Miracle-dz/UniFAR-FTUs huggingface dataset:
Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins

Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation of cellular process and have been identified as positive mediators of apoptosis via extrinsic and intrinsic death-regulating signaling pathways. Tumor suppressor activities have been shown for DAPk1 and DAPk2 and they are downregulated in e.g., Hodgkin’s (HL) and B cell lymphoma (CLL), respectively. Here, we review a targeted therapeutic approach which involves reconstitution of DAPks by the generation of immunokinase fusion proteins. These recombinant proteins consist of a disease-specific ligand fused to a modified version of DAPk1 or DAPk2. HL was targeted via CD30 and B-CLL via CD22 cell surface antigens.
Suppression of lytic effect of beta lactams on Escherichia coli and other bacteria.

Growth of E. coli at pH 5 protected the bacteria against the lytic effect of beta lactam antibiotics typically observed when the cells are grown at pH 7 or 7.5, i.e., the pH values routinely used in laboratory experiments. In contrast, the typical effects of beta lactam antibiotics on cellular shape and elongation and cell division appeared to be similar in cultures grown under neutral and acid pH conditions. The pH-dependent antibiotic tolerance can also be demonstrated with pneumococci, staphylococci, streptococci, and Bacillus subtilis. We suggest that the mechanism of the pH-dependent antibiotic tolerance may involve either the production of a more stable plasma membrane or the suppression of the activity of a murein hydrolase(s) that catalyzes the antibiotic-induced lysis; at least a fraction of these enzyme molecules may be localized at the cell surface and be accessible to experimental manipulation.
Irrelevant variability normalization based HMM training using VTS approximation of an explicit model of environmental distortions

In a traditional HMM compensation approach to robust speech recognition that uses Vector Taylor Series (VTS) approximation of an explicit model of environmental distortions, the set of generic HMMs are typically trained from “clean” speech only. In this paper, we present a maximum likelihood approach to training generic HMMs from both “clean” and “corrupted” speech based on the concept of irrelevant variability normalization. Evaluation results on Aurora2 connected digits database demonstrate that the proposed approach achieves signiﬁcant improvements in recognition accuracy compared to the traditional VTS-based HMM compensation approach.
Miscibility Behavior and Formation Mechanism of Stabilized Felodipine-Polyvinylpyrrolidone Amorphous Solid Dispersions

In the present study, solid dispersion systems of felodipine (FEL) with polyvinylpyrrolidone (PVP) were developed, in order to enhance solid state stability and release kinetics. The prepared systems were characterized by using Differential Scanning Calorimetry, X-Ray Diffraction, and Scanning Electron Microscopy techniques, while the interactions which take place were identified by using Fourier Transformation-Infrared Spectroscopy. Due to the formation of hydrogen bonds between the carbonyl group of PVP and the amino groups of FEL, transition of FEL from crystalline to amorphous state was achieved. The dispersion of FEL was found to be in nano-scale particle sizes and dependent on the FEL/PVP ratio. This modification leads to partial miscibility of the two components, as it was verified by DSC and optimal glass dispersion of FEL into the polymer matrix since no crystalline structure was detected with XRD. The above deformation has a significant effect on the dissolution enhancement and the release kinetics of FEL, as it causes the pattern to change from linear to logarithmic. An impressive optimization of the dissolution profile is observed corresponding to a rapid release of FEL in the system containing 10% w/w of FEL, releasing 100% in approximately 20 min. The particle size of dispersed FEL into PVP matrix could be classified as the main parameter affecting dissolution optimization. The mechanism of such enhancement consists of the lower energy required for the dissolution due to the amorphous transition and the fine dispersion, which leads to an optimal contact surface of the drug substance with the dissolution media. The prepared systems are stable during storage at 40 ± 1°C and relative humidity of 75 ± 5%. Addition of sodium docusate as surfactant does not affect the release kinetics, but only the initial burst due to its effect on the surface tension and wettability of the systems.
A process and temperature invariant on-chip resistor and its application

