Miracle-dz/UniFAR-FTUs huggingface dataset:
Del teatro clásico a los videojuegos educativos

En los ultimos anos, el exito de los videojuegos ha hecho que algunos investigadores hayan abogado por su uso en los entornos educativos. De hecho, no son pocos los estudios que han demostrado que los videojuegos educativos pueden mejorar el rendimiento academico, ofrecer entornos mas propensos para la adquisicion de conocimiento, o incluso, aumentar la motivacion de los alumnos por las materias que se les ensenan. Sin embargo, la mayor parte de estos estudios se han centrado en las disciplinas que se conocen por las siglas en ingles STEM (Ciencia, Tecnologia, Ingenieria y Matematicas). Comparativamente, los estudios orientados al uso de videojuegos educativos en el area de las humanidades son muchos menos. Y si hablamos de disciplinas artisticas, su uso ha sido practicamente nulo. Por otro lado, hemos podido constatar (tanto por diversos informes, como personalmente en los escenarios) que tanto en Espana como en la mayoria de los paises occidentales, los jovenes tienen cada vez menos interes por el teatro, especialmente por el clasico. Diferentes organismos coinciden en que las politicas orientadas a volver a conseguir el interes de los jovenes deben incluir dos sectores: el educativo, y el audiovisual. El objetivo principal de esta tesis ha sido la exploracion de los videojuegos educativos como herramientas motivadoras hacia el teatro clasico (especialmente en los mas jovenes). Para ello, la principal aportacion que se ha formulado ha sido el desarrollo de una metodologia que facilita la creacion de videojuegos educativos a partir de obras de teatro clasicas. Esta metodologia se ha basado en las tecnicas de actuacion propuestas por el actor y dramaturgo ruso Konstantin Stanislavski. Tambien se ha creado, a modo de prueba de concepto, un videojuego basado en La Dama Boba de Lope de Vega utilizando la herramienta eAdventure. Este videojuego se ha probado en un caso de estudio con 754 estudiantes de ocho colegios e institutos de la Comunidad de Madrid. Este experimento ha demostrado la eficiencia de los videojuegos educativos en el ambito del teatro, y ha servido como punto de partida para la ultima contribucion de esta tesis. Un estudio de como el genero, la edad y, especialmente, los habitos y preferencias de juego de los estudiantes afectan a la eficiencia de estos videojuegos educativos
Rethink the Design of Flash Translation Layers in a Component-Based View

NAND flash memory is a popular memory device that has many advantages such as high-density, lightweight, shock-resistance, non-volatile, and low-power features. Although NAND flash memory has many attractive features, it still has several limitations due to its architectural characteristics, such as out-of-place update, erase-before-write feature, and limit of erase count. Therefore, various flash translation layers (FTLs) have been proposed to handle the characteristics. An FTL consists of three main functions, such as address translation, garbage collection, and wear-leveling effect. In order to facilitate developers to realize and design the main functions of FTLs, we propose a component-based view to rethink the design of FTLs. With the component-based view, developers can replace inappropriate components to form a new FTL and dynamically replace the present FTL. Therefore, we also propose the transformation of FTLs to adaptively transform a present FTL to a suitable one. In the experiments, we can demonstrate that the revised FTL (by replacing some components) can improve its original performance and the transformed FTL can also improve the performance under the current workload.
Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.

