Miracle-dz/UniFAR-FTUs huggingface dataset:
Estrogens, insulin status and interrelated lifestyle factors on females with breast carcinomas

Background: lifestyle is a significant vital part of malignancy care, as well as metabolic health disorders, which could be a high-risk factor for breast cancer. The objective of this scientific work is to study at the time of diagnosis the changes in insulin, estrogens (Estradiol E2 and Estriol E3) concentrations and some other related lifestyle aspects as a risk factor of breast cancer. Materials and Methods: A total of 160 Sudanese women were subjected for study and then divided into two groups, 80 females were breast cancer patients against 80 other healthy women of matching the age and Body Mass Index (BMI) was acted as reference subjects. Smoking, medical prescriptions, physical activity BMI and nourishment behaviour were considered and studied as an individual lifestyle factor. Results: Upon comparison between premenopausal breast carcinoma subjects versus matching healthy volunteers, the insulin levels showed no significant difference as the (p-value was 0.08). While the estradiol (E2) concentration recorded a significant elevation with (p-value=0.001) and both E2 levels were within the reference values, the estriol (E3) values registered a significant drop of a p=<0.001. Concerning the postmenopausal patient’s comparison against the controls, although the insulin levels of both groups were exceeding the normal international range, correspondingly showed no significant variations between the same studded groups as p-value=0.2. Estradiol (E2) concentration of the patients showed a significant raise up comparing to the controlees with a p-value equivalent to 0.001, while estriol (E3) levels decreased in both postmenopausal groups cases patients and controls. Conclusion: In conclusion, high E2 levels found to be related to breast CAs of both premenopausal as well as postmenopausal females, while the low level of E3 was associated with only premenopausal breast CAs women. Poor metabolic healthiness could be a strong risk factor of having breast CAs irrespective to the Body Mass Index (BMI). Nutrition, maintaining a healthy weight, and physical activity may reduce the risk of breast cancer
Первое успешное внедрение семейно-ориентированной медицинской помощи в отделении интенсивной терапии детского стационара Республики Казахстан (сообщение)

The Leiden Charter for Children in Hospital states that children in hospital shall have the right to have their parents or parent substitute with them at all times (European Association for Children in Hospital (EACH) 1988). In this report, the technology chain for the implementation of the patient's parent/guardian resident stay model (RSM) in pediatric anesthesiology, resuscitation and intensive care unit (PARICU) was presented. The aim of the report was to share the experience in improving patient safety and transparency of intensive care and introducing the active patient care through a «double control». The implementation of RSM has contributed to building a trustful interaction between parents/guardians and medical staff, developing skills for the proper care of children. The 24-hour family-centered care in PARICU was favorably evaluated by parents/guardians and, according to preliminary data, helped to stabilize the condition and improve the well-being of patients.
Chinese expert consensus-based guideline on assessment and management of asthma exacerbation.

The goal of management for bronchial asthma (referred to as asthma below) is to achieve overall control of the condition, including control of current symptoms and reduction on future risks. Asthma exacerbation as one of critical component of the future risks (1,2), may induce a variety of harms to the host, necessitate additional use of medical resources, impose serious socioeconomic burdens, and represent a significant cause of asthma-related disability and mortality (3). As such, prevention and reduction of the asthma exacerbation are of important relevance in improving the overall control of asthma (2-5).
Communication Strategies Inherent in Business Discourse by Miraa Traders of Igembe and Somali Origin

The main purpose of this paper was to analyse the communication strategies employed by miraa traders from Igembe and Somali origin, in their business discourse. The researchers were given the impetus to undertake this study because of the uniqueness exhibited in miraa traders’ discourse. The study aimed at establishing communication strategies depicted in their discourse and was guided by the Politeness Theory as advanced by Brown and Levinson (1987) and Communication Accommodation Theory by Giles (1971) to form the basis of its theoretical framework. The study was carried out at Muringene Market and in Maua Town in Kenya. It employed the social networks approach to identify participants. The purposive sampling procedure was used. Data was collected by tape-recording negotiations as miraa traders went on with their business interactions and through non-participants observation. Data analysis was largely qualitative. The study found out that miraa traders make use of several communication strategies such as inclusion, exclusion, directness, high level of informality, and volubility and taciturnity that form the basis of this study.
Deep-Sea Search and Recovery with and without an Underwater Vehicle

