Miracle-dz/UniFAR-FTUs huggingface dataset:
Interprofessional education in allied health: a systematic review

During the past decade, several studies have systematically reviewed interprofessional education (IPE), but few have inclusively reviewed this literature. None has focused primarily on IPE in allied health, despite differences in recruitment and socialisation across the health professions. This systematic review seeks to uncover the best approach to pre‐licensure, university‐based allied health IPE to determine which aspects require modification in which contexts to provide optimal learning experiences.
Phenotype at diagnosis predicts recurrence rates in Crohn’s disease

Background: In Crohn’s disease (CD), studies associating phenotype at diagnosis and subsequent disease activity are important for patient counselling and health care planning. Aims: To calculate disease recurrence rates and to correlate these with phenotypic traits at diagnosis. Methods: A prospectively assembled uniformly diagnosed European population based inception cohort of CD patients was classified according to the Vienna classification for disease phenotype at diagnosis. Surgical and non-surgical recurrence rates throughout a 10 year follow up period were calculated. Multivariate analysis was performed to classify risk factors present at diagnosis for recurrent disease. Results: A total of 358 were classified for phenotype at diagnosis, of whom 262 (73.2%) had a first recurrence and 113 patients (31.6%) a first surgical recurrence during the first 10 years after diagnosis. Patients with upper gastrointestinal disease at diagnosis had an excess risk of recurrence (hazard ratio 1.54 (95% confidence interval (CI) 1.13–2.10)) whereas age ⩾40 years at diagnosis was protective (hazard ratio 0.82 (95% CI 0.70–0.97)). Colonic disease was a protective characteristic for resective surgery (hazard ratio 0.38 (95% CI 0.21–0.69)). More frequent resective surgical recurrences were reported from Copenhagen (hazard ratio 3.23 (95% CI 1.32–7.89)). Conclusions: A mild course of disease in terms of disease recurrence was observed in this European cohort. Phenotype at diagnosis had predictive value for disease recurrence with upper gastrointestinal disease being the most important positive predictor. A phenotypic North-South gradient in CD may be present, illustrated by higher surgery risks in some of the Northern European centres.
Working in open innovation: How to determine networks and their relationship using techmining

This paper proposes how to foster open innovation through the establishment of collaborative networks. It displays how to elaborate and to visualize innovation networks existing through the analysis of the information contained in scientifical and technical databases. It comes to show two networks for innovation, made with text mining, the inventors network made upon information of the Intellectual property register and other network for innovation composed by authors of technical papers. These developments applying tech-mining techniques will allow companies to interact with numerous other companies and experts in every part of the world. Results can be of value to researchers, research managers, public institutions or decision makers in general who need to keep abreast of changing technical domains and anticipate future developments or establish for further knowledge transfer partnerships. The concept and application of open innovation and its collaborative networks will be integrated in the future innovation management systems.
Multicenter trial validation for quantitative analysis of same-day rest-stress technetium-99m-sestamibi myocardial tomograms.

UNLABELLED The accuracy of an automated quantitative analysis of same-day rest/stress 99mTc sestamibi SPECT images for detection and localization of coronary artery disease (CAD) was assessed in a multicenter trial consisting of 161 patients from 7 different clinical sites utilizing various camera computer systems. METHODS Of the 161 patients, 102 had angiographically documented coronary artery disease, 22 had normal coronary arteriograms, and 37 had a low (< 5%) likelihood of coronary artery disease based on their age, sex, symptoms and the results of their exercise electrocardiograms. The patients were studied using previously optimized image acquisition and processing protocols. An additional population consisting of 45 patients with single-vessel disease were evaluated to determine the optimal criteria for detection of CAD. RESULTS The quantitative analysis method was associated with an overall sensitivity of 87%, specificity of 36%, and normalcy rate (true negative rate in the low likelihood patients) of 81%. Sensitivity for overall detection of disease was similar (90%) in patients with and without myocardial infarction (90% versus 89%). The sensitivities and specificities for identification of disease in individual coronary arteries were, respectively, 69% and 76% for LAD, 70% and 80% for LCX, and 77% and 85% for RCA. CONCLUSION The results of this study demonstrate that the new objective quantitative method for analysis of same-day rest/stress 99mTc sestamibi SPECT images is accurate for detection and localization of CAD and correlates highly with expert visual interpretation.
SEVERE CASES OF PEDIATRIC TUBERCULOSIS

