Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Clopidogrel on Blood Flow through Stenosed Artery under Diseased Condition

Clopidogrel is a cholesterol-lowering drug it can help to prevent more plaque from forming. In this present model the effects of Clopidogrel on viscosity of blood has been obtained. This problem of non-Newtonian and non-linear blood flow through a stenosed artery is solved numerically where the non-Newtonian rheology of the flowing blood is characterized by the generalized Power-law and Bingham plastic fluid models. The proposed model are solved and closed form expressions for the blood flow characteristics namely, velocity profile, volumetric flow rate, pressure gradient, resistance to flow, wall shear stress and apparent viscosity are derived. The effects of various parameters entering into problem are discussed with the help of graphs. It has been found that the wall shear stress and resistance to flow and viscosity increases with the non-Newtonian behavior index of the blood as well as tube radius for constant value of the stenosis height for both fluid models but these increases are comparatively small in Power-law fluid model. It has been concluded that the patients entangled to cardiovascular diseases due to blood clots can prevent by giving the regular doses of Clopidogrel in order to dilute the blood. This lowers the blood viscosity. Clopidogrel would be more helpful in the functioning of diseased arterial circulation. This work may be help in diagnosis and treatment of cardiovascular disorders as well as people working in biomedical field.
Behavior and Mechanism of Cesium Biosorption from Aqueous Solution by Living Synechococcus PCC7002

Many efforts have focused on the adsorption of metals from contaminated water by microbes. Synechococcus PCC7002, a major marine cyanobacteria, is widely applied to remove metals from the ocean’s photic zone. However, its ability to adsorb cesium (Cs) nuclides has received little attention. In this study, the biosorption behavior of Cs(I) from ultrapure distilled water by living Synechococcus PCC7002 was investigated based on kinetic and isotherm studies, and the biosorption mechanism was characterized by Fourier-transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectrometry, and three-dimensional excitation emission matrix fluorescence spectroscopy. Synechococcus PCC7002 showed extremely high tolerance to Cs ions and its minimal inhibitory concentration was 8.6 g/L. Extracellular polymeric substances (EPS) in Synechococcus PCC7002 played a vital role in this tolerance. The biosorption of Cs by Synechococcus PCC7002 conformed to a Freundlich-type isotherm model and pseudo-second-order kinetics. The binding of Cs(I) was primarily attributed to the extracellular proteins in EPS, with the amino, hydroxyl, and phosphate groups on the cell walls contributing to Cs adsorption. The biosorption of Cs involved two mechanisms: Passive adsorption on the cell surface at low Cs concentrations and active intracellular adsorption at high Cs concentrations. The results demonstrate that the behavior and mechanism of Cs adsorption by Synechococcus PCC7002 differ based on the Cs ions concentration.
Walking through life with cerebral palsy: reflections on daily walking by adults with cerebral palsy

ABSTRACT Purpose: Walking is a major target in childhood physiotherapy for children with cerebral palsy (CP). Little information exists on the importance or value of walking when these children grow up. The aim of this study was to explore personal reflections on daily walking by adults with CP. Method: Semi-structured individual interviews were conducted and analysed with systematic text condensation, a four-step thematic cross-case analysis. Results: Eight ambulatory adults (26–60 years, four women and four men) with CP were interviewed. Almost all had experienced deteriorated walking ability in adulthood and reported that walking was restricted and affected by intrinsic features, such as pain, fatigue, reduced balance and fear of falling. Extrinsic features such as being looked at due to walking abnormality and environmental factors, such as seasonal changes affected their free walking and was common. Some had accepted using mobility aids for energy conservation. Conclusions: Both intrinsic and extrinsic factors influence walking in adults with CP. Reflections by the adults with CP suggest these features may reduce participation in public spaces and potentially increase acceptance and use of mobility aids.
Draft Genome Sequence of the Yeast Rhodotorula sp. Strain CCFEE 5036, Isolated from McMurdo Dry Valleys, Antarctica

A draft genome sequence was assembled and annotated of the basidiomycetous yeast Rhodotorula sp. strain CCFEE 5036, isolated from Antarctic soil communities. The genome assembly is 19.07 megabases and encodes 6,434 protein-coding genes. The sequence will contribute to understanding the diversity of fungi inhabiting polar regions. ABSTRACT A draft genome sequence was assembled and annotated of the basidiomycetous yeast Rhodotorula sp. strain CCFEE 5036, isolated from Antarctic soil communities. The genome assembly is 19.07 megabases and encodes 6,434 protein-coding genes. The sequence will contribute to understanding the diversity of fungi inhabiting polar regions.
Modelling and analysis of barriers to implementation social sustainability practices using MICMAC approach

