Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimization of Microchannel Heat Sinks Using Entropy Generation Minimization Method

In this paper, an entropy generation minimization (EGM) procedure is employed to optimize the overall performance of microchannel heat sinks. This allows the combined effects of thermal resistance and pressure drop to be assessed simultaneously as the heat sink interacts with the surrounding flow field. New general expressions for the entropy generation rate are developed by considering an appropriate control volume and applying mass, energy, and entropy balances. The effect of channel aspect ratio, fin spacing ratio, heat sink material, Knudsen numbers, and accommodation coefficients on the entropy generation rate is investigated in the slip flow region. Analytical/empirical correlations are used for heat transfer and friction coefficients, where the characteristic length is used as the hydraulic diameter of the channel. A parametric study is also performed to show the effects of different design variables on the overall performance of microchannel heat sinks.
Herschel observations of the Sagittarius B2 cores: Hydrides, warm CO, and cold dust

Context. Sagittarius B2 is one of the most massive and luminous star-forming regions in the Galaxy and shows a very rich chemistry and physical conditions similar to those in much more distant extragalactic starbursts. Aims. We present large-scale far-infrared/submillimeter photometric images and broadband spectroscopic maps taken with the PACS and SPIRE instruments onboard Herschel. Methods. High angular resolution dust images (complemented with Spitzer MIPS 24 μm images) as well as atomic and molecular spectral maps were made and analyzed in order to constrain the dust properties, the gas physical conditions, and the chemical content of this unique region. Results. The spectra towards the Sagittarius B2 star-forming cores, B2(M) and B2(N), are characterized by strong CO line emission (from J = 4 to 16), emission lines from high-density tracers (HCN, HCO + ,a nd H 2S), [N ii] 205μm emission from ionized gas, and a large number of absorption lines from light hydride molecules (OH + ,H 2O + ,H 2O, CH + ,C H, SH + , HF, NH, NH2 ,a nd NH 3). The rotational population diagrams of CO suggest the presence of two different gas temperature components: an extended warm component with Trot ∼ 50–100 K, which is associated with the extended envelope, and a hotter component at Trot ∼ 200 K and Trot ∼ 300 K, which is only seen towards the B2(M) and B2(N) cores, respectively. As observed in other Galactic center clouds, such gas temperatures are significantly higher than the dust temperatures inferred from photometric images (Td � 20–30 K). We ,
Heterogeneity of Regional Brain Atrophy Patterns Associated with Distinct Progression Rates in Alzheimer’s Disease

We aimed to identify and characterize subtypes of Alzheimer’s disease (AD) exhibiting different patterns of regional brain atrophy on MRI using age- and gender-specific norms of regional brain volumes. AD subjects included in the Alzheimer's Disease Neuroimaging Initiative study were classified into subtypes based on standardized values (Z-scores) of hippocampal and regional cortical volumes on MRI with reference to age- and gender-specific norms obtained from 222 cognitively normal (CN) subjects. Baseline and longitudinal changes of clinical characteristics over 2 years were compared across subtypes. Whole-brain-level gray matter (GM) atrophy pattern using voxel-based morphometry (VBM) and cerebrospinal fluid (CSF) biomarkers of the subtypes were also investigated. Of 163 AD subjects, 58.9% were classified as the “both impaired” subtype with the typical hippocampal and cortical atrophy pattern, whereas 41.1% were classified as the subtypes with atypical atrophy patterns: “hippocampal atrophy only” (19.0%), “cortical atrophy only” (11.7%), and “both spared” (10.4%). Voxel-based morphometric analysis demonstrated whole-brain-level differences in overall GM atrophy across the subtypes. These subtypes showed different progression rates over 2 years; and all subtypes had significantly lower CSF amyloid-β1–42 levels compared to CN. In conclusion, we identified four AD subtypes exhibiting heterogeneous atrophy patterns on MRI with different progression rates after controlling the effects of aging and gender on atrophy with normative information. CSF biomarker analysis suggests the presence of Aβ neuropathology irrespective of subtypes. Such heterogeneity of MRI-based neuronal injury biomarker and related heterogeneous progression patterns should be considered in clinical trials and practice with AD patients.
An equivalent electric circuit for the thermal Network of the Savona Campus Smart Polygeneration Microgrid

