Miracle-dz/UniFAR-FTUs huggingface dataset:
Evalution of Autoimmunity in Patients with Primary Cutaneous Vasculitis

1 Hatice Uce Özkol1, Ayşe Serap Karadağ2, Ömer Calka1, Necmettin Akdeniz2, Gülay Bulut3, İlknur Yorgun Özdemir1 1Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Dermatoloji AD, Van, 2Medeniyet Üniversitesi, Tıp Fakültesi, Göztepe Eğitim ve Araştırma Hastanesi, Dermatoloji Kliniği, İstanbul, 3Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Patoloji AD, Van, Türkiye Primer Kutanöz Vaskülit / Primary Cutaneous Vasculitis Evalution of Autoimmunity in Patients with Primary Cutaneous Vasculitis
The Effect of Varying Water Soluble Components on the Radiative Forcing of Continental Average Aerosols

This work embodies the results of the effect of the water soluble components on the radiative forcing of continental average aerosols, from aerosol data extracted from optical properties of aerosols and cloud (OPAC) 4.0 software package using FORTRAN program to model the effect of water soluble on optical depth, asymmetric parameter, scattering and absorption coefficients at the spectral range of (0.25-0.80µm) and at eight relative humidities (0%,50%,70%,80%,90%,95%,98% & 99%). The concentration of water soluble was varied while concentrations of water insoluble and soot were kept constant. The optical parameters were used to compute numerically the radiative forcing using the concept of chylek and wong, the Angstrom exponent (α), turbidity (β) and Curvature . Keywords: Angstrom exponent, Curvature, Optical depth, Radiative forcing, Turbidity. DOI: 10.7176/APTA/79-04 Publication date:September 30th 2019
Recent advances in pore water pressure and liquefaction characteristics of low plasticity silty sands subjected to cyclic loading

Low plasticity sand-silt mixtures are very common in Italy either in natural depositional environment or in man-made earth-fill, hence the knowledge of their behavior is a crucial aspect in many practical applications. Due to higher compressibility features, significant strains and strength loss may be triggered by earthquakes. The results of a laboratory-based investigation undertaken on undisturbed samples of low plasticity silty-sandy soils recovered from a bank stretch after the 2012 Emilia Romagna earthquake in Italy, when serious damages and widespread liquefaction events were observed, are herein presented. Special emphasis was given to susceptibility to liquefaction and pore water pressure response in presence of an initial static shear stress. As part of the present work, the results of undrained cyclic simple shear (CSS) tests carried out on reconstituted specimens of sand-fines mixtures, covering a range of non plastic fines contents from 0% to 40%, were used for predicting undrained cyclic resistance through the concept of equivalent granular void ratio, e*. The conceptual framework based on e* appears appropriate for streamlining the effect of fines on cyclic liquefaction resistance of these intermediate soils, provided that fines content is less than a limiting value. Since an important stage in the assessment of liquefaction potential is to predict excess pore water pressure during cyclic loading, the results of CSS tests were also utilized for analysing pore water pressure generation models of silty sands over a wide range of fines contents.
High-NA EUV Lithography exposure tool: program progress and mask impact (Conference Presentation)

While EUV systems equipped with a 0.33 Numerical Aperture (NA) lens are readying to start high volume manufacturing, ASML and ZEISS are in parallel ramping up their activities on an EUV exposure tool with an NA of 0.55. The purpose of this high-NA scanner, targeting a resolution of 8nm, is to extend Moore’s law throughout the next decade. A novel lens design, capable of providing the required Numerical Aperture, has been identified; this lens will be paired with new, faster stages and more accurate sensors enabling the tight focus and overlay control needed for future process nodes. In this paper an update will be given on the status of the developments at ZEISS and ASML. Next to this, we will address several topics concerning the interaction of the High-NA optics and its associated different magnifications on requirements for the mask, in particular defectivity, flatness, substrate thermal properties, novel absorbers, need for assist features, pellicle and stitching.
COMFORT AND PLANTAR PRESSURE PATTERN DURING RUNNING WITH PREFABRICATED INSOLES

The aim of this study was to investigate the relationship between plantar pressure pattern and wearing comfort of five different prefabricated insoles. Therefore wearing comfort was assessed by a questionnaire and the use of a visual analogue scale (VAS) and plantar pressure was measured by a Pedar-­X system. For statistical analysis single factor ANOVA for repeated measurements, Bonferroni and Pearson correlation test were performed. Significant differences in comfort ratings and average maximum plantar pressure were found. A relationship between average plantar pressure and comfort could not be detected. Nevertheless prefabricated insoles are able to improve wearing comfort of running shoes. Additional parameters like insole hardness and/or flexibility might also influence wearing comfort and seems to modulate the plantar pressure pattern during running.
La drépanocytose : de l'enfant à l'adolescent. Prise en charge en 2001.

