Miracle-dz/UniFAR-FTUs huggingface dataset:
Wages, Seniority and Separation Rates in a Stochastic Productivity Model: A Comparative Perspective1

We discuss a theoretical framework for the job duration of individual workers and the evolution of the wage rate during that job assuming that individual productivity follows a geometric Brownian. A comparative overview of job search, random learning and random growth models is put forward as background to the literature on job tenure distribution. The random growth model fits best the humpshaped tenure profile observed in data on job separation rates and is consistent with empirical evidence that log wages follow a random walk. We provide a synopsis of the persisting debate on the returns to job seniority adding a non-deterministic tenure profile perspective. The specification of the model allows the application of option theory to calculate the value of a job and the optimal job separation rule. An extension to the initial model adding log firm size is introduced. I. Sebastian Buhai 3
Effect of l-arginine on life quality in patients with hypertensive disease and chronic obstructive pulmonary disease

The aim: of the research was to improve the effectiveness of pharmacotherapy for patients with hypertensive disease and co-existent chronic obstructive pulmonary disease using an exogenous nitric oxide donor – L-arginine through the correction of structural and functional indices of the heart, pulmonary ventilation and according to patients’ life quality. Materials and Methods: The study included 102 patients with stage II second-degree/third-degree hypertensive disease; among them, there were 82 patients with hypertensive disease and co-existent chronic obstructive pulmonary disease and 20 patients with hypertensive disease (essential hypertension) of a similar stage and degree at the age of 65.5±4.12 years. According to treatment, 82 patients with hypertensive disease and chronic obstructive pulmonary disease were divided into two homogeneous groups according to age, sex, duration of hypertensive disease and chronic obstructive pulmonary disease. Group I (the control group) included 40 patients undergoing basic therapy only. Group II (the main group) included 42 patients, who, in addition to basic therapy, received L-arginine. Results and Discussion: There was noted a precipitating effect of chronic obstructive pulmonary disease on the clinical course of hypertensive disease through the worsening of the indicators of the cardiorespiratory system. In patients with hypertensive disease and co-existent chronic obstructive pulmonary disease, the left ventricle was characterized by an increase in metric and volumetric indices – end-systolic dimensionincreased by 17.8%, end-systolic volume increased by 44.4% compared to patients with isolated hypertensive disease (p
Distributed Graph Convolutional Networks to Generate Representative Vertex Embeddings - Survey and Problem context

The application of deep learning models to the task of Graph Mining has become an area of active research in recent years. The success of deep neural networks in extracting information from various other forms of data such as images, text and speech as well as the fact that large amounts of data are naturally representable as graphs, has pushed researchers to experiment with applying deep learning to the task of graph mining. The first Graph Neural Network proposed, (Scarselli et al., 2009) implemented a function τ : (G(V,E), v)→ Rd that mapped a graph G and a single vertex v ∈ G(V ) to an m-dimentional vector. The mdimentional vector is a fixed length state representation vector that embeds the neighborhood information for v (Zhou et al., 2018). This fixed length embedding can be used to create a representative output for the vertex v based on a goal. For example, just as fixed length word-embeddings, such as those generated by word2vec, can be used in Natural Language Processing where the goal is defined by a specific NLP task, these vertex-embeddings can be used as inputs to graph mining tasks. The GNN, in this form, though experimentally shown to be good at mining the structural information from a graph, suffers from not being able to extract features hierarchically, like other standard deep learning models such as Convolutional Neural Networks do. However, since the introduction of GNNs, much progress has been made building on the idea of generating vertex embeddings based on a vertex’s neighborhood.
Photocatalytic Decomposition of Methyl Formate over TiO2-Supported Pt Metals

The photoinduced vapor-phase decomposition of methyl formate was investigated on pure and on Pt-metals-promoted TiO2. Infrared spectroscopic studies revealed that illumination induced the dissociation of molecularly adsorbed methyl formate to formate on pure TiO2 even at ∼186 K. This process is indicated by the appearance of the absorption band at 1580–1590 cm–1 due to asymmetric stretch of formate species. The extent of the dissociation is increased with the time of irradiation. Deposition of Pt metals on TiO2 only slightly influenced this process. The photocatalytic decomposition of methyl formate vapor on pure TiO2 occurred to only a limited extent at 300 K, but the deposition of Pt metals on TiO2 appreciably enhanced the extent and the rate of photodecomposition. Nevertheless the photocatalytic reaction of methyl formate proceeded more slowly compared to that of formic acid on the same catalysts, and produced more CO. Addition of H2O to the methyl formate decreased the CO/H2 ratio by a factor of 4. Wh.
Characterization of non‐response to cardiac resynchronization therapy by post‐procedural computed tomography

