Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of quetiapine in protection of neurodegeneration after traumatic brain injury

Objective Schizophrenia is a chronic psychotic disorder in which patients experience positive and negative symptoms for over six months. Schizophrenia is associated with early mortality, with 40% of this excess mortality due to suicide. This is a case of patient with schizophrenia who was treated with quetiapine after suffering a traumatic brain injury and recovered enough to be discharged to a rehabilitation unit. This case illustrates the neuroprotective effects of quetiapine in treating neurologic deficits in a patient who recently suffered a traumatic brain injury. Method This is a case report of a patient with schizophrenia treated in the hospital setting. He was placed on quetiapine after suffering a traumatic brain injury due to a suicide attempt in which he shot himself with a nail gun. Results The patient initially presented with neurologic deficits suggestive of traumatic brain injury (inattention, memory loss, muscle weakness) and psychosis from schizophrenia. He was treated with quetiapine and recovered enough to be discharged to a rehabilitation unit. Conclusion Quetiapine, a second-generation antipsychotic, has been shown to significantly decrease blood–brain barrier hyperpermeability by preserving tight junction integrity in small animal models. This anti-inflammatory effect may also help to preserve neurogenesis in patients with traumatic brain injury, as shown in this case. This case may help elucidate the nature of quetiapine’s neuroprotective effects in patients who have suffered traumatic brain injury and also highlights the need to further investigate other atypical antipsychotics and their potential neuroprotective role in treating traumatic brain injury.
Simulation of the nanofiltration of pulping black liquor by dynamic blade cross-flow with membrane

This paper investigated the filtration of black liquor with blade cross-flow by membrane. The lignin content in black liquid filtered by the nanofiltration membrane (NP010) is high under the transmembrane pressure of 0.5 bar, 1 bar, 1.5 bar, and 2 bar at 300 rpm and 800 rpm. In this regard, the tangential velocity on the nanofiltration membrane surface and the pressure variation on the blade in the process of filtration are simulated and analyzed with Fluent software. The tangential flow velocity on the nanofiltration membrane surface and the dynamic pressure on the blade, as well as the law of change under different rotation speed and transmembrane pressure are obtained. The comparison between experimental and simulated results have validated the numerical model of the filtration of black liquid by the blade dynamic cross-flow. According to the experimental and simulated results, the optimized filtration conditions are obtained when the blade dynamic cross-flow uses 1 kDa nanofiltration membrane to filter black liquor.
Performance analysis and extended dissipative controller design for Itô stochastic-delayed IT2 fuzzy models

This paper deals with the problems of stochastic asymptotic stability analysis and extended dissipativity as well as controller design for Itô stochastic-delayed IT2 fuzzy systems by using line integral type Lyapunov–Krasovskii functional (LKF). A good estimate of the upper bound for the line integral type LKF is achieved, based on which, the conditions of stochastic asymptotic stability and extended dissipativity are derived. A comparison has been drawn between the conditions derived by line integral type LKF and the ones by the quadratic LKF in a numerical example, to indicate that the conditions by line integral approach are more general than the ones via quadratic method. Meanwhile, these conditions are of nonlinear form with respect to some matrix variables which makes the determination of the extended dissipative controller difficult. Inspired by cone complementarity linearisation algorithm and a novel matrix decoupling method, the state feedback controller is developed by transforming the nonlinear matrix inequalities into a quadratic optimisation problem with linear matrix inequality constraints. Finally, two examples are given to show the validity of our proposed approach.
Global hierarchical collapse in molecular clouds. Towards a comprehensive scenario

We present a unified description of the scenario of global hierarchical collapse (GHC). GHC constitutes a flow regime of (non-homologous) collapses within collapses, in which all scales accrete from their parent structures, and small, dense regions begin to contract at later times, but on shorter time-scales than large, diffuse ones. The different time-scales allow for most of the clouds’ mass to be dispersed by the feedback from the first massive stars, maintaining the cloud-scale star formation rate low. Molecular clouds (MCs), clumps, and cores are not in equilibrium, but rather are either undergoing contraction or dispersal. The main features of GHC are as follows: (1) The gravitational contraction is initially very slow, and begins when the cloud still consists of mostly atomic gas. (2) Star-forming MCs are in an essentially pressureless regime, causing filamentary accretion flows from the cloud to the core scale to arise spontaneously. (3) Accreting objects have longer lifetimes than their own free-fall time, due to the continuous replenishment of material. (4) The clouds’ total mass and its molecular and dense mass fractions increase over time. (5) The clouds’ masses stop growing when feedback becomes important. (6) The first stars appear several megayears after global contraction began, and are of low mass; massive stars appear a few megayears later, in massive hubs. (7) The minimum fragment mass may well extend into the brown-dwarf regime. (8) Bondi–Hoyle–Lyttleton-like accretion occurs at both the protostellar and the core scales, accounting for an IMF with slope dN/dM ∝ M−2. (9) The extreme anisotropy of the filamentary network explains the difficulty in detecting large-scale infall signatures. (10) The balance between inertial and gravitationally driven motions in clumps evolves during the contraction, explaining the approach to apparent virial equilibrium, from supervirial states in low-column density clumps and from subvirial states in dense cores. (11) Prestellar cores adopt Bonnor–Ebert-like profiles, but are contracting ever since when they may appear to be unbound. (12) Stellar clusters develop radial age and mass segregation gradients. We also discuss the incompatibility between supersonic turbulence and the observed scalings in the molecular hierarchy. Since gravitationally formed filaments do not develop shocks at their axes, we suggest that a diagnostic for the GHC scenario should be the absence of strong shocks in them. Finally, we critically discuss some recent objections to the GHC mechanism.
High‐intensity end‐of‐life care among children, adolescents, and young adults with cancer who die in the hospital: A population‐based study from the French national hospital database

