Miracle-dz/UniFAR-FTUs huggingface dataset:
The Reason Why rTMS and tDCS Are Efficient in Treatments of Depression

The present literature about possible mechanisms behind the effectivity of noninvasive electromagnetic stimulation in major depressive disorder (MDD) is not very rich. Despite extensive research in applications for clinical practice, the exact effects are yet not clear. We are comparing our previous results about the complexity changes induced by repetitive Transcranial Magnetic Stimulation (rTMS), and transcranial direct current stimulation (tDCS) which are known to modulate neural dynamics. Also, we are reviewing different biomarkers of complexity changes connected to depression, and how they change with the stimulation. TDCS is low-intensity TES, known to have polarity specific effects (neuromodulatory effects), and rTMS is inducing an electric field in the tissue circumstantially via Faraday's law. Both nonlinear modalities of electromagnetic stimulation may affect the levels of physiological complexity in the brain. We also compare the changes of complexity in electroencephalogram (EEG) and electrocardiogram (ECG), as potential future predictors of therapy outcome.
Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF?

Introduction Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients. Aim To evaluate whether Pseudomonas aeruginosa colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomography (HRCT) indices among patients with CF; to check if Pseudomonas colonization can predict exercise intolerance. Subjects Seventy-eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit. Results 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO2 peak: 79.1%) were evaluated: 33 were chronically colonized with Pseudomonas aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO2 peak% (p < 0.001), LCI (p < 0.001), as well as FEV1% (p < 0.001) and FVC% (p < 0.001). Pseudomonas colonization could predict VO2 peak% (p < 0.001, r2: −0.395). Conclusion Exercise capacity as reflected by peak oxygen uptake is reduced in Pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients.
Explicit order 3/2 Runge-Kutta method for numerical solutions of stochastic differential equations by using Itô-Taylor expansion

Abstract This paper aims to present a new pathwise approximation method, which gives approximate solutions of order 32 $\begin{array}{} \displaystyle \frac{3}{2} \end{array}$ for stochastic differential equations (SDEs) driven by multidimensional Brownian motions. The new method, which assumes the diffusion matrix non-degeneracy, employs the Runge-Kutta method and uses the Itô-Taylor expansion, but the generating of the approximation of the expansion is carried out as a whole rather than individual terms. The new idea we applied in this paper is to replace the iterated stochastic integrals Iα by random variables, so implementing this scheme does not require the computation of the iterated stochastic integrals Iα. Then, using a coupling which can be found by a technique from optimal transport theory would give a good approximation in a mean square. The results of implementing this new scheme by MATLAB confirms the validity of the method.
Enhanced flexural properties of aramid fiber/epoxy composites by graphene oxide

Abstract The reinforcing effect of graphene oxide (GO) in enhancing the flexural strength and flexural modulus of aramid fiber (AF)/epoxy composites were investigated with GO-AFs at a weight fraction of 0.1-0.7%. The flexural strength and flexural modulus of the composite reached 87.16 MPa and 1054.7 MPa, respectively, which were about 21.19% and 40.86% higher than those of the pure epoxy resin, respectively. In addition, the flexural properties and interfacial shear strength (IFSS) of composite reinforced by GO-AFs were much higher than the composites reinforced by AFs due to GO improved the interfacial bonding between the reinforcement material and matrix.
A Green Synthesis and Antibacterial Activity of N-Arylsulfonylhydrazone Compounds

Abstract A green method has been developed for the synthesis of N-arylsulfonylhydrazones via a simple grindstone procedure. By grinding mixtures of benzensulfonyl hydrazides and a series of aryl aldehydes or ketones in the mortar using L-tyrosine as catalyst, 24 N-arylsulfonylhydrazones were synthesized in a few minutes with high yield. All compounds were screened for their antibacterial activities. Most of them exhibit some antibacterial activities especially for 3d, 3l and 3v showing high activity against Staphylococcus aureus and Escherichia coli.
LOINC: Origin, development of and perspectives for medical research and biobanking – 20 years on the way to implementation in Germany

