Miracle-dz/UniFAR-FTUs huggingface dataset:
Propuesta metodológica para determinar el costo final de un medicamento intrahospitalario

Objective : To design a methodology to assess the impact of processes in the value chain of costs billed to third-party payors for drugs with greater participation in the total turnover of a health institution. Methodology : It was based on the theory of value chain, defined by Michael Porter. To this effect, by analyzing information reported by the health service provider institution (IPS), a first documentary stage established the drugs with greater participation in billing, through the Pareto principle. Results : Based on the analysis of the processes in the value chain of hospital drugs, a formula was proposed to identify those with the most influence on the final cost. Conclusions : Based on the analysis of all processes in the value chain, this methodologically sound formula constitutes a tool that allows to take actions for a continuous improvement, leading to cost reduction and the generation of added value.
Biochemical‐genetic variation in a wild and a cultured population of the greenshell mussel, Perna canaliculus

Abstract A wild and a cultured greenshell mussel (Perna canaliculus) population were compared for biochemical genetic variation at seven polymorphic and four monomorphic allozyme loci. Significant heterozygote deficiencies were observed for all polymorphic loci (La—1, La—2, Lap, Lgg—1, Lgg— 2, Pgi, and Pgm) for both populations (except the Pgi locus of the wild mussel population). Genotypic disequilibrium was calculated for both populations: genotypic frequencies were significantly non‐random at three pairs of loci among the wild mussels, and significantly non‐random at three different pairs of loci among the cultured mussels. All six pairs of loci which exhibited significant genotypic disequilibrium involved amino‐peptidases, suggesting that these loci form a linkage group, and that neither the Pgi nor the Pgm loci are associated with this group. Exact tests for population differentiation based upon population‐specific allele distributions indicated that four of the polymorphic loci were significantly he.
Real-Time Support During a Logistic Process Using Smart Gloves

Optimizing logistic processes and digitizing them is one of the goals of Industry 4.0. Many of the existing processes are paper-based and cannot be completely automated. From our industrial partners we know that the presence of humans is still required in processes where flexibility and adaptability is necessary. Technologies such as smart textiles in combination with wearables can support and digitize such semi-automated processes. We have investigated the use of smart gloves to reengineer an existing commissioning process that currently uses a handheld scanner. This paper describes two prototypes to explore different textile designs in combination with wearables. We conducted a user study with 27 participants to evaluate a commissioning process from a German truck manufacturer. 59 % of the participants preferred the Two Gloves design and 41 % the One Glove design over the current process based on the handheld scanner.
Review on the Geographic and Elevational Distribution of the Mountain Long-Eared Bat Plecotus Macrobullaris, Completed by Utilising a Specific Mist-Netting Technique

The mountain long-eared bat, Plecotus macrobullaris, is a recently described species, and characterisation of its geographic and elevational distribution is still in progress. Captures in various environments led to a controversial ecological perception, with P. macrobullaris initially defined as an alpine species but subsequently found in the Mediterranean seashore and other lowland areas. Sampling efforts hitherto were uneven; this bat has been studied more thoroughly in Western Europe than in the eastern portion of its range, and in lowlands more than highlands or alpine environments. For greater insight into its distribution pattern, we conducted a field survey in several mountain areas of its known range, using a novel mist-netting technique (described herein) that has proven very useful for targeting and capturing low-flying open-space bats in alpine environments. We also gathered all available distribution data on this species from published resources and by contacting researchers, obtaining records at 351 total localities (including 113 from other authors' unpublished reports and 45 from our own fieldwork). We concluded that P. macrobullaris is present in the main Western Palearctic mountain ranges, extending from the Pyrenees to the Middle East, and has an elevational distribution from sea level up to 2,800 m. The high number of these bats captured foraging above the timberline, in addition to the exclusively mountainous distribution, indicate that the species is indeed alpine, showing a pattern similar to other highly mobile vertebrates restricted to mountain areas and absent from flatlands. Nevertheless, its apparent elevational distribution may still be biased toward lower areas, due to the scarcity of surveys in high mountain habitats.
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder

Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms which may also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process. We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune-mediated disease.
Developing and Validating an Item Bank for Alcohol Use Disorder Screening in the Chinese Population by Using the Computerized Adaptive Testing

