Miracle-dz/UniFAR-FTUs huggingface dataset:
Letter to the Editor - An Ordering Policy for Stock Items when Delivery Can be Expedited

THE ORDERING POLICY IS DEFINED BY A TRIPLE (X,Q,E) WHERE X = INVENTORY LEVEL AT WHICH AN ORDER FOR Q UNITS IS PLACED WITH A DELIVERY LEAD TIME L AND E = EXPEDITING LEVEL. AN EXPRESSION FOR THE TOTAL COST OF SUCH POLICY IS DERIVED BASED ON THE EXPECTED VALUES OF INVENTORY, UNITS SHORT PER UNIT TIME, NUMBER OF ORDERS PER UNIT TIME, NUMBER OF EXPEDITED ORDERS PER UNIT TIME, NUMBER OF UNITS EXPEDITED PER UNIT TIME. UNDER THE ASSUMPTION THAT NO ORDERS ARE OUTSTANDING AT THE TIME AN ORDER IS PLACED, APPROXIMATIONS TO THE OPTIMUM (X, Q, E) ARE DERIVED. /ORMS/
Emerging therapies for adult soft tissue sarcoma

Soft tissue sarcoma (STS) are a broad group of rare tumors. Cornerstone of treatment is surgery. Complementary radiotherapy is recommended in high-risk STS arising from extremities. Doxorubicine ± ifosfamide based cytotoxic chemotherapy, explored in few randomized trials, showed a certain degree of activity, playing an established role only in unresectable disease. Since peculiar chemosensitivity towards alternative drugs was described for different metastatic subtypes in second or further lines, the modern concept of ‘histology-driven chemotherapy’ has been accepted and employed: gemicitabine ± dacarbazine, trabectedin and taxanes used respectively in patients with leiomyosarcoma, solitary fibrous tumor, myxoid/round cell liposarcoma, angiosarcoma. Recent discoveries about molecular pathways involved in STS tumorogenesis led to develop molecular targeted agents such as imatinib used in advanced dermatofibrosarcoma protuberans (DFSP) or metastatic DFSP-related fibrosarcoma, pazopanib, approved as second line regimen in advanced non-adipocitic STS and recently sunitinib in solitary fibrous tumors, alveolar soft part sarcoma and extraskeletal myxoid chondrosarcoma.
Wideband Monopole Antenna With Less Nonground Portion For Octa-Band WWAN/LTE Mobile Phones

An octa-band WWAN/LTE monopole antenna with a size of 80 mm × 8 mm × 5.8 mm for 5.7-inch mobile phones is proposed and studied. The proposed antenna consists of a folded metal plate with a lumped-element high-pass matching circuit. The working mechanism is analyzed based on the S-parameters and the surface current distributions. The 0.25-wavelength, 0.5-wavelength, and 1-wavelength modes of the monopole antenna are excited and used. The attractive merit of the proposed antenna is that the height of the nonground portion is only 8 mm. A prototype is fabricated and measured. Its measured -6 dB impedance bandwidths are 290 MHz (0.69-0.98 GHz) and 1.11 GHz (1.63-2.74 GHz) which cover the LTE700, GSM850, GSM900, GSM1800, GSM1900, UMTS, LTE2300, and LTE2500 bands. Within the two frequency bands, good radiation performances are obtained.
Remarkable infidelity of polymerase γA associated with mutations in POLG1 exonuclease domain

