Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical and Demographic Characteristics of Patients With a New Diagnosis of Carriage or Clinical Infection With Carbapenemase-Producing Enterobacterales: A Retrospective Study

Background: To examine the clinical, demographic, and microbiologic characteristics of new rectal carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) carriers vs. those with a clinical infection, hospitalized at Padeh-Poriya Medical Center between 2014 and 2017 and to examine the susceptibility profiles of isolates from clinical infections. Methods: In this retrospective, chart analysis, demographic and clinical data were collected from medical charts of 175 adult patients with either new- onset carbapenemase-producing Enterobacterales (CPE) carriage or clinical CPE infection. Collected data included age, ethnic group, place of residence, hospitalizations in the past 90 days, and 30-day mortality. Microbiological analyses considered bacterial genus, molecular resistance mechanism and antibiotic susceptibility. Results: A significantly higher percentage (42.4%) of CPE carriers were long-term care facility residents, and had been recently hospitalized (56.3%), as compared to patients with clinical CPE infection (29.2 and 45.9%, respectively). Additionally, we noted a high (58.3%) acquision of CPE in our hospital. The most common bacterial isolate was K. pneumoniae and the most common resistance mechanism was Klebsiella pneumoniae (K. pneumoniae) carbapenemases (KPC). High susceptibility rates to amikacin and chloramphenicol were also noted. Conclusions: This study reaffirmed the importance of CPE screening and infection control measures. The observed antibiotic susceptibility profile suggests amikacin and chloramphenicol as potential treatments for CPE infection.
Editorial Review Board

The study examined some important demographic correlates such as, age, education, social category, year of experience, husband's and parents' education, previous occupation, and present occupation, family's income, membership in associations and training of locus of control of 32 women entrepreneurs in two metro cities in India. Locus of Control Scale (Rao, 1985), self-constructed scale to measure perceptions of present ladder of success and success rate were used for the present study. Results on Pearson's correlations revealed that a majority of women entrepreneurs had internal perceptions about taking up a challenging task and success in it. Only age had significant and positive correlation with locus of control. Perceptions of ladder of success at present had significant inverse correlations with father's previous and present occupation and significant positive correlations with success rate perceived by women entrepreneurs.
Soil Texture, Sampling Depth and Root Hairs Shape the Structure of ACC Deaminase Bacterial Community Composition in Maize Rhizosphere

Preservation of the phytostimulatory functions of plant growth-promoting bacteria relies on the adaptation of their community to the rhizosphere environment. Here, an amplicon sequencing approach was implemented to specifically target microorganisms with 1-aminocyclopropane-1-carboxylate deaminase activity, carrying the acdS gene. We stated the hypothesis that the relative phylogenetic distribution of acdS carrying microorganisms is affected by the presence or absence of root hairs, soil type, and depth. To this end, a standardized soil column experiment was conducted with maize wild type and root hair defective rth3 mutant in the substrates loam and sand, and harvest was implemented from three depths. Most acdS sequences (99%) were affiliated to Actinobacteria and Proteobacteria, and the strongest influence on the relative abundances of sequences were exerted by the substrate. Variovorax, Acidovorax, and Ralstonia sequences dominated in loam, whereas Streptomyces and Agromyces were more abundant in sand. Soil depth caused strong variations in acdS sequence distribution, with differential levels in the relative abundances of acdS sequences affiliated to Tetrasphaera, Amycolatopsis, and Streptomyces in loam, but Burkholderia, Paraburkholderia, and Variovorax in sand. Maize genotype influenced the distribution of acdS sequences mainly in loam and only in the uppermost depth. Variovorax acdS sequences were more abundant in WT, but Streptomyces, Microbacterium, and Modestobacter in rth3 rhizosphere. Substrate and soil depth were strong and plant genotype a further significant single and interacting drivers of acdS carrying microbial community composition in the rhizosphere of maize. This suggests that maize rhizosphere acdS carrying bacterial community establishes according to the environmental constraints, and that root hairs possess a minor but significant impact on acdS carrying bacterial populations.
Suicide in DSM-5: Current Evidence for the Proposed Suicide Behavior Disorder and Other Possible Improvements

