Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Manufacturing Companies According to their Green Capabilities in the Context of Developing Countries

Having environmentally friendly products and processes in order to provide sustainable competitive advantage has become an important issue for companies which are a step forward in globalizing economy. Firstly, this study aimed to investigate what the situation of manufacturing companies about eco-innovation and green capabilities in the context of developing country, secondly if companies vary according to their sector and capital structure in green capabilities. For this aim, a survey was performed among 278 manufacturing company in Turkey. Statistical analysis is performed by Lisrel 8.80 and SPSS 18.0 statistical software. Findings show that while there is no difference between companies according to the sector, firms vary on the base of the capital structure about green capabilities. Keywords: Eco-innovation, Green capabilities, Developing countries, Turkey .
Diversity of Bacterial Populations on the Tongue Dorsa of Patients with Halitosis and Healthy Patients

ABSTRACT The primary purpose of the present study was to compare the microbial profiles of the tongue dorsa of healthy subjects and subjects with halitosis by using culture-independent molecular methods. Our overall goal was to determine the bacterial diversity on the surface of the tongue dorsum as part of our ongoing efforts to identify all cultivable and not-yet-cultivated species of the oral cavity. Tongue dorsum scrapings were analyzed from healthy subjects with no complaints of halitosis and subjects with halitosis, defined as an organoleptic score of 2 or more and volatile sulfur compound levels greater than 200 ppb. 16S rRNA genes from DNA isolated from tongue dorsum scrapings were amplified by PCR with universally conserved bacterial primers and cloned into Escherichia coli. Typically, 50 to 100 clones were analyzed from each subject. Fifty-one strains isolated from the tongue dorsa of healthy subjects were also analyzed. Partial sequences of approximately 500 bases of cloned inserts from the 16S rRNA genes of isolates were compared with sequences of known species or phylotypes to determine species identity or closest relatives. Nearly complete sequences of about 1,500 bases were obtained for potentially novel species or phylotypes. In an analysis of approximately 750 clones, 92 different bacterial species were identified. About half of the clones were identified as phylotypes, of which 29 were novel to the tongue microbiota. Fifty-one of the 92 species or phylotypes were detected in more than one subject. Those species most associated with healthy subjects were Streptococcus salivarius, Rothia mucilaginosa, and an uncharacterized species of Eubacterium (strain FTB41). Streptococcus salivarius was the predominant species in healthy subjects, as it represented 12 to 40% of the total clones analyzed from each healthy subject. Overall, the predominant microbiota on the tongue dorsa of healthy subjects was different from that on the tongue dorsa of subjects with halitosis. Those species most associated with halitosis were Atopobium parvulum, a phylotype (clone BS095) of Dialister, Eubacterium sulci, a phylotype (clone DR034) of the uncultivated phylum TM7, Solobacterium moorei, and a phylotype (clone BW009) of Streptococcus. On the basis of our ongoing efforts to obtain full 16S rRNA sequences for all cultivable and not-yet-cultivated species that colonize the oral cavity, there are now over 600 species.
The mediating effect of e-satisfaction and the moderating effect of convenience towards e-loyalty among Internet banking users in northern region of Malaysia

Research on online customer loyalty among internet banking users is important because of the threat posed by phishing and other related issues. The literature has shown that it is a major concern, especially in Malaysia. This study examines the factors influencing eLoyalty such as eSatisfaction, eCommitment, eTrust, privacy, security, website quality and convenience among the internet banking users in Malaysia. The objectives of the study are to analyse the direct effect of eSatisfaction, eCommitment, eTrust towards eLoyalty and the mediating effect of eSatisfaction between privacy, security and website quality on eLoyalty. Another objective is to observe the moderating role of convenience between eSatisfaction and eLoyalty. The underpinning theory used to develop the study’s framework is based on Oliver’s Four-Stage Loyalty Model. An intercept data collection approach was chosen due to the nature of online users as well as the industry. A total of 427 datasets was employed for final analysis, performed using SPSS and SmartPLS-SEM (Partial Least Squares-Structural Equation Modeling). The results of the analysis show that all hypotheses are supported and only one is rejected. The study has established the direct relationship between eSatisfaction, eCommitment and eTrust towards eLoyalty. In addition, the study has confirmed the mediating effect of eSatisfaction between privacy and eLoyalty, security and eLoyalty and website quality on eLoyalty. However, the moderating role of convenience was found to be not significant indicating that there is a constant effect between eSatisfaction and eLoyalty. The study also discusses the theoretical and practical contributions as well as the limitations of the study and recommendations for future research.
Nonfinancial Firms as Large Shareholder Use Dividend Policy for Management Monitoring in Brazil

