Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term management of atopic dermatitis in infants with topical pimecrolimus, a nonsteroid anti-inflammatory drug.

BACKGROUND Pimecrolimus cream 1% (Elidel, SDZ ASM 981), a nonsteroid selective inhibitor of inflammatory cytokines, is effective in the treatment of atopic dermatitis (AD). In this study we compared early intervention with pimecrolimus cream with treatment with a vehicle control. OBJECTIVE The purpose of this investigation was to assess whether early treatment in infants of AD signs/symptoms with pimecrolimus could influence long-term outcome by preventing disease flares. METHODS In this 1-year, double-blind controlled study, 251 infants aged 3 to 23 months with AD were randomized 4:1 to a pimecrolimus-based regimen (n = 204) or a conventional treatment regimen (n = 47). Both groups used emollients for dry skin. Early AD signs and symptoms were treated either with pimecrolimus cream to prevent flares or, in the control group, with vehicle. Vehicle was used to maintain blinding conditions. In the event of flares, moderately potent corticosteroid was permitted in both groups. The primary efficacy end point was the incidence of flares at 6 months. RESULTS Pimecrolimus significantly reduced the incidence of flares compared with control treatment (P <.001), with 67.6% versus 30.4% of patients completing 6 months with no flare and 56.9% versus 28.3% completing 12 months with no flare. Overall corticosteroid use was substantially lower in the pimecrolimus group: 63.7% versus 34.8% of patients did not use corticosteroids at all during the study. Pimecrolimus was also more effective than control treatment in the long-term control of pruritus and the signs of AD. There were no clinically significant differences in incidence of adverse events between the 2 treatment groups. CONCLUSIONS Treatment with pimecrolimus of early signs and symptoms significantly modified the disease course in infants by reducing the incidence of flares and improving overall control of AD. Pimecrolimus was safe and well tolerated.
Clopidogrel and Side Effects

Clopidogrel is a recently developed thrombocyte inhibitor with fewer side effects. We report 2 patients with purpura and thrombopenia, respectively, due to clopidogrel therapy. As this compound is widely used in clinical practice, the occurrence of hematological and dermal side effects should be considered.
Frequency of Gamma Activity is Modulated by Motivation in the Auditory Cortex of Cat

Repetitive acoustic stimuli elicit steady-state response (SSR) in the gamma-band both in humans and in mammals. Our aim was to investigate changes of the spontaneous gamma activity and the SSR in the auditory cortex of cats in the background of an instrumental conditioning situation. Epidural electrodes were chronically implanted above the auditory neocortex. The presentation rate of the clicks varied between 20 and 65/s. Spontaneous EEG and SSR were collected in three behavioral states: in an indifferent environment, in the instrumental cage while the cat was waiting for the light CS, and when she stepped on the pedal and was waiting for the meat reward. Using different repetition rate clicks we determined which stimulus rate elicited the largest SSR in these three situations. In quiet animal the highest SSR appeared at 28–30/s. Before and during the CS the optimal stimulus rate shifted to 32–38/s. The frequency of the spontaneous gamma activity changed in parallel way depending on the situation. We conclude that both the SSR and the spontaneous gamma activity reflect resonant activity of the same neuronal circuit of the auditory cortex, and it is modulated by the motivational state of the animal.
Glycine Residues Provide Flexibility for Enzyme Active Sites*

The high resolution refined structures of 23 enzymes were analyzed to determine the properties of amino acids involved in active site regions. These regions were found to be rich in G-X-Y or Y-X-G oligopeptides, where X and Y are polar and non-polar residues, respectively, that are small and with low polarity. Other regions of the enzyme molecules have significantly fewer of these sequences. These features suggest that glycine residues may provide flexibility necessary for enzyme active sites to change conformation, and the G-X-Y or Y-X-G oligopeptides may be a motif for the formation of enzyme active sites.
PREANALYTICAL CONSIDERATIONS IN DRUG ASSAYS IN CLINICAL PHARMACOKINETIC STUDIES

Many hospital pharmacy laboratories undertake drug analysis in biological fluids for the production of pharmacokinetic data. The success of such an undertaking very much depends on the selection of a suitable analytical method and a proper approach to sample collection and handling. This paper surveys the main types of biological specimens taken from the patients for pharmacokinetic drug analysis and discusses factors that affect them during or subsequent to their removal. Guidelines are provided in specimen handling and dealing with many problems which could arise prior to actual analysis. By its very nature this paper brings in many disciplines, the full details of which are well beyond its scope, however, some discussion on pharmacokinetic and bioavailability methods in relation to sampling procedures is included to put the matter into a proper perspective.
Controlled Propagation of Spiking Dynamics in Vertical-Cavity Surface-Emitting Lasers: Towards Neuromorphic Photonic Networks