Suicide continues to be one of the greatest challenges faced by mental health clinicians and researchers, an issue made worse by increasing trends in the global suicide rate. Suicide behavior disorder (SBD) was introduced in DSM-5 as a disorder for further consideration and potential acceptance into the diagnostic system. There are numerous positive developments that would arise from the addition of a suicide-related diagnosis. Utilizing the 2009 guidelines established by Kendler and colleagues, the present review examines the evidence for SBD's validity and discusses the diagnosis' potential clinical benefits and limitations. Altogether, growing evidence indicates that SBD has preliminary validity and benefit. SBD presents with several significant limitations, however, and possible alternative additions to future DSMs are highlighted.
Elicitation of Highly Pathogenic Avian Influenza H5N1 M2e and HA2-Specific Humoral and Cell-Mediated Immune Response in Chicken Following Immunization With Recombinant M2e–HA2 Fusion Protein

The study was aimed to evaluate the elicitation of highly pathogenic avian influenza (HPAI) virus (AIV) M2e and HA2-specific immunity in chicken to develop broad protective influenza vaccine against HPAI H5N1. Based on the analysis of Indian AIV H5N1 sequences, the conserved regions of extracellular domain of M2 protein (M2e) and HA2 were identified. Synthetic gene construct coding for M2e and two immunodominant HA2 conserved regions was designed and synthesized after codon optimization. The fusion recombinant protein (~38 kDa) was expressed in a prokaryotic system and characterized by Western blotting with anti-His antibody and anti-AIV polyclonal chicken serum. The M2e–HA2 fusion protein was found to be highly reactive with known AIV-positive and -negative chicken sera by ELISA. Two groups of specific pathogen-free (SPF) chickens were immunized (i/m) with M2e synthetic peptide and M2e–HA2 recombinant protein along with one control group with booster on the 14th day and 28th day with the same dose and route. Pre-immunization sera and whole blood were collected on day 0 followed by 3, 7, 14, 21, and 28 days and 2 weeks after the second booster (42 day). Lymphocyte proliferation assay by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method revealed that the stimulation index (SI) was increased gradually from days 0 to 14 in the immunized group (p < 0.05) than that in control chicken. Toll-like receptor (TLR) mRNA analysis by RT-qPCR showed maximum upregulation in the M2e–HA2-vaccinated group compared to M2e- and sham-vaccinated groups. M2e–HA2 recombinant protein-based indirect ELISA revealed that M2e–HA2 recombinant fusion protein has induced strong M2e and HA2-specific antibody responses from 7 days post-primary immunization, and then the titer gradually increased after booster dose. Similarly, M2e peptide ELISA revealed that M2e–HA2 recombinant fusion protein elicited M2e-specific antibody from day 14 onward. In contrast, no antibody response was detected in the chicken immunized with synthetic peptide M2e alone or control group. Findings of this study will be very useful in future development of broad protective H5N1 influenza vaccine targeting M2e and HA2.
In-Depth Analysis of the Impact of Different Serum-Free Media on the Production of Clinical Grade Dendritic Cells for Cancer Immunotherapy

Dendritic cell (DC)-based antitumor vaccines have proven to be a safe approach, but often fail to generate robust results between trials. Translation to the clinic has been hindered in part by the lack of standard operation procedures for vaccines production, namely the definition of optimal culture conditions during ex-vivo DC differentiation. Here we sought to compare the ability of three clinical grade serum-free media, DendriMACS, AIM-V, and X-VIVO 15, alongside with fetal bovine serum-supplemented Roswell Park Memorial Institute Medium (RPMI), to support the differentiation of monocyte-derived DCs (Mo-DCs). Under these different culture conditions, phenotype, cell metabolomic profiles, response to maturation stimuli, cytokines production, allogenic T cell stimulatory capacity, as well as priming of antigen-specific CD8+ T cells and activation of autologous natural killer (NK) cells were analyzed. Immature Mo-DCs differentiated in AIM-V or X-VIVO 15 presented lower levels of CD1c, CD1a, and higher expression of CD11c, when compared to cells obtained with DendriMACS. Upon stimulation, only AIM-V or X-VIVO 15 DCs acquired a full mature phenotype, which supports their enhanced capacity to polarize T helper cell type 1 subset, to prime antigen-specific CD8+ T cells and to activate NK cells. CD8+ T cells and NK cells resulting from co-culture with AIM-V or X-VIVO 15 DCs also showed superior cytolytic activity. 1H nuclear magnetic resonance-based metabolomic analysis revealed that superior DC immunostimulatory capacities correlate with an enhanced catabolism of amino acids and glucose. Overall, our data highlight the impact of critically defining the culture medium used in the production of DCs for clinical application in cancer immunotherapy. Moreover, the manipulation of metabolic state during differentiation could be envisaged as a strategy to enhance desired cell characteristics.
Prevalence of Cardiovascular Disease and Associated Factors Among Type 2 Diabetes Patients in Selected Hospitals of Harari Region, Eastern Ethiopia

