Miracle-dz/UniFAR-FTUs huggingface dataset:
Topological defects of tetratic liquid-crystal order on a soft spherical surface

We model the orientational and positional order of tetratically shaped molecules, each having four-fold structural symmetry, confined on a spherical surface. Our Monte Carlo simulation shows that at a high molecular density, a tetratic orientational order develops in the system, accompanied by eight disclinations arranged in an anticube configuration form on the hard spherical surface. We also consider an elastic-energy model, which consists of both Helfrich and Frank energies for a soft surface; the solution confirms the Monte Carlo study and further predicts the tetratic morphology that can be realized on the surface of a soft vesicle. Assuming that the induced interaction between these disclinations is repulsive, we demonstrate that the anticube structure has a lower free energy than, for example, the cubic structure.
Tailoring nanohybrids and nanocomposites for catalytic applications

Research on and development of inorganic–organic nanohybrids and nanocomposite materials has attracted increasing attention in recent years. Synthetic strategies for such materials vary from grafting or co-condensation of Si and C sources to the impregnation of silica with polymers. Nanohybrids, prepared using organosilanes, and nanocomposites, obtained by hard or soft templated synthesis, are discussed. Various strategies will be presented that demonstrate how additional carbon properties can be exploited maximising the activity, selectivity and stability of composite materials as solid catalysts. Composite materials allow for the extensive engineering of a catalyst enabling careful tuning of the type, amount and position of active sites, as well as the porosity and hydrophilic nature of the final catalyst. These materials not only combine the advantages of silica (e.g. thermal stability, rigidity, ordering) and carbon (e.g. flexibility, ductility) but also allow their synergetic action in various catalytic applications.
Yield and grain quality of spring barley as affected by biomass formation at early growth stages

Timely and reliable prediction of grain yield and quality of spring barley represents a key prerequisite for effective crop management. Within this study we evaluated the relationships between yield components, grain quality, biomass production and the number of tillers in different growth stages. For this purpose, in three years (2011-2013) multifactorial field trials focused on the combined effects of cultivar, sowing density and nitrogen nutrition were conducted. Based on ANOVA it was found that the formation of grain yield was affected by individual factors in the following order of importance: year, nitrogen, cultivar and sowing rate. The final grain yield significantly correlated both with the number of tillers and dry weight of above-ground biomass per unit area. The best estimation of yield provided both parameters at early growth stage (R = 0.83** and 0.81** for number of tillers and the above-ground biomass at BBCH 25). The grain protein content was inversely related to early growth parameters (R = -0.64** and -0.41** for number of tillers and above-ground biomass at BBCH 25). Based on the comparison of relationships between the years, it can be concluded that the early growth of barley and tiller differentiation is a key parameter for the formation of yield and grain quality.
LINC00649 Facilitates the Cellular Process of Bladder Cancer Cells via Signaling Axis miR-16-5p/JARID2

Bladder cancer (BC), as one of the most common cancers around the world, begins in the inner side of the bladder and is inclined to spread to the remaining parts of the body. Extensive documents have shown that long noncoding RNAs function as stimuli in various cancer types. With regard to LINC00649, there is limited investigation on its role previously. In our research, we discovered that LINC00649 was considerably highly expressed in BC cells and the lack of LINC00649 would cause inactivity in cellular proliferation, migration, and invasion. miR-16-5p turned out to be competitively incorporated by LINC00649 in the upstream or JARID2 downstream. In BC cells, LINC00649 was found to bind with miR-16-5p to increase the expression of JARID2. Overly expressed JARID2 was found to reverse the LINC00649 shortage-mediated suppressive impacts on the cellular process of BC cells. Concisely, it was the first study on the molecular mechanism of LINC00649 in BC. This work detected that LINC00649 enhanced cell proliferation, migration, and invasion of BC cells by acting as a sponge of miR-16-5p and upregulating JARID2, providing novel insight into understating BC.
Synthesis and effect of surface modified nano ZnO in natural rubber vulcanization

