Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of lymph node metastasis in 200 patients with non-small cell lung cancer

Background Lymph node metastasis occurs although clinical stage IA is a relatively early stage for patients with non-small cell lung cancer (NSCLC). This study aimed to explore the influencing factors of lymph node metastasis. Methods A total of 200 patients diagnosed with clinical stage IA NSCLC preoperatively from July 2014 to July 2016 were examined. Every patient underwent lobectomy and systematic lymph node dissection. Their clinicopathological characteristics and status of lymph node metastasis are analyzed. Results The rates of both N1 and N2 lymph node metastasis increase with the increase in the tumor diameter. The N1 lymph node metastasis rate is 0%, 2.82%, and 9.52%, while the N2 lymph node metastasis rate is 0%, 4.23%, and 25.40% for pure ground-glass nodules, mixed ground-glass nodules (solid component <50%), and mixed ground-glass nodules (solid component >50%), respectively. The difference is statistically significant (P=0.000). Patients with squamous cell carcinoma have a relatively higher N1 lymph node metastasis rate comparing with patients with adenocarcinoma (P<0.05). Tumors locate in the inner half lobe (close to hilus) are prone to metastasize to lymph nodes (P=0.018). Multiple regression analysis shows that tumor diameter, solid component rate, and tumor location are relevant factors for lymph node metastasis. Conclusions In patients with NSCLC, who have tumors smaller than 1 cm, pure ground-glass nodules, or tumors locate in the lateral half lobe, lymph node metastasis is rare and selective lymphadenectomy is considerable.
An Efficient Host-to-Host Available Bandwidth Estimation Scheme

This paper takes an initiative from TOPP [3] and SLoPS [1]and its essence is to reduce the number of probing and error inherent in estimating the available bandwidth along a network path. This paper aims at proposing an algorithm for estimating available bandwidth with shorter measurement latency. Our method that is iterative generates new probing rates by proportionally decreasing an initial probing rate as a function of backlogged delays as a result of extra traffics along the path. The proposed algorithm, when implemented in ns2 under same simulation setup in TOPP; produced the available bandwidth estimate at about 30% of the number of iterations required for TOPP with a relative estimation error of 5% against 9% in TOPP.
A Free Virtual Reality Platform for Clinical Psychology and Behavioral Neurosciences: The NeuroVR Project

Virtual reality (VR) can be considered an embodied technology whose potential is wider than the simple reproduction of real worlds. By designing meaningful embodied activities, VR may be used to facilitate cognitive modelling and change. However, the diffusion of this approach is still limited by three main issues: poor usability, lack of technical expertise among clinical professionals, and high costs. To address these challenges, we introduce NeuroVR (http://www.neurovr.org – http://www.neurotiv.org), a cost-free virtual reality platform based on open-source software, that allows non-expert users to adapt the content of a pre-designed virtual environment to meet the specific needs of the clinical or experimental setting. Using the NeuroVR Editor, the user can choose the appropriate psychological stimuli/stressors from a database of objects (both 2D and 3D) and videos, and easily place them into the virtual environment. The edited scene can then be visualized in the NeuroVR Player using either immersive or nonimmersive displays. Currently, the NeuroVR library includes different virtual scenes (apartment, office, square, supermarket, park, classroom, etc.), covering two of the most studied clinical applications of VR: specific phobias and eating disorders. The NeuroVR Editor is based on Blender (http://www.blender.org), the open source, cross-platform suite of tools for 3D creation, and is available as a completely free resource. An interesting feature of the NeuroVR Editor is the possibility to add new objects to the database. This feature allows the therapist to enhance the patient’s feeling of familiarity and intimacy with the virtual scene, i.e., by using photos or movies of objects/people that are part of the patient’s daily life, thereby improving the efficacy of the exposure. The NeuroVR platform runs on standard personal computers with Microsoft Windows; the only requirement for the hardware is related to the graphics card, which must support OpenGL.
The Value of Doppler Study of Central Retinal Artery in Diagnosis of Increased ICP

