Miracle-dz/UniFAR-FTUs huggingface dataset:
10-Gbps true random number generator accomplished in ASIC

Random number generators are wildly used in many applications in a diverse set of areas ranging from statistics to cryptography. Pseudo random number generators (PRNGs) are quite satisfactory for most applications. However, for cryptography and security applications, true random number generators (TRNGs) are required for the unpredictability. High density and high data output rate are as important as the quality of the TRNG in the nowadays true random number required devices and instruments. We present the design and the primary test results of our 10-Gbps TRNG, which is named TRNG2015, in the paper. The entropy source of the TRNG2015 is the jitter of ring oscillators. The TRNG2015 is fabricated in a 130nm CMOS process and assembled in a 6mm × 6 mm QFN48 package. It has one LVDS clock input and ten LVDS random data outputs. The output data rate depends on the input clock which is up to 1 GHz, and the output data rate is up to 1 Gbps per channel and up to 10 Gbps in total.
Proposta de modelo de migração de sistemas de ambiente tradicional para nuvem privada para o Polo de Tecnologia da Informação do Exército brasileiro

Cloud computing is no longer a myth for organizations, on the contrary. Large companies have already migrated their systems to the cloud in search of its beneficts. The cloud computing business model has provided hosting and use of public infrastructure on the Internet to create their own cloud infrastructure within the organization’s premises in a private cloud model so called. With the creation of the Brazilian Army Information Technology Pole, they also understands that migration to a cloud environment can help to improve the provision of services to its internal customers, modernizing its infrastructure. Given the Army’s business sensitivity it is understood that the need for modernization should be aligned to the private cloud model developed in their own data centers. There are several solutions on the market, proprietary and open source, offering the possibility to create a private cloud. But the main question is what to do with the systems that are in traditional environment? So this study aims to understand the needs and benefits of using a private cloud, as well as proposing a migration model of their systems that are hosted on a traditional model for a private cloud environment. During the study it will be considered on migration studies with the army business characteristics. At the end of the work a proof of concept is carried out, where the creation of a private cloud environment and the migrating of a system hosted in a traditional virtualized environment for this cloud is employed.
Iterative timing analysis based on nonlinear and interdependent flipflop modelling

In this paper, the authors build a new modelling framework for the timing behaviour of a flipflop by putting the clock-to-q delay into a nonlinear functional relationship with the data/clock alignment of the flipflop. This new framework opens new perspectives into the functioning of a digital circuit by viewing it as a fully interconnected and interdependent system. Consequently, the traditional method for timing analysis is rendered insufficient. An iterative timing analysis method is then developed to solve two related problems. One is to check whether a circuit can work at a given clock period; the other is to determine the minimal clock period of a circuit. Experimental results show that a reduction of the clock period is achieved and its significance is observed especially when process variation is considered.
HLA antigens in familial Guillain-Barré syndrome.

centres who see all new cases and to the hospital if necessary, and traditional hospital-based ones. unusual in that its comparatively I ber of neurologists and hospita offers a fully hospital-based neur ice. We did not study the waiting tin was stated at the beginning of the no patient should wait for more weeks and this was checked at th ment office. This aim was easily ac in fact for most of the year the w was around two weeks. No classi "urgent" or "routine" cases was necessary. (In the past, with long times, we had attempted that classi the basis of the referring doctor's found it unreliable; we had als briefly interview each patient bui impractical). Occasional patients v urgent and seen the same day. Sev per cent of all cases were referre general practitioner. The table shows the main F diagnoses. Sixty six per cent c outpatients had conditions that termed "non-organic" and 34% h problems. The most common diag headaches (27%), anxiety-depress dizziness-faints (11%), epilepsy (5 and other movements (4%), vascu (4%). Five hundred and seventy or (58%) were discharged to the refeL 10 (1%) were admitted to hos (14%) were given a further ap without ordering any tests; 2 received outpatient investigation, ple, 100 had a CT brain scan, 8
The histopathology of grey matter demyelination in multiple sclerosis

