Miracle-dz/UniFAR-FTUs huggingface dataset:
The evaluation of the synergistic antimicrobial and antibiofilm activity of AamAP1-Lysine with conventional antibiotics against representative resistant strains of both Gram-positive and Gram-negative bacteria

Background and purpose: Antimicrobial resistance toward antibiotics is reaching historical unprecedented levels. There is an urgent and imminent need to develop novel antimicrobial alternatives. Antimicrobial peptides could prove to be a successful group of antimicrobials for drug development. Recently, we have designed a novel synthetic peptide named AamAP1-Lysine. The peptide displayed potent wide-spectrum antimicrobial activities against Gram-positive and Gram-negative bacteria. The purpose of this study is to evaluate the antimicrobial effect of combining AamAP1-Lysine with five different conventional antibiotics each representing a distinct mechanism of action in order to explore the possibility of producing a synergistic mode of action against a resistant strain of Gram-positive and a resistant strain of Gram-negative bacteria. Methodology: The antimicrobial activity of AamAP1-Lysine in combination with five different antibiotics were evaluated for their antimicrobial activity employing standard antimicrobial assays, the synergistic activity of the peptide-antibiotic combinations were evaluated using checkerboard technique in addition to real-time time-kill assays. For the antibiofilm studies, the MBEC values were determined by employing the Calgary device. Results: The combination strategy displayed potent synergistic activities against planktonic bacteria in a significant number of peptide-antibiotic combinations. The synergistic activity managed to reduce the effective minimum inhibitory concentration (MIC) concentrations dramatically with some combinations exhibiting a 64-fold decrease in the effective MIC of AamAP1-Lysine individually. Additionally, the combined synergistic activities of the peptide antibiotics were evaluated, and our results have identified two peptide antibiotic combinations with potent synergistic activities against biofilm growing strains of resistant bacteria. Conclusion: Our results clearly indicate that peptide-antibiotic combinations could prove to be a very effective strategy in combatting multidrug-resistant bacteria and biofilm caused infections.
Acute encephalitis syndrome caused by Orientia tsutsugamushi

Acute encephalitis syndrome (AES) secondary to scrub typhus infection is rarely seen clinically. A 50-year-old man was brought to our emergency department (ED) with weakness, disorientation, and bizarre behavior. An episode of generalized tonic-clonic (GTC) seizure occurred with urine and stool incontinence, and he became unresponsive. Glasgow Coma Scale score was E4V2M4. At ED, a physical examination revealed fever (body temperature: 39.4 ℃), tachycardia (pulse rate: 135 beats per minute), hypotension (systolic/diastolic: 77/61 mmHg), skin rashes over the trunk, disorientation, and two eschar lesions over his right chest wall and thigh, but no focal neurologic deficits. On the 4 th day of admission, real-time polymerase chain reaction test was positive for tsutsugamushi . Finally, he recovered and was discharged 9 days later. Scrub typhus is an acute mite-borne febrile illness caused by Orientia tsutsugamushi . Patients can present with non-specific flu-like symptoms, such as headache, myalgia, cough, nausea, and vomiting. In a scrub typhus emergency, acute febrile illness with central nervous system symptoms require timely diagnosis and treatment to prevent mortality and disease sequelae. This case highlights the need for a high degree of suspicion for AES secondary to scrub typhus to diagnose it early and to start specific treatment immediately. Patients usually recover soon with a good outcome.
ANALISIS PERBAIKAN KUALITAS KERTAS WHITE TOP LINER MENGGUNAKAN METODE FAULT TREE ANALYSIS (FTA), FAILURE MODE AND EFFECT ANALYSIS (FMEA), DAN CRITICALITY ANALYSIS (STUDI KASUS : PT PURA BARUTAMA UNIT PAPER MILL 5)

