Miracle-dz/UniFAR-FTUs huggingface dataset:
Structural and pain modifications in models of osteoarthritis

Background: Despite the extensive research into the pathophysiology of osteoarthritis (OA), pain still represents a significant unmet clinical need. This thesis explores the effects of a tropomyosin related kinase A receptor (TrkA) inhibitor and an anti-nerve growth factor (NGF) antibody as interventions to modify inflammation, structural pathology and pain behaviour in rat models of OA. Methods: Rat models of OA (monosodium iodoacetate - MIA and medial meniscal transection – MNX) were assessed for pain behaviour and pathology. Effect of interventions on pain behaviour (weight bearing asymmetry and paw withdrawal thresholds) and structural pathology (macroscopic and microscopic scoring of articular surfaces) to include inflammation were assessed using inhibitors of the NGF-TrkA pathway. Pain Data were analysed longitudinally using area under the curve or independently with Kruskal Wallis test followed by Dunns post hoc. Other data were analysed with Kruskal Wallis test followed by Dunns post hoc. Results: The MIA and MNX models all exhibited inflammation and pain behaviour. The MIA and MNX models displayed both macroscopic and microscopic pathology. Following preventive or therapeutic treatment with the tropomyosin receptor kinase (Trk) A inhibitor AR786, pain behaviour was inhibited in both MIA and MNX models. Synovitis was attenuated only in the MIA model. Analgesia was sustained for up to 10 days in the MNX model following AR786 treatment discontinuation. Preventive and therapeutic treatment with the anti–NGF monoclonal antibody M911 did not alter changes to cartilage pathology. Conclusions: Manifestation of pain, inflammation and alterations in knee joint structure are characteristic features of OA models. NGF might contribute to OA pain through the NGF-TrkA pathway. This contribution might be as a result of facilitating nociception, and inflammation. Further investigation into the mechanisms by which NGF contributes to OA pain through the TrkA receptor might increase therapeutic potential for OA chronic pain relief.
ANALYSIS OF CLOUDINESS BY SEGMENTATION AND MONITORING OF SATELLITE MAP IMAGES

The algorithm of the dynamic threshold segmentation of images using clipping plane in a three-dimensional XYZ image space is proposed. To build the clipping plane of the dynamic threshold the precession and nutation angles as the base threshold values are found. The developed algorithm is applied to the satellite map images to get cloudiness intensity. The satellite map images are transformed by segmentation and inversion. The segmented and inverted images are scanned to receive the distributed cumulative histograms. By the help of so-called cloudiness meter the statistical data is processed for calculation and monitoring of cloudiness in Ukraine. The formulas to create an image of the distributed cumulative histogram are considered. Formulas to reconstruct images of the rotated satellite map images are proposed. The satellite weather map images were taken from the Wunderground services. The clustering algorithm is used to classify the regions of Ukraine by cloudiness intensity, which were created distributed cumulative images. The clustering algorithm is based on the agglomerative procedure.
Between Entrepreneurs and Venture Capitalists

Uncertainty and complexity are fundamental to innovation and decision making, especially in global high technology industries. Entrepreneurs interact with venture capitalists through the entrepreneurs’ communication and learning about the potential of new business venture. We believe that uncertainty and complexity are fundamental to the process of innovation through the synergy between entrepreneurs and venture capitalists. The purpose of this conceptual paper is to provide a conceptual synthesis on a complexity system approach to the innovation relationship between entrepreneurs and venture capitalists.
The Effect of Cumene Hydroperoxide on the cAMP Formation in Opiate-dependent Human SH-SY5Y Cells

The human neuroblastoma SH-SY5Y cells were used to assess the effects of cumene hydroperoxide (CHP) on opioid receptor-mediated changes of intracellular cyclic AMP (cAMP). 10μM morphine acted on SH-SY5Y cells significantly inhibited the stimulatory effect of 1μM forskolin (Fs) which caused an increase in the basal level of intracellular cAMP. However, the inhibitory effect of morphine on cAMP accumulation was significantly attenuated when the cells were pretreated with CHP. Chronic activation of μ-opioid receptors by morphine was shown to lead to partial desensitization, upon withdrawal of the opiate agonist, to overshoot in the production of cAMP in SH-SY5Y cells. But CHP pretreatment reduced the stimulatory effect of Fs on cAMP. The SH-SY5Y cells were treated with different concentrations of CHP for 24h, which indicated that CHP was able to cause oxidative damage in SH-SY5Y cells. MDA contents and ROS levels were increased, SOD activation were reduced. We concluded that the function of μ-opioid receptor was significantly decreased. ROS changed the effects of opioid receptor agonists on intracellular cAMP, which associated with adaptive changes in morphine dependence. Keywords-Opioid receptors; ROS; CHP; cAMP
Review of Repatriation Measures for Foreign Laborers with Pulmonary Tuberculosis in Central Taiwan

