Miracle-dz/UniFAR-FTUs huggingface dataset:
FPGA-Oberon - Design and Implementation of a System Description Language based on the Oberon language

FPGAs provide a massively parallel architecture that has large possibilities for speeding up tasks that need lots of data processing power; however, the tools normally used to build the software for those platforms are hard to master, and create unnecessarily complex and specific systems. A relatively new design methodology for FPGAs is to use traditional programming languages to develop programs that run directly on FPGAs. Complex compilers extract any parallellism that can be expressed in those languages, but to utilize the full capabilities of FPGAs many extensions has to be used, which the languages are not designed for. An analysis of a modern FPGA architecture is performed , and a model is created that reflects the internal wiring of the hardware of the FPGA. A language is designed based on a very simple traditional programming language. This new proposed language has a set of high-level syntax constructs that allow a programmer to describe more complex memory and computations in a simple manner where the architecture of the FPGA is abstracted away. The result is a model which is well suited for design space exploration, for which an area estimator is constructed which can estimate the required hardware resources of a given program on an FPGA with a precision in between 5% and 25%. A test indicates that a simple compilation of a FIR filter program compares well in both area and speed to a commercial implementation. Introduction First the problems of FPGA development is explained. Then an investigation is performed about how others have tried to solve the problems. Analysis The analysis concludes on the problems lied out in the introduction and outlines the problem investigated in the project. A deeper look is had on FPGA hardware, which ends up with a description about how computations can map to the hardware. Specification A specification for a language that is designed for the task of writing FPGA programs is laid out. Implementation This section will explain how an implementation of the specification of the former part is created. Test A test case is investigated, where a complex program is transformed into an FPGA description using the methods proposed in the project. Finally it is compared to a commercial implementation of the same algorithm. Conclusion The work done in the project is concluded, and reflected upon. Some suggestions are made about what could be done to further develop this method towards a …
Perceptions of drinking water cleanliness and health-seeking behaviours: A qualitative assessment of household water safety in Lesotho, Africa

ABSTRACT Despite the increased availability of improved water sources globally, enteric illnesses remain a source of significant morbidity and mortality. While the MDGs goal for safe water, i.e. improved sources, was met, substantial numbers of people still rely on unimproved sources for at least some of their water needs and contamination can occur between the source and consumption. Reviews and meta-analyses point to the need for better understanding of the cultural context for (HWT) technologies. Qualitative interviews (n = 56) conducted in the Maseru District of Lesotho (2011) addressed how people decided if their water was safe, their understanding of the linkage between water and enteric illness, and health-seeking behaviour. Respondents overwhelmingly relied on visual inspections to determine if their water was clean and not all participants linked consuming unsafe water with diarrheal disease. More than half of all respondents did not boil their water, despite believing that their primary source was not clean. People often have the knowledge necessary to ensure safe water but do not for myriad reasons, including financial constraints or habit. Data such as these are critical as the literature reveals often conflicting findings about the effectiveness of HWT and water safety takes on increasing importance in syndemic settings.
Quantitative Evaluations of the Effects of Noise on Mental Workloads Based on Pupil Dilation during Laparoscopic Surgery

Noise can exert undeniable pressure on human minds, especially during tasks that require high precision and attention, such as those performed during surgery. To investigate whether auditory stimuli increases mental loads during laparoscopic surgery, we examined the effects of operating room (OR) noises and music by measuring mean changes in pupil sizes and subjectively assessing performances during surgery. We recruited 24 subjects with varying laparoscopic surgery experience levels to perform complete appendectomy using a laparoscopic simulator. Wearable eye trackers were worn by all subjects to monitor pupil sizes during surgery, and surgical tasks were performed under conditions of silence, background OR noise, and music. National Aeronautics and Space Administration-Task Load Index scores and performance parameters were also recorded during surgical tasks. Noise distractions were associated with significant increases in pupil sizes compared with those observed in silence, and the related increases in mental loads may have affected surgical performance. However, more experienced operators had smaller changes in pupil sizes because of auditory disturbances than moderately experienced surgeons. Noise stimulation in the OR increases surgeon's mental workload and performance. Auditory regulation of the OR may be better standardized using data from studies of the effects of acoustic stimulation in the OR, and mental stresses during surgery could be considered in a more humane manner. Further investigations are necessary to determine the cognitive consequences of various auditory stimuli.
Outcomes of Sleeve Gastrectomy in Obese Liver Transplant Candidates

