Miracle-dz/UniFAR-FTUs huggingface dataset:
Strategies for Improving Teaching and Instruction in Inclusive Education Secondary Schools in Nigeria

This paper discussed the ways through which teachers can improve teaching and instruction in inclusive education secondary schools. Also, the roles of the school principals in seeing to the effectiveness of teaching and instruction were also discussed. Teaching like every other science has a systematic way of planning teaching activities and implementing same within a specified time period. The non-adherence to these laid down rules has resulted in a lot of lapses which has resulted to the poor performance of our students in national examination. For learning to be successful, the teacher must plan, implement, and evaluate the lesson so as to ascertain the level of comprehension of the lesson by the students and also to know if the desired (stated) objectives were achieved. Introduction The poor performance of students in national examinations is becoming highly worrisome. All the various stakeholders in education are not only short of words but also seem short of ideas on how to tackle this problem which has become a yearly occurrence despite the gradual increase in students‘ performance since after 2009. But, over the years, instead of charting a common course on how to tackle this problem, the parents/guardians and the teachers have often blamed the government and the government in return are blaming the teachers for their lack of commitment to their job as one of the causes of the problem. At its meeting in November, 2009 in Ibadan, WAEC‘s National Examination Committee (NEC), agreed with the conclusion of the chief examiner‘s report that many candidates failed because ̳they could not express themselves in written English, could not interpret questions, were poorly prepared, did not write clearly, and were technically incompetent‘. They endorsed the recommendations that teachers should teach well and cover the syllabus, science laboratories should be well equipped, and candidates should be well prepared for examination and taught how to answer questions (Belo-Osagie, 2009). A critical analysis of the chief examiner‘s report will show that much of the questions lie on the teachers. For instance, how did a candidate who could not express himself/herself in written English got to that level? How has he/she being passing previous promotional examinations? These are some of the questions that must be answered if we are serious about finding lasting solutions to the problem. The teachers as
Dangers of synthetic cannabinoids (bonzai): A case report

Cannabis has become the most widely consumed illicit substance worldwide. Synthetic cannabinoids (SCs), known mostly as JWH agents, were found to have 2-100 times more potent than THC. These are obtained with very minor modifications on the original cannabinoid compound with varying chances to be detected in routine toxicological screens. Recently the use of SCs known as Bonzai has increased considerably and SC-related deaths have increased a lot. We present a male patient who was hospitalized with the history of SC (bonzai) abuse for 3 months and started to have convulsions after using SC and brought to emergency department with chest pain and loosing consciousness immediately after using SC 1 month ago. His toxicological analysis revealed no sign of illicit drugs. EEG showed paroxysmal slow waves with sharp characteristics in both hemispheres. Mortality due to SCs may be related to sudden cardiac death in the acute phase which may result from the stimulation of sympathetic nervous system and epileptic abnormalities may be due to inhibition of γ-aminobutyric acid (GABA) neurotransmission. Novel generalized seizures and chest pain especially in young people should be warning for neurologists and cardiologists in terms of potential SC abuse.
Transcriptional profiling of potato (Solanum tuberosum L.) during a compatible interaction with the root-knot nematode, Meloidogyne javanica

