Miracle-dz/UniFAR-FTUs huggingface dataset:
The Carboxyl-terminal Region of STAT3 Controls Gene Induction by the Mouse Haptoglobin Promoter*

Haptoglobin (HP) is one of the major acute phase plasma proteins in the mouse, and its synthesis is additively induced by interleukin (IL)-6 and glucocorticoids. STAT3 serves as the mediator of the IL-6 receptor signal and appears to contribute to the transcriptional induction of acute phase protein genes. The carboxyl-terminal region of STAT3, consisting of an acidic domain and containing a serine phosphorylation site, has been proposed to contribute to the induction process. To assess the role of STAT3 in the transcriptional control of the HP promoter, we applied two mutant forms of STAT3: one with a deletion of the carboxyl-terminal 55 amino acid residues, STAT3Δ55C, and the other with a substitution of serine 727 to alanine, STAT3SA. Like the wild-type STAT3, both mutant STAT3 forms are activated by the signal-transducing subunit of the IL-6 receptor, gp130, or by co-transfected IL-3 receptor. Ectopic expression and activation of wild-type STAT3 or STAT3SA in HepG2 hepatoma cells similarly enhance transcription through the IL-6-response element of the HP promoter. This enhancement is specific for STAT3 and cannot be reproduced by STAT1 or STAT5. In contrast, STAT3Δ55C inhibits IL-6-induced transcriptional activation. Interestingly, whereas receptor-activated STAT3 also enhances stimulation of the haptoglobin promoter by dexamethasone through the glucocorticoid receptor, activated STAT3Δ55C reduces the regulation below the level achieved by the glucocorticoid receptor alone. This transdominant action by STAT3Δ55C is dependent on a functional IL-6-responsive element. The data suggest that the carboxyl-terminal domain, but not its serine phosphorylation site of STAT3, is required for transcription as part of the hematopoietin receptor signaling as well as for cooperation with other transcription factors such as the glucocorticoid receptor.
Multiscale segmentation and approximation for significant description of 2D contours

This paper proposes a new approach for the multiscale segmentation and approximation of 2D contours. Its ultimate goal is to find the best set of constant curvature segments (straight line segments and/or circular arcs) to describe the contour in a way that respects its actual shape for recognition purposes. This approach is strictly based on discrete geometry principles, and the resulting algorithm named MuscaGrip (multiscale segmentation and contour approximation based on the geometry of regular inscribed polygons) computes, at multiple scales, two grouping processes.
Failure to Predict Hemolysis and Hyperbilirubinemia by IgG Subclass in Blood Group A or B Infants Born to Group O Mothers

OBJECTIVE. Direct antibody titer–positive, blood group A or B neonates who are born to group O mothers may be at risk for hemolysis and hyperbilirubinemia. Immunoglobulin G1 and immunoglobulin G3 subclasses are associated with increased hemolysis relative to immunoglobulin G2 and immunoglobulin G4. We investigated whether identification of immunoglobulin G subclass 1 or 3 may be predictive of hemolysis and hyperbilirubinemia. METHODS. Direct antibody titer-positive, blood group A and B neonates born to group O mothers were tested for the presence of immunoglobulin G subclasses 1 and 3 in umbilical cord blood by using a commercially available gel testing technology. By inference, neonates in whom neither immunoglobulin G1 nor immunoglobulin G3 were detected were designated immunoglobulin G2 and/or 4. Mandatory plasma total bilirubin was measured at discharge, and additional measurements performed as clinically indicated. Hyperbilirubinemia was defined as any plasma total bilirubin value >95th percentile for hour of life. Blood carboxyhemoglobin and total hemoglobin concentrations were also measured on the predischarge sample. Measured carboxyhemoglobin, expressed as percentage of total hemoglobin, was corrected for ambient carbon monoxide to derive “corrected carboxyhemoglobin,” a sensitive index of heme catabolism. The corrected carboxyhemoglobin/total hemoglobin ratio was calculated to correct for any differences in total hemoglobin mass between groups. RESULTS. Eighty-two infants were studied, 18 of whom were designated as immunoglobulin G1, 0 as immunoglobulin G3, and 64 as immunoglobulin G2 and/or 4. The incidence of plasma total bilirubin >95th percentile was similar between the subgroupings. Corrected carboxyhemoglobin values and corrected carboxyhemoglobin/total hemoglobin ratio were also similar between the subgroupings. CONCLUSIONS. Immunoglobulin G1 was found in 22% of direct antibody titer–positive, group A and B neonates who were born to group O mothers, whereas immunoglobulin G3 was rare. Hemolysis and hyperbilirubinemia could not be predicted by this gel technique that enabled identification of these immunoglobulin G subclasses.
On Consolidated Predictive Model of the Natural History of Breast Cancer Considering Primary Tumor and Primary Distant Metastases Growth

