Miracle-dz/UniFAR-FTUs huggingface dataset:
Reverse Engineering Distributed Applications: an Event Abstraction Tool

Understanding the behavior of distributed applications is a very challenging task due to the complexity of these applications. To manage complexity, the top-down use of suitable abstraction hierarchies is frequently proposed. Given the complexity of distributed applications, manually deriving such abstraction hierarchies is not realistic. The execution of distributed applications is typically analyzed using an event-based approach. This paper discusses one tool that groups more primitive events into abstract events to derive a hierarchy of abstract events automatically. Ideally, these abstractions should reveal logical units of an application and their relations. To explore the abstraction hierarchies derived, an existing prototype visualization tool was modified to provide abstract visualizations. A user can navigate through these abstraction hierarchies, displaying an execution at various levels of abstraction. Examples of such abstract visualizations are given and discussed. In general, the abstractions derived automatically represent meaningful parts of the application: they can be interpreted in terms of the application domain. While the abstraction tool does not necessarily derive the best possible abstraction hierarchies in all cases, it performs the bulk of the work and provides good initial abstractions which can subsequently be refined manually.
Production of tumor necrosis factor-alpha and interleukin-6 in mice infected with group B streptococci.

Group B streptococci (GBS) are a leading cause of sepsis and meningitis in neonates. Since cytokines are thought to play an important role in septic shock, we have studied serum levels of tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6) in BALB/c mice infected with type III GBS. TNF alpha and IL-6 were detected by the L929 cytotoxicity and the B9 proliferation assays, respectively, in serial serum samples obtained after infection. After i.p. challenge with an LD50, serum TNF alpha rose above baseline values as early as 3 hr, peaked at 7 hr, and returned to baseline values at 20 hr. IL-6 serum levels rose concomitantly with TNF alpha, peaking 8 hr after challenge. No serum TNF alpha activity was detected in the course of sublethal infections. However, a transient rise in TNF alpha levels was observed after i.v. inoculation of high numbers (greater than or equal to 1 x 10(8) of heat-killed GBS. When groups of mice were injected i.v. with a single dose of anti-TNF alpha rabbit serum 2 hr before challenge with an LD90 or LD30, no effect was noted in terms of survival, although the serum TNF alpha peak was completely abrogated. Serum TNF alpha does not seem to play an obligatory role in GBS-induced lethality of adult mice. However, further studies are needed to assess better the role of this cytokine in the pathogenesis of GBS sepsis.
Bringing an inpatient palliative care program to a teaching hospital: lessons in leadership.

This feature provides a platform for oncology nurses to illustrate the many ways that leadership may be realized and professional practice may transform cancer care. Possible submissions include but are not limited to overviews of projects, interviews with nurse leaders, and accounts of the application of leadership principles or theories to practice. Descriptions of activities, projects, or action plans that are ongoing or completed are welcome. Manuscripts should clearly link the content to the impact on cancer care. Manuscripts should be six to eight doublespaced pages, exclusive of references and tables, and accompanied by a cover letter requesting consideration for this feature. For more information, contact Associate Editor Paula Klemm, PhD, RN, OCN, at klemmpa@udel.edu or Associate Editor Judith K. Payne, PhD, RN, AOCN, at payne031@mc.duke. edu Paula T. Rieger, RN, MSN, AOCN®, FAAN Associate Editor
RESOLUÇÃO DE PROBLEMAS NA ATENÇÃO AMBULATORIAL DA ESQUIZOFRENIA

Com a reforma psiquiatrica, muitas familias de portadores de transtornos mentais passaram a enfrentar problemas relacionados a atencao ambulatorial. Este artigo analisa verbalizacoes de resolucao para problemas da atencao ambulatorial da esquizofrenia, em familias de usuarios de um CAPS tipo II, ocorridas no contexto de uma discussao, interpretando quais verbalizacoes atuariam como regras na resolucao dos problemas identificados. Participaram da pesquisa cinco familias de classe popular, com renda variando de 2 a 4 salarios minimos. As interacoes verbais dos familiares foram gravadas em video, transcritas e analisadas, a partir da teoria sobre comportamento verbal na resolucao de problema e comportamento verbalmente mediado (regras), proposta pelo Behaviorismo Radical. Os resultados obtidos indicaram que o comportamento agressivo do usuario e sua recusa em tomar a medicacao foram, dentre todas as situacoes identificadas como problemas, aquelas verbalizadas por todas as familias participantes. As verbalizacoes de resolucao geralmente foram generalizacoes de acoes bem sucedidas em ocasioes vividas pelas familias, e os dados sugeriram que suas formulacoes em alguns casos atuam como regra no enfrentamento de problemas semelhantes.
An informal satisfaction survey of 200 patients after laser in situ keratomileusis.

