Miracle-dz/UniFAR-FTUs huggingface dataset:
Las Maquiladoras Fronterizas, (Modelo Agotado?)

Los esfuerzos por parte de paises en desarrollo para actualizar su capacidad industrial ha llevado a Ia reorganizacion de sus sectores manufactureros. En Mexico Ia viabilidad de este modelo ha sido cuestionada debido al declive de Ia industria maquiladora a lo largo de Ia frontera. Dos razones que explican el declive son frecuentemente discutidas: primero, el aumento de Ia competitividad de paises como China, y segundo, los limites estructurales del modelo de industrializacion basado en exportaciones de manufacturas. Estearticuloargumentaquehayunimportantedebatesobreel futuro del modelo de Ia maquila, especialmente a lo largo de Ia frontera Mexico - Estados Unidos. Examinar si existe dentro de Ia maquila un proceso de evolucion que facilite el desarrollo de capacidades in­ house y de un ambiente institucional nos permitira determinar si el proceso de escalamiento industrial permite una transformacion positiva de los limites tradicionales de este sector. Este articulo concluye que el modelo mexicano de maquila en Tijuana y Ciudad juarez no esta agotado, pero que se enfrenta a grandes retos que resultan en Ia necesidad de las firmas de someterse a una continua reestructuracion.
Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells Producing IL15 Eradicate Established Pancreatic Tumor in Syngeneic Mice

Mesenchymal stem cells (MSC) represent a new tool for delivery of therapeutic agents to cancer sites because of their strong tropism toward tumors. IL15 has demonstrated a potent antitumor activity in various animal models as well as clinical trials. However, because of its short half-life, effective therapeutic effects usually require a high dose, which often results in undesired side effects; thus, new strategies for overcoming this disadvantage are needed. In this study, human MSCs were isolated from umbilical cord blood as delivery vehicles and transduced with lentivirus vector expressing murine IL15 (MSC-IL15). In vitro assays of lymphocyte activation and proliferation demonstrated that IL15 produced by MSCs was biofunctional. In syngeneic mice bearing Pan02 pancreatic tumors, systemic administration of MSC-IL15 significantly inhibited tumor growth and prolonged the survival of tumor-bearing mice, which were associated with tumor cell apoptosis, and natural killer (NK)– and T-cell accumulation. Furthermore, we confirmed that MSC-IL15 could migrate toward tumor and secreted IL15 in tumor-specific sites. Depletion of NK and CD8+ T cells abolished the antitumor activity of MSC-IL15, suggesting that NK and CD8+ T cells play a key role for MSC-IL15–mediated effect. Interestingly, cured mice after MSC-IL15 treatment were resistant to Pan02 pancreatic tumor rechallenge, and adoptive transfer of lymphocytes from cured mice also could cause rejection of Pan02 tumor inoculation in naïve mice, indicating that MSC-IL15 induced tumor-specific T-cell immune memory response. Overall, these data support that MSCs producing IL15 might represent an innovative strategy for therapy of pancreatic tumor. Mol Cancer Ther; 13(8); 2127–37. ©2014 AACR.
Privacy Preserving Against Network Intrusion Detection in Virtual Network System

Cloud security is one of most important issues that has attracted a lot of research and development effort in past few years. Particularly, attackers can explore vulnerabilities of a cloud system and compromise virtual machines to deploy further large-scale Distributed Denial- of-Service(DDoS). DDoS attacks usually involve early stage actions such as multi-step exploitation, low frequency vulnerability scanning, and compromising identified vulnerable virtual machines as zombies, and finally DDoS attacks through the compromised zombies. Within the cloud system, especially the Infrastructure-as-a-Service (IaaS) clouds, the detection of zombie exploration attacks is extremely difficult. This is because cloud users may install vulnerable applications on their virtual machines. To prevent vulnerable virtual machines from being compromised in the cloud, we propose a multi-phase distributed vulnerability detection, measurement, and countermeasure selection mechanism called NICE, which is built on attack graph based analytical models and reconfigurable virtual network-based countermeasures. Keyword: - Network Security, Cloud Computing, Intrusion Detection, Attack Graph, Zombie Detection.
Low Loss and Compact Grid Connecting Converter for Superconducting Magnet Using MERS

