Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyperhomocysteinemia and Low Folate and Vitamin B12 Are Associated with Vascular Dysfunction and Impaired Nitric Oxide Sensitivity in Morbidly Obese Patients

There is a high prevalence of hyperhomocysteinemia that has been linked to high cardiovascular risk in obese individuals and could be attributed to poor nutritional status of folate and vitamin B12. We sought to examine the association between blood homocysteine (Hcy) folate, and vitamin B12 levels and vascular dysfunction in morbidly obese adults using novel ex vivo flow-induced dilation (FID) measurements of isolated adipose tissue arterioles. Brachial artery flow-mediated dilation (FMD) was also measured. Subcutaneous and visceral adipose tissue biopsies were obtained from morbidly obese individuals and non-obese controls. Resistance arterioles were isolated in which FID, acetylcholine-induced dilation (AChID), and nitric oxide (NO) production were measured in the absence or presence of the NO synthase inhibitor, L-NAME, Hcy, or the superoxide dismutase mimetic, TEMPOL. Our results demonstrated that plasma Hcy concentrations were significantly higher, while folate, vitamin B12, and NO were significantly lower in obese subjects compared to controls. Hcy concentrations correlated positively with BMI, fat %, and insulin levels but not with folate or vitamin B12. Brachial and arteriolar vasodilation were lower in obese subjects, positively correlated with folate and vitamin B12, and inversely correlated with Hcy. Arteriolar NO measurements and sensitivity to L-NAME were lower in obese subjects compared to controls. Finally, Hcy incubation reduced arteriolar FID and NO sensitivity, an effect that was abolished by TEMPOL. In conclusion, these data suggest that high concentrations of plasma Hcy and low concentrations of folate and vitamin B12 could be independent predictors of vascular dysfunction in morbidly obese individuals.
A Novel Inductive Pulsed Power Supply Consisting of a Three-Winding Pulse Transformer With Parallel Switching Scheme

Inductive pulsed power supply (IPPS) is considered as an alternative to capacitive one due to its higher energy density. An opening switch is necessary for an IPPS because it interrupts the charging circuit and transfers the stored energy to the load. A major technical challenge inherent to the IPPS is the overvoltage across the opening switch, i.e., the open-circuit voltage. Moreover, obtaining a larger current, especially with a steeper rising edge, will further increase the open-circuit voltage. A novel IPPS based on a three-winding pulse transformer, consisting of two primary windings and one secondary winding, is presented in this article to improve the output current and reduce the open-circuit voltage. The two primary inductors adopted a parallel switching scheme, namely, series charging and parallel discharging. Its working principle is analyzed first in detail. The theoretical analysis and simulation results have verified the superiority of the novel IPPS in improving the output current and reducing the open-circuit voltage.
Filtering Dielectric Resonator Antenna Using Terminal-Loaded Resonators

A new filtering dielectric resonator (DR) antenna (DRA) is presented in this paper. The DRA and its feedline provide a bandpass response. The antenna feedline consists of two terminal-loaded microstrip resonators (MRs), which gives two independently tuned nulls with an improved selectivity. For the DRA, it is excited in the HEM113 mode, serving not only as a radiator but also as the last-stage resonator of bandpass filter (BPF).
Wideband Fixed- and Scanned-Beam Millimeter Wave Antenna Arrays for 5G Applications

This paper presents the design of millimeter wave (mm-Wave) antenna arrays with beam-scanning capabilities and potential use for fifth generation (5G) applications. We begin with a fixed-beam low-profile antenna array, which has a wide bandwidth and high gain in the millimeter-wave (mm-wave) band, and then go on to add the beam-scanning feature to the array. The proposed antenna covers most of the Ka-band, has a bandwidth of 10 GHz and exhibits a maximum gain of approximately 25 dB for the array dimension investigated, which exhibits good aperture efficiency. Next, the array is modified by using a beam scanning technique, which enables it to carry out a 2D beam scan at a fixed frequency, without using conventional phase shifters that are lossy as well as costly at mm waves. The issue of circular polarization (CP) is also investigated and CP is achieved by adding transverse radiating elements to the aperture array. Illustrative designs of the proposed antennas are included in the paper.
Unauthorized Location Inference Using Smart Device Pressure Sensor

