Miracle-dz/UniFAR-FTUs huggingface dataset:
Purification and properties of the glutathione reductase of Chromatium vinosum

The Chromatium vinosum glutathione reductase [NAD(P)H: glutathione disulfide oxidoreductase, EC 1.6. 4.2] was purified to apparent homogeneity. The enzyme was found to require reduced nicotinamide adenine dinucleotide (NADH) as a reductant and to be specific for oxidized glutathione (GSSG). The polypeptide molecular weight in sodium dodecyl sulfate was found to be 52,000. Incubation of enzyme with NADH in the absence of GSSG resulted in a significant loss in activity. The enzyme was stimulated by phosphate and sulfate ion, but was inhibited by chloride ion, heavy metals, and sulfhydryl reagents. Adenylate nucleotides were inhibitory, and the data suggested that they were acting as competitive inhibitors of flavin adenine dinucleotide (FAD). The Km values of 7 X 10-3 for GSSG and 6 X 10-5 M for NADH were the highest reported of any previously investigated glutathione reductase. The order of addition of components markedly affected the response of the enzyme to FAD. A requirement for FAD (Km 5.2 X 10-7 M) was seen if the enzyme was incubated with NADH prior to GSSG addition, whereas no FAD was required if the order was reversed.
Media Strategy vs. Content Strategy in Online Advertising: Exploring the Influence of Consumers' Goal-Directedness for Web Navigation

As the Internet grows rapidly, how online media can be best utilized for advertising purposes increases its importance. Based on the Elaboration Likelihood Model (ELM), this research incorporates consumers’ goal-directedness for Web navigation as an important moderator influencing the success of online advertising strategies. Using the lab experiment approach, results of this research not only support the perspective of the ELM but also show how both advertising strategies (media/content) should be designed and implemented in accordance with consumers’ goal-directedness for Web navigation to achieve maximum advertising effectiveness. Results of this research demonstrate the uniqueness of the online media and also remind future researchers of the importance of goal-directness for Web navigation and consumer involvement in the online advertising context.
Improving Context-Based Load Value Prediction

Microprocessors are becoming faster at such a rapid pace that other components like random access memory cannot keep up. As a result, the latency of load instructions grows constantly and already often impedes processor performance. Fortunately, load instructions frequently fetch predictable sequences of values. Load value predictors exploit this behavior to predict the results of load instructions. Because the predicted values are available before the memory can deliver the true load values, the CPU is able to speculatively continue processing without having to wait for memory accesses to complete, which improves the execution speed. The contributions of this dissertation to the area of load value prediction include a novel technique to decrease the number of mispredictions, a predictor design that increases the hardware utilization and thus the number of correctly predicted load values, a detailed analysis of hybrid predictor combinations to determine components that complement each other well, and several approaches to substantially reduce the size of hybrid load value predictors without affecting their performance. One result of this research is a very small yet high-performing load value predictor. Cycle-accurate simulations of a four-way superscalar microprocessor running SPECint95 show that this predictor outperforms other predictors from the literature by twenty or more percent over a wide range of sizes. With about fifteen kilobytes of state, the smallest examined configuration, it surpasses the speedups delivered by other, five-times larger predictors both with a re-fetch and a re-execute misprediction recovery mechanism.
Continuous Departure Time Choice Model: A Case Study in Tokyo

This paper formulates a departure time choice based on a time allocation model and analyzes it with the empirical data. Stated choice data of urban rail commuters are used for empirical analysis. The model assumes the continuous time choice in which an individual maximizes his/her utility under the constraints of time and monetary budgets. As our model explicitly incorporates the utilities stemming from sleeping hours and in-home or out-of-home leisure, the individual’s preference of these activities can be analyzed directly. For example, the results of empirical analysis show that the married individuals obtain higher marginal utility from sleeping time. The results of empirical analysis also show that the fare level at the arrival time or at the time of starting work influence the individual’s marginal utility with respect to the schedule delay of arrival, starting work, and sleeping.
Medical school radiology lectures: what are determinants of lecture satisfaction?

