Miracle-dz/UniFAR-FTUs huggingface dataset:
Simulation-based comprehensive study of batch effects in metabolomics studies

Batch effects will influence the interpretation of metabolomics data. In order to avoid misleading results, batch effects should be corrected and normalized prior to statistical analysis. Metabolomics studies are usually performed without targeted compounds (e.g., internal standards) and it is a challenging task to validate batch effects correction methods. In addition, statistical properties of metabolomics data are quite different from genomics data (where most of the currently used batch correction methods have originated from). In this study, we firstly analyzed already published metabolomics datasets so as to summarize and discuss their statistical properties. Then, based on available datasets, we developed novel statistical properties-based in silico simulations of metabolomics peaks’ intensity data so as to analyze the influence of batch effects on metabolomic data with the use of currently available batch correction strategies. Overall, 252000 batch corrections on 14000 different in silico simulated datasets and related differential analyses were performed in order to evaluate and validate various batch correction methods. The obtained results indicate that log transformations strongly influence the performance of all investigated batch correction methods. False positive rates increased after application of batch correction methods with almost no improvement on true positive rates among the analyzed batch correction methods. Hence, in metabolomic studies it is recommended to implement preliminary experiments to simulate batch effects from real data in order to select adequate batch correction method, based on a given distribution of peaks intensity. The presented study is reproducible and related R package mzrtsim software can be found online (https://github.com/yufree/mzrtsim).
Interacción genotipo por ambiente para proteína, aceite y rendimiento de soja en la Región Pampeana Norte de Argentina

La concentración de proteína y aceite son los principales determinantes del valor industrial del cultivo de soja. El posicionamiento de Argentina en el contexto mundial como productor y exportador de soja y sus derivados es muy importante. Es tercer productor y exportador de poroto de soja y ocupa el primer puesto como exportador de aceite, harina de soja y biodiesel. En Argentina, los cultivares más difundidos han sido seleccionados por su alto potencial de rendimiento. Generalmente éste se asocia a una disminución en el contenido de proteína debido a la correlación negativa que suele encontrarse entre dichos parámetros (Cober and Voldeng, 2000). El rendimiento en grano y los parámetros de calidad industrial de soja como contenido de proteína y aceite están influenciados por el ambiente de producción (localidad, año, condiciones climáticas, manejo) y la genética (Bosaz et al., 2019 y Cuniberti et al., 2011a; Herrero et al., 2017). En cuanto al contenido de aceite, la soja argentina se caracteriza por presentar en líneas generales altos valores para el parámetro, destacándose la Región Norte (I) con los valores más altos, seguida por la Región Pampeana Norte (II) y luego la Región Pampeana Sur (III) según el mapa de Regiones y Subregiones de cultivo para la recomendación de cultivares de la Red Nacional de Evaluación de Cultivares de Soja (RECSO), debido en parte a que altas temperaturas en llenado de grano favorecen un mayor contenido de aceite (Herrero et al., 2006; Cuniberti et al., 2011b). Considerando el contenido de proteína se observa una marcada caída en los últimos años, siendo una problemática que debe enfrentar la industria local para lograr obtener una harina Hi-Pro que cumpla con el standard mínimo de comercialización internacional del 46,5% (Calzada y Rozadilla, 2018; Cuniberti y Herrero, 2013). El manejo de la producción y la genética por medio de la elección de cultivares son aspectos a considerar para hacer frente a este descenso. El objetivo de este trabajo es conocer el comportamiento de cultivares del Grupo de Madurez IVL en la Región Pampeana Norte para porcentaje de proteína, aceite y rendimiento y hallar aquellos que se destacan combinando un buen comportamiento en rendimiento y calidad Industrial.
Evaluation Model of DC Current Distribution in AC Power Systems Caused by Stray Current of DC Metro Systems