The paper analyzes whether nonfinancial firms as large blockholders of the Brazilian firm shape dividend policy. Under the Agency Theoretical framework a set of good corporate governance practices is suggested as able to control management activity and prevent managers from incurring in moral hazard problems and the emergence of excessive management power as predicted by the Managerial Power Hypothesis. In this context, the Management Monitoring Hypothesis proposes that dividend policy may be used as a management control mechanism given that dividend distribution affects the free cash flow available for managers. Dividend models were estimated by the Generalized Method of Moments (GMM) for an unbalanced panel data, composed of 1.890 firm-year observations of 234 companies listed on the BM&FBovespa, in the period 1996-2012. The results indicate that nonfinancial firms as large shareholders increase dividend payout which leads to the reduction of free cash flow. This result is in accordance with the monitoring hypothesis which predicts the reduction of free cash flow available for managers through dividend policy.
Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1*

The telomeric protein TRF1 negatively regulates telomere length by inhibiting telomerase access at the telomere termini, suggesting that the protein level of TRF1 at telomeres is tightly regulated. Regulation of TRF1 protein abundance is essential for proper telomere function and occurs primarily through post-translational modifications of TRF1. Here we describe RLIM, a RING H2 zinc finger protein with intrinsic ubiquitin ligase activity, as a TRF1-interacting protein. RLIM increases TRF1 turnover by targeting it for degradation by the proteasome in a ubiquitin-dependent manner, independently of Fbx4, which is known to interact with and negatively regulate TRF1. Whereas overexpression of RLIM decreases the level of TRF1 protein, depletion of endogenous RLIM expression by small hairpin RNA increases the level of TRF1 and leads to telomere shortening, thereby impairing cell growth. These results demonstrate that RLIM is involved in the negative regulation of TRF1 function through physical interaction and ubiquitin-mediated proteolysis. Hence, RLIM represents a new pathway for telomere maintenance by modulating the level of TRF1 at telomeres.
What Works in Public Service Leadership: Exploring the Potential

The Scottish Approach to public service reform places significant emphasis on partnership and collaboration. Successfully reforming public services therefore calls for a kind of leadership that fosters and promotes partnerships and collaboration within, between and beyond individual services. This paper presents an overview of some of the key concepts that underpin collaborative leadership in public service settings and reflects on some of the emerging themes identified by What Works Scotland that support change around public service reform (PSR) when working within the complex dynamics of community planning partnerships (CPPs) and across public service settings. This paper aims to provide an understanding of the forms of leadership that are necessary for the future of Scottish public services and is guided by the following two questions: How is effective public service leadership enacted? What kind of public service leadership enables productive partnerships and collaboration? The paper highlights that in the future those working in public services will frame and lead provision of their services and set the direction for and support service improvement in partnership with those engaging with the service. Co-production with service users will become the norm. Not only will this involve moving decision-making much closer to the point of delivery, it will also move beyond public service producer-capture.
The importance of synthetic drugs for type 2 diabetes drug discovery

Introduction: Type 2 diabetes mellitus (T2DM) is a major metabolic, multi-causal and heterogeneous disorder which causes significant morbidity and mortality with considerable burden to healthcare resources. The number of deaths due to T2DM highlights the insufficiency of the currently available drugs for controlling the disease and its complications and more needs to be done. Areas covered: This paper reviews the updated pathobiology of T2DM that should be targeted in drug discovery. Further, the article provides discussion on the mechanism of action, side effects and structure of the currently available synthetic drugs. The authors specifically evaluate two newer classes of anti-diabetic agents: dipeptidyl peptidase IV (DPP-4) and sodium-glucose transporter-2 (SGLT2). They also present information on newer synthetic compounds. The article also highlights the key interactions between synthetic compounds and DPP-4 active site residues for rational drug design. Expert opinion: Numerous anti-hyperglycaemic drugs are currently available but many are limited by their adverse effects. The identification of the 3D structure of DPP-4 has opened new avenues for design, thus aiming to produce drugs that directly exploit the structural characteristics of this binding site. Further, structural- and ligand-based screening techniques have been developed for designing novel DPP-4 and SGLT2 inhibitors. There has also been progress with the design and development of novel T2DM therapeutics including: PPARα/ dual agonists, Sirtuin 1 activators, glycogen phosphorylase inhibitors and protein tyrosine phosphatase 1B inhibitors. Finding new targets and synthesis methods is still essential but it is becoming accepted that no diabetic therapy is ‘best suited' with each patient responding differently.
Colinearité et Instabilité Numérique dans le Modèle Linéaire