According to the regulations in Taiwan, foreign laborers should be repatriated after the diagnosis of pulmonary tuberculosis (TB). The uninterrupted medical care and public health intervention for the repatriated TB patients rely on adequate international collaboration. However, the quality of international referral was rarely evaluated.Foreign laborers with suspected pulmonary TB in central Taiwan reported between July 2009 and February 2012 were enrolled. Demographic data of the referral forms were reviewed and compared with that in the National Notifiable Diseases System (NNDS). The laboratory results, drug resistance profile and medications for TB were recorded. The smear positive rate and culture positive rate were analyzed and compared with those of pulmonary TB patients in Taiwan in 2009.During the study period, 206 foreign laborers were diagnosed with pulmonary TB. Among the 141 cases with referral forms, 28 (19.9%) had consistent demographic records on the referral forms and NNDS. Among the 177 (85.9%) patient who had sputum studies, 23 (11.2%) were smear positive and 65 (31.6%) were culture positive. The smear positive rate and culture positive rate of foreign laborers were both significantly lower than those of pulmonary TB patients in Taiwan in 2009 (p＜0.001). Among the 65 culture positive cases, 5 (7.7%) had mycobacterium isolate resistant to at least one anti-TB medication. Of the 194 foreign laborers who had been repatriated, 57 (29.4%) had been treated with anti-TB drugs for at least 14 days.The inconsistence of demographic data between referral form and NDDS might lead to difficulties in international collaboration. Inadequate anti-TB treatment before repatriation might result in unexpected exposure to TB among other passengers.
IJSRD-International Journal for Scientific Research & Development| Vol. 4, Issue 05, 2016 | ISSN (online): 2321-0613

Vehicular ad hoc networks (VANETs) are a special form of wireless networks which is formed by vehicles which are communicating among themselves on roads. The conventional routing protocols proposed for mobile ad hoc networks (MANETs) are not suitable for VANETS they work poorly in VANETs. As communication links break more frequently in VANETs than in MANETs, the routing reliability of such highly dynamic networks needs to be pay special attention. A very little research has focused on the routing reliability of VANETs on highways. In this paper, we use the evolving graph theory to model the VANET communication graph on a highway. This paper is to propose an evolving graph-based reliable routing scheme for VANETs to provide quality-of-service (QoS) which support in the routing process.
Dressed Elliptic String Solutions on R×S

We obtain classical string solutions on Rt×S2 by applying the dressing method on string solutions with elliptic Pohlmeyer counterparts. This is realized through the use of the simplest possible dressing factor, which possesses just a pair of poles lying on the unit circle. The latter is equivalent to the action of a single Bäcklund transformation on the corresponding sine-Gordon solutions. The obtained dressed elliptic strings present an interesting bifurcation of their qualitative characteristics at a specific value of a modulus of the seed solutions. Finally, an interesting generic feature of the dressed strings, which originates from the form of the simplest dressing factor and not from the specific seed solution, is the fact that they can be considered as drawn by an epicycle of constant radius whose center is running on the seed solution. The radius of the epicycle is directly related to the location of the poles of the dressing factor.
The effects of long lasting physical exercise and training on kidneys functions

During long lasting physical exercise and physical training, a large number of changes occur in the human body. The body homeostasis is disturbed, and observed changes include kidney function. The most common observed symptom is a decrease in the amount of urine excreted due to an increase in the secondary absorption of water during exercise. During long lasting physical exercise the filtration in the glomeruli is impaired, and thus the composition of urine is changing. Differences in the amount of minerals excreted are noted, as a result of water loss, and urine osmolarity increases. Those changes are depend largely on the type of undertaken physical activity, its duration, as well as the individual predisposition of the examined physical active human. Therefore, in individual studies, the results differ significantly, and it is impossible to draw unequivocal conclusions.
Lawrence Berkeley National Laboratory Recent Work Title Representing Processes in the Extended Entity-Relationship Model Permalink

