Miracle-dz/UniFAR-FTUs huggingface dataset:
Exercise and Hematopoietic Stem and Progenitor Cells: Protection, Quantity, and Function

The effects of exercise on mature cells of the hematopoietic lineage have been well characterized; however, the effects of exercise on the more primitive cells of the hematopoietic system are unknown. Here, we propose that the benefits of exercise apply to hematopoietic progenitors and that exercise increases hematopoietic stem cell quantity primarily mediated via adaptations in the stem cell niche.
Endogenous Growth and Agglomeration Economies in Korean Manufacturing: A Sign of Declining Competitiveness *

This study evaluates competitiveness in Korean manufacturing from the aspect of scale economies in an endogenous-growth framework. The paper investigated agglomeration economies (urbanization and localization economies) and endogenous-technology economies in Korean manufacturing using industry- and city-sorted data. The study shows that the measure of efficiency estimated by the sum of agglomeration economies and endogenous-technology economies was at the lowest level in 1981, but it continued to improve until 1990 when such a trend started to reverse, and the declining phase of efficiency became pronounced by 1993. Empirical results suggest that the deterioration of external and internal scale economies in the Korean manufacturing sector seems to be a key factor in explaining the slowdown in the potential growth of the Korean economy.
Effect of Lepidium sativum L. (Garden Cress) Seed and Its Extract on Experimental Eimeria tenella Infection in Broiler Chickens

The anticoccidial effects of Lepidium sativum (LS) seed were assessed on 240, male, broiler chickens aged 1 d following oral inoculation of 1 × 10 5 sporulated E. tenella oocysts. The experimental study was conducted at the Debre Zeit Agricultural Research Center Poultry Farm. LS was included in the feed of the chickens in the form of seed powder, whole seed or extract. Broiler chickens were assigned to eight treatments: noninfected and unsupplemented (control check), infected and unsupplemented (control), infected and supplemented with seed powder, whole seed, extract or amprolium and noninfected and supplemented with seed powder or whole seed. One g.kg -1 of each seed preparation in feed was applied. Treatments were applied for a period of 2 wk from day 18 of hatching. Treatment efficacy was assessed based on measuring and the analysis of the parameters: 1) performance measures (body weight gain, feed intake, mortality); 2) fecal oocysts measurements; and 3) intestinal lesion scores. The body weight gains of E. tenella-challenged chickens fed LS-supplemented diets were significantly (P < 0.003) higher than those fed the control diet. Chickens fed the LS-supplemented diet following E. tenella infection demonstrated a significantly higher reduction of mortality (P < 0.0001), fecal oocyst shed (P < 0.0007) and lesion score (P < 0.0001) than those fed the unsupplemented or control diet. However, noninfected chickens fed seed powder of the LS-supplemented diet showed lesion scores and mortality. Lepidium sativum-supplemented diets demonstrated effective anticoccidial results on E. tenella-challenged chickens.
Analytical Calculation of the Modes in a Substrate Integrated Waveguide

A first order analytical method is developed to analyze the guided modes in substrate integrated waveguides. The complex propagation constant is derived as a closed expression which is a function of frequency, and geometrical and material parameters. This single equation is able to describe multimode and band gap effects in substrate integrated waveguides. Therefore, the initial design procedure can be greatly simplified by using this analytical model as starting point
Combining PMTCT With Active Case Finding for Tuberculosis

Summary: Tuberculosis (TB) is the preeminent manifestation of HIV infection and has become a leading cause of maternal mortality and morbidity in high HIV-prevalence settings. Active TB in pregnant women has potentially serious consequences for fetuses and newborns. In Soweto, South Africa, there is a more than 90% uptake of voluntary counseling and HIV testing during routine antenatal care, and almost one third of pregnant women are HIV-infected. The posttest counseling session of the prevention of mother-to-child transmission program provides an opportunity to screen HIV-infected pregnant women for TB. In this study, 370 HIV-infected pregnant women were screened for symptoms of active TB by lay counselors at the posttest counseling session. If symptomatic, they were referred to nurses who investigated them further. Eight women were found to have previously undiagnosed, smear-negative, culture-confirmed TB (2160/100,000). The mean CD4 count in those with active TB compared to those without TB was 276 × 106 cells per liter vs 447 × 106 cells per liter (P = 0.051). Symptoms most associated with active TB were hemoptysis and fever. We conclude that rates of TB in HIV-infected pregnant women are high, and screening for TB during routine antenatal care should be implemented in high HIV-prevalence settings.
The Impact of SFAS 123R on Changes in Option-Based Compensation

