Miracle-dz/UniFAR-FTUs huggingface dataset:
Omnidirectional Motion Classification With Monostatic Radar System Using Micro-Doppler Signatures

In remote sensing, micro-Doppler signatures are widely used in moving target detection and automatic target recognition. However, since Doppler signatures are easily affected by the moving direction of the target, prior information of aspect angle is essential for spectral analysis. Thus, a micro-Doppler-based classifier is considered to be “angle-sensitive. ” In this article, we propose an angle-insensitive classifier for the omnidirectional classification problem using the monostatic radar through a proposed new convolutional neural network. We further provide a sensible definition of “angle sensitivity,” and perform experiments on two data sets obtained through simulations and measurements. The results demonstrate that the proposed algorithm outperforms both feature-based and existing deep-learning-based counterparts, and resolve the issue of angle sensitivity in micro-Doppler-based classification.
Cost-effectiveness of Itraconazole for the prophylaxis of invasive fungal infections for neutropenic patients; A study for 3 European countries.

Background : Invasive fungal infections present a leading cause of mortality and morbidity in neutropenic patients treated for hematologic malignancies. As the diagnosis and management of invasive fungal infections is difficult, effective antifungal prophylaxis is desirable. Itraconazole is a broad spectrum antifungal agent with activity against Candida species as well as Aspergillus species, whereas fluconazole primarily targets Candida . There is no published data comparing cost-effectiveness of both antifungal agents. Objective : To asses the cost-effectiveness of itraconazole compared with (i) prophylactic fluconazole and with (ii) no prophylaxis in the prevention of invasive fungal infections in Germany, the Netherlands and the UK. Methods : A probabilistic decision model was designed to evaluate the incremental cost-effectiveness of itraconazole versus fluconazole and versus no prophylaxis ( see Figure). Baseline risks for invasive fungal infections and risk reductions for itraconazole (>200mg/day) and fluconazole (400mg/day PO or 200mg/day IV) were taken from studies recently published in two meta-analyses. Costs were evaluated from the health care perspective. Drug acquisition costs for the two prophylactic regimens were calculated using 2003 prices. We estimated the increase in the length of stay as a result of an invasive infection using local or national databases and costed this using reference prices. Results : The meta-analysis revealed that itraconazole is effective in averting invasive fungal disease, in particular aspergillosis. The mean increase in the length of stay for invasive fungal infections was estimated at 9.3 days (rather similar for all 3 countries). As an illustration for our findings: in the Netherlands, itraconazole prophylaxis was expected to be cost-saving compared to fluconazole and provided limited extra costs compared to no prophylaxis at all. Cost-effectiveness was €470 per invasive infection averted for the itraconazole compared to no prophylaxis (95%-CI ranging from cost-saving to €5926 per infection averted). Other country-specific results will be presented at the conference. Discussion & Conclusions : Our study shows that itraconazole prophylaxis is effective and is clinically likely to result in cost-savings or provide an acceptable cost-effectiveness. Itraconazole should be the first choice in the prophylaxis of invasive fungal infections in neutropenic patients with hematologic malignancies, from the clinical and economic point of view.
ANTIBIOTIC RESISTANCE PROFILE OF COMMON UROPATHOGENS IMPLICATED IN URINARY TRACT INFECTIONS IN ROMANIA

Urinary tract infections (UTIs), the second most common type, are a healthcare problem encountered in medical practice, a major cause of morbidity with a high socio-economic impact. The aim of this retrospective study was to identify the most common uropathogens, their susceptibility and resistance to conventional therapies. We analysed the urine samples from 3896 patients and we enrolled 916 cases. Bacterial isolation and antibiotic susceptibility were made using standard methods. From the Gram-negative, E. coli was the most common identified bacteria (42.9%) followed by Klebsiella (21.17%) and Pseudomonas aeruginosa (4.58%). Enterococcus was the most frequent Gram-positive bacteria (18.66%). E. coli strains showed to have an increased resistance to levofloxacin as same as Klebsiella and Enterococcus . The continuous dynamic of uropathogens in different areas and the increasing resistance to conventional antibiotic therapies is a major contemporary health problem. Rezumat Infecțiile de tract urinar (ITU), a doua cauză frecventă de infecții, sunt o problemă des întâlnită în practica medicală, o cauză majoră de morbiditate, cu impact socio-economic puternic. Scopul acestui studiu restrospectiv este de a identifica cei mai frecvenți uropatogeni și de a determina rezistența acestora la tratamentele antibiotice clasice. Au fost analizate 3896 de probe dintre care au fost întregistrate 916 cazuri. Izolarea bacteriilor și sensibilitatea la antibiotic a fost realizată prin metode standard. Dintre bacteriile Gram-negative, E. coli a fost cea mai frecvent identificată bacterie (42,9%), urmată de Klebsiella (21,17%) și Pseudomonas aeruginosa (4,58%). Cea mai frecvent izolată bacterie Gram-pozitivă a fost enterococcul (18,66%). Atât E. coli cât și Klebsiella și enterococcul au prezentat rezistență crescută la levofloxacin. Dinamica permanentă a uropatogenilor în diferite regiuni teritoriale și rezistența în creștere la tratamentele antibiotice este o problemă de sănătate majoră a societății actuale pentru care sunt necesare raportări și actualizări permanente.
Community Detection in Social Networks Using Consensus Clustering

