Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcome und Evaluation von Risikoscores bei organtransplantierten Patienten einer medizinischen Intensivstation

Patienten nach Organtransplantation sind eine wachsende Gruppe immunkompromittierter Menschen mit generell steigender Lebenserwartung. Sie weisen jedoch ein erhohtes Risiko fur lebensbedrohliche Komplikationen wie Infektionen, Transplantatversagen oder kardiovaskulare Erkrankungen auf, weswegen sie auf eine Intensivstation aufgenommen werden. Uber Verlauf und Outcome dieser speziellen Patientengruppe auf einer medizinischen Intensivstation ist wenig bekannt. Wir fuhrten deshalb eine retrospektive Kohortenanalyse von Patienten nach solider Organtransplantation durch, welche zwischen 2000 bis 2004 auf der medizinischen Intensivstation des UniversitatsSpitales Zurich hospitalisiert waren. Wir unter-suchten total 99 Patienten im Alter von 53 Jahren, welche durchschnittlich 62 Monate nach Transplantation auf die Intensivstation eintraten. 61 Patienten waren nieren- (62%), 16 (16%) lungen-, 15 (15%) herz- und 7 (7%) lebertransplantiert. Die haufigste Eintrittsdiagnose betraf kardiovaskulare Probleme. Die Mortalitat wahrend des IPS-Aufenthaltes betrug 14.4% und in den nachfolgenden sechs Monate 5.6% (total 20%). Die 30 und 180 Tage Uberlebenswahrscheinlichkeiten waren 85% (95-CI 79-91%) respektive 78% (95-CI 71-85%). Bezuglich Gesamtuberleben zeigte sich kein signifikanter Unterschied zwischen den verschiedenen Transplantationsgruppen, sowohl wahrend des IPS-Aufenthaltes (p=0.11) wie auch wahrend der sechsmonatigen Follow-up Periode (p=0.577). Die haufigste Todesursache waren Infektionen. Der Bedarf an Vasopressoren, der Einsatz mechanischer Beatmung und ein erhohtes Bilirubin korrelierten signifikant mit der Mortalitat auf der Intensivstation und sechs Monate nach IPS-Entlassung. Transplantatversagen und Hamodialyse waren Risikofaktoren fur die IPS-Mortalitat, wahrend die nicht-invasive Beatmung kein Risikofaktor darstellte. Die Risikoscores - MODS, SOFA und SAPS II - zeigten vergleichbare Ergebnisse und erlauben eine Diskriminierung von intensivpflichtigen organtransplantierten Patienten bezuglich Uberleben. Von den total 5650 IPS Eintritten wahrend der 5 jahrigen Untersuchung stellten Patienten nach solider Organtransplantation mit lediglich 160 Eintritten (2.8%) eine Minderheit dar, nehmen aber durch ihre Immunsuppression eine besondere Rolle ein. Sie leiden oft an spezifischen transplantatassoziierten Komplikationen. Mortalitat, Aufenthaltsdauer und Risikoscores dieser Patienten unterscheiden sich jedoch, gemass unserer Untersuchung, nicht von der allgemei-nen, gesamten IPS-Population.
End-of-life care in UK care homes: a systematic review of the literature

Background The number of people requiring end-of-life care provision in care homes has grown significantly. There is a need for a systematic examination of individual studies to provide more comprehensive information about contemporary care provision. Aim The aim of this study was to systematically review studies that describe end-of-life care in UK care homes. Method A systematic PRISMA review of the literature published between 2008 and April 2017 was carried out. A total of 14 studies were included in the review. Results A number of areas of concern were identified in the literature in relation to the phases of dying during end-of-life care: end-of-life pre-planning processes; understandings of end-of-life care; and interprofessional end-of-life care provision. Conclusions Given that the problems identified in the literature concerning end-of-life care of residents in care homes are similar to those encountered in other healthcare environments, there is logic in considering how generalised solutions that have been proposed could be applied to the specifics of care homes. Further research is necessary to explore how barriers to good end-of-life care can be mitigated, and facilitators strengthened.
Why Crossmatch Tests are Very Important and What Do They Tell Us?