We propose a new mathematical growth model of primary tumor and primary metastases which may help to improve predicting accuracy of breast cancer process using an original mathematical model referred to CoM-IV and corresponding software. The CoM-IV model and predictive software: a) detect different growth periods of primary tumor and primary metastases; b) make forecast of patient survival; c) have higher average prediction accuracy than the other tools; d) can improve forecasts on survival of BC and facilitate optimisation of diagnostic tests. The CoM-IV enables us, for the first time, to predict the whole natural history of primary tumor and primary metastases growth on each stage (pT1, pT2, pT3, pT4) relying only on primary tumor sizes. Summarising: CoM-IV a) describes correctly primary tumor and primary distant metastases growth of IV (T1-4N0-3M1) stage with (N1-3) or without regional metastases in lymph nodes (N0); b) facilitates the understanding of the appearance period and manifestation of primary metastases.
Geometric accuracy of dynamic MLC tracking with an implantable wired electromagnetic transponder

Abstract Background. Tumor motion during radiotherapy delivery can substantially deteriorate the target dose distribution. A promising method to overcome this problem is dynamic multi-leaf collimator (DMLC) tracking. The purpose of this phantom study was to integrate a wired electromagnetic (EM) transponder localization system with DMLC tracking and to investigate the geometric accuracy of the integrated system. Material and methods. DMLC tracking experiments were performed on a Trilogy accelerator with a prototype DMLC tracking system. A wired implantable EM transponder was mounted on a motion stage with a 3 mm tungsten sphere used for target visualization in continuous portal images. The three dimensional (3D) transponder position signal was used for DMLC aperture adaption. The motion stage was programmed to reproduce eight representative patient-measured trajectories for prostate and for lung tumors. The tracking system latency was determined and prediction was used for the lung tumor trajectories to account for the latency. For each trajectory, three conformal fields with a 10 cm circular MLC aperture and 72 s treatment duration were delivered: (1) a 358° arc field; (2) an anterior static field; and (3) a lateral static field. The tracking error was measured as the difference between the marker position and the MLC aperture in the portal images. Results. The tracking system latency was 140 ms. The mean root-mean-square (rms) of the 3D transponder localization error was 0.53/0.54 mm for prostate/lung tumor trajectories. The mean rms of the two dimensional (2D) tracking error was 0.69 mm (prostate) and 0.98 mm (lung tumors) with tracking and 3.4 mm (prostate) and 5.3 mm (lung tumors) without tracking. Conclusions. DMLC tracking was integrated with a wired EM transponder localization system and investigated for arc and static field delivery. The system provides sub-mm geometrical errors for most trajectories.
Quantum Computational Complexity in Curved Spacetime

In this paper we examine how computational complexity analysis of quantum algorithms may be compromised when implicit assumptions of flat spacetime are violated. In particular, we show that in curved spacetime, i.e., all practical contexts, the complexity of standard formulations of Grover’s algorithm (and other iterative quantum algorithms) may reduce to that of classical alternatives. In addition, we discuss the implications of these results for quantum error correction and fault tolerant quantum computation.
A fully depleted lean-channel transistor (DELTA)-a novel vertical ultrathin SOI MOSFET

A fully depleted lean-channel transistor (DELTA) that has a gate with a vertical ultrathin SOI structure is reported. In the deep submicrometer region, selective oxidation is useful in realizing SOI isolation. It provides high crystalline quality, as good as that of conventional bulk single-crystal devices. Using experiments and three-dimensional simulation, it was shown that the gate structure has effective channel controllability and its vertical ultrathin SOI structure provides superior device characteristics. <<ETX>>
Normalization of information processing deficits in schizophrenia with clozapine.

