Miracle-dz/UniFAR-FTUs huggingface dataset:
Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis

Background Acetaminophen is commonly used for the relief of pain and fever. Advocacy organizations recommend acetaminophen as the drug of choice in patients with kidney disease. Although some studies have suggested a risk of renal impairment after the use of acetaminophen, the effect of acetaminophen on the risk of renal impairment is unclear. The purpose of this research was to demonstrate any correlation linking acetaminophen treatment and renal impairment. Methods We performed a systematic review and meta-analysis of the association between acetaminophen and renal impairment in adults by searching Cochrane Library, PubMed, and Embase databases from initiation to June 16, 2019. Results Of 13,097 articles identified, 5 studies (2 cohort studies and 3 case-control studies) with a total of 13,114 participants were included. In the random-effects meta-analysis of the cohort study, acetaminophen use was shown to have statistically significant effects on the increased risk of renal impairment (adjusted odds ratio 1.23; 95% confidence interval, 1.07-1.40). The results of sensitivity and subgroup analyses also suggested that acetaminophen use increases the risk of renal impairment. The Egger’s test (P = 0.607) and Begg’s test (P = 0.732) revealed no apparent publication bias. Conclusion Acetaminophen is associated with a significantly increased risk of newly developing renal impairment in adults. Physicians who prescribe acetaminophen should be aware of potential adverse renal effects. A longitudinal study that further explores this association is warranted.
Variations in Cadmium Concentrations in Rice and Oxidation-Reduction Potential at the Soil Surface with Supplementation of Fermented Botanical Waste-based Amendment in Large-scale Farmland

We monitored the relationship between the cadmium (Cd) concentration uptake of rice and the oxidation-reduction potential (ORP) at the soil surface with the supplementation of fermented botanical waste-based amendment (FBWA), an organic fertilizer prepared from woody and food wastes. This study was carried out for 3 years in the western part of Jiangsu Province, China. It was found that the Cd concentration taken up by rice was correlated to a decreased the ORP of the cultivated soil. The yield of rice was ῀1.20 times higher than that of the control plot. The effects of reducing the Cd content in rice and increasing the rice yield remained for 2 years after FBWA application. Finally, Cd was immobilized in the soil with adsorption to FBWA or the decomposed products. The ORP measurement during rice cultivation might be a key index to predict the suppression effect of Cd uptake into the rice or limitation of the sustainable effect by the FBWA.
Perineal Laceration and Episiotomy Repair Using a Beef Tongue Model

Introduction Declining rates of operative vaginal deliveries and routine episiotomy in obstetric practice, along with rising cesarean section rates, have decreased OB/GYN resident experience with episiotomy repair and obstetric anal sphincter injuries (OASIS). Simulation models are valuable educational tools in procedural training. Several models have been reported, each with its own limitations and benefits. Methods We developed a 1-hour workshop to teach novice OB/GYN residents perineal laceration repair skills on a modified beef tongue model. The model required 5–10 minutes to assemble following written and video instruction, and learners had 30–50 minutes to practice using learner instructions. Learners were evaluated using a procedure checklist and global objective structured assessment of technical skills. To evaluate the session, we surveyed current faculty and residents, as well as residency graduates. Results Between 2008 and 2017, an estimated 82 OB/GYN residents participated in this activity, and 95 participants and facilitators received the survey. Forty-one (59%) respondents agreed that this model was similar to repairing OASIS in clinical practice. Our trainees reported that the optimal time for simulated OASIS repair was the R2 and R3 years; however, 90% of respondents felt residents should be offered this simulation yearly. Discussion Based on our survey of trainees, graduates, and faculty, we created a realistic simulated OASIS repair training, despite the limitation that the model lacked a rectum. Learners reported an interest in repeating the simulation frequently during residency to augment their clinical experience and increase perceived competence in third- and fourth-degree laceration repair by their graduation.
Performance of prognostic markers in the prediction of wound healing or amputation among patients with foot ulcers in diabetes: A systematic review