Community detection is one of the most appealing research fields in computer science. Although many different methods have been proposed to cluster the nodes of a graph, none of these methods is complete. Each method has strengths and weaknesses in extracting highly coherent groups of nodes (i.e. communities or clusters). The differences that various methods show are typically due to two main factors: 1) structure of the network they operate on, and 2) the strategy they use to find clusters. Since none of these methods is optimal, it seems a good idea to combine them to take advantage of their strengths while minimizing their weaknesses. In this paper, we present a new approach for the community detection problem by considering an ensemble of community detection methods. We refer to our approach as “Mitra”. The base methods employed in Mitra, use different techniques and strategies to find communities for different applications of network data analysis. Mitra employs some known base community detection methods, receives their results on a network and builds a bipartite network to combine the communities found by the base methods. Then the fast projection technique compresses and summarizes the bipartite network to a new unipartite one. Then we find the communities of the unipartite network in the final step. We evaluate our approach against real and artificial datasets and compare our method with each one of the base methods. Artificial datasets include a diverse collection of large scale benchmark graphs. In this work, the main experimental evaluation function is Normalized Mutual Information (NMI ). We also use several measures to compare the quality and properties of final community structures of the partitions found by all methods.
Complication of lichen sclerosus [Liken sklerozus komplikasyonu]

Lichen sclerosus (LS) is a chronic, inflammatory disease which is mostly located to genital region, usually in women. Etiology of the disease is not exactly understood. It can be asymptomatic or it may also cause itching, scarring or malignity development. Diagnosis of LS is clinical but in some cases, a biopsy may be necessary. The cases who have cellular atypia besides the expected usual findings in the biopsy are considered to be risky for squamous cell carcinoma (SCC) development. Here in this case, the biopsy result from a forty-nine-year-old female patient with a complaint of resistant genital itching and afterwards development of a small tumoral structure has shown SCC findings. We presented this case for taking attentions to the malignity risk on the basis of LS and promoting alertness and early diagnosis.
DEVELOPMENT OF A DISTRIBUTED BIG DATA FUSION ARCHITECTURE FOR MACHINE-TO-MACHINE COMMUNICATION USING ENSEMBLE LEARNING

VIII TABLE OF CONTENTS IX LIST OF FIGURES XIV LIST OF TABLES XVI LIST OF ABBREVIATIONS XVII CHAPTER ONE: INTRODUCTION 1.1 Background of Study 1 1.2 Statement of Problem 3 1.3 Aim and Objectives 4 1.4 Significance of Research 4 1.5 Scope of Study 4 CHAPTER TWO: LITERATURE REVIEW 2.
Allegric Rhinitis: Pearls of Wisdom

Statement of the problem: This provides an overview of Allergic Rhinitis and its management. It is very useful for students of Rhinology and clinicians managing this disease. It introduces them to a systematic approach of assessing allergic rhinitis patients which is very commonly found in most populations and causes considerably morbidity. Allergy per se is a very difficult subject to master and it is with great perseverance one can treat patients suffering from this condition. The cornerstone of managing a patient of allergic rhinitis is first and foremost obtaining a good history. This is to be followed by a thorough examination and investigations. The general practitioner is the first expert to be involved in management of allergic rhinitis patient followed by specialists in particular otorhinolaryngologists, and finally by allied healthcare personnel. Inflammation of nose and paranasal sinuses are characterized by two or more symptoms-namely, eithernasal blockage, obstruction, congestion or nasal discharge. Associated symptoms include facial pain, pressure and either reduction or loss of smell. Certain diagnostic endoscopic signs of nasal polyps and or mucopurulent discharge and or mucosal oedema in the middle meatus and or CT changes of mucosa within the ostoemeatal complex, and or sinuses are seen. Definitions, aetiologies, clinical presentations, diagnosis, prognosis and management of allergic rhinitis is dealt with. Common allergens causing the disease are mentioned, pathophysiology and classification of allergic rhinitis is discussed in detail. Different types of allergen testing are highlighted along with their specific role and uniqueness. Principles of immunotherapy in treatment of allergic rhinitis are discussed here. Health effects of allergic rhinitis along with its impact on physical quality of life is mentioned. The basic idea of this presentation is to improve diagnostic accuracy by promoting appropriate use of ancillary tests like nasoendoscopy, allergy testing, computed tomography etc. and reduce inappropriate antibiotic use. The basic treatment plan of allergic rhinitis is according to the severity and duration. It consists of allergen avoidance, pharmacotherapy, allergen immunotherapy and surgery which has limited role.
Genetic and Epigenetic Modifiers of C9ORF72 Expression in Neurodegenerative Disease

