Miracle-dz/UniFAR-FTUs huggingface dataset:
Study on player experience in the game world

The aim of this study is to investigate impacts from a game on players through measuring and comparing player immersion to explore game design. In terms of an instrument of player immersion in the computer game narrative and factor scores from exploratory factor analysis of a survey, this study measures and compares player immersion impacted from 5 games. The first three games are Final fantasy, Sangokushi 11 and Sword of Xuanyuan 3. And through comparing 7 dimension involved in the player immersion from the 5 games, this study proposes advices on some dimensions.
The A‐ and B‐type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2‐M transition.

We show that the sequence of Drosophila cyclin B has greater identity with B‐type cyclins from other animal phyla than with Drosophila cyclin A, suggesting that the two cyclins have distinct roles that have been maintained in evolution. Cyclin A is not detectable in unfertilized eggs and is present at low levels prior to cellularization of the syncytial embryo. In contrast, the levels of cyclin B remain uniformly high throughout these developmental stages. In cells within cellularized embryos and the larval brain, cyclin A accumulates to peak levels in prophase and is degraded throughout the period in which chromosomes are becoming aligned on the metaphase plate. The degradation of cyclin B, on the other hand, does not occur until the metaphase‐anaphase transition. In cells arrested at c‐metaphase by treating with microtubule destabilizing drugs to prevent spindle formation, cyclin A has been degraded in the arrested cells, whereas cyclin B is maintained at high levels. These observations suggest that cyclin A has a role in the G2‐M transition that is independent of spindle formation, and that entry into anaphase is a key requirement for the degradation of cyclin B.
Beneficial Effects of Torasemide on Systolic Wall Stress and Sympathetic Nervous Activity in Asymptomatic or Mildly Symptomatic Patients With Heart Failure: Comparison With Azosemide

Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated with lower mortality in patients with chronic heart failure (CHF). We evaluated the effects of torasemide, in comparison with azosemide, in patients with CHF. Patients received oral diuretic therapy with torasemide (8 mg/d, n = 15) or azosemide (60 mg/d, n = 15) for 3 months. Torasemide and azosemide were then switched, and the patients were treated for another 3 months. Torasemide treatment induced significant decreases in left ventricular (LV) systolic wall stress (from 259 ± 95 to 232 ± 80 kdyn/cm2) and the plasma level of aldosterone (from 133 ± 61 to 95 ± 50 pg/mL) and was not associated with a change in the plasma level of norepinephrine. In contrast, the plasma level of norepinephrine was significantly increased (from 370 ± 170 to 481 ± 247 pg/mL), whereas LV systolic wall stress was unchanged after azosemide treatment. This study indicates that torasemide treatment reduced LV systolic wall stress without activation of the sympathetic nervous system in patients with CHF. The anti-aldosteronergic properties of torasemide may contribute to its favorable effects.
Intellectual Capital as a Factor of Fundamental Analysis

Nowadays, society is at the new stage of the economic development when the quality and rate of continuous education of people and organizations play a major role. Those companies have the bigger financial success, which hold not only traditional factors of production but also technologies, and which develop actively the intellectual capital. So we can suppose that the increasing role of intellectual capital in modern society leads to the increasing internal company’s value when it comes to generating good cash flow and keeping up sustainable growth is not enough to have visible assets. So, the investor on the stock market faces the problem when he or she makes investment decisions because of the reviewed gap between the market value and the internal value of company. The investment decision making process is based on data from balance sheets as a traditional approach of fundamental analysis which does not consider intellectual capital. Therefore, the fundamental analysis does not respond to the modern demands showing more clearly the results of the companies’ actions for making investment decisions. As a result, we need to find or propose new ways for fundamental analysis to keep up in reality. The research objective is to determine the role and the endowment of intellectual capital in creating the internal value of a company as a factor of the fundamental analysis, and also elaborate recommendations for the investment decision making process based on updated methodology of fundamental analysis. In this research we attempt to modify a traditional approach of the fundamental analysis to increase its meaningfulness by adding a new factor – intellectual capital – and to provide recommendations for investors. The modified methodology was approved for analysis by the Company VimpelCom (telecommunications).
Engagement-sensitive interactive neuromuscular electrical therapy system for post-stroke balance rehabilitation - a concept study

