Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on connected vehicle architecture based on DSRC technology

Intelligent Transportation System (ITS) is recognized as one of the most effective means to solve the problem of modern traffic, and connected vehicle technology is a key link in the intelligent transportation system, which plays a Decisive role in the impact of intelligent transportation. This paper introduces the architecture of connected vehicle which based on DSRC technology, the operating mechanism, and its application. Finally, the connected vehicle platform we have been building is introduced, and it needs further research.
Detection of p53 autoantibodies in sera of gastric cancer patients and their prognostic relevance.

BACKGROUND Changes in the p53 gene product can be immunogenic and enable the formation of p53 serum antibodies (p53ab), detectable in patients with different cancer types. So far, there have been no reports describing the detectability of p53ab in gastric cancer patients. METHODS We investigated the presence of p53ab and their clinical relevance in a cohort of 74 gastric cancer patients, using an enzyme-linked immunosorbent assay system. RESULTS In our investigation 20.3% of all patients (15 of 74) and 46.9% of the patients with immunohistochemically (IHC) p53-positive tumors (15 of 32) showed detectable p53ab in serum. All p53ab-positive patients had IHC p53-positive tumors. We have found a significant correlation of p53ab with a higher tumor stage (P = 0.002) and also with a poor prognosis of survival (P = 0.04). CONCLUSION We have shown that in gastric cancer patients p53ab are also detectable and that p53ab positivity is a predictor of an unfavorable prognosis.
PROGRESS WITH THE GENETICS OF INSULIN‐DEPENDENT DIABETES MELLITUS

For over 2000 years it has been appreciated that there are two types of diabetes, and that both genetic and environmental factors are involved in the manifestation of these diseases (Frank, 1957). Diabetes has been described by Nee1 (1952) as a geneticist’s nightmaremany reasons account for this statement. Firstly, precise definitions of insulin-dependent diabetes (IDDM) and non-insulin dependent diabetes mellitus (NIDDM) do not exist; there are only broad guidelines (i.e. National Diabetes Data Group, 1979). Whilst it is easy to recognize typical examples of both diseases-the obese middle-aged insulinresistant NIDDM and the thin young insulin-dependent diabetic who has had an episode of ketoacidosis-many patients evade precise classification. Perhaps diabetes should be considered as a heterogeneous disorder which is a continuous spectrum between the two classic syndromes of NIDDM and IDDM. The many rare genetic syndromes associated with diabetes provide additional heterogeneity within this disease (Rotter & Rimoin, 1981). Another major problem in most population studies is that the diseased and control populations are rarely well matched for both race and clinical characteristics; for instance the frequent statement that ‘only Caucasoid subjects were studied’ may obscure a considerable range of unappreciated ethnic heterogeneity. Lastly, as diabetes is likely to be a polygenic disease, studying a single gene locus in isolation is likely to give only a very incomplete picture of the genetic background. Despite these many problems significant advances in the understanding of inherited factors in IDDM has occurred in the last 20 years. The aim of this article is to review the genetics of IDDM with emphasis on recent studies at the DNA level.
Transradial prostheses: Current status and future directions

Transradial prosthesis is an artificial wearable limb that provides the functionality and/or appearance of human wrist and hand. Over the recent years, both hardware and control systems for active transradial prosthesis show significant advancement. In that context, this paper reviews the modern transradial prostheses developed for performing activities of daily living. Focus is to provide an insight on the latest technologies, including mechanical designs and control algorithms developed to mimic the biological wrist and hand. The biomechanics of below-elbow of upper-limb and functional requirements such as grasping motion are initially presented. The design difficulties are discussed in the following section. Next, each of the modern transradial prosthesis are briefly reviewed based on design and/or control of fingers, wrists and body attachments. Finally, latest trends and future directions for developing transradial prostheses are explored and unveiled.
Self-Organized Pedestrian Crowd Dynamics: Experiments, Simulations, and Design Solutions

