Miracle-dz/UniFAR-FTUs huggingface dataset:
Sexual dimorphism of AMBRA 1-related autistic features in human and mouse

Ambra1 is linked to autophagy and neurodevelopment. Heterozygous Ambra1 deficiency induces autism-like behavior in a sexually dimorphic manner. Extraordinarily, autistic features are seen in female mice only, combined with stronger Ambra1 protein reduction in brain compared to males. However, significance of AMBRA1 for autistic phenotypes in humans and, apart from behavior, for other autism-typical features, namely early brain enlargement or increased seizure propensity, has remained unexplored. Here we show in two independent human samples that a single normal AMBRA1 genotype, the intronic SNP rs3802890-AA, is associated with autistic features in women, who also display lower AMBRA1 mRNA expression in peripheral blood mononuclear cells relative to female GG carriers. Located within a non-coding RNA, likely relevant for mRNA and protein interaction, rs3802890 (A versus G allele) may affect its stability through modification of folding, as predicted by in silico analysis. Searching for further autism-relevant characteristics in Ambra1 mice, we observe reduced interest of female but not male mutants regarding pheromone signals of the respective other gender in the social intellicage set-up. Moreover, altered pentylentetrazol-induced seizure propensity, an in vivo readout of neuronal excitation–inhibition dysbalance, becomes obvious exclusively in female mutants. Magnetic resonance imaging reveals mild prepubertal brain enlargement in both genders, uncoupling enhanced brain dimensions from the primarily female expression of all other autistic phenotypes investigated here. These data support a role of AMBRA1/ Ambra1 partial loss-of-function genotypes for female autistic traits. Moreover, they suggest Ambra1 heterozygous mice as a novel multifaceted and construct-valid genetic mouse model for female autism.
Does certification work in emerging markets? evidence from the Indian IPO market

There is inconclusive evidence regarding the economic value of certification in the context of IPOs in developed markets. Using a natural experiment of regulator mandated IPO grading requirement, we examine the effects of third-party certification in the Indian IPO market. We summarize our empirical results below. First, underpricing is unaffected by the grading process. Second, stock price informativeness as proxied by idiosyncratic volatility increases significantly due to IPO grading process. Third, retail and institutional subscription levels are significantly positively associated with IPO grades after controlling for other certification mechanisms such as underwriter reputation, group affiliation, analyst recommendation and venture capital backing. Finally, using a pseudo grading process we conclude that IPO grades are not mechanically derivable from publicly available information. In a nutshell, we use our unique setting to examine the usefulness of certification in emerging markets with institutional voids.
An alternative parameterization of eddy diffusivity in the Gulf of Finland based on kinetic energy of high frequency internal wave band

In July 1998, three time series of shear microstructure measurements (duration 13, 24 and 14 h, respectively) were performed in 3 different wind-forcing regimes as well as in 3 different background density stratification and current velocity shear situations at the entrance to the Gulf of Finland. We compared the “measured” eddy diffusivities with the diffusivities parameterized using the Richardson number, the Brunt-Väisälä frequency and with the diffusivities simulated using the two-equation k-ε turbulence closure. Summing up the discrepancy of all three time series, the methods applied resulted in a remarkable and consistent bias against the measured eddy diffusivity. Contrary to this result, the calculations with the new suggested parameterization scheme, which accounts for the internal wave kinetic energy of the super-inertial frequency band, fitted well for all three time series. Similarly, the modified k-ε simulations accounting for the super-inertial internal wave energy matched better the measured profiles.
Innovative Approach to Doctor-patient Relationship Management: Based on TRIZ Theory

Modern doctor-patient relationship is characterized by tension, indirectness, diversity, complication, changeability and systematicness. At present, the research on doctor-patient relationship in China tends to be diversified in theory, but there is a contradiction phenomenon in resolving doctor-patient conflict. This paper introduces the TRIZ theory , systematically analyzes and deconstructs the method system and basic flow of TRIZ theory, discusses the feasibility of TRIZ theory in the doctor-patient relationship management, and the logical paradigm of solving the problem of doctor-patient relationship based on TRIZ theory, puts forward a kind of innovative method of doctor-patient relationship management.
Using modified triage system to improve emergency department efficacy: A successful Lean implementation

