Miracle-dz/UniFAR-FTUs huggingface dataset:
NEW MODIFICATIONS OF AN OLD SCAFFOLD: PYRAZOLOQUINOLINONE DERIVATIVES AND ANALOGUES AS ACTIVE COMPOUNDS ON GABA A RECEPTORS

GABAA receptors (GABAARs) are a class of receptors belonging to a superfamily of pentameric ligand-gated ion channels. So far, nineteen genes coding for nineteen different subunits (α1–6, β1–3, γ1–3, δ, ε, θ, π and ρ 1-3) have been identified in mammalian, and even though heteropentameric assembly leads to a huge subtype heterogeneity, it is believed that the most common receptors are composed of two α, two β, and a γ subunit. [1, 2] These receptors are targets of many clinically used compounds such as intravenous and volatile anesthetics or benzodiazepines, which modulate them via an allosteric binding site at the interface between the α+ and the γsubunit. Among the allosteric modulators identified so far, pyrazoloquinolinones (PQs) have been extensively studied in the last decades for their interesting pharmacological properties on GABAA receptors [3]. Over the years, many modifications of the general PQ scaffold have been performed in order to accomplish compounds with better properties in terms of selectivity, potency and detectability. In this work we investigated modification of ring A, B and C of the PQ scaffold. On ring A, many modifications both in terms of position of substituents and dimensions of the ringhave been explored; among them, the introduction of substituents in position R7 resulted in compounds with functional selectivity for α6β3γ2 receptors[4, 5]. On the contrary, modifications on rings B and C are less investigated [6]. Here, we further explored the impact of R7 on activity of PQ derivatives in α6β3γ2, synthesizing a library of compounds differently substituted in position 7. Furthermore, in order to gain more insight on the effect of changes at rings B and C, we used the pharmacophore of the PQ as template to design a new scaffold, in which the size of ring B is reduced and the ring C is open. Herein we describe the synthesis and the biological properties of the resulting indole-derivatives on α1β3 receptors.
Redesign of the milk powder production chain: assessment of innovative technologies

The dairy industry is energy intensive, mainly due to the use of thermal processes. Milk powder production involves many thermal processes, resulting in a high energy consumption. Over the past decades the current production process has been optimized to a large extent. In order to make the next step forward in energy reduction, as well as in environmental impact, it is necessary to redesign the milk powder production chain. Introduction of new technologies will be the key. Membrane distillation is investigated as an alternative to evaporation for the concentration of milk. Furthermore, a closed loop spray drying system is proposed, aiming to reuse the latent and sensible heat of the exhaust air. Optimization of single process units has an influence on up- and downstream process units. Therefore, it is important to take the whole production chain into account. By combining existing and innovative technologies, evaluating them on energy usage, LCA aspects, and economic aspects different processing chains are optimised. The result is an improved milk powder production chain.
Investigating displacement effects as a result of the Sydney, NSW alcohol lockout legislation

Abstract Aims: On 30 January 2014, in efforts to reduce alcohol-related violence, the New South Wales Parliament adopted alcohol lockout legislation targeting a geographically defined area: the Sydney entertainment precinct. This study used qualitative methods to explore with stakeholders of two areas (Kings Cross/Potts Point and Newtown) whether there was any evidence of displacement of alcohol-related problems from inside to outside the lockout zone. Methods: Four focus groups were conducted in mid-2015 with residents and patrons: two in Kings Cross/Potts Point (where the measures were implemented) and two in Newtown (an alternative entertainment precinct exempt from the measures). Each explored experiences pre and post lockouts and any perceived changes in the number of people in the area, level of disorderly conduct, patterns of drug and alcohol consumption, public amenity and public safety. Findings: Stakeholders in Kings Cross/Potts Point reported many improvements since the reforms: including reduced patron numbers, less waste and improved public amenity. However, stakeholders from Newtown reported the opposite: increased patron numbers, reduced public amenity and reduced public safety. Conclusions: This provides tentative evidence that even if the Sydney lockouts have reduced alcohol-related violence there may have been a partial displacement of alcohol-related problems to outside the lockout zone.
The Effectiveness of Hope Therapy Training on Time Horizon in University Students

This research was conducted to determine how hope therapy training effects on time horizon in university students. The research method is semi-experimental of repeated measuring via control group. The community included all the undergraduate students of science and research branch of Islamic Azad university of Tehran who were studying through 1391-1392 academic year. The thirtymember group was selected by using the available sampling method and replaced in two experimental and control groups randomly after completing hope questionnaire. The participants completed two groups of those questionnaires before presenting the independent variable. Then the hope therapeutic interventions were done in the experimental group. After providing treatment (eight sessions, two sessions per week), the questionnaires were administered again to both groups as a post-test to measure the amount of dependent variables change. The results: the covariance analysis results proved that the therapeutic hope training causes the students' time horizon to increase. After running the posttest and two months, follow up tests were conducted. The results of statistical analysis of average test of two correlated groups revealed that how hope therapy effects on time horizon in university students is persistent over time. (P<0/01) Discussion: the study findings showed that the hope therapy strategies deeply affect the increase of time horizon in students and cause opening more bright futures in students' minds and the affection of this training is resistant through the time.
A transgenic model to study the role of oncogenes and tumour suppression genes in T cell lymphoma.