V LIST OF TABLES . IX LIST OF FIGURES . IX CHAPTER 1: INTRODUCTION . 1 Genetics of amyotrophic lateral sclerosis and frontotemporal degeneration . 1 Identification of the C9orf72 repeat expansion mutation. 4 Microsatellite repeat expansions and disease . 4 Loss of function mechanisms of C9orf72 repeat expansions . 7 C9orf72 protein function and autophagy . 9 Gain of function mechanisms of C9orf72 repeat expansions . 11 Intermediate repeat expansions in C9orf72 . 14 Epigenetic alterations in microsatellite repeat expansion diseases . 16 Methods of Epigenetic Editing . 17 DNA methylation and DNA repair pathways . 19 Objectives and Hypotheses . 20 CHAPTER 2: TARGETED DNA METHYLATION OF C9ORF72 VIA ENDOGENOUS DNA REPAIR PATHWAYS . 23 Abstract . 24. 24 Introduction . 25 Methods . 27 Results . 33 Discussion . 42 viii Figures . 44 Supplemental Figures and Tables . 55 CHAPTER 3: C9ORF72 INTERMEDIATE REPEATS AND CORTICOBASAL DEGENERATION . 63 Abstract . 64. 64 Introduction . 65 Materials and Methods . 67 Results . 74 Discussion . 83 Figures . 87 Supplemental Figures and Tables . 99 CHAPTER 4: CONCLUSIONS AND FUTURE DIRECTIONS . 109 DNA methylation is linked to DNA double strand break repair . 109 Hypermethylation of the C9orf72 promoter leads to gene silencing . 111 HARDEN can be applied for targeted methylation of APP . 111 C9orf72 intermediate repeat expansions are a risk factor for corticobasal degeneration . 114 Intermediate length repeat expansions increase C9orf72 expression . 115 Increased C9orf72 expression disrupts autophagy . 116 C9orf72 expression and tau aggregation . 117 Final Remarks . 119 APPENDIX . 120 Protocols . 120 CRISPR gRNA Cloning . 120 DNA methylation detection via MSRE-qPCR . 122 Chromatin immunoprecipitation from cell lines . 123 Feeder Free iPSC culture . 126 Differentiation of iPSCs to NPCs . 127 REFERENCES . 131
CAMPYLOBACTER JEJUNI GASTROENTERITIS COMPLICATED BY SEVERE PANCYTOPENIA IN TWO NORMAL HEALTHY CHILDREN; A VERY RARE PRESENTATION.

Campylobacters are comma-shaped gram-negative bacteria, known to cause mild gastrointestinal illness in form of diarrhea or vomiting. Meningitis, demyelinating encephalomyelitis, Gullian Barre syndrome, endocarditis and osteomyelitis are known to be caused by campylobacter jejuni in immune-compromised individuals. Severe pancytopenia following its mild gastrointestinal infection is very rarely reported in normal healthy individuals. We here report two previously healthy and normal children, who presented with severe pancytopenia following mild campylobacter jejuni gastroenteritis.
Sexual problems among women in the climacteric period in clinical practice

