Miracle-dz/UniFAR-FTUs huggingface dataset:
Contributions à l'analyse des systèmes industriels et aux problèmes d'ordonnancement à machines parallèles flexibles : application aux laboratoires de contrôle qualité en industrie pharmaceutique

Dans cette these, nous abordons deux thematiques tres differentes du genie industriel, mises en oeuvre sur un meme cas d'application industriel. Tout d'abord, nous nous interessons a l'analyse des systemes industriels en integrant deux courants de pensee : la modelisation d'entreprise d'une part, et l'amelioration des systemes industriels d'autre part. Nous proposons une grille d'analyse/action basee sur la modelisation d'entreprise et permettant de mettre en evidence les dysfonctionnements du systeme industriel et les instruments d'amelioration a mettre en oeuvre. Un cas d'application est developpe sur notre problematique industrielle. Ensuite, un probleme d'ordonnancement original est issu du precedent cas d'application. Il s'agit d'un atelier a machines paralleles flexibles et necessitant des ressources secondaires (outils et intervention d'operateurs), avec temps de preparation importants, mais sans contrainte de precedence entre les operations d'un job. Nous etudions le critere de la somme des retards des jobs. Deux approches sont proposees pour ce probleme : par heuristique et par recuit simule. Pour l'approche heuristique, une regle appelee ATCTRS est developpee. Elle cherche a realiser un compromis entre le retard d'une operation et la bonne occupation de la machine. Pour l'approche par meta-heuristique, nous etudions principalement une structure de voisinage adaptee au probleme a resoudre.
Categorical and gradient properties of assimilation in alveolar to velar sequences: evidence from EPG and EMA data

Abstract Place assimilation in English is now widely considered to be a gradual phonetic, not categorical process. This view is partly based on previous EPG evidence of partial alveolar assimilations which lack complete stop closure on the alveolar ridge but show a residual tongue blade/body gesture. This study reports EPG data from 10 speakers producing, at varying rates of speech, two experimental sequences, /n#k/ and /n#k/ (the latter a lexical velar–velar sequence with which apparent cases of complete assimilation can be compared). In fast speech, four distinct assimilatory strategies were identified. Two subjects never assimilated, four always assimilated in what appeared to be a complete fashion and the remaining four were the most interesting, showing considerable intra-speaker variability. Two of these four produced the expected continuum of assimilatory forms including partials. Unexpectedly, the other two produced either full alveolars or complete assimilations in the manner of a binary opposition. Follow-up EMA analysis yielded no evidence of the reduced coronal gestures found to be absent in the EPG-only data for two the speakers who, when they assimilated, did so in a complete fashion. Although no claims are made regarding higher-order representations, we interpret this as evidence of marked individual differences in assimilation strategy.
Drug-Bound CCR 5 and Extracellular Loop Domains of Antagonists Depends on both N-Terminal Cross-Resistance to Other CCR 5 A Maraviroc-Resistant HIV-1 with Narrow

Published Ahead of Print 11 August 2010. 2010, 84(20):10863. DOI: 10.1128/JVI.01109-10. J. Virol. Martin, Steven G. Deeks and Robert W. Doms Elizabeth A. Henning, Frederick D. Bushman, Jeffrey N. Sinha, Jessamina E. Harrison, Caroline Agrawal-Gamse, John C. Tilton, Craig B. Wilen, Chukwuka A. Didigu, Rohini Drug-Bound CCR5 and Extracellular Loop Domains of Antagonists Depends on both N-Terminal Cross-Resistance to Other CCR5 A Maraviroc-Resistant HIV-1 with Narrow
The Impact of Child Health and Nutrition on Education in Developing Countries: Theory, Econometric Issues, and Recent Empirical Evidence

Analysis of the impact of child health and nutrition on subsequent school performance is hampered by many difficulties. Research using retrospective data is complicated by the possibility that unobserved factors may determine both nutrition and education outcomes, which will generate correlation between these two outcomes that is not necessarily causal. Randomized trials offer a clearer method for identifying causal relationships, but they are relatively rare and encounter several difficulties in practice. This paper examines theory, estimation strategies, and recent empirical evidence to assess the current state of knowledge on the impact of child health and nutrition on education outcomes in developing countries.
An analysis of tax knowledge base system usage behaviour at KPP Madya South Jakarta i