Kebutuhan kertas terus meningkat hingga 3% tiap tahunnya. Hal ini mendorong produsen kertas untuk menghasilkan produk kertas yang sesuai dengan permintaan konsumen. Namun, terdapat beberapa kendala dalam produksi kertas diantaranya mesin yang menghasilkan produk cacat salah satunya yaitu jenis cacat warna. Oleh karena itu, dibutuhkan suatu kebijakan untuk menyelesaikan penyebab terjadinya cacat warna. Kebijakan ini dapat diperoleh dengan mengidentifikasi penyebab yang paling dominan kemudian merumuskan solusi untuk menyelesaikan penyebab tersebut. Tujuan penelitian ini adalah untuk mengetahui faktor penyebab terjadinya cacat jenis warna, menentukan faktor dominan, serta menentukan kebijakan yang sesuai untuk menyelesaikan penyebab dominan tersebut. Metode yang dilakukan adalah Fault Tree Analysis, Failure Mode and Effect Analysis, dan Criticality Analysis. Objek penelitian adalah unit Paper Mill 5 PT Pura Barutama. Dari hasil pengolahan data dan analisis diperoleh hasil bahwa ada 14 minimal cut-set yang dapat menyebabkan jenis cacat warna. Minimal cut-set yang menjadi fokus untuk diselesaikan selanjutnya yaitu pisau refiner yang tumpul atau rusak . Selanjutnya dilakukan perhitungan criticality index dan didapat nilai sebesar 465 yang berarti kebijakan maintenance komponen yang sesuai yaitu dengan corrective maintenance Abstract [Quality improvement analysis in white top liner paper using Fault Tree Analysis (FTA) and Criticality Analysis (case study: PT Pura Barutama unit Paper Mill 5)] Paper needs continue to increase by 3% annually. This fact encourages paper producers to produce paper products that meet consumer’s increased needs. However, there are some problems in the production of paper such as machines that produce defective products, for example, the color type defects. Therefore, it takes a policy to solve the causes of the occurrence of color defects. This policy can be obtained by identifying the most dominant cause then formulating solutions to solve the cause. The purpose of this study is to determine the factors causing the occurrence of color type defects, determine the dominant factors and determine the appropriate policy to solve the dominant cause. The methods used are Fault Tree Analysis, Failure Mode and Effect Analysis, and Criticality Analysis. The object of research is Unit Paper Mill 5 PT Pura Barutama. After processing and analyzing the data, the result is there are 14 minimum cut-set that can cause color type defects. Minimum cut-set that becomes the focus to be resolved is blunt or damaged refiner blade. Furthermore, the calculation of the criticality index for the minimum cut-set result a value of 465 which means the appropriate maintenance policy is corrective maintenance.
Evaluation of quality of antenatal care services in selected healthcare centres of Mumbwa and Lusaka districts of Zambia: Pregnant womens perspectives

Antenatal care (ANC) has been recommended as a service that can reduce both maternal and newborn mortalities. However, even in areas recording high ANC attendance, there are unevenly high levels of maternal and new born mortalities. Evidence of a weak relationship between ANC use and maternal and newborn survival has motivated recent calls to focus on content and quality of care provided rather than mere ANC attendance. This was a descriptive cross sectional study which was designed to evaluate the quality of antenatal care services in two health facilities in Lusaka and two in Mumbwa districts of Zambia. The health facilities were selected purposively based on poor maternal outcomes such as high maternal mortality ratio. Women attending antenatal clinics were selected using simple random sampling. Data was collected using a client exist interview schedule designed by World Health Organization for assessing quality of antenatal care. Data was analyzed using Statistical Package for Social Scientist (SPSS) version 24.0. The study revealed a lot of variations in the care provided at the four sites. None of the women had all the blood tests for haemoglobin, grouping and X-match, HIV and syphilis conducted from three out of the four health facilities, while at the fourth, only 30% of women had all the blood tests conducted. Furthermore, less than 20% of women had a full head to toe examination. While less than 10% of women from each of the facility reported that the health providers met the requirements for provision of privacy. Despite not meeting the minimum standards of care, only less than 5% of women categorized the care as poor. All the four health facilities recorded low quality of care on all domains of antenatal care. Therefore, if antenatal care has to achieve its intended purpose of reducing adverse maternal and new born outcomes, then quality of care delivered during pregnancy should be the focus as opposed mere attendance. Key words: Quality, antenatal care services, evaluation.
The effect of certification and accreditation on quality management in 4 clinical services in 73 European hospitals

