Miracle-dz/UniFAR-FTUs huggingface dataset:
Machine Learning Models to Predict Childhood and Adolescent Obesity: A Review

The prevalence of childhood and adolescence overweight an obesity is raising at an alarming rate in many countries. This poses a serious threat to the current and near-future health systems, given the association of these conditions with different comorbidities (cardiovascular diseases, type II diabetes, and metabolic syndrome) and even death. In order to design appropriate strategies for its prevention, as well as understand its origins, the development of predictive models for childhood/adolescent overweight/obesity and related outcomes is of extreme value. Obesity has a complex etiology, and in the case of childhood and adolescence obesity, this etiology includes also specific factors like (pre)-gestational ones; weaning; and the huge anthropometric, metabolic, and hormonal changes that during this period the body suffers. In this way, Machine Learning models are becoming extremely useful tools in this area, given their excellent predictive power; ability to model complex, nonlinear relationships between variables; and capacity to deal with high-dimensional data typical in this area. This is especially important given the recent appearance of large repositories of Electronic Health Records (EHR) that allow the development of models using datasets with many instances and predictor variables, from which Deep Learning variants can generate extremely accurate predictions. In the current work, the area of Machine Learning models to predict childhood and adolescent obesity and related outcomes is comprehensively and critically reviewed, including the latest ones using Deep Learning with EHR. These models are compared with the traditional statistical ones that used mainly logistic regression. The main features and applications appearing from these models are described, and the future opportunities are discussed.
A new function for torpor: fat conservation in a wild migrant hummingbird

Laboratory studies of torpor in small endotherms suggest hat body temperature is lowered periodically only when the animal is energetically stressed. Almost no data exist on the use and importance of torpor outside laboratory situations. We have monitored the daily energy state of hummingbirds in the field. A rare observation of a torpid individual whose energy state and ecological situation were well-documented showed that migrant hummingbirds may use torpor when they are very fat and not presently energetically stressed. In this case, torpor may be a mechanism to conserve the energy stored for later use on migration.
Habitat use by the porcupine caribou herd during predicted insect harassment

Harassment of female caribou (Rangifer tarandus) by insects may negatively affect the cows' energy balance during the critical post-calving and lactation period, and certain habitats may provide relief from such harassment. Consequently, we tracked adult, female caribou from the Porcupine Caribou Herd (PCH) by satellite between 25 june and 31 july 1985-89 to determine their habitat preferences during periods of predicted harassment by insects, primarily mosquitoes (Culicidae). When insect harassment was predicted (ambient temperatures ≥13C and winds <6 m/sec) dry prostrate dwarf scrub vegetation type was preferred by caribou
Narrative Review on Health-EDRM Primary Prevention Measures for Vector-Borne Diseases

Climate change is expanding the global at-risk population for vector-borne diseases (VBDs). The World Health Organization (WHO) health emergency and disaster risk management (health-EDRM) framework emphasises the importance of primary prevention of biological hazards and its value in protecting against VBDs. The framework encourages stakeholder coordination and information sharing, though there is still a need to reinforce prevention and recovery within disaster management. This keyword-search based narrative literature review searched databases PubMed, Google Scholar, Embase and Medline between January 2000 and May 2020, and identified 134 publications. In total, 10 health-EDRM primary prevention measures are summarised at three levels (personal, environmental and household). Enabling factor, limiting factors, co-benefits and strength of evidence were identified. Current studies on primary prevention measures for VBDs focus on health risk-reduction, with minimal evaluation of actual disease reduction. Although prevention against mosquito-borne diseases, notably malaria, has been well-studied, research on other vectors and VBDs remains limited. Other gaps included the limited evidence pertaining to prevention in resource-poor settings and the efficacy of alternatives, discrepancies amongst agencies’ recommendations, and limited studies on the impact of technological advancements and habitat change on VBD prevalence. Health-EDRM primary prevention measures for VBDs require high-priority research to facilitate multifaceted, multi-sectoral, coordinated responses that will enable effective risk mitigation.
Emotion Variation from Controlling Contrast of Visual Contents through EEG-Based Deep Emotion Recognition

