Miracle-dz/UniFAR-FTUs huggingface dataset:
Simultaneous Carcinomas of the Breast and Ovary: Utility of Pax-8, WT-1, and GATA3 for Distinguishing Independent Primary Tumors from Metastases

Breast carcinomas rarely metastasize to the ovary and are even more rarely present clinically as primary ovarian tumors. However, patients with breast cancer not infrequently develop independent primary ovarian carcinomas. In these cases, distinction between independent primaries and metastatic tumors is crucial. Several comparative immunohistochemical studies have been reported, but few included significant clinicopathologic data and none investigated cases of ovarian and breast carcinomas from the same patients. In this study, we compared 18 cases of patients with bona fide independent breast and ovarian carcinomas (15 high-grade serous and 3 clear cell carcinomas), with 9 cases of patients with known mammary carcinomas (7 lobular and 2 ductal carcinomas) metastatic to the ovary. Immunohistochemical stains for Pax-8, WT-1, and GATA3 were carried out on tissue microarrays (TMA). Most primary ovarian carcinomas were larger than the metastatic tumors (P=0.001) and were diagnosed at an advanced stage. All primary ovarian tumors showed marked nuclear pleomorphism, whereas only 2 metastatic breast carcinomas had Grade 3 nuclei (P=0.000). The vast majority of ovarian metastases (7/9) showed the typical pattern of lobular breast carcinoma. Pax-8 and WT-1 expression were found in 16 of 18 (88%) and 13 of 18 (72%) primary ovarian carcinomas, respectively. In contrast, all primary ovarian carcinomas were negative for GATA3. The 2 Pax-8-negative ovarian carcinomas were also negative for WT-1. With the exception of 3 triple-negative carcinomas, all primary breast carcinomas were positive for GATA3. All metastatic breast carcinomas were positive for GATA3 and negative for Pax-8. WT-1 expression was seen in only 1 of 9 metastatic breast carcinomas (11%). Patients with ovarian metastases had worse prognosis than patients with independent breast and ovarian carcinomas (P=0.000). Pax-8, WT-1, and GATA3 immunoreactions are useful in the distinction between independent primaries and metastatic mammary carcinomas to the ovary in the light of clinicopathologic findings.
Benefits of Probiotics in Oral cavity - A Detailed Review.

The development of resistance to a range of antibiotics by some important pathogens has raised the possibility of a return of humans to the pre-biotic dark ages. The time has come to shift the paradigm of treatment from specific bacteria elimination to altering the bacterial ecology by probiotics. In order to better understand the pathogenesis of various oral diseases, it is necessary to understand the role of the ecology and microbiology of the oral cavity. Thus, the concept of bacteriotherapy has been an emerging field in dentistry. Probiotics are dietary supplements containing potentially beneficial bacteria or yeasts and has been found beneficial to the host health. They help in stimulating health promoting flora and also suppressing pathogens which cause and spread diseases. In the medical field, probiotics are used mainly in support therapy for gastrointestinal diseases. Recently, probiotics are being used as a treatment for various oral diseases. The aim of this review is to examine potential mechanisms of probiotic bacteria in the oral cavity and summarize observed effects of probiotics with respect to oral health. The review focuses on probiotic lactobacilli and bifidobacteria genera that are most utilized in various probiotic products.
Learning word pairs and glossed sentences: the effects of a single context on vocabulary knowledge

Previous research investigating the effects of contextualized and decontextualized tasks on vocabulary learning has focused on whether or not learners were able to gain knowledge of meaning and form. To date, research has generated little evidence indicating that context facilitates vocabulary learning. Decontextualized tasks tend to be equally or more effective than contextualized tasks at promoting knowledge of meaning and form. However, aspects of knowledge that would seem more likely to be gained through learning from context have rarely been measured. The present study examined the effects of context on grammatical functions, syntagmatic association, paradigmatic association, orthography, and meaning and form. Japanese EFL students learned target words in word pairs and a single glossed sentence. To measure the effects of each task on vocabulary learning each target word was tested in 10 different ways. The results showed that there was no significant difference between the scores of subjects who met target words in a single glossed sentence and those who learned word pairs. This suggests that a single glossed sentence context may have little effect on vocabulary knowledge. The effects each task had on the different aspects of vocabulary knowledge are discussed in detail.
Why Nondocumented Residents Should Have Access to Kidney Transplantation: Arguments for Lifting the Federal Ban on Reimbursement

