Miracle-dz/UniFAR-FTUs huggingface dataset:
EVALUACIÓN DE UN RECUBRIMIENTO ANTICORROSIVO A BASE DE POLIESTIRENO EXPANDIDO RECICLADO

El desarrollo de recubrimientos anticorrosivos en la actualidad busca la reutilizacion de las grandes cantidades de polimeros desechados, entre los que destaca el poliestireno. Esta investigacion tuvo como objetivo evaluar un recubrimiento anticorrosivo formulado en base a poliestireno expandido reciclado. Se desarrollaron dos formulaciones patron con poliestireno expandido reciclado como resina, D-limoneno como disolvente, TiO2 pigmento carga, ZnO agente anticorrosivo y octoato de cobalto como secante. Se evaluaron sus propiedades fisicas, quimicas y reologicas en referencia a la Norma Tecnica Ecuatoriana NTE INEN 1045 “Pinturas anticorrosiva. Esmalte alquidico brillante. Requisitos”. Los resultados muestran que la formulacion 2 da mejores resultados en funcion de su un tiempo de secado al tacto (63,84 min), viscosidad (715,80 cP), porcentaje de adherencia (96,00 %), limpieza en vidrio y porcentaje de solidos (39,50 %). Adicionalmente, se comparo la resistencia a la corrosion del recubrimiento obtenido versus un recubrimiento comercial, mediante la exposicion al ambiente salino de la playa las Palmas de la ciudad de Esmeraldas de placas de acero al carbono, acero inoxidable 304L y tol negro tratadas con ambos recubrimientos y aplicando la tecnica de perdida de peso. La velocidad de corrosion en las muestras donde se aplico el recubrimiento de poliestireno, en milesimas de pulgadas por ano (mpy), fueron 0,859 para el tol negro, 0,259 para acero al carbono y 0,064 para acero inoxidable 304L en base a la norma ADTM D-610 usando imagenes estandarizadas. Lo que evidencia el potencial del polimero reciclado como resina para recubrimiento anticorrosivo.
Identificación de biomarcadores relacionados con la transición epitelio-mesénquima y caracterización de modelos celulares tridimensionales in vitro en cáncer de ovario avanzado

El cancer de ovario se asocia a una elevada mortalidad, principalmente debido a que se diagnostica en fases avanzadas de la enfermedad, y a que, pese a tener una elevada tasa de respuesta al tratamiento inicial, en una mayoria de los casos, se acabara produciendo una recidiva. El proceso de la transicion epitelio mesenquima (TEM) hace referencia a un proceso altamente regulado que implica un cambio fenotipico por el cual las celulas pasan de tener caracteristicas epiteliales a mesenquimales, afectando a su crecimiento, migracion e invasion, y se relaciona con la agresividad tumoral y el desarrollo de metastasis. El estudio molecular de genes relacionados con la TEM en una cohorte de 84 pacientes con carcinoma de ovario avanzado, mediante RT-qPCR en tarjetas microfluidicas, ha identificado dos perfiles de expresion genica, uno para supervivencia libre de progresion (SLP), compuesto de 10 genes, y otro para supervivencia global (SG), compuesto por 6 genes. Los estudios de expresion proteica en estos tumores sugieren que HIF-2α, Snail y SPARC pueden representar biomarcadores con significado pronostico en el carcinoma de ovario. Por otro lado, los modelos in vitro para el estudio de la biologia molecular del cancer han evolucionado en las ultimas decadas, permitiendo solventar algunos de sus inconvenientes, como es la carencia de arquitectura tisular, con la utilizacion de modelos tridimensionales (3D). En este trabajo se han establecido estos modelos a partir de un panel de 16 lineas celulares de cancer de ovario, y se han caracterizado exhaustivamente en cuanto a sus propiedades basales y a la expresion de marcadores de TEM. Estos ensayos in vitro han confirmado la heterogeneidad de estas lineas celulares poniendo de manifiesto, por un lado, la necesidad de seleccionar minuciosamente los modelos preclinicos en base a los objetivos de cada estudio y por otro, que, dada la peculiar via de diseminacion en estos tumores, los modelos 3D representan un buen sistema alternativo para su estudio, sobre todo en cuanto al comportamiento farmacologico. Nuestros resultados in vitro indican que SLC39A6 podria estar relacionado con fenomenos de resistencia a platino y recaida. En todo caso, estos resultados deben ser interpretados con cautela y seran necesarios estudios prospectivos de validacion en series independientes, asi como estudios funcionales in vitro para confirmar su valor pronostico.
A co-evolutionary relationship exists between Endoraecium (Pucciniales) and its Acacia hosts in Australia

Endoraecium is a genus of rust fungi that infects several species of Acacia in Australia, South-East Asia and Hawaii. This study investigated the systematics of Endoraecium from 55 specimens in Australia based on a combined morphological and molecular approach. Phylogenetic analyses were conducted on partitioned datasets of loci from ribosomal and mitochondrial DNA. The recovered molecular phylogeny supported a recently published taxonomy based on morphology and host range that divided Endoraecium digitatum into five species. Spore morphology is synapomorphic and there is evidence Endoraecium co-evolved with its Acacia hosts. The broad host ranges of E. digitatum, E. parvum, E. phyllodiorum and E. violae-faustiae are revised in light of this study, and nine new species of Endoraecium are described from Australia based on host taxonomy, morphology and phylogenetic concordance.
Scattering analysis of active FSS structures using spectral-element time-domain method

Active frequency selective surface (FSS) structure is a kind of electromagnetic spatial filter, which has been widely used in the communication and radar systems. The spectral-element time domain method has been used to analyze the scattering characteristic of finite planar FSS structures. It has the advantages of spectral accuracy and block-diagonal mass matrix. This technique is based on Gauss-Lobatto-Legendre polynomials and Galerkin's method is used for spatial discretization. The absorbed boundary condition is employed to truncate the boundary. Numerical results demonstrate the accuracy of the method.
Epidemic adenoviral lower respiratory tract infection in pediatric patients: radiographic and clinical characteristics.

OBJECTIVE This retrospective study was undertaken to evaluate the radiographic and clinical findings of adenoviral lower respiratory infection during an epidemic period. CONCLUSION Epidemic adenoviral pneumonia may mimic bacterial pneumonia on radiographs. Findings that include bilateral and multifocal involvement on chest radiographs, normal or decreased WBC associated with lymphocytosis, and progression of illness despite extensive antibiotic therapy, help to differentiate epidemic adenoviral from bacterial pneumonia.
Dynamic Resource Scheduling for C2 Organizations Based on Multi-Objective Optimization

The dynamic resource scheduling problem is a field of intense research in command and control organization mission planning. This paper analyzes the emergencies in the battlefield first and divides them into three categories: the changing of task attributes, reduction of available platforms, and change in the number of tasks. To deal with these emergencies, in this paper, we built a series of multi-objective optimization models that maximizes the task execution quality and minimizes the cost of plan adjustment. To solve the model, we proposed an improved multi-objective evolutionary algorithm. A type of mapping operator and an improved crowding-distance sorting method are designed for the algorithm. Finally, the availability of the model and the solving algorithm were proved through a series of experiments. The Pareto frontier for the multi-objective dynamic resource scheduling problem can be found effectively, and the algorithm proposed in this paper shows better convergence compared with the AMP-NSGA-II algorithm.
The Effects of Web-Based Diabetes Education on Diabetes Care Results: A Randomized Control Study

