Miracle-dz/UniFAR-FTUs huggingface dataset:
Allosteric Inactivation of Caspase-3 Without Major Loop Rearrangements: Properties of the Inactive Ensemble

CADE, CHRISTINE ELIZABETH. Allosteric Inactivation of Caspase-3 Without Major Loop Rearrangements: Properties of the Inactive Ensemble. (Under the direction of Dr. A. Clay Clark.) Allosteric regulation of caspase-3 can occur through binding of small molecules or through mutagenesis. The binding of drugs FICA and DICA to the dimer interface of active caspase-3 induces large conformational changes which convert the enzyme to a zymogenlike form. The V266H mutation in the dimer interface of caspse-3, on the other hand, inactivates the enzyme through subtle changes. Previously, E124A and Y197C mutations were introduced into WT and V266H caspase-3 to study the role of these residues in mediating inhibition of the enzyme. Based on a comparison of WT and V266H crystal structures, additional residues which may also be involved in inhibition were selected for the current study. These residues were located both near the dimer interface and in the active site. One set of mutations in the context of the caspase-3 V266H enzyme attempts to restore activity to the V266H mutant by reducing steric clashes. It was determined that activity can be restored, but amount of activity regained is highest when the restorative mutation is closest to V266H. Control mutants containing only the restorative mutations without V266H were also produced. Another set of mutations were created which attempt to mimic the V266H mutant by introducing steric clashes. In general, these did have lower activity than WT, but a surprising result was seen with the T140F mutant, having only a 4fold lower activity than WT despite introducing a bulky amino acid. Mutations were introduced to probe the significance of the K137-E190 salt bridge, which was found to be transient and unnecessary for activity. The importance of hydrogen bonding between T140 and Y195 was also probed with a T140V mutation, which was found to have 25-fold lower activity than WT. Overall, 17 mutants were assayed for their activity, and x-ray data sets and MD simulations both with and without inhibitor were obtained for 16 of those mutants. Allosteric Inactivation of Caspase-3 Without Major Loop Rearrangements: Properties of the Inactive Ensemble by Christine Elizabeth Cade A dissertation submitted to the Graduate Faculty of North Carolina State University in partial fulfillment of the requirements for the Degree of Doctor of Philosophy
Characterisation of hydrogen peroxide production in a cold atmospheric pressure dielectric barrier discharge

Dielectric Barrier Discharges are used to investigate the production of hydrogen peroxide. Dielectric barriers limit the maximum current, causing microdischarges with the duration of nanoseconds. Water vapor in the gas flow of the plasma is responsible for complex chemistry, leading to the formation of OH radicals and subsequently hydrogen peroxide. Great care is taken to determine the produced amount of hydrogen peroxide. Heating is applied to avoid condensation of water vapour in tubing and hysteresis in the measurements is prevented. The key parameter for the comparison of different discharge geometries is the energy efficiency of the progress. Therefore, a correct measurement of the power dissipation in the discharge is of high importance. Power measurements generally include system losses as well, which reflects on the energy efficiency. System losses are corrected by applying a phase shift to the voltage signal, leading to the power which actually dissipated in the discharge. The production of hydrogen peroxide is studied as a function of the discharge gap size, the gas residence time and the used gas admixture. The energy efficiency turns out to be inversely proportional to the residence time. Minimising the residence time to a few milliseconds results in a energy efficiency up to (1.4± 0.4g/kWh).
“Masterless Men”

On the basis of fieldwork in Kinshasa, this essay makes a link between riots, the recent anthropology of “surplus populations,” and distributive politics in low-income countries, especially Africa. Tracing the history of a political demonstration turned riot, it shows how distribution structures the interactions between rich and poor in the city. Situating the riot in a context in which subjects are dependent on the market for goods but are not able to sell their labor, the essay shows the riot to be a rational intervention in a place where elites do not see popular support as especially important and where occupying space and controlling circulation and distribution are the primary political-economic imperatives.
Neuromuscular and physiological assessment during a vertical jumping test in aerobic gymnastics

