Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized trial.

CONTEXT Evidence is lacking that a dietary pattern high in vegetables, fruit, and fiber and low in total fat can influence breast cancer recurrence or survival. OBJECTIVE To assess whether a major increase in vegetable, fruit, and fiber intake and a decrease in dietary fat intake reduces the risk of recurrent and new primary breast cancer and all-cause mortality among women with previously treated early stage breast cancer. DESIGN, SETTING, AND PARTICIPANTS Multi-institutional randomized controlled trial of dietary change in 3088 women previously treated for early stage breast cancer who were 18 to 70 years old at diagnosis. Women were enrolled between 1995 and 2000 and followed up through June 1, 2006. INTERVENTION The intervention group (n = 1537) was randomly assigned to receive a telephone counseling program supplemented with cooking classes and newsletters that promoted daily targets of 5 vegetable servings plus 16 oz of vegetable juice; 3 fruit servings; 30 g of fiber; and 15% to 20% of energy intake from fat. The comparison group (n = 1551) was provided with print materials describing the "5-A-Day" dietary guidelines. MAIN OUTCOME MEASURES Invasive breast cancer event (recurrence or new primary) or death from any cause. RESULTS From comparable dietary patterns at baseline, a conservative imputation analysis showed that the intervention group achieved and maintained the following statistically significant differences vs the comparison group through 4 years: servings of vegetables, +65%; fruit, +25%; fiber, +30%, and energy intake from fat, -13%. Plasma carotenoid concentrations validated changes in fruit and vegetable intake. Throughout the study, women in both groups received similar clinical care. Over the mean 7.3-year follow-up, 256 women in the intervention group (16.7%) vs 262 in the comparison group (16.9%) experienced an invasive breast cancer event (adjusted hazard ratio, 0.96; 95% confidence interval, 0.80-1.14; P = .63), and 155 intervention group women (10.1%) vs 160 comparison group women (10.3%) died (adjusted hazard ratio, 0.91; 95% confidence interval, 0.72-1.15; P = .43). No significant interactions were observed between diet group and baseline demographics, characteristics of the original tumor, baseline dietary pattern, or breast cancer treatment. CONCLUSION Among survivors of early stage breast cancer, adoption of a diet that was very high in vegetables, fruit, and fiber and low in fat did not reduce additional breast cancer events or mortality during a 7.3-year follow-up period. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00003787.
Reciprocal Learning among educators in two communities in KwaZulu- Natal

Reciprocal learning among educators in two communities in KwaZulu -Natal This research sets out to analyze the adult learning practices between two groups of secondary school teachers from historically differently resourced schools in the context of a partnership. It seeks to test the nature of the partnership which exists between these schools, and explore the nature of the learning which takes place between the teachers as adult learners. It presents the growth in the learning path between these schools as partners, and points to what will contribute to true reciprocity in this and other community development partnerships where knowledge is a shared resource. It points to personal and community growth in a project which reflects historical apartheid differences between these partners, and suggests how they can move toward disentanglement from potential negative patterns of relating and learning. Reflections on the literature illustrate the issues surrounding the nature of learning among adult learners in shared community relationships. It looks at views on the nature of power relations in community partnerships among adult learners, and contributes to the development of a social learning theory perspective on learning within Communities of Practice. Methodologically this research is qualitative in nature, and has used interaction within the wider Social Responsibility Programme of St Agnes College as a field for interaction. Within that wider programme specifically, the mathematics partnership between Umdodo High School (UHS) and St Agnes was used for data collection. STUART MICHAEL MENNIGKE M. Phil research paper, Faculty of Education. University of the Western Cape. November 2007
Introduction au dossier thématique

La mondialisation impose aux organisations d’innover et se renouveler à un rythme très rapide. Dans un tel contexte, les idées s’imposent comme une ressource centrale et stratégique que l’organisation doit gérer et développer. La créativité organisationnelle devient donc un enjeu de différentiation pour les organisations, et même une réponse à l’enjeu de survie des organisations. Nous proposons d’enrichir les débats relatifs à la créativité organisationnelle en management stratégique en abordant la question de la gestion des idées créatives, de leurs libres parcours dans et en dehors de l’organisation, et de l’émergence de la créativité organisationnelle en tant que capacité créative. Nous concluons par des pistes de recherche à explorer pour caractériser les capacités créatives, et les considérer comme des capacités organisationnelles à part entière.
IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation

Null mutations in the IL1-receptor accessory protein-like 1 gene (IL1RAPL1) are responsible for an inherited X-linked form of cognitive impairment. IL1RAPL1 protein physically interacts with neuronal calcium sensor-1 (NCS-1), but the functional impact of the IL1RAPL1/NCS-1 interaction remains unknown. Here, we demonstrate that stable expression of IL1RAPL1 in PC12 cells induces a specific silencing of N-type voltage-gated calcium channels (N-VGCC) activity that explains a secretion deficit observed in these IL1RAPL1 cells. Importantly, this modulation of VGCC activity is mediated by NCS-1. Indeed, a specific loss-of-function of N-VGCC was observed in PC12 cells overexpressing NCS-1, and a total recovery of N-VGCC activity was obtained by a down-regulation of NCS-1 in IL1RAPL1 cells. The functional relevance of the interaction between IL1RAPL1 and NCS-1 was also suggested by the reduction of neurite elongation observed in nerve growth factor (NGF)-treated IL1RAPL1 cells, a phenotype rescued by NCS-1 inactivation. Because both proteins are highly expressed in neurons, these results suggest that IL1RAPL1-related mental retardation could result from a disruption of N-VGCC and/or NCS-1-dependent synaptic and neuronal activities.
Cholesterol, a Cell Size-dependent Signal That Regulates Glucose Metabolism and Gene Expression in Adipocytes* 210

Enlarged fat cells exhibit modified metabolic capacities, which could be involved in the metabolic complications of obesity at the whole body level. We show here that sterol regulatory element-binding protein 2 (SREBP-2) and its target genes are induced in the adipose tissue of several models of rodent obesity, suggesting cholesterol imbalance in enlarged adipocytes. Within a particular fat pad, larger adipocytes have reduced membrane cholesterol concentrations compared with smaller fat cells, demonstrating that altered cholesterol distribution is characteristic of adipocyte hypertrophy per se. We show that treatment with methyl-β-cyclodextrin, which mimics the membrane cholesterol reduction of hypertrophied adipocytes, induces insulin resistance. We also produced cholesterol depletion by mevastatin treatment, which activates SREBP-2 and its target genes. The analysis of 40 adipocyte genes showed that the response to cholesterol depletion implicated genes involved in cholesterol traffic (caveolin 2, scavenger receptor BI, and ATP binding cassette 1 genes) but also adipocyte-derived secretion products (tumor necrosis factor α, angiotensinogen, and interleukin-6) and proteins involved in energy metabolism (fatty acid synthase, GLUT 4, and UCP3). These data demonstrate that altering cholesterol balance profoundly modifies adipocyte metabolism in a way resembling that seen in hypertrophied fat cells from obese rodents or humans. This is the first evidence that intracellular cholesterol might serve as a link between fat cell size and adipocyte metabolic activity.
Organizational Interfaces for Knowledge Integration in Product Development Collaborations

Through an inductive case study over three years of two product development collaborations, we identified how four organizational interfaces play out over time and how they are related to each other. This study therefore contributes to our understanding of how organizational interfaces evolve and their mutual dependencies in shaping conditions for knowledge integration. Our study extends previous work on organizational interfaces that have either focused on interfaces within the organization or focused on one or two organizational interfaces and their link to knowledge integration without considering the enabling conditions. Our longitudinal approach helps to understand how organizational interfaces play out over time and how they interact and influence each other. Our research helps managers to ask the right questions about how they can design preconditions for knowledge integration in product development collaborations.
Temporospatial Characterization of Brain Oscillations (TSCBO) Associated with Subprocesses of Verbal Working Memory in Schizophrenia

