Miracle-dz/UniFAR-FTUs huggingface dataset:
L'industrie atérienne de l'Oued Djouf El Djemel. Comparaison avec l'industrie de l'Oued Djebbana. Le complexe atérien du Maghreb Oriental

Resume. — L'auteur etudie une serie de pieces ateriennes provenant de l'oued Djouf el Djemel dans l'Est algerien. Il s'agit d'une industrie de debitage Levallois, tres riche en pieces pedonculees, pauvre en racloirs, tres pauvre en pointes mousteriennes et en percoirs. La comparaison de cet outillage avec celui de diverses autres stations de la region conduit l'auteur a emettre l'hypothese de l'existence d'un complexe aterien comprenant, d'une part des industries ou les pieces pedonculees sont nombreuses, d'autre part des industries ou elles sont rares.
Infarctus du myocarde chez le sujet âgé

En raison d’une mortalite elevee et du vieillissement croissant de la population, l’infarctus du myocarde du sujet âge est un enjeu de sante publique. Le diagnostic clinique et electrique est plus delicat que chez le sujet jeune : pauvrete des symptomes, electrocardiogramme d’interpretation difficile. Cela explique, que celui-ci est souvent meconnu, ou fait trop tardivement pour permettre un sauvetage myocardique significatif, et de fait les techniques de reperfusion sont sous-utilisees. Cependant, ces techniques de reperfusion, fibrinolyse et/ou angioplastie, doivent etre discutees au cas pour cas pour assurer une reperfusion precoce et durable, meilleur garant de la survie a long terme. De meme, la prise en charge au decours de l’infarctus doit se calquer sur celle effectuer chez le sujet le plus jeune en utilisant les therapeutiques (statines, aspirine, IEC, betabloquants…) fondees sur les preuves. La prise en charge des sujets tres âges doit faire l’objet d’une concertation entre cardiologues et geriatres pour une gestion individualisee.
The Apolipoprotein E &egr;4 Allele Increases the Odds of Chronic Cerebral Infarction Detected at Autopsy in Older Persons

Background and Purpose— Studies investigating the relation of the apolipoprotein E (apoE) &egr;4 allele to clinical stroke and to vascular changes on magnetic resonance imaging have been conflicting. Little data are available regarding the relation of apoE &egr;4 to cerebral infarctions documented on postmortem examination. Methods— We studied the apoE &egr;4 allele in 214 deceased members of the Religious Orders Study, a longitudinal clinical–pathologic study of aging and Alzheimer disease. The apoE genotype was determined using DNA from lymphocytes. Brains were removed a median of 5 hours (interquartile range, 5.5) after death. At postmortem examination, age, location, and size of macroscopic chronic cerebral infarctions were recorded from 1-cm coronal slabs after paraformaldehyde fixation. We also examined 20-&mgr;m paraffin-embedded sections of midfrontal and calcarine cortex for amyloid angiopathy on a scale of 1 to 4. Results— Subjects included 96 males and 118 females with a mean age at death of 86 years (SD, 7). Sixty-five subjects (30.4%) had at least 1 apoE &egr;4 allele and 76 (35.5%) exhibited cerebral infarctions. More than 74% of the subjects exhibited amyloid angiopathy with a mean score of 1.4±1.2. After controlling for age and sex, apoE &egr;4 increased the odds of cerebral infarction by 2.3-fold (95% CI, 1.2 to 4.2). apoE &egr;4 increased the odds of cortical 3.2-fold (95% CI, 1.3 to 7.7) and subcortical infarctions 2.3-fold (95% CI, 1.2 to 4.5). The effect was unchanged after accounting for amyloid angiopathy. Conclusions— apoE &egr;4 increases the odds of chronic cerebral infarction detected at autopsy in older persons.
ASSESSMENT AND MANAGEMENT OF PSYCHOLOGICAL PROBLEMS IN THE DIZZY PATIENT