Pediatric tuberculosis (TB) represent a warning sign in a community, as it could signal recent TB infection of a contagious form in an adult. Rapid diagnosis is very important for effective treatment in children, and it is mandatory for the efficient control of tuberculosis at the public health level, since it allows rapid identification of contagious adult cases. Here we report three severe cases of TB in children, one of them occurred in a HIV positive patient. These cases stress the need for an extensive medical history, a complete clinical and physical examination of the patient and radiological examination during diagnostic work-up. This includes: the positive history for contact with infected adults; the presence of risk factors; the evaluation of the immunological status; exclusion of TB diagnosis for persistent respiratory symptoms (2-3 weeks) after antibiotic therapy; the presence of radiographic abnormalities and the detection and isolation of the Mycobacterium Tuberculosis in the appropriate specimens for bacteriological examination. Early diagnosis and treatment are extremely important once tuberculosis is suspected, to improve survival and prevent morbidity.
Relationship of Serum Magnesium and Vitamin D Levels in a Nationally-Representative Sample of Iranian Adolescents: The CASPIAN-III Study

Background: This study aims to assess the relationship of serum Mg and vitamin D levels in a nationally-representative sample of Iranian adolescents. Methods: The study participants consisted of 330 students, aged range from 10 to 18 years, consisting of an equal number of individuals with and without hypovitaminosis D. The correlation between serum 25 hydroxy vitamin D (25(OH) D) and magnesium (Mg) concentrations was determined. Results: The mean age of participants was 14.74 ± 2.587 years, without significant difference between those with hypovitaminosis D and those without it. The mean 25(OH) D level was 6.34 ± 1.47 ng/ml in the group with hypovitaminosis D and 39.27 ± 6.42 ng/ml in the group without it. The mean Mg level was 0.80 ± 0.23 mg/dl with lower level in the group with hypovitaminosis D than in others (0.73 ± 0.22 mg/dl vs. 0.87 ± 0.22 mg/dl, respectively) and according to t-test analysis, significant lower levels in the deficient group was observed (P = 0.0001). The linear regression analysis showed the meaningful relationship between Mg and 25(OH) D serum levels (P = 0.0001). Conclusions: Our study revealed significant associations between serum Mg and 25(OH) D levels. This finding may be of use for further studies on the prevention and management of hypovitaminosis D in children and adolescents. Further longitudinal studies shall evaluate the underlying mechanisms and the clinical significance of the current findings.
Social Capital and Happiness Among Health Sector Personnel in Iran

Background: Happiness and its associated factors are of critical importance in human health. Objectives: This study was conducted to examine the association between social capital (social relations) and happiness among health personnel in Iran. Methods: In this cross sectional study, 537 health personnel were selected from the West of Iran through stratified random sampling. The study tools included a demographic checklist, a social relations questionnaire, and Oxford happiness inventory (OHI). For statistical analysis, independent t test, ANOVA, Pearson’s correlation test, and multiple regression analysis were performed, using SPSS version 18 and AMOS software. Results: Among happiness dimensions, the mean score of “sense of vitality” was significantly higher in men, compared to women (P < 0.05). The results of multiple regression analysis showed that family relations had the greatest direct effect on “life satisfaction” (β, 298; P < 0.01) and “positive affect” (β, 0.257; P < 0.01). Gender played a mediating role only between workplace relations and happiness (P = 0.004). In addition, canonical correlation analysis indicated that 23.5% of variance in the happiness components could be predicted by the components of social relations, based on the Wilks’ lambda (0.765). Conclusions: The findings showed that family and family relations are still the most important sources of happiness. Reinforcement of social relations, as the central aspect of social capital, can play an essential role in increasing happiness in different social groups.
Chitinophaga barathri sp. nov., isolated from mountain soil.

