Miracle-dz/UniFAR-FTUs huggingface dataset:
Generation of Trispecific Cytotoxic T Cells Recognizing Cytomegalovirus, Adenovirus, and Epstein-Barr Virus: An Approach for Adoptive Immunotherapy of Multiple Pathogens

Cytomegalovirus (CMV), adenovirus (Ad), and Epstein-Barr virus (EBV) are a major cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). Adoptive immunotherapy with donor-derived cytotoxic T cells (CTLs) directed against EBV or CMV prevents the clinical manifestations of these viruses. We have designed a protocol for the simultaneous generation of polyclonal CTL specific for CMV, Ad, and EBV, which could be used to restore immunity to multiple viruses after SCT. EBV-transformed lymphoblastoid cell lines (LCLs), transduced with an adenoviral vector carrying a transgene for the immunodominant CMV antigen pp65 (Ad5f35-pp65GFP), were used to stimulate peripheral blood mononuclear cells in 6 normal donors. We detected the simultaneous presence of CD8+ CTL recognizing peptide epitopes from all 3 viruses by pentamer staining. Enzyme-linked immunospot assays demonstrated a median 29-fold (8 to 248), 47-fold (2 to 137), or 18-fold (5 to 29) increase in cells secreting interferon-γ in response to CMV, adenoviral, or EBV antigens, respectively, compared with unmanipulated peripheral blood mononuclear cell, with concomitant loss of alloreactivity. The CTL lines showed cytotoxicity against autologous LCL alone and increased cytotoxicity to autologous LCLs pulsed with CMV pp65 peptides or infected with Ad. In summary, we have developed a protocol for the generation of CTL with trivirus specificity, enabling adoptive transfer of CTL recognizing multiple viruses to restore cellular immunity after SCT.
Bénéfices de la communication inter-protocoles au niveau applicatif et des ressources pour contrôler les interférences dans les communications satellites

Cette these etudie les optimisations d’allocation de ressources dans le lien retour de systemes satellites a faisceaux multipleslimites par les interferences et pouvant etre vus comme des systemes MIMO virtuels. Cette these se focalise sur lesinterferences generees par les utilisateurs positionnes dans differents faisceaux et transmettant en meme temps et avec lameme frequence. Le nombre de frequences (couleurs) present dans le systeme satellite modifie la bande passante et de cefait la capacite du systeme. Quand ce nombre est reduit, par ex. une seule couleur, le niveau d’interferences augmente maisla bande passante dans chaque faisceau est plus grande. Il y a donc un compromis entre nombre de couleurs et niveaud’interferences. L’influence du canal satellite est tout d’abord evaluee en analysant le taux d’erreur obtenu avec diversestechniques de suppression d’interferences. La these s’oriente ensuite vers la theorie de l’information et etudie l’impact dunombre de couleurs sur les debits totaux. La detection multi-utilisateurs est prise en compte pour deriver les debitsutilisateurs et en particulier le critere max-min est applique, montrant une amelioration du niveau d’equite. Les differentsresultats sont utilises pour optimiser l’allocation des ressources mais l’ordonnancement pour des systemes MIMO a grandeechelle represente une tâche difficile, le domaine de recherche etant de taille prohibitive. De ce fait cette these etudie aussides algorithmes heuristiques a complexite reduite, bases sur la theorie des graphes, visant a trouver des ordonnancementssous-optimaux. Enfin le nombre de faisceaux et d’utilisateurs pris en compte pour l’ordonnancement sont etudies pourproposer de nouveaux algorithmes satisfaisant des contraintes de qualite de service.
Peaceful uses of atomic energy-Geneva 1955.

At the Geneva Conference on the Peaceful Uses of Atomic Energy, from August 8 to 20, 1955, some 450 papers were read and discussed, and apparently a further 600 which were not read are to be included in the Proceedings. Any report such as this can necessarily only be a record of a few personal impressions, and those requiring more detailed information should refer to the Proceedings which are about to be published by the United Nations Organisation. Five of the 16 volumes are to deal with medical applications of isotopes, biological actions of radiations, biochemical and physiological studies, safety precautions and dosimetry. In the following report the numbers of the papers referred to are given in brackets. Practically all the applications of radioactive isotopes in medicine which were discussed at the Conference have been published previously in various clinical journals. However, owing to language difficulties and the inaccessibility of the relevant publications the greater part of the work done in t.
Radiation effects on current field programmable technologies

