Miracle-dz/UniFAR-FTUs huggingface dataset:
Demoralization and Its Relationship with Depression and Hopelessness in Suicidal Patients Attending an Emergency Department

Emergency departments (EDs) play an increasingly crucial role in the management of patients with suicidal behavior (SB). Demoralization has been associated with SB in various populations and conditions, but little is known about the effect of this construct in SB patients who attend an ED. Therefore, a more inclusive SB assessment which considers the demoralization construct could be useful in clinical practice. The main aim of this study was to assess the presence and severity of demoralization in patients visiting EDs for SB. Secondly, the maintenance of the relationship between demoralization and SB after controlling for depression and the proportion of variance which accounted for hopelessness was investigated. A cross-sectional study of patients (N = 199) visiting an ED for SB was performed, which examined the role of demoralization, hopelessness, and depression on suicidal ideation (SI) and suicide attempts (SAs). Demoralization was strongly and positively correlated with SI. Demoralization was related to major depressive episodes, but it was confirmed to be a different and, probably, more sensitive construct for SB, validating its specificity in relation to depression. Hopelessness accounted for a small portion of the variance in SI, compared to demoralization. Formal support for the association of demoralization with SI was provided. Demoralization can improve SB assessment in EDs, particularly among patients whose suicide risk can be unnoticed. Furthermore, demoralization represents a clinically useful concept to increase comprehension of the suffering of the suicidal patient and a possible target for psychotherapeutic interventions.
IMPROVED ARTIFICIAL BEE COLONY(iABC)- WLAV TECHNIQUE IN POWER SYSTEM STATE ESTIMATION (iABC)-Weighted least absolute value Compared with Particle Swarm Optimization Technique

: The data of electrical network is normally at the control center and it uses certain protocols , the measured data have some uncertainties due the meter and communication error (noise) . The aim of state estimation of state variables of power system by minimization the measurement error (noise) present at control center In this paper we discusses the application of an, improved Artificial Bee colony algorithm optimization (improved ABC)- weighted least absolute value method and its effectiveness over other AI optimization algorithm, Particle swarm optimization (PSO), is shown by comparing both the solution. The true state variable values obtained by using Newton-Raphson (NR) algorithm.
( Update for PR 1206-110 ) Measurement of Neutron Spin Asymmetry A n 1 in the Valence Quark Region Using an 11 GeV Beam and a Polarized 3 He Target in Hall C July 1 , 2010

We present here an update to PR12-06-110 , precision measurements of the neutron spin asymmetry An1 in the kinematic region 0.3 < x < 0.77 and 3 < Q 2 < 10 (GeV/c). The proposed measurement will be performed in Hall C using the upgraded 11 GeV beam, the HMS and the Super HMS (SHMS) spectrometers, and a polarized He target. After updating on the recent theoretical development in section 1, we will present experimental updates: We plan to use the same target and cell design as the approved GEN-II experiment which has a factor of 8 improvement on the target luminosity compared to our original proposal. As a result, we are able to reduce the beam time request for DIS measurements by about 50% while matching approximately the statistical uncertainty of An1 at the highest x point (x = 0.77) to its systematic uncertainty, thus maximizing the physics outcome. Updated rate estimations are presented in section 2.3. In addition, in this update we have added two kinematic settings for measurements of An1 in the resonance region for radiative corrections, which will require 2 days of beam time and the results can be compared with DIS measurements to test the quark-hadron duality of polarized structure functions to higher precision than existing data. The procedure of DIS data analysis and systematic uncertainties remain the same as the original proposal and will be briefly repeated in section 3, along with systematic uncertainties of the resonance measurement. The proposed measurements will provide the first precision data on A1 in the valence quark region above x = 0.61. If combined with existing world proton data and projected proton data from CLAS12, it will provide precision results on the polarized to unpolarized PDF ratios ∆u/u and ∆d/d. These results will test various predictions including those from the relativistic constituent quark model, leading-order perturbative QCD (pQCD), and the latest pQCD calculations including the quark orbital angular momentum. The wide Q span of the measurement will explore Q-dependence of An1 and improve our knowledge on the higher-twist effects. In sections 4.1 and 4.2 we present updates on the projected A1 results. While in section 4.3 of the original proposal we described the complementarity to the approved Hall A 11 GeV An1 experiment E12-06-122 using the BigBite spectrometer, in section 4.3 of this update we will specifically address the condition raised by PAC30. In section 4.4 we will provide projected ∆q/q results when the proposed DIS measurements are combined with the future CLAS12 proton experiment. The updated beam time request will be presented at the end in section 5. The original proposal from PAC30 will be submitted along with this update as the supporting document.
Oxytocin and the stress buffering effect of social company: a genetic study in daily life