With the rapid development of the DC metro system, the stray current may bring new challenges to the AC power system. Especially, the stray current of the DC metro system flowing in the AC power system may cause many serious consequences such as the corrosion of the grounding grids, plenty of harmonics, and the dc bias of transformers. Therefore, it is significant to evaluate the dc current distribution in the AC power system caused by the stray current. In order to evaluate the dc current distribution, a coupled simulation model both considering the DC metro system and the AC power system is proposed in this paper. Moreover, the earth and the grounding system are both used as the coupling elements in the proposed model. The correctness of the proposed model is verified by the comparison of the calculation results and the field test data. Furthermore, based the proposed model, the dc current distribution in the AC power system is evaluated and analyzed. The results indicate that the dc current distribution is affected by the trains operating conditions and the relative position between the DC metro system and the AC power system.
Determining the Attitudes of a Rural Community in Penang, Malaysia towards Mental Illness and Community-Based Psychiatric Care

Introduction: Historical attitudes toward mental illness have been one of stigmatisation. This has serious implications for patients as it disadvantages them in aspects of daily living and leads to delay in seeking and in defaulting treatment. Aim: The objective of this study was to determine the attitudes of a rural community in Penang, Malaysia towards various aspects of mental illness and towards community-based mental health facilities. Materials and Methods: A Malay version of Community Attitudes toward Mental Illness-Swedish (CAMI-S) questionnaire was used as a tool to achieve the objective of this ethically conducted cross sectional study. The results were analysed descriptively using PASW Statistics 18. Results: Most respondents felt that mental illness was unlike other illness (78.1%) and most did not trust mentally ill patients in remission to become babysitters (92.7%). However, majority of the respondents disagreed in treating the mentally ill as outcasts (78.1%). Most respondents (85.4%) also agreed that mental health treatment should be provided through community-based facilities where possible. Conclusion: While most respondents displayed a mixed feeling of distrust and fear but they also exhibited tolerance towards preventing stigmatisation and accepting community-based care for the mentally ill.
360 nW Gate-Driven Ultra-Low Voltage CMOS Linear Transconductor With 1 MHz Bandwidth and Wide Input Range

A low voltage linear transconductor is introduced. The circuit is a pseudo differential architecture that operates with ±0.2V supplies and uses 900nA total biasing current. It employs a floating battery technique to achieve low voltage operation. The transconductor has a 1MHz bandwidth. It exhibits a SNR = 72dB, SFDR = 42dB and THD = 0.83% for a 100mVpp 10kHz sinusoidal input signal. Moreover, stability is not affected by the capacitance of the signal source. The circuit has been validated with a prototype chip fabricated in a 130nm CMOS technology.
NGR-hTNF and doxorubicin in relapsed ovarian cancer (OC).

5059 Background: NGR-hTNF (asparagine-glycine-arginine human tumor necrosis factor) is able to promote antitumor immune responses and to improve the intratumoral doxorubicin (D) uptake by selectively damaging tumor vessels. Methods: OC patients (pts) with progressive disease (PD) after ≥ 1 platinum/taxane regimen and with a platinum free interval lower than 6 months (PFI <6) or ranging from 6 to 12 months (PFI 6-12) received NGR-hTNF (N) 0.8 µg/m2 and D 60 mg/m2 on day 1 every 3 weeks. Primary endpoint of this phase 2 trial was response rate by RECIST criteria with a target of ≥ 6/37 responding pts. Secondary aims were progression free survival (PFS) and overall survival (OS). Results: 37 pts (median age 57 years; PS 0/1 32/5; PFI < 6/6-12 25/12; prior regimens 1-5) were enrolled. Median baseline peripheral blood lymphocyte count (PBLC) was 1.6/mL (interquartile range 1.2-2.1). In all, 177 cycles were given, with 18 pts (49%) receiving ≥ 6 cycles and 12 pts (32%) 8 cycles. Neither grade 3/4 adverse events.
Driver Intervention Detection via Real-Time Transfer Function Estimation

