Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance investigation of Extended Kalman Filter combined with carrier phase recovery for adaptive nonlinear phase noise mitigation

Performance of Extended Kalman Filter combined with the Viterbi-Viterbi phase estimator (VVPE-EKF) for adaptive nonlinear phase noise mitigation is studied. The VVPE-EKF achieves 1.4 dB, 1.6 dB and 2.3 dB nonlinear system tolerance promotion at BER=1e-3 for linewidth of 100 kHz, 1 MHz and 2 MHz compared to the least mean square combined with VVPE (VVPE-LMS). VVPE-EKF become convergent much faster than VVPE-LMS.
Ring Polymers: Threadings, Knot Electrophoresis and Topological Glasses

Elucidating the physics of a concentrated suspension of ring polymers, or of an ensemble of ring polymers in a complex environment, is an important outstanding question in polymer physics. Many of the characteristic features of these systems arise due to topological interactions between polymers, or between the polymers and the environment, and it is often challenging to describe this quantitatively. Here we review recent research which suggests that a key role is played by inter-ring threadings (or penetrations), which become more abundant as the ring size increases. As we discuss, the physical consequences of such threadings are far-reaching: for instance, they lead to a topologically-driven glassy behaviour of ring polymer melts under pinning perturbations, while they can also account for the shape of experimentally observed patterns in two-dimensional gel electrophoresis of DNA knots.
Baseline inhibin B and anti-Mullerian hormone measurements for diagnosis of hypogonadotropic hypogonadism (HH) in boys with delayed puberty.

CONTEXT The diagnosis of isolated hypogonadotropic hypogonadism (IHH) in boys with delayed puberty is challenging, as may be the diagnosis of hypogonadotropic hypogonadism (HH) in boys with combined pituitary hormone deficiency (CPHD). Yet, the therapeutic choices for puberty induction depend on accurate diagnosis and may influence future fertility. OBJECTIVE The aim was to assess the utility of baseline inhibin B (INHB) and anti-Mullerian hormone (AMH) measurements to discriminate HH from constitutional delay of puberty (CDP). Both hormones are produced by Sertoli cells upon FSH stimulation. Moreover, prepubertal AMH levels are high as a reflection of Sertoli cell integrity. PATIENTS We studied 82 boys aged 14 to 18 yr with pubertal delay: 16 had IHH, 15 congenital HH within CPHD, and 51 CDP, as confirmed by follow-up. Subjects were genital stage 1 (testis volume<3 ml; 9 IHH, 7 CPHD, and 23 CDP) or early stage 2 (testis volume, 3-6 ml; 7 IHH, 8 CPHD, and 28 CDP). RESULTS Age and testis volume were similar in the three groups. Compared with CDP subjects, IHH and CPHD subjects had lower INHB, testosterone, FSH, and LH concentrations (P<0.05), whereas AMH concentration was lower only in IHH and CPHD subjects with genital stage 1, likely reflecting a smaller pool of Sertoli cells in profound HH. In IHH and CPHD boys with genital stage 1, sensitivity and specificity were 100% for INHB concentration of 35 pg/ml or less. In IHH and CPHD boys with genital stage 2, sensitivities were 86 and 80%, whereas specificities were 92% and 88%, respectively, for an INHB concentration of 65 pg/ml or less. The performance of testosterone, AMH, FSH, and LH measurements was lower. No combination or ratio of hormones performed better than INHB alone. CONCLUSION Discrimination of HH from CDP with baseline INHB measurement was excellent in subjects with genital stage 1 and fair in subjects with genital stage 2.
MDM2 SNP 309G Allele Is Associated With Younger Age at Surgery in Chronic Pancreatitis Patients

To the Editor: R ecently, we have shown that a welldescribed single nucleotide polymorphism in the MDM2 gene (MDM2 SNP 309) is associated with allelic differences in the age of pancreatic ductal adenocarcinoma (PDAC) onset and prognosis. Functional and molecular data suggest that these associations are the result of upregulation of gene expression of MDM2, a key negative regulator of the p53 protein, by the G allele of MDM2 SNP 309. This up-regulation of gene expression results in higher MDM2 protein levels, an attenuation of the p53 stress response and therefore increased tumor risk and progression. One of the main risk factors for the development of PDAC is chronic pancreatitis (CP). In this study, we aimed to assess whether those SNPs associate with the course of CP. Fifty-one patients were operated on for CP and included into the investigation on the basis of their written consent from
Detection and graphical visualization of relationships between entities in Wikipedia