We investigate the determinants and consequences of the changes in option-based compensation for the top five executives around the issuance of SFAS 123R. We find that the reduction in the proportion of total compensation paid in employee stock options (ESOs) increases in (1) the firm's tendency to take advantage of ESO's favorable accounting treatment to report higher earnings in the pre-expensing period (as proxied by debt contracting concerns, pressure to meet or beat earnings benchmarks and corporate governance strength); and (2) the amount of ESO expense to be recognized upon adopting SFAS 123R (as proxied by the values of annual ESO grants and unvested outstanding ESOs pre SFAS 123R). Our findings are consistent with ESOs' favorable accounting treatment prior to SFAS 123R having a significant effect on boards' executive compensation decisions. We show that firms were more likely to replace ESOs with restricted stock but not with other forms of compensation post SFAS 123R. The substitution between restricted stock and ESOs, however, was far less than dollar for dollar, and that ESO cutbacks around the issuance of SFAS 123R resulted in reduced abnormal compensation.
[Behavior of the pressure of the lower esophageal sphincter after intravenous administration of domperidone in normal subjects].

Manometric studies on the action of domperidone 10 mg and 20 mg i.v. on the lower esophageal sphincter pressure (LESP) have been carried on ten healthy volunteers. Domperidone inhibits dopamine receptors and results in an increase of LESP. A dose of 10 mg produces a significant increase in LESP which is rapid and prolonged for thirty minutes; a dose of 20 mg is less efficient. The stimulatory effect of domperidone on LESP suggests an important role for endogenous dopamine as an inhibitory neuromodulator of LES pressure. The use of domperidone in therapy for reflux esophagitis is suggested.
NET Institute* www.NETinst.org

Social broadcasting networks such as Twitter in the U.S. and \Weibo" in China are transforming the way online word-of-mouth (WOM) is disseminated and consumed in the digital age. We investigate whether and how Twitter WOM a(cid:11)ects movie sales by estimating a dynamic panel data model using publicly available data and well known machine learning algorithms. We (cid:12)nd that chatter on Twitter does matter, however, the magnitude and direction of the e(cid:11)ect depends on whom the WOM is from and what the WOM is about. Measuring Twitter users’ in(cid:13)uence by how many followers they have, we (cid:12)nd that the e(cid:11)ect of WOM from more in(cid:13)uential users is signi(cid:12)cantly larger than that from less in(cid:13)uential users. In support of some recent (cid:12)ndings about the importance of WOM valence on product sales, we also (cid:12)nd that positive Twitter WOM increases movie sales while negative WOM decreases them. Interestingly, we (cid:12)nd that the strongest e(cid:11)ect on movie sales comes from those tweets where the authors express their intention to watch a certain movie. We attribute this to the dual e(cid:11)ects of such intention tweets on movie sales: the direct e(cid:11)ect through the WOM author’s own purchase behavior, and the indirect e(cid:11)ect through either the awareness e(cid:11)ect or the persuasive e(cid:11)ect of the WOM on its recipients. Our (cid:12)ndings provide new perspectives to understand the e(cid:11)ect of WOM on product sales and have important managerial implications. For example, our study reveals the potential values of monitoring people’s intention and sentiment on Twitter and identifying in(cid:13)uential users for companies wishing to harness the power of social broadcasting networks.
User Acceptance of Entertainment Services via Mobile Phone System in Hong Kong

