Miracle-dz/UniFAR-FTUs huggingface dataset:
Summary of notifiable diseases--United States, 2003.

The Summary of Notifiable Diseases--United States, 2003 contains the official statistics, in tabular and graphic form, for the reported occurrence of nationally notifiable diseases in the United States for 2003. Unless otherwise noted, the data are final totals for 2003 reported as of June 30, 2004. These statistics are collected and compiled from reports sent by state health departments to the National Notifiable Diseases Surveillance System (NNDSS), which is operated by CDC in collaboration with the Council of State and Territorial Epidemiologists (CSTE). The Summary is available at http://www.cdc. gov/mmwr/summary.html. This site also includes publications from past years.
Effectiveness of a Computerized Insulin Order Template in General Medical Inpatients With Type 2 Diabetes

OBJECTIVE To determine whether an electronic order template for basal-bolus insulin ordering improves mean blood glucose in hospitalized general medical patients with hyperglycemia and type 2 diabetes. RESEARCH DESIGN AND METHODS We randomly assigned internal medicine resident teams on acute general medical floors to the use of an electronic insulin order template or usual insulin ordering. We measured diabetes care parameters for 1 month on all patients with type 2 diabetes and blood glucose <60 mg/dl or >180 mg/dl treated by these physicians. RESULTS Intervention group patients (n = 65) had mean glucose of 195 ± 66 mg/dl. Control group patients (n = 63) had mean glucose of 224 ± 57 mg/dl (P = 0.004). In the intervention group, there was no increase in hypoglycemia. CONCLUSIONS Access to a computer insulin order template was associated with improved mean glucose levels without increasing hypoglycemia in patients with type 2 diabetes.
Sequence encoding in preverbal infants : an electrophysiological perspective

A ce jour, seul le cerveau du nourrisson est capable d’apprehender et de maitriser la complexite du langage humain. La recherche en psychologie du developpement a investi beaucoup d’energie pour tenter de percer le mystere de l’acquisition du langage, revelant d’impressionnantes capacites precoces permettant le traitement et la representation de la parole. La recente emergence de techniques de neuro-imagerie non-invasives offre aujourd’hui de nouveaux outils et de nouvelles perspectives pour d’etude des mecanismes d’apprentissage du langage. Cette these a pour but d’explorer les mecanismes permettant l’acquisition et la representation de structures linguistiques, grâce a une approche en electrophysiologie. La premiere partie de ce manuscrit consiste en une contribution methodologique a la neuro-imagerie du developpement. Sur la base de donnees acquises en imagerie par resonnance magnetique (IRM), nous avons localise les positions du systeme international 10/20 pour le placement d’electrodes – utilise aussi bien en electroencephalographie (EEG) qu’en spectroscopie proche infra-rouge (NIRS) – par rapport aux structures cerebrales internes. Cette etude a permis de quantifier la variabilite interindividuelle de ces positions, mais egalement de construire un modele de cerveau complete d’un atlas anatomique pour le nourrisson. Dans une seconde partie de cette these, grâce a l’EEG haute-densite, nous avons pu demontrer que des 8 mois, les nourrissons etaient capables de mettre en œuvre de puissance mecanismes d’analyse statistique, permettant d’extraire les dependances entre syllabes non-adjacentes, pour segmenter un flux continu de parole en unites distinctes. L’analyse des reponses neurales a revele une hierarchie de processus cerebraux soutenant le traitement des syllabes mais aussi des unites segmentees. Enfin, dans une derniere partie, nous proposons un paradigme experimental permettant d’etudier non seulement l’extraction mais aussi la representation de sequences linguistiques sous la forme d’expressions unifiees. Nous avons pu etablir grâce a cette etude que des 5 mois, les nourrissons etaient capables de former de solides representations de sequences definies par des repetitions, leur permettant de categoriser et manipuler plusieurs structures. Pour conclure, cette these vient completer les etudes comportementales sur l’acquisition du langage, grâce a une approche des processus cerebraux soutenant l’apprentissage de sequences. La richesse du signal EEG a permis de mettre en evidence une hierarchie de traitements complexes.
Ion transport by neonatal rabbit distal colon.

