Miracle-dz/UniFAR-FTUs huggingface dataset:
Autophagy and cardiac diseases: Therapeutic potential of natural products

The global incidence of cardiac diseases is expected to increase in the coming years, imposing a substantial socioeconomic burden on healthcare systems. Autophagy is a tightly regulated lysosomal degradation mechanism important for cell survival, homeostasis, and function. Accumulating pieces of evidence have indicated a major role of autophagy in the regulation of cardiac homeostasis and function. It is well established that dysregulation of autophagy in cardiomyocytes is involved in cardiac hypertrophy, myocardial infarction, diabetic cardiomyopathy, and heart failure. In this sense, autophagy seems to be an attractive therapeutic target for cardiac diseases. Recently, multiple natural products/phytochemicals, such as resveratrol, berberine, and curcumin have been shown to regulate cardiomyocyte autophagy via different pathways. The autophagy‐modifying capacity of these compounds should be taken into consideration for designing novel therapeutic agents. This review focuses on the role of autophagy in various cardiac diseases and the pharmacological basis and therapeutic potential of reported natural products in cardiac diseases by modifying autophagic processes.
Serum 14-3-3η is a Marker that Complements Current Biomarkers for the Diagnosis of RA: Evidence from a Meta-analysis

ABSTRACT Objective To systematically evaluate the diagnostic value of 14-3-3η protein for rheumatoid arthritis (RA). Method Searched PubMed, Web of Science, Embase and China Biology Medicine (CBM) databases comprehensively from inception to May 2020. The evaluation index were the pooled sensitivity, specificity, diagnosis odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR), as well as the area under the summary receiver operating characteristic (SROC) curves. Meta-Disc 1.4 and RevMan 5.3 were used to analyze all statistics. QUADAS-2 tool was applied to evaluate the quality of eligible studies. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Results Nine articles containing eleven records were eligible for this meta-analysis. The pooled sensitivity of 14-3-3η was 0.63 (95% CI: 0.60 to 0.66), the pooled specificity was 0.90 (95% CI: 0.88 to 0.91). The pooled PLR and NLR was 6.10 (95% CI: 4.67 to 7.96) and 0.40 (95% CI: 0.33 to 0.48), respectively. The pooled DOR was 15.90 (95% CI: 11.15 to 22.68), and the area under the curve (AUC) was 0.8696. Compared with a single indicator (rheumatoid factor or anti-citrullinated protein antibodies), adding 14-3-3η can bring incremental benefits to the diagnosis of RA. The results of subgroup analysis and meta-regression suggested that the two factors (ethnicity, early vs established RA) we analyzed might not be the source of heterogeneity (P value were 0.0979 and 0.4298, respectively) and there was no publication bias among these articles (P = .42). Conclusion Serum 14-3-3η protein is a supplementary biomarker in the diagnosis of RA.
Predictors of Bleeding in the Perioperative Anticoagulant Use for Surgery Evaluation Study

Background In the PAUSE (Perioperative Anticoagulant Use for Surgery Evaluation) Study, a simple, standardized, perioperative interruption strategy was provided for patients with nonvalvular atrial fibrillation taking direct oral anticoagulants (DOACs). Our objective was to define the factors associated with perioperative bleeding. Methods and Results We analyzed bleeding as the composite of major and clinically relevant nonmajor bleeding. Putative predictors of bleeding, and preoperative DOAC level were prospectively collected during recruitment. We used stratified logistic regression models for analysis. All statistical analyses were performed in R version 3.6. 0. There were 3007 patients requiring perioperative DOAC interruption. More than one third of the included patients underwent a high bleeding risk procedure. The 30‐day rates of major and clinically relevant nonmajor bleeding were 3.02% in apixaban (n=1257), 2.84% in dabigatran (n=668), and 4.16% for rivaroxaban (n=1082). Multivariate analysis stratified by region found more bleeding for hypertension (odds ratio [OR], 1.79; 95% CI 1.07‐2.99; P=0.027), and prior bleeding (OR, 1.71; 95% CI, 1.08‐2.71; P=0.021). Surgical bleed risk classification (high‐ versus low‐risk) as a predictor of bleeding was only significant in the univariate analysis. The prediction model for major and clinically relevant nonmajor bleeding had an area under the curve of 0.71, and the preoperative DOAC level did not improve the area under the curve of the model. Conclusions In patients treated with DOACs who required an elective surgery/procedure and were managed with standardized DOAC interruption and resumption, there we did not find reversible risk factors for bleeding, suggesting that adjustment of the PAUSE management protocol to mitigate against bleeding is not needed.
Neoadjuvant Chemotherapy in Pancreatic Cancer: An Appraisal of the Current High-Level Evidence

