Miracle-dz/UniFAR-FTUs huggingface dataset:
Bilateral Hypoperfusion and Normal Diffusion MR Images in a Case of Acute Embolic Stroke

Christina Iosif a , C. Oppenheim a , C. Lamy b , J.L. Mas b , J.F. Meder a Universite Paris Descartes, Departments of a Neuroradiology and b Neurology, Sainte-Anne Hospital, Paris , France bleeding was seen, apart from a left parietal microbleed. DWI was normal while apparent diffusion coefficient (ADC) maps revealed a small region of ADC restriction (20%) in the left deep MCA territory. Bolus tracking perfusion-weighted images (PWI) showed bilateral large abnormally perfused areas: (1) in the left MCA territory (mean transit time = 133%, cerebral blood flow = 56% of normal-appearing right frontal area), corroborating the neurological deficit, and (2) in the right temporo-occipital region (mean transit time = 126%, cerebral blood flow = 54%) ( fig. 1 ). After MRI completion, global aphasia persisted (National Institute of Health Stroke Scale score = 5) and the heart rate was irregular. The laboratory tests were normal. Based on the expected language handicap in case of infarct completion and on the presence of at-risk tissue in the contralateral hemisphere, intravenous thrombolysis (6 mg of rt-PA bolus followed by infusion of 52 mg of rt-PA in 1 h) was initiated 160 min after onset. Follow-up MRI showed recanalization of the left MCA and bilateral regression of early vessel signs on FLAIR. The carotid occlusion persisted. A left deep MCA infarct and a right small insular infarct were visible, without cerebral bleeding. The language deficit progressiveA 56-year-old man with a history of paroxysmal atrial fibrillation was referred for sudden mutism and right hemiplegia. Improvement of the motor deficit occurred during transportation. Brain MRI 100 min after onset showed hyperintense middle cerebral artery (MCA) branches bilaterally on FLAIR sequence, and T 2 * hypointensities in the M1 segment of the left MCA and in a right insular branch corresponding to fresh thrombi. MR angiography revealed a left carotid and M1 occlusion. No parenchymal
A program-driven parallel machine simulation environment

In recent years, it has been very popular to employ discrete-event simulation as a hardware architecture analytical tool to study distributed-memory multicomputers and shared-memory multiprocessors. After the hardware architecture prototype has been completed, a complete and detailed machine simulation environment can be utilized to evaluate the architecture's efficiency under real operating systems and application software. In this article, we discuss all the development and implementation of a program-executable Transputer network multicomputer as well as 80x86 series multiprocessors, and how they can be operated. On another level, owing to the extreme complexity of the simulated computer systems, parallel discrete-event simulation has also been used to shorten the time of running the simulation. In practice, this simulator can solve problems through a network connection with many workstations. Some of the workstations may be in charge of computing, while others can be responsible for the management of memory, thus making it simpler to establish a parallel machine simulation environment. In addition to providing an environment for programs to execute on it, such a simulator also calculates the time spent in running these programs, so as to evaluate the feasibility for these application programs to run on a hardware system.
An Survey on Energy and Bandwidth Efficiency in Mobile Adhoc Networks

Mobile Adhoc Network (MANET) is a selforganizing network though it does not have any fixed infrastructure so it is called as infrastructure less network. In Mobile Adhoc network the mobile devices are connected by wireless links. The main advantage of the Mobile Adhoc Network (MANET) is mobility it will dynamically change the environment. Nowadays, the MANET users are increased and the applications supported by these networks are also increased. The load balancing is an important issue which was occurred in mobile adhoc network. There are many numbers of protocols are developed under nonuniform load distributions in order to improve the bandwidth, throughput, energy efficiency etc. The aim at this survey paper is energy efficiency and bandwidth efficiency in mobile adhoc networks. Here various approaches are studied and the ideas are presented.
Willingness and Preferences of Nurses Related to Learning With Technology

