Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiovascular Damage Associated With Chest Irradiation

The improvement of anticancer-therapies results in a greater amount of long-term survivors after radiotherapy. Therefore, the understanding of cardiotoxicity after irradiation is of increasing importance. Cardiovascular adverse events after chest irradiation have been acknowledged for a long time but remain difficult to diagnose. Long-term cardiovascular adverse events may become evident years or decades after radiotherapy and the spectrum of potential cardiovascular side effects is large. Recent experimental and clinical data indicate that cardiovascular symptoms may be caused especially by heart failure with preserved ejection fraction, which remains incompletely understood in patients after radiation therapy. Heart radiation dose and co-existing cardiovascular risk factors represent some of the most important contributors for incidence and severity of radiation-induced cardiovascular side effects. In this review, we aim to elucidate the underlying patho-mechanisms and to characterize the development of radiation-induced cardiovascular damage. Additionally, approaches for clinical management and treatment options are presented.
17 Factor Models and Principal Components 17 . 1 Dimension Reduction

High-dimensional data can be challenging to analyze. They are difficult to visualize, need extensive computer resources, and often require special statistical methodology. Fortunately, in many practical applications, high-dimensional data have most of their variation in a lower-dimensional space that can be found using dimension reduction techniques. There are many methods designed for dimension reduction, and in this chapter we will study two closely related techniques, factor analysis and principal components analysis, often called PCA. PCA finds structure in the covariance or correlation matrix and uses this structure to locate low-dimensional subspaces containing most of the variation in the data. Factor analysis explains returns with a smaller number of fundamental variables called factors or risk factors. Factor analysis models can be classified by the types of variables used as factors, macroeconomic or fundamental, and by the estimation technique, time series regression, cross-sectional regression, or statistical factor analysis.
Modelos de Cuidados Paliativos en pacientes con cáncer

espanolLos cuidados paliativos representan la respuesta profesional, cientifica y humana a las necesidades de los pacientes con cancer terminal y sus familias. En Espana se ha producido un rapido crecimiento de la medicina paliativa, existiendo mas de 200 equipos especificos. Se resumen cuatro programas de cuidados paliativos que muestran una fructifera colaboracion entre estos equipos y los Servicios de Oncologia, que en dos de ellos son los impulsores del proyecto. Desde un punto de vista organizativo los cuidados paliativos requieren la combinacion de medidas generales con el desarrollo de equipos de soporte y unidades de hospitalizacion. La formacion avanzada en medicina paliativa precisa una solida base de conocimientos oncologicos. A su vez, se recomienda hacer enfasis en los contenidos de medicina paliativa existentes en el programa de los futuros especialistas en oncologia. Un reto pendiente en oncologia y cuidados paliativos es potenciar la investigacion de aspectos relacionados con la fase terminal. EnglishPalliative care is the human, scientific and profesional response to the needs of terminal cancer patients and their familys. There is in Spain a fast growth of palliative medicine, wiht more than 200 specific teams. We resume diverses programs with a fruitful collaboration between these teams and oncologic departments. Palliative care need the combination of general measures with the implementation of specific support teams and units. Advanced education in palliative medicine requires a solid base of oncologic knowledgement. Furthermore, contents of palliative care should be reinforced in formative programs of future oncologists. Research in terminal care is a challenge.
Delonix Regia Seeds and Pods: Characterization and Its Potential as a Feedstock for Thermochemical Conversion

This study investigated the possibility of using Delonix regia seeds and pods for solid fuel. From the proximate analysis the seed has 5.26 % moisture, 92.54 % volatile matter, 0.34 % fixed carbon with 1.86 % ash content, while 6.29 %, 91.30 %, 0.63 % and 1.78 % were for the pod. The ultimate analysis recorded 40.67 % carbon, 6.44 % hydrogen and 2.14 % sulphur for the seed, while the pod has 45.00 %, 5.61 %,and 1.69 % respectively. The structural analysis revealed that hemicellulose content was higher than the cellulose. The scanning electron microscope revealed the pod as rods like long piles and the seed as an aggregate of the roundish ball. Energy Dispersed X-ray (EDX) recorded the presence of O, Na, Mg, Si, P, Cl, K, Ca and Br. The thermogravimetric analysisrevealed the removal of bond water, degradation of hemicellulose, cellulose, and lignin. The Higher Heating Values using three different formula ranges from 14.19 – 14.49 MJ/Kg. The research indicated that the materials have high volatile matters and higher heating values, with low ash content. Also, the quantity of cellulose, hemicellulose, and lignin is an indication of the plant's suitability for bioenergy production.
Carbon fibers derived from pure alkali lignin fibers through electrospinning with carbonization

