Miracle-dz/UniFAR-FTUs huggingface dataset:
Market Sentiment Helps Explain the Price of Bitcoin

A simple model that accurately explains the market price of Bitcoin (BTC) based on Metcalfe's law and market sentiment on social networks is presented. A previously proposed model has shown that the number of unique addresses and the estimated transaction value per address explain most of the variation of the BTC price. We demonstrate that the model’s accuracy can be further increased by introducing a market sentiment volume about BTC that is positively scored on Twitter and StockTwits.
Sleep estimates using microelectromechanical systems (MEMS).

Study Objectives: Although currently more affordable than polysomnography, actigraphic sleep estimates have disadvantages. Brand-specific differences in data reduction impede pooling of data in large-scale cohorts and may not fully exploit movement information. Sleep estimate reliability might improve by advanced analyses of three-axial, linear accelerometry data sampled at a high rate, which is now feasible using microelectrome-chanical systems (MEMS). However, it might take some time before these analyses become available. To provide ongoing studies with backward compatibility while already switching from actigraphy to MEMS accelerometry, we designed and validated a method to transform accelerometry data into the traditional actigraphic movement counts, thus allowing for the use of validated algorithms to estimate sleep parameters. Design: Simultaneous actigraphy and MEMS-accelerometry recording. Setting: Home, unrestrained. Participants: Fifteen healthy adults (23-36 y, 10 males, 5 females). Interventions: None. Measurements: Actigraphic movement counts/15-sec and 50-Hz digitized MEMS-accelerometry. Analyses: Passing-Bablok regression optimized transformation of MEMS-accelerometry signals to movement counts. Kappa statistics calculated agreement between individual epochs scored as wake or sleep. Bland-Altman plots evaluated reliability of common sleep variables both between and within actigraphs and MEMS-accelerometers. Results: Agreement between epochs was almost perfect at the low, medium, and high threshold (kappa = 0.87 ± 0.05, 0.85 ± 0.06, and 0.83 ± 0.07). Sleep parameter agreement was better between two MEMS-accelerometers or a MEMS-accelerometer and an actigraph than between two actigraphs. Conclusions: The algorithm allows for continuity of outcome parameters in ongoing actigraphy studies that consider switching to MEMS-accel-erometers. Its implementation makes backward compatibility feasible, while collecting raw data that, in time, could provide better sleep estimates and promote cross-study data pooling.
Correlation between Psychological Well-Being and Quality of Life among Traffic Police

Traffic police play a very significant role in controlling the traffic system especially in the metropolitan cities despite several limitations. Traffic police work tends to impose a high degree of stressful situations which can affect the physical health, mental health and quality of life of traffic police and it is the matter of concern. The objective of the present study is to study the relationship between psychological well-being and quality of life of traffic police. For the present research random sampling technique was adopted. 120 traffic police was selected for the study from Lucknow city. World Health Organization quality of life questionnaire (WHOQOL) was used to measure quality of life of traffic police and psychological well being scale developed by (Sisodia S.D. and Choudary P. 2012) was used to measure the psychological wellbeing of traffic police. Significant positive correlations was found between two variables is psychological well-being and quality of life. This indicated that with increase in psychological well-being, there is an increase in the quality of life in the entire sample.
Imbalance of Oxidative and Reductive Species Involved in Chromium(VI)-Induced Toxic Effects

Hexavalent chromium [Cr(VI)] is a common environmental pollutant which can be exposed via digestive tract, respiratory tract, and skin contact, and directly or indirectly cause adverse health effects in humans. Extensive research indicates that generation of reactive oxygen species (ROS) from the reduction of Cr(VI), an important characteristic of Cr(VI) metabolism, is the major mechanism underlying the toxic effects induced by Cr(VI) treatment, such as apoptosis, DNA damage, and carcinogenesis. ROS production is increased in a time-dependent and dose-dependent manner during the reduction of Cr(VI) by various biological systems. Meanwhile, positive regulation of antioxidative defenses also plays important roles in balancing ROS levels. This review summarizes the recent progress on the ROS and antioxidative system induced by Cr(VI) exposure. Some representative signaling cascades and molecules, including AP-1, NF-κB, p53, Nrf2, and Akt are discussed in depth with regard to their involvement in Cr(VI)-induced toxic effects.
An analysis of national research systems ( I ) : a composite indicator measuring scientific and technological research excellence

