Miracle-dz/UniFAR-FTUs huggingface dataset:
Respiratory medicine in Saskatchewan: An historical perspective.

Department of Medicine Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan Correspondence: Dr DW Cockcroft, Division of Respirology, Critical Care and Sleep Medicine, Royal University Hospital, 103 Hospital Drive, Ellis Hall, Room 551, Saskatoon, Saskatchewan S7N 0W8. Telephone 306-844-1140, fax 306-844-1532, e-mail don.cockcroft@usask.ca DW Cockcroft. Respiratory medicine in Saskatchewan: An historical perspective. Can Respir J 2015;22(4):ee27-e31.
E-business Adoption among SMEs in China: A Study of the Perceptions of SMEs in Hunan Province

The significance of small and medium-sized enterprises (SMEs) for China’s economy has received increasing attention over the last decade, with the latest official reports suggesting that it is becoming increasingly difficult to ignore the key role of e-business in sustaining and developing China’s SMEs and an unprecedented range of benefits brought by the business innovation. This thesis reviews the most commonly used research theories and conceptual models in the research area of organisational technology adoption, taking into account the characteristics of business environment faced by SMEs in China. It appears that Diffusion of Innovation theory (DOI) has the greatest potential to provide a useful framework for explaining the unique phenomenon. Based on the proposed conceptual model derived from DOI, this study investigates the role of e-business in developing and sustaining SMEs in China and how small business decision makers perceive the innovation, through examining the applicability of the adoption elements and adapting them to fit the business context. This research is one of the first to comprehensively study e-business and SMEs by adopting China’s latest SME criteria which was released by the Ministry of Industry and Information Technology of China in 2011. The findings reveal that DOI theory is applicable to e-business adoption issues for SMEs in China, with all of the four proposed elements being found relevant. The study has valuable implications to practitioners and policy makers in general, and can serve as the theoretical basis for future research.
The speckled golfer

This paper describes the application of the first fully wireless network of inertial sensors for full-body 3-D motion capture -- the Orient-2 system, to real-time on-body analysis of the golf swing. The golfer-club system is modelled as a double pendulum. The factors which affect the efficiency of the golf swing are outlined, such as the length of the back swing, the wrist-cock angle, swing plane and club-head speed and methods are described for monitoring them using a wireless network of Orient-2 specks. The implementation of the Speckled Golfer System is described and two motion rules are illustrated for executing efficient golf swings.
Medication and non-adherence in the older adult.

Ms. D, a 65-year-old woman with hypertension and diabetes, presented to your office for a routine appointment. Her most recent hemoglobin A1C was 9.0. On examination, her vital signs were normal with the exception of blood pressure which was 165/85. Her medications included zestoretic and pioglitazone. On questioning, she revealed that she has not been able to buy her medications because they are too expensive: she had reached the ‘donut hole’ in her prescription coverage plan.
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes

Histone deacetylases (HDACs) are thought to function as critical mediators of transcriptional repression. However, the physiological targets and posttranslational modifications of the class II HDACs are largely unknown. Here we show that the C terminus of HDAC 6 is both necessary and sufficient for specific association with polyubiquitin. This region contains a putative zinc finger but lacks significant similarity to other known ubiquitin binding domains. Thus, we have designated this region as a PAZ domain, for Polyubiquitin Associated Zinc finger. Although the PAZ domain possesses homology with the zinc finger of deubiquitinating enzymes, it is dispensable for the deubiquitinating activity we find associated with HDAC6 following immunopurification. We also show that both HDAC 5 and HDAC 6 are ubiquitinated in vitro and in vivo. However, both of these proteins are stable in vivo and do not appear to be targeted for rapid degradation by the proteasome. Thus, HDAC6 is linked to the ubiquitin system via ubiquitin conjugation, polyubiquitin binding, and copurification with deubiquitinating enzymes.
Acoustic energy radiated by nonlinear spherical oscillations of strongly driven bubbles

