Miracle-dz/UniFAR-FTUs huggingface dataset:
Purpose based access control for privacy protection

Enforcement of the Sticky-policy requirement. Investigation of Fine-grained Access Control. <{G}, {T}> 94037 CA S. F. 9898 First Ave 1003 <{G}, > 46464 IL Chicago 433 State Road 1002 <{G}, {A, M}> 47907 IN W.Lafayette 232 Oval Drive 1001 addr_ip zip state city street c_id <{G}, {T}> Jack03@very.net <{G}, > Jack <{G}, > 1003 <{G}, > p23@oh.com <{G}, > Paul <{G}, > 1002 <{P, S}, {M}> john@aa.edu <{G}, {M}> John <{G}, > 1001 email_ip email name_ip name c_id_ip c_id Data + IP Labels Requirements & Privacy Laws Privacy Policies Purpose Tree
Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia.

PURPOSE The relationship of lower urinary tract symptoms (LUTS) to objective measures of benign prostatic hyperplasia (BPH), such as prostatic size and urodynamic parameters, has proved difficult to evaluate. Studies in animal models of BPH suggest that autonomic nervous system (ANS) activity is an important determinant of prostatic growth. We investigated the relationship of ANS activity to LUTS as well as to objective measures of BPH in men with BPH. MATERIALS AND METHODS This study was done in 3,047 men with LUTS secondary to BPH during screening for enrolment at 1 center in a large, multicenter, double-blind, placebo controlled trial designed to assess the long-term effects of medical therapy on BPH progression. A total of 38 men with an American Urological Association (AUA) symptom score of 8 or greater and a maximum urinary flow rate of 4 to less than 15 ml per second had ANS activity assessed based on heart rate, blood pressure, the response to circulatory stress via tilt table, and plasma and urinary catecholamine. These ANS related variables were compared with subjective measures of LUTS (AUA symptom score, quality of life score and BPH impact index), overall health measures (RAND 36-Item Health Survey) and objective clinical measures of BPH (prostate size, post-void residual volume and maximum urinary flow rate). Pearson correlation coefficients were calculated for each ANS variable vs each LUTS and BPH variable. These correlations were further assessed using stepwise multiple regression analysis to determine which BPH and LUTS variables were independently related to the ANS variable. Relationships that were identified as significant then underwent final multiple regression analysis together with control variables to exclude known extraneous and confounding influences on ANS activity. RESULTS After adjusting for extrinsic influences on ANS activity AUA symptom score (p <0.01), BPH impact index score (p <0.001) and quality of life score (p <0.05) were independently associated with the change in systolic and diastolic blood pressure 1 and 5 minutes after tilt. Additionally, prostate transition zone volume (p <0.001) and the RAND 36-Item Health Survey mental subscale score (p <0.001) were independently associated with the plasma norepinephrine response to tilt. CONCLUSIONS ANS hyperactivity is significantly associated with the most commonly used measures of LUTS, namely AUA symptom score and BPH impact index score. Also, the magnitude of the serum norepinephrine increase after tilt predicts prostate size. These relationships persist after controlling for extrinsic influences on ANS activity. The current findings may have important implications concerning the pathophysiological mechanisms underlying or influencing LUTS as well as its optimal treatment in men with BPH.
Fludarabine in combination with cyclophosphamide or with cyclophosphamide plus mitoxantrone for relapsed or refractory low-grade non-Hodgkin's lymphoma.

