Miracle-dz/UniFAR-FTUs huggingface dataset:
How We Approach Smoldering Multiple Myeloma

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.
Standalone Photovoltaic Direct Pumping in Urban Water Pressurized Networks with Energy Storage in Tanks or Batteries

Photovoltaic energy production is nowadays one of the hottest topics in the water industry as this green energy source is becoming more and more workable in countries like Spain, with high values of irradiance. In water pressurized systems supplying urban areas, they distribute energy consumption in pumps throughout the day, and it is not possible to supply electromechanical devices without energy storages such as batteries. Additionally, it is not possible to manage energy demand for water consumption. Researchers and practitioners have proven batteries to be reliable energy storage systems, and are undertaking many efforts to increase their performance, capacity, and useful life. Water pressurized networks incorporate tanks as devices used for accumulating water during low consumption hours while releasing it in peak hours. The compensation tanks work here as a mass and energy source in water pressurized networks supplied with photovoltaic arrays (not electricity grids). This work intends to compare which of these two energy storage systems are better and how to choose between them considering that these two systems involve running the network as a standalone pumping system without being connected to electricity grids. This work also calculates the intermediate results, considering both photovoltaic arrays and electricity grids for supplying electricity to pumping systems. We then analyzed these three cases in a synthetic network (used in earlier research) considering the effect of irradiation and water consumption, as we did not state which should be the most unfavorable month given that higher irradiance coincides with higher water consumption (i.e., during summer). Results show that there is no universal solution as energy consumption depends on the network features and that energy production depends very much on latitude. We based the portfolio of alternatives on investments for purchasing different equipment at present (batteries, pipelines, etc.) based on economic criteria so that the payback period is the indicator used for finding the best alternative, which is the one with the lowest value.
Endovascular Treatment of Totally Occluded Main Iliac Artery Using CO2 without Iodin- ated Contrast Medium

Periferik arter hastaları arasında; kronik böbrek hastalığı yaygın olarak görülür. Güncel kılavuzlar bu hastalarda endovasküler tedavi yöntemlerini ilk tedavi seçeneği olarak önermektedir. Kontrastın indüklediği nefropati önceden kronik renal hastalığı, kalp yetersziliği olan veya işlem öncesi dehidrate kalan hastalarda oldukça yaygın olarak görünür ve bu durum hastanede yatış süresini ve mortaliteyi artırmaktadır. Bu tür hastalarda CO2 alternatif bir contrast ajan olarak kullanılabilir ve diğer gazlardan farklı olarak hemen hemen tamamı hızlı bir şekilde absorbe edilir. Bu vaka bildirisinde kronik böbrek hastalığı (glomerular filtration rate of 24 ml/min/1.77 m2) olan sol ana iliak arteri tam tıkalı bir hastada; contrast ajan olarak CO2 in kullanıldığı bir vaka bildirilmiştir.
The Impact of Training Data Quality on Automated Content Scoring Performance

With the advent of advanced natural language processing methods and their application to evaluating constructed responses, automated scoring of content has rapidly become a potential alternative to human rating of constructed responses to prompts that measure specific content knowledge. In this paper, we conduct experiments using scored responses to almost 400 prompts collected from four different assessments in order to better understand how training data quality, particularly in terms of training sample size, Human-Human agreement (H-H agreement, i.e., the correlation between two independent human scores for the same prompt) and average response length, relate to system performance that is measured by Quadratic Weighted Kappa (QWK) between human ratings and machine predictions. Not surprisingly, we find that H-H agreement has a substantial impact on the system performance, though regardless of H-H agreement, increasing the training sample size improves the accuracy of the predictions. Our results can potentially provide additional helpful guidelines to researchers and practitioners about factors that most influence the performance of automated content-scoring
BIODIVERSITY, LABELLING AND OTHER ISSUES IN THE MARKETING OF GM PRODUCTS