Deep-sea search and recovery mainly refer to the search, recovery, and salvage of high-value objects that are lost on the deep-sea bottom, including, among others, aircraft black boxes and underwater vehicles. The recovery and salvage of objects involves accurately obtaining their underwater position. Depending on whether or not the salvage object carries an acoustic beacon, two methods are available: onboard acoustic signal search and near-bottom sweep and search. Once the underwater position of a salvage object is known, it can be recovered and salvaged with a remotely operated underwater vehicle (ROV) and/or human-occupied vehicle (HOV). However, there are many difficulties (such as the requirement of a special technical maintenance and protection team, very high diving cost) with the practical application of existing deep-sea recovery systems that are based on the deep-sea operation of ROVs and HOVs. Based on the design concept and working model of TV-grab in oceanography, this paper proposes a new type of deep-sea recovery system that does not rely on any operational underwater vehicles for the proposed recovery process. The new deep-sea recovery system combines underwater optical imaging, mechanical docking/grasping, acoustic imaging and positioning, and propeller operation to provide low-cost and rapid deep-sea recovery.
Gyro-based lower limb asymmetry during a 4-km time trial on a velodrome among high level female cyclists

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Gyro-based lower limb asymmetry during a 4-km time trial on a velodrome among high level female cyclists Sebastien Cordillet, Nicolas Bideau, Mathieu Ménard, Guillaume Nicolas
Current advances in drug delivery systems for treatment of Triple negative breast cancer (TNBC)

Triple negative breast cancer is known to be the most malignant and aggressive form of breast cancer accompanied with poor prognosis in patients. It is characterized by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, making the TNBC cells unresponsive to hormonal therapy. Owing to its molecular heterogeneity and complexity, there are no currently available targeted treatments for TNBC. With only cytotoxic chemotherapy drugs as an established treatment option for TNBC, tumor-targeted delivery of drugs becomes an important parameter to prevent or attenuate chemotherapy-associated side effects and toxicity in TNBC patients. Thus efficient and tumor-targeting drug delivery systems are critically needed for effective treatment of TNBC. This concise review summarizes the most recent findings in the field of cancer-related drug delivery systems, focusing on the treatment of triple negative breast cancer and highlights the future directions and research perspectives in this area.
Development of Leishmania donovani in Phlebotomus argentipes & Ph. papatasi fed on kala-azar patients in Bihar.

: A total of 258 laboratory bred Ph. argentipes was fed on untreated parasitologically confirmed kala-azar patients. Successful development of parasites was noted in 0.54 per cent Ph. argentipes fed during the day and 5.33 per cent fed during the night. However, none of the 245 laboratory bred Ph. papatasi fed on the same patients, was found positive for successful development of L. donovani in the foregut.
Intrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy

Objective/Purpose. Evaluation of efficacy and safety of autologous adipose-derived regenerative cells (ADRCs) treatment in autoimmune refractory epilepsy. Patients. Six patients with proven or probable autoimmune refractory epilepsy (2 with Rasmussen encephalitis, 2 with antineuronal autoantibodies in serum, and 2 with possible FIRES) were included in the project with approval of the Bioethics Committee. Method Intrathecal injection of autologous ADRC acquired through liposuction followed by enzymatic isolation was performed. The procedure was repeated 3 times every 3 months with each patient. Neurological status, brain MRI, cognitive function, and antiepileptic effect were monitored during 12 months. Results Immediately after the procedure, all patients were in good condition. In some cases, transient mildly elevated body temperature, pain in regions of liposuction, and slight increasing number of seizures during 24 hours were observed. During the next months, some improvements in school, social functioning, and manual performance were observed in all patients. One patient has been seizure free up to the end of trial. In other patients, frequency of seizures was different: from reduced number to the lack of improvement (3-year follow-up). Conclusion Autologous ADRC therapy may emerge as a promising option for some patients with autoimmune refractory epilepsy. Based on our trial and other clinical data, the therapy appears to be safe and feasible. Antiepileptic efficacy proved to be various; however, some abilities improved in all children. No signs of psychomotor regression were observed during the first year following the treatment.
Effects of Equivalent-Oxide-Thickness and Fin-Width Scaling on In0.53Ga0.47As Tri-Gate Metal-Oxide-Semiconductor-Field-Effect-Transistors with Al2O3/HfO2 for Low-Power Logic Applications

