Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis

Background The role of RAD51 gene polymorphisms with the development of head and neck cancer (HNC) and esophageal cancer (EC) remains controversial. This meta-analysis was conducted to evaluate the correlation between the RAD51 polymorphisms and these two cancers quantitatively. Methods Databases of PubMed, Web of Science, and Embase were used to search relevant papers prior to August 17, 2019. STATA 11.0 was performed to observe the correlation. Results Ten relevant papers were enrolled in our analysis. Overall, a significant correlation was observed between the rs1801320 polymorphism and the increased risk of these two cancers (OR = 1.32, 95%CI = 1.03‐1.71 for C vs. G; OR = 1.50, 95%CI = 1.03‐2.19 for CG vs. GG; and OR = 1.44, 95%CI = 1.05‐1.99 for CC+CG vs. GG). In subgroup analyses, an increased risk was found for EC (OR = 2.07, 95%CI = 1.01‐4.25 for C vs. G; OR = 2.08, 95%CI = 1.17‐3.71 for CC vs. GG; and OR = 1.78, 95%CI = 1.00‐3.15 for CC vs. CG+GG), but not for HNC. Moreover, our analysis revealed that no statistical evidence of correlation was discovered between the polymorphism of rs1801321 and the increased risk of HNC. However, stratified analysis based on ethnicity suggested that rs1801321 polymorphism was related to the decreased risk of HNC among Caucasians (OR = 0.82, 95%CI = 0.72‐0.95 for T vs. G). Conclusions rs1801320 polymorphism was strongly associated with the risk of these two associated cancers, especially with esophageal cancer. Moreover, our results revealed that rs1801321 polymorphism was correlated to the decreased risk of HNC among Caucasians.
EVALUATION OF HISTORICAL HERITAGE DOCUMENTATION: REALITY BASED SURVEY AND DERIVATIVE MODELS

Abstract. Three-dimensional acquisition systems for architecture have significantly evolved over just a few decades, with them allowing point clouds to be generated through active and passive optical sensor equipment. Accuracy levels vary considerably in relation to both the equipment and techniques used, with the data obtained acting as a scaffolding for the creation of derived models that allow specific analyses to be carried out. Ongoing research on Palazzo Donn’Anna, a Neapolitan sixteenth-century building of particular historical and artistic value, is being carried out in this context and the first results are presented in this paper. The entire building has been the subject of an instrumental survey. The north-east facade was proposed as a case-study for the experimentation of diversified reality-based sensors so as to compare the accuracy and precision of the data. The comparison was also aimed at evaluating the performance of some processing softwares. Finally, in order to obtain an estimate of the data in the transcription from the point cloud to a derived 3D model, the reproduction of the same portion of the prospectus in a derivative model of both object-oriented and NURBS types was experimented.
Huge Arteriovenous Malformation of Upper Lip- A Case Report

Introduction: Arteriovenous malformations (AVMs) are uncommon vascular lesions that can arise in any part of the body. Case Report: In this case study, we presented a huge AVM of the upper lip in a 70-year-old man that he noticed since 5years ago with slow growth in this period. Computed tomography angiography revealed a large AVM with feeders from the right facial artery and its branch superior labial artery. Right facial artery showed increased diameter and tortuous changes. Selective catheterization of right carotid was performed followed by super selective catheterization of the right facial artery. Then, the embolization of the tumor blush was conducted. Surgical removal of the tumor was carried out10days after the embolization. Conclusion: The AVM treatment is challenging, and there is a high chance of recurrence and progression. Every case should have an individualized approach that needs an accurate diagnosis and a multidisciplinary team.
Assessment of Health Related to Quality of Life in Hypertensive and Diabetic Mellitus patients in Kurdistan/Iraq

