Miracle-dz/UniFAR-FTUs huggingface dataset:
Artralji Yakinmali Multiple Sklerosis Hastalarinda Serum Human Parvovirus B19 Seropozitifliği

Objectives: The aim of this study is to investigate human parvovirus B19 (HPV B19) seropositivity in the multiple sclerosis (MS) patients with widespread arthralgia complaint. Material & methods: The study group consisted of 23 patients with relapsing-remitting MS (RR-MS), not receiving interferon treatment for prophylactic purpose, having an Extended Disability Status Score (EDSS) less than 3 and having no local or systemically diseases which may lead to arthralgia. The control group consisted of 21 cases matched according to age and sex. The levels of anti-HPV IgG and IgM were examined in sera of patients and control groups. Results: The levels of anti-HPV IgG and IgM in sera were not differing significantly between the patients with MS versus control group. Conclusion: Although anti-HPV B19 IgG and IgM antibody levels were higher in MS patients, this difference between MS and control groups was not statistically significant. ©2004, Firat Universitesi, Tip Fakultesi
Denervação Renal com Cateter de Ablação por Radiofrequência de Ponta Irrigada em Hipertensos Resistentes

Background: The 3-year results of the Symplicity HTN-1 trial have shown the superiority of renal sympathetic denervation over drug treatment in patients with resistant hypertension. However, the efficacy of renal sympathetic denervation was not confirmed by Symplicity HTN-3, the first sham-controlled study. Our objective was to report the safety and efficacy of renal sympathetic denervation using the irrigated radiofrequency ablation catheter in patients with resistant hypertension. Methods: Twenty-one patients were submitted to the procedure since July 2012, nine of them had a follow-up ≥ 12 months and were included in this analysis. The primary endpoint was safety, evaluated by periprocedural adverse events, renal function and renal vascular abnormalities at 6 months. Secondary endpoints included changes in blood pressure obtained in office and in the number of anti-hypertensive drugs at 12 months. Results: Mean age was 48.8 ± 11.7 years. In the first case, there was a renal artery dissection caused by the vascular sheath. There were no cases of thrombosis, renal infarction or death. Serum creatinine levels did not increase during the follow-up period. At 6 months, one case of significant renal stenosis without clinical impact was diagnosed. The average reduction in office blood pressure was 41.1 ± 33.2/18.6 ± 15.2 mmHg (p = 0.04 for systolic blood pressure and p = 0.08 for diastolic blood pressure) and there was a mean reduction of 2.0 ± 2.3 in the number of anti-hypertensive drugs at 12 months (p = 0.03). Conclusions: Renal sympathetic denervation using the irrigated radiofrequency ablation catheter proved to be feasible, safe and effective.
Evidence-based bedside swallowing assessment by nurses for the patients with stroke

Background and Purpose Stroke is the loss of brain’s function caused by hypoxia of brain cells depending on the severity and the location of the stroke. In Hong Kong, strokes are the 4th leading cause of death and morbidity in the year of 2010. Dysphagia is a common morbidity related to stroke. Approximately, 50% of stroke patients with dysphagia are suffered with aspiration and aspiration pneumonia which may lead to increased length of stay in hospitals, mortality rate and medical costs. An early nursing dysphagic screening and assessment protocol can help in early detect of dysphagia and therefore help to reduce incidence of aspiration and pneumonia. In order to understand the effectiveness of the nursing dysphagic screening and assessment protocol for the acute stroke patients, a number of studies have been reviewed to gather evidences for the translational research. A bedside nursing swallowing screening and assessment for patients with stroke is developed by incorporating findings from the literature review. Review Question In comparison to the routine care, is the nursing dysphagia assessment intended for the acute stroke patients more effective in reducing (1) the waiting time for having swallow assessment and the (2) the incidence of aspiration and pneumonia? Methods A systematic review of literatures from Ovid Medline (from 1946 to 2012), Pubmed (all dates), CINAHL Plus (from 1971 to 2012) and China Journal Net (from 1912 to 2012) was conducted. Five studies of bedside swallow screening and assessment that can be performed by nurses were selected and critically appraised using the recognized assessment criteria. Results The key components identified from the reviewed studies including swallowing assessment should be performed by trained nurses and acute stroke patients should be alert and able and can keep the sit up position during the swallowing assessment. Moreover, water swallowing test must be included as a part of the swallow assessment and assessment should best be performed in daily basic. Patients should be keeping nil of mouth when they failed the screening and referred for further assessment and management. Implementation potential in terms of transferability, feasibility and the cost benefit ratio of the proposed innovation were assessed. A communication plan was developed for the integration of the proposed innovation into the clinical setting. Outcome measures such as positive predictive value of detecting dysphagia, mean waiting time of waiting the initial swallow screening, occurrence of pneumonia, staff knowledge and compliance were identified to evaluate the effectiveness of the proposed innovation and guideline. Conclusion The findings of this systematic review showed that the nursing dysphagic swallow screening and assessment is effective in detecting the dysphagia of the acute stroke patients. Further development of the proposed innovation will be conducted in the clinical setting in order to satisfy the needs of the acute stroke patients.
Diagnóstico de Helicobacter pylori mediante la reacción en cadena de la polimerasa