The main contribution of this project is offering theoretical and empirical insights related to the acceptance of entertainment services via the use of mobile phone system in customer’s perspective. In particular, the objectives of this project are explaining user acceptance of entertainment services via mobile phone system in Hong Kong and to provide evidence that perceived ease of use and perceived enjoyment dominant perceived usefulness as the greatest predictors of intention to use entertainment services via mobile phone system. A model was developed based on van der Heijden’s extended TAM model (2004). In this project, analysis is based on 217 respondents (mainly youth) to examine the relative effects of perceived usefulness, perceived ease of use and perceived enjoyment on usage intention. The result of the path analysis indicated that perceived usefulness, perceived ease of use and perceived enjoyment are significant in explaining user intention to use entertainment services through mobile phone system. Perceived ease of use is significant to both perceived enjoyment and perceived usefulness. The analysis also showed that, perceived ease of use and perceived enjoyment have greater predictive power than perceived usefulness. These findings are important and useful for mobile phone entertainment service providers. It is recommend that they can improve performance of their businesses by making their services easier to use and more enjoyable. User Acceptance of Entertainment Services via Mobile Phone System in Hong Kong Acknowledgement I would like to express my gratitude to my project supervisor, Dr. Vincent Chow W.S. , for his continuous guidance and support throughout the course of this research project. Moreover, I would like to give great thanks to all respondents of my questionnaire. Without their cooperation, the study would not have been possibly accomplished. User Acceptance of Entertainment Services via Mobile Phone System in Hong Kong Table of
Opening the door to innovation in cloud computing

This paper describes research-in-progress that explores the applicability and implications of cloud computing in the creation of business value through open innovation. Both the cloud computing and open innovation paradigms represent recent phenomenon and as such many unanswered questions still persist. In responding to this research gap we propose a new value creation framework which is based on a review of the literature on cloud computing, innovation, open innovation and value. Taking the framework layer by layer, this research in progress shall evaluate the innovation potential across components capable of offering value to organisations. The main contribution of this paper lies in proposing a framework that seeks to identify best route(s) to value, thus providing a visual mapping to enable organisations determine which cloud computing components, implementations, solutions and innovation approach is most suitable for value attainment.
The Effect of Auditor Reputation on the Pricing of Accruals: Evidence from Privately Held Companies

The aim of this paper is to test whether the pricing of accruals depends on auditor reputation. Using a wide sample made up of Spanish privately held firms for the period 1996-2002, we show that the inverse correlation between accruals quality and cost of debt reported by Francis et al. (2005) only holds when the auditor belongs to a Big 4 firm. When the auditors are national majors or local audit firms, an increase of accruals quality does not lead to a significant decrease in the cost of debt.
Prediction of long-term survival using expression of FOXA1, a determinant of estrogen response domains in breast cancer.

539 Background: Recent studies have demonstrated cofactor dependency of estrogen receptor alpha (ERα) in defining specific pattern of estrogen (E2) response in breast cancer. FOXA1, also called HNF3α, a forkhead family transcription factor, has emerged as a major cofactor that is essential for optimum transcription of ∼50% of ERα:E2 responsive genes. FOXA1 is expressed in breast cancer cells and in cDNA microarray cluster analysis segregates with genes that characterize the luminal A subtype such as ERα, GATA3, and XBP-1. Detailed expression analysis of FOXA1 in human breast tumors has not been previously performed and it is not known whether it is an independent prognostic factor in breast cancer. METHODS A tissue microarray comprising tumors from 438 patients with 20 years follow-up was analyzed for FOXA1 expression using goat-anti-human FOXA1 antibody by immunohistochemistry. Percentage (P) and intensity (I) of expression was analyzed to generate numerical score (S= P × I). FOXA1 expression was correlated with tumor grade, nodal status, disease free survival, and expression of ER, PR, GATA3, HER2, p27kip1, phospho-AKT, and luminal A subtype (defined as ER &/or PR+, bcl-2+ and Her-2-neg). RESULTS FOXA1 expression (score greater than 100) was seen in 187 of 438 breast cancers and correlated with greater likelihood of survival at 20 year (p=0.0114). A significant positive correlation was observed between FOXA1 expression and expression of ERα (p= 0.000001), GATA3 (p= 0.000001), PR (p= 0.00001), phospho-AKT (p= 0.00001). Similarly, a significant correlation was noted with luminal A subtype. An inverse correlation was noted with tumor grade and mdm-2 expression (p=0.00001). HER2 or p27kip1 expression and nodal status showed no correlation with FOXA1. CONCLUSIONS FOXA1 is good prognostic marker predicting disease free survival in patients with breast cancer. Since its expression correlates well with breast cancer of luminal A subtype, it can also be used to identify these good prognosis tumors from the rest of the ER positive breast cancers in archival paraffin embedded breast tissues. No significant financial relationships to disclose.
Different responsiveness of central nervous system tissues to oxidative conditions and to the antioxidant effect of melatonin

