Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative Modeling of Human P-gp NBD2 and Docking and Binding Mode Analysis of 8-Geranyl Chrysin as a P-gp Modulator

The resistance of tumour cells against cytotoxic drug is significant limitation in successful chemotherapeutic treatment of cancer. To date, no crystal structure is available for human P-gp. We developed homology model for human P-gp NBD2 by using coordinates of transporter associated protein (TAP1). Docking study was performed for 8-geranyl-chrysin (Flavonoids) inhibitor in the NBD2 model. Ligand-protein interactions were determined which indicates that the 8-geranyl chrysin shares two overlapping sites in the cytosolic domains of P-gp, the ATP site and a hydrophobic steroid-binding site.
Effect of Molecular Weight on Electro Spun Pcl Based Composite Fibrous Mats

Electro spinning is commonly utilized for forming nanofibrous scaffolds, to mimic the extra cellular matrix (ECM), for tissue engineering applications. Polycaprolactone (PCL) is often favored for Electrospinning of tissue engineering scaffolds. One of the reasons for its widespread usage is PCL’s ability to degrade in physiological conditions, by hydrolysis of its ester linkages [1], into intermediates such as 6-hydroxylcaproic acid and acetyl coenzyme A, which are eliminated from the body through the citric acid cycle [2]. However, PCL degrades very slowly due to the five hydrophobic CH2 moieties in its repeating units (Figure 1) [3].
An exploratory study of consumer demeanor towards financial investment

Investment is the employment of fund on assets with the aim of earning income or capital appreciation. Investments have become a basic necessity for everyone. In India there is a rapid growth in investment. This is why an understanding of consumer demeanor for financial investment is vital to the success of the business. The review paper covers the various financial avenues like equity/stocks, bank fixed deposits, kisan vikas patra, national savings certificate, life insurance, mutual fund and discusses the factors influencing investment decision process. The prime factors affecting the financial investment behavior are demographic factors and socio-economic factors. They can further be segregated as age, income, qualification, gender, social class, family income, tax benefits, safety of fund, brand perception, risk appetite, past performance, return on investment.
Obstacle Avoidance of Leader-Follower Formation

This paper presents obstacle avoidance of Leader-Follower formation. The follower robot maintain the formation with leader robot and avoid the detected obstacle. When obstacle is detected, follower robot avoid it considering leader robot and follower robot position and follower robot and obstacle position. In addition, follower robot avoid obstacle irrespective of obstacle size. Controller of follower robot is designed to satisfy Lyapunov stability by backstepping method. Simulation results shows that the designed controller has a stable performance.
Financial Deregulation and Crisis:An ‘Agency-conflict’ Case of Japan

The main focus of this paper is on the ‘agency-conflict’ during financial deregulations in the 1980s as the potential causality of Japanese banking crisis in the 1990s. Agency conflict is defined as the conflict of interest among the policy makers and agencies (e.g. banks) that arises as a combined effect of heteroschedasticity1 of policy shifts at that time and the overall weaknesses of corporate governance of the Japanese banks. This paper theoretically and empirically tests the hypothesis that “agency-conflict” increases short-term profit and can be a potential cause of the subsequent crisis. First part of the theoretical model based on the Bayesian Learning Model explains how agency conflict can increase profit in brief and second part of the theory explains how banks can be vulnerable to crisis at the outset of the bubble. Moreover, the theoretical model is used as the basis of empirical analyses on the causes to the probability of banking crisis. The paper also provides discussion on a number of interrelated structural changes and agency-conflicting issues that occurred in the Japanese financial system. However, the analyses find that the ‘agency-conflict’ is significant to the probability of banking crisis.
Test Case Prioritization based on Fault Dependency

Software testers should prioritize test cases so that important ones are run earlier in the regression testing process to reduce the cost of regression testing. Test case prioritization techniques schedule test cases for execution in an order that improves the performance of regression testing. One of the performance goals i.e. the fault detection rate, measures how quickly faults are detected during the testing process. Improved rate of fault dependency detection can provide faster feedback on software and let developers debug the leading faults at first that cause other faults to appear later. Another performance goal i.e. severity detection rate among faults, measures how quickly more severe faults are detected earlier during testing process. Previous studies addressed the second goal, but did not consider dependency among faults. In this paper an algorithm is proposed to prioritize test cases based on rate of severity detection associated with dependent faults. The aim is to detect more severe leading faults earlier with least amount of execution time and to identify the effectiveness of prioritized test case. Index Terms—Software testing, Regression testing, Test case prioritization, Fault dependency, Software quality.
Public Funding and Corporate Innovation