Visual contents such as movies and animation evoke various human emotions. We examine an argument that the emotion from the visual contents may vary according to the contrast control of the scenes contained in the contents. We sample three emotions including positive, neutral and negative to prove our argument. We also sample several scenes of these emotions from visual contents and control the contrast of the scenes. We manipulate the contrast of the scenes and measure the change of valence and arousal from human participants who watch the contents using a deep emotion recognition module based on electroencephalography (EEG) signals. As a result, we conclude that the enhancement of contrast induces the increase of valence, while the reduction of contrast induces the decrease. Meanwhile, the contrast control affects arousal on a very minute scale.
The Effects of Number of Fire Dispatches and Other Situational Factors on Voluntary Exercise Training Among Korean Firefighters: A Multilevel Logistic Regression Analysis

According to previous research, participation in exercise training (ET) by South Korean firefighters varies with shift type, and the effect of shift type is greater in large cities than in small towns. However, shift types differ among regions, depending on the number of dispatches. Therefore, the present study examined the impact of the number of fire dispatches and other situational factors on ET. A series of multilevel logistic regression analysis was applied to analyze the data collected from South Korean firefighters (N = 5219) in 2017. According to the firefighters, participation in ET is higher among those who have someone to instruct their ET (Coefficient (Coef) = 0.057, SE = 0.017, p < 0.001) and who can do ET while on duty (Coef = 0.048, SE = 0.014, p < 0.001). The number of fire dispatches had a significant effect on participation in ET (Coef = −0.000, SE = 0.000, p < 0.01), meaning that the firefighters’ participation in ET varies with the number of fire dispatches in each region. Our main findings indicate that the number of fire dispatches is a key factor affecting ET participation among firefighters, and the other situational factors also play a role. Therefore, ET programs that firefighters can participate in between calls should be established.
Mitochondrial Activation and Reactive Oxygen-Species Overproduction during Sperm Capacitation are Independent of Glucose Stimuli

Spermatozoa capacitation is a complex process that requires specific ionic and energetic conditions to support biochemical alterations leading to motility hyperactivation. However, human sperm capacitation is still poorly understood. Herein, we studied the effects of glucose on human sperm capacitation. Healthy men seminal samples (n = 55) were submitted to a density gradient centrifugation and incubated in capacitating conditions in the absence or presence of increasing glucose concentrations (0, 5.5, 11, and 22 mM). Viability and total motility were accessed. Phosphotyrosine levels were measured. Mitochondrial activity and endogenous ROS production were evaluated. Oxidative stress-induced damage was analyzed. Culture media was collected and analyzed by 1H-NMR. Our results show that glucose is essential for human sperm capacitation and motility. Notably, we observed that mitochondrial activity increased even in the absence of glucose. This increased mitochondrial activity was followed by a ROS overproduction, although no oxidative stress-induced damage was detected. Our results show that glucose is essential for capacitation but mitochondrial activation is independent from its stimuli. ROS overproduction may take part on a finely regulated signaling pathway that modulates or even activates capacitation. Taken together, our results constitute a paradigm shift on human sperm capacitation physiology.
Chlorophyll a Fluorescence Transient and 2-Dimensional Electrophoresis Analyses Reveal Response Characteristics of Photosynthesis to Heat Stress in Malus. ‘Prairifire’

