Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural and genetic correlates of antidepressant response to sleep deprivation: a functional magnetic resonance imaging study of moral valence decision in bipolar depression.

CONTEXT Total sleep deprivation combined with light therapy causes rapid amelioration of bipolar depression. A polymorphism in the promoter for the serotonin transporter influences both antidepressant response and the structure and function of specific brain areas. OBJECTIVE To determine whether antidepressant therapy or the genotype of the serotonin transporter influence the pattern of neural response to a task targeting the depressive biases in information processing (moral valence decision). DESIGN Before-and-after trial studying the biologic correlates of response to treatment. SETTING University hospital. Patients Twenty inpatients with bipolar depression. Intervention Repeated total sleep deprivation combined with light therapy for 1 week. MAIN OUTCOME MEASURES Brain blood oxygen level-dependent functional magnetic resonance imaging using a 3.0-T scanner before and after treatment. Self-ratings and observer ratings of mood (visual analog scale 3 times daily and Hamilton Depression Rating Scale) before and after treatment. RESULTS We found significant interactions of treatment (before and after), response to treatment (Hamilton Depression Rating Scale score <8), and moral valence of the stimuli (positive or negative) in the anterior cingulate cortex, dorsolateral prefrontal cortex, insula, and parietal cortex. In these areas, responders changed their blood oxygen level-dependent responses to emotional stimuli in a pattern opposite of that in nonresponders. Genotype of the promoter for the serotonin transporter predicted response to treatment and influenced baseline neural responses in the anterior cingulate cortex and the dorsolateral prefrontal cortex. CONCLUSION Multiple factors that affect or are affected at the individual level by major depressive episodes in the course of bipolar disorder significantly interact in influencing brain cortical activity in specific areas.
A Sm‐like protein complex that participates in mRNA degradation

In eukaryotes, seven Sm proteins bind to the U1, U2, U4 and U5 spliceosomal snRNAs while seven Smlike proteins (Lsm2p–Lsm8p) are associated with U6 snRNA. Another yeast Sm‐like protein, Lsm1p, does not interact with U6 snRNA. Surprisingly, using the tandem affinity purification (TAP) method, we identified Lsm1p among the subunits associated with Lsm3p. Coprecipitation experiments demonstrated that Lsm1p, together with Lsm2p–Lsm7p, forms a new sevensubunit complex. We purified the two related Sm‐like protein complexes and identified the proteins recovered in the purified preparations by mass spectrometry. This confirmed the association of the Lsm2p–Lsm8p complex with U6 snRNA. In contrast, the Lsm1p–Lsm7p complex is associated with Pat1p and Xrn1p exoribonuclease, suggesting a role in mRNA degradation. Deletions of LSM1, 6, 7 and PAT1 genes increased the half‐life of reporter mRNAs. Interestingly, accumulating mRNAs were capped, suggesting a block in mRNA decay at the decapping step. These results indicate the involvement of a new conserved Sm‐like protein complex and a new factor, Pat1p, in mRNA degradation and suggest a physical connection between decapping and exonuclease trimming.
Direct v/s Indirect sinus lift in maxillary dental implants