BACKGROUND AND OBJECTIVES We report the activity of two combinations of fludarabine (FLU), one with cyclophosphamide (FLU/CY) and the second with CY plus mitoxantrone (FLU/CY/MITO). The aim of the study was to evaluate the activity and toxicity of these two schedules in patients with non-Hodgkin's lymphoma (NHL). DESIGN AND METHODS Twenty-two patients with recurrent low grade non-Hodgkin's lymphoma (LGL) received FLU/CY (FLU 25 mg/m(2) days 1 to 3, CY 300 mg/m(2) days 1 to 3), and 31 patients received FLU/CY/MITO (FLU 25 mg/m(2) days 1 to 3, CY 300 mg/m(2) days 1 to 3, mitoxantrone 10 mg/m(2) day 1). Patients received antibiotic oral prophylaxis during all treatments and growth factors (G-CSF) when grade III granulocytopenia (WHO scale) occurred. RESULTS Of the 53 patients, 31 achieved complete remission (CR) (58%) and 16 partial remission (PR) (30%). Response was similar in both arms of the study. After 3 courses, 77% of patients who achieved CR showed a complete disappearance of disease. Seventy-nine per cent of patients experienced granulocytopenia. Few patients had fever, all without infection. One patient died with fever of unknown origin three months after completion of six courses of treatment. INTERPRETATION AND CONCLUSIONS Both treatments were seen to be effective in recurrent low-grade NHL. Antibiotic prophylaxis with G-CSF support seems to reduce treatment-related infection.
Hippocampal synaptogenesis in cell culture: developmental time course of synapse formation, calcium influx, and synaptic protein distribution

The formation of chemical synapses between hippocampal neurons in primary cell culture was studied using electrophysiology, calcium imaging, and immunocytochemical approaches. Inhibitory and excitatory synapses formed within 12 d in cell culture (DIC) that were sensitive to the N-type calcium channel blocker omega-conotoxin GVIA (omega- CgTx). At 4 DIC, immature connections were present in which spontaneous, but rarely evoked, synaptic currents were detected. At both 4 and 12 DIC, the synaptic proteins rab3a, synapsin I, and synaptotagmin were present in hippocampal neurons, but the subcellular distribution changed from one in which immunoreactivity was initially distributed within soma and neurites to a punctate varicose appearance. Correlated with the transformation from immature to mature synaptic states was the onset of omega-CgTx-sensitive calcium influx. Taken together, these data suggest that the expression of functional omega- CgTx-sensitive calcium influx is temporally coincident with synapse formation, and that during the maturation of the synapse there is a redistribution of synaptic proteins.
Niektóre własności 2-optymalnych struktur opiniowania diagnostycznego typu PMC

STRESZCZENIE: Artykuł jest kontynuacją prac [6]-[9] poświęconych strukturom opiniowania diagnostycznego (strukturom OD). Przedstawiono w nim sposób przeliczania silnie spójnych, 2-optymalnych struktur OD typu PMC (Preparata F.P., Metze G., Chien R.T. [11]) oraz wyniki przeliczenia takich struktur rzędu szóstego. Wykorzystując te wyniki oraz znajomość jawnej postaci 2-optymalnych struktur OD (typu PMC) rzędu piątego ([4], [5]), określono liczbę 2-optymalnych struktur OD (typu PMC) rzędu szóstego, których składowa silnej spójności jest rzędu piątego.
Unraveling the complexities of the HDL lipidome1

Plasma high density lipoproteins (HDL) are small, dense, protein-rich particles compared with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid components. Phospholipids predominate in the HDL lipidome, accounting for 40–60% of total lipid, with lesser proportions of cholesteryl esters (30–40%), triglycerides (5–12%), and free cholesterol (5–10%). Lipidomic approaches have provided initial insights into the HDL lipidome with identification of over 200 individual molecular lipids species in normolipidemic HDL. Plasma HDL particles, however, reveal high levels of structural, compositional, and functional heterogeneity. Establishing direct relationships between HDL structure, composition, and atheroprotective functions bears the potential to identify clinically relevant HDL subpopulations. Furthermore, development of HDL-based therapies designed to target beneficial subspecies within the circulating HDL pool can be facilitated using this approach. HDL lipidomics can equally contribute to the identification of biomarkers of both normal and deficient HDL functionality, which may prove useful as biomarkers of cardiovascular risk. However, numerous technical issues remain to be addressed in order to make such developments possible. With all technical questions resolved, quantitative analysis of the molecular components of the HDL lipidome will contribute to expand our knowledge of cardiovascular and metabolic diseases.
A mitochondrial import factor purified from rat liver cytosol is an ATP‐dependent conformational modulator for precursor proteins.