Objective To investigate the relationship between ISO 9001 certification, healthcare accreditation and quality management in European hospitals. Design A mixed method multi-level cross-sectional design in seven countries. External teams assessed clinical services on the use of quality management systems, illustrated by four clinical pathways. Setting and Participants Seventy-three acute care hospitals with a total of 291 services managing acute myocardial infarction (AMI), hip fracture, stroke and obstetric deliveries, in Czech Republic, France, Germany, Poland, Portugal, Spain and Turkey. Main Outcome Measure Four composite measures of quality and safety [specialized expertise and responsibility (SER), evidence-based organization of pathways (EBOP), patient safety strategies (PSS) and clinical review (CR)] applied to four pathways. Results Accreditation in isolation showed benefits in AMI and stroke more than in deliveries and hip fracture; the greatest significant association was with CR in stroke. Certification in isolation showed little benefit in AMI but had more positive association with the other conditions; greatest significant association was in PSS with stroke. The combination of accreditation and certification showed least benefit in EBOP, but significant benefits in SER (AMI), in PSS (AMI, hip fracture and stroke) and in CR (AMI and stroke). Conclusions Accreditation and certification are positively associated with clinical leadership, systems for patient safety and clinical review, but not with clinical practice. Both systems promote structures and processes, which support patient safety and clinical organization but have limited effect on the delivery of evidence-based patient care. Further analysis of DUQuE data will explore the association of certification and accreditation with clinical outcomes.
Natural Killer (NK) Cell Alloreactivities against Leukemic Cells: Functions beyond Defense

Immunotherapy using adoptive transfer of natural killer (NK) cells has progres-sively been utilized in hematologic malignancies over the past decade. Presently, NK cell immunotherapy has been promising and feasible in acute leukemia, particularly in acute myeloblastic leukemia (AML). Alloreactive NK cells have been exploited under the killer immunoglobulin-like receptor (KIR)-ligand mismatches between donors and recipients in haploidentical hematopoietic stem cell transplantation (haplo-HSCT) after immunosuppressive chemotherapy. Of interest, alloreactive NK cells killed residual leukemic cells, dendritic cells (DCs) and T cells in acute leukemia patients and led to significantly improved clinical outcomes. Consequently, this chapter provides the KIR genetics and the mechanisms of alloreactive NK cells that are shown to be crucial in the successful therapy of acute leukemia (myeloid and lymphoid). Altogether, the donor selection algorithm of haplo-HSCT is discussed to emphasize the importance and give priority to increase the chances of therapy success. These will be useful for students and researchers who work in immunogenetics. Furthermore, the knowledge would be applicable to clinical research and medical sciences.
Preparation and Electrochemical Performance of CMF High Voltage Cathode Material for Lithium Ion Battery

In this paper, based on CMF high voltage and liquid precipitation method, the ternary precursor is prepared; then by mixing it with lithium carbonate, the analysis is made for their properties through the XRD and thermogravimetry; finally, the ternary cathode material of lithium ion battery is prepared under the high temperature reaction for the mixture of the precursors and lithium carbonate, and the electrochemical properties of the material are investigated. The oxidative dehydration process of the ternary precursor is mainly concentrated at 250°C-350°C under the CMF high voltage. As the temperature increases to 200°C and 300°C respectively, the ternary precursors are developed into Me(OH) 2 and CoNiOOH structures respectively; as the temperature further increases CoNiOOH was anhydrated into Mn (Ni, Co) 2O4, and the material surface becomes very dense; at 300-500°C, the mixture shows the characteristics of the composite oxide (LiNi0.5Co0.2Mn0.3O2); at 600°C above, the diffraction peak belonging to lithium carbonate completely disappears, and LiNi0.5Co0. 2Mn0.3O2 is basically generated. The electrochemical analysis of LiNi0.5Co0. 2Mn0.3O2 shows that the maximum specific capacity of the battery for the first charge and discharge is 172 mAh/g, and the Coulomb efficiency is 90.1%. When the lithium content in the material is set to be 1.09, the battery parameters such as median voltage and discharge platform all reach the optimal value.
Climbing the corporate ladder: desired leadership skills and successful psychopaths