To test simulation models of pedestrian flows, we have performed experiments for corridors, bottleneck areas, and intersections. Our evaluations of video recordings show that the geometric boundary conditions are not only relevant for the capacity of the elements of pedestrian facilities, they also influence the time gap distribution of pedestrians, indicating the existence of self-organization phenomena. After calibration of suitable models, these findings can be used to improve design elements of pedestrian facilities and egress routes. It turns out that "obstacles" can stabilize flow patterns and make them more fluid. Moreover, intersecting flows can be optimized, utilizing the phenomenon of "stripe formation. " We also suggest increasing diameters of egress routes in stadia, theaters, and lecture halls to avoid long waiting times for people in the back, and shock waves due to impatience in cases of emergency evacuation. Moreover, zigzag-shaped geometries and columns can reduce the pressure in panicking crowds. The proposed design solutions are expected to increase the efficiency and safety of train stations, airport terminals, stadia, theaters, public buildings, and mass events in the future. As application examples we mention the evacuation of passenger ships and the simulation of pilgrim streams on the Jamarat bridge. Adaptive escape guidance systems, optimal way systems, and simulations of urban pedestrian flows are addressed as well.
Onherhaalbaar, onontdoenbaar: Die doop as simbool van eenheid in die kerk

Irrevocably singular: Baptism as a symbol of unity in the church. In this article I conduct a phenomenological analysis of the concept ‘one baptism’ in Ephesians 4:4−6. Such an analysis seeks to reveal the essence of a particular concept by bracketing out the theological and ideological presuppositions usually associated with it. The essential concept is then expanded by linking it to the terms most closely surrounding it in the text. A critical theological reflection on the expanded concept shows that ‘one baptism’ refers to an event by which believers are inducted, once and for all, into the church as the one body of the one Lord, Jesus Christ. The church exists through the presence of the one Spirit who binds believers in an unbreakable bond of love to God and to each other. Because baptism can never be undone or repeated, any liturgical act depicted as a ‘re-baptism’ is, by definition, impossible. This means that churches that baptise the children of believing parents are able to accommodate requests from people who, having been baptised as an infant, in later life wish to celebrate and testify to some significant milestone in their spiritual journey by means of an official church ritual. Such ritualised testimonies, however, refer to the existential lifeworld of believers (their repentance, confession of faith etc.) and are distinct from baptism that refers to the singular eschatological work of Christ and thus cannot be repeated. The church should, however, take pastoral care to ensure that people do not substitute their own spiritual experiences for the reality of salvation that is founded on the singular act of God, for us once and for all in Christ, to which baptism irrevocably refers.
A fully integrated power-management solution for a 65nm CMOS cellular handset chip

For cellular handset ICs, integrating the power management unit (PMU) in the same chip as the baseband and the radio is critical for footprint and cost reduction, however, it presents unique challenges in terms of device reliability, bill of materials (BOM) and PMU performance. In this paper, a PMU integrated as part of a GSM/EDGE chip in a 65nm deep-Nwell CMOS process (Fig. 22.1.1), comprising a battery charger, a regulated inverting charge pump, multiple regulators. and a White LED (WLED) driver is presented. The battery charger supports various charging profiles up to VCHG=12V and can tolerate up to 20V. A regulated charge pump (CP) operating directly from the battery (VBAT) provides negative supply for earphone class-AB audio power amplifiers (APA) for ground referred headset connectors. A buck converter and several linear regulators supply the various sub-systems on the chip as well as external modules (SIM Card/Camera/Interfaces etc.). An inductive-boost WLED driver drives up to 6 LEDs in series or up to 3 in parallel.
Treatment of paediatric headache

Headaches are very common during childhood and become increasingly frequent during adolescence. The diagnosis of primary headache disorders (e.g., migraine and tension-type headache) rests principally on clinical criteria as set forth by the International Headache Society. Treatment options include acute or episodic measures, prophylactic agents and non-pharmacological or behavioural interventions. From review of available evidence, the most efficacious acute treatments of paediatric migraine include the non-steroidal anti-inflammatory agent ibuprofen at 7.5 – 10 mg/kg/dose or nasal sumatriptan at doses of 5 or 20 mg. For those patients with headaches that occur with sufficient frequency and severity to warrant daily prophylaxis, controlled data are limited. Agents which are likely to be beneficial include amitriptyline, flunarizine (not available in the US) and cyproheptadine. Clinical experience with the anti-epileptic agents topiramate and valproate suggests an expanding role for the prevention of paediatric migraine in the future.
Data-Driven Analysis Strategies for Proportion Studies in Adaptive Group Sequential Test Designs