ABSTRACT Introduction: Most emergency departments in rural hospitals practice single-tier triage system. We propose adding a secondary triage, a 2-tier triage system that can improve the department efficacy. Methods: This was a single-centre pre–post-interventional study conducted in a district emergency department. During pre-interventional phase, patients were triaged by usual practice using single-tier system. For post-interventional phase, a secondary triage was added. A physician was also added to the secondary triage during peak hours. All patients who came during pre- and post-intervention phases were recruited for analysis. The primary outcomes were department length of stay (LOS) and left without being seen (LWBS) rate. Results: There were 5007 patients (pre-intervention period) and 4970 patients (post-intervention period) recruited for data analysis. Intervention had reduced the overall LOS from 106 to 85 min (mean, p < 0.001). Subgroup analysis showed reduced LOS for non-critical cases from 72 to 45 min (mean, p < 0.001), but no significant improvement for critical and semi-critical cases. The LWBS rate was also reduced from 4.1% to 2.0% (p < 0.001). Conclusions: Secondary triage system with an addition of physician during peak hours has been proven to improve emergency department LOS and LWBS rate.
Treatment Results of Vulvar Intraepithelial Neoplasia in 16 Women

OBJECTIVE: Clinical outcome after surgical treatment of vulvar intraepithelial neoplasia (VIN). STUDY DESIGN; 16 women with vulvar intraepithelial neoplasia were reviewed. Histologic diagnosis was based on classification of the International Society for the Study of Vulvovaginal Diseases (ISSVD). RESULTS: All cases had unifocal lesions in vulvar examination. In 13 cases (81,5%) lesions were white, in 2 cases (12,5%) lesions were papillary in apprereance and in a case ( 6%) there was an ulcerative lesion. In all cases diameter of the vulvar lesions were less than 2 cm. Local excision was performed for VIN 1 lesions. VIN2 and VIN3 lesions underwent simple vulvectomy. Imiquimod therapy was prefferred for a case with VIN3 lesion who refused surgery. In a case with VIN3 lesion squamous cell carcinoma in situ diagnosed after vulvectomy operation. Recurrence of disease has not yet been diagnosed during the follow up period. CONCLUSION: VIN lesions should be surgically treated and careful long term surveillence is mandatory.
3 D-Printed 96 GHz Bull ’ sEye Antenna with Off-Axis

Reducing the profile, footprint and weight of antennas embarked on aircrafts, drones or satellites has been a long pursued objective. Here we tackle this issue by developing a millimeter-wave 96 GHz elliptical Bull’s-Eye antenna with offaxis radiation at 16.5o that has been fabricated by low cost 3D printing stereolithography, followed by metal coating. The theoretical basis for optimum off-axis operations is explained. Measurement results show an overall good agreement with simulations, displaying a gain of 17 dB and a 3.5o beamwidth (Eplane) at the operational frequency. The off-axis beaming enlarges the potential applicability of this technology with respect to the broadside beam solution.
Overview of the Human Investigations of Nigella sativa (Black Seeds): A Complementary Drug with Historical and Clinical Significance

1International Drug Development Consultants Corporation, Long Grove, Illinois, USA 2Stritch School of Medicine, Department of Medicine, Loyola University, Chicago, Illinois, USA 3Western Michigan University School of Medicine, Kalamazoo, Michigan, USA 4Bronson Hospital, Kalamazoo, Michigan, USA 5Mary Free Bed, Grand Rapids, Michigan, USA 6Premier Radiology, Kalamazoo, Michigan, USA 7Borgess Hospital, Kalamazoo, Michigan, USA
Epistemic uncertainties and natural hazard risk assessment ­ Part 1: A review of the issues

Abstract. Uncertainties in natural hazard risk assessment are generally dominated by the sources arising from lack of knowledge or understanding of the processes involved. There is a lack of knowledge about frequencies, process representations, parameters, present and future boundary conditions, consequences and impacts, and the meaning of observations in evaluating simulation models. These are the epistemic uncertainties that can be difficult to constrain, especially in terms of event or scenario probabilities, even as elicited probabilities rationalized on the basis of expert judgements. This paper reviews the issues raised by trying to quantify the effects of epistemic uncertainties. Such scientific uncertainties might have significant influence on decisions that are made for risk management, so it is important to communicate the meaning of an uncertainty estimate and to provide an audit trail of the assumptions on which it is based. Some suggestions for good practice in doing so are made.
Survey Paper on Analyze and Predict the Nature of Road Traffic Accidents using Data Mining Techniques in Maharashtra, India

