Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of the Antioxidant Activity of 31 Amazonian Vegetable Species of Tamshiyacu Loreto-Peru

The aim of this study was evaluate the antioxidant capacity of the extracts of the leaves of 31 vegetable species collected at the vicinity of the town of Tamshiyacu, in the department of Loreto, Peru. The percentage of inhibition of free radicals of 2,2-diphenyl-1-picrylhydrazyl (DPPH) was calculated. From the concentration of the best species with high activity, which were three, it was realized the analysis of total concentration of phenolic compounds and alkaloids was analyzed by UV/Vis spectrophotometry. Besides the metanolics extracts were submitted to fractionation in chromatographic column and the fractions with similar molecules, grouped by thin layer chromatography. The final fractions were analyzed by a Gas Chromatograph coupled to mass spectrometry (CG-MS), to identify the molecules present in them and causing this activity. According to the results, the species that showed the best activity at concentrations lower than 5.0 mg/ml were Virola sebifera, Caryocar glabrum and Tapirira guianensis. The concentration of total phenolic compounds was 18580.9, 15180.7 and 11568.7 mg/100g for V. sebifra, C. glabrum and T. guiannensis, and total alkaloids were 36.6, 0.0 and 74.0 mg/100g for these same species. The main secondary metabolites are 3,5-di-tert-butyl-4-hydroxyanisole and normolatedol and caryophyllene, in V. sebifera, diisooctyl dicarboxylate.1,2-benzene and 3, 5-bis (1,1-dimetyl etill-phenol in C. glabrum and diisoctylphthalate, α-panasinseno, and vitamin E in T. guianensis.
Study on the hormonal profile in crossbred dairy cows in relation to repeat breeding at Baghabari milk shed areas, Bangladesh

Repeat breeding (RP) is a one of the most significant problem in dairy cattle because it increased production cost of insemination, treatment, feed, labor and management and also increased calving interval with decreased milk production. This study was conducted at the different Bathan areas of Shahjadpur Upazila under Sirajgonj district. The total of 30 repeat breeder cows was selected randomly to determine their reproductive hormonal profile before and after synchronization at the selected areas and repeat breeder cows were marked by ear tag and collected breeding history of each individual cow. All experimental RP were synchronized by the administration of GnRH (day- 0), PGF2α (day-7) and Artificial Insemination (AI) with GnRH (day-9). Blood samples were collected before and after synchronization during standing heat period of estrous cycle of each cow. The total experiment was done and analyzed in the laboratory by using endocrine detection kits (Mono LelacR USA). This present study revealed that the level of luteinizing hormone (LH), follicle stimulating hormone (FSH), progesterone (P4) were significantly differed between repeat breeder cows and synchronized repeat breeder cows. These findings clearly indicated that reproductive hormonal aberrations might be one of the major causes of repeat breeding in Baghabari milk shed areas. Asian Australas. J. Biosci. Biotechnol. 2018, 3 (3), 237-240
A systematic review of literature to evaluate the burden of physical and psychological symptoms and palliative care in patients diagnosed with idiopathic pulmonary fibrosis

Background Palliative care improves quality of life in patients with life-threatening illnesses, such as idiopathic pulmonary fibrosis (IPF), in a holistic manner and should be integrated early into the management of these patients. Objective To evaluate the degree of physical and psychological symptoms in patients with IPF and the extent to which palliative care is used in patient management. Methods Several databases were searched for studies reporting on symptom burden, quality of life or palliative interventions in patients with IPF. Results A total of 46 articles were included in this review. Studies showed that many patients experienced dyspnoea, which improved with pulmonary rehabilitation in some cases. Fatigue and poor quality of sleep had a notable negative impact on daily life activities. Instruments evaluating anxiety and depression showed that many patients with IPF experienced mild to moderate depression and anxiety. Quality of life was shown to be negatively affected across all domains. Two studies indicated poor referral to palliative care units and one study reported positively on the use of morphine for managing breathlessness in advanced IPF. Conclusion Patients with IPF generally experience poor quality of life. Patients are seldom referred to palliative care, even in developed countries. No data were available on the use of palliative care in developing countries. Furthermore, research on the burden of symptoms and management of these symptoms appears to be limited. Increased awareness of and research on the palliative care needs of patients with IPF are recommended, particularly in resource-limited settings such as South Africa.
Phase II COLET study: Atezolizumab (A) + cobimetinib (C) + paclitaxel (P)/nab-paclitaxel (nP) as first-line (1L) treatment (tx) for patients (pts) with locally advanced or metastatic triple-negative breast cancer (mTNBC).

