Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct numerical method for solving a class of fourth-order partial differential equation

In this paper, we classified a class of fourth-order partial differential equations (PDEs) to be fourth-order PDE of type I, II, III and IV. The PDE of type IV is solved by using an efficient numerical method. The PDE is first transformed to a system of fourth-order ordinary differential equations (ODEs) using the method of lines, then the resulting system of fourth-order ODEs is solved using direct Runge-Kutta method (RKFD). The RKFD method is constructed purposely for solving special fourth-order ODEs. Numerical results demonstrated that the RKFD method is in good agreement with the exact solutions.
FCICU at SemEval-2017 Task 1: Sense-Based Language Independent Semantic Textual Similarity Approach

This paper describes FCICU team systems that participated in SemEval-2017 Semantic Textual Similarity task (Task1) for monolingual and cross-lingual sentence pairs. A sense-based language independent textual similarity approach is presented, in which a proposed alignment similarity method coupled with new usage of a semantic network (BabelNet) is used. Additionally, a previously proposed integration between sense-based and sur-face-based semantic textual similarity approach is applied together with our proposed approach. For all the tracks in Task1, Run1 is a string kernel with alignments metric and Run2 is a sense-based alignment similarity method. The first run is ranked 10th, and the second is ranked 12th in the primary track, with correlation 0.619 and 0.617 respectively
Enriching the Doctor-Patient Relationship by Inviting the Patient's Perspective

Doctors and patients alike are saddened and angered by the distance that increasingly interferes with their interactions. Two complementary strategies may enhance the human quality of clinical care and improve outcomes. First, the doctor and patient can undertake a systematic "patient's review" that addresses seven dimensions of care: 1) respect for patient's values, preferences, and expressed needs; 2) communication and education; 3) coordination and integration of care; 4) physical comfort; 5) emotional support and alleviation of fears and anxieties; 6) involvement of family and friends; and 7) continuity and transition. Incorporating the "review" into the clinical encounter encourages both patient and doctor to confront individual preferences and values and offers patients an explicit framework for participating actively in their care. Second, using survey instruments designed to solicit focused reports from patients that address each dimension of care, doctors can gather aggregate feedback about their practices. Such reports move beyond anecdote and can serve as screening tests that uncover areas in doctors' practices that merit improvement. In addition, patients can join doctors in developing solutions to problems uncovered by patients' reports.
O paradigma da cidade compacta no debate urbanístico contemporâneo

Parte das teorias contemporâneas sobre a forma da cidade foca num debate dual: de um lado, estudos analíticos e históricos demonstram a intensidade do crescimento e expansão territorial da urbanização, sua permanência e irreversibilidade, formando o paradigma da cidade dispersa; do outro, estudos que objetivam frear essa dispersão e prover respostas urbanísticas baseadas no resgate de padrões espaciais da cidade "tradicional", formam o paradigma da cidade compacta. Diferentemente da cidade dispersa, o discurso sobre a cidade compacta ainda carece de estudos que o analisem sob uma perspectiva histórica, identificando a rede de conhecimento e influências que o construiu e difundiu na Europa e nas Américas. Este artigo inicia a cobrir esta lacuna a partir de especulações sobre como compacidade e dispersão se apresentam na história recente da cidade e como se construiu o discurso contemporâneo da cidade compacta que, apesar das fortes críticas, não diminuiu seu poder de atração e convencimento. Part of the contemporary theories of urban morphology focus on a dual debate: on one side, analytical and historic studies demonstrate the intensity, permanence and irreversibility of the territorial expansion of the urbanization process, forming the disperse city paradigm; on the other side, studies that aim to refrain this dispersion, providing morphological answers based on rescuing spatial patterns of the “traditional” city, form the compact city paradigm. Unlike the disperse city, the compact city discourse has not been analyzed from a historical perspective, identifying the network of knowledge and theoretical influences that constructed it. This paper starts to cover this gap, speculating on how compactness and dispersion present themselves in the recent city history, and how the contemporary compact city discourse has been constructed, a discourse which, despite the strong critics, has not diminished its attraction and convincing power.
Autism comes to the hospital: The experiences of patients with autism spectrum disorder, their parents and health-care providers at two Canadian paediatric hospitals

