Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of combined treatment of amiodarone and vitamin U on rat gingiva

Amiodarone, the pharmaceutical drug used for the treatment of arrhythmias, is known to cause many side effects. S-Methylmethionine sulfonium is a derivative of methionine and it is widely referred to as vitamin U (Vit U). In the peer-reviewed literature, there is no study reported on the protective effects of Vit U against amiodarone’s side effects on gingiva. In this study, we investigated the oxidative and inflammatory effect of amiodarone or putative protective role of Vit U on gingiva tissue. Rats were randomly divided into four groups as follows: control group: rats received corn oil; control+Vit U treated group (50 mg/kg/day); amiodarone group (100 mg/kg/day) and amiodarone+Vit U treated group (in same dose). Amiodarone and Vit U were given orally for 7 days. Vit U was given 1 h prior to the administration of amiodarone. Gingival tissues were taken from animals and homogenized in 0.9% NaCl. Lipid peroxidation and sialic acid levels were increased significantly, glutathione levels and superoxide dismutase activities were decreased significantly in the amiodarone group when compared with the control groups. Vit U combination with amiodarone reversed these effects. These results demonstrate that administration of Vit U may have protective effects on gingiva in amiodarone treatment by decreasing oxidative stress.
NURSING CONTRIBUTIONS TO SMOKING CESSATION

Healthcare especially nursing contributions to smoking cessation is one of the top priorities of developing societies and the Finnish government with regards to health of the people. The aim and objectives of the study was to investigate health strategies are compliant with WHO guidelines and understand behavior modification through a nursing theory which could be used for further research. This was guided by the research questions; what are the nursing strategies in smoking cessation and how can they be incorporated in a theoretical framework plan? Finland-based English-written articles on the topic were few, however the study was graced by a rich variety of relevant articles gotten from databases like Cochrane library, Academic Search Elite EBSCO host and CINAHL. The results of literature review focused on articles which examined pharmacological interventions (Nicotine Replacement Therapy, medication and combination treatments), non-pharmacological interventions (quit-lines, behavioral support, and motivation), and nurses and other healthcare providers’ intervention. Self-motivation, willingness, and empowerment from both the healthcare provider and the client could enhance implementation of interventions by using Pender’s health promotion model, leading to positive behavior outcomes. Conclusion of the study reveals smoking cessation intervention strategies are effective incompliance with World Health Organization’s recommendations and subsequent implementation by nurses in the Health sector. The smoke-free Finland deadline is apparent more research needs to be done, to this light a long list of references provided may offer great help.
Factors That Promote Autonomous and Controlled Motivation in Self-management Behavior of Hemodialysis Patients

This study examined the differences and primary factors from the impact of autonomous motivation and controlled motivation on the self-management behavior of hemodialysis patients. Anonymous, self-describing questionnaires were used for research on nine different dialysis facilities of 413 people who regularly visit. From using the primary factor results of multiple regression analysis, that took autonomous motivation and controlled motivation as the dependent variable, a path diagram was created that led to each motivation. The acknowledgement of autonomy support facilitated whether it was autonomous motivation or controlled motivation (The standardized coefficient was 0.385, 0.346, p < 0.0001). Positive evaluation coping skills were a primary factor that promoted autonomous motivation, while trait anxiety, disorders of social activities, and lack of motivation were primary factors that promoted controlled motivation. In order to raise the autonomous motivation to promote self-management behavior in patients with hemodialysis treatment, situations that easily cause amotivation and anxiety, as well as tendencies for depression should be assessed. Also the encouragement to attain positive evaluation coping skills to support patient autonomy appears to be effective.
The effects of energy drinks, drugs and hormones that taken by the bodybuilding sportsmen on the some liver and kidneys functions in Kirkuk city

