Miracle-dz/UniFAR-FTUs huggingface dataset:
The Analysis of Earnings Persistence Roles in Mediating The Effect of Operating Cash Flow and Debt Level on Stock Return

Penelitian ini bertujuan untuk menganalisis pengaruh arus kas operasi dan tingkat hutang terhadap return saham, serta menganalisis peran persistensi laba dalam memediasi pengaruh arus kas operasi dan tingkat hutang terhadap return saham. Populasi dalam penelitian ini adalah 40 perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2010-2014. Pengambilan sampel dengan metode purposive sampling, dihasilkan sampel sebanyak 41 unit analisis. Pengujian penelitian ini dilakukan dengan teknik analisis regresi linear berganda dan sobel test dengan bantuan program IBM SPSS Statistics 21. Hasil penelitian ini menunjukkan bahwa arus kas operasi dan tingkat hutang tidak berpengaruh signifikan terhadap return saham, persistensi laba tidak memediasi secara signifikan pengaruh arus kas operasi terhadap return saham, dan persistensi laba mampu memediasi secara signifikan pengaruh tingkat hutang terhadap return saham. The aims of this research are to analyze the impact of operating cash flow and leverage toward stock return, to analyze the role of earning persistence mediates the impact of operating cash flow and leverage toward stock return. The population of this research are 40 listed mining firms in Indonesia Stock Exchange (BEI) for the period 2010-2014. Data were selected by purposive sample, it obtained 41unit analysis for the sample of the research. Multiple linear regression analysis and sobel test techniques was used to analyse data, and it was helped by IBM SPSS Statistics 21 software. The findings shows that operating cash flow and leverage didn’t have significant impact toward stock return, earning persistence didn’t mediate significantly the impact of operating cash flow toward stock return, and earning persistence mediated significantly the impact of leverage toward stock return.
Race and Class in the News: How the Media Portrays Gentrification

Author(s): Rucks-Ahidiana, Zawadi | Abstract: Whether it is affordable housing, health insurance, or crime, how a social problem is associated with race and class contributes to how the general public and policymakers respond to it. The media both informs and reinforces readers’ perceptions about what happens when social processes like gentrification take place, who is affected, and whether this type of change is positive or negative. Media representations can thus influence public perception, policy framing, and local policies around urban development. This paper uses articles published between 1990 and 2014 in two San Francisco newspapers to document how the process of gentrification is described. Using text analysis and qualitative coding, I find that race and class pervade reporting on gentrification in San Francisco. Gentrification was presented as a process by which the middle-class and whites move into predominantly black and low-income neighborhoods, even though the process of gentrification in San Francisco is significantly more complex. Although the news coverage raised more concerns about gentrification than benefits overall, some neighborhoods (working-class and Latino) receive greater attention and concern than others (poor and black). The result is an oversimplified and skewed portrait of who benefits and who loses as a result of gentrification in San Francisco. This skewed portrait will likely reinforce a common perception of gentrification as a solution to social ills associated with black and poor neighborhoods such as urban disinvestment and crime, rather than a process that reduces affordable housing and displaces low-income, long-term residents.
Vitamin A Supplementation Reduces IL‐17 and RORc Gene Expression in Atherosclerotic Patients

Vitamin A is a potential mediator of T helper cells in atherosclerosis. The purpose of this study was to evaluate the effect of vitamin A supplementation on expression of Th17 cells‐related IL‐17 and RORc genes in atherosclerotic patients. Thirty one atherosclerotic patients and 15 healthy controls were studied for 4 months. Atherosclerotic patients were randomly divided into vitamin A or placebo groups. Healthy controls and patients in vitamin A group received 25,000 IU retinyl palmitate per day. Peripheral blood mononuclear cells were isolated, cultured and divided into three groups including fresh cells, phytohemagglutinin (PHA)‐activated T cells and ox‐LDL‐activated T cells. Gene expressions of T cells were studied by real‐time PCR. In atherosclerotic patients, vitamin A supplementation resulted in significant decrease in IL‐17 gene expression by 0.63‐fold in fresh cell, 0.82‐fold in PHA‐activated cells and 0.65‐fold in ox‐LDL‐activated cells (P < 0.05 for all). RORc gene expression in fresh cells as well as ox‐LDL‐activated cells decreased significantly after vitamin A supplementation in atherosclerotic patients (P = 0.0001 for both). In PHA‐activated cells, vitamin A supplementation significantly decreased RORc gene in both atherosclerotic patients and healthy subjects by 0.87‐fold and 0.72, respectively, while in placebo group, the RORc gene expression significantly increased by 1.17‐fold (P < 0.05 for all). Findings of this study suggest that vitamin A supplementation may be an effective approach to slow progression of atherosclerosis.
Hepatitis C Virus Core and Nonstructural Protein 3 Proteins Induce Pro- and Anti-inflammatory Cytokines and Inhibit Dendritic Cell Differentiation1

Antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th cells by innate immune cells. In this study, we demonstrate that hepatitis C virus (HCV) core and nonstructural protein 3 (NS3), but not envelope 2 proteins (E2), activate monocytes and myeloid dendritic cells (DCs) and partially reproduce abnormalities found in chronic HCV infection. HCV core or NS3 (not E2) triggered inflammatory cytokine mRNA and TNF-α production in monocytes. Degradation of I-κBα suggested involvement of NF-κB activation. HCV core and NS3 induced production of the anti-inflammatory cytokine, IL-10. Both monocyte TNF-α and IL-10 levels were higher upon HCV core and NS3 protein stimulation in HCV-infected patients than in normals. HCV core and NS3 (not E2) inhibited differentiation and allostimulatory capacity of immature DCs similar to defects in HCV infection. This was associated with elevated IL-10 and decreased IL-2 levels during T cell proliferation. Increased IL-10 was produced by HCV patients’ DCs and by core- or NS3-treated normal DCs, while IL-12 was decreased only in HCV DCs. Addition of anti-IL-10 Ab, not IL-12, ameliorated T cell proliferation with HCV core- or NS3-treated DCs. Reduced allostimulatory capacity in HCV core- and NS3-treated immature DCs, but not in DCs of HCV patients, was reversed by LPS maturation, suggesting more complex DC defects in vivo than those mediated by core or NS3 proteins. Our results reveal that HCV core and NS3 proteins activate monocytes and inhibit DC differentiation in the absence of the intact virus and mediate some of the immunoinhibitory effects of HCV via IL-10 induction.
Food Insecurity, Poverty, Unemployment and Obesity in the United States: Effect of (Not) Considering Back-Door Paths in Policy Modeling

The causes and consequences of food environment factors such as food insecurity, poverty, unemployment and obesity in the United States are complex. Once causality patterns with regards to these variables are identified, it is important to recognize front-door (Pearl, 2000) and back-door paths (Pearl, 2000) associated with these variables to make sensible and credible policy decisions. These policy interventions are known as performing do-Calculus (Pearl 2000, Spirtes et al., 2000) in causality literature. In this study we use the complex interactions of four food environment variables in the United States (food insecurity, poverty, unemployment and obesity) estimated using artificial intelligence and directed acyclic graphs by Dharmasena, Bessler and Capps (2016) and perform several policy interventions, recognizing front-door and back-door paths. Such policy simulations are vital for agencies not only to design appropriate policies for food assistance, poverty alleviation, combating food insecurity and obesity, but also to recognize effects of policy prior to the desired intervention. Preliminary analysis shows that there are two front-door paths from income to food insecurity, via poverty and via unemployment. Also, there is a front-door path from poverty to food insecurity, while there is an important back- door path from poverty to food insecurity via unemployment.
Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth*

