Miracle-dz/UniFAR-FTUs huggingface dataset:
Topical application of growth factors after carbon dioxide fractional laser therapy: A randomized controlled split-face study

The carbon dioxide (CO 2 ) fractional laser is a widely used device for the treatment of fi ne wrinkles, acne scars and pigmentation. The mechanisms of action of CO 2 laser resurfacing include tissue ablation, immediate collagen shrinkage and dermal collagen remodelling (1). Down time with the CO 2 laser typically lasts a week or more. The growing demand for minimizing down time for patients has resulted in the development of nonablative lasers for photorejuvenation treatment. Nonablative lasers include near-infrared lasers and intense pulsed light devices. However, non-ablative lasers have only minimal effects on neocollagenesis, thereby not providing the same results as ablative laser resurfacing for the treatment of wrinkles and scars (2). Recently, fractional photothermolysis has been widely used for photorejuvenation treatment. Fractional photothermolysis is achieved by applying an array of microscopic treatment zones of thermal injury to the skin (3). Microscopic epidermal necrotic debris is formed just below an intact stratum corneum overlying each dermal wound. Although fractional thermolysis has shown acceptable clinical outcomes with less down time for patients and fewer overall adverse effects, the down time associated with ablative fractional laser treatment still remains a problem. There has been no objective method reported that can be universally used to assess down time. With the CO 2 fractional laser, the most signifi cant problem with the long down time is that microcrusts remain on patients ’ faces – the micronecrotic debris is observed in areas where the laser beam has penetrated. The down time might be accurately assessed
Persistence and characterization of idiotypes in pedigreed rabbits producing antibodies of restricted heterogeneity to pneumococcal polysaccharides.

Anti-idiotype antisera were prepared which reacted with anti-SVIII antibodies of restricted heterogeneity in the sera of two rabbits, each from a different pedigree. No sharing of the idiotypes was detectable in antisera from close relatives of each donor. We looked for shared idiotypic determinants by precipitation tests and by an inhibition of binding assay which we estimate could have detected 1% of antibody with the same idiotype. Antibody to SVIII with idiotypic determinants present during the first course of immunization of an individual rabbit reappeared during the second immunization series 12 months later. During the course of restimulation, the antiserum exhibited increased complexity. By the 4th week, antibody with the original idiotype had decreased in concentration while the total anti-SVIII reached maximum concentration.
Cosine similarity-based PageRank calculation

This paper introduces a new method for calculating the rank of a web page based on the content similarity and the link structure. There are different ranking algorithms available in the literature to calculate the importance score of web pages. The basis of all ranking algorithms is the link structure of the web. Since links from similar documents are more important than the links from other dissimilar documents, combining content similarity with link structure assigns higher ranks to more relevant documents. Cosine similarity measure is used in this paper for calculating similarity among the documents. The proposed technique is compared with existing ranking algorithms using precision, recall and F-measure.
Serum inhibins, estradiol, progesterone and FSH in surgical menopause: a demonstration of ovarian pituitary feedback loop in women.

BACKGROUND The objective of this study was to confirm the source and study the acute changes and relationship between inhibins and FSH at surgical menopause. METHODS Regularly cycling women (42-47 years; n = 10) undergoing bilateral oophorectomy for non-ovarian pathology were recruited for this study. One blood sample was taken before surgery and after removal of the ovaries, samples were taken every 15 min up to 1 h, hourly up to 6 h, after 12 h and daily during the hospital admission (3 days). RESULTS There were five women in the follicular phase and five women in the luteal phase of the cycle. For women in both phases, levels of inhibin A, inhibin B, estradiol (E(2)) and progesterone decreased after the removal of the ovaries. Serum FSH levels started to rise after 12 h in both follicular and luteal phase women after the surgical menopause. Correlation analysis showed that inhibin A and E(2) were significantly negatively correlated in both phases with FSH concentration. Inhibin B had a negative correlation in the follicular phase and progesterone had a negative correlation in the luteal phase. CONCLUSIONS This study showed that ovarian inhibin A and B were cleared from the circulation within 12 h of oophorectomy, whereas E(2) and progesterone remain in the circulation for longer. Negative correlation between FSH, inhibin A and inhibin B suggests that inhibins may contribute to the observed early rise in FSH after the surgical menopause.
shrinkage isoform 5 by protein kinases A and C and cell Acute inhibition of brain-specific Na + / H + exchanger