Flowering crabapples are a series of precious ornamental woody plants. However, their growth and development are inhibited in the subtropical regions due to the weak photosynthesis under high-temperature environment in the summer. Chlorophyll a fluorescence transient and 2-dimensional electrophoresis (2-DE) analyses were conducted to investigate the response characteristics of photosynthesis under simulated 38 °C heat stress in leaves of Malus. ‘Prairifire’, a spring-red leaf cultivar of flowering crabapple with strong thermal adaptability. In the present study, the net photosynthetic rate (Pn) was significantly decreased during the heat shock process, which showed a similar trend to the stomatal conductance (Gs), indicating a sensitive stomatal behavior to heat stress. Moreover, an efficient reaction center in photosystem II (PSII), and a functionally intact oxygen-evolving complex (OEC) conferred strong photosynthetic adaptability under heat stress. The higher level of transketolase (TK) under 48-h heat shock treatment was considered a protective mechanism of photosynthetic apparatus. However, heat stress inhibited the functions of light harvesting complex II (LHCII), electron transport in PSII, and the levels of key enzymes in the Calvin cycle, which were considered as the reasons causing an increase in the proportion of non-stomatal restrictions.
Relationship between Floral Characters and Floral Visitors of Selected Angiospermic Taxa from Kalakad Mundanthurai Tiger Reserve, Southern Western Ghats, India

Diurnal floral visitors of 27 woody Angiosperms wet'e observed from Kalakad Mundanthurai Tiger Reserve (KMTR), Southern Western Ghats, Tirunelveli District, between 2008 and 2010. The foraging profiles of floral visitors as well as the flower characters were analysed. It was found that although visitor profiles were sometimes consistent with classic pollination syndromes, these syndromes were unreliable predictors of floral visitors. The majority of flowering plants was unspecialized in their morphology, and consequently hosted a diverse array of visitors. Bees being the potential pollinators visited species with purple or pink flowers that are not strictly confirm to the melittophilous syndrome. Bright coloured, tubular flowers were associated with birds, with more accessible nectar. Ants were noted as nectar thieves in some plants. Altitude was a major factor in determining visitors, with flies being the most abundant visitors of m any plant species, while others received very few potential pollen vectors.
Paliperidone-Related Sudden Elevation of Plasma D-Dimer Levels: A Case Report.

To the Editors: P aliperidone, an atypical antipsychotic drug, is the major active metabolite of risperidone. It is a potent antagonist at serotonin (5-HT2A) and dopamine (D2) receptors and has an affinity for 5-HT7, dopamine D3, and α2A adrenoceptors, which link to mood, sleep, and cognition regulation. Clinical recommendation lists it as a first-line choice for long-term antipsychotic treatment in adolescents and adults because of significant improvements in symptoms and functions. The commonly reported adverse events at a recommended dosage (3–12mg daily) include akathisia, somnolence, and sedation.
Do Metabolomics and Taxonomic Barcode Markers Tell the Same Story about the Evolution of Saccharomyces sensu stricto Complex in Fermentative Environments?

Yeast taxonomy was introduced based on the idea that physiological properties would help discriminate species, thus assuming a strong link between physiology and taxonomy. However, the instability of physiological characteristics within species configured them as not ideal markers for species delimitation, shading the importance of physiology and paving the way to the DNA-based taxonomy. The hypothesis of reconnecting taxonomy with specific traits from phylogenies has been successfully explored for Bacteria and Archaea, suggesting that a similar route can be traveled for yeasts. In this framework, thirteen single copy loci were used to investigate the predictability of complex Fourier Transform InfaRed spectroscopy (FTIR) and High-performance Liquid Chromatography–Mass Spectrometry (LC-MS) profiles of the four historical species of the Saccharomyces sensu stricto group, both on resting cells and under short-term ethanol stress. Our data show a significant connection between the taxonomy and physiology of these strains. Eight markers out of the thirteen tested displayed high correlation values with LC-MS profiles of cells in resting condition, confirming the low efficacy of FTIR in the identification of strains of closely related species. Conversely, most genetic markers displayed increasing trends of correlation with FTIR profiles as the ethanol concentration increased, according to their role in the cellular response to different type of stress.
Sample size requirements for detecting treatment effect heterogeneity in cluster randomized trials

