Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina.

The soluble antigen involved in the pathogenesis of EAU was isolated from bovine retinal extract by precipitation with ammonium sulfate followed by molecular sieve and ion exchange chromatography. The purified fraction formed a double precipitin band by immunodiffusion and immunoelectrophoresis, and a doublet by analytical disc electrophoresis. By immunodiffusion one of these components formed a reaction of identity with guinea pig S antigen and the other a reaction of partial identity. Because the two components had the same m.w. and similar electric mobility, they are presumed to be minor structural variants of the same molecule. The purified antigen had a m.w. of approximately 102,000 by analytical ultracentrifugation, 50,500 by SDS electrophoresis, and 56,000 by gel filtration chromatography. Sedimentation velocity studies with increasing concentrations of antigen indicated self-association. An S20 value of 3.6 was obtained for the monomer, corresponding to an approximate m.w. of 50,000. The antigen was identified as a protein with a very small amount of lipid. Data are presented on the absorption spectrum, extinction coefficient, and amino acid composition. The molecule was lacking in cysteine and tryptophan, but contained a relatively high proportion of nonpolar amino acids corresponding with a lipophilic protein. It was localized by immunofluorescence to the area surrounding the entire photoreceptor cell in a pattern indicating association with the plasma membrane. The antigen was not rhodopsin, which has been implicated as a probable antigen in the pathogenesis of EAU, but has some properties resembling a recently described photoreceptor cell retinol-binding protein tentatively implicated in the transport of vitamin A from the circulation to the retina. Assay of the purified fraction for production of EAU in the guinea pig indicated it was highly pathogenic in the microgram range. In agreement with immunofluorescent findings, the photoreceptors were specifically destroyed after cellular infiltration of the uveal tract.
Anaerobic capacity of the upper arms in top-level team handball players.

PURPOSE Handball is a sport with high anaerobic demands in lower body as has been indicated by Wingate test (WT) performed with the legs, but there are no data available concerning power production during a WT performed with the arms in handball players (HndP). Therefore, the purpose of this study was to explore the arm anaerobic profile of HndP during a WT. METHODS Twenty-one elite HndP and 9 physical education students (CON), performed a 30-s arm WT. Power production and muscle oxygenation were recorded. RESULTS Peak power (PP) as well as mean power (MP) was higher (P = .017 and 0.03, and ES = 1.00 and 0.86, respectively) for HndP (HndP PP: 7.6 +/- 0.8 W x kg(-1); CON PP: 6.7 +/- 1.1 W x kg(-1); HndP MP 5.3 +/- 0.6 W x kg(-1); CON MP 4.7 +/- 0.9 W x kg(-1)) with no significant difference in fatigue index between the two groups. Muscle oxygen saturation (StO2) declined approximately 30% with exercise with no differences between groups. During recovery the HndP group had higher StO2 (P = .01, ES= 3.04), total hemoglobin and oxygenated hemoglobin compared with the CON group (P < .01 ES = 3.29 and 0.99, respectively). StO2 returned to resting values in 29.5 +/- 2.3 s in HndP, whereas this variable did not recover after 2 min in CON. CONCLUSIONS The arm anaerobic capacity of the HndP was "excellent," significantly higher than that by the control group. Moreover, HndP exhibited faster recovery of StO2 compared with the control group. The greater power output and the faster muscle reoxygenation of arms in HndP can be attributed to specific training adaptations related to high performance in handball.
HERITABILITY AND CORRELATION ANALYSIS FOR MORPHOLOGICAL AND BIOCHEMICAL TRAITS IN BRASSICA CARINATA

The present research was undertaken to estimate variation and heritability of some morphological and biochemical traits of introduced Ethiopian mustard genotypes. The experiment was carried out in randomized complete block design with three replications at the University of Agriculture Peshawar during 2011-2012. Analysis of variance showed highly significant differences among Brassica Carinata lines for studied parameters. Phenotypic coefficient of variation and genotypic coefficient of variation ranged from 4.92-48.24% and 3.2-38.1%, respectively. The highest heritability values were recorded for pod length (0.83) followed by pods on main raceme (0.82). Genetic advance (as percent of mean) was the highest for seed yield plant -1 and pods on main raceme. Highly significant positive phenotypic correlation for seed yield plant -1 was observed with plant height and primary branches plant -1 whereas significant positive phenotypic correlation was observed with seed pod -1 , while oil content was significantly positive correlated only with erucic acid. Carinata-29, Carinata-38, Carinata-45, Carinata-7, Carinata-47 and Carinata-83 were superior for seed yield and yield contributing traits, whereas Carinata-70 was the best for oil quality traits. On overall basis, carinata70 and carinata-83 were the best lines hence could be used in breeding programs.
Total Pancreatectomy and Islet Autotransplantation in Children for Chronic Pancreatitis: Indication, Surgical Techniques, Postoperative Management, and Long-Term Outcomes

