Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Cytotoxicity and Cellular Apoptosis Induced by Azo-Dyes (Methyl Orange and Malachite Green) and Heavy Metals (Cadmium and Lead) Using Nigella sativa L. (Black Cumin)

Dry seeds of Nigella sativa L. (Ranunculaceae) are exposed to azo-dyes [methyl orange (MO) and malachite green (MG)] and heavy metals [cadmium (Cd) and lead (Pb)] following impregnation of a filter paper for 12 days at an interval of 48 h. Cytotoxicity on mitotic index, types, and frequency of cytological abnormalities and apoptotic cell death induced by the test materials are assessed in relation to control. All the studied environmental pollutants were found to reduce germination and growth, inhibit cell division, enhance cytological aberrations and cause apoptotic cell death. Fluorescence activated cell sorting (FACS) analyses not only reveal apoptosis but also induced metabolic peak shifting and polyploid cell formation at late G2 phase. Results suggest that heavy metals (Pb>Cd) show more toxicity than azo-dyes (MG>MO). The objective of the investigation is to predict safety dose for commercial exploitation of the studied azo-dyes and heavy metals. From the standpoint of which the employed low doses of the studied environmental pollutants are found to induce cytotoxicity affecting germination and growth in seedlings of N. sativa.
Ozone treatment in a wind tunnel for the reduction of airborne viruses in swine buildings

Abstract Ozone is effective against bacteria and viruses although its influence over bioaerosols is understudied and could be useful particularly in agricultural buildings such as swine confinement buildings. Ozone treatment of air within ventilation plenum could be applied for biosecurity purposes during the quarantine of incoming animals. In this study, a bacteriophage (PhiX174) was used as a surrogate for eukaryotic viruses in nebulization experiments inside a wind tunnel to study the factors that affect ozone’s efficacy to reduce the virus. A tunnel system was installed in the workshop of a swine building with controlled relative humidity (40% and 80%), ozone concentration (0, 0.3, 0.6, 0.9, 1.2, 1.5, and 1.8 ppm), and exposure time (up to approximately 6 min) of PhiX174 nebulized. Although there was no effect of ozone on phage genomes, culturable phages were inactivated. There was a reduction of PhiX174 infectious ratios with increasing ozone concentrations and stronger effects of ozone observed at 80% relative humidity. The data suggests the potential success of a wind tunnel and ozone air treatment to control infectious viruses emitted from swine barns or quarantine buildings. Copyright © 2020 American Association for Aerosol Research
In vitro RUMEN FERMENTATION CHARACTERISTICS, METHANE PRODUCTION AND RUMEN MICROBIAL COMMUNITY OF TWO MAJOR Acacia SPECIES USED IN SAHELIAN REGION OF BURKINA FASO

<p><em>Acacia</em> <em>nilotica </em>var adansonii (Guill. et Perr.) O. Ktze and <em>Acacia raddiana</em> (Savi) species are local ressources important to feed animals in Sahelian area of Burkina Faso. Thus, this experiment was to investigate the <em>in vitro</em> effect of both <em>Acacias </em>on ruminal fermentation, CH<sub>4</sub> production and rumen microbial community using a semi-automatic system. In all experiments, 25 mL of the inoculum solution was incubated with 50 mL of buffered rumen fluid at 39 °C and gas production was measured at 2, 4, 8, 12 and 24 h. The results show that <em>A. nilotica</em> was rich in condensed tannins and fiber content compared to <em>A. raddiana</em> which was rich in total tannins. <em>A. raddiana </em>treatment presented greater degradability of organic matter and<em> </em>lower CH<sub>4</sub> production compared to <em>A. nilotica</em> and control group (P<0.05). In addition, methanogenic archaeal were significantly lower in <em>A. raddiana</em> associated with increased fungal communities abundance compared to <em>A. nilotica</em> (P<0.05), but no effects was observed on rumen bacteria <em>R. flavefaciens</em> and <em>F. succinogenes</em> (P>0.05). We conclude that <em>A. nilotica</em> leaves showed negative effect on ruminal fermentation due to high fiber and CT content, and <em>A. raddiana</em> could be an interesting plant to increase fiber digestion and reduce CH<sub>4</sub> production <em>in vitro. </em></p>
The role of asperities in seismicity frequency-magnitude relations using the TREMOL v0.1.0. The case of the Guerrero-Oaxaca subduction zone, México