P URPOSE . In the pathogenesis of diabetic retinopathy, matrix metalloproteinase (MMP)-9 damages retinal mitochondria, activating the apoptotic machinery. Transcription of MMP-9 is regulated by nuclear factor kappa B (NF- j B), and the activation of NF- j B is modulated by the acetylation of its p65 subunit. Sirtuin 1 (Sirt1), a deacetylase, plays an important role in the acetylation-deacetylation of p65. The goal of this study is to investigate the role of Sirt1 in the activation of MMP-9 in diabetic retinopathy. ETHODS . The effect of hyperglycemia and Sirt1 activator, resveratrol, on acetylation of p65 and its binding at MMP- 9 promoter—and mitochondrial damage and apoptosis—was assessed in the retinal endothelial cells. Role of oxidative stress in the regulation of Sirt1 was evaluated in the cells incubated in H 2 O 2 . The results were conﬁrmed in the retina from diabetic mice with Sod2 or MMP-9 gene manipulated. acetylation, binding of p65 at MMP-9 promoter and MMP-9 activation, mitochondria damage, and cell apoptosis. While Sirt1 was decreased by H 2 O 2 , MMP-9 was signiﬁcantly increased. Retina from wild-type diabetic mice presented similar decrease in Sirt1, and diabetic mice with Sod2 overexpression or MMP-9 deletion had normal retinal Sirt1. Retinal microvasculature from human donors with established diabetic retinopathy also had decreased Sirt1. C ONCLUSIONS . Thus, in diabetes, increase in oxidative stress inhibits Sirt1 and p65 is hyperacetylated, increasing the binding of p65 at MMP-9 promoter. Prevention of Sirt1 inhibition, via modulating acetylation of p65, should protect activation of MMP-9 and inhibit the development of diabetic retinopathy. the acetylation of p65, its binding at MMP-9 promoter and mitochondria damage. The results were conﬁrmed in retina from mice with MMP-9 gene manipulated, and the key ﬁndings were investigated in the retinal microvasculature from human donors with diabetic retinopathy.
Compassion Fatigue and Burnout: What Managers Should Know

Most health care employees experience and are bolstered by compassion satisfaction as they deal with patients in need. However, the more empathetic a health care provider is, the more likely he or she will experience compassion fatigue. Compassion fatigue is a negative syndrome that occurs when dealing with the traumatic experiences of patients, and examples of symptoms include intrusive thoughts, sleeping problems, and depression. Compassion fatigue is different from burnout. Compassion fatigue is a rapidly occurring disorder for primary health care workers who work with suffering patients, whereas burnout, a larger construct, is a slowly progressing disorder for employees who typically are working in burdensome organizational environments. Managers can mitigate problems associated with compassion fatigue with a number of interventions including patient reassignments, formal mentoring programs, employee training, and a compassionate organizational culture. With burnout, health care managers will want to focus primarily on chronic organizational problems.
Dimension reduction of microarray data based on local tangent space alignment

We introduce the new nonlinear dimension reduction method: LTSA, in dealing with the difficulty of analyzing high-dimensional, nonlinear microarray data. Firstly, we analyze the applicability of the method and we propose the reconstruction error of LTSA. The method is tested on Iris data set and acute leukemias microarray data. The results show good visualization performance. And LTSA outperforms PCA on determining the reduced dimension. There is only subtle change in the clustering correctness after dimension reduction by LTSA. It is evident that application of nonlinear dimension reduction techniques could have a promising perspective in microarray data analysis.
Pulmonary function and high‐resolution CT findings five years after disease onset in patients with Wegener's granulomatosis

Objective: Although pulmonary involvement is common in Wegener's granulomatosis (WG), little is known about the pulmonary outcome. We evaluated the relationship between clinical disease characteristics and pulmonary function and high‐resolution computed tomography (HRCT) findings after disease duration of 5 years. Methods: A pulmonary function test (PFT) and pulmonary HRCT were performed in 41 patients from a population‐based register of WG. Clinical predictors for abnormal PFT and HRCT were tested by logistic regression. Results: Previous WG‐related lung involvement (PLI) had occurred in 80% of patients, but only 24% of patients still reported pulmonary symptoms at the research visit. One‐third of patients had abnormal PFT findings, with reduced alveolar diffusion by KCO (transfer coefficient) being most common (24%). The number of PLI episodes was associated with reduced KCO and reduced FEV1% (forced expiratory volume in 1 s as a percentage of forced vital capacity) (overall presence 10%). Reduced KCO was also associated with disease duration. Reduced total lung capacity (TLC) (overall presence 8%) was only related to prior WG‐related lung nodules. Pulmonary HRCT was abnormal in 80%, but with more severe abnormalities in only 30%. Pleural thickening and parenchymal bands were associated with PLI. None of the treatment variables was associated with the PFT or HRCT findings. Conclusion: Five years after disease onset a quarter of the WG patients reported pulmonary symptoms, had severe abnormalities on HRCT, and abnormal PFT. The correlation between these abnormalities was poor, but the number of pulmonary involvements was a risk factor for reduced gas diffusion, obstructive lung disease, parenchymal bands, and pleural thickening. Treatment variables had no discernible negative pulmonary effects.
Systemic therapy of inflammatory breast cancer from high‐dose chemotherapy to targeted therapies

