Miracle-dz/UniFAR-FTUs huggingface dataset:
Développement de formulations polymériques de S-nitrosoglutathion comme traitement per os pour prévenir les maladies inflammatoires chroniques de l’intestin

Les maladies inflammatoires chroniques de l’intestin (MICI) representent un probleme de sante publique majeur touchant de jeunes patients. Aux recidives inflammatoires, a la mauvaise qualite de vie et a l’esperance de vie reduite des patients viennent s’ajouter la duree, l’efficacite parfois limitee et le cout des traitements actuellement proposes. La recherche de nouvelles strategies permettant de prevenir les recidives inflammatoires est primordiale. Ainsi, le role du S-nitrosoglutathion (GSNO, donneur et forme de stockage naturelle de NO) dans le maintien de l’integrite de la barriere intestinale est etudie dans cette these, en decrivant : i) l’effet concentration-dependante du GSNO sur la permeabilite intestinale (modele de chambre de Ussing, expression des proteines de jonctions cellulaires…), ii) des formulations innovantes de GSNO (nanoparticules composites) a base de nanoparticules d’Eudragit®RL, elles-memes encapsulees dans une matrice polymerique a base d’alginate. Differents procedes de formulation ont ete testes. Une caracterisation physicochimique des objets developpes et des etudes de permeabilite sur des modeles cellulaires (Caco-2) ont conduit a l’obtention de trois formulations, adaptees a la voie orale et permettant de delivrer de facon prolongee le GSNO. Cependant, la prise en charge du GSNO libre ou formule, l’identification des cibles du NO au niveau intestinal, mais aussi les doses et durees du traitement in vivo restent encore a definir avant de proposer ce donneur de NO comme candidat pour un traitement preventif des MICI
MANAGEMENT OF STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis(TEN) represent a spectrum of the same disease caused by drugs in almost all cases. Early referral and supportive care in a specialised unit reduce mortality. The article discusses important management principles when caring for SJS/TEN patients. 1a
Vitamin E as an in Vitro and in Vivo Antioxidant a

alpha-Tocopherol has near optimal activity as a chain-breaking antioxidant. Inherent antioxidant activity plays an important part in determining overall biological activity but the phytyl tail also exerts a very important influence. The new deuterated alpha-tocopherol/GC-MS technique is providing unprecedented insight into the importance of the stereochemistry of the phytyl tail in determining bioavailability, as well as helping to discover how rapidly and effectively absorption, transport, uptake, and loss occur. Measurements of rate of turnover in tissues indicate that differences exist between different types of animals. It is possible that these tissue differences may explain the diverse range of vitamin E deficiency symptoms observed across a wide variety of animals. It is not known what is responsible for the differences in biokinetic behavior.
Instrumentalne imenske skupine sa značenjem sredstva i načina

The paper analyzes instrumental noun phrases, which are, in most Croatian grammars, defined as an indirect object or, more frequently, as an adverbial, with no clear criteria for distinguishing them. In this paper, as well as in many other papers (Ivić 1954, Kamp and Rossdeutscher 1994, Alexiadou and Schafer 2006, Levin and Rappaport 1988, Ono 1992, Levin 1993, Van Valin and LaPolla 1997, Van Valin 2005, Belaj and Tanacković Faletar 2017), we distinguish a) an instru ment causer, which occupies the central position in the causal chain, in which the Agent occupies the first position and the Patient the last position, and b) an in strument that is not a part of the causal chain. In this paper, the instrumental noun phrases are divided into non-obligatory instrumental complements – instrument causer – and adjuncts – facilitating instrument and manner. Facilitating instru ment is a transitional category between instrument causer and manner, and some times it is difficult to determine whether it belongs to one of these two categories.
Stability of networked control system with bandwidth limitation and Bernoulli-process packet loss in feed-back

In this paper, mean-square stabilization of the LTI systems with feed-back through digital communication channel is studied. According to the quantization and packet loss over the digital channel, the networked control system is stabilized by a linear matrix inequality (LMI) based controller, with which searching for the coarsest quantization density is converted to feasibility problems. The trade-off between quantization density and packet loss rate that ensures system stabilizable is discussed and the design method of the controller is given. Based on the controller, a necessary condition for the upper bound of the truncation to practically stabilize the system with digital feed-back is developed. A numerical example demonstrates the algorithm working on a system over digital channel feed-back.
Juncture detection 1

