Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of the Roles and the Dynamics of Breathy and Whispery Voice Qualities in Dialogue Speech

Breathy and whispery voices are nonmodal phonations produced by an air escape through the glottis and may carry important linguistic or paralinguistic information (intentions, attitudes, and emotions), depending on the language. Analyses on spontaneous dialogue speech utterances of several speakers show that breathy and whispery voices are related with the expression of a variety of emotion- or attitude-related paralinguistic information. Potential acoustic parameters for characterizing breathy/whispery segments are introduced and used to describe the dynamics of breathiness along the utterances in different paralinguistic items.
Sense Structure in Cube: Lexical Semantic Representation in Chinese Wordnet

The representation of lexical semantic knowledge has been one of the most important research topics in the field of computational lexical semantics. Among relevant lexical resources, the design architecture of Princeton WordNet is the most popular one. In this paper, however, we argue that the current synset scheme requires more extensions when applied to the analysis of deeper sense structure in Chinese Wordnet. Issues involved include the underlying structure of sense, meaning facet and their relations. Based on a large amount of empirical analysis of sense data, this paper proposes a fine-grained framework in representing lexical semantic knowledge for Chinese Wordnet, which we believe will be an important consideration for the envisioned cross-lingual global wordnet grid construction. The systematic polysemy patterns found among meaning facets can also be used as a human gold standard of hand-annotated data for metonymy resolution task.
Semg-based posture recognition of elbow flexion and extension

Surface electromyographic signal (sEMG) is used in some fields such as human machine interaction and measurement of human motor function, because it can reflect the activation of human muscle. Though the recognition of motion pattern of human limbs has been researched for many years, continuous recognition for human elbow motion without load is still difficult because of low signal noise ratio (SNR). In this paper, we proposed an improved weighted peaks method to process the filtered sEMG signals from the biceps muscle and adapted linear fitting method to obtain the elbow motion in sagittal plane. The experiments showed the proposed method can effectively process the sEMG signals and obtain the activation of biceps muscle. The experimental results show the similar data of elbow motion compared to the data derived from an inertia sensor.
Reputation and Opportunism in the Process of IPO Under-Pricing

Purpose - The purpose of this paper is to empirically analyze the underwriter reputation effect on IPO issue price efficiency in China growth enterprise market based on information asymmetry theory, with using the residual income valuation mode to control IPO companies’ intrinsic value influence.Design/Methodology/Approach - Using empirical research method, this paper design four empirical models to test the relationships between the underwriter reputation and the issue price and the degree of under-pricing and the underwriter fees and the over-raise funds.Findings - By analyzing the data of China growth enterprise market, it is founded that in the context of China security market efficiency being not high, imperfect reputation mechanism can’t constrain underwriter’s opportunism behavior leading to third-party authentication function weakened. IPO issue price in China growth enterprise market deviates from intrinsic value and underwriters can’t reduce information asymmetry level between issuers and investors. Underwriter’s opportunism behavior makes underwriters and issuers interests become convergence. In the condition of issue price and under-pricing having no significant relationships, combined with underwriter’s opportunism behavior to take the high offer strategy striving for allotment shares is inquiry investors’ dominant choice.Practical implications - The conclusion could provide a reference for the regulatory authorities to promote the reputation system and advance information transmission efficiency and establish punishment regime through ensuring that underwriters play effective third-party authentication.Originality/value - This paper empirically analyzes and veriﬁes, for the ﬁrst time, the relationship between the underwriter reputation and the issue price and the degree of under-pricing and the underwriter fees and the over-raise funds. Using the residual income valuation mode to control IPO companies’ intrinsic value influence and the research of the relationship between the underwriter reputation and the underwriter behavior is a pioneering in China.
Analysis of the active conformation of angiotensin II: a comparison of AII and non-peptide AII antagonists.

