Miracle-dz/UniFAR-FTUs huggingface dataset:
Serine phosphorylation regulates the P-type potassium pump KdpFABC

KdpFABC is an ATP-dependent K+ pump that ensures bacterial survival in K+-deficient environments. Whereas transcriptional activation of kdpFABC expression is well studied, a mechanism for down regulation when K+ levels are restored has not been described. Here we show that KdpFABC is inhibited when cells return to a K+-rich environment. The mechanism of inhibition involves phosphorylation of Ser162 on KdpB, which can be reversed in vitro by treatment with serine phosphatase. Mutating Ser162 to Alanine produces constitutive activity, whereas the phosphomimetic Ser162Asp mutation inactivates the pump. Analyses of the transport cycle show that serine phosphorylation uncouples the pump and blocks the cycle after formation of the catalytic aspartyl phosphate intermediate (E1∼P). Molecular dynamics simulations show that serine phosphorylation has allosteric effects that potentially explain the uncoupling. This regulatory mechanism, unique amongst P-type pumps, furthers our understanding of how bacteria control potassium homeostasis to maintain cell volume and osmotic potential.
Incidence d'implantation de pacemaker post TAVI des patients porteurs de bloc de branche droit complet

Introduction : Le TAVI (transcatheter aortic valve implantation) est une technique de reference pour les retrecissements aortiques serres a haut risque ou risque intermediaire chirurgical. Le bloc de branche droit complet (BBDc) est un facteur predictif du risque de trouble conductif de haut grade mais son incidence n’est pas clairement connue et sa prise en charge varie en fonction des centres. Objectif : Comparer l’incidence d’implantation de pacemaker et de mortalite a 1 an des patients porteurs d’un BBDc en post TAVI par rapport aux groupes non BBDc. Methode : Etude retrospective monocentrique incluant les patients ayant beneficie d’un TAVI COREVALVE ou SAPIENS de janvier 2010 a decembre 2017 au CHU de Clermont-Ferrand. Les patients avec pacemakers pre TAVI ont ete exclus. Les caracteristiques cliniques, procedurales, electrocardiographiques et echocardiographiques ont ete analysees afin de comparer l’incidence de pacemaker post intervention, la mortalite dans les deux groupes de meme que les autres facteurs predictifs. Resultats : Sur 1160 patients, 143 deja porteurs de pacemaker et 60 par manque de donnees ECG ont ete exclus. 129 etaient porteurs d’un BBDc, parmi eux, 70 ont ete implantes d’un pacemaker au decours du TAVI (55%) versus 169 parmi 828 chez les non porteurs de BBDc (21,3%, p<0,003), 61 patients lors de la premiere semaine post TAVI, 9 dans l’annee qui a suivi. Parmi ce groupe de BBDc, les BBDc sans autre trouble conductif sur l’electrocardiogramme initial ont ete implantes a 33% (11 patients sur 33). En cas de BAV1 avec BBDc le taux d’implantation etait de 55% (11 patients sur 20). Sur 40 patients porteurs d’un BBDc avec hemibloc anterieur gauche (HBAG), 22 ont presente un trouble conductif de haut grade (55%). 64,3% des patients porteurs d’un BBDc, HBAG et BAV1 ont ete implantes en post TAVI. En cas d’hemibloc posterieur gauche associe a un BBDc, le taux de pacemaker etait de 100%. 11 deces ont ete constates a un an chez les patients porteurs de BBDc (13,3%) versus 36 deces parmi les patients non BBDc a un an (7,2%) avec en analyse multivariee, un odds ratio a 1,87(IC95%:0,89-3,94), p=0,095. Conclusion : Le bloc de branche droit complet est un facteur predictif majeur d’implantation de pacemaker post TAVI. L’implantation d’un pacemaker dans cette population en prevention primaire doit etre etudiee dans le cadre d’une etude prospective dediee.
RE-THINKING CHILD HEALTH SECURITY: AN INTROSPECTION OF EXCLUSIVE BREASTFEEDING PRACTICE IN YONSO AREA COUNCIL

