Miracle-dz/UniFAR-FTUs huggingface dataset:
A recursively partitioned mixture model for clustering time-course gene expression data.

BACKGROUND Longitudinally collected gene expression data provides an opportunity to investigate the dynamic behavior of gene expression and is crucial for establishing causal links between changes on a molecular level and disease development and progression. In terms of the analysis of such data, clustering of subjects based on time-course expression data may improve our understanding of temporal expression patterns that result in disease phenotypes. Although there are numerous existing methods for clustering subjects using gene expression data, most are not suitable when expression measurements are repeatedly collected over a time-course. METHODS We present a modified version of the recursively partitioned mixture model (RPMM) for clustering subjects based on longitudinally collected gene expression data. In the proposed time-course RPMM (TC-RPMM), subjects are clustered on the basis of their temporal profiles of gene expression using a mixture of mixed effects models framework. This framework captures changes in gene expression over time and models the autocorrelation between repeated gene expression measurements for the same subject. We assessed the performance of TC-RPMM using extensive simulation studies and a dataset from a multi-center research study of inflammation and response to injury (www.gluegrant.org), which consisted of time-course gene expression data for 140 subjects. RESULTS Our simulation studies encompassed several different scenarios and were aimed at assessing the ability of TC-RPMM to correctly recover true class memberships when the expression trajectories that characterized those classes differed. Overall, our simulation studies revealed favorable performance of TC-RPMM compared to competing approaches, however clustering performance was observed to be highly dependent on the proportion of class discriminating genes used in clustering analysis. When applied to real epidemiologic data with repeated-measures, longitudinal gene expression measurements, TC-RPMM identified clusters that had strong biological and clinical significance. CONCLUSIONS Methods for clustering subjects based on temporal gene expression profiles is a high priority for molecular biology and bioinformatics research. Along these lines, the proposed TC-RPMM represents a promising new approach for analyzing time-course gene expression data.
The Effectiveness of Dynamic Features of Finger Based Gestures on Smartphones' Touchscreens for User Identification

This paper presents methodology for user identification on smartphone and mini-tablet using finger based gestures. In this paper, a set of four features, namely Signature Precision (SP), Finger Pressure (FP), Movement Time (MT), and Speed were extracted from each gesture of eight using dynamic time warping and Euclidean distance. The features are then used individually and combined for the purpose of user identification based on the Euclidean distance and the k-nearest neighbour classifier. We concluded that the best identification accuracy results from the combinations of FP and MT features where 78.46% and 78.33% were achieved on small smartphone and Mini-tablet respectively using a dataset of 50 users.
Neurochemical and behavioral evidence that Ro 41-9067 is a selective presynaptic dopamine receptor agonist.

(-)-2,3,4a,5,6,10b-Hexahydro-7-hydroxy-2-methylbenzo(f)-quinoline 4(1H)-ethanol (Ro 41-9067) was compared with apomorphine, 2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo-[4,5-d]-azepine (B-HT 920), lisuride and other dopamine (DA) receptor agonists in a series of tests designed to characterize its pharmacological activity on DA receptors. In vitro binding studies indicated that Ro 41-9067 bound selectively to DA D2 vs. D1 receptors. It also had a moderate affinity for serotonin1A and alpha-2 adrenergic receptors. Ro 41-9067 exhibited a marked agonistic component for the presynaptic DA autoreceptors. Indeed, it caused a dose-related reduction in locomotor activity over a wide dose range and prolonged periods of observation without stimulating locomotor activity, reflecting postsynaptic DA receptor activation, even at the highest doses. Ro 41-9067 inhibited the gamma-butyrolactone-induced increase in I-dopa accumulation in the rat striatum, an effect sensitive to haloperiodol. Ro 41-9067 inhibited K(+)-induced [3H]DA release and significantly reduced the striatal contents of the DA metabolites, dihydroxyphenilacetic acid and homovanillic acid. Furthermore, the compound counteracted stereotyped behavior and locomotor stimulation induced by amphetamine. Finally, Ro 41-9067 did not appear to act on postsynaptic D2 receptors because it, similarly to B-HT 920 but differently from bromocriptine, quinpirole and lisuride, did not change basal or forskolin-stimulated adenylate cyclase activity. Only at very high concentrations Ro 41-9067 increased adenylate cyclase activity, this effect being due to a D1 agonistic component. (ABSTRACT TRUNCATED AT 250 WORDS)
In Vitro Evaluation of the Antiviral Activity of the Synthetic Epigallocatechin Gallate Analog-Epigallocatechin Gallate (EGCG) Palmitate against Porcine Reproductive and Respiratory Syndrome Virus

