Miracle-dz/UniFAR-FTUs huggingface dataset:
Current Perspectives in the Precolonial Archaeology of Puerto Rico

During the past two decades, many of the traditional conceptions about the configuration of the cultural landscape of precolonial Puerto Rico have been critically addressed from both political and disciplinary perspectives. Colonialist undercurrents embedded in the traditional models used to structure the indigenous history of the island have come into question and some of the fundamental ideas about the social and cultural makeup of the human collectivities that inhabited Puerto Rico have been drastically altered. The timing of the initial occupation of the island has been pushed back to more than five thousand years ago and the potential origin of some of these societies has also been reconsidered, including the possibility that some of groups moved across the Caribbean Sea from the Isthmo-Colombian region from where they brought phytocultural traditions that included the cultivation of a wide array of important economic plants. The cultural landscape of the island later expanded with the arrival of migrants from the surrounding continents who participated in long-distance interaction networks, as demonstrated by the trade of exotic goods mainly used for making personal adornments. The cultural plurality that existed on the island led to the development of distinct traditions that were not only forged by the diverse interactions that took place within Puerto Rico, but also by engagements that continued to take place with the inhabitants of other islands of the Antilles and surrounding continental regions. This all led to the articulation of a mosaic of cultural traditions that were diffusely united through the intersocietal negotiation of a set of codes that allowed the different collectivities to engage with one another while retaining their differences.
Transplantability of Induced Granulosa Cell Tumors and of Luteoma in Mice. Secondary Effects of These Growths.∗

Summary Eleven ovarian tumors, induced by X-rays have been transmitted in successive passages. Eight were of the granulosa cell types, 2 were luteomas and one was a tubular adenoma. Histological changes indicate that cells of Strain III secrete estrogens. Mice bearing tumors of this strain also have a cavernous dilatation of the sinusoids of liver, spleen and adrenals. In mice bearing large luteoma of Strain IX there is profound atrophy of the adrenal cortex.
Approaching the biology of human parental attachment : Brain imaging , oxytocin and coordinated assessments of mothers and fathers

behaviors required for sensitive parenting enables the formation of each individual's first social bonds and critically shapes development. This review concentrates on magnetic resonance imaging experiments which directly examine the brain systems involved in parental responses to infant cues. First, we introduce themes in the literature on parental brain circuits studied to date. Next, we present a thorough chronological review of state-ofthe-art fMRI studies that probe the parental brain with a range of baby audio and visual stimuli. We also highlight the putative role of oxytocin and effects of psychopathology, as well as the most recent work on the paternal brain. Taken together, a new model emerges in which we propose that cortico-limbic networks interact to support parental brain responses to infants. These include circuitry for arousal/salience/motivation/ reward, reflexive/instrumental caring, emotion response/regulation and integrative/complex cognitive processing. Maternal sensitivity and the quality of caregiving behavior are likely determined by the responsiveness of these circuits during early parent-infant experiences. The function of these circuits is modifiable by current and early-life experiences, hormonal and other factors. Severe deviation from the range of normal function in these systems is particularly associated with (maternal) mental illnesses – commonly, depression and 7 erved. ea; BNST, bed nucleus of the stria terminalis; dlPFC, dorsolateral prefrontal cortex; osttraumatic stress disorder; nACC, nucleus accumbens; ACC, anterior cingulate; accumbens; OFC, orbitofrontal cortex ng, 4250 Plymouth Road, Ann Arbor, MI 48109-2700, USA. u (J.E. Swain). l. , Approaching the biology of human parental attachment: Brain imaging, oxytocin s and fathers. Brain Research (2014), http://dx.doi. org/10.1016/j.brainres. 2014.03. 007 b r a i n r e s e a r c h ] ( ] ] ] ] ) ] ] ] – ] ] ] 2 Please cite this article as: Swain, J.E. , et a and coordinated assessments of mother anxiety, but also schizophrenia and bipolar disorder. Finally, we discuss the limits and extent to which brain imaging may broaden our understanding of the parental brain given our current model. Developments in the understanding of the parental brain may have profound implications for long-term outcomes in families across risk, resilience and possible
Regulation of cotton (Gossypium hirsutum) drought responses by mitogen-activated protein (MAP) kinase cascade-mediated phosphorylation of GhWRKY59.

