Miracle-dz/UniFAR-FTUs huggingface dataset:
OBTENCIÓN DE ACREDITACIONES INTERNACIONALES EN PROGRAMAS DE INGENIERÍA EN UNA UNIVERSIDAD ESTATAL DE MÉXICO

Las acreditaciones en programas educativos dan certeza de que los profesionales que egresan tienen una base educativa solida y son capaces de liderar en la innovacion y en tecnologias emergentes anticipandose a las necesidades de bienestar y seguridad de la gente. La demanda de ingenieros por parte de las empresas internacionales asi como la busqueda de formar ingenieros mas competitivos para Mexico y para el mundo motivo a la Facultad de Ingenieria de la Universidad Autonoma de San Luis Potosi (UASLP) a la busqueda de tener programas educativos conformes con estandares internacionales. Por lo anterior en la Facultad de ingenieria de la UASLP se planteo en el 2009 un plan para que en un lapso de 5 anos se obtuviera la acreditacion de al menos la mitad de las carreras por parte de un organismo acreditador internacional. Como resultado, se acreditaron cinco carreras hasta el ano 2017, tres de ellas con revision a termino medio.
Eating Disorders Across the Life Span

SUMMARY Eating disorders have traditionally been considered afflictions of adolescents and young women. Recent evidence, however, suggests that eating disorders often occur across the life span. Although the incidence of these disorders among mid-life and older women appears to be on the rise, it is not clear if this reflects a true increase in prevalence, better recognition among clinicians, or both. This paper presents an overview of the etiology and treatment of eating disorders, with particular emphasis on developmental factors impacting older women. Recommendations for the treatment of eating disorders among older women are offered. An emerging clinical literature suggests various lines of research that are needed to explore the development and treatment of eating disorders in older women.
A novel nano-scale non-contact temperature measurement technique for crystalline materials

A new high spatial resolution non-contact temperature measurement technique (thermal scanning electron microscopy, ThSEM) is demonstrated. It employs temperature dependent thermal diffuse scattering in electron backscatter diffraction (EBSD) in a scanning electron microscope (SEM). Unlike conventional scanning thermal microscopy, which uses contact probes, ThSEM is a non-contact method. In contrast to optical temperature mapping techniques, ThSEM does not have the spatial resolution limitation that arises from the optical wavelength and theoretically can reach a resolution of <10 nm. The hardware setup is very similar to the EBSD system in an SEM, which can make the integration of temperature mapping into an SEM relatively straightforward. Moreover, multiple signals or contrast mechanisms, such as temperature distributions, grain orientation maps, topographic images and elemental maps can be obtained from the same sample area depending on the specific SEM capability. This technique thus adds a new channel—the temperature signal—to the collection of existing SEM signals.
The contribution of the autonomic nervous system to changes of glucagon and insulin secretion during hypoglycemic stress.

During hypoglycemic stress, glucagon secretion increases and insulin secretion decreases. The traditional view is that these changes are due to the effect of low circulating glucose levels acting directly on the pancreatic islet. In contrast, a number of studies suggest that these responses are due to activation of autonomic nervous system that accompanies hypoglycemia in vivo, a view that we favor. Although central nervous system and autonomic neural control of the endocrine pancreashas been reviewed before (1–4), this review will focus specifically on the autonomic activation produced by glucopenic stress and its potential contribution to the accompanying changes of glucagon and insulin secretion. The goal of this review is not to negate the traditional view that hypoglycemia has direct actions on the islet, but rather to suggest that the autonomic contribution may have been underestimated in a whole class of experiments because of unrecognized redundancy in the autonomic input to the islet. The first section will review the supporting evidence that each of three autonomic inputs to the pancreas is activated during this stress. The three inputs are: 1) pancreatic parasympathetic nerves, 2) adrenal medullary epinephrine, and 3) pancreatic sympathetic nerves. The various techniques for measuring these autonomic inputs to the pancreas will be discussed, and the factors which influence the magnitude of the autonomic activation will be outlined. © 1989 by The Endocrine Society.
Structural Basis for Endosomal Targeting by FYVE Domains*

