Miracle-dz/UniFAR-FTUs huggingface dataset:
Asset management of Dutch social landlords

As part of a more general trend towards privatisation, deregulation and decentralisation of public tasks, housing policy in several Western and Eastern European countries aims to reinforce market-orientation in the social housing system. These reforms had a large impact on the asset management of public and social landlords. In the past, social housing was mainly concerned with the development of new dwellings. Management of the housing stock consisted first of all of day-to-day maintenance and administration. Strategic decisions about investments in the housing stock were mostly made by governments, rather than by individual landlords. Now, landlords in many countries are faced with the challenge to develop their own strategies. Although the precise effects on stock investment and allocation are yet to be determined, we may expect a more dynamic stock policy and an increased importance of market and financial considerations. In this paper, asset management in the Dutch social housing sector is described. The paper deals with rent policy, housing allocation and investment policy. Special attention is paid to rationalisation of decision making about the development of the housing stock. Recent research in this area shows various innovations, but also indicates that the formulation of a strategic asset management is still in its infancy.
Epidemiology of a primary pneumonic plague in Kantoshu, Manchuria, from 1910 to 1911: statistical analysis of individual records collected by the Japanese Empire.

BACKGROUND Among the potential uses of Yersinia pestis, intentional release of its aerosolized form, causing person-to-person transmission, is thought to be the most threatening. With the current rarity of pneumonic plague epidemics, our epidemiological knowledge remains insufficient for detailed characterization of effective control measures. METHODS Temporal patterns and key biological parameters of a pneumonic plague epidemic in Manchuria from 1910 to 1911 were analysed based on historical records collected by Kanto Totokufu, the administration of the Japanese Empire in Manchuria at that time. The serial intervals were fitted to gamma distribution using the maximum likelihood method, and time-delay distributions from onset-to-admission, admission-to-death, and onset-to-death were investigated. RESULTS Whereas a total of 228 cases were diagnosed with pneumonic plague in areas under direct control of the Japanese Empire, 4,781 cases were also recorded in surrounding areas. Although the epidemic grew exponentially in the early phase, the average doubling time steadily increased reflecting successful control efforts. The estimated mean serial interval (and standard deviation) was 5.7 (3.6) days. All cases with known dates of onset were admitted to hospital within 4 days after onset, and the mean time from onset to admission was 1.1 (0.4) days. CONCLUSIONS The increase in doubling time demonstrates the efficient and rapid countermeasures employed. Since the short interval from onset to death implies the importance of rapid responses, the challenge in confronting a future bioterrorist attack is to implement rapid and appropriate integration of control measures both at the individual and community level to prevent further transmissions as well as lower case fatality.
The power system load modeling based on recurrent RBF neural network

The accuracy of the load model has great effects on power system stability analysis and control. In order to solve the problem of the difficulty of establishing accurate load model and the complexity of the modeling the non-linear properties of dynamic load , this paper proposes a methodology based on the RRBFNN (recurrent RBF neural network) on modeling load from field measurements. New method is proposed to model power system load, which consists of recurrent network (RNN) and radial basic function (RBF) network and uses the ability of RNN for learning time series and the property of RBF with self-structuring and fast convergence. This new method which is tested by computer simulations on benchmark New Fngland test system and applied in model identification of composite load for power system, has been proved its validity and accuracy.
Exchange Rate Coordination in Asia: Evidence Using the Asian Currency Unit

This paper evaluates the extent of exchange rate coordination among Asian economies using a hypothetical Asian Currency Unit. Rising interdependence among Asian economies makes it vital for these economies to have a certain degree of exchange rate stability. However, the empirical evidence using an Asian Currency Unit suggests a widening deviation in exchange rate movements of the Asian currencies. The deviation has been driven by the adoption of different exchange rate regimes by the participating countries indicating diverse policy objectives.
Projections from the superior colliculus to the trigeminal system and facial nucleus in the rat