Abstract. Seismicity and magnitude distributions are fundamental for any type of seismic hazard analysis. The Mexican subduction zone along the Pacific Coast is one of the most active seismic zones in the world. Some peculiar characteristics of the seismicity have been observed for a subregion of the subduction regime, which has been named SUB3 in a recent seismotectonic regionalization of the country, suggesting that the observed simplicity of this source arises from the rupturing of single asperities. In this work, we numerically test this hypothesis using the TREMOL (sThochastic Rupture Earthquake MOdeL) v0.1. 0 code. As test cases, we choose four of the most significant events (6.5
On an ongoing corporate dividend dialogue: Do external influences also matter in dividend decision?

Abstract Dividend policy is among the most debated topics in corporate Finance. Determinants of corporate dividend, most commonly firm specific determinants, have attracted much attention of the researchers. This paper mainly investigates the external determinants of dividend policy in Tanzania. The study also checks the influence of firm-specific factors that determine dividend decision of non-financial firms listed in Dar es Salaam Stock Exchange using a panel data analysis for a period 2008–2017. The paper reports that gross domestic product (GDP) and inflation have both statistically negative signifant relationship with the firm payout ratio. This implies that in a country where GDP is high, firms are less likely to consider paying dividends. During high GDP levels, the economic environment is potentially conducive for potential investment, and therefore re-investing the corporate profit is relatively a wise decision than distributing it back to owners as dividend. Also in an inflationary environment, funds generated are often are not sufficient to replace a firm’s assets as they become obsolete. Under these circumstances, a firm may be forced to retain a higher percentage of earnings to maintain the earning power of its asset base that is why during this time less dividend is expected by shareholders. Furthermore, the paper reports that firm-specific factors such as profitability, liquidity, firm size, leverage and firm growth are also influencial in determining corporate dividend policy. More specifically, large-sized firms, highly profitable firms are more likely to consider paying dividend. However, payment of dividend will all depend on whether the firm is liquid enough to afford that. On the other hand, high-growth and leveraged firms would not probably consider paying dividend, and will therefore, save money to finance their expansion and honor their debt obligations.
Network-targeted, multi-site direct cortical stimulation enhances working memory by modulating phase lag of low frequency oscillations

Working memory, an important component of cognitive control, is supported by the coordinated activation of a network of cortical regions in the frontal and parietal cortices. Oscillations in theta and alpha frequency bands are thought to coordinate these network interactions. Thus, targeting multiple nodes of the network with brain stimulation at the frequency of interaction may be an effective means of modulating working memory. We tested this hypothesis by identifying regions that are functionally connected in theta and alpha frequency bands and intracranially stimulating both regions simultaneously in participants undergoing invasive monitoring. We found that in-phase stimulation resulted in improvement in performance compared to sham stimulation. In contrast, anti-phase stimulation did not affect performance. In-phase stimulation resulted in decreased phase lag between regions within working memory network while anti-phase stimulation resulted in increased phase lag suggesting that shorter phase lag in oscillatory connectivity may lead to better performance. The results support the idea that phase lag may play a key role in information transmission across brain regions. More broadly, brain stimulation strategies that aim to improve cognition may be better served targeting multiple nodes of brain networks.
English for Medical Purposes Should Not Be Silent: Promoting Intercultural Communication of EMP in China

With the rapid growth of academic cooperation of medical science between China and the world, there has been an increasing demand of intercultural communication in English for medical purposes (EMP) in China. For a long time, people in China have attached importance to reading and writing in EMP while neglecting the listening and speaking ability of medical students. The aim of this paper is to demonstrate the situation of intercultural communication between Chinese doctors and foreign patients and explain the significance of verbal communication in EMP. Based on data collected from discourse cases in Chinese medical settings, this paper demonstrates that EMP in China should pay more attention to the three critical elements: medical jargon, contextualized language, and cultural difference, and analyzes the significance of three elements through qualitative research. This paper also explores underlying reasons of intercultural communication failure between Chinese doctors and foreign patients, and helps to develop the idea that EMP teaching in China should not be silent.
Myelodysplastic Syndrome / Secondary Acute Myeloid Leukemia: role of the allogeneic hematopoietic stem cell transplantation

