Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of urinary 5-L-oxoproline (L-pyroglutamate) during normal pregnancy in women in England and Jamaica

Urinary 5-L-oxoproline was measured during normal pregnancies in Southampton, England and Kingston, Jamaica. The CV of 5-L-oxoproline excretion in urine, determined over 7 d in a non-pregnant woman and three pregnant women, was 10–36%. Compared with non-pregnant women, urinary 5-L-oxoproline increased three to four times from early pregnancy in women in Southampton, a highly significant difference, and remained elevated at similar levels during mid and late pregnancy. For women in Kingston, the excretion of 5-L-oxoproline was similar to that of Southampton women in the non-pregnant group and during early pregnancy. However, there was a progressive increase in the excretion of 5-L-oxoproline as pregnancy advanced and by late pregnancy excretion was from three to ten times greater than the average for the non-pregnant women. There was a significant difference between the women in Southampton and the women in Kingston during mid and late pregnancy, with women in Kingston excreting twice as much 5-L-oxoproline during late pregnancy. If the excretion of 5-L-oxoproline is a measure of glycine insdciency, the results would indicate that in some pregnancies the ability of the mother to provide glycine for herself and the developing fetus is marginal or inadequate and the constraint appears more marked in Jamaica than in England.
Testicular versus ejaculated spermatozoa in ICSI cycles of normozoospermic men with high sperm DNA fragmentation and previous ART failures

As a part of male assessment, conventional sperm parameters including morphologic features have been dedicated as major factors influencing fertilisation and pregnancy rates in assisted reproductive technology (ART). Genomic integrity of spermatozoa has also been found to influence fertility prognosis, and hence, sperm DNA fragmentation index (DFI) has been adopted by many centres to document this entity. Despite several suggested approaches, there is lack of universal consensus on optimising fertility outcomes in males with high sperm DFI. In this context, the results from cycles using testicular spermatozoa (TESA) obtained by aspiration were compared with those of ejaculated spermatozoa (EJ) in normozoospermic subjects with high sperm DFI and previous ART failures. Clinical (41.9% versus 20%) and ongoing pregnancy rates (38.7% versus 15%) were significantly better and miscarriages were lower in TESA group when compared to EJ group. Sperm DFI should be a part of male partner's evaluation following unsuccessful ART attempts. When high DFI is detected (>30%), ICSI using testicular spermatozoa obtained by TESA seems an effective option particularly for those with repeated ART failures in terms of clinical, ongoing pregnancies and miscarriages even though conventional sperm parameters are within normal range.
Radio frequency electromagnetic fields in large conducting enclosures: effects of apertures and human bodies on propagation and field-statistics

Radio frequency propagation in an electrically large resonant chamber (a screened room) was simulated by two models: a statistical combination of multiple resonant modes and a computational electromagnetic simulation [the transmission line matrix (TLM) method]. The purpose of this work was to investigate the effects of passengers and windows on electromagnetic fields (EMF) in aircraft and other vehicles. Comparison of the multimode models with measurements made in a screened room showed that as the electromagnetic losses increased, the transmission between two internal antennas was reduced, and there were fewer turning points in its frequency response. The autocorrelation of this frequency response provided a useful estimate of the composite Q-factor of the resonances and showed that the Q of the chamber was reduced from a value of the order of 10 000 when emptied to 1000 when windows were added and when filled with people to 100. The TLM simulation provided further useful information about the statistical variation of electric field strength with position.
The Performance Evaluation of the Integration of Inertial Navigation System and Global Navigation Satellite System with Analytic Constraints

The integration of GNSS (Global Navigation Satellite System) and INS (Inertial Navigation System) using IMU (Inertial Measurement Unit) is now widely used for MMS (Mobile Mapping System) and navigation applications to seamlessly determine position, velocity and attitude of the mobile platform. With low cost, small size, ligh weight and low power consumtion, the MEMS (Micro-Electro-Mechanical System) IMU and low cost GPS (Global Positioning System) receivers are now the trend in research and using for many applications. However, researchs in the literature indicated that the the performance of the low cost INS/GPS systems is still poor, particularly, in case of GNSS-noise environment. To overcome this problem, this research applies analytic contrains including non-holonomic constraint and zero velocity update in the data fusion engine such as Extended Kalman Filter to improve the performance of the system. The benefit of the proposed method will be demonstrated through experiments and data analysis.
MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival

Francisella tularensis is able to survive and grow within macrophages, a trait that contributes to pathogenesis. Several genes have been identified that are important for intramacrophage survival, including mglA and iglC. F. tularensis is also able to survive within amoebae. It is shown here that F. tularensis mglA and iglC mutant strains are not only defective for survival and replication within the macrophage-like cell line J774, but also within Acanthamoebae castellanii. Moreover, these strains are highly attenuated for virulence in mice, suggesting that a common mechanism underlies intramacrophage and intraamoebae survival and virulence. A 2D gel analysis of cell extracts of wild-type and mglA mutant strains revealed that at least seven prominent proteins were at low levels in the mglA mutant, and one MglA-regulated protein was identified as the IglC protein. RT-PCR analysis demonstrated reduced transcription of iglC and several other known and suspected virulence genes in the mglA mutant. Thus, MglA regulates the transcription of virulence factors of F. tularensis that contribute to intramacrophage and intraamoebae survival.
Predicting Retweeting Behavior Based on BPNN in Emergency Incidents

Emergency incidents can trigger heated discussions on microblogging platforms, and a great number of tweets related to emergency incidents are retweeted by users. Consequently, social media big data related to the emergency incidents is generated from various social media platforms, which can be used to predict users’ retweeting behavior. In this paper, the characteristics of individuals’ retweeting behaviors in emergency incidents are analyzed, and then 11 important characteristics are extracted from recipient characteristics, retweeter characteristics, tweet content characteristics, and external media coverage. A back propagation neural network (BPNN) model called PRBBP is used to predict retweeting behavior in such emergency incidents. Based on PRBBP, an algorithm called PRABP is proposed to predict the number of retweets in emergency incidents. The experiments are performed on a large-scale dataset crawled from Sina weibo. The simulation results show that both the PRBBP model and the PRABP algorithm proposed by this paper have excellent predictive performance.
A Discrete Choice Model of Alcoholism Treatment Location

In this study, a discrete choice model of alcoholism treatment location, with special emphasis on the roles of comorbidities is considered. Three specific questions are addressed: 1) what demographic and health factors have significant impacts on treatment location for both short- and long-term alcoholism and nonalcoholism treatments? ; 2) how does the impact of alcohol dependence differ from the impact of alcohol abuse, on probabilities of short-term or longterm inpatient treatment? ; and 3) what are the impacts of health comorbidities on probabilities of inpatient treatment in the short or long term? A binomial logit model is estimated for short- and long-term alcoholism treatment, as well as for short- and long-term nonalcoholism treatment (which occurs at the same time). The results indicate the importance of comorbidities in predicting treatment location. They also indicate a trend during the 1980s toward increased use of outpatient rather than inpatient treatment.
Improved performance of PSNR metric using SURF saliency map and CSF filter for standard coding H264/AVC: Improved performance of PSNR metric using SURF and CSF

The utilization of human visual system characteristics in measuring the quality of images and video sequences becomes a very important axis of research. The best objective criterion is as close as possible to the judgment of the human being. Our idea is to establish a pretreatment to existing measure with complete reference (PSNR “Peak Signal-to-Noise Ratio”) for the H.264/MPEG-4 (Motion Picture Expert Group) AVC (Advanced Video Coding) standard. We perform a pretreatment using SURF (Speeded Up Robust Features) saliency map and a CSF filter with distance of 500 mm to improve the performance of these metrics. For the evaluation of our proposed model, the database Video subjective “Live” is used to measure the correlation. Performance indicators, namely Pearson (PLCC), the Spearman coefficient (SROCC) and mean squared prediction error (RMSE) indicate that our idea gives better results for the distortion caused by H264 video encoding.
Diabetes, mortality and coronary heart disease in the prospective Dubbo study of Australian elderly.