A Gram-stain-negative, non-motile, rod-shaped, aerobic bacterium, designated strain YLT18T, was isolated from mountain cliff soil of Enshi Grand Canyon in China. The major menaquinone was menaquinone 7 (MK-7) and the predominant fatty acids (>5 %) were iso-C15 : 0, C16 : 1ω5c, iso-C17 : 0 3-OH, summed feature 3 (C16 : 1ω7c/iso-C15 : 0 2-OH) and iso-C15 : 0 3-OH. The major polar lipids were phosphatidylethanolamine, two unknown aminophospholipids, two unknown aminolipids and two unknown polar lipids. The DNA G+C content was 55.4 mol%. According to phylogenetic analysis based on 16S rRNA gene sequences, strain YLT18T was related most closely to Chitinophaga niabensis JS13-10T ( = DSM 24787T) and Chitinophaga cymbidii R156-2T ( = KCTC 23738T), with similarities of 96.7 and 96.2 %, respectively. In addition, strain YLT18T showed obvious differences from the closely related species in terms of esterase (C4) activity, acid production from fructose and rhamnose, and sole carbon source utilization by arabinose and rhamnose. The results from this polyphasic taxonomic study revealed that strain YLT18T represents a novel species of the genus Chitinophaga, for which the name Chitinophaga barathri sp. nov. is proposed. The type strain is YLT18T ( = KCTC 42472T = CCTCC AB 2015054T).
Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort

Background: Pancreatic autoantibodies (PAB) and goblet cell autoantibodies (GAB) are specific for Crohn's disease (CD) and ulcerative colitis (UC), but the sensitivity alone is low. Conventional antibodies and carbohydrates (glycans) are associated with disease phenotype and may be of diagnostic importance in inflammatory bowel disease (IBD). Our aim was to determine the accuracy of PAB and GAB autoantibodies as well as to study relevant phenotype–serotype associations. Methods: A Hungarian study cohort of 1092 subjects, including 689 well‐characterized, unrelated IBD patients (CD: 579, m/f ratio: 274/305, duration: 7.9 ± 11.2 years; UC: 110, m/f ratio: 53/57, duration: 8.9 ± 9.8 years), 139 celiac patients, 100 healthy, and 64 non‐IBD gastrointestinal controls were investigated. Sera were assayed for PAB‐GAB IgA/IgG, anti‐Omp, anti‐Saccharomyces cerevisiae antibodies (ASCA), and anti‐glycans. TLR4 and NOD2/CARD15 was tested by polymerase chain reaction / restriction fragment length polymorphism (PCR‐RFLP). Detailed clinical phenotypes were determined. Results: The prevalence of PAB was significantly more frequent in CD (41.1%) versus UC (22.7%), celiac (22.3%), and controls (8% and 4.6%, P < 0.01 for each), while GAB detection was poor in all groups except UC (15.4%). In CD the combination of PAB and/or anti‐glycans/ASCA increased the sensitivity to 72% and 59%, respectively, for isolated colonic disease. PAB was associated to gylcans (odds ratio [OR] 1.74,P = 0.002), ASCA IgG/IgA (OR 1.75, P = 0.002), Omp (OR 1.86, P = 0.001) as well as perforating, perianal disease, arthritis, ocular, and cutaneous manifestations (P = 0.002–0.032). In contrast, PAB and GAB antibodies were not associated with NOD2/CARD15 or TLR4, response to medical therapy, or need for surgery. No associations were found in UC. Conclusions: PAB autoantibodies in combination with ASCA or anti‐glycan antibodies increase the sensitivity for detecting CD, especially isolated colonic CD. Antibody response to PAB was associated with complicated disease phenotype and extraintestinal manifestations in this Eastern European IBD cohort.
Overestimation of genetic risks owing to small sample sizes in cardiovascular studies

