Miracle-dz/UniFAR-FTUs huggingface dataset:
Einfluss von Flickerlicht auf den retinalen Gefäßdurchmesser unter Berücksichtigung des weiblichen Hormonzyklus innerhalb eines Monats

Fragestellung Inwieweit beeinflussen die hormonellen Schwankungen im Laufe eines normalen weiblichen Zyklus die Reaktion der retinalen Gefase auf optische Stimuli? Methodik Im Laufe eines Monats wurden dreimal (am 3.-5. Zyklustag, zur Ovulation und zwischen dem 19.-23. Zyklustag) die retinalen Gefasdurchmesser der Venen und Arterien von 25 gesunden Frauen (mittleres Alter: 24,1 Jahre, [18-30] Jahre) mit dem Retinal Vessel Analyzer (RVA der Firma Imedos, Jena) vermessen. Jede Untersuchung dauerte uber 350 Sekunden, mit einer Vorlaufzeit von 50 Sekunden, zur Messung des Ausgangswerts, gefolgt von jeweils drei Flickerperioden von 20 Sekunden, mit einer Nachbeobachtungszeit von jeweils 80 Sekunden. Die Dilatation und Kontraktion der Arterien bzw. die Dilatation der Venen wurde als prozentuale Differenz zum Ausgangswert angegeben. Ergebnis Die maximale arterielle Kontraktion nahm zwischen der Ovulation und der Lutealphase zu (p=0,022), wahrend die maximale arterielle Dilatation im Vergleich der fruhen Follikel- und der Lutealphase abnahm (p=0,008). Vergleicht man die dilatative Reaktion der Arterien adjustiert zum Ruhediameters, ist auch eine Abnahme zwischen der fruhen Follikelphase und der Ovulation nachweisbar (p=0,048). Dagegen zeigte die Reaktion der Venen keine Veranderung im Zyklusverlauf. In einer Korrelationsanalyse der zwei-phasischen Flickerantwort der retinalen Gefase mit den gemessenen Ostrogen- und Progesteronkonzentrationen im Blut konnten keine direkten Abhangigkeiten gesichert werden. Schlussfolgerung Die abnehmende Dilatation und zunehmende Kontraktion der Retinaarterien in der Lutealphase lassen einen zyklusabhangignen Effekt insbesondere von Progesteron auf die Flickerreaktion der retinalen Gefase vermuten. Zur Standardisierung der Messung sollte in der ophthalmologischen Forschung und Praxis bei pramenopausalen Frauen die Durchfuhrung der Messungen in der fruhen Follikelphase durchgefuhrt werden.
Technologie et régulations dans les organisations : le cas de l'ordre de bourse dans les salles de marché

La question de la regle est d'abord traitee d'une facon tres theorique, et pour le moins statique, par les Philosophes et les Peres de la sociologie. Introduire l'acteur dans le raisonnement conduit a lui donner une forme dynamique et a etudier a la fois son origine et ses evolutions, mais aussi sa diversite. Routines, conventions, et regulations sont autant de formes revetant des implications differentes, notamment en termes de controle.La technique intervient ainsi sur ce dernier point. Devenue omnipresente et indiscutable dans nos quotidiens, elle n'est pourtant pas une notion evidente et anodine.C'est surtout le lien entre les trois variables cites, acteur, regulation et technologie qui retient notre attention. Il fait naitre une notion de regulation socio materielle, reintroduisant dans un propos theorique la matiere qui pondere une technologie devenue moins visible.Adoptant la methode de l'etude de cas pour etudier cette problematique, nous nous attacherons, en etudiant le processus de passage d'ordre de Bourse, a mettre en evidence les articulations concretes des notions et les differents processus reglementaires qu'elles produisent.
Differentiating Sitting and Lying Using a Thigh-Worn Accelerometer.