OBJECTIVE Slideshow presentations are a popular teaching method in undergraduate medical education; however, there are scant data on determinants of lecture satisfaction. The purpose of this study is to determine which features of undergraduate medical school radiology lectures are associated with better student evaluations. MATERIALS AND METHODS All undergraduate medical school radiology presentations and student evaluations at the University of Ottawa from January to December 2013 were compiled. A standardized data extraction sheet was applied by two independent reviewers, including a 10% overlap for audit. Student evaluations were reported on a 5-point Likert scale from which an overall mean score per lecture was calculated. Correlation coefficients were calculated for continuous variables in relation to mean evaluation score. Student t tests and univariate ANOVAs were performed for categoric data. Quantitative content analysis of student comments was also undertaken. RESULTS Sixty-four slideshows by 33 lecturers were analyzed. The overall mean (SD) evaluation score was 4.38 ± 0.30. The strongest positive correlation with mean evaluation score was for type size (r = 0.32; p = 0.01), whereas the strongest negative association was for number of clinical cases presented (r = -0.32; p = 0.01). No association with percentage of text slides (r = 0.19; p = 0.14) or mean number of images on an image slide (r = -0.22; p = 0.08) was identified. Content analysis revealed a moderate positive correlation between percentage of total slides containing text only and the percentage of positive comments (r = 0.31) and a weak correlation between the mean number of images per image slide and the percentage of negative comments (r = 0.24). CONCLUSION Larger type size and a higher proportion of text slides were more favored by medical students.
Comparison of lung deposition in two types of nebulization: intrapulmonary percussive ventilation vs jet nebulization.

BACKGROUND So-called intrapulmonary percussive ventilation (IPV), frequently coupled with a nebulizer, is increasingly used as a physiotherapy technique; however, its physiologic and clinical values have not been rigorously assessed. STUDY OBJECTIVE To compare in vitro and in vivo characteristics of the nebulizer of the IPV device (Percussionaire; Percussionaire Corporation; Sandpoint, ID) with those of standard jet nebulization (SST) [SideStream; Medic-Aid; West Sussex, UK]. DESIGN Aerodynamic particle size was studied by an cascade impactor. The deposition of (99m)Tc-diethylenetriaminepenta-acetic acid was measured in 10 healthy subjects by tomoscintigraphy during spontaneous breathing with both nebulizers. MEASUREMENTS AND RESULTS The mass median aerodynamic diameter (0.2 micro m vs 1.89 micro m for IPV and SST, respectively) and the fine-particle fraction (16.2% vs 67.5%, respectively) were significantly smaller with IPV. In vivo, respiratory frequency (RF) was lower with the IPV device (10.1 +/- 3.4 breaths/min vs 14.6 +/- 3.4 breaths/min, p = 0.002). Whole-body deposition was significantly higher with IPV (15.63% vs 9.31%), but it was due to a higher extrapulmonary deposition. Although intrapulmonary deposition (IPD) was not different with both devices (4.20% for SST vs 2.49% for IPV), it was much more variable with IPV, compared to SST. The penetration index into the lung was higher with IPV than SST when normalized for RF (0.045 +/- 0.018 breaths/min vs 0.026 +/- 0.013 breaths/min, p = 0.007). CONCLUSION The two techniques showed comparable lung deposition despite a large difference in particle size. However, IPV IPD was too variable and thus too unpredictable to recommend its use for drug delivery to the lung.
Effective Recruitment: A Framework

The changing business scenario and vigorous talent hunt underline the need for new recruitment strategies. In this context, the importance of HR in any organization has grown severalfold. Its strong impact on Return on Investment (ROI) and company’s success in the marketplace have placed significant emphasis on effective recruitment strategies from an individual, organizational and societal perspectives that lead to increased ROI and economic viability of the organization. In a nutshell, effective recruitment strategies result in developing and engaging a committed workforce whose talent and supremacy lead to the creation of competitive advantages and unmatchable business success in the marketplace.
Glassy cell carcinoma of the cervix--a case report with review of the literature.

BACKGROUND Glassy cell carcinoma of the uterine cervix is a rare neoplasm, first described by Gluksman and Cherry in 1956. It is a poorly differentiated adenosquamous carcinoma, comprising about 1-2% of all cervical cancers. CASE PRESENTATION We report a case of glassy cell carcinoma of the uterine cervix in 67-year-old female, nullipara, diagnosed two months after symptom onset, in IV-B stage of the disease according to the FIGO classification scale. Cervical smear test obtained three years previously was normal She was offered a palliative antihemorrhagic radiotherapy of the pelvis and palliative chemotherapy with paclitaxel-carboplatin combination. The patient died within six months of diagnosis. CONCLUSIONS We present a case of a rare carcinoma of the uterine cervix with quick progression and poor outcome.
Attracting Microfinance Investment Funds: Promoting Microfinance Growth through Increased Investments in Kenya

