Miracle-dz/UniFAR-FTUs huggingface dataset:
Frakturen der Halswirbelsäule bei ankylosierender Spondylitis und diffuser idiopathischer skeletaler Hyperostose

Zusammenfassung Frakturen der Halswirbelsäule bei ankylosierender Spondyilitis oder DISH stellen eine Herausforderung für das perioperative Management dar. Es handelt sich beinahe ausnahmslos um biomechanisch instabile Läsionen des AO-Typs B und C, die gerade infolge von Bagatelltraumen entstehen können. Neurologische Symptome wie auch Verletzungen der hirnversorgenden Gefäße sind häufig. Eine konsequente Schichtbilddiagnostik der gesamten Wirbelsäule gehört zum Goldstandard, um synchrone Verletzungen nicht zu übersehen. Das Patientengut ist per se von einer erhöhten Morbidität und Mortalität gekennzeichnet. So liegt das Prinzip in der konsequenten operativen Stabilisierung, Dekompression und Schaffung einer frühen Rehabilitationsfähigkeit des Patienten. Dies kann durch eine primär dorsale Instrumentierung möglich werden. Eine anteriore Gegenstabilisierung ist im Falle eines ventralen Defektzustandes in Einzelfällen nötig. Bei der DISH ist bei anterioren Fusionsoperationen auf die konsequente Reduktion der ossären Spangen zu achten, um postoperative Dysphagien zu verhindern.
The effect of erythropoietin on alanine aminotransferase during ischemia reperfusion injury in rats

The aim of this experiment study was the erythropoietin testing, on the rat model and particularly on ischemia reperfusion protocol. The benefit or the non effect of that molecule was studied biochemically on blood alanine aminotransferase. Material and methods 40 rats were used of mean weight 247,7 gr. Alanine aminotrans-ferase was measured at these time points: on 60 min after reperfusion (groups A and C), and on 120 min after reperfusion (groups B and D), A and B without but C and D with erythropoietin administration. Results were that 1) erythropoietin administration increased significantly the ALT by 15.2 IU/L [-0.6168546 IU - 31.01685 IU/L] (P= 0.0591), in accordance also with paired t-test (P=0.0480), 2) reperfusion time increased non significantly the ALT by 3.4 IU/L [-13.1482 IU - 19.9482 IU/L] (P= 0.6798), in accordance also with paired t-test (P= 0.5994), and 3) interaction with erythropoietin administration and reperfusion time increased non significantly the ALT levels by 3.581818 IU/L [-6.350404 IU-13.51404 IU/L] (P= 0.4698). Conclusions are that erythropoietin administration, reperfusion time and their interaction have non significant short-term increasing effects on alanine aminotransferase.
Establishing the pig as a large animal model for vaccine development against human cancer

Immunotherapy has increased overall survival of metastatic cancer patients, and cancer antigens are promising vaccine targets. To fulfill the promise, appropriate tailoring of the vaccine formulations to mount in vivo cytotoxic T cell (CTL) responses toward co-delivered cancer antigens is essential. Previous development of therapeutic cancer vaccines has largely been based on studies in mice, and the majority of these candidate vaccines failed to induce therapeutic responses in the subsequent human clinical trials. Given that antigen dose and vaccine volume in pigs are translatable to humans and the porcine immunome is closer related to the human counterpart, we here introduce pigs as a supplementary large animal model for human cancer vaccine development. IDO and RhoC, both important in human cancer development and progression, were used as vaccine targets and 12 pigs were immunized with overlapping 20mer peptides spanning the entire porcine IDO and RhoC sequences formulated in CTL-inducing adjuvants: CAF09, CASAC, Montanide ISA 51 VG, or PBS. Taking advantage of recombinant swine MHC class I molecules (SLAs), the peptide-SLA complex stability was measured for 198 IDO- or RhoC-derived 9-11mer peptides predicted to bind to SLA-1*04:01, −1*07:02, −2*04:01, −2*05:02, and/or −3*04:01. This identified 89 stable (t½ ≥ 0.5 h) peptide-SLA complexes. By IFN-γ release in PBMC cultures we monitored the vaccine-induced peptide-specific CTL responses, and found responses to both IDO- and RhoC-derived peptides across all groups with no adjuvant being superior. These findings support the further use of pigs as a large animal model for vaccine development against human cancer.
A Case of Complete Resealing of Patent Foramen Ovale in a Cloned Red Angus Calf