Peutz-Jeghers syndrome is an inherited cancer syndrome that results in a greatly increased risk of developing tumors in those affected. The causative gene is a protein kinase termed LKB1, predicted to function as a tumor suppressor. The mechanism by which LKB1 is regulated in cells is not known. Here, we demonstrate that stimulation of Rat-2 or embryonic stem cells with activators of ERK1/2 or of cAMP-dependent protein kinase induced phosphorylation of endogenously expressed LKB1 at Ser431. We present pharmacological and genetic evidence that p90RSK mediated this phosphorylation in response to agonists that activate ERK1/2 and that cAMP-dependent protein kinase mediated this phosphorylation in response to agonists that activate adenylate cyclase. Ser431 of LKB1 lies adjacent to a putative prenylation motif, and we demonstrate that full-length LKB1 expressed in 293 cells was prenylated by addition of a farnesyl group to Cys433. Our data suggest that phosphorylation of LKB1 at Ser431 does not affect farnesylation and that farnesylation does not affect phosphorylation at Ser431. Phosphorylation of LKB1 at Ser431 did not alter the activity of LKB1 to phosphorylate itself or the tumor suppressor protein p53 or alter the amount of LKB1 associated with cell membranes. The reintroduction of wild-type LKB1 into a cancer cell line that lacks LKB1 suppressed growth, but mutants of LKB1 in which Ser431 was mutated to Ala to prevent phosphorylation of LKB1 were ineffective in inhibiting growth. In contrast, a mutant of LKB1 that cannot be prenylated was still able to suppress the growth of cells.
Long-term results of coronary artery bypass surgery in patients with severely depressed left ventricular function.

STUDY OBJECTIVE The objective of the present study was to evaluate medium- and long-term results of coronary artery bypass grafting (CABG) in patients with severe left ventricular dysfunction (LVD). DESIGN Prospective evaluation (clinical follow-up and equilibrium radionuclide angiography scan) of all the patients with severe LVD who underwent CABG from November 1986 to November 1991 at the Tel Aviv Medical Center and were referred to the Post Cardiac Surgery Follow-up Clinic at this institution. PATIENTS Seventy-four consecutive patients (65 men, 9 women, aged 43 to 82 years; mean age, 68.2 years) with left ventricular ejection fraction (LVEF) of 30% or less who underwent isolated CABG (without automatic implantable cardioverter-defibrillator implantation, aneurysmectomy, valve replacement, or other open heart procedures) during a 5-year period and were discharged from hospitalization were prospectively evaluated. Preoperatively, 62% of patients had angina, 65% had congestive heart failure (CHF), and the LVEF ranged from 10 to 30%. The mean number of grafts was 2.98 per patient; the internal mammary artery (IMA) was used in 54 patients. The patients were followed up 4 to 96 months (mean, 64.9 months) post-surgery for survival, clinical status, and left ventricular function. RESULTS Survival was 96%, 93.2%, 91.9%, 87.8%, 86.5%, 83.8%, and 83.8%, at 1, 2, 3, 4, 5, 6, and 7 years, respectively. Postoperatively, mean angina class improved from 2.9 to 1.4 (p < 0.0001) and mean CHF class improved from 2.7 to 1.8 (p < 0.0001). Mean LVEF improved from 23.5% preoperatively to 35.7% postoperatively (p < 0.0001). CONCLUSIONS The following occur in patients with coronary artery disease and severe LVD undergoing CABG: (1) good medium- and long-term survival is attained; (2) angina class improves; (3) CHF class improves; (4) LVEF objectively improves; and (5). IMA can be used safely as a conduit.
Grid interactive solar PV based water pumping using BLDC motor drive

This paper proposes a bidirectional power flow control of a grid interactive solar photovoltaic (SPV) fed water pumping system. A brushless DC (BLDC) motor-drive without phase current sensor, is used to run a water pump. This system and control enable a consumer to operate the water pump at its full capacity for 24-hours regardless of the climatic condition and to feed a single phase utility grid when the water pumping is not required. The full utilization of SPV array and motor-pump is made possible in addition to an enhanced reliability of the pumping system. Using a single phase voltage source converter (VSC), a unit vector template (UVT) generation technique accomplishes a bidirectional power flow control between the grid and the DC bus of voltage source inverter (VSI) which feeds a BLDC motor. The VSI is operated with fundamental frequency pulses which minimizes the switching loss. The maximum power point (MPP) operation of SPV array, and power quality standards such as power factor and total harmonic distortion (THD) of grid are met by this system. Its applicability and reliability are demonstrated by various simulated results using MATLAB/Simulink platform and hardware implementation.
MC-CDMA performance analysis for different spreading codes at HPA Saleh model

