Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of craniosynostoses

This work evaluated the safety and effectiveness of operative techniques used in cranioplastic surgery and outcomes of these surgical methods. In study I the feasibility of endocranial fixation in frontal remodeling surgery for metopic and coronal synostosis was established. Good to excellent aesthetic results were seen in 96% of cases evaluated by a surgeon at the time of follow-up. Three patients out of 27 had complications requiring revisions. No mortality or permanent morbidity, nor complications related to endocranial placement of the plates were seen. Thus it was verified that placing resorbable material intracranially reduces the aesthetic impact without hindering the final result. Study II found that posterior cranial vault distraction procedures produced a mean increase of 25% in intracranial volume. This proved to be an effective technique for treating a variety of craniosynostosis with significant shortage of intracranial volume. 3D photogrammetric imaging was found to be a suitable non-ionizing method for evaluation of cranial volume increase following distraction. In study III a new tool was developed and successfully used for the intraoperative guidance of distractor device placement to ensure congruent vectors and thus reduced complications of these surgical procedures. In study IV long-term functional and aesthetic outcomes of the surgical treatment for sagittal synostoses in patients reaching adulthood was examined. The mean follow-up time was 26.5 years and the patients were 18 to 41 years old at the time of follow-up. The patients treated for sagittal synostosis were equally satisfied with their facial appearance as were their age and gender matched controls. Independent panels found patients’ appearance to be slightly less attractive, but the difference was less than 10 mm on a 100 mm Visual Analogue Scale, representing a low clinical significance. Patients’ socioeconomic situation such as education, housing, employment and marital status equaled controls with similar frequencies of headaches, mental problems or health issues as the controls.
Clinical outcomes of estrogen receptor (ER)-negative and progesterone receptor (PgR)-positive invasive breast cancer.

567 Background: Hormone receptor (HR) expression has prognostic and predictive significance in breast cancer. Most HR-positive tumors are ER positive (ER+). In contrast, tumors that are ER negative (ER-) and PgR positive (PgR+) are uncommon and may represent an analytic artifact. We have previously shown that ER-/PgR+ tumors have been associated with younger age, higher grade, and Her2/neu over-expression suggesting a distinct biologic entity (Proceedings 103rdUSCAP Meeting). Here we evaluated clinical outcomes of ER-/PgR+ breast cancers. Methods: We retrospectively reviewed a well-characterized database comprising 816 sequential patients diagnosed with early stage invasive breast carcinoma in Salamanca, Spain. Outcomes of interest were time to relapse (TTR) and overall survival (OS). Multivariable Cox proportional hazards analysis was conducted to assess the association of ER-/PgR+ with TTR and OS in comparison to ER+ and to ER- and PgR negative (ER-/PgR-) tumors. Results: Fifty-six patients (7%) had ER-.
Etude de la réfraction d'une nappe laser dans un film d'eau, application à la mesure de champ de vitesse par PIV

Une methode de mesure de type Velocimetrie par images de particules (PIV) adaptee aux mesures en espaces confines et basee sur la refraction de la nappe laser a l'interface entre le hublot transparent et l'ecoulement est presentee dans ce travail. L'analyse optique de l'eclairement des particules ensemen-cant l'ecoulement est effectuee par l'utilisation d'un modele a rayon puis par la mesure de l'intensite lumineuse dans l'ecoulement. Cette analyse permet ensuite l'etude critique des champs de vitesse obte-nus par cette methode de mesure vis a vis de la structure de l'ecoulement.
Protective anti-prion antibodies in human immunoglobulin repertoires

