Miracle-dz/UniFAR-FTUs huggingface dataset:
Seven level asymmetric inverters with coupled inductors

This paper proposes two seven level asymmetric inverter with coupled inductors that enable a reduction in the number of controlled switching devices. However, the lack of redundant states and difference in the maximum pole voltages reduce the performance of the inverters due to higher winding currents and saturation of magnetic core. For mitigating those issues, a coupled inductor with elevated magnetizing inductance is used. The operation principle, conducting states and modulation strategy are described. Simulation and experimental results demonstrate the feasibility of proposed topology.
Phosphoinositide Recognition Domains

Domains or modules known to bind phosphoinositides have increased dramatically in number over the past few years, and are found in proteins involved in intracellular trafficking, cellular signaling, and cytoskeletal remodeling. Analysis of lipid binding by these domains and its structural basis has provided significant insight into the mechanism of membrane recruitment by the different cellular phosphoinositides. Domains that target only the rare (3‐phosphorylated) phosphoinositides must bind with very high affinity, and with exquisite specificity. This is achieved solely by headgroup interactions in the case of certain pleckstrin homology (PH) domains [which bind PtdIns(3,4,5)P3 and/or PtdIns(3,4)P2], but requires an additional membrane‐insertion and/or oligomerization component in the case of the PtdIns(3)P‐targeting phox homology (PX) and FYVE domains. Domains that target PtdIns(4,5)P2, which is more abundant by some 25‐fold, do not require the same stringent affinity and specificity characteristics, and tend to be more diverse in structure. The mode of phosphoinositide binding by different domains also appears to reflect their distinct functions. For example, pleckstrin homology domains that serve as simple targeting domains recognize only phosphoinositide headgroups. By contrast, certain other domains, notably the epsin ENTH domain, appear to promote bilayer curvature by inserting into the membrane upon binding.
PREPROCESSING AND PRETRAINING OF MULTI-LAYER FEED FORWARD NEURAL NETWORK MODEL

Multi-layer Feed Forward Neural Network (MFFNN) model obtains its data by learning from the real-world environment. Also MFFNN dynamically recognizes the type of input information through their weights and properties. Learning in MFFNN model is considerably slow because biases and weights have to be updated in each epoch during learning. Currently, data preprocessing and pre-training are the contributing factors in developing efficient techniques for fast MFFNN processing at high accuracy and reduced training time. Finding an effective preprocessing technique is an active area of research. The main problem for supervised MFFNN model lies in finding the suitable weights during training in order to improve training time and achieve higher accuracy. The important issue in the training process of existing MFFNN models is in the initialization of the weights. However, this process is random and creates the paradox of low accuracy and high training time. This study reviews data pre-processing and pre-training techniques in Multi-layer Feed Forward Neural Network. Weights Linear Analysis (WLA) is the newest composition of data preprocessing and pre-training techniques for MFFNN models to increase their classification accuracy and to reduce training time. MFFNN model WLA as a preprocessing and pre-training technique acts as an efficient intelligent classification that can be used for learning the model and is applicable to different domains.
OBSTACLE PROBLEMS FOR SCALAR CONSERVATION LAWS

Ce travail a pour objet l'etude de problemes d'obstacles bilateraux pour des lois de conservation scalaires quasi-linenaires du premier ordre associees a des conditions aux limites de Dirichlet. On donne d'abord une formulation entropique qui garantit l'unicite. On justifie alors l'existence d'une solution par utilisation de la methode de penalisation et au moyen de la notion de processus entropique solution due aux proprietes des suites bornees dans L∞ . Enfin, on etudie le comportement de cette solution et ses proprietes de stabilite en fonction des contraintes d'obstacle associees.
Biochemical Sequence Analyses of GES-1, a Novel Class A Extended-Spectrum β-Lactamase, and the Class 1 Integron In52 from Klebsiella pneumoniae

