Miracle-dz/UniFAR-FTUs huggingface dataset:
Olanzapine in the treatment of agitation in hospitalized patients with schizophrenia and schizoaffective and schizofreniform disorders.

BACKGROUND Olanzapine is an atypical antipsychotic with proven therapeutic effect, though it is rarely used in agitated patients. This study was to assess the effectiveness and safety of a 20-mg initial dose of olanzapine to control agitation of hospitalized patients with schizophrenia and schizoaffective and schizofreniform disorders. MATERIAL/METHODS A group of 95 patients aged 18-65 years was observed for 7 days. Effectiveness was assessed according to the CGI and PANSS (including the positive and negative symptoms and excitement subscale PANSS-EC) scales. Adverse events were also recorded. RESULTS Two therapeutic groups were distinguished: patients treated with olanzapine alone (OLZ) and those whose condition necessitated at least one administration of benzodiazepines (OLZ + BZ). Although these groups differed with respect to baseline symptom severity, improvement was similar. In the OLZ group, improvement according to the CGI scale was observed after 2 h and persisted to the end of the study. In the OLZ + BZ group there was improvement after 1 h, but not after 2 h. Significant improvement reappeared after 6 h and persisted. Improvement measured by the PANSS-EC scale was noted in the OLZ group after 2 h and in the OLZ + BZ group after 6 h, persisting in both groups from the 12th hr to the end of the observation. CONCLUSIONS Olanzapine is an antipsychotic which, used alone or in combination with benzodiazepines, is effective and well tolerated in treatment of agitation in schizophrenic patients. Further studies are warranted.
Sex Differences in Persuadability of Human and Computer-Synthesized Speech: Meta-Analysis of Seven Studies

To examine sex differences in persuasiveness, we conducted a meta-analysis of seven studies from our laboratory on reactions to human versus computer-synthesized speech. We tested three hypotheses: (1) people would be more persuaded by human speech than by computer-synthesized speech, (2) women would be slightly more persuaded than men, and (3) the sex difference would be more pronounced for human speech than for synthetic speech. While there was support for the first two hypotheses, there was none for the third. Also, no consistent support was found for a moderating effect of mode of presentation, audio versus video.
An overview of DC microgrid operation and control

A microgrid can be defined as power cluster of distributed generation, load, and energy storage device accumulated together in the vicinity to each other. It gives opportunity to utilize renewable energy sources for green and clean environment. As the Distributed Energy Resources (DERs) are located nearby to the load, power transmission losses are minimized. The output of DERs such as PV, fuel cells is DC. In case of wind power, using power electronics devices, DC power can be obtained. The DC terminals are connected to electronic loads, electric vehicles, and batteries which form a Direct Current Microgrid. It is very important to operate and control DCMG in appropriate way to achieve more reliability, cost benefit and enhanced performance. The control objectives of DCMG are a) equal load sharing among DERs in per unit b) maintain terminal voltage constant. In this paper, an overview of literature is covered based on operation and control practices of DCMG. It can be very useful to power system engineers and researchers.
Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: a EuroSIDA study.

BACKGROUND Factors that determine the immunological response to highly active antiretroviral therapy (HAART) are poorly defined. OBJECTIVE Our aim was to investigate predictors of immunological failure after initial CD4(+) response. METHODS Data were from EuroSIDA, a prospective, international, observational human immunodeficiency virus (HIV) type 1 cohort. RESULTS Of 2347 patients with an increase in CD4(+) cell count >or=100 cells/microL within 6-12 months of the initiation of HAART, 550 (23%) subsequently experienced immunological failure (CD4(+) count less than or equal to the pre-HAART value). The incidence of failure was 11.6 incidences/100 person-years of follow-up (95% confidence interval [CI], 10.2-13.4) during the first 12 months and decreased significantly over time (P<.0001). Independent predictors of immunological failure were pre-HAART CD4(+) cell count (per 50% higher; relative hazard [RH], 2.05; 95% CI, 1.83-2.31; P<.0001), time-updated virus load (per 1 log(10) higher; RH, 1.77; 95% CI, 1.64-1.92; P<. 0001), and HIV-1 risk behavior (P=.047 for a global comparison of risk groups). CONCLUSION The risk of immunological failure in patients with an immunological response to HAART diminishes with a longer time receiving treatment and is associated with pretreatment CD4(+) cell count, ongoing viral replication, and intravenous drug use.
High Titer and Avidity of Nonneutralizing Antibodies against Influenza Vaccine Antigen Are Associated with Severe Influenza