We created tri-gate sub-100 nm In0.53Ga0. 47As metal-oxide-semiconductor-field-effect-transistors (MOSFETs) with a bi-layer Al2O3/HfO2 gate stack and investigated the scaling effects on equivalent-oxide-thickness (EOT) and fin-width (Wfin) at gate lengths of sub-100 nm. For Lg = 60 nm In0.53Ga0. 47As tri-gate MOSFETs, EOT and Wfin scaling were effective for improving electrostatic immunities such as subthreshold swing and drain-induced-barrier-lowering. Reliability characterization for In0.53Ga0. 47As Tri-Gate MOSFETs using constant-voltage-stress (CVS) at 300K demonstrates slightly worse VT degradation compared to planar InGaAs MOSFET with the same gate stack and EOT. This is due to the effects of both of the etched fin’s sidewall interfaces.
Acute low back pain – a cross sectional study : Fear-avoidance beliefs and associated characteristics

Conflicts of interest declared: none. Bakgrunn og hensikt: Fear-avoidance beliefs (FAB) er overdreven frykt for bevegelser som kan medføre unngåelse av bevegelser og aktiviteter, og bidra til å opprettholde ryggplagene. Hensiktene var å (i) avdekke forekomsten av fear-avoidance beliefs (FAB) hos pasienter med akutte korsryggsmerter og (ii) utforske sammenhenger mellom demografiske variabler, smerte og FAB i utvalget. Design: en tverrsnittsundersøkelse med strategisk utvalg. Materiale: 115 pasienter mellom 20 og 70 år gamle med akutte (varighet mindre enn 12 uker) korsryggsmerter rekruttert via fysioterapeuter på fysikalske institutter i Norge i perioden november 2006 til og med februar 2007. Metode: Spørreskjema for Fear-avoidance beliefs (FABQ). Skjemaet er delt i to deler med henholdsvis 5 spørsmål (FABQ-PA om fysisk aktivitet) og 11 (FABQ-W om arbeidsrelaterte forhold), med skåring fra 0-6 der 6 er verst. Skjema har ingen angitt kuttverdi, i artikkelen anvendes kuttverdier hentet fra andre forfattere. Pasientene ble også bedt om å angi demografiske variabler og smerte. Resultat: I alt 115 pasienter deltok i undersøkelsen: 85 prosent svarte på FABQ-W og 20.4 prosent av disse hadde høye skårer ved en kuttverdi på >29. Totalt 95 prosent svarte på FABQ-PA, av disse hadde 32.1 prosent høye skårer ved en kuttverdi >14. Gjennomsnittskår (SD) for FABQ-W var 18.3 (10.9) og FABQ-PA 12.3 (5.8). Pasienter med lavest utdanning skåret signifikant høyere på FABQ-W. Konklusjon: Høy smerteskår ved nåtidig smerte var signifikant assosiert med høye skår på FABQ-PA. I tillegg var det å være sykmeldt og ha lav utdanning signifikant uavhengig assosiert med høye skår på FABQ-W. Nøkkelord: Acute low back pain, fear-avoidance beliefs, cutoff score, formal education. fag
Biochemical and Histological Study on the Effects of Curcumin and/or Yellow Bean on Rats Drinking Ethanol Alcohol