Abstract Twenty-five years of LOINC (Logical Observation Identifier Names and Codes) and almost 20 years of experience with the implementation of LOINC in Germany – without having so far achieved a binding national definition of or a relevant routine use of LOINC in laboratory data communication. This article sketches the development of LOINC use in Germany since the year 2000 on the basis of grey literature. For the first time, the use of LOINC in Germany is experiencing a significant impetus at the national level: On the one hand, the current health legislation with its stipulations for a legally defined electronic patient record provides the necessary framework for nationwide stipulations; on the other hand, there is a significant impulse from the German Medical Informatics Initiative (MII) out of the medical research field for implementing a uniform LOINC subset. In recognition of the 25th anniversary of the LOINC nomenclature (1995–2019), the article traces the emergence of LOINC – which is characterized by interactions between European (EUCLIDES, READ, NPU) and US (HL7, LOINC, SNOMED CT) developments and the interplay of various standardization initiatives. Different national definitions and e-health strategies resulting from this history will be a challenge for the future e-health harmonization in the EU. The concerns of medical research and biobanking must be taken into account here, since the standardization of lab data according to international nomenclatures is of utmost importance for them.
SY03-1-3ISAM FELLOWSHIP PREVALENCE OF HIV INFECTION AMONG THE OVER 18 YEAR OLD SUBSTANCE ABUSERS IN MWANZA URBAN, TANZANIA

Objective. The problem of substance abuse is found all over the world. Abused substances are psychoactive and may drive abusers to engage into unsafe sexual practices and criminal activities. For injecting drugs, the apparatus used often unsterile and shared which predispose the users to blood borne infections. The purpose was to determine the role of substance abuse in transmission of HIV and its magnitude in Mwanza Urban Tanzania. Methods. A cross-sectional study of 774 substance abusers aged 18 years and above was conducted from March to June 2012. Data collection involved use of a questionnaire (Face to face approach) and collection of blood to determine the serological status, while urine samples were used to detect illegal drugs which had been used. Results. Cannabis and alcohol were highly abused 83.0% and 74.2% respectively followed by khat 38.3 %. Heroin smoking was 34.0% and injection was 6.1%. HIV infection was detected in 8.6% of the substance abusers, while Hepatitis B and C were 3.8% and 2.9% respectively and 2.5% Syphilis. Conclusion. HIV infection in substance abusers was higher 8.6% with 6.3% among intravenous drug users. Education on consequences of psychoactive substances and unsafe sex should be given to the substance abusers.
Sexual and reproductive health risks among key populations vulnerable to HIV in Kenya

In Kenya an estimated 1.5 million people are living with HIV; and in 2009 80,000 people died from AIDS related illnesses. Many people are still not being reached by HIV prevention and treatment services. Among the most affected are vulnerable populations who are hidden and are largely outside the net of prevention, care and treatment services. Such groups have an increased risk of HIV infection and onward transmission to the general population. Existing laws criminalize their practices and a majority is confronted with high levels of stigma and discrimination, which present individual barriers to control risk of HIV infection and poor SRH outcomes. In Kenya, key vulnerable population groups include, but are not limited to, sex workers (female sex workers, male sex workers and their clients); men who have sex with men; mobile populations; and injecting drug users. Currently, HIV and SRH prevention needs of these groups are not evident across the compendium of prevention framework in Kenya where programmes have been implemented it has sometimes only been partial or episodic. Therefore addressing HIV and SRH needs of these populations is necessary to mitigate risk factors and to prevent HIV infection in a mixed HIV epidemic like Kenya. Currently, a better understanding is required of the factors associated with sexual risk behavior including sexual and reproductive health needs among these populations groups to effectively develop tailored interventions. The studies presented in this thesis focus on two of these key population groups: female sex workers and male sex workers but also highlight the role of persons who are HIV positive in the dynamics of the HIV epidemic. The studies presented deepen the understanding of the risks of the populations of interest and seek to identify effective prevention strategies to control HIV and sexual and reproductive risks. In Kenya interventions for female sex workers mostly focus on risk reduction strategies (peer education, IEC material etc) and emphasis on condom use with clients. However, available evidence suggests sustained high STI and HIV rates among sex workers. In Chapter 4.1 we assessed the social and legal contexts that underpin the high levels of sexual and physical violence that pervade sex work in Kenya. We therefore explored factors that underlie sex workers vulnerabilities to sexual and physical violence and how it impacts on their HIV risk. Eighty-one female sex workers shared their experiences in eight focus-group discussions. The women's narratives show that sex workers face dou-
The Effect of Zhejiang Fritillaria Thunbergii Against Immunological CP/CPPS