In this paper, we describe an approach to uncover and visualize relationships along entities in Wikipedia-pages. We define different distance metrics between Wikipedia articles, based on the link structure. A prototype was implemented, which allows the specification of arbitrary Wikipedia entities with the help of an auto-completion mechanism and the detection of paths with different characteristics between them. The resulting paths between the entities are visualized graphically.
Color naming, matching, and recognition by preschoolers.

24 children, between the ages of 3 years 9 months and 5 years 1 month were given a perceptual task (color matching), a memory task (color recognition), and a labeling task (color naming). The relation between the name given by an individual child to a color and the way the color was manipulated by him in the other tasks was demonstrated in that nearly all the matching and recognition responses, even when incorrect, were colors to which the child gave the same name as to the stimulus color. Contrary to expectation, this tendency was stronger on the matching task; all subjects showed the tendency on the matching task, while only those children who spontaneously named the colors as they were presented showed this effect on the recognition task. It is proposed that perception of colors leads to a kind of covert naming. This proposal is considered in terms of mediation, and it is argued that the nonnamers in the recognition task do not suffer from production deficiency but rather from lack of memory for the mediator produced.
[Culicidae mosquito abundance in a preserved metropolitan area and its epidemiological implications].

OBJECTIVE To study the adult Culicidae fauna in a preserved area in urban outskirts for describing species of public health concern. METHODS This study was developed in the Tiet Ecological Park located in the outskirt of the city of S o Paulo, Brazil. Monthly collections were undertaken in three habitats at different times using electric aspirators and CDC and Shannon traps from August 1996 to March 1998. Data analysis was based on estimates of frequencies and abundance. RESULTS Twenty-five species or generic groups were identified among 53,496 specimens collected. Ochlerotatus scapularis, Culex quinquefasciatus, and Culex declarator were the most frequent and abundant species. CONCLUSIONS The most frequent and abundant species have been implicated in disease transmission to man in other regions. Attention must be given to these Culicidae since the study area is located near to an urban center, which could amplify the conditions for spreading vector diseases.
Bounded analytic functions

The objective of this paper is to give an alternative derivation of results on bounded analytic functions recently obtained by Ahlfors [1] and Garabedian [2]. 1 While it is admitted that the main idea to be used is more in the nature of a lucky guess than of a method, it will be found that the gain in brevity and simplicity of the argument is considerable. As a by-product, we shall also obtain a number of hitherto unknown identities between various domain functions. The basic problem treated in the above-mentioned papers is the following generalization of the classical Schwarz lemma: Given a finite schlicht domain D of connectivity n (n> 1) in the complex zplane and a point r in D, to find a function F(z) with the following properties: (a) F(z) belongs to the family B of analytic functions f(z) which are single-valued and regular in D and satisfy there If(z) I _ 1; (b) I F'(r) I > lf'(r) J, where f(z) is any function in B. Evidently, it is sufficient to solve this problem for any domain D' which is conformally equivalent to D. In particular, we may therefore assume, without restricting the generality of what follows, that D is bounded by analytic curves. It was shown by Ahlfors that F(z) yields a (1, n) conformal mapping of D onto the interior of the unit circle and that n-I of the n zeros of F(z) coincide with the zeros of a single-valued function h(z) which is regular in D with the exception of a simple pole at z = and satisfies -'ih(z)dz>O on the boundary r of D; the nth zero of F(z) is located at zx=. It was subsequently noticed by Garabedian that the function h(z) can be written in the form h(z) = F(z)q(z) where q(z) (Z )-2 is regular in D and that the extremal property of F(z) can be deduced in a very elegant manner from the resulting inequality
Probabilistic Anomaly Detection in Energy Time Series Data

