Miracle-dz/UniFAR-FTUs huggingface dataset:
Détection de situations à risque basée sur des détecteurs de mouvement à domicile pour les personnes dépendantes

Résumé. Avec le vieillissement de la population dans les décennies à venir, la prise en charge de la dépendance est devenu un enjeu majeur. Les nouvelles technologies permettent d’améliorer le confort et la sécurité des personnes dépendantes à domicile. Dans cet article nous proposons une méthode de détection de situations à risques basée sur le seuillage automatique des intervalles d’inactivité des capteurs de mouvement de type infrarouge passif. Notre contribution consiste à apprendre de façon automatique la durée maximale d’inactivité, par pièce et par plage horaire. La méthode est évaluée sur des données réelles provenant de l’activité d’une personne réelle dans un appartement équipé de capteurs domotiques. Notre approche permet de réduire le temps d’appel des secours.
Efficacy of oral ketoprofen in acute migraine: A double-blind randomized clinical trial

Background Certain nonsteroidal anti-inflammatory drugs are effective in the acute treatment of migraine attacks. The authors report a double-blind, placebo-controlled, randomized cross-over trial of a dual-release formulation of oral ketoprofen in the acute treatment of migraine attacks. Methods The authors compared the efficacy of two doses of ketoprofen (75 or 150 mg) with that of placebo (primary analysis) and zolmitriptan 2.5 mg (secondary analysis) on one to four consecutive attacks in 235 intent-to-treat patients (out of 257 randomized patients) with migraine with or without aura. The principal efficacy outcome was headache relief (reduction in headache severity from severe or moderate to mild or absent at 2 hours). Results Results are based on 838 attacks with a severe or moderate headache that were evaluable at 2 hours. Relief was reported for 62.6% of headaches treated with ketoprofen 75 mg, 61.6% with ketoprofen 150 mg, and 66.8% with zolmitriptan. The difference between the three active treatments and placebo (27.8% relief) was highly significant, both tests of ketoprofen vs placebo being globally controlled at a 5% level for the type I error (primary analysis). Headaches at 2 hours disappeared more frequently for the active treatments than for placebo. The authors also demonstrated efficacy on most other secondary outcomes. The tolerance of ketoprofen was good (similar to that of placebo). Conclusions Oral ketoprofen (75 mg or 150 mg) in a dual-release formulation is an effective and well-tolerated drug in the acute treatment of migraine attacks.
Probability , and Computing Solutions KW 41 HS 16 Solution of In-Class Exercise 1 : Lines Intersecting Segment

Solution of In-Class Exercise 1: Lines Intersecting Segment Let s be a line segment in the plane R, and let u, v 2 R be the two endpoints that delimit it. Let furthermore L be the set of all non-vertical lines l that intersect s. A simple characterization of L would be that any non-veritcal line l is contained in L if and only if one of the following occurs: (i) l contains u or (ii) l contains v or (iii) u lies above l and v lies below l or (iv) v lies above l and u lies below l. In the dual space, u and v are two xed lines and we are looking for the set of points L corresponding to the duals of all lines in L. According to Observation 2.3 and the preceding discussion, the above criteria for l hitting the segment s are satis ed if and only if in the dual, (i') l lies on u (incidence) or (ii') l lies on v (incidence) or (iii') l lies above u and l lies below v (2.3) or (iv') l lies above v and l lies below u (2.3) So the space L we are looking for consists of four regions de ned by these criteria. The following picture shows what those regions typically look like. On the left, the primal space is shown, containing a line segment s and several lines f, g, h intersecting s in exactly one point, where on the right their duals are shown. Here `s is the line going through the endpoints u and v. The set of points L consists of the two lines u and v as well as all points in the left wedge that have u above and v below (region (iv')) and all points in the right wedge that have v above and u below (region (iii')).
Formulas by synthetic asymptote for TM/sub 0/ surface wave pole locations of a microstrip substrate

It is convenient to have simple formulas to determine the pole locations of the surface wave in the Green's function instead of searching in spectral space. In many practical circuits, to avoid excessive radiation and surface wave losses, the frequency is kept low for a given substrate thickness. This leads to the existence of only one surface wave mode TM/sub 0/. The formula is synthesized from the asymptotes of the original transcendental equations. With the pole located it is easy to find the pole amplitude with existing formulas.
mHealth: a mechanism to deliver more accessible, more effective mental health care.

