Miracle-dz/UniFAR-FTUs huggingface dataset:
Estudio de la reparación de las lesiones del manguito rotador mediante compuestos transportador-BMP

Las roturas del manguito rotador afectan aproximadamente al 30% de la poblacion mayor de 60 anos. Aunque algunos estudios abogan por el tratamiento conservador de las roturas completas, el tratamiento mas empleado es la reparacion quirurgica. Sin embargo, a pesar de los buenos resultados clinicos y de los avances tecnicos que incrementan la fortaleza mecanica de la sutura, se recogen porcentajes de rerrotura tras su reparacion que oscilan entre un 16% y un 94% segun las series. Este hecho nos lleva a buscar otro tipo de estrategias biologicas destinadas a mejorar dicha reparacion. El empleo de transportadores que vehiculicen factores de crecimiento es uno de los pilares en los procesos de ingenieria titular. La familia de las Proteinas Morfogeneticas Oseas (BMP) son los factores de crecimiento con capacidades osteoinductivas mas potentes y hay varios estudios que sugieren beneficios de estos en el tratamiento de las lesiones del manguito rotador mejorando las propiedades biomecanicas y favoreciendo la diferenciacion tendinosa. Asi mismo, son muchos los biomateriales que se han probado con la finalidad de promover la reparacion de las lesiones, incrementar la fortaleza mecanica de la sutura y actuar como transportadores de factores de crecimiento y/o celulas.
A Longitudinal Investigation into Excess Risk for Blood-Borne Infection Among Young Injection Drug Users (IUDs)

Studies have found that young injection drug users (IDUs) may be at elevated risk for blood-borne infection transmission, however few studies have evaluated risk longitudinally. We compared variables between younger (≥ 29 years) and older (≤ 30 years) IDUs in Vancouver, British Columbia, Canada between 1996 and 2006. Of 1598 participants, 582 (36%) were aged ≤ 29 years. In prospective analyses (N = 1598), factors associated with younger age included: borrowing syringes, and frequent (≥ 1 daily) injection of heroin, cocaine, and speedballs. Additionally, younger IDUs were less likely to access drug treatment or methadone maintenance therapy (MMT) and test HIV and HCV-positive. Younger IDUs have lower HIV and HCV prevalence, but a higher risk profile and lower uptake of drug treatment. These factors underscore the need to target this age group and develop youth friendly interventions to minimize drug-related harms.
Diseño e implantación de un circuito electrónico para la adquisición de señales de electromiografía superficial en músculos de miembros superiores

Este trabajo de investigacion propone el diseno e implementacion de un circuito electronico que permita realizar registros de senales de electromiografia superficial en miembros superiores. En este diseno se contemplan diversos factores, como las afectaciones externas a la senal tomada, debido al ruido blanco (Garcia Pinzon y Mendoza, 2014), el calentamiento de los elementos electronicos usados y el estado fisico del paciente; por esto se establecio un protocolo para la toma de datos con el fin de que los registros tengan las mismas condiciones, y obtener asi unas senales de EMG mas confiables. Para la toma de registros se usaron distintos pacientes; cada uno hizo la prueba sentado y con el brazo al aire. Los registros de cada paciente son diferentes, ya que el movimiento de pronacion genera un pico mas amplio que el de supinacion y las senales se visualizaban con ayuda de un osciloscopio con el cual se podia medir la frecuencia y la amplitud de cada una de las senales.
Coding a terminated bus for low power

Coding was proposed as a general method of decreasing power dissipation for the I/O. Lower power dissipation can be obtained by using extra bus liner for coding the data. This paper presents an application of the general theory of limited-weight codes for a class of parallel terminated buses with pull-up terminators (e.g. Rambus). Power dissipation on such a bus-line is larger for a logical 1 and it follows that patterns with few 1s should be chosen. A perfect k/2-limited weight code equivalent to the previously proposed Bus-Invert method and a novel non-perfect 3-limited weight code are described. Both codes can be algorithmically generated and practical issues related to their implementation on the Rambus are discussed.
HER2 polymorphism and breast cancer risk in Portugal

Breast cancer is a major public health problem around the world, and its carcinogenesis is not yet well understood. The human epidermal growth factor Receptor 2 (HER2) seems to play an important role in the development of this neoplasia, and genetic alterations in this gene, such as point mutations and polymorphisms have been detected in breast cancer patients. We analysed the frequency of a single nucleotide polymorphism in the HER2 gene in blood samples from 152 breast cancer patients and 146 healthy controls using the polymerase chain reaction methodology, followed by restriction fragment length polymorphism (PCR-RFLP). We found a twofold increase in risk of breast cancer in women who are carriers of a Val allele genotype–Ile/Val and Val/Val genotypes [odds ratio (OR)=2.00; 95% confidence interval (CI) 1.23–3.25; P=0.005]. Our results indicate an association between the presence of the Val allele in the HER2 polymorphism and the risk of breast cancer. Further studies are needed to evaluate the role of this polymorphism in the behaviour of breast cancer.
Acute bacterial meningitis in adults: Predictors of outcome

