Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Aromatherapy Abdominal Massage using Peppermint Versus Ginger oils on Primary Dysmenorrhea among Adolescent Girls

Primary dysmenorrhea (PD) is one type of painful menstruation. Because of recent concerns about pharmacological therapy, several studies investigated the efficacy of numerous non pharmacological therapy for the relief of dysmenorrhea such as aromatherapy. Aromatherapy is the therapeutic use of essential oils obtained from plants. Currently there is a lack of sound evidence regarding the appropriate use of aromatherapy for menstrual cramps. Therefore, this study aimed to identify the effect of aromatherapy abdominal massage using peppermint versus ginger oils on primary dysmenorrhea among adolescent girls. Setting: The study was conducted at the Faculty of Nursing, Alexandria University in Egypt. The sample comprised a 120 eligible nursing students who were suffering of moderate to severe primary dysmenorrhea. They were randomly assigned equally into 3 groups: study group (1) had received aromatherapy massage by peppermint oil. Study group (2) had received aromatherapy massage by ginger oil. Control group (3) had received massage by almond oil. Each subjects in the three groups received 15 minutes of aromatherapy, once daily for five consecutive days prior to menstruation for two successive cycles using a randomized control clinical trial study design. Three tools were validated and used for data collection; basic data and menstrual history interview schedule, Visual Analogue pain intensity Scale (VAS)and Menstrual symptom questionnaire (MSQ). Results: The main study findings show that, before intervention there was no statistically significant difference between the study and control groups regarding the severity of primery dysmenorrhea and its associated symptoms. Yet, students who received aromatherapy massage with either peppermint or ginger oils showed significantly reduction on the severity of dysmenorrhea and its location as well as daily life activities than control group, one and two months after intervention. Duration of pain, anorexia, diarrhea and/or constipation and level of mood were significantly improved among study group who received aromatherapy massage with peppermint oil. On the other hand nausea /vomiting, dizziness/ fatigue and headache were significantly improved among study group who received aromatherapy massage with ginger oil than the other two groups. The study Concluded that aromatherapy by either peppermint or ginger oils is effective in alleviating menstrual pain and its location. Peppermint is effective in improving the duration of pain, anorexia, diarrhea and/or constipation and level of mood. While ginger is effective in relieving nausea /vomiting, dizziness/ fatigue and headache. (Sahar Anwar Rizk. Effect of Aromatherapy Abdominal Massage using Peppermint Versus Ginger on primary
Insitu reduction of charge noise in GaAs/AlxGa1-xAs Schottky-gated devices.

We show that an insulated electrostatic gate can be used to strongly suppress ubiquitous background charge noise in Schottky-gated GaAs/AlGaAs devices. Via a 2D self-consistent simulation of the conduction band profile we show that this observation can be explained by reduced leakage of electrons from the Schottky gates into the semiconductor through the Schottky barrier, consistent with the effect of "bias cooling. " Upon noise reduction, the noise power spectrum generally changes from Lorentzian to 1/f type. By comparing wafers with different Al content, we exclude that DX centers play a dominant role in the charge noise.
Increased gelsolin expression and retarded collagen lattice contraction with smooth muscle cells from Crohn's diseased intestine