Multi-carrier code division multiple access (MC- CDMA) is a powerfull modulation technique that is being considered in many emerging broadband communication systems. However the high peak to average power ratio (PAPR) of the MC-CDMA signal, a special drawback of multicarrier transmission, has limited its wider aplication due to inefficient use of power amplifiers. PAPR strongly depends on particular spreading sequences considered for transmission. Therefore, the performance analysis of uplink MC-CDMA for different spreading sequences and for different receivers in the presence of Saleh model of high power amplifier (HPA) is presented. The results of our analysies show that the aplication of Golay codes in conduction with micro statistic multi-user receiver (MSF-MUD) provide significant better result as the other investigated spreading sequences and receivers.
[Planning and activities of daily living in Alzheimer's disease and frontotemporal dementia].

OBJECTIVE To study the relationship between the disturbances in activities of daily living and the scores on tests assessing planning activities in frontotemporal dementia (FTD) and Alzheimer's disease (AD). METHODS Eleven patients with FTD were compared to 11 patients with AD and 29 healthy controls. Cognitive status, evaluated by the Dementia Rating Scale (DRS) and the Mini Mental State Examination (MMSE) was identical in the two groups of patients. Activities of daily living were assessed by three questionnaires completed by the main caregiver: (1) the Cognitive Difficulties Scale (CDS); (2) the NADL, a composite scale including the Physical self-maintenance scale (ADL) the Instrumental activities of daily living (IADL) the social activities scale, (SADL); (3) the Dysexecutive Questionnaire (DEX) from the Behavioural Assessment of the Dysexecutive Syndrome. Planning abilities were assessed by the tower of London and three tests from the BADS: the key search, the zoo map and the six elements. RESULTS No quantitative differences were found between FTD and AD patients in daily living activities disturbances or scores on planning tests. Both were closely related to the global cognitive performance assessed by the DRS or the MMSE but no clear relationship was found between them. The scores on the tower of London were not correlated to those on the tests from the BADS. CONCLUSION Neither assessment of activities of daily living or scores on the planning tests could differentiate FTD from AD. Planning appears as a multidimensional construct poorly assessed by the usual assessment tools.
An update on microRNAs as colorectal cancer biomarkers: where are we and what’s next?

miRNAs are abundant classes of small, endogenous non-coding RNAs, which inhibit the expression of target gene via post-transcriptional regulation. In addition to an important functional role miRNAs play in carcinogenesis, emerging evidence has demonstrated their feasibility as robust cancer biomarkers. In particular, the recent discovery of miRNAs in the body fluids provides an attractive opportunity for the development of non-invasive biomarkers for the diagnosis, prognosis and predictive response to cancer therapy. Colorectal cancer (CRC) is one of the most common cancers worldwide, and accumulating data provides a compelling case for the potential exploitation of miRNAs as CRC-biomarkers. This review summarizes the current state of literature in the field, focusing on the clinical relevance of miRNAs as potential biomarkers for CRC treatment and discussing the forthcoming challenges to further advance this exciting field of ‘academic research’ into ‘bedside clinical care’ of patients suffering from CRC.
Proliferation index as a prognostic marker in breast cancer

Background. The proliferative activity of tumors has been extensively investigated with different approaches, among which the use of the monoclonal antibody Ki‐67 represents an easy and reliable means of assessing cell proliferation. In this study, the proliferative activity of 129 primary breast cancers was investigated, and the results were related to prognosis.
Resolution of cellular compartments involved in membrane potential changes accompanying IgE‐mediated degranulation of rat basophilic leukemia cells.

