Miracle-dz/UniFAR-FTUs huggingface dataset:
Auxin-BR Interaction Regulates Plant Growth and Development

Plants develop a high flexibility to alter growth, development, and metabolism to adapt to the ever-changing environments. Multiple signaling pathways are involved in these processes and the molecular pathways to transduce various developmental signals are not linear but are interconnected by a complex network and even feedback mutually to achieve the final outcome. This review will focus on two important plant hormones, auxin and brassinosteroid (BR), based on the most recent progresses about these two hormone regulated plant growth and development in Arabidopsis, and highlight the cross-talks between these two phytohormones.
TOWARDS SYSTEMATIC INCONSISTENCY IDENTIFICATION FOR PRODUCT SERVICE SYSTEMS

Value shift towards services led to emergence of product-service systems (PSS) as intertwined products and services. PSS development requires collaborating teams with higher domain diversity to tackle service side as well as product side. Since every domain employs a particular set of tools and models, it is challenging to manage consistency among them. However, the PSS literature lacks approaches for managing inconsistency among various type of models. This study proposes a framework that supports establishing a systematic solution for inconsistency identification during PSS development.
Nascent Entrepreneurial Teams (NETs): An Insight into Their Composition and Its Effect on Success

The thesis explored nascent entrepreneurial team (NET) composition and its effect on business success. Drawing on team formation theory (i.e. homophily, similarity- attraction paradigm, rational process model, cognitive resource perspective theory), the thesis addressed the composition, typology and effect on future success in nascent entrepreneurial businesses started by teams. To do so, this thesis addresses three research questions: 1) What types of composition are prevalent in NETs? 2) What different team profiles or types can be identified among NETs, based on their compositional dimensions? 3) What effect does NET composition have on nascent entrepreneurial success? NET composition is studied by calculating the degree of diversity and physical proximity within the team. In line with the current literature, four dimensions of NET composition are examined: Demographic Diversity, Human Capital, Resource Heterogeneity, and Familiarity. The research is conducted by using data from the US Panel Study of Entrepreneurial Dynamics II. The dataset provides information on each team member of the NET and records information about the business over a period of five years. This enables examination of NET composition and its effect on the nascent business success. Thus, the units of analysis considered in this thesis are the team for the predictor variables and the firm for the outcome variables. Overall, the quantitative exploratory study revealed that NET composition has an effect on the probability of success as a nascent business, but has no significant impact on the time taken to achieve success The present thesis makes original contributions to the existing body of knowledge on entrepreneurship in three ways. First, this thesis adds to entrepreneurship literature by exploring to what extent team formation theory can be applied in the nascent entrepreneurial context. Second, this thesis considers the effect of team composition on three dimensions of success, which aims to clarify the current debate regarding success measurement when studying nascent entrepreneurial stage. Third, this thesis introduces an innovative way to study NET composition by considering a typological approach, which at the same time adds to the few methodological efforts to use clustering in entrepreneurial research. Lastly, the findings of this thesis have implications for practitioners, advisory bodies, and policy-makers. For practitioners, the conclusions suggest that attention should be given to identify the potential limitations and advantages related to the team composition/configuration. For advisory or consultant bodies, the present results are helpful in designing better support programmes and training courses for NETs. Finally, while this thesis does not explicitly concern itself with entrepreneurial policy, its findings can suggest a number of implications worth of attention in support to entrepreneurial activity.
Canadian Educational Approaches for the Advancement of Pharmacy Practice

Canadian faculties (schools) of pharmacy are actively engaged in the advancement and restructuring of their programs in response to the shift in pharmacy to pharmacists having/assuming an advanced practitioner role. Unfortunately, there is a paucity of evidence outlining optimal strategies for accomplishing this task. This review explores several educational changes proposed in the literature to aid in the advancement of pharmacy education such as program admission requirements, critical-thinking assessment and teaching methods, improvement of course content delivery, value of interprofessional education, advancement of practical experiential education, and mentorship strategies. Collectively, implementation of these improvements to pharmacy education will be crucial in determining the direction the profession will take.
Behavioral Finance

Behavioral finance studies the application of psychology to finance, with a focus on individual-level cognitive biases. I describe here the sources of judgment and decision biases, how they affect trading and market prices, the role of arbitrage and flows of wealth between more rational and less rational investors, how firms exploit inefficient prices and incite misvaluation, and the effects of managerial judgment biases. There is need for more theory and testing of the effects of feelings on financial decisions and aggregate outcomes. Especially, the time has come to move beyond behavioral finance to "social finance", which studies the structure of social interactions, how financial ideas spread and evolve, and how social processes affect financial outcomes.
Baclofen novel gastroretentive extended release gellan gum superporous hydrogel hybrid system: in vitro and in vivo evaluation

