Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on nucleolar organizer regions of hippocampal neuron in Alzheimer's disease.

OBJECTIVE To understand the cellular genetic expression of the cell's population by studying the nucleolar organizer regions (NORs) of hippocampal neuron of Alzheimer's disease (AD). METHODS The postmortem human hippocampal tissues were divided into three groups, namely, the young, the elderly and the AD groups. Each group contained tissues from 10 patients. The study was conducted using image pattern analysis of the nucleoli-nucleoplasms ratio of the neurons of Nissl's stained pathological cerebral hippocampal tissues, the area of stain, and the integrating absorption of nucleoli of silver-stained NORs. RESULTS The nucleoli-nucleoplasms ratio of the neurons of Nissl's stained cerebral hippocampal tissues, the area of stain, and the integrating absorption of the nucleoli of hippocampal neuron were decreased in the elderly and the AD groups as compared with the young group. However, the area of stain and the integrating absorption of the nucleoli of the hippocampal neurons were relatively increased in the AD group in comparison with the elderly group. CONCLUSION Nissl's stain demonstrates the hypofunction of the hippocampal neurons in the elderly and the AD patients. The Silver stain of NORs shows the decline of rDNA transcription activity of the nucleoli of the hippocampal neurons in the elderly and the AD patients. However, the transcription activity of the nucleoli of the hippocampal neurons of AD patients was relatively improved, and the cellular genetic expression of the cell's population was relatively strengthened. These cellular morphological changes have probably reflected the cellular defensive system.
Adverse drug reactions: current issues and strategies for prevention and management

Adverse drug reactions (ADRs) are common, frequently serious and cause considerable morbidity and mortality. In addition to human costs, ADRs place considerable economic burden on society and already-stretched healthcare systems. Much work has been done to determine potential causes, commonly responsible drugs and susceptible patient groups. To this end, various national pharmacovigilance schemes exist to collate information about ADRs. Despite this, levels of ADR reporting are universally poor, with ADRs remaining a significant clinical problem. Therefore, more effective dissemination and implementation of available knowledge is needed, together with better use of the systems already in place. Local ADR centres and teams, in close liaison with national centres, appear to be an important part of this process and need to be developed within healthcare systems. In addition, there is now evidence to suggest that better use of informatics will help to facilitate this, together with wider availability of electronic notes and greater use of computer-prescribing. Although advancing technology may help to make the use of medicines safer, more effective and more specific in the future, investment to develop informatics infrastructure and local ADR teams is now needed in our healthcare systems.
Boolean minimization and algebraic factorization procedures for fully testable sequential machines

The authors present a novel Boolean minimization procedure of prime-implicant generation and constrained covering based on the Quine-McCluskey algorithm. On completion, it guarantees a prime and irredundant, fully testable Moore or Mealy finite state machine. Given a two-level circuit with these properties, constrained algebraic factorization techniques are used that retain the invariant that no single fault can both produce an invalid state and corrupt the distinguishing sequence by which that invalid state is detected. Besides offering a more detailed understanding of the sources of untestability in sequential circuits than previous approaches, this approach offers significant practical advantages as well. It is applicable to a wider range of circuits than optimal synthesis procedures whose utility is often limited by prohibitively high CPU requirements, and its less restrictive synthesis constraints result in lower area overhead than other constrained synthesis approaches. These observations are supported by experimental results. <<ETX>>
Counterpoint: Are Insulin Pumps Underutilized in Type 1 Diabetes? No

One of the major goals in the treatment of diabetes is to achieve an HbA1c (A1C) 200,000 worldwide (3). This article will address one specific question, i.e., whether a major effort should be made to increase the number of patients on insulin pumps in order to achieve the above-stated A1C goal. There are several factors that determine plasma glucose concentration. These include 1 ) the carbohydrate composition of food, 2 ) the rate of gastric emptying, 3 ) the rate of glucose absorption, 4 ) the concurrent magnitude of endogenous glucose production, 5 ) the concurrent rate of glucose disposal, 6 ) the diurnal change in insulin sensitivity, 7 ) the activity of counterregulatory hormones, 8 ) the change in the magnitude and type of exercise, and 9 ) the ambient insulin concentration. It is important to note that most of these factors are not directly under the patient’s control. Many of the factors are interrelated, so that altering one may affect the magnitude of the other. Thus, in attempting to normalize plasma …
Identifying Corporate Social Responsibility (CSR) Curricula of Leading U.S. Executive MBA Programs

