Miracle-dz/UniFAR-FTUs huggingface dataset:
Ferulic Acid and its Position Among the Phenolic Compounds of Wheat

Ferulic acid (3-methoxy-4-hydroxycinnamic acid) is the main phenolic acid occurring in cell walls of monocotyledones. Due to its blue-and-white fluorescence it is easily identified and is located in the cereal grain morphological parts. Its 40-fold greater concentration was found in the cells walls of the seed coat and aleuronic layer than in the cells walls of endosperm. Most often, it is linked by ester bonds with hemicellulose chains, mainly with arabinose residues and it also polymerizes with lignin through ether bonds. However, ferulic acid in the pentosane molecules forms specific complexes with proteins through chemical bonds with amino acids. It is interesting to mention the theory of the pentosane gel formation in which a great role is assigned to ferulic acid. An oxidized form of ferulic acid—diferulic acid—produces gel formation by linking two pentosane or protein molecules. The blue-and-white fluorescence of ferulic acid can be applied to determine flour contamination with grain coat particles and its ability to form complexes with pentosanes and proteins is important in the formation of dough texture with its semi-elastic properties.
Gamma radiation fluctuations during alternative healing therapy.

CONTEXT The actual identification (let alone measurement) of "healing energy" has been elusive and controversial. Although healing energy has been defined as "subtle" and "undetectable," preliminary research indicates that these descriptions may be inaccurate. OBJECTIVE To assess the fluctuation of extremely high-frequency electromagnetic fields, or gamma rays, during Polarity therapy treatment. DESIGN A series of gamma detection rate experiments were performed to establish a background and baseline count rate among 10 treatment and 20 control (10 sham and 10 standing-observer) subjects. SETTING The Columbus Polarity Therapy Institute in Columbus, Ohio, and Public Health Information Services, Inc, in Dublin, Ohio. PARTICIPANTS 30 volunteers recruited from Polarity and nonparticipant groups. INTERVENTION Polarity therapy, a holistic bioenergy modality. MAIN OUTCOME MEASURES The detection rate at 4 anatomical locations in space relative to each subject's body was measured using an Nal(Tl) gamma radiation detector operated in integral count mode. RESULTS Marked decreases in gamma counts were found at every anatomical site location for all subjects during Polarity therapy, with less change noted during the standing-observer and sham sessions. Gamma radiation decreased in 100% of subjects during therapy sessions at every body site tested, regardless of which therapist performed the treatment. CONCLUSIONS This preliminary study suggests a consistent and dramatic decrease in the number of gamma rays measured in a subject's electromagnetic field during one type of alternative healing energy treatment (Polarity therapy). The authors strongly recommend the collection of additional data, especially on subjects with cancer, whose long-term survival might be enhanced as a result of the radiation hormesis effects of alternative energy therapies.
Effects of Child Sexual Abuse on the Parenting of Male Survivors

Research shows that child sexual abuse (CSA) can have detrimental effects on adult functioning. While much research regarding the effects of CSA on parenting of mothers is available, there is a dearth of information on how CSA impacts fatherhood. This literature review finds that the parenting experiences of male survivors are characterized by self-perceptions as adequate parents, deficient parenting as measured by standardized instruments, conceptualization of parenting as an intergenerational legacy and potential healing experience, fear of becoming an abuser, and physical and emotional distance from their children. These themes are strongly related to social discourses on intergenerational cycle of violence theories. Fatherhood is not exclusively problematic for male survivors and can be a healing experience and a source of strength for some survivors. Based on literature concerning male survivors who are parents, narrative therapy is recommended as a therapeutic model to explore how fathers who are survivors challenge dominant discourses around legacies of family violence, intergenerational parenting deficiencies, and victimization. Restorying fatherhood as a healing opportunity is essential when working with fathers who are male survivors and their families.
Investor Sentiment, Profitability and Offer Price Band: Evidence from the Indian IPO Market

Offer price band is a crucial component of the book building process in the Initial Public Offering process of a firm. Extant research shows that investor sentiment plays a prominent role in IPO markets. We therefore suggest that investor sentiment plays a significant role in determining the offer price range. The determinants of offer price band have not been studied in the IPO literature. We fill this lacuna by studying the Indian IPO market. We hypothesise that investor sentiment will positively influence offer price band. We also posit that the profitability of a firm will be inversely related to the offer price band. Our empirical tests support these hypotheses.
Crystal Structure of TruD, a Novel Pseudouridine Synthase with a New Protein Fold*

TruD, a recently discovered novel pseudouridine synthase in Escherichia coli, is responsible for modifying uridine13 in tRNAGlu to pseudouridine. It has little sequence homology with the other 10 pseudouridine synthases in E. coli which themselves have been grouped into four related protein families. Crystal structure determination of TruD revealed a two domain structure consisting of a catalytic domain that differs in sequence but is structurally very similar to the catalytic domain of other pseudouridine synthases and a second large domain (149 amino acids, 43% of total) with a novel α/β fold that up to now has not been found in any other protein.
Cycling Exercise Training Alleviates Hypoxia-Impaired Erythrocyte Rheology.

