Miracle-dz/UniFAR-FTUs huggingface dataset:
Involvement of Gypsum (CaSO4 · 2H2O) in Water Treatment Sludge Dewatering: A Potential Benefit in Disposal and Reuse

Abstract This research assessed the use of gypsum (CaSO4 · 2H2O) as a skeleton builder for sludge dewatering since polymer conditioning of sludge affected only the rate of water release, not the extent of dewatering. The use of gypsum as a physical conditioner, in association with a polymer, could improve sludge filterability. More significantly, gypsum serves as a skeleton builder, forming a permeable and rigid lattice structure that can remain porous under high positive pressure during the compression step after the cake growth of the filtration, thereby maintaining the size of the micro‐passages through which water is expressed. Experiments using a high pressure cell apparatus showed that a further decrease of two to seven percent of the equilibrium moisture content of the sludge cake was achieved, for sludge thicknesses for dewatering of 1 to 10 cm, by the addition of gypsum with 60% of the original sludge solids when compared to the single polymer conditioning. The importance of the addition of gypsum in alum sludge dewatering is not only the improvement in the extent of dewatering, but also the potential application of transforming dewatered alum sludge from “waste” for landfill to useful “fertilizer” or to be used as a filter medium/adsorbent for wastewater treatment engineering.
Site-specific HU binding in the Mu transpososome: conversion of a sequence-independent DNA-binding protein into a chemical nuclease.

HU is a small, basic, sequence-independent DNA-binding protein capable of engineering DNA deformations required for the formation of higher order nucleoprotein structures. One such complex is the Mu Type 1 transpososome, where the ends of Mu are stably synapsed by a tetramer of Mu A and cleaved at their 3' ends. HU is believed to play a critical role in transpososome assembly, which requires the communication of the two Mu ends and the transpositional enhancer. Although footprinting studies have clearly defined the DNA regions bound by Mu A, no protection could be ascribed to the HU protein by DNAse I, MPE.Fe(II) or hydroxyl radical methods (Lavoie et al. 1991). To directly probe HU interactions with the transpososome DNA, we have coupled HU to a DNA cleavage reagent, iron-EDTA, and report here the first HU "footprint". HU-nuclease cleavage was detectable at specific sites within an 83-bp spacer DNA separating the left-end-most L1 site from its neighboring L2 site. This HU binding was specific since it could not be competed with 10-fold excess supercoiled DNA. We postulate that HU promotes the formation of a tight DNA bend or loop in this region which facilitates the communication of Mu A monomers during complex assembly. This method may prove generally useful for the localization of sequence-independent DNA-binding proteins on DNA and within higher oder nucleoprotein structures.
Tumor necrosis factor-alpha induces Cl- and K+ secretion in human distal colon driven by prostaglandin E2.

Increased levels of tumor necrosis factor-alpha (TNF-alpha) have been found in, for example, inflammatory bowel disease (IBD) and human immunodeficiency virus (HIV) infection. To investigate a possible contribution of TNF-alpha to the pathogenesis of diarrhea in these diseases, ion transport of human distal colon was studied in the Ussing chamber in vitro. Serosal addition of TNF-alpha increased short-circuit current (Isc) of partially stripped tissues in a dose-dependent manner. Maximum Isc increase of 1.8 +/- 0.2 mumol.h-1.cm-2 was reached after 60 +/- 9 min at 200 ng/ml TNF-alpha. Bidirectional tracer flux measurements revealed that TNF-alpha induced an increase in 36 Cl serosal-to-mucosal flux, a decrease in 36Cl- mucosal-to-serosal flux, and a slight increase in K+ secretion indicated by an increased secretory 86Rb net flux. In the highly differentiated colonic epithelial cell line HT-29/B6, TNF-alpha had no effect on Isc, suggesting a mediation step located in the subepithelium. This supposition was supported by measurements on totally stripped human tissues, since removal of subepithelial layers by total stripping reduced the TNF-alpha effect by 40%. Experiments with tetrodotoxin (10(-6)M) indicated that the TNF-alpha effect was not mediated by the enteric nervous system. The specific 5-lipoxygenase blocker ICI-230487 (5 x 10(-8)M) also had no effect on TNF-alpha action. In contrast, inhibition of cyclooxygenase by indomethacin (10(-6)M inhibited the effect of TNF-alpha. Radioimmunoassay of prostaglandin E2 (PGE2) in the serosal bathing solution revealed an increase in PGE2 production/release after addition of TNF-alpha, which paralleled the Isc response. We conclude that TNF-alpha changed Cl- and K+ transport toward secretion in human colon. This effect was mediated by PGE2 produced by subepithelial cells. Thus TNF-alpha could be a mediator of diarrhea during intestinal inflammation, e.g., in IBD and HIV infection.
Rethinking Assimilation Theory for a New Era of Immigration 1