Secondary Acute Myeloid Leukemia (s-AML) refers to the development of leukemia after cytotoxic therapy, immunosuppressive therapy, radiation or an antecedent hematological disorder, such as Myelodysplastic Syndrome (MDS). A s-AML corresponds to 10% to 30% of AML cases and is defined by the presence of at least 20% of blast cells, representing a category of disease with a poor prognosis. Allogeneic hematopoietic stem cell transplan­tation (Allo-HSCT) is the only option with curative potential for patients with s-AML, but recurrence after HSCT emerges as a frequent cause of treatment failure and course with high mortality. We report the case of a patient with s-AML after MDS, who underwent HSCT due to refractoriness to other treatments, recovering the bone marrow with dysplasia, be­ing classified as AREB1.
A Transmembrane Single-Polypeptide-Chain (sc) Linker to Connect the Two G-Protein–Coupled Receptors in Tandem and the Design for an In Vivo Analysis of Their Allosteric Receptor- Receptor Interactions

A transmembrane (TM) single-polypeptide-chain (sc) linker can connect two G-protein– coupled receptors (GPCRs) in tandem. The priority of a gene-fusion strategy for any two class A GPCRs has been demonstrated. In the striatal function, dopamine (DA) plays a critical role. In the striatum, how the GPCR for adenosine, subtype A2A (A2AR), contributes to the DA neurotransmission in the “volume transmission”/dual-transmission model has been studied extensively. In addition to the fusion receptor, i.e., the prototype scA2AR/D2R complex (the GPCR for DA, subtype D2), several types were created and tested experimentally. To further elucidate this in vivo, we designed a new molecular tool, namely, the supermolecule scA2AR/D2R. Here, no experiments on its expression were done. However, the TM linker to connect the nonobligate dimer as the transient class A GPCR nanocluster that has not been identified at the cell surface membrane deserves discussion through scA2AR/D2R. Supramolecular designs, are experimentally testable and will be used to confirm in vivo the functions of the two GPCRs interactive in such a low specific signal to the nonspecific noise (S/N) ratio in the neurotransmission in the brain. The sc also has, at last, become straightforward in the field of GPCRs, similar to in the field of antibody.
A REVIEW ON ANTIFERTILITY ACTIVITY OF PLANTS OF CHAMBAL RIVERINE

Indian sub-continent showing very high diversity in both ecological and geographical aspects. In India, medicinal plants are widely distributed in different climatic conditions and are abundant in a mountainous region or riverine area. In this review, are being discussed anti-fertility properties of Indiaâ€™s well-known Chambal riverine flora. This area is rich in many medicinal plants as Acyranthus aspera, Acacia catechu, Nelumbo nucifera, Nyctanthes arbortristis, Mimosa pudica, Adhatoda vasica, Calotropis gigantea, Pergularia daemia, Vicoa indica, etc. These plants possess potential antifertility activity and many phytoconstituents, responsible for antispermatogenic, anti-implantation, antiovulatory, antiandrogenic, and many more activities. Hence, this review comprises a brief study of some medicinal plants found in Chambal riverine and showing the comprehensive antifertility activity of those plants.
Comparative Analysis of Some Proteins Encoded by Genes Significantly Related to Diabetes

Aims: The study was performed with the aim of understanding the role of protein structures encoded by a few of those genes which show the most significant alterations in their expression under normal versus diabetic conditions. Study Design: The study involved identifying a few relevant genes and analysis of various components of their protein structures. Methodology: Nine genes were shortlisted based on the extensive search of available secondary data. The structures of proteins encoded by them were generated Conclusion: These preliminary observations are indicative of probable protein-protein interactions which may contribute towards disease pathology. Further studies on interactions between these domains of various proteins may throw light on this aspect. Since diabetes incidences are increasing exponentially across the world, further detailed analysis of the individual components of the protein structures may help in obtaining a better understanding of the molecular mechanisms that are involved in this disease. This study substantiates those findings which have reported the importance of genetics in diabetes.
The dark side of bright traits: How context cues misdirect facets of conscientiousness