Stroke is caused when an artery carrying blood from heart to an area in the brain bursts or a clot obstructs the blood flow thereby preventing delivery of oxygen and nutrients. About half of the stroke survivors are left with some degree of disability. Neuroplasticity is involved in post-stroke functional disturbances, but also in rehabilitation. Beneficial neuroplastic changes may be facilitated with neuromuscular electrical stimulation (NMES) where active cortical participation in rehabilitation procedures may be facilitated by driving NMES with electromyogram (EMG), electrooculogram (EOG), and electroencephalogram (EEG) derived biopotentials, that represent simultaneous volitional effort and task engagement. During the visuomotor standing balance task, we propose that gaze-interaction (e.g., fixation duration, pupil diameter, blink rate) with the visual stimuli can be a measure of task engagement which can be used to adapt task difficulty to facilitate post-stroke residual visuomotor function. Here, the elapsed time between the last visual fixation to the target and the initiation of the motor response, known as the quiet eye (QE) period, has emerged as a characteristic of higher levels of performance. In this article, we discuss this novel interactive therapy paradigm consisting of a low-cost static posturography system combined with engagement-sensitive volitionally driven NMES for post-stroke balance rehabilitation.
Vaccine for contraception targeting sperm

Summary: Development of a vaccine(s) based on sperm antigens represents a promising approach to contraception. The utility of a sperm antigen ill immunocontraception is contingent upon its tissue specificity, involvement in fertility and on raising high antibody deer, especially locally in the genital tract, that is capable of inducing reversible infertility. Several sperm antigens, such as lactate dehydrogenase C4, PH‐20, sperm protein (SP)‐10, fertilization antigen (FA)‐1, FA‐ 2, cleavage signal (CS)‐1, NZ‐1, and NZ‐2 have been proposed as potential candidates for the vaccine development. Spermzona pellucida (ZP) binding is a pivotal tissue‐ and mostly species‐specific event in the fertilization process, and the molecules involved in this site constitute che most exciting candidates for immuno‐contraception. FA‐1 is a sperm‐specific glycoprotein having receptor activity for ZR recognition and binding. Complementary DNA encoding for FA‐1 antigen has been cloned and sequenced. Active immunization of animals with recombinant FA‐1 antigen causes a long‐lasting reversible inhibition in fertility by raising a sperm‐specific immune response. This antigen is also involved in human immunoinfertility. The exciting findings from the recent trial in immunoinfertile couples indicate that the FA‐1 antigen may have clinical application in the treatment of male infertility. A vaccine having most appropriate tissue‐specific and effective recombinant and/or synthetic epitopes of various sperm antigens, such as the FA‐1 antigen, in a single formulation may provide a highly immunogenic and efficacious antisperm vaccine for contraception. The advances made during che last 5 years suggest that it may be a realistic proposition.
Accounting for technology, trade and final consumption in employment: an Input-Output decomposition

What are the driving forces of changes in employment in France over the last thirty years and how can we explain skill-biased changes in employment? Based on Input-Output analysis we provide a decomposition of changes in employment between the contributions of three channels : technology, trade and final consumption. Our goal is to assess these contributions to employment changes by skill level over the period 1982-2010. Our analysis builds on textbook methodologies of structural decomposition, but innovative data: INSEEs Input-Output tables both in current and previous year prices, based on the new ESA2010 concepts. Our main findings are that technology shows marked skill-bias, whereas trade and final consumption have limited skill-bias effects. The development of high-technology manufacturing and R&D over the last thirty years mainly contributes to this skill-biased change in employment. We find a positive contribution of trade to employment at every skill level.
Synthesis of Substituted 1,3-Diesters of Glycerol Using Wittig Chemistry

