Miracle-dz/UniFAR-FTUs huggingface dataset:
[Clinical analysis of orbital metastasis from nasopharyngeal carcinoma].

OBJECTIVE Metastasis of nasopharyngeal carcinoma (NPC) to the orbit has been rarely known. We report 11 patients with metastasis of NPC to the orbit and discuss their clinical characteristics and prognosis. METHODS Eleven patients with orbital metastasis of NPC who were seen between January 1, 1991 and December 31, 2003 in Zhongshan Ophthalmic Center, Sun Yat-sen University, were retrospectively reviewed. RESULTS Among 11 patients, there were nine males and two females. The mean age at diagnosis was 45.5 years. The left eye was involved in ten cases, and right eye in one. There were seven patients with a known history of NPC and four with no NPC history at the time of presentation. The seven patients with NPC history developed orbital metastasis at a mean time of 12.7 months (range 2.0 - 60.0 months) after the diagnosis of NPC. The mean duration of eye lesions at presentation was 10.3 months (range 0.7 - 36.0 months). Nine patients developed single metastatic focus and two patients had two foci in the affected orbit. The main component of the tumor was located in the nasal part of the orbit in eight cases, in the temporal part in two, and in the orbital apex in one. The anterior part of the orbit was affected in eight cases. The neoplasm was resected completely or partly through surgery. The diagnosis was histopathologically confirmed as NPC. Among them, four cases were squamous cell carcinomas, two cases lymphoepitheliomas, and five cases unclassified carcinomas. At the last following up examination, five patients had died as a result of disseminated metastasis, one patient had died of unknown cause and three were still alive with no active metastasis. Two patients had lost follow-up. The mean survival time after orbital diagnosis was 21 months. CONCLUSIONS NPC with orbital metastasis is rare. However, it is the most common primary cancer metastasizing to the orbit in our Center. Most of them were located in the anterior nasal part of the orbit. The prognosis of these metastasis cases is very poor.
Regulation of Organelle Membrane Fusion by Pkc1p

Membrane fusion relies on complex protein machineries, which act in sequence to catalyze the fusion of bilayers. The fusion of endoplasmic reticulum membranes requires the t‐SNARE Ufe1p, and the AAA ATPase p97/Cdc48p. While the mechanisms of membrane fusion events have begun to emerge, little is known about how this fusion process is regulated. We provide first evidence that endoplasmic reticulum membrane fusion in yeast is regulated by the action of protein kinase C. Specifically, Pkc1p kinase activity is needed to protect the fusion machinery from ubiquitin‐mediated degradation.
The Impacts of Tri Hita Karana - Based Educational Tourism

This study was aimed at analyzing and describing the impacts of Tri Hita Karana-Based Educational Tourism on the quality of the community life. This descriptive qualitative research was done to the communities of Mengesta Village. The subjects consisted of 60 community members involved as the learning resource persons in developing the educational tourism. The data which were collected consisted of the impact of the development of educational tourism on the improvement of the community life quality. The data were collected by using questionnaire and field observation. The data was analyzed descriptively and qualitatively. The result showed that the average of the respondents’ responses related to the impact of the development of the educational tourism on the social community life was 88%, falling into “positive” minimal qualification. There was an increase in the local economy with the average of 55%. Keywords—educational tourism, Tri Hita Karana, quality of community life
Decision Comprehensiveness and Corporate Entrepreneurship: The Moderating Role of Managerial Uncertainty Preferences and Environmental Dynamism

Although comprehensiveness is considered among the most salient and enduring strategic decision-making characteristics in organizations, its influence on firm behaviour has remained elusive. As a first step, our study builds and tests a model that specifies the influence of comprehensiveness on the firm's pursuit of corporate entrepreneurship. Our core argument is that while comprehensiveness helps decision-makers gain the knowledge needed to escape the ignorance and overcome doubt associated with this pursuit, this beneficial influence is conditional upon managerial uncertainty preferences, together with the level of dynamism in the external environment. Findings from a large sample study of CEOs from 349 SMEs provide general support for this argument and associated hypotheses.
Subcortical projections of six visual cortical areas in the owl monkey, Aotus trivirgatus

