Miracle-dz/UniFAR-FTUs huggingface dataset:
CT angiography based Study of Variations in Coeliac Trunk and its surgical implications .

Objective: The aim of this study was to detect and describe the existence and incidence of anatomical variations of the coeliac trunk by Using imaging technique. Materials and Methods: 80 patients visited the, radiology department of S.M.S.MEDICAL college jaipur . To cover the whole abdominal aorta in each patient, spiral CT angiography scan will be made and thin slices (0.6 mm) axial images will be obtained, Both sagittal and coronal images will be reconstructed. Results: We found that 77.5% of patients presented a classic anatomy of the coeliac trunk, Using this imaging technique, we found the existence of variations of these abdominal blood vessels in 22.5% of patients. Conclusion: The arterial variations should not be ignored and with an accurate knowledge on the anatomical variations, many operative and post operative complications can be avoided. The knowledge on the CT variations would enable the radiologists in protecting the important vessels prior to transcatheter therapies, and also in preventing inadvertent injuries.
The Contribution of Case Mix, Skill Mix and Care Processes to the Outcomes of Community Hospitals: A Population-Based Observational Study

Background: New organizational models to face the unmet needs of frail patients are needed. Community hospitals (CHs) could foster integration between acute and primary care. The aim of this study was to investigate which characteristics of the patients and which care processes affect clinical outcomes, in order to identify who could benefit the most from CH care. Methods: This study included all patients aged 65 and older and discharged in 2017 from the 16 CHs of Emilia-Romagna, Italy. Data sources were the regional CH informative system and hospital discharge records. CH skill mix and processes of care were collected with a survey. The study outcome was variation of the Barthel index (BI). We performed a 2-level random-intercept logistic regression analysis, and used the variance partition coefficient (VPC) to quantify the proportion of BI improvement that lay at CH level. Results: Of the 13 CHs, 8 had a general practitioner medical support model, and 6 had >12 nurses working hours/week/bed. Overall, 53% of the patients had a BI improvement of 10 or more. The patient case mix explained a portion of variability across CHs. Skill mix and processes of care were not associated with BI change. Conclusions: Patients characteristics explained part of between-CH variation in BI improvement. Professional skill mix and processes of care, albeit fundamental to achieve appropriate care and respond to the unmet needs of the frail elderly, did not account for differences in CH-specific outcomes.
Muscle Cachexia: Current Concepts of Intracellular Mechanisms and Molecular Regulation

ObjectiveTo review present knowledge of intracellular mechanisms and molecular regulation of muscle cachexia. Summary Background DataMuscle cachexia, mainly reflecting degradation of myofibrillar proteins, is an important clinical feature in patients with severe injury, sepsis, and cancer. The catabolic response in skeletal muscle may result in muscle wasting and weakness, delaying or preventing ambulation and rehabilitation in these patients and increasing the risk for pulmonary complications. ResultsMuscle cachexia, induced by severe injury, sepsis, and cancer, is associated with increased gene expression and activity of the calcium/calpain- and ubiquitin/proteasome-proteolytic pathways. Calcium/calpain-regulated release of myofilaments from the sarcomere is an early, and perhaps rate-limiting, component of the catabolic response in muscle. Released myofilaments are ubiquitinated in the N-end rule pathway, regulated by the ubiquitin-conjugating enzyme E214k and the ubiquitin ligase E3&agr;, and degraded by the 26S proteasome. ConclusionsAn understanding of the mechanisms regulating muscle protein breakdown is important for the development of therapeutic strategies aimed at treating or preventing muscle cachexia in patients with severe injury, sepsis, cancer, and perhaps other catabolic conditions as well.
The active site of the DNA repair endonuclease XPF–ERCC1 forms a highly conserved nuclease motif