In executing aerobic gymnastics technical elements, a high level of explosive power is needed, especially at lower-body muscle groups. In addition, to maintain the specific effort during routine length (1 min 30 s - 1 min 45 s), an optimal development of specific endurance training and a high capacity of focusing is required, in order to execute the technical elements with accuracy. The purpose of this study was to elaborate a testing protocol to evaluate the physical effort capacity necessary to perform specific technical elements in aerobic gymnastics. The proposed testing protocol, is aimed at assessing neuromuscular behavior of lower-body muscle action and the physiological demands, in a maximal vertical jump test (MVJ). The neuromuscular assessment of the of lower-body was achieved by measuring the specific vertical jump parameters, respectively the power in the take-off phase (P) and the height of the jump (JH). The testing protocol consisted of three sets of maximum vertical jumps, lasting 30 s each, with a 15 s rest time between sets. For the physiological demands, as a result of test implementation, heart rate (HR) and the blood lactate concentration (La) were measured. The study was conducted on a group of 13 junior level gymnasts, 7 females and 6 males (aged 14-16 years, average height 163 SD 8.1 cm, average weight 50.69 SD 8.47 kg). The results of this study confirm the proposed methodology reflects an objective view of the physical training status necessary for specific effort accomplishment in aerobic performance gymnastics.
Studies on floral handling time of pollinators on different treatments in sunflower (Helianthus annus L.)

Sunflower, Helianthus annus L. is a valuable crop because of its economic and ornamental benefits. Studies on floral handling time of different pollinators in sunflower were conducted at Anbil Dharmalingam Agricultural College and Research Institute, TNAU, Tiruchirappalli from August, 2019 to October, 2019. Experiment was conducted with seven different treatment such as plants caged with nylon net and allowing Apis cerana indica (T1), plants caged with nylon net and allowing Apis mellifera (T2), flowers sprayed with sugar syrup 5% (T3), flowers sprayed with Probiotic spray 10% (T4), flowers sprayed with cinnamon spray 10% (T5), flowers dusted with sugar dust (T6), open pollination (control) (T7). Observations were recorded on the floral handling time of pollinators. The overall mean obtained from the observation during 7.00 AM to 4.00 PM indicates the predominance of stingless bees (16.07 seconds), which spend more time on flower heads than all other pollinators studied. It was followed by Italian bees (13.37 seconds) and Indian bees (6.07 seconds) whereas the least time was spent by skipper (0.13 seconds). sugar dust treatment (T6) was identified as the best treatment, as floral handling time of pollinators was higher (6.67 seconds) comparing to all other treatments.
ENVIRONMENTALLY FRIENDLY LIFESTYLE BASED ON ECONOMIC EDUCATION

This research is motivated by environmental damage that occurs evenly and continuously due to the lack of knowledge of the community to manage nature to gain profit by not damaging the environment. This can be seen from the many environmental problems that occur such as floods that cannot be handled, landslides, accumulation of household waste, unpredictability of the current weather, and other environmental problems. The amount of environmental damage that occurs shows the lack of public awareness of the importance of protecting the environment whose purpose is for the survival of the community itself because the good or bad condition of an environment is the result of human intervention in it. Researchers are interested in examining the Glintung village community because the people in this village are able to change the image of a densely populated village into an environmentally friendly village. Therefore, the researcher wants to find out how the Glintung village community creates an environmentally friendly environment through the environmental economic education that is obtained and how the goals of sustainable development in this village can be achieved. Descriptive method with a qualitative approach was chosen in this study. The type of research in this research is phenomenology and with three data collection methods, namely interviews, observation, and documentation. The snowball sampling technique was chosen in determining the data source in this study, in which the selection of research subjects took place on a rolling basis. The selection of research subjects took place on a rolling basis, where by observations made previously the researcher chose certain people as informants who were considered to provide the necessary data. Based on data and information obtained from previous informants, researchers can determine other informants. The results of this study indicate that the lifestyle changes of Kampung Glintung people become more environmentally influenced by the support of the surrounding environment and environmental economic education that they get. The education obtained is informal, where the dissemination of knowledge about environmental economics is obtained from training or counseling provided by local officials as well as information by word of mouth between the Glintung village community itself. The change in lifestyle of the Glintung community to become more environmentally friendly is in line with the intended expectations of achieving sustainable development and gradually improving the community's economy. This can be achieved by working together with citizens through simple activities.
Formulation optimisation and characterisation of azithromycin proniosome