Nous donnons dans cet article l'expression du coefficient de correlation multiple dans un modele lineaire en fonction des coefficients de correlation. Cette expression permet d'analyser d'un point de vue numerique l'instabilite des estimations dans le cas de variables explicatives quasi colineaires que l'on rencontre frequemment dans le modele lineaire et le modele autoregressif L'approche numerique, que nous montrons sur deux exemples, complete ainsi l'approche habituelle de la quasi colinearite, fondee sur les proprietes statistiques des estimateurs.
Surve on “ Travel Recommendation Using POI of User

Big data increasingly benefit both research and industrial area such as health care, finance service and commercial recommendation. This paper presents a personalized travel sequence recommendation from both travelogues and community-contributed photos and the heterogeneous metadata (e.g., tags, geo-location, and date taken) associated with these photos. Unlike most existing travel recommendation approaches, our approach is not only personalized to user’s travel interest but also able to recommend a travel sequence rather than individual Points of Interest (POIs). Topical package space including representative tags, the distributions of cost, visiting time and visiting season of each topic, is mined to bridge the vocabulary gap between user travel preference and travel routes. We take advantage of the complementary of two kinds of social media: travelogue and community-contributed photos. We map both user’s and routes’ textual descriptions to the topical package space to get user topical package model and route topical package model (i.e., topical interest, cost, time and season). To recommend personalized POI sequence, first, famous routes are ranked according to the similarity between user package and route package. Then top ranked routes are further optimized by social similar users’ travel records. Representative images with viewpoint and seasonal diversity of POIs are shown to offer a more comprehensive impression. We evaluate our recommendation system on a collection of 7 million Flickr images uploaded by 7,387 users and 24,008 travelogues covering 864 travel POIs in 9 famous cities, and show its effectiveness. We also contribute a new dataset with more than 200K photos with heterogeneous metadata in 9 famous cities.
Predicting disease genes based on normalized protein modules and phenotype ontology

Predicting disease genes in PPI network has attracted a lot of attention over the years. Based on the assumption that the phenotypes of the genes in the same complex where candidate gene located in are more similar to disease, the candidate gene is more possible to be disease gene, we propose a new disease gene identification method based on protein complex phenotype similarity. First, our method mines protein complexes in PPI network by resolution-limit-free clustering algorithm and maps the candidate genes to complexes. Second, we define phenotype similarity according to phenotype ontology, and calculate phenotype similarity value between gene and disease. Third, we add up the phenotype similarity value of whole genes in the complex as weight of candidate gene and rank the candidate gene according to the sum of phenotype similarity value. Finally, we test our method by leave-one-out cross validation. The results show that our method is effective and outperforms other methods such as NetRank, NetScore, NetZcore, Flow, RWR and NDRC. Importantly, we predict the disease gene of Prader-Willi syndrome (MIM: 176270) and Renal tubular dysgenesis (MIM: 267430) successfully, which do not exist in our disease-gene datasets but exists in online databases and scientific publications.
Counterion-only electrical double layer: A constrained entropy approach

A counterion-only double-layer theory is developed taking a constrained entropy maximization approach based on an isothermal thermodynamic system. The double-layer interaction free energy per unit area between two charged planar surfaces is obtained in a consistent manner for the boundary conditions of constant surface charge density and charge regulation. Once applied to the nonpolar medium, it reveals that the electrical double-layer repulsion is weak and long-ranged. Asymptotically, the interaction decays as a power law, in contrast with that in the presence of an ion reservoir which decays exponentially at large surface separation. The applicability of the counterion-only model for describing colloidal stability in nonpolar media is discussed.
Characterizing Graphs with Crossing Number at Least 2

Our main result includes the following, slightly surprising, fact: a 4‐connected nonplanar graph G has crossing number at least 2 if and only if, for every pair {e,f} of edges having no common incident vertex, there are vertex‐disjoint cycles in G with one containing e and the other containing f.
NEUROTENSIN AND THERMOREGULATION *

