Miracle-dz/UniFAR-FTUs huggingface dataset:
“Showrooming” in Consumer Electronics Retailing: An Empirical Study

ABSTRACT The present study focuses on multichannel retailing strategies and describes the state of consumer behavior regarding “showrooming” (the practice of examining merchandise or products in a retail store and then buying it online). Founded on the theory of planned behavior (TPB), the authors examine the antecedents of showrooming using data collected from a sample of 176 retail consumers. Based on their results, they define perceived control, website compatibility, and subjective norms as the main antecedents of consumer attitudes toward online purchases. Additionally, they state that previous experience and reasons against purchasing online are directly associated with consumers’ intention to purchase on the retailer’s website. Finally, some theoretical conclusions and practical implications for retailers are discussed.
Whose Choice Is It? Shared Decision Making in Nephrology Care

Patients living with end‐stage renal disease (ESRD) are faced with numerous decisions across the trajectory of their illness. Shared decision making (SDM) offers a patient‐centered approach to engage patients in decision making in meaningful ways. Using an SDM approach, patients and providers collaborate to make healthcare decisions by taking into account the best available empirical evidence, in conjunction with the patient’s values, preferences, and individual circumstances. In this article, we outline the principles of SDM; highlight the broad range and context of decisions faced by patients living with ESRD; review decision‐support interventions; and consider opportunities and challenges for implementing SDM into usual ESRD practice. A summary of current knowledge and areas for research and further investigation concludes the paper. Because nephrology team members spend a lot of time interacting with patients during treatments and follow‐up care, they are well positioned to engage in SDM. Healthcare systems need innovation in communication to ensure the ethical application of important technological improvements in renal treatments, and to ensure that patient decision‐support processes are available. SDM is a promising innovation to support the recalibration of care for patients living with end‐stage renal disease.
Monitoring wound healing of burn in rat model using human Wharton’s jelly mesenchymal stem cells containing cGFP integrated by lentiviral vectors

Objective(s): Human Wharton’s Jelly mesenchymal stem cells (hWMSCs) are undifferentiated cells commonly used in regenerative medicine. The aim of this study was to develop a reliable tool for tracking hWMSCs when utilized as therapeutics in burnt disorders and also to optimize the cell-based treatment procedure. Materials and Methods: The hWMSCs were first isolated from fresh umbilical cord Wharton’s jelly and cultured. The 293LTV cell line was transfected by cGFP containing lentiviral vector and the helper plasmids for production of the viral particle. The viral particles were collected to transduce the hWMSCs. The transduced cells were finally selected based on resistance to puromycin. The burned rats (n=24) were treated with cGFP expressing hWMSCs using the cell spray method, with the cells being tracked 7, 14 and 21 days later. The rats were sacrificed 7, 14 and 21 days following treatment and paraffin embedded sections prepared from the burned area for downstream pathological analyses. Results: The lentiviral particles carrying the cGFP gene were generated and the hWMSCs were transduced. The cGFP-expressing hWMSCs were detected in the burned tissue and the burned injuries were improved dramatically as compared to control. Conclusion: Because of the establishment of stably transduced cGFP expressing cells and the ability to detect cGFP for a relatively long-time interval, the method was found to be quite efficient for the purpose of cell tracking. The combination of hWMSC-based cell therapy and sterile Gauze Vaseline (GV) as covering was proven much more efficient than the traditional methods based on GV alone.
Improving uptake and adherence in cardiac rehabilitation: literature review.