The objective of this study is to evaluate the crucial barriers to the successful implementation of social sustainability initiatives. We have used two distinctive modelling approaches to investigate the contextual relationship between the key barriers and to rank them concerning their importance. We identified barriers through literature review and data collected from senior managers from four manufacturing industries. Interpretative structural modelling (ISM) approach is used to develop a hierarchical structure for analyzing the interactions among the key barriers. MICMAC (Matriced' Impacts Croise's Multiplication Appliquée a UN Classement) method is then used to examine the driving and the dependence power of key barriers. ISM model highlights that lack of involvement of operational staff in planning and lack of supportive institutional policies are the key barriers. These barriers that lead to lack of understanding customer needs and exchange of information and lack of managerial capabilities for implementation and adaptation to new heath and safety practices. Whereas, MICMAC analysis revealed lack of knowledge on resource management and lack of trained people drive the other barriers. This suggests that firm make social sustainable development performance by addressing these linkages barriers and driving barriers in manufacturing firms. Production managers, supply chain designers and policymakers can utilise the findings of the present study.
Structure and evolution of transiting giant planets: a Bayesian homogeneous determination of orbital and physical parameters

We present a Bayesian homogeneous determination of orbital and physical parameters of a large sample of 211 giant transiting planets with masses between 0.1 and 24 MJup and precision on mass estimates better than 30%. We analyse new high-precision radial velocities for forty-five of them obtained with the HARPS-N@TNG spectrograph to improve and, in some cases, to revise the measure of their orbital eccentricity, and to search for long-period companions. From the updated orbital eccentricities we put constraints on the modified tidal quality factors of giant planets and their host stars. Our comprehensive study 1) allows for improved understanding of orbital evolution and migration scenarios for giant planets, and 2) provides the much needed benchmark statistics for thorough investigations of the diversity of giant planet densities and interior structures.
Circulating guanylyl cyclase C (GCC) mRNA is a reliable metastatic predictor and prognostic index of colorectal cancer

Background Currently, few specific biomarkers or standard cutoff values are available for circulating tumor cells (CTCs) detection and survival prediction in patients with early stage colorectal cancer (CRC). Guanylyl cyclase C (GCC) presents as a specific expression in intestinal tumor cells and during their metastases, indicating its potential application as a metastatic predictor of CRC. Methods The circulating GCC mRNA of 160 colorectal cancer patients at stage I–III was detected via quantitative real-time (qRT)-PCR in our study, and the correlation of GCC mRNA level with tumor metastasis and long-term survival was explored. Results GCC mRNA was found to be positive in 43 out of 160 CRC patients and negative in ten healthy controls. It was found that GCC mRNA over the baseline (>100 copies/µL and 200 copies/µL) showed a significant correlation with disease-free survival (DFS) and overall survival (OS) in the stage II subgroup. It was further revealed that GCC mRNA over 300 copies/µL or higher than the median value of copy numbers was significantly correlated with reduced OS and DFS in CRC patients. A nomogram model based on variables including GCC mRNA copy number was established for predicting the OS of CRC patients (AUC =0.98). Conclusions Circulating GCC mRNA over baseline is a reliable predictor for tumor metastasis and can be a prognostic index in CRC patients.
Software Support For Programming Language Tutorials

— Tutorials are indispensible for many university courses, such as computer programming. The paper contributes to the shift from the tutorial organization with one student solving a problem and others watching to the setting when each student solves his/her individual problems assisted by a computer and the instructor. The research resulted in creation of a computer-assisted tutorial system for the course of programming languages. The system uses a database of programming problems. It aids an instructor in preparing and delivering tutorials. It provides each student with an environment for problem selection, its solution and solution verification. The system has some special features. A problem requires writing a programming code. A student has to write only a fragment of the complete program. The context of the fragment is added by the system automatically. The system operates in a local network which connects personal computers of students and the instructor’s portable computer. The first version of this computer system was successfully tested at the Kharkov National University of Radio Electronics.
Author's personal copy Development of a high-efficiency hydrogen generator for fuel cells for distributed power generation

A collaborative effort between Intelligent Energy and Cal Poly Pomona has developed an adsorption enhanced reformer (AER) for hydrogen generation for use in conjunction with fuel cells in small sizes. The AER operates at a lower temperature (about 500 C) and has a higher hydrogen yield and purity than those in the conventional steam reforming. It employs ceria supported rhodium as the catalyst and potassium-promoted hydrotalcites to remove carbon dioxide from the products. A novel pulsing feed concept is developed for the AER operation to allow a deeper conversion of the feedstock to hydrogen. Continuous production of near fuel-cell grade hydrogen is demonstrated in the AER with four packed beds running alternately. In the best case of methane reforming, the overall conversion to hydrogen is 92% while the carbon dioxide and carbon monoxide concentrations in the production stream are on the ppm level. The ratio of carbon dioxide in the regeneration exhaust to the one in the product stream is on the order of 10. a 2010 Professor T. Nejat Veziroglu. Published by Elsevier Ltd. All rights reserved.
Comparison of Electromechanical Delay during Ventricular Tachycardia and Fibrillation under Different Conductivity Conditions Using Computational Modeling