Investigations over the last 20 years have moved the field of neuro-otology beyond the nonspecific concept of psychogenic dizziness to a more detailed understanding of interactions between neuro-otological and psychiatric disorders. Diagnostic studies of patients with Ménière's disease, vestibular neuritis, and benign paroxysmal positional vertigo suggest a model in which patients with predisposing factors, such as anxious temperaments or persistent anxiety during acute vestibular crises, are more likely to develop chronic dizziness with comorbid anxiety or depressive disorders. Outcome studies of patients with dizziness have shown that long-term disability depends more on psychological than physical factors. These medical-psychiatric interactions hold the keys to effective management of many patients with dizziness. Laboratory research has revealed neuroanatomical connections between central vestibular pathways and networks in the brain that control fear-related behavioral responses. These likely serve normal physiological functions in all individuals but appear to be the substrate for the close association between dizziness and anxiety in neuro-otological patients. Clinical studies of dizzy patients without active neuro-otological deficits have defined a syndrome of subjective dizziness and persistent imbalance known as phobic postural vertigo or chronic subjective dizziness. This syndrome can be reliably distinguished from other causes of chronic dizziness. Traumatic brain injuries, dysautonomias, and migraine headaches may cause a perplexing pattern of chronic or recurrent dizziness that is easily mistaken for a psychosomatic illness. Antidepressant medications, vestibular and balance rehabilitation therapy, and cognitive psychotherapy are showing increasing promise for treating both physical and psychological symptoms in patients with chronic dizziness due to various illnesses.
Les deux varietes de jaune de plomb et d'etain: etude chronologique

AbstractHaving first differentiated the two types of lead-tin yellow by X-ray microanalysis, it was then possible to establish which type was used in various fourteenth- and fifteenth-century European paintings.In Italy it appears that type I(Pb2SnO4) replaced type II(‘PbSnO3’) during the second quarter of the fifteenth century. However, it has not been possible to confirm the hypothesis of a northern origin for type I, due to a lack of suitable samples. The titles and dates of more than 100 paintings prior to 1500 are listed, together with the type of lead-tin yellow used.
Menor vasoconstricción precoz dependiente del endotelio en la arteria que causa el infarto tras angioplastia primaria en comparación con trombolisis después de un infarto agudo de miocardio

Introduccion y objetivos. En pacientes con un infarto agudo de miocardio con elevacion del ST tratado con trombolisis, se ha documentado una disfuncion endotelial precoz de la arteria que causa el infarto, asi como una mejoria de esta a largo plazo. Nuestro objetivo fue valorar el grado de disfuncion endotelial despues de una angioplastia primaria y en comparacion con la trombolisis. Metodos. La funcion endotelial fue valorada 9 dias despues del infarto infundiendo acetilcolina a concentraciones crecientes y luego nitroglicerina en la arteria origen del infarto de 16 pacientes tratados con angioplastia primaria e implante de stent metalico. La funcion endotelial fue comparada con la de un grupo de 16 pacientes tratados con trombolisis en otro momento. Evaluamos los cambios medios en el diametro de los segmentos distales a la lesion causal o tratada, mediante angiografia coronaria cuantitativa. Resultados. Las caracteristicas basales fueron similares en ambos grupos, a excepcion del tratamiento con clopidogrel en el grupo de angioplastia primaria y la estenosis residual de la arteria origen del infarto (del 3% en el grupo de angioplastia primaria frente al 62% del grupo de trombolisis). Con la concentracion maxima de acetilcolina, el grupo tratado con angioplastia primaria mostro menor vasoconstriccion que el grupo tratado con trombolisis (-4 ± 5% frente a -20 ± 21%; p = 0,018). Conclusiones. Los pacientes con un infarto agudo de miocardio tratados con angioplastia primaria e implante de stent metalico tienen menor vasoconstriccion precoz dependiente del endotelio que los tratados con trombolisis.
A 12-bit 500KSPS cyclic ADC for CMOS image sensor