It is well known that surface of ZnO acts both as a reactant and a catalytic reaction template in rubber vulcanization by activating and bringing together reactants. The particles of accelerators, fatty acid, and sulfur diffuse through the polymer matrix and get adsorbed on the surface of ZnO, forming intermediate complexes. Hence dispersion of ZnO in the elastomer matrix is a determining parameter. Capping is one of the novel techniques for increasing ZnO-stearic acid/accelerator interaction, thereby enhancing their activities. During the sol–gel precipitation of nano ZnO, if a suitable capping agent is added, agglomeration of ZnO particles gets reduced, leading to the formation of nano particles. Since only very few studies are found reported on synthesis of accelerator-capped ZnO and its application in rubber vulcanization, attempts have been made in this study to synthesize our novel accelerator N-benzylimine aminothioformamide (BIAT)-capped-stearic acid-coated nano ZnO (ZOBS), and BIAT-capped ZnO (ZOB) to investigate their effects in natural rubber (NR) vulcanization. Efforts have also been made to synthesize stearic acid-coated nano zinc phosphate (ZPS) with an aim to find an alternative to conventional ZnO in vulcanization. Mechanical properties like tensile strength, tear resistance, abrasion resistance, and compression set were found out. Swelling values of the vulcanizates as a measure of crosslink densities were also determined. Optimum dosage of ZOBS and a combination of ZOB and ZPS were also derived and found that capped ZnO is superior in NR vulcanization to conventional ZnO in improving cure properties including scorch safety and mechanical properties. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Clinical outcomes among hemodialysis patients with atrial fibrillation: a Korean nationwide population-based study

Background The number of patients requiring dialysis is increasing worldwide, and the atrial fibrillation and atrial flutter (AF) prevalence among hemodialysis (HD) patients is higher than in the general population. There have been no studies of Korean AF patients undergoing HD that investigated how AF affects outcomes, such as all-cause mortality, hospitalization, and stroke events. We conducted a large-scale retrospective cohort study with data from the National Health Insurance System to determine how AF affects these outcomes. Methods In 2013, the Health Insurance Review and Assessment service, a Korean national health insurance scheme, collected data from 21,839 HD patients to evaluate the adequacy of dialysis centers. All-cause mortality, hospitalization, and stroke events were compared between patients with and without AF. Sub-analyses compared these outcomes between AF patients receiving warfarin and those not receiving warfarin. Results Cox regression analysis found that AF was a significant risk factor for death from any cause (hazard ratio [HR], 1.356; 95% confidence interval [CI], 1.222–1.506; p < 0.001), hospitalization (HR, 1.323; 95% CI, 1.225–1.430; p < 0.001), and hemorrhagic stroke (HR, 1.500; 95% CI, 1.050–2.141; p = 0.026). AF was not significantly associated with an increased risk of ischemic stroke. The use of warfarin was significantly associated with hemorrhagic stroke incidence (HR, 1.593; 95% CI, 1.075–2.360; p = 0.020), while there was no significant correlation between warfarin treatment and all-cause mortality, hospitalization, and ischemic stroke. Conclusion This cohort study of Korean dialysis patients showed that AF was a risk factor for multiple outcomes among HD patients.
Suicide Ideation and Its Correlates Among University Undergraduates in South Western Nigeria

Suicide is one of the leading causes of death among young people aged 15 to 29 years of age. Ideation or suicidal thoughts , which precedes suicide is sometimes normalized and excused thereby missing avertable deaths within a given context. Understanding suicide ideation and the associated social correlates within contexts can provide cues on how to mitigate suicide. This paper examines the potential social factors that are shaping suicidal ideation among young people in two universities in Nigeria. Based on a mixed-method design, a survey was conducted among a proportionate sample of 500 young people (18–25years that are undergraduates). Four Focus Group Discussion sessions were also held among the same group and six semi-structured interviews with social workers at both universities. Quantitative evidence associated irregular financial support (OR = 0.60; p < 0.05) and broken intimate relationship (OR = 1.57; P < 0.05) with suicide ideation. Findings from the qualitative component also considered undergraduates that have academic challenges, engage in substance abuse, and have parents with marital problems to be prone to suicidal ideation. Suicidal ideation among these young people is embedded in their network of relationships, which can be mitigated when the quality of support systems is responsive and adequately accessed.
Regeneration in anamniotes was replaced by regengrow and scarring in amniotes after land colonization and the evolution of terrestrial biological cycles

