Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors associated with mammography adherence among married Chinese women in Yanbian, China.

BACKGROUND Despite the efficacy of regular mammograms, the incidence and mortality rate of breast cancer have been increasing in China. Insufficient studies on the factors affecting mammography adherence in Chinese married women have been conducted. The purpose of the present study was to explore the factors associated with adherence to guidelines for regular mammography among Chinese married women. MATERIALS AND METHODS The participants were recruited conveniently and included Chinese and Korean Chinese women who were married, living at Yanbian City in China. Demographic information, status regarding eight risk factors of breast cancer, health responsibility, and perceived benefits/barriers of mammography were obtained. Descriptive analyses, t-test, and multivariate analysis were performed. Hierarchical logistic regression was conducted to explore the factors associated with regular mammography adherence in Chinese and Korean Chinese subgroups. RESULTS About 24% of the sample population was adherent in going for regular mammography. The adherent group was significantly more educated, had more children, and had a lower proportion experiencing early menarche and a greater menopausal proportion than the non-adherent group. The final model using logistic regression analysis showed that being Chinese [OR=2.199 (1.224-3.951)], having no or one child [OR=4.879 (1.835-12.976)], early menarche [OR=3.515 (1.057-11.694)], being menopausal [OR=3.120 (0.965-10.088)], aged 40-49 [OR=2.374 (1.099-5.124)], having low education [OR=0.400 (0.211-0.765)], and perceiving greater benefits in doing mammography [OR=1.080 (1.014-1.151)] were significantly associated with mammography adherence, after controlling for covariates. CONCLUSIONS Sociocultural sensitive intervention for minorities should be emphasized when improving the adherence of regular mammography. Intervention tailored for women with lower education should be delivered and the benefits of mammography should be propagated to women in rural areas of China.
A TRPC1/TRPC3-mediated Increase in Store-operated Calcium Entry Is Required for Differentiation of H19-7 Hippocampal Neuronal Cells*♦

Store-operated calcium entry (SOCE) and TRPC protein expression were investigated in the rat-derived hippocampal H19-7 cell line. Thapsigargin-stimulated Ba2+ entry and the expression of TRPC1, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7 mRNA and protein were observed in proliferating H19-7 cells. When cells were placed under differentiating conditions, a change in TRPC homolog expression profile occurred. The expression of TRPC1 and TRPC3 mRNA and protein dramatically increased, while the expression of TRPC4 and TRPC7 mRNA and protein dramatically decreased; in parallel a 3.4-fold increase in the level of thapsigargin-stimulated Ba2+ entry was observed and found to be inhibited by 2-aminoethoxydiphenylborane. The selective suppression of TRPC protein levels by small interfering RNA (siRNA) approaches indicated that TRPC1 and TRPC3 are involved in mediating SOCE in proliferating H19-7 cells. Although TRPC4 and TRPC7 are expressed at much higher levels than TRPC1 and TRPC3 in proliferating cells, they do not appear to mediate SOCE. The co-expression of siRNA specific for TRPC1 and TRPC3 in proliferating cells inhibited approximately the same amount of SOCE as observed with expression of either siRNA alone, suggesting that TRPC1 and TRPC3 work in tandem to mediate SOCE. Under differentiating conditions, co-expression of siRNA for TRPC1 and TRPC3 blocked the normal 3.4-fold increase in SOCE and in turn blocked the differentiation of H19-7 cells. This study suggests that placing H19-7 cells under differentiating conditions significantly alters TRPC gene expression and increases the level of SOCE and that this increase in SOCE is necessary for cell differentiation.
Union Affiliation, Socialization, and Political Identities: The Case of Mexico

Abstract The literature on voting behavior has generally accepted that party identification largely determines voter choice. While many studies have found that party identification is largely transmitted through social learning, less studied are the processes of the construction of party identity by way of group membership. This study seeks to understand how group identity influences party identification among Mexican workers through an analysis of the effects of union affiliation on political behavior. It assesses the utility of corporatist legacies in explaining party identity in Mexico and provides a first assessment of party affinities among independent unionists. The evidence draws from original survey data collected during six demonstrations in Mexico City. The study finds that union membership does condition the party identity of corporatist workers but not that of independent unionists.
Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo.