In this study, epigallocatechin gallate (EGCG) palmitate was synthesized and its anti-porcine reproductive and respiratory syndrome virus (PRRSV) activity was studied. Specifically, EGCG palmitate was evaluated for its ability to inhibit PRRSV infection in MARC-145 cells when administered as pre-, post-, or co-treatment. EGCG and ribavirin were used as controls. The results showed that a 50% cytotoxic concentration (CC50) of EGCG, EGCG palmitate, and ribavirin was achieved at 2,359.71, 431.42, and 94.06 μM, respectively. All three drugs inhibited PRRSV in a dose-dependent manner regardless of the treatment protocol. EGCG palmitate exhibited higher cytotoxicity than EGCG, but lower cytotoxicity than ribavirin. EGCG palmitate anti-PRRSV activity was significantly higher than that of EGCG and ribavirin, both as pre-treatment and post-treatment. Under the former conditions and a tissue culture infectious dose of 10 and 100, the selectivity index (SI) of EGCG palmitate in the inhibition of PRRSV was 3.8 and 2.9 times higher than that of ribavirin when administered as a pre-treatment, while the SI of EGCG palmitate in the inhibition of PRRSV was 3.0 and 1.9 times higher than ribavirin when administered as a post-treatment. Therefore, EGCG palmitate is potentially effective as an anti-PRRSV agent and thus of interest to the pharmaceutical industry.
Diagnosis of the nervous form of maedi-visna infection with a high frequency in sheep in Castilla y León, Spain

Between 1997 and March 2004, the nervous form, or visna, of maedi-visna infection was diagnosed in 71 of 1631 sheep (4·35 per cent) examined in the Castilla y León region of Spain, of which 634 had shown nervous signs. The presence of the virus was confirmed by immunohistochemistry and in some cases by PCR on frozen-thawed or paraffin-embedded tissue samples. The main clinical signs were hindleg ataxia and paresis, but blindness or nystagmus were also observed. Thirty-three of the affected sheep (46·5 per cent) were two years old or younger. The affected sheep showed variable degrees of a non-suppurative meningoencephalitis, and immunohistochemistry identified positive cells in all cases, with no relation to the intensity of the inflammatory lesion.
2017 EACTS Guidelines on perioperative medication in adult cardiac surgery.

diagnostic or therapeutic medical strategies; however, the EACTS Guidelines do not in any way whatsoever override the individual responsi- bility of health professionals to make appropriate and accurate decisions in consideration of each patient’s health condition and, where appropriate and/or necessary, in consultation with that patient and the patient’s care provider. Nor do EACTS Guidelines exempt health professionals from giving full and careful consideration to the relevant ofﬁcial, updated recommendations or guidelines issued by the competent public health authorities, in order to manage each patient’s case in light of the scientiﬁcally accepted data pursuant to their respective ethical and professional obligations. It is also the health professional’s responsibility to verify the applicable rules and regulations relating to drugs and medical devices at the time of prescription.
Dynamic response of Granlund predetection diversity combiners

A new linearized model is developed for the Granlund combiner that is useful in determining the combiner performance with physically realizable filters and with dynamic variations such as rapid fading and burst signals. The model is tailored for use in determining automatic gain control (AGC) stability. The model is also tailored for use in predicting combiner transient phase correction error.
Rapid vacuolar sequestration: the horseweed glyphosate resistance mechanism.