: The Polymerase Chain Reaction (PCR) is a biotechnological useful tool for the diagnosis of bacteria or viruses with high in vitro growth requirements. Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the upper part of the gastrointestinal tract and its diagnosis is very important since it is associated with chronic gastritis, peptic ulcer, and gastric carcinomas. Because of the difficult growth requirements of the H. pylori, the PCR is being used for its diagnosis in samples of gastric biopsy, gastric juices, feces, saliva and subgingival plaque using specific H. pylori DNA fragments. This paper is a literature review that outlines the use of PCR in the diagnosis of H. pylori, the benefits and future applications of this technique in this area.
Ventilation à domicile chez les patients atteints d'une maladie neuromusculaire : étude des patients suivis pendant 10 ans dans les cantons de Genève et Vaud

Les patients atteints de maladies neuromusculaires impliquant les muscles respiratoires decedent le plus souvent d'une insuffisance respiratoire aigue precipitee par une infection, faisant tres souvent suite a une insuffisance respiratoire chronique le plus frequemment symptomatique. La ventilation mecanique a domicile est une technique qui a connu un essor important au cours des annees 80 et qui permet d'augmenter de maniere importante la survie de la plupart de ces patients, de soulager les symptomes lies a l'insuffisance respiratoire et d'ameliorer ainsi significativement la qualite de vie. Ce travail rapporte l'experience de 10 ans de ventilation a domicile chez des patients atteints de maladies neuromusculaires dans les cantons de Geneve et Vaud. Il decrit les caracteristiques fonctionnelles des patients au moment de l'introduction de la ventilation, et leur devenir. Il aborde les buts et les implications ethiques de la ventilation dans ce groupe de malades.
Alterung und Immunität

Zusammenfassung Das Altern ist mit einer Zunahme der Häufigkeit degenerativer Erkrankungen ebenso assoziiert wie mit dem vermehrten Auftreten von Autoimmun- und Krebserkrankungen. Die Untersuchungen der vergangenen Jahre unterstützen eindeutig die These eines Immunsystems, das einem physiologischen Alterungsprozess unterliegt. Bezeichnend für diese Immunseneszenz sind zudem Defekte in der zellulären Immunität mit resultierender vermehrter Infektanfälligkeit, dem Verlust zuvor erworbener spezifischer Immunität sowie einer verminderten Effektivität von Impfungen. Hier liegt jedoch auch die Krux: Die Unterscheidung zwischen der physiologischen Alterung einerseits und altersassoziierten Erkrankungen andererseits ist außerordentlich schwierig. Dieser Artikel wird versuchen, den Prozess der Immunseneszenz näher zu charakterisieren und auf die Veränderungen des Immunsystems einzugehen, die möglicherweise eine Rolle bei der Entwicklung von Autoimmunerkrankungen spielen. Es werden auch vielversprechende Ausblicke auf mögliche therapeutische Optionen zur Korrektur dieser Veränderungen gegeben.
Long term isokinetic evaluation of the knee flexor muscles after ACL reconstruction, using gracilis and semitendinosus tendon grafts

Long term isokinetic evaluation of the knee flexor muscles after ACL reconstruction, using gracilis and semitendinosus tendon grafts J.-M. Parisauxa, P. Boileaub, C. Desnuellea and M. Bergb Department of Rehabilitation, Nice University Hospital, Hopital de l’Archet, BP 3079, 06202 Nice, France Department of Orthopaedic Surgery and Sports Traumatology, Nice University Hospital, H opital de l’Archet, BP 3079, 06202 Nice, France
Evaluation of the National Program of Oral Health Promotion (NPOHP) at schools in Castelo Branco, Portugal

