Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiorespiratory Fitness, Adiposity, and Cardiometabolic Risk Factors in Schoolchildren: The FUPRECOL Study

The aim of this study was to investigate the association between cardiorespiratory fitness (CRF) and cardiovascular risk factors (CVRF) in schoolchildren. A secondary aim was to evaluate the degree of association between overall and abdominal adiposity and CRF in a total of 1,875 children and adolescents attending public schools. We expressed CRF performance as the nearest stage (minute) completed and the estimated peak oxygen consumption. A CVRF (Z score) was calculated and participants were divided into tertiles according to low and high levels of overall (sum of the skinfold thicknesses) and abdominal adiposity. Schoolchildren with a high-level of overall adiposity demonstrated significant differences in seven of the 10 variables analyzed (i.e., systolic and diastolic blood pressure, triglycerides, triglycerides/high density lipoproteins [HDL-c] ratio, total cholesterol, glucose, C-reactive protein [usCRP], HDL-c, low density lipoproteins [LDL-c], and cardiovascular risk score). Schoolchildren with high levels of both overall and abdominal adiposity and low CRF had the least favorable CVRF score.
Effect of the absolute statistic on gene-sampling gene-set analysis methods

Gene-set enrichment analysis and its modified versions have commonly been used for identifying altered functions or pathways in disease from microarray data. In particular, the simple gene-sampling gene-set analysis methods have been heavily used for datasets with only a few sample replicates. The biggest problem with this approach is the highly inflated false-positive rate. In this paper, the effect of absolute gene statistic on gene-sampling gene-set analysis methods is systematically investigated. Thus far, the absolute gene statistic has merely been regarded as a supplementary method for capturing the bidirectional changes in each gene set. Here, it is shown that incorporating the absolute gene statistic in gene-sampling gene-set analysis substantially reduces the false-positive rate and improves the overall discriminatory ability. Its effect was investigated by power, false-positive rate, and receiver operating curve for a number of simulated and real datasets. The performances of gene-set analysis methods in one-tailed (genome-wide association study) and two-tailed (gene expression data) tests were also compared and discussed.
Acetylcholine‐induced neuronal differentiation: muscarinic receptor activation regulates EGR‐1 and REST expression in neuroblastoma cells

Neurotransmitters are considered part of the signaling system active in nervous system development and we have previously reported that acetylcholine (ACh) is capable of enhancing neuronal differentiation in cultures of sensory neurons and N18TG2 neuroblastoma cells. To study the mechanism of ACh action, in this study, we demonstrate the ability of choline acetyltransferase‐transfected N18TG2 clones (e.g. 2/4 clone) to release ACh. Analysis of muscarinic receptors showed the presence of M1–M4 subtypes and the activation of both IP3 and cAMP signal transduction pathways. Muscarinic receptor activation increases early growth response factor‐1 (EGR‐1) levels and treatments with agonists, antagonists, and signal transduction enzyme inhibitors suggest a role for M3 subtype in EGR‐1 induction. The role of EGR‐1 in the enhancement of differentiation was investigated transfecting in N18TG2 cells a construct for EGR‐1. EGR‐1 clones show increased neurite extension and a decrease in Repressor Element‐1 silencing transcription factor (REST) expression: both these features have also been observed for the 2/4 clone. Transfection of this latter with EGR zinc‐finger domain, a dominant negative inhibitor of EGR‐1 action, increases REST expression, and decreases fiber outgrowth. The data reported suggest that progression of the clone 2/4 in the developmental program is dependent on ACh release and the ensuing activation of muscarinic receptors, which in turn modulate the level of EGR‐1 and REST transcription factors.
Property Rights and the Evolution of a Frontier

As a frontier closes land goes from a state where land values are low and property rights undefined, to a state where values have risen and tenure has become secure. Along this evolution the incentives for settlers to invest in productive activities and to expend resources to stake and enforce their claims will change. This dynamic nature of frontier settlement is modeled with special attention to the role of property rights. A simulation of the optimal paths of the control and state variables which emerge from the model is used to analyze the phenomenon of frequent land sales by settlers.
Pulmonary function one and four years after a deep saturation dive.