The ‘units-of-perception' hypothesis has led psycholinguists to concern themselves with units o f classification rather than with the more important process o f speech segmentation. This paper argues that segmentation rather than classification o f the speech signal is the primary prelexical process in speech perception. We claim further that universal juncture detection processes alone can account fo r processing differences between French and English which might be otherwise taken as evidence that different secondarylevel perceptual units are involved in the perception o f different languages.
INFLUENCE OF THE PRETRANSPLANT HEMATOCRIT LEVEL ON EARLY GRAFT FUNCTION IN PRIMARY CADAVERIC RENAL TRANSPLANTATION

Although use of human recombinant erythropoietin has alleviated symptoms of anemia in renal failure, effects of increased hematocrit (HCT) on early post-transplant renal function are unknown. Of 244 consecutive primary cadaveric kidney recipients transplanted over 74 months, 43% had HCT ≥ 30% and 57% had HCT < 30% at transplantation. The incidence of delayed graft function (DGF) was greater in recipients with HCT ≥ 30% (61%) than in recipients with HCT < 30% (33%; P=0.0001). Ten percent of recipients with HCT ≥ 30% experienced primary nonfunction (PNF) of the allograft (P=0.0001). No recipient with HCT < 30% had PNF. Absolute rises in HCT over the 3 months preceding transplantation were greatest in those with PNF (2.5± 2.4) followed by those with DGF (2.0±3.1) and immediate graft function (IGF) (0.215.2; P=0.0328). Logistic regression analysis identified HCT ≥ 30% (P=0.0014), cold storage ≥ 24 hr (P=0.0006) and rising HCT (P=0.0090) as independent predictors of DGF with relative risks of 3.1-, 3.3-, and 2.7-fold, respectively. Recipients with rising pretransplant HCTs who underwent dialytic fluid removal within 24 hr before transplantation had DGF with greater frequency (67%) than non-dialyzed recipients with rising HCTs (45%). Primary cadaveric kidney recipients with HCT ≥ 30% at transplantation have significantly greater risk for DGF and PNF. Rising pretransplant HCT levels may predispose recipients to DGF; this risk may be heightened in those undergoing hemodialysis shortly before transplantation.
Trust path: a distributed model of search paths of trust in a peer-to-peer system

Trust management is not an easy task in a peer-to-peer system because a peer is not able to know all the other peers in the system, and therefore, it is not obvious to exchange documents safely. Accordingly, an efficient model of trust management is necessary to manage the trust between peers in order to, quickly and efficiently, make the difference between potentially malicious and benevolent peers before downloading a document. Several approaches have been developed to calculate the indirect trust value. These approaches are based on sequential search of trust paths. In this paper and in order to optimize the research response time of trust paths, we propose a new distributed model called Trust_Path to search all trust paths between two peers that have no direct knowledge. This search is performed by propagation, in a distributed manner, to all known peers. The experiments realized on a network of 16 servers, on which we have set up virtual machines, show that the response time of search of trust paths with the parallel execution using Trust_Path model is much faster than sequential execution and that its acceleration increases according to the number of nodes. The simulation results show that our model can be applied to a large-scale environment.Copyright © 2014 John Wiley & Sons, Ltd.
Adherence to medical treatment in relation to pregnancy, birth outcome & breastfeeding behavior among women with Crohn's disease.