Multiple sclerosis (MS) is characterized by focal demyelinating lesions in white matter (WM) and grey matter (GM) of the central nervous system. Results of studies using quantitative magnetic resonance imaging techniques indicate that GM MS pathology has a significant impact on clinical symptoms and disability in MS, and may occur partly independently of WM pathology. Subpial cerebral and cerebellar cortexes are predilection sites for demyelination in MS. Significant neuronal and axonal pathology has been detected in GM MS lesions. The pathology of MS lesions is location‐dependent; there is less pronounced inflammation in GM lesion areas than in WM lesions. The presence and extent of GM lesions has recently been correlated to meningeal inflammation, and cells infected with the Epstein–Barr virus have been detected in meningeal infiltrates, suggesting a role of meningeal inflammation in cortical lesion pathogenesis.
The Use of Sonography for Evaluation of the Integrity and Healing Process of the Tibiofibular Interosseous Membrane in Ankle Fractures

Summary: This study evaluates the value of sonography in the diagnosis of the rupture and healing process of the interosseous membrane in Weber type B and C ankle fractures. In 90 such fractures a rupture of the interosseous membrane was intraoperatively observed in 35 cases (38.8%). All Weber type C fractures showed a rupture of the interosseous membrane, whereas only 23% of the Weber type B fractures were associated with a rupture of the interosseous membrane (p<0.001). In the vast majority of the cases (77%), particularly in all Weber type B fractures (p<0.01), the rupture of the interosseous membrane extended above the proximal fracture line of the fibula. By means of sonography, in the acute posttrauma period a rupture of the interosseous membrane was found in 37.4% of the cases. Thus, in our series the results of sonography and the operative findings coincided in 88.6% of the cases concerning location, type, and extent. Sonography was performed by three unbiased observers, and the results were compared with the intraoperative findings. Thus, the sensitivity of the sonography in the diagnosis of the rupture of the interosseous membrane was 88.8%, the diagnostic value of the method 92.2%, and specificity 94.5%. The sonographic findings of the healing process of the interosseous membrane were in absolute (100%) agreement with the intraoperative observations at the time of removal of the osteosynthesis material. Complete healing occurred within 3-5 months after trauma in 70% of the cases of ruptured interosseous membrane. In the experimental part of our study performed on six cadaveric legs, an association with an equivalent verification of the artificially provoked rupture of the interosseous membrane was found in all cases. Sonography seems to be a valuable noninvasive, nonradiating, inexpensive, repeatable examination for the acute diagnosis of the rupture of the interosseous membrane as well as its subsequent healing.
The developmental fate of the first somite of the chick

The somites of an embryo are among the very earliest morphological units to be formed in the body proper, and are preceded in the chick only by the notochord and the beginning of the head-fold. Furthermore, the somites appear with great regularity (approximately one pair is added with each one and one-half hours of incubation at 37.5"C. from 2 3 4 8 hours), and in definite sequence. These characteristics make the somites particularly useful as a basis f o r morphological stages, and they have been so used for many years (Duval, 1889; Keibel and Abraham, 1900 ; Lillie, '19 ; Hamburger and Hamilton, '51). When the somites are completely formed they extend in linear fashion from a region just posterior to the otocyst as far as the tip of the tail and remain as discrete bbcks of tissue for many hours, and in posterior regions for several days, until the vertebrae begin to form. The somites then break up and contribute to the dermis of the skin, the muscles of the vertebral column, the ribs of the dorsal one-third of the body wall, and the vertebrae. Thus, the somites constitute valuable reference points for locating levels or regions of other adjacent organs or structiires which are non-segmented, irregular in occurrence, or lacking in obvious landmarks. As such, they are much used for descriptive purposes during the first four days of development in the chick.
Hydrogen exchange: The modern legacy of Linderstrøm‐Lang

