Miracle-dz/UniFAR-FTUs huggingface dataset:
The A‐ and B‐type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

Cyclins play a key role in the induction of mitosis. In this paper we report the isolation of a cyclin A cDNA clone from Xenopus eggs. Its cognate mRNA encodes a protein that shows characteristic accumulation and destruction during mitotic cell cycles. The cyclin A polypeptide is associated with a protein that cross‐reacts with an antibody against the conserved ‘PSTAIR’ epitope of p34cdc2, and the cyclin A‐cdc2 complex exhibits protein kinase activity that oscillates with the cell cycle. This kinase activity rises more smoothly than that of the cyclin B‐cdc2 complexes and reaches a peak earlier in the cell cycle; indeed, cyclin A is destroyed before nuclear envelope breakdown. None of the cyclin‐cdc2 complexes show simple relationships between the concentration of the cyclin moiety and the kinase activity. All three cyclin associated kinases (A, B1 and B2) phosphorylate identical sites on histones with the consensus XSPXK/R, although they show significant differences in their substrate preferences. We discuss possible models for the different roles of the A‐ and B‐type cyclins in the control of cell division.
Factors Affecting Visitors' Interest Towards Financial Portals

With the interference of internet in our day to day life, surfing the websites and portals for necessary information has become a key habit of every individual. In the same order, the financial portals play vital role in providing key information and valuable suggestions to the investors, market participants and academicians. Though there are many financial portals on the internet, hardly any of them is able to fulfill the expectations and requirements of visitors’. This research is aimed at knowing the expectations of visitors from an ideal financial portal and finding the factors which affect their interest in visiting a financial portal. This will help the researcher to know the behavior of visitors and accordingly redesign a financial portal.In the research, the responses of individual visitors/users of the financial portals have been analyzed through factor analysis, cross tabulation etc. and concluded that most of the visitors visit a financial portal for the information regarding the Stock market. The factors identified in the researcher that attract the visitors’ interest in a financial portal are Contents, Design, Display, Interaction and References. Therefore, the moderator of a financial portal should concentrate on delivering the appropriate and authenticated information on the portal.
Human resources management, service delivery and the job satisfaction/alienation paradox: a hospitality industry perspective.

This review clarifies and defines the role ofHRM in a hospitality context concluding its position as a 'map' or philosophy rather than a series of prescriptive procedures. The absence of holistic HRM strategies in many hospitality organisations is noted and held responsible for these challenges including inconsistent service delivery, low wages, low skills and high levels of labour turnover. It then considers the characteristics of the industry (including seasonality) and its labour market and discusses the apparent job satisfaction/alienation paradox. Some key explanatory theses are advanced including inherent entrepreneurial behaviours of workers, the marginal worker and affluent worker constructs and the occupational community phenomenon known to exist in organisations with impoverished and unsupportive styles of management. A review of current HRM practice reveals that the historical HR situation has changed little over the last several years.
Implementation of a PDA based program to quantify urology resident in-training experience.

INTRODUCTION There currently is no simple and reliable mechanism for Residency program directors to assess how well their trainees are being exposed to all spheres of their specialty. We report on the use of hand-held personal digital assistants (PDA's) to document all clinical and academic activities of urology residents at one academic institution. MATERIALS AND METHODS Software was developed to create customized pick lists allowing residents to record all activities on their individual PDA's. Categories included Adult Ambulatory, Pediatric Ambulatory, Adult operative, Pediatric operative, and Academic. Activities were subcategorized into detailed pick lists and time-tracking fields. Residents synchronized with a central database on a standalone hotsync server. RESULTS In the first 8 months, 21 178 resident-hours and 5333 activities were recorded. Preliminary observations can be made regarding how residents spend the majority of their time: 28% operative, 20% self-study, 19% ward work, 10% Academics, 6% ER consultations, 5% clinic, and 4% inpatient consultations. The most common adult diagnoses encountered while attending to clinic, ward, or ER consultations were lower urinary tract symptoms, urolithiasis and hematuria. Similarly for Pediatrics: neurogenic bladder, antenatal hydronephrosis, infection, and hypospadias were most often reported. Residents reported 5,333 activities, relating to the following spheres of Urology: academics (23%), endourology (18%), oncology (15%), lower urinary tract symptoms (10%), congenital anomalies (5%), urolithiasis (5%), reconstruction (5%), and infection (3%). CONCLUSIONS This tool provides an objective assessment of resident experience as it relates to selection of rotations, and for addressing curriculum weaknesses. It is applicable at a national level for the study of regional differences in training experience, and trends in graduate Urological education. With minimal effort it could be modified for application to other specialty training programs.
Value-Relevance of Banks' Fair Value Disclosures Under SFAS No. 107

This study provides evidence that fair value estimates of loans, securities and long-term debt disclosed under SFAS No. 107 provide significant explanatory power for bank share prices beyond that provided by related book values. In contrast to Eccher et al. (1996) and Nelson (1996), we consistently find incremental explanatory power for loans' fair values. Relatively stronger findings are obtained using a set of significant conditioning variables, including nonperforming loans, and interest-sensitive assets and liabilities. The joint significance of these loan-related variables and loans' fair values indicates that loans' fair values do not reflect completely loan default and interest rate risk. The loans coefficient is significantly larger for banks with higher regulatory capital, which is consistent with market participants discounting unrealized gains on loans disclosed by less healthy banks. The findings are robust with respect to the inclusion of additional explanatory variables and to a first differences formulation.
Optimal body fat percentage cut‐offs for obesity in Chinese adults

Obesity results in an increased risk of metabolic syndrome (MetS) and Type 2 diabetes (T2DM). Body fat percentage (BF%) is a common index of body composition. The aim of the present study was to determine the optimal BF% cut‐offs for obesity to predict MetS and T2DM in Chinese adults. The baseline study group comprised 3916 Chinese adults (age 30–70 years of age); 2033 subjects without MetS or T2DM were followed up for a maximum of 5.5 years. The BF% was estimated using bioelectrical impedance analysis. Optimal BF% cut‐offs were analysed by receiver operating characteristic (ROC) curves. Binary logistic regression analysis was performed to measure the association between obesity at baseline defined by BF% and newly developed MetS and T2DM. Mean BF% levels were lower in men than in women (23.9 ± 6.1% vs 33.5 ± 7.1%, respectively; P < 0.01). For men, the optimal BF% cut‐offs for the prediction of MetS and T2DM were 25.45% and 26.65%, respectively; for women, the corresponding values were 34.95% and 36.55%. Subjects with high BF% (≥ 25% in men; ≥ 35% in women) had higher risks of incident MetS or T2DM than those with low BF% (< 25% in men; < 35% in women). The relative risks were 3.43 (95% confidence intervals (CI) 2.59–4.54) and 2.92 (95% CI 1.85–4.60), respectively. The optimal BF% cut‐offs for obesity for the prediction of MetS and T2DM in Chinese men and women were around 25% and 35%, respectively.
Word-of-mouth Communication in Low-risk Product Decisions

Word-of-mouth communication is an elusive but powerful market force. While past studies of word of mouth have concentrated on high-risk products, this study demonstrates the power of word of mouth in influencing low-risk purchase decisions. The results indicate that word of mouth does not operate in isolation but in conjunction with media information sources. They also show that word-of-mouth behaviour is not random but is reinforced by needs of both informers and informees.
A Semantic Web Service Discovery System Based on UDDI and OWLS

As a popular registry for Web services, UDDI provides a mature mechanism for service registration and search, but it does not support semantic operations on Web services, so its service discovery capability is not satisfactory. OWL-S overcomes UDDI’s shortcomings. Using OWL-S, service advertisements and requests based on capability description could be built in a uniform way, and the semantic matching between them could also be achieved. By means of these two technologies, a system was developed which is compatible with UDDI and supports the publication and discovery of semantic Web services. The matching performed by the system is divided into two parts: prematching and post-matching. The pre-matching is generally performed only in the course of service publication, so the time for service discovery is reduced. Experimental results show that the performance of the system is reliable. Furthermore, the system can produce query results ordered by priority according to the requester’s expectations.
Radiation damage in soft X-ray microscopy

The rates of chemical transformation by radiation damage of polystyrene (PS), poly(methyl methacrylate) (PMMA), and fibrinogen (Fg) in a X-ray photoemission electron microscope (X-PEEM) and in a scanning transmission X-ray microscope (STXM) have been measured quantitatively using synchrotron radiation. As part of the method of dose evaluation in X-PEEM, the characteristic (1/e) sampling depth of X-PEEM for polystyrene in the C 1s region was measured to be 4 ± 1 nm. Critical doses for chemical change as monitored by changes in the X-ray absorption spectra are 80 (12), 280 (40) and 1230 (180) MGy (1 MGy = 6.242*! eV/nm3, where ! is the polymer density in g/cm3) at 300 eV photon energy for PMMA, Fg and PS, respectively. The critical dose for each material is comparable in X-PEEM and STXM and the values cited are thus the mean of the values determined by X-PEEM and STXM. C 1s, N 1s and O 1s spectroscopy of the damaged materials is used to gain insight into the chemical changes that soft X-rays induce in these materials. © 2008 Elsevier B.V. All rights reserved.
Unbundling the effects of institutions on firm resources: The contingent value of being local in emerging economy private equity

How do host country institutions influence the value of a firm's local resources? Using a novel dataset on the performance of 47 private equity (PE) firms in 49 emerging economies, we show evidence that the answer depends on the type of institution. Focusing on conditions at the time of initial investment, we find that PE firms with local origins and foreign PE firms with local experience performed better when contract enforcement institutions were weak than when they were strong. Financial development, in contrast, may have undermined the value of PE firm local origins. These results help reconcile contrasting findings on how host country institutions influence performance and lead us to contend that unbundling institutions is necessary for continued development of the institutions-based view
Unmanned loading operation by autonomous wheel loader

Authors developed a real sized autonomous wheel loader “Yamazumi-4,” and succeeded to execute the unmanned and autonomous task including excavating, scooping a pile, hauling and loading it on a dump truck, appearing in the mining work typically. This paper describes on the whole task control that consists of pile position measurement by stereo vision, path planning, path following control, pile excavating control, and loading control.
A coordination mechanism based on a combined technique applied to dynamic Packet scheduling in routers

This paper describes an approach which uses a machine learning model in a packet scheduling problem to improve the end-to-end delay. A good Packet scheduling discipline allows to achieve QoS differentiation and to optimize the queuing delay. In a dynamically changing environment this discipline should be also adaptive to the new traffic conditions. We model this problem as a multi-agent system which consists of a whole of autonomous learning agents that interact with the environment. We define the learning problem as a decentralized process using a general mathematical framework, namely Markovian Decision Processes which are an effective tool in the modelling of the decision-making in uncertain dynamic environments. Coordination between agents occurs through communication governed by an ant colony model.
Competitive advantage through safety compliance : smaller firm responses to changes in the Australian occupational health and safety regulatory context

Smaller firms are often viewed as resistant to regulation due to cost burdens. However, evidence indicates that for some compliance is beneficial under certain conditions. Drawing on data on attitudes and responses of smaller firm owner-managers to changes in Australia’s harmonising work health and safety context we report on smaller firms’ responses to these changes. Despite uncertainty due to incomplete harmonisation, many owner-managers viewed safety compliance as important and necessary to do business. Those with negative views still linked positive safety performance to business outcomes. We categorise smaller firms’ responses and in this sample most are Positive Responders. We suggest ways forward for policy-makers to support smaller firms in complying with occupational health and safety regulation.
Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal.

BACKGROUND & AIMS Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. METHODS Dual gastric and esophageal pH tracings were analyzed from 40 dyspeptic patients. Dual pH electrode pull-through studies were performed in healthy volunteers to document regional variation in intragastric pH under both fasting and postprandial conditions. The squamocolumnar junction was identified using radio-opaque endoscopic clips. We also examined in vitro partitioning of gastric juice added to a homogenized fatty meal. RESULTS The dual pH traces confirmed that esophageal refluxate was frequently more acidic than the body of the stomach after meals but not during fasting. The pull-through studies showed a pocket of acid at the gastroesophageal junction that escaped the buffering effect of meals, remaining highly acidic (median pH 1.6) compared with the body of the stomach (pH 4.7; P < 0.001). This proximal acid pocket extended from the cardia across the squamocolumnar junction 1.8 cm into the distal esophagus. The in vitro studies showed that acidic gastric juice could partition on top of a homogenized fatty meal. CONCLUSIONS After eating, highly acidic unbuffered gastric juice is present at the gastroesophageal squamocolumnar junction and is likely to contribute to the high prevalence of disease at this site.
Obniżenie kosztów za pomocą transakcji internetowych. Przykład Carrier Corporation

1. Koszty transakcyjne jako istotny element dzia3alnoci gospodarczej Koszty transakcyjne s1 obok kosztów produkcji  istotnym sk3adnikiem kosztów dzia3alnoci przedsiêbiorstwa. Zgodnie z teori1 kosztów transakcyjnych nale¿y zatem braæ pod uwagê sumê kosztów transakcyjnych i produkcji [Williamson, 1998, s. 35]. Pocz1tki tej teorii s1 zwi1zane z artyku3em póniejszego laureata Nagrody Nobla w dziedzinie ekonomii, Ronalda Coasea  TheNature of the Firm. Postawi3 onw nim tezê, i¿ organizacje i rynki stanowi1 alternatywne formy koordynacji dzia3alnoci gospodarczej (alokacji zasobów), a o wyborze jednej z nich decyduj1 ni¿sze koszty transakcyjne [Coase, 1937]. Kolejnym ekonomist1, który mia3 znacz1cy wp3yw na rozwój teorii, by3 ekonomista instytucjonalny John Commons. Wysun13 on postulat, i¿ transakcja powinna byæ uznana za podstawow1 jednostkê analizy ekonomicznej, co wskaza3o pole badawcze na znacznie ni¿szym poziomie analizy [za: Williamson, 1998, s. 17]. Idea Coasea zosta3a podjêta i rozwiniêta przez Olivera Williamsona prawie 40 lat póniej. Uzna3 on jednak¿e, i¿ rynki i hierarchie s1 tylko skrajnymi formami, miêdzy którymi mo¿na znaleæ wiele ró¿nych form porednich (hybrydowych), np. franchising [Williamson, 1991]. Victor Goldberg [1980] równie¿ zauwa¿y3, i¿ znaczna czêæ dzia3alnoci gospodarczej opiera siê na d3ugotrwa3ych, skomplikowanych, czasem wielostronnych relacjach kontraktowych (lub podobnych). Strony takich kontraktów dzia3aj1 wwarunkach ograniczonej informacji, której nabycie wi1¿e siê zawsze z pewnymi kosztami, s1 sk3onne do wykorzystania nadarzaj1cych siê okazji kosztem partnera (zachowania oportunistyczne) oraz nie maj1 do dyspozycji taniego zewnêtrznego mechanizmu egzekwowania wykonania umowy. Williamson wymieni3 trzy podstawowe wymiary transakcji, które decyduj1 o ró¿nicach w poziomie kosztów transakcyjnych: specyficznoæ aktywów, niepewnoæ dotycz1ca zachowañ oraz czêstotliwoæ zawierania transakcji [Williamson, 1979, 1989, 1995 1996a i 1998]. Najwa¿niejszym czynnikiem ró¿nicuj1cym transakcje jest wed3ug niego specyficznoæ aktywów. Charakterystyczn1 cech1 specyficznych aktywów jest ich ograniczona przenonoæ do in-
Distinct Golgi Populations of Phosphatidylinositol 4-Phosphate Regulated by Phosphatidylinositol 4-Kinases*

Phosphatidylinositol 4-phosphate (PI4P) regulates biosynthetic membrane traffic at multiple steps and differentially affects the surface delivery of apically and basolaterally destined proteins in polarized cells. Two phosphatidylinositol 4-kinases (PI4Ks) have been localized to the Golgi complex in mammalian cells, type III PI4Kβ (PI4KIIIβ) and type II PI4Kα (PI4KIIα). Here we report that PI4KIIIβ and PI4KIIα localize to discrete subcompartments of the Golgi complex in Madin-Darby canine kidney (MDCK) cells. PI4KIIIβ was enriched in early Golgi compartments, whereas PI4KIIα colocalized with markers of the trans-Golgi network (TGN). To understand the temporal and spatial control of PI4P generation across the Golgi complex, we quantitated the steady state distribution of a fluorescent PI4P-binding domain relative to cis/medial Golgi and TGN markers in transiently transfected MDCK cells. The density of the signal from this PI4P reporter was roughly 2-fold greater in the early Golgi compartments compared with that of the TGN. Furthermore, this ratio could be modulated in vivo by overexpression of catalytically inactive PI4KIIIβ and PI4KIIα or in vitro by the PI4KIIIβ inhibitor wortmannin. Our data suggest that both PI4KIIIβ and PI4KIIα contribute to the compartmental regulation of PI4P synthesis within the Golgi complex. We discuss our results with respect to the kinetic effects of modulating PI4K activity on polarized biosynthetic traffic in MDCK cells.
Does living in remote Australia lessen the impact of hardship on psychological distress?

Aims. Rural and remote regions tend to be characterised by poorer socioeconomic conditions than urban areas, yet findings regarding differences in mental health between rural and urban areas have been inconsistent. This suggests that other features of these areas may reduce the impact of hardship on mental health. Little research has explored the relationship of financial hardship or deprivation with mental health across geographical areas. Methods. Data were analysed from a large longitudinal Australian study of the mental health of individuals living in regional and remote communities. Financial hardship was measured using items from previous Australian national population research, along with measures of psychological distress (Kessler-10), social networks/support and community characteristics/locality, including rurality/remoteness (inner regional; outer regional; remote/very remote). Multilevel logistic regression modelling was used to examine the relationship between hardship, locality and distress. Supplementary analysis was undertaken using Australian Household, Income and Labour Dynamics in Australia (HILDA) Survey data. Results. 2161 respondents from the Australian Rural Mental Health Study (1879 households) completed a baseline survey with 26% from remote or very remote regions. A significant association was detected between the number of hardship items and psychological distress in regional areas. Living in a remote location was associated with a lower number of hardships, lower risk of any hardship and lower risk of reporting three of the seven individual hardship items. Increasing hardship was associated with no change in distress for those living in remote areas. Respondents from remote areas were more likely to report seeking help from welfare organisations than regional residents. Findings were confirmed with sensitivity tests, including replication with HILDA data, the use of alternative measures of socioeconomic circumstances and the application of different analytic methods. Conclusions. Using a conventional and nationally used measure of financial hardship, people residing in the most remote regions reported fewer hardships than other rural residents. In contrast to other rural residents, and national population data, there was no association between such hardship and mental health among residents in remote areas. The findings suggest the need to reconsider the experience of financial hardship across localities and possible protective factors within remote regions that may mitigate the psychological impact of such hardship.