AIMS This paper presents a comprehensive systematic review of literature carried out to identify studies of interventions to improve uptake, adherence and professional compliance in cardiac rehabilitation. BACKGROUND Guidelines recommend that cardiac rehabilitation should be offered to patients following acute myocardial infarction and revascularization. Uptake and adherence are low, particularly in women, older people, and socially deprived and ethnic minority patients. Although patient, service and professional barriers to rehabilitation uptake have been described, no attempt has been made to evaluate systematically interventions aimed at improving uptake and adherence in cardiac rehabilitation. METHODS A comprehensive search strategy identified studies of cardiac rehabilitation, using the terms uptake, adherence and compliance. The search included grey literature, hand searching of specialist journals and conference abstracts. No language restriction was applied. Studies were summarized in three qualitative overviews and assessed by quality of evidence. RESULTS From 3261 publications identified, 957 were acquired on the basis of title or abstract. Few studies were of sufficient quality to make specific recommendations. Six, 12 and five studies, respectively, provided adequate information on methods to improve uptake, adherence or professional compliance. A minority of studies were randomized controlled trials. Studies of motivational and self-management strategies and use of lay volunteers showed some promise in improving rehabilitation uptake or lifestyle change. Nurse-led coordination of care after hospital discharge may have a role in improving rehabilitation uptake. Limited information was provided on resource implications, and there was a lack of studies with under-represented groups. The literature contained numerous suggested interventions which merit evaluation in appropriately designed studies. CONCLUSIONS Little research has been reported evaluating interventions to improve uptake, adherence and professional compliance in cardiac rehabilitation. A wide range of possible interventions was identified and further evaluations of methods are indicated.
TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides*

Bacterial cell walls contain lipoproteins/peptides, which are strong modulators of the innate immune system. Triacylated lipopeptides are assumed to be recognized by TLR2/TLR1-, whereas diacylated lipopeptides use TLR2/TLR6 heteromers for signaling. Following our initial discovery of TLR6-independent diacylated lipopeptides, we could now characterize di- and triacylated lipopeptides (e.g. Pam2C-SK4, Pam3C-GNNDESNISFKEK), which have stimulatory activity in TLR1- and in TLR6-deficient mice. Furthermore, for the first time, we present triacylated lipopeptides with short length ester-bound fatty acids (like PamOct2C-SSNASK4), which induce no response in TLR1-deficient cells. No differences in the phosphorylation of MAP kinases by lipopeptide analogs having different TLR2-coreceptor usage were observed. Blocking experiments indicated that different TLR2 heteromers recognize their specific lipopeptide ligands independently from each other. In summary, a triacylation pattern is necessary but not sufficient to render a lipopeptide TLR1-dependent, and a diacylation pattern is necessary but not sufficient to render a lipopeptide TLR6-dependent. Contrary to the current model, distinct lipopeptides are recognized by TLR2 in a TLR1- and TLR6-independent manner.
Two-Mode Coexistence in 1550-nm VCSELs With Optical Feedback

Two-mode coexistence in 1550-nm vertical-cavity surface-emitting lasers with optical feedback is experimentally investigated in detail. With the increase of the feedback strength, the two-mode coexistence region is enlarged for continually varied current. The feedback delay time has little influence on the two-mode coexistence region distribution under our experimental conditions. Moreover, a mapping of polarization-mode suppression ratio between two linear polarization (LP) modes is presented in the parameter space of the bias current and the feedback strength. In addition, the simultaneous chaos outputs of two LP modes are obtained for a certain two-mode coexistence region.
Communication gaps and readmissions to hospital for patients aged 75 years and older: observational study

Objectives: (1) To identify communication gaps at hospital discharge for older people who are readmitted within 28 days; (2) to assess the contribution of incomplete discharge information to readmission; (3) to identify measures that might improve communication at hospital discharge. Design: Retrospective case-note review. Setting: A teaching hospital in Nottingham, UK. Sample: 108 consecutive patients aged 75 and over who were readmitted as an emergency within 28 days of previous discharge Main outcome measures: (1) Proportion of patients discharged with insufficient arrangements and/or information for immediate safe continuity of care; (2) proportion of patients with medication management information missing; (3) proportion of readmissions related to incomplete medication management information and proportion of patients for whom this was preventable. Results: Thirty patients (28%) returned within 3 days of discharge, 48 (44%) within 7 days and the remainder within 28 days. Sixty-seven (62%) patients either had no discharge letter or returned before the letter was typed. Documentation of changes in medication was incomplete on two-thirds of all discharge documents. Readmission was considered to be related to medication for 41 (38%) patients and to be preventable for 25 (61%) of these. There were preventable discharge communication gaps, including monitoring information, for 22 (54%) of these patients. Conclusion: Incomplete documentation at discharge was common, particularly for medication management. It is likely that communication gaps contributed to many of the preventable adverse events and readmissions.
[Predicting factors of eating disorders and general psychological symptoms in female college students].