Manufacturers of field programmable gate arrays (FPGAs) take different technological and architectural approaches that directly affect radiation performance. Similar technological and architectural features are used in related technologies such as programmable substrates and quick-turn application specific integrated circuits (ASICs). After analyzing current technologies and architectures and their radiation-effects implications, this paper includes extensive test data quantifying various devices' total dose and single event susceptibilities, including performance degradation effects and temporary or permanent re-configuration faults. Test results will concentrate on recent technologies being used in space flight electronic systems and those being developed for use in the near term. This paper will provide the first extensive study of various configuration memories used in programmable devices. Radiation performance limits and their impacts will be discussed for each design. In addition, the interplay between device scaling, process, bias voltage, design, and architecture will be explored. Lastly, areas of ongoing research will be discussed.
A Method for Content Analysis of (Pre-)Standardization Activities: The Case of Cognitive Radio

This chapter is aimed at developing a document content analysis method to be applied in studies of standardization and technology development. The proposed method integrates two theoretical frameworks: the co-evolutionary technology development framework and the “D-N-S” (design, negotiation, sense-making) framework for anticipatory standardization. At the backdrop of the complex and diversified landscape of science and R&D efforts in the technology domain, and the repeated criticism of the weak link between R&D initiatives and standardization, the authors argue that the method offered in this chapter helps better understand the internal dynamics of the technology development process at the early stage of standardization or pre-standardization, which, in turn, can help mobilize and direct the R&D initiatives. To demonstrate the practical usefulness of the proposed method, they conduct a content analysis of the research contributions presented in the COST Action IC0905 “Techno-Economic Regulatory Framework for Radio Spectrum Access for Cognitive Radio/ Software Defined Radio” (COST-TERRA).
The Influence of Market Orientation and Product Innovation on the Competitive Advantage and Its Implication toward Small and Medium Enterprises (Ukm) Performance

This study aims to: (1) determine the effect of market orientation on competitive advantage; (2) to know the effect of innovation on competitive advantage; (3) to know the influence of market orientation and product innovation together to competitive advantage; (4) the effect of market orientation on the performance of SMEs, (5) to know the effect of product innovation on the performance of SMEs, (6) to know the effect of competitive advantage on SMEs performance, and (7) to know the effect of market orientation, product innovation, and competitive advantage together SMEs. This research uses an explorative design that aims to conduct a search and reveal the factors that can be estimated as the cause of the occurrence of a condition that is not yet known the cause and the mechanism.The population in this study is the SMEs in Batam city with the type of production business with a population of 153 SMEs. The number of samples was determined using a saturated sample technique in which the entire population in the study was sampled. So the number of samples in this study was as many as 153 SMEs. From the results of the study found that market orientation has a positive and significant impact on competitive advantage. Product innovation has a positive and significant impact on competitive advantage. Market orientation and product innovation together have a positive and significant impact on competitive advantage with R2 value of 83%. The dominant variable influencing competitive advantage is product innovation with regression coefficient value 0,62. Market orientation has a positive and significant effect on SME's performance. Product innovation has a positive and significant effect on SME's performance. Competitive advantage positively and significantly influence to SMEs performance, market orientation, product innovation and competitive advantage together have positive and significant influence to SMEs performance with R2 value equal to 90%. The dominant variable affecting the performance of SMEs is the advantage of competing with the value of regression coefficient 0.47. This research offers implementation to SMEs to improve market orientation and product innovation so that it will increase competitive advantage which impact on SMEs performance.
Quinacrine Inhibits Candida albicans Growth and Filamentation at Neutral pH

ABSTRACT Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI), in part due to its strong propensity to form biofilms. Drug repurposing is an approach that might identify agents that are able to overcome antifungal drug resistance within biofilms. Quinacrine (QNC) is clinically active against the eukaryotic protozoan parasites Plasmodium and Giardia. We sought to investigate the antifungal activity of QNC against C. albicans biofilms. C. albicans biofilms were incubated with QNC at serially increasing concentrations (4 to 2,048 μg/ml) and assessed using a 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay in a static microplate model. Combinations of QNC and standard antifungals were assayed using biofilm checkerboard analyses. To define a mechanism of action, QNC was assessed for the inhibition of filamentation, effects on endocytosis, and pH-dependent activity. High-dose QNC was effective for the prevention and treatment of C. albicans biofilms in vitro. QNC with fluconazole had no interaction, while the combination of QNC and either caspofungin or amphotericin B demonstrated synergy. QNC was most active against planktonic growth at alkaline pH. QNC dramatically inhibited filamentation. QNC accumulated within vacuoles as expected and caused defects in endocytosis. A tetracycline-regulated VMA3 mutant lacking vacuolar ATPase (V-ATPase) function demonstrated increased susceptibility to QNC. These experiments indicate that QNC is active against C. albicans growth in a pH-dependent manner. Although QNC activity is not biofilm specific, QNC is effective in the prevention and treatment of biofilms. QNC antibiofilm activity likely occurs via several independent mechanisms: vacuolar alkalinization, inhibition of endocytosis, and impaired filamentation. Further investigation of QNC for the treatment and prevention of biofilm-related Candida CR-BSI is warranted.
On the Building Countermeasures of Content Bank Based on Digital Content Industry

