Miracle-dz/UniFAR-FTUs huggingface dataset:
Oral quercetin supplementation and blood oxidative stress during ultra‐marathon competition

Previous research indicates that prolonged exercise results in blood oxidative stress. We investigated the efficacy of oral quercetin supplementation, a naturally occurring compound with known antioxidant properties, as a potential countermeasure against blood oxidative stress during an ultra‐marathon competition. In double blind fashion, 63 subjects received either oral quercetin (250 mg, 4x/day; 1000 mg/day total) or placebo 3‐weeks prior to and during the Western States 100 mile trail run. Blood drawn before and immediately following (quercetin finishers n=18, placebo finishers n=21) the event was analyzed for changes in blood redox status and oxidative damage. Results show that in response to the ultra‐marathon challenge, aqueous phase antioxidant capacity (ferric reducing ability of plasma, FRAP) was similarly elevated in athletes from both quercetin and placebo treatments and likely reflects significant increases in plasma urate levels. Alternately, trolox equivalent antioxidant capacity (TEAC) was not altered by exercise or quercetin based on a significance level of p < 0.05. Accordingly, neither F2‐isoprostances nor lipid hydroperoxides were influenced by either exercise or quercetin supplementation. These findings indicate that oral quercetin supplementation does not appear to alter the lipid or aqueous phase antioxidant capacity of the blood plasma during an ultra‐marathon challenge.
In utero and postpartum exposure to long chain n‐3 polyunsaturated fatty acids improves intestinal glucose absorption and glycogen stores in weanling pig

The objective of this study was to determine whether in utero and postnatal exposure of long chain n3‐PUFA would alter glucose absorption from the proximal jejunum or muscle (longissimus dorsi) glycogen concentrations in piglets at weaning. Dams were fed one of three experimental diets for 150 days prior to farrowing: 1) corn/soybean meal control; 2) As 1 + protected fish oil, (PFO, JBS United Inc.) or, 3) As 1 + algal cells high in docosahexaenoic acid (DHA, ABN Corp.). Treatments 2 and 3 were formulated to the same level of DHA. All tissues were collected from piglets weaned and fasted for 24 h (n=4/trt). Jejunum and muscle samples were analysed for fatty acid profiles which reflected the dam's dietary and milk fatty acid profile. Proximal jejunum samples were mounted in modified Ussing chambers. Piglets from treatments 2 and 3 displayed increased (P<.05) active glucose transport (133 and 420%, respectively) compared to treatment 1. The improvement in glucose uptake associated with trts 2 and 3 coincided with increased (P<.05) GLUT2 and SGLT1 protein expression. However, muscle glycogen was increased (P<.05) only in piglets from dams allotted to trt 3 (46 vs 34 mg/g wet tissue, for trts 1 and 3, respectively). These results indicate that the absorption and storage of glucose may be enhanced by in utero and neonatal exposure to long chain n3‐PUFA such as DHA.
The 2018 Nobel Prize in Medicine for breakthroughs in targeting immune checkpoint inhibitors: a brief perspective

Institute, Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. Email: Adan.Rios@uth.tmc. edu or Zhiqiang An. Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. Email: Zhiqiang.An@uth.tmc. edu
Relations of Enteromorpha prolifera blooms with temperature,salinity,dissolved oxygen and pH in the Southern Yellow Sea

In March-June 2010,five cruises were conducted at "hot spots" for Enteromorpha prolifera bloom in the Southern Yellow Sea to study the importance of environmental factors in the outbreak of green tide.Waters in the investigated area were observed to have a low salinity and high nutrients due to the terrestrial runoff and northern Jiangsu coastal current.These characteristics may result in the frequent outbreak of green tide in this area.Water temperature increased gradually from 8.8℃ to 21.6℃ during the five cruises.During the third cruise(average temperature,14.6℃;average salinity,31.6),floating Enteromorpha prolifera mats were observed at the survey area.Temperature and salinity during 3-5cruises were found to be suitable for the growth and spore release of Enteromorpha prolifera.DO was over-saturated at most sampling stations and it decreased gradually from cruise 1to 5.pH was found to be less than 8.0at almost the entire survey area due to the terrestrial input.Results of this study implied that temperature,salinity,pH and DO could be the factors that enhance the growth and spore release of Enteromorpha prolifera,subsequently promoting the occurrence of green tide in the southern Yellow Sea.
Gut fill revisited.

