Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyp levels in adults submitted to dynamic stretch in liquid medium and ground medium

Collagen catabolism in the locomotion system implies liberation of an increased hydroxyproline (HYP) level in winary excretion, which in turn constitutes a biochemical marker indicating damage in the conjunctive tissue. The objective of the present study was to verify the locomotion systems collagen catabolism degree through the HYP level excreted in 10 (ten) non – athletes adults men’s wire, with age group between 24 to 45, submitted to dynamic stretch in liquid medium or ground medium. Four movements limited by both muscular elasticity and joint mobility were selected for dynamic stretch performance and three urine sample collections were used in laboratory. As a methodological procedure sample collection was carried out for a two hour period (2:00) post hydration, and taken to the laboratory within 3 (three) hours. The HPLC – system liquid chromatographic determination of total hydroxyproline in urine – was used with reference value of 15 – 43 mg/d (Cherneeky et al., 1993). The fi rst collection was carried out 24 hours before the dynamic stretch to verify the basal level of HYP as sample group reference of volunteers. The second and the third collections were carried out 24 hours after the dynamic stretch was accomplished in both means. The results found for HYP levels (for p= 0.05) were for the basal level 39.07 + 15.27; for the levels 24 hours post – ground training were 71.28 + 12.15 and for the levels 24 hours post-water training were 66.74 + 10.31. From the results it is concluded that there is difference between the basal instants and the 24 hour post – training, indicating therefore the occurrence of damage of the conjunctive tissue. The direct analysis among the environments didn’t present a signifi cant difference (for p < 0.05). In spite of the occurrence of damage in both means with the results obtains, it isn’t possible to conclude which mean can prevail for the training with lesser risk of damage.
High-quality attack graph-based IDS correlation

Intrusion Detection Systems are widely deployed in computer networks. As modern attacks are getting more sophisticated and the number of sensors and network nodes grow, the problem of false positives and alert analysis becomes more difficult to solve. Alert correlation was proposed to analyse alerts and to decrease false positives. Knowledge about the target system or environment is usually necessary for efficient alert correlation. For representing the environment information as well as potential exploits, the existing vulnerabilities and their Attack Graph (AG) is used. It is useful for networks to generate an AG and to organize certain vulnerabilities in a reasonable way. In this article, a correlation algorithm based on AGs is designed that is capable of detecting multiple attack scenarios for forensic analysis. It can be parameterized to adjust the robustness and accuracy. A formal model of the algorithm is presented and an implementation is tested to analyse the different parameters on a real set of alerts from a local network. To improve the speed of the algorithm, a multi-core version is proposed and a HMM-supported version can be used to further improve the quality. The parallel implementation is tested on a multi-core correlation platform, using CPUs and GPUs.
Multifocal synchronous mucinous adenocarcinomas arising in congenital pulmonary airway malformation: a case report with molecular study

Congenital pulmonary airway malformation (CPAM) is a rare developmental anomaly of the lung. Here, we report a case of mucinous adenocarcinoma arising in CPAM. A 23‐month‐old boy underwent a thoracoscopic lobectomy of the left upper lobe of the lung based on a presumptive diagnosis of asymptomatic CPAM, found in antenatal sonogram.
Long-term results of laparoscopic colorectal cancer resection.

