Miracle-dz/UniFAR-FTUs huggingface dataset:
Corticosteroid-induced osteoporosis in children: outcome after two-year follow-up, risk factors, densitometric predictive cut-off values for vertebral fractures.

OBJECTIVE To identify factors that contribute to a decreased Z score of volumetric spine bone mineral density (ZvSBMD) and the development of vertebral fractures (VF) in children receiving chronic systemic corticosteroid therapy (SCT); to describe their outcome after 2 years, and to define predictive threshold values for ZvSBMD for VF. METHODS Fifty-five children on SCT for >or= 6 months were prospectively followed for 2 years. In children with a ZvSBMD > -1.5, we prescribed preventive measures for osteoporosis and densitometry annually. In children with ZvSBMD <or= -1.5, we prescribed spine x-rays and those with VF received alendronate. The association between clinical and biochemical variables and the presence of VF or ZvSBMD were analyzed by logistic regression or multiple regression analysis. The threshold value of ZvSBMD for predicting VF was determined by ROC curve and the probability of having a VF was modeled by multiple logistic regressions. RESULTS Children who do not develop osteoporosis at first evaluation tend to maintain normal ZvSBMD after two years. Alendronate increased ZvSBM (median: at baseline: -2.69; 1 yr: -1.92; 2 years: -1.39, p < 0.001). The threshold value of ZvSBMD for predicting VF was -1.8. In this cohort, the risk of developing VF was significantly higher in children who were not ambulatory, growth retarded, treated with methotrexate for a longer time, had a family history of osteoporosis or were of non-aboriginal ancestry. CONCLUSION Children on SCT, who do not develop osteoporosis, tend to maintain normal BMD. Children who were not ambulatory, on methotrexate or growth retarded have higher rates of VF.
LeadMine : Disease identification and concept mapping using Wikipedia

LeadMine, a dictionary/grammar based entity recognizer, was used to recognize and normalize both chemicals and diseases to MeSH IDs. The lexicon was obtained from 3 sources: MeSH, the Disease Ontology and Wikipedia. The Wikipedia dictionary was derived from pages with a disease/symptom box, or those where the page title appeared in the lexicon. Composite entities (e.g. heart and lung disease) were detected and mapped to their composite MeSH IDs. For chemical-induced disease relationships we developed a simple patternbased system to find relationships within the same sentence. If none of our patterns matched the abstract, a heuristic was applied in which the most likely chemical/s were associated with all diseases. Diseases unlikely to be caused by a chemical were removed. The MeSH hierarchy was used to remove redundant relationships. Our system achieved F1-scores of 86.12%, for disease concept ID recognition, and 52.20% for chemical-induced disease relationships, on the test set.
More expertise for a better perspective: Task and strategy-driven adaptive neurofunctional reorganization for word production in high-performing older adults

ABSTRACT The suggestion that neurofunctional reorganization may contribute to preserved language abilities is still emerging in aging studies. Some of these abilities, such as verbal fluency (VF), are not unitary but instead rely on different strategic processes that are differentially changed with age. Younger (n = 13) and older adults (n = 13) carried out an overt self-paced semantic and orthographic VF tasks within mixed fMRI design. Our results suggest that patterns of brain activation sustaining equivalent performances could be underpinned by different strategies facing brain changes during healthy aging. These main findings suggest that temporally mediated semantic clustering and frontally mediated orthographic switching were driven by evolutive neurofunctional resources in high-performing older adults. These age-related activation changes can appear to be compatible with the idea that unique neural patterns expressing distinctive cognitive strategies are necessary to support older adults’ performance on VF tasks.
Isolation of environmental mycobacteria from clinical specimens in south-east England: 1973-1993.