To determine the influence of the superior colliculus (SC) in orienting behaviors, we examined SC projections to the sensory trigeminal complex, the juxtatrigeminal region, and the facial motor nucleus in rats. Anterograde tracer experiments in the SC demonstrated predominantly contralateral colliculotrigeminal projections. Microinjections in the deep layers of the lateral portion showed labeled nerve fibers and terminals in the ventromedial parts of the caudal principal nucleus and of the rostral oral subnucleus and in the medial part of the interpolar subnucleus. Some terminals were also observed in the juxtatrigeminal region and in the dorsolateral part of the facial motor nucleus contralaterally, overlying the orbicularis oculi motoneuronal region. Verification by retrograde tracer injections into the trigeminal target regions showed labeled SC neurons mostly in lateral portions of layers 4–7. When the juxtatrigeminal region was involved, a remarkable increase of labeled neurons was observed, having a patch‐like arrangement with a decreasing gradient from lateral to medial SC portions. Retrograde tracer injections in the dorsolateral VII nucleus showed bilateral labeled neurons mainly in the deep lateral SC portion. Retrograde BDA microinjections into the same trigeminal or juxtatrigeminal regions, followed by gold‐HRP into the dorsolateral VII nucleus, demonstrated a significant number of SC neurons in deep layers 6–7 projecting to both structures by axon collaterals. These neurons are mediolaterally grouped in patches along the rostrocaudal SC extent; a subset of them are immunoreactive for glutamic acid decarboxylase (GAD). They could be involved in the coordination of facial movements. Simultaneous anterograde and retrograde tracer injections into the lateral SC portion and the VII nucleus respectively localized trigeminofacial neurons receiving collicular input in the trigeminal principal nucleus and pars oralis. Therefore the SC should play a crucial role in regulating motor programs of both eye and eyelid movements. J. Comp. Neurol. 478:233–247, 2004. © 2004 Wiley‐Liss, Inc.
[Detection and molecular epidemiology of respiratory syncytial virus type A and B strains in childhood respiratory infections in Hungary].

UNLABELLED Human respiratory syncytial virus (hRSV) is one of the major causes of respiratory infection of infants and children worldwide. The molecular epidemiology of hRSV is unknown in Hungary. AIMS Our aims were the molecular detection and genetic analysis of hRSV from childhood respiratory infections in Hungary. MATERIALS AND METHODS Nasopharyngeal aspirates were collected from children under the age of 10 years with acute respiratory infections provided by the Pediatric Department of the Hospital for Chest Diseases in Mosdós. Samples were taken from 15 October to 15 May in seasons of 2005/2006 and 2006/2007. The clinical and epidemiological data were collected prospectively. The amplification of the surface fusion glycoprotein (F) and the attachment glycoprotein (G) genes of viral RNA was made by RT-PCR method. PCR-products were sequenced and analyzed by phylogenetic analysis. RESULTS Nasopharyngeal aspirates of 104 children were examined out of which 23 (22.1%) samples - 16 males (69.6%) and 7 females (30.4%) - (first season: 1/49, 2%; second season: 22/55, 40%) contained hRSV. The hRSV infections were taking place from December to March. The average age was 2.1 years (1 month to 8 years). The leading symptoms were dropping nose, fever, cough and wheezing. Thirty-nine point one percent of the hRSV infected children had underlying disease. Based upon the F region 22 (96%), viruses genetically belonged to type A and 1 (4%) was classified as type B hRSV. Based upon the G region, out of the 11 type A viruses 8 (72.7%) belonged to group GA5 and 3 (27.3%) to group GA2. Viral nucleotide sequence was identical in several cases. CONCLUSIONS To our knowledge, this is the first report on molecular detection and genetic analysis of the two types (A and B) of hRSV of children under the age of 10 with respiratory infections in Hungary. In winter and spring hRSV is an important cause of childhood respiratory infections, particularly in infants, often requiring hospitalization.
Tissue‐specific metabolic activation and mutagenicity of 3‐nitrobenzanthrone in Muta™Mouse