The Directorate General of Taxation has established an online repository called Tax Knowledge Base or TKB. TKB has been widely recognized and used by tax authorities, albeit not maximally. This study used a quantitative descriptive method to analyse constructs of the Unified Theory of Acceptance and Use of Technology to specifically figure out TKB use at KPP Madya South Jakarta I with a sample size of 88. A significant effect was demonstrated by Performance Expectancy on Behavioural Intention, Facilitating Condition and Behavioural Intention to Use Behaviour. Insignificance was apparent in the effect of Effort Expectancy and Social Influence on Use Behaviour. This study recommends that the Directorate General of Taxation should require tax authorities to use TKB on a daily basis.
Discrete Duty-Cycle-Control Method for Direct Torque Control of Induction Motor Drives With Model Predictive Solution

In this paper, a new duty cycle control method is proposed to reduce torque and flux ripples of the conventional direct torque control (DTC). In the proposed method, a new approach is initially introduced to select the appropriate active voltage vector (VV) precisely. Then by inserting the zero VV along with the selected one, a finite set of new candidate VVs with different duty cycles are synthesized. Finally, the model predictive control method is employed to select the appropriate VV among the candidate ones to reduce flux and torque errors. Simulation and experimental studies are conducted to show the good performance and the superiority of the proposed method over classical DTC and model predictive control methods. As a result, lower torque and flux ripples are achieved in the proposed method. Furthermore, the proposed method works with almost a fixed switching frequency for all speed ranges.
Talking “Among Us”: How Women From Different Racial–Ethnic Groups Define and Discuss Menopause

Against a backdrop of scant literature on commonalities and differences among diverse groups of menopausal women within the United States, and little attempt by scholars in any country to study the ways in which both privilege and oppression can shape women's ideas and experiences of menopause, in this study, 61 menopausal women of varied racial–ethnic and class locations in a Midwestern state were asked about the different meanings and experiences of menopause. African American women and Chicanas, particularly working-class women, viewed menopause as a positive experience, whereas many middle-class European American women discussed more negative feelings. Women of color were more likely than European Americans to report talking about menopause with same-race, same-sex friends only. While women of color discussed their knowledge of European American women's menopause, the latter lacked knowledge of other women's experiences. Women's lived experiences with privilege and oppression also surfaced in the interviews. The authors argue that when scholars listen to how women discuss menopause experiences, commonalities among women by gender, and differences among women by race, and class are exposed. The presence of racial–ethnic differences in these pilot data suggests the importance of more comparative studies on reproductive aging both in the United States and abroad.
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

We developed an in vitro expression system for accurate kinetic analyses of the inhibition of the human prostaglandin H synthase isozymes (hPGHS-1 and -2) by nonsteroidal anti-inflammatory drugs (NSAIDs). Assays of instantaneous inhibition in which enzyme, 10 microM arachidonate, and an NSAID were mixed simultaneously were used to determine apparent affinities of 14 common NSAIDs for hPGHS-1 and hPGHS-2. All NSAIDs except salicylate had appreciable apparent affinities (IC50 < or = 100 microM) for hPGHS-1. Most NSAIDs also exhibited appreciable affinities toward hPGHS-2, but three prominent exceptions were indomethacin, piroxicam and phenylbutazone. We subsequently performed measurements of time-dependent inhibition in which either (a) enzyme and an NSAID were preincubated before substrate was added to initiate the reactions or (b) recovery of activity after time-dependent inhibition was measured using intact cells preincubated with various NSAIDs. Indomethacin, flurbiprofen, meclofenamate and diclofenac, but not ibuprofen, piroxicam or phenylbutazone, caused time-dependent inhibition of both hPGHS-1 and -2 in vitro. For cells pretreated with flurbiprofen or meclofenamate, hPGHS-2 activities, but not hPGHS-1 activities, were recovered relatively rapidly; with indomethacin, recoveries of hPGHS-1 and hPGHS-2 activities were both slow. hPGHS-2 is thought to be the target of NSAIDs acting as anti-inflammatory agents. However, our results indicate that neither measurements of affinities of NSAIDs for hPGHS-2 conducted in vitro with 10 microM arachidonate nor measurements of time-dependent inhibition of hPGHS-2 always predict whether a compound (e.g., piroxicam or phenylbutazone) has anti-inflammatory activity in vivo. (ABSTRACT TRUNCATED AT 250 WORDS)
[Correlation between pelvic adhesions and pain symptoms of endometriosis].