La maladie drepanocytaire (drepanocytose homozygote SS, double heterozygote SC et β-thalasso-drepanocytose) evolue sur un mode chronique: etat basal, entrecoupe de complications aigues, etat critique, pour lesquels la prise en charge doit etre globale. Savoir traiter les crises suppose un centre equipe et habitue a des diagnostics cliniques souvent complexes: infarctus osseux ou osteomyelite, pneumopathie ou syndrome thoracique aigu, crise multifocale ou syndrome infectieux severe. Le depistage neonatal permet une prise en charge precoce et l'instauration de mesures preventives efficaces: traitement antipneumococcique et hydratation, education des familles, surveillance specialisee. Des progres ont ete faits pour le depistage precoce de la retinite, de la lithiase biliaire, de la necrose de la hanche et pour les indications de traitement par l'hydroxyuree. La creation de centres de drepanocytose est a encourager pour mieux traiter ces malades encore trop disperses et atteints d'une affection encore peu connue.
Role of Pharmacokinetic Studies in Drug Discovery

Over the last few years, Pharmacokinetics has emerged as an integral part of drug development, especially when identifying a drug’s biological properties. Understanding of pharmacokinetic and metabolism characteristic of the drug compounds is needed in designing appropriate human clinical trials. This document describes the basic principles of pharmacokinetic studies necessary for the submission of a new drug application and for re-examination of approved drugs.
Diagnostyka i leczenie zwężenia tętnic nerkowych — przegląd metod

Zwezenie tetnic nerkowych (RAS) wystepuje u 6–8% osob po 65. roku zycia. Skutkami zwezenia są zwiekszenie czestości wystepowania incydentow sercowo-naczyniowych oraz wyzsza śmiertelnośc pacjentow. Ciągly rozwoj metod diagnostycznych ulatwia wykrycie tej patologii oraz umozliwia jej dokladny opis. Sposob leczenia RAS oraz jego skutkow wciąz nie zostal jednoznacznie ustalony. Opublikowane dotychczas wyniki badan dowiodly wyzszośc leczenia farmakologicznego nad postepowaniem zabiegowym, jednak wskazano na licznenie dopatrzenia w sposobie ich przeprowadzenia.Skutkowalo to rozpoczeciem kolejnych badan, ktorych wyniki jeszcze nie są znane. Celem tej pracy jest przedstawienie aktualnych sposobow diagnostyki i leczenia RAS oraz opis przeprowadzonych dotychczas badan, w ktorych porownywano rozne strategie leczenia.
Preliminary geologic investigation of the Apollo 15 landing site

The Apollo 15 lunar module (LM) landed on the mare surface of Palus Putredinis on the eastern edge of the Imbrium Basin. The site is between the Apennine Mountain front and Hadley Rille. The objectives of the mission, in order of decreasing priority, were description and sampling of three major geologic features-the Apennine Front, Hadley Rille, and the mare. The greater number of periods of extravehicular activity (EVA) and the mobility provided by the lunar roving vehicle (ROVER) allowed much more geologic information to be obtained from a much larger area than those explored by previous Apollo crews. A total of 5 hours was spent at traverse station stops, and the astronauts transmitted excellent descriptions of the lunar surface while in transit between stations.
A double-blind comparative study of sodium valproate in treating of TD