1013 Background: COLET showed that the addition of C (MEK1/2 inhibitor) to P resulted in an increased ORR (38%; Brufsky, SABCS 2017); IMpassion130 demonstrated clinical benefit with the combination of PD-L1 inhibitor A and nP as 1L tx for pts with mTNBC (Schmid, N Engl J Med, 2018). We investigated the efficacy and safety of A + C + P/nP in pts with mTNBC, as this combination may target multiple cancer immune escape mechanisms simultaneously. Methods: In the multi-stage, multi-cohort Phase II COLET study, pts with histologically confirmed mTNBC were randomized 1:1 to receive 1L tx with A 840 mg IV (d1, d15) + C 60 mg qd (d3-d23) + P 80 mg/m2 IV (d1, d8, d15; cohort 2) or + nP 100 mg/m2 (d1, d8, d15; cohort 3) in 28-day cycles until progression or toxicity. The primary endpoint (EP) was confirmed ORR per investigator-assessed RECIST 1.1. Additional EPs were DOR, PFS, OS, safety and exploratory efficacy by PD-L1 status. Results: As of 10 Aug 2018 (6.5-mo median follow-up), 63 and 62 pts were evaluable for efficacy and safety, respectively. In cohorts 2 and 3, 21 pts (66%) and 20 pts (65%) had received neo/adjuvant taxane tx, 9 pts (28%) and 6 pts (19%) had a disease-free interval of ≤12 mo, respectively. All pts had ≥1 AE; 69% and 70% had Gr 3-5 AEs and 47% and 43% had serious AEs in cohorts 2 and 3, respectively. Efficacy data for all pts and by PD-L1 expression on tumor-infiltrating immune cells (IC ≥1%; PD-L1+) are summarized in the Table. Conclusions: ORRs were similar between the A + C + P arm and A + C + nP arm. Numerically higher ORR and PFS were observed in pts with PD-L1+ disease. The combination’s safety profile was consistent with the known individual safety profiles, and A did not increase toxicity. Clinical trial information: NCT02322814. [Table: see text]
A clinicopathological study of stomach carcinoma in a tertiary care hospital of central India

Background: The incidence of gastric cancer varies in different part of world. It is a series problem as it involves development of malignancy in stomach and affected by with daily life style of the habituates.Methods: The present study was carried out at tertiary care center of districts of Vidarbha region of Maharashtra and neighborhood districts of Andhra Pradesh and Madhya Pradesh for the tenure of six years. Study and collection of data were assessed by examination of one hundred and seven patients suffering with the gastric carcinoma.Results: Males were found to be more susceptible in a ratio of 1.22/1. Mean age of incidence was assessed as nearly 55 years. Smoking, alcohol, mixed diet, weight gain, positive family history and history acid peptic disease were reported in 23.4%, 24.3%, 63.8%, 2.8% 36.4% and 36.4% cases. Mild to severe anemia was also reported. Most accountable symptom was abdominal pain, followed by vomiting. Lump in abdomen and nausea were some other symptoms. Jaundice in little percentage was also observed. Antrum was most common site of malignancy observed in more than 50% cases. Cardia, pylorus and fundus were involved in 17, 14 and 03 patients. Thickening of stomach wall were observed. Adrenocarcinoma was in 100 patient’s symptoms.Conclusions: Incidence of cases in these areas refers to poor dietary habits. Increasing the literacy and awareness regarding the causative factors in the respective areas contributes to decrease the incidence and risk too.
Contrast-enhanced MR cholangiography (MRCP) with GD-EOB-DTPA in evaluating biliary complications after surgery Colangio-RM con mezzo di contrasto (Gd-EOB-DTPA) nella valutazione delle complicanze biliari post-chirurgiche

