Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis on mannose-binding lectin as a treatment of helicobacter pylori by using data mining

As a critical role in overall human body reactions to foreign organisms, innate immune system, especially Mannose-binding lectin (MBL), has worked for the preservation of life. Since targeted therapy on bacterial infection using innate immune system has been researched for destroying pathogens without harming ourselves, MBL could be used for the targeted therapy. Based on three algorithms; Decision Tree Algorithm, Apriori Algorithm and Support Vector Machine, analysis on chemical bond formation by comparing the similarities between two proteins which have direct relevance with mannose could suggest the potential of utilizing proteins of MBL for targeting foreign factors. According to the results, Helicobacter pylori and Homo sapiens showed distinguishable features but indicated a few common factors. We could improve the targeting treatments by considering immunological approach using MBL; to analyze the possibility for forming chemical bond between human MBL and mannose of Helicobacter pylori.
New Graduate Survey: Factors That Influence New Nurses’ Selection of First Clinical Position

Aim: The aim was to survey nurses with 2 to 3 years’ experience to determine what factors were involved in the choice of their first nursing position and if they were still in that position. Background: A false sense that the nursing shortage has ended has occurred with nurses delaying retirement until the economy improves. However, the turnover rate still shows 26% of registered nurses leaving their first hospital position within 2 years. Methods: New graduate nurses were surveyed to determine if nursing was what they expected, what led them to their first position, if they were still in their first position, and factors that may have influenced these decisions. The 159 respondents also commented on their intent to stay and gave free-text responses. Results: Significant difference was found between the current unit worked with both the unit wanted while in nursing school and the unit wanted upon graduation. Positive and negative narrative comments shed light on factors influencing intent to stay. Conclusion: Nurses are concerned with ability to deliver safe care, supportive management, and teamwork. Implications for Nursing Management: Recommendations were made for nursing management in creating an environment of continued learning and teamwork to support new graduate nurses.
Estimation of Medium Permittivity for Subsurface Radar Imaging Based on Conditional Entropy Metrics

In order to obtain a high resolution inverse synthetic aperture radar image, the kinematic parameters of the target must be estimated in order to focus the image. Entropy metrics have been a popular technique to achieve good estimates. For subsurface radar imagery, the parameter needed for focusing purposes is the permittivity of the medium. Unlike airborne radar, subsurface back scattering occurs in a noisy environment and the use of this traditional metric does not yield good results. In this paper, the authors proposed the use of a denoising technique and a conditional entropy metric that overcomes the difficulties encounter when using an entropy calculation as a focal quality indicator
The Neurotrophic Factor Artemin Promotes Pancreatic Cancer Invasion

Objective:To analyze the role of Artemin in pancreatic ductal adenocarcinoma (PDAC) in terms of expression, influence on cancer cell behavior, and pain correlation. Summary Background Data:PDAC is characterized by prominent local nerve alterations and perineural invasion, which frequently affects the extrapancreatic nerve plexus, causing severe pain and precluding curative resection. Artemin, a neurotrophic protein controlling growth, regeneration, and survival of neurons was analyzed to highlight the neuro-cancer interactions in PDAC. Methods:Artemin and its receptors (GFRα3/RET) were studied in PDAC tissues and normal pancreas by Western blot analysis and immunohistochemistry. RNA expression was analyzed in pancreatic tissues (normal, cancer) and pancreatic cancer cell lines by QRT-PCR. To evaluate whether Artemin influences cancer cell proliferation and invasion, MTT-growth and Matrigel-invasion assays were used. In addition, the tissue expression of Artemin was correlated with pain in PDAC. Results:Artemin and GFRα3/RET were both detected at enhanced levels in PDAC compared with normal pancreas, localizing predominantly in hypertrophic nerves and arterial walls, as well as in cancer cells of primary and metastatic lesions. The levels of Artemin and GFRα3 did not correlate with pain in PDAC patients. However, Artemin promoted pancreatic cancer cell invasion up to 5-fold, without affecting cancer cell proliferation. Conclusion:Artemin expression was not associated with pain in PDAC. However by increasing cancer cell invasion, Artemin seems to influence neural invasion and thereby contribute to cancer cell spreading along pancreatic nerves.
A Novel Reversed T-Match Antenna With Compact Size and Low Profile for Ultrawideband Applications

