Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of business networking on the transfer of knowledge: implications for the diffusion of innovations

This paper examines the impact of networking on learning via the transfer of tacit knowledge and in turn, innovation diffusion for Australian regional SMEs. The findings suggest that Australian regional industry cluster/networks play an important role in facilitating "learning" via the transfer of tacit knowledge for SMEs. In turn, a small number of firms benefit from the diffusion of innovation. In contrast to past studies, this study identified minimal evidence of SMEs collaborating on joint supply-side or marketing opportunities. The findings suggest that while SMEs do participate in Australian regional cluster/networks and knowledge is transferred amongst some members - innovation diffusion and transfer on the desired scale does not result. A number of reasons may be the cause for this; Australians may be less trusting in their approach to business, hence developing a culture that includes collaborative activities may require time. In addition, government policies based predominantly on traditional rational economic models may not be appropriate for growing SMEs. More research is required to understand their goals and the factors affecting their decision-making before developing policies aimed at assisting them.
Data Driven Approximation with Bounded Resources

This paper proposes BEAS, a resource-bounded scheme for querying relations. It is parameterized with a resource ratio α ∈ (0,1], indicating that given a big dataset D, we can only afford to access an α-fraction of D with limited resources. For a query Q posed on D, BEAS computes exact answers Q(D) if doable and otherwise approximate answers, by accessing at most α|D| amount of data in the entire process. Underlying BEAS are (1) an access schema, which helps us identify and fetch the part of data needed to answer Q, (2) an accuracy measure to assess approximate answers in terms of their relevance and coverage w.r. t. exact answers, (3) an Approximability Theorem for the feasibility of resource-bounded approximation, and (4) algorithms for query evaluation with bounded resources. A unique feature of BEAS is its ability to answer unpredictable queries, aggregate or not, using bounded resources and assuring a deterministic accuracy lower bound. Using real-life and synthetic data, we empirically verify the effectiveness and efficiency of BEAS.
Do restrictive and bingeing/purging subtypes of anorexia nervosa differ on central coherence and set shifting?

OBJECTIVE Anorexia nervosa (AN) has been associated with weak central coherence (CC) and weak set shifting (SS). The main aim of this study was to examine possible differences between restrictive AN (AN-R) and bingeing/purging AN (AN-BP) on these features. METHODS A total of 31 patients with AN-R, 20 patients with AN-BP and 26 healthy controls (HC) completed five neuropsychological tests (Block Design, Object Assembly, an adapted task-switching paradigm, Wisconsin Card Sorting Test and Trail Making Test). RESULTS Using Block Design and Object Assembly, indicative for CC, AN-R patients performed significantly worse than AN-BP patients and HC, without any difference between AN-BP and HC. On SS measures, no group differences were observed. DISCUSSION The results suggest that cognitive profiles of AN-R and AN-BP patients differ significantly on CC and not on SS. Our current findings support the idea that the two subtypes of AN have a distinctive underlying nature and might need a different approach in cognitive remediation.
Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR)

Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the nuclear receptor superfamily. These transcription factors are predominantly expressed in the liver, where they are activated by structurally diverse compounds, including many drugs and endogenous substances. CAR and PXR regulate the expression of a broad range of genes, which contribute to transcellular transport, bioactivation, and detoxification of numerous xenochemicals and endogenous substances. This article discusses the importance of these receptors for pharmacology and toxicology, emphasizing the role of individual drugs and natural products as agonists, indirect activators, inverse agonists, and antagonists of CAR and PXR.
Adoptive immunotherapy in patients with recurrent malignant glioma: preliminary results of using autologous whole-tumor vaccine plus granulocyte-macrophage colony-stimulating factor and adoptive transfer of anti-CD3-activated lymphocytes.