Our society has witnessed large enterprises collapse from a disregard for Corporate Social Responsibilities (CSR) and illegal and unethical comportments. This chapter provides an understanding of the basic concepts of CSR in the context of lawful and ethical responsibilities, while recognizing the power of CSR branding. Moreover, in accordance with the theory that higher education can elevate the importance of CSR strategies, it reports the results from a qualitative content analysis study identifying explicit and implicit inclusions of CSR, law, and ethics in course titles and descriptions from 20 leading Executive Master of Business Administration (MBA) programs at institutions of higher education in the United States. The results report that while law and ethics are commonly part of the reviewed Executive MBA programs, CSR has minimal representation in these programs.
Dendritic Fibrous Nanosilica for Catalysis, Energy Harvesting, Carbon Dioxide Mitigation, Drug Delivery, and Sensing

Abstract Morphology‐controlled nanomaterials such as silica play a crucial role in the development of technologies for addressing challenges in the fields of energy, environment, and health. After the discovery of Stöber silica, followed by that of mesoporous silica materials, such as MCM‐41 and SBA‐15, a significant surge in the design and synthesis of nanosilica with various sizes, shapes, morphologies, and textural properties has been observed in recent years. One notable invention is dendritic fibrous nanosilica, also known as KCC‐1. This material possesses a unique fibrous morphology, unlike the tubular porous structure of various conventional silica materials. It has a high surface area with improved accessibility to the internal surface, tunable pore size and pore volume, controllable particle size, and, importantly, improved stability. Since its discovery, a large number of studies have been reported concerning its use in applications such as catalysis, solar‐energy harvesting, energy storage, self‐cleaning antireflective coatings, surface plasmon resonance‐based ultrasensitive sensors, CO2 capture, and biomedical applications. These reports indicate that dendritic fibrous nanosilica has excellent potential as an alternative to popular silica materials such as MCM‐41, SBA‐15, Stöber silica, and mesoporous silica nanoparticles. This Review provides a critical survey of the dendritic fibrous nanosilica family of materials, and the discussion includes the synthesis and formation mechanism, applications in catalysis and photocatalysis, applications in energy harvesting and storage, applications in magnetic and composite materials, applications in CO2 mitigation, biomedical applications, and analytical applications.
Modulation of 5‐fluorouracil toxicity by allopurinol in man

Oxipurinol, the major metabolite of allopurinol, decreased the toxicity of 5‐fluorouracil (5‐FU) to human granulocyte colony‐forming units in vitro by a factor of four. The ability of allopurinol to reduce 5‐FU toxicity in vivo was studied in 23 advanced cancer patients during 42 courses of treatment. 5‐FU was administered by continuous intravenous infusion for five days; allopurinol, 300 mg, po, every 8 hours was started 2 hours before and continued during and for 24 hours after 5‐FU infusion. 5‐FU was escalated from 1.5 to 2.25 g/m2/day on separate courses; the dose‐limiting toxicity was mucositis which occurred at a level of 2.0 g/m2/day. At a 5‐FU dose rate of >2.0 g/m2/day 5‐FU pharmacokinetics were nonlinear, reflecting saturation of catabolic pathways, and the steady‐state 5‐FU serum concentration was approximately 4 times that which was tolerable without allopurinol. At these concentrations of 5‐FU oxipurinol significantly influenced the clearance of 5‐FU. Thus concurrent allopurinol therapy permitted a doubling of the maximum tolerated dose of 5‐FU and a four‐fold increase in the tolerated concentration x time exposure to 5‐FU.
A Study on How Mobile Banking Has Affected the Banking Industry: Has Mobile Banking Improved Bank Performance?

