Miracle-dz/UniFAR-FTUs huggingface dataset:
Objective assessment of perceived age reversal and improvement in attractiveness after aging face surgery.

IMPORTANCE Primary reasons why patients pursue aesthetic facial surgery are to look younger and more attractive; however, there is minimal literature about the effect of aesthetic facial surgery on perceived age and attractiveness. OBJECTIVES To objectively and quantitatively evaluate the degree of perceived age change and improvement in attractiveness following aesthetic facial surgical procedures. DESIGN Prospective evaluation by independent raters of preoperative and postoperative photographs of 49 consecutive patients who underwent aesthetic facial surgery between July 4, 2006, and July 22, 2010. The photographs of these patients were presented to 50 blinded raters, each of whom was randomly assigned to 4 rater groups. Raters were asked to estimate the age of each patient in the photographs presented and to rate the patient's attractiveness on a scale of 1 to 10. SETTING Facial plastic surgery private practice in Toronto, Ontario, Canada. PARTICIPANTS Patient inclusion criteria consisted of primary facial surgical procedures with a minimum 6-month follow-up period, use of standardized photographs, and no cosmetic procedures in the intervening period. Raters were chosen from the province of Ontario, randomly assigned to 1 of 4 rater groups, and blinded to the objectives of the study. MAIN OUTCOMES AND MEASURES The mean "years saved" (true age minus guessed age) and change in attractiveness scores after facial aesthetic surgery. RESULTS The mean overall years saved following aesthetic facial surgery was 3.1 years (range, -4.0 to 9.4 years). There was a small but insignificant increase in attractiveness scores in postprocedural photographs relative to preprocedural photographs (P > .54). CONCLUSIONS AND RELEVANCE In this study, aesthetic facial surgery was effective in reducing the apparent age of patients but did not consistently improve their attractiveness. LEVEL OF EVIDENCE 4.
Fotoprotetores naturais no contexto da saúde pública brasileira

O principal fator desencadeador do câncer de pele e a exposicao a radiacao ultravioleta proveniente do sol. A prevencao desta patologia inclui acoes simples como a protecao contra a luz solar, uma medida efetiva e de baixo custo, cuja forma mais difundida e a aplicacao de protetores solares na pele. O mercado de fotoprotetores tem crescido num ritmo de 21% ao ano, o que indica a grande procura dos consumidores por este tipo de produto. Pesquisas tem sido extensivamente realizadas com o intuito de desenvolver protetores solares baseados em produtos naturais, pelo fato de causarem menos efeitos colaterais e serem menos agressivos ao meio ambiente. Neste trabalho, foi dado um enfoque em como os fotoprotetores naturais podem ser um importante instrumento para a saude publica brasileira.
Utility of a pneumonia severity index in the optimization of the diagnostic and therapeutic effort for community-acquired pneumonia

The objective was to evaluate the utility of the Pneumonia Severity Index (PSI) developed by Fine et al. as a tool to streamline diagnostic and therapeutic effort. Site of care of patients was recommended in accordance with the PSI class: classes I and II underwent treatment at home and classes III, IV, and V were hospitalized. Class I comprised 37 patients; class II had 30, class III had 20, class IV had 31, and class V had 10 patients. 80 patients were admitted into the hospital, 3 of whom required admittance to the intensive care unit, and 48 were managed as outpatients from the emergency room. Overall mortality was 4 patients (3.1%). Of these, 3 belonged to class IV and 1 to class V. The aetiological diagnosis was obtained in 53.9% of the cases (69/128). If classes I to III are analysed together, the percentage of aetiological diagnoses was 47% (41/87), increasing to 68% (28/41) for patients in classes IV and V. In our experience Fine's PSI classification, with rationalization and adaptation to the particularities of each centre, is an effective tool for deciding on hospitalization for selecting the most suitable battery of diagnostic tests based on cost-benefit criteria. However, it is inadequate for young patients with hypoxia or pleural effusion. Therefore, although hospitalization of patients with pneumonia should be mainly based on clinical criteria, Fine's PSI classification could help physicians in making more rational decisions in this respect.
Toll‐like receptor (TLR) expression and TLR‐mediated cytokine/chemokine production by human uterine epithelial cells