This study aimed to test the effects of providing Web-based diabetes education to individuals with type 2 diabetes on the A1c level and health check attendance. The study participants comprised 122 individuals with type 2 diabetes, who had access to the Internet, had completed their basic diabetes education, and had similar basic situational factors. Using a randomization method, these participants were chosen from the patients being monitored by the diabetes nurses. The experimental group (n = 61) was monitored via the Web. From measurements recorded in the sixth month of monitoring, we found that A1c levels of the individuals with diabetes who were monitored through the Web decreased (t = 6.63; P < .05), and the rate of attending health check visits increased (z = 5.97; P< .05), while no difference was detected in the control group (t = −0.63; P = .534; z = −0.80; P = .426). To maintain glycemic control, Web use could be adopted as a complementary tool for monitoring individuals with diabetes.
The cerebellum and neuropsychological functioning: A critical review

The cerebellum, while once considered a brain region principally involved in motor control and coordination, is increasingly becoming associated with a range of neuropsychological and neuropsychiatric presentations. This paper reviews the dominant neuropsychological domains and neuropsychiatric conditions for which cerebellar involvement has been demonstrated, including visuospatial functioning, learning and memory, language, executive functioning, attention-deficit/hyperactivity disorder, autism spectrum disorders, and schizophrenia. The paper concludes with a discussion of a potential neuropsychological localization model within the cerebellum and a discussion of prognosis and rates of recovery that can be expected, following localized cerebellar lesions.
Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT2C antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study

Agomelatine (S 20098) has a unique and new pharmacological profile. It is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. The aim of this study was to determine the active dose of agomelatine in the treatment of major depressive disorder (DSM-IV criteria). The methodology used was a conventional double-blind design comparing three different doses of agomelatine (1, 5 and 25 mg once a day) with placebo over an 8-week treatment period. Paroxetine was used as the study validator. Seven hundred and eleven patients with a baseline mean score of 27.4 on the 17-item Hamilton Rating Scale for Depression (HAM-D) were included. On the pivotal analysis, the mean final HAM-D total score (Full Analysis Set LOCF) demonstrated agomelatine 25 mg to be statistically more effective than placebo. This was confirmed by other analyses and criteria (responders, remission, subpopulation of severely depressed patients, Montgomery–Åsberg Depression Rating Scale, Clinical Global Impression-Severity of Illness). Agomelatine 25 mg alleviated the anxiety associated with depression, as measured on Hamilton Anxiety Scale. Paroxetine was found to be effective on pivotal analysis and most of the secondary criteria used to validate the study methodology and population. Agomelatine, whatever the dose, showed good acceptability with a side-effects profile close to that of placebo. In conclusion, this study demonstrates that agomelatine is efficient in the treatment of major depressive disorder and that 25 mg is the target dose.
Supporting Human Health: Focusing Effective Built Environment Interventions

The built environment has an important role to play in supporting human health as part of everyday living. While this is increasingly recognised in a burgeoning inter-disciplinary body of literature, there is ongoing difficulty in defining the most effective built environment interventions that support human health. This paper proposes a way forward. We suggest three domains where planning can focus its support for human health by addressing the principle risk factors for contemporary chronic disease – physical inactivity, obesity and social isolation. First, the built environment can increase opportunities for, and reduce barriers to physical activity. The varying needs of different population groups, the purpose of the activity (transportation or leisure), and the characteristics of the built environment (such as residential and commercial densities, land use mix, connectivity and accessibility) must be considered in understanding how the environment can best support physical activity. Second, communities can be strengthened and connected by facilitating interaction in public spaces including gardens, town squares, parks and lively streetscapes. Such spaces have to be safe, inviting and meaningful for the communities that they serve. And third, through zoning and land use regulation, the built environment can support healthy eating. Interventions include community gardens and fresh food markets, as well as protecting food production systems and controlling marketing and advertising infrastructure, and food retail outlets. Our paper, based on a systematic literature review, establishes an evidence base that supports the development, prioritisation and implementation of healthy built environment policies and practices through the three identified domains.
The structure of uridylate kinase with its substrates, showing the transition state geometry.

