Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulation and Synchronization for Aeronautical Telemetry

Modulation and Synchronization for Aeronautical Telemetry Christopher G. Shaw Department of Electrical and Computer Engineering Doctor of Philosophy Aeronautical telemetry systems have historically been implemented with constant envelope modulations like CPM. Shifts in system constraints including reduced available bandwidth and increased throughput demands have caused many in the field to reevaluate traditional methods and design practices. This work examines the costs and benefits of using APSK for aeronautical telemetry instead of CPM. Variable rate turbo codes are used to improve the power efficiency of 16and 32-APSK. Spectral regrowth in nonlinear power amplifiers when driven by non-constant envelope modulation is also considered. Simulation results show the improved spectral efficiency of this modulation scheme over those currently defined in telemetry standards. Additionally, the impact of transitioning from continuous transmission to burst-mode is considered. Synchronization loops are ineffective in burst-mode communication. Dataaided feedforward algorithms can be used to estimate offsets in carrier phase, frequency, and symbol timing between the transmitter and the receiver. If a data-aided algorithm is used, a portion of the transmitted signal is devoted to a known sequence of pilot symbols. Optimum pilot sequences for the three synchronization parameters are obtained analytically and numerically for different system constraints. The alternating sequence is shown to be optimal given a peak power constraint. Alternatively, synchronization can be accomplished using blind algorithms that do not rely on a priori knowledge of a pilot sequence. If blind algorithms are used, the observation interval can be longer than for data-aided algorithms. There are combinations of pilot sequence length and packet length where data-aided algorithms perform better than blind algorithms and vice versa. The conclusion is that a sequential arrangement of blind algorithms operating over an entire burst performs better than a CRB-achieving data-aided algorithm operating over a short pilot sequence.
Halothane Relaxes Previously Constricted Isolated Porcine Coronary Artery Segments More Than Isoflurane

Coronary vasodilation by halothane and isoflurane were compared using in vitro tension recording. Porcine left anterior descending coronary arterial segments (1.5–2.0 mm o.d.) were constricted with either K+ (30 mM) or prostanoid U44069 (6 x 10−7 M) in the absence of other drugs or anesthetics. Following stabilization of constriction, arteries were exposed to halothane or isoflurane at 0.5, 1.0, 1.5, 2.0, and 3.0% concentrations. K+ (30 mM) induced constriction was reduced by halothane at 1.5, 2.0, and 3.0% and U44069 (6 x 10−7 M) induced constriction was reduced at 0.5, 1.0, 1.5, 2.0, and 3.0%. K+ (30 mM) induced constriction was reduced by isoflurane only at 3.0% and U44069 (6 x 10−7 M) induced constriction was reduced by isoflurane only at 2.0 and 3.0%. U44069 induced constriction was more susceptible than K+ induced constriction to relaxation by halothane or isoflurane. Halothane was more potent than isoflurane as a direct relaxant of porcine epicardial left anterior descending arterial segments previously constricted with K+ (30 mM) or U44069 (6 x 10−7 M).
Human ELG1 Regulates the Level of Ubiquitinated Proliferating Cell Nuclear Antigen (PCNA) through Its Interactions with PCNA and USP1*

The level of monoubiquitinated proliferating cell nuclear antigen (PCNA) is closely linked with DNA damage bypass to protect cells from a high level of mutagenesis. However, it remains unclear how the level of monoubiquitinated PCNA is regulated. Here, we demonstrate that human ELG1 protein, which comprises an alternative replication factor C (RFC) complex and plays an important role in preserving genomic stability, as an interacting partner for the USP1 (ubiquitin-specific protease 1)-UAF1 (USP1-associated factor 1) complex, a deubiquitinating enzyme complex for PCNA and FANCD2. ELG1 protein interacts with PCNAs that are localized at stalled replication forks. ELG1 knockdown specifically resulted in an increase in the level of PCNA monoubiquitination without affecting the level of FANCD2 ubiquitination. It is a novel function of ELG1 distinct from its role as an alternative RFC complex because knockdowns of any other RFC subunits or other alternative RFCs did not affect PCNA monoubiquitination. Lastly, we identified a highly conserved N-terminal domain in ELG1 that was responsible for the USP1-UAF1 interaction as well as the activity to down-regulate PCNA monoubiquitination. Taken together, ELG1 specifically directs USP1-UAF1 complex for PCNA deubiquitination.
Analysis of bidirectional information transfer on drumming ensemble using robotic session system

