Miracle-dz/UniFAR-FTUs huggingface dataset:
Formation of Thin, Isoporous Block Copolymer Membranes by an Upscalable Profile Roller Coating Process—A Promising Way to Save Block Copolymer

In this work we present a method to manufacture flat sheet membranes with a thin isoporous block copolymer (BCP) layer (thickness <3 µm) by profile roller coating (breadth: 30 cm) on top of a porous support membrane. Highly diluted BCP-solutions were used for this coating process. While we cast membranes with dimensions of 30 cm × 50 cm in this work, the procedure can easily be extended to endless dimensions in this roll to roll (R2R) process. The method offers the possibility to save >95% of BCP raw material compared to common doctor blade casting, by strongly decreasing the layer thickness to below 3 µm in combination with a highly open substructure. Additionally, we report a straightforward method to investigate the influence of the solvent evaporation time between coating and precipitation (phase inversion) on the membrane morphology using one sample only, which also ensures that all other influencing parameters remain constant.
Safety and Efficacy of Exenatide Once Weekly Plus Dapagliflozin Once Daily Versus Exenatide or Dapagliflozin Alone in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy: 52-Week Results of the DURATION-8 Randomized Controlled Trial

OBJECTIVE Among patients with type 2 diabetes uncontrolled with metformin, exenatide once weekly (QW) plus dapagliflozin combination produced greater reductions in glycemia, weight, and systolic blood pressure (SBP) at 28 weeks than exenatide QW or dapagliflozin alone (DURATION-8). Here, we investigated the safety and maintenance of efficacy at 52 weeks, after a 24-week extension. RESEARCH DESIGN AND METHODS This phase 3, multicenter, double-blind study randomized adults with type 2 diabetes (with glycated hemoglobin [HbA1c] 8.0–12.0% [64–108 mmol/mol] and on metformin ≥1,500 mg/day) to exenatide QW (2-mg subcutaneous injection) plus once-daily dapagliflozin (10-mg oral tablet), exenatide QW plus oral placebo, or dapagliflozin plus injected placebo. Extension-period P values were nominal. RESULTS Of 1,375 patients screened, 695 were randomized (mean baseline HbA1c 9.3% [78 mmol/mol]); 81.2% completed the study, and 75.3% completed treatment. At 52 weeks, HbA1c reductions were greater with exenatide QW plus dapagliflozin (least squares mean change −1.75% [−19.1 mmol/mol]) versus exenatide QW (−1.38% [−15.1 mmol/mol]; P = 0.006) or dapagliflozin (−1.23% [−13.4 mmol/mol]; P < 0.001); mean HbA1c values were 6.9% (52 mmol/mol), 7.2% (55 mmol/mol), and 7.4% (57 mmol/mol), respectively. Weight and SBP reductions were greater with exenatide QW plus dapagliflozin (−3.31 kg and −4.5 mmHg) versus exenatide QW (−1.51 kg and −0.7 mmHg; both P < 0.001) but similar to those with dapagliflozin (−2.28 kg and −2.7 mmHg; P = 0.057 and P = 0.100, respectively). The exenatide QW plus dapagliflozin regimen was well tolerated with no unexpected safety findings; more patients treated with exenatide QW experienced gastrointestinal and injection site–related adverse events. No major hypoglycemia occurred. CONCLUSIONS Among patients with type 2 diabetes uncontrolled with metformin, exenatide QW plus dapagliflozin provided sustained improvements in glycemia, weight, and SBP over 52 weeks, with no unexpected safety findings.
An Efficient Approach to Learning Chinese Judgment Document Similarity Based on Knowledge Summarization

A previous similar case in common law systems can be used as a reference with respect to the current case such that identical situations can be treated similarly in every case. However, current approaches for judgment document similarity computation failed to capture the core semantics of judgment documents and therefore suffer from lower accuracy and higher computation complexity. In this paper, a knowledge block summarization based machine learning approach is proposed to compute the semantic similarity of Chinese judgment documents. By utilizing domain ontologies for judgment documents, the core semantics of Chinese judgment documents is summarized based on knowledge blocks. Then the WMD algorithm is used to calculate the similarity between knowledge blocks. At last, the related experiments were made to illustrate that our approach is very effective and efficient in achieving higher accuracy and faster computation speed in comparison with the traditional approaches.
Collaborative Multi-Robot Transportation in Obstacle-Cluttered Environments via Implicit Communication

