Miracle-dz/UniFAR-FTUs huggingface dataset:
Multirésistance aux biothérapies moléculaires dans la polyarthrite rhumatoïde : étude observationnelle et rétrospective chez 385 patients

Malgre un large choix de biotherapies moleculaires dans le traitement de la polyarthrite rhumatoide (PR), certains patients echouent a de multiples lignes. L’objectif de notre etude est de decrire les caracteristiques de ces patients et d’etablir des facteurs associes a la multiresistance aux biotherapies dans la PR. Patients et Methodes Dans cette etude observationnelle, retrospective, parmi la file active de PR du service de rhumatologie du CHU de ROUEN, sous biotherapie entre janvier 2007 et juillet 2017, ont ete identifies les patients multiresistants, definis par l’echec, primaire ou secondaire, d’au moins 2 molecules (faute de definition consensuelle). Leurs caracteristiques cliniques et paracliniques a l’initiation de la premiere biotherapie ont ete recueillies grâce a leur suivi standardise, et comparees a celles de patients « repondeurs » ayant recu une unique biotherapie efficace pendant au moins 10 ans. Resultats Notre file active comptait 385 patients. Ont ete inclus respectivement 53 et 50 patients dans les groupes multiresistants et repondeurs. L’âge moyen des patients multiresistants a l’initiation de la biotherapie etait de 50,3 ans (±13,2 ans), avec un sex ratio de 2,8 femmes/1 homme. Ils presentaient des PR erosives (77,4%), facteur rhumatoide et anticorps antipeptides cycliques citrullines positifs (73,6%), fortement actives (Disease Activity Score 28 CRP moyen 5,36±1,28 ; nombre d’articulations douloureuses et gonflees medians 8/28 ; echelle visuelle analogique activite mediane 70/100, CRP mediane 21 mg/L), et au fort retentissement fonctionnel (Health Assessment Questionnaire median : 1,500). L’âge de debut de la PR etait significativement plus tardif chez les patients multiresistants que chez les patients repondeurs (43±14,2 ans versus 37,9±10,7 ans ; p=0,042). Aucune caracteristique demographique, clinique et paraclinique ne differait significativement entre les deux groupes. Conclusion Hormis l’âge tardif de debut de la maladie, notre etude n’a pas permis d’identifier de facteurs associes a la multiresistance aux biotherapies moleculaires dans la PR. Peu etudiee, elle reste l’un des defis dans la prise en charge de la PR.
Hybrid Genetic Algorithms and Simulated Annealing for Multi-trip Vehicle Routing Problem with Time Windows

Vehicle routing problem with time windows (VRPTW) is one of NP-hard problem. Multi-trip is approach to solve the VRPTW that looking trip scheduling for gets best result. Even though there are various algorithms for the problem, there is opportunity to improve the existing algorithms in order gaining a better result. In this research, genetic algoritm is hybridized with simulated annealing algoritm to solve the problem. Genetic algoritm is employed to explore global search area and simulated annealing is employed to exploit local search area. Four combination types of genetic algorithm and simulated annealing (GA-SA) are tested to get the best solution. The computational experiment shows that GA-SA1 and GA-SA4 can produced the most optimal fitness average values with each value was 1.0888 and 1.0887. However GA-SA4 can found the best fitness chromosome faster than GA-SA1.
Long-Term Effectiveness of Antistripping Additives

Hydrated lime and liquid antistripping agents are often used as additives in asphalt mixes to improve their resistance to moisture damage. Most laboratory studies have evaluated the effectiveness of these additives on the basis of a short-period intensive moisture conditioning procedure, usually a freeze–thaw cycle. Whether this short-term conditioning sufficiently simulates the actual field conditions is unknown. Questions have arisen about the performance of asphalt mixes exposed to moisture for a long period and the effectiveness of antistripping additives after long-term conditioning. This research was conducted in the laboratory to answer these questions to some extent by two test methods: the indirect tensile strength ratio test and the flexural beam fatigue test. A moisture-sensitive mix was treated with the hydrated lime and liquid antistripping agents, saturated by vacuum, and conditioned in a humid environment for a period of up to 1 year. Mix properties were measured and analyzed every 4 months. It was found that most of the detrimental effects of moisture occurred in the first 4 months, and the reduction of strength or stiffness in the late stages became small. Both tests revealed that the antistripping additives were effective even after 1 year of moisture conditioning. Equivalency between the short-term intensive conditioning and the long-term mild conditioning was also found in this study.
Geography of Public Participation