Although closely related, functional and structural aspects of information systems are modeled usually independently of each other. In this paper we propose to combine functional and structural modeling into an integrated design methodology. We choose for this purpose two popular and widely used models, the Data-Flow oriented functional model and the Extended Entity-Relationship (EER) data model. Since functional modeling generally precedes structural modeling in the design of information systems, we examine how functional specifications can be represented using EER constructs. Our methodology is based on using EER existence dependencies for representing the functional constraints implied by the process interactions.
Storm-driven across-shelf oceanic flows into coastal waters

Abstract. The North Atlantic Ocean and northwest European shelf experience intense low-pressure systems during the winter months. The effect of strong winds on shelf circulation and water properties is poorly understood as observations during these episodes are rare, and key flow pathways have been poorly resolved by models up to now. We compare the behaviour of a cross-shelf current in a quiescent period in late summer, with the same current sampled during a stormy period in midwinter, using drogued drifters. Concurrently, high-resolution time series of current speed and salinity from a coastal mooring are analysed. A Lagrangian analysis of modelled particle tracks is used to supplement the observations. Current speeds at 70 m during the summer transit are 10–20 cm s−1, whereas on-shelf flow reaches 60 cm s−1 during the winter storm. The onset of high across-shelf flow is identified in the coastal mooring time series, both as an increase in coastal current speed and as an abrupt increase in salinity from 34.50 to 34.85, which lags the current by 8 d. We interpret this as the wind-driven advection of outer-shelf (near-oceanic) water towards the coastline, which represents a significant change from the coastal water pathways which typically feed the inner shelf. The modelled particle analysis supports this interpretation: particles which terminate in coastal waters are recruited locally during the late summer, but recruitment switches to the outer shelf during the winter storm. We estimate that during intense storm periods, on-shelf transport may be up to 0.48 Sv, but this is near the upper limit of transport based on the multi-year time series of coastal current and salinity. The likelihood of storms capable of producing these effects is much higher during positive North Atlantic Oscillation (NAO) winters.
penelitian tersebut menunjukkan masih relatif rendah bila dibandingkan dengan negara-negara lainnya. Pencapaian tersebut masih banyak berada pada level kemampuan dasar dan belum sampai pada level kemampuan yang lebih tinggi. Pada tahun 2013, hasil PISA untuk siswa Indonesia sangat memprihatinkan yai

This research aimed to determine the effect of learning model on: science process skills in SMA Negeri 1 Langsa. The research applied experimental queasy method research with 3 classes which were using by cluster randome technique. Class A learnt with problem based learning model, class B with guided discovery lerning model, while class C (control) learnt with conventional lerning model. the data analysis technique used Covariat Analysis (ANACOVA) at the level of significance α = 0,05 by using SPSS 21.0. The result showed: there was significant effect of learning models on student’s science process skill (F = 50.953; P = 0.00). student’s science process skill learnt by problem based learning (84.5 ± 5.3) significantly higher than guided discovery (75.30 ± 7.7), and conventional learning models (65.90 ± 8.1).
Deposition and characterization of ZnSnSe2 thin-films deposited by using sintered stoichiometric powder Sinterlenmiş sitokiyometrik toz kullanırak üretilen ZnSnSe2 ince filmlerinin üretimi ve karakterizasyonu

In this work, ZnSnSe2 (ZTSe) thin films were deposited using crystalline powder grown by vertical Bridgman-Stockbarger technique. The deposition process was carried out by means of e-beam evaporation on the well-cleaned soda lime glass substrates and keeping them at the substrate temperature of 200°C. The structural, optical and electrical properties of ternary ZTSe thin films were investigated depending on the annealing temperature at 250 and 300°C. X-ray diffraction analysis showed that as-grown films were in amorphous structure, however annealing at 250°C triggered the crystallization on the preferred ternary structure and annealing at 300°C resulted in the changes from amorphous to the polycrystalline structure. Using the compositional analysis, the detail information about the stoichiometry and the segregation mechanisms of the constituent elements in the structure were determined for both as-grown and annealed samples. In addition, they were morphologically characterized using scanning electron microscopy technique. The electrical properties were analyzed using temperature dependent darkand photo-conductivity measurements. From the variation of electrical conductivity as a function of the ambient temperature, the current transport mechanisms and corresponding activation energies at specific temperature intervals for each sample were determined. The optical properties for the ZTSe thin films were studied depending on the structural changes with annealing.
Thermokarst lake development in syngenetic ice-wedge polygon terrain in the Eastern Canadian Arctic (Bylot Island, Nunavut)

