Miracle-dz/UniFAR-FTUs huggingface dataset:
Real-life Diagnostic and Therapeutic Approach to CLL: A New Proposal from an Expert Panel in Tuscany Region

BACKGROUND: In the last years genomic and somatic alterations have shown to play a pivotal role in the pathogenesis of chronic lymphocytic leukemia (CLL) and new prognostic factors have been identified accordingly.AIM: To describe a real-life diagnostic and therapeutic approach to CLL that takes into account the role of genomic and somatic prognostic factors in the risk stratification of developing progressive disease, and treatment decision.METHODS: This new proposal has been developed and validated by ten key opinion leaders from Tuscany Region during two Expert Meetings. The approach suggested comes from their experience in daily clinical practice and is supported by guidelines recommendations, clinical trials results, and drugs prescribing conditions in Italy.RESULTS: Beside TP53 deletion or mutated status, the Expert Panel highlighted the importance of the IGHV mutation status characterization, since the diagnosis, in order to identify patients who will have a more aggressive progression. Furthermore, just before starting treatment, to obtain useful prognostic information and indication in the selection of the therapy, they recommend cytogenetic analysis for the detection of del(11q), trisomy 12, del(13q), del(17p), conventional karyotyping of stimulated CLL cells, TP53 sequencing, and molecular genetic analysis to detect IGHV mutation status.CONCLUSIONS: The Expert Panel recognized the limitations associated with traditional staging systems in identifying patients who will have a more aggressive disease course and predicting response to treatment and suggested a real-life diagnostic and therapeutic approach to CLL to update the current patient management in light of recent advances that have improved understanding of CLL.
Behavior of Physicochemical Parameters
and Potentially Toxic Metals in Surface Water
Evaluated by Means of Multimetric Indices:
a Case Study in a Protected Natural
Area of Peru

The behavior of physical-chemical parameters and potentially toxic metals in the surface water of Lake Chinchaycocha was evaluated using multimetric indices between March and December 2018. Water samples were collected from 10 sampling sites during the rainy and low-water periods, and water quality was determined using the WQI CCME and the Shannon-Wiener index, followed by multivariate analysis. The WQI CCME rated good quality water, except for the LCh1 site. The Shannon-Wiener index rated moderate and extremely contaminated water. The cluster analysis grouped the sampling sites into two clusters with similar characteristics. The ACP presented a total percentage variation of 76.07%. Therefore, this study provides an updated state of the water quality of Lake Chinchaycocha using different indices and multivariate techniques.
Low‐Cost, Scalable, and Reusable Photothermal Layers for Highly Efficient Solar Steam Generation and Versatile Energy Conversion

Solar steam generation (SSG) based on the photothermal effect has been considered to be a promising avenue for freshwater production. However, the fabrication of highly‐efficient photothermal layers, at large‐scale and low‐cost is still a challenge, hindering practical applications. Herein, it is demonstrated that carbonized towel‐gourd sponges (CTGS) are excellent photothermal materials. And a capillarity‐driven interfacial self‐coating method is developed to prepare the super‐hydrophilic CTGS/paper photothermal layer. The SSG device based on the CTGS/paper exhibits a high evaporation rate of 1.53 kg m−2 h−1 with an efficiency of 95.9% under 1 sun irradiation. The high evaporation rate only slightly reduces when confronting the diverse and complex practical SSG conditions, such as seawater and waste water. Moreover, CTGS/paper has the advantages of simple preparation, recyclablability, low‐cost (≈4 $ per m2), high‐efficiency, flexibility, and scalability, which are the important prerequisites for promoting SSG techniques for industrialization and practical applications. In addition, the versatile energy conversion ability of the CTGS/paper is also demonstrated. Assisted by the photothermal effect of CTGS/paper, solar energy is converted to mechanical energy and electricity.
Efficacy of different vaccination programs of live 4/91 strain against Thai QX-like infectious bronchitis virus in broiler chickens