— Traffic accidents are the main cause of death as well as serious injuries in the world. India is among the emerging countries where the rate at which traffic accident occurs is more than the critical limit. Due to this reason difficult to know the nature of road traffic accidents. As a human being, we all want to avoid traffic accidents and stay safe. In order to stay safe, careful analysis of roadway traffic accident data is important to identify the nature of traffic accident that causesfatal and series injuries. Analysis of road traffic accidents is significantto expose the association between the various types of factors thatinfluencethe nature of road traffic accidents. For this purpose, there are a number of classification and association rule mining algorithms available to analyze, detect and predict the road accident historical data and to obtained hidden patterns from huge data. From these, this survey paper discusses the algorithms and data mining tools that areproved better in theprevious studies.
Influence of sex on performance, carcass traits and economic feasibility of cattle fed high grain diets.

Objetivou-se avaliar o efeito do sexo sobre o desempenho, as caracteristicas de carcaca e a viabilidade economica da terminacao de bovinos alimentados com dieta de alto grao. O experimento foi conduzido na fazenda Manaus, municipios de Itaju do Colonia, localizado na regiao sul da Bahia. Foram utilizados 40 bovinos da raca Nelore, 20 novilhos nao castrados e 20 novilhas, separados de acordo com os tratamentos: machos e femeas organizados no delineamento inteiramente ao acaso. Nao foram observadas diferencas estatisticas de desempenho (P>0,05), exceto para conversao alimentar e eficiencia alimentar (P 0,05). O custo total com os machos foi superior ao obtidos para as femeas (P<0,05). Nao houve diferenca na rentabilidade e lucratividade (P<0,05). Machos e femeas apresentam mesmo desempenho quando alimentados com dietas de alto grao, no entanto femeas apresentam melhor cobertura de gordura. Uso de macho e femeas em confinamentos de alto grao sao viaveis economicamente.
On the role of coherent and stochastic fluctuations in the evolving solar wind MHD turbulence: Intermittency

One of the most interesting findings about solar wind turbulence is the intermittent character of its fluctuations. So far, intermittency has been studied, within solar wind context, only for scalar quantities neglecting to include in the study also vector fluctuations. In this paper we compare magnetic field and wind velocity intermittency computed for both scalar and vector fluctuations. We confirm that intermittency generally increases with radial distance from the sun only for fast wind and we suggest that at the basis of this behavior is a competing action between coherent structures imbedded in the wind and Alfvenic stochastic fluctuations propagating within the wind. The radial evolution experienced by these two components is rather different and consistent with the observed radial increase of intermittency in the inner heliosphere.
Role of gene polymorphism of IL-4 and IL-17 in recurrent miscarriage, came in art cycles

Most researchers suggest that more than 50% of pregnant women after use of assisted reproductive technologies (ART) are faced with the problem of miscarriage, especially in the first trimester. The aim of the study was to investigate the frequency of genotypes and allelic variants of the IL-4 (S589T and S33T), IL-4R (Q576R), IL-17A (G197A) and IL-17F (488T/C) genes, depending on the reproductive status and assessment of their association with recurrent miscarriage, which occurred in ART cycles. Peripheral blood of 240 patients – the eastern Slav with habitual miscarriage, came in ART cycles, and 100 apparently healthy fertile women in the control group with a history of at least one term delivery and lack of spontaneous abortion episodes was studied. The groups were representative of age. DNA for molecular genetic studies of nuclei isolated from peripheral blood lymphocytes. The method is based on the destruction of lymphocytes using lysis buffer without affecting the integrity of the membranes of lymphocytes nuclei. For typing single nucleotide polymorphisms of IL-4 immune response, IL-4R, IL-17A and IL-17F using polymerase chain reaction product with the melting reaction in the presence of “adjacent” oligonucleotides. It was found that the genotype CT-33 (OR 3.99; 95% CI 2,42–6,57) and CT-589 (OR 3.99; 95% CI 2,42–6,57) gene IL-4; genotype GG576 (OR 5.95; 95% CI 1,39–25,58) gene IL-4R and TT488 genotype (OR 2.33; 95% CI 1,39–3,91) and CC488 (OR 2.27; 95% CI 0,76–6,84) IL-17F gene were associated with a significant increase in the risk of miscarriage. On the other hand, no significant differences were found between the control group and the basic frequency of polymorphisms IL-17A-G197A (rs227593). The results of the molecular-genetic typing it possible to identify in the Eastern Slavic population of residents of Odesa region of Ukraine immunogenetic markers of susceptibility/ resistance to the development of recurrent miscarriage. It is shown that cytokine gene typing can be used as a method of early diagnosis and pregravid prognosis of immune forms of reproductive loss in women.
Biodiversity ecosystem functioning research in freshwater phytoplankton: A comprehensive review of trait-based studies