Abstract Social relationships are a crucial determinant of both mental and physical health. This effect is partly due to social buffering of stress. Animal studies suggest that social buffering is mediated via the oxytocin system, while studies in humans are sparse and limited by the low ecological validity of laboratory settings. In the present study, participants (N = 326) completed smartphone questionnaires four times a day over 4 to 5 days, measuring stressors, negative affect, and social context to assess social buffering. We found that under stress, participants reported a higher need for social company. Further, the impact of prior stressful events on momentary negative affect was attenuated by the perceived pleasantness of current social company. This social buffering effect was moderated by haplotypes of the oxytocin receptor gene, based on two well-described single nucleotide polymorphisms (rs2268498, rs53576). Effects were robust when controlling for gender and age, applying different data quality criteria, and even apparent in genotype-based analyses. Our findings demonstrate that social buffering and its modulation by oxytocin system characteristics have implications for life as lived outside the laboratory.
Observations on radiological correction of acetabular dysplasia by Dega transiliac osteotomy

Background: Several osteotomies have been described for the correction of acetabular dysplasia associated with variable outcomes. The purpose of our study was to evaluate the effect of Dega transiliac osteotomy in radiological correction of acetabular dysplasia by assessing the change in various radiological parameters from preoperative period to postoperative period and at a follow up of two years. Methods: This was a prospective observational study conducted on 35 patients of either sex, in the age range of 18 months to 8 years, presenting to the paediatric orthopaedic OPD, of Artemis Health Institute, Gurgaon, Haryana, India between January 2012 and September 2014 in whom a diagnosis of acetabular dysplasia was made. All the patients underwent Dega transiliac osteotomy and the effectiveness of this osteotomy in the correction of acetabular dysplasia was assessed by measuring various radiological parameters preoperatively, postoperatively, and at a follow up of two years. The various radiological parameters included acetabular index (AI), centre edge angle of wiberg (CEAW), reimer’s extrusion index (REI) and the shenton’s line (SL). Results: In present study sample of 35 cases, 29 had DDH, 4 were secondary to cerebral palsy and 2 had developed dysplasia following septic arthritis of the hip. The sex distribution showed 19 females and 16 male patients. All the patients underwent Dega transiliac osteotomy at a mean age of 42.94±21.68 months. The mean value of AI improved from 42.43±4.77 degrees in preoperative period to 19.86±2.45 degrees at follow up. The mean value of CEAW improved from - 32.49±21.60 degrees in preoperative period to 32.06±5.48 degrees at follow up. The mean value of REI, improved from 91.06±21.43 % in preoperative period to 0.29±1.18 % at follow up. The SL was broken in all the 35 patients preoperatively, while at follow up it was continuous in all the patients. These changes in all the four parameters were statistically highly significant (p value<0.001). Conclusions: Thus results of present study demonstrate that Dega osteotomy is a safe, effective and versatile surgical procedure for the treatment of acetabular dysplasia secondary to DDH and other disorders. Since the majority of the patients included in this study had the diagnosis of DDH, the results of this study are more representative of dysplasia associated with DDH.
ANTIOXIDANT POTENTIAL OF ROSELLINIA SANCTAE CRUCIANA SP- ENDOPHYTIC FUNGI ISOLATED FROM AZADIRACHTA INDICA