To what extent are nurses willing to learn with technology-enhanced tools, such as online education, podcasts, webcasts, mobile learning, and realistic simulations? What factors influence their willingness? This article includes a description of a mixed methodology study that addressed these questions. Nurses of all ages indicated a willingness to learn with a variety of technological tools. Primary determinants of willingness were associated with ease of use, familiarity, convenience, and perceived benefit.
Resting-State Network Functional Connectivity Patterns Associated with the Mindful Attention Awareness Scale

Mindfulness refers to attending to moment-to-moment experiences with acceptance and no judgment. Several scales have been developed to quantify different components of mindfulness. The Mindful Attention Awareness Scale (MAAS) is particularly sensitive to trait mindfulness and is proposed to measure the attentional component of mindfulness. The purpose of this study was to identify the neural correlates of the MAAS in four resting-state networks related to attention-the default mode network (DMN), the salience network (SN), and the left and right central executive network (CEN). Thirty-two university students naive to mindfulness completed the MAAS and later underwent a resting-state functional magnetic resonance imaging scan. Resting-state data were analyzed using an independent component analysis; the scores from the MAAS were covaried to the connectivity maps in an analysis of covariance. The results indicate that variations in MAAS scores correlated with variations in functional connectivity patterns in resting-state networks. Specifically, within the SN and CEN, the MAAS was negatively correlated with functional connectivity in the precuneus, even though the precuneus is a key component of the DMN. Negative correlations in the DMN between the MAAS and the insula and negative correlations in the SN between the MAAS and the posterior cingulate cortex were also observed. These results suggest that MAAS scores (1) are correlated with the functional connectivity of several brain structures related to attention and (2) involve cross-network functional connectivity.
Guideline on Periodicity of Examination, Preventive Dental Services, Anticipatory Guidance/Counseling, and Oral Treatment for Infants, Children, and Adolescents.

Background Professional care is necessary to maintain oral health. The AAPD emphasizes the importance of initiating professional oral health intervention in infancy and continuing through adolescence and beyond. The periodicity of professional oral health intervention and services is based on a patient’s individual needs and risk indicators. Each age group has distinct developmental needs to be addressed at specific intervals as part of a comprehensive evaluation. Continuity of care is based on the assessed needs of the individual patient and assures appropriate management of all oral conditions, dental disease, and injuries. The early dental visit to establish a dental home provides a foundation upon which a lifetime of preventive education and oral health care can be built. Anticipatory guidance and counseling are essential components of the dental visit.
Prevalence of enteric bacteria that inhibit growth of enterohaemorrhagic Escherichia coli O157 in humans

Enterohaemorrhagic Escherichia coli O157 (O157) is infectious to humans, particularly children, at very low doses and causes not only haemorrhagic colitis but also other serious symptoms. To investigate an association between intestinal bacterial flora and resistance to such infections, we screened faecal samples for the presence of enteric bacteria that are able to suppress the growth of O157. Samples from 303 individuals, 35 children (aged [les ]6 years) and 268 adults (aged 20–59 years), were examined. Colonies with different appearances on sorbitol MacConkey agar medium were screened for the production of bacteriocins inhibitory for O157 in an overlay agar plate assay. O157-inhibiting strains were isolated from 52 individuals. The prevalence of these bacteria tended to rise with age, and was significantly higher among 40- to 59-year-old adults (23/101, 22·8%) than among children (3/35, 8·6%; P<0·05). To test the hypothesis that these bacteriocin-producing strains contribute to resistance against O157 in human adults, we examined faecal samples of 25 healthy O157 carriers. Inhibitory bacteria were more prevalent among the latter (9/25, 36·0%) than among age-matched subjects who did not carry O157 (49/268, 18·3%). It appears, therefore, that inhibitory bacteria in the human gut may play a role in inhibiting propagation of O157 and/or suppressing expression of virulence factors by this pathogen.
Stepwise assembly of the Nova-regulated alternative splicing network in the vertebrate brain