BACKGROUND A prospective study of Australian elderly living in Dubbo has shown that diabetes is a significant predictor of all-causes mortality and coronary heart disease (CHD). AIM To examine and contrast clinical and socio-demographic predictors of these outcomes in those with and without diabetes. METHODS The data are derived from a community-based sample of subjects 60 years and older followed over 62 months since 1988. Of 1155 men and 1472 women, 9.2% and 6.9% respectively manifested diabetes at baseline, based on history or fasting hyperglycaemia. RESULTS In the presence of diabetes, all-causes mortality was increased twofold in both sexes, CHD incidence was increased twofold in men and threefold in women, stroke incidence was increased twofold in women but little changed in men. Proportional hazards models were derived separately for persons with and without diabetes and risk factors differentially predictive in diabetes were sought. Significant predictors of death in diabetes were old age and current smoking. Those factors differentially predictive were 'being married' (Relative Risk [RR] 1.60 with diabetes and 0.69 without diabetes) and higher body mass index (BMI) (RR 1.03 with diabetes and 0.79 without diabetes). Significant predictors of CHD in diabetes were old age, prior CHD, severe hypertension, low HDL cholesterol and self-rated health. Those factors differentially predictive were higher body mass index (RR 1.14 vs 0.83) and physical disability (RR 0.69 vs 1.55). Differential predictions with regard to BMI may relate in part to excess CHD and mortality at low BMI in non-diabetic subjects. CONCLUSION The vascular disease burden of diabetes in the elderly has been confirmed, especially in women. A number of conventional risk factors are contributing to this burden and may be amenable to treatment.
Assessment of azinphosmethyl exposure in California peach harvest workers.

We compared measurements of urinary alkylphosphate metabolites and oxime-induced reactivation of plasma cholinesterase (P-ChE) and erythrocyte acetylcholinesterase (RBC-AChE) with measurements of foliar residues, skin and clothing contamination, and P-ChE and RBC-AChE activities among 20 Northern California peach orchard workers exposed to the organophosphate agent azinphosmethyl (Guthion). Subjects entered orchards treated 30 d previously with azinphosmethyl and worked 21 d in treated fields during the ensuing 6 wk. Dislodgeable foliar residues ranged from 0.32-0.96 micrograms/cm2. Median reduction in RBC-AChE activity was 7% (p < .001) over the initial 3-d period of exposure and 19% (p < .01) over the 6-wk season. Urinary metabolites were the most sensitive indicator of recent exposure and correlated moderately with dermal and clothing levels (rs = +0.31-(+)0.55); urinary metabolites correlated well with RBC-AChE drawn 3 d after exposure began (rs = -0.77). No significant oxime-induced reactivation was found.
Ultrastructural changes in the edematous central nervous system. 3. Edema in shark brain.

IN THE course of our electron microscopic investigation of various types of experimental edemas of the brain, 1,2 the complexity of the central nervous system (CNS) of mammals and the variety of its cells became a limiting factor in evaluating the significance of some of the observations. It was felt that a primitive brain, yet, a brain that contained all the essential structural elements of the nervous system of mammals, namely, nerve cells, glia cells, myelin sheaths, and an intracerebral network of blood vessels, would lend itself very well to studying edema formation in a relatively simple system. The criteria imposed by us excluded the use of invertebrates or such primitive vertebrates as cyclostomata because of the dissimilarity of their blood supply to the CNS and the lack of myelin sheaths. 3,4 This latter structure was essential to the study of cerebral edema because most forms of brain swelling are
LHCb Preshower(PS) and Scintillating Pad Detector (SPD): Commissioning, calibration, and monitoring

The calorimeter system of the LHCb experiment comprises in front to the electromagnetic and hadronic calorimeters a double detector, aimed at tagging the electric charge and the electromagnetic nature of the calorimeter clusters for the first level of trigger. It consists of two planes of scintillating pads separated by a 2.5 radiation lengths lead sheet. The first scintillating plane is the SPD. The second plane and the lead form the Preshower. Their design and construction are recalled. Their performance and calibration strategies are discussed and illustrated by recent results.
The Fate of Plates and Screws after Facial Fracture Reconstruction

