Miracle-dz/UniFAR-FTUs huggingface dataset:
Diet after Stroke and Its Impact on the Components of Body Mass and Functional Fitness—A 4-Month Observation

The aim of the study was to assess the effect of various diets on BMI and selected components of body mass, i.e., fat mass (FAT%), visceral fat (VFAT level), muscle mass (PMM %), body water (TBW %), and functional fitness during a 4-month observation period. Examinations were conducted three times in a group of 100 people after a stroke. The study group was divided into four subgroups according to the type of diet applied. The components of body mass were assessed using the electrical bioimpedance method, and functional fitness using the Barthel scale, the Brunnström scale, and the modified Ashworth scale. Despite the fact that there were no significant differences among the diets applied, it was observed that each of them had a positive effect on the reduction of the mean BMI, FAT%, VFAT level, and the increase in TBW% and PMM%. At the same time, there was a significant improvement in the functional fitness of the hand and upper limb. Weight control and a change in eating habits after a stroke incident is extremely important as it promotes faster recovery and improved functional fitness.
High electron and hole mobility enhancements in thin-body strained Si/strained SiGe/strained Si heterostructures on insulator

Fully depleted MOSFETs were fabricated on strained Si/strained SiGe (46% Ge)/strained Si heterostructures on insulator (HOI) for the first time, demonstrating both high electron and hole mobility enhancements while maintaining excellent subthreshold characteristics. The total thickness of the heterostructure on insulator is less than 25 nm. At an inversion charge density of 1.5/spl times/10/sup 13/ cm/sup -2/, mobility enhancements of 90% and 107% are obtained for electrons and holes respectively. The mobility increases as the cap thickness is reduced to 2 nm. HOI offers superior hole mobility than 40% strained silicon directly on insulator at all vertical fields, when the cap thickness is below 5 nm.
Characterization of a G-protein-regulated outward K+ current in mesophyll cells of vicia faba L.

Whole-cell voltage-dependent currents in isolated mesophyll protoplasts of Vicia faba were investigated by patch-clamp techniques. With 104 mM K+ in the cytosol and 13 mM K+ in the external solution, depolarization of the plasma membrane from -47 mV to potentials between -15 and +85 mV activated a voltage- and time-dependent outward current (Iout). The average magnitude of Iout at +85 mV was 28.5 +/- 3.3 pA.pF-1. No inward voltage-dependent current was observed upon hyperpolarization of the plasma membrane from -55 mV to potentials as negative as -175 mV. Time-activated outward current was blocked by Ba2+ (1 mM BaCl2) and was not observed when K+ was eliminated from the external and internal solutions, indicating that this outward current was carried primarily by K+ ions. The voltage dependency of outward K+ current revealed a possible mechanism for K+ efflux from mesophyll cells. A GDP analogue guanosine 5'-[beta-thio]diphosphate (500 microM) significantly enhanced outward K+ current. The outward K+ current was inhibited by the GTP analogue guanosine 5'-[gamma-thio]triphosphate (500 microM) and by an increase in cytoplasmic free Ca2+ concentrations. Cholera toxin, which ADP-ribosylates guanine nucleotide-binding regulatory proteins, also inhibited outward K+ current. These findings illustrate the presence in mesophyll cells of outward-rectifying K+ channels that are regulated by GTP-binding proteins and calcium.
The Arabidopsis non‐host defence‐associated coumarin scopoletin protects soybean from Asian soybean rust