Uridylate kinase from Saccharomyces cerevisiae is a member of the nucleoside monophosphate (NMP) kinase family and catalyzes the reaction ATP+NMP<==>ADP+NDP with moderate specificity for UMP. The recombinant enzyme crystallized together with two substrate molecules. The structure was solved, by multiple isomorphous replacement and solvent flattening, at 3.0 A and then refined at 2.13 A resolution. The present R-factor is 19%. Superposition onto the structure of a substrate-free adenylate kinase revealed the motions induced by substrate binding. A further superposition onto an adenylate kinase with bound P1,P5-bis(5'-adenosyl)pentaphosphate (Ap5A), a two-substrate-mimicking inhibitor, failed to explain the UMP preference of the uridylate kinase, but superimposed the nucleosides and in particular the non-transferred phosphates at the ATP- and NMP-site rather well. The coincidence of the phosphates indicate strongly that these groups assume their final positions during catalysis. This locates the transition state, which can be modeled with reasonable geometry in agreement with an in-line associative SN2 mechanism.
Characterization of premature liver polyploidy in DNA repair (Ercc1)‐deficient mice

ERCC1‐XPF is the endonuclease that cuts 5′ of the damage in nucleotide excision repair (NER). Unlike other NER proteins, ERCC1‐XPF is also involved in recombination and the repair of DNA interstrand cross‐links. Unique among the NER gene knockouts, Ercc1 null mice are severely runted with high levels of hepatocyte polyploidy. To understand the link between DNA repair deficiency and polyploidy we have compared the premature polyploidy in Ercc1 null liver with the normal development of polyploidy in aging control mice. Polyploidy was accelerated dramatically in Ercc1 null hepatocytes, such that ploidy levels were equivalent in 3‐week‐old Ercc1 null and 1‐ to 2‐year‐old wild‐type mouse liver. Levels of the cyclin‐dependent kinase inhibitor, p21, were increased in the nuclei of Ercc1 null hepatocytes, and this increase was concentrated in, but not confined to, the polyploid hepatocytes. Much lower levels of p21 messenger RNA (mRNA) were found in old wild‐type liver with equivalent levels of ploidy. We suggest that the more rapid accumulation of DNA damage in Ercc1 null liver leads to an increase in p21 levels, but that there is not a simple direct link between p21 levels and premature polyploidy. The failure to observe any link between p21 levels and polyploidy in aged wild‐type liver may be attributable to the much lower levels of accumulated DNA damage, the much greater timescale involved, or the existence of a p21‐independent mechanism for polyploidy. In conclusion, the premature polyploidy in Ercc1‐deficient liver differs from the normal aging‐related process. (Hepatology 2003;38:958–966).
The hydrogen exchange core and protein folding

A database of hydrogen‐deuterium exchange results has been compiled for proteins for which there are published rates of out‐exchange in the native state, protection against exchange during folding, and out‐exchange in partially folded forms. The question of whether the slow exchange core is the folding core (Woodward C, 1993, Trends Biochem Sci 18:359–360) is reexamined in a detailed comparison of the specific amide protons (NHs) and the elements of secondary structure on which they are located. For each pulsed exchange or competition experiment, probe NHs are shown explicitly; the large number and broad distribution of probe NHs support the validity of comparing out‐exchange with pulsed‐exchange/competition experiments. There is a strong tendency for the same elements of secondary structure to carry NHs most protected in the native state, NHs first protected during folding, and NHs most protected in partially folded species. There is not a one‐to‐one correspondence of individual NHs. Proteins for which there are published data for native state out‐exchange and ϕ values are also reviewed. The elements of secondary structure containing the slowest exchanging NHs in native proteins tend to contain side chains with high ϕ values or be connected to a turn/loop with high ϕ values. A definition for a protein core is proposed, and the implications for protein folding are discussed. Apparently, during folding and in the native state, nonlocal interactions between core sequences are favored more than other possible nonlocal interactions. Other studies of partially folded bovine pancreatic trypsin inhibitor (Barbar E, Barany G, Woodward C, 1995, Biochemistry 34:11423–11434; Barber E, Hare M, Daragan V, Barany G, Woodward C, 1998, Biochemistry 37:7822–7833), suggest that developing cores have site‐specific energy barriers between microstates, one disordered, and the other(s) more ordered.
Medication non‐adherence in the adolescent renal transplant recipient: A clinician's viewpoint *