OBJECTIVE To study the incidence of pelvic adhesions in endometriosis (EM) and the relationship between pelvic adhesions and pain symptoms. METHODS The incidence of pelvic adhesions, dysmenorrhea, chronic pelvic pain, dyspareunia, dyschizia in 480 patients with EM were studied retrospectively to evaluate the correlation between pelvic adhesions and the degree of pain symptoms. In accordance with the revised American Fertility Society classification (r-AFS), it was observed that 155 cases were in Stage I, 33 cases were in stage II, 108 cases were in stage III and 184 were cases in stage IV. RESULTS (1) Among 480 cases with EM, 72.3% (347/480) of patients have pelvic adhesions simultaneously, of which 25.2% (39/155) patients were in Stage I, 78.8% (26/33) patients were in Stage II, 90.7% (98/108) patients were in Stage III and 100.0% (184/184) patients were in Stage IV. It was found that positive correlation existed between the degree of pelvic adhesions and clinical staging of EM (r(s) = 0.870, P < 0.01). (2) 61.0% (293/480) of patients presented dysmenorrhoea, of which the percentages of mild, moderate and severe dysmenorrhea were 52.2% (153/293), 26.6% (78/293), 21.2% (62/293), respectively. The rate of patients presenting chronic pelvic pain (CPP), dyspareunia and dyschezia were 23.8% (114/480), 15.4% (74/480) and 7.1% (34/480), respectively. (3) Ovarian adhesions was positively correlated with dysmenorrhea and CPP (r(s) = 0.367 and 0.267, P < 0.01). Adhesion of the bottom and posterior wall of uterus was positively correlated with dysmenorrhea and CPP (r(s) = 0.336, 0.164, P < 0.01); adhesions of fallopian tubes were positively correlated with dysmenorrhea, CPP and dyschezia (r(s) = 0.283, 0.225 and 0.159, P < 0.01). Adhesions of rectum was positively correlated with dysmenorrhea (r(s) = 0.101, P < 0.05). In addition to dyspareunia, the degree of pelvic adhesions was positively correlated with dysmenorrhea, CPP and dyschezia (r(s) = 0.470, 0.273, 0.132, P < 0.01). CONCLUSION Pelvic adhesions are characteristic lesions of endometriosis, the site and degree pelvic adhesions are closely correlated with pain symptoms.
Teacher Pension Workshop: Connecting Evidence-Based Research to Pension Reform: Pay For Seniority: Do Back-Loaded Retirement Benefits Retain Government Employees?

This study explores the effect of seniority pay on employee retention in the U.S. public sector. State-government employees in Michigan transitioned from a defined-benefit pension with 10-year vesting to a defined-contribution plan with immediate vesting. Participation in either plan depends on date of hire, permitting a regression-discontinuity research design. The shift away from back-loaded retirement benefits caused an eight percentage-point decrease in the probability of remaining in state service to earn 10 years of tenure. The probability of leaving with four to nine years of tenure increased commensurately. Older, highly educated workers were highly responsive to retirement-plan incentives, whereas younger workers did not adjust their labor supply. ∗I am indebted to Joshua Goodman, Lawrence Katz, Jeffrey Liebman, Brigitte Madrian, Geoffrey Sanzenbacher, Richard Zeckhauser, and participants in the Harvard Kennedy School’s Doctoral Research Seminar for invaluable comments and suggestions. All remaining errors are my own. This project was funded by grants from the Taubman Center for State and Local Government and the Lab for Economic Applications and Policy at Harvard University. The views expressed in this article do not represent the Center for Retirement Research or Boston College.
Habitat Fragmentation and Native Bees: a Premature Verdict?

