Miracle-dz/UniFAR-FTUs huggingface dataset:
Boosting bonsai trees for handwritten/printed text discrimination

Boosting over decision-stumps proved its efficiency in Natural Language Processing essentially with symbolic features, and its good properties (fast, few and not critical parameters, not sensitive to over-fitting) could be of great interest in the numeric world of pixel images. In this article we investigated the use of boosting over small decision trees, in image classification processing, for the discrimination of handwritten/printed text. Then, we conducted experiments to compare it to usual SVM-based classification revealing convincing results with very close performance, but with faster predictions and behaving far less as a black-box. Those promising results tend to make use of this classifier in more complex recognition tasks like multiclass problems.
Differences in clinical manifestations of influenza‐associated encephalopathy by age

Data from patients in Japan was analyzed to examine the age distribution and differences by age in the clinical manifestations of influenza‐associated encephalopathy. Between 1998 and 2002, 472 cases of influenza‐associated encephalopathy in patients aged 15 years or younger were reported to the Collaborative Study Group on Influenza‐Associated Encephalopathy. These cases were divided into two groups by age: 0–5 and 6–15 years. The differences between the groups were estimated based on the data for those aged 0–5 years, and the odds ratios and 95% confidence intervals calculated. Distribution was inversely correlated with age, with a peak at 1–2 years old. In comparison with patients aged 0–5, those aged 6–15 years had a significantly greater incidence of type B infection, lower frequency of convulsions, higher frequency of loss of consciousness and altered consciousness as the initial neurological symptom, lower serum transaminase levels, lower frequency of low‐density area for brain CT upon admission, and lower incidence of sequelae. Our analysis indicates that the clinical course, laboratory data, and brain imaging findings of influenza‐associated encephalopathy exhibits patterns that vary with age.
Neu-p11 reduces clock/apelin expression in insulin-resistant mouse adipocyte model.

It is generally accepted that a major risk factor of type 2 diabetes mellitus (T2DM) is insulin resistance and is often associated with obesity [1]. Apelin (expressed in adipose tissue) appears as a beneficial adipokine with anti-diabetic and antiobesity properties [2]. Clock is a large and complex gene encoding a novel member of the basic helix-loop-helix/ Per-ARNT-Sim protein family of transcription factors. Circadian clocks can regulate metabolic homeostasis and clock disruption leads to obesity and the metabolic syndrome [3]. Melatonin (Mel) is an integral part of the homeostatic mechanism in the body. It is best known as a regulator of seasonal and circadian rhythms, with high expression level during the night and low level during the day. Interestingly, insulin levels are also adapted to day/night changes through Mel-dependent synchronization. Mel may influence diabetes and be associated with metabolic disturbances by regulating insulin secretion [4]. Luzindole is the non-specific Mel receptor antagonist that can block some functions of Mel [5]. Although Mel has a wide range of biological effects, studies have found that once it gets into human body, its metabolism can be very fast, with a half-life of 20–30 min. Therefore, apparent effects cannot be achieved from direct administration of this medicine. Besides, the extraction and synthesis of Mel are relatively difficult, and some side effects may arise if its dose is too high. Neu-P11 is a new type of non-selective agonist of Mel [6]. It has the following characteristics: it can be synthesized relatively easily in vitro; its effective time can be longer with fewer side effects; it can substitute Mel to interact with its receptors, and sequentially play a wide range of biological roles. The aim of the present study was to explore the mechanism of the Mel and its receptor agonist Neu-P11 and the change of clock/apelin in insulin-resistant 3T3-L1 adipocytes. To examine the changes of clock and apelin expression levels resulted from Neu-P11 treatment, insulin-resistant 3T3-L1 adipocytes were used in this study. Neu-P11 was provided by Neurim Pharmaceuticals Ltd. (Habarzel, Israel). A 5-mM stock solution was prepared by dissolving Neu-P11 in dimethylsulfoxide. 3T3-L1 pre-adipocytes were purchased from Institute of Basic Medicine, Chinese Academy of Medical Sciences (Beijing, China). Cells were differentiated in adipogenic cocktail by 3-isobutyl-1-methylxanthine (Sigma, St Louis, USA), dexamethasone, and insulin, and identified by oil red O staining. Insulin-resistant 3T3-L1 adipocytes were induced in Dulbecco’s modified Eagle’s medium (Gibco, Gaithersburg, USA) with high glucose/ high insulin for 24 h. Glucose consumption was detected by enzymatic method to evaluate the model [7,8].
Impaired force coordination during object release in children with hemiplegic cerebral palsy