An evolutionary hypothesis explaining failure of regeneration among vertebrates is presented. Regeneration derives from postembryonic processes present during the life cycles of fish and amphibians that include larval and metamorphic phases with broad organ reorganizations. Developmental programs imprinted in their genomes are re‐utilized with variations also in adults for regeneration. When vertebrates colonized land adopting the amniotic egg, some genes driving larval changes, and metamorphosis were lost and new genes evolved, further limiting regeneration. These included neural inhibitors for maintaining complex nervous systems, behavior and various levels of intelligence, and adaptive immune cells. The latter, that in anamniotes are executioners of metamorphic reorganization, became intolerant to embryonic‐oncofetal‐antigens impeding organ regeneration, a process that requires de‐differentiation of adult cells and/or expansion of stem cells where these early antigens are formed. The evolution of terrestrial lifecycles produced vertebrates with complex bodies but no longer capable to regenerate their organs, mainly repaired by regengrow. Efforts of regenerative medicine to improve healing in humans should determine the diverse developmental pathways evolved between anamniotes and amniotes before attempting genetic manipulations such as the introduction of “anamniote regenerative genes” in amniotes. This operation may determine alteration in amniote developmental programs leading to teratomes, cancer, or death.
In vivo photoprotective effect of I-bis(carboxyethyl)germanium sesquioxide

In this paper in vivo radical scavenger activity of β-bis(carboxyethyl)germanium sesquioxide (CEG) was investigated. CEG aqueous solutions were topically applied to healthy human volunteers before and after skin exposure to UVB radiation. Skin erythema was monitored by calculating erythema index values from the skin spectral data obtained using a reflectance spectrophotometer. The results of these experiments indicated that CEG was not able to inhibit UVB-induced skin erythema both in the pretreatment and in the posttreatment protocol. In order to assess if the lack of CEG photoprotective activity was due to poor CEG in vivo skin permeation, we tested CEG aqueous formulations containing a skin penetration enhancer such as dimethylisosorbide (DMI). CEG aqueous solutions containing DMI were able to reduce UVB-induced skin erythema when applied before skin exposure to UV radiation, but they were ineffective when topically applied after UVB irradiation.
Conserved DNA sequence features underlie pervasive RNA polymerase pausing

Abstract Pausing of transcribing RNA polymerase is regulated and creates opportunities to control gene expression. Research in metazoans has so far mainly focused on RNA polymerase II (Pol II) promoter-proximal pausing leaving the pervasive nature of pausing and its regulatory potential in mammalian cells unclear. Here, we developed a pause detecting algorithm (PDA) for nucleotide-resolution occupancy data and a new native elongating transcript sequencing approach, termed nested NET-seq, that strongly reduces artifactual peaks commonly misinterpreted as pausing sites. Leveraging PDA and nested NET-seq reveal widespread genome-wide Pol II pausing at single-nucleotide resolution in human cells. Notably, the majority of Pol II pauses occur outside of promoter-proximal gene regions primarily along the gene-body of transcribed genes. Sequence analysis combined with machine learning modeling reveals DNA sequence properties underlying widespread transcriptional pausing including a new pause motif. Interestingly, key sequence determinants of RNA polymerase pausing are conserved between human cells and bacteria. These studies indicate pervasive sequence-induced transcriptional pausing in human cells and the knowledge of exact pause locations implies potential functional roles in gene expression.
An assessment of risk factors for contracting rabies among dog bite cases recorded in Ward 30, Murewa district, Zimbabwe