We sought evidence of publication bias to explain conflicting findings in studies of angiotensin‐converting enzyme deletion polymorphism (ACE D) and glycoprotein IIIa PlA2 (PLA2) polymorphism and the risk of myocardial infarction. Factor 5 Leiden (F5L), a well‐established thrombotic risk factor, served as an internal comparison. We conducted systematic reviews of published studies involving ACE D, PLA2, F5L and relevant outcomes, searching medline (January 1990 through February, 2001), bibliographies, and meta‐analyses. Random effects pooled odds ratios (95% confidence interval) for cardiovascular outcomes were as follows: PLA2 (n = 13,167 subjects): 1.13 (1.02, 1.26); ACE D (n = 42,140 subjects): 1.22 (1.11, 1.35); and F5L (n = 27,277 subjects): 4.43 (3.65, 5.38). However, funnel plots of ACE D and PLA2, but not F5L, showed an inverse relationship between sample size and odds ratios for ACE D (p = 0.02) and PLA2 (p = 0.04) but not F5L (p = 0.65) by Egger's test for potential publication bias. Despite research‐based genotyping of over 50,000 subjects, the overall risk for myocardial infarction as a result of PLA2 and ACE D remains doubtful. Our study provides a clear example of how publication of underpowered studies can spuriously implicate polymorphisms as genetic risk factors.
Research priorities and best practices for managing climate risk and climate change adaptation in Australian agriculture

ABSTRACT The challenges of climate change adaptation in agriculture are examined through the lens of priorities for research, and the use of best management practices (BMPs) to better manage climate risks. The methods and results have two parts. Firstly, a case study from the northern grains region examines the use of BMPs for managing climate risks associated with both climate variability and climate change. A series of industry workshops developed and tested a suite of 24 BMP standards for growing dryland grain crops, including four BMPs on risk management based on the Australian Standards for Risk Management. Secondly, priorities for research on climate change adaptation in the primary industries sector are described and evaluated to assess needs for updating, in response to industry and environmental changes. The analysis reveals strong reasons for increasing the priority given to education and extension on risk management and for developing BMPs for both incremental and transformative adaptation, and especially for deriving methods to achieve widespread adoption of BMPs for managing extreme climatic events. Collaborative development of BMPs involving farmers’/industry/scientists is the process most likely to derive robust BMPs to withstand the complexities of climate risk and build greater resilience of communities and ecosystems.
Mixed Signal Interface Chip for Wearable Healthcare System

Smart sensors, which are created by combining sensing materials with integrated circuitry are being considered for several biomedical application such as a glucose level ,temperature ,Ecg ,etc. Practical usability of the majority of current wearable body sensor systems for multiple parameter physiological signal acquisition is limited by the multiple physical connections between sensors and the data-acquisition modules. In order to improve the user comfort and enable the use of these types of systems on active mobile subjects, a wireless body sensor system that incorporates multiple sensors on a single node is proposed [10]. The system must be suitable for longer-term monitoring of the subjects, such as continuous wear and autonomous operation up to several days without replacement of the power source. Thus power consumption is a major challenge in these applications. The sensing and read-out of the signals may draw a significant part of the power budget in today’s sensor nodes in WBAN, especially when the number of signals or channels is increasing. Thus, reducing the power required for signal extraction is an important challenge. Many system-on-chip (SoC) solutions have been presented for multiparameter sensor systems, but these do not offer application engineers the freedom of tailoring modules in their system to suit their specific application.
Comparison of quantitative cDNA‐PCR with the branched DNA hybridization assay for monitoring plasma hepatitis C virus RNA levels in haemophilia patients participating in a controlled interferon trial