Current U.S. legislation restricts reimbursement for organ transplantation for nondocumented residents, which makes it difficult for many immigrants, including children, to access the transplants they need. In this article, we offer moral, economic, and legal reasons that nondocumented immigrants deserve the same access to kidney transplantation as do legal residents. We argue that the current reasoning for such a ban is based on unjustified fears and unsupported assumptions, which are not a solid basis for determining eligibility for lifesaving therapy for the neediest members of our society.
Attention-deficit disorder (attention-deficit/ hyperactivity disorder without hyperactivity): A neurobiologically and behaviorally distinct disorder from attention-deficit/hyperactivity disorder (with hyperactivity)

Most studies of attention-deficit/hyperactivity disorder (ADHD) have focused on the combined type and emphasized a core problem in response inhibition. It is proposed here that the core problem in the truly inattentive type of ADHD (not simply the subthreshold combined type) is in working memory. It is further proposed that laboratory measures, such as complex-span and dual-task dichotic listening tasks, can detect this. Children with the truly inattentive type of ADHD, rather than being distractible, may instead be easily bored, their problem being more in motivation (underarousal) than in inhibitory control. Much converging evidence points to a primary disturbance in the striatum (a frontal–striatal loop) in the combined type of ADHD. It is proposed here that the primary disturbance in truly inattentive-type ADHD (ADD) is in the cortex (a frontal–parietal loop). Finally, it is posited that these are not two different types of ADHD, but two different disorders with different cognitive and behavioral profiles, different patterns of comorbidities, different responses to medication, and different underlying neurobiologies.Preparation of this manuscript was supported by grants from NIDA (R01 DA19685-16A2) and the McDonnell Foundation (JSMF Grant 21002016). The author gratefully thanks Russ Barkley, Dante Cicchetti, Michael Posner, and Margaret Weiss for comments on an earlier draft of the manuscript. Of course, only the author bears responsibility for any errors in this paper.
Critical Comparison of 31 Commercially Available Digital Slide Systems in Pathology

Advances in new technologies for complete slide digitization in pathology have allowed the appearance of a wide spectrum of technologic solutions for whole-slide scanning, which have been classified into motorized microscopes and scanners. This article describes technical aspects of 31 different digital microscopy systems. The most relevant characteristics of the scanning devices are described, including the cameras used, the speed of digitization, and the image quality. Other aspects, such as the file format, the compression techniques, and the solutions for visualization of digital slides, (including diagnosis-aided tools) are also considered. Most of the systems evaluated allow a high-resolution digitization of the whole slide within about 1 hour using a ×40 objective. The image quality of the current virtual microscopy systems is suitable for clinical, educational, and research purposes. The efficient use of digital microscopy by means of image analysis systems can offer important benefits to pathology departments.
Acquisition sur corpus d'informations lexicales fondées sur la sémantique différentielle

Les lexiques semantiques sont des ressources indispensables pour permettre a de nombreuses applications de traitement automatique des langues (resume automatique, recherche d'information, traduction automatique, etc.) d'acceder au sens d'un texte. La question de la pertinence des informations presentes dans de tels lexiques est cruciale : le sens d'un mot comme navet, par exemple, varie considerablement selon que le texte etudie est consacre a la gastronomie ou a la cinematographie. Un moyen economique et linguistiquement motive de disposer de descriptions de sens de mots reellement pertinentes est d'« apprendre » celles-ci a partir de l'utilisation effective des mots dans un corpus, collection de textes representative d'un domaine d'expression. Nous proposons pour tenter de repondre a ce defi une methodologie d'acquisition automatique sur corpus d'informations lexicales semantiques en trois etapes, fondee sur les principes linguistiques de la Semantique interpretative de F. Rastier. Par analyse statistique et comparaison des modes d'emploi des mots, en utilisant des methodes classiques ou originales, nous parvenons tout d'abord a rapprocher des mots appartenant a un meme domaine (par exemple donnee, transfert, reseau pour les NTIC), puis des mots de sens similaires (donnee et information). Enfin, nous proposons une premiere methode permettant la mise au jour de nuances fines marquant des distinctions de sens entre mots proches (donnee est plus « concret » que information), ce qui constitue un resultat encore inedit en acquisition automatique d'informations lexicales semantiques.
Temporal and intensive factors in binaural lateralization of auditory transients.