Endophytic fungi are rich sources of bioactive compounds. We focused to isolate endophytic fungus from Azadirachta indica and to study its antioxidant potential. The antioxidant activities were done by total antioxidant, DPPH free radical scavenging assay and FRAP Assay. Quantification of antioxidant compounds were done by total phenolics and total flavonoids assay. Further the isolated fungus was determined for presence of various phytochemicals. We isolated 20 endophytic fungi from 150 leaf segments on PDA. It was observed that among all fungi maximum activity was shown by PD 17 in Wickerham media (1.915) and minimum by PD 10 in MEB (0.114) at 35 day of incubation. It was observed that maximum inhibition was in PD 17 (65%) in solvent of chloroform and methanol (6:3). Further this endophytic fungus showed presence of all phytochemicals like alkaloids, tannins, flavonoids, saponins, phenolics and terepenoids. Maximum activity was observed at300 μg/ml (4.840) and in DPPH its IC 50 was found to be 71. 2μg/ml while IC 50 values of ascorbic acid (Vitamin C) were found to be 26. 6μg/ml. We observed that amount of the sample (1 mg/ml) which reduced the ferrous ion was found to be 220 equivalent to ascorbic acid μm/l/g. Total phenolics and flavonoids were found to be 38mg/gdw and 1.1 mg/gdw respectively. Molecular identification of endophytic fungus was confirmed using 18S rRNA sequencing using ITS1 and ITS-4 primers. Based on BLAST search of ribosomal RNA gene sequence, the endophytic fungus was found to be closest homolog of Rosellinia sanctae – cruciana having accession number KY307868.
Review of Speech Recognition System

-This paper takes a tour of speech recognition system which includes it’s evaluation and accuracy of system and discuss the structure of utterance that uses the vocal tract to make the utterance. Dynamic warping with its neural approach to convert the speech into text. This paper also explains the basic working of speech recognition system with elaboration of it’s techniques.
Saliva as a diagnostic tool for dental caries, periodontal disease and cancer: is there a need for more biomarkers?

ABSTRACT Introduction: A biomarker is a biological indicator of normal or pathogenic processes. Identification of biomarkers is useful for the prevention, diagnosis and prognosis of diseases as well as for monitoring the progression of pathological disorders. Several types of molecules present in biological fluids can act as biomarkers such as DNA, coding and non-coding RNA, lipids, metabolites, proteins and even microbes. In this context, saliva emerges as a useful diagnostic tool for the detection of biomarkers involved with oral and systemic diseases, since it reflects the pathophysiological conditions of the organism and allows early, rapid, practical and noninvasive detection of biomarkers. Areas covered: This review discusses the properties of saliva as a diagnostic tool and addresses the main identified biomarkers related to dental caries, periodontal disease, head and neck cancer and other types of cancer of considerable incidence among the world population. Expert commentary: Despite extensive efforts which have been directed toward the identification of one or a combination of biomarkers with good predictive values for the early detection of dental caries, periodontal disease and cancer, these biomarkers still need validation before chairside point-of-care devices can be widely used in the clinic.
INFLUENCE OF CHITIN ON POPULATION DYNAMICS AND CHITINASE ACTIVITY OF ANTAGONISTIC BACTERIA

The effect of chitin on population and chitinase activity of antagonistic bacteria were studied under in vitro condition. P. fluorescens (BIB2) and B. subtilis (BIL8) strains in the presence of chitin in liquid medium increased the population of bacterial antagonists. The highest level of bacterial population (200.33 × 10 cfu mlof broth) was observed in chitin containing medium inoculated with P. fluorescens (BIB2) strain. Whereas, chitin containing medium inoculated with B. subtilis (BIL8) strain recorded the bacterial population of 141.33 × 10 cfu mlof broth. Chitin amendment significantly increased the chitinase activity of both the antagonistic bacterial strains. Of these, P. fluorescens (BIB2) responded well to the addition of chitin and produced highest amount of chitinase (7.39 nmol of GlcNAc min ml) in chitin amended medium. Whereas, B. subtilis (BIL8) strain produced 3.92 nmol of GlcNAc min ml of chitinase in chitin amended medium. P. fluorescens (BIB2) + chitin was found to be superior in supporting the survival of P. fluorescens and recorded a population load of 17.00 ×10 cfu gof product at 150 days after storage in talc based formulations. Further the population of P. fluorescens (BIB2) slightly increased from 41.00 ×10 cfu gof product to 45.33 ×10 cfu gof bioformulation at 100 days after storage.
Stroke prevention and control system in China: CSPPC-Stroke Program