Youth with autism spectrum disorder are a vulnerable, often poorly understood patient group, who may experience periodic and chronic health challenges, in addition to their primary developmental social and communication problems. Developmental and behavioural challenges can complicate management of acute health-care needs. To date, there is an absence of empirical research exploring the hospital experiences of children and youth with autism spectrum disorder, their families and their health-care providers. Therefore, the purpose of this study was to understand these experiences in order to inform hospital-based care. A total of 42 participants were interviewed (youth with autism spectrum disorder, their parents and health-care providers) at one of two Canadian paediatric hospitals, representing 20 distinct cases of patients with autism spectrum disorder. Results from the qualitative analyses indicated that patients with autism spectrum disorder faced several challenges in the context of health-care delivery in the hospital setting, as did their families and health-care provider team. Problems identified included communication and sensory challenges, and the degree of flexibility of health-care providers and the hospital organization. Supportive health-care providers were those who acknowledged parents as experts, inquired about the requirements of patients with autism spectrum disorder and implemented strategies that accommodated the unique clinical presentation of the individual patient. These recommendations have wide-reaching utility for hospital and health-care practices involving this patient group.
Ascidians as excellent chordate models for studying the development of the nervous system during embryogenesis and metamorphosis

The swimming larvae of the chordate ascidians possess a dorsal hollowed central nervous system (CNS), which is homologous to that of vertebrates. Despite the homology, the ascidian CNS consists of a countable number of cells. The simple nervous system of ascidians provides an excellent experimental system to study the developmental mechanisms of the chordate nervous system. The neural fate of the cells consisting of the ascidian CNS is determined in both autonomous and non‐autonomous fashion during the cleavage stage. The ascidian neural plate performs the morphogenetic movement of neural tube closure that resembles that in vertebrate neural tube formation. Following neurulation, the CNS is separated into five distinct regions, whose homology with the regions of vertebrate CNS has been discussed. Following their larval stage, ascidians undergo a metamorphosis and become sessile adults. The metamorphosis is completed quickly, and therefore the metamorphosis of ascidians is a good experimental system to observe the reorganization of the CNS during metamorphosis. A recent study has shown that the major parts of the larval CNS remain after the metamorphosis to form the adult CNS. In contrast to such a conserved manner of CNS reorganization, most larval neurons disappear during metamorphosis. The larval glial cells in the CNS are the major source for the formation of the adult CNS, and some of the glial cells produce adult neurons.
Effect of lanthanum ions on function and structure of frog neuromuscular junctions

1. Electrophysiological and electron-microscopic studies were made of the effect of lanthanum ions on frog neuromuscular junctions. 2. In the presence of 1 mM La2+, nerve impulses continued to invade the nerve terminals but ceased to release transmitter. 3. Lanthanum caused a rapid and large increase in the frequency of miniature end-plate potentials; presumably because La activates the mechanism of transmitter release without the usual prerequisite of presynaptic membrane depolarization. At 4 °C, La caused a 10000-fold, or even larger increase in the rate of leakage of transmitter quanta. Such high rate of transmitter release was not accompanied by obvious changes in electron-microscopic structure of the nerve terminals. 4. With continued La-treatment, the frequency of miniature end-plate potentials subsides slowly until they are no longer detectable at most end-plates. During this period the number of synaptic vesicles is reduced until practically all the endings become completely depleted of synaptic vesicles. In contrast, coated vesicles and membrane-bound tubes and cysternae become more numerous.
Fecal and oral shedding of Helicobacter pylori from healthy infected adults.

