Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting the amount of air traffic demand regulations using machine learning

Demand for air transportation is expected to continue growing. Within Europe one of the biggest impacts of this traffic growth, is an increase of air travel delay. As it happened during the summer of 2018, where demand from aircraft intending to enter an air sector was not complemented with capacity to safely accommodate it. Incentivised by this event, in this article the problem of predicting a class of measures for demand-capacity balancing, known as Air Traffic Flow and Capacity Management (ATFCM) regulations, is investigated. A Random Forest model was trained on public ATFCM notification messages to predict the amount of ATFCM regulations over different European air sectors for varying prediction horizons. In addition to the predictive model, in this paper a new way to estimate the maximum prediction horizon is proposed. Using the Hurst exponent, the time-scale at which random behaviour is initiated is found. Comparison of the proposed method with the prediction horizon obtained from the largest Lyapunov exponent indicates that the method is a valid technique for estimating the prediction horizon. By extending the prediction horizon of the model, it is found that the proposed method can reasonably estimate the prediction horizon above which prediction accuracy starts to degrade.
Enhance Latency-Constrained Computation in MEC Networks Using Uplink NOMA

Non-orthogonal multiple access (NOMA) based mobile edge computing (MEC) networks can enhance delay-constrained computation. Most of the existing works focus on the energy or delay minimization, and the study on NOMA based MEC in terms of successful computation probability has been limited, which motivates this work. In particular, randomly deployed edge computing users are modeled as the homogeneous Poisson Point Process and are divided into two groups namely center group (C-group) and edge group (E-group) for uplink NOMA grouping. We propose a new hybrid offloading scheme in a NOMA-based MEC network that can operate in three different modes, namely partial offloading, complete local computation, and complete offloading. We firstly consider a NOMA grouping scenario where a user from the C-group and a user from the E-group are each given a fixed location. The probability that the computation can be completed within the given delay budget is derived and the optimal parameters, i.e., the time for offloading, the power allocation, and the offloading ratios for the two fixed users, are obtained. It reveals that the optimal offloading ratios are determined by the difference of the computational capability between the edge computing user and the MEC server, and that the locations of users have a big impact on the successful computation probability. Inspired by this, we further study three distance-dependent NOMA grouping schemes in the MEC offloading. Specifically, we provide closed-form mathematical expressions of the successful computation probability and its partial optimal solutions for these three schemes. Simulation results verify the accuracy of the analytical results and compare the performance of the proposed offloading scheme with the existing schemes. Insights on the pros and the cons of different user selection schemes are also provided.
Exploring the integration of self-management education in routine care of people with type 2 diabetes mellitus : a qualitative study

2 Acknowledgements . 4 Table of contents . 6 List of tables . 13 List of figures . 15 List of vignettes . 16 List of terms and abbreviations . 17 Chapter
Volunteer Experiences at a Free Clinic in the UnitedStates: A Qualitative Study

Introduction: Free clinics provide an array of medical services at little or no cost to low-income, uninsured individuals in the United States and often rely heavily on volunteers to offer healthcare services for free or at reduced fees. The purpose of this study is to explore volunteering experiences at a community free clinic. Methods: Five focus groups were conducted at a free clinic with volunteers of the clinic (N=28) in September-November in 2016. Thematic analysis was performed to identify themes in issues relating to health, most urgent health issues, and ways to improve services for the underserved populations. Results: Volunteers felt more aware of the experiences of the medically underserved after spending time at the free clinic. Volunteer opportunities such as this could be valuable for those entering the medical profession because of the exposure to an important and overlooked population. Free clinic volunteers need to be able to help in many different areas because of the nature of this type of medical setting. Being properly trained will increase volunteers’ comfort with the clinic and may improve volunteer retention. Connecting with patients and seeing them get their healthcare needs met was listed as one of the most positive parts of the volunteer experience. Discussion: Free clinics allow volunteers to gain educational and professional experiences while assisting in the provision of medical care for underserved populations. It is necessary to develop effective training programs for volunteers in order to maximize the benefits they can bring both to the clinic and the volunteers. Conclusion: Volunteering at free clinics benefits both the community and the volunteers personally as they develop greater understanding of issues facing underserved populations. Since free clinics rely on volunteers, further research on volunteering at free clinics is necessary to improve quality and quantity of free clinic volunteers.
Mesterolone (Proviron) induces low sperm quality with reduction in sex hormone profile in adult male Sprague Dawley rats testis