At present, single-slope analog-to-digital convertor (ADC) is widely used in the readout circuits of CMOS image sensor (CIS) while its main drawback is the high demand for the system clock frequency. The more pixels and higher ADC resolution the image sensor system needs, the higher system clock frequency is required. To overcome this problem in high dynamic range CIS system, this paper presents a 12-bit 500-KS/s cyclic ADC, in which the system clock frequency is 5MHz. Therefore, comparing with the system frequency of 2N×fS for the single-slope ADC, where fS, N is the sampling frequency and resolution, respectively, the higher ADC resolution doesn’t need the higher system clock frequency. With 0. 18μm CMOS process, the circuit layout is realized and occupies an area of 8μm×374μm. Post simulation results show that Signal-to-Noise-and-Distortion-Ratio (SNDR) and Efficient Number of Bit (ENOB) reaches 63.7dB and 10.3bit, respectively.
Electrical Stimulation in Obstructive Sleep Apnoea: the TESLA-home trial

Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections.
Criteria of assessing quick reaction in taekwondo athletes aged 12-25

Background & Study Aim: There are a number of factors that determine the effectiveness of technical and tactical activities in combat sports. The cognitive aim of the research was to acquire the knowledge about basic credibility criteria (reliability and diagnostic validity) of selected tests included in Batak Lite as measuring criteria of quick reaction. The application aim was to adapt norms for controlling quick reaction of female and male taekwondo athletes at various levels of sports advancement. Material & Methods: The research sample was 292 taekwondo athletes (112 females, 180 males); aged 12-25 years. The analysis included 4 selected tests included in Batak Lite. To define the reliability of the tests, the research was carried out twice with an interval of 3-5 days (test-retest). Diagnostic validity was determined with the use of the selected tests included in the Vienna Test System and two main criteria: technical and coordination levels (TC) of competitors and their sports mastery (SM). Norms for female and male athletes were defined in four age categories. Results: Batak Lite selected tests demonstrated reliability coefficients r > 0.50 and, in most cases, validity coefficients r > 0.30. Thus, they met the credibility requirements within the applied criteria. The highest validity coefficients were observed in tests of the Vienna Test System assessing choice reaction in females (r = 0.34 to 0.62) and males (r = 0.31 to 0.38) and simple reaction in male competitors only (r = 0.30 to 0.50). Conclusions: Four Batak Lite tests (I, II, IV and V) displayed sufficient reliability and diagnostic validity, which proved their usefulness when assessing quick reaction of taekwondo athletes.
The Effect of Stabilization Exercise with and without Aquatic Exercise on Pain and Disability of Female Patients with Chronic Low Back Pain

Introduction: Low back pain is one of the most common musculoskeletal disorders. Due to complicated mechanisms of chronic low back pain, determining efficient and cost effective methods of treatment still is a challenge. The aim of this study was to compare the effects of stability exercise with and without aquatic exercise on chronic low back pain. Methods: twenty four Female with chronic low back pain due to disc degeneration or herniation recruited purposefully. They were matched and randomly assigned into stabilization exercise group and combined (stabilization plus aquatic exercise) group. Both groups received 6 weeks exercise intervention (three sessions per week). Pain (VAS) and functional disability (ODI) were assessed before and after interventions. Paired and independent t tests were used for analysis of data (P≤0.05). Results: The results showed significant reduction of VAS scores in stabilization (5.9±0.8 vs 3.8±1.1, P=0.00) and combined (6.2±0.6 vs 3.2±0.9, P=0.00) groups. Regarding disability, significant improvements was seen in stabilization (38.7±9 vs 26.3±9.4, P=0.00) and combined (39.4±8.3 vs 22.5±6.7, P=0.00) groups. Also significant differences was seen between groups, as combined group had around 12.9 % and 10.7% more reduction respectively in VAS (P=0.01) and ODI (P=0.02) scores. Conclusion: As combining aquatic exercises with core stability training could provide higher improvements in pain and functional disability of patients, we suggest aquatic exercise training should be added to rehabilitation programs of low back patients as a complementary modality.
The effect of anti-α4 integrin antibody on brain lesion activity in MS