ABSTRACT The importance of neutralizing antibody in protection against influenza virus is well established, but the role of the early antibody response during the initial stage of infection in affecting the severity of disease is unknown. The 2009 influenza pandemic provided a unique opportunity for study because most patients lacked preexisting neutralizing antibody. In this study, we compared the antibody responses of 52 patients with severe or mild disease, using sera collected at admission. A microneutralization (MN) assay was used to detect neutralizing antibody. We also developed an enzyme-linked immunosorbent assay (ELISA) which detects both neutralizing and nonneutralizing antibodies against viral antigens from a split-virion inactivated monovalent influenza virus vaccine. While the MN titers were not significantly different between the two groups (P = 0.764), the ELISA titer and ELISA/MN titer ratio were significantly higher for patients with severe disease than for those with mild disease (P = 0.004 and P = 0.011, respectively). This finding suggested that in patients with severe disease, a larger proportion of serum antibodies were antibodies with no detectable neutralizing activity. The antibody avidity was also significantly higher in patients with severe disease than in those with mild disease (P < 0.05). Among patients with severe disease, those who required positive pressure ventilation (PPV) had significantly higher ELISA titers than those who did not require PPV (P < 0.05). Multivariate analysis showed that the ELISA titer and antibody avidity were independently associated with severe disease. Higher titers of nonneutralizing antibody with higher avidity at the early stage of influenza virus infection may be associated with worse clinical severity and poorer outcomes.
A space mapping method allowing models with different parameter rank and physical meanings for coarse and fine model

Automated optimization of complex microwave circuits is still a critical task in nowadays. This contribution demonstrates two new approaches in space mapping technology. One substantial benefit is the improvement of calculation efficiency of the TRASM algorithm by enhancing the multiparameter extraction step. Furthermore, the possibility of mapping coarse and fine models of different degrees of freedom, i.e. with different parameter rank, and unequal physical parameter meanings has been introduced to the method. Therefore, arbitrary microwave circuits of high complexness with well-matching coarse models can be efficiently and automatically optimized.
A DNA vaccine encoding p39 and sp41 of Brucella melitensis induces protective immunity in BALB/c mice

ResuMeN Las especies de Brucella son bacterias gram-negativas intracelulares facultativas que pueden multiplicarse dentro celulas fagociticas y no-fagociticas en hospederos finales tanto humanos como animales. B. melitensis causa aborto en animales y fiebre ondulante en humanos. Una proteina de superficie de 41 kDa (sp41) esta asociado con la adherencia bacteriana e invasion de celulas HeLa. El rol de esta proteina es importante para la interaccion con celulas hospederas. Previamente se ha descrito el antigeno inmunodominante p39, medido por celulas T. Ambos vectores (pCIsp41 y pCIp39) indujeron la formacion de inmunoglobulinas sericas antigeno-especificas asi como una respuesta proliferativa de celulas T y una fuerte produccion de interferon gamma luego de la re-estimulacion, ya sea con los antigenos especificos o con extracto de Brucella . El nivel de proteccion fue significativo en ratones tratados con pCIp39 y pCIsp41, pero fue inferior al nivel requerido. Palabras claves : vacuna DNA,
BECN1, corpus luteum function, and preterm labor

Progesterone is a steroid hormone that is necessary to maintain pregnancy in mammals. We recently found that mice with a conditional deletion of Becn1/Beclin 1 specifically in the progesterone-synthesizing cells of the corpus luteum, had reduced progesterone synthesis and these mice failed to maintain pregnancy.1 Furthermore, we identified that lipid storage and feedback through PRLR (prolactin receptor) and LHCGR (luteinizing hormone/choriogonadotropin receptor) were negatively affected by Becn1 deletion. BECN1 is necessary for the interaction of the 2 catalytic subunits of the class III phosphatidylinositol 3-kinase complex, PIK3C3, and PIK3R4, which are responsible for the generation of phosphatidylinositol 3-phosphate that is required for nucleation of the phagophore. Work from Sun et al. and Itakura et al. demonstrated that this BECN1 complex is also necessary for the fusion of autophagosomes and endosomes with lysosomes. Therefore, we suspected that ablating Becn1 in luteal cells would inhibit macroautophagy, hereafter referred to as autophagy. In support, we provide evidence that autophagic flux is reduced in our model. Thus, this study provides evidence that Becn1 is necessary for steroid production in murine luteal cells.
Evaluation de combinaisons thérapeutiques ciblées en cancérologie des voies aérodigestives supérieures. Mise au point d’un modèle tumoral in vivo

