Miracle-dz/UniFAR-FTUs huggingface dataset:
A Genetic Programming based Algorithm for Predicting Exchanges in Electronic Trade using Social Networks’ Data

Purpose of this paper is to use Facebook dataset for predicting Exchanges in Electronic business. For this purpose, first a dataset is collected from Facebook users and this dataset is divided into two training and test datasets. First, an advertisement post is sent for training data users and feedback from each user is recorded. Then, a learning machine is designed and trained based on these feedbacks and users' profiles. In order to design this learning machine, genetic programming is used. Next, test dataset is used to test the learning machine. The efficiency of the proposed method is evaluated in terms of Precision, Accuracy, Recall and F-Measure. Experiment results showed that the proposed method outperforms basic algorithm (based on J48) and random selection method in selecting objective users for sending advertisements. The proposed method has obtained Accuracy=74% and 73% earning ration in classifying users.
Hemostatic properties of normal and perturbed vascular cells

Vascular endothelial and smooth muscle cells actively maintain vessel wall thromboresistance by expressing several antithrombotic properties. With perturbation or injury, vascular cells express thrombogenic properties. Loss of vessel wall thromboresistance may be associated with thrombosis and vascular disease. — Rodgers, G. M. Hemostatic properties of normal and perturbed vascular cells. FASEB J, 2: 116‐123; 1988.
Carbon monoxide in biology and medicine

Carbon monoxide (CO), a product of organic oxidation processes, arises in vivo during cellular metabolism, most notably heme degradation. CO binds to the heme iron of most hemoproteins. Tissue hypoxia following hemoglobin saturation represents a principle cause of CO‐induced mortality in higher organisms, though cellular targets cannot be excluded. Despite extreme toxicity at high concentrations, low concentrations of CO can confer cytoprotection during ischemia/reperfusion or inflammation‐induced tissue injury. Likewise, heme oxygenase, an enzyme that produces CO, biliverdin and iron, as well as a secondary increase in ferritin synthesis, from the oxidation of heme, can confer protection in vivo and in vitro. CO has been shown to affect several intracellular signaling pathways, including guanylate cyclase, which generates guanosine 3′:5′ cyclic monophosphate and the mitogen‐activated protein kinases (MAPK). Such pathways mediate, in part, the known vasoregulatory, anti‐inflammatory, anti‐apoptotic and anti‐proliferative effects of this gas. Exogenous CO delivered at low concentrations is showing therapeutic potential as an anti‐inflammatory agent and as such can modulate numerous pathophysiological states. This review will delve into the biological significance and medical applications of this gas molecule. BioEssays 26:270–280, 2004. © 2004 Wiley Periodicals, Inc.
Decreased bone density in inflammatory bowel disease is related to corticosteroid use and not disease diagnosis

Although corticosteroid therapy is associated with the development of osteopenia, it is unclear whether the cause of osteopenia in inflammatory bowel disease (Crohn's disease and ulcerative colitis) is related to corticosteroid therapy or other disease‐related variables. Patients with Crohn's disease (a diffuse gastrointestinal disease) could have greater osteopenia than patients with ulcerative colitis because of small bowel disease and secondary malabsorption of calcium and vitamin D. A cross‐sectional analysis of consecutive patients with Crohn's disease and ulcerative colitis was undertaken. Bone density was determined by measurements of the L2–L4 spine, the total hip, and Ward's triangle using dual energy X‐ray absorptiometry (DXA). A number of clinical parameters were recorded prior to bone density evaluation and analyzed by univariate and subsequently multivariate analysis to determine possible predictors of osteopenia. Of the 26 patients with Crohn's disease, diminished bone density (a Z score of at least −1) was found at the hip in 64% and at the spine in 44%; and of the 23 patients with ulcerative colitis diminished bone density was found at the hip in 43% and at the spine in 48%. Among all the variables tested, only corticosteroid use was a statistically significant predictor of diminished bone density (p = 0.025 for the spine and hip and p = 0.005 for Ward's triangle). Disease diagnosis (Crohn's disease compared with ulcerative colitis) did not predict or correlate with diminished bone density. No obvious associations were seen between the measurements of any serum hormones or biochemistries and bone density, although the patients using corticosteroids had lower serum calcium levels than the nonusers. Separate multivariate analyses were performed for males and females. Corticosteroid use was statistically significantly associated with diminished bone density in females but not in males. All patients with inflammatory bowel disease (both Crohn's disease and ulcerative colitis), independent of whether or not they have small bowel disease, who have been using corticosteroids for long periods should have their bone density status investigated, since they have a high prevalence of diminished bone density and, therefore, are at risk for bone fractures. Further studies are required to sort out factors that may make bone density in females more sensitive to the effects of corticosteroids than that of males.
CD34+CD90+ Cells and Late Hematopoietic Reconstitution after Autologous Peripheral Blood Stem Cell Transplantation