Recent studies on hand motor control in children with cerebral palsy (CP) have focused on the coordination of fingertip forces during the grasping and lifting of objects. However, little is known about the ability to replace and release an object from grasp, a function that is just as important for fine dexterity. The present study examines the coordination of fingertip forces during the replacement and release of an object (either 200 g or 400 g) from grasp in 14 children (aged between 7 and 13 years) with hemiplegic CP and in 14 age‐matched typically developing children. The results indicate that children with hemiplegic CP abruptly replaced the object but had a prolonged and uncoordinated release of the grasp. Unlike what was seen in the control children, the grip and load forces decreased sequentially in the children with CP. However, all the children could appropriately scale the rate of force decrease based on somatosensory weight‐related information from the ongoing lift. The results provide further information about the impaired hand skills in children with hemiplegic CP.
EpiTOP - a proteochemometric tool for MHC class II binding prediction

MOTIVATION T-cell epitope identification is a critical immunoinformatic problem within vaccine design. To be an epitope, a peptide must bind an MHC protein. RESULTS Here, we present EpiTOP, the first server predicting MHC class II binding based on proteochemometrics, a QSAR approach for ligands binding to several related proteins. EpiTOP uses a quantitative matrix to predict binding to 12 HLA-DRB1 alleles. It identifies 89% of known epitopes within the top 20% of predicted binders, reducing laboratory labour, materials and time by 80%. EpiTOP is easy to use, gives comprehensive quantitative predictions and will be expanded and updated with new quantitative matrices over time. AVAILABILITY EpiTOP is freely accessible at http://www.pharmfac. net/EpiTOP.
INSECT HERBIVORES AND PLANT POPULATION DYNAMICS

It is one thing to show that herbivorous insects affect plant performance. It is an entirely different matter to demonstrate that insect herbivory affects plant population dynamics. There is a vast literature on insect pests of crop plants that shows how attack by defoliating, sucking, stem-mining, and gall-forming species can delay seed ripening, reduce seed production and individual seed weights, reduce the rates of shoot and root growth, increase the susceptibility of plants to disease, and reduce the competitive ability of plants relative to their un attacked neighbors. This literature tells us virtually nothing, however, about the importance of insects in natural communities, chiefly because we have so little information on the regulation of plant populations in the wild. For example, we do not know whether plant recruitment is seed limited , so we cannot predict whether there would be an increase in plant numbers if the simple experiment of sowing extra seeds were carried out. Information on the nature of population regulation is vital because if plant recruitment is not seed limited, then insects that reduce seed production will not have an important effect on plant population dynamics. This review concentrates on material published from 1 984 to 1987. Earlier material has been covered in other reviews (36, 64, 70, 94, 1 07, 12 1 , 1 82, 206) . The first part examines the impact of insect feeding on different aspects of plant performance. The second part examines two of the best sources of evidence on the impact of insect feeding on plant population dynamics: (a) the release of specialist insect herbivores against target weed species in classical
Immunized-sir model for routing in sparse mobile Ad Hoc networks

In sparse mobile ad hoc networks, to assure the packet delivery ratio and to trim down the transmission delay is the challenging tasks while routing protocols are designed. Routing protocols for the sparse networks based on the epidemic theory had shown the improved performance in the aspect of getting better transmission successful rate and reducing the delay. In epidemic routing, messages are distributed to all the nodes whenever a node comes in contact with the other node. This leads to flooding in the network. To improve the network performance with limited utilization of the network resources is the aim of this paper. For this, we used Immunized SIR model for the design of the routing protocol.
Prevalencia de sobrepeso y obesidad en adultos de la comunidad "El Amauta". Ate - Vitarte

