Miracle-dz/UniFAR-FTUs huggingface dataset:
Cost and benefits of a multidisciplinary intensive diabetes education programme.

OBJECTIVES To determine the cost and benefits of an intensive diabetes education programme for patients with prolonged self-management problems and to determine the inclusion criteria for optimal outcomes. METHODS Sixty-one participants of a multidisciplinary intensive diabetes education programme (MIDEP) were measured before they started the intervention (T0), and at 1-year follow-up (T1). Data on glycaemic control (HbA1c), diabetes-related distress (PAID) and costs were obtained. Changes over time were analysed and means at T0 and T1 were compared to a reference group of 230 non-referred consecutive outpatients. The number needed to treat (NNT), that is, the number of patients to be treated to achieve one successful case, was calculated for different baseline values of HbA1c and PAID to determine optimal inclusion criteria. RESULTS Diabetes-related costs decreased significantly and participants improved significantly in HbA1c and diabetes-related distress following MIDEP. HbA1c and distress reached the levels of the reference group. The T1 costs remained higher than in the reference group, but the reduction in costs outweighed the intervention costs. Including patients with baseline HbA1c>or=8.0% and/or PAID scores>or=40 would improve the NNT to achieve clinically relevant outcomes, while 76% of the patients matched these inclusion criteria. CONCLUSIONS MIDEP is effective in improving glycaemic control and diabetes-related distress for patients with prolonged self-management difficulties. Besides the immediate reduction in costs found in the present study, improved glycaemic control may reduce future costs of diabetic complications. Stricter inclusion criteria with respect to HbA1c and PAID scores may further improve the programme's efficiency.
L'evolution des plages de l'ouest du golfe du lion au xxeme siecle. Cinematique du trait de cote, dynamique sedimentaire, analyse previsionnelle.

Sur la cote mediterraneenne francaise, l'ouest du littoral du golfe du lion est caracterise par la presence d'une serie de lagunes fermees par des cordons sableux qui ont fait l'objet d'amenagements denses au cours des dernieres decennies. Aussi, cet environnement dynamique, deja fragilise par une recrudescence des evenements tempetueux ainsi que par une diminution de la charge alluviale apporteepar les fleuves, consequence de leur equipement en barrages et de la multiplication des extractions de granulats dans leur lit, est-il aujourd'hui serieusement destabilise. L'erosion domine et des ouvrages lourds de defense ont ete mis en place pour enrayer le recul de la cote. L'objectif premier de la recherche a ete d'etudier l'evolution de la ligne de rivage au cours de ce siecle et d'essayer de prevoir ce qu'elle pourrait etre lors des prochaines decennies. Son comportement recent peut etre apprecie par l'analyse de photographies aeriennes couvrant les soixante dernieres annees ainsi que par l'etude de profils de plage leves pendant une dizaine d'annees. Des essais ont ete faits pour quantifier les transports sedimentaires le long de la cote en recourant a differentes methodes dont les resultats font l'objet de comparaisons. Des propositions pour une meilleure gestion, en particulier dans les secteurs ou l'erosion devrait se poursuivre, sont avancees.
Einfluss von Luzernebeständen auf den mikrobiellen Kohlenstoff und Stickstoff in der Ackerkrume und im Unterboden im pannonischen Klimaraum Ostösterreichs

In ostosterreichischen Ackerbaugebieten ist auch im Okologischen Landbau die viehlose Bewirtschaftungsform ublich. Der Hauptanteil des Stickstoffbedarfes wird uber den Einsatz von Futter- und Kornerleguminosen sowie Leguminosen im Zwischenfruchtanbau gedeckt. Die Nutzung von Futterleguminosen erfolgt als Grundungung, bei der der Aufwuchs am Feld verbleibt (Mulch). Die Leguminose wird als Reinkultur oder im Gemenge mit Gras angebaut. Es sollte geklart werden, ob durch die Wurzelmasse und das tiefreichende Wurzelsystem unter Futterleguminosenbestanden die mikrobielle Biomasse bereits nach einmaligem, uberjahrigen Anbau von Leguminosen, v.a. im Unterboden, gefordert wird. Weiters wurde untersucht, ob Unterschiede aufgrund der Art des Nutzungsregimes (Mulch versus Schnitt und Biomasseabfuhr) erkennbar sind.
Linking performance with payment: implementing the Physician Value-Based Payment Modifier.

