Miracle-dz/UniFAR-FTUs huggingface dataset:
Possibilistic Interorganizational Workflow Net for the Recovery Problem Concerning Communication Failures

In this paper, an approach based on interorganizational WorkFlow nets and on possibilistic Petri nets is proposed to deal with communication failures in business processes. Routing patterns and communication protocols existing in business processes are modeled by interorganizational WorkFlow nets. Possibilistic Petri nets with uncertainty on the marking and on the transition firing are considered to express in a more realistic way the uncertainty attached to communication failures. Combining both formalisms, a kind of possibilistic interorganizational WorkFlow net is obtained. An example of communication failure at a process monitoring level that precedes the presentation of a paper at a conference is presented.
Opposing Effects of 15-Lipoxygenase-1 and -2 Metabolites on MAPK Signaling in Prostate

Human prostate tumors have elevated levels of 15-lipoxygenase-1 (15-LOX-1) and data suggest that 15-LOX-1 may play a role in the development of prostate cancer. In contrast, 15-LOX-2 expression is higher in normal rather than in tumor prostate tissue and appears to suppress cancer development. We recently reported that 13-(S)-HODE, the 15-LOX-1 metabolite, up-regulates the MAP kinase signaling pathway and subsequently down-regulates PPARγ in human colorectal carcinoma cells. To determine whether this mechanism is applicable to prostate cancer and what the effects of 15-LOX-2 are, we investigated the effect of 15-LOX-1, 15-LOX-2, and their metabolites on epidermal growth factor (EGF)- and insulin-like growth factor (IGF)-1 signaling in prostate carcinoma cells. In PC3 cells, 13-(S)-HODE, a 15-LOX-1 metabolite, up-regulated MAP kinase while in contrast 15-(S)-HETE, a 15-LOX-2 metabolite, down-regulated MAP kinase. As a result, 13-(S)-HODE increased PPARγ phosphorylation while a subsequent decrease in PPARγ phosphorylation was observed with 15-(S)-HETE. Thus, 15-LOX metabolites have opposing effects on the regulation of the MAP kinase signaling pathway and a downstream target of MAP kinase signaling like PPARγ. In addition to the EGF signaling pathway, the IGF signaling pathway appears to be linked to prostate cancer. 13-(S)-HODE and 15-(S)-HETE up-regulate or down-regulate, respectively, both the MAPK and Akt pathways after activation with IGF-1. Thus, the effect of these lipid metabolites is not solely restricted to EGF signaling and not solely restricted to MAPK signaling. These results provide a plausible mechanism to explain the apparent opposing effects 15-LOX-1 and 15-LOX-2 play in prostate cancer.
Imaging , Diagnosis , Prognosis Validation of a Proliferation-Based Expression Signature as Prognostic Marker in Early Stage Lung Adenocarcinoma

Purpose:New prognostic markers to guide treatment decisions in early stage non–small cell lung cancer are necessary to improve patient outcomes. In this report, we assess the utility of a predefined mRNA expression signature of cell-cycle progression genes (CCP score) to define 5-year risk of lung cancer–related death in patients with early stage lung adenocarcinoma. Experimental Design: A CCP score was calculated from the mRNA expression levels of 31 proliferation genes in stage I and stage II tumor samples from twopublicmicroarray datasets [Director’sConsortium(DC) andGSE31210]. The same gene set was tested by quantitative PCR in 381 formalin-fixed paraffin-embedded (FFPE) primary tumors. Association of the CCP score with outcome was assessed by Cox proportional
Design of 4:16 decoder using reversible logic gates

Reversible logic has received great importance in the recent years because of its feature of reduction in power dissipation. It finds application in low power digital designs, quantum computing, nanotechnology, DNA computing etc. Large number of researches are currently ongoing on sequential and combinational circuits using reversible logic. Decoders are one of the most important circuits used in combinational logic. Different approaches have been proposed for their design. In this article, we have proposed a novel design of 4:16.
A novel approach for data stream clustering using artificial bee colony algorithm