The studies of the neural correlates of verbal working memory in schizophrenia are somewhat inconsistent. This could be related to experimental paradigms that engage differentially working memory components or methodological limitations in terms of characterization of brain activity. Magnetoencephalographic recordings were obtained on 10 schizophrenia patients and 11 healthy controls while performing a modified Sternberg paradigm to investigate subprocesses of verbal working memory. A new method for temporospatial characterization of brain oscillations was applied to whole head recordings and a 1–48 Hz frequency range. Patients differed from controls in event-related synchronization/desynchronization (ERS/ERD) patterns during the encode phase, the mid-maintain phase, and the end of the maintain phase. During the encode phase, patients did not show 1–4 Hz ERS in the left anterior frontal and left parietal lobes. In the mid-maintain phase, the left anterior frontal and left parietal lobes 1–4 Hz ERS, and the bilateral occipital lobes 8–32 Hz ERS were not observed in patients. At the end of the maintain phase, patients did not exhibit 12–48 Hz ERD in the left frontal and parietal lobes. The behavioral data showed reduced primacy effect In schizophrenia, the encode and maintain subprocesses were associated with less ERS and less ERD, respectively. These ERS/ERD abnormalities had specificity in terms of frequency and spatial location. Less ERD reflects reduced complexity of the neural activity, while reduced ERS reflects failure of the neural systems to resume idle state. The impaired primacy effect appears related to specific ERS/ERD patterns in the encode and maintain phases.
Nutritional significance of phytic acid and phytase.

In the nutrition of monogastric animals phytate-P represents a poorly available source of phosphorus, especially in the case of diets low in phytase activity. Similarly the bioavailability of different minerals and trace elements is considerably reduced by phytate complexes. High concentrations of Ca increase the anti-nutritive effect of phytic acid on mineral and trace element bioavailability and thus impede the action of phytase. This effect can in part be compensated by an increased supply of vitamin D. There is also evidence for protective functions of phytic acid such as the prevention of the formation of free radicals, the delaying of post prandial glucose absorption, the decrease in plasma cholesterol and triglycerides as well as a change in the carry over of heavy metals. The basic mechanisms by which phytic acid may exert these effects are still not clear. In several studies reported in the literature, evidence for the nutritional significance and ecological importance of microbial phytase for pigs and poultry has been given. As the monogastric organism contains no or only negligible amounts of endogenous phytase in the stomach and small intestine, it is therefore dependent on plant or microbial phytase. Plant phytase, e.g. from rye, triticale, wheat or, in smaller amounts from barley, and supplemented Aspergillus-phytase display cumulative effects.
Dopamine versus norepinephrine in the treatment of septic shock: A meta-analysis*

Objectives:There has long-been controversy about the possible superiority of norepinephrine compared to dopamine in the treatment of shock. The objective was to evaluate the effects of norepinephrine and dopamine on outcome and adverse events in patients with septic shock. Data Sources:A systematic search of the MEDLINE, Embase, Scopus, and CENTRAL databases, and of Google Scholar, up to June 30, 2011. Study Selection and Data Extraction:All studies providing information on the outcome of patients with septic shock treated with dopamine compared to norepinephrine were included. Observational and randomized trials were analyzed separately. Because time of outcome assessment varied among trials, we evaluated 28-day mortality or closest estimate. Heterogeneity among trials was assessed using the Cochrane Q homogeneity test. A Forest plot was constructed and the aggregate relative risk of death was computed. Potential publication bias was evaluated using funnel plots. Methods and Main Results:We retrieved five observational (1,360 patients) and six randomized (1,408 patients) trials, totaling 2,768 patients (1,474 who received norepinephrine and 1,294 who received dopamine). In observational studies, among which there was significant heterogeneity (p < .001), there was no difference in mortality (relative risk, 1.09; confidence interval, 0.84–1.41; p = .72). A sensitivity analysis identified one trial as being responsible for the heterogeneity; after exclusion of that trial, no heterogeneity was observed and dopamine administration was associated with an increased risk of death (relative risk, 1.23; confidence interval, 1.05–1.43; p < .01). In randomized trials, for which no heterogeneity or publication bias was detected (p = .77), dopamine was associated with an increased risk of death (relative risk, 1.12; confidence interval, 1.01–1.20; p = .035). In the two trials that reported arrhythmias, these were more frequent with dopamine than with norepinephrine (relative risk, 2.34; confidence interval, 1.46–3.77; p = .001). Conclusions:In patients with septic shock, dopamine administration is associated with greater mortality and a higher incidence of arrhythmic events compared to norepinephrine administration.
Legionella micdadei and Legionella dumoffii monoclonal antibodies for laboratory diagnosis of Legionella infections

