Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyse und Validierung vorausschauender Sensormodelle in einer integrierten Fahrzeug- und Umfeldsimulation

Die starke Zunahme von vorausschauenden Assistenzfunktionen verbunden mit der gestiegenen Anzahl an Fahrzeugvarianten fuehrt zu erheblich erhoehten Testaufwaenden fuer die zuverlaessige Absicherung von Fahrerassistenzsystemen (FAS). Diese Testaufwaende koennen nicht mehr alleine durch reale Versuchsfahrten abgedeckt werden. Vorgestellt wird eine Methodik zur teilautomatisierten Validierung der Sensormodelle einer computergestuetzten Umfeldsimulationsumgebung zum Test von FAS. Die Validierungsmethodik stuetzt sich hierfuer auf gespeicherte Referenzpositions- und Umfeldsensordaten aus realen Versuchsfahrten. Die Methodik gestattet den direkten Vergleich und die Bewertung von realen und synthetisch generierten Umfeldsensordaten auf Objektlistenebene fuer real eingefahrene Testszenarien. Erste Ergebnisse der Sensormodellvalidierung mit einem prototypischen realen Umfeldsensor und einem idealisierten Modell des Sensors belegen die grundlegende Eignung der Umfeldsimulationsumgebung zur Auslegung und zum Test vorausschauender Funktionen. Sie zeigen aber auch gegenwaertige Limitierungen auf, die in zukuenftigen Arbeiten zu adressieren sind. Der wesentliche Nutzen der vorgestellten Validierungsmethodik besteht in folgenden Gesichtspunkten: Erheblich reduzierter Zeitbedarf fuer die Generierung von virtuellen Testszenarien; die Moeglichkeit, validierte Aussagen ueber die Grenzen der verwendeten Sensormodelle zu treffen; Einbindung existierender und bewaehrter Tools fuer Analyse, Vergleich und Bewertung von Sensordaten sowie Nutzung eines einheitlichen Zieldatenformats fuer die Auswertung realer und synthetischer Sensordaten. Im Rahmen der Umsetzung und Anwendung der Methodik wurden auch die Hauptarbeitsfelder identifiziert, die in zukuenftigen Arbeiten zur Erhoehung der Aussagekraft der simulierten Sensordaten in Bezug auf den Test von FAS beitragen sollen. (A) Beitrag zum Themenbereich "Jahrmarkt der Innovationen" der 26. VDI/VW-Gemeinschaftstagung "Fahrerassistenz und Integrierte Sicherheit", Wolfsburg, 6. und 7. Oktober 2010. Siehe auch Gesamtaufnahme der Tagung, ITRD D366841.
Change Management as a Critical Success Factor in e-Government Implementation

Change Management as a Critical Success Factor in e-Government Implementation Change management in e-government implementation is a very complex issue. E-government services are frequently distributed over different IT systems and organizations. There are also events from outside the public administration that cause changes such as government policies and legislation, public-private partnership, etc., and finally a huge resistance to change exists in public administration proverbial. Another problem is that the e-government is predominantly seen only as a technology mission and not as an organizational transformation issue. Those are probably the main reasons that the existing literature about change management in e-government is still missing at large. There are articles dealing with some aspects of changes affected by the new technology implementation, however, there is no comprehensive framework that would identify changes that have to be managed in e-government implementation. Therefore, the main aim of the paper is to identify a comprehensive set of changes that have to be considered in e-government implementation and the role of leadership in such processes. Finally, the paper proposes a conceptual model of change management in e-government implementation.
Analysis of Integration Sites of Jaagsiekte Sheep Retrovirus in Ovine Pulmonary Adenocarcinoma