For the design of artificial systems with the ability to co-create with humans, it is necessary to consider how robots interpret and apply its human partner's actions in its own actions. Nowadays many robots with the ability to co-create with human appeared but few research succeeded in quantifying the interaction between humans and robots, making it difficult to assess the importance of the robot's contribution to the interaction.
Evaluación de la técnica inhalatoria y la adherencia al tratamiento con inhaladores en farmacia comunitaria

Introduccion: La via inhalatoria es de eleccion para la administracion de la mayoria de los farmacos empleados en el tratamiento de las enfermedades pulmonares obstructivas. No obstante, una tecnica inhalatoria incorrecta puede comprometer el control de dichas patologias. Objetivos: El objetivo de este trabajo fue evaluar la tecnica inhalatoria de los pacientes de una farmacia comunitaria y su adherencia al tratamiento. Metodos: Se llevo a cabo un estudio observacional descriptivo transversal con 74 pacientes en tratamiento con inhaladores a los que se les encuesto sobre su tecnica de inhalacion y la adherencia al tratamiento. Ademas, se les solicito una demostracion practica del manejo del inhalador. Resultados: El 47% de los encuestados cometieron errores criticos de uso del inhalador, aunque el 97.3% creian saber utilizarlo correctamente. El error mas frecuente fue no esperar al menos un minuto entre inhalaciones cuando era necesario repetir la dosis. Aunque el 96% de los encuestados refirio haber recibido informacion sobre como utilizar el inhalador, solo en un 1% fue impartida por farmaceuticos. El 47% de los pacientes presento una buena adherencia al tratamiento, pero el 60% presento algun tipo de incumplimiento, siendo el incumplimiento erratico el mas frecuente. Conclusiones: Este estudio demuestra que un elevado porcentaje de pacientes utiliza una tecnica inhalatoria incorrecta y presenta una mala adherencia terapeutica, lo que puede contribuir a una menor efectividad del tratamiento y a un peor control de sus problemas de salud. Es necesario un papel mas activo de los farmaceuticos comunitarios para evitar esta situacion.
Effects of Fan Blade Forward-Swept and Inclined Amounts in Electric Motors

This paper studies the effects of blades' forward-swept amount in the rotation direction and forward-inclined amount in the intake direction on the flow around the fan blades of a large open-type motor. The authors have previously clarified this flow separation on the blade surface under high ventilation resistance from flow analysis and visualization experiments. To prevent flow separation, they proposed forward-swept and inclined blades, together with reduction of the air path's ventilation resistance. In this study, numerical fluid analyses were performed on the flow around forward-swept and inclined blades of axial fans for large open-type motors. Several combinations of forward-swept and inclined amounts were studied. The relationship between forward-swept and inclined amounts and flow was evaluated quantitatively, and an ideal combination was obtained. The study revealed that an axial fan with this combination showed much higher flow rate than a conventional fan without forward-swept and inclined blades. Furthermore, it significantly decreased fluid noise and axis power.
Bladder cancer and smoking in males: Types of cigarettes, age at start, effect of stopping and interaction with occupation

A case‐control study of 512 male cases of bladder cancer and 596 male hospital controls (all living in the province of Turin, Northern Italy) has been analyzed for cigarette smoking. Relative risks (RRs) decreased with years since stopping, whereas they seemed not to change with age starting to smoke. A multiplicative effect of RRs for smoking and high‐risk occupations was suggested. Filters exerted a protective effect (RR = 0.3 for smokers of filter‐tip cigarettes only vs. smokers of non‐filter‐tip cigarettes). A previously unreported difference was noticed between black types and blond types of tobacco (RR = 0.4 for smokers of the blond types only vs. smokers of the black types, adjusted for age, average daily amount, years since stopping, occupation and use of filter).
The effect of HAART on cervical intraepithelial neoplasia in women with HIV : a systematic review

