Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of Topical 5-Fluorouracil for Keratocystic Odontogenic Tumors of Gorlin-Goltz Syndrome as a New Targeted Therapy: A Case Report and Review of Literature

cystic Odontogenic Tumors of Gorlin-Goltz Syndrome as a New Targeted Therapy: A Case Report and Review of Literature Hossein Shiran1 * , SH Shafaei Fard2, S Hakimi3, A Azari Pour Esfahani1 1Postgraduate Student, Oral and Maxillofacial Surgery Dept, faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran 2Associated Professor, Oral and Maxillofacial Surgery Dept , faculty of Dentistry, Tehran Medical Sciences,, Islamic Azad University, Tehran, Iran 3Associated Professor , Oral and Maxillofacial Surgery Dept, faculty of Dentistry,Medical Sciences University of Zahedan,Iran
Gynecologic Issues in the

With the advent of highly active antiretroviral therapy (HAART), women living with HIV can now enjoy longer life spans in relative good health as well as the prospect of bearing children with an overwhelmingly low risk of vertical transmission. Thus, increasingly, seropositive women are now facing issues around longevity as well as those associated with fertility. The clinician caring for the HIV-infected woman must be alert to the gynecologic issues that are prevalent in this population. Among those faced by the gynecologist are menstrual abnormalities, lower genital tract neoplasia, sexually transmitted infections, the need for gynecologic surgery, and menopausal issues including osteopenia/osteoporosis. Contraception in HIV seropositive women presents unique management issues, because of the necessity for a dual role of prevention of both pregnancy and HIV transmission, the possible effect of birth control on HIV infection, and the interaction between birth control and HIV therapies. With ever-increasing frequency, the gynecologist will be presented with the seropositive woman or couple who wishes to conceive. The purpose of this article is to review the current knowledge on the relationship between HIV infection and menstrual abnormalities, genital neoplasias, contraceptive options, surgical complications, and menopause with its associated disorders. Special considerations in the seropositive woman contemplating pregnancy will also be discussed. The treatment of pelvic infections is discussed elsewhere in this volume, and only changes in standard therapy because of concurrent HIV infection will be discussed here.
Pemanfaatan Ekstrak Kubis Ungu (Brassica Oleraceae) Sebagai Indikator Warna Pada Analisis Hidrokuinon

Abstract Purple cabbage has distinctive color which is purple due to anthocyanin. Anthocyanin is natural pigmen that has high sensitivity in color change every level of pH changes acid to base. The anthocyanin sensitivity can be used color indicator. The purpose of this research is utilization purple cabbage extract as color indicator hydroquinone analysis. The research method in this research is maceration extract by executing optimizations such as temperatur optimization and optimization of maceration time. Based on the results of the research has obtained regression equation y = 0,001x + 0,0574 with a value or R=0,947. It can be concluded that purple cabbage extract can be used as color indacator on hydroquinone analysis Kata kunci: Purple Cabbage ( Brassica Oleraceae ), Color indicator, Hydroquinone. Abstrak Kubis ungu mempunyai warna khas yaitu warna ungu yang disebabkan oleh zat antosianin. Antosianin merupakan pigmen alami yang mempunyai sensitifitas tinggi dalam perubahan warna disetiap tigkat perubahan pH dari asam ke basa. Kepekaan antosianin tersebut dapat dijadikan indikator warna. Penelitian ini bertujan untuk memanfaatkan ekstrak kubis ungu sebagai indikator warna pada analisis hidrokuinon. Metode yang digunakan dalam penelitian ini adalah ekstraksi maserasi, dengan melakukan beberapa optimasi diantaranya optimasi optimasi suhu dan optimasi waktu maserasi. Berdasarkan hasil penelitian diperoleh persamaan regresi y = 0,001x + 0,0574 dengan nilai R = 0,947, dapat disimpulkan bahwa ekstrak kubis ungu dapat dijadikan sebagai indikator warna pada analisis hidrokuinon. Kata kunci: Ekstrak kubis ungu, Indikator warna, Hidrokuinon.
A System for Assessing Cervical Readiness Using Analytics and Non-Invasive Evaluation (Crane)