Anabolic-androgenic steroid compounds are one of the most widely abused drugs by athletes and muscle builders with the goal of improving performance/muscle mass. However, increasing concern has been expressed because these compounds not only offer unappreciable benefits to infertile and subfertile males, but also might have deleterious effects on both human and animal physiology including sperm quality. In addition, there is the conflicting outcome of AAS usage in the clinical settings with its attendant reduced spermatogenesis and hypopituitarism in patient management. Hence, we aim to evaluate the effects of mestorolone, an anabolic-androgenic steroid, on the histomorphometry of seminiferous tubules with serum hormonal and seminal analyses in adult male Sprague-Dawley rat. Twenty adult male Sprague dawley rats divided into two groups of 10 each. The treated group received 0.06 mg/g body weight/ day of mesterolone (proviron) by oral gavage for six weeks while the control group received equal volume of 0.9% normal saline per day. SPSS analysis of data generated with P< 0.05 considered statistically significant. The result showed significant (P< 0.05) body weight gain in all the animals. However, both the raw testicular weight and relative testicular weight per 100 g bwt was significantly (P< 0.05) higher in control than treated. The mean sperm count significantly decreased by 28% (P< 0.05) and the motility reduced significantly by 56% (P< 0.05) in the treated compared to control. In addition, both FSH (follicle stimulating hormone) and T (testosterone) of the treated were significantly lowered by 73% (P< 0.05) and 63% (P< 0.05) respectively compared to the control. The use of mesterolone is with caution and short intermittent therapy is desirous for better semen quality and improved overall fertility.
Significance of obstetric Doppler studies in prediction of perinatal outcome in pregnancy induced hypertension

Background: Pregnancy induced hypertension (PIH) is associated with adverse perinatal outcome. Multi vessel color Doppler studies are useful in these cases for timely intervention. The aim of present study was to know the significance of umbilical, middle cerebral and uterine artery Doppler studies in PIH and to analyse its role in predicting perinatal outcome. Methods: This was a prospective study of 106 singleton pregnancies in the third trimester with PIH. The results of last Doppler ultrasound within one week of delivery were used for analysis. Adverse perinatal outcome was studied in the form of emergency cesarean section for fetal distress, meconium stained amniotic fluid, Apgar at 5 min <7, NICU admission and perinatal mortality (stillbirths and neonatal death). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of various Doppler parameters were calculated after comparing with standard. Results: In the present study specificity and diagnostic accuracy of all Doppler ultrasound parameters was high in predicting adverse perinatal outcome. Cerebroplacental ratio showed highest specificity (98.55%), PPV (94.44%) and diagnostic accuracy (80.19%) in predicting adverse perinatal outcome and it is better than MCA PI and UA PI alone. Uterine artery Doppler evaluation also gives additional information in predicting adverse perinatal outcome. Conclusions: Amongst various Doppler parameters cerebroplacental index (MCA/UA PI) is best predictor of adverse perinatal outcome.
Macronutrients, micronutrients intake and inflammation in hemodialysis patients