This paper introduces probabilistic approaches for anomaly detection, specifically in natural gas time series data. In the energy field, there are various types of anomalies, each induced by diverse causes and sources. The causes of a set of anomalies are examined and categorized. A Bayesian maximum likelihood classifier learns the temporal structure of known anomalies. Given a previously unseen time series data, the system detects anomalies using a linear regression model with weather inputs. Then the anomalies are tested for false positives and classified using the Bayesian classifier. The system also can identify anomalies of unknown origin. Thus, the likelihood of a data point being anomalous is given for anomalies of both known and unknown origins. The anomaly detection algorithms are tested on a reported natural gas consumption data set.
Adipocyte-Derived Plasma Protein Adiponectin Acts as a Platelet-Derived Growth Factor-BB–Binding Protein and Regulates Growth Factor–Induced Common Postreceptor Signal in Vascular Smooth Muscle Cell

Background—Vascular smooth muscle cell proliferation plays an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipocyte-specific plasma protein, accumulated in the human injured artery and suppressed endothelial inflammatory response as well as macrophage-to-foam cell transformation. The present study investigated the effects of adiponectin on proliferation and migration of human aortic smooth muscle cells (HASMCs). Methods and Results—HASMC proliferation was estimated by [3H] thymidine uptake and cell number. Cell migration assay was performed using a Boyden chamber. Physiological concentrations of adiponectin significantly suppressed both proliferation and migration of HASMCs stimulated with platelet-derived growth factor (PDGF)-BB. Adiponectin specifically bound to 125I-PDGF-BB and significantly inhibited the association of 125I-PDGF-BB with HASMCs, but no effects were observed on the binding of 125I-PDGF-AA or 125I-heparin–binding epidermal growth factor (EGF)–like growth factor (HB-EGF) to HASMCs. Adiponectin strongly and dose-dependently suppressed PDGF-BB–induced p42/44 extracellular signal–related kinase (ERK) phosphorylation and PDGF &bgr;-receptor autophosphorylation analyzed by immunoblot. Adiponectin also reduced PDGF-AA–stimulated or HB-EGF–stimulated ERK phosphorylation in a dose-dependent manner without affecting autophosphorylation of PDGF &agr;-receptor or EGF receptor. Conclusions—The adipocyte-derived plasma protein adiponectin strongly suppressed HASMC proliferation and migration through direct binding with PDGF-BB and generally inhibited growth factor–stimulated ERK signal in HASMCs, suggesting that adiponectin acts as a modulator for vascular remodeling.
Diabetes mellitus abrogates the cardioprotection of sufentanil against ischaemia/reperfusion injury by altering glycogen synthase kinase‐3β

Sufentanil is widely used in clinical anaesthesia because of its protective effects against ischaemia/reperfusion injury. Diabetes mellitus elevates the activity of glycogen synthase kinase‐3β (GSK‐3β), thereby increasing the permeability of mitochondrial transition pore. This study investigated the role of GSK‐3β in ameliorating the cardioprotective effect of sufentanil post‐conditioning in diabetic rats.
Stress-recovery correlates of cardiac vagal modulation in women recruit undergoing basic combat police training

Stress disturbs autonomic system balance and is detrimental to the overall quality of life. The objective measurement of stress is challenging as individuals level of perception vary. The indirect assessment of vagal modulation of the heart is a commonly used method to objectively measure perceived stress. The initial recovery characteristics of heart rate after physical exertion reflect the vagal influence of autonomous system on the heart. Timely monitoring of stress symptoms in people involved in maintaining law and order is essential especially when an increase in performance demand is put on them. In this work, women police recruits of Kerala are studied during their tenure in training camp on perceived stress. The objective is to find out whether heart rate recovery has the potential to become a valuable tool to monitor perceived stress in a typical stressful training environment. Stress assessed subjectively via REST-Q 76 questionnaire is analyzed for its association in moderating initial recovery of heart rate after a bout of short duration submaximal physical exertion. In our analysis, higher perceived stress is associated with lower heart rate recovery. 30 and 60s recovery level and slope of recovery curves correlated with many subscales of stress and recovery. Also differences between the magnitudes of correlations as presented by the Steiger's Z value at two different occasions were found to be not significant. Results promise, fast, reliable and economical objective measure of perceived stress which can be applied in field settings. Results also suggest poor reliability of heart rate recovery signals from submaximal exercise in assessing physical fitness may in part be due to its connection with stress and recovery of individuals. This has broad implications for identifying candidates at risk of overtraining, burnout and future adversities.
Phytochemicals – A Global Perspective of Their Role in Nutrition and Health 468 Category Subclass Structure Common Flavonoid Food Examples Phenolic acids Hydroxycinnamic acids Caffeic acid coffee beans