We report experimentally and in theory on the controllable propagation of spiking regimes between two interlinked vertical-cavity surface-emitting lasers (VCSELs). We show that spiking patterns generated in a first transmitter VCSEL (T-VCSEL) are communicated to a second receiver VCSEL (R-VCSEL), which responds by firing the same spiking response. Importantly, the spiking regimes from both devices had analogous temporal and amplitude characteristics, including equal number of spikes fired, same spike and interspike temporal durations, and similar spike intensity properties. These responses are analogous to the spiking communication patterns of biological neurons yet at subnanosecond speeds, this is several (up to 8) orders of magnitude faster than the timescales of biological neurons. We have also carried out numerical simulations reproducing with high degree of agreement the experimental findings. These results obtained with inexpensive, commercially available VCSELs operating at important telecom wavelengths (1300 nm) offer great prospects for the scaling of emerging VCSEL-based photonic neuronal models into network configurations for use in novel neuromorphic photonic systems. This offers high potentials for nontraditional computing paradigms beyond digital systems and able to operate at ultrafast speeds.
An industrial research on GUI testing techniques for windows based application using UFT

Every software in modern world consists of Graphic user interface (GUI) through which it interacts with the user. The GUI is one of the most important aspects of software because it gives flexibility to software and provides ease to communicate with it. As most of the modern day's software uses GUI as its front end to communicate with the user, GUI testing [1] is considered as a critical part in any software industry. GUI testing not only has to do in software build, but it has to be done rigorously after each revision or after adding/removing any features to it [2]. This type of testing cannot be performed thoroughly as it is very time consuming and tedious work which affects cost and time for any industry. And even it is done one cannot simply depend upon result as most of the time developers are different than testers so the results are unreliable and may contain human errors. So the GUI automation testing techniques came into existence. Automated scripts are developed using GUI automation tools like UFT (QTP), TestComplete, Ranorex etc. to check GUI functionality so after creating scripts manual work is avoided. GUI testing software has developed lots of technique to test software functionality which are based on java, oracle, Delphi, WPF, Web etc., but software which is detected as windows based by the automation tool doesnt have much of methods and techniques to test as they may base on VC++ platform. This paper gives techniques to generate automated test script for windows based applications. These techniques include moving text recognition, Vertical text recognition, Import/Export in excel, simplified result techniques, SQL with datatable etc. These techniques will make very easy to automate windows based application as well as other platform application as some of the technique can use for all types of platforms. In this paper different automation tools are used to developed techniques, but major work is shown in Unified Functional Testing (UFT) previously known as Quick Test Professional (QTP). Two softwares are use for testing purpose which are based on VC++ and wpf respectively.
Estrogen receptors and breast cancer response to adrenalectomy.

Results of studies of receptor content of dependent rat mammary tumors suggested that an estimation of the receptor content of a breast cancer specimen might provide a valuable guide for predicting the response of that patient to ablative therapy. This investigation was undertaken both by patients with metastatic disease to correlate their response to adrenalectomy or hypophysectomy and of mastectomy patients to characterize the primary tumor for further correlation with the response to endocrine therapy should the cancer recur. Tumors were obtained as soon as possible after excision. Techniques methods and materials employed are given in detail. When slices of tumor were examined for estradiol affinity by the uptake-inhibition procedure they were found to fall into 2 classes: 1) those showing low uptake not depressed in the presence of nafoxidine or Parke-Davis CI-628 and 2) those showing a larger incorporation which was reduced by the inhibitor. A few showed a borderline pattern. Metastatic tumors presented similar patterns to primary tumors. Positive metastatic tumors usually showed a higher total level of estradiol incorporation than positive primary tumors. Based on the results of 51 mastectomy patients divided equally between positive and negative patterns with 2 borderline cases it is concluded that patients whose breast cancers lack the estrogen receptor substance have little chance of responding to endocrine therapy or ablative surgery. Some of those who possess estrogen-binding proteins will benefit from such treatment. It is possible that those with positive findings may have mixed metastases so that the negative metastases will be unresponsive. False positive reactions may lead to futile treatment but false negative readings may cause omission of treatment that could lead to remissions. Subsequent to the original study additional patients have been added. Of a total of 84 primary tumors 39 showed the presence of an estrogen receptor 38 were negative and 7 were borderline. Of 40 metastatic tumors 12 were positive 25 negative 2 borderline and 1 with multiple metastases showed both positive and negative in different specimens. Of 58 patients with metastatic disease 42 had received some type of endocrine therapy. However 10 of 13 patients whose cancers contained estrogen receptors showed remission with endocrine therapy.
Ubiquitous Recommendation Systems