Purpose: To evaluate the diagnostic value of CRA Doppler study in case of increased intracranial pressure. Methods: We used High Frequency Probe 8MH to study Central Retinal Arteries Doppler by oblique axial view. Case Report: A case of 32-year-old patient with a moderate Head injury and clear signs of Brain edema in CT [ bilateral frontal hemorrhage, sulci effacement, absent CSF in quadrigeminal Cisterna], also, Trans cranial U/S and ONSD revealed signs of increased ICP[ LT MCA PI 1.29, RT MCA PI 1.36, LT ONSD 0.62cm, RT ONSD 0.64]. We did complete Doppler study of both CRAs [color and spectral] in this patient during admission, both color and Spectral Doppler revealed absent of diastolic flow which was correlated with Brain edema in CT, and signs of increased ICP in TCD, moreover, repeating the test after 3 days of dehydrating measures and marked improvement of patient condition revealed marked improvement in color flow as well as normalization of CRA RI [0.5]. This improvement was correlated with normalization of PI in both MCAs. CRA is a superficial, easy accessible without bony obstacle like TCD and the learning curve of its Doppler study can be very steep, so it could has a big role in management of cases with increased ICP. Conclusion: The change of Doppler flow of CRA can give a good idea about the dynamic changes of ICP during management of Brain edema, this probably will need a big study.
ECOREGION Barents Sea SUBJECT Request by the Norwegian ministry of fisheries and coastal affairs: Evaluation of a rebuilding plan for coastal cod

The Norwegian coastal cod north of 62° N is recognized as a stock complex. Genetic studies indicate that some of the spawning components along the coast could be local stocks more or less isolated from coastal cod in adjacent areas. Subsequently, the coastal cod management faces two major challenges – those being, first, to keep the total stock complex at a productive level and second, to give protection to potentially vulnerable local stock components. Both of these challenges are addressed in this draft rebuilding plan for coastal cod. Moreover, the knowledge regarding local stocks should be more specified, due to the fact that the scientific advice provided has become increasingly more specific on these matters.
Online Advertising and Consumer Behavior in Tunisia

The aim of this study was to present new mediating and moderating variables in the relationship between online advertising and purchase intention as well as visiting the store. Therefore, a qualitative study of 17 Tunisian Internet users was conducted (semi-structured interview). Results showed that the lifestyle change and the disposition to visit the store are the mediating variables between these consequences and electronic advertising (purchase intention and visiting the store). Furthermore, the involvement with the product is the moderating variable between e-advertising and lifestyle change, including disposition to visit the store.
Clinical patterns and risk factors of vulvo-vaginal candidiasis among women of reproductive age attending a tertiary hospital in central India

27 Vulvo-vaginal Candidiasis (VVC) is the most common fungal infection in women of reproductive age. Data related to distribution and risk factors are very limited in India. This study was designed to observe the prevalence of VVC among women of reproductive age group, find the species of Candida causing such infection and find the risk factors associated with VVC. All female patients in the childbearing age group, fulfilling the clinical criteria of vaginitis, reported between January 2016 and June 2017 were included in this study. Standard procedures were followed to collect vaginal swabs. Culture and microscopic examinations were done to isolate Candida albicans and non-albicans Candida (NAC) from the specimens. Descriptive and analytic statistics was used to illustrate the basic and disease characteristics of the study participants. The odds-ratio (OR) associated with each potential risk factor at 95% confidence interval (CI) were calculated. All results were considered significant at P<0.05. Out of total 168 subjects, 32.7% showed pure growth of Candida species and NAC species were found to be predominant (65.4%) followed by C. albicans (34.6%). Maximum Candida positivity was found in age group 21-30 years (60%) compared to other age groups (P<0.05). Candida positivity was found to be higher among pregnant (45.0%) than non-pregnant (28.9%) women (P<0.05) suggests that pregnant women are twice at odds for developing VVC as compared to non-pregnant women. The higher positivity in patients of vaginal discharge with pruritus was found to be statistically significant (P<0.05). One in three patients was found to be positive for VVC and NAC was more prevalent as compared to candida albicans. This study concluded that pregnant women are at risk for VVC.
Physico-chemical characterization of urban aerosols from specific combustion 1 sources in West Africa at Abidjan in Côte d’Ivoire and Cotonou in Benin in the frame