Osteoporosis is a skeletal disease characterized by bone loss and structural deterioration of the bone tissue, leading to an increase in bone fragility and susceptibility to fractures, most frequently in the hip, wrist and spine (Sendur et al., 2009). Bone loss is associated with such factors as age, menopause in women, smoking, alcohol excess, calcium and vitamin D deficiency, low weight and muscle mass, anticonvulsant and corticosteroid use as well as certain co-morbid conditions such as rheumatoid arthritis (Javaid et al., 2008). Worldwide, it has been estimated that fractures caused by osteoporosis account for approximately one in three among women and approximately one in five among men over the age of 50. Although the mechanisms underlying osteoporosis are not fully understood, there is evidence suggesting that oxidative stress caused by reactive oxygen species (ROS) is associated with its pathogenesis (Sahnoun et al., 1997; Basu et al., 2001; Rao et al., 2007).
Suggested Protocol for a One-Year Trial of Therapeutic Plasma Exchange for Treating Patients with Limited Systemic Sclerosis

The purpose of this document is to provide background information for physicians and patients who have reviewed the research literature on the use of therapeutic plasma exchange (TPE) to treat systemic sclerosis (SSc) and made the determination that this may be an appropriate treatment option. While this is not intended to be a formal research proposal, it is hoped that by following a standardized protocol for administering TPE, as well as including a basic set of objective measures during the trial of TPE, we may be able to glean important information that can be used as the basis for future well-designed clinical trials of TPE for treating patients with SSc.
JAK2V617F/TET2 mutations: does the order matter?

According to the World Health Organization classification, myeloproliferative neoplasms (MPN) include chronic myelogenous leukemia, also known as BCR-ABL1 –positive MPN, classic BCR-ABL1 -negative MPN including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF
Membrane-Delimited Phosphorylation Enables the Activation of the Outward-Rectifying K Channels in Motor Cell Protoplasts of Samanea saman

Outward-rectifying K channels activated by membrane depolarization (Kout or KD channels) control K+ efflux from plant cells. To find out to what extent phosphorylation is required for the activity of these channels, the patch-clamp method was applied to protoplasts from the legume Samanea saman in both whole-cell and isolated-patch configurations. In the absence of either Mg2+ or ATP in the “cytosolic” solution, the KD channel activity declined completely within 15 min. This decline could be reversed in excised, inside-out patches by restoring MgATP (1 mM) to the cytoplasmic side of the membrane. Mg2+ (1 mM) plus 5[prime]-adenylylimidodiphosphate (1 mM), a nonhydrolyzable ATP analog, did not substitute for ATP. Mg2+ (1 mM) plus adenosine 5[prime]-O-(3-thiotriphosphate) (25 to <100 [mu]M), an irreversibly thiophosphorylating ATP analog, sustained channel activity irreversibly. 1–(5-IsoquinolinesulphonyI)-2- methylpiperazine (100 [mu]M), a broad-range kinase inhibitor, blocked the activity of KD channels in the presence of MgATP. These results strongly suggest that the activation of the outward-rectifying K channels by depolarization depends critically on phosphorylation by a kinase tightly associated with the KD channel.
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

There is currently a severe shortage of liver grafts available for transplantation. Novel organ preservation techniques are needed to expand the pool of donor livers. Machine perfusion of donor liver grafts is an alternative to traditional cold storage of livers and holds much promise as a modality to expand the donor organ pool. We have recently described the potential benefit of subnormothermic machine perfusion of human livers. Machine perfused livers showed improving function and restoration of tissue ATP levels. Additionally, machine perfusion of liver grafts at subnormothermic temperatures allows for objective assessment of the functionality and suitability of a liver for transplantation. In these ways a great many livers that were previously discarded due to their suboptimal quality can be rescued via the restorative effects of machine perfusion and utilized for transplantation. Here we describe this technique of subnormothermic machine perfusion in detail. Human liver grafts allocated for research are perfused via the hepatic artery and portal vein with an acellular oxygenated perfusate at 21 °C.
Control Scheme of Z-Source Inverter Based BLDC Motor Drive System Using Modified Pulse Width Modulation Technique