BACKGROUND Glyphosate-resistant (GR) weed species are now found with increasing frequency and threaten the critically important glyphosate weed-management system [corrected]. RESULTS The reported (31)P NMR experiments on glyphosate-sensitive (S) and glyphosate-resistant (R) horseweed, Conyza canadensis (L.) Cronq. , show significantly more accumulation of glyphosate within the R biotype vacuole. CONCLUSIONS Selective sequestration of glyphosate into the vacuole confers the observed horseweed resistance to glyphosate. This observation represents the first clear evidence for the glyphosate resistance mechanism in C. canadensis.
Lake-Level fluctuations at Le Locle, Swiss Jura, from the Younger Dryas to the Mid-Holocene: A high-resolution record of climate oscillations during the final deglaciation

On the basis of a high-resolution (10 cm / 110 years) lacustrine sequence from Le Locle, Swiss Jura, a fine-scale pattern of palaeohydrological changes is reconstructed for the late Younger Dryas (YD) and the early to mid-Holocene period. The late YD is characterized by a general trend of a fall in lake level and a large climatic instability. The early to mid-Holocene period shows a quasi-cyclic pattern of lake-level fluctuations. Large drops in lake level occurred at ca. 11 600-10 200 cal. BP and ca. 8 900-7 700 cal. BP. Each was interrupted by a short-term rise in lake-level and followed by a longer phase of high lake level respectively at ca. 10 200-8 900 cal. BP and ca. 7 700-6 600 cal. BP. The high lake-level periods at le Locle appear to be in phase with cold spells reconstructed in central Europe, in eastern North America and in the Greenland ice-sheet, or with cooling events and salinity anomalies recorded in the North Atlantic zone. They also coincide with rising residual Δ14C values. These data and the Lateglacial oxygen-isotope GISP2 record suggest three successive quasi-cycles of climatic and environmental changes showing strong similarities in their internal structure. These cycles suggest that large-scale climate oscillations developing from the Bolling warming to the mid-Holocene could have been associated with changes in ocean ventilation probably induced by three deglaciation steps. Finally, as a working hypothesis, a re-exami- nation of the YD event is proposed from a Holocene point of view.
BESS / BOA Patient Care Pathways Subacromial shoulder pain

Subacromial shoulder pain is commonly located to the top and lateral side of the shoulder. It is exaggerated by overhead activity and can be associated with night pain. It is usually associated with full passive range of movement of the glenohumeral joint. The pain originates from the subacromial space of the shoulder, an area made up of the rotator cuff tendons and the subacromial bursa. This area is separate to the main glenohumeral joint. Pain from this area is mainly caused by rotator cuff tendinopathy, also referred to as ‘shoulder impingement’. Impingement occurs between the undersurface of the acromion (roof of shoulder) and the rotator cuff tendons. These tendons can be either intact or torn. A number of other terms such as supraspinatus tendinopathy, tendinitis and bursitis are also used across different disciplines but the diagnosis is essentially the same and referred to in this document as rotator cuff tendinopathy/ impingement.
[Association between interleukin-1B polymorphisms and chronic obstructive pulmonary disease: a meta-analysis].

OBJECTIVE To explore the association between the -511C/T, -31T/C and +3954C/T polymorphisms of interleukin-1B (IL-1B) gene and chronic obstructive pulmonary disease (COPD) using the method of meta-analysis. METHODS Comprehensive searches were performed of PubMed, Embase, Ovid, Wanfang and Chinese journal full-text database to retrieve the related case-control studies. The pooled odds ratios were performed respectively for allele comparison, additive genetic model, dominant genetic model and recessive genetic model and subgroup analysis was also performed by ethnicity. RESULTS Seven case-control studies were included for meta-analysis. Pooled analysis showed that neither -511C/T, -31T/C nor +3954 C/T polymorphisms increased the susceptibility to COPD. In the subgroup analysis by ethnicity, significant risks were found in the Caucasian population for -511C/T T allele (OR = 1.76, 95%CI 1.22 - 2.54, P = 0.002), but not in the Asian population (OR = 0.94, 95%CI 0.64 - 1.38, P = 0.736). Significant risks were also found in the Caucasian population for -31T/C C allele (OR = 0.62, 95%CI 0.40 - 0.97, P = 0.035), but not in the Asian population (OR = 1.06, 95%CI 0.89 - 1.26, P = 0.533). CONCLUSIONS IL-1B polymorphisms may play a role in the susceptibility of COPD in an ethnicity-specific manner. In the Caucasian population, the risk of COPD was associated positively with the IL-1B -511C/T T allele and negatively with the IL-1B -31T/C C allele.
High Performance Predictive Current Control for Active Shunt Filters