Current cervical spine assessment methodologies focus solely on subjective measures, such as pain reports, and range-of-motion (ROM) testing that only measures maximum head excursion and reach (i.e., not dynamic motion). Due to report bias and the potential for negative outcomes of self-reported pain, current clinical assessment methods fail to provide valid, reliable data for medical practitioners to effectively manage long-term cervical health. Furthermore, commercial systems capable of quantitative assessment of cervical spine function are generally sparse and often immature. This paper highlights both the need and a path towards a clinical tool for objective measurement of cervical spine health and functionality. Lastly, a novel solution concept is presented to objectively assess Cervical Readiness using Analytics and Non-invasive Evaluation (CRANE). This solution concept combines cervical spine instrumentation, novel virtual reality (VR) game-based test protocols, robust analytical algorithms, and intuitive presentation of health metrics.
Experimentation of acute injured spinal cord by transplanting the bone marrow stromal cells

Objective: In this study, bone marrow stromal cells (BMSCs) were transplanted in situ after spinal cord injury (SCI) in rats. It was proved that the implanted BMSCs could differentiate into neuron-like cells in the injured spinal cord, and the long-term motor ability test was carried out to investigate the recovery of neurological dysfunction after transplantation. Methods: (1) An improved Alien’s SCI rat model (weight 10 g, height 30 mm) was made by Alien weight drop method. Methyl eosin (Haematoxyli - n/eosin, HE) was used to identify with SCI. (2) The BMSCs were identiﬁed by the method of bone marrow adherent culture in vitro. The morphology of the cells was observed by cell staining, and CD44 was detected by BMSCs. After three cultures, the cells were transfected with lentiviral vectors carrying Green Fluorescent Protein (GFP) gene. (3) Cell survival after passage and transplantation: the GFP labeled BMSCs in situ (injury zone) were implanted into the injury model. The spinal cord sections were sacriﬁced after 2 weeks (2w), 4 weeks (4w) and 6 weeks (6w) respectively, and the cells expressing GFP were observed under immunoﬂuorescence microscope. (4) The modiﬁed Rivlin oblique plate test and spinal motor function blood brain barrir (BBB) score method were used to compare the changes of exercise ability in the simple injury group, 2w after transplantation group, 4w after transplantation group and 6w after transplantation group. Results: (1) The Alien’s SCI rat model was made by using Alien’s heavy drop method, and the effect was reliable and stable. (2) The proliferation of BMSCs after 3 passages has stabilized. After culture and ampliﬁcation in vitro, the cell morphology changed to be conical, protruding interwoven into a network. Therefore, it could be used as a source of cell transplantation after SCI. The morphology of the cells was observed by staining, and the positive CD44 was detected. (3) BMSCs were transfected into the SCI model by lentiviral vector carrying GFP gene, and the expression of GFP in 6w was observed. (4) The results of modiﬁed inclined plane test and Rivlin locomotor BBB score of rats in simple injury group were signiﬁcantly worse than those in transplantation control group ( p < .05). 2w, 4w and 6w after transplantation groups could improve long-term motor function. The recovery of neurological dysfunction after 6w was the best, and the difference was statistically signiﬁcant ( p < .05). Conclusions: BMSCs transplantation could promote the recovery of neurological dysfunction after SCI, and the mechanism may be related to the differentiation of BMSCs into neurons and glial cells, and the BMSCs induced by transplantation could interact with peripheral nerve cells and produce some cytokines.
AVALIAÇÃO SENSÓRIO-MOTORA E SUA CORRELAÇÃO COM A QUALIDADE DE VIDA EM PORTADORES DE DIABETES MELLITUS.

