Miracle-dz/UniFAR-FTUs huggingface dataset:
Pathological findings in sporadic inclusion body myositis and GNE myopathy.

OBJECTIVE The following study compared the pathological findings between sporadic inclusion body myositis (sIBM) and Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase myopathy (GNEM) patients. METHODS An enzyme histochemistry was used to compare the pathological characteristics between 11 patients with sIBM and 16 patients with GNEM. RESULTS There were four pathological differences observed: (1) A majority of the rimmed vacuoles found in the sIBM patients resembled cracks, whereas the GNEM patients (P=0.004) had round or oval vacuoles. (2) A majority of the rimmed vacuoles that were located in the periphery of the atrophic muscle fibers of the sIBM patients. The patients with GNEM had a majority of the rimmed vacuoles in the center of the atrophic muscle fibers (P=0.001). (3) The patients with sIBM had basophilic granules in the rimmed vacuoles, which appeared to be fine granules that were sand-like particles. The GNEM patients had coarse granules (P=0.018). (4) The proportion of mononuclear cells invasion of muscle fibers was larger in the sIBM patients than the GNEM patients (P=0.047). The GNEM patients were younger on average than the sIBM patients at the onset of symptoms (P<0.001) and at the diagnosis age (P<0.001). The electromyography (EMG) showed the presence of myogenic lesions in 10 patients with sIBM, both myogenic and neurogenic lesions in one patients with sIBM and myogenic lesions in 16 patients with GNEM. CONCLUSION There were significant differences in the morphologies of the rimmed vacuoles between sIBM patients and GNEM patients.
FIFTEEN-YEAR ENROLLMENT TRENDS RELATED TO THE THREE COMPONENTS OF COMPREHENSIVE AGRICULTURAL EDUCATION PROGRAMS

The purpose of this study was to identify the agricultural education enrollment trends in Iowa using 15 years of data collected from 1991 to 2005. It was found that agricultural education enrollment, Supervised Agricultural Experience (SAE) participation, and FFA membership have grown. Using annualized growth rates, agricultural education enrollment (4.06%) grew more rapidly than SAE participation (1.65%) and FFA membership (2.39%). Although growth was realized in all three components, the widening gap between students who only enroll in agricultural education and those who also choose to participate in SAE and FFA is a concern. Increased female participation, 31.96% in 2005, accounted for much of the overall growth in total enrollment. SAE growth was attributed to increased participation in agriscience and agribusiness. The findings have implications for the profession’s ability to put into practice experiential learning theory, the philosophical approach of agricultural education, local program development and management, and the future of agricultural education.
The Effects of a Circuit Training Program on Muscle Strength, Agility, Anaerobic Performance and Cardiovascular Endurance

This study aimed to examine the effects of a circuit training program on muscle strength, agility, anaerobic performance and cardiovascular endurance. The study involved 24 freshmen (age 18.87+0.68 yr.) male students of the Faculty of Sport Science, Burapha University. They sample study were randomly divided into two groups: Circuit Training group (CT; n=12) and a Control group (C; n=12). Baseline data on height, weight, muscle strength (hand grip dynamometer and leg strength dynamometer), agility (agility TTest), and anaerobic performance (Running-based Anaerobic Sprint Test) and cardiovascular endurance (20 m Endurance Shuttle Run Test) were collected. The circuit training program included one circuit of eight stations of 30/60 seconds of work/rest interval with two cycles in Week 1-4, and 60/90 seconds of work/rest interval with three cycles in Week 5-8, performed three times per week. Data were analyzed using paired t-tests and independent sample t-test. Statistically significance level was set at 0.05. The results show that after 8 weeks of a training program, muscle strength, agility, anaerobic capacity and cardiovascular endurance increased significantly in the CT Group (p < 0.05), while significant increase was not observed in the C Group (p < 0.05). The results of this study suggest that the circuit training program improved muscle strength, agility, anaerobic capacity and cardiovascular endurance of the study subjects. This program may be used as a guideline for selecting a set of exercise to improve physical fitness. Keywords—Cardiovascular endurance, circuit training, physical fitness, anaerobic performance.
Random amplified DNA polymorphism of Klebsiella pneumoniae isolates from Mansoura University Hospitals, Egypt