XPF–ERCC1 is a structure‐specific endonuclease involved in nucleotide excision repair, interstrand crosslink repair and homologous recombination. So far, it has not been shown experimentally which subunit of the heterodimer harbors the nuclease activity and which amino acids contribute to catalysis. We used an affinity cleavage assay and located the active site to amino acids 670–740 of XPF. Point mutations generated in this region were analyzed for their role in nuclease activity, metal coordination and DNA binding. Several acidic and basic residues turned out to be required for nuclease activity, but not DNA binding. The separation of substrate binding and catalysis by XPF–ERCC1 will be invaluable in studying the role of this protein in various DNA repair processes. Alignment of the active site region of XPF with proteins belonging to the Mus81 family and a putative archaeal RNA helicase family reveals that seven of the residues of XPF involved in nuclease activity are absolutely conserved in the three protein families, indicating that they share a common nuclease motif.
Platelets, Platelet‐Derived Growth Factor, Growth Control, and their Interactions with the Vascular Wall

The response-to-injury hypothesis of atherosclerosis describes how risk factors associated with atherogenesis may alter endothelial function, creating opportunities for endothelial cell separation and interactions with blood monocyte/macrophages and platelets that result in the intimal proliferative smooth-muscle lesions of atherosclerosis. Growth factors derived from platelets (platelet-derived growth factor) and macrophages (macrophage-derived growth factor) are described and their possible role in atherogenesis is presented. Possible approaches for the prevention of atherosclerosis include the development of means of interfering with the activity of these growth factors.
Physicochemical, Biochemical and Instrumental Attributes and Consumer Acceptability of Dry-Fermented Sausages Elaborated with Combined Partial Substitutions of Sodium Chloride and Pork Backfat

We performed 6 fabrications of dry-fermented sausages to investigate, at laboratory scale, the effects of combined partial substitutions of sodium chloride by potassium chloride and pork backfat by sunflower oil on key physical-chemical and biochemical parameters, instrumental colour and texture measurements, and the consumer acceptability of the end-products. Regarding the physical-chemical parameters, statistical analysis of results showed that final product weight loss was impacted by fat content and use of sunflower oil; final mean water activity value was only affected by salt level; and animal fat content impacted pH values, only at the end of drying. Regarding the biochemical parameters investigated, we statistically found a marked impact of partial substitution of NaCl by KCl on the proteolysis evolution, of fat level and sodium content on the end-product lipolysis, and finally, a significant effect of animal fat level and incorporation of sunflower oil on both protein and lipid oxidations. However, the new product formulations combining salt and fat substitutions lead to globally acceptable water loss and water activity values and similar rates of proteolysis, lipolysis and lipid oxidation, but less protein oxidation. From a practical point of view, the results clearly showed that sodium and animal fat contents in dryfermented sausages can be drastically reduced with no too marked adverse effect on colour, final textural properties or consumer acceptability. On the basis of these laboratory results, new healthier dry-fermented products can be manufactured by an industrial company in the near future.
Total Absorption of Electromagnetic Waves in Ultimately Thin Layers

We consider single-layer arrays of electrically small lossy particles that completely absorb electromagnetic waves at normal incidence. Required conditions for electromagnetic properties of bi-anisotropic particles have been identified in the most general case of uniaxial reciprocal and nonreciprocal particles. We consider the design possibilities offered by the particles of all four fundamental classes of bi-anisotropic inclusions: reciprocal chiral and omega particles and nonreciprocal Tellegen and moving particles. We also study the reflection/transmission properties of asymmetric structures with different properties when illuminated from the opposite sides of the sheet. It has been found that it is possible to realize single-layer grids which exhibit the total absorption property when illuminated from one side but are totally transparent when illuminated from the other side (an ultimately thin isolator). Other possible properties are co-polarized or twist polarized reflection from the side opposite to the absorbing one. Finally, we discuss possible approaches to practical realization of particles with the properties required for single-layer perfect absorbers and other proposed devices.
Immediate reduction of white blood cell count after tocilizumab administration was observed in some cases