PHYSICIANS ARE LEADERS OF PATIENT CARE TEAMS AND decision makers for system-based investments that facilitate quality improvement. The National Quality Strategy established 3 aims of improving health, improving health care, and reducing cost. The Centers for Medicare & Medicaid Services’ (CMS’s) value-based purchasing (VBP) programs create incentives for physicians to pursue these aims and to reward value more so than volume. Physicians’ leadership role in the health system makes incorporating physicians into the VBP portfolio critical to realizing the potential of these programs. The Physician Value-Based Payment Modifier (value modifier), part of the Affordable Care Act, links physician performance in quality and cost with Medicare Part B payments. Medicare Part B covers services such as laboratory tests, surgeries, and physician visits. CMS recently finalized a rule implementing the value modifier, including initial eligibility, measures of quality and cost, and the effect of physician performance on payment. This Viewpoint provides an overview of the program, its effect on physicians, and aims to engage physicians in a dialogue about how the value modifier should evolve over the course of implementation.
The Wisdom to Know the Difference : Strategy-Situation Fit in Emotion Regulation in Daily Life Is Associated With Well-Being

The ability to regulate emotions is central to well-being, but healthy emotion regulation may not merely be about using the “right” strategies. According to the strategy-situation-fit hypothesis, emotion-regulation strategies are conducive to well-being only when used in appropriate contexts. This study is the first to test the strategy-situation-fit hypothesis using ecological momentary assessment of cognitive reappraisal—a putatively adaptive strategy. We expected people who used reappraisal more in uncontrollable situations and less in controllable situations to have greater well-being than people with the opposite pattern of reappraisal use. Healthy participants (n = 74) completed measures of wellbeing in the lab and used a smartphone app to report their use of reappraisal and perceived controllability of their environment 10 times a day for 1 week. Results supported the strategy-situation-fit hypothesis. Participants with relatively high well-being used reappraisal more in situations they perceived as lower in controllability and less in situations they perceived as higher in controllability. In contrast, we found little evidence for an association between greater well-being and greater mean use of reappraisal across situations.
Understanding subjects contained in Dunhuang mural images for deep semantic annotation

The purpose of this paper is to understand the subjects contained in the Dunhuang mural images as well as their relation structures. ,This paper performed content analysis based on Panofsky’s theory and 237 research papers related to the Dunhuang mural images. UNICET software was also used to study the correlation structures of subject network. ,The results show that the three levels of subject have all captured the attention of Dunhuang mural researchers, the iconology occupy the critical position in the whole image study, and the correlation between iconography and iconology was strong. Further analysis reveals that cultural development, production, and power and domination have high centralities in the subject network. ,The research samples come from three major Chinese journal databases. However, there are still many authoritative monographs and foreign publications about the Dunhuang murals which are not included in this study. ,The results uncover the subject hierarchies and structures contained in the Dunhuang murals from the angle of image scholarship which express scholars’ intention and contribute to the deep semantic annotation on digital Dunhuang mural images.
Adrenal steroidogenesis in rats bred for susceptibility and resistance to the hypertensive effect of salt.

Adrenal steroidogenesis was studied in rats specifically bred for resistance (R) or susceptibility (S), respectively, to the hypertensive effects of salt. S compared to R rats showed higher 18-hydroxydeoxycorticosterone (180HDOC) levels in adrenal venous blood and peripheral plasma. S rat adrenals in vitro produced twice as much 180H-D0C as R rats. The higher 18-hydroxylase activity in S rats was exactly offset by lower llβ-hydroxylation in S rats. This gave rise to characteristic ratios of 18OH-DOC/corticosterone (B) formed in vitro by S and R rat adrenals. Salt feeding did not alter these results. in vitro data from individual rats of several strains suggest that rats fall into 2 phenotypes: those with a high 180H-D0C/B ratio of . 65–. 80 (S-type) and those with a low ratio of . 2–. 45 (R-type). Both phenotypes were seen in Sprague-Dawley rats, the strain from which S and R rats were developed. It was concluded that the clear separation of these 2 phenotypes by the selective breeding program which produced .
Correlations between indebtness grade and the value of companies in metallurgical industry of Romania