Although murine tumor cells have been transfected to express a multitude of different cytokines and shown to be rejected in vivo, it is unclear which of these factors might be useful to facilitate tumor Ag immunization schemes. A study of the normal immune mechanisms involved in tumor rejection when it naturally occurs should reveal critical signals for generation of antitumor CTL in vivo. The highly transfectable variant of P815, P1.HTR, was found to be rejected in the hind footpads by approximately one-third of syngeneic DBA/2 mice. Analysis of draining popliteal lymph nodes revealed a large influx of CD4+ and CD8+ T lymphocytes in all mice, indicating that a failure to reject was not due to the complete absence of an inflammatory response. However, although IL-2 and IL-3 were produced by lymph node cells from all mice, only approximately one-third generated a high IFN-gamma response. IL-4 was not detected. To explore a role for IL-12 in the induction of the IFN-gamma-producing phenotype, a histidine-tagged IL-12 fusion protein was expressed in mammalian cells and purified by nickel-chelate chromatography, and a rabbit antiserum was produced. Neutralization of IL-12 in vivo eliminated the high IFN-gamma response and prevented rejection of P1.HTR tumors and also of a more immunogenic tum- variant of P815, P198. Conversely, exogenous IL-12 delivered early during challenge with P1.HTR cells induced high IFN-gamma production and resulted in tumor rejection in most mice. Therefore, endogenous IL-12 is vital for the rejection of these tumors when it naturally occurs, supporting a role for exogenous administration of this cytokine to favor a Th1-like phenotype in the immunotherapy of cancer.
Free automotive unions, industrial work and precariousness in provincial Russia

ABSTRACT This article draws on ethnographic work carried out since 2009 on workers and automotive unions in Kaluga, Russia. The contrast between secure and temporary contract workers in foreign-owned car plants is a focus of activism among emerging alternative trade unions in Kaluga. Workers in both the ‘new’ production-scape of high-tech foreign-owned automotive assembly, and the ‘old’ low-tech Soviet production contexts articulate similar interpretive understandings of what constitutes ‘precarious’ work: lack of autonomy and the lack of a ‘social wage’ generally in labour. We interrogate this through in-depth interviews with unionised and non-unionised workers in the auto sector and other industries locally. A divide emerges between workers who go to work for the car plants, and those who remain in Soviet-types firms and who reject the labour relations model that it offers and which they understand to contrast with a traditional ‘paternalistic’ Russian model.
Factors influencing persistent organic pollutant concentrations in the Atlantic white‐sided dolphin (Lagenorhynchus acutus)

Assessing the trends of persistent organic pollutants (POPs) in cetaceans is difficult because of age and gender influences on accumulation. Persistent organic pollutants bioaccumulate and are poorly metabolized; hence, concentrations may increase with age in males while females reduce their POP burden through parturition and lactation. Age and gender effects on contaminant concentrations are species specific because of life history and reproductive strategies. These influences must be understood in order to elucidate and assess lifetime POP exposure. The objectives of this study were to determine baseline POP concentrations in blubber samples from the Atlantic white‐sided dolphin (Lagenorhynchus acutus) and to investigate life history and other influences, such as metabolism, on these concentrations. Forty‐seven L. acutus blubber samples collected from mass stranding events in Massachusetts, USA (1993–2000), and archived in the National Marine Mammal Tissue Bank at the National Institute of Standards and Technology (Gaithersburg, MD, USA) were analyzed for 55 polychlorinated biphenyl congeners (PCB; 55 congeners), five polybrominated diphenyl ether (PBDE) congeners, and organochlorine pesticides (toxaphene, DDT and metabolites, mirex, dieldrin, chlordanes, hexachlorocyclohexanes, hexachlorobenzene, and endosulfans) by gas chromatography/mass spectrometry (GC‐MS). Ages for 19 animals were determined from growth layer groups on decalcified, stained thin tooth sections. Total PCBs (ΣPCB; sum of 55 congeners) were the contaminants present in the highest concentrations in all age classes (0.5–63 μg/g wet mass) followed by sum of DDTs (0.50–43 μg/g wet mass), toxaphene (0.055–31 μg/g wet mass), chlordanes (0.30–24 μg/g wet mass), and PBDEs (0.12–4.0 μg/g wet mass). Body length had a greater statistical influence than age on contaminant burdens in L. acutus. Contaminant burdens decreased with length in both male and female L. acutus, suggesting metabolic elimination and/or growth dilution in males and off‐loading via lactation in females.
To explore and to serve - Robotics between basic research and the actually useful

