Miracle-dz/UniFAR-FTUs huggingface dataset:
Time-based risk assessment after myocardial infarction . Implications for timing of discharge and applications to medical decision-making

Aims We evaluated timing of adverse cardiac events after thrombolysis to guide length of stay after ST-segment elevation myocardial infarction. Methods and Results Kaplan–Meier survival curves described timing of major postinfarction complications in 41 021 fibrinolytic-treated patients in GUSTO-I. Using model-fitting, these data were best explained by a mixed-exponential survival model: an acute curve describing most adverse events and a chronic curve describing a lower background rate. We replicated this strategy in 15 059 fibrinolytic-treated patients in GUSTO-III. From the relation between time and events described by the model’s acute curve in GUSTO-III, we proposed times for hospital discharge. The acute curve explained 97% of deaths and 68%–96% of various event composites. Of complications within 10 days, 90% of deaths and 70% of acute curve death, stroke, shock, heart failure, or reinfarction occurred by 24 h. By 2.7 days, 95% of deaths, stroke, shock, heart failure, or reinfarction occurred. Most major ventricular arrhythmias occurred within 24 h, after which the hazard curve was flat. Conclusions Mixed-exponential survival modelling describes timing of post-infarction complications and supports discharge 4 days after uncomplicated infarction. Such time-based risk assessment could guide decision-making in other settings in which randomized studies are impractical. © 2003 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.
Quantitative Feedback Design for a Benchmark Quadruple-Tank Process

In this paper level control for a quadruple-tank process with variable nonlinear zero dynamics is considered. This provides a nice benchmark problem that illustrates some of the challenges posed by complex interconnected systems for linear design paradigms. A quantitative feedback theory (QFT) methodology is used to provide robust control of the water level in the lower two tanks. The linear design is validated on the nonlinear system model.
Mechanism and Kinetics of Aluminum Nitride Powder Degradation in Moist Air

Aluminum nitride (AlN) powders manufactured via three major commercial processes, namely, chemical vapor deposition from triethyl aluminum, carbothermal reduction and nitridation of alumina, and direct nitridation of aluminum, were exposed to moist air at room temperature to investigate the degradation mechanism and kinetics. In the degradation, the powders were initially hydrolyzed to amorphous aluminum oxyhydroxide, which subsequently transformed into mixtures of crystallized aluminum trihydroxide (Al(OH)3) polymorphs, i.e., bayerite, nordstrandite, and gibbsite, forming agglomerates around the unreacted AlN. The data were fitted by using the unreacted-core model. Three stages were found in the degradation: the stage of an induction period at the beginning, followed by a stage of fast hydrolysis with the chemical reaction being rate controlling, and finally, with gradual closing of pores in the structure of Al(OH)3 around AlN, changing to a stage of slow hydrolysis that was controlled by mass diffusion through Al(OH)3. The existence of an induction period was attributed to slow hydrolysis of the surface oxide/oxyhydroxide layer. The powder produced by the carbothermal process showed the longest induction period, which was attributed to its surface structure being different from other powders.
Misframed Proteins and Neurodegeneration: A Novel View on Alzheimer’s and Parkinson’s Diseases

Sporadic forms of Alzheimer’s and Parkinson’s diseases are the most frequent forms of their kind. Together with Huntington’s disease, they belong to the so called ‘conformational diseases’ as they share a common feature in the accumulation of insoluble protein deposits. In this review, we focus on the significance of the ubiquitin-proteasome system in conformational diseases and the possible consequences due to the accumulation of aberrant proteins. In all forms of Alzheimer’s and Huntington’s diseases, but not in Parkinson’s disease, we have shown the presence of misframed proteins such as misframed ubiquitin (UBB+1) of which we have determined the functional relevance in vitro and in vivo.Misframed proteins are the result of the inaccurate transcription of monotonic sequences in the genome and their subsequent translation. This process has been called ‘molecular misreading’. In the present review, we will discuss the present state of the art with regard to UBB+1 and amyloid precursor protein APP+1.
Recovery of central and peripheral neuromuscular fatigue after exercise.