Objectives: to review studies on the effect of antiretroviral therapy on the short term incidence, prevalence, regression, recurrence and the progression rates of pre-malignant conditions of the cervix in women infected with HIV. Outcome measures: the effect of HAART therapy on the incidence, prevalence, regression, progression and recurrence rates of cervical intraepithelial neoclassic. Inclusion criteria: prospective or retrospective studies, either comparative or non-comparative, that present data on regression, progression, recurrence, incidence or prevalence rates of cytologically or histologically diagnosed cervical intraepithelial neoplasia Exclusion criteria: Studies with incomplete data for analysis were excluded Study population: HIV positive women receiving HAART. Comparative groups were: o HIV positive women with cervical intraepithelial neoclassic who had not been commenced on antiretroviral therapy o HIV positive women with cervical intraepithelial neoplasia on any other antiretroviral therapy other than the HAART combinations o HIV negative women with cervical intraepithelial neoplasia Materials and methods: a systematic review of studies with results on the effect of HAART on CIN was conducted. Electronic databases were searched; reference lists of identified studies were searched. Results: Seven studies were included in this review with a total of 1018 HIV infected women. The studies were carried out in three developed countries (America, France and Italy). Two studies assessed the effect of HAART on the prevalence rates of CIN, while the other five evaluated the effect of HAART on the recurrence, progression and regression rates of CIN. One study found a statistically significant decrease in prevalence rates with HAART use. One study showed a non-statistically significant decrease in the prevalence rates with HAART use. Three studies showed increased rates of regression rates with HAART use, one study showed that regression rates were comparable in all the groups and while one showed statistically significant increase in progression rates with HAART use. Conclusions: The question of the effect of HAART on CIN has not been adequately addressed by the studies in this review. The current recommendations of close cervical cancer screening surveillance in women infected with HIV should still be followed even in women on HAART until there is enough evidence to suggest otherwise. There is still a need to conduct large multicentre trials to address this question.
Mitomycin C in Filtering Surgery for Primary Congenital Glaucoma: A Comparison of Exposure Durations.

PURPOSE To compare the effect of two exposure durations of mitomycin C in combined angle and filtering surgery for primary congenital glaucoma. METHODS This was a prospective study conducted in the Department of Ophthalmology at Alexandria Main University Hospital, Alexandria, Egypt, on 75 eyes with primary congenital glaucoma that underwent combined trabeculotomy-trabeculectomy with intraoperative mitomycin C application for 1 minute (MMC 1) or 2 minutes (MMC 2) and were followed up for 24 months. Success rates were studied and complications noted. Success was defined by a composite primary end point of an intraocular pressure (IOP) of less than 16 mm Hg under general anesthesia, without any IOP-lowering medications and with no hypotony-related complications and/or lack of IOP-related progression of the disease as evidenced by worsening of the ocular biometric characteristics. RESULTS The mean age of the study participants was 6.7 ± 4.1 months (range: 2 to 16 months; median: 6 months) in the MMC 1 group (35 eyes) and 7.7 ± 5.7 months (range: 1 to 32 months; median: 6.5 months) in the MMC 2 group (40 eyes). The initial surgery was successful in 32 (91.5%) and 31 (77.5%) eyes in the MMC 1 and MMC 2 groups, respectively. The mean IOP was 18.4 ± 5.1 and 18.1 ± 6.1 mm Hg preoperatively and 5.5 ± 3.5 and 4.8 ± 2.8 mm Hg at the end of follow-up in the MMC 1 and MMC 2 groups, respectively. There was no statistically significant difference in the clinical parameters between the two groups. Complications included cataracts in each group and hypotony optic disc edema in 3 eyes (7.5%) in the MMC 2 group. CONCLUSIONS Both mitomycin C application durations were effective in combined trabeculotomy-trabeculectomy with mitomycin C for primary congenital glaucoma. The longer duration was not advantageous in disease control and there were no significant differences in complications. [J Pediatr Ophthalmol Strabismus. 2018;55(3):164-170. ].
Microparticles variability in fresh frozen plasma: preparation protocol and storage time effects.