The present study included one hundred ten volunteers (bodybuilding sportsmen; Ninety sportsmen took stimulants and twenty without stimulants). Then, volunteers distributed to four groups according to the types of stimulant. The first group was control group without stimulants. The second group sportsmen who used energy drinks (Red bull and Power Horse). The third group sportsmen who used drugs (max miz (100mg), XXL protein (100mg)، sirios mass (200mg). The fourth group sportsmen who used hormones(testosterone، insulin، growth hormone، nandrolone، primobolan and stanazol). The results showed significant increased (P<0.05) in serum aspartate transaminase (AST), alanine transaminase (ALT), cholesterol, triglyceride, urea, creatinine, potassium and decreased sodium in all groups who consumed energy drinks, drugs and hormones compared with control groups. The aim of this study was to investigate some biochemical parameters included AST, ALT, cholesterol, triglyceride, urea, creatinine, potassium and sodium concentrations in sera of all bodybuilding sportsmen. Conclusions: concluded from this study that the stimulants which used by bodybuilding sportsmen have risk effects on the liver and kidneys functions.
Successful application of laparoscopic techniques in colorectal surgery and its indications

Laparoscopic surgery is now widely used for a variety of indications, including both benign and malignant disease in colorectal surgery. There has been an increase in utilization of laparoscopy to treat colorectal pathology over the past decade. This adoption is likely related to the increased comfort among surgeons for laparoscopic surgery, and a growing body of literature that shows equivalent, if not superior, outcomes to open surgery. Many of the same safe practices that are used in open surgery can be applied laparoscopically as well. However, new issues and opportunities for improvement have come along with minimally invasive techniques. While abdominal entry was initially solely based on the location of the surgical target organ, we are now faced with choices regarding the initial entry into the abdomen and creation of pneumoperitoneum. It has also opened the door for early recovery protocols as a large incision is no longer a major determinant of hospital stay. We are also faced with an ever-growing list of indications and novel applications. As surgeons become more facile and instruments become more advanced, approaching emergent indications laparoscopically and avoiding open surgery should become standard of care. However, all of this progress relies on safe techniques, technical expertise and appropriate patient selection.
Microenvironment regulation of pluripotent stem cell-derived neural progenitor aggregates by human mesenchymal stem cell secretome.

Neural progenitor cells (NPCs) derived from pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced PSCs, are promising cell source for the treatment of various neurological diseases. NPC derivation from PSCs is regulated by microenvironment factors that influence cell fate via paracrine and autocrine effects. In this study, ESC-derived NPC aggregates were replated in the secretomes of bone marrow-derived human mesenchymal stem cells (hMSCs) generated under hypoxia or normoxia to investigate the effects of hMSC secretome on NPC cellular behaviors. The results demonstrated that hMSC secretomes stimulated endogenous secretion of extracellular matrices from NPC aggregates and enhanced cell adhesion and proliferation. NPC functional differentiation measured by migration length, neurite extension, and the yield of neural and glial cells were also increased by threefold to fourfold. Inhibition of fibroblast growth factor-2, transforming growth factor-β1, and brain-derived neurotrophic f.
AB0035 A physiological network of igg autoantibodies targeting g protein coupled receptors

Background Since the time when Paul Ehrlich conceived the term “horror autotoxicus”, autoantibodies have been associated with the development of autoimmune diseases. However, several works have recently shown the presence of autoantibodies in sera from healthy subjects (n=489), who do not develop autoimmune diseases. Objectives Here, we report a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCRs), growth factors and growth factor-related molecules in sera from healthy subjects. Methods Autoantibody levels in sera were assessed using ELISA. Autoantibody network was analysed by exploratory factor analysis (EFA), dandelion plot method, hierarchical clustering, and multi-study factor analysis (MFA). We also reverse engineered autoantibody functions through in silico evaluation of autoantibody target interactions using STRING and gene ontology (GO). To test the autoantibodies functionality we assessed the in vitro production of IL-8 by PBMCs and neutrophil migration in response to IgG from healthy subjects as well as ETAR-immunised and control mice. Leukocyte cellularity to secondary immune organs was analysed comparing ETAR-immunised with control mice. Results Gender, age and the presence of pathological conditions (systemic sclerosis n=84, Alzheimer’s disease n=91 and ovarian cancer n=207) changed correlations between the autoantibodies and their hierarchical clustering distribution. Notably, subjects at age below and above 65 years or with pathological conditions exhibited particular autoantibody hierarchical clustering signatures. In addition, females at age above 65 years, representing the group of subjects with higher risk to develop SSc, displayed the closest link to SSc in terms of autoantibody hierarchical clustering. Finally, autoantibody directed against the endothelin receptor type A (ETAR) showed an essential role in the autoantibody network by orchestrating neutrophil trafficking in vitro and in ETAR-immunised mice. Conclusions Our data provide a framework for the existence of a physiological network of autoantibodies and reveal a new paradigmatic view on these physiological molecules. Disclosure of Interest None declared
Etude de la résistance de Cupriavidus metallidurans CH34 aux oxyanions sélénite et séléniate : accumulation, localisation et transformation du sélénium.