Accessing private user information through smart devices has become an increasing concern recently. Even though smart device operating systems require user permission for perceived sensitive information, side channel attacks using inference can result in serious security breaches. In this work, we present an online learning method that infers location from raw pressure sensor data. The online method mitigates the error arising from changing weather conditions, without the need to obtain any data from weather stations. We demonstrate how a long short-term memory (LSTM) neural network trained by sequences of locations and their corresponding pressure patterns is capable of inferring user location. Experimental results showing the accuracy of the proposed system are presented.
The effect of combined exercise training on plasma Leptin levels and hormonal factors in overweight men

1 ،نارهت یکشزپ مولع هاگشناد ،یشزرو يژولویزیف دشرا یسانشراک ناریا ،نارهت . 2 ناریا ،درکرهش ،درکرهش هاگشناد ،یناسنا مولع و تایبدا هدکشناد ،یندب تیبرت هورگ ،یشزرو يژولویزیف رایشناد . 3 ناریا ،درکرهش ،درکرهش هاگشناد ،یناسنا مولع و تایبدا هدکشناد ،یندب تیبرت هورگ ،یشزرو يژولویزیف يرتکد يوجشناد . 4 رتویزیف یصصخت يارتکد ناریا ،نارهت ،نارهت یکشزپ مولع هاگشناد ،یپا . 5 ناریا ،نارهت ،نارهت یکشزپ مولع هاگشناد ،رامآ سانشراک . 6 ناریا ،نارهت ،نارهت یکشزپ مولع هاگشناد ،انیس ناتسرامیب ،مسیلوباتم و ددغ مولع هدکشهوژپ یقاچ هورگ ،یمومع کشزپ .
Management of overdoses of salvia, kratom, and psilocybin mushrooms: a literature review

ABSTRACT Introduction Despite the relative reduction in opioid and other illicit substance overdoses in the past few years, clinicians must remain vigilant in keeping up to date on emerging trends with regard to potential substances of abuse. As overdoses of traditional drugs of abuse decrease in light of legislative and de-prescribing initiatives, it stands to reason that alternative agents, including natural products, have increased. Toxicities associated with these agents have been contributing to emergency department visits across the globe. Areas covered This evaluation covers salvia, kratom, and psilocybin mushrooms, and was accomplished through a comprehensive review of PubMed, SCOPUS, ProQuest Central, ProQuest Dissertations, and CINAHL. Thirty-one pieces of literature are included in this evaluation. The objective of this review is to provide clinicians with the information necessary to provide bedside care for overdoses of salvia, kratom, and psilocybin mushrooms. Expert opinion Salvia, kratom, and psilocybin mushrooms may not be an initial consideration when healthcare practitioners are triaging an overdose scenario; however, data from around the world demonstrate an increased use of these agents. While not typically fatal, clinicians must be prepared to assess these as a potential etiology of overdoses and provide appropriate supportive care.
Analyses Phase in Development of the ScolioMedIS System

This paper focuses on analyses phase in development of the information system for monitoring, diagnosing and visualization of scoliosis ScolioMedIS. A major problem in healthcare information systems is the failure to understand institutional and individual user expectations and requirements. By analyzing the users' needs and requirements we concluded that the information system ScolioMedIS needs to have ability to record visual examination of patients with scoliosis using electronic scoliosis forms, based on an innovative protocol. Also, it should enable 2D and 3D visualizations of back-surface's point clouds, back symmetry line and middle spinal line, as well as automatic determination of Cobb angles and other relevant parameters for scoliosis in the frontal and sagittal planes. The system should be based on two non-invasive modalities: Formetric DIERS rasterstereography scanner and digital camera.
Broadband Frequency Reconfigurable Antenna Using Capacitive Loading for K-band Applications

