Miracle-dz/UniFAR-FTUs huggingface dataset:
Imaging , Diagnosis , Prognosis Measurement of Tumor VEGF-A Levels with 89 Zr-Bevacizumab PET as an Early Biomarker for the Antiangiogenic Effect of Everolimus Treatment in an Ovarian Cancer Xenograft Model

Purpose: The mTOR pathway is frequently activated in ovarian cancers. mTOR inhibitors, such as everolimus, can reduce VEGF-A production by cancer cells. We investigated whether early everolimus treatment effects could be monitored by positron emission tomography (PET) with Zr-bevacizumab. Experimental Design: The effect of everolimus on VEGF-A secretion was determined in a panel of humanovarian cancer cell lines and inA2780lucþovarian cancer cells xenografted subcutaneously inBALB/c mice. Mice received daily 10mg/kg everolimus intraperitoneally (i.p.) for 14 days. PET scans with the tracer Zr-labeled bevacizumab were conducted before and after treatment. Ex vivo Zr-bevacizumab biodistribution and correlative tissue analyses were conducted. Tumor VEGF-A levels were measured with ELISA and mean vascular density (MVD) was determined with immunohistochemistry. Results: Everolimus treatment reduced VEGF-A levels in the supernatant of all cell lines. Everolimus lowered Zr-bevacizumab tumor uptake by 21.7% 4.0% [mean standardized uptake value (SUVmean) 2.3 0.2 vs. 2.9 0.2, P <0.01]. Ex vivobiodistribution also showed lower tracer uptake in the tumors of treated as compared with control animals (7.8 0.8%ID/g vs. 14.0 1.7%ID/g, P < 0.01), whereas no differences were observed for other tissues. This coincided with lower VEGF-A protein levels in tumor lysates in treated versus untreated tumors (P 1⁄4 0.04) and reduced MVD (P < 0.01). Conclusion: Tumor VEGF-A levels are decreased by everolimus. Zr-bevacizumab PET could be used to monitor tumor VEGF-A levels as an early biomarker of the antiangiogenic effect ofmTOR inhibitor therapy. Clin Cancer Res; 18(22); 6306–14. 2012 AACR.
L'acuite de la vision strategique des dirigeants de PME: une etude exploratoire

Le concept de"vision strategique" connait un succes grandissant en Sciences de Gestion depuis quelques annees. Cependant, si la presence d'une vision constitue souvent un element cle du "systeme de gestion" de la OME (Marchesnay, 1992), la question du degre de precision des images mentales produites par le chef d'entreprise peut egalement etre posee, et ce, en raison de leur impact sur la nature, mais aussi la diversite, la complexite et le niveau de formalisation des activites de gestion en PME (Mahe de Boislandelle, 1988; Mintzberg, 1990). Ce travail de recherche s'efforce d'apporter des elements de reponse a cette question, au travers d'une notion nouvelle en management strategique, celle d'"acuite strategique".
Magnetic field control of near-field radiative heat transfer and the realization of highly tunable hyperbolic thermal emitters

We present a comprehensive theoretical study of the magnetic field dependence of the near-field radiative heat transfer (NFRHT) between two parallel plates. We show that when the plates are made of doped semiconductors, the near-field thermal radiation can be severely affected by the application of a static magnetic field. We find that irrespective of its direction, the presence of a magnetic field reduces the radiative heat conductance, and dramatic reductions up to 700% can be found with fields of about 6 T at room temperature. We show that this striking behavior is due to the fact that the magnetic field radically changes the nature of the NFRHT. The field not only affects the electromagnetic surface waves (both plasmons and phonon polaritons) that normally dominate the near-field radiation in doped semiconductors, but it also induces hyperbolic modes that progressively dominate the heat transfer as the field increases. In particular, we show that when the field is perpendicular to the plates, the semiconductors become ideal hyperbolic near-field emitters. More importantly, by changing the magnetic field, the system can be continuously tuned from a situation where the surface waves dominate the heat transfer to a situation where hyperbolic modes completely govern the near-field thermal radiation. We show that this high tunability can be achieved with accessible magnetic fields and very common materials like $n$-doped InSb or Si. Our study paves the way for an active control of NFRHT and it opens the possibility to study unique hyperbolic thermal emitters without the need to resort to complicated metamaterials.
Adaptive Speciation: Sympatric Speciation in Insects

