Miracle-dz/UniFAR-FTUs huggingface dataset:
Money Demand Stability and Inflation Prediction in the Four Largest EMU Countries

In this paper, we analyze the money demand functions of the four largest EMU countries and of the four-country (EMU-4) aggregate. We identify reasonable and stable money demand relationships for Germany, France and Spain as well as the EMU-4 aggregate. For the case of Italy, results are less clear. From the estimated money demand functions, we derive both EMU-4 and country-specific measures of money overhang. We find that the EMU-4 overhang measure strongly correlates with the country-specific measures, particularly since the start of EMU, and is useful to predict country-specific inflation. However, it generally does not encompass country-specific money overhang measures as predictors of inflation. Hence, aggregate money overhang is an important, but by far not an exhaustive, indicator for the disaggregate level.
Coproprevalencia de infestación canina por Echinococcus granulosus en un distrito endémico en hidatidosis en Perú

El objetivo del estudio fue determinar la coproprevalencia de Equinococcus granulosus en canes del distrito rural de San Jose de Queros, ubicado en la provincia de Concepcion, region Junin, en el centro del Peru. El estudio fue observacional de tipo transversal, y se llevo a cabo en 2015 en los tres anexos del distrito. Se recolectaron muestras de heces de 152 canes del mismo numero de hogares seleccionados al azar y se procesaron mediante la tecnica de ELISA especifica de Echinococcus granulosus. El 50% (Usibamba 61.0%, Chaquicocha 51.0% y San Jose de Quero 41.9%) de muestras fueron positivas al parasito. Asimismo, se determino que el promedio de canes por casa fue 2.3, el 40.9% de los duenos alimentaba a los canes con visceras frescas del ganado sacrificado, la proporcion de perros que defecan fuera de casa era de 91.3%, y que el 18.4% refiere haber tenido algun familiar con quiste hidatidico. Se concluye que la infestacion canina por E. granulosus es frecuente en el distrito San Jose de Quero, la cual es facilitada por los habitos de los duenos y los comportamientos epidemiologicos del can.
Improving Weight of Evidence Approaches to Chemical Evaluations

Federal and other regulatory agencies often use or claim to use a weight of evidence (WoE) approach in chemical evaluation. Their approaches to the use of WoE, however, differ significantly, rely heavily on subjective professional judgment, and merit improvement. We review uses of WoE approaches in key articles in the peer‐reviewed scientific literature, and find significant variations. We find that a hypothesis‐based WoE approach, developed by Lorenz Rhomberg et al., can provide a stronger scientific basis for chemical assessment while improving transparency and preserving the appropriate scope of professional judgment. Their approach, while still evolving, relies on the explicit specification of the hypothesized basis for using the information at hand to infer the ability of an agent to cause human health impacts or, more broadly, affect other endpoints of concern. We describe and endorse such a hypothesis‐based WoE approach to chemical evaluation.
Heterovalent‐Doping‐Enabled Efficient Dopant Luminescence and Controllable Electronic Impurity Via a New Strategy of Preparing II−VI Nanocrystals

Substitutional heterovalent doping represents an effective method to control the optical and electronic properties of nanocrystals (NCs). Highly monodisperse II-VI NCs with deep substitutional dopants are presented. The NCs exhibit stable, dominant, and strong dopant fluorescence, and control over n- and p-type electronic impurities is achieved. Large-scale, bottom-up superlattices of the NCs will speed up their application in electronic devices.
Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial.

