Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients.

PURPOSE To evaluate the impact of miR-155 on the outcome of adults with cytogenetically normal (CN) acute myeloid leukemia (AML) in the context of other clinical and molecular prognosticators and to gain insight into the leukemogenic role of this microRNA. PATIENTS AND METHODS We evaluated 363 patients with primary CN-AML. miR-155 levels were measured in pretreatment marrow and blood by NanoString nCounter assays that quantified the expression of the encoding gene MIR155HG. All molecular prognosticators were assessed centrally. miR-155-associated gene and microRNA expression profiles were derived using microarrays. RESULTS Considering all patients, high miR-155 expression was associated with a lower complete remission (CR) rate (P < .001) and shorter disease-free survival (P = .001) and overall survival (OS; P < .001) after adjusting for age. In multivariable analyses, high miR-155 expression remained an independent predictor for a lower CR rate (P = .007) and shorter OS (P < .001). High miR-155 expressers had approximately 50% reduction in the odds of achieving CR and 60% increase in the risk of death compared with low miR-155 expressers. Although high miR-155 expression was not associated with a distinct microRNA expression profile, it was associated with a gene expression profile enriched for genes involved in cellular mechanisms deregulated in AML (eg, apoptosis, nuclear factor-κB activation, and inflammation), thereby supporting a pivotal and unique role of this microRNA in myeloid leukemogenesis. CONCLUSION miR-155 expression levels are associated with clinical outcome independently of other strong clinical and molecular predictors. The availability of emerging compounds with antagonistic activity to microRNAs in the clinic provides the opportunity for future therapeutic targeting of miR-155 in AML.
Remote Attestation on Function Execution

A program is a compound of various subroutines playing different roles. In this paper, we study how to attest the execution of those mission-critical subroutines whose execution is the basis to establish trust. Our results include a new attestation scheme called function attestation. Given a function F of a program P , the proposed scheme allows for an efficient and secure attestation by using the debug facility of processors and building a trust chain rooted at TPM. Our scheme is lightweight and easy to deploy. It can also be easily extended to support multiple-threaded programs and data flow attestation with slightly more overhead.
Molecular characterization of an 11q interstitial deletion in a patient with the clinical features of Jacobsen syndrome

The 11q terminal deletion disorder or Jacobsen syndrome is a contiguous gene disorder. It is characterized by psychomotor retardation, cardiac defects, blood dyscrasias (Paris‐Trousseau syndrome) and craniofacial anomalies. We report on a female patient with an approximately 10 Mb interstitial deletion with many of the features of Jacobsen syndrome: A congenital heart defect, dysmorphic features, developmental delay, and Paris‐Trousseau syndrome. The karyotype of the patient is 46,XX,del(11)(q24.1q24.3). The interstitial deletion was confirmed using FISH probes for distal 11q, and the breakpoints were characterized by microarray analysis. This is the first molecularly characterized interstitial deletion in a patient with the clinical features of Jacobsen syndrome. The deletion includes FLI‐1, but not JAM‐3, which will help to determine the critical genes involved in this syndrome. © 2006 Wiley‐Liss, Inc.
Transforming growth factor‐α accelerates hepatocyte repopulation after hepatocyte transplantation

Background and Aim: Although hepatocyte transplantation could be an alternative to orthotopic liver transplantation, many problems, such as rejection, location, required volume, and hepatocyte activity are currently unresolved. We previously demonstrated an anti‐apoptotic effect in transgenic mice overexpressing transforming growth factor (TGF)‐α. We herein present the details of a successful hepatocyte transplantation using TGF‐α transgenic mice.
Urine osmolality and conductivity as indices of hydration status in athletes in the heat.

