Miracle-dz/UniFAR-FTUs huggingface dataset:
EARLY ATHEROSCLEROTIC CHANGES IN HIPOPITUITARY PATIENTS WITH GROWTH HORMONE DEFICIENCY

ABSTRACT Objective: Cardiovascular diseases have been implicated in excess mortality in adult hypopituitary patients (HP) who do not receive growth hormone (GH) replacement. GH deficiency induces a proatherogenic state. In this study we aimed to investigate endothelial function and early atherosclerotic changes in GH-deficient HP. Material and methods: Endothelial function was assessed by flow mediated dilation (FMD) of the brachial artery. Demographic, anthropometric, endocrine and biochemical findings, brachial artery FMD and carotid artery intima-media thickness (IMT) were recorded. Results: Nineteen HP not receiving GH (9 women, age: 42±16 years) and 19 healthy controls (6 women, age: 39±16 years) were enrolled. In HP, the waist circumference (94.5±13.2 cm vs. 86.8±8.7 cm, p=0.04), and the body fat mass (%) were found higher(30.9±9.1 vs. 23.8±8.6, p=0.02), the lean body mass (%) was found lower (69.0±9.1 vs. 76.1±8.6, p=0.01). The carotid artery IMT was higher (0.80±0.22 vs. 0.56±0.25, p=0.01) and the brachial artery FMD was lower (8.8±6.06 vs. 13.5±4.6, p=0.02) in HP compared to healthy controls. There was a significant correlation between patient age and carotid artery IMT in both groups; the association was more prominent in the patient group (r=0.8624 p<0.001 for patients, r=0.7859 p=0.001 for controls). Conclusion: The decreased FMD in the GH-deficient HP established the endothelial dysfunction. The relationship between carotid artery IMT and age was more prominent in the hypopituitary group. Our findings suggest that endothelial function is impaired in HP and the effects of aging on atherosclerosis appear in a more pronounced way in HP. Key words: Hipopituitarism, growth hormone deficiency, endothelial function
Extracting 3D Maps from Crowdsourced GNSS Skyview Data

3D maps of urban environments are useful in various fields ranging from cellular network planning to urban planning and climatology. These models are typically constructed using expensive techniques such as manual annotation with 3D modeling tools, extrapolated from satellite or aerial photography, or using specialized hardware with depth sensing devices. In this work, we show that 3D urban maps can be extracted from standard GNSS data, by analyzing the received satellite signals that are attenuated by obstacles, such as buildings. Furthermore, we show that these models can be extracted from low-accuracy GNSS data, crowdsourced opportunistically from standard smartphones during their user's uncontrolled daily commute trips, unleashing the potential of applying the principle to wide areas. Our proposal incorporates position inaccuracies in the calculations, and accommodates different sources of variability of the satellite signals' SNR. The diversity of collection conditions of crowdsourced GNSS positions is used to mitigate bias and noise from the data. A binary classification model is trained and evaluated on multiple urban scenarios using data crowdsourced from over 900 users. Our results show that the generalization accuracy for a Random Forest classifier in typical urban environments lies between 79% and 91% on 4 m wide voxels, demonstrating the potential of the proposed method for building 3D maps for wide urban areas.
Demo: A ROS-based Robot with Distributed Sensors for Seamless People Tracking

This paper presents a robot for people identification and tracking developed on robot operating system (ROS). It achieves modulized, light-weight, low-cost, and high-performance design goals even with the existence of distributed sensors. The key idea is to utilize wearable devices to enhance the people tracking capability of a robot through instant wireless communications and multi-sensory data fusion. Experimental results in a realistic environment demonstrate that our robot can keep tracking a specific person at a safe distance even without seeing the biological features of the person, who walks in a crowd with complex trajectories.
Risk Factors For Neonatal Mortality In A Regional Tertiary Hospital In Nigeria

