Miracle-dz/UniFAR-FTUs huggingface dataset:
Postbiopsy splenic bleeding in a dog model: comparison of cauterization, embolization, and plugging of the needle tract.

OBJECTIVE The purpose of our study was to compare radiofrequency cauterization, embolization using an absorbable gelatin sponge, and a Histoacryl-Lipiodol mixture plugging as postbiopsy bleeding reduction methods after splenic core needle biopsy in a dog model. MATERIALS AND METHODS Eleven mongrel dogs were randomly separated into nonheparinized (n = 5) and heparinized (n = 6) groups. Eight splenic biopsies per animal were performed using an 18-gauge automated core biopsy needle: two as controls, two ablated by radiofrequency, two embolized using an absorbable gelatin sponge, and two plugged using a Histoacryl-Lipiodol mixture. Procedure times and postbiopsy bleeding amounts were assessed. Statistically significant differences were determined by repeated measures analysis of variance; the Tukey-Kramer test for multiple comparisons was used for post hoc comparisons. Three-day follow-up CT scans were obtained to check for procedure-related complications or delayed bleeding. RESULTS The postbiopsy bleeding reduction groups showed significantly less blood loss than the control group for both the nonheparinized (p < 0.0001) and heparinized groups (p < 0.0001). In the heparinized group, both radiofrequency cauterization (p < 0.01) and gelatin sponge embolization (p < 0.05) significantly reduced bleeding compared with Histoacryl-Lipiodol mixture plugging. Gelatin sponge embolization was the longest procedure (p < 0.001). On follow-up CT, no delayed bleeding was observed. However, multiple Histoacryl-Lipiodol emboli were observed in the splenic and portal veins in all the dogs we treated. CONCLUSION Radiofrequency cauterization was found to be the most useful postbiopsy bleeding reduction method in terms of the amount of bleeding and the procedure time.
Time-Resolved Contrast-Enhanced Magnetic Resonance Angiography of the Lower Extremity

The aim of this prospective study was to evaluate the feasibility and clinical use of time-resolved magnetic resonance angiography (MRA) of the lower extremity compared to intraarterial digital subtraction angiography (IA-DSA). Twenty-two patients suffering from peripheral arterial occlusive disease underwent MRA and IA-DSA. MRA examinations were performed on a 1.5 T system equipped with a 4-element-array coil. The area from the distal abdominal aorta to the distal lower limb was covered by 2-3 examination steps. A T1-weighted gradient echo sequence with a temporal resolution of 7-10 s was used. Single-dose contrast material (0.1 mm/kg) was injected with a flow rate of 2 mL/s, followed by a 40 mL saline flush. Pre and post contrast images were subtracted, and the subtracted data set was postprocessed with maximum intensity projection (MIP). In all patients diagnostic images could be obtained. Problems with venous overlay or incomplete arterial filling were not present. Sensitivity for the detection of relevant stenoses (>50%) was 96.7%, specificity was 97%. Concerning the detection of occlusions, sensitivity was 97.8%, specificity was 99.2%. Time-resolved contrast-enhanced MRA of the lower extremity is a robust procedure with high accuracy in the detection of relevant stenoses and occlusions.
The Emerging Role of the Cytoskeleton in Chromosome Dynamics

Chromosomes underlie a dynamic organization that fulfills functional roles in processes like transcription, DNA repair, nuclear envelope stability, and cell division. Chromosome dynamics depend on chromosome structure and cannot freely diffuse. Furthermore, chromosomes interact closely with their surrounding nuclear environment, which further constrains chromosome dynamics. Recently, several studies enlighten that cytoskeletal proteins regulate dynamic chromosome organization. Cytoskeletal polymers that include actin filaments, microtubules and intermediate filaments can connect to the nuclear envelope via Linker of the Nucleoskeleton and Cytoskeleton (LINC) complexes and transfer forces onto chromosomes inside the nucleus. Monomers of these cytoplasmic polymers and related proteins can also enter the nucleus and play different roles in the interior of the nucleus than they do in the cytoplasm. Nuclear cytoskeletal proteins can act as chromatin remodelers alone or in complexes with other nuclear proteins. They can also act as transcription factors. Many of these mechanisms have been conserved during evolution, indicating that the cytoskeletal regulation of chromosome dynamics is an essential process. In this review, we discuss the different influences of cytoskeletal proteins on chromosome dynamics by focusing on the well-studied model organism budding yeast.
Weak Lambertian assumption for determining cylindrical shape and pose from shading and contour