The overall membrane potential of rat basophilic leukemia cells (RBL‐2H3) calculated from the transmembrane distribution of the lipophilic, tritium‐labelled cation tetraphenyl‐phosphonium [(3H]TPP+) was resolved into its mitochondrial and plasma membrane potential components. Using the mitochondrial uncoupler carbonylcyanide‐p‐trifluormethoxyphenyl hydrazone (FCCP) which collapses the mitochondrial potential, it was shown that about one third of the overall potential resulted from the mitochondrial contribution. Degranulation of the RBL cells induced by two different IgE‐cross‐linking agents (specific antigen and anti‐IgE antibodies), was accompanied by, and well correlated with, a decrease in the overall potential. However, evaluation of the source of these observed potential changes revealed that the FCCP‐insensitive fraction of the overall potential, delta psi P, (representing the plasma membrane potential), was not affected. In contrast, the FCCP‐sensitive component due to the mitochondrial potential decreased when receptor cross‐linking increased. Thus, the observed decrease in the overall potential is most probably a secondary event in the sequence leading from stimulus to secretion. Indeed, exposure of the RBL cells either to a high external concentration of K+ ions or to a high amount of external TPP+, both causing depolarization, failed to trigger degranulation. It is suggested that the apparent decrease in the measured overall potential is a reflection of the mitochondrial membrane depolarization. The latter is most probably caused by mitochondrial Ca2+ uptake initiated by the increase in the intracellular concentration of Ca2+ which follows cells activation.
Assessing Soil Metal Levels in an Industrial Environment of Northwestern China and the Phytoremediation Potential of Its Native Plants

Various industrial activities contribute heavy metals to terrestrial ecosystems. In order to evaluate the soil quality of industrial areas and to identify the potential phytoremediator from the native plant species, we collected 45 surface soil samples and 21 plant species in a typical industrial area of northwestern China. The results showed that the average values of the Cd, Cr, As, Pb, Cu, and Zn in the soils were 36.91, 1.67, 7.20, 1.38, 1.27, and 6.66 times, respectively, compared with the corresponding background values. The average single factor pollution index for heavy metals decreased in the order of Cd > As > Zn > Cr > Cu > Pb. The study area was seriously polluted by Cd and As, slightly polluted by Zn, and had relatively little contamination by Cr, Pb, and Cu. In terms of the average Nemerow synthetic pollution index in every sampling site, 97.78% of the samples were seriously polluted and 2.22% of the samples were moderately polluted, which indicated that almost all of the samples in the industrial area were seriously polluted. The results of the biomass, heavy metal concentrations, bioconcentration factors (BCF), and translocation factors (TF) for the native plants showed that Achnatherum splendens for metal Cr presented a phytostabilization potential, Artemisia scoparia and Echinochloa crusgalli for metal Cu and Halogeton arachnoideus for metal Zn presented a phytoextraction potential, and all of the studied plants were limited as phytoremediators for Cd or Pb contaminated soil.
conceptual framework to understand language teacher identities

Language teacher identity (LTI) has recently become a prominent theme in the second language teacher education (SLTE) research because teacher identities play a major role in teachers’ learning-to-teach processes and instructional practices. Teacher identity refers to teachers’ dynamic self-conception and imagination of themselves as teachers, which shifts as they participate in varying communities, interact with other individuals, and position themselves (and are positioned by others) in social contexts. Therefore, it casts an influence upon a wide array of matters, ranging from how language teachers learn to perform their profession, how they practice theory and theorize their practice, how they educate their students, and how they interact and collaborate with their colleagues in their social setting. This paper offers a conceptual framework for LTI that explicates the interrelationships between teacher identity and these core constructs: teacher learning, teacher cognition, teachers’ participation in communities of practice, contextual factors, teacher biographies, and teacher emotions.
The dual role of auditor-provided tax services (ATS) in SMEs tax planning

The aim of this study is to examine the role of auditor-provided tax services (ATS) in Small Medium Enterprises' (SMEs') tax planning. Tax planning is proxies by effective tax rate (ETR) measured as tax expenses divide by profit before tax. The main objectives of this study are to examine the influence of auditor-provided tax services fees and auditor size towards tax planning in Malaysian SMEs. To achieve the objective, this study used a pooled sample data of 319 SMEs from the years 2000 to 2010. This study found that auditor-provided tax services fees (ATSFEE) paid to the auditor can reduce the level of taxable income among SMEs. The findings also suggest that the size of auditor (Big-4 and non-Big 4) does influence the level of SMEs' taxable income and provided the evidence that SMEs companies are engaged in tax planning activities. This study found that other firm's characteristics such as leverage, capital intensity and profitability can influence the level of taxable income among SMEs. This study is a contribution to the pool of literature regarding the behavior of auditors that audit SMEs even as they provide other services. These findings can also assist the Malaysian government to amend the existing acts or introduce new policies for Malaysian SMEs.