Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical efficacy of omega-3 polyunsaturated fatty acids and rosuvastatin in combination therapy for patients with psoriasis and metabolic syndrome

Based on the examination and treatment of 100 patients with moderate psoriasis associated with metabolic syndrome, it was established that the use of narrowband UVB-therapy combined with rosuvastatin and omega-3 polyunsaturated fatty acids in combination therapy contributes to the improvement of the efficacy of therapy for dermatosis, induces a long-term remission and improves the life quality of patients.
Tumore naso-sinusale ed esposizione recente a polveri di legno / Sinonasal cancer and recent exposure to wood dust

Egregio Direttore,riteniamo interessante comunicare ai lettori un caso di tumore naso-sinusale (TuNS), nella fattispecie un carcinoma dell’etmoide scarsamente differenziato a piccole cellule, manifestatosi a seguito di pregressa, ma relativamente recente, esposizione a polveri di legno. L’Agenzia Internazionale per la Ricerca sul Cancro (IARC) classifica le polveri di legno come cancerogeni per l’uomo sulla base, in particolare,dell’associazione tra esposizione occupazionale e insorgenza di TuNS di cui l’istotipo maggiormente rappresentato e l’adenocarcinoma sottotipo intestinale (9, 14). [. ]
La Heterogeneidad de los Servicios Intensivos en Conocimiento: El Caso de Argentina

El presente articulo busca contribuir al debate acerca de la heterogeneidad entre los servicios intensivos en conocimiento (SIC), sobre la base de una fuente de informacion novedosa que nos permite no solo estudiar las caracteristicas de los SIC a un mayor nivel de desagregacion que el utilizado comunmente en la literatura internacional, sino tambien analizar estas actividades en el marco de un pais en desarrollo como la Argentina. Mediante una combinacion de tecnicas de analisis multivariado obtenemos una tipologia empirica que nos brinda una vision mas clara sobre los puntos en comun y las diferencias entre los distintos tipos de SIC identificados. Esta contribucion no solo es util para el mejor analisis de estos sectores, que han ganado fuerte peso en la economia global, sino tambien para los tomadores de decision, ya que son muchos los paises que estan implementando politicas de desarrollo productivo dirigidas a los SIC.
Review of Within Our Grasp: Achieving Higher Admissions Standards in Teacher Prep

Based on a review of GPA and SAT/ACT requirements at 221 institutions in 25 states, a new report from the National Council on Teacher Quality (NCTQ) recommends that states, institutions of higher education, and the Council for the Accreditation of Educator Preparation (CAEP) maintain or establish a higher bar for entry into teacher preparation programs. The NCTQ report suggests that boosting teacher candidate entry requirements in ways they advocate would significantly improve teacher quality in the U.S. Yet the report does not provide the needed supports for its assertions or recommendations. In addition, the report makes multiple unsupported and unfounded claims about the impact on teacher diversity of raising admissions requirements for teacher candidates, about public perceptions of teaching and teacher education, and about attracting more academically able teacher candidates. Each claim is based on one or two cherry-picked citations while ignoring the substantial body of research that either provides conflicting evidence or shows that the issues are much more complex and nuanced than the report suggests. Ultimately the report offers little guidance for policymakers or institutions. Review of Within Our Grasp: achievinG hiGher admissiOns standards in teacher prep
The Effect of Lidocaine Enriched Cardioplegia on Myocardial Ischemia-Reperfusion Injury

1 Emin Can Ata1, Yüksel Dereli2, Kadir Durgut2, Cevat Özpınar3 1Özel İMC Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Mersin, 2Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kalp ve Damar Cerrahisi AD, Konya, 3Özel Farabi Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Konya, Türkiye Lidocaine Enriched Cardioplegia The Effect of Lidocaine Enriched Cardioplegia on Myocardial Ischemia-Reperfusion Injury
Activities of daily living amongst inmates of home for aged in Nagpur, Maharashtra, India: a cross sectional study