PURPOSE Patient satisfaction following laser in situ keratomileusis (LASIK) is commonly reported as high. This paper reviews the outcome of LASIK both in terms of visual results and satisfaction. METHODS Two-hundred patients were surveyed telephonically to establish their degree of satisfaction with LASIK and to enquire about postoperative use of glasses, and symptoms of light sensitivity and of night vision problems. Patient anonymity was assured. RESULTS The majority of patients (95%) never wore distance glasses after LASIK. Reading glasses were used by 49 (24.5%), related to age and presbyopia. Light sensitivity was not a problem or was unchanged from baseline in 73% of patients; 27% said they were worse; a few (5.5%) said their symptoms were better. Night vision was not a problem or was unchanged from baseline in 76% of patients; 24% said they were worse; 17% said their symptoms were better. One hundred ninety-five patients (97.5%) were extremely happy with their results and 197 (98.5%) would have the procedure again. CONCLUSION After LASIK, 95% of 200 patients wore no distance optical correction; 99% would have the procedure again; and light sensitivity and night vision problems bothered a significant number of patients.
Throttling Capacity Sharing Using Life Time and Reuse Time Prediction in Private L2 Caches of Chip Multiprocessors

In Chip Multi-Processors (CMPs), private L2 caches have potential benefits in future CMPs, e.g. small access latency, performance isolation, tile-friendly architecture and simple low bandwidth on-chip interconnect. But the major weakness of private cache is the higher cache miss rate caused by small private cache capacity. To deal with this problem, private caches can share capacity through spilling replaced blocks to other private caches. However, indiscriminate spilling can make capacity problem worse and influence performance negatively. This letter proposes throttling capacity sharing (TCS) for effective capacity sharing in private L2 caches. TCS determines whether to spill a replaced block by predicting reuse possibility, based on life time and reuse time. In our performance evaluation, TCS improves weighted speedup by 48.79%, 6.37% and 5.44% compared to non-spilling, Cooperative Caching with best spill probability (CC) and Dynamic Spill-Receive (DSR), respectively. key words: Chip Multi-Processors, private L2 cache, capacity sharing, cooperative caching
Are Somatic Symptoms and Related Distress More Prevalent in Hispanic/Latino Youth? Some Methodological Considerations

This article comments on the current status of the anxiety literature involving Latino children and adolescents. As the 2 articles that focus on Hispanic/Latino youth in this special section independently found somatic symptoms to be more prevalent in Latino youth than other racial/ethnic groups (Pina & Silverman, this issue; Varela et al., this issue), this commentary discusses methodological considerations for guiding future anxiety research and makes suggestions for clinicians who treat Latino children and adolescents.
La autorregulación transcripcional en la optimización y ensamblaje de los motivos de red bacterianos

Esta tesis presenta los resultados obtenidos en tres trabajos que versan sobre la autorregulaciOn y los motivos de red: el primero pone el foco en un modulo funcional concreto, el sistema SOS de E. coli; el segundo estudio abarca la red transcripcional completa de esta misma bacteria; y el tercero, la practica totalidad de los organismos procariotas cuyos genomas han sido secuenciados. Tratamos pues con tres estudios realizados a escalas o niveles biologicos de organizaciOn de muy distinto orden de magnitud.
Financial Stability Indicators – The Case of Croatia1

Abstract This paper considers financial stability through the processes of accumulation and materialisation of systemic risks. To this end, the method of principal component analysis on the example of Croatia has been used to construct two composite indicators – a systemic risk accumulation index and an index reflecting the consequences of systemic risk materialisation. In the construction of the indices, the features and risks specific to small open economies were considered. Such an approach to systemic risk analysis facilitates the monitoring and understanding of the degree of financial stability and communication of macroprudential policy makers with the public.
Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site*

Background: Atg9 vesicles are directly involved in autophagosome formation. Results: Mass spectrometric analysis revealed that Atg9 vesicles contain vesicle-tethering proteins Trs85 and Ypt1. These proteins localize to the autophagosome formation site in an Atg9-dependent manner. Conclusion: Atg9 vesicles play a role in the recruitment of the vesicle-tethering machinery. Significance: This study is the first proteomics study of Atg9 vesicles. Atg9 is a transmembrane protein that is essential for autophagy. In the budding yeast Saccharomyces cerevisiae, it has recently been revealed that Atg9 exists on cytoplasmic small vesicles termed Atg9 vesicles. To identify the components of Atg9 vesicles, we purified the Atg9 vesicles and subjected them to mass spectrometry. We found that their protein composition was distinct from other organellar membranes and that Atg9 and Atg27 in particular are major components of Atg9 vesicles. In addition to these two components, Trs85, a specific subunit of the transport protein particle III (TRAPPIII) complex, and the Rab GTPase Ypt1 were also identified. Trs85 directly interacts with Atg9, and the Trs85-containing TRAPPIII complex facilitates the association of Ypt1 onto Atg9 vesicles. We also showed that Trs85 and Ypt1 are localized to the preautophagosomal structure in an Atg9-dependent manner. Our data suggest that Atg9 vesicles recruit the TRAPPIII complex and Ypt1 to the preautophagosomal structure. The vesicle-tethering machinery consequently acts in the process of autophagosome formation.
Direction of arrival estimation based on time-modulated antenna array