OBJECT This trial was designed to determine the ability of autologous whole-tumor cell vaccines to induce cell mediated immune responses in patients with recurrent malignant glioma, as well as to determine whether combining such vaccination with adoptive transfer of in vitro activated T lymphocytes prolongs patient survival. METHODS Nineteen patients with recurrent malignant glioma, in whom previous external beam radiotherapy and at least one course of chemotherapy had failed were vaccinated twice with irradiated autologous whole tumor cells by using granulocyte-marcrophage colony-stimulating factor as an adjuvant. Patients then underwent leukapheresis followed by adoptive transfer of peripheral blood lymphocytes activated in vitro with anti-CD3 and interleukin-2. In vivo immune response, radiological response, clinical outcome, and survival were monitored. Seventeen patients developed a delayed-type hypersensitivity (DTH) response to vaccination that appeared to be directed against the autologous tumor. In eight patients there was radiological evidence of a response and in five there was evidence of clinical improvement. Median survival was 12 months (range 6-28 months), and both the presence of a DTH response and the radiological response correlated with survival (p < 0.02 and p < 0.04, respectively). CONCLUSIONS These preliminary results suggest that autologous whole-tumor cell vaccines induce a cell-mediated immune response, which appears to be tumor specific in most patients. Furthermore, vaccination combined with adoptive immunotherapy with in vitro activated cells may induce a radiologically demonstrated tumor response and improved survival despite a condition of advanced disease and immunosuppression resulting from previous treatment or tumor burden. Further studies of immunotherapy are warranted.
Cultural and Physical Space as a Condition of Artistic Vision: The Aegean in Greek Artists Maleas, Ghikas and Tetsis

The article investigates creative inspiration from, and response to, the Aegean Sea and islands. Inspiration during the 20th century relates to the return to what creators perceived as a civilizing bosom. Some examples of both the conditions and the fruit of modern creativity springing from Aegean islands are examined against this ancient and archetypal background, both natural and cultural; plus, a particular gymnastics of artistic vision. This exploration is pursued through discussions on themes such as the following: The material and spiritual formation of Post-Byzantine Aegean space: the deep descriptive (ekphrastic) faculty and tradition ingrained and recovered here, linked with the appreciation of great views from high rocks over planes, gorges and the open sea, which informed the urban design of Byzantine cities. The sophisticated manner of adjustment to, and appropriation of, mountainous physical topography. Prismatic architectural forms are in constant discourse with the natural topography and have affected artistic representation. The particular role of the Aegean in the formation of important artists and creators: modern intuitive interaction with the Aegean natural beauty, hard and exhilarating light, and heritage, is both material and spiritual. As is shown, the Aegean expresses the culture-nature dialectic par excellence, exemplified in the surreal metaphysical clarity and plasticity of islands like Santorini and Hydra. There have been foreign (for instance, Brancusi’s, Giacometti’s and Modigliani’s) as well as indigenous modern creative responses to the plastic values of the Aegean and its art. Modern Greek artists like Konstantinos Maleas explored and depicted the many pictorial dimensions of islandness as the epitome of Greek space. The paper focuses on his work inspired by Santorini. Besides Maleas, the analysis stresses the particular role of the Aegean in the formation of Nikos Hadjikyriakos Ghikas and Panagiotis Tetsis, both inspired by the island of Hydra. In all three cases, it is shown how, in parallel with the effects of the Aegean, these artists also communicated with the pictorial traditions of the West as well as the East, particularly with Japanese art.
Central action of angiotensin and hypertension--increased central vasomotor outflow by angiotensin.

Sympathetic nerve activities in chloralose-anesthetized dogs were recorded directly during infusions of angiotensin into vertebral artery and femoral vein. 1. With vertebral artery infusion of angiotensin arterial pressure increased to 27 ± 11.1 mmHg and pressure rising began 20 ± 6.6 seconds after starting the infusion. Intravenous infusion of the same doses of angiotensin induced arterial pres-sure rise of 10 ± 6.6 mmHg and its onset was 68 ± 29.8 seconds. 2. Rise in arterial pressure was associated with initial augmentation of nerve activity in splanchnic and renal nerves. Cardiac nerve activity was not increased. 3. During arterial pressure was maintained at a higher level, a characteristic change in nerve activity was that rhythmical discharges in renal nerve activity disappeared completely and small non-rhythmical activity occurred instead, while the large bursts of discharges in splanchnic nerve activity never disappeared. 4. The pressor response to angiotensin was inhibited by pretreatment with guanethidine, but not with atropin. The results suggest that angiotensin acts on central nervous system to increase central sympathetic outflow in splanchnic nerves, resulting in a rise in arterial pressure.
Putting a Value on Good Governance