This paper proposes a new circuit topology for SMES (superconducting magnetic energy storage), which is based on a pulse link concept of two converters. A two quadrant dc chopper and a dc/ac converter connected via high frequency dc pulse link voltage. This concept has two advantages. All semi-conductor switches operate under soft-switching condition, which results in low loss generation and possibility to increase switching frequency. The other advantage is eliminating smoothing capacitor between two conversion stages. By these advantages, the proposed converter has possibility to achieve high efficiency and power density with rich controllability. This paper describes operation principles of the proposed converter. First experimental verification of this concept was conducted with small scale setup.
El propilenglicol mejora los resultados de la transferencia de embriones

La administracion oral de propilenglicol mejora la calidad del cuerpo luteo y los niveles sericos de progesterona, tambien permite seleccionar una mayor proporcion de receptoras para la transferencia y aumenta los indices de gestacion y parto, por lo que su empleo puede mejorar el beneficio economico en el campo y en la industria de la transferencia de embriones. La transferencia de embriones, es una tecnica reproductiva que permite acortar el intervalo generacional mejorando asi la ganancia genetica anual. Actualmente, esta tecnica se utiliza mundialmente, pero durante la ultima decada ha progresado poco, especialmente en aspectos relacionados con la respuesta a los tratamientos de superovulacion y con la mejora de los indices de gestacion. Tras la superovulacion y el lavado, los embriones recogidos de una hembra donante se clasifican segun su morfologia y estadio de desarrollo y, posteriormente, se congelan o se transfieren a receptoras. Al mismo tiempo, se debe decidir cual de las receptoras disponibles deberia recibir embriones para conseguir el mayor numero de gestaciones (Wrigth, 1981). El exito de la transferencia de embriones depende, en su mayor parte, de factores relacionados con el embrion (fresco o congelado, estadio de desarrollo y calidad), la receptora (la morfologia del cuerpo luteo, la concentracion de progesterona –P4– en plasma y la condicion corporal) y la existencia de sincronia del ciclo estral entre el embrion y la receptora. El propilenglicol (PPG) es un precursor glucogenico ampliamente utilizado contra la cetosis, via oral, con el fin de incrementar el porcentaje molar de propionato ruminal en vacuno lechero durante el post-parto (Emery et al., 1967). La cetosis, resultado de un deficit en el balance energetico, es perjudicial para el crecimiento folicular y la actividad del cuerpo luteo (Roche et al., 2000). Tras la administracion oral, una porcion de propilenglicol se metaboliza a propionato (Emery et al, 1967), pero la mayoria sale del rumen sin transformar para ser convertido en glucosa por el higado, principalmente a traves de la ruta del lactaldehido, con oxidacion a lactato (Miller y Bazzano, 1995). El propionato es transportado al higado a traves del sistema portal, donde se transforma en piruvato y finalmente en glucosa via oxalacetato (Emery et al., 1967), (Grafico 1). El objetivo de este estudio fue determinar la capacidad de una administracion sostenida de propilenglicol para estimular los resultados reproductivos y mejorar el porcentaje de gestaciones tras la transferencia de embriones bovinos obtenidos in vivo congelados/descongelados. Y contribuir a explicar los mecanismos de accion del propilenglicol analizando sus efectos sobre la progesterona, insulina, factor de crecimiento semejante a la insulina (IGF-1), glucosa, urea y trigliceridos.
Mixing project management and distance education: a case study

During Spring 1999, software project management students at East Tennessee State University produced a plan for a database publishing system. These students, who attended classes at geographically separate sites, contended with several problems related to working at a distance: creating a common repository for project artifacts, maintaining effective communications, and building a sense of "team". Geographic separation, though a challenge, proved less of an obstacle than other, more basic problems in project management. In spite of its problems, the project succeeded to a large extent, and pleased the client, students and instructor alike. The authors believe the project's success demonstrates the feasibility of distance-based coursework in software management-particularly in settings where an experienced instructor can help students to coordinate work at a distance.
Role of albumin in cirrhosis: from a hospitalist’s perspective

