Miracle-dz/UniFAR-FTUs huggingface dataset:
Thermal Analysis and Optimization of Nano Coated Radiator Tubes Using Computational Fluid Dynamics and Taguchi Method

Automotive heat removal levels are of high importance for maximizing fuel consumption. Current radiator designs are constrained by air-side impedance, and a large front field must meet the cooling requirements. The enormous demand for powerful engines in smaller hood areas has caused a lack of heat dissipation in the vehicle radiators. As a prediction, exceptional radiators are modest enough to understand coolness and demonstrate great sensitivity to cooling capacity. The working parameters of the nano-coated tubes are studied using Computational Fluid Dynamics (CFD) and Taguchi methods in this article. The CFD and Taguchi methods are used for the design of experiments to analyse the impact of nano-coated radiator parameters and the parameters having a significant impact on the efficiency of the radiator. The CFD and Taguchi methodology studies show that all of the above-mentioned parameters contribute equally to the rate of heat transfer, effectiveness, and overall heat transfer coefficient of the nanocoated radiator tubes. Experimental findings are examined to assess the adequacy of the proposed method. In this study, the coolant fluid was transmitted at three different mass flow rates, at three different coating thicknesses, and coated on the top surface of the radiator tubes. Thermal analysis is performed for three temperatures as heat input conditioning for CFD. The most important parameter for nanocoated radiator tubes is the orthogonal array, followed by the Signal-to-Noise Ratio (SNRA) and the variance analysis (ANOVA). A proper orthogonal array is then selected and tests are carried out. The findings of ANOVA showed 95% confidence and were confirmed in the most significant parameters. The optimal values of the parameters are obtained with the help of the graphs.
A checkpoint roadmap for the complex cell division of Apicomplexa parasites

The unusual cell cycles of Apicomplexa parasites are remarkably flexible with the ability to complete cytokinesis and karyokinesis coordinately or postpone cytokinesis for several rounds of chromosome replication are well recognized. Despite this surprising biology, the molecular machinery required to achieve this flexibility is largely unknown. In this study, we provide comprehensive experimental evidence that apicomplexan parasites utilize multiple Cdk-related kinases (Crks) to coordinate cell division. We determined that Toxoplasma gondii encodes seven atypical P-, H-, Y- and L- type cyclins and ten Crks to regulate cellular processes. We generated and analyzed conditional tet-OFF mutants for seven TgCrks and four TgCyclins that are expressed in the tachyzoite stage. These experiments demonstrated that TgCrk1, TgCrk2, TgCrk4 and TgCrk6, were required or essential for tachyzoite growth revealing a remarkable number of Crk factors that are necessary for parasite replication. G1 phase arrest resulted from the loss of cytoplasmic TgCrk2 that interacted with a P-type cyclin demonstrating that an atypical mechanism controls half the T. gondii cell cycle. We showed that T. gondii employs at least three TgCrks to complete mitosis. Novel kinases, TgCrk6 and TgCrk4 were required for spindle function and centrosome duplication, respectively, while TgCrk1 and its partner TgCycL were essential for daughter bud assembly. Intriguingly, mitotic kinases TgCrk4 and TgCrk6 did not interact with any cyclin tested and were instead dynamically expressed during mitosis indicating they may not require a cyclin timing mechanism. Altogether, our findings demonstrate that apicomplexan parasites utilize distinctive and complex mechanisms to coordinate their novel replicative cycles.
Utility of P19 Gene-Silencing Suppressor for High Level Expression of Recombinant Human Therapeutic Proteins in Plant Cells