Electromechanical delay (EMD) is the time interval between local myocyte depolarization and the onset of myofiber shortening. Previously, researchers measured EMD during sinus rhythm and ectopic pacing in normal and heart failure conditions. However, to our knowledge, there are no reports regarding EMD during another type of rhythms or arrhythmia. The goal of this study was to quantify EMD during sinus rhythm, tachycardia, and ventricular fibrillation conditions. We hypothesized that EMD under sinus rhythm is longer due to isovolumetric contraction which is imprecise during arrhythmia. We used a realistic model of 3D electromechanical ventricles. During sinus rhythm, EMD was measured in the last cycle of cardiac systole under steady conditions. EMD under tachycardia and fibrillation conditions was measured during the entire simulation, resulting in multiple EMD values. We assessed EMD for the following 3 conduction velocities (CVs): 31 cm/s, 51 cm/s, and 69 cm/s. The average EMD during fibrillation condition was the shortest corresponding to 53.45 ms, 55.07 ms, and 50.77 ms, for the CVs of 31 cm/s, 51 cm/s, and 69 cm/s, respectively. The average EMD during tachycardia was 58.61 ms, 58.33 ms, and 52.50 ms for the three CVs. Under sinus rhythm with action potential duration restitution (APDR) slope 0.7, the average EMD was 66.35 ms, 66.41 ms, and 66.60 ms in line with the three CVs. This result supports our hypothesis that EMD under sinus rhythm is longer than that under tachyarrhythmia conditions. In conclusion, this study observed and quantified EMD under tachycardia and ventricular fibrillation conditions. This simulation study has widened our understanding of EMD in 3D ventricles under chaotic conditions.
Stress and visceral pain: a review

Aim: To review the various psychological theories of stress, to better understand how this takes place in the question of visceral pain, in particular, abdominal pain. Procedure: Systematic review of significant articles on stress and visceral pain, in both the child and the adult. Results: A great influence of the events suppliers of stress in the visceral pain is demonstrated. However, the link of causality cannot be demonstrated. Conclusion: The clinical approach of visceral pain is complex. Therefore, it is open toward complementary therapeutic ways, which seem to bring satisfaction in many situations. To cite this journal: Douleur analg. 23 (2010).
Exploratory review of the state of the art on the impact of implementation in SMEs: Case study in the environmental management system

The implementation of environmental management systems in SMEs has had an imminent importance for compliance with regulations and regulations, which affects the decision making of organizations, in the course of the activities of their corporate purpose. Analyzing the influence of these factors will establish important elements that will affect organizational behavior. Through the review of the state of knowledge about the impact of the implementation of environmental management systems and its impact on other countries, which serves as a support to understand the dynamics considered as a management system in companies.
RAPID APPROXIMATION OF FUNDAMENTAL PARAMETERS AND SCENARIOS IN GALACTIC OPEN CLUSTER STUDIES

Since electronic sheet feel at ease over many astronomy research fields and open cluster photometric study is one of these, an Excel + VBA application that can be useful to obtain, very rapidly, cluster fundamental parameters and scenarios is presented. To provide minimal information on this application are summarized briefly some important, even if non exhaustive points, applying this code to open clusters IC 2581 and Ngc 129. Particularly are illustrated first, a photometric analysis and solution for IC 2581 and after, using Ngc 129, some arguments related to stellar variability inside open clusters.
Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance

Background Disruption of β-cell insulin secretion and viability caused by excessive ethanol consumption increases type 2 diabetes mellitus (T2DM) pathogenesis risk. Fibroblast growth factor 21 (FGF21) plays a significant role in regulating lipid and glucose homeostasis. Recently, FGF21, best known for its role in lipid and glucose homeostasis regulation, and its obligate co-receptor β-klotho have been shown to inhibit ethanol ingestion and metabolism. It remains unclear whether heavy ethanol intake modulates islet FGF21 expression and function. This study investigated the relationship between ethanol exposure, FGF21, and islet function in vivo/ex vivo islet and in vitro cell models. Methods Mice were gavaged with 3.5 g/kg ethanol or saline for 1–3 weeks (long-term exposure). Human MIN6 cells and isolated islets were cultured and treated with 80 mM ethanol for 24 h (short-term exposure) to mimic excessive ethanol consumption. We applied the oral glucose tolerance test (OGTT), blood glucometry, enzyme-linked immunosorbent assay (ELISAs) for insulin and FGF21, glucose stimulated insulin secretion (GSIS) testing, reverse-transcription (RT)-polymerase chain reaction (PCR), and western blot experiments. Results Long-term ethanol treatment induced FGF21 resistance in mouse pancreatic islets. Moreover, ethanol exposure damaged insulin secretory ability and glucose homeostasis. In vitro and ex vivo experiments showed that short-term ethanol treatment upregulated the expression of FGF21 signaling pathway-related genes and proteins, without affecting β-cell survival or function. Conclusions Long-term ethanol consumption induces FGF21 resistance-mediated pancreatic β-cell dysfunction, and thus diabetes pathogenesis risk.
Assessment of Vitamin D Level in Sudanese Post Renal Transplant Patients – Khartoum State

