Miracle-dz/UniFAR-FTUs huggingface dataset:
LncRNA NR027113 promotes malignant progression of gastric carcinoma via EMT signaling pathway.

OBJECTIVE The aim of this study was to explore the characteristics of long noncoding RNA (lncRNA) NR027113 in gastric carcinoma, and to further investigate whether it could promote the development of gastric carcinoma via epithelial mesenchymal transition (EMT) signaling pathway. PATIENTS AND METHODS Quantitative Real-time polymerase chain reaction (qRT-PCR) was performed to analyze the expression of NR027113 in 68 paired of gastric carcinoma and para-carcinoma tissues. Subsequently, the relationship between NR027113 expression and clinical indexes of gastric carcinoma as well as the prognosis of patients was analyzed. NR027113 expression in gastric carcinoma cells was detected by qRT-PCR as well. NR027113 knockdown model was constructed by lentivirus transfection in gastric carcinoma cells (including AGS and SGC-7901). Meanwhile, the effects of NR027113 on the biological functions of gastric carcinoma cells were analyzed by cell counting kit-8 (CCK-8), wound healing, transwell invasion and migration assay, respectively. Furthermore, the correlation between NR027113 and EMT signaling pathways was studied. RESULTS QRT-PCR results showed that the expression level of NR027113 in gastric carcinoma tissues was significantly higher than that of para-carcinoma tissues. Compared with patients with low expression of NR027113, the incidence of lymph node metastasis and distant metastasis was significantly higher in patients with high NR027113 expression. Meanwhile, the survival rate of patients with low NR027113 expression was significantly lower. Compared with control group, the invasion and migration abilities of cells in NR027113 knockdown group were significantly decreased. Subsequent qRT-PCR results demonstrated that the expression of EMT signaling pathway-related proteins was significantly changed after transfection of sh-NR027113. The above finding indicated that NR027113 could inhibit the malignant progression of gastric carcinoma. Moreover, the addition of transforming growth factor-β (TGF-β) cytokines synergistically promoted the malignant progression of gastric carcinoma with NR027113. CONCLUSIONS NR027113 expression was significantly increased in gastric carcinoma. Meanwhile, it was positively correlated with lymph node metastasis, distant metastasis and poor prognosis of gastric carcinoma patients. Furthermore, NR027113 could accelerate the invasion and migration abilities of gastric carcinoma cells via EMT signaling pathway.
A NOVEL mechanism for forecasting based on pattern recognition

Trend prediction is an attractive topic, because determining the buy and sell points is one of the most important issues for investors in the stock market. The main purpose of this paper is to find an effective mechanism to identify the buy and sell signals. Based on the principle of pattern recognition, we establish a novel mechanism to recognize up or down patterns and the pinpoint for buying or selling. Using all stocks listed on the US NASDAQ, which includes 4460 companies for the period Jan. 1st 2010 to Dec. 31th 2010, our empirical study examines the predictive power of our trading strategies. The results indicate that our new strategies are profitable and that the accuracy rate of our predictions is above 67%. The main contribution of our study is that we find the trend to be more important than the isolated price. We first propose the novel pattern of “uptrend” or “downtrend”, while a continuous unidirectional trend may forecast the uptrend or downtrend in the future, two continuous unidirectional trends could verify the uptrend or down trend. That is, when a stock is on the rise, there must appear continuous up lines on the chart, and if the stock is falling, two down lines appear. We named this strategy as the “Two-line Strategy”
Use of the National Early Warning Score (NEWS) to Identify Acutely Deteriorating Patients with Sepsis in Acute Medical Ward.