Concerns with genetic engineering were first raised by a group of scientists at the Asilomar Conference in 1975 who called for measures to prevent the accidental release and proliferation of genetically modified bacteria outside the laboratory (Berg et al., 1975). This occurred soon after the technique of gene splicing or recombinant DNA was discovered by scientists working at Stanford University in the USA. The power of this technique lies in its ability to enable deoxyribonucleic acid (DNA), the chemical component of genes, from different sources to be combined to give rise to new forms of biologically functional entities. From this technique came modern biotechnology. The recombinant DNA technique has been variously termed genetic engineering, gene manipulation and genetic modification (GM). Ever since the first recombinant DNA ABSTRACT
An Automatic Diagnosis of Arrhythmias Using a Combination of CNN and LSTM Technology

Electrocardiogram (ECG) signal evaluation is routinely used in clinics as a significant diagnostic method for detecting arrhythmia. However, it is very labor intensive to externally evaluate ECG signals, due to their small amplitude. Using automated detection and classification methods in the clinic can assist doctors in making accurate and expeditious diagnoses of diseases. In this study, we developed a classification method for arrhythmia based on the combination of a convolutional neural network and long short-term memory, which was then used to diagnose eight ECG signals, including a normal sinus rhythm. The ECG data of the experiment were derived from the MIT-BIH arrhythmia database. The experimental method mainly consisted of two parts. The input data of the model were two-dimensional grayscale images converted from one-dimensional signals, and detection and classification of the input data was carried out using the combined model. The advantage of this method is that it does not require performing feature extraction or noise filtering on the ECG signal. The experimental results showed that the implemented method demonstrated high classification performance in terms of accuracy, specificity, and sensitivity equal to 99.01%, 99.57%, and 97.67%, respectively. Our proposed model can assist doctors in accurately detecting arrhythmia during routine ECG screening.
Investigation of Tissue Engineering Scaffolds for Potential Medical Applications

Article history: Received 15 August 2016 Accepted 27 November 2016 Available online 2 December 2016 Therapeutic stem cell transplantation bears the promise of new directions in organ and tissue replacement, but a number of its difficulties and perils are also well known. Our goal was to develop a method of transplantation by which the transplanted cells remain confined to the transplantation site and induce favorable processes.With the help of mask-projection excimer laser stereolithography, 3D hybrid nanoscaffolds were fabricated from biodegradable, photocurable PPF:DEF resin with incorporated gold nanoparticles (Au NPs). The scaffolds were tested in vitro and in vivo in order to find out about their biocompatibility and fitness for our purposes. In vitro, macrophages andmouse autologous adipose stem cells (ASCs)were seeded over the hybrid scaffolds and non-hybrid (with Au NPs) scaffolds for 4 days. The hybrid nanocomposite greater stem cell dispension and stem cell adhesion than PPF scaffolds without Au NPs, but such a difference was not seen in the case of macrophages. In vivo, stem cells, scaffoldings and scaffoldings covered in stem cells were transplanted under the back skin of mice. After 14 days, blood samples were taken and the affected skin area was excised. Cytokine and chemokine profiling did not indicate elevated immunomediators in the sera of experimental animals. Interestingly, the autologous-stem-cell-seeded hybrid nanocomposite scaffold induced muscle tissue regeneration after experimental wound generation in vivo. We could not observe such stem cell-induced tissue regeneration when no scaffolding was used. We conclude that PPF:DEF resin nanoscaffolds with incorporated gold nanoparticles offer a safe and efficient alternative for the enhancement of local tissue remodeling. The results also support the idea that adipose derived stem cells are an optimal cell type for the purposes of regenerative musculoskeletal tissue engineering. © 2016 Published by Elsevier B.V.
OPTH_A_234858 171..178

