Miracle-dz/UniFAR-FTUs huggingface dataset:
Preprint Title Understanding the Role of Active Site Residues in CotB 2 Catalysis Using a Cluster Model

Terpene cyclases are responsible for the initial cyclization cascade in the multistep synthesis of a large number of terpenes. CotB2 is a diterpene cyclase from Streptomyces melanosporofaciens, which synthesizes the formation of cyclooctat-9en-7-ol, a precursor to the next-generation anti-inflammatory drug, cyclooctatin. In this work, we present evidence for a significant role of the active site residues in CotB2 on the reaction energetics using quantum mechanics calculations in an active site cluster model. The results using the active site model reveal the significant effect of the active site residues on the relative electronic energy of the intermediates and transition state (TS) structures with respect to gas phase data. A detailed understanding of the role of the enzyme environment on the CotB2 reaction cascade can provide important
The Effects of Preparation on Knee Frontal Plane Projection Angle During Landing Tasks in Female Athletes : A Study Protocol

Landing after the jump is a high risk mechanism that can be followed by numerous injuries of the lower extremity, especially in the knee. Lower limb injuries often are created in a condition that the person is not able to prepare for possible injury. Some studies have shown that appropriate and effective preparation during landing can reduce the injury risk. The present study aims to evaluate the effects of preparation on knee frontal plane projection angle (KFPPA) during landing tasks among the female athletes. In this cross-sectional study, 22 female recreational athletic activities will be selected using non-random sampling and measured KFPPA during the diverse landing tasks. Furthermore, all subjects will perform four common screening tasks as follows: the double leg drop landing and single leg drop landing for tasks with preparation; double leg jump landing and single leg jump landing for tasks without preparation. Several studies indirectly have investigated the influence of preparation on biomechanical factors of the lower extremity but direct impact of preparation has not been into consideration. Accordingly, the present study protocol will evaluate direct influence on the KFPPA during the landing in the recreational female athletes.
Expert Systems With Applications

Recommender systems were first introduced to solve information overload problems in enterprises. Over the last few decades, recommender systems have found applications in several major websites related to e-commerce, music and video streaming, travel and movie sites, social media, and mobile app stores. Several methods have been proposed over the years to build recommender systems. However, very little work has been done in recommender system evaluation metrics. The most common approach to measuring recommender system’s performance in offline settings is to employ micro or macro averaged versions of standard machine-learning measures. Profit or other business-oriented metrics have been proposed for other predictive analytics problems, such as churn prediction. However, no such metrics have emerged for the recommender system context. In this work, we propose a novel evaluation metric that incorporates information from the online-platform userbase’s behavior. This metric’s rationale is that the recommender system ought to improve customers’ repeated use of an online platform beyond the baseline level (i.e. in the absence of a recommender system). An empirical application of this novel metric is also presented in a real-world mobile app store, which integrates the dynamics of large-scale big data environments, which are common deployment scenarios for these types of recommender systems. The resulting profit metric is shown to correlate with the existing metrics while also being capable of integrating cost information, thereby providing an additional business benefit context, which allows us to differentiate between two similarly performing models.
QTLMapping of a High Protein Digestibility Trait in Sorghumbicolor

Compared with other cereal grains, Sorghum bicolor shows lower protein digestibility. The low digestibility is thought to result from disulfide cross linking in the βand γ-kafirins. In contrast, the single recessive high digestibility/high lysine content (HD) mutation which confers greater grain digestibility exists in sorghum that is thought to result from reduced accumulation of γkafirin that allows greater access to the high digestible α-kafarin fraction. In an effort to both clearly define the molecular basis for the HD trait and develop tools to improve the introgression of this difficult-to-screen trait, this study focuses on mapping the QTLs linked to this trait. While the HD trait has been defined as a single recessive gene, our results uncovered that two major QTLs on chromosome 1 are associated with protein digestibility—one QTL (locus 1 from the HD parent) unfavorably affects digestibility and one QTL (locus 2 from the HD parent) only 20 cM away favorably affects digestibility. A contrast analysis between genotypic groups at these two loci shows that a higher level of protein digestibility may be obtained when this linkage in repulsion is broken and favorable alleles are allowed to recombine.
Analysis of Nonstationary Stochastic Processes with Application to the Fluctuations in the Oil Price

CA 90089-1211 Carl von Ossietzky University, Institute of Physics, D-26111 Oldenburg, Germany Institute for Theoretical Physics, University of Münster, D-48149 Münster, Germany Department of Physics, Shahid Beheshti University, Evin, Tehran 19839, Iran Dep. of Physics, Sharif University of Technology, P.O. Box 11365-9161, Tehran 11365, Iran CNRS UMR 6529, Observatoire de la Côte d’Azur, BP 4229, 06304 Nice Cedex 4, France
Broadband time-domain impedance boundary modeling with the discontinuous Galerkin method for room acoustics simulations