Purpose. We assessed the usefulness of contrast-enhanced magnetic resonance cholangiography (CE-MRC) with liver-specific contrast agent in evaluating the biliary tree after hepatic surgery. Materials and methods. A total of 142 patients with suspected biliary complications after liver surgery underwent hepatobiliary MR before and after administration of gadolinium ethoxy benzylic diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Unenhanced MR cholangiopancreatography (MRCP) and postcontrast MRC were obtained in all patients. Blinded image evaluation and semiquantitative analysis comparing MRCP and CE-MRC were performed by two experienced radiologists. Results. In all cases, optimal postcontrast visualisation of the biliary tract was obtained. In 22 patients, a postsurgical biliary complication was confirmed. MRCP detected 64% of lesions, but in 36% of cases, an alteration was only suspected but not clearly defined. CE-MRC allowed definite diagnosis in 100% of cases. Conclusions. Hepatobiliary-specific contrast agents allow for accurate and extensive study of biliary tract alterations, especially in assessing postsurgical complications.
Trastorno Bipolar. Consideraciones clínicas y epidemiológicas

Bipolar disorder is a chronic and recurrent disorder characterized by pathological fluctuations of the mood states. The stages of the disease include hypomanic, maniac and depressive episodes. These episodes interfere in a significant way in the patient´s daily life and his surroundings, with an important repercussion on his health and life quality. For the psychiatrists, the precocious diagnosis of this disease is very important, in order to provide a timely treatment to patients, taking into account the severity of the symptoms and the complications of this disease. Due to this reality, the authors decided to describe the general characteristics of this disorder through a bibliographic review where they exposed the main clinical manifestations, classification, epidemiological aspects, the course of the disease, complications and co-morbidity. The most relevant published works were reviewed to contribute to the process of continued medical education of the health professionals.
Impact of prior chemotherapy or radiation therapy on tumor mutation burden in NSCLC.

2627 Background: Higher non-synonymous tumor mutation burden (TMB) in non-small cell lung cancer (NSCLC) is associated with a higher likelihood of response to checkpoint inhibitors. Tissue samples subject to TMB analysis may be obtained after exposure to cytotoxic chemotherapy or radiation therapy – both of which introduce somatic mutations in DNA and can influence the number of identified mutations. The role of TMB as a potential predictive marker for immunotherapy is evolving, and the impact of prior therapy on TMB could influence interpretation. Methods: Eligible cases were from patients with confirmed NSCLC, available clinical annotation and tumor molecular profiling including TMB analysis at a CLIA-certified genomics laboratory (Caris Life Sciences, Phoenix, AZ) using the Illumina NextSeq platform. TMB was calculated using only missense mutations that had not been previously reported as germline alterations. Treatment history was obtained for each patient under an IRB approved protocol to determine whether patients had had received chemotherapy or radiation therapy in the year prior to collection of the tissue subject to TMB analysis. Data analysis was performed using the chi-square test of deviance to evaluate whether TMB was statistically significantly different between groups, correcting for smoking status. Results: Out of 1,118 patients identified, 459 cases met all eligibility criteria and were evaluated. 76 patients (17%) received either chemotherapy or radiation prior to tissue collection. Samples acquired prior to any therapy had a median TMB of 10 mut/Mb vs. 11 mut/Mb in samples acquired after any therapy. After adjusting for smoking, there was no significant difference in TMB between these cohorts (p = 0.41). Secondary pair wise analysis showed no statistically significant difference in TMB from chemotherapy-naïve and chemotherapy-treated samples (p = 0.28). The same was true for radiation (p = 0.75). Collection of clinical data is ongoing and further analysis, including additional cases will be presented. Conclusions: Though cytotoxic chemotherapy and radiation therapy can introduce somatic mutations, prior exposure to either was not associated with a significant difference in TMB.
Risk factors for postoperative complications and long-term survival in lung cancer patients older than 80 years.