Objective: To determine the effect of humanized monoclonal antibody against α4 integrin (reactive with α4β1 integrin or very-late antigen–4) on MRI lesion activity in MS. Methods: A randomized, double-blind, placebo-controlled trial in 72 patients with active relapsing-remitting and secondary progressive MS was performed. Each patient received two IV infusions of anti-α4 integrin antibody (natalizumab; Antegren) or placebo 4 weeks apart and was followed up for 24 weeks with serial MRI and clinical assessment. Results: The treated group exhibited significantly fewer new active lesions (mean 1.8 versus 3.6 per patient) and new enhancing lesions (mean 1.6 versus 3.3 per patient) than the placebo group over the first 12 weeks. There was no significant difference in the number of new active or new enhancing lesions in the second 12 weeks of the study. The number of baseline-enhancing lesions (i.e., lesions that enhanced on the baseline scan) that continued to enhance 4 weeks following the first treatment was not significantly different between the two groups. The number of patients with acute MS exacerbations was not significantly different in the two groups during the first 12 weeks (9 in the treated group versus 10 in placebo) but was higher in the treatment group in the second 12 weeks (14 versus 3; p = 0.005). The study was not, however, designed to look definitively at the effect of treatment on relapse rate. Treatment was well tolerated. Conclusions: Short-term treatment with monoclonal antibody against α4 integrin results in a significant reduction in the number of new active lesions on MRI. Further studies will be required to determine the longer term effect of this treatment on MRI and clinical outcomes.
DIABETIC DISTAL SYMMETRIC POLYNEUROPATHY: ROLE OF PHYSICAL EXAMINATION IN SCREENING

Introduction: The aim of this study was to determine the frequency of distal symmetric polyneuropathy (DSP) and the role of physical examination for neuropathy diagnosis in subjects with type 2 diabetes mellitus. Materials and Methods: A cross-sectional study was carried out from 2009 to 2010. A total of 107 patients with type 2 diabetes were evaluated using the Michigan Neuropathy Screening Instrument (MNSI). MNSI consists of two parts: History and physical assessment. History was focused on positive (burning, tingling) and negative (numbness) sensory symptoms, cramps and muscle weakness, foots ulcers or cracks, and prior diagnoses of diabetic neuropathy by a physician. Physical assessment was determined from foot appearance, ulceration, ankle reflexes, vibratory perception and monofilament testing. Results: A total of 72 women and 35 men were participated in this study. The frequency of neuropathy diagnosed based on physical assessment was 78.5%. The mean age was 57.6 (± 10.2) and the mean duration of diabetes was 10.2 (± 7.3) years. Ankle reflexes were not observed in both both foot in 67% of patients. Vibration perception was absent in 25% of patients. Monofilament testing was normal in 86% of patients in both feet. Conclusion: The results showed a key role of physical examination in diagnosis of DSP in diabetic patients. The high frequency of DSP among diabetic patients demonstrated the importance of annual screening, further evaluations, planning and management of patients in diabetic foot clinics. However, considering the results of this study, the sensitivity of monofilament test in screening of DSP is questionable.
Health Literacy in Web-Based Health Information Environments: Systematic Review of Concepts, Definitions, and Operationalization for Measurement

Background Health literacy research seems to lack a consensus on what aspects to include into literacy in the context of health and on how to operationalize these concepts for measurement purposes. In addition to health literacy, several other concepts, such as electronic health (eHealth) literacy and mental health literacy, have been developed across disciplines. This study examines how these different concepts are used when studying health-related competencies in Web contexts. Objective This study systematically reviews health literacy concepts and definitions and their operationalization in studies focused on Web-based health information environments. Methods A systematic literature search was conducted in April 2016 in 6 electronic databases with a limitation to articles in English published between January 2011 and April 2016. Altogether, 1289 unique records were identified and screened according to the predefined inclusion criteria: (1) original, peer-reviewed research articles written in English; (2) the topic of the article concerned literacy in the context of health; (3) informants of the study were lay people, not health professionals or students of the field; and (4) the focus of the study was placed on an Web-based information environment. In total, 180 full texts were screened, of which 68 were included in the review. The studies were analyzed with an emphasis on the used health literacy concepts and measures. Results On the basis of the included studies, several concepts are in use when studying health-related literacy in Web environments, eHealth literacy and health literacy being the most common ones. The reviewed studies represent a variety of disciplines, but mostly medical sciences. Typically, quantitative research methods are used. On the basis of the definitions for health literacy, 3 thematic categories were identified: general and skill-based, multidimensional, and domain-specific health literacy. Most studies adopted a domain-specific concept, followed by the ones that used a general and skill-based concept. Multidimensional concepts occurred least frequently. The general health literacy concepts were usually operationalized with reading comprehension measures, the domain-specific concepts with self-efficacy measures, and multidimensional concepts with several types of measures. However, inconsistencies in operationalization were identified. Conclusions The results show that in studies conducted in Web-based information environments, several different health literacy concepts are in use, and there is no clear consensus on the definitions for these concepts. Future studies should place emphasis on the conceptual development of health literacy in Web contexts to gain better results on operationalization for measurement. Researchers are encouraged to provide clear operational definitions for the concepts they use to ensure transparency in reporting.
On anticipatory iterative learning control designs for continuous time nonlinear dynamic systems

