Miracle-dz/UniFAR-FTUs huggingface dataset:
TYPOLOGY OF NONLINEAR ACTIVITY WAVES IN A LAYERED NEURAL CONTINUUM

Neural tissue, a medium containing electro-chemical energy, can amplify small increments in cellular activity. The growing disturbance, measured as the fraction of active cells, manifests as propagating waves. In a layered geometry with a time delay in synaptic signals between the layers, the delay is instrumental in determining the amplified wavelengths. The growth of the waves is limited by the finite number of neural cells in a given region of the continuum. As wave growth saturates, the resulting activity patterns in space and time show a variety of forms, ranging from regular monochromatic waves to highly irregular mixtures of different spatial frequencies. The type of wave configuration is determined by a number of parameters, including alertness and synaptic conditioning as well as delay. For all cases studied, using numerical solution of the nonlinear equations, there is an interval in delay in which the wave mixing occurs. As delay increases through this interval, during a series of consecutive waves propagating through a continuum region, the activity within that region changes from a single-frequency to a multiple-frequency pattern and back again. The diverse spatio-temporal patterns give a more concrete form to several metaphors advanced over the years to attempt an explanation of cognitive phenomena: Activity waves embody the “holographic memory” (); wave mixing provides a plausible cause of the competition called “neural Darwinism” (); finally the consecutive generation of growing neural waves can explain the discontinuousness of “psychological time” ().
Two‐dimensional electrophoresis analysis of the extracellular proteome of Bacillus cereus reveals the importance of the PlcR regulon

Many virulence factors are secreted by the gram‐positive, spore forming bacterium Bacillus cereus. Most of them are regulated by the transcriptional activator, PlcR, which is maximally expressed at the beginning of the stationary phase. We used a proteomic approach to study the impact of the PlcR regulon on the secreted proteins of B. cereus, by comparing the extracellular proteomes of strains ATCC 14579 and ATCC 14579 Δ plcR, in which plcR has been disrupted. Our study indicated that, quantitatively, most of the proteins secreted at the onset of the stationary phase are putative virulence factors, all of which are regulated, directly or indirectly, by PlcR. The inactivation of plcR abolished the secretion of some of these virulence factors, and strongly decreased that of others. The genes encoding proteins that are not secreted in the ΔplcR mutant possessed a regulatory sequence, the PlcR box, upstream from their coding sequence. These proteins include collagenase, phospholipases, haemolysins, proteases and enterotoxins. Proteins for which the secretion was strongly decreased, but not abolished, in the ΔplcR mutant did not display the PlcR box upstream from their genes. These proteins include flagellins and InhA2. InhA2 is a homologue of InhA, a Bacillus thuringiensis metalloprotease that specifically degrades antibacterial peptides. The mechanism by which PlcR affects the production of flagellins and InhA2 is not known.
Supplying protection: The United Nations and public support for humanitarian intervention

This paper examines the role of the constellation of interveners, along with the approval of international institutions like the United Nations, on public support for military interventions to protect civilians during war. Concerns over burden sharing and free riding have figured prominently in recent debates over the provision, or lack thereof, of humanitarian interventions. An experiment embedded in a survey of a representative sample of the US public shows that citizens are influenced less by the extent of material contributions from other countries than by whether the United Nations sanctions the mission. Further analysis indicates that the United Nations functions as a legitimating device that can help overcome collective action problems, rather than through alternative approaches emphasizing the signaling of information or ensuring greater military resources. The findings have implications for research on the role of international institutions and the domestic politics of support for the use of force.
The safety of flecainide treatment of atrial fibrillation: long‐term incidence of sudden cardiac death and proarrhythmic events

Abstract. Almroth H, Andersson T, Fengsrud E, Friberg L, Linde P, Rosenqvist M, Englund A (Örebro University Hospital, Örebro; Danderyd Hospital and Karolinska Institutet at Danderyd Hospital, Stockholm; and Karolinska Institutet at Stockholm South Hospital, Sweden). The safety of flecainide treatment of atrial fibrillation: long‐term incidence of sudden cardiac death and proarrhythmic events. J Intern Med 2011; 270: 281–290.
Regional UK TTP Registry: correlation with laboratory ADAMTS 13 analysis and clinical features

