Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone Microenvironment and Role of Rank-Rankl-Opg in Breast Cancer Metastasis in Bone

Bone metastasis affects more than 70% of advanced breast cancer patients and is the leading cause of breast cancer-related deaths, incapable of being controlled, still very unpredictable. As a consequence, this has led to increased mortality and worsen quality of life in these patients by causing severe complications such as excruciating bone pain, hypercalcemia and spinal cord compression, pathological fractures also known as skeletal related events (SRE). Vast majority of breast cancer patients with relapses in bone are asymptomatic during the course of the disease, hence making it difficult to diagnosis and detect the spread of the breast cancer cells to the bone prior to appearance of bone pain complains issued by this category of patients. Due to increased frequency of bone metastases in breast cancer during the recent years, understanding cross-communications between tumor cells and bone cells accompanied by the action of various growth factors, proinvasive cytokines, chemokines released upon bone destruction are essential to help improve the development of new effective therapeutic interventions. The pathogenesis of bone metastases in breast cancer depends on the bidirectional tight interaction among breast cancer cells and various stromal cells also being identified as the “vicious cycle”, which modulates the bone niche resulting in continuous activation of bone resorption process. One of the major important pathways involved in the development and progression of bone metastases in breast cancer is RANK-RANKL-OPG cascade, where a positive shift towards RANKL-RANK axis favors proliferation, activation and survival of osteoclasts, thus promoting tumorigenesis and metastasis in the bone. In this context, disturbance of RANKL-RANK interplay should be an effective method to prevent the survival and growth of the breast cancer cell in the bone microenvironment.
Variations in Platelet Count and Total Protein in Relation to Differences in Sex, Age, Breed and Reproductive Status of Goats during the Cold-Dry Season (Harmattan)

This study aimed at evaluating the effect of sex, age, breed and reproductive status on platelet count and total protein, and also to demonstrate the relationship between the two variables in goats during the cold-dry season. At the peak of the cold-dry season, 56 male and female goats belonging to Red Sokoto (n = 28) and Sahel (n = 28) as well as 14 Red Sokoto goats in the last trimester of gestation (n = 7) and early lactation (n = 7) were sampled and results statistically analysed. The results revealed that the platelet count was significantly (P<0.05) higher in kids, bucks, Red Sokoto and pregnant goats, while blood total protein was significantly lower (P<0.05) in kids, bucks, Red Sokoto and pregnant goats. In addition to this inverse relationship, a significantly negative correlation (P < 0.005; r=-0.330) was observed between platelet and blood total protein. It was concluded that sex, age, breed and reproductive status markedly influenced platelet count and blood total protein in an inverse manner with a negative correlation between the two variables in goats exposed to a season with low ambient temperature. More studies are needed to directly establish and understand the relationship between platelet count and blood total protein on exposure to low ambient temperature so as to explore its effect on animal health, particularly during the peri-partum period and its benefit in individuals with haemostatic challenges.
Decentralized state estimation for flexible space structures

The application of decentralization for the estimation of the state of a large-scale system is detailed. Decentralized estimation requires the global system be decomposed into a set of local models. The local models can have an order less than the global model if uncoupled and weakly coupled dynamics are neglected. Each local model computes a local state estimate, which can be combined to form the global state estimate. A simple system is studied to determine the types of coupling, and to determine the sensitivity of the state estimator to the coupling terms. A technique is presented, based on model reduction theoty, which provides a procedure for generating the local models from a heavily coupled global model. A detailed example is presented with the design of a decentralized state estimator for the Space Intereferometry Mission (SIM) spacecraj?
Precise Timing of Digital Signals: Circuits and Applications

With the rapid advances in process technologies, the performance of state-of-the-art integrated circuits is improving steadily. The drive for higher performance is accompanied with increased emphasis on meeting timing constraints not only at the design phase but during device operation as well. Fortunately, technology advancements allow for even more precise control of the timing of digital signals, an advantage which can be used to provide solutions that can address some of the emerging timing issues. In this thesis, circuit and architectural techniques for the precise timing of digital signals are explored. These techniques are demonstrated in applications addressing timing issues in modern digital systems. A methodology for slow-speed timing characterization of high-speed pipelined datapaths is proposed. The technique uses a clock-timing circuit to create shifted versions of a slow-speed clock. These clocks control the data flow in the pipeline in the test mode. Test results show that the design provides an average timing resolution of 52.9ps in 0. 18μm CMOS technology. Results also demonstrate the ability of the technique to track the performance of high-speed pipelines at a reduced clock frequency and to test the clock-timing circuit itself. In order to achieve higher resolutions than that of an inverter/buffer stage, a differential (vernier) delay line is commonly used. To allow for the design of differential delay lines with programmable delays, a digitally-controlled delay-element is proposed. The delay element is monotonic and achieves a high degree of transfer characteristics’ (digital code vs. delay) linearity. Using the proposed delay element, a sub-1ps resolution is demonstrated experimentally in 0. 18μm CMOS. The proposed delay element with a fixed delay step of 2ps is used to design a high-precision all-digital phase aligner. High-precision phase alignment has many applications in modern digital systems such as high-speed memory controllers, clock-deskew buffers, and delay and phaselocked loops. The design is based on a differential delay line and a variation tolerant phase
Health Care Supervision for Children With Williams Syndrome