Intestinal smooth muscle cells (SMC) produce the fibrotic tissue, strictures, that characterize Crohn's disease. These SMC change their phenotype from a contractile muscle form to an inflammation‐responsive form that migrates and synthesizes a collagen matrix. It is postulated that the inflammatory responsive SMC form associates differently with its surrounding collagen matrix compared to the normal SMC form. SMC derived from Crohn's diseased and uninvolved bowel were sustained in cell culture. Cultured SMC incorporated in collagen lattices have the capacity to reduce the size of that lattice, referred to as lattice contraction. At day 2, Crohn's SMC‐populated collagen lattices were reduced to 21% of their initial area, while non‐Crohn's SMC collagen lattices were reduced to 8%. Crohn's SMC demonstrate retarded lattice contraction compared to non‐Crohn's SMC. When grown in monolayer culture, Crohn's‐derived SMC cover 30% more area than non‐Crohn's SMC. By Western blot analysis Crohn's SMC express more gelsolin, an actin‐binding protein found elevated in cells exhibiting increased cell motility. Was the increased expression of gelsolin related to retarded collagen lattice contraction? Intracellular levels of gelsolin were elevated by the electroporation of plasma gelsolin protein into suspended non‐Crohn's SMC. When incorporated in collagen lattices, gelsolin loaded cells showed retarded lattice contraction compared to SMC loaded with albumin. Crohn's SMC show increased expression of gelsolin, which may be associated with a diminished capacity to reorganize collagen fiber bundles. It is suggested that increased concentrations of gelsolin in Crohn's SMC is consistent with enhanced cell migration as a consequence of the inflammatory state of Crohn's diseased intestine. J. Cell. Physiol. 182:303–309, 2000. © 2000 Wiley‐Liss, Inc.
Membrane permeability change during inhibitory transmitter action in crustacean muscle

Impulses in the inhibitory nerve fibre to the limb muscle of the crustacean have been shown to increase the conductance of the post-junctional muscle fibre membrane without there being, in the absence of an applied current, an appreciable change in membrane potential from the resting level (Fatt & Katz, 1953 b). This increase in membrane conductance may be taken to indicate an increase in membrane permeability toward some ions in the neighbourhood, and the fact that the equilibrium potential at which there is no net transfer of charge is close to the resting potential suggests that the ions involved are potassium or chloride, both of which will probably be in a condition of equilibrium across the resting membrane. The experiments reported in this paper were designed to establish toward which of these two species of ions the permeability is increased. The procedure was to examine the effect on the inhibitory response of variation in the concentrations of K+ and Clions in the solution bathing the muscle. A subsidiary problem was to determine the action of y-aminobutyric acid on the membrane properties.
Importance of eIF2α phosphorylation as a protective mechanism against heat stress in mouse male germ cells

Mammalian male germ cells are exceptionally labile to heat stress. A temporal arrest of translation is one immediate response to heat, which involves heat‐induced phosphorylation of eukaryotic initiation factor 2α (eIF2α) to block the formation of the translational initiation complex. Here, we investigated the protective mechanisms against heat stress in mouse male germ cells. All known eIF2α kinases were expressed in lineage‐ and developmental stage‐specific manners in the testis; noteworthy was the presence of Gcn2 (General control nonderepressible 2 kinase) in spermatocytes of all seminiferous tubules. Multiple eIF2α kinases are likely activated upon heat stress in male germ cells. ISRIB (Integrated stress response inhibitor) was then used to determine the events downstream of eIF2α phosphorylation. ISRIB significantly reduced the rate of stress granule formation in spermatocytes at early‐stage (III‐IV) seminiferous tubules, and induced a number of apoptotic germ cells at late‐stage (XI‐XII) seminiferous tubules near the onset of meiosis. Thus, stress granule formation is a downstream event of eIF2α phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages. Mol. Reprod. Dev. 84: 265–274, 2017. © 2017 Wiley Periodicals, Inc.
Mutual Human Actuation

Human actuation is the idea of using people to provide large-scale force feedback to users. The Haptic Turk system, for example, used four human actuators to lift and push a virtual reality user; TurkDeck used ten human actuators to place and animate props for a single user. While the experience of human actuators was decent, it was still inferior to the experience these people could have had, had they participated as a user. In this paper, we address this issue by making everyone a user. We introduce mutual human actuation, a version of human actuation that works without dedicated human actuators. The key idea is to run pairs of users at the same time and have them provide human actuation to each other. Our system, Mutual Turk, achieves this by (1) offering shared props through which users can exchange forces while obscuring the fact that there is a human on the other side, and (2) synchronizing the two users' timelines such that their way of manipulating the shared props is consistent across both virtual worlds. We demonstrate mutual human actuation with an example experience in which users pilot kites though storms, tug fish out of ponds, are pummeled by hail, battle monsters, hop across chasms, push loaded carts, and ride in moving vehicles.
Whole-exome sequencing reveals potential molecular predictors of relapse after discontinuation of the targeted therapy in chronic myeloid leukemia patients