BACKGROUND Crohn's disease (CD) is common among women of fertile age, and it often requires maintenance medical treatment. Adherence to medical treatment among women with CD prior to, during, and after pregnancy has, however, never been examined. Although CD women have increased risk of adverse pregnancy outcomes, little is known about predictors for these outcomes in women with CD. In addition, the impact of breastfeeding on disease activity remains controversial. AIMS The aims of this PhD thesis were to determine adherence to treatment and to investigate predictors for and prevalence rates of non-adherence to maintenance medical treatment among women with CD prior to, during, and after pregnancy; to assess pregnancy outcomes among women with CD, taking medical treatment, smoking status, and disease activity into account; to assess breastfeeding rates and the impact of breastfeeding on the risk of relapse. METHODS We conducted a population-based prevalence study including 154 women with CD who had given birth within a six-year period. We combined questionnaire data, data from medical records, and medical register data. RESULTS Among 105 (80%) respondents, more than half reported taking medication with an overall high adherence rate of 69.8%. Counselling, previous pregnancy, and planned pregnancy seemed to decrease the likelihood of non-adherence, whereas smoking seemed to predict non-adherence prior to pregnancy, although our sample size prevented any firm conclusions. During pregnancy, the vast majority (95%) of CD women were in remission. The children's birth weight did not differ in relation to maternal medical treatment, but mean birth weight in children of smokers in medical treatment was 274 g lower than that of children of non-smokers in medical treatment. In our relatively small study CD women in medical treatment were not at increased risk of adverse pregnancy outcomes compared with untreated women with CD. In total, 87.6% of CD women were breastfeeding, and rates did not vary by medical treatment. Smoking and non-adherence seemed to predict relapse in CD during the postpartum period, whereas breastfeeding seemed protective against relapse. CONCLUSIONS Although we generally had low statistical precision this thesis suggests that counselling regarding medical treatment may be an important factor for medical adherence among CD women of fertile age. In addition CD women in medical treatment did not seem at increased risk of adverse pregnancy outcome, but smoking predicted lower birth weight. Breastfeeding did not seem to increase the risk of relapse in CD.
A DSP-based implementation of a new nonlinear control for a three-phase neutral point clamped boost rectifier prototype

This work presents the design and implementation of a nonlinear control strategy for a three-phase three-level neutral-point-clamped boost rectifier. The adopted control consists of nonlinear feedback linearization technique. The nonlinear state-space model of the rectifier was obtained in the dq0 reference frame. The input/output feedback linearization is then applied and the linearizing control law is derived. Therefore, the resulting model is linearized and decoupled in three independent subsystems. Afterwards, the stabilizing controllers are designed based on linear techniques to control line currents, output, and neutral point voltages. The control law is designed using Simulink/Matlab and applied to the converter via a 1.8-kHz pulsewidth modulator (PWM). Both control law and PWM signals are executed in real time using the DS1104 DSP of dSPACE. A 1.2 kW laboratory prototype is built for validation purposes. The proposed control law robustness is validated for diverse severe load and system parameter variations. It shows robust performance in terms of high power factor, low total harmonic distortion and output voltage ripples, small overshoot, and short settling time.
Design of Truncated Maximum Length Ternary Signals Where Their Squared Versions Have Uniform Even Harmonics

The design of pseudo-random maximum length (PRML) ternary signals with properties suitable for identification of generalized quadratic Hammerstein models is considered. For such an application, it is desirable for the signal to have odd harmonics uniform and even harmonics suppressed, with its squared version having odd harmonics suppressed and even harmonics uniform. To date, the only class of signal known to possess such harmonic properties comprises of PRML ternary signals based on Galois field GF(3), and its extension fields. In this note, theoretical conditions for a PRML signal to possess these properties are derived and imposed on the design of signals based on higher odd fields to generate truncated PRML signals that fulfil the required specifications
Si-Based Hybrid Microcooler With Multiple Drainage Microtrenches for High Heat Flux Cooling

Microfluid cooling solution is one of the most effective techniques for thermal management of high heat fluxes. A jet-based Si microcooler with multiple drainage microtrenches (MDMTs) has been developed for microelectronic thermal management. Integrated with MDMT in hybrid microcooler, the negative cross-flow effect between nearby nozzles is eliminated, and thus fully developed jet impingement can be enabled for each nozzle. An inlet/outlet flow arrangement layer has been introduced to achieve uniform pressure distribution. The effects of three types of arrangement structures on the hydraulic and thermal performance of microcooler have been analyzed and compared. Two different thermal/fluid simulation models have been constructed for microcooler design. The test vehicle with the new nozzle/trench layer is fabricated using double-side deep reactive-ion etching process. Assembly of the stacked microcooler and Si thermal test chip is finished through two-steps optimized thermal compression bonding process. With 0.05-W pumping power for the microcooler, the heat dissipation of 260 W/cm2 has been demonstrated, and the chip temperature can be maintained under 51 °C. Excellent agreement has been obtained between experimental and simulation results. With the MDMT, enhanced-microjet array impinging has been achieved, and uniform chip temperature distribution is obtained.
Practical Next Bit Test for Evaluating Pseudorandom Sequences

