Miracle-dz/UniFAR-FTUs huggingface dataset:
A prospective controlled evaluation of Class II division 1 malocclusions treated with fixed lingual mandibular growth modificator.

OBJECTIVE To assess the net dentofacial effects of the fixed lingual mandibular growth modificator (FLMGM). MATERIALS AND METHODS The study sample comprised 38 patients with Class II/1 malocclusion and retrognathic mandible. All were in the pubertal growth spurt. Whereas FLMGM was applied to the treatment group (n=21, mean age=13.2 years), no treatment was performed on the control group (n=17, mean age=12.5 years). Skeletal and dentoalveolar changes were assessed on digital lateral cephalograms obtained at the beginning and end of the treatment/observation period of 8 months. Paired and independent t-tests were used to assess the differences within and between groups. RESULTS Maxillary growth was not affected by FLMGM treatment, which resulted in a significant overjet reduction of 4.1 mm, an increase in total mandibular length (Co-Gn) of 2.3 mm, chin advancement of 1.6°, and upper incisor retroclination of 4.0°. A reduction of 2.4° in ANB was largely due to an increase of 1.8° in SNB. Favorably, the lower incisors were obviously retroclined by 4.5°. The changes in the vertical skeletal relationships were negligible. CONCLUSION FLMGM was effective in treating growing Class II/1 patients and produced favorable dentofacial effects, with the matched untreated sample showing minimal changes. Lower incisor retroclination was a benefit of FLMGM treatment.
Relationship between plasma cortisol and peak expiratory flow rat in exercise-induced asthma and the effect of sodium cromoglycate.

1. The changes in peak expiratory flow rate (PEF) and plasma cortisol were studied in relation to a 6 min period of treadmill running in six normal and eighteen asthmatic subjects. Of the asthmatics patients, five were not receiving treatment with steroids, six were receiving low doses of steroids (under 7·5 mg of prednisone daily) and seven were receiving high doses of steroids (over 7·5 mg of prednisone daily) at the time of study. 2. All subjects were studied twice within 1 week at similar times of day, once after premedication with sodium cromoglycate (SCG) and once after a placebo. 3. Resting PEF and plasma cortisol did not differ between placebo and SCG tests. 4. No change in PEF occurred as a result of exercise in the control subjects. The asthmatic patients developed post-exercise bronchoconstriction which was partly prevented by SCG but was not affected by steroids. 5. Plasma cortisol rose after exercise in the asthmatic subjects but not in the control subjects. The rise may have been related to the stress of exercise-induced asthma. SCG had no significant effect on plasma cortisol after exercise.
“The Route of Unification” – A challenge to visit Alba Iulia and identify historical facts that led to the Great Unification of Romania. Alba Iulia: 1st December 1918

This volume is the result of the activities developed in the COS-TOUR-2015 DIVERTIMENTO project. The book presents the pilot project for Romania as well as the cultural participative route developed in this project. By interfering the pilot project and the associated tourist route in a single volume, a better understanding of the message sent to the tourism consumer is ensured. The main message is that (re) discovering facts and events from the past can bring benefits to future generations. Secondly, emphasis is placed on the importance of digitization of cultural heritage consumption, which has become the predominant model of the present and the future in cultural services, without replacing the on-site consumption pattern with a virtual one, representing only a better way to combine knowledge with on-site experience. Through this approach, we consider that cultural assets become attractive to new generations, allow the revival of this economic sector and a diversification of local services associated with tourism consumption, boosting the innovation capacity of tourism and associated services entrepreneurs, especially SMEs. In 2018, Romania is celebrating 100 years since the state unification as Modern Romania. The theme of the pilot project highlights the history route of actions, efforts and achievements to develop and recognize the Romanian State, finally stated by Unification Act on the 1st of December 1918 and consolidated by King Ferdinand’s Coronation in November 1922. With this touristic product we try to rediscover and reveal to the audience less known heritage assets and stories related to the main events regarding the process of establishing the modern state of Romania in Alba Iulia citadel and surroundings, in order to promote another face of Alba Iulia as heritage depositary.
21 Microbiota and Allergy : From Dysbiosis to Probiotics