Few studies directly address the consequences of habitat fragmentation for communities of pollinating insects, particularly for the key pollinator group, bees (Hymenoptera: Apiformes). Bees typically live in habitats where nesting substrates and bloom are patchily distributed and spatially dissociated. Bee studies have all defined habitat fragments as remnant patches of floral hosts or forests, overlooking the nesting needs of bees. Several authors conclude that habitat fragmentation is broadly deleterious, but their own data show that some native species proliferate in sampled fragments. Other studies report greater densities and comparable diversities of native bees at flowers in some fragment size classes relative to undisrupted habitats, but find dramatic shifts in species composition. Insightful studies of habitat fragmentation and bees will consider fragmentation, alteration, and loss of nesting habitats, not just patches of forage plants, as well as the permeability of the surrounding matrix to interpatch movement. Inasmuch as the floral associations and nesting habits of bees are often attributes of species or subgenera, ecological interpretations hinge on authoritative identifications. Study designs must accommodate statistical problems associated with bee community samples, especially non-normal data and frequent zero values. The spatial scale of fragmentation must be appreciated: bees of medium body size can regularly fly 1–2 km from nest site to forage patch. Overall, evidence for prolonged persistence of substantial diversity and http://www.ecologyandsociety. org/vol5/iss1/art3/ (1 of 10) [9/5/2008 11:01:43 AM] Conservation Ecology: Habitat Fragmentation and Native Bees: A Premature Verdict? abundances of native bee communities in habitat fragments of modest size promises practical solutions for maintaining bee populations. Provided that reserve selection, design, and management can address the foraging and nesting needs of bees, networks of even small reserves may hold hope for sustaining considerable pollinator diversity and the ecological services pollinators provide.
Central nucleus of amygdala projections to rostral ventrolateral medulla neurones activated by decreased blood pressure

The central nucleus of amygdala (CeA) participates in cardiovascular regulation during emotional behaviour but it has not been established whether any of these effects are mediated through its direct connections to blood pressure‐regulating neurones in the rostral ventrolateral medulla (RVLM). The RVLM contains barosensitive neurones that maintain resting blood pressure via their projections to sympathetic preganglionic neurones in the thoracic spinal cord. In this study on rats, we used combined anterograde neuronal tracing of CeA projections with confocal and electron microscopic immunohistochemical detection of phenylethanolamine‐N‐methyltransferase, the adrenaline‐synthesizing enzyme present in C1 catecholamine neurones of the RVLM, and Fos, the protein product of the c‐fos proto‐oncogene. Fos expression in barosensitive neurones was stimulated by an intravenous infusion of the hypotensive agent sodium nitroprusside. Injection of the tracer biotin dextran amine (10‐kDa form) into the CeA resulted in anterograde labelling of axons and varicosities throughout the RVLM without retrograde labelling of somata in any brain area. With confocal microscopy, presumptive CeA terminals were found in close apposition to adrenergic (phenylethanolamine‐N‐methyltransferase‐immunoreactive) and non‐adrenergic neurones that displayed Fos‐immunoreactive nuclei in response to decreased blood pressure. Electron microscopic analysis confirmed that some labelled terminals of CeA axons made synaptic contact with c‐fos‐activated adrenergic neurones. The results provide evidence that cardiovascular influences elicited from the CeA during stressful events may be mediated, at least in part, via monosynaptic neural projections to barosensitive sympathetic blood pressure‐regulating neurones in the RVLM.
PSYCHOMETRIC PROPERTIES OF A SCALE TO MEASURE ADAPTATION FOR IMMIGRANT POPULATIONS : THE CULTURAL BELIEFS , BEHAVIORS , AND ADAPTATION PROFILE ( CBBAP

Julia Shiang, Ph.D. Pacific Graduate School of Psychology Maria A. Gartstein, Ph.D. Pacific Graduate School of Psychology Abstract The Cultural Beliefs, Behaviors, and Adaptation Profile (CBBAP), a new measure of independence and interdependence, acculturation-related constructs, has been developed and evaluated with a group of Chinese Americans and participants of European heritage (N=230). This study presents data supporting reliability (internal consistency) and validity (criterion and construct) of this multidimensional instrument. Results of a factor analysis indicated a five factor solution, including the following dimensions: Reciprocity, Family Integrity, Influence of Peers’ Ideas, Values of Peers’ and Family’s Ideas, Self-Reliance, and Harmony at Work. These CBBAP factors demonstrated adequate internal consistency and correlations with established measures of acculturation (e.g., SL-ASIA; Suinn, Rickard-Figueroa, Lew, & Virgil, 1987), and demographic variables (e.g., first or second generation in America). These findings are discussed in the context of their clinical utility.
The Next Frontier for Mobile Based Augmented Reality: An Evaluation of AR Uptake in India