Concomitantly with worldwide population aging, the incidence of lung cancer has been gradually increasing, especially in octogenarian patients (1,2). Because of the physiology and functional status of octogenarians, choosing the most suitable treatment strategy for them is an issue of particular concern. In 1989, Shirakusa and colleagues reported favorable outcomes in octogenarian lung cancer patients who underwent surgical resection from 1978 to 1987 (3). Since then, numerous studies have investigated lung cancer surgery in octogenarians, seeking to identify criteria that can predict the prognosis of octogenarian patients in terms of long-term outcomes and postoperative complications.
Transport Barrier Triggered by Resonant Three-Wave Processes Between Trapped-Particle-Modes and Zonal Flow

We address the mechanisms underlying low-frequency zonal flow generation in a turbulent system through the parametric decay of collisionless trapped particle modes and its feedback on the stabilization of the system. This model is in connection with the observation of barrier transport in reduced gyrokinetic simulations (A. Ghizzo et al., Euro. Phys. Lett. 119(1), 15003 (2017)). Here the analysis is extended with a detailed description of the resonant mechanism. A key role is also played by an initial polarisation source that allows the emergence of strong initial shear flow. The parametric decay leads to the growth of a zonal flow which differs from the standard zero frequency zonal flow usually triggered by the Reynolds stress in fluid drift-wave turbulence. The resulting zonal flow can oscillate at low frequency close to the ion precession frequency, making it sensitive to strong amplification by resonant kinetic processes. The system becomes then intermittent. These new findings, obtained from numerical experiments based on reduced semi-Lagrangian gyrokinetic simulations, shed light on the underlying physics coming from resonant wave-particle interactions for the formation of transport barriers. Numerical simulations are based on a Hamiltonian reduction technique, including magnetic curvature and interchange turbulence, where both fastest scales (cyclotron and bounce motions) are gyro-averaged.
Obstructive sleep apnea in hypertensive adults

Background: Systemic hypertension is a common condition affecting middle aged and elderly individuals. Studies have shown that about half of the patients who have essential hypertension have OSA and half of the patients having OSA have essential hypertension. Therefore, this study was conducted to study OSA in hypertensive patients (untreated and treated). Material and Methods: Subjects with history of Hypertension (with or without treatment) were included in the study. Sleep questionnaire was administered, anthropometric measurements taken and patients were subjected to whole night polysomnography. Observation and Results : 40% of untreated hypertensives and 38% of treated hypertensives had AHI greater than 5. Further it was found that severity of OSA increased as the Systolic, Diastolic Blood pressure increased. BMI, Male sex and treated-untreated hypertension were associated with sleep apnea.
Short-term Clinical Effect of Acupuncture Therapy for Vascular Dementia

A controlled trial was carried out to observe the clinical effects of eight extra-meridians acupuncture therapy on vascular dementia (VD) with Jin Sanzhen therapy as control. The eight extra-meridians acupuncture therapy is the method by selecting acupoints of the eight extra-meridians and the crossing acupoints of eight meridians according to the Linggui Eight Methods. Seventy-four cases of VD were allocated to two groups. Group 1 (n=39) was treated by eight extra-meridians acupuncture therapy and Group 2 (n=35) with Jin Sanzhen therapy. Quantitative tables of HDS, ADL and MMSE were applied to evaluate the therapeutic effects. Contents of serum superoxide dismutase (SOD), glutathione superoxidase (GSH-Px), lipid peroxide (LPO), nitric oxide (NO), epinephrin (E), noradrenaline (NE) and tryptophan (TRP) were determined. The results showed that the total effective rate was 82.05% and 85.71% in Group 1 and Group 2 respectively (P 0.05 ). It is indicated that both eight extra-meridians acupuncture therapy and Jin Sanzhen therapy can improve intelligence index of VD, and the possible mechanism is related to the regulation of central nervous system function, elimination of SOD and reduction of NE and NO secretion.
An Approach For Time-Aware Domain-Based Analysis Of Users’ Trustworthness In Big Social Data

In Online Social Networks (OSNs) there is a need for better understanding of social trust in order to improve the analysis process and mining credibility of social media data. Given the open environment and fewer restrictions associated with OSNs, the medium allows legitimate users as well as spammers to publish their content. Hence, it is essential to measure users’ credibility in various domains and accordingly define influential users in a particular domain(s). Most of the existing approaches of trustworthiness evaluation of users in OSNs are generic-based approaches. There is a lack of domain-based trustworthiness evaluation mechanisms. In OSNs, discovering users’ influence in a specific domain has been motivated by its significance in a broad range of applications such as personalized recommendation systems and expertise retrieval. The aim of this paper is to present an approach to analysing domain-based user’s trustworthiness in OSNs. We provide a novel distinguishing measurement for users in a set of knowledge domains. Domains are extracted from the user’s content using semantic analysis. In order to obtain the level of trustworthiness, a metric incorporating a number of attributes extracted from content analysis and user analysis is consolidated and formulated by considering temporal factor. We show the accuracy of the proposed algorithm by providing a fine-grained trustworthiness analysis of users and their domains of interest in the OSNs using big data Infrastructure.
Glycated Hemoglobin Level is Significantly Associated with The Severity of Ischemic Stroke in Libyan Non- Diabetic and Diabetic Patients

