Miracle-dz/UniFAR-FTUs huggingface dataset:
Epidural Bupivacaine-Morphine Analgesia versus Patient-controlled Analgesia following Abdominal Aortic Surgery: Analgesic, Respiratory, and Myocardial Effects

Background The efficacy and effects of epidural analgesia compared with patient-controlled analgesia (PCA) have not been reported in patients undergoing major vascular surgery. We compared the effects of epidural bupivacaine-morphine with those of intravenous PCA morphine after elective infrarenal aortic surgery. Methods Forty patients classified as American Society of Anesthesiologists physical status 2 or 3 received general anesthesia plus postoperative PCA using morphine sulfate (group PCA; n = 21) or general anesthesia plus perioperative epidural morphine - bupivacaine (group EPI; n = 19) during a period of 48 h. During operation, EPI patients received 0.05 mg/kg epidural morphine and 5 ml 0.25% bupivacaine followed by an infusion of 0.125% bupivacaine with 0.1% morphine (0.1 mg/ml); group PCA received 0.1 mg/kg intravenous morphine sulfate. Continuous electrocardiographic monitoring (V4 and V5 leads) was performed from the night before surgery until 48 h afterward. Respiratory inductive plethysmographic data were recorded after tracheal extubation. Visual analog pain scores at rest and after movement were performed every 4 h after extubation. Results Nurse-administered intravenous morphine and time to tracheal extubation were less in group EPI, as were visual analog pain scores at rest and after movement from 20 to 48 h. Complications and the duration of intensive care unit and hospital stay were comparable. There was a similar, low incidence of postoperative apneas, slow respiratory rates, desaturation, and S-T segment depression. Conclusions Epidural morphine-bupivacaine is associated with reduced early postoperative intravenous opioid requirements, more rapid tracheal extubation, and superior analgesia after abdominal aortic surgery, with comparable respiratory effects.
The Honeywell Experimental Distributed Processor - an Overview

The Honeywell Experimental Distributed Processor (HXDP) is a vehicle for research in the science and engineering of processor interconnection, executive control, and user software for a certain class of multiple-processor computers which we call "distributed computer" systems. Such systems are very unconventional in that they accomplish total system-wide executive control in the absence of any centralized procedure, data, or hardware. The primary benefits sought by this research are improvements over more conventional architectures (such as multiprocessors and computer networks) in extensibility, integrity, and performance. A fundamental thesis of the HXDP project is that the benefits and cost-effectiveness of distributed computer systems depend on the judicious use of hardware to control software costs.
Novel direct torque control (DTC) scheme with fuzzy adaptive torque-ripple reduction

Investigations were carried out on a novel direct torque control system, which not only reduces the undesirable torque ripple by up to 98% by means of introducing a modulation between the selected active state and a zero state, but also maintains constant switching frequency. Additionally, this two-state modulator is fuzzy adaptive and may be applied to any induction motor. Simulation and the results of experiment illustrate the operation and performance of the proposed fuzzy-logic-based controller.
Recycling Ambient Wi-Fi Signals for Low Energy Wake-Up of Wireless Sensors

In this letter, waking-up wireless sensors is achieved by solely relying on existing ambient radio frequency signals from commercial Wi-Fi routers. The wake-up is accomplished based on the captured Wi-Fi signal that is received by an antenna and then fed into a rectifier circuit. A novel packet injection algorithm is developed to enable the rectifier to efficiently convert the captured Wi-Fi signal into a dc power. This algorithm can be implemented on any commercial router with no modifications to the router's hardware or protocol stack and without compromising the performance of the Wi-Fi network. The design is experimentally validated under controlled conditions.
Clinical and radiographic characteristics of single-tooth replacements preceded by local ridge augmentation: a prospective randomized clinical trial.