Purpose Many of the characteristics embodied by successful psychopaths, such as superficial charm, cool decisiveness and a grandiose self-worth, are often treated synonymously with corporate leadership qualities. Consequently, it is possible that successful psychopaths are actively being selected for corporate positions as they exemplify the perfect candidate. The purpose of the current study was to determine whether or not the recruitment for positions of higher social status are inadvertently seeking out individuals with psychopathic tendencies to run their companies using similar characteristics in their job advertisements. Design/methodology/approach The current study will provide a deeper understanding of successful psychopaths whilst exploring the role of the “Westernized” corporation in recruiting successful psychopaths into their businesses through character descriptions in 25 executive career advertisements using Wexler’s (2008) psychopathic Personality Dimensions And Positively Reinforced Corporate Labels. Findings The results demonstrated that corporations are seeking out characteristics that are synonymous to Factor 1 psychopathic personality traits, which could increase the propensity of successful psychopaths in the workplace. Research limitations/implications Although the sample was representative for the current study, the sample size is minimal. Further, most companies in the sample were taken from the public sector. Given the implicit sample bias, the results and conclusions must be interpreted with caution. Future research should expand the relationship between psychopathic personality traits and corporate labels in a broader context. Practical implications The results also allude to potential protective factors that could be put in place by corporations during their hiring process. These factors include measures for empathy and emotional IQ. Beyond the hiring process, it is suggested that incentive-based promotions should be lessened and replaced with incentives that promote care and respect for one another. Social implications Whilst the inability for the public to conceptualize white-collar crime as a true form of crime conducted by powerful individuals is apparent, it is suggested that change should begin with public awareness and academia. With additional research on psychopathy in the field of criminology and organizational psychology, public awareness can be amplified. Originality/value The current study allows for an interdisciplinary perspective towards the concept of successful psychopathy by highlighting the increased potential for corporate scams and white-collar criminality. Specifically, the current study introduces a psycho-social criminological perspective.
Performance calculation for a high speed solid-rotor induction motor

The paper deals with analytical method of design and prediction of performance characteristics for induction motors with solid steel rotor coated with copper layer. On the basis of the distribution of the 2D electromagnetic field, the equivalent impedance of the rotor have been derived. The edge effect and nonlinear magnetic permeability of solid steel have been included. The presented analytical method has been verified with laboratory test results. A 300 kW, 60 000-rpm, three-phase solid rotor induction motor for air compressor has been investigated. The accuracy of analytical approach is acceptable and can be recommended for rapid design of solid rotor induction motors.
Generalized "Yoking-Proofs" for a Group of RFID Tags

Recently Ari Juels suggested a "yoking-proof" where a pair of radio-frequency identification (RFID) tags are both read within a specified time bound, and left open for future research the problem of generating a proof for larger groups of tags. We generalize his protocol by developing a proof which ensures that a group of tags is read within a certain time period. The tags generate such a proof even if the reader is untrusted. The proof is improbable to forge, and is verifiable off-line by a trusted verifier. Juels' problem formulation does not lake privacy into account and the resulting protocol offers no privacy to the tags. We modify the problem statement to require the "yoking-proof" to maintain privacy, and we give a protocol for this new anonymous yoking problem, along with suggestions for speed ups
Programming semantics for multiprogrammed computations

The semantics are defined for a number of meta-instructions which perform operations essential to the writing of programs in multiprogrammed computer systems. These meta-instructions relate to parallel processing, protection of separate computations, program debugging, and the sharing among users of memory segments and other computing objects, the names of which are hierarchically structured. The language sophistication contemplated is midway between an assembly language and an advanced algebraic language.
Emerging Sign Languages of Mesoamerica

