Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease

Background: There is evidence that adipocytokines play an important role in metabolism and in inflammation. Because human metabolism dramatically changes in inflammatory bowel disease (IBD) and chronic inflammation is the hallmark of the disease, we studied serum levels of leptin, adiponectin, resistin, and ghrelin in patients with ulcerative colitis (UC) and Crohn's disease (CD) in comparison with healthy controls (HC). Methods: Leptin, adiponectin, resistin, and active ghrelin serum levels were measured in 100 IBD patients (46 UC and 54 CD) and in 60 matched HC using commercially available enzyme‐linked immunosorbent assays. Leptin, adiponectin, resistin, and ghrelin levels were correlated with disease activity, type, localization, and treatment. Results: Mean serum leptin levels were 10.6 ± 2.0 ng/mL in UC patients, 12.5 ± 2.6 ng/mL in CD patients, and 15.0 ± 1.8 ng/mL in HC (P = .01). Mean serum adiponectin levels were 9514.8 ± 787.8 ng/mL in UC patients, 7651.1 ± 613 ng/mL in CD patients, and 7270.6 ± 559.4 ng/mL in HC (P = .05). Mean serum resistin levels were 21.2 ± 2.2 ng/mL in UC patients, 18.7 ± 1.6 ng/mL in CD patients and 11.8 ± 0.6 ng/mL in HC (P = .0002). Mean serum ghrelin levels were 48.2 ± 4.2 pg/mL in UC patients, 49.4 ± 4.6 pg/mL in CD patients and 14.8 ± 3.0 pg/mL in HC (P < .0001). Serum levels of these adipocytokines were not correlated with either C‐reactive protein levels or the clinical indices of activity. No association between serum adipocytokines levels and disease localization in both UC and CD patients was found. Only serum ghrelin was significantly higher in ileal compared with colonic CD (P = .04). Conclusions: Serum levels of adiponectin, resistin, and active ghrelin are increased whereas serum levels of leptin are decreased in patients with IBD. Further studies are needed to elucidate the role of adipocytokines in IBD.
Use of hyphomycetous fungi for managing insect pests.

1Department of Entomology and Plant Pathology, Mississippi State University, Mississippi State, MS 39762, USA; 2Lethbridge Research Centre, Agriculture and Agri-Food Canada, PO Box 3000, Lethbridge, Alberta T1J 4B1, Canada; 3School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK; 4Institute of Microbiology, LeopoldFranzens University Innsbruck, Technikerstrasse 25, A-6020 Innsbruck, Austria
Down-regulated MYH 11 Expression Correlates with Poor Prognosis in Stage II and III Colorectal Cancer

Colorectal cancer (CRC) is responsible for more than 500, 000 deaths worldwide every year. Stage II and III tumors together represent approximately 70% of CRC patients. Multidisciplinary treatments induce clinical remission in about 60% of stage II and III cases. However, 40% to 50% of patients will relapse, and most of them will die from secondary diseases (Cserni, 2003; de Gramont et al., 2007). Tumor stage by American Joint Committee on Cancer (AJCC) (Compton et al., 2000) and differentiation are the main prognostic factors used in clinical practice. However, they are not sufficient to evaluate the likelihood of survival. Therefore, biomarkers are urgently needed to predict prognosis and facilitate treatment (Ding et al., 2012; Fang et al., 2012; Lu et al., 2012; Deng et al., 2013; Hu et al., 2013; Li et al., 2013). Myosin-11 is a protein that in humans is encoded by the MYH11 gene (Matsuoka et al., 1993). It is a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. Recently, some researches have shown that myosin has many intracellular functions, including cell migration and adhesion, intracellular transport, locating of organelles and macromolecules and signal transduction and tumor suppression, which indicate that Myosin-11 is more
How sleep and mental disorders are related to complaints of daytime sleepiness.

BACKGROUND Daytime sleepiness is widespread and has negative impacts on the public sector. OBJECTIVE To ascertain the incidence and prevalence of daytime sleepiness and associated risk factors in the general population. METHOD In 1994, a representative sample of the non-institutionalized British population aged 15 years or older was interviewed via telephone using an expert computer-assisted program designed to facilitate surveys of this type (Sleep-Eval, M. M. Ohayon, Montreal, Quebec). Subjects were classified into 3 groups based on the severity of their daytime sleepiness. We completed 4972 interviews (acceptance rate, 79.6%). RESULTS Severe daytime sleepiness was reported in 5.5% (95% confidence interval, 4.9%-6.1%) of the sample, and moderate daytime sleepiness in another 15.2% (95% confidence interval, 14.2%-16.2%). Associated factors with severe daytime sleepiness included female sex, middle age, napping, insomnia symptoms, high daily caffeine consumption, breathing pauses or leg pain in sleep, depressive disorder (based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria), falling asleep while reading or watching television, and motor vehicle crashes or accidents involving use of machinery. Moderate daytime sleepiness was associated with female sex, napping, insomnia symptoms, arthritis or heart disease, and gross motor movements during sleep. CONCLUSIONS It is likely that daytime sleepiness deleteriously affects work activities, social and/or marital life, and exhibits a negative socioeconomic impact. In addition, the risk of a motor vehicle crash appears to be higher in this specific population: twice as many subjects operating a motor vehicle or using machine tools reported having a crash or accident, respectively, in the previous year in the groups with severe daytime sleepiness or moderate daytime sleepiness than did the general population with no daytime sleepiness. The high prevalence rates of daytime sleepiness and multiplicity of related factors mandate further scrutiny by public health officials.
Generative processing and false memories: when there is no cost.