Klebsiella pneumoniae is one of the major causes of nosocomial infection. Understanding the route and dynamics of dissemination in the outbreaks of infections relies on using accurate typing methods. This is achieved through molecular typing using random amplified polymorphic DNA (RAPD) analysis technique in correlation to the infection source and antibiotic resistance. In this study, a total of 300 clinical isolates were collected from different clinical sources among Mansoura University Hospitals, Dakahlia governorate, Egypt. Ninety six isolates were identified as K. pneumoniae. The antimicrobial susceptibility test showed high resistance to the majority of tested antimicrobials, especially to β-lactams. K. pneumoniae isolates were categorized into 24 different antimicrobial susceptibility patterns (A1-A24). Furthermore, RAPD analysis was applied as a molecular typing method using two individual primers, AP3 and OPA13. RAPD typing showed 51 distinct patterns (R1-R51) verified into 5 groups (A, B, C, D, and E). The most common patterns were D11, D18 and D19 included in groups B and C. On the other hand, more molecular variable isolates were distributed in groups D and E. Correlation between RAPD analysis and antibiotying established that specific RAPD pattern D11 was associated with multidrug resistant isolates. This confirms that cross acquisition can play an important role in the epidemiology of nosocomial colonization and infection with K. pneumoniae at Mansoura University Hospitals. In conclusion, this study emphasized the need for appropriate monitoring of K. pneumoniae infections, by using both traditional and molecular methods. RAPD proved to be effective technique in discriminating K. pneumoniae isolates. Key words: Klebsiella pneumoniae, random amplified polymorphic DNA (RAPD), antimicrobial susceptibility, typing, dendrogram.
Integrating Interdisciplinary Thinking and Practice: a Case Study of a Victorian University in Australia

The value of interdisciplinary approaches to curriculum have been considered successful along multiple fronts; including reducing administrative burden from inter departmental collaboration, providing "intellectual" solutions to problems and breaking academic discipline boundaries. Criticism from industry often focuses on educators not preparing graduates for work in the real world. A major reason underpinning this criticism is that the students are not exposed to the requisite skills to make them work- ready. Despite the pressures to include interdisciplinary approaches from an ethical perspective, putting it into practice is difficult. This paper presents the findings of involving students from three different schools from a Victorian university in Australia: built environment, business and computer science. The project was developed as part of a state government competitive fund where industry, staff and students worked together to support each other and realize mutual benefits. The aim of the study was to develop an approach involving students in a theory-practice model of a real world project by selecting a building within the university as a case study to arm students with real world knowledge focusing on sustainability outcomes. The objective was to assist in preparing students from different disciplines for better workplace experiences, where they can bring in interdisciplinary thinking and practice into their day-day operations. The outcomes for the university, in using this building as a living laboratory, was to capture lessons learned through the process of improving future building developments from a sustainability perspective. Student involvement was successful, but true interdisciplinary engagement was not achieved.
Development Rights Transfer: An Exploratory Essay

Chicago's Old Stock Exchange Building, a 13-story architectural landmark of international stature, was demolished in 1972 to make way for a pedestrian 45-story office tower on one of the Chicago Loop's prime business locations. In Manhattan, the Tudor Parks, described by The New York Times as "two quiet green islands, suspended above the compacted chaos of East 42nd Street in the privately-owned Tudor City development,"' are targeted as the site of luxury high-rise buildings. Puerto Rico's Phosphorescent Bay, a unique ecological resource whose waters explode at dusk with the luminescence of billions of tiny dinoflagellates, is threatened with imminent degradation by industrial development on the still virgin lands that encircle the Bay. These and countless other imperiled resources seem to have little in common at first glance. Some are man-made, others nature's own. Their locations run from bustling downtown sites to once remote rain forests and nature preserves. They are cherished for purposes as diverse as landmark preservation, open space maintenance, and protection of the natural environment. Each is vulnerable, however, because it is a low density resource situated where the marketplace demands a high density use. This clash between resource protection and the development juggernaut defines the contours of a national land use dilemma. The recurring failure of conventional land use practice2 to accommodate these warring forces has resulted in demands for reform that, all too often, are nurtured more by apocalyptic rhetoric than by deliberate reflection. For most of this century constitutional jurisprudence exacerbated
BIJECTIONS ON RIORDAN OBJECTS