 Abstract — Augmented and Virtual Realties is quickly becoming a hotbed of activity with millions of dollars being spent on R & D and companies such as Google and Microsoft rushing to stake their claim. Augmented reality (AR) is however marching ahead due to the spread of the ideal AR device – the smartphone. Despite its potential, there remains a deep digital divide between the Developed and Developing Countries. The Technological Acceptance Model (TAM) and Hofstede cultural dimensions also predict the behaviour intention to uptake AR in India will be large. This paper takes a quantified approach by collecting 340 survey responses to AR scenarios and analyzing them through statistics. The Survey responses show that the Intention to Use, Perceived Usefulness and Perceived Enjoyment dimensions are high among the urban population in India. This along with the exponential smartphone indicates that India is on the cusp of a boom in the AR sector.
SUMOylation and De-SUMOylation: Wrestling with Life's Processes*

The small ubiquitin-like modifier (SUMO) is a ubiquitin-like protein that covalently modifies a large number of cellular proteins. SUMO modification has emerged as an important regulatory mechanism for protein function and localization. SUMOylation is a dynamic process that is mediated by activating (E1), conjugating (E2), and ligating (E3) enzymes and readily reversed by a family of ubiquitin-like protein-specific proteases (Ulp) in yeast and sentrin/SUMO-specific proteases (SENP) in human. This review will focus on the de-SUMOylating enzymes with special attention to their biological function.
The hepatic wedge pressure and venogram vs. the intraparenchymal liver pressure and venogram.

Abstract Percutaneous hepatic intraparenchymal and hepatic wedge studies, including venography and pressure measurements, were compared. Both techniques provide almost identical radiographic information in most cases. Although a percutaneous transthoracic intraparenchymal study is simpler to perform, the hepatic wedge technique (via the femoral vein) is subject to fewer artifacts of pressure measurement and also allows evaluation of free hepatic vein and inferior vena caval pressures.
The ‘ToyBox‐study’ obesity prevention programme in early childhood: an introduction

The rates of overweight and obesity among adults and children remain high (1), even though in some countries the speed of increase seems to be levelling off (2). Targeting preschool-aged children is central to preventing obesity because development at this life stage is more malleable than it is in later childhood and adolescence (3,4), and risk factors for overweight can be more easily modified (5). In addition, early foodor physical activity-related experiences may influence the acquisition of diverse eating habits and engagement in physical activity in later life (6–10). This early development and adoption of desired eating and physical activity habits may help prevent physiological and hormonal dys-regulations. This emphasizes early childhood as the ideal window in time to intervene. Several studies have highlighted the importance of integrated approaches to physical activity and healthy eating in preventing childhood overweight (11). Although different legislation applies regarding pre-primary education in different countries in Europe, the majority of children of preschool age (95–100%) attend kindergartens (http:// www.eurydice.org). As such, the kindergarten seems to be the ideal setting to implement concerted health promoting actions. The ToyBox-study (short for ‘Multifactorial evidence based approach using behavioural models in understanding and promoting fun, healthy food, play and policy for the prevention of obesity in early childhood’ http://www. toybox-study.eu) is a European Union (EU)-funded study (2010–2013) aiming to develop and test an innovative and evidence-based obesity prevention programme for children aged 4–6 years. ToyBox comprises a multidisciplinary team of 15 partners across the EU: a variety of experts are involved in this project such as public health experts, epidemiologists, nutritionists, physical activity experts, educational scientists, psychologists, behavioural scientists, paediatricians, early childhood psychologists, political scientists and health economists. The consortium consists of 11 universities, 1 research institute, 1 health promotion institute, 1 advocacy group, and a small-medium enterprise representing all regions of Europe, and all of them have ample experience in conducting and coordinating multicentre international research as well as undertaking dissemination activities to all relevant stakeholders. ToyBox-study will: