Miracle-dz/UniFAR-FTUs huggingface dataset:
HYBRID APPROACH FOR DATA PUBLISHING USING PRIVACY PRESERVATION TECHNIQUES

Now a day’s governmental and nongovernmental organization wants to share their information for the purpose of knowledge discovery. When the data’s are shared individuals personal data or sensitive data which should not be known to others. Eg. Medical record, voters list, census data. This may leads a latest research field called Privacy preserving data mining. To address these issues, released datasets must be modified to preserve privacy. This article proposes hiding sensitive medical information by using first randomizes the original data and then applying k-anonymity method for sensitive data for preserving the privacy. Here Data fly algorithm is used to implement k-anonymity to anonymize the medical dataset for research purpose.
Interventions for perinatal hypoxic-ischemic encephalopathy.

To the Editor. The review by Drs Vannucci and Perlman on hypoxic-ischemic encephalopathy in newborn infants is outstanding, both in its discussion of mechanisms and its review of potential therapies.1 The commentary provided by Dr Lucey, the editor of Pediatrics, reflects his long-standing leadership on important issues involving neonatal care.2 Neonatal caregivers and families with affected infants would want agencies accountable for studying hypoxic-ischemic encephalopathy in newborn infants, and politicians responsible for resource allocation, to heed the prescription proposed by Dr Lucey. The goals of …
Anaemia in the hydrallazine-induced Lupus syndrome.

A N A E MI A is a common manifestation of the hydrallazine-induced Lupus syndrome (1). Four processes are described in the literature as occurring in the syndrome which might be a cause of the anaemia. These are: (a) haemolysis (2); (b) the formation of a circulating anticoagulant (3); (c) thrombocytopenia (1); and (d) vasculitis. Haemolysis and the formation of a circulating anticoagulant have both been documented and held responsible for anaemia in individual patients with the syndrome. Thrombocytopenia, although described in the syndrome, has not been linked with an anaemia. Vasculitis is assumed to be the cause of anaemia in some patients-but there are no reports of patients having been extensively investigated for confirmation of this.
Final Report : Team 2 Predicting Golden Globe Awards & Christmas Day Movie Gross

Our challenge is focused on making two predictions that revolve around the outcome of movies for the current year 2014. The first challenge is to predict the nominees and award winners for the 72nd Golden Globe Awards taking place on January 11th, 2015. We will focus our efforts to predict the winners of the following four categories: Best Director, Best Actor Motion Picture Drama, Best Actress Motion Picture Drama and Best Screenplay. The second challenge is to predict how much the movies running in theaters on Christmas Day will gross. We consider only the prerelease data associated wih movies to predict the gross of the movies. While both the Golden Globes and Box office gross revolve around the success of the film industry, the two metrics that assess a movies success are very different from each other. Our final report that follows will outline or split approach to handling the two challenges.
A robust method for inter-marker whole slide registration of digital pathology images using lines based features

An automated image registration method is proposed for registration of digital whole slide scans of adjacent tissue sections. An example workflow is where a pathologist annotates a tumor region in a primary (H&E1) stained image and the corresponding regions, in nearby sections, stained with other biomarkers, are identified and analyzed for aiding in clinical diagnosis. The different markers convey different clinical information leading to a more comprehensive analysis. This registration process, if done manually, is tedious and time-consuming. We propose a two-pass algorithm. A lines-based approach, computed from tissue boundary regions, returns the global transformation. Then normalized correlation, based on gradient magnitude images, is used for more precise local matching in a multi-resolution approach. The algorithm is robust to flips, large rotation angles, tissue wear-and-tear, and Area of Interest (AOI2) mismatch, and outperforms state-of-the-art registration methods for digital pathology images.
Vanilloids and the overactive bladder

