Miracle-dz/UniFAR-FTUs huggingface dataset:
Immuno-histochemical study of the expression of Bcl-2 in the Leydig's interstitial cells and primary spermatocyte cells of adult male rabbit under the effect of oral Gossypol intake

Gossypol is a natural compound extracted from the seeds of some species of cotton plants (Gossypium species). Gossypol displays various drug properties, including male antifertility, antiproliferative activity on tumor cells (leukemia, prostate, adrenal, etc.) and endometriosis. Recently, the action of gossypol has been thought to induce apoptosis in the target cells especially male testicular tissue. The current study was planned to evaluate the effect of oral intake of gossypol on the expression of anti-apoptotic Bcl-2 gene in the interstitial cells of Leydig and primary spermatocyte cells of adult rabbit. Thirty adult male rabbits were used, subdivided into 5 equal groups. Group1 represented control group, groups 2, 3, and 4 represented rabbits intubated with 1.05mg/day gossypol suspended in 1ml. olive oil for 3,6 and 9 weeks respectively. Group5 rabbits were subjected to gossypol oral intake in the same manner for 9weeks and were left for another 9weeks as recovery periods. All rabbits were sacrificed after 24hrs from last dose except group5 rabbits, testes were extracted fixed in neutral buffered formol and histologically processed for 5um paraffin sections. Detection of Bcl-2 protein was done by using labeled streptavidin biotin technique with the monoclonal Bcl-2 antibody. The evaluation of Bcl-2 expression in the interstitial cells of Leydig and primary spermatocyte cells, as an optical density, were done by the aid of image analysis system. The obtained data were statistically analyzed by using student t-test. The study showed that there was a positive Bcl-2 expression in the interstitial cells of Leydig in all study groups, and there were statistically significant increase in the Bcl-2 expression in groups 2, 3 and 4 in comparison to control rabbits values (p<0.001). The recovery group rabbits showed a statistically significant decrease in the Bcl-2 expression (p<0.001) in comparison to control rabbits values. The primary spermatocyte cells showed a very weak Bcl-2 expression in control group rabbits and rabbits of groups 2 and 3. After 9weeks gossypol administration there was a positive Bcl-2 expression in some primary spermatocyte cells (p<0.001) and the overexpression of Bcl-2 was continued in the recovery group rabbits (p<0.001). The study concluded that gossypol may trigger Bcl-2 expression in interstitial cells of Leydig, which started after 2weeks of oral administration and this effect is diminished after cessation of oral intake. Also there was an increase in Bcl-2 protein expression in primary spermatocyte cells after 9weeks of oral gossypol intake and that increase persisted even after cessation of gossypol. The study recommends further study about the role of gossypol on the relation between apoptosis inducing gene and apoptosis inhibiting gene in the testicular tissues.
Visual plasticity and exercise revisited: no evidence for a “cycling lane”

Experiments using enriched environments have shown that physical exercise modulates visual plasticity in rodents. A recent study (Lunghi & Sale, 2015, doi: 10.1016/j.cub.2015.10.026) investigated whether exercise also affects visual plasticity in adult humans. The plastic effect they measured was the shift in ocular dominance caused by 2 hours of monocular deprivation (e.g. by an eye patch). They used a binocular rivalry task to measure this shift. They found that the magnitude of the shift was increased by exercise during the deprivation period. This effect of exercise was later disputed by a study that used a different behavioural task (Zhou et al., 2017, doi: 10.1155/2017/4780876). Our goal was to determine whether the difference in task was responsible for that study’s failure to find an exercise effect. We set out to replicate Lunghi & Sale (2015). We measured ocular dominance with a rivalry task before and after 2 hours of deprivation. We measured data from two conditions in 30 subjects. On two separate days they either performed exercise or rested during the deprivation period. Contrary to the previous study, we find no significant effect of exercise. We hypothesise that exercise may affect rivalry dynamics in a way that interacts with the measurement of the deprivation effect.
Hunting the hunters: Wildlife Monitoring System