This paper first develops a framework for the analysis of national research systems, with particular focus on the excellence of scientific and technological research, a central topic for the current European research and innovation policy discourse. Next, after carefully considering measurement and data issues, it proposes a set of strong and weaker country-level indicators of research excellence, based on which a composite indicator of scientific and technological research excellence is proposed and tested for robustness and sensitivity. The research was conducted on behalf of DG RTD within the framework of the “Composites 4IU” project. As the Commission’s in-house science service, the Joint Research Centre’s mission is to provide EU policies with independent, evidence-based scientific and technical support throughout the whole policy cycle. Working in close cooperation with policy Directorates-General, the JRC addresses key societal challenges while stimulating innovation through developing new standards, methods and tools, and sharing and transferring its know-how to the Member States and international community. Key policy areas include: environment and climate change; energy and transport; agriculture and food security; health and consumer protection; information society and digital agenda; safety and security including nuclear; all supported through a cross-cutting and multi-disciplinary approach. LB -N A -2 6 0 9 3 EN -N
Design of an Extraction, Transform and Load Process for Calculation of Teamwork Indicators in Moodle

Assessment and measurement of teamwork still remains as one of the main challenges in computer-assisted and digital education. A large majority of virtual learning environments and learning management systems are mostly either student-centred or content-centred. Therefore, most of the database records are stored at an individual level. While this approach for log-based learning analytics of student data at individual level is highly valuable and adequate, it also makes it difficult for students, instructors and researchers to collect, analyze and visualize group data in team-based education methods. Measurement and characterization of the different components of teamwork are essential in order to get insight about whether the activities are being performed by teams effectively. This study refines previous proposals for measurement of teamwork indicators in online education –communication, coordination, cooperation and tracking, at both individual and team levels–, and proposes the design and implementation of extraction, transform and load processes to collect those indicators from Moodle, illustrating the execution of these processes with an example.
The Direct Costs of type 2 Diabetes Mellitus Outpatient care in the Ghanaian Public Health System: A Case of the Cape Coast Teaching Hospital

Background: Diabetes Mellitus (DM) is a growing epidermic with its parallel economic impact on the health system and society. The objective of this study was to estimate the direct medical and direct non-medical costs of type 2 diabetes outpatient care in a Ghanaian Public Health Care System. Methods: The study was conducted at the Cape Coast Teaching Hospital outpatient diabetes clinic from January, 2016 through May, 2016. A total of 204 randomly selected patients with diabetes attending the diabetes clinic were interviewed and their medical records data reviewed. Direct medical costs included expenses with anti-diabetic medications, diabetesrelated laboratory tests, blood glucose strips and consultations with healthcare professional’s. Direct non-medical costs included expenses with transportation, artificial sweeteners and herbal medicines. Results: The annual mean direct medical cost for outpatient care for a person with DM was 1,491.45 Ghana cedis (US$ 390.43) on oral anti-diabetics paid by the National Health Insurance Scheme, out of which medications accounted for the largest proportion of the direct medical cost (42.7%), followed by cost of glucose strips (16.6%). Also, on the average a person with diabetes spend out of pocket of 188.29 GHS (US$ 49.29) per year in private pharmacies for diabetes medications. Also longer duration of the disease was associated with increased cost and the mean annual direct medical cost was higher in females than males (US$ 362.98 vs $332.58). Having hypertension and dyslipidaemia as co-morbities added an additional cost of US$ 123.02 and $90.16 respectively on medications for treatment annually. The mean direct non-medical cost was GHS 110.93 (US$ 29.04), out of which transportation accounted for the largest proportion (52.3%). Conclusion:This study showed that outpatient diabetes management leads to elevated cost to the Ghanaian Public Health care System. Costs increased along with duration of disease and presence of co-morbities. There is the need to focus on primary prevention of diabetes, its co-morbidities and
The effect of a clinoptilolite based mineral adsorber on concentrations of immunoglobulin G in the serum of newborn calves fed different amounts of colostrum