Background Zoonoses are a major threat to human health. Worldwide, rabies is responsible for approximately 59 000 deaths annually. In Zimbabwe, rabies is one of the top 5 priority diseases and it is notifiable. It is estimated that rabies causes 410 human deaths per year in the country. Murewa district recorded 938 dog bite cases and 4suspected rabies deaths between January 2017 and July 2018, overshooting the threshold of zero rabies cases. Of the 938dog bite cases reported in the district, 263 were reported in Ward 30 and these included all the 4suspected rabies deaths reported in the district. This necessitated a study to assess risk factors for contracting rabies in Ward 30, Murewa. Methodology/ Principal findings A descriptive cross sectional survey was used for a retrospective analysis of a group of dog bite cases reported at Murewa Hospital, in Ward 30. Purposive sampling was used to select dog bite cases and snowball sampling was used to locate unvaccinated dogs and areas with jackal presence. The dog bite cases and relatives of rabies cases were interviewed using a piloted interviewer-administered questionnaire. Geographical Positioning System (GPS) coordinates of dog bite cases, vaccinated and unvaccinated dogs and jackal presence were collected using handheld GPS device. QGIS software was used to spatially analyse and map them. Dog owners were 10 times more likely to contract rabies compared to non-dog owners (RR = 10, 95% CI 1.06–93.7). Owners of unvaccinated dogs were 5 times more likely to contract rabies compared to owners of vaccinated dogs (RR = 5.01, 95% CI 0.53–47.31). Residents of the high density cluster (area with low cost houses and stand size of 300 square meters and below) were 64 times more likely to contract rabies compared to non-high density cluster residents (RR = 64.87, 95% CI 3.6039–1167.82). Participants who were not knowledgeable were 0.07 times more likely to contract rabies, compared to those who had knowledge about rabies. (RR = 0.07, 95% CI 0.004–1.25). Our study shows that the risk factors for contacting rabies included; low knowledge levels regarding rabies, dog ownership residing in the high density cluster, owning unvaccinated dogs and spatial overlap of jackal presence with unvaccinated dogs.
Long Noncoding RNA EGOT Responds to Stress Signals to Regulate Cell Inflammation and Growth

Key Points Cell stress induces the expression of EGOT via the PI3K/AKT, MAPK, and NF-κB pathways. EGOT favors the expression of PI3K/AKT target genes required for cell proliferation. EGOT supports TBLR1 expression, contributing to transcription of NF-κB target genes. The cell has several mechanisms to sense and neutralize stress. Stress-related stimuli activate pathways that counteract danger, support cell survival, and activate the inflammatory response. We use human cells to show that these processes are modulated by EGOT, a long noncoding RNA highly induced by viral infection, whose inhibition results in increased levels of antiviral IFN-stimulated genes (ISGs) and decreased viral replication. We now show that EGOT is induced in response to cell stress, viral replication, or the presence of pathogen-associated molecular patterns via the PI3K/AKT, MAPKs, and NF-κB pathways, which lead to cell survival and inflammation. Transcriptome analysis and validation experiments show that EGOT modulates PI3K/AKT and NF-κB responses. On the one hand, EGOT inhibition decreases expression of PI3K/AKT–induced cellular receptors and cell proliferation. In fact, EGOT levels are increased in several tumors. On the other hand, EGOT inhibition results in decreased levels of key NF-κB target genes, including those required for inflammation and ISGs in those cells that build an antiviral response. Mechanistically, EGOT depletion decreases the levels of the key coactivator TBLR1, essential for transcription by NF-κB. In summary, EGOT is induced in response to stress and may function as a switch that represses ISG transcription until a proper antiviral or stress response is initiated. EGOT then helps PI3K/AKT, MAPKs, and NF-κB pathways to activate the antiviral response, cell inflammation, and growth. We believe that modulation of EGOT levels could be used as a therapy for the treatment of certain viral infections, immune diseases, and cancer.
The influence of the organic aerosol component on CCN supersaturation spectra for different aerosol types