Several molecular models of angiotensin II (AII) were constructed using information derived primarily from conformationally constrained AII analogues. In order to refine the original models, AII was compared using computer-aided molecular graphics with several of the recently reported non-peptide AII antagonists. As a first approximation, the imidazole, phenyl ring and acidic moiety (i.e., carboxyl, tetrazole) of the non-peptide AII antagonists were overlapped with the corresponding features of the peptide. AII and Dup 753 were overlapped using Multifit (SYBYL) and then both were optimized individually and refit; this procedure was repeated three times to generate a working model of AII. The less-potent non-peptide AII antagonists S 8308 and Exp 6155 could also be overlaid with the model of AII, albeit not as well as DuP 753. The working model of AII, which has a twisted U-shape, places the imidazole of His6 and the terminal carboxylate approximately 8.7 A apart.
Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

Nonalcoholic fatty liver disease is increasing in prevalence. It can be subdivided into nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Five to twenty percent of cases progress from NAFL to NASH. Increased hepatic Th17 cells and IL-17 expression were observed in NASH mice and patients, respectively. We analyzed CD4+ effector T cells and regulatory T cells (Tregs) from peripheral blood and livers of NAFL and NASH patients. A total of 51 NAFL patients, 30 NASH patients, 31 nonalcoholic fatty liver disease patients (without histology), and 43 healthy controls were included. FACS analysis was performed on PBMCs and intrahepatic lymphocytes. Compared with healthy controls, a lower frequency of resting Tregs (rTregs; CD4+CD45RA+CD25++) and higher frequencies of IFN-γ+ and/or IL-4+ cells were detected among CD4+ T cells of peripheral blood in NASH, and to a lesser degree in NAFL. In hepatic tissue, NAFL to NASH progression was marked by an increase in IL-17+ cells among intrahepatic CD4+ T cells. To define immunological parameters in peripheral blood to distinguish NAFL from NASH, we calculated different ratios. Th17/rTreg and Th2/rTreg ratios were significantly increased in NASH versus NAFL. The relevance of our findings for NASH pathogenesis was highlighted by the normalization of all of the changes 1 y after bariatric surgery. In conclusion, our data indicate that NAFL patients show changes in their immune cell profile compared with healthy controls. NAFL to NASH progression is marked by an increased frequency of IL-17+ cells among intrahepatic CD4+ T cells and higher Th17/rTreg and Th2/rTreg ratios in peripheral blood.
Predictors of Parental Mediation Regarding Children's Smartphone Use

Children's addiction to smartphones has become a serious issue, and parental mediation could help prevent children's problematic use of smartphones. This research examined the factors that predict and explain parents' intention to mediate children's behavior over smartphone use. Based on a survey of 460 parents of elementary school students, we found that parental mediation was predicted by (a) parent's own addiction to smartphones, (b) perceived severity of smartphone addiction, and (c) personality traits such as neuroticism, openness, and agreeableness. To the best of our knowledge, this study is the first to examine the predictors of parental mediation regarding children's smartphone addiction, and the findings suggest some strategies to increase parental mediation.
Evidence for a Role of VIPP1 in the Structural Organization of the Photosynthetic Apparatus in Chlamydomonas[W][OA]