Background: Cardiovascular disease (CVD) is the most prevalent complication and the leading cause of death among patients with diabetes mellitus (DM). Type 2 diabetes mellitus (T2DM) patients have a 2- to 4-fold increased risk of CVD. There is a scarcity of data about the magnitude of CVD among patients with diabetes in Ethiopia. This study aimed to assess the prevalence and associated factors of CVD among T2DM patients at selected hospitals of Harari regional state of Ethiopia. Methods: This hospital-based retrospective data review was conducted among T2DM patients on follow-up in the diabetes clinics of selected hospitals of Harari regional state. The records of T2DM patients who have been diagnosed between January 1, 2013, and December 31, 2017, were reviewed from March to April 2018. Data were collected by using structured checklists from all necessary documents of T2DM patients. Statistical analysis was done using STATA 14.1. Bivariate and multivariate logistic regressions were used to identify factors associated with CVD. Result: The records of 454 T2DM patients were extracted from three government hospitals in Harari regional state. Their age was ranging from 15 to 86 years with a mean age (±SD) of 45.39 (14.76). The overall prevalence of CVD among T2DM patients was 42.51%, composed of hypertensive heart diseases (38.99%), heart failure (6.83%), and stroke (2.20%). The final multivariate logistic regression model revealed that age older than 60 years [adjusted odds ratio (AOR) = 3.22; 95% CI: 1.71–6.09], being physically inactive (AOR = 1.45; 95 CI: 1.06–2.38), drinking alcohol (AOR = 2.39; 95% CI: 1.17–6.06), hypertension (AOR = 2.41; 95% CI: 1.52–3.83), body mass index >24.9 kg/m2 (AOR = 1.81; 95% CI: 1.07–3.07), and experiencing microvascular diabetic complications (AOR = 3.62; 95% CI: 2.01–6.53) were significantly associated with the odds of having CVD. Conclusion: The prevalence of CVD was high and associated with advanced age, physical inactivity, drinking alcohol, higher body mass index, hypertension, and having microvascular complications. Health care workers should educate T2DM patients about healthy lifestyles like physical activity, weight reduction, blood pressure control, and alcohol secession, which can reduce the risk of CVD.
Multimedia Gloss Presentation: Learners' Preference and the Effects on EFL Vocabulary Learning and Reading Comprehension

Drawing on Moreno's cognitive-affective theory of learning with media, this research aims to investigate the effectiveness of different multimedia glosses on learners' vocabulary acquisition and reading comprehension in a CALL environment. A total of 160 university students who learnt English as a foreign language (EFL) in four classes participated in the study and were exposed to one of the four conditions: (a) L2 definition only, (b) L2 definition coupled with audio, (c) L2 definition plus video, and (d) L2 definition with picture. Participants were asked to read eight hypermediated reading texts. Reading comprehension as well as vocabulary acquisition were measured using a pretest–posttest design. The results show first that all these four conditions led to students' vocabulary gains. More specifically, participants who had access to L2 definition plus picture and plus videos achieved significantly higher scores than the other two groups, L2 definition coupled with audio and L2 definition only. Concerning reading comprehension, all multimedia glossing presentation led to better reading comprehension, but no differences were found among all the glossing groups. The questionnaire and interview data indicate that students preferred L2 definition coupled with video and picture glosses, followed by audio and L2 definition only. The results reflect that multimedia glossing presentation creates a different effect on students' vocabulary acquisition and reading comprehension, respectively. They also provide pedagogical implications for learning in times of COVID-19.
Differentially Oblivious Turing Machines