32 Air pollution in West Africa has yet to be well characterized and was one of the principal 33 motivations of the “Air Pollution and Health” work package in the DACCIWA (Dynamics34 Aerosol-Chemistry-Cloud Interactions in West Africa) program. Intensive measurement 35 campaigns were performed in two West African capitals (Abidjan in Côte d’Ivoire and Cotonou 36 in Benin), in order to examine the size distribution of particulate matter (PM) and their chemical 37 composition (Elemental Carbon (EC), Organic Carbon (OC), Water-soluble organic carbon 38 (WSOC), Water-soluble inorganic ions (WSI) and trace metals). In this study, we characterize 39 PM from different sites in Abidjan which are representative of Domestic Fires (ADF), Traffic 40 (AT) and Waste Burning (AWB), as well as a Traffic site (CT) in Cotonou. These sites, 41 impacted by a large volumes of pollution, are representative of the main combustion sources in 42 south West Africa during the dry and wet seasons. To this end, intensive campaigns were run 43 in Abidjan and Cotonou in July (2015 and 2016) and January (2016 and 2017). 44 Results show a well-marked seasonality and inter-annual variabily and spatial 45 variabilities with PM levels higher than the WHO guidelines of 25μg/m. The average mass 46 concentrations during the wet season were 90.3, 104.1, 69.1 and 517.3 μg. m at the AT, CT, 47 AWB and ADF sites, respectively. The largest value at the ADF site is due to the contribution 48 of food smoking and roasting activities. In the dry season, concentrations increase to 141.3, 49 269.7 and 175.3 μg. m at the AT, CT and AWB sites respectively, whereas at the ADF site, 50 concentrations decrease to 375.7 μg. m. 51 The chemical aerosol mass closure shows that dust contributed to 25-65% of PM at both 52 the AT, CT and AWB sites, and 10-30% at the ADF site with a clear seasonal cycle. A large 53 variability in Particulate Organic Matter (POM) is observed, ranging from 37-68% at ADF, 2054 42% at AT, 10-34% at AWB and 15-22% at CT. The contribution of WSI to bulk PM (lower 55 than 20%) is 2-3 times larger in the wet season than the dry, except at the ADF site where no 56 season variation is observed. The most dominant species in the WSI fraction at ADF are 57 chloride (18-36% of the total ions), potassium (8-22%) and calcium (13-25%), while at the rest 58 of the sites, nitrate (21-36%), chloride (6-30%) and sulfate (9-20%) are dominant. At all sites, 59 the proportion of EC is twice as high in the dry season as in the wet season. Carbonaceous 60 aerosol (sum of EC and POM) and dust particles are the two major contributors to the coarse, 61 https://doi.org/10.5194/acp-2019-406 Preprint. Discussion started: 11 June 2019 c © Author(s) 2019. CC BY 4.0 License.
Finding Influencers in Social Networks

Social networking is part of the daily routine of millions of people around the world. Modern social networking platforms provide users with tools for creating and sharing textual content, pointers to other web content, photographs or videos. From the millions of users that these platforms have, one can also acknowledge that the activities of a selected number of users are more rapidly perceived than those of others, and that the content produced by them flows swiftly through the network. We call these users the influencers. Influencers generate trends and shape opinions in social networks, being crucial in areas such as marketing, advertising or opinion mining. In this work, we studied automated techniques for discovering influential nodes in such networks, and we experimented with two different types of social networks: (1) location-based social networks (LBSN), i.e., networks that include relationships between users in the network and between users and the locations they have visited, and (2) academic citation networks (ASN), i.e., networks that relate scientific papers according to their citations. We addressed the task of identifying the most influential users in LBSN, while for ASN we addressed the task of identifying the most important papers, and developed a framework to predict the future influence scores of papers. We can conclude that these techniques really assist us when trying to find the most influential nodes in a network, and that one can make accurate predictions of future influence scores with the framework that was developed.
owards construction of viral vectors based on avian coronavirus infectious ronchitis virus for gene delivery and vaccine development

Manipulation of the coronavirus genome to accommodate and express foreign genes is an attractive approach for gene delivery and vaccine development. By using an infectious cloning system developed recently for the avian coronavirus infectious bronchitis virus (IBV), the enhanced green fluorescent protein (EGFP) gene, the firefly luciferase gene and several host and viral genes (eIF3f, SARS ORF6, Dengue virus 1 core protein gene) were inserted into various positions of the IBV genome, and the effects on gene
Methodological Issues and Strategies in Clinical Research, Fourth Edition

