Miracle-dz/UniFAR-FTUs huggingface dataset:
Stroke and Myocardial Infarction: A Comparative Systematic Evaluation of Gender-Specific Analysis, Funding and Authorship Patterns in Cardiovascular Research

Background: Major gender differences exist in cardiovascular diseases and lead to different outcomes in women and men. However, attention and incorporation of sex-/gender-specific research might vary among disciplines. We therefore conducted a systematic review comparing publication characteristics and trends between stroke and myocardial infarction (MI) with respect to sex- and gender-related aspects. Methods: A systematic literature search was performed in PubMed to identify gender-/sex-related articles published for stroke and MI between 1977 and 2008. A specifically designed text mining program was used, and all literature was rated by two independent investigators. Publications were classified according to type of research performed, publication year, funding, geographical location, and gender of first and last authors. Results: 962 articles were retrieved and limited to 405 (42%) gender-relevant publications; 131 on stroke and 274 on MI. Type of performed research differed, especially in disease management, which received little attention (17%) in stroke, while representing the major focus in MI (40%). In both areas, clinical presentation received little attention (3 and 5%). Although publications progressively increased in both fields, an 8- to 10-year time gap emerged for stroke compared to MI. Last authors in both areas were predominantly men, but female last authorship is increasing more significantly over time in the field of stroke. Research on sex and gender differences in MI and stroke is largely underfunded, particularly by the EU. Conclusions: The data demonstrate how sex-/gender-specific research differs between specialties, most likely due to the diverse interest, funding opportunities and authorship distributions identified.
Implementation of Internet of Things in the market of Bosnia and Herzegovina: Business market and technological review

The potential benefits of Internet of Things (IoT) are numerous and diverse spreading through all areas of everyday life of individuals, enterprises and society as a whole. Telecommunications sector enjoys a central role in the world of IoT because of owning communication infrastructure and already built relationship of trust with a variety of users including control of large amounts of data about them and their online activities. The growth of IoT requires the change of current communication infrastructure including wireless and wired networks being used in order to fulfill the market needs. In order to provide scalability and flexibility which are required by the market to maximize the potential of IoT, the standardization is needed. Therefore, this paper is intended to the telecommunication sector of Bosnia and Herzegovina with the aim to highlight the importance of necessity of coordinated development of business models and communication infrastructure according to the relevant standards and market needs.
Genetics and cardiac channelopathies

Abstract: Sudden cardiac death is a major contributor to mortality in industrialized nations; in fact, it is the cause of more deaths than acquired immune deficiency syndrome, lung and breast cancer, and stroke together. Frequently, the autopsy becomes the principal diagnostic tool because macroscopic and microscopic analyses reveal the underlying cause of death. However, a significant number of sudden cardiac deaths remain unexplained. These cases are referred to as “natural” or arrhythmogenic. In the young, in up to 50% of sudden cardiac death cases, sudden death is the first and only clinical manifestation of an inherited cardiac disease that had remained undetected by conventional clinical investigations. To improve diagnosis, genetic testing has recently been added to these clinical tools. During the last two decades, there has been considerable progress in the understanding about genetics of sudden cardiac death. With that new information, the probands and their family members can make an informed decision regarding their care and know whether and to what extent they are at risk of suffering from the disease. Thus, genetic technology and expertise have become essential for the diagnosis of some forms of inherited cardiac diseases and to provide a basis for subsequent prevention strategies. This review focuses on recent advances in the understanding of cardiopathies owing to genetic investigations.
Role of milk fractions, serum, and divalent cations in protection of mammary epithelial cells of cows against damage by Staphylococcus aureus toxins.

