Miracle-dz/UniFAR-FTUs huggingface dataset:
E2F target genes and cell‐cycle checkpoint control

In this review, we will focus on the role played by transcription factors of the E2F/DP family in controlling the expression of genes that carry out important cell‐cycle control functions, thereby ensuring ordered progression through the mammalian cell division cycle. The emerging picture is that cell‐cycle progression depends on the execution of a regulatory cascade of gene expression, driven by E2F/DP transcription factors, which are in turn regulated by the products of some of these genes. That E2F factors are potent regulators of cell‐cycle checkpoints in mammalian cells is supported by experiments demonstrating that ectopic expression of individual E2F family members is sufficient to modulate cell proliferation and apoptosis. It is also clear that deregulation of E2F activity will result in the loss of particular checkpoint controls, thereby predisposing cells to malignant conversion. BioEssays 21:221–230. 1999. © 1999 John Wiley & Sons, Inc.
Price formation on the EuroMTS platform DIW

This paper examines the process of price discovery in the MTS system, which builds on the parallel quoting of euro-denominated government securities on a number of (relatively large) domestic markets and on a (relatively small) European marketplace (EuroMTS). Using twenty-seven months of daily data for 107 pairs of bonds, we present unambiguous evidence that trades on EuroMTS have a sizeable informational content.
Using focus groups to develop interventions to promote colorectal cancer screening among Vietnamese Americans.

BACKGROUND Colorectal cancer is the third most common cancer in Vietnamese Americans. Their colorectal screening rates are lower than the rates of whites. METHODS Four focus groups were conducted to identify Vietnamese American sources and credibility of health information, media utilization, and intervention approaches. RESULTS Vietnamese Americans trusted doctors and patient testimonials and had access to, and received most of their health information from, Vietnamese- language print and electronic media. Recommended intervention approaches include promoting doctors' recommendation of screening and using Vietnamese-language mass media, print materials, and oral presentations. CONCLUSIONS Focus groups are useful in determining communication channels and intervention approaches.
OS DESAFIOS NA FORMAÇÃO DO PROFISSIONAL DA HOTELARIA FRENTE ÀS ATUAIS NECESSIDADES DO MERCADO DE TRABALHO: A REALIDADE DA HOTELARIA EM NATAL/RN

A sociedade pos-industrial e caracterizada pela economia de servicos. Esse setor esta em crescimento, acompanhando o acelerado desenvolvimento do setor de turismo, no Brasil e no mundo. Tais afirmativas explicitam a fundamental importância que o profissional da hotelaria tem para a sobrevivencia e o crescimento sustentavel do segmento hoteleiro. Sob a luz dessa tematica, este trabalho objetivou investigar se a matriz curricular do Curso Tecnologico em Hotelaria de um Centro Universitario localizado em Natal/RN e se as habilidades desenvolvidas nos egressos estao em congruencia com as necessidades do mercado de trabalho. A analise se desenvolveu por meio de uma pesquisa exploratoria, com abordagem qualitativa, com entrevistas presenciais semi-estruturadas com gestores do mercado hoteleiro da cidade de Natal/RN. Os resultados mostraram que as competencias e habilidades mais citadas pelos entrevistados para o profissional da hotelaria sao: a disponibilidade para servir e o dominio de idiomas. Por outro lado, as funcoes que os egressos estariam aptos a desempenhar, destacam-se funcoes de base nas areas operacionais, para que eles assimilem nocoes praticas sobre as atividades rotineiras do hotel. Embora o curriculo e o Plano Politico Pedagogico do curso de Hotelaria em questao estejam de acordo com as especificacoes das DCNs, o aluno egresso nao esta sendo absorvido pelo mercado hoteleiro de Natal/RN. Isso se deve principalmente pela falta de conhecimento pratico desse aluno acerca das rotinas e peculiaridades desse mercado. Normal 0 21 false false false PT-BR X-NONE X-NONE
Pitting binding against selection – electrophysiological measures of feature‐based attention are attenuated by Gestalt object grouping