The application of time-modulated antenna arrays (TMAAs) in direction of arrival (DOA) estimation is investigated in this paper. The classical multiple signal classification (MUSIC) algorithm in DOA estimation is deformed to suit for the TMAAs. Moreover, a method of combining the MUSIC algorithm and differential evaluation (DE) and genetic algorithm (GA) is proposed to avoid fake peaks, improve the probability of resolution and decrease angle error of DOA estimation. Simulation results of the DOA estimation with an 8-element time-modulated linear array (TMLA) are presented which show the proposed method has better performance than conventional uniform linear array (ULA). Moreover, an experiment of DOA estimation based on TMLA is carried out to give a further verification of the application of TMAA in DOA estimation.
Lean ERP: A hybrid approach Push /Pull

ERP (Enterprise Resource Planning) and Lean Manufacturing are two production methods. The evolution of the industrial sector has led companies to review their strategies on the application of the two methods. ERP vendors are beginning to recognize the power and benefits of Lean Manufacturing, hence the idea of combining these two principles of production which gave birth to hybrid system Push/Pull. In this article, we review the Lean Manufacturing and ERP, their evolution, reasons of their application and the relationship between Lean, ERP and Push/Pull systems. The aim is to clarify the meaning of push/pull in manufacturing systems. This clarification gives rise to a frame push/pull which can be used as the basis of our hybrid system.
Historical time to disease progression and progression‐free survival in patients with recurrent/refractory neuroblastoma treated in the modern era on Children's Oncology Group early‐phase trials

Early‐phase trials in patients with recurrent neuroblastoma historically used an objective “response” of measureable disease (Response Evaluation Criteria In Solid Tumors [RECIST], without bone/bone marrow assessment) to select agents for further study. Historical cohorts may be small and potentially biased; to the authors' knowledge, disease recurrence studies from international registries are outdated. Using a large recent cohort of patients with recurrent/refractory neuroblastoma from Children's Oncology Group (COG) modern‐era early‐phase trials, the authors determined outcome and quantified parameters for designing future studies.
An Empirical Evaluation of Normalization Methods for MicroRNA Arrays in a Liposarcoma Study

Background Methods for array normalization, such as median and quantile normalization, were developed for mRNA expression arrays. These methods assume few or symmetric differential expression of genes on the array. However, these assumptions are not necessarily appropriate for microRNA expression arrays because they consist of only a few hundred genes and a reasonable fraction of them are anticipated to have disease relevance. Methods We collected microRNA expression profiles for human tissue samples from a liposarcoma study using the Agilent microRNA arrays. For a subset of the samples, we also profiled their microRNA expression using deep sequencing. We empirically evaluated methods for normalization of microRNA arrays using deep sequencing data derived from the same tissue samples as the benchmark. Results: In this study, we demonstrated array effects in microRNA arrays using data from a liposarcoma study. We found moderately high correlation between Agilent data and sequence data on the same tumors, with the Pearson correlation coefficients ranging from 0.6 to 0.9. Array normalization resulted in some improvement in the accuracy of the differential expression analysis. However, even with normalization, there is still a significant number of false positive and false negative microRNAs, many of which are expressed at moderate to high levels. Conclusions Our study demonstrated the need to develop more efficient normalization methods for microRNA arrays to further improve the detection of genes with disease relevance. Until better methods are developed, an existing normalization method such as quantile normalization should be applied when analyzing microRNA array data.
Harmonic suppressed differential phase shifter

For the first time, a broadband differential phase shifter with harmonic suppression is proposed. The proposed structure is not only used to provide a constant differential phase shift over the desired wide bandwidth, but also have a significant harmonic band rejection at the same time. Design formulas for the structure are derived using a systematic analytic technique. The optimal design parameters for different typical differential phase shift values are provided to allow for a quick design procedure. To illustrate the principles, a broadband 45° phase shifter is designed, fabricated and measured. It achieved excellent performance with small insertion loss, small phase deviation and good out of band rejection.
Engineering the smarts: An illustration of the disconnect between control engineering and AI