This paper presents a novel approach to effectively clustering a large amount of data stream produced by some applications such as large-scale surveillance, network packet inspection and stock market. Owing to the massiveness and forgotten characteristics of the data stream, the proposed approach uses a damped window model to partition them. Then it adopts modified K-means based on the Artificial Bee Colony (ABC) algorithm to cluster this data stream fragment and dynamically update the clustering result. Detailed simulation analysis demonstrates that this algorithm is of high efficiency of space and time and is more stable.
Possibilistic Activity Recognition

The development towards ambient computing will stimulate research in many fields of artificial intelligence, such as activity recognition. To address this challenging issue, we present a formal activity recognition framework based on possibility theory, which is largely different from the majority of all recognition approaches proposed that are usually based on probability theory. To validate this novel alternative, we are developing an ambient agent for the cognitive assistance of an Alzheimer’s patient within a smart home, in order to identify the various ways of supporting him in carrying out his activities of daily living.
All you Need is Merge : Biology , Computation , and Language from the Bottom-up

In recent years, there has been a resurgence of activity surrounding biolinguistics along with a parallel, renewed interest in the connections between language and evolution. To be sure, from one standpoint it has often been said, quite correctly, that linguistic science just is biology: the study, however abstract, of a particular, apparently species-specific human trait: knowledge of language. But beyond this immediate point, how might linguistics and biology, especially evolutionary biology, inform one another? How does one go about making a proper evolutionary argument? What can genomics and evolutionary biology tell us now about language, and what might be out of reach, now, or out of reach forever, and why? To answer such questions, this chapter attempts to clear up some possible misunderstandings about evolutionary thinking that one might dub “vulgar Darwinism”—that is, the popular versions of evolutionary theory that sometimes find their way into analyses about language and evolution. The bottom line is that proper evolutionary explanations are often much more difficult to execute than one might think, and that language is a particularly difficult, even uniquely difficult, case to crack. Like linguistics, there is a substantial body of knowledge and theory grounding modern evolutionary analysis, with subtleties that are often missed, even by biologists themselves.
Practicing Safe Computing: A Multimedia Empirical Examination of Home Computer User Security Behavioral Intentions

Although firms are expending substantial resources to develop technology and processes that can help safeguard the security of their computing assets, increased attention is being focused on the role people play in maintaining a safe computing environment. Unlike employees in a work setting, home users are not subject to training, nor are they protected by a technical staff dedicated to keeping security software and hardware current. Thus, with over one billion people with access to the Internet, individual home computer users represent a significant point of weakness in achieving the security of the cyber infrastructure. We study the phenomenon of conscientious cybercitizens, defined as individuals who are motivated to take the necessary precautions under their direct control to secure their own computer and the Internet in a home setting. Using a multidisciplinary, phased approach, we develop a conceptual model of the conscientious cybercitizen. We present results from two studies-a survey and an experiment-conducted to understand the drivers of intentions to perform security-related behavior, and the interventions that can positively influence these drivers. In the first study, we use protection motivation theory as the underlying conceptual foundation and extend the theory by drawing upon the public goods literature and the concept of psychological ownership. Results from a survey of 594 home computer users from a wide range of demographic and socio-economic backgrounds suggest that a home computer user's intention to perform security-related behavior is influenced by a combination of cognitive, social, and psychological components. In the second study, we draw upon the concepts of goal framing and self-view to examine how the proximal drivers of intentions to perform security-related behavior identified in the first study can be influenced by appropriate messaging. An experiment with 101 subjects is used to test the research hypotheses. Overall, the two studies shed important new light on creating more conscientious cybercitizens. Theoretical and practical implications of the findings are discussed.
CTG trinucleotide repeat variability in identical twins with myotonic dystrophy