Katedra Zdrowia Kobiety, Wydzia3 Opieki i Oœwiaty Zdrowotnej Œl1skiej Akademii Medycznej; kierownik Katedry: prof. ŒAM dr hab. n. med. Violetta Skrzypulec Okres klimakterium bedzie stanowiae problem cywilizacyjny w XXI wieku, gdy? ok. 1/3 kobiet zamieszkuj1cych kraje wysoko rozwiniete jest w wieku pomenopauzalnym, a ka? da kobieta ponad 1/3 ? ycia prze? ywa po okresie menopauzy. Przekwitanie u kobiet ogniskuje wiele niekorzystnych zjawisk psychologicznych, socjospo3ecznych i biologicznych. Te 3 grupy czynnikow s1 w ro? nym stopniu odpowiedzialne za gorsze funkcjonowanie psychospo3eczne kobiet w okresie oko3omenopauzalnym oraz za znaczny wzrost zaburzen psychologicznych w tym okresie ? ycia. Podejœcie dojrza3ych kobiet do zagadnien dotycz1cych funkcji p3cioOkresowi perimenopauzalnemu czesto towarzysz1 objawy zwi1zane z zaburzeniem stanu psychicznego i aktywnoœci seksualnej kobiet. Za prawid3ow1 reakcje seksualn1 odpowiedzialne jest wspo3dzia3anie hormonow: estrogenow, progesteronu oraz testosteronu. W prawid3owej odpowiedzi seksualnej kobiety wyodrebniono 3 fazy: podniecenia, orgazmu oraz ustepowania podniecenia. W organizmie dojrza3ej kobiety po 40. roku ? ycia obserwuje sie fizjologiczne zmiany ogolnoustrojowe, ktore mog1 negatywnie wp3ywaae na seksualnoœae poprzez zmiane dotychczasowych doznan natury intymnej. Za etiopatogeneze zaburzen seksualnych w okresie oko3omenopauzalnym uznaje sie spadek poziomu hormonow, g3ownie estrogenow i androgenow, przewlek3e choroby ogolnoustrojowe, schorzenia uroginekologiczne, neurologiczne, jak i za? ywane leki. Zgodnie z klasyfikacj1 Amerykanskiego Towarzystwa Psychiatrycznego (DSM-IV), do typowych zaburzen seksualnych u kobiet w okresie perimenopauzalnym zalicza sie zaburzenia po? 1dania seksualnego, podniecenia seksualnego, zaburzenia orgazmu oraz zaburzenia seksualne zwi1zane z bolem. W zakres prawid3owo przeprowadzonej diagnostyki dysfunkcji seksualnych wchodzi badanie podmiotowe (wywiad), przedmiotowe pacjentki (fizykalne i ginekologiczne) oraz badania dodatkowe. Zgodnie ze standardami Kanadyjskiego Towarzystwa Menopauzy, w leczeniu zaburzen seksualnych stosuje sie metody hormonalne i niehormonalne. Do farmakoterapii hormonalnej zalicza sie hormonaln1 terapie zastepcz1 oraz hormonaln1 terapie zastepcz1 ze wstawk1 androgenn1. Leczenie niehormonalne stanowi1: ma3e dawki lekow przeciwdepresyjnych, selektywne inhibitory wychwytu serotoniny, utrzymywanie regularnej aktywnoœci seksualnej, metody treningowe – masturbacyjne oraz psychoterapie indywidualn1, partnersk1, grupow1.
Asset Return Determinants : risk Factors, Asymmetry and Horizon consideration

Les determinants du rendement des actifs demeurent un sujet de recherche actif dans la litterature financiere. Cette these s’interesse au role de certains facteurs de risque, de l’asymetrie de la distribution des rendements et de l’horizon d’investissement comme determinants des rendements d’actifs. Nous demontrons d’abord que l’effet de taille peut etre considere comme etant partiellement le fait de certains secteurs industriels juges statistiquement pertinents pour expliquer specifiquement la performance des portefeuilles constitues d’entreprises de petites (grandes) tailles puis nous en etudions les implications empiriques sur les modeles d’evaluation des actifs. Nous considerons, dans un deuxieme temps, la relation entre le marche et les principaux facteurs de risque proposes dans la litterature – dont le facteur SMB qui prend explicitement en compte l’effet de taille – et soulignons que les facteurs consideres peuvent etre partiellement expliques par le facteur de marche de maniere non-lineaire. En outre, nous montrons que l’exploitation de la relation non-lineaire entre le marche et ces facteurs de risque peut etre profitable en termes de strategies d’investissement. La derniere partie de cette these s’interesse a la question de la diversification temporelle et analyse l’impact de l’horizon sur lesproprietes de la distribution des rendements composes pour montrer que l’effet de composition est la raison principale de la forme des distributions de rendement a long terme. Nous apportons alors un nouvel eclairage permettant d’expliquer les divergences d’opinions exprimees dans la litterature quant aux strategies de placement a suivre sur le long terme.
Effects of Dietary Supplementation with Red Algae Powder (Chondrus crispus) on Growth Performance, Carcass Traits, Lymphoid Organ Weights and Intestinal pH in Broilers