Abstract Using multistage adaptive group sequential test designs, the investigator may perform data-driven changes in the design during the course of the trial without inflation of the Type I error rate. This is possible, for example, through the use of the inverse normal method of combining the p-values from the separate stages of the trial. Generally, conditional error functions are useful instruments for midtrial design modifications of clinical trials. Particularly, it is worthwhile to consider sample size reassessment strategies based on conditional power arguments. In this paper, approximate techniques will be proposed for the application of the inverse normal combination testing principle in superiority and noninferiority proportion studies. Planning facilities and the adaptive analysis strategies will be discussed in terms of the Type I error rate, the necessary sample size, and the power within the adaptive design. Furthermore, how to calculate confidence intervals and overall p-values will be shown.
Effects of Acupuncture on Gait of Patients with Multiple Sclerosis.

BACKGROUND Multiple sclerosis is considered a complex and heterogeneous disease. Approximately 85% of patients with multiple sclerosis indicate impaired gait as one of the major limitations in their daily life. Acupuncture studies found a reduction of spasticity and improvement of fatigue and imbalance in patients with multiple sclerosis, but there is a lack of studies regarding gait. DESIGN We designed a study of acupuncture treatment, according to the Heidelberg model of Traditional Chinese Medicine (TCM), to investigate if acupuncture can be a useful therapeutic strategy in patients with gait impairment in multiple sclerosis of relapsing-remitting type. The sample consisted of 20 individuals with diagnosis of multiple sclerosis of relapsing-remitting type. Gait impairment was evaluated by the 25-foot walk test. RESULTS The results showed differences in time to walk 25 feet following true acupuncture. In contrast, there was no difference in time to walk 25 feet following sham acupuncture. When using true acupuncture, 95% of cases showed an improvement in 25-foot walk test, compared with 45% when sham acupuncture was done. CONCLUSIONS Our study protocol provides evidence that acupuncture treatment can be an attractive option for patients with multiple sclerosis, with gait impairment.
Prospectively randomized clinical trial to compare in situ and reversed saphenous vein grafts for femoropopliteal bypass

Two hundred and fifteen femoropopliteal bypass procedures using autologous saphenous vein grafts were randomly allocated to either the reversed or in situ technique. Eleven veins (5 per cent) were rejected at operation on the basis of their small size, nine in the reversed group and two in the in situ group, and there were two (2 per cent) perioperative deaths in each group, leaving 102 reversed and 98 in situ grafts for further study. The cumulative patency at 3 years of the reversed grafts was 77 per cent and that of the in situ grafts was 68 per cent (n.s.). The patency of all grafts was affected adversely by small veins (P <0·005), long grafts (P <0·05), low volume of blood flow in the grafts (P <0·001) and poor run‐off (P <0·05). These factors influenced the outcome of the in situ and reversed operations to a similar degree and there was no statistically significant difference between them within any subgroup. The mean compliance of the in situ grafts measured 3 months or more after operation with an ultrasonic echo‐tracking system was 0·024 ± 0·01 per cent/mmHg (± s.d.) compared with 0·017 ± 0·01 per cent/mmHg for the reversed grafts (t = 2·43, P <0·02). The incidence of fibrous stricture formation as shown by intravenous digital subtraction angiography was 29 per cent in both the reversed and the in situ grafts. The results of the study to date indicate that reversed and in situ vein grafts are equally effective for femoropopliteal bypass.
Epidemiological profile of patients suspected with meningitis : A cross-sectional study among 1712 Egyptian patients