Corresponding Author: Hamideh Ofoghi Department of Biotechnology, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran. Phone: +98 2156276326-7 E-mail: ofoghi@irost.ir Abstract Background: The potential of plants, as a safe and eukaryotic system, is considered in the production of recombinant therapeutic human protein today; but the expression level of heterologous proteins is limited by the post-transcriptional gene silencing (PTGS) response in this new technology. The use of viral suppressors of gene silencing can prevent PTGS and improve transient expression level of foreign proteins. In this study, we investigated the effect of p19 silencing suppressor on recombinant human nerve growth factor expression in Nicotiana benthamiana. Materials and Methods: The p19 coding region was inserted in the pCAMBIA using NcoI and BstEII recognition sites. Also, the cloned synthesized recombinant human NGF (rhNGF) fragment was cloned directly into PVX vector by ClaI and SalI restriction enzymes. The co-agroinfiltration of rhNGF with p19 viral suppressor of gene silencing was evaluated by dot-blot and SDS-PAGE. The amount of expressed rhNGF protein was calculated by AlphaEaseFC software. Results: Co-agroinfiltration of hNGF with P19 suppressor showed about fortyfold increase (8% total soluble protein (TSP)) when compared to the absence of P19 suppressor (0.2%TSP). Conclusion: The results presented here confirmed that the use of P19 gene silencing suppressor derived from tomato bushy stunt virus (TBSV) could efficiently increase the transient expression of recombinant proteins in Nicotiana benthamiana manifold.
Technological Variables for Decision-making IoT Adoption in Small and Medium Enterprises

The Internet of Things (IoT) is a key technological trend for the digital transformation of organizations, boosting existing information and communication technologies or the deployment of new IoT solutions to improve their business models. Decision-making IoT adoption in small and medium enterprises is a complex task led by the Chief Information Officer (CIO). The deployment of IoT solutions is affected by permanent technological change in the ICT sector. That implies high investment costs by organizations due to the acquisition of technology, maintenance of technology, training of employees for the appropriate use of each technology, and expensive contracts with the Internet of Things providers for the execution of IoT projects. This paper presents four technological variables that affect decision-making IoT adoption in small and medium enterprises based on the Technology-Organization-Environment Model (TOE). The role of the CIO in supporting the digital transformation of SMEs and the complexity of IoT adoption are highlighted.
Career Mentoring and Job Content Plateaus: The Roles of Perceived Organizational Support and Emotional Exhaustion

The study aims to shed light on whether mentoring may help protégés decrease their perception of job content plateaus. Based on the conservation of resources theory, career mentoring could be an effective resource in decreasing job content plateaus and alleviating the resulting emotional exhaustion. The study also proposes that perceived organizational support (POS) can be an organizational resource for protégés, strengthening the effects of career mentoring in addressing the problem of job content plateaus and ensuing emotional exhaustion (via job content plateaus). Two-wave data were collected from a sample of 353 protégés in Germany. Results showed that career mentoring was negatively related to emotional exhaustion through job content plateaus. Moreover, high POS strengthened the effects of career mentoring, directly in dealing with the issue of job content plateaus and indirectly for emotional exhaustion. Important theoretical and practical implications for mentoring and career plateau research are discussed.
Detection of New Mutations in 23S rRNA Gene of Helicobacter Pylori in Gastric Biopsies in Abidjan

Objectives: The purpose of this study is to determine the presence of mutations in 23S rRNA gene, conferring resistance to clarithromycin of Helicobacter pylori from gastric biopsies in Abidjan (Côte d’Ivoire). Place and Duration: Between August 2015 and February 2016, gastric biopsies were collected from adult patients in endoscopy room in Gastroenterology Department of Hospital and University Center of Cocody (Abidjan), then stored. From October to December 2016, laboratory tests were performed in Bacteriology-Virology department, molecular biology platform of Institute Pasteur of Côte d'Ivoire, and sequencing platform at Eurofins (Cochin, France). Methodology: Helicobacter pylori DNA was extracted directly from stored gastric biopsies. Detection of 23S rRNA gene of Helicobacter pylori resistance to clarithromycin was done through conventional PCR and was quantified using a NanoDrop® spectrophotometer, Lite (Thermo Fischer Scientific, USA), followed by sequencing from Eurofins, MWG / operon (Cochin, France). The reference strains used for sequence comparison were selected from NCBI's Genbank's database with the accession number U27270.1. Results: A new unreported T> C substitution was identified at 100% (3/3) at position 2616 (T2616C) compared to the reference strain. Conclusion: The presence of a constant mutation, not yet described in 23S rRNA gene does require monitoring when the frequency of this mutation is probably responsible for future generations of mutant clones.
Practical Meta-Reinforcement Learning of Evolutionary Strategy with Quantum Neural Networks for Stock Trading