Rigid plate and screw fixation is the mainstay of treatment for complex fractures of the facial skeleton. Complications of plate and screw fixation include prominence, infection, exposure, and migration. Five hundred and seven patients undergoing plate and screw fixation for facial fractures (1112 fractures) from 1983 to 1988 were followed for complications. Sixty-one patients (12 percent) required hardware removal. The location on the facial skeleton influenced symptoms and the rate of hardware removal. Infection and exposure may be decreased with antiseptic irrigations, avoiding mucosal damage, attention to proper mucosal closure, and correct placement of plates. Prominence may be decreased by the use of microplates in teh supraorbital, frontal, and nasoorbital-ethmoid locations. (Plast. Reconstr. Surg. 90: 568, 1992.)
Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1

The induction of gene transcription in response to gamma interferon is impaired in mononuclear phagocytes infected with Leishmania donovani, and the mechanisms involved are not fully understood. The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases, including the Janus kinases Jak1 and Jak2, leading to tyrosine phosphorylation of the transcription factor Stat1. To investigate the mechanisms accounting for the impaired responses to gamma interferon, a model system for examining overall changes in protein tyrosine phosphorylation, activation of Jak1 and Jak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate-differentiated U-937 cells. Analysis of whole-cell lysates by antiphosphotyrosine immunoblotting showed that incubation with gamma interferon brought about specific increases in phosphotyrosine labeling of several proteins. Increased labeling of these proteins occurred to similar extents in control cells and in cells that had been infected with L. donovani for 16 h. Jak1, Jak2, and Stat1 were immunoprecipitated from control and interferon-treated cells, and tyrosine phosphorylation of these proteins, detected by antiphosphotyrosine immunoblotting was used to measured their activation. Tyrosine phosphorylation of Jak1, Jak2, and Stat1 increased markedly, in a dose-dependent manner, in U-937 cells incubated with gamma interferon. In contrast, in cells infected with L. donovani, tyrosine phosphorylation of Jak1, Jak2, and Stat1 was markedly impaired. This effect was dependent upon the duration of exposure to L. donovani and was maximal and complete at 16 h. Results similar to those observed with U-937 cells were also obtained with human peripheral blood monocytes. These findings indicate that infection of human mononuclear phagocytes with L. donovani leads to impaired gamma interferon-mediated tyrosine phosphorylation and selective effects on the Jak-Stat1 pathway. Unresponsiveness to gamma interferon for activation of this pathway may explain impaired transcriptional responses in leishmania-infected cells.
THE PAINLESSNESS OF THE LONG DISTANCE RUNNER

Statistical probabilities (one tailed) were determined by the signs test. " The results, summarized in Table 1, indicate that the post-run "pain-times" at all of the intensities determined (onset, 20%. 40%, 60%, 80% and 100%) were significantly longer (P< 0.05) than the equivalent pre-run measurements. Naloxone was without effect on these measures. On the other hand, the "pain-times" determined at the equivalent time as "post-run" for the two "non-run" control occasions were, in eight of the 12 measurements (from onset to 100%), less than the equivalent "pain-times" in the pre-run determinations. This is in accord with our previous experience with the technique. " For all runs, the mean of the pre-run times to maximum tolerated pain was 263 ±4 seconds (x ±SEM) while that for the post-run time was 376 ± 16 seconds.
Lengths and topology of alveolar septal borders.