Clinical outcomes of patients with diabetes, foot ulceration, and peripheral artery disease (PAD) are difficult to predict. The prediction of important clinical outcomes, such as wound healing and major amputation, would be a valuable tool to help guide management and target interventions for limb salvage. Despite the existence of a number of classification tools, no consensus exists as to the most useful bedside tests with which to predict outcome. We here present an updated systematic review from the International Working Group of the Diabetic Foot, comprising 15 studies published between 1980 and 2018 describing almost 6800 patients with diabetes and foot ulceration. Clinical examination findings as well as six non‐invasive bedside tests were evaluated for their ability to predict wound healing and amputation. The most useful tests to inform on the probability of healing were skin perfusion pressure ≥ 40 mmHg, toe pressure ≥ 30 mmHg, or TcPO2 ≥ 25 mmHg. With these thresholds, all of these tests increased the probability of healing by greater than 25% in at least one study. To predict major amputation, the most useful tests were ankle pressure < 50 mmHg, ABI < 0.5, toe pressure < 30 mmHg, and TcPO2 < 25 mmHg, which increased the probability of major amputation by greater than 25%. These indicative values may be used as a guide when deciding which patients are at highest risk for poor outcomes and should therefore be evaluated for revascularization at an early stage. However, this should always be considered within the wider context of important co‐existing factors such as infection, wound characteristics, and other comorbidities.
Characteristics of Focal Gamma Zone Parapapillary Atrophy

Purpose The purpose of this study was to investigate the characteristics of focal γ-zone parapapillary atrophy (focal γPPA) in patients with primary open-angle glaucoma (POAG) using spectral-domain optical coherence tomography (SD-OCT). Methods Three groups of POAG eyes (n = 214) were defined according to the circumferential extent of Bruch's membrane (BM) within the β-zone PPA, as follows: (1) no γPPA (intact BM; n = 81), (2) conventional γPPA (γPPA involving the fovea-BM-opening axis; n = 89), and (3) focal γPPA (γPPA not involving the fovea-BM-opening axis; n = 44). Clinical and ocular characteristics, including age, axial length (AXL), and focal lamina cribrosa (LC) defects were compared among the three groups. Results The focal γPPA group was significantly older (60.6 ± 11.0 years) and had shorter AXL (24.10 ± 1.34 mm) than those of the conventional γPPA group (46.2 ± 13.8 years and 26.53 ± 1.61 mm, respectively; P < 0.001). These values of the focal γPPA group were similar to those of the no γPPA group (23.73 ± 0.97 mm for AXL and 64.0 ± 13.0 years for age). The focal γPPA group had a significantly higher prevalence of focal LC defects than did the other two groups (70.5% [31/44] for the focal γPPA group versus 46.1% [41/89] for the conventional γPPA group versus 37.0% [30/81] for the no γPPA group; P = 0.002). Conclusions Focal γPPA was differentiated from conventional γPPA by older age and shorter AXL. Further, focal γPPA was frequently accompanied by focal LC defects. Longitudinal studies elucidating whether focal LC defects and focal γPPA share common pathogenesis are warranted.
Molecular docking, DFT and antimicrobial studies of Cu(II) complex as topoisomerase I inhibitor

Abstract Herein, we report the synthesis and single crystal X-ray structure of Cu(II)-picolinic acid complex, 1 as a potent topoisomerase I inhibitor. The complex 1 crystallized in the triclinic crystal system with space group P-1. Comparative in vitro binding studies of complex 1 with CT DNA and tRNA were carried out revealing an electrostatic binding mode with higher binding propensity towards tRNA. The intrinsic bonding constant value, K b was calculated to be 4.36 × 104 and 8.78 × 104 M−1 with CT DNA and tRNA respectively. DNA cleavage activity was carried out with a pBR322 plasmid DNA substrate to ascertain the cleaving ability. Furthermore, Topo-I inhibition assay of complex 1, performed via gel electrophoresis revealed a significant inhibitory effect on the enzyme catalytic activity at a minimum concentration of 15 µM. The DFT studies were carried out to provide better insight in the electronic transitions observed in the absorption spectrum of the complex 1. Molecular docking studies were carried out with DNA, RNA and Topo-I to determine the specific binding preferences at the target site and complement the spectroscopic studies. The antimicrobial potential of complex 1 was screened against E. coli, S. aureus, P. aeruginosa, B. subtilis and C. albicans; and compared with doxycycline, exhibiting an excellent maximum zone of inhibition of 28 mm against E. coli. Communicated by Ramaswamy H. Sarma
Apatinib combined with chemotherapy or concurrent chemo-brachytherapy in patients with recurrent or advanced cervical cancer

Abstract Objective: Apatinib mesylate is a novel vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitor, which has exhibited good safety and efficacy in several types of solid tumors. The present study aimed to assess the clinical efficacy and safety of apatinib combined with chemotherapy and concurrent chemo-brachytherapy (CCBT) in patients with recurrent and advanced cervical cancer. Methods: A total of 52 patients with first diagnosed recurrent or untreated International Federation of Gynecology and Obstetrics stage IVB cervical cancer admitted at Shandong Cancer Hospital and Institute between July 2016 and May 2018 were analyzed in the current randomized controlled trial. The patients were randomly divided into 2 groups: the apatinib-treated group and the control group. Patients with recurrent cervical cancer in the apatinib-treated group were administered apatinib and carboplatin-paclitaxel as first-line chemotherapy. Patients with advanced cervical cancer were administered apatinib in combination with CCBT. In control group, patients with recurrent cervical cancer were treated with chemotherapy alone while patients with advanced cervical cancer received CCBT. Results: The progression-free survival was significantly prolonged in apatinib group compared with control group (10.1 months; 95% confidence interval (CI), 8.42–11.79 vs 6.4 months; 95% CI, 3.88–8.92; P < . 01; hazard ratio (HR), 0.44; 95% CI, 0.25–0.78; P < . 01). The objective response rate in apatinib group was obviously higher than that in control group (64.3% vs 33.3%, P < .05). Proteinuria, hand–foot syndrome, mucositis, and hypertension in all Grades were statistically more common in apatinib group than in control group. Apatinib did not obviously aggravate other radiotherapy or chemotherapy side effects. Conclusion: Apatinib exhibited promising clinical efficacy in cervical cancer patients, resulting in an improved response rate and prolonged progression-free survival compared with the control group, and had manageable side effects. Our study revealed that apatinib combination therapy, adenocarcinoma, and bone metastasis
The Relationship of Shoulder and Elbow Stresses and Upper Limb Contact Order During a Round‐Off Back Handspring

Despite high injury incidence rates in gymnastics, there is a paucity of data characterizing upper extremity injury causation and biomechanical risk factors. This study investigated contact forces across multiple joints in both upper extremities during a round‐off back handspring (ROBHS), a fundamental gymnastics tumbling maneuver.
Frailty index as a clinical measure of biological age in psychiatry

The concepts of “accelerated biological ageing” and “premature biological senescence” have been receiving increasing attention in relation to psychiatric diseases, with clinical, epidemiological and molecular observations suggesting that psychopathological processes can have significant relationships with aging-related phenomena. The deficit accumulation model postulates that the individual’s biological age and functional status is related to the amount of health deficits accumulated over time and that one’s biological age can be estimated by summarizing health deficits in a single continuous variable, the so-called “frailty index” (FI). In this presentation it will be discussed the possibility that the FI, which condenses information arising from multidimensional evaluations, represents a potential clinically-useful macroscopic indicator of biological age which can add relevant information to the measurements currently implemented in the study of accelerated biological age in psychiatric diseases. Disclosure No significant relationships.
Comparison between type A and type B early adiposity rebound in predicting overweight and obesity in children: a longitudinal study

Abstract Early adiposity rebound (EAR) predicts paediatric overweight/obesity, but current approaches do not consider both the starting point of EAR and the BMI trajectory. We compared the clinical characteristics at birth, age 3–5 and 6–8 years of children, according to the EAR and to its type (type A/type B-EAR). We assessed the childrenʼs odds of being classified as overweight/obese at age 6–8 years, according to the type of EAR as defined at age 3–5 years. As part of this two-wave observational study, 1055 children were recruited and examined at age 3–5 years. Antenatal and postnatal information was collected through interviews with parents, and weight and height from the health records. Type A and type B-EAR were defined in wave 1 according to the BMI nadir and the variation of BMI z-score between the starting point of the adiposity rebound and the last point on the curve. At 6–8 years (wave 2), 867 children were followed up; 426 (40·4 %) children demonstrated EAR. Among them, 172 had type A-EAR, higher rates of parental obesity (P < 0·05) and greater birth weight compared with other children (P < 0·001). Odds for overweight/obesity at 6–8 years, when adjusting for antenatal and postnatal factors, was 21·35 (95 % CI 10·94, 41·66) in type A-EAR children and not significant in type B-EAR children (OR 1·76; 95 % CI 0·84, 3·68) compared with children without EAR. Classification of EAR into two subtypes provides physicians with a reliable approach to identify children at risk for overweight/obesity before the age of 5 years.
A novel EDA1 missense mutation in X-linked hypohidrotic ectodermal dysplasia