Aim: to evaluate the impact of the National Program of Oral Health Promotion (NPOHP) in children from Castelo Branco (Portugal) through the evaluation of DMFT/dmft indexes and the association between these indicators and different socioeconomic variables. Methodology: One hundred and thirty-five children aging 6-7 and 169 aging 11-12 years from public schools (urban and rural region) of Castelo Branco (Portugal) were randomly selected in the sample. Forty-nine percent of the children aging 6-7 and 55.0% aging 11-12 from the sample participated in the program. A semi-structured questionnaire was applied to get information about socioeconomic, behavior and knowledge factors regarding to oral health. Univariate and multivariate analyses were applied. Results: the dependent variable was “dmft+DMFT”. Statistically significant differences were verified for both ages to the dmft+DMFT indexes means between the group that was assisted by the program and that one unassisted. Children assisted by NPOHP showed lower caries prevalence. Two independent variables (study group and father’s occupation) were statistically associated to caries experience (children aging 6-7). For children aging 11-12, caries experience was statistically associated to the study group, dwelling and father’s occupation. In the multivariate analysis, the variable “study group” remained in the model for both age groups. Conclusion: the children who were included in the NPOHP program showed lower dental caries prevalence; therefore, it is crucial that children unassisted by the NPOHP program join it.
Perinatal risk in Third World cities.

A survey was conducted in the city of Pelotas in southern Brazil to study the social biological and health care utilization characteristics of mothers and the perinatal performance of their babies how these factors vary between different social classes and whether the at-risk concept is used by doctors to assist these different social groups. During 1982 7392 hospital births were studied by interviewing the mothers. A 15% random sample of the babies was visited at home after the 1st week of life. The death certificates of babies born during the year were checked and linked to the information from the perinatal questionnaires. The perinatal mortality rate for singletons was 31.9/1000. There were striking variations in the perinatal mortality rate and in the incidence of low birth weight with family income. The perinatal mortality rate was 3 times higher for babies in the poorest families than for those belonging to the wealthiest families. Birth weight was the single most important variable influencing perinatal mortality. Women at greatest need of health care were significantly less likely to use the available facilities than those with a low risk score. Doctors gave a disproportionately high amount of attention to low-risk women. A significantly higher proportion of Caesarean sections were performed among low-risk mothers than among high-risk mothers. Financial reasons seem to have markedly influenced the decision to perform Caesarean sections. The results clearly show that the health sector rather than helping to lessen the social inequalities on perinatal health actually magnifies them. Political attitudes that give higher priority to the poor should be adopted. Unless the present poorly controlled free market doctor-oriented system is not changed improvements in perinatal health care are unlikely.
Antimicrobial and Antioxidant Activities of Tribal Medicine formulation (TMF) accomplished for Wound related remedies in Biligirirangana Hill area of Chamarajanagara district, Karnataka (India)

In the exploration, association of five important less known ethno-medicinal plants (EMP) which are practiced by Tribal Medicine Men (TMM) at Biligirirangana Hill area of Chamarajanagara district, Karnataka, India were identified. The plant drugs, Andrographis serphyllifolia, Discorea hispida , Glycosmis mauritiana, Nothapodytes nimmoniana and Rauvolfia densiflora were collected during interaction and the data on TMF drug such as, part used, mode of drug preparation, dosage and duration of the treatments essentially for wound therapeutics was analytically described. The contents and amount of EMP present in the formulations were validated scientifically to ascertain the findings of pharmacognostic parameters. Further, studies on biological activities in the vein of Antimicrobial and Antioxidant activities were attempted. The antimicrobial activity was tested against standard strains such as Escherichia coli , Bacillus subtilis , Staphylococcus aureus, Kliebsiella pneumonia and Pseudomonas aerugenosa using disc diffusion method. All the extracts have shown significant activity against tested microbes with the inhibition zones ranged 7-14mm to 15-20mm. Among various solvent extracts studied petroleum ether extract showed a highest antibacterial activity followed by ethanol, aqueous extracts of EMP and TMF. The antioxidant activity has been evaluated by DPPH radical scavenging and ABTS methods, respectively. The ethno-medicinal plants showed potent inhibition of DPPH free radicals scavenging activity, D. hispida , G. mauritiana, A. serphyllifolia are being the most potent compared to other R. densiflora and N. nimmoniana . All the EMP drugs registered significantly higher in phenolic content, individually (107.67mg GAE/g) than that of TMF (102.45 mg GAE/g). Similarly, antioxidant potential was found to be noteworthy as determined by DPPH (12.24 EC 50 g/ml) radical scavenging activity which was registered in the EMF individually. A superior ABTS radical scavenging (ranging between12.06-15.40 EC 50 g/ml), Frap assay (ranging between 8.25-21.26mol Fe 2+ /mg) and significantly higher total reduction capacity (1.28%) were realized in ethanolic extract of TMF.
Pulmonary Cryptococcosis: Clinical Forms and Treatment