Case fatality ratio and permanent sequelae of acute bacterial meningitis remain high in recent decades. A prospective longitudinal study of adult patients admitted with community acquired acute bacterial meningitis at a tertiary infectious diseases unit aimed to identify predictors of unfavourable outcome – death and sequelae. Anamnestic, clinical and laboratory data and clinical outcome were recorded. From 1997 to 2006, 279 adults (122F, 157M) with a median age of 51 y were admitted with acute bacterial meningitis. Predisposing condition and comorbidity were recorded in 42% and 38% of patients, respectively. Time between symptoms onset and antibiotic treatment ranged from 6 to 160 h. An aetiological agent was identified in 77% of patients: Streptococcus pneumoniae (29%) and Neisseria meningitidis (27%) were the most frequent. 55 patients (20%) died and 63 (23%) had neurological sequelae 6 months after discharge. In multivariate analysis, 7 independent predictors of unfavourable outcome were identified: internal comorbidity, time to treatment >48 h, coma, hypotension, high CSF protein, low glucose ratio, and non-meningococcal aetiology. The results suggest that acute bacterial meningitis remains associated with significant morbidity and mortality. Maintaining a high clinical suspicion and initiating appropriate diagnostic testing and therapeutic interventions promptly are essential for an optimal clinical outcome.
Autophagy activation involved in hypoxic‐ischemic brain injury induces cognitive and memory impairment in neonatal rats

Hypoxic‐ischemic brain injury (HIBI) in neonates can lead to lifelong cognitive and memory impairment, but protective strategies are lacking at present. It has been demonstrated that autophagy plays a critical role in HIBI, while the function of autophagy in cognitive and memory impairment induced by HIBI in neonates has not been tested. In this study, we tested the impact of autophagy on the impairment of cognitive function and memory in HIBI neonatal rats by using a Morris water maze and investigated its possible mechanisms, which were established as HIBI model by ligating the left common carotid artery in neonatal rats, followed by 2‐h hypoxia. The expression of microtubule‐associated protein 1 light chain 3 (LC3)‐II increased in HI group 24 h after HI in neonatal rats, while Sequestosome 1 (P62/SQSTM1), phosphorylated cAMP‐response element‐binding protein (p‐CREB) decreased (compared with the sham group, p < 0.05), which were shown in the same left hippocampus CA3 region by immunofluorescence analysis. Brain injury of neonatal rats was aggravated significantly at 7 day after HI, coinciding with the results of Morris water maze. An autophagy inhibitor, 3‐methyladenine (3‐MA) pretreatment significantly attenuated the increase of LC3II and the loss of P62/SQSTM1 and p‐CREB, ameliorated neuronal death, and improved the results of Morris water maze. Our results demonstrate that HIBI in neonatal rats induced excessive autophagy flux, which aggravated brain injury and induced cognitive and memory impairment during adolescence. Inhibition of autophagy reversed the results partly and improved the function of spatial learning and memory by attenuating the reduction of p‐CREB. The use of autophagy modulators in the immature brain would create new opportunities for protective strategies clinically in the future.
Underestimation of risk by Gail model extends beyond women with atypical hyperplasia.

REFERENCES 1. Meyerhardt JA, Niedzwiecki D, Hollis D, et al: Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: Findings from Cancer and Leukemia Group B 89803. J Clin Oncol 26:4109-4115, 2008 2. Meyerhardt JA, Tepper JE, Niedzwiecki D, et al: Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: Findings from Intergroup Trial 0114. J Clin Oncol 22:648-657, 2004 3. Dignam JJ, Polite BN, Yothers G, et al: Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. J Natl Cancer Inst 98:1647-1654, 2006 4. Meyerhardt JA, Catalano PJ, Haller DG, et al: Influence of body mass index on outcomes and treatment-related toxicity in patients with colon carcinoma. Cancer 98:484-495, 2003 5. Ananda S, Field KM, Kosmider S, et al: Patient age and comorbidity are major determinants of adjuvant chemotherapy use for stage III colon cancer in routine clinical practice. J Clin Oncol 26:4516-4517, 2008; author reply 4517-4518 6. Lyman G: Undertreatment of cancer patients with chemotherapy is a global concern. J Oncol Pract 4:114-115, 2008 7. Meyerhardt JA, Catalano PJ, Haller DG, et al: Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol 21:433-440, 2003
RF design options for a 180 mev H- linac for megawatt beam facilities