Le selenium est un element trace essentiel pour les organismes vivants mais a forte concentration, il est tres toxique. Les oxyanions selenite et seleniate sont les formes les plus toxiques et predominantes dans l'environnement. Certains micro-organismes jouent un role preponderant en contribuant au cycle naturel du selenium. Notre modele d'etude Cupriavidus (anciennement Ralstonia) metallidurans CH34, bacterie tellurique issue de biotopes contamines en metaux, est connu pour resister au selenite (forme soluble du selenium, tres toxique et bio-assimilable) en le reduisant en selenium elementaire (forme precipitee insoluble et peu toxique). Afin de mieux comprendre les mecanismes de reduction du selenium par les bacteries, trois methodes de speciation ont ete combinees (SAX (XANES et EXAFS), HPLC-ICP-MS et SDS-PAGE-PIXE) et normalisees par la quantification du selenium accumule dans les bacteries. Les analyses de speciation ont mis en evidence l'existence de deux voies de reduction du selenium chez C. metallidurans CH34 : une voie d'assimilation transforme le selenite et le seleniate en selenium organique, identifie comme de la selenomethionine et conduit a son incorporation dans des proteines bacteriennes. L'espece organique selenomethionine semble etre incorporee dans les proteines de facon non specifique (presence de proteines seleniees). Une voie de detoxication precipite le selenite en nanoparticules de selenium elementaire. Cette voie de detoxication ne se met pas en place apres une exposition au seleniate malgre sa presence comme espece minoritaire par rapport a l'exposition selenite. Du selenodiglutathion est detecte dans des bacteries stressees par une exposition au seleniate en milieu limite en sulfate. Les bacteries exposees a du selenite accumulent 25 fois plus de selenium que lorsqu'elles sont exposees a du seleniate. L'etude de mutants resistants au selenite, n'exprimant pas la proteine membranaire DedA, a montre que l'accumulation du selenium apres exposition au selenite est diminuee compare a la souche sauvage signifiant un probable lien entre la prise en charge du selenite et la proteine DedA. Enfin, le seleniate semble emprunter la sulfate permease de C. metallidurans CH34.
Different patterns of uptake and depuration of cadmium by periphyton community and a grazer species ( Physa sp.): A mesocosm evalution

Widespread pollution by heavy metals generated by various industries has serious adverse effects on human health and the environment. Cadmium is a heavy metal recognised as one of the most hazardous environmental pollutants (Lodeiro et al. 2005). It is a non-essential and non-beneficial element to organisms, causing toxicity and other deleterious effects on various components of the aquatic environment. The ability of algal periphyton to concentrate cadmium from fresh water is well known (Hill et al. 2000). Moreover, periphyton communities are able to accumulate large amounts of cadmium despite its low concentration in fresh water. Cadmium bioaccumulation has been studied in bacteria (Trevors et al. 1986; Volesky & Holan 1995), Cyanobacteria (Les & Walker 1984; Inthorn et al. 1996), algae (Sakaguchi et al. 1979; Geisweid & Urbach 1983; Holan & Volesky 1995) and fungi (Fourest & Roux 1992; Holan & Volesky 1995). Periphyton algae, bacteria, and fungi that develop on stream substrata, can accumulate high concentrations of metals and may be an important source of metal exposure to benthic macroinvertebrates in mining-impacted streams (Kiffney & Clements 1993).
Characterization of neuroligin 4, a protein involved in autism spectrum disorders