The update theory of hygiene implicates the gut microbiota in the increasing prevalence of allergy. Indeed, changes have been observed in the establishment of the gut microbiota over the last fifteen years, and dysbiosis has been demonstrated in allergic subjects by numerous clinical studies comparing the microbiota in subjects from countries with high and low prevalence of allergy, or subjects with or without allergic diseases. These results support the use of proand prebiotics to treat or prevent allergic diseases; however, randomized controlled trials, mainly concerning atopic dermatitis, rhinitis and asthma, provide conflicting data. The mechanism of action of probiotics has not been elucidated. Nevertheless, it appears that lactobacilli and bifidobacteria may mediate immune responses in a strain-specific way, and the interactions involved seem to include dendritic cells and detection of microbe-associated molecular patterns. Although these functional foods are promising, numerous issues, including the bacterial strains and doses to use, remain to be determined.
Factors influencing work-life balance among married women employees in Putra Specialist Hospital Melaka / Nurul Nabila Azman

In today’s world, the concept “work-life balance” is considered to be one of the major issues that play an important role in organizational success. However, work-life balance is seen differently in different society. This paper aims to find out the reasons, which create work-life imbalance. Nowadays, a female employee faces more difficulties to balance between work and life than a male employee. This study focuses on married women employees in non-clinical departments. This study has been conducted based on primary research where a sample of 44 married women employees from different organizations is selected. Moreover, as for the sampling method in this study the researcher has use a non-probability sampling which is a convenience sampling as a sampling technique. Questionnaire was taken to reveal the factors that lead to the reason on an imbalance work-life. The study shows that the factors for which female employees are facing trouble to maintain a work-life balance are mostly because of family, work overload, working hours and work environment. The finding of the study focuses on formulating a structured guideline for the company so that the above mentioned factors can be omitted and female employees can balance their professional and personal life to get a better life in the future.
Seminal Fluid Drives Expansion of the CD4+CD25+ T Regulatory Cell Pool and Induces Tolerance to Paternal Alloantigens in Mice1

Abstract T regulatory (Treg) cells are implicated in maternal immune tolerance of the conceptus at implantation; however, the antigenic and regulatory signals controlling Treg cells in early pregnancy are undefined. To examine the role of male seminal fluid in tolerance induction, the effect of exposure to seminal fluid at mating on responsiveness to paternal alloantigens was examined using paternal tumor cell grafts and by delayed-type hypersensitivity (DTH) challenge on Day 3.5 postcoitum. Exposure to seminal fluid inhibited rejection of paternal tumor cells, independently of fertilization and embryo development, while seminal fluid from major histocompatability complex (MHC)-dissimilar males was less effective. Similarly, mating with intact males suppressed the DTH response to paternal alloantigens in an MHC-specific fashion. Excision of the seminal vesicle glands diminished the tolerance-inducing activity of seminal fluid. Mating with intact males caused an increase in CD4+CD25+ cells expressing FOXP3 in the para-aortic lymph nodes draining the uterus, beyond the estrus-associated peak in cycling mice. The increase in CD4+CD25+ cells was abrogated when males were vasectomized or seminal vesicles were excised. Collectively, these data provide evidence that exposure to seminal fluid at mating promotes a state of functional tolerance to paternal alloantigens that may facilitate maternal acceptance of the conceptus at implantation, and the effects of seminal fluid are likely to be mediated by expansion of the Treg cell pool. Both seminal plasma and sperm components of the seminal fluid are necessary to confer full tolerance and elicit the Treg cell response, potentially through provision of immune-deviating cytokines and antigens, respectively.
A Discourse Analysis - Determining the Storyboard Assets of Indonesian Environmental Public Service Animation Scripts

: An animation can be categorized as a good media if it is created through an elaborative storyboard-making procedure. The most important thing in the storyboard production is making the items (assets) that will be animated based on the script. In other words, the script must contain some content words (e.g. bed, king, table, etc.) that will be the basics on shaping the assets. Therefore, the advanced scanning process of the content words needs to be taken into account in order to make the storyboard-making process quicker. Based on this background, this research paper elaborates a syntactic discourse analysis, in which a mood classification as a systemic functional grammar tool also plays a role in order to find the content words from the script. After examining the script in that manner, the content words were interpreted as visual products. This research paper employed ten 2017 Indonesian environmental public service animation scripts as the data. The further attempt will lead into assessing the possibility of making a program system for creating assets visualization.
Hypoxia‐induced expression of bradykinin type‐2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis

Bradykinin receptors are differentially expressed in the coronary vascular endothelium of rat and human hearts during the pathogenesis of heart failure, but the mechanisms responsible for this regulation have remained vague. Here we show by quantitative real‐time PCR, Western blot analysis, and immunohistochemistry, that hypoxia triggers the expression of bradykinin type‐2 receptors (BK‐2Rs) in cultured human coronary artery endothelial cells (HCAECs), in isolated rat cardiac microvascular endothelial cells (RCMECs), and in rat hearts subjected to ligation of the left anterior descending coronary artery. Mild hypoxia (5% O2) induced a fourfold temporal increase in BK‐2R mRNA expression in HCAECs, which was also observed at the protein level, whereas severe hypoxia (1% O2) slightly inhibited the mRNA expression of BK‐2Rs. In addition, HOE‐140, a BK‐2R antagonist, inhibited mRNA and protein expression of BK‐2Rs. The BK‐2Rs induced by mild hypoxia were biologically active, that is, capable of inducing intracellular production of nitric oxide (NO) upon activation of HCAECs with bradykinin (BK), a response attenuated by HOE‐140. In rat hearts recovering from myocardial infarction, BK‐2Rs were upregulated in the endothelium of vessels forming at the border zone between fibrotic scar tissue and healthy myocardium. Furthermore, in an in vitro wound‐healing assay, RCMEC migration was increased under mild hypoxic culture conditions in the presence of BK and was attenuated with HOE‐140. Our present results show that mild hypoxia triggers a temporal expression of functional BK‐2Rs in human and rat endothelial cells and support a role for BK‐2Rs in hypoxia‐induced angiogenesis. J. Cell. Physiol. 221: 359–366, 2009. © 2009 Wiley‐Liss, Inc.
Probabilistic models in noisy environments : and their application to a visual prosthesis for the blind/

In recent years, probabilistic models have become fundamental techniques in machine learning. They are successfully applied in various engineering problems, such as robotics, biometrics, brain-computer interfaces or artificial vision, and will gain in importance in the near future. This work deals with the difficult, but common situation where the data is, either very noisy, or scarce compared to the complexity of the process to model. We focus on latent variable models, which can be formalized as probabilistic graphical models and learned by the expectation-maximization algorithm or its variants (e.g., variational Bayes). After having carefully studied a non-exhaustive list of multivariate kernel density estimators, we established that in most applications locally adaptive estimators should be preferred. Unfortunately, these methods are usually sensitive to outliers and have often too many parameters to set. Therefore, we focus on finite mixture models, which do not suffer from these drawbacks provided some structural modifications. Two questions are central in this dissertation: (i) how to make mixture models robust to noise, i.e. deal efficiently with outliers, and (ii) how to exploit side-channel information, i.e. additional information intrinsic to the data. In order to tackle the first question, we extent the training algorithms of the popular Gaussian mixture models to the Student-t mixture models. the Student-t distribution can be viewed as a heavy-tailed alternative to the Gaussian distribution, the robustness being tuned by an extra parameter, the degrees of freedom. Furthermore, we introduce a new variational Bayesian algorithm for learning Bayesian Student-t mixture models. This algorithm leads to very robust density estimators and clustering. To address the second question, we introduce manifold constrained mixture models. This new technique exploits the information that the data is living on a manifold of lower dimension than the dimension of the feature space. Taking the implicit geometrical data arrangement into account results in better generalization on unseen data. Finally, we show that the latent variable framework used for learning mixture models can be extended to construct probabilistic regularization networks, such as the Relevance Vector Machines. Subsequently, we make use of these methods in the context of an optic nerve visual prosthesis to restore partial vision to blind people of whom the optic nerve is still functional. Although visual sensations can be induced electrically in the blind's visual field, the coding scheme of the visual information along the visual pathways is poorly known. Therefore, we use probabilistic models to link the stimulation parameters to the features of the visual perceptions. Both black-box and grey-box models are considered. The grey-box models take advantage of the known neurophysiological information and are more instructive to medical doctors and psychologists.
Sharing and fairness in development

Issues of sharing and fairness pervade human life. They are a central piece of the human social mind puzzle. From a developmental perspective, natural observations of family life show that more than 80% of all conflicts among young siblings revolve around issues of possession and resource distribution (Dunn, 1988). Looking at political history, the same is true for all major conflicts among adults across cultures and since the ancestral time. So, what is the psychology behind such recurrent sources of conflicts and group disharmony? What mechanisms allow humans to resolve recurrent conflicts around possession, values, and resource distribution? Aside from the sheer power of coercion attached to Darwinian selection and other lion’s share principles pervading Nature, a major question is what are the origins of the ways humans manage to cooperate in sharing values and resources without automatically resorting to force? How do we manage sometimes to agree on the value of things and how do children learn to somehow compromise with others? That is the general question discussed in this chapter, in light of recent developmental research. Our goal is to review existing theoretical ideas and empirical evidence regarding the development that leads each individual child across a large variety of cultural and often highly contrasted demographic contexts to understand reciprocity in social exchanges. A second goal will be to understand how children systematically end up building some principled notions of equivalence and shared values with others, fostering cooperation, and somehow transcending competition or any forms of coercion. In the first part of the chapter we discuss sharing in development. We review evidence on the primordial development of shared and reciprocated experience, documenting what would be the universal chronological development of three forms of intersubjectivity between birth and 24 months. This development leads the child toward the first expression of an ethical stance by the third year of life. In the second part of the chapter, we then turn toward the development of fairness proper, construed as equity norms that guide exchanges with peers and others. We view this development as co-emerging with self-consciousness, in particular with a new care for reputation and the onset of a propensity to construe oneself through the evaluative eyes of others (Rochat, 2009; 2014). Before concluding and providing a general summary of the main ideas, in a third part we consider the degree to which culture plays a role in the development of fairness in sharing with 13 SHARING AND FAIRNESS IN DEVELOPMENT
Future of Mobile Commerce: An Exploratory Study on Factors affecting Mobile Users’ Behaviour Intention

