayes estimates using shrinkage alone produced no gains over simple doctor percentages. CONCLUSIONS When good structural data about physician groups and practices exist, gains from blending can be substantial.