The Riordan Numbers are an integer sequence closely related to the well-known Catalan Numbers [2]. They count many mathematical objects and concepts. Among these objects are the Riordan Paths, Catalan Partitions, Interesting Semiorders, Specialized Dyck Paths, and Riordan Trees. That these objects have been shown combinatorially to be counted by the same sequence implies that a bijection exists between each pair. In this paper we introduce algorithmic bijections between each object and the Riordan Paths. Through function composition, we thus construct 10 explicit bijections: one for each pair of objects.
Evaluation of Nutritional Status and Heavy Metals Toxicity for Asthmatic Children

The present study aimed to investigate blood heavy metals toxicity for asthmatic children and their nutritional status. One hundred children suffering asthma attending the Al-Galaa Teaching Hospital during winter were enrolled in the study. Data was collected by personal interview with their mothers to fill a special questionnaire sheet (socioeconomic and clinical characteristics, anthropometric measurements and 24h dietary recall). Results showed most parents had (10–12 years) of education levels. The majority of fathers were smoking at the same room with their children. All children had high blood levels of lead (B-Pb) and cadmium (B-Cd). Most children were intake less than 50% of DRI from fiber, vitamins (A, D, B1 and B2) and minerals (K and Mg). There were a negative significant correlation between B-Pb and both Hb and animal protein (r = 0.312 and r = 278, P ˂0.05, respectively). There were a significant correlation between B-Cd and bilirubin (r = -0.381, P ˂0.05). Also, there were adverse significant correlation between plasma K and both urea and creatinine (P ˂0.01). It is concluded preventing heavy metals poisoning in early childhood is an essential component of strategy to improve the health success.
Recent Advances for Enhancing Drug Metabolizing Functions of Hepatocyte- like Cells Derived from Human Pluripotent Stem Cells

Clinical treatment for chronic liver failure using human embryonic stem cell (hESC) and human-induced pluripotent stem cell (hiPSC)-derived hepatocyte-like cells (HLCs) is considered a promising alternative method to organ transplantation. In addition to their use for treatment in liver failure, stem cell-derived HLCs have been considered for in vitro drug screening and toxicology researches [1]. Therefore, HLCs directly induced from hESCs have been intensively studied, resulting in a significant improvement in the efficiency of hepatic differentiation using human pluripotent stem cells. Albumin-positive HLCs can now be produced at the end of in vitro hepatic differentiation at levels up to 90% [2,3]. However, in spite of efforts to induce further maturation of HLCs derived from human pluripotent stem cells, the phenotype of most HLCs is more similar to fetal hepatocytes rather than fully mature hepatocytes. Critical inducing mature hepatocyte functions, such as phase I and II enzyme activity, tend to be significantly reduced in 2D-cultured HLCs (approximately <1% of human primary hepatocytes) [4,5]. Furthermore, under in vitro culture conditions, hepatobiliary transporter expression rapidly decreases [6], and most HLCs are spontaneously differentiate into various cell lineages, regardless of the differentiation protocol. Thus, at the final stage of hepatic differentiation, purification is needed to obtain highly homogenous HLCs. These key differences between HLCs and human primary hepatocytes result in limited use of HLCs as Hanyang Med Rev 2015;35:196-206 http://dx.doi. org/10.7599/hmr.2015. 35.4. 196
Deep Learning for Star-Galaxy Classification