Encoding manipulations (e.g., levels of processing) that facilitate retention often result in greater numbers of false memories, a pattern referred to as the more is less effect (M. P. Toglia, J. S. Neuschatz, & K. A. Goodwin, 1999). The present experiments explored false memories under generative processing. In Experiments 1-3, using Deese-Roediger-McDermott (DRM) lists with items that were either read or generated, the authors found recognition and recall tests indicated generation effects for true memories but no increases in false memories (i.e., generation at no cost). In Experiment 4, in a departure from the DRM methodology, a cuing procedure resulted in a more is less pattern for congruous generation,and a no cost pattern for incongruous generation. This highlights the critical distinction between these encoding contexts.
Improving patient's independence and treating depressive symptoms can promote physical activity in diabetic patients.

W e would like to thank Dr. Dinc for the interest in our article suggesting that increasing patient independence and treating depressive symptoms can promote physical activity in type 2 diabetes mellitus patients. Initially, Dr. Dinc and cols. have reaffirmed that community-based studies are highly important. This particular study evaluated diabetic patients from a tertiary care center. We agree that it is important to use scales that have been validated and largely, used as it was done in our study (1). Also, despite the number of controls, data analysis was adequate; however, a greater number of patients and of controls would increase the power of our data. At present, we did not include metabolic status of the patients because this was mainly an analysis of physical activity status, comorbidities, depressive symptoms, and health-related quality of life. We considered that our results, showing a high number of diabetic patients performing physical activity, are valuable because they prove that educational programs are effective. Nevertheless, we know that a lot more needs to be done in order to achieve prevention of metabolic syndrome and diabetes. In this population, heart failure was not reported and myocardial ischemia and/or previous myocardial infarct were found in 39 (20%) of the cases. As described, these comorbidities were unrelated with physical activity (2). Of note, even low-intensity physical activity has been shown to improve health related measures, particularly cardiovascular function (3). Thus, after safeguarding patients with cardiovascular disorders, advising patients to perform physical activity seems warranted, as a general rule. We think that the need to classify patients according to their cardiac status in order to encourage occasional low-level physical activity could inhibit the encouragement of exercise practice. Of course, physical abilities and comorbidities must be considered for a safe implementation of exercises, and individuals with any indication of cardiovascular disease should be thoroughly evaluated. Recently, a study has shown that a universal strategy to promote physical activity in primary care has the potential to increase the number of years lived free from physical disease (4). The same study affirms that there is only weak evidence that this strategy is cost-effective. As it has been quoted, depressive symptoms are very frequently associated with diabetes. Interestingly, identified diabetes has been associated with 4-fold greater odds of depression, while undiagnosed diabetes has not been associated with depression (5). Depressive symptoms are frequent in hemodialysis (6), obstructive sleep apnea Correspondence to: Veralice Meireles Sales Bruin veralice@superig.com. br
Researches on pattern reconfigurable antenna and its application in phased array

This paper introduces the achievement and progress in the research on pattern reconfigurable antenna and its application in phased array, in Computational Electromagnetic Laboratory (CEMLAB) at UESTC. Several typical pattern reconfigurable antennas are introduced. A phased array composed of one kind of pattern reconfigurable elements is simulated on plane platform and conformal platform, and the array realize excellent scanning characteristics such as wide scanning coverage, less gain fluctuation and low cross-polarization. At last, the development trend of reconfigurable antenna is predicted in the conclusions.
6.6 A 240Hz-reporting-rate mutual-capacitance touch-sensing analog front-end enabling multiple active/passive styluses with 41dB/32dB SNR for 0.5mm diameter

A mutual-capacitance touch-sensing architecture and a system that enables concurrent usage of multiple active styluses having different properties such as color, thickness, shape, etc., are developed and verified with use of an existing touch controller [1]. An extension of the architecture to handle wireless active styluses is also developed and verified with an analog front-end (AFE) IC.
PLATELET-RICH PLASMA (PRP) AND ITS APPLICATION IN THE TREATMENT OF CHRONIC AND HARD-TO-HEAL SKIN WOUNDS. A Review