This paper addresses the problem of cooperative object transportation in a constrained workspace involving static obstacles, with the coordination relying on implicit communication established via the commonly grasped object. In particular, we consider a decentralized leader-follower architecture for multiple mobile manipulators, where the leading robot, which has exclusive knowledge of both the object's desired configuration and the position of the obstacles in the workspace, tries to navigate the overall formation to the desired configuration while at the same time it avoids collisions with the obstacles. On the other hand, the followers estimate the object's desired trajectory profile via novel prescribed performance estimation laws that drive the estimation errors to an arbitrarily small predefined residual set. Moreover, a navigation function-based scheme is innovatively combined with adaptive control to deal with parametric uncertainty. Hence, the current state of the art in robust motion planning and collision avoidance is extended by studying second order non-linear dynamics with parametric uncertainty. Furthermore, the feedback relies exclusively on each robot's force/torque, position as well as velocity measurements and no explicit information is exchanged online among the robots, thus reducing the required communication bandwidth and increasing robustness. Finally, two simulation studies clarify the proposed methodology and verify its efficiency.
The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies

Background HIV posttreatment controllers are rare individuals who start antiretroviral therapy (ART), but maintain HIV suppression after treatment interruption. The frequency of posttreatment control and posttreatment interruption viral dynamics have not been well characterized. Methods Posttreatment controllers were identified from 14 studies and defined as individuals who underwent treatment interruption with viral loads ≤400 copies/mL at two-thirds or more of time points for ≥24 weeks. Viral load and CD4+ cell dynamics were compared between posttreatment controllers and noncontrollers. Results Of the 67 posttreatment controllers identified, 38 initiated ART during early HIV infection. Posttreatment controllers were more frequently identified in those treated during early versus chronic infection (13% vs 4%, P < .001). In posttreatment controllers with weekly viral load monitoring, 45% had a peak posttreatment interruption viral load of ≥1000 copies/mL and 33% had a peak viral load ≥10000 copies/mL. Of posttreatment controllers, 55% maintained HIV control for 2 years, with approximately 20% maintaining control for ≥5 years. Conclusions Posttreatment control was more commonly identified amongst early treated individuals, frequently characterized by early transient viral rebound and heterogeneous durability of HIV remission. These results may provide mechanistic insights and have implications for the design of trials aimed at achieving HIV remission.
A Heuristic for relative Perception Accuracy and Reaction Time Estimation for HMI Designs

A human operator monitoring a safety-critical system has to gather information fast and accurate to detect problems and execute countermeasures in time. So far testing such HMIs is a complex task, since it requires HMI design prototypes embedded into simulated environments to perform tests with professional operators. We propose Konect Value, a heuristic to estimate the relative perception accuracy and operator reaction time already in the HMI design phase. The model-based estimation heuristic solely requires a task model and HMI design sketches as an input. The evaluation metric was applied to seven different HMIs, which were designed by Human Factor experts to support truck platooning. A comparison of the estimated accuracy and reaction times of Konect Value to a lab study (n=33) revealed high correlations for the relative reaction time (r=0.83, p<0.05) and also the relative perception accuracy (r=-0.90, p<0.01). This indicates that Konect Value is a promising heuristic for early HMI design evaluation in the safety-critical system domain.
OsABCG9 Is an Important ABC Transporter of Cuticular Wax Deposition in Rice

