Miracle-dz/UniFAR-FTUs huggingface dataset:
An Analog-Proportional Digital-Integral Multiloop Digital LDO With PSR Improvement and LCO Reduction

This article presents a low-dropout regulator (LDO), with analog-proportional (AP) and digital integral (DI) controls. The design concerns are discussed at first, on how to improve the load transient response, enhance the power supply rejection (PSR), and reduce the limit cycle oscillation (LCO). For a good output dc accuracy, the DI section is implemented with shift-register-based coarse- and fine-tuning loops. Meanwhile, the AP section, based on a low-supply flipped-voltage follower (FVF), can respond fast to the load step and input supply ripple. A replica loop is used to define the steady-state output current of AP, allowing a sufficient dynamic swing against the supply ripple. To lower the load current range with no LCO, the AP section will output all the current at very light load. An error amplifier (EA) with moderate gain is added to improve the light-load output accuracy. This EA also improves the PSR by approximately 6 dB. Fabricated in a 65-nm CMOS process, a 65-mV undershoot is measured with a 0–10-mA load current step under 0.6-V supply voltage and 50-mV dropout. Due to the fast AP, a 5-MHz operation clock is applied to the digital section, reducing the overall quiescent current to 29 $\mu \text{A}$ . A 0.37-ps figure of merit (FoM) is then achieved. A −22-dB PSR at 1 MHz is measured at 0.6-V supply, 100-mV dropout, and 10-mA load current.
Evaluation of the Fermentation Dynamics of Commercial Baker’s Yeast in Presence of Pistachio Powder to Produce Lysine-Enriched Breads

The present work was carried out to evaluate the microbiological, physicochemical, and sensory characteristics of fortified pistachio breads. Pistachio powder (5% w/w) was added to flour or semolina and fermented by a commercial baker’s yeast (Saccharomyces cerevisiae). Pistachio powder did not influence the biological leavening of the doughs. The kinetics of pH and total titratable acidity (TTA) during dough fermentation showed that the leavening process occurred similarly for all trials. The concentration of yeasts increased during fermentation and reached levels of 108 CFU/g after 2 h. Pistachio powder decreased the height and softness of the final breads and increased cell density of the central slices. The amount of lysine after baking increased in pistachio breads and this effect was stronger for semolina rather than flour trials. Sensory evaluation indicated that fortified breads processed from semolina were those more appreciated by the judges. This work clearly indicated that the addition of pistachio powder in bread production represents a promising strategy to increase the availability of lysine in cereal-based fermented products.
FACTORS INFLUENCING HEALTH BEHAVIOR AMONG TYPE 2 DIABETES MELLITUS PATIENTS: AN INTEGRATIVE REVIEW

Objective: This integrative review aims to summarize and identify the current literature related to health behavior among Type 2 Diabetes Mellitus (T2DM) Patients and its factors. Methods : An integrative review was undertaken using literature published between 2000 and 2013, based on CINAHL, Springer link, PubMed, Science Direct and Google Scholar. Results : Twenty-two articles were selected based on inclusion and exclusion criteria. This review indicated a wide range of factors influencing health behavior among T2DM patients including predisposing factors (socioeconomic, knowledge, stress management, and health belief), reinforcing factor (family support), and enabling factor (health service). Conclusion : Family support, socioeconomic and knowledge are the significant major factors of health behavior among T2DM patients. However, the others factors such as stress management, health belief and health service are also the important factors for T2DM patient’s health behaviors. Therefore, these factors should be considered for development of appropriate interventions to promote health behavior among T2DM patients at community.
Defining the Final PPNB/PPNC in the Southern Levant: insights from the chipped stone industries of Beisamoun