We show the practicality of two existing meta-learning algorithms Model- Agnostic Meta-Learning and Fast Context Adaptation Via Meta-learning using an evolutionary strategy for parameter optimization, as well as propose two novel quantum adaptations of those algorithms using continuous quantum neural networks, for learning to trade portfolios of stocks on the stock market. The goal of meta-learning is to train a model on a variety of tasks, such that it can solve new learning tasks using only a small number of training samples. In our classical approach, we trained our meta-learning models on a variety of portfolios that contained 5 randomly sampled Consumer Cyclical stocks from a pool of 60. In our quantum approach, we trained our quantum meta-learning models on a simulated quantum computer with portfolios containing 2 randomly sampled Consumer Cyclical stocks. Our findings suggest that both classical models could learn a new portfolio with 0.01% of the number of training samples to learn the original portfolios and can achieve a comparable performance within 0.1% Return on Investment of the Buy and Hold strategy. We also show that our much smaller quantum meta-learned models with only 60 model parameters and 25 training epochs have a similar learning pattern to our much larger classical meta-learned models that have over 250,000 model parameters and 2500 training epochs. Given these findings, we also discuss the benefits of scaling up our experiments from a simulated quantum computer to a real quantum computer. To the best of our knowledge, we are the first to apply the ideas of both classical meta-learning as well as quantum meta-learning to enhance stock trading.
Influence of Selected Dietary Plant Extracts on Productive, Physiological, and Viral Immunological Response of Broilers

This experiment was implemented to evaluate the influence of 3 plant extracts involving garlic (GC), cinnamon (CN), and black cumin (BC) powders in broiler chicken diet from 1-42 d on productive, physiological, and immunological traits. In total, 240 birds were assigned into 4 groups, each with 3 replicates. In the control group (CO), the chickens were fed with a balanced diet. Experimental groups were composed by supplementing the diet with 4 mg/kg of diet for each GC, CN, and BC. At 3 and 6 weeks, GC, CN, and BC groups achieved higher body weights, weight gains (p≤0.01), and low feed conversion ratio. GC group recorded low feed intake (p≤0.05) compared to the CO and the other groups from 1 day–6 weeks. GC, CN, and BC groups registered high (p≤0.01) PCV value and lower cholesterol and triglycerides concentrations in serum compared to the CO group. Reduction and increase (p≤0.01) in serum glucose and protein for GC and CN, and CN and BC, respectively, were recorded. High levels of triiodothyronine (T3) (p≤0.05) and thyroid-stimulating hormone (TSH) in GC and CN groups and all treated groups had high concentrations of thyroxine (T4) (p≤0.01) compared to the CO group. Moreover, a clear augmentation in serum antibody titer against Newcastle and Gumboro diseases in GC, CN, and BC compared with the CO group was observed. It was concluded that GC, CN, and BC extracts at the present level may be used to enhance the productive, physiological, and viral immunological characteristics of birds.
Ventricular arrhythmia during rehabilitation of cervical spinal cord injury

Abstract Patients with cervical spinal cord injury have a high incidence of cardiac arrhythmias, especially in the first 14 to 30 days after traumatic event (acute phase). Electrophysiological abnormalities described in the acute phase are most often bradycardia, which is spontaneous or triggered by various stimuli. In the chronic phase, varied arrhythmias are described, but ventricular arrhythmias as a result of autonomic dysregulation in chronic SCI are rare and isolated. We present the case of a patient with a C5-C6 incomplete spinal cord injury (ASIA-B grade) in which symptomatic ventricular arrhythmia is described one year after the traumatic event.
Individual shifts toward safety explain age-related foraging distribution in a gregarious shorebird