Drought is a key limiting factor for cotton (Gossypium spp.) production, as more than half of the global cotton supply is grown in regions with high water shortage. However, the underlying mechanism of the response of cotton to drought stress remains elusive. By combining genome-wide transcriptome profiling and a loss-of-function screen using virus-induced gene silencing, we identified Gossypium hirsutum GhWRKY59 as an important transcription factor that regulates the drought stress response in cotton. Biochemical and genetic analyses revealed a drought stress-activated mitogen-activated protein (MAP) kinase cascade consisting of GhMAP3K15-Mitogen-activated Protein Kinase Kinase 4 (GhMKK4)-Mitogen-activated Protein Kinase 6 (GhMPK6) that directly phosphorylates GhWRKY59 at residue serine 221. Interestingly, GhWRKY59 is required for dehydration-induced expression of GhMAPK3K15, constituting a positive feedback loop of GhWRKY59-regulated MAP kinase activation in response to drought stress. Moreover, GhWRKY59 directly binds to the W-boxes of DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2 (GhDREB2), which encodes a dehydration-inducible transcription factor regulating the plant hormone abscisic acid (ABA)-independent drought response. Our study identified a complete MAP kinase cascade that phosphorylates and activates a key WRKY transcription factor, and elucidated a regulatory module, consisting of GhMAP3K15-GhMKK4-GhMPK6-GhWRKY59-GhDREB2, that is involved in controlling the cotton drought response.
Vision and Challenges for Realising the Internet of Things

In the emerging Internet of Things, it is easy and cheap to make information available about virtually all physical objects as this information can be automatically created, distributed, and processed with the help of automatic identification systems. Thus, virtual counterparts of physical objects are being created, which provides links to services around these objects. Together with specialized technologies for the detection of physical tampering, software-supported systems for product authentication become universally available. This is a critical component to protect consumers, distribution channels, and markets against counterfeit products. We demonstrate how a prototypical system for product authentication can be integrated to existing business processes and be applied in various fields.
Acute infections as a means of cancer prevention: opposing effects to chronic infections?

PURPOSE Epidemiological studies have found an inverse association between acute infections and cancer development. In this paper, we review the evidence examining this potentially antagonistic relationship. METHODS In addition to a review of the historical literature, we examined the recent epidemiological evidence on the relationship between acute infections and subsequent cancer development in adult life. We also discuss the impact of chronic infections on tumor development and the influence of the immune system in this process. RESULTS Exposures to febrile infectious childhood diseases were associated with subsequently reduced risks for melanoma, ovary, and multiple cancers combined, significant in the latter two groups. Epidemiological studies on common acute infections in adults and subsequent cancer development found these infections to be associated with reduced risks for meningioma, glioma, melanoma and multiple cancers combined, significantly for the latter three groups. Overall, risk reduction increased with the frequency of infections, with febrile infections affording the greatest protection. In contrast to acute infections, chronic infections can be viewed as resulting from a failed immune response and an increasing number have been associated with an elevated cancer risk. CONCLUSION Infections may play a paradoxical role in cancer development with chronic infections often being tumorigenic and acute infections being antagonistic to cancer.
Dependence of Transverse Domain Wall Dynamics on Permalloy Nanowire Dimensions

Micromagnetic modeling was used to investigate transverse domain wall propagation through Permalloy nanowires of width, <i>w</i>, between 10 and 120 nm and thickness, <i>T</i>, between 2 and 20 nm. The transverse wall mobility below Walker breakdown, ¿, and Walker breakdown field, <i>H</i> <sub>w</sub>, depended on the exact wire dimensions, rather than simply a function of w/<i>T</i>, as suggested by 1-D analytical modeling. Empirical equations describing the <i>w</i> and <i>T</i> dependence of ¿ and <i>H</i> <sub>w</sub> were found from the micromagnetic data. As the model makes no assumptions about magnetization uniformity, these equations provide a generic description of ¿ and <i>H</i> <sub>w</sub> for transverse domain walls in Ni<sub>80</sub>Fe<sub>20</sub> nanowires.
The androgen receptor gene mutations database: 2012 update

