Miracle-dz/UniFAR-FTUs huggingface dataset:
Co-occurring problems of early onset persistent, childhood limited, and adolescent onset conduct problem youth.

BACKGROUND It is increasingly recognized that youth who follow early onset persistent (EOP), childhood limited (CL) and adolescent onset (AO) trajectories of conduct problems show somewhat varying patterns of risk (in childhood) and adjustment problems (in adolescence and adulthood). Little, however, is known about how other adjustment problems differentially co-develop with the EOP, CL and AO trajectories across the childhood and adolescent years. METHOD Using data from the Avon Longitudinal Study of Parents and Children, an epidemiological, longitudinal cohort of boys and girls, we estimated growth curves for parent-reported hyperactivity, emotional difficulties, peer relational problems, and prosocial behaviors conditional on trajectories of conduct problems (i.e., EOP, CL and AO) from ages 4 to 13 years. At ages 7-8 years, DSM-IV-based diagnoses of conduct disorder, oppositional-defiant disorder, attention deficit/hyperactivity disorder (ADHD), anxiety, depression were examined by conduct problems trajectory. RESULTS Overall, the development of hyperactivity, emotional difficulties, peer relational problems, and prosocial behaviors mirrored the development of conduct problems, showing similar trajectories. CONCLUSIONS Results indicated that the problems of EOP youth were persistent across domains, CL youth showed decreased behavior problems while increasing in prosocial behaviors, and AO youth increased in adjustment problems after 10 years of age.
Connectivity Analysis as a Novel Approach to Motor Decoding for Prosthesis Control

The use of neural signals for prosthesis control is an emerging frontier of research to restore lost function to amputees and the paralyzed. Electrocorticography (ECoG) brain-machine interfaces (BMI) are an alternative to EEG and neural spiking and local field potential BMI approaches. Conventional ECoG BMIs rely on spectral analysis at specific electrode sites to extract signals for controlling prostheses. We compare traditional features with information about the connectivity of an ECoG electrode network. We use time-varying dynamic Bayesian networks (TV-DBN) to determine connectivity between ECoG channels in humans during a motor task. We show that, on average, TV-DBN connectivity decreases from baseline preceding movement and then becomes negative, indicating an alteration in the phase relationship between electrode pairs. In some subjects, this change occurs preceding and during movement, before changes in low or high frequency power. We tested TV-DBN output in a hand kinematic decoder and obtained an average correlation coefficient (r2) between actual and predicted joint angle of 0.40, and as high as 0.66 in one subject. This result compares favorably with spectral feature decoders, for which the average correlation coefficient was 0.13. This work introduces a new feature set based on connectivity and demonstrates its potential to improve ECoG BMI accuracy.
Molecular advances in genetic skin diseases

The genes for several genetic skin diseases have been identified in recent years. This development improves diagnostic capabilities and genetic counseling, and investigators can now turn to the molecular mechanisms involved in the pathogenesis of these diseases. The identification of the causative genes has led to the generation of mouse models for some genetic skin diseases. A study of the keratin 10 deficient mouse, a model for epidermolytic hyperkeratosis, and a mouse model for Bloom syndrome are reviewed in this article. Several studies also evaluate the relation between genotype and phenotype. In this article, the clinical findings and molecular advances in tuberous sclerosis complex, neurofibromatosis type 1, Bloom syndrome, epidermolytic hyperkeratosis, X-linked ichthyosis, Netherton syndrome, and Hermansky-Pudlak syndrome are reviewed.
Manipulation of Muscle Creatine and Glycogen Changes DXA Estimates of Body Composition.

