Miracle-dz/UniFAR-FTUs huggingface dataset:
Survey on Unified Inter/Intrachip Optical Network for Chip Multiprocessors

As modern computing systems become increasingly complex, communication efficiency among and inside chips has become as important as the computation speeds of individual processing cores. Traditionally, to maximize design flexibility, interchip and intrachip communication architectures are separately designed under different constraints. Jointly designing communication architectures for both interchip and intrachip communication could, however, potentially yield better solutions. This paper presents unified inter/intrachip optical network called UNION, for chip multiprocessors (CMPs). UNION is based on recent progresses in nanophotonic technologies. It connects not only cores on a single CMP, but also multiple CMPs in a system. UNION employs a hierarchical optical network to separate interchip communication traffic from intrachip communication traffic. It fully utilizes a single optical network to transmit both payload and control packets. The network controllers on each CMP not only manage intrachip communications, but also collaborate with each other to facilitate interchip communications. It compared UNION with a matched electrical counterpart in45-nm process. The results for eight real CMP applications show that on average UNION improves CMP performance by 3×while reducing 88% of network energy consumption.
‘Maybe I will give some help…. maybe not to help the eyes but different help’: an analysis of care and support of children with visual impairment in community settings in Malawi

Abstract Background Visual impairment in children is common in low and middle‐income settings. Whilst visual impairment (VI) can impact on the development of children, many reach full potential with appropriate early intervention programmes. Although there is increased emphasis on early child development globally, it is not yet clear how to provide specific programmes for children with VI in low and middle‐income settings. This study aims to identify facilitators and barriers to the provision of a developmental stimulation programme for children with VI in rural and urban Malawi. Methods We undertook 6 focus groups, 10 home observations and 20 in‐depth interviews with carers of children with VI under 6 years in urban and rural Southern Malawi. We utilised topic guides relating to care, play, communication and feeding. Qualitative data were subject to thematic analysis that included placing themes within Bronfenbrenner's ecological framework. We established authenticity of themes through feedback from participants. Results We identified themes within Bronfenbrenner's framework at five levels: (1) blindness acting as a barrier to stimulation and communication, health and complex needs all affecting the individual child; (2) understanding of VI, ability to be responsive at the microsystem level of the carer; (3) support from other carers at microsystem level within a mesosystem; (4) support from other professionals (knowledge of, identification and management of children with VI, responsibilities and gender roles, environmental safety and prejudice, stigma and child protection all at the level of the exosystem. Discussion This study has revealed the requirements needed in order to produce meaningful and appropriate programmes to support nutrition, care and early stimulation for children with VI in this and similar African settings. This includes supporting carers to understand their child's developmental needs, how to better communicate with, feed and stimulate their child; offering advice sensitive to carers' responsibilities and professional training to better support carers and challenge community stigma.
Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise.

We determined whether increased glycolytic flux from hyperglycemia and hyperinsulinemia directly reduces fatty acid oxidation during exercise. Fatty acid oxidation rates were measured during constant-rate intravenous infusion of trace amounts of a long-chain fatty acid ([1-13C]palmitate; Pal) vs. a medium-chain fatty acid ([1-13C]octanoate; Oct). Six endurance-trained men cycled for 40 min at 50% of maximal O2 uptake 1) after an overnight fast ("fasting") and 2) after ingestion of 1.4 g/kg of glucose at 60 min and again 10 min before exercise (Glc). Glc caused hyperinsulinemia, a preexercise blood glucose of 6 mM, and a 34% reduction in total fat oxidation during exercise due to an approximately equal reduction in oxidation of plasma-free fatty acids (FFA) and intramuscular triglycerides (all P < 0.05). Oxidation of Pal was significantly reduced during Glc compared with fast (i.e., 70.0 +/- 4.1 vs. 86.0 +/- 1.9% of tracer infusion rate; P < 0.05). However, Glc had no effect on Oct oxidation, which is apparently not limited by mitochondrial transport. Furthermore, Glc reduced plasma FFA appearance 36% (P < 0.05), indicating a coordination of effects on adipose tissue and muscle. In summary, substrate oxidation during exercise can be regulated by increased glycolytic flux that is accompanied by a direct inhibition of long-chain fatty acid oxidation. These observations indicate that carbohydrate availability can directly regulate fat oxidation during exercise.
Kontrol: Hand Gesture Recognition for Music and Dance Interaction

