Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility of simultaneous measurement of bone formation and bone resorption markers to assess bone turnover rate in postmenopausal women: an EPOLOS study.

BACKGROUND One of the most important risk factors for osteoporotic fractures in postmenopausal women is elevated bone turnover (EBT), occurring in 25-30% of this population. This study's aim was to find a correlation between bone resorption and bone formation markers to assess bone turnover rate and qualify an individual postmenopausal woman as a possible EBT subject. MATERIAL/METHODS Three hundred twenty postmenopausal women (> or = one year after the last menstruation, < or = 70 years old) were enrolled at seven clinical sites in this cross-sectional observational study conducted within the EPOLOS. The group was a random sample of the population. The study was performed in a referral center involved in the diagnosis and treatment of osteoporosis. The exclusion criteria included pregnancy, cancer, fracture in the last year, and overweight (> 100 kg). Bone mineral density (BMD) measurements of the lumbar spine, total hip, trochanter, and femoral neck regions were performed. Bone resorption and formation rates were evaluated by serum levels of C-terminal telopeptide of type I collagen (CTX) and osteocalcin (OC), respectively. RESULTS Using logistic regression to correlate the concentrations of CTX and OC it was possible not only to distinguish the EBT subgroup, but also to construct a simple nomogram for easy classification of individual patients as possible EBT subjects. EBT patients showed generally decreased BMD values and increased bone formation and resorption rates. CONCLUSIONS Evaluation of both CTX and OC levels enables a more proper indication for EBT. The proposed nomogram may assist in evaluating outcome from the two markers of bone turnover.
Stadium Games in Entrepreneurial Cities in China: A State Project

Abstract Cities in China have started to build sport-related infrastructure in earnest; over 1.6 million sport facilities (including 1,093 large-scale sport stadiums and arenas) were built in China from 2003 to 2013. However, operating losses have created concerns of a debt crisis, sparking debate as to whether stadium and arena development can improve the quality of life of residents. This paper examines China’s arena development strategy over the past decade, and finds that development has been undertaken by local governments for two purposes: (1) local development and growth to increase urban competitiveness; and (2) establishing “human-centered” infrastructure to symbolically position the city to gain the state’s sustained support in competition for resources with other cities. Thus, cities do not invest public funds principally in the name of increased tourism, commercial development, or even civic pride but rather as a means for the city to be elevated in the eyes of the central government.
Progesterone Receptor Isoform Analysis by Quantitative Real-Time Polymerase Chain Reaction in Formalin-Fixed, Paraffin-Embedded Canine Mammary Dysplasias and Tumors

Cloning and sequencing of the progesterone receptor gene in dogs have revealed 2 isoforms, A and B, transcribed from a single gene. Distribution of isoforms A and B in canine mammary lesions has hitherto been investigated only by Western blot analysis. This study analyzed progesterone receptor and its isoforms in formalin-fixed, paraffin-embedded tissue samples from canine mammary lesions (4 dysplasias, 10 benign tumors, and 46 carcinomas) using 1-step SYBR Green quantitative real-time polymerase chain reaction (RT-qPCR). Progesterone receptor was expressed in 75% of dysplasias, all benign tumors, and 59% of carcinomas. Carcinomas, and particularly simple epithelial-type carcinomas, displayed the lowest levels of expression. A high rate of agreement was recorded between RT-qPCR and immunohistochemical labeling. Isoforms A and B were successfully amplified, with correlation coefficients of 0.99 and amplification efficiencies close to 2, and were expressed in all lesion types analyzed. Predominance of A over B expression was observed in carcinomas and complex adenomas. Low-grade tumors exhibited higher progesterone receptor messenger RNA (mRNA) levels, but no difference was observed in the expression of isoform A versus B. Analysis of progesterone receptor mRNA isoforms by RT-qPCR was successful in routinely formalin-fixed, paraffin-embedded tissue samples and enabled the distribution of isoforms A and B to be identified for the first time in dysplasias, benign tumors, and malignant tumors of the canine mammary gland. These findings will facilitate future research into the role of progesterone receptor isoforms in the progression of canine mammary tumors.
Human natriuretic factor in cirrhotic patients undergoing orthotopic liver transplantation