A discrete-time predictive current controller, for the application of active power filtering, is designed and analyzed in this paper. A modified algorithm of reference current prediction in the conditions of step change in amplitude and/or frequency is proposed. The theoretical analysis and the validity of the proposed method are verified by simulations. Comparison for the 5th and the 7th harmonic current control is made with the results achieved using synchronous PI plus lead compensator
From Ecological Stoichiometry to Biochemical Composition: Variation in N and P Supply Alters Key Biosynthetic Rates in Marine Phytoplankton

One of the major challenges in ecological stoichiometry is to establish how environmental changes in resource availability may affect both the biochemical composition of organisms and the species composition of communities. This is a pressing issue in many coastal waters, where anthropogenic activities have caused large changes in riverine nutrient inputs. Here we investigate variation in the biochemical composition and synthesis of amino acids, fatty acids (FA), and carbohydrates in mixed phytoplankton communities sampled from the North Sea. The communities were cultured in chemostats supplied with different concentrations of dissolved inorganic nitrogen (DIN) and phosphorus (DIP) to establish four different types of resource limitations. Diatoms dominated under N-limited, N+P limited and P-limited conditions. Cyanobacteria became dominant in one of the N-limited chemostats and green algae dominated in the one P-limited chemostat and under light-limited conditions. Changes in nutrient availability directly affected amino acid content, which was lowest under N and N+P limitation, higher under P-limitation and highest when light was the limiting factor. Storage carbohydrate content showed the opposite trend and storage FA content seemed to be co-dependent on community composition. The synthesis of essential amino acids was affected under N and N+P limitation, as the transformation from non-essential to essential amino acids decreased at DIN:DIP ≤ 6. The simple community structure and clearly identifiable nutrient limitations confirm and clarify previous field findings in the North Sea. Our results show that different phytoplankton groups are capable of adapting their key biosynthetic rates and hence their biochemical composition to different degrees when experiencing shifts in nutrient availability. This will have implications for phytoplankton growth, community structure, and the nutritional quality of phytoplankton as food for higher trophic levels.
The Effects of PDFs on the Line-to-Line Voltage and Noise Generated by PWM Inverters

Acoustic noise is a drawback of PulseWidth Modulated (PWM) inverters switching at frequencies within the audible range. This drawback becomes an important concern when the PWM inverter is located in the vicinity of people (e.g., industrial sites, HVAC installations, etc.). Increasing the switching frequency beyond the audible range is a possible solution that unfortunately leads to the derating of the PWM inverter. On the other hand, random PWM techniques are economical alternatives for acoustic noise reduction. To this end, this paper firstly addresses the development of a random space vector PWM algorithm making use of a small number of switching frequencies (i.e., a limited pool). The random PWM algorithm controls the speed of an induction motor (IM) driven under the constant V/Hz principle. Then, this paper compares the impact that different well-known Probability Density Functions (PDFs) assigned to the switching frequencies in the limited pool have upon the line-to-line voltage waveform and acoustic noise. The PDFs are implemented in a TI TMS320C240 fixed-point digital signal processor (DSP) that is used to control a three-phase IM.
Identifying Drug Therapy Problems Through Patient Consultation at Community Pharmacies: A Quality Improvement Project.

OBJECTIVE This study aimed to identify drug therapy problems during patient counseling at prescription pickup in the community pharmacy setting. METHODS This descriptive quality improvement project assessed the number of drug therapy problems identified during patient consultation. Data were collected for 2 months at 6 community pharmacies in Arizona. The criterion for inclusion was any patient new or transferred prescription consultation provided by a pharmacist or pharmacy intern. Three doctor of pharmacy candidates collected data on a standardized form. The percentage and type of drug therapy problems identified during patient consultation were calculated. RESULTS Data collectors counseled patients on 1305 prescriptions, and of those, 29 drug therapy problems (2.2%) were identified after the pharmacists' final check. The most common problems involved patient drug allergy or sensitivity (20.7%). CONCLUSIONS This project suggests that drug therapy problems in a community pharmacy setting can be identified via patient counseling at the time of prescription pickup.
Development of a Plasmid-Mediated Reporter System for In Vivo Monitoring of Gene Expression in the Archaeon Methanosarcina acetivorans