Although age-related spatial segregation is ubiquitous, the underlying mechanisms are poorly understood. Here, we aim to elucidate the processes behind a previously established age-related foraging distribution of red knots (Calidris canutus canutus) in their main wintering area in West Africa (Banc d’Arguin, Mauritania). Based on 10 years of observations of 1232 uniquely color-ringed individuals of 1 to 18+ years old, we examined whether the observed age-related foraging distribution resulted from 1) spatial differences in mortality or 2) age-related shifts in habitat use. Using multistate capture–recapture modeling, we showed that with age foraging red knots moved away from the shoreline, that is, to areas with fewer surprise attacks by raptors. Considering uncertainties in the subjective gradient in predation danger with increasing distance from shore (as assessed from correlations between vigilance and distance from shore in foraging birds), we applied 2 different danger zone boundaries, at 40 m and 500 m from shore. Between years, red knots had a much higher chance to move from the dangerous nearshore area to the “safe” area beyond (71–78% and 26% for 40-m and 500-m danger zone boundary, respectively), than vice versa (4% and 14%). For neither danger zone boundary value did we find differences in annual mortality for individuals using either dangerous or safe zone, so the move away from the shore with age is attributed to individual careers rather than differential mortality. We argue that longitudinal studies like ours will reveal that ontogenetic shifts in habitat use are more common than so far acknowledged.
Abiotic and biotic drivers of biomass change in a Neotropical forest

Tropical forests play an important role in the global carbon cycle, but the drivers of net forest biomass change (i.e. net carbon sequestration) are poorly understood. Here, we evaluate how abiotic factors (soil conditions and disturbance) and biotic factors (forest structure, diversity and community trait composition) shape three important demographic processes (biomass recruitment, growth and mortality) and how these underlie net biomass change. To test this, we evaluated 9 years of biomass dynamics using 48 1‐ha plots in a Bolivian tropical moist forest, and measured for the most abundant species eight functional traits that are important for plant carbon gain and loss. Demographic processes were related to the abiotic and biotic factors using structural equation models. Variation in net biomass change across plots was mostly due to stand‐level mortality, but mortality itself could not be predicted at this scale. Contrary to expectations, we found that species richness and trait composition – which is an indicator for the mass‐ratio theory – had little effect on the demographic processes. Biomass recruitment (i.e. the biomass growth by recruiting trees) increased with higher resource availability (i.e. water and light) and with high species richness, probably because of increased resource use efficiency. Biomass growth of larger, established trees increased with higher sand content, which may facilitate root growth of larger trees to deeper soil layers. In sum, diversity and mass‐ratio are of limited importance for the productivity of this forest. Instead, in this moist tropical forest with a marked dry season, demographic processes are most strongly determined by soil texture, soil water availability and forest structure. Only by simultaneously evaluating multiple abiotic and biotic drivers of demographic processes, better insights can be gained into mechanisms playing a role in the carbon sequestration potential of tropical forests and natural systems in general.
MANAGER’S LEADERSHIP STYLES AND JOB PERFORMANCE OF COMPANY RANK AND FILE EMPLOYEES

In company management, several leadership styles are inherent and utilised by a manager or a leader. This study assessed the leadership styles of a manufacturing company manager and how the styles of leadership influence rank and file employees’ performance. In particular, it evaluated the manager’s leadership styles as affirmed by the rank and file employees, and how these leadership styles influence the performance of said employees from the viewpoint of work quality, work quantity, job innovativeness, customer service and team spirit. The study was carried out through a descriptive survey research design utilising a standardised survey questionnaire. Findings revealed that the branch Manager highly utilised transactional and transformational leadership styles in managing the manufacturing company. The Laissez-faire leadership style was only moderately utilised while the autocratic leadership was the least utilised style also at the moderate level. These utilised leadership styles manifested strong influence on the performance and productivity of rank and file employees of the manufacturing company under study. Accordingly, the employees exhibited outstanding performance towards the delivery of their works. It is concluded that managing the human capital of any company elicits full utilisation of good leadership styles supportive to the attainment of the company’s set goals and objectives and employees’ desired outputs and productivity. The company under study should continuously utilise and sustain the use of transactional and transformational leadership styles to keep employees’ productive performance, although there is always room for improvement. Other related studies may be pursued considering other variables or attributes of leadership styles not covered in this study. Article visualizations:
Knowledge and Attitudes of Resident Physicians About Adverse Drug Reactions