Les cancers tete et cou ou des voies aerodifestives supereiures (VADS) representent le sixieme cancer le plus frequent dans le monde entier. Le traitement des stades avances de ces tumeurs est base sur le traitement chirurgical combinee a la radiotherapie +/- a la chimiotherapie. Toutefois , la survie a 5 ans reste faible et le developpement de nouvelles therapies ciblees est necessaire. Le F14512 combine un noyau epipodophyllotoxine de ciblage de la topoisomerase II avec un groupement spermine introduit afin de permettre de vehiculer la molecule par le STP. Ce groupement spermine facilite la captation selective par les cellules tumorales par l'intermediaire du systeme de transport de polyamine (STP) suractive dans les cellules tumorales. Nous rapportons ici l'evaluation du F14512 sur des lignees cellulaires cancereuses des VADS.Quatre lignees cellulaires representatives de l'anatomie de la tete et du cou ont ete utilises : Il s'agissait des lignees Fadu ( pharynx ), SQ20B ( larynx ), CAL33 et CAL27 ( base de la langue ). L'activite du STP et la specificite ont ete evaluees par la cytometrie en flux et la microscopie confocale en utilisant une sonde fluorescente le F17073 contenant le meme fragment spermine que le F14512. La cytotoxicite, seule ou en association avec des agents chimiotherapeutiques standards (cisplatine, 5FU), et les effets de radio-sensibilisation ont ete etudies par MTS et par des tests clonogeniques. L'activite du STP et l'efficacite du F14512 ont egalement ete mesures dans des conditions hypoxiques (1 % O2). Dans les quatre lignees testees, un STP actif a ete mis en evidence permettant un transfert rapide et specifique au noyau des composes couples a un groupement spermine. Fait interessant, le F14512 presente un effet cytotoxique 1,6 a 11 fois plus eleve que l'etoposide compose de reference (depourvu de la chaine de spermine). Il apparait egalement plus cytotoxique que le 5FU et le cisplatine dans toutes les lignees cellulaires. Des experiences de competition avec la spermine ont confirme le role essentiel du STP dans la vectorisation et la cytotoxicite du F14512. Les conditions d'hypoxie n'avait presque pas d'impact sur la cytotoxicite des molecules. La combinaison du F14512 avec le cisplatine, mais pas le 5FU, s'est revelee etre synergique et pour la premiere fois nous avons demontre le potentiel radio-sensibilisant significatif du F14512.Le groupement spermine du F14512 confere une action ciblee et une meilleure efficacite que l'etoposide sur des lignees cancereuses des VADS. L'effet synergique observe en association avec le cisplatine et la radiotherapie apparait interessant pour le developpement potentiel de F14512 en cancerologie des VADS.
Cell‐Line Specific Protection by Berry Polyphenols Against Hydrogen Peroxide Challenge and Lack of Effect on Metabolism of Amyloid Precursor Protein

Amyloid precursor protein (APP) altered metabolism, Aβ‐overproduction/aggregation and oxidative stress are implicated in the development of Alzheimer's disease pathology. Based on our previous data indicating that administration of a polyphenol‐rich (PrB) blueberry extract (from wild Vaccinium angustifolium) is memory enhancing in healthy mice and in order to delineate the neuroprotective mechanisms, this study investigated the antioxidant effects of PrB in H2O2‐induced oxidative damage, Aβ peptide fibrillogenesis and APP metabolism. PrB suppressed H2O2‐initiated oxidation (DCF assay) and cell death (MTT assay) in SH‐SY5Y cells. Protective effects were observed on Chinese hamster ovary (CHO) cells overexpressing APP770 carrying the mutation Val717Phe only at high concentrations, while further damage on HEK293 cells was induced after co‐treatment with 250 µ m H2O2 and PrB in comparison with H2O2 alone. Using the thioflavine T assay, blueberry polyphenols inhibited Aβ‐aggregation (~70%, 15 µg/mL) in a time‐dependent manner, while in the CHOAPP770 cells it had no effect on APP metabolism as assessed by western blot. The results suggest that blueberry polyphenols exhibit antioxidant and/or pro‐oxidant properties according to the cellular environment and have no effect on APP metabolism. Copyright © 2011 John Wiley & Sons, Ltd.
Predicting Pragmatic Reasoning in Language Games

