Miracle-dz/UniFAR-FTUs huggingface dataset:
Severe hypernatremia and transient azotemia in a cat following inadvertent intravenous administration of a commercial polyethylene glycol solution.

OBJECTIVE To describe the clinical signs, clinicopathologic abnormalities, treatment, and outcome after IV administration of polyethylene glycol 3350 (PEG3350) in a cat. CASE SUMMARY A cat was inadvertently administered 6 g/kg of PEG3350 in electrolyte solution, IV, resulting in severe hypernatremia (203 mmol/L), diffuse encephalopathy, hemolysis, and moderate azotemia. The hemolysis and acute kidney injury observed immediately following PEG3350 administration resolved with supportive care. Administration of IV and oral electrolyte-free water slowly corrected the hypernatremia and the neurologic signs subsequently improved. Complete resolution of clinical signs was documented one month following hospital discharge. The PEG3350 concentrations in serum, plasma, and urine samples confirmed toxic exposure to PEG3350. Efficacy of treatment was evident by decreasing concentrations of PEG3350 in serum after the first 24 hours of treatment. Renal elimination of PEG3350 was significant and PEG3350 was still detected in the urine 17 days after exposure. NEW INFORMATION PROVIDED This is the first report to describe the clinical signs and clinicopathologic abnormalities in a cat intoxicated with IV PEG3350. Potential pathophysiologic mechanisms are discussed, and the successful supportive medical treatment is outlined.
Alpha-1-Antitrypsin Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice

Diffuse alveolar hemorrhage (DAH) is a fatal complication in patients with lupus. DAH can be induced in B6 mice by an intraperitoneal injection of pristane. Since human alpha-1-antitrypsin (hAAT) is an anti-inflammatory and immuno-regulatory protein, we investigated the protective effect of hAAT against pristane-induced DAH in B6 mice and hAAT transgenic (hAAT-Tg) mice. We first showed that hAAT Tg expression lowers TNF-α production in B cells, as well as CD4+ T cells in untreated mice. Conversely, the frequency of regulatory CD4+CD25+ and CD4+CD25-IL-10+ cells was significantly higher in hAAT-Tg than in B6 mice. This confirmed the anti-inflammatory effect of hAAT that was observed even at steady state. One week after a pristane injection, the frequency of peritoneal Ly6Chi inflammatory monocytes and neutrophils in hAAT-Tg mice was significantly lower than that in B6 mice. Importantly, pristane-induced DAH was completely prevented in hAAT-Tg mice and this was associated with a modulation of anti- to pro-inflammatory myeloid cell ratio/balance. We also showed that treatment with hAAT decreased the severity of DAH in B6 mice. These results showed for the first time that hAAT has a therapeutic potential for the treatment of DAH.
Colour associations in a young adult Indian population

Colour possesses a powerful symbolic function that might predate the emergence of language and its use as a sign is prevalent in almost any human activities. The nature and the underlying structure of word-colour associations are of interest for colour theory, semiotic and aesthetics. In this study, data reduction and visualisation analyses i.e., exploratory factor analysis and Multidimentional scaling were performed with the aim to identify word-colour association patterns. In a free association task, thirty-seven Indian young adults spontaneously associated words to eight colours (spaning over the colour circle) providing a total of 1333 associations. Three different structures were identified. A first structure extracted from Natural Object word-colour associations revealed three components: [Bluish – Water], [Greenish – Vegetation] and [Yellowish/Red Fruits] is evocative of archetypical associations. The second structure derived from Concept word-colour associations correspond to [Cool Positive Emotion Low Energy] vs. [Warm Religion and Spirituality] colours with an additional third [Blue/Purple – Lifestyle] component and reflects socio-cultural stereotypes. The third structure extracted for Man-Made Objects wordcolour associations is undefined in terms of colour order system, the association seem to be idiosyncratic to the sample of participants tested.
A chirality‐dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics

Kirsten rat sarcoma (KRAS) mutant cancers, which constitute the vast majority of pancreatic tumors, are characterized by their resistance to established therapies and high mortality rates. Here, we developed a novel and extremely effective combinational therapeutic approach to target KRAS mutant tumors through the generation of a cytotoxic oxidative stress. At high concentrations, vitamin C (VC) is known to provoke oxidative stress and selectively kill KRAS mutant cancer cells, although its effects are limited when it is given as monotherapy. We found that the combination of VC and the oxidizing drug arsenic trioxide (ATO) is an effective therapeutic treatment modality. Remarkably, its efficiency is dependent on chirality of VC as its enantiomer d‐optical isomer of VC (d‐VC) is significantly more potent than the natural l‐optical isomer of VC. Thus, our results demonstrate that the oxidizing combination of ATO and d‐VC is a promising approach for the treatment of KRAS mutant human cancers.
What is of interest in Endodontology? A bibliometric review of research published in the International Endodontic Journal and the Journal of Endodontics from 1980 to 2019.

AIM To report the most common terminology used in titles of scientific papers published in the International Endodontic Journal (IEJ) and Journal of Endodontics (JOE) between 1980-2019 and to identify the most cited papers in these journals. METHODOLOGY The Web of Science database was searched to retrieve all the manuscripts published in the IEJ and JOE between 1980 and 2019. The articles were analyzed using the VOS viewer software and the terms within the titles extracted. The top-10 terms were categorized according to the number of occurrences and the decade of publication. Maps were created using the text data for each decade of publication. Classic papers were identified when the number of citations was >400. During the same period of time, highly cited studies were identified including the authors, institutions and countries associated with these papers. RESULTS Terms such as canal, molar and periapical lesion were the most commonly used in titles between 1980 and 1999. The terms instruments, expression, case report and cell were the most often terms used between 2000 and 2019. During the last 10 years an increase in the number of reviews and papers on Cone Beam Computed Tomography occurred. The organizations with the largest number of citations in each decade were University of São Paulo, University College London, Loma Linda University and United States Army. The country with the largest number of citations and greatest number of top 10 and top 100 manuscripts was the USA. A paper had to be associated with more than 167 citations to be included in the top-100 most cited list; at least 14 papers met the criteria to be categorized as a citation classic (>400 citations). CONCLUSION While many diverse areas of Endodontics have been explored in the last 40 years only a relatively few topics are highly-cited and can be considered as classics. This article is protected by copyright. All rights reserved.
Aircraft Authentication for Image Processing

Aircraft recognition remains a challenging problem despite a great deal of effort to automate the recognition process. Most of the aircraft recognition methods involve extraction of overall shapes of aircraft at first and then represent the aircraft based on the extracted shape with different features for recognition. The major disadvantage of these methods is that they require a huge amount of analysis on shape extraction, which is too unrealistic for targets in satellite images. we propose a new hybrid recognition method that combines contour wavelet features and correlation on shape analysis. Initially, direction estimation is used to align the aircraft in same direction. Then, reconstruction based similarity measure is introduced to transform the type recognition problem into a reconstruction problem. Filtration is done for Gaussian noise removal purpose and wavelet transform is used as a feature extraction method. Fuzzy clustering is done in final to carry out segmentation on aircraft image. The performance of these used algorithms will be differentiated though precision and recall rate metrics. The experimental results illuminate the accuracy and efficiency of the proposed system to recognize aircraft in satellite remote sensing images.
A global invasion by the thrip, Frankliniella occidentalis: Current virus vector status and its management