The FYVE domain is a conserved protein motif characterized by its ability to bind with high affinity and specificity to phosphatidylinositol 3-phosphate (PI(3)P), a phosphoinositide highly enriched in early endosomes. The PI(3)P polar head group contacts specific amino acid residues that are conserved among FYVE domains. Despite full conservation of these residues, the ability of different FYVE domains to bind to endosomes in cells is highly variable. Here we show that the endosomal localization in intact cells absolutely requires structural features intrinsic to the FYVE domain in addition to the PI(3)P binding pocket. These features are involved in FYVE domain dimerization and in interaction with the membrane bilayer. These interactions, which are determined by non-conserved residues, are likely to be essential for the temporal and spatial control of protein associations at the membrane-cytosol interface within the endocytic pathway.
The Microbiological Diagnosis Of The Peri-Implant Disease: Can It Really Have A Practical Significance?

J Dent Health Oral Disord Ther 2016, 4(5): 00127 present in the diseased periodontal sulcus: Porphyromonas gingivalis, Fusobacterium nucleatum, Tannerella forsythia, Treponema denticola and various species of prevotellaceae [313]. In addition to these findings, many studies analyzing the microflora of peri-implant crevice in fully edentulous subjects noted the almost total, or total, absence of those bacteria commonly found in the periodontal crevice, thus reinforcing the theory of the close similarity of the two environments and the bacterial reservoir role of natural teeth [14-16].
A meta-analytic review of polyunsaturated fatty acid compositions in dementia.

OBJECTIVE To determine whether the levels of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), arachidonic acid (AA), total n-3 polyunsaturated fatty acids (PUFAs), and total n-6 PUFAs were changed in patients with dementia or predementia syndrome. DATA SOURCES PubMed was searched for studies from first date available to July 2011 using the following search terms: (dementia OR cognitive impairment OR mild cognitive impairment) AND (omega-3 OR omega-6 OR polyunsaturated fatty acid OR docosahexaenoic acid OR DHA OR eicosapentaenoic acid OR EPA). The search was limited to literature in English and to human studies. The references of relevant articles and review articles were searched for citations not indexed in PubMed. STUDY SELECTION Studies were included if they measured levels of EPA, DHA, AA, total n-3 PUFAs, or total n-6 PUFAs from peripheral blood tissues in subjects with cognitive deficits (dementia or predementia syndrome) and elderly controls and were published in peer-reviewed journals. The search yielded 10 articles including 2,280 subjects. DATA EXTRACTION The study design, sample size, PUFA levels for both patients and control subjects, sampling tissue, diagnoses and diagnostic criteria for cognitive deficits, and distribution of mean age and gender of included subjects were extracted for each study. RESULTS In a random-effects model, we found that the levels of EPA (effect size [ES] = -0.47, P < .0001), DHA (ES = -0.33, P = .017), and total n-3 PUFAs (ES = -0.46, P = .001) were decreased in patients with dementia. However, the levels of EPA (ES = -0.44, P = .002), but not DHA or other PUFAs, were significantly lower in patients with predementia syndrome. CONCLUSIONS Our results support the important role of n-3 PUFAs in the pathophysiology of dementia. In addition, the analyses of predementia studies indicate that EPA might be not only a disease-state marker but also a risk factor for cognitive impairment.
Predictive factors of efficacy of periradicular corticosteroid injections for lumbar radiculopathy.