3‐Nitrobenzanthrone (3‐NBA) is a mutagen and suspected human carcinogen detected in diesel exhaust, airborne particulate matter, and urban soil. We investigated the tissue specific mutagenicity of 3‐NBA at the lacZ locus of transgenic Muta™Mouse following acute single dose or 28‐day repeated‐dose oral administration. In the acute high dose (50 mg/kg) exposure, increased lacZ mutant frequency was observed in bone marrow and colonic epithelium, but not in liver and bladder. In the repeated‐dose study, a dose‐dependent increase in lacZ mutant frequency was observed in bone marrow and liver (2‐ and 4‐fold increase above control), but not in lung or intestinal epithelium. In addition, a concentration‐dependent increase in mutant frequency (8.5‐fold above control) was observed for Muta™Mouse FE1 lung epithelial cells exposed in vitro. 1‐Nitropyrene reductase, 3‐NBA reductase, and acetyltransferase activities were measured in a variety of Muta™Mouse specimens in an effort to link metabolic activation and mutagenicity. High 3‐NBA nitroreductase activities were observed in lung, liver, colon and bladder, and detectable N‐acetyltransferase activities were found in all tissues except bone marrow. The relatively high 3‐NBA nitroreductase activity in Muta™Mouse tissues, as compared with those in Salmonella TA98 and TA100, suggests that 3‐NBA is readily reduced and activated in vivo. High 3‐NBA nitroreductase levels in liver and colon are consistent with the elevated lacZ mutant frequency values, and previously noted inductions of hepatic DNA adducts. Despite an absence of induced lacZ mutations, the highest 3‐NBA reductase activity was detected in lung. Further studies are warranted, especially following inhalation or intratracheal exposures. Environ. Mol. Mutagen. , 2008. Published 2008 Wiley‐Liss, Inc.
'Innovation Profiler' - Identification and Prioritisation of Innovation Factors Based on Social Network Analysis

Innovation is essential for both economies and companies to ensure competitiveness in today’s global markets. While many companies struggle with this task, others seem to take maximum advantage of their resources. The difference between innovation leaders and less innovative organisations can be ascribed to a variety of factors such as innovation infrastructure or corporate culture. Given limited resources, companies need to prioritise their efforts to become and remain innovative. The ‘Innovation Profiler’ is a tool to undertaking an individual analysis of a company’s innovation infrastructure and behaviour. It takes into account not only success factors but identifies disruptive factors for the development of a robust innovation management. The ‘Innovation Profiler’ provides insights into interrelations between various factors in order to understand their individual impact on the innovation capability. Analytical measures to analyse complex interrelations are based on methods of social network analysis (SNA). As a result, organisations are enabled to leverage their innovative potential by focusing on selected factors that are identified as highly relevant for their specific innovation management.
Codes on Graphs: Models for Elementary Algebraic Topology and Statistical Physics

This paper is mainly a semi-tutorial introduction to elementary algebraic topology and its applications to Ising-type models of statistical physics, using graphical models of linear and group codes. It contains new material on systematic <inline-formula> <tex-math notation="LaTeX">$(n, k)$ </tex-math></inline-formula> group codes and their information sets; normal realizations of homology and cohomology spaces; dual and hybrid models; and connections with system-theoretic concepts, such as observability, controllability, and input/output realizations.
Modeling CNT Interfaces Using NEGF Approach

In this work we used SWCNT and GNRs, for the purpose of studying their applications as a nanoscale sensors. We assumed in this work that, under the simulated conditions, inelastic scattering processes were negligible and we were dealing with an effectively ballistic transport regime. The observations discussed above revealed the potential applications of carbon nano tube for measuring stress and temperature as well as in SWCNT can be used for wide range applications in design of a versatile nanoscale sensor. ————————————————————
Pertussis Toxin Modification of PC12 Cells Inhibits a Protein Phosphatase 2A‐Like Phosphatase