The neonatal small intestine is characterized by electrical conductance and permeability to ions higher than in the corresponding adult intestine. To investigate whether this property of the neonate is limited to the small intestine, or extends to the colon, a modified Ussing chamber for determination of transmucosal potential difference (PD), short-circuit current (Isc), transepithelial conductance (Gt), and ion fluxes in the neonatal rabbit distal colon was constructed. After care to reduce edge damage, Gt for the neonatal colon was found to be 8.4 +/- 0.3 mS . cm2 and for adult colon in the same chamber, 7.4 +/- 0.5 (P greater than 0.05). Net Na and Cl fluxes under short-circuit conditions were similar to those obtained in adult colon. Unidirectional ion fluxes were also similar to those of the adult. Net Na flux (JNanet) was incompletely inhibited by 10(-4) M of amiloride. Response to replacement of Na, Cl, and HCO3-, respectively, in the bathing solutions was not different from that expected in adult rabbit colon. Thus differences between adult and neonatal rabbit colon were small, and the increased conductance and unidirectional ion fluxes characteristic of the neonatal small intestine were not evident in the neonatal rabbit distal colon.
Experimental Observation of Topologically Protected Helical Edge Modes in Patterned Elastic Plates

The investigation of topologically protected waves in classical media has opened unique opportunities to achieve exotic properties like one-way phonon transport, protection from backscattering and immunity to imperfections. Contrary to acoustic and electromagnetic domains, their observation in elastic solids has so far been elusive due to the presence of both shear and longitudinal modes and their modal conversion at interfaces and free surfaces. Here we report the experimental observation of topologically protected helical edge waves in elastic media. The considered structure consists of an elastic plate patterned according to a Kagome architecture with an accidental degeneracy of two Dirac cones induced by drilling through holes. The careful breaking of symmetries couples the corresponding elastic modes which effectively emulates spin orbital coupling in the quantum spin Hall effect. The results shed light on the topological properties of the proposed plate waveguide and opens avenues for the practical realization of compact, passive and cost-effective elastic topological waveguides.
INVESTIGATING THE ROLE OF DISPOSITIONAL MINDFULNESS AS A PROTECTIVE FACTOR FOR BODY IMAGE DISSATISFACTION AMONG WOMEN

Body image dissatisfaction, which is increasing as an issue for women, can diminish quality of life with negative psychological consequences. The relat ionship between internalizing the thin body ideal and the development of body image dissatisfaction h as been studied in psychology. The thin body ideal is aspiring to a perfect female body that is very t hin, presented as the ideal in the media. Research has focused on investigating strategies that women use to resist internalizing a thin-ideal body and preve nt developing body dissatisfaction. The present study investigated the protective benefits of disposition al mindfulness against developing body image dissatisf action in a sample of 186 women aged between 18 to 64 years (M = 29). The results suggest that comp ared to women with low levels of dispositional mindfulness, women with high levels of dispositiona l mindfulness report significantly less body image dissatisfaction and preoccupation with weight, lowe r levels of shame, psychological distress and higher levels of self-esteem.
Polymers for Use in Controlled Release Systems: The Effect of Surfactants on their Swelling Properties

The effect of an ampholytic surfactant on the swelling properties of polymeric materials was studied, using various swelling liquids. Tablets were prepared consisting of hydroxypropyl methylcellulose, poly(oxyethylene) and sodium alginate. Tego betain was the non-ionic surfactant used as an additive in a series of samples made of the above polymers. Those tablets were immersed in distilled water, phosphate buffer and 0.1 N HCl, and their weight uptake was recorded as a function of time, in order to assess the swelling process. Measurements of the contact angle of the above systems were also carried out for estimating their wetting properties. The results of this study showed a selectivity among polymers, surfactant and surrounding liquid. Clearly, an enhancement of the swelling capacity of hydroxypropyl methylcellulose tablets due to the surfactant was recorded. An unclear effect was observed in the case of poly(oxyethylene), whereas for sodium alginate, the dominant factor is its water solubility that controls swelling behaviour.
Diseño e implementación de un equipo de robots autónomos que toman decisiones en tiempo real: futbol robótico-componente inteligente