Alkali lignin (AL) fibers with a smooth surface and fine morphological appearance were successfully produced via electrospinning using a simple heated single spinneret system, instead of typical electrospinning of lignin with added synthetic polymer blends or conventional co-axial electrospinning. To reduce the size of the fibers, glycerol was added to the spinning solution as a co-solvent for surface tension reduction and electrospinnability improvement. After electrospinning, stabilization and carbonization were subsequently performed to convert AL fibers to carbon fibers (CFs). The obtained CFs displayed rough and uneven surfaces. However, the CFs derived from glycerol-added solution showed greater electrical conductivity, specific surface area, and porosity compared with those from pure AL solution. Furthermore, the results indicated that the inorganic salts on the rough surface of CFs were successfully removed by sulfuric acid (H2SO4) washing. After H2SO4 washing, the CFs revealed a smoother surface and higher electrical conductivity, specific surface area, and porosity.
Aiming at real applications: Subsequence Outlier Detection on Mixed-Type Attributes Data in RDBMS

For many real applications, ranging from traditional management information systems (MIS) to e-commerce and socials web, produce large volumes of sequences of multivariate time-stamped observations. The classical data representation for these applications is an information table stored in RDBMS 1 , in which rows stand for objects and columns denote attributes. Based on the above scenarios, unsupervised subsequence outlier detection on time series data is a valuable problem in practice which helps in saving the cost of labeling and providing interpretability in real applications. This problem is called subsequence outlier detection tasks [2]. In this abstract, we study this issue and show our preliminary analysis and ongoing work.
Content Aware Video Condensation Using Low Cost Ribbon Carving Technique

: The amount of captured video is growing with the increased numbers of video cameras, especially the increase of millions of surveillance cameras that operate 24 hours/day. Since video browsing and retrieval is time consuming, most captured video is never watched or examined. Efficient browsing of long video sequences is a key tool in visual surveillance. Video condensation aims at providing condensed representations of video datasets that can be easily captured from digital cameras. Video condensation, that is proposed here, is novel in the way information is removed from the space-time video volume is conceptually simple and relatively easy to implement. Ribbons are recursively carved out by minimizing an activity-aware cost function. The ribbon model is flexible and permits an easy adjustment of the compromise between temporal condensation ratio and anachronism of events. And also sliding-window ribbon carving is proposed to handle streaming video. Video condensation can be applied to create a synopsis of endless video streams, as generated by webcams and by surveillance cameras.
Contrast versus identity encoding in the face image follow distinct orientation selectivity profiles

Orientation selectivity is a fundamental property of primary visual encoding. High-level processing stages also show some form of orientation dependence, with face identification preferentially relying on horizontally-oriented information. How high-level orientation tuning emerges from primary orientation biases is unclear. In the same group of participants, we derived the orientation selectivity profile at primary and high-level visual processing stages using a contrast detection and an identity matching task. To capture the orientation selectivity profile, we calculated the difference in performance between all tested orientations (0, 45, 90, and 135°) for each task and for upright and inverted faces, separately. Primary orientation selectivity was characterized by higher sensitivity to oblique as compared to cardinal orientations. The orientation profile of face identification showed superior horizontal sensitivity to face identity. In each task, performance with upright and inverted faces projected onto qualitatively similar a priori models of orientation selectivity. Yet the fact that the orientation selectivity profiles of contrast detection in upright and inverted faces correlated significantly while such correlation was absent for identification indicates a progressive dissociation of orientation selectivity profiles from primary to high-level stages of orientation encoding. Bayesian analyses further indicate a lack of correlation between the orientation selectivity profiles in the contrast detection and face identification tasks, for upright and inverted faces. From these findings, we conclude that orientation selectivity shows distinct profiles at primary and high-level stages of face processing and that a transformation must occur from general cardinal attenuation when processing basic properties of the face image to horizontal tuning when encoding more complex properties such as identity.
Identification of Deregulated Pathways, Key Regulators, and Novel miRNA-mRNA Interactions in HPV-Mediated Transformation

Next to a persistent infection with high-risk human papillomavirus (HPV), molecular changes are required for the development of cervical cancer. To identify which molecular alterations drive carcinogenesis, we performed a comprehensive and longitudinal molecular characterization of HPV-transformed keratinocyte cell lines. Comparative genomic hybridization, mRNA, and miRNA expression analysis of four HPV-containing keratinocyte cell lines at eight different time points was performed. Data was analyzed using unsupervised hierarchical clustering, integrated longitudinal expression analysis, and pathway enrichment analysis. Biological relevance of identified key regulatory genes was evaluated in vitro and dual-luciferase assays were used to confirm predicted miRNA-mRNA interactions. We show that the acquisition of anchorage independence of HPV-containing keratinocyte cell lines is particularly associated with copy number alterations. Approximately one third of differentially expressed mRNAs and miRNAs was directly attributable to copy number alterations. Focal adhesion, TGF-beta signaling, and mTOR signaling pathways were enriched among these genes. PITX2 was identified as key regulator of TGF-beta signaling and inhibited cell growth in vitro, most likely by inducing cell cycle arrest and apoptosis. Predicted miRNA-mRNA interactions miR-221-3p_BRWD3, miR-221-3p_FOS, and miR-138-5p_PLXNB2 were confirmed in vitro. Integrated longitudinal analysis of our HPV-induced carcinogenesis model pinpointed relevant interconnected molecular changes and crucial signaling pathways in HPV-mediated transformation.
Demand for family planning satisfied with modern methods and its associated factors among married women of reproductive age in rural Jordan: A cross-sectional study

