Miracle-dz/UniFAR-FTUs huggingface dataset:
Rôle de ADAM12 dans la Transition Epithélio-Mésenchymateuse

Les echanges entre les cellules tumorales et le microenvironnement jouent un role essentiel dans le developpement des tumeurs. Dans ce contexte, la nouvelle famille de metalloproteases, les proteines ADAM, constituent aujourd’hui des regulateurs majeurs de la progression tumorale en agissant sur la biodisponibilite des mediateurs de la communication cellulaire que sont les cytokines, chimiokines et facteurs de croissance. Au sein de cette famille, ADAM12 est la plus associee au cancer. Elle possede la particularite de jouer un role dans la signalisation cellulaire, de facon independante de son activite metalloprotease, notamment dans les voies de signalisation du TGFβ. Notre etude montre pour la premiere fois un role pour la forme membranaire d'ADAM12 dans l'induction de la transition epithelio-mesenchymateuse (EMT), un processus essentiel a l'invasion tumorale dont le TGFβ est un inducteur majeur. Cet effet est medie par l'activation des voies de signalisation du TGFβ, impliquant les proteines SMAD3, AKT et ERK et requiert le domaine cytoplasmique d'ADAM12L mais pas son domaine catalytique. L'activation de ces voies de signalisation pourrait impliquer une relocalisation d'ADAM12L au sein de plates-formes de signalisation dans les radeaux lipidiques. Par ailleurs, nous avons montre qu'ADAM12L interagit avec les proteines ZO-1 et ZO-2, des proteines des jonctions serrees, et pourrait favoriser leur desassemblage au cours de l'EMT. Nos travaux ont permis de mettre en evidence une nouvelle fonction pour ADAM12L dans l'EMT, par un mecanisme impliquant une modulation des signaux regulant ce processus. Une meilleure comprehension de la dynamique de ces mecanismes moleculaires pourrait permettre de developper de nouvelles therapies ciblees pour lutter contre la progression tumorale.
Double-blind cross-over comparison of indomethacin, flurbiprofen, and placebo in ankylosing spondylitis.

Preliminary studies of flurbiprofen, a newly introduced anti-inflammatory agent, have shown that it exerts some anti-inflammatory and analgesic effects in man when compared with placebo and is relatively well tolerated (Chalmers, Cathcart, Kumar, Dick and Buchanan, 1972). The purpose of this paper is to compare the effects of flurbiprofen, indomethacin, and placebo under double-blind conditions in a group of patients with ankylosing spondylitis.
Influence of Drugs of Abuse and Alcohol Upon Patients Admitted to Acute Psychiatric Wards: Physician’s Assessment Compared to Blood Drug Concentrations

AbstractIn acute psychiatric services, rapid and accurate detection of psychoactive substance intake may be required for appropriate diagnosis and intervention. The aim of this study was to investigate the relationship between (a) drug influence as assessed by physicians and (b) blood drug concentrations among patients admitted to acute psychiatric wards. We also explored the possible effects of age, sex, and psychotic symptoms on physician’s assessment of drug influence. In a cross-sectional study, the sample comprised 271 consecutive admissions from 2 acute psychiatric wards. At admission, the physician on call performed an overall judgment of drug influence. Psychotic symptoms were assessed with the positive subscale of the Positive and Negative Syndrome Scale. Blood samples were screened for a wide range of psychoactive substances, and quantitative results were used to calculate blood drug concentration scores. Patients were judged as being under the influence of drugs and/or alcohol in 28% of the 271 admissions. Psychoactive substances were detected in 56% of the blood samples. Altogether, 15 different substances were found; up to 8 substances were found in samples from 1 patient. Markedly elevated blood drug concentration scores were estimated for 15% of the patients. Physician’s assessment was positively related to the blood drug concentration scores (r = 0.52; P < 0.001), to symptoms of excitement, and to the detection of alcohol, cannabis, and amphetamines. The study demonstrates the major impact of alcohol and drugs in acute psychiatric settings and illustrates the challenging nature of the initial clinical assessment.
SAR Shape from shading in suburban areas