Based on the theory of F. Gilmore (Gilmore 1952The growth or collapse of a spherical bubble in a viscous compressible liquid) for radial oscillations of a bubble in a compressible medium, the sound emission of bubbles in water driven by high-amplitude ultrasound is calculated. The model is augmented to include expressions for a variable polytropic exponent, hardcore and water vapour. Radiated acoustic energies are calculated within a quasi-acoustic approximation and also a shock wave model. Isoenergy lines are shown for driving frequencies of 23.5 kHz and 1 MHz. Together with calculations of stability against surface wave oscillations leading to fragmentation, the physically relevant parameter space for the bubble radii is found. Its upper limit is around 6 μm for the lower frequency driving and 1–3 μm for the higher. The radiated acoustic energy of a single bubble driven in the kilohertz range is calculated to be of the order of 100 nJ per driving period; a bubble driven in the megahertz range reaches two orders of magnitude less. The results for the first have applications in sonoluminescence research. Megahertz frequencies are widely used in wafer cleaning, where radiated sound may be implicated as responsible for the damage of nanometre-sized structures.
Patterns of lung cancer risk according to type of cigarette smoked

A case‐control study of lung cancer involving interviews with 7,804 cases and 15,207 hospital‐based controls was carried out in seven locations in Western Europe. The large study size permitted the calculation of precise estimates of the relative risk of lung cancer associated with smoking different types of cigarettes. Lifelong nonfilter smokers were at nearly twice the risk of lung cancer compared to lifelong filter smokers after controlling for duration of cigarette use and number smoked per day (RR = 1.7 for males and 2.0 for females). Lung cancer risks for filter, nonfilter and mixed smokers increased in proportion to intensity and duration of smoking and decreased with years since stopping smoking. The findings indicate that prevention activities should continue to emphasize smoking cessation, although switching to low‐tar cigarettes may also yield some reductions in lung cancer risk.
Synaptic input to OFF parasol ganglion cells in macaque retina

A Neurobiotin‐injected OFF parasol cell from midperipheral macaque retina was studied by reconstruction of serial ultrathin sections and compared with ON parasol cells studied previously. In most respects, the synaptic inputs to the two subtypes were similar. Only a few of the amacrine cell processes that provided input to the labeled OFF parasol ganglion cell dendrites made or received inputs within the series, and none of these interactions were with the bipolar cells or other amacrine cells presynaptic to the OFF parasol cell. These findings suggest that the direct inhibitory input to OFF parasol cells originates from other areas of the retina. OFF parasol cells were known to receive inputs from two types of diffuse bipolar cells. To identify candidates for the presynaptic amacrine cells, OFF parasol cells were labeled with Lucifer yellow by using a juxtacellular labeling technique, and amacrine cells known to costratify with them were labeled via immunofluorescent methods. Appositions were observed with amacrine cells containing immunoreactive calretinin, parvalbumin, choline acetylatransferase, and G6‐Gly, a cholecystokinin precursor. These findings suggest that the inhibitory input to parasol cells conveys information about several different attributes of visual stimuli and, particularly, about their global properties. J. Comp. Neurol. 498:46–57, 2006. © 2006 Wiley‐Liss, Inc.
The Differential Diagnosis of Adult Onset Metachromatic Leukodystrophy and Early Onset Familial Alzheimer Disease in an Alzheimer Clinic Population

ABSTRACT: Clinical differentiation between forms of progressive dementia can prove difficult, particularly when relatively rare forms of dementia are involved. Factors such as family history of dementia, age at onset, presenting features such as personality change, cognitive deficits, psychiatric symptoms, and clinical course (progressive deterioration; retention of skills over time) may prove useful for directing investigations to identify underlying pathology and genetic implications. This is illustrated by two patient reports. Each patient had the onset of memory/behavioral problems at approximately age 40 years, was initially given a psychiatric, non-dementing diagnosis, and had a positive family history for early onset behavioral and memory problems. After longitudinal assessment, the diagnosis of Alzheimer disease was confirmed at autopsy in one patient and a diagnosis of familial, adult-onset metachromatic leukodystrophy in the other.
A Critical Review Of The Basel Margin Of Conservatism Requirement In A Retail Credit Context