We measured the plasma levels of atrial natriuretic factor (ANF) during orthotopic liver transplantation (OLT) in eight adult patients with cirrhosis and ascites. The aim of this study was to determine whether significant differences in ANF concentration may be detected during the individual phases of OLT and to correlate these changes with hemodynamics. In each patient a hemodynamic assessment was achieved using a Swan-Ganz fiber optic catheter for continuous monitoring of cardiac output (CO), systemic vascular resistance index (SVRI), right filling pressure as assessed by central venous pressure (CVP), and left filling pressure by means of pulmonary arterial wedge pressure (PAWP). During reperfusion a clear-cut increase in ANF values was observed (P<0.05). Concurrently, an increase in CVP (P<0.05) and a decrease in SVRI were observed without any significant increase in diuresis. These data suggest that ANF might play a role in the development of the reperfusion syndrome.
International Capital Flows at the Security Level: Evidence from the ECB's Asset Purchase Programme

The paper analyses euro area investors’ portfolio rebalancing during the ECB’s Asset Purchase Programme (APP) at the security level. Based on net transactions of domestic and foreign securities, the authors observe euro area sectors’ capital flows into individual securities, cleaned from valuation effects. Their empirical analysis – which accounts for security-level characteristics – shows that euro area investors (in particular investment funds and households) actively rebalanced away from securities targeted under the Public Sector Purchase Programme (PSPP) and other euro-denominated debt securities, towards foreign debt instruments, including ‘closest substitutes’, i.e. certain sovereign debt securities issued by non-euro area advanced countries. This rebalancing was particularly strong during the first six quarters of the programme. The analysis also reveals marked differences across sectors as well as country groups within the euro area, suggesting that quantitative easing has induced heterogeneous portfolio shifts.
Systematic literature review on corruption prevention efforts towards sustainable economy in Indonesia: ICT perspective

Corruption is an extraordinary crime and must be eradicated not only as fast as possible, but also as efficient and as effective as possible as it hinders the process of achieving sustainable economy. In current modern society, information technology exists as a multidisciplinary tool to solve lingering problems that could not be solved by traditional efforts. This paper aims to provide knowledge regarding identified efforts to fight corruption specifically in Indonesia region. Systematic Literature Review (SLR) methodology is used as the methodology, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow is used as framework to identify relevant records. Scopus database is used as data source. A total of 10 records are labelled as relevant to this research, and the findings are synthesized. It was found from the records that the main areas of interest for ICT research for corruption prevention in Indonesia are (1) information transparency, (2) operational enhancement, (3) success evaluation, (4) security and fraud, and (4) decision support. The findings are expected to assist future research in term of providing valuable insights on corruption prevention using ICT in Indonesia.
Clinical characteristics of triple-negative breast cancer: experience in an Asian developing country.

INTRODUCTION Triple negative (TN) breast cancers are defined by a lack of expression of oestrogen, progesterone, and HER2 receptors. They tend to have a higher grade, with a poorer outcome compared to non-TN breast cancers. OBJECTIVE The aim of this study is to determine the incidence of TN breast cancer in an Asian country consisting of Malays, Chinese and Indians, and to determine the factors associated with this type of breast cancer. RESULTS The incidence of TN breast cancer in the University Malaya Medical Center is 17.6%. There is no significant difference amongst the Malays, Chinese and Indians. In bivariate analysis, TN breast cancer was significantly associated with younger age and Grade 3. However, in multivariate analysis using logistic regression, TN breast cancer was only associated with Grade 3. CONCLUSION The incidence of TN breast cancer in our study is similar to other studies, and associated with a higher grade.
The contribution of enterprise establishment factors to employment growth of the pineapple industry in the Nsawam- Adoagyiri District in the Eastern Region of Ghana