The aim of the study was to investigate the influence of added natural mineral adsorber zeolite (clinoptilolite) to the colostrum on the degree of absorption of colostral IgG in 60 Holstein newborn calves fed different amounts of colostrum during the first two days of life. Calves were divided in four groups: 1) experimental group I received 0.75L of colostrum with 5g/L of clinoptilolite in 12h intervals (0.75+); 2) experimental group II received 1.5L of colostrum with 5g/L of zeolites in 12h intervals (1.5+); 3) control group I received 0.75L of colostrum in 12h intervals (0.75-); 4) control group II received 1.5L of colostrum in 12h intervals (1.5-). In blood sera from experimental group I, concentrations of IgG were 15.79±6.53 g/l; 21.81 ±9.29 g/L and 20.30±8.64 g/L respectively 6, 24 and 48 hours after birth. IgG concentrations in the sera of experimental group II were 22.21 ±8.79 35.20±8.43 and 30.51 ±9.86 respectively 6, 24 and 48 hours after birth. In the blood sera of the first control group concentrations of IgG were 9.89±4.97; 18.07±5.32 and 15.84±4.92 respectively 6, 24 and 48 hours after birth. IgG concentrations of the second control group were 14.53±7.19 25.39±11.57 and 22.88±8.63 respectively 6, 24 and 48 hours after birth. The statistical significance of the difference in mean IgG concentrations between experimental group I and the first control group was high after 6 (p<0.05) hours after birth. In this groups, the difference was not statistically significant 24 and 48 hours after birth. The statistical significance of the difference in levels of IgG between the experimental group II and the second control group was high after 6 (p<0.001), 24 (p<0.01) and 48 (p<0.05) hours. It can be seen that the absorption rate of colostral IgG in calves from the experimental groups I and II was approximately 40% higher than in the respective control groups. The mean concentrations of IgG in the colostrum samples used to feed the calves were almost equal during the observed period. Agarose-gel electrophoresis of serum proteins 48 hours after birth showed in the gamma electrophoretic zone a more intesively colored fraction for the treated animals compared to the analogous fraction on the electrophoresogram of serum proteins in the control group. Imunoglobulin G concentrations in the sera of calves who received 0.75 I of colostrum with clinoptilolite were almost equal to imunoglobulin G concentrations in the sera of calves who received 1.51 of colostrum at 6 hours after birth (this effect is present at 24 and 48 hours after birth). It can be seen that calves which received an insufficient amount of colostrum with clinoptilolite had the same concentrations of serum IgG compared to the calves which received the full ration of colostrum. The data from this investigation show that a concentration of 5 g/l of clinoptilolite based mineral adsorber in the colostrum leads to a significantly higher degree of absorption of colostral IgG in newborn calves.
Personality, sensation seeking and holiday preference