Although microfinance has played a significant role in providing a wide range of financial products and services, many microfinance institutions (MFIs) in Kenya still face major challenges with efficiently and effectively delivering microfinance services in the country. As the demand for these services continues to grow, the limited sources of available capital have greatly undermined the capabilities of MFIs to efficiently operate their services and expand their various microfinance activities. This has led to a financial gap in the supply of microfinance services, and consequently has reduced the opportunities for the poor to access basic socio-economic benefits that could potentially improve their wellbeing. The widening financial gap in the microfinance sector has been attributed to self-governance issues, capacity building issues, non-compliance with reporting requirements, and a lack of appropriate performance criteria. These and other factors have jeopardized MFIs sustainability and have compromised the delivery of microfinance services in the country. There is a need for a policy that advocates for better access to capital sources and investment opportunities for microfinance sustainability, and also encourages MFIs to increase their accessibility, build capacity, be more transparent, adopt acceptable performance standards, and promote professionalism to enhance service delivery. This paper analyzes three policy alternatives which include: (i) maintaining the status quo; (ii) government regulation of all MFIs; and (iii) voluntarily self-regulating by member MFIs as alternatives for closing the financial gap in the supply of microfinance services. All the three alternatives are evaluated against the following criteria: efficiency, financial and political feasibility, and accessibility to determine the best policy option.
DNA-dependent divalent cation binding in the nucleosome core particle

Sequence-specific binding of divalent cations to nucleosomal DNA can potentially influence nucleosome position and mobility, as well as modulate interactions with nuclear factors. We define the bonding and specificity of divalent cation interaction with nucleosomal DNA by characterizing Mn2+ binding in the x-ray structure of the nucleosome core particle at 1.9-Å resolution. Manganese ions are found ligated with high occupancy in the major groove to 12 of 22 GG and GC base pair steps. The specific location and mode of metal binding is the consequence of unambiguous conformational differences between dinucleotide sites, owing to their sequence context and orientation in the nucleosome core.
Macroprudential Supervision: A Key Lesson from the Financial Crisis

Banking crises such as the latest financial crisis of 2008–09 have a major impact on the real economy, reveal fragilities in financial markets and shed light on (often severe) gaps in banking regulation and supervision. Obviously, during the current crisis, banks had inadequate capital and liquidity buffers to absorb shocks. At the moment, a reform of microprudential regulation is well under way within the framework first established more than 25 years ago by the Basel Capital Accord. However, recent literature on the economics of banking regulation highlights that a more innovative approach is required to deal with the three main crisis catalysts as revealed by the current financial crisis: • The financial system has become substantially more interconnected and complex over the last twenty years. In addition, more complex contagion channels have emerged (e.g. derivative exposures), and shocks can now spread throughout the global financial system almost immediately. • The adverse impact of the financial system’s inherent cyclicality on financial stability was severely underestimated. • Many banks today are too big to fail. They cannot exit the market without causing substantial negative externalities for other financial institutions and the real economy. As a consequence, they are bailed out by the public sector if necessary. This implicit government guarantee leads to severe incentive problems, which in turn result in an inefficient allocation of capital and risk within the economy. At the European level, these issues are addressed i.a. by the Bank Recovery and Resolution Directive (BRRD), the Single Resolution Mechanism (SRM), the Macroprudential supervision: A Key lesson from the Financial crisis
Developments in the treatment of visceral leishmaniasis

Background: Visceral leishmaniasis (VL) is one of the most neglected parasitic diseases causing large scale mortality and morbidity among the poorest of the poor in the Indian subcontinent and Africa. Objective: This review aims to describe the potential and the (lack of) current impact of newly developed treatments on the control of VL. It describes how the problem of an empty research pipeline is addressed, and discusses the emerging threat of incurable HIV/VL coinfection. Methods: The literature was searched for drugs used in VL. Conclusion: Research and development of VL drugs has received a financial boost but no new drugs are expected in the next 5 years. Only three new and highly effective treatments have been licensed in the past 10 years. These remain, however, largely inaccessible as VL control programs in the developing world are lacking. This is deserving of immediate and urgent attention, especially in the context of the rapidly expanding HIV/VL coinfection.
Effects of Acute Sleep Restriction on Behavior, Sustained Attention, and Response Inhibition in Children

This study examined the effects of acute sleep restriction on the daytime behavior and performance of healthy children and adolescents. 82 participants (8 to 15 years of age) completed 5 nights of baseline sleep and were randomly assigned to Optimized (10 hr.) or Restricted (4 hr.) sleep for an overnight lab visit. Behavior, performance, and sleepiness were assessed the following day. Sleep restriction was associated with shorter daytime sleep latency, increased subjective sleepiness, and increased sleepy and inattentive behaviors but was not associated with increased hyperactive-impulsive behavior or impaired performance on tests of response inhibition and sustained attention. Results are discussed in terms of current theories regarding effects of inadequate or disturbed sleep among children and adolescents.
User Datagram Protocol