OBJECTIVE To compare and determine the relative effects of six of the variables (family functioning, self-esteem, obsessive-compulsive symptoms, depressive symptoms, locus of control and Body Mass Index-BMI) related to the etiology of eating disorders in predicting eating disorder symptoms and the general symptom index. METHOD Two hundred and ninety-two female college students completed the Rosenberg Self-Esteem Scale (RSES), the Family Assessment Device (FAD), the Eating Attitude Test (EAT), the Symptom Check List (SCL-90-R), Rotter's Internal-External Locus of Control Scale (RIELCS), and the Beck Depression Inventory (BDI). Multiple regression analysis was employed, and scores of the obsessive-compulsive subscale of SCL-90-R, BMI, RSES, FAD, BDI and RIELCS were used as predictors of EAT total scores. The second multiple regression analysis was employed with the same independent variables as predictors of the General Symptom Index (GSI) of SCL-90-R. RESULTS Obsessive-compulsive symptoms were the best predictor of the total score of EAT, and the second was the BMI scores. Depressive symptoms and self-esteem scores were significantly correlated with EAT scores but these variables were not chosen for inclusion in the regression equation. There was a strong relation between scores on BMI and scores on EAT. BMI scores were correlated nonsignificantly with the scores of the other variables. RIELCS and FAD scores were not significantly correlated with EAT scores. Obsessive-compulsive symptoms were also the best predictor of GSI of SCL-90-R and the second best predictor was the RSES. FAD was significantly correlated with SCL-90-R GSI scores, depression and obsessive compulsive scores. CONCLUSION It appears that obsessive-compulsive symptoms were the best predictor of pathologic eating behavior. BMI was the second predictor of EAT scores. Locus of control and family functioning were not correlated with eating pathology. Family functioning scores were significantly correlated with the GSI scores, and depressive and obsessive-compulsive symptoms. Obsessive-compulsive symptoms were also the best predictor of the GSI scores.
What Stress Does to Your Brain: A Review of Neuroimaging Studies

Objective: Recent neuroimaging studies aimed at investigating effects of psychological stress on the neural activity have used a range of experimental paradigms to elicit an acute stress response. The goal of this review is to, first, summarize results from these studies from a perspective of task design and, second, assess the appropriateness of the different stress tasks used. Method: We completed a PubMed search on recent articles that have examined the effects of psychological stress on neural processes in a neuroimaging environment. Selected articles were arranged according to the stress task used in the following categories: script-driven stress stimuli, Stroop colour-word interference task, speech in front of an audience, serial subtraction, and Montreal Imaging Stress Task (MIST). Results: Only studies using serial subtraction or the MIST were able to induce a significant cortisol stress response in their participants. Most consistent findings include decreased activity in orbitofrontal regions in response to stress. Additional findings of note are increases in activity in the frontal lobes, particularly the anterior cingulate cortex, as well as deactivation of the limbic system, particularly the hippocampus. Conclusion: Research to date is beginning to outline the involvement of prefrontal and limbic regions in perception and modulation of psychological stress. However, additional research is needed in designing a neuroimaging stress task that will yield a significant cortisol stress response consistently, across populations and laboratories.
Humanitarian Coordination in Haïti: The Role of Clusters in the Outsourcing of Aid