The objective of this study was to examine the expression of toll‐like receptors (TLRs) by the uterine epithelial cell line ECC‐1 and to determine if stimulation of the expressed TLRs induces changes in cytokine and/or chemokine secretion. The expression of TLR1 to TLR9 by ECC‐1 cells was demonstrated by reverse transcription polymerase chain reaction, with only TLR10 not being expressed. Stimulation of ECC‐1 cells using agonists to TLR2, TLR4 and TLR5 induced the expression of the chemokines interleukin‐8 (IL‐8) and monocyte chemotactic protein‐1 (MCP‐1), as well as the pro‐inflammatory cytokine IL‐6, and occurred in a dose‐dependent manner. In response to zymosan and flagellin, pathogen‐associated molecular patterns (PAMP) that are recognized by TLR2 and TLR5 respectively, ECC‐1 cells secreted significantly more IL‐8, MCP‐1 and IL‐6 than in response to other TLR agonists. In contrast, agonists to TLR3, TLR7, and TLR9 had no effect on the secretion of the 13 cytokines or chemokines analysed. These results indicate that uterine epithelial cells are important sentinels of the innate immune system. Further it indicates that all but one of the known TLRs are expressed by ECC‐1 cells and that stimulation through specific TLRs mediates changes in the expression of key chemokines and pro‐inflammatory cytokines that aid in the defence of the uterus against potential pathogens.
Mixture of deep CNN-based ensemble model for image retrieval

This paper proposes an aggregate (or mixture) of ensemble models for image retrieval based on deep Convolutional Neural Networks (CNN). It utilizes two kinds of deep learning networks, AlexNet and Network In Network (NIN), to obtain image features, and to compute weighted average feature vectors for image retrieval. Based on experimental results, the aggregate ensemble architecture effectively enhances learning with higher accuracy than single CNN in image classification. When the proposed aggregate of deep CNN-based ensemble model is applied to CIFAR-10 and CIFAR-100 datasets, it is shown to achieve 0.867 and 0.526 mean average precision in image retrieval, respectively.
Apoptosis in colorectal tumour cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate

The short chain fatty acids acetate, propionate and butyrate are produced when dietary fibre is fermented by the colonic bacteria. We have previously shown that sodium butyrate induces apoptosis in 3 colorectal tumour cell lines. We have extended our study to 3 adenoma and 4 carcinoma cell lines and investigated whether propionate and acetate also induce apoptosis. All 3 short chain fatty acids induced apoptosis at physiological concentrations, but of the 3, butyrate was the most effective. Since these fatty acids are produced as a result of bacterial fermentation of dietary fibre, this may in part explain the correlation between a high‐fibre diet and low colorectal cancer incidence. Sodium butyrate induced apoptosis in all 7 of the cell lines studied; however, 2 of the 4 carcinoma cell lines (PC/JW/F1 and S/KS/F1) were more resistant to butyrate‐induced apoptosis than the 3 adenoma cell lines, suggesting that at least some carcinomas may evolve mechanisms to protect the cells from the induction of apoptosis. The bile acid deoxycholic acid has previously been reported as a possible tumour promoter in the large intestine and its levels are reduced by dietary fibre. Concentrations of between 10 nM and 0.1 mM had no effect on either the proliferation or apoptosis of colonic tumour cells in vitro. However, a significant induction of apoptosis was obtained at a concentration of 0.5 mM. These results may have significance for the aetiology of colorectal cancer. © 1995 Wiley‐Liss, Inc.
A naked ape would have fewer parasites

