Miracle-dz/UniFAR-FTUs huggingface dataset:
Interrelationships between molecular subtype, anatomical location, and extent of resection in diffuse glioma: a systematic review and meta-analysis

Abstract Background The introduction of the 2016 WHO Classification of Tumors of the Central Nervous System has resulted in tumor groupings with improved prognostic value for diffuse glioma patients. Molecular subtype, primarily based on IDH-mutational status and 1p/19q-status, is a strong predictor of survival. It is unclear to what extent this finding may be mediated by differences in anatomical location and surgical resectability among molecular subgroups. Our aim was to elucidate possible correlations between (1) molecular subtype and anatomical location and (2) molecular subtype and extent of resection. Methods We performed a systematic review of literature searching for studies on molecular subtype in relation to anatomical location and extent of resection. Only original data concerning adult participants suffering from cerebral diffuse glioma were included. Studies adopting similar outcomes measures were included in our meta-analysis. Results In the systematic analysis for research questions 1 and 2, totals of 20 and 9 studies were included, respectively. Study findings demonstrated that IDH-mutant tumors were significantly more frequently located in the frontal lobe and less often in the temporal lobe compared with IDH-wildtype gliomas. Within the IDH-mutant group, 1p/19q-codeleted tumors were associated with more frequent frontal and less frequent temporal localization compared with 1p/19q-intact tumors. In IDH-mutant gliomas, greater extent of resection was achieved than in IDH-wildtype tumors. Conclusions Genetic profile of diffuse cerebral glioma influences their anatomical location and seems to affect tumor resectability.
A Critical Look at Participation of Persons with Mental Health Problems in Training Mental Health Professionals within University Education

Involvement of persons with mental health disorders, with or without addictions (persons with MHA), within mental health education is becoming more common in some parts of the western world, in particular, the United Kingdom. What does involving persons with MHA entail and what are the benefits and challenges in involving these individuals in education? In this paper, we take a critical look at involvement of persons with MHA within the literature and provide a case study of a Canadian inter-professional mental health and addictions course where persons with MHA were included in some aspects of teaching. We present the evaluation of the course, and offer implications for involvement of persons with MHA in university courses.
Transfers of Patient Care: An Exploration of the Nurses’ Process

The purpose of this study is to analyze the nurses transfer process as patients transferred from the ICU to general medical surgical units in a large academic medical center, and to explore the data elements that nurses define as essential to safe and effective transfer of patient care, including factors that may impact the optimal delivery of the handoff information. Data were collected through observations of the ICU and medical surgical unit nurses, interviews of the nurses regarding current and ideal processes surrounding patient transfers, and chart reviews of data elements related to transfer outcomes. Results of this study explore the types of activities nurses perform preand posttransfer and compare those activities to the described actual and described ideal processes identified by the nurses in interviews. Elements of information included in the handoff communication were observed and documented, then compared to the stated actual and ideal information according to the respondents. Although sequence of transfer components varied in both the observed activities and the described activities, the preand post-transfer processes were able to be categorized. Interview responses were analyzed using a modified version of Spradley’s Domain Analysis (1979). Two of the nine defined semantic relationships were found to be present: (a) spatial where X is a part of Y, and (b) attribution where X is an attribute of Y. This relationship analysis enabled understanding of the interviews across responses.
The Influence of the Myricetin on the Liver, Kidney, Spleen and Some Endocrine Glands of Male Rats at Prepubertal Period

Bu calismada, dogum sonrasi (PND) 23'ten 53'e gune kadar cesitli dozlarda myrisetine maruz kalmanin etkileri incelenmistir. Erkek sicanlar her grup alti hayvandan olusan bes gruba ayrildi. Sicanlar, misir yagi suspansiyonu icinde 25 ve 50 mg/kg/gun dozlarimda myricetin ile muamele edildi. Pozitif kontrol grubuna oral olarak 0,7 ve 7 µg/kg/vucut agirligi gun dozlarinda 17α-etinil estradiol ve normal kontrol grubuna mide tupu ile misir yagi verildi. Calismanin sonunda karaciger, bobrek, dalak, pankreas, timus ve adrenal bez agirliklari olculdu. Organ/ vucut agirlik oranlari hesaplandi ve doku kesitleri histolojik olarak incelendi. Karacigerde TUNEL metodu uygulandi ve degerlendirildi. Sonuc olarak, mutlak karaciger agirliklari, yag kontrol grubuna kiyasla 0,7 ve 7µg/kg/gun etinil estradiol ve 50mg/kg/gun myrisetin uygulama gruplarinda istatistiksel olarak azaldi. Karaciger, bobrek ve dalagin histopatolojik incelemesinde, kontrol grubuyla karsilastirildiginda, konjesyon, hucre dejenerasyonu ve mononukleer hucre infiltrasyonu sikliginda anlamli artis oldugu goruldu. Ayrica myrisetin doz gruplarinda, apoptotik hucreler artti. Bu calisma, peripubertal donemden pubertal doneme agizdan mide tupu ile verilen mirisetinin erkek sicanlarin karaciger, bobrek, dalak ve endokrin bezleri uzerinde olumsuz etkilere neden oldugunu gostermistir.
Study of type 2 diabetes management among patients in a Macau primary care setting