Subcortical projections of six visual cortical areas (Areas 17 and 18, the Middle Temporal, Dorsomedial and Medial Areas, and the Posterior Parietal Region) in the owl monkey, Aotus trivirgatus, were investigated with autoradiographic methods following injections of tritiated proline. No contralateral projections were demonstrated. While some brainstem structures received input from all six subdivisions of cortex, each cortical area appeared to exhibit its own unique pattern of subcortical projections. All six cortical areas were found to project to the superior and inferior divisions of the pulvinar, reticular nucleus of the thalamus, pretectum and superior colliculus. Other subcortical targets of one or more visual cortical areas were the basal ganglia, claustrum, zona incerta, one or more of the intralaminar nuclei, lateral posterior nucleus, pregeniculate nucleus, dorsal lateral geniculate nucleus, and pontine nuclei. Furthermore, details of corticofugal projections to the dorsal lateral geniculate nucleus, pretectum and superior colliculus varied with the cortical area studied. The projections to the reticular nucleus, pregeniculate nucleus, dorsal lateral geniculate nucleus, the inferior and a portion of the superior division of the pulvinar and the superior colliculus were found to be topographically organized. The targets of the subcortical projections were compared with those of the retina, as revealed by autoradiographic methods following tritiated proline injections of the eye and were found to overlap to varying extents in the superior colliculus, pretectum and dorsal lateral geniculate nucleus and to be segregated in the pregeniculate nucleus. The results substantiate the validity of previous studies in the owl monkey that suggest that the visual cortex is subdivided into several functionally distinct areas and illustrate the complexity of corticofugal influence on visual processing.
PTSD and Substance Use: Unrecognized Sequelae of Bioterrorism in Primary Care Providers

Background: Psychological casualties following public health emergencies are likely to significantly outnumber physical casualties. However, postevent psychological disorders may be under-recognized by primary care providers (PCPs). Methods: Rural PCPs in northern and central Florida were interviewed using a series of open-ended questions to assess knowledge of likely mental disorders, their risk factors, and preferred treatment options following such events (n = 21). Results: PTSD was identified by 14% and substance abuse by 10% of the sample. Physicians were significantly more likely to identify posttraumatic stress disorder (PTSD) as an expected postevent psychological disorder than nonphysician providers. PCPs were significantly more likely to endorse counseling (86%) than medications (43%) as a preferred treatment option. Conclusions: Our findings support the need for increased education and training regarding the mental health consequences of bioterrorism in rural PCPs, particularly for nursing-level and other nonphysician providers. Improvements in knowledge may enhance preparedness for such emergencies.
Neonatal intensive care utilization and neonatal outcome of infants born to women aged 40 years and over in New Zealand

Background: Increased maternal age is associated with pregnancy complications and there are few data available on neonatal outcome and utilization of neonatal resources. Our first aim was to use national New Zealand data to determine if the outcomes following admission to NICU are different for infants born to women aged 40 years and over, compared with those born to women under 40 years of age. The second aim was to document trends in the requirement of neonatal intensive care in infants born to women aged 40 years and older.
E-Commerce Readiness of SMEs in Developing Countires: A Model-Driven Systematic Literature Review

It is important that modern IS decision making is accomplished using a systematic evaluation of research. A Model Driven Systematic Literature Review (MD-SLR) was used to examine the factors that influence e-commerce adoption readiness of Small and Medium Enterprises (SMEs) in developing countries. An initial review of commonly used theories of e-commerce adoption and e-readiness assessment theories was conducted to provide the model driving the MD-SLR. During the MD-SLR evidence was sought from all relevant empirical qualitative studies identified to refine the initial model based on evidence. The evidence supported the existence of internal SME factors (such as: awareness, commitment, technological resources, size of organisation, business resources, social relationship, relational complexities and human resources) and external factors (such as government readiness, market forces, supporting industries). New factors emerged: power supply instability, social and relationships, family support, political uncertainty, and cultural issues.
Editorial: Statins and Tissue Plasminogen Activator for Stroke: A Beneficial Combination?

Department of Neurology, “Annunziata” Hospital”, Cosenza, Italy; Department of Neurology, Madonna del Soccorso Hospital, S Benedetto del Tronto, Italy; Department of Neurology, General Hospital Tappeiner, Merano (Bolzano), Italy; Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Catanzaro, Italy; Department of Neurology, Santa Maria Nuova Hospital, Reggio Emilia, Italy
Basic logic

