Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.

OBJECTIVE There is a need for clearly defined and widely applicable clinical criteria for the selection of patients who may benefit from hepatic resection for metastatic colorectal cancer. Such criteria would also be useful for stratification of patients in clinical trials for this disease. METHODS Clinical, pathologic, and outcome data for 1001 consecutive patients undergoing liver resection for metastatic colorectal cancer between July 1985 and October 1998 were examined. These resections included 237 trisegmentectomies, 394 lobectomies, and 370 resections encompassing less than a lobe. The surgical mortality rate was 2.8%. RESULTS The 5-year survival rate was 37%, and the 10-year survival rate was 22%. Seven factors were found to be significant and independent predictors of poor long-term outcome by multivariate analysis: positive margin (p = 0.004), extrahepatic disease (p = 0.003), node-positive primary (p = 0.02), disease-free interval from primary to metastases <12 months (p = 0.03), number of hepatic tumors >1 (p = 0.0004), largest hepatic tumor >5 cm (p = 0.01), and carcinoembryonic antigen level >200 ng/ml (p = 0.01). When the last five of these criteria were used in a preoperative scoring system, assigning one point for each criterion, the total score was highly predictive of outcome (p < 0.0001). No patient with a score of 5 was a long-term survivor. CONCLUSION Resection of hepatic colorectal metastases may produce long-term survival and cure. Long-term outcome can be predicted from five criteria that are readily available for all patients considered for resection. Patients with up to two criteria can have a favorable outcome. Patients with three, four, or five criteria should be considered for experimental adjuvant trials. Studies of preoperative staging techniques or of adjuvant therapies should consider using such a score for stratification of patients.
Transgenic Targeting of a Dominant Negative Corepressor to Liver Blocks Basal Repression by Thyroid Hormone Receptor and Increases Cell Proliferation*

Unliganded thyroid hormone receptors (TRs) interact with corepressors and repress basal transcription of target genes in cotransfection and in vitro studies. Currently, little is known about the function of corepressorsin vivo. We thus used a mouse albumin promoter to generate several transgenic mouse lines that overexpressed a dominant negative mutant corepressor, NCoRi, in liver. The transgenic mice had normal liver weight, appearance, and minimal changes in enzyme activity. To study the effects of NCoRi on transcription of hepatic target genes, we examined T3-regulated gene expression of hypo- and hyperthyroid transgenic mice. In hypothyroid mice, hepatic expression of Spot 14, Bcl-3, glucose 6-phosphatase, and 5′-deiodinase mRNA was higher in transgenic mice than littermate controls whereas these genes were induced to similar levels in T3-treated mice. Derepression was not observed for malic enzyme mRNA expression in hypothyroid mice. Thus, NCoRi selectively blocked basal transcription of several thyroid hormone-responsive genes but had no effect on ligand-mediated transcription. Additionally, compensatory increases in endogenous SMRT and NCoR mRNA were observed in hypothyroid transgenic mice. Interestingly, hepatocyte proliferation as detected by BrdUrd incorporation was increased in transgenic mice. The gene profile in transgenic mouse livers was studied by cDNA microarray, and several genes related to cell proliferation were induced. In summary, our studies show that NCoR plays important roles in mediating basal repression by TRs and may prevent cellular proliferation in vivo.
Adapting the TANL tool suite to Universal Dependencies

TANL is a suite of tools for text analytics based on the software architecture paradigm of data driven pipelines. The strategies for upgrading TANL to the use of Universal Dependencies range from a minimalistic approach consisting of introducing pre/post-processing steps into the native pipeline to revising the whole pipeline. We explore the issue in the context of the Italian Treebank, considering both the efforts involved, how to avoid losing linguistically relevant information and the loss of accuracy in the process. In particular we compare different strategies for parsing and discuss the implications of simplifying the pipeline when detailed part-of-speech and morphological annotations are not available, as it is the case for less resourceful languages. The experiments are relative to the Italian linguistic pipeline, but the use of different parsers in our evaluations and the avoidance of language specific tagging make the results general enough to be useful in helping the transition to UD for other languages.
Human puromycin-sensitive aminopeptidase: cloning of 3′ UTR, evidence for a polymorphism at aa 140 and refined chromosomal localization to 17q21

Puromycin-sensitive aminopeptidase is a predominantly cytoplasmatic zinc-dependent exopeptidase. Its physiological function is not known to date. Here we report data on tissue distribution, a polymorphism within the coding region and the complete 3′ UTR. The gene (NPEPPS alias PSA) was physically mapped to chromosome 17q21.2→q21.32 using fluorescence in situ hybridization.
Association of obstructive sleep apnea risk with asthma control in adults.