OBJECTIVES To assess in a randomized-clinical trial the influence of three augmentation techniques (chinbone with or without a Bio-Gide membrane and Bio-Oss with a Bio-Gide membrane) on the clinical and radiographic characteristics of hard and soft tissues around implants and adjacent teeth in the reconstructed maxillary anterior region, up to 1 year after functional loading. MATERIALS AND METHODS Ninety-three patients requesting single-tooth replacement and presenting with a horizontal (bucco-palatinal) bone deficiency were included. After augmentation, 93 ITI-Esthetic(Plus) implants were placed. Clinical variables, standardized photographs and radiographs were analysed to assess the impact on the levels of the marginal gingiva (MGL) and marginal bone (MBL) around implants and adjacent teeth, viz at pre-augmentation, pre-implantation (TPI) and 1 (T(1)) and 12 (T(12)) months after final crown placement. RESULTS Implant survival was 97.8%. No significant differences were observed in the treatment outcomes of the three augmentation modalities. Combining the three modalities, a slight but significant increase in the implants approximal pocket depth was found between T(1) and T(12). Approximal bone loss at the implant between T(1) and T(12) was 0.14 +/- 0.76 mm (mesial) and 0.14 +/- 0.47 mm (distal); the approximal MGL slightly increased (mesial: 0.24 +/- 0.46 mm, distal: 0.25 +/- 0.66 mm), and the buccal MGL decreased (0.11 +/- 0.61 mm). Bone loss at the adjacent teeth, although minor, was significant between TPI and T(1). No correlations were observed in changes of MBL and MGL. CONCLUSIONS None of the three applied augmentation technique procedures influenced the characteristics of the MGL and MBL or the implant survival of single-tooth replacements. Peri-implant hard and soft tissues were very stable in the first year after loading.
Dietary Omega-3 Fatty Acids and Depression in a Community Sample

Abstract To evaluate the association between omega-3 polyunsaturated essential fatty acids and depression, data regarding prevalence rates of self-reported depression and median daily dietary intakes of these fatty acids were obtained from an age-stratified, population-based sample of women (n=755; 23-97 year) in the Barwon Statistical Division of south-eastern Australia. A self-report questionnaire based on Diagnostic and Statistical Manual-IV criteria was utilised to determine 12-month prevalence rates of depression in this sample, and data from biennial food frequency questionnaires examining seafood and fish oil consumption over a 6-year period were examined. Differences in median dietary intakes of omega-3 fatty acids between the depressed and non-depressed cohorts were analysed and results were adjusted for age, weight and smoking status. No significant differences in median intakes were identified between the two groups of women (median, interquartile range; depressed=0.09 g/day, 0.04-0.18 versus non-depressed=0.11 g/day, 0.05-0.22, p=0.3), although overall average intakes of omega-3 fatty acids were lower than recommended and rates of depression within this sample higher than expected, based on previous data. Further research that takes into account ratios of omega-6 to omega-3 polyunsaturated essential fatty acids, as well as other dietary sources of omega-3 fatty acids, is warranted.
EEG Derivations Providing Auditory Steady-State Responses With High Signal-to-Noise Ratios in Infants

Objective: To identify EEG derivations that yield high signal-to-noise ratios (SNRs) of the auditory steady-state response (ASSR) in infants aged 0 to 5 months. Design: The ASSR was recorded simultaneously from 10 EEG derivations in a monopolar montage in 20 sleeping infants. Stimuli were tones of 0.5 or 2 kHz that were 100% amplitude modulated and 20% frequency modulated, presented at 65 dB SPL for 4.4 minutes in either the right or the left ear. An amplitude modulation frequency of 90 Hz (left ear) or 94 Hz (right ear) was used. From the 10 measured monopolar derivations, all 45 bipolar derivations were calculated mounting up to 55 EEG derivations. EEG derivations were selected in the preferred set if they had the largest SNRs within subjects and if they were obtained significantly more frequently across subjects than was expected by chance (Monte Carlo simulation and Wilcoxon signed ranks test). Results: The preferred derivations are both mastoids ipsilateral to the stimulated ear with Cz as common reference. These derivations improved SNRs compared with each of several conventional EEG derivations (excluding the preferred derivations) between 16 and 69% (500 Hz, left ear), 9 and 132% (500 Hz, right ear), 31 and 193% (2 kHz, left ear), and 3 and 105% (2 kHz, right ear). In contrast to results reported earlier for adults, high SNRs were not found at the inion-Cz derivation in these infants. Conclusions: High SNRs were obtained in infants aged younger than 6 months if the ASSR was recorded from the mastoids ipsilateral to the ear of stimulation referenced to Cz.
Um método de identificação de fontes de vibração em vigas.