The paper proposes a model for the thermal network of the Savona Campus Smart Polygeneration Microgrid (SPM) in terms of an equivalent electric circuit. Such model allows to represent in a simple but accurate way the behavior of the SPM thermal network in order to insert it into the Energy Management System (EMS) that is presently running in the SPM control room. The parameters of the thermal circuit are identified by means of an algorithm that minimizes the difference between the temperature profile as calculated with the circuit and the measured one.
On the extraction of the design parameters of power BJTs

In this paper, in order to decouple the design parameters of power bipolar junction transistors during their extraction, our work focuses on the study of the variation effect of the design parameters on the static and dynamic characteristics of the power BJT. Indeed, an attempt is made to assign a specific characteristic to each design parameter, which has a significant influence while taking into account the importance of each parameter variation effect on different characteristics of the transistor. This will eventually facilitate the development of an algorithm with a certain estimation order leading to an accurate estimation of the power BJTs design parameters. This algorithm will be the basis of a non-destructive estimation procedure of the design parameters of power BJTs, kept confidential by the device designers.
Motor Control of Rhythmic Dance from a Dynamical Systems Perspective a Review

While dancers and dance educators express great interest in motor control as it relates to rhythmic dance, the subject remains largely uninvestigated. In order to advance our understanding of motor control, a theoretical framework called the dynamical systems approach (DSA) has been used. The DSA was originally developed to describe mathematically the principle of synchronization patterns in nature and their change over time. In recent decades, researchers studying human motor control have attempted to describe the synchronization of rhythmic movement using a DSA. More recently, this approach has been applied specifically to rhythmic dance movements. A series of studies that used the DSA revealed that when people synchronize rhythmic movement of a body part 1. with a different body part, 2. with other people's movement, or 3. with an auditory beat with some phase differences, unintentional and autonomous entrainment to a specific synchronization pattern occurs. However, through practice dancers are able to overcome such entrainment and dance freely. These findings provide practical suggestions for effective ways of training in dance education. The DSA can potentially be an effective tool for furthering our understanding of the motor control utilized in rhythmic dance.
Simple sequence is abundant in eukaryotic proteins

All proteins of Saccharomyces cerevisiae have been compared to determine how frequently segments from one protein are present in other proteins. Proteins that are recently evolutionarily related were excluded. The most frequently present protein segments are long, tandem repetitions of a single amino acid. For some of these segments, up to 14% of all proteins in the genome were found to have similar peptides within them. These peptide segments may not be functional protein domains. Although they are the most common shared feature of yeast proteins, their ubiquity and simplicity argue that their probable function may be to simply serve as spacers between other protein motifs.
A Rigid Disc for Protection of Exposed Blood Vessels During Negative Pressure Wound Therapy

Background. There are increasing reports of serious complications and deaths associated with negative pressure wound therapy (NPWT). Bleeding may occur when NPWT is applied to a wound with exposed blood vessels. Inserting a rigid disc in the wound may protect these structures. The authors examined the effects of rigid discs on wound bed tissue pressure and blood flow through a large blood vessel in the wound bed during NPWT. Methods. Wounds were created over the femoral artery in the groin of 8 pigs. Rigid discs were inserted. Wound bed pressures and arterial blood flow were measured during NPWT. Results. Pressure transduction to the wound bed was similar for control wounds and wounds with discs. Blood flow through the femoral artery decreased in control wounds. When a disc was inserted, the blood flow was restored. Conclusions. NPWT causes hypoperfusion in the wound bed tissue, presumably as a result of mechanical deformation. The insertion of a rigid barrier alleviates this effect and restores blood flow.
Do Factors Associated with Increases in Higher Education Costs Affect Average Net Price at Four-Year Public and Private Not-for-Profit Institutions?

iv Acknowledgements.v Dedication.vi List of Tables.ix CHAPTER ONE: INTRODUCTION.11 Background of the Problem.11 Statement of the Problem.18 Research Questions.19 CHAPTER TWO: STATEMENT OF THE PROBLEM EXAMINED.2
Effects of the addition of Co on the thermoelectric properties of the AlPdMn quasicrystalline system

