Miracle-dz/UniFAR-FTUs huggingface dataset:
Chronic Hepatitis B Infection: Long Term Comparison of Children Receiving Interferon Alpha and Untreated Controls

Objectives: To investigate the virological outcome of chronic hepatitis B (CH-B) in children who received interferon alpha (IFN) compared with no treatment. Methods: Seventy-four children with CH-B (median age, 6.1 years; 44 boys) selected from a cohort of 158 cases were included and divided into two groups: IFN-treated (n = 37) and control (n = 37). The controls were matched with the treated children by baseline alanine aminotransferase (ALT) levels, sex and age. The Kaplan-Meier method was performed to estimate the time to clearance of hepatitis B e antigen (HbeAg) and hepatitis B surface antigen (HbsAg). Results: Mean duration of follow-up was comparable in two groups (5.2 ± 3.8 years in treatment group versus 5.2 ± 3.7 years in control group, NS). HBeAg and HBsAg loss occurred in 20 (54.1%) and three treated children versus 13 (35.1%) and one untreated children (NS), respectively. The 7-year cumulative HBeAg and HBsAg clearance rates were 47.5% and 8.9% after the first visit in the treatment group versus 33.5% and 4.0% in untreated children (NS), respectively. Elevated baseline ALT (two times upper limit of normal) had a significant effect on the long-term cumulative rate of HBeAg seroconversion in treated patients (P = 0.01) but not in the untreated group. Conclusions: These findings show that the overall long-term virological outcome does not differ significantly between IFN-treated and untreated children but that a significant benefit of treatment on the long term rate of HBeAg seroconversion is obtained in children with higher baseline ALT levels.
Investigation of the properties and potential medical applications of natural silk fibers produced by Eupackardia calleta

Silk has been considered biocompatible and used for medical applications for centuries. However, most of the silk currently used is produced by the domesticated silkworm, Bombyx mori. Recently, it has been demonstrated that silk produced by saturniidae insects such as Antheraea mylitta, Phylisomia ricini, and Antheraea pernyi had unique properties and suitable for medical applications. Therefore, efforts are being made to identify and study the structure and properties of silks produced by wild insects (non B. mori), spiders, and ants to understand their suitability for various medical applications. Eupackardia calleta belongs to the Saturniidae family of insects, but the structure, properties, and potential medical uses of silk fibers produced by E. calleta are not known. In this research, we have characterized the properties of silk fibers produced by E. calleta and the ability of the fibers to support the attachment and proliferation of mouse fibroblast cells. Silk produced by E. calleta had considerably different amino acid composition than B. mori and A. mylitta, P. ricini, and A. pernyi silks. Breaking tenacity of the E. calleta silk fibers at 400 MPa was between that of B. mori silk and A. mylitta, P. ricini, and A. pernyi silks. E. calleta showed good attachment and spreading of mouse fibroblast cells suggesting potential for medical applications.
A Comparison of Two Smoothing Methods for Word Bigram Models

A COMPARISON OF TWO SMOOTHING METHODS FOR WORD BIGRAM MODELS Linda Bauman Peto Department of Computer Science University of Toronto Abstract Word bigram models estimated from text corpora require smoothing methods to estimate the probabilities of unseen bigrams. The deleted estimation method uses the formula: Pr(i|j) = lambda f_i + (1-lambda)f_i|j, where f_i and f_i|j are the relative frequency of i and the conditional relative frequency of i given j, respectively, and lambda is an optimized parameter. MacKay (1994) proposes a Bayesian approach using Dirichlet priors, which yields a different formula: Pr(i|j) = (alpha/F_j + alpha) m_i + (1 - alpha/F_j + alpha) f_i|j where F_j is the count of j and alpha and m_i are optimized parameters. This thesis describes an experiment in which the two methods were trained on a two-million-word corpus taken from the Canadian _Hansard_ and compared on the basis of the experimental perplexity that they assigned to a shared test corpus. The methods proved to be about equally accurate, with MacKay's method using fewer resources.
Normative health-related fitness values for children: analysis of 85347 test results on 9–17-year-old Australians since 1985