El presente trabajo trata el desarrollo del componente inteligente, que tiene como objetivo principal controlar las posiciones de los robots, implementar los algoritmos que generan estrategias de juego para los robots, haciendo uso de la informacion del entorno del trabo de los robots, mismo que es dado por el componente de vision tal como las posiciones de cada objeto, su orientacion, etc. Ademas realiza la importancia de estudiar el futbol robotico como plataforma de desarrollo para sistemas multiagente.
Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure.

There are obviously several causes of myocardial dysfunction but energy deficiency of the myocytes may play a significant role and probably is a common mechanism during the progression of myocardial failure. Theoretically, a poor utilization efficiency of oxygen may be due to exhaustion of the myocardial stores of bioenergetics. In this report the authors review their biochemical results from measurements of coenzyme Q10 (CoQ10) levels in blood and human endomyocardial biopsies using an HPLC method from patients with suspected myocardial disease (n = 45). The levels of CoQ10, which has a key role in the respiratory chain and the synthesis of ATP, was found to be significantly decreased in various groups of patients with myocardial failure (dilated and restrictive cardiomyopathy and alcoholic heart disease) as compared to "normal" myocardium (0.42 +/- 0.04 micrograms/mg dry weight). The deficiency of CoQ10 was more pronounced with increasing symptoms; e.g. patients with dilated cardiomyopathy in NYHA Classes III and IV had lower tissue CoQ10 content than those of Classes I and II (0.28 +/- 0.04 vs. 0.37 +/- 0.06 micrograms/mg, p less than 0.001). Nearly two thirds of a series of 40 patients in severe heart failure (Classes III and IV) treated with CoQ10, 100 mg daily, in an open, controlled design showed subjective and objective improvement. Clinical responders were 69% and 43% of patients with cardiomyopathy and ischaemic heart disease, respectively. The results suggest that CoQ10 is a novel and effective breakthrough in heart-failure therapy and it appears safe, as no adverse reactions were registered. The through in heart-failure therapy and it appears safe, as no adverse reactions were registered. (ABSTRACT TRUNCATED AT 250 WORDS)
Clinical Informatics Fellowship Programs: In Search of a Viable Financial Model

Summary In the US, the new subspecialty of Clinical Informatics focuses on systems-level improvements in care delivery through the use of health information technology (HIT), data analytics, clinical decision support, data visualization and related tools. Clinical informatics is one of the first subspecial-ties in medicine open to physicians trained in any primary specialty. Clinical Informatics benefits patients and payers such as Medicare and Medicaid through its potential to reduce errors, increase safety, reduce costs, and improve care coordination and efficiency. Even though Clinical Informatics benefits patients and payers, because GME funding from the Centers for Medicare and Medicaid Services (CMS) has not grown at the same rate as training programs, the majority of the cost of training new Clinical Informaticians is currently paid by academic health science centers, which is unsustainable. To maintain the value of HIT investments by the government and health care organizations, we must train sufficient leaders in Clinical Informatics. In the best interest of patients, payers, and the US society, it is therefore critical to find viable financial models for Clinical Informatics fellowship programs. To support the development of adequate training programs in Clinical Informatics, we request that the Centers for Medicare and Medicaid Services (CMS) issue clarifying guidance that would allow accredited ACGME institutions to bill for clinical services delivered by fellows at the fellowship program site within their primary specialty. Citation: McCoy AB, Wright A, Krousel-Wood M, Thomas EJ, McCoy JA, Sittig DF. Validation of a crowdsourcing methodology for developing a knowledge base of related problem-medication pairs. Appl Clin Inf 2015; 6: 334–344 http://dx.doi. org/10.4338/ACI-2015-01-RA-0010
Characterization of Phytophthora nicotianae isolates in southeast Spain and their detection and quantification through a real-time TaqMan PCR.

