Miracle-dz/UniFAR-FTUs huggingface dataset:
A hybrid evolutionary algorithm for community detection

Evolutionary algorithm belongs to the behaviorism which is one of major approaches to artificial intelligence. Community detection is one of the important applications of the evolutionary algorithm. Detecting the community structure, an essential property for complex networks, can help us understand the inherent functions of real systems. It has been proved that genetic algorithm (GA) is feasible for community detection, and yet existing GA-based community detection algorithms still need improving in terms of their robustness and accuracy. A Physarum-based network model (PNM) with an intelligence of recognizing inter-community edges based on a kind of multi-headed slime mold, has been proposed in the phase of GA's initialization for optimization. In this paper, integrated with PNM after three operators of GA during the process of community detection, a novel genetic algorithm, called P-GACD, is proposed to improve the efficiency of GA for community detection. In addition, some experiments are implemented in five real-world networks to evaluate the performance of P-GACD. The results reveal that P-GACD shows an advantage in terms of the robustness and accuracy, contrasted with the existing algorithms.
Differential Response of Human Hepatocyte Chromatin to HDAC Inhibitors as a Function of Microenvironmental Glucose Level

Diabetes is a complex multifactorial disorder characterized by chronic hyperglycemia due to impaired insulin secretion. Recent observations suggest that the complexity of the disease cannot be entirely accounted for genetic predisposition and a compelling argument for an epigenetic component is rapidly emerging. The use of histone deacetylase inhibitor (HDACi) in clinical setting is an emerging area of investigation. In this study, we have aimed to understand and compare the response of hepatocyte chromatin to valproic acid (VPA) and trichostatin A (TSA) treatments under normoglycemic or hyperglycemic conditions to expand our knowledge about the consequences of HDACi treatment in a diabetes cell model. Under normoglycemic conditions, these treatments promoted chromatin remodeling, as assessed by image analysis and H3K9ac and H3K9me2 abundance. Simultaneously, H3K9ac marks shifted to the nuclear periphery accompanied by HP1 dissociation from the heterochromatin and a G1 cell cycle arrest. More striking changes in the cell cycle progression and mitotic ratios required drastic treatment. Under hyperglycemic conditions, high glucose per se promoted chromatin changes similar to those promoted by VPA and TSA. Nonetheless, these results were not intensified in cells treated with HDACis under hyperglycemic conditions. Despite the absence of morphological changes being promoted, HDACi treatment seems to confer a physiological meaning, ameliorating the cellular hyperglycemic state through reduction of glucose production. These observations allow us to conclude that the glucose level to which the hepatocytes are subjected affects how chromatin responds to HDACi and their action under high‐glucose environment might not reflect on chromatin remodeling. J. Cell. Physiol. 231: 2257–2265, 2016. © 2016 Wiley Periodicals, Inc.
NG2 Proteoglycan Expression in Mouse Skin: Altered Postnatal Skin Development in the NG2 Null Mouse

In early postnatal mouse skin, the NG2 proteoglycan is expressed in the subcutis, the dermis, the outer root sheath of hair follicles, and the basal keratinocyte layer of the epidermis. With further development, NG2 is most prominently expressed by stem cells in the hair follicle bulge region, as also observed in adult human skin. During telogen and anagen phases of the adult hair cycle, NG2 is also found in stem cell populations that reside in dermal papillae and the outer root sheaths of hair follicles. Ablation of NG2 produces alterations in both the epidermis and subcutis layers of neonatal skin. Compared with wild type, the NG2 null epidermis does not achieve its full thickness due to reduced proliferation of basal keratinocytes that serve as the stem cell population in this layer. Thickening of the subcutis is also delayed in NG2 null skin due to deficiencies in the adipocyte population.
A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers.