The current version of the androgen receptor gene (AR) mutations database is described. A major change to the database is that the nomenclature and numbering scheme now conforms to all Human Genome Variation Society norms. The total number of reported mutations has risen from 605 to 1,029 since 2004. The database now contains a number of mutations that are associated with prostate cancer (CaP) treatment regimens, while the number of AR mutations found in CaP tissues has more than doubled from 76 to 159. In addition, in a number of androgen insensitivity syndrome (AIS) and CaP cases, multiple mutations have been found within the same tissue samples. For the first time, we report on a disconnect within the AIS phenotype–genotype relationship among our own patient database, in that over 40% of our patients with a classic complete AIS or partial AIS phenotypes did not appear to have a mutation in their AR gene. The implications of this phenomenon on future locus‐specific mutation database (LSDB) development are discussed, together with the concept that mutations can be associated with both loss‐ and gain‐of‐function, and the effect of multiple AR mutations within individuals. The database is available on the internet (http://androgendb.mcgill.ca), and a web‐based LSDB with the variants using the Leiden Open Variation Database platform is available at http://www.lovd. nl/AR. Hum Mutat 33:887–894, 2012. © 2012 Wiley Periodicals, Inc.
A method to model pigtails of shielded cables when using the combined MoM/MTL approach

Using systematically high-voltage shielded cables for electric powertrain requires to develop and deploy numerical simulation models to analyze the EMC issues. This paper presents a method to model pigtails of shielded cables when using the combined MoM/MTL approach to overcome the limitations of the transmission line theory. As the MoM and MTL methods are both based on different models, there cannot be any numerical connection simultaneously between each other. To study the direct coupling through different numerical models, the proposed model is based on a reformulation of the currents and the voltages at the terminations of the shielded cable described by an S-parameters black box. To confirm our approach, a comparison between the standard MTL model and a MoM full-wave model with the proposed method is done in the 10 kHz-300 MHz frequency band. The results of different numerical techniques are presented and are in good agreement.
The IL-12 Signature: NK Cell Terminal CD56+high Stage and Effector Functions 1

We report that human peripheral NK cells expressing high CD56 levels (CD56+high) are terminally differentiated cells indistinguishable from mature NK cells recently activated in the presence of IL-12, and not a functionally distinct NK-cell subset or progenitors to mature CD56+low NK cells. CD56+high NK cells coexpress all differentiation Ags constitutive or inducible in mature (CD56+) NK cells, except CD16, present at lower level than on most mature NK cells. Also, activation markers, activating receptors and adhesion molecules, and most inducible receptors are expressed exclusively and constitutively and are inducible at higher levels on CD56+high than on CD56+low NK cells. Consistent with their activated phenotype, many CD56+high NK cells are cycling and mediate heightened effector functions (proliferation, IFN-γ and IL-10 but not IL-13 production) in response to IL-12 and other NK cell-specific stimuli. Conversely, IL-12 induces on CD56+low NK cells all markers constitutively expressed on the CD56+high NK cells, concomitantly preventing the IL-2 (and IL-15)-inducible expression of NKp44 and CD16 re-expression after immune complex-induced down-modulation, and CD56−/+low NK cells acquire a CD56+high NK cell phenotype in short term in vitro culture with IL-12. The significance of these findings to the NK cell-mediated regulation of immune responses and NK cell development is discussed.
Cooperative Downlink Listening for Low-Power Long-Range Wide-Area Network

Recently, the development of the Internet of Things (IoT) applications has become more active with the emergence of low-power wide-area network (LPWAN), which has the advantages of low-power and long communication distance. Among the various LPWAN technologies, long-range wide-area network (LoRaWAN, or LoRa) is considered as the most mature technology. However, since LoRa performs uplink-oriented communication to increase energy efficiency, there is a restriction on the downlink function from the network server to the end devices. In this paper, we propose cooperative downlink listening to solve the fundamental problem of LoRa. In particular, the proposed scheme can be extended to various communication models such as groupcasting and geocasting by combining with the data-centric model. Experiments also show that the proposed technology not only significantly reduces network traffic compared to the LoRa standard, but also guarantees maximum energy efficiency of the LoRa.
The role of clinicopathologic and molecular prognostic factors in the post-mastectomy radiotherapy (PMRT): a retrospective analysis of 912 patients.