Abstract: We have found that modification of rat PC12 cells with pertussis toxin resulted in an ∼50% inhibition of a protein phosphatase 2A‐like phosphatase. Protein phosphatase 2A (PP2A) is a major cellular serine/threonine‐specific protein phosphatase. Treatment of extracts from pertussis toxin‐modified PC12 cells with either immobilized alkaline phosphatase or Ca2+ reversed this inhibition. Reactivation of the PP2A‐like phosphatase in Ca2+ appears to result from the dephosphorylation of a protein by the Ca2+/calmodulin‐dependent protein phosphatase calcineurin. The PP2A‐like phosphatase in extracts from pertussis toxin‐modified PC12 cells eluted from a Mono Q column at a higher ionic strength than did the PP2A‐like phosphatase in extracts from control cells. After incubation in Ca2+, the PP2A‐like phosphatase in extracts from pertussis toxin‐modified cells eluted from a Mono Q column at the same ionic strength as did the PP2A‐like phosphatase in extracts from control cells. These results indicate that the effect of pertussis toxin on this PP2A‐like activity results from the phosphorylation of either one of the subunits of the PP2A‐like phosphatase or a protein that when phosphorylated binds to and inhibits this phosphatase. Pertussis toxin modification did not result in the phosphorylation of the catalytic subunit of PP2A. Because phosphorylation regulates the activities of many enzymes and cell surface receptors, a pertussis toxin‐induced decrease in PP2A activity could alter signaling pathways and other cellular processes in which G proteins are not directly involved.
Management of Anemia in CKD: A Review

Chronic Kidney Disease leads to progressive failure to the kidney. If untreated, a number of complications may arise such as anemia, hyperlipidemia, cardiovascular disease. Renal anemia is highly prevalent in CKD patients (both in dialysis and nondialysis). Anemia can be managed by using either Erythropoietin Stimulating Agent (ESA) or by IV iron therapy. Recombinant human erythropoietin (rHuEPO) is widely used ESA to treat anemia. Hemoglobin (Hb) variation can be controlled by using these agents. The IV iron therapy is also considered a standard care in anemia management because it can reduce the exposure to ESA. Anemia contributes to increases morbidity, mortality and poor quality of life. Treating anemia mainly in dialysis patients with ESA reduces the risk of blood transfusion and increase the patient quality of life. This is because it can cause either hyporesponsivenes or erythropoietin resistance. Another recently discovered drug Roxadustat is a promising therapeutic approach against anemia in CKD. The hemoglobin response of roxadustat is independent of inflammatory microenvironment.
A longitudinal study of corporate earnings guidance in Australia’s continuous disclosure environment

Since the introduction of a statutory‐backed continuous disclosure regime (CDR) in 1994, regulatory reforms have significantly increased litigation risk in Australia for failure to disclose material information or for false and misleading disclosure. However, there is almost no empirical research on the impact of the reforms on corporate disclosure behaviour. Motivated by the absence of research and using management earnings forecasts (MEFs) as a disclosure proxy, this study examines (1) why managers issue earnings forecasts, (2) what firm‐specific factors influence MEF characteristics, and (3) how MEF behaviour changes as litigation risk increases. Based on theories in information economics, a theoretical framework for MEF behaviour is formulated which includes antecedent influencing factors related to firms‟ internal and external environments. Applying this framework, hypotheses are developed and tested using multivariate models and a large sample of hand-collected MEFs (7,213) issued by top 500 ASX-listed companies over the 1994 to 2008 period. The results reveal strong support for the hypotheses. First, MEFs are issued to reduce information asymmetry, litigation risk and signal superior performance. Second, firms with better financial performance, smaller earnings changes, and lower operating uncertainty provide better quality MEFs. Third, forecast frequency and quality (accuracy, timeliness and precision) noticeably improve as litigation risk increases. However, managers appear to be still reluctant to disclose earnings forecasts when there are large earnings changes, and an asymmetric treatment of news type continues to prevail (a good news bias). Thus, the findings generally provide support for the effectiveness of the CDR regulatory reforms in improving disclosure behaviour and will be valuable to market participants and corporate regulators in understanding the implications of management forecasting decisions and areas for further improvement.
Overview of context-sensitive technologies for well-being

Today smart devices such as smartphones, smartwatches and activity trackers are widely available and accepted in most developed societies. These devices present a broad set of sensors capable of extracting detailed information about different situations of daily life, which, if used for good, have the potential to improve the quality of life not only for individuals but also for the society in general. One of the key areas where this type of information can help to improve the quality of life is in healthcare since it allows to monitor and infer the current level of well-being of the smart devices carriers. In this paper, some of the available literature about well-being sensing through context-aware data is reviewed. Also, the main types of mechanisms used in these studies are identified. These mechanisms are related to monitoring, generalization, inference, feedback, energy management and privacy. Furthermore, a description of the mechanisms used in each study is presented.
Survey of central banks' views on effects of intervention