In many popular visions of ubiquitous computing, the environment proactively responds to individuals who inhabit the space. For example, a display magically presents a personalized advertisement, the most relevant video feed, or the desired page from a secret government document. Such capability requires more than an abundance of networked displays, devices, and sensors; it relies implicitly on recommendation systems that either directly serve the end user or provide critical services to some other application. As recommendation systems evolve to exploit new advances in ubiquitous computing technology, researchers and practitioners from technical and social science disciplines must collaborate to address the challenges to their effective implementation. Although it may be impossible to perfectly anticipate each individual's needs at any place or time, ubiquitous computing will enable such systems to help people cope with an expanding array of choices.
On the impact of TiN film thickness variations on the effective work function of poly-Si/TiN/SiO/sub 2/ and poly-Si/TiN/HfSiON gate stacks

The impact of TiN film thickness variations on the effective work function (WF) of poly-Si/TiN/SiO/sub 2/ and poly-Si/TiN/HfSiON interfaces has been investigated. The electrical signatures of these gate stacks indicate that the concentration of Hf-Ti and Ti-Si bonds at the (poly-Si/TiN)/HfSiON and (poly-Si/TiN)/SiO/sub 2/ interface plays a significant role on the control of the gate stacks' WF. The density of these interfacial bonds and the related work function changes are correlated to the degree of nucleation of the TiN film on the dielectric.
Maturation pathway of nisin and other lantibiotics: post‐translationally modified antimicrobial peptides exported by Gram‐positive bacteria

Lantibiotics form a family of highly modified peptides which are secreted by several Gram‐positive bacteria. They exhibit antimicrobial activity, mainly against other Gram‐positive bacteria, by forming pores in the cellular membrane. These antimicrobial peptides are ribosomally synthesized and contain leader peptides which do not show the characteristics of signal sequences. Several amino acid residues of the precursor lantibiotic are enzymatically modified, whereafter secretion and processing of the leader peptide takes place, yielding the active antimicrobial substance. For several lantibiotics the gene clusters encoding biosynthetic enzymes, translocator proteins, self‐protection proteins, processing enzymes and regulatory proteins have been identified. This MicroReview describes the current knowledge about the biosynthetic, immunity and regulatory processes leading to lantibiotic production. Most of the attention is focused on the lantibiotic nisin, which is produced by the food‐grade bacterium Lactococcus lactis and is widely used as a preservative in the food industry.
Familial Association of Hypoplasminogenemia and Heterozygous Factor V Deficiency

The coinheritance of hypoplasminogenemia and heterozygous factor V deficiency in a relative with thrombotic disease and no hemorrhagic tendency is described. The proposita, a 28-year-old woman, suffered from neurologic dis turbances due to two ischemic cerebral lesions confirmed by nuclear magnetic resonance scan. She was found to be affected with heterozygous plasminogen deficiency in a coagulation study for inherited thrombophilia. Moreover, she disclosed a prolongation of prothrombin time and activated partial throm boplastin time, which was compatible with heterozygous factor V deficiency. Her father, with a history of deep vein thrombo sis, was also affected with plasminogen deficiency, as well as three brothers and one sister who were asymptomatic. The mother of the proposita showed borderline or slightly decreased factor V levels and normal plasminogen levels; she was there fore considered to be heterozygous for factor V deficiency. Heterozygous factor V deficiency was also found in one brother and one sister of the proposita, and they were both asymptomatic. Among the other available family members, one brother and one sister of the proposita, all asymptomatic for either thrombotic or bleeding events, showed a normal clotting and fibrinolytic profile. To our knowledge, this is the first case of combined heterozygous plasminogen and factor V defi ciency in the same family. Two of six patients with hypoplas minogenemia showed thrombotic events, and in one of these symptomatic cases the coexistence of factor V deficiency did not prevent the occurrence of thrombosis. As expected, no hemorrhagic tendency was observed in patients with heterozy gous factor V deficiency, who may be mildly symptomatic only in 10% of cases.
Arsenic-Induced Decreases in the Vascular Matrix