Conventional star-galaxy classifiers are based on the reduced summaries provided by the star-galaxy catalogs. However, these classifiers need careful feature selection and involvement of domain experts at various stages of classification. Thus, the current mechanism is not extremely scalable. It is important to develop a scalable probabilistic classifier based on source information with minimal involvement of humans to overcome these shortcomings. In this project we tried to implement CNN based binary star-galaxy classifier proposed by [1].
Molecular Fingerprinting and Selection of Appropriate Media for Rapid In Vitro Multiplication of Three Yam Varieties

selection of a crop variety for dissemination, it is vital to have a system that will permit the ability to trace the product. Genomic fingerprinting is one such tools that when used can facilitate variety identification. This study uses SSR Microsatellites to establish the molecular identity of three released yam varieties alongside 21 other yam accessions comprising species Dioscorea rotundata, D. cayenensis, D. bulbifera, D. alata, D. dumentorum, and D. esculenta. The documentation of this information will enable the researcher to identify their samples at any point in time and also provide genetic relatedness information that is vital for breeding.
Radiotherapy and Chemotherapy Treatments in Head and Neck Cancer Patients — Protocol for Management Before, During and After RTP

The term oral cancer is used as a synonym for squamous cell carcinoma, which constitutes 90% of malignant neoplasms. Surgery, radiotherapy and chemotherapy are the election treatments. The selection of an only treatment or combination depends principally on the location of the tumour, its size, histological subtype, stage and the patient's general state of health. Surgery and RTP tend to be used alone to treat cases of non-metastatic disease (stages I and II), whereas more advanced cancers (III and IV) are treated by surgery in combination with radiotherapy and/or chemotherapy. It is important to bear in mind that the surgeries these patients undergo are aggressive. They provoke aesthetic and functional alterations that affect the patient’s quality of life.
Liver Involvement in Hodgkin's Lymphoma: Types of Injuries and Therapeutic Implications

The hepatocytolysis raises questions on following therapeutic conduct when it occurs during chemotherapy for Hodgkin's lymphoma, expression of its liver toxicity. But the onset of primary liver Hodgkin's lymphoma, including the form manifested by acute liver failure, poses even greater problems, as in the case of occurrence of vanishing bile duct syndrome expression of a paraneoplastic syndrome, hemophagocytic lymphohistiocytosis, peliosis hepatis or association of lymphoma with infection with hepatitis viruses or human immunodeficiency virus or different autoimmune diseases. This review summarizes the clinical experience acquired on the relationship between Hodgkin's lymphoma and liver, from the point of view of clinical manifestations, used treatments and clinical evolution. Suggestions on the course of treatment in patients with Hodgkin's lymphoma and liver damage have been formulated starting from the metabolism and elimination of chemotherapy drugs and taking into account the clinical experience of published clinical trials and cases. This review is a synthesis of knowledge obtained in this field, during the time, of therapeutic possibilities and limits, and formulates potential future milestones for research.
The effect of the decreased expression of dicer-like proteins 2 and 4 on cyclic viral titer, and short interference RNA in Cucumber mosaic virus infected tobacco plants

When infected with Cucumber mosaic virus (CMV), infected tobacco plants developed cyclic patterns of mosaic and mottle symptoms interspersed with symptomless leaves along the stem of individual plants. To determine the virus-plant interaction, the CMV viral coat protein (CP) and short interference RNA (siRNA) in CMV-infected tobacco were analyzed. A cyclical accumulation of CP was detected in young developing leaves of non-transgenic plants, but not in DCL2/4i transgenic plants. Northern blot analysis showed that CMV-specific siRNA of young developing leaves varied based on leaf position, and was not related to symptom severity in fully expanded leaves.
Nucleolar Stress: hallmarks, sensing mechanism and diseases