Digital content industry is the core of emerging cultural industry. If it wants to realize the transformation from “Platform is king” to “Content is king”, it needs the external technology’s support. Content and technology restrict each other and develop jointly. Both of them promote the development of the digital content industry fundamentally. This article makes an analysis of content and technology’s present situation that base on a new point of view, and analyzes digital content industry’s developing status quo and problems from the microscopic level, then it proposes the idea of “content bank” , and shows that content bank’s operating system to promote the digital content industry to develop rapidly and healthily.
Effect of increased pressure on ventricular growth in stage 21 chick embryos.

We studied the effect of increased ventricular pressure on heart growth in the stage 21 (3.5-day) chick embryo. Ventricular pressure was increased by constricting the conotruncus with a loop of 10-0 nylon tied in an overhand knot. The embryos were reincubated, and physiology and cellular morphology were evaluated at successive stages of development, stages 21, 24, 27, and 29. Ventricular pressure was measured with a servo-null pressure system, and cardiac output was measured with a 20-MHz pulsed Doppler velocity meter. Ventricular and embryo dry weights were measured on an electronic microbalance, myocyte organelle composition was measured by a point counting technique, and cell growth response was measured by DNA and protein assay. The conotruncal loop increased ventricular pressure in experimental compared with control embryos, i.e., at stage 24, 2.88 +/- 0.13 vs. 1.96 +/- 0.05 (SE) mmHg (P less than 0.05), respectively, without affecting cardiac output. Ventricular dry weight increased in experimental vs. control embryos, i.e., at stage 24, 114 +/- 7 vs. 85 +/- 4 micrograms (P less than 0.05), respectively, whereas embryo weights were similar between the two groups. The difference in ventricular weights was due to myocyte hyperplasia, since organelle proportion of myofibrils and mitochondria, DNA-to-protein ratio, and myocyte area were similar in experimental voice control embryos. Thus the adjustment of myocardial mass to ventricular work occurs even during the earliest stages of embryonic development. Cardiac growth and morphogenesis are parallel but separable processes.
Effect of heme oxygenase-1 on renal function in rats with liver cirrhosis.

AIM To investigate the role of heme oxygenase-1 (HO-1) in pathogenesis of experimental hepatorenal syndrome (HRS). METHODS Rats were divided into liver cirrhotic group, zinc protoporphyrin IX (ZnPP) treatment group, cobalt protoporphyrin (CoPP) treatment group and sham group. Biliary cirrhosis was established by bile duct ligation in the first three groups. Rats in the ZnPP and CoPP treatment groups received intraperitoneal injection of ZnPP and CoPP, respectively, 24 h before sample collection. Expression of HO-1 mRNA in kidney was detected by reverse-transcription polymerase chain reaction, while protein expression was determined by immunohistochemical analysis. Hematoxylin and eosin staining was performed to observe liver cirrhosis and renal structure. Renal artery blood flow, mean arterial pressure and portal vein pressure, 24 h total urinary volume, serum and urine sodium concentrations, and creatinine clearance rate (Ccr) were also measured. RESULTS The HO-1 mRNA and protein expression levels in kidney, 24 h total urinary volume, renal artery blood flow, serum and urine sodium concentration and Ccr were lower in cirrhotic group than in sham group (P < 0.05). However, they were significantly lower in ZnPP treatment group than in cirrhotic group and significantly higher in CoPP treatment group than in cirrhotic group (P < 0.05). CONCLUSION Low HO-1 expression level in kidney is an important factor for experimental HRS.
Le concept gibsonien d'affordance : entre filiation , rupture et reconstruction conceptuelle #