Who's Who Different languages rely on distinct sets of terminology to classify relatives, such as maternal grandfather in English, and precision in language usage is a key component for successful communication (see the Perspective by Levinson). Kemp and Regier (p. 1049) propose an organizing framework whereby kinship classification systems can all be seen to optimize or nearly optimize both simplicity and precision. The labels applied to kin are constructed from simple units and are precise enough to reduce confusion and ambiguity when used in communication. Frank and Goodman (p. 998) show that simplicity and precision also explain how listeners correctly infer the meaning of speech in the context of referential communication. A Bayesian inference model predicts how listeners decode communications. One of the most astonishing features of human language is its capacity to convey information efficiently in context. Many theories provide informal accounts of communicative inference, yet there have been few successes in making precise, quantitative predictions about pragmatic reasoning. We examined judgments about simple referential communication games, modeling behavior in these games by assuming that speakers attempt to be informative and that listeners use Bayesian inference to recover speakers’ intended referents. Our model provides a close, parameter-free fit to human judgments, suggesting that the use of information-theoretic tools to predict pragmatic reasoning may lead to more effective formal models of communication.
Impact of climate change on global malaria distribution

Significance This study is the first multimalaria model intercomparison exercise. This is carried out to estimate the impact of future climate change and population scenarios on malaria transmission at global scale and to provide recommendations for the future. Our results indicate that future climate might become more suitable for malaria transmission in the tropical highland regions. However, other important socioeconomic factors such as land use change, population growth and urbanization, migration changes, and economic development will have to be accounted for in further details for future risk assessments. Malaria is an important disease that has a global distribution and significant health burden. The spatial limits of its distribution and seasonal activity are sensitive to climate factors, as well as the local capacity to control the disease. Malaria is also one of the few health outcomes that has been modeled by more than one research group and can therefore facilitate the first model intercomparison for health impacts under a future with climate change. We used bias-corrected temperature and rainfall simulations from the Coupled Model Intercomparison Project Phase 5 climate models to compare the metrics of five statistical and dynamical malaria impact models for three future time periods (2030s, 2050s, and 2080s). We evaluated three malaria outcome metrics at global and regional levels: climate suitability, additional population at risk and additional person-months at risk across the model outputs. The malaria projections were based on five different global climate models, each run under four emission scenarios (Representative Concentration Pathways, RCPs) and a single population projection. We also investigated the modeling uncertainty associated with future projections of populations at risk for malaria owing to climate change. Our findings show an overall global net increase in climate suitability and a net increase in the population at risk, but with large uncertainties. The model outputs indicate a net increase in the annual person-months at risk when comparing from RCP2.6 to RCP8.5 from the 2050s to the 2080s. The malaria outcome metrics were highly sensitive to the choice of malaria impact model, especially over the epidemic fringes of the malaria distribution.
International Conference on Knowledge-Based and Intelligent Information & Engineering Systems-KES 2014 Signal learning with messages by reinforcement learning in multi-agent pursuit problem

Communication is a key for facilitating multi-agent coordination on cooperative problems. Reinforcement learning is one of the learning methods for such cooperative behavior of agents. Kasai et al. proposed Signal Learning (SL) and Signal Learning with Messages (SLM) by which agents learn policies of communication and action concurrently in multi-agent reinforcement learning framework. In this study, we experimented that the performance of the SLM is better than SL to pursuit problem where agents can observe only partial information and can move four directions. As a result, it has been shown that learning performance in SLM with longer messages is better than SL. c © 2014 The Authors. Published by Elsevier B.V. Peer-review under responsibility of KES International.
Surveillance and outbreak reports Pandemic influenza A ( H 1 N 1 ) 2009 in Morocco : experience of the Mohammed V Military Teaching Hospital , Rabat , 12 June to 24 December 2009