The earthquake of 12 January 2010 in Haiti has highlighted the challenges of a humanitarian response of this scale in a country that is already weakened by successive crises. This article analyzes the coordination mechanism put in place by the Office for the Coordination of Humanitarian Affairs (OCHA) of the UN, to support the Haitian authorities. The study of the dynamics of inclusion and exclusion will demonstrate the obstacles to the integration of local actors in the coordination, and so planning, of humanitarian aid.
Local brain connectivity across development in autism spectrum disorder: A cross‐sectional investigation

There is a general consensus that autism spectrum disorder (ASD) is accompanied by alterations in brain connectivity. Much of the neuroimaging work has focused on assessing long‐range connectivity disruptions in ASD. However, evidence from both animal models and postmortem examination of the human brain suggests that local connections may also be disrupted in individuals with the disorder. Here, we investigated how regional homogeneity (ReHo), a measure of similarity of a voxel's timeseries to its nearest neighbors, varies across age in individuals with ASD and typically developing (TD) individuals using a cross‐sectional design. Resting‐state fMRI data obtained from a publicly available database were analyzed to determine group differences in ReHo between three age cohorts: children, adolescents, and adults. In typical development, ReHo across the entire brain was higher in children than in adolescents and adults. In contrast, children with ASD exhibited marginally lower ReHo than TD children, while adolescents and adults with ASD exhibited similar levels of local connectivity as age‐matched neurotypical individuals. During all developmental stages, individuals with ASD exhibited lower local connectivity in sensory processing brain regions and higher local connectivity in complex information processing regions. Further, higher local connectivity in ASD corresponded to more severe ASD symptomatology. These results demonstrate that local connectivity is disrupted in ASD across development, with the most pronounced differences occurring in childhood. Developmental changes in ReHo do not mirror findings from fMRI studies of long‐range connectivity in ASD, pointing to a need for more nuanced accounts of brain connectivity alterations in the disorder. Autism Res 2015. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.
HYPERTENSION IN HEMODIALYSIS PATIENTS: Hypertension and Survival in Hemodialysis Patients

Hypertension is clearly an independent risk factor for cardiovascular (CV) events and death in the general population, but the relationship between blood pressure (BP) and survival in dialysis patients is less clear. In dialysis populations at lower risk of CV events, BP is directly related to survival, while in those with high risk, it has been difficult to show such an effect. The effects of cardiac disease complicate the relationship between BP and outcome. Retrospective studies of large cohorts, with high prevalence of CV disease, have shown a U‐shaped relationship between both systolic and diastolic BP and outcome. These findings probably reflect a high prevalence of cardiac failure and thus high mortality associated with low BP (i.e., a so‐called reverse causation). Pulse pressure (high systolic BP and low diastolic BP) predicts outcome in hypertensive dialysis patients. Whether this reflects advanced vessel wall disease or is an independent etiologically significant risk factor is unclear. However, the current uncertainties as to the exact relationship between BP and outcome in dialysis patients do not warrant complacency regarding the prevention and treatment of hypertension.
Consideration of Agricultural Education as a Career: A Statewide Examination by High School Class Year of Predicting Factors.

The shortage of teachers in Illinois is reflective of a recent trend where agricultural education graduates of in-state post-secondary institutions have not met the need for the number of available teaching positions. The retirement of the many teachers from the Baby Boomer generation is looming over the profession, making recruitment efforts essential (Illinois Board of Education Report, 2014). With secure funding sources of higher education dwindling, efficiency and effectiveness of recruitment efforts are critical if agricultural education is to continue to survive and thrive by facilitating a steady stream of highly qualified teacher candidates into the field. The purpose of this study was to examine factors influencing high school student consideration of agricultural education as a future career. We included students in grades 9 through 12 (n = 817) from 56 different agricultural education programs. Within the overall sample, parental support and a student’s report of their agriculture teacher emerged as the most powerful predictors, while noteworthy differences arose across class years. These findings possess significant implications for the timing and focus of recruitment efforts.
Citations and references as keys to relevance ranking in interactive IR