During the last decades, there has been a dramatic rise in number of illegal animal poaching incidents. Wildlife Monitoring Systems (WMSs) are emerging as a solution to help reduce poaching incidents by monitoring the activities of wild animals. The technological advances in low-power wireless networks have paved the way to exploit their potential for utilizing in wireless based WMS. One of the fundamental difficulties for utilizing existing wireless based WMS is the lack of full network connectivity provision due to the sparsely con-specific mobility behaviour of wild animals. Unlike static network applications, where the proximity among sensor nodes is fixed, wild animals often show signs of movement which alters the spatial proximity between neighbouring sensor nodes. To address this challenge, this thesis deals with leveraging short-rage radio and lowpower wide area networks to provide a communication network architecture that is energy-efficient, reliable, and has a low latency. We present a single-hop, multi-hop, and opportunistic multi-hop hybrid tree network architecture for WMS. Moreover, in wildlife monitoring applications, WMS often has to deal with frequent herd mobility. We address this issue by applying a herd-movement adaptive scheme. The particular focus of this technique is to have a strategy to adapt to the movement pattern of animals to make the communication network more efficient. We developed a mobility state driven data advertising control scheme based on an unsupervised learning algorithm. In addition, we implement a managed data dissemination scheme with controlling and prioritizing data replication function. In contrast to existing forwarding algorithms, it optimally makes data forwarding decisions by utilizing locally accessible information. Hence, the proposed algorithm adapts to dynamic network topology caused by the inherent sporadic connectivity among mobile herd of animals. Finally, the application of WMS communication network is demonstrated for inferring movement of an animal from the received signal information. This is introduced by using short-range radio for proximity and relative ranging as an alternative approach for the current use of GPS to examine the mobility interaction between wild animals. The developed animal movement analysis framework helps to infer how animal population density changes due to certain natural disturbances and how the animals interact to one another.
A Comparison of Symmetrical and Asymmetrical Triazine Herbicides for Enhanced Degradation in Three Midwestern Soils

Abstract The triazines are one of the most widely used herbicide classes ever developed and are critical for managing weed populations that have developed herbicide resistance. These herbicides are traditionally valued for their residual weed control in more than 50 crops. Scientific literature suggests that atrazine, and perhaps other s-triazines, may no longer remain persistent in soils due to enhanced microbial degradation. Experiments examined the rate of degradation of atrazine and two other triazine herbicides, simazine and metribuzin, in both atrazine-adapted and non-history Corn Belt soils, with similar soils being used from each state as a comparison of potential triazine degradation. In three soils with no history of atrazine use, the t1/2 of atrazine was at least four times greater than in three soils with a history of atrazine use. Simazine degradation in the same three sets of soils was 2.4 to 15 times more rapid in history soils than non-history soils. Metribuzin in history soils degraded at 0.6, 0.9, and 1.9 times the rate seen in the same three non-history soils. These results indicate enhanced degradation of the symmetrical triazine simazine, but not of the asymmetrical triazine metribuzin.
Phenotypic Heterogeneity of Rat Arterial Smooth Muscle Cell Clones

Abstract It is well accepted that smooth muscle cells (SMCs) cultured from normal rat arterial media have different morphological and biological features compared with SMCs cultured from experimental intimal thickening (IT) 15 days after endothelial injury. It is not known, however, whether the phenotypic modulation producing IT cells occurs in any medial SMCs or only in a particular SMC subpopulation. To distinguish among these possibilities, the phenotypic features of SMC clones derived from normal adult media and the IT 15 days after endothelial lesion were analyzed according to morphological appearance, replicative activity in the presence and absence of fetal calf serum, and [3H]thymidine incorporation and motile activity; these features were compared with those of the respective SMC parental populations. Two categories of SMC clones predominated: spindle clones, with morphological features similar to those of the parental population from the normal media, and epithelioid clones, with morphological f.
The role of system quality and content quality in explaining e-learning continuance intention: An Evidence from Malaysian e-learning users