Ghana has over the years adopted various health measures including exclusive breastfeeding (EBF) with the view of promoting the health security of the child which is a major concern of human security. Interestingly, the EBF concept has been received with a mixed reaction. While some nursing mothers practice EBF, others do not. Against this background, an exploratory study was conducted in the Yonso Area Council, a rural community in the Ashanti Region between June, 2015 and August, 2015, to establish among others, the level of nursing mothers’ knowledge on EBF and inhibiting factors to the practice of EBF. Data gathered through interview of 91 nursing mothers revealed that, the knowledge of nursing mothers on EBF and its effects on the health security of the child has been very high mainly due to health education from the Ghana Health Service. However, such high level of knowledge has not translated into full adoption of the concept by all nursing mothers in the study locality due to unemployment, erroneous understanding and inadequate family support. The paper advocates for a more health education and economic reforms to empower the rural poor, especially women, as a means of promoting and sustaining EBF practice and its concomitant child health security in Ghana, especially in the rural setting.
The theoretical basis of financial instruments research in the world economy system

The results of research on the theoretical basis for determining the nature and role of financial instruments in the world economy system are presented in this article. The systematization of the theoretical research approaches of financial instruments in the world economy system, determination of derivatives market factors which influence the development of international business, as well as justification of scientific and practical recommendations for improvement of derivatives market infrastructure management are the purpose of this research. It has been noted that the fact that international business subjects reach their efficiency limits (in terms of income and expenses) for a number of reasons, both subjective (shortcomings of the control systems used by them) and objective (the impossibility of further reducing costs due to the limitations of existing technology production and demand for products) encourages economic actors to search for new opportunities for obtaining economic benefits including usingfinancial instruments, particularly, derivatives. In the course of the research the types of financial instruments, conditions of stable derivatives market functioning have been analyzed, as well as derivative financial instruments market factors which influence the development of the international business have been identified. Over the course of the research the peculiarities of internal and external regulation of derivative financial instruments market have been identified. The author proposes scientific and practical recommendations on derivative financial instruments market infrastructure management improving in the world economy system, in particular: 1)improving the risk management system for derivative financial instruments and basic assets with the most extensive range of participants in this market; 2)the establishment of rational requirements for the amount of equity capital of market participants, taking into account both price and interest, and credit risks; 3) improving the quality of statistical reporting standards with disclosure of information for public access; 4) reforming legal rules related to offsetting agreements and the bankruptcy of multinational corporations; 5) coordination of actions of national and international authorities in the regulation of markets for derivative financial instruments on a global scale.
Two Essays on Short Sellers

We exploit a plausibly exogenous shock to shorting supply that occurs on dividend record dates to test the relation between shorting constraints and market quality. This shock arises due to a combination of equity settlement rules and the tax treatment of the payments in lieu of dividends that stock lenders receive when they loan their shares. Using ordinary dividend events between 2004 and 2016, we find a temporary degradation in liquidity on dividend record dates in the form of larger effective spreads. We find notably stronger effects for stocks with characteristics associated with less slack in equity lending supply, and for those paying larger dividends.
Percepções do ambiente construído e sua associação com a caminhabilidade objetiva

With the increasing burden of motorized transport, urban qualities have guided researchers to understand the influence of urban form on active travel. One of the strategies to evaluate the built environment is walkability, understood as the extent to which urban form may or may not be conducive to walking. This quality may be analyzed subjectively or objectively, considering perceptions or quantifications of environmental characteristics. Therefore, the general research objective is to analyze perceptions of the built environment related to walkability in a brazilian city. Perceptions were extracted from the Origin-Destination survey carried out for an Urban Mobility Plan of a case study – Rolândia/PR An Index was systematized as an objective and composed walkability measure, by census tracts, and analyzed in map overlays in relation to perceptions through the Kruskal-Wallis statistical procedure. Results indicate that functional, aesthetic and destination perceptions were associated to walkability, while perceptions of safety were less relevant. The study contributes for mobility guidelines in incorporating environmental perceptions as support to active travel to promote the sustainable city.
Fen Bilimleri Dersi Güneş Sistemi ve Ötesi Ünitesinde STEM Uygulamalarının Akademik Başarıya ve Kalıcılığa Etkisi