OBJECTIVE The authors tested the hypothesis that the use of an atypical drug, clozapine, for patients with schizophrenia is related to less impairment in information processing deficits (assessed by prepulse inhibition of the startle response) than is the use of typical antipsychotics. METHOD Two groups of schizophrenic patients--receiving either clozapine or a range of typical antipsychotics--were tested for prepulse inhibition (a reduction in response to a starting stimulus, if preceded briefly by a weak, nonstartling stimulus; measured at prepulse-to-pulse intervals of 30 msec, 60 msec, and 120 msec) of the acoustic startle response and compared with a group of healthy volunteers. RESULTS Patients receiving typical antipsychotics showed less prepulse inhibition with 30-msec and 60-msec prepulse trials than did comparison subjects. Clozapine-treated patients showed normal levels of prepulse inhibition. CONCLUSIONS Clozapine is superior to typical antipsychotics in normalizing prepulse inhibition, presumably because of its pharmacological effects on prefrontal regions of the brain or its effects on a broader range of neuroreceptors.
Observer-based fuzzy control of a three phase four wire PWM inverter

It is necessary for control of a PWM inverter to consider the sinusoidal transient effect and the load unbalances distribution. This paper propose a new control method for a three phase four wire PWM inverter having an output LC filter to achieve the three phase sinusoidal voltage. An observer used to predict and estimate the state variables for one step ahead. A fuzzy controller has been used to improve the performance of the inverter and to eliminate the disturbance. The simulation results for various operation conditions demonstrate the superior performance of the proposed technique.
Retained Earnings versus Bank Financing in Intra-industry Firm Progress in East Asia: A Regional Development Model of Capitalism

The Varieties of Capitalism approach, relatively new in comparative political economy, has generated a number of studies investigating national capitalist systems and economic performances of developed countries. This approach offers a useful analytical model as it enables to study the institutional relations of firms and relations between these institutions, the so-called institutional complementarities. The most common result of the approach is the dichotomy between Liberal Market Economies, notably the United States and the United Kingdom, and Coordinated Market Economies, notably Germany, France and Japan. In this paper an attempt is made to apply the Varieties of Capitalism approach to the regional level of scale in developing countries. The province of Satun in Southern Thailand and the state of Perlis in Northern Malaysia, two bordering and peripheral regions within their respective national space economies, have been chosen as research areas. Using a modified analytical model of the Varieties of Capitalism approach, this paper tries to reveal whether and how firms cooperate with each other and how firms find access to finance. Moreover, it is investigated what institutional complementarities can be identified. It should be noted that this paper does not address institutional relations between the private and public sector. The paper starts with an outline of the Varieties of Capitalism approach and a modification for analysis at the regional level of scale in developing countries. This is followed by an economic geographical overview of Satun and Perlis. The next two sections concern the main topics: inter-firm relations and access to finance. Obviously this paper ends with some concluding remarks. Results of firm surveys in each region indicate that inter-firm relations are relatively strong in Satun, coupled with a relatively important role for banks. These results contrast with the Perlis’ case where inter-firm relations are much weaker and owners and shareholders of firms are important providers of financial capital.
Bacterial microflora of the upper gastrointestinal tract in infants without diarrhoea

The upper gastrointestinal microflora has been studied by intubation in a group of infants without diarrhoea. The aerobic flora of the nose and throat, and the aerobic and anaerobic flora of the stomach and duodenum have been defined. Prolonged duodenal intubation has been shown to increase the number of coliforms isolated and bacteriological findings after prolonged intubation should therefore be interpreted with care.
Functions of scavenger receptor class B, type I in atherosclerosis

