Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors influencing delay in presentation for acute stroke in an emergency department in Milan, Italy

Background and aims: Early treatment is critical for successful intervention in acute stroke. The aim of this study was to describe delays in presentation to hospital and in the emergency department (ED) management of patients with acute stroke and to identify factors influencing these delays in an Italian urban hospital. Methods: The present series includes all patients presenting with acute stroke, in whom arrival delay was ascertainable. To describe delays into the ED, the triage–visit delay, visit–computed tomography (CT) delay and visit–CT report delay were registered. Type of stroke, severity of stroke assessed using the modified National Institute of Health Stroke Scale (mNIHSS) scale, level of consciousness, history of previous stroke or previous hospital admission, use of the emergency medical service (EMS), onset of stroke during day or night and admission during working or non-working day were registered for every patient. Univariate and multivariate analysis were performed to evaluate factors influencing early arrival. Results: Over a one-year period 537 patients with acute stroke were evaluated; 375 patients in whom arrival delay was ascertainable were included in the study. Median arrival delay was 5.4 h (interquartile range (IQR) 2.7–11.6); 104 patients (28%) arrived within 3 h and 198 (53%) within 6 h. Triage–visit delay was 0.3 h (IQR 0.2–0.7), visit–CT scan delay was 1.2 h (IQR 0.8–1.9), visit–CT report delay was 2.7 h (IQR 1.7–4.5). Triage–visit delay and visit–CT delay were shorter for patients presenting within 3 h. The type of stroke was ischaemic in 240 (64%), haemorrhagic in 61 (16%) and transient ischaemic attack in 74 (20%). The median basal mNIHSS score was 5 (IQR 3–10); 64 patients (17%) had an altered level of consciousness, 103 (27%) had had a previous stroke, 223 (59%) had had a previous hospital admittance. In this series 214 patients (57%) arrived with the EMS, 323 (86%) presented with symptoms during the day, 261 (70%) were admitted during working days. Univariate analysis showed a significantly shorter arrival delay in patients calling the EMS (median 4.2 vs 7.2 h; p<0.001) and in patients with a higher basal mNIHSS score (Spearman ρ = −0.204; p<0.001) or altered level of consciousness (normal 5.8 h, not alert but arousable 3.8, not alert but arousable with strong stimulation 2.5, totally unresponsive 6.0; p = 0.005). Multivariate analysis showed that use of the EMS and higher basal mNIHSS score were independent variables associated with a shorter arrival delay. Conclusion: A substantial proportion of patients does not arrive at the ED in a suitable time for reperfusion therapy. Patients using the EMS have a shorter arrival delay. Approximately half of the patients with stroke are sufficiently aware of the urgency of this clinical condition to activate the emergency telephone system.
Reduction of Mental Stress with Lavender Odorant

The effect of the lavender odorant on a Japanese version of Cox and Mackay's stress/arousal adjective checklist for three groups was studied. One group of 14 was placed into a (2- x 2- x 3-m) sound-protected room for 20 min. without the presentation of an odor, an analogous group of 15 received the odor oil, and one group of 13 received a nonstressful condition. Analysis suggested that lavender odorants were associated with reduced mental stress and increased arousal rate.
Differential lesion patterns in CADASIL and sporadic subcortical arteriosclerotic encephalopathy: MR imaging study with statistical parametric group comparison.

PURPOSE To differentiate lesion patterns in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) from those in patients with sporadic subcortical arteriosclerotic encephalopathy (sSAE). MATERIALS AND METHODS Magnetic resonance (MR; T2-weighted and fluid-attenuated inversion-recovery) images obtained in 28 patients with CADASIL were compared with images obtained in 24 patients with sSAE by using an automated pixel-based group comparison with statistical parametric mapping and regional semiquantitative rating. RESULTS Visual rating showed higher lesion scores for CADASIL in the temporal and temporopolar white matter (WM). Statistical parametric mapping group analysis independently revealed more extensive bilateral involvement of the anterior temporal and superior frontal WM in CADASIL. There were bilateral signal intensity reductions within the dentate nucleus, deep cerebellar WM, crus cerebri, and thalamus. Lesions extended remarkably more often into arcuate fibers in the temporopolar and paramedian superior frontal lobes in CADASIL. Linear discriminant analysis was used to classify 96% (50 of 52) of the cases correctly, with temporopolar WM and arcuate fiber involvement contributing most to the discrimination function. CONCLUSION The presented MR imaging criteria are useful in the diagnostic work-up in patients with leukoencephalopathy and help to differentiate CADASIL from sSAE. The observed pattern of vulnerability in CADASIL suggests future directions for research in the pathophysiology of this disorder. In addition, the study demonstrates the potential of automated image analysis to explore MR imaging lesion patterns.
Maxillofacial features and systemic malformations in expanded spectrum Hemifacial Microsomia

