Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and pharmacokinetic profile of gadobenate dimeglumine in subjects with renal impairment.

RATIONALE AND OBJECTIVES To determine the safety and pharmacokinetics of gadobenate dimeglumine in a group of subjects with moderate or severe renal impairment. METHODS The safety and pharmacokinetic profile of gadobenate dimeglumine, a gadolinium (Gd3+) chelate complex in development as a contrast agent for MRI, were evaluated in a placebo-controlled, double-blind, multicenter trial. Subjects with moderate or severe renal impairment (creatinine clearances of 31 to 60 or 10 to 30 mL/min, respectively) received a 0.2-mmol/kg intravenous bolus of Gd3+ or saline placebo. Blood samples (up to 72 hours) and urine and fecal samples (up to 216 hours) were assayed for total Gd3+ content by inductively coupled plasma atomic emission spectroscopy. Gd3+ blood concentration/time data were analyzed nonparametrically and parametrically using the software program WinNonlin VI.1. RESULTS Mean (SD) values for Gd3+ area under the curve, blood clearance, steady-state volume of distribution, renal clearance, and creatinine clearance for the moderate group were 862 (392) micrograms.h/mL, 56 (25) mL/min, 21 (5) L, 47 (23) mL/min, and 46 (16) mL/min. Values for the severe group were 1347 (366) micrograms.h/mL, 31 (7) mL/min, 19 (6) L, 22 (7) mL/min, and 21 (8) mL/min. No Gd(3+)-related adverse events occurred. Mean values for Gd3+ recovery in urine and feces for moderate and severe groups were 74% and 6%, and 69% and 8% of the dose, respectively. Linear regression analysis demonstrated a significant relation between the level of renal function and blood clearance of Gd3+. CONCLUSIONS Although mean blood clearance and renal clearance values progressively declined with increasing degree of renal impairment, based on the safety profile and the fact that the administered dose was double the standard dose used for MRI purposes, there appears to be no need for dose reduction in this population.
Universal scaling and intrinsic classification of electro-mechanical actuators

Actuation characteristics of electromechanical (EM) actuators have traditionally been studied for a few specific regular electrode geometries and support (anchor) configurations. The ability to predict actuation characteristics of electrodes of arbitrary geometries and complex support configurations relevant for broad range of applications in switching, displays, and varactors, however, remains an open problem. In this article, we provide four universal scaling relationships for EM actuation characteristics that depend only on the mechanical support configuration and the corresponding electrode geometries, but are independent of the specific geometrical dimensions and material properties of these actuators. These scaling relationships offer an intrinsic classification for actuation behavior of a broad range of EM actuators with vastly different electrode/support geometries. Consequently, the problem of analysis/design of complex EM actuators is reduced to the problem of determining only five scaling param.
Rodent models for urodynamic investigation

Rodents, most commonly rats, mice, and guinea pigs are widely used to investigate urinary storage and voiding functions, both in normal animals and in models of disease. An often used methodology is cystometry. Micturitions in rodents and humans differ significantly and this must be considered when cystometry is used to interpret voiding in rodent models. Cystometry in humans requires active participation of the investigated patient (subject), and this can for obvious reasons not be achieved in the animals. Cystometric parameters in rodents are often poorly defined and do not correspond to those used in humans. This means that it is important that the terminology used for description of what is measured should be defined, and that the specific terminology used in human cystometry should be avoided. Available disease models in rodents have limited translational value, but despite many limitations, rodent cystometry may give important information on bladder physiology and pharmacology. The present review discusses the principles of urodynamics in rodents, techniques, and terminology, as well as some commonly used disease models, and their translational value. Neurourol. Urodynam. Neurourol. Urodynam. 30:636–646, 2011. © 2011 Wiley‐Liss, Inc.
Evaluation of cerebral dyschromatopsia using color afterimage

Cerebral dyschromatopsia is traditionally evaluated by color discrimination tests such as the Farnsworth–Maunsell 100 Hue Test. These tests are also used to evaluate color-perception deficits caused by eye disease, and they do not tell us whether color perception is impaired in the eye or in the brain. Here, we used color afterimage to isolate color-perception deficits in the brain from those in the eyes, in a patient with cerebral dyschromatopsia. The results showed that the patient perceived color afterimage of yellow and blue with abnormal duration and chromaticity. On the other hand, the patient performed normally on the Farnsworth–Maunsell 100 Hue Test. We conclude that the color afterimage test would be useful to evaluate color perception in the brain.
Measuring photon numbers in a cavity by atomic interferometry: optimizing the convergence procedure