Humans have limited cognitive resources to process the nearly limitless information available in the environment. Endogenous, or ‘top‐down’, selective attention to basic visual features such as color or motion is a common strategy for biasing resources in favor of the most relevant information sources in a given context. Opposing this top‐down separation of features is a ‘bottom‐up’ tendency to integrate, or bind, the various features that constitute objects. We pitted these two processes against each other in an electrophysiological experiment to test if top‐down selective attention can overcome constitutive binding processes. Our results demonstrate that bottom‐up binding processes can dominate top‐down feature‐based attention even when explicitly detrimental to task performance.
Verifying networks with symbolic execution and temporal logic

1 VERIFYING NETWORKS WITH SYMBOLIC EXECUTION Symbolic execution is a promising approach to network veri cation [5, 6]. Inspired from software veri cation where it is mainly used to generate test-cases (e.g. [1]), symbolic execution is a technique for exploring all viable execution paths of a program. Symbolic execution runs programs with symbolic inputs instead of concrete ones. Such an input models all possible values in it’s range. When executing conditional instructions, program execution is branched. In the case of an if statement, both the then and the else branches of the program will be explored, and the condition (resp. its complement) will be added as a constraint on each execution path. Adding constraints to a symbolic variable will restrict the values in its range. Constraints are added during branching as well as when executing other non-branching instructions (e.g. assignment). If constraints are unsatis able on a program branch, execution stops on that branch. The output of symbolic execution consists of all satis ed execution branches and for each branch — the set of constraints on each variable. To deploy symbolic execution for verifying networks, the topology is interpreted as a single program whose input is a symbolic packet (i.e. a packet having possibly symbolic header elds). The execution paths of such a program correspond to the set of all possible paths the packet may take through the network. Symnet [6] takes on this approach. Symnet is a symbolic execution engine which runs on SEFL (Symbolic Execution Friendly Language) programs. SEFL is a minimalist imperative language speci cally designed for: (i) modelling network processing and (ii) fast symbolic execution. To verify a network topology, each of its components (and the topology itself) are translated to SEFL code. Symnet is fast and can check large-scale networks (e.g. the Stanford backbone) in seconds.
TOXINA BOTULÍNICA E SUA APLICAÇÃO NA ODONTOLOGIA

A toxina botulinica e muito conhecida por sua utilizacao na medicina estetica, aplicada por meio de injecoes intramusculares para a diminuicao de sinais de envelhecimento, entende-se que sua principal utilizacao diz respeito ao uso da mesma em propriedades terapeuticas. O objetivo geral deste estudo foi fazer uma analise acerca da toxina botulinica e sua aplicacao na odontologia. A metodologia aqui utilizada foi a de revisao de literatura, onde buscou-se por meio de livros e artigos de diversos autores responder ao objetivo principal aqui proposto. Conclui-se que, como o cirurgiao-dentista possui conhecimento sobre as estruturas de cabeca e pescoco, pode e deve tratar patologias da face e cavidade oral de forma conservadora e segura com a aplicacao da toxina botulinica, desde que possua treinamento especifico e conhecimento sobre sua utilizacao. PALAVRAS CHAVE: Ttoxina butolinica. Aplicacao na odontologia. Cirurgiao-dentista.
Implementation of a hardware branch-predictor evaluation platform based on FPGAs

Branch prediction is an important topic in modern Computer Architecture research. Predictors attempt to improve the performance of a processor with a reasonable HW cost. In the last decade, many prediction schemes have been developed in order to achieve this objective, each of them with different cost/performance trade-offs. Identifying the optimal predictor for a given architecture and set of applications is an important issue that involves carrying out extensive simulations. Normally this exploration is carried out using SW emulation tools. However, this approach provides very slow simulation speeds, making it unfeasible for large design-space explorations. In this context, our work presents an important contribution, since we have developed a HW platform, based on FPGAs, for evaluating branch predictors. This platform allows us to evaluate in parallel representative branch prediction schemes, while executing the benchmarks in a SPARC v8 processor implemented in the FPGA. Our approach is several orders of magnitude faster than traditional SWbased approaches, and it not only provides accurate performance statistics but also reports the area cost and the maximum operating frequency of each predictor. In addition, our platform can be easily extended for other processor architectures as long as its HDL codes are available.
KETAMINE: A POTENTIAL RAPID‐ACTING ANTISUICIDAL AGENT?