ABSTRACT Albumin, a negatively charged globular protein encoded on chromosome 4, is one of the most abundant proteins in the plasma and accounts for approximately 75% of plasma oncotic pressure. The role of albumin in the management of various disease states has shown to be beneficial historically. Low serum albumin is a predictor of mortality and poor outcomes. In cirrhotics undergoing paracentesis, albumin infusion prevents rapid re-accumulation of ascitic fluid while simultaneously decreasing the risk of post-paracentesis related circulatory dysfunction. Additionally, albumin is utilized in patients with hepatorenal syndrome (HRS) and spontaneous bacterial peritonitis (SBP). Overall, albumin appears to be an effective pharmacological agent in the management of cirrhosis and its complications.
Intuition

Faced with today’s ill-structured business environment of fast-paced change and rising uncertainty, organizations have been searching for management tools that will perform satisfactorily under such ambiguous conditions. In the arena of managerial decision making, one of the approaches being assessed is the use of intuition. Based on our definition of intuition as a non-sequential information-processing mode, which comprises both cognitive and affective elements and results in direct knowing without any use of conscious reasoning, we develop a testable model of integrated analytical and intuitive decision making and propose ways to measure the use of intuition.
Handoff optimization and load balancing in wireless LANs using association control

As users move around in wireless local area networks, they associate with different access points in succession to maintain connectivity. Without the carefully designed association control policy, it may lead to frequent handoffs and imbalanced load, which can potentially incur unacceptable delays and poor throughput. While existing works to this issue mainly focus on minimizing the number of handoffs over time, in this paper, we propose a new association control scheme with the goal of reducing the frequency of handoffs and balancing load among access points. The defined problem, handoff optimization and load balancing (HOLB,) is mathematically described as a minimum–maximum programming. Since the HOLB problem is a nondeterministic polynomial‐time hard, two constant approximation algorithms are presented to resolve it. First, we propose an α‐approximation( α ⩾2 ) centralized algorithm CHOLB. CHOLB employs a novel method to simplify the original problem to the minimum‐cost maximum‐flow problem, which is solved in polynomial time. On the sis of CHOLB, we then put forward a β‐approximation ( β ⩾2 ) distributed algorithm DHOLB for the purpose of scalability and lightweight. DHOLB partitions the network into clusters and uses CHOLB as its local centralized algorithm within each cluster. Extensive evaluations show that the proposed algorithms outperform the existing schemes in terms of the handoff frequency and traffic load. Copyright © 2013 John Wiley & Sons, Ltd.
Estimation of Component and Parameter Distributions in Spectral Analysis

A method is presented for estimating the distributions of the components and parameters determined with spectral analysis when it is applied to a single data set. The method uses bootstrap resampling to simulate the effect of noise on the computed spectrum and to correct for possible bias in the estimates. A number of bootstrap procedures are reviewed, and one is selected for application to the kinetic analysis of positron emission tomography dynamic studies. The technique is shown to require minimal assumptions about noise in the measurements, and its small sample properties are established through Monte-Carlo simulations. The advantages and limitations of spectral analysis with bootstrap resampling for deriving inferences for tracer kinetic modeling are illustrated through sample analyses of time-activity curves for [18F]fluorodeoxyglucose and [15O]-labeled water.
Epstein-Barr Virus BHRF1 Micro- and Stable RNAs during Latency III and after Induction of Replication