Background: Insufficient levels of Vitamin D and abnormal metabolism of calcium and phosphate are common problems among post renal transplant patients and general population. It creates a universal health apprehension since vitamin D deficiency is associated with many diseases. Vitamin D supplements after transplantation has been suggested to prevent risk of bone loss. Tacrolimus (FK506) and cyclosporine A (CsA), two kinds of immunosuppressive drugs, have been widely used in the field of renal transplantation. As triple-immunosuppressive regimen, FK506-Mycophenolate Mofetil (MMF)- Prednisone (Pred) or CsA-MMF-Pred was applied mainly depended on doctors’ experience and drug economics. However, there was no any detail treatment guidelines for the drug selection. The objectives of this study are to assess the prevalence of Vitamin D deficiency in the Sudanese renal transplant patients, compared with controls and study the role of immunosuppressive drugs. Methodology: This study was conducted in kidney transplantation centers to investigate the levels of Vitamin D, Parathyroid hormone, calcium and phosphorus and the effect of immunosuppressive drug on vitamin D metabolism in Sudanese renal-transplantation patients, Khartoum state during March 2017. The control group (n=40) matched for age and sex with renal post-transplants patients group (n=40). Results: In our study, 80 participants, 26 out of 40 individuals (65%) were males and 14 (35%) were females in each study group (patient and control). The mean age was 42.25±14.46 years in kidney transplant patients and 42.15±14.66 years in control group. Inadequate serum 25-hydroxyvitamin D (vitamin D level: 50 – 72.5 nmol/L) was seen in 17.5% of transplant patients and 35% of the controls, 72.5% of patients had vitamin D deficiency (level of vitamin D < 50 nmol/L) and 5% of control group. There was significant difference in vitamin D concentrations between the two groups (P value < 0.05). Low vitamin D concentrations were associated with increased Parathyroid Hormone (PTH) levels (P value < 0.05). Tacrolimus (FK-506) was associated with higher risk of deficiency. Conclusion: Vitamin D deficiency is prevalent among Sudanese kidney transplant patients; there were insufficient and deficient status among healthy control too, due to lack of exposure to sun despite being in a region with high UV light or poor diet. They may need vitamin D supplements for stabilization of serum vitamin D and improving the diet and life style.
Bio-Synthesis and Characterizations of Magnetic Iron Oxide Nanoparticles Mediated By Iraq Propolis Extract

Background: The present study report for the first time the most eco-friendly, safety, less toxic method for the synthesis of iron oxide nanoparticles using bees products ,the propolis. Biosynthesis of iron oxide nanoparticles (IONPs) using natural materials with less expensive and less harmful effects is of interest in the present time, therefore, Material and Method: The formation of IONPs from two types of iron salts using propolis water extract was evaluated. The formed iron oxide nanoparticles was illustrated by changes in color from brown to black color due to bioreduction of iron salts by propolis extract that is rich of poly phenols. The synthesized magnetite nanoparticles were characterized by UV – Vis absorption spectroscopy, FTIR, XRD and SEM Techniques. Result: The involvement of propolis phenol groups in iron oxide nanoparticles synthesis, is evident from the results of the FTIR. The XRD results depending on the latency of the particles at 2θ revealed the average particle size of magnetic NP formed from mixture of FeCl3 and FeCl2 are found to be in the range 31,714 – 46,20nm, and with SEM of these nanoparticles showed an agglomeration Conclusion, In conclusion the biosynthesis of iron oxide using propolis water extract consider as effective one step rout for reduction of iron salts to form iron oxide and it may be the future way for eco-friendly, safety, less toxic method for the synthesis of iron oxide nanoparticles. Keyword: Biosynthesis, Iron Oxide Nanoparticles, Magnetite, Propolis -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 23-08-2017 Date of acceptance: 19-12-2017 -------------------------------------------------------------------------------------------------------------------------------------Figure-1: Steps for biosynthesis of Iron oxide Nanoparticles using Iraq propolis