Root-knot nematode (RKN, Meloidogyne javanica) presents a great challenge to Solanaceae crops, including the potato. In this report, we conducted an investigation to understand the transcriptional regulation of molecular responses in potato roots during a compatible interaction following RKN infection. In this study, analysis of gene expression profiles using RNA-seq of Solanum tuberosum cv Mondial with RKN interaction at 0, 3- and 7-days post-inoculation (dpi). In total, 4,948 and 4,484 genes were respectively detected as differentially expressed genes (DEGs) at 3 and 7 dpi. Functional annotation revealed that genes associated with metabolic process were enriched at the transcriptional level suggesting they have an important role in RKN disease development. Nematode infection caused down-regulation of 282 genes associated with pathogen perception hence interfering with activation plant immune system. Further, late activation of pathogenesis-related genes, down-regulation disease resistance genes and activation of host antioxidant system contributed to a susceptible response. Activation of Jasmonic acid (JA) pathway and protease inhibitors was due to wounding during nematode migration and feeding. Nematode infection suppressed ethylene (ET) and salicylic acid (SA) signalling pathway hindering SA/ET responsive genes involved with defense. Induction of auxin biosynthesis genes, regulation of cytokinin levels and up-regulation of transporter genes facilitated of nematode feeding sites (NFSs) initiation. The regulation of several families of transcription factors (TFs) in the plant, such as WRKY, GRAS, ERF BHLH and MYB, was affected by RKN infection disrupting plant defense signalling pathways. This clearly suggest that TFs played an indispensable role in physiological adaptation for successful RKN disease development. This genome-wide analysis revealed the molecular regulatory networks in potato roots which are successfully manipulated by RKN. Being the first study analysing transcriptome profiling of RKN diseased potato, it will provide unparalleled insight into the mechanism underlying disease development.
Sistema de Videomonitoramento com Identificação de Suspeitos Utilizando Biometria Facial

This work aims to use a convolutional neural network to automate the process of identifying suspicious individuals in residential environment. The faces of unknown individuals are captured the saved in the system. An accuracy of 91.84% was obtained after the experiments, which used a database containing videos simulating the access of individuals to two different internal environments. Resumo: Este trabalho tem como objetivo utilizar uma rede neural convolucional para automatizar o processo de identificação de indiv́ıduos suspeitos em um ambiente residencial. As faces de indiv́ıduos desconhecidos são capturadas e registradas pelo sistema. Uma acurácia de 91,84% foi obtida após a realização de experimentos que utilizaram uma base de dados contendo v́ıdeos simulando o acesso de indiv́ıduos a dois ambientes internos diferentes.
Computational studies of non-viscous and viscous fluid flows

This Bachelor’s Degree Thesis consists on a computational study of non-viscous andviscous fluid flows interacting with different external conditions and solid objects.The governing equations of fluid dynamics are Navier-Stokes equations. NS equa-tions are differentiate partial equations that are transformed into numerical expres-sions that can be computed.Simulations with the computer are runned for different reference cases for which aprevious solution has been obtained analytically or by researchers, beforehand.The principles, solvers and methods used to achieve a solution for the simulationscan be extrapolated to more complex problems.
PREVALENCE OF CARDIAC AUTONOMIC NEUROPATHY IN TYPE 2 DIABETES MELLITUS

BACKGROUND Diabetic neuropathy, a set of clinical syndrome sometime silent and undetected, may be single or combined with signs which are nonspecific, insidious and slow and often diagnosed by exclusion. Neurologic complications occur equally in all types of diabetes – type I, type II and all other types of diabetes. MATERIALS AND METHODS This study aimed at assessing the prevalence of Cardiac Dysautonomia in type 2 diabetic individuals using conventional testing methods and by using Ansiscope. RESULTS ‘At diagnosis’ 68.8% were CAN positive by ansiscope and 81.2% by conventional method. In individuals with a duration of 1 5 years, 82% and 88% tested positive for autonomic dysfunction by ansiscope and conventional method respectively. CONCLUSION Diabetics for more than 5 years were tested 100% positive for autonomic dysfunction by either of the methods.
Short-Term Outcome of Balloon Angioplasty of Discrete Coarctation of Aorta