I Lahlou Amine (idr_lahlou@yahoo.com)1, T Bajjou1, H El Rhaffouli1, A Laraqui1, F Hilali1, K Menouar1, K Ennibi2, M Boudlal2, E A Bouaiti3, K Sbai3, M Rbai3, M Hachim2, S Zouhair1 1. University Mohammed V-Souissi, Faculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, Biosafety Level 3 and Research Laboratory, Rabat, Morocco 2. University Mohammed V-Souissi, Faculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, Department of Internal Medicine, Rabat, Morocco 3. Royal Armed Forces’ Health Services, Division for Health and Safety Surveillance, Rabat, Morocco
Validation of a Stages of Exercise Change Questionnaire

Abstract The purpose of this study was to examine evidence for the validity of a stages of change measure of the Transtheoretical Model for exercise behavior. Participants were 152 university students (53.3% women, 71.6% Caucasian, M age = 19.18 years) who completed processes of change, self-efficacy, decisional balance, stages of change, and exercise behavior questionnaires as well as a maximal treadmill test. Participants in the action and maintenance stages had the highest strenuous (PC/C/P < A/M) and moderate (PC/C < A/M) self-reported exercise behavior. Those in the maintenance stage had the highest estimated aerobic fitness (PC/P < M). The differences between the early stages (PC, C, and P) and the later stages (A and M) as described by the first function were primarily due to the behavioral process of change. The differences between the extreme stages (PC and M) and the middle stages (C, P, and A) were due to the experiential processes of change and the pros of decisional balance. The hypothesized patterns ofstage differences were partially supported. Failure to obtain full support may have been due to methodological issues or inherent difficulties in detecting evidence for the validity of stages of change measures.
Effect of Water Soluble Polymer, Polyethyleneglycol, and Glass-Forming Compounds on Cell Fusion

Abstract The cell fusion of Molt T-cells was investigated in the presence of water soluble polymer, polyethyleneglycol (PEG) and glass-forming monomers. In cell fusion with PEG only, inactivation of the cell occurred within 2 min. However, in the presence of PEG and water soluble polymer, most of the fused and unfused cells lived even after fusion times of more than 10 min. It was observed that water soluble polymer prevented the inactivation of cells during fusion as a protectant. As the result, ratio of fused cells increased in the presence of water soluble polymers. Some glass-forming monomers used as new fusogens such as M-23G (n = 23) and M-50G (n = 50) monomers having long oxyethylene chains in the methoxypolyethyleneglycol methacrylate, CH3O-(-CH2CH2-O)n-CO-C(CH3)=CH2 as well as PEG #2000 indicated large promoting and protecting effects on cell fusion.
How complete is PER?

The category of partial equivalence relations (PER) on the natural numbers has been used extensively in recent years to model various forms of higher-order type theory. It is known that PER can be viewed as a category of sets in a nonstandard model of intuitionistic Zermelo-Fraenkel set theory. The use of PER as a vehicle for modeling-type theory then arises from completeness properties of this category. The paper demonstrates these completeness properties, and shows that, constructively, some complete categories are more complete than others. <<ETX>>
ICHTHYOFAUNA COMPOSITION ACROSS A WAVE - ENERGY GRADIENT ON SOUTHERN BRAZIL BEACHES

Wave action in sandy beach surf zones and its influence on species composition were evaluated at three sites at Pontal do Parana, Parana State, between June/2004 and May/2005. At each sampling site, five hauls were performed monthly using a 15 m long, 2.6 m height beach seine with a 5 mm mesh-size. Samplings were carried out at low water spring tides during daylight. A total of 26,866 fishes were collected, amounting to a total weight of 84,838 kg, which were distributed amongst 28 families and 63 taxa. Multi- and univariated methods used indicated that sheltered and moderately exposed beach samples had similar ichthyofaunal composition, being clupeids and engraulids the most abundant at these beaches. Although abiotic factors differed significantly between beaches, depth appears to exert the major influence on ichthyofauna structure by providing less turbulent waters which might have permitted shoals maintenance. Conversely, exposed beach samples differed largely from the other beaches and were influenced primarily by wave height and salinity variables. These were displayed at CCA diagram and through the occurrence of P. virginicus, M. littoralis and T. goodei.