How effective are public involvement programs in reaching a representative and sufficient sampling of public input for a planning study? While evaluations of public involvement programs are traditionally qualitative, this paper shows how geographic information systems (GIS) can provide an appropriate and productive means of quantitatively evaluating the effectiveness of an agency's outreach program. This study used both mailing list and comment data from the Dulles Corridor Rapid Transit Project Environmental Impact Statement of the Virginia Department of Rail and Public Transportation to evaluate the agency's outreach program. The data were analyzed to determine the project's effectiveness in informing and receiving feedback from potential stakeholders. The analysis showed that 50% of the mailing list members lived within 1/2 mi of the proposed project. “Inclusion rates” were calculated, with household participation rates in census block groups near the project ranging from 0 to 82%. The Tysons Corner segment of the project, where the proposed rail line would be closest to residences, on average had the highest inclusion rates, with 16.5% of households within 1/2 mi of the proposed stations participating. Of the six block groups meeting the project's environmental justice thresholds, half had an inclusion rate below 5%. Analysis of commenters showed that those closest to the project were most likely to comment on the study and to express opposition to the project in their comments. This study reinforces many traditional stereotypes in public participation, but, more important, it demonstrates a method by which deficiencies in outreach efforts can be identified and measures taken to improve participation. By using the GIS-generated maps, agencies can readily identify geographic areas that may be affected by the project, yet have low participation rates, and use this information to develop additional outreach tools to target these populations.
PLANT INVASIONS: THEIR THREATS IN AN IRISH CONTEXT

Abstract:Although there are some notable exceptions, introduced plant species tend not to receive the public and media attention that their animal counterparts do; however, the impacts they have on the environments they invade can be equally, and sometimes more, dramatic. This article presents a short overview of the main ecological and economic impacts that alien plants can have on invaded regions, with particular reference to Ireland. In terms of biological impacts, invasive alien plants may affect the ecology of native species, the composition of biological communities and, in turn, ecosystem processes. In addition, because human-mediated introduction of new species can remove geographic barriers, gene flow between formerly separated species can occur. This can potentially lead to the loss of native genotypes through hybridisation and introgression. However, the impacts of invasive alien plants on native biodiversity and ecosystems are difficult to assess, and are often species- and context-specific, making it almost impossible to make general statements. Economically, invasive alien plants can have impacts on the delivery of ecological goods and services, and can be costly in terms of management and control. Conservative estimates of the cost of invasive alien plants at the European scale run to several billion euro per year, but no assessment has been made specifically for Ireland. Although some invasive alien plants may be directly hazardous to human health, it is their indirect effect on native biodiversity and local economies that are likely to cause most harm to humans. Finally, this paper provides a summary of current and potential Irish invaders and discusses the problems associated with predicting which species will be the next invasive aliens.
Tolerance of embryogenic suspension cultures from two Phragmites communis (reed) ecotypes to salt: Changes of respiration pathway

In the present work, an intensive tolerance to high salt stress of embryogenic suspension cultures from two reed (Phragmites communis Trin.) ecotypes, dune reed and swamp reed, was found and studied. The dune reed was more resistant than the swamp reed to salt. Aiming at better understanding the characteristic tolerance to salt stress in reed plants, changes of respiration and respiratory pathways in both reed suspension cultures exposed to 50-800 mM NaCl stress were measured and analyzed. The results demonstrated that the respiration rates of both reed cultures increase significantly during the 50-400 mM NaCl treatment. Inhibition tests with cyanide and salicylhydroxamic acid showed that the increasing respiration rate resulted from high operation of the cytochrome pathway in the dune reed, and cooperation of the cytochrome pathway and an alternative pathway in the swamp reed. The respiration rates of both reed cultures decreased dramatically following 800 mM NaCl treatment. The results were due to the l.
RhoB is regulated by hypoxia and modulates metastasis in breast cancer

RhoB is a Rho family GTPase that is highly homologous to RhoA and RhoC. RhoA and RhoC have been shown to promote tumor progression in many cancer types; however, a distinct role for RhoB in cancer has not been delineated. Additionally, several well‐characterized studies have shown that small GTPases such as RhoA, Rac1, and Cdc42 are induced in vitro under hypoxia, but whether and how hypoxia regulates RhoB in breast cancer remains elusive.
Simulation of mobile edge-cloud applications using Mininet-WiFi

The ubiquity of mobile devices led to the consideration of mobile edge clouds (MECs), networks formed by devices in close proximity without infrastructural support, or at most optionally complemented by cloudlets, lightweight servers serving small areas. MECs empower novel crowd-sourcing, proximity-aware applications, where computation and communication mostly occur at the edge of network, without depending on infrastructural communications and cloud services. Simulation approaches are required to validate MEC applications reliably and at scale, as ﬁeld experiments can be onerous and hard to replicate, in regard to factors such as the number of nodes, geographical area, network setup, or mobility patterns. We outline our approach for the simulation of MEC applications making use of the Mininet-WiFi platform, taking into account real-world application scenarios from the Hyrax project.
Equalization in chaos-based communication systems using kernel adaptive filtering