Background A novel indicator, ‘percentage of women of reproductive age who are sexually active and who have their demands for FP satisfied with modern contraceptive methods (mDFPS)’, was developed in 2012 to accelerate the reduction of unmet needs of family planning (FP). In Jordan, unmet needs for modern contraception remain high. To address this situation, this study measured the mDFPS and identified its associated factors in rural Jordan. Methods This cross-sectional study included married women of reproductive age (15–49 years) from ten villages in Irbid Governorate, Jordan, where advanced health facilities are difficult to reach. A two-stage stratified sampling with random sampling at the household stage was used for this field survey which was conducted between September and October 2016. Univariate analysis was used to assess the differences between mDFPS and unmet mDFPS groups. Logistic regression analysis was performed to identify the correlates of mDFPS. Results Of 1019 participants, 762 were identified as needing modern contraception. mDFPS coverage accounted for 54.7%. The most significant factors associated with mDFPS were the husband’s agreement on FP (adjusted odds ratio [AOR]: 15.43, 95% confidence interval [CI]: 5.26–45.25), knowledge of modern contraceptives (AOR: 8.76, 95% CI: 5.72–13.40), and lack of awareness of the high risk of conception in the postpartum period (AOR: 2.21, 95% CI: 1.41–3.47). Duration of current residence, receipt of FP counselling at health centres and number of living children were also correlated. In addition, 95.3% of local women were aware of the presence of health centres that were mostly located in a 10-minute walking distance. Conclusion To increase mDFPS, this study suggested that accelerating male involvement in FP decision-making is necessary through community-based health education. Furthermore, expanding FP services in village health centres and improving the quality of FP counselling in public health facilities are required to correct misconceptions about modern methods among rural women.
Neurostimulation du cortex préfrontal dorsolatéral : quels effets sur la symptomatologie, l’humeur et les émotions dans la dépression et la schizophrénie ?

La stimulation magnetique transcrânienne repetee (rTMS) et la stimulation transcrânienne par courant continu (tDCS) sont des techniques de stimulation cerebrale non invasive actuellement utilisees comme solutions therapeutiques dans plusieurs pathologies psychiatriques. Appliquees au niveau du cortex prefrontal dorsolateral (CPFDL), elles ont montre leur efficacite pour diminuer les symptomes pharmacoresistants chez les patients deprimes et chez les patients schizophrenes avec symptomes negatifs predominants (SN). Le CPFDL est une structure cerebrale impliquee dans l’expression de ces symptomes et dans d’autres processus dysfonctionnels de ces deux pathologies comme les processus emotionnels. Le but de cette revue est d’etablir s’il existe ou non un lien entre l’amelioration clinique et la modulation des processus emotionnels suite a la stimulation du CPFDL dans ces deux pathologies. Les donnees collectees montrent que l’amelioration des processus emotionnels n’est pas en lien avec l’amelioration clinique ni chez les patients deprimes ni chez les patients SN. Notre revue suggere que bien que partageant des structures cerebrales communes, les reseaux cerebraux impliques dans les processus emotionnels d’une part et les symptomes depressifs ou les SN d’autre part seraient distincts.
Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells

Osteosarcoma (OSA) is the most common malignant bone tumor in children and adolescents. The overall five-year survival rate for all bone cancers is below 70%; however, when the cancer has spread beyond the bone, it is about 15–30%. Herein, we evaluated the effects of carbon-ion beam irradiation alone or in combination with zoledronic acid (ZOL) on OSA cells. Carbon-ion beam irradiation in combination with ZOL significantly inhibited OSA cell proliferation by arresting cell cycle progression and initiating KHOS and U2OS cell apoptosis, compared to treatments with carbon-ion beam irradiation, X-ray irradiation, and ZOL alone. Moreover, we observed that this combination greatly inhibited OSA cell motility and invasion, accompanied by the suppression of the Pi3K/Akt and MAPK signaling pathways, which are related to cell proliferation and survival, compared to individual treatments with carbon-ion beam or X-ray irradiation, or ZOL. Furthermore, ZOL treatment upregulated microRNA (miR)-29b expression; the combination with a miR-29b mimic further decreased OSA cell viability via activation of the caspase 3 pathway. Thus, ZOL-mediated enhancement of carbon-ion beam radiosensitivity may occur via miR-29b upregulation; co-treatment with the miR-29b mimic further decreased OSA cell survival. These findings suggest that the carbon-ion beam irradiation in combination with ZOL has high potential to increase OSA cell death.
Assessment ofthe floristic composition ofwoody tree species inKwari-Kwasa forest reserve, Kebbi State, Nigeria