Objective:Describe the surgical technique, complications, and long-term outcomes of total pancreatectomy and islet autotransplantation (TP-IAT) in a large series of pediatric patients. Background:Surgical management of childhood pancreatitis is not clear; partial resection or drainage procedures often provide transient pain relief, but long-term recurrence is common due to the diffuse involvement of the pancreas. Total pancreatectomy (TP) removes the source of the pain, whereas islet autotransplantation (IAT) potentially can prevent or minimize TP-related diabetes. Methods:Retrospective review of 75 children undergoing TP-IAT for chronic pancreatitis who had failed medical, endoscopic, or surgical treatment between 1989 and 2012. Results:Pancreatitis pain and the severity of pain statistically improved in 90% of patients after TP-IAT (P < 0.001). The relief from narcotics was sustained. Of the 75 patients undergoing TP-IAT, 31 (41.3%) achieved insulin independence. Younger age (P = 0.032), lack of prior Puestow procedure (P = 0.018), lower body surface area (P = 0.048), higher islet equivalents (IEQ) per kilogram body weight (P = 0.001), and total IEQ (100,000) (P = 0.004) were associated with insulin independence. By multivariate analysis, 3 factors were associated with insulin independence after TP-IAT: (1) male sex, (2) lower body surface area, and (3) higher total IEQ per kilogram body weight. Total IEQ (100,000) was the single factor most strongly associated with insulin independence (odds ratio = 2.62; P < 0.001). Conclusions:Total pancreatectomy and islet autotransplantation provides sustained pain relief and improved quality of life. The &bgr;-cell function is dependent on islet yield. Total pancreatectomy and islet autotransplantation is an effective therapy for children with painful pancreatitis that failed medical and/or endoscopic management.
Intuitionistic Fuzzy Expert System based Fault Diagnosis using Dissolved Gas Analysis for Power Transformer

In transformer fault diagnosis, dissolved gas analysis (DGA) is been widely employed for a long period and numerous methods have been innovated to interpret its results. Still in some cases it fails to identify the corresponding faults. Due to the limitation of training data and non-linearity, the estimation of key-gas ratio in the transformer oil becomes more complicated. This paper presents Intuitionistic Fuzzy expert System (IFS) to diagnose several faults in a transformer. This revised approach is well suitable to diagnosis the transformer faults and the corresponding action to be taken. The proposed method is applied to an independent data of different power transformers and various case studies of historic trends of transformer units. It has been proved to be a very advantageous tool for transformer diagnosis and upkeep planning. This method has been successfully used to identify the type of fault developing within a transformer even if there is conflict in the results of AI technique applied to DGA data.
Socio-Demographic Factors and Health-Oriented Behaviors of University Students in the Podkarpackie Region. Long-Term Prospective Research

The aim of the study was to achieve a prospective long-term evaluation of the impact of socio-demographic factors on students, and their healthy behaviors. It was a diagnostic survey employing a standardized interview questionnaire. The survey was conducted among 905 first-year students of medical and non-medical faculties (18–19 years of age), and the University of Rzeszów, and Rzeszów University of Technology. It was conducted in 2009 and repeated two years later. The rating of the behavior patterns of students was conducted in accordance with the following schedule: October 2009 – January 2010 (T1), October 2011 – January 2012 (T2). The level of healthy behaviors in 2012 increased significantly in a positive direction compared to 2009 (p < 0,001), in particular in the category: proper eating habits (p < 0,001) and preventive behaviors (p < 0,001). In 2009 men in the first year of the study had a lower level of healthy behaviors, an average of 3,63 points, than women (T1) and in 2012 of 5,42 points lower (T2). The level of healthy behaviors in 2012 increased significantly in a positive direction compared to 2009, in particular in the category: proper eating habits and preventive behaviors. Women showed more pro-health attitudes than men. The pro-health attitudes characterized by medical students was seen in a greater degree.
PARTITIONING AND ECOLOGICAL RISK ASSESSMENT OF HEAVY METALS IN SURFICIAL SEA AND LAKE SEDIMENTS

