Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary omega-3 polyunsaturated fatty acids and treatment of cancer

Global cancer incidence and mortality rates are high and elevating. Worldwide, it is estimated that the annual number of cancer diagnoses will promote to 22 million by 2032.1 In spite of progress made in cancer chemotherapy, advanced solid tumors consisting of advanced carcinomas, sarcomas, melanoma, and glioblastoms, yet show wide problems in their treatment and traditional therapeutic agents alone have not produced satisfactory long-term clinical outcomes.2,3 Also, in those cases which the tumor has seemingly been eliminated fully, micro-metastases of inactive tumor cells often result to relapse and to therapeutic failing. Hence, considering the problems of scape and survival to cancer progress, most oncologists have concluded that no unique therapy is enough to treatment of cancer.4,5
Bracing in clubfoot: do we know enough?

Abstract Purpose The Ponseti method is widely used in clubfoot treatment. Long-term follow-up shows high patient satisfaction and excellent functional outcomes. Clubfoot tendency to relapse is a problem yet to solve. Given the importance of bracing in relapse prevention, we ought to discuss current knowledge and controversies about bracing. Methods We describe types of braces used, with its advantages and disadvantages, suggesting bracing schedules and duration. We identify bracing problems and pinpoint strategies to promote adherence to bracing. Results When treating a clubfoot by the Ponseti method, the corrected foot should be held in an abducted and dorsiflexed position, in a foot abduction brace (FAB), with two shoes connected by a bar. The brace is applied after the clubfoot has been completely corrected by manipulation, serial casting and possibly Achilles tenotomy. Bracing is recommended until four to five years of age and needs to be fitted to the individual patient, based on age, associated relapse rate and timing when correction was finished. Parental non-adherence to FAB use can affect 34% to 61% of children and results in five- to 17-fold higher odds of relapse. In patients who have recurrent adherence problems, a unilateral lower leg custom-made orthosis can be considered as a salvage option. Healthcare providers must communicate with patients regarding brace wearing, set proper expectations and ensure accurate use. Conclusion Bracing is essential for preventing clubfoot relapse. Daily duration and length of bracing required to prevent recurrence is still unknown. Prospective randomized clinical trials may bring important data that will influence clinicians’ and families’ choices regarding bracing. Level of Evidence V
Modeling and Stability Analysis of a Communication Network System

In this work, the modeling and stability problem for a communication network system is addressed. The communication network system consists of a transmitter which sends messages to a receiver. The proposed model considers two possibilities. The first one, that messages are successfully received, while in the second one, during the sending process the transmitter breaks down and as a result the message does not reach the receiver. Timed Petrinets is the mathematical and graphical modeling technique utilized. Lyapunov stability theory provides the required tools needed to aboard the stability problem. Employing Lyapunov methods, a sufficient condition for stabilization is obtained. It is shown that it is possible to restrict the communication network system state space in such a way that boundedness is guaranteed. However, this restriction results to be vague. This inconvenience is overcome by considering a specific recurrence equation, in the max-plus algebra, which is assigned to the timed Petri net graphical model.
Fine-grained error detection techniques for fast repair of FPGAs

Field Programmable Gate Arrays (FPGAs) are reconfigurable hardware components that have found great commercial success over the past years in a wide variety of application niches. High processing throughput, flexibility and reduced design time are among the main assets of such devices, and are essential to their commercial success. These features are also valuable for critical systems that often face stringent performance constraints. Furthermore, the possibility to perform post-deployment reprogramming is relevant, as it allows adding new functionalities or correcting design mistakes, extending the system lifetime. Such devices, however, rely on large memories to store the configuration bitstream, responsible for defining the current FPGA function. Thus, faults affecting this configuration are able to cause functional failures, posing a major dependability threat. The most traditional means to remove such errors, i.e., configuration scrubbing, consists in periodically overwriting the memory with its desired contents. However, due to its significant size and limited access bandwidth, scrubbing suffers from a long mean time to repair, and which is increasing as FPGAs get larger and more complex after each generation. Reconfigurable partitions are useful to reduce this time, as they allow performing a local repair procedure on the affected partition. For that purpose, fast error detection mechanisms are required, in order to quickly trigger this localized scrubbing and reduce error latency. Moreover, precise diagnosis is necessary to identify the error location within the configuration addressing space. Fine-grained redundancy techniques have the potential to provide both, but usually introduce significant costs due to the need of numerous redundancy checkers. In this work we propose a fine-grained error detection technique that makes use of abundant and underused resources found in state-of-the-art FPGAs, namely the carry propagation chains. Thereby, the technique provides the main benefits of fine-grained redundancy while minimizing its main drawback. Very significant reductions in error latency are attainable with the proposed approach. A heuristic mechanism to explore the diagnosis provided by techniques of this nature is also proposed. This mechanism aims at identifying the most likely error locations in the configuration memory, based on the fine-grained diagnosis, and to make use of this information in order to minimize the repair time of scrubbing.
Cortical Bone Health in African Ancestry Men