In the last few years various methods are being applied in the use of platelet-rich plasma (PRP) during treatment in different orthopedic disease. They al- low improvement of local biological condition and regen- eration of different types of tissues. PRP is a modern treat- ment strategy with worldwide recognition. There is a high concentration of platelet growth factors in small amounts of plasma. PRP and its various forms have become one of the best methods to support the healing process of various tissues. PRP is used in regenerative medicine, because it provides two of three components (growth factors and scaf- folds) necessary for complete tissue regeneration. The par- ticular reason for the appearance of lesions is important in order to select an appropriate treatment method and tech- nical application. PRP may be used for treatment of vari- ous chronic and hard-to-heal cutaneous wounds, especially when standard conventional therapy is not good enough and surgical treatment is not possible. It reduces the duration, cost of treatment and the hospital stay. There is reduction of wound pain after starting the treatment, reduced risk of blood-borne disease transmission, wound healing is re- stored, and local immunity is activated.
Resveratrol in human cancer chemoprevention--choosing the 'right' dose.

There is now robust preclinical evidence to suggest that resveratrol possesses cancer chemopreventive properties. A series of clinical pilot studies has provided insights into its pharmacokinetics, and data on its human antineoplastic pharmacodynamics start to emerge. It is likely that resveratrol will be developed further in the clinic as a putative cancer chemopreventive agent. The question that remains unresolved is: What is the most suitable dose of resveratrol for effective cancer preventive intervention? Mechanistic studies in cells in vitro have almost invariably used concentrations of resveratrol in the 10(-5) to 10(-4) M range, which is much higher than those which can be achieved in the human biophase after consumption of doses up to 1 g. Many of the preclinical efficacy studies in rodent models of carcinogenesis have employed doses which are dramatically above those which can be ingested with the diet. New experimental paradigms need to be used to obtain information on pharmacological changes elicited by resveratrol when present at very low concentrations or when administered at dietary-relevant doses.
Going beyond completeness in information retrieval

The importance of information (or content) is becoming higher as computers penetrate everyday life. This has speeded up information management researches. We focus on information retrieval in this paper and present a classification of semantic-based techniques which rely on semantic aspects of people and surroundings as well as data objects themselves. We also present the notion of cognition-based retrieval which counts our cognitive nature in retrieval processing as a new promising approach. What this means is that, as similar to the theory of relativity introduced by Einstein, information spaces should form a continuum which bends, folds or warps from the observer's point of view.
Evaluation of a Quality Improvement Intervention for Diabetes Management

The purpose of this study was to develop and test two interventions designed to improve provider compliance with diabetes management guidelines: the use of a diabetes management flowsheet inserted into patient charts and the use of a diabetes management flowsheet plus quarterly provider feedback about compliance levels. Diabetic patient charts from six family practice clinics were randomly selected and audited at baseline and at 12 months. The analysis indicated that the use of the flowsheet was associated with improved provider compliance in the completion of foot examinations only. Providers involved in the study believed that the process of the flowsheet plus feedback contributed to their greater awareness of diabetes management guidelines.
Proposed Data Quality Evaluation Method for a Transportation Agency

The data quality evaluation is essential towards designing a data assessment method for any company because data is an important asset. Therefore, the purpose of this study is to develop the data quality evaluation method for a transportation agency in Malaysia in order to quantify the quality of data in the SIKAP licensing system. This can benefit the transportation agency to improve the quality of data for the use of reporting, forecasting business operations and data integration with other agency’s systems. The relevant data evaluation dimensions have been identified from literature study and relative data evaluation framework which are necessarily required by the transportation agency to maintain high data quality in the SIKAP system. The process design for the proposed method involves data dimension identification, capturing the relevant database structure, subjective evaluation with a questionnaire and objective evaluation with data profiling. From the design process, the result shows that data evaluation method for a transportation agency must have a minimum of six data quality dimensions. SIKAP, the legacy system is in the process to revamp into a new system. Thus, this research contributes to enhance the current system’s data quality during revamping process and data migration into the new system.
Cooperative Relaying in Power Line Environment: A Survey and Tutorial