We describe the optimum detection procedure to follow in order to measure by atomic interferometry the number of photons present in a cavity by using a Quantum nondemolition scheme. The method we discuss is the one recently introduced by Brune et al. [1, 2], in which the field intensity is detected by recording atomic interferences in a Ramsey type set up. A succession of twc-level atoms interacts with the cavity field which is the analog of a birefringent retarding plate for the atomic wave function. The information is acquired in the form of binary digits (atoms detected in one level or the other). We discuss an optimal strategy which yields the value of the photon a atoms the base 2 logarithm of the field photon number dispersion. The procedure described here is the one we intend to use in an experiment in preparation.
Enhancing Privacy of Electronic Coins through Cryptography

In computerized world there are different sites without further ado has the circumstances where individuals execute and the exchange is for the most part done by the money and money is presently electronic. Focal thought of this paper is to think about Al the electronic money framework. This paper portrays how the every one of the conventions works, their properties and different parameters favorable circumstances inconveniences. At long last, it finishes up by correlation of every one of these conventions
Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis

Background: The aim of the present meta-analysis is to determine the efficacy of tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis. Materials and Methods: MEDLINE, EBSCO, Cochrane database, and Google Scholar were used to identify studies in English published up to January 31, 2017. An additional hand search of relevant journals and of the bibliographies of the paper identified was also performed. Articles retrieved were screened using specific inclusion criteria by two independent reviewers. Randomized control trials investigating the effect of tetracycline group of antibiotics as local drug delivery agents in chronic periodontitis were included in the study. Results: Ten relevant articles were selected for the meta-analysis, of which five articles were retrieved after electronic search, three articles were included after hand search, and two unpublished articles were included. The number of patients in studies ranged from 13 to 140 sites with mean age ranging from 20 to 75. A total of 588 sites were treated using tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis. The meta-analysis showed standard difference in mean −1.02 mm (95% confidence interval [CI] 0.28, 1.75) for clinical gain in attachment in favor of tetracycline group. Standard difference in mean for probing depth (PD) was 1.20 mm (95% CI 0.57, 1.87) in tetracycline group. Conclusion: The results of this meta-analysis showed a significant improvement in periodontal parameters such as CAL, PD, and sulcular bleeding index in favor of tetracycline as local drug delivery compared to placebo.
Microscopy techniques applied for monitoring the development of aquatic biofilms

Using an experimental setup based on packed bed reactors (filled with glass beads) supplied with water from a groundwater source, the suitability of different microscopic techniques for biofilm monitoring was evaluated. Confocal microscopy is the most versatile, applicable and suitable technology for biofilm study and even provides information about the main surface and height parameters. Nevertheless, the wide field images obtained with the confocal perfilometer, combined with the super-long work distances of the objectives used, facilitate and improve the observation of non-flat surfaces. Moreover, the utilization of a white light source does not affect the viability and the activity of microbial cells. Confocal perfilometry can be the choice for a non-invasive monitoring of the microbial colonization of non-flat surfaces, such as the glass beads. Other techniques such as the Environmental Scanning Electron Microscopy (ESEM), cryoembedding and cryosectioning can be useful as complementary tools to help in the characterization of the structure and architecture of mature biofilms.
Nanoindentation as a tool for understanding nano-mechanical properties of wood cell wall and biocomposites

Cellulose fibers, cell wall fragments and cellulose microfibrils can be used as reinforced materials for biocomposite manufacture. Understanding nano-mechanical properties of those materials will be very useful to show their full theoretical potential. Nanoindentation testing is a technique that determines the mechanical properties of a material in the sub-micron/nano scale. The test involves penetrating a sample material using an indenter, while the penetration depth and load are recorded so that the stiffness and hardness of the indented location can be subsequently calculated. The objective of this study was to understand the mechanical properties of wood cell wall, regenerated cellulose fiber and cellulose fiberreinforced polypropylene composite using nanoindentation. The effect of microfibril angle on the hardness and stiffness values of wood cell wall and the mechanical properties of interphase between regenerated cellulose fiber and polypropylene were investigated. Time dependent mechanical properties of regenerated cellulose fiber in longitudinal and transverse direction were also investigated.
Prevalence of CagA and VacA genotype of Helicobacter pylori in Thai children.

UNLABELLED Seroprevalence of Helicobacter pylori infection in children is variable according to geographical location and family sanitation. A previous study in Bangkok showed an incidence of 25.5% in 1998. The higher incidence in the urban and rural area is predicted in lower economic classes and poor sanitation. OBJECTIVE To study the occurance of CagA and VacA genotype in Thai children using the Western blot technique. MATERIAL AND METHOD Sera of 159 Thai native children aged 0-15 year without associated abdominal pain from different provinces in 4 parts of the Kingdom of Thailand were tested with the rapid screening test for H. pylori. The positive specimen was further tested with the Western blot technique for determination of Urea A (p37), CagA (p116) and VacA (p89). RESULT Fiftyfive andfifty two (34.6%) were tested positive by the rapid test while 32.7% were positivefor the band of current infection marker (CIM). The 28 selected positive sera with complete history of housing and water supply were analysed. Thai children living in urban areas have a higher prevalence and the CagA+, VacA+ are found in 96.43% of infected patients. The transmission may be through the water supply. CONCLUSION A high prevalence of Helicobacter pylori infection was found in childhood period in urban areas and may be associated with the local water supply.
Correlation between Central Corneal Thickness and Intraocular Pressure Measured by Goldmann Applanation Tonometry or Pascal Dynamic Contour Tonometry