Objective: To determine the causes of neonatal mortality in a referral centre in Nigeria with a view to developing strategies that will help in reducing it. Methods: This is a retrospective patient record review of the records of 166 infants that died in the newborn unit between 1998 when the unit was established and April 2001. Results: During the study period of 38 months, the mortality was 166 (19.4%) out of a total of 854 admissions. Prematurity, birth asphyxia and sepsis topped the list of causes of death with 30.7%, 24.1%, and 19.3% respectively while postmaturity and intrauterine growth restriction (IUGR) were least with 1.2% each respectively. Conclusions: To reduce this magnitude of mortality among this group of babies there is need to establish more centres with trained personnel that will offer optimal management for the high-risk pregnancies and strategies to reduce the incidence of prematurity and low birth weight babies must be instituted. Nigerian Journal of Clinical Practice Vol. 7(2) 2004: 50-52
EXPERIMENTAL RICKETS IN RATS

Young rats on a diet low in phosphorus can be protected from rickets by irradiations with sunlight for about 15 minutes daily. In the winter months, however, this degree of light was found insufficient. The effective rays of the sun, in the intensities studied, did not penetrate window glass. They manifested some protective value after reflection from a smooth white surface. Irradiation of a few minutes with the rays of the mercury vapor lamp suffices to protect rats against rickets. This is true likewise of the rays from the carbon arc lamp. A standard protective dose of radiation can be formulated for rats on a standard diet. Light is able to prevent the occurrence of rickets in rats fed a rickets-producing diet characterized either by a low phosphorus and high calcium content, or a high phosphorus and low calcium content. Moderate variations in temperature do not alter the effective action of light rays. Pigmentation of the skin markedly lessens their effect, as demonstrated by the failure of a standard dose to protect black rats.
Le corps comme objet de l'interaction médecin-patient

Distribution électronique Cairn.info pour Dilecta. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit. Article disponible en ligne à l’adresse https://www.cairn. info/revue-corps-dilecta-2009-1-page-69.htm
STUDIES ON EXPERIMENTAL RICKETS.

Diet 4025. Diet 4026. Wheat germ. 5.0 Wheat germ . 5.0 Salt mixture 37. 5.15 Salt mixture 38 . 4.3 CaC03. 1.5 CaC03. 1.5 Gelatin. lO.O Casein. 20.0 Egg albumen. lO.O Gelatin . 5.0 Wheat gluten. 12.0 Wheat gluten . 5.0 Agar-agar. 2.0 Agar-agar . 2.0 Dextrin. 49.35 Dextrin.52. 2 Butter fat. 5.0 Butter fat . 5.0
Towards seamless interfacing between dynamic languages and native code

Existing approaches to interfacing high- and low-level code push considerable burdens onto the programmer, such as wrapper maintenance, explicit code generation, interface re-declaration, and/or signalling to garbage collectors. We note that run-time information on data layout and allocations in native code is available, and may be extended with knowledge of object lifetimes to assist in automating garbage collection. We describe work in progress towards an extension of the CPython virtual machine along these lines. We report initial experience building a first working prototype, and some early performance experiments.
Road Infrastructure Monitoring System using E-Bikes and Its Extensions for Smart Community

In this paper, we present a road infrastructure monitoring system using e-bikes to support smart community. Smartphone and IoT (Internet of Things) devices are attached to e-bikes, and electric power is supplied from the batteries of e-bikes. Image processing techniques based on deep learning are applied and run on IoT devices or cloud backbone. A prototype system is implemented, which performs from image capturing to web browsing of the processed images.
Lazy pointer update for low heap compaction pause times

To keep applications highly responsive, garbage collectors (GCs) try to minimize interruptions of the application threads. While pauses due to non moving GCs can be drastically reduced through concurrent or incremental strategies, compaction pauses remain a big problem. A strategy to decrease stop the world compaction pauses is to compact subsets of the heap at any one time. But this only reduces the time spent in moving compacted objects, not the time spent updating all references to those objects, which may be significant in large heaps. In this paper, we propose to only move compacted objects during the compaction pause, replacing moved objects by low-overhead forwarding objects. References to compacted objects are lazily updated while the application is running and during the next GC marking phase, outside of the compaction pause. We evaluate our technique on a suite of high workload (2 to 14Gb) benchmarks built from a real industrial application. Results show that not updating pointers during the compaction pause decreases the median pause up to 31% and the longest pause up to 71% on these benchmarks, while the forwarding objects slow down execution time without GC by no more than 1%.
GRASS: generic reactive application-specific scheduling