The therapeutic effects of curcumin and/or dimethyl dimethoxy biphenyl dicarboxylate on rats drinking alcohol were evaluated in the present study. Albino Wister rats drinking 20% ethanol in drinking water were treated with curcumin (100 mg/kg body weight) and /or DDB (50 mg/ kg body weight) mixed in diet for 8 weeks. ALT and AST enzymes were significantly reduced in rat drinking alcohol and treated with DDB or Diferuloylmethane compared with rats drinking alcohol (p<0.05). On the other hand, in case of mixed treatment with curcumin and DDB, AST enzyme was elevated significantly compared with rat drinking alcohol(P<0.05). GGT enzyme was reduced after treatment of alcohol drinking rats with curcumin or DDB in comparing with alcohol drinking rats. MDA concentration in liver homogenate significantly reduced in rats drinking alcohol and treated with DDB compared with rats drinking alcohol (p<0.05). However, serum MDA showed a significant reduction in rats drinking alcohol and treated with curcumin compared with rats drinking alcohol (P<0.05). Histopathological studies revealed liver tissue damage after alcohol administration, however an improvement in liver tissue after treatment with curcumin and DDB. In conclusion, curcumin and DDB can influence and improve the impaired antioxidant defense mechanisms resulted from ethanol and combined treatment with curcumin and DDB has no effects.
Strategies to Stimulate the Economy of Contemporary Nepali Theatre

The contemporary Nepali theatre has stood at the crossroads at various junctures in time. Theatre institutions have frequently struggled for survival, primarily due to the inflating financial pressures and myopic strategic focus. For several of them, it has consequentially led them to complete shutdown. A gradually growing audience base hasn't been able to fully assure sustenance to the industry stakeholders. With such impending uncertainty hovering over the industry, theatre companies in Nepal are challenged to profitably sustain in the burgeoning entertainment industry. Sensing the imminent necessities, this paper introduces an interdisciplinary intervention by providing proven roadmaps for contemporary theatre players in Nepal. All of these strategies are derived and tailored from the domains of business and marketing. More specifically, the crux is fixated around the marketing mix model, devised by Neil Borden in the 1950s. Extracting pivotal arguments and findings from a variety of researches and studies conducted all around the world, the paper in hand attempts to synchronize conceptual underpinnings of the theories with pragmatic contexts of modern-day Nepali theatre. And before providing potential solutions, the author has also peeked into the existing economic landscape of contemporary Nepali theatre in order to identify the business related bottlenecks of the industry.
Socio-demographic Factors Affecting Initiation and Duration of Breastfeeding in a Culturally Diverse Area of North Eastern Greece.

BACKGROUND Breastfeeding is not only important for the bond between the mother and the child but is also associated with many health benefits. Socio-demographic factors have been found to be important for the initiation and longer duration of breastfeeding. AIM To record the breastfeeding characteristics and to explore possible associations with socio-cultural and demographic factors in a culturally diverse area in Greece. MATERIALS AND METHODS A questionnaire including information about breastfeeding characteristics, medical history and demographics was completed by parents of children in the primary schools of the area. RESULTS The study included 700 school-age children (352 boys), mean age 9.4±1.9 years. Breastfeeding was reported in 54.9% of them, with median (IQR) duration of 120 (range 60-360) days. Prevalence of breastfeeding was slightly higher in semi-urban areas, versus rural or urban settlements, but the duration there was significantly lower (. CONCLUSION Prevalence of breastfeeding in Greece is approximately 55%, similar to previous reports and along with duration is determined by certain socio-cultural factors.
The gastrointestinal and hepatic manifestations of the acquired immunodeficiency syndrome.