Two different monoclonal antibodies directed against Legionella micdadei and L. dumoffii (Genetic Systems Corp., Seattle, Wash.) were evaluated for their specificity and ability to detect L. micdadei and L. dumoffii in human and animal clinical samples and bacterial isolates in an indirect immunofluorescence assay. All three frozen sputum samples and all three Formalin-fixed sputum and liver samples from patients with culture-documented L. micdadei pneumonia were positive when tested with the L. micdadei monoclonal antibody. A Formalin-preserved lung sample from a patient with culture-documented L. dumoffii pneumonia was positive with its homologous monoclonal antibody. No cross-staining reactions were found with either monoclonal antibody on any of 25 human sputum samples tested from patients without Legionella infections. A total of 66 Legionella strains and 56 non-Legionella strains including 22 Pseudomonas strains and 34 other bacterial strains were studied. No cross-staining reactions were found except in Staphylococcus aureus Cowan 1 ATCC 12598. The lower limit of detection in seeded sputum samples was about 7 X 10(4) cells per ml for both monoclonal antibodies. Lung and tracheal lavage specimens from L. micdadei- or L. dumoffii-infected guinea pigs showed specific staining only with their respective monoclonal antibodies. The monoclonal antibodies stained homologous bacteria slightly less intensely than did the polyclonal antisera, but the signal-to-noise ratio was considerably higher for the monoclonal antibodies. No differences in sensitivity of staining of clinical specimens or bacterial isolates were noted between the monoclonal antibodies and the polyclonal reagents for L. micdadei and L. dumoffii (Centers for Disease Control, Atlanta, Ga. , and BioDx, Denville, N.J. These monoclonal antibodies ae sensitive and specific, making them good candidates for laboratory diagnostic purposes.
Socioeconomic Status Is Associated With Stress Hormones

Objective: We assess whether socioeconomic status (SES) is associated with basal levels of cortisol and catecholamines and determine if any association between SES and these hormones can be explained (is mediated) by behavioral, social, and emotional differences across the SES gradient. Methods: One hundred ninety-three adult subjects, including men and women and whites and African-Americans, provided 24-hour urine catecholamine samples on each of 2 days and seven saliva cortisol samples on each of 3 days beginning 1 hour after wakeup and ending 14 to 16 hours later. Values for both hormones were averaged across days to obtain basal levels. Results: Lower SES (income and education) was associated with higher levels of cortisol and epinephrine and marginally higher levels of norepinephrine. These associations were independent of race, age, gender, and body mass. Low SES was also associated with a greater likelihood of smoking, of not eating breakfast, and with less diverse social networks. Further analyses provided evidence consistent with the hypothesis that these behavioral and social variables mediate the link between SES and the three stress hormones. Conclusions: Lower SES was associated in a graded fashion with higher basal levels of cortisol and catecholamines. These associations occurred independent of race, and the data were consistent with mediation by health practices and social factors. AUC = area under the curve; BMI = body mass index; CARDIA = Coronary Artery Risk Development in Young Adults Study; ELISA = enzyme-linked immunosorbent assay; HPA = hypothalamic-pituitary adrenocortical axis; ISEL = Interpersonal Support Evaluation List; LET = Life Engagement Test; SES = socioeconomic status; SNS = sympathetic nervous system.
The Transition to Adulthood in Individualistic and Collectivistic Cultures: Prevalence and Timing of Premarital Cohabitation and First Marriage in Germany and China

