Miracle-dz/UniFAR-FTUs huggingface dataset:
REDUCING REGIONAL DISPARITIES IN THE IMPACT OF DEVELOPING CLUSTERS

The issue of regional development aimed to reducing regional disparities is a current topic in the whole of the European Union. Socio-economic analysis of the region is starting activity in determining the development strategy of the region. In the analysis of regional development will use a variety of concepts and methods. Regional development concepts are always confronted with convergence or divergence. The main aim of this paper is to access the level of regional disparities in the Slovak Republic with a focus on the role of cluster in regional development. The analysis is carried out using the beta and sigma convergence of statistical data classified in the cross-sectional structure
Decentralized control of discrete large scale interconnected systems

In this paper we study the decentralized stabilization problem of linear discrete large scale interconnected systems. The design is based on stability result that employs the notion of block diagonal dominance in matrices and improves upon the existing result for this problem. Our main result is the sufficient condition for discrete decentralized stabilization. Anew and simple algorithm is proposed.
Biochemical Engineering Analysis of Critical Process Factors in the Biomass‐to‐Ethanol Technology

Ethanol from cellulosic biomass is a promising renewable liquid transportation fuel. Applied research in the area of biomass conversion to ethanol in the last 20 years has answered most of the major challenges on the road to commercialization but, as with any new technology, there is still room for performance improvement. A verified mathematical model was used to examine the most critical biochemical engineering aspects of ethanol production in this study. Extensive simulations of the simultaneous saccharification and fermentation (SSF) of cellulose were conducted to identify the effects of operating conditions, pretreatment effectiveness, microorganism parameters, and enzyme characteristics on ethanol production. The results clearly show that the biomass−enzyme interaction plays a dominant role in determining the performance of SSF in batch and continuous operating modes. In particular, the digestibility of the substrate (as a result of pretreatment) and the cellulase enzyme dosage, specific activity, and composition had a profound effect on ethanol yield. This investigation verified the conclusion that R&D emphasis should be placed on developing more effective pretreatment methods and producing cellulase preparations of high specific activity (low cost per enzyme unit) to realize gains from any development of advanced hexose/pentose‐fermenting organisms.
Probiotics-host communication

The intestinal microbiota includes a diverse group of functional microorganisms, including candidate probiotics or viable microorganisms that benefit the host. Beneficial effects of probiotics include enhancing intestinal epithelial cell function, protecting against physiologic stress, modulating cytokine secretion profiles, influencing T lymphocyte populations, and enhancing antibody secretion. Probiotics have demonstrated significant potential as therapeutic options for a variety of diseases, but the mechanisms responsible for these effects remain to be fully elucidated. Accumulating evidence demonstrates that probiotics communicate with the host by modulating key signaling pathways, such as NF-κB and MAPK, to either enhance or suppress activation and influence downstream pathways. Beneficial microbes can profoundly alter the physiology of the gastrointestinal tract, and understanding these mechanisms may result in new diagnostic and therapeutic strategies.
Pengaruh Dana Pihak Ketiga (DPK), Capital Adequacy Ratio (CAR), dan Non Performing Financing (NPF) terhadap Profitabilitas Bank Syariah dengan Pembiayaan sebagai Variabel Intervening

The aim of this resesearch is to identify and analyze the determinant of Profitability in sharia banking of Indonesia in the period of 2011-2015. Profitability is dependent variabel in this research. There are three independent variables that used, wich are Third Party Funds, Capital Adequacy Ratio, Non Performing Financing, and an intervening variabel which is Financing. Sampling technique used is pruposive sampling, obtained by amount 5 sharia banking for sample from 11 syariah banking in Indonesia period 2011-2015. The data analyzed with path analysis using SPSS program. The result of this research show that Non Performing Financing (NPF) and Capital Adequacy Ratio (CAR) has negative influance significant to financing, Third Party Funds have positive influance and not significant to financing. Third Party Funds and Financing has positive influance significant to Profitability, Non Performing Financing (NPF) have negative influance significant to profitability, and then Capital Adequacy Ratio (CAR) have negative influance not significant to Profitability. But, Financing can not mediate influance beetwen variable independent Third Party Financing, Capital Adequacy Ratio (CAR), and Non Performing Financing (NPF) to Profitability.
Molecular Characterization of the Gene Encoding a New AmpC β-Lactamase in a Clinical Strain of Acinetobacter Genomic Species 3