According to the principle of Polyrepresentation (Ingwersen & Jäärvelin, 2005; Ingwersen, 2012) bibliographic references in scientific documents as well as citations to documents have the potential of serving as useful features for re-ranking of retrieved documents. References (and thus citations) can be seen as footprints of information interaction, because of the behavioral conventions built in to the scientific communication and publication process. They are manifestations of degrees of utility of methods, results and ideas made earlier on by other scientists. The use of references in IR has been demonstrated to improve retrieval performance (Skov et al. 2008), whereas the number of citations has not provided similar improvements.
Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases‐3 (TIMP‐3)‐encoding gene

A complex interplay between enzymes involved in extracellular matrix formation and their inhibitors is thought to control organogenesis during mammalian development. Disturbance of this balance may result in a wide range of diseases, including macular degeneration, arthritis, and tumor metastases. In order to define elements which may be involved in regulating human tissue inhibitor of metalloproteinase 3 (TIMP3) expression, we isolated and sequenced a clone containing 1315 bp of the 5′‐upstream region of the human TIMP‐3‐encoding gene. A 1.2 kb fragment of this clone, which contains multiple motifs which are binding sites for known transcription factors, was used to drive expression of the lacZ reporter gene in multiple lines of transgenic mice. TIMP3 promoter activity, detected through β‐galactosidase histochemical assay, was observed at high levels in selected tissues, the identity of which varied according to developmental stage. TIMP3 promoter activity was detected at embryonic and early postnatal stages in tissues undergoing extensive remodeling, such as developing somites, bones and joints, choroid plexus, webs between the digits, and the spongiotrophoblastic portion of the placenta. In adulthood, TIMP3 promoter activity was restricted to a few tissues which exhibit high metabolic activity or rapid turnover. These include the retinal pigment epithelium (RPE), cells of the kidney cortex, hair follicles, gingiva, ovarian follicles, and testis. The results suggest that TIMP3 expression plays an active role in developmental patterning and in the maintenance of specific differentiated tissues. Dev. Dyn. 1998;211:228‐237. © 1998 Wiley‐Liss, Inc.
Evaluation of 89 Compounds for Identification of Substrates for Cynomolgus Monkey CYP2C76, a New Bupropion/Nifedipine Oxidase

Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to humans, including their cytochrome P450s (P450s). Most cynomolgus monkey P450s are almost identical (≥90%) to human P450s; however, CYP2C76 has low sequence identity (approximately 80%) to any human CYP2Cs. Although CYP2C76 has no ortholog in humans and is partly responsible for species differences in drug metabolism between cynomolgus monkeys and humans, a broad evaluation of potential substrates for CYP2C76 has not yet been conducted. In this study, a screening of 89 marketed compounds, including human CYP2C and non-CYP2C substrates or inhibitors, was conducted to find potential CYP2C76 substrates. Among the compounds screened, 19 chemicals were identified as substrates for CYP2C76, including substrates for human CYP1A2 (7-ethoxyresorufin), CYP2B6 (bupropion), CYP2D6 (dextromethorphan), and CYP3A4/5 (dextromethorphan and nifedipine), and inhibitors for CYP2B6 (sertraline, clopidogrel, and ticlopidine), CYP2C8 (quercetin), CYP2C19 (ticlopidine and nootkatone), and CYP3A4/5 (troleandomycin). CYP2C76 metabolized a wide variety of the compounds with diverse structures. Among them, bupropion and nifedipine showed high selectivity to CYP2C76. As for nifedipine, CYP2C76 formed methylhydroxylated nifedipine, which was not produced by monkey CYP2C9, CYP2C19, or CYP3A4, as identified by mass spectrometry and estimated by a molecular docking simulation. This unique oxidative metabolite formation of nifedipine could be one of the selective marker reactions of CYP2C76 among the major CYP2Cs and CYP3As tested. These results suggest that monkey CYP2C76 contributes to bupropion hydroxylation and formation of different nifedipine oxidative metabolites as a result of its relatively large substrate cavity.