We review and condense the body of literature on the economic returns of public RD (ii) private RD (iii) RD (iv) there appear to exist complementarities between alternative sources of funding; (v) the mobility of RD (vi) there are many university spin-offs but these are no more successful than non-university spin-offs; (vii) universities constitute important collaboration partners and (viii) clusters enhance collaboration, patents and productivity. Key problems for economic policy advice are that the identification of causal effects is problematic in most studies and that little is known about the optimal design of policy measures.
HOT GAS HALOS IN EARLY-TYPE GALAXIES AND ENVIRONMENTS

We investigate the dependence of the extended X-ray emission from the halos of optically luminous early-type galaxies on the small-scale (the nearest neighbor distance) and large-scale (the average density inside the 20 nearest galaxies) environments. We cross-match the 3rd Data Release of the Second XMMNewton Serendipitous Source Catalog (2XMMi-DR3) to a volume-limited sample of the Sloan Digital Sky Survey (SDSS) Data Release 7 with M r X /L r , shows a clear correlation with the distance to the nearest neighbor and with large-scale density environment only where the galaxies in pair interact hydrodynamically with seperations of r p vir . These findings indicate that the galaxies in the high local density region have other mechanisms that are responsible for their halo X-ray luminosities than the current presence of a close encounter, or alternatively, in the high local density region the cooling time of the heated gas halo is longer than the typical time between the subsequent encounters.
Private Consumption in the WAEMU Zone: Does Interest Rate Matter?

This paper investigates the effect of interest rates on private consumption in the West African Economic and Monetary Union (WAEMU). After checking for unit root and co-integration, Error Correction Model is specified, three estimators are performed: Mean Group, Pooled Mean Group and Dynamic Fixed-Effects. Hausman tests indicate that the Dynamic Fixed-Effects estimator is more efficient and consistent than others. Results suggest that, there is no statistical evidence, both in short-run and long-run, impact of real and nominal saving interest rates on private consumption in the WAEMU region, from 2006 to 2014. These finds imply that, neither substitution effect, nor income effect, operate in this zone. However, the paper finds that, the growth of private consumption is strongly depends positively, in the long-run, on the gross national disposable income and the credit to private sector ratio. The long-run income elasticity and semi-elasticity of liquidity constraints are statistically significant and average to 0.92 and 0.0085, respectively. These finds imply that, there is a need for more proper financial market development and financial education policies implementation to have negative and significant impact of interest rates on private consumption in the WAEMU zone.
Development of a Proximal Machine Vision System for off-Season Weed Mapping in Broadacre no-tillage Fallows

Weeds are among the most significant and costly environmental threats in Australian agriculture. Weeds compete with crop plants for moisture, nutrients an d sunlight and can have a detrimental impact on cro p yields and quality if uncontrolled. The distributio n, size, density and species of the weeds are often heterogeneous in the cropping land. Instead of unif ormly spray the same type of herbicide to the whole farm land, selective spray can reduce the herbicide usag e therefore can reduce the serious problems of herb icide resistance, soil damage and food safety. This study describes a weed mapping method which could be used for broadacre no-tillage fallow weed management. The weed maps have the potential to be used as powerf ul herbicide prescription maps for spot spray. The wee d mapping is realized by the machine vision technologies which including image acquisition, ima ge stitching and photomosaic processing. The sampli ng points are continuous and the interpolation methods are used at the minimum levels. The experiment res ult shows that this weed mapping method can map weed under limited conditions.
Effect of initial tangential intensity on the fluid dynamic characteristics in tangential burner

Swirl turbulent flow is intensively used by the industrial equipments such as combustion, separation and heat transfer equipments. The fluid dynamic characteristics of this flow are influenced by the chamber’s geometries and the operating conditions. One of the important operating condition variables which greatly affects the fluid dynamic characteristics is initial tangential intensity (I TI ) or often known as swirl number. This study is aimed to quantify the effect of the initial tangential intensity on the fluid dynamic characteristics in a tangential burner. The method of the study is based on the computational fluid dynamic simulation under the Ansys Fluent CFD engine. The fluid dynamic characteristics were modeled using the standard k-e turbulent model. The simulation results exhibited that the three dimensional flow structure in a tangential burner is dominated by the tangential flow. The fluid dynamic simulations also showed that the effect of the I TI on the mean turbulence intensity and the mean residence time begin to be significant at the I TI values ≥ 1.1 and ≥ 4.5 respectively, while at low I TI values, its effects on both variables are insignificant. The lowest pressure drop obtained in this study was found on the burner with I TI value of 3.2.
Infrared-Triggered Actuators from Graphene-Based Nanocomposites

The emerging field of optical-triggered actuators based on polymeric nanocomposite continues to be the focus of considerable research in recent years because of their scientific and technological significance. In principle, dispersing nanofiller with unique characteristics in polymer matrix can not only provide superb enhancement of performance but also afford novel actuation schemes to the systems. Graphene, combining its unusual electrical, thermal, mechanical, and optical properties, can provide the ability to act as “energy transfer” and trigger unit in the realm of nanocomposite actuators. Herein, we demonstrate a new dimension to this 2D nanoscale material by showing the excellent light-triggered acutation of its thermoplastic polyurethane nanocomposites with significantly enhanced mechanical properties. These nanocomposite actuators with 1 wt % loading of sulfonated functionalized graphene sheets (sulfonated-graphene) exhibit repeatable infrared-triggered actuation performance which can strikingly .
The natural variability of stratospheric and mesospheric ozone as observed over Switzerland by a ground-based microwave remote sensor .