[PDF] [Full Text] [Abstract] , August 1, 2002; 13 (8): 2171-2177. J. Am. Soc. Nephrol. T. Igarashi, T. Sekine, J. Inatomi and G. Seki Unraveling the Molecular Pathogenesis of Isolated Proximal Renal Tubular Acidosis [PDF] [Full Text] [Abstract] , November 1, 2002; 67 (5): 1419-1429. Biol Reprod E.A. Harding, C.A. Gibb, M.H. Johnson, D.I. Cook and M.L. Day Development Developmental Changes in the Management of Acid Loads During Preimplantation Mouse [PDF] [Full Text] [Abstract] , October 1, 2006; 291 (4): R1145-R1156. Am J Physiol Regulatory Integrative Comp Physiol M. Grosell and J. Genz intestine play a role in osmoregulation Ouabain-sensitive bicarbonate secretion and acid absorption by the marine teleost fish [PDF] [Full Text] [Abstract] , January 1, 2009; 89 (1): 193-277. Physiol Rev E. K. Hoffmann, I. H. Lambert and S. F. Pedersen Physiology of Cell Volume Regulation in Vertebrates
Information Technology for Clinical, Translational and Comparative Effectiveness Research

Summary Objective: To select and summarize key contributions to current research in the field of Clinical Research Informatics (CRI). Method: A bibliographic search using a combination of MeSH and free terms search over PubMed was performed followed by a blinded review. Results: The review process resulted in the selection of four papers illustrating various aspects of current research efforts in the area of CRI. The first paper tackles the challenge of extracting accurate phenotypes from Electronic Healthcare Records (EHRs). Privacy protection within shared de-identified, patient-level research databases is the focus of the second selected paper. Two other papers exemplify the growing role of formal representation of clinical data - in metadata repositories - and knowledge – in ontologies - for supporting the process of reusing data for clinical research. Conclusions: The selected articles demonstrate how concrete platforms are currently achieving interoperability across clinical research and care domains and have reached the evaluation phase. When EHRs linked to genetic data have the potential to shift the research focus from research driven patient recruitment to phenotyping in large population, a key issue is to lower patient re-identification risks for biomedical research databases. Current research illustrates the potential of knowledge engineering to support, in the coming years, the scientific lifecycle of clinical research.
Can readmission rates be used as an outcome indicator?

There has been interest in the use of readmission rates as an outcome indicator in hospitals since at least 1965, when in their pioneering study Acheson and Barr suggested that the readmission rate might serve "as an index of the quality of medical care. "' This idea has lately regained ground,2 and readmission rates have been described as "one of the few potential measures available from routine statistics for assessing outcome. "3 This paper attempts to clarify how far readmission rates can be useful as an indicator of outcome.
Variants on 8 q 24 and prostate cancer risk in Chinese population : a meta-analysis

Previous studies have identified 8q24 as an important region to prostate cancer (PCa) susceptibility. The aim of this study was to investigate the role of six genetic variants on 8q24 (rs1447295, A; rs6983267, G; rs6983561, C; rs7837688, T; rs10090154, T and rs16901979, A) on PCa risk in Chinese population. Online electronic databases were searched to retrieve related articles concerning the association between 8q24 variants and PCa risk in men of Chinese population published between 2000 and 2014. Odds ratio (ORs) with its 95% correspondence interval (CI) were employed to assess the strength of association. Total eleven case-control studies were screened out, including 2624 PCa patients and 2438 healthy controls. Our results showed that three risk alleles of rs1447295 A (OR=1.35, 95% CI=1.19-1.53, P<0.00001), rs6983561 C (C vs. A: OR=1.41, 95% CI=1.21-1.63, P<0.00001) and rs10090154 T (T vs. C: OR=1.48, 95% CI=1.22-1.80, P<0.00001) on8q24 were significantly associated with PCa risk in Chinese population. Furthermore, genotypes of rs1447295, AA+AC; rs6983561, CC+AC and CC; rs10090154, TT+TC; and rs16901979, AA were associated with PCa as well (P<0.01). No association was found between rs6983267, rs7837688 and PCa risk. In conclusions, variants including rs1447295, rs6983561, rs10090154 and rs16901979 on 8q24 might be associated with PCa risk in Chinese population, indicating these four variations may contribute risk to this disease. This meta-analysis was the first study to assess the role of 8q24 variants on PCa risk in Chinese population.
Intrinsic platelet reactivity before start with clopidogrel as predictor for on-clopidogrel platelet function and long-term clinical outcome