Abstract Chronic myeloid leukemia (CML) is a myeloproliferative disease well treated by tyrosine kinase inhibitors (TKIs). The aim was to identify genes with a predictive value for relapse-free survival after TKI cessation in CML patients. We performed whole-exome sequencing of DNA from six CML patients in long-lasting deep molecular remission. Patients were divided into two groups with relapse (n = 3) and without relapse (n = 3) after TKI discontinuation. We found variants in genes CYP1B1, ALPK2, and IRF1 in group of patients with relapse and one variant in gene PARP9 in group of patients without relapse. We verified prognostic value of the found markers in a small group of patients with TKI discontinuation and demonstrated their high sensitivity (77%), specificity (86%), positive (85%), and negative (79%) predictive values. Thus we revealed genetic variants, which are potential markers of outcome prediction in CML patients after TKI discontinuation.
Extreme Scale Multi-Physics Simulations of the Tsunamigenic 2004 Sumatra Megathrust Earthquake

We present a high-resolution simulation of the 2004 Sumatra-Andaman earthquake, including non-linear frictional failure on a megathrust-splay fault system. Our method exploits unstructured meshes capturing the complicated geometries in subduction zones that are crucial to understand large earthquakes and tsunami generation. These up-to-date largest and longest dynamic rupture simulations enable analysis of dynamic source effects on the seafloor displacements. To tackle the extreme size of this scenario an end-to-end optimization of the simulation code SeisSol was necessary. We implemented a new cache-aware wave propagation scheme and optimized the dynamic rupture kernels using code generation. We established a novel clustered local-time-stepping scheme for dynamic rupture. In total, we achieved a speed-up of 13.6 compared to the previous implementation. For the Sumatra scenario with 221 million elements this reduced the time-to-solution to 13.9 hours on 86,016 Haswell cores. Furthermore, we used asynchronous output to overlap I/O and compute time. CCS CONCEPTS • Applied computing → Earth and atmospheric sciences;
Reducing hardware requirement in FIR filter design

A hardware optimization scheme based upon minimum-adder CSD multiplier blocks is combined with a technique for trading adders for delays to reduce hardware requirements for fixed-coefficient FIR filters well below that achieved with either technique alone. The technique starts with determining the minimum order filter necessary to meet the filter specifications assuming infinite precision filter coefficients. Then the coefficients are truncated to B bits (which may be specified by the designer) and the order of the filter is increased, if necessary, to meet the filter specifications. From this baseline filter, an exhaustive search is carried out by increasing the filter order (adding delays) and decreasing the bits (decreasing adders) to search for the minimum hardware. At each search point, the minimum-adder CSD multiplier block approach is used to assure the optimum hardware realization. The result is the implementation in FPGAs or VLSI of FIR filters with less real estate and/or with less power consumption.
Mechanistic and Kinetic Studies of the Photodegradation of Benz[a]anthracene in the Presence of Methoxyphenols.

Kinetic studies were employed to assess an empirical rate law describing the rate of photodegradation of polycyclic aromatic hydrocarbons (PAH) in the presence of substituted methoxyphenols. A solution of benz[a]anthracene (BaA) and vanillin in toluene was chosen as the model system. Further experiments using structure activity relationships were applied to the model system to investigate the mechanism for BaA photodegradation. Data from these experiments suggest that the rate-determining step in the mechanism is hydrogen abstraction of the phenolic hydrogen from vanillin
Usefulness of Prezi and PowerPoint presentation