Abstract: Recent advancements in immunosuppression and surgical techniques have significantly improved the outcome of kidney transplantation in the pediatric population. Adolescents enjoy the best 1‐year graft survival of any age group. However, the long‐term transplant outcome in adolescents is disappointing. Non‐adherence with immunosuppressive medications is one of the most important contributing factors for graft rejection and loss in teenagers. The impact of non‐adherence is perceived to be far more powerful in adolescent transplant recipients than in the transplant population as a whole. To better understand adolescent non‐adherence, the process of transplantation must be placed in the context of adolescent development. Adolescents try to establish their identity and autonomy separately from the parents; however at the same time, adolescents with chronic illness require help, support and guidance from adults, including parents and medical personnel. Adolescents have limited ability to anticipate abstractly the long‐term consequences of their immediate actions. This inconsistency can create frustration in both adolescents and in the supporting systems around them. Despite the significant consequences of adolescent non‐adherence, research in this area is scarce. There are still no established definitions, standardized diagnostic methods and effective interventions to treat and prevent this problem. We propose the recommendations to approach the problems of adolescent transplant non‐adherence from the transplant clinician's viewpoint. With early identification and appropriate interventions, significant improvement in adolescent graft survival is possible.
A V-Band CMOS VCO With an Admittance-Transforming Cross-Coupled Pair

A novel circuit topology suitable for the implementation of CMOS voltage-controlled oscillators (VCOs) at millimeter-wave frequencies is presented in this paper. By employing transmission line segments to transform the admittance of the additional cross-coupled pair, the proposed LC-tank VCO can sustain fundamental oscillation at a frequency close to the fmax of the transistors. Using a standard 0.18 mum CMOS process, a V-band VCO is realized for demonstration. The fabricated circuit exhibits a frequency tuning range of 670 MHz in the vicinity of 63 GHz. The measured output power and phase noise at 1 MHz offset are -15 dBm and -89 dBc/Hz, respectively. Operated at a 1.8 V supply voltage, the VCO core and the output buffer consume a total DC current of 55 mA.
Factors Influencing Survival After Total Pancreatectomy in Patients with Pancreatic Cancer

A retrospective analysis of factors influencing short-term and long-term survival after total pancreatectomy for pancreatic cancer was done in 86 patients. Among the 41 factors studied, hospital mortality was significantly affected by age over 70 years, preoperative diabetes, pain as presenting symptom, S-bilimbin, preoperative bile drainage, prophylactic antibiotic treatment, stage of the tumor, and experience of the surgeon. The only factors which had a statistically significant influence on long-term survival were stage of the tumor and sex of the patient. It is concluded that improvement of long-term survival can mainly be achieved by earlier identification and removal of the tumors and by introduction of more efficient adjuvant therapy. Whereas these goals probably will require a long time to be reached, the majority of factors associated with worsening of hospital mortality may be avoided by a strict selection of the patient, the tumor and the surgeon.
Group registration for reducing signaling traffic in location tracking

In this paper, a new location registration strategy - group registrations for mobile networks is proposed, in which instead of sending a location registration request to the home location register (HLR) for each registration area (RA) change of a mobile terminal (MT), the identifications of the MTs newly moving into an RA are buffered and sent to the HLR for location registration when the next incoming call to the RA occurs, i.e., the buffered MT identifications are forwarded to the HLR in the route response message of the call. Upon RA change, a forwarding pointer is set up from the MT's local anchor to its new visitor location register (VLR), so that incoming calls to the MT can be delivered before the MT's local anchor is changed to its current VLR via the next group registration. An analytic model is developed and numerical results are presented. It is revealed that compared to the conventional RA-based location registration scheme, the group registration strategy can achieve a significant cost savings over a wide range of system parameters.