ABSTRACT The aim of this study was to determine the effects of dietary supplementation with red algae powder (Chondrus crispus) on the growth performance, carcass traits, lymphoid organ weights and intestinal pH y in broiler chickens. A total of 300 1-day-old B34 line male broiler chickens were randomly allotted to three treatments, four replicates per treatment and 25 birds per replicate. The experimental treatments consisted of a basal diet (T0) and dietary supplementation of 0.30 (T2) and 0.40% (T2) red algae powder. Body weight at 1, 21 and 32 days did not show significant differences (p>0.05) among treatments. At 21 days, T1decreased (p 0.05) with the red algae supplementation. The dietary supplementation of 0.30% red algae improved the growth performance (at 21-day-old) and some edible parts; also, the dietary supplementation of 0.40% increased the relative weight of the lymphoid organs, without changing the intestinal pH of broilers.
Characteristics, determinants and cost implications of severe adverse drug reactions in the intensive coronary care unit of a hospital

Background: The objective of the study was to determine the predictors, frequency, characteristics and incremental costs of severe Adverse Drug Reactions in the Intensive Coronary Care Unit (ICCU) of a hospital. Methods: Two trained physicians prospectively reviewed case records of all in-patients admitted to ICCU over one year (July 2015 to June 2016) and identified ADRs. Each ADR was assessed for causality, severity, predictability and preventability. Determinants of severe ADRs were identified using multiple binary logistic regression analysis. Cost of severe ADR was estimated based on the corrected duration of excess hospital stay after adjusting for age, gender, co-morbid conditions and number of drugs. Results: Of 573 cases admitted during one year, 47 (8%) patients had 56 severe ADRs. Streptokinase (16.1%) was the commonest drug associated with severe ADRs. Arrhythmias (30.4%) were the commonest severe ADR. Presence of arrhythmias (OR 4.54, 95% CI 2.25–9.14), renal dysfunction (OR 2.27, 95% CI 1.01–5.11) and poly-pharmacy (>10 drugs) (OR 1.13, 95% CI 1.007- 1.254) were found to be the predictors for occurrence of severe ADRs. Majority of severe ADRs were found to be probable 30 (53.6%). 46 (82%) were predictable and 25 (44.6%) probably preventable severe ADRs. Patients with severe ADRs had a longer duration of ICCU (0.8 extra day) and hospital stay (1.5 extra days) (adjusted analysis). The mean incremental cost incurred by patients in the severe ADR group was $ 32 (INR 2170/-) per patient based on the corrected duration of hospital stay. Conclusions: Severe ADRs in ICCU add considerably to treatment costs. Cardiac arrhythmias, renal dysfunction, and polypharmacy are important predictors of severe ADRs.
Informe bibliográfico sobre la lógica (epistémica) de la conciencia

Awareness Logic is an extension of epistemic logic that solves the problem of logical omniscience by incorporating an awareness operator that separates the explicit knowledge from the implicit one. This report collects the most prominent works regarding the beginnings of this logic, as well as its developments in the past three decades. Specifically, it reviews the approaches from Dynamic Epistemic Logic, from the ones that combine other logics with Awareness Logic and those from Game Theory.
Head and neck cancer : an evidence-based team approach

This book deals with the contemporary management of head and neck cancer. It is a useful addition to the field as it is clearly and concisely written and well illustrated. It is aimed at providing surgeons and oncologists who practise in this field with an evidence-based guide to the subject. Experienced clinicians will, I am sure, find this a useful review, while it will offer trainees a good overview for examination revision and for reference while training. It is written in a traditional style with chapters on individual tumour sites. The emphasis on management is very surgical although each chapter has information on the role of radiotherapy and, where appropriate, chemoradiothera-py. The details of chemotherapy are very brief and there is only passing reference to targeted therapy with eGFR receptor antagonists. At the end of each chapter there is inclusion of some case studies. These usually represent case histories from a range of presentations at different stages for that tumour site; the different treatment options are discussed and the decision-making process is outlined. All sites and subsites are covered and there are chapters on ‘the unknown primary’ and ‘carcinomas of the skin of the head, face and neck’. There is also a chapter on surveillance of the patient. This details regular post-treatment cross-sectional imaging and the routine use of follow up PET-CT, which is at variance to standard UK practice. However, it is informative and the case studies included with this chapter demonstrate some false positive investigations that can occur with this imaging modality. All the chapters are well referenced. There are numerous photographic illustrations, which are generally relevant and of good quality. There are several line diagrams; these are of mixed quality and there are some errors and omissions in their placement and annotation. There is also an index that is comprehensive and accurate. In summary, this book gives a good overview of current head and neck cancer management that will provide useful revision for experienced and junior clinicians alike.