Background: Hypertension and diabetes mellitus are chronic diseases, therefore; they had negative effect on quality of life of affected patients. Aim: The aim of this study was to assess health related to quality of life of hypertensive and diabetes mellitus patients through measuring their socioeconomic status, medical conditioning and co-morbidity. Methodology: This is cross sectional study that has been carried out in Kurdistan- Iraq. Health Survey Questionnaire, Short form-12 was used for measuring health related quality of life. Conventional sampling method was carried out for collecting of data. T-Test was used to analyze the data Result: Mean Health Survey Questionnaire, Short Form-12 score was 39.0±1.64, mean of physical component summary was 36.6±1.9 and mean of mental component summary of was 41.5±1.6. Health related quality of life among hypertensive and diabetes mellitus patients were poor in Kurdistan. On the other hand, poor health related quality of life was less observed in hypertension patients 39.7±1.7 as compared with diabetic patients 41.9±1.6. Participants who were female, elder, did not have spouse and did not have job and/or retired were significantly and negatively associated with poor health related quality of life. Conclusions: Health related quality of life among hypertensive and diabetes mellitus patients were poor in Kurdistan as compared with other countries. Included participants, who were female, elder, did not have spouse, did not have job and/or retired were significantly had poor health related quality of life. Recommendation: Further recommends study longitudinal for assessing components of health related quality of life in both diseases separately(hypertension and diabetes).
Sevoflurane and its metabolism

Sevoflurane is one of the inhaled anesthetics which has been broadly applied in clinic.But it is not as stable as isoflurane,desflurane in physical and chemical properties because biotransformation will happen in about 5% of them.And of its metabolites,hexafluoroisopropanol has a very strong anesthetic potency.The article elaborates the nature and metabolism of sevoflurane by summarizing research progresses in recent years in order to better guide the clinical application of Sevoflurane.
Testing the linkages of Arab stock markets: a multivariate GARCH approach

The authors undertook to examine 720 monthly observations of activity in 15 Arab stock markets over four years (from 2014 to 2017) to identify the dynamic linkages among those markets. To achieve this, several forms of the Generalized Auto-Regressive Conditional Heteroskedasticity (GARCH) model were utilized. Both panel and individual stationarity, in addition to cointegration tests, were employed to highlight the interaction between these markets. The results suggest that Arab stock markets have weak linkages with the exception of those of the Gulf Cooperation Council (GCC). The authors also find out that the TARCH, EGARCH, PARCH, and Component GARCH (1,1) models are suitable in terms of passing the econometric analysis tests. Nevertheless, they conclude that the EGARCH model is the most appropriate for capturing the cross-market dynamic linkages, thereby outperforming the other GARCH specifications under study. The empirical findings bear special implications for economic literature regarding linkages of stock markets in the Arab world.
Comparisons of Effective Fields of Two Ultra-Widefield Ophthalmoscopes, Optos 200Tx and Clarus 500

Purpose To compare the effective fields of the Optos 200Tx® and Clarus 500™, two ultra-widefield ophthalmoscopes, based on their ability to image branches of retinal vessel in the four retinal quadrants. Methods Ninety retinal images from 90 patients with various eye diseases were studied. All patients had undergone 200° retinal imaging to obtain a single image of Optos (O) and the montage of two images of the Clarus (C). The highest number of traceable vessel branches in the four retinal quadrants was determined by two masked raters. An image was classified as “O > C” when the number of identifiable branch was greater in the Optos than the Clarus, as “O = C” when the number was equal and as “O < C” when the number was fewer in the Optos than the Clarus. Results The appearance probability of “O > C” was significantly higher at the upper temporal quadrant than “O < C” (p < 0.01 for both raters). In contrast, the appearance probability of “O < C” was significantly higher at the lower nasal quadrant than “O > C” (p < 0.01 for both raters). There were no significant differences in the appearance probability between “O > C” and “O < C” at the other two retinal quadrants (p > 0.50 for both raters). Conclusions These results demonstrate that the effective field of views was different between the two devices at different retina quadrants. Further studies are needed to clarify possible factors such as artifacts by the eyelashes, differences in the depth of focus, motion of the device, and different locations of the images on the effective field of views.
Characterizing task-specific motor variability in human skilled movements as dynamical invariants: a case study