*These authors contributed equally to this work Introduction: Contrast rapid sequence angiography with fluorescein or indocyanine green (ICG) is a diagnostic procedure commonly used in ophthalmology. Adverse reactions to fluorescein and ICG are rare and may be classified as toxic, of hypersensitivity and nonspecific. The evaluation and management of a patient with an adverse reaction is a challenge for the majority of ophthalmologists, as is the assessment of risk factors that may contraindicate the procedure. Purpose: We aim to review the concepts underlying adverse reactions to fluorescein and ICG, especially those of hypersensitivity, and present a proposal or the evaluation of the patients in need to perform retinal angiography and for the treatment of immediate reactions to fluorescein and ICG. Methods: The available literature was examined using PubMed-Medline, and using the MeSH terms “fluorescein”, “Indocyanine green”, “ophthalmic dyes”, “retinal angiography”, “adverse reactions”, and “allergic reaction”. Conclusion: This review may help ophthalmologists to identify patients with higher risk of a hypersensitivity reaction and give them tools to recognize patients with suspected hypersensitivity that may benefit from an allergy study.
OTT_A_221643 381..387

Yu-Jie Wu Li-xia Li Lu Liu Si-shu Zhao Hai-rong Qiu Hui Wang 1 1Department of Hematology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People Hospital), Nanjing 210029, Jiangsu Province, People’s Republic of China; 2Department of Laboratory Medicine Center, The Second Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People Hospital), Nanjing 210011, Jiangsu Province, People’s Republic of China Background: Mixed lineage leukemia (MLL) fusion protein alone exhibits poor histone lysine methyltransferase (HKMT) activity in catalyzing histone H3 Lys4 trimethylation (H3K4me3) in MLL-rearranged acute leukemia. Methods: To explore the HKMT effect of another regulatory protein within the complex of proteins associated with Set 1 (COMPASS), we analyzed the H3K4me3 modification of the HOXC8 promoter under the action of ASH2L regulation. Small interfering RNA of ASH2L, chromatin immunoprecipitation, real-time-PCR (RT-PCR), and Western blotting were used to detect the expression of specific regions of the HOXC8 promoter, RBBP5, WDR5, MLL, and BRTF in two MLL-rearranged acute leukemia cell lines (RS4:11 and THP-1 cells). Results: The gene and protein expression levels of HOXC8 were significantly downregulated upon treatment with ASH2L-siRNA (as analyzed by targeting specific regions of the HOXC8 promoter located 0 and 3 kb (–3.0 kb) upstream of the transcriptional start site in RSH:11 cells; and –3.0 and –2.0 kb upstream of the transcriptional start site, and +1.4 kb downstream of the transcriptional start site in THP-1 cells). The expression levels of the BRTF, RBBP5,WDR5, and MLL genes were significantly downregulated from the different transcriptional start sites of the HOXC8 promoter in the RSH:11 cell line (P < 0.05). Furthermore, the BPTF and RBBP5 genes were downregulated from the HOXC8 promoter in the THP-1 cell line (P < 0.05). Conclusion: Based on these results, we suggest a new concept of histone modification of the ASH2L protein in MLL-rearranged acute leukemia, which cannot carry out methyltransferase activity independently. The protein–protein interactions of ASH2L with other COMPASS members, such as MLL, WDR5, RBBP5, and chromatin remodeling factor BRTF, appear to be essential for its role in the activation of HOXC8 gene transcription.
Training in visual skills improves a dyslexic Philippine child’s ability in reading and writing Japanese Kanji –characters

Using the case of a non-Japanese child showing severe difficulties in Kanji acquisition, this study empirically (1) investigated the cognitive properties hypothesized to be causing the child’s difficulties, by examining various potential cognitive disorders, and (2) developed and evaluated a support method, that is, the “Training in visual skills,” for learning Kanji based on the child’s cognitive properties. The results suggest that a foreign dyslexic child with difficulties in learning Japanese Kanji -characters can benefit from training in visual skills.
Spray-dried liposomes: A study of the effect of carbohydrate carrier and concentrations on liposome size and drug entrapment