Objective To detect the individual’s severity of alcohol use disorder (AUD) in an effective and accurate manner, this study aimed to build an item bank for AUD screening and derive the computerized adaptive testing (CAT) version of AUD (CAT-AUD). Methods The initial CAT-AUD item bank was selected from the Chinese version of the questionnaires related to AUD according to the DSM-5 criteria. Then 915 valid Chinese samples, covering the healthy individuals and the AUD high-risk individuals, completed the initial CAT-AUD item bank. By testing the unidimensionality, test fit, item fit, discrimination parameter and differential item functioning of the initial item bank, the final CAT-AUD item bank confirming to the requirements of the item response theory (IRT) were obtained. Subsequently, the CAT-AUD simulation study based on the real data of the final item bank conducted to detect characteristics, reliability, validity, and predictive utility (sensitivity and specificity) of CAT-AUD. Results The CAT-AUD item bank meeting the IRT psychometric measurement requirements could be well geared into the graded response model. The Pearson’s correlation between the estimated theta via CAT-AUD and the estimated theta via the full-length item bank reached 0.95, and the criterion-related validity was 0.63. CAT-AUD can provide highly reliable test results for subjects whose theta above −0.8 with an average of 16 items. Besides, the predictive utility of CAT-AUD was better than AUDIT and AUDIT-C. Conclusion In brief, the CAT-AUD developed in this study can effectively screen the AUD high-risk group and accurately measure the AUD severity of individuals.
The Psychological Expectation of New Project Income Under the Influence of the Entrepreneur’s Sentiment From the Perspective of Information Asymmetry

The phenomenon of high first-day income and high break-up rate in China’s capital market has long attracted the attention of investors. Based on the disagreement model, in combination with the information asymmetry theory and behavioral finance, a mathematical model was put forward to analyze the reasons and mechanisms for the excess return of the initial public offering (IPO) on the first-day under the influence of investors’ sentiments. The analysis shows that the IPO first-day income is a function of the disagreement between investors, which generally presents an asymmetric U shape. Information asymmetry affects the degree of valuation deviation. The sentiment of investors reflects the psychological state of the investor at the time, which makes the income increase or decrease under the influence of investor sentiment and market sentiment. In turn, it leads to the emergence of excess returns or break-up rates on the first-day. The research results help deepen the understanding of the IPO pricing mechanism and explore the impact of investor psychology on its pricing, putting forward suggestions for the issue pricing mechanism of the Sci-Tech Innovation Board.
Systems Biology Approaches to Understand the Host–Microbiome Interactions in Neurodegenerative Diseases

Neurodegenerative diseases (NDDs) comprise a broad range of progressive neurological disorders with multifactorial etiology contributing to disease pathophysiology. Evidence of the microbiome involvement in the gut-brain axis urges the interest in understanding metabolic interactions between the microbiota and host physiology in NDDs. Systems Biology offers a holistic integrative approach to study the interplay between the different biologic systems as part of a whole, and may elucidate the host–microbiome interactions in NDDs. We reviewed direct and indirect pathways through which the microbiota can modulate the bidirectional communication of the gut-brain axis, and explored the evidence of microbial dysbiosis in Alzheimer’s and Parkinson’s diseases. As the gut microbiota being strongly affected by diet, the potential approaches to targeting the human microbiota through diet for the stimulation of neuroprotective microbial-metabolites secretion were described. We explored the potential of Genome-scale metabolic models (GEMs) to infer microbe-microbe and host-microbe interactions and to identify the microbiome contribution to disease development or prevention. Finally, a systemic approach based on GEMs and ‘omics integration, that would allow the design of sustainable personalized anti-inflammatory diets in NDDs prevention, through the modulation of gut microbiota was described.
The vestibular labyrinth of the albino rat: Form and dimensions, and the orientation of the semicircular canals, cristae, and maculae

Form and dimensions of the osseous labyrinth . Angular measurements of the semicircular canals . The occipital bone . 413 418 420 421 Mutual angular relations of the canals . Method of angular measurements against reference planes . Anterior (superior Posterior canal . Lateral canal . Form and dimensions o Angular relations of the membranous labyrinth Utriculus, and macula utriculi Xacculus, and macula sacculi The cristae . Discussion and summary . 437 Literature cited . 444
The Logic of Interactive Biorobotics