Weak Lambertian assumption is proposed and used to determine shape and pose of cylindrical objects from a monocular intensity image. The method does not require the knowledge of lighting conditions (light intensity and lighting direction), surface properties, or albedos. Experimental results for both synthesized and real images showing the validity of the method are presented. <<ETX>>
Hallmarks of progeroid syndromes : lessons from mice and reprogrammed cells

Ageing is a process that inevitably affects most living organisms and involves the accumulation of macromolecular damage, genomic instability and loss of heterochromatin. Together, these alterations lead to a decline in stem cell function and to a reduced capability to regenerate tissue. In recent years, several genetic pathways and biochemical mechanisms that contribute to physiological ageing have been described, but further research is needed to better characterize this complex biological process. Because premature ageing (progeroid) syndromes, including progeria, mimic many of the characteristics of human ageing, research into these conditions has proven to be very useful not only to identify the underlying causal mechanisms and identify treatments for these pathologies, but also for the study of physiological ageing. In this Review, we summarize the main cellular and animal models used in progeria research, with an emphasis on patient-derived induced pluripotent stem cell models, and define a series of molecular and cellular hallmarks that characterize progeroid syndromes and parallel physiological ageing. Finally, we describe the therapeutic strategies being investigated for the treatment of progeroid syndromes, and their
Porcine follicle-stimulating hormone treatment of gilts during an altrenogest-synchronized follicular phase: effects on follicle growth, hormone secretion, ovulation, and fertilization.

Porcine FSH (SUPER OV), containing . 03% LH activity, and equine chorionic gonadotropin (eCG) were administered during an altrenogest-synchronized follicular phase to determine their effects on follicle development, estrus, ovulation, and fertilization. Treatments were made by i.m. injection starting on d 1 (24 h after the last feeding of altrenogest): 1) saline, once, n = 14; 2) eCG (1,200 to 1,500 IU) once, n = 32; 3) FSH 14 (n = 2) or 21 (n = 6) NIH-FSH-S1 units/100 kg BW, divided among six injections at 12-h intervals (FSH14/21); 4) FSH, 28 NIH-FSH-S1 units/100 kg BW, divided among six injections at 12-h intervals, n = 12; and 5) FSH, 28 NIH-FSH-S1 units/100 kg BW and 100 IU hCG, two or six injections at 12-h intervals (FSH28+hCG), n = 13. Gilts were injected with 750 IU of hCG on d 5 to ensure ovulation. Twenty-eight eCG- and FSH-injected gilts (n = 6, 8, and 11 on treatments 3, 4, and 5, respectively) were bred and laparotomized on d 7 to recover ova and record ovulation rate. The mean number of ovulations and large (6- to 10-mm) follicles, respectively, on d 7 were as follows: saline (17, .7), eCG (43, .9), FSH14/21 (15, .6), FSH28 (12, 16), and FSH28+hCG (32, 21). Plasma FSH concentrations were at least threefold higher (P < .05) in gilts treated with FSH than in gilts not treated with FSH. The percentage in estrus was higher (P < .05) for saline- and eCG-treated gilts (100 and 87%, respectively) than for FSH-treated gilts (53%). Proportion of FSH28+hCG-treated gilts with fertilized ova (27%) was lower than for other groups (79 to 100%). In summary, the 3-d high dose FSH treatment (FSH28 and FSH28+hCG) during an altrenogest-synchronized follicular phase increased the number of potentially ovulatory follicles, but this potential benefit was not realized because many follicles failed to ovulate. The co-injection of low doses of hCG (FSH28+hCG) increased the ovulation rate and estradiol secretion but reduced ova recovery and fertilization rate compared with eCG and the other FSH treatments.
Improving MapReduce Performance By Using A New Partitioner In YARN