This article addresses the following key points: Well-governed companies are outpacing others in investment performance. Investors can reduce risk by underweighting companies with poor governance. Improved governance leads to improved investment performance. Corporate governance indexes are helping investors manage their demand for good governance. The tangible value of good governance isn't always immediate.
New Link in Bioinformatics Services Value Chain: Position, Organization and Business Model

This paper presents development in the bioinformatics services industry value chain, based on cloud computing paradigm. As genome sequencing costs per Megabase exponentially drop, industry needs to adopt. Paper has two parts: theoretical analysis and practical example of Seven Bridges Genomics Company. We are focused on explaining organizational, business and financial aspects of new business model in bioinformatics services, rather than technical side of the problem. In the light of that we present twofold business model fit for core bioinformatics research and Information and Communication Technologie (ICT) support in the new environment, with higher level of capital utilization and better resistance to business risks.
Human freezing in response to affective films

Human freezing has been objectively assessed using a passive picture viewing paradigm as an analog for threat. These results should be replicated for other stimuli in order to determine their stability and generalizability. Affective films are used frequently to elicit affective responses, but it is unknown whether they also elicit freezing-like defense responses. To test whether this is the case, 50 participants watched neutral, pleasant and unpleasant film fragments while standing on a stabilometric platform and wearing a polar band to assess heart rate. Freezing-like responses (indicated by overall reduced body sway and heart rate deceleration) were observed for the unpleasant film only. The unpleasant film also elicited early reduced body sway (1–2 s after stimulus onset). Heart rate and body sway were correlated during the unpleasant film only. The results suggest that ecologically valid stimuli like films are adequate stimuli in evoking defense responses. The results also underscore the importance of including time courses in human experimental research on defense reactions in order to delineate different stages in the defense response.
Comparison of three right-unilateral electroconvulsive therapy montages

The efficacy and cognitive outcomes of electroconvulsive therapy (ECT) on psychiatric disorders have been shown to depend on variations in electrode montages. Conventionally, the right-unilateral (RUL) montage was temporoparietal, originally proposed by d'Elia. Although it was reported to have better cognitive outcomes than the bitemporal montage, it is still associated with substantial memory side effects. Two other RUL montages utilizing a frontal electrode, also proposed by d'Elia, may be more beneficial. In order to investigate this, a high resolution finite element human head model was generated from MRI scans and implemented with tissue heterogeneity. The model was used to compare the effects of three different d'Elia RUL montages. The results suggest that the two alternative placements are likely to result in lesser memory side effects, and may have useful efficacy.
Development and validation of a score to predict postoperative respiratory failure in a multicentre European cohort: A prospective, observational study