ABSTRACT Klebsiella pneumoniae ORI-1 was isolated in 1998 in France from a rectal swab of a 1-month-old girl who was previously hospitalized in Cayenne Hospital, Cayenne, French Guiana. This strain harbored a ca. 140-kb nontransferable plasmid, pTK1, that conferred an extended-spectrum cephalosporin resistance profile antagonized by the addition of clavulanic acid, tazobactam, or imipenem. The gene for GES-1 (Guiana extended-spectrum β-lactamase) was cloned, and its protein was expressed in Escherichia coli DH10B, where this pI-5.8 β-lactamase of a ca. 31-kDa molecular mass conferred resistance to oxyimino cephalosporins (mostly to ceftazidime). GES-1 is weakly related to the other plasmid-located Ambler class A extended-spectrum β-lactamases (ESBLs). The highest percentage of amino acid identity was obtained with the carbenicillinase GN79 from Proteus mirabilis; with YENT, a chromosome-borne penicillinase fromYersinia enterocolitica; and with L-2, a chromosome-borne class A cephalosporinase from Stenotrophomonas maltophilia(36% amino acid identity each). However, a dendrogram analysis showed that GES-1 clustered within a class A ESBL subgroup together with ESBLs VEB-1 and PER-1. Sequencing of a 7,098-bp DNA fragment from plasmid pTK1 revealed that the GES-1 gene was located on a novel class 1 integron named In52 that was characterized by (i) a 5′ conserved segment containing an intI1 gene possessing two putative promoters, P1 and P2, for coordinated expression of the downstream antibiotic resistance genes and an attI1 recombination site; (ii) five antibiotic gene cassettes, blaGES-1,aac(6′)Ib′ (gentamicin resistance and amikacin susceptibility), dfrXVb (trimethoprim resistance), a novel chloramphenicol resistance gene (cmlA4), andaadA2 (streptomycin-spectinomycin resistance); and (iii) a 3′ conserved segment consisting of qacEΔ1 andsulI. The blaGES-1 andaadA2 gene cassettes were peculiar, since they lacked a typical 59-base element. This work identified the second class A ESBL gene of a non-TEM, non-SHV series which was located in the plasmid and integron, thus providing it additional means for its spread and its expression.
Treatment of Hickman Catheter Sepsis Using Antibiotic Lock Technique

Abstract Antibiotic lock therapy, an alternative treatment for Hickman catheter sepsis, was evaluated in six recipients of prolonged outpatient intravenous therapy. Twenty-two episodes of catheter sepsis were identified, involving coagulase-negative staphylococci (11), gram-negative bacilli (3), gram-positive bacilli (1), yeast (4), and mixed bacteria or fungi (3). In a select group of patients, treatment was successful 92% of the time.
Can the neuropathic pain scale discriminate between non-neuropathic and neuropathic pain?

OBJECTIVES 1) To determine if the neuropathic pain scale (NPS) can be used to classify chronic pain patients (CPPs) as having primarily neuropathic vs non-neuropathic pain, and furthermore; 2) to determine what, if any, cut-off score can be used to reliably make this determination. DESIGN A total of 305 CPPs consecutive admissions to The Rosomoff Pain Center were administered the NPS and were assigned a diagnosis according to the physical examination and all available test results. CPPs with a diagnosis of chronic radiculopathy and spondylolysis/degenerative arthritis were segregated into two groups for the purposes of having a group representative of neuropathic pain (chronic radiculopathy) and non-neuropathic pain (spondylolysis/degenerative arthritis). Applying neuropathic pain criteria to each "of these two groups": a neuropathic pain "subtype" was identified within the chronic radiculopathy group; and, a non-neuropathic pain "subtype" was identified within the spondylolysis/degenerative arthritis group. This step was performed in order to assure that the CPPs selected for further analysis were truly representative of neuropathic and non-neuropathic pain. Discriminant function analysis was then employed to determine if NPS scoring could differentiate between these two "subtypes. " Results from the discriminant function analysis model were utilized to derive an NPS cut-off score above which CPPs would be classified as having neuropathic pain. For the diagnoses of myofascial pain syndromes, spinal stenosis, epidural fibrosis, fibromyalgia, complex regional pain syndromes 1 and 2, and failed back surgery syndrome, a predicted NPS score was calculated and compared with the cut-off score. SETTING Multidisciplinary pain facility. PATIENTS Chronic pain patients. RESULTS The NPS appeared to be able to separate CPPs into neuropathic pain vs non-neuropathic pain subtypes. The derived cut-off score from the model was 5.53. Myofascial pain syndrome and spinal stenosis had predictive scores lower than this cut-off score at 3.81 and 4.26, respectively. Epidural fibrosis, fibromyalgia, complex regional pain syndromes 1 and 2, and failed back surgery syndrome had predictive scores higher than the cut-off score at 6.15, 6.35, 6.87, 9.34, and 7.19, respectively. CONCLUSIONS The NPS appears to be able to discriminate between neuropathic and non-neuropathic pain. A debate is currently raging as to whether diagnoses, such as fibromyalgia and complex regional pain syndrome 1, can be classified as neuropathic. Our NPS cut-off score results suggest that these diagnoses may have a neuropathic pain component. The reliability and validity of our NPS method will need to be tested further in other neuropathic pain models, such as diabetic peripheral neuropathic pain.
Drinking Motives, Alcohol Expectancies, Self-Efficacy, and Drinking Patterns