Case Description: A 56kg (123,2lbs) one-day-old newborn purebred red Angus calf was evaluated because of a cardiac condition. Clinical Findings: Radiography and ultrasonography revealed a loss of continuity of 18mm in the mid intra auricular area, in the region of the oval trench and it was diagnosed as patent foramen ovale. The right auricle was notably distended, with marked volume overload. There were eco dense structures floating inside the left auricle. Treatment and Outcome: Pharmacological treatment aimed to avoid overload of liquid flow in both the lung and the heart. Drugs administered were: furosemide (1mg/Kg every 12h), enalapril (0,5mg/ kg every 12h) and sildenafil (0,5mg/kg every 12h). The goal of using sildenafil was to reduce the preload of the right ventricle and to diminish the risk of right cardiac failure and thus of acute respiratory crisis. Clinical Relevance: Patent foramen ovale is common in newborn cloned calves and probably is under diagnosed in otherwise healthy looking newborn calves. The results of this paper show that foramen ovale can be pharmacologically treated in calves and that euthanasia of newborn animals carrying such pathology must be the last option, only when pharmacological approaches proved non-effective. the umbilical liters Forty mg ofa respiratory stimulants 2ml of 2.5% cefalosporin of 1% clorfenamina maleato [c] 1ml of 10mg/ ketoprofen minutes of life, 1000ml of freshly rehydrated hyper immune colostrum [e] the repeated the completion of during the first four hours of life. After the first umbilical normal foramen II cardiopat
Systemic acquired resistance in tomato againstPhytophthora infestansby pre-inoculation with tobacco necrosis virus☆

Abstract Inoculation of the two bottom leaves (1 and 2) of tomato plants ( Lycopersicon esculentum) cv. Vollendung with tobacco necrosis virus (TNV) induced systemic resistance against late blight disease caused by Phytophthora infestans SDS PAGE of acid soluble proteins extracted from TNV-inoculated plants showed accumulation of six pathogenesis-related proteins in inoculated leaves (1 and 2) and in upper leaf tissue (leaf 3). Western blot analysis with antisera raised against different pathogenesis-related proteins of tomato and tobacco revealed that four of these proteins were P14, AP24, chitinase and β-(1,3)-glucanase. An in vitro study of the antifungal activity of these pathogenesis-related proteins showed that only the basic fraction has direct antifungal activity toward Phytophthora infestans . The induction of systemic resistance was accompanied by an increase of peroxidase activity in inoculated leaves as well as in upper leaf tissue (leaf 3). On the other hand, significant increase in the activity of β-(1,3)-glucanase was observed only in leaves inoculated with tobacco necrosis virus. Leaf tissue analysis of induced plants showed that inoculation with TNV resulted in the induction of three new peroxidase and one β-(1,3)-glucanase isozymes.
Urban-Rural Differences in the Trends of Type 1 and Type 2 Diabetes Among Adults Who Received Medical Treatment from Public Hospitals in Resource-Poor Community Tigray, Ethiopia

Objective This study carried out to describe urban-rural differences in the trend of type 1 and type 2 diabetes among adults who have received medical treatment from public hospitals over the last five years. Methods The trends of adult diabetes assessed from September 1, 2013, to August 31, 2018, using hospital-based retrospective medical records of 299,806 adult patients in the adult medical outpatient and emergency units. Data were collected using a uniform data abstraction format. An extended Mantel-Haenszel chi-square test of the linear trend used to examine the trend over time. Results Of the total 299,806 adult patients, 3056 (1.02% (95% CI: 0.98–1.06)) patients were confirmed diabetes patients. The overall trend in the proportion of diabetes had increased from 6.8 to 14.3 per 1000 adult patients. The trend of type 1 diabetes increased for both urban from 1.0 to 2.2 per 1000 adult urban residents and rural from 1.2 to 2.6 per 1000 adult rural residents, with statistically a significant increase (χ2= 9.1, P=0.002) and (χ2=17.8, P<0.001) for linear trend, respectively. The trend of type 2 diabetes increased for both urban from 6.9 to 14.0 per 1000 adult urban residents and rural from 4.0 to 9.5 per 1000 adult rural residents, with a statistically significant increase (χ2=68.4, P<0.001) and (χ2=74.2, P<0.001) for linear trend, respectively. The higher increase in the proportion of both type 1 and type 2 diabetes observed among women patients. Conclusion The trend in the proportion of type 1 and type 2 diabetes increasing for both urban and rural residents, with a higher increase observed among women. These findings highlight health-care professionals and policymakers to design effective public health policies to treat each type of disease.
A Swollen Leg: Disseminated Tuberculous Pyomyositis After Treatment of Miliary Tuberculosis in an Immunocompromised Patient