Transgenic mice have previously been used as an effective in vivo model to examine the role of genetic lesions in tumourigenesis. The work presented in this thesis describes a transgenic approach designed to investigate the consequences of deregulated c-myc and loss of the p53 tumour suppressor gene in the pathogenesis of T-cell lymphoma. Transgenic mice positive for both a CD2-myc transgene and homozygous p53 null mutation were generated by crossing these parental strains together. The p5-/-/CD2- myc+, transgenic mice developed highly malignant, clonal T-cell lymphomas with increased frequency and reduced latency compared to either genotype alone. Tumours were detected in young p53-/-/CD2-myc+ mice as early as 27 days of age with clinical manifestation of disease occurring at between 50 and 86 days of age. These studies revealed the potent synergy between deregulated c-myc and p53 loss in T-cell lymphomagenesis. The latency and clonality of p53-/-/CD2-myc+ tumours however, suggested that CD2-myc and p53-/- lesions alone were insufficient for the induction of a malignant phenotype. This interpretation was confirmed by infection of p5347CD2-myc+ neonatal mice with Moloney murine leukaemia virus (MoMuLV) which resulted in a further acceleration of tumour onset. The mechanism of synergy between CD2-myc and p53-/- is unclear but gross examination of malignant tumours demonstrated that the levels of apoptosis in p53-/-/CD2-myc+ lymphomas were not significantly different to parental groups. This suggests that p53-dependent, c-myc mediated apoptosis does not appear to play a major role at this stage of tumour development. Tumourigenesis was not accelerated in animals heterozygous for the p53 null mutation suggesting that loss of both wild type p53 alleles was required for efficient synergy with the CD2-myc transgene. However studies on p53-/-/CD2-myc+ mice implied that loss of the remaining allele could confer a selective advantage on c-myc expressing tumour cells. Loss of the p53 tumour suppressor gene also collaborated with MoMuLV infection in the development of murine T-cell tumours. However the relatively weak synergy between these lesions compared to that observed with p53 loss and deregulated c-myc may be suggestive of a functional overlap between MoMuLV and p53 loss.
HIV/AIDS & Schlaf

Schlafstörungen bei HIV-Infizierten sind in jedem Krankheitsstadium ein häufiges, aber vielfach zu wenig beachtetes Problem. Im Vordergrund stehen Störungen der Schlafkontinuität und der Schlafarchitektur, die insomnische Beschwerden mit teils ausgeprägter Tagesmüdigkeit hervorrufen. Aber auch das Auftreten von schlafbezogenen Atmungsstörungen wird bei HIV-Infizierten unabhängig von den bekannten Risikofaktoren beobachtet, so dass hier ein Zusammenhang zwischen der Erkrankung und der Stabilität der oberen Atemwege zu vermuten ist.
Effect of Self-resilience and Professional Self-concept, Major satisfaction on Nursing Student’s Adjustment to college life

The purpose of this study was to investigate the self-resilience, professional self-concept, and major satisfaction on nursing students' adjustment to college life and to present the basic data to assist in healthy adaption of college life. The study included 310 students from two universities in Gwangju and Jeonnam. A questionnaire survey was conducted on the subjects to determine their self-resilience, professional self-concept, major satisfaction, and adjustment to college life with nursing as a major. The data were collected from 1, April, 2016 to 15, April using self-report, questionnaires and analyzed through descriptive statistics, percentage, mean, standard deviation, t-test, ANOVA, and Pearson correlation coefficient, using SPSS 20.0. As a result, self-esteem, professional self-concept, major satisfaction, and adjustment to college life averaged 3.80 (out of 4), 2.81 (4), 3.86 (5), and 2.75 (5) respectively. In terms of correlations, there was a significant positive correlation between adjustment to college life and self-resilience (r=.404, p<.001) and professional self-concept (r=.404, p<.001) and major satisfaction(r=.455, p<.001) . In addition, self-resilience (β=.252, p<.001) and major satisfaction (β=.309, p<.001) of variance in adjustment to college life and the explanatory power of the model was 27.2%. Based on these results, improvement programs are necessary to help nursing students get adjusted to college life.
On Structural Features, User Social Behavior, and Kinship Discrimination in Communication Social Networks

In the research of social networks, their structural characteristics, user social behaviors, and user relationships are elements that are important to understand social networks, to predict user behaviors, and to manage social networks. In this article, we took as the research object of social networks the mobile communication network, which is closely connected with people’s real lives. We studied the structural characteristics using the complex network analysis methods and derived the laws that exist in the structure of communication social networks. We analyzed users’ social behaviors or social patterns from the perspective of age, gender, social scope, age differences, and time. In addition, we extracted various salient features of user’s calling behavior, and used the XGBoost and logistic regression (LR) fusion method to establish the Kinship-XL model, which is able to improve the performance and speed. Through the experimental verification, the Kinship-XL model can determine whether there is a kinship between users or not.
Glioblastoma radiosensitization by pimozide.