Organ transplantation is a very complex procedure that can save lives. It is a very useful procedure if the concepts of immunology, gained through bitter experience over the years, are kept in mind during practice. Allogeneic sensitization due to previous exposure(s) to alloantigens can hamper the procedure and remains the main obstacle to organ transplantation. Allosensitization and its level in a patient can be revealed before transplantation using the crossmatch test performed by incubating the patient’s serum with the possible donor’s lymphocytes in a laboratory environment. Crossmatch tests are routinely used prior to transplantation to prevent acute humoral reactions to the allograft tissue following reperfusion and also for long-term monitoring of the patient’s humoral status during the preand post-transplantation periods.
Low Income Urban Forestry Program in Tucson, Arizona, USA

Low Income Urban Forestry Program in Tucson, Arizona, USA Theresa Foley PhD Sonora Environmental Research Institute, Inc. (SERI), theresa.foley3@gmail.com Ann Marie Wolf Sonora Environmental Research Institute, Inc. (SERI), annmarie@seriaz.org Palmira Henriquez Sonora Environmental Research Institute, Inc. (SERI), phenriquez@seriaz.org Flor Sandoval Sonora Environmental Research Institute, Inc. (SERI), moralesf@seriaz.org Alix Rogstad University of Arizona, alix@email.arizona. edu
Hubungan Asupan Vitamin C dengan Kadar Glukosa Darah Puasa pada Lansia Diabetes Melitus Tipe 2 di Paguyuban Diabetes Melitus Surakarta

Hyperglycemia is a clinical manifestation of the occurrence of diabetes type 2 due to insulin resistance. Hyperglycemia can cause oxidation of LDL by free radical so that can increase LDL levels. Giving antioxidants are known to suppress the oxidation of the LDL. One of the lipophilic antioxidant that can prevent the oxidation of LDL is β-carotene. This study aimed to determine the effect of β-carotene supplementation dose of 10 mg / kg for 30 days with a frequency of once every 2 days blood cholesterol levels Wistar male rats Streptozotocin-induced diabetes mellitus and Nicotinamide. Research methodology used a total of 18 male Wistar rats were randomized design with pre and post test randomized controlled group design form the three groups of X1 (non-diabetic); X2 (STZ-induced rat 45 mg / kg and NA 110 mg / kg); X3 (diabetic rats treated β-carotene 10 mg / kg). β-carotene is given by way of a sonde with a frequency of once every 2 days for 30 days. Blood glucose levels are checked using GOD-PAP method and LDL precipitation reagent diperiksan method for in-vitro determination of LDL Cholesterol with CHOD-PAP on photometric system. Analysis of data using statistical test paired t-test and one way ANOVA. The result showed there were significant differences in decreased levels of LDL in male rats Wistar (p = 0.000) post-treatment of β-carotene supplementation of 10 mg / kg in a sonde for 30 days with a frequency of once every two days.
Integrating safety and mobility for pathfinding using big data generated by connected vehicles

Abstract With the emergence of the internet of things, pathfinding problems have recently received a significant amount of attention. Various commercial applications provide automated routing by considering travel time, travel distance, fuel consumption, complexity of the road, etc. However, many of these prospective applications do not consider route safety. Emergence of high-resolution big data generated by connected vehicles (CV) helps us to integrate safety into routing problem. The goal of this study is to address safety aspects in pathfinding problems by developing a methodological framework that simultaneously considers safety and mobility. To reach this goal, the concept of volatility is utilized as a surrogate safety performance measure to quantify route safety and driver behavior. The proposed framework uses CV big data and real-time traffic data to calculate safety indices and travel times. Measured safety indices include 5-year crash history, route speed and acceleration volatility, and driver volatility. Travel time and safety shape a cost function called “route impedance. ” The algorithm has the flexibility for the user to predefine the weight for safety consideration. It also uses driver volatility to automatically increase safety weight for volatile drivers. To illustrate the algorithm, a numerical example is provided using an origin-destination pair in Ann Arbor, MI, and more than 42 million CV observations from around 2,500 CVs from the Safety Pilot Model Deployment (SPMD) were analyzed. The sensitivity analysis is performed to discuss the impact of penetration rate of CVs and time of the trip on the results. Finally, this paper shows suggested routes for multiple scenarios to demonstrate the outcome of the study. The results revealed that the algorithm might suggest different routes when considering safety indices and not just travel time.
Sensibilisation allergénique au cours des huit premières années de vie, facteurs et morbidité associés dans la cohorte de naissances PARIS