Objectives To provide sex- and age-specific normative values for health-related fitness of 9–17-year-old Australians. Methods A systematic literature search was undertaken to identify peer-reviewed studies reporting health-related fitness data on Australian children since 1985—the year of the last national fitness survey. Only data on reasonably representative s amples of apparently healthy (free from known disease or injury) 9–17-year-old Australians, who were tested using field tests of health-related fitness, were included. Both raw and pseudo data (generated using Monte Carlo simulation) were combined with sex- and age-specific normative centile values generated using the Lambda Mu and Sigma (LMS) method. Sex- and age-related differences were expressed as standardised effect sizes. Results Normative values were displayed as tabulated percentiles and as smoothed centile curves for nine health-related fitness tests based on a dataset comprising 85347 test performances. Boys typically scored higher than girls on cardiovascular endurance, muscular strength, muscular endurance, speed and power tests, but lower on the flexibility test. The magnitude of the age-related changes was generally larger for boys than for girls, especially during the teenage years. Conclusion This study provides the most up-to-date sex- and age-specific normative centile values for the health-related fitness of Australian children that can be used as benchmark values for health and fitness screening and surveillance systems.
GREEN - - A Multi-Region Dynamic General Equilibrium Model for Quantifying the Costs of Curbing CO2 Emissions

The OECD Secretariat has developed a multi-region, multi-sector, dynamic applied general equilibrium (AGE) model to quantify the economy-wide and global costs of policies to curb emissions of carbon dioxide (CO2). The project is called the GeneRal Equilibrium ENvironments model, hereafter referred to as GREEN. The purpose of this paper is to provide a full technical description of the GREEN model, its data base and parametrisation as of May 1991. Work is continuing to extend GREEN in several different directions to make the model more policy relevant, and a revised version of the technical manual will be issued in due course .
Do Public Corruption Convictions Influence Citizens’ Trust in Government? The Answer Might Not Be a Simple Yes or No

The influence of corruption convictions on government trust is complicated. On one hand, they may reflect the severity of corruption in a jurisdiction. On the other hand, they might indicate the degree of anticorruption efforts. Existing literature has suggested the severity of corruption’s negative effects and the positive effect of anticorruption efforts on institutional trust. This research synthesized existing studies, identified the intellectual puzzle in the literature, and developed open hypotheses to investigate the way in which corruption convictions systematically affect citizens’ trust in government. State-level panel data merged from different sources were used for the empirical analyses. The results showed a positive influence of corruption convictions on public trust in government.
Change in tobacco use among 13-15 year olds between 1999 and 2008: Findings from the Global Youth Tobacco Survey

Tobacco use is the leading preventable cause of death and disease in the world; yet little is known about the levels or patterns of youth tobacco use on a global basis. The purpose of this paper is to focus on change in youth tobacco use using data from 100 sites that have conducted repeat Global Youth Tobacco Surveys (GYTS). The GYTS is a school-based survey that collects data from students aged 13–15 years using a standardized methodology for constructing the sample frame, selecting schools and classes, and processing data. GYTS is conducted in school classes using self-administered anonymous data collection. The GYTS sample produces representative, independent, cross-sectional estimates for each sampling frame. Of the 100 sites surveyed, 61 reported no change over time in prevalence of cigarette smoking, likewise in 50 of the 97 sites with data on use of other tobacco products there was no change. However, 34 sites reported an increase in other tobacco use. This appears to be attributed to waterpipe, an emerging trend in tobacco use. Evidence was found supporting the idea that tobacco use among adolescent girls is likely increasing. The global tobacco control effort continues to face many challenges in reversing the tobacco epidemic. Few countries have implemented comprehensive tobacco control legislation laid out by the World Health Organization. The few countries that have adopted some of these proven policies can serve as examples in achieving positive results in curbing the tobacco epidemic. (Global Health Promotion, 2009; Supp (2): pp. 38–90)
Effect of Electroconvulsive Therapy on the Electrocardiogram and Echocardiogram