Efforts to improve the quality of end‐of‐life (EOL) care depend on better knowledge of the care that children, adolescents, and young adults with cancer receive, including high‐intensity EOL (HI‐EOL) care. The objective was to assess the rates of HI‐EOL care in this population and to determine patient‐ and hospital‐related predictors of HI‐EOL from the French national hospital database.
Rapid Detection of Brucella spp. and Elimination of Carryover Using Multiple Cross Displacement Amplification Coupled With Nanoparticles-Based Lateral Flow Biosensor

Brucella spp.is capable of causing disease in a range of animal hosts, and human brucellosis is regarded as a life-threating disease. A novel isothermal amplification technique, termed multiple cross displacement amplification (MCDA), was employed for detecting all Brucella species strains. Brucella-MCDA targets the Bscp31 gene (Brucella species-specific gene) to specifically design a set of 10 primers. The Brucella-MCDA can be coupled with nanoparticles-based lateral flow biosensor (LFB) for highly specific, simple, rapid, and visual detection of Brucella-specific amplicons. Using the protocol, a MCDA amplification followed by 2 min LFB resulted in visualization of DNA products trapped at the LFB test line. Various species of Gram-positive and Gram-negative strains are applied for optimizing and evaluating the target assay. Optimal MCDA condition is found to be 63°C for 40 min, with detection limits at 10 fg of templates in the pure cultures. The specificity of MCDA-LFB technique is of 100%, and no cross-reactions to non-Brucella strains are observed according to the specificity examination. Furthermore, dUTP and AUDG enzyme are added into the MCDA reaction mixtures, which are used for removing false-positive amplification generating from carryover contamination. Thus, 20 min for rapid template extraction followed by AUDG digestion (5 min), MCDA (40 min) combined with LFB detection (2 min) resulted in a total assay time of ~70 min. In sum, Brucella-MCDA-LFB technique is a rapid, simple, reliable, and sensitive method to detect all Brucella species strains, and can be used as potential screening tool for Brucella strains in various laboratories.
Characterizing Trends in Human Papillomavirus Vaccine Discourse on Reddit (2007-2015): An Observational Study

Background Despite the introduction of the human papillomavirus (HPV) vaccination as a preventive measure in 2006 for cervical and other cancers, uptake rates remain suboptimal, resulting in preventable cancer mortality. Social media, widely used for information seeking, can influence users’ knowledge and attitudes regarding HPV vaccination. Little is known regarding attitudes related to HPV vaccination on Reddit (a popular news aggregation site and online community), particularly related to cancer risk and sexual activity. Examining HPV vaccine–related messages on Reddit may provide insight into how HPV discussions are characterized on forums online and influence decision making related to vaccination. Objective We observed how the HPV vaccine is characterized on Reddit over time and by user gender. Specifically, this study aimed to determine (1) if Reddit messages are more related to cancer risks or sexual behavior and (2) what other HPV vaccine–related discussion topics appear on Reddit. Methods We gathered all public Reddit comments from January 2007 to September 2015. We manually annotated 400 messages to generate keywords and identify salient themes. We then measured the similarity between each comment and lists of keywords associated with sexual behavior and cancer risk using Latent Semantic Analysis (LSA). Next, we used Latent Dirichlet Allocation (LDA) to characterize remaining topics within the Reddit data. Results We analyzed 22,729 messages containing the strings hpv or human papillomavirus and vaccin. LSA findings show that HPV vaccine discussions are significantly more related to cancer compared with sexual behavior from 2008 to 2015 (P<.001). We did not find a significant difference between genders in discussions of cancer and sexual activity (P>.05). LDA analyses demonstrated that although topics related to cancer risk and sexual activity were both frequently discussed (16.1% and 14.5% of word tokens, respectively), the majority of online discussions featured other topics. The most frequently discussed topic was politics associated with the vaccine (17.2%). Other topics included HPV disease and/or immunity (13.5%), the HPV vaccine schedule (11.5%), HPV vaccine side effects (9.7%), hyperlinks to outside sources (9.1%), and the risks and benefit of HPV vaccination (8.5%). Conclusions Reddit discourse on HPV vaccine encompasses a broad range of topics among men and women, with HPV political debates and cancer risk making up the plurality of the discussion. Our findings demonstrated that women and men both discussed HPV, highlighting that Reddit users do not perceive HPV as an issue that only pertains to women. Given the increasing use of social media as a source of health information, these results can inform the development of targeted online health communication strategies to promote HPV vaccination to young adult users of Reddit. Analyzing online discussions on Reddit can inform health communication efforts by identifying relevant, important HPV-related topics among online communities.
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy

Abstract Aims Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. Methods and results Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interquartile range 2.44–9.33) years of follow-up, 146 (27.7%) experienced sustained VA, defined as SCD, aborted SCD, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator (ICD) therapy. A prediction model estimating annual VA risk was developed using Cox regression with internal validation. Eight potential predictors were pre-specified: age, sex, cardiac syncope in the prior 6 months, non-sustained ventricular tachycardia, number of premature ventricular complexes in 24 h, number of leads with T-wave inversion, and right and left ventricular ejection fractions (LVEFs). All except LVEF were retained in the final model. The model accurately distinguished patients with and without events, with an optimism-corrected C-index of 0.77 [95% confidence interval (CI) 0.73–0.81] and minimal over-optimism [calibration slope of 0.93 (95% CI 0.92–0.95)]. By decision curve analysis, the clinical benefit of the model was superior to a current consensus-based ICD placement algorithm with a 20.3% reduction of ICD placements with the same proportion of protected patients (P < 0.001). Conclusion Using the largest cohort of patients with ARVC and no prior VA, a prediction model using readily available clinical parameters was devised to estimate VA risk and guide decisions regarding primary prevention ICDs (www.arvcrisk.com).
Plant-herbivore coevolution and plant speciation.

More than five decades ago, Ehrlich and Raven proposed a revolutionary idea-that the evolution of novel plant defense could spur adaptive radiation in plants. Despite motivating much work on plant-herbivore coevolution and defense theory, Ehrlich and Raven never proposed a mechanism for their "escape and radiate" model. Recent intriguing mechanisms proposed by Marquis et al. include sympatric divergence, pleiotropic effects of plant defense traits on reproductive isolation, and strong postzygotic isolation, but these may not be general features of herbivore-mediated speciation. An alternate view is that herbivores may impose strong divergent selection on defenses in allopatric plant populations, with plant-herbivore coevolution driving local adaptation resulting in plant speciation. Building on these ideas, we propose three scenarios that consider the role of herbivores in plant speciation. These include (1) vicariance, subsequent coevolution within populations and adaptive divergence between geographically isolated populations, (2) colonization of a new habitat lacking effective herbivores followed by loss of defense and then re-evolution and coevolution of defense in response to novel herbivores, and (3) evolution of a new defense followed by range expansion, vicariance, and coevolution. We discuss the general role of coevolution in plant speciation and consider outstanding issues related to understanding: (1) the mechanisms behind cospeciation of plants and insects, (2) geographic variation in defense phenotypes, (3) how defensive traits and geography map on plant phylogenies, and (4) the role of herbivores in driving character displacement in defense phenotypes of related species in sympatry.
Population genetic structure of Marbled Rockfish, Sebastiscusmarmoratus (Cuvier, 1829), in the northwestern Pacific Ocean

Abstract Sebastiscusmarmoratus is an ovoviviparous fish widely distributed in the northwestern Pacific. To examine the gene flow and test larval dispersal strategy of S.marmoratus in Chinese and Japanese coastal waters, 421 specimens were collected from 22 localities across its natural distribution. A 458 base-pair fragment of the mitochondrial DNA (mtDNA) control region was sequenced to examine genetic diversity and population structure. One-hundred-six variable sites defined 166 haplotypes. The populations of S.marmoratus showed high haplotype diversity with a range from 0.8587 to 0.9996, indicating a high level of intrapopulation genetic diversity. Low non-significant genetic differentiation was estimated among populations except those of Hyogo, Behai, and Niiigata, which showed significant genetic differences from the other populations. The demographic history examined by neutrality tests, mismatch distribution analysis, and Bayesian skyline analysis suggested a sudden population expansion dating to the late Pleistocene. Recent population expansion in the last glacial period, wide dispersal of larvae by coastal currents, and the homogeneity of the environment may have important influences on the population genetic pattern. Knowledge of genetic diversity and genetic structure will be crucial to establish appropriate fishery management of S.marmoratus.
STUDY ON DIVERSITY OF AQUATIC INSECTS IN RAMAUA RESERVOIR OF GWALIOR DISTRICT (M. P.)