PurposeThe authors test the proposition that there are dark sides to conscientiousness that are revealed when examining lower-level facets. The authors propose that potentially dysfunctional behavior is triggered by context cues that are relevant to duty versus achievement striving.Design/methodology/approachThe authors conducted two laboratory experiments designed to test how context cues that are specific to duty and achievement striving influence the relationship between these facets and quality versus quantity dimensions of task performance.FindingsIn Study 1, the authors found that normative quality cues led to a stronger relationship between duty and discretionary quality performance. In Study 2, achievement striving was associated with lower levels of quality performance in the presence of competitive feedback cues.Research limitations/implicationsThe findings illustrate that the dark side of duty and achievement striving emerges in two ways. First, when there is normative pressure for quality, dutiful individuals are apt to sacrifice efficiency. Second, when there is competitive feedback, achievement striving individuals focus on performance standards at the detriment of quality.Practical implicationsThe findings point to the importance of precision and specificity when using personality measures for staffing. Equally important is the informational content of cues conveyed by the social, task and organizational context, in leveraging the impact of personality in the workplace.Originality/valueThis paper clarifies the dark side and bright side contradiction of conscientiousness, adding to the growing literature on unique and often competing consequences of duty and achievement striving. The authors also draw attention to the importance of the content of contextual cues, in trait activation of personality.
Meat and Muscle BiologyTM Introduction

An experiment was conducted to determine the effects of Ralco’s Microfused Essential Oils (MEO) on growth, jejunal histology, and meat quality of coccidiosis-challenged broilers. Day old broilers (n = 768; 64 pens; 12 broilers/pen) were randomly allotted to 1 of 5 dietary treatments fed in 4 phases: starter (d0–16), grower (d17–27), finisher (d28–34), and withdrawal (d35–41). Diets were a corn-soybean meal basal diet (CON), CON+BMD50/Coban90 at 55/121, 250/550, 250/495 and 0 mg/kg (ANTI), CON+MEO at 375, 250, 125, and 100 mg/kg (MEOD), CON+MEO at constant 500 mg/ kg (MEO500), and CON+MEO at constant 250 mg/kg (MEO250). Broilers were offered a 10X dose of a coccidiosis vaccine on d 3, 15, 22, and 29. On d 14, jejunal histology was measured. Two broilers per pen were harvested on d 41 and breast pH was measured. Rancidity compounds (TBARS) were measured on whole breasts at d 7 postmortem and ground thighs on d 0, 3, 5, and 7 postmortem. Overall, MEO250-fed broilers had a tendency for greater gain over CON-fed (63.6 vs. 61.3 ± 0.87 g; P < 0.08). MEOD-fed broilers tended to have greater villus height compared to MEO500-fed (806.6 vs. 716.3 ± 27.7 μm; P = 0.09. No differences were observed for pH or TBARS of breasts (P > 0.05). There were differences in L*, a*, and b* color values of breasts and there was an interaction for color values of thighs. ANTI, MEO500, and MEO250 had decreased TBARS values for thighs compared to CON at d 7 postmortem (P ≤ 0.05). Overall, growth performance of MEO250 was not different than ANTI during peak challenge (P > 0.05). MEO250 could improve growth performance and meat quality when broilers are subjected to a coccidiosis disease challenge.
Real-life Lernaean Hydras: a practical activity about the effects of oxygen concentration on regenerative capabilities of planarians

ABSTRACT Changes in environmental conditions can have a profound impact on organismal processes. For aquatic organisms, changes in dissolved oxygen concentration can have major repercussions, notably for physiological processes that have high long-term energetic costs and are more likely to rely on aerobic metabolic pathways. Here we propose a simple college or university-level low-cost laboratory activity that addresses the effect of differences in oxygen concentration on an important physiological property of planarian flatworms: their regeneration capacity. Students were asked to perform measurements and statistically compare the efficacy of the regeneration process between planarians kept in normoxic conditions and others kept in hypoxic conditions. The activity was evaluated by asking students to produce a short laboratory report with all of the sections that a scientific article generally comprises. This hands-on experiment has the benefit of going beyond how planarians are traditionally used in biodiversity classes (i.e. basic anatomy of flatworms) by combining behavioural, physiological and environmental observations while investigating the effects of an environmental variable on the regeneration response. We would further encourage professors to expand even more upon this framework by providing the students with an opportunity to actively engage in all steps inherent to the scientific process.
Comparative Analysis of the Performance of Network Intrusion Detection Systems: Snort, Suricata and Bro Intrusion Detection Systems in Perspective