The present experiment employed three experienced listeners. The primary purpose was to investigate the ability of the listener to detect a just noticeable shift from center of a dichotically produced auditory image. Thresholds were determined using a modification of Fechner's Method of Right and Wrong Cases. Thresholds were evaluated by means of an oscilloscope and camera. All combinations of a 600‐Hz and a 6000‐Hz tone and rise times of 10, 50, and 250 msec were used. Individual threshold plots are shown for each experimental condition. Tables are presented showing the intensity levels of the lead signal and the intensity differences between the two signals during the rise‐time portion of the signal complex for the various values employed. A frequency‐dependent relationship was indicated only for the 10‐msec rise‐time signal. It was also noted that time differences between equal intensity portions (of the two signals) are not constant throughout the rise time of the signals.
Let There Be Light And Darkness: Findings From a Prestudy Concerning Cycled Light in the Intensive Care Unit Environment

The present study reports findings concerning light in an intensive care unit setting presented from 3 aspects, giving a wide view. The first part is a systematic review of intervention studies concerning cycled light compared with dim light/noncycled light. The findings showed that cycled light may be beneficial to preterm infant health. Second, a lighting intervention in the intensive care unit is presented, comparing and assessing experience of this lighting environment with that of an ordinary room. Significant differences were shown in hedonic tone, favoring the intervention environment. In the third part, measured illuminance, luminance, and irradiance values achieved in the lighting intervention room and ordinary room lighting are reported.
Um Sistema Autoadaptável para Predição de Ataques DDoS Fundado na Teoria da Metaestabilidade

Os ataques de Negacao de Servico Distribuidos (Distributed Denial of Service - DDoS) crescem significativamente em volume, sofisticacao e impacto. Exemplos sao os ataques DDoS contra a empresa francesa OVN e o provedor de nomes DYN, os quais atingiram volumes ineditos de trafego malicioso. Em geral, esses ataques possuem comportamentos inesperados, desta forma sao detectados ou mitigados apenas quando se encontram em estagios avancados. Diferente de outros trabalhos, nos advogamos pelo prognostico precoce de ataques DDoS a fim de evitar custos e perdas provenientes do ataque. Este trabalho apresenta STARK, um sistema autoadaptativo de predicao de ataques DDoS, que identifica indicios do ataque na rede antes deste alcancar estagios avancados. Com base na teoria da metaestabilidade, STARK prove um aprendizado estatistico nao supervisionado e identifica a iminencia de ataques DDoS. A avaliacao do STARK segue uma abordagem orientada a tracos, em que tres bases de dados sao utilizadas. Como resultado, STARK demonstra predizer os ataques DDoS com minutos ou horas de antecedencia.
Development of a Web-services-based e-diagnostics framework

In recent years, the emerging Web-services technology has provided a new and excellent solution to the data integration among heterogeneous systems. In this paper, a Web-services-based e-diagnostics framework (WSDF) is proposed. It can achieve the automation of diagnostic processes and diagnostics-information integration for semiconductor equipment. First, the system framework and the system component model are designed. Then, the object-oriented analysis and design of system components are accomplished. In particular, for the purpose of code reuse, several common functions, such as SOAP communication, UDDI registration, security mechanism, data exchange mechanism, and local database access, are built into a generic component, called Web-service agent. By inheriting the Web-service agent, other system components can be constructed and have these common functions. In addition, a generic equipment object model, a unified authentication-service mechanism, and a safe network connection are also designed in the framework. WSDF is intended to support the e-diagnostics functions defined by International SEMATECH. It is believed that WSDF can be applied to construct e-diagnostics systems for semiconductor manufacturing industry.
Branchial Cysts in Two Amazon Parrots (Amazona species)