Materiales y metodos. Estudio tipo descriptivo, observacional y transversal que incluyo a un grupo de 51 adultos de ambos sexos entre 18 a 59 anos que residen en la comunidad “El Amauta” de Ate Vitarte. Se midio el peso y la talla y se clasifico el sobrepeso y obesidad segun los puntos de corte del indice de masa corporal propuestos por la OMS: peso adecuado (IMC de 18.5 a 24.9 kg/m2), sobrepeso (IMC de 25 a 29.9 kg/m2), y obesidad (IMC > 30.0 kg/m2).
Indium-111-pentetreotide scintigraphy in Graves' ophthalmopathy.

UNLABELLED The radiolabeled somatostatin analog 111In-pentetreotide can sensitively demonstrate somatostatin receptor-positive localizations in diseases where activated lymphocytes play a role. Lymphocyte infiltration of retrobulbar tissue in Graves' ophthalmopathy is the rationale of receptor imaging with radionuclide-coupled 111In-pentetreotide. METHODS Forty patients with Graves' ophthalmopathy, 5 patients with orbital myositis and 10 control subjects were included in this prospective study. Indium-111-pentetreotide (110 MBq) was intravenously injected and SPECT images were obtained at 4 and 24 hr after injection. The scans were analyzed by a region of interest technique. An uptake ratio between the orbits and the brain was determined. RESULTS Compared to controls (4-hr 111In-pentetreotide uptake: median 6.0 counts/voxel/MBq, orbit-to-brain ratio 5.6), ophthalmopathy patients showed two- to threefold increased uptake (15.8 counts/voxel/MBq versus controls p = 0.0032; ratio 12.6 versus controls p = 0.003). When considering patients with active disease only, even higher uptake was registered (16.8 counts/voxel/MBq versus controls p = 0.0048, ratio 15.6 versus controls p = 0.0006). Untreated patients showed markedly higher uptake (23 counts/voxel/MBq) compared to patients under steroid therapy (12.6, p = 0.001). In myositis, high uptake (20 counts/voxel/MBq) was also registered. CONCLUSION In contrast to controls, ophthalmopathy patients showed markedly increased orbital accumulation of labeled 111In-pentetreotide. This sensitive nuclear medicine technique could possibly select those patients who might benefit from treatment with immunosuppressive agents and/or octreotide.
Influence of the Counter-ion on the Absorption Isotherm for Chloride at Low Temperature.

Ioni uptake as a funiction of external concentration hlas generally been found to follow a hyperbolic relationship resembling the Freundlich or Langmuir adsorption isotherms in which uptake relative to concentrationldecreases as the external concentration rises (3). Deviations fromii this general rule can be causecl by a variety of circunmstances ancl range from a reported independence of concentration over a wide range for ioIn uptake by rye plants ( 10) to a (lirect proportionality to concentration for uptake of several ions 1y Clhlorella (7). A unique anonmaly in whiclh chloride uptake by potato disks at 00, resenmbled an exponential function of concentration was b)rieflv noted b1 Laties (8) and lhas now been further investigated.
[Poster] A Mobile Augmented reality system to assist auto mechanics

Ground-breaking technologies and innovative design of upcoming vehicles introduce complex maintenance procedures for auto mechanics. In order to present these procedures in an intuitive manner, the Mobile Augmented Reality Technical Assistance (MARTA) project was initiated. The goal was to create an Augmented Reality-aided application running on a tablet computer, which shows maintenance instructions superimposed on a live video feed of the car. Robust image-based tracking of specular surfaces using both edge and texture features as well as the software framework are the most important aspects of the project, which are presented here. The resulting application is deployed and used productively to support maintenance of the Volkswagen XL1 vehicle across the world.
El derecho humano a la participación política de las comunidades de origen inmigrante