Introduction: Lack of sufficient bone height along maxillary sinus poses significant difficulty for placement of implants in edentulous maxillary jaw. Minimally invasive sinus augmentation is an effective solution for this problem. The manuscript intends to present long period results of such augmentation using direct (DSAT) and indirect (ISAT) minimally invasive sinus augmentation technique (SAT) from a single center. Materials and Methods: Records of patients who required minimally invasive sinus augmentation to increase residual bone height for implant placement fulfilling predetermined exclusion and inclusion criteria. Only patients with follow-up records for at least a year were considered. Both DSAT and ISAT were employed for sinus augmentation. The age, gender, period of edentulousness, alveolus thickness at crestal level during the pre- and postoperative assessment, implant length, and diameter of implants were collected from case histories. Descriptive statistics, Chi-square, paired test, and one way analysis of variance (ANOVA) was used appropriately. P ≤ 0.05 was considered as significant. Results: There were 197 implants placed and mean age of the group was 40.2 ± 10.7 years. There was a slight male predilection (54.3%). The gain in bone height as expressed in percentage after a year was 134.6%. On comparing the length of residual alveolar bone (RAB) at start and end of study, ISAT had a mean preoperative height of 7.88 mm while postoperative height was 13.22 mm. For DSAT, the mean height at start of treatment was 3.94 mm while at the end it was 10.13 mm. The mean increase in height was 6.19 mm. For both cases, P was 0.000. Discussion: Age, gender, and period of edentulism did not influence the outcome. The alveolar width appears to differ and influence the outcome. When alveolar width increases, wider diameter implants can be placed by compromising height. Thus it is a clinical acumen that would be extremely helpful to gauge the outcome of the condition.
Detection of network communities with memory-biased random walk algorithms

Community structure and its detection in complex networks has been the subject of many studies in the recent years. Towards this goal, we have created a novel approach based on the analysis of the motion of a memory-biased random walker, i.e. an entity that traverses the network with some tendency to follow or avoid pathways it has previously traversed. We found that the walker tends to remain inside communities, that is, subsets of the network nodes which are more connected to each other, rather than to the rest of the network. Based on this trait of the MBRW we developed a method to detect communities and tested its performance on a range of networks with different levels of community structure. In all tested cases, the method proved to be at least as effective as Girvan–Newman or Infomap while outperforming them when communities were less well defined.
Language-independent Model for Machine Translation Evaluation with Reinforced Factors

The conventional machine translation evaluation metrics tend to perform well on certain language pairs but weak on other language pairs. Furthermore, some evaluation metrics could only work on certain language pairs not language-independent. Finally, no considering of linguistic information usually leads the metrics result in low correlation with human judgments while too many linguistic features or external resources make the metrics complicated and difficult in replicability. To address these problems, a novel language-independent evaluation metric is proposed in this work with enhanced factors and optional linguistic information (part-of-speech, n-grammar) but not very much. To make the metric perform well on different language pairs, extensive factors are designed to reflect the translation quality and the assigned parameter weights are tunable according to the special characteristics of focused language pairs. Experiments show that this novel evaluation metric yields better performances compared with several classic evaluation metrics (including BLEU, TER and METEOR) and two state-of-the-art ones including ROSE and MPF.
Dynamic electrocardiographic changes in patients with arrhythmogenic right ventricular cardiomyopathy

Background and objectives Electrocardiographic (ECG) abnormalities of depolarisation and repolarisation contribute to the diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC). The development of diagnostic ECG features were investigated in a genotyped cohort with ARVC to provide more sensitive markers of early disease. Methods T-wave inversion (TWI) in right precordial leads, epsilon waves, localised QRS prolongation greater than 110 ms in V1–V3 and QRS dispersion greater than 40 ms were analysed from 317 ECG from 68 genotyped patients (34 with disease-causing mutations) during follow-up of 34±28 months. Results 16 patients (23%) had changes during follow-up, with the appearance of new ECG abnormalities in seven (10%) and dynamic changes in nine (13%). Four developed new and persistent TWI and eight had dynamic TWI in right precordial leads. Three developed new and another three had dynamic epsilon waves. No changes were observed in 10 with and 58 patients without localised QRS prolongation and in six patients with and 61 without QRS dispersion greater than 40 ms. An additional patient with QRS dispersion at baseline had normal depolarisation dispersion during follow-up. None of the nine ARVC patients with dynamic ECG changes had major structural or functional right ventricular abnormalities, suggesting an early stage of the disease. Conclusions New or dynamic ECG changes were observed in 23%. This underscores the importance of serial ECG in the diagnosis of individuals at risk of ARVC, in whom potentially lethal arrhythmia may develop before major abnormalities are detectable with conventional imaging.
Neonatal origins of schizophrenia