Introducao: Diabetes Mellitus (DM) e uma doenca metabolica com alteracoes e complicacoes que se caracterizam pela falta de insulina e/ou da incapacidade da insulina de ser secretada pelo pâncreas. A neuropatia diabetica e a mais frequente complicacao do diabetes mellitus que afeta as extremidades e, principalmente, os membros inferiores, causando o pe diabetico. Objetivos: Avaliar a sensibilidade, motricidade do pe diabetico e a qualidade de vida dos pacientes portadores de Diabetes Mellitus. Materiais e Metodos: Pesquisa quantitativa, do tipo descritiva, realizada na cidade de Porto Velho. Amostra selecionada de maneira nao probabilistica, com 07 pacientes com faixa etaria de 30 a 80 anos. Os instrumentos utilizados para a coleta de dados foram as fichas do pe diabetico, testes de sensibilidades com o uso de monofilamentos e circuitos, avaliacao da forca dos musculos dos pes e amplitude de movimento com o uso do goniometro e alteracoes de qualidade de vida atraves do questionario SF – 36. Resultados e Discussao: Verificou-se que houve alteracoes de sensibilidade e motricidade dos pacientes avaliados, e quanto mais tempo de diagnostico da doenca pior os sinais e sintomas apresentados. Alteracoes de qualidade de vida como dor, aspectos sociais, limitacoes fisicas, vitalidade e aspectos emocionais. A fisioterapia tem um papel importante na prevencao de alteracoes de sensibilidade e motricidade no pe diabetico, e atua orientando os pacientes em relacao aos cuidados com os pes, treino de equilibrio e marcha, atuando tambem na melhora ou manutencao de forca muscular. Palavras - chave : Neuropatia Diabetica, Fisioterapia, Diabetes Mellitus.
Missed Clavicular Fracture in an Adult without Head Injury or Polytrauma Review of Literature and a Rare Case

We present a case of missed clavicular fracture in a patient with an associated wrist fracture but without head injury. This is the first case of missed clavicular fracture in an adult, despite adequate imaging, and without head injury presenting two days after the patient was discharged after fixation of the distal radius fracture.
Percepciones de las Mujeres Mexicanas Sobre el Uso de Métodos Anticonceptivos

Introducción: Más del 50% de los embarazos a nivel mundial son no planeados. El 99% de los embarazos no planeados se presentan en países en desarrollo, el 38% de estos en América Latina y el Caribe. Métodos: Se realizó un estudio cualitativo, a través un análisis de contenido congruente con la descripción cualitativa. Se realizaron entrevistas semiestructuradas a mujeres de 18 a 24 años de edad. Resultados: La angustia por un cambio de vida, el tener planes para el futuro y una relación formal mayor a un año son los principales motivos para usar un método anticonceptivo de forma correcta y consistente. Las barreras reportadas para el uso de métodos anticonceptivos fueron los efectos secundarios, las creencias de los padres acerca de la sexualidad y la reproducción y el estigma hacia las mujeres que usan métodos anticonceptivos. Conclusiones: Las principales barreras en las mujeres son las de tipo cultural. Los hallazgos muestran que la influencia de la red social es más importante que las creencias individuales. Por lo que se debe de incluir al personal de salud y la comunidad en las intervenciones de salud.
Evaluating The Virtues Project as a leadership development programme

This article contributes to an emerging field of virtue-based leadership development scholarship by reporting on the first known empirical evaluation of The Virtues Project as a leadership development programme. This exploratory study seeks to understand if or how The Virtues Project might facilitate the development of good leaders. Our understanding of ‘good’ is informed by the notion of virtue and the philosophy of virtue ethics, and we adopt a critical realist evaluation framework to distil what about The Virtues Project works for whom in which contexts and why. Our study employs a longitudinal comparative case design composed of multiple in-depth interviews with nine leader participants and their colleagues over the duration of five months. Findings indicate that (a) The Virtues Project training was experienced as a trigger event that fostered leaders’ new understandings of what virtue is and how virtues inform behaviour, and (b) The Virtues Project training equipped leaders with language-based strategies to incorporate virtues into their leadership practices. In sum, participating leaders felt that The Virtues Project facilitated the development of their leadership by enabling them to understand and recognize the best in themselves and others (virtues) and to incorporate virtues into their leadership practices. Limitations and future research are discussed.
Asymmetric Volatility in Commodity Markets

Abstract The paper studies the return–volatility relationship in a range of commodities. We develop a commodity price model and show that the volatility of price changes can be positively or negatively related to demand shocks. An “inverse leverage effect”—the volatility is higher following positive price shocks—is found in more than half of the daily spot prices. The effect is weaker in the three-month futures market, the period after mid-2000s and monthly historical volatility measures. Only crude oil exhibits a “leverage effect”—higher volatility follows a negative shock—and the reason is explored in the context of its special market structure.
Predicting Taxi and Uber Demand in Cities: Approaching the Limit of Predictability