ABSTRACT Ovine pulmonary adenocarcinoma (OPA) is an infectious lung tumor of sheep caused by Jaagsiekte sheep retrovirus (JSRV). To test the hypothesis that JSRV insertional mutagenesis is involved in the oncogenesis of OPA, we cloned and characterized 70 independent integration sites from 23 cases of OPA. Multiple integration sites were identified in most tumors. BLAST analysis of the sequences did not disclose any potential oncogenic motifs or any identical integration sites in different tumors. Thirty-seven of the integration sites were mapped to individual chromosomes by PCR with a panel of sheep-hamster hybrid cell lines. Integration sites were found on 20 of the 28 sheep chromosomes, suggesting a random distribution. However, four integration sites from four different tumors mapped to chromosome 16. By Southern blot hybridization, probes derived from two of these sites mapped to within 5 kb of each other on normal sheep DNA. These sites were found within a single sheep bacterial artificial chromosome clone and were further mapped to only 2.5 kb apart, within an uncharacterized predicted gene and less than 200 kb from a mitogen-activated protein kinase-encoding gene. These findings suggest that there is at least one common integration site for JSRV in OPA and add weight to the hypothesis that insertional mutagenesis is involved in the development of this tumor.
Exploration de nouvelles approches pour les études de RCPG au niveau moléculaire : application aux récepteurs de chimiokines

Les recepteurs de chimiokines sont des regulateurs essentiels de la migration cellulaire dans le cadre de la surveillance immunitaire, et le developpement. Les recepteurs CCR5 et CXCR4 sont de plus specifiquement impliques dans les metastases cancereuses et l'infection par le VIH. Nous avons developpe un systeme permettant de sur-exprimer ces deux RCPGs. Afin de s'affranchir des problemes de toxicite inherents a l'expression des proteines membranaires en bacterie notre approche de production consiste a adresser les proteines vers les corps d'inclusion d'E. coli grâce a une fusion proteique N-terminale permettant de hauts niveaux d'expression. Apres purification en conditions denaturantes, les proteines sont alors repliees en presence de surfactants originaux, les amphipoles. La validation de cette nouvelle approche pour les recepteurs des chimiokines represente un des objectifs principaux de ce travail. Afin de tester la fonctionnalite des proteines repliees, une serie d'outils a ete developpee : des versions modifiees des chimiokines ont ete produites (RANTES pour CCR5 et SDF 1a pour CXCR4). La fonctionnalite des chimiokines a ete evaluee au niveau moleculaire et cellulaire. L'interaction entre le recepteur replie en amphipole et son ligand a ete teste par resonance de plasmons de surface (SPR). Differents types de surfaces fonctionalisees avec le recepteur de chimiokine replie en amphipole ont ete explores au cours de ce travail. A la fin de ce projet, la production des chimiokines et de leur recepteur a ete mise au point. L'acces a ces outils ouvre la voie a de futures etudes moleculaires telles que la comprehension de la dimerisation du recepteur ou la determination de la stoechiometrie du complexe.
Steven F . Harwin , MD Three-Year Outcomes of a Highly Porous Acetabular Shell in Primary Total Hip Arthroplasty

Cementless fixation has been used for approximately 3 decades. Cementless fixation became popular because it was thought to increase implant longevity, decrease the need for revisions when compared with cemented fixation, and preserve bone stock should a revision surgery be needed.1-3 It was established that survivorship of the implant was highly dependent on the implant’s ability to be incorporated in the patient’s native bone. Subsequently, many cementless implant designs were developed with varied clinical success. Recently, the use of highly porous titanium has increased, as these implants can successfully osseointegrate with patients’ native bone with low initial failure rates.4-6 The implants are able to achieve this because highly porous metal interfaces were specifically designed for increased biological fixation.7-10 Several studies have reported excellent survivorship and low complication rates for patients who underwent total hip arthroplasty (THA) and received highly porous acetabular shells.6,11 However, a recent comparative cohort single-center radiographic study that compared these cups with older generation cups showed higher rates of progressive radiolucencies on anteroposterior radiographs for the highly porous cohort at 5 years of follow-up.12 Two other studies that investigated this type of acetabular cup reported excellent cup osseointegration and no progressive radiolucencies.6,11 Because of the dichotomy of currently published literature, the authors performed a larger multicenter study. The purpose of this study was to evaluate outcomes of patients who underwent THA using a new highly porous titanium shell at minimum 3-year follow-up. Specifically, the authors assessed (1) aseptic and all-cause survivorship rates, (2) functional outcomes, (3) complications, and (4) radiographic outcomes.
[Pharmacokinetics of prednisone after oral administration in children with renal grafts. Changes induced by phenobarbital and renal insufficiency].