At the time of diagnosis, only about 20% of patients with pancreatic ductal adenocarcinoma (PDAC) have resectable disease. PDAC treatment necessitates a multidisciplinary approach, and adjuvant chemotherapy after upfront resection is an established means of preventing recurrence. Neoadjuvant chemotherapy (NAT), originally introduced to downstage tumor size, is nowadays more frequently used for selection of patients with favorable tumor biology and to control potential micrometastases. While NAT is routinely applied in locally advanced (LA) PDAC, there is increasing evidence demonstrating benefits of NAT in borderline resectable (BR) PDAC. The concept of NAT has recently been tested in resectable PDAC, but to date NAT has been restricted to clinical trials, as the data are limited and no clear benefits have yet been shown in this patient group. This review summarizes the current evidence for NAT in resectable, BR, and LA PDAC, with a focus on high-level evidence and randomized controlled trials.
Cross-compatibility of the Parents as the Main Factor for Successful Olive Breeding Crosses

Previous analyses of olive (Olea europaea L.) crosses have revealed an important degree of pollen contamination. For this reason, the authors tested the paternity of a set of progenies coming from crosses among differentcultivarswithintheolivebreedingprogramofC´ ordoba,Spain,usingfourpolymorphicmicrosatellites.They found that the expected pollen sired 141 (83.4%) of the 169 samples analyzed. The contamination rate was either almost total or almost null within each particular cross considered, not being comparable between different crosses. In a second experiment the authors evaluated the influence of several factors on the success of olive crosses, the type of isolation bag, the timing and number of pollinations, and the cross-compatibility of the parents in a multifactorial assay in 2003. They observed no differences in the type of pollination bag used or the number and timing of pollen additions when they analyzed 145 seeds. The main factor affecting the success of the crosses seems to be the intercompatibility among cultivars, because it had a significant influence on the rate of contamination. In the failed crosses, the authors clearly detected the contribution of more than one cultivar to the paternity. The results obtained here indicate that some knowledge of cross-compatibility relationships in olive is required to design crosses in olive breeding programs effectively. To achieve this objective, the progeny parentage analysis could be of great help because of the high level of pollen contamination found among those studied here.
Analysis and impact of a multidisciplinary lymphoma virtual tumor board

Abstract The aim is to prospectively evaluate the impact of a multidisciplinary lymphoma virtual tumor board. The utility of multi-site interactive lymphoma-specific tumor boards has not been reported. The Mayo Clinic Lymphoma Tumor Board is a component of the International Mayo Clinic Care Network (MCCN). The format includes the clinical case presentation, presentation of radiology and hematopathology findings by the appropriate subspecialist, proposed treatment options, review of the literature pertinent to the case, pharmacy contributions, and discussion followed by recommendations. Three hundred and nine consecutive highly selected real-time cases with a diagnosis of lymphoma were presented at the Mayo Clinic Lymphoma Tumor Board from January 2014 to June 2018 and decisions were prospectively tracked to assess its impact on the treatment decisions. A total of 309 cases were prospectively evaluated. One hundred and forty (45.3%) cases had some changes made or recommended. The total changes suggested were 179, as some cases had more than one recommendation. There were 93 (30%) clinical management recommendations, 45 (14.6%) additional testing recommendations, 29 (9.4%) pathology changes, and 6 (1.9%) radiology changes. In an electronic evaluation process, 93% of the responders reported an improvement in knowledge and competence, and 100% recommended no change in format of the board. A multidisciplinary lymphoma tumor board approach was found to have a meaningful impact on lymphoma patients while enhancing interdisciplinary interactions and education for multiple levels of the clinical care team.
Navigation of Silver/Carbon Nanoantennas in Organic Fluids Explored by a Two-Wave Mixing

Within this work are analyzed third-order nonlinear optical properties with a potential influence on the dynamic mechanics exhibited by metal/carbon nanofluids. The nanofluids were integrated by multiwall carbon nanotubes decorated with Ag nanoparticles suspended in ethanol or in acetone. Optical third-order nonlinearities were experimentally explored by vectorial two-wave mixing experiments with a Nd-YAG laser system emitting nanosecond pulses at a 532 nm wavelength. An optically induced birefringence in the metal/organic samples seems to be responsible for a significant modification in density and compressibility modulus in the nanosystems. The measured nonlinear refractive index was associated with a thermal process together with changes in density, compressibility modulus and speed of sound in the samples. Nanofluid diffusivity was studied to characterize the dynamic concentration gradients related to the precipitation of nanostructures in the liquid solutions. The evolution of the nanoparticle density suspended in the nanofluids was considered as a temporal-resolved probabilistic system. It is stated that the incorporation of Ag nanoparticles in carbon nanotubes produces strong mechanical changes in carbon-based nanofluids. According to numerical simulations and optical evaluations, immediate applications for developing dynamic nanoantennas optical logic gates and quantum-controlled metal/carbon systems can be contemplated.
Effects of mindfulness training on posttraumatic stress symptoms from a community-based pilot clinical trial among survivors of intimate partner violence.