ABSTRACT A presumptive chromosomal cephalosporinase (pI, 9.0) from a clinical strain of Acinetobacter genomic species 3 (AG3) is reported. The nucleotide sequence of this β-lactamase shows for the first time the gene encoding an AmpC enzyme in AG3. In addition, the biochemical properties of the novel AG3 AmpC β-lactamase are reported
pengujian holiday effect terhadap abnormalreturn dan trading volume activitydi bursa efek indonesia

the capital market in indonesia is currently growing steadily, given the increasing public awareness about the importance of investing. the purpose of the investor to invest in the capital market is to get maximum profit. every investor has a character in trading on the exchange, and some investor have the same behavior with each other. holiday effects become one of the phenomenon in which investors do buying and selling action before and after holiday. this is indicated by the difference of abnormal return and trading volume activity before and after the holiday. some factors can be the cause of investors taking decisions before and after the holidays, among which information circulating and investor psychological factors. this study examines whether there are differences in abnormal return and trading volume activity before and after holidays such as lunar new year, idul fitri and christmas. the consideration of choosing the three holidays is predicted by higher public interest on the holiday. tests on this study using non-parametric statistical test wilcoxon signed. the results of this test are, 1) no difference of abnormal return before and after lunar new year and there is difference of trading volume activity before and after lunar new year, 2) no difference abnormal return and trading volume activity before and after idul fitri, 3) no difference abnormal return before and after christmas and there is a difference in trading volume activity before and after christmas.
Emotional contagion with virtual characters

In social psychology, emotional contagion describes the widely observed phenomenon of one person's emotions mimicking surrounding people's emotions [8]. While it has been observed in humanhuman interactions, no known studies have examined its existence in agent-human interactions. As virtual characters make their way into high-risk, high-impact applications such as psychotherapy and military training with increasing frequency, the emotional impact of the agents' expressions must be accurately understood to avoid undesirable repercussions.
Supporting Group Brainstorming

Previous Work: A brainstorming system is distinguished from computer-aided design and project management tools, which are tailored for design execution. Instead, we seek to assist the early, conceptual phase of problem-solving, when many alternatives are considered. Electronic brainstorming systems have been used successfully (Gallupe and Cooper, 1993; Neveitt, 2000). We seek to extend these approaches by (1) focusing specifically on collaborative (as opposed to private) brainstorming, (2) enabling users to express their ideas with natural modalities, and (3) developing a system that “thinks off-line” about the ideas it captures. Approach: Our approach is first to understand how people brainstorm effectively without computer support. To do this, we will collect and distill the principles used by professional brainstorming facilitators, then develop a system tailored to assist the process, using technologies like the following:
Effects of a school-based intervention for urban adolescents with asthma. A controlled trial.

RATIONALE Asthma prevalence and morbidity are especially elevated in adolescents, yet few interventions target this population. OBJECTIVES To test the efficacy of Asthma Self-Management for Adolescents (ASMA), a school-based intervention for adolescents and medical providers. METHODS Three hundred forty-five primarily Latino/a (46%) and African American (31%) high school students (mean age = 15.1 yr; 70% female) reporting an asthma diagnosis, symptoms of moderate to severe persistent asthma, and asthma medication use in the last 12 months were randomized to ASMA, an 8-week school-based intervention, or a wait-list control group. They were followed for 12 months. MEASUREMENTS AND MAIN RESULTS Students completed bimonthly assessments. Baseline, 6-month, and 12-month assessments were comprehensive; the others assessed interim health outcomes and urgent health care use. Primary outcomes were asthma self-management, symptom frequency, and quality of life (QOL); secondary outcomes were asthma medical management, school absences, days with activity limitations, and urgent health care use. Relative to control subjects, ASMA students reported significantly: more confidence to manage their asthma; taking more steps to prevent symptoms; greater use of controller medication and written treatment plans; fewer night awakenings, days with activity limitation, and school absences due to asthma; improved QOL; and fewer acute care visits, emergency department visits, and hospitalizations. In contrast, steps to manage asthma episodes, daytime symptom frequency, and school-reported absences did not differentiate the two groups. Most results were sustained over the 12 months. CONCLUSIONS ASMA is efficacious in improving asthma self-management and reducing asthma morbidity and urgent health care use in low-income urban minority adolescents.
Drug dosing in continuous renal replacement therapy: general rules