Glioblastoma (GBM) is the most common form of malignant brain tumor corresponding to approximately 20,000 new cases in the US per year (1). While the best available treatment involves surgery followed by the combination of radiotherapy and temozolomide (2), the survival of the vast majority of patients with GBM remains less than 2 years after diagnosis. Accordingly, considerable research has continued into the development of more effective GBM therapy. At the fundamental and preclinical levels such research has focused on developing experimental models that accurately reflect GBM biology, defining the molecules mediating GBM cell survival and treatment resistance and identifying drugs suitable for targeting those molecules within the constraints of CNS physiology. In the recent article by Lee et al . (3), each of these topics has been addressed in an attempt to suggest a novel, more effective GBM treatment strategy.
The use of antibiotic prophylaxis in patients with solid tumours — when and to whom?

Cancer patients treated due to solid tumours are exposed to bacterial, fungal, and viral infections, and the high morbidity connected to them is caused by cancer itself and anticancer therapy. Systemic chemotherapy and local treatment, e.g. surgery and/or radiotherapy, can contribute to infectious complication, which have a negative impact on the efficacy of the treatment and patients’ quality of life. Therefore, there is a need to look for prevention methods, and antibiotics might be one of the options. Since granulocyte colony stimulating factors (G-CSF) appeared, the use of antibiotic prophylaxis was limited to a few indications. In patients with afebrile neutropaenia the use of antimicrobial therapy should be considered only when coexisting risk factors exist. There are also certain situations in cancer therapy when antibiotic prophylaxis could be useful. The presented publication is aimed to identify situations when the treating clinician should consider antibiotic prophylaxis in a patient with a solid tumour.
Effects of Global and Regional Dust Storms on the Martian Hot O Corona and Photochemical Loss

We examine here for the first time the effects of both global and regional dust storms on the formation of the Martian hot O corona and associated photochemical loss of O. Our study is conducted by utilizing our integrated model framework, which couples our Martian hot O corona model with a multifluid magnetohydrodynamic model for Mars for the dusty and clear atmospheric condition cases. We present our results with the most up‐to‐date cross sections for the O(3P)‐CO2 collisions. The main effect of dust storms on the ionosphere is the upward shift of the ionosphere on the dayside, which results in an increase in production of hot O at all altitudes above the ionospheric peak. However, the dust‐induced inflation of the neutral upper atmosphere results in an enhancement in collisional loss of hot O and thus effectively suppresses the hot O density, reducing the global photochemical loss rate by ~28% for the global dust storm scenario. The relative density structure of the hot O corona does not show any significant changes, while its magnitude decreases at all altitudes.
Anomaly detection on in-home activities data based on time interval

The world population of the elderly is expected to have a continuous growth and the number of elderly living in solitude is also expected to increase in the coming years. As our health decline with age, early detection of possible deterioration in health becomes important. Behavioral changes in in-home activities can be used as an indicator of health decline. For example, changes in routine of in-home activities. Past research mainly focused on detecting anomalies in routine of each type of in-home activities individually. In this paper, an anomaly detection model to detect changes in routine of in-home activities collectively for a day is proposed. The experiment was evaluated with an existing public dataset. The experimental results demonstrated that the anomaly detection model performed well on unseen testing data with an accuracy of 94.44%.
Comparative analysis between VIIRS-DNB and DMSP-OLS night-time light data to estimate electric power consumption in Uttar Pradesh, India