AIMS The aim of this study was to compare the cardiovascular effects of levobupivacaine with those of rac-bupivacaine following i.v. administration to 14 healthy male volunteers. METHODS Drugs were infused (at 10 mg min(-1)) using a randomized, double-blind, complete crossover procedure with a washout period of at least 1 week. The administration of drug was discontinued on the appearance of defined CNS symptoms or when a total of 150 mg had been given. Parameters measured were arterial blood pressure, heart rate, ECG, ejection fraction, acceleration index, stroke index and cardiac index. RESULTS The mean doses administered were 56.1 mg and 47.9 mg for levobupivacaine and rac-bupivacaine respectively and the maximum mean plasma concentrations were 2.62 and 2.25 microg ml(-1) respectively. Despite the dose and plasma concentrations being comparable, levobupivacaine produced a statistically significant smaller reduction in mean stroke index (-5.14 vs -11.86 ml m(-2), P=0.001), acceleration index (-0.09 vs -0.20 s(-2), P=0.011) and the ejection fraction (-2.50 vs -4.29%, P=0.024). Both levobupivacaine (non significant) and rac-bupivacaine (significant) produced small increases in the PR interval and the corrected QT interval and although the effects of rac-bupivacaine appeared to be greater the difference between the two drugs was not significant. CONCLUSIONS In conclusion, this study has shown that following i.v. administration levobupivacaine produces significantly less effects on cardiovascular function than does rac-bupivacaine. In particular the negative inotropic effect for levobupivacaine was less than that for rac-bupivacaine as indicated by changes in stroke index, acceleration index and ejection fraction.
Standard FPGA-based or Full FPGA-based Controllers for Electrical systems, two viable solutions

This paper presents a comparison between a standard FPGA-based controller and a full FPGA-based controller for electrical systems. The first controller uses a standard low cost FPGA such as Xilinx Spartan and the second one uses an Actel Fusion FPGA which integrates all the peripherals required for these kinds of applications. The purpose here, is to analyze in details the potential benefits offered by this last solution compared to the first one. To this purpose, a current control algorithm for AC drives has been implemented on both targets. This comparison concerns the design methodology (evaluation of the reusability of designs), the time/area performances and also the quality of the system control.
Integrated passive devices (IPD) integration with eWLB (embedded wafer level BGA) for high performance RF applications

The demand for wireless communications is increasing through use of smart phones, 3G handsets wherein high speed and reliable data communication are crucial requirements. Multi-bands networks help to facilitate these at higher range of radio frequencies. In many wireless communications, power amplifiers (PA) are used to increase the amplitude of relatively weak signals. These PAs depend on matching circuits that generally include capacitor and inductors, to match the impedances of the power amplifier to other radio components. The reduction in cost and die size of multi-mode power amplifiers and matching networks in RF functional blocks is highly desired. So they need to be designed with high efficiency and be integrated for optimum performance. eWLB technology provides the solution for multi die integration. It enables small form-factor and good electrical performance using well controlled wafer fab process and fine line width/spacing. In this work, multi-die eWLB has been successfully developed where both PA die and IPD die for impedance matching network have been placed side-by side, thus providing better multi-chip packaging solution with better performance. Simulation, characterization and design work for PA and IPD integration in eWLB packaging are presented in this paper. The developed IPD mainly consists of inductors resistors, and capacitors for target impedance matching with PA. Simulation results show that the optimized IPD design change improves impedance more than 10% to meet the target impedance which helps to achieve the optimum power amplifier output impedance and maximum output power. Modified inductor design tuning shows significant improvement in impedance values of power amplifier and also enables overall good performance of the eWLB packaging. And package level reliability test results are also presented in this paper.
European qualifiers to the 2018 FIFA World Cup can be manipulated

Tournament organizers supposedly design rules such that a team cannot be better off by exerting a lower effort. It is shown that the European qualifiers to the 2018 FIFA World Cup are not strategy-proof in this sense: a team might be eliminated if it wins in the last matchday of group stage, while it advances to play-offs by playing a draw, provided that all other results do not change. An example reveals that this scenario could have happened in October 2017, after four-fifth of all matches have already been played. We present a model and identify nine incentive incompatible qualifiers to recent UEFA European Championships or FIFA World Cups. A mechanism is suggested in order to seal the way of manipulation in group-based qualification systems.
Loss and heat computations of damper bars in large tubular hydro-generator