This set of recommendations is designed to assist the pediatrician in caring for children with Williams syndrome (WS) who were diagnosed by using clinical features and with chromosome 7 microdeletion confirmed by fluorescence in situ hybridization, chromosome microarray, or multiplex ligation-dependent probe amplification. The recommendations in this report reflect review of the current literature, including previously peer-reviewed and published management suggestions for WS, as well as the consensus of physicians and psychologists with expertise in the care of individuals with WS. These general recommendations for the syndrome do not replace individualized medical assessment and treatment.
Application of Back-Propagation Network in Healthcare Industry

Distance Home Care will become a trend in the twenty-first century. This study employed a new method (nonlinear method-Back-Propagation Network (BPN) method of Artificial Neural Networks (ANN)) to analyze the adoption model of distance home care. This study focused on citizens in Taiwan as research subjects. The main research result showed that people’s perceived usefulness (PU) must be raised in order to effectively increase the adoption of distance home care. Moreover, this research has proved that the utilization of the adoption model of distance home care established by BPN is feasible. These findings may offer significant reference for subsequent studies. In addition, using the BPN model, we don’t need to restricted in the research data whether for linear or nonlinear.
Change detection based on integration of multi-scale mixed-resolution information

In this paper, a new method of unsupervised change detection is proposed by modeling multi-scale change detector based on local mixed information and we present a method of automated threshold. A theoretical analysis is presented to demonstrate that more comprehensive information is taken into account by the integration of multi-scale information. The ROC curves show that change detector based on multi-scale mixed information(MSM) is more effective than based on mixed information(MIX). Experiments on artificial and real-world datasets indicate that the multi-scale change detection of mixed information can eliminate the pseudo-change part of the area. Therefore, the proposed algorithm MSM is an effective method for the application of change detection.
Rituximab for ANCA-associated vasculitis – not everything in the garden is rosy

Rituximab is a well-studied biologic agent in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). However, new data continue to emerge. In a large cohort of patients with AAV, Cortazar et al showed that remission induction treatment with rituximab resulted in a preferential decline in ANCA titers relative to total immunoglobulin G (IgG) levels (47-48% vs. 6% per month, respectively) [1]. Furthermore, IgG levels remained essentially stable during prolonged maintenance therapy. Serious infections were associated with hypogammaglobulinemia (<4 g/L) but the latter was a rare finding (4.6%). During maintenance therapy with a relatively high rituximab exposure (1000 mg dose every 4 months for 2 years, followed by 1000 mg every 6 months), only 5 patients (2.1%) required treatment with intravenous immunoglobulin (IVIG) for recurrent infections. A preferential decline in rheumatoid factor and antibodies to cyclic citrullinated peptide compared to total immunoglobulin levels was also shown in patients with rheumatoid arthritis [2].
Technology use and self-perceptions of English language skills among urban adolescents

Technology including social media and other technology applications enabled by different technology devices offer many possibilities for second language learners to improve their learning, if they are interested in doing so. We investigated purposes for using technology among urban adolescents, including both English language learners (ELLs) and native English speakers (NESs). Data were collected through a survey of 531 students in an urban public middle school in the USA. The results showed that students used technology for diverse purposes regardless of their first language background. Although overall technology students' access was comparable to national averages, the use of technology for many specific purposes was markedly lower, lending support to the notion of a new digital divide between students from high- and low-income families based on technology knowledge and meaningful application of such knowledge rather than mere access. Student reports of their own English skills were related to various specific uses of technology, e.g., blogging and email. These relationships were stronger for ELLs, particularly those in grade 6, than for NESs. The results suggest that younger ELL adolescents may be more aware of their language constraints and prone to use technology in certain ways than their NES peers. These findings provide some preliminary insights into the complex relationships between language skills and student preferences for technology use and can ultimately provide guidance for the integration of technology into language and literacy instruction for linguistically diverse urban adolescents.
A High-Performance, Low-Cost Multiprocessor Bus for Workstations and Midrange Servers