This paper describes Kontrol, a new hand interface that extends the intuitive control of electronic music to traditional instrumentalist and dancers. The goal of the authors has been to provide users with a device that is capable of detecting the highly intricate and expressive gestures of the master performer, in order for that information to be interpreted and used for control of electronic music. This paper discusses related devices, the architecture of Kontrol, its potential as a gesture recognition device, and several performance applications.
Building UML class diagram maintainability prediction models based on early metrics

The fact that the usage of metrics in the analysis and design of object oriented (OO) software can help designers make better decisions is gaining relevance in software measurement arena. Moreover, the necessity of having early indicators of external quality attributes, such as maintainability, based on early metrics is growing. In addition to this, the aim is to show how early metrics which measure internal attributes, such as structural complexity and size of UML class diagrams, can be used as early class diagram maintainability indicators. For this purpose, we present a controlled experiment and its replication, which we carried out to gather the empirical data, which in turn is the basis of the current study. From the results obtained, it seems that there is a reasonable chance that useful class diagram maintainability models could be built based on early metrics. Despite this fact, more empirical studies, especially using data taken form real projects performed in industrial settings, are needed in order to obtain a comprehensive body of knowledge and experience.
To the Editor.

py The review was not prospectively registered. The search strategy appears uncomprehensive, (2) possibly explaining why studies inconsistent with their findings are not reported. Using exclusively the Oswestry Disability Index (3) rather than the parameter disability to exclude studies is unusual. Furthermore, this criterion is not applied consistently, with one study lacking a pain and disability measure being included in the review. The heterogeneity in the meta-analysis is extremely (4) high. Single-arm reviews do not consider natural history or (5) ‘‘placebo’’ effects related to study participation. Consequently, a more skeptical tone is warranted in discussing these results. Finally, the article does not appear to appreciate the (6) contemporary understanding of ‘‘pathology’’ in LBP. A weak correlation between disc degeneration and LBP development has been found in most studies. The idea that disc degeneration is a cause of LBP, which is then targeted with cell-based therapy, is a presumption not backed up with strong evidence. Therefore, this should be acknowledged.
Short-pulse radiation with low cross-polarization and a related new pulse ringing phenomenon in a printed antenna element covered by a polarization strip grating

Suppression of unwanted cross-polar radiation from a printed antenna element by placing a printed strip-grating on top is demonstrated for short-pulse radiation. It is discovered that an interesting pulse ringing can occur due to a new "grating resonance. " A full-wave analysis is outlined that models the effect of the strip grating placed on top of a microstrip antenna element and predicts the new pulse-ringing effect. <<ETX>>
A comparison of surgical resection and radiofrequency ablation for the treatment of single small hepatocellular carcinoma ≤2 cm

TB. Designing Clinical Research. Philadelphia, PA: Lippincott Williams & Wilkins; 2006. 3. Von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP; for the STROBE initiative. The Strengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370:1453-1457. 4. Huang JF, Yu ML, Huang CF, Chiu CF, Dai CY, Huang CI, et al. The efficacy and safety of pegylated interferon plus ribavirin combination therapy in chronic hepatitis c patients with hepatocellular carcinoma post curative therapies—a multicenter prospective trial. J Hepatol 2011;54: 219-226.
Urinary Tract Infections in Solid Organ Transplant Recipients