1,3-di-O-Cinnamoyl-glycerol is a natural compound isolated from a Jamaican medicinal plant commonly referred to as Ball moss (Tillandsia recurvata). The synthesis of this compound was achieved via a Wittig chemistry process. The synthetic approach started with acylation of a di-protected glycerol with cinnamoyl chloride, deprotection of the glycerol moiety, reaction of the primary alcohol with bromo acetylbromide followed by treatment with triphenyl phosphine to give the corresponding phosphonium bromide. The phosphonium bromide was then converted in situ to the Wittig reagent which is the basis for a novel route to 1,3-di-O-cinnamoyl glycerol. Four analogs were also synthesized, three of which are new and are being reported in this article for the first time. The new compounds include 3-(3,4-diemthoxy-phenyl)-acrylic acid 2-hydroxy-3-(3-ptolyl-acryloyloxy)-propyl ester (3), 2-acetoxy-5-((E)-3-(3-((E’)-3-(3,4-dimethoxyphenyl)acryloyloxy)-2-hydropropoxy)-3-oxoprop-1-enyl)benzoic acid (4) and 4-((E)-3-(3-((E)-3-(3,4-dimethoxyphenyl)acryloyloxy)-2-hydropropoxy)-3-oxoprop-1-enyl)benzoic acid (5). The compounds showed no activity in our anticancer assay.
Modeling and analysis of AC resistance of a permanent magnet machine for online estimation purposes

A simple and accurate AC resistance model is essential for online estimation of copper loss which can be utilized in several ways of controlling and monitoring. This paper presents application of Squared Field Derivative on three-phase IPM machine to model AC resistance of rectangular conductors. It focuses on Finite Element Analysis to validate analytical model. The deviations from analytical model due to saturation and field weakening at high speeds are studied in detail and the significance of these deviations on the context of operating regions is discussed. This paper also presents application of the same analytical approach to model AC resistance of overhang conductors.
Jasmonic acid changes the composition of essential oil isolated from narrow-leaved lavender propagated in in vitro cultures

Abstract The aim of the present study was to determine the effect of jasmonic acid added to the culture medium on composition of Lavandula angustifolia essential oils. The chemical composition was determined by gas chromatography coupled to mass detector (GC/MS). The experiment was conducted with the use of MS medium supplemented with increasing concentration of JA (0.2, 0.5, 1, 1.5 mg∙dm−3). It was found that the analysed essential oils varied in terms of chemical composition depending on the content of JA in the medium. All obtained essential oils were characterised by a high content of σ-cadinene (17.06–29.64%), borneol (6.66–17.47%), caryophyllene oxide (8.30–14.01%), τ-cadinol (4.87–9.16%), beta-caryophyllene (3.54–6.57%), 1.8-cineole (1.94–5.87%), β-pinene (1.48–3.05%), geranyl acetate (0.56–2.14%) and myrtenal (0.65–2.14%).
Increased Hepatic Fructose 2,6-Bisphosphate after an Oral Glucose Load Does Not Affect Gluconeogenesis*

The generally accepted metabolic concept that fructose 2,6-bisphosphate (Fru-2,6-P2) inhibits gluconeogenesis by directly inhibiting fructose 1,6-bisphosphatase is based entirely on in vitro observations. To establish whether gluconeogenesis is indeed inhibited by Fru-2,6-P2 in intact animals, a novel NMR method was developed using [U-13C]glucose and 2H2O as tracers. The method was used to estimate the sources of plasma glucose from gastric absorption of oral [U-13C]glucose, from gluconeogenesis, and from glycogen in 24-h fasted rats. Liver Fru-2,6-P2 increased ∼10-fold shortly after the glucose load, reached a maximum at 60 min, and then dropped to base-line levels by 150 min. The gastric contribution to plasma glucose reached ∼50% at 30 min after the glucose load and gradually decreased thereafter. Although the contribution of glycogen to plasma glucose was small, glucose formed from gluconeogenesis was substantial throughout the study period even when liver Fru-2,6-P2 was high. Liver glycogen repletion was also brisk throughout the study period, reaching ∼30 μmol/g at 3 h. These data demonstrate that Fru-2,6-P2 does not inhibit gluconeogenesis significantly in vivo.
A novel small molecule, Rosline, inhibits growth and induces caspase‐dependent apoptosis in human lung cancer cells A549 through a reactive oxygen species‐dependent mechanism