SETTING A reference centre for tuberculosis bacteriology serving South-East England. OBJECTIVE The number of cultures of environmental mycobacteria (EM) submitted to regional and reference laboratories in the UK is increasing, and is adding considerably to the workload of these laboratories. The changing trends in the numbers and nature of EM submitted to the Dulwich Public Health Laboratory Regional Tuberculosis Centre (RTC), have been analysed to establish the nature of the increase. DESIGN This study is based on all cultures of EM submitted to RTC between 1973 and 1993. The cultures were grouped according to year of first isolation, number of isolates and data supplied by the client laboratories, including age and human immunodeficiency virus (HIV) status of the patients and the anatomical sites from which the mycobacteria were isolated. RESULTS A total of 9379 EM from 6668 patients was received. Single and multiple isolates were received, respectively, from 4681 and 1192 patients not known to be HIV positive and from 477 and 318 who were known to be HIV positive. The annual number of patients not known to be HIV positive with isolates of probable clinical significance increased steadily from less than 40 in 1973 to over 100 per year since 1990. Isolates of doubtful clinical significance also showed an increase over time. The annual numbers from HIV positive patients increased steeply following the first such isolates in 1984. CONCLUSIONS The data show that the annual number of isolates of EM from both HIV positive and negative patients is increasing both absolutely and relatively to isolates of Mycobacterium tuberculosis. This trend should be considered when planning the future scope and activities of mycobacterium reference laboratories, including the introduction of new DNA-based diagnostic methods.
Evaluting the object recognition in real-time process

Object recognition is one of the problems in computer vision and so many techniques have come up to solve. All of them employ machine learning, because the computer has to learn first and use it in future to say whether the query image matched or not. These proposes approaches for object recognition by applying scale and rotation invariant feature transform in an automatic segmentation algorithms like FAST, SURF, SIFT, ORB etc. The features should be discrete and stable so that it can be used for matching an object in different views. At first, an object is trained to find best features. The object can be recognized in the other images by using achieved feature points. The results should show that the proposed approach is reliable for object detection and should be robust to the noise.
Collapsing the layers: 6Stor, a scalable and IPv6-centric distributed storage system

The exponentially growing storage demands that industry currently faces puts a huge stress on traditional distributed storage systems. Indeed, the concurrently increasing quantity of available video content and video quality comes with a new set of challenges that existing distributed systems have a hard time to meet. These difficulties are mostly the result of design decisions that, while relevant for the initial scope of those systems, end up limiting their scalability. In this paper, a quick overview of these typical design decisions is presented for two examples: Ceph and GFS (Google File System). An original and IPv6-centric architecture is then described, that presents none of the aforementioned scalability limitations, and a first prototype of this architecture is compared to Ceph.
Bulk Forces and Interface Forces in Assemblies of Magnetized Pieces of Matter

When two magnets are stuck together, where do magnetic forces operate and which formulas should one apply to compute them? Such frequently asked questions do not find immediate answers in the literature on forces, mainly because the force field is obtained, by the Virtual Power Principle (VPP), as a (mathematical, vector-valued) distribution, not as a plain vector field, which would be more convenient for practical computation. We intend to show how to represent this single distribution by two vector fields, one of them borne by the bulk of the matter, the other one localized at material interfaces where discontinuities of permeability, of magnetization, etc., do occur. Suitable extensions of the classical Maxwell tensor play an important role in the computation (by the so-called “pillbox trick”) of this interface vector field.
The potential benefits of using fish oil in relation to preterm labor: the case for a randomized controlled trial?

From the Maternal Nutrition Group, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark, Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia, Princess Royal Maternity Hospital, Glasgow, UK, Department of Obstetrics and Gynecology, Hvidovre University Hospital, Copenhagen, Denmark and Holbæk Hospital, Holbæk, Denmark
Review Article: Addressing the sexual health of patients with COPD: the needs of the patient and implications for health care professionals

Sexual expression is an important part of our individual identity and yet, this area is rarely addressed by health professionals. This article will explore the possible reasons for this and will also demonstrate the importance of assessing sexuality in patients with chronic obstructive pulmonary disease (COPD). Chronic Respiratory Disease 2007; 4: 111—115
Necessity of secondary Syme amputation of the foot after severely destroyed hindfoot injury due to suicidal jump from height in a psychiatric patient: Case presentation and brief review of literature

A 44-year-old obese female (body mass index 37.2 kg/m2) presented with open severely destroyed injuries of her both hindfoots after a suicidal jump from approximately 4 m height out of her private balcony. There was a longstanding history of a psychiatric disorder (schizophrenia) treated by psychopharmaca. The left foot showed an open Gustilo-Anderson II hindfoot injury at the lateral aspect of calcaneus, and three-dimensional computed tomography (3D CT) revealed a highly comminuted hindfoot fracture-dislocation injury involving the calcaneus, the subtalar joint, and the Chopart joint (Figure 1A). The right foot showed an open Gustilo-Anderson IIIB hindfoot injury at the medial-plantar aspect of calcaneus, and 3D CT revealed a highly comminuted calacaneus fracture (Figure 1B).
Differential expression of chemokines and chemokine receptors in inflammatory periapical diseases.