Currently, the driver plays a crucial role in the safety of autonomous vehicles, functioning as the fall back for vehicle control systems. Fast and accurate detection of driver intervention is therefore of importance. In this article a novel driver intervention detection method for automated vehicles is presented and tested. Non-critical transitions are considered, excluding safety related applications. The transfer function between the electric power steering torque and steering column angle is estimated by perturbing the steering system with a known disturbance. This estimated value is used to detect whether a driver is intervening. The detection algorithm has been tested in simulations using a four degree-of-freedom vehicle model. The parameters of this vehicle model have been obtained via frequency response measurements performed on a test vehicle. Secondly, the performance of the algorithm has been tested with on-road measurements. The results show that driver intervention can be successfully detected within 0.4 seconds. The performance in terms of true and false detections has been analyzed, and the presented solution is shown to be robust to measurement noise and road disturbances.
Monocular SLAM Feature Point Optimization Based on ORB

— Simultaneous localization and mapping (SLAM) of mobile robots is a hotspot in the field of computer vision and intelligent robots. Through experiments on the monocular SLAM system indoors, the existence of problems was found that the map is sparse and feature point matches are mistaken in some environments. Therefore, it is proposed to optimize the feature point acquisition and match of the ORB algorithm, filter the feature points according to the actual hardware parameters, and perform image pre-processing on the mismatch problem generated after using the Hamming distance, and then obtain the improved RANSAC algorithm, more precise match points will be got. It makes the image matching in different environments possessing better robustness, and also improves the sparse problem of the construction of point cloud.
Effect of Pre-Sowing Seed Treatment with Plant Growth Regulators on Crop Growth Parameters of Blackgram (Vigna mungo L. Hepper)

The blackgram (Vigna mungo (L.) Hepper) also known as Vignamungo, black matpe bean, urid, urd, urd bean, udad dal, urad dal, or urad, is a crop that’s cultivated in Southern Asia. Blackgram is a major pulse in India that’s cultivated all over the country. This crop can be cultivated as a short duration pulse in the early monsoon season and in paddy fallows by utilising residual moisture. One of the major reasons that Indians love this crop is the fact that it improves the fertility of the soil by fixing atmospheric nitrogen content and is resistant to aberrant weather conditions. The seeds comprising 100 gram of seed will contain 3.6 per cent fat, 19 per cent carbohydrates, 3 per cent dietary fiber and 2025 per cent of protein. More importantly, blackgram plays a major role in the typical Indian diet, because it can serve as a supplement to a cereal-based diet and it International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 12 (2019) Journal homepage: http://www.ijcmas. com
The influence of covalent and non-covalent functionalization of GNP based nanofluids on its thermophysical, rheological and suspension stability properties

Covalent functionalization (CF-GNPs) and non-covalent functionalization (NCF-GNPs) approaches were applied to prepare graphene nanoplatelets (GNPs). The impact of using four surfactants (SDS, CTAB, Tween-80, and Triton X-100) was studied with four test times (15, 30, 60, and 90 min) and four weight concentrations. The stable thermal conductivity and viscosity were measured as a function of temperature. Fourier transform infrared spectroscopy (FTIR), thermo-gravimetric analysis (TGA), X-ray diffraction (XRD) and Raman spectroscopy verified the fundamental efficient and stable CF. Several techniques, such as dispersion of particle size, FESEM, FETEM, EDX, zeta potential, and UV-vis spectrophotometry, were employed to characterize both the dispersion stability and morphology of functionalized materials. At ultrasonic test time, the highest stability of nanofluids was achieved at 60 min. As a result, the thermal conductivity displayed by CF-GNPs was higher than NCF-GNPs and distilled water. In conclusion, the improvement in thermal conductivity and stability displayed by CF-GNPs was higher than those of NCF-GNPs, while the lowest viscosity was 8% higher than distilled water, and the best thermal conductivity improvement was recorded at 29.2%.
Sensitivity of climate models in relation to the “pool of inhibited cloudiness” over South of the Bay of Bengal