The current study focused on the associations between drinking motives, alcohol expectancies, self-efficacy, and drinking behavior in a representative sample of 553 Dutch adolescents and adults. Data were gathered by means of self-report questionnaires and a 14-days drinking diary. A model was postulated in which negative expectancies and self-efficacy were directly associated with drinking, and in which drinking motives mediated the associations between positive expectancies, and drinking. The findings of multivariate analyses showed that drinking motives were related to general indicators of drinking and to drinking levels in specific situations. Furthermore, self-efficacy was moderately related to all drinking variables. Negative expectancies were related to general drinking variables but hardly to drinking in specific situations. Positive expectancies were hardly related to drinking in multivariate analyses and therefore mediation models could not be tested. No systematic moderator effects were apparent for age and gender on the associations between drinking motives, alcohol expectancies, self-efficacy, and drinking.
First branchial cleft sinus presenting with cholesteatoma

Disorders of the first branchial cleft are rare and often present difficulties in diagnosis. A case is reported that presented with the clinical and histological features of cholesteatoma. The embryology, diagnosis and treatment of branchial arch defects are also reviewed. The case highlights the fact that a high index of suspicion should be aroused for patients with a discharging ear in the presence of an intact tympanic membrane.
PARALLEL HYBRID ACTIVE POWER FILTER FOR STATIC REACTIVE POWER AND HARMONICS COMPENSATION WITH SOGI-PLL

In this paper, according to the lack of relevant studies based on reactive power compensation, the control method related to this subject has been investigated and applied to the Parallel Hybrid Active Power Filter (P-HAPF). Firstly, the dq base control algorithm is applied for harmonic compensation. Then, the reactive power compensation control which is supplied by active filter of hybrid active filter is added. Finally, the static reactive power and harmonic compensation is achieved by P-HAPF. All controllers are written by FORTRAN language in PSCAD/EMTDC.
Indexation et intégration de ressources textuelles à l'aide d'ontologies : application au domaine biomédical

De nombreuses decouvertes scientifiques sont contraintes aujourd'hui par la difficile integration des donnees misent a disposition dans differentes ressources. L'utilisation d'ontologies pour indexer et integrer les ressources de donnees est un moyen de valoriser la connaissance d'un domaine en facilitant la recherche et la fouille de donnees. Dans cet article nous presentons un mecanisme d'indexation de ressources de donnees textuelles dirige par les ontologies. Nous detaillons la creation et l'utilisation d'un index de ressources de donnees biomedicales qui fournit un acces uniforme a plus d'une vingtaine de ressources indexees avec plus de 200 ontologies. Cet index est accessible via la plateforme Web BioPortal du Centre National pour les Ontologies Biomedicales (NCBO) : http://bioportal.bioontology. org/.
Antibiotic and Biosurfactant Properties of Cyclic Lipopeptides Produced by Fluorescent Pseudomonas spp. from the Sugar Beet Rhizosphere

ABSTRACT Cyclic lipopeptides (CLPs) with antibiotic and biosurfactant properties are produced by a number of soil bacteria, including fluorescent Pseudomonas spp. To provide new and efficient strains for the biological control of root-pathogenic fungi in agricultural crops, we isolated approximately 600 fluorescent Pseudomonas spp. from two different agricultural soils by using three different growth media. CLP production was observed in a large proportion of the strains (approximately 60%) inhabiting the sandy soil, compared to a low proportion (approximately 6%) in the loamy soil. Chemical structure analysis revealed that all CLPs could be clustered into two major groups, each consisting of four subgroups. The two major groups varied primarily in the number of amino acids in the cyclic peptide moiety, while each of the subgroups could be differentiated by substitutions of specific amino acids in the peptide moiety. Production of specific CLPs could be affiliated with Pseudomonas fluorescens strain groups belonging to biotype I, V, or VI. In vitro analysis using both purified CLPs and whole-cell P. fluorescens preparations demonstrated that all CLPs exhibited strong biosurfactant properties and that some also had antibiotic properties towards root-pathogenic microfungi. The CLP-producing P. fluorescens strains provide a useful resource for selection of biological control agents, whether a single strain or a consortium of strains was used to maximize the synergistic effect of multiple antagonistic traits in the inoculum.
Improved control strategy to mitigate electromechanical wave propagation using PSS