Generally, a dairy cow’s daily dry matter intake (DMI) will be under the influence of the physical capacity of the rumen. This is known as gut fill. As demonstrated by several research groups, the undigested NDF pool is related to gut filling effect of a ration. Specifically, it is suggested that NDFu30, i.e., the undigested NDF pool remaining after 30 hr of in vitro rumen incubation, is an appropriate proxy for gut fill. The proposed gut fill index for a ration is pounds of NDFu30 supplied from forages and other products that are larger than 4 mm. Monitoring a ration’s gut fill index will assist in identifying ration changes that may impact DMI. However, rumen environments which change overall fiber digestibility will bias the gut fill index. Under higher acid conditions, fiber digestibility will be compromised, leading to a falsely lower gut fill capacity. Rations with low particle size will result in increased passage rates, leading to a falsely higher gut fill capacity. In general, corn silage will have the lowest NDFu30 pool size of forages, with most grasses having NDFu30 pools size approximately 35% larger. NDFu30 is meant to be an indicator of gut fill that is appropriate for evaluating forages as well as, the gut fill load for a ration’s forage base. Introduction
The Relationship between Glutathione S-transferase M1 and Susceptibility to Xuanwei's Lung Cancer

Objective To investigate the relationship between GSTM1genetic polymorphism and lung cancer susceptibility in Xuanwei,China.Method In a case-control study,PCR and RFLP was used to identify the genotypes of GSTM1 in 50 lung cancer cases and 50 controls.Results GSTM1 polymorphism showed frequency distribution differences,OR=2.71(1.20～6.11). There was a significant difference between the case group and the control group(P0.05). Using bituminous coal was strongly associated with the risk of lung cancer(OR=3.78,P0.01). People using bituminous coal with GSTM1(-/-)genotype had an odds ratio of lung cancer compared with people not using bituminous coal with GSTM1(+/+)genotype(OR=9.23(2.24～38.29,and there was a significant difference(P0.01). Conclusions GSTM1 null genotype increases the risk of lung cancer,Persons using bituminous coal with GSTM1 null genotype have higher risk of lung cancer.
Effect of prometryne on root activity and oxidative stress of Polygala tenuifolia Willd. seedling roots

Following prometryne treatment,Polygala tenuifolia Willd. (Polygala) seedlings were investigated histochemically and biochemically to determine the effects of prometryne on root activity,lipid peroxidation,membrane integrity,reactive oxygen species(ROS) accumulation and antioxidant enzyme activity.There was no significant difference between untreated controls and seedlings treated with 10 mg/L prometryne in terms of root activity,membrane permeability and ROS production.Seedlings treated with 25—400 mg/L prometryne showed significantly accelerated ROS production,enhanced loss of membrane integrity and inhibited root cell viability.Histochemical staining with Schiff′s reagent,Evans blue,nitroblue tetrazolium and 3,3-diaminobenzidine was positively correlated with the accumulation of malondialdehyde(MDA),loss of membrane integrity,generation of superoxide radicals(O·-2) and generation of hydrogen peroxide(H2O2),respectively.Prometryne-induced oxidative stress triggered significant changes in the antioxidant defense machinery.At lower prometryne concentrations,the antioxidant defense system of Polygala seedlings demonstrated very efficient and coordinated enzymatic(superoxide dismutase;catalase;ascorbate peroxidase;peroxidase) and non-enzymatic(non-protein amino acids;proline) scavenging of ROS to regulate the cascades of uncontrolled oxidation and protect plant cells from oxidative damage.Higher prometryne levels increase oxidative stress through excessive production of ROS and destruction of antioxidant systems,ultimately leading to seriously damaged Polygala seedlings.The presented results indicate that Polygala seedlings are very sensitive to prometryne exposure during germination;however,the application of 10 mg/L is safe for seedling growth.Treatment at 25 mg/L prometryne can cause significant oxidative stress and lipid peroxidation as well as damage cell membrane integrity,leading to decreased root activity and inhibited seedling growth.These results may provide a theoretical basis for the mechanisms of herbicide resistance and the safe use of herbicides during Polygala cultivation.
Synthesis of age data and chronology for Florida Bay and Biscayne Bay cores collected for ecosystem history of South Florida’s estuaries project