Hemifacial microsomia (HFM) is a rare, multisystemic congenital disease with estimated frequency of 1/26370 births in Europe. Most cases are sporadic and caused by unilateral abnormal morphogenesis of the first and second pharyngeal arches. The aim of this study is to define the types and frequency of maxillofacial and systemic malformations in HFM patients. This is a case series study of patients with HFM evaluated at a single institution. Data were acquired through history, physical examination, photographs, diagnostic radiology, and laboratory and analyzed by the FileMakerPro database on 95 patients (54F; 41M) of which 89 met the inclusion criteria. Mandibular hypoplasia was observed in 86 patients with right‐side preponderance (50). One patient had bilateral mandibular hypoplasia. Seventy‐four had external ear anomalies (anotia or microtia). Eleven had bilateral malformed ears. Hearing impairment, associated with stenosis or atresia of the external ear canal, was found in 69 patients (eight with bilateral canal defects). Ocular anomalies were seen in 41 (23 with dermoid cysts) and 39 had orbital malformations. Facial nerve paralysis was observed in 38 patients. Cleft lip/palate (10), preauricular tags (55), and macrostomia (41) were also described. A total of 73/86 had systemic malformations, mainly vertebral (40), genitourinary (25), and cardiovascular (28). Sixteen had cerebral anomalies (four with intellectual disability). All patients suspected of HFM should undergo a complete systematic clinical and imaging investigation to define the full scope of anomalies. Since the disease is rare and complex, affected patients should be monitored by specialized multidisciplinary team centers.
Antimicrobial activity of Pycnogenol®

Pycnogenol®, a standardized extract of Pinus pinaster bark, was tested for its antimicrobial activity against 23 different pathogenic prokaryotic (gram‐positive and gram‐negative) and eukaryotic (yeast and fungi) microorganisms. Pycnogenol® inhibited the growth of all the tested microorganisms in minimum concentrations ranging from 20 to 250 µg/mL. Thus, Pycnogenol® in concentrations as low as 0.025% could counteract the growth of all the strains investigated in our study. These results conform with clinical oral health care studies describing the prevention of plaque formation and the clearance of candidiasis by Pycnogenol®. Copyright © 2005 John Wiley & Sons, Ltd.
Teacher–child relationships as a developmental issue

Teacher–child relationships may be a developmental issue in its own right, instead of an aspect of wider developmental issues such as attachment or adaptation to school. This paper discusses research findings on teacher–child relationships to argue that teacher–child relationships are important for carrying forward the experiences represented in the attachment behavioral system, although it is not clear whether teacher–child relationships themselves add to the attachment behavioral system or to the sociability behavioral system. The research demonstrates that attachment theory offers a useful template for understanding the role of teacher–child relationships in development. Listing teacher–child relationships among main developmental issues for today's children puts the spotlight on avenues for improving teacher–child relationships.
Characterization of alcohol dehydrogenase genes of derepressible wild-type Alcaligenes eutrophus H16 and constitutive mutants

The nucleotide sequence of the gene that encodes the fermentative, derepressible alcohol dehydrogenase (ADH) in Alcaligenes eutrophus H16 and of adjacent regions was recently determined. Two potential -10 regions resembling the Escherichia coli sigma 70 consensus sequence were identified 77 and 93 nucleotides upstream of the structural gene. By determination of the 5' mRNA terminus of the wild-type adh gene, the proximal -10 region was identified as responsible for adh expression under derepressive conditions. Transcription started seven nucleotides downstream of this region, at position 388. Sequence analysis of seven mutants expressing the adh gene under aerobic conditions revealed mutations in one or the other potential -10 region. In all seven strains, the mutations restored the invariant T of the E. coli promoter consensus sequence. Mutants altered in the proximal -10 region transcribed the adh gene under aerobic conditions with the same 5' mRNA terminus as in the wild type; gene expression was impaired very little under aerobic conditions. Mutants altered in the distal -10 region also transcribed the adh gene aerobically but were still partially derepressible. The 5' mRNA terminus was seven nucleotides downstream of the distal -10 region, at position 372. When these mutants were cultivated under conditions of restricted oxygen supply, the adh gene was transcribed from both -10 regions, resulting in the synthesis of two mRNA species with different 5' termini.
Radio Frequency Identification and Motion-sensitive Video Efficiently Automate Recording of Unrewarded Choice Behavior by Bumblebees