Data skew, cluster heterogeneity, and network traffic are three issues that significantly influence the performance of MapReduce applications. However, the Hash-Partitioner in native Hadoop does not consider them. This paper proposes a new partitioner in Yarn (Hadoop 2.6.0), namely, PIY, which adopts an innovative parallel sampling method to achieve the distribution of the intermediate data. Based on this, firstly, PIY mitigates data skew in MapReduce applications. Secondly, PIY considers the heterogeneity of the computing resource to balance the load among Reducers. Thirdly, PIY reduces the network traffic in shuffle phase by trying to retain intermediate data on those nodes who act as both mapper and reducer. Compared with the native Hadoop and some other popular strategies, PIY can reduce the execution time by 35.62% and 50.65% in homogeneous and heterogeneous cluster, respectively. We also implement PIY in parallel image processing. Compared with several existing strategies, PIY can reduce the execution time by
Exploring How Different Project Management Methodologies Impact Data Science Students

This paper reports on a controlled experiment comparing different approaches on how to guide students through a semester long data science project. Four different methodologies, ranging from a traditional “just assign some intermediate milestones” to other more agile methodologies, are compared. The results of the experiment shows that the project methodology used in the classroom made a significant difference in student outcomes. Surprisingly, an Agile Kanban approach was found to be much more effective than an Agile Scrum methodology, which was not one of the leading ap-proaches.
New Frequency Plan and Reconfigurable 6.6 / 7.128 GHz CMOS Quadrature VCO for MB-OFDM UWB Application

This work presents a new frequency plan and a reconfigurable 6.6 / 7.128 GHz CMOS quadrature voltage-controlled oscillator (QVCO) with integrating differential switchable inductors. Based on this frequency plan, a further simple synthesizer architecture is proposed with only two PLL's, two mixers, and one multiplexer. The QVCO is implemented with the mutual-coupling structure of two differential LC-tuned oscillator cores in a 0.18 mum RF CMOS technology. The core stages draw a total of 10 mA from the supply voltage of 2.0 V. The measured phase noise at 6.6 GHz is -116 dBc/Hz at 1 MHz offset. By utilizing a switched capacitance array, a tuning range of 860 MHz is achievable with four sub-bands. The figure of merits (FOM) is about -178 dB. According to the new frequency plan, this QVCO can be served as one of the original signal sources for the MB-OFDM UWB frequency synthesizer.
Mobile interactive hologram verification

Verification of paper documents is an important part of checking a person's identity, authorization for access or simply establishing a trusted currency. Many documents such as passports or paper bills include holograms or other view-dependent elements that are difficult to forge and therefore are used to verify the genuineness of that document. View-dependent elements change their appearance based both on viewing direction and dominant light sources, thus it requires special knowledge and training to accurately distinguish original elements from forgeries. We present an interactive application for mobile devices that integrates the recognition of the documents with the interactive verification of view-dependent elements. The system recognizes and tracks the paper document, provides user guidance for view alignment and presents a stored image of the element's appearance depending on the current view of the document also recording user decisions. We describe how to model and capture the underlying spatially varying BRDF representation of view-dependent elements. Furthermore, we evaluate this approach within a user study and demonstrate that such a setup captures images that are recognizable and that can be correctly verified.
Self-assessed limited prosocial emotions do not distinguish community youth with psychosocial problems from those without them

Abstract Background: In DSM 5, conduct disorder was expanded with the new specifier ‘with limited prosocial emotions (LPE)’. These callous-unemotional traits have been emphasized as the ‘core’ of psychopathy syndrome providing greater information about current and future impairment. Individuals with callous-unemotional traits have shown elevated levels of impairment, and these traits have been suggested to serve as a useful indicator for psychiatric vulnerability and psychosocial maladjustment also among community youth. Aim: The aim of this study was to investigate the prevalence of LPE in a sample of Finnish mid-adolescent community youth, and to determine whether adolescents with and without LPE differ from each other in general psychopathology. Methods: A classroom survey was conducted among 9th graders at secondary schools (n = 446). The Antisocial Process Screening Device–Self-Report (APSD-SR) was used to assess LPE. The adolescents’ general psychopathology was assessed using the Youth Self Report (YSR). Results: Almost 10% of the adolescents met the criteria for LPE. Youth with LPE did not differ significantly from those without LPE on the Total Problems Score or on externalizing psychopathology. Only one statistically significant difference emerged in group comparisons; adolescents with LPE scored significantly lower on somatic complaints than their counterparts without LPE. Conclusions: LPE are a common phenomenon among community youth, and the specifier—as measured with a self-assessment—does not distinguish adolescents with psychosocial problems from those without them. More research is obviously needed to elucidate the role of LPE in juveniles.
Escala de atitudes frente ao heavy metal: exemplo de construção de uma medida tipo likert