This work shows that suppressing the expression of the vesicle-inducing protein in plastids (VIPP1) in Chlamydomonas leads to aberrant structures at the origin of thylakoids and to structural defects particularly in photosystem II that render mutants sensitive to high light. The data indicate that VIPPs act in the biogenesis of thylakoid membrane core complexes, in particular the photosystems. The vesicle-inducing protein in plastids (VIPP1) was suggested to play a role in thylakoid membrane formation via membrane vesicles. As this functional assignment is under debate, we investigated the function of VIPP1 in Chlamydomonas reinhardtii. Using immunofluorescence, we localized VIPP1 to distinct spots within the chloroplast. In VIPP1-RNA interference/artificial microRNA cells, we consistently observed aberrant, prolamellar body-like structures at the origin of multiple thylakoid membrane layers, which appear to coincide with the immunofluorescent VIPP1 spots and suggest a defect in thylakoid membrane biogenesis. Accordingly, using quantitative shotgun proteomics, we found that unstressed vipp1 mutant cells accumulate 14 to 20% less photosystems, cytochrome b6f complex, and ATP synthase but 30% more light-harvesting complex II than control cells, while complex assembly, thylakoid membrane ultrastructure, and bulk lipid composition appeared unaltered. Photosystems in vipp1 mutants are sensitive to high light, which coincides with a lowered midpoint potential of the QA/QA− redox couple and increased thermosensitivity of photosystem II (PSII), suggesting structural defects in PSII. Moreover, swollen thylakoids, despite reduced membrane energization, in vipp1 mutants grown on ammonium suggest defects in the supermolecular organization of thylakoid membrane complexes. Overall, our data suggest a role of VIPP1 in the biogenesis/assembly of thylakoid membrane core complexes, most likely by supplying structural lipids.
Long-term treatment of trigeminal neuralgia with carbamazepine.

The results of treating 143 patients with trigeminal neuralgia with carbamazepine (CBZ) over a 16-year period have been reviewed. The drug was effective initially with few mild side effects in 99 patients (69%). Of these, 19 developed resistance later, i.e. between 2 months and 10 years after commencing treatment, and required alternative measures. Of the remaining 80 (56%), the drug was effective in 49 for 1-4 years and in 31 for 5-16 years. Thirty-six patients (25%) failed to respond to CBZ initially and required alternative measures, as did 8 (6%) who were intolerant of the drug. One patient developed CBZ-induced water intoxication with hyponatraemia. Subsequently hyponatraemia was excluded in 17 patients who had been taking CBZ for between 4 months and 7 years. This study has thus confirmed the efficacy of CBZ in the treatment of trigeminal neuralgia and shown that it may continue to be effective for many years.
“We know it when we see it” is not good enough: toward a standard definition of plagiarism that transcends theft, fraud, and copyright

Many of the assumptions that inform the ways we respond to issues of plagiarism are based in laws and traditions that pertain to stealing or to copyright. Laws about stealing, however, assume key concepts that are at odds with the conceptual realities of plagiarism. The notion of taking something, for instance, carries with it the concomitant idea that the rightful owner is deprived of the use of that thing. Laws about copyright are similarly derived from the notion of a physical text being duplicated to make additional (physical) copies to be sold, implying that if copyright is violated, the rightful owner suffers (financial) harm. Neither set of laws appropriately addresses plagiarism, however, which can occur without depriving the author/owner of the work or the right to profit from it. This paper will differentiate the elements of plagiarism from those of theft and copyright violations, and attempt to define plagiarism in terms that accurately describe its essential elements. Key Ideas • Plagiarism does not = theft. It is not the same as "taking. " • Plagiarism does not = copyright violation. It does not necessarily deprive the owner of his/her rights. • Plagiarism needs its own set of elements (similar to the elements of a crime). Discussion Question 1 What are the essential elements of plagiarism? Discussion Question 2 If we define plagiarism strictly, do we also need to come up with a new vocabulary to describe other things that currently seem to fall, by default, under the heading of plagiarism (such as "self plagiarism")?
The effects of delayed insemination on fertilization and early cleavage in the pig.

group. The conception rate fell from 100% in the control group to 66\m=. \7% in Group 6, whereas the incidence of unilateral fertilization increased from 8\m=. \3%in the controls to 33% in Group 6. Within the seventy-two animals with some penetrated eggs, the mean percentage of unfertilized eggs increased from 1\m=. \3%(Group 2) to 23\m=. \9%(Group 6), but unfertilized eggs occurred principally as a result of unilateral fertilization. No decrease in the mean proportion of fertilized eggs developing normally was found until the eggs were 12 hr old at penetration (Group 4), when the figure fell to 73\m=. \6%. A further decrease occurred in Groups 5 and 6, means of 55\m=. \4%and 66\m=. \9%respectively, being obtained. The
A novel assay reveals the blockade of esterases by piperonyl butoxide.

