Miracle-dz/UniFAR-FTUs huggingface dataset:
Activity Coefficients of Fission Products in Highly Salinary Solutions of Na+, K+, Mg2+, Ca2+, Cl–, and SO42–: Cs+

Binary and ternary interaction parameters of the Pitzer formalism for the thermodynamic modeling of the fission product Cs+ in concentrated salt solutions of the hexary oceanic system Na–K–Mg–Ca–Cl–SO4–H2O at 25 °C were calculated from experimental isopiestic, potentiometric, and solubility data available in the literature. The obtained parameters were checked by comparing measured and predicted water activities and solubilities for binary, ternary, and quaternary systems.
A novel cucumber albino mutant caused by chloroplast development deficiency

Background Photosynthesis is a fundamental process for plant growth and development dependent on a precise network, including formation of chloroplast and chlorophyll synthesis. Chloroplast development deficiency could lead to albinism in higher plant. Results Here, we report a cucumber albino recessive mutant that processed white cotyledons under light condition and is unable to produce first true leaf. Meanwhile, albino mutant could grow out creamy green cotyledons under dark condition but died after exposing to light. Using fluorescence microscopy and transmission electron microscope (TEM), impaired chloroplasts were observed. We identified 7 and 3 differentially expressed genes (DEG) involved in Chlorophyll metabolism and Methylerythritol 4-phosphate (MEP) pathway through transcriptome analysis, respectively. We also examined the reported homologous genes for albino mutants from other plants. Two of 12 genes, TOC159 and DXS1, were up-regulated in cucumber albino mutants as well. The reliability of RNA sequencing results were further confirmed by real-time quantitative PCR (qPCR). Conclusions Taken together, we elaborate the differences between albino mutant and normal seedlings from a single cucumber progeny. This mutant is a new material to study protoplast development.
Grammar in Low-Stakes, Informal Testing Context — Do Different Task Types Influence Performance?

Grammar has always played an important role in foreign language teaching, learning and testing theories and practices. The phenomena of grammatical competence and performance, as well as the ways in what they are assessed in both highand low-stakes contexts are extensively investigated. The present study explores the potential of informal, low-stakes, grammar-based test forms, by adopting a combination of qualitative and quantitative approach. The answers provided by a group of 66 undergraduate B2 students were collected and analysed, through a prism of three different grammar task types focusing on the same grammatical items. The main findings of the study not only revealed some strengths and weaknesses in demonstrating grammatical competence accordingly but also pointed to some links between task types and performance. In the ambience where high-stakes testing is dominant, the study provides a contextualised, diagnostic view of testing grammar and contributes to the understanding of students’ grammar competence and the ways how to assess it.
Modelling a wide range of signals of different distributions by non-iterative functions

In this article, we propose a modeling of a wide range of noise of different distributions by non-iterative functions. All these functions belong to the same family. We can cite some noise distributions chosen from the long series of modeled noises: uniform distribution, Gaussian, Marcheko-Pastur, Wigner, etc. In the literature and in certain cases, the distributions cited above have been obtained from certain measurements or from random matrices. It is possible to construct a non-iterative function which has the same histogram ‘H’ as the histogram ‘H’ produced by a given process.
Targeted nutrigenomics as a means of breast cancer management: from DNA methylation to microRNAs

Breast Cancer (BC) is the most prevalent cancer affecting females and the leading cause of death around the world. The World Health Organization (WHO) has announced that the incidence of BC increases approximately 1.8-2 % annually. Hence, it is important that new prevention and treatment strategies involving epigenetics and nutrigenomics are explored. Epigenetics refers to potential changes in gene expression and chromatin structure without alteration of DNA sequence, but still modulates the expression of a particular phenotype. Nutrigenomics determines the effect of dietary habits on cancer risk and tumor behavior, both in progression and inhibition of cancer. The modulation of chromatin structure is an essential component in the regulation of transcriptional activation and repression. Therefore, identifying the regulators of gene expression changes during cancer progression is essential for early diagnosis and inhibition of this malignancy. The methylation of promoter genes, as well as the interplay between microRNAs (miRNAs) and messenger RNAs (mRNAs) of target genes, is the primary component of epigenetics. Any defect in these processes is considered a crucial mechanism for gene and pathway dysregulation in all human cancers, including BC. Nutritional genomic and epigenetic mechanisms may play a pivotal role in prevention as well as early diagnosis of BC, especially for closely related female family members of BC patients. It seems cytosine methylation in Cytosine-phosphate-Guanine dinucleotide (CpG) Islands reflects changes in balance tissues rigidity. Hypo- and hypermethylation of CpG Islands (CGIs) play a crucial role in development of BC via up-regulation of oncogenes and down-regulation of tumor suppressor genes (TSGs). These could be the most effective mechanisms to distinguish BC from other types of cancer. beneficial effects of some nutritional components on the function and structure of non-coding RNA and DNA methylation. We also discuss the role of nutrigenomics as a non-invasive method to explore the epigenetic mechanisms involved in BC and also in the prevention, treatment, early diagnosis, and distinguishing a variety of cancers from each other. In addition, the importance of non-coding RNAs, including miRNAs in body fluids, also need to be further clarified.
Evaluation of the relationship between MAOA-uVNTR gene polymorphism and impulsivity, anger, temperament and personality traits in healthy male subjects