Objective: Exposure to intimate partner violence (IPV) is a significant public health issue associated with deleterious mental and medical health comorbidities, including posttraumatic stress disorder (PTSD). The hallmark symptoms of posttraumatic stress (PTS), even when not meeting the threshold for a diagnosis of PTSD, appear to be underpinned by poor self-regulation in multiple domains, including emotion, cognitive control, and physiological stress. Mindfulness-based stress reduction (MBSR) holds promise for treating PTS symptoms because evidence suggests it targets these domains. The current study was a pilot randomized clinical trial designed to examine changes in emotion regulation, attentional function, and physiological stress dysregulation among women IPV survivors with elevated PTS symptoms after participation in a group-based, 8-week MBSR program. Method: In total, 29 participants were randomized to receive MBSR (n = 19) or an active control (n = 10). Assessments were conducted at study entry, as well as 8 and 12 weeks later. Results: Between-group differences on primary outcomes were nonsignificant; however, when exploring within groups, statistically significant decreases in PTS symptoms, F(1.37, 16.53) = 5.19, p < . 05, and emotion dysregulation, F(1.31, 14.46) = 9.36, p < . 01, were observed after MBSR but not after the control intervention. Further, decreases in PTSD and emotion dysregulation were clinically significant for MBSR participants but not control participants. Conclusions: These preliminary data signal that MBSR may improve PTS symptoms and emotion regulation and suggest further study of the effectiveness of PTSD interventions guided by integrative models of MBSR mechanisms and psychophysiological models of stress regulation. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Raising the threshold for hospital admission and endoscopy in upper gastrointestinal bleeding during the COVID-19 pandemic

Upper gastrointestinal bleeding (UGIB) is a common cause of hospital admissions worldwide. While health care systems are under significant strain during the COVID-19 pandemic, it is logical to reduce hospital admissions for patients at very low risk of poor outcomes. Additionally, upper gastrointestinal endoscopy is recognized as an aerosol-generating procedure that should be restricted during the pandemic, because of the risk of spreading COVID-19 and the limited availability of personal protection equipment [1, 2]. Therefore, elective and even urgent endoscopy has been suspended in many centers worldwide. Current guidelines recommend the use of the Glasgow-Blatchford Score (GBS) for predicting the need for hospital-based intervention in patients with UGIB [3, 4]. Patients with GBS ≤1 are recognized to be at very low risk and can safely be managed as outpatients with no need for inpatient endoscopy [3, 4]. Based on data from a large international multicenter study including 3012 consecutive patients with UGIB [5], we have evaluated the outcomes associated with extended low risk GBS thresholds for identifying patients needing hospital admission and endoscopic therapy. ▶Table 1 shows the numbers of identified low-risk patients and outcomes for GBS thresholds 0 to ≤5.Use of GBS ≤2 or ≤3 as thresholds for avoiding hospital admission in UGIB would lead to avoidance of admission and in-hospital endoscopy in 26%–32% of all UGIB patients. In patients classified as being at low risk, the risk of needing endoscopic therapy (3.3%–4.1%), needing surgery or embolization (0.5%), death within 30 days (0.8%–1.7%), and delayed identification of upper gastrointestinal cancer (0.65%– 0.75%) would probably be acceptable in countries with a health care system facing significant strain or potential collapse from COVID-19. If such patients are admitted for other reasons, the very low risk of needing endoscopic therapy suggests endoscopy could be undertaken electively as an outpatient. Consistently with these suggested thresholds, re-analysis of data from a multicenter study of 1555 patients with UGIB found endoscopic therapy was required in 4.2%–4.4% patients with GBS 2 or 3, but rose to 9.4% for GBS 4 [6]. Combining extended GBS thresholds with exclusion of patients with major risk factors including systolic blood pressure <100mmHg, syncope, or liver cirrhosis was not superior to use of GBS ≤2–3 alone. However, clinical judgment would still be required for specific patients. In countries severely affected by COVID19, we suggest that the low risk threshold for defining UGIB patients who require hospitalization and inpatient endoscopy could be raised to GBS ≤2 or even GBS ≤3. These patients could be treated with high dose oral proton pump inhibitors and evaluated with endoscopy once the epidemic has peaked.
Surgical Treatment of Refractory Medium Macular Hole with Autologous Lens Capsular Flap Transplantation: A Case Report.