Partially due to their lack of periodic structure, quasicrystals have inherently low thermal conductivity, on the order of 1-3 W/mK. AlPdMn quasicrystals exhibit reasonable values of electrical conductivity (500-800 (/spl Omega//spl middot/cm/sup -1/)) and thermopower (80 /spl mu/V/K) with respect to thermoelectrics. In an effort to further increase the thermopower and hopefully decrease the thermal conductivity via phonon scattering, a fourth element was added to the nominally Al/sub 70/Pd/sub 10/Mn/sub 10/ quasicrystal. X-ray data confirms that the addition of the additional element does not alter the quasiperiodicity of the sample. Several Al/sub 70/Pd/sub 22.5/Mn/sub 7.5/ quasicrystal ingots were grown. Two subsequent batches of Al/sub 70/Pd/sub 22.5/5Mn/sub 7.5/ were grown, adding up to 2% Co. Thermopower, electrical conductivity, and thermal conductivity were measured on each sample over a broad temperature range and the results are discussed.
Lytic Promoters Express Protein during Herpes Simplex Virus Latency

Herpes simplex virus (HSV) has provided the prototype for viral latency with previously well-defined acute or lytic and latent phases. More recently, the deep quiescence of HSV latency has been questioned with evidence that lytic genes can be transcribed in this state. However, to date the only evidence that these transcripts might be translated has come from immunological studies that show activated T cells persist in the nervous system during latency. Here we use a highly sensitive Cre-marking model to show that lytic and latent phases are less clearly defined in two significant ways. First, around half of the HSV spread leading to latently infected sites occurred beyond the initial acute infection and second, we show direct evidence that lytic promoters can drive protein expression during latency.
Housing First programs in congregate-site facilities: can one size fit all?

Abstract The ‘Pathways to Housing’ Program (PHP) is an internationally recognized reference point for solutions to chronic homelessness espousing principles of ‘Housing First’. In Australian capital cities, the introduction of Housing First has mostly taken the form of congregate-site housing, unlike the scatter-site housing that has been closely associated with PHP in the United States. This has raised questions about whether the translation of the PHP model to Australia has resulted in a loss of fidelity to the ‘active ingredients’ that explain its success. Drawing on an evaluation of two congregate-site facilities in Tasmania, we show how tensions between program fidelity and local factors shaping the program assemblage, have compromised program success in relation to flexibility of service response and client agency and choice. Our findings challenge policy-makers and service providers to attend carefully to how successful overseas programs are adapted to different policy and service contexts to ensure that features critical to their success are not lost in translation.
Suppressing and enhancing band gaps with glide-symmetric surfaces

We show how ultra-large-band operation can be obtained for both wave propagating (lenses, filters) and attenuating (bandgap materials) along metasurfaces. This is achieved by realizing the metasurfaces with glide-symmetric unit cells, invariant with respect to a translation and a mirror reflection. This requires two metasurfaces made with the same periodic lattice, off-shifted of a half a period along the directions of periodicity. This symmetry condition leads to the suppression of the closed stop-band at the X point of the Brillouin diagram, while it can maximize the width of the stopband at the Γ point. On one hand, the waves propagating between the surfaces can thus see a constant equivalent refractive index over a ultra wideband, which is useful to realize planar artificial lenses. On the other hand, the wide stopband can be employed for wideband bandgap providing strong attenuation, useful to block and guide waves in integrated circuits. The geometries under analysis will be described, and simulated and measurement results will be shown to validate the study.
Support exchange patterns of the elderly in the Republic of Korea.

The authors examine support of the elderly in South Korea, with a focus on the future implications of demographic aging. "Owing to socio-economic development in the Republic of Korea and the country's success in reducing mortality and fertility, the proportion and number of elderly in the population is rapidly rising. Co-residence with adult children is the most important pattern of support for the elderly. But the elderly also contribute support in the form of financial and material assistance as well as services such as care of grandchildren. The article concludes that, because of the rapid increase in the absolute size of the elderly population, government services need to be expanded to assist in providing care for the elderly. "
P53 overexpression predicts poor chemosensitivity to high‐dose 5‐fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection

Our study aims to further clarify the prognostic significance of p53 overexpression in stage IV colorectal cancer. Between January 1994 and June 1997, we recruited 144 patients with stage IV colorectal cancers for our study, based on appropriate eligibility criteria. The patients were nonrandomly allocated to 2 treatment groups of either with or without high‐dose 5‐fluorouracil plus leucovorin chemotherapy (HDFL: 5‐Fu: 2,600 mg/m2 leucovorin 300 mg/m maximum 500 mg). Each treatment group was further divided into 2 subgroups according to the status of p53 overexpression. Therefore, 4 subgroups were allocated in our study and were designated as p53 (overexpression) HDFL (+), n = 65; p53 (normal) HDFL (+), n = 37; p53 (overexpression) HDFL (−), n = 27; and p53 (normal) HDFL (−), n = 15, respectively. All patients were prospectively followed until April 2001. There was no significant difference of the background clinicopathologic data of these 4 allocated subgroups of patients (p > 0.05). Multivariate analysis of various clinicopathologic factors of the whole group of patients indicated that age ≥60 years, poor differentiation, mucin production, CEA >100 ng/ml, p53 overexpression and without chemotherapy were the significant independent poor prognostic factors (p < 0.05). Survival analyses indicated that the patients of subgroup p53 (normal) HDFL (+) survived significantly longer than those of subgroup p53 (overexpression) HDFL (+), with mean survival time (95% confidence interval [CI]) of 20.24 (16.24–24.25) and 13.29 (10.98–15.60) months, respectively (p = 0.0043, log‐rank test). In contrast, in patients without chemotherapy, the prognosis was poor regardless of their p53 status, with mean survival time (95% CI) of 6.85 (5.47–8.23) and 5.87 (4.48–7.26) months in p53 (overexpression) HDFL (−) and p53 (normal) HDFL (−) subgroups of patients, respectively (p = 0.2820, log‐rank test). Cancers of normal p53 expression responded significantly better to HDFL (p < 0.05), with mean response rate (95% CI) being 65.57% (52.18–82.96%) in subgroup p53 (normal) HDFL (+) as compared to 35.38% (23.52–47.24%) in subgroup p53 (overexpression) HDFL (+). The toxicity to HDFL was similarly minimal between p53‐normal and p53‐overexpression patients (p > 0.05). We thus concluded that the poorer prognosis of stage IV colorectal cancers with p53 overexpression was associated with their poorer chemosensitivity rather than the more biologic aggressiveness. © 2001 Wiley‐Liss, Inc.
Differences in Rat Liver Enzyme-Altered Foci Produced By Chlorinated Aliphatics and Phenobarbital

Nine chlorinated aliphatics (CAs)—1,1-dichloroethane, 1,2-dichloro ethane, 1,1,1-trichloroethane, 1,1,2-trichloroethane, trichloro ethylene, tetrachloroethylene, 1,1,1,2-tetrachloroethane, 1,1,2,2- tetrachloroethane, and hexachloroethane—were examined in a rat liver foci assay for evidence of initiating and promoting potential. Young adult male Osborne-Mendel rats (ten/group) were given partial hepa tectomies, followed 24 hr later by a single i.p. dose of either diethyl nitrosamine (30 mg/kg body weight) or CA, 1 wk later either a diet containing 0.05% (w/w) phenobarbital or daily oral gavage (5 × /wk) of CA in corn oil for 7 weeks, and sacrificed 1 wk later. Putative preneo plastic markers monitored were foci with increased γ-glutamyltrans peptidase activity [GGT( + )]. CAs were without significant effect in the initiation protocol at the maximum tolerated dose. In the promotion protocol, 1,1-dichloroethane, 1,1,2-trichloroethane, tetrachloro ethylene, 1,1,2,2-tetrachloroethane, and hexachloroethane induced significant increases in GGT( + ) foci above control levels. Two variants of GGT( + ) foci were distinguishable, one associated predominantly with phenobarbital promotion, resembling preneoplastic foci in other models, and the other associated with CA promotion, which was less intensely stained and exhibited branching, resemblingfoci undergoing redifferentiation. The marked differences in response may relate to differences in cytotoxic potential or mechanism of action of the two types of agents.
Cigarette Smoking and Risk of Non-Hodgkin's Lymphoma—A Population-Based Case-Control Study