This discussion, prepared for the Protein Society's symposium honoring the 100th anniversary of Kaj Linderstrøm‐Lang, shows how hydrogen exchange approaches initially conceived and implemented by Lang and his colleagues some 50 years ago are contributing to current progress in structural biology. Examples are chosen from the active protein folding field. Hydrogen exchange methods now make it possible to define the structure of protein folding intermediates in various contexts: as tenuous molten globule forms at equilibrium under destabilizing conditions, in kinetic intermediates that exist for less than one second, and as infinitesimally populated excited state forms under native conditions. More generally, similar methods now find broad application in studies of protein structure, energetics, and interactions. This article considers the rise of these capabilities from their inception at the Carlsberg Labs to their contemporary role as a significant tool of modern structural biology.
RBANS Performance: Influences of Sex and Education

A sample of 278 men and 353 elderly women who resided in the community received the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) as part of a study of health in mature adult Oklahomans. Females attained significantly higher scores on the Immediate and Delayed Memory and the Language Indexes. Males performed better on the Visuospatial/Construction Index, but there was no sex difference on the Attention or Total Indexes. Differences related to sex were modest (2–6 Index points), but combined with the larger effects of education could lead to an adjustment of up to 11 Index points.
Measuring Diversity of a Domain-Specific Crawl

In this work we present various metrics to measure diversity of a domain-speci(cid:28)c crawl. We evaluate these metrics using domain-speci(cid:28)c crawl originated from ODP URLs and (cid:28)nd that these metrics are indeed able to capture diversity. We argue that these metrics can be used for comparing seed sets and crawling strategies with respect to diversity
Cytokine Polymorphisms Play a Role in Susceptibility to Ultraviolet B-Induced Modulation of Immune Responses after Hepatitis B Vaccination1

UVB exposure can alter immune responses in experimental animals and humans. In an earlier human volunteer study, we demonstrated that hepatitis B-specific humoral and cellular immunity after vaccination on average were not significantly affected by UVB exposure. However, it is known that individuals differ in their susceptibility to UVB-induced immunomodulation, and it was hypothesized that polymorphisms in specific cytokines may play a role in this susceptibility. In this respect, we previously demonstrated that immune responses after hepatitis B vaccination are influenced by the minor allelic variant of IL-1β in the general population. For all volunteers, single nucleotide polymorphisms were determined for the following UV response-related cytokines: IL-1 receptor antagonist (+2018), IL-1α (+4845), IL-1β (+3953), TNF-α (−308), and TNF-α (−238). Exposure to UVB significantly suppressed Ab responses to hepatitis B in individuals with the minor variant for the IL-1β polymorphism. Increased minimal erythema dose values (just perceptible), which resulted in higher absolute UVB exposures, were observed in the same individuals. There were no associations observed between UVB-induced immunomodulation and the other cytokine polymorphisms examined. This study indicates that individual susceptibility to UVB radiation needs to be considered when studying the effects of UVB in humans.
Are wages useful in forecasting price inflation

Labor costs constitute a substantial share of business expenses, and it is natural to expect wages to be an important determinant of prices. However, research suggests that wages do not contain much useful information for forecasting price inflation that is not available from other indicators. Therefore, one should not infer too much from recent wage data regarding the future path of inflation.
Detection of Significant Disease Risks Using a Spatial Conditional Autoregressive Model

Summary The conditional autoregressive (CAR) model is widely used to describe the geographical distribution of a specific disease risk in lattice mapping. Successful developments based on frequentist and Bayesian procedures have been extensively applied to obtain two‐stage disease risk predictions at the subregional level. Bayesian procedures are preferred for making inferences, as the posterior standard errors (SE) of the two‐stage prediction account for the variability in the variance component estimates; however, some recent work based on frequentist procedures and the use of bootstrap adjustments for the SE has been undertaken. In this article we investigate the suitability of an analytical adjustment for disease risk inference that provides accurate interval predictions by using the penalized quasilikelihood (PQL) technique to obtain model parameter estimates. The method is a first‐order approximation of the naive SE based on a Taylor expansion and is interpreted as a conditional measure of variability providing conditional calibrated prediction intervals, given the data. We conduct a simulation study to demonstrate how the method can be used to estimate the specific subregion risk by interval. We evaluate the proposed methodology by analyzing the commonly used example data set of lip cancer incidence in the 56 counties of Scotland for the period 1975–1980. This evaluation reveals a close similarity between the solutions provided by the method proposed here and those of its fully Bayesian counterpart.
Fuzzy reliability prediction of rotating machinery product with accelerated testing data