Abstract Baclofen is a centrally acting skeletal muscle relaxant with a short elimination half-life, which results in frequent daily dosing and subsequent poor patient compliance. The narrow absorption window of baclofen in the upper gastrointestinal tract limits its formulation as extended release dosage forms. In this study, baclofen extended release superporous hydrogel (SPH) systems, including conventional SPH, SPH composite and SPH hybrid (SPHH), were prepared aiming to increase the residence of baclofen at its absorption window. The applicability of different polymers, namely, gellan gum, guar gum, polyvinyl alcohol and gelatin, was investigated in preparation of SPHH systems. The prepared SPH systems were evaluated regarding weight and volume swelling ratio, porosity, mechanical properties, incorporation efficiency, degree of erosion and drug release. In vivo assessment was performed in dogs to evaluate gastric residence time by X-ray studies. In addition, the oral bioavailability of baclofen relative to commercially available Lioresal® immediate release tablets was also investigated. The novel baclofen gellan SPHH cross linked with calcium chloride was characterized by optimum mechanical properties, acceptable swelling properties as well as extended drug release. It also exhibited a prolonged plasma profile when compared to twice daily administered Lioresal®.
Primary intracerebral and aneurysmal subarachnoid hemorrhage in Izumo City, Japan. Part II: management and surgical outcome.

OBJECT The purpose of this study was to assess the overall management and surgical outcome of primary intracerebral hemorrhage (ICH) and aneurysmal subarachnoid hemorrhage (SAH) among the 85,000 residents of Izumo City, Japan. METHODS During 1991 through 1996, 267 patients with ICH and 123 with SAH were treated in Izumo. Of the 267 patients with ICH, 25 underwent hematoma removal by open craniotomy or suboccipital craniectomy and 34 underwent stereotactic evacuation of the hematoma, whereas aneurysm clipping was performed in 71 of the 123 patients with SAH; operability rates were thus 22% for ICH and 58% for SAH (p < 0.0001). The overall 30-day survival rates were 86% for ICH and 66% for SAH (p < 0.0001) and the 2-year survival rates were 73% and 62% (p = 0.0207), respectively. In patients who underwent surgery, 30-day and 2-year survival rates were 93% for ICH and 100% for SAH (p = 0.0262), and 75% for ICH and 97% for SAH (p = 0.0002), respectively. In patients with ICH, the most important predictors of 30-day case-fatality rates were the volume of the hematoma, the Glasgow Coma Scale (GCS) score, rebleeding, and midline shifting, whereas those for 2-year survival were the GCS score, age, rebleeding, and hematoma volume. In patients with SAH, the most important determinants of 30-day case-fatality rates were the GCS score and age, whereas only the GCS score had a significant impact on 2-year survival. CONCLUSIONS The overall survival rates for patients with ICH or SAH in Izumo were more favorable than those in previously published epidemiological studies. However, despite improved surgical results, the overall management of ICH and SAH still produced an unsatisfactory outcome, mainly because of primary brain damage.
The bioinformatics of next generation sequencing: a meeting report.

scientists after finishing human genome aimed to develop tailor made drugs based on genome information. However, this requires personal genome sequencing, knowledge of genome level SNPs and other variations. More to add, there were some very serious domains of life about which our knowledge remained very limited and full of myths till the arrival of application of next generation sequencing. Metagenomics, Epigenomics, importance of non-coding elements like Alu and microRNAs, reports like high transcriptional activities of retroelements and transposons in plant system, all picking up after the advent of next generation sequencing, just with in the past 5 years or so (Shendure and Ji, 2008). Sensing the relevance and importance of thetopic,SCBB,IHBTplannedanddesigned this workshop to create awareness about NGS and associated Bioinformatics activitiesatthenationallevel.Itcarefullyselected the speakers at national platform and invited specialists in Bioinformatics and NGS. The workshop was designed to benefit the community with first hand personal experiences of each other, discuss, present their work, problems and create awareness. Total eight speakers were invited to deliver a lecture series, give demonstrations, hands-on training and participate in brainstorming session with participants selected from all over India. Most of the selected participants were associated with research problems involving next generation sequencing application. The lecture session was kept open for interested scientists.
Adaptation of rat olfactory bulb neurones.