Abstract. Thermokarst lakes are widespread and diverse across permafrost regions and they are considered significant contributors to global greenhouse gas emissions. Paleoenvironmental reconstructions documenting the inception and development of these ecologically important water bodies are generally limited to Pleistocene-age permafrost deposits (Yedoma) of Siberia, Alaska, and the western Canadian Arctic. Here we present the gradual transition from syngenetic ice-wedge polygon terrains to a thermokarst lake in the Eastern Canadian Arctic. We combine geomorphological surveys with paleolimnological reconstructions from sediment cores in an effort to characterize local landscape evolution from terrestrial to freshwater environment. Located on an ice-rich and organic-rich polygonal terrace, the studied lake is now evolving through active thermokarst, as revealed by subsiding and eroding shores, and was likely created by water pooling within a pre-existing topographic depression. Organic sedimentation in the valley started during the mid-Holocene, as documented by the oldest organic debris found at the base of one sediment core and dated at 4.8 kyr BP. Local sedimentation dynamics were initially controlled by fluctuations in wind activity, local moisture and vegetation growth/accumulation, as shown by alternating loess (silt) and peat layers. Fossil diatom assemblages were likewise influenced by local hydro-climatic conditions and reflect a broad range of substrates available in the past (both terrestrial and aquatic). Such conditions likely prevailed until ~ 2000 BP, when peat accumulation stopped as water ponded the surface of degrading ice-wedge polygons, and the basin progressively developed into a thermokarst lake. Interestingly, this happened in the middle of the Neoglacial cooling period, likely under wetter-than-average conditions. Thereafter, the lake continued to develop as evidenced by the dominance of aquatic (both benthic and planktonic) diatom taxa in organic-rich lacustrine muds. Based on these interpretations, we present a four-stage conceptual model of thermokarst lake development during the late Holocene, including some potential future trajectories. Such a model could be applied to other formerly glaciated syngenetic permafrost landscapes.
THE MACROECONOMICS OF IMBALANCE AND ADJUSTMENT

In macroeconomics textbooks, the term 'adjustment' merely describes the diverse, autonomous mechanisms through which macroeconomic equilibrium could be restored when a system is in disequilibrium. But the form in which the term has come to dominate the development economics vocabulary in recent years refers essentially to the policy changes considered necessary to correct for balance of payments disequilibria, defined as arising from inflationary causes.
SOBREVIDA AL PARO CARDIORESPIRATORIO EN LA UNIDAD DE MEDICINA CRÍTICA PEDIÁTRICA