Eighty-five patients with the acquired immunodeficiency syndrome (AIDS) were treated at Fairfield Infectious Diseases Hospital between April 1984 and June 1987. Sixty per cent of patients suffered gastrointestinal symptoms during the period of study, and in a further 15% of patients, abnormalities of the gastrointestinal tract were found incidentally. The principal manifestations were oropharyngeal ulceration, dysphagia/odynophagia, abdominal pain, diarrhoea, gastrointestinal bleeding, and perianal lesions. Opportunistic diseases involving all parts of the gastrointestinal system were encountered, the most prevalent being infections that were caused by Candida spp. , cytomegalovirus, Mycobacterium avium-intracellulare and herpes simplex, and Kaposi's sarcoma. Abnormal liver-function test-results were found in 41 patients; most commonly, these were attributable to minor drug reactions, and cytomegalovirus or Myco. avium-intracellulare infection. Only one patient became jaundiced clinically. We conclude that involvement of the gastrointestinal tract is common in patients with AIDS, and that gastrointestinal lesions are an important cause of morbidity and mortality in these patients.
A Perceptual Taxonomy of Contextual Cues for Cyber Trust

People are the weakest link in the security of any computer system or network. Adversaries tactically exploit decision-making processes of computer users by preying on their propensity to trust electronic communications based on learned contextual cues and environmental influences. Despite this understanding, explorations into the psychological, experiential, technological, and environmental factors influencing the cognitive phenomena of trust and suspicion are not typically based on the cues available to computer users. This work defines a taxonomy of human-perceptible trust cues that are used to make decisions online across the domains of Web, E-mail, and Social Networking. We believe this taxonomy could be foundational for future studies of phishing attacks. The Taxonomy also has significant implications for training both cyber security personnel and general computer users, because it codifies the domain or body of knowledge that may become the basis for future development of information systems security education and training.
Realistic Virtual Actors for Training in Counterterrorism

Terrorism has become a common international threat, and is particularly problematic to counter because it occurs in a civilian rather than military context. It is difficult to differentiate terrorists from normal civilians because their strategy is to merge into the crowd and thereby avoid detection. Providing security personnel with the necessary experience to spot terrorists in a crowd can be time consuming and resource intensive. Simulation can provide a valuable complement to current approaches, making them more efficient, cost effective and reducing the manpower and infrastructure required to support training. This paper describes how realistic virtual actors can be used to provide the counterterrorism trainee with experience in detecting abnormal behaviour and using tactics that increase the visibility of a terrorist concealed in a crowd. Our approach is to use the cognitive architecture, CoJACKTM, to create virtual actors (civilians, terrorists) that react variably but realistically to the trainee’s and other virtual actors’ actions. These virtual actors are imbued with emotions, such as fear, anger and anxiety, which lead them to react plausibly to events in the scenario. The key point is that these reactions are not scripted but emerge from the interplay between the virtual actor’s cognitive and emotional faculties. This yields a flexible training environment that is responsive to what the trainee does. In many ways, it is more difficult to generate realistic behaviour in a civilian rather than military context the actions and reactions can be quite subtle. This paper outlines a civilian counterterrorism scenario, set in London, in which there is a terrorist on reconnaissance, diverse types of civilian with varying goals and emotional states. The virtual environment, VBS2TM was used to represent the physical environment and the characters’ embodiments.
Robotically Fabricated Ice Formwork: An Exploration on Casting Morphologically Programmed Complex Concrete Elements with Robotically Milled Ice Formworks

This document focuses on the exploration of casting complex concrete architectural elements with ice formwork. Replacing conventional concrete formwork with ice formwork,allows to produce architectural elements with complex geometries in a highly controlled off-site production process,with almost complete use of the mold material. Usingdigitallydrivenfabricationtoolssuchasaroboticarmmilling,the goal is to achieve 3d shapes made from one or more ice molds, able to be stacked, assembled and merged together in order to deﬁne architectural partitions. One of the main instigators of this research is the sustainability, showcased both through the usage of ice as a mold material that is 100% reusable, and the unique ability of the described process to produce topology optimized shapes in concrete, which reduces the use of this high carbon footprint material to to bare minimum. Ice formwork allows furthermore,to create bespoke shapes for every single element in an efﬁcient way. This opens new avenues for architectural design and construction. This project uses a design based research methodology, where each physical iteration is carefully evaluated against the digital model, embracing morphological material programming.