In an effort to reach a clearer mechanistic understanding of the influence of biological diversity on ecosystem functioning, research in the field is increasingly applying a trait-based approach. In this comprehensive review, I searched for and analyzed studies that focused on the relationship between biodiversity and ecosystem functioning (BEF) using a trait-based approach in freshwater phytoplankton from lentic systems (lakes, ponds, reservoirs). I found that this type of studies is very rare and included a plethora of traits, diversity metrics, statistical analyses and study locations that contributed to the high variability in the results they obtained. Overall, trait-based diversity is not a very good predictor of ecosystem functioning in freshwater lentic ecosystems. Null relationships between trait-based diversity and ecosystem functioning in freshwater lentic systems were the more frequent outcome. When significant, the amount of variation in ecosystem functioning explained by trait-based diversity was small. Still, trait-based research remains a promising approach to increase the mechanistic understanding of BEF relationships. For this purpose, studies directly testing the underlying mechanistic rationale, exploring diversity effects on the temporal stability of ecosystem functions, including multiple functions at a time, focusing more in cell size and shape and confirming the relative importance of individual trait variation for ecosystem functioning are needed.
INDUCTION OF FEEDING PREFERENCE IN LARVAE OF THE PATCH BUTTERFLY, CHLOSYNE LACINIA

Induction of preference, a phenomenon first described by TIBOR JERMY, was demonstrated in larvae of the patch butterfly, Chlosyne lacinia. Using choice tests pioneered by JERMY (the “disc test”) to assay preferences, a strong induction was shown with three plant pairs. Several factors affecting induction were investigated: critical time windows, switching food plants, the amount of feeding necessary to produce a change in preference, and the effect of feeding just prior to the choice test. No early critical window (“imprinting”) was found; both the amount and recency of feeding were found to be significant factors for induction and may interact. The importance of the induction of preference is discussed.
Evaluation of a Prototype Desktop Virtual Reality Model Developed to Enhance Electrical Safety and Design in the Built Environment

The use of Desktop Virtual Reality (VR) systems for enhancing electrical safety and engineering design is a novel prospect for both practicing and student electrical services engineers. This innovative approach, which can be readily accessed via the World Wide Web, constitutes a marked shift in conventional learning and design techniques to a more immersive, interactive and intuitive working and learning environment. This paper initially identifies the unique characteristics of desktop web based VR technologies and highlights the educational affordances offered by working in such an environment. Subsequently, using a prototype model titled ‘Virtual Electrical Services’, a case study is carried out to evaluate the users’ attitudes toward VR learning environments and also the usability of the prototype model developed. From the completed case study, it appears that the users perceive the prototype to be a useful tool and are receptive to using VR as a learning and design tool. The paper includes a discussion on the limitations of the system developed and the implications for
Evaluation of Local Effects of Transitional Knudsen Number on Shock Wave Boundary Layer Interactions

The influence of the local effects of rarefaction on the prediction of the main parameters typical of Shock Wave - Boundary Layer Interaction are presented and analyzed. Slip flow boundary conditions have been implemented in CIRA CFD code H3NS, and results have been compared with available wind tunnel experiments and DSMC results. Finally, an experimental wind tunnel test case, planned in CIRA Plasma Wind Tunnel facility, has been analyzed in order to check possible local effects of rarefaction.
Autobiographical amnesia following Arteriovenous Malformation, case report