Abstract A mutation in the epithelial morphogen gene ectodysplasin-A1 (EDA1) is responsible for the disorder X-linked hypohidrotic ectodermal dysplasia (XLHED), the most common form of ectodermal dysplasia. XLHED is characterized by impaired development of hair, eccrine sweat glands, and teeth. This study aimed to identify potentially pathogenic mutations in four Chinese XLHED families. Genomic DNA was extracted from the peripheral blood and sequenced. Sanger sequencing was used to carry out mutational analysis of the EDA1 gene, and the three-dimensional structure of the novel mutant residues in the EDA trimer was determined. Transcriptional activity of NF-κB was tested by Dual luciferin assay. We identified a novel EDA1 mutation (c.1046C>T) and detected 3 other previously-reported mutations (c.146T>A; c.457C>T; c.467G>A). Our findings demonstrated that novel mutation c.1046C>T (p.A349 V) resulted in XLHED. The novel mutation could cause volume repulsion in the protein due to enlargement of the amino acid side chain. Dual luciferase assay revealed that transcriptional NF-κB activation induced by XLHED EDA1 protein was significantly reduced compared with wild-type EDA1. These results extend the spectrum of EDA1 mutations in XLHED patients and suggest a functional role of the novel mutation in XLHED.
The Significance of Knowledge Management in Civil Engineering Construction Firms in Nigeria

The knowledge generated during the construction phase of the projects are loss as results of lack of awareness of the benefits derived in knowledge management (KM) practice by the professionals of the civil engineering (CE) construction firms. Therefore, the paper evaluates the significance of KM practice in the CE construction companies. The research methodology adopted was the questionnaire survey approach as a result of complexity, fragmentation and diversification of CE construction companies. A total of three hundred (350) numbers of questionnaires were distributed to Engineers, Quantity surveyors, Architect, Foreman, along with other employees across the participated CE construction companies. The descriptive and T-test analysis were employed to analyze the data obtained from the respondents. The results show that the KM practice improves the construction organizational performance in terms of project delivery, reduce construction reworks, improve problems solving solutions and decision making etc. The paper suggests that the CE construction companies should develop proactive management strategies that facilitate the practice of KM. In addition there is a need to create awareness of the benefits of KM practice in the CE construction companies through workshops, seminars and mentoring and coaching.
Search of prognostic biomarkers in patients with multiple sclerosis

El objetivo de esta tesis ha sido la identificacion de biomarcadores pronosticos en la esclerosis multiple (EM), principalmente biomarcadores de actividad de la enfermedad y biomarcadores de respuesta al tratamiento con interferon beta (IFNs). Los resultados expuestos en esta tesis muestran un incremento en la expresion del gen ? sialic acid binding Ig-like lectins 1? (SIGLEC1) en fases progresivas de la EM (principalmente en pacientes con EM primariamente progresiva - EMPP). Un analisis mas detallado demostro que tanto los monocitos residentes como los inflamatorios contribuyeron al incremento de la expresion de SIGLEC1 en pacientes con EMPP. Tambien observamos que la expresion de SIGLEC7 se encuentro aumentada en la EM recurrente-remitente (EMRR) durante el brote. Nuestros resultados tambien mostraron una expresion deficiente del gen ? ubiquitin specific peptidase 18? (USP18) en pacientes con EMRR comparado con controles. Experimentos adicionales mostraron que los pacientes portadores del haplotipo CG presentaron niveles de expresion del gen USP18 disminuidos y un incremento en la actividad clinica de la enfermedad en comparacion con los no portadores del haplotipo CG. Ademas, los pacientes homocigotos AA para un polimorfismo intronico del gen USP18 presentaron una buena respuesta al tratamiento con IFNs. En conclusion, nuestros resultados sugieren la implicacion de SIGLEC1 en la fase cronica progresiva de la EM, y un papel de SIGLEC7 en la actividad aguda de la enfermedad. Tambien sugieren la implicacion de USP18 en la patogenia de la EM y la respuesta terapeutica al IFNs. En base a estos resultados, proponemos SIGLEC1, SIGLEC7 y USP18 como biomarcadores de actividad de la enfermedad, y USP18 como biomarcador de respuesta al IFNs.
Benefits of Using Plant Extracts in Fertility Preservation with Special Reference to Moringa Oleifera