Assimilation theory has been subject to intensive critique for decades. Yet no other framework has provided the social science community with as deep a corpus of cumulative findings concerning the incorporation of immigrants and their descendants. We argue that assimilation theory has not lost its utility for the study of contemporary immigration to the United States. In making our case, we review critically the canonical account of assimilation provided by Milton Gordon and others; we refer to Shibutani and Kwan's theory of ethnic stratification to suggest some directions to take in reformulating assimilation theory. We also examine some of the arguments frequently made to distinguish between the earlier mass immigration of Europeans and the immigration of the contemporary era and find them to be inconclusive. Finally, we sift through some of the evidence about the socioeconomic and residential assimilation of recent immigrant groups. Though the record is clearly mixed, we find evidence consistent with the view that assimilation is taking place, albeit unevenly.
A gene structure of testosterone 6 beta-hydroxylase (P450IIIA).

Genomic clones of a rat testosterone 6 beta-hydroxylase have been isolated and characterized as the first gene (P450/6 beta A) among P450IIIA subfamily. This gene spans about 25Kb and consists of 13 exons, which is the largest number of exons among cytochrome P-450 genes reported previously. The nucleotide sequence of the exon region showed high similarity to those of P450PCN2 and P450PCN1 cDNA (Gonzalez, F.J. et al. (1987) Mol. Cell. Biol. 2969-2974), but several replacements and deletions of nucleotide were found between the P450/6 beta A gene and both cDNAs, indicating the existence of multiple P450IIIA genes in rats.
A Lipolytic Action of Epinephrine and Norepinephrine on Rat Adipose Tissue in vitro. ∗

Summary Epinephrine and norepinephrine stimulate production of nonesterified fatty acids from rat adipose tissue when incubated in vitro in rat plasma, presumably by stimulating the hydrolysis of neutral fats within the tissue. Incubation under nitrogen markedly inhibits this effect of epinephrine and appears to increase production of fatty acids from control tissues. The d-isomers of epinephrine and norepinephrine are much less active in this system than the physiological 1-isomers. indicating a specificity in tissue response. Some implications of this lipolytic activity are discussed.
The changing nebula around the hot R Coronae Borealis star DY Centauri

Among the distinguishing characteristics of the remarkable hot R Coronae Borealis star DY Cen, which was recently found to be a spectroscopic binary, is the presence of nebular forbidden lines in its optical spectrum. A compilation of photometry from 1970 to the present suggests that the star has evolved to higher effective temperatures. Comparison of spectra from 2010 with earlier spectra show that between 2003 and 2010, the 6717 and 6730 u emission lines of [Sii] underwent a dramatic change in their fluxes suggesting an increase in the nebula’s electron density of 290 cm 3 to 3140 cm 3 from 1989 to 2010 while the stellar temperature increased from 19500 K to 25000 K. The nebular radius is about 0.02 pc, 60000 times bigger than the semimajor axis of DY Cen binary system. Rapid changes of stellar temperature and its response by the nebula demonstrate stellar evolution in action.
Eyelid closure in embryogenesis is required for ocular adnexa development.