The physiological roles of the tridecapeptide neurotensin (NT) have not yet been clearly defined. Its heterogeneous distribution in brain and gut and the manifold effects observed after central nervous system (CNS) or systemic injection allow preliminary formulation (see Prange and Nemeroff, this volume) but not closure. Our group first reported the hypothermic effect of NT in 1976. * This study demonstrated that NT injected intracisternally (i.c.) caused a dose-dependent decrease in the colonic temperature of mice in a 4°C environment. The lowest effective dose was 30 ng (FIG. 1). At an ambient temperature of 25"C, animals also responded to i.c. NT with loss of body temperature, though the effect was less pronounced than at 4°C. Somatostatin (SRIF), substance P, melanocytestimulating hormone inhibiting factor (MIF-I), luteinizing-hormone releasing hormone (LHRH) and thyrotropin-releasing hormone (TRH) were not effective in inducing hypothermia at 4°C after i.c. injection of doses equimolar to 30 of NT. These findings have been confirmed in several It is noteworthy that NT given peripherally appears to lack a hypothermic effect; intravenous (i.v.) administration, at whatever ambient temperature, was ineffective in doses as large as 100 pglkg-I. Using NT fragments and pamino-acid-substituted analogs of NT, synthesized and generously supplied by Dr. Jean Rivier of the Salk Institute, we next sought to identify the part of the NT moleculeY responsible for hypothermic activity. DTyr'I-NT, NT-NHCH3, and bombesin, a peptide derived from frog skin, were found to be more potent hypothermic agents in mice at 4°C than NT when injected i.c. in doses equimolar to 30 pg NT. The carboxyl terminus and, specifically, the two adjacent arginine residues were shown to be crucial for hypothermia (TABLE 1). These structureactivity findings are largely supported by Rivier et a1 . l o The hypothermic effect of bombesin confirms the original report by Brown and Vale. " The impetus for the examination of the thermoregulatory effects of NT came from the use of a pharmacological screening test for CNS activity of peptides. " The interactions of NT with CNS depressants is discussed in another chapter of these proceedings, but the profound potentiation by i.c. NT of a narcotic dose of pentobarbital deserves mention. This potentiation was shown to be due to a marked decrease in the metabolism of ["HI pentobarbital in brain, blood, and liver of rats.I2 As seen in TABLE 2, the hypothermia elicited by 50 mg/kg pentobarbital is suppressed at 33 minutes and augmented after 66 minutes after i.c. NT in mice at 25"C, although no clear doseresponse relationship is apparent. This effect of
Economic evaluation of a tertiary telepsychiatry service to an island

The island of Jersey is located 160 km south of Britain and 23 km from northwest France. The island has well-established primary and secondary mental health services, but tertiary services have to be purchased from UK mainland service providers. A pilot study of telepsychiatry was conducted, using videoconferencing to access tertiary mental health services from the UK. During a six-month study period, five patient consultations and six specialist presentations were carried out. The total cost of using videoconferencing to deliver tertiary mental health services not ordinarily available in Jersey was £3483.06. The costs of using the traditional model instead would have been £12,975.00. The threshold at which videoconferencing became cheaper than travel was between five and six telemedicine episodes per year; the actual workload during the pilot study was 22 episodes per year. The study suggests that telemedicine is cost-effective for providing tertiary mental health services not ordinarily available in Jersey.
Molecular study of electron transfer flavoprotein α‐subunit deficiency in two Japanese children with different phenotypes of glutaric acidemia type II

Background Electron transfer flavoprotein is a mitochondrial matrix protein composed of alpha‐ and beta‐subunits (ETFα and ETFβ, respectively). This protein transfers electrons between several mitochondrial dehydrogenases and the main respiratory chain via ETF dehydrogenase (ETF‐DH). Defects in ETF or ETF‐DH cause glutaric acidemias type II (GAII).
Financial Anomalies and Information Uncertainty

We examine whether rational investor responses to information uncertainty (IU) explain properties of and returns to several financial anomalies (post-earnings announcement drift, value-glamour, and accruals anomalies). Consistent with a rational learning explanation, we find that: (1) higher IU signals have more muted initial market reactions; (2) extreme anomaly portfolios are characterized by securities with higher IU than non-extreme portfolios; (3) within the extreme anomaly portfolios, high IU securities are more prevalent and earn larger abnormal returns than low IU securities; and (4) the abnormal returns to high IU securities converge to the abnormal returns to low IU securities as the post-portfolio formation period lengthens. Further tests show that prior evidence of greater anomaly profitability for higher idiosyncratic volatility securities is largely explained by these securities having greater information uncertainty.
Latency Analysis of Automobile ABS Based on AADL

ABS latency analysis is difficult issue in design phase. In this article the causes of each system delay is analysed and end to end flow delay algorithm in the worst case is used, Architecture Analysis and Design Language(AADL) is studied to model the system. End to end flow latency has been computed and compared with the expected value by AADL tool OSATE. The result shows that the analysis method can be used to resolve the flow latency bottleneck and it provides a new approach to system design and optimization.
Port isolation enhancement via active integration for a UWB MIMO antenna system

In this paper, a new approach of port isolation for UWB MIMO antennas is investigated through active integration with a power amplifier (PA). Instead of 50Ω based design, a co-design approach based on the complex impedance of the PA and the antenna is adopted for better MIMO antenna matching and port isolation. Such approach does not require extra decoupling networks. The integrated antenna system covers 1.5-6GHz and shows minimum port isolation improvement of 5.5dB. The minimum efficiency and highest envelop correlation coefficient are found to be 62% and 0.115 respectively over the band 1.5-6GHz.