In everyday teaching practice great helping to the clearness and visualization of the content are presentations. Two decades ago, the blackboard notes were replaced with traditional slides and overhead projector. With the availability of computer hardware and software are traditional slides converted to electronic slides. In our area the most frequently are used PowerPoint slides, but the problem is payable package of the Microsoft Office'. Users looking for free of charge and useful presentation programs. For teachers and students is Prezi a free online presentation service provider, where the applicability in four years grow up to more than 500 million users. The article presents the results of the usefulness of PowerPoint and Prezi presentations among university biology students. They mostly use the PowerPoint presentations because generally they do not know Prezi presentations. Students also expressed the advantages and disadvantages of one and the other presentation program.
Optically-remoted probes for airborne RF sensors

We detail new concepts of optically-remoted probes that can be applied to sense and calibrate RF systems used in airborne domain. The proposed sensors produce minimal perturbation on the probed electromagnetic fields since they are built from non-metallic material (expect for the tiny integrated antenna element). The inherent low sensitivity and cross-talk to electromagnetic waves of fibre-based transmissions allow the introduction of these probes in the vicinity of the radiating antennas. These approaches lead to significant improvements since they will enable the calibration of the full RF system (starting from its radiating elements up to the RF processing unit), while they can operate not only during integration phases but also during operations.
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy.
Sciatic neuropathy caused by an intermuscular lipoma in dogs

Lipomas are common, usually slow-growing, benign tumours of mesenchymal origin that most commonly occur on the proximal limb and trunk of middle-aged to older dogs. They are rarely associated with either local invasion or malignancy, unlike infiltrative lipomas and liposarcomas, respectively. Three dogs, a 10-year-old mixed-breed female of 35 kg body weight, a 10-yearold mixed-breed male of 30 kg body weight, and an 11-year old female German shepherd of 38 kg body weight, were presented with a 3–6 month (median, 5 months) history of progressive left pelvic limb lameness and thigh swelling. A lesion affecting the soft tissue of the thigh and the left sciatic nerve was suspected in all dogs. A left thigh magnetic resonance (MR) revealed a homogenous, well circumscribed tumour in the mixed-breed dogs and two similar tumours in the German shepherd. The tumours were interposed between the semimembranosus and semitendinosus muscles. The treatment involved surgical extirpation of the tumours. A follow-up examination 12 months post operation showed mild lameness and proprioceptive deficits in the operated limb in all the dogs. The withdrawal reflex and the cranial tibial reflex were normal. Neither mass nor thickening were palpable in the thigh region. Although intermuscular lipoma is rare, it should be suspected in dogs with progressive monoparesis. Magnetic resonance is a valuable imaging method for diagnostic precision and pre-operative planning. Quick diagnosis and decompressive surgery are required to allow recovery. Canine, benign tumour, sciatic nerve
Brain Responses to Changes in Speech Sound Durations Differ Between Infants With and Without Familial Risk for Dyslexia

A specific learning disability, developmental dyslexia, is a language-based disorder that is shown to be strongly familial. Therefore, infants born to families with a history of the disorder are at an elevated risk for the disorder. However, little is known of the potential early markers of dyslexia. Here we report differences between 6-month-old infants with and without high risk of familial dyslexia in brain electrical activation generated by changes in the temporal structure of speech sounds, a critical cueing feature in speech. We measured event-related brain responses to consonant duration changes embedded in ata pseudowords applying an oddball paradigm, in which pseudoword tokens with varying /t/ duration were presented as frequent standard (80%) or as rare deviant stimuli (each 10%) with an interval of 610 msec between the stimuli. The infants at risk differ from control infants in both their initial responsiveness to sounds per se and in their change-detection responses dependent on the stimulus context. These results show that infants at risk due to a familial background of reading problems process auditory temporal cues of speech sounds differently from infants without such a risk even before they learn to speak.
Changes in egg quality traits during the last phase of production: is there potential for an extended laying cycle?