Unusually among the mammals, humans lack an outer layer of protective fur or hair. We propose the hypothesis that humans evolved hairlessness to reduce parasite loads, especially ectoparasites that may carry disease. We suggest that hairlessness is maintained by these naturally selected benefits and by sexual selection operating on both sexes. Hairlessness is made possible in humans owing to their unique abilities to regulate their environment via fire, shelter and clothing. Clothes and shelters allow a more flexible response to the external environment than a permanent layer of fur and can be changed or cleaned if infested with parasites. Naked molerats, another hairless and non-aquatic mammal species, also inhabit environments in which ectoparasite transmission is expected to be high, but in which temperatures are closely regulated. Our hypothesis explains features of human hairlessness—such as the marked sex difference in body hair, and its retention in the pubic regions—that are not explained by other theories.
Sexual dysfunction in infertile women

Background: Sexual problems have different effects on the life of people by influencing their interpersonal and marital relationships and satisfaction. Relationship between sexual dysfunctions and infertility can be mutual. Sexual dysfunction may cause difficulty conceiving but also attempts to conceive, may cause sexual dysfunction. Objective: This paper compares sexual dysfunction in fertile and infertile women. Materials and Methods: In this cross-sectional study, 110 infertile couples referring to Montasarieh Infertility Clinic and 110 fertile couples referring to five healthcare centers in Mashhad were selected by class cluster sampling method. Data collection tools included demographic questionnaire and Glombok-Rust Inventory of Sexual Satisfaction. Data were analyzed through descriptive and analytical statistical methods by SPSS. Results: There was no significant difference in total score of sexual problems and other dimensions of sexual problems (except infrequency) in fertile 28.9 (15.5) and infertile 29.0 (15.4) women. Fertile women had more infrequency than infertile women (p=0.002). Conclusion: There was no significant difference between fertile and infertile women in terms of sexual problems. Paying attention to sexual aspects of infertility and presence of programs for training of sexual skills seems necessary for couples.
Linguagens documentárias e vocabulários semânticos para a web

A Web atual continua a oferecer deficiencias quando a recuperacao de informacao. Assim o demonstra a presenca persistente de sobrecarga informativa, a ineficacia das palavras-chave quando se pretende fazer recuperacoes precisas, a desordem terminologica consequente da falta de autoridade literaria ou a ausencia cronica de sistemas com PLN. Com ideia de superar estas limitacoes, a ultima decada teve um crescimento e uma adaptacao intensa dos vocabularios e das linguagens que organizam o conhecimento. A sua estrutura e a sua complexidade ficam determinadas pelo uso de lexico alargado, contando inclusive com estruturas verbais, pela ampliacao das relacoes existentes entre os seus componentes, pela superacao da referencia a objetos do pensamento e objetos do mundo, enfim, pelo emprego de estruturas logicas e de mapas conceituais para uma organizacao dos documentos cada vez mais complexa.
Efﬁcient Numerical Solution of PIDEs in Option Pricing

The estimation of the price of different kinds of options plays a very important role in the development of strategies on financial and stock markets. There many books and various papers which are devoted to the exist mathematical theory of option pricing. Merton and Scholes became winners of a Nobel Prize in economy who described the basic concepts of the mathematical theory development. In this thesis a review of the basic numerical methods for option pricing including the treatment of jumps is given. These methods are compared and numerical results are presented.
Sodium effect of growth on aspartate and genetic analysis of a Bacillus subtilis mutant with high aspartase activity

Most strains of Bacillus subtilis, dervied from the 168 (Marburg) strain, grow slowly on aspartate as sole carbon source. We isolated a mutant (aspH) that grows rapidly on aspartate because it produces aspartase constitutively. Thus, aspartase is needed for rapid growth on aspartate, whereas aspartate-alpha-ketoglutarate aminotransferase is not needed, as was demonstrated by a mutant lacking that enzyme activity. By two--and three-factor crosses using PBSl transduction, the aspH mutation was located between the aroD and the lys markers of the genetic map. Although sodium ions do not affect growth on glucose or L-malate, they specifically stimulate growth on aspartate in both the parent and the aspH mutant strains. Enzyme activities of crude aspartase and fumarase and of purified aspartase do not increase in the presence of sodium. These results show that stimulation by sodium involves some reaction other than the enzymes catabolizing aspartate. The ease of purification from the aspH strain and the stability of aspartase suggest that the B. subtilis enzyme is particularly useful for aspartate determinations.
Adaptive modulation for OFDM systems using space-frequency block codes