The time-domain nodal discontinuous Galerkin (TD-DG) method is emerging as a potential wave-based method for three-dimensional (3D) room acoustics modeling, where high-order accuracy, geometrical flexibility and accurate modeling of boundary conditions are of critical importance. In this work, an accurate and efficient formulation of broadband time-domain impedance boundary conditions of locally-reacting surfaces is proposed in the framework of the TD-DG method. The formulation of the time-domain boundary condition is based on the plane-wave reflection coefficient at normal incidence and its approximation in the frequency domain using a sum of rational fractions, which can be obtained from analytical models or measured impedance values. To verify the performance of the formulation, a single reflection scenario is considered and the reflection coefficient obtained from the numerical tests is compared with the analytical one based on a locally reacting surface impedance. Also, the effects of the coefficients of rational functions on the accuracy are investigated. The broadband time-domain impedance boundary formulation accurately predicts both the amplitude and the phase of the reflection behaviour.
ANTIHYPERLIPIDEMIC EFFECT OF MIMUSOPS LARIFOLIA BUTANOLIC EXTRACT ON HIGH-FAT DIET-INDUCED OBESE RAT

Medicinal plants have been used since immemorial time to treat and prevent human ‎ailments. Mimusops Larifolia is a medium sized evergreen tree belonging to family ‎Sapotaceae which is widely used in the treatment of different ailments in traditional ‎system of medicine in ancient Egypt. Mimusops Larifolia species was recorded to have ‎several pharmacological activities like antimicrobial, antioxidant, anti-inflammatory, ‎hypotensive, antihyperlipidemic, antitumor as it possess a number of phytochemical ‎constituents which have been identified in this plant. Obesity is a significant risk factor ‎associated with many complications such as cardiovascular diseases, diabetes, ‎osteoarthritis, liver and kidney diseases, pancreatitis, cancer and chronic diseases. ‎ Obesity is a chronic disease that develops excessive fat accumulation and increase in ‎body weight and result in increased plasma triglycerides, high LDL cholesterol, low HDL ‎cholesterol, elevated blood glucose level and high blood pressure. High Fat Diet (HFD) ‎supplementation have been used in animal models to induce a significant increase in: serum cholesterol, triacylglycerol, , ‎ ‏ ‏ low density lipoprotein(LDL), ‎ ‏ ‏ lipoprotein ‏ ‏ a (Lip. A), ‎and increase activity of lipase enzymes On contrast, it exhibited a significant decrease in ‎serum levels of High density lipoprotein ‏ ‏ ‎(HDL). ‎ Mimusops laurifolia Leaves butanolic extract is selected for our investigation against ‎high fat dietinduced hyperlipidemia in rats as it was able to ameliorate stress induced by ‎high fat diet and showed pronounced curative effect aganist hyperlipidemia and ‎deviated serum atherogenic indices towards control levels. ‎ The results of the present study suggest that Mimusops laurifolia Leaves extract has the ‎potential to exert curative effect against hyperlipidemia. ‎
Evidence for gender responsive actions to promote well-being

The WHO Regional Office for Europe supports Member States in improving adolescent health by recommending comprehensive, multisectoral and evidence-informed adolescent health approaches; by delineating the critical contribution of the health sector; by fostering actions towards reducing inequalities; and by addressing gender as a key determinant of adolescent health. This publication aims to support this work in the framework of the European strategy for child and adolescent health and development, and is part of the WHO Regional Office for Europe contribution to the development of a new policy framework for Europe, Health 2020, for which the WHO Regional Office for Europe has been mandated by the 53 Member States. The publication summarizes current knowledge on what works in promoting the well-being of adolescents. It is part of a series that includes social and emotional well-being, chronic conditions and disabilities, adolescent pregnancy, HIV/STIs, overweight and obesity, violence, injuries and substance abuse. The publication assumes the position that young people’s health is the responsibility of the whole society, and that interventions need to be gender responsive in order to be successful. It therefore looks at actions at various levels, such as cross-sector policies, families and communities actions, and interventions by health systems and health services. The publication does not prescribe nor recommend any particular course of action, which needs to be informed by the country specific context. It rather provides a basis to stimulate countries to further refine national policies so that they contribute effectively to the health and well-being of young people.
Challenges and opportunities for sustainable livestock production in the UK