C. Oprean, Faculty of Economic Sciences, Lucian Blaga University of Sibiu, G. Dobrotă, Faculty of Economic Sciences and Business Administration, “Constantin Brâncuşi” University of Târgu-Jiu, Romania. The purpose of this paper is to identify the influence of degree of indebtedness, the level of equity capital and the net result on the value of metallurgical companies, represented by their market value. The paper presents a model developed based on data of 10 companies listed on the Bucharest Stock Exchange (BSE) in the period 2004-2013, which operates in the metallurgical industry in Romania.
Synchronous Boost Converter With High Efficiency at Light Load Using QSW-ZVS and SiC mosfets

A converter intended to be used for the interconnection of battery-based energy storage systems with the cells of a multilevel converter is addressed in this paper. High efficiency at light and medium loads is important in these applications and it can be achieved using soft switching techniques. Two control techniques with fixed and variable switching frequency are proposed and compared. The use of silicon carbide (SiC) mosfets provides a higher attainable switching frequency, which is especially interesting in variable frequency control techniques, allowing the operation at high voltages and high switching frequencies, with high efficiencies over a wide power range. A synchronous boost DC/DC converter rated for 400 to 800 V and 10 kW is designed and developed with SiC mosfets obtaining efficiencies higher than 97% from 100% to 3.5% of full load using a variable switching frequency (up to 200 kHz) control. Significant efficiency improvement is achieved at medium and light loads.
The influence of R&D partnership network on firm performance based on the perspective of social network: The case of Taiwan LED sector

Scholars have drawn on network literature to highlight the importance of external resources available to the firm through its networks. This purpose of this study is to investigate whether the position of R&D partnership network affect the firm performance. Based on this perspective, we examine the effect of the government-sponsored R&D consortia in Taiwan. This kind of policy encourages firms to take part in innovative technology fields, to develop technologies with strong potential for huge economic benefits, and to encourage academia and industry to collaborate and ultimately increase industrial competitiveness. We construct the R&D partnership network in Liquid crystal display (LED) industry by using 140 firms and test the hypothesis by using 60 listed public firms. The results show that firm joined in government-sponsored R&D consortia has better centrality and the structure hole than the others. Result also indicates a positive relationship between centrality, and patent number and structure hole and patent number but the network position of firms did not influence the firm financial performance. This study may lead to better understanding of effect from the government-sponsored R&D consortia and of the relationship between the firm network position and firm performance. The article concludes with implications for theory, research, and practice.
Triple-hop distance as a valid predictor of lower limb strength and power.

CONTEXT Hop tests are functional tests that reportedly require strength, power, and postural stability to perform. The extent to which a triple-hop distance (THD) test measures each of these characteristics is relatively unknown. OBJECTIVE To determine the extent to which the THD predicts performance on clinical measures of power, strength, and balance in athletic individuals. DESIGN Within-subjects correlational study. SETTING Station-based, preseason screening of athletes. PATIENTS OR OTHER PARTICIPANTS Forty National Collegiate Athletic Association Division I-AA men's and women's soccer student-athletes (20 women, 20 men; age = 20.0 +/- 1.4 years, height = 172.8 +/- 9.2 cm, mass = 71.9 +/- 8.9 kg). INTERVENTION(S) As part of a comprehensive preseason screening of athletes, participants completed the Balance Error Scoring System (BESS) test, 3 trials each of the THD and vertical jump, and 5 repetitions each of concentric isokinetic quadriceps and hamstrings strength testing at 60 degrees /s and 180 degrees /s. Bivariate correlations and linear regression analyses determined the extent to which THD (cm) predicted each of the strength, power, and balance measures. MAIN OUTCOME MEASURE(S) Maximal vertical jump height (cm), total BESS error scores, and quadriceps (Quad(60), Quad(180)) and hamstrings (Ham(60), Ham(180)) isokinetic maximum peak torque (Nm) at 60 degrees /s and 180 degrees /s, respectively. RESULTS Triple-hop distance was a strong predictor of vertical jump height, explaining 69.5% of the variance (P < .01). THD also predicted 56.7% of the variance in Ham(60) (P < .01), 55.5% of the variance in Ham(180) (P < .01), 49.0% of the variance in Quad(60) (P < .01), and 58.8% of the variance in Quad(180) (P < .01). No relationships between THD and BESS scores were noted. CONCLUSIONS Triple-hop distance is a useful clinical test to predict an athlete's lower extremity strength and power. Although THD was not a predictor of static balance, further research is needed to examine its relationship with more dynamic balance tests.
Detection of the myo‐inositol 4.06‐ppm resonance by selective J rewinding: Application to human prefrontal cortex in vivo