The objective of this study was to analyse the correlations between Personality (Neuroticism and Conscientiousness of the Five Factor Model, measured with the IPIP), Sensation Seeking (measured with the BSSS by Hoyle et al., 2002), and Holiday Preferences (as suggested by Eachus, 2004: Beach, Adventurous, Cultural, and Indulgent Holidays). The three scales were combined and set online. 226 subjects invited by email filled in the survey. The correlations between Sensations Seeking and the Holiday Preferences allowed suggesting descriptions of the four different types of tourists. Only N5 Immoderation, Conscientiousness, C1 Self-Efficacy, C4 Achievement-Striving, and C6 Cautiousness were significantly correlated with Holiday Preferences. Furthermore is was found, that even if the total Neuroticism score did not correlate with Sensation Seeking and its subscales, the N-facets N1 Anxiety, N4 Self-Consciousness, at least when controlled for age, and N5 Immoderation did ell correlate significantly. The fact that the correlations were positive for N1 and N4, and negative for N5 explains why earlier studies did not find significant correlations for the total dimension of Neuroticism. Conscientiousness correlated negative with Sensation Seeking, which was reflected mainly in its subscales Thrill and Adventure Seeking, Disinhibition, and Boredom Susceptibility. Only C1 Self-Efficacy did not correlate significant with Sensation Seeking. The Five Factor Model is criticized for its claim of independence of the Big Five, which is questioned by several findings of this study.
Megakaryocytes in chronic phase of chronic myeloid leukemia: A descriptive case series

Background: Megakaryocytic proliferation and functional alterations are frequently observed in various myeloproliferative neoplasms (MPN). An analysis of these alterations provides clue to the diagnosis of MPN such as essential thrombocythemia and myelofibrosis. We in our descriptive study have tried to evaluate and identify the morphological features of the megakaryocytes seen in chronic myeloid leukemia- chronic phase (CML-CP). Methods: Bone marrow aspirate and trephine biopsy from 31 newly diagnosed cases of CML-CP were evaluated for the morphological parameters including count, distribution, clustering, cytoplasmic granularity, nuclear lobes, micromegakaryocytes, fragmented nuclei, bare nuclei, and emperipolesis. All the cases were also evaluated for marrow reticulin fibrosis Result: Megakaryocytic count was increased in 58% of cases (18 out of 31), 67.7% had parasinusoidal distribution, 67.7% had no megakaryocytic clusters. Hypolobation of nuclei and presence of micromegakaryocytes were consistent findings in all the cases. The megakaryocyte count showed a positive correlation with the grade of marrow reticulin fibrosis and peripheral blood platelet count. Conclusion: Characteristic changes in megakaryocyte number, distribution and morphological features is seen in CML-CP and may help in differentiating it from other MPN’s.
Exposure and Cardiorespiratory Mortality – Estimating the Effects and Economic Losses in São Paulo , Brazil

Air pollution is an important health risk concern and an economic burden, notably on lowand middle-income countries. The aim of this study was to determine the mortality burden of cardiovascular and respiratory diseases, specifically, the relative risk due to air pollution and the economic valuation derived from life-years lost within the population of São Paulo, Brazil. This study was conducted using a retrospective Health Impact Assessment (HIA) approach via daily time series of cardiovascular and respiratory deaths for the population of São Paulo from 2000 to 2011. The effects of particulate matter smaller than 10 μm (PM10) were estimated with Poisson generalized additive models. The single-day lag effects of air pollutant exposure were estimated for 0–3-day lags. Therefore, we obtained the years of life lost (YLL) through the disability-adjusted life years (DALY) method to estimate the burden of disease due to air pollution in São Paulo. The value of a life year (VOLY) was then applied to convert the YLL component to economic loss. The results showed an association between PM10 and cardiovascular and respiratory mortality, lagging 3 days. The YLL totaled 231,691.8 years, meaning an overall economic loss of more than US$14.1 billion. In conclusion, knowledge regarding the costs of premature deaths related to air pollution can be used to improve public policy and to facilitate decision making in the context of scarce resources.
Clinical Implication of 18 F-FDG-PET in Diagnosing and Monitoring Disease Activity in a Case of Subclinical Stage of Giant Cell Arteritis

Giant cell arteritis (GCA) is a systemic vasculitis which typically occurs in persons over 50 years old. GCA is closely related to polymyalgia rheumatica (PMR). A temporal artery biopsy is the gold standard test for the diagnosis of GCA. Recently, there is increasing evidence for the role of F-fluorodeoxyglucose positron emission tomography (F-FDG-PET) in diagnosis of vasculitis. Here, we report on a case of a 67-year-old Korean male who was diagnosed with atypical GCA in subclinical stage concomitant with PMR by F-FDG-PET. After treatment, abnormal findings of F-FDG-PET were improved. (J Rheum Dis 2015;22:382-386)
Effect of Shadowing and Multipath Fading on the Area Spectral Efficiency of a Macro-Femto Heterogeneous Network for Cell-Edge Users

