Miracle-dz/UniFAR-FTUs huggingface dataset:
Infer gene regulatory networks from time series data with formal methods

Reverse engineering of regulatory relationships from genomics data is emerging as crucial to dissect the complex underlying regulatory mechanism occurring in a cell. In this paper we propose a novel reverse engineering algorithm that makes use of formal methods, usually adopted in engineering to specify and verify concurrent software and hardware systems. With a formal specification of gene regulatory hypotheses we are able to prove mathematically whether a time course experiment belongs or not to the formal specification, determining in fact whether a gene regulation exists or not. The method is capable to detect both direction and sign (inhibition/activation) of regulations whereas most of literature methods which are limited to undirected and/or unsigned relationships. The method, empirically evaluated on experimental and synthetic datasets, reaches high levels of accuracy, outperforming literature methods in terms of precision and recall, despite the computational cost increases exponentially with the size of the network.
The Others Will Help: The Presence of Multiple Video Game Characters Reduces Helping After the Game Is Over

The bystander effect refers to the phenomenon that individuals are less likely to help if there are potential other helpers present. For instance, past research revealed that participants were less likely to help computer-controlled characters if there were other computer-controlled characters present. Research has also shown that the bystander effect occurs if the presence of others is merely imagined. The present research examined the idea that the presence of multiple characters within a video game reduces the player's helping behavior even after the video game is over. In fact, participants who played a video game with multiple characters present were less likely to devote time to assisting in a future study than participants who had played the same video game with only a single character present.
Internationalization of Education in India: Emerging Trends and Strategies

This article discusses the need and changing wants associated with internationalization of higher education in Indian context. The demand for international education is growing day by day. To cater these needs, institutions have started to take new steps. Besides traditional providers of higher education, new knowledge providers from business houses have started developing innovative models for delivery of higher education. India has certain advantages to expand its internationalization initiative and as a result receiving interests from foreign universities for setting up campuses in the country. India needs to have a policy towards private higher education including foreign universities desirous of setting up campus in India.
Effect of Trans Fatty Acids on Milk Fat and Their Impact on Human Health

Advances in our understanding of lipid metabolism in the ruminant and the effect of specific fatty acids on both ruminant metabolism and human health has increased significantly in recent years. Unique biohydrogenation intermediates formed in the rumen have been shown to be potent inhibitors of milk fat synthesis, and the biology behind this and its potential application and benefit to both animal welfare and animal productivity are active areas of research. In spite of the negative image of dietary trans fatty acids on human health, the two major trans fatty acids found in ruminant meat and milk, vaccenic acid and CLA, have been shown to be effective in preventing cancer and atherogenesis in biomedical studies with animal models. The enrichment of these fatty acids in milk by natural means offers potential to not only benefit human health but also improve the public perception of milk and dairy products.
Interaction of Learning Organization and Organizational Structure

Today organization is the constantly changing, flexi-ble, entrepreneur or similarly titled organization having the peculiar feature – the constant learning in individual, group or organizational level. Constant learning changes not only the enterprise but the employee and the staff as well. The employee should be acknowledged with the phi-losophical provisions of learning and the enterprise must ensure its staff suitable communication, self-realization and motivation system. Learning in individual, group and organizational level is the object of the research of many scientists (Wiegand, Senge, Nanoka, Levit, March et al (see Al-Laham, 2003)). The importance of individual and organizational culture for learning is especially stressed (Barney J.B., 1986;Sackmann S., 1992, much attention has been given to designing of motivation systems and other questions. But learning and the progress related with it, and changes proceed in specific surroundings where the per-son-organization is the main character but his/her activ-ity is limited or stimulated by the specific enterprise and the surrounding atmosphere. Every enterprise is organ-ized for some special technological process and this cre-ates some special structure based on labour functional division and specialization. This includes both production and service processes. This is the so called hard structure that often conflicts with requirements raised to learning-changing organization. The hard part of the organization is inert and it changes very slowly. Due to this the con-tradiction between the propagated theory and the actu-ally existing practice exists – the theory development does not find the necessary medium. One of such hard factors is the enterprise organiza-tional structures. Mintzberg H.(1976, 1983) paid consid-erable attention to their theoretical and practical aspects, new organizational structures were also investigated by Lithuanian authors such as Seilius A. , (1988) et al. But this problem is very often analyzed separately when the structural issues are revealed one-sidedly. This work discusses the development possibilities of organizational structures with the requirements of the quickly changing learning organization in mind.
New service development