BACKGROUND Although minimally invasive surgery has been accepted for a variety of disorders, laparoscopic resection of colorectal cancer is performed by few. Concern about oncological radicality and long term outcome has limited the adoption of laparoscopic surgery for colorectal cancer. OBJECTIVES To determine long-term outcome after laparoscopically-assisted versus open surgery for non-metastasised colorectal cancer. SEARCH STRATEGY The Cochrane library, EMBASE, Pub med and Cancer Lit were searched for published and unpublished randomised controlled trials. SELECTION CRITERIA Randomised clinical trials comparing laparoscopically-assisted and open surgery for non-metastasised colorectal cancer were included. Studies that did not report any long-term outcomes were excluded. DATA COLLECTION AND ANALYSIS Two reviewers independently assessed the studies and extracted data. RevMan 4.2 was used for statistical analysis. MAIN RESULTS Thirty-three randomised clinical trials (RCT) comparing laparoscopically-assisted versus open surgery for colorectal cancer were identified. Twelve of these trials, involving 3346 patients, reported long-term outcome and were included in the current analysis. No significant differences in the occurrence of incisional hernia, reoperations for incisional hernia or reoperations for adhesions were found between laparoscopically assisted and open surgery (2 RCT, 474 pts, 7.9% vs 10.9%;P = 0.32 and 2 RCT, 474 pts, 4.0% vs 2.8%; P = 0.42 and 1 RCT, 391 pts, 1.1% vs 2.5%;P = 0.30, respectively). Rates of recurrence at the site of the primary tumor were similar (colon cancer: 4 RCT, 938 pts, 5.2% vs 5.6%; OR (fixed) 0.84 (95% CI 0.47 to 1.52)(P = 0.57); rectal cancer: 4 RCT, 714 pts, 7.2% vs 7.7%; OR (fixed) 0.81 (95% CI 0.45 to 1.43) (P = 0.46). No differences in the occurrence of port-site/wound recurrences were observed (P=0.16). Similar cancer-related mortality was found after laparoscopic surgery compared to open surgery ( colon cancer: 5 RCT, 1575 pts, 14.6% vs 16.4%; OR (fixed) 0.80 (95% CI 0.61 to 1.06) (P=0.15); rectal cancer: 3 RCT, 578 pts, 9.2% vs 10.0%; OR (fixed) 0.66 (95% CI 0.37 to 1.19) (P=0.16). Four studies were included in the meta-analyses on hazard ratios for tumour recurrence in laparoscopic colorectal cancer surgery. No significant difference in recurrence rate was observed between laparoscopic and open surgery (hazard ratio for tumour recurrence in the laparoscopic group 0.92; 95% CI 0.76-1.13). No significant difference in tumour recurrence between laparoscopic and open surgery for colon cancer was observed (hazard ratio for tumour recurrence in the laparoscopic group 0.86; 95% CI 0.70-1.08). AUTHORS' CONCLUSIONS Laparoscopic resection of carcinoma of the colon is associated with a long term outcome no different from that of open colectomy. Further studies are required to determine whether the incidence of incisional hernias and adhesions is affected by method of approach. Laparoscopic surgery for cancer of the upper rectum is feasible, but more randomised trials need to be conducted to assess long term outcome.
Representing strategic games and their equilibria in many-valued logics

We introduce the notion of logical A-games for a fairly general class of algebras A of real truth-values. This concept generalizes the Boolean games of Harrenstein et al. as well as the recently defined Lukasiewicz games of Marchioni and Wooldridge. We demonstrate that a wide range of strategic n-player games can be represented as logical A-games. Moreover we show how to construct, under rather general conditions, propositional formulas in the language of A that correspond to pure and mixed Nash equilibria of logical A-games.
High incidence of Epstein–Barr virus (EBV)‐positive Hodgkin lymphoma and Hodgkin lymphoma‐like B‐cell lymphoproliferations with EBV latency profile 2 in children with interleukin‐2‐inducible T‐cell kinase deficiency

Interleukin‐2‐inducible T‐cell kinase (ITK) deficiency is an inherited T‐cell deficiency characterized by the development of Epstein–Barr virus (EBV)‐associated lymphoproliferations. We aimed to describe the histopathological features of lymphoproliferative processes arising in ITK deficiency, and to compare them with lymphoproliferations in otherwise immunocompromised patients.
Discordant human epidermal growth factor receptor 2 overexpression in primary and metastatic upper gastrointestinal adenocarcinoma signifies poor prognosis

Targeted therapy with trastuzumab has proved to be effective for patients with gastric cancer overexpressing the human epidermal growth factor receptor 2 (HER2). Further studies are needed to determine the best method for assessment of HER2 overexpression. Moreover, the prognostic value of HER2 overexpression, including the significance of tumour heterogeneity, remains unclear.
Adaptation of the Egg of the Desert Beetle, Microdera punctipennis (Coleoptera: Tenebrionidae), to Arid Environment

Abstract Microdera punctipennis Kaszab (Coleoptera: Tenebrionidae) is an endemic species in Guerbantonggut desert in China. To explore the ways that M. punctipennis egg adapts to dry desert environment, morphological characteristics of the egg was investigated along with the egg of the nondesert beetle Tenebrio molitor (Coleoptera: Tenebrionidae). Water loss rate and survival rate of these eggs under different dry treatments (relative humidity0, 10, and 20%) were measured to evaluate the desiccation resistance of the eggs at different developmental stages (day 0, 2, and 5 eggs). Our results showed that the 50-egg weight in T. molitor was heavier than M. punctipennis , while the 50-first-instar larva weight in T. molitor was almost the same as in M. punctipennis . The water loss rate of M. punctipennis egg under dry conditions was significantly lower than T. molitor , and the egg survival rate was significantly higher than T. molitor . The estimated developmental threshold temperature of M. punctipennis egg was 18.30°C, and the critical thermal maximum of M. punctipennis egg is above 39°C. These features partly account for the adaptability of M. punctipennis to desert environment in egg stage.
Repellence Produced by Monoterpenes on Rhodnius prolixus (Hemiptera: Reduviidae) Decreases After Continuous Exposure to These Compounds