Autologous peripheral blood stem cell transplantation (PBSCT) has been demonstrated to result in rapid, stable long-term engraftment. However, there has been considerable debate concerning the cells responsible for early and late hematopoietic reconstitution after PBSCT. Recently, CD34+ hematopoietic stem and progenitor cells have been clearly divided into two subpopulations by flow cytometry; namely undifferentiated pluripotent stem cells and differentiated committed progenitor cells. However, only a few studies have defined which subset contained in graft products might be the most predictive for late hematopoietic reconstitution after PBSCT. In this review, we present updated information regarding the relationships between the number of infused CD34+ cells or their immature subsets such as CD34+CD90+ cells and the late hematopoietic reconstitution after PBSCT, and discuss the threshold dose of CD34+CD90+ cells required for sustained long-term engraftment.
Synergistic promotion of gibberellin and cytokinin on direct regeneration of floral buds from in vitro cultures of sepal segments in sinningia speciosa hiern

SummaryThis study reports the direct regeneration of flower buds from cultured sepal segments of Sinningia speciosa Hiern. Two types of floral bud regeneration were observed: regeneration of floral buds only (designed as BF) and regeneration of both floral and vegetative buds (designed as BF+V). The capacity of BF regeneration was closely related to the location of sepal segments and the concentration of exogenous gibberellin (GA3) and cytokinin in the medium. On the medium containing 1.0mgl−1 GA3, the addition of 6-benzyladenine (BA) significantly increased the frequency of total flower bud (BF+BF+V) formation, with the frequency up to 91.5% in the presence of 0.4mgl−1 BA. On the medium containing 0.1mgl−1 BA, the addition of GA3 also increased the frequency of total flower bud regeneration, with the frequency up to 74.3% in the presence of 1.0mgl−1 GA3, but no further increase in regeneration was observed when the GA3 concentration was higher than 1.0mgl−1. The capacity of BF regeneration from different locations of sepal segments was differential. The adaxial part of sepal segments gave rise to the highest frequency of 56.7 and 84.3% for BF and BF+BF+V, respectively.
Does taping in addition to physiotherapy improve the outcomes in subacromial impingement syndrome? A systematic review

ABSTRACT Background: Taping is used with or without other interventions for many purposes, especially to manage pain and improve functional activity in patients with shoulder pain. Objectives: The aim of this review was to determine whether any taping technique in addition to physiotherapy care is more effective than physiotherapy care alone in patients with shoulder impingement syndrome. Methods: A systematic search of Cochrane Database of Systematic Review, MEDLINE (EBSCO), Physiotherapy Evidence Database (PEDro), CINAHL (EBSCO), PUBMED, AMED, EMBASE (OVID), The Kinesio Kinesio® Taping Method, Kinesio® Tex Tape UK and International websites (www.kinesiotaping.co.uk; www.kinesiotaping.com) was conducted to June 2015. The outcome measures were pain, disability, range of motion and muscle strength. As data were not suitable for meta-analysis, narrative synthesis were applied. Results: Three randomized controlled trials and one controlled trial (135 patients) were included. The results were conflicting and weak on the effectiveness of taping as an adjunct therapy for improvement of pain, disability, range of motion and muscle strength. Conclusion: Clinical taping in addition to physiotherapy interventions (e.g. exercise, electrotherapy, and manual therapy) might be an optional modality for managing patients with shoulder impingement syndrome, especially for the initial stage of the treatment; however, we need further robust, placebo controlled and consistent studies to prove whether it is more effective than physiotherapy interventions without taping.
Functional assessment of TSC1 missense variants identified in individuals with tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the TSC1 or TSC2 genes. The TSC1 and TSC2 gene products, TSC1 and TSC2, form a complex that inhibits the mammalian target of rapamycin (mTOR) complex 1 (TORC1). Previously, we demonstrated that pathogenic amino acid substitutions in the N‐terminal domain of TSC1 (amino acids 50–224) are destabilizing. Here we investigate an additional 21 unclassified TSC1 variants. Our functional assessment identified four substitutions (p.L61R, p.G132D, p.F158S, and p.R204P) between amino acids 50 and 224 that reduced TSC1 stability and prevented the TSC1‐TSC2‐dependent inhibition of TORC1. In four cases (20%), our functional assessment did not agree with the predictions of the SIFT amino acid substitution analysis software. Our new data confirm our previous finding that the N‐terminal region of TSC1 is essential for TSC1 function. Hum Mutat 33:476–479, 2012. © 2011 Wiley Periodicals, Inc.
Selective in vitro response of thymus-derived lymphocytes from Treponema pallidum-infected rabbits

