Miracle-dz/UniFAR-FTUs huggingface dataset:
Vascular events in Korean patients with myeloproliferative neoplasms and their relationship to JAK2 mutation

Summary Evaluation of the Janus kinase 2 (JAK2) V617F mutation has been widely used for the diagnosis of myeloproliferative neoplasms (MPN). However, its prognostic relevance to clinical outcome is not completely understood. We investigated the association of JAK2 V617F with vascular events in Korean patients with myeloproliferative neoplasms (MPN). We studied 283 patients from 15 centers, who were diagnosed with MPN. The JAK2 V617F status was evaluated by allele-specific polymerase chain reaction (PCR) and sequencing. The patients’ diagnoses were essential thrombocythemia (ET n=146), polycythemia vera (PV n=120), primary myelofibrosis (n=12), and unclassifiable MPN (MPNu n=5). JAK2 V617F was detected in 89 (61%) patients with ET, 103 (86%) with PV, four (33%) with myelofibrosis, and four (80%) with MPNu. A higher number of leukocytes, haemoglobin levels and BM cellularity as well as an older age, lower platelet counts, and diagnosis of PV were significantly correlated with JAK2 V617F. Eighty-three and 43 episodes of thrombosis and bleeding occurred in 100 patients each before and after the diagnosis. Vascular events more frequently occurred in 37% of patients with JAK2 V617F than in 29% of those without the mutation (p=0.045). Among 175 patients whose samples were available for sequencing, 28 patients with homozygous JAK2 V617F had vascular events more frequently (57%) than those who were heterozygotes (39%) or had the wild type (27%) (p=0.03). The multivariate analysis showed that a JAK2 homozygous mutation, hypercholesterolemia and older age were independent risk factors for a vascular event. The results of this study showed that Korean patients with MPN had a similar JAK2 mutation rate and frequency of vascular events when compared to Western patients. The presence of V617F was significantly related to vascular events. Therefore, initial evaluation for the JAK2 mutation and careful monitoring for vascular events should be performed in MPN patients.
Analysis of multiport passive components using admittance matrix

Based on the network matrix conversion from scatter parameters to admittance parameters, a novel analysis method for multiport passive components is presented. Unlike the traditional even- and odd-mode analysis only being used for symmetrical structure, this kind of method is no limited. In this paper, three examples, such as Wilkinson power divider, 180° ring hybrids and quadrature (90°) hybrids with arbitrary port impedances are researched. Analysis results show that design formulas obtained from new method agree with ones reported by class literatures, but the calculation process is much simpler than class methods obviously.
Maternal Attachment Representations and Initiation and Duration of Breastfeeding

Despite the evidence that there are considerable benefits of breastfeeding, there are still gaps in understanding why many women have difficulties initiating and maintaining breastfeeding. In this prospective longitudinal study, the factors affecting the initiation and duration of breastfeeding were expanded to include attachment representations, which are known to influence health behaviors as well as one’s ability to cope with stressful situations. Participants (n = 460) completed attachment and depression questionnaires during a prenatal clinic appointment, and in the postpartum period, mothers reported on their mood and breastfeeding behaviors. Consistent with attachment theory and previous research, women with attachment approach orientations were more likely to breastfeed, breastfeed longer, and continue breastfeeding when they experienced initial difficulties. The results of this study demonstrate that it is important to look beyond demographics to understand breastfeeding initiation and duration and provide further evidence that attachment representations influence health decisions.
Pulpar temperature changes during mechanical reduction of equine cheek teeth: comparison of different motorised dental instruments, duration of treatments and use of water cooling.