In China, stroke is a major cause of mortality, and long-term physical and cognitive impairment. To meet this challenge, the Ministry of Health China Stroke Prevention Project Committee (CSPPC) was established in April 2011. This committee actively promotes stroke prevention and control in China. With government financial support of 838.4 million CNY, 8.352 million people from 536 screening points in 31 provinces have received stroke screening and follow-up over the last seven years (2012–2018). In 2016, the CSPPC issued a plan to establish stroke centers. To shorten the pre-hospital period, the CSPPC established a stroke center network, stroke map, and stroke “Green Channel” to create three 1-h gold rescue circles, abbreviated as “1-1-1” (onset to call time <1 h; pre-hospital transfer time < 1 h, and door-to-needle time < 1 h). From 2017 to 2018, the median door-to-needle time dropped by 4.0% (95% confidence interval (CI), 1.4–9.4) from 50 min to 48 min, and the median onset-to-needle time dropped by 2.8% (95% CI, 0.4–5.2) from 180 min to 175 min. As of 31 December 2018, the CSPPC has established 380 stroke centers in mainland China. From 1 November 2018, the CSPPC has monitored the quality of stroke care in stroke center hospitals through the China Stroke Data Center Data Reporting Platform. The CSPPC Stroke program has led to a significant improvement in stroke care. This program needs to be further promoted nationwide.
Methionine-balanced diets improve cattle performance in fattening young bulls fed high-forage diets through changes in nitrogen metabolism

Abstract Ruminants fed high-forage diets usually have a low feed efficiency, and their performances might be limited by methionine (Met) supply. However, the INRA feeding system for growing cattle does not give recommendation for this amino acid (AA). This study aimed to assess the effects of Met-balanced diets on animal performance and N metabolism in young bulls fed high-forage diets formulated at or above protein requirements. Four diets resulting from a factorial arrangement of two protein levels (Normal (13·5 % crude protein) v. High (16·2 % crude protein)) crossed with two Met concentrations (unbalanced (2·0 % of metabolisable protein) v. balanced (2·6 % of metabolisable protein)) were tested on thirty-four fattening Charolais bulls for 7 months before slaughter. Animal growth rate was greater in Met-balanced diets (+8 %; P = 0·02) with a trend for a greater impact in High v. Normal protein diets (P = 0·10). This trend was observed in lower plasma concentrations of branched-chain AA only when Met supplementation was applied to the Normal protein diet (P ≤ 0·06) suggesting another co-limiting AA at Normal protein level. Feed conversion efficiency and N use efficiency were unaffected by Met supplementation (P > 0·05). However, some plasma indicators suggested a better use of AA when High protein diets were balanced v. unbalanced in Met. The proportion of total adipose tissue in carcass increased (+5 percent units; P = 0·03), whereas that of muscle decreased on average 0·8 percent units (P = 0·05) in Met-balanced diets. Our results justify the integration of AA into dietary recommendations for growing cattle.
The possible neurobehavioral protective effects of natural antioxidant against phototoxicity attenuation of antimicrobial quinolone group in rats

The fluoroquinolones absorb light in the 320 to 330 nm ultraviolet A (UV‐A) wavelength and produce reactive oxygen species (ROS) such as superoxide anion, hydroxyl radical, and hydrogen peroxide; thus, the photodynamic generation of ROS may be the basis of phototoxicity of quinolones in human beings and animals. This study aimed to evaluate the damaging effects of UV‐A radiation at different periods of exposure on rats' brains administered with ciprofloxacin. Ciprofloxacin administration in UV‐A exposed animals exaggerated the brain‐oxidative stress biomarkers and decreased the locomotor activity. Exposure of rats to UV‐A for 60 minutes induced a significant increase of malondialdehyde (MDA), myeloperoxidase (MPO), and a decrease in the values of superoxide dismutase (SOD), glutathione (GSH) compared to a normal one; these changes were UV‐A exposure time–dependent. However, the administration of vitamin C to the UV‐60‐treated group decreased the values of MDA, MPO, and shifted the values of SOD, GSH toward the normal values. Vitamin C, probably due to its strong antioxidant properties, could improve and partially counteract the toxic effect of UV‐A on oxidative stress parameters and prevent the damage in rat's brain tissues.
FUpred: detecting protein domains through deep-learning-based contact map prediction