Human body is at the center of our day-to-day activities. To reveal bodily skills hidden in our daily life, we need to understand how our central nervous system manipulates our body. Ones hypothesized that the motor variability of our skilled movements is constrained to task-irrelevant subspace. This hypothesis predicts that human skilled movements show small variability in trajectory, where the variability is critical in task performance. We attempted to test this prediction by characterizing human bodily movements regarded as those generated by a dynamical system. The results of our analysis matched this prediction: the motor variability in trajectory, or the degrees-of-freedom, reduces near the ‘critical point’ of motion regarding the task.
Prevalence of Bacterial Lower Respiratory Tract Infections at a Tertiary Hospital in Jordan

Background: Lower respiratory tract infections (LRTIs) are a major cause of morbidity and mortality globally. The World Health Organization (WHO) estimates that LRTIs are the most common global cause of death from infectious diseases. However, the specific etiologic agent associated with LRTI is often unknown. We determined the bacterial infections and seasonal patterns associated with LRTIs among hospitalized cases at Jordan University Hospital (JUH) for a period of five years. Methods: We conducted a retrospective multi-year study among hospitalized patients in Jordan on LRTI-associated bacterial etiology. Results: We found bacterial infections among 105 (21.1%) out of 495 LRTI patients. The most frequently identified bacteria in the LRTI patients were Staphylococcus aureus (7.7%) followed by Pseudomonas aeruginosa (5.1%). Most of the LRTI patients (95.2%) had at least one chronic disease and many were admitted to the Intensive Care Unit (16.8%). Of the 18(3.64%) patients with LRTIs who died at the hospital, 2 had a bacterial infection. We noticed a seasonal pattern of bacterial infections, with the highest prevalence during the winter months. Conclusions: Our findings suggest that early identification of bacterial agents and control of chronic disease may improve clinical management and reduce morbidity and mortality from LRTIs. Prevalence of Bacterial Lower Respiratory Tract Infections at a Tertiary Hospital in Jordan Nathir Obeidat1, Isam Bsisu2, Faruque Parvez3, Zafrin Islam4, Zaina Obeidat5,Mai Altous6, Mohammed N. Obeidat7, Nidaa Ababneh8, Ayman Wahbeh5, Randa Farah5 1 Pulmonary Medicine and Critical Care Division, Department of Internal Medicine, Jordan University Hospital, Amman, Jordan. 2 Department of Anesthesia and Intensive Care, School of Medicine, University of Jordan, Amman, Jordan. 3 Mailman School of Public Health, Columbia University, New York, NY USA. 4 Department of Biochemistry, University of Toronto, Toronto, Canada. 5 Internal Medicine Department, School of Medicine, University of Jordan, Amman, Jordan. 6 Interventional Pulmonary and Critical Care Unit, King Hussein Cancer Foundation and Center, Amman, Jordan. 7 School of Medicine, University of Jordan, Amman, Jordan. 8 Cell Therapy Center, University of Jordan, Amman, Jordan. Contact information:
1 Theory for Quench Dynamics in a Harper Ladder 1 . 1 Bloch Bands and Wannier Functions of the Harper Ladder

In this section we consider the non-interacting limit where U = 0. Despite the presence of the magnetic flux Φ per plaquette, a gauge choice can be made for the ladder geometry with a two-site unit cell corresponding to an individual rung. Now we derive the cell-periodic Bloch wavefunctions |u±(q)〉 of the resulting two bands. After deriving their dispersion relations ±(q), we discuss particle-hole symmetry and calculate the corresponding Wannier functions w±(x, y).
Degradation and Operation-Aware Framework for the Optimal Siting, Sizing, and Technology Selection of Battery Storage

This paper addresses the problem of optimal siting, sizing, and technology selection of Energy Storage System (ESS) considering degradation arising from state of charge and Depth of Discharge (DoD). The capacity lost irreversibly due to degradation provides the optimizer with a more accurate and realistic view of the capacity available throughout the asset's entire lifetime as it depends on the actual operating profiles and particular degradation mechanisms. When taking into account the ESS's degradation, the optimization problem becomes nonconvex, therefore no standard solver can guarantee the globally optimal solution. To overcome this, the optimization problem has been reformulated to a Mixed Integer Convex Programming (MICP) problem by substituting continuous variables that cause nonconvexity with discrete ones. The resulting MICP problem has been solved using the Branch-and-Bound algorithm along with convex programming, which performs an efficient search and guarantees the globally optimal solution. We found that the optimal battery use does not necessarily correspond to it reaching its End of Life state at the end of the service lifetime, which is the result of nonlinear degradation mechanicms from both idling and cycling. Finally, the proposed methodology allows formulating computationally tractable stochastic optimization problem to account for future network scenarios.
Overexpression of eIF3D in Lung Adenocarcinoma Is a New Independent Prognostic Marker of Poor Survival