REASONS FOR PERFORMING STUDY Although equine motorised dental instruments are widely used, there is limited information on their thermal effect on teeth. The recently described variation in subocclusal secondary dentine depth overlying individual pulp horns may affect heat transmission to the underlying pulps. OBJECTIVES This study compared the effect of 3 different equine motorised dental instruments on the pulpar temperature of equine cheek teeth with and without the use of water cooling. It also evaluated the effect of subocclusal secondary dentine thickness on pulpar temperature changes. METHODS A thermocouple probe was inserted into the pulp horns of 188 transversely sectioned maxillary cheek teeth with its tip lying subocclusally. Pulpar temperature changes were recorded during and following the continuous use of 3 different equine motorised dental instruments (A, B and C) for sequential time periods, with and without the use of water cooling. RESULTS Using motorised dental instrument B compared with either A or C increased the likelihood that the critical temperature was reached in pulps by 8.6 times. Compared with rasping for 30 s, rasping for 45, 60 and 90 s increased the likelihood that the critical temperature would be reached in pulps by 7.3, 8.9 and 24.7 times, respectively. Thicker subocclusal secondary dentine (odds ratio [OR] = 0.75/mm) and water cooling (OR = 0.14) were both protective against the likelihood of the pulp reaching the critical temperature. CONCLUSIONS Prolonged rasping with motorised dental instruments increased the likelihood that a pulp would be heated above the critical temperature. Increased dentinal thickness and water cooling had protective roles in reducing pulpar heating. POTENTIAL RELEVANCE Motorised dental instruments have the potential to seriously damage equine pulp if used inappropriately. Higher speed motorised dental instruments should be used for less time and teeth should be water cooled during or immediately after instrument use to reduce the risk of thermal pulpar damage.
Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences.

RATIONALE Idiopathic pulmonary fibrosis (IPF) has an unknown etiology and poor prognosis. Several large-scale epidemiologic studies have been conducted predominantly in Western countries. There are few studies reported from Asian countries. It remains unclear whether ethnic difference exists in IPF. It is important to determine the current IPF status in Asian populations and compare it with that of Western populations. OBJECTIVES To provide the epidemiologic status of IPF in Japan and to investigate ethnic differences. METHODS We selected Hokkaido prefecture (population, 5.6 million) as the epidemiologic cohort of IPF among Japanese. On the basis of the clinical records of 553 patients with IPF who were accepted based on the application of the Certificate of Medical Benefit between 2003 and 2007, we conducted a retrospective epidemiologic and prognostic analysis. MEASUREMENTS AND MAIN RESULTS The prevalence and cumulative incidence of IPF was 10.0 and 2.23 per 100,000 population, respectively, with 72.7% predominance of males and an increase in frequency with age. The median survival time was 35 months, and the most common (40%) cause of death was acute exacerbation. The most important factor influencing IPF prognosis was the percent vital capacity. CONCLUSIONS The status of IPF in the Japanese population was clarified for the first time through our study. Our results showed that in men, the incidence of death caused by acute exacerbation was higher and that caused by cardiovascular disease was lower in Japan than in Western countries. These results may suggest ethnic differences in IPF.
N′-(5-Bromo-2-methoxybenzylidene)-2-methoxybenzohydrazide

The title hydrazone compound, C16H15BrN2O3, adopts an E configuration about the C=N double bond. The molecule is twisted, the dihedral angle between the two substituted benzene rings being 22.0 (2)°. In the crystal structure, molecules are linked through intermolecular N—H⋯O hydrogen bonds, forming chains along the c axis.
Virtual Reality in the Assessment of Selected Cognitive Function After Brain Injury