BACKGROUND Periapical lesions are thought to be the result of a local inflammatory response mediated by inflammatory cell infiltration and production of inflammatory mediators. Although chemokines are strongly implicated in the migration and activation of leukocytes in different inflammatory diseases and experimental models, little is known regarding the expression of chemokines and their receptors in human apical periodontitis. OBJECTIVE AND METHODS The objective of this study was to determine the expression of chemokines and their receptors by real-time polymerase chain reaction in samples obtained from healthy gingiva, periapical granulomas, and inflammatory periradicular cysts. The inflammatory infiltrate was characterized by immunohistochemistry. RESULTS Comparing cysts and granulomas, an increase in CD4+ and CD8+ cells was observed in granulomas, despite the similar numbers of CD45RO-positive cells detected in both lesions. The analysis of mRNA expression revealed increased levels of CCR1, CCR2, CCR3, CCR5, CXCR1, and CXCR3 in both types of lesion compared with controls. Cysts exhibited a higher expression of CCR3, CCR5, CXCR1, and CXCR3 compared to granulomas. A significantly higher expression of RANTES, IP-10, and MCP-1 was detected in cysts compared with controls or granulomas. The expression of interleukin-8, MIP-1alpha, and MIP-1beta was not different in the three experimental groups. CONCLUSIONS The increase in Th1 type (CCR1, CCR5, and CXCR3) and Th2 type (CCR2 and CCR3) receptors in both periapical lesions suggests the concomitant occurrence of Th1 and Th2 responses. Furthermore, the prevalent expression of the receptors CCR3, CCR5, CXCR1, and CXCR3 and of the chemokines RANTES, IP-10, and MCP-1 in cysts may point to a role in the progression of granulomas to cysts.
KADIN ÇALIŞANLARIN TOPLUMSAL CİNSİYET ALGILARI VE İŞE ADANMIŞLIKLARI ARASINDAKİ İLİŞKİ

Toplumsal cinsiyet algisi bireylerin toplumdaki gorev, sorumluluk ve kendilerinden olan beklentileri belirleyen cinsiyet normlarina dayanir. Toplumsal cinsiyet algisi kadinlarin yasamin farkli alanlarindaki sorumluluklarini yerine getirmede kullandiklari referans olarak tanimlanmaktadir. Is yasami toplumsal cinsiyet algisinin etkin olarak hissedildigi bir alan olarak kadinlarin yasaminda bir yer kapsamaktadir. Calisanlarin adanmisliklarinin isletmenin performansini etkiledigi gozonune alindiginda isgucunun buyuk bir kismini olusturan kadin calisanlarin adanmislarinin toplumsal cinsiyet algisi tarafindan etkilenebilecegi dusunulmustur. Yayilim kurami (Spillover Theory) cercevesinde kurulan modelin arastirilmasi icin Sinop il ve ilcelerinde kamu ve ozel sektorde ucretli calisan kadinlardan olusan orneklem kullanilmistir. Orneklemden toplanan veriler bir istatistik programi ile analiz edilmistir. Regresyon sonuclarina gore toplumsal cinsiyet algisinin adanmisligi etkiledigi gorulmustur.
Open abdomen management of intra-abdominal infections: analysis of a twenty-year experience.