MOTIVATION Protein domains are subunits that can fold and function independently. Correct domain boundary assignment is thus a critical step towards accurate protein structure and function analyses. There is, however, no efficient algorithm available for accurate domain prediction from sequence. The problem is particularly challenging for proteins with discontinuous domains, which consist of domain segments that are separated along the sequence. RESULTS We developed a new algorithm, FUpred, which predicts protein domain boundaries utilizing contact maps created by deep residual neural networks coupled with co-evolutionary precision matrices. The core idea of the algorithm is to retrieve domain boundary locations by maximizing the number of intra-domain contacts, while minimizing the number of inter-domain contacts from the contact maps. FUpred was tested on a large-scale dataset consisting of 2,549 proteins and generated correct single- and multi-domain classifications with an MCC of 0.799, which was 19.1% (or 5.3%) higher than the best machine learning (or threading) based method. For proteins with discontinuous domains, the DBD (domain boundary detection) and NDO (normalized domain overlapping) scores of FUpred were 0.788 and 0.521, respectively, which were 17.3% and 23.8% higher than the best control method. The results demonstrate a new avenue to accurately detect domain composition from sequence alone, especially for discontinuous, multi-domain proteins. AVAILABILITY https://zhanglab.ccmb. med.umich. edu/FUpred. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Uric acid and inflammation in kidney disease.

Asymptomatic hyperuricemia is frequently observed in patients with kidney disease. Although a substantial number of epidemiologic studies have suggested that an elevated uric acid level plays a causative role in the development and progression of kidney disease, whether hyperuricemia is simply a result of decreased renal excretion of uric acid or is a contributor to kidney disease remains a matter of debate. Over the last two decades, multiple experimental studies have expanded the knowledge of the biological effects of uric acid beyond its role in gout. In particular, uric acid induces immune system activation and alters the characteristics of resident kidney cells, such as tubular cells, endothelial cells, and vascular smooth muscle cells, toward a proinflammatory and profibrotic state. These findings have led to an increased awareness of uric acid as a potential and modifiable risk factor in kidney disease. Here, we discuss the effects of uric acid on the immune system and subsequently review the effects of uric acid on the kidneys mainly in the context of inflammation.
Mucosal Vaccination with Lactococcus lactis-Secreting Surface Immunological Protein Induces Humoral and Cellular Immune Protection against Group B Streptococcus in a Murine Model

Group B Streptococcus (GBS) is the primary etiological agent of sepsis and meningitis in newborns and is associated with premature birth and stillbirth. The development of a licensed vaccine is one of the pending challenges for the World Health Organization. Previously, we showed that oral immunization with surface immune protein (SIP) decreases vaginal colonization of GBS and generates functional opsonizing antibodies, which was determined by opsonophagocytic assays (OPA) in vitro. We also showed that the protein has an adjuvant vaccine profile. Therefore, an oral vaccine based on SIP may be an attractive alternative to employ in the development of new vaccines against GBS. Lactococcus lactis is a highlighted oral vaccine probiotic inducer of the mucosal immune response. This bacterium could serve as an antigen-delivering vehicle for the development of an edible vaccine and has been used in clinical trials. In this study, we showed that an oral vaccine with a recombinant L. lactis strain secreting SIP from GBS (rL. lactis-SIP) can induce protective humoral and cellular immunity in an experimental model of GBS vaginal colonization in C57BL/6 mice. Mice immunized with rL. lactis-SIP were protected against clinical symptoms and bacterial colonization after GBS vaginal colonization. Our rL. lactis-SIP vaccine also induces an increase of immunoglobulin G (IgG) and immunoglobulin A (IgA) specifically against SIP. The adoptive transfer of serum from vaccinated mice to naïve mice generated protection against GBS vaginal colonization. Moreover, the rL. lactis-SIP strain induces the activation of SIP-specific T cells, which could decrease GBS vaginal colonization and generate protective antibodies when transferred to other mice. Our experimental observations strongly support the notion that rL. lactis-SIP induces protective humoral and cellular immunity and could be considered as a novel alternative in the development of vaccines for GBS.