INTRODUCTION The National Early Warning Score (NEWS) is well established in acute medical units to identify acutely deteriorating patients and is shown to have good prognostic value. NEWS, however, has only been used in the Emergency Department as a triage tool. We aimed to evaluate the validity of NEWS in Acute Medical Ward (AMW) that treats predominantly acute infection-related conditions to the Internal Medicine service. MATERIALS AND METHODS We undertook a retrospective cohort study and analysed NEWS records of all patients admitted to AMW at Singapore General Hospital between 1 August 2015 and 30 July 2017. The outcome was defined as deterioration that required transfer to Intermediate Care Area (ICA), Intensive Care Unit (ICU) or death within 24 hours of a vital signs observation set. RESULTS A total of 298,743 vital signs observation sets were obtained from 11,300 patients. Area under receiver operating characteristic curve for any of the 3 outcomes (transfer to ICA, ICU or death) over a 24-hour period was 0.896 (95% confidence interval, 0.890-0.901). Event rate was noted to be high above 0.250 when the score was >9. In the medium-risk group (score of 5 or 6), event rate was <0.125. CONCLUSION NEWS accurately triages patients according to the likelihood of adverse outcomes in infection-related acute medical settings.
Exposure to Blast Overpressure Impairs Cerebral Microvascular Responses and Alters Vascular and Astrocytic Structure

Abstract Exposure to blast overpressure may result in cerebrovascular impairment, including cerebral vasospasm. The mechanisms contributing to this vascular response are unclear. The aim of this study was to evaluate the relationship between blast and functional alterations of the cerebral microcirculation and to investigate potential underlying changes in vascular microstructure. Cerebrovascular responses were assessed in sham- and blast-exposed male rats at multiple time points from 2 h through 28 days after a single 130-kPa (18.9-psi) exposure. Pial microcirculation was assessed through a cranial window created in the parietal bone of anesthetized rats. Pial arteriolar reactivity was evaluated in vivo using hypercapnia, barium chloride, and serotonin. We found that exposure to blast leads to impairment of arteriolar reactivity >24 h after blast exposure, suggesting delayed injury mechanisms that are not simply attributed to direct mechanical deformation. Observed vascular impairment included a reduction in hypercapnia-induced vasodilation, increase in barium-induced constriction, and reversal of the serotonin effect from constriction to dilation. A reduction in vascular smooth muscle contractile proteins consistent with vascular wall proliferation was observed, as well as delayed reduction in nitric oxide synthase and increase in endothelin-1 B receptors, mainly in astrocytes. Collectively, the data show that exposure to blast results in delayed and prolonged alterations in cerebrovascular reactivity that are associated with changes in the microarchitecture of the vessel wall and astrocytes. These changes may contribute to long-term pathologies involving dysfunction of the neurovascular unit, including cerebral vasospasm.
CORPORATE GOVERNANCE, MANAGERIAL COMPETENCES, ACCOUNTABILITY AND FINANCIAL PERFORMANCE OF COMMERCIAL BANKS IN UGANDA

The purpose of this study was to determine whether in Uganda, corporate governance, accountability and managerial competences are related with the financial performance of commercial banks. The motivation for this study was the poor performance of commercial banks in Uganda despite the number of interventions put in place. This study adopted a cross sectional and quantitative design where 25 commercial banks operating in Uganda were considered for the study. The study provides evidence that corporate governance, accountability, managerial competences significantly relate to financial performance of commercial banks in Uganda. However corporate governance was observed to be the most significant predictor of financial performance. The study recommends that corporate governance mechanisms should be put in place to enable the efficient and effective management of banks in Uganda in order to improve performance. The study contributes to dearth of existing literature on financial performance - largely focuses on corporate governance, accountability, managerial competences separately using Uganda’s experience.
ANTIBACTERIAL FIBERS BASED ON CELLULOSE AND CHITOSAN