Bu calisma, fen bilimleri dersi 7. sinif ogretim programinda yer alan Gunes Sistemi ve Otesi unitesinde STEM uygulamalarinin kullanilmasinin, ogrencilerin akademik basarilarina ve kaliciliga olan etkisini incelemek amaciyla gerceklestirilmistir. Arastirma, 2017-2018 egitim-ogretim yili Bayburt il merkezinde bulunan Mehmet Akif Ersoy Ortaokulunun iki farkli subesinde ogrenim goren toplam 32 ogrenci ile gerceklestirilmistir. Calismada, on test-son test kontrol gruplu yari deneysel yontem kullanilmistir. Siniflardan biri deney grubu (n=15) olarak, digeri ise kontrol grubu (n=17) olarak rastgele secilmistir. Kontrol grubuyla mevcut ogretim programina bagli kalinarak islenen fen bilimleri dersi, deney grubunda mevcut programa STEM uygulamalari entegre edilerek islenmistir. Uygulama oncesinde ve sonrasinda, veri toplama araci olarak Gunes Sistemi ve Otesi Basari Testi (GSOBT) her iki gruba da uygulanmistir. Arastirmadan elde edilen veriler, SPSS 21 istatistik paket programi ile analiz edilmistir. Arastirmanin problemini ve alt problemlerini test etmek icin non- parametrik olan Mann Whitney U, Wilcoxon Isaretli Siralar testleriyle parametrik olan bagimli gruplar-t testi kullanilmistir. On testten elde edilen veriler degerlendirilmis olup gruplarin denk oldugu gorulmustur. Yapilan istatistiki calismalar sonucunda; STEM egitimine dayali ogretim uygulamalari ile desteklenmis fen bilimleri ogretim programinin, ogrencilerin akademik basarilarini artirdigi ve bu basaridaki artista kalicilik sagladigi gorulmustur.
Partially Coherent Compressive Phase Retrieval for Millimeter-Wave Massive MIMO Channel Estimation

Channel estimation is challenging for millimeter-wave (mmWave) massive MIMO systems. Leveraging the spatial sparsity of mmWave channels, compressive sensing (CS) based channel estimation been extensively studied. However, the mmWave hardware imperfections may introduce random phase distortions to the received pilots, which makes the conventional CS methods fail to estimate the channel. The compressive phase retrieval (CPR) method can be employed to solve this challenging problem. In this paper, we exploit the partial coherence in hybrid mmWave systems, i.e., the pilots sent from different radio frequency (RF) chains share the same phase distortion in the same time frame, while the phase distortions are different across different time frames. Based on this property, we propose an on-grid partially coherent CPR (PC-CPR) algorithm for mmWave channel estimation in the presence of severe phase distortions. Unlike the existing coherent channel estimation schemes that require perfect phase information or the noncoherent channel estimation schemes that ignore the phases of measurements, the proposed on-grid PC-CPR algorithm exploits the partial coherence property to estimate the sparse angle-domain channel vector. Furthermore, to solve the resolution limitation of the on-grid PC-CPR algorithm, we propose an off-grid PC-CPR algorithm that directly estimates the parameters of channel paths. The proposed partially coherent channel estimation framework subsumes the existing coherent and noncoherent channel estimation methods as special cases. Simulation results show that under the presence of random phase distortions, the proposed PC-CPR algorithms outperform noncoherent channel estimation methods with higher reliability and lower pilot overhead by leveraging the partial coherence.
Robust formation tracking for uncertain multi‐agent systems with unknown leader input