In recent studies, robots are used to stimulate living systems in controlled experimental settings. This research strategy is here called interactive biorobotics, to distinguish it from classical biorobotics, in which robots are used to simulate, rather than to stimulate, living system behavior. This article offers a methodological analysis of interactive biorobotics and has two goals. The first one is to argue that interactive biorobotics is methodologically different, in some important respects, from classical biorobotics and from countless instances of model-based science. It will be shown that interactive biorobotics does not conform to the so-called “understanding by building” approach or synthetic method, and that it illustrates a novel use of models in science. The second goal is to reflect on the logic of interactive biorobotics. A distinction will be made between two classes of studies, which will be called “proximal” and “distal. ” In proximal studies, experiments involving robot-animal interaction are brought to bear on theoretical hypotheses on robot-animal interaction. In distal studies, experiments involving robot-animal interaction are brought to bear on theoretical hypotheses on animal-animal interaction. Distal studies involve logical steps which may be particularly hard to justify. This distinction, together with a methodological reflection on the relationship between the context in which the experiments are carried out and the context in which the conclusions are expected to hold, will lead to a checklist of questions which may be useful to justify and evaluate the validity of interactive biorobotics studies. The reconstruction of the logic of interactive biorobotics made here, though preliminary, may contribute to justifying the important role that robots, as tool for stimulating living systems, can play in the contemporary life sciences.
A Temporal Sampling Basis for Visual Processing in Developmental Dyslexia

Knowledge of oscillatory entrainment and its fundamental role in cognitive and behavioral processing has increasingly been applied to research in the field of reading and developmental dyslexia. Growing evidence indicates that oscillatory entrainment to theta frequency spoken language in the auditory domain, along with cross-frequency theta-gamma coupling, support phonological processing (i.e., cognitive encoding of linguistic knowledge gathered from speech) which is required for reading. This theory is called the temporal sampling framework (TSF) and can extend to developmental dyslexia, such that inadequate temporal sampling of speech-sounds in people with dyslexia results in poor theta oscillatory entrainment in the auditory domain, and thus a phonological processing deficit which hinders reading ability. We suggest that inadequate theta oscillations in the visual domain might account for the many magno-dorsal processing, oculomotor control and visual deficits seen in developmental dyslexia. We propose two possible models of a magno-dorsal visual correlate to the auditory TSF: (1) A direct correlate that involves “bottom-up” magnocellular oscillatory entrainment of the visual domain that occurs when magnocellular populations phase lock to theta frequency fixations during reading and (2) an inverse correlate whereby attending to text triggers “top-down” low gamma signals from higher-order visual processing areas, thereby organizing magnocellular populations to synchronize to a theta frequency to drive the temporal control of oculomotor movements and capturing of letter images at a higher frequency.
Differential Effects of Psychotic Illness on Directed and Random Exploration

Schizophrenia is associated with a number of deficits in decision-making, but the scope, nature, and cause of these deficits are not completely understood. Here we focus on a particular type of decision, known as the explore/exploit dilemma, in which people must choose between exploiting options that yield relatively known rewards and exploring more ambiguous options of uncertain reward probability or magnitude. Previous work has shown that healthy people use two distinct strategies to decide when to explore: directed exploration, which involves choosing options that would reduce uncertainty about the reward values (information seeking), and random exploration (exploring by chance), which describes behavioral variability that is not goal directed. We administered a recently developed gambling task designed to quantify both directed and random exploration to 108 patients with schizophrenia (PSZ) and 33 healthy volunteers (HVs). We found that PSZ patients show reduced directed exploration relative to HVs, but no difference in random exploration. Moreover, patients’ directed exploration behavior clusters into two qualitatively different behavioral phenotypes. In the first phenotype, which accounts for the majority of the patients (79%) and is consistent with previously reported behavior, directed exploration is only marginally (but significantly) reduced, suggesting that these patients can use directed exploration, but at a slightly lower level than community controls. In contrast, the second phenotype, comprising 21% of patients, exhibits a form of “extreme ambiguity aversion,” in which they almost never choose more informative options, even when they are clearly of higher value. Moreover, in PSZ, deficits in directed exploration were related to measures of intellectual function, whereas random exploration was related to positive symptoms. Taken together, our results suggest that schizophrenia has differential effects on directed and random exploration and that investigating the explore/exploit dilemma in psychosis patients may reveal subgroups of patients with qualitatively different patterns of exploration.
Propionate Induces Virulent Properties of Crohn’s Disease-Associated Escherichia coli