CONTEXT Helicobacter pylori commonly infects humans; however, its mode of transmission remains unknown. OBJECTIVE To determine how humans-the primary host for H pylori-shed the organism into the environment. DESIGN Controlled clinical experimental study conducted from February through December 1998. SETTING Clinical research unit of a hospital in northern California. PATIENTS Sixteen asymptomatic H pylori-infected and 10 uninfected adults. INTERVENTION A cathartic (sodium phosphate) and an emetic (ipecac) were given to all infected subjects and an emetic was given to 1 uninfected subject. MAIN OUTCOME MEASURE Confirmed H pylori isolates cultured from stool, air, or saliva before and after catharsis and emesis and from vomitus during emesis. Isolates were fingerprinted using repetitive extragenic palindromic (REP) polymerase chain reaction and species identity was confirmed by sequencing the 16s ribosomal RNA gene. RESULTS All vomitus samples from infected subjects grew H pylori, often in high quantities. Air sampled during vomiting grew H pylori from 6 (37.5%) of the 16 subjects. Saliva before and after emesis grew low quantities of H pylori in 3 (18.8%) and 9 (56.3%) subjects, respectively. No normal stools and only 22 (21.8%) of 101 induced stools grew the organism, although 7 (50.0%) of 14 subjects had at least 1 positive culture (2 stool culture samples were contaminated by fungus and were not included). Fingerprints of isolates within subjects were identical to one another but differed among subjects. No samples from uninfected subjects yielded H pylori. CONCLUSIONS Helicobacter pylori can be cultivated uniformly from vomitus and, occasionally, from saliva and cathartic stools. The organism is potentially transmissible during episodes of gastrointestinal tract illness, particularly with vomiting.
Septicemic Listeriosis in Wild Hares from Saskatchewan, Canada

Abstract The bacterium Listeria monocytogenes causes disease in a wide variety of mammals including rabbits and hares. We describe naturally acquired metritis and septicemic listeriosis in wild female hares from Saskatchewan, Canada. Between April 2012 and July 2013, two white-tailed jackrabbits (Lepus townsendii) and a snowshoe hare (Lepus americanus) were presented to the Veterinary Medical Centre at the Western College of Veterinary Medicine, Saskatoon, Saskatchewan, Canada with nonspecific neurologic signs. The hares were euthanized and autopsied. Necrotizing fibrinosuppurative metritis was present in all. Additional findings in individual hares included fetal maceration, multifocal necrotizing myocarditis, multifocal hepatic necrosis, and nonsuppurative encephalitis. Listeria monocytogenes was cultured from multiple tissues in each hare. Although listeriosis in pregnant domestic rabbits has been studied, this is the first detailed description in wild North American hares. The epidemiology of listeriosis, including prevalence and the role of environmental sources and coprophagy in transmission among hares, requires further investigation.
Convertidor multinivel trifásico con enclavamiento por diodos con modulación PWM optimizada

Resumen– En este trabajo se presenta un analisis de las caracteristicas de conmutacion de la topologia multinivel con enclavamiento por diodos, con el fin de asegurar el correcto funcionamiento del convertidor. Tambien se incluye el modelado del inversor para 11 niveles y la realizacion de simulaciones a traves de MATLAB para comprobar su desempeno en el proceso de conversion de la energia; ademas se llevan a cabo simulaciones del inversor en vacio, con cargas resistiva, resistiva-inductiva, resistiva-capacitiva, efectuando un analisis de la calidad de la energia suministrada con el fin de medir la eficiencia del inversor como mitigador de la distorsion armonica. Por ultimo se muestra y se analiza el comportamiento de los condensadores del bus de continua para los diferentes tipos de carga. Palabras claves-Inversor Multinivel, fijacion de diodos, modelado, simulacion, distorsion armonica.
VEGF and Angiopoietins Promote Inflammatory Cell Recruitment and Mature Blood Vessel Formation in Murine Sponge/Matrigel Model