This study investigates the robust formation tracking problems for uncertain multi-agent systems(MASs). The leader is assumed to be linear case and the dynamics of the followers can be modelled as a high-order linear system with heterogeneous uncertainties and external disturbances. Only part of the followers can get the states of the leader and the control input of the leader cannot be obtained by any followers. Based on the relative information among agents, robust formation tracking protocols are proposed to achieve the desired formation tracking. It can be proven that the formation tracking error can be made arbitrarily small if the formation tracking feasibility condition holds. Finally, a simulation example is provided to illustrate the obtained theoretical results.
Facing market disruptions: values of elastic logistics in service supply chains

Market disruptions are commonly seen nowadays which directly affect demand. However, in logistics service supply chains, service capacity suppliers and service providers usually have to prepare logistics-service-capacity before demand is known. In this paper, we explore a logistics service supply chain with which the logistics-service provider (LP) has to decide the quantity of capacity to reserve to satisfy future demand in the upcoming season, which depends on whether market disruption occurs or not. The optimal capacity planning policy is determined and the impacts brought by the chance of market disruption are uncovered. Then, we consider the scenario with ‘elastic logistics’ in which capacity can be adjusted after the market state is known. We analytically establish the corresponding optimal dynamic policy and prove that it helps to stop the ripple effect from appearing. We explore the value of elastic logistics and propose conditions and measures to achieve Pareto improvement in the supply chain upon the adoption of elastic logistics. We extend the analysis to the case with the risk-averse LP and uncover that our qualitative findings remain robust, irrespective of the LP’s risk attitude.
Effectiveness of Increasing Realism Into Cybersecurity Training

This article describes how cybersecurity is a field that is growing at an exponential rate. In light of many highly publicized incidences of cyber-attacks against organizations, the need to hire experienced cybersecurity professionals is increasing. The lack of available workforce to fill open positions is alarming and organizations are finding that potential candidates with academic degrees and certifications alone are not as valuable as those with experience. Gaining rapid experience requires immersion into realistic virtual environments that mimic real-world environments. Currently, cybersecurity competitions leverage many technologies that immerse participants into virtual environments that mimic real-world systems to improve experiential learning. These systems are expensive to build and maintain, and to continuously improve realism is difficult. However, the training value of cyber competitions in which the participants cannot distinguish from real-world systems will ultimately develop highly experience cybersecurity professionals.
Neurological manifestations in Fabry disease

Fabry disease (FD) is a rare, progressive, multisystem and highly debilitating disease. FD is an X-linked lysosome storage disorder that results in α-galactosidase A deficiency. The subsequent accumulation of glycosphingolipids is more evident in vascular endothelium and smooth-muscle cells. The resulting effect of the deposition is generalized inflammation and vasculopathy, which can also affect the central and peripheral nervous system. FD progresses with kidney dysfunction, angiokeratoma of the skin, cardiomyopathy, cerebrovascular events and neurological disorders. In the present review, the neurological manifestations of FD are summarized with emphasis on cerebral vasculopathy, cochlear nerve dysfunction, psychiatric and cognitive symptoms, autonomic dysfunction and peripheral neuropathy. Enzyme replacement therapy is also discussed in the light of its more prominent effects when administered early in life, which make it essential to diagnose FD as soon as possible.
Geographic and environmental contributions to genomic divergence in mangrove forests

