Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyse moléculaire du myélome : vers de nouvelles perspectives thérapeutiques

Le myelome multiple (MM) est une neoplasie hematopoietique chimiosensible. Si une chimiotherapie intensive associee a une autogreffe de cellules souches hematopoietiques permet de doubler la mediane de survie, la rechute reste cependant ineluctable et ce cancer est incurable a l'heure actuelle. Plusieurs exemples ont montre recemment qu'une connaissance precise de la physiopathologie d'un cancer pouvait conduire a l'elaboration de traitements specifiques. Ces nouveaux traitements anti-cancereux ciblant un sous-groupe de tumeurs caracterisees par une alteration moleculaire commune sont une voie de developpement therapeutique prometteuse. Mon travail de these a consiste a etudier la biologie du MM dans une perspective de ciblage pharmacologique de la cellule plasmocytaire maligne. L'utilisation d'anticorps anti-gp130 agonistes a permis de montrer que l'activation de la signalisation par la chaine gp130 du recepteur de l'interleukine-6 (IL-6) est indispensable a la survie et la proliferation des cellules de MM. En corollaire, l'interruption de cette voie de signalisation par la tyrphostin AG490, inhibiteur de la kinase JAK2, bloque la croissance et induit une apoptose dans les plasmocytes tumoraux. Des membranes comportant les ADNc de 268 genes nous ont permis de rechercher l'expression des genes d'autres cytokines et recepteurs de cytokines pouvant jouer un role dans la physiopathologie du MM. Nous avons mis en evidence dans des lignees de MM une boucle autocrine, cruciale pour la survie du plasmocyte tumoral, qui implique la cytokine HB-EGF et son recepteur ErbB1. Le developpement d'un modele de generation in vitro de plasmocytes normaux purifies a permis ensuite la comparaison du transcriptome de plasmocytes tumoraux avec leur contrepartie normale par des puces a ADN analysant l'expression de 6800 genes differents. De nombreux genes sont differentiellement exprimes entre ces deux populations cellulaires et certains genes surexprimes dans les cellules myelomateuses codent pour des proteines qui sont des cibles therapeutiques potentielles, telles que ABL, CBS, RAR? ou RhoC. La possibilite de comparer pour chaque malade le transcriptome des cellules tumorales par rapport a leur equivalent normal va permettre de progresser rapidement dans la comprehension des mecanismes impliques dans l'emergence du clone tumoral et l'identification de nouvelles cibles therapeutiques. Cette approche pourrait aboutir sur la mise en place d'un traitement « a la carte » du MM base sur l'examen du transcriptome du clone tumoral de chaque patient.
Blind decryption for cloud computing

Cloud computing is a tremendous opportunity for both enterprises and end users. Cloud users can benefit from the possibility of remote processing in order to outsource their data and infrastructure; that is why many companies have chosen to adopt cloud-deployed solutions such as remote databases, mail servers, and connected applications. However, the cloud fails to provide sufficient security measure to preserve the privacy of the data even from the service providers. Therefore, the research community has assigned to this topic the utmost attention by proposing several solutions like blind processing. This latter is based on homomorphic encryption schemes and allows performing operations on encrypted data without decryption. This way it is possible to protect users' privacy even from the cloud provider since we only publish an encrypted form of the sensitive data. But, most of the proposed solutions only deal with the case of a mono-setting environment where one user collaborates with one server, whereby the multi-user topology reveals another kind of issues such as key sharing and concurrent access. In this paper, we propose a blind decryption technique based on homomorphic encryption that allows not only a user but multiple users to manage the same encrypted data without sharing the secret key. The proposed protocol could be utilized to build various kinds of cloud applications which require the collaboration of several users like remote databases, files sharing, and video-on-demand services.
Ultrafast selected-energy x-ray absorption spectroscopy (USEXAS) with a laser-driven x-ray source