To research the loss and heat of damper bars thoroughly, a 2D electromagnetic field FE model of tubular hydro-generator and a 3D temperature field FE model of the rotor are built up respectively. The factors such as rotor motion and nonlinearity of the time-varying electromagnetic field, the anisotropic heat conduction of the rotor core lamination and different heat dissipation conditions on the windward and lee side of the poles are considered. Furthermore, according to the different operating conditions, different rotor structures and materials, compositive calculations about the losses and temperatures of the damper bars of a 36 MW generator are carried out, and the data are compared with the test. The results show that the computation precision is satisfied and the generator design is reasonable.
A highly linear 84 GHz low noise amplifier MMIC in AlGaN/GaN HEMT technology

AlGaN/GaN-based high electron mobility transistors, when scaled to small gate lengths, may exploit the material's high speed properties to achieve operating frequencies in the high millimeter-wave frequency range. Besides power amplification, these transistors can also be used to implement low noise amplifiers, which profit from the high breakdown voltages in terms of amplifier linearity and robustness. This paper presents the design, implementation and measured performance of a 84 GHz low noise amplifier MMIC in a new AlGaN/GaN on s.i. SiC HEMT technology with 100 nm gate length and maximum cutoff frequencies ƒT and ƒmax of 80 and >200 GHz, respectively. The amplifier achieves over 25 dB gain and 5.6 dB noise figure at 84 GHz. At a drain bias of 10 V, its output-related 1-dB compression point lies at +15 dBm, well beyond that of competing semiconductor technologies.
Enhanced production of IL‐8 in chronic but not in early ileal lesions of Crohn's disease (CD)

Distinct Th1/Th2 patterns have been observed during the evolution of CD. The aim of this study was to compare neutrophil involvement and IL‐8 mRNA and protein expression during early recurrent lesions and chronic phases of CD. Twenty‐nine patients with CD having ileocolonic resection with anastomosis were studied. Biopsies were obtained during surgery from the non‐inflamed ileal mucosa and from chronic ileal lesions. Endoscopic ileal biopsies were also taken from early recurrent ileal lesions occurring 3 months after surgery. Neutrophil counts were performed and mucosal IL‐8 levels were evaluated by competitive reverse transcriptase‐polymerase chain reaction and immunohistochemistry. Early recurrent ileal lesions were characterized by low neutrophil counts and IL‐8 production at the mRNA and protein levels compared with the ileal chronic lesions. The main cellular sources of IL‐8 in the early recurrent lesions were neutrophils, while in chronic lesions the majority of IL‐8‐stained cells were CD3+ T cells and macrophages. These results confirmed that the nature of the inflammatory infiltrate and the expression of cytokine profiles may differ between the acute and chronic phases of CD.
Squamous cell differentiation markers in normal, premalignant, and malignant epithelium: Effects of retinoids

Vitamin A and some of its analogs (retinoids) maintain normal differentiation of epithelial tissues by preventing aberrant squamous differentiation of cells in nonkeratinizing epithelia. They can also reverse squamous metaplasia, which develops in vivo during vitamin A deficiency. These effects are the result of the ability of retinoids to suppress the expression of genes associated with squamous differentiation (e.g., transglutaminase type I, loricrin, involucrin, filaggrin, and keratin K1). In addition, retinoids reverse keratinizing premalignant lesions in the oral cavity, and inhibit the growth and squamous differentiation of head and neck squamous cell carcinomas (HNSCCs) in vitro. Nuclear retinoic acid receptors, which function as DNA‐binding, trans‐acting, transcription‐modulating factors, are considered to be the proximate mediators of the effects of retinoids on gene expression and may mediate the re‐regulation of aberrant differentiation and growth of premalignant and some malignant cells, thereby suppressing the development of head and neck cancer.
Adequacy of pain management in HIV-positive patients