The establishment of enterprises is influenced by various factors identified in the theories of enterprise establishment. However, most entrepreneurs do not pay particular attention to such factors when establishing and managing their enterprises. The aim of this study is to examine how enterprise establishment factors contribute to employment growth of the pineapple industry in Nsawam-Adoagyiri District. The enterprise establishment factors investigated in this study are the basic tasks identified by the entrepreneur, availability of funds for enterprise establishment, business information and entrepreneur’s expertise from previous education and previous work. A survey was conducted using mixed methods research. Data were collected from 172 entrepreneurs in the pineapple industry from eight farmer based organizations randomly selected from Nsawam-Adoagyiri District of Ghana. The data were analyzed with SPSS software using Chi square and multiple regression analysis. The results show that availability of funds for enterprise establishment contributed significantly to employment growth. The study found that business information did not contribute to employment growth of the pineapple industry in the study area. While entrepreneurs’ expertise acquired from educational background did not contribute significantly to employment growth of the industry, entrepreneurs’ expertise from previous work background contributed significantly to employment growth. The regression analysis showed that the enterprise establishment factors investigated in this research explain 52% of the variations in employment growth in the pineapple industry in the study area. It can therefore be concluded that enterprise establishment factors do not only influence the enterprise establishment process but also contribute to employment growth of the pineapple industry in the study area.
Automated Learning of Temporal Expressions

Clinical notes contain important temporal information that are critical for making clinical diagnosis and treatment as well as for retrospective analyses. Manually created regular expressions are commonly used for the extraction of temporal information; however, this can be a time consuming and brittle approach. We describe a novel algorithm for automatic learning of regular expressions in recognizing temporal expressions. Five classes of temporal expressions are identified. Keywords specific to those classes are used to retrieve snippets of text representing the same keywords in context. Those snippets are used for Regular Expression Discovery Extraction (REDEx). These learned regular expressions are then evaluated using 10-fold cross validation. Precision and recall are very high, above 0.95 for most classes.
Employee attitudes towards corporate social responsibility: a study on gender, age and educational level differences

Previous studies show that individual characteristics can influence stakeholder attitudes towards corporate social responsibility (CSR). This study analyses employee attitudes such as CSR demandingness, trust and satisfaction, to determine whether they vary according to differences in gender, age, and educational level. The analysis was carried out by surveying 153 employees of 11 Italian banks, and by performing a content analysis of the banks’ sustainability reports. The Italian banking sector was chosen because of recent financial and CSR scandals. The findings suggest that, on average, male employees are slightly more trustful in and satisfied with CSR performance than their female counterparts. Graduates are slightly more demanding, largely more trustful and generally more satisfied than non-graduates. Interestingly, the difference between older and younger employees is not significant. The proposed approach can be useful in designing tailored CSR activities and communication avenues by shedding light on employees’ CSR attitudes.
Entrepreneurship and Equity Crowdfunding: A Research Agenda

The potential of ‘the crowd’ to enhance investments, especially at levels previously that could reduce the financial constrain faced by new ventures, has led to the introductions of regulations to dominate crowdfunding activities. One of regulated areas is equity crowdfunding, which has the potential to disrupt the existing market provision for equity finance to early stage firms. This paper aims to provide a theoretical review of the extant literature. The results identify, from the perspective of entrepreneurs, equity investors and government, the key issues that potentially differentiate crowdfunding from other sources of equity finance and how these issues change the relationship between entrepreneurs and potential funders. Based upon the findings of the theoretical review, the paper suggests research directions in which future researchers can employ behaviour theory, agency theory and signalling theory to explore, investigate and further develop our understanding about equity crowdfunding within the entrepreneurial context.
Development of novel flurbiprofen-loaded solid self-microemulsifying drug delivery system using gelatin as solid carrier