Continuous ground-based microwave observations of the vertical middle atmospheric ozone profile are performed at the Institute of Applied Physics of the University of Berne, Switzerland, since November 1994. The high temporal resolution, associated to the continuity of the achieved datasets, allows a detailed characterization of the natural cycles affecting stratospheric and mesospheric ozone above this midlatitude observation site on a daily to decadal time scale.
Internal customer behavior intention: causality service quality, satisfaction, and internal customer behavior intention in educational services in east java (overview the service marketing triangle)

This study aims to test the causality of internal service quality, internal customer satisfaction, internal customer behavior intention in the context of the internal customers of public service agencies in East Java by using SEM as a statistical test. This study was conducted in East Java with a sample size of 150 respondents. The sample is derived from the internal customers of the 3 best educational services provider in East Java of the 10 best universities in Indonesia in 2013. Based on the results of research and discussion that has been done can be concluded as follows: The first hypothesis in this study stated that the Internal Service Quality Affects the Internal Customer Satisfaction in educational services in East Java, is accepted. The second hypothesis in this study stated that the Internal Customer Satisfaction Affects the Internal Customer Behavior Intention in educational services in East Java, is accepted. The third hypothesis in this study stated that the Internal Service Quality Affects the interest of Internal Customer Behavior through Internal Customer Satisfaction in educational services in East Java, is accepted. Suggestions put forward in this study are: expected that further research will discuss about the internal marketing can consider variables - other variables outside of reviews these variables have been studied in order to more comprehensively obtain results. Organization of education service providers always concerned about the quality of internal services. Because based on the results of this study of internal service quality is a factor that has a significant positive effect on the interest of the internal customer behavior through internal customer satisfaction
Training Direction-Discrimination Sensitivity Remediates a Wide Spectrum of Reading Skills

Background: This study investigated whether timing deficits in the motion pathways represent a core deficit in inefficient readers who are dyslexic. Methods: Inefficient and efficient readers in grades 2 and 3 in four public elementary schools were studied. Component literacy skills were measured before and after training. In the training task of interest, participants judged the direction of motion (left vs. right) of a vertically oriented sinusoidal grating, surrounded by one of five different background frequencies. The threshold contrast for direction discrimination was measured. Results: Direction discrimination improved the most for inefficient readers following training. Moreover, following training the time to complete the task decreased significantly, showing that the timing of direction discrimination improves, as does the gain. For inefficient readers, training on direction discrimination resulted in significant improvements in reading efficiency and fluency. Inefficient readers in control conditions showed minimal improvement. Conclusions: Significant improvements in reading performance were found following training on direction discrimination. This study provides evidence that timing deficits in inefficient readers represent a core deficit.
An Additive Branch-and-Bound Algorithm for the Pickup and Delivery Traveling Salesman Problem with LIFO Loading

This paper introduces an additive branch-and-bound algorithm for a variant of the pickup and delivery traveling salesman problem in which loading and unloading operations have to be performed in a Last-In-First-Out (LIFO) order. Two relaxations are used within the additive approach: the assignment problem and the shortest spanning r- arborescence problem. The quality of the lower bounds is further improved by a set of elimination rules applied at each node of the search tree to remove from the problem arcs that cannot belong to feasible solutions because of precedence relationships. The performance of the algorithm and the effectiveness of the elimination rules are assessed on instances from the literature.
Strategic control of postharvest decay in peach caused by Monilinia fructicola and Colletotrichum gloeosporioides

In this work we report the postharvest control of Monilinia fructicola - causative agents of brown rot and Colletotrichum gloesporioides - causative agents of anthracnose. These fungi contribute significantly to the reduction of the marketing period of peach. The conventional control of these diseases can leave chemical residues on fruits and selecting resistant pathogenic strains. The use of essential oils can be a more appropriate alternative. Essential oil of Eucalyptus globulus, Cinnamomum camphora and Cymbopogum citratus were used in control. The results have demonstrated good control of these diseases manly using C. camphora and C. citratus in vitro and in vivo analysis beyond in vivo simulating cold storage. Our results in these essays indicate the possibility of using environmental-friendly essential oil in postharvest control of peaches and others fruits, without utilization of chemical fungicides.
4. EFFECT OF ASSIMILATION OF ALTERED OCEANIC CRUST ON MAGMA CHEMISTRY: AN EXPERIMENTAL STUDY1