A laser driven electron x-ray source (LEXS) emitting tungsten Lα lines has been built based on a high repetition rate, terawatt laser system. The Lα characteristic lines overlap with the absorption edge of Ni near 8333 eV. Using this x-ray source, the x-ray absorption spectra near the absorption edge of different Ni compounds have been measured. We term this new method "ultrafast selected energy x-ray absorption spectroscopy (USEXAS). " It provides an efficient way to study ultrafast reaction dynamics of many metal complexes in solution.
Identification of Promoter Elements Involved in Cell-specific Regulation of Rat Smooth Muscle Myosin Heavy Chain Gene Transcription*

In order to identify cis-acting regulatory elements involved in smooth muscle cell-specific gene regulation, we have cloned a 4.7-kilobase pair fragment of the promoter for the rat smooth muscle myosin heavy chain, a protein expressed in differentiated smooth muscle cells. Sequence analysis of a 1.7-kilobase pair portion of this clone reveals potential binding sites for known transcription factors. A comparison of the primary sequence between the rat and rabbit smooth muscle myosin heavy chain promoters reveals numerous conserved consensus binding sites. Transient transfection analysis of promoter deletion constructs in rat aorta and tracheal smooth muscle cells, L8 myoblast cells, and rat pulmonary aorta endothelial cells suggests that a region of the promoter located between −1,249 and −1,317 base pairs is important for the restriction of gene expression to smooth muscle cells. Electrophoretic mobility shift analysis of a highly conserved region located between −1,317 and −1,085 base pairs reveals specific DNA-protein complexes formed in smooth muscle cell extracts, which can be competed with an oligonucleotide containing a nuclear factor 1 binding site.
An Approach for Improving Coherence Degree between SAR Images

As is well know, the interferometric coherence is a key indicator of the quality of the phase values in interferograms for InSAR processing. In order to assure unwrapping smoothly and generate reliable intereferograms, it is very important to improve the coherence degree between SAR images. By analyzing various decorrelation resources, we proposed an approach for improving coherence degree between SAR images. The experimental results indicate that this approach is feasible and effective.
Modulatable orthogonal sequences and their application to SSMA systems

A set of N-1 orthogonal sequences of period N/sup 2/ is proposed, where N is a natural number. Each orthogonal sequence proposed can be modulated by N complex numbers of absolute value 1, so the modulated sequence is also orthogonal. When N is an odd prime number, the absolute value of the cross-correlation function between any two of the N-1 orthogonal sequences is constant and satisfies the mathematical lower bound. This property of the cross-correlation function is not changed when each of the two orthogonal sequences is modulated by N complex numbers of absolute value 1. Two spread-spectrum multiple-access (SSMA) systems using these sequences are proposed. One system is an asynchronous SSMA system, using the proposed sequences unmodulated. The cochannel interference peak between any two channels in this system realizes the mathematical lower bound for an asynchronous SSMA system using a set of orthogonal sequences. The other system is a synchronous SSMA system without cochannel interference which uses the modulated form of the proposed sequences. >
Observation of Moving Dislocation Kinks and Unpinning.

Atomic resolution electron microscopy has been used to obtain images of moving dislocation kinks on partial dislocations at 600 ±C in silicon. Video difference images are used to obtain direct estimates of kink velocity. Observations of kink delay at obstacles, thought to be oxygen atoms at the dislocation core, yield unpinning energies and parameters of the obstacle theory of kink motion. The kink formation energy is obtained from the distribution of kink pair separations in low-dose images and is compared to the kink migration energy. Unlike metals, kink migration rather than formation controls the velocity of unobstructed dislocations in silicon under these experimental conditions. [S0031-9007(96)01391-9]
Scientific Committee on Emerging and Newly Identified Health Risks SCENIHR Potential health risks of exposure to noise from personal music players and mobile phones including a music playing function