Objective: To better understand the still unknown pathologic mechanism involved in the accumulation of multiple mtDNA deletions in stable tissues. Methods: A large-scale screening of mtDNA molecules from skeletal muscle was performed in 14 patients with progressive external ophthalmoplegia (PEO) and 2 patients with mitochondrial neurogastrointestinal encephalomyopathy carrying mutations on ANT1, C10ORF2 or POLG1, and TP genes. Results: Patients with at least one mutation in the exonuclease domain of POLG1 showed the highest frequency of individually rare point mutations only in the mtDNA control region; in addition, high levels, in terms of frequency and heteroplasmy, of recurrent mutations (A189G, T408A, and T414G) and alterations affecting the (HT)D310 region were detectable in many of the patients. Two homozygous POLG1 mutations, within the exonuclease domain, were able to induce an increased mutational burden also in fibroblasts from patients with PEO. Conclusions: Specific POLG1 mutations directly affect the integrity of the mtDNA by reducing its proof-reading exonuclease activity, resulting in the accumulation of heteroplasmic levels of both randomly rare and recurrent point mutations in the skeletal muscle tissue and fibroblasts.
An Approach for Prioritizing NFRs According to Their Relationship with FRs

Due to the budgetary deadlines and time to market constraints, it is essential to prioritize software requirements. The outcome of requirements prioritization is an ordering of requirements which need to be considered first during the software development process. To achieve a high quality software system, non-functional requirements (NFRs) must be taken into consideration throughout the prioritization process. Although several requirements prioritization methods have been proposed so far, the research on prioritizing non-functional requirements is limited. In this paper, we propose a quantitative approach based on Fuzzy Logic and Alpha cut approach which aims to perform the process of prioritizing non-functional requirements. Application of the proposed approach provides the practitioners with a prioritized list of non-functional requirements which are prioritized based on their relationship with functional requirements (FRs).
Effectiveness and Transparency of Sentiment Analysis Tools for Academic Purposes

This work explains the importance of using sentiment analysis tools for proceeding research in different spheres of studying and knowledge mining. Here the definition of sentiment analysis is given, as well as different cases of its usage for texts processing. A comparison of effectiveness, ease of use and computing time for two open-source tools is included in this paper. This helps in making conclusions about the degree of tools’ development and their possible future opportunities in a research process. Readers of this work are supposed to find out, which advantages and disadvantages do the tools have, while examining their main characteristics.
Topology identification of two-layer unidirectional complex dynamical networks based on auxiliary system approach

This paper investigates topology identification of two-layer unidirectional complex dynamical networks based on auxiliary-system approach. Particularly, consider the interested layer as response layer, the other layer as drive layer, then construct a auxiliary layer which is driven by the driving signal as an identical duplication of the response layer. Based on the theory of Barbalat's lemma, some control inputs and updating laws are designed so that nodes in the auxiliary layer reaches complete synchronization with their counterparts in the response layer and the unknown topology of the response layer can be adaptively identified, meanwhile, the drive layer and the response layer achieve generalized synchronization. Numerical simulations are provided to illustrate the effectiveness of the proposed method. We expect that the analysis in this paper could prompt attention and provide basic insight into further research on detecting the route and the source of rumor and pseudo news spreading.
Lyme Borreliosis in Canada: Biological Diversity and Diagnostic Complexity from an Entomological Perspective

Abstract Lyme borreliosis (LB), also known as Lyme disease, is emerging as a serious tick-borne illness across Canada. More than three decades of research on LB in North America and Europe have provided a large, complex body of research involving well-documented difficulties at several levels. However, entomologists are well situated to contribute to resolving some of these challenges. The central pathogen in LB, the spirochete Borrelia burgdorferi Johnson et al., includes numerous genospecies and strains that are associated with different disease symptoms and distributions. The primary vectors of LB are ticks of various Ixodes Latreille species (Acari: Ixodida: Ixodidae), but questions linger concerning the status of a number of other arthropods that may be infected with B. burgdorferi but do not transmit it biologically. A variety of vertebrates may serve as reservoirs for LB, but differences in their ability to transmit LB are not well understood at the community level. Persistent cystic forms of and immune-system evasion by B. burgdorferi contribute to extraordinary challenges in diagnosing LB. Multiple trade-offs constrain the effectiveness of assays like ELISA, Western blot, polymerase chain reaction, and microscopic visualization of the spirochetes. Consequently, opportunities abound for entomologists to contribute to documenting the diversity of the players and their interactions in this devilishly complex disease.
Targeting of two signal transduction pathways to different regions of the bacterial cell