Las concepciones de los derechos humanos predominantes a nivel mundial los tratan como derechos defensivos de los individuos para protegerse de acciones arbitrarias de las autoridades. Para ello han elaborado un complejo cuerpo normativo internacional. Sin embargo, la experiencia evidencio que, aun sin ataques a las libertades individuales, la realidad crea constantemente nuevas necesidades que deben ser satisfechas para promover la dignidad y las capacidades de los seres humanos para resistir a la opresion. Al satisfacerlas, se desarrollan los derechos humanos que entonces dejan de ser solo defensivos, para plantear politicas de reforma politica y social. En esta contribucion interesa especialmente tratar el derecho humano a la participacion politica de comunidades de origen inmigrante por sus efectos sobre el desarrollo de la ciudadania. Para ello se consideran comparativamente experiencias recogidas en Alemania, Argentina y Brasil y se sistematizan las reglas de acceso a la ciudadania bajo condiciones de heterogeneidad cultural.
Aldosterone antagonists for preventing the progression of chronic kidney disease: a systematic review and meta-analysis.

BACKGROUND AND OBJECTIVES Addition of aldosterone antagonists (AA) might provide renal benefits to proteinuric chronic kidney disease (CKD) patients over and above the inhibition of renin-angiotensin system blockers (RAS). We evaluated the benefits and harms of adding selective and nonselective AA in CKD patients already on RAS. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS MEDLINE, EMBASE, and Renal Health Library were searched for relevant randomized clinical trials in adult CKD patients. Results were summarized using the random-effects model. RESULTS Eleven trials (991 patients) were included. In comparison to angiotensin- converting enzyme inhibitors (ACEi) and/or angiotensin receptor blockers (ARB) plus placebo, nonselective AA along with ACEi and/or ARB significantly reduced 24 h proteinuria (seven trials, 372 patients, weighted mean difference [WMD] -0.80 g, 95% CI -1.27, -0.33) and BP. This did not translate into an improvement in GFR (WMD -0.70 ml/min/1.73m(2), 95% CI -4.73, 3.34). There was a significant increase in the risk of hyperkalemia with the addition of nonselective AA to ACEi and/or ARB (relative risk 3.06, 95% CI 1.26, 7.41). In two trials, addition of selective AA to ACEi resulted in an additional reduction in 24 h proteinuria, without any impact on BP and renal function. Data on cardiovascular outcomes, long-term renal outcomes and mortality were not available in any of the trials. CONCLUSIONS Aldosterone antagonists reduce proteinuria in CKD patients already on ACEis and ARBs but increase the risk of hyperkalemia. Long-term effects of these agents on renal outcomes, mortality, and safety need to be established.
Circulation retrieval of wake vortex with a side-looking scanning Lidar

Circulation is a very essential parameter to assess the intensity of a wake vortex, and there is a great demand of real time retrieval of wake vortex circulation in aviation safety and related area. In this paper, by taking into account the weak inertia of aerosols inside the wake, we present a new algorithm to retrieval the circulation of wake vortex in clear air with an up/down-ward scanning Lidar, where the circulation is boiled down to the solution of a simple system of linear equations. Application of the algorithm on measurement data from Hong Kong International Airport (HKIA) verifies the good performance of the algorithm.
Diffusion des services aux entreprises dans les systèmes urbains français et ouest-allemand

Dans un contexte europeen toujours plus pregnant, on compare les comportements des systemes urbains. L'Allemagne de l'Ouest et la France sont retenus, car chaque espace met en valeur une forme particuliere de systeme de villes : du systeme reticule ouest-allemand au systeme macrocephale francais. Observer l'evolution de la distribution spatiale des services aux entreprises sur le temps long est une maniere d'explorer l'influence de la forme des systemes de villes sur les modalites de la diffusion spatiale des innovations. Trois phases principales sont reperees, qui mettent en valeur des comportements differents, fonction de la forme du niveau metropolitain. Ainsi si le processus de diffusion est rapide lors de l'apparition de l'innovation en Allemagne de l'Ouest, il est ralenti par la suite, alors que c'est l'inverse en France.
Managing Keratoconus With Reverse-Geometry and Dual-Geometry Contact Lenses: A Case Report