Scientific knowledge is very special. This knowledge is based on the accumulation of empirical evidence and obtained through systematic and careful observation of the phenomenon of interest. At a very general level, the ways in which the observations are obtained constitute the methods of science. Yet, these methods can be considered at multiple levels, including the principles and tenets they are designed to reflect, a way of thinking and problem solving, and concrete practices that scientists use when actually conducting an investigation. This book draws on each of these levels because they work together and make for good science and scientific research. The purpose of this introductory chapter is to convey what methodology is, why it is needed, and the key tenets that guide what we do as scientists. These foci may seem obvious—after all, everyone knows what methodology is and why it is needed. Perhaps so, but the answers are not all so obvious. It is useful to give the rationale for what we do and why because it provides the common base we as psychologists and social scientists share with all of the sciences. Also, that base underpins all of the chapters that follow. Let us begin.
Neural Network-Based Automatic Jiju Poetry Generation

梁健楠,孙茂松,矣晓沅,杨成,陈慧敏,刘正皓 (清华大学计算机科学与技术系,清华大学人工智能研究院,清华大学智能技术与系统国家重点实验室, 北京,100084) liangjn16@mails.tsinghua. edu.cn 摘要:集句诗是中国古典诗歌的一种特殊体裁,是从前人的诗篇中选取已有诗句,再将其巧妙组合形成一首新诗, 是一种艺术的再创造形式。 集句诗的生成要求集辑而成的诗不仅合辙押韵, 而且有完整的内容、连贯的上下文和新 颖的主旨意境,对创作者的知识储备和诗词鉴赏能力有极高的要求。 本文基于计算机的海量存储和快速检索能力, 以及神经网络模型对文本语义较强的表示和理解能力,提出了一种新颖的集句诗自动生成模型。 我们的模型以数十 万首古人诗作为基础,利用循环神经网络(RNN)自动学习古诗句的语义表示,并设计了多种方法自动计算两句诗句 的上下文关联性。 根据用户输入的首句,我们的模型能够自动计算选取上下文语义最相关连贯的诗句进行集辑,从 而形成一首完整的集句诗。 自动评测和人工评测的实验结果都表明,我们的模型能够生成质量较好的集句诗,远远 超过基线模型的效果。 关键词 神经网络 中国古典诗歌 自动诗歌生成 中图分类号:TP391 文献标识码:A
Immune effects of b-glucan are determined by combined effects on Dectin-1 , TLR 2 , 4 and 5

Particulate b-glucans enhanced NF-jB expression in cell-lines co-expressing Dectin-1A-TLR4 and Dectin1B-TLR4, while soluble b-glucans only synergistically acted on Dectin-1A-TLR4. This was different with Dectin-1 co-expressing TLR2 and TLR5, which inhibited activation after particulate and soluble bglucan stimulation. The co-acting effect of extracellular TLR2, TLR4 and TLR5 and Dectin-1 by particulate and soluble b-glucan on cytokine production was confirmed in THP-1 macrophages. Dectin-1 activation by particulate b-glucans during TLR2 and TLR4 but not TLR5 blocking was shown to enhance the proinflammatory cytokines IL-6, IL-8 and TNF-a in THP-1 macrophages. This effect was stronger with particulate than with soluble b-glucan. The data demonstrate that b-glucans is an immune regulatory ligand for TLR2 and TLR4. 2017 Elsevier Ltd. All rights reserved.
Toward Integrated Clinical and Gene- Expression Profiles For Breast Cancer Prognosis: A Review Paper

Breast cancer patients with the same diagnostic and clinical prognostics profile can have markedly different clinical outcomes. This difference is possibly caused by the limitation of current breast cancer prognostic indices, which group molecularly distinct patients into similar clinical classes based mainly on the morphology of diseases. Traditional clinical-based prognosis models were discovered to contain some restrictions to address the heterogeneity of breast cancer. The invention of microarray technology and its ability to simultaneously interrogate thousands of genes has changed the paradigm of molecular classification of human cancers as well as shifting clinical prognosis models to a broader prospect. Numerous studies have revealed the potential value of geneexpression signatures in examining the risk of disease recurrence. However, most of these studies attempted to implement genetic-marker based prognostic models to replace the traditional clinical markers, yet neglecting the rich information contained in clinical information. Therefore, this research took the effort to integrate both clinical and microarray data in order to obtain accurate breast cancer prognosis, by taking into account that these data complement each other. This article presents a review of the development of breast cancer prognosis models, concentrating precisely on clinical and gene-expression profiles. The literature is reviewed in an explicit machine-learning framework, which includes the elements of feature selection and classification techniques.
Preschool teachers’ competencies for inclusive practice and partnership with parents – experiences from Croatia