Novel organismal structures in metazoans are often undergirded by complex gene regulatory networks; as such, understanding the emergence of new structures through evolution requires reconstructing the series of evolutionary steps leading to these underlying networks. Here, we reconstruct the step-by-step assembly of the vertebrate splicing network regulated by Nova, a splicing factor that modulates alternative splicing in the vertebrate central nervous system by binding to clusters of YCAY motifs on pre-RNA transcripts. Transfection of human HEK293T cells with Nova orthologs indicated vertebrate-like splicing regulatory activity in bilaterian invertebrates, thus Nova acquired the ability to bind YCAY clusters and perform vertebrate-like splicing modulation at least before the last common ancestor of bilaterians. In situ hybridization studies in several species showed that Nova expression became restricted to CNS later on, during chordate evolution. Finally, comparative genomics studies revealed a diverse history for Nova-regulated exons, with target exons arising through both de novo exon creation and acquisition of YCAY motifs by preexisting exons throughout chordate and vertebrate history. In addition, we find that tissue-specific Nova expression patterns emerged independently in other lineages, suggesting independent assembly of tissue-specific regulatory networks.
A Comparative Mass Spectrometric Study of Fatty Acids and Metals in Some Seed Extracts

A major cause of cardiovascular diseases and cancer is diet content, so optimization of micronutrients in food is very important. Omega-3 fatty acids supplementation for patients has beneficial effects on subjective global assessment score and metabolic profiles. Fatty acid content and the metal ions in different seeds (linseed, poppy, grape, hemp, nuts, pumpkin, sesame, watermelon, chia) recommended as food supplements and purchased on the Romanian market, were compared. Gas chromatography coupled to mass spectrometry was used for fatty acid identification and quantitation, and inductively coupled plasma mass spectrometry for analytical measurements of metals.
Blood in schlemm's canal in glaucoma suspects. A study of the relationship between blood-filling pattern and outflow facility in ocular hypertension.

The blood filling of Schlemm's canal was studied in 44 patients with open chamber angles who had experienced ocular hypertensive episodes but suffered no visual damage. The findings were compared with tonographic data. A majority of those with normal blood filling in both eyes were relatively young (mean age ±54.7) and showed good outflow facilities (mean C, 0.26 ± 0.078); those with abnormal filling in one eye only were relatively old (mean age, 60.37) and showed poor outflow facilities (mean C, 0.186 ± 0.041); and, those with abnormal filling in both eyes were even older (mean age, 69.94) and also showed poor outflow facilities (mean C, 0.18 ± 0.051). The applanation pressures did not vary significantly between the three groups of individuals.
Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron

ATP stimulates nociceptive neurons via an action on ligand-gated ion channels. Since tissue injury and inflammation result in both localized acidosis and release of ATP, we studied the effect of acid pH on ATP-gated ion channels in rat nodose ganglion neurons. Lowering pH dramatically increased membrane depolarization and action potential firing elicited by ATP. ATP-activated current was enhanced by acid pH and suppressed by alkaline pH. A pH of 7.2 produced the half-maximal effect. Acidification increased the apparent affinity of the receptor for ATP, as evidenced by a parallel shift of the ATP concentration-response curve to the left. The observations suggest that the localized acidosis associated with tissue injury may enhance pain perception via an action on ATP-gated ion channels on mammalian sensory neurons.
Leishmania Plasma Membrane Mg2+-ATPase Is a H+/K+-Antiporter Involved in Glucose Symport