Objective:To explore the effect and security of sodium valproate in the treatment of TD caused by antipsychotics. Method:80 male inpatients who met with the criteria of schizophrenia and TD were divided randomly into sodium valproate group and the control group with placebo. The efficacy and safety were assessed with AIMS,BPRS and TESS at the end of week 1,2,4 and 6. Results:The validity rates of sodium valproate group and the control group were 64.1% and 25.0% respectively. The scores of AIMS were significantly lower in sodium valproate group than that in controls at the end of week 6( P 0.01). Conclusion: Lower dose sodium valproate is effective in the treatment of TD caused by antipsychotics. Close attention should be paid to the platelet count.
Anti-inflammatory Activities of GyejigaChulBuTang on Lipopolysaccharide-stimulated RAW264.7 Cells

Objectives GyejigaChulBuTang (GCBT) is a prescription used to treat acute and chronic arthritis in Korea, China, and Japan. This study assessed the anti-inflammatory and anti-oxidant activities of GCBT on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Methods Raw264.7 cells were pretreated with or without GCBT for 1 hour prior to incubation with LPS. Anti-inflammatory activity of GCBT was evaluated with reference to gene expression and production levels of proinflammatory cytokines (, IL-, IL-6, GM-CSF and ) and inflammatory mediators (iNOS, COX-2, NO and ). In addition, intracellular ROS generation and signal transduction of MAPK family, PI3K/Akt and was investigated. Results Prior treatment with GCBT inhibited elevation of , IL-, IL-6, GM-CSF, , NO and , together with their cognate mRNAs in a dose-dependent manner. Intracellular ROS contents were similarly reduced. These effects were due to inhibition of LPS-induced phosphorylation of MAPK family, PI3K/Akt and as well as nuclear translocation of . Conclusions GCBT suppresses pro-inflammatory mediators. GCBT has potential in the treatment of juvenile rheumatoid arthritis associated with inflammation.
Hypoglycemic, Hematologic and Hypolipidemic Activity of Mucuna Pruriens Ethanol Leaf Extract in Alloxan Induced Diabetic Rats

Aim: This study investigated the hypoglycemic, hematologic and hypolipidemic potentials of Mucuna pruriens ethanol leaf extract (MELE) in alloxan induced diabetic rats. Study Design: Experimental Animal Model. The study was conducted in the Physiology Laboratory of the Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture, Umudike, Nigeria between November, 2013 and February, 2014. Methodology: Diabetic rats were divided into 4 groups of 7 animals each (groups 2-5). Group1 comprising of 7 normal rats received 0.2ml normal saline and served as the normal control group. Group 2 received no treatment and served as the diabetic control group. Group 3 was treated with a reference drug, Glibenclamide (5mg/kg) while groups 4 and 5 received 150 and 300mg/kg of MELE respectively. All treatments were done via the oral route and lasted for 21 days. Results: Alldoses of MELE significantly (P<.05) lowered glucose levels in the diabetic rats with 300mg/kg lowering blood glucose from 311.80 ± 37.10 in diabetic rats to 91.30 ± 2.26 by the end of 21 days. The hypoglycemic effect of MELE compared favorably with that of Glibenclamide. Red blood cells (RBC) counts, packed cell volume (PCV),hemoglobin Original Research Article Annual Research & Review in Biology, 4(24): 4284-4292, 2014 4285 values were all significantly raised (P<.05) in treated rats, while the increased WBC value in diabetic rats was lowered. The levels of total cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) were significantly (P<.05) decreased in the diabetic treated rats with increase in the levels of high density lipoprotein cholesterol (HDL-C). Conclusion: These results suggest that MELE contain active principles with hypoglycemic, hematologic and hypolipidemic properties and could be valuable in managing diabetic mellitus and correcting the hematological and lipid profile abnormalities associated with the pathophysiology of the disease.
The Role of Emotion in Group Cognitive-Behavioral Therapy for Binge Eating Disorder: When Things Have to Feel Worse Before They Get Better

The goal of this study was to investigate the client's emotional experience in group cognitive-behavioral therapy for binge eating disorder (BED). Sixty-five individuals meeting the DSM-IV criteria for BED completed a 12-week manualized treatment conducted by experienced therapists. As predicted, the client's emotional experience was characterized by both positive and negative emotions. Also as expected, the experience of negative emotions was most prevalent in the middle phase of therapy. The client's emotional experience also discriminated between treatment responders and nonresponders. As predicted, the results suggest that the prevalence of positive feelings (e.g., hope, relief) and perception of positive group climates (e.g., stimulating, affectionate) was related to client change. The findings also suggest that the lack of negative feelings (e.g., worried, upset) in the beginning of treatment and, paradoxically, the perception of negative group climates (e.g., depressed, discouraged, inhibited, tens.
THE INFLUENCE OF ASSESSMENT ON TEACHERS’ TEACHING STYLE IN LIFE SCIENCES: A CASE OF TWO SCHOOLS IN ONE PROVINCE OF SOUTH AFRICA