Cellulose and chitin are the most abundant polysaccharides in nature. Chitin is the natural amino polysaccharide and is estimated to be produced annually almost as much as cellulose. These resources are renewable and inexhaustible if rationally utilised. Unique properties of chitin and chitosan (chitin derivative obtained by the deacetylation of chitin), such as antibacterial activity, biocompatibility, non-toxicity and bioresorptivity make these materials very suitable and important biomaterials. During our studies, we examined the possibilities of obtaining composite, biologically active cellulose-chitosan fibres. Аn effective two-stage procedure for obtaining antibacterial fibers based on cellulose and chitosan was developed. The first stage involves the formation of dialdehyde cellulose by potassium periodate oxidation of cellulose fibers, which is able to form Schiff’s base with chitosan. In the second stage, chitosan coated cellulose fibers were prepared by subsequent treatment of oxidized cellulose fibers with a solution of chitosan in aqueous acetic acid. Maximum percentage of chitosan introduced into/onto the cellulose fibers was 0,51 % (w/w). Antibacterial activity of cellulose fibers coated with chitosan as the active component against bacteria Escherichia coli and Staphylococcus aureus, was confirmed by in vitro experiments .
Historical development of derivatives’ underlying assets

The derivative transactions are able to eliminate the unexpected risk arising from the price volatility of the asset. The need for risk elimination relates to the application of derivatives.This paper is focused on derivatives’ underlying assets themselves. With the plain description, supported by progressive summarization, the authors analysed the relevant theoretical sources, dealt with derivatives, their underlying assets and their development in centuries. Starting in the ancient history, 2000 BC, the first non-standard transaction, very close to today’s understanding of derivatives, becomes to be closed between counterparties. During the time, in different kingdoms and emporiums, derivatives started to play a significant role in daily life, helping to reduce the uncertainty of the future. But the real golden era for derivatives started with the so called ‘New derivative markets’ and computer supported trading. They have extended their form from simple tools to most complex structures, without changing their main purpose hedging and risk – reduction.For the main purpose of this paper it is impossible to split the development of derivatives from the very wide extension of underlying assets. The change of these assets was one of the main drivers in derivatives development. Understanding of the dynamic character of these assets helps to understand the world of derivatives.
Interactive comment on “ Monitoring stable isotopes in caves over altitudinal gradients : fractionation behaviour and inferences for speleothem sensitivity to climate change ” by V

1. The description of the processes occurring inside the cave and on the speleothem surface (degassing of CO2, establishment of supersaturation with respect to calcite, calcite precipitation), their effect on carbon and oxygen isotope fractionation and their dependence on parameters such as temperature, superaturation with respect to calcite, drip rate, etc. is not entirely correct throughout the MS.
An Enhanced method for detecting obfuscated Javascript Malware using automated Deobfuscation

With the growth of Web services and the development of web exploit toolkits, web-based malware has increased dramatically. Using Javascript Obfuscation, recent web-based malware hide a malicious URL and the exploit code. Thus, pattern matching for network intrusion detection systems has difficulty of detecting malware. Though various methods have proposed to detect Javascript malware on a users' web browser, the overall detection is needed to counter advanced attacks such as APTs(Advanced Persistent Treats), aimed at penetration into a certain an organization's intranet. To overcome the limitation of previous pattern matching for network intrusion detection systems, a novel deobfuscating method to handle obfuscated Javascript is needed. In this paper, we propose a framework for effective hidden malware detection through an automated deobfuscation regardless of advanced obfuscation techniques with overriding JavaScript functions and a separate JavaScript interpreter through to improve jsunpack-n.
Tetrabenazine Facilitates Exocytosis by Enhancing Calcium-Induced Calcium Release through Ryanodine Receptors