Oblivious RAM (ORAM) is a machinery that protects any RAM from leaking information about its secret input by observing only the access pattern. It is known that every ORAM must incur a logarithmic overhead compared to the non-oblivious RAM. In fact, even the seemingly weaker notion of diﬀerential obliviousness, which intuitively “protects” a single access by guaranteeing that the observed access pattern for every two “neighboring” logical access sequences satisfy ( (cid:15), δ )-diﬀerential privacy, is subject to a logarithmic lower bound. In this work, we show that any Turing machine computation can be generically compiled into a diﬀerentially oblivious one with only doubly logarithmic overhead. More precisely, given a Turing machine that makes N transitions, the compiled Turing machine makes O ( N · log log N ) transitions in total and the physical head movements sequence satisﬁes ( (cid:15), δ )-diﬀerential privacy (for a constant (cid:15) and a negligible δ ). We additionally show that Ω(log log N ) overhead is necessary in a natural range of parameters (and in the balls and bins model). As a corollary, we show that there exist natural data structures such as stack and queues (supporting online operations) on N elements for which there is a diﬀerentially oblivious implementation on a Turing machine incurring amortized O (log log N ) overhead per operation, while it is known that any oblivious implementation must consume Ω(log N ) operations un-conditionally even on a RAM. Therefore, we obtain the ﬁrst unconditional separation between obliviousness and diﬀerential obliviousness in the most natural setting of parameters where (cid:15) is a constant and δ is negligible. Before this work, such a separation was only known in the balls and bins model. Note that the lower bound applies in the RAM model while our upper bound is in the Turing machine model, making our separation stronger.
Recovery of 14C from Graphite Moderator of Gas-Cooled Reactor (GCR)

The chemical exchange method of carbon isotopes between CO2 and carbamate was applied to the recovery of 14C from 1,6001 graphite moderator of a gas-cooled reactor (GCR), Tokai-1, and the dimensions of 14C-enrichment process were evaluated numerically. Applicability of two processes with different operation modes, continuous process and batch process, was discussed under the conditions that the concentration of 14CO2 in the stripped flow corresponding to 99% of feed CO2 is less than the environmental standard. For the continuous process using 2mol/l diethylamine (DEA)-octane solution as a working fluid at—20°C and 0.2 MPa, the column dimensions were evaluated as 3.2 m in diameter and 5.7 m in height in the case of operating period of 20 yr. For the batch process using 4 mol/l DEA-octane solution, the column dimensions were comparable to those of continuous process, when the process was operated at the rate of 4 batch/month under the conditions of—20°C and 0.3 MPa. From these results, it is concluded that the CO2/carbamate exchange method is applicable to the recovery of 14C from irradiated graphite. However, the batch process has serious disadvantages, such as large energy consumption to maintain the top reservoir at low temperature and the generation of a large quantity of secondary wastes. At the present stage, the continuous process should be selected for the practical process design.
Theory of defect superlattices in crystals with application to void/vacancy and nitrogen interstitial lattices in tantalum and vanadium

An elastic interaction theory is proposed for the formation of a regular array of substitutional or interstitial defects-the defect superlattice-in a crystal. A Green function method is described for the calculation of the formation energy of a defect superlattice. The theory predicts the formation of a void/vacancy lattice in tantalum and vanadium with the ratio of the void lattice constant to the void radius as eight for both the metals and a lattice of nitrogen interstitials at octahedral sites in tantalum and vanadium with the equilibrium concentration of nitrogen per host atom at 1/64 in tantalum and 1/16 in vanadium. Agreement with the experimental observations where available, namely, the void lattice in tantalum and the nitrogen lattice in vanadium, is good.
Courting Shareholders: The Ethical Implications of Altering Corporate Ownership Structures