BACKGROUND Postoperative respiratory failure (PRF) is the most frequent respiratory complication following surgery. OBJECTIVE The objective of this study was to build a clinically useful predictive model for the development of PRF. DESIGN A prospective observational study of a multicentre cohort. SETTING Sixty-three hospitals across Europe. PATIENTS Patients undergoing any surgical procedure under general or regional anaesthesia during 7-day recruitment periods. MAIN OUTCOME MEASURES Development of PRF within 5 days of surgery. PRF was defined by a partial pressure of oxygen in arterial blood (PaO2) less than 8 kPa or new onset oxyhaemoglobin saturation measured by pulse oximetry (SpO2) less than 90% whilst breathing room air that required conventional oxygen therapy, noninvasive or invasive mechanical ventilation. RESULTS PRF developed in 224 patients (4.2% of the 5384 patients studied). In-hospital mortality [95% confidence interval (95% CI)] was higher in patients who developed PRF [10.3% (6.3 to 14.3) vs. 0.4% (0.2 to 0.6)]. Regression modelling identified a predictive PRF score that includes seven independent risk factors: low preoperative SpO2; at least one preoperative respiratory symptom; preoperative chronic liver disease; history of congestive heart failure; open intrathoracic or upper abdominal surgery; surgical procedure lasting at least 2 h; and emergency surgery. The area under the receiver operating characteristic curve (c-statistic) was 0.82 (95% CI 0.79 to 0.85) and the Hosmer–Lemeshow goodness-of-fit statistic was 7.08 (P = 0.253). CONCLUSION A risk score based on seven objective, easily assessed factors was able to predict which patients would develop PRF. The score could potentially facilitate preoperative risk assessment and management and provide a basis for testing interventions to improve outcomes. The study was registered at ClinicalTrials.gov (identifier NCT01346709).
The polymerase chain reaction for hepatitis B virus DNA

Scan the table of contents of almost any biomedical journal and inevitably you come across articles using the polymerase chain reaction or PCR. In this issue of HEPATOLOCY, two groups (Gerken et al. [ l l and Shindo et al. 121) use PCR to detect DNA from HBV in a variety of patient specimens. These studies demonstrate the analytical power of PCR, as well as its broad applicability to the diagnosis and follow-up of patients with hepatitis B infection. PCR is an elegantly simple method developed in 1985 by scientists at Cetus Corporation (3). Double-stranded DNA containing a target sequence is mixed in a Tris buffer with all four deoxynucleotides, a thermostable DNA polymerase isolated from Thermus aquaticus (so-called Taq polymerase) and at least two oligonucleotides complementary to opposite ends of the two strands of the DNA target sequence. The oligonucleotides (or primers as they are often called) anneal to the appropriate DNA strand, providing a short, doublestranded starting point for Taq polymerase to add nucleotides to the primer and copy the complementary strand. Primer binding sites are typically 100 to 500 bases apart but can be separated by as many as several thousand bases (4). PCR begins with denaturation of the double-stranded target by a brief incubation (30 sec to 2 min) at 92" to 95" C, rapid cooling to 40" to 60" C (1 to 2 mind to allow the primers to bind to the single-stranded DNA target (annealing) followed by heating to 72" C (30 sec to 2 min) for Taq polymerase to elongate the primers. After a single cycle, both original target strands have been copied. The power of PCR comes from repetitive cycles of denaturation, annealing and primer elongation. As each cycle doubles the amount of target DNA, a million-fold amplification can be accomplished by 30 to 35 consecutive cycles. Since the Taq polymerase is stable for extended periods at denaturing temperatures, the entire process can be performed in a closed microfuge tube in an automatically cycling temperature chamber in several hours. After completion of PCR, the sample can be analyzed in a variety of ways. The most common is to electrophorese an aliquot on an agarose gel and after staining with ethidium bromide or another DNA-binding fluorescent dye visualize the amplified material under W
The oxygen isotope relationship between the phosphate and structural carbonate fractions of human bioapatite.