Objective:To develop a mice model of nonbacterial chronic prostatitis.To explore the treatment of chronic prostatitis Pui the mechanism to evaluate its clinical efficacy prostatitis.Methods:Aged Sprague-Dawley mices were castrated and injected Aluminum Hydroxide immune file. (0.5 mg/day,s.C.)for 30days.Prostates were harvested after 30 days injection.Prostatic tissue was examined histologically for degree of inflammation.Pui to observe the impact of pathological model.Results: Different degree of inflammation and lymphocytic infiltration was found in prostate after injection.Endovascular secretions significantly increased.Interstitial infiltration of inflammatory cells was decreased fibrosis also decreased noticeably.Compared with model group,there was a significant difference(P0.05). Most animals laminin(LN) and fibronectin(FN) was weakly positive,a few animals positive linear gland in the basement membrane,interstitial and perivascular Flake point spread in Leydig,Compared with model group,there was a significant difference(P0.05). Conclusion:Injection of estradiol benzoate can induce prostatic inflammation similar to clinical nonbacterial chronic prostatitis and it will be a good way to found an animal prostatitis mode1.Big Shell is reducing pathological model inflammatory response,reducing the degree of fibrosis.
Bone grafting in small animal orthopaedic surgery

Bone grafting is a useful technique for a variety of orthopaedic injuries, but general practitioners may not routinely use it. This article aims to ‘demystify’ the subject of bone grafting and provide step-by-step guides for the harvest of autogenous cancellous bone grafting (grafts taken from the patient), as well as to provide information on the selection and use of ready-to-use allografts (grafts taken from donors of the same species) and other more recent modalities.
Design and Analysis of Finite Impulse Response Using Gate Diffusion Input (GDI) Circuits

Integrated Circuits technology advancements have consistently migrated to smaller feature sizes over the last four decades years, forcing more functional circuits to be placed on each chip. The increased density can be used to decrease cost and/or increase functionality as can be seen by Moore's law. Since higher performance and lower power consumption are becoming attainable by not further following the Moore’s law, there is an intensive competition among the manufacturers to use finer geometries. The new Gate-Diffusion-Input (GDI) based circuit is the focus of attention in designing digital circuit, less power is required while more efficiency is obtained. GDI-based circuit resembles to CMOS transistors but have fewer transistors with more functionality and higher performance capability. This study addresses the design and analysis of FiniteImpulse-Response (FIR) block which are done, using basic blocks implemented with GDI-based circuits. In this study, design of 8-tap FIR design based on GDI cells has been implemented and compared with NMOS based circuits, and CMOS based circuits. The results show 8-tap FIR design using GDI has lower power consumption, higher performance, and less die area.
Efficacy of the Digital Therapeutic Mobile App BioBase to Reduce Stress and Improve Mental Well-Being Among University Students: Randomized Controlled Trial