Prion immunotherapy may hold great potential, but antibodies against certain PrP epitopes can be neurotoxic. Here we identified >6000 PrP-binding antibodies in a synthetic human Fab phage display library, 49 of which we characterized in detail. Antibodies directed against the flexible tail of PrP conferred neuroprotection against infectious prions. We then mined published repertoires of circulating B cells from healthy humans and found antibodies similar to the protective phage-derived antibodies. When expressed recombinantly, these antibodies exhibited anti-PrP reactivity. Furthermore, we surveyed 48’718 samples from 37’894 hospital patients for the presence of anti-PrP IgGs, and found 21 high-titer individuals. The clinical files of these individuals did not reveal any enrichment of specific pathologies, suggesting that anti-PrP autoimmunity is innocuous. The existence of protective anti-prion antibodies in unbiased human immunological repertoires, combined with the reported lack of such antibodies in carriers of disease-associated PRNP mutations, suggests a link to the low incidence of spontaneous prion diseases in human populations.
The Relationship between Emotional Intelligence and Self-Efficacy in Type II Diabetes Patients

Objective: The theory of self-efficacy is based on the assumption that people’s beliefs about their abilities and talents have a favorable effect on their actions. It is the most important determinant of behavior. This study aimed to investigate the relationship between Emotional Intelligence (EI) and self-efficacy in type II diabetes (T2DM) patients. Materials and Methods: In this analytical cross-sectional study, 128 T2DM patients were selected via simple random sampling. At first, the patients’ demographic data were recorded. Then, the persian version of Diabetes Management Self-Efficacy Scale (DMSES) and EI questionnaire developed by Petrides and Furnham were completed. Results: The mean (±SD) age of the patients was 53.55 (±6.2) years. The results showed a significant positive correlation between the total scores of self-efficacy and EI ( P -value: 0.001). Accordingly, increase in the EI score was accompanied with an increase in the score of self-efficacy. Conclusion: EI plays an important role in nurturing self-efficacy beliefs and positive self-concepts in patients and promoting their mental and physical health status. Hence, training courses on EI components can make patients feel highly self-efficacious.
Bone remodeling and biological effects of mechanical stimulus

This review describes the physiology of normal bone tissue as an introduction to the subsequent discussion on bone remodeling and biomechanical stimulus. As a complex architecture with heterogeneous and anisotropic hierarchy, the skeletal bone has been anatomically analysed with different levelling principles, extending from nano- to the whole bone scale. With the interpretation of basic bone histomorphology, the main compositions in bone are summarized, including various organic proteins in the bone matrix and inorganic minerals as the reinforcement. The cell populations that actively participate in the bone remodeling—osteoclasts, osteoblasts and osteocytes—have also been discussed since they are the main operators in bone resorption and formation. A variety of factors affect the bone remodeling, such as hormones, cytokines, mechanical stimulus and electromagnetic stimulus. As a particularly potent stimulus for bone cells, mechanical forces play a crucial role in enhancing bone strength and preventing bone loss with aging. By combing all these aspects together, the information lays the groundwork for systematically understanding the link between bone physiology and orchestrated process of mechanically mediated bone homoestasis.
Current Therapy in Autoimmune Bullous Diseases

The goal of the treatment of autoimmune bullous disease is to reduce the production of pathogenic autoantibodies or increase elimination of pathogenic autoantibodies from serum of the patients. Immunosuppressive therapy reduces the production of autoanti- bodies. The therapy protocol is divided into three phases. The first is a control phase with the highest dose of immunosuppressive drugs suppressing activity of disease, followed with a consolidation phase, when the bulk of lesions is healed. The last phase is a maintenance phase when immunosuppressive medication is gradually tapered to the lowest level that suppresses the appearance of new lesions. In complete remission off therapy, the patient reached complete clinical remission and does not use any immuno- suppressive medication. In complete remission on therapy, the patient uses a minimal immunosuppressive therapy. The first-line treatment is corticosteroids in pemphigus and pemphigoid groups. Adjuvant immunosuppressive drugs are combined with systemic corticosteroids and display a corticosteroid sparing effect. First-line immunosup- pressive adjuvants comprise azathioprine, mycophenolate mofetil and mycophenolic acid. Rituximab, intravenous immunoglobulin G, immunoadsorption, cyclophospha- mide, dapsone, and methotrexate are regarded as the second-line adjuvants. In dermatitis herpetiformis, a gluten free diet eliminates the clinical symptoms. Dapsone is regarded to be a valid therapeutic option in management of dermatitis herpetiformis. mechanisms affecting the pathophysiology of the Some yield in suppression some have Immunosuppressive activity is used in mycophenolate mofetil, cyclophosphamide, methotrexate, and activity suppressing includes The topical immunomodulatory agents, calcineurin inhibitors, are new choice in local management of autoimmune bullous disease that promote healing and may enhance reepithelization. A double-blind, placebo-controlled clinical study referred to the good efficacy and safety profile of pimecrolimus 1% cream for cutaneous lesions in 11 patients with pemphigus vulgaris [127]. Another new topical agent, epidermal growth factor (10 μ g in cream) was evaluated in a double-blind, randomized, controlled clinical trial and showed accelerating efficacy and a good safety profile in 20 patients with cutaneous lesions of pemphigus vulgaris [128]. Nicotinamide gel 4%, an adjunctive topical gel, was referred as an effective new treatment modality for cutaneous lesions of pemphigus vulgaris in 8 patients in a double-blind, placebo-controlled study [129]. All new topical medications should be confirmed in large clinical studies and eventually in practice.
There's No Time like the Present: Improving the Current System of Care for Low-Income Substance Abusers with Comorbid Health Conditions