Altered basalt dikes from Hole 504B were partially melted at 1150°C and 1180°C to determine the composition of the first melts as oceanic Layer 2C is assimilated by a magma chamber. The partial melts are chemically similar to actinolite, the most abundant secondary mineral, but the melts are not simply melted actinolite. High TiO2, P2θ5, and K2O abundances of the melts indicate that minor secondary minerals that are enriched in these elements also contribute to the melt. The incorporation of partial melts into a ridge-crest magma chamber may explain the local variability that is sometimes found in ocean ridge basalts that are not readily explained fractional crystallization or partial melting.
Nutrient use efficiencies and leaching of organic and conventional cropping systems in Sweden

Organic farming has been proposed as a means of reducing leaching and improving the use efficiency of plant nutrients in agriculture. In such systems, nutrient inputs originate from various organic sources or from naturally occurring minerals with low solubility. In this study, measurements of leaching and crop uptake of N, P, and K and determinations of mineral N in soil were conducted in tile-drained plots during a 6-yr period in two organic crop rotations, one with and one without addition of animal manures. In the latter, N was provided by green manures. For comparison, two conventional systems in which mineral fertilizers and pesticides were used (one with cover crops) were also included. Leaching loads of N were smallest in the conventional system with cover crops, on average 25 kg N ha -1 yr -1 over the 6-yr period. The corresponding amounts in the other systems were 39 (organic with animal manure), 34 (organic without animal manure), and 38 (conventional) kg N ha -1 . Phosphorus-leaching loads were small overall in all systems (<0.25 kg ha -1 yr -1 ). Potassium-leaching loads reached on average 27 kg ha -1 yr -1 over the 6 yr in the conventional systems and 16 kg ha yr -1 in the organic systems. When N leaching was expressed as a percentage of total N removal during the 6-yr period (leaching plus harvested N with crops), it represented 59% in the organic system without animal manure, 33% in the conventional system, and 22% in the conventional system with cover crops. These results clearly suggest that N use efficiency is improved if inorganic N fertilizers are used rather than green manures, especially in combination with cover crops. The superior system from all considerations was the conventional system with a cover crop.
Why boys achieve less at school than girls: the difference between boys' and girls' academic culture

Recently, research into gender differences in achievement has mainly concentrated on the underperformance of boys in comparison with girls. Qualitative research in particular points to the importance of the gender-specific cultures adolescents experience. The purpose of this article is to test quantitatively the explanatory value of academic culture with respect to the stated gender differences in achievement. Use is made of data of 3760 pupils in the third and the fourth year of secondary education in a sample of 34 schools in Flanders (Belgium). A distinction is made between general schools preparing students for higher education and schools offering technical and vocational education. It is demonstrated that boys' culture is less study oriented than girls' culture and that this difference can be held responsible for the gender differences in achievement, at least in general schools. In technical/vocational schools, boys seem to oppose the study culture.
Prevalence of subclinical hypocalcaemia and subclinical ketosis in buffaloes.

The present study was undertaken to study the prevalence of subclinical hypocalcaemia and subclinical ketosis in buffaloes. Out of 166 buffaloes screened, 61 (36.75%) and 42 (25.30%) buffaloes were found to be positive for SCH and SCK, respectively. Month wise analysis revealed higher prevalence of SCH and SCK in October and November, respectively (i.e., rainy season and winter season) while the lowest was recorded in the months of May and June for SCH and for SCK (i.e. April, May and June: the summer season). Lactation wise highest prevalence was recorded in third and fourth lactations for SCH and SCK respectively, while buffaloes in fi rst parity were least affected by the two conditions. The prevalence of both conditions was higher in organised dairy farms than the unorganised dairy units. Of the diagnostic tests utilised for SCH, estimation of serum calcium levels was found superior to the Sulkowitch test while for SCK, estimation of blood ketones was found superior to Rothera’s test and the urine dip stick test.
Particle Swarm Optimization Combining Diversification and Intensification for Nonlinear Integer Programming Problems

In this research, focusing on nonlinear integer programming problems, we propose an approximate solution method based on particle swarm optimization proposed by Kennedy et al. And we developed a new particle swarm optimization method which is applicable to discrete optimization problems by incoporating a new method for generating initial search points, the rounding of values obtained by the move scheme and the revision of move methods. Furthermore, we showed the efficiency of the proposed particle swarm optimization method by comparing it with an existing method through the application of them into the numerical examples. Moreover we expanded revised particle swarm optimization method for application to nonlinear integer programming problems and showed more effeciency than genetic algorithm. However, variance of the solutions obtained by the PSO method is large and accuracy is not so high. Thus, we consider improvement of accuracy introducing diversification and intensification.