Background and objective: Dry powder inhalation provide many promising features for drug delivery to the pulmonary system, such as localization of drug within the lungs, drug retention in the respiratory tract, and reduced systemic toxicities. This study aimed to prepare dry powders of liposomes containing salbutamol sulfate using spray drying and study the influence of carrier type and concentration on liposome size and drug entrapment following rehydration of liposomal powder. Methods: Ethanol based proliposomes technique was used to generate liposomes containing salbutamol sulfate. Carbohydrate carriers: lactose, trehalose, sucrose, and mannitol in 1:6 or 1:10 (w/w) lipid to carrier ratio were separately incorporated into liposome formulations and dried by Buchi Mini-SprayDryerB-290. The protective effects of the sugars were investigated in terms of product yield (%), volume median diameter and size distribution of liposomes and entrapment efficiency of the drug. Results: The product yield (%) of spray dried liposome formulations with carriers was in the following order; trehalose (94.02 ± 1.20%) > sucrose (69.91 ± 1.75%) > lactose (68.30 ± 1.14%) > mannitol (50.16±0.80%) for the 1:6 formulations. Depending on the carrier type and lipidto carrier ratio, the vesicle size of liposomes with lactose and mannitol increased significantly (P 0.05) compared to the control formulations (3.6µm ±0.24). For 1:10formulation, the vesicle size with mannitol (P <0.001) and sucrose (P <0.001) increased significantly. The drug entrapment efficiency using the 1:6 formulations was 20.74±1.78% for sucrose, 35.59±2.42% for trehalose, 67.21±1.89 % for lactose, and 80.84±3.64% for mannitol. Conclusion: Stable spray-dried liposomes were manufactured using sugars as carriers. The findings of this study have demonstrated the potential using of carbohydrate carriers to increase the physical stability of liposomes during the drying process, and trehalose can offer formulations with most desirable characteristics, while mannitol showed the least benefits.
Investigating the Institutional Investment And its Effect on Stock Price Falling Risk in Accepted Companies of Tehran Stock Exchange

This research aims to investigate the relationship between institutional investors and stock price falling risk. From the perspective of relationship between variables this research is scientific, and an applied one according to the objective. To test the research hypotheses panel data method has been implemented in order to estimate the model and population; regarding the implemented counting, data of 107 companies during 2007 to 2013 was used. Descriptive data analysis has been implemented for the obtained data of this research and it has been conducted applying post-event approach (through past data). On the descriptive level, general features of the population have been dealt with using statistical characteristics and on the inferential level regression analysis test, significance t-test, and significance F test have been applied in order to respond research hypotheses and to find special relationships between population variables. Also, hypotheses test has been implemented using Eviews 9 statistical software. Results indicated that there is a significant relationship between temporary institutional owners, proprietary institutional owners,institutional owners' fluctuations, and stock price falling risk.
Guillen-Barret Syndrome in a Patient with Leptospirosis

Introduction: leptospirosis is a zoonotic infection which is mostly transmitted with infected water. We report a case of Guillen-barret syndrome in adults associated with leptospirosis infection. Case Description: A 59 years old, worker of water and Sewage Company, presented to emergency room with icter, ascending paraplegia and high creatinine level. He reported influenza like symptoms 2 weeks before his current presentation. Due to his work status and symptoms, leptospirosis infection was considered and patient received doxycycline in his treatment coarse. Patients symptoms and lab test has been better however weakness and reduced DTR was persistent. Cervical spine MRI reveals disc dehydration and protrusion in C5-6. However his symptoms, due to reducing DTR and ascending weakness were more consistent with Guillen batter syndrome. The patient received IVIG and the symptoms significantly reduced. Discussion: Based on literature, the most common neurologic manifestation of leptospirosis is aseptic meningitis however there are some reports of mononeuritis multiplex, flaccid paraplegia and a Guillen-barret in pediatric. Our case is the first report of Guillen-barret in an adult with leptospirosis.
First record of Navicula pelagica (Bacillariophyta) in the South Atlantic Ocean: the intriguing occurrence of a sea-ice-dwelling species in a tropical estuary