ABSTRACT A plasmid-based gene reporter system has been developed to construct lacZ gene fusions for monitoring intrinsic promoter expression in Methanosarcina acetivorans. Constructs transform with high efficiency that can be readily screened by color selection on plates and exhibit a consistent copy number on different substrates negating the need for gene copy normalization. Expression of the CO dehydrogenase-acetyl coenzyme A synthase promoter fusion to lacZ revealed 18- to 54-fold down-regulation in cells grown on methylotrophic substrates compared with acetate-grown cells, which is up to an order of magnitude greater than the range of regulation previously reported by enzyme activity assays. This system complements and expands the current techniques for studying genetics of the methanosarcinal Archaea by providing a rapid method for monitoring and quantifying gene expression.
Nephrotic Syndrome due to Membranous Nephropathy Associated with Metastatic Prostate Cancer: Rapid Remission after Initial Endocrine Therapy

A case of severe nephrotic syndrome (urinary protein excretion 12.9 g/day) due to membranous nephropathy associated with untreated prostate cancer and multiple bone metastases is described. A combination of initial endocrine treatment and steroid therapy resulted in normalization of prostate-specific antigen levels followed by a rapid decrease of urinary protein excretion within 4 months. No proteinuria was subsequently detected. Seven months after the initiation of therapy, the patient remained well with complete clinical remission from the nephrotic syndrome. This rapid achievement of remission may have been due to tumor shrinkage by androgen ablation in addition to steroid therapy of the membranous nephropathy. The nephrotic syndrome is a rare complication of prostate cancer, and, to the best of our knowledge, no previous cases have been reported of membranous nephropathy as one of the first disease manifestations.
Indigenous and Scientific Knowledge: Some Critical Comments

Dalam artikel ini, penulis bertujuan untuk merangsang terjadinya debat tentang pengetahuan lokal ( indigenous knowledge ) bertitik tolak dari pendapatnya tentang adanya kontradiksi dan kelemahan-kelemahan konseptual dalam banyak tulisan tentang pengetahuan lokal. Pokok permasalahan yang dibahas dalam artikel ini terutama memfokus pada argumen penulis bahwa perbedaan antara pengetahuan lokal dan pengetahuan ilmiah atau Barat dapat menimbulkan masalah bagi mereka yang percaya atas makna penting dari pengetahuan lokal bagi pembangunan. Artikel ini mengkaji beberapa kontradiksi dan ironi yang terdapat dalam upaya memberikan penekanan pada makna penting pengetahuan lokal. Menurut penulis, pembedaan pengetahuan lokal dan pengetahuan Barat sebagai dua tipe pengetahuan merupakan hal yang tidak produktif dalam upaya melibatkan peranan pengetahuan lokal itu dalam pembangunan yang tangguh dan berkelanjutan. Penulis juga mengemukakan bahwa sebenarnya tidak ada sesuatu yang baru tentang retorika dan perwujudan pengetahuan lokal. Ia pun berpendapat bahwa strategi untuk menyusun arsip dan menyebarluaskan pengetahuan lokal itu juga bertentangan dengan konsep dasar dari pengetahuan lokal itu sendiri. Bagian akhir dari artikel ini secara tentantif menelusuri sejumlah kemungkinan dalam mencari jalan ke luar dari dilema ini. Di antaranya adalah melaksanakan preservasi pengetahuan lokal in situ . Upaya ini hanya akan berhasil bila penduduk setempat dapat memperoleh kontrol atas penggunaan lahan dan sumber-sumber daya alamnya.
Pulse-modulated model of testosterone regulation subject to exogenous signals

Dynamical behaviors arising due to continuous exogenous signals in a previously developed pulse-modulated mathematical model of non-basal testosterone regulation in the human male are studied. In the context of endocrine regulation, exogenous signals represent e.g. the drugs used in hormone replacement therapies, the effects due to circadian rhythm, and interactions with other endocrine loops of the organism. The model dynamics are hybrid since the hormone metabolism is suitably captured by a continuous description and the control feedback is implemented in a discrete (i.e. event-based) manner by the hypothalamus of the brain. It is demonstrated that the endocrine loop with an exogenous signal entering the continuous part can be equivalently described by proper modifications in the pulse-modulation functions of the autonomous model. This extends the scope of the autonomous pulse-modulated models of endocrine regulation to a broader class of problems, such as therapy optimization, where an exogenous signal is involved. The cases of constant and harmonic exogenous signals are treated in detail and illustrated by bifurcation analysis.