Aggressiveness of inflammatory breast cancer (IBC) is related to its metastatic potential. The introduction of primary chemotherapy in the multimodality treatment has dramatically changed the prognosis. However, survival remains poor. Since 1995, innovative systemic therapies have been assessed in France in multicentric clinical trials, initially centered on high‐dose chemotherapy (HDC) with hematopoietic stem cell transplantation (HSCT), and, more recently, on targeted therapies.
Poster: Amplitude test for input devices for system control in immersive virtual environment

In this study, the amplitudes best suited to compare four input devices are examined in the context of a pointer-based system control interface for immersive virtual environments. The interfaces are based on a pen and tablet, a touch tablet, hand-tracking using Kinect and a Wii Nunchuk analog stick. This is done as a preliminary study in order to be able to compare the interfaces with the goal of evaluating them in the context of using virtual environments in a class lecture. Five amplitudes are tested for each of the four interfaces by having test participants mark menu elements in an eight-part radial menu using each combination of amplitude and interface. The amplitudes to be used for future experiments were found. Also, the movement times for the interfaces do not fit the predictions of Fitts' law.
Design, fabrication and measurement of a dual-band circularly-polarized stacked microstrip antenna for Galileo and GPS

This paper deals with the design, fabrication and measurement of a dual-band circularly-polarized stacked microstrip antenna for Galileo (E5a, E5b, E2 and E1 bands) and GPS (L2 band). A feeding network composed of three Wilkinson power combiners is used to generate the required circular polarization.
Coagulation concepts update.

OBJECTIVE Since the previous comprehensive radiology review on coagulation concepts that was done in 1990, many studies have been published in the medical and surgical literature that can guide the approach of a radiology practice. The purpose of this article is to provide an analysis of these works, updating the radiologist on proper use and interpretation of coagulation assessment tools, medications that modify the hemostatic system, and the use of transfusions prior to interventions. CONCLUSION The basic tools for coagulation assessment have not changed; however, results from subspecialty research have suggested ways in which the use of these tools can be modified and streamlined to safely reduce time and expense for the patient and the health care system.
A desumanização do comer

Considerando o "ato de comer" como ato humano e humanizador por excelencia, este artigo procura tracar a trajetoria historica do fenomeno da refeicao na tradicao ocidental, partindo de referenciais culturais judaico-cristaos - a Biblia - e helenicos - O banquete de Platao -, e analisar o processo de sua desumanizacao no contexto da sociedade industrial pos-moderna, assim como seus efeitos na cultura.
Elevated Carbon Dioxide Improves Plant Iron Nutrition through Enhancing the Iron-Deficiency-Induced Responses under Iron-Limited Conditions in Tomato1[OA]

The increases in atmospheric carbon dioxide (CO2) concentrations can enhance plant growth and change their nutrient demands. We report that when tomato (Lycopersicon esculentum ‘Zheza 809’) plants were grown in iron (Fe)-limited medium (with hydrous ferric iron oxide) and elevated CO2 (800 μL L−1), their biomass and root-to-shoot ratio were greater than plants grown in ambient CO2 (350 μL L−1). Furthermore, the associated increase in Fe concentrations in the shoots and roots alleviated Fe-deficiency-induced chlorosis. Despite the improved nutrient status of plants grown in Fe-limited medium under elevated CO2, the Fe-deficiency-induced responses in roots, including ferric chelate reductase activity, proton secretion, subapical root hair development, and the expression of FER, FRO1, and IRT genes, were all greater than plants grown in the ambient CO2. The biomass of plants grown in Fe-sufficient medium was also increased by the elevated CO2 treatment, but changes in tissue Fe concentrations and Fe deficiency responses were not observed. These results suggest that the improved Fe nutrition and induction of Fe-deficient-induced responses in plants grown in Fe-limited medium under elevated CO2 are caused by interactions between elevated CO2 and Fe deprivation. Elevated CO2 also increased the nitric oxide (NO) levels in roots, but treatment with the NO scavenger cPTIO inhibited ferric chelate reductase activity and prevented the accumulation of LeFRO1, LeIRT1, and FER transcripts in roots of the Fe-limited plants. These results implicate some involvement of NO in enhancing Fe-deficiency-induced responses when Fe limitation and elevated CO2 occur together. We propose that the combination of elevated CO2 and Fe limitation induces morphological, physiological, and molecular responses that enhance the capacity for plants to access and utilize Fe from sparingly soluble sources, such as Fe(III)-oxide.
Evaluation of science as consultancy