OBJECTIVE To assess the association of clinicopathologic and molecular features with loco-regional recurrence (LRR) in post-mastectomy breast cancer patients with or without adjuvant radiotherapy (PMRT). PATIENTS AND METHODS We retrospectively reviewed data of patients undergone to mastectomy followed or not by PMRT between January 2004 and June 2013. The patients were divided according to clinicopathologic and molecular sub-classification features. LRR and Cancer Specific Survival (CSS) were calculated using the Kaplan-Meier method; the prognostic factors were compared using long-rank tests and Cox regression model. RESULTS A total of 912 patients underwent to mastectomy of whom 269 (29.5%) followed by PMRT and 643 (70.5%) not; among the PMRT group, 77 underwent to the chest wall (CW) and 202 to the chest wall and lymphatic drainage (CWLD) irradiation. The median follow-up was 54 months (range, 3-118). No significant difference in terms of LRR and CSS was found between non-PMRT and PMRT group (p=0.175; and p=0.628). The multivariate analysis of LRR for patients who did not undergo PMRT showed a significant correlation with the presence of extracapsular extension (ECE) (p=0.049), Ki-67>30% (p=0.048) and triple negative status (p=0.001). In the PMRT group, triple negative status resulted as the only variable significantly correlated to LRR (p=0.006) at the multivariate analysis and T-stage also showed a trend to significance (p=0.073). Finally, no difference in LRR control was shown between CW and CWLD-PMRT (p=0.078). CONCLUSIONS After mastectomy ECE, a cut off of Ki-67>30% and triple negative status were strictly correlated with LRR regardless of clinicopathologic stage. PMRT has a positive impact in decreasing LRR in patients with this molecular profile. Besides, CW might represent a valid option for patients with one to three positive nodes.
Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2.

More than half of all chronic cancer pain arises from metastases to bone, and bone cancer pain is one of the most difficult of all persistent pain states to fully control. Several tumor types including sarcomas and breast, prostate, and lung carcinomas grow in or preferentially metastasize to the skeleton where they proliferate, and induce significant bone remodeling, bone destruction, and cancer pain. Many of these tumors express the isoenzyme cycloxygenase-2 (COX-2), which is involved in the synthesis of prostaglandins. To begin to define the role COX-2 plays in driving bone cancer pain, we used an in vivo model where murine osteolytic 2472 sarcoma cells were injected and confined to the intramedullary space of the femur in male C3HHeJ mice. After tumor implantation, mice develop ongoing and movement-evoked bone cancer pain-related behaviors, extensive tumor-induced bone resorption, infiltration of the marrow space by tumor cells, and stereotypic neurochemical alterations in the spinal cord reflective of a persistent pain state. Thus, after injection of tumor cells, bone destruction is first evident at day 6, and pain-related behaviors are maximal at day 14. A selective COX-2 inhibitor was administered either acutely [NS398; 100 mg/kg, i.p.] on day 14 or chronically in chow [MF. tricyclic; 0.015%, p.o. ] from day 6 to day 14 after tumor implantation. Acute administration of a selective COX-2 inhibitor attenuated both ongoing and movement-evoked bone cancer pain, whereas chronic inhibition of COX-2 significantly reduced ongoing and movement-evoked pain behaviors, and reduced tumor burden, osteoclastogenesis, and bone destruction by >50%. The present results suggest that chronic administration of a COX-2 inhibitor blocks prostaglandin synthesis at multiple sites, and may have significant clinical utility in the management of bone cancer and bone cancer pain.
Fairly efficient or efficiently fair: success factors and constraints of payment and reward schemes for environmental services in Asia

