Miracle-dz/UniFAR-FTUs huggingface dataset:
POSITIVE ROLE OF PHYSICAL ACTIVITY IN PATIENTS WITH GERD

Objective: Objective of this study was to determine significance of physical activity in controlling symptoms of gastroesophageal reflux disease. Design and Setting: This is a cross sectional study. This study was conducted in DHQ Teaching Hospital Gujranwala Medical College Gujranwala, Pakistan. Duration: Study was started in January 2018 and completed in December 2018 consisted on 7 months duration. Patients and Methods: Total 600 cases were selected randomly from the attendants or relatives of patients who were living in the study hospital with their patients. A Performa was designed containing all necessary questions like age, gender, GERD symptoms, physical activity, time interval between dinner and going to bed to sleep. Ages of these patients were ranging from 20 to 75 years with mean age of 49.8 years. Mostly patients with GERD symptoms were above 45 years of age and they were not having habit of physical activity after taking meal. Cases with co-morbidities like heart, renal or liver disease and history of smoking or alcoholism or taking drug for any disease in previous six months were not included in the study. Sample size was calculated according to prevalence of disease 28%. With the help of Doctors of each ward questionnaire was translated into language of the subject and their answers were noted down. Cases were distributed into two main groups, those having GERD symptoms were kept in one group and those not having symptoms were kept in separate group. Data from both groups was obtained and calculated in the form of frequencies and percentage. Data was analyzed using Microsoft office and SPSS version 2014. Results were presented in the form of frequency tables and graphs. Results: There were 600 cases in this study. Out of them 260(43.3%) cases were having symptoms of GERD and 340(56.7%) were not having symptoms. In age group of 20-30 years 38.3% were having symptoms and 61.6% did not. Similarly between ages of 31-40 years in 43.7% cases symptoms were present and in 56.3% were absent, in age group 41-50 years 45.4% had symptoms, in cases with 51-60 years age 43.6% had symptoms, 44.2% cases in 60-70 years age group were having symptoms and in 46.9% cases above 70 years of age were suffering from symptoms of GERD. There were 51% female cases with GERD symptoms out of total 303 cases and 35.4% cases from 297 males gave history of GERD symptoms. It was seen that mostly cases with gastroesophageal disease belonged to male population. These symptoms were less in those cases that used to take physical activity after meals and go to bed 4 hours after dinner in 74.1% out of 193 cases. Most common symptom was retrosternal or epigastric pain or burning sensation in 75.4% cases out of those with GERD. Bitter or sour taste was reported in 49.6% and chronic cough due to reflux disease were found in 14.2% cases. Conclusion: Gastroesophageal disease is very common problem mostly in male population. It is most common in old age. Post meal physical activity and delay in sleep after having dinner reduces symptoms of GERD.
Outcome of pulmonary hypertension in patient on dialysis following kidney transplantation: an observational study

Background: Pulmonary hypertension (PH) is common among patients with end stage renal disease (ESRD) who are on dialysis and PH is associated with higher mortality rates among these patients. The impact of kidney transplantation on pulmonary hypertension is unknown. The purpose of this study is to evaluate the impact of successful kidney transplantation on pulmonary arterial hypertension in these patients on dialysis. Methods: The study was conducted on patients who underwent kidney transplantation in Department of Nephrology PSGIMSR. Patients with pulmonary hypertension pre transplant were taken up for the study after the application of inclusion and exclusion criteria and after obtaining consent. Demographic, clinical information and laboratory results were collected. The assessment of PH was done by Doppler echocardiography pre transplant and 3 and 6 months after transplant during follow up. Results: The prevalence of PH was 40%. The mean age of study population was 42 ± 8.7 years. The mean dialysis duration of study population was 32±8 months. 54.5% were male. 45.5% were female. Out of the 55 transplant recipients, 22 patients had elevated PASP on preoperative echocardiography examination. Compared to pretransplant values, a significant decrease was observed in mean SPAP values and the severity of pulmonary hypertension 3 and6 months postoperative follow up (p<0.003). Conclusions: The prevalence of pre-operative PH among dialysis patient was high. Kidney transplantation leads to considerable improvement in pulmonary arterial hypertension in patients on dialysis.
Emergence of Severe Malaria in Children Over5 Years in Libreville