Morbid obesity (body mass index [BMI] ≥40 kg/m2) is a relative contraindication to liver transplantation (LT) at many transplant centers. The safety and efficacy of pre‐LT bariatric surgery in morbidly obese LT candidates is unknown. Herein, we describe a cohort study of morbidly obese LT candidates who failed to achieve adequate weight loss through a medically supervised weight loss program and subsequently underwent sleeve gastrectomy (SG) at our institution. In total, 32 LT candidates with a median Model for End‐Stage Liver Disease (MELD) score of 12 (interquartile range [IQR], 10‐13) underwent SG. All LT candidates had a history of hepatic decompensation, but complications of liver disease were required to be well controlled at the time of SG. Median pre‐SG BMI was 45.0 kg/m2 (IQR, 42.1‐49.0 kg/m2). There were no perioperative deaths or liver‐related morbidity. One patient experienced major perioperative morbidity secondary to a gastric leak, which was managed nonoperatively. Median weight loss at 6 and 12 months after SG was 22.0 kg (IQR, 18.9‐26.8 kg) and 31.0 kg (IQR, 23.6‐50.3 kg), respectively, corresponding to a percentage of excess body weight lost of 33.4% and 52.4%. Within 6 months after SG, 28 (88%) candidates were deemed eligible for LT. Our center’s experience highlights the potential option of SG in morbidly obese LT candidates with advanced liver disease who might otherwise be excluded from pursuing LT.
TNF May Negatively Regulate Phagocytosis of Devil Facial Tumour Disease Cells by Activated Macrophages

ABSTRACT Introduction: Macrophage phagocytosis of pathogens and tumour cells is an important early event in protection against infectious disease and cancer. As tumour necrosis factor α (TNF) is an important cytokine in macrophage activation, we investigated the involvement of TNF in macrophage phagocytosis of tumour cells. Methods: We used Devil Facial Tumour Disease (DFTD) cancer cells as the target tumour cells. The Tasmanian devil (Sarcophilus harrisii) population is threatened by the transmissible DFTD. Using DFTD cells provided the opportunity to determine if these cells can be phagocytosed and investigate requirement for TNF. As effector cells, bone marrow derived macrophages (BMDMs), generated from C57BL/6 wild type (B6.WT) and C57BL/6 TNF-/- (B6.TNF-/-) mice were used. Phagocytosis of DFTD cells was investigated by confocal microscopy and flow cytometry. Results: DFTD cells were consistently phagocytosed by B6.WT and B6.TNF-/- BMDMs with similar efficiency in vitro. Consequently the DFTD cells are not resistant to phagocytosis. Following activation by exposure to IFNγ and LPS or LPS alone, B6.TNF-/- BMDMs had higher phagocytic efficiency and lower nitric oxide (NO) production compared to wild-type controls. In addition, NO seems to be unlikely to be the involved in phagocytosis efficiency in IFNγ and LPS activated B6.TNF-/- macrophages and consequences thereof. Conclusion: Our results indicate that TNF is not required for IFNγ and LPS or LPS alone activation of macrophage phagocytosis. TNF may negatively regulate macrophage phagocytosis of tumour cells.
The contribution of health to educational inequalities in exit from paid employment in five European regions.