Thrombotic thrombocytopenic purpura (TTP) is an acute, rare, life‐threatening disorder. This report presents the South East (SE) England registry for TTP, from April 2002 to December 2006, which included 176 patients and 236 acute episodes; 75% of patients were female and 25% were male, overall median age at presentation was 42 years. Mortality was 8·5%, most cases died before treatment was instigated. The main ethnic groups were Caucasian (64%) and Afro Caribbean (27%). Seventy‐seven percent of cases were idiopathic, 5% were congenital and the remaining cases had a defined precipitant. Neurological features were the most prevalent, but cardiac involvement accounted for 42% of presenting features. The overall median number of plasma exchanges (PEXs) to remission was 15; between April 2002 and December 2003, the median number of PEXs was 19 and it was 12 between January 2004 and December 2006 (P < 0·0001). In the latter period, adjuvant therapies were reduced, but Rituximab was increased. ADAMTS 13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) activity was <10% in 74% and 95% of these cases had positive IgG antibodies to ADAMTS 13. Renal impairment and delayed normalisation of platelet count were the main differences between idiopathic and secondary TTP.
Evaluation of SEU Performance of 28-nm FDSOI Flip-Flop Designs

In this paper, a variety of flip-flop (FF) designs fabricated in a commercial 28-nm Fully-Depleted Silicon on Insulator (FDSOI) technology are evaluated for their single-event upset performance with ions and pulsed laser experiments. These FF designs consist of unhardened DFF, hardened DFF with stacked transistors in the inverters, and the layout-optimized DFFs. These DFFs were exposed to alpha particles and heavy ions (HIs). None of the hardened DFFs exhibit any errors up to a Linear Energy Transfer (LET) of 50 MeV*cm2/mg under normal irradiation, and a layout-based hardened DFF started to see errors at a LET of 50 MeV*cm2/mg with the tilt angle of 600. The testing data substantiates effective SEU reduction of these hardened designs. Two-photon absorption (TPA) laser experiments were carried to test these DFF designs, and the results showed that pulsed laser may not be a valid tool to evaluate the FFs designed with nano-scale SOI stacked structures. This brings new challenges in laser hardness assurance for RHBD designs.
Globalization routes: The pursuit of conformity and distinctiveness by top business schools in India

In this article, we examine how leading business schools in India orient themselves locally and globally while pursuing conformity and distinctiveness. We expect that these dynamics are particularly complex in ‘emerging’ economies such as India where liberalization and subsequent economic resurgence have led to more intense global exposure for business schools. By exploring changes in the way these responses are applied over time, we identify four globalization routes in the field. Furthermore, we show that these routes make up two broad zones of global–local interaction. In one, we point to the ability of global practices to serve both global and local compulsions, leading to the diffusion of global norms and practices. In the other, we point to how inherent paradoxes lead to possibilities for moderate and radical global distinctiveness.
Willingness to Donate Organs and Tissues in Vietnam

Context Few studies on public attitudes toward organ and tissue donation have been carried out in Asia. Objective To determine demographic influences on attitudes toward organ and tissue donation in Vietnam. Design Face-to-face interviews. Setting Tan Binh District, Ho Chi Minh City, Vietnam. Participants Random sample of adults (N=785). Main Outcome Measures Awareness of donation and transplantation, acceptance of organ and tissue donation. Results 75% of respondents stated they had heard of organ or tissue donation, but only 55% were aware of organ and tissue transplantation taking place in Vietnam. Forty-eight percent of Buddhists and 27.5% of Christians had either no knowledge or incorrect knowledge about their religion's official position toward donation and transplantation. Sixty-four percent stated they would give consent for the donation of their deceased relative's tissues and organs, 66% would themselves become posthumous donors, and 21% to 22% would donate multiple organs and tissues. A significant association was found between respondents' acceptance of organ and tissue donation and their educational level, sex, occupation, and awareness of transplantation. Most respondents stated that their willingness to donate depended on whether other family members agreed. Many noted the importance of preventing commerce in organ and tissue transplantation but were in favor of providing healthcare for the donor's family or monetary incentives as a reward for donating. Conclusion Nearly two thirds of urban Vietnamese surveyed were willing to donate organs or tissues after death. Their willingness was related to awareness of transplantation, sex, education level, and occupation.
Non-statistical transformed data domain stap algorithm for non-homogeneous environment

This paper introduces a new non-statistical STAP algorithm which is efficient and powerful in non-homogeneous environment. The traditional statistical algorithms using the estimated interference covariance are not optimal in heterogeneous clutter. The non-statistical approach which uses primary data only and is appropriate to extremely heterogeneous case is presented. The transformed data domain (TDD) algorithm which is more simple and efficient compared to the original direct data domain (D3) algorithm is proposed. The received space-time signal is transformed to beam-doppler domain and weight to minimize interferences is obtained in this space. The performance of the proposed non-statistical STAP is tested in SIRV clutter model environment and compared to that of the approach which employs traditional statistical algorithm.
Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