Shape-from-shading (SfS) techniques can be applied to synthetic aperture radar (SAR) images in order to obtain estimates of the slopes and, then, the elevation of the observed scene. Recently the authors proposed a new SfS technique for natural scenarios, based on the use of fractal surface models: problems can arise if non-natural features are present in the observed scene. In this paper, we evaluate the impact of manmade structures on the technique's performance: in particular, the SfS algorithm is applied on a SAR image in which a suburban environment is present. A deep analysis of the main issues is performed and possible solutions are presented and discussed.
Relative contribution of V‐H+ATPase and NA+/H+ exchanger to bicarbonate reabsorption in proximal convoluted tubules of old rats

With aging, the kidney develops a progressive deterioration of several structures and functions. Proximal tubular acidification is impaired in old rats with a decrease in the activity of brush border Na+/H+ exchange and a fall of H‐ion flux measured with micropuncture experiments. In the present work we evaluate the contribution of 5‐N‐ethyl‐n‐isopropyl amiloride‐ (EIPA) and bafilomycin‐sensitive bicarbonate flux () in proximal convoluted tubules of young and aged rats. We performed micropuncture experiments inhibiting the Na+/H+ exchanger with EIPA (10−4 M) and the V‐H+ATPase with bafilomycin (10−6 M). We used antibodies against the NHE3 isoform of the Na+/H+ exchanger and the subunit E of the V‐H+ATPase for detecting by Western blot the abundance of these proteins in brush border membrane vesicles from proximal convoluted tubules of young and old rats. The abundance of NHE3 and the V‐H+ATPase was similar in 18‐month‐old and 3‐month‐old rats. The bicarbonate flux in old rats was 30% lower than in young rats. EIPA reduced by 60% and bafilomycin by 30% in young rats; in contrast, EIPA reduced by ∼40% and bafilomycin by ∼50% in old rats. The inhibited by bafilomycin was the same in young and old rats: 0.62 nmol · cm−2· s−1 and 0.71 nmol · cm−2· s−1, respectively. However, the EIPA‐sensitive fraction was larger in young than in old rats: 1.26 nmol · cm−2· s−1 vs. 0.85 nmol · cm−2· s−1, respectively. These results suggest that the component more affected in bicarbonate reabsorption of proximal convoluted tubules from aged rats is the Na+‐H+ exchanger, probably a NHE isoform different from NHE3.
Versus Unfractionated Heparin in lective Percutaneous Coronary Intervention-Year Results From the STEEPLE ( SafeTy and Efficacy of noxaparin in Percutaneous coronary intervention patients , n internationaL randomized Evaluation ) Trial

ethods We conducted a follow-up analysis of clinical outcomes at 1 year in patients enrolled in the TEEPLE (SafeTy and Efficacy of Enoxaparin in Percutaneous coronary intervention patients, an internaionaL randomized Evaluation) trial of 3,528 patients undergoing elective PCI. Patients were randomized o receive either intravenous 0.50-mg/kg or 0.75-mg/kg enoxaparin or intravenous UFH during elective CI procedures. All-cause mortality at 1 year after index PCI was the main outcome measure.
Determination of the vectorelectrogram in isolated rat atria: application to the study of arrhythmias

Atrial tachyarrhythmias, the most frequent type of cardiac arrhythmia, are associated with increased stroke risk. Reentry and focal activity are considered as the main mechanisms underlying this dysfunction. In this study, we describe determination of the vectorelectrogram in isolated rat atria as a means to distinguish different patterns of electrical propagation. In all studied right atria beating at sinus rhythm, the mean electric vector (MEV) trajectory was clockwise, and each cycle was preceded by electric diastole (null MEV), either in the absence or presence of muscarinic cholinergic or β-adrenergic receptor stimulation. During cholinergic tachyarrhythmia (induced by high-rate electric stimulation in both atria, plus exposure to carbachol in left atria), vector loops were ellipsoidal and stable, with variable direction, and did not cross the origin, which is consistent with reentrant activation and with findings obtained in vivo by other authors. In contrast, during spontaneous activity induced by rapid pacing in isoproterenol-exposed left atria, vector loops were similar to those in right atria at sinus rhythm, thus suggestive of focal activity. It is concluded that the vectorelectrogram approach allows discrimination of different patterns of propagation during arrhythmia in isolated atria and may be useful for high-output tests of pro- and anti-arrhythmic compounds.
A fuzzy modified elastoplastic friction model for parameter estimation with MHE