Exchange of information is essential in any society and the demand for faster, cheaper, and secure communications is increasing every day. With other hi-tech initiatives like IPv6 and Internet-of-Things (IOT) already in the horizon, demand for broadband is set to escalate beyond its current level. Inherently laden in the challenges posed by this technology are fresh opportunities in terms of penetration of data services into rural communities and development of innovative strategies for more efficient use of the grid. Though still in its developmental phase/stage, Power Line Communication (PLC) has grown beyond theoretical fantasy to become a reality. The proofs are the readily available PLC systems that can be purchased off the shelfto achieve in-house networking and the much talked about, smart metering technology; generally regarded as the “new bride” in utilities industry. One of the biggest gains of PLC is its use of existing electrical cables, thereby eliminating cost of installation and maintenance of data cables. However, given that the power infrastructure was traditionally built to deliver electricity, data signals do suffer various forms of distortions and impairments as they transit it. This paper presents a tutorial on the deployed wireless system technique which is to be adapted to PLC scenario for the purpose of managing the available source energy for achieving reliable communication system. One of these techniques is the cooperative diversity. Its application and deployment in power line environment is explored. The improvement achieved through cooperative diversity in some PLC systems were presented along with the associated limitations. Finally, future areas of research which will further improve the reliability of PLC systems and reduce its power consumption during transmission is shown
Bioactive constituents of Salvia chrysophylla Stapf

The dichloromethane extract of the aerial parts of Salvia chrysophylla Stapf (Lamiaceae), which is an endemic species to south-western Anatolia, was studied for non-volatile secondary metabolites for the first time in this study. Structures of the isolated compounds were elucidated as sclareol, β-sitosterol, salvigenin, oleanolic acid and ursolic acid. The lipid peroxidation inhibitory activity and the DPPH free radical scavenging activity of the pure isolates were investigated to establish their antioxidant potential. Their anticholinesterase activity was carried out by the Ellman assay against both enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase, and diterpene sclareol exhibited fairly good activity against both the enzymes while the two triterpenoids oleanolic and ursolic acids exhibited selective activity against AChE.
Analyzing the Effect of Perceived Value and Trust on Purchase Intention (Case Study of Zalora)

With advance progress of marketing, nowadays people don't have to waste their time walking to the store to buy things. They only need to browse the internet and search for what they want and get it in no time. With this convenience in mind, the interest in online shopping is increasing. When customers intent to purchase product from the internet, they consider about perceived value and trust. The main objective of this study is to analyze the effect of perceived value and trust on purchase intention of Zalora. The data was collected from 100 respondents and multiple regression analysis was used to test the relationship among variables. Based on indicators explained in perceived value which are experimental value, functional value, market value and trust which are ability, benevolence, integrity they has a significant partial effect on purchase intention. The result can be maintain by giving the customer the best value and obtain their trust to sustain their purchase intention.
Treatment of acute gout with injection of colchicine.

Colchicine is one of the oldest and most specific pharmaceuticals available. While newer agents such as the corticosteroids, phenylbutazone, and probenecid are valuable in the treatment of gouty arthritis, colchicine remains the most useful drug in the treatment of this disorder. Although colchicine is a remarkably safe drug, its oral administration frequently results in nausea, vomiting, and diarrhea. These manifestations act as a limiting factor and may obviate the full effectiveness of the drug. Colchicine injection is now available for intravenous administration. When the drug is given by this method, and the indicated dosage is not exceeded, gastrointestinal side-effects are rarely encountered and the response is more rapid than that obtained with the oral method. Cautious intravenous administration is also a valuable diagnostic procedure. Report of Cases Case 1. — An obese 43-year-old man developed pain and swelling of the left knee eight days after an automobile accident. There was no
Genome structure and metabolic features in the red seaweed Chondrus crispus shed light on evolution of the Archaeplastida

Red seaweeds are key components of coastal ecosystems and are economically important as food and as a source of gelling agents, but their genes and genomes have received little attention. Here we report the sequencing of the 105-Mbp genome of the florideophyte Chondrus crispus (Irish moss) and the annotation of the 9,606 genes. The genome features an unusual structure characterized by gene-dense regions surrounded by repeat-rich regions dominated by transposable elements. Despite its fairly large size, this genome shows features typical of compact genomes, e.g., on average only 0.3 introns per gene, short introns, low median distance between genes, small gene families, and no indication of large-scale genome duplication. The genome also gives insights into the metabolism of marine red algae and adaptations to the marine environment, including genes related to halogen metabolism, oxylipins, and multicellularity (microRNA processing and transcription factors). Particularly interesting are features related to carbohydrate metabolism, which include a minimalistic gene set for starch biosynthesis, the presence of cellulose synthases acquired before the primary endosymbiosis showing the polyphyly of cellulose synthesis in Archaeplastida, and cellulases absent in terrestrial plants as well as the occurrence of a mannosylglycerate synthase potentially originating from a marine bacterium. To explain the observations on genome structure and gene content, we propose an evolutionary scenario involving an ancestral red alga that was driven by early ecological forces to lose genes, introns, and intergenetic DNA; this loss was followed by an expansion of genome size as a consequence of activity of transposable elements.