Abstract We report a patient with a rheumatic overlap syndrome on hydroxychloroquine and prednisone who developed tuberculous pyomyositis shortly after receiving 9 months of treatment of miliary tuberculosis. Her only presenting symptom was swelling of the left lower extremity without any systemic manifestation, despite extensive radiographic evidence of disseminated abscess formation. Acid-fast bacilli stains and cultures of the purulent material were negative for Mycobacterium tuberculosis (MTB), but polymerase chain reaction confirmed the diagnosis. To our knowledge, this is the first case report of tuberculous pyomyositis that developed shortly after the patient completed a full course of antituberculous therapy. We believe that the concurrent therapy of her rheumatic overlap syndrome with hydroxychloroquine likely led to her treatment failure for MTB and will discuss the possible pathogenesis. Our case also illustrates that MTB can cause significant soft tissue disease without systemic manifestations and that polymerase chain reaction is a valuable diagnostic study.
Growth performance and rhizospheric traits of peach (Prunus persica) in response to mycorrhization on replant versus non-replant soil

Replant disease is considered as a major bottleneck towards improved production of stone fruits such as peach (Prunus persica L. Batsch). Studies were carried out to investigate the effects of inoculation with an arbuscular mycorrhizal fungus (AMF), Funneliformis mosseae on the plant and rhizosphere related parameters on replant versus non-replant soil. In replant soil with AMF treatment, root mycorrhizal colonization was reduced by 48.2% over nonreplant soil. This was well translated through significant decrease in growth attributing characters like plant height, stem diameter, leaf number, and shoot and root dry weight on replant soil, but upon AMF inoculation, a complete reversal of these responses was observed, coupled with an increase in total chlorophyll concentration. Mycorrhizosphere quality indicators, viz. easily extractable glomalin-related soil protein, total glomalin-related soil protein and soil organic carbon concentration were significantly higher in mycorrhizosphere than non-mycorrhizosphere under both replant as well as non-replant soil. These glomalin-related soil proteins in combination with soil organic carbon cemented the water-stable aggregates at 2.00-4.00 and 1.00-2.00 mm size fractions, eventually leading to higher mean weight diameter in mycorrhizosphere. Profiling of soil enzyme activities showed higher catalase and peroxidase activity but lower polyphenol oxidase activity in mycorrhizosphere compared to non-mycorrhizosphere of replant soil. Our results suggested that inoculation with AMF negated the major ill effects of replant disease in peach.
Tobacco use results in inferior outcomes after anatomic total shoulder arthroplasty

Background: This study examined the effect of tobacco use on outcomes of primary anatomic total shoulder arthroplasty (TSA). Methods: A retrospective search identified 59 nonsmokers, 29 former smokers, and 14 current smokers with primary anatomic TSA and at least 2 yr of follow-up. At mean follow-up of 3 yr, patients were assessed with a visual analog scale (VAS), American Shoulder and Elbow Surgeons (ASES), and Single Assessment Numeric Evaluation (SANE) scores and range-of-motion testing. Results: Smokers were significantly younger than nonsmokers or former smokers; there were no other statistically significant differences. VAS scores were significantly higher in current smokers and ASES scores were significantly lower. Complication rates were 36% in current smokers, 15% in nonsmokers, and 7% in former smokers (P = 0.05). Conclusions: Current smokers had significantly worse pain and functional scores and more complications. Former smokers had results similar to nonsmokers, suggesting improved outcomes are possible in patients who quit smoking preoperatively.
Siemens Healthineers - A Risk Assessment

In an increasingly complex world assurance and management control rises up on the agenda with its importance. This work is meant to analyze the existing risks for Siemens Healthineers. In this context COSO ERM integrated framework plays a role. The author concludes that Siemens Healthineer’s risk exposition is quite favorable for the company. Citation: Fiedler FFH-J (2018) Siemens Healthineers A Risk Assessment. J Account Mark 7: 290. doi: 10.4172/2168-9601.1000290
Current trends in drugs avoided in pregnancy