The research was featured to formulate, characterise and optimise the Azithromycin Proniosome using the three-factor three-level Box Behnken scheme. The independent variables chosen were span 20 (X1), span 80 (X2) and phospholipids (X3) to assess their individual and shared response on entrapment efficiency (Y1) and % drug released at six h (Y2). Based on Box Behnken design, 15 formulations were prepared and optimised using Design Expert Version 12.0. 10.0. The entrapment efficiency and in-vitro drug release were exposed to different regressions to setup a polynomial equation. The counterplots understood the connections between the independent and dependent factors. The congruity of the polynomial equations was tested by fixing three checkpoint groups. The optimised formulation was determined by point prediction method using the various constraints. The optimised batch was subjected to multiple parameters such as vesicle shape, viscosity, spread ability, drug content, entrapment efficiency, in-vitro drug diffusion and stability studies. The optimised formulation shows better physical and chemical stability which is confirmed by the results of various parameters. The in-vitro drug diffusion has observed to be 98.53% at 24th h obeying zero-order drug release with diffusion mediated non-fickian type of drug release kinetics. The formulation preserved at both refrigerated and room temperature shows better stability. This approach might be an additional finding in enhancing the adherence of patient and improves compliance.
Study the different incidences of Tramadol in different cities of Punjab, Pakistan

Aim and Objective: The objective of this case series is to evaluate the effectiveness of Tramadol according to prescribe-rs and patient's feedback. Methodology: A cross-sectional study to assess pain management practice among patients from different hospitals of Punjab. We conducted this study and collect data from August 2020 to October 2020. A total of 740 patients were included in our study and fulfilled the inclusion criteria. Results: In our results, we find that consumption of opioids in different pain types and concluded that tramadol is the most used opioid among all other opioids. We also found its stability, safety, and efficacy parameters. We confirmed from our study tramadol is used mostly to treat acute musculoskeletal pain. Conclusion: We concluded that tramadol has lower dependency as compare to other recent opioids and have more benefits.
Coexistence of tunneling magnetoresistance and Josephson effects in SFIFS junctions

We demonstrate an integration of tunneling magnetoresistance and the Josephson effects within one tunneling junction. Several sets of Nb-Fe-Al-Al2O3-Fe-Nb wafers with varying Al and Fe layers thickness were prepared to systematically explore the competition of TMR and Josephson effects. A coexistence of the critical current IC(dFe) and the tunneling magnetoresistance ratio T M R(dFe) is observed for iron layer dFe thickness range 1.9 and 2.9 nm. Further optimization such as thinner Al2O3 layer leads to an enhancement of the critical current and thus to an extension of the coexistence regime up to dFe≃3.9 nm Fe.
A Firewall for Neural Networks: Detecting Adversarial Inputs

Neural networks are a double‐edged sword. On the one hand, they are unmatched in prediction accuracy for some tasks, such as image classification. On the other hand, an adversarymaymanipulate predictions of neural networks by forging falsified inputs, e.g., via slight modifications of an input image [1]. Neural networks are not robust against such adversarial inputs and thus unsafe to deploy in some settings.
Teaching Business Models: Introduction to The Special Issue