Abstract Purpose: The aim of this study was to investigate the relationship between central corneal thickness and intraocular pressure measured by Goldmann applanation tonometry and Pascal dynamic contour tonometry. Patients and Methods: The study included 45 persons (90 eyes), divided into 4 groups: a) 10 normal volunteers (20 eyes); b) 16 patients (32 eyes) with primary open-angle glaucoma; c) 8 patients (16 eyes) with normal-tension glaucoma; and d) 11 patients (22 eyes) with ocular hypertension. Intraocular pressure was measured by Goldmann applanation tonometry and Pascal dynamic contour tonometry, and central corneal thickness was measured by ultrasound pachymetry. The relationship between intraocular pressure and central corneal thickness was evaluated. Results: Intraocular pressure was correlated positively but not strongly enough with central corneal thickness when it was measured by Goldmann applanation tonometry. On the contrary, there was no correlation between intraocular pressure and central corneal thickness when intraocular pressure was measured by Pascal dynamic contour tonometry. Conclusion: Central corneal thickness is an important variable in the evaluation of intraocular pressure by Goldmann applanation tonometry. This factor does not interfere with the intraocular pressure measurements taken by Pascal dynamic contour tonometry.
Visible skin colouration predicts perception of male facial age, health and attractiveness

Although there is evidence that perception of facial age, health and attractiveness is informed by shape characteristics as well as by visible skin condition, studies on the latter have focused almost exclusively on female skin. Recent research, however, suggests that a decrease in skin colour homogeneity leads to older, less healthy and less attractive ratings of facial skin in both women and men. Here, we elaborate on the significance of the homogeneity of visible skin colouration in men by testing the hypothesis that perception of age, health and attractiveness of (non‐contextual) digitally isolated fields of cheek skin only can predict that of whole facial images. Facial digital images of 160 British men (all Caucasian) aged between 10 and 70 were blind‐rated for age, health and attractiveness by a total of 147 men and 154 women (mean age = 22.95, SD = 4.26), and these ratings were related to those of corresponding images of cheek skin reported by Fink et al. (J. Eur. Acad. Dermatol. Venereol. in press). Linear regression analysis showed that age, health and attractiveness perception of men’s faces could be predicted by the ratings of cheek skin only, such that older men were viewed as older, less healthy and less attractive. This result underlines once again the potent signalling role of skin in its own right, independent of shape or other factors and suggests strongly that visible skin condition, and skin colour homogeneity in particular, plays a significant role in the perception of men’s faces.
Contrast-enhanced endobronchial ultrasound: Potential value of a new method

Endobronchial ultrasound (EBUS) has gained importance for mediastinal lymph node staging. Contrast-enhanced EBUS is so far not a discussed technique including contrast-enhanced high mechanical index (MI)-EBUS and potentially contrast-enhanced low MI-EBUS. Possible use could include characterization of mediastinal lymph nodes for better selection of biopsies, differential diagnosis of the primary tumor, and evaluation of thrombosis or tumor in vein infiltration.
A Phase II Study of Tg4010 (Mva-Muc1-Il2) in Association with Chemotherapy in Patients with Stage III/IV Non-small Cell Lung Cancer