This paper explores the effect of mobile banking on the banking industry. It further seeks to investigate if banks improve financial performance as well as customer conversion and retention due to mobile banking. The research sifts through early entries in mobile banking features, data transfer technology evolution along with hand-held mobile device advances. Population demographics are also reviewed to understand which segment is more inclined to use mobile banking applications, giving banks insights and analytics for focused advertising. Data security needs and bank personnel skills evaluation show a shift in personnel skill-set evolution from historical employees. Overall, the data suggests that bank performance does improve on the balance sheet and in customer conversion/retention when the bank has leading-edge mobile banking features along with disciplined cost reduction in front-line tellers and reduction in brick-and-mortar investments.
Assessing risk of venous thromboembolism in the patient with cancer.

PURPOSE Patients with cancer are increasingly at risk for venous thromboembolism (VTE). Rates of VTE, however, vary markedly among patients with cancer. DESIGN This review focuses on recent data derived from population-based, hospital-based, and outpatient cohort studies of patients with cancer that have identified multiple clinical risk factors as well as candidate laboratory biomarkers predictive of VTE. RESULTS Clinical risk factors for cancer-associated VTE include primary tumor site, stage, initial period after diagnosis, presence and number of comorbidities, and treatment modalities including systemic chemotherapy, antiangiogenic therapy, and hospitalization. Candidate predictive biomarkers include elevated platelet or leukocyte counts, tissue factor, soluble P-selectin, and D-dimer. A recently validated risk model, incorporating some of these factors, can help differentiate patients at high or low risk for developing VTE while receiving chemotherapy. CONCLUSION Identifying patients with cancer who are most at risk for VTE is essential to better target thromboprophylaxis, with the eventual goal of reducing the burden as well as the consequences of VTE for patients with cancer.
Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates

Abstract To date, most antibodies from combinatorial libraries have been selected purely on the basis of binding. However, new methods now allow selection on the basis of function in animal cells. These selected agonist antibodies have given new insights into the important problem of signal transduction. Remarkably, when some antibodies bind to a given receptor they induce a cell fate that is different than that induced by the natural agonist to the same receptor. The fact that receptors can be functionally pleiotropic may yield new insights into the important problem of signal transduction.
The Interactive Management Of Human Resources In Uncertainty

Thank you very much for reading the interactive management of human resources in uncertainty. As you may know, people have search numerous times for their favorite novels like this the interactive management of human resources in uncertainty, but end up in harmful downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they are facing with some infectious bugs inside their laptop.
Collaborating with Complementors: What Do Firms Do?

The study considers the interdependencies between complementors in the business ecosystem and explores the nature of collaborative interactions between them. It sheds light on the organizational and the strategic contexts in which such interactions take place, and shows how they may influence the pattern and the benefits of collaboration. The evidence presented is based on fieldwork followed by a detailed survey instrument administered to firms in the semiconductor industry. The findings, while reinforcing the shift in the locus of value creation from focal firms to collaborative business ecosystems characterized by information sharing and joint action among complementors, illustrate the organizational and the competitive challenges that firms face in their pursuit of joint value creation.
Analytical threshold voltage model of gate all around triple metal tunnel FET

We analytically modeled the threshold voltage expression of Gate All Around Tripe Metal (GAATM) Tunnel FET in the present research endeavor. We have used the Trans-conductance Change Method (TCM) for extracting the threshold voltage of the GAATM TFET. The three different metals with different work functions are incorporated over the channel region, which helps to curb the ambipolar conduction and boost the ON current. The variability issues on the threshold voltage (Vth) are also studied and optimized the proposed GAATM TFET in terms of smaller Vth.
Changing FHA Mortgage Insurance Premiums and the Effects on Lending