The topic of new service development has been relatively neglected in the literature on innovation and new product development. This paper explores some of the similarities and differences between new product development and new service development. It outlines the typical stages of the new product development process and then suggests how new product development in service organisations may differ because of the characteristics of services like intangibility and inseparability.
Anti-4-1BB scFv immunogene therapy and low dose cyclophosphamide exhibit a synergistic antitumor effect in established murine lung tumors

T-cell costimulatory molecules such as 4-1BB may provide a distinct and important signal for promoting positive immune regulation. 4-1BB is thought to have potential use as a cancer immunotherapeutic drug. In our previous study, a nonreplicative adenovirus (Ad.4-1BB scFv) carrying single-chain Fv fragments (scFv) specific for the 4-1BB gene (anti-4-1BB scFv) possessed remarkable in vivo anti-hepatoma efficacy. However, monotherapy achieved by triggering 4-1BB signaling was not sufficient to induce eradicative anti-tumor activities in low immunogenic tumors. It is of great interest to explore any possible synergistic antitumor effect of 4-1BB signaling combined with low dose cyclophosphamide (CTX), which is well documented to inhibit the suppressive capability of regulatory T cells in mice and humans. In the present study, recombinant nonreplicative adenoviruses carrying an anti-4-1BB scFv gene were generated, characterized, and explored for their stimulation of anti-lung tumor (TC-1) immunity in immunocompetent C57BL/6 mice. Compared to adenovirus and cyclophosphamide alone, adenovirus-mediated anti-4-1BB scFv in combination with low dose CTX treatment could obviously augment the anti-tumor activity, in which some established TC-1 tumors were eradicated and the survival of mice was significantly extended. This synergistic antitumor effect could be largely attributed to the depletion of T regulatory cells induced by low dose CTX. These findings may provide a new and promising strategy for immunogene therapy against cancer.
Technique of collage for store design atmospherics

Purpose – The purpose of this paper is to analyze the holistic perception of the customer vis‐a‐vis the creation of an ideal store by using the projective technique of collage. In particular, it discusses the role of the factor of atmosphere which a distributor must privilege to satisfy the expectations of current customer.Design/methodology/approach – To this end, a qualitative exploratory survey based on the technique of collage has been carried out with a sample of 30 individuals. The information were collected through the drawings and the technique of “complete the following sentence”. The collages were analyzed using a holistic approach.Findings – The results show that the new customer refers to all the stimuli of the environment of purchase in order to satisfy his utility, hedonic and even social needs. The companies, and in particular the distributors, must direct the atmosphere of their store towards the vectors of attraction, gratification and distraction.Research limitations/implications – The p.
Study and Analysis of Standards of Five-Star Hotels Compared to the Dimensions of Luxury

A summary of the cognitive and emotional dimensions can lead to better understanding of the perception of a luxury hotel. This study confirms the idea that the perception of luxury value is influenced not only by the social purpose aussi by financial, functional and individual aspects. This study showed that the norms and standards of the hotels are not always synonymous with luxury. Therefore, an empirical study was done. This study shows that customers in the hospitality sector have different perceptions of luxury of five star hotels and that the standards of stars is not enough to be used in measuring the luxury of hotels.
Scoping Electronic Communication Privacy Rules: Data, Services and Values

We use electronic communication networks for more than simply traditional telecommunications: we access the news, buy goods online, file our taxes, contribute to public debate, and more. As a result, a wider array of privacy interests is implicated for users of electronic communications networks and services. This development calls into question the scope of electronic communications privacy rules. This paper analyses the scope of these rules, taking into account the rationale and the historic background of the European electronic communications privacy framework. We develop a framework for analysing the scope of electronic communications privacy rules using three approaches: (i) a service-centric approach, (ii) a data-centric approach, and (iii) a value-centric approach. We discuss the strengths and weaknesses of each approach. The current e-Privacy Directive contains a complex blend of the three approaches, which does not seem to be based on a thorough analysis of their strengths and weaknesses. The upcoming review of the directive announced by the European Commission provides an opportunity to improve the scoping of the rules.
Visual-evoked response produced by patterned light stimulus.