The HP 9000 K-class servers and J-class workstations are the first systems to introduce a low-cost, high-performance bus structure named the Runway bus. The Runway bus is a new processor-memory-I/O interconnect that is ideally suited for one-way to four-way symmetric multiprocessing for high-end workstations and midrange servers. It is a synchronous, 64-bit, split-transaction, time multiplexed address and data bus. The HP PA 7200 processor and the Runway bus have been designed for a bus frequency of 120 MHz in a four-way multiprocessor system, enabling sustained memory bandwidths of up to 768 Mbytes per second without external interface or “glue” logic. The goals for the design of the Runway protocol were to provide a price/performance-competitive bus for one-way to four-way multiprocessing, to minimize interface complexity, and to support the PA 7200 and future processors. The Runway bus achieves these goals by maximizing bus frequency, pipelining multiple operations as much as possible, and using available bandwidth very efficiently, while keeping complexity and pin count low enough so that the bus interface can be integrated directly on the processors, memory controllers, and I/O adapters that connect to the bus. Overview The Runway bus features multiple outstanding split transactions from each bus module, predictive flow control, an efficient distributed pipelined arbitration scheme, and a snoopy coherency protocol, 1 which allows flexible coherency check
Blood or No Blood for Coronary Artery Bypass Surgery: Simple Concept but a Sublime Scientific Argument

Bleeding disorders post cardiopulmonary bypass (CPB) is a common complication of cardiac surgery. It results from impaired hemostasis and coagulation system and requires transfusion of autologous or allogeneic blood products such as platelet concentrates, fresh frozen plasma, and cryoprecipitate [1,2]. Consequently, transfusion of allogeneic blood products may expose the patient to additional risks such as transfusion reactions, viral transmissions, and immunosuppression and increased expense [1-3]. The excessive activation of the CPB modulated haemostatic system, relating to interaction of blood with nonendothelial CPB surface, activation of the extrinsic clotting pathway secondary to surgical trauma and retransfusion of pericardial blood has given rise to numerous pharmacologic and non-pharmacologic strategies as means to attenuate this alterations in the haemostatic system [4,5].
Comparison of Clone Detection Tools: CONQAT and SolidSDD

Copying and pasting the code fragment leads to the term so called code clone. This becomes a major issue in large software systems. Clones can be roughly classified into four types-type1 clones, type 2 clones, type3 clones, and type 4 clones. In this paper we are going to compare two clone detection tools i.e. CONQAT and solidSDD on the basis of various clone metrics. solidSDD is an application for detecting and managing duplicate code. It can be used to analyse large projects and detect code that has been cloned (e.g., via cut-n-paste operations) during development. Identifying such code fragments can be very useful for facilitating development and maintenance, or for reducing the memory footprint of an application.
ON THE EFFICIENCY OF TIMEOUT-BASED DOS ATTACK PROTECTIONS

In this paper, we study the performance of timeout-based protection against ﬂood denial-of-service (DoS) attacks on connection-oriented protocols, where server resources are depleted by incompleted illegitimate requests generated by the attacke (e.g. SYN-ﬂooding attacks). The use of connection timeouts by most of these protocol has the side-eﬀect or providing some protection against DoS attacks, since illegitimate requests time out more often than legitimate ones. For that reason, simple threshold-based dynamic adjustments of timeout values have been proposed and implemented as a DDoS attack mitigation counter-measure: when the number of connections go above a certain threshold, decrease the timeout value. Here, we introduce a Markov chain model in order to analyse the tradeoﬀ between attacker and defender resource consumptions for various connection management strategies, whilst maintaining a similar quality of service. We use this model and experimental simulations to compare the performance of the simpler threshold-based strategies with a slightly more sophisiticated, yet simple and eﬃcient, linear timeout adjustment strategy. Both modeling and simulations indicate that threshold-based protection performs better than the standard ﬁxed-timeout strategy, and that linear timeout adjustment performs better than both. We further consider the performance of two alternative methods of implementing adjustable timeout strategies: the deterministic method, where connections are ﬂushed when a pre-determined expiry time (based on the timeout value at arrival) is reached, and the defered method, where elapsed time is continuously compared with the current timeout value. Simulations indicate that the latter has superior performance in all cases.
High Resolution Esophageal Pressure Topography (HREPT) in Asymptomatic Volunteers. A Comparative Study Between Solid-state and Water-perfused Systems