Standardising a dual x-ray absorptiometry (DXA) protocol is thought to provide a reliable measurement of body composition. PURPOSE We investigated the effects of manipulating muscle glycogen and creatine content independently and additively on DXA estimates of lean mass. METHOD Eighteen well-trained male cyclists undertook a parallel group application of creatine loading (n=9) (20 g/d for 5 d loading; 3 g/d maintenance) or placebo (n=9) with crossover application of glycogen loading (12 v 6 g/kg BM/d for 48 h) as part of a larger study involving a glycogen-depleting exercise protocol. Body composition, total body water, muscle glycogen and creatine content were assessed via DXA, bioelectrical impedance spectroscopy and standard biopsy techniques. Changes in the mean were assessed using the following effect-size scale: >0.2 small, >0.6, moderate, >1.2 large and compared with the threshold for the smallest worthwhile effect of the treatment. RESULTS Glycogen loading, both with and without creatine loading, resulted in substantial increases in estimates of lean body mass (mean ± SD; 3.0 ± 0.7 % and 2.0 ± 0.9 %) and leg lean mass (3.1 ± 1.8 %and 2.6 ± 1.0 %) respectively. A substantial decrease in leg lean mass was observed following the glycogen depleting condition (-1.4 ± 1.6 %). Total body water showed substantial increases following glycogen loading (2.3 ± 2.3 %), creatine loading (1.4 ± 1.9 %) and the combined treatment (2.3 ± 1.1 %). CONCLUSIONS Changes in muscle metabolites and water content alter DXA estimates of lean mass during periods in which minimal change in muscle protein mass is likely. This information needs to be considered in interpreting the results of DXA-derived estimates of body composition in athletes.
Detection and classification of power quality disturbances based on Hilbert-Huang transform and feed forward neural networks

This paper presents a hybrid detection method and classification Technique based on Hilbert-Huang Transform (HHT) and Feed Forward Neural Networks (FFNNs) to improve the efficient delivery and ensure accurate detection of quality disturbances in the electrical power grids. First, quantities characteristics of power quality disturbances (PQDs) are introduced according its parametrical conditions. Thereafter, a detection and recognition algorithm is used for single and multiple disturbances. Then, a decomposition process and features extraction using Empirical Mode Decomposition (EMD) is conducted for each of these distorted waveforms into Intrinsic Mode Functions (IMFs). Finally, these features are constructed using signal amplitude and frequency and then after fed to one of the powerful Artificial Intelligence Techniques in this field for training, evaluating and testing using (FFNNs) classifier to verify and confirm the effectiveness of the detection methodology.
Disinhibition and borderline personality disorder

We review different conceptions of inhibitory control that may be relevant to the regulatory problems featured in borderline personality disorder (BPD). These conceptions have often been framed with regard to personality traits of inhibitory control, but can also be related to cognitive measures of response suppression as well as affect regulation. Reactive behavioral inhibition is relatively unstudied in relation to BPD. A substantial amount of literature links executive function problems with BPD, but that literature has not isolated executive response inhibition nor been controlled for other personality disorder symptoms of antisociality, attention-deficit/hyperactivity disorder (ADHD), or depression, anxiety, or posttraumatic symptoms. We therefore conducted a study of this question looking at BPD symptoms in an adult sample with a small number of BPD subjects and other disorders. Results indicated that symptoms of BPD were correlated with response inhibition (measured by stop signal reaction time) even after controlling for the overlap of stop inhibition with ADHD, antisociality, and other Axis II disorder symptoms. We conclude by hypothesizing discrete developmental routes to BPD, based on different mechanism breakdowns, which would be amenable to empirical investigation at the cognitive or trait level of analysis.Portions of this work were supported by National Institute of Mental Health Grant R01-MH63146 (J.N., PI).
Effects of the Ca2+ Channel Antagonist Flunarizine on Visual Discrimination Learning

Recent studies report that the peripheral administration of Ca2+ channel antagonists improves memory while central administration impairs memory in neurologically intact subjects. This study compares the effects of systemic versus central administration of the Ca2+ channel antagonist flunarizine on visual discrimination learning. In Experiment 1, 60 five-day-old male chicks received an intraperitoneal injection of 0, 1, 10, or 25 mg/kg flunarizine. Each chick then received three post-treatment test sessions (+5 min, +30 min, and +24 h) consisting of 60 visual discrimination trials followed by 5 min of observation in an open field. Flunarizine produced a dose- and time-dependent facilitation of learning. Evaluation of open-field behaviors indicated that the dose of flunarizine required to increase spontaneous activity was 10 times higher than the dose required to facilitate visual discrimination learning. No other open-field behaviors were effected. In Experiment 2, 44 chicks received intracerbroventricular injections of 0, 100 nM, 100 micro M, or 1 mM flunarizine followed by visual discrimination training as described in Experiment 1. Ventricular injection of flunarizine significantly increased the number of errors made during acquisition and retention trials. These data are consistent with earlier studies showing that systemic, but not central, administration of Ca2+ channel antagonists facilitates learning.
Long-term risk of colorectal cancer after excision of rectosigmoid adenomas.