Western flower thrip, Frankliniella occidentalis (Pergande), is among the most economically important agricultural pests globally, attacking a wide range of vegetable and horticultural crops. In addition to causing extensive crop damage, the species is notorious for vectoring destructive plant viruses, mainly belonging to the genera Orthotospovirus, Ilarvirus, Alphacarmovirus and Machlomovirus. Once infected by orthotospoviruses, thrips can remain virulent throughout their lifespan and continue transmitting viruses to host plants when and wherever they feed. These irruptive viral outbreaks in crops will permanently disrupt functional integrated pest management systems, and typically require a remedial treatment involving insecticides, contributing to further development of insecticide resistance. To mitigate against this continuing cycle, the most effective management is early and comprehensive surveillance of the pest species and recognition of plant viruses in the field. This review provides information on the pest status of F. occidentalis, discusses the current global status of the viruses vectored by this thrip species, examines the mechanisms involved in transmitting virus‐induced diseases by thrips, and reviews different management strategies, highlighting the potential management tactics developed for various cropping systems. The early surveillance and the utilization of potential methods for control of both F. occidentalis and viruses are proposed.
The α-η-κ-μ Fading Model: An Exact Statistical Representation

The $\alpha$-$\eta$-$\kappa$-$\mu$ is one of the most generalized and flexible channel models having an excellent fit to experimental data from diverse propagation environments. The existing statistical results on the envelope of $\alpha$-$\eta$-$\kappa$-$\mu$ model contain an infinite series involving regularized hypergeometric function and generalized Laguerre polynomial, prohibiting its widespread application in the performance analysis of wireless systems. In this paper, we employ a novel approach to derive density and distribution functions of the envelope of the $\alpha$-$\eta$-$\kappa$-$\mu$ fading channel without an infinite series approximation. The derived statistical results are presented using a single Fox's H-function for tractable performance analysis and efficient numerical computations, especially for high-frequency mmWave and terahertz wireless transmissions. To gain insight into the distribution of channel envelope, we develop an asymptotic analysis using a more straightforward Gamma function converging to the exact within a reasonable range of channel parameters. To further substantiate the proposed analysis, we present the exact outage probability and average bit-error-rate (BER) performance of a wireless link subjected to the $\alpha$-$\eta$-$\kappa$-$\mu$ fading model using a single tri-variate Fox's H-function. We obtain the diversity order of the system by analyzing the outage probability at a high signal-to-noise (SNR) ratio. We use numerical and simulation analysis to demonstrate the significance of the developed statistical results compared with the existing infinite series representation for the envelope of the $\alpha$-$\eta$-$\kappa$-$\mu$ model.
Large‐scale distribution of bacterial communities in the Qaidam Basin of the Qinghai–Tibet Plateau

Many studies have investigated patterns of soil microbial communities over large spatial scales. However, these studies mainly focused on a few sites. Here, we studied the near‐surface (0–30 cm) soil microbial communities of 35 soil samples collected from most of the areas of the Qaidam Basin, which is the largest basin on the Qinghai–Tibet Plateau. A total of 32 phyla and 838 genera were detected from all the samples, in which Actinobacteria, Proteobacteria, Bacteroidetes, and Acidobacteria were the most dominant and cosmopolitan phyla. The most abundant phyla (relative abundance > 5%) detected in all 35 soil samples were also the most dominant, which could be explained by their great dispersal ability. The microbial community structures correlated strongly with variations in pH and Mg2+ and were distinct between the high Mg2+ content (>20 g/kg) samples and other samples (Acidobacteria, Actinobacteria, and Chloroflexi were significantly less abundant in the high Mg2+ content group, but the abundance of Firmicutes was significantly greater). Finally, the microbial spatial pattern was influenced by both the local environment and spatial distance, but environmental factors were the primary drivers of microbial spatial patterns in the Qaidam Basin.
Nonlinear gene expression‐phenotype relationships contribute to variation and clefting in the A/WySn mouse

Cleft lip and palate is one of the most common human birth defects, but the underlying etiology is poorly understood. The A/WySn mouse is a spontaneously occurring model of multigenic clefting in which 20% to 30% of individuals develop an orofacial cleft. Recent work has shown altered methylation at a specific retrotransposon insertion downstream of the Wnt9b locus in clefting animals, which results in decreased Wnt9b expression.
Micropositioning of 2 DOF Piezocantilever : LKF Compensation of Parasitic Disturbances