Rat liver cytosol contained an activity that stimulated the import of wheat germ lysate‐synthesized precursor proteins into mitochondria. The activity was purified 10,000‐fold from the cytosol as a homogeneous heterodimeric protein. This protein (termed mitochondrial import stimulation factor or MSF) stimulated the binding and import of mitochondrial precursor proteins. MSF was also found to recognize the presequence portion of mitochondrial precursors and catalyze the depolymerization and unfolding of in vitro synthesized mitochondrial precursor proteins in an ATP‐dependent manner; in this connection, MSF exhibited ATPase activity depending on the important‐incompetent mitochondrial precursor protein. The mitochondrial binding and import‐stimulating activities were strongly inhibited by the pretreatment of MSF with NEM, whereas the ATP‐dependent depolymerization activity was insensitive to the NEM treatment, suggesting that the process subsequent to the unfolding was inhibited with the NEM treatment. We conclude that MSF is a multifunctional cytoplasmic chaperone specific for mitochondrial protein import.
Influence of experimental rat model of multiple organ dysfunction on cefepime and amikacin pharmacokinetics

We adapted an experimental model of multiple organ dysfunction to study the alterations it induces in the pharmacology of cefepime and amikacin. The half-lives of both antibiotics were significantly prolonged because of nonsignificant enhancement of the volume of distribution and reduced renal elimination. In the presence of multiple organ dysfunction, the concentration of each antibiotic in the lungs, compared with that in the lungs of healthy controls, was significantly decreased, despite similar concentrations in plasma, indicating that the application of a standard antibiotic concentration in plasma could lead to underdosage in tissues during the initial days of therapy.
Regulation of Endothelial Junctional Permeability

The endothelium is a semi‐permeable barrier that regulates the flux of liquid and solutes, including plasma proteins, between the blood and surrounding tissue. The permeability of the vascular barrier can be modified in response to specific stimuli acting on endothelial cells. Transport across the endothelium can occur via two different pathways: through the endothelial cell (transcellular) or between adjacent cells, through interendothelial junctions (paracellular). This review focuses on the regulation of the paracellular pathway. The paracellular pathway is composed of adhesive junctions between endothelial cells, both tight junctions and adherens junctions. The actin cytoskeleton is bound to each junction and controls the integrity of each through actin remodeling. These interendothelial junctions can be disassembled or assembled to either increase or decrease paracellular permeability. Mediators, such as thrombin, TNF‐α, and LPS, stimulate their respective receptor on endothelial cells to initiate signaling that increases cytosolic Ca2+ and activates myosin light chain kinase (MLCK), as well as monomeric GTPases RhoA, Rac1, and Cdc42. Ca2+ activation of MLCK and RhoA disrupts junctions, whereas Rac1 and Cdc42 promote junctional assembly. Increased endothelial permeability can be reversed with “barrier stabilizing agents,” such as sphingosine‐1‐phosphate and cyclic adenosine monophosphate (cAMP). This review provides an overview of the mechanisms that regulate paracellular permeability.
Phosphatase-mediated heavy metal accumulation by a Citrobacter sp. and related enterobacteria.

A Citrobacter sp. was reported previously to accumulate heavy metals as cell-bound heavy metal phosphates. Metal uptake is mediated by the activity of a periplasmic acid-type phosphatase that liberates inorganic phosphate to provide the precipitant ligand for heavy metals presented to the cells. Amino acid sequencing of peptide fragments of the purified enzyme revealed significant homology to the phoN product (acid phosphatase) of some other enterobacteria. These organisms, together with Klebsiella pneumoniae, previously reported to produce acid phosphatase, were tested for their ability to remove uranium and lanthanum from challenge solutions supplemented with phosphatase substrate. The coupling of phosphate liberation to metal bioaccumulation was limited to the metal accumulating Citrobacter sp. ; therefore the participation of species-specific additional factors in metal bioaccumulation was suggested.
External ultrastructure of fruit body initiation in Morchella.