Schizophrenia is not an illness which impinges much upon the daily practice of paediatricians or, indeed, child psychiatrists, as only a tiny proportion of diagnosed cases (< 5%) arise before the age of 16 years.1 Schizophrenia is one of the few chronic diseases which arise principally during late adolescence and early adulthood, normally the healthiest period of life. There is increasing evidence, however, that neurodevelopmental factors, acting in utero and in early childhood, are important in determining the risk for later schizophrenia.2 3 #### Key messages There is no doubt that genetic factors are involved in the aetiology of schizophrenia.4 First degree relatives of patients have a morbid risk of developing schizophrenia which is eight to 10 times higher than the risk in the general population; this risk rises to approximately 50% in the identical twins of schizophrenics. Now that a neurodevelopmental aetiological model is considered most likely, genes that control early development have come under particular suspicion. Unfortunately, in spite of an intensive effort to locate and identify susceptibility genes for schizophrenia, none has yet been found.5 The fact that the monozygotic concordance rate for schizophrenia is only 50% indicates that environmental factors must also be involved, and simple additive models suggest that between …
Paternal Postnatal Depression - a review

Objective. Among the factors responsible for the occurrence of paternal postnatal depression, the following are the most frequent: biological factors (mainly hormonal changes), mental pathogens (mainly a specific personal profile, including neuroticism, perfectionism and obsessiveness, mental disorders and problems such as fear, anxiety or mental disorders, marital coincidence of depression, a high level of stress experienced and lower quality of sexual life in the postpartum period), and finally – socioeconomic status (mainly poverty, young age of the spouse, his low level of education and structural problems in the family). However, it should be noticed that the subject of paternal postnatal depression is relatively rarely taken up in research or discussed in specialist magazines. Conclusions. However, due to the fact that postnatal depression, both in mothers and in fathers, greatly impacts the life of the child and the functioning of the family, it seems that this area of research is of crucial importance. The identification of risk factors of depression in new fathers may not only lead to a more profound understanding and description of the ethiology and symptomatology of paternal postnatal depression, but also to distinguishing a risk group in order to provide it with professional prophylactic and therapeutic care.
Establishing Crime Prevention Systems based on Internet of Things and Associated Spatial Urban Factors

This study was conducted in the basis of a hypothesis that there is a positive correlation between crime and spatial urban factors. This study also concretely describes and summarizes those associated factors. In order to prove the hypothesis, actual criminal cases were extensively reviewed, and this study aims to describe proven urban environmental factors can be evaded by recognizing their precursors via IoT. As an analysis result, it is also verified that IoT technologies can provide the risk prediction of pedestrian’s routes
Using Information Technology for Active Learning in International Business Education

The purpose of this study was to examine the impact of information technology (IT) in international business education. Results indicated that incorporating such technology in the pedagogy and course curriculum facilitated active learning for the students and augmented faculty performance. Specifically, IT helped the faculty develop innovations, assess students better and increase classroom management skills. In addition, it enhanced student-student and student-faculty communication and collaboration, and improved students’ access to information. However, contrary to popular belief, usage of technology did not improve students’ analytical and problem solving skills.
A report on soap making in Nigeria using indigenous technology and raw materials

In everyday life we use soap to wash dishes, clean clothes, or keep our bodies presentable to nose and eye. Soap therefore has numerous applications in our daily life. One of its great values is keeping our household a far better place to live and work. However, contrary to what one may think, soap was invented not only for the purpose of personal hygiene; rather, it was invented to solve other purposes. Colourful yarns were valued very early in the history of textiles; wool as it comes from the sheep is coated with a layer of grease that interferes with the application of dyes, soap was used to solve this problem. This report attempts to explore the technology of soap production in Nigeria using indigenous raw materials. Key words: Soap, raw materials, technology, chemistry, quality control.
Potential Uses and Usefulness of Italian Local Government Consolidated Financial Reporting: The Case of the Town Council of Brescia