A new unidirectional antenna composed of a reversed T-match dipole, a microstrip feeding line and a ground plane is presented for low-profile ultra-wideband (UWB) applications. This antenna is an improvement over the folded dipole antenna, as it achieves a compact size and a low profile through the introduction of shorting branches on the opposite layer. Detailed descriptions of the structure and design are presented. The antenna occupies an area of 23 mm × 32 mm, and the height above the ground plane is 18 mm (about a quarter of a wavelength at mid-band). Simulated and measured results are studied and compared, which show that the proposed antenna has stable directional radiation patterns, a wide bandwidth from 2.89 GHz to 6.50 GHz, and a gain of 6.0 dBi to 9.4 dBi.
The caddisfly fauna (Insecta, Trichoptera) of the rivers of the Black Sea basin in Kosovo with distributional data for some rare species

Abstract Adult caddisflies were collected from 12 stations in the Black Sea basin in Kosovo using UV light traps. Sixty-five of the seventy-six species reported in this paper are first records for the Kosovo caddisfly fauna. The unexpected discovery of several species during this investigation: Agapetus delicatulus McLachlan, 1884, Psychomyia klapaleki Malicky, 1995, Tinodes janssensi Jacquemart, 1957, Hydropsyche emarginata Navas, 1923, Drusus botosaneanui Kumanski, 1968, Potamophylax rotundipennis (Brauer, 1857), Potamophylax schmidi Marinković-Gospodnetić, 1970, Ceraclea albimacula (Rambur, 1842), Helicopsyche bacescui Orghidan & Botosaneanu, 1953, Adicella filicornis (Pictet, 1834), Beraea maurus (Curtis, 1834) and Beraeamyia hrabei Mayer, 1937 illustrates that collections from poorly investigated areas in Europe will almost certainly revise the existing knowledge on the distribution of these and other species.
Elderly Patients and High Force Resistance Exercise—A Descriptive Report: Can an Anabolic, Muscle Growth Response Occur Without Muscle Damage or Inflammation?

Background and Purpose: Elderly individuals participate in resistance exercise to induce an anabolic response and grow muscle to help overcome functional deficits. It is thought that a muscle damage and inflammatory response to resistance exercise is a necessary prerequisite for an anabolic and muscle growth response. Methods: This is a descriptive study of 11 elderly individuals in rehabilitation who underwent a 2–3x/week high force resistance exercise that used eccentric contractions. Serum measures of muscle damage, inflammation, and an anabolic response are reported along with changes in muscle mass as measured with dual energy X‐ray absorptiometry. Results: Negative work increased >3‐fold during the 11 weeks of resistance exercise. There were no significant changes in the damage measure of serum creatine kinase (pretraining: 18.5 ± 1.2 Sigma units/ml; post‐training: 19.2 ± 1.1 Sigma units/ml). Proinflammatory tumor necrosis factor‐&agr; values remained within normal range (<4.0 pg/ml) throughout the 11 weeks of training. A nonsignificant trend for an anabolic increase (65%) in insulin like growth factor‐1 was noted along with a significant increase (6%) in thigh muscle mass. Conclusions: Neither damage, nor inflammation appear to be prerequisites for inducing anabolic and muscle growth responses in elderly individuals undergoing a high force resistance exercise with eccentric contractions.
High Precision Quantitative Angiography

Statistical considerations on the precision in the determination of blood vessel dimensions from digitized cine angiographic images are described. The resolution requirements related to "point measurements" and segmental diameter curve evaluations are discussed. The error associated with inaccurate determination of the vessel's centerline is analyzed. The concepts have been implemented on a high-speed image analyzing system, which measures blood vessel diameters with advanced automation. The performance of the system was evaluated with blood vessel phantoms, ranging in diameter from 0.88 to 6.26 mm. For these phantoms the minimum measurable change in vessel dimension over 20-pixel (-1.1 mm) long segments ranged from 3.4 to 0.2 percent, respectively.
Diffusivity of oxygen in microvascular beds as determined from PO2 distribution maps.