Realistic simulation of cloud variability and rainfall by the coupled models still remains a challenge particularly over the Asian Summer Monsoon (ASM). The simulation of the “pool of inhibited cloudiness” (hereafter referred to as PIC) and associated cloud variability have been analysed in the historical run of 26 models which participated in the Coupled Model Intercomparison Project Phase 5 (CMIP5) and it is shown that the current state of the art general circulation models (GCMs) still have difficulties in properly simulating the PIC. The pool covers an area greater than 1 million km2 between 3°–13°N and 77°–90°E over the southwest Bay of Bengal (BoB); persisting throughout the ASM and interestingly it is surrounded by the deep convective region. The majority of the models could not simulate cloud variability over the ASM. The performance of National Centre for Environmental Prediction (NCEP) Climate Forecast System (CFSv2) version 2.0, which is being used for operational monsoon prediction over the Indian region, is also tested to evaluate its fidelity in capturing PIC. The moist convective process in the default CFSv2 is found to be one of the major sources of uncertainty in its monsoon prediction. In this study, evaluation of the default CFSv2 (CTRL) and suites of modified CFSv2 have been carried out. The default version of CFSv2 has the simplified Arakawa Schubert (SAS) as convection scheme and Zhao and Carr (ZC) as microphysics. In another modification, the SAS is changed to revised simplified Arakawa Schubert (RSAS) keeping the microphysics unchanged. Further, a more physically based cloud scheme (WRF Single Moment 6‐class microphysics—WSM6) is used with SAS and RSAS for comparison of simulation of PIC. Among the CMIP5 models, ACESS‐1‐0, GFDL‐CM3, HadGEM2‐CC, HadGEM2‐ES are able to represent the PIC reasonably well. CFSCR has shown an improved fidelity in comparison to the CTRL, CTRL‐WSM and RSAS and other CMIP5 models. The impact of cloud microphysics in CTRL‐WSM and CFSCR appears to play an important role in the simulation of the PIC.
Active cell balancing of Li-Ion batteries using single capacitor and single LC series resonant circuit

In this paper a novel single series resonant tank and capacitor converter based voltage balancing circuit for series supercapacitor string and battery cells string is presented. It recognizes the balancing circuit which recovered the maximum energy and zero voltage gap between cells in a series supercapacitor system or battery system. This balancing circuit not only inherits the improvement of conventional single series resonant converter based balancing system, but also recovers the drawback of switching loss, conduction loss and voltage gap between cell strings. All MOSFET switches are controlled by a pair of complementary PWM signals. Also the resonant tank and parallel capacitor operate between the two mode of charging and discharging. This voltage balancing circuit has shown promising result to be used in battery management system.
Hyp-O-besity: Unmet Challenge in Management of Type 2 Diabetes Mellitus and Cardiovascular Risk

Glycaemic control is often disturbed by iatrogenic hypoglycaemia as a result of intensive treatment and can be a major barrier to optimal glycaemic management. This risk of hypoglycaemia acts like a deterrent to the patient from achieving euglycaemia. The fear of hypoglycaemia leads to “defensive snacking” which further disrupts achievement of euglycaemia and leads to weight gain. Obesity by itself carries a major risk for adverse cardiovascular outcomes and coupled with hypoglycaemia significantly increases the cardiovascular risk in patients with diabetes. “Hyp-obesity” is a new term that effectively conveys the present challenges in achieving euglycaemia due to hypoglycaemia and obesity and would help facilitate therapeutic strategies to optimise diabetes management. Newer drugs targeting the incretin pathway such as glucagon-like peptide-1 (GLP-1) mimetic and dipeptidyl peptidase-4 (DPP-4) inhibitors would be beneficial in minimising the risk of hypoglycaemia and obesity.
Nutritional intake and overall diet quality of female soccer players before the competition period