BACKGROUND Unrecognized obstructive sleep apnea (OSA) may lead to poor asthma control despite optimal therapy. Our objective was to evaluate the relationship between OSA risk and asthma control in adults. METHODS Patients with asthma seen routinely at tertiary-care clinic visits completed the validated Sleep Apnea Scale of the Sleep Disorders Questionnaire (SA-SDQ) and Asthma Control Questionnaire (ACQ). An ACQ score of >or= 1.5 defined not-well-controlled asthma, and an SA-SDQ score of >or= 36 for men and >or= 32 for women defined high OSA risk. Logistic regression was used to model associations of high OSA risk with not-well-controlled asthma (ACQ full version and short versions). RESULTS Among 472 subjects with asthma, the mean +/- SD ACQ (full version) score was 0.87 +/- 0.90, and 80 (17%) subjects were not well controlled. Mean SA-SDQ score was 27 +/- 7, and 109 (23%) subjects met the definition of high OSA risk. High OSA risk was associated, on average, with 2.87-times higher odds for not-well-controlled asthma (ACQ full version) (95% CI, 1.54-5.32; P = .0009) after adjusting for obesity and other factors known to worsen asthma control. Similar independent associations were seen when using the short ACQ versions. CONCLUSIONS High OSA risk is significantly associated with not-well-controlled asthma independent of known asthma aggravators and regardless of the ACQ version used. Patients who have difficulty achieving adequate asthma control should be screened for OSA.
Progressive Esophagitis Caused by Candida albicans with Reduced Susceptibility to Caspofungin

Candida esophagitis, a defining illness of acquired immunodeficiency syndrome (AIDS), requires systemic antifungal therapy. Candida albicans can become resistant to commonly administered azole antifungal agents. An attractive alternative is caspofungin, an echinocandin antifungal that has generally displayed predictable activity against C. albicans. We report the case of a 29‐year‐old woman with AIDS who developed recurrent esophagitis caused by a strain of C. albicans that showed reduced susceptibility to caspofungin (elevated minimum inhibitory concentration of 8 mg/L). Analysis of the strain revealed that it contained a serine‐to‐proline substitution at position 645 in the FKS1 gene. Clinicians who prescribe caspofungin to treat esophagitis caused by C. albicans should recognize the potential risk, albeit slight, for acquired resistance to caspofungin and possibly other echinocandin antifungal agents in the face of persistent disease. In patients who are refractory or unresponsive to caspofungin therapy, susceptibility testing and/or alternative therapy should be considered.
Gender differences in the developmental risk of onset of alcohol, nicotine, and marijuana use and the effects of nicotine and marijuana use on alcohol outcomes.

OBJECTIVE This study aimed to (a) characterize gender-specific risk of onset of alcohol, nicotine, and marijuana use developmentally; (b) investigate the effects of early-onset status and frequency of nicotine and marijuana use on alcohol outcomes, controlling for the effects of alcohol use; and (c) examine gender differences in the developmental trajectories of alcohol outcomes and the effects of nicotine and marijuana use on alcohol outcomes. METHOD This study conducted secondary analysis on a longitudinal study that recruited at-risk youth through fathers' drunk-driving records and door-to-door canvassing in the midwestern United States. The sample included 160 female-male sibling pairs who were assessed on substance use and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis from early childhood to young adulthood. RESULTS Although males were at higher risk for being early-onset alcohol users, females tended to be at higher risk for initiating marijuana use at younger ages. When early onset and amount of alcohol use were controlled for, early onset of nicotine and marijuana use did not contribute to alcohol outcomes, but frequencies of nicotine and marijuana use did. We also found the associations of quantity/frequency of alcohol and marijuana use with drinking problems to be stronger among females than among males. CONCLUSIONS Higher frequencies of nicotine and marijuana use may contribute to worse alcohol outcomes above and beyond the effect of alcohol use. Females tend to be at higher risk than males for initiating marijuana use and meeting an alcohol use disorder diagnosis at younger ages as well as being more vulnerable to a negative impact of alcohol and marijuana use.
Optimal battery energy storage system control in microgrid with renewable energy generation