This study explores the influence of assessment on teachers’ teaching style and learner performance in Life Sciences in two schools of different contexts in one district of the North West province. This paper borrows its constructs from theorists such as Lev Vygotsky’s social constructivism as well as Lave and Wenger’s community of practice. This study followed an exploratory case study approach. Data was collected qualitatively through the interviews and document analysis. The two teachers were purposively selected based on a number of factors, such as location of the school, learner performance in previous years and resource availability, particularly infrastructure. Data gathered were thematically analysed using inductive analysis. Document analysis was used to analyse data from lesson plans and learners exercise books. The findings of the study indicate that assessment enables teachers to identify their shortfalls and mend the gap, thus, allowing them to improve their teaching styles. As learners are continuously assessed by using different forms of assessment, their confidence gets fully build and their performance improve. The paper concludes with recommendations on how effective assessment behaviours can be incorporated by teachers during the teaching and learning process to improve learner attainment.
Immunotherapy and Hepatocellular Carcinoma

Hepatocellular Carcinoma (HCC), the most common primary liver tumor, is the third leading cause of cancer death worldwide and the ninth leading cause of cancer death in the United States [1]. The incidence of HCC in the United States has increased from 2.7 to 3.2 per 100,000 persons over the period 2001-2006, according to the most recent data from the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) surveillance system [2]. Moreover, HCC related to Hepatitis C Virus (HCV) infection is among the fastest-rising causes of cancer death in the US owing to the peak incidence of HCV infection in the aging cohort born between 1945 and 1965 [3].
Long-Term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking

Background and Methods Although patients with chronic obstructive pulmonary disease (COPD) should stop smoking, some do not. In a double-blind, placebo-controlled study, we evaluated the effect of the inhaled glucocorticoid budesonide in subjects with mild COPD who continued smoking. After a six-month run-in period, we randomly assigned 1277 subjects (mean age, 52 years; mean forced expiratory volume in one second [FEV1], 77 percent of the predicted value; 73 percent men) to twice-daily treatment with 400 μg of budesonide or placebo, inhaled from a dry-powder inhaler, for three years. Results Of the 1277 subjects, 912 (71 percent) completed the study. Among these subjects, the median decline in the FEV1 after the use of a bronchodilator over the three-year period was 140 ml in the budesonide group and 180 ml in the placebo group (P=0.05), or 4.3 percent and 5.3 percent of the predicted value, respectively. During the first six months of the study, the FEV1 improved at the rate of 17 ml per year in the bud.
Safety in Managing Patient Test Data: Assessing Perceptions, Attitudes, and Actions

As a gateway to specialty care, primary care relies on patient testing—including laboratory work and imaging—for many kinds of patient diagnoses and treatments. Because of this, patient safety can be adversely affected when testing orders are not tracked, results are lost, or patients are not notified of results. Non-standardized testing management also worsens clinical outcomes, lessens system resilience, and increases clinician workload, costs, and delays. During development of a system to better support patient test tracking, a survey was performed to assess perceptions, attitudes, and actions of current healthcare practitioners. Responses from 261 people show a variety of experience with the phrase “no news is good news” for testing results, attitudes and reactions about health technology, perceptions of usefulness and time consumption of safetyrelated actions, and failures and successes observed throughout testing management processes.
AB0272 Bsmi and Foki VDR Gene Polymorphisms Influence Disease Activity in Established Rheumatoid Arthritis Patients