Abstract This paper describes the effect of the presence of water-soluble organic compounds (WSOC) in aerosol particles on the aerosol critical supersaturation as defined by the Köhler theory and on cloud condensation nuclei (CCN) number concentration. Taking into account both the soluble mass increase and the surface tension depression due to WSOC, we calculated a substantial decrease of the aerosol critical supersaturation, which results in a large increase in CCN number concentration. CCN supersaturation spectra were computed for three different aerosol types: marine, rural and urban. The increase of CCN number concentration in the presence of WSOC (with respect to the case when only the inorganic aerosol compounds are considered) varies with aerosol type, with an increase up to 13% in the marine case, up to 97% in the rural case, and up to 110% in the urban case, for the supersaturation range typical of atmospheric conditions.
The Role of UBI in Mitigating the Effects of Psychosocial Stressors: A Review and Proposal

Psychosocial stressors and social disadvantages contribute to inequalities in opportunities and outcomes. In the current paper, we use an epidemiological perspective and highlight the role stress plays on individuals by reviewing the outcomes of major stressors such as poverty and unemployment. We further analyzed the psychological and physical cost of these stressors and their long-term impact. We examined the role of universal basic income and closely looked at income experiments that were implemented in the past, in terms of their effectiveness in enhancing the community as well as individual outcomes and propose the UBI as a tool for alleviating the impact of these stressors. At a time when a major pandemic (e.g., COVID-19) threatens economic stability and health globally, we believe the UBI is relevant now, more than ever.
Associating fluids with four bonding sites against a hard wall: density functional theory

We present two new perturbation density functional theories to investigate non-uniform fluids of associating molecules. Each fluid molecule is modelled as a spherical hard core with four highly anisotropic square well sites placed in tetrahedral symmetry on the hard core surface. In one theory we apply the weighting from Tarazona's hard sphere density functional theory to Wertheim's bulk first-order perturbation theory. The other theory uses the inhomogeneous form of Wertheim's theory as a perturbation to Tarazona's hard-sphere density functional theory. Each theory approaches Tarazona's theory in the limit of zero association. We compare results from theory and simulation for density profiles, fraction of monomers, and adsorption of an associating fluid against a hard, smooth wall over a range of temperatures and densities. The non-uniform fluid theory which uses Tarazona's weighting of Wertheim's theory in the bulk is in good agreement with computer simulation results.
Health Insurance Status as a Predictor of Mode of Colon Cancer Detection but Not Stage at Diagnosis: Implications for Early Detection

Objective For colon cancer patients, one goal of health insurance is to improve access to screening that leads to early detection, early-stage diagnosis, and polyp removal, all of which results in easier treatment and better outcomes. We examined associations among health insurance status, mode of detection (screen detection vs symptomatic presentation), and stage at diagnosis (early vs late) in a diverse sample of patients recently diagnosed with colon cancer from the Chicago metropolitan area. Methods Data came from the Colon Cancer Patterns of Care in Chicago study of racial and socioeconomic disparities in colon cancer screening, diagnosis, and care. We collected data from the medical records of non-Hispanic Black and non-Hispanic White patients aged ≥50 and diagnosed with colon cancer from October 2010 through January 2014 (N = 348). We used logistic regression with marginal standardization to model associations between health insurance status and study outcomes. Results After adjusting for age, race, sex, and socioeconomic status, being continuously insured 5 years before diagnosis and through diagnosis was associated with a 20 (95% CI, 8-33) percentage-point increase in prevalence of screen detection. Screen detection in turn was associated with a 15 (95% CI, 3-27) percentage-point increase in early-stage diagnosis; however, nearly half (47%; n = 54) of the 114 screen-detected patients were still diagnosed at late stage (stage 3 or 4). Health insurance status was not associated with earlier stage at diagnosis. Conclusions For health insurance to effectively shift stage at diagnosis, stronger associations are needed between health insurance and screening-related detection; between screening-related detection and early stage at diagnosis; or both. Findings also highlight the need to better understand factors contributing to late-stage colon cancer diagnosis despite screen detection.