EXTENDED ABSTRACT Chemical speciation or partitioning of heavy metals in soils and sediments is important in evaluating their mobility, toxicity and bioavailability. In general, the organic forms of metals are more toxic than their inorganic forms. In environmental samples such as soils or sediments, it is important to ascertain the availability and distribution of metals. Tessier developed a method for sequential extraction that separates metals in sediments into five different metal fractions: (1) Exchangeable, (2) Bound to carbonates, (3) Bound to iron and manganese oxides, (4) Bound to organic matter and (5) Residual. Heavy metals present in each of these fractions have different (re)mobilization behaviours under specific environmental conditions. The first fraction includes the loosely held contaminants that can be readily extracted, therefore mild extracting conditions are required. The second fraction regards tightly adsorbed contaminants and those associated with carbonates and easily soluble oxides/hydroxides under slightly acidic conditions. The third fraction involves contaminants that are associated with Fe-Mn oxides and the fourth, contaminants associated with easily oxidizable solids or compounds, including organic matter. Finally, the last step of the Tessier method involves contaminants present as consolidated oxides, co-precipitates, and strongly held complexes. In the present study we examined the partitioning of heavy metals from four sediment samples collected from Elefsis Bay (labelled as E1, E2, E3, E4) and from four sediments samples taken from Koumoundourou Lake (labelled as K1, K2, K3, K4), Athens, Greece. Every one of them was treated by applying Tessier's five step sequential extraction procedure. As far as sediments from the gulf are concerned, the results indicated that Cu exhibits a strong affinity to the organic matter with percentages ranging from 65%-78% of the total. Considerable Zn (32%-40%) is bound to Fe-Mn oxides and most of the non-residual Cr and Ni are associated with the organic fraction, mainly due to the organic matter in sediments, an observation that suits all heavy metals examined. As for the sediments collected from the Lake, percentages of heavy metals bound to the organic matter are slightly higher in samples taken from the north side of the Lake and Pb is the predominant metal bound to Fe-Mn (48%-51%). Moreover, Ni and Cr in sediments K2 and K4 are bound to Fe-Mn oxides and organic matter in higher percentages than in sediments K1 and K3, mainly due to the existence of more organic matter in the first two. It is also noteworthy the percentage of Zn bound to carbonated fraction (5%-15%) indicating biological availability. Concluding, after the application of several risk assessment indicators, such as RAC (Risk Assessment Code), RI (Risk Index) and Igeo (Geoaccumulation Index), Elefsis gulf sediments correspond to a moderate pollution level, whereas Koumoundourou Lakes' basin can be characterized as of "low risk".
RETAINED FOETAL MEMBRANE IN COWS OF KASHMIR VALLEY : PREVALENCE AND MANAGEMENT

A total of 51 cases of retained foetal membrane in cattle were used to ascertain the prevalence and outcome of two different treatment protocols. Highest prevalence was observed in 3'd parity (37.25%) at 6 and 7 years of age (27.45%) and in spring season (33.33%). More prevalence was recorded in the dams with female (54.90%) and live fetuses (80.39%). A close relationship of retained foetal membrane was observed with dystocia, hypocalcaemia, abortion, premature delivery and twinning. As a treatment protocol, partial manual removal of retained foetal membrane followed by oral use of ecbolics and uterotonic liquid was found better as compared to complete manual removal.
g-C 3 N 4-Based Nanomaterials for Visible Light-Driven Photocatalysis

Graphitic carbon nitride (g-C3N4) is a promising material for photocatalytic applications such as solar fuels production through CO2 reduction and water splitting, and environmental remediation through the degradation of organic pollutants. This promise reflects the advantageous photophysical properties of g-C3N4 nanostructures, notably high surface area, quantum efficiency, interfacial charge separation and transport, and ease of modification through either composite formation or the incorporation of desirable surface functionalities. Here, we review recent progress in the synthesis and photocatalytic applications of diverse g-C3N4 nanostructured materials, and highlight the physical basis underpinning their performance for each application. Potential new architectures, such as hierarchical or composite g-C3N4 nanostructures, that may offer further performance enhancements in solar energy harvesting and conversion are also outlined.
Rat brain oligodendrocytes do not interact selectively with axons expressing different calcium‐binding proteins