RATIONALE Oxygen isotope analysis of archaeological human dental enamel is widely used as a proxy for the drinking water composition (δ(18)O(DW)) of the individual and thus can be used as an indicator of their childhood place of origin. In this paper we demonstrate the robustness of structural carbonate oxygen isotope values (δ(18)O(C)) in bioapatite to preserve the life signal of human tooth enamel by comparing it with phosphate oxygen isotope values (δ(18)O(P)) derived from the same archaeological human tooth enamel samples. METHODS δ(18)O(C) analysis was undertaken on 51 archaeological tooth enamel samples previously analysed for δ(18)O(P) values and strontium isotopes. δ(18)O(C) values were determined on a GV IsoPrime dual inlet mass spectrometer, following a series of methodological tests to assess: (1) The reaction time needed to ensure complete release of CO(2) from structural carbonate in the enamel; (2) The effect of an early pre-treatment with dilute acetic acid to remove diagenetic carbonate; (3) Analytical error; (4) Intra-tooth variation; and (5) Diagenetic alteration. RESULTS This study establishes a direct relationship between δ(18)O(C) and δ(18)O(P) values from human tooth enamel (δ(18)O(P) = 1.0322 × δ(18)O(C) - 9.6849). We have combined this equation with the drinking water equation of Daux et al. (J. Hum. Evol. 2008, 55, 1138) to allow direct calculation of δ(18)O(DW) values from human bioapatite δ(18)O(C) (δ(18)O(DW) = 1.590 × δ(18)O(C) - 48.634). CONCLUSIONS This is the first comprehensive study of the relationship between the ionic forms of oxygen (phosphate oxygen and structural carbonate) in archaeological human dental enamel. The new equation will allow direct comparison of data produced by the different methods and allow drinking water values to be calculated from structural carbonate data with confidence.
On the Probability of Undetected Error for the Maximum Distance Separable Codes

In this paper we investigate the performance of maximum-distance-separable codes with symbols from GF(q) when they are used for pure error detection or for simultaneous error correction and detection over a q -input and q -output discret memoryless channel with symbol error probability e. First we show that the probability of undetected error for an MDS code used for pure error detection is upper bounded by q^{-r} and decreases monotonically as edecreases from (q - 1)/q to 0, where r is the number of parity-check symbols of the code. Then we show that the probability of undetected error for an MDS code used for correcting t or fewer symbol errors is upper bounded by q^{-r} \Sum\min{i=0}\max{t}(\min{i} \max{n})(q - 1)^{i} and decreases monotonically as e decreases from (q - 1)/q to 0. These results show that the MDS codes are effective for both pure error detection and simultaneous error correction and detection.
Corrosion Detection System for Oil Pipelines Based on Multi-sensor Data Fusion by Improved Simulated Annealing Neural Network

A system to detect the corrosion of submarine oil pipeline is introduced, it got the original data by 3 groups ultrasonic sensors and flux leakage sensors. We made multiscale wavelet transform and frequency analysis to multichannels original data and extracted multi-attribute parameters from time domain and frequency domain, then we selected the key attribute parameters that have bigger correlativity with the corrosion degrees of oil pipeline among of multi-attribute parameters. The improved simulated Annealing artificial neural network was used to do multisensor data fusion to detect the corrosion degrees of submarin oil transportation pipelines and those key attribute parameters were used to as input vectors of network. The experimental results show that this method is feasible and effective.
Modeling Framework for Airport Access Mode Choice Behavior Considering the Effect of Meeters and Greeters

The increasing demand of air traffic together with the construction of an airport city has resulted in growing concern in ground access to Imam Khomeini International Airport (IKIA) in Tehran, Iran. To improve the ground access to IKIA, the government has considered many public transportation options to connect the airport to important locations in Tehran. Based on the effect of Meeters and Greeters (MG) on the access mode choice of air travelers, in this paper a modeling framework is presented that take into account the effect of MGs choice on the overall access mode choice of airports. The proposed framework is applied to the data gathered from IKIA.
Evaluating Analysts’ Value: Evidence from Recommendations around Stock Price Jumps

Recent literature documents that analyst recommendations tend to coincide with important corporate events, but offers mixed evidence on whether such recommendations have added value. In this paper, we use jump in stock price as a proxy for generic corporate “information event” and examine market reactions to recommendation revisions made around such events. Consistent with the literature, we find that analysts revise their recommendations more frequently on days with jumps in stock prices. Although such contemporaneous revisions account for only 10% of the sample, they explain up to a half (a third) of the initial market reactions for downgrades (upgrades). Nevertheless, when focusing on revisions made after stock price jumps - which are less likely influenced by confounding corporate events - we still find that these revisions contain significant price information. The added value is most pronounced for upgrades following positive jumps, with an extra 4.5% average return above those not following jumps over a 6-month horizon.