Nigeria’s forest reserves are in the phase of permanent flux at varying scale by force such as overgrazing, fuelwood extraction and expanding farmlands for agriculture etc. Information on tree species abundance in the forest reserve is required for not only effective but also efficient management. This study aimed to assesses the floristic composition of woody tree species in the Kwari-Kwasa forest reserve of Kebbi state, Nigeria; in order, for sustainable forest management and livelihood options in the area, employ the use of Point Centre Quarter (PCQ) method, a plots of 30m x 30m and it was replicated three times. Eighteen (18) woody tree species were identified in the reserve, While species Combretumnigricans and Guierasenegalensis dominates the reserve, accounting for thearea (0.7956m 2 ) representing 50.1% and (0.0426m 2 ) representing 40.3% of the woody trees species in the reserve respectively. Species Crossopteryxspp and Vitellariaparadoxum are less dominance with 0.1% each. Species diversity index of 1.5-2.9 and species richness of 2.210 was documented in the reserve with evenness values ranges from 1.27 to 2.31. There was severe and excessive overexploitation of woody tree species in the reserve. This is evident that rapid Forest degradation ensues mainly due to fuelwood extraction, land conversion for farming and multiple anthropogenic factors. A sound regeneration effort involving enrichment planting, education of local populace, strong law enforcement and forest guards are necessary so as to limit the further tree destruction and sustainable management of the reserve.
Time capsule: Nostalgia shields psychological wellbeing from limited time horizons.

Nostalgia is a bittersweet-albeit predominantly positive-self-relevant and social emotion that arises from reflecting on fond and meaningful autobiographical memories. Nostalgia might facilitate successful aging by serving as a socioemotional selectivity strategy in the face of limited time horizons. Four studies tested the role of nostalgia in maintaining psychological wellbeing across the adult life span and across differing time perspectives. In Study 1, community adults (N = 443, age 18-91) completed measures of nostalgia proneness and 6 psychological wellbeing dimensions. Age was more positively related to wellbeing for those high than low on nostalgia proneness: High-nostalgic individuals showed a maintenance or increase in psychological wellbeing with age, whereas low-nostalgic individuals did not. In Study 2 (N = 35, age 18-25), experimentally inducing a limited time perspective-a core trigger of socioemotional selectivity-in young adults prompted greater nostalgia. In Study 3 (N = 93, age 18-33) and Study 4 (N = 376, age 18-55), experimentally inducing a limited time perspective reduced some aspects of wellbeing among those who recalled an ordinary (Study 3) or lucky (Study 4) autobiographical memory, but this effect was eliminated among those who recalled a nostalgic memory. Nostalgia buffers perceptions of limited time and facilitates the maintenance of psychological wellbeing across the adult life span. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
Real world study for the concordance between IBM Watson for Oncology and clinical practice in advanced non‐small cell lung cancer patients at a lung cancer center in China

IBM Watson for Oncology (WFO) provides physicians with evidence‐based treatment options. This study was designed to explore the concordance of the suggested therapeutic regimen for advanced non‐small cell lung (NSCLC) cancer patients between the updated version of WFO and physicians in our department, in order to reflect the differences of cancer treatment between China and the United States.
Benthic Crustacean Digestion Can Modulate the Environmental Fate of Microplastics in the Deep Sea

Microplastics (MPs) are ubiquitous contaminants of the marine environment, and the deep seafloor is their ultimate sink compartment. Manipulative and field experiments provided evidence of the ingestion of MPs by deep-sea fauna, but knowledge of MPs’ fate once ingested still remains scant. We provide evidence of MP partial retention and fragmentation mediated by digestion activity of a Norwegian langoustine, a good bioindicator for MP contamination of the deep sea. We report here that MPs in the intestines were more abundant and significantly smaller (up to 1 order of magnitude in surface) than those in the stomachs. Our results show that the stomach can act as a size-bottleneck for ingested MPs, enhancing the retention of larger particles within the stomach and promoting fragmentation into smaller plastic debris, which is then released in the intestine. Our results provide evidence that the langoustine is responsible for the fragmentation of MPs already accumulated in sediments through its scavenging activity and digestion. These findings highlight the existence of a new peculiar kind of “secondary” MPs, introduced in the environment by biological activities, which could represent a significant pathway of plastic degradation in a secluded and stable environment such as the deep sea.