Causes of non‐response to cardiac resynchronization therapy (CRT) include mechanical dyssynchrony, myocardial scar, and suboptimal left ventricular (LV) lead location. We aimed to assess the utility of Late Iodine Enhancement Computed Tomography (LIE‐CT) with image subtraction in characterizing CRT non‐response.
Giardia intestinalis can interact, change its shape and internalize large particles and microorganisms

Abstract Giardia intestinalis is a parasitic protozoan that inhabits its vertebrate hosts' upper small intestine and is the most common cause of waterborne diarrhoea worldwide. Giardia trophozoites present few organelles, and among them, they possess peripheral vesicles (PVs), which are considered an endosomal–lysosomal system. All experimental procedures carried out until now indicate that Giardia ingests macromolecules by fluid-phase and receptor-mediated endocytic pathways. Still, there is no description concerning the interaction and ingestion of large materials. Here, we tested Giardia's capacity to interact with large particles; once, in vivo, it inhabits an environment with a microbiota. We tested protozoan interaction with yeasts, bacteria, latex beads, ferritin and albumin, in different times of interaction and used several microscopy techniques (light microscopy, scanning electron microscopy and transmission electron microscopy) to follow their fate. Giardia interacted with all of the materials we tested. Projections of the plasma membrane similar to pseudopods were seen. As albumin, small markers were found in the PVs while the larger materials were not seen there. Large vacuoles containing large latex beads were detected intracellularly. Thus, we observed that: (1) Giardia interacts with large materials; (2) Giardia can display an amoeboid shape and exhibit membrane projections when in contact with microorganisms and large inorganic materials; (3) the region of the exit of the ventral flagella is very active when in contact with large materials, although all cell surface also present activity in the interactions; (4) intracellular vacuoles, which are not the PVs, present ingested large beads.
OXIDATION OF A DIMERIC NICKEL THIOLATE COMPLEX WITH O2

Reaction of dimeric bis{[μ-(2-mercaptoethyl)(2-mercaptoethyl)methylaminato(2−)]nickel(II)}, 1, with either O2 or H2O2 leads to the formation of a dimeric product, bis{[μ-(2-mercaptoethyl)(2-sulfina.
An Unknown Non-denitrifier Bacterium Isolated from Soil Actively Reduces Nitrous Oxide under High pH Conditions

A nitrous oxide (N2O)-consuming bacterium isolated from farmland soil actively consumed N2O under high pH conditions. An acetylene inhibition assay did not show the denitrification of N2 to N2O by this bacterium. When N2O was injected as the only nitrogen source, this bacterium did not assimilate N2O. A polymerase chain reaction demonstrated that this bacterium did not have the typical nosZ gene. This bacterium belonged to Chitinophagaceae, but did not belong to known families that include bacteria with the atypical nosZ. This is the first study to show that a non-denitrifier actively reduces N2O, even under high pH conditions.
Avaliação da difusividade e permeabilidade do hidrogênio em diafragmas confeccionados em ligas 625