Vesicular monoamine transporter-2 is expressed in the presynaptic secretory vesicles membrane in the brain. Its blockade by tetrabenazine (TBZ) causes depletion of dopamine at striatal basal ganglia; this is the mechanism underlying its long-standing use in the treatment of Huntington’s disease. In the frame of a project aimed at investigating the kinetics of exocytosis from vesicles with partial emptying of their neurotransmitter, we unexpectedly found that TBZ facilitates exocytosis; thus, we decided to characterize such effect. We used bovine chromaffin cells (BCCs) challenged with repeated pulses of high K+. Upon repeated K+ pulsing, the exocytotic catecholamine release responses were gradually decaying. However, when cells were exposed to TBZ, responses were mildly augmented and decay rate delayed. Facilitation of exocytosis was not due to Ca2+ entry blockade through voltage-activated calcium channels (VACCs) because, in fact, TBZ mildly blocked the whole-cell Ca2+ current. However, TBZ mimicked the facilitatory effects of exocytosis elicited by BayK8644 (L-subtype VACC agonist), an effect blocked by nifedipine (VACC antagonist). On the basis that TBZ augmented the secretory responses to caffeine (but not those of histamine), we monitored its effects on cytosolic Ca2+ elevations ([Ca2+]c) triggered by caffeine or histamine. While the responses to caffeine were augmented twice by TBZ, those of histamine were unaffected; the same happened in rat cortical neurons. Hence, we hypothesize that TBZ facilitates exocytosis by increasing Ca2+ release through the endoplasmic reticulum ryanodine receptor channel (RyR). Confirming this hypothesis are docking results, showing an interaction of TBZ with RyRs. This is consonant with the existence of a healthy Ca2+-induced-Ca2+-release mechanism in BCCs. SIGNIFICANCE STATEMENT A novel mechanism of action for tetrabenazine (TBZ), a drug used in the therapy of Huntington’s disease (HD), is described here. Such mechanism consists of facilitation by combining TBZ with the ryanodine receptor of the endoplasmic reticulum, thereby increasing Ca2+-induced Ca2+ release. This novel mechanism should be taken into account when considering the efficacy and/or safety of TBZ in the treatment of chorea associated with HD and other disorders. Additionally, it could be of interest in the development of novel medicines to treat these pathological conditions.
The acute effect of static and dynamic stretching during warm-ups on anaerobic performance in trained women

The purpose of this study was to investigate effects of static stretching, dynamic stretching and no stretching methods on power and speed in volleyball players. Therefore, Twenty-four volleyball players (height: 173.29 Â± 7.81 m; mass: 62.12 Â± 8.73 kg; age: 22.66 Â± 4.02 years; experience: 3.27 Â± 6.37) were tested for speed performance using the 20 meter sprint test and also for power using vertical jump test after static stretching, dynamic stretching and no stretching. The results analyzed using ANOVA showed that There was a significant increase in height jump after dynamic stretching against static stretching. But, there were no significant differences between no stretching and static stretching groups. In addition, there was a significant decrease in time 20 meter sprint after dynamic stretching against static stretching and no stretching groups. The results of this study suggest that it may be desirable for volleyball players to perform dynamic exercises before the performance of activities that require a high power output.
Polylactide/poly(hydroxybutyrate-co-hydroxyvalerate) blends: Morphology and mechanical properties

The morphology and the mechanical properties of polylactide/poly(hydroxybutyrate-co-hydroxyvalerate) blends of various compositions were studied. The statistical analysis of the scanning electron microscopy images allowed finding two statistical ensembles of the minor-phase particles. The first ensemble involves the dispersed particles, whereas the sec- ond one contains the coalesced particles. The mean diameters of both dispersed and coalesced minor-phase particles were calculated and plotted against the blend composition. Young's modulus, tensile strength, elongation at break, and Charpy impact strength of the blends were determined and examined as a function of the blend composition. The Young's modulus values were shown to be in accordance with theoretical predictions.
A Richer Understanding of Australia's Productivity Performance in the 1990s: Improved Estimates Based upon Firm-Level Panel Data

Australian industry is characterised by differences across firms, entry of new firms and exit of unsuccessful firms. These facts highlight the inappropriateness of measuring productivity using aggregate production functions based upon representative firms. In this study, we model heterogeneous firms which change over time. We model the interrelationship between productivity shocks, input choices and decisions to cease production. Firm-level data provides production function estimates for 25 two-digit Australian industries. A new aggregation method for industry-level data allows us to separate productivity changes from output composition changes. Our study sheds new light on the Australian productivity performance.
Adaptive Modeling of Urban Dynamics during Armada Event using CDRs