Contexte. Les premieres annees de vie apparaissent particulierement propices au developpement de la sensibilisation allergenique. Objectifs. Cette these vise a : i) decrire les profils de sensibilisation allergenique chez le nourrisson et l’enfant, ii) etudier l’association entre ces profils et la morbidite allergique et iii) identifier les facteurs de risque de cette sensibilisation. Methodes. Dans le cadre du suivi de la cohorte prospective de naissances en population generale Pollution and Asthma Risk: an Infant Study (PARIS), la sensibilisation allergenique a ete evaluee chez 1 860 nourrissons a 18 mois et 1 007 enfants a 8/9 ans par dosage des IgE specifiques dirigees contre 16 et 19 allergenes, respectivement. Les informations concernant la sante et le cadre de vie des enfants ont ete recueillies par questionnaires standardises repetes. Des profils de sensibilisation et des profils de morbidite ont ete identifies par classification non supervisee et mis en relation par regression logistique multinomiale. Enfin, les facteurs associes a la sensibilisation allergenique chez le nourrisson ont ete etudies par regression logistique multivariee. Resultats. Des 18 mois, 13,8% des enfants etaient sensibilises et 6,2%, multi-sensibilises. A 8/9 ans, ces prevalences etaient de 34,5% et 19,8%, respectivement. Les profils de sensibilisation identifies chez le nourrisson (3) et dans l’enfance (5) differaient au regard de la morbidite allergique. L’analyse etiologique a permis de preciser le role des expositions precoces aux allergenes et aux microorganismes sur la sensibilisation allergenique. Conclusion. Cette these contribue a une meilleure comprehension de l’histoire naturelle de la sensibilisation allergenique, et ce, des les premieres annees de vie. Cette connaissance est essentielle a la prevention des maladies allergiques qui en decoulent.
Study of the Antioxidant Power of the Waste Oil from Palm Oil Bleaching Clay

Palm oil is one of the most consumed oils, one of whose refining steps is the removal of pigments and other substances using bleaching clay as adsorbent. Worldwide production of this oil was 70 million tons in 2017, requiring 1 t of clay to produce 1000 t of refined oil. The residual bleaching clay, having an oil fraction (12.70%) rich in phenolics, carotenoids and tocopherols, was extracted in this study with ethanol to obtain an antioxidant-rich palm oil bleaching extract (POBE), with the aim of using it as a natural antioxidant source. The POBE antioxidant capacity determined by the DPPH method corresponded to a 20.29% inhibition of radical formation. The POBE was also tested for its potential to enhance oxidative stability of passion fruit, pracaxi and Brazil nut oils used as reference oils, and compared to common synthetic antioxidants (tert-butylhydroquinone and propyl gallate), either separately as controls or in mixtures with them. Besides the increased oxidative stability of these oils induced by the POBE, a positive synergistic effect between it and the synthetic antioxidants was observed. These results taken together suggest that the exploitation of the waste oil from bleaching clay as an additive to improve the oxidative stability of biofuels or lubricating oils is feasible.
Comparison of the Short term Efficacy and Serum Markers between Lobaplatin/Paclitaxel- and Carboplatin/Paclitaxel-based Adjuvant Chemotherapy in Patients with Ovarian Cancer

To compare short-term therapeutic efficacies and related changes of serum markers from 2 chemotherapeutic regimes using lobaplatin or carboplatin in combination with paclitaxel in ovarian cancer patients after cytoreductive surgery. 60 patients were recruited with confirmed ovarian cancer. Patients were equally and randomly divided into 2 groups receiving paclitaxel with lobaplatin or carboplatin, respectively. Follow-up was made 6 months post-treatment. The therapeutic efficacy, serum levels of cancer antigen 125/mucin 16 and human epididymis protein 4 as well as the quality-of-life were assessed before and after treatment. No significant difference in therapeutic efficacy was observed between the groups. The response rates at 1, 3 and 6 months were 76.7 % (23/30), 66.7 % (20/30) and 46.7 % (14/30) in the lobaplatin group and 73.3 % (22/30), 63.3 % (19/30), 36.7 % (11/30) in the carboplatin group, respectively. At the end of the chemotherapy, serum levels of human epididymis protein 4 and cancer antigen 125 in both groups returned to normal. However, patients in the lobaplatin group had significantly higher Human epididymis protein 4 and cancer antigen 125 levels than those in the carboplatin group when examined at 3 or 6 month after chemotherapy (p<0.05). Moreover, at the end of follow-up, the quality-of-life score-C30 of the lobaplatin group was better than that of the carboplatin group with statistical significance (p<0.05). Both lobaplatin and carboplatin exert sufficient antitumor efficacy to be included in the standard platinum/paclitaxel-based chemotherapy against ovarian cancer. Lobaplatin, on the other hand, has demonstrated higher efficacy to control the progress of the disease yet less toxicity to warrant better patient quality-of-life.
The Role of Blood Flow Restriction Training to Mitigate Sarcopenia, Dynapenia, and Enhance Clinical Recovery