O presente estudo tem por objetivo desenvolver a Escala de Atitudes frente ao Heavy Metal (EAHM), conhecendo sua estrutura fatorial e consistencia interna. Participaram 203 estudantes universitarios de uma instituicao publica de Joao Pessoa (PB), cuja idade media foi de 26 anos (DP = 6,84; amplitude de 17 a 26 anos), sendo a maioria do sexo feminino (59%). Estes responderam a EAHM e perguntas demograficas. A partir de uma analise de componentes principais, identificou-se uma estrutura com dois fatores que explicaram conjuntamente 51,7% da variância total, podendo ser nomeados como comportamentos desviantes (α = 0,90) e comportamentos satânicos (α = 0,90). Concluindo, tais achados se mostraram coerentes com a percepcao que as pessoas comumente tem deste estilo de musica, enfatizando pensamentos como abuso de drogas, ideacao suicida, comportamentos de risco e agressividade.
Smart search engine using artificial intelligence

Due to the increasing information on the Web it becomes very difficult for a single search engine to provide comprehensive Web coverage, thus increasing the difficulty for an average user to search information on the web. We have proposed an idea for smart Meta search engine which will have a more comprehensive coverage of the web by targeting different search engines for different search categories. The user's search query will be modified using a knowledge base and appropriate search engine will be selected. The results returned from these search engines will be merged and ranked. These results will be classified into various categories using a classification algorithm and then the result will be displayed sorted into categories. It will be beneficial to the user who has an obscure idea about the information he/she wanted to search.
A case of atypical light chain deposition disease--diagnosis and treatment.

Joining the outstanding original research and invited materials already appearing in the Clinical Journal of the American Society of Nephrology ( CJASN ), a new feature, Clinical Conferences, appears for the first time in this issue. This feature is designed to expand our emphasis on practical information for clinicians and is organized and edited by Ajay Singh of Brigham and Women's Hospital and by Charles Alpers of the University of Washington. We will periodically publish Clinical Conferences from academic health centers where expert clinicians discuss a particularly challenging case. This issue's inaugural Conference on light chain deposition disease is discussed by David Salant, Vaishali Sanchorawala, and Vivette D'Agati. This new Clinical Conference feature will supplement CJASN's published versions of the ClinicoPathologic Conference (CPC) and Nephrology Quiz that are presented each year at the annual meeting of the American Society of Nephrology. You will see these articles in subsequent issues. By providing these features, CJASN hopes to make analyses as well as diagnostic and therapeutic approaches by acknowledged experts accessible to clinicians. We sincerely hope that our readers enjoy this new feature as well as the annual CPC and Nephrology Quiz. CJASN 's entire editorial team would also like to thank the readership for their support of the Journal . We look forward to receiving feedback on the CJASN Clinical Conference. William M. Bennett, MD Harold I. Feldman, MD Mohamed H. Sayegh, MD The patient is a 70-yr-old retired schoolteacher who had been in good health until he was found to have asymptomatic proteinuria (approximately 1 g/24 h) on routine physical examination. He was mildly hypertensive, and serum creatinine was 1.2 mg/dl with a measured creatinine clearance of 78 ml/min. The patient's past medical history was significant for mild hypertension, hyperlipidemia, diet-controlled glucose intolerance (HbA1c 5.2), an intentional weight loss of 15 …
Heparin-Induced Thrombocytopenia

Review of 6,000 patient records from our laboratory showed 609 individuals who received continuous intravenous infusion heparin therapy for thromboembolic disease. 40/609 (6.5%) of these patients were found to have a platelet count of less than 150,000 cell/mm . Of this group, 34/40 (85%) exhibited thrombocytopenia prior to heparin therapy that was attributable to consumptive coagulopathy in 21/40 (52.5%), sepsis or malignancy in 11/40 (27.5%), and cimetidine or sulfisoxazole in 2/40 (5%). Heparin therapy had no adverse effect on the platelet count in these individuals, and the count returned to normal in surviving individuals if the underlying cause was successfully treated or the offending drug removed. Only 6/40 (15%) of the patients developed low platelet counts during the course of heparin therapy; this represents 6/609 (0.98%) of the population receiving heparin. The etiology of thrombocytopenia in 5/6 (83%) of the cases was traced to metastatic cancer (3), burn wound sepsis (1), and septic shock (1). Only 1/609 (0.16%) of these patients developed low platelet count that could be attributed to heparin. Thus, the incidence of heparin-induced thrombocytopenia is extremely rare in our hospital population.
New Formulation of Sustained Release Naloxone Can Reverse Opioid Induced Constipation Without Compromising the Desired Opioid Effects.