Aim: Serotonergic activity in the central nervous system negatively correlates with personality traits associated with aggression, impulsivity and anger. MAOA is involved in the catabolism of serotonin and norepinephrine, so the gene encoding MAOA is a candidate gene for aggression-related behavior. It is thought that MAOA genetic variants affect the MAOA activity at different degrees, leading to behavioral changes as a result of a decrease in enzyme activity. The aim of this study is investigating the possible relationship between the MAOA-uVNTR polymorphism genotypes and aggression, anger, impulsivity, temperament-character traits in healthy male subjects. Materials and Methods: 101 Turkish healthy male subjects were included in the study. The participants were given scales to evaluate impulsivity, temperament and character traits, anger and aggression levels. MAOA-uVNTR polymorphism was examined with a sample taken from peripheral blood. Results: A total of 101 people, 33.6% had low-activity allele and 66.4% had high-activity allele of MAOA gene. There was no significant relationship between the temperament-character traits of the participants and MAOA-uVNTR polymorphism. Impulsivity scales were higher in the low-activity allele group, which was statistically significant in terms of motor impulsivity (p = 0.007), non-planning impulsivity (p = 0.031) and total scores (p = 0.029). Conclusion: The low-activity allele of MAOA gene may be a marker for impulsivity. This requires both repetitive studies with healthy controls in the Turkish population and studies in different cultures.
Comparison of health-related quality of life with different antitumor agents for advanced soft tissue sarcoma

Background During cancer treatment, maintenance and improvement of quality of life (QOL) are important, as is prolongation of overall survival. As the disease progresses, patients may experience a decline in QOL due to physical or mental changes. However, few studies have evaluated QOL longitudinally in advanced soft tissue sarcoma (STS) patients according to the antitumor agent. The purpose of this study was to compare health-related QOL (HRQOL) in patients with advanced STS receiving the combination regimen of doxorubicin and ifosfamide (AI) or three novel antitumor agents (pazopanib, trabectedin, eribulin). Methods Twelve patients diagnosed with advanced STS who started chemotherapy between 2010 and 2017 at our hospital were enrolled. HRQOL was assessed using the European Organization on Research and Treatment of Cancer Quality-of-Life Core Questionnaire-30 (EORTC QLQ-C30) after three cycles of chemotherapy before assessing the effect of treatment. Global health status, a functional scale, and a symptomatic scale were compared for the AI regimen and the three novel antitumor agents. Results The mean global health status score of the patients treated with the AI regimen was significantly different from that of those treated with one of the three novel antitumor agents (37.9 and 56.8, respectively). No significant differences were found in the five functional scores. The nausea and vomiting score was significantly different between the AI regimen and eribulin. The constipation score was significantly higher with the AI regimen, and the diarrhea score was significantly higher with pazopanib. Conclusions Compared to the AI regimen, patients can continue treatment with one of the three innovative antitumor agents while maintaining QOL, even with progressive disease. In particular, of the three innovative antitumor agents compared to the AI regimen, patients treated with pazopanib were able to maintain social activities during treatment. In the second-line and subsequent treatments, we could not clearly show a different effect on maintenance of a better QOL among the three innovative drugs, so additional work in the future is needed. If we clarify which of the three drugs most affects QOL, recommendations can be made regarding treatment selection for the second-line and subsequent treatments.
Cultivo de Scenedesmus actus utilizando como fonte de carbono CO2 resultante da queima do carvão mineral para geração termelétrica