Three independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat. SCENIHR Questions concerning emerging or newly-identified risks and on broad, complex or multidisciplinary issues requiring a comprehensive assessment of risks to consumer safety or public health and related issues not covered by other Community risk-assessment bodies. In particular, the Committee addresses questions related to potential risks associated with interaction of risk factors, synergic effects, cumulative effects, antimicrobial resistance, new technologies such as nanotechnologies, medical devices, tissue engineering, blood products, fertility reduction, cancer of endocrine organs, physical hazards such as noise and electromagnetic fields and methodologies for assessing new risks. The opinions of the Scientific Committees present the views of the independent scientists who are members of the committees. They do not necessarily reflect the views of the European Commission. The opinions are published by the European Commission in their original language only. Health risks from exposure to noise from personal music players 3 ACKNOWLEDGMENTS Members of the working group are acknowledged for their valuable contribution to this opinion. The members of the working group are: SCENIHR members: Health risks from exposure to noise from personal music players 4 ABSTRACT Exposure to excessive noise is a major cause of hearing disorders worldwide. It is attributed to occupational noise. Besides noise at workplaces, which may contribute to 16% of the disabling hearing loss in adults, loud sounds at leisure times may reach excessive levels for instance in discos and personal music players (PMPs). It is estimated that over two decades the numbers of young people with social noise exposure has tripled (to around 19%) since the early 1980s, whilst occupational noise had decreased. The increase in unit sales of portable audio devices including MP3 has been phenomenal in the EU over the last four years. Estimated units sales ranged between 184-246 million for all portable audio devices and between 124-165 million for MP3 players. Noise-induced hearing loss is a function of sound level and duration of exposure. In order to counteract noise-induced hearing loss more effectively, a European directive " Noise at Work Regulations " taking effect starting February 2006, established the minimal security level at the equivalent noise exposure limit to 80 …
Community-based marketing: the challenge of virtual communities

Virtual community is a community that is formed on the Internet. The community is a group of people interacting, sharing and working toward a common goal. While the neighbours can speak in their yards, in the online community members interact through social networks such as Twitter, Facebook and Google. They also participate in forums, groups of e-mail, and even in the sections of the comments in blogs and news articles. The online community is best explained by examining the community of “real life”. Close neighbours not only to communicate but also help each other. They have the tools and bring the mail. They make lunch for sick parents and traded with the children. They also support the common interests for example, collaboration, in order to maintain the common and attractive common areas. Scientific problem. Admitting the fact that, we live in e-commerce age and it plays enormous role on improvement of companies and we accept that virtual community is a valuable part of today’s online business. This creates a question, how to determinate methodology of virtual community? Object of the work. Virtual community concept. Aim of the work is to determine conception of virtual community and community-based marketing. Logical structure of the work. This article presents the theoretical analysis of the overview of definitions of virtual communities, describes the conception and general knowledge about it. Article concludes with conclusions. Methods and techniques. For methodology were used descriptive literature review. A descriptive literature review merely describes the key points of virtual community in our days. Descriptive review concentrates on indicating an explainable design from the current literature.
Écoulements dans les mileux poreux peu perméables saturés et non saturés

Le travail consiste a tester d'une maniere comparative et critique les differentes methodes existantes de mesure de la permeabilite de la plus simple a la plus complexe, leurs reproductibilites, leurs limites et leurs possibilites d'amelioration et de proposer d'autres protocoles experimentaux au laboratoire. L'etude de la permeabilite dans le domaine sature a pour objectif de mettre en evidence, d'une part, le role de la contrainte de confinement sur le coefficient de permeabilite et, d'autre part, l'effet du gradient hydraulique a contrainte de confinement constante sur ce meme coefficient, en utilisant deux techniques de mesure : mesure en regime permanent "essai a charge constante" et mesure en regime transitoire "pulse test". Dans le domaine non sature, l'etude de la permeabilite necessite l'utilisation de techniques de mesures plus complexe. Deux techniques de mesure ont ete testees, mesure dans la colonne d'infiltration et dans les dessiccateurs a solutions salines saturees. Che msu permeabilite
Modélisation multi-échelle des transferts en milieux fracturés : application au site de Äspö (Suède)