It has been reported that tocilizumab (TCZ), a drug used to treat rheumatoid arthritis (RA) [1-3], is well tolerated by patients. One important aspect of TCZ drug therapy is the risk of infection [4]. The guidelines of the Japan College of Rheumatology (JCR) of Biologics for the treatment of patients with RA state that the peripheral white blood cell (WBC) count should be [4,000/ll to prevent any opportunistic infection. In particular, the early symptoms of pneumonia may be masked after the administration of TCZ [4]. Therefore, it is necessary to assess the WBC counts before and after the TCZ administration. In this study, the complete blood cell (CBC) count was measured immediately before and after TCZ administration, and the effect of TCZ administration on the WBC count was assessed.
Optimal operation of thermal generating units and smart houses considering transmission constraints

Due to the deregulation and liberalization in power market, thermal unit commitment program is researched and developed in the world wide. On the other hand, fuel exhaustion and global warming is increasing, therefore, the renewable power plant is introduced to the power system. The generated power of the large capacity renewable energy plant reads to the violated transmission constraint in thermal unit commitment program, therefore, the transmission constraint should be considered. This paper focuses on the optimal operation of the thermal units incorporated controllable loads such as electrical vehicle (EV) and heat pump (HP) considering the transmission constraints. The proposed method is compared with the power flow in thermal units operation without controllable loads and the optimal operation without the transmission constraints. Simulation results show the validation of the proposed method and validate the performance and effectiveness of the proposed algorithm of thermal units in power supply side and the controllable loads in demand side.
Microbiologic Characteristics of invasive Streptococcus pyogenes Infections in 1 North and South India 2 3 Running title : Invasive S . pyogenes infections in India

Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden; Helmholtz Centre 10 for Infection Research, Braunschweig, Germany; School of Public Health, Postgraduate Institute 11 of Medical Education and Research, Chandigarh, India; 4 Dept. of Community Health, Christian 12 Medical College, Vellore, India; Dept. of Microbiology Christian Medical College, Vellore, 13 India; Department of Transplant Immunology and Immunogenetics, All Indian Institute of 14
Colonization is a crucial factor in oral candidiasis.

Dr. Cannon is Senior Lecturer in Molecular Microbiology in the Department of Oral Sciences and Orthodontics, University of Otago, Dunedin, New Zealand. Dr. Chaffin is Professor of Microbiology in the Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas. Direct correspondence and requests for reprints to Dr. Richard D. Cannon, Department of Oral Sciences and Orthodontics, University of Otago, P.O. Box 647, Dunedin 9001, New Zealand; +64 3 479 7081 phone; +64 3 479 0673 fax; richard.cannon@stonebow.otago. ac.nz.
Research on semantic based emergency command system of Typhoon prevention

As independent storage in existed Typhoon emergency command information system, prediction schema and cases are lack of semantic relations and weak in readability and relevance, which leads to unsupported intelligent retrieval and reuse, is not conducive to intelligent decision support. We applied semantic technologies through the semantic research of prediction schema and cases in emergency command system of Typhoon, proposed and implemented typhoon prevention emergency command semantic model, then constructed and annotated typhoon prevention emergency predication scheme and its case description ontology, and designed interacted semantic retrieval and intelligent decision model, finally gives the corresponding prototype system.
A Novel Quantitative Approach for Biomechanical Performance Evaluation of a Meniscal Implant

INTRODUCTION: One of functions of the meniscus is to distribute contact forces over the articular surfaces by increasing joint contact areas [1]. It is widely accepted that total/partial loss of the meniscus increases the risk of joint degeneration. A short-term method for evaluating whether degenerative arthritis can be prevented would be to determine if peak pressure and contact area coverage of the tibialis plateau (TP) articular surface in the knee are restored at the time of implantation. Although several published works already utilized TP contact pressure measurements as an indicator for biomechanical performance of allograft menisci [2,3], there is a paucity of a quantitative method for evaluation of these parameters in situ with a single effective parameter. In the present study, we developed such a method and employed it on sheep and human cadaveric knees.
Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120