The importance of the cuticular layer in regulating a plant’s water status and providing protection from environmental challenges has been recognized for a long time. The cuticular layer in plants restricts non-stomatal water loss and protects plants against damage from pathogen infection and UV radiation. Much genetic and biochemical research has been done about cutin and wax transportation in Arabidopsis thaliana, but little is known about it in rice. Here, we report that a rice ATP-binding cassette (ABC) transporter, OsABCG9, is essential for normal development during vegetative growth and could play a critical role in the transportation of epicuticular wax in rice. Rice phenotypes with mutated OsABCG9 exhibited growth retardation and sensitivity to low humidity. The total amount of cuticular wax on the leaves of the osabcg9-1 mutant diminished by 53% compared with the wild type, and wax crystals disappeared completely in osabcg9-2 mutant leaves. However, OsABCG9 does not seem to be involved in cutin transportation, even though its ortholog in Arabidopsis, AtABCG11, transports both wax and cutin. Furthermore, the osabcg9-1 mutant had increased leaf chlorophyll leaching and more severe drought susceptibility. This study provides new insights about differences between rice and A. thaliana in wax and cutin transportation associated with the ABCG family during evolution.
Treatise on Materials Science and Technology

H Herman (ed) New York: Academic Press 1973 pp xi + 398 price $28 This volume contains four contributions: 'Epitaxial interfaces' by J H van der Merwe surveys at length lattice mismatch and dislocation formation, but with hardly any mention of real dimensions in real systems. It is therefore not too helpful for the crystal grower seeking understanding.
Phenolic Compounds Isolated from Olive Oil as Nutraceutical Tools for the Prevention and Management of Cancer and Cardiovascular Diseases

Non-communicable diseases (NCDs) have become the largest contributor to worldwide morbidity and mortality. Among them, cancer and cardiovascular diseases (CVDs) are responsible for a 47% of worldwide mortality. In general, preventive approaches modifying lifestyle are more cost-effective than treatments after disease onset. In this sense, a healthy diet could help a range of NCDs, such as cancer and CVDs. Traditional Mediterranean Diet (MD) is associated by the low-prevalence of certain types of cancers and CVDs, where olive oil plays an important role. In fact, different epidemiological studies suggest that olive oil consumption prevents some cancers, as well as coronary heart diseases and stroke incidence and mortality. Historically, the beneficial health effects of virgin olive oil (VOO) intake were first attributed to the high concentration of monounsaturated fatty acids. Nowadays, many studies indicate that phenolic compounds contained in olive oil have positive effects on different biomarkers related to health. Among them, phenolic compounds would be partially responsible for health benefits. The present work aims to explore, in studies published during the last five years, the effects of the main phenolic compounds isolated from olive oil on different cancer or CVD aspects, in order to clarify which compounds have more potential to be used as nutraceuticals with preventive or even therapeutic properties.
Steroid Use for Sudden Sensorineural Hearing Loss: A CHEER Network Study

Objective The objective of this study was to describe patterns of corticosteroid treatment for sudden sensorineural hearing loss and to evaluate effectiveness based on delivery mode (oral vs intratympanic vs both). Study Design Cross-sectional repeated measures. Setting Patients were recruited from practices within the Creating Healthcare Excellence through Education and Research (CHEER) Network. CHEER is a National Institutes of Health–funded nationwide network of 30 community and academic otolaryngology practice sites. Subjects and Methods A subset of 117 patients who had been treated with steroids for sudden sensorineural hearing loss were recruited from within a larger initial CHEER Network study on clinical practice guideline compliance. Outcomes included audiometric and speech scores and patient-perceived improvement. Descriptive analyses, Wilcoxon rank-sum tests, and Fisher exact tests were run. Results Two categories (oral and simultaneous oral + intratympanic) had adequate sample sizes to support statistical comparison of treatment results. Improvements were seen in both audiometry and speech testing scores; 57% of patients self-reported improvement perceived as either minor or major. There were no significant differences in degree of improvement between these treatment groups. Conclusions We observed that a majority of steroid-treated patients demonstrated hearing improvement, but this improvement did not meet criteria for statistical significance. As in other studies on this topic, the relatively small sample size may have prevented differentiation of effectiveness among steroid treatments. We propose that the use of alternative approaches, such as pragmatic clinical trials and multidisciplinary electronic health record systems and megadatabases, may hold the most promise for an approach to best practice development.
Virtual Network Isolation: Are We There Yet?