BACKGROUND AND METHODS Surveillance by repeated colonoscopy is currently recommended for patients with colorectal adenomas. We assessed the long-term risk of colorectal cancer after rigid-instrument sigmoidoscopy and polypectomy in 1618 patients with rectosigmoid adenomas (tumor of the rectum or distal sigmoid colon) who did not undergo surveillance. A total of 22,462 person-years of observation were accrued (mean, 14 years per patient). RESULTS The incidence of subsequent rectal cancer in these patients was similar to that in the general population (standardized incidence ratio, 1.2; 95 percent confidence interval, 0.7 to 2.1). Most rectal cancers developed in patients whose adenomas had been inadequately removed; the risk was very low after complete removal. The risk of subsequent colon cancer depended on the histologic type, size, and number of adenomas in the rectosigmoid. Among 842 patients with a rectosigmoid adenoma that was tubulovillous, villous, or large (greater than or equal to 1 cm), colon cancer developed in 31 patients. The standardized incidence ratio was 3.6 (95 percent confidence interval, 2.4 to 5.0) overall and 6.6 (95 percent confidence interval, 3.3 to 11.8) if there were multiple rectosigmoid adenomas. Among the remaining 776 patients with only small, tubular adenomas (whether single or multiple), colon cancer developed in only 4 patients. The standardized incidence ratio in this group was 0.5 (95 percent confidence interval, 0.1 to 1.3). CONCLUSIONS Follow-up colonoscopic examinations may be warranted in patients with tubulovillous, villous, or large adenomas in the rectosigmoid, particularly if the adenomas are also multiple. In patients with only a single, small tubular adenoma that is only mildly or moderately dysplastic (43 percent of our series), however, surveillance may not be of value because the risk of cancer is so low.
Combination of PolInSAR and LiDAR Techniques for Forest Height Estimation

Forests are simplified as homogeneous volumes constituted of randomly uniform particles, characterized by a constant extinction coefficient in the random volume over ground (RVoG) model, which has been extensively applied to polarimetric synthetic aperture radar (SAR) interferometry for forest height estimation. This letter takes into account the heterogeneous vertical structure reflected by the vertically varying extinction coefficient curve in the forest volume layer, and modifies the RVoG model to make it be more suitable for height inversion of forests with complex structures. For this purpose, the normalized extinction coefficient curve is fit by large-footprint light detection and ranging full waveform data using the Gaussian function. Finally, the varying extinction RVoG model is applied to forest height estimation using airborne L-band SAR data acquired by the E-SAR system. The results are compared with in situ measurements, which indicate that the varying extinction RVoG model can obtain more accurate results for forest height inversion.
A low-jitter mixed-mode DLL for high-speed DRAM applications

This paper presents a salient clock deskewing method with a mixed-mode delay-locked loop (MDLL) for high-speed synchronous DRAM applications. The presented method not only solves the resolution problem of conventional digital deskewing circuits, but also improves the jitter performance to the level of well-designed analog deskewing circuits, while keeping the power consumption and locking speed of digital deskewing circuits. The whole deskewing circuit is fabricated in a 3.3-V 0.6-/spl mu/m triple-metal CMOS process and occupies a die area of 0.45 mm/sup 2/. Measured rms jitter is 6.38 ps. The power consumption of the entire chip, including I/O peripherals, is 33 mW at 200 MHz with a 3.3-V supply.
Topography of cones and rods in the tree shrew retina