Cryptococcus neoformans was cultured from the sputum or lungs of 80 patients. Twenty-eight of the patients were classified as having definite or probable pulmonary disease due to C. neoformans, and 40 patients were thought to be colonized by the organism without tissue invasion. Of the 28 definite and probable cases, 23 treated patients and 4 untreated patients did well and the remaining patient was terminally ill when hospitalized. Review of the accumulated experience with cryptococcosis localized to the lungs indicates that the majority of cases resolve without treatment and that the risk of development of meningitis as a postoperative complication is low.
Effects of cage height and stocking density on the frequency of comfort behaviours performed by laying hens housed in furnished cages

Spatial restriction and low cage height can reduce the rate at which comfort activities, such as wing flaps, stretching, body shakes and tail wags, are carried out by laying hens in conventional wire cages. In this study we investigated the performance of these activities in laying hens housed in furnished cages with perches and nest boxes, similar to those required in EU legislation from 2012. We compared the behaviour of groups of eight hens at a stocking density of 762 cm2 per bird with that of pairs of hens housed at a lower stocking density of 3048 cm2 per bird at two minimum cage heights of 38 cm and 45 cm. The rates of wing/leg stretches (0.80 stretches per hen per hour), tail wagging (0.76), body shaking (0.48), wing raising (0.19) and feather raising (0.05) were low, whilst full wing flaps were not observed during the study. Hourly rates of performance of wing/leg stretches (0.45 vs 1.06) and tail wags (0.34 vs 1.25) were significantly lower in eight-bird cages than in two-bird cages. We conclude that reducing the number of hens in furnished cages increases opportunities to perform certain comfort activities, but that, even at low stocking densities, comfort activities are rarely observed.
Early changes during acute pancreatitis

Studies exploring issues related to the pathogenesis and pathophysiology of acute pancreatitis using clinically derived material are not possible because of the complex and variable nature of pancreatitis as well as the inaccessibility of the human pancreas to sampling during the early stages of the disease. As an alternative, experimentalists have employed animal models of acute pancreatitis to explore these issues. Several dissimilar models are available for such studies when rats are to be used but the secretagogue (i.e. caerulein) induced model has been the only model extensively employed in studies using mice. We now describe and characterize a mouse model of biliary necrotizing pancreatitis which may be more clinically relevant than the caerulein-induced model. It is elicited by retrogradely infusing a saline solution of the bile salt Na-taurocholate into the pancreatic duct. We show that this model is characterized by time, volume, and Na-taurocholate concentration-dependent pancreatic inflammation and necrosis which are maximal within 24 hrs of Nataurocholate infusion. The earliest light microscopic changes involve acinar cells. This application of the well characterized and clinically relevant rat model of biliary pancreatitis to mice will facilitate future studies employing genetically modified mouse strains to examine mechanistic issues related to pancreatitis.
Assessment of drunk patients

the clinic. Needless to say, this attitude had a negative effect on the patients who felt despised for taking an overdose. Another difficulty I faced was inappro priate referrals by the psychiatric trainees. The clinic was overwhelmed by referrals of drinking problems, marital difficulties and social and housing problems. This problem was solved by allocating two induction sessions for the newcomers to psychiatry to explain the function of the clinic.
Detektion von Varianten und Polymorphismen im Nicht-Strukturprotein 5A des Hepatitis C Virusgenoms, die mit einer gesteigerten Resistenz oder Sensitivität des Virus gegenüber einer antiviralen Therapie mit Peg Inerferon alfa-2a und Ribavirin assoziiert sind