A key feature in the induction of pathological angiogenesis is that inflammation precedes and accompanies the formation of neovessels as evidenced by increased vascular permeability and the recruitment of inflammatory cells. Previously, we and other groups have shown that selected growth factors, namely vascular endothelial growth factor (VEGF) and angiopoietins (Ang1 and Ang2) do not only promote angiogenesis, but can also induce inflammatory response. Herein, given a pro‐inflammatory environment, we addressed the individual capacity of VEGF and angiopoietins to promote the formation of mature neovessels and to identify the different types of inflammatory cells accompanying the angiogenic process over time. Sterilized polyvinyl alcohol (PVA) sponges soaked in growth factor‐depleted Matrigel mixed with PBS, VEGF, Ang1, or Ang2 (200 ng/200 µl) were subcutaneously inserted into anesthetized mice. Sponges were removed at day 4, 7, 14, or 21 post‐procedure for histological, immunohistological (IHC), and flow cytometry analyses. As compared to PBS‐treated sponges, the three growth factors promoted the recruitment of inflammatory cells, mainly neutrophils and macrophages, and to a lesser extent, T‐ and B‐cells. In addition, they were more potent and more rapid in the recruitment of endothelial cells (ECs) and in the formation and maturation (ensheating of smooth muscle cells around ECs) of neovessels. Thus, the autocrine/paracrine interaction among the different inflammatory cells in combination with VEGF, Ang1, or Ang2 provides a suitable microenvironment for the formation and maturation of blood vessels. J. Cell. Biochem. 116: 45–57, 2015. © 2014 Wiley Periodicals, Inc.
On null complementizers in Spanish

In the present paper I propose that a given class of predicates, that I call, with Cattell (1978), Stance Predicates, selects an additional feature of assertion in their finite dependents, and that this additional feature is realized as a null complementizer, standardly assumed in sentences such as (lb) below (Torrego 1983). This null complementizer is involved in checking features of point of view, in the sense of Uriagereka (1995a, b), and plays a crucial role in the deictic evaluation of the embedded proposition. The purpose of the paper, besides examining in detail the syntax of null complementizers in indicative dependents, is that of providing a first step in the syntactic formalization of a subclass of deictic relations: those holding of the ascription of propositional attitudes.
Virtue Out of Necessity?: Compliance, Commitment and the Improvement of Labor Conditions in Global Supply Chains

Private, voluntary compliance programs, promoted by global corporations and non-governmental organizations alike, have produced only modest and uneven improvements in working conditions and labor rights in most global supply chains. Through a detailed study of a major global apparel company and its suppliers, this paper argues that this compliance model rests upon misguided theoretical and empirical assumptions concerning the power of multinational corporations in global supply chains; the role information (derived from factory audits) plays in shaping the behavior of key actors (i.e., global brands, transnational activist networks, suppliers, purchasing agents, etc.) in these production networks; and the appropriate incentives required to change behavior and promote improvements in labor standards in these emergent centers of global production. We argue that it is precisely these faulty assumptions and the way they have come to shape various labor compliance initiatives throughout the world - even more than a lack of commitment, resources, or transparency by global brands and their suppliers to these programs - that explains why this compliance-focused model of private voluntary regulation has not succeeded. In contrast, this paper documents that a more commitment-oriented approach to improving labor standards co-exists, and in many of the same factories, complements the traditional compliance model. This commitment-oriented approach, based upon joint problem solving, information exchange, and the diffusion of best-practices, is often obscured by the debates over traditional compliance programs but it exists in myriad factories throughout the world and has led to sustained improvements in working conditions and labor rights at these workplaces.
Human antibody response to a group B serotype 2a meningococcal vaccine determined by immunoblotting