The topographical distribution of cones and rods in the tree shrew retina was analysed quantitatively in whole‐mounted retinae and horizontal semithin sections stained with cresyl violet or toluidine blue. The outer nuclear layer consists of a single layer of photoreceptor nuclei with the rod nuclei slightly displaced towards the outer plexiform layer. This facilitated quantification of the photoreceptor populations. The density of cones ranges from 12,000/mm2 in the peripheral retina to a maximum of 36,000/mm2 in the inferior retina. Unlike ganglion cell density, the density of cones does not peak in the temporal retina. Rod density, between 500/mm2 and 3,500/mm2, also peaks in the inferior retina, but not in the same region as cone density. Rods constitute from 1 to 14% of the photoreceptor population, depending on retinal location, and have a local minimum at the central area. Amongst the cones a regularly arrayed subpopulation of presumed blue‐sensitive cones is distinguished by its special staining properties. These cones constitute between 4 and 10% of the cone population depending on retinal location. A second, irregularly spaced, subpopulation of possibly pathological cones is also described.
Psychology of Computers: XIV. Cognitive Rehabilitation through Computer Games 1

The purpose of this study was to test the hypothesis that computer games may be an efficient therapeutic tool in a cognitive rehabilitation program. 60 subjects who showed attention difficulties with or without cerebral dysfunctions participated in a 12-hr. training program based on intensive use of a computer game. Analyses show improvement for the experimental group on scanning and tracking variables, notwithstanding the nature of their particular dysfunctions. Recommendations are presented regarding the nature and content of the cognitive tasks in a rehabilitation program.
Implementation of a quality improvement programme to support advance care planning in five hospitals across a health region

Objectives Advance care planning (ACP) can help patients with a terminal illness to prepare for the end of their lives. This report describes a regional service improvement initiative to increase the identification of hospital inpatients at this stage in their illnesses and to increase the number of such patients who are offered the opportunity to start the process of ACP. Methods Data were collected prospectively over a 7 month period from four acute hospital trusts and a specialist cancer centre in the South-West London region. Each unit identified a specific patient population who were screened for eligibility to engage in the process of ACP. Data concerning the reasons for eligibility, the suitability for discussion and the various reasons why patients did not complete the process, were recorded. Results Over a 7 month period 1980 patients were screened and 559 (28.2%) were found to be potentially eligible for an ACP discussion. Of these 227/559 (40.6%) were deemed suitable for a discussion by medical staff. The majority of these patients (195/227; 86%) were offered the opportunity to undergo ACP discussions and 144/195 (73.8%) agreed to begin the process of ACP. Conclusions This report shows that a targeted approach can result in increased uptake in the number of patients who engage in ACP. However, systematic identification of potentially eligible patients requires a significant investment of clinical time and resources.
Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell Proliferation

ABSTRACT Eight human and six chicken novel alternatively spliced (AS) variants of telomerase reverse transcriptase (TERT) were identified, including a human variant (Δ4-13) containing an in-frame deletion which removed exons 4 through 13, encoding the catalytic domain of telomerase. This variant was expressed in telomerase-negative normal cells and tissues as well as in transformed telomerase-positive cell lines and cells which employ an alternative method to maintain telomere length. The overexpression of the Δ4-13 variant significantly elevated the proliferation rates of several cell types without enhancing telomerase activity, while decreasing the endogenous expression of this variant by use of small interfering RNA (siRNA) technology reduced cell proliferation. The expression of the Δ4-13 variant stimulated Wnt signaling. In chicken cells, AS TERT variants containing internal deletions or insertions that eliminated or reduced telomerase activity also enhanced cell proliferation. This is the first report that naturally occurring AS TERT variants which lack telomerase activity stimulate cell proliferation.
Improving the performance profile of energy conservation measures at the Penn State University Park Campus