Insect Diversity, Body Size, Specialization, and Speciation Insects are among the most abundant multicellular organisms on earth. Sampling in the tropics and subtropics suggests that there are 10 to 30 million species of insects (Erwin 1982). As a group, invertebrate insects, therefore, represent an inordinately large percentage of the world's fauna, far outnumbering their larger and more conspicuous vertebrate cousins, such as fish (about 24000), amphibians (about 4000), reptiles (7907), birds (9808), and mammals (4629). In fact, the number of species in many families of Heteroptera, Diptera, Coleoptera, and Hymenoptera outnumber the species in most classes of vertebrates. Why are there so many insect species? One apparent reason is body size (Bush 1993). Their small size allows insects to subdivide habitats and specialize on resources that large animals are unable to exploit. Frequently, much of the life cycle occurs exclusively on the resource, which is particularly important since it induces assortative mating. Specialization permits a habitat occupied by a single vertebrate species to support a much greater number of small, often closely related, invertebrate species that can coexist in close sympatry with minimal competition. Vertebrate sister species usually have similar ecological needs, and are seldom sympatric because they competitively exclude one another. In contrast, it is estimated that the majority of insects, over 70% of which either feed on plants or are parasites and parasitoids, are highly host specific (Jaenike 1990). Sister species may sometimes even feed on different parts of the same host.
Sensitivity index based load optimization and impact of FACTS devices in pool and hybrid electricity market model

Congestion management process is very crucial and important for better planning and successful operation of electrical power system. Due to increase in load, power flow for the system must be calculated to ensure system stability and security. In this paper Congestion management is implemented by minimization and optimization of loads. Use of FACTS devices is also included for optimal power flow for congestion management. Nodal price based sensitivity index is also implemented for economic load dispatch using optimal power flow method. IEEE 24 RTS is simulated on PSAT for performance analysis and evaluation.
Productivity ranges of sustainable biomass potentials from non-agricultural land

Land is under pressure from a number of demands, including the need for increased supplies of bioenergy. While bioenergy is an important ingredient in many pathways compatible with reaching the 2 °C target, areas where cultivation of the biomass feedstock would be most productive appear to co-host other important ecosystems services. We categorize global geo-data on land availability into productivity deciles, and provide a geographically explicit assessment of potentials that are concurrent with EU sustainability criteria. The deciles unambiguously classify the global productivity range of potential land currently not in agricultural production for biomass cultivation. Results show that 53 exajoule (EJ) sustainable biomass potential are available from 167 million hectares (Mha) with a productivity above 10 tons of dry matter per hectare and year (tD Mha−1 a−1), while additional 33 EJ are available on 264 Mha with yields between 4 and 10 tD M ha−1 a−1: some regions lose less of their highly productive potentials to sustainability concerns than others and regional contributions to bioenergy potentials shift when less productive land is considered. Challenges to limit developments to the exploitation of sustainable potentials arise in Latin America, Africa and Developing Asia, while new opportunities emerge for Transition Economies and OECD countries to cultivate marginal land.
The state of the left

L abour lost office in 2010 after thirteen years in government the longest stretch of Labour government the party has managed since it was founded a hundred years ago. It more than doubled the previous record, and was marked by three general election victories, the first two, in 1997 and 2001, by decisive margins, at least as measured by parliamentary seats. At long last it appeared that Tony Blair and Gordon Brown had succeeded where Clement Attlee and Harold Wilson had failed, transforming Labour from a party of opposition into a party of government. One sign of this was that although the party lost in 2010 it did not suffer the kind of splits that had taken place after its defeats in 1951, 1970 and 1979. The party has remained remarkably united. The leadership election in 2010 did not offer stark choices between the main candidates, and, with some wobbles, the party united behind its new leader, who has gradually increased in confidence and effectiveness. The party no longer appears to be ideologically divided in the way that it was for most of its twentieth-century history.
Adaptive EEG Decoding for a Brain-Computer Interface

