Miracle-dz/UniFAR-FTUs huggingface dataset:
Theoretical-practical acquisition of topics relevant to patient safety: dilemmas in the training of nursesa

Objective: To investigate content associated with patient safety included in the curricula of undergraduate nursing courses of two Brazilian higher educational institutions. Method: A descriptive survey study was carried out with 119 students of nursing courses (licentiate and bachelor degree), from August to September 2016. The topics investigated were based on the WHO patient safety curriculum guide: multi-professional edition. Armed with the data, univariate and bivariate analyses were carried out. Results: Of the 46 content areas investigated in the questionnaire, two scored high in non-achievement in theoretical or practical activities, namely "the culture of blame" and "community-acquired infection. " Licentiate and bachelor degree students reported a higher acquisition in theoretical classes (p = 0.012), whereas bachelor degree students reported similar acquisition in theory and practice (p = 0.013). Conclusion: The content mostly included theoretical and practical approaches at least once throughout the course. However, when considering content associated with patient safety-related sociocultural aspects, lower scores were found.
Tansley insight Speedy stomata , photosynthesis and plant water use efficiency

Stomatal movements control CO2 uptake for photosynthesis and water loss through transpiration, and therefore play a key role in plant productivity and water use efficiency. The predicted doubling of global water usage by 2030 mean that stomatal behaviour is central to current efforts to increase photosynthesis and crop yields, particularly under conditions of reduced water availability. In the field, slow stomatal responses to dynamic environmental conditions add a temporal dimension to gaseous fluxes between the leaf and atmosphere. Here, we review recent work on the rapidity of stomatal responses and present some of the possible anatomical and biochemical mechanisms that influence the rapidity of stomatal movements.
A 97 , 052127 ( 2018 ) Joint measurement of multiple noncommuting parameters

Jiamin Li,1 Yuhong Liu,1 Liang Cui,1 Nan Huo,1 Syed M. Assad,2 Xiaoying Li,1,* and Z. Y. Ou1,3,† 1College of Precision Instrument and Opto-Electronics Engineering, Key Laboratory of Opto-Electronics Information Technology, Ministry of Education, Tianjin University, Tianjin 300072, People’s Republic of China 2Department of Quantum Science, Australian National University, Canberra ACT 0200, Australia 3Department of Physics, Indiana University–Purdue University Indianapolis, Indianapolis, Indiana 46202, USA
SCTG: Social Communications Temporal Graph – A novel approach to visualize temporal communication graphs from social data

Shubhanshu Mishra iSchool, UIUC Smishra8@illinois.edu Communication on social channels such as social media websites, email, forums, and groups; follows an inherent temporal network structure. Herein, each communication e.g. a post, occurs at a specific point in time, which can be extracted from its metadata. Furthermore, each communication is also linked to a creator e.g. a user, organization, topic, or another communication—which created the communication. Finally, the communication items can be tagged with additional numeric metadata which can be used to score some attributes about the communication e.g. number of comments, retweets, or shares. SCTG is a web based visualization which builds on the visualization principles of –overview, zoom, filter, detailson-demand, relate, history, and extracts (Shneiderman 1996). An example of our visualization applied to a course Facebook group is shown in Figure 1. The tool allows users to highlight a timeline slice, highlight communications matching a specific creator, and identify the temporal connection between each communication and its creator. The visualization tool has also been successfully applied to visualize sentiment of tweets and it’s users as part of the SAIL project (Mishra et al. 2015). The visualization tool is aimed at highlighting the temporal communication nature of social communication channels and is made available as an open source javascript API which can be used by developers and researchers alike.
What is the Risk of Having Offspring with Cleft Lip/Palate in Pre-Maternal Obese/Overweight Women When Compared to Pre-Maternal Normal Weight Women?