The eukaryotic initiation factor 3 (eIF3) is the largest and most complex translation initiation factor in mammalian cells. It consists of 13 subunits and among which several were implicated to have significant prognostic effects on multiple human cancer entities. To examine the expression profiles of eIF3 subunits and determine their prognostic value in patients with lung adenocarcinoma (LUAD), the genomic data, survival data, and related clinical information were obtained from The Cancer Genome Atlas (TCGA) project for a secondary analysis. The results showed that among ten aberrantly expressed eIF3 subunits in tumours compared with adjacent normal counterparts (p < 0.05), only upregulated eIF3D could predict poor overall survival (OS) outcome independent of multiple clinicopathological parameters (HR = 2.043, 95% CI: 1.132-3.689, p = 0.018). Chi-square analysis revealed that the highly expressed eIF3D group had larger ratios of patients with advanced pathological stage (68/40 vs. 184/206, p = 0.0046), residual tumour (13/4 vs. 163/176, p = 0.0257), and targeted molecular therapy (85/65 vs. 138/164, p = 0.0357). In silico analysis demonstrated that the altered expression of eIF3D was at least regulated by both copy number alterations (CNAs) and the hypomethylation of cg14297023 site. In conclusion, high eIF3D expression might serve as a valuable independent prognostic indicator of shorter OS in patients with LUAD.
GENERATING RANKING FOR CLOUD SERVICES USING CLOUD RANK FRAMEWORK

QoS (Quality-of-Service) and Building high quality cloud applications becomes an urgently required is an important topic in cloud computing. it is very difficult to choose which service is best one to use and what the criteria for their selection are. Quality of service parameters can be used to select the best possible service provider. The providers can be ranked according to the Quality of services. Two QoS ranking prediction algorithms are used to predict the QoS rankings. In the proposed work the feedback method is used to predict the ranking based on the likes given by the end users. In order to avoid this scenario we propose an approach which directly predicts the QoS ranking by taking past QoS data of other consumers without checking for the subsequent QoS values of other web services.
A Simplified Inverse Dynamics Modelling Method for a Novel Rehabilitation Exoskeleton with Parallel Joints and Its Application to Trajectory Tracking

In this paper, a new modular upper limb rehabilitation exoskeleton, which is actuated by a parallel mechanical structure, is designed to help stroke patients. For analysing the relationship between motor torque and joint torque of the novel exoskeleton, a conversion algorithm mapping motor motion to joint motion is developed here. Then, to simplify the dynamics model of exoskeleton with parallel actuated joints, the serial equivalence configuration dynamics of the exoskeleton is established to be equivalent to the parallel joints dynamics. Afterwards, a torque controller used for our exoskeleton is designed based on the proposed conversion algorithm and the inverse dynamics of exoskeleton. It should be noted that the controller mentioned above combines both conversion algorithm and joint position decoupling. At last, for verifying the effectiveness of the proposed algorithms, a trajectory tracking simulation is given, and the simulated results show the proposed algorithms are valid.
Transcription factor Sp 3 is silenced through SUMO modi ® cation by PIAS 1