With the wide use of the renewable sources in the generation of power grid, the high variability of the renewable source output leads to voltage instability and potential cost, which imposes significant challenges to the power grid. Battery energy storage has been considered as an effective mechanism to minimize the fluctuation of power flow exchanged with the main grid in a system with renewable energy sources. In this paper, we consider the optimal control of battery energy storage system (BESS) in a microgrid with renewable energy sources. In particular, we aim to minimize a cost function, which is a general convex increasing function of instantaneous power flow from the grid. The increasing convexity of the cost function makes sure that the power flow from the main grid is as flat over time as possible, and thus minimizes the negative impact of renewable energy integration. Through rigorous analysis, we show that the optimal BESS operation policy exhibits a threshold structure, which can potential lead to a simplified control policy. The threshold structure is validated through extensive simulations. Our results demonstrate that the BESS can significantly reduce the fluctuation of power flow exchanged with the main grid. Besides, we also discuss the effect of BESS capacity on the total cost.
Error Equidistribution and Mesh Adaptation

The author reviews a number of strategies on mesh adaptation from a mathematical point of view and compares their performances in solving nonlinear diffusion models from semiconductor process modeling. Some new strategies are then proposed that improve on the existing ones. The analysis of the strategies based on monitoring interpolation errors and local truncation errors leads to a new theory on error equidistribution. Several implementation methods for equidistributing an error monitor function are also reviewed and outstanding problems are highlighted.
Environment and Land Use in the Wadi Faynan, Southern Jordan: the Second Season of Geoarchaeology and Landscape Archaeology (1997)

AbstractThis report describes the third season of fieldwork by an interdisciplinary team of archaeologists and geographers working to reconstrnct the landscape history of the Wadi Faynan in southern Jordan over the past 200,000 years. The particular focus of the project is the long-term history of inter-relationships between landscape and people, as a contribution to the study of processes of desertification and environmental degradation. The geomorphological and palaeoecological studies have now established the outline sequence of landform changes and climatic fluctuations in the late Pleistocene and Holocene. The complex field system WF4 has now been recorded in its entirety in terms of wall construction, suiface artefacts, and hydrological features, as well as most of the outlying field systems. From these studies, in combination with the analysis of the suiface artefacts, an outline sequence of the water utilization and management strategies they represent can now be discerned. Ethnoarchaeology is als.
Breed effects and heterosis in advanced generations of composite populations for puberty and scrotal traits of beef cattle.

Heterosis effects were evaluated in F1, F2, and F3 generations of females and in the F1, F2, and combined F3 and F4 generations of males in three composite populations of beef cattle. Traits included weight, height, and condition scores at different ages, percentage of females reaching puberty at 368, 410, and 452 d, adjusted age, and adjusted weight of females at puberty and scrotal circumference and paired testicular volume of males. Breed effects were evaluated for the nine parental breeds (Red Poll [R], Hereford [H], Angus [A], Limousin [L], Braunvieh [B], Pinzgauer [P], Gelbvieh [G], Simmental [S], and Charolais [C]) that contributed to the three composite populations (MARC I = 1/4 C, 1/4 B, 1/4 L, 1/8 H, 1/8 A; MARC II = 1/4 G, 1/4 S, 1/4 H, 1/4 A; and MARC III = 1/4 R, 1/4 P, 1/4 H, 1/4 A). Breed effects were significant for all traits evaluated. Heterosis was significant for weight, height, and condition score at all ages and for most measures of puberty in each generation of each composite and for the mean of the three composite populations. Heterosis for age at puberty was largely independent of heterosis effects on 368-d weight. Heterosis was significant for scrotal circumference and paired testicular volume in each generation of each composite and for the mean of the three composite populations. Heterosis effects on scrotal measurements are mediated both through heterosis effects on growth rate and through factors that are independent of growth rate. Correlation coefficients among breed group means and correlations of breed rank for scrotal measurements with puberty traits of females were greater than or equal to . 88 (P less than .01) for all puberty traits except weight at puberty, which was not associated with scrotal measurements. There was close agreement in heterosis observed for most traits and expectation based on retained heterozygosity. These results support the hypothesis that heterosis in cattle for size, puberty, and scrotal measurement traits is due to dominance effects of genes.
An ex ante evaluation of the eects of banning advertising on junk food markets