For machinery product experienced several operating conditions, this paper proposes a framework of fuzzy reliability analysis of machinery accelerated testing. Due to the non-stationary of the vibration signals, a Gaussian mixture model (GMM) method is introduced to obtain the degradation index through calculating the overlap between current feature set and the historical baseline set. The features in four domains are extracted. Considered that the uncertainties exit in feature extraction and health assessment, a fuzzy regression model is used to describe the degradation path at each operating condition and compute fuzzy quasi time to failures (q-TTFs). Meanwhile, the relationship between q-TTFs and environmental variables are identified by a linear model, through which the fuzzy reliability analysis can be conducted with the most appropriate lifetime distribution. An industrial application is used to verify the effectiveness of the proposed framework and the results have confirmed a good consistency with the true values.
Human hematopoietic colonies in health and disease.

Introduction Aims of the atlas Background The contribution of cultures in modern hematology Limitations of precursor cell cultures Culture techniques Laboratory equipment and materials Culture media Cell suspensions Optimal number of cells in culture Plating and incubation Reading of cultures Normality and abnormality in culture Normal colonies W CFU-G: Neutrophil granulocyte colonies W CFU-M and CFU-GM: Macrophage and granulocyte-macrophage col onies W CFU-Eo: Eosinophil colonies W BFU-E and CFU-E: Large and small erythroid colonies W CFU-GEMM: Mixed colonies containing neutrophil granulocytes, erythroblasts, macrophages and megakaryocytes W CFU Eo/Ec: Colonies containing eosinophils and erythroblast s W Normal colony numbers, PB:BM ratio and E:M ratio Deviations from normality W Grossly reduced colony growth W Strongly increased colony growth - with normal PB:BM ratio - with high PB:BM ratio W Low erythroid:myeloid (E:M) ratio W Increased CFU-M W Increased CFU-Eo W Increased CFU-GEMM and CFU-Eo/Ec W Deficient hemoglobinization W Erythropoetin-independent BFU-E W Abnormally small colonies W Dendritic cell (DC) - like clusters W Agglutinated red cells and platelets W Scattered macrophages W Non-cellular artefacts W Infectious contaminations W Lack of incubator humidity Contribution of cultures to clinical hematology Differential diagnosis of cytopenic disorders W Guideline from culture observation to diagnosis W Aplastic anemia W Myelodysplastic syndrome W Acute myeloid leukemia W Vitamin B12/folate deficiency W Agranulocytosis W Immune thrombocytopenia W Pure red cell aplasia W Severe Graft-versus-Host Disease Differential diagnosis of hyperproliferative disorders W Neutrophilia, polycythemia, thrombocytosis - Guide from culture observation to diagnosis - Polycythemia vera and essential - thrombocythemia - Idiopathic myelofibrosis - Chronic myeloid leukemia - Gleevec[registered] effects W Eosinophilia - Guide from culture observation to diagnosis - Reactive eosinophilia and hypereosinophilic - syndrome W Monocytosis - Guide from culture observation to diagnosis - Reactive monocytosis and chronic myelo- - monocytic leukemia Subject Index
The cation selectivity and voltage dependence of the light‐activated potassium conductance in scallop distal photoreceptor.