Inflammation in hemodialysis patients occurs since before undergoing hemodialysis. Inflammation is associated with an increase in oxidative stress. Hemodialysis patients are at risk for macronutrients and micronutrients deficiencies which can influence the increase in oxidative stress and inflammation. The purpose of this study was to evaluate the intake of micronutrients and inflammatory status in hemodialysis patients. This study was a cross-sectional study with 76 hemodialysis patients (40 male and 36 female) who attended in two hemodialysis centers of Kendal, Indonesia. After obtaining the written consent, then patients were interviewed food intake consisting of macronutrient and micronutrient intake. Macronutrient and micronutrient intake are obtained by the semi quantitative food frequency method and classified as a deficit (<100% adequacy level) and normal/ more (≥100% adequacy level), according to specific recommendations for individuals undergoing dialysis. Serum albumin was examined using the Brom Cresol Purple (BCP) method with a low category (<3.5 mg.dL-1) and normal (3.5 – 4.5 mg.dL-1). The hs-CRP serum was examined using the ELISA method and categorized as low (<1 mg.L-1), moderate (1 – 3 mg.L-1) and high (> 3 mg.L-1). A descriptive analysis was performed. The results of this study showed that 88.2% deficit energy intake, 84.2% deficit protein intake, 85.5% deficit of vitamin A intake, 85.5% deficit of vitamin C intake, 100% deficit of vitamin E intake, 98, 7% deficit zinc intake , 92.1% deficit copper intake. 63.2% subjects are low level of serum albumin and 61.8% subjects is high level of hs-CRP serum. Macronutrient and micronutrient intake in most hemodialysis patients shows deficit. The serum albumin of most hemodialysis patients shows low level. Serum hs-CRP most hemodialysis patients show high level.
Antarctic sea anemone distribution, abundance and relationships with habitat composition, community structure and anthropogenic disturbance

Abstract Understanding the distribution, abundance and habitat preferences of species in the Southern Ocean provides a foundation for assessing the impacts of environmental change and anthropogenic disturbance on Antarctic ecosystems. In near-shore waters at Casey and Davis Stations, photoquadrat surveys were used to determine sea anemone distribution and abundance, habitat preferences, associations with other species and the impact of human disturbance on sea anemone distribution. Two distinct sea anemone morphotypes were found in this study: large sea anemones that require hard substrate for attachment and small, burrowing sea anemones found in muddy sediment. The large sea anemones were found in rocky habitats, with the exception of some sedimentary habitats where other biota were used as substrate. The large sea anemones were associated with a diverse community of epibenthic species found in rocky habitats. The burrowing sea anemones were associated with a less diverse assemblage of sediment-dwelling epibenthos. At Casey Station, sea anemones were more abundant in habitats adjacent to a former waste disposal site than at control sites. The reason for this is not yet known, but may be due to high organic matter inputs or, alternatively, a longer sea ice duration providing protection from ice scour.
Effet de l'inhibition par ARN interférence de la thrombospondine-1 sur la potentialisation de la réponse immune dans un contexte tumoral

Le cancer du sein est actuellement le cancer le plus frequent et le plus mortel chez la femme. Malgre le fait que la prise en charge des patientes ait ete amelioree dans nos societes occidentales au cours des dernieres annees, la principale cause de mortalite reste la dissemination metastatique. Force est de constater que de nombreuses strategies therapeutiques, comme des traitements anti-angiogeniques ou des immunotherapies ciblant des points de controle immunitaire, sont toujours en echec dans ce type de cancer, notamment dans les cancers du sein triple negatifs (TNBC), forme la plus agressive. L'hypoxie tumorale est un facteur de mauvais pronostic car facilitant la dissemination metastatique et inhibant la reponse immunitaire anti-tumorale. Dans ce contexte, la Thrombospondine-1 (TSP1), un anti-angiogene endogene majeur, a ete decrite comme activatrice de TGFs, une cytokine immunosuppressive facilitant la transition epithelio-mesenchymateuse des cellules cancereuses. Nous avons emis l'hypothese que cibler la TSP1 dans les TNBC permettrait non seulement de normaliser l'angiogenese tumorale mais aussi de faciliter la reponse immunitaire. Des analyses de bases de donnees publiques nous ont permis de montrer qu'une forte expression de TSP1 dans les biopsies tumorales est associee a une signature genique d'immunoechappement et a un mauvais pronostic chez les patientes atteintes de TNBC. En accord avec ces observations, nos analyses d'immunohistochimie montrent une correlation inverse entre l'infiltrat tumoral des lymphocytes T CD8+ et l'expression de TSP1 dans des biopsies tumorales de TNBC. Dans un modele preclinique de TNBC, base sur l'injection orthotopique de cellules 4T1, l'inhibition de la TSP1 par interference ARN dans les cellules tumorales (i) augmente significativement le nombre de vaisseaux au sein des tumeurs et l'infiltration intratumorale des lymphocytes, incluant les lymphocytes T CD8, (ii) diminue la dissemination metastatique des 4T1 chez les souris immunocompetentes, mais pas chez les souris Nude, (iii) augmente la reponse aux anti-PD-1. En conclusion, nos resultats montrent que la TSP1, produite par les cellules cancereuses de TNBC, favorise un remodelage vasculaire, inhibe l'infiltration lymphocytaire et facilite la dissemination metastatique. Cibler la TSP-1 permet de reorganiser le microenvironnement tumoral, augmentant la reponse immunitaire anti-tumorale et la reponse aux anti-PD-1. Ainsi, cette etude ouvre vers de nouvelles perspectives therapeutiques chez les patientes atteintes de TNBC et vise a combiner des therapies "anti-anti-angiogeniques" et des immunotherapies comme les anti-PD-1.
EXPLICIT CORPORATE SOCIAL RESPONSIBILITY DISCLOSURE: A TOPIC-BASED APPROACH