There is a wide gap between today's actually working vacuum cleaning robots and the robot butlers hailed by the popular press since the early 20th century. Robotics research it seems has still not managed to put right its perceived image in the eye of the general public and is too often still chasing cheap headlines rather than solid science. In this paper we will take a critical look at some aspects of current advanced robotics research and its presentation to the general public.
Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population

We performed a linkage analysis on 23 Finnish families with bipolar disorder and originating from the North‐Eastern region of Finland, using the Illumina Linkage Panel IV (6K) Array with an average intermarker spacing of 0.65 cM across the genome. We detected genome‐wide significant evidence for linkage of mood disorder (bipolar disorder type I, II, or not otherwise specified, manic type of schizoaffective psychosis, cyclothymia, or recurrent depression) to chromosomes 7q31 (LOD = 3.20) and 9p13.1 (LOD = 4.02). Analyzing the best markers on the complete set of 179 Finnish bipolar families supported the findings on chromosome 9p13 (maximum LOD score of 3.02 at position 383 Mb, immediately upstream of the centromere). This region harbors several interesting candidate genes, including contactin associated protein‐like 3 (CNTNAP3) and aldehyde dehydrogenase 1 (ALDH1B1). For the 7q31 locus, only one extended pedigree and ten families originating from the same late settlement region in North‐Eastern Finland provided evidence for linkage, suggesting that a gene predisposing to bipolar disorder is enriched in that region. Candidate genes of interest in this locus include potassium‐voltage‐gated channel, member 2 (KCND2) and calcium‐dependent activator protein for secretion 2 (CADPS2). The loci on the centromeric region of 9p13 and the telomeric region of 7q31 may represent susceptibility loci for mood disorder in the Finnish population. © 2009 Wiley‐Liss, Inc.
The Use of Bone Morphogenetic Protein Gene Therapy in Craniofacial Bone Repair

&NA; Bone morphogenetic proteins (BMPs) are capable of inducing endochondral bone formation when applied on biologic carriers in numerous mammalian in vivo assay systems. Bone morphogenetic protein gene therapy is also currently being developed to promote osteogenesis for clinical indications such as spinal fusions, craniofacial bone loss, and osteoporosis. In this study, critical‐sized mandibular defects were treated with a control adenoviral vector (Ad‐&bgr;‐gal), a BMP‐2 adenoviral vector (Ad‐BMP‐2), or a BMP‐9 adenoviral vector (Ad‐BMP‐9). Gross tissue examination, radiographic analysis, and histologic analysis demonstrated significant bony healing in the BMP treated groups compared to controls. Osteogenesis was limited to the bony defect, without extension into the surrounding soft tissues. The study suggests that with further development, BMP gene therapy may be potentially useful for repair of bony defects in the craniofacial region.
Student Financing of Higher Education in Washington: An Analysis of the Resources Used by Students in Paying for Their College Educations.

Presented in this document are the results of a study that had as its purpose to discover the means that college students in Washington State use in financing their educations. Findings include: (1) almost 50% of the students reported 1971 parental income of between $9,000 and $18,000; (2) over 50% of the students work during the school year with the average hours of employment falling between 15 and 20 hours per week; (3) students' earnings are the primary source of money to pay for their educations; (4) 25% of the students reported borrowing money at some time during their academic careers; (5) over 50% of the respondents considered themselves primarily self-supporting; (6) under 20% of the survey population described themselves as recipients of student financial aid; and (7) veterans comprise 16.9% of the total survey population. Other chapters deal with the cost of going to college, the resources available to pay off college, parental contributionsi distribution of student aid, projecting student needs, and the Federally Insured Student Loan Program in Washington. (HS) FILMED FROM BEST AVAILABLE COPY
A Model for the Stoichiometric Regulation of Blood Coagulation*