Ketamine has attracted widespread attention as a potential rapid‐acting antidepressant. There is also considerable interest in its use for the rapid treatment of patients deemed at risk for suicide. Here, we review the available evidence (open‐label and randomized controlled trials) that examine the effects of ketamine on suicidal ideation (SI). Overall, data suggest that ketamine has a rapid albeit transient effect in reducing SI, though some studies had mixed results at different time points or using different assessments. Weaknesses to the existing literature include the small sample sizes of the studies, the exclusion of patients with significant SI at baseline from many of the studies, and the potential functional unblinding when participants are randomized to saline as placebo. The evidence supporting the clinical use of ketamine for SI is very preliminary. Although ketamine appears to a promising therapeutic option in a context where there is a great unmet need (i.e., patients at imminent risk of suicide), further controlled trials are needed to allow for meaningful clinical recommendations.
Siglec-5 (CD170) Can Mediate Inhibitory Signaling in the Absence of Immunoreceptor Tyrosine-based Inhibitory Motif Phosphorylation*

Siglec-5 (CD170) is a member of the recently described human CD33-related siglec subgroup of sialic acid binding Ig-like lectins and is expressed on myeloid cells of the hemopoietic system. Similar to other CD33-related siglecs, Siglec-5 contains two tyrosine-based motifs in its cytoplasmic tail implicated in signaling functions. To investigate the role of these motifs in Siglec-5-dependent signaling, we used transfected rat basophil leukemia cells as a model system. Tyrosine phosphorylation of Siglec-5 led to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, as seen in both pull-down assays and microscopy. Siglec-5 could efficiently inhibit FcϵRI-mediated calcium fluxing and serotonin release after co-cross-linking. Surprisingly, a double tyrosine to alanine mutant of Siglec-5 could still mediate strong inhibition of serotonin release in the absence of detectable tyrosine phosphorylation, whereas a double tyrosine to phenylalanine mutant lost all inhibitory activity. In comparison, suppression of Siglec-5-dependent adhesion to red blood cells was reversed by either tyrosine to alanine or tyrosine to phenylalanine mutations of the membrane proximal tyrosine-based motif. Using an in vitro phosphatase assay with synthetic and recombinant forms of the cytoplasmic tail, it was shown that a double alanine mutant of Siglec-5 had weak, but significant SHP-1 activating properties similar to those of wild type, non-phosphorylated cytoplasmic tail, whereas a double phenylalanine mutant was inactive. These findings establish that Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation.
STRUCTURAL STUDIES ON LNA QUADRUPLEXES

LNAs (locked nucleic acids) are new DNA analogues with higher binding affinities toward nucleic acids than the canonical counterparts mainly due to the characteristic conformational restriction arising from the 2′-O, 4′-C methylene bridge. In light of the promising therapeutic applications and considering the advantageous characteristics of LNAs, such as their high water solubility, easy handling, and synthetic accessibility through the conventional phosphoramidite chemistry, we undertook a study concerning the capability of these nucleic acid analogues to form quadruplex structures. Particularly, we have been investigating the LNA/DNA chimeras corresponding to the well-known DNA sequences 5′-GGTTGGTGTGGTTGG-3′, capable of forming an unimolecular quadruplex. This article deals with the study of the sequence 5′-ggTTggTGTggTTgg-3′ (upper and lower case letters represent DNA and LNA residues, respectively), which, according to CD spectroscopy, is able to fold into a quadruplex structure.
Employer‐Based Coverage and Medical Travel Options: Lessons for Healthcare Managers