Zhang L, Abreu BC, Masel B, Scheibel RS, Christiansen CH, Huddleston N, Ottenbacher KJ: Virtual reality in the assessment of selected cognitive function after brain injury. Am J Phys Med Rehabil 2001;80:597–604. ObjectiveTo assess selected cognitive functions of persons with traumatic brain injury using a computer-simulated virtual reality environment. Study DesignA computer-simulated virtual kitchen was used to assess the ability of 30 patients with brain injury and 30 volunteers without brain injury to process and sequence information. The overall assessment score was based on the number of correct responses and the time needed to complete daily living tasks. Identical daily living tasks were tested and scored in participants with and without brain injury. Each subject was evaluated twice within 7 to 10 days. A total of 30 tasks were categorized as follows: information processing, problem solving, logical sequencing, and speed of responding. ResultsPersons with brain injuries consistently demonstrated a significant decrease in the ability to process information (P = 0.04–0.01), identify logical sequencing (P = 0.04–0.01), and complete the overall assessment (P < 0.01), compared with volunteers without brain injury. The time needed to process tasks, representing speed of cognitive responding, was also significantly different between the two groups (P < 0.01). ConclusionA computer-generated virtual reality environment represents a reproducible tool to assess selected cognitive functions and can be used as a supplement to traditional rehabilitation assessment in persons with acquired brain injury.
Efficient sorting of TNF‐alpha to rodent mast cell granules is dependent on N‐linked glycosylation

Mast cells play an important role at the early stages of immunological response to bacterial infections and parasite infestations. One of the major mast cell proinflammatory mediators is TNF‐α. Mast cells are considered the only cells capable of storing TNF‐α in cytoplasmic granules and rapidly releasing it upon activation. To determine what pathway is utilized to direct TNF‐α to cytoplasmic granules and what motifs are responsible for the sorting process, we constructed a fusion protein covering the full sequence of TNF‐α, N‐terminally fused to enhanced green fluorescent protein (EGFP). In rodent mast cells, such protein was sorted to secretory granules, and this process was inhibited by both brefeldin A and monensin. Considering the relationship between lysosomes and secretory granules and following TNF‐α sequence analysis, it was determined whether TNF‐α is sorted through the mannose‐6‐phosphate receptor (MPR)‐dependent pathway. We observed that ammonium chloride and tunicamycin blocked TNF‐α‐EGFP fusion protein delivery to secretory granules. In situ mutagenesis experiments confirmed the necessity of N‐linked glycosylation for efficient sorting of TNF‐α into rodent mast cell granules. In this work we established that TNF‐α travels from the ER to mast cell granules via a brefeldin A‐ and monensin‐sensitive route, utilizing the MPR‐dependent pathway, although this dependency does not seem to be absolute.
Evolutionary Image Co-clustering with User Feedbacks

Traditional image clustering systems are primarily based on visual and/or textual features. Such algorithms commonly suffer from the problem of semantic gap. General approach to overcome this problem is to incorporate user feedback. However, data extracted from certain domains like social networks, web-blogs etc. is evolving in nature. In other words, data collected from such domains over small period of time interval exhibits high similarity over data instances and features, which can be effectively used to optimize data clustering since change in clustering is gradual. In this paper, we propose EHCC (Evolutionary starstructured Heterogeneous Co-Clustering) algorithm for image co-clustering. Our algorithm incorporates user provided feedbacks over period of time to guide coclustering process. We incorporate user provided feedback in terms of image similarity logs over period of time to augment relational matrix obtained from low level features (color and textual features) extracted from images. Through an iterative algorithm, we trifactorize new relational matrix to obtain image clusters. Through extensive experiments on image data sets, we demonstrate effectiveness and efficiency of our proposed algorithm. keywords: image, clustering, user, feedback, matrix, factorization.
Comparison of Multidimensional Measures of Aggression

Despite the research generated on two of the most widely employed measures of aggression, the Buss-Durkee Hostility Inventory and the Rosenzweig Picture-Frustration Study, there has been no analysis of the relationship between scores on these tests although such information permits evaluation of the redundacy of these measures. 122 university students completed both measures and also the Desirability Scale from the Jackson Personality Research Form. Analysis yielded generally low correlations which followed predictable patterns. Overlap was found only in outwardly directed displays of aggression. The Desirability Scale was significantly correlated with dimensions of the Picture-Frustration Study but was uncorrelated with Buss-Durkee scores.
Condylomata, cytological abnormalities and human papillomavirus infection in the anal canal in HIV‐infected men