ABSTRACT The night-time light (NTL) data from Visible Infrared Imaging Radiometer Suite’s Day/Night Band (VIIRS-DNB) onboard Suomi National Polar-Orbiting Partnership (S-NPP) spacecraft available since April, 2012 have successfully addressed some of the limitations of Defense Meteorological Satellite Program’s Operational Linescan System (DMSP-OLS), owing to improved radiometric and spatial resolutions and onboard calibration. Earlier, DMSP-OLS NTL images majorly contributed for understanding the spatio-temporal dynamics of socio-economic factors such as Gross Domestic Product (GDP) and Electric Power Consumption (EPC), but the problem of saturated pixels and blooming effect affected the correlation with sum of lights (SOL). In the present study, we evaluate different methods to generate the annual VIIRS-DNB NTL composites from available monthly products for estimating EPC at different scales, and compare their performance with DMSP-OLS annual composites. The VIIRS-DNB annual NTL composites are prepared using various statistical measures, seasonal decomposition and principal component analysis (PCA). The SOL derived from these composites were analysed with respect to EPC at Zonal and Electricity Distribution Company (DISCOM) levels in the Uttar Pradesh State of India to identify the most appropriate annual representation of NTL from VIIRS-DNB. It is found that the annual composites prepared using PCA method provide the best results at both Zonal and DISCOM levels. Further, VIIRS-DNB annual NTL composites perform better than the DMSP-OLS composites. At the Zonal level, some of the highly populated and fully electrified Zones exhibit a distinct SOL-EPC relationship, attributable to enhanced power consumption by indoor equipment and industrial activities, which is not captured by satellite. Finally, empirical EPC prediction models are developed based on time-series VIIRS-DNB data from 2013 to 2017, which will help understanding the EPC patterns at regional level in the State of Uttar Pradesh.
A GIS-based Decision-Making Support System for Wind Power Plant Site Selection, Case Study for Saskatchewan

The increasing developments of wind power plants occur in many countries, which are used to mitigate the adverse effects of fossil fuels on the environment. In consideration of negative impacts, wind energy should be systematically analyzed in order to opti-mize the plans of governments and developers. A decision-making support system for wind power plant site selection was developed by using geographical information system in this study. The environmental, economic, and technical factors are invoked to generate the methodology. By comparing the overall performance index from the results, the best locations for wind power plants can be selected. The methodology was applied to the case study of Saskatchewan, where the development of wind power plant could be considered urgent. The results demonstrate that Saskatchewan has great potential for wind power energy development and southwest Saskatchewan is the most favorable area.
Physical Layer Authentication Jointly Utilizing Channel and Phase Noise in MIMO Systems

In this paper, we propose a physical layer authentication scheme in heterogeneous coexist multiple-input-multiple-output (MIMO) systems. This scheme utilizes two physical layer features in terms of location-specific channel gains and transmitter-specific phase noise caused by imperfect oscillators to identify transmitters. Three properties of the proposed scheme: covertness, robustness, and security, are analyzed in detail. By using a maximum-likelihood estimator (MLE) and extended Kalman filter (EKF), we estimate channel gains and phase noise, and formulate variances of estimation errors. We also quantize the temporal variations of channel gains and phase noise through the developed quantizers. Based on quantization results and theories of hypothesis testing and stochastic process, we then derive the closed-form expressions for false alarm and detection probabilities with the consideration of quantization errors. Simulations are carried out to validate the theoretical results of the two probabilities. Based on theoretical models, we further demonstrate that the proposed scheme makes it possible for us to flexibly control authentication performance by adjusting thresholds (for channel gain, phase noise, and decision, respectively) to achieve a required authentication performance in specific MIMO applications.
Current evidence linking nutrition with brain health in ageing

Cognitive dysfunction and depression are significant problems of ageing with major health and socio-economic impacts; therefore, preventing or delaying the onset of these disorders should be a public health priority. In particular, there is a need to identify modifiable factors that could be targeted to promote better brain health in ageing. Epidemiological studies indicate a protective role for certain dietary patterns, in particular the Mediterranean diet, and for specific nutrients, including n-3 polyunsaturated fatty acids, polyphenols and B vitamins. Although, the evidence to date from randomised controlled trials is generally inconsistent, there is clearer evidence to support a role for folate and related B vitamins in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing. Future studies incorporating new technologies offer much promise for the development of effective nutrition strategies that could reduce the risk of cognitive and mental disorders and improve quality of life in our ageing population.
Epilepsy and the Interictal State: Co-morbidities and Quality of Life

Epilepsy care traditionally focuses on seizures, yet for most epilepsy sufferers, other interictal factors such as mood, cognitive abilities, and treatment adverse effects most influence how they feel and function day to day. Epilepsy and the Interictal State is a practical and comprehensive text that covers quality of life issues, cognition and therapy, adverse effects of epilepsy treatments, mood state and psychiatric co-morbidity and general health aspects of epilepsy. Each chapter employs a standard structure providing background, epidemiology, pathophysiology, etiology, diagnosis, treatment, prognosis and further practical advice. From an international team of expert editors and contributors, Epilepsy and the Interictal State is a valuable resource for specialist epileptologists and neurologists, as well as for neurosurgeons, neurology nurses, psychiatrists, family physicians and general practitioners.
The Role of Sugar-sweetened Water in the Progression of Nonalcoholic Fatty Liver Disease

ii Acknowledgments . v Reference Style . vii List of Tables . xii List of Figures . xiii Chapter 1: Introduction . 1 Chapter 2: Review of Literature . 4 2.1 Nonalcoholic Fatty Liver Disease. 4 2.1.