The external morphological changes occurring during initiation and early stages of fruit body development of a Morchella sp. , before the development of asci, were examined by scanning electron microscopy. Four stages of primordial development were distinguished. First, disk-shaped knots of 0.5-1.5 mm were observed on the surface of the substrate. Next, the knot inflated and a primordial stem emerged from its centre. Afterward, the stem lengthened, oriented upward, and two types of hyphal elements developed: long, straight and smooth basal hairy hyphae and short stem hyphae, some of which were inflated and projected out of a cohesive layer of tightly packed hyphal elements. Finally, when the stem was 2-3 mm long, pre-apothecia emerged in the apical end, with ridges and pits having distinguished types of paraphyses. Extracelluar mucilage covered the ridge layer and helped give the tissue its shape and rigidity.
The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease

The basis of neuronal vulnerability, degeneration, and sparing in PD are unknown, but there is increasing evidence to suggest that the ubiquitin‐proteasome system (UPS) plays an important role in the pathogenesis of the disorder. In this study, we employed an immunocytochemical approach to determine if the differential expression of key UPS components in various brain regions and cells might underlie the pattern of neuronal degeneration and survival seen in PD. We showed that the ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2), and 26/20S proteasome α‐ and β‐subunits, are abundantly expressed in the substantia nigra pars compacta (SNc) and in cultured dopaminergic neurons. Although the proteasome activator PA700 is expressed in the medial SNc, levels are low in the lateral region, and expression of the other proteasome activator, PA28, is near absent in the entire SNc. PA28 (but not PA700) was found to be poorly expressed in noradrenergic neurons in the locus coeruleus (LC) compared with adjacent cells in the mesencephalic nucleus. PA700 and PA28 are also poorly expressed in dopaminergic neurons compared with other cell types in culture. Inhibition of proteasomal function, generation of misfolded proteins, induction of oxidative stress or impairment of mitochondrial complex I activity, caused a compensatory upregulation in PA700 and PA28 in a variety of cells but not in dopaminergic neurons in culture. These findings are consistent with the demonstration that, in sporadic PD, proteasomal activity and levels of PA700/PA28 are reduced in the SNc butare markedly upregulated in regions/cells that are spared from the neurodegenerative process. Thus, the differential distribution and activity of proteasome activations could play a significant role in the pathogenesis of PD. Synapse 64:241–250, 2010. © 2009 Wiley‐Liss, Inc.
Työhyvinvointiselvitys ja suuntaviivoja työhyvinvoinnin johtamiseen asiantuntijaorganisaatiossa

28.10. 2013 Degree Programme in Modern Languages and Business Studies for Management Assistants Authors Reetta Nuopponen Group or year of entry 2010 The title of thesis Work Welfare Report and Guidelines on How to Lead Welfare at Work in an Expert Organization Number of pages and appendices 72 + 24 Supervisor(s) Soile Tuorinsuo-Byman This bachelor’s thesis examines work welfare and how to lead it in an expert organization. The overall purpose of the study was to produce a report on work welfare that covers the entire personnel of an anonymous expert organization and to give ideas on how to develop leading welfare at work. Another objective of the study was to highlight the most typical work welfare factors in an expert organization and to help understand the dynamics between two different personnel groups. The theoretical framework of the study deals with an expert organization – the various personnel groups involved, the most critical welfare factors affecting it, leading work welfare and understanding its more problematic aspects. The study was conducted in December 2012 through an electronic questionnaire, the results of which were analyzed using quantitative methods. The questionnaire was made up of four parts: work, the work community, leadership and open-response questions and background information enquiries. The results of the study help to ascertain the state of work welfare in a specific expert organization. Furthermore, the results offer valuable ideas on how to develop leading work welfare. However, it is advisable to repeat the questionnaire at some point in the future, in order to find out any possible changes needed and to guarantee the continuance of work welfare development work in this particular expert organization.
HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies

ABSTRACT The long pursuit for a vaccine against human immunodeficiency virus 1 (HIV-1) has recently been boosted by a number of exciting developments. An HIV-1 subunit vaccine ideally should elicit potent broadly neutralizing antibodies (bNAbs), but raising bNAbs by vaccination has proved extremely difficult because of the characteristics of the HIV-1 envelope glycoprotein complex (Env). However, the isolation of bNAbs from HIV-1-infected patients demonstrates that the human humoral immune system is capable of making such antibodies. Therefore, a focus of HIV-1 vaccinology is the elicitation of bNAbs by engineered immunogens and by using vaccination strategies aimed at mimicking the bNAb maturation pathways in HIV-infected patients. Important clues can also be taken from the successful subunit vaccines against hepatitis B virus and human papillomavirus. Here, we review the different types of HIV-1 immunogens and vaccination strategies that are being explored in the search for an HIV-1 vaccine that induces bNAbs.
Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis

SUMMARY Since the reclassification of the genus Bartonella in 1993, the number of species has grown from 1 to 45 currently designated members. Likewise, the association of different Bartonella species with human disease continues to grow, as does the range of clinical presentations associated with these bacteria. Among these, blood-culture-negative endocarditis stands out as a common, often undiagnosed, clinical presentation of infection with several different Bartonella species. The limitations of laboratory tests resulting in this underdiagnosis of Bartonella endocarditis are discussed. The varied clinical picture of Bartonella infection and a review of clinical aspects of endocarditis caused by Bartonella are presented. We also summarize the current knowledge of the molecular basis of Bartonella pathogenesis, focusing on surface adhesins in the two Bartonella species that most commonly cause endocarditis, B. henselae and B. quintana. We discuss evidence that surface adhesins are important factors for autoaggregation and biofilm formation by Bartonella species. Finally, we propose that biofilm formation is a critical step in the formation of vegetative masses during Bartonella-mediated endocarditis and represents a potential reservoir for persistence by these bacteria.
Schottky-barrier formation on a covalent semiconductor without Fermi-level pinning: The metal-MoS2(0001) interface.

Abstract : Chemical interaction and Schottky-barrier formation at the metal-MoS2 interface were studied by evaporating metals (Ag, Al, Au, Co, Fe, In, Mn, Pd, Rh, Ti, and V) onto the (0001) basalplane surface of cleaved molybdenite, and then analyzing the interface with x-ray photoelectron spectroscopy (XPS). Except for Mn, negligible changes were revealed in the Mo(3d(5/2) and S(2p(3/2) peak shapes, or widths, after deposition. The shifts in the blinding energies did not correlate with the electron configuration of the meal but rather with the metal electronegativity, and are interpreted in terms of band bending at the metal-semiconductor interface, rather than chemical reaction. Plot of both Mo and S binding energies versus metal electronegativity yield approximately linear curves with nonzero (positive) slopes, which provide an average index of interface behavior of S' = 1.28 + or - 0.22. This value is considerably higher than for other covalent semiconductors, which exhibit S' < 0.3 due to Fermi-level pinning. The anomalous behavior of MoS2 results from the extreme inertness of the basal-plane surface and the stability of the layered crystal lattice of MoS2. The absence of chemical interaction at the interface causes the formation of a Schottky barrier exhibiting behavior that may approach the Schottky limit. This behavior for MoS2(0001) is compared with that of other semiconductors, and is discussed in terms of their ionicity, reactivity, and dielectric response.
Challenges to implementing market orientation in the funds management industry

Market orientation has been extensively discussed in the literature however few studies have examined the challenges associated with adopting this orientation from both a firm and industry perspective. This study used depth interviews with senior marketing executives to examine the extent of market orientation in the funds management industry in Australia and the challenges associated with its implementation. The findings suggest that, despite the recognised need for market orientation, the industry is still primarily sales and product driven. Significant cultural and structural changes within the industry and individual firms are required before a market orientation can be achieved. External drivers, such as increased competition and the adoption of distribution channels which facilitate relationships with end consumers, may hasten the transition.
Photonic bands: Convergence problems with the plane-wave method.

The problems associated with the poor convergence of the Fourier transform of the hard-sphere dielectric function are discussed. A significant band gap between the eighth andninth levels has been found for air spheres in fcc. We also consider a periodic array of Gaussian spheres, which converges well and allows a consistent and reliable determination of the general features of photonic bands. It is found that when ∈(r) is sharply peaked, photonic levels become almost degenerate throughout the Brillouin zone, corresponding to standing waves