Background: Although persons of all ages may have problems performing the Activities of Daily Living (ADL), prevalence rates are much higher for the elderly (65 years and over) than for the non-elderly. Elderly population face many problems. They become economically dependent on family for their basic needs and health care. Due to nuclear family norm, there is no place for elderly parent who feel alone and insecure. The study was undertaken to assess activities of daily living and reasons for admitting in home for aged amongst them. Objectives of present study were to assess the activities of daily living (ADL) and to identify the reasons for admitting in home for aged, in two homes for aged in Nagpur city, Central India. Methods: A cross sectional study was undertaken in two homes for aged namely Panchvati Vridhashram, Umred road and Home for aged, Untakhana, Nagpur, Maharashtra, India. Total 176 study subjects had consented for participation in study. Results: Mean age of study subjects was 73.47±6.06 year ranging from 61 to 90 years. Proportion of female inmate was 55.11%. Around one-fifth of study subjects (19.32%) were illiterate. Significantly more illiterate study subjects were of female gender (chi- square=5.78, d.f.=1, P=0.016). Mean duration of stay in home for aged was 5.29±3.29 years with the range of 9 months to 17 years. Number of study subject’s dependent for at least one ADL was 37 (21.02%). Amongst dependents 32 (18.8%) inmates were partially dependent with ADL score of 1-5 and only 5 (2.85%) inmates were totally dependent with ADL score of 6-12. The proportion of inmates with dependency for at least one activity of activities of daily living increases as the age increases. Positive liner trend was observed between age and dependency (r=0.1971, P=0.0087). Conclusions: Prevalence of ADL dependency was 21.02% among the inmates of home for aged. Dependency for activities of daily living increases with increase in age. Major reasons for admission to the home for aged were - no one to look after, strained relation with family members and economic constraints. There is need for economic assistance through social security to economically dependent inmates.
Restorative Yoga for Symptom Management in Fibromyalgia: Results of an 8-week Intervention

Objective: The aim of this study was to determine the feasibility of an 8-week restorative yoga intervention and to collect preliminary data on its effects on the fibromyalgia-related symptoms of chronic widespread pain, sleep disturbance, and fatigue, and health-related quality of life. In a mixed methods, single-arm, feasibility study, participants completed pre- and post-intervention semi-structured interviews and self-report assessments at baseline, weeks 4 and 8, and at a 1-month follow-up telephone interview. Results: In this group of participants (N = 12), recruitment, retention, and adherence rates were comparable to those of other fibromyalgia yoga studies: recruitment 57.14%; retention 75%; adherence to group class 87.5%; and home practice adherence 93.33%. A ratio of 1:2 yoga instructor to participants was required for the five-posture 90-minute class sequence as compared with a ratio of 1-2:10-25 yoga instructors to study participants reported in other fibromyalgia yoga studies. Statistically significant trends and minimal clinically important differences were found at week 8 when comparing participant baseline to week 8 self-report questionnaire scores for the Revised Fibromyalgia Impact Questionnaire total score (p = 0.01; 18.51%), the Pain Numeric Rating Scale for the subscales pain now (p = 0.04; 36.36%) and average pain over the past week (p = 0.04; 19.61%), the General Sleep Disturbance Scale total score (p = 0.04; 17.40%), and the Pittsburgh Sleep Quality Index total score (p = 0.02; 27.06%). Conclusion: Although the 8-week, five-posture, 90-minute restorative yoga group class was found not to be feasible as a symptom self-management strategy in this study, the findings support the need for further investigation of the home practice format. Future longitudinal, randomized, controlled trials of a restorative yoga home practice format to establish intervention efficacy and symptom-self management potential as well as those examining restorative yoga intervention resource utilization in persons with fibromyalgia are recommended
Avelumab (MSB0010718C; anti-PD-L1) in patients with advanced gastric or gastroesophageal junction cancer from JAVELIN solid tumor phase Ib trial: Analysis of safety and clinical activity.

4009Background: Avelumab (proposed INN) is a fully human anti-PD-L1 IgG1 antibody under clinical investigation in multiple cancers. We report safety and clinical activity of avelumab as a first-line maintenance (Mn) or second-line (2L) therapy in patients (pts) with advanced gastric or gastroesophageal junction cancer (GC/GEJ; NCT01772004), including activity associated with PD-L1 expression. Methods: Pts with GC/GEJ received avelumab at 10 mg/kg IV Q2W until progression, unacceptable toxicity, or withdrawal. Response was assessed every 6 wks (RECIST 1.1). Best overall response and progression-free survival (PFS) were evaluated. Adverse events (AEs) were graded by NCI CTCAE v4.0. PD-L1 expression was assessed by IHC. Results: As of Oct 23 2015, 151 pts were treated with avelumab (62 pts, 2L; 89 pts, Mn) and followed for median of 49 wks (range 9-84). Treatment-related adverse events (TRAEs) of any grade occurred in 89 pts (58.9%); most common ( > 10%) were infusion-related reaction (19 [12.6%]) and fatigu.
EVALUATION OF DRUG TREATMENT OPTIONS FOR ALZHEIMER'S DISEASE - A REVIEW OF EARLIER STUDIES