Myotonic dystrophy (DM) is an autosomal dominantly inherited disorder with a highly variable expression and a wide range of symptoms. The inheritance of this disorder has been found to be associated with the unstable elongation of a (CTG), motif in the 3' untranslated region of protein kinase gene fiamily member on chromosome 19 [I, 21. A positive correlation between earlier onscdgreater severity and increasing (CTG), repeat number has been reported 131. More-over, there is also a tendency toward an intergenerational expansion of the repeat length underlying the phenomenon of anticipation [4]. Mitotic instability of the repeat has been discussed, but there are relatively few reports comparing the pattern of expansion in monozygotic twins [5, 61. We report the results ohpained in the study of two sets of twins where monotygosity was established with 93.78% and 99.80% certainty, respectively, using eight polymorphic DNA markers.
Functional Proteomics Study Reveals That N-Acetylglucosaminyltransferase V Reinforces the Invasive/Metastatic Potential of Colon Cancer through Aberrant Glycosylation on Tissue Inhibitor of Metalloproteinase-1*S

N-Acetylglucosaminyltransferase-V (GnT-V) has been reported to be up-regulated in invasive/metastatic cancer cells, but a comprehensive understanding of how the transferase correlates with the invasive/metastatic potential is not currently available. Through a glycomics approach, we identified 30 proteins, including tissue inhibitor of metalloproteinase-1 (TIMP-1), as a target protein for GnT-V in human colon cancer cell WiDr. TIMP-1 was aberrantly glycosylated as characterized by the addition of β1,6-N-acetylglucosamine, polylactosaminylation, and sialylation in GnT-V-overexpressing WiDr cells. Compared with normal TIMP-1, the aberrantly glycosylated TIMP-1 showed the weaker inhibition on both matrix metalloproteinase (MMP)-2 and MMP-9, and this aberrancy was closely associated with cancer cell invasion and metastasis in vivo as well as in vitro. Integrated data, both of TIMP-1 expression level and aberrant glycosylation, could provide important information to aid to improve the clinical outcome of colon cancer patients.
Incentives and Characteristics that Explain Generic Prescribing Practices

This study uses the National Ambulatory Medical Care Survey (2006-2010) and Health Tracking Physician Survey (2008) to study the incentives and characteristics that explain physician generic prescribing habits. The findings can be characterized into four main categories: (1) financial/economic, (2) informational, (3) patientdependent and (4) drug idiosyncratic effects. Physicians in practices owned by HMOs or practices that had at least one managed care contract are significantly more likely to prescribe generic medicines. Furthermore, physicians who have drug industry influence are less likely to prescribe generic medicines. This study also finds consistent evidence that generic prescribing is reduced for patients with private insurance compared to self-pay patients. Drug-specific characteristics play an important role for whether a drug is prescribed as a generic or brand-name including not only market characteristics, such as monopoly duration length, public familiarity with the generic and the quality of the generic, but also non-clinical drug characteristics, such as the length of the generic name compared the length of the brand-name. In particular, the public’s familiarity with the generic has a large effect on the generic prescribing rate for a given drug. There are few differences between the generic prescribing habits of primary care physicians and specialists after controlling for the drugs prescribed. JEL Classification: I11; I13; I18; D82; D83.
The lung mycobiome in the next-generation sequencing era

ABSTRACT The fungi that reside in the human lungs represent an understudied, but medically relevant comm-unity. From the few studies published on the lung mycobiome, we find that there are fungi in both the healthy and diseased respiratory tract, that these fungi vary widely between individuals, and that there is a trend toward lower fungal diversity among individuals with disease. This review discusses the few studies of the lung mycobiome and details the challenges that accompany lung mycobiome studies. These challenges include sample collection and processing, sequence amplification and processing, and a history of multiple names for species. Some challenges may never be solved, but others can be solved with more data and additional studies of the lung mycobiome.
Aggression towards health care staff in a UK general hospital: variation among professions and departments.