This paper presents a novel bias circuit for achieving process and temperature invariant resistor using a MOSFET operating in triode region. The proposed circuit comprises of an enhanced process tracking circuit and complementary to absolute temperature (CTAT) voltage generators. The proposed circuit has been designed and optimized in 180nm mixed-mode CMOS technology. Exhaustive Montecarlo simulations show that the ON resistance of the MOSFET (RON) varies only by ± 7.6% with process and ± 1.2% with temperature ranging from 0°C to 100°C. The proposed bias circuit reduces variation in RON by a factor of 3.4 as compared to a fixed bias MOSFET. The proposed circuit consumes 130μW power.
Adaptation of phonetic feature analyzers for place of articulation.

A series of experiments was conducted to determine the effects of selective adaptation on the perception of linguistic feature contrasts. The test stimulus consisted of a series of synthetic speech sounds, 13 CV syllables which varied in the starting frequency and direction of second‐ and third‐formant transitions. Variations in these formant transitions are sufficient for the perceived consonant distinctions along what linguists have termed the place of articulation dimension; in this case, the perceived distinctions were among the syllables [b ae], [d ae], and [g ae]. It was found that a significant adaptation effect could be obtained for the feature place, as measured by both identification and discrimination responses. For various adapting stimuli, alterations in perception occurred, such that test stimuli lying near a phonetic boundary, normally perceived as having the same place value as the adapting stimulus, were perceived after adaptation as having a systematically different place value. In addition.
EFFICACY OF CLINICAL HYPNOSIS IN THE ENHANCEMENT OF QUALITY OF LIFE OF TERMINALLY ILL CANCER PATIENTS

The fact that terminal cancer patients experience considerable psychological distress is now undisputed, but the effectiveness of psychological treatments in relieving this suffering is less clear. The aim of the present research was to evaluate the efficacy of clinical hypnosis in the enhancement of quality of life of patients with far-advanced cancer. Fifty terminally ill cancer patients were randomly assigned to two groups: standard care and hypnosis. Patients in the standard care group received routine medical and psychological care. Their medical treatment included pharmacological management of pain and other symptoms following the World Health Organization’s model of palliative care (WHO, 1990). The psychological support consisted of supportive counselling based on the cognitive existential therapeutic tradition. In addition to the standard care, patients in the hypnosis group received weekly sessions of hypnosis with a therapist for four weeks. Outcome measures included quality of life, as measured by The Rotterdam Symptom Checklist (DeHaes, Olschewski, Fayers, Visser, Cull, Hopwood and Sanderman, 1996), and depression and anxiety, as measured by The Hospital Anxiety and Depression Scale (Zigmond and Snaith, 1983). Results demonstrated that at the end of intervention patients in the hypnosis group had significantly better overall quality of life and lower levels of anxiety and depression when compared to the standard care group. It is concluded that hypnosis is effective in the enhancement of quality of life in terminally ill cancer patients.
Coping with age related changes in the elderly

Aging is viewed as something to be fought off for as long as possible. Regardless of how liberated we’ve become, many women and men still experience aging as a threat to their sense of self worth and quality of life. It is pretty much expected that middle age will bring a “crisis” and far too often we hear seniors lament that “I thought these were supposed to be the golden years. ” Whole industries are built on the attempt to stay young – from hair colors to face lifts to Viagra.
Appendectomy in retrograde order for complete removal of endometriosis

Endometriosis frequently involves the intestines. Appendectomy would be often required as part of complete removal of endometriosis. We present a patient with endometriosis who required very difficult appendectomy. For complete removal of endometriosis, hysterectomy, bilateral salpingooophorectomy, low anterior resection and accompanying pelvic peritonectomy were performed through a mid-line incision. Unexpectedly, the appendiceal tip was attached to peri-hepatic tissue with the appendix adhered to the surrounding peritoneum and bowel. Completion of the appendectomy was possible in retrograde order after extension of the surgical incision above the umbilicus. Our findings suggest that preoperative image evaluation for location or position of the appendix might be helpful in patients with suspected endometriosis to offer correct counselling, obtaining adequate consent, determining the optimal surgical approach and scheduling opportune intraoperative consultation by a colorectal surgeon.
Calcium solubilization and retention in the gastrointestinal tract in chicks (Gallus domesticus) as a function of gastric acid secretion inhibition and of calcium carbonate particle size