UNLABELLED The increased popularity and functionality of mobile devices has a number of implications for the delivery of mental health services. Effective use of mobile applications has the potential to (a) increase access to evidence-based care; (b) better inform consumers of care and more actively engage them in treatment; (c) increase the use of evidence-based practices; and (d) enhance care after formal treatment has concluded. The current paper presents an overview of the many potential uses of mobile applications as a means to facilitate ongoing care at various stages of treatment. Examples of current mobile applications in behavioural treatment and research are described, and the implications of such uses are discussed. Finally, we provide recommendations for methods to include mobile applications into current treatment and outline future directions for evaluation. KEY PRACTITIONER MESSAGE Mobile devices are becoming increasingly common among the adult population and have tremendous potential to advance clinical care. Mobile applications have the potential to enhance clinical care at stages of treatment-from engaging patients in clinical care to facilitating adherence to practices and in maintaining treatment gains. Research is needed to validate the efficacy and effectiveness of mobile applications in clinical practice. Research on such devices must incorporate assessments of usability and adherence in addition to their incremental benefit to treatment.
Evaluation of HLA-DRB1 imputation using a Finnish dataset.

Owing to the vast amount of alleles, high-resolution human leukocyte antigen (HLA) typing is expensive and time-consuming. Scientists have attempted to develop computational approaches to define HLA alleles with high confidence. We tested the reliability of HLA*IMP and SNP2HLA for imputing HLA-DRB1 alleles in a Finnish material (n=161). The per-individual success rates varied between 16.68% and 25.4% using both softwares. One of the most prominent example was HLA-DRB1*01:01 allele showing approximately a 30% success rate while being the most common wrongly imputed allele. In Finland, isolation and migration history have shaped the gene pool narrower showing HLA haplotype frequencies typical to the Finnish population when compared to Europeans. The imputation success for HLA-DRB1 alleles was very low pointing to the importance of population-specific reference material.
Comparative study of trajectories resulted from cell decomposition path planning approaches

This paper is devoted to a quantitative study of the sensitivity of cell decomposition path planning to various key criteria dealing with optimality and computational complexity. More specifically, the work analyzes the influence of various types of cell decomposition approaches (e.g. trapezoidal, rectangular) and cost functions used during the trajectory search phase (e.g. L1, L2 norms) in the performance of the whole path planning algorithm. This paper also addresses the generation of random environments where obstacles are randomly placed according to a dispersion factor. The included comparison among cell decomposition key criteria is based on numerous simulation experiments that also accounts for the number of obstacles in the environment.
L'analyse des séjours chirurgicaux au sein du PMSI : un nouvel indicateur pour l'observation des cancers

Avec 240 000 nouveaux cas estimes en 1995 (135 000 pour les hommes et 105 000 pour les femmes), le cancer, maladie grave par ses consequences somatiques, psychologiques, sociales et economiques est au cœur des preoccupations de sante publique.
Topic grouping by spectral clustering

With the growing number of web documents, it becomes difficult to analyze and obtain information from such an array of documents. Furthermore, unsupervised methods are preferable, as most web documents are unlabeled. Probabilistic topic modeling is one such method. It discovers latent structures among unstructured documents. While many traditional topic models usually assume that the topics are independent of each other, some models have been proposed to obtain correlations between the topics or a hierarchy of the topics. These models are designed to obtain both the topics and the correlations without using any other method. Therefore, very few studies apply other methods to determine a correlation between topics. In this paper, we apply spectral clustering to group the topics obtained from a traditional topic model, in this case the Latent Dirichlet Allocation model. To the best of our knowledge, this is the first approach that uses spectral clustering for the grouping of topics. We demonstrate the experimental results with various settings.
Open Reading Frame III of Borna Disease Virus Encodes a Nonglycosylated Matrix Protein