The blastogenic response of nylon wool-separated peripheral-blood lymphocytes from Treponema pallidum-infected rabbits was tested in vitro with mitogens and T. pallidum antigens. The mitogenic response of the enriched T-cell population to concanavalin A and phytohemagglutinin was depressed during the first 3 to 4 weeks of infection, similar to the pattern observed with unfractionated cells. Shortly thereafter, levels of blastogenesis returned to values of uninfected cultures. Enhanced blast transformation was seen immediately when purified T-cells from infected rabbits were exposed in vitro to T. pallidum antigens. Although these relatively high levels of blastogenesis were maintained for the duration of the experiment, cultures of unfractionated lymphocytes from infected rabbits did not exhibit an increased blastogenic response to the same antigen preparation until 3 to 4 weeks after infection. Autologous serum from infected rabbits decreased the lymphocyte response to T. pallidum antigen. The stimulatory effects of anti-immunoglobulin G and lipopolysaccharide on nylon wool-fractionated or unfractionated lymphocytes from both infected and control rabbits were similar throughout the course of infection. During the first 6 weeks of experimental disease, there was a 25 to 31% increase in the number of lymphocytes circulating in the peripheral blood of T. pallidum-infected rabbits.
Receptor Binding Domain of Escherichia coli F18 Fimbrial Adhesin FedF Can Be both Efficiently Secreted and Surface Displayed in a Functional Form in Lactococcus lactis

ABSTRACT Adherence of F18 fimbrial Escherichia coli to porcine intestinal epithelial cells is mediated by the adhesin (FedF) of F18 fimbriae. In a previous study, we demonstrated the specificity of the amino acid residues between 60 and 109 as the receptor binding domain of FedF. In this study, different expression, secretion, and anchoring systems for the receptor binding domain of the FedF adhesin in Lactococcus lactis were evaluated. Two partially overlapping receptor binding domains (42 and 62 amino acid residues) were expressed as fusions with L. lactis subsp. cremoris protein PrtP for evaluation of secretion efficiency. To evaluate the cell surface display of these FedF-PrtP fusions, they were further combined with different lengths of PrtP spacers fused with either the L. lactis AcmA anchor or the PrtP cell wall binding domain. An HtrA-defective L. lactis NZ9000 mutant was constructed to determine its effect on the level of secreted or anchored fusion proteins. Recombinant L. lactis clones secreting the receptor binding domain of F18 fimbriae as a fusion with the H domains of L. lactis protein PrtP were first constructed by using two different signal peptides. FedF-PrtP fusions, directed by the signal sequence of L. brevis SlpA, were throughout found to be secreted at significantly higher quantities than corresponding fusions with the signal peptide of L. lactis Usp45. In the surface display systems tested, the L. lactis AcmA anchor performed significantly better, particularly in the L. lactis NZ9000ΔhtrA strain, compared to the L. lactis PrtP anchor region. Of the cell surface display constructs with the AcmA anchor, only those with the longest PrtP spacer regions resulted in efficient binding of recombinant L. lactis cells to porcine intestinal epithelial cells. These results confirmed that it is possible to efficiently produce the receptor binding domain of the F18 adhesin in a functionally active form in L. lactis.
Driving a Stake Into Resurgent TB