UNLABELLED A triaxial accelerometer worn on the thigh can provide information on the angle of rotation of the thigh. These data may be used to estimate periods of lying versus sitting. PURPOSE To develop and test a classification algorithm to identify sedentary events as either lying or sitting events using a thigh-worn, triaxial accelerometer. METHODS Seven-day free-living activity from 14 sedentary workers was recorded using the activPAL3™ monitor. Participants recorded when they went to bed and when they got up in a diary. All "in-bed" sedentary events were assumed to be lying and all "not-in-bed" sedentary events as sitting. An algorithm computed the angle of rotation of the y-axis, which was used to detect orientation of the thigh. Crossing a rotational threshold in the transverse plane of ±65° was used to classify a sedentary event as lying. The classification accuracy of the algorithm was compared with self-reported classification from the diary. RESULTS The algorithm classified 96.7% of the sedentary time "in bed" (sensitivity) as lying and 92.9% of the time "not in bed" as not lying (specificity). CONCLUSIONS Triaxial accelerometer data recorded from a single site on the thigh can be used to classify sedentary events as sitting and lying. The automated method developed in this study will allow objective measurement of diurnal lying time and that while sleeping without relying on self-report. This will help advance the understanding of the impact of different types of sedentary behaviors on various health outcomes.
Approximate Polynomial Common Divisor Problem Relates to Noisy Multipolynomial Reconstruction

In this paper, we investigate the hardness of the approximate polynomial common divisor problem, which is regarded as a polynomial analogy of the approximate integer common divisor problem. In order to solve this problem, we present a simple method by using the polynomial lattice reduction algorithm and contain complete theoretical analyses. Further, we propose an improved lattice attack to reduce both space and time costs. Moreover, these two attacking methods can be directly applied to solving the noisy multipolynomial reconstruction problem in the field of error-correcting codes. On the basis of the above situations, our improved lattice attack performs fastest.
Triple Scoring Using Paragraph Vector - The Gailan Triple Scorer at WSDM Cup 2017

In this paper we describe our solution to the WSDM Cup 2017 Triple Scoring task. Our approach generates a relevance score based on the textual description of the triple's subject and value (Object). It measures how similar (related) the text description of the subject is to the text description of its values. The generated similarity score can then be used to rank the multiple values associated with this subject. We utilize the Paragraph Vector algorithm to represent the unstructured text into fixed length vectors. The fixed length representation is then employed to calculate the similarity (relevance) score between the subject and its multiple values. Our experimental results have shown that the suggested approach is promising and suitable to solve this problem.
Descemet membrane endothelial keratoplasty with a stromal rim in the treatment of posterior polymorphous corneal dystrophy

A 20-year-old patient, diagnosed with posterior polymorphous corneal dystrophy, developed corneal edema for which he underwent Descemet membrane endothelial keratoplasty with a stromal rim (DMEK-S) in the right eye. No intra- or postoperative complications were noted. At the last follow-up 2 years and 9 months after the procedure, the best corrected visual acuity was 1.0 and endothelial cell density declined from 3533 cells/mm2 to 1012 cells/mm2. Despite the endothelial cell loss, DMEK-S appears to be a good alternative to other surgical techniques for the treatment of corneal endotheliopathies, and it may be of benefit to young patients.
REST-style Actionscript programming interface for message distribution using Amazon Simple Queue Service

Amazon Simple Queue Service (Amazon SQS) is a message-oriented middleware in the cloud using software as a service model. It aims to eliminate the traditional overhead associated with operating in-house messaging infrastructures by providing reduced costs, simplified access to messaging resources, scalability and reliability. In order to provide those benefits Amazon SQS leverages cloud resources such as storage, network, memory, processing capacity. Using virtually unlimited cloud computing resources, an Amazon SQS provides an internet scale messaging platform. This paper presents benefits and examples of Amazon SQS programming interface developed in Actionscript 3.0 object-oriented programming language. This interface was developed to enable Adobe Flex mobile developers to facilitate integration efforts within organizations and between them using mobile devices (tablets and smartphones).
MULTIPLE NIGHT-TIME DOSES OF VALERIAN (Valeriana officinalis) HAD MINIMAL EFFECTS ON CYP3A4 ACTIVITY AND NO EFFECT ON CYP2D6 ACTIVITY IN HEALTHY VOLUNTEERS