This work has been made possible thanks tot the support of the french Ministry of Foreign Affairs (MAEDI), the French National Centre for Scientific Research (CNRS), the Israel Antiquities Autority (IAA), the Irene Levi-Sala Care Archaeological Foundation, the Centre de Recherche Francais a Jerusalem (CRFJ) and the Generalitat de Catalunya ('Archaeology of Dinamics' group, ref. 2017-SGR-995). The chapter was written while Ferran Borrell held a Ramon y Cajal contract (RYC-2016-21108) at the Institucio Mila i Fontanals (IMF-CSIC).
Magnetic resonance imaging biomarkers of cancer : with applications in high intensity focused ultrasound treatment evaluation

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication
The Makings of a Tumor Rejection Antigen Review

strong tumor rejection antigens, describing quantita-Center for Genetic and Cellular Therapies tively the impact of the immune response on tumorDepartment of Surgery growth. The extent to which an antigen is a tumor rejec-Duke University Medical Center tionantigen isalso afunction ofthe immunizationproto-Durham, North Carolina 27710 col. A weak tumor rejection antigen can record as astrongtumorrejectionantigenbyusinganeffectivevac-cinationprotocol,suchasprotocolsthatfavortheinduc-The demonstration that naturally induced tumors in ro- tion of CTL responses and the Th-1 subset of CD4
Enhanced laser–plasma interactions using non-imaging optical concentrator targets

Picosecond-scale laser–matter interactions using compound parabolic concentrators have demonstrated strongly relativistic ponderomotive effects with $\sim{10} \times $∼10× increase in x-ray source brightness, positron production and multi-MeV proton acceleration versus flat targets, using a marginally relativistic intensity laser.
Projeto de classificadores para sistema de reconhecimento automático de modulações

A subutilizacao do espectro de frequencia e uma problema recorrente atualmente e, com o aumento da demanda de usuarios que utilizam sistemas de comunicacao remota, foi necessario buscar uma maneira mais eficiente de alocar usuarios no espectro, surgindo assim, as tecnicas que aplicam o radio cognitivo. O radio cognitivo, detecta buracos espectrais e aloca de maneira dinâmica usuarios nestes espacos inutilizados. Com isso em vista, as tecnicas de classificacao automatica de modulacao vieram para fornecer informacoes a priori que auxiliam no sensoriamento do espectro. Nesta dissertacao propoe-se, para classificar sinais modulados, utilizar uma gama de classificadores multiclasse supervisionados baseados em aprendizado de maquina e aprendizado profundo, com seus parâmetros pre-estabelecidos. Dentre os classificadores englobados em aprendizado de maquina, abordamos algoritmos baseados em arvore de decisao e algoritmo de classificacao probabilistica, Naive Bayes. Dentro do aprendizado profundo, aplicou-se redes neurais artificiais atraves de uma rede perceptron multicamada totalmente conectada com retropropagacao utilizando algoritmo de Levenberg-Marquardt para atualizacao dos pesos da rede. Foram obtidos taxas de acuracia de 95,2866% e 93,1253% nos classificadores baseados em arvore de decisao, 87,4% na rede neural e 74,7845% no Naive Bayes. Na literatura foi encontrado um trabalho com base de dados semelhante qualitativamente a utilizada nesta dissertacao e sua acuracia foi de 89,72%, enquanto a melhor acuracia apresentada nesta dissertacao foi de 95,2866%.
Modeling of Root Nitrate Responses Suggests Preferential Foraging Arises From the Integration of Demand, Supply and Local Presence Signals