Crohn’s disease (CD) is a severe chronic immune-mediated granulomatous inflammatory disease of the gastrointestinal tract. The mechanisms of CD pathogenesis remain obscure. Metagenomic analysis of samples from CD patients revealed that several of them have the elevated level of Escherichia coli with adhesive–invasive phenotype (AIEC). Previously, we isolated an E. coli strain CD isolate ZvL2 from a patient with CD, which features AIEC phenotype. Here, we demonstrate that prolonged growth on propionate containing medium stimulates virulent properties of CD isolate ZvL2, while prolonged growth on glucose reduces these properties to levels indistinguishable from laboratory strain K-12 MG1655. Propionate presence also boosts the ability of CD isolate ZvL2 to penetrate and colonize macrophages. The effect of propionate is reversible, re-passaging of CD isolate on M9 medium supplemented with glucose leads to the loss of its virulent properties. Proteome analysis of CD isolate ZvL2 growth in medium supplemented with propionate or glucose revealed that propionate induces expression porins OmpA and OmpW, transcription factors PhoP and OmpR, and universal stress protein UspE, which were previously found to be important for macrophage colonization by enteropathogenic bacteria.
The role of reinforcement in speciation: Theory and data

▪ Abstract To assess the frequency and importance of reinforcement in nature we must begin by looking for its signature in the most likely places. Theoretical studies can pinpoint conditions that favor and inhibit reinforcement, and empirical studies can identify both how often these conditions occur and whether reinforcement results. We examine how well these tools have addressed these questions by searching for gaps and mismatches in theoretical and empirical studies of reinforcement. We concentrate on five areas: (a) a broad assessment of selection against interspecific mating, (b) the mode and genetic basis of nonrandom mating, (c) the geography of speciation, (d) divergent selection on mating cues, (e) and the genetics of reproductive isolation. We conclude that reinforcement has probably not been looked for where it is most likely to occur. We pinpoint however, many further areas of study that may ultimately provide a strong assessment of the importance of reinforcement in speciation. “The grossest .
Origin and early evolution of chloroplasts

ABSTRACT Photosynthetic organisms have played a significant role as primary producers and ultimate sources of the atmospheric oxygen through geologic time. How they have evolved is one of the key questions in the study of the biological and environmental history of the Earth. Modern algal chloroplasts (plastids) are greatly diversified in morphology and pigmentation. Because the paleontological record can never be complete, a multidisciplinary approach is essential to reveal the pattern, timing, and mechanism of chloroplast evolution. Several independent lines of evidence show that all chloroplasts derived from a single endosymbiotic cyanobacterium and spread in different eukaryotic taxa via multiple secondary endosymbioses. With the advent of the genomic era, comparative genomics has been employed to reveal the course of their evolution. Yet, the study of non-model organisms remains important to understand how today's diverse life has evolved, such as in the case of uniquely pigmented prochlorophytes. Paleontological records may provide constraints on the timing of the primary and secondary endosymbiotic events.
A data-based mathematical modelling study to quantify the effects of ciprofloxacin and ampicillin on the within-host dynamics of Salmonella enterica during treatment and relapse

Antibiotic therapy has drastically reduced the mortality and sequelae of bacterial infections. From naturally occurring to chemically synthesized, different classes of antibiotics have been successfully used without detailed knowledge of how they affect bacterial dynamics in vivo. However, a proportion of patients receiving antimicrobial therapy develop recrudescent infections post-treatment. Relapsing infections are attributable to incomplete clearance of bacterial populations following antibiotic administration; the metabolic profile of this antibiotic-recalcitrant bacterial subpopulation, the spatio-temporal context of its emergence and the variance of antibiotic–bacterial interactions in vivo remain unclear. Here, we develop and apply a mechanistic mathematical model to data from a study comparing the effects of ciprofloxacin and ampicillin on the within-host dynamics of Salmonella enterica serovar Typhimurium in murine infections. Using the inferential capacity of our model, we show that the antibiotic-recalcitrant bacteria following ampicillin, but not ciprofloxacin, treatment belong to a non-replicating phenotype. Aligning with previous studies, we independently estimate that the lymphoid tissues and spleen are important reservoirs of non-replicating bacteria. Finally, we predict that post-treatment, the progenitors of the non-growing and growing bacterial populations replicate and die at different rates. Ultimately, the liver, spleen and mesenteric lymph nodes are all repopulated by progenitors of the previously non-growing phenotype in ampicillin-treated mice.