1. Single‐unit activity was recorded from olfactory bulb neurones driven by odorous stimuli. Neural responses were quantified as averaged peristimulus time histograms. 2. Successive presentations of the same stimulus evoked similar patterns of activity during each presentation. Some neurones exhibited increased and others decreased excitability in the adapted state. The occurrence of such facilitative or suppressive self‐adaptation was not determined by odorant concentration or by the number of action potentials evoked by a given stimulus. Neurones driven by more than one odorant exhibited the same type of adaptation (facilitative or suppressive) for all effective stimuli. 3. When the first odorant differed from the second, the number but not the pattern of action potentials evoked by the second odorant differed from the non‐adapted state. Some neurones exhibited increased and others decreased excitability in the cross‐adaptation state. Neurones exhibiting suppressive self‐adaptation did not exhibit facilitative cross‐adaptation and those exhibiting facilitative self‐adaptation did not exhibit suppressive cross‐adaptation. Instances of asymmetrical cross‐adaptation were noted in which two odorants differed in the extent to which they affected subsequent sensitivity to each other. The degree of symmetry for a given pair of odorants differed for different neurones. It is concluded that neurones in the olfactory bulb differ in both the type (suppressive or facilitative) and extent of adaptation evoked by a given odorant.
Barriers to effective teaching of Computer Studies in selected government junior secondary schools of Mwansabombwe District in Luapula Province

The study aimed at investigating the barriers to the effective implementation of computer studies curriculum in selected junior public secondary schools of Mwansabombwe District (MWD) in Luapula province. The study further sought to establish the availability of ICT infrastructure and equipment in the selected schools. It also sought to establish the effects of teacher training and exposure to ICT on the implementation of computer studies curriculum in M W D . The third objective was to explore the measures that could be put in place to enhance the implementation of computer studies curriculum in the selected schools in M W D . The target population was 15 junior public secondary schools in the District. A descriptive survey design was used. Purposive sampling techniques and simple random sampling techniques were used to select a study sample of 10 schools. Additionally, 34 respondents were captured as follows: 10 headteachers, 20 computer teachers and 4 Education Standards Officers (ESOs). Purposive sampling technique was used to select the 10 headteachers and the 4 ESOs. Purposive sampling technique and simple random sampling technique were used to select the 20 computer studies teachers. A n Interview guide was used to obtain information from the Headteachers and ESOs while questionnaire guide was administered to the teachers. A n Observation Checklist was also used by the researcher. The data collected was analyzed using descriptive statistics and presented in tables, charts and graphs. This study established that only 10% of the schools sampled had implemented computer studies curriculum effectively. Inadequate funds to procure computers, their accessories and set up infrastructures such as computer laboratories, lack of trained computer teachers and inadequate revision materials were found to be the major challenges in the implementation process. Based on the research findings, the researcher recommended that the government should provide grants to schools to procure more computers, their accessories and set up infrastructure such as computer laboratories and enhance the connection of the secondary schools with fibre optic cables to enhance easier internet access. The M O G E should also recruit computer teachers in all public junior secondary schools.
EGFR TKI combination with immunotherapy in non-small cell lung cancer

ABSTRACT Introduction: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) has significantly improved clinical outcomes compared with chemotherapy in non-small cell lung cancer (NSCLC) patients with sensitizing EGFR gene mutation. Areas covered: Almost all patients treated with EGFR TKIs eventually develop acquired resistance. It has been reported that activation of the oncogenic EGFR pathway enhances susceptibility of the lung tumors to PD-1 blockade in mouse model, suggesting combination of PD1 blockade with EGFR TKIs may be a promising therapeutic strategy. Nivolumab combined with erlotinib was associated with 19% of grade 3 toxicities. The combination of osimertinib plus durvalumab in pretreated or chemo naïve NSCLC patients showed encouraging clinical activity, however, this combination was associated with high incidence of interstitial lung disease (38%), leading to termination of further enrollment. The combination of gefitinib plus durvalumab demonstrated encouraging activity but higher incidence of grade 3/4 liver enzyme elevation (40–70%). The treatment related Grade 3–4 adverse events were observed in 39% of patients when treated with atezolizumab plus erlotinib. Expert opinion: Given the relatively high incidence of treatment-related toxicities associated with combination of EGFR TKI and immunotherapy, further development of this approach remains controversial. Until now, the combination of EGFR TKI and immunotherapy should be investigational.
CT angiographic diagnosis of hepatosplenomesenteric trunk â a rare variation

We report an incidental finding of a rare anatomical variation of foregut and midgut arteries, hepatosplenomesenteric trunk on multidetector computed tomography (MDCT) abdominal angiography in a78-year-old male patient. MDCT is a robust and accurate diagnostic modality for the diagnosis and analysis of pathologies and anatomical variations of vessels. Proper understanding of anatomical variations of celiac trunk and superior mesenteric arteries is of prime importance prior to surgical or interventional procedures.
Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment

Several protein families control intracellular transport processes in eukaryotic cells. Here, we show that the Rab11 GTPase effector protein Rab11-FIP3 (henceforth, FIP3) directly interacts with the dynein light intermediate chain 1 (DLIC-1, gene symbol DYNC1LI1) subunit of the cytoplasmic dynein 1 motor protein complex. We show that Rab11a, FIP3 and DLIC-1 form a ternary complex and that DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells. We demonstrate that association between FIP3 and DLIC-1 at the cell periphery precedes minus-end-directed microtubule-based transport, that FIP3 recruits DLIC-1 onto membranes, and that knockdown of DLIC-1 inhibits pericentrosomal accumulation of key endosomal-recycling compartment (ERC) proteins. In addition, we demonstrate that expression of a DLIC-1-binding truncation mutant of FIP3 disrupts the ability of ERC proteins to accumulate pericentrosomally. On the basis of these and other data, we propose that FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport of material from peripheral sorting endosomes to the centrally located ERC.
Adjuvant Arthritis Induced in Germ-Free Rats.∗