Neuroligins (NLs) are ubiquitous postsynaptic adhesion proteins that are essential for synaptic maturation and function. Of the four NL isoforms expressed in the central nervous system (CNS), NL4 is of particular interest since loss-of-function mutations of NL4 have been associated with autism-related disorders in humans (Jamain et al., 2003). Furthermore, NL4 knockout mice were found to show specific behavioral phenotypes that mimic those observed in autism (Jamain et al., 2008). In the present study, the distribution of NL4 protein was characterized in the mouse central nervous system (CNS) using a NL4 specific antibody. The highest NL4 protein expression levels were observed in brainstem, spinal cord and globus pallidus. At the synaptic level, NL4 is localized to a majority of inhibitory postsynapses in the globus pallidus, brainstem and spinal cord, and to glycinergic synapses in the brainstem and spinal cord (Hoon et al., 2011). Interestingly, NL4 is not exclusively restricted to inhibitory postsynapses in the forebrain. In the hippocampus, NL4 equips both inhibitory and excitatory synapse types, whereas in the barrel cortex NL4 seems to be preferentially associated with excitatory synapses. In order to study the role of NL4 at synapses, the consequences of NL4 deletion on synapse number was examined. In the barrel cortex and hippocampus, the loss of NL4 did not influence the density of excitatory or inhibitory synapses. Similarly, no differences were observed in the number of glycinergic synapses in the spinal cord. The absence of an effect of NL4-loss on the number of synapses in the CNS could potentially be explained by a compensatory effect of one of the other NL isoforms. In line with this hypothesis, an upregulation of NL2 and NL3 levels was observed in the somatosensory cortex of the NL4- KO mice. Interestingly, in the absence of NL4, the power of kainate-induced gamma oscillations in area CA3 of the hippocampus was found to be substantially reduced. This phenotype indicates a defect in the synaptic network between pyramidal cells and inhibitory interneurons in the hippocampus. Together, these data provide new insights into the physiological consequences of NL4 loss in autism spectrum disorders, which may lead to an imbalance of excitatory and inhibitory synaptic transmission in various brains regions, including the hippocampus.
Self-Care Education Effect on Patient Quality of Life with Phenyl Ketone Urea in Medical Center in Tehran, Iran

Chronic diseases are common health problems around the world. Although health behavior habits are affected by the incidence and severity of them. Phenyl ketone urea disease is an autosomal recessive disorder with enzymatic deficiency that causes these patients to be at risk by developing mental disorders. This study attempts to investigate the effect of self-care education on the quality of life of phenyl ketone urea in Tehran Children Medical Center in order to improve the quality of life in the country. This study is cross-sectional and interventional, in which patients between 7 to 35 years old were 99. Data collection tool was a standard questionnaire of quality of life with 36 questions including 9 quality of life components. For data analysis, T-Test and linear regression were used. In the control group, the mean change in quality of life and the study group were 37.99 ± 13.21 and 55.64 ± 5.57 respectively (p <0.001), and the results showed a significant correlation between self-care education and quality of life. According to the heritability of the Phenyl Ketone Urea disease as well as lack of control of physical and mental health disorders that cause illness, continuing education programs could lead to a dramatic reduction in behavioral disorders. Self-care education can be designed to comply with the patient which plays an important role in improving the quality of life and level of public health of society.
Utilization possibilities of jellyfish Rhizostoma pulmo, as a food in the Black Sea

sto Jellyfish, Rhizostoma pulmo, from the Black Sea were processed according to Maruichi and Wootton processing methods and stored at - 4°C for two different periods, i.e., 1 and 24 months. Moisture, ash and protein values were determined. In addition, the levels of calcium, magnesium, copper, iron, zinc and nickel were determined in the salted jellyfish. Since the ash and protein contents were determined after removing the excess salt and alum from dried samples, the values appeared to be quite different from those previously reported. In conclusion, both the processing methods as well as the storage periods were found to be effective in giving acceptable products. La meduse Rhizostoma pulmo pechee dans la mer noire est transformee d'apres les methodes de Maruichi et Wootton (salage et sechage) et entreposee a 4° pendant 1 et 24 mois. Sa composition est determinee. Les teneurs en calcium, magnesium, cuivre, fer, zinc, et nickel sont dosees. Cette methode de preparation et la duree d'entreposage donnent un produit acceptable pour la consommation.
Estudios cromosómicos de cuatro selecciones de Capsicum chinense Jacq.