Eighty years after the first tuberculosis vaccine was developed from a bovine cousin of Mycobacterium tuberculosis , the bacterium that causes the disease, its efficacy has come into question. Health leaders have been saying they need a new vaccine; now a fascinating conjunction of events has led to trials of at least five new TB vaccines. But who will pay for them?
Application of Adaptive Finite Element Method for Elliptic Partial Differential Equations to the Laplace Beltrami Operator on Graphs

The Laplace Beltrami operator, known as an elliptic operato r for functions defined on surfaces, appears in some applications in sciences a d engineerings. In this paper we consider the Laplace Beltrami operator ∆Γ on surfacesΓ defined as graphs of C2 functions on a flat domainΩ ⊂ Rd−1 (d ≥ 2), ∆Γu= f on Γ, u= 0 on ∂Γ. Based on some properties of differential geometry, we trans formed the Laplace Beltrami operator on the surface Γ to get an elliptic operator on the flat domain Ω, −div(A(∇u)T) = F in Ω, u= 0 on ∂Ω. We applied an adaptive finite element method (AFEM) for a gene ral second order linear elliptic partial differential equations developed by K. Me kchay and R. H. Nochetto to solve the transformed problem. The a posteriori error estimates i n nergy norm and the design or algorithm are derived accordingly for the transformed prob lem in the sense of the elliptic operator. The discretization and mesh generations of the AF EM algorithm rely on indicators and oscillations which now depend on the data A ndF of the elliptic operator onΩ and do not involve the geometric property of the surface Γ. A numerical experiment for the AFEM algorithm is provided to illustrate the theoretical result . 2010 Mathematics Subject Classification: 65N12, 65N15, 65N 30, 65N50, 65Y20
Surgical Management of Mandibular Ameloblastoma and Immediate Reconstruction with Nonvascularized Bone Graft and Hyperbaric Oxygen Therapy

Extensive resection of tumor often results in bone and soft tissue defects that cause functional and esthetic consequences. The reconstructive surgery is extremely important for the rehabilitation of these patients. The purpose of this study is to report on the use of Hyperbaric Oxygen therapy (HBO) in the case of a large ameloblastoma treated with segmental resection and reconstructed immediately with nonvascularized bone graft (NVBGs) from iliac crest. A 41-year-old woman was referred to our department because of paresthesia of the inferior alveolar nerve and history of swelling in the molar and ramus region of the left mandible. Panoramic radiograph depicting well-defined multilocular radiolucency extending from second premolar region to the left ramus region. An incisional biopsy confirms the diagnosis of solid ameloblastoma. The treatment of choice was segmental mandibular resection and immediate mandibular reconstruction using NVBGs from iliac crest, followed by removal of internal fixation and placement of dental implants with immediate loading. The patient received preoperative HBO (a 90-min session at 2.2-2.4 atmospheres, five times per week for two weeks, for a total of up to 10 sessions). Postoperative HBO (10 further 90-min sessions) was administered within 2 weeks. The patient received rehabilitation with a mandibular implant-supported fixed complete dental prosthesis. The present study showed successful management of mandibular ameloblastoma that associated extensive surgery, immediate reconstruction with NVBGs from iliac crest, hyperbaric oxygen therapy and dental implants. These combined procedures allowed removal of lesion and reestablishment of mandibular contour
Energy Efficient Clustering Algorithm for Wireless Sensor Networks using Fuzzy Logic

The network lifetime is an important issue for employing wireless sensor networks in space and extreme environments. This is due to the fact that the sensing node energy is mainly consumed by transmissions. For maximizing the network lifetime in this paper a multi-hop clustering algorithm using the fuzzy logic improvement methods is introduced. The cluster heads nodes selection is based on four descriptors; residual energy as primary parameter, node proximity to its neighbors (centrality), distance to base station and node concentration. The proposed multi-hop communication in cluster nodes and between cluster heads reduces the consumption of energy in the network. The results of proposed algorithm are compared with LEACH, TLCP and EHEED algorithms in MATLAB environment. The three metrics FND (first node die), HND (half node die) and LNA (last node alive) show the efficiency of proposed algorithm for the network lifetime.
Towards Measurement of Interaction Quality in Social Robotic Telepresence