Purpose of review This review highlights the diverse roles of the high-affinity HDL receptor scavenger receptor class B, type I (SR-BI) in the modulation of global cholesterol homeostasis and vascular cell function, and the potential implications of these processes in atherosclerosis. Recent findings SR-BI in the liver plays a critical role in reverse cholesterol transport and it dramatically impacts the characteristics of the HDL particle, and through reverse cholesterol transport it promotes an antiatherogenic lipid environment in the vascular wall. SR-BI in macrophages may influence their inflammatory phenotype. In endothelial cells, SR-BI mediates HDL-induced endothelial nitric oxide synthase activation and proliferation and migration, and in platelets SR-BI may be prothrombotic in the setting of dyslipidemia. Several polymorphisms of SR-BI have been reported in humans that influence receptor expression or function. Summary In addition to regulating global lipid metabolism, SR-BI influences the functions of a variety of vascular cells relevant to atherosclerosis. Studies of SR-BI genetics in humans partially support the conclusions drawn from experimental models. However, because of the multiple functions of SR-BI, the diversity of cell types in which it is expressed, and the influence of the receptor on the characteristics of its own ligand, our understanding of the biology of the receptor is just emerging.
Complexes between proteinase 3, α1‐antitrypsin and proteinase 3 anti‐neutrophil cytoplasm autoantibodies: a comparison between α1‐antitrypsin PiZ allele carriers and non‐carriers with Wegener's granulomatosis

To test the hypothesis that anti‐neutrophil cytoplasm autoantibodies (ANCAs) interfere with the functions of proteinase 3 (PR3) (the Wegener autoantigen) and α1‐antitrypsin (α1AT), complexes of PR3/α1AT and PR3/PR3‐ANCA‐IgG were assayed. Plasma samples were obtained from 44 patients with Wegener's granulomatosis (WG): 34 had active disease (88% ANCA positive) whereas 10 patients were in remission (20% ANCA positive). Plasma samples from 14 of the patients with active disease were also available at the time of remission. The complexes of PR3/α1AT and PR3/PR3‐ANCA‐IgG were detected by capture enzyme‐linked immunoassays (ELISAs). α1AT deficiency was evaluated by determining PiZ alleles by ELISA. Eight (18%) of the patients were PiZ positive. The frequency of this α1‐antitrypsin phenotype in the Scandinavian population is 4.7% (P < 0.001). The median PR3/α1AT complex level in the PiZ‐positive group with active disease (n = 5) was similar to the level in the PiZ‐negative group with active disease. During remission the median level for the PR3/α1AT complex was significantly higher than in the acute group (P < 0.001) including both PiZ‐positive and PiZ‐negative patients. No difference between PiZ positivity and PiZ negativity could be found in the remission group. PR3/PR3‐ANCA‐IgG complexes were found in patients with acute disease as well as in patients in remission, in almost equal frequency. This complex was also present in 13/18 ANCA‐negative samples from patients in remission. Finally, purified IgG fractions from WG patients were examined for their capacity to inhibit binding between PR3 and α1AT. An effect on the binding between PR3 and α1AT by PR3‐ANCA could not be demonstrated. Thus, our results do not support the hypothesis that PR3‐ANCA interferes with the binding between PR3 and α1AT. However, the high prevalence of the PiZ alleles among WG patients suggests that an imbalance between proteinases and α1AT may be of importance in this disease. The clinical usefulness of both the PR3/α1AT and the PR3/PR3‐ANCA‐IgG complexes and the possible influence on ANCA detection need to be examined in prospective longitudinal studies.
Cloud computing perception and success factors for information technology usage in Turkey

Cloud computing systems are widely used in the business, industry and automation for leveraging the effectiveness of the organizational operations. Cloud computing is a computer technology that enable convenient, on demand and pay-per-use access to a pool of shared resources. The benefits of cloud computing promise that automation systems can be managed effectively by utilizing cloud infrastructure. Cloud computing is one of the most important IT and systems engineering tool that enables delivering new services and value for users. Since its popularity and market size is getting higher globally, a survey is conducted in this study about cloud computing awareness, motivations, concerns, and success factors of cloud computing deployment.
Glucose-galactose malabsorption.