Le discours actuel sur les evaluations institutionnelles de la recherche s’est construit autour d’une these dominante : en tant que controle de la performance initie par l’exterieur, les evaluations sont considerees comme l’expression, et le moteur, d’une deprofessionnalisation globale de la profession academique. Les evaluateurs comme les chercheurs evalues supposent qu’ils devront ajuster leurs systemes de valeurs et d’evaluation a des criteres externes. Notre analyse empirique des procedures d’evaluation a un niveau microsociologique se distance de cette these, et montre que les valeurs centrales de la profession academique persistent, et continuent a structurer la prise de decision et les actions de celle-ci. Une de ces valeurs stipule que les evaluations ne sont pas seulement au service du controle de la performance et de la sanction, mais qu’elles apportent les conseils de collegues. Mais comment le conseil est-il possible dans un contexte de controle de la performance, dont les consequences sont potentiellement graves ? Nous repondons a cette question en analysant les decisions et les actions d’evaluateurs, et de chercheurs evalues, dans le cadre de la procedure d’evaluation des instituts de recherche allemands de l’Association Leibniz.
Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene.

BACKGROUND Myofibrillar myopathies, often referred to as desmin-related myopathies, are a heterogeneous group of inherited or sporadic distal-onset skeletal myopathies associated with cardiomyopathy. Among the myofibrillar proteins that characteristically accumulate within the muscle fibers of affected patients, the one found most consistently is desmin, a muscle-specific intermediate-filament protein responsible for the structural integrity of the myofibrils. Skeletal and cardiac myopathy develops in mice that lack desmin, suggesting that mutations in the desmin gene may be pathogenic. METHODS We examined 22 patients from 8 families with dominantly inherited myofibrillar or desmin-related myopathy and 2 patients with sporadic disease and analyzed the desmin gene for mutations, using complementary DNA (cDNA) amplified from muscle-biopsy specimens and genomic DNA extracted from blood lymphocytes. Restriction-enzyme analysis was used to confirm the mutations. Expression vectors containing normal or mutant desmin cDNA were introduced into cultured cells to determine whether the mutant desmin formed intermediate filaments. RESULTS Six missense mutations in the coding region of the desmin gene that cause the substitution of an amino acid were identified in 11 patients (10 members of 4 families and 1 patient with sporadic disease); a splicing defect that resulted in the deletion of exon 3 was identified in the other patient with sporadic disease. Mutations were clustered in the carboxy-terminal part of the rod domain, which is critical for filament assembly. In transfected cells, the mutant desmin was unable to form a filamentous network. Seven of the 12 patients with mutations in the desmin gene had cardiomyopathy. CONCLUSIONS Mutations in the desmin gene affecting intermediate filaments cause a distinct myopathy that is often associated with cardiomyopathy and is termed "desmin myopathy. " The mutant desmin interferes with the normal assembly of intermediate filaments, resulting in fragility of the myofibrils and severe dysfunction of skeletal and cardiac muscles.
Preventing and treating nicotine addiction: a review with emphasis on adolescent health.

This article is the fourth in a series of four providing current, state-of-the-art information about the tobacco problem and how physicians can effectively intervene. The articles review the health effects of second-hand smoke, current treatment strategies for nicotine addiction and the implementation of best practices, such as the "5 As," to effectively intervene with families with smokers. Three of the articles are accredited for free continuing medical education (CME) credit for physicians. To obtain AMA PRA Category 1 Credit(s)TM for this article, please go online to www.PedsEducation. org, your source for free continuing medical education from Nemours. Choose "Online Education" and the article, and complete the post-test as directed. CME accreditation for this educational presentation is provided at no cost as a service of Nemours, one of the nation's largest children's health systems. Nemours is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Nemours designates this educational activity for a maximum of . 5 AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity. This article will focus on the prevention of adolescent smoking and discuss a global approach to the tobacco problem among youth. It also reviews the rationale for and pharmacology of treating nicotine addiction to empower physicians to assist smokers with quitting. By reading the article and completing the post-test, it is anticipated that the following learning objectives will be met: Physicians will become familiar with: 1) Options for treating nicotine addiction, 2) The unique aspects of the tobacco problem in adolescence, 3) The risk factors for teen smoking initiation.
Crude cacao theobroma cacao extract reduces mutagenicity induced by benzo[a]pyrene through inhibition of CYP1A activity in vitro