Background University students in the United Kingdom are experiencing increasing levels of anxiety. A program designed to increase awareness of one’s present levels of well-being and suggest personalized health behaviors may reduce anxiety and improve mental well-being in students. The efficacy of a digital version of such a program, providing biofeedback and therapeutic content based on personalized well-being metrics, is reported here. Objective The aim of this study was to test the efficacy and sustained effects of using a mobile app (BioBase) and paired wearable device (BioBeam), compared with a waitlist control group, on anxiety and well-being in university students with elevated levels of anxiety and stress. Methods The study employed a randomized, waitlist-controlled trial with assessments at baseline, 2 weeks, postintervention (4 weeks), and follow-up (6 weeks). Participants were eligible if they were current full-time undergraduate students and (1) at least 18 years of age, (2) scored >14 points on the Depression, Anxiety, and Stress Scale-21 items (DASS-21) stress subscale or >7 points on the DASS-21 anxiety subscale, (3) owned an iOS mobile phone, (4) did not have any previous psychiatric or neurological conditions, (6) were not pregnant at the time of testing, and (7) were able to read and understand English. Participants were encouraged to use BioBase daily and complete at least one course of therapeutic content. A P value ≤. 05 was considered statistically significant. Results We found that a 4-week intervention with the BioBase program significantly reduced anxiety and increased perceived well-being, with sustained effects at a 2-week follow-up. Furthermore, a significant reduction in depression levels was found following the 4-week usage of BioBase. Conclusions This study shows the efficacy of a biofeedback digital intervention in reducing self-reported anxiety and increasing perceived well-being in UK university students. Results suggest that digital mental health interventions could constitute a novel approach to treat stress and anxiety in students, which could be combined or integrated with existing therapeutic pathways. Trial Registration Open Science Framework (OSF.io) 2zd45; https://osf.io/2zd45/
Investigation on Cow Cryptosporidiosis in Some Regions of Yantai

In order to know the prevalence of cow Cryptosporidium in Yantai region,565 fecal samples were taken from six diary farms in Haiyang,Laiyang,Muping,Zhaoyuan.The real-time PCR method was used to detect and analyze the association between the cow Cryptosporidium infection and diarrhea,season,ages,etc.The result showed that the total infection rate of Cryptosporidium was 10.44%(59/565). The Cryptosporidium infection rate in diarrhoeal cows is 20.13%(32/159). The infective rates of calves,young cows and adult cows were 18.09%,11.85%,3.72%,respectively.In addition,the Cryptosporidium infection mostly happened in winter and spring.According to the survey,the cow Cryptosporidium etiology exists in some parts of Yantai region.So the attention should be taken seriously to prevent the cow Cryptosporidium.
Nerve Repair and Orthodromic and Antidromic Nerve Grafts: An Experimental Comparative Study in Rabbit

Purpose Although many surgeons have anecdotally described reversing the polarity of the autograft with the intent of improving regeneration, the optimal orientation of the autogenous nerve graft remains controversial. The aim of this study was to compare (1) the outcomes of orthodromic and antidromic nerve grafts to clarify the effect of nerve graft polarity and (2) the outcome of either form of nerve grafts with that of nerve repair. Methods In 14 of the 26 rabbits used in this study, a 1 cm defect was made in the tibial nerve. An orthodromic nerve graft on one side and an antidromic nerve graft on the other were performed using a 1.2 cm long segment of the peroneal nerve. In the remaining 12 rabbits, the tibial nerve was transected completely and then repaired microscopically on one side but left untreated on the other. Electrophysiologic studies were performed in all animals at 8 weeks after surgery, and the sciatic nerves were harvested. Results Compound motor action potential was visible in all rabbits treated by nerve repair but in only half of the rabbits treated by nerve graft. There was no significant difference in the compound motor action potential, nerve conduction velocity, or total number of axons between the orthodromic and antidromic nerve graft groups. However, in both groups, the outcome was significantly poorer than that of the nerve repair group. Conclusion There was no significant difference by electromyographic or histologic evaluation between orthodromic and antidromic nerve grafts. Direct nerve repair with moderate tension may be a more effective treatment than nerve grafting.
Relation and Concordance of Two Methods for the Evaluation of Airway Hyperresponsiveness in Obese Adolescents