Summary High on-clopidogrel platelet reactivity is associated with worse clinical outcome. Previous data suggest that intrinsic platelet reactivity before initiation of clopidogrel contributes significantly to on-clopidogrel platelet reactivity. It is unknown whether intrinsic reactivity can sufficiently predict on-clopidogrel reactivity and therefore identify patients with insufficient response to clopidogrel before initiation of treatment and at risk for worse clinical outcome. This analysis included 765 consecutive patients undergoing elective coronary stent implantation. Platelet reactivity was assessed by light transmission aggregometry (5 µM ADP) before administration of clopidogrel 600mg and after intake of first maintenance dose of clopidogrel on day 1 following coronary stenting. Patients were followed for up to seven years. The combined primary endpoint was death of any cause or non-fatal myocardial infarction. Intrinsic and on-clopidogrel platelet reactivity were significant correlated (r=0.31; p < 0.001). Among all tested clinical and genetic factors including the cytochrome P450 2C19*2 polymorphism, intrinsic platelet reactivity was the strongest predictor for on-clopidogrel platelet reactivity. However, intrinsic platelet reactivity could only explain 8 % of variability of on-clopidogrel platelet function. Only on-treatment platelet reactivity was predictive for long-term clinical outcome (HR 1.47, 95 % CI 1.05–2.05; p = 0.02) whereas intrinsic platelet reactivity was not (HR 1.03, 95 % CI 0.74–1.43; p = 0.86). In conclusion, intrinsic platelet reactivity before initiation of clopidogrel is the strongest predictor of early on-clopidogrel platelet reactivity but can only explain a minor proportion of its variability and is not significantly associated with clinical outcome. Thus, baseline testing cannot substitute on-clopidogrel platelet function testing. Clinical Trial Registration: ClinicalTrials.gov (Identifier: NCT00457236).
The effect of delayed weaning on the development of oral tolerance to soya-bean protein in pigs

The antibody response to a dietary antigen (soya-bean protein) and the development of oral tolerance was studied in pigs in a family pen system where the piglets are left with their mothers and gradually wean themselves onto a soya-bean-based diet over a 12 week period. In the first experiment three groups of pigs (eight pigs/group) aged either 2, 8 or 13 weeks were immunized with soya-bean protein or ovalbumin (OvA; controls) intra-peritoneally (i.p.) in Quill A adjuvant and subsequently boosted 2 weeks later. All groups showed an IgG response to the injected antigens indicating lack of tolerance induction to the dietary antigen. Interestingly the groups injected with OvA showed an almost identical response to soya- bean protein as the groups injected with soya-bean protein. In a second experiment with a similar protocol, soya bean was withdrawn from the feed before immunization which resulted in lack of response to soya-bean protein in the groups injected with OvA and a lack of response to injected soya-bean protein in the 14-week-old group, indicating that systemic tolerance was established by 12 weeks of age. The results from the two experiments suggest a compartmentalized response to soya-bean protein i.e. local antibody production to dietary soya bean along with systemic tolerance to injected soya-bean protein. The work also suggests that delayed‘natural’weaning may avoid damaging hypersensitivity reactions associated with early weaning.
Movement of C-Labeled Assimilates into Kernels of Zea mays L: I. Pattern and Rate of Sugar Movement.