During pregnancy several drugs are having contraindication, hence their use is less and dangerous to mother along with fetus . Drugs play an important role in improving the health and promoting well-being. However to produce desired effect, they have to be safe, efficacious and have to be used rationally. During pregnancy medication is less preferred but in some times cannot be escaped to treat the ailments in mother. Avoiding medications may be desirable, it is often not possible and may be dangerous because some women enter pregnancy medical conditions that require continuous and episodic treatment (e.g. asthma, hypertension, epilepsy). So here we discussed the medication that can be used safely during pregnancy along with unsafe and highly contraindicated for both mother and fetus. Certain drugs given during pregnancy may prove harmful to unborn child is one of the classical problem in the medical treatment. The main purpose of this review is to prepare a list of safe medications which can be taken during pregnancy with unsafe and highly contraindicated drugs. And also a quick reference for health care professionals. Keyboard: Current, Pregnancy, Drugs, Fetus
Diabetes mellitus: An Overview

http://dx.doi. org/10.21276/IJRDPL.22780238. 2018.7(4). 3030-3033 ABSTRACT: Diabetes mellitus is a metabolic disorder resulting from a defect in insulin secretion, insulin action or both. The condition itself introduces a need for patient’s lifestyle adjustment to the disease and a number of everyday therapeutic and diagnostic restrictions. The main indication of diabetes mellitus is a hyperglycemia in blood which is due to inappropriate pancreatic insulin secretion or low insulin-directed fostering of glucose by target cells. It is silent killer disease and affects millions of people in the world. It is estimated that in 2010 there was globally 285 million people suffering from this disease. This number is estimated to increase to 430 million in the absence of better control or cure. Different types of diabetes mellitus, type 1, type 2, gestational diabetes and other types of diabetes mellitus are compared in terms of diagnostic criteria, etiology and genetics. As the disease progresses tissue or vascular damage ensures leading to severe diabetic complications such as retinopathy, neuropathy, nephropathy, cardiovascular complications and ulceration. Currently available pharmacotherapy for the treatment of diabetes mellitus includes insulin and hypoglycemic agents. These drugs act by increasing the secretion of insulin form pancreas or reducing plasma glucose concentrations by increasing glucose uptake and decreasing gluconeogenesis. Comobrid mental diseases can further negatively influence the course of diabetes. They are specially depression, anxiety disorders, eating disorders and cognitive disorders including dementia. Various herbal drugs have been also proved effective due to their beneficial contents in treatment of diabetes. This article focuses on the causes, types, diagnosis and treatment of diabetes.
Association between obesity and perceived halitosis in Korean adolescents

Adolescent obesity is a growing problem, which is related to serious medical diseases, including poor oral health. Halitosis is an important part of oral health. Therefore, the present study aimed to examine the association between perceived halitosis and obesity in Korean adolescents. The present study used data from the 2015 Korea Youth Risk Behavior Web-based Survey in analyzing 68,043 Korean adolescents aged 12–18. The dependent variables, perceived halitosis, and socioeconomic variables, health-related variables, and oral health-related variables, were collected by using self-administered questionnaires. A multiple logistic regression analysis was used to evaluate the association between obesity and perceived halitosis while controlling for school type, city scale, economic status, education levels of parents, academic achievement, stress, physical activity, drinking, smoking, taking frequencies of fast foods, soda, and fruits, tooth brushing frequency, and interdental cleaning. In the descriptive analysis, adolescents with a low socioeconomic status were more likely to be obese and perceived higher halitosis. In addition, perceived halitosis was associated with low physical activity, high stress, and low tooth brushing frequency. After adjusting for confounders, there was a significant association between obesity and perceived halitosis [odds ratio (95% Confidence Interval (CI)) : 1.22 (1.06-1.42)]. Odds ratio (OR) of girls was 1.60 (95% CI : 1.17-2.20) and OR of boys was 1.15 (95% CI : 0.98-1.35). This study demonstrates that obesity is closely associated with perceived halitosis in Korean adolescents. Therefore, intervention programs are required to prevent obesity and malodors for adolescents on a national scale.
Comparison of Different Dynamic Contrast Enhanced-Magnetic Resonance Imaging Descriptors and Clinical Findings Among Breast Cancer Subtypes Determined Based on Molecular Assessment