A plants’ fitness to a large extent depends on its capacity to adapt to spatio-temporally varying environmental conditions. One such environmental condition to which plants display extensive phenotypic plasticity is soil nitrate levels and patterns. In response to heterogeneous nitrate distribution, plants show a preferential foraging response, enhancing root growth in high nitrate patches and repressing root growth in low nitrate locations beyond a level that can be explained from local nitrate sensing. Although various molecular players involved in this preferential foraging behavior have been identified, how these together shape root system adaptation has remained unresolved. Here we use a simple modeling approach in which we incrementally incorporate the various known molecular pathways to investigate the combination of regulatory mechanisms that underly preferential root nitrate foraging. Our model suggests that instead of a thus far not discovered growth suppressing supply signal, growth reduction on the low nitrate side may simply arise from a reduced root foraging and increased competition for carbon. Additionally, our work suggests that the long distance CK signaling involved in root growth increase in high nitrate patches may represent a supply signal specifically functioning in modulating demand signaling strength. We illustrate how this integration of demand and supply signals prevents excessive preferential foraging under conditions in which demand is not met by sufficient supply and a more generic foraging in search of nitrate should be maintained.
Construction of a novel bat coronavirus glycoprotein pseudotyped lentiviral vector and analysis of cell tropism

Since the SARS epidemic in 2003, and the subsequent identification of bats as the reservoir host, there has been a surge of interest in research into bat-borne viruses, with over 30 new bat coronaviruses alone being discovered. Investigating the cell tropism of these newly discovered coronaviruses deepens the understanding of their pathology and possible host ranges, as well as allowing assessments to be made on their zoonotic potential. Aside from biosafety concerns however, this is also reliant on isolation of the virus from its host, which can be difficult using conventional methods. This project aimed to develop a second generation lentivirus pseudotyping system which would allow spike proteins, the main determinants of coronavirus cell entry, of a non-isolated coronavirus to be safely expressed on a lentiviral particle in order to assess its cell tropism. The system was developed and tested using the spike gene from CoV1087, a novel bat-borne coronavirus with a 70% similarity at both the coding RNA and amino acid level between its spike protein and that of porcine epidemic diarrhea virus strain CH-HNYF-14. Overall this study resulted in the successful development of a lentiviral pseudotyping system which allows the efficient analysis of the cellular tropism of coronaviruses. Through the testing and development of this system, it was determined that CoV1087 could enter two human cell lines, 293T and CaCo-2 as well as one rabbit cell line, RK-13. This raises the possibility of the transfer of the virus to feral rabbits as well as the possibility of zoonotic human infections.
Selective attention modulates temporal processing

A near continuous stream of information reaches our eyes and the task of the visual system is to make sense of it. Visual stimuli arrive in quick succession: sometimes it is necessary to integrate stimuli over time, but other times it is necessary to segregate them. These opposing processes of integration and segregation are two forms of temporal processing, a topic which is underrepresented in the literature as compared to spatial processing. In particular, there is limited understanding about how temporal processing is influenced by selective attention. Selective attention refers to a family of mechanisms by which the limited resources of our mental architecture are diverted to preferentially process stimuli more likely to be relevant. Here, a number of empirical investigations into the effect of endogenous, covert spatial attention on temporal processing are presented. This includes use of a task in which visual stimulation is held constant and only the temporal processing goal (integration versus segregation) and the spatial location of attention are manipulated. There were strong spatial cueing effects: a benefit to performance when validly cued and a cost when invalidly cued. These attentional effects are reliable for both opposing processes of temporal integration and segregation. Furthermore, these spatial cueing effects are robust even when the cues provide no implicit temporal expectations. We used magnetoencephalography and the same task to measure changes in the brain signal associated with these effects, namely shifts in peak alpha frequency for integration as compared to segregation, as well as spatially specific modulations in this metric relative to the locus of attention. These findings of robust spatial cueing effects on temporal processing and of strategic shifts in oscillatory frequency associated with temporal processing goals and allocation of attention are discussed within a temporal windows framework and in the context of other candidate mechanisms. The empirical evidence reported here can be accounted for by the idea of a flexible adaptation of the size of temporal windows, essentially changing the sampling rate of perception in line with task demands.
Design and evaluation of contracts for gradual typing