System quality and content quality has long been adopted to study e-learning acceptance. However, it’s role in explaining confirmation stage (continuance intention) is still in vague. The current study combines systems quality and content quality in a theoretical framework to examine it’s impact on users continuance intention. The research model and hypotheses was tested using 427 Malaysian e-learning users via SPSS. Results indicate that both predictors were significantly related to e-learning continuance intention. The findings from this study provide useful insights for further research
STUDIES OF EFFICIENCY OF THE COMPOSITE SYSTEM "LYMPHOSILICA" IN MODELING EXPERIMENTAL OBESITY IN RATS

mass transfer zones in the absorption sites increased drugs bioavailability. creation of such the pharmacological burden on a body increasing the bioactivity and bioavailability of biodegradable polymers biopolymers The features of the influence of the nanocomposite system (Lymphosilica supplement), which was created on the basis of hydroconsolidated finely divided silica and plant materials with a high content of polyphenols, flavonoids, terpenes, polysaccharides on liver cytophysiological characteristics under the conditions of the development of metabolic syndrome and hepatotoxicity under simulated alimentary, were studied.Biochemical studies of blood serum and histological analysis of liver tissue were performed. It was shown that a high-calorie diet of rats over 100 days leads to the development of individual manifestations of obesity and metabolic syndrome, which are expressed in an increase in body weight and visceral fat, the development of the initial and middle stages of parenchymal fatty liver dystrophy with a decrease in morphological manifestations of the synthetic activity of the nucleus, with slight deviations at the biochemical level.The introduction of a phytocomposite does not lead to pathological changes in the organism of rats, but in some cases leads to manifestations of “adaptive stress” of liver hepatocytes, both with a standard diet and with a high-calorie diet. The positive effect of the composite system on reducing the proportion of visceral fat (by 38%) in rats with a standard diet was shown, and against the background of simulated alimentary obesity, normalization of the level of bilirubin (25 % decrease compared with alimentary obesity) and its fractions, lower levels cholesterol and alkaline phosphatase (in both cases by 19% compared with initial obesity), increased globulin fractions of blood serum, protective effect against dystrophic changes in liver tissue.
An overview on Chronic Kidney Disease allied risk factors and complications

Chronic kidney disease is a long term condition characterised by the gradual loss of kidney function at least a period of 3 months or more. About two-third of the cases are mainly caused due to HTN and DM. The symptom load plays a crucial role in the patient's disease experience and among the main signs of CKD are troubling physical and psychological symptoms. The evaluation of the symptom burden of CKD patients is of the utmost importance in clinical management. The risk factors include age, sex, race and ethnicity, family history, drug use, smoking, and socioeconomic status; and other comorbidities, such as hypertension and diabetes. Some risk factors can be modified and prevent or slow down the progression to ESRD. CKD progression is associated with serious complications such as cardiovascular risk, dyslipidemia, anemia, nutritional issues, and mineral and bone disorders.
Phytochemical Screening and Evaluation of Antioxidant Power of Hydro-Ethanolic and Aqueous Leaves Extracts of Annona Muricata Linn (Soursop)