BACKGROUND Aggression towards health care staff is an increasing problem and although many studies have examined psychiatric settings, few have considered general hospitals and in particular, variation among professions and locations. In addition, studies often fail to include all forms of aggression such as threatening behaviour and verbal aggression. METHODS This study extends existing research by evaluating physical assault, threatening behaviour and verbal aggression from patients/visitors towards general hospital staff in the context of different professions and departments. RESULTS AND CONCLUSIONS The survey of staff showed that aggression is widespread. Within the preceding year, 27% of the respondents were assaulted, 23% experienced threatening behaviour from patients and 15.5% experienced threatening behaviour from visitors. Over 68% reported verbal aggression, 25.7% experiencing it more regularly than monthly. By departments, over 42% of the medical department staff, 36% of the surgical staff and over 30% of the Accident and Emergency staff were assaulted. By profession, staff nurses and enrolled nurses reported the most assaults (43.4%) and doctors, the fewest (13.8%). Other nursing grades and health care professions all reported levels of physical assault in excess of 20%. Correspondingly high levels of threatening behaviour and verbal aggression were also reported although the patterns of victimization differed according to the various professions and departments. Independently, significant levels of assault, threatening behaviour and verbal aggression were reported. When aggregated they demonstrate the higher levels of victimization that general hospital staff experienced on a regular basis. RELEVANCE TO CLINICAL PRACTICE Institutional averages actually obscure the much higher levels of aggression experienced by the particular professions in particular departments. This study helps to localize the problem and identify those at most risk, but more research is needed into the aetiology of the aggression and of vulnerability factors associated with victimization.
Action spectroscopy of and D2H+ using overtone excitation

The ion and its deuterated isotopologues H2D+, D2H+ and play an important role in astrophysical and laboratory plasmas. The main challenge for understanding these ions and their interaction at low temperatures are state-specific experiments. This requires manipulation and a simple but efficient in situ characterization of their low-lying rotational states. In this contribution we report measurements of near infrared (NIR) absorption spectra. Required high sensitivity is achieved by combining liquid nitrogen cooled plasma with the technique of NIR cavity ringdown absorption spectroscopy. The measured transition frequencies are then used for exciting cold ions stored in a low-temperature 22-pole radiofrequency ion trap. Absorption of a photon by the stored ion is detected by using the laser-induced reactions technique. As a monitor reaction, the endothermic proton (or deuteron) transfer to Ar is used in our studies. Since the formed ArH+ (or ArD+) ions are detected with near unit efficiency, the stored ions can be characterized very efficiently, even if there are just a few of them.
Why do English players fail in soccer penalty shootouts? A study of team status, self-regulation, and choking under pressure

Abstract I examine why players from some nations appear always to choke in major international soccer penalty shootouts. Based on a model on choking under pressure as a type of self-defeating behaviour (Baumeister, 1997), I hypothesized that highly favourable public appraisals of a team would be linked to displays of escapist self-regulation strategies and inferior performance. I selected the eight most merited European nations, obtained videos from penalty shootouts in two major international tournaments (World Cup and European Championships), and analysed all 200 shots taken by players representing these teams. The results showed significant relationships between team status, self-regulation strategies, and performance. Players from countries that, at the time of the penalty shootout, either had many international club titles or featured many internationally decorated players, spent less time preparing their shots and were less successful from the penalty spot than players from countries with lower public status. England and Spain are used to illustrate these effects, as the data suggest that players from these two countries may have underperformed in previous international soccer tournaments because of high public status and misguided self-regulation strategies.
Cancer patients find quackery on the Web.

going, unpublished work, especially in public forums such as scientific meetings. "There is a lot of mistrust," Strong acknowledged. "There's even concern that if you submit a paper for review, a reviewer might be a competitor who could hold up your paper while he goes and replicates your work. " But fear of competition probably does not appreciably slow down the flow of information or the pace of progress, she added. Prospects for continued progress in medical research look bright for the short and long term. If application numbers are any indication, interest in medical schools, biomedical graduate schools, and advanced scientific training programs remains high. Strong also sees no decline in the quality of applicants. "I don't feel like medicine and science are getting the short shrift in the talent of students," she said. "I've heard a lot of predictions to that effect, but I certainly haven't seen any evidence of it. "
Shear-induced Reynolds stress at the edge of L-mode tokamak plasmas