In AD, an imbalance between Aβ production and removal drives elevated brain Aβ levels and eventual amyloid plaque deposition. APP undergoes nonamyloidogenic processing via α-cleavage at the plasma membrane, amyloidogenic β- and γ-cleavage within endosomes to generate Aβ, or lysosomal degradation in neurons. Considering multiple reports implicating impaired lysosome function as a driver of increased amyloidogenic processing of APP, we explored the efficacy of targeting transcription factor EB (TFEB), a master regulator of lysosomal pathways, to reduce Aβ levels. CMV promoter-driven TFEB, transduced via stereotactic hippocampal injections of adeno-associated virus particles in APP/PS1 mice, localized primarily to neuronal nuclei and upregulated lysosome biogenesis. This resulted in reduction of APP protein, the α and β C-terminal APP fragments (CTFs), and in the steady-state Aβ levels in the brain interstitial fluid. In aged mice, total Aβ levels and amyloid plaque load were selectively reduced in the TFEB-transduced hippocampi. TFEB transfection in N2a cells stably expressing APP695, stimulated lysosome biogenesis, reduced steady-state levels of APP and α- and β-CTFs, and attenuated Aβ generation by accelerating flux through the endosome-lysosome pathway. Cycloheximide chase assays revealed a shortening of APP half-life with exogenous TFEB expression, which was prevented by concomitant inhibition of lysosomal acidification. These data indicate that TFEB enhances flux through lysosomal degradative pathways to induce APP degradation and reduce Aβ generation. Activation of TFEB in neurons is an effective strategy to attenuate Aβ generation and attenuate amyloid plaque deposition in AD. SIGNIFICANCE STATEMENT A key driver for AD pathogenesis is the net balance between production and clearance of Aβ, the major component of amyloid plaques. Here we demonstrate that lysosomal degradation of holo-APP influences Aβ production by limiting the availability of APP for amyloidogenic processing. Using viral gene transfer of transcription factor EB (TFEB), a master regulator of lysosome biogenesis in neurons of APP/PS1 mice, steady-state levels of APP were reduced, resulting in decreased interstitial fluid Aβ levels and attenuated amyloid deposits. These effects were caused by accelerated lysosomal degradation of endocytosed APP, reflected by reduced APP half-life and steady-state levels in TFEB-expressing cells, with resultant decrease in Aβ production and release. Additional studies are needed to explore the therapeutic potential of this approach.
Dietary calcium decreases plasma cholesterol level only in female but not in male hamster fed a high cholesterol diet.

OBJECTIVE To investigate the effect of dietary calcium on plasma lipoprotein profile in castrated and ovariectomized hamsters. METHODS Male, castrated, female and ovariectomized hamsters (n=36 each group) were randomly divided into three sub-groups (n=12) and fed one of the three diets containing 0, 2, and 8 g calcium per kg diet for a period of six weeks. Changes in plasma lipoprotein profile were monitored at the end of week 0, 3 and 6. RESULTS Plasma total cholesterol (TC), non-high density lipoprotein cholesterol (non-HDL-C), triacylglycerols (TG) and TC/HDL-C were decreased only in intact female and ovariectomized hamsters. In contrast, three levels of dietary calcium had no effect on lipoprotein profiles in both intact male and castrated hamsters. CONCLUSION Beneficial modification of lipoprotein profile by dietary calcium was gender-dependent at least in hamsters.
Cutting the high cost of testing

A modeling approach to the overly long testing of analog and mixed-signal devices that saves substantially on time and cost is described. The discussion focuses on the particular case of a 13 bit analog-to-digital converter (ADC). The problems that arise in testing ADCs are identified, showing that the success of the test method depends critically on the quality of the model. Two types of models are examined, physical-sensitivity-based models and empirical-learning-based models, and it is noted that the latter are especially attractive for performance-testing applications like the ADC example. An 18-parameter model of the 13 bit ADC was developed using a combination of physical and empirical modeling techniques and was highly successful. With an array process to speed up the computations, the computational overhead can be kept below 1 s per device, so the test time, which is reduced by a factor of 128, becomes negligible. <<ETX>>
Anti‐tumor T cell response and protective immunity in mice that received sublethal irradiation and immune reconstitution

To test whether homeostasis‐driven T cell proliferation in reconstituted lymphodepleted hosts would improve the therapeutic efficacy of tumor vaccines, normal mice and reconstituted lymphopenic mice (RLM; C57BL/6 mice rendered lymphopenic with sublethal total‐body irradiation and reconstituted with naive splenocytes) were used in the vaccination and challenge experiments with weakly immunogenic F10 melanoma cells. Only limited protection was observed in vaccinated normal mice (16.7%), whereas significantly greater protection was induced in vaccinated RLM (63.2%). Protective immunity in RLM depended on CD8 T cells. Following vaccination, a significant increase in the percentage of CD44hiCD62Llo T cells was detected in the tumor vaccine‐draining lymph node (TVDLN) of vaccinated RLM compared to that of vaccinated normal mice. After in vitro stimulation, effector T cells generated from TVDLN of vaccinated RLM produced more IFN‐γ than T cells from vaccinated normal mice, and contained more melanoma‐specific T cells, as assessed by ELISA and intracellular cytokine staining. This study suggests that vaccination of reconstituted lymphopenic hosts could elicit superior anti‐tumor immunity compared to normal hosts, highlighting the potential clinical benefit of performing tumor vaccination during immune reconstitution.
El uso simultáneo de crédito formal, informal y el desahorro: Explorando el comportamiento financiero de los hogares en Argentina