Purpose. To present a case of keratoconus successfully managed with various rigid gas-permeable contact lenses with reverse-geometry and dual-geometry designs. Methods. Case report. Results. The steepest topographic keratometric readings of a 30-year-old woman with keratoconus were 62.18 diopters in the right eye and 54.70 diopters in the left eye. A conventional reverse-geometry lens worked well in the left eye. The more distorted right eye was fitted with a series of different reverse-geometry and dual-geometry lenses. Her visual acuity was 20/20 in each eye when she wore contact lenses during the day. Unaided vision was as good as 20/25+ in the right eye and 20/20 in the left eye for several hours after lens removal. No significant complication occurred during 42 months of follow-up. Conclusions. Keratoconus is a corneal disease characterized by progressive stromal thinning and ectasia, typically in the inferior cornea. Rigid gas-permeable contact lenses are the most common management option to improve vision. Corneal surgery, such as keratoplasty, is the next choice when contact lenses are ineffective or intolerable. The large overall diameter and contact area of reverse-geometry and dual-geometry lenses can assist in stabilizing the lenses on distorted corneas. These contact lenses may provide viable alternatives for management before corneal surgery.
Combination of the tod and the tol pathways in redesigning a metabolic route of Pseudomonas putida for the mineralization of a benzene, toluene, and p-xylene mixture

Construction of a hybrid strain which is capable of mineralizing components of a benzene, toluene, and p-xylene mixture simultaneously was attempted by redesigning the metabolic pathway of Pseudomonas putida. Genetic and biochemical analyses of the tod and the tol pathways revealed that dihydrodiols formed from benzene, toluene, and p-xylene by toluene dioxygenase in the tod pathway could be channeled into the tol pathway by the action of cis-p-toluate-dihydrodiol dehydrogenase, leading to complete mineralization of a benzene, toluene, and p-xylene mixture. Consequently, a hybrid strain was constructed by cloning todC1C2BA genes encoding toluene dioxygenase on RSF1010 and introducing the resulting plasmid into P. putida mt-2. The hybrid strain of P. putida TB105 was found to mineralize a benzene, toluene, and p-xylene mixture without accumulation of any metabolic intermediate.
The relative sensitivity of macrophyte and algal species to herbicides and fungicides: An analysis using species sensitivity distributions

Lemna spp. are the standard test species representing aquatic macrophytes in the current risk assessment schemes for herbicides and plant growth regulators in the European Union and North America. At a Society of Environmental Toxicology and Chemistry (SETAC) 2008 workshop on Aquatic Macrophyte Risk Assessment for Pesticides (AMRAP), a Species Sensitivity Distribution (SSD) working group was formed to address uncertainties about the sensitivity of Lemna spp. relative to other aquatic macrophyte species. For 11 herbicides and 3 fungicides for which relevant and reliable data were found for at least 6 macrophyte species, SSDs were fitted using lognormal regression. The positions of L. gibba (the most commonly tested Lemna species) and Myriophyllum spicatum (for which standardized test methods are under development) in each SSD were determined where data were available. The sensitivity of standard algal test species required for pesticide registration in the United States under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) relative to the macrophytes in each SSD was also examined (algae were not included in the SSD). L. gibba was among the most sensitive macrophyte species for approximately 50% of the chemicals examined. M. spicatum was among the most sensitive macrophytes for approximately 25% of the chemicals. In most cases, the lowest FIFRA algal species endpoint was lower than the most sensitive macrophyte endpoint. Although no single species consistently represented the most sensitive aquatic plant species, for 12 of 14 chemicals L. gibba and the FIFRA algae included an endpoint near or below the 5th percentile of the macrophyte SSD. For the other compounds, M. spicatum was the most sensitive species of all aquatic plants considered. Integr Environ Assess Manag 2013; 9: 308–318. © 2012 SETAC