To clarify the mechanics of alveolar parenchyma, we undertook a stereological and topological study in perfusion-fixed canine lungs of the borders of alveolar septa. We defined the principal borders as those along which one septum 1) joins two others (J), 2) joins one other at a distinct angle (B), or 3) joins no other structure (E). E and B borders are invariably reinforced with heavy connective tissue cables; J borders are not. Relative net lengths, determined from the number of traces per section area, were J, 45%; E, 19%; and B, 25%. These were remarkably constant over 10 canine lobes (5 animals, 4 volumes). Parenchyma, then, departs from the simple models that comprise only Js and Es. Bs are important; their net length exceeds that of Es. With lobe deflation, E shortened somewhat more than required to maintain geometric similarity, suggesting that the alveolar duct contracted disproportionately. A three-dimensional reconstruction was made from serial sections, and individual border segments were followed through the reconstruction. Typical lengths of individual J, B, and E borders were nearly equal. To characterize how the network of borders were interconnected, we counted the nodes at which they meet by class, e.g., EBE for the meeting of one B, two Es. The most common are JJJJ, 26%; EEEJ, 10%; EBJ, 24%; EBE, 8%; BBJJ, 12%. If parenchyma were constructed only from free-standing entrance rings and septal junctions, only JJJJ and EEEJ would be anticipated. The presence of EBJ, EBE, and BBJJ underscores parenchymal complexity. Only 7% of septa examined were bordered entirely by Js. Connective tissue cables were not confined to the alveolar duct's lumen but often extended to the primary septa at the periphery of the ductal unit. They rarely linked adjacent alveolar ducts; only 1 in 200 cable segments crossed from one duct to another. These observations support the concept that the parenchyma is an elastic network, characterized in part by a serial mechanical linkage from connective tissue cable to septal membrane to cable again.
Layer by layer: A multidimensional approach to online social profiles

Online social networks allow users to socialise with others, reveal a lot about themselves by sharing their personal preferences in a freely way, and also construct and manage their identities via self-presentation. This network of interests is often represented in a single network and it is difficult for organisations to obtain insights from it, or even measuring the impact of their online content. By dividing an ‘unidimensional’ interest network into individual layers of networks, it is possible to obtain insights about the impact of content, user interests, or even understand patterns of usage. This paper contains a model proposition for a multidimensional network of interests based on online interest networks and the online behaviour that is driven by personality characteristics.
Eminence-Based Medicine versus Evidence-Based Medicine: It's Okay for 12-Year-Old Pitchers to Throw Curveballs; It's the Pitch Count that Matters

Abstract Working from a prior investigation, we sought to determine the validity of the claim: “It's okay for 12-year-old pitchers to throw curveballs; it's the pitch count that matters. ” Our previous expert opinion survey demonstrated that this statement was most probably false. The purpose of this report was to investigate the validity of this statement, and to determine if our sports medicine experts “got it right. ” Using the most current sports medicine literature, this statement was critically examined so that an evidence-based opinion could be given and compared with the results of our prior study.
A Fully Automatic Player Detection Method Based on One-Class SVM

Player detection is an important part in sports video analysis. Over the past few years, several learning based detection methods using various supervised two-class techniques have been presented. Although satisfactory results can be obtained, a lot of manual labor is needed to construct the training set. To overcome this drawback, this letter proposes a player detection method based on one-class SVM (OCSVM) using automatically generated training data. The proposed method is evaluated using several video clips captured from World Cup 2010, and experimental results show that our approach achieves a high detection rate while keeping the training set construction’s cost low. key words: player detection, one-class SVM, decision-making, broadcast sports video analysis
An open study of dehydroepiandrosterone in systemic lupus erythematosus.

OBJECTIVE To determine if dehydroepiandrosterone (DHEA) has clinical benefits in patients with systemic lupus erythematosus (SLE). METHODS Ten female patients with mild to moderate SLE and various disease manifestations were given DHEA (200 mg/day orally) for 3-6 months. The patients were given other medications as clinically indicated, and followed with respect to overall disease activity and specific outcome parameters. RESULTS After 3-6 months of DHEA treatment, indices for overall SLE activity including the SLEDAI (SLE Disease Activity Index) score and physician's overall assessment were improved, and corticosteroid requirements were decreased. Of 3 patients with significant proteinuria, 2 showed marked and 1 modest reductions in protein excretion. DHEA was well tolerated, the only frequently noted side effect being mild acneiform dermatitis. CONCLUSION DHEA shows promise as a new therapeutic agent for the treatment of mild to moderate SLE. Further studies of DHEA in the treatment of SLE are warranted.