This paper presents a new control method devoted to improve the performances of 2-DOF piezoelectric actuator for precise positioning tasks. The piezoelectric actuator exhibits strong cross-couplings between its two axes and strong hysteresis and creep nonlinearities. These unwanted phenomena undeniably compromised therefore the final precision of the targeted tasks (micromanipulation) and should be conveniently accounted during the controller synthesis. In this paper, we proposed a combination of the discrete linear Kalman filtering with a closed-loop scheme to suppress the effects of the couplings and of the nonlinearities. The suggested method permits to improve the performances of the piezoelectric actuator without specific and detailed characterization and knowledges on the hysteresis and on the creep models. Extensive experiments were carried out with complex desired trajectories and demonstrate the efficiency of the novel approach.
THE PERIPHERAL REDUCTION IN BURN PROBABILITY AROUND RECENT BURNS IN THE BOREAL FOREST

2.1 The model Despite increasing knowledge of the factors responsible for landscape flammability, predicting its magnitude and spatial distribution over a large area has been largely unattained. This exercise is even more challenging in highly variable fire regimes such as the boreal forest of Canada, where most of the area burned is caused by few large fires that occur only periodically. In fact, in this biome, 2-3% of the fires are responsible for 97% of the area burned (Weber and Stocks 1998). The BURN-P3 model (Kafka et al., in prep.) integrates the physical components of fire spread to the probabilistic aspects of the fire regime. While fire spread is simulated through physical fire growth modeling (WILDFIRE, Todd 1999) based on the Canadian Forest Fire Danger Rating System (Van Wagner 1987, Forestry Canada 1992), the probabilistic aspects of BURN-P3 are based on historical data, and include: In order to better predict the likelihood of burning on the boreal landscape, one must understand the factors that drive the spread of large fires and, perhaps more importantly, the variability in time and space associated with this phenomenon (Lertzman et al. 1998). Furthermore, as the forest undergoes succession and land-use changes, the flammability of the forest changes accordingly. This change is reflected both locally by the structure and composition of forest fuels and on a larger spatial scale through changes in relative abundance and connectivity (Finney 2001). (i) the location and frequency of ignitions, (ii) the rate at which fires escape initial attack and become large, (iii) the number of days each fire experiences significant spread, (iv) the weather conditions associated with this spread.
circPIP5K1A serves as a competitive endogenous RNA contributing to ovarian cancer progression via regulation of miR‐661/IGFBP5 signaling

Increasing evidence demonstrates the crucial regulatory functions of circular RNAs in different cancer types. The major aim of the current study was to establish functions of circPIP5K1A during ovarian cancer. Our results showed an increased expression of circPIP5K1A in both ovarian cancers and cell lines, which was associated with poor prognosis. In functional analyses, downregulation of circPIP5K1A suppressed ovarian cancer cell migration, proliferation, and invasion in vitro. The miR‐661 was indicated as a target of circPIP5K1A and insulin‐like growth factor‐binding protein 5 (IGFBP5) as a target of miR‐661. circPIP5K1A silencing triggered downregulation of IGFBP5 through inducing an increase in miR‐66 levels, as determined by the luciferase reporter assay. Data from cell counting kit‐8, colony formation, wound healing, and Transwell assays showed that overexpression of IGFBP5 effectively reversed the circPIP5K1A depletion effects. The results collectively indicated that circPIP5K1A contributed to ovarian cancer progression via targeting the miR‐661/IGFBP5 axis, supporting its utility as a candidate target for therapy of the disease.
Feasibility study of an intervention to improve emotional well‐being and cognitive functioning in brain tumour survivors

High‐grade brain tumour patients (WHO grades III and IV) routinely demonstrate high levels of psychological distress and a diverse range of cognitive impairments, with common deficits in areas of memory, attention, and executive functioning. Given the overlapping impact of both cognitive and psycho‐emotional challenges, there would be strong value in developing a psychologically based intervention capable of addressing both emotional and cognitive challenges in this population. However, a review of the literature identified only three published, small n studies that have adopted this dual aim. This previous work suggests that this kind of approach has potential value but also that recruitment can be particularly challenging in this population. In this light, this pilot study aimed to develop and evaluate the feasibility of an innovative program to treat individuals with high‐grade brain tumours via videoconferencing into participants' homes to enhance accessibility. We also piloted neurocognitive and psychological testing at all evaluation points. More specifically, we set out to assess the feasibility of recruitment, retention, and videoconference delivery, satisfactoriness, and areas of potential improvements.
Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