Assessing the relative importance of geographic and environmental factors to the spatial distribution of genetic variation may provide relevant information about the processes that maintain genetic variation in natural populations. With a globally wide but very restricted habitat distribution, mangrove trees are an interesting model for studies aiming to understand the contributions of these factors. Mangroves occur along the continent-ocean interface of tropical and subtropical latitudes, regions considered inhospitable to many other plant types. Here, we used landscape genomics approaches to investigate the relative contributions of geographic and environmental variables to the genetic variation of two black mangrove species, Avicennia schaueriana and Avicennia germinans, along the South American coast. Using single nucleotide polymorphisms, our results revealed an important role of ocean currents in the gene flow of A. schaueriana and isolation by environment as the pattern that best explains the genetic differentiation of A. germinans. Additionally, for both species, we observed significant correlations between genetic variation with evidence of selection and precipitation regimes, tidal variation, solar radiation and temperature patterns. These discoveries expand our knowledge about the evolution of mangrove trees and provide important information to predict future responses of coastal species to the expected global changes for this century.
A Dynamic WPT System With High Efficiency and High Power Factor for Electric Vehicles

Dynamic wireless power transfer (WPT) for charging electric vehicles (EVs) overcomes some of the problems associated with EVs battery size and weight as well as distance range limitation and long charging duration. High efficiency and fixed output voltage of WPT systems are of great importance for reducing operating cost and facilitating battery charging, respectively. On the other hand, utilizing the maximum power transfer capability of a WPT system leads to a capital cost saving of the system. In this article, the product of transferred power efficiency and input power factor (η·PF) is regarded as a criterion to make near full usage of the system power transfer capacity as well as reduce the capital and operating cost of the system. An optimal frequency-tracking method is proposed to maximize η·PF of the system taking into account possible abrupt changes in the coupling coefficient of the WPT system due to deviations of EV from alignment with the track along the road. In addition, the output voltage of the system is regulated simultaneously by an on-line adjustment of the primary inverter duty ratio. The optimal frequency-tracking method and voltage regulation are validated by extensive simulation and experimental results.
Implementing Electronic Health Records in New Zealand : A Critical Appraisal of Literature

New Zealand health sector has increasing demands in theageing population and ongoing inflation of medical costs. These demands are growing, and the importance of technology could optimise the healthcare sector performance. Advancement in technology drives Electronic Health Records implementation to add substantial value to health delivery systems. The investment and promotion of health informationinfrastructure have positioned New Zealand as a world leader in the field of primary care sector. Factors such as organisation structure, culture, leadership and workflow design are important to achieving successful implementation of Electronic Health Records. This review intends to critically appraise the advantages of EHRs over paper-based records (PBRs). It outlines the measures introduced by Ministry of Health to implement EHRs across the health sector in New Zealand. Furthermore, the review will provide an international comparison in implementing EHRs with that of New Zealand.
Implementing & evaluating a community of practice for health visiting - final report

This report presents the context, approach and findings arising from implementing and evaluating a Community of Practice (CoP) for Health Visitors across Kent and Medway funded by Health Education England (Kent, Surrey and Sussex) and built on the launch of the Communities of Practice concept in Kent and Medway (Keen et al 2013). The intention of the CoP, with its focus on health visiting practice, was to support a Health Visitor from each locality across Kent and Medway to: •develop their skills in practice development and clinical leadership •create effective learning cultures within which students and practitioners can flourish •explore how the effectiveness of health visiting can be demonstrated Two interrelated methodologies, action research and practice development were selected because they both focus on practical action in the workplace that is systematically implemented and evaluated through collaborative, inclusive and participative approaches. Three overarching processes (methods) were used to support the health visitor clinical leaders included active learning (Dewing 2008), action learning (McGill & Beaty 2001) and critical companionship - a helping relationship that focuses on helping a practitioner to learn (Titchen 2000). Within the lifetime of the project 18 co-researchers across two cohorts were recruited to the action learning sets; recruitment of co-researchers was undertaken in partnership with service managers. Four powerful influences emerged that impacted on the co-researchers’ participation in the project and also the potential for sustainability of the CoP project. Understanding the factors and strategies that influence the successful implementation of Communities of Practice is important to others who may be involved in similar initiatives. The limitations of the project are explored with recommendations for a range of organisations. Resources and outputs are shared and promoted widely to help others develop effective workplace cultures that use the workplace as the main resource for learning.