PURPOSE Mammalian eye development requires temporary fusion of the upper and lower eyelids in embryogenesis. Failure of lid closure in mice leads to an eye open at birth (EOB) phenotype. Many genetic mutant strains develop this phenotype and studies of the mutants lead to a better understanding of the signaling mechanisms of morphogenesis. The present study investigates the roles of lid closure in eye development. METHODS Seven mutant mouse strains were generated by different gene ablation strategies that inactivated distinct signaling pathways. These mice, including systemic ablation of Map3k1 and Dkk2, ocular surface epithelium (OSE) knockout of c-Jun and Egfr, conditional knockout of Shp2 in stratified epithelium (SE), as well as the Map3k1/Jnk1 and Map3k1/Rhoa compound mutants, all exhibited defective eyelid closure. The embryonic and postnatal eyes in these mice were characterized by histology and immunohistochemistry. RESULTS Some eye abnormalities, such as smaller lens in the Map3k1-null mice and Harderian gland hypoplasia in the Dkk2-null mice, appeared to be mutant strain-specific, whereas other abnormalities were seen in all mutants examined. The common defects included corneal erosion/ulceration, meibomian gland hypoplasia, truncation of the eyelid tarsal muscles, failure of levator palpebrae superioris (LPS) extension into the upper eyelid and misplacement of the inferior oblique (IO) muscle and inferior rectus (IR) muscle. The muscle defects were traced to the prenatal fetuses. CONCLUSIONS In addition to providing a protective barrier for the ocular surface, eyelid closure in embryogenesis is required for the development of ocular adnexa, including eyelid and extraocular muscles.
Diagnostic value of high signal abnormalities on T2 weighted MRI in the differentiation of Alzheimer's, frontotemporal and vascular dementias

Objective – The occurrence of high signal abnormalities on T2 weighted images is strongly age related. The diagnostic value of these changes in a younger population with dementia is not currently known. We studied the potential of high signal changes on magnetic resonance imaging (MRI) in differentiating Alzheimer's disease (AD), frontotemporal dementia (FTD) and vascular dementia (VaD) in younger patients. Methods – High signal abnormalities were rated, using a previously validated scale, from hard copies of T2 weighted axial images of 102 patients with AD (n=49), VaD (n=31), FTD (n=22) (mean ages 63–65 years). Results – High signal abnormalities were widespread across AD, VaD and FTD. Although they were most frequent and most severe in the VaD group only lacunes and grade III deep white matter hyperintensities (DWMH) were specific for these patients. Conclusions – High signal changes on T2 weighted images on MRI are common across degenerative (AD and FTD) and vascular dementias. Although lacunes and grade III DWMH are specific for VaD, the low sensitivities (sensitivities: for lacunes, 0.32; for grade III DWMH, 0.16) limit their use as diagnostic markers for VaD. High signal changes on MRI should be interpreted with caution in dementias. Their presence, even in younger patients, should not deter one from diagnosing AD or FTD.
Analytical and Micromagnetic Study of Nonlinear Amplitude Modulation in Spintronic Modulators

A previous universal model of ¿combined¿ frequency-amplitude nonlinear modulation has been used to describe the spin-wave dynamics observed in spin-transfer oscillators. In that case, it was shown that it is not possible to obtain a pure frequency modulation process because the strict nonlinear relationship existing between the characteristic parameters of the oscillator yields a non-negligible amplitude modulation process to take place simultaneously. Here, we demonstrate that there exists a particular configuration in which a spin-torque oscillator behaves as a ¿pure¿ nonlinear amplitude modulator. For the case of a nano-contact geometry, for example, such a condition implies the usage of an external out-of-plane bias field directed along the critical angle at which the frequency tunability coefficient T = ¿f/¿I vanishes. In all those cases in which this coefficient is not zero, the previous combined process takes place. The phenomenon is first analyzed by developing an analytical model which describes the structure of the frequency spectrum of a nonlinearly amplitude modulated signal. Results of this approach are finally compared with those of micromagnetic investigations, carried out in time and frequency domains, deriving an excellent agreement.
Treatment of early childhood medulloblastoma by postoperative chemotherapy alone.