In chicks, immature pullets and laying hens, the inhibition of gastric acid secretion by omeprazole, an H+,K+-transporting ATPase (EC 3.6.1.36) inhibitor, greatly increased proventricular and gizzard pH values. Consequently, gizzard soluble Ca concentration deceased and the insoluble Ca fraction increased. Inhibition of acid secretion increased duodenal pH values in immature pullets and laying hens but not in chicks. Duodenal soluble and ionic Ca concentrations were lowered by gastric acid inhibition in chicks and to a larger extent in immature pullets and laying hens. The use of Ca of coarse particle size increased the gizzard insoluble Ca fraction in chicks and pullets. However, it did not influence its soluble Ca fraction in chicks but tended to reinforce the negative effect of omeprazole on soluble Ca in the gizzard and duodenum of chicks and laying hens. Coarse particles of Ca led to an increase in gizzard and duodenal soluble Ca at the end of eggshell calcification in laying hens. An enhancement in the level of Ca in the diet from 10 to 36 g/kg increased gizzard soluble Ca and duodenal soluble and ionic Ca concentrations in immature and adult hens. Intestinal Ca retention and bone mineralization was unaffected by gastric acid inhibition in chicks but were largely diminished by the use of coarse particles of Ca. Gastric acid inhibition was associated in laying hens with decreased Ca retention to a small extent and with reduced eggshell quality. These observations confirm that gastric acid secretion is of importance for CaCO, solubilization but question its role as a prerequisite for intestinal Ca retention in chicks and even in hens fed on a high Ca diet.
Monitoring infrastructure for Grid scientific workflows

Scientific workflows, being heterogeneous, loosely coupled, large-scale and distributed, pose new challenges on application monitoring. In this paper, we identify the main challenges for a monitoring infrastructure for grid scientific workflows. In order to address those challenges, we describe key design elements of a monitoring infrastructure facilitating interoperability between diverse monitoring and instrumentation tools. We propose a standardized taxonomy for grid workflow monitoring events. Automatic resource discovery is identified as the key problem to enable on-line monitoring of grid workflows. The solution to this problem is proposed based on a DHT infrastructure federated with monitoring services. This solution is next evaluated using a model-based performance evaluation. We also propose an ontology-based monitoring information model to describe records of workflow runs.
Effects of Adding Unsaturated Fatty Acids on Fatty Acid Composition of Saccharomyces cerevisiae and Major Volatile Compounds in Wine

The synergistic influences of three unsaturated fatty acids (UFAs, namely linoleic acid, oleic acid and linolenic acid) on the fatty acid composition of Saccharomyces cerevisiae and major volatile compounds were investigated in synthetic grape juice. The addition of UFAs led to a corresponding increase in UFAs in the cellular lipid, which was accompanied by a reverse reduction in the content of medium-chain saturated fatty acids (C6:0 to C14:0) and little variation in that of long-chain saturated fatty acids (C16:0 to C24:0). The supplementation of UFAs considerably improved yeast growth and fermentation activity and, in particular, increased the concentrations of most volatile compounds in wine, including higher alcohols (2-phenylethanol, 2-methyl-1-propanol and 3-(methylthio)-1-propanol), medium-chain fatty acids (butanoic acid, hexanoic acid and octanoic acid), acetate esters (isoamyl acetate and 2-phenylethyl acetate) and all ethyl esters. Remarkable linear relationships were further found between ethyl esters and the concentration of the added UFAs (R2 from 0.909 to 0.996), which significantly intensified the fruity, flowery and sweet attributes of the final wine, as assessed by calculating the odour activity values. Our results suggest that rationally increasing the concentration of UFAs is not only a practical method to improve yeast fermentation activity, but also a potential approach to manipulating wine aroma.
Abduction Reason And Science Processes Of Discovery And Explanation

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Presentation of a Visual Nearby Moving Object Alters Stream/Bounce Event Perception

Two identical visual objects moving across each other in a two-dimensional display can be perceived as either streaming through or bouncing off each other. The bouncing event percept is promoted by the presentation of a brief sound at the point of coincidence of the two objects. In this study, we examined the effect of the presence of a moving object near the two objects as well as the brief sound on the stream/bounce event perception. When both the nearby moving object and brief sound were presented, a streaming event, not a bouncing event, was robustly perceived (experiment 1). The percentage of the streaming percept was also systematically affected by the proximity of the nearby object (experiment 2). These results suggest that the processing of intramodal grouping between a nearby moving object and either of the two objects in the stream/bounce display interferes with crossmodal (audiovisual) processing. Moreover, we demonstrated that, depending on the trajectory of the nearby moving object, the processing of intramodal grouping can promote the bouncing percept, just as crossmodal processing does (experiment 3).
A Cooling System for an Automobile Based on Vapour Absorption Refrigeration Cycle Using Waste Heat of an Engine.

Now a days the air conditioning system of cars is mainly uses “Vapour Compression Refrigerant System” (VCRS) which absorbs and removes heat from the interior of the car that is the space to be cooled and rejects the heat to atmosphere. In vapour compression refrigerant system, the system utilizes power from engine shaft as the input power to drive the compressor of the refrigeration system, hence the engine has to produce extra work to run the compressor of the refrigerating system utilizing extra amount of fuel. This loss of power of the vehicle for refrigeration can be neglected by utilizing another refrigeration system i.e. a “Vapour Absorption Refrigerant System”. As well known thing about VAS that these machines required low grade energy for operation. Hence in such types of system, a physicochemical process replaces the mechanical process of the Vapour Compression Refrigerant System by using energy in the form of heat rather than mechanical work. This heat obtained from the exhaust of high power internal combustion engines.
Differential expression of the cytotoxic and hemolytic activities of the ApxIIA toxin from Actinobacillus pleuropneumoniae

The ApxIIA protein secreted from Actinobacillus pleuropneumoniae is both hemolytic and cytotoxic. However, when the cloned apxII operon is expressed in Escherichia coli, two forms of the ApxIIA protein can be recovered. Toxin which remains intracellular has hemolytic and cytotoxic activities, while toxin that is secreted is cytotoxic with little or no hemolytic activity. This indicates that the cytotoxicity of ApxIIA is independent of its hemolytic activity.
Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes

Canalicular bile is formed by the osmotic filtration of water in response to osmotic gradients generated by active transport at the apical and basolateral plasma membrane domains of hepatocytes. We recently demonstrated that mixed plasma membrane fractions isolated from rat hepatocyte couplets contain lipid microdomains (“rafts”) enriched in cholesterol and sphingolipids and AQP8 and 9. We isolated lipid microdomains from hepatocyte apical and basolateral plasma membrane domains using Triton X‐100 as detergent, and characterized their lipid and protein composition. A Triton‐insoluble band (“raft fraction”) at the 5%/30% sucrose interface in both apical and basolateral fractions was enriched for alkaline phosphatase (apical) and Na/K ATPase (basolateral) and was negative for amino peptidase‐N. This detergent‐insoluble band was also positive for caveolin‐1 (a “raft” associated protein) and negative for clathrin (a “raft” negative protein). Lipid analysis showed that, the Triton‐insoluble fraction was highly enriched in cholesterol and sphingolipids. Immunofluorescence staining on hepatocyte couplets for both caveolin‐1 and cholera toxin B showed a punctate distribution on both the apical and basolateral plasma membranes, consistent with localized membrane microdomains. Dot blot analysis showed that the “raft” associated ganglioside GM1 was enriched in the detergent‐insoluble fraction both domains. Furthermore, exposure of isolated hepatocytes to glucagon, a choleretic agonist, significantly increased the expression of AQP8 associated with the apical microdomain fractions but had no effect on AQP9 expression in the basolateral microdomain fractions. In conclusion, “rafts” represent target microdomains for exocytic insertion and retrieval of “flux proteins”, including AQPs, involved in canalicular bile secretion. (HEPATOLOGY 2006;43:287–296.)
Effects of enzyme replacement therapy in adult patients with Fabry disease on cardiac structure and function: a retrospective cohort study of the Fabry Münster Study (FaMüS) data

Objective Fabry disease (FD) is an X-linked inborn error of glycosphingolipid catabolism caused by deficient lysosomal α-galactosidase A activity. Progressive accumulation of globotriaosylceramide and related glycosphingolipids in vascular endothelial lysosomes of the heart, kidneys and brain is responsible for the main disease manifestations. The aim of our study was to assess short-term and long-term effects of enzyme replacement therapy (ERT) on cardiac mass and function. Design Retrospective cohort study. Setting Hospital outpatient clinic. Participants 40 FD patients (21 men, 19 women) receiving agalsidase β-ERT. Outcome measures The focus at baseline and follow-up examinations was on structural, functional (Doppler-echocardiography) as well as electrical changes (ECG) and blood pressure. Results In the Early Group, systolic and diastolic blood pressures significantly decreased. Left-ventricular (LV) also decreased; however, wall thickness and LV mass index showed no further increase. VE as an indicator for diastolic function significantly improved (64±21 vs 75±27 cm/s, p=0.038). There were no significant changes of ECG parameters. There were few relevant changes in the Late Group, albeit systolic blood pressure significantly decreased and QRS duration significantly increased. In conclusion, echocardiographic left-ventricular mass index, interventricular septum thickness, left-ventricular posterior wall, left-ventricular end-diastolic dimension) and diastolic function parameters are valuable for follow-up and guidance of therapy. Conclusions The primary positive impact of ERT appears to be an early effect after the start of therapy, and early initiation of ERT should be recommended.
Social capital and the net

Social Capital and the Net A century and a half ago, the French journalist Alexis de Tocqueville travelled throughout the U.S. marvelling at the generosity of the American people. “When an American asks for the cooperation of his fellow citizens,” Tocqueville wrote, “it is seldom refused; and I have often seen it afforded spontaneously, and with great goodwill” [8]. He attributed this generosity to Americans’ tendency to look beyond their own immediate concerns. “The principle of self-interest rightly understood produces no great acts of self-sacrifice, but it suggests daily small acts of self-denial . If the principle of interest rightly understood were to sway the whole moral world, extraordinary virtues would doubtless be more rare” [8]. This idea of self-interest (rightly understood) we now call “trust” in other people. According to Tocqueville and many others, people develop trust in each other when they join for common purposes in civic associations. Indeed, Robert Putnam, a professor at Harvard University, refers to a “virtuous circle” of trust, including group membership and informal social ties, that has become known as “social capital” [5]. Social capital helps make society and its governments run more smoothly. Beginning in the late 1960s and early 1970s, Americans began to withdraw from participation in all sorts of civic groups—from such traditional service organizations as the Rotary Clubs, Kiwanis, and League of Women Voters, to bowling leagues and card-playing clubs. Americans socialized less with friends and neighbors and voted less often in elections. The inevitable result was that Americans became less trusting of one another [6]. In 1960, 58% of Americans believed “most people can be trusted” (as opposed to saying “you can’t be too careful in dealing with people”). By the 1990s, barely more than 33% of Americans trusted one another, according to national surveys, including the General Social Survey and the American National Election Study. Americans had lost their sense of community. They didn’t mix with one another as much as they once did and didn’t trust one another as much as they once did. They became more balkanized, and their public life became more contentious, while their national institutions (especially the U.S. Congress) found it increasingly difficult to compromise on even the most basic public policy questions. The villain in the decline of social capital, Putnam argues, is technology—initially television, now the