Stroke is a condition that results in high mortality rate and severe disabilities. Most stroke survivors can do experience improvements in their functional abilities, but the amount, rate, timing, pattern, type, and ultimate outcome of the improvements differ across patients and situation (Wolf CD, et al. 2000). Numerous studies were conducted on the prognostic factors of acute ischemic stroke. Stroke severity and patient age are the main predictors of stroke outcome in acute phase (Adams HP, et al. 1999; Frankle MR, et al. 2000; Muir KW, et al. 1996).
Sensory comparison of low-protein recipes with glycomacropeptide-containing Bettermilk(TM) and liquid non-dairy coffee creamer among adults with phenylketonuria

Phenylketonuria (PKU) results from deficiency of phenylalanine hydroxylase enzyme which is responsible for converting the essential amino acid phenylalanine to the non-essential amino acid tyrosine. PKU is treated with a low-protein diet and medical food/ formula providing supplemental protein without excess phenylalanine. Naturally phenylalanine-free, Glycomacropeptide (GMP) used in PKU medical foods/ formulas contains four essential amino acids and is fortified with methionine, leucine, histidine, tryptophan, and tyrosine to provide a near complete protein. Although sensory research has been conducted on GMP-based foods, sensory evaluation of commonly utilized low-protein recipes substituted with GMP-based formulas is undocumented. Such research is critical to development of appealing means for formula consumption. Study objectives were to compare sensory attributes (taste, aroma, texture, and overall acceptability) and preferences for low-protein cream of tomato soup, lemon pudding, and vanilla ice cream containing either a GMP-based formula or unflavored liquid non-dairy coffee creamer as the primary liquid ingredient and to solicit medical formula/food procurement information among adults with PKU. Data were subjected to paired t-tests with the Bonferroni correction (p< 0.0125) and analysis of variance. Thirty-one adults (80% female, 93% white) completed the study. Significantly higher scores (p<0.01) were reported for aroma, taste, and overall acceptability of the control soup and for all four sensory attributes of the control pudding. Control ice cream was ranked significantly higher (p<0.01) in taste and overall acceptability. No
Prevalence of hepatitis C in patients with chronic kidney disease at a tertiary care hospital in north India: a retrospective analysis

Background: Hepatitis C and chronic kidney disease (CKD) both present an unsolved public health problem Hepatitis C virus (HCV) is easily transmitted in haemodialysis units and by kidney transplantation. HCV leads to increased mortality and morbidity due to cirrhosis and hepatocellular carcinoma, while accelerating the progression of CKD. The aim of the study was to describe the demographic, clinical/biochemical profile and prevalence of patients with CKD who have HCV infection.Methods: This was a retrospective analysis of patients with CKD who presented to out/in patient department of medicine in a tertiary care center in Jammu from a period of Feb 2016 to Nov 2018. Detailed clinical history along with previous lab reports were noted and tests for HCV infection were conducted in all patients. Diagnosis of HCV was made via HCV RNA(RT PCR) and positive Anti HCV IgG serology.Results: Total 67 patients were included with median age of 54 years (range 43-72 years) with majority 76.1% being males, and 71.6% within 41-60 years age group. 31.4% were HCV positive out of which 81% were males. 7 patients were found to have co-infection with HIV and HBsAg. Genotype 1 (72%) was found to be more common than Genotype 3. Ultrasonography and Upper GI endoscopy showcased 57% with dilated spleenoportal axis and oesophageal varices respectively.Conclusions: Prevalence of HCV infection in CKD patients is high with genotype 1 being commonest. False negative Anti HCV antibody is common hence screening with HCV RNA is recommended. Strict universal precautions should be employed in hospitals and dialysis units to prevent transmission.