This paper presents a new approach to adaptive modulation for OFDM using Space-Frequency Block Codes. In the proposed scheme, the benefits of adaptive modulation, space-frequency block codes (SFBC) and OFDM are exploited to provide high quality of data transmission over multipath fading channels. When the channel state information is known at the transmitter, a large gain over non-adaptive system can be obtained. The performance of the proposed system is eval- uated and compared with non-adaptive systems. We show that the proposed adaptive modulated SFBC-OFDM, has superior performance compared to non-adaptive systems.
Single-mode photonic crystal fiber with low bending loss and Aeff of > 200 μm2 for ultra high-speed WDM transmission

We propose photonic crystal fiber with W-shaped effective index profile to achieve the largest A<sub>eff</sub> for telecommunication use. We realized a 220-μm<sup>2</sup> A<sub>eff</sub> with a cut-off wavelength and bending loss compatible with ITU-T recommendation G.655.
The Chimpanzee's Mind: How Noble in Reason? How Absent in Ethics?

Morality and ethics in humans are generally understood by sociobiologists in the same tenns as altruism in other animals. According to this perspective, altruism exists because it confers a net reproductive advantage, either through kin selection or reciprocity, on those genes that support it. Thus, the theory of inclusive fitness allows sociobiologists to describe altruistic and ethical behaviors as genetically selfish even if they are individually generous. The position of sociobiologists is clear: When individuals behave in ways that put their own survival and reproduction at risk for the benefit of others, those costs must be genetically recouped.
Nut consumption for the primary prevention of cardiovascular disease.

BACKGROUND Nuts contain a number of nutritional attributes which may be cardioprotective. A number of epidemiological studies have shown that nut consumption may have a beneficial effect on people who have cardiovascular disease (CVD) risk factors. However, results from randomised controlled trials (RCTs) are less consistent. OBJECTIVES To determine the effectiveness of nut consumption for the primary prevention of CVD. SEARCH METHODS We searched the following electronic databases: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Web of Science Core Collection, CINAHL, Database of Abstracts of Reviews of Effects (DARE), Health Technology Assessment Database (HTA) and Health Economics Evaluations Database (HEED) up to 30 July 2015. We searched trial registers and reference lists of reviews for further studies. We did not apply any language restrictions. SELECTION CRITERIA We included RCTs of dietary advice to increase nut consumption or provision of nuts to increase consumption lasting at least three months and including healthy adults or adults at moderate and high risk of CVD. The comparison group was no intervention or minimal intervention. The outcomes of interest were CVD clinical events and CVD risk factors. DATA COLLECTION AND ANALYSIS Two review authors independently selected trials for inclusion, abstracted the data and assessed the risk of bias in included trials. MAIN RESULTS We included five trials (435 participants randomised) and one ongoing trial. One study is awaiting classification. All trials examined the provision of nuts to increase consumption rather than dietary advice. None of the included trials reported on the primary outcomes, CVD clinical events, but trials were small and short term. All five trials reported on CVD risk factors. Four of these trials provided data in a useable format for meta-analyses, but heterogeneity precluded meta-analysis for most of the analyses. Overall trials were judged to be at unclear risk of bias.There were variable and inconsistent effects of nut consumption on CVD risk factors (lipid levels and blood pressure). Three trials monitored adverse events. One trial reported an allergic reaction to nuts and three trials reported no significant weight gain with increased nut consumption. None of the included trials reported on other secondary outcomes, occurrence of type 2 diabetes as a major risk factor for CVD, health-related quality of life and costs. AUTHORS' CONCLUSIONS Currently there is a lack of evidence for the effects of nut consumption on CVD clinical events in primary prevention and very limited evidence for the effects on CVD risk factors. No conclusions can be drawn and further high quality longer term and adequately powered trials are needed to answer the review question.
Enhancing Java server availability with JAS