Thai QX-like infectious bronchitis virus (IBV) has caused problems in commercial chicken farms as well as small farms in many parts of Thailand. This study investigated the level of protection generated by vaccination with different IBV vaccination programs, 4/91 strain against Thai QX-like IBV. One hundred 1 day old female broiler chickens were randomly divided into 5 groups of 20 chickens each. The chickens in Group 1 were vaccinated with Ma5 strain IBV vaccine at 1 day old and with 4/91 strain IBV vaccine at 14 days old. The chickens in Group 2 were vaccinated with Ma5 and simultaneously with 4/91 strain IBV vaccine at 1 day old. The chickens in Group 3 were vaccinated with a combined Newcastle disease virus, C2 strain and IBV, B48 strain vaccine at 1 day old and with 4/91 strain IBV vaccine at 14 days old. The chickens in Groups 4 and 5 did not receive IBV vaccine and served as positive and negative control groups, respectively. At 28 days of age, the chickens in Groups 1-4 were individually challenged with 104.2 EID50 of Thai QX-like IBV (isolate THA80151). Protection was evaluated at 7 days post-inoculation (DPI). Results revealed that the clinical sign and histopathological lesion score of the tracheas of the vaccinated chickens were significantly (p<0.05) lower than those of the non-vaccinated, challenged control chickens. These results indicate that improvement in protection was achieved against the challenge with Thai QX-like IBV by the vaccination programs used in this study. However, complete protection was not observed.
CAN THE EPIC FOOD FREQUENCY QUESTIONNAIRE BE APPLIED TO THE POPULATION IN ROMANIA

Aim: The application of the EPIC food frequency questionnaire to the population of Romania in order to obtain information about nutritional intake/dietary pattern. Material and Methods: EPIC Norfolk questionnaire (translated and adapted) was administered by an interviewer to 125 people, who also completed the 24-hour diet recall on two different days. In addition, data was collected in regards to anthropometry (weight, height, body mass index), as well as information related to other lifestyle factors, such as rural / urban, education, physical activity or income. Calculating the nutrients was done on the basis of tables published by the Ministry of Health. For statistical data processing the SPPS 17.0 software was used. Results: The current rating refers to data obtained by analyzing the questionnaires for the 24-hour diet recall. The analysis of the kinds of food supported the correspondence with the original English questionnaire. By analyzing the energy and macronutrient intake through the both methods, depending on the area of ​​origin, it appears that rural people consume a higher percentage of saturated fat (p = 0.006) and lower of insoluble fiber (p = 0.042) and carbohydrates (p = 0.036) compared to those in urban areas, which are statistically significant differences. On average, the intake of kcal/day was 1741.22, carbohydrates/day 201.66 g, respectively 56.13%, protein 88.33 g/day respectively 25.46%, fibers 17.25 g/day, fat 94.67 g/day respectively 18.28%, of which saturated fat 22 g/day (11.04%), monounsaturated 24.65 g/day (12.24%), polyunsaturated 10.48 g/day (5.3%); cholesterol 329.63 mg/day. Conclusions: The analysis in this phase of the study was necessary to equate the foods from the food frequency questionnaire EPIC with those consumed by the population of Romania expressed in the 24-hour diet recall and also to have a basis for comparison with food frequency questionnaires applied now and in 6-9 months in order to validate it.
EBE VE HEMŞİRELERDE ÇALIŞMA KOŞULLARININ OBSESİF KOMPULSİF BOZUKLUK VE ANKSİYETE ÜZERİNE ETKİSİNİN BELİRLENMESİ

Amac: Bu calisma ebe ve hemsirelerin calisma yasamina iliskin bazi ozelliklerinin obsesif-kompulsif belirti ve anksiyete duzeyi uzerinde etkisinin belirlenmesi amaciyla yapilmistir. Gerec ve Yontemler: Bu tanimlayici tipte bir arastirmadir. Arastirmanin evrenini, Tunceli Devlet Hastanesi, Tunceli Dis Hastanesi ve Tunceli Il Merkezinde faaliyet gosteren 3 Aile Sagligi Merkezinde calisan 157 ebe ve hemsire olusturmustur. Arastirmanin verileri Kisisel Bilgi Formu, Maudsley Obsesif Kompulsif Soru Listesi (MOKSL) ve Beck Anksiyete Olcegi (BAO) ile toplanmistir. Verilerin istatistiksel degerlendirmesinde tanimlayici istatistikler, Mann-Whitney U testi, Kruskal-Wallis testi ve Spearman Korelasyon analizi kullanilmistir. Bulgular: Calismaya katilan ebe ve hemsirelerin MOKSL puan ortalamasi 29,34±6,01; BAO puan ortalamalari 8,20±8,64’tur. MOKSL ve BAO puanlari ile sosyodemografik veriler karsilastirildiginda cinsiyet degiskeninde fark oldugu belirlendi. Ailede ve calisma arkadaslari icinde takintili dusunceye sahip bireylerin olmasi ve calisma pozisyonuna gore MOKSL ve BAO puanlari arasinda anlamli fark oldugu; meslege gore MOKSL puanlari arasinda ve haftalik calisma saatine gore BAO puanlari arasinda anlamli fark oldugu (p<0,05) belirlenmistir. Meslegin kendisine uygunluguna gore olcek puanlari arasinda anlamli fark bulunmamistir. MOKSL ve BAO puanlari arasinda orta duzeyde ve negatif yonde iliski oldugu bulunmustur. Sonuc: Calismanin sonuclari, ebe ve hemsirelerin obsesif kompulsif belirtilerinin yuksek, anksiyetelerinin hafif duzeyde oldugunu ve bu belirtilerin meslek, calisma pozisyonu, haftalik calisma saati gibi degiskenlerden etkilendigini gostermektedir.
Fungal pathogens occurring on Orthopterida in Thailand