This paper addresses the problem of electromechanical wave propagation in power systems. To mitigate this type of disturbance, this paper proposes a remote control strategy that could be applied to power system stabilizers. This strategy is based on wide-area measurements, and exploits the disturbance propagation speed to introduce an extra damping torque simul-taneously with the disturbance arrival. Simulation results show that the application of such strategy improves the power system dynamics.
Korpuslinguistik in der linguistischen Lehre: Erfolge und Misserfolge

Fur die sprachwissenschaftliche Ausbildung an den Universitaten ist es zwar unabdingbar, die Studierenden in die Theorie und Methoden der Korpuslinguistik einzufuhren, doch als Lehrperson kampft man dabei mit einer Reihe von Problemen, denn das technische und methodische Know-how der Studierenden ist oft sehr heterogen. Zudem zeigt sich die Wichtigkeit, die Studierenden fur korpuslinguistisches Arbeiten begeistern zu konnen, indem sie an attraktives Anschauungsmaterial herangefuhrt werden. Im Folgenden zeige ich an einigen Beispielen, welche Themen in den Bereichen Semantik, Textlinguistik, Diskursund der Kulturanalyse sinnvollerweise korpuslinguistisch bearbeitet werden konnen. Zudem versuche ich anhand des Nutzungsverhaltens meiner Online-Einfuhrung in die Korpuslinguistik die Bedurfnisse von Anwendern an Methoden und Werkzeuge der Korpuslinguistik abzuleiten.
Factors affecting performance of PACS.

We experimentally constructed a personal-computer-based Picture Archiving and Communication System (PACS) for color images of dermatology clinics. This system should especially satisfy such a demand as to be able to retrieve an image within a few seconds from the database residing in a remote server. Our two objectives in the experiment were: To examine how much time was consumed in each part of PACS while it does a series of jobs, from the requesting of an image to its display on the screen of the workstation of the user. The other objective was to see if a personal-computer-based PACS could satisfy our criteria. Total retrieving time, data reading time, data transporting time and image displaying time were measured. Total retrieving time can be divided into three procedures: Data reading time, data transporting time, image displaying time. Data reading time was about 0.6 second for reading an image with the size of 1 mega bytes (MB). Data reading time and the size of data were linearly correlated. Data transporting time was about 11 seconds for transporting an image with the size of 1 MB through EtherTalk, and 66 seconds through LocalTalk. Data transporting time and the size of the data were also linearly correlated. Data reading time and data transporting time was able to be reduced largely by compression technique. However, smaller data give other important effects to the network system besides reducing the time of data reading, data transporting and data displaying. Most Local Area using image Network (LAN) systems, such as EtherTalk, adopt Carrier Sense Multiple Access with Collision Detection (CSMA/CD) for the way of accessing to other computer. In CSMA/CD, transporting performance suddenly declines if the congestion of signal in a network gets beyond a critical level. This situation fatally impairs the performance of a network. We concluded that data compression plays an important role to improve the performances of PACS, especially those of a server and the network system. A personal-computer-based PACS with EtherTalk and an image compression/decompression hardware, e.g., CL550A chip, satisfies our criteria.
Explorer An Incremental Parser for Abstract Meaning Representation

Abstract Meaning Representation (AMR) is a semantic representation for naturalMeaning Representation (AMR) is a semantic representation for natural language that embeds annotations related to traditional tasks such as named entity recognition, semantic role labeling, word sense disambiguation and co-reference resolution. We describe a transition-based parser for AMR that parses sentences leftto-right, in linear time. We further propose a test-suite that assesses specific subtasks that are helpful in comparing AMR parsers, and show that our parser is competitive with the state of the art on the LDC2015E86 dataset and that it outperforms state-of-the-art parsers for recovering named entities and handling polarity.
Efficacy of acupuncture as a treatment for chronic shoulder pain.