In this work, we try to solve the direct problem of the clamped-clamped EulerBernoulli beam equation, with zero initial conditions. We study the inverse problem of the beam, consisting in the identification of the source of vibration, shaped as an element in L, using as data the speed from an arbitrary point of the beam, during a time interval arbitrarily small. The relevance of this work in Engineering, for example, is in the identification of structural damage in beams.
Effect of delayed colostrum collection on colostral IgG concentration in dairy cows.

OBJECTIVE To determine the effect of timing of first-milking colostrum collection on colostral IgG concentration. DESIGN Prospective study. ANIMALS 13 healthy Holstein cows. PROCEDURES All calvings were observed. After parturition, calves were not allowed to suckle and were separated from the dam. Colostrum was collected from a single randomly selected quarter at 2, 6, 10, and 14 hours after parturition until all 4 quarters were sampled. Colostral IgG concentration was determined via radial immunodiffusion. RESULTS Mean colostral IgG concentration was 113, 94, 82, and 76 g/L at 2, 6, 10, and 14 hours after calving, respectively. Colostrum collected 6, 10, and 14 hours after calving had significantly lower IgG concentrations than did colostrum collected 2 hours after calving. Mean colostral IgG concentration at 14 hours after calving was significantly lower than that at 6 hours after calving. Cows in their third or greater lactation had mean colostral IgG concentrations 2 hours after calving (132 g/L) that were greater than the first and second lactation cows (mean, 95 and 100 g/L, respectively). CONCLUSIONS AND CLINICAL RELEVANCE Results indicate that early or immediate colostrum collection from dairy cows will maximize colostral IgG concentration. Adjustment of routine dairy farm management procedures may be required to maximize colostrum quality and minimize prevalence of failure of passive transfer in dairy calves.
Forward genetic screen of mouse reveals dominant missense mutation in the P/Q‐type voltage‐dependent calcium channel, CACNA1A

Dominant mutations of the P/Q‐type Ca2+ channel (CACNA1A) underlie several human neurological disorders, including episodic ataxia type 2, familial hemiplegic migraine 1 (FHM1) and spinocerebellar ataxia 6, but have not been found previously in the mouse. Here we report the first dominant ataxic mouse model of Cacna1a mutation. This Wobbly mutant allele of Cacna1a was identified in an ethylnitrosourea (ENU) mutagenesis dominant behavioral screen. Heterozygotes exhibit ataxia from 3 weeks of age and have a normal life span. Homozygotes have a righting reflex defect from postnatal day 8 and later develop severe ataxia and die prematurely. Both heterozygotes and homozygotes exhibit cerebellar atrophy with focal reduction of the molecular layer. No obvious loss of Purkinje cells or decrease in size of the granule cell layer was observed. Real‐time polymerase chain reaction revealed altered expression levels of Cacna1g, Calb2 and Th in Wobbly cerebella, but Cacna1a messenger RNA and protein levels were unchanged. Positional cloning revealed that Wobbly mice have a missense mutation leading to an arginine to leucine (R1255L) substitution, resulting in neutralization of a positively charged amino acid in repeat III of voltage sensor segment S4. The dominance of the Wobbly mutation more closely resembles patterns of CACNA1A mutation in humans than previously described mouse recessive mutants (tottering, leaner, rolling Nagoya and rocker). Positive‐charge neutralization in S4 has also been shown to underlie several cases of human dominant FHM1 with ataxia. The Wobbly mutant thus highlights the importance of the voltage sensor and provides a starting point to unravel the neuropathological mechanisms of this disease.
[Needle-tract seeding after ultrasound-guided puncture of hepatocellular carcinoma. A study of 150 patients].