Chronic ingestion of arsenic is associated with increased incidence of respiratory and cardiovascular diseases. To investigate the role of arsenic in early events in vascular pathology, C57BL/6 mice ingested drinking water with or without 50 ppb sodium arsenite (AsIII) for four, five, or eight weeks. At five and eight weeks, RNA from the lungs of control and AsIII-exposed animals was processed for microarray. Sixty-five genes were significantly and differentially expressed. Differential expression of extracellular matrix (ECM) gene transcripts was particularly compelling, as 91% of genes in this category, including elastin and collagen, were significantly decreased. In additional experiments, real-time RT-PCR showed an AsIII-induced decrease in many of these ECM gene transcripts in the heart and NIH3T3 fibroblast cells. Histological stains for collagen and elastin show a distinct disruption in the ECM surrounding small arteries in the heart and lung of AsIII-exposed mice. Immunohistochemical detection of α-smooth muscle actin in blood vessel walls was decreased in the AsIII-exposed animals. These data reveal a functional link between AsIII exposure and disruption in the vascular ECM. These AsIII-induced early pathological events may predispose humans to respiratory and cardiovascular diseases linked to chronic low-dose AsIII exposure.
Research on the health effects of retirement: an uncertain legacy.

The contention that retirement may have an adverse effect on health has become increasingly popular with the recent categorization of this phenomenon as a stressful "life event. " The small number of empirical studies examining the health outcomes of retirement, however, appear neither to support nor to refute this hypothesis. Moreover, the serious methodological problems inherent in most of these studies caution against the generalization of findings. This paper examines the existing research on the health and retirement relationship within the theoretical context of Atchley's process approach to retirement. Recent refinements in the study of life events (e.g., a focus on the timing of the event and the degree of control experienced) are seen as offering important potential contributions both to our understanding of retirement and to the development of more incisive and conceptually sound research in this area. At the same time, the inadequacy of existing life-events scales when applied to an older age group, and the generalfailure to view life changes within a broad sociostructural context are emphasized as weaknesses of the life-events approach that should be taken into account in future research on the complex retirement and health relationship.
Australia's net exports and the Australian Dollar effective exchange rate

This paper examines potential determinants of Australia’s net exports over the period 1960(1) to 1998(4) using ARDL cointegration procedures. The private savings-investment gap, OECD economic activity and Australia’s price level relative to that in the OECD were found to have had long-run impacts on net exports. Additionally, Australia’s terms of trade exerted a short-run influence. The government budget deficit appeared to have no influence whatsoever. Estimation of a similar equation for the period after the floating of the Australian dollar (AUD) in December 1983 indicates that only OECD GDP and the private savings-investment gap had a (reduced) impact in this period. Since the float, movements in the AUD effective exchange rate appear to have insulated net exports wholly or partly from changes in relative price levels, the terms of trade, domestic economic activity and the private savings-investment gap. These conjectures are supported by estimates of an equation for the nominal effective value of the AUD.
A Hybrid Multi-Criteria Hotel Recommender System Using Explicit and Implicit Feedbacks

 Abstract — Recommender systems, also known as recommender engines, have become an important research area and are now being applied in various fields. In addition, the techniques behind the recommender systems have been improved over the time. In general, such systems help users to find their required products or services (e.g. books, music) through analyzing and aggregating other users’ activities and behavior, mainly in form of reviews, and making the best recommendations. The recommendations can facilitate user’s decision making process. Despite the wide literature on the topic, using multiple data sources of different types as the input has not been widely studied. Recommender systems can benefit from the high availability of digital data to collect the input data of different types which implicitly or explicitly help the system to improve its accuracy. Moreover, most of the existing research in this area is based on single rating measures in which a single rating is used to link users to items. This paper proposes a highly accurate hotel recommender system, implemented in various layers. Using multi-aspect rating system and benefitting from large-scale data of different types, the recommender system suggests hotels that are personalized and tailored for the given user. The system employs natural language processing and topic modelling techniques to assess the sentiment of the users’ reviews and extract implicit features. The entire recommender engine contains multiple sub-systems, namely users clustering, matrix factorization module, and hybrid recommender system. Each sub-system contributes to the final composite set of recommendations through covering a specific aspect of the problem. The accuracy of the proposed recommender system has been tested intensively where the results confirm the high performance of the system.