While multi-tenant cloud computing provides great benefits in terms of resource sharing, it introduces a new security landscape and requires strong network isolation guarantees between the tenants. Such network isolation is typically implemented using network virtualization: Virtual switches residing in the virtualization layer enforce isolation, e.g., via tunnel protocols and per-tenant flow rules. The design of such switches is a very active topic: Since 2009 alone, at least 22 different designs have been introduced. Our systematic analysis of 22 virtual switches uncovers 4 security weaknesses: Co-location, single point of failure, privileged packet processing and manual packet parsing. An attacker can easily undermine network isolation by exploiting those weaknesses. Hence, we introduce 3 secure design principles to build a resilient virtual switch, thereby offering strong virtual network isolation.
Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b

Comprised of telomeric TTAGGG repeats and shelterin, telomeres ensure that the natural ends of chromosomes remain impervious to the DNA damage response. Telomeres carry a long constitutive 3′ overhang that can bind replication protein A (RPA) and activate the ATR Ser/Thr kinase (ATR), which induces cell cycle arrest. A single-stranded (ss) TTAGGG repeat–binding protein in mouse shelterin, POT1a, has been proposed to repress ATR signaling by preventing RPA binding. Repression of ATR at telomeres requires tethering of POT1a to the other shelterin subunits situated on the double-stranded (ds) telomeric DNA. The simplest model of ATR repression, the “tethered exclusion model,” suggests that the only critical features of POT1a are its connection to shelterin and its binding to ss telomeric DNA. In agreement with the model, we show here that a shelterin-tethered variant of RPA70 (lacking the ATR recruitment domain) can repress ATR signaling at telomeres that lack POT1a. However, arguing against the tethered exclusion model, the nearly identical POT1b subunit of shelterin has been shown to be much less proficient than POT1a in repression of ATR. We now show that POT1b has the intrinsic ability to fully repress ATR but is prevented from doing so when bound to Ctc1, Stn1, Ten1 (CST), the complex needed for telomere end processing. These results establish that shelterin represses ATR with a tethered ssDNA-binding domain that excludes RPA from the 3′ overhang and also reveal an unexpected effect of CST on the ability of POT1b to repress ATR.
The global burden and epidemiology of invasive non-typhoidal Salmonella infections

ABSTRACT Invasive non-typhoidal Salmonella (iNTS) disease has emerged as a major public health concern. Yet, understanding of the global burden is incomplete, limited particularly by the breadth of blood culture-based surveillance systems that are able to accurately diagnose the etiology of bacteremia. The accessibility of whole genome sequencing has allowed for genetic characterization of pathogens, shedding light on its evolutionary history and sounding alerts for its future progression. iNTS disease is observed to be a particular threat in sub-Saharan Africa, with a case fatality rate greatly exceeding that of typhoid fever, and commonly affecting infants, young children and immunocompromised adults. While iNTS disease might also be a threat in Asia and Latin America, its burden is not well characterized, primarily owing to the lack of comprehensive reporting in these regions. Drug-resistant Salmonella enterica (S. enterica) serovars (e.g. Typhimurium sequence type 313 (ST313)) have emerged as a potential consequence of sustained antibiotic pressure. Genetic analyses have identified distinguished iNTS disease-causing strains that are particularly virulent in certain human host populations. Effective treatment strategies, including vaccination, are necessary; iNTS vaccines targeting the most common S. enterica serovars, Typhimurium, Enteritidis and Dublin, are currently in early developmental stages. Funding and political support is needed to promote vaccine development and implementation programs to ultimately reduce the threat of iNTS disease in high risk areas.
Immersive previz: VR authoring for film previsualisation

Creatives in animated and real movie productions have been exploring new modalities to visually design filmic sequences before realizing them in studios, through techniques like hand-drawn storyboards, physical mockups or more recently virtual 3D environments. A central issue in using virtual 3D environments is the complexity of content creation tools for non technical film creatives. To overcome this issue, we present One Man Movie, a VR authoring system which enables the crafting of filmic sequences with no prior knowledge in 3D animation. The system is designed to reflect the traditional creative process in film pre-production through stages like (i) scene layout (ii) animation of characters, (iii) placement and control of cameras and (iv) montage of the filmic sequence, while enabling a fully novel and seamless back-and-forth between all stages of the process thanks to real-time engines. This research tool has been designed and evaluated with students and experts from film schools, and should therefore raise a significant interest among Siggraph participants.
Fungal Communities Along a Small-Scale Elevational Gradient in an Alpine Tundra Are Determined by Soil Carbon Nitrogen Ratios