We develop and evaluate five online courses (MOOCs) on business model innovation, tailored to small and medium sized enterprises (SMEs). Six design principles are found for such courses: regarding type and form of learning contents; time investments from participants; practical examples and tools; integration with daily practice; and participative learning. Please cite this paper as: de Reuver, M. , Cligge, M. , and Haaker, T. (2019), Online courses on business model innovation for practitioners in SMEs, Vol. 7, No. 3, pp. 12-23
Nutrition in pregnancy and pregnancy outcome in two primary health centres, Okpanam

Background: Pregnancy is a nutritionally vulnerable period. The feto-maternal outcomes of pregnancies can be traced to the maternal antepartum nutritional status. Objectives: The study assessed the knowledge of nutrition in pregnancy, nutritional practices in pregnancy and the outcome of the pregnancy for the mother and child among postpartum mothers. Methods: A descriptive survey research of 54 postpartum mothers attending two Primary Health Centres in Okpanam, Delta State. Data collected with a self-developed questionnaire were analyzed using Statistical Package for Social Sciences (SPSS) version 22 and reported in the form of frequency, percentages and pie chart. Results: 90.7% said pregnant women should eat for two, that is, for themselves and the unborn baby, and 35.2% consumed fewer soft drinks during pregnancy. The knowledge level of 50% and nutritional practice level of 42.9% indicated a low level of knowledge on nutrition in pregnancy as well as a low level of nutritional practice in pregnancy. Also, 66.7% of the postpartum mothers had good pregnancy outcome and about 50% of their babies had good pregnancy outcome. Conclusions: Postpartum women had low nutritional knowledge level and low nutritional practice level in pregnancy. The majority had good maternal outcome but only about half of their babies had a good maternal outcome.
Preparation of Dense Thin-Flm Solid Electrolyte on Novel Porous Structure with Parallel Pore Channel

A porous La0.6Sr0. 4Co0.2Fe0. 8O3-Ce0.9Gd0. 1O1.95 (LSCF-CGO) green body was prepared from a water-based slurry by a freeze-drying process. The LSCF-CGO slurry was frozen, controlling the growth direction of ice, and it was sublimated at a reduced pressure. After sintering the green body at 1350°C, the obtained porous substrate has macroscopically aligned open pores parallel to the ice growth direction, and micro pores on their surfaces. It was found that a porous body with such a unique pore structure is the most suitable for integrating a thin film with a porous substrate. A bi-layer consisting of a dense thin-film of CGO on the porous LSCF-CGO substrate has been then fabricated using a slurry-coating process.
Noval Framework for Code Clone Detection and Management

Reusing applications is one of the main practises used to save time in the modern age of app creation. Copying and pasting techniques are used to duplicate applications and the mechanism is called the clone code which is known as code cloning. Yet all of this contributes to questions such as upgrading, upgrading time and sustaining. Different clones have been produced in the literature, but it takes too much time and more room to classify the clones. However, in the paper, authors suggest a new approach in which clones can be found that takes less time than current common algorithms to identify clones. In this paper noval framework using Abstract Syntax Trees for code clone detection and management has been proposed which gives better results in terms of precision and recall.
A Review: Impact of Long Term Zero Tillage on Hydrological Properties of Soils

Zero tillage has the ability to enhance the soil's hydrological properties in the long run. It is the most critical aspect of agriculture for conservation. The need for an hour is conservation farming. It is a win-win operation for farmers as well as for the environment. Although green revolution technologies introduced in the country during 1966-67 led to food security, intensive cultivation, inadequate and imbalanced use of fertilisers, high yielding crop varieties, the use of heavy machinery, excess tillage, etc., for more than five decades resulted in deterioration of soil health and quality and altered the physical matrix and thus hydrological properties. There is a great lack of a systematic approach to linking tillage practises to soil hydrological properties. Soil hydrological characteristics are highly affected by management practises. Tillage aimed to create a soil environment favourable to plant growth on a short-term basis, but noted negative effects on soil properties, structure and ultimately hydrological properties of soils on a long-term basis. Keeping all of these under consideration, this analysis is compiled to create a perfect tillage scheme, i.e. zero tillage, which eliminates the adverse effects of tillage and retains soil resources and eventually contributes to sustainable agriculture. The influence on soil hydrological characteristics, however, depends on the site-specific biophysical environment, such as soil texture, prevailing climate variations, site characteristics, adoption period, and seasonal rainfall variability.
Reactive Power Control on a Consumer Unit with High Integration of PV Generation