Components of bacterial chemosensory pathways which sense via transmembrane receptors have been shown to localize to the cell poles. Many species, however, have operons encoding multiple putative chemosensory pathways, some including putative cytoplasmic receptors. In‐genome fusions to single or multiple genes encoding components of two chemosensory pathways in Rhodobacter sphaeroides, cheOp2 and cheOp3, revealed that while sensory transducing proteins associated with transmembrane receptors and encoded on cheOp2 were targeted to the cell poles, the proteins associated with putative cytoplasmic receptors and encoded on cheOp3 were all targeted to a cytoplasmic cluster. No proteins were localized to both sites. These data show that bacteria target components of related pathways to different sites in the cell, presumably preventing direct cross‐talk between the different pathways, but allowing a balanced response between extracellular and cytoplasmic signals. It also indicates that there is intracellular organization in bacterial cells, with specific proteins targeted and localized to cytoplasmic regions.
Distribution of Quantiles in Samples from a Bivariate Population

Let F (x,y) be t he joint d istri but ion function of (X, y), possessing a probability density funct ion f(x,y). Let F I(X) and l>'2(Y) be the marginal distribut ion fun ctions of X and Y respectively. Let a be a quantile of FI (x) and f3 be a quantile of F2(y). A random sampl e (X k, Y k), k= 1, 2, . , n, is drawn a nd t he values on each variate are ordered so that X:< X; a nd Y;< Y; if i < j. Let i and j be the greatest integers such t hat i /n::;' FI (a) and j /n::;' F2(f3), a nd let NI be the number of elements (X, Y) such t hat X<X; am! Y < Y. The joint distributio n of (M ,X;, Y;) is obtained and is shown to I'e asymptot icall y ;lOrlllal. Estimates a nd co nfidence limits on t he parameters of interest are also given.
Cervical Intraepithelial Neoplasia 2, 3 in Pregnancy: Time to Consider Loop Cone Excision in the First Trimester of Pregnancy?

Objectives To report the outcome of patients diagnosed with cervical intraepithelial neoplasia 2, 3 (CIN 2, 3) during pregnancy, who were treated by large loop excision of the transformation zone (LLETZ) in the first trimester or were followed up conservatively and treated after delivery. Methods Patients diagnosed with CIN 2, 3 during pregnancy who were treated with LLETZ or were conservatively followed up were included. Complications of the LLETZ, pathologic results, and pregnancy outcome of both groups were examined after delivery. Results Thirty-one patients were included in the study. Eighteen were conservatively followed up and 13 underwent LLETZ during the first 14 weeks of pregnancy. Four patients (12.9%) in the study group were diagnosed with invasive cervical cancer. From women who underwent LLETZ, 9 patients continued their pregnancy, 7 of which had term normal deliveries and 2 had late preterm deliveries. No complications of severe bleeding or miscarriage were reported in any of the treated patients. Conclusions Large loop excision of the transformation zone procedure in the first trimester of pregnancy is a safe procedure, with the advantage of treating definitively CIN 2, 3 lesions and preventing the devastating consequences of undiagnosed cervical cancer. We suggest that LLETZ should be performed more liberally in the first trimester of pregnancy.
The impact of training sequence and between-category similarity on unsupervised induction