Background and Aim: a) HREPT is the most accurate technique for identifying esophageal motility disorders (EMD). Results: Twenty HV were included, 14 women, mean age 34 (24-55) years. The pressures in the UES and LES pressures, IRP are lower with the perfusion system (p 0.0064, 0.008 and 0.0061, respectively) and have a faster peristalsis registration with the solid system, (DL p 0.0002). With the CC 2012, the solid state system presented a higher frequency of volunteers with hypotensive peristalsis (p 0.0143).
Text Summarization Techniques Applied to Source Code Summary Generation and Evaluation

This dissertation explores the use of text summarization technology for generating automatic descriptions of source code artifacts. Firstly, the thesis reports the results of empirical studies aimed at investigating how developers summarize code artifacts when understanding them. These results are useful in explaining how developers abstract source code, in gaining insights about the comprehension process, in explaining the role of code elements in such a process, and for the development of automatic source code summarization tools. Secondly, the dissertation describes several approaches for creating short and accurate textual descriptions for various types of code entities. The results of the evaluations indicate that text summarization techniques are suitable for automatic source code summarization since developers generally agree with the summaries produced by the proposed methods. Thus, these summaries can be useful for improving software comprehension processes, which usually occur during software maintenance tasks.
Stroma liquid biopsy™-a proteomic model of the systemic response to cancer

The advancements in “nextgen” and rapid genome sequencing have spawned new companies for liquid biopsy products and services that are quick, minimally invasive and that allow clinicians to monitor the course of therapy and to forecast recurrent disease. While these are certainly exciting prospects, challenges remain as genomic instability is a fundamental hallmark of cancer cells [1]. So in many respects, genomic driven approaches will always suffer the problem of shooting after a moving target.
Securing Software Architectures for Trusted Processor Environments

Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto. fi Author Jan-Erik Ekberg Name of the doctoral dissertation Securing Software Architectures for Trusted Processor Environments Publisher School of Science Unit Computer Science and Engineering Series Aalto University publication series DOCTORAL DISSERTATIONS 75/2013 Field of research Platform Security Manuscript submitted 23 January 2013 Date of the defence 24 May 2013 Permission to publish granted (date) 12 March 2013 Language English Monograph Article dissertation (summary + original articles)
Avaliação nutricional da população adulta de Esmeraldas (Equador)

Objective To analyse the nutritional status of the adult population in Esmeraldas by means of anthropometric measurements, the input of macro and micronutrients in the diet, and the adequacy estimation of nutrient intake by hispanic Dietary Reference Instakes along with the sex and the age influence. Methods Nutrient intake data were obtained by personal interview with the application of two 24 hour recalls (weekend and weekday). The anthropometric indicators analysed were body mass index, waist circumference and blood pressure. Nutriplato version 2.0 software was used for the two 24-hours food recall surveys data processing, and for the respective calculations of macronutrients, micronutrients and Dietary Reference Intakes. Means and standard deviations were calculated for anthropometry, nutrient intakes and Dietary Reference Instakes. The General Linear Model was applied to identify differences in relation to nutrient intakes considering sex, profession, body mass index, group, origin and day of the week as factors. Results Statistical analysis showed significant differences mainly in carbohydrates, fiber, calcium, phosphorus, iron, sodium, iodine, and vitamin E. Dietary intakes were compared with the Federación Española de Sociedades de Nutrición, Alimentación y Dietética Dietary Reference Intakes requirements and calcium, potassium, iodine, riboflavin, pantothenic acid, biotin, vitamin D, vitamin E, fiber, monounsaturated fatty acids and polyunsaturated fatty acids are below the Dietary Reference Instakes in all ages and gender subgroups. The anthropometric results obtained indicated that 67.0% of the population were overweight and obese, the 87.7% of the adults suffered from prehypertension and the waist circumference indicated that 73.0% of the subjects were established in the range of high risk of cardiovascular disease.
Correlation between Hyperlipidemia and Hypertension, Mean Arterial Pressure, Pulse Pressure among Africans

The diagnosis of familial hypercholesterolemia by genetic testing is hampered by its cost and effectiveness [1] in many parts of the world including Africa. Familial Hypercholesterolemia (FH) is a common cause of premature cardiovascular disease and is often undiagnosed in young people [2]. The principal metabolic causes of atherosclerosis include hyperlipidemia, hypertension, obesity, insulin resistance and diabetes mellitus. Volume 5 Issue 6 2017