A modified pulse width modulation technique for Z-source inverter based BLDC motor is proposed and analyzed in this project.The Z-source inverter can be used as Buck/Boost converter with lower cost and high efficiency. BLDC motors are used in electric vehicles where portability and efficiency are required. This drive system provides advantages of both BLDC motors and Z-source inverter, and can be used in fuel cell system and other adjustable speed drive application. In this project principle of modified pulse width modulation technique is implemented and simulated. The model of a three phase Z-source inverter has been discussed based on modified pulse with modulation technique. The simulation of Z-source inverter based BLDC motor is done using the MATLAB/SIMULINK.
The First-Time in Private Equity : Does Experience Help to Raise Capital ?

Compared to mature investment firms, first-time funds in private equity lack an investment and performance track record, and require alternative signals to establish initial trust with investors. The paper finds that investors allocate more capital to first-time funds if they have a higher share of managers with relevant experience, such as from another private equity group or a bank. In particular, experience from high-reputation employers raises the fundraising outcome, while the relevance of experience with the same previous firm, heterogeneity in the exposure, and operational experience is limited at best.
Substantive Fluoride Release from a New Fluoride Varnish Containing CXP

Objective: A new fluoride varnish (Embrace™) containing xylitol-coated calcium and phosphate (CXP™) claims to release ten times more fluoride over a four-hour period than leading fluoride varnishes. The purpose of this study was to compare the quantity and rate of fluoride release from enamel of a newly marketed fluoride varnish compared to three other fluoride systems. Study design: Human third molars were cut into sections and Embrace™, Enamel Pro®, Duraphat®, or Vanish™ fluoride varnish were applied to the enamel surfaces. Specimens were immersed in synthetic saliva which was replaced at tested intervals. The concentration of fluoride in ppm was measured after specified hourly intervals during the first week and then weekly until the limit of detection (LOD). Mean cumulative fluoride release and rate of release were analyzed with a one-way ANOVA/Tukey (α=0.05). Results: Significant differences existed between groups (p Enamel Pro®>Duraphat®=Vanish™. Rate of fluoride depletion is Embrace™>Duraphat®=Enamel Pro®=Vanish™. Conclusions: Embrace™ had the greatest initial fluoride release, exceeding ten times the release of a leading fluoride varnish in the first four hours; however, Embrace™ had the highest rate of fluoride depletion and lowest substantivity of all varnishes tested.
Current status of prognostication in classical Hodgkin lymphoma

Classical Hodgkin lymphoma (cHL) is characterized by a paucity of neoplastic Hodgkin/Reed Sternberg (HRS) cells within a complex cellular milieu that is rendered immunologically incapable of reacting against CD30+HRS cells due to a plethora of immune escape mechanisms initiated by the neoplastic cells. Accounting for 25% of all lymphomas and nearly 95% of all Hodgkin lymphomas, patients with cHL are typically young adults. Besides traditional prognostic factors, such as the International Prognostic Index (IPI), newer imaging and ancillary biomarkers (CD68, Galectin‐1 and plasma microRNA) have shown promise. Furthermore, the evolution of gene expression profiling (GEP) in recent years has enabled the development of several practically feasible GEP‐based predictors with prognostic relevance. This review discusses the current status of clinical prognostication in cHL, the critical role of histological evaluation in light of several mimicking entities, and the relevance of tissue as well as serum biomarkers pertaining to immune escape mechanisms and recent GEP studies.
Role of irradiation in the suppression of parotid secretions

Abstract Suppression of salivary flow is of value in the management of salivary fistulae and sialectasia. It may also be beneficial in mentally defective patients and those with neurological palsies lacking control of their salivation. Nine patients were treated by irradiation to the parotid gland to control salivary flow; eight had complete resolution of symptoms and one had partial relief. Irradiation was effective as primary treatment and after failed surgery and/or drug treatment. Low doses were effective and there were no significant acute or long-term side effects. Its use avoids long-term medication and their potential side effects and may reduce the need for surgery.