ABSTRACT Epstein-Barr virus (EBV) microRNAs miR-BHRF1-1, -2, and -3 have been detected in latency III-infected lymphoblasts, where they are encoded within EBNA transcripts (X. Cai, A. Schafer, S. Lu, J. P. Bilello, R. C. Desrosiers, R. Edwards, N. Raab-Traub, and B. R. Cullen, PLoS Pathog. 2:e23, 2006). In latency III-infected lymphoblasts, we have also identified a stable 1.3-kb RNA, which begins 3′ to miR-BHRF1-1, includes the BHRF1 open reading frame, and ends near miR-BHRF1-2. This 1.3-kb RNA is the residue of Drosha cleavage of the BHRF1 microRNAs from EBNA transcripts. Early after induction of EBV replication in latency I-infected Akata lymphoblasts, BHRF1 spliced 1.4-kb mRNA accumulated along with low levels of miR-BHRF1-2 and -3 and a 0.9-kb Drosha or miR-BHRF1-2 cleavage product of BHRF1 mRNA. The turning on of latency III infection at 48 to 72 h after induction of EBV replication was associated with higher miR-BHRF1-1, -2, and -3 levels; accumulation of the 1.3-kb RNA residue in the nucleus; abundant BHRF1 spliced 1.4-kb mRNA in the cytoplasm; and more abundant 0.9-kb mRNA cleavage product in the cytoplasm. These findings implicate miR-BHRF1-2 in 3′ cleavage of BHRF1 mRNA in the cytoplasm and Drosha in cleavage of latency III EBNA and EBV replication-associated BHRF1 transcripts in the nucleus.
The Association Between Diabetes and Dementia Among Elderly Individuals

Background/Aim: To date, few studies have cross-examined the relationship between diabetes mellitus (DM) and dementia nationally. There is also a lack of evidence regarding dementia subtypes and how this relationship changes among older individuals. The objective was to better delineate this relationship and influence of multiple comorbidities using a nationwide sample. Methods: Data were obtained from the Nationwide Inpatient Sample 1998 to 2011 using appropriate International Classification of Diseases, Ninth Version codes. Descriptive and bivariate analysis was performed. Multivariate nominal logistic regression models adjusted for age, sex, race, and comorbidities explored the independent relationship between Alzheimer dementia (AD), non-Alzheimer dementia (VaD), and diabetes. Results: 21% of the participants were diabetic patients, 3.7% had AD, and 2.2% had VaD. Diabetes prevalence in AD, VaD, and no dementia groups were 20.6%, 24.3%, and 26.2%, respectively. In the unadjusted model, those with DM had lower odds of AD (odds ratio [OR] 0.73; 95% confidence interval [CI] 0.72-0.74) and VaD (OR 0.91, 95% CI 0.89-0.92). Adjusting for age, sex, race, and comorbidities, diabetic patients had significantly higher odds of VaD (OR = 1.10, 95% CI 1.08-1.11) and lower odds of AD (OR 0.87, 95% CI 0.86-0.88). Inclusion of interaction terms (age, race/ethnicity, depression, stroke, and hypertension) made the relationship between diabetes and VaD not significant (OR 1.002, 95% CI 0.97-1.03), but the relationship of DM with AD remained significant (OR 0.57, 95% CI 0.56-0.58; P < .05). Conclusion: Patients with a diagnosis of diabetes mellitus had lower odds of having AD. Age, race/ethnicity, depression, stroke, and hypertension modified the relationship between DM and both VaD and AD. Further exploration of the relationship between DM and AD is warranted.
Epidemiologic issues.

Four major chronic orofacial pain conditions were identified: temporomandibular disorders (TMD), trigeminal neuralgia, atypical facial pain, and buming mouth. The entity labeled TMD actually consists of three identifiable conditions that, at this stage, would be best studied as separate, if not independently occurring, conditions (i.e., given our current state of epidemiologic knowledge about these conditions, it would be most informative to treat them as separate conditions until evidence suggested otherwise). As defined by the group, the three conditions comprising TMD are intemal disk derangement disorder (IDDD), degenerative TMJ disease (DTMJD), and myofascial dysfunction (MD). The "umbrella classification term" of TMD is considered useful much in the manner that the term "low-back pain" has proven useful in the classification of subconditions of that clinical entity. It would be critical to articulate the relationship between each of these conditions and the clinical condition of headache, i.e., to clarify the degree to which "having a headache" is a secondary symptom of one of the above-listed conditions, as distinguished from a separate primary diagnostic condition called headache. The most urgent problem associated with studying the three TMD conditions is the lack of a utilitarian, universally accepted case-definition for each of these conditions. Developing case-definitions is considered to be the highest priority if there is to be any progress made in this area of research, regardless of whether the intent of the investigation is prevalence in descriptive epidemiologic studies, risk factors in analytical epidemiologic studies, or evaluating therapeutic outcome in experimental epidemiologic studies, i.e., clinical trials. A major problem concerns the best method for devel-
Successful resection of a giant recurrent gastrointestinal stromal tumour with imatinib mesylate as neoadjuvant therapy