RESUME Introduction. Annona muricata L. est une plante de la famille des annonacees largement utilisee par les populations de nombreux pays du monde, notamment celles du Cameroun. A la fois cultivee et sauvage, cette plante est presentee comme possedant certaines proprietes medicinales. Le but de cette etude etait d’evaluer la composition phytochimique et le pouvoir antioxydant des extraits hydro-ethanoliques et aqueux des feuilles de Annona muricata L. Methodes.La composition phytochimique des extraits a ete realisee a l'aide de reactions colorimetriques, tandis que la teneur en phenols totaux a ete determinee par la methode de Folin-Ciocalteu. Le pouvoir antioxydant des extrais a ete evaluee par des methodes complementaires (DPPH et RAP). Resultats: la composition phytochimique a revele la presence de composes phenoliques, de glycosides cardiaques et de sucres dans les deux extraits, tandis que les alcaloides etaient presents uniquement dans l'extrait hydroethanolique. La teneur en phenols totaux de l'extrait hydro-ethanolique etait significativement superieure a celle de l'extrait aqueux (p <0,05). Les resultats du test DPPH et ceux du test RAP ont egalement montre que l'extrait hydro-ethanolique avait un pouvoir antioxydant superieur a celui de l'extrait aqueux. (p <0,05). Conclusion: ces resultats suggerent que les feuilles de Annona muricata L. representent une source potentielle de composes antioxydants bien que leur nature et leur nombre varient d'un extrait a l'autre. ABSTRACT Background. Annona muricata L. is a plant of the Annonaceae family widely used by people in many countries of the world, especially those of Cameroon. Both cultivated and wild, this plant is presented as having some medicinal properties. The aim of this study was to evaluate phytochemical composition and antioxydant power of hydro-ethanolic and aqueous leaves extracts of Annona muricata L. Methods. Phytochemical composition of the extracts was performed using colorimetric reactions while total phenols content was determined by the Folin-Ciocalteu method. Extracts antioxidant power was evaluated by complementary methods (DPPH and RAP). Results. phytochemical composition revealed the presence of phenolics compounds, cardiac glycosides and sugars in both extracts, while alkaloids were present only in hydro-ethanolic extract. Total phenols content of hydro-ethanolic extract was significantly higher than that of aqueous extract (p <0.05). The results of DPPH test and those of RAP test also showed that hydro-ethanolic extract had a greater antioxidant power than aqueous extract. (p <0.05). Conclusion. These results suggest that Annona muricata L. represent a potential source of antioxidant compounds although these compounds vary in kind and number from one extract to another.
Developing prognostic gene panel of survival time in lung adenocarcinoma patients using machine learning

Background Transcriptome data generates massive amounts of information that can be used for characterization and prognosis of patient outcomes for many diseases. The goal of our research is to predict the survival time of lung adenocarcinoma patients and improve the accuracy of classifying the long-survival cohort and short-survival cohort. Methods We filtered prognostic features related with survival time of lung adenocarcinoma patients by the method of Relief and predicted whether survival time of the patient is >3 years or not—using eight machine learning algorithms (Support Vector Machines, Random Forests, Logistic Regression, Naïve Bayes, Linear Regression, Support Vector Regression (kernel Poly), Support Vector Regression (kernel Linear), and Ridge Regression). Then the best-performed algorithm was chosen to build a predictive model of survival time of lung adenocarcinoma patients. Further, another dataset was used to verify the stability and suitability of this model. We explored the underlying mechanisms of RNA expression changes with the corresponding DNA mutations and DNA methylation patterns in the 22 selected genetic features. Results The best machine learning algorithm was Naïve Bayes (accuracy=75%, AUC =0.81) using the top 22 genetic features, and this algorithm had the stable and great performance on another dataset as well. The coupled mutation number of the long-survival group (>6 years) was less than the short-survival group (<1 year) in 22 genes (P=0.031). Conclusions The expression of gene panel can predict the survival time of lung adenocarcinoma patients using Naïve Bayes. These 22 genes do affect the survival time of lung adenocarcinoma.
The Valley of the Dry Bones

This article explores Jewish contributions to, and influence on, the country music and bluegrass genres, arguing that there have been four key phases of Jewish-country interaction and that in recent years country and bluegrass Jews have taken a largely religious and liturgical turn as singer-songwriters in these genres. The first sections of this article identify several important stages of interaction, beginning with a phase between the 1940s and 1960s when Jews challenged antisemitism and sought assimilation and acceptance, a period in the 1970s when iconoclasts such as Kinky Friedman and Shel Silverstein came to the fore and substantially reshaped country music, and a phase from the 1980s to early 2000s when an instrumental-focused klezmer-bluegrass fusionism was central to constructing a Jewish-country identity. A longer, final section explores the more recent, religiously-themed country and bluegrass of performers such as Mare Winningham, Nefesh Mountain, and Joe Buchanan, and argues that Jewish country and bluegrass has taken an important liturgical turn.
PREDISPOSING, ENABLING, AND REINFORCING FACTORS THAT INFLUENCE FULL BASIC IMMUNIZATION COVERAGE IN BANGKALAN DISTRICT, MADURA ISLAND IN 2017