Uncoupling of mitochondrial respiration by chemical uncouplers has proven effective in ameliorating obesity, insulin resistance, and hyperglycemia. However, development of uncoupler-based therapy remains challenging due to its potentially lethal adverse effects. Here, we identify pyruvate dehydrogenase (PDH) as a key modifier of the toxicity profile of 2, 4-dinitrophenol (DNP), a prototypical mitochondrial uncoupler. PDH activation by dichloroacetic acid (DCA) protects mice from DNP-induced hyperlactacidemia, hyperthermia, and death while preserving the ability of DNP to promote fuel oxidation and improve insulin sensitivity in mice. Mechanistically, PDH activation switches on mitochondrial glucose oxidation to accommodate increased glycolytic flux, leading to reduced lactate secretion during uncoupler treatments. We devised a chemical screening strategy and discovered compound 6j as a dual-action compound that simultaneously activates PDH and uncouples mitochondrial respiration. Compound 6j exhibits an excellent efficacy and safety profile in restoring glucose homeostasis in diabetic mice. This work establishes a new principle to safely harness the power of chemical uncouplers for the treatment of metabolic disease.
Numerical assessment of PML transmission conditions in a domain decomposition method for the Helmholtz equation

The convergence rate of domain decomposition methods (DDMs) strongly depends on the transmission condition at the interfaces between subdomains. Thus, an important aspect in improving the efficiency of such solvers is careful design of appropriate transmission conditions. In this work, we will develop an efficient solver for Helmholtz equations based on perfectly matched layers (PMLs) as transmission conditions at the interfaces within an optimised restricted additive Schwarz (ORAS) domain decomposition preconditioner, in both two and three dimensional domains. We perform a series of numerical simulations on a model problem and will assess the convergence rate and accuracy of our solutions compared to the situation where impedance boundary conditions are used.
Nanostructured based Electrochemical Sensor for Voltammetric Determination of Ascorbic Acid in Pharmaceutical and Biological Samples

A novel carbon paste electrode modified with carbon nanotubes and 5-amino-2',4'dimethoxy-biphenyl-2-ol (5ADMB) was fabricated. The electrochemical study of the modified electrode, as well as its efficiency for electrocatalytic oxidation of ascorbic acid, is described. Cyclic voltammetry was used to investigate the redox properties of this modified electrode at various scan rates. The apparent charge transfer rate constant, ks, and transfer coefficient, α, for electron transfer between 5ADMB and carbon nanotubes paste electrode were calculated as 7.94 s −1 and 0.5, respectively. The electrode was also employed to study the electrocatalytic oxidation of ascorbic acid, using cyclic voltammetry, chronoamperometry Analytical & Bioanalytical Electrochemistry © 2014 by CEE www.abechem. com Anal. Bioanal. Electrochem. , Vol. 6, No. 1, 2014, 54 66 55 and square wave voltammetry as diagnostic techniques. It has been found that the oxidation of ascorbic acid at the surface of modified electrode occurs at a potential of about 250 mV less positive than that of an unmodified CPE. The diffusion coefficient, electron transfer coefficient, and heterogeneous rate constant, for oxidation of ascorbic acid at the modified electrode surface were also determined. Square wave voltammetry (SWV) exhibits a linear dynamic range from 1.0×10 -6 to 7.5×10 −4 M and a detection limit of 0.1 μM for ascorbic acid. Finally this modified electrode was used for determination of ascorbic acid in real samples. KeywordsAscorbic acid, Carbon nanotube paste electrode, Modified electrode, voltammetry