ABSTRACT The open reading frame III of Borna disease virus (BDV) codes for a protein with a mass of 16 kDa, named p16 or BDV-M. p16 was described as an N-glycosylated protein in several previous publications and therefore was termed gp18, although the amino acid sequence of p16 does not contain any regular consensus sequence for N glycosylation. We examined glycosylation of p16 and studied its membrane topology using antisera raised against peptides, which comprise the N and the C termini. Neither an N- nor a C-terminal peptide is cleaved from p16 during maturation. Neither deglycosylation of p16 by endoglycosidases nor binding of lectin to p16 was detectable. Introduction of typical N-glycosylation sites at the proposed sites of p16 failed in carbohydrate attachment. Flotation experiments with membranes of BDV-infected cells on density gradients revealed that p16 is not an integral membrane protein, since it can be dissociated from membranes. Our experimental data strongly suggest that p16 is a typical nonglycosylated matrix protein associated at the inner surface of the viral membrane, as is true for homologous proteins of other members of the Mononegavirales order.
Conventional transarterial chemoembolization vs microsphere embolization in hepatocellular carcinoma: a meta-analysis.

AIM To compare conventional transarterial chemoembolization (c-TACE) with microsphere embolization in hepatocellular carcinoma (HCC). METHODS We searched PubMed, Medline, Embase and the Cochrane Library for trials assessing the efficacy and safety of c-TACE in comparison with those of yttrium-90 microsphere or drug-eluting bead embolization from January 2004 to December 2013. Overall survival rate (OSR), tumor response [complete response, partial response (PR), stable disease (SD), progressive disease (PD)], α-fetoprotein (AFP) response, progression rate and complications were compared and analyzed. Pooled ORs with 95%CI were calculated using either the fixed-effects model or random-effects model. All statistical analyses were conducted using the Review Manager (version 5.1.) from the Cochrane collaboration. RESULTS Thirteen trials were identified, including a total of 1834 patients; 1233 were treated with c-TACE, 377 underwent yttrium-90 microsphere embolization and 224 underwent drug-eluting bead embolization. The meta-analysis with either the random-effects model or fixed-effects model indicated that microsphere embolization was associated with significantly higher OSRs compared with those of c-TACE (OR(1-year) = 1.38, 95%CI(1-year): 1.05-1.82; OR(2-year) = 2.88, 95%CI(2-year): 1.18-7.05; OR(3-year) = 2.15, 95%CI(3-year): 1.18-3.91). The complete tumor response rates of patients who underwent microspheres embolization were significantly higher than those of patients treated with c-TACE (OR = 2.19, 95%CI: 1.31-3.64). The tumor progression rate after microsphere embolization was markedly lower than that after c-TACE (OR = 0.56, 95%CI: 0.39-0.81). There was no significant difference between microsphere embolization and c-TACE in PR (OR = 0.73, 95%CI: 0.47-1.15), SD (OR = 1.07, 95%CI: 0.79-1.44), PD (OR = 0.75, 95%CI: 0.33-1.68), AFP response (OR = 1.38, 95%CI: 0.64-2.94) and complications (OR = 0.68, 95%CI: 0.46-1.00). CONCLUSION Our analysis indicated that microsphere embolization was associated with superior survival and treatment response in comparison with c-TACE in the treatment of patients with HCC.
MAP adaptation with subspace regression classes and tying

In the hidden Markov modeling framework with mixture Gaussians, adaptation is often done by modifying the Gaussian mean vectors using MAP estimation or MLLR transformation. When the amount of adaptation data is scarce or when some speech units are unseen in the data, it is necessary to do adaptation in groups-either with regression classes of Gaussians or via vector field smoothing. In this paper, we propose to derive regression classes of subspace Gaussians for MAP adaptation. The motivation is that clustering at the finer acoustic level of subspace Gaussians of lower dimension is more effective, resulting in lower distortions and relatively fewer regression classes. Experiments in which context-dependent TIMIT HMMs are adapted to the resource management task with few minutes of speech show improvement of our subspace regression classes over traditional full-space regression classes.
VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors

Sphingosine 1-phosphate (S1P) is a platelet-derived sphingolipid that binds to S1P1 (EDG-1) receptors and activates the endothelial isoform of NO synthase (eNOS). S1P and the polypeptide growth factor vascular endothelial growth factor (VEGF) act independently to modulate angiogenesis and activate eNOS. In these studies, we explored the cross-talk between S1P and VEGF signaling pathways. When cultured bovine aortic endothelial cells were treated with VEGF (10 ng/ml), the expression of S1P1 protein and mRNA increased by ≈4-fold. S1P1 up-regulation by VEGF was seen within 30 min of VEGF addition and reached a maximum after 1.5 h. By contrast, expression of neither bradykinin B2 receptors nor the scaffolding protein caveolin-1 was altered by VEGF treatment. The EC50 for VEGF-promoted induction of S1P1 expression was ≈2 ng/ml, within its physiological concentration range. S1P1 induction by VEGF was attenuated by the tyrosine kinase inhibitor genistein and by the PKC inhibitor calphostin C. Preincubation of bovine aortic endothelial cells with VEGF (10 ng/ml for 90 min) markedly enhanced subsequent S1P-dependent eNOS activation. VEGF pretreatment of cultured endothelial cells also markedly potentiated S1P-promoted eNOS phosphorylation at Ser-1179, as well as S1P-mediated activation of kinase Akt. In isolated rat arteries, VEGF pretreatment markedly potentiated S1P-mediated vasorelaxation and eNOS Ser-1179 phosphorylation. Taken together, these data indicate that VEGF specifically induces expression of S1P1 receptors, associated with enhanced intracellular signaling responses to S1P and the potentiation of S1P-mediated vasorelaxation. We suggest that VEGF acts to sensitize the vascular endothelium to the effects of lipid mediators by promoting the induction of S1P1 receptors, representing a potentially important point of cross-talk between receptor-regulated eNOS signaling pathways in the vasculature.
Determination of lidocaine based on electrocatalysis of a chemically modified electrode

The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin (Hb) immobilized on gold film modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA). According to the results of voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity and good electrocatalytic activity for the reduction of lidocaine, motivating us to construct drug biosensors. With this study, a new electroanalytical procedure is proposed for the determination of lidocaine level in medical applications or therapeutic formulations containing lidocaine as the active ingredient.
Scrub Typhus Reemergence in the Maldives

In summer 2002, an outbreak of febrile illness began in the Maldives in the Indian Ocean. Through April 2003, officials recorded 168 cases with 10 deaths. The Armed Forces Research Institute of Medicine in Bangkok confirmed Orientia tsutsugamushi and conducted a joint investigation with the Ministry of Health, Maldives. These cases of scrub typhus were the first in the Maldives since World War II.
Plasma kinetics of apoC-III and apoE in normolipidemic and hypertriglyceridemic subjects.

Apolipoprotein (apo) C-III and apoE play a central role in controlling the plasma metabolism of triglyceride-rich lipoproteins (TRL). We have investigated the plasma kinetics of total, very low density lipoprotein (VLDL) and high density lipoprotein (HDL) apoC-III and apoE in normolipidemic (NL) (n = 5), hypertriglyceridemic (HTG, n = 5), and Type III hyperlipoproteinemic (n = 2) individuals. Apolipoprotein kinetics were investigated using a primed constant (12 h) infusion of deuterium-labeled leucine. HTG and Type III patients had reduced rates of VLDL apoB-100 catabolism and no evidence of VLDL apoB-100 overproduction. Elevated (3- to 12-fold) total plasma and VLDL apoC-III levels in HTG and Type III patients, although associated with reduced apoC-III catabolism (i.e., increased residence times (RTs)), were mainly due to increased apoC-III production (plasma apoC-III transport rates (TRs, mean +/- SEM): (NL) 2.05 +/- 0.22 (HTG) 4.90 +/- 0.81 (P < 0.01), and (Type III) 8.78 mg. kg(-)(1). d(-)(1); VLDL apoC-III TRs: (NL) 1.35 +/- 0. 23 (HTG) 5.35 +/- 0.85 (P < 0.01), and (Type III) 7.40 mg. kg(-)(1). d(-)(1)). Elevated total plasma and VLDL apoE levels in HTG (2- and 6-fold, respectively) and in Type III (9- and 43-fold) patients were associated with increased VLDL apoE RTs (0.21 +/- 0.02, 0.46 +/- 0. 05 (P < 0.01), and 1.21 days, NL vs. HTG vs. Type III, respectively), as well as significantly increased apoE TRs (plasma: (NL) 2.94 +/- 0.78 (HTG) 5.80 +/- 0.59 (P < 0.01) and (Type III) 11.80 mg. kg(-)(1). d(-)(1); VLDL: (NL) 1.59 +/- 0.18 (HTG) 4.52 +/- 0.61 (P < 0.01) and (Type III) 11.95 mg. kg(-)(1). d(-)(1)). These results demonstrate that hypertriglyceridemic patients, having reduced VLDL apoB-100 catabolism (including patients with type III hyperlipoproteinemia) are characterized by overproduction of plasma and VLDL apoC-III and apoE.
The prothrombin 20210A allele influences clinical manifestations of hemophilia A in patients with intron 22 inversion and without inhibitors.