Genital infections with low‐risk (LR) and high‐risk (HR) human papillomavirus (HPV) genotypes are associated with ano‐genital condylomata and anal squamous cell cancer. HPV‐related pathologies in HIV‐infected men are a serious concern. In this study, the prevalence of anal condylomata and their association with cytological abnormalities and HPV infection in the anal canal in HIV‐infected men [men who have sex with men (MSM) and heterosexuals] were estimated.
The Dynamics of Resettlement with reference to the Ethiopian Experience

This paper is a summary of a thesis submitted to the Kimmage Development Studies Centre, Dublin in partial fulfillment of the requirements for the degree of MA in Development Studies. The paper focuses on the dynamics of resettlement with reference to the Ethiopian experience. Because of rapid economic growth, population pressure and the degradation of natural resources, the resettlement of people to new locations has become a dominant development discourse in many parts of the world. Research evidence suggests, however, that many such initiatives have not brought positive results. Broadly, there are two divergent arguments as to why resettlement often fails to improve the situation of the people concerned. Some argue that it is an inherently complex process, emanating from unfair wealth distribution. Others, on the contrary, say that it is an inevitable consequence of development and that what matters is the presence of efficient and effective frameworks to plan and implement it. The aim of the research I conducted in 2006 in a government-sponsored resettlement scheme in Southern Ethiopia was to assess these arguments, with the help of empirical evidence provided largely by the affected people themselves. This evidence suggested that the resettlement scheme had both positive and negative aspects. This paper argues that resettlement could be a viable strategy for solving the pressing problem of food insecurity in Ethiopia, but if it is implemented on a large scale, without in-depth feasibility studies, proper planning or adequate resources, it could have multiple negative impacts, both on resettlers and the environment. Resettlement may indeed offer improved livelihoods for those who move voluntarily, provided it is done on a manageable scale with sufficient government resources; that it is implemented within a relatively small geographical area and within a relatively homogeneous ecological zone; and that it is planned and executed with proper care and support for the resettlers.
Reversible chemical patterning on stimuli-responsive polymer film: environment-responsive lithography.

We report on a novel type of chemical patterning based on thin stimuli-responsive polymer films. The basic concept is the permanent storage (writing) of a pattern, which is reversibly developed and erased upon exposure to appropriate environment, e.g., solvent, pH, and temperature. The smart surface is fabricated from the mixed brush of poly(2-vinylpyridine) and polyisoprene. The mixed brush demonstrates switching behavior upon exposure to different solvents. Cross-linking of polyisoprene via illumination through a photomask results in formation of patterns with suppressed switching. Due to the contrast in switching between illuminated and dark areas, exposure of the smart surface to different solvents causes either reversible formation or erasing of chemical contrast between the illuminated and dark areas. Thus, the pattern surface can very locally attract colloidal particles or can be wetted by water only upon exposure to the special solvent which introduces the contrast between the illuminated and dark areas. Appearance of the patterns indicates particular environment and can be used for local switching of adsorption.
UWB Circular Slot Antenna Provided with an Inverted-L Notch Filter for the 5 GHz WLAN Band

Abstract—The study of a planar circular slot antenna for Ultrawideband (UWB) communications is presented. The integration on this antenna of a notch filter, to reduce the possible interferences with the 5GHz WLAN communications, has been discussed in detail. Four different structures, achieved by etching a suitable pattern on the antenna circular stub, have been considered, and their features have been compared. The antenna with symmetrical and inverted-L cuts shows the best performance, and it has been therefore realized and fully characterized. It shows very good matching features over the UWB band, and notable rejection of the 5 GHz WLAN band.
Time Series Indexing Taking Advantage of the Generalized Suffix Tree