Elevational gradients are associated not only with variations in temperature and precipitation, but also with shifts in vegetation types and changes in soil physicochemical properties. While large-scale elevational patterns of soil microbial diversity, such as monotonic declines and hump-shaped models, have been reported, it is unclear whether within-ecosystem elevational distribution patterns exist for soil fungal communities at the small scale. Using Illumina Miseq DNA sequencing, we present a comprehensive analysis of soil fungal diversity and community compositions in an alpine tundra ecosystem at elevations ranging from 2000 to 2500 m on the Changbai Mountain, China. Soil fungal community composition differed among elevations, and the fungal diversity (i.e., species richness and Chao1) increased along elevations. Soil fungal richness was negatively correlated with soil carbon/nitrogen (C/N) ratio, and community composition varied according to the C/N ratio. In addition, the relative abundances of Basidiomycota and Leotiomycetes were similarly negatively correlated with C/N ratio. For functional guilds, our data showed that mycoparasite and foliar epiphyte abundances were also influenced by C/N ratio. These results indicated that soil C/N ratio might be a key factor in determining soil fungal distribution at small-scale elevational gradients.
Disease-free Survival and Local Recurrence for Laparoscopic Resection Compared With Open Resection of Stage II to III Rectal Cancer: Follow-up Results of the ACOSOG Z6051 Randomized Controlled Trial

Objective: To determine the disease-free survival (DFS) and recurrence after the treatment of patients with rectal cancer with open (OPEN) or laparoscopic (LAP) resection. Background: This randomized clinical trial (ACOSOG [Alliance] Z6051), performed between 2008 and 2013, compared LAP and OPEN resection of stage II/III rectal cancer, within 12 cm of the anal verge (T1-3, N0-2, M0) in patients who received neoadjuvant chemoradiotherapy. The rectum and mesorectum were resected using open instruments for rectal dissection (included hybrid hand-assisted laparoscopic) or with laparoscopic instruments under pneumoperitoneum. The 2-year DFS and recurrence were secondary endpoints of Z6051. Methods: The DFS and recurrence were not powered, and are being assessed for superiority. Recurrence was determined at 3, 6, 9, 12, and every 6 months thereafter, using carcinoembryonic antigen, physical examination, computed tomography, and colonoscopy. In all, 486 patients were randomized to LAP (243) or OPEN (243), with 462 eligible for analysis (LAP = 240 and OPEN = 222). Median follow-up is 47.9 months. Results: The 2-year DFS was LAP 79.5% (95% confidence interval [CI] 74.4–84.9) and OPEN 83.2% (95% CI 78.3–88.3). Local and regional recurrence was 4.6% LAP and 4.5% OPEN. Distant recurrence was 14.6% LAP and 16.7% OPEN. Disease-free survival was impacted by unsuccessful resection (hazard ratio [HR] 1.87, 95% CI 1.21–2.91): composite of incomplete specimen (HR 1.65, 95% CI 0.85–3.18); positive circumferential resection margins (HR 2.31, 95% CI 1.40–3.79); positive distal margin (HR 2.53, 95% CI 1.30–3.77). Conclusion: Laparoscopic assisted resection of rectal cancer was not found to be significantly different to OPEN resection of rectal cancer based on the outcomes of DFS and recurrence.
Abstract depiction of human and animal figures: examples from two centuries of art and craft

The human figure is important in art. I discuss examples of the abstract depiction of the human figure and the challenge faced in algorithmically mimicking what human artists can achieve. The challenge lies in the human brain having enormous knowledge about the world and an ability to make fine distinctions about other humans from posture, clothing and expression. This allows a human to make assumptions about human figures from a tiny amount of data, and allows a human artist to take advantage of this when creating art. We look at examples from impressionist painting, cross-stitch, knitting, pixelated renderings in early video games, and the stylisation used by the artists of children's books.