Friction modeling plays a very important role in control and simulation systems. A lot of dynamic models are proposed to capture most of the friction behavior observed experimentally. Most dynamic models are typically considered to be dependent only on relative speed and relative displacement of contacting surfaces. However, it is known that dynamic characteristics of friction are affected by other factors besides speed and displacement. In this paper, a modified Elastoplastic model is presented in order to closely approximate the Elastoplastic model. In contrast to the Elastoplastic model, the modified model consists of an infinitely differentiable transition function. Such a model is well suited for gradient-based state and parameter estimation methods such as moving horizon estimation. To consider the friction changes caused by many other factors (e.g. load, temperature, lubrication, etc., but without speed and displacement), a fuzzy system is designed to establish a mapping between the other factors and the modified Elastoplastic model parameters. The complex effects of other factors on friction are fitted through the fuzzy system, while the dynamic characteristics of friction are not lost. Simulation results verify the effectiveness of the proposed model.
Benzene and human health: A historical review and appraisal of associations with various diseases

Over the last century, benzene has been a well-studied chemical, with some acute and chronic exposures being directly associated with observed hematologic effects in humans and animals. Chronic heavy exposures to benzene have also been associated with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) in humans. Other disease processes have also been studied, but have generally not been supported by epidemiologic studies of workers using benzene in the workplace. Within occupational cohorts with large populations and very low airborne benzene exposures (less than 0.1–1.0 ppm), it can be difficult to separate background disease incidence from those occurring due to occupational exposures. In the last few decades, some scientists and physicians have suggested that chronic exposures to various airborne concentrations of benzene may increase the risk of developing non-Hodgkin’s lymphoma (NHL) (, Am J Ind Med 31:287–295; , Cancer Epidemiol Biomarkers Prev 16:385–391), multiple myeloma (MM) (, Ann NY Acad Sci 609:225–230; , Ann NY Acad Sci 1076:90–109), and various other hematopoietic disorders. We present a state-of-the-science review of the medical and regulatory aspects regarding the hazards of occupational exposure to benzene. We also review the available scientific and medical evidence relating to benzene and the risk of developing various disorders following specific levels of exposure. Our evaluation indicates that the only malignant hematopoietic disease that has been clearly linked to benzene exposure is AML. Information from the recent “Benzene 2009,” a symposium of international experts focusing on the health effects and mechanisms of toxicity of benzene, hosted by the Technical University of Munich, has been incorporated and referenced.
OLFACTORY LEARNING AND BRAIN LESIONS IN THE WOOD ANT (FORMICA RUFA).

Abstract : A technique is described for training ants in a T-maze, using olfactory cues. True olfactory learning occurs and amputation of the antennae prevents the use of olfactory cues. Amputation of one antenna causes a slight falling off in performance, but the ants still perform well above chance level after the operation. After ants have been trained in an olfactory discrimination, the effect of brain lesions on performance is studied. Severing the tracts between both antennal lobes and the alpha lobes of the mushroom bodies causes performance to fall back to chance level. Severing the tracts on only one side of the brain, or lesions placed elsewhere, does not disturb performance. Results are discussed in relation to the involvement of the mushroom bodies and antennal lobes in learning. (Author)
Cavity Optomechanics with a Bose-Einstein Condensate

Cavity optomechanics studies the coupling between a mechanical oscillator and the electromagnetic field in a cavity. We report on a cavity optomechanical system in which a collective density excitation of a Bose-Einstein condensate serves as the mechanical oscillator coupled to the cavity field. A few photons inside the ultrahigh-finesse cavity trigger strongly driven back-action dynamics, in quantitative agreement with a cavity optomechanical model. We approach the strong coupling regime of cavity optomechanics, where a single excitation of the mechanical oscillator substantially influences the cavity field. The results open up new directions for investigating mechanical oscillators in the quantum regime and the border between classical and quantum physics.
Optimizing therapy for newly diagnosed open-angle glaucoma: lessons learned from the Collaborative Initial Glaucoma Treatment Study.