Dynamic changes in the distribution of PO2 in the rat mesentery were measured to determine the O2 diffusion coefficient (DO2) and consumption rate (VO2). The distribution of PO2 was obtained in two-dimensional maps by microscopic fluorometry on the basis of oxygen quenching. The corresponding vasculature was also recorded on a video recorder to analyze the PO2 distribution consistent with the arrangement of the microvessels. Anesthetized rats breathing room air were subjected to 100% O2 ventilation to induce dynamic changes in PO2 distribution. We assumed a homogenous and constant VO2 in the tissue, and a one-dimensional diffusion equation was applied to simulate oxygen transport. The PO2 data corresponded very well to the theoretical curves, and calculated DO2 was 1.04 +/- 0.78 X 10(-5) cm2/s (mean +/- SD, n = 38) and VO2 was 8.2 +/- 3.9 x 10(-6) cm3 O2.cm-3 tissue.s-1 (n = 27) at 37 degrees C. However, PO2 values at points remote from the arterioles remained higher than the theoretical prediction.
Asynchronous hatching in the burying beetle, Nicrophorus quadripunctatus, maxmizes parental fitness

Life history theory predicts that natural selection favours parents who balance investment across offspring to maximize fitness. Theoretical studies have shown that the optimal level of parental investment from the offspring's perspective exceeds that of its parents, and the disparity between the two generates evolutionary conflict for the allocation of parental investment. In various species, the offspring hatch asynchronously. The age hierarchy of the offspring usually establishes competitive asymmetries within the brood and determines the allocation of parental investment among offspring. However, it is not clear whether the allocation of parental investment determined by hatching pattern is optimal for parent or offspring. Here, we manipulated the hatching pattern of the burying beetle Nicrophorus quadripunctatus to demonstrate the influence of hatching pattern on the allocation of parental investment. We found that the total weight of a brood was largest in the group that mimicked the natural hatching pattern, with the offspring skewed towards early hatchers. This increases parental fitness. However, hatching patterns with more later hatchers had heavier individual offspring weights, which increases offspring fitness, but this hatching pattern is not observed in the wild. Thus, our study suggests that the natural hatching pattern optimizes parental fitness, rather than offspring fitness.
Neurological disorders associated with deficiency of glutamate dehydrogenase

Glutamate dehydrogenase (GDH) activity was measured in leukocytes from 88 patients with various types of degenerative neurological disorders affecting primarily the cerebellum and/or the basal ganglia, and 26 healthy control subjects. Twelve patients with slowly progressive multiple‐system atrophic disorders were found to have a partial deficiency of this enzyme (52% of control level). The majority of these patients evidenced a constellation of neurological findings consistent with the diagnosis of olivopontocerebellar atrophy, although others were atypical in their neurological manifestations. Thus, GDH‐deficient patients were encountered with predominantly extrapyramidal manifestations (atypical Parkinson's disease), cerebellar dysfunction with peripheral neuropathy, or anterior horn cell signs, suggesting that a pleomorphic phenotypic expression of the enzymatic deficiency may occur. Seven cases of GDH deficiency were familial and 5 were sporadic. The former patient group consisted of siblings of either sex, but no parents or offspring were affected. The genetic pattern of the disorder is compatible with autosomal recessive inheritance. Patients with dominantly inherited olivopontocerebellar atrophy or other types of cerebellar or basal ganglia degenerative neurological disorders showed normal GDH activity. Leukocyte GDH was fractionated into “particulate‐heat labile” and “soluble‐heat stable” components. In the patients the decrease in activity was limited to the “particulate‐heat labile” component. A genetic mutation of a GDH “isoenzyme” may occur in some patients with multiple‐system degeneration.
Anger expression and suppression among patients with essential hypertension