Background In the primary care setting in Macau, type 2 diabetes mellitus (T2DM) is the seventh most common reason for consultation. Inadequate glycaemic control constitutes a major public health problem and is associated with premature death and disability and decreased quality of life. Moreover, this condition substantially increases healthcare expenditures. Objective The primary objective was to assess the successful glycaemic control rates, blood pressure (BP) and cholesterol control rates in patients with T2DM in a Macau primary care setting. The secondary objective of this study was to assess the delay of insulin initiation in the Sao Lourence Health Center. Methods Patients were stratified according to age (<65 years vs ≥65 years) and sex. Successful glycaemic control was defined as glycated haemoglobin (HbA1c) <7%. Successful cholesterol control was defined as a low-density lipoprotein cholesterol (LDL-C) level <2.6 mmol/L, and BP control was defined as BP <140/90 mm Hg. Results Among the 2157 participants included in this study, 1046 (48.5%) patients had HbA1c <7%, 1209 (56.1%) patients had BP <140/90 mm Hg and 1244 (57.7%) patients had LDL-C <2.6 mmol/L. In conclusion, only 403 (18.7%) patients met the targets for all three measures. Of the 235 patients who were on insulin therapy, the mean (±SD) duration from T2DM diagnosis to insulin initiation was 7.47±6.52 years, the mean (±SD) duration from HbA1c not meeting the target (HbA1c ≥7% over 1 year and persistently) to insulin initiation was 3.34±3.66 years and the mean baseline HbA1c was 9.13%. Compared with patients with a longer duration (≥5 years) of HbA1c not meeting the target before insulin initiation, those who started insulin within 1 year of HbA1c not meeting the target had a better glycaemic control rate (40.7% vs 13%). Conclusions Nearly half of the patients at Sao Lourence Health Center, a primary care centre in Macau, met the glycaemic control target, but less than one-fifth of patients met all three targets for T2DM control. Moreover, there was a delay in insulin initiation for people with T2DM.
Evaluation of Discordance between 10 year Cardiovascular Risk Scores in Indian Patients presenting with Myocardial infarction

Background: Cardiovascular diseases are rapidly emerging as major cause of mortality and disability in India. Existing Risk Calculators for Cardiovascular Risk have not undergone appropriate validation in Indian Patients. Present Study was undertaken to compare different cardiovascular calculators for CVD risk assessment models in Indian patients presenting with first episode of myocardial infarction. Methods: This study included 150 patients presenting with first episode of myocardial infarction (MI). 10-year risk of CVD was calculated using three risk assessment models Framingham Risk score (Risk FRS), Revised American College of Cardiology/American Heart Association (Risk ACC/AHA) and WHO Risk Prediction Charts.Results: Risk FRS recognized the highest number of patients (74%) at high CVD risk (>20% 10 yr CV Risk) while Risk ACC/AHA and WHO ISH Risk calculators provided inferior risk discrimination. Risk FRS and Risk ACC/AHA had good correlation (Pearson's r 0.93, p<0.001) but poor agreement when divided into Subcategories (Kappa =0.022). Conclusion: FRS seems to be as most useful CVD risk assessment tool in identification of Indian patients at high Cardiovascular Risk.
Scaffolding the Attention-Deficit/Hyperactivity Disorder Brain Using Random Noise Stimulation