Methods: The Brief Pain Inventory (BPI) (short form) questionnaire was administered to 100 consecutive, consenting HIVpositive patients admitted to an urban district-level hospital in KwaZulu-Natal. Convenience sampling was employed with participants recruited on consecutive days. Data sources comprised patient interviews and review of hospital records. A Pain Management Index derived from the BPI was calculated to establish the adequacy of pain management. Descriptive statistics were tabulated for the recognition of pain, pain severity and appropriateness of analgesia. Correlation analyses were used to assess the association between pain and daily life.
Variations on the GFP Chromophore

We have determined to 2.1 Å resolution the crystal structure of a dark state, kindling fluorescent protein isolated from the sea anemone, Anemonia sulcata. The chromophore sequence Met63-Tyr64-Gly65 of the A. sulcata chromoprotein was previously proposed to comprise a 6-membered pyrazine-type heterocycle (Martynov, V. I., Savitsky, A. P., Martynova, N. Y., Savitsky, P. A., Lukyanov, K. A., and Lukyanov, S. A. (2001) J. Biol. Chem. 276, 21012–21016). However, our crystallographic data revealed the chromophore to comprise a 5-membered p-hydroxybenzylideneimidazolinone moiety that adopts a non-coplanar trans conformation within the interior of the GFP β-can fold. Unexpectedly, fragmentation of the polypeptide was found to occur within the chromophore moiety, at the bond between Cys62C and Met63N1. Our structural data reveal that fragmentation of the chromophore represents an intrinsic, autocatalytic step toward the formation of the mature chromophore within the specific GFP-like proteins.
Brain Angiotensin II, an Important Stress Hormone: Regulatory Sites and Therapeutic Opportunities

Abstract: The presence of a brain Angiotensin II (Ang II) system, separated from and physiologically integrated with the peripheral, circulating renin‐angiotensin system, is firmly established. Ang II is made in the brain and activates specific brain AT1 receptors to regulate thirst and fluid metabolism. Some AT1 receptors are located outside the blood‐brain barrier and are sensitive to brain and circulating Ang II. Other AT1 receptors, located inside the blood‐brain barrier, respond to stimulation by Ang II of brain origin. AT1 receptors in the subfornical organ, the hypothalamic paraventricular nucleus (PVN), and the median eminence are involved in the regulation of the stress response. In particular, AT1 receptors in the PVN are under glucocorticoid control and regulate corticotrophin‐releasing hormone (CRH) formation and release. In the PVN, restraint elicits a fast increase in AT1 receptor mRNA expression. The expression of paraventricular AT1 receptors is increased during repeated restraint and after 24 h of isolation stress, and their stimulation is essential for the hypothalamic‐pituitary‐adrenal axis activation, the hallmark of the stress response. Peripheral administration of an AT1 receptor antagonist blocks peripheral and brain AT1 receptors, prevents the sympathoadrenal and hormonal response to isolation stress, and prevents the gastric stress ulcers that are a characteristic consequence of cold‐restraint stress. This evidence indicates that pharmacologic inhibition of the peripheral and brain Ang II system by AT1 receptor blockade has a place in the prevention and treatment of stress‐related disorders.
Optimal Power Flow via Interior-Exterior Method

This paper presents a new approach to the resolution of the optimal power flow problem. In this approach the inequality constraints are treated by the modified barrier and primal-dual logarithmic barrier methods. The inequality constraints are transformed into equalities by introducing positive auxiliary variables, which are perturbed by the barrier parameter. A Lagrangian function is associated with the modified problem. The first-order necessary conditions are applied to the Lagrangian, generating a nonlinear system which is solved by Newton's method. The perturbation of the auxiliary variables results in an expansion of the feasible set of the original problem, allowing the limits of the inequality constraints to be reached. Numerical tests on the Brazilian CESP and South-Southeast systems and a comparative test indicated that the new approach efficiently resolves of the Optimal Power Flow problem.
DNA methylation: A promising target for the twenty-first century

Background: Over the last few years DNA methylation and its involvement in diseases such as cancer has become of great interest for applied research. Since reversal of aberrant DNA methylation may influence the behavior of tumors, the methylation of DNA CpG sites is a potential target for the development of inhibitors for use in cancer treatment. Objective/methods: We briefly review the structural and mechanistic features of DNA methylation, including a structural analysis of the three main human DNA methyltransferases and some (pre)clinical results. Results/conclusion: Despite side effects, data obtained to date still support the vision that DNA-methylation, possibly associated with the use of histone deacetylases (HDACs) and/or artificial transcription factors (ATFs), is a promising target for improving anticancer therapy in the 21st century.
Muerte regresiva del bosque inducida por el clima: ¿un fenómeno mundial en aumento?