Summary The polyarthritis which occurs after injection of water-in-oil adjuvant into laboratory rats was found to develop as readily in the germ-free animal. In addition to the acute arthritis, both groups of animals also developed a florid urethritis and balanitis. In this study repeated cultures of food, feces, urine and urethral discharge were always bacteriologically sterile in the germ-free group. Hence it is apparent that a bacterial flora is not necessary for development of adjuvant arthritis.
Conflicts in a Closely Held Family Business: Durga and Company

The purpose of this case is to investigate the nature of conflicts that arise in a closely held family business (CHFB) and to identify variables that ensure successful transition from one generation to the next. This case necessitates that in order to decide on the inheritance, a three-step process, prevention, management and resolution of conflict, is essential. It also highlights the gender bias in succession planning, ignoring the capabilities and competence of women in the family. Unstructured interviews around multiple stakeholders in the family business (FB) were taken identifying the core issues leading to conflicts. Triangulating with multiple sources or incumbents has reduced biases. It is observed that conflicts are inevitable within CHFBs. However, it is widely accepted that conflicts are paramount to forward progression both for the family and for the business, when it is constructive in nature. The case reflects the importance of understanding the critical issues around family and business. The outcome is useful in relaying better understanding on dimensions of conflicts that plague family-controlled business. Family businesses must relay importance of managing conflicts and bringing in earlier resolutions before they become extinct. The aftermath of not resolving such conflicts can be as catastrophic of destroying the FB and its wealth in the longer run.
Geographic distance and the impact of investor sentiment on stock prices

Geographic Distance and the Impact of Investor Sentiment on Stock Prices by YANG Yan Master of Philosophy Based on China’s stock market, this study investigates how firms’ geographic distance from a financial center affects the sensitivity of stock prices to investor sentiment. I find that firms located closer to a financial center are more affected by investor sentiment than firms located far from a financial center. This distance effect holds for different geographic cutting boundaries and after excluding firms located in financial centers. Besides, using China’s High Speed Railway (HSR) as an exogenous shock, I find that HSR connection significantly decreases the effect of geographic distance on the sentiment-driven stock price relationship. In addition, firms with shorter travel times to financial centers are more affected by investor sentiment than firms with longer travel times. Moreover, firms located in provinces with a high stock market participation rate are more affected by investor sentiment than other firms. And Analysts increase the frequency of favorable recommendations for firms that are located closer to financial centers when investor sentiment is high. Furthermore, firms located closer to a financial center do not have higher institutional ownership than other firms. Last but not least, firms located in more economically developed provinces are not more affected by investor sentiment than firms located in less developed provinces. Overall, my findings highlight the importance of geographic distance in explaining the effects of investor sentiment on stock prices.
Fallbasiertes Schließen zur Kreditwürdigkeitsprüfung

Zusammenfassung In diesem Artikel diskutieren wir Anforderungen aus der Kreditwürdigkeitsprüfung und ihre Erfüllung mit Hilfe der Technik des fallbasierten Schließens. Innerhalb eines allgemeinen Ansatzes zur fallbasierten Systementwicklung wird ein Lernverfahren zur Optimierung von Entscheidungskosten ausführlich beschrieben. Dieses Verfahren wird, auf der Basis realer Kundendaten, mit dem fallbasierten Entwicklungswerkzeug INRECA empirisch bewertet. Die Voraussetzungen für den Einsatz fallbasierter Systeme zur Kreditwürdigkeitsprüfung werden abschließend dargestellt und ihre Nützlichkeit diskutiert.
Effective Whistle-Blowing Mechanisms in the Public Sector

The objective of this paper is to investigate effective whistle-blowing mechanisms in the public sector. The study adopted descriptive survey research design. It collected data from both primary and secondary sources. A total of 700 questionnaires were administered out of which 672 were retrieved. These were used for analysis, employing simple random technique together with simple frequency table, Pearson’s correlation coefficient and descriptive statistics. The findings of the study show that: there is a significant relationship between whistle blowing mechanism and performance in the public sector and internal whistle-blowing mechanisms should be encouraged. The study recommends that those who are charged with responsibility in public sector should promote the system, procedures and culture of whistle blowing mechanisms, and strengthen internal reporting mechanism. This would enhance government to achieve her mission and objectives. The study concludes that whistle blowing mechanisms should be encouraged and relevant Acts should be applied judiciously.