The cases of morbidity and mortality of babies and toddlers are continue to occur because of negligence of the mothers in providing complete basic immunization to their babies. This study is a cross-sectional study that was conducted to identify the predisposing, enabling, and reinforcing factors that influence full basic immunization coverage. The study was performed on mothers who had 9-12 months old child spread in 22 villages, purposively selected through from 22 community health centers in Bangkalan District, Madura Island. 200 mothers were selected as the study's respondents. The data were collected through questionnaires and from the book of "Kesehatan Ibu dan Anak" (KIA). The result of the study was obtained using logistic regression statistical test and it showed that the factors that influenced of full basic immunization coverage in Bangkalan District, Madura Island, were family income as predisposing factor (OR=2.26; 95% CI= 1.14 to 4.51; p= 0.020); health facility as enabling factor (OR=3.03; 95% CI= 1.59 to 5.80; p= 0.001); and community leader support as reinforcing factor (OR=2.56; 95% CI= 1.33 to 4.92; p= 0.005).
A study on the ineffectiveness of Japan’s Stewardship Code (2014) confronted with Japan’s Fair Disclosure Rule (2018)

Background: Abenomics is a policy mix that was designed and introduced by the Liberal Dem­ocratic Party (LDP) in Japan. It aims to revive the Japanese economy and has been advocated by Prime Minister Shinzo Abe and his Cabinet since December 2012. Since 1989, Japan has experienced a severe financial crisis and almost 30 years of economic stagnation, known as the “Lost Decades”. Research purpose: This study examines the ineffectiveness of one of Abenomics’ solutions, Japan’s Stewardship Code (2014), “the Code,” confronted with Japan’s Fair Disclosure Rule (2018). The Code aims to both enhance returns for financial investors and foster the corporate value and sus­tainable growth of investee companies. The purpose of this study is, first, to clarify the relationship between stock prices and earnings-to-price ratios in the Japanese stock market, reflecting the worst performance period of 1989–2018, when stock prices continuously declined. The second is to judge whether it is meaningful or meaningless to carry out the Code from a long-term investors’ perspective. Methods: I used an approach by Brealey, Myers, and Allen (2008), where a discount dividend model and the net present value of future-growth opportunities are discussed. Conclusions: I concluded that it would surely be ineffective to carry out the Code in Japan.
A CONCEPT ON IMPLEMENTATION OF SMART CITY

As higher number of population is living in metro cities, hence it’s important to make the cities smarter for their movement and accommodation. Smart refers to the intellectual use of technology to improve the productivity of a city’s essential infrastructure. Smart City removes the inferior complexity of our daily lives and improve the standard of life of inhabitants in these cities. Smart City is moreover considered as a measure of intelligence in urban areas. We put the features of a city that are pre-requisite to be considered as a smart city. This paper focus is on the challenge to minimize language barriers for any tourist or inhabitant of a smart city. Any person new to a smart city must be able to easily mobilize around the city with the help of advanced technologies. We try to take advantage of already established technologies to implement in a more strategic, centralized and integrated manner to benefit locals, tourists, governments, businesses, etc. The device that is present with us most of the time is smart phone and there is a valuable network among mobile services by the central and local government. Therefore, the services provided via smart phones like apps will help the citizens to make the best use of services provided in a smart city.
CNN-LSTM Model for Verifying Predictions of Covid-19 Cases

COVID-19 disease came to earth in December 2019 in Wuhan. It is increasing exponentially throughout the world and affected an enormous number of human beings. The World Health Organization (WHO) on March 11, 2020 declared COVID-19 was characterized as “Pandemic”. Clinical Doctors have been working on it 24 hours in the entire world. These doctors are testing whether the particular human has been affected with the disease using testing kit and other related process. Researchers have been working day-night for developing vaccine for the disease. Since the rate of affected people is so high, it is difficult for clinical doctors to check such a large number of coronavirus detected humans within reasonable time. This paper attempts to use Machine Learning Approach to build up model which will help clinical doctors for verification of disease within short period of time and also the paper attempts to predict growth of the disease in near future in the world. Two models were used for achieving this purpose- One is based on Convolutional Neural Network model where as another one consists of Convolutional Neural Network and Recurrent Neural Network. These two models are evaluated and compared for verifying the predicted result with respect to the original one. Experimental results indicate that the combined CNN-LSTM approach outperforms well over the other model.