BACKGROUND AND PURPOSE Steroid periradicular infiltration is a common nonsurgical sciatic pain treatment of inconsistent efficacy. The purpose of this study was to identify factors for predicting the efficacy or failure of this procedure. METHODS Two hundred twenty-nine patients with lumbar radiculopathy were prospectively followed up at 2 weeks and 1 year after percutaneous periradicular steroid infiltration. The intensity of radicular pain was scored on the visual analog scale (VAS). Pain relief was classified as "excellent" when the pain was completely resolved or had diminished by 75% or more, "good" for a diminution of 50% to 74%, "fair" for a diminution of 25% to 49%, or "poor" for a diminution of less than 25% or an increase in pain. RESULTS The mean VAS scores were 6.5 (range, 3.1-9.5) before and 4.2 (range, 0-9.5) 2 weeks after the procedure. Pain relief was graded as excellent in 45 patients (19.7%), good in 48 patients (21%), fair in 45 patients (19.7%), and poor in 91 patients (39.7%). Cause of pain, conflict location, and pain intensity were not predictive factors of radicular pain relief, whereas the symptom duration before the procedure was highly correlated with the pain relief outcome. Patients with excellent results 2 weeks after the procedure had a mean duration of symptoms of 3.04 months (SD 3.28) versus 7.96 months (DS 9.04) in the group with poor pain relief. CONCLUSIONS Periradicular infiltration is a simple, safe, and effective nonsurgical procedure that should be performed quite early in the course of the illness to provide radicular pain relief, because corticosteroid infiltration is less beneficial for patients with more chronic radicular pain.
Unknown Quantity: Regulating Radionuclides in Tap Water

Radioactivity surrounds us; each day we are exposed to a certain amount by virtue of being alive on planet Earth. Some of this exposure comes from radioactive substances (radionuclides) that occur naturally in a wide variety of geologic and soil formations. Occasionally these naturally occurring substances become more concentrated or accessible through human activities such as mining and nuclear energy production, resulting in greater potential for exposure than their original natural occurrence would suggest. Other radionuclides are artificially created. Residents in almost all parts of the United States live on lands that contain minor to substantial concentrations of radionuclides of one type or another.1 These substances often make their way into tap water, leading to exposures by ingestion, inhalation, or dermal pathways during showering or other contact with the water. Although radionuclides are widespread, there are large gaps in our knowledge about sources of these materials, their distribution, associated health risks, and mitigation measures. However, the information we do have suggests that current drinking water standards for radionuclides established by the U.S. Environmental Protection Agency (EPA) may not adequately protect health. The EPA is set to review these standards relatively soon, and the next two years are prime time for filling in numerous information gaps and doing other legwork to make sure the review is as well informed as possible.
Emerging roles of deubiquitinases in cancer‐associated pathways

Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c‐Myc. Alternatively they can negatively regulate ubiquitin‐dependent signalling cascades such as the NF‐κB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future. © 2010 IUBMB IUBMB Life, 62(2): 140–157, 2010
Non‐viral gene transfer: Applications in developmental biology and gene therapy

Summary— The main limitation of non‐viral gene transfer methods is their relatively low efficiency in vivo. However, a number of approaches can be taken to improve their performances, whether the aim is studying gene function during development or employing these techniques for gene therapy. Three non‐viral delivery systems that we have been particularly involved in in developing are described: the cationic lipid, dioctadecylamidoglycylspermine (DOGS), the cationic polymer polyethylenimine (PEI) and free DNA. The application of each of these methods to different in vivo situations is presented: the use of DOGS for transfecting embryos and the developing mammalian nervous system; the recent application of PEI to the nervous system; and how naked DNA can be employed for transfecting different muscles and brain. The relative efficiencies are compared on the basis of luciferase reporter gene expression assessed in each tissue with the most appropriate vector system. Finally, the perspectives for constructing composite vectors combining safety and efficiency are considered briefly.
The Escherichia coli GTPase CgtAE Cofractionates with the 50S Ribosomal Subunit and Interacts with SpoT, a ppGpp Synthetase/Hydrolase