Aim : The aim of the current study is the description of an emblematic case of a ruptured left temporal arteriovenous malformation (AVM) causing a large intraparenchymal temporo-parietal left hematoma that resulted in a severe retrograde amnesia. Methods : The patient underwent neurosurgical evacuation of the hematoma and resection of the AVM. He was also sumbitted to several pre- and post-operative neuropsychological evaluations and to rehabilitation for different subdomains of both memory and language. Results : At the end of the rehabilitation course, a new neuropsychological assessment was performer together with a functional cortical mapping Navigated Transcranial Magnetic Stimulation (nTMS) to evaluate the focal damage to and the plastic recovery of language cortical areas. Discussion : This case report must be ecologically oriented and based on the relationship between the importance and the nature of the cognitive and type of claims of the specific environment of the individual; that a rehabilitative path cannot ignore a holistic approach that considers the effects of the injury on the emotional and psychosocial states of the person and his family members.
World Experience of Using Water Reservoirs in the Structure of Basic Horizontal Planes of an Architectural Object

The aim of the article is to popularize the ecological approach in building both in Ukraine and states of the former Soviet Union. Previously the author studied issues of using water as a natural component on local and object levels in the structure of basic horizontal planes as connecting and outer spaces. This article deals with basic horizontal planes of buildings. The author analyzed architectural objects containing water as a natural component in their structure, and considered quality features of this approach. Firstly, these features influence psychology and physiology of a person, aesthetic perception of architectural objects and secondly, they have ecological aspects such as solving problems of heat isolation, precipitation cleansing, reducing the level of air pollution, atmospheric dispersion, etc. The article is based on the world experience of using water reservoirs in the structure of an architectural object. The author determined methods of water use and its influence on architectural form making. Watermorphic approach in architecture is defined as self-sufficient.
TÜ Kliinikumi ühendlaboris isoleeritud anaeroobide spekter ja ravimitundlikkus

2001. –2006. a analuusiti TU Kliinikumi uhendlaboris kliinilistest materjalidest isoleeritud anaeroobide ruhmi ja antibiootikumitundlikkust ning vorreldi neid parodontiidi patogeenide sarnaste andmetega. Kliinilistest materjalidest isoleeritud anaeroobsetest parodontiidi patogeenidest olid sagedasemad prevotellad ja fusobakterid. Anaeroobide antibiootikumitundlikkus oli suhteliselt korge. Metronidasool toimis hasti gramnegatiivsetesse pulkbakteritesse, kuid grampositiivsed kokid olid resistentsemad. Klindamutsiin ja ampitsilliin/sulbaktaam olid tohusad koikide anaeroobiruhmade suhtes. Beetalaktamaasi produtseerivate mikroobide osakaal oli 7–54%. Sagedasemad beetalaktamaasi suhtes positiivsed mikroobid olid Porphyromonas spp. ja Prevotella spp. Parodontiidi anaeroobsed patogeenid osutusid kliinilistest isolaatidest antibiootikumitundlikumateks. Eesti Arst 2008; 87(11):834−840
Assessment of Quality-related Risks by the Use of Complex Networks

Abstract This study introduces the NTS network as a new way of analysing, verifying and improving quality-related risk assessment. NTS is based on a network science approach that models complex systems by graphs. By using N, T and S-Graphs as the elements of NTS, risk events that play special role in the risk management system can be identified. Based on their characteristics, the strength of their potential causal connections can be recalculated, providing more precise predictions of the occurrence frequencies of events. Kivonat - Minőségi kockázatok elemzése komplex hálózatok segítségével. A tanulmány bemutatja a minőségügyi kockázatok közötti kapcsolatok elemzésére használható NTS hálózatot, amelynek segítségével - a kockázati események valós előfordulása alapján - értékelhetők és javíthatók a minőségi kockázatok elemzésének eredményei. Az NTS alkalmazása a hálózattudomány újszerű megközelítésén alapul, amely gráfok segítségével modellezi a komplex rendszereket. Az NTS elemeinek, az ún. N-, T- és S-gráfoknak a használatával azonosíthatók azok a kockázati események, amelyek speciális szerepet játszanak a kockázatmenedzsment rendszerben. Ismerve a jellegzetességeiket, az események közötti potenciális okozati kapcsolatok újraértékelhetők, amelynek eredményeképpen megbízhatóbb előrejelzés adható az egyes események előfordulási gyakoriságára.