We have developed a model of the extrinsic blood coagulation system that includes the stoichiometric anticoagulants. The model accounts for the formation, expression, and propagation of the vitamin K-dependent procoagulant complexes and extends our previous model by including: (a) the tissue factor pathway inhibitor (TFPI)-mediated inactivation of tissue factor (TF)·VIIa and its product complexes; (b) the antithrombin-III (AT-III)-mediated inactivation of IIa, mIIa, factor VIIa, factor IXa, and factor Xa; (c) the initial activation of factor V and factor VIII by thrombin generated by factor Xa-membrane; (d) factor VIIIa dissociation/activity loss; (e) the binding competition and kinetic activation steps that exist between TF and factors VII and VIIa; and (f) the activation of factor VII by IIa, factor Xa, and factor IXa. These additions to our earlier model generate a model consisting of 34 differential equations with 42 rate constants that together describe the 27 independent equilibrium expressions, which describe the fates of 34 species. Simulations are initiated by “exposing” picomolar concentrations of TF to an electronic milieu consisting of factors II, IX, X, VII, VIIa, V, and VIIII, and the anticoagulants TFPI and AT-III at concentrations found in normal plasma or associated with coagulation pathology. The reaction followed in terms of thrombin generation, proceeds through phases that can be operationally defined as initiation, propagation, and termination. The generation of thrombin displays a nonlinear dependence upon TF, AT-III, and TFPI and the combination of these latter inhibitors displays kinetic thresholds. At subthreshold TF, thrombin production/expression is suppressed by the combination of TFPI and AT-III; for concentrations above the TF threshold, the bolus of thrombin produced is quantitatively equivalent. A comparison of the model with empirical laboratory data illustrates that most experimentally observable parameters are captured, and the pathology that results in enhanced or deficient thrombin generation is accurately described.
The Flow of Ethnicity: Voices of Diverse High School Youth.

This paper considers whether ethnicity is a social construction that is constantly being recreated in a nexus of shifting social relations rather than a set of perceptions and behaviors that remain constant and stem from a youth's membership in an ethnic group. Student responses about ethnicity from a larger study of student role and engagement in school provided impetus for this research, which used case studies of 10 students in urban high schools in California. The students, freshmen when the study began, include: (1) four Mexican American females; (2) two Vietnamese immigrant females; (3) two African American males; (4) one Italian American male; and (5) one Anglo American female. Semistructured interviews, school and classroom observations and analyses of student records provide information about student experiences of ethnicity. The case studies support the view that what happens in schools does affect students' senses of themselves and their identities. The meaning of ethnicity is constantly renegotiated as students interact with teachers and peers in classrooms and at home. This research also suggests that teachers car work positively with youth who experience racism. There is a 29-item bibliography. (SLD) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. **x******************************************************************* CRC Center for Research on the Context of Secondary Teaching School of Education, CERAS Building, Stanford University, Stanford, CA N305-3084 ME FLOW OF EMN1CI1'Y: VOICES OF DIVERSE HIGH SCHOOL YOUTH uPERMISSION TO REPRODUCE THIS MATERIAL IN MICROFICHE ONLY HAS BEEN GRANTED BY d SO ejf TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC). " P91-128 Ann Locke Davidson Hanh Thanh Cao Patricia X Phelan U.S. DEPARTMENT OF EDUCATION OtIff e of Educational Research and Improvement EDUCATIONAL RESOURCES INrORMATION CENTER (ERIC n This document has bee reproduced as received trom the persoi or organizalion originating 4,v1inor changes have beer rade to improve reoroduction qualdy Poinls ol view or opinionS s lied in ! his docu menl do not necessarily epresent officlai OEM position or policy 2 BEST COPY AVAILABLE ME FLOW OF EMNICITY: VOICES OF DIVERSE HIGH SCHOOL YOUTH
Prediction of Clinical Response After 1 Year of Infliximab Therapy in Rheumatoid Arthritis Based on Disease Activity at 3 Months: Posthoc Analysis of the RISING Study