Various methods have been attempted to effectively ameliorate psychiatric and neurological conditions in children and adults. One of the attractive ideas is to develop interventions to create a lasting, rather than only an immediate, effect. Neurostimulation has been shown to yield long-term effect when combined with cognitive training in healthy young adults. We examined whether such approach could benefit children with attention deficit hyperactivity disorder (ADHD), the most common neurodevelopmental disorder in childhood. We used a randomized double-blind active-controlled crossover study of 19 unmedicated children (aged 7–12 years old) with attention deficit hyperactivity disorder, who received either transcranial direct current stimulation or random noise stimulation while completing five-day executive functions training, which includes working memory, cognitive flexibility, and inhibition tasks. Both stimulation protocols have previously shown potential for inducing lasting benefits in adults, while transcranial direct current stimulation was examined in multiple attention deficit hyperactivity disorder studies and has been highlighted as a promising method for treating neuropsychological deficits. For our primary outcome, transcranial random noise stimulation yielded a clinical improvement as indicated by the reduced attention deficit hyperactivity disorder rating scale score from baseline, and in comparison to the changes observed in transcranial direct current stimulation. Moreover, the effect of brain stimulation one week after completion of treatment yielded further improvement, suggesting a neuroplasticity-related effect. Finally, transcranial random noise stimulation improved working memory compared to transcranial direct current stimulation, and a larger transcranial random noise stimulation effect on attention deficit hyperactivity disorder rating scale was predicted for those patients who showed the greatest improvement in working memory. Our results provide a promising direction toward a novel intervention in attention deficit hyperactivity disorder, which is shown to have a lasting effect via the modulating of neuroplasticity, rather than a merely immediate effect as was shown for in previous medical interventions.
Eficacia y seguridad de tratamiento secuencial de largo plazo contra la obesidad con anorexigénicos catecolaminérgicos en liberación lenta

Objective. To evaluate the efficacy and safety of sequential long-term treatment for obesity with slow release catecholaminergic anorexigenics. Material and methods. A randomized double-blind study with placebo control of 14 months, six months crossed with crosses: placebo fenproporx more dizepam, amfepramona to fenpropore, fenproporex to mazindol and diazepam fenproporex more to D-norpseudoephedrine; to evaluate the safety and efficacy of sequential treatment, in which 120 patients (30 per arm) were included. Results. The results indicate that all combinations significantly decrease the weight (in kilograms absolute and percentage), BMI, fat (kilograms and percentage), waist circumference; and biochemical parameters; however, combination (in sequence) of fenproporex to mazindol was the most effective reduction, although all combinations showed both efficacy and safety in drug treatment as part of integrated management (diet and exercise) of obesity. Conclusion. This study helps support the sequential therapeutic strategy for antiobesity long-term treatment (14 months).
The clinical spectrum of multiple endocrine neoplasia type 2a caused by the rare intracellular RET mutation S891A.

BACKGROUND Germline missense mutations of the RET protooncogene cause a clinical spectrum called multiple endocrine neoplasia (MEN) type 2. A strong genotype-phenotype correlation results in major implications for the clinical approach. More information on less common mutations is needed to advance specific guidance. PATIENTS AND METHODS We report individualized patient information on 36 carriers of the intracellular RET gene mutation S891A from three centers and clustered data of 38 former patients reported in the literature in nine additional studies. RESULTS S891A mutation accounts for up to 5% of all patients to date reported with RET mutations and 16% of those hitherto reported with intracellular mutations. S891A mutation caused medullary thyroid cancer (MTC) in 69.4%, pheochromocytoma in 2.8%, and parathyroid hyperplasia in 8.3% of the 36 patients of this case series and in 63.5, 4.1, and 4.1%, respectively, for the entire groups of 74 patients. The youngest age of onset for MTC in this group was 17 yr (median, 46 yr; range, 17-80 yr), for pheochromocytoma 46 yr (median, 46 yr), and for parathyroid hyperplasia 17 yr (median, 20 yr, range, 17-46 yr). Persistence of MTC was described in 14.3% of patients with available follow-up. Additional findings included corneal nerve thickening in three of 74 patients (4.1%). CONCLUSION This intracellular mutation can initiate the full spectrum of MEN2a, initiates MTC at an early age, and causes recurrence and death if undertreated. We recommend stringent adherence to established guidance in MEN2a in this rare mutation.
Alcohol misuse in older people