High resource utilization is important to operate compute infrastructures and data centers efficiently. High utilization is achieved by multiplexing several applications over the same physical infrastructure. Yet, with this approach, the different requirements of each application have to be taken into account when scheduling resources. We propose GRASS, a reactive domain-specific abstraction that allows specifying application-tailored resource scheduling policies. We demonstrate how the declarative approach of GRASS enables extension and composition of scheduling policies. Our evaluation shows the performance benefits of considering application-specific information in a composition of scheduling policies that adapt at run time.
The influence of vitamin E bonded haemodialysis membranes on erythropoiesis stimulating agent requirements, oxidative stress, inflammation, haemostasis and outcomes

Introduction: Haemodialysis (HD) patients have high rates of cardiovascular (CV) disease and mortality yet the reasons for this have not been fully elucidated. High doses of erythropoiesis stimulating agents (ESAs), increases in oxidative stress and inflammation, and alterations to the fibrin clot phenotype are all possible contributors. Vitamin E (VE)- bonded dialysis membranes are purported to have favourable effects on a number of these parameters which were tested here in the setting of a randomised controlled trial. Methods: Patients were randomised to HD with VE-bonded polysulfone membranes or non-VE-bonded equivalents and followed for 12 months. Data on anaemia parameters were collected monthly and blood tests were performed at baseline, 6 and 12 months for the measurement of oxidative stress (oxidatively modified-low density lipoprotein, thiobarbituric acid reactive species), inflammation (C-reactive protein, complement components C3, SC5b-9, factor D, properdin) and fibrin clot properties. Contemporaneous data were collected on CV events and death. Results: Of the 260 patients enrolled, 123 were randomised to dialysis with VE-bonded membranes. Analysis of the full dataset revealed no differential effects of the VEmembranes on ESA requirements, oxidative stress, inflammation, fibrin clot structure or clinical outcomes. Key findings included a potential ESA-sparing effect of the VEmembranes in ESA resistant patients, a progressive decline in C3 levels over 12 months and associations between the levels of C3 and SC5b-9 at baseline and the subsequent risks of dying or experiencing a CV event. Conclusions: There were no benefits in switching prevalent HD patients to dialysis with VE-bonded dialysis membranes with the exception of possible utility in ESA-resistant patients. The novel finding suggesting a link between the complement system and poor outcomes in HD patients may provide further insights to explain the high rates of CV disease and mortality for this patient group and merits further study.
A Framework for Queryable Video Analysis: A Case-Study on Transport Modelling

Analysing video data requires the use of different models trained to retrieve or process data for a particular task. In this paper, we introduce an approach to represent the visual context within a video as queryable information. Through the use of computer vision techniques, we can detect and classify objects. Our system processes these classifications in order to construct a queryable data-set referred to as the real world model. The advantage of this approach is that through the formalisation of the information, we can create generic queries to retrieve information. This approach allows for processing to be done on edge devices such as embedded cameras while only transmitting detected information reducing the transmission bandwidth as well as infrastructural costs. The final recognition data is processed on the cloud. The analysed case study works on video traffic representation - an experiment around the transport domain. We evaluate and validate our approach by posing several queries to the system that generates information on the traffic situation, such as car counting and traffic flow. The results show that our approach can add context to classifications with a high degree of accuracy in some of the cases, achieving 95% car counting accuracy during the day. Fine tuning approaches are also discussed with reference to the video traffic representation case while keeping to the same proposed methodology.
Older Adults’ Use of and Attitudes toward Activity Monitoring Technologies

Self-management of health is becoming increasingly important in today’s healthcare climate. Activity monitoring technologies have the potential to support health self-management by tracking, storing, compiling, and providing feedback about an individual’s engagement in movement activities. Older adults represent a fast growing segment of the population who may benefit from such technologies. To understand how to facilitate technology acceptance and adoption, more information is needed about older adults’ attitudes and usage of such technologies. Eight older adult participants (Mage = 65.0 years; SD = 3.2; range = 61-69) used one of four activity monitoring technologies in their own homes for two weeks. Attitudes and usability issues were assessed and evaluated within a technology acceptance framework. Participants’ initial attitudes were positive, but after using the technology for two weeks, attitudes were mixed. Three participants indicated they would continue using the technology, whereas five said they would abandon the technology. These data offer insight into older adults’ use of and attitudes toward activity monitoring technologies and provide improvement opportunities for designers. The results suggest that efforts should focus on conveying the usefulness and personal benefits of activity monitoring technologies specific to older adults.
Deaf Effect for Risk Warnings: A Causal Examination applied to Information Systems Projects