Chemical screening using synthetic small molecule libraries has provided a huge amount of novel active molecules. It generates lead compound for drug development and brings focus on molecules for mechanistic investigations on many otherwise intangible biological processes. In this study, using non‐small cell lung cancer cell A549 to screen against a structurally novel and diverse synthetic small molecule library of 2,400 compounds, we identified a molecule named rosline that has strong anti‐proliferation activity on A549 cells with a 50% cell growth inhibitory concentration (IC50) of 2.87 ± 0.39 µM. We showed that rosline treatment increased the number of Annexin V‐positive staining cell, as well as G2/M arrest in their cell cycle progression. Further, we have demonstrated that rosline induces a decrease of mitochondrial membrane potential (Δφm) and an increase of caspases 3/7 and 9 activities in A549 cells, although having no effect on the activity of caspase 8. Moreover, we found that rosline could induce the production of reactive oxygen species (ROS) and inhibit the phosphorylation of signaling molecule Akt in A549 cells. Alternatively, an antioxidant N‐acetyl‐L‐cysteine (NAC) significantly attenuated rosline's effects on the mitochondrial membrane potential, caspases 3/7 and 9 activities, cell viabilities and the phosphorylation of Akt. Our results demonstrated that ROS played an important role in the apoptosis of A549 cells induced by rosline.
Mucosal Immunization with Virus-Like Particles of Simian Immunodeficiency Virus Conjugated with Cholera Toxin Subunit B

ABSTRACT To enhance the efficiency of antigen uptake at mucosal surfaces, CTB was conjugated to simian immunodeficiency virus (SIV) virus-like particles (VLPs). We characterized the immune responses to the Env and Gag proteins after intranasal administration. Intranasal immunization with a mixture of VLPs and CTB as an adjuvant elicited higher levels of SIV gp160-specific immunoglobulin G (IgG) in sera and IgA in mucosae, including saliva, vaginal-wash samples, lung, and intestine, as well as a higher level of neutralization activities than immunization with VLPs alone. Conjugation of CTB to VLPs also enhanced the SIV VLP-specific antibodies in sera and in mucosae to similar levels. Interestingly, CTB-conjugated VLPs showed higher levels of cytokine (gamma interferon)-producing splenocytes and cytotoxic-T-lymphocyte activities of immune cells than VLPs plus CTB, as well as an increased level of both IgG1 and IgG2a serum antibodies, which indicates enhancement of both Th1- and Th2-type cellular immune responses. These results demonstrate that CTB can be an effective mucosal adjuvant in the context of VLPs to induce enhanced humoral, as well as cellular, immune responses.
Lead distribution and its potential risk to the environment: Lesson learned from environmental monitoring of abandon mine

There are many abandon and existing mines (tin, lead and zinc) in the mountainous areas of Thailand. Toxic elements including heavy metals such as lead (Pb), cadmium (Cd) and arsenic (As) have been released and transported from the mining sites to the adjacent landscape. In Thong Pha Phum District, Kanchanaburi Province, Thailand Pb contamination in the vicinity of the mine has occurred which could lead to potential health problems in downstream communities. To better understand current status of Pb contamination and accumulation in the surrounding environment and potential health impact, surface sediment, soil and plant samples were collected seasonally from representative monitoring sites along the aquatic track or flow regime. Potential health risk was determined using hazard quotient (HQ) as an index for local inhabitants who consume rice. Environmental monitoring illustrated that Pb concentrations in the surface sediment was as high as 869.4 mg kg−1 dry weight and varied differently among stations sampled. Lead content in agricultural soil ranged between 137.8 to 613.5 mg kg−1 dry weight and was inversely proportion to the distance from the point source. Moreover Pb was transported from the point source to down hill areas. At the highly polluted monitoring stations (S1, S2, and S3), concentrations of Pb exceeded the maximum allowable concentration for Pb in agricultural soil (300 mg kg−1) by 1.7–2 times. The Pb in soil was primarily associated with Fe/Mn oxides bound fraction (46–56%) followed by the organic bound fraction (25–30%). Lead uptake by plant varied and was species dependent. However root and tuber crops like cassava (19.92 mg Pb kg−1 dry weight) and curcumin (3.25 mg Pb kg−1 dry weight) could have removed Pb from the soil which suggest growing root crops in Pb contaminated soils should be avoided. However Cd, a co-contaminant at one of monitored stations (S4) yielded rice grain with Cd exceeding the maximum allowable concentration suggesting some potential health risk (HQ = 5.34) if people consume rice grown at this station. Overall result shows a low risk associated with Pb release into the environment.
A Long Short-Term Memory Recurrent Neural Network Framework for Network Traffic Matrix Prediction