Debate on consolidated financial reporting has considerably increased over the years, also due to the various public sector accounting reforms. In this regard, Italy offers an important experience since it was one of the first countries in the European Union to expressly provide for compulsory adoption. The Legislative Decree no. 118/2011 will introduce consolidated financial reporting for local government as from 2017, after an initial “experimentation” period. In view of the recent adoption, the methodological approach implemented in the chapter is based on a case study. After discussion of the boundaries of the consolidation performed by comparison with international experiences – IPSAS 6, new IPSAS 35 and GASB 14 – a critical analysis of the Italian proposal is also provided. The chapter aims to contribute to the debate on consolidated financial reporting both from the theoretical and empirical points of view.
Understanding the alloresponse: new approaches to graft-versus-host disease prevention.

Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of allogeneic bone marrow transplantation (BMT). GVHD occurs when donor T cells react to host antigens on antigen-presenting cells (APCs) and attack host tissues, with sequential activation of donor T cells and monocytes/macrophages. The net effects of dysregulated cytokine production in this complex system are the severe inflammatory manifestations that we recognize as clinical acute GVHD. Long-term outcomes are also adversely affected by chronic GVHD, which has distinctive clinical and pathologic manifestations that mimic autoimmune disease, although its exact pathogenesis remains ambiguous. The ultimate goal for preventing GVHD is the induction of specific tolerance to host antigens, thereby maintaining favorable aspects of donor immunity. Tolerance may be achieved by costimulatory blockade, deletion of activated cells, suppression by regulatory T cells, and immune deviation. This report will focus on these mechanisms as they relate to the pathophysiology of acute GVHD.
CHANGES IN BUDGETING

One of the most important issues for companies is how to implement their strategies. Companies implement strategies in a number of ways. Budgeting is described in academia as well as in practice as the corner stone of the management control process through which strategies are implemented. Almost all companies have a budgeting process central to their strategic plans. Yet the usefulness of budgets has generated much criticism and debate in recent years. Many business owners and managers are dissatisfied with budgets. A novel approach is proposed in the literature to displace classical budgeting. This novel approach is termed “Beyond Budgeting. ” The first part of the paper reviews the challenges that traditional planning and budgeting presents to companies. The second part discusses the novel approach to budgeting. The third part provides examples of companies budgeting practices. The fourth part presents the conditions for a successful implementation of the novel approach.
Tooth Contact During Chewing

THE main justification for the treatment known as bite rehabilitation or locclusal equilibration appears to be the assumption that the teeth come into centric ocelusal contact during chewing. If this occurs and if the occlusion is normal, the masticatory loads are distributed (not necessarily equally) throughout the whole dental arch. If the teeth do not come into contact during chewing, but remain separated by food, then ocelusal equilibration seems to be justified only in gross malposition of the teeth, or in individuals who indulge in bruxism. The problem of ocelusal contact during chewing has been investigated by only a few workers. Hildebrand,' using radiographic technics, concluded that at the commencement of the chewing movement there is slight lateral gliding of the lower denture against the upper, and at the termination of the movement "the mandible reaches the ocelusal position after eventual gliding of the lower denture against the upper. " Jankelson, Hoffman and Hendron' reported results obtained by completing an electrical circuit between opposing teeth, which showed that contact during chewing did not occur or was insignificant. In some instances it appeared at the first swallow, in others only during the second or third swallow. The record shown in their paper was obtained from one subject eating apple. Yurkstas and Emerson,3 using a similar technic on 12 subjects with artificial dentures showed a surprising frequency of tooth contact both on the working and balancing sides. The subjects chewed meat and bread sandwiches. The series of experiments to be reported here was designed to investigate the frequency of tooth contact in the natural dentition during chewing. Ten male subjects of ages ranging between 20 and 34 years provided the experimental data. All except one (Subject 1) were student volunteers, who were not chosen on the basis of their dental condition; the only requirement being the presence of amalgam restorations in one pair of opposing posterior teeth. In all cases the dentition was complete or nearly so.
Biomedicine. Stem cell recipe offers diabetes hope.