The traditional macro-only network is not effective especially when communication signal is required for users far away from the macrocell base station and located in the cell edge. The signal strength reaching these users is excessively attenuated due to fading and shadowing. The deployment of femtocells around the cell edge of this macrocell helps to reduce the effect of fading and shadowing thereby increasing the overall efficiency of the cellular network. This holds a great promise for adaptive space-based wireless sensor networks, formation-flying satellites and constellations. Keywords: Femtocells; Heterogeneous networks; Macrocells; Spectral Efficiency; Uplink
Cardiovascular Safety of Incretin-Based Drugs in Type Two Diabetes Mellitus Patients

Diabetes Mellitus (DM) is a chronic metabolic disease with complicated complex pathogenesis. Frequency of newly DM arises worldwide and associated with steadily increased morbidity and mortality due to DM-related complications. The incretin-based drugs are posed as remedies modulated effects of natural incretin hormones: GLP-1 (glucagon-like peptide 1), GIP (glucose-dependent insulinotropic peptide) and dipeptidyl peptidase enzyme 4 (DPP4). At the beginning of the era of the incretin-based therapy the treatment of T2DM with GLP-1 analogs and DPP-4 inhibitors was introduced. In fact, incretin-based drug exposure was associated with clinically significant cardiovascular protection. However, it is not known whether all GLP-1 analogs and DPP-4 inhibitors are similar in their capacities to improve cardiovascular outcomes or not that is required a continuous studies in this direction.
Numerical Modeling of Galactic Cosmic-Ray Proton and Helium Observed by AMS-02 during the Solar Maximum of Solar Cycle 24

Galactic cosmic rays (GCRs) are affected by solar modulation while they propagate through the heliosphere. The study of the time variation of GCR spectra observed at Earth can shed light on the underlying physical processes, specifically diffusion and particle drifts. Recently, the AMS-02 experiment measured with very high accuracy the time variation of the cosmic-ray proton and helium flux between 2011 May and 2017 May in the rigidity range from 1 to 60 GV. In this work, a comprehensive three-dimensional steady-state numerical model is used to solve Parker’s transport equation and reproduce the monthly proton fluxes observed by AMS-02. We find that the rigidity slope of the perpendicular mean free path above 4 GV remains constant, while below 4 GV, it increases during solar maximum. Assuming the same mean free paths for helium and protons, the models are able to reproduce the time behavior of the p/He ratio observed by AMS-02. The dependence of the diffusion tensor on the particle mass-to-charge ratio, A/Z, is found to be the main cause of the time dependence of p/He below 3 GV.
IMAGE-BASED DEFORMATION MONITORING OF STATICALLY AND DYNAMICALLY LOADED BEAMS

Structural health monitoring of civil infrastructure systems is an important procedure in terms of both safety and serviceability. Traditionally, large structures have been monitored using surveying techniques, while fine-scale monitoring of structural components has been done with instrumentation for civil engineering purposes. As a remote sensing technique, photogrammetry does not need any contact with the object being monitored, and this can be a great advantage when it comes to the deformation monitoring of inaccessible structures. The paper shows a low-cost setup of multiple off-the-shelf digital cameras and projectors used for three-dimensional photogrammetric reconstruction for the purpose of deformation monitoring of structural elements. This photogrammetric system setup was used in an experiment, where a concrete beam was being deformed by a hydraulic actuator. Both static and dynamic loading conditions were tested. The system did not require any physical targets other than to establish the relative orientation between the involved cameras. The experiment proved that it was possible to detect sub-millimetre level deflections given the used equipment and the geometry of the setup.