Gradual typing aims to improve the correctness of dynamically typed programs by incrementally adding type information. Sound gradual typing performs static type checking and inserts run-time checks when a type cannot be guaranteed statically. This form of gradual typing o ers many features, but also requires that the programmer uses a language with a specialised gradual type system. A lightweight form of gradual typing uses contracts to enforce types at run-time, assigning blame when a type assertion fails. Contracts can be implemented as a library, without requiring a specialised gradual type system. Contracts provide a lower barrier of entry into sound gradual typing. This thesis investigates the design and evaluation of contracts for gradual typing, focusing on bridging the gap between JavaScript (dynamic) and TypeScript (static). There are two key outcomes regarding theory and practice. Contracts for higherorder intersection and union types can be designed in a uniform way, using blame to derive the semantics of contracts satisfaction. Contracts and gradual typing can be evaluated using the De nitelyTyped repository, where JavaScript libraries are annotated with TypeScript de nition les. Contract composition is the fundamental method for building complex type assertions. Intersection and union types are well suited for describing patterns common to dynamically typed programs. Our rst contribution is to present a calculus of contracts for intersection and union types with blame assignment, giving a uniform treatment to both operators. A correct model of contracts must include a de nition of contract satisfaction. Our second contribution is to show that contract satisfaction can be de ned using blame: satisfying programs are those that do not elicit blame when monitored. We de ne a series of properties mandating how contract satisfaction should compose, ensuring that a contract for a type behaves as one would expect for that type. Building on our technical developments, our third contribution is a practical evaluation of gradual typing using the De nitelyTyped repository. We show that contracts can be used to enforce conformance to a de nition le, detecting errors in the speci cation. Our evaluation also reveals that technical concerns associated with implementing contracts using JavaScript proxies are a problem in practice.
Tinjauan Laki-Laki Feminin Perspektif Regulasi Penyiaran Indonesia dan Sosial Budaya Dalam Moderasi Islam

Feminine male behavior is the behavior of a man imitating a person’s feminity. For some people, this behavior is a natural thing in the world of entertainment, but for others it is a matter that violates the normative. It is often performed by the actors who play a role in a television broadcast program, the implications of such behavior in fact inconsistent with the values or religion, culture, and age restictions. However, regulation of such behavior of considered weak because it does not specify the prohibition of such behavior. On the hand, this regulations become something protected, there will be the possibility of some people who give propaganda against male behavior feminine through broadcast media. Result found first, that the feminine male behavior is not accordance with norms of religion, and culture. Second, the absence of regulation significantly explain the behavior of men who resemble women in the Code of Conduct of Broadcast (P3) and the Broadcast Program Standards (SPS) 2012. Third, the link with the socio-cultural behavior is deliberately displayed on the broadcast program to destabilize heterosexual normative view.
Determinants of public sector accounting reforms

The purpose of this paper is to extend the New Public Financial Management concept and the contingency model approach to an analysis of the determinants of the accrual-based International Public Sector Accounting Standards (IPSAS) adoption process as a financial management reform in Sri Lanka, a developing country in Asia. ,Based on the prior literature, this paper develops a framework to highlight the importance of accrual-based reforms in public sector accounting policies to enable better transparency and accountability. It shows the extent to which Sri Lankan public sector institutions have adopted IPSAS-based accounting standards and the limitations of adopting these standards in a developing country, using documentary analysis. ,In developing countries, the public sector faces practical problems when adopting reforms due to limited institutional capacity, high political involvement and bureaucracy in decision making. This paper concludes that significant policy changes towards the adoption of international accounting standards have gained momentum over the last decade in Sri Lanka while the much larger economies in Asia are still studying this process. However, the prevailing political uncertainty in Sri Lanka has negatively impacted the implementation process. ,Relatively little is known about the diffusion of, and the difficulties in, implementing accrual-based IPSAS in the Asian region. This paper is an attempt to fill this gap by exploring the Sri Lankan experience. This could be applied by other developing countries in Asia, including the high-growth nations, for policy adoption and accounting harmonisation.
DELINEATING THE PLACE BRAND FACTORS INFLUENCING SOUTH AFRICA AS AN EMERGING BUSINESS TOURISM DESTINATION