Summary The clinical and public mental health aspects of alcohol misuse in older people (both men and women) have increasing relevance for both old age and addiction psychiatrists. Clinical presentations are often complex and involve a number of different psychiatric, physical and psychosocial factors. The assessment, treatment and aftercare of alcohol-related and comorbid other mental disorders will also involve a broad range of interventions from a wide range of practitioners. Given its growing clinical relevance, there are particular areas, such as alcohol-related brain damage and drug interactions with alcohol, that deserve special attention.
ANTIMICROBIAL ACTIVITY OF DIFFERENT CONCENTRATIONS OF ESSENTIAL OIL OF ZATARIA MULTIFLORA ON ENTEROCOCCUS FAECALIS

Statement of Problem: The main goal of endodontic treatment is eradication of microorganisms and their byproducts from the root canal system. The use of chemical irrigants during chemo-mechanical canal preparation is important for disinfection and cleaning of the canal system. Purpose: The aim of this in vitro study was the assessment of bacterial growth after contact with several concentrations of essential oil of Zataria multiflora in varying time intervals. Materials and method: The essential oil of Zataria multiflora were serially diluted 8 folds and a fixed volume of the stationary phase culture of E.faecalis was added to each diluted solution, for varying intervals of 1, 5 and 15 minutes. 100µl of the contents of each tube were transferred to SF broth and incubated for 48h at 37 0 c. Results of bacterial growth were recorded at the end of the incubation period. Results: 2% solution of essential oil of Zataria multiflora at all intervals inhibits growth of E.feacalis. 1% solution of it showed antibacterial effect in 5, and 15 minutes. The concentrations under 0.5% dilution of Zataria multiflora did not eliminate E.faecalis at any time intervals. Conclusion: It seems that 1% and 2% solutions of essential oil of Zataria multiflora were effective at destroying E.faecalis. Application of this plant essential oil may be recommended for root canal irrigant following extensive ex-vivo and in-vivo experiments. Key words: Essential oil of Zataria multiflora, Enterococcus faecalis, antimicrobial activity
Radiochirurgie Gamma Knife des schwannomes du nerf facial.

schwannomes du nerf facial (VII) comporte un risque tres eleve de paralysie faciale severe postoperatoire. Etant donne le caractere exceptionnel des paralysies faciales apres radiochirurgie Gamma Knife(GK) des schwannomes cochleo-vestibulaires l'evaluation de la preservation fonctionnelle du VII apres GK nous est apparue d'importance, dans ce groupe de patients difficiles. Material et methode. - Parmi 1 000 schwannomes du paquet acoustico-facial operes par GK a Marseille entre juin 1992 et mars 2003, 9 ont ete consideres comme des schwannomes du nerf facial. Les criteres pour ce diagnostic etaient l'envahissement de la deuxieme ou troisieme portion du canal du VII (7 fois), et/ou une constatation operatoire prealable (2 fois). Les rares paralysies faciales apres GK des schwannomes du VIII survenant classiquement avant le 18 e mois, ont ete consideres comme evaluables les patients suivis plus de 2 ans (8 patients). Resultats. - Quatres de ces patients avait fait l'experience d'une paralysie faciale aigue spontanee, une (3 patients) ou plusieurs fois (1 patiente) avant la radiochirurgie. La fonction facial n'etait normale que dans 2 cas avant la GK (House 2: 6 fois; House 3: une fois). Le suivi est de 2 a 7 ans pour les 8 patients evaluables. Aucun de ces patients n'a developpe ou aggrave une paralysie faciale. Deux patients ont fait l'experience d'une amelioration de leur paralysie faciale pre-radio-chirurgicale. Tous ces patients sont actuellement controles d'un point de vue tumoral. La specificite et l'heterogeneite de ce groupe nous ont amenes a decrire une classification originale en 4 types, differents par les problemes cliniques et chirurgicaux poses. Conclusion. - Cette etude demontre que la radiochirurgie Gamma Knife permet de traiter ces patients, tout en conservant la fonction faciale. Un tel avantage du GK en fait le traitement rationnel de premiere intention pour tout schwannome du facial de petite ou moyenne taille.
Subaraknoidalblødning er fremdeles en meget alvorlig sykdom