A study of blood and urinary clearance of prednisone after ingestion of a 25 mg/m2 body surface test-dose, at 8 AM, was undertaken in 20 children treated for 18 months with prednisone after renal transplant. Results show important variability between patients: the elimination half life was 2.70 +/- 0.78 hr. ; Tmax time to reach Cmax was 2.10 +/- 1.08 hr. ; Maximal concentration (Cmax) was 474 +/- 153 ng/ml. With respect to the dose of steroid administered, the urinary excretion of corticosteroids: 17-hydroxycorticosteroids was 12.9 +/- 7.4% and that of unchanged prednisolone 2.8 +/- 3.1%. This level was essentially achieved in the 6 first hours: 55.4 +/- 16.2% for 17-OH steroids and 87.2 +/- 14.3% for prednisolone. Two points emerge from this study: (a) Renal failure slows urinary excretion of prednisone and its metabolites, making a reduction in the doses of corticosteroids necessary at certain doses. (b) The association prednisone-phenobarbital changes the blood kinetics (excretion is faster) without a clear change in 17-OH steroid and prednisolone urinary excretion. It is associated with a decrease in graft tolerance. The kinetic changes do not seem to be the only factors implicated in the decreased therapeutic response.
Mandibular Distraction Osteogenesis for the Treatment of an Obstructive Sleep Apnea Patient with Orthognathic Anomaly: A Case Report and Literature Review

Objective: skeletal advancement in order to improve the airway dimensions is known as one of the most effective surgical theraphy for treating obstructive sleep apnea (OSA). Distraction osteogenesis (DO) can be a better treatment alternative in some selected cases similar to our patient. Using custom made distractors can make this technique more safe and successful. Study Design: Surgically assisted rapid palatal expansion (SARPE), bilateral intraoral mandibular distraction osteogenesis (MDO) and orthodontic treatment were tried to a 20-year-old OSA patient with orthognathic anomaly. For mandibular distraction, custom made distractors were used. Results: The initial AHI of the patient was 23.3. At the end of the treatment it decreased to 8.7. Conclusions: Distraction osteogenesis could be a better alternative than the conventional orthognathic surgery in this kind of selected patients. Customization of the distraction devices can contribute to making this procedure safer and more successful.
Academic Analytics in quality assurance using organisational analytical capabilities

The combination of increased environmental complexity and greater quantities of data presents higher education with new problems. Institutions have responded by adopting analytics-based approaches which aim to improve organisational and educational effectiveness. However, despite extensive research in academic analytics there is an identified need for further work in making analytics “actionable”, a problem of ‘IT in use’. Recent research in business analytics has investigated this problem using a business process orientation combined with an examination of business capabilities for analytics use. Adopting this perspective we apply it to academic analytics in the context of quality assurance, describing an outline approach to the problem of actionable academic analytics.
A Self-Balanced Step-Up Multilevel Inverter Based on Switched-Capacitor Structure

In this paper, a dc to ac converter with the ability of voltage increasing is presented. This inverter is designed in a way that just one dc source is used. Also, by using power storage technique and with combining charged capacitors and dc source in series form, output voltage levels can be increased. This inverter is in a modular structure and has the ability of capacitor's voltage self-balancing. H-bridge inverter was not used at the end of the proposed converter and all elements tolerate a voltage stress equal to the amount of input dc source. This leads to remarkable decrease of total standing voltage and peak inverse voltage. Other advantage of the proposed inverter is its potentiality of performance in high-frequency applications. The modular form of the proposed inverter provides the potentiality of extension to higher voltage levels and eases the maintenance. Moreover, considering to the fact that the stress of all components of the suggested inverter is equal to the input source, the performance in high voltage is added to the characteristics of the proposed inverter. The nine-level structure of the proposed inverter is simulated and laboratory test is carried out for the verification of its performance.
Fault-tolerant ripple-carry binary adder using partial triple modular redundancy (PTMR)