Therapeutic treatments for Alzheimer's disease include the cholinesterase inhibitors donepezil, galantamine and rivastigmine. A review of the evidence by searching MEDLINE, Embase, The Cochrane Library and the International Pharmaceutical Abstracts from 1980 through 2007 (July) for placebo-controlled and comparative trials assessing cognition, function, behavior, global change and safety was made. Thirty-three articles on 26 studies were included in the review. Meta-analyses of placebo-controlled data support the drugs modest overall benefits for stabilizing or slowing decline in cognition, function, behavior and clinical global change. Three open-label trials and one double-blind randomized trial directly compared donepezil with galantamine and rivastigmine. Results are conflicting: two studies suggest no differences in efficacy between compared drugs, while one study found donepezil to be more efficacious than galantamine and one study found rivastigmine to be more efficacious than donepezil. Adjusted indirect comparison of placebo-controlled data did not find statistically significant differences among drugs with regard to cognition, but found the relative risk of global response to be better with donepezil and rivastigmine compared with galantamine. Indirect comparisons also favored donepezil over galantamine with regard to behavior, Across trials, the incidence of adverse events was generally lowest for donepezil and highest for rivastigmine. These studies are discussed in this presentation.
Observational Implications of Non-Exponential Discounting

Dans cette note, nous donnons un exemple elementaire avec une fonction d’utilite concave ou la regle d’epargne essentiellement unique et consistante est discontinue ; une telle regle d’epargne ne peut pas survenir avec une fonction d’escompte exponentielle.
Electrical Energy Demand Prediction: A Comparison Between Genetic Programming and Decision Tree

Several recent studies have used various data mining techniques to obtain accurate electrical energy demand forecasts in power supply systems. This paper, for the first time, compares the efficiency of the decision tree (DT) and classic genetic programming (GP) data mining models developed for electrical energy demand forecasting in Nicosia, Northern Cyprus. The models were trained and tested using daily electricity consumptions measured during the period 2011-2016 and were compared in terms of three statistical performance indices including coefficient of determination, mean absolute percentage error and concordance coefficient. The prediction results showed that the proposed models can be effectively applied to forecasts of electrical energy demand. The results also indicated that the GP is slightly superior to DT in terms of the performance indices.
Características de la reputación online y su relación con las tarifas en los hoteles de categoría superior de la ciudad de Mar del Plata

Con la amplia difusion de las herramientas de la web 2.0, el desenvolvimiento del sector hotelero es afectado en forma creciente por las opiniones y valoraciones consignadas en las plataformas de turismo y redes sociales, donde los usuarios recomiendan y advierten a otros, por los servicios recibidos en los hoteles donde se hospedaron. Esta investigacion tiene como proposito caracterizar la reputacion online de los hoteles marplatenses en TripAdvisor, describiendo el perfil de usuario que realiza mayores valoraciones; y la relacion entre el indice de popularidad y la tarifa base doble -habitacion para dos personas adultas-; a fin de ofrecer lineamientos para la definicion de estrategias que permitan mejorar la competitividad del negocio. El estudio se realizo a traves de la captacion y analisis descriptivo-correlacional de los perfiles en TripAdvisor de los hoteles de tres, cuatro y cinco estrellas de la ciudad de Mar del Plata. Los resultados muestran que los hoteles mas valorados son los que poseen categorias mas altas, siendo los perfiles de usuarios que mas participan en TripAdvisor aquellos huespedes que se alojan en la categoria de parejas. Se advierte una relacion leveentre el indice de popularidad y los precios fijados para todas las categorias de hoteles.
Abstract WP160: Inflammatory Markers and Outcomes After Lacunar Stroke: the Levels of Inflammatory Markers in Treatment of Stroke Study