Background: Breast cancer is a heterogeneous disease with different molecular and histologic subtypes, clinical behaviors and prognosis. The same stage of disease and similar histopathological characteristics may show different treatment responses. Identification of breast cancer subtypes has become important for planning the targeted therapy and personalized management of patients. Objectives: To compare the clinicopathologic findings, dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) characteristics and associated MRI findings among breast cancer molecular subtypes. Patients and Methods: 267 pathologically proven invasive breast cancers in 263 patients were included. Clinicopathological findings, DCE-MRI findings and associated MRI findings were retrospectively evaluated and compared among breast cancer subtypes. Results: Invasive ductal carcinoma was the most common histological tumor type (87.6%). There were 222 (83.1%) masses and 45 (16.9%) non-mass enhancements. The molecular subtypes were luminal A in 174 (65.1%), luminal B in 45 (16.9%), human epidermal growth factor receptor 2 (HER2) positive in 24 (9%) and triple negative (TN) in 24 (9%) of the lesions. Spiculated mass margin was significantly associated with luminal A breast cancer (45.2%) and irregular shape was significantly more common in luminal A (86.3%) and luminal B lesions (95.1%) (P < 0.001). Larger mass size (P = 0.027), non-mass enhancement (P = 0.005), perilesional + prepectoral edema and skin + perilesional + prepectoral edema were significantly associated with HER2 positive breast cancer (P = 0.001). Higher histological grade, oval mass shape, circumscribed mass margin, intratumoral high/very high signal intensity on T2 weighted image (T2WI) were significantly associated with TN breast cancer (P < 0.001). Conclusion: Histological grade, size and morphological features of masses on DCE-MRI, intratumoral signal intensity on T2WI and edema pattern would be helpful to distinguish breast cancer subtypes.
A Feature-based Approach for Identifying Soccer Moves using an Accelerometer Sensor

: During the past decade, Human Activity Recognition (HAR) systems have been an evolving topic due to the popularity of smart devices. Recognizing soccer moves in real-time is an important research problem that has not yet been studied thoroughly in the literature. In contrast to daily physical activities, recognizing soccer moves poses a set of unique challenges, such as pattern irregularity and body positions when performing these moves. In this paper, our goal is to recognize soccer moves in real-time by utilizing accelerometer data. We explore three different feature-based algorithms: Time Series Forest, Fast Shapelets, and Bag-of-SFA-Symbols. We also examine different factors that can affect the performance of these algorithms, such as parameter tuning and accelerometer axis elimination. Additionally, we introduce a novel collaborative model consisting of the above-mentioned algorithms in a majority voting mechanism to further enhance the performance of the system. We also add a light-weight classiﬁer to act as a tie breaker in case of disagreement between the classiﬁers. We experimentally choose the right parameters to reduce the training time drastically without forfeiting the level of accuracy. Our collaborative model outperforms the single model by 2% to reach 84% in accuracy with a decrease in the training time by one order of magnitude.
Carboidratos na dieta pr-inicial de frangos de corte

This work was conducted to determine the N-corrected apparent metabolizable energy (EMAn) of different carbohydrate sources for broilers from 1 to 7 days, and to evaluate the utilization of these ingredients in the diet of newly hatched broilers based and on live performance and on the gastrointestinal tract (TGI) development. Total excreta collection method was used in trial one, with 220 male chicks from 4 to 7 days, allocated to batteries in a completely randomized design with five treatments (a reference diet and four diets with inclusion of 20% of the test ingredients) and four replicates of 11 birds. The ingredients evaluated were corn starch (AMI), cassava starch (AMA), glucose (GLI) and sucrose (SAC). In Trial 2, 520 day-old male chicks were allotted to a completely randomized design with five treatments and four replicates of 26 birds. The birds received the treatments (1 - corn and soybean meal diet, 2 - corn and soybean meal diet + AMI, 3 - corn and soybean meal diet + AMA, 4 - corn and soybean meal diet + GLI, 5 - corn and soybean meal diet + SAC) only from 1 to 7 days. From 8 to 21 days, all the birds received a standard diet. The EMAn values of the ingredients determined for broilers in the first week were 3,269; 3,690; 3,427 and 3,524 kcal/kg for AMI, AMA, GLI and SAC, respectively. In general, the results showed that the treatments did not affect the TGI development, but feed intake was improved by the more available carbohydrate sources in the newly hatched chicks diets, contributing to a higher liveweight of the birds.