Abstract 1. A field study was conducted to investigate the deterioration of eggshell quality at the end of lay and examine the potential to extend the production cycle. A total of 1200 eggs were assessed originating from commercial farms in Belgium: eggs were random sampled at the collection belt at 57–65 weeks of age and at the end of the production cycle (74–92 weeks). 2. Based on a linear mixed model, egg quality was estimated for an average flock at 60 weeks of age and changes in quality traits were predicted until the end of the laying cycle. 3. Egg weight increased by 0.07 g every week from 60 weeks of age onwards and shape index decreased by 0.04 unit weekly (P < 0.001). Haugh unit values decreased weekly by 0.38 units whereas relative yolk weight was unaffected after 60 weeks of age. Relative albumen weight showed a weekly increase of 0.02% and relative shell decreased by 0.02% weekly until the end of lay. 4. Shell quality traits were also influenced by age: shell index decreased by 0.013 g weekly, shell thickness was calculated to be 0.23 µm thinner every week, deformation increased by 0.06 µm weekly from 60 weeks to the end of the laying cycle. Variability of the deformation of eggs indicated more heterogeneous shell quality at the end of the production cycle. Dynamic stiffness increased from 60 weeks of age on. 5. Laying hens were depopulated on average at 80 weeks of age (varying from 74–92 weeks). Although ageing had a significant effect on most of the egg quality traits, egg quality was still acceptable at the end of lay, indicating the potential to extend the laying cycle.
Intensive replacement of basal insulin in patients with type 1 diabetes given rapid-acting insulin analog at mealtime: a 3-month comparison between administration of NPH insulin four times daily and glargine insulin at dinner or bedtime.

OBJECTIVE To establish differences in blood glucose between different regimens of optimized basal insulin substitution in type 1 diabetic patients given lispro insulin at meals, i.e., NPH injected four times a day versus glargine insulin once daily at dinner or at bedtime. RESEARCH DESIGN AND METHODS A total of 51 patients with type 1 diabetes on intensive therapy (NPH four times/day and lispro insulin at each meal) were randomized to three different regimens of basal insulin substitution while continuing lispro insulin at meals: continuation of NPH four times/day (n = 17), once daily glargine at dinnertime (n = 17), and once daily glargine at bedtime (n = 17) for 3 months. Blood glucose targets were fasting, preprandial, and bedtime concentrations at 6.4-7.2 mmol/l and 2 h after meals at 8.0-9.2 mmol/l. The primary end point was HbA(1c). RESULTS Mean daily blood glucose was lower with dinnertime glargine (7.5 +/- 0.2 mmol/l) or bedtime glargine (7.4 +/- 0.2 mmol/l) versus NPH (8.3 +/- 0.2 mmol/l) (P < 0.05). A greater percentage of blood glucose values were at the target value with glargine at dinner and bedtime versus those with NPH (P < 0.05). HbA(1c) at 3 months did not change with NPH but decreased with glargine at dinnertime (from 6.8 +/- 0.2 to 6.4 +/- 0.1%) and glargine at bedtime (from 7.0 +/- 0.2 to 6.6 +/- 0.1%) (P < 0.04 vs. NPH). Total daily insulin doses were similar with the three treatments, but with glargine there was an increase in basal and a decrease in mealtime insulin requirements (P < 0.05). Frequency of mild hypoglycemia (self-assisted episodes, blood glucose < or =4.0 mmol/l) was lower with glargine (dinnertime 8.1 +/- 0.8 mmol/l, bedtime 7.7 +/- 0.9 mmol/l) than with NPH (12.2 +/- 1.3 mmol/l) (episodes/patient-month, P < 0.04). In-hospital profiles confirmed outpatient blood glucose data and indicated more steady plasma insulin concentrations at night and before meals with glargine versus NPH (P < 0.05). There were no differences between glargine given at dinnertime and at bedtime. CONCLUSIONS Regimens of basal insulin with either NPH four times/day or glargine once/day in type 1 diabetic patients both result in good glycemic control. However, the simpler glargine regimen decreases the HbA(1c) level and frequency of hypoglycemia versus NPH. In contrast to NPH, which should be given at bedtime, insulin glargine can be administered at dinnertime without deteriorating blood glucose control.