P ATIENTS WITH OPEN-ANGLE GLAUCOMA (OAG) would benefit from the safest, most effective approach to preserve their visual function while maximizing their quality of life. Certainly we owe it to our patients to find the best approach to manage glaucoma using evidence-based medicine. The Collaborative Initial Glaucoma Treatment Study (CIGTS) is a randomized clinical trial that tests whether filtration surgery or medical therapy is the best initial step to treat newly diagnosed OAG. Before this study, there were claims that immediate surgery was superior to medical therapy for patients with newly diagnosed OAG (see the study by Musch et al for a list of references). These studies indicated that a surgery-first approach to glaucoma was associated with lower intraocular pressure (IOP), more favorable visual field outcomes, and lower costs than a medicine-first approach. Furthermore, other studies indicated that long-term medical therapy disrupted the integrity of the ocular surface, potentially jeopardizing the success of filtration surgery should it be required if medical therapy failed. Subsequent advances in medical therapy on the one hand and the widespread use of antimetabolites during glaucoma filtration surgery on the other only added complexity to the “incise” vs “instill” debate.
Adaptive algorithm for impulse noise suppression from still images and its real time implementation

This paper presents a new algorithm to suppress impulse noise in still images, which allows removal of up to 90% noise. The paper is focused on two directions: performance evaluation of the new algorithm comparing with existing algorithms and evaluating the possibility to implement this algorithm in real time, for video clips, using the family of digital signal processors BF5xx signal (Analog Devices Inc.).
Removal of cadmium by combining deferasirox and desferrioxamine chelators in rats

An investigation was conducted to evaluate the ability of two chelators, deferasirox and desferrioxamine (DFO), in removing cadmium from biological system. The potential efficiency of those chelators were investigated after cadmium administration for 60 days following two dose levels of 20 and 40 mg/kg body weight daily to male rats. However, abnormalities were observed in clinical signs after cadmium administration, such as yellowish discoloration of hair, flaccid and hypotonic muscles, irritability, weakness and loss of weight. The hypothesis that the two chelators might be more efficient as combined therapy than single therapy in removing metal ions from the body was considered. In this way, two known chelators, deferasirox and DFO were chosen and tested in the acute rat model. The chelation therapy results show that deferasirox and DFO are able ? to remove cadmium ions from the body, while iron concentration returned to the normal level and symptoms are decreased.
Using phenotypic manipulations to study multivariate selection of floral trait associations.

BACKGROUND A basic theme in the study of plant-pollinator interactions is that pollinators select not just for single floral traits, but for associations of traits. Responses of pollinators to sets of traits are inherent in the idea of pollinator syndromes. In its most extreme form, selection on a suite of traits can take the form of correlational selection, in which a response to one trait depends on the value of another, thereby favouring floral integration. Despite the importance of selection for combinations of traits in the evolution of flowers, evidence is relatively sparse and relies mostly on observational approaches. SCOPE Here, methods for measuring selection on multivariate suites of floral traits are presented, and the studies to date are reviewed. It is argued that phenotypic manipulations present a powerful, but rarely used, approach to teasing apart the separate and combined effects of particular traits. The approach is illustrated with data from studies of alpine plants in Colorado and New Zealand, and recommendations are made about several features of the design of such experiments. CONCLUSIONS Phenotypic manipulations of two or more traits in combination provide a direct way of testing for selection of floral trait associations. Such experiments will be particularly valuable if rooted in hypotheses about differences between types of pollinators and tied to a proposed evolutionary history.
Left ventricular non-compaction cardiomyopathy.