Introduction: Balloon angioplasty has been proposed as a an alternative way to surgery in primary treatment of aortic coarctation(CoA) for both children and infants. Objective: The purpose of this study is to assess the immediate and intermediate term effectiveness and safety of balloon angioplasty in infants and children with native discrete membranous CoA. Patients and methods: Forty consecutive patients with native discrete coarctation of the aorta were treated with balloon angioplasty. They were 8 infants and 32 children; with ages ranged from 2 months to 10 years and all weighted below 35 Kg. All patients were clinically evaluated immediately after and at 6 to 12 months and 18 to 24 months after the procedure. Follow up data were collected and Doppler echocardiography was done before intervention to confirm diagnosis and to plan management and post interventional to follow-up patients and estimate the outcome and complications. Results: Immediate successful relief of native Co A was obtained in 92.5% of the population study, while 7.5% recorded immediate suboptimal results with pressure gradient above 20mmHG. The peak systolic gradient across the coarcted segment was reduced significantly with 82.5% immediately after balloon angioplasty,75% and 73.2% at the end of first and second follow up period respectively. Pressure gradient decreased significantly from 57±15.7 mmHg before balloon angioplasty to 14.23±11.30mmHg 9 to 12 months after, but it was increased slightly to reach 15.15±11.80 mmHg at the end of the second year. The systolic ascending aortic pressure decreased significantly (19%) and the systolic descending aortic pressure increased significantly (11.4%) at the end of the study. Recoarctation occurred in17.5% at the end of the 1st year and balloon angioplasty was repeated for all patients successfully. At the end of the 2nd year restenosis was evidenced in 10% of the whole study population. Aneurysm formation at the site of coarcted segment occurred in (5%). Conclusion: Balloon angioplasty is an effective and safe alternative to surgery for treatment of Co A in infants older than 2 months and children10 years of age or younger.
A Cost-Utility Analysis of Switching from Reference to Biosimilar Infliximab Compared to Maintaining Reference Infliximab in Adult Patients with Crohn’s Disease

Abstract Background and Aims Lower-cost biosimilar infliximab may address affordability concerns in the treatment of adults with Crohn’s disease (CD), however, evidence regarding the cost-effectiveness of switching from reference to biosimilar is warranted. The aim of this research was to assess the incremental cost of switching from treatment with reference infliximab to biosimilar compared with maintaining reference infliximab in adults with CD per quality-adjusted life year (QALY) gained. Methods A probabilistic cohort Markov model with 8-week cycle lengths was constructed to estimate the incremental costs and effects of switching over a 5-year time horizon from a public payer perspective. Base-case clinical inputs were obtained from NOR-SWITCH subgroup analyses and other published trials. Costs were obtained from Canadian sources. A total of 10,000 simulations were run. Sensitivity analysis was used to test the robustness of the results to variations in uncertain parameters. Results Switching to biosimilar infliximab was less costly but also less effective with incremental savings of $46,194 (95% confidence interval [CI]: $42,420, $50,455) and a loss in QALYs of −0.13 (95% CI: −0.16, −0.07). Eighty-three per cent of the simulations demonstrated incremental cost savings and an incremental loss of effectiveness. The model was sensitive to differences in rates of disease worsening between reference and biosimilar infliximab. Conclusions While biosimilar infliximab is associated with incremental savings for patients on maintenance therapy who are switched from reference infliximab, funding decision makers must decide whether a small loss of effectiveness is justified. Further evidence will help to inform reimbursement policy.
Modeling and identification of the hysteresis nonlinear levitation force in HTS maglev systems

High-temperature superconducting (HTS) maglev has great potential in the field of high-speed transportation due to its capability for passive stabilization. The levitation force between the bulk HTSs and the permanent magnet guideway is a significant parameter relating to operational safety and comfort. This force has an obvious hysteresis nonlinear characteristic, which can be represented by nonlinear stiffness and damping. The stiffness and the damping are functions of vertical displacement and velocity, respectively. The vibration velocity of a HTS maglev vehicle can at times exceed 100 mm s−1, but the existing levitation force test methods are almost quasi-static. These methods are unable to accurately measure the damping characteristic of the maglev system. In this paper, a viscoelasticity model is introduced to describe the dynamic force. The parameters in the model are identified using the least square method based on the vibration response of the HTS maglev system. Meanwhile, the effectiveness of the model and identification method are tested by numerical simulations. The hysteresis loops derived from the motion theory coincide with the practical ones. Finally, the method is applied to identify the parameters of hysteresis nonlinear levitation force in a previous experiment with dampers. Based on the established hysteretic model, the dynamic characteristics of the HTS maglev system can be well presented.
Cuff-Less and Continuous Blood Pressure Monitoring: A Methodological Review