A time series is a collection of observations made sequentially over time. Time series appear in several application areas such as finance, marketing, agriculture, weather, industrial and scientific data gathering. Similarity searching on time series databases is an important tool to extract knowledge from them. In this article, we propose Telesto, a novel indexing approach aimed at performing similarity search over time series, which is based on discretized time series and generalized suffix trees. Initially, Telesto discretizes time series and represents them as strings, using as a basis the Symbolic Aggregate Approximation (SAX) technique. Thereafter, these strings are indexed using a generalized suffix tree. To provide both range and nearest neighbor query operations among discretized time series, Telesto extends the suffix tree substring search algorithm by calculating distances between the discretized time series. Performance tests showed that Telesto is scalable in response to increasing sizes of databases and queries, in addition to be very efficient in similarity queries over large real-world time series databases.
Direct subsidy incentive capacity restoration contract under supply disruption risk

Consider a supply chain consists of a supplier and a buyer. The supplier faces a risk of disruption and could rebuild the capacity if he has invested before the disruption. To motivate the supplier to invest and share the burden of capacity restoration, the buyer adopts a direct subsidy incentive contract. For this incentive contract, the buyer provides financial subsidy to share the capacity restoration cost of the supplier if there is a disruption. We also consider contract timing problem. We compare the Ex Post commitment strategy (the incentive contract is offered after disruption) and Ex Ante commitment strategy (the incentive contract is offered before disruption). We find that Ex Ante commitment strategy dominates Ex Post commitment strategy because it provides a wider parameter range for the investment decision of the supplier, and leads to profit improvement for both the supplier and the buyer.
Consistent parameter estimation in general stochastic block models with overlaps

This paper considers the parameter estimation problem in Stochastic Block Model with Overlaps (SBMO), which is a quite general instance of random graph model allowing for overlapping community structure. We present the new algorithm successive projection overlapping clustering (SPOC) which combines the ideas of spectral clustering and geometric approach for separable non-negative matrix factorization. The proposed algorithm is provably consistent under SBMO with general conditions on the parameters of the model. SPOC is also shown to perform well experimentally in comparison to other algorithms.
Tristetraprolin Regulates CXCL1 (KC) mRNA Stability1

mRNAs encoding proinflammatory chemokines are regulated posttranscriptionally via adenine-uridine-rich sequences (AREs) located in the 3′ untranslated region of the message, which are recognized by sequence-specific RNA-binding proteins. One ARE binding protein, tristetraprolin (TTP), has been implicated in regulating the stability of several ARE-containing mRNAs, including those encoding TNF-α and GM-CSF. In the present report we examined the role of TTP in regulating the decay of the mouse chemokine KC (CXCL1) mRNA. Using tetR-regulated control of transcription in TTP-deficient HEK293 cells, KC mRNA half-life was markedly decreased in the presence of TTP. Deletion and site-specific mutagenesis were used to identify multiple AUUUA sequence determinants responsible for TTP sensitivity. Although a number of studies suggest that the destabilizing activity of TTP is subject to modulation in response to ligands of Toll/IL-1 family receptors, decay mediated by TTP in 293 cells was not sensitive to stimulation with IL-1α. Using primary macrophages from wild-type and TTP-deficient mice, KC mRNA instability was found to be highly dependent on TTP. Furthermore, LPS-mediated stabilization of KC mRNA is blocked by inhibition of the p38 MAPK in macrophages from wild-type but not TTP-deficient mice. These findings demonstrate that TTP is the predominant regulator of KC mRNA decay in mononuclear phagocytes acting via multiple 3′-untranslated region-localized AREs. Nevertheless, KC mRNA remains highly unstable in cells that do not express TTP, suggesting that additional determinants of instability and stimulus sensitivity may operate in cell populations where TTP is not expressed.
History of Ancient Copper Smelting Pollution During Roman and Medieval Times Recorded in Greenland Ice

Determination of copper concentrations in Greenland ice dated from seven millennia ago to the present showed values exceeding natural levels, beginning about 2500 years ago. This early large-scale pollution of the atmosphere of the Northern Hemisphere is attributed to emissions from the crude, highly polluting smelting technologies used for copper production during Roman and medieval times, especially in Europe and China. This study opens the way to a quantitative assessment of the history of early metal production, which was instrumental in the development of human cultures during ancient eras.