Introduction . 1 Acknowledgements . 2 Methods . 2 Pb Analyses . 6 Pollen Biostratigraphic Analyses . 6 C Analyses . 16 Development of Age Models . 16 Synthesized Age Information . 16 Biscayne Bay, Rickenbacker Bank.16 Biscayne Bay, Featherbed Banks . 18 Biscayne Bay, No Name Bank . 18 Biscayne Bay, Black Point.23 Biscayne Bay, Card Bank.25 Biscayne Bay, Middle Key Basin.25 Biscayne Bay, Manatee Bay . 29 Florida Bay, Little Madeira Bay/Taylor Creek mouth . 29 Florida Bay, Russell Bank . 32 Florida Bay, Bob Allen mudbank . 32 Florida Bay, Whipray Basin . 32 Florida Bay, Rankin Basin . 36 Additional Age Data from Florida Bay Sites . 36 Summary of Results of Age Analyses for Biscayne Bay and Florida Bay . 38 Discussion and Future Directions . 38 References Cited . 40
Clinical outcome of whole body gamma knife therapy inoperable stage I/II non-small Cell lung Cancer

目的 评价全身γ刀治疗Ⅰ、Ⅱ期非小细胞肺癌的疗效和放射反应. 方法 对43例因医学原因不能手术的Ⅰ、Ⅱ期非小细胞肺癌采用国产全身γ刀治疗,用真空负压袋固定体位、慢速CT定位扫描和三维治疗计划. PTV边缘总剂量50%剂量线50 Gy分10次2周完成(肺门肿大淋巴结40 Gy),中心最大剂量80～100 Gy,70 Gy覆盖GTV 90%以上. 中位随访时间27个月. 结果 治疗后3～6个月,原发灶完全缓解率为63%,总有效率为95%. 1、2、3年肿瘤局部控制率均为95%,1、2、3年总生存率Ⅰ期分别为100%、91%、91%、Ⅱ期分别为73%、64%、64%、Ⅰ+Ⅱ期分别为88%、78%、78%. 肺早晚期反应较轻,3级放射性肺炎仅1例. 放射性食管反应在周围型肺癌中没有,中心型肺癌的9例中,1级8例,2级1例. 结论 我国独创的全身γ刀治疗早期非小细胞肺癌局部控制率和生存率较好,而且放射反应轻,是一种安全有效的局部治疗手段。
Neurophenotyping of Zebrafish Larvae that Are Preconditioned with Anesthetic Agent

Anesthetics evoke a stress-response, upregulating heat shock genes. This neuroprotective response to proteotoxic stress represents preconditioning, a process by which neuronal tissue, previously exposed to anesthetics, is protected against future insult. It presumes a sub-lethal injury, affecting protein unfolding. Our hypothesis is: preconditioning evokes molecular events that result in downstream changes that offer a selective advantage in terms of neuronal function. We focused on the neurobehavioral aspects which we neurophenotyped. Larval zebrafish were exposed to trifluoroethanol (TFE), an anesthetic mimetic, and tested for both individual and group behavioral markers of neuronal function. In bright/dark tests, we observed that TFE-exposed larvae spent more time in the dark area (typically an adult-like response) than control larvae. The response of TFE larvae to noise startle was directly opposite to that of controls. TFE larvae swam towards the source of the startle (into the bright zone), whereas control larvae swam away from the source of the startle (into the dark), typical of fear-response. The larvae also exhibited several differences in social behaviors, including synchronized schooling and shoaling behaviors. The TFE-group showed a greater number of synchronized events versus controls. The TFE-group also exhibited more shoaling events compared with controls. While the long-term effects have yet to be determined, these results shed light on the mechanism of anesthetic preconditioning. These complex zebrafish behaviors normally develop with age and therefore represent, in the TFE-exposed group, a pattern of accelerated maturation of neuronal function, which is the neurophenotype attributed to preconditioning.
Abordagem policial: um encontro (des)concertante entre a polícia e o público