Background: TG4010 is a recombinant viral vector expressing both the tumor-associated antigen MUC1 and Interleukine-2. This vector is based on the modified virus of Ankara, a significantly attenuated strain of vaccinia virus. TG4010 has been designed to induce or amplify a cellular immune response directed against tumor cells expressing MUC1. Methods: A multicenter, randomized phase II study has explored two schedules of the combination of TG4010 with first line chemotherapy in patients with stage IIIB/IV non-small cell lung cancer. In Arm 1, TG4010 was combined upfront with cisplatin (100 mg/m2 day 1) and vinorelbine (25 mg/m2 day 1 and day 8). In Arm 2, patients were treated with TG4010 monotherapy until disease progression, followed by TG4010 plus the same chemotherapy as in Arm1. Response rate was evaluated according to RECIST. Median time to progression and median overall survival were calculated according to the Kaplan–Meier method. Results: Sixty-five patients were enrolled, 44 in Arm 1 and 21 in Arm 2, in accordance with the two stage Simon design of the statistical plan. In Arm 1, partial response was observed in 13 patients out of 37 evaluable patients (29.5% of the intent to treat population, 35.1% of the evaluable patients). In Arm 2, two patients experienced stable disease for more than 6 months with TG4010 alone (up to 211 days), in the subsequent combination with chemotherapy, one complete and one partial response were observed out of 14 evaluable patients. Arm 2 did not meet the criteria for moving forward to second stage. The median time to progression was 4.8 months for Arm 1. The median overall survival was 12.7 months for Arm 1 and 14.9 for Arm 2. One year survival rate was 53% for Arm 1 and 60% for Arm 2. TG4010 was well tolerated, mild to moderate injection site reactions, flu-like symptoms, and fatigue being the most frequent adverse reactions. A MUC1-specific cellular immune response was observed in lymphocyte samples from all responding patients evaluable for immunology. Conclusions: The combination of TG4010 with standard chemotherapy in advanced non-small cell lung cancer is feasible and shows encouraging results. A randomized study evaluating the addition of TG4010 to first line chemotherapy in this population is in progress.
BIOTECHNOLOGICALLY RELEVANT ENZYMES AND PROTEINS Substrate specificity and membrane topologies

Polyunsaturated fatty acids (PUFAs) are essential lipids for cell function, normal growth, and development, serving as key structural components of biological membranes and modulating critical signal transduction events. Omega-3 (n-3) long chain PUFAs (LC-PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to protect against inflammatory diseases and enhance brain development and function. This had led to a marked increase in demand for fish and fish oils in human diets, supplements, and aquaculture and created a need for new, sustainable n-3 LC-PUFA sources. We have studied for the first time homogenous preparations of the membrane-typeω6 andω3 fatty acid desaturases from the fungus Mortierella alpina, as a model system to produce PUFAs. These desaturases possess a diiron metal center and are selective for 18:1 n-9 and 18:2 n-6 acyl-CoA substrates, respectively. Sequence alignments and membrane topology predictions support that these enzymes have unique cap regions that may include the rearrangement and repositioning of the active site, especially when compared to the mammalian stearoyl–coenzyme A desaturase-1 (SCD1) and the related sphingolipid α-hydroxylase (Scs7p) that act upon different substrates.
Distribution of decane within the unit cell of the inverted hexagonal (HII) phase of lipid-water-decane systems determined by neutron diffraction.

The addition of a free alkane such as decane to lipid-water systems is known to promote the formation of a low-temperature inverted hexagonal (HII) phase [Kirk, G. L. , & Gruner, S. M. (1985) J. Phys. (Paris) 46, 761]. Kirk et al. [Kirk, G. L. , Gruner, S. M. , & Stein, D. E. (1984) Biochemistry 23, 1093] have discussed the hydrocarbon packing anisotropy in the HII unit cell and have suggested that free alkane will distribute in a way that reduces this packing anisotropy by allowing the lipid chain environment to become more uniform. By combining neutron and X-ray diffraction data to do a Fourier reconstruction of the HII phase of dioleoylphosphatidylethanolamine (DOPE) + water + deuterated decane, it was found that the decane preferentially partitions into the interstitial regions of the HII unit cell where it should be the most effective in alleviating the hydrocarbon chain packing stress, supporting the suggestion of Kirk et al. Using the distribution of decane within the unit cell, we have calculated the lipid length distribution for the situations with and without added alkane. With a suitable molecular model, this lipid length distribution may eventually be used to calculate the free energy change upon the addition of alkane. Such a measurement is important for a more realistic understanding of the interactions which lead to the formation of the HII phase.
The Impact of Ethical Leadership on Team Performance: Leader - Member Exchange Mean, Shared Mental Model as an Intermediary

This paper summarizes the progress, development and research progress of ethical leadership, leader-member exchange means and shared mental model by reviewing domestic and foreign research results. On the basis of this, this paper also summarizes the research on ethical leadership and team performance. The research on ethical leadership, leader-member exchange means and team performance is reviewed. The research on ethical leadership, shared mental model and team performance is reviewed. For the future research provides some research ideas, consolidate the literature foundation.
The Social Capital Relation Network Analysis of Chinese Governors

The social relation network of officials has an important effect on official promotion. Nowadays the measurement of the network is focused on the individual network of officials, and the research about measuring the whole network between officials is scarce. This article collects the samples from 154 Governors since 2000, defines and measures the Governors network from the view of the whole network through Ucinet, a Social Network Analysis software. Based on the identification of network border, the article defines the Governors network as the direct and indirect relation set of Governors having worked in the same province, and analyzes the density and centrality of the network. What’s more, it carries on the expanded research, trying to explore the relationship between Governors network and official promotion. It will increase the measurement index of social network and provide reference for more quantitative research on the relation between social network and official promotion.