We present two methods for observing bumblebee choice behavior in an enclosed testing space. The first method consists of Radio Frequency Identification (RFID) readers built into artificial flowers that display various visual cues, and RFID tags (i.e., passive transponders) glued to the thorax of bumblebee workers. The novelty in our implementation is that RFID readers are built directly into artificial flowers that are capable of displaying several distinct visual properties such as color, pattern type, spatial frequency (i.e., “busyness” of the pattern), and symmetry (spatial frequency and symmetry were not manipulated in this experiment). Additionally, these visual displays in conjunction with the automated systems are capable of recording unrewarded and untrained choice behavior. The second method consists of recording choice behavior at artificial flowers using motion-sensitive high-definition camcorders. Bumblebees have number tags glued to their thoraces for unique identification. The advantage in this implementation over RFID is that in addition to observing landing behavior, alternate measures of preference such as hovering and antennation may also be observed. Both automation methods increase experimental control, and internal validity by allowing larger scale studies that take into account individual differences. External validity is also improved because bees can freely enter and exit the testing environment without constraints such as the availability of a research assistant on-site. Compared to human observation in real time, the automated methods are more cost-effective and possibly less error-prone.
Sustainable Supply Chain Management Implementation–Enablers and Barriers in the Textile Industry

The distinct definition of accordance in the perceived barriers and enablers for sustainable supply chain management (SSCM) policy implementation has been the subject of various research studies, but a distinct focus on the textile sector has been the object of limited previous attention. However, it has been found that it affects the approach to developments in company approaches to sustainable supply chain management within that industry. This article presents the results of an in-depth comparative case study analysis, drawing on 23 interviews with managers of 10 companies from the textile industry. The analysis demonstrates that specific modes of collaboration can both enable an effective SSCM and diminish barriers for policy implementation. The width and depth varies between a collaborative management approach for an effective internal SSCM versus industry collaboration and buyer supplier collaboration to address external barriers and enablers.
How Implicit Self-Theorist Moderate the Influence of Doctors Communication Skill on Patient Satisfaction: A Case Study in Hospital Industry in Indonesia

An increase the number of visits patients seeking a treatment are thing that need to be concerned to improve hospital revenue. The hospital should be able to create patient satisfaction by improving its service quality. One of the things that are part of service quality is doctors’ communication skill on patients. A good communication skill of the doctors will create patient satisfaction. It has been proven in previous researches that said patients showed significantly increase satisfaction to individual consultations, with the greatest increase in satisfaction on doctor communication skills. However, not all patients have the same reaction to communication style of the doctors. So far, there is no researches that includes about doctor communication skills that influenced by the nature of the individual itself, Hence in this research, the researcher wants to include the influence of individual nature on communication skills and patient satisfaction, in which implicit self-theorist will act as moderate variable between the communication skills on patient satisfaction that was not found in previous researches. This study is conducted to 120 respondents of men and women aged 18-70 years who seek outpatient treatment at a hospital in South Jakarta, Indonesia by using a questionnaire. Data analysis method used in this study is General Linear Model (GLM) method. The results of this research is found that the doctor communication skills improve patient satisfaction, especially for a group of individual entity, a group of patients who have a perception of high communication skills have greater satisfaction than the group of patients with the perception of low communication skills and specifically to the group of patients with the perception of low communication skills, the individual incremental group are more satisfied than the individual entity group. This research found that implicit self-theorist moderate communication skills on patient’ satisfaction.
Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury.

BACKGROUND AND OBJECTIVES Several novel urinary biomarkers have shown promise in the early detection and diagnostic evaluation of acute kidney injury (AKI). Clinicians have limited tools to determine which patients will progress to more severe forms of AKI at the time of serum creatinine increase. The diagnostic and prognostic utility of novel and traditional AKI biomarkers was evaluated during a prospective study of 123 adults undergoing cardiac surgery. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Urinary neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CyC), kidney injury molecule-1 (KIM-1), hepatocyte growth factor (HGF), π-glutathione-S-transferase (π-GST), α-GST, and fractional excretions of sodium and urea were all measured at preoperative baseline, postoperatively, and at the time of the initial clinical diagnosis of AKI. Receiver operator characteristic curves were generated and the areas under the curve (AUCs) were compared. RESULTS Forty-six (37.4%) subjects developed AKI Network stage 1 AKI; 9 (7.3%) of whom progressed to stage 3. Preoperative KIM-1 and α-GST were able to predict the future development of stage 1 and stage 3 AKI. Urine CyC at intensive care unit (ICU) arrival best detected early stage 1 AKI (AUC = 0.70, P < 0.001); the 6-hour ICU NGAL (AUC = 0.88; P < 0.001) best detected early stage 3 AKI. π-GST best predicted the progression to stage 3 AKI at the time of creatinine increase (AUC = 0.86; P = 0.002). CONCLUSION Urinary biomarkers may improve the ability to detect early AKI and determine the clinical prognosis of AKI at the time of diagnosis.
Emotional intelligence is associated with connectivity within and between resting state networks