Objective. To investigate the probability of clinical remission (REM) or low disease activity (LDA) after 1 year of infliximab (IFX) therapy based on disease activity at 3 months in patients with rheumatoid arthritis (RA). Methods. Methotrexate-refractory patients with RA received 3 mg/kg of IFX at weeks 0, 2, and 6, followed by 3 mg/kg, 6 mg/kg, or 10 mg/kg every 8 weeks from Week 14 (W14) to Week 46. Correlation of disease activity at W14 with disease activity at W54 and probability of REM/LDA at W54 were analyzed in each dosing group. Results. Disease activities at W14 were significantly correlated with both disease activity at W54 and probability of REM/LDA at W54 in patients continuing 3 mg/kg as well as in those receiving 6 mg/kg or 10 mg/kg therapy from W14. Results showed that, if approximate REM or LDA had not been achieved by W14, > 50% of patients continuing 3 mg/kg therapy would not be able to achieve REM or LDA at W54. However, even in patients with high or moderate disease activity at W14, dose escalation to 6 mg/kg or 10 mg/kg enabled many to achieve REM/LDA. Conclusion. Disease activity at W14 in standard-dose IFX therapy enabled the prediction of longterm clinical response at continued standard dose, as well as subsequent escalated-dose regimens. Disease activity at W14 was hypothesized to be an important index for IFX treatment strategy.
Comparison of binding affinities of omega-conotoxin and amlodipine to N-type Ca2+ channels in rat brain.

AIM To compare the binding affinities of omega-conotoxin (CTX) and amlodipine to N-type Ca2+ channels in rat brains. METHODS Whole rat brains were homogenized in HEPES buffer 50 mmol.L-1 (pH 7.4) and centrifuged at 40,000 x g to obtain the membrane-entriched fraction. 125I-omega-conotoxin (125I-omega-CTX) was used as a radioligand. Using radioligand binding assay Kd and Bmax values of the radioligand were determined by Scatchard analysis. The IC50 value for each drug was obtained from displacement experiments. RESULTS No differences in Bmax values of 125I-omega-CTX binding sites between frozen and fresh tissues were observed. Values of Kd and Bmax of N-type Ca2+ channels were 0.02 +/- 0.01 nmol.L-1 and 1029 +/- 108 pmol/g protein, respectively. The pKi values of omega-CTX and amlodipine were 9.57 and less than 4, respectively. The pKi values of propranolol, prazosin, atropine, and histamine were very low. CONCLUSION The binding affinity of the L-type Ca(2+)-antagonist amlodipine to N-type Ca2+ channels in the rat brain was very low.
Monitoring Circadian Rhythms of Individual Honey Bees in a Social Environment Reveals Social Influences on Postembryonic Ontogeny of Activity Rhythms

Social factors constitute an important component of the environment of many animals and have a profound influence on their physiology and behavior. Studies of social influences on circadian rhythms have been hampered by a methodological trade-off: automatic data acquisition systems obtain high-quality data but are effective only for individually isolated animals and therefore compromise by requiring a context that may not be sociobiologically relevant. Human observers can monitor animal activity in complex social environments but are limited in the resolution and quality of data that can be gathered. The authors developed and validated a method for prolonged, automatic, high-quality monitoring of focal honey bees in a relatively complex social environment and with minimal illumination. The method can be adapted for studies on other animals. The authors show that the system provides a reliable estimation of the actual path of a focal bee, only rarely misses its location for > 1 min, and removes most nonspecific signals from the background. Using this system, the authors provide the first evidence of social influence on the ontogeny of activity rhythms. Young bees that were housed with old foragers show ~24-h rhythms in locomotor activity at a younger age and with stronger rhythms than bees housed with a similar number of young bees. By contrast, the maturation of the hypopharyngeal glands was slower in bees housed with foragers, similar to findings in previous studies. The morphology and function of the hypopharyngeal glands vary along with age-based division of labor. Therefore, these findings indicate that social inhibition of task-related maturation was effective in the experimental setup. This study suggests that although the ontogeny of circadian rhythms is typically correlated with the age-based division of labor, their social regulation is different.