OBJECTIVE To determine the effect of milk and blood serum constituents on cytotoxicity of Staphylococcus aureus on mammary epithelial cells. DESIGN In vitro incubation of cells with cytotoxic agents and milk and serum constituents. SAMPLE POPULATION Mammary cells, milk, and blood obtained from 3 cows. PROCEDURE Staphylococcal alpha-toxin and culture supernatants from S aureus M60 and an alpha-toxin-negative mutant of M60 were incubated with bovine mammary epithelial cells in the presence of milk fractions, serum, and divalent cations. Propidium iodide fluorescence was used as a measure of cell damage. RESULTS Skim milk and milk whey inhibited S aureus cytotoxic agents. Skim milk protected against alpha-toxin damage to a greater extent than milk whey. Serum from an adult animal was more protective than was fetal serum. Milk fat and serum albumin had no protective effect. Divalent calcium and Mg2+ were more effective inhibitors of mammary epithelial cell damage caused by alpha-toxin than of damage attributable to M60 culture supernatant. Divalent calcium and Mg2+ at concentrations similar to those of free Ca2+ and Mg2+ in normal bovine milk decreased cytotoxic damage attributable to alpha-toxin. However, concentrations similar to those of total Ca2+ and Mg2+ in normal milk were required to decrease cell damage caused by M60 culture supernatant. The alpha-toxin-negative mutant was less cytotoxic than the M60 parent strain. CONCLUSIONS Casein, as well as Ca2+ and Mg2+ in bovine milk, inhibit the cytotoxic effect of S aureus on mammary epithelial cells.
Resolution of fatty liver and risk of incident diabetes.

CONTEXT Fatty liver is associated with an increased risk of type 2 diabetes, but whether an increased risk remains in people in whom fatty liver resolves over time is not known. OBJECTIVE The objective of the study was to assess the risk of incident diabetes at a 5-year follow-up in people in whom: 1) new fatty liver developed; 2) existing fatty liver resolved, and 3) fatty liver severity worsened over 5 years. DESIGN AND METHODS A total of 13,218 people without diabetes at baseline from a Korean occupational cohort were examined at baseline and after 5 years, using a retrospective study design. Fatty liver status was assessed at baseline and follow-up as absent, mild, or moderate/severe using standard ultrasound criteria. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for incident diabetes at follow-up were estimated after controlling for multiple potential confounders. RESULTS Two hundred thirty-four people developed incident diabetes. Over 5 years, fatty liver resolved in 828, developed in 1640, and progressed from mild to moderate/severe in 324 people. Resolution of fatty liver was not associated with a risk of incident diabetes [aOR 0.95 (95% CIs 0.46, 1.96), P = . 89]. Development of new fatty liver was associated with incident diabetes [aOR 2.49 (95% CI 1.49, 4.14), P < . 001]. In individuals in whom severity of fatty liver worsened over 5 years (from mild to moderate/severe), there was a marked increase in the risk of incident diabetes [aOR 6.13 (2.56, 95% CI 14.68) P < . 001 (compared with the risk in people with resolution of fatty liver)]. CONCLUSION Change in fatty liver status over time is associated with markedly variable risks of incident diabetes.
Security First: The New Right-Wing Government in Poland and its Policy towards Immigrants and Refugees

The so-called refugee crisis in 2015 coincided with the Polish parliamentary electoral campaign. The effect of it was—for the first time in Poland—the introduction of migration policy to the political agenda of the right-wing and populist political parties on a massive scale. They presented migration as an issue of security—both national and cultural, direct and symbolic. The new government, acting since the end of 2015, included immigration and asylum issues into their political programme as a key element of national security. Their discourse about refugees is usually based on the differentiation: us and them. And ‘them’ are pictured as evil, dangerous, Muslim terrorists. The new government and its authoritarian style of governing has introduced a number of initiatives designed to deprive individuals of immigrant rights (like in the new so-called Antiterrorist Act from the mid of 2016, based on which every foreign citizen could be put under surveillance without any court control) or to stop refugee influx on the Polish territory in any way—directly from their country of origin (new amendments to asylum law are trying to introduce border and accelerated procedures) or under the UE resettlement and relocation programme (Poland is one of 3 EU Member States—along Hungary and Austria—that hasn’t relocated anyone). In this paper I will present in more detail the legal changes described above, their consequences and the so-called rationalities presented by the government.
The issues of public participation in garden design process: an analytical discourse