BACKGROUND Conventional in vitro assays sometimes fail to reveal esterase inhibition by piperonyl butoxide (PBO), although synergism studies suggest loss of esterase-mediated sequestration of insecticide does take place. A new in vitro assay has been devised that routinely reveals binding between PBO and these esterases. RESULTS The new 'esterase interference' assay detects the blockade of resistance-associated esterases in a species, Myzus persicae Sülzer, where this has not previously been seen. The assay also demonstrates directly the protective effect esterases may confer to target sites of insecticides. CONCLUSION The new assay reveals esterase blockade by PBO and thus has the potential to be used as a high-throughput screening method for other potential synergists.
Analysis of p53 and bcl‐2 protein expression in the non‐tumorigenic, pretumorigenic, and tumorigenic keratinocytic hyperproliferative lesions

Background: The hyperproliferative keratinocytic lesions encompass a wide range of non‐tumorigenic, pretumorigenic, and tumorigenic conditions. The aim of this work was to examine the expression patterns of apoptosis‐linked molecules (bcl‐2 and p53) in these lesions.
Cytomorphometry as a Diagnostic Tool for Assessing the Altered Nature of Exfoliated Buccal Mucosal Cells in Diabetic and Hypertensive Patients.

Aim: To study the cytomorphometric analysis of cells in the cytologic smears from buccal mucosal cells of diabetic and hypertensive patients. Materials and Methods: Smears were collected from clinically normal mucosa of 30 diabetes and 30 hypertensive patients and 30 healthy controls. Smears were stained using papanicolauo method. Cell diameter, nuclear diameter, cell area, nuclear area and nuclear: cytoplasmic ratio was obtained for each patient.Results: Compared to normal it was found that there were significant changes in diameter of cells (P<0.01), nucleus diameter (P<0.01), cell area(P<0.01) and nuclear area (P<0.001) in diabetes patients but not in hypertensive patients (P>0.01). Conclusion: Diabetes produces definite cytomorphometric changes in buccal mucosal cells. This research area is worthy for further exploration for public health implications.
Managerial Discipline and Firm Responses to a Decline in Operating Performance

This study documents the operational and financial responses of UK companies that experienced a large decline in operating performance between 1992 and 1998. We present evidence showing that firms downsized by selling divisions, withdrawing from lines of business, reducing employment levels, and, in some cases, expanding, in response to the performance shock. Higher leverage, and in particular short-term leverage, increased the likelihood of downsizing. Whilst there is no evidence that board structure plays an important role in firm responses, external control threats appear to increase the likelihood of downsizing, forced CEO turnover, and rates of director removals and appointments. Issues of new equity play a role in board restructuring but also provide more funds for managers to expand their operations. Finally, sample matching techniques provide limited evidence of increases in operating performance following various corporate restructuring actions.
Musculoskeletal injuries among Malaysian badminton players.

INTRODUCTION The purpose of this study was to investigate the pattern of musculoskeletal injuries sustained by Malaysian badminton players. METHODS This is a retrospective case notes review of all badminton players who attended the National Sports Institute (NSI) Clinic, Kuala Lumpur, Malaysia, and were diagnosed with musculoskeletal injuries. RESULT In a two and a half year period, from January 2005 to June 2007, 469 musculoskeletal injuries were diagnosed among badminton players at the NSI Clinic. The mean age of the players who attended the clinic was 19.2 (range 13-52) years. Approximately 60 percent of the injuries occurred in players younger than 20 years of age. The majority of injuries (91.5 percent) were categorised as mild overuse injury and mostly involved the knee. CONCLUSION The majority of the injuries sustained by badminton players in this study were due to overuse, primarily in the knee. The majority of the injuries were diagnosed in younger players and occurred during training/practice sessions. There was no difference in terms of incidence and types of injuries between the genders.
Clinical Features and Haematological Indices of Neonatal Septicaemia in Poor Resource Setting