textabstractEscalation of commitment to a chosen course of action is a phenomenon that shows for example when failing strategic Information Systems (IS) projects are continued for much too long. With this study we contribute to the explanation of why managers (Project Owners) respond with the Deaf Effect to Risk Warnings, even when these warnings are provided by a credible messenger, such as an internal auditor. We examine whether the IS Project Owner’s Perceived Control is of influence on the Deaf Effect. We also examine whether the Deaf Effect for the risk warning is affected by the relationship with the messenger: is the messenger seen as a collaborative partner who is of help or is the messenger seen as an opponent who is exposing the Project Owner’s failures. Furthermore, we assess whether the Deaf Effect is affected by the presentation (framing) of the message in terms of Gains or in terms of Losses. Based on experiments we analyze the main effects and the interaction effects of those three factors to the Deaf Effect. In a multi-case study we explore other factors that can affect the Deaf Effect and could be interesting for further study. We discuss the contribution of our study to literature on escalating IS projects and to literature on internal auditing. Finally we discuss the implications of our study to the practice of IS Projects and Internal Auditing and to management practice in general.
EFECTIVIDAD Y EFECTOS SECUNDARIOS DEL TRATAMIENTO CON CANABINOIDES EN DOLOR NEUROPÁTICO DE TIPO CENTRAL EN PACIENTES CON ESCLEROSIS MÚLTIPLE

La Esclerosis Multiple (EM) es una enfermedad neurodesmielinizante de origen inmunologico que afecta a personas entre los 16 a los 35 anos de edad y en la cual del 36% al 82% de los pacientes manifiestan dolor como sintoma comun. La EM tiene una prevalencia mundial de 4,41 por cada 100.000 habitantes, afectando alrededor de 2,5 millones de personas en todo el mundo y cerca de 400.000 en Estados Unidos; en Colombia es de 4,3 por cada 100.000 habitantes, presentandose la mayoria de los casos en Risaralda seguido por Bogota. Los sindromes de dolor neuropatico de tipo central se presentan por lesion o disfuncion del sistema nervioso central, causando discapacidad y deterioro de la calidad de vida de los pacientes. En este articulo se hace una revision sobre la efectividad analgesica y efectos secundarios de los canabinoides en el tratamiento de dolor neuropatico de tipo central en pacientes con EM. Se realizo una estrategia de busqueda identificando ensayos clinicos aleatorizados sobre tratamientos de dolor neuropatico de tipo central en EM con canabinoides y se seleccionaron seis estudios que compararon canabinoides vs placebo. Basados en los articulos revisados se puede concluir, que hay una disminucion significativa del dolor neuropatico de tipo central en pacientes que padecen EM con la administracion de canabinoides y los efectos secundarios son leves, siendo los mas frecuentes vertigo, xerostomia, somnolencia y alteraciones en el equilibrio los cuales no alteran la calidad de vida del paciente.
Physical and Radiobiological Evaluation of Radiotherapy Treatment Plan

Radiation treatment planning plays an important role in modern radiation therapy; it could simulate to plan the geometric, radiobiological, and dosimetric aspects of the therapy using radiation transport simulations and optimization. In this chapter, we have reviewed several quantitative methods used for evaluating radiation treatment plans and discussed some important considering points. For the purpose of quantita‐ tive plan evaluation, we reviewed dosimetrical indexes like PITV, CI, TCI, HI, MHI, CN, COSI, and QF. Furthermore, radiobiological indexes like Niemierko’s EUD-based TCP and NTCP were included for the purpose of radiobiological outcome modeling. Additionally, we have reviewed dose tolerance for critical organs including RTOG clinical trial results, QUENTEC data, Emami data, and Milano clinical trial results. For the purpose of clinical evaluation of radiation-induced organ toxicity, we have re‐ viewed RTOG and EORTC toxicity criteria. Several programs could help for the easy calculation and analysis of dosimetrical plan indexes and biological results. We have reviewed the recent trend in this field and proposed further clinical use of such pro‐ grams. Along this line, we have proposed clinically optimized plan comparison proto‐ cols and indicated further directions of such studies.
Características de la población de roedores y pulgas en áreas de diferente riesgo para peste de tres provincias del departamento de Piura - Perú