Introduction and Background: Prevention measures against malaria in pregnancy and children under 5 years in Gabon have led to a reduction of morbidity and mortality of young children. We aimed to estimate the prevalence of severe malaria and to determine epidemiological profile of severe malaria in children in Libreville. Materials and Methods: We conducted a prospective study in pediatric wards of three public hospitals in Libreville. We included any child aged 0–15 years, hospitalized for the proven malarial episode: Thick drop smear positive and/or positive rapid diagnostic test. The severity of malarial access was asserted using the World Health Organization malaria severity criteria 2011. Results: Of the 2655 hospitalized children during this period, 596 (22.9%) were for proven malarial access, of which 206 (7.9%) had at least one severity criterion. The mean age of children with severe malaria was 56.1 ± 40.9 months; the sex ratio was 1.1. Among cases with severe malaria, those aged <60 months were 63.1% (n = 130/206), those over 60 months were 36.9% (n = 76/206). The cerebral forms were more important in the over 5 years: 55.3% odds ratio (OR) = 3, 9 (confidence interval [CI] 95% [2–8.3]). Anemic forms were most common in those younger than 5 years of age 66.9% OR = 4.13 (CI 95% [2.2–7.90]). Conclusion: Improved antimalarial protection for children under 5 years has led to an epidemiological transition, resulting in an increased prevalence of severe access among children over 5 years. It seems appropriate to explore preventive measures for this age group.
Study of quantitative bacterial cultures of non-bronchoscopic samples in ventilator associated pneumonia

Background: Diagnosis of VAP based on non bronchoscopic samples-ETA, NB-BAL culture. The aim is to study quantitative culture of the non-bronchoscopic sampling techniques such as Blind Broncho-alveolar lavage (NB-BAL) and endotracheal aspirates (ETA)in Ventilator Associated Pneumonia. It is a hospital based, observational study conducted in SPMCHI, Jaipur from September 2015 to September 2016.Methods: Seventy patients who were under mechanical ventilation for more than 48 hours and clinically suspected for VAP were included in the study and divided into early and late onset VAP. The NB-BAL and ETA were obtained from these patients and quantitative cultures were performed.Results: Out of the 70 samples analysed, 60 patients were found positive in BAL and 61 positive in ETA. The agreement between NB-BAL and ETA is 86.8%. GNBs remain the main burden of both early and late onset VAP. Most common organisms isolated were Enterobacter and Acinetobacter in early onset and Pseudomonas and Acinetobacter in late onset VAP. All the GNB isolates were sensitive to Polymyxin and Colistin and were resistant to majority of routinely used antibiotics.Conclusions: The quantitative culture of non-bronchoscopic samples is a useful alternative to bronchoscopy, in the diagnosis of VAP in resource deprived centers. MDR gram negative bacilli are the main causative agents of VAP.
The Effect of Prenatal Yoga on Mental Health In Pregnant Women: A Systematic Review

Background: Mental health has become a worldwide concern so that the promotion of mental health and prevention and treatment of mental illness are included in the Sustainable Development Goals 2030. Pregnant women often face the challenge of adapting to the physical, mental, and social changes associated with their pregnancies. Response to these changes can lead to common perinatal mental health disorders including depression, anxiety and stress. Methods: The design used is systematic review. Journal searches are performed on online databases such as Scopus, Science Direct, ProQuest, Google Scholar and Ebsco Host in 2007-2017. Search journals, articles and literature reviews using keywords of prenatal yoga, mental health, and pregnant women. Results: That there are fifteen articles selected from 17,196 articles obtained from five databases. All articles suggest that prenatal yoga practices are significant in lowering depression, anxiety, and stress levels during pregnancy. Conclusions: Based on the literature that has been reviewed, prenatal yoga has been done from many countries to overcome mental health problems (depression, anxiety, stress) in pregnant women who aim to improve the quality of life of mother and fetus. Therefore, this intervention is very useful for women in improving mental health during pregnancy
Liver failure after major hepatic resection, a persistent clinical conundrum

This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http:// creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact reprints@pulsus.com H resection remains the gold standard for the treatment of liver tumours (1). Balancing the excision of all clinically detectable disease with adequate clear margins and the necessity to retain adequate future liver remnant remains a significant challenge. In the majority of patient’s substantial resections can be safely performed however in those who require very extensive resections, or where there is impaired hepatic parenchymal function and regenerative capacity, surgery is associated with a significant morbidity and mortality.
Characterizing the Target of Acute Stroke Therapy

Background The development of effective therapies for acute ischemic stroke presumes the existence of potentially salvageable ischemic tissue when therapy is initiated because it is widely assumed that the effectiveness of most acute stroke therapies under development is related to reducing ultimate infarct size to promote functional improvement. Such salvageable ischemic tissue was previously labeled the ischemic penumbra and must be distinguished from irreversible injury. Summary of Review Pathological identification of irreversibility (infarction) appears to lag behind the actual development of this condition, and reversible injury after focal ischemia should be differentiated from infarction. Imaging and biochemical markers apparently can provide clues for distinguishing potentially salvageable from irreversibly injured ischemic tissue in experimental and clinical stroke. Recent positron emission tomography and MRI studies suggest that these clinically available imaging technologies will be useful for.
Danish version of the Patient-Rated Wrist/Hand Evaluation questionnaire: Translation, cross-cultural adaptation, test–retest reliability and construct validity