PURPOSE To determine whether shortening the infusion duration of high-dose methotrexate (HDMTX; 1 g/m(2)) affects the in vivo accumulation of active methotrexate polyglutamates (MTXPG(1-7)) in leukemia cells and whether this differs among major acute lymphoblastic leukemia (ALL) subtypes. METHODS From June 2000 through October 2007, 356 children with ALL were randomly assigned to receive initial single-agent treatment with HDMTX (1 g/m(2)) as either a 24-hour infusion or a 4-hour infusion at two pediatric hospitals in the United States. The primary outcome measures were the accumulation of MTXPG(1-7) in leukemia cells and the antileukemic effects (eg, inhibition of de novo purine synthesis in bone marrow ALL cells, and decrease in circulating ALL cells). RESULTS The 24-hour infusion resulted in significantly higher amounts of MTXPG(1-7) in bone marrow leukemia cells (median: 1,695 v 1,150 pmol/10(9) cells, P = . 0059), and better antileukemic effects. The 24-hour infusion had the greatest effect on MTXPG(1-7) accumulation in hyperdiploid ALL (median: 3,919 v 2,417 pmol/10(9) cells, P = . 0038); T-cell ALL exhibited smaller differences in MTXPG(1-7) but greater antileukemic effects with the longer infusion (median decrease in leukemia cells: 88.4% v 51.8%, P = .0075). In contrast, infusion duration had no significant impact on MTXPG(1-7) accumulation or antileukemic effects in ALL with the t(12;21)/(ETV6-RUNX1) chromosomal translocation. CONCLUSION Shortening the infusion time of HDMTX reduces accumulation of active methotrexate in leukemia cells and decreases antileukemic effects, with differing consequences among major ALL subtypes.
Inhibitory effect of cerulenin and sodium butyrate on germination of Candida albicans

Candida albicans germination in liquid medium was inhibition by the antilipogenic agent cerulenin and the fatty acid sodium butyrate. Although these inhibitors prevented germ tube emergence at concentrations of 1 microgram/ml and 20 mM, respectively, neither significantly affected cell viability as judged by trypan blue staining or the rate of protein biosynthesis throughout the time course of the experiments. Cerulenin treatment resulted in inhibition of lipid biosynthesis, but lipid biosynthetic capabilities remained unaltered in sodium butyrate-supplemented cultures. Because each inhibitor blocks germination by different mechanisms, their utility in distinguishing events directly correlated to germination was examined. In this context, chitin synthase activity was inhibited by both compounds, confirming the importance of chitin biosynthesis in C. albicans germination.
Violations of Listing's law after large eye and head gaze shifts.

1. Kinematic constraints were examined in static eye and head positions after large gaze shifts to visual targets. Three-dimensional eye and head rotations were measured in six adult human subjects by the use of the magnetic field search coil technique. 2. Eye positions in space were found to obey Donder's law; i.e., for any given gaze direction there was a unique three-dimensional orientation. In other words, angular eye positions in space (expressed as quaternions) were constrained to a two-dimensional surface. 3. When only the eye moved (head stationary), the shape of this surface resembled a plane and thus the eye position in space obeyed Listing's law. However, after gaze shifts involving both the eye and the head, the eye in space surface became twisted and thus nonplanar. This twist was similar to that achieved by a Fick gimbal model of rotations in which the horizontal axis is nested within a fixed vertical axis. During oblique gaze shifts, the head made predominantly horizontal movements whereas the eye made predominantly vertical movements. This, combined with the fact that the eye is mounted within the head, causes the eye in space surface to resemble that of a Fick gimbal. 4. The angular position of the head in space was also constrained to a two-dimensional surface. This surface was also not planar (Listinglike) and twisted in a manner similar to that of the eye in space. 5. Whereas the angular position of the eye in head was found to obey Listing's law after head-fixed gaze shifts, violations of Listing's law occurred after head-free gaze shifts. These violations showed significant intersubject variation in their magnitude and character. 6. Given that the eye in space violates Listing's law after head movements, the supposition that Listing's law serves the perceptual purpose of maintaining radial constancy is untenable. The Fick gimballike behavior of the head in space and eye in space may hold several advantages over a Listing's system. When the head in space behaves like a Fick gimbal, a horizontal line through the eyes remains parallel to the horizon. By having the eye in space behave like a Fick gimbal, the work done against gravity may be minimized by having the eye contribute more to vertical gaze shifts than does the head.
Prevalence of Cryptococcus neoformans in pigeon habitats.