Two new fungal genera and six species occurring on insects in the orders Orthoptera and Phasmatodea (superorder Orthopterida) were discovered that are distributed across three families in the Hypocreales. Sixty-seven sequences generated in this study were used in a multi-locus phylogenetic study comprising SSU, LSU, TEF, RPB1 and RPB2 together with the nuclear intergenic region (IGR). These new taxa are introduced as Metarhizium gryllidicola, M. phasmatodeae, Neotorrubiella chinghridicola, Ophiocordyceps kobayasii, O. krachonicola and Petchia siamensis. Petchia siamensis shows resemblance to Cordyceps mantidicola by infecting egg cases (ootheca) of praying mantis (Mantidae) and having obovoid perithecial heads but differs in the size of its perithecia and ascospore shape. Two new species in the Metarhizium cluster belonging to the M. anisopliae complex are described that differ from known species with respect to phialide size, conidia and host. Neotorrubiella chinghridicola resembles Torrubiella in the absence of a stipe and can be distinguished by the production of whole ascospores, which are not commonly found in Torrubiella (except in Torrubiella hemipterigena, which produces multiseptate, whole ascospores). Ophiocordyceps krachonicola is pathogenic to mole crickets and shows resemblance to O. nigrella, O. ravenelii and O. barnesii in having darkly pigmented stromata. Ophiocordyceps kobayasii occurs on small crickets, and is the phylogenetic sister species of taxa in the ‘sphecocephala’ clade.
Comparison of biogas production obtained from samples of Mitú and Sibundoy municipal solid waste

This study compares the calorific power of biogas obtained from the municipal solid waste (MSW)of two towns in Colombia,whose populations are affected by deficiencies in the supply of electricity. The production of biogas would represent an importantopportunity to meet these needs, taking advantage of the solid waste generated, in whose composition organic material predominates(45 %). For this purpose, MSW samples were taken from the municipalities of Mitú (Vaupés) and Sibundoy (Putumayo), in orderto establish their relevance to produce biogas. For each sample, the organic waste was characterized in terms of its macroscopiccomposition, moisture content, ash, volatile and total solids. Subsequently, the composition of biogas obtained was determinedfrom anaerobic digestion tests with biological sludge as inoculum in different proportions and the calorific value of the gas wascalculated. It was found that organic waste from both municipalities is suitable to produce biogas due to the physicochemicalcharacteristics of the samples, the high methane content generated and, therefore, the satisfactory calorific power for its use in theproduction of electrical energy.
Iban Sebuyau Youth Slang: Radial Network Category Framework Analysis/ Slanga Remaja Iban Sebuyau: Analisis Kerangka Kategori Jaringan Radial

Slang is a free-grammatical rule of language phenomenon that exhibits the invention of vocabulary in a community groups in order to strengthen social identity. Overall, there are 15 data of Iban Sebuyau teenagers slang which has been acquired and separated into noun categories (eight data) and verbs (seven data). This study will analyze seven types of words of Iban Sebuyau teenagers’ slang in Sarawak via the verb category. Besides, the slang of Iban Sebuyau teenagers’ data will be examined based on the Radial Network Category Framework as suggested by Lakoff (1987). Accordingly, this study applied qualitative methods to obtain field sampling based on 10 teenagers in Sebuyau which has been selected based on their comprehension on the slang. As a result, the findings shows that there are in total of 7 data of Iban Sebuyau teenagers slang has been obtained in verb categories such as merueh, ngaga’ peta, ngangat nyawa, belagu, nunjuk langit, melabur, and fogging. Overall, the Radial Network Category Framework approach able to describe the extensive meaning of Iban Sebuyau teenagers slang.
Prevalence of HIV and Associated Risk Factors Among Adults in Negele Borena Hospital, Guji zone, Oromia Region, Ethiopia