Light‐dependent voltage and current responses were measured from the distal hyperpolarizing photoreceptors of the scallop (Pecten irradians) retina. In normal external solution, the hyperpolarizing receptor potential was caused by a light‐dependent K+ outward current. The magnitude of the hyperpolarizing receptor potential and the light‐dependent outward current, measured at the resting potential, was graded with light intensity. In normal external solution, during prolonged illumination the light‐dependent K+ outward current was characterized by an early peak and a subsequent plateau. Current responses to brief light flashes were reduced progressively during background illumination. In the absence of external Na+ ions, the reversal potential for the receptor potential changed 58 mV per 10‐fold change in the extracellular K+ concentration. The estimated internal K+ concentration was 385 mM. The hyperpolarizing receptor potential produced by prolonged bright illumination consists of an early peak which decays to a plateau. This decay was determined by a decrease in the light‐dependent K+ conductance during maintained illumination. The light‐dependent conductance pathway passed outward currents better than inward K+ currents. The light‐dependent K+ conductance was estimated to increase e‐fold per 23‐34 mV depolarization at the peak and during the plateau of the light response. The light‐dependent conductance pathway was highly selective for K+ ions. The selectivity sequence for monovalent cations was T1+, K+ greater than Rb+ greater than NH4 greater than Cs+, Li+, Na+. External caesium and tetraethylammonium blocked inward but not outward K+ currents through the light‐dependent K+ conductance pathway. The data suggest that K+ ions move through an aqueous pore which is controlled by light.
Prolonged Colonic Manometry in Children With Defecatory Disorders

Objectives: Colonic manometry is a test used in the evaluation of children with defecation disorders unresponsive to conventional treatment. The most commonly reported protocol in pediatrics consists of a study that lasts approximately 4 hours. Given the wide physiological variations in colonic motility throughout the day, longer observation may detect clinically relevant information. The aim of the present study was to compare prolonged colonic manometry studies in children referred for colonic manometry with the more traditional short water-perfused technology. Methods: Colonic manometry studies of 19 children (8 boys, mean age 9.4 ± 0.9, range 3.9–16.3) with severe defecation disorders were analyzed. First, a “standard test” was performed with at least 1-hour fasting, 1-hour postprandial, and 1-hour postbisacodyl provocation recording. Afterwards, recordings continued until the next day. Results: In 2 of the 19 children, prolonged recording gave us extra information. In 1 patient with functional nonretentive fecal incontinence who demonstrated no abnormalities in the short recording, 2 long clusters of high-amplitude contractions were noted in the prolonged study, possibly contributing to the fecal incontinence. In another patient evaluated after failing use of antegrade enemas through a cecostomy, short recordings showed colonic activity only in the most proximal part of the colon, whereas the prolonged study showed normal motility over a larger portion of the colon. Conclusions: Prolonged colonic measurement provides more information regarding colonic motor function and allows detection of motor events missed by the standard shorter manometry study.
Invasive carcinomas and fibroadenomas of the breast: comparison of microvessel distributions--implications for imaging modalities.

PURPOSE To compare spatial patterns of blood vessels between invasive breast carcinomas and fibroadenomas to improve the diagnostic specificity of noninvasive vascular magnetic resonance imaging and color Doppler ultrasound. MATERIALS AND METHODS Nineteen invasive ductal carcinomas and 20 fibroadenomas from 39 patients were stained for factor VIII-related antigen. Vessels smaller than 40 microns were counted in x200 fields defined in peripheral and central areas of the tumor and in normal tissue adjacent to fibroadenomas. Significant differences in vessel density were determined with Student t tests and one-way analyses of variance. Distributions of vessels 40 microns or larger were qualitatively evaluated. RESULTS There were 9-105 vessels (mean, 31.4 vessels) smaller than 40 microns per x200 peripheral and 4-57 vessels (mean, 20.1 vessels) smaller than 40 microns per x200 central carcinoma field. There was no significant difference in vessel density between the two groups. Peripheral microvessel density was significantly higher (P < .01) than central microvessel density in 15 (79%) of the 19 carcinomas and in three (16%) of 19 fibroadenomas. (A Student t test could not be performed in one case of fibroadenoma; size permitted only one countable field according to the authors' criteria.) The 18 cases with normal tissue had 21-229 vessels (mean, 80.5 vessels) per field; in 16 (89%) of the 18 cases, these vessel counts were significantly higher (P < .01) than those in the fibroadenoma cases. Vessels 40 microns or larger were found mainly in the periphery of carcinomas and were more uniformly distributed in fibroadenomas. CONCLUSION Evaluation of the spatial distribution of vessels and the ability to resolve vessel sizes may add valuable information to the imaging-based diagnostic work-up of indeterminate solid breast lesions.