BACKGROUND Extracellular vesicles or microparticles exhibiting procoagulant and thrombogenic activity may contribute to the haemostatic potential of fresh frozen plasma. MATERIALS AND METHODS Fresh frozen plasma was prepared from platelet-rich plasma at 20 °C (Group-1 donors) or directly from whole blood at 4 °C (Group-2 donors). Each unit was aseptically divided into three parts, stored frozen for specific periods of time, and analysed by flow cytometry for procoagulant activity immediately after thaw or following post-thaw storage for 24 h at 4 °C. Donors' haematologic, biochemical and life-style profiles as well as circulating microparticles were analysed in parallel. RESULTS Circulating microparticles exhibited a considerable interdonor but not intergroup variation. Fresh frozen plasma units were enriched in microparticles compared to plasma in vivo. Duration of storage significantly affected platelet- and red cell-derived microparticles. Fresh frozen plasma prepared directly from whole blood contained more residual platelets and more platelet-derived microparticles compared to fresh frozen plasma prepared from platelet-rich plasma. Consequently, there was a statistically significant difference in total, platelet- and red cell-derived microparticles between the two preparation protocols over storage time in the freezer. Preservation of the thawed units for 24 h at 4 °C did not significantly alter microparticle accumulation. Microparticle accumulation and anti-oxidant capacity of fresh frozen plasma was positively or negatively correlated, respectively, with the level of circulating microparticles in individual donors. DISCUSSION The preparation protocol and the duration of storage in the freezer, independently and in combination, influenced the accumulation of microparticles in fresh frozen plasma units. In contrast, storage of thawed units for 24 h at 4 °C had no significant effect on the concentration of microparticles.
Antibodies to high-density lipoprotein and beta2-glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary antiphospholipid syndrome.

OBJECTIVE To determine the prevalence of anti-high-density lipoprotein (anti-HDL) antibodies and to establish a possible relationship between anti-HDL, anticardiolipin antibodies (aCL), anti-beta(2)-glycoprotein I (anti-beta(2)GPI), and paraoxonase (PON) activity in patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). METHODS Thirty-two patients with SLE and 36 with primary APS were enrolled in a cross-sectional study. Twenty age- and sex-matched healthy subjects were used as controls. Serum levels of IgG and IgM aCL, anti-beta(2)GPI, and antiprothrombin antibodies and IgG anti-HDL were measured by enzyme-linked immunosorbent assay. Total cholesterol, HDL cholesterol, HDL(2), and HDL(3) were determined by standard enzymatic techniques. PON activity was assessed by quantification of nitrophenol formation, and total antioxidant capacity (TAC) by chemiluminescence. RESULTS Levels of total HDL, HDL(2), and HDL(3) were reduced in patients with SLE compared with controls (mean +/- SD 0.51 +/- 0.3, 0.37 +/- 0.3, and 0.14 +/- 0.1 mmoles/liter, respectively, versus 1.42 +/- 0.9, 1.01 +/- 0.7, and 0.40 +/- 0.2). Patients with SLE and primary APS had higher titers of anti-HDL antibodies and lower PON activity than controls. In the SLE population, PON activity was inversely correlated with IgG anti-HDL titers (r = -0.48, P = 0.005) whereas in the primary APS population, IgG anti-beta(2)GPI was the only independent predictor of PON activity (r = -0.483, P = 0.003). In the SLE group, anti-HDL was inversely correlated with TAC (r = -0.40, P < 0.02), and PON activity was positively correlated with TAC (r = 0.43, P < 0.02). CONCLUSION IgG anti-HDL and IgG anti-beta(2)GPI antibodies are associated with reduced PON activity in patients with SLE and primary APS. Since the physiologic role of PON is to prevent low-density lipoprotein oxidation with its attendant atherogenic effects, the reported interactions may be relevant to the development of atherosclerosis in SLE and primary APS.
The Respiratory Syncytial Virus Fusion Protein and Neutrophils Mediate the Airway Mucin Response to Pathogenic Respiratory Syncytial Virus Infection