Abstract Botanical monoterpenes are secondary metabolites present in essential oils produced by plants. Some of them are insect repellents. The bloodsucking bug Rhodnius prolixus Ståhl (Hemiptera: Reduviidae) is one of the main vectors of Chagas disease in the north of South America and some countries in Central America. In this study, we studied the repellence produced by two monoterpenes, menthyl acetate and geraniol, on fifth instar nymphs of R. prolixus . In the absence of other stimuli, both menthyl acetate and geraniol produced a repellent effect from 740 μg/cm 2 and 74 μg/cm 2 , respectively. Pre-exposure to each monoterpene reduced the repellent activity produced by the same substance. Additionally, pre-exposure to one monoterpene decreased the behavioral response of the nymphs to the other one. The repellent effect of both monoterpenes also decreased when nymphs’ antennae were previously treated with the nitric oxide donor S-nitroso-N-acetyl-cysteine.
Temperature- and CO 2 -Dependent Life Table Parameters of Spodoptera litura (Noctuidae: Lepidoptera) on Sunflower and Prediction of Pest Scenarios

Abstract Predicted increase in temperature and atmospheric CO 2 concentration will influence the growth of crop plants and phytophagous insects. The present study, conducted at the Central Research Institute for Dryland Agriculture, Hyderabad, India, aimed at 1) construction of life tables at six constant temperatures viz . , 20, 25, 27, 30, 33, and 35 ± 0.5°C for Spodoptera litura (Fabricius) (Noctuidae: Lepidoptera) reared on sunflower ( Helianthus annus L.) grown under ambient and elevated CO 2 ( e CO 2 ) (550 ppm) concentration in open top chambers and 2) prediction of the pest status in near future (NF) and distant future (DF) climate change scenarios at major sunflower growing locations of India. Significantly lower leaf nitrogen, higher carbon and higher relative proportion of carbon to nitrogen (C:N) were observed in sunflower foliage grown under e CO 2 over ambient. Feeding trials conducted on sunflower foliage obtained from two CO 2 conditions showed that the developmental time of S. litura (Egg to adult) declined with increase in temperature and was more evident at e CO 2 . Finite (λ) and intrinsic rates of increase ( rm ), net reproductive rate ( Ro ), mean generation time, (T) and doubling time (DT) of S. litura increased significantly with temperature up to 27–30°C and declined with further increase in temperature. Reduction of ‘ T ’ was observed from maximum value of 58 d at 20°C to minimum of 24.9 d at 35°C. The DT of population was higher (5.88 d) at 20°C and lower (3.05 d) at 30°C temperature of e CO 2 . The data on these life table parameters were plotted against temperature and two nonlinear models were developed separately for each of the CO 2 conditions for predicting the pest scenarios. The NF and DF scenarios temperature data of four sunflower growing locations in India is based on PRECIS A1B emission scenario. It was predicted that increased ‘ rm ’, ‘λ’, and ‘ Ro ’ and reduced ‘ T ’ would occur during NF and DF scenario over present period at all locations. The present results indicate that temperature and CO 2 are vital in influencing the population growth of S. litura and pest incidence may possibly be higher in the future.
History of Thyroid Cytology in Japan and Reporting System Recommended by the Japan Thyroid Association

144 1024x768 The present paper introduces the history of thyroid cytology and the traditional clinical managements of patients with indeterminate cytology in Japan because most literatures on this subject have been published in Japanese and limited publications are available in English. The Japan Thyroid Association has recently published a guideline for clinical practice for the management of thyroid nodules and this paper introduces its diagnostic system for reporting thyroid cytology. There are three aspects slightly different from the existing internationally recognized reporting systems. First is the so-called ‘cyst fluid only’ samples which contain only few or no follicular cells, and those samples are classed to ‘benign category’ in the Japan Thyroid Association reporting system for thyroid cytology. The second is the sub-classification of so-called ‘indeterminate’ category that is divided into ‘follicular neoplasm’ and ‘others’. The third is the so-called sub-classification of ‘follicular neoplasm’ into ‘favor benign’ (low-risk), ‘borderline’ (moderate-risk) and ‘favor malignant’ (high-risk), which has been adapted from the high volume thyroid disease centers in Japan. This is because diagnostic surgery for all patients with follicular neoplasms is not a standard practice in Japan and most Japanese clinicians apply further risk stratification to identify higher-risk patients who should undergo surgery. The Japan Thyroid Association reporting system uses self-explanatory terminologies and provides a flexible choice of either a simple 6-tier (without stratification of follicular neoplasm), comparable to other internationally recognized reporting systems, or a more complicated 8-tier system for further risk stratification of patients. The reporting system is believed to be useful to reduce the number of unnecessary surgical procedures, particularly for those patients with benign nodules. Normal 0 false false false
Linear growth of children in papua new guinea in relation to dietary, environmental and genetic factors