As the population ages, more non-white men will develop osteoporosis and its associated fractures, yet little is known about skeletal aging in African ancestry men. Studies using quantitative computed tomography (QCT)-measured Bone Mineral Density (BMD) have exposed the incomplete nature of the current understanding of age-related bone loss. Furthermore, studies of the relationship between body fat and BMD have challenged the traditional paradigm that adiposity is beneficial for skeletal health. Moreover, even though cortical bone constitutes 80% of the skeleton, its epidemiology has rarely been described. To address these knowledge gaps, this dissertation examined the rates of change and correlates for cortical thickness, periosteal and endosteal circumferences, and torsional bone strength (SSI) at the radius and tibia in middle-aged and older African ancestry men from the Tobago Bone Health Study over an average follow-up period of 6.2 years. Secondly, inflammation markers — high sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL6) — were examined in relation to rates of change in cortical bone measures in both limbs. Lastly, total calf adipose tissue area (TAT) and its components, percentage subcutaneous (%SAT) and non-subcutaneous fat (%NSAT), were assessed in relation to changes in cortical bone measures at the tibia. The main findings were: endosteal expansion outpaced periosteal bone formation, such that there was net cortical thinning and reductions in SSI in both limbs. HsCRP was not associated with rates of change in cortical bone measures, while higher baseline serum IL6 was significantly associated with slower rates of loss of cortical BMD and SSI at both limbs. Higher calf TAT was associated with higher rates of cortical BMD loss at the tibia. Higher %SAT and % NSAT were associated with lower and higher rates of cortical BMD loss respectively Higher %SAT was also associated with significantly greater rates of periosteal expansion. These findings have public health significance due to their focus on an under-studied population, detailed description of changes and correlates of cortical bone structure, particularly periosteal circumference, which is a promising therapeutic target for osteoporosis. Moreover, the relationship between adiposity and skeletal health is especially timely considering the alarming rates of obesity worldwide.
Metabolic Syndrome: The Genetic Aspect

Open access (OA) refers to unrestricted access via the Internet to articles published in scholarly international journals such as the “Endocrinology and Metabolic Syndrome”. OMICS Publishing Group strongly supports this open access initiative and all articles published by OMICS Publishing Group are freely accessible to everyone immediately after publication. Some of the special features of OMICS group journals include digital formatting, audio listening, language translation and ability to share views on articles via social networking. “Endocrinology and Metabolic Syndrome”open access gives a worldwide audience larger than that of any subscription-based journal. Articles published in open access format are more likely to be cited than those that are not [1]. Due to this reason impact factor of open access journals is on the rise for the last couple of years [2]. Researchers in developing nations are more likely to access information published by OA journals. The knowledge and expertise of the editors and editorial board members of “Endocrinology and Metabolic Syndrome” ensures high quality research articles and allows for a comprehensive review of scholarly works that span broad spectrum of issues.
Implementation of functional precision medicine for anaplastic lymphoma kinase-rearranged non-small lung cancer

Anaplastic lymphoma kinase (ALK)-rearranged kinase drives non-small cell lung cancer (NSCLC) in 3–7% of patients and treatment consists of a broad range of approved inhibitors which are administered sequentially in case of resistance developing invariably after approximately 1 year of therapy. Besides the former standard tyrosine kinase inhibitor (TKI) crizotinib, the second-line ALK inhibitors alectinib, ceritinib, brigatinib, as well as the third-line lorlatinib are approved for the treatment of ALK-positive NSCLC patients. The main challenge is to find individual schemes of ALK inhibitors therapy which provide the best benefit for the patients. A host of ALK fusion partners, rearrangement variants and ALK mutations prevent a direct correlation of ALK alterations and sensitivity to specific TKIs within the framework of genomic precision medicine. However, recurrent ALK-positive NSCLC is an aggressive disease resulting in accumulation of tumor cells in pleural effusions which may be collected for in vitro sensitivity testing in a manner designated as functional precision medicine. Provided that these cells are present in sufficient numbers, they can be exposed to all possible drug candidates and their chemosensitivity tested in short-term proliferation assays. In addition to ALK-directed TKIs, cytotoxic drugs and inhibitors of non-target bypassing pathways may be included in the tests. In contrast to other trials in genome-guided precision medicine, a range of suitable therapeutics is available for modified ALK proteins. In summary, ALK-positive NSCLC with pleural effusions offer a unique model to develop, test and validate concepts of functional precision medicine.
Building shielding loss measurements and modelling at the 5 GHz band in office building areas

