Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization and Evaluation

Purpose To prepare the supramolecular cocrystals of gliclazide (GL, a BCS class II drug molecule) via mechanochemical route, with the goal of improving physicochemical and biopharmaceutical properties. Methods Two cocrystals of GL with GRAS status coformers, sebacic acid (GL-SB; 1:1) and α-hydroxyacetic acid (GL-HA; 1:1) were screened out using liquid assisted grinding. The prepared cocrystals were characterized using thermal and analytical techniques followed by evaluation of antidiabetic activity and pharmacokinetic parameters. Results The generation of new, single and pure crystal forms was characterized by DSC and PXRD. The crystal structure determination from PXRD revealed the existence of both cocrystals in triclinic (P-1) crystal system. The hydrogen bonded network, determined by material studio was well supported by shifts in FTIR and SSNMR. Both the new solid forms displayed improved solubility, IDR, antidiabetic activity and pharmacokinetic parameters as compared to GL. Conclusions The improvement in these physicochemical and biopharmaceutical properties corroborated the fact that the supramolecular cocrystallization may be useful in the development of pharmaceutical crystalline materials with interesting network and properties.
THE ATTRACTIVENESS OF VOJVODINA PROVINCE AS A TOURIST DESTINATION ON THE BASIS OF DOMESTIC TOURISTS’ PERCEPTION

According to data of the Statistical Office of the Republic of Serbia, domestic tourists are very important segment of tourism market in the region of Vojvodina Province. In 2007, this segment represented 68.70% of whole tourist arrivals. But still, there is no tourism market research, that would be focused on domestic tourists’ perception of Vojvodina Province as a tourist destination. This study seeks to provide an assessment of the attractiveness of Vojvodina region based on the perception of domestic tourists and their evaluation of tourism offer. Also, behavioral intentions will be examined. The results of this research should show which elements of tourism offer in Vojvodina Province are the most attractive and could be “quick win” tourist products. Rezumat. Atractivitatea provinciei Voivodina ca destinaţie turistică pe baza percepţiei turiştilor interni. Conform datelor furnizate de Oficiul de Statistică al Republicii Serbia, turistii interni sunt un segment foarte important al pieţei turismului din provincia Voivodina. În 2007, acest segment a reprezentat 68.70% din ansamblul sosirilor turistice. Dar, totuşi, nu există nici o cercetare de piaţă a turismului, care să fie axată pe percepţia turiştilor din provincia Voivodina asupra acestei destinaţii turistice. Acest studiu urmăreşte să ofere o evaluare a atractivităţii din regiunea Voivodina pe baza percepţiei turistilor din piaţa internă şi a evaluării de către aceştia a ofertei turistice. De asemenea, vor fi examinate şi intenţiile comportamentale. Rezultatele acestei cercetări trebuie să indice care elemente ale ofertei turistice din provincia Voivodina sunt cele mai atractive şi care ar putea castiga rapid produse turistice.
Investigation on the Clusterability of Heterogeneous Dataset by Retaining the Scale of Variables

Clustering with heterogeneous variables in a dataset is no doubt a challenging process owing to different scales in a data. The paper introduced a SimMultiCorrData package in R to generate the artificial dataset for clustering. The construction of artificial dataset with various distribution helps to mimic the scenario of nature of real datasets. Our experiments shows that the clusterability of a dataset are influenced by various factors such as overlapping clusters, noise, sub-cluster, and unbalance objects within the clusters.
Using GPS Technologies with People with Dementia