Abstract:In this article, I briefly explore recent investigations regarding the emergence of sign languages in Mesoamerican contexts and examine some features that facilitate their emergence. In recent years, many studies have been documenting emerging sign languages around the world. Mesoamerica provides an interesting comparative field, since several of these sign languages appeared within the Mayan area while others emerged in communities belonging to a different spoken language family. A comparison based on the first available reports and studies conducted in this area reveals that there are many similarities but also crucial differences clearly linked to the cultural and linguistic backgrounds of the surrounding communities in which these sign languages emerged. Prominent features that help and, to some extent, shape the sign language are the use of multimodal communication in the surrounding hearing community (i.e., the significant use of conventional gestures and nonverbal behaviors), the (positive) attitude toward deafness, and the shared material culture as well as cultural and communicative practices. Also, contexts of sign language use vary according to the type of speech community. For instance, there will be differences in terms of vocabulary size and degrees of conventionalization between homesign systems or sign systems (with one deaf individual), village sign languages (with multiple deaf individuals with a shared background), and community sign languages (with multiple deaf individuals without a shared background) (Meir et al. 2012).
An improved switched injection-locked oscillator for ranging and communication systems

This paper describes an improved integrated switched injection-locked oscillator (SILO) circuit for use in pulsed angular modulated ultra wideband communication and radar systems, implemented in a 0.25 μm SiGe:C BiCMOS technology. The circuit consists of two active baluns for single-ended to differential and differential to single-ended conversion, a Schmitt-trigger with two pulse generators based on current-starved voltage controlled delay lines and inverter chains and a simple Q-degenerated cross-coupled oscillator for signal generation. It has an externally controllable pulse repetition rate and duration. The previous works of the authors [1] was severely improved in the area of required locking power and pulse duration control. Required injection power has been reduced to -65 dBm. During operation it consumes combined 40mA from 3.3V analog and 2.5V digital supply voltage, while generating a 370mVpp signal. The generated signal has a 10 dB-bandwidth ofs over 2.3 GHz at 6.8 GHz center frequency. Measurement results are shown.
High quality factor micromachined toroid and solenoid inductors

High quality toroid and solenoid inductors, exhibiting quality factors as high as 87 at 14.5 GHz and 35 at 6.4 GHz are presented in this paper. The inductors are fabricated using only two plating steps which reduces the complexity of the fabrication. The process lowers the number of ohmic contacts between the electroplated layers improving the performance of the device. The fabrication process is low-temperature and fully compatible with CMOS technology which makes it suitable for post-IC processing.
Modelado Dinámico y Control de un Tractor Articulado con Implemento

El presente trabajo lleva adelante un análisis de un tractor articulado con dirección delantera acoplado a un implemento agrícola (como ser una fumigadora o una sembradora). Se desarrolla aquí el modelo de este sistema, en primer lugar en términos cinemáticos y luego en términos dinámicos. Utilizando la técnica de control predictivo, se calculan las acciones de control que permiten al implemento recorrer una trayectoria de referencia. Se emplean simulaciones numéricas para ilustrar el comportamiento del sistema y del controlador implementado.
A privacy‐preserving framework for smart context‐aware healthcare applications

Smart connected devices are widely used in healthcare to achieve improved well‐being, quality of life, and security of citizens. While improving quality of healthcare, such devices generate data containing sensitive patient information where unauthorized access constitutes breach of privacy leading to catastrophic outcomes for an individual as well as financial loss to the governing body via regulations such as the General Data Protection Regulation. Furthermore, while mobility afforded by smart devices enables ease of monitoring, portability, and pervasive processing, it introduces challenges with respect to scalability, reliability, and context awareness. This paper is focused on privacy preservation within smart context‐aware healthcare emphasizing privacy assurance challenges within Electronic Transfer of Prescription. We present a case for a comprehensive, coherent, and dynamic privacy‐preserving system for smart healthcare to protect sensitive user data. Based on a thorough analysis of existing privacy preservation models, we propose an enhancement to the widely used Salford model to achieve privacy preservation against masquerading and impersonation threats. The proposed model therefore improves privacy assurance for smart healthcare while addressing unique challenges with respect to context‐aware mobility of such applications.