The Federal University of Espírito Santo has acquired 5,441 kWp of solar photovoltaic distributed energy resource (DER), which is being installed on the rooftoop of the buildings of the Goiabeiras Campus in the city of Vitória, Espírito Santo, Brazil. Knowing that the solar plant would decrease the metered power factor, this paper analyzed whether the nance revenue of the DER installation may be increased by the injection of reactive power using the DER inverters. Results allow to state that the revenue may be lightly increased. Nevertheless, the costs of a real implementation are not addressed.
Pseudo-lignin retarded bioconversion of sugarcane bagasse holocellulose after liquid hot water and acid pretreatments

Pseudo-lignin derived from the condensation of carbohydrate degradation products can retard the bioconversion of lignocellulose. In this work, liquid hot water (150 to 190 °C) and 1% H2SO4 pretreatments (130 to 190 °C) were used on sugarcane bagasse holocellulose for 3 h to generate pseudo-lignin. The effects of pseudo-lignin generation on structural characteristics and bioconversion of substrates were evaluated. The results showed that the formation of pseudo-lignin increased the hydrophobicity of the substrates. After LHW pretreatments and acid pretreatments at low temperatures (<150 °C), most of the xylans were removed, yielding 2.1 to 5.4% pseudo-lignin. Increasing acid pretreatment temperature to 170 and 190 °C yielded 34.3% and 93.6% pseudo-lignin, respectively. After pretreatment, the accessibilities and bioconversions of substrates were enhanced by degradation of xylans, increasing glucose conversions and bioethanol productions of substrates from 53.2 to 85.3%, and 9.9 to 13.1 g/L, respectively. However, large amounts of pseudo-lignin were generated during acid pretreatments at 170 °C, reducing glucose conversion and bioethanol yield to 45.6% and 6.3 g/L, respectively.
BRAIN COMPUTER INTERFACE SYSTEM USING DEEP CONVOLUTIONAL MACHINE LEARNING METHOD

Brain-computer interface (BCI) decoding connects the human nervous world to the external world. People's brain signals to commands that computer devices can detect. In-depth study the performance of brain-computer interface systems has recently increased. In this article, we will systematically Investigate brain signal types for BCI and explore relevant in-depth study concepts for brain signal analysis. In this study, we have a comparison of different traditional classification algorithms new methods of in-depth study. We explore two different types Deep learning methods, i.e., traditional neural networks Architecture with Long Short term Memory and Repetitive Neural Networks. We check the classification Accuracy of Recent 5-Class Study-State Visual Evoked Opportunities dataset. The results demonstrate in-depth expertise learning methods compared to traditional taxonomy Algorithms.
A Perspective on the Effects of Antigen Shedding on Targeted Delivery of Immunotoxins in Solid Tumors: A Mathematical Model Study

Most tumor cells express specific antigen molecules, and these antigen molecules are shed from the cell surface. In targeted delivery of anti-cancer agents in tumor tissues, immunotoxins or antibody drug conjugates are designed to kill the target cancer cells. Previously, shed antigens were presumed to be a factor preventing the delivery of immunotoxins to solid tumors, since shed antigens act as a decoy to hinder the effective delivery of toxin molecules in solid tumors. However, a recent mathematical model study showed that antigen shedding could be beneficial for the delivery of immunotoxins. In this work, using this mathematical model, the possible condition in which large antigen shedding positively or negatively affects the efficacy of the delivered immunotoxin was thoroughly investigated in terms of three biological variables: number of surface antigen molecules, endocytosis rate constant, and immunotoxin dose. The present study showed that the positive or negative effect of antigen shedding on the delivery efficiency could be modulated by these three key parameters.