A single oligodendrocyte may endow ten to twenty vicinal axons with internodal segments, but its radial domain is neither exclusive of processes from other like cells nor are all nerve fibres within this zone myelinated. Whether oligodendrocytes are able to discriminate between axons on the basis of chemical or electrophysiological differences, or whether the tactic response is random, has yet to be established. In order to shed some light on this process, we investigated the ensheathment, by single oligodendrocytes, of axons distinguished on the basis of their calcium‐binding protein complexion. Rat brain oligodendrocytes were visualized either with the Rip‐antibody or by intracellular injection of Lucifer Yellow; subclasses of axons were immunolabelled with antibodies against one of the two calcium‐binding proteins parvalbumin or calretinin. Individual oligodendrocytes did not exhibit exclusivity with respect to their preferment for axons containing calcium‐binding proteins, associations with both non‐immunoreactive, as well as with parvalbumin‐ or calretinin‐positive ones, being encountered. © 1996 Wiley‐Liss, Inc.
Thiotepa‐based conditioning for allogeneic stem cell transplantation in acute lymphoblastic leukemia—A survey from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

In this study, we analyzed a thiotepa‐based conditioning regimen for allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia, using the EBMT database. A total of 323 patients were identified. The median age was 43 years. Disease status at transplant was first complete remission (CR1) in 48.9%, CR2 in 21.7%, CR3 in 6.2%, while 23.2% of the patients had an active disease at the time of transplant. This was performed from a HLA‐matched sibling (49.8%) or a matched‐unrelated donor (51.2%). The incidence of acute graft‐vs.‐host disease (GvHD) (grade > II) was 26.6%, while chronic GvHD occurred in 35.9% of the patients at 1 year (24.6% with extensive disease). With a median follow‐up of 16.8 months, the nonrelapse mortality was 12.4 and 25.3% at 100 days and 1 year, respectively. The relapse incidence at 1 year was 33.3% with no difference for patients in CR1 (27%). The one‐year leukemia‐free survival (LFS) and overall survival (OS) were 57 and 66%, respectively for the entire cohort and 50 and 66%, respectively in patients in CR1. Thiotepa/busulfan ± melphalan (n = 213) in comparison to thiotepa/other (n = 110) conditioning regimen resulted in higher relapse incidence at 1 year (34.9 vs. 30.3%, P = 0.016) and lower LFS (38.8 vs. 45.9%, P = 0.0203), while nonrelapse mortality (23.8 vs. 26.3%, n.s.) and OS (59.6 vs. 51.1%, P = 0.109) did not differ. This large study suggests that a thiotepa‐based conditioning for allogeneic transplantation in acute lymphoblastic leukemia is feasible and effective, with the main outcomes being comparable to those achieved with other regimens. Am. J. Hematol. 92:18–22, 2017. © 2016 Wiley Periodicals, Inc.
Na,K‐ATPase as a Signal Transducer

Abstract: Recent studies have indicated that Na,K‐ATPase may, in addition to being the key regulator of intracellular Na+ and K+ concentration, act as a signal transducer. Despite extensive research, the biological role for ouabain, a natural ligand of Na,K‐ATPase, is not well understood. We have reported that exposure of rat proximal tubular cells (RPTC) to doses of ouabain that inhibit the Na,K‐ATPase activity by less than 50% (10 nM ‐ 500 μM), will induce intracellular [Ca2+]i oscillations and that this calcium signal leads to activation of the transcription factor NF‐κB. The ouabain‐induced calcium oscillations were blocked by an inhibitor of the IP3 receptors but not by phospholipase C inhibitors nor by cellular depletion of IP3, suggesting that the calcium signal is not due to phospholipase C‐mediated IP3 release. Fluorescence resonance energy transfer (FRET) studies suggested a close proximity between the Na,K‐ATPase and IP3 receptor. Our findings demonstrate a novel principle for calcium signaling via Na,K‐ATPase.
A study of Pareto and Two-Phase Local Search Algorithms for Biobjective Permutation Flowshop Scheduling