Although electrocardiographic (ECG) ST segment depression is commonly induced by electroconvulsive therapy (ECT) for depression, it is unknown whether this reflects segmental myocardial ischemia, as is true under most circumstances, or a direct effect of central nervous system stimulation on cardiac repolarization in the absence of ischemic left ventricular regional wall motion abnormalities. We evaluated the association between ECG changes and left ventricular regional wall motion abnormalities detected by the echocardiograms performed before and after ECT in 11 patients. Immediately after ECT, three patients' ECGs revealed 1-mm downsloping or horizontal ST segment depression, one had a nonspecific ECG change (peaked T waves), and the ECG remained normal in seven. All patients had normal baseline echocardiograms. After ECT, at a time when the product of arterial blood pressure and heart rate was 100% above baseline values, five patients developed new left ventricular regional wall motion abnormalities that were confined to hypokinesia; no patient developed myocardial infarction or angina after ECT. Three patients with regional wall motion abnormalities developed ECG ST segment depression after ECT (sensitivity 60%), one had a nonspecific ECG change (peaked T waves), and the ECG of one patient remained normal. In conclusion, ECT may induce ECG changes with simultaneous regional wall motion abnormalities at a time when arterial blood pressure and heart rate are markedly elevated, findings that are highly suggestive of “demand” myocardial ischemia. In this small series, ECG or echocardiographic abnormalities did not predict clinical cardiac morbidity.
Identification of Drought in Western Slovakia by Palmer Drought Severity Index (PDSI)

Abstract The paper deals with identification of drought in western Slovakia, which is based on soil-climatological data. For this purpose, three sites were chosen: Bratislava, Piešťany and Hurbanovo, situated on the Danubian Lowland. The Palmer Drought Severity Index (PDSI) was calculated on monthly basis for time series 1981–2010, 2021–2050 and 2071–2100. There were determined the driest periods by percentage of dry months for each site. The driest period in Bratislava and Hurbanovo was in the first evaluated time series. In Piešťany we can expect, that the second time series will be the driest. Linear trend of drying area will be revealed in period 2071–2100 for all three sites. The aim of the paper is to analyze and compare the occurrence of drought in temporal and spatial dimensions on the west part of Slovakia.
In vitro activity and beta-lactamase stability of a new difluoro oxacephem, 6315-S

6315-S, a novel difluoromethyl thioacetamido oxacephem, had in vitro activity comparable to that of cefotaxime and moxalactam against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Klebsiella oxytoca, Citrobacter diversus, Salmonella spp. , and Shigella spp. , inhibiting 90% at less than or equal to 0.25 microgram/ml. It inhibited piperacillin- and cefoperazone-resistant isolates in these species. 6315-S did not inhibit cefotaxime- or moxalactam-resistant Citrobacter freundii, Enterobacter aerogenes, or Enterobacter cloacae (MICs for 90% of the strains tested were greater than or equal to 16 micrograms/ml). Proteus vulgaris resistant to cefotaxime was inhibited. Pseudomonas species and Acinetobacter species were resistant (MICs greater than 64 micrograms/ml). MICs for 90% of the Staphylococcus aureus and S. epidermidis isolates were 4 micrograms/ml. 6315-S was highly active against anaerobic species of Clostridium, Fusobacterium, Bacteroides, and peptostreptococci and was superior to other agents against these organisms. 6315-S was not hydrolyzed by the major plasmid and chromosomal beta-lactamases, but it induced chromosomal beta-lactamases in Enterobacter cloacae and Pseudomonas aeruginosa.
Nursing home placement, day care use, and cognitive decline in Alzheimer's disease.