BACKGROUND AND OBJECTIVES The modulation of disease severity in hemophilia A (HA) patients may be related to the co-inheritance of mutations in genes with a known thrombotic effect such as factor V Leiden (FVL) and prothrombin. In the Spanish population, the prothrombin 20210A (PT20210A) allele is the most prevalent genetic risk factor for venous thromboembolism. DESIGN AND METHODS We investigated the presence of both mutations in a cohort of 265 hemophiliac patients divided into two groups: I) 140 unrelated patients with moderate and mild HA and II) 125 unrelated patients with severe HA (83 carrying an inversion of intron 22). RESULTS In group I, 4 patients had the FVL (2.8% vs. 2.98% controls) and 5 had the PT20210A (3.6% vs. 6.46% controls). In group II, two patients with inversion had the FVL (1.6%) and PT20210A was found in 10 patients (8%), five of them with inversion of intron 22 without inhibitors. One of these patients had the FVL and PT20210A mutations concomitantly. In the subgroup of patients with inversion who were carriers of the PT20210A, three parameters i.e. spontaneous bleeding (p=0.008), factor VIII utilization (p=0.016) and number of hemophilic arthropathies (p<0.0005) were significantly lower than in a subgroup of 11 age-matched non-PT20210A severe HA patients with inversion and without inhibitors. INTERPRETATION AND CONCLUSIONS These results indicate that the inheritance of PT20210A could be a protective factor that mitigates the clinical severity of HA.
Longitudinal brain metabolic characterization of chronic alcoholics with proton magnetic resonance spectroscopy.

BACKGROUND Proton magnetic resonance spectroscopy may elucidate the molecular underpinnings of alcoholism-associated brain shrinkage and the progression of alcohol dependence. METHODS Using proton magnetic resonance spectroscopy, we determined absolute concentrations of -acetylaspartate (NAA), creatine/phosphocreatine (Cr), and choline (Cho)-containing compounds and -inositol (mI) in the anterior superior cerebellar vermis and frontal lobe white matter in 31 alcoholics and 12 normal controls. All patients were examined within 3 to 5 days of their last drink. Patients who did not relapse were again studied after 3 weeks and 3 months of abstinence by using an on-line repositioning technique that allows reliable localization of volumes of interest (VOIs). RESULTS At 3 to 5 days after the last drink, frontal white matter metabolite concentrations were not significantly different from those of normal controls, whereas brain tissue in the VOI was reduced. Cerebellar [NAA] and [Cho] and brain and cerebellar volumes were decreased, but [Cr], [mI], and VOI brain tissue volume were not significantly different. Eight patients relapsed before 3 weeks (ER), 12 relapsed between 3 weeks and 3 months (LR), and 11 did not relapse (NR) during 3 months. Cerebellar [NAA] was reduced only in ER patients, despite the fact that ER patients drank for significantly fewer years and earlier in life than LR or NR patients. After 3 months, in the 11 continuously abstinent patients, cerebellar [NAA] and brain and cerebellar volumes increased; cerebellar [Cho], [Cr], and [mI] and VOI brain tissue did not change significantly. CONCLUSIONS Decreased [NAA] and [Cho] in cerebellar vermis indicate a unique sensitivity to alcohol-induced brain injury. Cerebellar [NAA] increased with abstinence, but reduced [Cho] persisted beyond 3 months. Further studies are needed to determine whether low cerebellar [NAA] is a risk factor for, or consequence of, malignant, early-onset alcoholism.