In Norway and other Nordic countries, there is a policy emphasis on using welfare technologies to support people to live at home. For example, Global Positioning Systems (GPS) or ‘location technologies’ are used to support people with dementia and their next of kin with wayfinding. However, the research evidence has not been synthesised, and so the opportunities and challenges presented when using GPS technologies are not clear. This synthesising review examined all available empirical evidence on the use of GPS technologies by people with dementia and their family carers, through a critical disability lens – that is, in terms of protecting a person’s right to live in the community and taking the standpoint of the person with dementia (rather than a caregiver or health professional). Employing this lens meant that we engaged with the literature in a more critical way than standard reviews, and consciously looked for evidence of marginalisation. A search of six major English language databases in 2016 identified 23 studies that met the inclusion criteria. Synthesis of the findings led to the identification of three overarching themes: using GPS to stay safe, taking control and the value of GPS data for researchers. The review revealed a growing interest in the use of GPS technologies by people with dementia, which indicates that policy implementation is effective. Future work should take a disability-rights approach and focus on the value of using GPS technologies from the perspective of the person with dementia, as the opinions of this group are often overlooked in discussions about welfare technologies.
Metadata of the chapter that will be visualized in SpringerLink

We discuss in this paper a study of a smart and unobtrusive mattress in a clinical setting on a population with cardiorespiratory problems. Up to recently, the vast majority of studies with unobtrusive sensors are done with healthy populations. The unobtrusive monitoring of the Respiratory Rate (RR) is essential for proposing better diagnoses. Thus, new industrial and research activity on smart mattresses is targeting respiratory rate in an Internet-of-Things (IoT) context. In our work, we are interested in the performances of a microbend fiber optic sensor (FOS) mattress on 81 subjects admitted in the Cardiac Intensive Care Unit (CICU) by estimating the RR from their ballistocardiograms (BCG). Our study proposes a new RR estimator, based on harmonic plus noise models (HNM) and compares it with known estimators such as MODWT and CLIE. The goal is to examine, using a more representative and bigger dataset, the performances of these methods and of the smart mattress in general. Results of applying these three estimators on the BCG show that MODWT is more accurate with an average mean absolute error (MAE) of . However, the HNM estimator has space for improvements with estimation errors of . The smart mattress works well within a standard RR range of 10–20 breaths-per-minute (BPM) but gets less accurate with a bigger range of estimation. These results highlight the need to test these sensors in much more realistic contexts.
AANA Journal Course, AANA Journal, August 2019

Objectives At the completion of this course, the reader will be able to: 1. Describe the history of warfarin as an anticoagulant. 2. Compare and contrast warfarin with the modern oral anticoagulants. 3. Describe the sequencing of the coagulation cascade. 4. List effective monitoring strategies for dabigatran, rivaroxaban, apixaban, and edoxaban. 5. Discuss nonurgent and urgent reversal techniques for the most commonly prescribed oral anticoagulants.
Kinetics and characteristics studies on biosorption of Acid Red 18 from aqueous solution by the acid-treated mycelia pellets of Penicillium janthinellum

The biosorption of Acid Red 18 from aqueous solutions using nitric acid–treated mycelia pellets of Penicillium janthinellum as an adsorbent was studied in a batch system. The effect of solution pH, initial dye concentration, contact time and temperature on biosorption of the dye was carried out. The kinetic data of dye biosorption were analyzed by the pseudo first-order, pseudo second-order, intraparticle diffusion, external diffusion and Boyd models. The nitric acid–treated mycelia pellets of Penicillium janthinellum exhibited higher biosorption capacity than the native biomass. The biosorption capacity decreased with increasing pH from 2 to 10 and the maximum biosorption capacity for the dye was 46.45 mg g–1 at pH 3 at dye concentration of 50 mg L–1. The dye uptake of the acid-treated biomass increased with increasing the initial dye concentration in the studied concentration range. The kinetic process followed the pseudo second-order with higher correlation coefficients (R2 > 0.998). Based on kinetic models analysis, external diffusion and intraparticle diffusion played important roles in biosorption process and the biosorption rate of the whole biosorption process was mainly controlled by the external diffusion process. The Langmuir isotherm model could well describe the biosorption data. According to the thermodynamic analysis, the biosorption of AR 18 onto the fungal pellets was a spontaneous and endothermic process. The results suggest that the acid-treated mycelia pellets of Penicillium janthinellum can be used as an effective biosorbent to remove Acid Red 18 from aqueous solution.
Signed Reward Prediction Errors in the Ventral Striatum Drive Episodic Memory

Recent behavioral evidence implicates reward prediction errors (RPEs) as a key factor in the acquisition of episodic memory. Yet, important neural predictions related to the role of RPEs in episodic memory acquisition remain to be tested. Humans (both sexes) performed a novel variable-choice task where we experimentally manipulated RPEs and found support for key neural predictions with fMRI. Our results show that in line with previous behavioral observations, episodic memory accuracy increases with the magnitude of signed (i.e., better/worse-than-expected) RPEs (SRPEs). Neurally, we observe that SRPEs are encoded in the ventral striatum (VS). Crucially, we demonstrate through mediation analysis that activation in the VS mediates the experimental manipulation of SRPEs on episodic memory accuracy. In particular, SRPE-based responses in the VS (during learning) predict the strength of subsequent episodic memory (during recollection). Furthermore, functional connectivity between task-relevant processing areas (i.e., face-selective areas) and hippocampus and ventral striatum increased as a function of RPE value (during learning), suggesting a central role of these areas in episodic memory formation. Our results consolidate reinforcement learning theory and striatal RPEs as key factors subtending the formation of episodic memory. SIGNIFICANCE STATEMENT Recent behavioral research has shown that reward prediction errors (RPEs), a key concept of reinforcement learning theory, are crucial to the formation of episodic memories. In this study, we reveal the neural underpinnings of this process. Using fMRI, we show that signed RPEs (SRPEs) are encoded in the ventral striatum (VS), and crucially, that SRPE VS activity is responsible for the subsequent recollection accuracy of one-shot learned episodic memory associations.
Influential Persons In Online Social Networks By Preferential Attachment

: Identifying the person who influences all the other persons in the network is always an interesting phenomenon. Social networking connects the individuals and organizations over the globe. With the advent of online social networking sites, the individual can make their own network and be popularizing within the network is made easier nevertheless of considering the geographical location. Though there are numerous methodologies introduced to find such influential person(s) in the network, this research focused on social network analysis approach called preferential attachment to find such persons. It is considered as NP-hard problem, due to the reason that it is complex in structure. As a proof of concept, the proposed methodology is adopted over few exemplary datasets with variant in sizes. The results are showing that the proposed method is able to accommodate the different size of the dataset and finds the influencers nevertheless of considering its size.
Relationship between Serum C-reactive Protein Levels and Severity of Plasmodium falciparum Malaria in Children Seen in South-South Nigeria

Aim: To determine the relationship between serum C-reactive protein levels and severity of malaria infection in children aged six months to five years in a malaria endemic setting. Study Design: A prospective cross-sectional study. Place and Duration of Study: This study was carried out in the Children Out-patient (CHOP) Clinic, Children Emergency Unit (CHEU), Child Welfare/Growth Monitoring Clinic, Immunization Centre and main Paediatric Ward of the University of Uyo Teaching Hospital (UUTH), Uyo in Akwa-Ibom State. It was conducted over a six month period. Methodology: We studied three hundred and sixty (360) children with microscopically confirmed Plasmodium falciparum malaria and three hundred and sixty (360) healthy controls matched for age and gender. Their serum C-reactive protein levels were measured using the highly sensitive Enzyme Linked Immunosorbent assay (ELISA). Data analysis was done using the Statistical Package for Social Sciences (SPSS) version 17.0. Original Research Article International Journal of TROPICAL DISEASE & Health, 4(10): 1078-1087, 2014 1079 Results: The serum C-reactive protein levels showed a positive correlation with the malaria parasite count (r = 0.55; p < 0.001). Children presenting with severe manifestations of malaria had significantly higher mean serum C-reactive protein levels (33.3± 6.88mg/l) than the 8.12±9.09mg/l obtained in those with uncomplicated malaria (t = -15.57; p = 0.001. Conclusion: This study shows that C-reactive protein levels are increased in children with malaria, especially in severe malaria. Its estimation therefore holds potential usefulness as an adjunct for assessment of malarial severity.
The Burden of Mental Illness: An Emerging Global Disaster

The global burden of disease (GBD) has shifted from communicable to non-communicable diseases, and from premature death to years live with disabilities (YLDs) over the past 30 years. Mental and substance use disorders constitute a major component in the scenario of the global health with a significant impact on the global burden of disease, especially in the developing countries. The 1990 GBD study listed depression as the fourth common cause of global burden of disease; while lower respiratory infections, diarrheal diseases and conditions arising during perinatal period are top in the list. In GBD 2000 study depressive disorders climbed to the third place, however still behind lower respiratory infections and diarrheal diseases. The subsequent 2010 GBD study ranked depression in the second place of the global disability burden, and are also considered as a major contributor to the burden of suicide and ischaemic heart disease. The WHO predicted that depressive disorders will be the leading cause of global burden in 2030.
Cliffhanger-VR

The performance and security in outdoor climbing sports can depend on anxieties. These appear in frightening situations where, e.g. a deep fall is risked. Deep falls can lead to serious injuries or even to fatal accidents. Such situations can be trained in order to be mentally resistant to them and thereby to make climbing safer. However, drawbacks have to be taken into account. The trainee has to bring himself in a possible hazardous situation and nature is not directly reachable for every person. Thus, we present a system, where a user can climb at low heights in reality and simultaneously on a high cliff in VR. In this contribution, we describe the system architecture and future possibilities to safely train stressful outdoor climbing situations indoors.
Ever Young: A Big Game, Induced Pluripotent Stem Cell a Positive Candidate

Have you ever imagine that you will go to pharmacy to order cells instead of medicine. Yes scientists are trying to making it possible. Lots of trial has already been undertaken to make this scientific imagination true. People don’t want to be aged in course of life-time. Everybody wants to remain young. Induced pluripotent stem cells originate from somatic cell more specifically from patient specific somatic cell can be a possibility of this contemplation.
Colonización bacteriana pors mórtem del líquido cefalorraquídeo: Hospital de San José octubre 2007 - octubre 2008

As it is an imperative of the San Jose Hospital to determine the microorganism responsible for neuroinfection at the time of autopsy, it is necessary to carry out research that determines the prevalence and frequency of bacterial colonization; Likewise, it is important to identify Gram-positive and negative bacterial germs in patients who died at the institution. This cross-sectional study was conducted in hospitalized patients over 18 years of age who died in the Hospital of San Jose between October 1, 2007 and October 1, 2008, who met the inclusion and exclusion criteria. Transcisternal puncture and cerebrospinal fluid sample were taken with the authorization of the relatives and the standardized culture for Gram positive and negative aerobic germs was processed. The study was conducted with 25 patients who died at the Hospital of San Jose, of whom 28% showed growth in the CSF culture of isolated samples in a time shorter than thirteen hours post mortem (seven cases). Abbreviations: CSF, cerebrospinal fluid; CNS, central nervous system.
Using texture measures for visual quality assessment

In the last decade, many visual quality models have been proposed. However, there are some open questions involving the assessment of image and video quality. In the case of images, most of the proposed methods are very complex and require a reference content to estimate the quality, limiting their use in several multimedia application. For videos, the current state-of-the-art methods still perform worse than images in terms of prediction accuracy. In this work, we present an investigation of visual quality assessment methods based on texture measurements. The premise is that visual impairments alter image and video textures and their statistics. These measurements are performed regarding the statistics of the local binary pattern (LBP) operator and its extensions. We chosen LBP because it unifies traditional texture analysis models. In addition, LBP is a simple but effective algorithm that performs only fundamental operations, which favors fast and simple implementations, which is very useful for real-time image and video processing systems. Because of the abovementioned advantages, we analyzed the LBP operator and some of its state-of-the-art extensions addressing the problem of assessing image quality. Furthermore, we also propose new quality-aware LBP extensions to improve the prediction of quality. Then, we propose a framework for using these operators in order to produce new image quality metrics. Therefore, many no-reference image quality metrics can be generated from the proposed strategy. Inspired by experimental results of generated no-reference image quality metrics, we chosen a convenient texture operator to implement a full-reference video quality metric. In addition to the texture information, we also incorporate features including spatial activity, and temporal information. Experimental results indicated that our metric presents a superior performance when tested on several benchmark video quality databases, outperforming current state-of-the-art full-reference video quality metrics.
UmobiTalk: Ubiquitous Mobile Speech Based Learning Language Translator for Sesotho Language

The need to conserve the under-resourced languages is becoming more urgent as some of them are becoming extinct; natural language processing can be used to redress this. Currently, most initiatives around language processing technologies are focusing on western languages such as English and French, yet resources for such languages are already available. The Sesotho language is one of the under-resourced Bantu languages; it is mostly spoken in Free State province of South Africa and in Lesotho. Like other parts of South Africa, Free State has experienced high number of migrants and non-Sesotho speakers from neighboring provinces and countries; such people are faced with serious language barrier problems especially in the informal settlements where everyone tends to speak only Sesotho. Non-Sesotho speakers refers to the racial groups such as Xhosas, Zulus, Coloureds, Whites and more, in which Sesotho language is not their native language. As a solution to this, we developed a parallel corpus that has English as source and Sesotho as a target language and packaged it in UmobiTalk Ubiquitous mobile speech based learning translator. UmobiTalk is a mobile-based tool for learning Sesotho for English speakers. The development of this tool was based on the combination of automatic speech recognition, machine translation and speech synthesis. © Central University of Technology, Free State
Training for Landing and Cutting Stability in Young Female Basketball and Soccer Players

ABSTRACT ANTERIOR CRUCIATE LIGAMENT (ACL) INJURIES IN FEMALE ATHLETES OFTEN ARE NOT A RESULT OF PHYSICAL CONTACT, RATHER INJURIES TEND TO OCCUR DURING LANDING, CUTTING, OR PIVOTING TO CHANGE DIRECTION OR SPEED. FEMALE BASKETBALL AND SOCCER ATHLETES TEND TO EXHIBIT BIOMECHANICAL AND NEUROMUSCULAR PATTERNS DURING THESE MANEUVERS, WHICH CONTRIBUTE TO THEIR HIGHER INCIDENCE OF ACL INJURIES AMONG FEMALE AND MALE ATHLETES PARTICIPATING IN THE SAME SPORT. HOWEVER, INJURY PREVENTION PROGRAMS THAT INCORPORATE NEUROMUSCULAR, PLYOMETRIC, STRENGTH, AND BALANCE TRAINING HAVE BEEN BENEFICIAL IN REDUCING INJURY RISK FACTORS AND PROMOTING PROPER BIOMECHANICS TO PROMOTE KNEE STABILITY BY DECREASING STRESS ON THE ACL DURING THESE MANEUVERS.
Anesthesial management in the transcatheter closure of atrial septal defects in children)

SUMMARY Objective. To report the experience obtained in the anesthetic management during the transcatheter closure of inter-auricular com- munication (IAC) by means of the Amplatzer atrial septal occluder. Patients and methods. The observations were done in five children of 7 to 15 years age. Previous to the insertion of a transesoph- agic echocardiography transducer, inhalatory administration of sevoflurane and intravenous administration of midazolam/nalbuphine were performed. During the catheterization, sevoflurane was administered for anesthetic maintenance through the laryngeal mask. Results. In all patients, laryngeal mask and transducer were successfully inserted without any complication, induction was adminis- tered with sevoflurane by facial mask and intravenous administration of midazolam/nalbufina. At the time of occlusion of atrial inter- communication, one child had bradychardia (62 beats per min) that improved with higher fluxes of 100% O 2 . Anesthetic emersion occurred in 5 to 10 mm after discontinuation of sevoflurane. In all patients, echocardiographic transducer and laryngeal mask were removed without any complication. Conclusion. In despite that the experience was limited to five cases, laryngeal mask seems to be a good alternative to endotracheal tube for closure of inter-auricular communications with the Amplatzer device in pediatric patients.