Valerian (Valeriana officinalis) is a popular dietary supplement. The objective of this study was to assess the influence of a valerian extract on the activity of the drug-metabolizing enzymes cytochrome P450 2D6 (CYP2D6) and 3A4. Probe drugs dextromethorphan (30 mg; CYP2D6 activity) and alprazolam (2 mg; CYP3A4 activity) were administered orally to healthy volunteers (n = 12) at baseline and again after exposure to two 500-mg valerian tablets (1000 mg) nightly for 14 days. The valerian supplement contained a total valerenic acid content of 5.51 mg/tablet. Dextromethorphan to dextorphan metabolic ratios (DMRs) and alprazolam pharmacokinetics were determined at baseline and after valerian treatment. The DMR was 0.214 ± 0.025 at baseline and 0.254 ± 0.026 after valerian supplementation (p > 0.05). For alprazolam, the maximum concentration in plasma was significantly increased after treatment with valerian (25 ± 7 ng/ml versus 31 ± 8 ng/ml; p < 0.05). There were no significant differences in other pharmacokinetic parameters at baseline and after valerian exposure (all p values ≥0.05; time to reach maximum concentration in plasma, 3.0 ± 3.2 versus 3.1 ± 2.1 h; area under the plasma concentration versus time curve, 471 ± 183 versus 539 ± 240 h · ng · ml-1; half-life of elimination, 13.5 ± 4.3 versus 12.2 ± 5.6 h). Our results indicate that although a modest increase was observed in the alprazolam Cmax, typical doses of valerian are unlikely to produce clinically significant effects on the disposition of medications dependent on the CYP2D6 or CYP3A4 pathways of metabolism.
Ring chromosome 12 resulting from nonrandom telomeric associations with the short arm of chromosome 15 in a cerebellar astrocytoma

Ring chromosome 12 was found in an untreated cerebellar astrocytoma apparently resulting from nonrandom telomeric associations involving the short arm of chromosome 15, and both the long and short arms of chromosome 12. The clonal nonrandom telomeric associations of 15p to both ends of the chromosome 12 were transitory, but appear to be the precursor lesion in the evolution to ring chromosome 12 in this tumor. A multistep process in the formation of a ring chromosome resulting from nonrandom telomeric associations to both telomeres is illustrated. © 1993 Wiley‐Liss, Inc.
Comparison of BACTEC 9240 and BacT/Alert blood culture systems in an adult hospital

In a study comparing the BACTEC 9240 (Becton Dickinson, Canada Inc., Mississauga, Ontario, Canada) and the BacT/Alert (Organon Teknika, Scarborough, Ontario, Canada) blood culture systems, 6,437 sets of four bottles of 10,412 cultures submitted were deemed acceptable for evaluation. There were 586 clinically significant isolates from 544 positive blood cultures. Of the 544 positive blood cultures, 329 were positive in both systems, 157 were positive in the BACTEC 9240 system alone, and 58 were positive in the BacT/Alert system alone (P < 0.001). These cultures represented 421 bacteremic episodes, of which 290 were detected by both systems, 84 were detected by the BACTEC 9240 system alone, and 47 were detected by the BacT/Alert system alone (P < 0.001). The difference between the two systems in terms of microbial recovery was attributable largely to differences in the ability to grow staphylococci. Of 82 monomicrobial isolates of Staphylococcus aureus, 46 were isolated by both systems, 30 were isolated by the BACTEC 9240 system alone, and 6 were isolated by the BacT/Alert system alone (P < 0.0001). A similar pattern was noted in the case of coagulase-negative staphylococci, of which 48 were isolated in both systems, 46 were isolated in the BACTEC 9240 system alone, and 5 were isolated in the BacT/Alert system alone (P < 0.0001). The false-positive rate in the BACTEC 9240 system was 0.5%, and that in the BacT/Alert system was 1.2%. Both systems provided satisfactory service mechanically, and in terms of computer software and costs, both systems were similar. The differences in the recovery of organisms, notably staphylococci, may be due in part to the fact that in the present study the BacT/Alert medium did not contain antimicrobial agent-removing devices, whereas the BACTEC 9240 medium did. Until this difference is resolved, we consider the BACTEC 9240 system to more adequately meet our hospital's requirements.
Culturability and Viability of Salmonella Typhimurium during Photo-Fenton Process at pH 5.5 under Solar Simulated Irradiation