PURPOSE To report the clinical results of lens capsular ﬂap (LCF) transplantation in a patient with refractory medium macular hole (MH). METHODS Case report. RESULTS A 66-year-old female myopic patient with a history of medium macular hole (MH) was previously unsuccessfully treated by vitrectomy surgery, internal limiting membrane (ILM) peeling and air-fluid exchange followed by 12% C2F6 tamponade into the vitreous cavity and face-down positioning. After the first surgery, the patient's visual acuity of the left eye remained only 20/400 on the Snellen scale, and a persistent medium MH (290 µm) was observed on optical coherence tomography. Cataract of the left eye was also noted. A second surgery, combined cataract-vitrectomy surgery, was carried out to seal the MH, performed under retrobulbar anesthesia. Because there was insufficient ILM tissue to perform the ILM flap procedure, we decided to use another technique involving an autologous LCF. The patient underwent LCF placement onto the MH along with gas tamponade. At 6 months, the MH was sealed, and the patient's vision had improved to 20/32 on the Snellen scale. CONCLUSION This is the first case report to describe the use of LCF to treat persistent medium MH. LCF seems to be effective in sealing small macular holes and was well tolerated by the patient.
Underground Coal Mine Fingerprint Positioning Based on the MA-VAP Method

The access points (APs) in a coal mine wireless local area network (WLAN) are generally sparsely distributed. It can, with difficulty, satisfy the basic requirements of the fingerprint positioning based on Wi-Fi. Currently, the effectiveness of positioning is ensured by deploying more APs in an underground tunnel, which significantly increases system cost. This problem can be solved by using the Virtual Access Point (VAP) method that introduces virtual access points (VAPs), which can be virtually arranged in any part of the positioning area without installing actual access points. The drawback of the VAP method is that the generated received signal strength (RSS) value of a VAP is calculated based on the mapping of RSS value from only one corresponding access point (AP). This drawback does not consider the correlation between different AP signals and the generated RSS value of a VAP, which makes the modeling of fingerprint samples and real-time RSS collection incomplete. This study proposed a Multi-Association Virtual Access Point (MA-VAP) method takes into account the influence of multi-association. The multi-association coefficient is calculated based on the correlation between the RSS values of a VAP and multiple access points (APs). Then, the RSS value generated by a VAP is calculated using the multi-association function. The real-time collected RSS values from multiple APs related to this VAP are the input of the multi-association function. The influence of the number of VAPs and their arrangement on positioning accuracy is also analyzed. The experimental positioning results show that the proposed MA-VAP method achieves better positioning performance than the VAP method for the same VAP arrangement. Combined with the Weight K-Nearest Neighbors (WKNN) algorithm and Kernel Principal Component Analysis (KPCA) algorithm, the positioning error of the MA-VAP method of the error distance cumulative distribution function (CDF) at 90% is 4.5 m (with WKNN) and 3.5 m (with KPCA) in the environment with non-line-of-sight (NLOS) interference, and the positioning accuracy is improved by 10% (with WKNN) and 22.2% (with KPCA) compared with the VAP method. The MA-VAP method not only effectively solves the fingerprint positioning problem when APs are sparse deployed, but also improves the positioning accuracy.
Immune Checkpoints in Viral Infections

As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system escape mechanism. Although immune checkpoint therapy has been successfully used in cancer treatment, numerous studies have suggested that such therapy may also be highly relevant for treating viral infection, especially chronic viral infections. However, it has not yet been applied in this manner. Here, we reviewed recent findings regarding immune checkpoints in viral infections, including COVID-19, and discussed the role of immune checkpoints in different viral infections, as well as the potential for applying immune checkpoint blockades as antiviral therapy.
Phrenic nerve stimulation during right ventricular outflow tract pacing: A rare but possible complication

Phrenic nerve stimulation (PNS) caused by a right ventricular (RV) lead is an uncommon complication of pacemaker implantations. We demonstrated a case of left PNS caused by an RV lead placed in the RV outflow tract (RVOT). The PNS was dependent on ventricular capture. This case highlighted a risk of PNS even during RVOT pacing.
Antibiotic resistance in Campylobacter

Antibiotic resistance has now emerged globally among thermophilic Campylobacter, including Campylobacter jejuni and Campylobacter coli, giving rise to speculation about what has triggered the development of this resistance. This review will focus on the association between antimicrobial use in food animals and the development of resistance in human isolates. The use of antimicrobial agents in food animals has caused concern regarding its impact on human health; there exists a close association between the amounts of antibiotics used and the levels of resistance, and the situation seems to be deteriorating more rapidly. By studying gene diversity of resistance patterns, some of the genetic determinants of antimicrobial resistance may prove useful as epidemiological markers. Resistance has been proved to be caused by the mutations in genes encoding the drugs’ target enzymes, in genes encoding a multidrug efflux pump, as well as in 23S recombinant DNA of Campylobacter. In addition, horizontal genetic exchange is an important cause of antibiotic resistance in Campylobacter strains.