OBJECTIVE People with Alzheimer's disease are often placed in a nursing home, sometimes after using adult day care services. How affected persons function during this potentially difficult transition is not well understood. The aim of this study was to examine the associations of day care use and nursing home placement with the rate of cognitive decline in Alzheimer's disease. METHOD The participants were 432 older persons with Alzheimer's disease who were recruited from health care settings in the Chicago area. At baseline, they lived in the community and were using day care services a mean 1.7 days per week. At 6-month intervals for up to 4 years, they completed nine cognitive tests from which a composite measure of global cognition was derived. RESULTS On average, cognition declined at a gradually increasing rate during the study period. Nursing home placement was associated with a decrease in the level of cognition and an acceleration in the rate of cognitive decline. Day care use at baseline was not related to cognitive decline in initial analyses, but it interacted with nursing home placement such that higher level of day care use substantially reduced association of placement with accelerated cognitive decline. Education interacted with placement such that more schooling was associated with a greater increase in cognitive decline upon nursing home placement, but prior day care use also attenuated this association. CONCLUSIONS Nursing home placement is associated with accelerated short-term cognitive decline in Alzheimer's disease. Prior experience in adult day care may lessen this association.
Optimal Joint Remote Radio Head Selection and Beamforming Design for Limited Fronthaul C-RAN

This paper considers the downlink transmission of cloud-radio access networks (C-RANs) with limited fronthaul capacity. We formulate a joint design of remote radio head (RRH) selection, RRH-user association, and transmit beamforming for simultaneously optimizing the achievable sum rate and total power consumption, using the multiobjective optimization concept. Due to the nonconvexity of perfronthaul capacity constraints and introduced binary selection variables, the formulated problem lends itself to a mixed-integer nonconvex program, which is generally non-deterministic polynomial-time hard. Motivated by powerful computing capability of C-RAN and for benchmarking purposes, we propose a branch and reduce and bound-based algorithm to attain a globally optimal solution. For more practically appealing approaches, we then propose three iterative low-complexity algorithms. In the first method, we iteratively approximate the continuous nonconvex constraints by convex conic ones using successive convex approximation framework. More explicitly, the problem obtained at each iteration is a mixed-integer second-order cone program (MI-SOCP) for which dedicated solvers are available. In the second method, we first relax the binary variables to be continuous to arrive at a sequence of SOCPs and then perform a postprocessing procedure on the relaxed variables to search for a high-performance solution. In the third method, we solve the considered problem in view of sparsity-inducing regularization. Numerical results show that our proposed algorithms converge rapidly and achieve near-optimal performance as well as outperform the known algorithms.
Internalin B is essential for adhesion and mediates the invasion of Listeria monocytogenes into human endothelial cells

Listeria monocytogenes causes rhombencephalitis in humans and animals and also affects the fetus in utero, causing disseminated sepsis. In both instances, the infection occurs by the crossing of endothelial cells lining a physiological barrier, the blood–brain barrier or the transplacental barrier. In this study, the ability of L. monocytogenes wild‐type EGD to invade human umbilical vein endothelial cells (HUVECs) was evaluated using wild‐type bacteria and isogenic Listeria mutants. Here, we show that invasion of HUVECs by L. monocytogenes is dependent on the expression of the internalin B gene product. This was demonstrated in several ways. First, L. monocytogenes strains lacking the inlB gene did not invade HUVECs. Secondly, avid invasion was obtained when a strain deleted for inlAB was complemented with a plasmid harbouring inlB only, whereas strains expressing inlA did not enter HUVECs. Thirdly, entry of wild‐type EGD could be blocked effectively with antibodies to InlB. Fourthly, cell binding assays and flow cytometry with HUVECs showed binding of purified InlB, but not InlA, suggesting a tropism of InlB for this cell type. Finally, physical association of purified native InlB with the surface of non‐invasive mutants dramatically increased their ability to invade HUVECs. In laser‐scanning confocal microscopy, binding of InlB was observed as focal and localized patches on the cell surface of HUVECs. Qualitative examination of the entry process by scanning electron microscopy revealed that both wild‐type EGD and a recombinant strain overexpressing only InlB enter HUVECs in a similar fashion. The entry process was polarized, involved single bacteria and occurred over the entire surface of endothelial cells.
American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: cardiac and pulmonary late effects.

PURPOSE To review the evidence on the incidence of long-term cardiac or pulmonary toxicity secondary to chemotherapy, radiotherapy, or trastuzumab in symptomatic and asymptomatic cancer survivors. METHODS An American Society of Clinical Oncology Panel reviewed pertinent information from the literature through February 2006. RESULTS Few studies directly addressing the benefits of screening for long-term cardiac or pulmonary toxicity in asymptomatic cancer survivors who received chemotherapy, radiotherapy, or trastuzumab were identified. The reviewed literature included primarily retrospective and cross-sectional studies describing the incidence of cardiac and pulmonary late effects. Anatomic and/or functional abnormalities have been associated with use of all currently available anthracyclines and their derivatives. Trastuzumab-related cardiac dysfunction rarely causes death, and in most cases is reversible with improvement in cardiac function on drug discontinuation and/or treatment with cardiac medications. The estimated aggregate incidence of radiation-induced cardiac disease is 10% to 30% by 5 to 10 years post-treatment, although the incidence may be lower with modern techniques. Radiation pneumonitis is reported in 5% to 15% of lung cancer patients receiving definitive external-beam radiation therapy. A minority of patients may develop progressive pulmonary fibrosis; late complications include cor pulmonale and respiratory failure. Bleomycin-induced pneumonitis is an acute rather than late effect of treatment. Late pulmonary complications in bone marrow or stem cell transplantation patients who develop interstitial pneumonitis include idiopathic pneumonia syndrome and bronchiolitis obliterans. CONCLUSION An increased incidence of cardiac and/or pulmonary dysfunction is observed in cancer survivors. Research is needed to identify high-risk patients, and to determine the optimal screening strategies and subsequent treatment.
Genome Sequence of an Endophytic Fungus, Fusarium solani JS-169, Which Has Antifungal Activity

ABSTRACT An endophytic fungus, Fusarium solani strain JS-169, isolated from a mulberry twig, showed considerable antifungal activity. Here, we report the draft genome sequence of this strain. The assembly comprises 17 scaffolds, with an N50 value of 4.93 Mb. The assembled genome was 45,813,297 bp in length, with a G+C content of 49.91%.
Computationally-efficient multi-objective optimization of antenna structures using point-by-point Pareto set identification and local approximation surrogates

The paper presents a computationally-efficient methodology for multi-objective optimization of antenna structures. In our approach, the set of designs representing the best possible trade-offs between conflicting objectives is obtained by moving along the Pareto front and identifying the subsequent Pareto-optimal solutions using surrogate-based optimization techniques. For the sake of computational efficiency we also utilize coarse-discretization electromagnetic (EM) simulations and local response surface approximation models. The proposed approach is demonstrated using a ultrawideband dipole antenna with the 9-element representation of the Pareto front obtained at the total cost corresponding to only 30 evaluations of the high-fidelity EM antenna model.
Viscoelasticity of F-actin and F-actin/gelsolin complexes.

Actin is the major protein of eukaryote peripheral cytoplasm where its mechanical effects could determine cell shape and motility. The mechanical properties of purified F-actin, whether it is a viscoelastic fluid or an elastic solid, have been a subject of controversy. Mainstream polymer theory predicts that filaments as long as those found in purified F-actin are so interpenetrated as to appear immobile in measurements over a reasonable time with available instrumentation and that the fluidity of F-actin could only be manifest if the filaments were shortened. We show that the static and dynamic elastic moduli below a critical degree of shear strain are much higher than previously reported, consistent with extreme interpenetration, but that higher strain or treatment with very low concentrations of the F-actin severing protein gelsolin greatly diminish the moduli and cause F-actin to exhibit rheologic behavior expected for independent semidilute rods, and defined by the dimensions of the filaments, including shear rate independent viscosity below a critical shear rate. The findings show that shortening of actin filaments sufficiently to permit reasonable measurements brings out their viscoelastic fluid properties. Since gelsolin shortens F-actin, it is likely that the effect of high strain is also to fragment a population of long actin filaments. We confirmed recent findings that the viscosity of F-actin is inversely proportional to the shear rate, consistent with an indeterminate fluid, but found that gelsolin abolishes this unusual shear rate dependence, indicating that it results from filament disruption during the viscosity measurements. (ABSTRACT TRUNCATED AT 250 WORDS)