Carbon-14, photosynthetically fixed in leaves of Zea mays L. and translocated to developing kernels, passed through specialized basal endosperm cells prior to movement into the starchy endosperm and embryo. Radioactivity migrated in the endosperm at a maximum rate of 2.7 millimeters per hour, and there was no difference in the rate of movement in kernels treated 14 to 30 days after pollination.Sucrose contained over three-fourths of the radioactivity in the kernal base (fruit stalk) 1 to 6 hours after (14)CO(2) treatment of the plant. Conversely, in the basal endosperm three-fourths of the radioactivity was in glucose and fructose. A high proportion of the radioactivity was retained in the monosaccharides of the starchy endosperm the first 3 hours after the (14)CO(2) treatment. With additional time after treatment there was a decline in the percentage of radioactivity in the monosaccharides and an increase in sucrose-(14)C. From these data we suggest that translocated sucrose is cleaved to glucose and fructose during entry into the endosperm and that the monosaccharides diffuse throughout the endosperm. Once the sugars arrive in the cells active in starch synthesis, they are rapidly converted to sucrose which in turn is utilized in the synthesis of starch.
Correlations between digital planimetry and optical coherence tomography, confocal scanning laser ophthalmoscopy in assessment of optic disc parameters.

OBJECTIVE AND AIM In routine clinical practice, laser methods for the evaluation of optic disc parameters are expensive and not accessible for all ophthalmologists; therefore, there is a need for less expensive technique. The aim of this study was to assess correlations between the parameters of the optic disc measured by digital planimetry (DP), optical coherence tomography (OCT), and confocal scanning laser ophthalmoscopy (CSLO) in healthy and glaucoma patients with the normal biometric parameters of the eye. MATERIAL AND METHODS This case-control study enrolled 40 patients with glaucoma and 32 healthy patients with the normal biometric parameters of the eye. All subjects underwent full ophthalmologic examination, digital color optic disc photography, OCT, and CSLO at the same visit. The optic disc was morphometrically analyzed by DP, OCT, and CSLO. Seven optic disc parameters were evaluated. RESULTS In the glaucoma group, the optic disc and cup areas (r=0.7-0.8, P<0.001) and cup-to-optic disc and rim-to-optic disc area ratios (r=0.7, P<0.001) measured by DP were strongly correlated with those measured by OCT and CSLO, while the horizontal and vertical cup-to-optic disc diameter ratios were found to be moderately correlated (r=0.6-0.7, P<0.001). In healthy patients, the optic disc and cup areas were strongly correlated (r=0.7-8.0, P<0.001). Significant differences in all optic disc parameters, except for the optic disc area, measured by DP, OCT, and CSLO were found between glaucoma and healthy patients. CONCLUSIONS Strong correlations between the parameters of the optic disc measured by DP, OCT, and CSLO were found. There were significant differences in the parameters between healthy and glaucoma eyes measured using DP; therefore, this technique may be used for diagnosis, management, and screening of glaucoma.
Drug‐induced reinstatement of heroin‐ and cocaine‐seeking behaviour following long‐term extinction is associated with expression of behavioural sensitization

The present study was designed to evaluate the relationship between reinstatement of drug‐seeking behaviour following long‐term extinction of intravenous (i.v.) drug self‐administration (an animal model for craving) and long‐term behavioural sensitization. Rats were allowed to self‐administer heroin (50 μg/kg per inj., 14 daily sessions), cocaine (500 μg/kg per inj., 10 daily sessions) or saline. Following a 3‐week extinction period, reinstatement tests were performed to evaluate priming effects of amphetamine, cocaine and heroin on non‐reinforced drug‐seeking behaviour. In addition, the occurrence of long‐term behavioural sensitization in rats with a history of heroin or cocaine self‐administration was determined. Heroin‐seeking behaviour was reinstated by heroin (0.25 mg/kg), amphetamine (1.0 mg/kg) and cocaine (10 mg/kg). In addition, animals with a history of heroin self‐administration displayed locomotor sensitization to both heroin and amphetamine. Cocaine‐seeking behaviour was reinstated by cocaine and amphetamine, but not by heroin. Interestingly, locomotor sensitization to amphetamine, but not heroin, was observed in animals with a history of cocaine self‐administration. In other words, the induction of drug‐seeking behaviour following a prolonged drug‐free period was found to be associated with the expression of long‐term behavioural sensitization. These data provide experimental evidence for a role of behavioural sensitization in the incentive motivation underlying drug‐seeking behaviour. If drug hyperresponsiveness would indeed be a crucial factor in drug‐induced craving in human addicts, pharmacological readjustment of the neuroadaptations underlying drug sensitization may prevent relapse to drug use long after detoxification.
Learning management systems: technology to measure the medical knowledge competency of the ACGME