The turbulent flux of momentum—or Reynolds stress—is a mechanism responsible for the generation of sheared flow by turbulence. The structure of the flux-surface-averaged stress is investigated in the edge region of an L-mode tokamak plasma. The stress induced by the perpendicular tilting of ballooning modes is considered. In addition to the tilting by the E × B flow shear, which is a negative viscosity effect, a magnetic-shear-induced Reynolds stress—called -residual stress—arises as a consequence of a residual spatial tilting of ballooning modes by the magnetic shear in a poloidally up–down asymmetric magnetic geometry. A model is derived in the weak flow shear regime under the approximation of circular flux surfaces. The amplitude of this residual stress is of the order of the square of the radial velocity fluctuations in the scrape-off layer (SOL), and in the immediate radial vicinity of the separatrix if an X-point exists. Its amplitude drops rapidly to zero towards the plasma core, thus appearing as a source of transverse rotation at the interface. Its non-linear dependence on the electric shear is discussed in the context of the weak electric shear effect on the poloidal shape of the ballooning envelope. The local -residual stress is non-uniform poloidally and changes sign according to the up/down position of SOL end-plates with respect to the ∇B × B direction. The electric- and magnetic-shear-induced stresses are then included in a flux-surface-averaged 1D model of mean flow conservation at the plasma edge, including the SOL volume. In L-mode weak shear regimes, it is shown that changing the plasma geometry from ∇B × B away from the divertor to ∇B × B towards the divertor approximately doubles the electric shear strength inside the separatrix, as reported in experiments. This shear-induced stress also enters the toroidal momentum balance, where it appears as a significant source of momentum in the immediate vicinity of the separatrix. Balanced by the toroidal viscosity only, it can sustain toroidal flow gradients of the order of a km s−1 cm−1 at the separatrix, with a sign also dependent on the plasma geometry. These momentum sources arising from symmetry breaking at the boundary of the confined region may explain why low to high mode power thresholds are lower in favourable than unfavourable configurations, and may be important for the issue of optimal plasma shapes with respect to edge intrinsic shear.
Acute Myocardial Infarction Associated with Ingestion of Herbal Mixtures Containing Acetylcholinesterase Inhibitors

We reviewed an unusual case of a 65-year-old male taking an herbal mixture containing compounds with anticholinesterase activity for a long period of time, presented with acute my myocardial infarction and multiple organ dysfunction syndrome followed by death. Clinically, there are findings correlated with anticholinesterase activity, such as bilateral miosis, diaphoresis, vomiting and fasciculation without a history of any toxic ingestion or exposure. Gas chromatography–mass spectrometry screening studies identified the presence of thymol, anethole in the herbal extract and butylated hydroxytoluene in the blood sample. Hence, with this case report, we intend to highlight the necessity of evaluating the longterm use of the herbal mixture. Keywords—Cholinesterase inhibitors, thymol, anethole, butylated hydroxytoluene, cardiac toxicity and myocardial infarction.
Efficient OFDM transmission without cyclic prefix over frequency-selective channels

We introduce a computationally efficient OFDM transmission technique that does not require a cyclic prefix and thus provides high spectral efficiency. The intersymbol interference (ISI) due to time dispersion of the channel is combated by ISI cancellation. We show that the inversion of the channel matrix for interchannel interference (ICI) cancellation can be done by the "operator perturbation technique" (OPT) much more efficiently than by conventional equation solvers. We supplement the OPT by blind techniques and hence reduce the error floor to zero for frequency-selective channels. The expense for a 2 Mbit/s transmission is about 500 MFlops. The technique can also deal with time-varying channels in a straightforward way.