Studies of supervised categorization often show better learning when examples are presented in random alternation rather than massed by category, but such interleaving impairs learning in unsupervised tasks. The exemplar comparison hypothesis explains this result by assuming that people in unsupervised tasks discover generalizations about categories by comparing individual examples, and that interleaving increases the difficulty of such within-category comparisons. The category invention hypothesis explains the interleaving effect by assuming that people are more likely to merge or aggregate potentially separable categories when they are interleaved, and this initial failure to recognize separate categories then acts as an effective barrier to further learning. The present experiments show that the interleaving effect depends on the similarity or alignability of the presented categories. This result provides evidence in favour of the category invention hypothesis, which expects that highly dissimilar (nonalignable) categories will resist aggregation and hence will not be affected by interleaving. The nonmonotonic pattern of learning, and the interaction between sequence and similarity, observed in the alignable conditions of Experiment 3 were also consistent with category invention, but not with exemplar comparison. Implications are discussed for real-world learning, especially the relationship between exposure and learning and between supervised and unsupervised learning.
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex

The multifunctional actions of transforming growth factor beta 1 (TGF-beta 1) indicate that it has a pivotal control function in many physiological and pathological processes. An important property of TGF-beta 1 is its ability to activate its own mRNA expression and thereby increase its own secretion. Two distinct regions of the promoter of the TGF-beta 1 gene are responsive to autoregulation: one 5' to the upstream transcriptional start site and another located between the two major start sites. In both promoter regions, autoinduction is mediated by binding of the AP-1 (Jun-Fos) complex. An important contribution to this positive regulation is the autoactivation of c-jun transcription by AP-1. Cotransfection of antisense c-jun or antisense c-fos expression vectors prevents TGF-beta 1 autoinduction. These results demonstrate that both components of the AP-1 complex are required for TGF-beta 1 autoinduction. Induction of jun expression by TGF-beta 1, as well as jun autoinduction, may amplify the action of TGF-beta 1 during normal development and oncogenesis.
Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease

Traditionally, Crohn’s disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory Th17 cells, a novel T cell population characterised by the master transcription factor RORγt, the surface markers IL23R and CCR6, and by production of the proinflammatory cytokines IL17A, IL17F, IL21, IL22 and IL26, and the chemokine CCL20. Th17 cells differentiate under the influence of IL1β, IL6, IL21 and IL23. Recent studies indicate that TGFβ is essential not only for the development of murine Th17 cells but also for differentiation of human Th17 cells. TGFβ reciprocally regulates the differentiation of inflammatory Th17 cells and suppressive Treg subsets, with the concomitant presence of proinflammatory cytokines favouring Th17 cell differentiation. Several studies demonstrated an important role of Th17 cells in intestinal inflammation, particularly in Crohn’s disease. Genome-wide association studies indicate that IL23R and five additional genes involved in Th17 differentiation (IL12B, JAK2, STAT3, CCR6 and TNFSF15) are associated with susceptibility to Crohn’s disease and partly also to ulcerative colitis. Taken together, both Th1 and Th17 cells are important mediators of inflammation in Crohn’s disease, although activities previously ascribed to IL12 may be mediated by IL23. Anti-IL12/IL23p40 antibody therapy, which targets both Th1 and Th17 cells, is effective in Crohn’s disease. However, the complex relationship between Th1 and Th17 cells has not been completely analysed. This will be of great importance to delineate the specific contributions of these cells to Crohn’s disease and other autoimmune diseases.
Running Head : EXECUTIVE FUNCTIONING AND MOTOR DIFFICULTIES Executive functioning , motor difficulties and Developmental Coordination Disorder

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Creating authentic simulated patient roles: working with volunteers