Background: C-reactive protein predicts prognosis after stroke, but relationships of other inflammatory biomarkers to prognosis is uncertain. We hypothesized that concentrations of interleukin 6 (IL6), serum amyloid A, tumor necrosis factor-α receptor 1 (TNFR1), CD40 ligand, and monocyte chemoattractant protein 1 predict recurrent major vascular events (MVE) after lacunar stroke. Methods: Levels of Inflammatory Markers in the Treatment of Stroke (LIMITS) was an international, multicenter, ancillary biomarker study nested within the Secondary Prevention of Small Subcortical Strokes (SPS3) Phase 3 trial in patients with recent lacunar stroke. Patients were randomized to aspirin versus aspirin/clopidogrel. Blood samples were collected at enrollment, and markers measured centrally using ELISA. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals (HR, 95% CI) for risk of MVE (stroke, myocardial infarction, vascular death) after adjusting for demographics, comorbidities, and statin use. Results: Among 1244 lacunar stroke patients (mean age 63.3 ± 10.8 years), there were 115 MVE. Risk increased with concentrations of both TNFR1 (adj HR per standard deviation [SD] 1.21, 95% CI 1.05-1.41) and IL6 (adj HR per SD 1.10, 95% CI 1.02-1.19). Compared with the bottom quartile of TNFR1, those in the top quartile had twice the risk after adjusting for demographics (HR 1.98, 95% CI 1.11-3.52), though this attenuated after adjusting for other risk factors (adjusted HR 1.68, 95% CI 0.93-3.04). There was an interaction between antiplatelet assignment and TNFR1 (p=0.008; figure) and IL6 quartiles (p=0.035); as biomarker concentrations increased, dual antiplatelets became less effective than aspirin alone. Other markers were not associated with prognosis. Conclusions: Among recent lacunar stroke patients, IL6 and TNF receptor concentrations predict risk of recurrent vascular events and efficacy of antiplatelet therapies.
Overtourismus:: Ein Beitrag für eine sozialwissenschaftlich basierte Fundierung und Differenzierung der Diskussion

Ausgehend von einigen sehr stark frequentierten stadtetouristischen Destinationen und befordert durch eine intensive Medienberichterstattung uber Besucherdruck und dadurch ausgeloste negative Effekte erfahrt der Begriff „Overtourism“ und die Diskussion daruber seit 2017 eine hohe offentliche Aufmerksamkeit. Die Diskussion ist dabei vor allem von einigen wenigen stadtetouristischen Destinationen gepragt. Damit sich die Frage, inwieweit die sich an wenigen Extrembeispielen entzundende Diskussion als Hinweis auf eine zunehmende Ablehnung von touristischen Besuchern gesehen werden kann.
Common‐factor stochastic volatility modelling with observable proxy

Multi‐asset modelling is of fundamental importance to financial applications such as risk management and portfolio selection. In this article, we propose a multivariate stochastic volatility modelling framework with a parsimonious and interpretable correlation structure. Building on well‐established evidence of common volatility factors among individual assets, we consider a multivariate diffusion process with a common‐factor structure in the volatility innovations. Upon substituting an observable market proxy for the common volatility factor, we markedly improve the estimation of several model parameters and latent volatilities. The model is applied to a portfolio of several important constituents of the S&P500 in the financial sector, with the VIX index as the common‐factor proxy. We find that the prediction intervals for asset forecasts are comparable to those of more complex dependence models, but that option‐pricing uncertainty can be greatly reduced by adopting a common‐volatility structure. The Canadian Journal of Statistics 48: 36–61; 2020 © 2020 Statistical Society of Canada
Laser damage, a new US standard: What is in it for me?

Successful commerce of science and technology requires standardization of measurement. Today more than ever, there is need for a new Optical Laser Damage standard to increase the efficiency of commerce in the optical industry. The current Laser Damage Standard, ISO 21254, is overly complicated for a general seller/buyer and can produce ambiguous results. To address the challenges to efficient commerce from ISO 21254, OEOSC Task Force 7 (TF7) is developing a new US laser damage standard. The new standard is based on a measurement theory approach and introduced and examined. The optical manufacturer (seller) directly benefits from an operationally effective means to determine acceptance criteria around the ability of categorizing optics that will meet customer’s requirements. OEOSC Task Group TF7 is seeking broad industry support to develop the most useful and robust standard possible. The new US Laser Damage Standard will benefit the optical manufacturing industry and customers alike that use optics susceptible to laser damage in their applications by providing a clear unambiguous pass or fail result. The paper will conclude with a discussion of the path forward in the development of the US laser damage standard.
Aktuelles zu Enthesitis-assoziierter Arthritis und juvenilen Spondyloarthritiden

Zusammenfassung Spondyloarthritiden im Kindesalter zu erkennen, insbesondere früh im Krankheitsverlauf, ist eine besondere Herausforderung für den klinischen Rheumatologen. Die Symptome und Anzeichen bei Erkrankungsbeginn sind im Vergleich zu denen bei Erwachsenen deutlich unterschiedlich, mit häufigerer Arthritis von peripheren Gelenken, Enthesitis und Tarsitis. Juvenile Spondyloarthritiden können neben der archetypischen Enthesitis-assoziierten Arthritis auch in anderen Formen, einschließlich Psoriasis-Arthritis und undifferenzierte Arthritis, auftreten, was eine Abgrenzung schwierig macht. Die Langzeitprognose für Patienten mit juveniler SpA ist variabel und abhängig von den herangezogenen Studien. Diese Inkonsistenz ist wahrscheinlich eine Folge verschiedener Faktoren einschließ-lich der Verwendung unterschiedlicher Klassifikationssysteme, aber auch der untersuchten Bevölkerung. Die Studienlage zu Behandlung und Verlauf der Spondyloarthritiden im Kindesalter ist noch immer sehr dürftig, in den vergangenen Jahren ist vor allem die Datenlage zur Wirksamkeit von TNF-Antagonisten untermauert worden. Langzeitremissionen bei juvenilen Spondyloarthritiden ohne Medikamente sind jedoch weiterhin selten.
An Optimal Choice for QoE with Cooperative Mobile-edge-computing in UDN

MEC and UDN are two key technologies in the field of wireless communication. In a UDN network, deploying MEC servers in both macro and micro base stations can effectively improve user experience. However, according to the actual scenario, the processing capability of each MEC server is different. If the collaborative processing of the server is not considered, some servers may be busy and idle, and how to design a server collaborative processing strategy to get the best user experience is an issue that needs to be addressed. Therefore, we first establish a system model of the topological MEC server under UDN, and then establish the objective function considering delay and energy consumption. In order to find the cooperation strategy between servers, we use cooperation algorithm to find the optimal solution. Finally, the results are compared with the baseline algorithm. The results show that the collaborative strategy can perform better time and energy consumption.
PENGARUH KONTRAK PSIKOLOGIS TERHADAP WORK ENGAGEMENT (STUDI PADA PT. SELECTA KOTA BATU)

Penelitian ini bertujuan untuk mengetahui pentingnya pengaruh kontrak psikologis terhadap work engagement karyawan pada PT Selecta Batu. penelitian ini menggunakan seluruh populasi atas sampel yaitu sebanyak 157 responden, namun hanya 100 responden yang kembali dimana penyebaran kuisioner dilaksanakan di PT. Selecta Batu. Kuesioner yang digunakan adalah Psychological Contract Inventory (PCI) yang dibuat oleh Denise M. Rousseau (2000) dan kuisioner Utrecht Work Engagement Scale (UWES) yang dibuat oleh Scaufelli (2003) yang telah disederhanakan. Karakteristik responden yang diambil adalah karyawan PT Selecta. Analisis variabel yang disebut dilakukan dengan menggunakan alat uji instrumen yaitu uji validitas dan reabilitas, Uji asumsi klasik, Analisis Linier Berganda dan menggunakan Uji Statistik F dan statistik, serta Koefisien Determinasi yang diolah software SPSS 20. Hasil Penelitian ini menunjukkan variabel kontrak psikologis (X) berpengaruh secara signifikan terhadap variabel work engagement (Y). Serta hasil nilai persamaan koefisien determinasi menunjukkan bahwa variabel independen transactional contract, relational contract, dan balanced contract mampu menjelaskan variabel dependend work engagement sebesar 41,7% sedangkan 58,3 % sisanya dijelaskan oleh variabel lain yang tidak diteliti dalam penelitian ini. Kesimpulannya adalah semakin baik kontrak psikologis yang dijalin antara perusahaan dan karyawan, maka work engagement semakin meningkat. Kata Kunci : Kontrak Psikologis, Transactional Contract, Relational Contract, Balanced Contract, Transitional Contract, Work Engagemen