Epidemiology Urinary tract infection (UTI) is the most common infection in the renal transplant patient, the majority occurring in the first year following transplantation. Renal transplant patients have higher rates of UTI, hospitalizations and death due to Gram-negative septicemia associated with pyelonephritis, compared with patients on the renal transplant waiting list (1,2). Single center studies demonstrate that acute pyelonephritis, especially early posttransplant (3), represents a risk factor to long-term kidney graft function but does not affect graft survival at 5 years (4). Analysis of the United States Renal Data System (USRDS) database however, reveals that late UTI (>6 m after transplantation) is associated with poor renal allograft survival and increased mortality (5). Confounding factors that may contribute to renal allograft injury during UTI in the renal transplant patient include the combined effects of calcineurininhibitors with endotoxin (6,7), rejection (8) and recurrent UTI (5,9).
Acquired Resistance of Pancreatic Cancer Cells towards 5-Fluorouracil and Gemcitabine Is Associated with Altered Expression of Apoptosis-Regulating Genes

Objectives: Resistance to chemotherapy is a major cause of treatment failure and poor prognosis in pancreatic cancer. Inasmuch as most effects of chemotherapeutic agents are mediated via the activation of apoptosis, the cytotoxic effects of gemcitabine and 5-fluorouracil (FU) in correlation with apoptosis-regulating genes in pancreatic cancer cell lines were analyzed. Methods: The cytotoxic effects of 5-FU and gemcitabine in AsPC-1, Capan-1, Mia-PaCa-2 and T3M4 pancreatic cancer cell lines were assessed by growth assays, and mRNA expression levels of pro-apoptotic and anti-apoptotic genes of the Bcl-2 family were analyzed by RNAse protection assays. Results: Pancreatic cancer cells displayed a wide range of responses towards 5-FU (IC50 0.22–4.63 µM) and gemcitabine (11.51–42.2 nM). After repeated treatment with 5-FU, the IC50 values in Capan-1 and T3M4 cells increased 2.1- and 1.8-fold, respectively, compared to their parental cells. Following recurrent treatment with gemcitabine, the IC50 values in Capan-1 cells increased significantly (1.5-fold, p < 0.01). RNase protection assay showed a negative correlation between bcl-xL and mcl-1 mRNA expression levels and the sensitivity to 5-FU and gemcitabine after 5-FU and gemcitabine treatment. The bax/bcl-2 ratio maintained relatively stable following 5-FU/gemcitabine treatment and reflected the chemotherapeutic sensitivity of these cell lines. Conclusions: These findings reveal that pancreatic cancer cell lines are generally resistant to 5-FU and are more sensitive towards gemcitabine. The bax/bcl-2 ratio is predictive of chemotherapy sensitivity, whereas bcl-xL and mcl-1 mRNA levels following repeated exposure to 5-FU or gemcitabine are associated with resistance to these drugs. These findings suggest that the activation of anti-apoptotic genes after repeated drug exposure contributes to chemoresistance of pancreatic cancer cells and that blockage of anti-apoptotic genes might enhance chemosensitivity in pancreatic cancer.
Rheumatic diseases and Klinefelter's syndrome

The article summarizes reports on the concurrence of Klinefelter's syndrome (KS) with inflammatory rheumatic diseases, rheumatoid arthritis (RA), juvenile idiopathic arthritis, psoriatic arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, systemic sclerosis, mixed connective tissue disease, the antiphospholipid syndrome, and ankylosing spondylitis. These include two case reports of patients with KS concurrently associated with RA or antisynthetase syndrome, respectively, previously reported by the author and his coworkers. Attention is paid to the pathogenesis and the course of the disease in patients with KS. The importance of early diagnosis of the syndrome, when occurring simultaneously with other diseases of connective tissue, is emphasized.
VESICULOBULLOUS LUPUS ERYTHEMATOSUS WITH MILIAL FORMATION

A 38-year-old Hispanic man presented in February 1987 with an intensely pruritic widespread papulovesicular eruption tbat involved tbe elbows, knees, and sacral area and was most compatible with dermatitis herpetitormis (DH). Systemic lupus erythematosus (SLE) had been diagnosed 2 years prior on the basis ot a malar rash, polyarthralgias, alopecia, mild pleurisy, anemia, leukopenia, and positive serology. Skin biopsy demonstrated a subepidermal blister with polymorphonuclear cells (PMNL), leukocytoclasis, and neutropbilic, papillary microabscesses. Direct immunotluorescence (IF) of perilesional skin revealed bright and moderate continuous granular deposits of IgA and IgG, respectively, at the dermal-epidermal junction.
Generalized Diversity Reception in the Presence of Multiple Distinct Interferers: An Outage Performance Analysis