Summary The fungus Phakopsora pachyrhizi (Pp) causes Asian soybean rust (SBR) disease which provokes tremendous losses in global soybean production. Pp is mainly controlled with synthetic fungicides to which the fungus swiftly develops fungicide resistance. To substitute or complement synthetic fungicides in Asian soybean rust control, we aimed to identify antifungal metabolites in Arabidopsis which is not a host for Pp. Comparative transcriptional and metabolic profiling of the Pp‐inoculated Arabidopsis non‐host and the soybean host revealed induction of phenylpropanoid metabolism‐associated genes in both species but activation of scopoletin biosynthesis only in the resistant non‐host. Scopoletin is a coumarin and an antioxidant. In vitro experiments disclosed fungistatic activity of scopoletin against Pp, associated with reduced accumulation of reactive oxygen species (ROS) in fungal pre‐infection structures. Non‐antioxidant and antioxidant molecules including coumarins with a similar structure to scopoletin were inactive or much less effective at inhibiting fungal accumulation of ROS and germination of Pp spores. When sprayed onto Arabidopsis leaves, scopoletin also suppressed the formation of Pp pre‐infection structures and penetration of the plant. However, scopoletin neither directly activated defence nor did it prime Arabidopsis for enhanced defence, therefore emphasizing fungistatic activity as the exclusive mode of action of scopoletin against Pp. Because scopletin also protected soybean from Pp infection, the coumarin may serve as a natural fungicide or as a lead for the development of near‐to‐nature fungicides against Asian soybean rust.
Inorganic Polyphosphate Regulates AMPA and NMDA Receptors and Protects Against Glutamate Excitotoxicity via Activation of P2Y Receptors

Glutamate is one of the most important neurotransmitters in the process of signal transduction in the CNS. Excessive amounts of this neurotransmitter lead to glutamate excitotoxicity, which is accountable for neuronal death in acute neurological disorders, including stroke and trauma, and in neurodegenerative diseases. Inorganic polyphosphate (PolyP) plays multiple roles in the mammalian brain, including function as a calcium-dependent gliotransmitter mediating communication between astrocytes, while its role in the regulation of neuronal activity is unknown. Here we studied the effect of PolyP on glutamate-induced calcium signal in primary rat neurons in both physiological and pathological conditions. We found that preincubation of primary neurons with PolyP reduced glutamate-induced and AMPA-induced but not the NMDA-induced calcium signal. However, in rat hippocampal acute slices, PolyP reduced ion flux through NMDA and AMPA receptors in native neurons. The effect of PolyP on glutamate and specifically on the AMPA receptors was dependent on the presence of P2Y1 but not of P2X receptor inhibitors and also could be mimicked by P2Y1 agonist 2MeSADP. Preincubation of cortical neurons with PolyP significantly reduced the initial calcium peak as well as the number of neurons with delayed calcium deregulation in response to high concentrations of glutamate and resulted in protection of neurons against glutamate-induced cell death. As a result, activation of P2Y1 receptors by PolyP reduced calcium signal acting through AMPA receptors, thus protecting neurons against glutamate excitotoxicity by reduction of the calcium overload and restoration of mitochondrial function. SIGNIFICANCE STATEMENT One of the oldest polymers in the evolution of living matter is the inorganic polyphosphate (PolyP). It is shown to play a role of gliotransmitter in the brain; however, the role of polyphosphate in neuronal signaling is not clear. Here we demonstrate that inorganic polyphosphate is able to reduce calcium signaling induced by physiological or high concentrations of glutamate. The effect of polyphosphate on glutamate-induced calcium signal in neurons is due to the effect of this polymer on the AMPA receptors. The effect of PolyP on glutamate-induced and AMPA-induced calcium signal is dependent on P2Y receptor antagonist. The ability of PolyP to restrict the glutamate-induced calcium signal lies in the basis of its protection of neurons against glutamate excitotoxicity.
PDMS-Infused Poly(High Internal Phase Emulsion) Templates for the Construction of Slippery Liquid-Infused Porous Surfaces with Self-cleaning and Self-repairing Properties.

Advanced liquid-repelling materials that resist both water-based and oil-based contaminants have significant applications in many fields. Herein, a novel protocol for the fabrication of a robust poly(high internal phase emulsion) (polyHIPE)-based slippery liquid-infused porous surface (SLIPS) system with combined self-repairing and self-cleaning properties is developed. Specifically, polystyrene-based polyHIPE (PS-HIPE) membranes with an interconnected porous structure were prepared from polymerization of the continuous oil phase in the water-in-oil HIPE templates. These polyHIPE membranes were used, for the first time, as porous substrates for loading low surface tension silicone oils as lubricating liquids for the fabrication of polyHIPE-based SLIPS membranes. These polyHIPE-based SLIPS membranes could easily repel both water- and oil-based contaminants (e.g., ink, milk, and coffee) with very low sliding angles (3.0 ± 1.3°) and could even repel solid contaminants (e.g., dust) upon washing with water. Meanwhile, such membranes exhibit excellent self-repairing properties so that physical scratching damage, such as cutting a trench, does not affect the liquid-repelling performance. The liquid-repelling ability could be recovered completely within 10 s. More significantly, such a SLIPS membrane shows excellent durability so that the water sliding angle of the SLIPS could be maintained at less than 5.0° for about 80 cycles owing to the regenerated poly(dimethylsiloxane) layer on the surface. This work represents a robust methodology to enrich the development of hydrophobic and oleophobic slippery surfaces, which is promising for many areas, such as biomedical, self-cleaning, antifouling, and self-repairing materials.
LnCompare: gene set feature analysis for human long non-coding RNAs

Abstract Interest in the biological roles of long noncoding RNAs (lncRNAs) has resulted in growing numbers of studies that produce large sets of candidate genes, for example, differentially expressed between two conditions. For sets of protein-coding genes, ontology and pathway analyses are powerful tools for generating new insights from statistical enrichment of gene features. Here we present the LnCompare web server, an equivalent resource for studying the properties of lncRNA gene sets. The Gene Set Feature Comparison mode tests for enrichment amongst a panel of quantitative and categorical features, spanning gene structure, evolutionary conservation, expression, subcellular localization, repetitive sequences and disease association. Moreover, in Similar Gene Identification mode, users may identify other lncRNAs by similarity across a defined range of features. Comprehensive results may be downloaded in tabular and graphical formats, in addition to the entire feature resource. LnCompare will empower researchers to extract useful hypotheses and candidates from lncRNA gene sets.
Harmonic elimination control of an inverter based on an artificial neural network strategy

Abstract Abstract A neural implementation of a harmonic elimination strategy for the control a uniform step asymmetrical 11-level inverter is proposed and described in this paper. A Multi-Layer Perceptrons (MLP) neural network is used to approximate the mapping between the modulation rate and the required switching angles. After learning, the neural network generates the appropriate switching angles for the inverter. This leads to a low-computational-cost neural controller which is therefore well suited for real-time applications. This neural approach is compared to the well-known sinusoidal Pulse-Width Modulation (PWM). Simulation results demonstrate the technical advantages of the neural implementation of the harmonic elimination strategy over the conventional method for the control of an uniform step asymmetrical 11-level inverter. The approach is used to supply an asynchronous machine and results show that the neural method ensures a highest quality torque by efficiently canceling the harmonics generated by the inverter.
Draft Genome Sequence of Pseudomonas sp. Strain M7D1, Isolated from the Rhizosphere of Desert Bloom Plants

We announce the draft genome sequence of Pseudomonas sp. strain M7D1, isolated from the rhizosphere of a plant in the Atacama Desert bloom event. The genome sequence had 6,170,633 bp with a G+C content of 59.9%. ABSTRACT We announce the draft genome sequence of Pseudomonas sp. strain M7D1, isolated from the rhizosphere of a plant in the Atacama Desert bloom event. The genome sequence had 6,170,633 bp with a G+C content of 59.9%. This draft genome sequence gives information about the presence of genes related to iron acquisition, alleviation of abiotic stress, and other essential traits of plant growth-promoting rhizobacteria.
Geometric and Electronic Structure Contributions to O-O Cleavage and the Resultant Intermediate Generated in Heme-Copper Oxidases.