PURPOSE The purpose of this study was to determine a quick and easy method for assessment of day-to-day hydration status in athletes in the heat. METHODS Measurement of the osmolality of the first urine sample of the day collected after wakening but before breakfast established a standardized collection procedure to allow day-to-day comparisons of individuals. RESULTS Laboratory measurements established that a difference in osmolality is found when individuals are dehydrated by a moderate extent in comparison with an euhydrated situation: the osmolality of the first morning urine sample of control subjects (N = 11) averaged over 5 d was 675 (+/- 232) mosmol.kg-1 (mean +/- SD). For subjects who were hypohydrated by exercise followed by fluid restriction, morning urine osmolality was 924 (+/- 99) mosmol.kg-1 (P < 0.001, N = 11, averaged over 7 d). Field measurements from 29 athletes undertaking warm weather training indicated that the athletes could, with appropriate feedback, maintain a satisfactory hydration status. Athletes in weight category sports tended to record a higher morning urine osmolality, reflecting their attempts to dehydrate: recorded values were 627 (+/- 186) mosmol.kg-1 (nonweight category sports, N = 8), 775 (+/- 263) mosmol.kg-1 (boxers, N = 15) and 777 (+/- 254) mosmol.kg-1 (wrestlers, N = 6). Results obtained with a hand-held portable conductivity were compared with those from measured osmolality. CONCLUSIONS The findings suggest that such an instrument could provide athletes with reliable information as to their hydration status from measurement of the first morning urine of the day and therefore provide a quick and easy method for achieving an approximation of hydration status from day-to-day.
Evaluation of a Lactation Support Service in a Children's Hospital Neonatal Intensive Care Unit

Breastfeeding hospitalized infants can be difficult. The authors assessed the effectiveness of an International Board Certified Lactation Consultants (IBCLC) service to increase the proportion of infants given their own mother's milk (OMM) in a children's hospital neonatal intensive care unit (NICU). The charts of 350 randomly selected patients admitted the year before and after implementation of the service in July 1997 were abstracted. Factors significantly associated with infants being given OMM included infant sex, ethnicity, length of NICU stay, and 5-minute Apgar score. After comparison of the periods before and after pro-gram implementation, the proportion of NICU infants ever given their OMM was found to have increased from 31% to 47% (P = .002). This increase differed significantly in relation to infants' clinical status and/or management (5-minute Apgar score, length of NICU stay, and age at NICU admission) but not in relation to maternal factors. Mothers with infants in the NICU should have access to lactation counseling. J Hum Lact. 19(3):286-292.
Musculoskeletal disorders among rural Australian nursing students.

AIM To investigate the prevalence of musculoskeletal disorders (MSD) among rural Australian nursing students and compare the results with other international studies. METHOD AND ANALYSIS A self-reporting questionnaire adapted from previous research, was administered to 260 students from all three grades of a major nursing school in regional north Queensland, Australia. RESULTS A high proportion of students reported an MSD at some body site (80.0%), with low back pain being the most common condition (59.2%). This was followed by MSD of the neck (34.6%), knee (25.0%), shoulder (23.8%), feet (16.5%), wrist (12.7%) and legs (11.9%). MSD of the shoulder was slightly more common among males when compared to females (39.3% vs 22.0%, P = 0.0424). Previous paid employment as a nurse or nursing assistant was found to increase the risk of upper arm MSD by a factor of 10.8 (odds ratio 10.8, 95% confidence interval 1.9-205.8, P = 0.0276). CONCLUSION Overall, this investigation suggests that MSD is more frequent among rural Australian nursing students, when compared to their counterparts around the world. Their high rate of MSD is also comparable to that reported by hospital nurses in other countries.
Predictors of freezing in Parkinson's disease: A survey of 6,620 patients

Data from a survey of 6,620 Parkinson's disease patients were examined for correlation of freezing with age, sex, duration, subjective severity of Parkinson's disease, and antiparkinsonian medication. Forty‐seven percent of the patients reported experiencing freezing regularly. Logistic regression analysis showed that freezing was significantly associated with a longer disease duration and a more advanced stage of the disease. Freezing episodes were more likely in men than in women and in patients taking, in addition to levodopa, Entacapone, Amantadine, or dopamine agonists. Finally, patients considering tremor as their main symptom reported freezing less frequently. Common antiparkinsonian drugs given in combination with levodopa were not negatively correlated with freezing. The results underline the necessity to develop appropriate countermeasures against this phenomenon, which is widely known to cause significant impairment of patients' quality of life and—as our data also showed—may cause traffic accidents in licensed patients. © 2007 Movement Disorder Society
Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: Predictive value for subsequent development of persistent wheezing

Infants with acute bronchiolitis during the first months of life are at increased risk of developing persistent wheezing and bronchial asthma later in life. The study of eosinophil cationic protein (ECP) suggests that eosinophil‐related inflammatory mechanisms may play a role in respiratory syncytial virus (RSV) bronchiolitis. The aim of our study was to verify whether serum ECP (s‐ECP) measurements are useful in predicting the development of persistent wheezing in children affected by RSV bronchiolitis during a 5 years follow‐up period. Forty‐eight infants were enrolled prospectively (mean age: 153.5 days). All had a clinical and radiological diagnosis of acute bronchiolitis and confirmed RSV infection. Peripheral eosinophil counts, levels of s‐ECP, and serum IgE concentrations were measured during bronchiolitis. Five years later the children were re‐evaluated in regard to their respiratory symptoms (standardized questionnaires) and atopic status (specific IgE levels).
Distributed in-memory SPARQL Processing via DOF Analysis

Using so-called triple patterns as building blocks, SPARQL queries search for specified patterns in RDF data. Although many aspects of the challenges faced in large-scale RDF data management have already been studied in the database research community, current approaches provide centralized DBMS (or disk) based solutions, with high consumption of resources; moreover, these exhibit very limited flexibility dealing with queries, at various levels of granularity and complexity (e.g., SPARQL queries involving UNION or OPTIONAL operators). In this paper we propose a computational in-memory framework for distributed SPARQL query answering, based on the notion of degree of freedom of a triple. This algorithm relies on a general model of RDF graph based on the first principles of linear algebra, in particular on tensorial calculus. Experimental results show that our approach, utilizing linear algebra techniques can process analysis efficiently, when compared to recent approaches.
TEORÍA Y PRÁCTICA DE LOS ENFOQUES TÁCTICOS EN LA ENSEÑANZA DEL DEPORTE EN EL ÁMBITO ESCOLAR (II) THEORY AND PRACTICE OF GAME-BASED APPROACHES IN SHOOL CONTEXT (II) PRÓLOGO - FOREWORD

Desde las publicaciones clave de los anos 80 (Bunker & Thorpe, 1982; Thorpe, Bunker & Almond, 1986), donde se publica el modelo Teaching Games for Understanding (TGfU) y los principales principios pedagogicos que lo fundamentan, los escritos en torno a la Ensenanza Comprensiva del Deporte (ECD)1 han proliferado progresivamente, suponiendo actualmente un importante apartado dentro de la literatura sobre Educacion Fisica y, en menor medida, del entrenamiento deportivo.
Protective CD4+ and CD8+ T Cells against Influenza Virus Induced by Vaccination with Nucleoprotein DNA

ABSTRACT DNA vaccination is an effective means of eliciting both humoral and cellular immunity, including cytotoxic T lymphocytes (CTL). Using an influenza virus model, we previously demonstrated that injection of DNA encoding influenza virus nucleoprotein (NP) induced major histocompatibility complex class I-restricted CTL and cross-strain protection from lethal virus challenge in mice (J. B. Ulmer et al., Science 259:1745–1749, 1993). In the present study, we have characterized in more detail the cellular immune responses induced by NP DNA, which included robust lymphoproliferation and Th1-type cytokine secretion (high levels of gamma interferon and interleukin-2 [IL-2], with little IL-4 or IL-10) in response to antigen-specific restimulation of splenocytes in vitro. These responses were mediated by CD4+ T cells, as shown by in vitro depletion of T-cell subsets. Taken together, these results indicate that immunization with NP DNA primes both cytolytic CD8+ T cells and cytokine-secreting CD4+ T cells. Further, we demonstrate by adoptive transfer and in vivo depletion of T-cell subsets that both of these types of T cells act as effectors in protective immunity against influenza virus challenge conferred by NP DNA.
EEG Emotion Recognition in Videogame Play

This study explores emotion recognition in videogames using electroencephalographic (EEG) data. Presently, emotion recognition using pattern recognition techniques has not yet been investigated in videogame play. This research is motivated by the possibility of retrieving insights into player experience from EEG signal during gameplay, which aims to contribute to Games User Research as an emerging discipline in the study of videogame design and their interaction with the players. In order to investigate emotion recognition several approaches for feature vector creation and classification algorithms were employed in order to assess which combination offered higher accuracy in classification. A maximum of 33.48% of classification accuracy was achieved by the Nearest Mean Classifier in the classification of four different emotions. Such low results suggests the collection and pre-processing of data from a dynamic activity, such as videogame play demands novel approaches for filtering the EEG, rejecting of artifacts and selection of the emotional model into which map the EEG brainwave oscillations.
The coupled atom transistor

We describe the first implementation of a coupled atom transistor where two shallow donors (P or As) are implanted in a nanoscale silicon nanowire and their electronic levels are controlled with three gate voltages. Transport spectroscopy through these donors placed in series is performed both at zero and microwave frequencies. The coherence of the charge transfer between the two donors is probed by Landau–Zener–Stückelberg interferometry. Single-charge transfer at zero bias (electron pumping) has been performed and the crossover between the adiabatic and non-adiabatic regimes is studied.
A pharmacist-guided protocol for improved monitoring of patients on antidepressants.

BACKGROUND Local guidelines recommend that patients treated for depression receive 3 follow-ups within 12 weeks of antidepressant initiation; however, this is often not achieved in practice. METHODS A monitoring protocol was implemented as a quality improvement project at Wingra Access Medical Center in which patients treated for anxiety or depression received a follow-up phone call 1 to 2 weeks after starting an antidepressant. RESULTS A retrospective chart review demonstrated the percentage of patients achieving 3 follow-ups within 12 weeks significantly increased from 7% to 24% following implementation. CONCLUSION Results suggest the protocol is a feasible method to improve antidepressant followup in primary care. Confounding factors including cohort dissimilarities and introduction of a behavioral health service should be considered.
In vitro steroid-induced meiosis in Rhinella arenarum oocytes: role of pre-MPF activation

Summary In this work we showed the relationship between seasonal periods and the response of R. arenarum follicles and oocytes to different steroids. Using in vitro germinal vesicle breakdown (GVBD) assays, we demonstrated that P4 is the main steroid capable of inducing maturation in R. arenarum oocytes and follicles. In the second part of this work we showed that androgens can activate pre-maturation promoting factors (pre-MPFs) such as P4, by cytoplasm microinjection experiments. The results indicated that the steroids assayed induced oocyte and follicle maturation in a dose- and time-dependent manner. In oocytes, P4 was the most efficient steroid as a maturation inducer (EC50 of the reproductive period, 6 nM, EC50 of the non-reproductive period ≅ 30 nM). Androgens (DHEA, dehydroepiandrosterone; T, testosterone; and AD, androstenedione) were less efficient maturation inducers than P4 (EC50 reproductive period ≅ 50, 120 and 600 nM respectively). Similar results were obtained with intact follicles in both seasonal periods. Although the response of follicles to the different androgens was variable, in no case was it above the above the response induced by P4. Independently of the season, oocytes and follicles incubated in P4, P5 and T underwent GVBD after 6–10 h while oocytes and follicles incubated in DHEA and AD matured more slowly. Furthermore, we demonstrated that microinjection of mature cytoplasm from androgen-treated oocytes is sufficient to promote GVBD in immature recipient oocytes (DHEA, 57 ± 12%; AD, 60 ± 8%; T, 56 ± 13%). Thus, androgens such as DHEA, T and AD are as competent as P4 to activate pre-MPF.
Understanding Filipino Adolescents: Research Gaps and Challenges

Maiksi subalit masalimuot ang panahon ng kabataan sa buhay ng tao. Ang suliranin ng pagsasaayos sa mga problemang kaakibat nito ay nangangailangan ng ganap na pag-unawa sa kabataang Pilipino ng kasalukuyang panahon. Nais ibahagi ng papel na ito ang pagtutukoy sa mga mahahalagang isyu na karaniwang di natugunan sa mga nauna nang pag-aaral. Ilan sa mga suliraning pampananalikssik ay binigyang pansin at inaasahang mapupunan ang mga puwang na patuloy pa ring naiiwan sa larangan. Ang mga kakulangang nais tugunan ay ang mga sumusunod na usapin: pagkakaisa sa pagpapakahulugan sa konsepto ng “kabataan” at sekswalidad; di-kumpletong datos ukol sa ugnayan ng bilang ng kabataan at bilang ng kabuuang populasyon; antas ng kamalayan ng mga stakeholders at kabataan mismo tungkol sa paglaki ng bilang ng huli; ang pangangailangan ng mga stakeholders ng napapanahon at bagong pagkaunawa tungkol sa antas, mga tagapagtakda, at kahihinatnan ng sekswalidad ng kabataan, pati ng kanilang fertility at reproductive health; at, ang kanilang kamalayan at pakikilahok sa mga gawaing panlipunan. Ilan sa mga rekomendasyon ay ang pagkakaroon ng pambansang sarbey sa mga bagong erya ng pag-aaaral kaakibat ang kwalitatibong pananaliksik, pananaliksik pampatakaran (policy research) at operations research. Ang artikulo ay isang pagtatangka sa paghahanap ng mga pamamaraan upang maimulat sa mga kabataan at sa lipunang Pilipino ang kahalagahan ng maturidad at pagbibigay ng mga safety nets sa ating mga kabataan bilang gabay sa transisyunal na panahong ito sa pagitan ng kanilang pagiging mamamayan na may sapat na gulang.
A history of research on yeasts 13. Active transport and the uptake of various metabolites1

Introduction: evidence that substrates can enter by active transport 689 Concentrative solute uptake: active transport and proton symport 691 Uptake of sugars 694 Hexoses 694 Disaccharides 695 Uptake of amino acids 698 Regulation 700 Transport into yeast vacuoles 703 Transport into various yeast species 705 Hexoses 705 Glycosides 707 Carboxylic acids 709 Conclusion 716 Acknowledgements 718 References 718
Investigation of financial market prediction by recurrent neural network

Recurrent neural networks as fundamentally different neural network from feed-forward architec- tures was investigated for modelling of non linear behaviour of financial markets. Recurrent neural networks could be configured with the correct choice of parameters such as the number of neurons, the number of epochs, the amount of data and their relationship with the training data for predictions of financial markets. By exploring of learning and forecasting of the recurrent neural networks is observed the same effect: better learning, which often is described by the root mean square error does not guarantee a better prediction. There are such a recurrent neural networks settings where the best results of non linear time series fore- casting could be obtained. New method of orthogonal input data was proposed, which improve process of EVOLINO RNN learning and forecasting.
Flexible Data Dissemination Strategy for Effective Cache Consistency in Mobile Wireless Communication Networks

In mobile wireless communication network, caching data items at the mobile clients is important to reduce the data access delay. However, efficient cache invalidation strategies are used to ensure the consistency between the data in the cache of mobile clients and at the database server. Servers use invalidation reports (IRs) to inform the mobile clients about data item updates. This paper proposes and implements a multicast based strategy to maintain cache consistency in mobile environment using AVI as the cache invalidation scheme. The proposed algorithm is outlined as follows - To resolve a query, the mobile client searches its cache to check if its data is valid. If yes, then query is answered, otherwise the client queries the DTA (Dynamic Transmitting Agent) for latest updates and the query is answered. If DTA doesn't have the latest updates, it gets it from the server. So, the main idea here is that DTA will be multicasting updates to the clients and hence the clients need not uplink to the server individually, thus preserving the network bandwidth. The scenario of simulation is developed in Java. The results demonstrate that the traffic generated in the proposed multicast model is simplified and it also retains cache consistency when compared to the existing methods that used broadcast strategy.
Le monde est clos et le désir infini

a croissance economique est devenue intermittente, fugitive. A l'image du climat, elle alterne le chaud et le froid, les booms et les krachs. La crise du monde occidental doit beaucoup plus qu'on n'est generalement pret a l'admettre a sa disparition. Que font les hommes politiques ? Comme les sorciers qui veulent faire tomber la pluie, ils levent les mains vers le ciel pour la faire venir, aiguisant le ressentiment des peuples quand elle n'est pas au rendez-vous. Mais que deviendrait la societe moderne si la promesse d'une croissance perpetuelle s'averait vaine ? Saurait-elle trouver d autres satisfactions, ou tomberait-elle dans le desespoir et la violence ? Preferera-t-elle vivre au-dessus de ses moyens, tant ecologiques que psychiques, plutot que d'y renoncer ? Telles sont les questions brulantes posees par cet essai, qui nous entraine dans un surprenant voyage au c ur des mecanismes qui ont fait advenir la societe moderne, de l'invention de la richesse a la revolution numerique.