The pulmonary function of 24 Norwegian divers who had participated in a deep saturation dive to pressures of 3.1-4.6 MPa was reevaluated one and four years later. Twenty-eight divers performing ordinary saturation diving to pressures of 0.8-1.6 MPa and followed over a three-year period served as referents. A significant reduction in forced expiratory volume in 1 s (FEV1.0) of 210 (SD 84) ml (P < 0.001) occurred the first year after the dive. Thereafter the annual reduction in FEV1.0 was 28 (SD 62) ml.year-1; this value did not differ from the 35 (SD 80) ml.year-1 of the referents. The forced midexpiratory flow rate and forced expiratory flow rates at low lung volumes were also significantly reduced one year after the deep dive, and the closing volume was increased. No significant changes occurred in forced vital capacity. The results agree with those of cross-sectional studies on divers' lung function and indicate the development of airflow limitation in relation to diving exposure.
Endothelium-dependent vasodilation in the uvea of hypertensive and normotensive rats.

PURPOSE The effects of endothelium-related substances such as acetylcholine, a stimulator of endogenous NO-production, the NO-synthesis inhibitor L-NMMA, the exogenous NO-donor sodium nitroprusside and the endothelin (ET)A-receptor antagonist BQ123, on uveal blood flow were investigated in normotensive and hypertensive SHR rats. METHOD The radioactively-labelled microsphere method was applied for the measurement of regional blood flow in the uvea. RESULTS Under resting conditions, local blood flow was lower in the hypertensive animals. The increase in choroidal blood flow (145 +/- 50%; P < 0.01) and reduction in vascular resistance (-58 +/- 7%; P < 0.01) observed in the WKY after i.v. infusion of acetylcholine, 2 micrograms x kg bw-1 x min-1, were significantly less pronounced in animals pretreated with L-NMMA, indicating local formation of NO as a vasodilator mechanism. In contrast, acetylcholine did not induce significant vasodilation in the choroid of SHR rats. In the anterior uvea of both strains, acetylcholine did not affect local blood flow. L-NMMA, 20 mg x kg bw-1, alone reduced blood flow in the entire uvea of both strains. Intravenous injection of BQ123, 1 mg x kg bw-1, did not affect regional blood flow in the uvea of WKY or SHR animals. Infusion of acetylcholine following ETA-receptor blockade induced vasodilation in both the choroid and anterior uvea in the WKY but not in the SHR. CONCLUSIONS Acetylcholine-stimulated NO-mediated vasodilation, but not basal NO-formation, was impaired in the choroid of the SHR. Furthermore, an interaction between vasoconstricting ET and acetylcholine was found in the anterior uvea of normotensive but not hypertensive rats.
An Orthogonal Series Expansions Method to Hedge and Price European-Type Options

Closed-form pricing formulae and option Greeks are obtained for European-type options using an orthogonal polynomial series--complex Fourier series. We assume that risky assets are driven by exponential L\'evy processes and stochastic volatility models. We provide a succinct error analysis to demonstrate that we can achieve an exponential convergence rate in the pricing method in many cases as long as we choose the correct definite computational interval. As a novel pricing method, we also numerically demonstrate that complex Fourier series are more accurate and computationally effective when implemented to price in/at/out-of-the-money options or options with complicated contingent claims.
Expression and function of water channels (aquaporins) in migrating malignant astrocytes

Aquaporins (AQP) constitute the principal pathway for water movement across biological membranes. Consequently, their expression and function is important for cell volume regulation. Glioma cells quickly adjust their cell volume in response to osmotic challenges or spontaneously as they invade into the narrow and tortuous extracellular spaces of the brain. These cell volume changes are likely to engage water movements across the cell membrane through AQP. AQP expression in glioma cells is poorly understood. In this study, we examined the expression of AQP in several commonly used human glioma cell lines (D54, D65, STTG1, U87, U251) and in numerous acute patient biopsies by PCR, Western blot, and immunocytochemistry and compared them to nonmalignant astrocytes and normal brain. All glioma patient biopsies expressed AQP1, AQP4 and some expressed AQP5. However, when isolated and grown as cell lines they lose all AQP proteins except a few cell lines that maintain expression of AQP1 (D65, U251, GBM62). Reintroducing either AQP1 or AQP4 stably into glioma cell lines allowed us to show that each AQP is sufficient to restore water permeability. Yet, only the presence of AQP1, but not AQP4, enhanced cell growth and migration, typical properties of gliomas, while AQP4 enhanced cell adhesion suggesting differential biological roles for AQP1 and AQP4 in glioma cell biology. © 2007 Wiley‐Liss, Inc.
Imaging features and surgery-related outcomes in intraventricular neurocysticercosis.