Abstract Objective. Hypertension (HTN) is among the seven psychosomatic diseases for which mental etiologies were proposed in 1950s. The objective of this study was to evaluate the rate of anger suppression and expression in individuals with hypertension referred to the heart clinic of “Fatemeh Zahra” Hospital, Sari, Iran. Methods. 200 patients with primary hypertension were categorized as the case group. One hundred healthy individuals older than 30 years without previous history of arterial hypertension and severe mental disorders were considered as the control group. Both groups were matched in terms of age, gender and level of education. The Spielberger questionnaire was used to assess the trait anger, anger in and anger out. The data were analyzed using SPSS software with statistical tests such as t-test, chi-square and regression. Results. The trait anger and anger suppression in patients with hypertension were significantly higher than the control group (P < 0.001); however, anger out was not significantly different between the two groups (P = 0.984). Conclusion. Considering the fact that trait anger and anger suppression is more prevalent among people with hypertension than healthy individuals, it seems suitable to provide education concerning anger management and emotional expression for these patients with regard to the anger issue which is a psychosomatic aspect of the disease.
Menopausal symptoms in women with breast cancer: Prevalence and treatment preferences

Menopausal symptoms are common and problematic for women receiving adjuvant treatment for breast cancer and management presents a challenge. This cross‐sectional descriptive study aimed to investigate the experience of menopausal symptoms, current management and treatment preferences of 113 patients with breast cancer. These women (who were prescribed tamoxifen and were on average 3 years post‐diagnosis) were recruited from a breast unit database. They completed the Hot Flush and Night Sweats Questionnaire (HFNSQ), the Women's Health Questionnaire (WHQ) and subscales of the EORTC‐QLQ‐C30 and the BR23, as well as questions about treatments. Forty‐four of this sample were also interviewed. The prevalence of hot flushes and night sweats was 80 and 72%, respectively (average 30 per week). Having more problematic hot flushes and night sweats were associated with more anxiety and sleep problems (WHQ), and with poorer emotional and social functioning and worse body image (EORTC‐QLQ‐C30). The women had used a range of treatments for menopausal symptoms but there was often no evidence for the efficacy for many of these treatments. Strongest preferences were for non‐medical treatments, particularly vitamins and herbal remedies and cognitive behavioural therapy (CBT). The evidence for the effectiveness of the former is weak, whereas CBT has been shown to reduce menopausal symptoms, but needs to be evaluated in a population of women who have been treated for breast cancer. Copyright © 2004 John Wiley & Sons, Ltd.
Interval methods based AUV localization in the context of an acoustic network with experimental results

This article presents an application of interval methods for the dynamic localization of an autonomous underwater vehicles (AUV) using acoustic measurements of range and/or bearing to one or more underwater or surface nodes. A node can be either a vehicle or a buoy equipped with an acoustic modem and positioning aid. The position and speed vector of each node is communicated acoustically underwater to all of the other nodes. Popular methods used in solving localization problems use a probabilistic approach (e.g. Kalman filtering or Particle filtering). While such methods consider the probabilistic distribution of variables, the interval methods consider sets of possible values of a variable. The interval methods are deterministic in nature and have certain advantages over probabilistic methods such as native handling of non linear equations or solving problems of high dimension, guaranteed result under the right assumptions, and handling inconsistent data. The interval localization method is tested on a dataset acquired during an experiment on the Mediterranean sea.
Determinants of Research and Development Intensity from a Network Perspective