As ligas de niquel sao muito utilizadas na industria por apresentar excelentes propriedades mecânicas e otima resistencia quimica em diferentes ambientes. O objetivo do trabalho foi estudar uma alternativa eficiente no campo da difusividade e permeabilidade de hidrogenio utilizando como material de estudo a liga INCONEL 625, sob a condicao solubilizada. Visando estudar o comportamento do hidrogenio para a liga sob uma condicao precipitada, foi realizado um tratamento termico de envelhecimento a 650°C durante 24 horas. Foram observadas as caracteristicas microestruturais da liga, tanto na condicao solubilizada como tambem para a condicao envelhecida; para a ultima, observou-se uma precipitacao continua ao longo dos contornos de graos. Realizou-se ensaios de permeacao de hidrogenio via gasosa nas amostras sob as condicoes solubilizada e envelhecida, para uma faixa de temperaturas compreendidas entre 100°C e 300°C, sob pressao de carregamento constante de hidrogenio de 8 bar. Verificou-se que a precipitacao foi capaz de reduzir tanto a difusividade quanto a permeabilidade do hidrogenio em comparacao a condicao solubilizada. A fim de estudar como a adicao de uma barreira fisica poderia influenciar no comportamento de permeacao do hidrogenio, foi depositada uma fina camada de ouro na superficie da amostra sob condicao solubilizada, onde uma espessura de 100 nm medida via microscopia de forca atomica foi capaz de impedir o ingresso do hidrogenio no substrato a 100°C.
Combination treatment with tenapanor and sevelamer synergistically reduces urinary phosphorus excretion in rats.

The majority of patients with chronic kidney disease (CKD) receiving dialysis do not reach target serum phosphorus concentrations, despite treatment with phosphate binders. Tenapanor is a non-binder, sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor that reduces paracellular intestinal phosphate absorption. This pre-clinical study evaluated the effect of tenapanor and varying doses of sevelamer carbonate on urinary phosphorus excretion, a direct reflection of intestinal phosphate absorption. We measured 24-hour urinary phosphorus excretion in male rats assigned to groups dosed orally with vehicle or tenapanor (0.3 mg/kg/day) and provided a diet containing varying amounts of sevelamer (0-3% w/w). We also evaluated the effect of the addition of tenapanor or vehicle on 24-hour urinary phosphorus excretion to rats on a stable dose of sevelamer (1.5% w/w). When administered together, tenapanor and sevelamer decreased urinary phosphorus excretion significantly more than either tenapanor or sevelamer alone across all sevelamer dose levels. The Bliss statistical model of independence indicated that the combination was synergistic. A stable sevelamer dose (1.5% w/w) reduced mean (±standard error of the mean) urinary phosphorus excretion by 42±3% compared with vehicle; together, tenapanor and sevelamer reduced residual urinary phosphorus excretion by an additional 37±6% (P < 0.05). While both tenapanor and sevelamer reduce intestinal phosphate absorption individually, administration of tenapanor and sevelamer together results in more pronounced reductions in intestinal phosphate absorption than if either agent is administered alone. Further evaluation of combination tenapanor plus phosphate binder treatment in patients receiving dialysis with hyperphosphatemia is warranted.
Kinetic Study on Mercury HG (II) Removal by CNT

Kinetic of modeling data is necessary for the industrial use of adsorption. Under changed conditions, kinetic offers evidence for operational conditions for designing and optimizing effective situations for removing the pollutant. The pseudo second-order equation was used in this study in order to investigate the mechanism of adsorption of mercury by the CNTs and the potential rate-controlling steps, such as mass transport and chemical reactions. The interaction model shows how contact with different pH affects the residual concentration of the mercury at two different times. The first (contact time of 20 minutes) showcase of the removal of the mercury does not reduce much when the pH varies from pH 5 to pH 8. The second (contact time of 120 minutes) however shows that the pH affects the removal of mercury at pH 5, the residual concentration was lower compared to the residual concentration at pH 8.
Metabolic Responses to Intermittent Hypoxia Are Regulated By Sex And Estradiol In Mice.

The roles of sex and sex-hormones on the metabolic consequences of intermittent hypoxia (IH - a reliable model of sleep apnoea) are unknown. We used intact male or female mice, and ovariectomized (OVX) females treated with vehicle (Veh) or estradiol (E2) and exposed to normoxia (Nx) or IH (6% O2, 10 cycles/hour, 12 hours/day, 2 weeks). Mice were then fasted for 6 hours, and we measured fasting glucose and insulin levels and performed insulin or glucose tolerance tests (ITT, GTT). We also assessed liver concentrations of glycogen, triglycerides (TG), and expression levels of genes involved in aerobic or anaerobic metabolism. In males, IH lowered fasting levels of glucose and insulin, slightly improved glucose tolerance, but altered glucose tolerance in females. In OVX-Veh females, IH reduced fasting glucose and insulin levels, and strongly impaired glucose tolerance. E2 supplementation reversed these effects and improved HOMA-β, a marker of pancreatic glucose-induced insulin released. IH decreased liver TG concentration in males and slightly increased glycogen in OVX-Veh females. Liver expression of glycolytic (LDHA) and mitochondrial (Citrate synthase, PDHA1) genes were reduced by IH in males and in OVX-Veh females, but not in intact or OVX-E2females. We conclude that 1) IH reduced fasting levels of glycemia in males and in ovariectomized females. 2) IH improves glucose tolerance only in males. 3) In females IH decreased glucose tolerance, this effect was amplified by ovariectomy, and reversed by E2 supplementation. 4) During IH exposures, E2 supplementation appears to improve pancreatic β cells functions.
Molecular Modeling of 3,8-dihydroxy-3-(hydroxymethyl)-6-methoxy-4,5-dimethylisochroman-1-one tautomersusing MOPAC Software