RESUMO – A crescente preocupacao com o aumento na concentracao dos gases de efeito estufa na atmosfera vem impulsionando diversas pesquisas a fim de reduzir os niveis de emissao de CO2. O objetivo do trabalho foi utilizar CO2 presente no gas de combustao, proveniente de termeletrica a carvao, como fonte de carbono no cultivo de Scenedesmus actus LEB 116. A fonte de carbono original do meio de cultivo foi substituida por CO2 (aproximadamente 10% v/v) presente no gas de combustao. Parâmetros cineticos dos cultivos foram avaliados, bem como a fixacao diaria maxima de CO2. As maiores concentracao celular maxima (0,82±0,02 g. L -1 ), produtividade maxima (0,07±<0,01 g. L -
Evaluation of Therapeutic Effect and Mechanism of Traditional Chinese Medicine on Non-Proliferative Diabetic Retinopathy

Objective: To review the therapeutic effect and mechanism of traditional Chinese medicine (TCM) on non-proliferative diabetic retinopathy (NPDR). Methods: Randomized controlled studies (RCTs) on NPDR treatment with TCM was conducted by searching China National Knowledge Internet, Wanfang Database, Chinese Biomedical Literature Database, PubMed, EMBASE, Cochrane database. The search date was up to December 24, 2019. At the same time, the mechanism of NPDR with TCM include studies was conducted by searching China National Knowledge Internet, Wanfang Database, PubMed.Results: 3208 related literatures were retrieved and 36 RCTs were included, including 3691 patients. The overall curative effect was significant [n = 4028, RR 1.20 (1.16, 1.25), P < 0.00001, I2 = 35%] with Qiming granule, Compound Xueshuantong capsule, no matter treated with TCM alone or combined with chemical drugs, it could show significant advantages. At the same time, TCM can effectively improve the fundus, and vision, reduce macular thickness, and microangioma of NPDR patients. TCM can reduce the generation of vascular endothelial growth factor and improve the blood retinal barrier through polyol pathway, oxidative stress pathway, etc.Conclusion: Our study shows that TCM has a significant effect on NPDR, and can significantly improve vision, reduce microangioma and macular thickness, and is safe. TCM mainly protects retinal neurons and blood retinal barrier through polyol pathway, which suggests that TCM can prevent macular edema and neovascularization in NPDR patients. However, in consideration of the quality of literature, the results of this study should be carefully considered.
Comparative Study on the Inhibition of Acetylcholinesterase Activity by Hyptis marrubioides, Hyptis pectinata, and Hyptis suaveolens Methanolic Extracts

The inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, may be considered as one of the treatment approaches against several neurological disorders including Alzheimer’s. The purpose of this study is to evaluate, compare, and discuss the anti-acetylcholinesterase activity of three methanolics extracts from Hyptis leaves: Hyptis marrubioides (Hm), Hyptis pectinate (Hp), and Hyptis suaveolens (Hs). AChE activity was measured using a modified 96-well microplate assay based on Ellman’s method. IC50 (half maximal inhibitory concentration) values were calculated for Hm, Hp, and Hs methanolic extracts using physostigmine as a positive control. All the extracts exhibited a dose-dependent AChE percent inhibition with IC50 values lower for Hm, followed by Hp and Hs. Several polyphenols (such as flavonoids and phenolic acids) have been considered a prominent source of anti-Alzheimer disease compounds because of their potential AChE inhibitory activity allied to their well-known antioxidant activity and low toxicity. The results obtained are discussed under the light of the available literature regarding the phytochemical composition and antioxidant activity of Hyptis spp. extracts. Further studies are warranted regarding the role of these Hyptis extracts in the progression of neurological disorders.
Persimmon Flour Co-Products as Novel Ingredients in the Reformulation of Pork Liver Pâté

Co-products from the agro-food industry can be used as novel and natural ingredients in the reformulation of traditional foods to reduce the use of synthetic additives or improve their final quality. The aim of this study was to enrich pork liver pâté with persimmon flour co-products at two concentrations (3% and 6%) and to compare their total cholesterol (high-performance liquid chromatography (HPLC)), fatty acid (Gas Chromatography (GC)) phenolic compound (HPLC) profiles, and lipid oxidation (thiobarbituric acid-reactive substance (TBARS) assay) after in vitro digestion (INFOGEST consensus method) with the control pâté. The cholesterol content in pâté samples was significantly reduced in a dose-dependent way (control > pâté 3% > pâté 6%; 98 ± 8; 89 ± 3; 68 ± 11 mg/100 g pâté, respectively), probably due to the fiber and cholesterol interactions. Gallic, caffeic acids, glycosylated gallic acid, glycosylated coumaric acid, and glycosylated quercetin were detected in the enriched pâtés. The sum of all these compounds was 74 and 239 µg/g pâté in the pâtés with 3% and 6% of persimmon flour, respectively. Oleic, palmitic, and linoleic acids were the majority of fatty acids found in all pâtés. The increase of lipid oxidation after in vitro digestion was higher in the control pâté than in the enriched pâtés. In conclusion, the enrichment of pâté with persimmon flours caused a reduction in their total cholesterol content and lipid oxidation after in vitro digestion, without modifications in their fatty acid profile to what the phenolic compounds could be contributing.
Role of Antioxidant in Testicular Integrity

Spermatogenesis is an extremely active replicative process capable of generating approximately 1000 sperms a second with correspondingly high rates of mitochondrial oxygen consumption by the germinal epithelium. This process generates reactive oxygen species (ROS) through reactions with drugs and environmental toxins, or when the level of antioxidants is diminished results in oxidative stress. Excessive production of free radicals or ROS can damage sperm, testes and can cause serious chemical damage to biomolecules (DNA, proteins, and unsaturated lipids) which ultimately lead to cell death and cause infertility. The cell has several protective mechanisms that minimize the toxic potential of these reactive oxygen species. These include the low oxygen tension in the tissue and also the elaborate array of antioxidant enzymes and free radical scavengers it contains; to ensure that the spermatogenic and steroidogenic functions of this organ are not impacted by oxidative stress.
Rutile Crystallites Isolated from Degussa (Evonik) P25 TiO2: Highly Efficient Photocatalyst for Chemoselective Hydrogenation of Nitroaromatics

We report that the rutile crystallites, isolated from Degussa (Evonik) P25 TiO2 by a hydrofluoric acid treatment, behave as a highly efficient photocatalyst for hydrogenation of nitroaromatics. Photoirradiation (λ >300 nm) of the isolated rutile particles with alcohol as a hydrogen source successfully promotes chemoselective hydrogenation of nitroaromatics to anilines, with an activity higher than that of commercially available rutile TiO2. The high activity of the isolated rutile particles is due to the specific distribution of structural defects (oxygen vacancy sites) on the particles. These particles contain a relatively small number of inner defects behaving as recombination centers for photoformed electron (e–) and positive hole (h+) pairs, and a relatively large number of surface defects behaving as reduction sites for nitroaromatics. Photoexcitation of the isolated particles therefore promotes efficient charge separation between e– and h+, and facilitates rapid reduction of nitroaromatics adsorbed .
Formulation And Evaluation Of Chitosan Microspheres Containing Isoniazid

The present investigation was designed to prepare chitosan microspheres and evaluate the in vitro release pattern of the drug isoniazid. The microspheres were formulated by glutaraldehyde cross-linking method using various concentrations of chitosan. The prepared microspheres were evaluated for drug content, particle size distribution, stability studies and compared with marketed tablets. The percentage of entrapment obtained was 60 %. In vitro release studies were carried out in 0.1 N HCI and 88.1, 83.8, 79.3 and 73.0 % of drug was released from 0.5, 1.0, 1.5 and 2.0 % of chitosan microspheres respectively after 8 h. Stability studies were carried out at different temperatures and found that all the formulations were more stable at 4o and room temperature.
Economics 10x10 – Lessons from the Last Ten Decades of Hungarian Economic History