The nucleolus is a prominent subnuclear compartment, where ribosome biosynthesis takes place. Recently, the nucleolus has gained attention for its novel role in the regulation of cellular stress. Nucleolar stress is emerging as a new concept, which is characterized by diverse cellular insult-induced abnormalities in nucleolar structure and function, ultimately leading to activation of p53 or other stress signaling pathways and alterations in cell behavior. Despite a number of comprehensive reviews on this concept, straightforward and clear-cut way criteria for a nucleolar stress state, regarding the factors that elicit this state, the morphological and functional alterations as well as the rationale for p53 activation are still missing. Based on literature of the past two decades, we herein summarize the evolution of the concept and provide hallmarks of nucleolar stress. Along with updated information and thorough discussion of existing confusions in the field, we pay particular attention to the current understanding of the sensing mechanisms, i.e., how stress is integrated by p53. In addition, we propose our own emphasis regarding the role of nucleolar protein NPM1 in the hallmarks of nucleolar stress and sensing mechanisms. Finally, the links of nucleolar stress to human diseases are briefly and selectively introduced.
Detection of Chloroalkanes by Surface-Enhanced Raman Spectroscopy in Microfluidic Chips

Optofluidics, a research discipline combining optics with microfluidics, currently aspires to revolutionize the analysis of biological and chemical samples, e.g., for medicine, pharmacology, or molecular biology. In order to detect low concentrations of analytes in water, we have developed an optofluidic device containing a nanostructured substrate for surface enhanced Raman spectroscopy (SERS). The geometry of the gold surface allows localized plasmon oscillations to give rise to the SERS effect, in which the Raman spectral lines are intensified by the interaction of the plasmonic field with the electrons in the molecular bonds. The SERS substrate was enclosed in a microfluidic system, which allowed transport and precise mixing of the analyzed fluids, while preventing contamination or abrasion of the highly sensitive substrate. To illustrate its practical use, we employed the device for quantitative detection of persistent environmental pollutant 1,2,3-trichloropropane in water in submillimolar concentrations. The developed sensor allows fast and simple quantification of halogenated compounds and it will contribute towards the environmental monitoring and enzymology experiments with engineered haloalkane dehalogenase enzymes.
Visual information encoding for face recognition : sparse coding vs vector quantization

In this paper, we investigate the problem of visual information encoding for face recognition. We consider two models of information encoding based on sparse coding and vector quantization and compare their performance and computational complexity. The optimal solution is considered from the point of view of the best achievable classification accuracy by minimizing the probability of error under a given class of distortions. The results from the computer simulations confirm that our approach achieves similar performance with state-of-the-art sparse coding based image classification methods but with the considerably lower complexity.
A Possible Framework for the Design of Learning Programs in Assistive Technology for People with Intellectual Disabilities in Inclusive Educational Environments

In an inclusive society, people with Intellectual Disabilities (ID) are socially connected and fully participate in all realms of life, including education and employment. In a digital society being able to use technology for learning and working is a condition for participation and not remaining behind. For that reason, efforts should be made to assure that all citizens have access to technology and are helped, if needed, to develop their digital skills. The objective of this paper is to provide a framework for designing learning programs addressed to people with ID. The aims of these programs would be to support the development of digital skills and enable the use of Assistive Technologies (AT) or the combination of Information Communication Technology and AT (ICT-AT). The framework provided is based on the European funded project “Keeping Pace with Assistive Technology (KPT)” that was adapted for the specific target group of people with ID.
Down-expression of homeobox A 9 promotes cancer cell invasion in human hepatocellular carcinomas

Metastasis is the most important contributor to the mortality ofpatients with hepatocellular carcinomas (HCCs), but the molecular basis for this is unknown. Previous studies had found that homeobox A9 (HOXA9) wasfrequently methylated in HCCs; however, little is known about whether HOXA9 can influence the malignant properties of HCC cells and the exhaustive mechanisms in HCC progression. In a screen of 82 patients with HCCs, we found that HOXA9 protein expression was inversely correlated with invasion, lymphnode metastasis, and poor clinical outcomes. Silencing HOXA9 in HCC cells increased their neoplastic properties invitro and in vivo, markedly increasing the migratory, invasive, and metastatic capabilities of malignant cells. In contrast, ectopic expression of HOXA9 in HCC cells inhibited these processes. We also found that HOXA9 promoted the expression of E-cadherin and inhibited the expression of N-cadherin. These observations contribute to our understanding of the important roles of HOXA9 in HCC development and progression and HOXA9 could be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC.