Miracle-dz/UniFAR-FTUs huggingface dataset:
A Hybrid Approach to Sentiment Analysis of Technical Article Reviews

Sentiment analysis is similar to opinion mining, which is a popular research problem to search out in the field of NLP. Sentiment analysis determines the perspective of the author and identifies the positive, negative and neutral reviews. It provides the reviews or opinions of people‟s on text, article and product which can be positive, negative or neutral. Reviews on the different websites, social networking sites is an important source to collect the information regarding various brands of product and new features in technology (e.g. Windows, Mobiles). During the sentiment analysis various classification tools within the NLP are used to find out the positivity and negativity of reviews or comments. The paper presents a length aware hybrid approach to analyses the reviews either as positive or negative and present approach is tested on SuperFetch data set. The present approach is a combination of both supervised machine learning techniques that are Support Vector Machine and K-Nearest Neighbor in which SVM is working great for large size review and KNN is working best for small size review.
Regulation of human histone gene expression: transcriptional and posttranscriptional control in the coupling of histone messenger RNA stability with DNA replication.

The extent to which transcriptional and posttranscriptional regulation contributes to the coupling of histone gene expression and DNA replication was examined during the cell cycle in synchronized HeLa S3 cells. Rates of transcription were determined in vitro in isolated nuclei. A 3-5-fold increase in cell cycle dependent histone gene transcription was observed in early S phase, prior to the peak of DNA synthesis. This result is consistent with a previous determination of histone mRNA synthesis in intact cells [Plumb, M. , Stein, J., & Stein, G. (1983) Nucleic Acids Res. 11, 2391]. The transcription of these genes did not change appreciably after inhibition of DNA replication by hydroxyurea treatment, although Northern blot analysis indicated that cellular levels of histone mRNA decreased rapidly in the presence of the drug. Total cellular levels of histone mRNA closely parallel the rate of DNA synthesis as a function of cell cycle progression, reaching a maximal 20-fold increase as compared with non S phase levels. This DNA synthesis dependent accumulation of histone mRNA occurs predominantly in the cytoplasm and appears to be mediated primarily by control of histone mRNA stability. Changes in nuclear histone mRNA levels were less pronounced. These combined observations suggest that both transcriptional regulation and posttranscriptional regulation contribute toward control of the cell cycle dependent accumulation of histone mRNA during S phase, while the stability of histone mRNA throughout S phase and the selective turnover of histone mRNAs, either at the natural termination of S phase or following inhibition of DNA synthesis, are posttranscriptionally regulated. (ABSTRACT TRUNCATED AT 250 WORDS)
Reproduction of Cultural Values

Narratives are one of the oldest and universal forms of communication in human societies. In the present research, the authors hypothesized that narratives play an important role in the reproduction of cultural values. To test this idea, Study 1 examined the contents of stories created by American and Japanese participants for their reflection of individualistic and collectivistic values, and Study 2 examined whether information consistent with cultural values would be more likely to be retained and passed onto others. The studies found that American participants created stories that reflected individualistic values and retained more individualistic information than collectivistic information when they transmitted a story to others. In contrast, Japanese participants created stories that reflected collectivistic values and retained more collectivistic information than individualistic information when they transmitted a story to others. These findings support the idea that narrative communication is an important part of cultural reproduction mechanism.
Effect of dantrolene premedication on various cardiovascular and biochemical variables and the recovery in healthy isoflurane-anesthetized horses.

OBJECTIVE To determine the effect of dantrolene premedication on various cardiovascular and biochemical variables and recovery in isoflurane-anesthetized horses. ANIMALS 6 healthy horses. PROCEDURES Each horse was anesthetized twice with a 21- to 28-day washout period between anesthetic sessions. Food was not withheld from horses before either session. During each session, dantrolene (6 mg/kg in 2 L of water) or water (2 L) was administered via a nasogastric tube 1 hour before anesthesia was induced. Anesthesia was maintained with isoflurane for 90 minutes, during which blood gas analyses and lithium-dilution cardiac output (CO) measurements were obtained every 10 minutes. Serum creatine kinase activity was measured before and at 4, 8, and 12 hours after anesthesia. RESULTS When horses were premedicated with dantrolene, CO at 25, 35, and 45 minutes after induction of anesthesia was significantly lower than that when horses were premedicated with water after which time difficulty in obtaining valid measurements suggested a continued decrease in CO; plasma potassium concentration progressively increased during anesthesia, whereas serum creatine kinase activity remained fairly stable and within reference limits through 12 hours after anesthesia; and 2 of 6 horses developed cardiac arrhythmias that required medical intervention. The quality of anesthetic recovery was slightly better when horses were premedicated with dantrolene versus water, although the time required for recovery did not differ significantly between treatments. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that dantrolene premedication prevented muscle damage without affecting anesthetic recovery but impaired CO and precipitated hyperkalemia and cardiac arrhythmias in healthy isoflurane-anesthetized horses.
Hospital admissions of asthmatics bv age and sex

Asthma‐related hospital admissions and the occurrence of new admissions were studied by age and sex in order to find the groups of asthmatics with high hospital admission rates. Data from the Finnish discharge register for 1972–92 were used to analyze the number of hospital admissions caused by asthma (defined in the International Clussification of Diseases, 8th and 9th revisions, code 493) and occurrence of new asthma admissions between 1983 and 1992. A total of 192195 asthma‐induced treatment periods were identified, 91 223 for males and 100972 for females. Boys were admitted twice as often as girls at the age of 1 year (11.2 in comparison with 5.9 admissions per 1000 per year), whereas the admission rate was consistently higher among women 25–55 years of age. The highest asthma admission rate among the elderly was at age 73 for men (10.3 per 1000) and 75 for women (9.5 per 1000). Occurrences of new asthma admissions were most frequent at the age of 1 year (5.3 per 1000 for boys and 2.9 per 1000 for girls) and remained constant among those aged 50–80 years. Asthma is not only a disease of childhood and adolescence. The number of middle‐aged and elderly asthmatics requiring hospitalization is markedly high.
Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages

Lentiviruses, which cause arthritis-encephalitis and maedi-visna in goats and sheep, respectively, cause persistent infections in these animals. The viruses replicate productively at low levels in macrophages in diseased organs such as the "maedi lung" and nonproductively in other cell types such as leukocytes in peripheral blood. Nonproductive infections become productive during in vitro cultivation of the cells. This study showed that monocytes were the only cells in the peripheral blood leukocytes of an infected animal in which virus was detected and that virus activation occurred only when these cells matured into macrophages. Only a minute fraction of cultured monocytes matured into macrophages, and viral infectivity was associated exclusively with this fraction. Antiglobulin-coated glass wool fragments were lethal for monocyte macrophages because of toxic phagocytosis, but had no effect on B or T lymphocytes. The simultaneous addition of the glass fragments and leukocytes to culture dishes resulted in no macrophage maturation and no virus production. The addition of the fragments to virus-producing macrophages caused the death of the cells and a decline in virus production. Virus production in less avidly phagocytic cells was unaffected by the glass. Thus, although macrophages may be permissive for virus replication, one mechanism for restricted virus expression in vivo may be physiological factors controlling the maturation of these cells.
Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis.

This is the second in a series of four articles Studies that show a significant effect of treatment are more likely to be published, be published in English, be cited by other authors, and produce multiple publications than other studies.1–8 Such studies are therefore also more likely to be identified and included in systematic reviews, which may introduce bias.9 Low methodological quality of studies included in a systematic review is another important source of bias.10 All these biases are more likely to affect small studies than large ones. The smaller a study the larger the treatment effect necessary for the results to be significant. The greater investment of time and money in larger studies means that they are more likely to be of high methodological quality and published even if their results are negative. Bias in a systematic review may therefore become evident through an association between the size of the treatment effect and study size—such associations may be examined both graphically and statistically. #### Summary points Asymmetrical funnel plots may indicate publication bias or be due to exaggeration of treatment effects in small studies of low quality Bias is not the only explanation for funnel plot asymmetry; funnel plots should be seen as a means of examining “small study effects” (the tendency for the smaller studies in a meta-analysis to show larger treatment effects) rather than a tool for diagnosing specific types of bias Statistical methods may be used to examine the evidence for bias and to examine the robustness of the conclusions of the meta-analysis in sensitivity analyses “Correction” of treatment effect estimates for bias should be avoided as such corrections may depend heavily on the assumptions made Multivariable models may be used, with caution, to examine the relative importance of different types of bias ### Funnel plots Funnel …
Generation of Orthogonally Polarized Mode-Locked Lasers at Wavelength of 1342 nm

A mode-locked laser with orthogonal polarization at the wavelength of 1342 nm is experimentally achieved by using the natural birefringence of the Nd:YVO4 crystal. A total output power of 2.64 W could be obtained at an incident power of 14.4 W and the pulse durations are measured to be 15.1 and 16.9 ps with pulse repetition rates of 6.0 and 6.45 GHz for the laser output along the π- and σ-polarization, respectively. The mode-locked output is further found to exhibit a complex temporal trace with beat frequencies originated from the different central frequencies and pulse repetition rates.
Quality Control Pathways for Nucleus-Encoded Eukaryotic tRNA Biosynthesis and Subcellular Trafficking

ABSTRACT tRNAs perform an essential role in translating the genetic code. They are long-lived RNAs that are generated via numerous posttranscriptional steps. Eukaryotic cells have evolved numerous layers of quality control mechanisms to ensure that the tRNAs are appropriately structured, processed, and modified. We describe the known tRNA quality control processes that check tRNAs and correct or destroy aberrant tRNAs. These mechanisms employ two types of exonucleases, CCA end addition, tRNA nuclear aminoacylation, and tRNA subcellular traffic. We arrange these processes in order of the steps that occur from generation of precursor tRNAs by RNA polymerase (Pol) III transcription to end maturation and modification in the nucleus to splicing and additional modifications in the cytoplasm. Finally, we discuss the tRNA retrograde pathway, which allows tRNA reimport into the nucleus for degradation or repair.
Tracking gene expression during zebrafish osteoblast differentiation

The transcription factors RUNX2 and OSX have been shown to act sequentially to direct mammalian osteoblast differentiation. RUNX2 is required during the early stages of commitment and acts in part to activate Osx transcription. OSX and RUNX2 then act to direct transcription of bone matrix proteins. Here, we investigate the expression of these genes and others during zebrafish osteoblastogenesis. Using whole‐mount in situ hybridization, we find that, during the formation of a given bone, the zebrafish homologues of mouse Runx2 (runx2a and runx2b) are typically expressed before the onset of osx. osx expression is usually followed by up‐regulation of the bone matrix proteins, col1a2 and osteonectin. These results suggest that the mammalian pathway is conserved during development of the head and shoulder skeleton of zebrafish. We also analyze the expression of three atypical bone markers (tcf7, cvl2, and col10a1) in an effort to place them within this canonical hierarchy. Developmental Dynamics 238:459–466, 2009. © 2009 Wiley‐Liss, Inc.
Development of a rural health framework: implications for program service planning and delivery.

PURPOSE To describe the development and application of an evidence-based rural health framework to guide rural health program, policy and service planning. METHODS A literature review of rural health programs, focusing on health promotion, chronic disease prevention and population health, was conducted using several bibliographic databases. FINDINGS Thirty papers met the criteria for review, describing chronic disease interventions and public health policies in rural settings. Twenty-one papers demonstrated effective intervention programs and highlighted potential good practices for rural health programs, which were used to define key elements of a rural health framework. CONCLUSIONS The rural health framework was applied to an influenza immunization program to demonstrate its utility in assisting public health providers to increase uptake of the vaccine. This rural health framework provides an opportunity for program planners to reflect on the key issues facing rural communities to ensure the development of policies and strategies that will prudently and effectively meet population health needs.
An Open Framework for Participatory PM2.5 Monitoring in Smart Cities

As the population in cities continues to increase rapidly, air pollution becomes a serious issue from public health to social economy. Among all pollutants, fine particulate matters (PM2.5) directly related to various serious health concerns, e.g., lung cancer, premature death, asthma, and cardiovascular and respiratory diseases. To enhance the quality of urban living, sensors are deployed to create smart cities. In this paper, we present a participatory urban sensing framework for PM2.5 monitoring with more than 2500 devices deployed in Taiwan and 29 other countries. It is one of the largest deployment project for PM2.5 monitor in the world as we know until May 2017. The key feature of the framework is its open system architecture, which is based on the principles of open hardware, open source software, and open data. To facilitate the deployment of the framework, we investigate the accuracy issue of low-cost particle sensors with a comprehensive set of comparison evaluations to identify the most reliable sensor. By working closely with government authorities, industry partners, and maker communities, we can construct an effective eco-system for participatory urban sensing of PM2.5 particles. Based on our deployment achievements to date, we provide a number of data services to improve environmental awareness, trigger on-demand responses, and assist future government policymaking. The proposed framework is highly scalable and sustainable with the potential to facilitate the Internet of Things, smart cities, and citizen science in the future.
Sympathetic tone in the young: the mother weighs in.

The increasingly recognized notion that conditions during fetal life alter susceptibility to adult disease represents a prototype of how the environment can influence biological processes. Several conditions, including stress exposure, maternal nutrition, and environmental temperature, have been shown to affect the health of offspring. The fast-growing epidemic of obesity has witnessed mounting interest in the effect of maternal obesity on disease development in the offspring. In humans, epidemiological observations consistently noted the close relationship between maternal obesity and increased adiposity in the offspring. Offspring born to overweight or obese mothers were found to be at higher risk of developing greater weight gain or obesity during childhood, adolescence, or adulthood, suggesting that these disorders may have a developmental origin.1,2 These studies also raised the possibility of neonatal origins of the diseases commonly associated with obesity, including hypertension. Prospective cohort studies have demonstrated that maternal obesity promotes higher blood pressure in the offspring. Systolic blood pressure in the offspring was found to be, on average, 0.2 mm Hg higher for each 0.1 kg of excessive weight gained by the mother during the pregnancy.2 A causal relationship between exposure to obesity in the perinatal period and increased adiposity in the offspring may contribute to the current epidemic of obesity through a continuous intergenerational cycle (Figure). Figure. Schematic representation of the mechanisms involved in fetal programming of obesity and hypertension. Excessive weight gain and obesity during pregnancy program selectivity in leptin resistance in the offspring: loss of metabolic action of leptin promotes obesity, whereas preservation of sympathetic nerve activation to leptin causes higher sympathetic tone leading to hypertension. The developmental origin of excess weight gain and adiposity may contribute to …
Loss analysis of permanent-magnet motor considering carrier harmonics of PWM inverter using combination of 2-D and 3-D finite-element method

In this paper, we propose a novel method to calculate harmonic losses of permanent-magnet motors driven by pulsewidth modulation inverters. First, two-dimensional (2-D) nonlinear time-domain finite-element analysis is applied to estimate the harmonic rotational magnetic field at the air gap of the motor. Next, the three-dimensional frequency domain finite-element analyses at each remarkable harmonic field are carried out with the results of the harmonic gap flux densities obtained by the 2-D analysis. Using this procedure, the magnet eddy-current loss caused by the carrier harmonics of the inverter can be calculated with practical computer resources.
The metabolic syndrome: more than the sum of its components?

See related article, pages 1078–1083. The metabolic syndrome is a clustering of metabolic abnormalities, which include insulin resistance or diabetes, obesity, hypertension, and dyslipidemia. Although the mechanisms of the underlying abnormalities remain to be clarified, the pathogenesis includes both genetic predisposition and modifiable risk factors such as sedentary lifestyle and dietary intake. Recent estimates suggest that approximately 24% of US adults have the metabolic syndrome.1 In several studies, the metabolic syndrome has been shown to increase the risk of cardiovascular diseases2; however, the strength of its association with stroke is weaker than that for coronary heart disease.3 In the guidelines for the primary prevention of stroke from the American Heart Association/American Stroke Association, the metabolic syndrome is listed as a less–well-documented risk factor.4 But, given the high prevalence of the metabolic syndrome, studying its association with stroke is certainly relevant for 2 reasons: first, to obtain a better etiologic understanding of the causes of stroke; second, to identify individuals at high risk for stroke. This translates into 2 distinct scientific questions: is the metabolic syndrome by itself a risk factor for stroke? ; and can we predict which individuals are at increased risk for stroke based on information about the metabolic syndrome? To answer these questions from observational data, one needs 2 distinct model-building strategies that require differences in assumptions of biological associations and statistical considerations.5,6 In this issue of Stroke ,7 Wang and …
A three-port half-bridge converter with synchronous rectification for renewable energy application

A three-port half-bridge converter for stand-alone renewable power system is proposed. The converter, featuring one input port, one bidirectional port and one isolated output port, is derived by integrating half-bridge, forward-flyback and Buck topologies. The magnetizing inductor of the transformer functions as an inductor, by which a power flow path can be configured between the renewable source and the battery, and the synchronous rectification circuit provides a free-wheeling path for the current of inductor-transformer. The power flow through the three ports is controlled with the two switches in primary operating independently. Single stage power conversion between any two of the three ports is achieved. The operational states and principles of the proposed converter are analyzed in detail and verified with experimental results. Furthermore, the topology generation and control method of the proposed three-port half-bridge converter is extended and some other novel three-port and multi-port half-bridge converter topologies are proposed.
Proteomic and transcriptomic analysis for streptozotocin‐induced diabetic rat pancreas in response to fungal polysaccharide treatments

In an attempt to search for novel biomarkers for monitoring diabetes prognosis, we examined the influence of the hypoglycemic fungal extracellular polysaccharides (EPS) on the differential change in pancreatic proteome and transcriptome in streptozotocin (STZ)‐induced diabetic rats using 2‐DE‐based protein mapping and oligonucleotide microarray analysis. The 2‐DE system separated more than 2000 individual spots, demonstrating that 34 proteins out of about 500 matched spots were differentially expressed. A total of 22 overexpressed and 12 underexpressed proteins in 2‐DE map were observed (p<0.05) between the healthy and diabetic rats, of which 26 spots were identified by PMF analysis. Of these, significant down regulation of carbonyl reductase (Cbr), hydroxymethylglutaryl‐CoA synthase (HMGCS), and putative human mitogen‐activated protein kinase activator with WD repeats‐binding protein (MAWDBP) in diabetic pancreas were reported for the first time in this study. When treated with EPS, all these four proteins were reverted to normal levels. The microarray analysis revealed that 96 out of 1272 genes were down‐ or up‐regulated in the diabetic rats and the altered transcript levels of many of these genes were reversed after EPS treatment. In particular, ROS generation in rat islets was significantly increased after STZ treatment, thereafter EPS treatment was likely to play a preventive role in β‐cell destruction mediated by STZ. Taken together, EPS may act as a potent regulator of gene expression for a wide variety of genes in diabetic rats, particularly in antioxidative stress, insulin biosynthesis, and cell proliferation.