La coleccion del germoplasma se realizo en la Estacion Horticola Campo Universitario, Jusepin, Estado Monagas. Las observaciones se realizaron en celulas meristematicasradiculares de Capsicum chinense . La metodologia utilizada fue colchicina al 0,05% durante dos a tres horas, cloruro de sodio al 0,03% por 10 a 20 minutos y alcohol etilico y acido acetico glacial en una relacion 3:1, la clasificacion cromosomica se realizo utilizando la metodologia de Levan et al. (1964). Los cromosomas y los cariotipos de las cuatro selecciones estudiadas, mostraron 2n = 24. Los cariotipos de las selecciones tienden a ser simetricos. Las formulas cariotipicas varian entre las selecciones estudiadas y se proponen las siguientes: Seleccion 3: 11m + 1sm; Seleccion 4: 11m + 1st; Seleccion 5: 1M + 9m + 2sm y para la Seleccion 6: 11m + 1st.
Structural characterization of multiphase emulsion systems based on an alkylpolyglucosode non-ionic emulsifier

The aim of this study Was to Examine the lyotropic potential of an alkylpolyglucoside mixed Emulsifier (Cetearyl Glucoside & Cetearyl alcohol), Which Belongs to the new generation of natural (sugar) surfactants, and to elaborate the stabilization mechanism and relation Between the colloid microstructure and water distribution Within the systems. Polarization and ordinary light as well as transmission electron microscopy, wide angle X-ray diffraction, thermal analysis and rheological measurement, as well as in vivo hydration potential Were employed for testing the systems Characterization. A comparison of results Obtained from Isothermal thermogravimetry and in vivo short-term application study served to Recognize Within water distribution systems and the dynamic of water evaporation, ie to consider in the Possibility of Formulation and Prolonged water emulsion with controlled release. It Was Suggested That Cetearyl glucoside & Cetearyl alcohol stabilizes the o / w creams by synergistic effects of Viscoelastic Hydrophilic Lamellar type of gel and lipophilic gel network built up from semi-Cetostearyl alcohol hydrates as well as by Lamellar liquid crystalline bilayers surrounding the oil droplets. Generally, in creams based on the non-ionic Emulsifier alkylpolyglucoside MontanovO 68 PHA four fractions of water Could Be Met: 1) free - bulk water, 2) Within lipophilic gel bonded water (secondary water), 3) water interlamelarilly Between fixed crystalline lipid bilayers (Hydrophilic gel) and 4) water Between fixed lipid layers in liquid-crystalline state. It is Also Showed That Additions oil into The Chosen binary system microstructure Significantly Influences the creams, Which Reflects Particularly onto the mode of water distribution and consequently Their creams Within The potential of skin hydration. Thus, the model with Emulsifier cream / water ratio of 1:10:43 and 20% medium chain triglycerides as oil phase Was selected as optimal model Formulation with Prolonged pronounced potential for skin hydration.
Numerical anomalies of teeth observed in a reared Malayan tapir (Tapirus indicus

（Abstract） Numerical anomalies of teeth were observed in the left lower jaw of a male Malayan tapir (Tapirus indicus specimen reared in Nagoya Higashiyama Zoo. The absence of I3 was found in it. The dental alveolus of this tooth was not observed by both direct and radiographic examinations. Moreover no trace of repairing such as tuberosity and trace of alveoli was found on the surface of the mandible. These facts suggest that the absence of I3 occurred congenitally. Two teeth were observed side by side at the locus of the lower second premolar of this mandible. The lingual one is regarded as P2 and the buccal one is regarded as a“supernumerary tooth” ．This“supernumerary tooth”closely resembled P2 in shape but was somewhat smaller than P2 in size. Based on its form size and locus of eruption the“supernumerary tooth” seems to be either the tooth originated from abnormal splitting of the tooth germ of P2 or a persisted dP2.