EXECUTIVE SUMMARY Outbound medical travel (MT) involves U.S. patients going abroad to seek medical care. Over the past decade, there has been much discussion about MT's broadening appeal to several segments of U.S. healthcare consumers, but little is known about its penetration in the employer‐based coverage (EBC) marketplace. The objectives of this article are to fill this gap and identify (1) the current status of MT options in EBC, (2) the differences between adopters and nonadopters of MT options, and (3) the factors that impede adoption. The results were obtained from a nationwide survey of human resources (HR) professionals making decisions regarding medical benefits. In this sample (n = 608), 16.8% of the respondents offered outbound MT options to their employees, often bypassing their insurance providers. Besides benefiting from a strong HR function, these organizations tended to be more involved in global business transactions, more open to change, more sensitive to cost savings, and more flexible in implementing administrative innovations than nonadopters were. An organizational climate conducive to innovation may explain their propensity to downplay the importance of well‐known obstacles to implementation, such as the effort required to make changes, an emphasis on short‐term goals, and the fear of liability. The lessons to be learned by U.S. healthcare managers are clear. To attract a value‐conscious market, they must offer an attractive package of outstanding quality (clinical outcomes and patient experience) at competitive costs. Operational excellence may thus be the key to slowing the inevitable diffusion of MT options in EBC and maintaining or even expanding the U.S. market share of elective surgeries.
Emotion detection using perceptual based speech features

Speech is one of the most popular modalities for emotion recognition. This work uses Mel and Bark scale dependent perceptual auditory features for recognizing seven emotions from Berlin speech corpus. A combination of Mel Frequency Cepstral Coefficients (MFCC's), Perceptual Linear Predictive Cepstrum (PLPC), Mel Frequency Perceptual Linear Predictive Cepstrum (MFPLPC) and Linear predictive coefficients (LPC) are chosen for the task. The role of perceptual based features is analyzed for effective Speech Emotion Recognition (SER). A search for a compact feature vector of perceptual features is carried out in the discrete and continuous emotion category. Neural network classifier is employed for classification. Comparative analysis with literature shows that the proposed algorithm outperforms in terms of recognition accuracy. Promising results are obtained with the mentioned combination of features in discrete emotional category as well as in arousal dimension of the continuous emotion circumflex.
New Methods of Morphometric Analyses on Scyphozoan Jellyfish Statoliths Including the first Direct Evidence for Statolith Growth Using Calcein as a Fluorescent Marker

Abstract Statoliths are the only hard structures in the gelatinous bell of most scyphozoan medusae and investigations on these structures could promote investigations of the understudied population dynamics and phylogeny of jellyfish. We examined the statoliths of Aurelia aurita jellyfish of different ages by light microscopic and microtomographic measurements supplemented by scanning electron microscopy. The morphometric analyses confirmed that statolith numbers and sizes increase during jellyfish development and revealed that newly-formed statoliths had similar shapes that may change during statolith growth. Nevertheless, most statoliths had a typical compact rod shape with an aspect ratio of 1–2.5 at all ages and we suggest that the composition of statolith shapes may be taxa specific. We developed a new approach allowing exact measurements of statolith growth for the first time. The application of calcein as a fluorescent marker resulted in clear fluorescent lines within the statoliths, allowing calculations of the statolith side face growth increments (0.1 µm/day; n=252). A single-crystal analysis revealed that the calcein incubation did not affect the statolith crystal structure. In conclusion, calcein labeling is an excellent method to follow the growth of bassanite statoliths.
Leptin Receptor and Leukemia

The receptor for leptin, the gene product of the obese gene, is expressed in hematopoietic stem cells. Leptin stimulates normal myeloid and erythroid development, and is secreted from bone marrow adipocytes, which occupy most of the marrow cavity in humans. Leptin might thus play an important role in the control of the expansion and differentiation of primitive hematopoietic cells through paracrine interaction in the bone marrow microenvironment. Leukemic cells of some patients with acute myeloblastic leukemia, acute lymphoblastic leukemia, and chronic myeloid leukemia (CML) also express the leptin receptor. In cases of CML, higher expression of leptin receptor is observed during blast crisis than in chronic phase. Leptin alone and in combination with other cytokines has stimulative effects on proliferation of leukemia cells as well as anti-apoptotic effects. These findings suggest the possibility that leptin plays roles in the pathophysiology of leukemia.
Estrés y deporte de alto rendimiento

Obra sobre psicologia deportiva, cuyo autor expone la aplicacion de principios teoricos y propone tecnicas para una mejor comprension del deportista que es sometido a presiones competitivas, ademas de ofrecer recursos practicos para manejar el estres y optimizar el rendimiento deportivo.
Influences of Mass Media on Child Health Behavior