Culturability and viability techniques such as plate count on solid agar (PC), Most Probable Number (MPN) and Direct Viable Count-Fluorescence in Situ Hybridation (DVC FISH) were used to study the inactivation of Salmonella typhimurium by photo-Fenton process at pH 5.5. In the presence of only simulated solar irradiation (500 W·m-2), S. typhimurim showed that both culturability measured by MPN and viability (measured by DVC FISH) underwent just a slight decreasing of 2 and 1 log respectively after 240 min of light exposition while culturability measured by PC did not show any change. Results after 48 h of dark conditions did not reveal re-growth. However, when experiment was carried out in the presence of 2 mg L-1 of Fe3+ and 20 mg L-1 of H2O2 and pH 5.5, culturability was strongly affected after 240 min of simulated solar irradiation; nevertheless, viability was only slightly altered (~1 log). During dark period of 48 h changes on culturability and viability were not observed. On the other hand, it was also found that sugar metabolism was affected rather the amino-acids in S. typhimurium cells irradiated at different times upon photo-Fenton conditions. These findings might suggest for the first time that photo-Fenton process at pH 5.5 could induce viable but nonculturable state (VBNC) on waterborne S. typhimurium and that probably sugar metabolism damage could activate the VBNC state.
Effect of the novel T-selective calcium channel antagonist mibefradil on kidney function in comparison with amlodipine.

In the present study, the renal effects of mibefradil (CAS 116666-63-8), a novel calcium channel antagonist which more selectively blocks T-type than L-type calcium channels, was tested by applying clearance techniques to anaesthetized rats. The effects of mibefradil on kidney function and on arterial blood pressure were compared with those of the long acting dihydropyridine-type calcium antagonist amlodipine (CAS 88150-42-9). The results show that, within a dosage range of 0.1 to 1.0 mg/kg i.v. , mibefradil induced a dose-dependent decrease of arterial blood pressure. Kidney function was not significantly affected at a dose of 0.1 mg/kg. By increasing the dose to 0.3 mg/kg, mibefradil induced a significant increase in urine flow, renal sodium, chloride and potassium excretion. Also fractional sodium and chloride excretions were significantly enhanced at this dose. The diuretic and saluretic effects of mibefradil were accompanied by a significant increase in the glomerular filtration rate. At the highest dose of 1 mg/kg used, the blood pressure lowering effect of mibefradil was most pronounced and glomerular filtration rate rose only slightly and not significantly. At this dose, the enhancement of urine flow and urinary electrolyte excretion was smaller than at the dose of 0.3 mg/kg. The actions of mibefradil were qualitatively similar to those of the dihydropyridine derivate amlodipine which at a dose of 0.3 mg/kg produced nearly identical renal effects to mibefradil, but exerted stronger antihypertensive effects. This study demonstrates that mibefradil shares with amlidopine the property to induce, at appropriate doses, diuretic and saluretic effects with a concomitant increase in glomerular filtration rate.
Rpe65 as a modifier gene for inherited retinal degeneration

Light accelerates progression of retinal degeneration in many animal models of retinitis pigmentosa (RP). A sequence variant in the Rpe65 gene (Rpe65450Leu or Rpe65450Met) can act as a modulator of light‐damage susceptibility in mice by influencing the kinetics of rhodopsin regeneration and thus by modulating the photon absorption. Depending on exposure duration and light intensity applied, white fluorescent light induces photoreceptor apoptosis and retinal degeneration in wild‐type mice by the activation of one of two known molecular pathways. These pathways depend, respectively, on activation of the transcription factor c‐Fos/AP‐1 and on phototransduction activity. Here we tested Rpe65 as a genetic modifier for inherited retinal degeneration and analysed which degenerative pathway is activated in a transgenic mouse model of autosomal dominant RP. We show that retinal degeneration was reduced in mice expressing the Rpe65450Met variant and that these mice retained more visual pigment rhodopsin than did transgenic mice expressing the Rpe65450Leu variant. In addition, lack of phototransduction slowed retinal degeneration whereas ablation of c‐Fos had no effect. We conclude that sequence variations in the Rpe65 gene can act as genetic modifiers in inherited retinal degeneration, presumably by regulating the daily rate of photon absorption through the modulation of rhodopsin regeneration kinetics. Increased absorption of photons and/or light sensitivity appear to accelerate retinal degeneration via an apoptotic cascade which involves phototransduction but not c‐Fos.
Association between dietary iron, iron stores, and serum lipid profile in reproductive age women