ABSTRACT CgtAE/ObgE/YhbZ is an Escherichia coli guanine nucleotide binding protein of the Obg/GTP1 subfamily whose members have been implicated in a number of cellular functions including GTP-GDP sensing, sporulation initiation, and translation. Here we describe a kinetic analysis of CgtAE with guanine nucleotides and show that its properties are similar to those of the Caulobacter crescentus homolog CgtAC. CgtAE binds both GTP and GDP with moderate affinity, shows high guanine nucleotide exchange rate constants for both nucleotides, and has a relatively low GTP hydrolysis rate. We show that CgtAE is associated predominantly with the 50S ribosomal subunit. Interestingly, CgtAE copurifies with SpoT, a ribosome-associated ppGpp hydrolase/synthetase involved in the stress response. The interaction between CgtAE and SpoT was confirmed by reciprocal coprecipitation experiments and by two-hybrid assays. These studies raise the possibility that the ribosome-associated CgtAE is involved in the SpoT-mediated stress response.
Crops : uma proposta de comutador programável de código aberto para prototipação de redes

Software Defined Network (SDN) promises a technological path to empower users with the ability to innovate in their networks. However, the diversity of network switches supporting SDN are still roadblocks for network engineers willing to develop innovative applications due to the closed and proprietary hardware implementation. This diversity leads to significant challenges in the control of SDN switches and the development of high performance SDN applications, hampering the core proposal of SDN: to enable fast innovation in real networks. The proposal of this work is to explore the limits of some commodity network hardware, such as Mikrotik RouterBoard switch, in which its proprietary firmware was replaced by the OpenWRT, a distribution based on GNU Linux, together with the Open vSwitch (OvS), a hardware-agnostic open source virtual switch, to create a new environment for experimentation in computer networking. As proof of concept, the prototype was implemented in low cost commercial switches, conducting experiments in order to analyze certain features of the OpenFlow protocol ported in these equipment, such as maximum number of entries in the flow table, the data plane performance using different sizes of network packets, comparing their results with the original implementation provided by the manufacturer and the influence of switch CPU utilization in the result. This combination of open platforms represent a natural step in the development, deployment, and evaluation of SDN applications.
The Watts–Strogatz network model developed by including degree distribution: theory and computer simulation

By using theoretical analysis and computer simulations, we develop the Watts–Strogatz network model by including degree distribution, in an attempt to improve the comparison between characteristic path lengths and clustering coefficients predicted by the original Watts–Strogatz network model and those of the real networks with the small-world property. Good agreement between the predictions of the theoretical analysis and those of the computer simulations has been shown. It is found that the developed Watts–Strogatz network model can fit the real small-world networks more satisfactorily. Some other interesting results are also reported by adjusting the parameters in a model degree-distribution function. The developed Watts–Strogatz network model is expected to help in the future analysis of various social problems as well as financial markets with the small-world property.
HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells

Human decidual CD14+ macrophages and CD56+ NK cells were isolated from material obtained after first-trimester pregnancy terminations. Each cell type expressed a specific surface receptor for histocompatibility leukocyte antigen (HLA)-G (an MHC class Ib protein that is expressed on extravillous trophoblasts), LILRB1 on CD14+ macrophages and KIR2DL4 on CD56+ NK cells. Cross-linking with anti-LILRB1 or anti-KIR2DL4 resulted in up-regulation of a small subset of mRNAs including those for IL-6, IL-8, and TNFα detected using a microarray representing 114 cytokines. Incubation with transfectants expressing the HLA-G homodimer (but not with transfectants expressing the HLA-G monomer) resulted in secretion of the same cytokine proteins from both leukocyte sets. Moreover, cytokine secretion from both leukocyte sets was blocked by both the appropriate anti-receptor mAb and by anti-HLA-G. The amount of these cytokines secreted by decidual macrophages was substantially greater than that secreted by decidual NK cells. VEGF was constitutively secreted by both cell types. LILRB1, which contains an immunoreceptor tyrosine-based switch motif, functions here as an activating receptor, although it has been known as an inhibitory receptor. KIR2DL4 also functions as an activating receptor, although it also has the potential to function as an inhibitory receptor. Secretion of proinflammatory and proangiogenic proteins supports a role for these leukocytes in important processes that are essential for successful pregnancy, but they may represent only a portion of the proteins that are secreted.
Fish as Source of n-3 Polyunsaturated Fatty Acids ( PUFAs ) , Which One is Better-Farmed or Wild ?