OBJECTIVES To study the frequency of tumor seeding after percutaneous biopsy of hepatocellular carcinoma and to evaluate the impact on long-term survival. METHODS Records of 150 patients with cirrhosis who underwent ultrasound-guided aspiration biopsy for hepatocellular carcinoma between 1989 and 1996 were reviewed in June 1998. Liver transplantation was performed in 7 patients. One to three needle passes were performed with 18 to 20 gauge needles. Follow-up included regular clinical examinations and ultrasonography or computerized tomography. RESULTS Four cases (2.66%) of subcutaneous metastasis were noted at the needle insertion site; none in transplanted patients. All patients had viral cirrhosis, Okuda class I. Nodules were detected 4, 12, 22 and 24 months after biopsy. The second patient is alive 24 months after tumor seeding. For other patients, survival time was 4, 24 and 60 months respectively, without local tumor extension after surgical resection or radiotherapy. During a mean 11.8 months of follow-up, 127 patients died without tumor seeding. Eleven patients are still being followed and have no signs of needle tract implantation of hepatocellular carcinoma (mean follow-up 34.7 months). CONCLUSION The prevalence of tumoral seeding after percutaneous biopsy of hepatocellular carcinoma was 2.66%, which is higher than in previous studies. After liver transplantation, no evidence of needle tract seeding was identified. Survival did not seem to be influenced by local evolution.
The EU E-Privacy Directive: A Monstrous Attempt to Starve the Cookie Monster?

The development of the information society is characterized by the introduction of new electronic services available through different types of technologies and devices. Publicly available electronic communications services create new possibilities for users, governments and businesses. However, at the same time, these services have large capacities and possibilities for processing personal data. For instance, one of the technologies that are crucial in the functioning of the Internet, so-called ‘cookies’, are used to track an individual’s movements on a website and even among different websites, and can be used to store information that the individual supplies to another website including his name, address, credit card number, etc. This is of course of great advantage to advertisers who can create profiles of an individual and target their advertisements to match
Art expertise: a study of concepts and conceptual spaces

An aesthetic experience is a complex cognitive process, the nature and outcome of which depend upon the perceiver’s concepts and expertise (Leder, Belke, Oeberst, & Augustin, 2004). The present study aimed to find out more about the role of expertise in the experience of contemporary art. By combining a natural grouping task and correspondence analysis we compared a group of art experts with a group of non-experts as to the concepts they applied to a set of contemporary artworks and the general dimensions underlying their perception and interpretation of the works. There were marked parallels between both groups, pointing to general characteristics of aesthetic experiences. Still, the results support the hypothesis that experts process artworks more in relation to style, whereas non-experts refer to criteria such as personal feelings.
Circumvention of tamoxifen resistance by the pure anti‐estrogen ICI 182, 780

Both primary and acquired resistance to the growth‐inhibitory effects of anti‐estrogens (e.g., tamoxifen) limits the clinical usefulness of these drugs in the treatment of breast cancer. The new, steroidal anti‐estrogen ICI 182,780 was tested for its ability to inhibit the proliferation of a tamoxifen‐resistant variant of the parental MCF‐7 human breast‐cancer cell line. Two cell lines cloned from the MCF‐7 line were used for these experiments: a tamoxifen‐sensitive line, MCF 5‐21, and a tamoxifen‐resistant line, MCF 5‐23. Compared with tamoxifen, ICI 182,780 appeared to be 150 and 1540 times more effective in inhibiting cell growth in the 5‐21 and 5‐23 sub‐lines respectively. ICI 182,780 completely circumvented tamoxifen resistance at a concentration of (5 to 10) × 10−9 M in this model. Based on IC50 concentrations, the 5‐23 line was 22‐fold more resistant to tamoxifen than the 5‐21 line, but only 2‐fold more resistant to ICI 182, 780, reducing relative resistance by 10‐fold in the resistant line. There were no differences in ER parameters between the 2 lines. ER numbers/cell were: 40500 and 34800 and the KD 0.48 and 0.15 × 10−9 M in the 5‐21 and 5‐23 cells respectively. In the 5‐23 cells, the concentrations of ICI 182, 780 and tamoxifen resulting in a 50% inhibition of 3 H‐estradiol binding were 2.3 × 10−8 M and 1 × 10−6 M, respectively (cf. estradiol 0.89 × 10−9 M). Thus, one potential mechanism for the increased effectiveness of ICI 182,780 may relate to the increased affinity of this drug for the estrogen receptor as compared with tamoxifen.
Acellular Dermis as a Dermal Matrix of Tissue Engineered Skin Substitute for Burns Treatment