In many practical problems, several conflicting criteria exist for evaluating solutions. In this thesis we study stochastic local search algorithms for biobjective permutation flow shop scheduling problems. In particular, we tackle three such problems that arise from considering all pairwise combinations of the objectives (i) makespan, (ii) the sum of the completion times of the jobs, and (iii) the weighted (and by extension, the total) tardiness of all jobs. The algorithms proposed herein are combinations of two local search methods: the two-phase local search and Pareto local search. The design of the algorithms is based on a careful experimental analysis of crucial algorithmic components of the two search methods. The final results show that the newly developed algorithms reach very high performance: The solutions obtained frequently improve upon the best nondominated solutions previously known, while requiring shorter computation times.
Smart Architectural Surface : Modularized Platform for Polymorphic Functional Changes and Multimodal Interactions

Smart Architectural Surface is a highly integrated planar construct for diversified smart home services with networked smart cell units equipped with various sensing, cognition, and actuation capabilities that would allow run-time polymorphism as the basis for functional changes for various event-driven operation scenarios. The SAS system can demonstrate the outcomes of collective intelligence that are mediated by various multi-modal interactions. Current SAS prototype is capable of polymorphous functional changes for dynamically adjustable electronic wallpaper, location/distance-aware video conferencing, personalized information browser, and automatic responses to various unintended events. Future applications would harness machine learning and machine vision techniques.
GABA as a potential transmitter in lizard photoreceptors: Immunocytochemical and biochemical evidence

The retina of the desert night lizard, Xantusia vigilis, was examined for immunoreactivity to antibodies against γ‐aminobutyric acid and L‐glutamate decarboxylase. At the electron microscopic level it was found that a distinct population of the photoreceptor cells was immunoreactive to both antibodies. Computer‐assisted reconstruction of serial sections positively identified the immunoreactive receptors as cones. These cones constituted 15% of the photoreceptors in the retinal sections, and they were morphologically distinct. The mean diameter of the labeled cone synaptic pedicles was 5.8 μm whereas that of the unlabeled pedicles was 7.9 μm, a statistically significant difference. L‐glutamate decarboxylase was extracted from the lizard brain, positively identified radiometrically, and shown by immuno‐diffusion to crossreact with the antibody used for localization. The authors suggest that the immunoreactive cones synthesize and accumulate γ‐aminobutyric acid. Whether or not it is used by those cones as a neurotransmitter should be tested directly.
EXPERIMENTAL INVESTIGATION OF SPRAY COOLING OF HORIZONTALLY AND VERTICALLY ORIENTED SURFACES

The spray cooling of stainless steel plates was studied using different orientations of the cooled surface. A 1.5 mm-thick test plate was moved vertically or horizontally with a velocity of 3 m/s. Experiments were conducted with mist nozzles oriented either vertically with the spray flowing down or horizontally. The water impingement density was between 0.93– 9.68 kg m 2 s -1 . It was found that the heat transfer coefficient is similar for horizontally and vertically down oriented nozzles within the surface temperature range of 700– 900°C. The vertically down spray yields a higher heat transfer coefficient for surface temperatures below 300 °C. Furthermore, it was observed that the Leidenfrost temperature is slightly higher for vertically down spray for lower water impingement densities. This shift of the Leidenfrost temperature was not observed for higher water impingement densities.
Cortical Thickness in Young Treatment-Naive Children With ADHD

Objective: This study aimed to investigate the cortical thickness in areas of the brain that are hypothesized to be involved in response inhibition and error-monitoring behaviors. The authors hypothesized that children with ADHD would have a thinner prefrontal cortex (PFC) and anterior cingulate cortex (ACC) than healthy children. Method: In all, 25 ADHD and 25 healthy control male children (5-12 years) underwent magnetic resonance imaging. Results: The authors found thinner right superior frontal gyrus in ADHD patients compared with controls (t = 2.01, df = 45, p = .049). The older children with ADHD drove this effect when participants were further subdivided into a younger and older age group (older participants: p = .004; younger participants: p = ns). Conclusion: These findings have implications for the developmental trajectory of the frontal lobe in ADHD.