Sustained physical exercise leads to a reduced capacity to produce voluntary force that typically outlasts the exercise bout. This "fatigue" can be due both to impaired muscle function, termed "peripheral fatigue," and a reduction in the capacity of the central nervous system to activate muscles, termed "central fatigue. " In this review we consider the factors that determine the recovery of voluntary force generating capacity after various types of exercise. After brief, high-intensity exercise there is typically a rapid restitution of force that is due to recovery of central fatigue (typically within 2 min) and aspects of peripheral fatigue associated with excitation-contraction coupling and reperfusion of muscles (typically within 3-5 min). Complete recovery of muscle function may be incomplete for some hours, however, due to prolonged impairment in intracellular Ca2+ release or sensitivity. After low-intensity exercise of long duration, voluntary force typically shows rapid, partial, recovery within the first few minutes, due largely to recovery of the central, neural component. However, the ability to voluntarily activate muscles may not recover completely within 30 min after exercise. Recovery of peripheral fatigue contributes comparatively little to the fast initial force restitution and is typically incomplete for at least 20-30 min. Work remains to identify what factors underlie the prolonged central fatigue that usually accompanies long-duration single joint and locomotor exercise and to document how the time course of neuromuscular recovery is affected by exercise intensity and duration in locomotor exercise. Such information could be useful to enhance rehabilitation and sports performance.
Thrombus Aspiration in ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis: Thrombectomy Trialists Collaboration.

BACKGROUND Thrombus aspiration during percutaneous coronary intervention (PCI) for the treatment of ST-segment-elevation myocardial infarction (STEMI) has been widely used; however, recent trials have questioned its value and safety. In this meta-analysis, we, the trial investigators, aimed to pool the individual patient data from these trials to determine the benefits and risks of thrombus aspiration during PCI in patients with ST-segment-elevation myocardial infarction. METHODS Included were large (n≥1000), randomized, controlled trials comparing manual thrombectomy and PCI alone in patients with ST-segment-elevation myocardial infarction. Individual patient data were provided by the leadership of each trial. The prespecified primary efficacy outcome was cardiovascular mortality within 30 days, and the primary safety outcome was stroke or transient ischemic attack within 30 days. RESULTS The 3 eligible randomized trials (TAPAS [Thrombus Aspiration During Percutaneous Coronary Intervention in Acute Myocardial Infarction], TASTE [Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia], and TOTAL [Trial of Routine Aspiration Thrombectomy With PCI Versus PCI Alone in Patients With STEMI]) enrolled 19 047 patients, of whom 18 306 underwent PCI and were included in the primary analysis. Cardiovascular death at 30 days occurred in 221 of 9155 patients (2.4%) randomized to thrombus aspiration and 262 of 9151 (2.9%) randomized to PCI alone (hazard ratio, 0.84; 95% confidence interval, 0.70-1.01; P=0.06). Stroke or transient ischemic attack occurred in 66 (0.8%) randomized to thrombus aspiration and 46 (0.5%) randomized to PCI alone (odds ratio, 1.43; 95% confidence interval, 0.98-2.10; P=0.06). There were no significant differences in recurrent myocardial infarction, stent thrombosis, heart failure, or target vessel revascularization. In the subgroup with high thrombus burden (TIMI [Thrombolysis in Myocardial Infarction] thrombus grade ≥3), thrombus aspiration was associated with fewer cardiovascular deaths (170 [2.5%] versus 205 [3.1%]; hazard ratio, 0.80; 95% confidence interval, 0.65-0.98; P=0.03) and with more strokes or transient ischemic attacks (55 [0.9%] versus 34 [0.5%]; odds ratio, 1.56; 95% confidence interval, 1.02-2.42, P=0.04). However, the interaction P values were 0.32 and 0.34, respectively. CONCLUSIONS Routine thrombus aspiration during PCI for ST-segment-elevation myocardial infarction did not improve clinical outcomes. In the high thrombus burden group, the trends toward reduced cardiovascular death and increased stroke or transient ischemic attack provide a rationale for future trials of improved thrombus aspiration technologies in this high-risk subgroup. CLINICAL TRIAL REGISTRATION URLs: http://www.ClinicalTrials. gov http://www.crd. york.ac. uk/prospero/. Unique identifiers: NCT02552407 and CRD42015025936.
Firm’s operant resources and service value - A customer perspective in health care service