BACKGROUND No conclusive results on the efficacy and timing of open abdomen (OA) are available, particularly in the setting of intra-abdominal infections. We analyzed outcomes and risk factors retrospectively in a large series of patients managed with an OA during the past 20 y in an effort to clarify this issue. METHODS We reviewed the records of 133 patients who underwent treatment with an OA, considering factors related to patient, disease, medical management, and surgical treatment. The end points of the bi-variable analysis were 1-y mortality, calculated from the time of an initial OA procedure, and definitive fascial closure. RESULTS Most patients (112/133) managed with an OA had one of several types of peritonitis. Many patients had severe clinical conditions (mean Acute Physiology and Chronic Health Evaluation [APACHE] II score was almost 9 points for the study population). With regard to surgical management, the mean (+SD) number of abdominal revisions was 5.9+9.3 during a mean duration of treatment with an OA of 14.3+11.6 d. The overall mortality in the study was 26% (35/133). Bi-variable analysis revealed factors associated with overall mortality to be age, renal and respiratory co-morbidities, edema on an initial chest radiograph, blood pressure, blood glucose and creatinine concentrations; and APACHE II score. The rate of definitive fascial closure was 75% (100/133). Factors associated negatively with fascial closure were respiratory co-morbidity, edema on a first chest radiograph, post-operative mesenteric ischemia as an indication for OA, blood glucose and creatinine concentrations, and duration of an OA. CONCLUSIONS Patients' pre-operative clinical status influences strongly their response to surgical treatment. The management of OA does not affect adversely the survival of patients with intra-abdominal infections, but factors related to the management of OA (duration of OA) seem to affect the possibility of definitive fascial closure.
Comparing New Theory with Prior Beliefs: Market Civilization and the Democratic Peace

Stuart Bremer counseled against the falsificationist convention of testing new models against the null hypothesis of no model. Instead, new models should be compared against prior beliefs, and theories should compete, whenever possible, on a field of equivalent test conditions. This article applies Stuart Bremer's notion of comparative theory testing by comparing a new model of contract norms with the prior institutionalist model of democratic peace. On a field of equivalent test conditions it is found that the hypothesis for contract norms (that the democratic peace is contingent upon economic development) is thousands of times more likely to be true than the hypothesis for institutionalist theory (that democracy pacifies all dyads regardless of economic conditions). Democracy appears to be a significant force for peace only in dyads that are above the median income: the richest 45%. The results indicate that scholars of war should update the widespread prior belief that democracy, alone, causes peace.
Le mouvement naturaliste dans le cadre des relations littéraires entre la France et la Belgique francophone

Renaissance litteraire et naturalisme en Belgique. Appui doctrinal de L'Actualite a travers le monde et l'art et de L'Artiste a Zola et a ses disciples. Role joue par les editeurs belges dans la diffusion du naturalisme. C. Lemonnier et Zola. Cladel a Bruxelles| son influence sur l'eclosion d'un regionalisme belge. Le Theâtre-Libre d'Antoine a Bruxelles. Elaboration d'une langue qui fait une large part aux procedes impressionnistes de l'ecriture artiste: dereglement du materiel grammatical, distorsions syntadiques, manipulations lexicales.
New cause for false-positive results with the cryptococcal antigen test by latex agglutination

The highly specific and sensitive latex agglutination test for cryptococcal antigen detection in cerebrospinal fluid is routine in many hospitals. Contamination of cerebrospinal fluid by a minute amount of syneresis fluid (surface condensation) from agar gave a strongly positive reaction which was heat stable, was not eliminated by pronase treatment, and was not detected by the normal rabbit globulin controls. These observations were valid for three commercially available test kits and could represent a preventable cause of some unexplained false-positive tests despite the use of adequate controls.
Volatility and Asymmetric Effect of Random Shocks: A Comparison of Chinese and U.S. Stock Markets

This paper surveys the fields of relation between the stock returns and random shocks happened to the stock markets. We study the volatility of the returns in both Chinese stock market and U.S. stock market. We use GJR-GARCH model to measure the conditional variance of the stock return compared with the linear GARCH model, where we restrict the negative unconditional variance parameter bigger than the positive one with a dummy variable. We find the support from U.S. stock market that there exists asymmetric effect of random shocks on the stock return that the negative information gives much stronger effect than the positive one. But we didn't find evidence to support this hypothesis from Chinese stock market
Application of poly(acrylic acid) superporous hydrogel microparticles as a super‐disintegrant in fast‐disintegrating tablets