Despite the wide distribution of species of the genus Navicula in the most diverse habitats around the globe, Navicula pelagica Cleve (Bacillariophyceae) is reported almost exclusively as one of the main components of the diatom biota of Arctic sea-ice. The present study is the first record of N. pelagica in the South Atlantic Ocean (Brazil) and demonstrates an ecological niche model of the species. The analyzed specimens were rectangular, with rounded angles in pleural view, the pervalvar axis measured 7.9-9. 5μm and the apical axis 22-25μm, an evident central nucleus and two comma-shaped chloroplasts, one on each side of the nucleus, were observed. The specimens formed chains of 35 cells, on average, arranged in the typical pattern of rotation about the chain axis relative to their neighboring cell. The applied ecological niche model indicated that the Brazilian coast has low environmental suitability (~12%) for the development of N. pelagica. Our hypothesis is that its occurrence in this tropical environment was due to transport and discharge of ballast water. Further studies are needed with the objective of monitoring this species in the Camamu Bay, considering that even ecosystems that are only minimally suitable for non-indigenous species are potentially vulnerable to invasion.
Modified cyclodextrins as broad-spectrum antivirals

Sulfonated cyclodextrins show nontoxic, broad-spectrum virucidal activity in vitro, ex vivo, and in vivo. Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed nontoxic, broad-spectrum virucidal gold nanoparticles. Here, we develop further the concept and describe cyclodextrins, modified with mercaptoundecane sulfonic acids, to mimic heparan sulfates and to provide the key nontoxic virucidal action. We show that the resulting macromolecules are broad-spectrum, biocompatible, and virucidal at micromolar concentrations in vitro against many viruses [including herpes simplex virus (HSV), respiratory syncytial virus (RSV), dengue virus, and Zika virus]. They are effective ex vivo against both laboratory and clinical strains of RSV and HSV-2 in respiratory and vaginal tissue culture models, respectively. Additionally, they are effective when administrated in mice before intravaginal HSV-2 inoculation. Lastly, they pass a mutation resistance test that the currently available anti-HSV drug (acyclovir) fails.
Retinal Mosaicking with Vascular Bifurcations Detected on Vessel Mask by a Convolutional Network

Mosaicking of retinal images is potentially useful for ophthalmologists and computer-aided diagnostic schemes. Vascular bifurcations can be used as features for matching and stitching of retinal images. A fully convolutional network model is employed to segment vascular structures in retinal images to detect vascular bifurcations. Then, bifurcations are extracted as feature points on the vascular mask by a robust and efficient approach. Transformation parameters for stitching can be estimated from the correspondence of vascular bifurcations. The proposed feature detection and mosaic method is evaluated on retinal images of 14 different eyes, 62 retinal images. The proposed method achieves a considerably higher average recall rate of matching for paired images compared with speeded-up robust features and scale-invariant feature transform. The running time of our method was also lower than other methods. Results produced by the proposed method superior to that of AutoStitch, photomerge function in Photoshop cs6 and ICE, demonstrate that accurate matching of detected vascular bifurcations could lead to high-quality mosaic of retinal images.
Effect of Internal Control Indices on Innovation of Employees at Melli Bank in Zanjan, Iran

The development of internal control systems for optimal management of employees’ activities is an effective factor in promoting innovations at banks. The internal control system is a process which is used by organization to achieve its goals and plays an important role in ensuring the success of organization in achieving goals. However, this study aimed to investigate the effect of internal control indices on promotion of innovation among employees at Melli Bank in Zanjan. This was descriptive-analytic study. The field studies and library were used to collect data. The population consisted of all employees at Melli Bank in Zanjan. Using Cochran formula and stratified random sampling method, 215 employees were selected as sample. A researcher-made standard questionnaire was used for collecting the data. Using SPSS software, the descriptive statistics, linear regression test, and normal distribution test (skewness coefficient) were used for analyzing the data. However, the findings showed that the mean of internal control index was 3.38 and the mean of innovation index was 4.39; the sample believed that the importance of internal control was more than innovation. Also, the linear regression test showed that the correlation coefficient between self-control and innovation was 0.225; since the significance value was less than 5%, it can be said that there was a direct and significant correlation between self-control and innovation (error level= 5%). Considering the findings, it was concluded that the participatory management, formulation of delegation principles, and ethical-training courses were necessary to improve the performance of banks.