Objectives: The purpose of the study was to identify the risk of orofacial cleft in the offspring of women with pre-maternal obesity/overweight when compared with pre-maternal normal weight women. Material and Methods: MEDLINE and EMBASE were searched from 1980 to July 2014 for cohort, case control and cross sectional studies. BMI were categorized according to WHO recommendation: normal weight (BMI 18.5 - 24.9), overweight (BMI 25 - 29.9) and obese (BMI ≥ 30). Results: Six studies were identified; three case control studies which were used for the meta-analysis and two cross sectional studies and one cohort study. Compared with women of recommended BMI, obese women were at increased odds of pregnancy affected by CLP (OR = 1.16; 95% CI 1, 1.34) and CP (OR = 1.14; 95% CI 0.95, 1.37). Overweight women were also at increased odds of pregnancy affected by CLP (OR = 1.06; 95% CI 0.93, 1.21) but not CP (OR = 0.89; 95% CI 0.75, 1.06). The results of the risk ratios reported in the cross sectional and cohort studies were similar to the results of the meta-analysis. Conclusions: The results of this study reveal that there is an increased risk of having offspring with orofacial cleft in obese/ overweight women. The reason for this association is not known. Although, the risk is small, it is important because of the increasing incidence of obesity.
EFFECT OF GREEN TEA ( CAMELLIA SINENSIS ) ON ACTIVITY OF SUPEROXIDE DISMUTASE ( SOD ) Ma ' rifat

Background: Oxidative stress can be triggered by exposure to psychological stress. Oxidative stress can be reduced by the consumption of exogenous antioxidants, green tea is considered able to reduce oxidative stress. The purpose of this study to examine the effect of green tea steeping on superoxide dismutase (SOD) activity in male rats strain Wistar which exposed to psychological stress. Materials and Methods: This study used Randomized Post Test Only Group Design. This experimental laboratories study used 25 male Wistar Strain white rats (Rattus Norvegicus) as experimental animals and grouped into 5 groups. Normal control group (K1), stress control group (K2) and P1 treatment group for 1 hour after green tea, P2 examination 6 hours after administration of green tea and P3 examination 24 hours after administration of green tea. Previously rats given psychological stress 1 x 24 hours in the form of sleep disturbance guard pattern, so that can occur oxidative stress. Provision of steeping green tea shortly after the treatment of psychological stress with a single dose of 3 , 6 ml per rat. Statistical analysis used Multivariate Analysis of Variance (Manova) test. Result:The result of this study, based on statistical analysis showed that there were differences SOD activity increased in 1hour, to increase again in the 6 hour and maximum increasedin 24 hour after given of green tea steeping. Conclusion: A single dose of green tea steeping in animals which undergo oxidative stress has proven to neutralize oxidative stress in all 1 hour after given of green tea steeping and its antioxidant activity remains for up to 24 hour.
StarFinder: an IDL GUI-based code to analyze crowded fields with isoplanatic correcting PSF fitting

StarFinder is a new code for the deep analysis of stellar fields, designed for well-sampled images with high and low Strehl ratio. It is organized in the form of a self-contained IDL widget-based application, with a 'user-friendly' graphic interface. We give here a general description of the code along with some applications to real data with space-invariant Point Spread Function (PSF). We present also some methods to handle anisoplanatic effects in wide-field Adaptive Optics (AO) observations.
Frequência da Síndrome de Burnout em médicos residentes

Objective: To determine the frequency and factors associated with Burnout Syndrome (BS) in resident physicians in a University Hospital at the tertiary level. Methods: prospective, cross-sectional and analytical study was carried out from April to September 2016. All resident physicians in the institution were invited to participate and sociodemographic questionnaires were applied, the presence of BS by Maslach Burnout Inventory Results: Out of a total of 370 resident physicians, 117 (31.6%) participated. There was BS in 27.3% of the participants, with 67% presenting high emotional exhaustion, 47% high depersonalization and 53% low professional achievement indexes. There was a difference when compared to those without and with BS, when there were: absence of leisure activities (17.8% versus 37.5% p = 0.04), absence of religion (22.3% versus 40.6% p = 0.04) and presence of chronic disease (20.9% versus 56.2% p = 0.04). Conclusions: BS was frequent in resident physicians, with high rates in each domain of the syndrome. There was a higher frequency of BS in participants who had no leisure time, had no religious belief and had chronic disease.
Complex approach to monitoring athletes in the scope of overtraining prevention

The article introduces the issue of monitoring intensively training athletes who wish to avoid overtraining and want their training to be as effective as possible. The current definitions of overreaching and overtraining are addressed, together with the summary of causes, development and prevention of such conditions. The focus of the article is on the overview of relevant diagnostic methods including the latest non-invasive biochemical methods. The complex approach to the selection of psychological and physiological methods to establish the degree of the internal load of athletes is emphasised. A three-degree concept of athlete monitoring according to the demandingness and periodicity of diagnostic methods usage is presented.
Long-term non-invasive ventilation for stable chronic hypercapnic COPD

ABSTRACT Introduction: Long-term non-invasive ventilation (LTNIV) for the stable hypercapnic chronic obstructive pulmonary disease (COPD)-patients have been a subject of much debate in the last two decades. The aim of this study was to compile the current knowledge on LTNIV in order to evaluate the effects on mortality and hypercapnia. Methods: Literature search in Pubmed, Ovid, and Embase for RCTs in Humans from January 2000 through January 2019 in written English. Results: Six studies with a total of 861 patients were included. LTNIV in stable hypercapnic COPD patients significantly reduced PaCO2 but only one study found significant reduction in mortality. Conclusion: Our meta-analyses demonstrate that LTNIV significantly reduced PaCO2 in stable patients with chronic hypercapnic respiratory failure compared to standard care alone, and subgroup analyses on studies with a predefined plan for ventilation, showed a considerable trend towards significant reduction in mortality. The take home messages on LTNIV in stable hypercapnic COPD are: It is essential that the patients have stable chronic hypercapnia. The degree of stability can best be assessed after a minimum of 2 weeks following an acute hypercapnic respiratory failure (AHRF). It is important to ventilate the patient with the goal to reduce PaCO2 by at least 20% or below 6.5 kPa.
Effectiveness of an Intervention Regarding Weight Status of Selected New Mexico Kindergarten Children and their Parent’s Perceptions

The purpose of this study was to analyze pre-existing data of selected kindergarten children in New Mexico regarding the relationship between measured body mass index (BMI) and parents/guardians selfreported perceptions of their child’s weight status. The study is unique because it gives the opportunity to gauge the effectiveness of an intervention that is tailored to a child’s BMI. A total of six districts and 35 schools agreed to participate during this 2004-05 study. A total of 1,480 kindergarten children had their BMI measured by the school nurses. Two instruments were used to conduct the study, a bilingual preand post-intervention survey, and the CDC’s gender-specific body mass index for age percentile charts. The intervention materials included only literature for the parent/guardian to read. The largest variation in changes of perception occurred in the borderline categories of at risk of overweight and underweight. On the pre-intervention survey, 10% of the survey respondents accurately described their child as at risk of overweight and increased to 47% on the postintervention survey. A total of 11% of survey respondents accurately described their child’s weight status as underweight on the preintervention survey and this increased to 23% on the post-intervention survey. This study was a seminal attempt to obtain information regarding childhood obesity in the state of New Mexico, particularly among kindergarten children. Interventions regarding childhood obesity should be tailored to the parent/guardian as well as the child. Different interventions are needed for parents/guardians of children in the definitive categories of overweight and normal weight than for those parents/guardians of children who are at risk of overweight and underweight. © 2007 Californian Journal of Health Promotion. All rights reserved.
The X-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30→Met variant to 1.7-Å resolution