Payment for environmental service (PES) is strictly defined as a market-based environmental policy instrument to achieve environmental protection in the most efficient way. However, an increasing body of literature shows that the prescriptive conceptualization of PES cannot be easily generalized and implemented in practice and the commodification of ecosystem services is problematic. To investigate the underlying causes, this PhD study combines a quantitative and qualitative research approach using case studies in Indonesia, the Philippines and Nepal. The empirical observations on emerging PES-mechanisms in the Asian case studies show that interdependency of fairness and efficiency should be the main consideration in designing and implementing a PES scheme in developing countries. Neither fairness nor efficiency alone should be the primary aim but an intermediate PES that is “fairly efficient and efficiently fair” may bridge the gap between PES theory and the practical implementation of PES to increase ES provision and improve livelihoods.
Transradial access for renal artery intervention.

INTRODUCTION Percutaneous interventional procedures in the renal arteries are usually performed using a femoral or brachial vascular access. The transradial approach is becoming more popular for peripheral interventions, but limited data exists for renal artery angioplasty and stenting. METHODS We have analyzed the clinical, angiographic and technical results of renal artery stenting performed from radial artery access between 2012 and 2013. The radial artery anatomy was identified with aortography using 100 cm pig tail catheter. After engagement of the renal artery ostium with a 6F Multipurpose or 6F JR5 guiding catheter, the stenosis was passed with a 0.014" guidewire followed by angioplasty and stent implantation. RESULTS In 27 patients (mean age: 65.4 ± 9.17) with hemodynamically relevant renal artery stenosis (mean diameter stenosis: 77.7 ± 10.6%; right, n = 7; left, n = 20), interventional treatment with angioplasty and stenting was performed using a left (n = 3) or right (n = 24) radial artery access. Direct stenting was successfully performed in 13 (48%) cases, and predilatations were required in ten cases 10 (37%). Primary technical success (residual stenosis <30%) could be achieved in all cases. The mean contrast consumption was 119 ± 65 ml and the mean procedure time was 30 ± 8.2 min. There were no major periprocedural vascular complications and in one patient transient creatinine level elevation was observed (3.7%). In one patient asymptomatic radial artery occlusion was detected (3.7%). CONCLUSION Transradial renal artery angioplasty and stenting is technically feasible and safe procedure.
Trust, Social Influence, Self‐Efficacy, Perceived Risk and Internet Banking Acceptance: An Extension of Technology Acceptance Model in Indian Context

Understanding the main factors of Internet banking adoption is important for both banks and users. This paper presents an extended technology adoption model (TAM) with special reference to trust, risk, self‐efficacy and social influence, aiming to examine the factors affecting Indian consumers intentions to adopt Internet banking services. A measuring instrument is developed from existing literature and is employed personally to gather data from post-graduate students of Pondicherry University. The survey resulted in useful responses which are further analysed by employing exploratory factor analysis and multiple regression. The results indicated that perceived usefulness, perceive ease of use, perceived enjoyment, perceived image, social influence and trust in Internet banking have significant positive effect on behavioural intention. Further, it is found that perceived risk exerts significant negative effect on consumers' intention to use Internet banking.
Monitoring and Evaluation of Time Delay

In general, users act as if their behavior is controlled by a self-regulatory system (Carver & Scheier, 1998) during user-system interaction. The self-regulatory system is specified as a feedback control mechanism consisting of monitoring, evaluation, and action adjustment mechanisms. This article investigates whether perception processes take care of monitoring, and if a user's evaluation is based on the interpretation of the results of such monitoring. To do this, a typical system property, time delay, was manipulated. In an experiment, the relation between estimated task duration and actual time-to-task completion was studied. The findings support the premise that perception processes, interpreted as a monitoring mechanism, can keep track of physical task time. A monotonic, positive relation was found between the time-to-task completion and user satisfaction, which supports the assumption that objective efficiency influences the evaluation of interaction. A linear relation between the estimated duration and user satisfaction indicates that the monitoring mechanism transforms physical signals into a format that can be used in the evaluation process, thereby changing the internal reference frame of the evaluation mechanism.