This paper presents narrowband path loss measurements carried out at the 5.1 GHz band. The focus has been on building-shielding loss in office-building areas. Both azimuth and elevation dependence have been studied. The measurement campaign was performed in a multi-storey building on three different floors in an indoor office environment. A helicopter was used to simulate a mobile satellite system feeder link position in orbit. A differential GPS receiver was used to track the helicopter trajectory. The obtained measurement data is compared to results predicted by a model showing a good agreement between them. The measured shielding loss varied in the interval from 10 to 45 dB with a harmonic average of 19.1 dB for the elevation measurements and 22.3 dB for the azimuth measurements.
A statistical model for the MM-wave indoor radio channel

A statistical multipath model is presented to characterize the multipath propagation properties of indoor radio channels which operate in the MM-wave frequency band. The model is derived from measurement data obtained in various typical indoor environments. The results of the statistical modeling agree closely to a discrete uncorrelated scattering model. The proposed model fits measurements well, is simple to use in performance analysis and simulation studies of MM-wave indoor radio links and is extendable to other environments. <<ETX>>
Massive gastrointestinal bleeding; never too old to be due to Meckel’s Diverticulum - A case report and literature review

Gastrointestinal (GI) bleeding is a very common medical problem encountered in the acute care setting, and is a major cause of admission to hospitals with about 300,000 patients admitted annually. Obscure GI bleeding, defi ned as persistent or recurrent bleeding following initial negative upper and lower endoscopy, represents approximately 5% of all GI hemorrhages. The small bowel is the most common source for obscure GI bleeding. Variable lesions of the small bowel can cause obscure GI bleeding, with tumors, Crohn’s disease and Meckel’s diverticulum being more common in young age group. Meckel’s diverticulum, the most common GI congenital malformation, is usually asymptomatic and incidentally found. It can present with GI bleeding, seen more in pediatric patients, and rarely in adult patients. Herein, we present a 45 years old female patient, presenting with massive obscure GI bleeding due to Meckel’s diveticulum. Case Report
Identification of Insilico Drugs and Drug Docking Studies on Hypothyroidism and Inferility Disorders in Human

INTRODUCTION Worldwide about one billion people are estimated to be iodine deficient; however, it is unknown how often this results in hypothyroidism [1]. In large population-based studies in Western countries with sufficient dietary iodine, 0.3–0.4% of the population has overt hypothyroidism. A larger proportion, 4.3– 8.5%, has subclinical hypothyroidism [2]. Of people with subclinical hypothyroidism, 80% have a TSH level below the 10 mIU/l mark regarded as the threshold for treatment [3]. Children with subclinical hypothyroidism often return to normal thyroid function, and a small proportion develops overt hypothyroidism (as predicted by evolving antibody and TSH levels, the presence of celiac disease, and the presence of a goiter)[4]. Women are more likely to develop hypothyroidism than men. In population-based studies, women were seven times more likely than men to have TSH levels above 10 mU/l. 2–4% of people with subclinical hypothyroidism will progress to overt hypothyroidism each year. The risk is higher in those with antibodies against thyroid peroxidase. Subclinical hypothyroidism is estimated to affect approximately 2% of children; in the adults subclinical hypothyroidism is more common in the elderly, and in Caucasians. There is a much higher rate of thyroid disorders, the most common of which is hypothyroidism, in individuals with Down syndrome and Turner syndrome [5]. Very severe hypothyroidism and myxedema coma is rare, with it estimated to occur in 0.22 per million people a year. The majority of cases occur in women over 60 years of age, although it may happen in all age groups [6]. Most hypothyroidism is primary in nature. Central/secondary hypothyroidism affects 1:20,000 to 1:80,000 of the population, or about one out of every thousand people with hypothyroidism [7].
TNO instance search submission 2011