A number of linear and conformation-dependent neutralizing monoclonal antibodies (MAbs) have been mapped to the first and second variable (V1 and V2) domains of human immunodeficiency virus type 1 (HIV-1) gp120. The majority of these MAbs are as effective at neutralizing HIV-1 infectivity as MAbs to the V3 domain and the CD4 binding site. The linear MAbs bind to amino acid residues 162 to 171, and changes at residues 183/184 (PI/SG) and 191/192/193 (YSL/GSS) within the V2 domain abrogate the binding of the two conformation-dependent MAbs, 11/68b and CRA-4, respectively. Surprisingly, a change at residue 435 (Y/H or Y/S), in a region of gp120 near the CD4 binding site (M. Kowalski, J. Potz, L. Basiripour, T. Dorfman, W. C. Goh, E. Terwilliger, A. Dayton, C. Rosen, W. Haseltine, and J. Sodroski, Science 237:1351-1355, 1987; L. A. Lasky, G. M. Nakamura, D. H. Smith, C. Fennie, C. Shimasaki, E. Patzer, P. Berman, T. Gregory, and D. Capon, Cell 50:975-985, 1987; and U. Olshevsky, E. Helseth, C. Furman, J. Li, W. Haseltine, and J. Sodroski, J. Virol. 64:5701-5707, 1990), abrogated gp120 recognition by both of the conformation-dependent MAbs. However, both MAbs 11/68b and CRA-4 were able to bind to HIV-1 V1V2 chimeric fusion proteins expressing the V1V2 domains in the absence of C4, suggesting that residues in C4 are not components of the epitopes but that amino acid changes in C4 may affect the structure of the V1V2 domains. This is consistent with the ability of soluble CD4 to block 11/68b and CRA-4 binding to both native cell surface-expressed gp120 and recombinant gp120 and suggests that the binding of the neutralizing MAbs to the virus occurs prior to receptor interaction. Since the reciprocal inhibition, i.e., antibody inhibition of CD4-gp120 binding, was not observed, the mechanism of neutralization is probably not a blockade of virus-receptor interaction. Finally, we demonstrate that linear sequences from the V2 region are immunogenic in HIV-1-infected individuals, suggesting that the primary neutralizing response may be directed to both V2 and V3 epitopes.
Comparing Neanderthal and Human Genomes

The recent sequencing of substantial parts of Neanderthal DNA [“Sequencing and analysis of Neanderthal genomic DNA,” J. P. Noonan et al. , Research Article, 17 Nov. 2006, p. [1113][1]; ([1][2])] was preceded by releases of drafts of the chimpanzee and human genomes in 2005 and 2001, respectively
Involvement of calcium-activated potassium channels in the regulation of DNA synthesis in cultured Müller glial cells.

PURPOSE To determine the involvement of Ca(2+)-activated K(+) channels of big conductance (BK) and of Ca(2+) channels in the regulation of DNA synthesis in cultured guinea pig Müller cells. DNA synthesis was stimulated by elevated extracellular potassium, by serum, or by epidermal growth factor. METHODS Dissociated retinas from guinea pigs were cultured for 8 days. Just before confluence was achieved, the cultures were treated with the test substances in serum-free or serum-containing media. The rates of DNA synthesis were assessed by a quantitative bromodeoxyuridine immunoassay. The intracellular Ca(2+) concentration was measured by the fura-2 fluorescence technique. RESULTS Blocking the BK channels with tetraethylammonium or by iberiotoxin had no effect at normal extracellular K(+) (5.8 mM) but decreased the rate of DNA synthesis at higher extracellular K(+) (10 or 25 mM). Epidermal growth factor-induced DNA synthesis was decreased by block of BK channels or by application of the Ca(2+) channel blockers nimodipine and flunarizine. Application of epidermal growth factor elevated the intracellular Ca(2+) concentration of cultured Müller cells. This elevation was diminished by co-application of iberiotoxin or of flunarizine. CONCLUSIONS The activity of BK channels is necessary for elevated DNA synthesis in Müller cells when their membranes are depolarized and/or when the Ca(2+) influx into Müller cells is increased by growth factors. BK channels may contribute to the maintenance of DNA synthesis by increasing mitogen-induced increase in intracellular Ca(2+) concentration.
C6 : A Holistic Model for Decision Making in Web Services