This study investigates the mechanism of O-O bond cleavage in heme-copper oxidase (HCO) enzymes, combining experimental and computational insights from enzyme intermediates and synthetic models. It is determined that HCOs undergo a proton-initiated O-O cleavage mechanism where a single water molecule in the active site enables proton transfer (PT) from the cross-linked tyrosine to a peroxo ligand bridging the heme FeIII and CuII, and multiple H-bonding interactions lower the tyrosine pKa. Due to sterics within the active site, the proton must either transfer initially to the O(Fe) (a high-energy intermediate), or from another residue over a ~10 Å distance to reach the O(Cu) atom directly. While the distance between the H+ donor (Tyr) and acceptor (O(Cu)) results in a barrier to PT, this separation is critical for the low barrier to O-O cleavage as it enhances backbonding from Fe into the O-O σ* orbital. Thus, PT from Tyr precedes O-O elongation and is rate-limiting, consistent with available kinetic data. The electron transfers from tyrosinate after the barrier via a superexchange pathway provided by the cross-link, generating intermediate PM. PM is evaluated using available experimental data. The geometric structure contains an FeIV=O that is H-bonded to the CuII-OH. The electronic structure is a singlet, where the FeIV and CuII are antiferromagnetically coupled through the H-bond between the oxo(Fe) and hydroxo(Cu) ligands, while the CuII and Tyr● are ferromagnetically coupled due their delocalization into orthogonal magnetic orbitals on the cross-linked His residue. These findings provide critical insights into the mechanism of efficient O2 reduction in HCOs, and the nature of the PM intermediate that couples this reaction to proton pumping.
Similarity measure determination from NURBS-warping method

In this paper, we propose a new similarity measure determination based on the NURBS-Warping method. In this method, the query image represented by the Non-Uniform Rational B-Spline (NURBS) descriptor is warped to best fit the shape of the database image. The similarity between two images is determined by measuring the effort being spent in the warping process. Four similarity parameters are derived to reflect the effort spent throughout the warping process. These parameters are the Total Cumulative Change in the Position of the Control Points (TCCPCP), Total Cumulative Change in the Curvature of the Control Points (TCCCCP), Total Cumulative Voting Distance Score (TCVDS) and degree of matching, which are used to compute the similarity measure for each database image. The retrieved database images are ranked according to the computed similarity measure. A set of experiments is carried out to investigate the characteristic of each similarity parameters that influence the similarity measure computation independently. We also validate the effectiveness of the computed similarity measure for retrieving a set of database images based on the human similarity judgement. The retrieval results of the proposed method are compared with the Curvature Scale Space (CSS) method proposed by Mokhtarian. The overall experiments results show that the similarity measure derived from the NURBS-Warping method show good retrieval results in a highly similar database.
High NPM1 mutant allele burden at diagnosis correlates with minimal residual disease at first remission in de novo acute myeloid leukemia

Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 WHO classification, and is associated with a favorable prognosis. While previous studies have evaluated NPM1 in a binary fashion, we recently demonstrated a significant independent negative prognostic effect of high NPM1 mutant allele burden (VAF) at diagnosis in a cohort of de novo AML patients. Although the importance of minimal residual disease (MRD) monitoring in NPM1‐mutated AML has been well characterized, the potential relationship between diagnostic allele burden and MRD is unknown. We retrospectively evaluated for MRD at first remission (CR1). We used either next‐generation sequencing (NGS) [n = 71], and/or immunohistochemistry (IHC) for mutant NPM1 (NPM1c) [n = 60], in a subset of patients from our recently examined cohort. We identified a statistically significant positive correlation between the VAF at diagnosis, and at CR1 (Spearman r = 0.4, P = .006), and enrichment for MRD in high diagnostic VAF patients (P = .05), as previously defined. IHC‐positivity also correlated significantly with a higher median diagnostic NPM1 VAF (0.42 vs 0.39, P = .02), and with the VAF at CR1 (Spearman r = 0.7, P = .003). In multivariable analyses, both high diagnostic VAF (P = .003) and MRD (P = .02) were independent predictors of shorter event‐free survival (EFS). Our findings suggest a relationship between the NPM1 mutant allele burden at diagnosis, and the presence of MRD at first remission. Our findings support IHC as a potentially useful adjunctive tool for disease monitoring.
Brachial plexus injuries and shoulder dystocia: Medico-legal commentary and implications