PURPOSE Physical exercise or hypoxic exposure influences hemorheology and acid-base homeostasis. Band 3 protein in erythrocytes modulates cells' rheological properties and anion transport ability. This study investigated how cycling aerobic interval training (AIT) and moderate continuous training (MCT) affect the rheological function and band 3 activity of erythrocytes under hypoxic exercise (HE) stress. METHODS Forty-five healthy sedentary men were randomized to engage in either AIT (3-min intervals at 40% and 80% of VO2max, n = 15) or MCT (sustained 60% of VO2max, n = 15) on a bicycle ergometer for 30 min · d(-1) (5 d · wk(-1) for 5 wk) or to a control group that did not perform any exercise (n = 15). Erythrocyte rheological responses to HE (100 W under 12% O2 for 30 min) were determined before and after various regimens. RESULTS Acute HE increased the aggregation and osmotic fragility of erythrocytes, decreased the deformability of erythrocytes, and depressed erythrocyte band 3 activity, as indicated by lowered anion transport ability. Following 5 wk of intervention, the AIT group exhibited maximal work rate and VO2max higher than those in the MCT and control groups. Moreover, cycling AIT and MCT diminished the extent of erythrocytes' enhanced aggregation and osmotic fragility and reduced their deformability and band 3 activity caused by HE. Additionally, erythrocyte band 3 activity was directly related to erythrocyte deformability and inversely related to erythrocyte aggregation and osmotic fragility. CONCLUSIONS Cycling AIT is superior to cycling MCT in enhancing aerobic capacity. Moreover, either cycling AIT or MCT effectively alleviates HE-evoked impairments of erythrocyte rheological characteristics and band 3 function.
An integrated approach to the study of the venous system with steps toward a detailed model of the dynamics of venous return to the right heart.

We attempt to define, in terms familiar to engineers, physicists, and workers in the life sciences, the uncontrolled mechanical system returning venous blood to the right heart. Our ultimate aim is to complete a description of the venous circulation useful to close the loop with current models of the arterial circulation and the heart. Such a detailed global circulatory model will incorporate eventually enough control theory to render insight into basic regulatory mechanisms of man in health and disease. Only a multidisciplinary approach can lead to this ultimate objective.
Selection via Scaling Factor Integrated Multi-Class Support Vector Machines

In data mining, we often encounter high dimensional and noisy features, which may not only increase the load of computational resources but also result in the problem of model overfitting. Feature selection is often adopted to address this issue. In this paper, we propose a novel feature selection method based on multi-class SVM, which introduces the scaling factor with a flexible parameter to renewedly adjust the distribution of feature weights and select the most discriminative features. Concretely, the proposed method designs a scaling factor with p2 power to control the distribution of weights adaptively and search optimal sparsity of weighting matrix. In addition, to solve the proposed model, we provide an alternative and iterative optimization method. It not only makes solutions of weighting matrix and scaling factor independently, but also provides a better way to address the problem of solving `2,0-norm. Comprehensive experiments are conducted on six datasets to demonstrate that this work can obtain better performance compared with a number of existing state-of-the-art multi-class feature selection methods.
Vaginal Cytology of the Laboratory Rat and Mouse

Microscopic evaluation of the types of cells present in vaginal smears has long been used to document the stages of the estrous cycle in laboratory rats and mice and as an index of the functional status of the hypothalamic–pituitary–ovarian axis. The estrous cycle is generally divided into the four stages of proestrus, estrus, metestrus, and diestrus. On cytological evaluation, these stages are defined by the absence, presence, or proportion of 4 basic cell types as well as by the cell density and arrangement of the cells on the slide. Multiple references regarding the cytology of the rat and mouse estrous cycle are available. Many contemporary references and studies, however, have relatively abbreviated definitions of the stages, are in reference to direct wet mount preparations, or lack comprehensive illustrations. This has led to ambiguity and, in some cases, a loss of appreciation for the encountered nuances of dividing a steadily moving cycle into 4 stages. The aim of this review is to provide a detailed description, discussion, and illustration of vaginal cytology of the rat and mouse estrous cycle as it appears on smears stained with metachromatic stains.
Infrastructure, the crisis, and pension funds

Infrastructure investment has been an important element in the economic stimulus packages introduced to try and deal with the effects of the recession. It is reinforced by the need to develop sustainable energy sources, and by the development needs of countries in the south. Public sector finance – tax revenues and bonds – remain the main way of financing such investment. The use of PPP projects to finance and operate infrastructure services, and the development of infrastructure funds as a way of investing in them, are both dangerous and unnecessary.
Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response*

The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeast Saccharomyces cerevisiae were isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.
Relationship between palato-radicular grooves and localized periodontitis.