The Java programming language is increasingly used in the implementation of servers with stringent availability, reliability, and performance requirements. Our Java Application Supervisor (JAS) software system is an attachment to a Java runtime environment that enhances the availability of a target Java program. To this end, JAS automatically detects and resolves certain reliability and performance problems during the execution of the target program. JAS does not require any source or byte code modifications in the target program. Instead, JAS is configured for a target program by supplying simple policies that determine how JAS reacts to problems during the target program execution. JAS typically imposes little execution time and memory overhead on the target program. We describe an experiment with a Web proxy that exhibits reliability and performance problems under heavy load. In this experiment, running the proxy in conjunction with JAS increased the rate of successful requests to the proxy by 33% and decreased the averagerequest processing time by 22%. JAS was also used successfully in two Java servers at Bell Labs to monitor server reliability and performance and ensure long‐term availability. Copyright © 2001 John Wiley & Sons, Ltd.
Protein tyrosine phosphatases as drug targets: PTP1B and beyond

Protein tyrosine phosphatases (PTPs) control signal transduction pathways and have recently emerged as potential drug targets. Inhibition of individual PTPs can result in the activation of therapeutically relevant kinase cascades. This is particularly useful in cases where disease is associated with hormonal resistance, such as insensitivity to insulin or leptin. Currently, PTP1B is being investigated by a number of companies as a promising target for leptin/insulin mimetics and in the treatment of diabetes and obesity. Since all 90 – 100 PTPs have been identified in the human genome, the challenge now is to identify the function of these enzymes and the therapeutic indications that may exist for specific PTP inhibitors.
Empresa como sistema adaptativo complejo y gestión de la complejidad Enterprise as a complex adaptive system management complexity

El presente trabajo busca identificar a la empresa como un sistema adaptativo complejo (CAS,por su sigla en ingles Complexity Adaptative Systems), y como se gestiona la complejidad, para poder afrontarla. Para tal fin, se revisan resultados de investigacion publicados en revistas academicas que han facilitado la introduccion de las ciencias de la complejidad en la administracion. Al igual que variada bibliografia y publicaciones que trabajan en el tema. El trabajo es desarrollado considerando a la empresa como sistema adaptativo complejo, asi como, los efectos de la complejidad en ellas y como estos pueden ser abordados.
College Enrollment Patterns for Rural Indiana High School Graduates.

• A similar proportion of 2010 Indiana graduates of rural and of nonrural public high schools enrolled in college, but the proportion that enrolled in a two-year college was higher for graduates of rural schools. • Rural graduates had academic preparation similar to that of nonrural graduates and were less likely to be eligible for the school lunch program. • Rural graduates travelled farther than nonrural graduates to attend two-year colleges and less selective four-year colleges. • About a third of rural graduates and a quarter of nonrural graduates who enrolled in college chose a college that was less selective than colleges for which they were presumptively eligible.
Quality Assessment of Platelet Concentrates Prepared after Whole Blood Overnight Storage

The present study focuses to assess the in vitro effect on quality of platelet concentrates (PCs) prepared from overnight-held whole blood (WB). Method: Thirty four units of WB were stored overnight at 20 to 24oC and processed on the following day, and 30 units of WB were processed immediately. Result: The volume of PCs from overnight-held WB on Day 1 was significantly lower. On the same day, the PCs were significantly lower in platelet count but by Day 3 and Day 5, the difference was disappeared. PCs made from overnight-held WB had a significantly higher total red blood count on Day 1, Day 3 and Day 5, and for total white blood count was significantly higher on Day 5. pH was significantly lower on Day 1, Day 3 and Day 5. Sterility test for both groups of PCs give negative results. Conclusion: PRP-derived PCs from overnight-held WB have significantly different in vitro variables as from freshly processed WB. However, based on one-sample t-test comparison with the quality requirement of PCs, the use of the PCs from overnight-held WB was possible as the results of volume, platelet count and pH were significantly higher than the quality requirement and specification. 