Aquatic insects are those which live a part of their life cycle in water. In addition to their significant ecosystem function aquatic insects are also a primary source of food for fishes and amphibians. Inland wetlands of India serve as the habitat for more than 500 species of aquatic insects which are mainly from Ephimeroptera, Odonta and Trichoptera. The study was conducted during early hours of the day from August, 2019 to November 2019. Three sites were selected for the study i.e. vegetation site, agricultural site and disturbed vegetation site. The checklist of recorded aquatic insects is shown with their taxa, order, family and scientific name and common name. Total 24 species of aquatic insects were found in three different sites. The study of population of insects in different sites revealed the fact that the population of aquatic insects was governed by abiotic and biotic factors.
Identification of Shared Genes Between Ischemic Stroke and Parkinson's Disease Using Genome-Wide Association Studies

Ischemic stroke (IS) and Parkinson's disease (PD) are two neurological diseases that often strike individuals of advanced age. Although thought of as a disease of old age, PD can occur in younger patients. In many of these cases, genetic mutations underlie the disease. As with PD, stroke can also have a genetic component. Although many of the risk factors for IS are considered to be modifiable, a significant portion is not, suggesting that some of stroke risk factors may have a genetic origin. Large-scale genome-wide association studies (GWAS) have identified several IS and PD gene variants recently. Converging epidemiologic and pathological evidence suggests that IS and PD may be linked. However, it is still unclear whether these two conditions share a common mechanism. Here, we sought to determine the genetic mechanism underlying the possible association between IS and PD. We conducted a multi-step systemic analysis comprising (1) identification of IS and PD variants validated by known GWAS, (2) two separate gene-based tests using Versatile Gene-based Association Study 2 (VEGAS2) and PLINK, (3) a transcriptome-wide association study (TWAS), and (4) analyses of gene expression using an online tool in Gene Expression Omnibus. Our investigation revealed that IS and PD have in common five shared genes: GPX7, LBH, ZCCHC10, DENND2A, and NUDT14, which pass gene-based tests. Functionally, these genes are expressed differentially in IS and PD patients compared to neurologically healthy control subjects. This genetic overlap may provide clues on how IS and PD are linked mechanistically. This new genetic insight into these two diseases may be very valuable for narrowing the focus of future studies on the genetic basis of IS and PD and for developing novel therapies.
Effects of elevated salinity on Cuban treefrog Osteopilus septontrionalis aldosterone levels, growth, and development

ABSTRACT Amphibians are increasingly challenged with salinization due to factors such as elevated sea level associated with climate change, the use of road salts, and lowering of water tables. Aldosterone is a steroid hormone that is produced by the adrenal cortex and is involved in osmotic regulation and may play an important role in amphibian acclimation to elevated salinity. We studied the effects of salinity on growth, development, and aldosterone levels in Cuban treefrog (Osteopilus septentrionalis) tadpoles. Gosner stage, growth rates, and aldosterone levels were determined for tadpoles among three salinity treatments (1.0, 2.5, and 3.5 ppt) over a six-week period. It appears that Cuban treefrog tadpoles have the ability to respond to high salt levels with decreased aldosterone secretion; however, in order to survive high salt concentrations, trade-offs in growth and development must occur to regulate osmotic functions.
A 5′-to-3′ strand exchange polarity is intrinsic to RecA nucleoprotein filaments in the absence of ATP hydrolysis

Abstract RecA is essential to recombinational DNA repair in which RecA filaments mediate the homologous DNA pairing and strand exchange. Both RecA filament assembly and the subsequent DNA strand exchange are directional. Here, we demonstrate that the polarity of DNA strand exchange is embedded within RecA filaments even in the absence of ATP hydrolysis, at least over short DNA segments. Using single-molecule tethered particle motion, we show that successful strand exchange in the presence of ATP proceeds with a 5′-to-3′ polarity, as demonstrated previously. RecA filaments prepared with ATPγS also exhibit a 5′-to-3′ progress of strand exchange, suggesting that the polarity is not determined by RecA disassembly and/or ATP hydrolysis. RecAΔC17 mutants, lacking a C-terminal autoregulatory flap, also promote strand exchange in a 5′-to-3′ polarity in ATPγS, a polarity that is largely lost with this RecA variant when ATP is hydrolyzed. We propose that there is an inherent strand exchange polarity mediated by the structure of the RecA filament groove, associated by conformation changes propagated in a polar manner as DNA is progressively exchanged. ATP hydrolysis is coupled to polar strand exchange over longer distances, and its contribution to the polarity requires an intact RecA C-terminus.