Background:- The peak incidence of Human Immunodeficiency Virus (HIV) infection occurs among adults who are at the most productive age of the population. They are vulnerable to HIV because of their age, living arrangement, and cultural influences. Objective:- The aim of this study is to determine the prevalence of HIV infection and its risk factors among adults in Negele Borena Hospital. Method:- A cross-sectional study was conducted on 384 adults in Nagele Borena Hospital from April to September, 2017. Self-administered questionnaire was used to collect data on socio-demographic variables, knowledge of HIV/STIs and behavioral factors. In collaboration with the hospital work, whole blood samples were tested for the presence of antibody to HIV infection using National HIV rapid diagnostic tests algorithm. Chi-square test was conducted to identify risk factors, and finally, regression analysis was computed to identify the independent risk factors that influence the incidence of HIV/AIDS. Results:- The sero-prevalence of HIV was 11(2.86%) where 4(2.03%) and 7(3.74%) were males and females respectively. Alcohol drinking (AOR=5.2(1.1-25) and khat chewing (AOR=5.8, 95%CI 5.8 (1.3-27) discuss about sexual issues openly with their family AOR=13, 95%CI 13(1.6-102), peer pressure AOR=22.9, 95%CI22.9 (3.9-131) and multiple sexual partner (AOR=5.2, 95%CI 5.2(0.9-29) were the risk factors for HIV infection and HIV/AIDS transmission determinants. Conclusion and recommendation:- The prevalence of HIV infection among adults of Negele Borena Hospital is high. New infection among young people suggested that the disease is not under control yet in the country. Therefore, planning strategy to prevent the spread of HIV infection in town is critical. Keywords: Behavior, HIV/AIDS, prevalence, risk factor, transmission DOI : 10.7176/JHMN/68-03 Publication date: November 30 th 2019
EARLY DIAGNOSIS OF NEONATAL SEPSIS WITH SPECIAL FOCUS ON LEUKERGY TEST – A FORGOTTEN TOOL

Anubhav Prakash1, Richa Richa2, Bhupendra Narain3 From 1Senior Resident, Department of Pediatrics, Sri Krishna Medical College Hospital, Muzaffarpur, 2Junior Resident, Department of Pathology, 3Associate Professor, Department of Pediatrics, Patna Medical College Hospital, Patna, Bihar, India Correspondence to: Dr. Bhupendra Narain, C/O Mr. Rama Shankar Singh, Flat No 201, Maheshwari Complex, Biscoumaun Colony, PO Gulzarbagh, PS Alamgunj, Patna 800 007, Bihar, India. E-mail: brnarain@gmail.com Received 11 November 2019 Initial Review 24 November 2019 Accepted 13 December 2019
Factors affecting success of trial of labour afterprevious one lower segment Caesarean section

Objective: The aim was to analyze the different factors associated with successful trial of labor after previous one lower segment cesarean delivery in our institution. Patients and methods: A Prospective case-series study was done at Al-Batool Maternity Teaching Hospital, Mosul on 476 women with previous one lower segment Caesarean delivery subjected to trial of labour between January 2009 and mid June 2009. Results: Successful trial of labour and vaginal delivery was reported in 82%. The factors that were found to be significantly associated with successful trial of labour are: parity of 2-4, history of previous vaginal delivery and particularly history of vaginal birth after Caesarean, fetal malpresentation as the indication of previous Caesarean, inter-pregnancy interval longer than 12 months, gestational age ≤ 40 weeks, cervical dilation ≥4 cm, cervical effacement ≥50%, station lower than –1 and intact membrane at time of admission, clear liquor and neonatal weight < 4000 grams. Conclusions: The factors present in woman's obstetric history and during her intrapartum course in the current pregnancy and birth weight that had significant differences in this study can be used as predictor of successful trial of labour and will help obstetrician to identify women who are more likely to attempt trial of labor and have a successful vaginal birth after previous one lower segment Caesarean delivery.
Young Adult E-Cigarette Exposure: Implications for Policy and Prevention