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the GI tract. Although a great deal of experience has been obtained with imatinib mesylate in patients with unresectable or metastatic GISTs, its role in the neoadjuvant setting is not well established. In this paper, we describe a case of successful resection of a giant recurrent GIST with imatinib mesylate as neoadjuvant therapy.
Aspergillus fumigatus , a saprotrophic pathogenic fungus

Aspergillus fumigatus is the most common and life-threatening aerial fungal pathogen, especially among immuno-compromised hosts. Understanding the pathobiology of this pathogen requires investigations both to characterise the immunosuppressive status of the phagocytic cells that usually kill the fungus in the immunocompetent host, and to identify fungal virulence factors that either promote the resistance of conidia to innate immunity or stimulate mycelial growth in the lung parenchyma. Recent findings are presented in this review and show how little we know of the interactions between host and pathogen. Now the genome of A. fumigatus has been sequenced, tran-scriptome/proteome-based studies should disclose the multiple facets of A. fumigatus pathogenicity.
Neurologic Disability: A Hidden Epidemic for India

India, the world’s second most populous country, is facing the emergence of a hitherto “hidden” epidemic: neurologic disability. The rapid economic, demographic, and social transformation of India in recent decades has already resulted in the double burden of unresolved epidemics of infectious diseases (e.g., malaria, tuberculosis) coupled with rising rates of chronic diseases (e.g., cardiovascular diseases). Neurologic disability is likely to join these public health concerns as a third epidemic, largely due to 3 emerging health trends: 1) an increase in traumatic brain injuries (TBI) from road traffic accidents (RTA); 2) an increase in the incidence of age-related dementia; and 3) an increase in the stroke incidence. Without adequate preparation, the treatment and long-term care for an increasing population of neurologically disabled people will strain India's health care system and economy in the coming years in unprecedented ways.
Sequential test generation based on real-valued logic simulation

This work presents an approach to the test generation for synchronous sequential circuits. This approach utilizes an extended logic simulation, called real-valued logic simulation, and solves the sequential test generation problem as a kind of optimization problem. The approach has the possibility of high speed test generation, because high speed processing techniques, such as, vector processing, parallel processing, and so on, can be efficiently applied to the most time-consuming part of this approach. Experimental results for ISCAS'89 benchmark sequential circuits also illustrate the eficiency of this approach.
The validity of dietary assessment in general practice.

OBJECTIVE: To validate a range of dietary assessment instruments in general practice. METHODS: Using a randomised block design, brief assessment instruments and more complex conventional dietary assessment tools were compared with an accepted "relative" standard--a seven day weighed dietary record. The standard was checked using biomarkers, and by performing test-retest reliability in additional subjects (n = 29). OUTCOMES: Agreement with weighed record. Percentage agreement with weighed record, rank correlation from scatter plot, rank correlation from Bland-Altman plot. Reliability of the weighed record. SETTING: Practice nurse treatment room in a single suburban general practice. SUBJECTS: Patients with risk factors for cardiovascular disease (n = 61) or age/sex stratified general population group (n = 50). RESULTS: Brief self completion dietary assessment tools based on food groups caten during a week show reasonable agreement with the relative standard. For % energy from fat and saturated fat, non-starch polysaccharide, grams of fruit and vegetables and starchy foods consumed the range of agreement with the standard was: median % difference -6% to 12%, rank correlation 0.5 to 0.6. This agreement is of a similar order to the reliability of the weighed record, as good as or better than test standard agreement for more time consuming instruments, and compares favourably with research instruments validated in other settings. Under-reporting of energy intake was common (40%) and more likely if subjects were obese (body mass idex (BMI) > or = 30 60% under-reported; BMI < 30 29%, p < 0.001). CONCLUSION: Under-reporting of absolute energy intake is common, particularly among obese patients. Simple self assessment tools based on food groups, designed for practice nurse dietary assessment, show acceptable agreement with a standard, and suggest such tools are sufficiently accurate for clinical work, research, and possibly population dietary monitoring.