Abstract A 37-year-old yellow-crowned Amazon parrot (Amazona ochrocephala) and a 20-year-old red-lored Amazon parrot (Amazona autumnalis) each presented with a large mass localized on the lateral neck. With the first bird, there was no evidence of signs of pain or discomfort, and the bird prehended and swallowed food normally. The second bird showed signs of mild upper-gastrointestinal discomfort. Results of an ultrasound examination and aspiration of the mass on each bird revealed a cystic structure. A computed tomography performed on the second bird revealed a large polycystic mass connected to the pharynx by a lateral tract. During surgical resection, both masses were found to originate from the subpharyngeal area. Based on topography and the histopathologic and immunohistochemical results, the masses were determined to be a second branchial cleft cyst for the first case and a second branchial pouch cyst for the second case. In addition, a carcinoma was present in situ within the epithelium of case 1, and the cyst in case 2 was secondarily infected. Branchial cysts are uncommonly diagnosed in veterinary and human medicine. These 2 cases are the first documented in parrots and appear similar to second branchial cysts reported in adult humans.
USS Monitor: A Monitoring System for Collaborative Ubiquitous Computing Environment

This paper introduces a monitoring system, USS monitor for a collaborative ubiquitous computing environment where the applications collaborate to achieve a service goal. We design USS monitor concerning the visualization of the collaboration and the variability of the applications in the main. The monitoring system includes the mechanisms to collect and visualize the state of the member applications for collaboration as well as the resource state of the machines. In addition, concerning the variability of the applications in the ubiquitous computing environment, we design an interaction protocol and the scalable message format between the monitor and the monitored entities. USS monitor is a set of processes and implemented using Java and C. It is operating in the testbed for collaborative ubiquitous computing environment.
Silicon Carbide-Based Remote Wireless Optical Pressure Sensor

Proposed is a silicon carbide (SiC) weak-lensing-effect-based wireless optical sensor that allows safe, repeatable, and accurate pressure measurement suitable for harsh environments. This completely passive front-end sensor design uses a remoted free-space optical beam that targets a single crystal SiC chip fitted as an optical window within a pressure capsule. With increasing differential capsule pressure, the SiC chip forms a weak convex mirror with a changing focal length. By monitoring the chip reflected light beam magnification, pressure in the capsule is determined. Using a 633-nm wavelength laser beam, the proposed sensor is experimentally tested at room temperature for 0- to 600-psi (0-41atm) differential pressures and a remoting distance of 2.5 m
Data acquisition technology of link layer filtering under Linux environment

This article first describes the architecture of Linux network stack, the principles of link layer's filtering acquisition, and then analyze the network card drivers, lastly, gives the building Scheme of data acquisition environment and the implementation strategies of link layer filtering acquisition. Using the data acquisition system to which the filter policy is added, reduces the packet loss rate, saved the system resources, and enhanced the processing efficiency.
Targeted delivery of antisense DNA in woodchuck hepatitis virus‐infected woodchucks

Summary. An asialoglycoprotein‐based DNA delivery system containing an antisense oligo DNA against the polyadenylation region and adjacent upstream sequences of woodchuck hepatitis virus (WHV) was prepared. Experimental woodchucks were inoculated neonatally with the woodchuck virus 23 weeks before initiating the study, and all animals subsequently developed hepatitis as evidenced by the presence of measurable levels of circulating viral DNA. Animals were injected intravenously (i.v.) with asialoorosomucoid (AsOR)‐poly‐l‐lysine complexes containing 0.1 mg kg‐1 antisense DNA for five consecutive days. Levels of surface antigen did not differ substantially between treated and control animals. However, intravenous administration of complexed antisense DNA significantly decreased viraemia, as shown by a five‐to 10‐fold decrease in circulating viral DNA 25 days post treatment. The decline lasted for at least 2 weeks, after which there was a gradual increase in DNA levels. Antisense DNA alone or a complex containing a random oligo DNA of the same size and linkage failed to have any significant effect on viral DNA levels. We conclude that antisense oligo DNA can be targeted to the liver in vivo, resulting in a substantial and prolonged decrease in viral DNA levels in WHV‐infected woodchucks.
Blood-brain barrier to hydrogen ion during acute metabolic acidosis in piglets.