La sobrevida de los pacientes ingresados en una Unidad Terapia Intensiva Pediatrica (UCIP) que sufren un evento de paro cardiorespiratorio (PCR) varia en la literatura de un 6% a 64%. Este estudio busca conocer la sobrevida de los pacientes que presentan un evento de PCR durante su estancia en la UCIP de un hospital publico terciario, las caracteristicas demograficas y factores asociados a estos eventos. Estudio observacional, descriptivo, retrospectivo y transversal. Se revisaron los expedientes de pacientes ingresados en UCIP, durante un ano, que presentaran PCR obteniendo las siguientes variables: edad, genero, dias de estancia, tiempo del ingreso al primer PCR, diagnostico de base, numero de PCR por paciente, RCP basico o avanzado, causa directa del PCR, tiempo transcurrido entre cada uno de los eventos de PCR, el turno, PCR previos al ingreso, uso de aminas, PRISM-12 y 24, evolucion a muerte o sobrevida. 41 pacientes, 74 eventos de PCR, incidencia de PCR 28.8 por 100 admisiones, sobrevida general 80.7%, sobrevida al evento de PCR 48.6%. Estancia 7.4 dias ± 10.6, 5.4 dias del ingreso al PCR, edad media 51 meses, predominio de lactantes, masculinos, diagnostico de ingreso Neurologico, causa del PCR problemas Respiratorios, PCR unico, 60.8% uso de aminas, 94.5% RCP avanzado, PRISM-24 17.4 ± 7.9. Los factores de mal pronostico fueron, menos dias de estancia, primer PCR en las primeras 24 horas del ingreso, presentar nuevo PCR a menos de 24 horas del anterior, y requerir RCP avanzado. Abstract The Overlife of the pacients admitted in a Pediatric Intensive Care Unit (PICU) that suffer an event of cardiacrespiratory heart failure (PCR) changes on the literature from 6% to 64%. This study aims to know the overlife of the pacients that presents an event of PCR during their homesick in the PICU of a tertiary public hospital, the demographic characteristic and factors associated to this events. Observational, descriptive, retrospective and transversal study. The expedients of the pacients admitted on PICU of that year, that presents PCR obtained from the next variables: age, gender, staying days, first admitted PCR date , base diagnostic, number of PCR per pacient, basic or advanced RCP, PCR direct cause, tiem passed from each PCR event, turn, previus PCR events before admitted, aminas use, PRISM-12 and 24, death o overlife evolution. 41 pacients, 74 PCR events, 28.8 per 100 PCR admitted incidence, 80.7% general overlife, 48.6% PCR event overlife. 7.4 dias ± 10.6 staying days, 5.4 days of PCR admitted pacient, 51 months medium age, lactantcy predominance, males, Neurologic admitted diagnostic, respiratory problems cause of the PCR, unique PCR, aminas use 60.8% , 94.5% advanced RCP , PRISM-24 17.4 ± 7.9. The bad pronostic factors were, less staying days, first PCR in first 24 hours admitted, to show new PCR in less than 24 hours of previuos PCR, and require advenced RCP. Palabras clave: UCIP, Paro cardiorespiratorio, sobrevida, PICU (UCIP), cardiac-respiratory heart failure.
Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes

Chronic exposure to arsenic induces a variety of cancers, particularly in the skin. Autophagy is a highly conserved process which plays a dual role in tumorigenesis. In the present study, we found that chronic exposure to an environmentally relevant dose of arsenite induced malignant transformation of human keratinocytes (HaCaT) with dysregulated autophagy as indicated by an increased number of autophagosomes, activation of mTORC1 pathway, and elevated protein levels of p62 and LC3II. Meanwhile, arsenite-transformed cells showed lower intracellular levels of reactive oxygen species compared with control. Silencing p62 ameliorated elevation in mRNA levels of NRF2 downstream genes (AKR1C1 and NQO1) and malignant phenotypes (acquired invasiveness and anchor-independent growth) induced by chronic arsenite exposure. On the other hand, silencing NRF2 abrogated the increase in mRNA and protein levels of p62 and malignant phenotypes induced by arsenite. In response to acute arsenite exposure, impaired autophagic flux with an increase in p62 protein level and interrupted autophagosome-lysosome fusion was observed. The increase in p62 protein levels in response to arsenite was not completely dependent on NRF2 activation and at least partially attributed to protein degradation. Our data indicate that accumulation of p62 by impaired autophagic flux is involved in the activation of NRF2 and contributes to skin tumorigenesis due to chronic arsenite exposure.
Identification of narrow-line Seyfert 1 galaxies in a spurious source sample using spectral line profiles

in English This thesis is a compilation of both general knowledge on galaxies and active galaxies as well as detailed knowledge on NLS1 galaxies. A recent research paper claimed that they confirmed 11001 sources to be NLS1 galaxies. The main object of this thesis was to determine how many of these sources are truly NLS1 with a high certainty. The sources were deemed most likely NLS1 galaxies by studying the emission lines of the galaxy spectra and performing mathematical analysis as well as observing the spectra by eye. After the sources had been either deemed most likely NLS1 or discarded, only 3998 sources remained. The most likely NLS1 galaxy sources were divided into two categories based on their profile type: Lorentzian (Cauchy) or Gaussian. 11 parameters of the most likely NLS1 galaxy sources were further analyzed to find possible differences between the two profile types. With the results of this thesis, researchers can study NLS1 galaxies better by not having a contaminated source sample and can hopefully find instrumental properties of NLS1 galaxies.