To develop a novel flurbiprofen-loaded solid self-microemulsifying drug delivery system (solid SMEDDS) with improved oral bioavailability using gelatin as a solid carrier, the solid SMEDDS formulation was prepared by spray-drying the solutions containing liquid SMEDDS and gelatin. The liquid SMEDDS, composed of Labrafil M 1944 CS/Labrasol/Transcutol HP (12.5/80/7.5%) with 2% w/v flurbiprofen, gave a z-average diameter of about 100 nm. The flurbiprofen-loaded solid SMEDDS formulation gave a larger emulsion droplet size compared to liquid SMEDDS. Unlike conventional solid SMEDDS, it produced a kind of microcapsule in which liquid SMEDDS was not absorbed onto the surfaces of carrier but formed together with carrier in it. However, the drug was in an amorphous state in it like conventional solid SMEDDS. It greatly improved the oral bioavailability of flurbiprofen in rats. Thus, gelatin could be used as a carrier in the development of solid SMEDDS with improved oral bioavailability of poorly water-soluble drug.
Working Papers on International Economics and Finance DEFI 1107 October 2011 Sustainability of external imbalances in the OECD countries

In this paper, we provide a test of the sustainability of external imbalances in the OECD countries, over the years 1970-2007. Specifically, we deal with the case of those countries that have experienced current account deficits in more than half of the years throughout the period of analysis, and address the recent critique of Bohn (2007) on unit root and cointegration tests of the intertemporal budget constraint. JEL classification: F32, F41.
Management of melioidosis

Melioidosis is a serious human infection caused by the environmental Gram-negative bacterium Burkholderia pseudomallei. Outcome following melioidosis remains poor despite 20 years of clinical research. Overall mortality is 50% in north-east Thailand (35% in children) and 19% in Australia. Relapse is common (13% over 10 years), and results from failure to eradicate the organism. Treatment is required to complete 12–20 weeks, or longer if clinically indicated. This is divided into intravenous and oral phases. Clinical trial evidence supports the use of ceftazidime or a carbapenem antibiotic for initial parenteral therapy, which should be administered for at least 10–14 days. This is followed by a prolonged course of oral antimicrobial therapy with trimethoprim–sulfamethoxazole (TMP–SMX) with or without doxycycline. Amoxicillin–clavulanate is an alternative for children, pregnant women and for patients with intolerance to first-line therapy. Resistance of B. pseudomallei to these drugs is rare, with the exception of TMP–SMX; resistance rates are approximately 2.5% in Australia and 13–16% in Thailand. There is a lack of evidence for the value of adjunctive therapies in the treatment of melioidosis. Future studies aim to address whether meropenem is superior to ceftazidime during parenteral therapy, and whether doxycycline is a necessary component of oral treatment.
Power-efficient voltage tunable RF integrated magnetoelectric inductors with FeGaB/Al2O3 multilayer films

This work reports new integrated GHz magnetic inductors based on solenoid structures with FeGaB/Al2O3 multilayer films, which show significantly enhanced inductance and quality factor at GHz frequencies over their air core counterparts. These inductors show excellent high-frequency performance with a wide operation frequency range of DC-2.5GHz, in which the inductance of the integrated magnetic inductors show >100% enhancement compared with that of the same size air core inductor. Voltage tunable magnetoelectric inductors were fabricated with MEMS processing by putting these inductors on 0.5mm thick ferroelectric (011) cut lead magnesium niobate - lead titanate PMN-PT slab, which showed a voltage tunable inductance of >100%. These novel voltage tunable GHz inductors with giant tunable inductance show great promise for applications in radio frequency integrated circuits.
Correlation of Pulmonary Arterial Smooth Muscle Structure and Reactivity during Adaptation to Extrauterine Life