Due to social determinants of health, people living in poverty are at high risk for having comorbid substance use and medical disorders, yet are also the least able to afford and access the care needed to adequately address their health. There has been a recent call for providing integrated care for behavioral and physical health problems, yet there are challenges to fully integrating the two systems. In this article, several suggestions for improving the current system of care for low-income individuals are presented. Suggestions are derived from components of the chronic care model, the model underlying most conceptions of integrated care, and include increasing the use of technology and interdisciplinary teams to supplement assessment and intervention.
Identification of Culicidae Family Diversity as Vector Control Management and Mosquito-Borne Disease Prevention in Universitas Gadjah Mada, Yogyakarta

Introduction: Family Culicidae was the presence of a mosquito that had a potential vector to cause the spread of dengue fever and some diseases. Mosquito diversity could be different due to human and environmental factors in those regions. This study aims to identify mosquito (family Culicidae) diversity and characteristics of breeding places as vector control management and mosquito-borne disease prevention in the area of Universitas Gadjah Mada, Yogyakarta. Method: The study was conducted from April to September 2018. A sampling of mosquito larvae and observation of mosquitoes breeding places characteristics were carried out inside and outside the Universitas Gadjah Mada campus building which was divided into 5 clusters, there were Science and Engineering cluster, Medica, Agro, Vocational School, and Social Science. Mosquito diversity in the Universitas Gadjah Mada campus area was analyzed used the Shannon-Wienner diversity index. Result and Discussion: Mosquitoes found in the area of Universitas Gadjah Mada consist of two phases with total number 153 larvae and pupae, namely Aedes aegypti, Aedes albopictus, Anopheles spp. , and Culex spp. The mosquito with the highest number of larvae and pupae was Aedes albopictus, while Anopheles spp. Only found 1 pupa phase. The number of obtained containers was 50 containers, with 6 positive containers of mosquito larvae. Mostly, the type of container found with mosquito larvae was bucket. For each container observed, the temperature and pH of water in the container were measured and it was found that the water temperature reached 24 – 28°C with pH 6 – 7. Conclusion: Mosquito diversity from all of the areas in Universitas Gadjah Mada was grouped as a medium category, with the greatest number of mosquito larvae were found in Science and Engineering cluster. Containers were located in the open area had more mosquito larvae. Mosquito control is focused on environmental management, biological control, and chemical use.
Implication of Delayed Cord Clamping for Reducing Anaemia in Term Infants

Objective: This study was carried out to assess whether delayed cord clamping is effective in improving the haematological status of term infants born to anemic mothers and whether this is associated with complications in infants and mothers. Methods: we randomly assign women delivering vaginally term babies in Lady Willingdon Hospital Lahore to immediate cord clamping (ICC, n=100) or delayed cord clamping (DCC, n=100) and follow their infants until the age of 3months. We compared infant hemoglobin change from cord value. Secondary outcomes were related to infant and maternal safety. Results: infant hemoglobin level at b3months declined in both groups but more in group of immediate cord clamping. Mean infant Hb at 3months in ICC group was and bin DCC group was. Difference of Mean infant Hb in ICC group was and in DCC group was. No adverse events were seen in infants and mother. Conclusion: DCC improved the heamatological status of term infants born to anemic mothers. It is a simple, safe and cost free intervention to reduce early infant anemia risk.
Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats

Background: Rhizome of Curcuma longa has many therapeutic implications in traditional Indian medicine. It is used in traditional medicine for flatulence, dyspepsia, and other gastric problems. There is conflicting reports regarding its antiulcer and ulcerogenic potential. Aims and Objectives: The study is with the aim of determining the gastoprotective effect of C. longa extract on aspirin-induced gastric ulcer in rats. Materials and Methods: C. longa rhizomes were collected locally. Preparation of extract was done with 50% ethanol using Soxhlet extraction. Albino rats of Wistar strain were used for the study. Aspirin was purchased from Sigma Labs, Mumbai. Anti-ulcer effect of the extract was studied in rats after inducing mucosal damage by aspirin. Results: It was found that extract of C. longa exhibited significant protection against aspirin-induced ulcer at dose levels of 250-mg/kg, 500-mg/kg, and 1000 mg/kg body weight. There is a dose-dependent increase in the ulcer protective action of the extract. Conclusion: The present study with extract of C. longa revealed its anti-ulcer activity.
"At First It was Annoying": Results from Requiring Writers in Developmental Courses to Visit the Writing Center

From fall 2013 through spring 2016, 1,301 students were enrolled in composition courses on our regional campus, with 349 of these enrolled in developmental courses. Our writing center serves approximately 14% of the campus population every year, a number we have seen increase since two professors in 2013-2014 began requiring students in their developmental courses to attend a minimum number of writing sessions each semester. The D-F-withdrawal rates for developmental writing courses on our campus have averaged 32.7% over the past six semesters, an improvement over previous years. Analysis of data from a study of student outcomes during this period demonstrates that requiring frequent visits to the writing center in early semesters results in a statistically significant, positive relationship with increased passing rates and voluntary usage of the writing center.
Simulator Edukatif untuk Pembelajaran Algoritma Rapidly-exploring Random Tree (RRT)

Abstrak – Paper ini mempresentasikan perancangan dan penggunaan simulator pendidikan untuk membantu pengajaran materi perencanaan gerak menggunakan algoritma Rapidly-exploring Random Tree (RRT). Simulator ini dibuat menggunakan Laboratory Virtual Instrumentation Engineering Workbench (LabVIEW). Pada simulator pendidikan ini dibuat juga beberapa variasi dari RRT, yaitu RRT*, bi-RRT dan RRT biased. Keunggulan dari simulator ini adalah setiap subproses dari algoritma RRT dapat divisualisasikan sehingga akan membantu meningkatkan pemahaman dalam pembelajaran algoritma ini. Parameter-parameter dari algoritma RRT juga dapat dengan mudah dimodifikasi sehingga dapat diamati pengaruhnya pada performansi keluaran dari RRT. Pengujian performansi simulator dilakukan dengan membandingkan implementasinya pada beberapa kasus benchmark yang ada. Karena salah satu hal penting dalam algoritma perencanaan jalur adalah mengenai waktu komputasi, maka pembuatan software simulator ini telah diefisiensikan agar diperoleh waktu komputasi sistem yang minimal. Menggunakan salah satu kasus benchmark pada perencanaan jalur, algoritma RRT yang dirancang mampu menyusun jalur dalam waktu 185 milidetik adapun jika menggukan algoritma RRT*, perencanaan jalur dapat selesai dirancang dalam waktu 1273 milidetik. Salah satu yang dilakukan agar meminimalkan waktu komputasi ini adalah dengan cara meminimalkan overhead pada program subVI. Overhead pada subVI diminimalkan dengan menjadikannya sebagai subroutine. Karena itu, pada perancangan simulator ini juga dihindari penggunaan fungsi-fungsi pada LabVIEW yang tidak bisa dijadikan sebagai subroutine. Dengan memanfaatkan simulator ini diharapkan dapat membantu mahasiswa untuk mendapatkan pemahaman yang lebih baik mengenai algorima perencanaan gerak menggunakan RRT. Kata Kunci : Perencanaan gerak, Rapidly-exploring Random Tree, simulator, variasi RRT, visualisasi proses
Influence of skewing design for reduction of force ripples in DSL-SynRM using 3D FEA