Linear growth rates in rural Papua New Guinea vary widely by environmental zone. The 1982/83 National Nutrition Survey was a stratified cluster sample survey including questions on diet and anthropometry of children under five years of age. Regression analyses including 25,022 children from this survey show that variation in stature by altitude and precipitation level can largely be accounted for by differences in the fat and protein contents of village diets. Differences in linear growth rate between children living on different landforms show less relationship with diet. Genetic distances based on Class I HLA gene frequencies were calculated for 29 populations. Population mean recumbent lengths were estimated adjusted for age, diet, and environmental variables. The differences between populations in these average lengths were calculated. No significant correlation was found between genetic distances and differences in length. Genetic differences between ancestral populations as tracked by the HLA system do not appear to be an important factor contributing to variation in linear growth of Papua New Guinean children.
Meta-analysis of Diagnostic Test Evaluation Data: Random Effects Approaches

Objective: When studies report proportions such as sensitivity or specificity, it is customary to meta-analyze them using the DerSimonian and Laird random effects model. This method approximates the within-study variability of the proportion by a normal distribution, which may lead to bias for several reasons. Alternatively an exact likelihood approach based on the binomial within-study distribution can be used. This method can easily be performed in standard statistical packages. We investigate the performance of the standard method and the alternative approach. Study Design and Setting: We compare the two approaches through a simulation study, in terms of bias, means squared error and coverage probabilities. We varied the size of the overall sensitivity or specificity, the between-studies variance, the within-study sample sizes and the number of studies. The methods are illustrated using a published meta-analysis data set. Results: The exact likelihood approach performs always better than the approximate approach and gives unbiased estimates. The coverage probability, in particular for the profile likelihood, is also reasonably acceptable. In contrast, the approximate approach gives huge bias with very poor coverage probability in many cases. Conclusion: The exact likelihood approach is the method of preference and should be used whenever feasible.
Reduction of the number of fetuses for women with a multiple pregnancy.

BACKGROUND When couples are faced with the dilemma of a higher-order multiple pregnancy there are three options. Termination of the entire pregnancy has generally not been acceptable to women, especially for those with a past history of infertility. Attempting to continue with all the fetuses is associated with inherent problems of preterm birth, survival and long-term morbidity. The other alternative relates to reduction in the number of fetuses by selective termination. The acceptability of these options for the couple will depend on their social background and underlying beliefs. This review focused on reduction in the number of fetuses. OBJECTIVES To assess a policy of multifetal reduction with a policy of expectant management of women with a multiple pregnancy. SEARCH METHODS We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (13 June 2012). SELECTION CRITERIA Randomised controlled trials with reported data that compared outcomes in mothers and babies who were managed expectantly with outcomes in women who underwent selective fetal reduction of a multiple pregnancy. DATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted data. MAIN RESULTS There were no randomised controlled trials identified. AUTHORS' CONCLUSIONS We found no available data from randomised trials to inform the risks and benefits of pregnancy reduction procedures for women with a multiple pregnancy. While randomised controlled trials will provide the most reliable evidence about the risks and benefits of fetal reduction procedures, reduction in the number of fetuses by selective termination may not be acceptable to women, particularly couples with a past history of infertility. The acceptability of this option, and willingness to undergo randomisation will depend on the couple's social background and beliefs, and consequently, recruitment to such a trial may prove exceptionally difficult.
Intratumoral stromal morphometry predicts disease recurrence but not response to 5‐fluorouracil—results from the QUASAR trial of colorectal cancer

The biological importance of tumour‐associated stroma is becoming increasingly apparent, but its clinical utility remains ill‐defined. For stage II/Dukes B colorectal cancer (CRC), clinical biomarkers are urgently required to direct therapeutic options. We report here prognostic/predictive analyses, and molecular associations, of stromal morphometric quantification in the Quick and Simple and Reliable (QUASAR) trial of CRC.
Renal NUT carcinoma: a case report

Nuclear protein in testis (NUT)-midline carcinomas were first described more than two decades ago with characteristic reciprocal translocations involving BRD4 on chromosomes 15 and NUTM1 on chromosome 19 (1). Over the years, these tumors have been reported in non-midline locations as well as outside of the upper aerodigestive tract and mediastinum. We recently encountered a renal NUT carcinoma (NC) diagnosed next generation sequencing (NGS) that is reported here. This article is protected by copyright. All rights reserved.