Background: The burden of neonatal septicaemia has remained high worldwide and even more severe in the developing countries like ours. Clinical manifestation is variable and non-specific thereby resulting in delay in diagnosis. Blood culture which is the gold standard for diagnosis of neonatal septicaemia (NNS) has many drawbacks due to long waiting time for culture process, low yield, improper inoculation adding to the problem of late diagnosis. Haematological parameters have been utilized in rapid and early diagnosis of NNS and prompt treatment thus circumventing problems associated with drawbacks in blood culture. Objective: The study was to identify the common clinical features of neonatal septicaemia and haematological indices that were commonly utilized in rapid diagnosis of NNS, and also to determine their sensitivity, specificity, positive predictive and negative predictive value. Materials and Methods: The study was prospective and neonates that had clinical features suggestive of neonatal septicaemia were enrolled consecutively into the study. The patients were appropriately investigated including blood cultures, CSF cultures and urine among others, also blood sample for packed cell volume (PCV), total white cell count (TWBC), absolute neutrophil count (ANC), absolute platelet count (APC). Immature to mature neutrophil ratio (I/MNR), immature to total neutrophil ratio (I/TNR) and micro-ESR (erythrocyte sedimentation rate) was also done and analyzed. Results: The common clinical symptoms were fever 39.5%, poor feeding 33.6%, excessive cry 38.7%, difficulty in breathing 50.0%, yellowish skin 26.9%, while the common physical signs were hyper/hypothermia 41.1%, tachypnoea 41.2%, septic umbilical stump 64.0%, hepatomegally 37.3% and convulsions 42.0%. Blood culture yield was positive in 41.82% and mortality was as high as 28.00%, the incidence of NNS was 5.9/1000 live births. The haematological parameters as marker of NNS PCV, TWBC, ANC, APC, I/MNR, I/TNR and micro-ESR individually were statistically significant (P < 0.05), also their individual sensitivity, specificity, positive and negative predictive values were highly associated with neonatal septicaemia. However, when they were tested in combinations these markers of neonatal septicaemia had low sensitivity, specificity and their predictive values were weak in excluding NNS. Conclusions: The need for early and rapid diagnosis of NNS is pertinent, culturing of the appropriate specimens remains the only way to identify the aetiological organisms, but is associated with delay. Haematological indices are excellent markers of NNS and analysis is rapid and can easily be done in our laboratory settings, and when utilized efficiently, it would circumvent the delay associated with blood culture for long waiting period for the result, thereby reducing morbidity and mortality.
Quantitative measurement of oil droplets using compressive digital holography

Compressive holography is applied to characterize the oil droplet in oil spill experiment. The compressive reconstruction method demonstrates good performance in the real experimental data compared with traditional back-propagation based method. The phase transition curve in simulation illustrates the effects of sparsity of object function on the compressive reconstruction success rate, which indicates the effectiveness of free space propagation as a signal mixer in compressive measurement.
CLOUD COMPUTING APPROACH FOR IT COST REDUCING IN INDONESIA GOVERNMENT‘S E-PROCUREMENT SYSTEM : Case Study Jawa Barat e-Procurement System Unit (LPSE Jabar Indonesia )

The development of “eSomething” takes place in almost all government sector, include Indonesia Government. One of electronic based system developed recently in Indonesia is e-procurement system. This condition bring much higher financial requirement and qualified Ihuman resources to build the IT infrastructure. We proposed cloud computing scheme architecture for eprocurement system in Indonesia (Jawa Barat) to reduc the IT cost for implementing the e-procurement system. The ROI analysis is carried out to select which cloud scheme is best to apply in Indonesia condition. We also propose the architecture of the new cloud based system based on the analysis conducted. The analysis result show that a significant cost reducing is achieved by implementing Infrastructure as a Service scheme cloud computing in e-procurement system at Jawa Barat Indonesia. Keywords-cloud computing, e-procurement, IaaS