Patients suspected with meningitis can fall into three main categories including meningitis, encephalitis or meningism. Each category has its own epidemiological features; however clinical presentations can be non-discriminating in many instances. Studying the epidemiological features of such cases can help in defining more clues for discriminating these categories. The aim of this study is to describe the epidemiology of acute meningitis, encephalitis and meningism in 1712 cases presented to Shebin ELKom Fever Hospital with suspected meningitis. A total of 1712 Egyptian patients suspected with acute meningitis admitted to Shebin El-Kom Fever Hospital were studied according to demographic features and disease outcome. Meningitis was diagnosed in 36.4% of cases, encephalitis in 17.3%, while the largest percentage of 46.3% was diagnosed as meningism. Meningitis was higher in pre and post school age groups. Encephalitis peak above 60 years and meningism was below 6 years. Each group showed significant male and rural area predominance (p >0.001). Encephalitis showed higher mortality as compared to meningitis and meningism. Age grouping can be useful to discriminate cases suspected with meningitis. CNS affection is a common disease in male gender, rural communities and summer season. Meningitis and encephalitis are serious diseases with lethal outcome.
Fibrous Connective Tissue Lesion Mimicking a Vestibular Schwannoma: Case Report

OBJECTIVE AND IMPORTANCECerebellopontine angle fibromas are rare pathological entities that can mimic the presentation of vestibular schwannomas (VSs). Diagnosis of these benign lesions, however, is important, because treatment options may be different. The clinical, radiological, and intraoperative features of these unusual lesions of the cerebellopontine angle are discussed, with review of the relevant literature. CLINICAL PRESENTATIONA 41-year-old man presented with recurrent episodes of diminished hearing on the left side, accompanied by facial ticks and pain on the same side. Magnetic resonance imaging and computed tomographic scans revealed a 1.5-cm, primarily intracanalicular lesion, suggesting a left VS. INTERVENTIONThe lesion was partially removed through a retrosigmoid suboccipital craniotomy. Its intraoperative appearance and hard fibrotic consistency differed from the classic features of VSs. The pathological findings indicated nontumoral fibrous connective tissue. The lesion exhibited no features of inflammation or fat and was also negative for S-100 staining. Follow-up magnetic resonance imaging scans demonstrated a small residual lesion, which exhibited shrinkage in subsequent magnetic resonance imaging studies. The painful ticks disappeared and facial nerve weakness improved postoperatively. CONCLUSIONAlthough cerebellopontine angle fibromas may present similar radiological features, their clinical presentation may be somewhat different from that of typical VSs. If a fibroma is suspected, radiosurgery should be avoided; limited surgery may be considered as an option for patients experiencing symptoms. Because fibromas may be intraoperatively noted to be fibrotic and vascular, radical removal may not be easy or justified. After the final diagnosis has been reached, conservative treatment of the residual lesion may be the best option.
Pragmatic Substantiation Of An Efficient Test Data Generation Algorithm Based On Adequacy Testing Criteria

The length and the complexity of the software are rising day by day. This rising complexity has increased the demand for techniques that can generate test data effectively.Test data generation techniques selects from the input domain of the program, those input values that satisfies a pre-defined testing criteria. In this paper, we propose a new test data generation algorithm. Our algorithm generates test data using adequacy based testing criteria that aims to generate an adequate test data set by using the concept of mutation analysis. In general, mutation analysis is applied after the test data is generated. But, our algorithm applies mutation analysis at the time of generating test data only rather than applying it after the generation of test
Goat ovarian follicles express different levels of mRNA for inhibin-ßA subunit and activin-A stimulates secondary follicle growth in vitro

This study investigated the levels of messenger ribonucleic acids (mRNA) for inhibin-sA subunit in goat primordial, primary and secondary follicles, as well as in cumulus-oocyte complexes (COCs) and mural granulosa / theca cells of antral follicles. The effects of activin-A (100ng mL-1) and/or follicle stimulating hormone (FSH, 50ng mL-1) on growth and expression of mRNA for activin-A and FSH receptor (FSH-R) in secondary follicles cultured for six days were evaluated. The data showed that the expression of inhibin-sA is lower in secondary follicles than in primary follicles and is higher in large antral follicles than in small antral follicles. After culture, activin-A and/or FSH promoted growth of secondary follicles, while FSH increased the levels of mRNA for inhibin-sA, and activin-A increased the levels of FSH-R mRNA. In conclusion, mRNA for inhibin-sA is expressed at different levels in pre-antral and antral follicles and activin-A acts as a stimulator of the FSH-R expression in goat follicles. On its turn, the expression of inhibin-sA is stimulated by FSH, which together with activin-A promotes secondary follicle growth in-vitro.
Antiparallel and Interlinked Control of Cellular Iron Levels by the Irr and RirA Regulators of Agrobacterium tumefaciens