Background: Epidemiologic evidence of an association between tobacco smoking and non-Hodgkin's lymphoma has been conflicting. This may reflect that non-Hodgkin's lymphoma comprises several distinct disease entities with different etiologies, as some studies have indicated an association between smoking and follicular lymphoma. Objective: To investigate the association between cigarette smoking and non-Hodgkin's lymphoma risk, overall and by subtype. Methods: As part of a nationwide Danish-Swedish population-based case-control study, we interviewed 3,055 incident non-Hodgkin's lymphoma patients and 3,187 population controls. All lymphomas were uniformly classified according to the WHO classification. We used unconditional logistic regression to estimate adjusted odds ratios (OR) and 95% confidence intervals (95% CI) for the association between cigarette smoking and risk of non-Hodgkin's lymphoma. Results: Cigarette smoking was not associated with the risk of non-Hodgkin's lymphoma overall (OR, 0.97; 95% CI, 0.87-1.08) nor with the major subgroups such as diffuse large B-cell lymphoma (OR, 0.94; 95% CI, 0.79-1.10), chronic lymphocytic leukemia (OR, 0.86; 95% CI, 0.72-1.02), or follicular lymphoma (OR, 1.03; 95% CI, 0.85-1.24). Female smokers were at a marginally increased risk of follicular lymphoma (OR, 1.41; 95% CI, 1.04-1.92). Men who had ever smoked had a significantly increased risk of T-cell lymphoma (OR, 1.67; 95% CI, 1.11-2.51). No dose-response association with cigarette smoking could be established for any lymphoma subgroup. Conclusion: We found little evidence of an association between cigarette smoking and non-Hodgkin's lymphoma risk overall. Although increased risks of follicular lymphoma in female smokers and of T-cell lymphoma in male smokers were suggested, no dose-response relationship was observed, leaving limited support for causality.
French 75% tax rate: An opportunity to optimize the attractiveness of the French soccer league

This paper analyzes the impact of the French 75% income tax rate on the attractiveness of the French soccer league. The concerns are less about its financial implications for clubs than about the possible decrease in its attractiveness. A classical model of professional team sport leagues is employed to measure the Nash equilibrium competitive balance and the stock of talent to assess the effect of the new taxation. We then propose two hypotheses corresponding to specific situations in the French soccer league: “social and fiscal disparities between clubs” and “sugar daddy” behavior. The new model predicts a polarization of the league and an exodus of talent, which could be mitigated by revenue sharing.
Anti-inflammatory effects of lipoxins on lipopolysaccharide-induced uveitis in rats.

PURPOSE Lipoxins exert potent anti-inflammatory and pro-resolving actions by reducing polymorphonuclear neutrophil (PMN) infiltration. This study describes the effect of lipoxin A4 and a stable analog on the resolution of ocular inflammation induced by intravitreal injection of lipopolysaccharides (LPS) in rats. METHODS Six- to eight-week-old male Sprague Dawley (SD) rats were injected intravitreally with 2.5 microL physiologically balanced solution (LPS) containing 5 ng LPS, or 5 ng LPS + 50 ng LXA4 or 5 ng LPS + 50 ng 15-epi-LXA4 analog. Rats were anesthetized with intraperitoneal injection of a ketamine and xylazine cocktail. At 24 h, the animals were again anesthetized and the eyes examined for clinical signs of inflammation. The animals were then euthanized by CO2 inhalation and aqueous humor was collected in heparinized saline. Aqueous humor PMNs were counted using an Improved Neubauer Hemocytometer, and the protein concentration was determined by standard procedure. After enucleation, the eyes were dissected to remove the lens and the ocular tissues were frozen in liquid nitrogen and stored at -80 degrees C. Myeloperoxidase assay was done by a standard procedure. RESULTS Compared to untreated LPS-injected controls, rats treated with either LXA4 or its stable analog had lower clinical inflammation score, significantly reduced aqueous humor PMN cell counts, aqueous humor protein levels, and the MPO values. The difference between the mean values of aqueous humor protein and MPO in the LXA4 and the analog injected eyes was not statistically significant, but PMN cell counts were significantly different. CONCLUSIONS The ocular inflammatory response to intravitreally injected LPS in rats is significantly reduced by simultaneous injection of LXA4 or its analog. This finding supports an earlier independent observation of the ocular anti-inflammatory effect of LXA4. Further investigation of lipoxins in the eye might offer a novel therapeutic approach to treating ocular inflammation in man.