Experiments from other laboratories conducted with Leishmania donovani promastigote cells had earlier indicated that the plasma membrane Mg2+-ATPase of the parasite is an extrusion pump for H+. Taking advantage of the pellicular microtubular structure of the plasma membrane of the organism, we report procedures for obtaining sealed ghost and sealed everted vesicle of defined polarity. Rapid influx of H+into everted vesicles was found to be dependent on the simultaneous presence of ATP (1 mm) and Mg2+ (1 mm). Excellent correspondence between rate of H+ entry and the enzyme activity clearly demonstrated the Mg2+-ATPase to be a true H+ pump. H+ entry into everted vesicle was strongly inhibited by SCH28080 (IC50 = ∼40 μm) and by omeprazole (IC50 = ∼50 μm), both of which are characteristic inhibitors of mammalian gastric H+,K+-ATPase. H+ influx was completely insensitive to ouabain (250 μm), the typical inhibitor of Na+,K+-ATPase. Mg2+-ATPase activity could be partially stimulated with K+ (20 mm) that was inhibitable (>85%) with SCH28080 (50 μm). ATP-dependent rapid efflux of 86Rb+ from preloaded vesicles was completely inhibited by preincubation with omeprazole (150 μm) and by 5,5′-dithiobis-(2-nitrobenzoic acid) (1 mm), an inhibitor of the enzyme. Assuming Rb+ to be a true surrogate for K+, an ATP-dependent, electroneutral stoichiometric exchange of H+ and K+ (1:1) was established. Rapid and 10-fold active accumulation of [U-14C]2-deoxyglucose in sealed ghosts could be observed when an artificial pH gradient (interior alkaline) was imposed. Rapid efflux of [U-14C]d-glucose from preloaded everted vesicles could also be initiated by activating the enzyme, with ATP. Taken together, the plasma membrane Mg2+-ATPase has been identified as an electroneutral H+/K+ antiporter with some properties reminiscent of the gastric H+,K+-ATPase. This enzyme is possibly involved in active accumulation of glucose via a H+-glucose symport system and in K+accumulation.
Flow cytometric DNA‐ploidy analysis of synchronously occurring multiple malignant tumors of the female genital tract

In this study the authors applied flow cytometric DNA‐ploidy analysis to multiple female genital tract malignant tumors in 43 patients, most of whom (n = 37) had bilateral ovarian cancer. An algorithm was developed for calculation of the likelihood ratio of the probabilities that measured DNA index differences between multiple tumor localizations within the same patient could be attributed to measurement variation or to true biologic DNA content differences. The results of this statistical analysis show that in 72% of the cases (31 of 43) this probability ratio exceeded 1. Because the probability that two independent tumors will have a near‐identical aneuploid DNA content is very low, this finding supports a metastatic process rather than the occurrence of multiple primary tumors in these patients. Thus, flow cytometric DNA‐ploidy analysis can be helpful in the identification of metastatic disease in patients with multiple female genital tract malignant tumors.
Two-Sided Silicon Nanowire Array/Bulk Thermoelectric Power Generator

To improve the output power of n-and p-type Si nanowire array (NWA)/bulk thermoelectric power generators (TEGs) fabricated using metal assisted chemical etching, post-nanowire-etch spin-on-doping (SOD), and arrays on both sides of the bulk are used. Post-process SOD increases the power factor and removes surface depletion/inversion effects while maintaining crystalline NWs. A maximum output power of 3.5 μW for a p-NWA/bulk/NWA TEG with NWA length of 23 and 24 μm is obtained for an external temperature difference of 37 °C and a TEG area of 25 mm2.
Bone marrow angiogenesis and its clinical correlates in myelofibrosis with myeloid metaplasia.

BACKGROUND AND OBJECTIVES Previous retrospective studies have indicated markedly increased bone marrow angiogenesis (BMA) in myelofibrosis with myeloid metaplasia (MMM). This issue is further examined in the current prospective study and clinico-pathological correlates sought. DESIGN AND METHODS This was a prospective single institutional study of 66 patients with bone marrow biopsy-proven MMM who were consecutively accrued. Bone marrow angiogenesis was evaluated by assessing microvessel density through immunohistochemical staining for the CD34 antigen. Laboratory and clinical information was collected concurrently. RESULTS The 66 patients (median age 62 years, 46 males) included 36 with fibrotic phase agnogenic myeloid metaplasia (AMM), 6 with cellular phase AMM, 4 with hypocellular variant AMM, 10 with post-polycythemic myeloid metaplasia, and 10 with post-thrombocythemic myeloid metaplasia. Overall, increased BMA was documented in 61 patients (92%). All of the aforementioned sub-categories of MMM were similarly affected in terms of either grade 3 or 4 BMA but differed in the prevalence of grade 4 BMA (25%, 0%, 0%, 10%, and 10%, respectively). In a univariate analysis the only histological feature that significantly correlated with BMA was the degree of megakaryocyte clustering. Among clinical features, increased BMA was significantly associated with younger age of the patient, lower hemoglobin level, intact spleen, and absence of active therapy. On multivariate analysis, only the latter two retained their significance. INTERPRETATION AND CONCLUSIONS The current prospective study confirms the consistent association of BMA with MMM and suggests that the process starts early, is progressive, and might be dampened by both splenectomy and drug therapy. The study also suggests either a megakaryocyte origin or a megakaryocyte effect for the putative angiogenic cytokine.
Commercial Coffee Wastes as Materials for Adsorption of Heavy Metals from Aqueous Solutions