Objective. The purpose of this study is to examine factors associated with e-cigarette use among college students to better understand their behavior. Using Ajzen’s Reasoned Action Approach, this study sought to better understanding the influence of attitudes, social norms, and perceived behavioral controls (PBCs) on college students’ intention to try e-cigarettes (even one puff) in the next 30 days. Methodology. This study employed three phases for a mixed methods design that took place between December 2015 and April 2016. Phase 1 used Middlestadt’s salient belief elicitation procedure to capture responses through an open ended survey (n=58). Phase 2, a pilot sample (n=49), was employed to develop and validate a quantitative measure of the underlying RAA constructs, using responses from Phase 1. For Phase 3, a convenience samples (n=499) allowed for the assessment of the measurement models of both the underlying and global constructs of the RAA using exploratory factor analysis, confirmatory factor analysis, and structural equation modeling. All samples consisted of University of Arkansas students between the ages of 18 and 26 years of age. Results. Responses from Phase 1 were used to develop a 162 item measure of the underlying constructs that was reduced to 78 items during Phase 2. During Phase 3, the underlying constructs, attitude, injunctive norms, and PBC were found to significantly predict their respective global measure. Global constructs loaded onto the predicted four factors: intent, attitude, social norms and PBC, after removing six items. In the final path model, global constructs attitude (.27, p<.001) and injunctive norm (.58, p<.001) significantly predicted
A Novel 1 Bit Wide-Angle Beam Scanning Reconfigurable Transmitarray Antenna Using an Equivalent Magnetic Dipole Element

A novel 1 bit reconfigurable transmitarray antenna (RTA) using an equivalent magnetic dipole element for wide-angle beam scanning at Ku-band is presented. The RTA element consists of a rectangular patch and a side-shorted patch with an equivalent magnetic dipole radiation. A 1 bit phase difference is achieved by controlling two p-i-n diodes on the side-shorted patch based on the current reversal mechanism. The half-power beamwidth of the presented antenna element is 142° in E-plane, which is significantly larger than other conventional elements. A RTA prototype with $16\times16$ elements is designed, fabricated, and tested. The measured results show good beam scanning capabilities of the 1 bit RTA. The measured gain in the broadside direction is 21.4 dBi, and the scan gain loss is 3.6 dB for the 60° scanned beam in E-plane.
Service Quality and Patients' Satisfaction on Ayurvedic Health Services

Ayurveda is one of the oldest and famous natural health care systems mostly practicing in south Asian region. It is originated in India and has developed in different countries through religious and cultural background of the local society. The main purpose of this study is to examine the impact of the service quality on patient satisfaction in the government Ayurvedic medical institutions in Jaffna district. The study is carried out as a questionnaire survey and used purposive non random sampling method to collect data from 591 respondents. The five dimensional SERVQUAL model proposed by Parasuraman et al. (1985) was employed to measure the service quality dimensions related to the Ayurvedic hospitals. Descriptive statistics and regression analysis were mainly employed to analyze the data. The results show that the service quality of the Ayurvedic medical institutions contribute significantly to the patients satisfaction. However, the patients’ satisfaction is not significantly influenced by tangible dimension and other dimensions i.e. reliability, responsiveness, assurance and empathy statistically and significantly enhance the patients’ satisfactions. It is necessary to improve the overall service quality of the Ayurvedic medical institutions in order to enhance the patients satisfaction who trust and take medicine from the government Ayurvedic institutions.
Dielectric metalenses with off-axis and multi-focal spots based on converging Airy beams with different initial velocities or accelerations

In the context of light focusing, converging Airy beams play an essential role. The two Airy beams that are commonly used in the literature for autofocusing of the Airy beams are mirror-symmetric. In this paper, we consider the two converging Airy beams to have different values of accelerations or initial velocities, the subject that up to our knowledge has not been studied before. To explore the effect of applying Airy beams with different initial velocities or accelerations, we apply the required phase and amplitude of the two launched Airy beams to a one-dimensional arrangement of dielectric c-shaped metaatoms. Silicon c-shaped metaatoms give us the opportunity of having full control of the phase and amplitude of the incident 700 nm light. Simulation results demonstrate that convergence of the two Airy beams with various values of initial velocities or accelerations causes the focal spot to deviate from the optical axis. The extent to which the focal spot deviates from the main axis depends strongly on the initial parameters of the included Airy beams. The focal spot coordinates that are achieved from the simulation results are well agreed with the analytical calculations that we also provided. Using the inutile space between the two launched Airy beams as an independent hyperbolic metalens, gives us the opportunity of designing a multi-focal metadevice with different off-axis and on-axis focal spot arrangements.