Time series prediction has wide applications ranging from stock price prediction, product demand estimation to economic forecasting. In this article, we treat the taxi and Uber demand in each location as a time series, and reduce the taxi and Uber demand prediction problem to a time series prediction problem. We answer two key questions in this area. First, time series have different temporal regularity. Some are easy to be predicted and others are not. Given a predictive algorithm such as LSTM (deep learning) or ARIMA (time series), what is the maximum prediction accuracy that it can reach if it captures all the temporal patterns of that time series? Second, given the maximum predictability, which algorithm could approach the upper bound in terms of prediction accuracy? To answer these two question, we use temporal-correlated entropy to measure the time series regularity and obtain the maximum predictability. Testing with 14 million data samples, we find that the deep learning algorithm is not always the best algorithm for prediction. When the time series has a high predictability a simple Markov prediction algorithm (training time 0.5s) could outperform a deep learning algorithm (training time 6 hours). The predictability can help determine which predictor to use in terms of the accuracy and computational costs. We also find that the Uber demand is easier to be predicted compared the taxi demand due to different cruising strategies as the former is demand driven with higher temporal regularity.
Effectiveness of Budgeting and Budgetary Control on the Performance of Ado-Ekiti Local Government in Nigeria

This study examinedthe effectiveness of budgeting and budgetary control on the performance of Ado-Ekiti Local Government in Nigeria.In this study, we adopted a descriptive research design with datagathered through questionnaire administered to some selected respondents. The non-parametric tool of chi square was employed to analysethe data. The hypotheses were tested and analyzed on a 5% level of significance and it was revealed that budgeting is a usefultool that guides local government to evaluate whether their goals and objectives are actualized. Considering the changing environment in which governments now operate and serve, it can be concluded that budget, which is a continuous management activity, should adaptto changes in the dynamic business environment. Keywords : Budgeting, Budgetary Control, Local Government, Ado-Ekiti, Performance DOI : 10.7176/RJFA/10-8-06 Publication date : April 30 th 2019
Geoaccumulation and Ecological Risk Indexes in Papaya Cultivation Due to the Presence of Trace Metals

The aim of this research was to evaluate the impact of heavy metals on Maradol papaya cultivation soil, through the geoaccumulation index (Igeo) and the ecological potential risk index (RI). Soil samples from 15 locations in the Cotaxtla municipality of Veracruz, Mexico were tested for pH, soil texture, and concentrations of lead (Pb), chromium (Cr), cadmium (Cd), zinc (Zn), copper (Cu), and organic matter (MO). The pH varied between values of 5.5 ± 0.10 and 7.7 ± 0.22, while the MO varied from 1.57% ± 0.97% to 13.1% ± 1.342%. The type of soil texture represented 48% sandy loam, 40% loam, 8% clay loam, and 4% silt-loam. For heavy metals, average levels were found in the following order Cr (0.695 ± 0.018) > Zn (0.615 ± 0.016) > Pb (0.323 ± 0.012) > Cu (0.983 ± 0.011) > Cd (0.196 ± 0.011) mg kg−1. The Igeo values from 96% of the analyzed sampling points were below zero and were considered uncontaminated. The other 4% of samples, from the Potrerillo1 (PT) site, had Igeo values of 1.13, where the highest concentration of Cd was found, which indicates moderate contamination levels. The RI index at the PT site was in the category of moderate contamination, and the rest of the points correspond to the category of low pollution.
The role of video-assisted feedback sessions in resident teaching: A pre-post intervention