Web services are playing a pivotal role in e-business, service intelligence, service science and information systems. This article will examine how the main players make decisions for activities in web service lifecycle (WSLC) and propose a holistic model for decision making in web services. More specifically, this article first examines main players in web services. It also reviews the existing web service lifecycles and proposes a demand-driven web service lifecycle for web service requesters. It will then examine six driving factors for web services, look at their interrelationships and propose a holistic model for decision making in web services, C, which consists of six Cs: communication, competition, coordination, collaboration, cooperation and control, taking into account the main players in web services and web service lifecycle (WSLC). The proposed approach will facilitate research and development of web services, e-services, service intelligence, service science and service computing.
A Tree Based DATA Transportation Scheme for wireless sensor networks

Approaches to transmit the collected data from cluster heads to the Sink, a novel inter-cluster data transportation scheme for wireless sensor networks-TBDTS (A Tree Based Data Transportation Scheme) is proposed. Considering the node's energy and location, TBDTS defines a weight value, and constructs an energy-efficient weight-based spanning tree passing through all cluster-heads. Moreover, this algorithm introduces a transmission range, and makes isolated nodes to connect to the network, by directly communicating with the Sink. Comparing with the existing algorithms, the simulation results show that TBDTS can decrease more transmission energy cost and achieve better transmission reliability.
The Final N-Terminal Trimming of a Subaminoterminal Proline-Containing HLA Class I-Restricted Antigenic Peptide in the Cytosol Is Mediated by Two Peptidases1

The proteasome produces MHC class I-restricted antigenic peptides carrying N-terminal extensions, which are trimmed by other peptidases in the cytosol or within the endoplasmic reticulum. In this study, we show that the N-terminal editing of an antigenic peptide with a predicted low TAP affinity can occur in the cytosol. Using proteomics, we identified two cytosolic peptidases, tripeptidyl peptidase II and puromycin-sensitive aminopeptidase, that trimmed the N-terminal extensions of the precursors produced by the proteasome, and led to a transient enrichment of the final antigenic peptide. These peptidases acted either sequentially or redundantly, depending on the extension remaining at the N terminus of the peptides released from the proteasome. Inhibition of these peptidases abolished the CTL-mediated recognition of Ag-expressing cells. Although we observed some proteolytic activity in fractions enriched in endoplasmic reticulum, it could not compensate for the loss of tripeptidyl peptidase II/puromycin-sensitive aminopeptidase activities.
Perioperative Care for the Older Outpatient Undergoing Ambulatory Surgery

As the number of ambulatory surgery procedures continues to grow in an aging global society, the implementation of evidence-based perioperative care programs for the elderly will assume increased importance. Given the recent advances in anesthesia, surgery, and monitoring technology, the ambulatory setting offers potential advantages for elderly patients undergoing elective surgery. In this review article we summarize the physiologic and pharmacologic effects of aging and their influence on anesthetic drugs, the important considerations in the preoperative evaluation of elderly outpatients with coexisting diseases, the advantages and disadvantages of different anesthetic techniques on a procedural-specific basis, and offer recommendations regarding the management of common postoperative side effects (including delirium and cognitive dysfunction, fatigue, dizziness, pain, and gastrointestinal dysfunction) after ambulatory surgery. We conclude with a discussion of future challenges related to the growth of ambulatory surgery practice in this segment of our surgical population. When information specifically for the elderly population was not available in the peer-reviewed literature, we drew from relevant information in other ambulatory surgery populations.