Background Vitamin D has been shown to have significant immunomodulatory effects. Its actions are mediated by the ubiquitous vitamin D receptor (VDR). In one study, BsmI VDR gene polymorphism was associated with an early onset of rheumatoid arthritis (RA). Additionally, TT genotype of the FokI VDR gene polymorphism was established as a genetic susceptibility marker for RA in French and Tunisian populations. Objectives To determine the degree of association of BsmI and FokI VDR gene polymorphisms with disease activity in patients with established RA. Methods Clinical features and peripheral blood samples were collected from a monitoring visit. The Portuguese version of HAQ and the disease activity scores (DAS28 (4v; ESR), DAS28 (3v; ESR), DAS 28 (4v; CRP), DAS28 (3v; CRP)) were obtained. We measured the following acute phase reactants: ESR and CRP. Genomic DNA was extracted from blood and genotyped for the BsmI (A/G) (rs1544410) and FokI (T/C) (rs 2228570) SNPs by PCR-RFLPs analysis. A multivariate analysis model was used for statistical analysis (IBM SPSS Statistics 21). Results We evaluated 208 RA patients, 166 (80%) women, 65 (31%) premenopausal women, age 54±12 years, disease duration 14±10 years, mean DAS28 (4v) of 4.25±1.33 and a mean HAQ of 1.254±0.709. In our sample, 107 (51%) were under biologics, 87 (42%) under anti-TNFalpha agents and 42 (20%) under vitamin D supplements. Genotype frequencies were determined for the two distinct VDR polymorphisms: BsmI (GG 37%, 44% AG, AA 19%) and FoKI (CC 42%, TC 46%, TT 12%). GG genotype of the BsmI VDR gene polymorphism was associated with higher DAS28 (4v; ESR), DAS28 (3v; ESR), DAS 28 (4v; CRP) and DAS28 (3v; CRP) scores (p<0.001). Additionally, TT genotype of the FokI VDR gene polymorphism was associated with higher DAS28 (4v; ESR), DAS28 (3v; ESR), DAS 28 (4v; CRP) and DAS28 (3v; CRP) scores (p<0.001). In the subgroup of patients without vitamin D supplements, the previously observed associations remained significant (p<0.001). All these associations were found after adjusting for age, disease duration, current HAQ, time under DMARDs therapy, current average daily dose of prednisone and years of corticosteroid use. Conclusions In our RA population, the BsmI GG and the FokI TT genotypes of the VDR gene were related with disease severity. In the future, VDR gene polymorphisms could be useful in establishing RA prognosis. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.3913
Empirical Essays on Health and Aging

This thesis is composed of four chapters: One introductory chapter and three chapters that each include one of the three essays that make up the main body of the thesis. Common features of the essays are empirical assessments of health in later life and the econometrical challenges caused by selection–either in the form of people self-selecting into “treatment” or in the form of sample-selection in the data applied. The first essay, co-authored with Signe A. Abrahamsen, is concerned with how increased access to publicly provided eldercare affects the immediate and long-term health of informal caregivers. The evidence of the causal effects of care responsibilities on health is limited, especially for long-term outcomes. In this essay, we estimate long-term effects of a formal care expansion for the elderly on the health of their middle-aged daughters. We exploit a reform in the federal funding of formal care for Norwegian municipalities that caused a greater expansion of home care provision in municipalities that initially had lower coverage rates. We find that expanding formal care for the elderly reduced sickness absence for single-child daughters of lone parents in the short run, and that the decrease seems to be driven by absences due to musculoskeletal disorders and psychological disorders. When assessing long-term health outcomes for the same group of daughters, we find that, overall, long-term health is not affected. The second essay, co-authored with Otto S. Lillebø, is concerned with the health effects of retirement and the potential heterogeneity in these effects according to socioeconomic status. Using a local randomized experiment that arises from the statutory retirement age in Norway, we estimate causal effects of retirement on health across socioeconomic status. We apply health information from full population administrative registers and from survey data to investigate the effects of retirement on acute hospital admissions, mortality, and a composite physical health score. Our results show that retirement has a positive effect on physical health, especially for individuals with low socioeconomic status. We find no retirement effects on acute hospitalizations or mortality in general. However, our results suggest that retirement leads to reduced likelihood of hospitalizations for individuals with low socioeconomic status. Finally, we show that the positive health effects are driven by reduced pain and reduced health limitations in conducting daily activities. Our findings highlight heterogeneity in the health effects across socioeconomic status and across subjective and objective measures of health. The third essay analyzes the extent and consequences of health-related non-response in survey data, defined as either initial non-response or attrition across waves. The first