Currently, the term `overactive bladder' is used as a common denominator for detrusor hyper-re ̄exia, detrusor instability and the urgency/frequency syndrome [1]. Although facilitating the prescription of drugs and the clinical description of the condition, the term `overactive bladder' has further complicated the already confusing scienti®c terminology. This term might suggest that there is only one underlying mechanism for the different conditions, while this is clearly not true (Table 1) [2]. The urodynamic diagnosis of detrusor hyper-re ̄exia is usually straightforward and reproducible, but the diagnosis of detrusor instability remains enigmatic. The pharmacological management of the overactive bladder is multimodal and different targets may be in ̄uenced [3]. Current drugs have been developed to control the function of the efferent nerves, the neuromuscular junction or smooth muscle tone. Anticholinergics such as propantheline, oxybutynin and tolterodine are currently the main drugs used to treat the overactive bladder. They are effective, despite their bothersome sideeffects, e.g. dry mouth, constipation, visual disturbances and cognitive dysfunction. The understanding provided by the changes in bladder innervation after spinal cord injury lead to the discovery of the clinical importance of a C-®bre-mediated sacral re ̄ex arc, sensitive to vanilloids such as capsaicin and resiniferatoxin [4]. Fowler et al. [5] ®rst reported the use of intravesical capsaicin in treating bladder hyperre ̄exia. This report opened the way for the clinical application of drugs designed to alter the function of the C-®bre afferent nerves, thus abolishing a spinal re ̄ex arc.
Hierarchical Feature-Based Volume Morphing

Morphing techniques have been applied to many fields to create astounding visual effects. In this paper, we present a hierarchical feature-based volume morphing algorithm, which leverages the idea of feature-element hierarchy to significantly improve morphing effects. A new type of feature element, the cylinder field, is also given to facilitate the task of feature specification and correspondence. Additionally, with a slight modification, the proposed algorithm can be applied to volume animation.
Execution Replay and Debugging of Distributed Multi-threaded Parallel Programs

Clusters of shared-memory symmetric multiprocessors are increasingly used for high performance computing. To exploit in a convenient way both the inner parallelism of nodes and the parallelism between nodes, programming models for communicating threads are being developed. However, most of these models result in programs exhibiting non-deterministic behavior. This makes cyclic debugging of programs impossible, unless an efficient execution replay system can be provided. This article describes such an execution replay system for distributed thread programming combining synchronization primitives for threads sharing the same node, with communication primitives for threads of different nodes. The execution replay system combines the most efficient trace size reduction technique for shared memory, based on the use of logical clocks, with a very efficient compression technique for trace data that originates from the test functions used in non-blocking communications.
High-throughput genotyping on archived dried blood spot samples.

AIMS The aim of this study was to investigate if dried blood spot (DBS) samples stored in the Danish Neonatal Screening Biobank (DNSB) and the Danish National Birth Cohort (DNBC) repository are useful for Illumina single-nucleotide polymorphism (SNP) genotyping. Genomic DNA (gDNA) was extracted from just one 3.2 mm DBS punch. The extract was subsequently whole-genome amplified to meet the required amounts of DNA for genotyping. For evaluation of the biobank samples, we included variable factors: time of storage, gDNA, and whole-genome amplified DNA (wgaDNA) concentrations and the Illumina quality metric (GenCall score). RESULTS The custom 1152 SNP genotyping assay had a 68.5% locus success rate, which was close to the expected 70%. An effect of storage condition was seen in the DNSB samples stored from 1982 to 1987, whereas none was seen in the samples stored from 1988 to 1990. The genotyping quality of the DNBC samples was affected by type of filter paper. CONCLUSION We here demonstrate that high-throughput Illumina genotyping can be performed successfully on wgaDNA made of gDNA extracted from only one 3.2 mm DBS disk. This validates the vast potential of existing biobanks in the study of the role of gene interactions in complex diseases.
Human hepatitis B virus X protein augments the DNA binding of nuclear factor for IL‐6 through its basic‐leucine zipper domain