BACKGROUND The soil-borne pathogens Phytophthora nicotianae and P. capsici are the causal agents of root and stem rot of many plant species. Although P. capsici was considered the causal agent in one of the main pepper production areas of Spain to date, evidence of the presence of P. nicotianae was found. We aimed to survey the presence of P. nicotianae and study the variability in its populations in this area in order to improve the management of Tristeza disease. RESULTS A new specific primer and a TaqMan probe were designed based on the internal transcribed spacer regions of ribosomal DNA to detect and quantify P. nicotianae. Both morphological and molecular analysis showed its presence and confirmed it to be the causal agent of the Phytophthora disease symptoms in the studied area. The genetic characterization among P. nicotianae populations showed a low variability of genetic diversity among the isolates. Only isolates of the A2 mating type were detected. CONCLUSIONS Not only is a specific and early detection of P. nicotianae essential but also the study of genetic variability among isolates for the appropriate management of the disease, above all, in producing areas with favorable conditions for the advance of the disease. © 2014 Society of Chemical Industry
Regional Anesthesia Group Practice in Multihospital Private Practice Settings and in Orthopedic Specialty Hospitals

Through the process of establishing a regional anesthesia (RA) program in a multihospital private practice setting, there are 12 necessary steps, each of which is reviewed in some detail: 1) survey the practicing anesthesiologists in your group; 2) ask yourself why you are interested in establishing a RA program for your practice; 3) ask yourself ‘‘why not? ’’ Why wouldn’t you want to start a RA program in your facility? 4) Ask yourself ‘‘whom? ’’ Who within your group would work with you in establishing a new RA program? 5) Ask yourself ‘‘where? ’’ Where in particular would the RA program bemost useful and successful? 6)Make a decision as to whether you proceed with setting up the program or not; 7) create the RA and acute pain service; 8) establish needed education for everyone involved with patient care that may be affected by starting the RA/acute pain program; 9) keep it simple, to the extent possible; 10) use as much teamwork as possible; 11) continue to communicate with all parties involved, including surgeons, nursing staff, patients, families, and so on; and 12) maintain the program with continuing education efforts, as well as through regular meetings and discussions within your group.
Etiology as a risk factor for medically refractory epilepsy

Epilepsy is a common, treatable neurologic disorder; however, 20 to 30% of patients with epilepsy have seizures that cannot be completely controlled by antiepileptic drugs.1 As many as half of these patients are potential candidates for surgical treatment.2 A recent advance in surgical treatment for epilepsy is the recognition that among these medically refractory patients are identifiable subgroups who have surgically remediable syndromes.3 These syndromes have a well-defined pathophysiology and natural history, can be identified by noninvasive diagnostic evaluation, and are resistant to pharmacotherapy, but have a high surgical cure rate. Because seizures and their behavioral consequences are progressive, early surgical intervention may prevent irreversible disability. The prototypic surgically remediable syndrome is mesial temporal lobe epilepsy (MTLE), the form of TLE associated with hippocampal sclerosis.4 With modern techniques, 80 to 90% of patients with MTLE become seizure free after anteromesial temporal lobectomy.3,4 Traditional arguments that antiepileptic drugs are usually ineffective, that the condition becomes worse over time, and that surgical treatment is underused because MTLE is a common disorder and surgery is performed relatively rarely are based predominantly on anecdotal evidence derived from patients referred for epilepsy surgery. In this issue, Semah et al.5 provide important new data on the prevalence and prognosis of specific epileptic disorders, including MTLE, encountered over a …
The role of the blood bank in hematopoietic stem cell transplantation