Title: Virologic response to Peginterferon alfa and ribavirin in patients with chronic hepatitis C is associated with local accumulation of sequence variations in NS5A Author(s): von Wagner M, Herrmann E, Sarrazin C, Kau A, Fernandez B, Kronenberger B, Pawlotsky JM, Neumann A, Ferrari C, Schalm S, Zeuzem S Source: HEPATOLOGY 42 (4): 564A-565A Suppl. 1, OCT 2005 Abstract-Title: Prediction of virologic response in hcv genotype 1A-infected patients according to amino acid pattern in NS5A using statistical learning algorithms for classification Author(s): von Wagner M, Welsch C, Herrmann E, Sarrazin C, Kau A, Welker M, Fernandez B, Merkwirth C, Pawlotsky JM, Neumann A, Ferrari C, Schalm S, Zeuzem S Source: JOURNAL OF HEPATOLOGY 46: S247-S248 654 Suppl. 1, 2007Title: Prediction of virologic response in hcv genotype 1A-infected patients according to amino acid pattern in NS5A using statistical learning algorithms for classification Author(s): von Wagner M, Welsch C, Herrmann E, Sarrazin C, Kau A, Welker M, Fernandez B, Merkwirth C, Pawlotsky JM, Neumann A, Ferrari C, Schalm S, Zeuzem S Source: JOURNAL OF HEPATOLOGY 46: S247-S248 654 Suppl. 1, 2007
Review of Radiologic Physics

Introduction * I. What Is Radiological Physics? * II. Why Study Radiological Physics? * III. Review Book Structure * IV. Radiology Residents and the ABR Exam * V. Radiology Technologists and the ARRT Exam 1. X-Ray Production * I. Basic Physics * II. Electromagnetic Radiation * III. X-Ray Generators * IV. Making X-Rays * V. X-Ray Tubes * VI. X-Ray Tube Performance * VII. Questions * Answers to Questions 2. X-RAY INTERACTIONS * I. Matter * II. X-Rays and Matter * III. Attenuation of Radiation * IV. X-Ray Filtration Effects * V. Scatter Removal * VI. Measuring Radiation * VII. Questions * Answers to Questions 3. Projection Radiography I * I. Film * II. Intensifying Screens * III. Digital Basics * IV. Digital Detectors * V. Digital Radiography * VI. Digital Image Data * VII. Questions * Answers to Questions 4. Projection Radiography II * I. Mammography Imaging Chain * II. Clinical Mammography * III. MQSA * IV. Image Intensifiers * V. Television * VI. II/TV Imaging * VII. Questions * Answers to Questions 5. Computed Tomography * I. Hardware * II. Images * III. Scanner Operation * IV. Dosimetry * V. Miscellaneous * VI. Questions * Answers to Questions 6. Image Quality * I. Contrast * II. Resolution * III. Imaging System Resolution * IV. Noise * V. Measuring Performance * VI. Questions * Answers to Questions 7. Radiobiology/Patient Dosimetry * I. Basics * II. High Dose Effects * III. Carcinogenesis * IV. Hereditary and Teratogenic Effects * V. Patient Dosimetry * VI. Effective Dose * VII. Questions * Answers to Questions 8 Radiation Protection * I. Measuring Radiation * II. Dose Limits * III. Protecting Workers * IV. Patient Doses * V. Protecting Patients * VI. Population Doses * VII. Questions * Answers to Questions 9 Nuclear Medicine * I. Radionuclides * II. Radiopharmaceuticals * III. Planar Imaging * IV. Tomography * V. Quality Control * VI. Image Quality * VII. Radiation Doses * VIII. Questions * Answers to Questions 10 Ultrasound * I. Properties * II. Interactions * III. Transducers * IV. Imaging * V. Doppler * VI. Imaging Performance * VII. Questions * Answers to Questions 11. Magnetic Resonance * I. Physics * II. Relaxation * III. Instrumentation * IV. Imaging * V. Imaging Performance * VI. Contrast Agents * VII. Advanced Techniques * VIII. Questions * Answers to Questions Practice Examination Questions Answers to the Practice Examination Glossary Bibliography Appendices Index