Objetivo: Identificar las especies de roedores y pulgas en areas de bajo, mediano y alto riesgo para peste de tresprovincias de Piura, determinando su distribucion geografica y densidad poblacional. Materiales y metodos: En esteestudio transversal analitico se realizaron capturas de roedores y pulgas en 80 localidades de tres provincias de Piura–Peru entre Marzo del 2000 y Febrero del 2001, realizandose la identificacion de sus especies. Las localidades fueronagrupadas en tres areas: bajo, mediano y alto riesgo para peste. Se tomaron muestras de visceras de 382 roedores parael aislamiento de Yersinia pestis, mediante cultivo e inmunofluorescencia directa, y muestras de sangre en tiras de Nobutoa 376 roedores y 286 perros para evaluar la presencia de anticuerpos contra Yersinia pestis, a traves de la prueba deaglutinacion en latex. Se calcularon indicadores de densidad poblacional para roedores y pulgas. Resultados: Akodon sp. (50,4%) y Rattus rattus (32,5%) fueron las especies de roedores predominantes. 23 localidades tuvieron un indice deatrape de roedores (IAR) mayor a 5%. Pulex irritans y Ctenophalides felis fueron las especies de pulgas mas frecuentes.Xenopsilla cheopis solo alcanzo un porcentaje de 0,2%, no encontrandose Polygenes litargus. Los indicadores de densidadpoblacional de pulgas fueron bajos. Todas las muestras para cultivo, inmunofluorescencia y serologia resultaronnegativas. Conclusiones: La poblacion de roedores fue alta en 23 localidades, sin embargo, la densidad poblacional depulgas y la ausencia de circulacion de Yersinia pestis no indican riesgo para la aparicion de brotes de peste.
Abstract S1-06: Stromal tumor-infiltrating lymphocytes(S-TILs): In the alliance N9831 trial S-TILs are associated with chemotherapy benefit but not associated with trastuzumab benefit

Background: Tumor-infiltrating lymphocytes (TILs) at diagnosis are reported to be prognostic in triple-negative breast cancer (BC). Analysis of a small subset of 209 HER2+ patients (pts) with 49 events concluded that higher levels of S-TILs are associated with increased trastuzumab benefit (Loi, 2014). Here we report the largest study to date evaluating S-TILs and their prognostic and predictive association with clinical outcome in N9831 pts treated with either chemotherapy or chemotherapy plus trastuzumab. Methods: Samples assessed were from primary tumors of pts on N9831 arm A (standard AC→T chemotherapy) and arm C (concurrent chemotherapy with trastuzumab) (Perez, 2011). S-TILs were evaluated on HE ≥60% S-TILs was used for the categorical cutoff (Denkert, 2010). The association between S-TILs, treatment (tx) and recurrence-free survival (RFS) was studied and the interaction between S-TILs, trastuzumab benefit and RFS was calculated. Results: 489 pts from arm A (chemo) and 456 pts from arm C (chemo with trastuzumab) were assessed and were similar to pts in the overall trial; all had RFS information and a median follow-up of 4.4yr. Tumors from 54% of pts in arms A and C were HR+; 14% were node-negative. Tumors with high S-TILs were more likely to be hormone receptor-negative (p Conclusions: In exploratory analyses from this subset HER2+ population from N9831, S-TILs were associated with RFS in patients treated with chemotherapy alone, and were not shown to be associated with RFS in patients treated with chemotherapy plus trastuzumab. Citation Format: Edith A Perez, Karla V Ballman, S Keith Anderson, E Aubrey Thompson, Sunil S Badve, Helen Bailey, Frederick L Baehner. Stromal tumor-infiltrating lymphocytes(S-TILs): In the alliance N9831 trial S-TILs are associated with chemotherapy benefit but not associated with trastuzumab benefit [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr S1-06.