The current trend of burn wound care has shifted to a more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various etiologies. At present, there is no ideal skin substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesized on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. The biological skin substitutes may allow the construction of a more natural new dermis and allow excellent reepithelialization characteristics due to the presence of a basement membrane. Acellular dermal scaffold are one of the types of biological skin substitutes which has the extracellular matrix (ECM) almost like the normal skin extracellular matrix. For regeneration and healing of deep burn wound, ECM plays a very important role in rapid healing with minimum scar. Although some acellular dermis based products are available in foreign market, their prohibitive high cost prevents the Indian patient population to use it. Hence, this Method was designed to prepare an acellular dermis, indigenously, suitable for clinical application. NaOH method was used to standardize the decellularization method. In our observation, six weeks of decellularization was sufficient to completely decellularize the skin as confirmed by H&E Staining. Also, it was found out to be biocompatible by cell culture assay.
Percutaneous valve repair and replacement: the frontier of valve disease treatment.

The percutaneous treatment of mitral stenosis using balloon valvuloplasty is a reality. However, in Western countries there is only a low incidence of rheumatic valvular disease. Thus, attention is now focused on percutaneous, transcatheter approaches that will allow wider ranging treatment of pulmonic, aortic and mitral valve disease. These new approaches should result in percutaneous technologies that will allow replacement of pulmonic and aortic valves for both stenosis and regurgitation, repair of mitral regurgitation, and possibly even replacement of the mitral valve. Pulmonic and aortic valve replacement are already being studied in safety and efficacy trials in Europe. Investigators using percutaneous mitral valve repair will soon complete a Phase I US trial and the technology will be studied in a Phase II randomized trial. Patient care options for valvular heart disease are rapidly changing. 'Potential percutaneous replacement of the mitral valve still faces many practical hurdles, but sooner or later they will be overcome. '
Oral health‐related quality of life and risk factors associated with traumatic dental injuries in Brazilian children: A multilevel approach

BACKGROUND/AIMS Among the diseases related to oral health, such as caries and oral cancer, dental trauma stands out as one of the major public health problems worldwide. The aim of this study was to verify the occurrence of factors associated with traumatic dental injuries (TDIs), including oral health-related quality of life (OHRQoL), sociodemographic characteristics, untreated caries, occlusal problems and contextual variables in 12-year-old Brazilian children. METHODS This study assessed a complex sample of the National Research in Oral Health (SBBrasil 2010) data on 7240 12-year-old children and contextual features of the municipalities where they lived. RESULTS TDI prevalence in 12-year-old schoolchildren was 23.96%. Being female was a protective factor for all trauma outcome variables. Non-white children were at risk of maxillary tooth fractures. Maxillary overjet greater than 3 mm was associated with all trauma outcomes. Crowding and spacing were risk factors for enamel trauma. TDI has a negative impact on OHRQoL. None of the contextual variables analysed (Gini coefficient, MHDI, family health strategy and water fluoridation) were associated with TDI in the multilevel approach. CONCLUSIONS TDI was better explained by individual factors, related to sociodemographic conditions and occlusal problems, with a negative impact on OHRQoL, adjusted for untreated caries. Contextual variables were not associated with TDI in 12-year-old Brazilian schoolchildren. Interdisciplinary actions for preventing dental trauma, such as stimulating the use of mouthguards, have to be encouraged by the family health strategy (FHS) and school health programme (SHP).
Do crescimento das taxas de depressão e de suas causas

O presente artigo se propoe a colocar em relevo e discutir algumas perspectivas definidas em artigo recente sobre a etiologia e atual prevalencia da depressao. Neste artigo, de 2008, Moreira desenvolve um engenhoso argumento (inspirado na "cultura do narcisismo") para explicar o 'aumento da depressao na sociedade atual', em face do que destaco: 1) Os estudos epidemiologicos que um dia deram substrato a este tipo de assuncao sao os mesmos que apontaram crescimento de alcoolismo, transtorno bipolar, sindrome do pânico e outros, de modo que uma explicacao baseada "na cultura do narcisismo" precisaria explicitar porque e como esta cultura gera o crescimento das outras desordens, ou entao diferenciar os eixos do crescimento da depressao; 2) Estudos epidemiologicos gigantescos e estatisticamente controlados mostram que as taxas de depressao vem se mantendo constantes 'na sociedade atual'. Por fim, uma explicacao alternativa para esta impressao de crescimento e oferecida