BACKGROUND The prognosis for young children with medulloblastoma is poor, and survivors are at high risk for cognitive deficits. We conducted a trial of the treatment of this brain tumor by intensive postoperative chemotherapy alone. METHODS After surgery, children received three cycles of intravenous chemotherapy (cyclophosphamide, vincristine, methotrexate, carboplatin, and etoposide) and intraventricular methotrexate. Treatment was terminated if a complete remission was achieved. Leukoencephalopathy and cognitive deficits were evaluated. RESULTS Forty-three children were treated according to protocol. In children who had complete resection (17 patients), residual tumor (14), and macroscopic metastases (12), the five-year progression-free and overall survival rates (+/-SE) were 82+/-9 percent and 93+/-6 percent, 50+/-13 percent and 56+/-14 percent, and 33+/-14 percent and 38+/-15 percent, respectively. The rates in 31 patients without macroscopic metastases were 68+/-8 percent and 77+/-8 percent. Desmoplastic histology, metastatic disease, and an age younger than two years were independent prognostic factors for tumor relapse and survival. Treatment strategies at relapse were successful in 8 of 16 patients. There were no major instances of unexpected toxicity. In 19 of 23 children, asymptomatic leukoencephalopathy was detected by magnetic resonance imaging. After treatment, the mean IQ was significantly lower than that of healthy controls within the same age group but higher than that of patients in a previous trial who had received radiotherapy. CONCLUSIONS Postoperative chemotherapy alone is a promising treatment for medulloblastoma in young children without metastases.
Selective impairment of T lymphocyte activation through the T cell receptor/CD3 complex after cytomegalovirus infection

Cytomegalovirus(CMV) infection is reported to cause transient immunosuppression in man. In this Study we have analysed ihe effect of CMV on T lymphocyte function in 29 children diagnosed for acute CMV infection. Peripheral blood mononuclear cells (PBMC) obtained from the palients showed a significant specific impairment in their proliferative response to enterotoxins A and C1. to coneanavalin A and to the anti‐CD3 MoAb OKT3. The impaired responses were corrected with exogenous IL‐2. In conlrast. slimulation using phytohaemagglutinin. as well as activation signals delivered through the surface molecules CD26 or CD28. elicited normal proliferalive responses in CMV PBMC. The results indicate that the T cell anergy associated with CMV infection is restricted to the T cell receptor/CD3 activation pathway.
18F-FDG PET/CT as an Indicator of Progression-Free and Overall Survival in Osteosarcoma

The aim of our study was to retrospectively evaluate whether maximum standardized uptake value (SUVmax), total lesion gylcolysis (TLG), or change therein using 18F-FDG PET/CT performed before and after initial chemotherapy were indicators of patient outcome. Methods: Thirty-one consecutive patients who underwent 18F-FDG PET/CT before and after chemotherapy, followed by tumor resection, were retrospectively reviewed. Univariate Cox regression was used to analyze for relationships between covariates of interest (SUVmax before and after chemotherapy, change in SUVmax, TLG before and after chemotherapy, change in TLG, and tumor necrosis) and progression-free and overall survival. Logistic regression was used to evaluate tumor necrosis. Results: High SUVmax before and after chemotherapy (P = 0.008 and P = 0.009, respectively) was associated with worse progression-free survival. The cut point for SUVmax before chemotherapy was greater than 15 g/mL* (P = 0.015), and after chemotherapy it was greater than 5 g/mL* (P = 0.006), as measured at our institution and using lean body mass. Increase in TLG after chemotherapy was associated with worse progression-free survival (P = 0.016). High SUVmax after chemotherapy was associated with poor overall survival (P = 0.035). The cut point was above the median of 3.3 g/mL* (P = 0.043). High TLG before chemotherapy was associated with poor overall survival (P = 0.021). Good overall and progression-free survival was associated with a tumor necrosis greater than 90% (P = 0.018 and 0.08, respectively). A tumor necrosis greater than 90% was most strongly associated with a decrease in SUVmax (P = 0.015). Conclusion: 18F-FDG PET/CT can be used as a prognostic indicator for progression-free survival, overall survival, and tumor necrosis in osteosarcoma.
Association of Cerebral Microbleeds With Cognitive Decline and Dementia.