Este artigo explora a relação entre a polícia e o público durante a abordagem policial, com o objetivo de oferecer maiortransparência a esse encontro, dando ênfase à conduta individual dos atores envolvidos.A análise apresentada nesteestudo é baseada em uma amostra de 90 abordagens, realizada no período de dois meses do ano de 2006, na cidadede São Paulo. Os dados foram coletados por meio da técnica da Observação Social Sistemática, que consiste em ummétodo de observação direta, porém não participante. Esta técnica permitiu observar o policial desempenhando suasatividades de policiamento sem que soubesse que estava sendo observado.
Generating criteria for assessing lecturers in Vietnam's universities: A conceptual paper

Despite the abundance of teacher assessment and evaluation models found in the literature, few have been designed for tertiary teachers – lecturers – at higher education institutions. Similarly, there have not been any competency based criteria and/or models to assess lecturers in Vietnam. Generating criteria for assessing university teachers nationally, therefore, is both a keystone of the country’s quality assurance endeavour and a challenge to educators involved in concurrent education reform. Such criteria, if deemed appropriate by the government, lecturers and other educational stakeholders should reflect the teachers’ duties and responsibilities stipulated in the country’s Education Law, the multiple roles they play in the changing society as well as the essential, context bound attributes of the profession. They should also reflect current knowledge and understanding of teaching and learning, especially student outcomes, as well as professionalism in higher education. Furthermore, these criteria should be the compromises between Confucianism and constructivism; between teacher creativity, innovation and teacher mundane duties as well as between genuineness and social desirability.
Ornithological data relevant to the spread of Avian Influenza in Europe phase 2

The risks associated with the spread of the Highly Pathogenic Avian Influenza (HPAI) virus strain of the H5N1 sub-type have featured prominently as an issue of international concern. HPAI H5N1 not only represents a serious threat to domestic poultry (economic aspect) but also a serious potential risk to humans (public health aspect). It is also an issue which could have serious consequences for the wild birds and other species of conservation concern (ecological aspects). Addressing the threats posed by HPAI H5N1 is a multi-disciplinary challenge which requires the inputs and close collaboration of different experts, including veterinarians, virologists, epidemiologists, ornithologists and conservation managers.
Avoiding the Alignment Trap in IT

For many years now, companies seeking to deliver higher business performance by harnessing IT have focused on alignment ? the degree to which the IT group understands the priorities of the business and expends its resources, pursues projects and provides information consistent with them. In practical terms, that means there must be shared ownership and shared governance of IT projects. However, the authors contend that their research ? a survey of more than 500 senior business and technology executives worldwide, followed up with in-depth interviews of 30 CIOs ? reveals a troubling pattern: Even at companies that were focused on alignment, business performance dependent on IT sometimes went sideways, or even declined. That? s because underperforming capabilities are often rooted not just in misalignment but in the complexity of systems, applications and other infrastructure. The complexity doesn? t magically disappear just because an IT organization learns to focus on aligned projects rather than less aligned ones. On the contrary, the authors say, in some situations it can actually get worse. Costs rise, delays mount and the fragmentation makes it difficult for managers to coordinate across business units. The survey also showed that almost three-quarters of respondents are mired in the ? maintenance zone. IT at these companies is generally underperforming, undervalued and kept largely separate from a company? s core business functions. Corporate management budgets the amounts necessary to keep the systems running, but IT doesn? t offer enough added value to the business and often isn? t expected to. Drawing on the experiences of Charles Schwab & Co., Selective Insurance Group, De Beers, First Data Corp. and National City, among others, the authors identify a group of best practices that constitute ? IT-enabled growth. The companies that achieve the highest growth at a low cost manage complexity down, source IT staffing and software wherever it makes the most sense and create start-to-finish accountability connected to business results. Then, and only then, the best performers tightly align their entire IT organization to the strategic objectives of the overall business, using governance principles that cross organizational lines and making business executives responsible for key IT initiatives.
ulmonary Blood Flow Patterns in Patients With ontan Circulation

fl c t Background. After Fontan surgery there is no subpulonary ventricle to modify pulmonary blood flow. The nfluence of the cardiac cycle on pulmonary blood flow atterns in various types of Fontan patients is unknown. Methods. Blood flow patterns were investigated using hase-velocity cine magnetic resonance imaging in the ulmonary artery of 17 patients (21.1 7.3 years old, 6 emales) with Fontan circulation. These patterns were ompared with those of 12 healthy volunteers (26.3 6.0 ears old, 10 females) obtained in the superior vena cava nd the main pulmonary artery. Measurements were ampled for a period of about 3 minutes to rule out espiratory effects. Blood flow patterns were depicted by nterpolating the variable number of measured phases in very patient to 100 phases and normalizing flow to mean lood flow in that vessel. Then, average flow patterns
Magnetic resonance imaging approaches to gel dosimetry for validation of conformal radiotherapy treatment plans