Abstract In recent years, Asian countries have experienced rising rates of premarital cohabitation, mirroring a similar trend that could be observed in many European countries several decades ago. As international differences in these trends are often attributed to institutional and societal differences, this study explores how China’s and Germany’s welfare and cultural regimes relate to national differences in the timing and prevalence of premarital cohabitation and direct marriage. On the basis of two post-hoc harmonized surveys (pairfam for Germany; CFPS for China), descriptive analyses and logistic regressions were conducted. A higher standardization of partnership trajectories during the transition to adulthood was observed in China; this being probably related to China’s collectivist and Germany’s individualistic culture. While urban–rural differences prevail in China, and are attributable to China’s hukou system, East and West Germans differ considerably in this regard, a finding which can be traced back to regional differences in historical legacy. Discrepancies in economic modernization explain why the likelihood of experiencing these events differs for individuals in the Eastern and Western Chinese provinces. Besides these differences, the two national contexts resemble each other in the prevalence of educational hypergamy, as well as in greater rates of cohabitation prior to first marriage, in contrast to direct marriage, seen among wealthier individuals and those with higher education. For the first time, the effects of cultural and institutional differences on the transition to adulthood were compared between a collectivistic vs. individualistic cultural regime and a productivist vs. corporatist conservative welfare regime, enabling researchers to draw conclusions about the link between cultural and welfare regime types and partnership patterns.
An Algorithm Exploiting Episodes of Inefficient Asset Pricing to Derive a Macro-Foundation Scaled Metric for Systemic Risk: A Time-Series Martingale Representation

This paper employs an event study, the Global Financial Crisis. Episodes of inefficient pricing, the externality, are exploited as a measure of systemic risk. The theoretical asset pricing model, the martingale representation, is shown to be a valid algorithm to identify episodes of efficient and inefficient pricing in time series. Systemic risk metrics are derived from episodes of inefficient pricing, utilizing a shadow volatility metric. The algorithm is forward looking, deriving macro-foundation metrics from actual agent market behavior. The algorithm provides precise risk metrics for magnitude and diffusion using US and Canadian treasury markets. Given the US dollarâ€™s role as the de-facto world reserve currency, scaled metrics derived from the US treasury market provide a globalized systemic benchmark. The risk metrics signal the crisis buildup and calibrate around the crisis epicenter date of September 2008. The risk metrics are heuristically consistent with the stylized facts of financial crises and support the extraordinary US policy response to the crisis. The algorithm output is validated by time-series analysis.JEL classification numbers: C22, C61, G01, G12, G14Keywords: Systemic Risk, Time Series, Optimization, Financial Crises, Asset Pricing.
Levels and temporal trend of bisphenol A in composite food samples from Canadian Total Diet Study 2008–2012

Food composite samples from the Canadian Total Diet Study which was conducted each year from 2008 to 2012 rotating between different cities were analysed for bisphenol A (BPA). The overall levels of BPA in the composite food samples from each of the five years from 2008 to 2012 were similar in general with averages (range) of 7.7 ng/g (0.20–106 ng/g), 7.8 ng/g (0.26–110 ng/g), 6.9 ng/g (0.20–84 ng/g), 7.7 ng/g (0.20–105 ng/g) and 9.0 ng/g (0.15–90 ng/g) for 2008, 2009, 2010, 2011 and 2012, respectively. Levels of BPA in most of the non-canned food composite samples were low and no particular trends were observed. In contrast, the trend of BPA levels in canned food composite samples over the five years (2008–2012) varies. BPA levels in most of the canned food composite samples from 2008 to 2012 were consistent in general (e.g. canned luncheon meat: 10–18 ng/g, canned baked beans: 18–25 ng/g). While BPA levels over the five years were found to decrease for some canned food composite samples (e.g., canned fish: 109 ng/g in 2009 vs. 51 ng/g in 2012), they were also found to increase for some other canned food composite samples (e.g. canned meat soups: 90–104 ng/g in 2011–2012 vs. 29 ng/g in 2008). Thus, recent changes in can coating for food packaging to BPA-free alternatives may have not been fully reflected in all canned food products over the period from 2008 to 2012. Continued monitoring is necessary to more fully assess the potential impact on dietary exposure by the use of BPA alternatives in food contact materials.