The X gene product of human hepatitis B virus, HBx, transactivates the expression of viral and cellular genes through a wide variety of cis elements, including the nuclear factor for IL‐6 (NF‐IL6) binding sites, although HBx does not appear to bind DNA directly. We previously reported that HBx transactivated the interleukin 8 promoter through NF‐κB binding site and C/EBP‐like binding site (NF‐IL6 binding site). In this study, the interactions were examined between NF‐IL6 and HBx using recombinant proteins. In a DNA‐protein binding assay, the formation of a specific complex between NF‐IL6 and a DNA probe harboring an NF‐IL6 binding site was increased by the addition of either the full or the C‐terminal 104 amino acids of HBx. A direct protein‐protein binding assay (far‐Western blot) revealed the direct interaction between the C‐terminal 104 amino acids of HBx and the basic region‐leucine zipper domain of NF‐IL6. These results indicate that HBx alters the DNA‐binding affinity of NF‐IL6 through the direct interaction between the C‐terminal domain of HBx and the basic region‐leucine zipper domain of NF‐IL6. J. Med. Virol. 58:11–18, 1999. © 1999 Wiley‐Liss, Inc.
Optical spectroscopy of a two-dimensional electron gas near the metal-insulator transition.

We report on optical measurements of a two-dimensional electron gas near the metal-insulator transition. We observe the appearance of excitons and negatively charged excitons, ${X}^{\ensuremath{-}}$, at the onset of the transition. The fact that these excitons appear at a relatively large average electron density shows that transition is induced by localization of single electrons in the electrostatic potential fluctuations of the remote ionized donors.
Prevalence, Predictors, and Outcomes of Conservative Medical Management in Non-ST-Segment Elevation Acute Coronary Syndromes in Gulf RACE-2

We assessed the prevalence, predictors, and in-hospital and long-term outcomes of conservative medical management for patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) compared with percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG). This prospective study conducted from October 2008 to June 2009 in 65 hospitals from 6 Arabian Gulf countries included 30-day and 1-year mortality follow-up for 3661 patients. Compared with conservative management group (2859 patients; 78.1%), the PCI group (638; 17.4%) had significantly better unadjusted and adjusted in-hospital (odds ratio [OR]: 0.40, 95% confidence interval [CI]: 0.17-0.97), 30-day (OR: 0.44, 95% CI: 0.24-0.76) and 1-year (OR: 0.58, 95% CI: 0.40-0.87) mortality rates. Comparison with the CABG group (164; 4.5%) yielded similar results with inclusion of patients scheduled for CABG after hospital discharge. Independent predictors of conservative medical management were mainly country of residence and history of prior CABG.
Design of irregular LDPC codec on a single chip FPGA

A novel implementation of irregular low density parity check (LDPC) codec on a single chip Xilinx FPGA is presented in this paper. The encoder and decoder are accomplished by partial parallel architectures with very low complexity. Specifically, details including the decoder and encoder structures, memory management, and required computation units to realize the variable/check node decoding and the parity-check bits generation are discussed. It is verified that the error-correcting capability of the codes with the proposed scheme is kept the same as that by random generation method, while highly parallel encoding/decoding scheme may be realized with ease. Thereby, the proposed design approach for the complex LDPC codec is very promising for real applications.
Comparative analysis of chronic hemorrhoids surgical treatment

The problem of hemorrhoids treatment has been important for more then two thousand years. After the standard closed hemmorroidectomy in the postoperative period pain syndrome long-term rehabilitation of patients, a large number of relapses, can be observed. Implementation method of rubber band ligation, as well as the trans anal doppler-guided hemorrhoidal artery ligation, are an alternative to hemorrhoidectomy in patients with hemorrhoids stage III. The analysis of treatment result was in 75 patients with chronic hemorrhoids treated at proctologic ward in the station Vitebsk (since 2008 II Vitebsk Regional Clinical Hospital) from 2002 to 2009. Accordiny to method of treatment for chronic hemorrhoids three groups of patients. Application were distinguished of trans-anal disarterization of internal hemorrhoids under doppler control with mucopexy and lifting and rubber band ligation gives positive results. In reduction of patients disability from 18,4 ± 0,5 days to 1,3 ± 0,3 days (p < 0,05) rehabilitation of the patients on faster than rehabilitation after using traditional techniques.
The role of type-specific antibodies in colonization and infection by Helicobacter pylori