Purpose of reviewContinuous renal replacement therapy is increasingly used in the management of acute kidney injury in critically ill patients. The potential extracorporeal removal of drugs, in particular the removal of antimicrobials, is a concern to many clinicians. The results of clinical studies cannot be generalized because different treatment modalities and settings are used in heterogeneous patient populations. This review aims to provide general guidelines for drug dosing during continuous renal replacement therapy. Recent findingsThe basic principles underlying drug removal with different modalities of continuous renal replacement therapy are reviewed and general approaches for drug dosage adaptation are proposed. Dosing should consider extracorporeal clearance, mainly depending on the dose and mode of therapy, type of membrane and protein binding, but also fractional extracorporeal clearance, accounting for hepatic, metabolic and residual renal clearance. Of note, pharmacokinetic variables may be highly variable in the critically ill. Appropriate dosing of antimicrobials additionally requires the application of pharmacodynamic principles. For nontoxic antimicrobials, the clinician should prefer slight overdosing, while monitoring of plasma concentrations is crucial for drugs with a narrow therapeutic index. SummaryDrug dosage adaptation during continuous renal replacement therapy can use several approaches, which all include a degree of unpredictability and thus require maximal reliance on drug monitoring.
Systèmes de réaction-diffusion et dynamique d'interface en chimie et en biologie

L'objet de cette these est l'etude du comportement asymptotique de solutions d'equations de reaction-diffusion et leur convergence vers la solution de problemes a frontiere libre associes. Les problemes consideres interviennent dans des modeles de transition de phase en chimie et en biologie. Dans la premiere partie on etudie la limite singuliere d'une equation d'advection-reaction-diffusion modelisant un phenomene de chemotaxis. On considere un intervalle de temps arbitraire sur lequel on demontre la convergence de la solution vers la solution de viscosite d'un probleme a frontiere libre associe, ou le deplacement de l'interface est partiellement induit par sa courbure moyenne. Les methodes de demonstration s'appuient sur des arguments lies au principe du maximum et a la construction de sur- et sous-solutions au sens de la viscosite. Dans les deuxieme et troisieme parties on considere des systemes qui modelisent la separation en microphases de copolymeres en blocs. Ces systemes admettent la meme fonctionnelle de lyapunov et sont tels que l'integrale en espace de la fonction inconnue est preservee au cours du temps. Le premier systeme fait intervenir une equation parabolique d'ordre quatre. On montre la convergence vers un probleme a frontiere libre de type hele-shaw dans le cas de la symetrie spherique. Dans le deuxieme systeme l'equation d'ordre quatre est remplacee par une equation parabolique d'ordre deux avec un terme non local. On se place ici aussi dans le cas de la symetrie spherique et on demontre la convergence vers un probleme a frontiere libre, ou le deplacement de la frontiere est induit par un mouvement par courbure moyenne non local. Les methodes de demonstration s'appuient sur des estimations d'energie et sur des developpements asymptotiques d'ordre un.
What determines the spectrum of protein native state structures?

We present a brief summary of the key factors underlying protein structure, as developed in the investigations of Pauling, Ramachandran, and Rose. We then outline a simplified physical model of proteins that focusses on geometry and symmetry. Although this model superficially appears unrelated to the detailed chemical descriptions commonly applied to proteins, we show that it captures the essential elements of the chemistry and provides a unified framework for understanding the common characteristics of folded proteins. We suggest that the spectrum of protein native state structures is determined by geometry and symmetry and the role of the sequence is to choose its native state structure from this predetermined menu. Proteins 2006. © 2006 Wiley‐Liss, Inc.
Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells

ABSTRACT Weibel-Palade bodies (WPBs) are endothelial storage organelles that mediate the release of molecules involved in thrombosis, inflammation and angiogenesis, including the pro-thrombotic glycoprotein von Willebrand factor (VWF). Although many protein components required for WPB formation and function have been identified, the role of lipids is almost unknown. We examined two key phosphatidylinositol kinases that control phosphatidylinositol 4-phosphate levels at the trans-Golgi network, the site of WPB biogenesis. RNA interference of the type II phosphatidylinositol 4-kinases PI4KIIα and PI4KIIβ in primary human endothelial cells leads to formation of an increased proportion of short WPB with perturbed packing of VWF, as exemplified by increased exposure of antibody-binding sites. When stimulated with histamine, these cells release normal levels of VWF yet, under flow, form very few platelet-catching VWF strings. In PI4KIIα-deficient mice, immuno-microscopy revealed that VWF packaging is also perturbed and these mice exhibit increased blood loss after tail cut compared to controls. This is the first demonstration that lipid kinases can control the biosynthesis of VWF and the formation of WPBs that are capable of full haemostatic function. Summary: Phosphatidylinositol 4 kinases regulate the formation and function of an endothelial secretory organelle that is crucial for haemostasis in mammals.
Regulation of Rad51 Function by c-Abl in Response to DNA Damage*