Electroencephalography (EEG) can be used as the basis for a non-invasive brain-computer interface (BCI). The BCI is controlled by μ-band brainwaves (8-15 Hz): imagined activity lowers the spectral power in this band by up to 100 dB compared to relaxation. The original BCI calculated the max or mean of the mu band to detect this difference; these may not be the best functions. This paper presents a system that generates a function to optimally detect this difference. Mu-band data are collected during training sessions, in which a subject is either asked to relax or imagine activity. After a pair of training sessions, a linear combination of simpler functions (e.g. max, min) is found that maximizes the normalized difference between relaxed and active spectrums. This new function is used in the next training session and the process is repeated. We compare six experimental sessions with the previous system to seven with the new system. Trials with the new system showed improved performance (p < 10−8) at distinguishing between active and relaxed states. The subjects had similar performance before the adaptive system was turned on (p = 0.12), indicating that the system was responsible for the improvement, rather than differences in the subject set.
A dual-band 3-dB three-port power divider based on a two-section transmission line transformer

A new dual-band 3-dB three-port power divider with arbitrary impedance terminations is presented in this paper. The structure is composed of a two-section transmission line transformer and an isolation resistor. The transmission line's electrical length is /spl pi//3 each at fundamental frequency, resulting in a 2/spl pi//3 total length. The proposed circuit's design equations and graph obtained from analytical results are also given. The technique is validated by the experimental results on 3-dB 900/1800 MHz power divider with Z/sub s/=100 /spl Omega/ and Z/sub L/=50 /spl Omega/. Good performances of the proposed power combiner/divider at both frequencies are obtained.
Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces

The mechanical and biological properties of bone implants need to be optimal to form a quick and firm connection with the surrounding environment in load bearing applications. Bone is a connective tissue composed of an organic collagenous matrix, a fine dispersion of reinforcing inorganic (calcium phosphate) nanocrystals, and bone-forming and -degrading cells. These different components have a synergistic and hierarchical structure that renders bone tissue properties unique in terms of hardness, flexibility and regenerative capacity. Metallic and polymeric materials offer mechanical strength and/or resilience that are required to simulate bone tissue in load-bearing applications in terms of maximum load, bending and fatigue strength. Nevertheless, the interaction between devices and the surrounding tissue at the implant interface is essential for success or failure of implants. In that respect, coatings can be applied to facilitate the process of bone healing and obtain a continuous transition from living tissue to the synthetic implant. Compounds that are inspired by inorganic (e.g., hydroxyapatite crystals) or organic (e.g., collagen, extracellular matrix components, enzymes) components of bone tissue, are the most obvious candidates for application as implant coating to improve the performance of bone implants. This review provides an overview of recent trends and strategies in surface engineering that are currently investigated to improve the biological performance of bone implants in terms of functionality and biological efficacy.
A theta rhythm in awake macaque V 1 and V 4 1 and its attentional modulation 2

Georgios Spyropoulosa, Conrado A. Bosmanb,c, Pascal Friesa,b,1 3 Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 4 Deutschordenstraße 46, 60528 Frankfurt, Germany, Donders Institute for Brain, Cognition and Behaviour, 5 Radboud University Nijmegen, Kapittelweg 29, 6525 EN Nijmegen, Netherlands, and Swammerdam Institute for 6 Life Sciences, Center for Neuroscience, Faculty of Science, University of Amsterdam, Sciencepark 904, 1098 XH 7 Amsterdam, Netherlands. 8 1To whom correspondence should be addressed. E-mail: pascal.fries@esi-frankfurt.de. 9
Pressure and Temperature Sensor Based on Graphene Diaphragm and Fiber Bragg Gratings