Consumption of fish as a source of eicosapentanoic acid (EPA) docosahexenoic acid (DHA) is recommended for preventing cardiovascular and other diseases. Since world’s fish stocks are limited, consumers are now being proposed farmed fish as an alternative. However, there is concern that is there any differences between wild-caught and farmraised fish? Is one type is better than others? The aim of this study was to review the published information on the n-3 PUFAs, n-3/n-6 and DHA/EPA ratios of farmed and wild fishes in order to estimate whether the health benefits of the farmed and wild fish is potentially the same. Further, health benefits of n-3 fatty acids, importance of n-3/n-6 ratios, DHA/EPA ratios, factors affecting n-3 PUFAs, limitations or safety of fish as source of n-3 PUFAs, prospects of aquaculture as potential sources of n-3 PUFAs and optimal intakes of n-3 PUFAs have also been discussed. In general, the lipid content of farmed fish is higher than the wild but the proportion of n-3 PUFAs and DHA/EPA ratios in majority of wild fish are higher than their counterparts although there was a mixed trend for n-3/n-6 ratios. As the fatty acid composition of fish is largely dependent on the fatty acid composition of their feed, it can be customized by adjusting dietary intakes. Since the farmed fish generally have higher total lipid levels than the wild, 100g of farmed fish muscle can provide a similar or higher amount of n-3 PUFA than 100g wild fish. Thus, if they are raised under appropriate conditions and dietary regimes, farmed fish can provide the consumers a nutritional composition that is at least as beneficial as that provided by the wild.
Identification of predicted seminal fluid proteins in Tribolium castaneum

In several insect species, seminal fluid proteins (SFPs) have been demonstrated to be key regulators of male and female fitness through their ability to alter female physiology and behaviour. Tribolium castaneum is an economically important pest species and a model system for sexual selection research, but little is known about SFPs in this insect. To create a foundation for the study of T. castaneum SFPs, we used mass spectrometry to identify putative SFPs by comparing proteins detected in the male reproductive glands with those found in the reproductive tracts of virgin and mated females. Fourteen putative SFPs, thirteen with male biased expression, were identified through this approach. We also used reverse transcription PCR (RT‐PCR) to examine expression levels across different tissue types. We found strongly male‐biased expression in 13 genes, nine of which were expressed only in male accessory gland tissue. This represents the first proteomic‐based method of identifying putative SFPs in any coleopteran species, and is the first study in this species to identify putative SFPs that are likely transferred to the female. This work could lead to functional analyses of the role of SFPs in sexual selection, sexual conflict and potential control of a pest species.
Immunocytochemical detection of the class A macrophage scavenger receptor CD204 using air-dried cytologic smears of canine histiocytic sarcoma.

BACKGROUND Cytologic diagnosis of canine histiocytic sarcoma (CHS) can be challenging because neoplastic histiocytes commonly show marked nuclear and cellular atypia and may resemble other pleomorphic malignant round cell tumors. Therefore, even on histopathologic examination, immunostaining is often necessary for a definitive diagnosis. OBJECTIVES The objective of this study was to validate an anti-human CD204 antibody for immunocytochemical staining of air-dried smears for a rapid definitive diagnosis of CHS. METHODS Cytologic specimens were obtained from 10 dogs with CHS and 45 dogs with other tumors. After the cytologic evaluation of modified Giemsa-stained smears, acetone-fixed specimens were immunostained using mouse anti-human CD204 antibodies. All immunocytochemical specimens were assessed blinded and at high-power magnification (× 40 objective) in 10 randomly selected fields per sample. Parameters evaluated were the subjective staining intensity and location, and the proportion of positive cells. RESULTS All 10 CHS samples showed intense positive staining for CD204 in ≥ 50% of the cells, whereas the 45 other tumors were negative for CD204 staining. CONCLUSIONS Immunocytochemistry of air-dried cytologic smears of CHS for CD204 is useful for a rapid confirmation of a cytologic diagnosis of CHS.