IMPORTANCE Cerebral microbleeds are hypothesized downstream markers of brain damage caused by vascular and amyloid pathologic mechanisms. To date, whether their presence is associated with cognitive deterioration in the general population remains unclear. OBJECTIVE To determine whether microbleeds, and more specifically microbleed count and location, are associated with an increased risk for cognitive impairment and dementia in the general population. DESIGN, SETTING, AND PARTICIPANTS The Rotterdam Study, a prospective population-based study set in the general community, assessed the presence, number, and location of microbleeds at baseline (August 2005 to December 2011) on magnetic resonance imaging studies of the brain in 4841 participants 45 years or older. Participants underwent neuropsychological testing at 2 points a mean (SD) of 5.9 (0.6) years apart and were followed up for incident dementia throughout the study period until January 1, 2013. The association of microbleeds with cognitive decline and dementia was studied using multiple linear regression, linear mixed-effects modeling, and Cox proportional hazards. EXPOSURES Cerebral microbleed presence, location, and number. MAIN OUTCOMES AND MEASURES Cognitive decline measured by a decrease in neuropsychological test battery scores (Mini-Mental State Examination, Letter Digit Substitution Task, Word Fluency Test, Stroop test, 15-word Verbal Learning Test, and Purdue Pegboard Test) and compound scores (eg, G factor, executive function, information processing speed, memory, motor speed) and dementia. RESULTS In total, 3257 participants (1758 women [54.7%]; mean [SD] age, 59.6 [7.8] years) underwent baseline and follow-up cognitive testing. Microbleed prevalence was 15.3% (median [interquartile range] count, 1 [1-88]). The presence of more than 4 microbleeds was associated with cognitive decline. Lobar (with or without cerebellar) microbleeds were associated with a decline in executive functions (mean difference in z score, -0.31; 95% CI, -0.51 to -0.11; P = .003), information processing (mean difference in z score, -0.44; 95% CI, -0.65 to -0.22; P < .001), and memory function (mean difference in z score, -0.34; 95% CI, -0.64 to -0.03; P = .03), whereas microbleeds in other brain regions were associated with a decline in information processing and motor speed (mean difference in z score, -0.61; 95% CI, -1.05 to -0.17; P = .007). After a mean (SD) follow-up of 4.8 (1.4) years, 72 participants developed dementia, of whom 53 had Alzheimer dementia. The presence of microbleeds was associated with an increased risk for dementia after adjustment for age, sex, and educational level (hazard ratio, 2.02; 95% CI, 1.25-3.24), including Alzheimer dementia (hazard ratio, 2.10; 95% CI, 1.21-3.64). CONCLUSIONS AND RELEVANCE In the general population, a high microbleed count was associated with an increased risk for cognitive deterioration and dementia. Microbleeds thus mark the presence of diffuse vascular and neurodegenerative brain damage.
Analyzing aspects of cyber security standard for M&CS

The worry about M&CS security is getting more serious as M&CS have become close to the outer networks by employing information technologies. Against the threats like cyber attacks, standardization of M&CS security measures are being worked out recently . However, it is often hard for users to know which standard or guideline to follow in actual development. We have decided to provide reference documents that provide an overview of security standards and guidelines including their features.
Linewidth and Chirp of MEMS-VCSELs

This letter analyzes the influence of micromachined Bragg mirrors within active Fabry-Perot cavities on basic laser characteristics, like linewidth and chirp. The impact of thermal noise of the micromechanic structure is discussed and its influence on the linewidth of a microelectromechanical system (MEMS)-tunable vertical-cavity surface-emitting laser (VCSEL) is verified in an experiment. For the first time, we demonstrate for a MEMS-VCSEL a record low average linewidth of 210 MHz and extract an intrinsic linewidth of below 30 MHz. The second issue deals with the influence of microforces like radiation pressure, radiometric pressure, and length extension of the Bragg-mirror structure due to absorption on the chirp behavior of a MEMS-laser. For the first time, these effects and their influence on the VCSEL dynamics are modelled and discussed in detail. Further, the measured chirp characteristics are analyzed and compared with our modelling to quantify the influence of above effects on the device characteristics
Transfusion medicine problems and solutions for the pediatric hematologist/oncologist

Blood component transfusion is an integral part of the care of children with oncologic and hematologic conditions. The complexity of transfusion medicine may however lead to challenges for pediatric hematologists/oncologists. In this review, three commonly encountered areas of transfusion medicine are explored. The approach to the investigation and management of suspected platelet refractoriness is reviewed. The unique transfusion related challenges encountered by children undergoing stem cell transplantation are also discussed. Finally, issues arising out of the care of children with hemoglobinopathies are explored, with an emphasis on the incidence of allo‐ and autoimmunization. Pediatr Blood Cancer 2012; 58: 1106–1111. © 2012 Wiley Periodicals, Inc.