A novel reconfigurable antenna in K-band frequency range is presented. The antenna employs a simple capacitive loading technique to increase the -10 dB bandwidth by 2.5 times (+150%). The proposed antenna is designed at the frequency of the unloaded state to operate at 24.2 GHz (bandwidth of 1.8 GHz) and the loaded state at 24.5 GHz (bandwidth of 4 GHz). Antenna gain of 12 dBi and 9 dBi for unloaded and loaded configuration, respectively, are recorded. The directivity of the antenna is optimized by using reflectors and directors. Radiation pattern distortion caused by capacitive loading is corrected by the use of a 14 mm thin dielectric lens. The design frequencies are used in automotive radar. A narrow band centered at 24.2 GHz is used for Adaptive Cruise Control (ACC) and Lane Change Radar (LCR). A broad bandwidth centered at 24.5 GHz is used for Short Range Radars (SRR). The proposed design shows an excellent agreement between the simulated and measured results.
Control of In Vitro Contamination of Explants from Field-grown Dabai (Canarium odontophyllum Miq.) Trees

Dabai (Canarium odontophyllum Miq.) is an indigenous fruit tree of Sarawak which has two sex forms. Seed-derived planting materials will not be true-to-type as it is difficult to distinguish sex of Dabai seedlings (male or hermaphrodite). In ad - dition, conventional vegetative propagation of Dabai is extremely difficult. This study was conducted to establish a protocol for control of in vitro contamination of explants from field-grown hermaphrodite Dabai trees for use in micropropagation of this species. New buds growth was observed two weeks after pruning of main branches of Dabai tree. Before wrapping with polyeth- ylene bags, new shoots were pre-treated with 70% ethanol, followed by spraying of 0.1% benomyl. An insecticide, i.e. Termitoff (50% v/v) was applied at the bases of main branches. Shoots were harvested after one week. Bud and shoot-tip explants were agitated respectively in 0.3% benomyl solution for 1 hour, 70% ethanol for 60 seconds and 25% Clorox added with Tween 20 for 15 minutes. After surface sterilisation, explants were cultured in solid MS basal medium supplemented with 2 ml/L Plant Preservative Mixture (PPMTM), 5 mg/L tetracycline and 0.3% activated charcoal. This treatment has resulted about 40% axenic explants.
Anonymous Key-Agreement Protocol for V2G Environment Within Social Internet of Vehicles

The blend of Internet of Things (IoT) and social networking has introduced the emerging notion of social Internet of Things, which is bringing advancements in the operation of concerned industries. There are various prevailing applications of social internet of things; smart grid is one of them. The smart grid is considered as economical robust and intuitive replacement of the conventional grid. However, smart grid experiences two significant challenges, i.e. privacy and security. This article is dedicated to resolve the privacy and security concerns for the vehicle to grid networks to facilitate their large-scale integration with smart grids. As anticipation, a vigorous key agreement protocol is introduced to achieve mutual authentication with an aided feature of user anonymity. Moreover, efficiency in terms of computation, communication and storage needs to be taken care for resource-constrained infrastructure like vehicle to grid network. We have introduced a lightweight key agreement protocol using lightweight cryptographic operations such as exclusive-OR and hash etc. This protocol is validated through a formal security model. An informal security analysis is also elaborated to present the security strength of our protocol against well-known attacks. Furthermore, we have implemented all the cryptographic operations used at trusted agent’s side on a desktop system, while the operations used at battery vehicle unit’s side are implemented on an Arduino to get the experimental results. In the end, we have presented a performance analysis to compare the performance of our protocol with related ones. This comparison highlights that our protocol is not only lightweight but also efficient in terms of communication and storage cost of related protocols.
secondary infection with Listeria monocytogenes

The role for neutrophils in the resolution of primary and secondary infection with Listeria monoyto- genes was studied. The results show that although control mice started to clear Listeria from their spleens and livers between days 2 and 4 of sublethal primary infection and eradicated bacteria in 2 weeks, mice given a specific granulocyte-depleting antibody (RB6-8C5) on days 4 or 6 of infection developed lethal listeriosis. Likewise, treat- ment of immunized mice with RB6-8C5 monoclonal anti- body abolished their acquired ability to resolve a lethal challenge infection. The results demonstrate that neutro- phils are necessary for the resolution of secondary and primary LiSteria infection. J. Leukoc. BiO1. 57: 827-83 1; 1995.
Active FSS Design using Multi-Resonators