An isocoumarin type of compound known as 3,8-dihydroxy-3-(hydroxymethyl)-6-methoxy-4,5-dimethylisochroman-1-one ( 2 ) was studied for the molecular modeling using MOPAC. This compound that was originally isolated from the culture broth of Leptosphaeria sp. KTC 727 existed in anomeric tautomerization that could not be purified by chromatographic technique. Previous investigations revealed that the (3 R *,4 S *)- 2 major tautomer is more stable and thus the principal component of the tautomeric pair. This study however, provided new evidence and confirmed the aforementioned claim via theoretical calculation approach. Moreover, a plausible biogenic reaction pathway for the interconversion between major and minor tautomers is likewise proposed.
B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healthy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study.

BACKGROUND Concentrations of B-type natriuretic peptide (BNP) reflect myocardial distension and stress, and are associated with poor prognosis in patients with cardiovascular disease. Accordingly, we hypothesized that concentrations of BNP would be associated with indices of adverse left ventricular (LV) remodeling and early stages of LV systolic and diastolic dysfunction in healthy participants from the general population. METHODS We measured BNP in 1757 women and 1677 men free from known coronary heart disease participating in the prospective observational Akershus Cardiac Examination 1950 Study. All study participants underwent extensive cardiovascular phenotyping at baseline, including detailed echocardiography with assessment of indexed LV mass (LVMI), diastolic [tissue Doppler e', E/e' ratio, indexed left atrial volume (LAVI), maximal tricuspid regurgitation velocity (TRVmax), and E/A ratio], and systolic [global longitudinal strain (GLS) and LV ejection fraction (LVEF)] function. RESULTS Study participants with the highest BNP concentrations had higher GLS, LVMI, e', E/e' ratio, LAVI, TRVmax, and E/A ratio. In adjusted analyses, both GLS and LVEF exhibited significant nonlinear associations with BNP, with reduced LV systolic function observed in both the low and high concentration range of BNP. CONCLUSIONS In healthy participants recruited from the general population, concentrations of BNP exhibit nonlinear associations with LV systolic function, and both low and high concentrations are associated with reduced LV systolic function. This supports the notion that natriuretic peptides are beneficial and elicit cardioprotective effects, and may have important implications for the interpretation of BNP measurements in the general population.
Using technology to assess nutritional status and optimize nutrition therapy in critically ill patients.

PURPOSE OF REVIEW Malnutrition is prevalent in critically ill patients and is linked to worse outcomes such as prolonged mechanical ventilation, length of intensive care unit (ICU) stay, and increased mortality. Therefore, nutritional therapy is important. However, it is often difficult to accurately identify those at high malnutrition risk and to optimize nutritional support. Different technological modalities have therefore been developed to identify patients at high nutritional risk and to guide nutritional support in an attempt to optimize outcomes. RECENT FINDINGS Computed tomography (CT), ultrasound (US), and bioelectrical impedance analysis are tools that allow assessment of lean body mass and detection of sarcopenia, which is a significant marker of poor nutrition. The use of indirect calorimetry allows the determination of resting energy expenditure to serve as a guide to providing optimal nutrition intake in ICU patients. SUMMARY By using CT, US, or bioelectrical impedance analysis, detection of sarcopenia can be undertaken in patients admitted to the ICU. This allows for an accurate picture of underlying nutritional status to help clinicians focus on nutritional support for these patients. Subsequently, indirect calorimetry can be used to guide optimal nutrition therapy and caloric intake in critically ill patients. However, whether these methods result in improved outcomes in critically ill patients remains to be validated.
Predictive value of radiological features on spread through air space in stage cIA lung adenocarcinoma