OBJECT Neurocysticercosis (NCC) is the most common parasitic infection of the central nervous system, and its prevalence is continuing to increase in the United States. The diagnosis of intraventricular NCC (IVNCC) may be difficult, and surgery frequently fails to resolve symptoms. A retrospective review of magnetic resonance (MR) imaging characteristics and surgery-related outcomes may improve management strategies of this disease. METHODS The authors report the presentations, neuroimaging characteristics, surgical management, and outcomes of 30 patients with IVNCC treated over a 10-year period (mean follow-up period 4 years). Cysts were located in the lateral ventricles (five cases), the third ventricle (five cases), and the fourth ventricle (21 cases). One patient had lesions in both the lateral and fourth ventricles. Presenting symptoms were related to hydrocephalus or mass effect from the lesions. All patients underwent computerized tomography (CT) and MR imaging of the brain. Treatment consisted of shunt implantation or primary excision of an IVNCC lesion. Outcomes after operations and reoperations were evaluated in light of enhancement characteristics on MR imaging. Computerized tomography scanning demonstrated IVNCC lesions in 10% of cases, and MR revealed lesions in 100% of cases. In patients in whom gadolinium (Gd) enhancement of IVNCC lesions was demonstrated on MR imaging, the surgery-related failure rate was higher and patients required reoperation, and in those in whom gadolinium enhancement was absent the surgery-related failure rate was lower (64 and 19%, respectively; p < 0.0002). CONCLUSIONS Magnetic resonance imaging is superior to CT scanning for detecting IVNCC lesions. The absence of pericystic Gd enhancement on MR imaging is an indication for excision of the lesions. If pericystic enhancement is present, shunt surgery should be performed, and craniotomy reserved for treatment of those patients with symptomatic lesions secondary to mass effect. A treatment algorithm based on patient symptoms, cyst location, and MR imaging Gd enhancement characteristics is proposed.
Microarray analysis revealed markedly differential miRNA expression profiles in cervical intraepithelial neoplasias and invasive squamous cell carcinoma.

AIMS To investigate the alterations in miRNA expression during the progression of dysplasia in cervical epithelium. METHODS A global miRNA expression profile of normal cervical squamous epithelium (Normal), cervical intraepithelial neoplasia (CIN) 3 and invasive squamous cell carcinoma (ISCC) was produced using the seventh generation of the miRCURY™ LNA microRNA Array (Exiqon, Vedbaek, Denmark). The reliability of miRNA arrays was verified by reverse transcription PCR. RESULTS Normal, CIN 3 and ISCC showed distinct miRNA expression profiles. The differentially expressed miRNAs in ISCC versus CIN 3 clearly differed from that in CIN 3 versus Normal. Compared with ISCC versus Normal, more identical miRNAs were found in ISCC versus CIN 3 than in CIN 3 versus Normal. CONCLUSION A particular set of miRNAs was associated with the progression of normal cervical epithelium to CIN 3 and CIN 3 to ISCC. The miRNA profile changed more noticeably in the progression of CIN to ISCC than normal cervical epithelium to CIN.
Determination of the 50% human infectious dose for Norwalk virus.