Douglas Melton is as impatient as anyone for a cure for diabetes. His son developed the disease as an infant, and his daughter was diagnosed at age 14. For most of the past 2 decades, the developmental biologist at the Harvard Stem Cell Institute has focused his research on finding a cure. This week, he and his colleagues report a potentially significant step toward that goal: a recipe that can turn human stem cells into functional pancreatic β cells—the cells that are destroyed by an autoimmune attack in type 1 diabetes patients such as Melton9s son and daughter. The cells his group made respond to glucose by producing insulin, just as normal β cells do. And when implanted into mice with a form of diabetes, the cells can cure the disorder. The lab-generated cells should be a valuable tool for studying diabetes and, Melton hopes, could eventually be used to treat patients.
Misexpression of Dickkopf‐1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification

Developing cartilage serves as a template for long‐bone development during endochondral ossification. Although the coupling of cartilage and bone development with angiogenesis is an important regulatory step for endochondral ossification, the molecular mechanisms are poorly understood. One possible mechanism involves the action of Dickkopf (DKK), which is a family of soluble canonical Wnt antagonists with four members (DKK1–4). We initially observed opposite expression patterns of Dkk1 and Dkk2 during angiogenesis and chondrocyte differentiation: downregulation of Dkk1 and upregulation of Dkk2. We examined the in vivo role of Dkk1 and Dkk2 in linking cartilage/bone development and angiogenesis by generating transgenic (TG) mice that specifically express Dkk1 or Dkk2 in chondrocytes, hypertrophic chondrocytes, or endothelial cells. Despite specific expression pattern during cartilage development, chondrocyte‐ and hypertrophic chondrocyte‐specific Dkk1 and Dkk2 TG mice showed normal developmental phenotypes. However, Dkk1 misexpression in endothelial cells resulted in defects of endochondral ossification and reduced skeletal size. The defects are caused by the inhibition of angiogenesis in developing bone and subsequent inhibition of apoptosis of hypertrophic chondrocytes and cartilage resorption. © 2012 American Society for Bone and Mineral Research.
Derivation of SystemC code from abstract system models

Formal methods provide techniques and tools for constructing models of software systems and more generally of hardware/software systems. Mathematical models are incrementally developed and provide informations validated by proof assistant; the development starts by a simple model and the process enriches current models by adding details from the requirements; the process leads to a sequence of models related by the refinement relation and a sequence of directed acyclic graphs stating dependency among parameters to be computed by the future monitoring tool. Those DAGs together with the events of models, can be used to generate an architecture of the final system and a code for computing each parameter. The resulting architecture and the resulting code are produced from formally validated components; moreover, DAGs help in the organization of computations among parameters. Our work shows how formal models and DAGs can be used to build a system on chip using SystemC.
CREATION OF SPATIAL INFORMATION DATABASE FOR APPRAISING THE REAL ESTATE

Up to now real estate appraisers have appraised real estate based on their intuition or experiences. Now that the concern with securitization of real estate is brought to attention, the technique of appraising the real estate more logically, quantitatively and accurately is required. In the course of time several studies have been made on calculating the risk or proper price of real estate by applying usual financial technology to this field. It has been recognized that the price of real estate depends on the micro-level condition. Therefore, investigation not only considering simple geographical elements in what distance estate is located from the main stations of railroad but a spot surveys and appraisals have been important. Now, the spatial information data including various attributes has been arranged so much. Then, in this research, they are collected and it aims at creating the spatial infomation database for performing more rational evaluation of real estate value so much and quickly. After achieving this purpose, there is very big impact in securitization of real estate, etc.