Aging is associated with progressive losses of muscle mass (sarcopenia) and strength (dynapenia) leading to reduced functional capacity. Traditional aerobic and resistance exercises are commonly recommended to enhance health and mitigate aging-related performance concerns. Recently, blood flow restriction (BFR) exercise has gained scientific merit as a hybrid aerobic and resistance exercise intervention that may be suitable for application in older adults and following musculoskeletal injury to both mitigate and treat the resulting sarcopenia or dynapenia. Muscle hypertrophy ranging from <1% to 2.6% per week and muscle strength gain ranging from <1% to 5.9% per week have been reported following BFR exercise training when combined with various methods (walking, body weight, elastic bands, and traditional weight training). Further, given the projected increase in orthopedic surgeries in the aging population, the anabolic potential of BFR exercise methodology has gained additional interest the area of clinical rehabilitation following musculoskeletal insult. In particular, older adults recovering from various medical procedures may benefit from BFR exercise in order to regain muscular strength and size during recovery to avoid any additional complications from anabolic resistance, weakness, or disuse. Although care should be taken when selecting BFR exercises over traditional therapy interventions, there is evidence BFR exercise is a suitable intervention to mitigate sarcopenia and dynapenia and enhance muscle strength and mass recovery following various clinical conditions. Further, as BFR exercise provides an additional intervention to improve functional capacity by increasing muscle strength, mass and endurance, it’s utility in mitigating sarcopenia and dynapenia in at risk individuals (ie, frail elderly, postoperative) is becoming more apparent.
The Analysis Of Personal Deixis In The "Kaiwa" Practice Of The Fifth Semester Students Of Japanese Education Program In Unnes

Deixis is used for showing and explaining personal, place, time, and the other grammatical variety, which is connected directly in some circumstances. Deixis and pronoun are so related. Japanese has so much type of personal pronouns such as 私/Watashi and 僕/Boku mean “I” 、貴様/kisama and あなた/anata mean you, あいつ/aitsu こいつ/koitsu mean this or that person, and many more. Nevertheless, it depends on the situation and status of the participant in the dialogue. Some of the 2018/2019 fifth semester students of UNNES had taken the basic linguistic subject. However, they got difficulty with the function of personal deixis. The goal of this paper is to explain the form and the function of personal deixis in kaiwa or Japanese conversation practice of the fifth semester students of the Japanese Education Program in UNNES. This paper is using descriptive and qualitative analysis. This paper uses listening involving and speaking techniques to collect the data. This paper also uses the video of the kaiwa or Japanese Conversation practice of the 2018/2019 fifth semester students of the Japanese Education Program in UNNES. The theory of Levinson is used to analyze the data. Based on data analysis, personal deixis that is used by the students is 俺/ore. It functions to express first personal deixis. The second is君/Kimi. It means “you” that refers to the second speaker. The third is隣の人/tonari no hito, which means the next person, refers to the person outside the dialogue.
Modern Love: You, Me, and Smartphone Makes Three

Abstract Romantic, dyadic relationships arise, in part, from communication, disclosure, and boundaries. Information communication technology (ICT), such as smartphones, has rapidly integrated into our personal lives and affected relationship initiation, maintenance, and dissolution. To this point, models attempting to account for this emerging dynamic center on past theories about relationships. However, counselors and researchers would benefit from understanding contemporary couple dynamics that reflect the ICT-mediated changes to coupling that occurred during the last decade. To address this need, researchers conducted a grounded theory study to explore relationship dynamics, mediated by ICT, based on stories and descriptions provided by 16 participants. Findings showed technology influenced relationships in four domains: access, intimacy, boundaries, and presence.
Effects of using Flunixin Meglumine, Metamizole, and Phenylbutazone on equine kidney functions, urinary mucus, and secretory Immunoglobulin A (IgA) concentrations