Due to the increase in childhood cancer survivors,fertility preservation has become an important issue in the field of cancer management and infertility treatment. However, the limitations of current methods such as semen cryopreservation, testicular tissue cryopreservation,and in vitro spermatogenesis, urges the researchers to explore alternative and practically feasible approaches to protect the gonadal tissue from the cytotoxic chemotherapeutic agents. This review highlights the possible application of natural products, especially the Moringa oleifera leaf extracts in protecting the gonadal tissue from cytotoxic agents, their possible mechanism of action, advantages, current situation and scope for future research.
Investigation of JC Polyomavirus (JCV) Genome in Colorectal Cancer Patients from Iran

1. Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran 2. The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 3. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran 4. Department of Virology, Pasteur Institute of Iran, Tehran, Iran 5. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
EMERGING TRENDS IN GEOSPATIAL TECHNOLOGIES FOR STUDY OF URBAN LANDSCAPE

reflect the official position of the Council of Educators in Landscape Architecture (CELA), and its printing and distribution does not constitute an endorsement of views which may be expressed. Citation of this work should state that it is from a CELA conference paper. EXAMPLE: Author's Last Name, Initials. 2018. Title of Paper. Blacksburg, Virginia: CELA. For information about securing permission to reprint or reproduce this paper, please contact CELA at staff@thecela.org EMERGING TRENDS IN GEOSPATIAL TECHNOLOGIES FOR STUDY OF URBAN LANDSCAPE
Struktúrafüggetlen címzésen alapuló önszervezôdô útvonalválasztási architektúra

Az Internet történetét ismerôk elôtt nem titok, hogy a manapság nélkülözhetetlen hálózat, mely felhasználók milliárdjait kapcsolja össze, nem tudatos, elôrelátó tervezés eredménye. Ennek következtében ma több olyan problémával, jelenséggel küzd, melyek egyre nehézkesebbé teszik mind az útvonalválasztást, mind pedig a hálózatmenedzsmentet (pl. multihoming, mobilitás) [1]. Ennek oka számos szakember szerint az Internet hierarchikus felépítésében keresendô, vagyis abban, hogy az IP-címek integrált információként tartalmazzák egy csomópont helyét és azonosítóját. A megoldás pedig egy szemléletváltás volna, mely olyan címzési rendszert vezetne be, ahol hely és azonosító különválna egymástól (flat címzés). Ezzel a megközelítéssel hosszútávon elôre tervezhetôvé s egyszerûbbé tehetô a kommunikáció. Az 1. ábrán példaként a mobilitás jelensége látható hierarchikus és flat típusú címek esetén. Az egyetlen akadály a flat routing felé vezetô úton, hogy a jelenlegi útvonalválasztó algoritmusok nem képesek hatékonyan kezelni az ilyen jellegû címeket. A cél tehát egy olyan útvonalválasztási algoritmus kidolgozása, mely struktúrafüggetlen azonosítók esetén is hatékony mûködésre képes. Több olyan kezdeményezés is született, mely erre a problémára próbál megoldást nyújtani (HIP, FARA, TRIAD, IPNL, i3 stb. [3-7]), amelyek a név és hely különválasztását ugyan megvalósítják, de továbbra is szükség van névfeloldásra (DNS), mely aztán a neveket átfordítja hálózati helyet jelzô címekre. Így tehát a hálózat egésze mégsem struktúrafüggetlen, vagyis az útvonalválasztás skálázódása továbbra is függ a hálózat felépítésétôl. Fentiektôl eltérô megoldást jelentenek a ROFL[8] és VRR[9] útvonalválasztási sémák, melyek a struktúrafüggetlenséget egy DHT-gyûrû alkalmazásával teszik lehetôvé. A hatékonyság érdekében viszont folyamatosan fent kell tartani a DHT-gyûrût. A ROFL esetén a routerek cache-elik a kiépített útvonalakat, ami ugyancsak menedzselést igényel, a VRR-t pedig csak kisméretû hálózatokra tesztelték[9]. A jelen cikkben egy teljesen újfajta megközelítést szeretnénk bemutatni, mely egy igen egyszerû ötleten, illetve az Internet és a közösségi hálózatok hasonlóságán alapulva próbál alternatívát kínálni a ma létezô megoldások helyett. A 2. szakaszban röviden bemutatjuk a kidolgozott útvonalválasztási algoritmus alapötletét. A 3. szakaszban a megvalósítás lépéseit vesszük sorra, a 4. szakasz pedig a szimulációs eredményeket tárgyalja, végül a cikk összefoglalással zárul.