Purpose The purpose of this paper is to examine significant steps taken by the Pennsylvania State University (Penn State) to account for both energy cost savings and greenhouse gas (GHG) emissions reduction goals through strategic investments in energy conservation measures (ECMs) in campus buildings. Through an analysis of multiple years of investment in facility upgrades across the university, the impacts of ECMs of various types are characterized by building type. The standards and criteria for ECMs investments are also evaluated with the goal to develop a predictive tool to support decision making pertaining to an annual investment in a portfolio of ECMs that will maintain a trajectory to achieve both financial return on investment as well as GHG reduction goals. Design/methodology/approach This study is comprised of three main parts: analyzing the energy costs saving and GHG emissions reduction contribution of various building types in which ECMs were conducted, analyzing costs saving and GHG emissions reduction contribution of each ECM while considering the average annual investments made in them and estimating the impact of upgrading Penn State’s steam plants from firing a mixture of coal and natural gas to natural gas only on the GHG emissions. Findings These analyses help identify which types of buildings and ECMs would have larger savings and emissions reduction contributions. A calculator is also created to enable forecasting of costs saving and GHG emissions reduction of investment distribution strategy among ECMs. This study demonstrates that the calculator based on data from previous years will benefit decision makers in more wisely configuring the investment portfolio. Originality/value This paper fulfills an identical need to couple energy efficiency strategies coupled with the environmental impacts associated with different fossil fuel energy sources.
Evaluation of IgG4 response in ascariasis by ELISA for serodiagnosis

The excretory/secretory (ES) antigen(s) of Ascaris lumbricoides was fractionated into 10 fractions by gel chromatography on a Suparose 12 column in FPLC. Of these, the third fraction (Al III), showing binding activity with both IgE and IgG antibodies of A. lumbricoides infected patients' sera, was further resolved into 2 fractions (Al IIIa and Al IIIb) on passage through a Mono Q column. Al IIIb was found to be the most potent antigen due to its high binding affinity with IgE and IgG antibodies of Ascaris infected patients as evidenced by ELISA inhibition. Although a two to five‐fold increase of serum IgE level was observed in all helminthic parasite infected patients studied compared to control subjects, Al IIIb specific IgE was detected in sera of all Ascaris infected and only 40% of hookworm infected patients. When Al IIIb was tested by ELISA with sera of control subjects, Ascaris, hookworm, Strongyloides and Trichuris infected patients, strong binding was observed with the IgE and also IgG of all the Ascaris infected patients; however, it cross‐reacted with IgG in 50% of hookworm, 28.6% of Trichuris trichura and 22.2% of Strongyloides infected patients' sera; but with IgE only in 40% of hookworm infected patients' sera. Further study showed specific detection of IgG4 in all the serum samples of 65 Ascaris infected patients when Al IIIb antigen was allowed to react with different subclasses of IgG by ELISA, giving a sensitivity of 100%. Reactivities of Al IIIb with IgG1, and IgG3, were only 47.6 and 11.8% respectively and there was no reactivity with IgG2, subclass. No IgG4 reactivity against Al IIIb was observed in the sera of hookworm, Trichuris or Strongyloides infected patients and was similar to that observed with control subjects showing the 100% specificity of the test system. This study may therefore be regarded as a novel technique for serodiagnosis of ascariasis by measuring Ascaris specific IgG4.
Relationship of testosterone and osteocalcin levels during growth

Recent studies in mice have demonstrated that osteocalcin (OCN) regulates testosterone (T) production in males but not in females. We hypothesized that this novel bone‐testis axis may be most relevant during rapid skeletal growth to help maximize bone size. Thus we measured serum T, total and undercarboxylated (UC) OCN, and periosteal circumference at the radius in 56 boys (bone age 4 to 20 years). T was correlated with OCN (bone‐age‐adjusted r = 0.30, p = .024), with a similar trend for UC OCN. T began to increase in the boys at bone age 11 years, and OCN peaked at bone age 14 years. Thus we divided the boys into three groups: 4 to 10 years (n = 16), 11 to 14 years (n = 18), and 15 to 20 years (n = 22). In boys of bone age 11 to 14 years (but not the other two groups), OCN was correlated with T (r = 0.57, p = .013), with a similar trend for UC OCN; T, in turn, was correlated with periosteal circumference (r = 0.75, p < .001). Collectively, these findings support the recent observations in mice of a novel bone‐testis axis. Moreover, our data suggest that in human males, this axis may be most relevant during rapid skeletal growth, when T levels are rising under the influence of the hypothalamic‐pituitary axis and OCN is increasing due to skeletal growth. During this phase, OCN may further stimulate testicular T production, which, in turn, contributes to an increase in bone size. © 2011 American Society for Bone and Mineral Research