The analytical performance evaluation of various coherent diversity combining reception techniques in the presence of multiuser interference is presented into this paper. Particularly, the outage probability of the generalized selection combining (GSC) and its two extreme cases, namely the maximum ratio combining (MRC) and the selection combining (SC), are evaluated. The multiple interferers undergo independent and non-identically distributed Nakagami-m fading channels, with distinct average received powers and arbitrary fading scales. New analytical outage expressions are presented including several channel fading conditions regarding the desired user's signal. Although the proposed approach is formed as an infinite series representation, it includes only simple elementary and Gamma functions, while it delivers a rapidly converging formula achieving a sufficiently high precision level. Moreover, the derived computational complexity of this function is thoroughly discussed, while a corresponding comparison with another popular technique indicates the usefulness of the proposed approach. Finally, the accuracy of the approach is verified with the aid of selected numerical results accompanied with equivalent simulation ones.
IL2rg Cytokines Enhance Umbilical Cord Blood CD34+ Cells Differentiation to T Cells.

PURPOSE Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell (HSC) transplantation for the treatment of patients with leukemia if matched donor is not available. CD34+ is a pan marker for human hematopoietic stem cells, including umbilical cord blood stem cell. In comparison to other sources, cord blood CD34+ cells proliferate more rapidly and produce large number of progeny cells. For ex vivo expansion of Umbilical Cord Blood- HSCs/HPCs, different combinations of cytokines have been used in many laboratories. IL2rg cytokines, including IL2, IL7 and IL15, are key cytokines in the regulation of differentiation, proliferation and survival of immune cells. IL2 is important cytokine for T cell survival and proliferation, IL7 involve in B cell development and IL15 is a key cytokine for NK cell development. In this study we evaluated the generation of T cells derived from CD34+ and CD34- cord blood mononuclear cells by using combination of cytokines including IL2, IL7 and IL15. METHODS Cultured cord blood mononuclear cells were evaluated at distinct time points during 21 days by using flow cytometry. RESULTS Present study showed that differentiation of T cells derived from CD34+ cord blood mononuclear cells increased by using IL2 and IL7 at different time points. In the other hand IL15 did not show any significant role in generation of T cells from CD34+ cord blood mononuclear cells. CONCLUSION Taken together, our data illustrated that either IL2 or IL7 versus other cytokine combinations, generate more T cell from cord blood CD34 cells, probably this cytokines can be the best condition for ex vivo expansion of UCB HSCs.
Acute promyelocytic leukemia with unusual morphological features, absence of the t(15,17) and rearranged PML/RAR alpha genes.

cute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia with unique morphologic, cytogenetic, molecular and clinical features. Besides the classical hypergranular variant, there is also a cytological microgranular variant with significant clinical implications in both children and adults. Moreover, a basophilic form and a hyperbasophilic microgranular variant have been described, suggesting further morphological heterogeneity. t(15;17) is considered the specific cytogenetic marker for both the hypergranular and microgranular variants, and diagnosis of APL could be questionable in the absence of this cytogenetic abnormality. PML and RARa genes are involved by t(15;17) and their rearrangement is considered the molecular counterpart of the translocation. However, the existence of cases lacking this translocation but showing rearrangements of the PML/RARa genes has recently been reported. The availability of a more sensitive approach to APL diagnosis would obviously be of great importance in view of the thera-
Disaster‐Related Community Resilience: A Concept Analysis and a Call to Action for Nurses