We develop a structural model to analyze the eects of banning advertising on demand, supply and market equilibria in junk food markets. We use transaction level data on the potato chips market and nd that banning advertising does not lead to a reduction in demand because, while banning advertising reduces consumers’ taste for junk food, it also toughens price competition, leading to lower prices. Overall consumers do not lower calories from potato chips, but they are led to buy healthier varieties. We also consider the impact of the ban on consumer welfare, showing how to evaluate consumer welfare when advertising is persuasive and might lead consumers to take decisions that are inconsistent with their underlying preferences.
Asthma, asthmalike symptoms, chronic bronchitis, and the degree of bronchial hyperresponsiveness in epidemiologic surveys.

Measurement of bronchial hyperresponsiveness has been suggested to be a useful test in identifying subjects with asthma in epidemiologic groups. We explored the association between the degree of bronchial hyperresponsiveness, respiratory symptoms suggestive of asthma, chronic bronchitis, and various definitions of asthma based upon information obtained from a questionnaire. We determined bronchial hyperresponsiveness by methacholine inhalation test, administered a standardized respiratory questionnaire, and performed spirometry on 1,392 male workers in various industries: 229 (16.5%) had PC20 less than 8 mg/ml, 66 (4.7%) had PC20 less than 2 mg/ml, and 8 (0.6%) had PC20 less than 0.5 mg/ml. Only 760 workers had no respiratory symptoms; no workers with PC20 less than or equal to 0.5 mg/ml, 31.0% of workers with PC20 greater than 0.5 but less than or equal to 2 mg/ml, and 38.0% of workers with PC20 greater than 2 but less than or equal to 8 mg/ml had no chest symptoms. Those reporting wheeze or breathlessness, and especially those with both symptoms, were significantly more likely to have bronchial hyperresponsiveness with a low PC20. The reporting of chest tightness did not influence this relationship, and there was no difference between the occurrence of "wheeze without a cold" and "persistent wheeze. " Although there was a stronger association of PC20 less than or equal to 2 mg/ml with asthma than with chronic bronchitis, the association of PC20 greater than 2 and less than or equal to 8 mg/ml was not different with asthma than with chronic bronchitis. Bronchial hyperresponsiveness was more closely associated with asthma than with any asthmalike symptoms ascertained by a questionnaire developed for the study of chronic bronchitis. (ABSTRACT TRUNCATED AT 250 WORDS)
An Empirical Assessment of What We Know About Structural Covariates of Homicide Rates: A Return to a Classic 20 Years Later

As the 20-year mark since the publication of an article by Kenneth C. Land, Patricia L. McCall, and Lawrence Cohen, “Structural Covariates of Homicide Rates: Are There Any Invariances Across Time and Social Space? ” approaches, the question that these scholars originally posed is raised again: Have researchers been able to identify a set of robust structural covariates that consistently predict crime rates? Subsequent to the publication of this piece, numerous scholars have replicated and extended its conceptual, methodological, and empirical work in various ways—with more than 500 citations to date. In response to this attention, the authors first review the advances made by the Land et al. article. This is followed by a review of findings from studies published over the past 20 years to determine which structural predictors identified in the Land et al. piece continue to be prominent in the study of homicide and which structural predictors have surfaced in recent years as influential to crime rates. Using data on U.S. cities for the years 1970, 1980, 1990, and 2000, the authors then present a systematic empirical assessment of the explanatory power of the covariates of homicide rates identified in the Land et al. study. Twenty years later, we find support for the claims of invariance established in Land et al. and acknowledge the contributions of this piece to the macrolevel study of homicide rates.
Post-traumatic growth in people living with a serious medical condition and its relations to physical and mental health: A systematic review