America). Una introduccion a las pautas mundiales emergentes relativas a la muerte regresiva del bosque inducida por el clima. de agua para los vegetales. El recalentamiento mundial, los cambios en la composicion atmosferica (por ejemplo, el incremento de concentraciones de compuestos nitrogenados y de CO 2 originados por el enorme volumen de emisiones provenientes de las actividades humanas) y los aumentos locales de luz solar y precipitaciones han favorecido el crecimiento
Exertional rhabdomyolysis in quarter horses and thoroughbreds: one syndrome, multiple aetiologies.

The purpose of this study was to determine if chronic exertional rhabdomyolysis (ER) in Quarter Horses and Thoroughbreds represents one or several distinct myopathies. Eighteen Quarter Horses and 18 Thoroughbreds with ER were selected from cases presented to the Veterinary Hospital on the basis of a history of ER, assessment of muscle histopathology, and serum CK activity before and 4 h post exercise. In addition, 2 of 3 of the following parameters were evaluated: muscle glycogen concentrations, thyroid hormones (T3, T4), fractional excretion (FE) of sodium, potassium and chloride. The CK response to training, the metabolic response to a near maximal standardised exercise test (SET), blood glucose concentrations after an i.v. glucose challenge and a skeletal muscle in vitro caffeine contracture test were performed on 5 of the Quarter Horses, selected because of polysaccharide storage myopathy (PSSM), and 5 of the Thoroughbreds. Serum T3 and T4 were all within normal limits. Low FE of sodium and potassium were seen in < 20% of Quarter Horses and Thoroughbreds. Four hours post exercise, CK was increased in 77% of Quarter Horses and 72% of Thoroughbreds with ER. Muscle glycogen concentrations in Quarter Horses with ER were significantly higher than in normal Quarter Horses and Thoroughbreds with ER. No Thoroughbreds, but 15/18 Quarter Horses with ER had abnormal polysaccharide accumulation in muscle biopsies consistent with a diagnosis of PSSM. PSSM Quarter Horses had higher CK activity during training than Thoroughbreds and higher glycogen utilisation with the SET. PSSM Quarter Horses also had significantly enhanced glucose clearance compared to normal Quarter Horses and Thoroughbreds with ER. Thoroughbreds with ER had significantly lower thresholds for caffeine-induced contracture than normal horses and PSSM Quarter Horses. It was concluded that there are multiple causes for exertional rhabdomyolysis. In Quarter Horses, rhabdomyolysis is commonly due to a glycogen storage disorder, PSSM, and is readily expressed in untrained horses. In Thoroughbreds, ER is commonly due to an underlying abnormality of muscle contraction. Rhabdomyolysis in Thoroughbreds, however, is only expressed intermittently when key stressors are present.
14-MHz ultrasonography as an outcome measure in morphea (localized scleroderma).

of the skin lesions. Increased levels of serum HMGB1 have been reported in several diseases such as severe infection and/or sepsis, trauma, cancers, and systemic lupus erythematosus, which were not observed in our patients with MPE, EM, and SJS and/or TEN. It has been reported that granulysin and Fas ligand are possible candidates as biomarkers for early diagnosis of SJS and/or TEN, but the duration of elevated granulysin and Fas ligand levels is limited; therefore, falsenegative results for SJS and/or TEN could occur. In this regard, HMGB1 levels were high at the early stage of SJS and/or TEN and remained elevated even after the onset, which is in contrast to the kinetics of granulysin and Fas ligand. Although the numbers of patients with SJS and/or TEN were limited in this study, we propose that measurements of HGMB1 in combination with granulysin and/or Fas ligand would be a useful diagnostic tool for cases of SJS and/or TEN that require early diagnosis and treatment.