Network Traffic Matrix (TM) prediction is defined as the problem of estimating future network traffic from the previous and achieved network traffic data. It is widely used in network planning, resource management and network security. Long Short-Term Memory (LSTM) is a specific recurrent neural network (RNN) architecture that is well-suited to learn from experience to classify, process and predict time series with time lags of unknown size. LSTMs have been shown to model temporal sequences and their long-range dependencies more accurately than conventional RNNs. In this paper, we propose a LSTM RNN framework for predicting short and long term Traffic Matrix (TM) in large networks. By validating our framework on real-world data from GEANT network, we show that our LSTM models converge quickly and give state of the art TM prediction performance for relatively small sized models.
Interleukin-4 and Transforming Growth Factor β Have Opposing Regulatory Effects on Gamma Interferon-Mediated Inhibition of Cryptosporidium parvum Reproduction

ABSTRACT It was shown previously that enterocytes activated by gamma interferon (IFN-γ) are efficient effector cells in the killing of Cryptosporidium parvum. How this function is regulated is not clearly understood, but transforming growth factor β (TGF-β) and the Th2 regulatory cytokines may play a role. Using an in vitro cell culture system, we investigated how the key regulatory cytokines interleukin-4 (IL-4), IL-10, IL-13, and TGF-β might modulate the effect of IFN-γ in inducing resistance to infection in enterocyte cell lines. The results showed that TGF-β can abolish the inhibitory effect on C. parvum development and that neither IL-13 nor IL-10 influenced the action of IFN-γ. In contrast, IL-4 cooperated with low concentrations of IFN-γ (1 and 10 U/ml) to enhance parasite killing. One mechanism that appeared to be involved in the combined activity of IFN-γ and IL-4 was intracellular Fe2+ deprivation, but induction of nitric oxide production was not involved. In one cell line, the extents and durations of phosphorylation of STAT1, a transcription factor involved in IFN-γ signaling, were similar when cells were stimulated with IFN-γ alone and with IFN-γ and IL-4γ, suggesting that the cooperative effect of the cytokines was not related to STAT1 activation. The effects of the presence of TGF-β and IL-4 on IFN-γ function did not appear to involve any alteration in the level of expression of IFN-γ receptors.
Forecasting with Real-Time Data Vintages

Thanks to Tom Stark for many discussions about real-time data issues over many years. This paper was written in part while the author was a visiting scholar at the Real-Time Data Research Center at the Federal Reserve Bank of Philadelphia. The views expressed in this paper are those of the author and do not necessarily represent the views of the Federal Reserve Bank of Philadelphia or the Federal Reserve System.
Proteome-wide Alterations in Escherichia coli Translation Rates upon Anaerobiosis

Enzyme reprofiling in bacteria during adaptation from one environmental condition to another may be regulated by both transcription and translation. However, little is known about the contribution of translational regulation. Recently, we have developed a pulse labeling method using the methionine analog azidohomoalanine to determine the relative amounts of proteins synthesized by Escherichia coli in a brief time frame upon a change in environmental conditions. Here we present an extension of our analytical strategy, which entails measuring changes in total protein levels on the same time scale as new protein synthesis. This allows identification of stable and labile proteins and demonstrates that altered levels of most newly synthesized proteins are the result of a change in translation rate rather than degradation rate. With this extended strategy, average relative translation rates for 10 min immediately after a switch from aerobiosis to anaerobiosis were determined. The majority of proteins with increased synthesis rates upon an anaerobic switch are involved in glycolysis and pathways aimed at preventing glycolysis grinding to a halt by a cellular redox imbalance. Our method can be used to compare relative translation rates with relative mRNA levels at the same time. Discrepancies between these parameters may reveal genes whose expression is regulated by translation rather than by transcription. This may help unravel molecular mechanism underlying changes in translation rates, e.g. mediated by small regulatory RNAs.