Dans le cadre de la problematique de l'enfouissement des dechets nucleaires, la barriere geologique constitue la derniere zone de transfert des radio-elements. Cette barriere pouvant etre fracturee des recherches sont menees pour faire progresser la modelisation des transferts en milieu fracture. La complexite du milieu, les contrastes existant entre les differentes zones et les incertitudes liees aux proprietes physiques rendent cette tâche complexe. De plus, apres fermeture du site, les ecoulements lents dans le milieu favorisent des phenomenes diffusifs dans la roche qui contribuent a augmenter le temps de transit des radio-elements. Dans ce contexte, une approche Smeared Fractures a ete developpee pour un schema en Elements Finis Mixtes Hybrides et implementee dans le code Cast3M. Cette approche permet une representation explicite des fractures principales alors que la fracturation de plus petite echelle est homogeneisee. L'utilisation d'un maillage regulier permet, en outre, d'eviter un maillage explicite couteux. La presence des fractures est prise en compte par un champ heterogene de proprietes. Ces proprietes sont affectees de maniere a respecter les criteres de conservation des flux (hydraulique et massique) a l'echelle de la fracture. Pour l'ecoulement, l'approche Smeared Fractures presente des performances comparables a celles obtenues avec des approches discretes tandis que le caractere 3D de la geometrie des blocs matriciels est respecte lors de la resolution du transport. Le choix des discretisation spatiale et temporelle doit respecter des criteres qui ont ete etablis. Neanmoins, a l'interieur de ces limites, et suivant la precision desiree, l'approche permet de reduire les temps de calcul. Les resultats de validation et de qualification de l'approche appliquee a des geometries 2D et 3D, synthetiques et realistes, sont presentes pour differents jeux de parametres physiques. Des applications de l'approche au site d'Aspo (Suede) cloturent ce travail.
A STUDY ON THE CONSUMERS’ PERCEPTION TOWARDS ORGANIC FOOD PRODUCTS WITH SPECIAL REFERENCE TO KOLLAM CITY

There has been a growing awareness and preference for organic food products around the globe these days. Today, Organic food products are gaining more acceptance and preference over inorganic food products because of the increasing concerns about health and safety. The present study aims to study the consumer’s perception towards the organic food products, the reasons contributing to the purchase of organic food products, problems faced by the consumers of organic food products and their level of satisfaction with the purchase of organic food products. The data was collected from a sample of 31 organic consumers in Kollam City of Kerala with the help of a structured questionnaire. The study found out that the main reason for the purchase of organic food products by the consumers was because they are considered to be safe. High price was the main problem faced by the consumers of organic food products. The study also found out that majority of the consumers are very much satisfied with the purchase of organic food products. The study suggests that proper awareness of the benefits of organic food products must be made to increase the number of organic food products and necessary steps must be taken by the government to increase the production and distribution of organic food products. Certification and labelling of organic food products are also suggested.
Impact of Social Support on Malaria Management by Burundian Community Health Workers