The Basel II accord (2006) includes guidelines to financial institutions for the estimation of regulatory capital (RC) for retail credit risk. Under the advanced Internal Ratings Based (IRB) approach, the formula suggested for calculating RC is based on the Asymptotic Risk Factor (ASRF) model, which assumes that a borrower will default if the value of its assets were to fall below the value of its debts. The primary inputs needed in this formula are estimates of probability of default (PD), loss given default (LGD) and exposure at default (EAD). Banks for whom usage of the advanced IRB approach have been approved usually obtain these estimates from complex models developed in-house. Basel II recognises that estimates of PDs, LGDs, and EADs are likely to involve unpredictable errors, and then states that, in order to avoid over-optimism, a bank must add to its estimates a margin of conservatism (MoC) that is related to the likely range of errors. Basel II also requires several other measures of conservatism that have to be incorporated. These conservatism requirements lead to confusion among banks and regulators as to what exactly is required as far as a margin of conservatism is concerned. In this paper, we discuss the ASRF model and its shortcomings, as well as Basel II conservatism requirements. We study the MoC concept and review possible approaches for its implementation. Our overall objective is to highlight certain issues regarding shortcomings inherent to a pervasively used model to bank practitioners and regulators and to potentially offer a less confusing interpretation of the MoC concept.
Physical principles in the construction of regular viruses.

Florida Press, Gainesville, Florida, pp. 267-291. Caspar, D. L. D. (1965) "Design Principles in Virus Particle Construction. " In Viral and Rickettsial Infections of Man, 4th edition (Horsfall, F. L., Jr. and Tamm, I., eds.), J. B. Lippincott Co., Philadelphia, pp. 51-93. Caspar, D. L. D. (1966) "An Analogue for Negative Staining. " "Physical principles in the construction of regular viruses. " Cold Spring Harb Symp Quant Biol 27 (1962): 1-24. b) Liddington, R. C. , Y. Yan, J. Moulai, R. Sahli, T. L. Benjamin, and S. C. Harrison. c) Flint S.J., Enquist L.W. , Racaniello V. R. , Skalka A. M. “Principles of virology”, Chapter “Packaging the nucleic acid genome”, pp 109-112. d) Flint S.J., Enquist L.W. , Racaniello V. R. , Skalka A. M. “Principles of virology”, Chapter “Viruses with envelopes”, pp 114-121. 4. Nucleic Acid Packaging and Ejection. a) D'Souza, V. , and M. F. Summers. "Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus. " How do the architectures of our designs compare to those of virus capsids and other icosahedral protein complexes found in nature? Our designs obey strict icosahedral symmetry, with the asymmetric unit in each case containing a heterodimer that comprises one subunit from each of the two components. The most similar naturally occurring structures of which we are aware are cowpea mosaic virus (CPMV) and related 120-subunit capsids with pseudo T = 3 symmetry [T refers to the triangulation number 27)]. , Physical principles in the construction of regular viruses. Cold Spring Harb. Symp. Home About Archive Purchase Advertise Alerts Contact Privacy Policy Help
Identification of lysis protein E of bacteriophage phiX174

The product of gene E, the lysis gene of phiX174, has been identified as a distinct band in a sodium dodecyl sulfate-gel electropherogram. The position of the band is consistent with the molecular weight of 10,589 calculated from the nucleotide sequence of the gene. The band is eliminated by a nonsense mutation in gene E. It is estimated that roughly 100 to 300 molecules of E protein are made in an infected cell; this appears to be less than one-tenth the amount of protein made by gene D, in which gene E is wholly contained.
What happened to the East German housing market? A historical perspective on the role of public funding

This article analyses the development of the East German housing market after reunification of the former German Democratic Republic and the Federal Republic of Germany in 1990. We analyse the dynamics of the East German housing market within the framework of the well known stock-flow model, proposed by DiPasquale and Wheaton. We show that the disequilibrium observable today is to a large extent caused by post-reunification housing policy and its strong fiscal incentives to invest in the housing stock. Moreover, in line with the stylised empirical facts we show that ‘hidden reserves’ of the housing market were reactivated since the economy of East Germany became market-organised. Since initial undersupply was overcome faster than politicians expected, the fiscal stimuli implemented were too strong. In contrast to the widespread opinion that outward migration caused the observable vacancies, this study shows that not weakness of demand but supply side policies caused the observable disequilibrium.
Prevalence of antibodies to beta2-glycoprotein I in systemic lupus erythematosus and their association with antiphospholipid antibody syndrome criteria: a single center study and literature review.