This study aims to examine how a customer’s perception of a firm’s operant resources (representational, cultural and social resources) affects the service value in a highly interaction service context. An empirical analysis was conducted on 263 patients in health care service in Vietnam. The results show that firm’s operant resources as viewed by customers have a significant impact on perceived service value. Of which, the cultural resource has the strongest weight on customer perceived value. Discussions and managerial implications have been presented accordingly.
Is Economical and Social Development Really Linked with the Shift of Labour from Secondary to Tertiary Sector? Evidence from the Italian Case

In the present paper, first, we have carried out a study about regional deprivation in Italy and tested it with a variable test (in this case, life expectancy at birth) to estimate its goodness. RDI index is linked with life expectancy at birth about 60%. Then we have divided Italian Regions into five different classes, from the “best” (less deprived) to the “worst” (much deprived) one. In each group we have examined the working population in every sector and the share of labourers in primary, secondary and tertiary sector, in order to verify the usual argument according to which growth and socio-economic development go with the boost of tertiary. The tertiary sector is determined according to ISTAT definition, which includes public administration. However, in a further step of our analysis we separate private from public tertiary. The evolution towards the advanced “post-industrial” society is apparently proved wrong in this case.
“Last-chance” sales: what makes them credible?

This paper analyzes the firms’ standard practice of announcing clearance or “last-chance” sales, namely advertising that a particular product is not going to be available in the market anymore. In the context of a two-period signaling game, prices and advertising decisions of firms are analyzed. Then, the set of separating and pooling equilibria is characterized, so that the above usual advertising techniques can be better understood as equilibria of this model for certain parameter values. In particular, this paper shows that, when the firm which continues in the business knows that few of their current customers will come back in future periods, the set of separating equilibria shrinks. That is, fewer future prospects induce all types of firms to compete for current consumers, leading to pooling equilibria in which all firms announce a “last-chance” sale, even if some of them know they will remain in the industry next period. Clasificación JEL: L12, D82.
Surfactant‐Free, Self‐Assembled PVA‐Iron Oxide/Silica Core–Shell Nanocarriers for Highly Sensitive, Magnetically Controlled Drug Release and Ultrahigh Cancer Cell Uptake Efficiency

Surfactant‐free, self‐assembled iron oxide/silica core–shell (SAIO@SiO2) nanocarriers were synthesized as bifunctional magnetic vectors that can be triggered for the controlled release of therapeutic agents by an external magnetic field. In addition, drug release profiles can be well‐regulated through an ultrathin layer of silica shell. The hydrophobic drug molecules were encapsulated within the iron oxide‐PVA core and then further covered with a thin‐layer silica shell to regulate the release pattern. Remote control of drug release from the SAIO@SiO2 nanocarriers was achieved successfully using an external magnetic field where the core phase being structurally disintegrated to a certain extent while subjected to magnetic stimulus, resulting in a burst release of the encapsulated drug. However, a relatively slow and linear release restored immediately, directly after removal of the stimulus. The nanostructural evolution of the nanocarriers upon the stimulus was examined and the mechanism for controlled drug release is proposed for such a core–shell nanocarrier. Surprisingly, the surfactant‐free SAIO@SiO2 nanocarriers demonstrated a relatively high uptake efficiency from the HeLa cell line. Together with a well‐regulated controlled release design, the nanocarriers may provide great advantages as an effective cell‐based drug delivery nanosystem for biomedical applications.
Allelopathy Potential of Alpinia malaccensis (Burm. F.) Roxb. due to Seeds Germination and Growth of Merremia peltata (L.) Merril