Future projects like a neutrino factory or an advanced spallation neutron source require high power proton accelerators capable of producing beams in the multi-MW range. The quality of the beam delivered to the target is very much dictated by the accelerator front end and by the lower energy linac. Prompted by the front end test stand (FETS) under construction at RAL, a new 180 MeV FT linac is being considered as a possible replacement for the aging current 70 MeV ISIS injector, and the same linac has also been included in designs for the proton driver for a possible UK neutrino factory. In this paper, different RF design options are analysed and a general layout for the new linac is presented based on two accelerating structures to raise the beam energy from 3 to 180 MeV: a 324 MHz drift tube linac (DTL), making use of commercial Toshiba klystrons, followed by side coupled linac (SCL) with a triple frequency jump at the transition between the two structures.
A Novel Kinase Inhibitor, INCB28060, Blocks c-MET–Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3

Purpose: The c-MET receptor tyrosine kinase plays important roles in the formation, progression, and dissemination of human cancer and presents an attractive therapeutic target. This study describes the preclinical characterization of INCB28060, a novel inhibitor of c-MET kinase. Experimental Design: Studies were conducted using a series of in vitro and in vivo biochemical and biological experiments. Results: INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET–dependent tumor cell lines. As a result, INCB28060 potently inhibits c-MET–dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro. Oral dosing of INCB28060 results in time- and dose-dependent inhibition of c-MET phosphorylation and tumor growth in c-MET–driven mouse tumor models, and the inhibitor is well tolerated at doses that achieve complete tumor inhibition. In a further exploration of potential interactions between c-MET and other signaling pathways, we found that activated c-MET positively regulates the activity of epidermal growth factor receptors (EGFR) and HER-3, as well as expression of their ligands. These effects are reversed with INCB28060 treatment. Finally, we confirmed that circulating hepatocyte growth factor levels are significantly elevated in patients with various cancers. Conclusions: Activated c-MET has pleiotropic effects on multiple cancer-promoting signaling pathways and may play a critical role in driving tumor cell growth and survival. INCB28060 is a potent and selective c-MET kinase inhibitor that may have therapeutic potential in cancer treatment. Clin Cancer Res; 17(22); 7127–38. ©2011 AACR.
Amélioration des connaissances sur les épidémies d’arboviroses en Nouvelle-Calédonie et dans la région Pacifique : importance du vecteur régional Aedes aegypti.

Depuis la fin du 19eme siecle, les epidemies dues aux arbovirus constituent un probleme de sante publique majeur en Nouvelle-Caledonie et dans la region Pacifique. Ces cinq dernieres annees, la frequence des epidemies de dengue a augmente et l’introduction des virus du chikungunya et du Zika (ZIKAV) a demontre que cette region du monde pouvait etre un hot spot d’emergence des arboviroses. Ces trois virus sont transmis par des moustiques du genre Aedes dont le principal vecteur de la region Pacifique est Aedes aegypti. Mis a part des donnees sur l’epidemiologie de la dengue dans la region, peu d’informations etaient alors disponibles sur les vecteurs ou sur leurs capacites a transmettre les arbovirus. Or ces donnees sont cruciales pour mieux comprendre l’incidence particuliere de ces epidemies dans la region.Dans ce travail de these, nous avons tout d’abord caracterise genetiquement le vecteur Ae. aegypti de la region Pacifique et montre une difference genetique moderee de ce vecteur a l’echelle regionale. Nous avons ensuite, pour la premiere fois, evalue la competence vectorielle d’Ae. aegypti pour les virus de la dengue 1 (DENV-1) et du ZIKAV. Les resultats obtenus montrent une faible transmission du DENV-1 et des taux de transmission heterogenes du ZIKAV en fonction des differentes lignees virales.Les interactions entre le genotype du vecteur et le genotype viral semblent donc revetir une importance particuliere dans notre contexte. Les resultats obtenus au cours de ce travail doctoral devraient permettre une meilleure evaluation du risque de survenue d’une epidemie d’arbovirose en Nouvelle-Caledonie.
Occupational Therapy in Venezuela