1 Abstract —Double Sided Linear Synchronous Reluctance Motors (DSL-SynRM) are being increasingly used in high force density applications. The force ripples are one of the major issue in machine which is due to nonlinear nature of current in the machines. This paper focuses on the reduction of force ripples for increasing the force density of the motor. In order to reduce the force ripples, DSL-SynRM with a skewed translator is proposed. The proposed structure is designed and developed by using computational magnetic tools. This concept is effective for reduction of the force ripples and improves the force density of the machine. The proposed design has been reduced the percentage of force ripples by 21.62 %, improved the force density by 10.32 N/mm³ and efficiency by 0.89%.
Endocrine Therapy in Older Women with Early-Stage Hormone Sensitive Breast Cancer

Breast cancer is the most common cancer affecting women worldwide, with the highest risk in those aged 70 and over. Most older women (80% to 85%) have hormone receptor positive breast cancer and thus the use of endocrine therapy is common in this population. Typically, women receive endocrine therapy for at least 5 years to reduce the risk of cancer recurrence and decrease breast-cancer mortality. However, adherence to hormonal therapy may be an issue, particularly in older women, as side effects may lead to early discontinuation and/or non-adherence. Older women on endocrine therapy are often cared for by primary care physicians and geriatricians and therefore, an understanding of oral endocrine therapy, as well as its potential side effects, is essential for treating physicians. This review describes the benefits of endocrine therapy in patients with resected breast cancer, compare different hormonal therapies with regards to side-effects and discuss management strategies with a particular focus on the concerns of older breast cancer patients on endocrine therapy. Mrs. Smith is a 75-year-old woman whose family doctor noted a 3 cm to 4 cm lump in her left breast during a routine physical exam. She has no palpable lymph nodes. Her family doctor sends her for a mammogram which reveals a 2.6 cm spiculated mass in the left upper outer quadrant. Biopsy reveals an invasive ductal carcinoma.
EFFECT OF AGING ON RANGE OF MOTION AND FUNCTION OF DOMINANT SHOULDER JOINT IN HEALTHY GERIATRIC POPULATION

EFFECT OF AGING ON RANGE OF MOTION AND FUNCTION OF DOMINANT SHOULDER JOINT IN HEALTHY GERIATRIC POPULATION Anshika Singh 1, Sumit Raghav *1, Gaurav Pratap Tyagi 2, Arvind Kumar Shukla 3. 1 Assistant Professor, Subharti College of Physiotherapy, Meerut, India. 2 Clinical Physiotherapist, Subharti College of Physiotherapy, Meerut, India. 3 Assistant Professor, Statistician, Subharti Medical College, Meerut, India.
Starka som individer men svaga som grupp

Reforms had been performed in primary health care in recent years. Swedish district nurses have a long tradition as professional caregivers to our communities. Few studies have investigated what happens with the work situation and the professional role of the district nurse during later years. The aim of this paper is to describe how district nurses perceive their work situation and how they view their profession in the modern society. Focus groups interviews are used as empirical input and were carried out in Stockholm in 2003–04. Data is processed through a qualitative analysis, and the results are presented in six themes. The study indicates that district nurses may have difficulties to uphold their professional demands, which could lead to reduced autonomy and control over their work situation, less opportunities to use and develop their personal competence, and that district nurses as a group might have an indistinct professional role in primary health care and in the society.
HIV Antiretroviral Drug Resistance: What’s new in Mali? What is the future?

La resistance aux antiretroviraux prend une grande ampleur avec la disponibilite de plus en plus des de ces traitements au Mali, surtout dans un contexte ou les laboratoires ont des capacites limitees a offrir des outils virologiques pour un suivi optimal.