The proliferation of place brands within the global tourism market has resulted in the need for emerging business tourism markets such as South Africa to better understand their potential influence on tourists‟ decision-making. The aim of the study was to delineate the place brand factors influencing business tourism to South Africa and explore the nexus between South Africa‟s place brand and business tourism. Quantitative data was generated from a convenient sample of n=233 inbound tourists to South Africa. Exploratory Factor Analysis and Multiple Regression Analysis were employed, utilising the Statistical Package for Social Sciences (SPSS 25.0) to analyse the data. The study found evidence of a statistically significant relationships between South Africa‟s Socio-cultural and Tourism place brand aspects, and business tourism to the country. These findings suggest that South Africa‟s place brand is an inferential heuristic cue that may have a halo effect on the predilections of business-oriented tourists.
Genome-Wide Identification of Epigenetic Regulators in Quercus suber

Modifications of DNA and histones, including methylation and acetylation, are critical for the epigenetic regulation of gene expression during plant development, particularly during environmental adaptation processes. However, information on the enzymes catalyzing all these modifications in perennial trees, such as Quercus suber, is still not available. In this study, several epigenetic modifier proteins, including eight DNA methyltransferases (DNA Mtases), three DNA demethylases (DDMEs) and ninety-one histone modifiers including thirty-five histone methyltransferases (HMTs), twenty-six histone demethylases (HDMTs), eight histone acetyltransferases (HATs) and twenty-two histone acetylases (HDACs) were identified in Q. suber. Phylogenetic analyses of the DNA and histone modifier proteins were performed using several plant species homologs, enabling the classification of the Q. suber proteins. Additional in silico analysis showed that some Q. suber DNA Mtases, DMEs and histone modifiers have the typical domains found in the plant model Arabidopsis, which might suggest a conserved functional role. A link between the expression levels of each gene in different Q. suber tissues (buds, flowers, acorns, embryos, cork and roots) with the functions already known for their closest homologs in other species was also established. Therefore, the data generated here are important for future studies exploring the role of epigenetic regulators in this economically important species.
Keep in Mind: Cyclophosphamide as Effective and Safe Therapeutic Option in Severely Active Crohn's Disease

T he broad spectrum of chronic inflammatory bowel diseases encompasses the two main entities: Crohn’s disease (CD) and ulcerative colitis (UC). The course of disease may be intermittent or chronic. Activity ranges from mild to severe and can in some instances be fulminant. Prognostic risk factors for a disabling course seem to be small bowel involvement, a stricturing or penetrating behaviour, perianal disease, onset at an age of less than 40 years and the need for systemic steroids for treating the first flare. The etiology of inflammatory bowel disease (IBD) is complex and many aspects still remain unclear. A healthy intestinal mucosa is in a state of controlled inflammation regulated by a delicate balance of proand anti-inflammatory cytokines. In Crohn’s disease the interaction of the intestinal mucosal immune system and the intestinal milieu seems to culminate in a sustained activation of an immune response with an uncontrolled deregulation of proand anti-inflammatory agents, resulting in ongoing mucosal damage. Understanding the mechanism of induction and maintenance of remission in Crohn’s disease at intestinal interfaces is a prerequisite to the evaluation of new therapeutic options. Rapid action and long term duration is the goal in most therapeutic approaches in chronic inflammation for induction and maintenance of remission. The search for new drugs has resulted in the evaluation of new immunosuppressive and anti-inflammatory agents including biological therapies targeting specific molecules. Among these, particularly the TNF-α blockers infliximab and adalimumab have a record of a sustained and extended response in Crohn’s disease. Efficacy and safety were evaluated in several studies in the last decade (Present et al. 1999; Sandborn et al. 2002; Hanauer et al. 2002; Hanauer et al. 2006; Clark 2006; INFLAMMATORY BOWEL DISEASE: A PRACTICAL APPROACH, SERIES #58