Polyphenols have been shown to have potent antioxidant activity, and therefore, food containing polyphenols is expected to contribute to the prevention of cancer. However, food contains not only polyphenols but also various other constituents. We used the Ames test to investigate the effects of crude extracts of whole cacao products, which are known to be rich in polyphenols, on the mutagenicity of benzo[a]pyrene (B[a]P) in Salmonella typhimurium strain TA 98 and tert‐butyl hydroperoxide (t‐BuOOH) in S. typhimurium strain TA 102. B[a]P induces mutagenicity by metabolic activation and t‐BuOOH induces it by generation of free radicals. While white chocolate did not modulate the numbers of revertant colonies produced by B[a]P treatment, milk chocolate and cacao powder extracts did. On the other hand, surprisingly, none of the cacao products tested affected the number of revertant colonies when t‐BuOOH was used as the mutagen. At maximum concentration (13.25 mg cacao powder/ml), the crude cacao powder extract reduced ethoxyresorufin O‐deethylase activity to 17.4% of the control, suggesting that whole cacao products inhibit cytochrome P450 (CYP) 1A activity. In conclusion, inhibition of CYP1A activity by cacao products may prevent DNA damage by reducing metabolic activation of carcinogens. Copyright © 2009 John Wiley & Sons, Ltd.
IW-Zinsausblick Oktober 2015. Niedriginflation: Eine Herausforderung für Zentralbanken

Niedrige Inflationsraten fordern die Geldpolitik der Europaischen Zentralbank (EZB) und der Federal Reserve Bank (Fed) heraus. Wahrend die wirtschaftliche Erholung der Eurozone immer noch schleppend verlauft, wachst die US-Wirtschaft robust und der US-Arbeitsmarkt verbesserte sich soweit Richtung Vollbeschaftigung, dass die Fed ein Ziel ihres dualen Mandats nun erfullt. Wahrend die US-Inflation immer noch niedrig ist, verhielt sich die Kerninflationsrate aber stabil. Eine Zinserhohung durch die Fed ist zu erwarten. Die effektive Federal Funds Rate von aktuell 0,14 Prozent erlaubt eine Ausweitung des Zielkorridors auf 0,25 bis 0,50 Prozent, ohne dass das Wirtschaftswachstum beeintrachtigt wurde. Eine Zinserhohung ware zudem ein star-kes Signal, dass die Fed die wirtschaftliche Erholung fur ausreichend befindet und dass sie eine Ruckkehr der Inflation zu ihren Zielwert im kommenden Jahr erwartet. Es ist aber aufgrund der niedrigen Inflationsrate wenig wahrscheinlich, dass die Fed in der ersten Halfte des kommenden Jahres ihren Leitzinskorridor noch einmal aus-weiten wird bzw. den traditionellen Durchschnittszielwert wiedereinfuhren wird. [. ]
The Loop System Between Neuropeptide Y and Leptin in Normal and Obese Rodents

Over the years, the work of research laboratories in Baton Rouge (USA), Seattle (USA) and Geneva (Switzerland) have reached analogous conclusions regarding the main etiology of obesity as studied in animals: it largely lies within the brain, notably within the hypothalamus. The hypothalamus is indeed known to modulate food intake and energy partitioning, while the periphery has also been proposed to feed-back on the central nervous system (CNS) to provide information on the state of body energy stores, the two together constituting a loop system connecting the brain to the periphery (1,2,3). This etiologic viewpoint of a pivotal role of the hypothalamus in obesity syndromes has been strengthened by the discovery of one hypothalamic neuropeptide and one peripheral (adipose tissue) hormone, respectively neuropeptide Y (4), and quite particularly, leptin (5). As neuropeptide Y produces hyperphagia (6, 7) and as leptin produces hypophagia in normal animals (8,9,10), the loop system just mentioned was thought to comprise functional relationships, at least between these two factors. Other evidence also suggested that such a loop system was altered in obese animals.