A 30-year-old woman presented with dull left-sided chest pain, radiating to her left arm, lasting seconds on each episode. She denied any palpitations or dyspnoea and had no cardiovascular risk factors or family history of sudden death. A twelve-lead electro cardiogram showed normal sinus rhythm at 70/min with no acute changes. Transthoracic echocardiography revealed normal left ventricular size and function, however, note was made of prominent trabeculations in the left ventricle.
Mercaptopurine metabolite results in clinical gastroenterology practice

Background : Azathioprine (AZA) and its active metabolite mercaptopurine (MP) are frequently used in the management of inflammatory bowel disease. Measurement of the AZA/MP metabolites, thioguanine (TG) and methylmercaptopurine (MMP), has been suggested as a means to optimize therapy with AZA/MP in inflammatory bowel disease.
Application of a Photochromic Dye in an Automatic Welding Filter

The main purposes of this study were to select a photochromic dye and to develop an active welding filter with a photochromic layer. A series of functionalized spirobenzopyranoindolins were synthesized and their photophysical and photochemical properties were investigated in a solution using absorption and emission spectroscopy. Time-resolved fluorescence spectroscopy measurements were used to characterize the decays and rate constants of fluorescence emission. One dye was selected as a suitable photoactive compound in automatic welding filters. A model of an active welding filter with a photochromic layer based on 1’,3’,3’-trimethyl-6-nitrospiro[2H-1-benzopyran-2,2’-indole] (6-nitroBIPS) was developed. The paper presents the results of tests of the filter conducted according to EN standards.
Soil Contamination by Chromium and Its Enzymatic Activity and Yielding

The effect of chromium (VI) on the activity of dehydrogenases, urease, acid and alkaline phosphatases and the yield of lupine was assayed in a pot experiment. Chromium was applied as K2Cr2O7 in the amounts of 0, 10, 20, 30, 40, 50, 100 and 150 in mg · kg -1 of soil. The tests were conducted on brown leached soil from slightly dusty clay sand of pH in 1 M KCl 5.80. Soil was inoculated with nitragine containing Bradyrhizobium bacteria. Hexavalent chromium was found to inhibit the activity of dehydrogenases, urease, acid and alkaline phosphatases and to depress the yield of above-ground parts of lupine, yield of roots, number and weight of root nodules. The negative effect of chromium occurred in both inoculated and non-inoculated soil. The potential biochemical soil fertility index derived from the activity of the soil enzymes and organic carbon content was negatively correlated with the rate of chromium (VI) contamination of soil. On the other hand, the index was positively correlated with the yield of lupine.
Activités halieutiques et activités récréatives dans le cadre d’un espace à protéger : le cas du Parc National de la Mer d’Iroise. Rapport Final.

Le present document constitue le rapport final d’un projet de recherche cofinance par le Programme National d’Environnement Cotier, le Programme National « Espaces proteges » Du Ministere de l’Environnement et du Developpement Durable et la Region Bretagne (au titre d’une bourse de these). Son contenu n’engage que ses auteurs. Le projet « Activites halieutiques et activites recreatives dans le cadre d’un espace a proteger : le cas du Parc National de la Mer d’Iroise » a mobilise, de 2000 a 2004, 19 chercheurs relevant de trois institutions : o Universite de Bretagne Occidentale, IUEM (CEDEM) o Ifremer (SEM et Laboratoire RH de Brest) o Universite de Versailles-Saint-Quentin-en-Yvelines (C3ED)
Adaptive power control for single channel ad hoc networks

Power control for mobile ad hoc networks has received increasing interest from the research community. Power control can be invoked to achieve different objectives, including the most popular goals of either increasing the network throughput by mitigating the effects of interference on a node or ensuring minimal power consumption. We propose a power control algorithm for ad hoc networks to improve network throughput. As such, we study and exploit the correlation that exists between the appropriate transmit power of successive RTS, CTS, DATA and ACK frames and propose an adaptive power control algorithm in the framework of the IEEE 802.11 MAC protocol. In contrast to some alternative approaches, our algorithm operates in a single channel and does not require additional hardware support, which makes it very appropriate for existing IEEE 802.11 based networks.