A new proton NMR single‐voxel spectral editing strategy for the rapid measurement of myo‐inositol in human brain is proposed. The spectral editing detects the 4.06‐ppm, weakly coupled resonance by means of selective J rewinding. An 84.6‐ms‐long quadruple‐resonance selective 180° radiofrequency pulse, implemented within an adiabatic‐refocused localization sequence, induces an in‐phase triplet at 4.06 ppm, while eliminating the contribution from creatine, phosphorylethanolamine, lactate, and serine in this spectral region. The myo‐inositol concentration in human prefrontal cortex is estimated to be 5.7 ± 0.9 μmol/g (mean ± SD, n = 7), with reference to NAA at 10 μmol/g. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.
Dynamics of Insulin Release and Microtubular‐Microfilamentous System

Abstract. A model is proposed to account for the phasic nature of insulin release. It is suggested that one modality of secretion results from the mobilization of secretory granules already located in the close vicinity of the microfilamentous cell web. This corresponds to a fraction of the initial secretory response to a high glucose concentration, the residual release of insulin provoked by glucose in the presence of diazoxide, and the total release of insulin evoked by sulphonylurea at a low glucose concentration. A second modality of release, which is characteristic of the late phase of glucose‐induced insulin secretion, is thought to correspond to the mobilization of secretory granules transported to the periphery of the β‐cell along oriented microtubular pathways. Whether only one or both modalities of release are initiated by a given insulinotropic stimulus may depend on the magnitude and duration of the changes induced by secretagogues in the insular handling of calcium.
Collocational Grammar as a Model for Human-Computer Interaction

C o n t r a r y t o the l o n g h e l d b e l i e f o f t r a n s f o ~ n a t i o n a l E~mmar i ans f o r communica t ion i n g e n e r a l , t he m a j o r i t y c f natural languaEe sentences which people actually use in oomm u n i c a t i n g w i t h a c o ~ p u t e r , i n an u n c o n s t r a i n e d mode, a r e no t n o v e l . As Thompson and Thompson 1981s660 obselwez "monotony o f s t r u c t u r e i s t h e r u l e r a t h e ~ than the e x c e p t i o n i n homancompute r communica t ion . " Thompson 1981"41 r e p o r t s i n h e r study of such communications that 75 percent of the queries were w h q u e s t i o n s , 1% p e r c e n t were commands, 5 p e r c e n t were s t a t e m e n t s , and 1 p e r c e n t were y e s / n o q u e s t i o n s . The r e p e t i t i v e f e a t u r e o f n a t u r a l l anguage i s not a new c o n c e p t . S i m i l a r o b s e r v a t i o n s have been made b s f o r e o Damerau 1971 used c o l l o c a t i o n o f l e x i o a l i t e m s as t he b a s i s f o r a Marker model i n an expe r imen t f o r t e x t g e n e r a t i o n . B e c k e t c l a i m s t h a t " t h e w o n d e r f u l f e a t s o f t h e homan i n t e l l e c t . , a r e based as much on m e m o r i z a t i o n as on any impromptu p rob l em-solving" (1975:62). He posits a phrasal lexicon oonslstln~ of six major categories of lexioal phrases by which we "stitch t c g e t h e r swatches o f t e x t t h a t we have hear~ b e f o r e | p r o d u c t i v e p r o c e s s e s have t h e s e c o n d a r y r o l e o f a d a p t i n g the o l d phrases to the new situations" (1975z60)o All of these approaches to natural languaEe data rely heavily on the observation that many lexlcal items tend
Oncogenes and Tumor Suppressors p 53 Activity Dominates That of p 73 upon Mdm 4 Loss in Development and Tumorigenesis