UDP does not guarantee reliability or ordering in the way that TCP does. Datagrams may arrive out of order, appear duplicated, or go missing without notice. Avoiding the overhead of checking whether every packet actually arrived makes UDP faster and more efficient, at least for applications that do not need guaranteed delivery. Time-sensitive applications often use UDP because dropped packets are preferable to delayed packets. UDP's stateless nature is also useful for servers that answer small queries from huge numbers of clients. Unlike TCP, UDP supports packet broadcast (sending to all on local network) and multicasting (send to all subscribers).
Interaction between internal audit and different organisational parties: An analysis of expectations and perceptions

This study, based on six case studies within a Belgian context, provides a qualitative assessment of the interaction between internal auditors and the audit committee as well as CEOs and CFOs by analysing their expectations and perceptions. It became clear that both groups have high expectations vis-a-vis the internal auditor(s), although the perceptions of the interactions are not universally positive. On the one hand, audit committee members want the internal auditor(s) to be(come) an important information provider. Therefore they expect the internal auditor(s) to demonstrate and communicate as much as possible their contribution to the monitoring and functioning of the organisation as well as to play a (pro)active role in risk management. It became clear that in most cases, due to a mismatch of interests, there is an under-emphasis on the internal audit oversight roles of the audit committee, which is more perceived by the internal auditors than by audit committee members. In order to reduce this mismatch, both parties should broaden their interests in a converging way completed with a clear communication about the mission and roles of internal audit. On the other hand, CEOs and CFOs want the internal auditor(s) to compensate their loss of control that results from an increased organisational complexity. CEOs and CFOs expect the internal auditor(s) to fulfil an active management supporting role with a strong focus on continuous improvement in risk management, internal controls, organisational processes and strategic important projects. Thereby, internal auditor(s) are expected to create a sufficient level of risk and control awareness within the organisation. Although the interaction with CEOs and CFOs is stronger than the interaction with audit committee members, we found that the expression of findings and suggestions in more quantitative terms and regular informal contacts can still improve this interaction.
Time-Driven Activity-Based Costing: A Simpler and More Powerful Path to Higher Profits

In the classroom, ABC looks like a great way to manage a company's resources. But many executives who have tried to implement ABC on a large scale in their organizations have found the approach limiting and frustrating. Why? The employee surveys that companies used to estimate resources required for business activities proved too time-consuming, expensive, and irritating to employees. This book shows you how to implement time-driven activity-based costing (TDABC), an easier and more powerful way to implement ABC. You can now estimate directly the resource demands imposed by each business transaction, product, or customer. The payoff? You spend less time and money obtaining and maintaining TDABC data--and more time addressing problems that TDABC reveals, such as inefficient processes, unprofitable products and customers, and excess capacity. The authors also show how to use TDABC to link strategic planning to operational budgeting, to enhance the due diligence process for mergers and acquisitions, and to support continuous improvement activities such as lean management and benchmarking. In presenting their model, the authors define the two questions required to build TDABC: 1) How much does it cost per time unit to supply resource capacity for each business process? 2) How much resource capacity (time) is required to perform work for a company's many transactions, products, and customers? The book demonstrates how to develop simple, valid answers to these two questions. Kaplan and Anderson illustrate the TDABC approach with a wealth of case studies, in diverse settings, based on actual implementations.
Changes in Leadership Style, Management Control and Management Accounting

This paper investigates how management accounting change, the leadership style of managers and the (satisfaction of) needs of employees are related. The paper is based on a case study in a multi-outlet car dealership. Accounting change concerns both an organizations' accounting rules and its routines (Burns and Scapens 2000). The way in which managers use accounting information is related to their leadership styles (Hopwood 1974). As a consequence, new accounting rules imposed on the organization by its top management can be classified in two categories: rules that fit with the leadership styles of the managers and rules that do not fit with these leadership styles. The case study in the paper demonstrates how new accounting rules can result in new accounting routines, both in a situation in which the new rules and the leadership styles of managers do fit and in a situation in which they do not fit. Leadership styles differ in how they appeal to the needs of employees: transactional leaders emphasize their employees' physical needs, whereas transformational leaders emphasize their socio-emotional needs. If, in relation to accounting change, the leadership styles of managers also change, this may affect the satisfaction of the needs of a company's employees. The case study demonstrates how accounting change and the satisfaction of the needs of employees are related. The effects of accounting change on the satisfaction of the needs of employees results in support or resistance against the change.
Foreign Exchange Option Pricing: A Practitioner's Guide

Excellent book is always being the best friend for spending little time in your office, night time, bus, and everywhere. It will be a good way to just look, open, and read the book while in that time. As known, experience and skill don't always come with the much money to acquire them. Reading this book with the PDF foreign exchange option pricing a practitioners guide will let you know more things.