The competencies preschool teachers need to acquire and the skills they need to develop have changed in the last few decades, turning them into professions which require continuous critical reflections, objective insights and acceptance of one’s own role in the inclusive practice. Preschool teachers are required to understand and know how to establish a close, trusting and accepting relationship with parents. They are also expected to be able to balance expectations, norms and requirements they put on themselves and parents. In order to achieve this, they should use the contemporary educational partnership procedures in their immediate inclusive practice. Given all that, the competencies for inclusive practice actually represent a continuous process which implies the ability to contribute to and build the corpus of the existing knowledge, as well as to develop the practical and reflective skills and professional attitudes. The aim of the current paper is to analyze the preschool teachers’ professional competencies for inclusive practices and partnerships with parents in the Croatian preschool facilities. With the help of a semi-structured interview, the examinees gave their opinions on the inclusive practice and partnership with parents, the type of cooperation with parents, and the way of acquiring competencies for maintaining partnership with parents.
CLASSIFYING BREAST CANCER STAGE USING NEURAL NETWORKS

The goal of the Camelyon17 challenge [1] is to accurately stage breast cancer from whole-slide images (WSI) stained with haematoxylin and eosin (H&E). Due to recent state of the art breakthroughs using deep neural network algorithms [2][3], we decided to use a VGG style network for this task [4]. We performed semantic segmentation using a VGG style network as described in [5] followed by some simple post-processing to predict each patients tumor stage.
EFFECTIVENESS OF DIFFERENT OBTURATION TECHNIQUES OF INTERNAL RESORPTIVE CAVITIES USING RADIOGRAPH AND STEREOMICROSCOPE-AN IN-VITRO STUDY

Dr.Piyush Gupta, Dr.Aparna Palekar, Dr.Basawaraj Biradar, Dr.S. Sai Kalyan, Dr.Kavisha Desai post gratudate student, Professor and H.O. D, Professor, Reader, Postgraduate Student Pravara Institute of medical sciences ABSTRACT: Aim of this study was to compare the quality of different obturation techniques in extracted human teeth with artificial internal resorptive cavities. Materials and method: 30 extracted human single rooted teeth were selected and access opening was done in each tooth. Cleaning and shaping procedure was done using ProTaper Universal (Dentsply) till F3. The teeth were sectioned horizontally 7mm from the apex and artificial resorption cavities were prepared on the canal using #5 round bur. The sectioned teeth were recemented using glue (resin-bond) guided with the help of a guide mark and specimens were mounted in acrylic block using separating medium. The teeth were then randomly divided into 3 groups of 10 teeth each based on the obturation technique used : Group I Cold lateral compaction technique, Group II Thermoplastisized gutta-percha technique (Calamus) and group III Cold flowable gutta-percha technique (Gutta Flow 2). Teeth were removed from the acrylic block and radiographed in buccolingual and mesiodistal direction to evaluate obturation quality at internal resorption cavities which was observed by 2 experienced endodontists. The teeth were re-sectioned at the previous level (7mm from the apex) and quality of obturation viewed under the stereomicroscope. The percentage of sealer, guttapercha & voids in internal resorptive cavities was calculated and analyzed statistically using Fisher Exact probability test. Results: Radiographic data indicated that the differences were significant between Group 1 & Group 2, i.e P=0.02 (P<0.05) and highly significant between Group 1 and group 3, i.e P=0.002 (P<0.05). Stereomicroscopic evaluation indicated that the difference was highly significant between Group1 and Group 2, i.e P=0.001 (P<0.05) and between Group1 and Group 3, i.e P=0.001 (P<0.05). The radiographic data as well as stereomicroscopic data indicated that there was no significant difference between Group 2 and Group 3, i.e P> 0.05. Conclusion: Thermoplasticized gutta-percha technique (Calamus) and Cold flowable gutta-percha technique (Guttaflow 2) showed better quality of obturation as compared to Cold lateral compaction technique.