The Rad51 protein, a homolog of bacterial RecA, functions in DNA double-strand break repair and genetic recombination. Whereas Rad51 catalyzes ATP-dependent pairing and strand exchange between homologous DNA molecules, regulation of this function is unknown. The c-Abl tyrosine kinase is activated by ionizing radiation and certain other DNA-damaging agents. Here we demonstrate that c-Abl interacts constitutively with Rad51. We show that c-Abl phosphorylates Rad51 on Tyr-54 in vitro. The results also show that treatment of cells with ionizing radiation induces c-Abl-dependent phosphorylation of Rad51. Phosphorylation of Rad51 by c-Abl inhibits the binding of Rad51 to DNA and the function of Rad51 in ATP-dependent DNA strand exchange reactions. These findings represent the first demonstration that Rad51 is regulated by phosphorylation and support a functional role for c-Abl in regulating Rad51-dependent recombination in the response to DNA damage.
A polynomial-based approach to design controllers of non-minimum phase nonlinear systems

In this paper we developed a control approach of nonlinear systems with non-minimum phase. The proposed approach is based on the exact input-output linearization and the Lyapunov theory. The main contribution in this work is to solve the problem of the instable internal dynamics. An application of the obtained nonlinear control law to the chemical reactor system stabilization gives very interesting results. Numerical Simulations are presented to illustrate the efficiency of the proposed scheme.
SME Customers’ Perception on Banking on Shared Value in Bangladesh

The perception of SME customers regarding banking on shared value reflects their values, beliefs, and general endorsement of SME products and services offered by banks. In practice, their perception denotes the extent to which they are benefiting from opening and maintaining accounts, depositing and withdrawing money, obtaining loans, maintaining communications and ensuring financial, information, and privacy rights. The results indicate that banks are creating shared value in cases of customer rights, account opening and maintenance, and deposit/withdrawal of money. However, the banks are limiting customer shared value in obtaining SME loans. The study has identified high rate of lending, huge processing costs, unusual delay in sanctioning loans, complexity in documentation and difficulties in providing collateral against loan as the core problems in obtaining SME loans.
Success Factors of Adoption of Mobile Applications in Rural India: Effect of Service Characteristics on Conceptual Model

The framework for this research is the unified theory of acceptance and use of technology. The increasing rural proliferation of mobile services has created a unique opportunity to deliver to the rural users information and services through innovative mobile applications. This chapter develops a conceptual model of factors that make a rural mobile application successful and that are the barriers to its implementation. The conceptual framework developed has been validated by a questionnaire based field survey using structural equation modeling (AMOS). The chapter explores how the conceptual model is impacted by the service characteristics. The contribution of this research to further the understanding of technology adoption models for rural mobile applications has been discussed. The findings of the study have been corroborated with similar research focusing on adoption of rural mobile applications. The practical significance as to how the research findings help in successful implementation of mobile applications has been presented.
Neck lift.

BACKGROUND The treatment of the aging neck is still a challenge to the plastic surgeon. OBJECTIVE The results of anatomic studies of the platysma muscle and its role in the treatment of the aging neck are presented. METHODS Dissection of 50 cadavers revealed differences in the distribution of the medial fibers of the platysma muscle in the suprahyoid region that could significantly affect surgical results. A 4-cm incision at the submental area, 0.3 to 0.4 mm behind the submental crease, and submental skin undermining permitted visualization of the medial fibers of the platysma. The medial fibers were dissected laterally and excess muscle removed. The fibers were sutured without tension to the median line, followed by a medial section at the level of the cricoid cartilage. RESULTS With the use of the approach described here, very good results were obtained in the treatment of patients who presented with deformities in the median line of the neck. CONCLUSIONS Appropriate treatment of the platysma, based on anatomic analysis and facilitated by the submental approach, is the key to optimal results in the treatment of the aging neck. (Aesthetic Surg J 2003;23:165-169.).
DNA fingerprinting of medically important microorganisms by use of PCR

Selected segments of any DNA molecule can be amplified exponentially by PCR. This technique provides a powerful tool to detect and identify minimal numbers of microorganisms. PCR is applicable both in diagnosis and in epidemiology. By amplification of hypervariable DNA domains, differences can be detected even among closely related strains. PCR fingerprinting is a valuable tool for medical microbiologists, epidemiologists, and microbial taxonomists. The current state of PCR-mediated genotyping is reviewed, and a comparison with conventional molecular typing methods is included. Because of its speed and versatility, PCR fingerprinting will play an important role in microbial genetics, epidemiology, and systematics.