This article was migrated. The article was marked as recommended. Purpose: Despite providing a large component of teaching to trainees, internal medicine residents receive little feedback on their teaching ability. Methods: This was a single-center, mixed methods study of 19 senior internal medicine residents in Canada. Classroom-based teaching sessions delivered by the participants were individually video recorded. The individual recording was then watched by the participant and by two feedback facilitators, who then met for face-to-face feedback. Participants completed a self-reflective exercise after this intervention. Audience members of the recorded session and a post-feedback teaching session completed an evaluation form. Scores from the evaluation forms from each phase were analyzed with the Wilcoxon Signed-Rank Test. Inductive coding was performed for qualitative data from the feedback sessions and reflective exercises. Results: 19 residents participated. There was no statistical difference in the evaluation form scores between the pre-intervention and post-intervention teaching sessions. Mean scores varied from 4.6 to 5.0 out of 5.0 on combined pre-and post-intervention evaluations. 89% of participants found viewing their recorded session useful. 94% of residents stated the intervention was worth continuing. Common themes of feedback and self-evaluation included “time-management,” “organization,” “communication,” and “environment. ” Conclusion: Video-assisted feedback of teaching improved self-perception of a resident’s teaching ability.
The physiopathology and treatment of in-stent restenosis

appropriate alternative to surgical revascularization in the management of coronary artery disease. Despite new medications and techniques, in-stent restenosis still remains an unresolved problem. Brachytherapy and drugeluting stents are current therapeutic options to reduce instent restenosis and decrease the probability of its occurrence, respectively. This article revisits the pathophysiology and current therapeutic modalities of in-stent restenosis.
UMAP does not preserve global structure any better than t-SNE when using the same initialization

One of the most ubiquitous analysis tools employed in single-cell transcriptomics and cytometry is t-distributed stochastic neighbor embedding (t-SNE) [1], used to visualize individual cells as points on a 2D scatter plot such that similar cells are positioned close together. Recently, a related algorithm, called uniform manifold approximation and projection (UMAP) [2] has attracted substantial attention in the single-cell community. In Nature Biotechnology, Becht et al. [3] argued that UMAP is preferable to t-SNE because it better preserves the global structure of the data and is more consistent across runs. Here we show that this alleged superiority of UMAP can be entirely attributed to different choices of initialization in the implementations used by Becht et al.: t-SNE implementations by default used random initialization, while the UMAP implementation used a technique called Laplacian eigenmaps [4] to initialize the embedding. We show that UMAP with random initialization preserves global structure as poorly as t-SNE with random initialization, while t-SNE with informative initialization performs as well as UMAP with informative initialization. Hence, contrary to the claims of Becht et al., their experiments do not demonstrate any advantage of the UMAP algorithm per se, but rather warn against using random initialization.
Renewable Energy for Robots and Robots for Renewable Energy – A Review

SUMMARY Fossil fuel sources are well suited to fulfill the energy needs of human beings. Unfortunately, there are some limitations and disadvantages pertaining to fossil fuels, some of which are drastic. The main issues are: firstly, there is a finite supply of these fuels, eventually this supply will be exhausted; secondly, burning fossil fuels contributes to global warming, leading to disastrous consequences for the environment and the health of humans. Switching to renewable energy sources is the viable solution to the aforementioned issues. Robots bring numerous benefits in a wide variety of applications. Introducing robots to production environments and other applications results in a remarkable improvement in terms of productivity and efficiency. In this paper, the integration between robots and renewable energy sources is discussed. In other words, two main points are investigated: (1) how can renewable energy be a viable source of energy for robots and (2) how can the renewable energy industry benefit from utilizing robots in the execution of renewable energy-related tasks. Some of the recent developments concerning the integration between robots and renewable energy are reviewed. In addition, more opportunities and expected advancements are also discussed.
New Conceptions of Sufficient Home Size in High-Income Countries: Are We Approaching a Sustainable Consumption Transition?

ABSTRACT Housing plays a significant role in impelling demand for natural resources and driving economic growth in high-income countries. Public policies, commercial prerogatives, and other inducements have encouraged construction and occupancy of ever-larger homes and this pattern has persisted in the face of decreasing household size, declining fertility, ageing populations, and increasing complexity of domestic relationships. This situation has created a perverse mismatch between available housing stocks and residential requirements. Additionally, imperatives to curtail greenhouse-gas emissions and to hasten progress on the United Nations 2030 Agenda demand new planning priorities. Building on the sufficiency turn in the field of sustainable consumption, this paper first formulates parameters for estimating an environmentally tenable and globally equitable amount of per person living area. It then highlights five emblematic cases of “space-efficient” housing. While acknowledging that prevalent spatial norms are evolving, the conclusion discusses the profound challenges of achieving a successful sustainable consumption transition.