This work aims to study the removal of Cu(II) and Cr(VI) from aqueous solutions with commercial coffee wastes. Materials with no further treatment such as coffee residues from café may act as adsorbents for the removal of Cu(II) and Cr(VI). Equilibrium data were successfully fitted to the Langmuir, Freundlich and Langmuir-Freundlich model (L-F). The maximum adsorption capacity of the coffee residues can reach 70 mg/g for the removal of Cu(II) and 45 mg/g for Cr(VI). The kinetic data were fitted to pseudo-first, -second and -third order equations. The equilibrium was achieved in 120 min. Also, the effect of pH on adsorption and desorption was studied, as well as the influence of agitation rate. Ten cycles of adsorption-desorption were carried out revealing the strong reuse potential of these low-cost adsorbents; the latter was confirmed from a brief economic approach.
Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies

The prevalence of hepatitis B virus (HBV) infection in patients with haematological malignancies is increased compared with the general population worldwide. HBV reactivation is common following chemotherapy and is associated with a high mortality despite prompt anti‐viral treatment. HBV reactivation may necessitate interruption of chemotherapy with adverse prognostic consequences for the haematological disease. Chemotherapy‐induced immune suppression may lead to increased HBV replication. Immune reconstitution within the weeks and months following recovery from chemotherapy may be associated with a flare of hepatitis B manifested by hepatocellular injury. Risk factors associated with HBV reactivation include detectable hepatitis B surface antigen (HBsAg), HBV DNA, Hepatitis B e (HBeAg) antigen, antibodies to hepatitis B core antigen (anti‐HBc), treatment with corticosteroids, young age and male gender. Lamivudine is effective during HBV reactivation due to immune suppression. Clinical trials have demonstrated that pre‐emptive antiviral treatment with lamivudine is superior to deferred treatment. Current recommendations emphasise screening for HBV infection in all haematology patients, particularly prior to chemotherapy. Patients who are HBsAg positive or HBV DNA positive should receive pre‐emptive treatment with lamivudine before chemotherapy. The duration of lamivudine treatment may be prolonged commensurate with the degree of immunosuppression. HBV naïve patients should be immunised against hepatitis B, as should haematopoietic stem cell donors. In summary, overt and occult HBV pose a serious, but preventable, threat. Pre‐treatment screening of patients at risk should be practiced diligently by all clinicians that treat patients with malignancies.
Structural and Functional Impact of Parkinson Disease‐Associated Mutations in the E3 Ubiquitin Ligase Parkin

Mutations in the PARKIN/PARK2 gene that result in loss‐of‐function of the encoded, neuroprotective E3 ubiquitin ligase Parkin cause recessive, familial early‐onset Parkinson disease. As an increasing number of rare Parkin sequence variants with unclear pathogenicity are identified, structure–function analyses will be critical to determine their disease relevance. Depending on the specific amino acids affected, several distinct pathomechanisms can result in loss of Parkin function. These include disruption of overall Parkin folding, decreased solubility, and protein aggregation. However pathogenic effects can also result from misregulation of Parkin autoinhibition and of its enzymatic functions. In addition, interference of binding to coenzymes, substrates, and adaptor proteins can affect its catalytic activity too. Herein, we have performed a comprehensive structural and functional analysis of 21 PARK2 missense mutations distributed across the individual protein domains. Using this combined approach, we were able to pinpoint some of the pathogenic mechanisms of individual sequence variants. Similar analyses will be critical in gaining a complete understanding of the complex regulations and enzymatic functions of Parkin. These studies will not only highlight the important residues, but will also help to develop novel therapeutics aimed at activating and preserving an active, neuroprotective form of Parkin.