A compact optical fiber sensor based on a Fabry–Perot interferometer (FPI) with an integrated fiber Bragg grating is proposed to measure pressure and temperature simultaneously. The light reflectors of the proposed FPI comprise a graphene film and a fiber end face. The sensitivities of the FPI sensor for measuring pressure and temperature are 501.4 nm/kPa and 306.2 nm/°C, respectively. Conflicting signals of pressure and temperature can cause cross-impact errors at 610 Pa/°C. The introduction of a fiber Bragg grating can effectively prevent the cross-impact of the FPI sensor. The pressure sensitivity obtained is 7.96 to 12 times higher than the previous study. The proposed fiber sensor can simultaneously measure pressure and temperature using a sensitivity matrix.
A Review of Propulsion, Power, and Control Architectures for Insect-Scale Flapping-Wing Vehicles

Flying insects are able to navigate complex and highly dynamic environments, can rapidly change their flight speeds and directions, are robust to environmental disturbances, and are capable of long migratory flights. However, flying robots at similar scales have not yet demonstrated these characteristics autonomously. Recent advances in mesoscale manufacturing, novel actuation, control, and custom integrated circuit (IC) design have enabled the design of insect-scale flapping wing micro air vehicles (MAVs). However, there remain numerous constraints to component technologies—for example, scalable high-energy density power storage—that limit their functionality. This paper highlights the recent developments in the design of small-scale flapping wing MAVs, specifically discussing the various power and actuation technologies selected at various vehicle scales as well as the control architecture and avionics onboard the vehicle. We also outline the challenges associated with creating an integrated insect-scale flapping wing MAV. [DOI: 10.1115/1.4038795]
THE APPLICATION OF MULTIPLE CRITERIA ASSESSMENT OF PRODUCTION SECTORS ON INCREASING QUALITY OF LIFE

The pitfalls of distorted consumption patterns are increasingly clear in modern society. They are seen in the vicious circle of rushed work, earning and spending, which does not generally provide people with greater life satisfaction. As much research has indicated, a 'happiness paradox' occurs. In developed countries, at least, people are not becoming happier, although their material wealth or living standard has continually increased over time. This indicates that other non-material elements of well-being are at least as important as material elements for satisfaction with life. This suggests that a paradigm for social development must be directed away from increasing one-sided economic development at any cost towards sustainable development, if not to maximising the overall happiness in a society. This paper brings an innovative attempt to provide some guidance as to the question which changes in the production structure, beside changes in consumption pattern, could contribute more to higher quality of life. It uses an established method – multi-criteria decision analysis (MCDA) – to combine academic theoretical and empirical work on happiness with the policy goal of increasing quality of life and promoting sustainable development. The use of multiple criteria assessment ranks production sectors on the basis of their contribution to the individual and overall quality of life criteria. The paper addresses the case of Slovenia, though the method is equally applicable in principle to other countries.
Selected Comparisons of Measures of Health Disparities Using Databases Containing Data Relevant to Healthy People 2010 Cancer-Related Goals

This report was written under contract from the Surveillance Research Program (SRP) and the Applied Research Program (ARP) of the Division of Cancer Control and Population Sciences of the National Cancer Institute, NIH. It represents the interest of these organizations in health disparities related to cancer, quantitative assessment and monitoring of these disparities and interventions to remove them. NCI Project Officers for this contract are Marsha E. Reichman, Ph.D. (SRP), Bryce Reeve, Ph.D. (ARP) and Nancy Breen, Ph.D. (ARP).
Aspectos cognitivos da interacao humano-computador multimídia

Este artigo destaca a importancia da abordagem ergonomica en projetos de interfaces humano-computadormultimidia e faz uma revisao sobre os aspectos cognitivos associados a este tipo de interacao. Apresenta uma compilacao de recomendacoes ergonomicas para projetos multimidia sobre o uso adequado das midias -texto, imagem, video, animacao e audio- de acordo com o tipo de informacao a ser apresentada e com as caracterisiticas cognitivas dos usuarios a fim de se obter uma melhor transferencia de informacao.
Anaemia Management in Non-Dialysis Chronic Kidney Disease: Flexibility of Target to Target Stability?