The present study investigates the integrity of the blood-brain barrier to H+ or HCO3- during acute plasma acidosis in 35 newborn piglets anesthetized with pentobarbital sodium. Cerebrospinal fluid acid-base balance, cerebral blood flow (CBF), and cerebral oxygenation were measured after infusion of HCl (0.6 N, 0.191-0.388 ml/min) for a period of 1 h at a constant arterial PCO2 of 35-40 Torr. HCl infusion resulted in decreased arterial pH from 7.38 +/- 0.01 to 7.00 +/- 0.02 (P less than 0.01). CBF measured by the tracer microsphere technique was decreased by 12% from 69 +/- 6 to 61 +/- 4 ml.min-1.100 g-1 (P less than 0.05). Infusion of 0.6 N NaCl as a hypertonic control had no effect on CBF. Cerebral metabolic rate for O2 and O2 extraction was not significantly changed from control (3.83 +/- 0.20 ml.min-1.100 g-1 and 5.7 +/- 0.6 ml/100 ml, respectively) during acid infusion. Cerebral venous PO2 was increased from 41.6 +/- 2.1 to 53.8 +/- 4.0 Torr by HCl infusion (P less than 0.02) associated with a shift in O2-hemoglobin affinity of blood in vivo from 38 +/- 2 to 50 +/- 1 Torr. Cisternal cerebrospinal fluid pH decreased from 7.336 +/- 0.014 to 7.226 +/- 0.027 (P less than 0.005), but cerebrospinal fluid HCO3- concentration was not changed from control (25.4 +/- 1.0 meq/l). These data suggest that there is a functional blood-brain barrier in newborn piglets, that is relatively impermeable to HCO3- or H+ and maintains cerebral perivascular pH constant in the face of acute severe arterial acidosis. (ABSTRACT TRUNCATED AT 250 WORDS)
Desarrollo de algoritmos para la estructuración dinámica de información y su aplicación a la detección de sucesos

La motivacion fundamental de esta tesis es el problema de la deteccion de topicos, cuyo objetivo es identificar en un flujo continuo de noticias, aquellas que pertenecen a un nuevo topico o a uno conocido previamente. En el trabajo se presenta un sistema de deteccion de topicos en linea, denominado JERARTOP, que va mas alla de un sistema tradicional de deteccion, ya que permite identificar no solo los topicos presentes en un flujo de noticias sino tambien los posibles sucesos mas pequenos que ellos comprenden. Este sistema clasifica, ademas, en un conjunto de tematicas pre-definidas a cada topico detectado y proporciona un resumen de los contenidos asociados en cada uno de ellos. Con este fin, se proponen tres nuevos algoritmos de agrupamiento incrementales: Compacto Incremental, Fuertemente Compacto Incremental y Jerarquico Incremental que construyen grupos disjuntos, solapados y jerarquias de grupos respectivamente. Estos algoritmos permiten la manipulacion de objetos mezclados, no imponen restricciones a la funcion de semejanza ni a la forma de los grupos y son independientes del orden de presentacion de los objetos. Ademas se propone un metodo de construccion automatica de resumenes a partir de una particion de conjuntos de documentos. Nuestro metodo emplea el calculo de los testores tipicos como su operacion primaria y, a partir de ellos, construye el resumen de cada grupo.
Interactions between predator- and diet-induced phenotypic changes in body shape of crucian carp

Predator cues and diet, when studied separately, have been shown to affect body shape of organisms. Previous studies show that the morphological responses to predator absence/presence and diet may be similar, and hence could confound the interpretation of the causes of morphological differences found between groups of individuals. In this study, we simultaneously examined the effect of these two factors on body shape and performance in crucian carp in a laboratory experiment. Crucian carp (Carassius carassius) developed a shallow body shape when feeding on zooplankton prey and a deep body shape when feeding on benthic chironomids. In addition, the presence of chemical cues from a pike predator affected body shape, where a shallow body shape was developed in the absence of pike and a deep body shape was developed in the presence of pike. Foraging activity was low in the presence of pike cues and when chironomids were given as prey. Our results thereby suggest that the change in body shape could be indirectly mediated through differences in foraging activity. Finally, the induced body shape changes affected the foraging efficiency, where crucians raised on a zooplankton diet or in the absence of pike cues had a higher foraging success on zooplankton compared to crucian raised on a chironomid diet or in the presence of pike. These results suggest that body changes in response to predators can be associated with a cost, in terms of competition for resources.