Context and setting The use of simulated patients (SPs) in medical education is widespread and increasing. These ‘patients’ are valued for many reasons, including their ability to bring patient perspectives to the forefront of student learning. Although SPs bring their own expertise to the encounter, their value is in part dependent on the patient roles they are asked to play. We wanted to generate new SP roles quickly and efficiently and ensure a real patient perspective was offered. Why the idea was necessary Writing roles for SPs can be time-consuming. Although we use a range of approaches, real patients are rarely included in the process. Roles are usually constructed by faculty staff (clinicians and educators) and do not necessarily represent the views of real patients. There are many published examples of discrepancies between clinician and patient experiences of health care. Unless real patients are involved in the process, we are not really in a position to claim authenticity. What was done We invited volunteers from our local community to complete a template for SP roles. Volunteers were asked to respond in relation to the last time they went to a general practitioner and to frame their answers in relation to what they were experiencing at that time. That is, they were asked to give, from their perspective: reason(s) for the consultation; ideas about what was wrong; what they were most concerned about; what they thought the doctor could do; their medical and social history, and their attitude towards the health care service and how they might respond to specific clinician behaviours. All information was anonymised. Evaluation of results and impact A total of 21 roles were produced by 15 female and six male volunteers, aged 17–90 years (mean age = 37.5 years) within 1 week, which quickly expanded our bank. Volunteers recorded a range of acute (e.g. rash, painful swollen knee, sore throat), chronic (e.g. insomnia, lumps, tiredness), multiple pathologies and health-seeking behaviours (e.g. loss of weight, fitness, smoking cessation). We do not know if the information submitted by volunteers is authentic. However, after reviewing roles we became aware of our limitations as faculty in constructing such diverse roles. This was manifested by the volunteers’ use of language to describe their symptoms, their understanding of medical concepts, the names they used for drugs, their priorities in presenting information to the clinician and their expectations of treatment. As faculty, it is challenging to construct roles from the perspectives of a new migrant Ethiopian teenager with little confidence in her spoken English, or a 48-year-old man whose only means of mobility is a wheelchair. Where lay people are willing and able to contribute to medical education by sharing their personal experiences, we should seek ways to tap this input. We easily met our initial goal and the experience has challenged us to think critically and creatively about other ways of including real patients in the development of educational materials, although we recognise there are limitations.
Pseudo 3D image generation with simple depth models

A procedure for creating 3D images from existing 2D images is proposed. The proposed method is developed to fulfill the growing need for high quality generic 3D contents. The proposed method is intended to construct approximate structures to give 3D images without an explicit sense of incongruity. The depth data is generated with simple models and by warm/cool color theory. The proposed method has advantages over conventional methods in picture quality, low numerical complexity, and no need of tuning of parameters for different types of pictures. And the method can be applied for any visual devices which output or display pseudo 3D images, and pseudo 3D content creation.
Effect of a spiritual care program on levels of anxiety in patients with leukemia

Background: Leukemia is the most common and fatal cancer among young adults. Among all malignancies, it has the greatest effects on emotional and mental aspects of the patients. While 25-33% of patients with non-hematological malignancies suffer from anxiety disorder, some studies have reported the rate among patients with leukemia as high as 50%. Anxiety can negatively affect other important characteristics and parameters in patients with cancer. Furthermore, cancer increases the patients’ spiritual needs. Therefore, spirituality has a significant role in adapting to leukemia and coping with its consequent mental disorders such as anxiety. This study was hence performed to determine the effects of a spiritual care program on anxiety of patients with leukemia. Materials and Methods: This randomized clinical trial was conducted in Sayyed-Al-Shohada Hospital affiliated to Isfahan University of Medical Sciences (Isfahan, Iran) in 2012. Sixty four adult patients with leukemia were randomly divided into the experiment and control groups. The spiritual care program including supportive presence and support for religious rituals was implemented for 3 days. Anxiety subscale from the 42-item depression, anxiety and stress scale was completed before and after the intervention for both groups. Data was analyzed using descriptive and inferential statistical methods (Chi-square, paired and independent t-tests) in SPSS18. Results: There was no significant difference between the two groups before the intervention. However, after the intervention, mean score of anxiety were significantly lower in the experiment group than in the control group (P < 0.01). There was also a significant difference in the scores of the experiment group before and after the intervention (P < 0.01). Such a difference was absent in the control group. Conclusions: Our spiritual care program could successfully decrease anxiety levels in patients with leukemia. Therefore, in cases of refractory diseases such as cancer, nurses have to apply a holistic care approach with emphasis on spiritual care.