Summary Meat and milk production generally gets a bad press when it comes to discussions around climate change and food production. However, with a rising population, a balance has to be found between the environmental cost of producing and the benefits in terms of food security. Consequently, sustainable production is the byword. The beef, sheep meat, pig meat and dairy industries all have specific challenges in work to reduce their environmental impact. This paper examines some of these challenges, the research which has been undertaken into their scale, routes being exploited to improve efficiency and what gains have already been achieved. It also looks at some of the mitigating factors of dairy and livestock production that help mitigate any environmental costs and ensure we are making the most efficient use of available land.
AUTOMATED GENERATION , SELECTION AND EVALUATION OF ARCHITECTURES FOR ELECTROMECHANICAL ACTUATORS

The study presented in this paper has been conducted in the frame of the European project DRESS (Distributed and Redundant Electromechanical nose gear Steering System). The aim of this project is to develop and test an electrically powered nose gear steering system allowing automatic on-ground guidance. Giving the aircraft a true all-weather (true zero visibility) capability, it will hence offer significant aircraft operation gains and increase the Air Transport System efficiency. The reported work focuses on the design of the EMA replacing the current servohydraulic one, scaled to single aisle commercial aircrafts (see Figure 1). Towards the more electric aircraft, this challenging project must provide a technology step change, improving the system safety and reliability to allow automatic guidance by limiting the weight impact. Such a critical embedded electro-mechanical actuation system is very complex to design and to optimise, especially because of its multidisciplinary characteristic. The design of the power transmission, modulation and transformation must cope with multiple and antagonist constraints when considering mass, reliability, safety, shimmy damping, controllability, operability (towing) and so on.
Methods and applications of new technologies used for reducing of chemical usage and controlling of pests ( a review )

Initial low cost of pesticides and lack of knowledge on the part of agricultural producers has led to an overuse of pesticides, with dangerous consequences. On the other hand, today, pesticides have an important role in the increment of agriculture products. Therefore, in recent years, the major aims of agricultural, environmental and even the food industry researchers have been to reduce the usage of chemical materials in agricultural applications. To achieve this, variable rate application in sprayers using different technologies such as machine vision, ultrasonic sensors, spectrometry, laser scanning, as well as pest identification and classification, have been applied in recent studies. This paper reviews these works reported in the 21 century. In addition, the best result is suggested in the conclusion section for future studies.
Do we need different aircraft noise metrics to predict annoyance for different groups of people ?

In the literature, LAeq and Lden are the dominating noise exposure metrics for calculating the relationship between noise and annoyance. However, alternative metrics such as the number of events above a threshold (NAT), LAmax or Emergence are rarely considered, although they may have the potential to explain additional variance. This seems necessary because a WHO-Review pointed out that the average relationship between aircraft noise levels and annoyance raw scores is . 44 which represents an explained variance of only 19.36%. Here, we present a post-hoc analysis of the NORAH data set and aim to evaluate the adequacy of alternative noise metrics. We calculated regression models and multilevel analyses with robust estimation algorithms (MLR) by using different noise metrics (LAeq, Lden, LAmax, Emergence, NAT). The analyses were carried out for different groups of people (children, parents, teachers) and different contexts (school: workplace or learning environment, residential environment). The calculations with different noise metrics showed that the LAeq as a single noise metric can best predict annoyance. However, for aircraft noise annoyance of children and teachers there was a significant increase in explained variance by including the NAT criterion as a second noise metric in the models (maximum R2 = .684).
Mining and Ecotourism : Mining and Environmental Justice Community Network of South Africa and Others v Minister of Environmental Affairs and Others : An Analysis

In the recent case of Mining and Environmental Justice Community Network of South Africa and Others v Minister of Environmental Affairs and Others [2019] 1 All SA 491 (GP) the High Court of South Africa decided on a case brought by a coalition of eight civil society organisations. The Applicants challenged several authorisations, which led to the permission of an underground coal mine in the Mabola Protected Environment. The Mabola Protected Environment is located within southern Mpumalanga and is recognised as the site of some of the most sensitive and unique biodiversity in the country. The area is also a critically important and high yielding water catchment. The Mabola Protected Environment was declared on 22 January 2014 with the vision of developing the area for ecotourism development. Against this background, the aim of this paper is to analyse the judgement of the court in Mining and Environmental Justice Community Network of South Africa and Others v Minister of Environmental Affairs and Others and to locate its significance in the context of ecotourism. It will be argued that protected areas not only help protect our biodiversity, particularly our incredible wildlife and important natural ecosystems, but are also a key part of South Africa’s reputation as a global ecotourism destination. It is thus, crucial that government, as custodian of protected environments, effectively and diligently performs its crucial role of ensuring that declared protected environments are protected. The researcher concludes by submitting that ecotourism should be promoted in protected areas renowned for among others, their outstanding beauty and extraordinary ecological interest and that government should devise ways of returning the benefits to the local communities while supporting the protection of protected areas.
Occupancy-Based Energy Management and Campus Monitoring using Wireless Sensor Network