Integrated circuit chips fabricated using nano-scale CMOS technologies will be prone to errors caused by fluctuations in threshold voltage, supply voltage, electromigration, random dopant fluctuations, aging, timing errors and soft errors. Design of nano-scale failure-resistant systems has drawn significant interest in past few years. One common approach to reducing errors is the use of triple modular redundancy (TMR). The hardware overhead associated with TMR is significantly high. This paper presents a novel partial triple modular redundancy (PTMR) approach that achieves the same or better fault-tolerance as that of TMR but with significantly less hardware overhead. In a weighted number system, the most significant bits carry greater weight and preserving these bits is more critical than the lower significant bits. In PTMR, only the P most significant bits of the result are computed using TMR as opposed to all the W bits, where W represents the word-length of the operands. The proposed PTMR approach is illustrated in the context of a ripple-carry adder. It is shown that the hardware overhead can be reduced by 75% to 87.5% with P = 4 as the word-length varies from 16 to 32, with average error power equal to or less than that of TMR. It is shown that P = 3 or 4 is sufficient for word-lengths varying from 16 to 32.
Synovial macrophages.

The mononuclear phagocyte system in the synovial membrane is represented by specialised lining cells of the synovial intima and macrophages in the subintima and synovial fluid. ' In common with mononuclear phagocytes in other tissues, they are derived from a common bone marrow precursor and show certain functional and cytochemical characteristics. The most distinctive feature of these cells is their avid phagocytic ability, but their other functions include induction and regulation of hormonal and cellular immune responses, and formation and release of a large number of secretory products. The synovial membrane contains a distinctive intimal lining, one to two cells thick, composed of specialised synovial lining cells (SLCs). At least two cell types have been demonstrated ultrastructurally in the synovial lining:' 2 type A (macrophage like cells) which have prominent filopodia, vacuoles, vesicles, and poorly developed rough endoplasmic reticulum; and type B (fibroblast like) cells which have a well developed rough endoplasmic reticulum, and few vesicles, vacuoles or cell processes. A type C cell has also been identified, with features intermediate between those of type A and type B cells. These differences in ultrastructural morphology led to the hypothesis that A and B cells represent a single cell type with morphology reflecting functional status, and that the type C cell represented a precursor of the A and B cells.3 However, the distinct origin and lineage of the two cell types in the synovial membrane was established using radiation chimaeras of normal and beige mice which showed giant granules in 1-7% of ultrastructurally type A SLCs in the normal synovium. ' This was supported by analysis of the immunophenotype of SLCs, which showed the presence of several characteristic macrophage markers such as HLA-DR, Fc and C3 receptors on SLCs,5 6 in addition to strong expression of a wide range of leucocyte/macrophage antigens on both SLCs and subintimal macrophages (table). 7` These include expression of leucocyte common antigen (LCA), an epitope expressed by all
Antibody titers and plasma glucocorticoid concentrations near weaning in steer and heifer calves.

The involvement of adrenal glucocorticoids and immunologic competence has been under investigation in laboratory animals for many years. As early as 1936, Selye (16) reported that injury to rats or stressful stimuli could cause adrenal enlargement and thymic involution. More recent experimentation demonstrated that glucocorticoids are involved with depletion of cortical thymic lymphocytes and with depressions in germinal centre formation and lymphoid cell proliferation in the spleen of mice (4, 9, 14). In mice, the period of maximum sensitivity to glucocorticoid action on loss of spleenic mass and reduction of antibody production was between 24 and six hr prior to sheep red blood cell (SRBC) injection (8). Studies in which laboratory mice are subjected to crowding reveal that this stress leads to reduced antibody production following injections of SRBC and a decreased capability of the laboratory animals to resist parasitic invasion (2, 3). Although the literature abounds with data on the effects of stress on antibody production in laboratory animals (2, 3, 4, 8, 9, 12, 16), there is a relative paucity of information delineating stress involvement with humoral or cell mediated immunity in domestic animals. Research with chickens has demonstrated that stress and elevated blood glucocorticoid concentrations are involved with both humoral and cell mediated immunity (5, 6, 15, 19, 20). Thaxton et al (19) found no decline in antibody titers to SRBC when chickens were exposed to heat stress. However, adrenocorticotropin (ACTH) injections between 24 and nine hr prior to antigen injection reduced antibody titers. The objective of this study was to evaluate relationships of antibody production to porcine red blood cells (PRBC), equine red blood cells (HRBC) and plasma glucocorticoid concentrations near the stressful time of weaning in beef calves.
Continuous Ambulatory Peritoneal Dialysis with a High Flux Membrane