We hear much of the wealth and expansion programmes of some of the South American countries. Venezuela is at present a leader in this respect and it is of interest to know that the needs for better educated and more healthful citizens are being considered. For the latter, clinics and hospitals are being extended in many centres throughout the country. And so on October 9th, 1954 the Venezuelan Institute of Social Security celebrated its tenth anniversary with the inauguration of new facilities. The First Lady, Seriora Flor de Pérez Jiménez, accompanied by the wives of the Cabinet Ministers and other high officials dedicated a Physical Therapy and Rehabilitation Centre for disabled workers, at La Guaira. This Centre was established in cooperation with the Technical Assistance Programme of the United Nations—a programme which is intended to promote the economic and social progress and development of peoples. Dr. Alejandro Rhode has been associated with the Venezuelan Institute of Social Security for the past ten years and during this time he has become interested in rehabilitation. When investigating Workmen's Compensation procedures in the United States he found that rehabilitation centres were playing an important role in the handling of industrial accidents. As a result of his interest, in the spring of 1953 Dr. Rhode was sent to New York to make official enquiries regarding help from United Nations for the establishment of rehabilitation facilities in his own country. In the fall of 1953 Dr. Gustave Gingras, as Consultant in Rehabilitation for the United Nations Technical Assistance Administration visited Venezuela to investigate the wisdom of such a programme. On the basis of the favourable report of Dr. Gingras a Canadian team of two Physiotherapists and one Occupational Therapist was sent to Venezuela in the spring of 1954 to help organize the programme. The basic equipment and materials for the Centre had been ordered from Canada and the United States several months previous to our arrival. Failing early delivery of these we were able to spend two months in Caracas orientating ourselves with the city, the language and the customs of the country. Caracas, the capital with a population nearing the million mark is a fascinating city. It lies in a long valley in the foothills of the Andes at a height of 3000 ft. above the sea and but twenty minutes from its port town of La Guaira. Much of colonial Caracas with its narrow cobblestone streets, its houses with heavydoored exteriors and bright, patio-lit interiors has in the past ten years been changing to a city of neon signs, elevator apartments, thirty-five storied sky-
GENETIC VARIATION AMONG TYPHA POPULATIONS OF THE SOUTHEASTERN UNITED STATES

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Falls and Injuries in Frail and Vigorous Community Elderly Persons

Identification of different types of falls and fallers among elderly persons might aid in the targeting of preventive efforts. In a representative sample of 336 community elderly, subjects were assigned to Frail, Vigorous, or Transition groups based on observed patterns of clustering among demographic, physical, and psychological variables. The frequency and circumstances of falls in these three groups were then ascertained. As expected, the observed incidence of falling in one year of follow‐up was highest in the Frail group (52%) and lowest in the Vigorous group (17%). However, 22% (5/23) of falls by vigorous subjects, but only 6% (5/89) of falls by frail subjects, resulted in a serious injury. Compared with frail subjects, vigorous fallers were somewhat more likely to fall during displacing activity (53% vs 31%), with an environmental hazard present (53% vs 29%), and on stairs (27% vs 6%). These findings suggest that fall‐related injuries can be a serious health problem for vigorous as well as frail elderly persons. Injury prevention, therefore, should be directed at all elderly persons but tailored to expected differences in fall circumstances.
Spontaneous and Induced Mutation in Mycobacterium avium

Mycobacterium avium exhibits two colonial forms, transparent and opaque, on 7H10 agar. The transparent variant of M. avium B2900 undergoes a spontaneous transition to the opaque form at the rate of 4.7 × 10−5 to 3.5 × 10−4 per cell per generation. The two variants differ in cell morphology and mass; the opaque cells are two to three times as large as the transparent in terms of dry weight, total protein, deoxyribonucleic acid, or carbohydrate. A search for auxotrophic mutants resulted in the induction, by nitrosoguanidine or ultraviolet irradiation, of conditional, salt-sensitive mutants. One such mutant requires methionine and tryptophan supplementation for growth in a medium containing a buffer at high molarity. The clinical and physiological significance of these findings is discussed.
A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10LacZ allele

To study the expression/function of Tbx10, a T‐box gene, Tbx10LacZ/+ mice were established by replacing the T‐box coding region with a LacZ gene. X‐gal staining showed that LacZ+ cells were localized to two‐cell populations in rhombomere 4 and rhombomere 6. No significant differences in the locations of LacZ+ cells were found between Tbx10LacZ/+ and Tbx10LacZ/LacZ mice, and the Tbx10LacZ/LacZ mice were viable and fertile. We found that the LacZ+ cells are present in both embryonic and adult mice. Histological studies suggest that the rhombomere 4‐derived LacZ+ cells are a subpopulation of the ventral interneurons in the pons. genesis, 48:295–302, 2010. © 2010 Wiley‐Liss, Inc.