The antibody response of 30 volunteers vaccinated with a complex of group B polysaccharide and outer membrane vesicles (OMV) from serotype 2a Neisseria meningitidis and of 3 individuals who received a placebo vaccine was determined by immunoblotting. OMV were separated by sodium dodecyl sulfate-gel electrophoresis and electrotransferred to nitrocellulose filters. Binding of immunoglobulin G (IgG), IgA, and IgM antibodies in the human sera to OMV components was detected with class-specific peroxidase-conjugated antibodies. The immunoblotting results were also related to the bactericidal activity of the sera and the meningococcal carrier status of the volunteers. Before vaccination weakly reactive bands in the molecular weight range of 140,000 to 10,000 were observed on the blots. Sera from carriers showed more marked bands. Individual patterns of increased reactivity were seen 6 weeks after vaccination. The main immunoreactive components of OMV corresponded to a molecular weight of 43,000 (class 1 protein), 30,000 (class 5 proteins), and 22,000. IgG antibodies in postvaccination sera of high bactericidal titers showed distinct binding to the 43,000-molecular-weight antigen. Meningococcal carriers had antibodies against an antigen of 22,000 molecular weight; in polyacrylamide gels this component did not stain with Coomassie brilliant blue or silver. The marked binding of IgG antibodies to the class 5 proteins decreased considerably between weeks 6 and 25 after vaccination. Periodate oxidation of OMV abolished the binding of IgG antibodies to the class 5 proteins, whereas the antigenicity of the 43,000-molecular-weight (class 1 protein) and 22,000-molecular-weight antigens was unaffected.
Non-Reductionism and Special Concern

The so-called ‘Extreme Claim’ asserts that reductionism about personal identity leaves each of us with no reason to be specially concerned about his or her own future. Both advocates and opponents of the Extreme Claim, whether of a reductionist or non-reductionist stripe, accept that similar problems do not arise for non-reductionism. In this paper I challenge this widely held assumption.
Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets.

1. Acetyl-CoA carboxylase was purified to homogeneity, in the presence of protein phosphatase inhibitors, from rat liver sampled without freeze-clamping. The enzyme was in a highly phosphorylated state (4.8 mol/subunit) of low specific activity, and could be dramatically reactivated by treatment with protein phosphatase-2A. Amino acid sequencing and fast-atom-bombardment mass spectrometry showed that the enzyme was phosphorylated in Ser79, Ser1200 and Ser1215, the three sites known to be phosphorylated in cell-free assays by the AMP-activated protein kinase. 2. The inactive enzyme could also be completely reactivated using a limited treatment with trypsin, which removes the N-terminal segment containing Ser79 and reduces the phosphate content to 3.5 mol/subunit. These results strengthen previous findings that it is phosphorylation at Ser79 by the AMP-activated protein kinase that is responsible for the inactivation, and not the phosphorylation of the 220-kDa core fragment (which contains Ser1200 and Ser1215). 3. Analysis of the phosphorylation state of Ser79 in acetyl-CoA carboxylase from rat liver showed that phosphorylation occurs post mortem if freeze-clamping is not used. The higher phosphorylation observed in extracts made without freeze-clamping correlates with a large increase in AMP and decrease in ATP (presumably caused by hypoxia during removal of the liver), and with increased activity of the AMP-activated protein kinase. These results provide a rational explanation for the post mortem phosphorylation events, and re-emphasize the point that rapid cooling of cells and tissues is essential when measuring the expressed activity of acetyl-CoA carboxylase (as well as 3-hydroxy-3-methylglutaryl-CoA reductase). 4. Using the freeze-clamping procedure, the ratio of 'expressed' activity (measured in the presence of protein phosphatase inhibitors) to 'total' activity (measured after complete dephosphorylation) of rat liver acetyl-CoA carboxylase showed a marked diurnal rhythm, changing from 50% in the active form in the middle of the dark period to less than 10% active in the middle of the light period. The very low activity in the light period was associated with a high level of phosphorylation in Ser79. This diurnal rhythm is very similar to that previously described for the phosphorylation of 3-hydroxy-3-methylglutaryl-CoA reductase, another substrate for the AMP-activated protein kinase. Neither the activity of the AMP-activated protein kinase nor the content of AMP, ADP or ATP changed between the dark or light periods. (ABSTRACT TRUNCATED AT 400 WORDS)