OBJECTIVES The aim of this study was to evaluate the efficacy of acupuncture as a treatment for chronic shoulder pain and to compare the efficacy of individualized acupuncture to fixed, standard point acupuncture treatment. DESIGN The study was a single-blind randomized, controlled trial. SETTINGS/LOCATION The study was conducted in an outpatient rheumatology clinic at the VA Medical Center of Philadelphia. SUBJECTS The participants were adults with shoulder pain for at least 8 weeks with a diagnosis of osteoarthritis or rotator cuff tendonitis and a total Shoulder Pain and Disability Index (SPADI) score of > or =30. INTERVENTIONS Thirty-one (31) subjects were randomized to one of three treatment groups: individualized acupuncture points according to the approaches of Traditional Chinese Medicine; fixed, standard acupuncture points conventionally used for shoulder pain; and sham nonpenetrating acupuncture. Subjects received 12 treatments over 6 weeks and were reassessed using the SPADI at the end of the 6 weeks. OUTCOME MEASURES The primary outcome evaluated was the mean change in total SPADI score in each group from baseline to 6 weeks. RESULTS After 6 weeks of treatment, the mean total SPADI score improved in all three groups, but the change was clinically significant (> or =10 points) only in groups 1 and 2 (-20.3 and -20.4, respectively, versus -6.5 in group 3). The treatment effects of groups 1 and 2 compared to the sham acupuncture group were -13.8 (95% confidence interval: -2.2 to -25.4, p < 0.015) and -13.9 (-2.0 to -25.8, p < 0.013), respectively. There was no difference between the individualized acupuncture and standardized acupuncture treatments. CONCLUSIONS Acupuncture may be an effective treatment for chronic shoulder pain. There may be no difference in efficacy between individualized and standardized acupuncture treatment. This suggests that the use of standard points may make treatment easier for patient care and for further research studies.
Detection of cholangiocarcinoma with magnetic resonance spectroscopy of bile in patients with and without primary sclerosing cholangitis

Background: Early detection of cholangiocarcinoma (CC) is very difficult, especially in patients with primary sclerosing cholangitis (PSC) who are at increased risk of developing CC. Purpose: To evaluate 1H magnetic resonance spectroscopy (1H-MRS) of bile as a diagnostic marker for CC in patients with and without PSC. Material and Methods: The institutional review board approved the study, and all patients gave informed consent. Bile from 49 patients was sampled and investigated using 1H-MRS. MR spectra of bile samples from 45 patients (18 female; age range 22–87 years, mean age 57 years) were analyzed both conventionally and using computerized multivariate analysis. Sixteen of the patients had CC, 18 had PSC, and 11 had other benign findings. Results: The spectra of bile from CC patients differed from the benign group in the levels of phosphatidylcholine, bile acids, lipid, and cholesterol. It was possible to distinguish CC from benign conditions in all patients with malignancy. Two benign non-PSC patients were misclassified as malignant. The sensitivity, specificity, and accuracy were 88.9%, 87.1%, and 87.8%, respectively. Conclusion: With 1H-MRS of bile, cholangiocarcinoma could be discriminated from benign biliary conditions with or without PSC.
Altered Sumoylation of p63α Contributes to the Split-Hand/Foot Malformation Phenotype

p63 mutations have been identified in several developmental abnormalities, including splithand/foot malformation (SHFM). In this study, we demonstrate that the C-terminal domain of p63αassociates with the E2 ubiquitin conjugating enzyme, Ubc9. A p63α mutation, Q634X, whichnaturally occurs in SHFM modulated the interaction of p63α with Ubc9 in yeast genetic assay.Furthermore, Ubc9 catalyzed the conjugation of p63α with small ubiquitin modifier-1 (SUMO-1),which covalently modified p63α in vitro and in vivo at two positions (K549E and K637E), eachsituated in a SUMO-1 modification consensus site (? KXD/E). In addition, p63? mutations (K549Eand K637E) abolished sumoylation of p63α, dramatically activated transactivation properties ofTAp63α, and inhibited the dominant-negative effect of ΔNp63α. These p63? mutations also affectedthe transcriptional regulation of gene targets involved in bone and tooth development (e.g., RUNX2and MINT) and therefore might contribute to the molecular mechanisms underlying the SHFMphenotype.