The economic growth of developing countries leads to a huge increase of energy use in buildings in large campus like universities and schools. A major source of high electricity consumption is careless usage of electricity. In most cases, building appliances systems run on fixed schedules and do not employ any control system based on detailed occupancy information. This paper presents the design and deployment of occupancy detection platform that can be used for accurate occupancy detection and electrical appliances such as lights, fans, air conditioners are controlled by considering the occupancy information and weather conditions. With the help of passive infrared sensor, infrared sensor, temperature sensor and humidity sensor, the low cost and easily deployable multi-sensor node based wireless sensor network is developed to achieve effective utilization of electrical energy and manpower. The system has been implemented in laboratories, class rooms and staffrooms of Sharda University, Greater Noida, India. The results show that approximately 10-19% power can be saved due to implementation of this wireless sensor module. The security of campus against intruders, moving in these areas after working hours, is also provided by this system. Index Term— Occupancy detection, Campus Monitoring, Wireless Sensor Network, Zigbee Protocol, Energy Saving, Low Cost, Multi-sensors Nodes
Evolution : Limited & Predictable or Unbounded & Lawless ?

In this brief commentary I compare and contrast two different views of evolution: one of limited (convergent) evolution and mathematical predictability, and one of unbounded diversity and no entailing laws. Clearly these opposing views cannot both be true at the same time. Their disagreement seems to rest on different underlying assumptions, and the challenge is to see if they can be reconciled.
PN populations in the local group and distant stellar populations

Abstract Our understanding of galactic structure and evolution is far from complete. Within the past twelve months we have learnt that the Milky Way is about 50% wider than was previously thought. As a consequence, new models are being developed that force us to reassess the kinematic structure of our Galaxy. Similarly, we need to take a fresh look at the halo structure of external galaxies in our Local Group. Studies of stellar populations, star-forming regions, clusters, the interstellar medium, elemental abundances and late stellar evolution are all required in order to understand how galactic assembly has occurred as we see it. PNe play an important role in this investigation by providing a measure of stellar age, mass, abundances, morphology, kinematics and synthesized matter that is returned to the interstellar medium (ISM). Through a method of chemical tagging, halo PNe can reveal evidence of stellar migration and galactic mergers. This is an outline of the advances that have been made towards uncovering the full number of PNe in our Local Group galaxies and beyond. Current numbers are presented and compared to total population estimates based on galactic mass and luminosity. A near complete census of PNe is crucial to understanding the initial-to-final mass relation for stars with mass >1 to <8 times the mass of the sun. It also allows us to extract more evolutionary information from luminosity functions and compare dust-to-gas ratios from PNe in different galactic locations. With new data provided by the Gaia satellite, space-based telescopes and the rise of giant and extra-large telescopes, we are on the verge of observing and understanding objects such as PNe in distant galaxies with the same detail we expected from Galactic observations only a decade ago.
Factors of Organizational Structures and Organization Size on the ERP Adoption System in Public Organization-Libya Context

Enterprise Resource Planning (ERP) system considered one of the information technology systems that encourage the organization to better future and has gained widespread fame in computer systems over the past years where it became a significant phenomenon in practice. Many kinds of research on ERP in many areas has been done in developed countries,while ERP adoption is still not enough of studies in developing countries especially in public organizations. The current study is exploratory insight regarding of identifying the factors of organization structure, organization size. That may affect the introduce ERP, by giving a brief explanation about Libyan public bodies based on causal research design; to explore the proposed conceptual framework which indicated in the literature review of current study depends on the theory of complexity.The suggestions show that these factors may significantly enhance ERP adoption for public organizations; for more facts can be investigated in proper future studies directions.
AN INFORMATION METRICS BASED LOW-RATE DDOS DEFENSE MECHANISM

A Distributed Denial-of-Service (DDoS) assault is a conveyed, extensive scale, facilitated assault on the accessibility of administrations of a given target framework or organize that is propelled in a roundabout way through numerous traded off registering frameworks. A less-value DD of Service assault is a shrewd assault is the aggressor will it send assault parcels on to casualty in an adequately less value to evade current peculiarity based location. A data metric can evaluate the distinctions of system movement with different likelihood circulations. In this paper, an inconsistency based methodology utilizing two new data measurements, for example, the summed up entropy metric of the data separation metric, to recognize less-value DD of Service assaults by calculating the distinction between honest to goodness movement and assault activity is proposed. The proposed data measurements (Generalized Entropy and Information Divergence) can adequately recognize lessvalue DD of Service assaults before and obviously decrease the negative rate. DD of Service assaults discovery metric is consolidated with IP traceback calculation to frame a compelling cooperative safeguard instrument against DD of Service assaults.