THE frequent occurrence of virulent strains of Cryptococcus neoformans in pigeon droppings under roosting sites and in old pigeon nests was first reported in 1955 (1). Prompt confirmation of this observation from Japan (£), Cincinnati, Ohio (3)9 and New York City (4) showed that this is not an un¬ usual or geographically restricted association. The pigeon is not a host to C. neoformans but this pathogenic fungus grows as a saprophyte in pigeon manure and can be isolated from the majority of specimens collected in either rural or urban areas. I have continued investigations of the preva¬ lence of C. neoformans in the environment in order to estimate the frequency of man's possi¬ ble exposure to the fungus and to evaluate in retrospect the accuracy of diagnoses in certain epidemics or focal outbreaks of pneumonitis which have been accepted as histoplasmosis.
Low-Complexity Finger-Wise Interference Cancellation for Rake Receivers with Receive Diversity

Today's mobile communications systems are usually interference limited in terms of their overall capacity. In the paper we present a novel powerful yet simple interference cancellation algorithm for receive diversity systems. The algorithm for Rake receivers is based on the correlation between the identical multi-path delays occurring on the antennas. The attractive simplicity is due to the separate handling of different Rake fingers yielding a low complexity with the lack of large matrices. Nevertheless, the new algorithm exhibits an excellence performance, which is proven by simulation results.
An accurate and efficient monocular mixed match SLAM

This paper proposed a Mixed Match SLAM embedded with two match methods, planar patch based and visual descriptor based. Planar patch based method eliminates the cost of feature extraction for motion estimation. Visual descriptor based method is more robust for wide baseline match and loop closing. We use a reasonable statistic criterion to determine keyframe for redundancy avoidance. An efficient outlier detection method is employed to pick out feature match outliers trapped in local minimum. Quantitative comparison experiments with the state-of-the-art ORB-SLAM2 show that the proposed method achieves better performance in large region dynamic scenes due to a less redundant keyframe network. It also provides better performance than ORB-SLAM2 in most static benchmark scenes with higher efficiency.
Hope, Hopelessness, and Suicidality in College Students

To estimate the associations among measures of hope, hopelessness, and suicidality, 206 undergraduates completed the Reasons for Living Inventory, the Hopelessness Scale, and the Hope Scale. As expected, significant correlations indicated that, as hope increased, hopelessness decreased. Those who scored as relatively more suicidal had relatively fewer feelings of total hope (Agency and Pathways) and more hopelessness. Further, scores on three Reasons for Living scales (Coping Beliefs, Family Responsibility, and Child Concerns) were significantly correlated in expected directions with hope and hopelessness scores. A stepwise multiple regression indicated that scores on Survival, Coping Beliefs and the Hope subscale Agency accounted for 37% of the total variance in suicidality. Apparently in unscreened college students, survival and coping beliefs and hope rather than hopelessness or other reasons for living are most related to suicidality. An implication is that facilitating college students' hopefulness may bolster their survival and coping beliefs and discourage development of suicidal thoughts or actions.
The organophosphate‐induced acute‐phase response is characterized by synthesis of α1‐acid glycoprotein that exhibits an immunomodulatory effect

The organophosphorus compounds soman and paraoxon induce the acute‐phase (AP) response. All phases of the AP response, from macrophage activation and stimulation of glucocorticoid secretion to AP protein expression appear to be under the control of similar molecular mechanisms to those during the turpentine‐induced AP response. The AP protein content in the circulation 24 h after either soman, paraoxon or turpentine administration was injury‐specific. Both soman and paraoxon poisoning were characterized by significantly increased synthesis of α1‐acid glycoprotein (AGP) that displayed an immunomodulatory effect in vitro. This result suggests that after organophosphate poisoning AGP participates in vivo in a negative feedback mechanism that prevents over‐activity of the immune system. Copyright © 2007 John Wiley & Sons, Ltd.
Integrated modeling and intelligent control methods of grinding process

The grinding industrial production system is a typical complex nonlinear multivariable process with strongly coupling and large time delays. The up-to-the-minute research results of integrated modeling and intelligent control of grinding process are summarized. It mainly includes the fuzzy control, artificial neural network control, soft-sensor modeling and hybrid intelligent control strategy. In the end the future research directions in the grinding process control field is concluded.
Advances in smart wheelchair technology

A Survey of Disabled Persons by NSSO (2011) reported that Disability is an important public health problem in India. The wheelchair is topmost used assistive devices for enhancing the personal mobility of disabled people. Power wheelchairs are useful for those unable to propel a manual wheelchair. The disabled people with visual acuity, lack of motor skills and strength find difficult to use a power wheelchair. To solve this problem, several researchers have used mobile robots technologies to create smart wheelchairs. A smart wheelchair typically contains a standard power wheelchair, a computer and a collection of sensors. The recent development in research areas such as computer science, robotics, Artificial Intelligence and sensor technology broaden the range of features in smart wheelchairs. This paper presents designs of different prototypes of smart wheelchairs proposed by researchers. Future research challenges in this field are recognized. Also, Directions for upcoming research are discussed.
Generation of Infectious Pancreatic Necrosis Virus from Cloned cDNA

ABSTRACT We developed a reverse genetics system for infectious pancreatic necrosis virus (IPNV), a prototype virus of theBirnaviridae family, with the use of plus-stranded RNA transcripts derived from cloned cDNA. Full-length cDNA clones of the IPNV genome that contained the entire coding and noncoding regions of RNA segments A and B were constructed. Segment A encodes a 106-kDa precursor protein which is cleaved to yield mature VP2, nonstructural protease, and VP3 proteins, whereas segment B encodes the RNA-dependent RNA polymerase VP1. Plus-sense RNA transcripts of both segments were prepared by in vitro transcription of linearized plasmids with T7 RNA polymerase. Transfection of chinook salmon embryo (CHSE) cells with combined transcripts of segments A and B generated infectious IPNV particles 10 days posttransfection. Furthermore, a transfectant virus containing a genetically tagged sequence was generated to confirm the feasibility of this system. The presence and specificity of the recovered virus were ascertained by immunofluorescence staining of infected CHSE cells with rabbit anti-IPNV serum and by nucleotide sequence analysis. In addition, 3′-terminal sequence analysis of RNA from the recovered virus showed that extraneous nucleotides synthesized at the 3′ end during in vitro transcription were precisely trimmed or excluded during replication, and hence these were not incorporated into the genome. An attempt was made to determine if RNA-dependent RNA polymerase of IPNV and infectious bursal disease virus (IBDV), another birnavirus, can support virus rescue in heterologous combinations. Thus, CHSE cells were transfected with transcripts derived from IPNV segment A and IBDV segment B and Vero cells were transfected with transcripts derived from IBDV segment A and IPNV segment B. In either case, no infectious IPNV or IBDV particles were generated even after a third passage in cell culture, suggesting that viral RNA-dependent RNA polymerase is species specific. However, the reverse genetics system for IPNV that we developed will greatly facilitate studies of viral replication and pathogenesis and the design of a new generation of live attenuated vaccines.
Visual Clustering and Boundary Detection of Time-Dependent Datasets

Visual clustering should be one of the basic tools for time-dependent data analysis in cyberworlds. This paper describes a novel approach to spatial clustering and boundary detection based on geometric modeling and visualization. Datasets and boundaries of clusters are visualized as 3D points and surfaces of reconstructed solids changing over time. Our approach applies the concepts of geometric solid modeling and uses density as clustering criteria that comes from traditional density-based clustering techniques. Visual clustering allows the user to analyze results of clustering the data changing over time and to interactively choose appropriate parameters.
Évaluation de la fonction β cellulaire par le repas-test chez le diabétique de type 2 : intérêt clinique

Le diabete de type 2 est un probleme de sante publique au niveau mondial. Sa prise en charge therapeutique est basee sur des algorithmes de traitement agence en fonction de parametres cliniques et de l'HbAl C selon le principe du « try and see ». L'evaluation de la fonction beta cellulaire n'est a ce jour pas prise en compte dans l'adaptation des traitements. Le repas test (RT) permet d'evaluer la fonction 13 cellulaire. Ce travail propose d'observer s'il existe une difference de resultats sur les parametres du RT entre les patients insulinotraites et non insulinotraites. Methode : Une etude retrospective a ete menee sur les patients diabetiques de type 2 (DT2) ayant realise un RT entre janvier 2014 et mars 2017. Les patients etaient places dans le groupe Non Insuline (NI) si leur traitement ne comprenait pas d'insuline et dans le groupe Insuline (I) si il existait une insulinotherapie. Lors du RT la glycemie, l'insulinemie, le C-Peptide (CP) et le C-Peptide ratio (CPR) etaient mesures a TO, T60 etT 120. L'HbAl C a ete controlee dans les trois a six mois apres le RT. Resultats : 59 patients ont ete recrutes, 48 dans le groupe NI et 11 dans le groupe I. Les CP et CPR aux trois temps entre les 2 groupes sont statistiquement differents (p Conclusion : Le repas-test permet de differencier les patients DT2 insulinotraites versus non insulinotraites de facon significative. Pour differencier ces deux groupes, les prelevements post prandiaux n'apportent pas davantage de renseignements que les prelevements realises a jeun. Les glycemies des trois temps ainsi que les CPR post prandiaux sont correles a l'equilibre du diabete a moyen terme.
Évaluation de l’utilité et acceptabilité en médecine générale en Haute-Normandie, d’un outil internet d’aide au dépistage et à la prise en charge des troubles du comportement alimentaire, intégrant le questionnaire SCOFF-F

Les troubles du comportement alimentaire (TCA) sont de plus en plus frequents en France, mais restent sous diagnostiques. A partir des definitions diagnostiques du DSM-V, les TCA peuvent etre regroupes pour la pratique courante en TCA restrictifs, boulimiques, compulsifs ou autres (categories larges). OBJECTIF : L'objectif de notre etude a ete de creer un site web integrant le questionnaire de depistage SCOFF-F, un algorithme d'orientation diagnostique des categories larges de TCA (ExpalinA) et des conseils de prise en charge, puis le faire tester par des medecins generalistes sur une patientele ambulatoire. METHODES : Le site a ete propose par mail ou lors d'un entretien a des medecins generalistes liberaux de Haute-Normandie, qui etaient invites a le tester lors de leurs consultations, et a remplir un questionnaire final d'evaluation. L'etude a ete realisee en 2016-2017. RESULTATS : Parmi les medecins sollicites, 34 (31,2%) ont finalement utilise le site ExpalilM et repondu au questionnaire final. ils pensaient recommander le site a un confrere (78%), l'ont trouve « Assez » ou « Tres efficace » (61%), se disaient « Peu » a « Tres » satisfaits des conseils de prise en charge (83%), se disaient satisfaits de le l'ergonomie (95%). Deux medecins sur 3 initialement contactes n'ont finalement pas utilise le site. CONCLUSION : Pour les medecins qui l'ont utilise, le site ExpaliTM semble repondre a leurs attentes en termes d'aide au diagnostic et a la prise en charge des TCA. La motivation des medecins generalistes pour une formation a ce type d'outil reste toutefois limitee par differents facteurs (manque de temps, lacunes en informatique, sous-estimation de l'enjeu lie aux TCA en medecine generale). Au-dela de cette etape de faisabilite, la validation du site doit etre poursuivie.
Silencing and Activation of ClyA Cytotoxin Expression in Escherichia coli

ABSTRACT Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene of Escherichia coli K-12. Genetic analysis suggested that clyA is silenced by the nucleoid protein H-NS. Purified H-NS protein showed preferential binding toclyA sequences in the promoter region, as evidenced by DNase I footprinting and gel mobility shift assays. Transcriptional derepression and activation of a chromosomalclyA::luxAB operon fusion were seen under conditions of H-NS deficiency and SlyA overproduction, respectively. In H-NS-deficient bacteria neither the absence nor the overproduction of SlyA affected the derepressed ClyA expression any further. Therefore, we suggest that overproduction of SlyA inhns+ E. coli derepresses clyAtranscription by counteracting H-NS. The cyclic AMP receptor protein (CRP) was required for ClyA expression, and it interacted with a predicted, albeit suboptimal, CRP binding site in the clyAupstream region. Site-specific alterations of the CRP binding site to match the consensus resulted in substantially higher levels of ClyA expression, while alterations that were predicted to reduce CRP binding reduced ClyA expression. During anaerobic growth the fumarate and nitrate reduction regulator (FNR) was important for ClyA expression, and the clyA gene could be activated by overexpression of FNR. A major clyA transcript having its 5′ end (+1) located 72 bp upstream of the translational start codon and 61 bp downstream of the CRP-FNR binding site was detected in the absence of H-NS. TheclyA promoter was characterized as a class I promoter that could be transcriptionally activated by CRP and/or FNR. According to DNA bending analyses, the clyA promoter region has high intrinsic curvature. We suggest that it represents a regulatory region which is particularly susceptible to H-NS silencing, and its features are discussed in relation to regulation of other silenced operons.