This paper addresses two main issues. First, how do central banks in the emerging market economies assess the effects of their foreign exchange interventions on the exchange rate? Second, how do they view other external effects of intervention, such as the relationship between intervention, reserve accumulation and external vulnerabilities, and the usefulness of additional rules on foreign exchange transactions? The analysis in the paper is based on central bank responses to a BIS questionnaire prepared for this meeting, interviews with central bank staff, and studies of intervention prepared by central banks from emerging market economies.
Efficient Structure of Provision for Emergency Public Services

We consider an economy in which a central government has to decide on the provision and location of an emergency public service the quality of which diminishes with distance. The emergency service has to attend a group of municipalities geographically located in a star-tree-graph. We derive the optimal location and provision, as well as the Lindahl prices for the emergency service. Also, we determine the minimum quality of service that makes efficient the existence of a unique provider for the whole economy. Conversely, given any level of quality of service we identify the stable and efficient structure of provision.
Identification of monoclonal nonspecific suppressor factor beta (mNSFβ) as one of the genes differentially expressed at implantation sites compared to interimplantation sites in the mouse uterus

Successful implantation requires synchronous development of and active dialogue between the maternal endometrium and the implanting blastocyst. While it is well established that appropriate maternal steroid hormones are essential for endometrial preparation for implantation, the molecular events at the actual site of implantation are still little understood. The aims of our studies were to identify genes explicitly expressed or repressed at the sites of implantation by utilising RNA differential display (DDPCR), and to establish the roles of these genes in the implantation process in a mouse model. Ten bands unique in implantation sites compared to interimplantation sites were identified by DDPCR and subsequently confirmed by Northern blotting. One of these bands contained a cDNA fragment that was highly homologous to mouse monoclonal nonspecific suppressor factor beta (MNSFβ) or Fau. The full cDNA sequence of this gene, obtained by screening a λgt11 cDNA library, was essentially the same as MNSFβ, except that it had much longer 5′ untranslated region. Interestingly, both Northern and immunohistochemical analysis showed that the expression of this gene was much lower in implantation sites compared to interimplantation sites on day 4.5 of pregnancy, when embryos first attach to the uterus and initiate implantation, and on day 5.5, when implantation has advanced. These results suggest a role for MNSF during implantation and early pregnancy, possibly through regulating the proliferation and/or differentiation of uterine stromal cells. It may also be involved in the selective production of TH2‐type cytokines in implantation sites to regulate the immune system at the maternal‐fetal interface. Mol. Reprod. Dev. 55:351–363, 2000. © 2000 Wiley‐Liss, Inc.
Neoadjuvant and adjuvant therapy with imatinib for locally advanced gastrointestinal stromal tumors in eastern Indian patients.

BACKGROUND Imatinib mesylate is able to at least modify the course of gastrointestinal stromal tumours (GISTs). Neoadjuvant use for locally advanced lesions is evolving as a new treatment paradigm in this hitherto universally fatal disease. METHODS AND RESULTS The study patients with locally advanced GIST received neoadjuvant and adjuvant imatinib mesylate. Response was noted as per the RECIST protocol and overall progression free survival was reported. Of 19 patients (mean age 38.5 years, range 26 yrs to 64 yrs) studied, 13 achieved partial response (PR) and 6 a stationary disease (SD) on preoperative imatinib. Histopathological evaluation and grading of responses revealed only moderate and low grade pathological response after imatinib. R0 resection was possible in 13/19 and R1 in 6/19. Imatinib was well tolerated and adverse reactions were minimal. Post operative complications of surgery were not out of the ordinary for a surgical series featuring extensive abdominal surgery. CONCLUSION Preoperative imatinib in locally advanced GIST seems to be a reasonable option for locally advanced GIST patients and enough downstaging to allow a resection with microscopically negative margins can be expected in a fairly good proportion of patients.