International clinical practice guidelines have recently recognized for the first time the concrete difficulty of keeping chronic kidney disease (CKD) patients within the narrow haemoglobin (Hb) target recommended of 11–12 g/dl (110–120 g/l) because of the variability of individual patient Hb levels. This emerging clinical problem has been the topic of several editorials that, however, exclusively focused on haemodialysis patients. Recently, 3 retrospective studies have been published on Hb variability in non-dialysis CKD. The studies which overall included more than 6,000 patients showed that Hb variability in non-dialysis CKD is greatly prevalent and is associated with a worse cardiorenal outcome. This minireview summarizes the results and limits of these studies and discusses the potential implications for clinical practice.
Dissipation of phenanthrene and anthracene from soil with increasing salt content amended with wastewater sludge

The removal of PAHs was stimulated by wastewater sludge in an alkaline saline soil of the former Lake Texcoco, but not always to the same extent. We investigated how a varying electrolytic conductivity (EC) affected the removal of phenanthrene (PHEN) and anthracene (ANTHR) from wastewater sludge-amended soils. Soil with EC 6, 30, 80, and 146 dS m-1 was contaminated with PHEN and ANTHR and amended with or without wastewater sludge, while emissions of CO2 and concentrations of ammonium, nitrite, and nitrate were monitored. A decrement on the concentrations of PHEN and ANTHR was observed and was faster in soil with EC 6 dS m-1 than in soil with EC 30 dS m-1 and 80 dS m-1, and was slower than in soil with EC 146 dS m-1. Adding wastewater sludge to soil reduced the concentration of PHEN and ANTHR in soil after 56 days. Spiking soil with PAHs or amending it with wastewater sludge increased the CO2 emission rate, but decreased at higher EC. The concentration of NO3 decreased when soil was spiked with PAHs and amended with sludge, except in soil with EC 146 dS m-1. It was found that the removal of PAHs was not inhibited by salt content and a principal component analysis indicated that none of the measured soil characteristics, i.e., pH, EC, particle size distribution, water-holding capacity, or organic C content predicted the removal of ANTHR or PHEN from contaminated soil. The application of wastewater sludge increased the dissipation of PHEN and ANTHR after 56 days.
Generic wind estimation and compensation based on NLGA and RBF-NN

This paper proposes a solution to the aircraft control problem during landing phases in presence of microburst wind shear. This work addresses the design of an adaptive controller which, exploiting the wind estimation provided by suitable filters, improves the flight safety and is able to accomplish the final approach phase even in presence of wind shear. The adaptive controller has been designed by using a backstepping approach and a feedback linearization for time-varying systems. The wind components are estimated by adaptive filters designed by using the tools of both the nonlinear geometric approach and the radial basis function neural network.
Differentially Private Instance-Based Noise Mechanisms in Practice

Differential privacy is a widely used privacy model today, whose privacy guarantees are obtained to the price of a random perturbation of the result. In some situations, basic differentially private mechanisms may add too much noise to reach a reasonable level of privacy. To answer this shortcoming, several works have provided more technically involved mechanisms, using a new paradigm of differentially private mechanisms called instance-based noise mechanisms. In this paper, we exhibit for the first time theoretical conditions for an instance-based noise mechanism to be (∊,δ)-differentially private. We exploit the simplicity of these conditions to design a novel instance-based noise differentially private mechanism. Conducting experimental evaluations, we show that our mechanism compares favorably to existing instance-based noise mechanisms, either regarding time complexity or accuracy of the sanitized result. By contrast with some prior works, our algorithms do not involve the computation of all local sensitivities, a computational task which was proved to be NP hard in some cases, namely for statistic queries on graphs. Our framework is as general as possible and can be used to answer any query, which is in contrast with recent designs of instance-based noise mechanisms where only graph statistics queries are considered.
FPGA based wireless communication system plant monitoring using FPGA

In this paper, a new and productive methodology is introduced to estimate the performance of FPGA based wireless communication system. FPGA devices perform faster and can be customized by user for real time application. Use of FPGA in plant monitoring system gives us lots of choices to solve complicated operations and real time applications too. The momentum and reconstruct ability of FPGA makes this possible.