Objectives The primary aim of this study was to investigate educational inequalities in health-related exit from paid employment through different pathways in five European regions. A secondary objective was to estimate the proportion of different routes out of paid employment that can be attributed to poor health across educational groups in five European regions. Methods Longitudinal data from 2005 up to 2014 were obtained from the four-year rotating panel of the European Union Statistics on Income and Living Conditions (EU-SILC), including 337 444 persons with 1 056 779 observations from 25 countries. Cox proportional hazards models with censoring for competing events were used to examine associations between health problems and exit from paid employment. The population attributable fraction was calculated to quantify the impact of health problems on labor force exit. Results In all European regions, lower-educated workers had higher risks of leaving paid employment due to disability benefits [relative inequality (RI) 3.3-6.2] and unemployment (RI 1.9-4.5) than those with higher education. The fraction of exit from paid employment that could be attributed to poor health varied between the five European regions among lower-educated persons from 0.06-0.21 and among higher-educated workers from 0.03-0.09. The disadvantaged position of lower-educated persons on the labor market was primarily due to a higher prevalence of poor health. Conclusion In all European regions, educational inequalities exist in health-related exclusion from paid employment. Policy measures are needed to reduce educational inequalities in exit from paid employment due to poor health.
Rural stakeholder perceptions about cognitive screening

Abstract Objectives: The study aims were to explore stakeholder perceptions about cognitive screening in a rural, ethnically diverse, underserved setting, and to examine whether perceptions varied by years lived in a rural area, career, health literacy, willingness to be screened, ethnicity, education, or age. Methods: Twenty-one rural, ethnically diverse stakeholders completed an open-ended interview of five questions and a measure regarding perceptions about cognitive screening (PRISM-PC, Boustani, et al., 2008). Open coding using the in vivo process (Saldaña, 2015) to “derive codes from the actual participant language” (p. 77) was used to analyze the qualitative data. We used Pearson correlation to examine relationships between the PRISM-PC and sociodemographics including age, years of education, health literacy, years lived in rural areas, and willingness to participate in cognitive screening. Results: Eight codes and two themes were identified from the in vivo analysis. The eight codes were “a sentence being pronounced over the lives”, “keep everybody at home”, “Education is big”, the trust issues is everything here”, “identify support systems”, “access to care”, and “there is a cost to do that”. The two themes were “Trust is the essential component of connecting with Community”, and (2) “The Community recognizes the importance of knowledge in improving care. PRISM-PC results added new information in that persons were concerned about the emotional and financial burden on their families. Overall, regardless of age, careers, care involvement, health literacy, or education, 81% of stakeholders indicated they would seek annual cognitive screening. Discussion: It is important for rural health professionals to consider that contrary to previous stigma concerns, stakeholders may support earlier dementia detection.
Effects of Oral Health Education for Occupational Health Nurses

The purpose of this study was to evaluate effects of oral health education for occupational health nurses. The subjects were 300 occupational health nurses which participated in continuing education of Korean Association of Occupational Health Nurses. Oral health education contents consisted of basic knowledge about oral health, prevention of periodontal disease, oral health care for workers, and oral health program for workers. In order to evaluate the effects of oral health education, we performed questionnaire surveys before and after the education regarding their perceived oral health status and concern for oral health, knowledge about prevention of periodontal disease, attitude about oral health promotion, and needs for implementation of oral health promotion program. The data were analyzed by paired t-test to compare the change of knowledge and attitude according to the education. Linear regression analysis was carried out to assess the factors related to the improvement of their knowledge and attitude. The findings indicated that oral health knowledge and attitude of occupational health nurses were significantly improved by oral health education. A factor of the improvement of knowledge and attitude was concern for oral health. And they would like to be provided primarily oral health education for occupational health nurses. Finally, this study suggested that oral health education for occupational health nurses had significantly effects on improving oral health knowledge and attitude.
Dependence of the MR signal on the magnetic susceptibility of blood studied with models based on real microvascular networks

The primary goal of this study was to estimate the value of β , the exponent in the power law relating changes of the transverse relaxation rate and intra‐extravascular local magnetic susceptibility differences as ΔR2∗∝(Δχ)β . The secondary objective was to evaluate any differences that might exist in the value of β obtained using a deoxyhemoglobin‐weighted Δχ distribution versus a constant Δχ distribution assumed in earlier computations. The third objective was to estimate the value of β that is relevant for methods based on susceptibility contrast agents with a concentration of Δχ higher than that used for BOLD fMRI calculations.
Heavy metals content and distribution in basil (Ocimum basilicum L.) as influenced by cadmium and different potassium sources