The standard peritoneal equilibration test (PET) was performed in 66 patients on CAPD. Patients were classified as low (n=5), low average (n=22), high average (n=27), and high (n=12) transporters based on the dialysate/plasma creatinine (D/P Cr) after 4 hour dwells. After an average time interval of 14 months on CAPD, indices of dialysis adequacy and nutrition were assessed. Based on monitoring of patient chemistries and drain volumes, peritoneal transport was considered stable during the interval. Instilled volumes and exchange tonicity were individualized in each patient to achieve combined renal and dialysis weekly creatinine clearance and KT/V urea that were not significantly different between groups. Overall, there were significant positive correlations of PET D/P Cr with dialysate albumin concentrations (r=0.30, p<0.02) and dialysate albumin losses (g/wk, r=0.27, p<0.04). There were significant inverse correlations with lean body mass (r=—0.26, p<0.03), drain volumes (r=—0.025, p<0.04), and KT urea by dialysis (L/wk, r=-0.24,p<0.05). High transporters had significantly (p<0.05) lower mean serum albumin, net protein catabolic rate (nPCR), lean body mass calculated from creatinine kinetics, and daily creatinine production (and presumably lower muscle mass) compared with one or more lower transport groups. In conclusion, we hypothesize that, in high transporters, use of more hypertonic exchanges with greater glucose absorption may inhibit appetite and nPCR; also, protein losses in drain volumes are increased. High transporters may require increased clearance and protein intake targets compared with other groups to maintain nutrition. Also, high transporters may be better suited for nightly intermittent peritoneal dialysis where short cycles provide more ultrafiltration with less glucose absorption.
Accurate Integration of Stochastic Climate Models with Application to El Nino

Numerical models are one of the most important theoretical tools in atmospheric research, and the development of numerical techniques specifically designed to model the atmosphere has been an important discipline for many years. In recent years, stochastic numerical models have been introduced in order to investigate more fully Hasselmann’s suggestion that the effect of rapidly varying ‘‘weather’’ noise on more slowly varying ‘‘climate’’ could be treated as stochastic forcing. In this article an accurate method of integrating stochastic climate models is introduced and compared with some other commonly used techniques. It is shown that particular care must be used when the size of rapid variations in the ‘‘weather’’ depends upon the ‘‘climate. ’’ How the implementation of stochasticity in a numerical model can affect the detection of multiple dynamical regimes in model output is discussed.
Developing a Small Business Management Concentration within a Business Degree

The first academic program in Israel with a concentration in small business management, as part of bachelor's degree in management, was launched with accreditation by the Council for Higher Education of Israel in 2016. While acknowledging the external environmental factors, such as government unfavorable bureaucracy and regulations, the objective of the program was to provide an education that will develop the skills to start and manage SMEs to increase the success rate of launching new entrepreneurial ventures and to manage and grow ongoing SMEs. The article provides details on a unique methodology and considerations that served to design the structure and content of the program and courses. This methodology and design could serve as a benchmark for similar programs elsewhere.
Glatiramer acetate in treatment‐naïve and prior interferon‐β‐1b‐treated multiple sclerosis patients *

Objective – This prospective, open‐label study evaluated the efficacy, safety, and tolerability of glatiramer acetate (GA) in treatment‐naïve relapsing–remitting multiple sclerosis (RRMS) patients and in patients who had previously received interferon‐β (IFN‐β)‐1b therapy.