This paper will try to reveal issues and problem in garden design process. The research applies content analysis to review some problems of public participation in garden design expressly to discourse specific issues and problems surrounding the design and space of garden design in urban fabric. The section discuss general picture concerning importance of public participation id garden design process to achieve a consensus for a better quality garden for public and community. It is anticipated that through this paper we can comprehend issues and problems of public participation in garden design process and reference frameworks in reconstructing its space for the present and the future.
Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis‐prone population

Anergic/suppressive CD4+CD25+ T cells exist in animal models but their presence has not yet been demonstrated in humans. We have identified and characterized a human CD4+CD25+ T cell subset, which constitutes 7–10 % of CD4+ T cells in peripheral blood and tonsil. These cells are a CD45RO+CD45RBlow highly differentiated primedT cell population that is anergic to stimulation. Depletion of this small subset from CD4+ T cells significantly enhances proliferation by threefold in the remaining CD4+CD25– T cells, while the addition of isolated CD4+CD25+ T cells to CD4+CD25– T cells significantly inhibits proliferative activity. Blocking experiments suggest that suppression is not mediated via IL‐4, IL‐10 or TGF‐β and is cell‐contact dependent. Isolated CD4+CD25+ T cells are susceptible to apoptosis that is associated with low Bcl‐2 expression, but this death can be prevented by IL‐2 or fibroblast‐secreted IFN‐β. However, the anergic/suppressive state of these cells is maintained after cytokine rescue. These human regulatory cells are therefore a naturally occurring, highly suppressive, apoptosis‐prone population which are at a late stage of differentiation. Further studies into their role in normal and pathological situations in humans are clearly essential.
Bi-functional metasurface controlling electromagnetic wave scattering of differently polarized wave

We proposed an anisotropic metasurface performing different scattering properties depending on the polarization of the incident electromagnetic wave. The proposed metasurface is composed of orthogonally I-shaped structures with a thickness of only 0.067 working wavelength, and the reflection phase for certain linearly polarized incidence can be independently controlled by tuning the corresponding geometric parameters. Based on this principle we designed a bi-functional metasurface for differently polarized wave. It can behave as a phase-compensation planar reflector to transform the primary out-phase radiation from an x-polarized feeding antenna into a secondary planar wavefront with high directivity reaching 22 dBi. On the other hand, it behaves as a diffuse reflector composed of randomly distributed reflection phases to suppress the backward radar cross section in a broad band (8.2 GHz–12.5 GHz) under the illumination of y-polarized incident wave.
Occurrence and Prevalence of Clostridium perfringens in Polar Bears from Svalbard, Norway

To obtain insight into the occurrence and prevalence of Clostridium perfringens and its major toxins in polar bears (Ursus maritimus), we took fecal samples for bacteriologic analysis from live-captured bears in the Svalbard Archipelago, Norway, in 2001. Clostridium perfringens was isolated from 40 of 92 samples (44%). Thirty strains were further characterized by determining toxin type and were classified to be type A, while one was also positive for the gene encoding β2-toxin. Despite the fact that C. perfringens type A has been associated with fatal diseases in several animal species as well as in humans, our data indicate that C. perfringens type A is an normal inhabitant of the gastrointestinal tract of polar bears.
Induction of p21/WAF1 and G1 cell‐cycle arrest by the chemopreventive agent apigenin