Mdm4 negatively regulates the p53 tumor suppressor. Mdm4 loss in mice leads to an embryonic lethal phenotype that is p53dependent. Biochemical studies indicate that Mdm4 also binds p73, amember of the p53 family, with higher affinity than p53. In this study, the significance of the Mdm4 and p73 interaction in vivo during embryogenesis and tumorigenesis was examined. The data revealed that p73 loss did not rescue either the early Mdm4-deficient embryonic lethality or the runted phenotype ofMdm4 p53þ/ embryos. Furthermore, studies in the developing central nervous systemwherein both genes have prominent roles indicated that loss of p73 also did not rescue theMdm4-null brain phenotype as did p53 loss. This p53 dependency occurred despite evidence for p73-specific transcriptional activity. In tumor studies, the combination of Mdm4 overexpression and p73 loss did not alter survival of mice or the tumor spectrum as compared with Mdm4 overexpression alone. In summary, these data demonstrate that the Mdm4–p73 axis cannot override the dominant role of p53 in development and tumorigenesis. Implications: Genetic characterization of the Mdm4 and p73 interaction during development and tumorigenesis suggests new insight into the role of p53 family members, whichmay influence treatment options for patients. Mol Cancer Res; 14(1); 1–10. 2015
Differentiation‐associated surface antigen variation in the ancient eukaryote Giardia lamblia

Encystation of Giardia lamblia is required for survival outside the host, whereas excystation initiates infection. The dormant cyst was considered an adaptation to external survival and passage through the stomach. However, we found previously that trophozoites which had recovered after completion of the life cycle had switched their major variant surface protein (VSP), called TSA 417, but neither the timing nor the molecular mechanism of switching had been elucidated. Here we demonstrate that TSA 417 predominates in cysts, but is downregulated during the stage of excystation that models cyst arrival in the small intestine. Transcripts of new VSPs appear late in encystation, and during and after excystation. Trophozoites appear to prepare for switching during encystation, when the major VSP on the cell surface diminishes and is internalized in lysosome‐like vacuoles. As short‐range DNA rearrangements were not detected, giardial VSP switching during differentiation appears to resemble the in situ switching of surface glycoproteins in African trypanosomes. We also report a unique extended 15 nucleotide polyadenylation signal in all VSP transcripts, but not in other known giardial genes. Antigenic variation during encystation–excystation may be a novel form of immune evasion that could help explain the common occurrence of reinfection by Giardia and other parasites with similar life cycles.
Immunologic Monitoring of Clinical Trials in Patients with Cancer: Technology Versus Common Sense

Monitoring of CTL or helper T -cell responses to tumor antigens in the course of clinical trials is an essential and necessary component of specific immunotherapy of cancer. While a variety of new immunologic or molecular technologies are now available for measuring these responses at a single-cell level, none has been standardized or validated to meet this need. The clinical investigator is thus faced with a selection of a method that is most likely to meet the desirable objective of establishing a correlation between clinical and immunologic responses to biotherapy. Selection of a relevant assay for this purpose is not a trivial task. Furthermore, few immunologic techniques can be easily adapted to reliable serial monitoring of patients on clinical protocols. , The ELISPOT assay performs well in this setting, allowing for tracking of antigen specific T cells in the peripheral blood of cancer patients who receive tumor vaccines. In our hands, this assay is sensitive, accurate and cost effective. Its reliable performance in the context of clinical vaccination trials is highly likely to provide information necessary for optimizing vaccine administration to cancer patients, including timing, route of delivery, antigen concentration and use of DC or other adjuvants.
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

JNKs are attractive targets for treatment of obesity and type-2 diabetes. A sustained increase in JNK activity was observed in dietary and genetic models of obesity in mice, whereas JNK deficiency prevented obesity-induced insulin resistance. A similar insulin-sensitizing effect was seen upon treatment of obese mice with JNK inhibitors. We now demonstrate that treatment with the saturated fatty acid palmitic acid results in sustained JNK activation and insulin resistance in primary mouse hepatocytes and pancreatic β-cells. In the latter, palmitic acid treatment inhibits glucose-induced insulin gene transcription, in part, by interfering with autocrine insulin signaling through phosphorylation of insulin-receptor substrates 1 and 2 at sites that interfere with binding to activated insulin receptors. This mechanism may account for the induction of central insulin resistance by free fatty acids.