In this paper, we investigate whether companies located in liberal market economies report more explicitly about specific CSR topics than firms located in coordinated market economies. For a sample of 3,384 CSR reports of European and US firms, we perform a textual analysis over the period 2008 – 2016. Our results confirm that companies located in LMEs report more explicitly about education and philanthropy; for parental leave and climate, we find a negative and significant association. We also find that CSR performance, size and report length are positively associated with the explicitness of our topic-specific CSR disclosure scores. Our results are robust to a variety of alternative measures.
Comparison between visual and laser-fluorescence diagnosis of occlusal surfaces of first permanent molars. Literature review and clinical cases

Introduction : Proper examination of occlusal surfaces is one of the main objects of scientific interest in dental medicine. A number of diagnostic methods have been established, which purpose is more accurate diagnostics, however, the accurate diagnosis of the occlusal surface of newly erupted first permanent molars is still a challenge for dental specialists. Aim : The aim of this study is to provide information about the application of visual and laser-fluorescence methods for diagnosis of occlusal surfaces of newly erupted first permanent molars and to present personal clinical cases. Materials and methods : Articles in Bulgarian and English language were selected and read in full. We have also conducted our own studies on the application of visual diagnosis and laser-fluorescence diagnosis with Vistacam. 46 newly erupted first permanent molars of 12 children from 5 to 8 years old are monitored. Results : The results of the literature studies confirm Vistacam as a reliable auxiliary diagnostic method, a useful complement to visual diagnostics. Our studies confirm that there is a correlation between the results reported of a diagnosis with Vistacam and visual examination using ICDAS II system. The ICDAS II system used in visual diagnostics is reliable enough, and the application of laser-fluorescence confirms and visualizes the presence or absence of changes in the mineralization of hard dental tissues. Conclusion : The data obtained from literature sources as well as from our own clinical cases will serve as a basis for future studies connected with assessment of occlusal surfaces of newly-erupted first permanent molars before and after silanization, previously diagnosed as sound using both methods.
Customer engagement behaviour on social media platforms: A systematic literature review

Customer engagement behaviours (CEB) on social media have the potential to strengthen relationships between firms and customers. However, there have been no systematic attempts to review the antecedents of CEB on social media despite wide recognition of its importance. Using a systematic literature review method, we provide an in-depth analysis of the extant empirical literature on CEB in relation to social media platforms. Results indicate that there are five key antecedent causes and these are identified in the literature as: (1) social links; (2) ownership-value; (3) search for information; (4) involvement; and (5) functionality. These represent the key antecedents of engagement for firms using social media. Our review is the first to bring together an in-depth secondary data analysis of the antecedents of CEB in social media platforms. We subsequently identify three epistemological tensions within the corpus, and suggest directions for future research in order to advance the understanding of CEB in relation to social media.
Anticorrelation between the Bulk Speed and the Electron Temperature in the Pristine Solar Wind: First Results from the Parker Solar Probe and Comparison with Helios