BONE MARROW TRANSPLANTATION (BMT) is currently being used to treat a broad spectrum of malignant and nonmalignant diseases. Refinements in testing for HLA compatibility, coupled with new approaches to prevent as well as treat graft-versus-host disease (GVHD), have resulted in widespread use of allogeneic BMT. '" Only 30 to 40 percent of patients have HLA-matched related donors; however, allogeneic BMT using related donors other than HLA-identical siblings or unrelated HLA-matched donors has demonstrated promising preliminary result^. ^-^ Moreover, autologous BMT, with or without purging of marrow tumor cells, is increasingly being used to treat both hematologic cancers and solid turn or^. ^ The role of the blood component laboratory in BMT is central and multifaceted. 'OJ1 This review will focus specifically on the following aspects: donor typing and recruitment; ABO compatibility in allogeneic BMT; the avoidance of transfusion-related alloimmunization, GVHD, and infection in patients undergoing BMT; bone marrow processing and cryopreservation; documentation of engraftment; immune cytopenia after BMT; and future directions, including the use of peripheral blood stem cells (PBSCs) and recombinant growth factors to hasten engraftment and lessen the toxicity of high-dose ablative treatments. Transfusion medicine expertise is central and essential to all of these aspects of hematopoietic stem cell transplantation, both in current practice and in furthering research efforts.
Etude de la dynamique de dégranulation des mastocytes et analyse de l'effet des éicosanoïdes dans la coopération entre mastocytes et lymphocytes T Helper

Les mastocytes sont des cellules immunitaires presentes dans tous les tissus de l'organisme. Ils ont ete depuis longtemps associes aux reponses allergiques, mais ces cellules sont aussi des acteurs majeurs de la reponse inflammatoire. La degranulation des mastocytes, ou exocytose des granules secretoires, est un mecanisme d'action important de ces cellules. Au laboratoire, nous avons mis au point une methode innovante qui nous permet de suivre en temps reel la dynamique de cette degranulation. Cette methode repose sur l'utilisation de l'avidine couple a un fluorochrome qui se lie specifiquement a la matrice des granules. Nous avons recherche les modalites de la degranulation lorsque les mastocytes sont actives par un ligand cellulaire comme des cellules cibles recouvertes d'anticorps. Nous avons pu mettre en evidence, de facon surprenante, que les mastocytes degranulent de maniere polarisee contre une cellule cible opsonisee avec des anticorps de type IgE ou IgG en mettant en place un nouveau mecanisme que nous avons nomme ADDS (Antibody Dependent Degranulatory Synapse). L'ADDS est caracterisee par une signalisation du recepteur RFc et une depolymerisation du cytosquelette cortical d'actine locales. De plus, cette synapse peut aussi avoir lieu lorsque le mastocyte est au contact d'un parasite opsonise comme Toxoplasma Gondii, et induit la mort du parasite et la liberation de cytokines et chimiokines pro-inflammatoires. Nous avons ensuite analyse la dynamique de la degranulation a l'echelle " single cell " et sa regulation par des facteurs inflammatoires. Grâce a une approche de " cell barcoding " et de cytometrie en flux en temps reel, nous avons pu mettre en evidence que la degranulation induite par l'agregation des RFc? I etait controlee par deux mecanismes : un premier qui regle le nombre de mastocytes qui degranulent et un second qui regule l'intensite de la degranulation. L'interleukine 33 peut finement potentialiser ces deux mecanismes en augmentant le pourcentage de mastocytes qui degranulent et l'intensite de la degranulation. L'IL-33 induit ainsi l'emergence de cellules hautement inflammatoires. Dans un second axe de recherche, nous avons etudie quel pouvait etre l'impact des prostaglandines dans le dialogue entre mastocytes et lymphocytes T CD4+ Helper (TH). Nos resultats indiquent un role insoupconne de la prostaglandine D2 et la prostaglandine E2 comme des acteurs importants pour la production d'interleukine 17 par les LTH. En conclusion, mon travail de these nous a permis de reveler l'existence de la synapse degranulatoire des mastocytes, de nouveaux mecanismes controlant la degranulation et d'identifier les mastocytes comme une source importante de prostaglandines impliquees dans la polarisation des LTH.
University of Birmingham A Reliable Marker of Vascular Function: Does It Exist?

Publisher Rights Statement: NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Cardiovascular Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in Cardiovascular Medicine, DOI: 10.1016/j.tcm. 2015.03. 005