Purpose. The diagnosis of a life-threatening illness can be an extremely stressful, traumatic experience. However, many survivors report also various positive changes, referred in empirical literature as post-traumatic growth (PTG). Empirical studies that documented stress disorders and PTG in patients and survivors of life-threatening diseases are reviewed in three areas: Predictors of PTG, relationships between PTG and indicators of mental health and the impact of PTG on the process of convalescence. Method. The literature review was completed by making use of three major databases – PsycINFO, PILOTS and Medline. Results. The majority of the studies investigated PTG and its relationships to health indicators after the diagnosis of cancer, HIV/AIDS, cardiac disease, multiple sclerosis and rheumatoid arthritis. The review indicated that quality of social support, patients' coping strategies and several indicators of mental and physical health were consistently associated with post-traumatic growth. Associations between growth and health-related variables (e.g. physical deficits, pain, depression, anxiety) varied depending on different study design (cross-sectional versus longitudinal) and the sample composition (patients versus symptom-free survivors). Several findings are disease-specific. Conclusions. The results point to the potential adaptive significance of PTG. More research is needed to investigate specific disease-related profiles of PTG and the complex mechanisms, which underlie the relationships between PTG and the process of convalescence. This knowledge may help to foster the overall positive adjustment of chronically ill patients.
Low-molecular-weight heparin dosage in newborn foals.

BACKGROUND Heparin is used in humans as prophylaxis of hypercoagulable states and disseminated intravascular coagulation (DIC). However, babies need a higher heparin dose than do adults. Septic neonate foals are at high risk of hypercoagulable state and DIC, and there is limited objective information about heparin dose for equine neonates. OBJECTIVE To assess whether neonate foals require higher dosages of low-molecular-weight heparin (LMWH) than adults. ANIMALS Eighteen healthy and 11 septic neonate foals. METHODS Experimental and clinical studies. Firstly, healthy foals were randomly distributed in 2 groups, 1 receiving 50 IU/kg SC of dalteparin and the 2nd group receiving 100 IU/kg SC of dalteparin, once daily for 3 days. Blood samples were collected before and 3, 6, 27, and 51 hours after the 1st LMWH administration. Plasma antifactor-Xa activity was measured, together with hemostatic and hematologic parameters used to assess the risk of bleeding. Subsequently, septic foals were treated blindly either with placebo (saline) or 100 IU/kg of dalteparin for 3 days. Plasma antifactor-Xa activity and other hemostatic parameters were determined before and after treatment. RESULTS Plasma antifactor-Xa activity in healthy foals was below prophylactic activity when using the adult dosage (50 IU/kg), whereas prophylactic activities were achieved when using the double dosage (100 IU/kg). No hemorrhagic events and erythrocyte-related complications were observed with either dosage. In the clinical study, only 4/6 septic foals had plasma antifactor-Xa activity adequate for prophylaxis. CONCLUSIONS AND CLINICAL IMPORTANCE Equine neonates require higher dosages of LMWH compared with adults to reach prophylactic heparinemia.
Novel Approaches Towards Leakage Flux Reduction in Axial Flux Switched Reluctance Machines

First, exclusive investigations are performed in this paper on a developed prototype of an axial flux switched reluctance machine to elicit the issues of low inductance ratio due to higher leakage flux in this type of machine. Thereafter, three different novel approaches based on a special winding configuration, segmented grain-oriented steel core and magnetic shielding are proposed to mitigate the leakage flux. These approaches are then tested individually using 3-D FEA. In addition, comparative performance analysis of the original machine model and the machine with each of these approaches is carried out.