Peripheral pulmonary arteries remodel immediately after birth as pulmonary vascular resistance falls. We hypothesised that there is a link between the response to agonist stimulation and wall structure in early postnatal life. Arteries from fetal, newborn and 14-day-old piglets were mounted on a perfusion myograph. Lumen diameter and smooth muscle cell nuclear positions were recorded after sequential addition of KCl, U46619 and bradykinin. Subsequently, vessels were studied by confocal and transmission electron microscopy. Contractile agonist stimulation caused a greater and faster reduction in lumen diameter in the newborn than at 14 days (p < 0.02) and the distance between cells decreased more in the newborn (p < 0.05). Unstimulated smooth muscle cells changed shape from being rounded in the fetus to fusiform by 14 days, with increasing length/width ratio (p < 0.01). On contraction, length/width ratio decreased most at 14 days (p < 0.01). Extracellular matrix, collagen and elastin, sparse at birth, increased by 14 days. Thus a greater change in lumen diameter in relation to cellular contraction was observed in the newborn than at 14 days and the amount of extracellular matrix within the vessel wall may affect the overall change in lumen diameter.
Diseño de una herramienta de inferencia de esquemas XML

A dia de hoy, XML (Extensible Markup Language) es uno de los formatos mas utilizados para el intercambio y almacenamiento de informacion estructurada en la World Wide Web. Es habitual que las aplicaciones que utilizan archivos XML presupongan en ellos una estructura determinada, pudiendo producirse errores si se intentase emplear documentos que no la cumplan. A fin de poder expresar este tipo de limitaciones y poder verificar que un documento las cumple, se definio en el mismo estandar XML el DTD, si bien pronto se mostro bastante limitado en cuanto a su capacidad expresiva. Es por este motivo que se decidio crear el XML Schema, un lenguaje XML para definir que estructura deben tener otros documentos XML. Contar con un esquema tiene multiples ventajas, siendo la principal de ellas el poder validar documentos contra el para comprobar si su estructura es correcta u otras como la generacion automatica de codigo. Sin embargo, definir una estructura comun a varios documentos XML de una manera optima puede convertirse en una tarea ardua si se hace de manera manual. Este problema puede salvarse contando con una herramienta que automatice el proceso de creacion de dichos XSDs. En este proyecto, desarrollaremos una herramienta en Java que, a partir de una serie de documentos XML de entrada, inferira automaticamente un esquema contra el que validen todos ellos, expresando su estructura de manera completa y concisa. Dicha herramienta permitira elegir varios parametros de inferencia, a fin de que el esquema generado se adapte lo mas posible a los propositos del usuario. Esta herramienta generara tambien una serie de estadisticas adicionales, que permitiran conocer mas informacion sobre los ficheros de entrada.
A Mouse Model of Chronic Pancreatitis Induced by an Alcohol and High Fat Diet

Background/Aims: Study of acute pancreatitis in chemically-induced rodent models has provided useful data; models of alcoholic chronic pancreatitis have not been available in mice. The aim of the present study was to characterize a mouse model of chronic pancreatitis induced solely with an alcohol and high fat (AHF) diet. Methods: Mice were fed a liquid high fat diet containing 6% alcohol as well as a high fat supplement (57% total dietary fat) over a period of five months or as control, normal chow ad libitum. Pain related measures utilized as an index of pain included mechanical sensitivity of the hind paws determined using von Frey filaments and a smooth/rough textured plate. A modified hotplate test contributed information about higher order behavioral responses to visceral hypersensitivity. Mice underwent mechanical and thermal testing both with and without pharmacological treatment with a peripherally restricted μ-opioid receptor agonist, loperamide. Results: Mice on the AHF diet exhibited mechanical and heat hypersensitivity as well as fibrotic histology indicative of chronic pancreatitis. Low dose, peripherally restricted opiate loperamide attenuated both mechanical and heat hypersensitivity. Conclusion: Mice fed an alcohol and high fat diet develop histology consistent with chronic pancreatitis as well as opioid sensitive mechanical and heat hypersensitivity.
Getting paid for what you do.

Reading is a hobby to open the knowledge windows. Besides, it can provide the inspiration and spirit to face this life. By this way, concomitant with the technology development, many companies serve the e-book or book in soft file. The system of this book of course will be much easier. No worry to forget bringing the getting paid for what you do book. You can open the device and get the book by on-line.