Purpose of review Helicobacter pylori is a Gram-negative spiral bacterium that colonizes the stomach of humans, causing gastritis, peptic ulcer disease, or gastric cancer. H. pylori infection accounts for a high percentage of mortality and morbidity rates in developing as well as developed countries. H. pylori bacteria reside in the mucus layer covering the gastric epithelium, and therefore the type of protective measures that could confer resistance appear to be limited. Although H. pylori infection stimulates strong local and systemic specific IgA and IgG antibody production, the influence of antibodies on bacterial colonization and gastric inflammation is still controversial. Recent findings Recent studies in experimental animal models have indicated a non-essential role of specific antibodies for host resistance against H. pylori infection. Recent data show that protection is mediated by T cells, CD4 T helper type 1 cells, in particular. Antibodies are not only dispensable for protection, but they impair both the elimination of bacteria and the development of gastritis. This effect appears to be IgA-dependent and is not a function of specific IgM or IgG antibodies. Summary This review highlights the recent advances in our understanding of how antibodies may influence the development of gastric inflammation and bacterial colonization. Such information can significantly increase our basic knowledge of immune regulation and protection against H. pylori infection, but can also indicate new strategies for vaccine development.
[Prevalence of community-acquired methicillin-résistant Staphylococcus aureus].

OBJECTIVE The authors had for aim to assess the prevalence of community-acquired methicillin-resistant Staphylococcus aureus in France. METHOD Two hundred fifty-four strains identified in 1,079 nasal samples from voluntary individuals were analyzed in 2002. An antibiogram (especially measuring the inhibition diameter of cefoxitine) and screening by oxacillin (6 mug/ml) allowed the identification of strains resistant to betalactams. The resistant phenotype was confirmed by amplification of the mecA gene by PCR. The distribution of strains was compared to the resistance to various antibiotics and especially to cotrimoxazole, macrolides, aminosides, and the mechanisms of resistance were determined. RESULTS Eleven methicillin-resistant strains were detected in 254 carriers (4.33%), or 1% of the total population studied. CONCLUSION Complementary tests (detection of the Panton-Valentine toxin, pulsed field electrophoresis) will be necessary to finish strain characterization. It can already be stated that compared to previous studies, community-acquired MRSA carriage is weak in France.
The importance of IL-6 protein expression in primary human renal cell carcinoma: an immunohistochemical study

Aims—Interleukin 6 (IL-6) is produced by some renal carcinoma cell lines in vitro. This might be biologically important because IL-6 is a cytokine of particular interest, owing to its involvement in the growth of renal cell carcinoma. In this study, the expression of IL-6 protein in tissue samples from primary renal cell carcinoma was analysed, and then its clinical importance was examined. Methods—The distribution of IL-6 in renal cell carcinoma was examined by means of an immunohistochemical method in 47 untreated primary renal cell carcinoma samples. The search for a significant difference between histological patterns, Furhman's grading system, TNM classification, and IL-6 protein expression was carried out. Results—Immunohistochemistry demonstrated that IL-6 is expressed in 70% of primary tumours. There was no significant difference in the tumour size and grade between renal cell carcinomas with or without IL-6 expression. However, a relatively large number of high grade tumours expressed IL-6. Conclusion—The importance of IL-6 expression with regard to tumour size/local growth is questionable because IL-6 has been correlated with the development of metastatic disease. These data suggest that the production of IL-6 could exert a growth inhibitory effect on primary renal cell carcinoma.
The adjustment system of phase difference using neural oscillator network for a snake-like robot

Robot are expect to be new tools for the operations and observations in the extreme environments where human has difficulties for accessing directly, deep ocean, space, nuclear plants and so on. One of the important matters to realize mobile robots for extreme environments are to establish systems in the movement and their structures which are strong enough to disturbance. A solution for realization an adaptive control system is to learn and imitate biological systems. For example, in the spinal cord of animals, neural oscillator systems called Central Pattern Generator (CPG) are proven to exist and investigated that CPG control rhythmical signals such as swimming pattern, walking locomotion, heart beats, etc. In this paper, an adaptive control system based on the feature of neural oscillators was developed and applied to motion control of a snake-like robot.
Control of vortex rings for manoeuvrability