Poly(acrylic acid) superporous hydrogel (SPH) microparticles possessing a unique porous structure were used as a wicking agent to decrease disintegration time of fast‐disintegrating tablets (FDTs). The compression behaviour of poly(acrylic acid) SPH microparticles was evaluated using the Kawakita equation. Effects of various SPH microparticle sizes and a 19‐run fractional factorial design were evaluated. The factorial design was based on four factors consisting of ketoprofen, SPH microparticle, filler, and tableting pressure, and each factor contained three levels on the disintegration time and tensile strength of the prepared FDTs. The poly(acrylic acid) SPH microparticles existed in an amorphous state and swelled approximately 80‐times in distilled water and 50‐times in pH 6.8 0.2 m phosphate buffer. The compressibility of SPH microparticles increased significantly as the microparticle size increased. The FDTs made of SPH microparticles in the range of 75–106 μm showed the fastest disintegration time and higher tensile strength. SPH microparticle, tableting pressure and ketoprofen had significant effects on disintegration time and tensile strength of ketoprofen FDTs. The FDTs that were prepared with 2.5% w/w SPH microparticles of 75–106 μm at 63 MPa pressure possessed a tensile strength of 84.4+4.1 N cm−2 and disintegrated in 15.0+2.0 s. It was concluded that the poly(acrylic acid) SPH microparticles could serve as a good super‐disintegrant decreasing the disintegration time of FDTs.
Relação entre a nomeação automatizada rápida e velocidade de leitura em escolares com Dislexia e com Déficit Cognitivo

A nomeacao automatizada rapida (NAR) visa medir a velocidade com a qual se acessa as representacoes fonologicas e esta associada ao aprendizado da leitura. Com isso, o presente estudo tem por objetivo principal examinar a relacao entre a nomeacao automatizada rapida e velocidade de leitura em escolares com dislexia e naqueles que apresentam transtorno no aprendizado associado a atraso no desenvolvimento intelectual. Dessa forma, pergunta-se quais estimulos da tarefa de nomeacao estao associados a velocidade de leitura nestes grupos que, inicialmente, apresentam perfis semelhantes em desempenho na avaliacao de leitura. Participaram deste estudo, 54 escolares com queixa de dificuldade no aprendizado da leitura avaliados pelo projeto de pesquisa Ambulatorio de Transtornos da Lingua Escrita - diagnostico, acompanhamento e capacitacao profissional, da Universidade Federal do Rio de Janeiro. Participaram 26 escolares com dislexia, com idade entre 8 e 10 anos (M=8 anos e 7 meses; DP= 7 meses) e 28 com atraso no desenvolvimento cognitivo, da mesma faixa etaria (M= 8 anos e 5 meses; DP= 8 meses). Para os escolares com dislexia, foram significativas as correlacoes entre velocidade de leitura e a NAR letras. Ja para os escolares com atraso no desenvolvimento cognitivo, correlacionaram significativamente com a velocidade de leitura a NAR de objetos, cores, numeros e letras. E possivel observar que a nomeacao automatizada rapida esta associada a velocidade de leitura nos grupos clinicos estudados, entretanto, essa correlacao ocorre de maneira diferente. Tais evidencias trazem implicacoes clinicas e educacionais importantes de serem consideradas.
COMPARATIVE ANALYSIS OF AMERICAN AND SPANISH CRUISE PASSENGERS' BEHAVIORAL INTENTIONS

Earlier studies of cross-national differences in consumer behavior in different consumption sectors have verified that cultural differences have a strong influence on consumers. Despite the importance of cross-national analysis, no studies in the literature examine the moderating effects of nationality on the construction of behavioral intentions and their antecedents among cruise line passengers. This study investigates the moderating effects of nationality on the relationships between perceived value, satisfaction, trust and behavioral intentions among Spanish and (U.S.) American passengers of cruise lines that use Barcelona as home port and port-of-call. A theoretical model was tested with a total of 968 surveys. Structural equation models (SEMs) were used, by means of a multigroup analysis. Results of this study indicated that Spaniards showed stronger relationships between trust and behavioral intentions, and between emotional value and satisfaction. Americans presented stronger relationships between service quality and satisfaction, and between service quality and behavioral intentions.