Blood pressure (BP) is one of the most important monitoring parameters in clinical medicine. For years, the cuff-based sphygmomanometer and the arterial invasive line have been the gold standards for care professionals to assess BP. During the past few decades, the wide spread of the oscillometry-based BP arm or wrist cuffs have made home-based BP assessment more convenient and accessible. However, the discontinuous nature, the inability to interface with mobile applications, the relative inaccuracy with movement, and the need for calibration have rendered those BP oscillometry devices inadequate for next-generation healthcare infrastructure where integration and continuous data acquisition and communication are required. Recently, the indirect approach to obtain BP values has been intensively investigated, where BP is mathematically derived through the “Time Delay” in propagation of pressure waves in the vascular system. This holds promise for the realization of cuffless and continuous BP monitoring systems, for both patients and healthy populations in both inpatient and outpatient settings. This review highlights recent efforts in developing these next-generation blood pressure monitoring devices and compares various mathematical models. The unmet challenges and further developments that are crucial to develop “Time Delay”-based BP devices are also discussed.
Identification of crack-like defect and investigation of stress concentration in coated bar

The first part of this work is devoted to the location of defects in a coated bar and the identification of their geometrical parameters. Using the methods of finite element modeling, ultrasonic non-destructive testing and machine learning technologies (artificial neural networks), the inverse problem of mechanics has been solved. A finite element model of ultrasonic wave propagation in a bar with a coating and an internal defect is constructed. Compared with previous works, the model used PML (Perfectly Matched Layer) structures, which suppress multiple reflections of the probe ultrasound pulse inside the bar and prevent signal noise. Based on the conducted numerical calculations of the finite element model, a data set was constructed. It contains the geometrical parameters of the defect and the corresponding amplitude-time characteristic of the ultrasonic signal. The architecture of a direct propagation neural network has been developed. The neural network was trained on the basis of previously processed data. As a result, on the basis of ultrasound data obtained from the outer surface of the bar, it is possible to restore the values of such defect parameters as depth, length and thickness. At the second stage, analytical-numerical technology for studying the stress intensity factor (SIF) at the crack tip is described using the example of the problem of a longitudinal internal crack of finite length located in an elastic strip reinforced with a thin flexible coating. The solution to this problem is based on the method of integral transformations, which made it possible to reduce it to a singular integral equation of the first kind with a Cauchy kernel, which is solved by the collocation method in the form of expansion in Chebyshev polynomials with a factor that explicitly takes into account a feature in the vicinity of the crack vertices. The latter allows you to directly find the SIF and evaluate the effect on it of various combinations of geometric and physical parameters of the problem.
Influence of low energy laser irradiation on the clinical treatment potential of adipose tissue-derived stem cells

Objective To investigate the effects of low level gallium aluminum arsenide (GaAlAs) laser irradiation on proliferation, cytokine secretion and adipogenic differentiation of cultured human adipose tissue-derived stem cells (hADSCs), and to find a safe and effective method for improving clinical treatment effect of ADSC. Methods The cultured hADSCs from human adipose tissue were treated by using 650nm GaAlAs laser irradiation at a single of 2, 4 and 8J/cm2 respectively. Cell proliferation was quantified by MTT assay, cytokine secretion was determined by ELISA, and adipogenic differentiation was examined by oil red staining respectively. In addition, the expression profiles of putative hADSC surface markers were determined by real-time PCR. Results MTT assay showed that treatment with GaAlAs laser irradiation at 4J/cm2 and 8J/cm2 (especially 4J/cm2) markedly promoted ADSCs proliferation from day 4 to day 6 after irradiation, when compared with the unirradiated group (P<0.05). ELISA results showed that the concentrations of VEGF, PDGF and TGF-βin culture supernatant were 287.5±15.2pg/ml, 36.0±0.7ng/ ml, and 292.6±10.5pg/ml when hADSCs were exposed to 4J/cm2 GaAlAs laser, and they were significantly higher than those of unirradiated group (145.3±21.6pg/ml, 26.7±0.6ng/ml and 130.6±6.0pg/ml, respectively, P<0.05). Quantitative PCR showed that the mRNA expression levels of cell surface marker CD13, CD29, CD44 and CD90 in hADSCs exposed to 4J/cm2 GaAlAs laser were 1.19, 22.05, 4.38 and 7.22 fold of those in unirradiated group (P<0.05). And the oil red staining revealed that GaAlAs laser irradiation could markedly accelerate the adipogenic differentiation of hADSCs (P<0.05). Conclusions Low energy laser irradiation is a simple, safe and effective method, which can enhance the proliferation, cytokine secretion and adipogenic differentiation of ADSCs, may help to improve the therapeutic effect of ADSCs by clinical transformation application. DOI: 10.11855/j.issn. 0577-7402.2016. 09.01
Waist-to-hip measurement ratio among dental students in urban areas