Manoeuvrability is critical to the success of many species. Selective forces acting over millions of years have resulted in a range of capabilities currently unmatched by machines. Thus, understanding animal control of fluids for manoeuvring has both biological and engineering applications. Within inertial fluid regimes, propulsion involves the formation and interaction of vortices to generate thrust. We use both volumetric and planar imaging techniques to quantify how jellyfish (Aurelia aurita) modulate vortex rings during turning behaviour. Our results show that these animals distort individual vortex rings during turns to alter the force balance across the animal, primarily through kinematic modulation of the bell margin. We find that only a portion of the vortex ring separates from the body during turns, which may increase torque. Using a fluorescent actin staining method, we demonstrate the presence of radial muscle fibres lining the bell along the margin. The presence of radial muscles provides a mechanistic explanation for the ability of scyphomedusae to alter their bell kinematics to generate non-symmetric thrust for manoeuvring. These results illustrate the advantage of combining imaging methods and provide new insights into the modulation and control of vorticity for low-speed animal manoeuvring.
Contribution a l'etude de l'intersection de surfaces gauches

Ce memoire est une contribution a l'etude de l'intersection de surfaces b-splines ou nurbs. Apres avoir rappele brievement la definition et quelques proprietes des courbes et surfaces b-splines ou nurbs, nous presentons une analyse de differentes methodes d'intersection (subdivision recursive, suivi de contours et methodes mixtes). Nous exposons ensuite la methode que nous avons developpee. L'utilisation de proprietes specifiques a ce type de modelisation nous permet de proposer une technique de localisation autre que la methode de subdivision recursive habituellement utilisee. Une etude des normales aux surfaces permet ensuite de decomposer l'intersection suivant son type (point, courbe, partie d'une surface) afin d'utiliser une methode de determination fiable et adaptee. Puis, le cas de l'intersection surface-plan est aborde. La prise en compte de simplifications permet de mettre en uvre une methode propre a ce cas particulier d'intersection surface-surface. Enfin, nous terminons par une analyse du cout temporel des deux methodes sur des exemples choisis en fonction de leur specificite par rapport au cadre de notre etude. Cette analyse permet de montrer l'importance de chacune des phases en fonction du type d'intersection calcule
A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome.

BACKGROUND Irritable bowel syndrome (IBS) is a common gastrointestinal disorder seen in primary care practice. The symptoms of IBS, including abdominal pain, discomfort, and abnormal bowel function, may be modulated by activity of the serotonin type 3 receptor (5-HT(3)). The efficacy and tolerability of the 5-HT(3) receptor antagonist alosetron hydrochloride in nonconstipated female patients with IBS were evaluated in a double-blind, randomized, placebo-controlled trial. METHODS Patients received either 1 mg of alosetron hydrochloride (n = 309) or placebo (n = 317) twice daily for 12 weeks, followed by a 4-week posttreatment period. Adequate relief of IBS pain and discomfort was the primary end point. Secondary end points included improvements in urgency, stool frequency, stool consistency, incomplete evacuation, and bloating. RESULTS Seventy-one percent of patients were classified as having diarrhea-predominant IBS. Forty-three percent of alosetron-treated patients with diarrhea-predominant IBS reported adequate relief for all 3 months compared with 26% of placebo-treated patients (P<.001; percentage point difference = 17; 95% confidence interval, 8.0-25.4). Improvement with alosetron compared with placebo was observed by the end of the fourth week of treatment and persisted throughout the remainder of treatment. Alosetron significantly decreased urgency and stool frequency and caused firmer stools within 1 week of starting treatment. Effects were sustained throughout treatment and symptoms returned following treatment cessation. No significant improvement in the percentage of days with sense of incomplete evacuation or bloating was observed compared with placebo during the first month of treatment. Constipation was the most commonly reported adverse event. CONCLUSION Alosetron hydrochloride, 1 mg twice daily for 12 weeks, is effective in relieving pain and some bowel-related symptoms in diarrhea-predominant female patients with IBS.