Gel dosimeters are suitable for the purpose of 3-D dose verification using imaging methods such as magnetic resonance (MR) imaging, which can provide a spatial resolution of ~1 mm or better. The two main kinds of gels investigated to date (Fricke and polymer-based gel dosimeters) face various problems which have impeded their full clinical use. The Fricke-based gel dosimeters suffer the problem of spatial information loss with time due to diffusion of radiation-induced ferric ions. Polymer-based gels are quite toxic (carcinogens, teratogens etc) and can’t be prepared in normoxic conditions. Possible solutions to these problems are the use of fast imaging methods to limit diffusion for Fricke gels and development of less or non toxic gels for the case of polymer gels. In this thesis, the ability of the MR imaging Look-Locker method to act as a dose verification tool for Fricke gel dosimeters due to its speed is studied. This is done through the modification of the conventional Look-Locker method to accommodate larger tip angles thereby improving on its precision and accuracy. The optimum method of acquiring the image data in Fourier or k-space so as to limit the effect of image blurring due to a time point spread function inherent of this imaging method is proposed. Also studied is the prospect of using two new polymer-based gel dosimeters with reduced toxicity as a dose verification tool. This is demonstrated by verifying a treatment planned dose distribution using these gel dosimeters and MR imaging. A multiple spinecho MR imaging sequence is used as the imaging tool, with possible problems which can affect the accuracy of the measured dose distribution such as Bi field inhomogeneity and geometrical distortions due to non-linear gradient magnetic fields mapped out and corrected for.
Antibiotic Susceptibility of Conjunctival Microflora of Cataract Patients Prior to Surgery in Wukari LGA, Taraba State, Nigeria

The eye harbours bacteria that make up its indigenous flora. These bacteria are capable of causing diseases when they lose co-dependence and co-regulation with the host. The ocular bacterial flora of one hundred cataract patients submitted for surgery were studied. At least 72 hours prior to sample collection, patients were placed on topical application of amethocaine. Conjunctival swabs were collected from each of the cataractous eyes and cultured aerobically on Blood, MacConkey, and Nutrient agar. Bacterial isolates were then subjected to antibiotic sensitivity testing to discern antibiotic susceptibility and resistance patterns. Of the 100 patients submitted for surgery, 60% were males while 40% were females while their ages ranged from 4 – 90. Of the 134 eyes sampled, only 62 (46.3%) were culture sensitive. Of the 111 bacterial isolates recovered from the 62 culture sensitive samples, 83 (74.8%) were coagulase negatives Staphylococcus, 17 (15.3%) were Staphylococcus aureus, 7 (6.3%) were Corynebacteriumspp while 4 (3.6%) were Streptococcus spp. The bacterial isolates recovered showed little resistance to Ampiclox (6.2%) and Amoxil (8.7%), some showed intermediate susceptibility to Chloramphenicol (3.1%), while 100% susceptibility were discovered for the other tested antibiotics. The importance of these organisms, especially those showing resistance and intermediate susceptibility to antibiotics, in the pathogenesis of post-cataract surgery complications is worrisome. Hence, good knowledge of ocular bacterial flora of healthy individuals and patients is important in maintaining good eyesight as well as choosing antibiotic for prophylaxis of post-cataract complications.
Nobel to immunotherapy in cancer

1Gene Therapy Program, Fundación para la Investigación Médica Aplicada, CIMA, Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Av. Pio XII 55, Pamplona 31008, Spain 2Oncohematology Research Group, Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA). Irunlarrea 3. 31008 Pamplona, Spain
Integrating research teams: the TELMA approach

In the context of the Kaleidoscope Network of Excellence, six European research teams developed a methodology for integrating their research approaches. In this paper we present the methodology, based on a cross experiment, showing how it gave insight to the understanding of each team's research, and on the relationship between theoretical frameworks and experimental research.