Allelopathy is a natural strategy for the protection or inhibition toward other vegetation through the release of chemicals into the environment. Alpinia malaccensis is thought to be capable of carrying out allelopathic mechanisms, as this species is found to grow well on land invaded by Merremia peltata. Invasive type control with alleopathic mechanism is an alternative to consider as it does not leave a potential residue as a contaminant of soil as it is chemically controlled. The study attempt to investigate the content of A. malaccensis allelochemicals and analyzed the alelopathy potential of A. malaccensis on seed germination and seedling growth of M. peltata. Research method used completely randomized design with 6 replicates for seed treatment and three replicates for seedling treatment. Seeds which have relatively similar size and weight were obtained from the field. Seeds were germinated in petri dishes that have been coated by filter paper, each petri dish contained 6 seeds of M. peltata. The treatment of the seeds germination was performed by giving 3 ml of rhizomes and leaves extracts of A. malaccensis (control, 30 g/L, 60 g/L, 90 g/L, 120 g/L, and 150 g/L). The treatment of the seedlings was performed by giving 30 ml of rhizomes and leaves extracts of A. malaccensis (control, 50 g/L, 100 g/L, 150 g/L, and 200 g/L). The analysis of chemical compounds of fresh rhizomes and leaves showed that A. malaccensis contains alcohol, amide, fatty acid, phenol, ketones, and terpenoids. Rhizomes and leaves extracts 150 g/L of A. malaccensis showed the highest inhibition in germination, dry weight, plumule and radicle length of M. peltata sprout parameters. Rhizomes and leaves extract 200 g/L of A. malaccensis showed the highest inhibition in tendril length, amount of leaves, length and width of M. peltata leaves parameters. To be more efficient, application in the field should use low concentration of extracts that can inhibit the M. peltata. Results of this study are expected to provide information about alternative solutions to suppress the invasion of M. peltata to preserve ecosystems of Bukit Barisan Selatan National Park (BBSNP) in Lampung.
DIRECTIONAL COUPLER WITH GOOD RESTRAINT OUTSIDE THE PASSBAND AND ITS FREQUENCY- AGILE APPLICATION

In this paper, a directional coupler incorporating the bandpass frequency response characteristic is proposed and characterized. This structure is modifled from a conventional branch- line coupler. Two wide open-ended coupled lines are used instead of microstrip branch lines. As such, good restraint performance outside the passband can be achieved. The even-odd mode technique is employed to analyze and synthesize such a coupler. After that, frequency tuning is achieved by modifying the electrical length of the open-ended coupled lines with varactors. Measured results validate the correctness of our theory and design.
Prediction of Aero-Engine Exhaust Gas Temperature Based on Autoregressive Integrated Moving Average Model

Abstract. Forecasting the performance of aero-engine is a crucial problem that facilitates the avoiding unnecessary delays of aircraft. By applying the Autoregressive Integrated Moving Average Model to aero-engine gas path system, we find that the ARIMA method is suitable for forecast Exhaust Gas Temperature fluctuation series. Further, we find the trend of predicted values and original values are similar and the error between them is small.
Voice Flows to and around Leaders

In two studies, we develop and test theory about the relationship between speaking up, one type of organizational citizenship behavior, and unit performance by accounting for where employee voice is flowing. Results from a qualitative study of managers and professionals across a variety of industries suggest that voice to targets at different formal power levels (peers or superiors) and locations in the organization (inside or outside a focal unit) differs systematically in terms of its usefulness in generating actions to a unit’s benefit on the issues raised and in the likely information value of the ideas expressed. We then theorize how distinct voice flows should be differentially related to unit performance based on these core characteristics and test our hypotheses using time-lagged field data from 801 employees and their managers in 93 units across nine North American credit unions. Results demonstrate that voice flows are positively related to a unit’s effectiveness when they are targeted at the focal leader of that unit—who should be able to take action—whether from that leader’s own subordinates or those in other units, and negatively related to a unit’s effectiveness when they are targeted at coworkers who have little power to effect change. Together, these studies provide a structural framework for studying the nature and impact of multiple voice flows, some along formal reporting lines and others that reflect the informal communication structure within organizations. This research demonstrates that understanding the potential performance benefits and costs of voice for leaders and their units requires attention to the structure and complexity of multiple voice flows rather than to an undifferentiated amount of voice.
Behind The Eco Innovation Efforts: A Review of Dynamic Capabilities Theory