Abstract: Melatonin, a product of the pineal gland, is an effective free‐radical scavenger both in vitro and in vivo. Free‐radical‐mediated lipid peroxidation has been increasingly considered as an important factor in post‐traumatic neuronal degeneration. The aim of the present study was (i) to examine the responses of different regions of central nervous system (CNS) to free‐radical generation induced in vitro and (ii) to test the efficacy of melatonin in reducing oxidative damage in different regions of the CNS. Rat brain, total spinal cord, spinal cord white matter and optic nerves were dissected with the rats under general anesthesia and immediately frozen at −20°C. Thiobarbituric acid reactive substances were measured as an index of lipid peroxidation. Peroxidation was induced with ferrous iron (0.02 mm), ascorbate (1 mm), and hydrogen peroxide (H2O2) (0.5 mm). All tissue samples showed increased lipid peroxidation levels after treatment with free‐radical generating agents. The highest amount of damage was observed in the presence of ferrous iron, ascorbate, and H2O2. Melatonin showed antioxidant effects in the brain, total spinal cord, optic nerve, and spinal cord white matter. The results show that melatonin has differential protective effects on CNS tissues in vitro and the most potent effect is observed in the spinal cord white matter.
of the United States' Most Important Trade Partner

Canada has become the most important trading partner of the United States in terms of total trade and agricultural trade. In 2005, exports to Canada amounted to 23 percent of total U.S. exports and 17 percent of U.S. agricultural exports, while imports from Canada amounted to 17 percent of total U.S. imports and 21 percent of U.S. agricultural imports. Canada is a large exporter to the United States of critical raw materials, including natural gas, petroleum, and wood products, and a substantial importer of finished industrial and consumer goods. Canadian agricultural exports to the United States are primarily in consumer processed goods such as beef, fish, seafood, breads, and confectionery items, while Canadian imports from the United States include baked goods, fruit and vegetable juices, and fresh fruits and vegetables. Canadian agricultural trade continues to grow in importance reflecting trade liberalization and greater integration of agricultural markets. The trade outlook is enhanced by Canada’s prospects for long-term economic growth of about 3 percent per year, which is underpinned by expected moderate growth in working-age population and labor productivity.
Electromagnetic Performance of Stator Slot Permanent Magnet Machines With/Without Stator Tooth-Tips and Having Single/Double Layer Windings

Novel stator slot permanent magnet (SSPM) machines with doubly salient structure have attractive features, such as a robust rotor and fail-safe capability during faults due to their peculiar PM excitation characteristics. In this paper, average electromagnetic torque production in SSPM machines is investigated using the frozen permeability analysis for the 12/10 stator/rotor pole machine. The single layer (SL) and double layer (DL) winding SSPM machines with 12/10 stator/rotor poles are further investigated, accounting for the influence of stator tooth-tips. The key findings include that the average electromagnetic torque can be enhanced by 9%-10% at the rated current for the DL and SL winding machines with stator tooth-tips. The influence of design parameters, open-circuit characteristics, inductances, electromagnetic torque, torque ripple, and losses is studied. Finally, the 2-D finite-element analysis is experimentally validated.
Androgen‐deprivation regimen for multiple bone metastases of extramammary Paget disease