A total of 404 maxillary lateral and central incisors were examined in a group of 101 individuals comprising 64 males and 37 females for the presence of palato-radicular groove (PRG). The methods used to document the presence of PRG situated at or apical to the cemento-enamel junction (CEJ) included clinical probing, flap operation and inspection with the aid of an enlarging oral mirror. PRGs were classified by location in the mesial, distal and midpalatal areas of affected teeth. The plaque index (P1I), gingival index (GI) and probing pocket depth (PPD) were recorded on the lingual aspect of the teeth examined. Those PRG with initial PPDs of > or = 4 mm and located at or apical to the CEJ were counted as PRG with PPD. The difference in the PRG location for teeth with and without PPDs was analyzed via the chi 2 test. The relationship between the presence of a PRG and the patients periodontal health and plaque accumulation were analyzed using the t-test. (ABSTRACT TRUNCATED AT 250 WORDS)
Quantitative data on the size of synaptic end‐bulbs in the cat's spinal cord. With a note on the preparation of cell models

In 1932 Hoff described a precise method of locating the termination of fiber tracts of the central nervous system. The method depends on identification of degenerative changes in synaptic end-bulbs (boutons terminaux) which have been separated from their cell bodies by surgical means. Further details of the degenerative process have been supplied by Gibson ( '37). The method of bouton degeneration has contributed to the solution of neuroanatomical problems in the hands of a number of investigators, including Hoff ( '32a, b ; '35), Hoff and Hoff ( '34), Foerster, et al. ( '33) ; Szentiigothai (Schimert, '38, '39a, b ; Szentbgothai-Schimert, '41 ; Szentbgothai, '42) Glees ('41, '42, '44) ; Glees and Le Gros Clark ('41) ; Glees, et al. ( '46) and Brodal ( '49). I n spite of the reports mentioned above, the method of end-bulb degeneration has not enjoyed the popularity it deserves. Two objections appear to have retarded its more widespread use. First, several authors (e.g., Barnard, '40) have written in cautionar9 terms because of the vagaries of silver technrcs. However, Cajal's reduced silver nitrate method, following formalin fixation, consistently
Thrombolytic Use in Acute Ischemic Stroke Patients with Concurrent Infective Endocarditis : Emphasis on History , Physical Exam , Outcomes , and Review of Literature

Background: Intravenous (IV) alteplase is not recommended in acute ischemic stroke patients with concurrent infective endocarditis (AIS-IE) due to high rates of hemorrhagic conversion, death, and disability. Methods: We report a case in which a patient received IV alteplase and was later diagnosed with possible infective endocarditis. Previously published literature regarding similar cases and articles on PubMed was also reviewed. Case summary: A 36-year-old male patient with no history of hypertension, diabetes, a trial fibrillation, hyper lipidemia, or other classic risk factors for stroke presented to the emergency room (ER) with a sudden onset of left hemiparesis, numbness, and left facial droop. NIHSS at admission was 10. His blood pressure was 137/100 mmHg, temperature 98.1 F, respiratory rate 23, and pulse 105. His WBC count was 13.8 K/UL. Physical exam was negative for cardiac murmurs, fever, and vascular stigmata associated with IE. Patient had a history of migraine headaches, but denied headache at the time of presentation. Per the patient’s history, he had suffered a low-grade fever for the past few days which he had attributed to West Nile fever. Patient’s history was negative for seizures and stroke. Initial computed tomography (CT) of the head was negative for any bleeding. Patient was assessed and administered IV alteplase (0.9mg/kg) within the American Heart Association’s (AHA) time frame recommendations (67 minutes from onset of symptoms). The next day the patient’s hemiparesis resolved with NIHSS of 0. Considering his reported history of low-grade fevers in conjunction with multiple small infarcts revealed on his MRI, infective endocarditis (IE) was investigated as a possible cause of the embolic stroke. Blood cultures were positive for gram positive cocci in clusters. Follow-up imaging revealed asymptomatic hemorrhagic conversion. IV Penicillin G was initiated and prescribed for six weeks. Conclusion: While evaluating young AIS patients for IV alteplase, who present without classic stroke risk factors, a thorough history and clinical exam with a specific focus on the signs and symptoms of IE, systemic inflammatory response syndrome (SIRS), and other embolic diseases can help reduce hemorrhagic complications. Absence of fever, vascular stigmata, and cardiac murmur at presentation does not necessarily exclude the possibility of IE. Afebrile patients who report a recent history of fever warrant caution before treatment with thrombolytics.
Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps

The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.
Unexpected brain atrophy following administration of intratumoral interferon alpha-2b for cystic craniopharyngioma: A case report

Introduction: the use of intracystic treatments is relatively new in the treatment of craniopharyngioma and has the potential for decreased morbidity and long-term control in patients with recurrent cysts after radiotherapy as well as delaying radiotherapy treatment in young children. We describe a case in which the therapeutic use of interferon alpha-2b (IFNa-2b) was associated with an adverse effect that has not yet been documented in the medical literature. case report: An eight-year-old boy with a history of a craniopharyngioma was presented with radiological evidence of recurrence. He was first diagnosed at the age of eight months and had undergone repeated subtotal resections. At the age of three, he also received adjuvant radiotherapy after one of these resections. On this presentation of recurrence, a decision was made to offer him intracystic treatment with IFNa-2b. Although the typical pre-treatment leakage test was positive, the planned treatment decision was maintained following extensive multi-disciplinary consult with both local and international teams who advised that any
Psychological Contract Imbalance and Management of Enterprise Research and Development Personnel

This paper begins with the definitions of psychological contract imbalance and EVLN behaviors. Then, a theory is proposed to further study the influencing model of EVLN behaviors of psychological contract imbalance on enterprise Research and Development (R&D) personnel. A demonstrative research has been done through questionnaires with the researchers in one of the aircraft design institutes in China. Based on previous studies, statistics analysis has been accomplished with the analysis methods of factor, correlation, path, and regression. Therefore, on the basis of validated hypothesis, the conception and countermeasure are proposed for the psychological contract imbalance and management of enterprise R&D personnel.
Neuroactive steroids regulate astroglia morphology in hippocampal cultures from adult rats

Recent evidence indicates that astroglia may be involved in the synthesis of endogenous neurosteroids. The extension of glial fibrillary acidic protein (GFAP)‐immunoreactive astroglial cell processes was assessed in hippocampal slice cultures from adult gonadectomized male rats under the influence of the neurosteroids dehydroepiandrosterone, dehydroepiandrosterone sulfate, dehydroepiandrosterone estereate, pregnenolone, pregnenolone sulfate, and pregnenolone oleate. The effects of neurosteroids were compared to those induced by the gonadal steroids testosterone, 17ß‐estradiol and progesterone. Astrocytes in hippocampal slice cultures had a morphology that was indistinguishable from that observed in the hippocampus fixed in situ. Castration of adult male rats resulted in a significant decrease in the extension of GFAP‐immunoreactive processes, both in tissues fixed in situ and in slice cultures. In contrast, incubation of slice cultures from gonadectomized animals with pregnenolone, pregnenolone sulfate, 17ß‐estradiol, and testosterone enhanced the extension of GFAP‐immunoreactive processes. While other steroids tested did not affect this parameter, dehydroepiandrosterone and its sulfate and estereate derivatives induced the transformation of astroglial cells into hypertrophic and highly GFAP immunoreactive cells with the morphological characteristics of reactive astroglia. We conclude that neurosteroids regulate the morphology and/or GFAP distribution of astrocytes in hippocampal slice cultures from adult rats. © 1995 Wiley‐Liss, Inc.
The Effect of Labor Market Rigidities on the Labor Force Behavior of Older Workers

Most older workers retire completely from full-time work with no intervening spell of part-time work. This is incompatible with a model of retirement in which tastes for work gradually shift with age toward leisure and hours may be freely chosen. A survey of institutional arrangements such as pensions and Social Security and of normal business practices resulting from fixed costs of employment and team production leads to the conclusion that most workers face rather limited choices consisting of a high-paying year-round job and low-paying part-time work. Therefore, someone approaching retirement who wants to retire gradually from a career type job will have to change jobs, losing job-related skills, and to compete for low-paying, easy entry jobs. Faced with that option most retire completely.
Design and analysis of a hybrid control scheme for sandwich nonsmooth nonlinear systems

This paper addresses an open control problem: the control of sandwich non-smooth nonlinear systems. Of interest are sandwiched non-smooth nonlinearities between linear dynamic blocks, as illustrated by a hydraulic valve system with a sandwiched dead-zone. A hybrid control scheme for the control of such sandwich systems is developed and presented in detail. The proposed control scheme employs an inner-loop discrete-time feedback design and an outer-loop continuous-time feedback design, combined with a nonlinearity inverse, to cancel the nonlinearity effect, for improving output tracking. The stability and tracking performance of the closed-loop control system are analyzed. Simulations are used to illustrate the effectiveness of the proposed hybrid control design.