Impact of Social Support on Malaria Management by Burundian Community Health Workers by Bonaventure Bazirutwabo MPH, Institute of Tropical Medicine, Antwerp, 2005 MD, University of Burundi, 1994 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Health Walden University May 2018 Abstract Malaria is the main cause of mortality for children under the age of 5 in Burundi. The access to malaria diagnostics and treatment is hampered not only because of logistical issues, but also due to the lack of qualified human resources and their inequitableMalaria is the main cause of mortality for children under the age of 5 in Burundi. The access to malaria diagnostics and treatment is hampered not only because of logistical issues, but also due to the lack of qualified human resources and their inequitable distribution across the country. To mitigate the lack of human resources for health, the government of Burundi, along with its partners, shifted some tasks to community health workers (CHWs) to cover unmet healthcare needs for selected diseases such as malaria, diarrhea, and pneumonia. The purpose of this study was to determine whether the social support provided to CHWs had an impact on morbidity due to malaria for children under the age of 5. The social networks and social support theoretical framework was used to explore the type of social support received by CHWs and its impact on the number of children treated. The 88 CHWs who participated in this cross sectional survey, were randomly selected from a pool of 719 CHWs who were part of a pilot project that was implemented in the districts of Gahombo, Gashoho, and Mabayi, from 2011 to 2014. The study findings showed mixed results with a positive correlation between the instrumental support received and the number of children under the age of 5 treated. However, a statistically significant correlation was not established between the emotional, informational, and appraisal support received and the number of children under the age of 5 treated. The positive social change implications of the study include providing evidence to build and enhance human resource capacity for improving the health of children living in Burundi, an under-resourced country, through the development of a support package that can be offered to CHWs to help them perform their duties in a more effective way. Impact of Social Support on Malaria Management by Burundian Community Health Workers by Bonaventure Bazirutwabo MPH, Institute of Tropical Medicine, Antwerp, 2005 MD, University of Burundi, 1994 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy
RESTING POSTURES OF ORB-WEAVING ULOBORID SPIDER S (ARANEAE, ULOBORIDAE)

Observations of 22 orb-weaving species of the family Uloboridae show that these spiders assum e one of four basic resting postures as they hang beneath the web's hub . The primitive pattern found in Tangaroa and Octonoba is characterized by all legs being spread and about equally flexed, whereas i n Zosis the protracted first legs grasp the web at nearly the same point . Uloborus species typicall y assume a more cryptic posture characterized by acutely protracted and flexed first legs . Dense setal tufts proximal to the abruptly flexed leg segment provide outline camouflage and conceal the ex tended, shorter second legs which no longer support the body . In contrast, Philoponella species lack leg tufts and assume a compact posture with first legs folded against the sternum and only the las t three pairs of legs grasping the web. The significance of these findings for uloborid classification an d phylogeny is discussed .
Insulin Postconditioning Reduces Infarct Size in the Porcine Heart in a Dose-Dependent Manner

Aim: Insulin and glucose may have opposite effects when used to reduce ischemia–reperfusion injury. When insulin is administered alone, feeding state determines tolerance and further induces metabolic and hormonal changes. Higher insulin doses are needed for similar activation of cardioprotective Akt signaling in the fed compared to the fasted pig heart. Thus, the aim of the study was to investigate the effects of 2 prespecified insulin doses on infarct size, apoptosis, metabolism, and cardiac function in a clinically relevant, randomized large animal model using conventional percutaneous catheter intervention techniques and including different fasting states. Methods and Results: Twenty-seven female pigs were subjected to 40-minute ischemia and 120-minute reperfusion. Pharmacological postconditioning with intracoronary infusions administered over 3 × 30 seconds was performed at immediate reperfusion. Animals were randomly assigned to 3 groups—preexperimental fasting and intracoronary saline (controls), preexperimental fasting and 0.1U of insulin (fasted Ins0.1U ), and preexperimental feeding and 1.0U of insulin (fed Ins1.0U ). A significant reduction in infarct size was demonstrated in the fed Ins1.0U group (P = .047) but not in the fasted Ins0.1U group (P = .531) compared to controls (infarct size normalized to area at risk ± standard deviation: controls 70.2% ± 12.9%, fasted Ins0.1U 65.0% ± 9.4%, and fed Ins1.0U 54.4% ± 7.3%). Infarct limitation was associated with more uncleaved caspase-3 in the area of risk and the infarcted area, lower circulating free fatty acids, and less increase in heart rate during reperfusion. Fed animals had higher levels of glucose, carnitine, potassium, and normetanephrine and higher heart rate at baseline compared to controls. Conclusion: Insulin postconditioning reduced infarct size in the in vivo pig heart, but the beneficial effects were restricted to the highest dose, which is limited by side effects and can only be given to nonfasted animals. The finding challenges successful general use of insulin in the treatment of reperfusion injury in clinical acute myocardial infarction.