The TNO instance search submission to TRECVID 2011 consisted of three different runs: one is using an exhaustive keypoint search, one is using a bag-of-visual-words approach and one is using open-source face-recognition software. Our run approaches: Briefly, what approach or combination of approaches did you test in each of your submitted runs? ՠall runs: video decoding using ffmpeg library, sampling every 25th frame. ՠF_X_NO_TNO-SURFAC2_1: standard SURF keypoint detection, exhaustive search. ՠF_X_NO_TNO-BOWCOL_2: standard SURF keypoint detection, bag-of-words using 256 prototypes from queries, indexing and querying using Lemur. ՠF_X_NO_TNO-SUREIG_3: face detection & recognition with Eigenface descriptors. What if any significant differences (in terms of what measures) did you find among the runs? In terms of average precision TNO run 1 significantly outperforms TNO run 2. Runs 1 and 3 differ only at the PERSON queries. Based on the results, can you estimate the relative contribution of each component of your system/approach to its effectiveness? The results of TNO run 3 show that face-recognition software can have a contribution to effectiveness for PERSON queries. Based on the difference between TNO runs 1 and 2 we can estimate that the contribution of choosing exhaustive keypoint search over bag-of-words with a small visual vocabulary build on the query set of images is high. Overall, what did you learn about runs/approaches and the research question(s) that motivated them? What we learned from our runs: using face-recognition software on this dataset can have a contribution if the queries contain large frontal faces. Exhaustive keypoint search significantly outperforms bag-of-words. One can build an image-retrieval system using open-source components.
Parallel Diagnosability Analysis with LTL-X Model Checking based on Petri Net Unfoldings

We present a framework that shows how components in parallel can infer the diagnosability property of the complete system (distributed and with multiple faults) from the diagnosability verification of each component synchronizing with a fault free versions of the other ones. Furthermore, we use existing efficient methods and tools, in particular parallel model checking based on Petri net unfoldings, to verifier diagnosability of such components.
THE POWER OF DIGITAL TECHNOLOGY: ACTIVE LEARNING APPROACH

Interactivity in instruction takes on a more complex meaning. In good instruction, interactivity refers to active learning, in which the learner acts on the information to transform it into new, personal meaning. In a constructivist sense, the learner co-constructs meaning by exploring an environment, solving a problem, or applying information to a new situation that he/she helps to define. The role of the teacher is to lecture less and instead direct the students in a direction that will allow the students to "discover" the material as they work with other students to understand the curriculum. Active learning can encompass a variety of techniques that include small group discussion, role-playing, hands-on projects, and teacher driven questioning. The goal is to bring students into the process of their own education. This paper examines the effectiveness of using active learning methods versus the traditional lecture method of learning as means for improving student performance and educational experience. Survey results imply that students enjoy the opportunity of interacting with the different methods used in the active learning method than the traditional lecture method. Students using these methods feel that they have more interaction and positive experience with their classmates and instructor enjoy the experience of using the interactive and active learning methods, and would recommend this learning experience to others. In the end, this study provides evidence that using the active learning approach helped students develop critical-thinking and problemsolving abilities.
Avanços em Reconhecimento de Fala para Português Brasileiro e Aplicações: Ditado no LibreOffice e Unidade de Resposta Audível com Asterisk

Automatic speech recognition has been increasingly more useful and feasible. When it comes to languages such as English, there are excellent speech recognizers available. However, the situation is not the same for Brazilian Portuguese, where the few recognizers for desktop dictation that existed, are no longer available. This dissertation is aligned with a goal of the Signal Processing Laboratory at the Federal University of Pará, which is the development of a complete automatic speech recognizer for Brazilian Portuguese. More specifically, the main contributions of this dissertation are: the development of some resources needed to build a speech recognizer such as transcribed audio database and speech API; and the development of two applications: one for desktop dictation and another for automatic service in a call center. The system developed in-house for automatic speech recognition in Brazilian Portuguese is called Coruja, and besides all the resources that makes automatic speech recognition in Brazilian Portuguese available, the Coruja also contains an API for application development using speech recognition. The application for desktop dictation is called SpeechOO. The SpeechOO enables dictation and text editing and formatting by voice for the LibreOffice Writer. Other contribution of this work is the use of Coruja in call centers. Coruja was integrated with the Asterisk software, which is the main open source software for call centers. The main application developed for automated service in call center was an interactive voice response which is deployed nationally and receives more than 3 thousand daily calls.
Realistic Single Cell Modeling - from Experiment to Simulation

This tutorial gives a step by step explanation of how one uses experimental data to construct a biologically realistic multicompartmental model. Special emphasis is given on the many ways that this process can be imprecise. The tutorial is intended for both experimentalists who want to get into computer modeling and for computer scientists who use abstract neural network models but are curious about biological realistic modeling. The tutorial is not dependent on the use of a specific simulation engine, but rather covers the kind of data needed for constructing a model, how they are used, and potential pitfalls in the process.