Abstract In this paper, we use both the stochastic dynamic programming and Bayesian inferences concepts to design an optimum-acceptance-sampling-plan policy in quality control environments. To determine the optimum policy we employ a combination of costs and risk functions in the objective function. Unlike previous studies, accepting or rejecting a batch are directly included in the action space of the proposed dynamic programming model. Using the posterior probability of the batch to be in state p (the probability of non-conforming products), first we formulate the problem into a stochastic dynamic programming model. Then, we derive some properties for the optimal value of the objective function, which enable us to search for the optimal policy that minimizes the ratio of the total discounted system cost to the discounted system correct choice probability.
Effect of urine pH, storage time, and temperature on stability of catecholamines, cortisol, and creatinine.

In studies of stress in humans and animals, urinary excretion of catecholamines and cortisol is widely used as a stress index (1)(2). In most studies that have measured urinary catecholamines, hydrochloric acid or some antioxidant has been added to the urine samples immediately after voiding. This is probably because classic methodology demands preservation of urine specimens to prevent catecholamine degradation (3)(4)(5). On the other hand, urine is not usually acidified when glucocorticoids are to be analyzed (2)(6). Because of the difference in urine treatment required for studies of catecholamines and glucocorticoids, it has been necessary to prepare two kinds of urine samples in parallel, i.e., acidified and unpreserved. Clearly it would be preferable if a single urine treatment could be used for analysis of both stress-related hormones. However, to our knowledge, little is known about the stability of these compounds in urine kept under different conditions. In the present study, we examined changes in catecholamine and cortisol concentrations in human urine samples stored at various pH values for different periods, using HPLC and fluorometry. The stability of urinary creatinine was also investigated, because creatinine excretion is commonly used to estimate the exact timing of urine collection. In the present experiments, urinary free catecholamines were assayed using a modification of a method described previously (7). Briefly, 0.5 or 1 mL of urine was adjusted to pH 8.4–8.6 with 1 mol/L NaOH after addition of 100 pmol of isoproterenol as an internal standard and 1 mL of 0.1 mol/L Na2EDTA (pH 8.6); the urine was then adsorbed to 150 mg of alumina packed in a glass column (6 mm i.d.). The alumina was washed twice with 5 mL of water and eluted with 1 mL of 0.25 mol/L acetic acid. The eluate …
A Secure Environment for Untrusted Helper Applications

Many popular programs, such as Netscape, use untrusted helper applications to process data from the network. Unfortunately, the unauthenticated network data they interpret could well have been created by an adversary, and the helper applications are usually too complex to be bug-free. This raises significant security concerns. Therefore, it is desirable to create a secure environment to contain untrusted helper applications. We propose to reduce the risk of a security breach by restricting the program's access to the operating system. In particular, we intercept and filter dangerous system calls via the Solaris process tracing facility. This enabled us to build a simple, clean, user-mode implementation of a secure environment for untrusted helper applications. Our implementation has negligible performance impact, and can protect pre-existing applications.
Microarray analysis of salt-responsive genes in common wheat