Chaos-based communication systems have attracted attention of researchers in academy and industry in the last decades. A particular family of such systems has as basic idea to use the transmitted message to modify a known nonlinear chaotic signal generator (CSG). In the receiver, the knowledge of the employed nonlinear CSG in conjunction with chaotic synchronization permits to recover the original message. These systems are an alternative for spread spectrum communication with a possible increase in the security in the physical layer, since it is necessary to perfectly know the CSG in the receiver to decode the message. However, the lack of robustness of chaotic synchronization in relation to channel noise and intersymbol interference still poses a barrier for their practical use. The problem of equalization for such systems have been tackled for a while, and algorithms based on the normalized least-mean squares have presented auspicious results for linear channels. For nonlinear channels, Kernel Adaptive Filters (KAFs) have been used since they are able to solve nonlinear problems implicitly projecting the input vector into a larger dimension space, where they can be linearly solved. Therefore, in this paper, we propose the use of KAFs with two purposes: to equalize linear and nonlinear channels and, at the same time, decode the message without knowledge of the CSG in the receiver. Simulation results show that the proposed solution is able to perform these tasks.
Potencial nutricional das algas vermelhas Hypnea musciformis e Solieria filiformis: Análises da composição centesimal

Resumo: Algas sao fontes de proteinas, vitaminas e sais minerais e fazem parte da alimentacao humana. Existem milhares de variedades de algas marinhas, cada especie de alga marinha e unica, na sua composicao, forma, sabor e textura. Embora nem todas as algas existentes sejam consumidas, uma grande parte ja e incluida na alimentacao humana. O objetivo do presente estudo foi obter dados sobre a composicao nutricional de algas do filo Rhodophyta, Hypnea musciformis e Solieria filiformis, ambas encontradas no litoral cearense, visando a avaliacao do seu potencial para uso como ingredientes alimentares. As analises de Umidade, Cinzas e Proteinas foram realizadas pelo metodo de Kjeldahl e Lipideos pelo metodo de Bling Day. Os carboidratos totais foram calculados por diferenca. Foram realizados em triplicata e calculada a media.Os resultados das analises para algas vermelhas H. musciformis e S. filiformis, respectivamente, foram umidade: 14,17% e 15,06 %; cinzas: 14,14% e 15,12%; proteina: 17,12% e 20,31%; lipideos: 0,33% e 0,33% e carboidratos totais: 54,24% e 49,18%. Ambas, algas vermelhas exibiram um amplo aspecto de composicoes nutricionais que os tornam excelentes candidatos para uma alimentacao adequada a nutricao humana.
Effect of Chlorocholine Chloride and Triazoles – Tebuconazole and Flusilazole on Winter Oilseed Rape (Brassica Napus Var. Oleifera L.) in Response to the Application Term and Sowing Density

Winter oilseed rape is strongly responsive to changes in the plant density. Any change in plant density significantly affects the morphological characteristics and yield of the crop. In addition, plant growth habit can be modified by the use of plant growth regulators. Apart from plant growth regulators like eg. chlorocholine chloride some triazoles have dual properties (fungicide and plant growth regula- tor) eg. tebuconazole. The trials were carried out in the years 2006-2008 at the Institute of Plant Protection - National Research Institute in Poznan (Poland). The treatments consisted of chlorocholine chloride, tebuconazole and flusilazole applied in spring at the growth stage BBCH 30 and BBCH 50 of winter oilseed rape. The field trials were conducted with two sowing densities of winter oilseed rape: 60 seeds/ m2 and 120 seeds/m2. The vegetation seasons varied according to the weather conditions, and the second testing year was characterised by drought in May and June. In the experiments plant height, SPAD units, number of siliques per plant, seed number per silique, weight of thousand seeds, yield, protein and fat content in the seeds were estimated. The increase of silique numbers per plant appeared only at the lower sowing density as a result of the application of tebuconazole or a mixture of tebuconazole with CCC. Flusilazole had a positive impact on seed number per silique. At both sowing densities, changes in the weight of a thousand seeds under the influence of the test preparations, were observed only in that year which had wet weather conditions. A more favourable effect of the test substances on the weight of a thou- sand seeds was obtained at the lower sowing density. All the tested substances positively affected SPAD unit values at the lower sowing density. At the higher sowing density, SPAD unit values increased after the application of flusilazole, and after a mixture of CCC + tebuco- nazole. The tested substances had a positive impact on plant yield but they did not affect the protein and fat content in oilseed rape seeds.
Path Loss Model in Crowded Indoor Environments Considering Multiple Human Body Shadowing of Multipath at 4.7 GHz and 66.5 GHz