Background: Some studies have shown that increased rate of iron stores even in a normal range may increase cardiovascular diseases (CVDs) in some individuals. Lipid disorders are also the risk factors for CVDs. Therefore, the question is whether or not iron store is correlated with lipid profile, this study evaluates the association between dietary iron, iron stores and serum lipid profiles. Materials and Methods: This cross-sectional study was done on 82 healthy university students and university staff females in Isfahan University of Medical Sciences who were in reproductive age and announced their readiness to participate in the study. Serum ferritin concentration, components of lipid profile, blood glucose, and insulin were measured in all the subjects. Dietary intake was assessed by semi-quantitative food frequency questionnaire. Data analysis was done through SPSS software, version 18. Results: Pearson correlation test showed a positive and significant correlation between serum ferritin concentration levels with triglyceride (r = 0.278; P = 0.006), total cholesterol (r = 0.267; P = 0.008), and blood glucose (r = 0.275; P = 0.006); however, the correlation between serum ferritin, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and insulin was not significant. After adjustment of confounding factors, only the significant correlation occurred for blood glucose (P = 0.016). Before and after adjustment of confounding factors, there was no significant correlation between hemoglobin and hematocrit with concentration of lipid profile components, glucose and insulin. Before and after adjustment of confounding factors, there was no significant correlation between total amount of iron, heme iron, and non-heme dietary iron with concentration of lipid profile components, glucose and insulin. Conclusion: According to the current study, serum ferritin is directly and significantly correlated with concentration of fasting blood glucose, which emphasized on the amount of iron store with blood glucose even in healthy people. The results of the present study indicate no significant correlation between iron store and dietary iron intake with lipid parameters and insulin. Conducting more extensive epidemiologic studies in men and other age groups is recommended.
Weight based fish school search

This work further investigates how weight based FSS (i.e. almost only use of local information) can impact in the automatic splitting the school for solution of multimodal bench mark problems. The chief modification to standard FSS, in order to produce the wFSS, was the introduction of a relationship among fish solely relying on factual already existing indications of individual success. The implementation resulted in a lighter algorithm (when compared to other FSS attempts to solve multimodal problems) and a method that produces more suitable solution candidates for optimization problems. Following a complexity analysis, that reveal a reduction from , a thorough performance comparison with two other competing techniques was carried out using four different metrics, highly appropriate to assess multiobjective optimization. The experiments showed the upper hand of wFSS in multimodal continuous optimization adherent to the design decisions of (i) no use of global information for splitting the swarm, (ii) no heavy increase in computational costs to FSS and (iii) abidance to the original principle of FSS of not using topological information to solve the optimization problem. Keywords—Heuristic Search; Multi-Solution Optimization; Multimodal Problems; Fish School Search.
Microfluidic enabled rapid bioprinting of hydrogel μfiber based porous constructs

A rapid and high-resolution bioprinter based on a capillary coaxial microfluidic printer head and vacuum substrate, was conceived and built up in this work. We demonstrate the printing of porous (400 μm pitch) 3D bio-scaffolds made from calcium alginate microfibers with a printing resolution (i.e. fiber diameter) of ca. 150 microns, at a speed of 40 mm/s, which is approximately 10x faster than existing systems with comparable resolution.
Effect of path or sink anoxia on sugar translocation in roots of maize seedlings.

After feeding the scutellum of young maize seedlings with a labeled analog of glucose, 2-deoxy-d-glucose, the progress of radioactivity along the root was followed when either 70% of the path or the whole root were in strict anoxic conditions, and was compared with the translocation pattern of aerobic seedlings. Special care was taken to suppress the internal O(2) transport and to control its occurrence.In air, the radioactive compounds accumulated from 30 minutes in the root tip mainly as an analog of sucrose. When the whole root was anoxic, the progress of the radioactivity was very slow and never reached the tip which did not survive more than 8 hours. When 70% of the path was in strict anoxia and the sink (root tip) in air, the translocation was not impaired and the radioactivity accumulated in the tips as fast as in aerobic controls. The addition of 3 millimolar NaF, which inhibits the fermentative energy production, did not modify these results. It is concluded that long distance transport in maize sieve tubes has no special energy requirements and is controlled by source-sink relationships. The inhibition of sugar supply in anoxic root tips is attributed to an effect on unloading processes rather than on sink metabolism.