The design and analysis of smart system behavior needs to bridge between worlds - both with regard to engineering methods and to the technologies central to adaptivity and thus a core functionality of smart systems-of-systems. We illustrate this in our domain, smart buildings, where AI technologies like rule based or probabilistic reasoning set the strategies that define the building's adaptive behavior, but control loops firmly set in control engineering implement it. However, we observe an apparent disconnect between these approaches. Using demand response (DR, the change of consumption patterns in response to global demand) as an example, we illustrate consequences of such mono-disciplinary thinking that both academic researchers and engineering practitioners are prone to. Specifically, we show how adaptive behavior couples previously independent dynamics and how reacting to these dynamics may lead to emerging unintended system state changes and non-acceptable performance. We argue for stringent links between system design and analysis based on probabilistics and simulation, as adaptivity in cyber physical systems needs the best from both AI and control engineering.
Decisions by Conscious Persons about Controlled NHBD after Death: Eyes Wide Open

Michael A. DeVita, MD, is Assistant Medical Director of the Institute for Performance Improvement, and is an Assistant Professor of Anesthesiology/Critical Care Medicine and Internal Medicine at the University of Pittsburgh Medical Center and the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania. Thomas May, PhD, is the Director of the Clinical Ethics Center and is an Adjunct Professor in the Department of Medical Humanities at the Memorial Medical Center and the Southern Illinois University School of Medicine in Springfield, Illinois.
Critical Protection from Renal Ischemia Reperfusion Injury by CD55 and CD591

Renal ischemia-reperfusion injury (IRI) is a feature of ischemic acute renal failure and it impacts both short- and long-term graft survival after kidney transplantation. Complement activation has been implicated in renal IRI, but its mechanism of action is uncertain and the determinants of complement activation during IRI remain poorly understood. We engineered mice deficient in two membrane complement regulatory proteins, CD55 and CD59, and used them to investigate the role of these endogenous complement inhibitors in renal IRI. CD55-deficient (CD55−/−), but not CD59-deficient (CD59−/−), mice exhibited increased renal IRI as indicated by significantly elevated blood urea nitrogen levels, histological scores, and neutrophil infiltration. Remarkably, although CD59 deficiency alone was inconsequential, CD55/CD59 double deficiency greatly exacerbated IRI. Severe IRI in CD55−/−CD59−/− mice was accompanied by endothelial deposition of C3 and the membrane attack complex (MAC) and medullary capillary thrombosis. Complement depletion in CD55−/−CD59−/− mice with cobra venom factor prevented these effects. Thus, CD55 and CD59 act synergistically to inhibit complement-mediated renal IRI, and abrogation of their function leads to MAC-induced microvascular injury and dysfunction that may exacerbate the initial ischemic assault. Our findings suggest a rationale for anti-complement therapies aimed at preventing microvascular injury during ischemia reperfusion, and the CD55−/−CD59−/− mouse provides a useful animal model in this regard.
Effect of heterologous expression of acyl-CoA-binding protein on acyl-CoA level and composition in yeast.

We have expressed a bovine synthetic acyl-CoA-binding protein (ACBP) gene in yeast (Saccharomyces cerevisiae) under the control of the GAL1 promoter. The heterologously expressed bovine ACBP constituted up to 6.4% of total cellular protein and the processing was identical with that of native bovine ACBP, i.e. the initiating methionine was removed and the following serine residue was N-acetylated. The expression of this protein did not affect the growth rate of the cells. Determination of the yeast acyl-CoA pool size showed a close positive correlation between the ACBP content of the cells and the size of the acyl-CoA pool. Thus ACBP can act as an intracellular acyl-CoA pool former. Possible physiological functions of ACBP in cells are discussed.
Monotonicity properties and spectral characterization of power redistribution in cascading failures

In this work, we apply spectral graph theory methods to study the monotonicity and structural properties of power redistribution in a cascading failure process. We demonstrate that in contrast to the lack of monotonicity in physical domain, there is a rich collection of monotonicity one can explore in the spectral domain, leading to a systematic way to define topological metrics that are monotonic. It is further shown that many useful quantities in cascading failure analysis can be unified into a spectral inner product, which itself is related to graphical properties of the transmission network. Such graphical interpretations precisely capture the Kirchhoff's law expressed in terms of graph structural properties and gauge the impact of a line when it is tripped. We illustrate that our characterization leads to a tree-partition of the network so that failure cascading can be localized.
Q-integralidade do Grafo Total de Kn

Grafos Q-integrais sao grafos cujo espectro em relacao a matriz laplaciana sem sinal e constituido somente por numeros inteiros. A caracterizacao geral dos grafos com esta propriedade e um problema bem dificil. Ao mesmo tempo que se busca grafos Q-integrais tambem e interessante encontrar operacoes que preservem a Q-integralidade dos grafos, ou seja, operacoes que quando aplicadas em grafos Q-integrais gerem novos grafos Q-integrais. Sabemos que os grafos completos sao Q-integrais [1]. Nossa contribuicao consiste em mostrar que a operacao grafo total quando aplicada em um grafo completo preserva a Q-integralidade do mesmo, ou seja, gera um novo grafo Q-integral.