This study investigates the mobile phone data during ephemeral event (Armada). The statistical techniques have been used for modeling human mobility collectively and individually. The undertaken substantial parameters are: inter-event times, travel distances (displacements), and radius of gyration. They have been analyzed and simulated using computing platform by integrating various applications for huge database management, visualization, analysis, and simulation. Accordingly, the general population pattern law has been extracted. This study has revealed the individuals mobility in dynamic perspective for 615,712 mobile users, also the simulated observed data are classified according to (general, work, off) days.
The evolution of song in female birds in Europe

Bird song is usually regarded as an attribute of males. However, in some species, females may also produce songs even with comparable complexity to that of males. It has been suggested that female song may evolve due to similar selection pressures acting on males, but no study has yet investigated the evolution of female vocalization in a phylogenetic context, a gap that we intended to fill with this study. Based on standard descriptions in The Birds of Western Palearctic, we classified 233 European passerine species with respect to whether females are known to produce songs or not. We were more likely to find information on female song for species whose song is more studied than for less intensively studied species. When we traced information on female song on a phylogeny, we found that at least in 2 avian families, female song appeared to be the ancestral state, but such an ancestral state may be expected to be even deeper in the phylogenetic tree with increasing information on female song. In fact, we cannot exclude the possibility that the ancestor of European passerines had females capable of singing. In a preliminary comparative study based on the available data, we found some evidence that female song may have evolved under the influence of sexual selection as carotenoid-based dichromatism was positively related to female song among species. Our findings imply that due to publication bias, the evolutionary importance of female song is generally underestimated. Copyright 2007.
Parents’ Reasons for Sending Their Children to Bilingual Early Childhood Education

The importance of English has been widely acknowledged all around the world along with the global growth. To prepare young generation (children) with English, bilingual Early Childhood Education (ECE) has become trend in Indonesia society, there are many IndonesianEnglish bilingual ECE emerging in Indonesia. In this study, 36 parents of bilingual ECE students were given questionnaire investigating about their reasons for sending their children to an Indonesian-English bilingual ECE. This study revealed that parents’ concern are mostly on social and economic reasons, such the demand to be able to speak global language, prestige and pride, parents’ pretension to give future investment for children, and giving supportive language environment for children to socialize. Apart from the parents’ reasons above, the study suggests that in fact parents were not aware about the children’s ability in learning more than one language at the same time and the effect of being bilingual to the children’s cognitive development.
Technology Characteristics Effect toward Business Intelligence in Multinational Corporation

Business Intelligence (BI) are the arrangement of methodologies, procedures, applications, information, items, advances and specialized designs which are utilized to bolster the accumulation, examination, presentation and dispersal of business data. BI advancements give verifiable, present and prescient perspectives of business operations. Normal elements of business insight innovations are reporting, online investigative preparing, examination, information mining, handle mining, complex occasion handling, business execution administration, benchmarking, content mining, prescient examination and prescriptive examination and are fit for taking care of a lot of organized and here and there unstructured information to distinguish, create and generally make new key business openings. The frameworks that support BI arrangements are altogether different from different in the organization. All around composed BI frameworks are versatile by nature; they constantly change to answer new and distinctive business questions. What's more, the most ideal approach to adjust successfully is to begin little and develop naturally. Each new addition refines and expands the arrangement, changing in accordance with client input and new necessities. Like a sprawling redwood woodland, the best BI arrangements take years to develop, extending in broadness and profundity after some time. It is no fortuitous event that the estimation of a BI arrangement develops exponentially with the quantity of clients and applications it supports. This study adopts DOI theory as a theoretical basis firstly because it is a well-established theory and is widely used in information technology diffusion-related research. Very limited research has been pointed at detecting foundations of innovation and the incorporation of innovation insights from a knowledge-based standpoint, particularly BI systems. This review will include quantitative techniques to examine components impelling the selection of business intelligence and decision support applications. This study focused on ERP user in Multinational Corporations in Malaysia. The quantitative data that gained from the questionnaire are analyzed by using different analytical techniques. The analysis of data in this study was by using the Smart PLS3. The methods of data analysis are selected based on the research questions and the variable characteristics.