Cluster randomized trials (CRTs) refer to experiments with randomization carried out at the cluster or the group level. While numerous statistical methods have been developed for the design and analysis of CRTs, most of the existing methods focused on testing the overall treatment effect across the population characteristics, with few discussions on the differential treatment effect among subpopulations. In addition, the sample size and power requirements for detecting differential treatment effect in CRTs remain unclear, but are helpful for studies planned with such an objective. In this article, we develop a new sample size formula for detecting treatment effect heterogeneity in two‐level CRTs for continuous outcomes, continuous or binary covariates measured at cluster or individual level. We also investigate the roles of two intraclass correlation coefficients (ICCs): the adjusted ICC for the outcome of interest and the marginal ICC for the covariate of interest. We further derive a closed‐form design effect formula to facilitate the application of the proposed method, and provide extensions to accommodate multiple covariates. Extensive simulations are carried out to validate the proposed formula in finite samples. We find that the empirical power agrees well with the prediction across a range of parameter constellations, when data are analyzed by a linear mixed effects model with a treatment‐by‐covariate interaction. Finally, we use data from the HF‐ACTION study to illustrate the proposed sample size procedure for detecting heterogeneous treatment effects.
Preliminary Study of Australian Pinot Noir Wines by Colour and Volatile Analyses, and the Pivot© Profile Method Using Wine Professionals

The aim of this preliminary study was to identify potential colour components, volatile and sensory attributes that could discriminate Pinot noir wines from five Australian winegrowing regions (Adelaide Hills, Yarra Valley, Mornington Peninsula, Northern and Southern Tasmania). The sensory analysis consisted of the Pivot© Profile method that was performed by wine professionals. A headspace solid-phase microextraction-gas chromatography-mass spectrometry method was used to quantify multiple volatile compounds, while the Modified Somers method was used for colour characterisation. Analysis of data suggested ethyl decanoate, ethyl 2-methylpropanoate, ethyl 2-methylbutanoate, in addition to decanoic acid as important contributors to the discrimination between regions. Similarly, wine hue, chemical age indices, total anthocyanin, and (%) non-bleachable pigment also discriminated wines between regions. The sensory analysis showed that wines from Mornington Peninsula were associated with the ‘red fruits’ aroma, ‘acidic’, and ‘astringency’ palate descriptors, while those from Adelaide Hills were associated with the ‘brown’ colour attribute. This study indicates regionality is a strong driver of aroma typicity of wine.
Espagnolopsis and Espagnolina, Two New Genera of Eumastacid Grass- hoppers (Orthoptera: Eumastacidae: Episactinae) from Hispaniola

The new genera Espagnolopsis and Espagnolina are erected for 3 new species of Eumastacid grasshoppers from south and central Dominican Republic, Hispaniola. These grasshoppers inhabit three different high mountain areas (near and over 1,000 m) of the Cordillera Central. Espagnolina is brachypterous, while Espagnolopsis is macropterous. Most distinctive of both genera are the sexual ornamentations in the form of elevated and inwardly curving spines (1 pair in Espagnolina, 2 pairs in Espagnolopsis) projecting on the dorsal surface of the last one or two abdominal tergites of the males. These structures are homologous to those seen in Espagnola Rehn & Rehn (1939), horizontally attached on the last tergite of the abdominal dorsum. As evidenced by their internal
Profile and Areal Surface Parameters for Fatigue Fracture Characterisation

Post-mortem characterisation is a pivotal tool to trace back to the origin of structural failures in modern engineering analyses. This work compared both the crack propagation and rupture roughness profiles based on areal parameters for total fracture area. Notched and smooth samples made of weather-resistant structural steel (10HNAP), popular S355J2 structural steel and aluminium alloy AW-2017A under bending, torsion and combined bending–torsion were investigated. After the fatigue tests, fatigue fractures were measured with an optical profilometer, and the relevant surface parameters were critically compared. The results showed a great impact of the loading scenario on both the local profiles and total fracture areas. Both approaches (local and total fracture zones) for specimens with different geometries were investigated. For all specimens, measured texture parameters decreased in the following order: total area, rupture area and propagation area.
Vascular Shutdown by Photodynamic Therapy Using Talaporfin Sodium