BACKGROUND Noroviruses are the most common cause of gastroenteritis in the United States. An understanding of the infectious dose of these viruses is important for risk assessment studies. METHODS Healthy adults were enrolled in a randomized, double-blind, placebo-controlled evaluation of different dosages of Norwalk virus. Eligible subjects were monitored for clinical gastroenteritis, and infection status was determined. The presence of virus in vomitus was also assessed. RESULTS Fifty-seven persons were enrolled; 8 received placebo and an additional 8 persons were considered to be nonsusceptible on the basis of being secretor negative. Twenty-one persons were infected (all blood group O or A), and 67% of those infected developed viral gastroenteritis. The 50% human infectious dose was calculated to be 3.3 reverse transcription polymerase chain reaction units (approximately 1320 genomic equivalents [gEq]) for secretor-positive blood group O or A persons and 7.0 (approximately 2800 gEq) for all secretor-positive persons. The time of illness onset was inversely correlated with inoculum dose. The maximal concentration of virus shedding was higher for persons with gastroenteritis. Norwalk virus was identified in 15 of 27 (56%) vomitus samples at a median concentration of 41 000 gEq/mL. CONCLUSIONS The 50% human infectious dose measured is higher than previous estimates and similar to that of other RNA viruses. Clinical Trials Registration NCT00138476.
Reversal of temperature‐induced conformational changes in the amyloid‐beta peptide, Aβ40, by the β‐sheet breaker peptides 16–23 and 17–24

Background and purpose: Aggregates of the protein amyloid‐beta (Aβ) play a crucial role in the pathogenesis of Alzheimer's disease (AD). Most therapeutic approaches to AD do not target Aβ, so determination of the factor(s) that facilitate aggregation and discovering agents that prevent aggregation have great potential therapeutic value.
SAFE GAME OF COMPETITIVE DIFFUSION

Competitive Diffusion is a recently introduced game-theoretic model for the spread of information through social networks. The model is a game on a graph with external players trying to reach the most vertices. In this thesis, we consider the safe game of Competitive Diffusion. This is the game where one player tries to optimize his gain as before, while his opponents’ objectives are to minimize the first player’s gain. This leads to a safety value for the player, i.e. an optimal minimal expected gain no matter the strategies of the opponents. We discuss safe strategies and present some bounds on the safety value in the two-player version of the game on various graphs. The results are almost entirely on the safe game on trees, including the special cases of paths, spiders and complete trees but also consist of some preliminary studies of the safe game on three other simple graphs. Our main result consists of a Centroidal Safe Strategy (CSS) Algorithm which suggests a safe strategy for a player on any centroidal tree, a tree which has one vertex as centroid, and gives its associated guaranteed gain.
Open-Domain, Content-based, Multi-modal Fact-checking of Out-of-Context Images via Online Resources

Misinformation is now a major problem due to its poten-tial high risks to our core democratic and societal values and orders. Out-of-context misinformation is one of the easiest and effective ways used by adversaries to spread vi-ral false stories. In this threat, a real image is re-purposed to support other narratives by misrepresenting its context and/or elements. The internet is being used as the go-to way to verify information using different sources and modali-ties. Our goal is an inspectable method that automates this time-consuming and reasoning-intensive process by fact-checking the image-caption pairing using Web evidence. To integrate evidence and cues from both modalities, we intro-duce the concept of ‘multi-modal cycle-consistency check’ starting from the image/caption, we gather tex-tual/visual evidence, which will be compared against the other paired caption/image, respectively. Moreover, we propose a novel architecture, Consistency-Checking Network (CCN), that mimics the layered human reasoning across the same and different modalities: the caption vs. textual evidence, the image vs. visual evidence, and the image vs. caption. Our work offers the first step and bench-mark for open-domain, content-based, multi-modal fact-checking, and significantly outperforms previous baselines that did not leverage external evidence11For code, checkpoints, and dataset, check: https://s-abdelnabi.github. io/OoC-multi-modal-fc/.
Brain Integrity and Cerebral Atrophy in Vietnam Combat Veterans with and without Posttraumatic Stress Disorder