Sp3 is a ubiquitous transcription factor closely related to Sp1. Here we show that Sp3 is a target for SUMO modi®cation in vivo and in vitro. SUMO modi®cation of Sp3 occurs at a single lysine located between the second glutamine-rich activation domain and the DNA-binding domain. Mutational analyses identi®ed the sequence IKXE as essential for SUMO conjugation to Sp3. We identi®ed the protein inhibitor of activated STAT1 (PIAS1) as an interaction partner of Sp3 and Ubc9. Moreover, PIAS1 strongly stimulated SUMO conjugation to Sp3, thus acting as an E3 ligase for SUMO conjugation to Sp3. All mutations that prevented SUMO modi®cation in vitro strongly enhanced the transcriptional activity of Sp3, showing that SUMO modi®cation silences Sp3 activity. SUMOmodi®ed Sp3 bound to DNA with similar speci®city and af®nity as unmodi®ed Sp3. However, DNA-bound Sp3 did not act as a substrate for SUMO modi®cation.
"Making Space": Lessons from Collaborations with Tribal Nations

In light of critiques regarding the concept of service, and after highlighting limits of critical servicelearning and “authentic” relationship approaches, this article presents “making space” for marginalized community perspectives as an alternative metaphor for conceptualizing university-community relationships. Drawing upon multiple experiences with American Indian tribal nations, the article identifies deeply intercultural, counterhegemonic, and decolonizing dynamics enacted through making space, and which produce a discomforting reversal of the common analytic focus on community service recipients. Making space also enables university-community alignment, the generation of projects truly based in community interests, and facilitates interactions outside and disruptive of hegemonic power/knowledge regimes and discourses. The field of service-learning, increasingly supported as a common element of higher education, faces a range of questions about its nature, practice, and theory. Central among these is the very notion of service itself, the types of experience it entails, and students’ relationship to those being served. While service-learning takes some inspiration from Deweyian educational theory that emphasizes problematic and disruptive situations as the origin of inquiry (Dewey, 1916; Garrison 1996, p. 16), and originated in first-generation learning experiences that were frequently only semi-structured and “messy” (Stanton, Giles, & Cruz 1999), much current service-learning appears to be highly structured and orderly. As service-learning increasingly refers to volunteer experiences touted as community service by colleges and universities, the nature of service, and the action and relationships involved in service, are worthy of ongoing debate and discussion. This article does not attempt to craft a new definition of service, however, or parse the multitude of definitions that have been introduced and reviewed elsewhere. Rather, through this article I aim to contribute to the theorization of “service” by problematizing common understandings of service and action while promoting the notion of “making space” as one alternative (Regan, 2010). Making space, a concept drawn from reconciliation efforts involving the Canadian government and First Nations (Regan), is consistent with and extends the growing emphasis within the existing service-learning literature on both “critical” service-learning and sustained community-university relationships. My discussion of the making space metaphor and its potential are based in my participant-observation in communitybased collaborations with Indigenous Nations, interviews with university and tribal participants in such
Analysis of the position and strength of westerlies and trades with implications for Agulhas leakage and South Benguela upwelling

Abstract. The westerlies and trade winds over the South Atlantic and Indian Ocean are important drivers of the regional oceanography around southern Africa, including features such as the Agulhas Current, the Agulhas leakage, and the Benguela upwelling. Agulhas leakage constitutes a fraction of warm and saline water transport from the Indian Ocean into the South Atlantic. The leakage is stronger during intensified westerlies. Here, we analyze the wind stress of different observational and modeled atmospheric data sets (covering the last 2 millennia, the recent decades, and the 21st century) with regard to the intensity and position of the southeasterly trades and the westerlies. The analysis reveals that variations of both wind systems go hand in hand and that a poleward shift of the westerlies and trades and an intensification of westerlies took place during the recent decades. Furthermore, upwelling in South Benguela is slightly intensified when trades are shifted poleward. Projections for strength and position of the westerlies in the 21st century depend on assumed CO2 emissions and on their effect relative to the ozone forcing. In the strongest emission scenario (RCP8.5) the simulations show a further southward displacement, whereas in the weakest emission scenario (RCP2.6) a northward shift is modeled, possibly due to the effect of ozone recovery dominating the effect of anthropogenic greenhouse forcing. We conclude that the Agulhas leakage has intensified during the last decades and is projected to increase if greenhouse gas emissions are not reduced. This will have a small impact on Benguela upwelling strength and may also have consequences for water mass characteristics in the upwelling region. An increased contribution of Agulhas water to the upwelling water masses will import more preformed nutrients and oxygen into the upwelling region.