Background: Waist-to-hip ratio (WHR) is an anthropometric measure commonly used to characterize regional adiposity. WHR is a crude estimate of the relative amount of abdominal fat: Higher the hip girth compared to waist girth, the greater the proportion of abdominal fat. As early as the 1980s, several prospective epidemiological studies reported that WHR is a significant predictor of coronary heart disease and death. A large number of studies have since replicated these initial findings, with some reporting that WHR was a stronger predictor of myocardial infarction or mortality risk. Aims and Objectives: To evaluate the WHR in among students of the private dental college, to review the usefulness of waist circumference and WHR measures as predictors of non-communicable disease risk and to define the potential cut off points for public health action. Materials and Methods: A total of 70 young adults studying in private dental college were chosen for the study. Students with systemic illness were excluded from the study. The waist and the hip circumferences were measured. The results were recorded and tabulated. Results: The WHR calculated in students found to be significant in 64.28% of the students and it is not significant in 35.72% of the students and most of the students have an appropriate WHR. Conclusion: The research proves that most of the students studying in Saveetha Dental College were found to have normal WHR. The study will aid the physician in earlier identification of various systemic complications such as obesity, cardiovascular diseases by assessing the WHR.
Localized activation of ependymal progenitors induces EMT-mediated glial bridging after spinal cord injury

Unlike mammals, adult zebrafish undergo spontaneous recovery after major spinal cord injury. Whereas scarring presents a roadblock for mammalian spinal cord repair, glial cells in zebrafish form a bridge across severed spinal cord tissue to facilitate regeneration. Here, we performed FACS sorting and genome-wide profiling to determine the transcriptional identity of purified bridging glia. We found that Yap-Ctgf signaling activates epithelial to mesenchymal transition (EMT) in localized niches of ependymal cells to promote glial bridging and regeneration. Preferentially activated in early bridging glia, Yap is required for the expression of the glial bridging factor Ctgfa and for functional spinal cord repair. Ctgfa regulation is controlled by an injury responsive enhancer element that drives expression in early bridging glia after injury. Yap-Ctgf signaling activates a mesenchymal transcriptional program that drives glial bridging. This study revealed the molecular signatures of bridging glia and identified an injury responsive gene regulatory network that promotes spinal cord regeneration in zebrafish.
Évaluation de la pratique d'activité physique du patient coronarien ayant bénéficié de la réadaptation cardiaque

Objectifs : Evaluer chez les patients coronariens ayant beneficie de la readaptation cardio-vasculaire, l'evolution de la pratique de l'activite physique depuis l'accident cardiaque. Methodes : Vingt cinq patients ont repondu au score d'activite de Dijon lors de la troisieme semaine de readaptation cardio-vasculaire sur leur mode de vie avant l'accident cardiaque (phase 1) et six mois post-readaptation lors d'un entretien telephonique sur leur mode de vie actuel (phase 2). Le score moyen de la population a ete calcule, de meme que le nombre de personnes realisant 150 minutes d'activite physique moderee par semaine (preconisation A) et/ou au minimum 30 minutes d'activite physique au moins trois fois par semaine a l'annee (preconisation B). Resultats : Le score moyen de la population est passe de 13,64 ± 7,35 a la phase 1 a 20,56 ± 3,96 points a la phase 2. Deux patients en phase 1 respectaient la preconisation A contre dix en phase 2. Cinq patients realisaient la preconisation B en phase 1 contre treize en phase 2. Conclusions : Il semble y avoir une augmentation de la pratique de l'activite physique chez les patients coronariens ayant beneficie de la readaptation cardio-vasculaire.