ABSTRACT Respiratory syncytial virus (RSV) is the leading cause of death due to a viral etiology in infants. RSV disease is characterized by epithelial desquamation, neutrophilic bronchiolitis and pneumonia, and obstructive pulmonary mucus. It has been shown that infection of BALB/cJ mice with RSV clinical isolate A2001/2-20 (2-20) results in a higher early viral load, greater airway necrosis, and higher levels of interleukin-13 (IL-13) and airway mucin expression than infection with RSV laboratory strain A2. We hypothesized that the fusion (F) protein of RSV 2-20 is a mucus-inducing viral factor. In vitro, the fusion activity of 2-20 F but not that of A2 F was enhanced by expression of RSV G. We generated a recombinant F-chimeric RSV by replacing the F gene of A2 with the F gene of 2-20, generating A2–2-20F. Similar to the results obtained with the parent 2-20 strain, infection of BALB/cJ mice with A2–2-20F resulted in a higher early viral load and higher levels of subsequent pulmonary mucin expression than infection with the A2 strain. A2–2-20F infection induced greater necrotic airway damage and neutrophil infiltration than A2 infection. We hypothesized that the neutrophil response to A2–2-20F infection is involved in mucin expression. Antibody-mediated depletion of neutrophils in RSV-infected mice resulted in lower tumor necrosis factor alpha levels, fewer IL-13-expressing CD4 T cells, and less airway mucin production in the lung. Our data are consistent with a model in which the F and attachment (G) glycoprotein functional interaction leads to enhanced fusion and F is a key factor in airway epithelium infection, pathogenesis, and subsequent airway mucin expression.
Psychological empowerment as a strategy for personnel retention in the oilfield service industry

The intellectual gap experienced by the oil and gas industry has created a hyper competitive environment forcing organizations to look for ways to retain their best talents beyond the traditional benefit offerings. This paper examines if components of psychological empowerment contribute to employee retention. To examine this, a survey was administered to 37 oilfield service personnel from different companies in Malaysia. The results indicate that psychological empowerment components of role ambiguity, span of control, sociopolitical support, access to information, access to resources, and participative unit climate encourage employee retention suggesting that retention programs which are cognitive in nature can yield intended result.
Power Measurement Setup for On-Wafer Large Signal Characterization Up to Q-Band

We report on the development of a nonlinear vector network analyzer power measurement setup for on-wafer large signal device characterization up to the Q-band. The setup can be used with various types of load pull (active, passive or hybrid) and enables measurements both in continuous wave and pulsed modes (1- $\mu \text{s}$ pulsewidth and a duty cycle of 1%). Subsequently, state-of-the-art power results at 40 GHz have been achieved on sub-10 nm barrier AlN/GaN high electron mobility transistors. Pulsed load-pull measurements allowed reaching an output power density at such high frequency above 6 W/mm together with high efficiency up to a drain voltage of 30 V while avoiding self-heating effects and thus gate leakage current degradation.
[Delayed hypersensitivity reactions in patients bearing malignant brain tumors with human tumor cell lines grown in vitro].

Human neoplastic cells grown in vitro from brain tumors behave as strrig antigens; these antigens may be used for detecting the cell-bound immunity of patients bearing malignant tumors. I t is suggested that this crossed immunity is related with a common tumor antigen linked with the transplantation associated tumor antigen, but different. The delayed hypersensitivity reaction could thus br used for the diagnosis of thc, iicciplastic disease as the tuberculiti test for tuberculosis, but is of no value for prognosis and rvoliitioti. These results should be repeated on a large scale: isolatiwi of the antigen and clinical e.rpprimpiitritioti are in prnci.s. s.
A feedback based rate control algorithm for multicast transmitted video conferencing^{1}

This paper presents a feedback based rate control algorithm for video conferencing on the Internet. This algorithm adaptively controls the transmission rate of a video stream, which is being multicast to a heterogeneous group of receivers. The fact that the sender is transmitting a single video stream to many receivers introduces a number of issues. These issues include the variable nature of the available network resources and the fact that there is no easy way to determine the availability of these resources. In addition, even if we were able to track closely the changing network conditions, the best transmission rate for the aggregate means a trade off between high and low end receivers. The algorithm presented in this paper, called the Target Bandwidth Rate Control Algorithm, dynamically controls the output rate of the video coder by receiving and processing bandwidth levels from each receiver in the videoconference. The goal of this algorithm is to maximize the aggregate amount of video displayable at the receivers. This algorithm also allows us to limit the worst case loss experienced by the low-end receivers. In addition to considering the available network bandwidth in the feedback information, this algorithm allows for workstation and user requirements to be considered when determining the senders output rate. In order to show the effectiveness of this approach, we first analyze the algorithms performance in a simulation environment. In this set of tests we study the effects of different configurations of receivers in terms of the number of receivers and availability of resources. Additionally, we have implemented this algorithm in the VIC video conferencing system in order to analyze its effectiveness under real network conditions.