In the new millennium, scholars and business personal are actively searching a secret recipe on how to support the ability of current generations to meet their needs without compromising the ability of future generations to meet theirs. As many research discovered that eco innovation echoes to the sustainability development, research opportunity knocked the door for knowledge discovery as limited information reveals under this domain. Therefore, the purpose of this paper is to shed light on the role of eco innovation efforts towards sustainable development particularly in the automotive industries. There are five types of eco innovation that highly discussed in the literature namely eco product, process, marketing, organization and institutional. However, the technical eco innovation in forms of product and process relatively embrace by automotive industries as this industry received global forces in order to reduce pollution and waste creation. Furthermore, many scholars acknowledge that the automotive industries behave as a driver to improve sustainability performance. Secondly, this paper will discuss the secret weapons behind the eco innovation efforts underlines product and process innovation by reviewing dynamic capabilities theory. Last but not least, at the end of this paper, new paradigm for new research opportunities in automotive industries will be discussed.
New Compact Circular Ring Microstrip Patch Antennas

In this paper, three difierent compact circular-ring microstrip patch antenna structures have been proposed. These antennas have been analyzed, investigated and optimized using the CST- MW-simulator. The proposed designs are mainly based on the concept of patch shape reconflguration while its overall dimensions are kept constant. The objective is to design dual and/or triple broadband antennas resonate within the fourth generation band (4G). The presented antennas are simulated and fabricated on cheaper and lossy FR-4 substrate, and their parameters are measured and compared. The obtained results show that the proposed antenna structures resonate within the 4G frequency band. The operating bandwidths have been varied between 270.0MHz and 1000.0MHz (about 4% up to 7% of center frequency). In addition, maximum VSWR value of less than 1.5 has been achieved. The obtained results verify the validity and the beneflts of reconflguring the patch shape. Finally, good agreement has been obtained between simulated and measured parameters.
Neogaean paleomagnetism constraints on the processes at the core and surface of the Earth

General considerations According to current notions the geomagnetic eld is generated by processes in the liquid core and therefore information about its time behavior re ects the processes that occur both in the Earth s core and at its boundary with the mantle D layer On the other hand geological informa tion characterizes processes at the Earth s surface and in the lithosphere and the correlation between geo magnetic and geological phenomena re ects processes in the Earth as a coherent system including core and lithosphere A unique source of information about the time evo lution of geomagnetic eld is the paleomagnetic record imprinted in ferrimagnetic minerals which are present in the majority of rocks and preserve this information over the geological history of the Earth Available pale omagnetic data enable the analysis of geomagnetic eld behavior during long time intervals In this paper I fo cus on the Neogaea the time period covering the past Myr I have chosen this time interval because rocks older than Ma rarely compose continuous strati graphic sequences that were not subjected to signi cant transformations during their geological history and pre served the original paleomagnetic information For this reason we cannot now obtain an uninterrupted time se ries of main characteristics of the geomagnetic eld and construct the geomagnetic polarity scale for the time older than Ga
Protective effect of peroxisome proliferator-activated receptor-gamma agonists on activated renal proximal tubular epithelial cells in IgA nephropathy

Background. We have previously demonstrated a glomerulo-tubular ‘crosstalk’ operating in the pathogenesis of tubulointerstitial injury in IgA nephropathy (IgAN). The present study aims to explore any possible beneficial effect of a peroxisome proliferator-activated receptor- γ (PPAR- γ ) agonist in alleviating the tubulointerstitial inflammation in IgAN. Methods. Human tubular epithelial cells (PTEC) pre-treated with increasing concentration of a PPAR- γ agonist or troglitazone (0–5 µ M) by further incubation with the conditioned medium (IgA-HMC) collected from human Abstract Background.