Posttraumatic stress disorder (PTSD) is associated with decreased hippocampal volume, but the relationship between trauma and brain morphology in the absence of PTSD is less clear. In this study, measures of brain integrity were determined by estimating gray and white matter regional brain volumes using structural magnetic resonance imaging in six patients with PTSD and in five controls with comparable trauma exposure but without clinical evidence of PTSD. The only statistically significant volume difference between groups was observed multivariately in the white matter of the right temporal lobe (superior temporal gyrus, fusiform gyrus, parahippocampal gyrus, white-matter stem, middle temporal gyrus, and inferior temporal gyrus), although small sample sizes limit the power to detect between-group differences. Both groups showed heterogeneity in cerebral atrophy.
Acute von Willebrand Factor Secretion from the Endothelium In Vivo: Assessment through Plasma Propeptide (vWf:AgII) Levels

Summary Elevated plasma concentrations of von Willebrand factor (vWf) are increasingly recognized as a cardiovascular risk factor, and are used as a marker of endothelial activation. However, the factors which determine the rate of vWf release from the endothelium in vivo have not been defined clearly. In addition, vWf plasma levels may also be influenced by adhesion of vWf to the vascular wall or to platelets, and by its rate of degradation. The propeptide of vWf (also called vWf:AgII) is stored and released in equimolar amounts with vWf. In the present study we attempted to determine whether this propeptide could be a more reliable marker of endothelial secretion than vWf itself. To accomplish this we developed an ELISA based on monoclonal antibodies. The propeptide levels in normal plasma were found to be 0.7 µg/ml, more than 10 times lower than vWf itself. Administration of desmopressin (DDAVP) induced a rapid relative increase in propeptide (from 106 to 879%) and in vWf (from 112 to 272%). However, the increases in vWf and propeptide were equivalent when expressed in molar units. A time course study indicated a half-life of the propeptide of 3 h or less. In a baboon model of disseminated intravascular coagulation (DIC) induced by FXa, vWf increased by less than 100%, whereas the propeptide concentrations increased by up to 450%. In view of the massive thrombin generation (as assessed by fibrinogen depletion), the increases in vWf are small, compared to the strong secretory response to thrombin and fibrin previously observed in vitro. Our results suggest that due to its rapid turnover, the propeptide could provide a sensitive plasma marker of acute endothelial secretion.
A robot simulator for manufacturing tasks on a component-based software development and execution framework

The authors propose a new robot simulator for manufacturing tasks with easy-to-customize capability. In order to simplify the customization of the simulator according to the required tasks or the characteristics of each robot, the main algorithms for motion calculation are developed as a component with specific functions on the component-based software development and execution framework named the "MZ Platform". As the simulation system is constructed by combining the different components, a function of the simulation can be easily changed by replacing the components. Its cooperative use with other applications on the MZ Platform is also possible
The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity

Summary: The innate immune system consists of a cellular arm and a humoral arm. Components of humoral immunity include diverse molecular families, which represent functional ancestors of antibodies. They play a key role as effectors and modulators of innate resistance in animals and humans, interacting with cellular innate immunity. The prototypic long pentraxin, pentraxin 3 (PTX3), represents a case in point of this interplay. Gene targeting of this evolutionarily conserved long pentraxin has unequivocally defined its role at the crossroads of innate immunity, inflammation, matrix deposition, and female fertility. Phagocytes represent a key source of this fluid‐phase pattern recognition receptor, which, in turn, facilitates microbial recognition by phagocytes acting as an opsonin. Moreover, PTX3 has modulatory functions on innate immunity and inflammation. Here, we review the studies on PTX3 which emphasize the complexity and complementarity of the crosstalk between the cellular and humoral arms of innate immunity.
Simple Model for Considering Word of Mouth on Cultural Creative Goods

Cultural creative goods usually have public goods characteristics and use non-market valuation techniques. Cultural value may contain elements that cannot be expressed by any quantitative or qualitative scale. When a consumer decides to purchase cultural creative goods, interpersonal influence and word of mouth (WOM) are the most of important information sources. The main purpose of this study was to present a simple model for considering word of mouth (WOM) and characteristics of the products on the maximize profits for cultural creative goods. Mathematical model developed for cultural creative goods were constructed. For the managers wanted to recommend their cultural creative goods to market, we give some suggestion about how to price. The model showed that in marketing cultural creative goods, when the market expands, its optimal price rises; and when the market matures, its optimal price falls.