This book is at treat. The logic community should thank Miloš Adžić and the late Kosta Došen for their huge effort in editing Gödel’s lecture notes of his 1939 Basic Logic Course at Notre Dame. Adžić and Došen have turned a number of handwritten notebooks that served as the basis of Gödel’s course into—even by modern standards—an elegant logic textbook, which is a pleasure to read. The edited lecture notes highlight once again what a clear and lucid thinker Gödel was. The book consists of an editorial introduction in which the editorial decisions and the notational conventions are explained, the edited text of Gödel’s logic course, and the source text in printed form. The source text provides a good idea of the amount of work that has gone into the editing process. Gödel’s notes are full of abbreviations, a number of passages are crossed out and every now and then there are interludes in which Gödel is concerned with seemingly unrelated issues—for example religious questions. The material covered by Gödel consists of a thorough discussion of propositional logic, an introduction to first-order logic and to basic notions of the calculus of classes. The lecture notes end with a short discussion of Russell’s paradox and the theory of types. In this review I shall start by briefly commenting on the editorial introduction and a number of Adžić and Došen’s editorial decisions. I then provide a brief summary and discussion of the content of Gödel’s Basic Logic Course. Before I start I would like to point the interested reader to the work of Adžić and Došen (2016) and Cassou-Nogues (2009). These works provide an outline of the content of the Gödel’s Notre Dame lectures and comment on their philosophical and historical significance.
Heterarchia jako źródło konfliktów organizacyjnych – perspektywa kierowników i nie kierowników / Heterarchy as a source of organizational conflicts – managers’ and non-managers’ perspective.

Studies on organizational conflict show its various sources, including personal characteristics of team members, differences of values and norms, team life cycle, organizational paradoxes and tensions, inadequate communication, etc., but not too much attention is paid to organizational structure as a source of conflicts in an organization. The paper examines the influence of heterarchy on organizational conflicts. Basing on survey conducted on a group of managers (n=224) and non-managers (146) two different perspectives of heterarchy and its implications were shown. The study shows that more intensive heterarchy the more frequent, intensive and destructive conflicts, but this conclusion we draw only on the basis of the results of non-managers’ group. The results obtained in a group of managers do not show the same correlation, and the managers generally see heterarchy mostly in terms of its advantages.
A COMPARISON OF TRAPS AND STEM TAP SAMPLING FOR MONITORING ADULT ASIAN CITRUS PSYLLID (HEMIPTERA: PSYLLIDAE) IN CITRUS

Abstract Studies were conducted at 2 different field sites to compare yellow sticky card traps, blue sticky card traps, Multi-Lure traps, and CC traps (red, blue, black, white, yellow, and dark green bases) for monitoring adult Asian citrus psyllid, Diaphorina citri Kuwayama, in citrus. The Multi-Lure and CC traps were charged with either ethylene glycol or a dichlorvos kill strip to kill psyllids entering the trap. We also investigated a stem tapping method for monitoring adult D. citri. Yellow sticky card traps captured significantly more adults than blue sticky card traps over a 4-week period in one study but not the other. Over all sample weeks, each of these traps captured significantly greater numbers of adults than any of the other traps. Yellow and blue sticky traps were equally effective in detecting the presence of adults in trees given the infestation levels present at the 2 study sites. The CC and Multi-Lure traps captured so few adult psyllids and provided such poor detection of trees infested by adults that they appeared to have no value for monitoring D. citri. Tap sampling was easy to conduct and provided relatively good detection of trees infested by adults given the infestation levels present at the 2 groves. An advantage to stem tap sampling over sticky trap sampling is that tap sampling provides information on the presence and relative abundance of adult D. citri during a single visit to a block of trees while sticky trap sampling requires 2 visits. Research to develop standard protocols for sticky trap and stem tap sampling for adult D. citri in citrus would be advantageous.
Origin And Development of Auditing

The investing public has historically relied upon audited financial statements when making investment decisions and has depended upon auditors and the accounting profession to confirm the accuracy and completeness of financial information. Auditing evolved and grew rapidly after the industrial revolution in the 18 th century with the growth of the joint stock companies where the ownership and management became separate. The audit function was mainly to provide credibility to the financial statements prepared by company managers for their shareholders. Consensus was generally achieved that the primary objective of an audit function is adding credibility to the financial statements rather than on the detection of fraud and errors.
We've Come a Long Way Baby

WHEN KRISTINA GENOVY turned 18 months old, her parents gathered family and friends together for a joyous dinner to celebrate, laugh and have a good cry. Because her mother, Anne, is HIV+, Kristina had to take three HIV tests after she was born to make sure she didn’t get the virus from her mom. The first two came back negative, but the third, administered at 18 months, was the defining result. Like the other tests, this one came back negative, proving the good news: Kristina was positively, no question, HIV negative.
Inter-organizational relationships : the evolution of partnership governance in sales and marketing cooperation : a case study

The dissertation is a case study on how the governance of the sales and marketing partnership between a telecommunications services provider and an information technology equipment supplier evolved during a two-year research period. The research is based on rich process data collected alongside operational, practical day-to-day operations, and on thematic interviews from both partnering organizations. The research data is organized into a case narrative, which is used in interpreting the events and development of the partnership governance as structure and management through four theoretical lenses. The research design is based on Alternate Templates Strategy (ATS) and the theories used are Theory of the Growth of the Firm, Resource Based View, Transaction Costs Economics and Stakeholder Theory. The theories are refined into theoretical lenses by forming distinct batteries of research questions that are systematically, one-by-one, applied in the analysis of the case narrative. Based on established interpretations and their combination, the final stage of the research process is generalization of the case-dependent argumentations into propositions. The study provides understanding of partnership governance processes that affect the partnership performance and outcomes, as well as impact both the premises for and the development of the partnership. New insights to identifying and managing partnership’s stakeholders; setting of joint, measurable goals; legitimateness building activities; sensemaking and communication of the partnership in relation to the partners’ common history and current strategies or operations; as well as structuring the cooperation and facilitation of interactions between people, contribute to extant IOR literature. In addition, recommendations for partner managers provide suggestions for partnership governance in practice. Moreover, the study contributes to the development of the ATS as a systematic process research approach and method.
Plasmodium falciparum carbohydrate metabolism: a connection between host cell and parasite.

Selected aspects of the metabolism of Plasmodium falciparum are reviewed, but conclusions based on the study of other species of plasmodia are intentionally not included since these may not be applicable. The parasites increase glucose consumption 50-100 fold as compared to uninfected red cells; most of the glucose is metabolized to lactic acid. The parasite contains a complete set of glycolytic enzymes. Some enzymes such a hexokinase, enolase and pyruvate kinase are vastly increased over corresponding levels in uninfected red cells. However, the pathway for synthesizing 2,3-diphosphoglycerate (2,3-DPG) is absent. Parasitized red cells show a decline in the concentration of 2,3-DPG which may function as an inhibitor for certain essential enzyme pathways. Pentose shunt activity is increased in absolute terms, but as a percent of total glucose consumption, there is a decrease during parasite infection of the red cell. The parasite contains a gene for G6PD and can produce a small quantity of parasite-encoded enzyme. It is not clear if the production of this enzyme can be up-regulated in G6PG deficient host red cells. The NADPH normally produced by the pentose shunt can be obtained from other parasite pathways (such as glutamate dehydrogenase). NADPH may subserve additional needs in the infected red cell such as driving diribonucleotide reductase activity--a rate limiting enzyme in DNA synthesis. The role of NADPH in protecting the parasite-red cell system against oxidative stress (via glutathione reduction) remains controversial. Parasitized red cells contain about 10 times more NAD(H) than uninfected red cells, but the NADP(H) content is unchanged. (ABSTRACT TRUNCATED AT 250 WORDS)
Evaluation of an interprofessional practice placement in a UK in-patient palliative care unit

This paper reports on undergraduate students’ evaluation of a new hospice-based interprofessional practice placement (IPP) that took place in the voluntary sector from 2008 to 2009. Ward-based interprofessional training has been successfully demonstrated in a range of clinical environments. However, the multidisciplinary setting within a hospice in-patient unit offered a new opportunity for interprofessional learning. The development and delivery of the IPP initiative is described, whereby multidisciplinary groups of 12 students provided hands-on care for a selected group of patients, under the supervision of trained health care professionals. The placement was positively evaluated and students reported an increased understanding of both their own role and that of other professionals in the team. The evaluation also suggests that additional learning opportunities were provided by the in-patient palliative care unit. The results of this evaluation suggest that the in-patient unit of a hospice caring for patients with life-limiting illness provides a suitable environment to demonstrate and learn about interprofessional practice.
Advances in Brief Overexpression of the Focal Adhesion Kinase ( p 125 @ K ) in Invasive Human Tumors '

The focal adhesion kinase (FAK) gene encodes a tyrosine Manse (p1@5FAK) thought to be involved in signal transduction pathways used in cell adhesion, motility, and anchorage-independent growth. Because al terations In these cellular processes occur in tumor invasion and metas tasis, we studied the protein expression of FAK in a variety of human tumors and found that in the 119 samples studied, increased levels of p173FAK correlated with the invasive potential of a tumor. By comparing FAK expression in tumors with normal tissue from the same patient, we found that p1@,5FAKwas significantly elevated in 17 (100%) of 17 invasIve and metastatic colonic lesions and in 22 (88%) of 25 invasive and mete static breast tumors. Additional studies of FAK expression in 13 high grade sarcomas showed high levels in all samples compared to benign, noninvasive mesenchymal specimens. Furthermore, FAK protein levels were elevated in preinvasive lesions, such as large (>2 cm) colonic villous adenomas, whereas noninvasive, yet hypercellular, neoplastic tissues such as parathyroid and hepatocellular adenomas did not overexpress FAK. These data provide evidence that both epithellal and mesenchymal tumor progression are accompanied by increased p125'@'@â€• expression and sug gest that the level of FAK expression might be a marker for the invasive potential of a tumor.