Abstract Despite the fact that cadmium (Cd) is a non-essential element for plants, it can influence nutrients and affect human health. Potassium (K) can influence the transportation of heavy metals (HMs) in soil-plant systems. Here, a greenhouse experiment was conducted to evaluate the effect of Cd and K fertilizers on the different partitioning forms of HMs, their concentrations, uptake in the shoots and roots of Ocimum basilicum. Treatments comprised 2 levels of Cd (0 and 40 mg kg−1) and three levels of K (0, 100, and 200 mg kg−1) from three sources, i.e. KCl, K2SO4, and K-nano-chelate. 40 mg Cd kg−1 increased the shoot (above ground parts) Cd concentration. Addition of K as KCl, K2SO4, and K-nano-chelate increased the presence of Cd in shoots by 86, 82 and 76%, respectively, compared to the control. Using the nano-chelate of K can increase the accumulation of Cd in plants grown on contaminated soils to lesser content than that of the other forms of K. Application of 40 mg Cd kg−1 reduced the concentration of Zn, Cu, and Mn in the shoot, but increased shoot Fe concentration. Transfer factor (TF), which is the ratio of metal concentration in shoot to its concentration in root, of the studied HMs, was significantly affected by Cd and K treatments. Therefore, the proper form and dose of chemical fertilizers should be applied in Cd-contaminated soils.
An Improved Unauthorized Unmanned Aerial Vehicle Detection Algorithm Using Radiofrequency-Based Statistical Fingerprint Analysis

Unmanned aerial vehicles (UAVs) are now readily available worldwide and users can easily fly them remotely using smart controllers. This has created the problem of keeping unauthorized UAVs away from private or sensitive areas where they can be a personal or public threat. This paper proposes an improved radio frequency (RF)-based method to detect UAVs. The clutter (interference) is eliminated using a background filtering method. Then singular value decomposition (SVD) and average filtering are used to reduce the noise and improve the signal to noise ratio (SNR). Spectrum accumulation (SA) and statistical fingerprint analysis (SFA) are employed to provide two frequency estimates. These estimates are used to determine if a UAV is present in the detection environment. The data size is reduced using a region of interest (ROI), and this improves the system efficiency and improves azimuth estimation accuracy. Detection results are obtained using real UAV RF signals obtained experimentally which show that the proposed method is more effective than other well-known detection algorithms. The recognition rate with this method is close to 100% within a distance of 2.4 km and greater than 90% within a distance of 3 km. Further, multiple UAVs can be detected accurately using the proposed method.
Association of human papillomavirus and bacterial vaginosis with increased risk of high-grade squamous intraepithelial cervical lesions

Objective To assess the rates of co-infections between human papillomavirus (HPV) and 13 key markers of bacterial vaginosis in cervical samples by multiplex polymerase chain reaction in a population with a high rate of abnormal cytology and a positive HPV test. Methods The study included a total of 213 women aged 18–72 years screened using Papanicolaou smears for determining cervical abnormalities and for HPV and bacterial vaginosis by single-target and multiplex polymerase chain reaction. Results A total of 83 (39%) women were negative for intraepithelial lesion or malignancy cytology and 130 (61%) had abnormal cytology. HPV-DNA prevalence was 69.9% and bacterial vaginosis was 72.7 %. Co-infections between bacterial vaginosis with HPV-DNA and high-risk HPV were associated with an increased risk for squamous intraepithelial lesions of low-grade cytology and high-grade squamous intraepithelial lesions plus cervical cancer. The most frequent bacterial vaginosis agent was Gardnerella vaginalis (33.8%), and co-infection with HPV-DNA and high-risk HPV increased the risk for squamous intraepithelial lesions of low grade cytology and high-grade squamous intraepithelial lesions plus cervical cancer. Co-infection between Megasphaera type I and high-risk HPV increased the risk for high-grade squamous intraepithelial lesions plus cervical cancer. Conclusions Our results reinforce the hypothesis that some bacterial vaginosis agents may play a role as co-factors in HPV-mediated cervical carcinogenesis, at least in some populations.
Genetic predisposition to colorectal cancer: syndromes, genes, classification of genetic variants and implications for precision medicine