Abstract The x-ray crystal structures of normal human transthyretin (prealbumin) and the amyloidogenic Val-30-Met variant have been refined at 1.7-A resolution to R-values of 0.168 and 0.179, respectively, for 19,882 and 20,362 reflections (Fobs > 2.0 sigma). Standard deviations for stereochemical parameters are 0.018 and 0.022 A for bond distances, 0.030 and 0.038 A for angle distances, and 0.035 and 0.070 A for planar 1-4 distances. The newly refined normal structure shows improvement over the original structure of Blake and Swan (Blake, C. C. F., and Swan, I. D. A. (1971) J. Mol. Biol. 61, 217-224) in stereochemistry and in the conformation of the loop regions. Residues Arg-103, Thr-123, Asn-124, and Pro-125 have now been resolved, and residues 1-9 and 126-127 have been modeled with the aid of simulated annealing refinement. The functional form of transthyretin is a tetramer, having a cylindrical cavity which will bind thyroxine and an exterior binding site for the complex of retinol with retinol-binding protein. The monomer is a beta barrel flattened to become more like a sandwich with residue 30 in the interior. The methionyl for valyl substitution forces the beta sheets of the monomer as much as 1 A apart, resulting in a distortion of the thyroxine-binding cavity, in agreement with the independent observations that the Met-30 variant has low affinity for thyroxine.
Risk factors for delayed speech in children aged 1-2 years

Background Speech delay is one of the most common developmental delays in children. To minimize the negative outcomes of speech delay, risk factors should be explored to help in early patient diagnosis. Objectives To assess for associations between delayed speech in children aged 1 to 2 years and possible risk factors including gender, gestational age, birth weight, asphyxia during birth, head circumference, anterior fontanelle closure, gross motor development, duration of breastfeeding, caregiver identity, number of siblings, exposure to gadgets and television, and social interaction. Methods Parents of children aged 1 to 2 years who were treated at Dr. Cipto Mangunkusumo Hospital, and Klinik Anakku, Pondok Pinang in Jakarta from January 2018 to March 2018 were interviewed. Data were processed with SPSS Statistics for Mac and analyzed by Chi-square test and logistic regression method. Results Of 126 subjects, 63 children had speech delay and 63 children had normal speech development. Multivariate analysis revealed that the significant risk factors for delayed speech were delayed gross motor development (OR 9.607; 95%CI 3.403 to 27.122; P<0.001), exclusive breastfeeding for less than 6 months (OR 3.278; 95%CI 1.244 to 8.637; P=0.016), and exposure to gadgets and television for more than 2 hours daily (OR 8.286; 95%CI 2.555 to 26.871; P<0.001). Conclusion Delayed gross motor development, exclusive breastfeeding for less than 6 months, media exposure for more than 2 hours daily, and poor social interaction are risk factors for delayed speech development in children.
Optimized uptake time of 18F-THK5351 PET/CT in normal Thai brain

This study investigated 18F-THK5351 positron emission tomography-computed tomography (PET/CT) images to determine the optimized imaging time of radiopharmaceutical PET/CT in normal Thai population. Seventeen volunteers without any neurological or psychiatric illnesses, who showed no abnormalities upon neurological examination and the standardized uptake value ratio, were included. All subjects were diagnosed using 18F-THK5351 PET/CT and 3.0 Tesla magnetic resonance imaging (MRI). THK5351 PET/CT was operated on the co-registered MRI to draw a region of interest (ROI). A digital imaging and communications in a medical file were converted to a . img file. Next, the image file was rendered from discrete time to continuous time for plotting graphs. The ROI positions and rendered file were then used to plot a graph showing the relationship between the radiopharmaceutical uptake quantity and the interval time to determine the optimized uptake time of THK5351 PET/CT for the brains of normal Thai population, which was consequently 40–60 min.
Black bone disease of the foot: a case study of minocycline-induced bone pigmentation