In this paper, we report the performance of our propagation loss estimation model in a congested environment, and we show an estimation formula that easily derives the estimation result. We obtained propagation loss characteristics in the 4.7 GHz and 66.5 GHz bands around Kamiooka Station’s main ticket gate, which is a congested indoor environment. The RMS error of the calculation results of our propagation loss estimation formula and the measured value improved by about 1 dB on average compared with the free space loss and the RMS error of the measured value. The propagation loss estimation formula we propose can estimate propagation loss characteristics with high accuracy even indoors.
Fatigue is a behavioural response in respirometer- confined smallmouth bass

Fatigue in respirometer-confined smallmouth bass Micropterus dolomieu was confirmed as being largely a behavioural response, and not brought about by depletion of anaerobic fuel stores. While data collected from these fish did not preclude the possibility that the behavioural response was triggered when some physiological threshold was exceeded, locomotory gait transition patterns in confined fish exposed to increasing water velocities support an alternate hypothesis. This is that fatigue is a behavioural decision made at (or near) the gait transition swimming speed, in an effort to avoid activity that, by virtue of the limited space in a typical respirometer, is energetically inefficient and biomechanically difficult.
Assessing Public Response to Freeway Roadsides

Social science methods can be used to assess how the public values context-sensitive solutions. The roadside landscape is a public lands resource that has many functions and provides many benefits. Diverse stakeholders may have varied expectations for roadside design. The urban forest is often a contested component of the urban roadside. Two research surveys based on landscape assessment literature were used to assess and quantify public preferences and perceptions with regard to trees in highspeed and freeway roadsides. One photo questionnaire was distributed in urban areas nationally and the other in Washington State. To elicit public attitudes about visual quality and community image, each survey included design visualizations constructed with digitally edited photographs. Research results were consistent across both studies. Respondents judged images with increasing amounts of roadside vegetation, including trees, to have a higher amenity value. The presence of more extensive community greening was associated with positive consumer inferences and greater willingness to pay for goods and services. There was little variation in responses across respondent demographics. Results provide an empirical basis for flexible highway design and promote planning options for roadside urban forests that address multiple stakeholder interests.
Activities of SOD and the ascorbate-glutathione cycle enzymes in subcellular compartments in leaves and roots of the cultivated tomato and its wild salt-tolerant relative Lycopersicon pennellii

The activities of the ascorbate-glutathione cycle enzymes ascorbate peroxidase (APX), monodehydroascorbate reductase (MDHAR), dehydroascorbate reductase (DHAR) and glutathione reductase (GR) and SOD were studied in cell organelles of the cultivated tomato Lycopersicon esculentum (M82) and its wild salt-tolerant related species Lycopersicon pennellii (Lpa). All four enzymes of the ascorbate-glutathione cycle were present in chloroplasts/plastids, mitochondria and peroxisomes of leaf and root cells of both tomato species. In all leaf and root organelles of both species, the activity of MDHAR was similar to, or higher than, that of APX, while the activity of DHAR was one order of magnitude lower than that of MDHAR. Based on these results, it is suggested that in the organelles of both tomato species, ascorbate is regenerated mainly by MDHAR. In both tomato species, GR activity, and to a lesser extent DHAR activity, was found to reside in the soluble fraction of all leaf and root cell organelles, while APX and MDHAR activities were distributed between the membrane and soluble fractions. A higher SOD to APX activity ratio in all Lpa organelles was the major difference between the two tomato species. It is possible that this higher ratio contributes to the inherently better protection of Lpa from salt stress, as was previously reported.
Editorial

In this special issue of the Journal of Health Management, titled ‘Organising the Disorganised: A Cross-cultural Outlook of NGOs’, aspects of the challenge for NGOs to influence development policy have been examined. As actors in development, NGOs are strongly shaped by the wider changes taking place in the environment. Yet they must find ways to contribute to the ultimate direction and form that such changes take as they engage in acts of resistance and negotiation. The main premise of the issue is against this backdrop of change—the questioning of deep-rooted beliefs and ideologies, the signs of a new pragmatism in NGOs’ need, and their roles and relevance. One part of this search for relevance is to be found in the ability of NGOs and their relative relationship with donors, and Northern perspectives on Southern NGOs. Various articles present different perspectives on these global changes, taking NGOs as the entry point for developing new understandings, and exploring how NGOs themselves are adapting, changing and rising to the challenge of working and finding a voice within increasingly complex and unpredictable environments. At a more theoretical level, Sadhvi Dar explores the contribution to the under-researched but growing literature related to the organisational theory of non-governmental organisations. Many developmental academics and practitioners have highlighted the imposition of Northern ideas and values on Southern NGOs as inherently colonial, patronising and leading to minimal grassroots autonomy. While acknowledging this, Dar analyses the diffusion of Northern managerialism on Southern ways of working with special reference to how Southern NGOs are pressured to exude a cohesive, uniform and positive organisational identity in order to work in partnership with their donors. In doing so, the analysis points to the concept of organisational identity itself being a construct of Northern ideas of management and, there-fore, not applicable universally. Dar suggests that fissures and