Mobile commerce (M-commerce) being the subset of e-commerce, signifies a new field of business opportunity. The future of mobile commerce depends on how the mobile users’ intend to adopt this new technology induced business model. With the success of e-commerce in India, there is a huge potential for m-commerce growth. As m-commerce technologies grow and mature, it is the users’ experience and adoption of m-commerce that will drive its growth. The users’ acceptance of m-commerce depends upon various factors, which influence his/her behaviour towards m-commerce. The current research is an effort to identify such antecedents that affects behavioural intention of mobile users towards m-commerce. A survey was conducted among 150 internet mobile users in Chandigarh city using structured self-administered questionnaire to identify such factors. The results show that perceived enjoyment and perceived usefulness are the most important factors followed by trust and perceived cost, which affects mobile users’ behaviour intention to use m-commerce. Perceived ease of use and social influence was not found to have significant influence on mobile users’ behaviour intention. The findings of this research show strong empirical base for all marketers and strategists who are looking to take full advantage of the strength of m-commerce.
Deviated Expectation based Classification Method for Stock Price Prediction

Nowadays, with the fast development of social media, the instant financial news can be quickly spread over the Internet and consequently results in the strong vibration of s tock market within a short period of time. To capture the effect of financial news, various classification algorithms are proposed in financial data mining domain. Unfortunately, it has been shown that the positive news might not necessarily drive up the stock price. It is believed that there must exist some underlying events, called anchor events in this paper, which drive the stock market up or down. Therefore, this paper proposed the classification should be performed not only based on the textual features of financial news, but also the semantic distance between the testing set of news and the set of news of anchor events. Accordingly, such semantic distance is measured as deviated expectation calculated based on the distance between two set of extracted topics. The proposed method involves two steps, i.e., calculating whether the testing news is consistent with anchor events or not, and calculating how far the testing news is from the anchor ev ents. We then evaluate our method as well as the state-of-the-art classification algorithms on some real data sets. The promising experimental results have demonstrated that the proposed method is superior to the state-of-the-art classification algorithms in terms of classification accuracy.
THE NEUROPSYCHOLOGY OF PATIENTS WITH CLINICALLY DIAGNOSED IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS

OBJECTIVETo compare the neuropsychological performance of patients with idiopathic normal pressure hydrocephalus (INPH) with that of healthy individuals and to examine its relation to neurological signs, vascular comorbidity, and background factors. METHODSA consecutive series of 58 patients with INPH underwent neurological, neuroradiological, and neuropsychological examinations. The neuropsychological tests, measuring vigilance, fine movements of the hands, learning, working memory, and aspects of executive functioning, were also administered to 108 healthy individuals. RESULTSPatients performed worse than healthy individuals on all included tests. Significant correlations between test results were more frequent and stronger among patients and the degree of neuropsychological impairment was related to the severity of other signs of INPH. Patients with vascular risk factors performed worse than those without. CONCLUSIONThe neuropsychological deficits in INPH are widely distributed, interrelated, associated with neurological signs, and aggravated by vascular comorbidity.
Self-esteem and the occupational stress process: testing two alternative models in a sample of blue-collar workers.

Blue-collar workers (4,523 men and 927 women) participated in a survey comparing two alternative models, one assuming the level of self-esteem (SE) to result to a significant extent from the strain induced by occupational stressors and the other stating the level of SE as a determinant of stressor perception and experienced strain. The results of multiple regression analyses did not support the latter model, whereas the first model was partially supported: Monotony was associated with increased strain and decreased SE among younger (< or = 35 years) male participants and older (> 35 years) female participants, and lack of control related to increased strain and decreased SE among older male participants. These observations were made in the context of psychological strain symptoms but not in the context of physiological strain symptoms.