This note explores the effect of changes in Federal Housing Administration (FHA) mortgage insurance premiums (MIP) on mortgage borrowing activity. Reacting to changing conditions in the mortgage market as well as the state of its own balance sheet, the FHA has adjusted its pricing rules a number of times in the wake of the financial crisis.
A new genetic variant of Chlamydia trachomatis

A thrilling story in Sweden, with global impact A new variant of Chlamydia trachomatis was discovered in Sweden in 2006. This variant contains a mutant sequence that cannot be detected with either the Abbott m2000 (Abbott Diagnostics, Chicago, IL, USA) or Cobas Amplicor/TaqMan48 (Roche Diagnostics, Basel, Switzerland) systems.1 The first description reported that the new variant constituted 13% of all detected chlamydia infections (from mid-September to October 2006) in the county of Halland (south west of Sweden). It soon became apparent that the proportion was higher and that the new variant had spread widely in Sweden.2–4 We now know that in the counties that have used the Abbott or Roche test systems during the past year or so the new variant accounts for 20% to 65% of all detected chlamydia cases. In local areas, as many as 78% of all cases have been found to have the mutation (Britta Lore, personal communication). How great is the national impact of this emerging variant of C trachomatis ? As in many other countries chlamydia rates have increased in Sweden during the past 10 years. However, for 2006 the national figures showed a reversal of this trend.5 The 2% decrease in reported cases was because of the inability of some diagnostic systems to detect the new variant. Counties using the Abbott or Roche test systems reported fewer chlamydia cases in 2006 compared to 2005, while counties using methods that detected the strain, mainly the BectonDickinson ProbeTec, reported an increase. In a preliminary analysis, if we assume …
Internet of Things context of the smart city

This paper deals with the Internet of Things solutions and value chain related to the Smart City domain. Characterization of the IoT services and applications including connectivity requirements is proposed and illustrated with two case studies, on smart parking and air quality monitoring based on urban crowd sensing. Regulatory issues, as well as the role of the national regulatory authority for electronic communications are presented.
A general query middleware based on web service

Data query plays an important role in the information application system. Data query in the traditional design method need to be constantly redesigned with the change of user requirements, which increases the workload of system development, reducing development efficiency and software reuse. After abstracting and extracting the common elements of the query, a scalable, flexible configuration, reusable general query middleware based on web service technology is designed. General query middleware consists of two parts. One is the query configuration module for the system designers. Another is the general query module for end-users. System designers and end-users need only some simple operations to achieve integrated query function, reducing duplication of code and improving development efficiency.
Suppression of nonadiabatic losses of molecules from chip-based microtraps

Polar molecules in selected quantum states can be guided, decelerated, and trapped using electric fields created by microstructured electrodes on a chip. Here we explore how nonadiabatic transitions between levels in which the molecules are trapped and levels in which the molecules are not trapped can be suppressed. We use {sup 12}CO and {sup 13}CO (a {sup 3{Pi}}{sub 1},v=0) molecules, prepared in the upper {Lambda}-doublet component of the J=1 rotational level, and study the trap loss as a function of an offset magnetic field. The experimentally observed suppression (enhancement) of the nonadiabatic transitions for {sup 12}CO ({sup 13}CO) with increasing magnetic field is quantitatively explained.
The immunological classification of acute lymphoblastic leukemias

The main methods used in order to assess the immunological markers on the blast cells from patients with acute lymphoblastic leukemia (ALL) are critically evaluated. The classification of ALL according to the phenotype of the leukemic cells and their presumed origin is reviewed. The correlations with clinical features and prognosis, as well as their possible therapeutic implications, are discussed.
P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808.