When we turn to the question of the influence of mass media on the health of childrec, we very quickly come to focus on television. Television, of course, is only one among the many media-magazines, newspapers, comic books, radio, recordings, and movies-that touch on the lives of children. Nevertheless, television stands first in so many respects that, if it would be inaccurate to say that it stands alone it is absolutely correct to say that it is preeminent. Television is the first mass medium to reach children. It will, throughout their childhood and adolescence, consume more time than the classrooms of our schools and universities. Long before they will be able to attach the proper label to what they have seen, television will have introduced them to comedy, drama, news, and advertising. Its successful men and women will become their heroes and heroines, and its slogans and catchwords will enter their language. As they get older, they will turn more and more frequently to magazines and newspapers, and they will devote more and more hours to radio, to recordings, and going to the movies. Yet even then television will remain central, and when we look over the sweep of childhood and adolescence there is no question that it is television that principally commands our attention. Now the past decade has seen a remarkable change in public attitudes toward children and television. Since television joined the furniture in the American home in the 1950s, it has been a source of alarm and the target of criticism in regard to its possible influ-
Centrosome Protein Centrin 2/Caltractin 1 Is Part of the Xeroderma Pigmentosum Group C Complex That Initiates Global Genome Nucleotide Excision Repair*

Nucleotide excision repair (NER) is carried out by xeroderma pigmentosum (XP) factors. Before the excision reaction, DNA damage is recognized by a complex originally thought to contain the XP group C responsible gene product (XPC) and the human homologue of Rad23 B (HR23B). Here, we show that centrin 2/caltractin 1 (CEN2) is also a component of the XPC repair complex. We demonstrate that nearly all XPC complexes contain CEN2, that CEN2 interacts directly with XPC, and that CEN2, in cooperation with HR23B, stabilizes XPC, which stimulates XPC NER activity in vitro. CEN2 has been shown to play an important role in centrosome duplication. Thus, those findings suggest that the XPC-CEN2 interaction may reflect coupling of cell division and NER.
Adaptação de Interfaces em Ambientes Virtuais de Aprendizagem com Foco na Construção Dinâmica de Comunidades

Na medida em que crescem as experiencias com o uso sistematico dos AVAs, problemas decorrentes deste uso tem sido relatados. Com frequencia, esses problemas relacionam-se a enorme quantidade de informacao que precisa ser gerenciada e ao mesmo tempo estar disponivel para professores e estudantes, as interacoes entre os diversos participantes do processo e a dificuldade de perceber que as atividades dos outros tem impacto direto nas suas proprias atividades. Este artigo propoe uma solucao baseada em hipermidia adaptativa para gerar interfaces apropriadas para estacoes individuais de aprendizagem, valorizando a percepcao e considerando que os estudantes exercerem diferentes papeis nas varias comunidades em que participam.
Pulmonary metastasectomy in colorectal cancer: the PulMiCC trial

PulMiCC (Pulmonary Metastasectomy in Colorectal Cancer) is a randomised controlled trial funded by Cancer Research UK. Patients with a history of resected colorectal cancer who are found to have pulmonary metastases are first registered for evaluation and, if subsequently eligible for the trial, they are invited to be randomly allocated to ‘active monitoring’ or ‘active monitoring with pulmonary metastasectomy’. The clinical outcomes are overall survival, relapse-free survival, lung function and patient-reported quality of life.
Optimizations of $p$-Cycle-Based Protection of Optical Multicast Sessions

The preconfigured protection cycle (p -cycle) approaches have been well studied for unicast traffic protection, but have been rarely applied to multicast traffic protection. In this paper, we first examine two integer linear programming (ILP) based heuristic algorithms, including spare capacity optimization of p -cycle-based tree protection (SOPT) and segment protection (SOPS), We also extend spare capacity optimization of p-cycle-based link protection (SOPL) and the efficiency ratio based unity-p-cycle heuristic algorithm (ERH) earlier proposed for unicast traffic protection to multicast traffic protection. In order to achieve the least total network resource consumption, we further consider a joint optimization design of p-cycle-based link protection (JOPL) and a nonjoint optimization design (NJOPL). We show that, compared with other multicast traffic protection schemes, the JOPL design consume the least total capacity, while the ERH design is the fastest in the computation speed.