Apigenin is a plant flavonoid that has been shown to significantly inhibit ultraviolet‐induced mouse skin tumorigenesis when applied topically and may be an alternative sunscreen agent for humans. A long‐term goal of our laboratory is to elucidate the molecular mechanism or mechanisms by which apigenin inhibits skin tumorigenesis. In a previous publication, we characterized the mechanism by which apigenin induced G2/M arrest in keratinocytes. More recent studies in our laboratory have provided evidence that apigenin can induce G1 arrest in addition to arresting cells at G2/M. Here we describe the mechanism of the apigenin‐induced G1 arrest in human diploid fibroblasts (HDF). Treatment of asynchronous HDF for 24 h with 10–50 μM apigenin resulted in dose‐dependent cell‐cycle arrest at both the G0/G1 and G2/M phases as measured by flow cytometry. The G0/G1 arrest was more clearly defined by using HDF that were synchronized in G0 and then released from quiescence by replating at subconfluent densities in medium containing 10–70 μM apigenin. The cells were analyzed for cell‐cycle progression or cyclin D1 expression 24 h later. A dose of apigenin as low as 10 μM reduced the percentage of cells in S phase by 20% compared with control cultures treated with solvent alone. Western blot analysis of apigenin‐treated HDF indicated that cyclin D1 was expressed at higher levels than in untreated cells, which signifies that they were arrested in G1 phase rather than in a G0 quiescent state. The G1 arrest was further studied by cyclin‐dependent kinase 2 (cdk2) immune complex–kinase assays of apigenin‐treated asynchronous HDF, which demonstrated a dose‐dependent inhibition of cdk2 by apigenin. Inhibition of cdk2 kiase activity in apigenin‐treated cells was associated with the accumulation of the hypophosphorylated form of the retinoblastoma (Rb) protein as measured by western blot analysis. The cdk inhibitor p21/WAF1 was also induced in a dose‐dependent manner, with a 22‐fold induction of p21/WAF1 in 70 μM apigenin‐treated cells. In conclusion, apigenin treatment produced a G1 cell‐cycle arrest by inhibiting cdk2 kinase activity and the phosphorylation of Rb and inducing the cdk inhibitor p21/WAF1, all of which may mediate its chemopreventive activities in vivo. To our knowledge this is the first report of a chemopreventive agent inducing p21/WAF1, a known downstream effector of the p53 tumor suppressor protein. Mol. Carcinog. 19:74–82, 1997. © 1997 Wiley‐Liss, Inc.
SAR imagery applied to the monitoring of hyper-saline deposits: Death Valley example (CA)

The present study aims at understanding the influence of salinity on the dielectric constant of soils and then on the backscattering coefficients recorded by airborne / spaceborne SAR systems. Based on dielectric measurements performed over hyper-saline deposits in Death Valley (CA), as well as laboratory electromagnetic characterization of salts and water mixtures, we used the dielectric constants as input parameters of analytical IEM simulations to model both the amplitude and phase behaviors of SAR signal at C, and L-bands. Our analytical simulations allow to reproduce specific copolar signatures recorded in SAR data, corresponding to the Cottonball Basin saltpan. We also propose the copolar backscattering ratio and phase difference as indicators of moistened and salt-affected soils. More precisely, we show that these copolar indicators should allow to monitor the seasonal variations of the dielectric properties of saline deposits.
A review on road accident data analysis using data mining techniques

Road accident analysis plays an important role in transportation system. This paper shows a survey of road accident analysis methods in data mining. In the data mining there is no. of techniques available for clustering and classification, from those techniques k-mean, association rule, SVM, Weka tool was used in previously research for road accident analysis. In our daily life there are no. of accident increases and it is big problem to us because no. of people death and injured for that improve the road transportation system is needed. In this research self organization map (SOM) is used for find a no. of pattern to analysis the road accident data which help to find prediction of accident reasons and improve the accuracy of analysis compare to k-means clustering algorithm. With the help of SOM, clusters are created and analyze them. Self Organizing map method is based on neural network, it is used as an unsupervised learning method. It will help to improve analysis accuracy.
Causalidade entre os retornos contábeis e os retornos do mercado de ações brasileiro