Brachial plexus injuries may occur in association with or without recognised shoulder dystocia. Until recently many medico-legal experts argued that these injuries resulted from the negligent use of excessive or misdirected traction. These experts did not accept that the natural forces of labour could cause the injury. In cases of recognised shoulder dystocia, modern obstetric practice has recognised the importance of correct maternal positioning and the need to avoid excessive or misdirected traction, also the importance of not applying a rotational force to the fetal head. Informed practice and the increased use of caesarean section has not reduced the number of brachial plexus injuries. Judges in two recent trials found that the natural forces of labour were the cause of the injury and that the birth assistants had not caused the damage. This has important implications for medical note writing, teachers and risk managers, medico-legal experts and lawyers.
Transmembrane helix-helix interactions involved in ErbB receptor signaling

Among the many transmembrane receptor classes, the receptor tyrosine kinases represent an important superfamily, involved in many cellular processes like embryogenesis, development and cell division. Deregulation and dysfunctions of these receptors can lead to various forms of cancer and other diseases. Mostly, only fragmented knowledge exists about functioning of the whole receptors, and many studies have been performed on isolated receptor domains. In this review we focus on the function of the ErbB family of receptor tyrosine kinases with a special emphasis on the role of the transmembrane domain and on the mechanisms underlying regulated and deregulated signaling. Many general aspects of ErbB receptor structure and function have been analyzed and described. All human ErbBs appear to form homo- and heterodimers within cellular membranes and the single transmembrane domain of the receptors is involved in dimerization. Additionally, only defined structures of the transmembrane helix dimer allows signaling of ErbB receptors.
E-Training Acceptance Factors in Business Organizations

E-training is considered nowadays as a very important issue for business organization because of the benefits it can bring. Unfortunately, e-training is not fit well in most of Jordanian organization. In order to implement e-training successfully in an organization, you need the right people at the right place using the right resources. Furthermore, it is essential to measure the organizationâ? s acceptance for the new e-training system before implementing it in order to gain its full potential. This research proposes a model to measure an organizationâ? s acceptance for a new e-training system. This model has been developed from various previous studies and then it has been tested using quantitative methods (Questionnaire). The studied factors which are believed to affect the e-training acceptance are: System Functionality, Finance Resources and Human capabilities.
In‐Season Functional Shoulder Training for High School Baseball Pitchers

summary The overhead throwing motion is used in numerous sports including track, football, and baseball. Among these sports, the baseball pitch is unique in the demands placed upon the shoulder. The forces created in the shoulder can potentially lead to pathology affecting the athlete's career. To enhance performance and decrease the risk of injury, it is important that the athlete participate in a year-round periodized program. Inappropriate or deficient training combined with the stress that the shoulder experiences during a season can lead to strains, impingement, tendon or labral tears, and instabilities.
FSO Communication capacity in turbulent and dispersive channel with AWGN noise

In this paper, we have investigated the FSO communication capacity in the presence of the temporal pulse broadening effect which caused by the group velocity dispersion and atmospheric turbulence. We have modeled the pulse propagation in atmospheric turbulence and chromatic dispersion by using the two-frequency mutual coherence function (MCF). By using the Shannon-Hartly theorem, we have derived an analytical expression for signal to noise ratio of the propagating Gaussian pulse in dispersive and turbulent atmospheric channel. The results shows that the capacity communication degrades drastically under the temporal pulse broadening effect. The degradation is very important for a longer distance. By increasing the power of the transmitted signal, and choosing the appropriate transceiver altitude, we can minimize the pulse-broadening effect on FSO capacity.