Materialet er pasienter innlagt i Nevrologisk avdeling, Vestfold sentralsykehus, som mottar samtlige pasienter med erkjent subaraknoidalblødning i fylket. Antall pasienter som døde før de nådde sykehus er ikke medregnet eller forsøkt vurdert, men ut fra litteraturen er det i størrelsesorden 15% (2, 3). Det er videre rimelig at eldre pasienter vil være underregistrert, men aldersfordelingen i pasientmaterialet tyder på at det ikke mangler så veldig mange pasienter i høy aldersgruppe. Endelig vil det være noen som har udiagnostisert subaraknoidalblødning uten å være innlagt i sykehus og uten å dø av det. Tallmaterialet gir dermed en minimumsinsidens av subaraknoidalblødning på 8,1 per 100000 personer per år. Dette tilsvarer insidensen i Sverige, men ligger langt under den finske insidensen på 21,4, som er antatt å henge sammen med genetiske forhold og høy prevalens av arteriell hypertensjon.
Volumetric magnetic resonance imaging of gastrocnemius muscle in a patient with facioscapulohumeral dystrophy

__________________________________________________________________________________________ Introduction: Magnetic resonance imaging (MRI) is a nonradiographic, non-invasive method to visualize and quantify muscle cross-sectional areas and volumes. Purpose: To evaluate a gastrocnemius muscle volume in a 15-year-old male with facioscapulohumeral dystrophy (FSHD) using MRI. Material and methods: The patient with FSHD was given subcutaneously recombinant human granulocyte colony-stimulating factor filgrastim (5μg/kg body/day) for 5 consecutive days during the first, second, and third months. The Siemens Magnetom 0.3T MRI scanner was used to acquire the images of the right calf of the patient. The analysis of MR images used advanced biomedical imaging software-Analyze 10 Biomedical Imaging Software. Results: The patient with FSHD after 6 month of the treatment compared with baseline had greater volume of the gastrocnemius muscle volume of the right calf. Muscle volume increased from 60,567.5 mm to 70,795.6 mm. The increased of muscle volume of this patient correlated with the improvements of muscle strength and EMG. Conclusion: MR imaging can provide quantitative, reproducible volumetric measures of muscles in the patients with FSHD.
The effect of education of cardiopulmonary resuscitation (C.P.R) on knowledge of nursing staff and C.P.R team members in a hospital in Kerman province

Approximately half of the cardiac arrest mortality occurred in hospitals and nurses are one of the key persons in acceptance duty. For proper performing resuscitation nurses have to have theoretical knowledge and practical skill. Literature review shows knowledge as well as skill deficiency among nurses in this topic. To investigate the effect of CPR education by booklets and brushers on knowledge of Emergency staffs and members of CPR team in one Kerman province hospital at2008. In this quasi-experimental study، to assess CPR knowledge a questionnaire consists of 15 items was used. After confirming the validity and reliability، it was distributed among participants (CPR team and emergency ward staffs). After pretest، booklets and brushers (according to the new protocol of CPR for each part of subject) were distributed among participants. Post test was done after 8 days and data were analyzed by SPSS17. According to the results، after education، knowledge scores of staff about CPR was significantly more than that of before education (P<0.001). Mean of knowledge scores of ICU and CCU nurses in both pre test and post test were higher than that of others (P<0.001). It can be concluded that education، even if it would be inexpensive and brief، has positive effect on improvement of nurses’ knowledge. This study highlights the role of education in development of competency and confident of nurses in the topic of CPR Keywords: Education, knowledge, Cardiopulmonary Resuscitation team, nurse
Sociodemography, Oral Health Status and Behaviours Related to Oral Health Literacy

Objective: To assess the relationships of socio-demography, self-reported oral health status, and behaviour with oral health literacy (OHL) among adults. Material and Methods: A cross-sectional study was conducted during a mega carnival in Kuala Lumpur. Socio-demographic, oral health status, and oral health behaviour data were obtained using a questionnaire, and OHL was determined by a validated Malay version of the 14 items Health Literacy in Dentistry Scale (HeLD-14). A total of 165 data of participating adults were tested using Pearson’s correlation, Independent t-test and One-way ANOVA with a significance level set at p<0.05. Results: The mean age of participants was 30.4 years (S.D. 9.7 years). Malay HeLD-14 scores were higher among those who were from better socio-economic class (household income within the top 20% of the population) (p<0.005) those with good self-reported oral health status (good oral health status, no active caries) (p<0.005) and those with good oral health behaviours (brushed daily, flossed daily, does not vape) (p<0.05). Conclusion: Household income, self-reported oral health status, and behaviours were significantly associated with oral health literacy. Therefore, oral health literacy assessment is vital to help tailor appropriate oral health education and care.