The Gibsonian Concept of Affordance: Genealogy, Breaking off and Conceptual Reconstruction . Long before cognitive sciences rediscovered the mot or implications of perception, gibsonian ecology had a lready provided an account of it with the concept of affordance. Although Gibson's c oncept explicitly originates from Gestalt psychology, the exact nature of this relati onship has been almost systemati- cally forgotten, resulting in just the distancing f rom that tradition. This paper aims to analyze the nature and the scope of such a distanci ng. It seems necessary, then, to reconstruct the principle stages of the genesis of the concept of affordance among gestaltists and to confront the gibsonian conceptio n to these preliminary works. Gibson did not entirely succeed in providing a defi nitive definition of affordance and it is instructive to analyze the level at which som e contemporary psychologists try to improve this definition. Yet, even if these debates inside the ecological movement elucidate some problems peculiar to the concept of affordance, the aim of this paper is essentially to show that the distancing sought by G ibson has led to an important reduction of the original concept of affordance.
Awareness and knowledge of takaful in Malaysia: a survey of Malaysian consumers

Insurance, nowadays, is no longer a luxury rather a necessity. Government regulations and employment are two very important factors that contribute to the huge overall growth of the insurance industry because they force general public to buy it. The concept behind conventional insurance is contrary to the principles of Islam and socio-ethical perspective. The purpose of Shari’ah is to create and maintain a harmonious social environment by moulding our conducts in all aspects of our ritual and daily life.Takaful industry remains to be relevant even after three decades of its introduction due to the continuous demands from the multiracial and multi-ethnic participants from various backgrounds. The said industry celebrates the contributions of their stakeholders, namely the Takaful operators, Shari’ah advisors and the participants or customers. Additional credit for the progressive development of Takaful industry goes to the consistent guidelines from the regulators. However, one factor that hinders further development of Takaful industry is the lack of awareness of its presence and purpose in Malaysian market. Therefore, this paper was designed to examine the knowledge and awareness of Takaful among Malaysian consumers in Malaysia by collecting primary data through survey questionnaires. Out of the 600 questionnaires that were sent to consumers in greater Malaysia i.e. Kuala Lumpur and Selangor, we received 503 questionnaires. Random selection was used to select the sample from the known population. The findings show that out of the 503 respondents, 124 have no knowledge of Takaful and 45% are not aware that Takaful policy holders share risks mutually. Also, 33.2, %, 38.8% and 37.2% do not know that Takaful is free from gambling, uncertainty, and interest.70. 2% respondents, however, think that Takaful products comply with Shari’ah.
Seven Novel Mammalian SNARE Proteins Localize to Distinct Membrane Compartments*

SolubleN-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) proteins of the vesicle-associated membrane protein (VAMP) and syntaxin families play a central role in vesicular trafficking through the formation of complexes between proteins present on vesicle and target membranes. Formation of these complexes is proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. In order to further understand the molecular mechanisms that organize membrane compartments, we have characterized seven new mammalian proteins of the VAMP and syntaxin families. The proteins are broadly expressed; however, syntaxin 13 is enriched in brain and VAMP 8 in kidney. The seven novel SNAREs localize in distinct patterns overlapping with Golgi, endosomal, or lysosomal markers. Our studies support the hypothesis that evolutionary radiation of these two gene families gave rise to sets of proteins whose differential expression and combinatorial associations define and organize the membrane compartments of cells.
An Investigation into Job Satisfaction and Turnover Intentions amongst Engineers in Gauteng

The study of job satisfaction is central to the behaviour of employees within an organisation. The organisation under study noted an increasing record of engineers that keep coming back to request Progressive International to replace them with another organisation. The study aims to establish job satisfaction amongst engineers and its impact of turnover intention in Gauteng region. Â Findings from the primary study concluded that the variables that influence job satisfaction and ultimately turnover intentions included recognition, opportunities for career growth, pay, the size of the organisation, and demographic variables such as age, gender and educational qualifications continuously predict turnover intentions. The results also revealed that the level of job satisfaction plays a significant role in the turnover intentions of an employee. It is recommended that organisations should involve employees in key strategic decision making processes of how best to improve the job satisfaction levels of engineers who are often a scarce skill in South Africa. There is need for continuous involvement and participation of employees in decision making regarding the maintenance of job satisfaction levels
Effect of Corporate Governance on Islamic Banking: Evidence from Listed Firms of Pakistani Stock Exchange

The Purpose of this study is to analyze the influence of corporate governance on firm performance (Islamic Banks) in Pakistan. The study presents a longitudinal assessment of the compliance and implications of the revised code on firm performance. This study uses data from listed firms of Pakistan Stock Exchange (PSE) for the years 2007-2016 to investigate the effect of corporate governance, indices the performance of Islamic Banks. The study uses panel data analysis and random effect model. We used board size, CEO duality, board independence, director ownership, and frequency of meeting as corporate governance indices, ROE, and ROA as performance of Islamic banks proxies. The results have intimation for regulatory authorities, shareholders and directors to take steps to improve the board competencies for better performance.