The photopic visual-evoked response (VER) produced by patterned stimuli was examined by changing: (1) the stimulus magnitude, (2) the contour density of the test pattern, and (3) the contour contrast. In the majority of normal subjects the VERs obtained by a grating pattern showed their maximum response at a relatively low level of stimulus magnitude. With a logarithmic increase in contour density of the test pattern, the response amplitude increased in almost linear fashion. The VERs to the multiple-hole pattern of different contrast showed an S-shaped increase of the amplitude with an increase of log contrast. The latency of these VERs showed very small change when contour density or contrast was changed. The results suggested that there were two different components in the VER. The one was due to the light sensitivity and the other was due to the contrast sensitivity in the visual system. The latter seemed to be dominant in the photopic VER.
Retail centre convenience: Its' influence over consumer patronage behaviour

The modern consumer seeks to maximise the value they derive from all their marketing exchanges. While there are two ways this can be achieved, current academic interest is typically focused on just one: increasing the hedonic benefits obtained from shopping. This study focuses on the other side of the equation: increasing value by decreasing the time, space and effort costs of shopping. Utilising a survey of consumer households, this study examines the importance of convenience in a multi-purpose shopping context. Analysis revealed that consumers prefer and visit most frequently, the retail form they consider most convenient. Moreover, the greater the convenience they associate with an attribute, the greater the importance they assign to it.
Green manufacturing practices in the fashion supply chain: lessons from Italian case studies

Companies are forced to undertake initiatives fitting within the scope of a green strategy, notwithstanding only a few of them dedicate their attention to environmental issues. The paper aims at exploring green manufacturing practices in the Italian fashion industry, by answering these research questions: To what extent are green manufacturing practices implemented among Italian fashion companies? Which are the reasons for embracing environmentally friendly practices? Are stakeholders conscious of environmental issues? A questionnaire was designed and used as a guideline for 15 case studies. From the analysis of the case studies, the main reasons why there is still a limited attention paid to environmental issues and some key guidelines for the implementation of green manufacturing practices in the fashion industry were identified. Findings provide managers with a picture of the adoption of environmental friendly practices, as well as with some useful guidelines for companies wishing to undertake environmental initiatives.
Developing an intranet towards knowledge sharing : a practitioner-based inquiry

The intranet is a common feature in many organizations. With the increasing use of a technology infrastructure in organizations, there is a continued challenge for employees in an organization to contribute their knowledge willingly and to make use of knowledge sharing with other employees. Intranets are well-suited for use as a strategic tool in knowledge sharing due to their ability to support the distribution, connectivity and publishing of data and information. Intranets should be seen as integral to an organization’s knowledge management strategy and should be tailored to suit and enhance an organization’s knowledge-sharing activities. The question arises: To what extent does an organization’s existing intranet facilitate knowledge sharing? From a practitioner-based inquiry perspective, this question was explored by the selection of a large organization – eThekwini Municipality, Durban, South Africa – as the field of application. Derived from a mixed methodology approach, the results of a survey are presented. It is suggested that encouragement be given for more practitioner-based inquiry research.
Taxation as a Driver for Designing Hybrid Securities

Changes in 2001 to the tax laws for Hybrid securities occurred at the same time as proposed accounting, regulatory and ratings agency changes for those types of securities. The tax law changes appear to have had their intended effect on the targeted Hybrid securities, Income Securities, but it also appears that the design of Hybrid securities following those changes owes more to the accounting, regulatory and other changes that were occurring than to the changes in the tax laws.
Increased Documented Brief Alcohol Interventions With a Performance Measure and Electronic Decision Support

BackgroundAlcohol screening and brief interventions (BIs) are ranked the third highest US prevention priority, but effective methods of implementing BI into routine care have not been described. ObjectivesThis study evaluated the prevalence of documented BI among Veterans Affairs (VA) outpatients with alcohol misuse before, during, and after implementation of a national performance measure (PM) linked to incentives and dissemination of an electronic clinical reminder (CR) for BI. MethodsVA outpatients were included in this study if they were randomly sampled for national medical record reviews and screened positive for alcohol misuse (Alcohol Use Disorders Identification Test-Consumption score ≥5) between July 2006 and September 2008 (N=6788). Consistent with the PM, BI was defined as documented advice to reduce or abstain from drinking plus feedback linking drinking to health. The prevalence of BI was evaluated among outpatients who screened positive for alcohol misuse during 4 successive phases of BI implementation: baseline year (n=3504), after announcement (n=753) and implementation (n=697) of the PM, and after CR dissemination (n=1834), unadjusted and adjusted for patient characteristics. ResultsAmong patients with alcohol misuse, the adjusted prevalence of BI increased significantly over successive phases of BI implementation, from 5.5% (95% CI 4.1%-7.5%), 7.6% (5.6%-10.3%), 19.1% (15.4%-23.7%), to 29.0% (25.0%-33.4%) during the baseline year, after PM announcement, PM implementation, and CR dissemination, respectively (test for trend P<0.001). ConclusionsA national PM supported by dissemination of an electronic CR for BI was associated with meaningful increases in the prevalence of documented brief alcohol interventions.
Staging of α‐synuclein in the olfactory bulb in a model of Parkinson's disease: Cell types involved

Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes α‐synucleinopathy in the olfactory bulb at an earlier stage (Braak's stage1) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by α‐synuclein in the olfactory bulb of transgenic mice (2–8 months of age) expressing the human A53T variant of α‐synuclein. α‐Synuclein immunostaining progressively affects interneurons and mitral cells. Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic‐ and calcium binding protein‐positive cells are severely affected. This temporal evolution and the cell types expressing α‐synuclein are reminiscent of idiopathic Parkinson's disease and support the usefulness of this model to address specific topics in the premotor phase of the disease. © 2010 Movement Disorder Society
A Review of Thai Knowledge Management Practices: An Empirical Study

The objective of this empirical study is to review current knowledge management (KM) practices in Thailand, and in particular to explore the knowledge sharing maturity and capability of Thai organizations and their readiness to embrace a knowledge creation culture. The survey focuses on a number of organizations drawn from an established taxonomy of organizations in Thailand using the stratified random sampling technique. The results indicate that (a) there is an established knowledge sharing culture supported by a corporate KM strategy, amongst high-tech organizations, as well as a preparedness for change to migrate to a knowledge creation culture; (b) a number of international organizations exhibit ad-hoc knowledge sharing practices as well as a growing awareness about the value of knowledge sharing and what can be termed as intangible assets; (c) a clear lack of any knowledge-oriented practice within ministry and department of public sectors. This empirical study provides a foundation to further the research and develop a framework for Thai organizations that promotes adoption of knowledge sharing practices as well as the migration from a knowledge sharing to a knowledge creation model.
Hypouricemic effect of the methanol extract from Prunus mume fruit in mice

Context: The fruit of the Prunus mume Sieb. et Zucc (Rosaceae) is used as a health food or medicinal material in traditional herb medicine for a long time in Eastern Asian countries. Objective: Our present study investigated the hypouricemic effect of the methanol extract from P. mume fruit (MPMF) in mice with potassium oxonate-induced hyperuremia. Materials and methods: Effect of MPMF (35, 70 and 140 mg/kg, p.o.) administrated for 7 days on the serum, liver, urinary uric acid levels and liver xanthine oxidase (XO) activity were assessed in mice. Results: Hyperuricemic mice induced by potassium oxonate demonstrated an elevation in serum and liver uric acid levels (11.0 mg/dL and 0.52 mg/g tissue) and a reduction in urinary uric acid levels (49.9 mg/dL). Oral administration of 140 mg/kg MPMF for 7 days reversed the abnormalities in serum, liver and urinary uric acid levels (7.1 mg/dL, 0.37 mg/g tissue and 69.7 mg/dL, respectively). In addition, 70 and 140 mg/kg MPMF (3.1 and 2.9 nmol/min per mg protein) inhibited liver XO activity compared with hyperuricemic mice (3.9 nmol/min per mg protein). Discussion and conclusion: The results indicated that the beneficial hypouricaemic effect of MPMF may be mediated, at least in part, by inhibiting XO activity in the liver. Our study suggests that P. mume and its extracts may have a considerable potential for development as an anti-gout agent for clinical application.
Information Security Awareness and Practices In Malaysian IHLs: A Study at UNISEL

Securing information is essential for safeguarding an organization business operation since information is a valuable asset for the organization. One of the most vital information security controls is information security awareness and practice. The purpose of this study is to assess the levels of information security awareness and practice among faculty staffs in Malaysian IHLs. The survey questionnaire was distributed to faculty staffs in University Selangor as a sample study to assess the trend of information security awareness and practice. The finding of the study shows that more than half of them were aware of the importance of information security in educational learning environment. This research is expected to contribute to information security awareness in IHLs. This research recommends that an information security policy should be developed for Malaysian IHLs. This study will enable FCSIT and Centre of ICT at UNISEL to evaluate their information security training programs and their computer and information security policies. This research is important to create awareness and propose action to ensure the staff can protect their information resources and protect their people from any information security attacks. This article describes information security issues and describes information security in Malaysia IHLs. It discusses the methodology and finding of the study. This research shows that IHLs should take proactive steps to encounter this information security attack and challenges.