Abstract We model and examine the research and development (R&D) intensity of a focal industry from an inter-industry network perspective. More specifically, we estimate how a focal industry’s R&D investment is affected by partner (suppliers and customers) industries’ R&D expenditure. We also investigate the impact of the overall economy on the focal industry’s R&D expenditure and finally how a focal industry’s position in the supply chain network moderates the overall economy’s impact on the focal industry’s R&D expenditure. We found that, in general, a focal industry’s R&D intensity is positively associated with its partner industries’ R&D intensity. In addition, an industry’s R&D intensity is positively associated with the growth rate of the overall economy. Finally, we found that a more central industry is subjected to a stronger impact of macroeconomic shocks on its R&D intensity though there is no significant association between an industry’s centrality and its R&D intensity.
Rice phosphate transporters include an evolutionarily divergent gene specifically activated in arbuscular mycorrhizal symbiosis

Using a genome-wide approach, we asked how many transporter genes contribute to symbiotic phosphate uptake and analyzed their evolutionary conservation. Considering the sequenced rice genome at hand, only the Oryza sativa phosphate transporter (OsPT) gene OsPT11 was specifically induced during the arbuscular mycorrhizal symbiosis. This induction was confined to the root system and was tightly correlated with the degree of root colonization by Glomus intraradices. OsPT11 activation was independent of the nutritional status of the plant and phosphate availability in the rhizosphere. Moreover, infection of roots with the fungal pathogens Rhizoctonia solani and Fusarium moniliforme did not activate OsPT11, corroborating the high signal specificity for OsPT11 activation in the arbuscular mycorrhizal symbiosis. OsPT11 expression complemented a defect in phosphate uptake in a yeast strain mutated in its high-affinity Pi transporter (pho84), thereby confirming its function. Recently, a phosphate transporter gene in potato was shown to be induced during arbuscular mycorrhizal symbiosis. Assessment of the phylogenetic relationship of the rice and potato protein revealed that the rice is nonorthologous to the potato protein. Further, there are no structural commonalities in the promoter regions. Thus, although cytological and physiological features of the arbuscular mycorrhizal symbiosis seem to be conserved, the molecular components may differ significantly between distantly related plant species.
Using the input-output model in macroeconomic analysis and forecasting studies

In this article the authors present the main aspects of a country's macroeconomic system. It shows that it is a complex structured economic sectors (pure sectors). Also it makes reference to the free market, placing the problem of identifying the interaction of market forces. Inside the national economy there is an intermediate consumption that is showing the amount consumed by branch "c" from all other branches. Input fields are used in this respect in order to show that at a macroeconomic level the model is complex, on the basis of the model calculation and analysis of economic is performed. On the basis of coefficients the existence and intensity of links between branches of national economy is determined. It is important to establish the how aggregation of branches is taking place. The number of branches and the concentration degree are subordinate requirements of study links and proportions that are performed in an economic activity. Aggregation of activities in order to establish the branches used for creating input-output tables is made according to several criteria such as: product identification, common destination of the finished product, similarity raw materials consumed or technological processes and likeness of quantitative structure cost price of production. The branches for the balance should be homogeneous and represent a grouping of homogeneous production units.
Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage

Mice deficient in early B cell factor (EBF) are blocked at the progenitor B cell stage prior to immunoglobulin gene rearrangement. The EBF‐dependent block in B cell development occurs near the onset of B‐lineage commitment, which raises the possibility that EBF may act instructively to specify the B cell fate from uncommitted, multipotential progenitor cells. To test this hypothesis, we transduced enriched hematopoietic progenitor cells with a retroviral vector that coexpressed EBF and the green fluorescent protein (GFP). Mice reconstituted with EBF‐expressing cells showed a near complete absence of T lymphocytes. Spleen and peripheral blood samples were >95 and 90% GFP+EBF+ mature B cells, respectively. Both NK and lymphoid‐derived dendritic cells were also significantly reduced compared with control‐transplanted mice. These data suggest that EBF can restrict lymphopoiesis to the B cell lineage by blocking development of other lymphoid‐derived cell pathways.