Primary disaccharidase deficiency isawell-known causeofdiarrhoea ininfancy. The offending disaccharide appears inthestool after ingestion due totheabsence intheintestinal mucosaoftheappropriate splitting enzyme.A muchrarercauseof diarrhoea inthis period isafailure ofabsorption of themonosaccharides, glucose andgalactose, inthe presence ofhistologically normalmucosaandfull disaccharidase activity. The clinical andbiochemical picture ofthisnewly-described entity is characteristic. Waterydiarrhoea, withglucose and/or galactose inthestools, develops within three daysofmilkfeeding andcontinues aslongasthe feeds contain these monosaccharides oranycarbohydrate composed ofthem.Carbohydrate tolerance studies showthatthepatient canabsorb fructose well, anddiarrhoea stops withsubsequent thriving whenthismonosaccharide issubstituted forother carbohydrates inthefeeds. A total of13cases hassofarbeenreported from various partsoftheworld(Laplane, Polonovski, Etienne, DeBray, Lods,andPissarro, 1962;Lindquist, 1965;Linneweh, Schaumloffel, andBarthelmai,1965;Anderson, Kerry, andTownley, 1965; Schneider, Kinter, andStirling, 1966;Marks, Norton, andFordtran, 1966; Eggermont andLoeb, 1966). Inthis paperwereport ourstudies onthe first casetobedescribed fromthis country. CaseReportt Thepatient, agirl (T.T.), wasbornatfull term, after normaldelivery, weight 3270g. Shedeveloped profusewatery diarrhoea within 2days ofbreast-feeding. Thiscontinued whenthefeeds werechanged to a
Defective Hyphal Development and Avirulence Caused by a Deletion of the SSK1 Response Regulator Gene in Candida albicans

ABSTRACT In a previous study, we reported the isolation and characterization of the two-component response regulator SSK1 gene ofCandida albicans. This gene is a structural but not a functional homolog of the SSK1 andmcs4+ genes of Saccharomyces cerevisiae and Schizosaccharomyces pombe, respectively. In the present study, we have constructed and phenotypically characterized Δssk1 mutants of C. albicans. The results confirmed our previous observation thatCaSSK1, unlike SSK1 ormcs4+, does not regulate cellular responses to either osmotic or oxidative stress. Instead, Δssk1 null strains showed severely reduced hyphal formation on serum agar and were totally defective in hyphal development on other solid media, such as medium 199 (pH 7.5) and Spider medium. In contrast, under conditions of low nitrogen availability on solid media, Δssk1 null strains dramatically hyperinvaded the agar. However, while forming germ tubes and hyphae in liquid media similar to those of the wild type, Δssk1 null strains flocculated in a manner similar to that of Δchk1 two-component histidine kinase mutants, which we have previously described. Finally, virulence studies indicated that SSK1 is essential for the pathogenesis ofC. albicans, suggesting that the Ssk1p response regulator could be a good target for antifungal therapy.
A comparative study on the nutritional status of the pre-school children of the employed women and the unemployed women in the urban slums of guntur.

BACKGROUND The early childhood development is most crucial and the mother's care and attention is essential. The inevitable changes like women entering the work field have an effect on the child care and development. AIM To study the selected anthropometric indices of the children of employed and unemployed women. SETTINGS AND DESIGN This study was done in the urban slums of Guntur city by using a cross sectional, descriptive design. METHODS AND MATERIAL This study was conducted during January - April 2011 with a sample of 312 children of non working women and 311 children of working women, who were selected through the systemic random quota sampling method in 6 randomly selected slums. The data was collected through questionnaires who were named as the Mother's schedule and the Child schedule, which consisted of close-ended questions which were coded for an easy data entry. The Mother's schedule looked at the information regarding the mother, like the caretaker during the mother's absence, the time which was spent with her child each day, etc. The Child schedule looked for information like whether the child was exclusively breast fed, its age in months when the weaning started, whether the government sponsored crèche services (Anganwadi center) were utilized, etc. It also included the anthropometrical measurements of the child like its current weight, current height and mid arm circumference, which were obtained by using standardized tools. STATISTICAL ANALYSIS For each schedule, a separate table was created in a relational basis in MS Access, with suitable key fields to connect the information for the analysis. RESULTS The children of the unemployed mothers weighed significantly higher than the children of the employed mothers. The children of the unemployed mothers also stood significantly taller than the children of the employed mothers. CONCLUSION In the absence of the mothers who are at work, a childcare service is essential and this should be facilitated through legislation, NGO efforts, etc. Breast feeding and the bonding time with children are to be encouraged for the employed mothers.