Aims We report how the learning management system (LMS) Web Course Tools (WebCT) was used to design, implement and evaluate the web‐based course ‘Principles of Ambulatory Paediatrics’, taken by paediatric residents during an ambulatory block rotation. This report also illustrates how WebCT can be used to measure the medical knowledge competency required by the Accreditation Council for Graduate Medical Education (ACGME).
Type D personality, cardiac events, and impaired quality of life: a review

Background Psychological distress has been associated with the pathogenesis and progression of coronary heart disease (CHD) but little is known about the determinants of distress as a coronary risk factor. Although it has become unfashionable to focus on personality factors since research on Type A behaviour yielded inconsistent findings, personality may comprise a major explanatory factor of individual differences in stress-related CHD. This article focuses on Type D - the distressed - personality, which describes patients who experience increased negative emotions and tend to inhibit the expression of these emotions in social interactions. Methods The article reviews research on Type D personality in the context of CHD. Results Accumulating evidence indicates that cardiac patients with the Type D personality are at increased risk for cardiovascular morbidity and mortality (odds ratios ranging from 4.1–8.9, P < 0.0001) independent of standard cardiac risk factors. Type D patients are also at increased risk for psychological distress, clustering of psychosocial risk factors, impaired quality of life, and seem to benefit less from medical and invasive treatment. Preliminary evidence suggests that physiological hyper-reactivity and activation of pro-inflammatory cytokines may be responsible for the detrimental effect of Type D personality on cardiac prognosis. Conclusions There is an urgent need to adopt a personality approach in the identification of patients at risk for stress-related cardiac events. Type D is a stable personality construct that may be of special interest not only in CHD, but in other chronic cardiac conditions as well. Eur J Cardiovasc Prevention Rehab 10:241–248 © 2003 Lippincott Williams & Wilkins.
Complete nucleotide sequence of the human creatine kinase B gene.

We report on the completion of the nucleotide sequence of the gene encoding the B subunit of the Creatine Kinase (CK; EC 2.7.3.2) isozymes BB and MB (1). If compared to the partial CK-B sequence published by Daouk et al. (2) four nt. positions are at variance. Characteristic features of the CK-B gene area are highlighted in Figure 1. A double-peaked CpG-rich island overlaps the promoter region and the 5' half of the gene and coincides with two clusters of Spl-binding sites. Strikingly, the Spl-cluster around the fourth exon precedes a long open reading frame encoding a putative polypeptide of 381 amino acid residues, which runs in the opposite direction (3' to 5' strand not shown) and ends near one of the polyadenylation sites (nt. 38). The biological significance of this observation is not yet known.
Differential proteomic analysis in human cells subjected to ribosomal stress

The biochemical phenotype of cells affected by ribosomal stress has not yet been studied in detail. Here we report a comparative proteomic analysis of cell lines silenced for the RPS19 gene versus cell lines transfected with scramble shRNA cells performed using the DIGE technology integrated to bioinformatics tools. Importantly, to achieve the broadest possible understanding of the outcome, we carried out two independent DIGE experiments using two different pH ranges, thus, allowing the identification of 106 proteins. Our data revealed the deregulation of proteins involved in cytoskeleton reorganization, PTMs, and translation process. A subset (26.9%) of these proteins is translated from transcripts that include internal ribosome entry site motifs. This supports the hypothesis that during ribosomal stress translation of specific messenger RNAs is altered.
Reinstation of Signal to Be Measured in Parallel A/D Sampling System Mass

The multi-chip A/D parallel time-interleaved sampling is an effective method to improve sample-rate. However, the mismatch between the parallel channels will lead to nonuniform sampling and seriously degrade the performance of the whole sampling system. By data processing, this paper proposed a method to measure the channel mismatch errors, it is the compution of delay time by the aid of a reference sinusoidal signal, and correcte the frequency spectrum and reinstate of signal to be measured by DFT. In the MATLAB environment, simulation experiment results show that the proposed method is feasibility and reliability.