This paper over­views the eco­nomic his­tory of Hun­gary in the last 100 years, and es­pe­cially the con­ver­gence pro­cess to the ad­vanced eco­nom­ies which was hindered by severe ex­ternal shocks, two world wars, global eco­nomic crises and the sup­pres­sion by the So­viet Union. After the polit­ical trans­ition of 1990, many ex­pec­ted a rapid eco­nomic mir­acle, but the eco­nomic trans­ition period was pro­longed for 20 years. Thus, the sus­tain­able con­ver­gence has star­ted only after 2010 when the ne­ces­sary fiscal, mon­et­ary and struc­tural re­forms were im­ple­men­ted. The most im­port­ant les­son we can draw from our eco­nomic his­tory is that eco­nomic growth can­not be sus­tained without fin­an­cial bal­ance, thus eco­nomic policy has to find the ef­fect­ive and tar­geted meas­ures to en­hance eco­nomic growth and mac­rofin­an­cial bal­ance at the same time.
Effect of high temperature on photosynthetic performance in wheat

The effect of high temperature on photosynthetic and chlorophyll fluorescence characteristics in different wheat varieties(emi-spring wheat cultivar: Huaimai 30, semi-spring wheat cultivar: zhengmai 9023, and semi-winter wheat cultivar: Yannong 19) was studied at the 7th and 15 th day after anthesis. The results showed that after the seedlings were exposed to the high temperature(24℃/ 34℃,night/ day) at the 7th day after anthesis for 3 days, the net photosynthetic rate(Pn), stomata conductance(Gs), maximum quantum yield of PSII(Fv/Fm), photochemical quenching(qP), non-photochemical quenching(qn), and acyclic photosynthetic electron transfer rate of PSII(ETR) of Yannong 19 were significantly higher than those of Huaimai 30 and Zhengmai 9023(P0.05) and the Pn, Ci and Fo of Zhengmai 9023 were significantly higher than those of Huaimai 30, while the intercellular CO2 concentration(Ci) of Yannong 19 was significantly lower than that of Zhengmai 9023 and Huaimai 30. In addition, intercellular CO2 concentration(Ci), photochemical quenching(qP) and non-photochemical quenching(qn) of Huaimai 30 were significantly higher than those of Zhengmai 9023. After exposure to the high temperature(26℃/36℃, night/ day) at the 15 th day after anthesis for 3 days, Pn, Gs, Ci, Fv/Fm, qP, qn and ETR of Yannong 19 were significantly higher than those of Huaimai30 and Zhengmai 9023(P0.05), while Fo of Yannong 19 was significantly lower than that of Huaimai 30 and Zhengmai 9023. In addition, Pn, Gs, Ci, Fv/Fm, qP and EYR of Zhengmai 9023 were significantly higher than those of Yannong 19. However, Fo of Zhengmai 9023 was significantly higher than that of Huaimai 30, and Fo of Huaimai 30 was significantly higher than that of Yannong 19. Therefore, under the high temperature stress at the 7th and 15 th day after anthesis, semi-winter wheat cultivar(Yannong 19) had the highest photosynthetic activity and the best self-protection mechanism, followed by spring wheat cultivar(Huaimai 30), and semi-spring cultivar(Zhengmai 9023).
Simulation interprofessionnelle en visio-conférence

La formation interprofessionnelle a été mise en place à Genève pour répondre aux défis de notre système de santé : amélioration de la qualité des soins et de la sécurité des patients, évolution démographique, évolution des rôles des professionnels de la santé. Ces défis imposent une transformation de l’organisation des soins et de la formation. Le Centre interprofessionnel de simulation (CiS) a été créé pour développer les compétences interprofessionnelles tout au long du continuum des formations prégraduées, postgraduées et continues, en utilisant comme principale modalité pédagogique la simulation [1]. Les formations interprofessionnelles au CiS sont élaborées et dispensées selon une approche par compétences. Elles s’appuient sur des outils d’amélioration de la performance du travail en équipe et de la sécurité des patients, tels que le modèle TeamSTEPPS ® [2]. En formation prégraduée, trois modules interprofessionnels impliquent environ 1500 étudiants de sept filières de formation : médecins, pharmacien-nes, infirmier-es, sages-femmes, technicien-nes en radiologie médicale, diététicien-nes, physiothérapeutes [3]. Parmi ces trois modules, le second s’appuie essentiellement sur des simulations interprofessionnelles. Il s’adresse à des étudiants en milieu de formation (2 année de bachelier pour les soignants et 1–2 demaster pour les médecins). Les buts du module sont notamment, à travers des situations cliniques proches de la réalité professionnelle, de parvenir à une représentation partagée de situations cliniques, de négocier en équipe des objectifs de prise en charge / intervention et d’exercer des techniques de communication.