This paper presents tools for measuring the quality of interaction in social mobile robotic telepresence. The methodology is in part based on Adam Kendon’s theory of Fformations. The theory is based on observations of how bodies naturally orient themselves during interaction between people in real life settings. In addition, two presence questionnaires (Temple Presence Inventory and Networked Minds Social Presence Inventory), designed to measure the users’ perceptions of others and the environment when experienced through a communication medium were used. The perceived presence and ease of use are correlated to the spatial formations between the robot and an actor. Use of the tools is validated experimentally on a dataset consisting of interactions between an elder (actor) and 21 different users being trained in piloting a mobile robotic telepresence unit. The evaluation has shown that these tools are suitable for evaluating mobile robotic telepresence and also that correlations between the tools used exist. Further, also from a local user perspective, the spatial formations have affected the perceived comfort in an interaction.
Exemplar-SVMs for Action Recognition

This goal of this paper is to introduce a method for action recognition that significantly reduces the labeling process. The method involves training a separate linear support vector machine (SVM) classifier for each selected exemplar and combining the scores to form mid-level features. Our approach is trained and tested on the UCF Sports Action data set. The accuracies achieved by the combined Exemplar-SVMs method approaches the best reported accuracies on the UCF Sports Action data set using a reduced amount of labeled data.
A Combinatorial Proof of a Family of Multinomial-Fibonacci Identities

In this paper we generalize completely a class of multinomial-Fibonacci identities. They are given in a variety of forms, including one associated with the Zeckendorf representation of an integer as the sum of non-consecutive Fibonacci numbers, which may be regarded as the canonical form for these identities. Our proofs are obtained via both combinatorial and algebraic methods.
OBOPedia: An Encyclopaedia of Biology Using OBO Ontologies

Ontologies contain knowledge about a domain for use by tools or humans. A source of knowledge should be usable by a human to ‘find out about’ or learn about the entities of a domain and their relationship to each other. The corpus of biomedical ontologies now contains ‘encyclopaedic’ knowledge about biology and should be capable of being used by humans to learn about entities in molecular biology. Yet multiple separate ontologies and the typical style of presentation of the knowledge in the ontologies mean that their use as a learning resource is sub-optimal. To address this issue we have created OBOPedia, a web based encyclopaedia of biology as seen by the Open Biomedical Ontologies (OBO) Consortium. OBOPedia exploits the OBO’s use of standard representations and meaningful human readable terms and natural language definitions to create a basic OBOPedia encyclopaedia entry. An entry is supplemented with an ontology’s synonyms and uses the ontology’s taxonomic links to provide ‘see also’ cross-references within the alphabetical list of entries. Currently, OBOPedia has access to ten OBO ontologies, including all the OBO Foundry ontologies, which have a total of over 210,000 entries. Our evaluations indicate that an OBOPedia style of presentation has a role as an alternative way of presenting knowledge of a domain collected as an ontology or ontologies. OBOPedia offers another view into a field of interest that is based on a collection of ontologies as a reference resource, but one in which a user need not know it is an ontology. OBOPedia may be used via http://www.obopedia. org.uk. The source code and documentation for OBOPedia are available via https://bitbucket. org/adam944/ontologyencyclopaedia.
Visualization of Stimulation Patterns in Cochlear Implants: Application to Event-Related Potentials (P300) in Cochlear Implant Users

Auditory P300 potentials obtained in cochlear implant users were evoked with tone bursts designed to reflect the frequency stimulation patterns of intracochlear electrodes. To visualize these stimulation patterns in MED-EL COMBI 40+ cochlear implants, we calculated color-coded plots of the charge of each stimulus pulse as a function of time and stimulation channel (stimulograms). The aim of this study was to investigate the effect of stimulation patterns on event-related potentials, such as the P300. The influence of electrode separation on the P300 response in postlingually deaf adults using a cochlear implant is demonstrated in two examples.