In this paper, a method to design active frequency selective surfaces (AFSS) with the bandpass response in the lower frequency bands is proposed. The designed AFSS on a low cost 0.8 mm thick FR-4 substrate is capable to tune from 1.3 GHz-3.4 GHz in the TE mode of the impinging electromagnetic wave. The step wise step design procedure and its equivalent circuit model with the tuning capability has also been developed whose response is in close agreement to the proposed AFSS. To prove its novelty a state of the art comparison is also presented. Interestingly, the AFSS also tuned in the upper frequency band in the range of 9-13 GHz which along with the effect of angle of incidence and the measured results would be presented during the conference.
Survival of patients with newly diagnosed high-grade myeloid neoplasms who do not meet standard trial eligibility

Few patients with cancer, including those with acute myeloid leukemia and high-grade myeloid neoplasms, participate in clinical trials. Broadening standard eligibility criteria may increase clinical trial participation. In this retrospective single-center analysis, we identified 442 consecutive newly diagnosed patients from 2014 to 2016. Patients were considered “eligible” if they had a performance status 0-2, normal renal and hepatic function, no recent solid tumor, left ventricular ejection fraction (EF) ≥50%, and no history of congestive heart failure (CHF) or myocardial infarction (MI); “ineligible” patients failed to meet one or more of these criteria. We included 372 patients who received chemotherapy. Ineligible patients represented 40% of the population and had a 1.79-fold greater risk of death (95% Confidence Interval [CI]: 1.37-2.33) than eligible patients. Very few patients had cardiac comorbidities, including 2% with low EF, 4% with prior CHF, and 5% with prior MI. In multivariable analysis, ineligibility was associated with decreased survival (Hazard ratio [HR] 1.44; 95% CI: 1.07-1.93). Allogeneic transplantation, performed in 150 patients (40%), was associated with improved survival (HR 0.66, 95% CI: 0.48-0.91). Therefore, standard eligibility characteristics identify a patient population with improved survival. Further treatment options are needed for patients considered ineligible for clinical trials.
Hyaluronic acid-coated gold nanorods enhancing BMP-2 peptide delivery for chondrogenesis

Bone morphogenic protein-2 (BMP-2) knuckle epitope peptide has been recently discovered and known to activate chondrogenesis. However, the applications of this soluble peptide remain very limited due to rapid diffusion resulting in poor cellular uptake into target cells. We herein designed nanoparticles made from hyaluronic acid functionalized gold nanorods (GNRs) to conjugate with thiolated BMP-2 knuckle epitope peptide via a two-step reaction. Hyaluronic acid was modified to have thiol functional groups to replace the cetyl trimethylammonium bromide ligands on the surface of GNRs. The thiolated peptides were subsequently reacted with hyaluronic acid on the surface on GNRs via a maleimide-hydrazide crosslinker. The conjugation was confirmed by the change of surface charge of GNRs and the plasmon shift. A colorimetric peptide assay suggested more than 69% of the thiolated peptides were conjugated with the hyaluronic acid coated gold nanorods. Moreover, in vitro cell viability showed that BMP-2 conjugated hyaluronic acid functionalized gold nanorods (B2HGR) were cytocompatible and did not cause cytotoxicity to fibroblast cells. The B2HGRs also significantly promote cellular uptake of the BMP-2 peptides in both human mesenchymal stem cells and porcine chondrocytes due to multivalent ligand binding to the BMP receptors on the cell surface resulting in receptor-mediated endocytosis. The enhanced cellular uptake was clearly observed under a confocal microscope resulting in the significant activation of type II collagen gene expression and glucosaminoglycan secretion in those cells. Furthermore, our delivery system is a proof-of-concept of using scaffolds in combination with nanodelivery platform to enhance cartilaginous repair. The peptide loading capacity and the release is not limited by the scaffolds. Therefore, our delivery platform has potential applications for cartilage regeneration in a preclinical and clinical setting in the future.
Image Detection Technology on Pin Defect to Overhead Power Lines