In order to promote public policies aimed at enhancing financial inclusion, the Central Bank of Argentina makes periodic efforts to study, measure and analyze the processes of access and use of financial services by households in Argentina. The main objective of this paper is to use the information gathered by INDEC's Permanent Household Survey to explore the use of credit (from both formal and informal financial providers) and dissaving to understand the determinants of household financial behavior. Using multivariate probit models, we document the effects of different demographic and socio-economic variables on the estimated probability of adopting certain financial behaviors. These models can also be a statistically appropriate way to analyze the simultaneous determination of different observed actions in households' financial management. Thus, controlling for a set of exogenous variables while adding explanatory variables as endogenous regressors, we show that the inclusion of the latter is both statistically relevant and useful in identifying the existence of substitutability between some financial behaviors and of complementarity among others.
Self-Compensating OCP Control Scheme for Primary-Side Controlled Flyback AC/DC Converters

Primary-side controlled universal-line flyback converters have been widely used in low-power applications due to their simplicity, low standby power, and low cost. However, conventional OCP schemes normally cause too large a variation in output current when the input voltage varies. This paper proposes a self-compensating OCP circuit to achieve a high-precision constant current at different input voltages which can be used in flyback converters working in discontinues conduction mode. It consists of a CS S/H circuit and a dynamic OCP voltage reference circuit. Compared with conventional OCP circuits, it does not need an extra compensation circuit. To verify the feasibility and performance of the proposed circuit, an IC controller that uses the proposed OCP circuit has been designed and fabricated in 0.35 μm 5-V/40-V high-voltage CMOS technology. Experimental results show that the constant output current precision of the prototype is within ±1% when the input line voltage changes from 85 to 265 Vac. In the common line voltage range ($\rm{110-220\ Vac}$ ), the output current regulation accuracy can reach a level as high as ± 0.3%.
Urban and rural factors in the aetiology of cancer

The incidence of cancer, or the mortality attributed to it, has been compared in urban and rural residents in 13 populations. In each case, the incidence (or mortality) has been higher in the urban areas in each sex, the ratios varying from a minimum of 1.03 to I in men in Japan to 1.63 to I in men in Denmark. Examination of 26 separate types of cancer showed that 23 tended to be more common in towns, I (myeloma) to be evenly distributed, and 2 (cancers of the lip and eye) to be more common in the countryside. The urban excess was greatest for cancers of the bladder, larynx, liver, lung, mouth and pharynx, and oesophagus, and least for leukaemia and non‐Hodgkin's lymphoma. It is concluded that differences in personal behaviour (cigarette smoking, alcohol consumption, sexual promiscuity, exposure to ultraviolet light, type of diet, and family size) are the principal factors responsible for the urban excess. Other factors include general atmospheric pollution, occupational hazards, genetic differences in susceptibility, and artefacts of diagnosis and recording. The rural excess was marked for cancer of the lip in both sexes, but less marked and clearly evident only in men for cancer of the eye. Three‐quarters of eye cancers are melanomas and the excess incidence in rural areas provides some weak support for the idea that exposure to sunlight contributes to the production of the disease.
Analysis of Heart Rate and Respiratory Patterns in Sudden Infant Death Syndrome Victims and Control Infants

ABSTRACT. Retrospective analyses of patterns of breathing and heart rate variability obtained by visual inspection and spectral analysis of ECG and respiratory activity have provided markers associated with subsequent death in a referred population of infants at high risk for sudden infant death syndrome (SIDS). Such markers include breathing patterns characterized by excessive apneic pauses and periodic breathing, heart rate spectra characterized by increased low frequency oscillations, and respiratory activity spectra characterized by a widened “bandwidth” during regular breathing. To test whether such measurements could distinguish SIDS cases and randomly selected controls from a population study the data from 10 cases and 100 age-matched control subjects were analyzed blind. The code was disclosed after completion of the analysis. We found that none of the markers served to distinguish the SIDS cases from the controls in the population at large. This observation may indicate important physiological differences between infants destined to die in the referred high risk population and infants who die of SIDS at large. The possible reasons for our inability to identify the group of SIDS in the general population, as compared to the group of deaths in the referred high risk group are: (1) different disease processes in the two groups, (2) difference responses to the same disease process in the two groups, (3) a response reflecting the psychosocial setting of the referred high risk population, (4) methodological differences between this and previous studies. We conclude that these markers are not of value in screening the population at large.