UNLABELLED An international double-blind randomized placebo controlled study evaluated the safety and efficacy of four doses of a new sustained release naloxone capsule to treat Opioid Induced Constipation (OIC). METHODS Forty patients taking opioids for noncancer related pain, and experiencing OIC, were randomized into 4 cohorts of 10 patients. A multiple ascending dose design was used to evaluate the safety and efficacy of 2.5 mg, 5 mg, 10 mg, and 20 mg naloxone sustained release (NSR) capsules vs placebo. Drug was given once-daily for 3 weeks followed by twice daily (bid) dosing between weeks 4 and 6. RESULTS The incidence of treatment emergent adverse events was highest in the placebo group. The incidence of adverse events among the four active treatment groups were similar. There were no serious adverse events. The number of severe events was low overall but highest in the placebo group. Significant improvements were seen in Spontaneous Bowel Movements with 5 mg, 10 mg, and 20 mg NSR capsules. Mean change in SBMs from baseline of 2.21 (P = 0.052), 2.37 (P = 0.032); 4.11 (P = 0.0005); 5.19 (<0.0001) was noted with NSR 2.5 mg, 5 mg, 10 mg, and 20 mg, respectively, when taken once daily, compared with 1.38 (P = 0.2) for patients on placebo therapy. No changes in subjective or objective measures of opioid withdrawal as measured by the Subjective Opioid Withdrawal Scale or Clinical Opioid Withdrawal Scale were observed. There was no increase in patient reported pain as measured daily using a visual analogue scale. CONCLUSIONS This Phase II study has shown that using a new sustained release formulation to deliver oral naloxone to the colon allows successful treatment of OIC without comprising the desired opioid effects.
Principal Boundary on Riemannian Manifolds

Abstract We consider the classification problem and focus on nonlinear methods for classification on manifolds. For multivariate datasets lying on an embedded nonlinear Riemannian manifold within the higher-dimensional ambient space, we aim to acquire a classification boundary for the classes with labels, using the intrinsic metric on the manifolds. Motivated by finding an optimal boundary between the two classes, we invent a novel approach—the principal boundary. From the perspective of classification, the principal boundary is defined as an optimal curve that moves in between the principal flows traced out from two classes of data, and at any point on the boundary, it maximizes the margin between the two classes. We estimate the boundary in quality with its direction, supervised by the two principal flows. We show that the principal boundary yields the usual decision boundary found by the support vector machine in the sense that locally, the two boundaries coincide. Some optimality and convergence properties of the random principal boundary and its population counterpart are also shown. We illustrate how to find, use, and interpret the principal boundary with an application in real data. Supplementary materials for this article are available online.
Measuring anisotropic muscle stiffness properties using elastography

Physiological and pathological changes to the anisotropic mechanical properties of skeletal muscle are still largely unknown, with only a few studies quantifying changes in vivo. This study used the noninvasive MR elastography (MRE) technique, in combination with diffusion tensor imaging (DTI), to measure shear modulus anisotropy in the human skeletal muscle in the lower leg. Shear modulus measurements parallel and perpendicular to the fibre direction were made in 10 healthy subjects in the medial gastrocnemius, soleus and tibialis anterior muscles. The results showed significant differences in the medial gastrocnemius (μ‖ =0.86 ± 0.15 kPa; μ⊥ = 0.66 ± 0.19 kPa, P < 0.001), soleus (μ‖ = 0.83 ± 0.22 kPa; μ⊥ = 0.65 ± 0.13 kPa, P < 0.001) and the tibialis anterior (μ‖ = 0.78 ± 0.24 kPa; μ⊥ = 0.66 ± 0.16 kPa, P = 0.03) muscles, where the shear modulus measured in the direction parallel is greater than that measured in the direction perpendicular to the muscle fibres. No significant differences were measured across muscle groups. This study provides the first direct estimates of the anisotropic shear modulus in the triceps surae muscle group, and shows that the technique may be useful for the probing of mechanical anisotropy changes caused by disease, aging and injury. Copyright © 2013 John Wiley & Sons, Ltd.