espanolEsta investigacion tiene como objetivo investigar en el ambito del mercado accionario brasileno la relacion de causa y efecto entre el retorno contable (ROE) y el retorno del mercado de acciones (RET) en Brasil. Analizamos la precedencia temporal y buscando evidencias sobre la capacidad predictiva. El estudio se basa en una investigacion empirica sobre la relacion de causa y efecto entre el retorno contable (ROE) y el retorno del mercado de acciones (RET), utilizando para ello la prueba de causalidad de Granger. La muestra para realizacion del estudio esta formada con los datos de las empresas listadas en la BM&FBovespa en el periodo de 1995 hasta 2009 en frecuencia trimestral extraidas del banco de datos de la Economatica. Los resultados indican que en general no existen evidencias de causalidad entre el RET y el ROE en ninguna direccion, no siendo posible apuntar en esos casos precedencia temporal, lo que demuestra el bajo poder de mejora de la varianza de la prevision con la inclusion de una de las variables EnglishThis research aims to investigate within the scope of the Brazilian stock market the cause and effect relationship between the accounting rate-of-return (ROE) and the return of the stock market (RET) in Brazil. Analyzes temporal precedence and looks for evidence on predictive capacity. The study is based on an empirical investigation of the cause and effect relationship between the accounting rate-of-return (ROE) and the stock market return (RET), using the Granger causality test. The sample for the study is formed with the data of the companies listed on the BM&FBovespa from 1995 to 2009 in quarterly frequency extracted from the Economatica database. The results indicate that, in general, there is no evidence of causality between RET and ROE in either direction. It is not possible to indicate in these cases temporal precedence. This demonstrates the low power of improvement of the forecast variance with the inclusion of one of the variables. portuguesEsta pesquisa tem como objetivo investigar no âmbito do mercado acionario brasileiro a relacao de causa e efeito entre o retorno contabil (ROE) e o retorno do mercado de acoes (RET) no Brasil, analisando precedencia temporal e procurando evidencias sobre a capacidade preditiva. O estudo e baseado em uma investigacao empirica sobre a relacao de causa e efeito entre o retorno contabil (ROE) e o retorno do mercado de acoes (RET), utilizando para isso o teste de causalidade de Granger. A amostra para realizacao do estudo e formada com os dados das empresas listadas na BM&FBovespa no periodo de 1995 ate 2009 em frequencia trimestral extraidas do banco de dados da Economatica. Os resultados indicam que em geral nao existem evidencias de causalidade entre o RET e o ROE em nenhuma direcao, nao sendo possivel apontar nesses casos precedencia temporal, o que demonstra o baixo poder de melhoria da variância da previsao com a inclusao de uma das variaveis.
Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum.

BACKGROUND Passively acquired maternal antibodies protect infants from many pathogens. With increasing reports of infant pertussis, we evaluated pertussis antibodies in maternal-infant paired sera from 1999-2000. METHODS Antibodies to pertussis toxin (PT), filamentous hemagglutinin (FHA), and fimbrial proteins (FIM) were measured by validated IgG-specific enzyme-linked immunosorbant assay (ELISA) in 64 maternal-umbilical cord serum pairs and in 61 of 64 infant sera. Geometric mean concentrations (GMCs) of pertussis antibodies and cord : maternal GMC ratios were calculated. RESULTS Mean maternal age and gestation were 29.7 years (range, 19-42) and 39.3 weeks (range, 35.6-40.9), and 81% of mothers were white. GMCs of maternal antibodies at delivery (ELISA units/mL) were 2.4 for PT, 6.9 for FHA, and 13 for FIM. Cord GMCs were 169%, 178%, and 157% of maternal delivery values for PT, FHA, and FIM, respectively, demonstrating active placental transfer (P<.001). Pertussis-specific IgG values for each antigen decayed to below the threshold of detection by age 2 months. CONCLUSIONS Despite efficient placental transfer, low maternal pertussis antibody levels and their rapid decay in infant sera leave infants with little humoral protection against pertussis. These data support the rationale for maternal or neonatal immunization, with acellular pertussis vaccines, to prevent life-threatening pertussis in early infancy.
Charging of electric vehicles and demand response management in a Singaporean car park

Uncontrolled charging of electric vehicles can affect the power system operation and stability. In cities with high population density and with short driving distances like Singapore, car parks bear a high proportion of private vehicles most of the day. These car parks can be regarded as aggregators and control the charging process. Demand response could be used by the car park operators as an additional source of revenue and thus help offset the high installation costs. This paper investigates different charging strategies and demand response management possibilities within a specific car park. Data for arrival times and parking durations are obtained using available statistical information, charging of individual electric vehicles is controlled by the car park operator and effects of demand response management on the total charging cost of the system is analysed.