To improve efficiency of UAV in routing inspection of overhead power lines as well as detection rate of pin defect to overhead power lines, the thesis proposes a method for detection of pin defect for UAV routing inspection of overhead power lines based on Faster-RCNN algorithm. In view of the fact that UAV routing inspection is characterized by large image background and tiny size of pin, the deep residual network ResNet101 is selected as pre-feature extraction network on the basis of Faster-RCNN and training image scale is increased. Experiments show that the method has a good performance in pin defect detection in UAV patrol image on test set. Compared with other prevailing object detection methods, the detection effect is better and the generalization ability is stronger.
General enumeration of RNA secondary structures based on new arc representation

We have presented a new arc representation, which differentiates the Watson-Crick base pairs between AU and GC. Based on the new representation, this paper also computes the number of various types of constrained secondary structures taking the minimum stack length 1 and minimum size m for each bonding loop as two parameters by virtue of the technique of generating function. Furthermore, asymptotes are derived from these recurrences relations, which are the generalizations of previous results. Keywords : RNA secondary structure, recurrence relation, generating function, asymptotic enumeration African Journal of Biotechnology Vol. 12(14), pp. 1576-1584
A Multi-Objective Natural Aggregation Approach Based Residential Energy Management with Photovoltaic Power Penetration

Residential energy management (REM) has drawn wide attention in demand side management research recent years. This paper proposed a multi-objective optimization approach for REM in a high photovoltaic solar power penetrated environment. The proposed model manages three kinds of residential energy resources (RERs): a rooftop photovoltaic source, a heating, ventilation and air conditioning (HVAC) system, and multiple controllable household appliances. The proposed model aims at achieving following three objectives: (1) to minimize the home electricity cost; (2) to maximize the indoor thermal comfort for the user; and (3) to maximize the usage convenience of non-thermal appliances. An adaptive thermal comfort model is employed to model the indoor thermal comfort degree of the user, and a user disturbance metric is proposed to measure the psychological disturbance of the household appliance operation on the user’s preference. A new multi-objective optimization solver, i.e., MultiObjective Natural Aggregation Algorithm (MONAA), is proposed to find the approximated Pareto frontier of the model. Simulations are conducted to validate the proposed method.
Monitoring and Adaptive Robust Protection of the Integrity of Inertial Satellite Observations

This paper is devoted to the problem of increasing the reliability of monitoring and localization of violations in inertial-satellite navigation system. Proposed solutions to the problem are based on the decomposition of diagnostic models of such systems and the use of combined statistical criteria. The results of full-scale experiments with the integrated inertial-satellite navigation system SINS-500NS are presented and analyzed.
Seasonal influence of brook trout and mottled sculpin on lower trophic levels in an Appalachian stream

Summary 1. In some situations fish have strong top-down effects in stream communities while in others they seem to be relatively unimportant. Differences in the impact of fish may depend on a variety of factors including the foraging mode of the fish, interactions among fish species and temporal variation in environmental conditions and species interactions. 2. We investigated the effect of brook trout (Salvelinus fontinalis) and mottled sculpin (Cottus bairdi) on lower trophic levels in Appalachian streams and whether or not interactions between these fish changed their influence. Mesocosms were placed in a headwater stream in a randomized complete block design. Within blocks, mesocosms were randomly assigned to one of the following treatments: (i) no fish; (ii) sculpin only; (iii) trout only and (iv) both sculpin and trout. Fish biomass was the same in all three fish treatments. Invertebrate density and algal biomass in mesocosms were determined after 3 weeks. We repeated the experiment in the autumn, spring and summer to test for seasonality of fish effects. 3. The effect of fish on invertebrate assemblages was seasonal and depended on prey identity. Sculpin strongly suppressed grazer abundance in spring while trout had little effect on grazers in any season. The influence of both fish on insect predators was similar and relatively constant across seasons. We found little evidence of an interaction between sculpin and trout that strongly influenced their effect on prey across seasons. 4. None of the fish treatments influenced algal biomass during any of the seasons. Algal growth was also seasonal, with a two- to four-fold increase in algal biomass in spring compared to autumn and summer. 5. Our results indicate that benthic and drift feeding fish differ in their effects on some, but not all prey. Furthermore, fish effects on prey were strongly seasonal for some, but not all prey types. While the temporal context is not commonly considered, our results indicate seasonality can be an important component of predator–prey interactions in streams.