There exists a number of intrusion detection systems particularly those that are open-source. These intrusion detection systems have their strengths and weaknesses when it comes to intrusion detection. This work compared the performance of open-source intrusion detection systems namely Snort, Suricata and Bro. The comparative analysis of these intrusion detection systems was carried out to present an independent view of their performance regarding intrusion detection. It took into consideration their effectiveness in detecting Denial of Service, probe, scan, User-to-Local and User-to-Root attacks and also detection accuracy in terms of false positive, false negative and true positive alarms. All three IDS were installed on virtual machines with the same specification with a network switch linking them to a target server in a virtual environment using maximum Ethernet speed of 5Gigabits per second (Gbps). False positive, false negative and true positive alarm rates of Snort, Suricata and Bro IDSs have also been determined in this work through the injection of normal and malicious attacks such as DoS, probe, scan and user-to-root. Transmission Control Protocol, User Datagram Protocol and Internet Control Message Protocol were the normal traffic used.
Étude des gènes de fusion MLL dans les leucémies aigues humaines

iv Table des matières . v Liste des tableaux . vii Liste des figures . viii Liste des abréviations . ix Remerciements . xiii I. Introduction . 1 1. L'Hématopoïèse . 1 a) Définition . 1 b) Les cellules souches hématopoïétiques (CSH) . 2 c) Les marqueurs des cellules hématopoïétiques humaines . 4 d) Régulation de l’hématopoïèse . 5 2. Les leucémies aigues . 10 a) Leucémogénèse . 10 b) Classification des leucémies . 12 c) Incidence . 16 3. Le gène MLL . 18 a) Le gène MLL dans l’hématopoïèse . 18 b) Les réarrangements chromosomiques impliquant MLL . 22 4. Les leucémies MLL . 25 a) Les gènes de fusion MLL dans les leucémies aigues . 25 b) L’origine prénatale des leucémies . 28 5. Modèles in vivo de leucémies MLL . 29 6. Le séquençage à haut débit . 30 a) Principe . 31 b) Son apport et ses limites . 32 7. Objectifs du projet de recherche . 34 II. Matériel et méthodes . 35
Design and experimental verification on a deformable underwater solar concentrator with bi‐layer film structure

This paper presents a deformable underwater solar concentrator (DUSC) which is innovatively designed to converge underwater radiation. The concentrator is a hollow cylinder‐like structure with elastic films covering the two flat ends. When it is put underwater, the elastic films will concave inwards and form spherical convex lenses. The design scheme and concentrating peculiarities of the concentrator were analysed. Optical simulation and experimental verification were carried out on a concentrator sample with diameter of 200 mm. It is found that f‐number (the ratio of focal length to radius) and concentration ratio will decrease when enlarge the films' deformation ratio. The effective deformation ratio is found to be less than 0.45 to avoid total reflection. Optical simulation under condition of visible spectrum with considering the solar parallax indicates that the maximum energy density of the focus occurs when deformation ratio is 0.3, and f‐number is around 3.5. During the tilt incidence, the shape of focus and energy density value will not vary distinctly until the tilt incident angle is above 10°. The average experimental optical efficiency of the DUSC is about 60% when incident angle is within 10°. This work is likely to provide a new perspective for utilizing solar energy underwater.
Drug loading of mesoporous silicon particles

Author Sanna Ojanen Title Drug loading of mesoporous silicon particles Faculty Faculty of Technology Degree programme Chemical Technology Year 2008 Master’s Thesis, Lappeenranta University of Technology 111 pages, 18 figures, 12 tables and 4 appendices Examiners Prof. Juha Kallas Docent Marjatta Louhi-Kultanen