Objective: To assess the dietary intake and overall diet quality of female soccer players before the competitive games. Methods: This descriptive and cross-sectional study included 21 women aged 20.8±4.5 years from a professional soccer team. Their nutritional status and dietary adequacy during the training period, before competition season, were assessed. Dietary intake was assessed by three 24-hour recalls, one food frequency questionnaire, and the Healthy Eating Index, an overall diet quality index based on food group intake. Results: The athletes have shown proper nutritional status, but a diet deficient in energy due largely to low carbohydrate intake. On the other hand, the intakes of protein, fatty acids, and sodium were above the recommended intakes, even for athletes. Diet quality assessment by the Healthy Eating Index - 2010 resulted in a mean score of 54.6 points of a maximum of 100, indicating a need of improving the overall diet quality. Conclusion: The study found that the dietary patterns of female football players were both quantitatively and qualitatively inappropriate. A nutritional intervention is indicated to improve diet quality, with the inclusion of various foods, such as whole grains, fruits, vegetables, dairy products, and better protein quality, along with a reduction in saturated fats, sodium, and added sugar.
Computational soliton solutions to ( 2 + 1 ) -dimensional Pavlov equation using Lie symmetry approach

In this work, Lie symmetry analysis and one-dimensional optimal system for Pavlov equation are presented. All the possible vector ﬁelds, their commutative and adjoint relations are carried out under invariance property of Lie group theory. On the basis of optimal system, similarity reductions of Pavlov equation are obtained. A repeated process of similarity reductions transforms the Pavlov equation into ordinary differential equations, which generate invariant solutions. The obtained invariant solutions are supplemented by numerical simulation to analyse the physical behaviour. Thus, their parabolic, multisoliton, nonlinear, kink and antikink wave proﬁles are traced in results and discussions sections.
Implementation of Smoking Ban in Mental Hospitals： Views of Patients, Relatives and Staff

The Law on Tobacco Control of the Republic of Lithuania (issued in 1996) prohibits smoking in health care facilities. The security implementation is particularly problematic in psychiatric hospitals, where patients with adaptation problems are used to smoking feeling anxiety. Meanwhile, experts and scholars do not agree on the benefits or harm of smoking for individuals suffering from mental disorder. Republican Vilnius Psychiatric Hospital undertook an investigation of the attitudes of those mostly concerned—the patients, their relatives and the staff of the hospital, also of their views on the ways and feasibility to reduce smoking in the hospital. It was concluded that the main cause of patients’ smoking is addiction, and hospital staff recognize that mental disorders contribute to the increase in dependency. Other reasons—smoking reduces tension, facilitates adaptation to environments, enhances contacts. Most patients and their relatives believe that smoking should not be banned, while the staff believes it should be prohibited in part by a variety of increasing of constraints. The most effective means to reduce smoking in the hospital would be rich leisure activities, education and professional help.
Derrière le poumon, le cœur : effets cardiovasculaires de l'inhalation de substances irritantes ou d'allergènes

La Lettre du Cardiologue n° 344 avril 2001 12 n séminaire de travail du National Institute of Health américain a été organisé à Scottsdale (Phoenix, Arizona), réunissant des épidémiologistes, des pneumologues, des physiologistes et des pharmacologues. Les pneumologues ont depuis longtemps cherché à connaître les conséquences de l’inhalation de substances irritantes. Dès 1950, Pasteur Vallery-Radot et Dubois de Montreynaud avaient étudié en bronchoscopie les effets de l’inhalation d’allergènes (1). En 1985, les travaux de Boushey et du groupe de Nadel à San Francisco ont clairement fait apparaître le rôle de la pollution par l’ozone dans le déclenchement de crises d’asthme et ont largement contribué à orienter l’attention sur le rôle de l’inflammation dans l’hyperréactivité bronchique, ainsi qu’à stimuler le développement de l’utilisation thérapeutique des corticoïdes inhalés. Plus récemment, les effets de l’inhalation de particules-résidus de la combustion de moteurs Diesel ont également suscité de nombreuses études cliniques et expérimentales. C’est en raison de l’expérience physiopathologique acquise à propos de ces effets sur l’appareil respiratoire qu’une réflexion a été organisée conjointement par divers organismes pour envisager les effets cardiovasculaires et systémiques de l’inhalation de substances irritantes et allergéniques (American Thoracic Society, American Heart Association, Center for Disease Control, National Institutes of Health, et d’autres).