Photodynamic therapy (PDT) is an attractive cancer treatment modality. Talaporfin sodium, a second-generation photosensitizer, results in lower systemic toxicity and relatively better selective tumor destruction than first-generation photosensitizers. However, the mechanism through which PDT induces vascular shutdown is unclear. In this study, the in vitro effects of talaporfin sodium-based PDT on human umbilical vein endothelial cells (HUVECs) were determined through cell viability and endothelial tube formation assays, and evaluation of the tubulin and F-actin dynamics and myosin light chain (MLC) phosphorylation. Additionally, the effects on tumor blood flow and tumor vessel destruction were assessed in vivo. In the HUVECs, talaporfin sodium-based PDT induced endothelial tube destruction and microtubule depolymerization, triggering the formation of F-actin stress fibers and a significant increase in MLC phosphorylation. However, pretreatment with the Rho-associated protein kinase (ROCK) inhibitor, Y27632, completely prevented PDT-induced stress fiber formation and MLC phosphorylation. The in vivo analysis and pathological examination revealed that the PDT had significantly decreased the tumor blood flow and the active area of the tumor vessel. We concluded that talaporfin sodium-based PDT induces the shutdown of existing tumor vessels via the RhoA/ROCK pathway by activating the Rho-GTP pathway and decreasing the tumor blood flow.
Favorites and leftovers on the menu of scavenging seabirds: modelling spatiotemporal variation in discard consumption

Fishery discards subsidise the food supply of a large community of scavenging seabirds, thus substantially influencing seabird ecology. Seabird preference for certain types of discards determines the number and composition of discards available for non-avian marine scavengers. To quantify both portions of discards temporally as well as spatially, we have used a modelling framework that integrates the spatial and temporal variation in seabird distribution, seabird attraction to fishing vessels, and discard distribution. The framework was applied to a case study in the Bay of Biscay, where a wide variation in discard consumption was observed across seabird foraging guilds, discard types, periods, and locations. Seabirds removed about one-quarter of the Bay of Biscay discards. The remaining sinking discards have limited potential to subsidize scavenging benthic communities on a large scale, but they may contribute substantially to scavenger diets on a local scale. Changes in food subsidies caused by discard .
Development of a Dual Fluorescent Microsphere Immunological Assay for Detection of Pseudorabies Virus gE and gB IgG Antibodies

Pseudorabies, also known as Aujezsky’s disease, is an acute viral infection caused by pseudorabies virus (PRV). Swine are one of the natural hosts of pseudorabies and the disease causes huge economic losses in the pig industry. The establishment of a differential diagnosis technique that can distinguish between wild-type infection and vaccinated responses and monitor vaccine-induced immunoglobulin G(IgG) is crucial for the eventual eradication of pseudorabies. The aim of this study was to develop a rapid dual detection method for PRV gE and gB protein IgG antibodies with high specificity and sensitivity. PRV gE codons at amino acid residues (aa) 52–238 and gB codons at aa 539–741 were expressed to obtain recombinant PRV gE and gB proteins via a pMAL-c5x vector. After purification with Qiagen Ni–nitrilotriacetic acid (NTA) agarose affinity chromatography, the two proteins were analyzed via SDS-PAGE and immunoblotting assays. Two single fluorescent-microsphere immunoassays (FMIAs) were established by coupling two recombinant proteins (gE and gB) to magnetic microbeads, and an effective dual FMIA was developed by integrating the two single assays. Optimal serum dilution for each assay, correlation with other common swine virus-positive sera, and comparison with ELISA for two PRV antigens were tested for validation. Compared with ELISA, the specificity and sensitivity were 99.26% and 92.3% for gE IgG antibody detection, and 95.74% and 96.3% for the gB IgG antibody detection via dual FMIA. We provide a new method for monitoring PRV protective antibodies in vaccinated pigs and differentiating wild-type PRV infection from vaccinated responses simultaneously.