This article reviews genes and syndromes associated with predisposition to colorectal cancer (CRC), with an overview of gene variant classification. We include updates on the application of preventive and therapeutic measures, focusing on the use of non‐steroidal anti‐inflammatory drugs (NSAIDs) and immunotherapy. Germline pathogenic variants in genes conferring high or moderate risk to cancer are detected in 6–10% of all CRCs and 20% of those diagnosed before age 50. CRC syndromes can be subdivided into nonpolyposis and polyposis entities, the most common of which are Lynch syndrome and familial adenomatous polyposis, respectively. In addition to known and novel genes associated with highly penetrant CRC risk, identification of pathogenic germline variants in genes associated with moderate‐penetrance cancer risk and/or hereditary cancer syndromes not traditionally linked to CRC may have an impact on genetic testing, counseling, and surveillance. The use of multigene panels in genetic testing has exposed challenges in the classification of variants of uncertain significance. We provide an overview of the main classification systems and strategies for improving these. Finally, we highlight approaches for integrating chemoprevention in the care of individuals with genetic predisposition to CRC and use of targeted agents and immunotherapy for treatment of mismatch repair‐deficient and hypermutant tumors. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Off-Pump Coronary Bypass Grafting in a Post-pneumonectomy Patient: Challenges and Management

Pulmonary complications are common in cardiac surgical patients. Limited respiratory reserves along with the pain associated with sternotomy add to the morbidity. Patients undergoing cardiac surgery who have had a pneumonectomy done before can be even more challenging to manage perioperatively due to a single-functioning lung. We present a case of a postpneumonectomy patient who underwent off-pump coronary artery bypass grafting. Perioperative optimization of lung function tests was stressed upon including the chest physiotherapy and early mobilization. Preoperative thoracic epidural catheter was inserted for postoperative pain and other proven benefits of thoracic epidural in coronary artery disease patients. We could conclude from our experience that proper optimization of lung function tests and meticulous pain management along with fast-tracking are keys to the management of such patients.
Efficacy of antiseizure prophylaxis in chronic subdural hematoma: a cohort study on routinely collected health data.

OBJECTIVE: Chronic subdural hematoma (CSDH) is a common neurosurgical condition that can result in significant morbidity. The incidence of epileptic events associated with CSDH reported in the literature varies considerably and could potentially increase morbidity and mortality rates. The effectiveness of antiepileptic prophylaxis for this indication remains unclear. The primary objective of this study was to assess the relevance of anticonvulsant prophylaxis in reducing seizure events in patients with CSDH. METHODS: All consecutive cases of CSDH from January 1, 2005, to May 30, 2014, at the Hôpital de l'Enfant-Jésus in Quebec City were retrospectively reviewed. Sociodemographic data, antiepileptic prophylaxis use, incidence of ictal events, and clinical and radiological outcome data were collected. Univariate analyses were done to measure the effect of antiepileptic prophylaxis on ictal events and to identify potential confounding factors. Multivariate logistic regression was performed to evaluate factors associated with epileptic events. RESULTS: Antiepileptic prophylaxis was administered in 28% of the patients, and seizures occurred in 11%. Univariate analyses showed an increase in the incidence of ictal events in patients receiving prophylaxis (OR 5.92). Four factors were identified as being associated with seizures: septations inside the hematoma, membranectomy, antiepileptic prophylaxis, and a new deficit postoperatively. Antiepileptic prophylaxis was not associated with seizures in multivariate analyses. CONCLUSIONS: Antiepileptic prophylaxis does not seem to be effective in preventing seizures in patients with CSDH. However, due to the design of this study, it is difficult to conclude definitively about the usefulness of this prophylactic therapy that is widely prescribed for this condition.