Cancer and Leukemia Group B 19808 (CALGB 19808) is the only randomized trial of a second-generation P-glycoprotein (Pgp) modulator in untreated patients with acute myeloid leukemia (AML) younger than age 60 years. We randomly assigned 302 patients to receive induction chemotherapy regimens consisting of cytosine arabinoside (Ara-C; A), daunorubicin (D), and etoposide (E), without (ADE) or with (ADEP) PSC-833 (P). The incidence of complete remission was 75% with both regimens. Reversible grade 3 and 4 liver and mucosal toxicities were significantly more common with ADEP. Therapy-related mortality was 7% and did not differ by induction arm. Excess cardiotoxicity was not seen with high doses of D in ADE. The median disease-free survival was 1.34 years in the ADE arm and 1.09 years in the ADEP arm (P = .74, log-rank test); the median overall survival was 1.86 years in the ADE arm and 1.69 years in the ADEP arm (P = .82). There was no evidence of a treatment difference within any identifiable patient subgroup. Inhibition of Pgp-mediated drug efflux by PSC-833 did not improve clinical outcomes in younger patients with untreated AML. This trial was registered at www.clinicaltrials. gov as #NCT00006363.
Diffuse large B‐cell lymphoma: is morphologic subdivision useful in clinical management?

Abstract: The diffuse large B‐cell lymphoma category of the REAL classification encompasses different morphologic lymphoma subtypes in a single entity. The aim of this study is to determine the influence of the morphologic subdivision within this category with respect to clinical features and response to treatment. From January 1993 to October 1996, 132 patients were diagnosed de novo with diffuse large B‐cell lymphoma in our institution. All cases were classified according to the REAL and the Updated Kiel classifications, and immunohistochemical study was performed in all of them. Sixty‐three per cent of patients received chemotherapy with a curative approach. Of the 105 assessable patients, 80 cases (74%) were classified as centroblastic (CB) and 25 cases (26%) as immunoblastic (IB), according to the updated Kiel classification. These 2 subsets of lymphomas did not differ with respect to major clinical features and laboratory parameters. Both groups had a similar complete response rate with a uniform therapeutic approach and the overall 2‐yr survival did not show statistical differences (49% in CB vs. 45% in IB). In conclusion, for clinicians, morphologic subdivision of the diffuse large B‐cell lymphoma category into CB and IB subtypes has little clinical and prognostic significance.
Clustering of Negative Affectivity and Social Inhibition in the Community: Prevalence of Type D Personality as a Cardiovascular Risk Marker

Objective: To explore the prevalence of Type D personality—the combination of negative affectivity and social inhibition—in the general population and its relationship to other cardiovascular risk factors, including psychopathological symptoms. Type D personality has been identified as a prognostic risk factor for various cardiovascular disease conditions. Methods: In a representative sample of 2698 individuals (aged 35–74 years), psychological, lifestyle, and somatic risk factors were investigated with laboratory testing, self-report measures, and a clinical interview. Type D was assessed with the German Type D Scale-14. Results: The prevalence of Type D was 23.4% (95% confidence interval [CI], 21.2–25.6) in men and 26.9% (95% CI, 23.7–30.1) in women and, thus, in the range of classical risk factors (e.g., hypercholesterolemia). In age-adjusted analysis, Type D was associated with psychopathological symptoms, including depression and somatic symptom burden. With the exception of physical inactivity in both sexes, hypertension in women and hypercholesterolemia in men, Type D was not associated with classical cardiovascular risk factors. Multivariate analysis revealed depression, exhaustion, anxiety, and low self-rated health as associated with Type D in both sexes (odds ratios, 1.97–3.21 in men, 1.52–2.44 in women). Conclusions: A Type D personality disposition can be found in about a quarter of the general population, which is comparable to the prevalence of classical cardiovascular risk factors. In both sexes, an independent association to Type D appeared mainly in psychopathological symptoms. Type D constitutes a relevant and independent risk marker in the community and should receive attention in clinical practice. CAD = coronary artery disease; CHD = coronary heart disease; DS14 = Type D Scale-14; NA = negative affectivity; HADS = Hospital Anxiety and Depression Scale; KORA = Cooperative Health Research in the Augsburg Region, Germany; MI = myocardial infarction; PHQ-9 = Patient Health Questionnaire depression module; SI = social inhibition; PTSD = posttraumatic stress disorder; TNF = tumor necrosis factor.