ABSTRACT: The relationship between corporate executives and shareholders has riveted the attention of business ethicists since the inception of the field. Most ethicists agree that corporate executives owe their investors the duties of loyalty, candor, and care. These fiduciary duties undergird the promises made to shareholders at the time of incorporation, placing on executives moral obligations to engage in fair dealing and to avoid conflicts of interest. We concur that executives owe all of their existing shareholders both promise-keeping and fiduciary duties and argue that some corporate executives violate these responsibilities by attempting to withhold information from or limit information to some shareholders while courting others. We analyze the ethical implications of six techniques and tools that executives use to attract certain types of shareholders while deterring others. We conclude with recommended structural and behavioral changes to these current managerial and investor practices.
Pottery and Politics: Making Sense of Pottery Traditions in Central Africa

The multiscalar analysis of pottery traditions in south central Africa opens a new perspective on the study of ancient polities. Focusing on an area of central Africa known for the existence of great kingdoms, I show how past political entities have left lingering traces in the cultural landscape and, more specifically, in the pottery traditions. As ceramics are one of the major tools in the archaeological arsenal, the way they can be related to political structures is of interest to archaeologists around the world. Analysing the chaîne opératoire of living pottery traditions, at an individual and regional level, I characterize the geographic extent of a series of technical behaviours. These technical domains fit with other aspects of society such as languages or matrimonial strategies, but also with economic and political aspects such as salt making and distribution networks and past political entities. They are the materialization of resilient social spaces created by ancient political entities.
Tight-Binding Calculation of Electronic Structures of InNAs Ordered Alloys

The electronic structure of InNx As1-x ordered alloys (x=0.25, 0.5 and 0.75) are calculated based on a semi-empirical tight-binding method. The alloy is found to have direct band gaps throughout the entire composition range. The band-gap bowing parameter c in E g=0.36+1.53x+cx(x-1) eV of the alloy InNx As1-x is larger with larger valence-band discontinuity between InAs and InN, and is 4.22 eV if a theoretical value of 3.79 eV given by Harrison's theory is assumed.
Synthesis and Properties of Indan-Based Polyacetylenes That Feature the Highest Gas Permeability among All the Existing Polymers

Acetylenic monomers containing indan and other groups (1a−m) were polymerized with TaCl5-n-Bu4Sn catalyst to give high molecular weight polymers. Most polymers were soluble in common organic solvents including toluene and chloroform, and they afforded free-standing membranes by the solution casting method. The onset temperature of weight loss of the polymers were over 400 °C, indicating high thermal stability. Despite the absence of bulky spherical groups, polymethylated indan-containing polymer membranes showed extremely high gas permeability. In particular, the oxygen permeability coefficients of polymers having 1,1,3,3-tetramethylindan and either p-fluorophenyl or p,m-difluorophenyl groups (2b and 2e) reached 17 900 and 18 700 barrers, respectively, which are even larger than that of the most permeable polymer known, poly(1-trimethylsilyl-1-propyne).
Magnetic domains in rolled-up nanomembranes of Co/Pt multilayers with perpendicular magnetic anisotropy

Compact rolled-up nanomembranes of high quality (111)-oriented Co/Pt multilayers with perpendicular magnetic anisotropy are realized by combining strain engineering with top-down preparation methods. Magnetic force microscopy analyses were performed in the demagnetized state and under magnetic fields applied on rolled-up Co/Pt tubes. Observed magnetic domains are composed of radially polarized stripe-shaped domains. The stripes running along the rolled-up tubes axis are observed for magnetic fields applied along this direction, whereas a salmon-like pattern is observed for magnetic fields applied along the tube diameter. Present results indicate potential for applications as magnetic encoders and servo motors.
Managing Intuition

with organizations; the solution, however surprising, was to link employees to the leaders of the group. The leader, practicing self-awareness and self-monitoring, could become a model of both how to deal with one’s frustrations and how not to criticize the corporation but instead find fault with oneself. Burnout thus became, to a large extent, a humanistic management tool—one for managing managers and that could, in turn, manage the group. It ensured that employees would accept their inherent conflict with the organization but work diligently to become integrated with it; by following the leader, an employee could both work for the group and be an individual. If burnout became an issue in the 1970s because of a genuine concern about conflict between the individual and the organization, by the 1980s burnout became popular because of its utility as a management tool, convincing executives—and by extension, their subordinates—to practice self-monitoring, self-assessment, and self-therapy for their own benefit and that of the corporation.