Cieslak F, Lopes WA, Titski ACK, Timossi LS, Levandoski G, Vilela Junior GB, Rosário Filho NA, Leite N. Relation and Concordance of Two Methods for the Evaluation of Airway Hyperresponsiveness in Obese Adolescents. JEPonline 2013;16(3):59-68. This study determined the relation and concordance of two methods for the evaluation of airway hyperresponsiveness in 15 obese adolescents (9 females and 6 males). Forced expiratory volume (FEV1) was evaluated at baseline and at 3, 5, 10, 15, and 30 min after a physical exercise test. Inhalation of 4.5% hypertonic saline was performed using a large-volume ultrasonic nebulizer continuously at 0.5, 1, 2, 4, and 8 min until the FEV1 decrease was ≥15% in relation to baseline. The exercise-induced bronchospasm (EIB) was considered positive if the FEV1 decrease was <10% in relation to the baseline. For the concordance of the FEV1 fall of ≥10% for exercise with the FEV1 fall of ≥15% of hypertonic saline (k=0.67; P=0.05), the linear regression intermethod was used (R=0.751; P<0.001). The intraclass correlation coefficient was strong (ICC=0.86; P<0.001). The findings indicate that the two methods for the detection of airway hyperresponsiveness probably have the same trigger point, indicating that both methods promoted bronchial hyperosmolarity and possess a degree of concordance.
Cultural Diversity and Digitalization of Marketing Communica- tion: Agenda for Future Research

Drawing on cross-cultural research, the study highlights the applicability of GLOBE cultural framework for international digital marketing communication research (IDMC). The review of literature shows that we lack knowledge about what role culture plays in the use and effectiveness the of several innovative digital marketing tools, namely consumer-generated advertising (CGA), consumer-generated brand communication (CGBC), firm-created advertising, and branding in digital space. The study proposes avenues for IDMC research by embracing the role of culture, the pursuit of which would be beneficial to both academicians and managers. Lastly, the study discusses the usefulness of several research methods for IDMC research.
Facial Expression Recognition Using Adaptive Template

In this paper, we presented a classification method of facial expressions displayed in images or video sequences using adaptive template. In our approach, we trained the seven basic expressions templates known as “Happiness”, “Anger”, “Disgust”, “Fear”, “Surprise”, “Sadness” and “Neutral”. Then we take an input face image with unknown facial expressions and calculate the nearest distance between the feature points on that input face image and the feature points on each of the seven facial expressions templates, therefore to find the closest match. Experimental result shows that adaptive template is an effective method to identify facial expressions in an image that contains human face with unknown emotions.
Cloning and study of vitellogenin expression in wild cyprinid Petroleuciscus esfahani as a 1 biomarker of endocrine disruption along the Zayandeh Roud River, Iran

12 Aquatic environments are the ultimate sink for most of anthropogenic pollutants. The Zayandeh 13 Roud River is the most important river in the central Iranian Plateau, supplying water resources 14 to a large population. In order to determine the potential occurrence and in vivo effects of EDCs 15 with estrogenic properties we analyzed the wild populations of an extensively distributed 16 endemic fish species, Petroleuciscus esfahani. For this purpose, specimens were caught from 17 two sites upstream and two sites downstream of the expected major anthropogenic pollution 18 sources. P. esfahani full length cDNAs for vitellogenin (vtg), with 4,177 base pairs (bp) 19 encoding a 1,339 amino acids (aa), and for β-actin (actb), with 1,776 bp encoding a 375 aa, were 20 amplified and cloned. Hepatic vtg mRNA expression levels were measured by quantitative real21 time PCR. Condition factor, gonadosomatic index and sex ratio were calculated and compared 22 with vtg expression. Gonad histology was performed to study the possible presence of intersex 23 condition. Detection of vtg transcripts in male individuals from the two downstream sampling 24 sites supports the hypothesis of exposure to estrogenic compounds in these regions. Higher vtg 25 expression in male individuals, together with reduced gonad size and condition factor, in 26 specimens from the third site, located downstream of the major steel mill plant, suggest a major 27 endocrine disruption in this area. 28