Amac: DSO, evrensel mesajinda tum saglik hizmeti saglayicilarina, ADR'ler rapor edilerek binlerce hastanin hayatinin kurtarilabilecegini bildirmistir. Bu calismada, universite hastanemizdeki asistan hekimlerin ADR ve farmakovijilans konusundaki bilgi duzeylerini ve tutumlarini degerlendirmeyi amacladik. Yontem: Bu prospektif calisma, Harran Universitesi Hastanesi'nde calismaya katilmayi kabul eden 88 asistan hekim uzerinde 14 sorudan olusan bir anket formuyla gerceklestirildi. Calismaya Harran Universitesi Tip Fakultesi Etik Kurulu onayinin alinmasindan sonra baslandi. Anketin sonuclari SPSS 18.0 paket programi kullanilarak frekans ve yuzde testleri ile degerlendirildi. Bulgular: ADR'lerin kesin tanimi doktorlarin %51,1'i tarafindan dogru bir sekilde isaretlenmistir. Hekimlerin cogu (%69,3) hicbir zaman ADR raporlamasi yapmadigini belirtmistir. ADR raporlamasi yapmanin saglik profesyonellerinin sorumlulugu olmadigini dusunen katilimcilarin orani %9,1'dir. Hekimlerin sadece %6,8'inin ADR raporlamasi hakkinda mesleki bilgi veya egitim aldigi gozlemlenmistir. Hekimlerin %72,7'si Turkiye'de ADR'nin ciddi bir sorun oldugunu dusunmektedir. Sonuc: Bu calisma hastanemizde calisan asistanlarin ADR raporlamasi konusundaki bilgi ve tutum duzeylerinin yeterli olmadigini gostermistir. ADR'lerin raporlanmasi konusunda saglik uzmanlari arasinda farkindaligin artirilmasinin onemli olduguna ve durumun etkili ve periyodik egitim yontemleriyle iyilestirilebilecegine inaniyoruz.
On d*-Complete Topological Spaces and Related Fixed Point Results

In this paper, we introduce the concept of d*-complete topological spaces, which include earlier defined classes of complete metric spaces and quasi b-metric spaces. Further, we prove some fixed point results for mappings defined on d*-complete topological spaces, generalizing earlier results of Tasković, Ćirić and Prešić, Prešić, Bryant, Marjanović, Yen, Caccioppoli, Reich and Bianchini.
Epigenetic regulations by insulin and histone deacetylase inhibitors of the insulin signaling pathway in muscle

Diabetes and insulin resistance are metabolic diseases characterized by altered glucose homeostasis due to defects in insulin secretion, insulin action in peripheral organs, or both. Insulin is the key hormone for glucose utilization and regulates gene expression via transcriptional and epigenetic regulations.We determined the epigenetic implications in the regulation of expression of insulin signaling pathway genes. Hexokinase 2 (HK2) is known to be upregulated by insulin and directs glucose into the glycolytic pathway. In L6 myotubes, we demonstrated that insulin-induced HK2 gene expression rely on epigenetic changes on the HK2 gene, including an increase in histone acetylation around the transcriptional start site (TSS) of the gene and an increase in the incorporation of the histone H2A.Z isoform – a histone variant of transcriptionally active chromatin. Both are epigenetic modifications compatible with increased gene expression.To elucidate the role of histone acetylation in the regulation of insulin signaling and insulin-dependent transcriptional responses in L6 myotubes, we investigated the effects of butyrate, an histone deacetylase inhibitor (HDACi), in a model of insulin resistance induced by lipotoxicity. Butyrate partly alleviated palmitate-induced insulin resistance by ameliorating insulin-induced PKB (protein kinase B) and MAPK (Mitogen-activated protein kinase) phosphorylations, downregulated with exposure to palmitate. Butyrate induced an upregulation of IRS1 gene and protein expression. The transcriptional upregulation of IRS1 was proven to be epigenetically regulated, with butyrate promoting increased histone acetylation around the TSS of the IRS1 gene.These results support the idea of the existence of a link between epigenetic modifications and insulin action. Pharmacological targeting of the epigenetic machinery might be a new approach to improve metabolism, especially in the insulin resistant condition.Key words: Muscle, insulin resistance, epigenetic, chromatin, histone acetylation, histone deacetylase inhibitor (HDACi), butyrate, palmitate