Summary : Nonsteroidal anti-inflammatory drugs (NSAIDs) are routinely used in equine practices to manage inflammation, endotoxemia, pain or fever in horses. This study was carried out to investigate the effects of the most commonly used nonsteroidal anti-inflammatory drugs on urinary parameters, mucus and immunoglobulin A (IgA) concentrations in horses. Thirty healthy horses (control group) and 20 horses with indications of using either flunixin meglumine (FM), metamizole or phenylbutazone (PHZ) have been used and assigned to group 1, 2 or 3, respectively. Serum creatinine, blood urea nitrogen and electrolytes, in addition to urinary creatinine (U-Cr), urine urea nitrogen and urinary electrolytes, were measured using an automatic analyser. Fractional excretions (FE) of sodium, chloride, potassium, calcium, magnesium and inorganic phosphate, in addition to urinary protein (U-Pro):U-Cr and urinary gamma glutamyl transferase (U-GGT):U-Cr ratios were calculated. Urinary mucus and IgA concentrations and their ratios to the urinary creatinine were measured. The FEMg was significantly higher in group 3 (P<0.033) than the control group. The U-GGT:U-Cr ratio was also significantly increased in group 3 (P<0.001) compared with the control group. The U-Pro:U-Cr ratio was significantly higher in groups 1 and 2 (P<0.007 and P<0.001, respectively) than in the control group. Phenylbutazone (PHZ) had a significantly increased mucus:U-Cr ratio (P<0.005). Significant incre- ases were observed regarding the IgA:U-Cr ratio in groups 1 (P<0.007) and 2 (P<0.014). In conclusion, long-term use of PHZ has an influence on the renal ascending limb of the loop of Henle, and all these drugs could have effects on the proximal tubules. Phenylbutazone causes an increase in urinary mucus secretion, probably as a protective mechanism against the necrotic effect of PHZ. Parameters such as U-Pro:U-Cr and U-GGT:U-Cr ratios and FEMg are helpful in detecting these renal abnormalities.
Strategically designed marine reserve networks are robust to climate change driven shifts in population connectivity

Marine reserves can be effective conservation and fishery management tools, particularly when their design accounts for spatial population connectivity. Yet climate change is expected to significantly alter larval connectivity of many marine species, questioning whether marine reserves designed today will still be effective in the future. Here we predict how alternative marine reserve designs will affect fishery yields. We apply a range of empirically-grounded scenarios for future larval dispersal to fishery models of seven species currently managed through marine reserves in the nearshore waters in Southern California, USA. We show that networks of reserves optimized for future climate conditions differ substantially from networks designed for today’s conditions. However, the benefits of redesign are modest: a set of reserves designed for current conditions commonly produces outcomes within 10% of the best redesigned network, and far outperforms haphazardly designed networks. Thus, investing in the strategic design of marine reserves networks today may pay dividends even if the networks are not modified to keep up with environmental change.
Hybrid differential evolution with the topographical heuristic

– In this article, we present a new hybrid differential evolution (DE) which employs a topographical heuristic introduced in the early nineties as part of a global optimization method. This heuristic is used to select individuals from the DE population in order to be starting points of instances of the Hooke–Jeeves algorithm. The solutions achieved in this phase are potential candidates for the next generation. The method, called TopoDE, is compared with other stochastic optimization algorithms using challenging benchmark problems. The results obtained are quite promising.
The Significance of the Study of the Brain's Hippocampus for the Progress of Biologically-Inspired Computational Systems

The field of Artificial Intelligence faces unprecedented progress. It is expected that the use of Artificial Intelligence to different sectors of science and economy will be increased. This is also shown by the fact that at the moment, Artificial Intelligence is characterised by popularity which is proven through the constant presentations on the news. This chapter shows how the study of the brain's hippocampus can further progress the field of Artificial Intelligence. The chapter presents indicative examples of the literature that show how the study of the hippocampus can lead to the development of specific applications. It also shows the impact to the development of biologically-inspired systems through the analysis of specific capabilities of the hippocampus. A number of conclusions are drawn in relation to the significance of the study of the brain's hippocampus for the development of new applications.