ABSTRACT The plant pathogen Agrobacterium tumefaciens encodes predicted iron-responsive regulators, Irr and RirA, that function in several other bacteria to control the response to environmental iron levels. Deletion mutations of irr and rirA, alone and in combination, were evaluated for their impact on cellular iron response. Growth was severely diminished in the Δirr mutant under iron-limiting conditions, but reversed to wild-type levels in an Δirr ΔrirA mutant. The level of uncomplexed iron in the Δirr mutant was decreased, whereas the ΔrirA mutant exhibited elevated iron levels. Sensitivity of the Δirr and ΔrirA mutants to iron-activated antimicrobial compounds generally reflected their uncomplexed-iron levels. Expression of genes that encode iron uptake systems was decreased in the Δirr mutant, whereas that of iron utilization genes was increased. Irr function required a trihistidine repeat likely to mediate interactions with heme. Iron uptake genes were derepressed in the ΔrirA mutant. In the Δirr ΔrirA mutant, iron uptake and utilization genes were derepressed, roughly combining the phenotypes of the single mutants. Siderophore production was elevated in the rirA mutant, but most strongly regulated by an RirA-controlled sigma factor. Expression of rirA itself was regulated by Irr, RirA, and iron availability, in contrast to irr expression, which was relatively stable in the different mutants. These studies suggest that in A. tumefaciens, the Irr protein is most active under low-iron conditions, inhibiting iron utilization and activating iron acquisition, while the RirA protein is active under high-iron conditions, repressing iron uptake.
Performance of materials in vascular prosthetic devices: heart valves.

D URING the first few years that prosthetic replacement of a heart valve was carried out, the flexible variety of artificial valve leaflets made of Teflon fabric were used almost exclusively. Although the design and hemodynamic function of these valves was satisfactory, the material from which the leaflets were constructed was not durable enough and, in time, they demonstrated excessive wear as manifested by tears in the leaflet substance, especially at the flexion creases. Surgeons then turned their attention toward the rigid artificial prosthetic valve, and this is the type most frequently used clinically for the replacement of a valve at the present time. The rigid prosthetic valve presently employed for replacement of a valve is usually of the ball-valve or low-profile design. It is made of materials demonstrated to be biologically compatible in the bloodstream. The sewing ring is usually of a fabric: Teflon, Dacron, or polypropylene; the cage is of metal: Stellite 2i, a chromium-molybdenum alloy, or of titanium, a pure noncorrosive material, being most commonly used. A number of substances have been used for the moving poppet, including Stellite 2I, Teflon, and polypropylene. Two different prosthetic models are commonly available from each valve manufacturer in a range of sizes-one for the aortic valve and another for the mitral or tricuspid position. Most of the rigid valves have fabric fixation sewing rings and require the placement of multiple sutures to hold them in place. This is a time-consuming and tedious process. In order to avoid this, one type
Effective Transmission Coverage Area-Based Link Dynamics Characterization of VANET in Highway Scenario

This paper uses the concept of effective transmission coverage area as a model for the derivation of analytic expressions in order to characterize the dynamic statistics of link lifetime, new link arrival rate, new link interarrival time, link breakage interarrival time, and so forth. Extensive simulations have been undertaken to verify the derived analytical expressions via generated mobility traces. Results demonstrate that the proposed analytical model can characterize the dynamic statistics well. Furthermore, the mathematical results of expected link life and expected new link arrival rate are provided to be used in analyzing the network connectivity. Combining with queueing theory, the upper bound connectivity of a VANET is obtained. This work thus provides a fundamental guideline on designing new mobility models, new routing protocols, and the corresponding performance analysis in VANET.