Abstract Emotional intelligence (EI) is defined as an individual’s capacity to accurately perceive, understand, reason about, and regulate emotions, and to apply that information to facilitate thought and achieve goals. Although EI plays an important role in mental health and success in academic, professional and social realms, the neurocircuitry underlying this capacity remains poorly characterized, and no study to date has yet examined the relationship between EI and intrinsic neural network function. Here, in a sample of 54 healthy individuals (28 women, 26 men), we apply independent components analysis (ICA) with dual regression to functional magnetic resonance imaging (fMRI) data acquired while subjects were resting in the scanner to investigate brain circuits (intrinsic resting state networks) whose activity is associated with greater self-reported (i.e. Trait) and objectively measured (i.e. Ability) EI. We show that higher Ability EI, but not Trait EI, is associated with stronger negatively correlated spontaneous fMRI signals between the basal ganglia/limbic network (BGN) and posterior default mode network (DMN), and regions involved in emotional processing and regulation. Importantly, these findings suggest that the functional connectivity within and between intrinsic networks associated with mentation, affective regulation, emotion processing, and reward are strongly related to ability EI.
Analysis of aromatic acids by nonaqueous capillary electrophoresis with ionic‐liquid electrolytes

The separation of six kinds of aromatic acids by CZE with 1‐ethyl‐3‐methylimidazolium chloride (EMIMCl) and 1‐ethyl‐3‐methylimidazolium hydrogen sulfate (EMIMHSO4), two kinds of ionic liquids (ILs) as background electrolytes, and acetonitrile as solvent were investigated. The six kinds of aromatic acids can be separated under positive voltage with low IL concentration with either of the two ILs and separation with EMIMHSO4 is better in consideration of peak shapes and separation efficiency. But the migration order is different when the IL is different. Under negative voltage with high IL concentration, the six analytes can be separated with EMIMCl as background electrolytes and the migration order of the analytes is opposite to those with low concentration of EMIMCl as background electrolyte. The separations are based on the combination effects of heteroconjugation between the anions and cations in the ILs and the analytes, of which the heteroconjugation between the anions in the ILs and the analytes plays a dominant role. The heteroconjugation between the anions of the ILs and analytes is proton sensitive and only a very small amount of proticsolvents added into the electrolyte solution can harm the separation. When EMIMCl concentration is high, the heteroconjugation between the IL anions and the proton in the analytes make the effective mobility of the analytes much higher than the EOF and their migration direction reversed. Finally, the six aromatic acids in water samples were analyzed by nonaqueous CE with low concentration of EMIMHSO4 as background electrolytes with satisfactory results.
Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells

Abstract Lymphopenia and increasing viral load in the first 10 days of severe acute respiratory syndrome (SARS) suggested immune evasion by SARS-coronavirus (CoV). In this study, we focused on dendritic cells (DCs) which play important roles in linking the innate and adaptive immunity. SARS-CoV was shown to infect both immature and mature human monocyte-derived DCs by electron microscopy and immunofluorescence. The detection of negative strands of SARS-CoV RNA in DCs suggested viral replication. However, no increase in viral RNA was observed. Using cytopathic assays, no increase in virus titer was detected in infected DCs and cell-culture supernatant, confirming that virus replication was incomplete. No induction of apoptosis or maturation was detected in SARS-CoV–infected DCs. The SARS-CoV–infected DCs showed low expression of antiviral cytokines (interferon α [IFN-α], IFN-β, IFN-γ, and interleukin 12p40 [IL-12p40]), moderate up-regulation of proinflammatory cytokines (tumor necrosis factor α [TNF-α] and IL-6) but significant up-regulation of inflammatory chemokines (macrophage inflammatory protein 1α [MIP-1α], regulated on activation normal T cell expressed and secreted [RANTES]), interferon-inducible protein of 10 kDa [IP-10], and monocyte chemoattractant protein 1 [MCP-1]). The lack of antiviral cytokine response against a background of intense chemokine up-regulation could represent a mechanism of immune evasion by SARS-CoV.
A comparative study of different MPPT techniques using different dc-dc converters in a standalone PV system

This paper describes the application of MPPT to solar PV system and presents a comparative study between different mppt algorithms using different dc-dc converters. The MPPT algorithm is very effective electronic means to operate the pv array at its MPP regardless of changing environmental conditions. The working methodology of direct MPPT control is illustrated in detail . This paper presents the comparative study of two dc-dc converters in terms of output current and voltage ripple. Similarly the efficiency of system with two different algorithm is studied and presented under varying uniform and non-uniform irradiation conditions. Matlab R2014a version used for simulation studies. The effectiveness of the MPPT in standalone PV system is represented through simulation results in this work.