OBJECTIVE To determine the prevalence of anti-beta2-glycoprotein I antibodies (anti-beta2-GPI) in patients with systemic lupus erythematosus (SLE), and to assess their association with and predictive value for the clinical classification criteria of the antiphospholipid antibody syndrome (APS). METHODS One hundred thirty-three consecutive patients with SLE were recruited from 2 lupus clinics in the University of Toronto. Serum and plasma samples were tested for IgG anticardiolipin antibodies (aCL), prolonged partial thromboplastin time (PTT), a panel of lupus anticoagulant (LAC) assays, and anti-beta2-GPI (IgG, IgM, IgA). Normal ranges for the assays were established using 129 healthy controls. A literature review from 1992 to 2000 was performed using beta2-GPI, SLE, APS, thrombosis, and recurrent pregnancy loss as key search words. RESULTS The distribution of anti-beta2-GPI antibodies (of any isotype) in each group were as follows: all patients with SLE, 36.8%; SLE with clinical features of APS, 40.4%; SLE without clinical features of APS, 34.9%; and healthy controls, 3%. The positive predictive values of prolonged PTT, IgG aCL, and anti-beta2-GPI for at least one clinical feature of APS in SLE were 59.3, 50.0, and 38.8%, respectively. There were 27 patients with SLE who had antibodies to beta2-GPI but a normal PTT and negative aCL and LAC. Six (20.7%) of these had a history of thrombosis and/or recurrent pregnancy loss. Twelve studies (including ours) were identified in which patient groups were similar and the same antibody isotype was measured. No agreement was apparent after reviewing the literature regarding an association of anti-beta2-GPI IgG and clinical features of APS in patients with SLE. CONCLUSION Antibodies to beta2-GPI were frequently seen (35%) in our SLE population. The prevalence of anti-beta2-GPI was similar in those with (19/47) and without (39/86) APS. Anti-beta2-GPI did, however, identify 6 patients with clinical features of APS who were negative for aCL and prolonged PTT. Our results indicate that anti-beta2-GPI may provide additional information for the diagnosis of APS in SLE, but do not supercede other established assays. However, when we attempted to place our results in the context of other reports, the literature review revealed that secondary diagnoses of patient groups and assay techniques are too variable among different investigators to allow useful comparison. Thus, no conclusions could be drawn regarding anti-beta3-GPI and clinical features of secondary APS in SLE.
Image Resolution Enhancement Using NSCT with LBP as Feature Model

70 Image Resolution Enhancement using NSCT with LBP as Feature Model Patil Ashvini and Prof. S.P.Patil D.N. Patel College Of Engineering, Shahada Abstract—In this paper, we propose a new technique for feature preserving spatial resolution enhancement of an image captured at low spatial resolution. We use a training database containing low resolution (LR) images and their high resolution (HR) versions. In an image, different features like edges, corners, curves and junctions are important to convey its local geometry. We use Local Binary Pattern (LBP) operator to represent texture of an image. The missing high resolution details of the low resolution observation are learnt in form of Nonsubsampled Contourlet Transform (NSCT) coefficients of the high resolution images in the training database. We demonstrate the effectiveness of the proposed technique by conducting experiments on real world gray scale images. The results are compared with existing learningbased approaches. The proposed technique can be used in applications such as medical imaging, remote surveillance, wildlife sensor networks where the transmission bandwidth, the camera cost and the memory are main constraints.
The implications of strategic change of firm ownership on strategic positioning of Commercial Banks in Kenya

v CHAPTER ONE: INTRODUCTION 1 1.1 Background of the Study 1 1.1.1. Strategic Firm Ownership 2 1.1.2 Organizational Strategic Positioning 3 1.1.3 The Banking Industry In Kenya 5 1.1.4Commercial Banks In Kenya 6 1.2 Research Problem 7 1.3 Objective of the Study 9 1.4 Value of the Study 9 CHAPTER TWO: LITERATURE REVIEW 11 2.
Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer

Introduction: Epithelial ovarian cancer (EOC) is the second most common gynecologic malignancy and the leading cause of death from gynecologic cancer in the USA. EOC is an exquisitely chemo-sensitive disease with response rates of over 75% in the upfront setting. Despite this, due to high rates of recurrence and development of chemo-resistance, the overall survival of EOC remains about 25%. Thus, there is a great need for new therapeutic approaches to render more durable responses. Based on preclinical and early phase clinical studies, key targeted pathways include targets that drive angiogenesis and chemo-resistance. Receptor tyrosine kinases and non-receptor tyrosine kinases play important roles in these processes and several small molecule tyrosine kinase inhibitors (TKIs) are in clinical development. Areas covered: This review summarizes clinical rationale, mechanisms of action and clinical data for the TKIs under evaluation in the Phase III setting for EOC. Expert opinion: Despite reasonable preclinical activity, small molecule TKIs are unlikely to improve patient survival as single agent therapies in an unselected EOC population. Incorporation of tissue evaluation during ongoing clinical trials is required to identify molecularly defined groups that respond to single agents and direct rational combination strategies based on mechanisms of resistance to improve outcomes in EOC.
Usefulness of omega-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: a double-blind, randomized, placebo-controlled study.

AIM To assess the value of long-chain omega-3 fatty acids (FAs) supplementation in addition to amino-salicylic-acid (5-ASA) in pediatric patients with Crohn's disease (CD). METHODS Thirty-eight patients (20 males and 18 females, mean age 10.13 years, range 5-16 years) with CD in remission were randomized into two groups and treated for 12 mo. Group I (18 patients) received 5-ASA (50 mg/kg/d)+ omega-3 FAs as triglycerides in gastro-resistant capsules, 3 g/d (eicosapentanoic acid, EPA, 400 mg/g, docosahexaenoic acid, DHA, 200 mg/g). Group II (20 patients) received 5-ASA (50 mg/kg/d)+olive oil placebo capsules. Patients were evaluated for fatty acid incorporation in red blood cell membranes by gas chromatography at baseline 6 and 12 mo after the treatment. RESULTS The number of patients who relapsed at 1 year was significantly lower in group I than in group II (P<0.001). Patients in group I had a significant increase in the incorporation of EPA and DHA (P<0.001) and a decrease in the presence of arachidonic acids. CONCLUSION Enteric-coated omega-3 FAs in addition to treatment with 5-ASA are effective in maintaining remission of pediatric CD.
The herding behaviour and announcement of insider transfer trading: A study in Taiwan

ABSTRACT The present paper examines the influence of herding behaviour on the market response to insider transfer trades under different levels of ownership concentration. The results show that the three-day waiting period for executing insider transfer trades that is uniquely required in Taiwan makes investors hesitant to act immediately on this information in order to realise better returns after this three-day period. We found comparatively small negative abnormal returns on the day of the announcement and larger negative cumulative abnormal returns afterwards. Moreover, the financial industry, which has a higher level of ownership concentration, experienced larger negative accumulative abnormal returns under conditions of higher institutional sell herding
Guillain-Barré syndrome occurring during cortisone therapy.

The cause of the Guillain-Barre syndrome is still unknown. In the past the most widely held view was that the syndrome was caused by a neurotropic virus; this virus has not yet been identified and has not been transmitted. In recent years the reporting of various other causes has shown a swing in thought toward hypersensitivity as the cause of the syndrome, 1 as the pathological changes reported have been interpreted as more typical of hypersensitivity than of the acute inflammation of infection. 2 For this reason, several patients have been treated with corticotropin (ACTH) or cortisone with apparently good response, which was considered to indicate that the syndrome was based on allergy or hypersensitivity rather than on a direct infection of the central nervous system. 3 The assumption that a response to corticotropin or cortisone rules out an infectious basis is perhaps not valid. Certainly corticotropin or cortisone, while
From swot to value appropriation: Career implications

Meeks (2016) argues that while SWOT has been an important part of strategic analysis and strategy education, its usefulness has significantly diminished under ever-changing market conditions. He suggests that “such a model is inappropriate for our current dynamic marketplace, and should only be used as a cursory framework for elementary or preliminary analysis, and then only when its limitations are fully understood” (Meeks, 2016: 1). We agree with Meeks’ (2016) contention that SWOT be used with great caution.