1 LeBoit PE. Granuloma faciale: a diagnosis deserving of dignity. Am J Dermatopathol 2002; 24:440–3. 2 Roberts PF, McCann BG. Eosinophilic angiocentric fibrosis of the upper respiratory tract: a mucosal variant of granuloma faciale? A report of three cases. Histopathology 1985; 9:1217–25. 3 Pinkus H. Granuloma faciale. Dermatologica 1952; 105:85–99. 4 Cecchi R, Paoli S, Giomi A. Granuloma faciale with extrafacial lesions. Eur J Dermatol 2002; 12:438. 5 Sears JK, Gitter DG, Stone MS. Extrafacial granuloma faciale. Arch Dermatol 1991; 127:742–3. 6 Johnson WC, Higdon RS, Helwig EB. Granuloma faciale. Arch Dermatol 1959; 79:42–52. 7 Tabaee A, Zadeh MH, Proytcheva M, LaBruna A. Eosinophilic angiocentric fibrosis. J Laryngol Otol 2003; 117:410–13. 8 Holmes DK, Panje WR. Intranasal granuloma faciale. Am J Otolaryngol 1983; 4:184–6. 9 Burns BV, Roberts PF, De Carpentier J, Zarod AP. Eosinophilic angiocentric fibrosis affecting the nasal cavity. A mucosal variant of the skin lesion granuloma faciale. J Laryngol Otol 2001; 115: 223–6. 10 Dinehart SM, Gross DJ, Davis CM, Herzberg AJ. Granuloma faciale: comparison of different treatment modalities. Arch Otolaryngol Head Neck Surg 1990; 116:849–51.
CONCENTRACIÓN ACCIONARIAL Y LIQUIDEZ DE MERCADO: UN ANÁLISIS CON ECUACIONES SIMULTÁNEAS *

This paper analyzes the relationship between ownership concentration and shares liquidity for a sample of 115 listed firms that traded during the period from April 2000 to December 2000. Results show a negative influence of ownership of directors, major shareholders and outside shareholders on liquidity. We do not find evidence of the influence of liquidity on the ownership concentration. We also observe that the ownership concentration increases the adverse selection spread component. Therefore, firms with higher ownership concentration present larger informative asymmetry, having less liquidity.
Evaluation of PWM patterns of a matrix converter for reduction of output voltage harmonics

This paper presents the characteristics of the Pulse Width Modulation (PWM) patterns of the Matrix Converter (MC). The various PWM patterns of nine bi-directional switches for the MC can be established. All the combinations of duty cycles with four commutations in three phases during one control period using only input voltage values are derived. The PWM patterns of the derived duty cycles for low output voltage harmonics are evaluated. The characteristics and evaluations of the output voltage harmonics for the PWM patterns have been verified by theories and experiments.
Generation of biologically active retro‐genes upon interaction of mouse spermatozoa with exogenous DNA

Mature spermatozoa of most animal species can spontaneously take up foreign DNA molecules which can be delivered to embryos upon fertilization. Following this procedure, transgenic animals of various species have been generated. We recently discovered a reverse transcriptase (RT) activity in mouse spermatozoa that can reverse‐transcribe exogenous RNA molecules into cDNA copies. These cDNA copies are transferred to embryos at fertilization, mosaic propagated as non‐integrated structures in tissues of founder individuals and further transmitted to F1 progeny. Reverse‐transcribed sequences behave as functional genes, being correctly expressed in tissues of F0 and F1 animals. To learn more about this mechanism and further characterize the reverse transcription step, we have now incubated spermatozoa with a plasmid harboring a green fluorescent protein (EGFP) retrotransposition cassette interrupted by an intron in the opposite orientation to the EGFP gene. We found that reverse‐transcribed spliced EGFP DNA sequences are generated in sperm cells and transmitted to embryos in IVF assays. After implantation in foster mothers, embryos developed into mice that expressed EGFP in the blood vessel endothelia of a variety of organs. The EGFP‐encoding cDNA sequences were detected in positive tissues as extrachromosomal mosaic‐propagated structures, maintained in low‐copy number (<1 copy/genome), and mosaic transmitted from founders to the F1 progeny. These results indicate that an efficient machinery is present in mature spermatozoa, which can transcribe, splice, and reverse‐transcribe exogenous DNA molecules. This mechanism is implicated in the genesis and non‐Mendelian propagation of new genetic information besides that contained in chromosomes. Mol. Reprod. Dev. © 2006 Wiley‐Liss, Inc.
Role of the Diabetes Educator in Inpatient Diabetes Management

It is the position of American Association of Diabetes Educators (AADE) that all inpatient interdisciplinary teams include a diabetes educator to lead or support improvement efforts that affect patients hospitalized with diabetes or hyperglycemia. This not only encompasses patient and family education but education of interdisciplinary team members and achievement of diabetes-related organizational quality metrics and performance outcomes.