INTRODUCTION Black bone disease was initially synonymous with alkaptonuria, a genetic disorder that causes destruction of connective tissue. The term black bone disease also has been used to describe minocycline-induced pigmentation in bone. Alkaptonuria is a monogenic disease leading to an enzyme deficiency that results in the accumulation of homogentisic acid (HGA). Minocycline is a broad spectrum, second-generation, semisynthetic tetracycline antibiotic that has been available for 5 decades with activity against gram-positive and gram-negative and some other organisms. The drug is commonly prescribed for various conditions, including acne rosacea and acne vulgaris, the most common form of inflammatory acne. Minocycline has recently been proven to provide antiinflammatory, immunomodulatory, and neuroprotective benefits. Additional research suggests minocycline’s antioxidant properties, calcium chelation, and inhibition activity of proinflammatory enzymes may make it suitable in the treatment of other diseases, such as human immunodeficiency virus (HIV), neuropathic pain, autism, and inflammatory bowel disease. A search of the scientific literature only found that nonperioral minocycline-induced bone pigmentation is relatively infrequent, with only a few cases documented that related directly to the foot. With research suggesting that the use of minocycline can be expected to continue and may likely increase, the prevalence of the effect of long-termminocycline use on bone is likely to increase. The author provides a case of a patient with a prior history of long-term minocycline use who was identified to have black bone disease of the first metatarsal during bunion correction surgery. Informed consent was obtained from the patient.
Protective Effects of Lanosterol Synthase Up-Regulation in UV-B-Induced Oxidative Stress

UV-B radiation may be an important risk factor in cataract etiology. After exposure to UV-B radiation, cells show imbalances in the repair of DNA damage, which induce changes in the levels of certain proteins, including alpha-crystallin, which is the most abundant protein in the lens and crucial for the maintenance of lens transparency. Lanosterol synthase (LSS), an essential rate-limiting enzyme in cholesterol biosynthesis, might play significant roles in oxidative stress and in the maintenance of lens transparency. However, the roles of LSS in UV-B-induced apoptosis are not well understood. Therefore, we irradiated female Sprague-Dawley rats with ultraviolet radiation to establish an animal model for exploring the variations in LSS expression during the early stages of UV-B exposure. In addition, we cultured human lens epithelial (HLE) cells that overexpress LSS and exposed them to UV-B radiation to explore the function of increased LSS expression in UV-B-induced apoptosis. The data demonstrated that UV-B exposure induced oxidative stress and apoptosis in rat lens epithelial cells and that irradiance exposure increased the level of lenticular damage. Additionally, UV-B exposure decreased the alpha-crystallin content and increased the expressions of Bax and cleaved caspase-3 compared with the control levels. After exposure to UV-B, the apoptosis-related index of HLE cells overexpressing LSS was lower than that of the control cells. Furthermore, ROS overproduction might activate the sirtuin 1 (Sirt1) pathway, which induced protein expressions of sterol regulatory element-binding transcription factor 2 (SREBF2), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), and LSS. However, the specific mechanism of the Sirt1 pathway needed to be further studied. In summary, UV-B exposure induced oxidative injury and resulted in crystallin denaturation and apoptosis in lens epithelial cells, and LSS might play a protective role during the early stages of this process and could be an important target in the cataract prevention.
Challenges in the Development of drugs for Systemic Lupus Erythematosus: A Regulatory Perspective

Systemic lupus erythematosus (SLE) is a debilitating disease that affects at least 5 million people worldwide. Currently, there are limited approved treatment options for patients with SLE, and a great need remains for therapies to achieve important treatment goals such as reductions in flares, prevention of organ damage, clinical low disease activity or remission. The purpose of this article is to review the current health authority guidance for the development of drugs to treat SLE and discuss some of the challenges in the development of drugs for SLE from a regulatory perspective. Given the substantial number of failed late-stage clinical trials in this indication despite the inclusion of large numbers of subjects, reviewing the regulatory guidance and complexities surrounding the development of drugs for the treatment of SLE is crucial to understand the complexities of the disease itself and the challenges and limitations to conducting successful trials evaluating the impact of treatment of new agents in SLE. As only one new drug (belimumab, trade name BENLYSTA®) with a novel mechanism of action has been approved over the last six decades, the prescribing information for belimumab will be reviewed in the context of the guidance.https://doi.org/10.21423/jrs-v07delvecchio