&NA; A paucity of nursing literature is available on disaster‐related community resilience. Using a nursing method for analyzing concepts, this article attempts to clarify the meaning of this novel concept to encourage nursing research and practice. This concept analysis provides an introduction to the phenomenon of disaster‐related community resilience for nurses and consumers of nursing research. The article proposes the definition, antecedents, attributes, consequences, and empirical referents of disaster‐related community resilience and provides suggestions for nursing research and practice. It also provides nurses a foundation for participating in resilience‐building activities that may save lives and allow communities to recover more rapidly postdisaster.
Alveolar bone morphology under the perspective of the computed tomography : Defining the biological limits of tooth movement

Introduction: Computed tomography (CT) permits the visualization of the labial/buccal and lingual alveolar bone. Objectives: This study aimed at reporting and discussing the implications of alveolar bone morphology, visualized by means of CT, on the diagnosis and orthodontic treatment plan. Methods: Evidences of the interrelationship between dentofacial features and labial/buccal and lingual alveolar bone morphology, as well as the evidences of the effects of the orthodontic movement on the thickness and level of these periodontal structures were described. Results: Adult patients may present bone dehiscences previously to orthodontic treatment, mainly at the region of the mandibular incisors. Hyperdivergent patients seems to present a thinner thickness of the labial/buccal and lingual bone plates at the level of the root apex of permanent teeth, compared to hypodivergent patients. Buccolingual tooth movement might decentralize teeth from the alveolar bone causing bone dehiscences. Conclusion: The alveolar bone morphology constitutes a limiting factor for the orthodontic movement and should be individually considered in the orthodontic treatment planning. Abstract
Effect of broiler breeders fed with corn or sorghum and canthaxanthin on lipid peroxidation, fatty acid profile of hatching eggs, and offspring performance

&NA; The aim of study was to evaluate the effect on broiler breeders fed with corn or sorghum diets and canthaxanthin on lipid peroxidation, fatty acid, and offspring's performance. A total of 440 females with similar body weight (BW) (3.77 ± 0.11 kg) and 60 roosters were placed in an open‐sided house with 20 pens, randomly distributed in a factorial arrangement (2 × 2). There were 4 diets of 2 ingredients; corn (CO) or sorghum (SO) and 2 levels of canthaxanthin; 6 mg/kg (CX) and 0 mg/kg (NCX) totaling five replicate pens of 22 females and 3 males each, from 45 to 65 wk old. The BW was measured every 28 days, carotenoid concentration, thiobarbituric acid reactive substances (TBARS), fatty acid profile (%) in egg yolks, and the performance from two incubations and their offspring were evaluated. The study had the same statistical design as broiler breeders, making a total of 4 groups with 10 replicate pens of 8 chicks each. The BW and mortality were not affected (P > 0.05) by diets. Egg yolks coming from the CO diet had the highest (P < 0.05) lutein (3.8 vs. 0.49 mg/kg) and zeaxanthin (4.25 vs. 0.22 mg/kg) concentration compared to SO diet. The SO+CX diet had the highest CX concentration (P < 0.0001). The SO+CX diet showed the lowest TBARS (P = 0.0002) in the egg yolk compared to the CO+CX diet. Egg yolks coming from breeders fed with CO showed a higher concentration of saturated fatty acids (23.36 vs. 21.44%) and monounsaturated fatty acids (27.17 vs. 24.96%). Egg yolks arising from broiler breeders fed with SO diets showed a higher concentration of polyunsaturated fatty acids compared (15.29 vs. 12.88%). The CX reduced the offspring CO diets mortality and improved their viability at 64 wk‐old for the broiler breeders (P < 0.05). CX was well absorbed from the diet and effectively transferred to the egg yolk, thereby increasing its concentration in the yolk. This conferred resistance to oxidative stress to the yolk and also later to the developing embryo and its ultimate performance.
Rack-scale Computing (Dagstuhl Seminar 15421)

This report documents the program and the outcomes of Dagstuhl Seminar 15421 "Rack-scale Computing". The seminar was successful and facilitated interaction between researchers working in a diverse set of fields, including computer architecture, parallel workloads, systems software, and programming language design. In addition to stimulating interaction during the seminar, the event led to a follow-on Workshop on Rack-Scale Computing to be organized during 2016.