Introduction In Denmark, there is a growing need for valid, reliable and standardized patient-rated outcome measures for use in clinical practice and research. The Patient-Rated Wrist/Hand Evaluation (PRWHE) is a self-reported assessment of hand-related disorders that measures pain and functional difficulties in activities of daily living. The purpose of this study was to: (1) translate and cross-culturally adapt the PRWHE into Danish and (2) assess the reliability and construct validity of the Danish version in patients with hand-related disorders. Methods The PRWHE was translated and cross-culturally adapted into Danish using the dual-panel approach. A total of 97 patients with diverse hand-related disorders and a mean age of 52.6 years (SD 15.2) participated in the psychometric testing. They were assessed on two occasions. Test–retest reliability was assessed using the Intraclass Correlation Coefficient (ICC2.1) to assess test–retest, Cronbach’s alpha to assess internal consistency and a Bland–Altman plot to estimate measurement error. Construct validity was investigated by evaluating the relationship between the Danish PRWHE (PRWHE-DK) and the Danish validated version of the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH). Results Psychometric testing demonstrated an excellent test–retest reliability (ICC2.1 = 0.94) and internal consistency (alpha = 0.96). A systematic error of 1.5 and a measurement error of ± 16.1 were found. Furthermore, a strong correlation was found between PRWHE-DK and DASH (r = 0.71). Conclusions The PRWHE-DK is a reliable, valid instrument for patients with different kinds of hand-related disorders, and can be used in clinical practice and multi-cultural research studies to measure pain and functional disability.
Human Immunodeficiency Virus Infection, Treatments, and Therapy: Effect of the CCR5 Mutation

Since the beginning of the HIV epidemic, more than 70 million people around the world have been infected with HIV and about 50% of them have died. In 2016, globally, about 36.7 million people were living with HIV. The most common resistance to HIV infection is associated with a mutation on CCR5 co-receptors. Individuals who do not carry this natural resistance rely for survival on the antiretroviral therapy (ART) which is very costly and requires lifelong treatments. In addition to the Antiretroviral Therapy, other treatment methods are being developed. They include RNA and protein Interference methods and Hematopoietic Stem Cell Transplant methods. A common limitation of these methods is the potential health risks on patients being treated. Gene therapy would be a more efficient and sustainable approach of fighting this disease, in the absence of a cure. Currently, the most studied option involves the modification of the CCR5 gene to prevent the entry of the virus. The editing of this gene within the host’s DNA has been explored in three ways that include Zinc Review Article Hurst et al.; JAMMR, 28(1): 1-19, 2018; Article no.JAMMR. 45018 2 Finger Nucleases (ZFNs), Transcription Activator-like Effectors Nuclease (TALEN), and CRISPRCas9. This review is a critical analysis of progress made on HIV treatments and of studies pertinent to the chemokine co-receptor 5 and gene therapies.
Complications of cement percutaneous vertebroplasty

Nowadays, percutaneous vertebroplasty (PV) is widely used treatment method recommended for the patients after vertebral body fracture in the course of osteoporosis and some malignant tumors or primary neoplasms. PV is an example of small-invasive surgery procedure often giving spectacular clinical effect as early as in the first 24 hours after the surgery. However, in spite of clinical benefits, the method may also cause some serious adverse effects and complications. The most common complication is cement leakage outside augmented vertebral body. The aim of the study was to retrospectively assess vertebral fracture treatment effectiveness using PV as well as to analyze complications frequency. The study involved 190 surgical procedures (214 implantations) performed between 2003 and 2007. Observed complications were divided into the following groups: cannula introduction technique-related (bleeding, cerebrospinal fluid leakage, neurologic damages), cement implantation-related (asymptomatic and symptomatic cement leakage) and general complications (embolism, infection). The most common complication was asymptomatic cement leakage (18%). Obtained results were compared with published data. We discussed the influence of surgical technique modifications and changes in the used cements parameters on decrease of complications frequency.
For Whom the Sirens Toll: A Study on an Ethical Challenge in Prehospital Emergency Medicine

An emergency medical dispatcher (EMD) is a professional tele communicator who gathers information about medical emergencies, provides assistance through emergency medical advice and instruction, and dispatches emergency medical service (EMS) resources to the scene. Evidently, the types of tasks and resources that EMDs handle may change among countries (1). EMSs include the ambulance service as well as the fire and police department in some countries. Regardless of the type of EMS, the main role of an EMD is to determine the situation and location and to dispatch the EMS resources to the emergency. However, in some cases, there might be more than one emergency calls at one instance, and an EMD needs to prioritize the calls. An EMD is the person who must establish priorities for the allocation of limited EMS resources. During an emergency, the process of organizing the closest appropriate ambulance to the person in genuine need is crucial. It is called (tele) phone triage and it involves many technical, medical, and ethical challenges.
Breeding biology of least auklets on the Pribilof Islands

Aspects of Least Auklet (Aethia pusilla) breeding biology that pertain to the growth and development of chicks were studied on St. George Island, Bering Sea, Alaska, during the 1981 and 1982 breeding seasons. Yolk was 41% of fresh egg contents, a greater value than in the eggs of other alcid species. Adult incubation shifts averaged 24 hr, and both parents frequently spent the night together in the nest during both the incubation and chick-rearing periods. Adults brooded nestlings continuously during the day until 6 days post-hatching; diurnal brooding then declined gradually until cessation by Day 18. Chicks grew rapidly and achieved peak mass by 20 days posthatching; most fledged at masses greater than average adult body mass. Nestlings were fed an average of 5.3 meals day-'; meals averaged 5.4 g and consisted mostly of Neocalanus copepods. Estimates of breeding success (72% and 66% in 1981 and 1982, respectively) were about average for alcid species. The short nestling period of Least Auklet chicks is associated with frequent meal delivery and extended brooding made possible by the diurnal, nearshore foraging behavior of parents. Diurnal activity and nearshore foraging during the breeding season appear to be adaptations that minimize the duration of nesting and the associated risk of fox predation.
SRp20, hnRNP A1 and F regulate alternative splicing of insulin receptor via binding to the intronic regulatory elements

Insulin receptor has two splice variants which are produced due to alternative splicing of 36 base pair long exon 11. Inclusion and exclusion of this exon in the matured RNA produces two isoforms, B and A respectively. Previously our lab has generated a minigene construct containing exon 10–12 and the surrounding introns of human IR. Deletion mutation of this construct identified a purine rich ISE near the 5′ and an ISS near the 3′ end of intron 10. For accurate identification of these elements linker scanning mutants were created throughout the ISE and ISS. These constructs were transfected into HepG2 cell lines. The ISE mutants suggest the presence of multiple element binding sites in this region. From ISS mutants, a 12 nt long silencer sequence has been identified, deletion or mutation of which caused a constitutive incorporation of exon 11. Sequence analysis of ISE revealed that it contains potential binding sites for hnRNP A1, F and H proteins. An in vitro RNA pull down assay taking portions of the ISE sequence followed by western blot analysis confirms the binding of these proteins to this region. Co transfection of the minigene with hnRNP A1 inhibits and hnRNP F activates the inclusion of exon 11 in HepG2 cells. Co transfection of the minigene with siRNA against hnRNPA1 and F increases and decreases the inclusion of exon 11 respectively. RNA pull down assay with the ISS revealed the binding of CUG‐binding protein 1 (CUGBP‐1) and SRp20. Co transfection of wild type minigene with CUGBP‐1 inhibits the inclusion of exon 11, whereas, mutation of the 12‐nt region of the minigene abolishes the effect of CUGBP‐1. Surprisingly, co‐transfection of the minigene with SRp20 increased the inclusion of exon 11, suggesting that SRp20 might bind to an enhancer element as well. This study identifies novel intronic regulatory elements and reveals the role of hnRNP A1, F and SRp20 as regulatory proteins for IR splicing.
Perfil epidemiológico da dengue no Brasil: revisão integrativa

To describe the epidemiological profile of dengue in Brazil and is to help understand how the disease is transmitted and how is their evolution. It is relevant to the practice of nursing a deep reflection theme to analyze how the transmission of dengue is and how its process has influenced public health, and collaborates in studies of Brazilian nursing in the care and prevention of disease. It is an integrative review of the literature in databases LILACS, MEDLINE, BDENF, INTEGRALIDADE, CIDSAÚDE, ENSP, CONVISA-PROD, SESSP-CTDPROD and COLLECTS SUS, MS totaling 24 publications categorized in: epidemiological profile of dengue in Brazil, diagnosis, prevention, treatment and associated factors. We conclude that the epidemiological profile of dengue in Brazil is determined by several factors that act directly on the disease and may vary according to the group, the community, the site studied. Additional research specifically with levels of evidence IV e V, in different fields of activity of Nursing, Medicine, Dentistry, Veterinary Medicine, Psychology, Nutrition, Mathematics, Statistics, Economics, Geography, Life Sciences and Administration, covering all Brazil are requires to assist the implementation of occupational improvements. Descriptors: epidemiology, dengue, diagnosis, Brazil. 1 Estudante de enfermagem do 10operíodo da FACIPE. 2 Enfermeira. Doutoranda em Enfermagem em Educação em Saúde pela UFPE. Docente do Curso de Enfermagem da FACIPE.