We developed oligo-DNA microarrays of common wheat. These microarrays were designed to include approximately 32,000 unique genes represented by a large number of expressed sequence tags (ESTs). In order to characterize the salt-responsive genes in common wheat, the expression profiles of transcripts that responded to salt-treatment were monitored using the microarrays. Two-week-old seedlings of Chinese Spring wheat were treated with 150 mM NaCl for 1 h, 6 h and 24 h, and total RNAs in their roots and shoots were separately subjected to microarray hybridizations. It was observed that 5,996 genes demonstrated a more than 2-fold change in expression. These genes were classified into 12 groups based on their expression patterns. These salt-responsive genes were assigned functions with Gene Ontology (GO) terms. Genes assigned transcription factor, transcription-regulator activity and DNA binding functions were preferentially classified as early-response genes. On the other hand, the genes assigned transferase and transporter activity were classified as late-response genes. These data suggest the existence of multiple signal transduction pathways in response to salt stress in wheat. The expression level of transcription factors (TFs), which have been reported to be involved in the salt-tolerance pathway, were observed to change in response to salt treatment. Only a few of those TFs demonstrated high sequence similarity with genes in rice. Furthermore, comparison of the microarray data for wheat and rice revealed a small number of commonly upor downregulated genes in these plants. These investigations suggest that salt-responsive genes distinct from those observed in rice might exist in wheat. The wheat genes identified in this study are candidates for genes involved in salt-stress tolerance.
Economic cost of cataract surgery procedures in an established eye care centre in Southern India

purpose To estimate the direct and indirect costs of three cataract surgery procedures: extracapsular cataract extraction with intra-ocular lens implantation (ECCE-IOL), phacoemulsification (PHACO) and manual small incision cataract surgery (MSICS) using economic costing principles in a well-established eye care programme (Aravind Eye Hospital) in Tamil Nadu, South India during 2000-01. Previous literature suggests that PHACO and MSICS have similar effectiveness. methods The average unit cost for each surgical procedure was calculated from the societal perspective using economic costing methods. Total annual provider's direct costs for each input to surgery were calculated and apportioned appropriately to different cataract surgery techniques using a 'micro-costing approach'. The patient's direct and indirect costs for each procedure were calculated by interviewing staff and patients and by using assumptions about prices for relevant cost items such as transportation, food, medicine, spectacles and economic productivity loss. results Average provider's direct costs were highest for PHACO procedures (US $25.55) compared to MSICS ($17.03) and ECCE-IOL ($16.25). The difference can be attributed to the cost of equipment and materials. Average direct and indirect patient costs were highest for ECCE-IOL ($19.85), while the costs for PHACO and MSICS were identical ($12.37). ECCE-IOL had the highest total costs and MSICS had the lowest total costs from the societal perspective. conclusions Our results suggest that MSICS may have a lower societal cost than other options. Government and NGO hospitals providing cataract surgeries should invest in regular cost analyses, reviews of the literature on effectiveness, and formal cost-effectiveness analyses in order to plan economically efficient interventions. Considering the small incremental cost for providers (less than US$1), improved outcomes, and lower patient costs, we also believe that MSICS is an important technique to use in efforts to eliminate cataract blindness in India and this result may be generalised to other developing countries.
The Effect of Short‐Term Swiss Ball Training on Core Stability and Running Economy

&NA; Stanton, R. , P. Reaburn, and B. Humphries. The effect of short‐term Swiss ball training on core stability and running economy. J. Strength Cond. Res. 18(3):522–528. 2004. —The purpose of this study was to investigate the effect of a shortterm Swiss ball training on core stability and running economy. Eighteen young male athletes (15.5 ± 1.4 years; 62.5 ± 4.7 kg; &Egr;9 skinfolds 78.9 ± 28.2 mm; SymbolO2max 55.3 ± 5.7 ml·kg‐1·min‐1) were divided into a control (n = 10) and experimental (n = 8) groups. Athletes were assessed before and after the training program for stature, body mass, core stability, electromyographic activity of the abdominal and back muscles, treadmill SymbolO2max, running economy, and running posture. The experimental group performed 2 Swiss ball training sessions per week for 6 weeks. Data analysis revealed a significant effect of Swiss ball training on core stability in the experimental group (p < 0.05). No significant differences were observed for myoelectric activity of the abdominal and back muscles, treadmill SymbolO2max, running economy, or running posture in either group. It appears Swiss ball training may positively affect core stability without concomitant improvements in physical performance in young athletes. Specificity of exercise selection should be considered. Symbol. No caption available.