We discuss the solar wind electron temperatures Te as measured in the nascent solar wind by Parker Solar Probe during its first perihelion pass. The measurements have been obtained by fitting the high-frequency part of quasi-thermal noise spectra recorded by the Radio Frequency Spectrometer. In addition we compare these measurements with those obtained by the electrostatic analyzer discussed in Halekas et al. These first electron observations show an anticorrelation between Te and the wind bulk speed V: this anticorrelation is most likely the remnant of the well-known mapping observed at 1 au and beyond between the fast wind and its coronal hole sources, where electrons are observed to be cooler than in the quiet corona. We also revisit Helios electron temperature measurements and show, for the first time, that an in situ ( ) anticorrelation is well observed at 0.3 au but disappears as the wind expands, evolves, and mixes with different electron temperature gradients for different wind speeds.
H2E: A Privacy Provisioning Framework for Collaborative Filtering Recommender System

— A Recommender System (RS) is the most significant technologies that handle the information overload problem of Retrieval Information by suggesting users with correct and related items. Today, abundant recommender systems have been developed for different fields and we put an effort on collaborative filtering (CF) recommender system. There are several problems in the recommender system such as Cold Start, Synonymy, Shilling Attacks, Privacy, Limited Content Analysis and Overspecialization, Grey Sheep, Sparsity, Scalability and Latency Problem. The current research explored the privacy in CF recommender system and defined the perspective privacy attributes (user's identity, password, address, and postcode/location) which are required to be addressed. Using the base models as Homomorphic and Hash Encryption scheme, we have proposed a hybrid model Homomorphic Hash Encryption (H2E) model that addressed the privacy issues according to defined objectives in the current study. Furthermore, in order to evaluate the privacy level, H2E was implementing in medicine recommender system and compared the consequences with existing state-of-the-art privacy protection mechanisms. It was observed that H2E outperform to other models with respect to determined privacy objectives. Leading to user's privacy, H2E can
A systematic, label-free method for identifying RNA-associated proteins in vivo provides insights into vertebrate ciliary beating

Cell-type specific RNA-associated proteins (RAPs) are essential for development and homeostasis in animals. Despite a massive recent effort to systematically identify RAPs, we currently have few comprehensive rosters of cell-type specific RAPs in vertebrate tissues. Here, we demonstrate the feasibility of determining the RNA-interacting proteome of a defined vertebrate embryonic tissue using DIF-FRAC, a systematic and universal (i.e., label-free) method. Application of DIF-FRAC to cultured tissue explants of Xenopus mucociliary epithelium identified dozens of known RAPs as expected, but also several novel RAPs, including proteins related to assembly of the mitotic spindle and regulation of ciliary beating. In particular, we show that the inner dynein arm tether Cfap44 is an RNA-associated protein that localizes not only to axonemes, but also to liquid-like organelles in the cytoplasm called DynAPs. This result led us to discover that DynAPs are generally enriched for RNA. Together, these data provide a useful resource for a deeper understanding of mucociliary epithelia and demonstrate that DIF-FRAC will be broadly applicable for systematic identification of RAPs from embryonic tissues.
Healthful Eating, the Western Style Diet and Chronic Disease

The term “Western-style diet” refers to an eating pattern that includes a high content of saturated fat, a large amount of processed carbohydrate and too many calories. In common usage, the term Western style diet is pejorative; it connotes a pattern of eating which is essentially unhealthy. Consumption of the Western style diet is strongly linked with the growing epidemic of obesity in the United States and throughout the Western World [1,2]. It is associated with numerous chronic age-related ailments. Among these are cancer (especially colon and breast), cardiovascular diseases and metabolic diseases (metabolic syndrome, type II diabetes and in the liver, specifically, non-alcoholic fatty liver disease (NAFLD). Associations with osteoporosis, chronic kidney disease, earlyonset dementia and skin diseases have also been suggested [3-10]. Once largely confined to societies in North America, Europe and Australia, the Western style diet is now a world-wide phenomenon.