The branched DNA (bDNA) assay was compared with a semi‐quantitative cDNA‐polymerase chain reaction (cDNA‐PCR) assay for monitoring HCV RNA levels in plasma in 17 haemophilia patients participating in a controlled a‐interferon trial. Good correlation between the HCV RNA levels as detected by the two assays was observed, with a correlation co‐efficient of 0.83 (P < 0.0001) and 0.90 (P < 0.0001) at week 0 and 24, respectively. Hepatitis C virus RNA (HCV RNA) levels could be assessed with the bDNA assay in 14/17 (82 percent) HCV cDNA‐PCR positive pre‐treatment samples. The bDNA assay apparently failed to detect low viral titres. (riterferon treated patients (n = 11) showed either a complete response, being a large reduction in HCV RNA level to below the detection limit of the HCV cDNA‐PCR assay (6/11) or no significant reduction in HCV RNA level (5/11). A “partial” virological response was not observed. The changes in HCV RNA plasma levels in non‐responders during interferon (IFN) treatment were similar to the (small) natural fluctuations in viral load observed in controls (untreated patients). Although the bDNA assay was not as sensitive as cDNA‐PCR, given its user friendliness and quantitative results, it is concluded that it is a useful test for monitoring HCV RNA levels in patients treated with interferon. However, patients who are non‐reactive in the bDNA assay have to be retested by cDNA‐PCR because low viral titres are not detected by the bDNA assay. © 1994 Wiley‐Liss, Inc.
Neuropsychological deficits in schizophrenics. Relationship to age, chronicity, and dementia.

BACKGROUND We sought to determine whether neuropsychological impairment in schizophrenia is related to current age, age at onset, or duration of illness, and whether the pattern of such impairment can be distinguished from that caused by progressive dementias of Alzheimer's type. We administered a comprehensive neuropsychological test battery to a normal control group (n = 38), a group of ambulatory patients with Alzheimer's disease (n = 42), and three ambulatory schizophrenic groups: early onset-young (n = 85), early onset-old (n = 35), and late onset (n = 22). Tests were grouped and analyzed according to eight major ability areas, and published procedures were used to remove the expected effects of normal aging. RESULTS The three schizophrenic groups were found to be neuropsychologically similar to one another and different from normal controls and patients with Alzheimer's disease. There were no significant differences among the schizophrenic groups in level or pattern of neuropsychological functioning. Patients with Alzheimer's disease demonstrated less efficient learning and particularly more rapid forgetting than did the other groups. CONCLUSIONS These findings suggest that neuropsychological impairment in schizophrenia is unrelated to current age, age at onset, or duration of illness. The study further suggests that the encephalopathy associated with schizophrenia is essentially nonprogressive and produces a pattern of deficits that is different from that seen in progressive cortical dementias.
Effect of ozone therapy on muscle oxygenation.

BACKGROUND AND OBJECTIVE Ozone therapy is being used to treat ischemic disorders. However, the underlying mechanisms for the success are unknown and the therapy has not been accepted fully within conventional medicine. This study sought to assess the effect of ozone therapy on resting muscle oxygenation. PATIENTS AND DESIGN Twenty-three (23) patients and 3 volunteers were recruited for this prospective study. Systemic ozone therapy was administered by autohemotransfusion on three alternate days over 1 week. Tissue oxygenation (mmHg) was directly measured in the tibialis anterior muscle using polarographic needle electrodes before and after the first and the third ozone therapy session. RESULTS Globally, the differences in oxygenation were not statistically significant but there was a significant decrease in the percentage of low-oxygenated values (pO(2) < 5 mmHg) following ozone sessions (p < 0.02). The change in muscle oxygenation following ozone therapy was inversely correlated with age (r = -0.398; p = 0.044) and with the initial (baseline pretherapy) muscle oxygenation values (r = -0.644; p < 0.001), indicating that the more poorly oxygenated muscles benefited most from the therapy. A significant (p = 0.031) higher oxygenation in these tissues was observed 48 hours after the second session. CONCLUSIONS Ozone therapy can modify oxygenation in resting muscles, particularly of those that are most hypoxic. Our results suggest that ozone therapy could be used effectively as a complementary treatment of hypoxic and ischemic syndromes and that the therapy warrants further investigation for possible application in other clinical conditions.