Background Spread through air space (STAS) is a risk factor for disease recurrence in patients with stage IA lung adenocarcinoma (LUAD) who undergo limited resection. Preoperative prediction of STAS could help intraoperative surgical decision-making in small LUAD patients. The aim of the study was to evaluate the predictive value of radiological features on STAS in stage cIA LUAD. Methods A case-control study was designed through retrospective analysis of the radiological features of patients who underwent curative surgery for LUAD with a clinical tumor size ≤3 cm. Univariable and multivariable analyses were used to identify the independent risk factors for STAS. The predicted probability of STAS was calculated by a specific formula. Receiver operating characteristic (ROC) curves were used to determine a cut-off value with appropriate specificity while maintaining high sensitivity for STAS positivity. Results STAS was frequently observed in acinar predominant (P<0.001), micropapillary predominant (P<0.001) and solid predominant (P<0.001) tumors and was significantly associated with larger pT size (P<0.001), presence of micropapillary component (P<0.001), lymphovascular invasion (LVI) (P<0.001), visceral pleura invasion (VPI) (P<0.001), both N1 and N2 lymph node metastasis (P<0.001) and ALK rearrangement (P<0.001). STAS-positivity was significantly associated with the presence of cavitation (P=0.047), lobulation (P=0.009), air bronchogram (P<0.001), and vascular convergence (P=0.016) and was also associated with greater maximum tumor diameter (P<0.001), maximum solid component diameter (P<0.001), maximum tumor area (P<0.001), consolidation/tumor ratio (CTR) (P<0.001), tumor disappearance ratio (TDR) (P<0.001) and computed tomography (CT) value (P<0.001). Multivariable analysis showed that STAS was associated with air bronchogram (P=0.042), maximum tumor diameter (P=0.015), maximum solid component diameter (P=0.022) and CTR (P<0.001). The ROC curve showed that the area under the curve (AUC) was 0.726 in the model for predicting STAS, with a sensitivity and specificity of 95.2% and 36.8%, respectively. Conclusions STAS-positive LUAD was associated with air bronchogram, maximum tumor diameter, maximum solid component diameter and CTR. These radiological features could predict STAS with excellent sensitivity but inferior specificity.
Six-year follow-up assessment of prosthesis survival and oral health-related quality of life in individuals with partial edentulism treated with three types of prosthodontic rehabilitation.

PURPOSE The purpose of the study was to compare the long-term performance of three prostheses for partial edentulism: implant-supported, fixed denture (IFD), fixed partial denture (FPD), and removable partial denture (RPD), in terms of prosthesis survival and oral health-related quality of life (OHRQoL). METHODS The 138 patients in our previous study (Kimura et al., 2012) received one of the three prosthetic treatments and answered a validated OHRQoL questionnaire before and immediately after treatment. In the present study, the patients were followed up six years after treatment using medical records and OHRQoL examinations to evaluate prosthesis survival and change in OHRQoL. The cumulative survival rates were calculated using the Kaplan-Meier analysis. The Steel-Dwass test was used to compare the median OHRQoL scores at the three time points. RESULTS For the 105 patients (66.8 ± 10.8 years, IFD/FPD/RPD: 58/27/20 patients) who successfully completed the follow-up assessments, the six-year estimated cumulative survival rates of the IFDs, FPDs, and RPDs were 94.7%, 77.4%, and 33.3%, respectively. The log-rank tests indicated that the survival curves were significantly different (IFDs vs. FPDs: p = 0.01; RPDs vs. IFDs, FPDs: p < 0.01). The median OHRQoL scores of the IFD group immediately after treatment and six years after treatment were significantly higher than those observed before treatment (p < 0.01). There was no significant difference in the median OHRQoL scores among the three time points in the RPD or FPD groups. CONCLUSIONS IFDs showed significantly longer survival rates than FPDs and RPDs in partially edentulous patients. Only in the IFD patients was the OHRQoL level six years after treatment significantly higher than that b efore treatment.