Many schemes of iterative learning control (ILC) have been developed for continuous time nonlinear dynamic systems to improve tracking performance. Two schemes, D-type and P-type, have been the bases for many advanced ILC designs. Recently, a new anticipatory ILC scheme has been introduced. In this paper, these basic schemes are compared from both analysis and implementation view points. The anticipatory ILC scheme is discussed in details. This updating law is designed based on the pair of action taken and its resulting state variables. A sampled data ILC scheme is used as a typical form of this scheme. Experimental results show the effectiveness of this scheme.
Randomized phase II/III trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) Trial - E4599

LBA4 Background: The results of a randomized phase II trial of PC +/- bevacizumab (A) suggested improved activity for the combination of PCA when compared to PC alone (Johnson DH, et al JCO 2004). Grade 5 hemoptysis was seen in the PCA arms & multivariate analysis suggested squamous cell histology to be a significant risk factor. Methods: The primary endpoint of this randomized trial was to compare the effects of the addition of A to PC on overall survival in patients (pts) with previously untreated non-squamous NSCLC. Secondary endpoints included response rate, time to progression, and tolerability. Correlative studies consisted of pre & post-treatment circulating VEGF, VCAM, E-selectin & bFGF as prognostic & predictive markers. Other eligibility criteria included ECOG PS 0 or 1, & adequate hematologic, renal, & hepatic function. Pts with brain metastases were excluded. Pts were randomized to receive P 200 mg/m2 + C AUC=6 on day 1 every 3 wks or PC + A 15mg/kg day 1 (PCA) every 3 weeks. Pts on PCA contin.
The Association Between Blood Lead Level and Microcytic Hypochoromic Anemia in Children

Background: Iron deficiency, as the most common nutritional deficiency, often occurs in the pediatric age group due to rapid growth and low dietary iron content. Objectives: The present study aimed to assess the relationship between microcytic hypochromic anemia and blood lead level below the standard acceptable upper range in children aged between one and ten years. Methods: In this study, 27 cases, who fulfilled the inclusion criteria were assigned to group A, as hypochromic microcytic anemia with iron deficiency. Another 18 hypochromic microcytic anemia cases with normal ferritin levels were assigned to group B. Besides, 20 healthy children were chosen as the control group. All the statistical analyses were performed using the SPSS statistical software. P values of < 0.05 were considered to be statistically significant. Results: The children in group A showed significant correlations between lead levels and hemoglobin (-0.770; P values = 0.001), mean corpuscular volume (MCV) (-0.679; P values = 0.001), and ferritin (-0.509; P values < 0.001). In group B, only a significant correlation was observed between lead levels and ferritin (-0.637; P values = 0.001). In the control group, a significant correlation was found between lead levels and MCV (-0.483; P values = 0.031) and ferritin (-0.562; P values = 0.010). Multiple comparisons test showed significant mean differences (± SD) between the control group and groups A (1.26 ± 0.28; P values = 0.001) and B (1.78 ± 0.31; Pvalues = 0.001) regarding the lead levels, but no significant difference was seen between groups A and B in this regard. Conclusions: Our study results imply that there is no secure threshold for blood lead level at which, lead begins to cause interruption with hematologic parameters in young children.