Miracle-dz/UniFAR-FTUs huggingface dataset:
A Field Study of On-Calendar Visualizations

Feedback tools help people to monitor information about themselves to improve their health, sustainability practices, or personal well-being. Yet reasoning about personal data (e.g., pedometer counts, blood pressure readings, or home electricity consumption) to gain a deep understanding of your current practices and how to change can be challenging with the data alone. We integrate quantitative feedback data within a personal digital calendar; this approach aims to make the feedback data readily accessible and more comprehensible. We report on an eight-week field study of an on-calendar visualization tool. Results showed that a personal calendar can provide rich context for people to reason about their feedback data. The on-calendar visualization enabled people to quickly identify and reason about regular patterns and anomalies. Based on our results, we also derived a model of the behavior feedback process that extends existing technology adoption models. With that, we reflected on potential barriers for the ongoing use of feedback tools.
[Apparently matured oocytes injected in telophase I have worse outcomes from assisted reproduction].

PURPOSE To evaluate the nuclear maturation stage and the presence of meiotic spindles of in vivo matured oocytes from infertile women undergoing stimulated cycles for intracytoplasmic sperm injection (ICSI) and compare intracytoplasmic sperm injection outcomes between oocytes in telophase I (TI) and metaphase II (MII), and the ones with and without visible meiotic spindle. METHODS A prospective and controlled study with 106 infertile patients who underwent ovarian stimulation for intracytoplasmic sperm injection purposes. Patients aged 38 years or less, with basal follicle stimulating hormone (FSH) less than 10 mIU/mL and body mass index (BMI) less than 30 kg/m². Were included patients presenting any systemic diseases, any active infection, smokers or patients who had been using hormonal medications and hormonal and nonhormonal anti-inflammatory drugs for the past two months prior to the assisted reproduction procedure were excluded. The oocytes with the first polar body extruded (in vivo matured oocytes) were imaged by polarization microscopy immediately before intracytoplasmic sperm injection and characterized according to nuclear maturation stage (telophase I and metaphase II) and to the presence of a meiotic spindle. We analyzed the fertilization rates, cleavage, number of good quality embryos on the second day (D2) from oocytes on telophase I versus those in metaphase II, and metaphase II visible spindle versus non-visible ones. Data were analyzed comparatively by Fisher's exact test. The level of significance was set at 5% in all analyses (p<0.05). RESULTS The meiotic spindles of 516 oocytes were imaged using polarization microscopy. From the 516 oocytes analyzed, seventeen were in telophase I (3.3%) and 499 (96.7%) in metaphase II. The oocytes injected in telophase I had significantly lower fertilization rates than those injected in metaphase II (53 and 78%, respectively) and produced no good quality embryos on day 2. When the oocytes with and without a visible meiotic spindle were compared, there was no significant difference in the intracytoplasmic sperm injection results. CONCLUSIONS Oocytes injected in telophase I showed lower fertilization rates when compared to those in metaphase II. It is possible that the analysis of oocyte nuclear maturation by polarization microscopy can be used as a predictor of fertilization after intracytoplasmic sperm injection.
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.

BACKGROUND The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood. METHODS The International Takotsubo Registry, a consortium of 26 centers in Europe and the United States, was established to investigate clinical features, prognostic predictors, and outcome of takotsubo cardiomyopathy. Patients were compared with age- and sex-matched patients who had an acute coronary syndrome. RESULTS Of 1750 patients with takotsubo cardiomyopathy, 89.8% were women (mean age, 66.8 years). Emotional triggers were not as common as physical triggers (27.7% vs. 36.0%), and 28.5% of patients had no evident trigger. Among patients with takotsubo cardiomyopathy, as compared with an acute coronary syndrome, rates of neurologic or psychiatric disorders were higher (55.8% vs. 25.7%) and the mean left ventricular ejection fraction was markedly lower (40.7±11.2% vs. 51.5±12.3%) (P<0.001 for both comparisons). Rates of severe in-hospital complications including shock and death were similar in the two groups (P=0.93). Physical triggers, acute neurologic or psychiatric diseases, high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications. During long-term follow-up, the rate of major adverse cardiac and cerebrovascular events was 9.9% per patient-year, and the rate of death was 5.6% per patient-year. CONCLUSIONS Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome. This condition represents an acute heart failure syndrome with substantial morbidity and mortality. (Funded by the Mach-Gaensslen Foundation and others; ClinicalTrials.gov number, NCT01947621.).
Graphene-lead zirconate titanate optothermal field effect transistors

We have developed a pyroelectric field effect transistor (FET) based on a graphene-lead zirconate titanate (PZT) system. Under the incidence of a laser beam, the drain current can be increased or decreased depending on the direction of the polarization of the PZT substrate. The drain current sensitivity of the optothermal FET can reach up to 360 nA/mW at a drain field of 6.7 kV/m more than 5 orders of magnitude higher than that of the photogating transistors based on carbon nanotube on SiO2/Si substrate. Graphene is an excellent component for pyroelectric FET due to its high optical transparency and conductance.
Gas tamponade and macular grid laser photocoagulation in the management of recurrent retinal detachment.

BACKGROUND AND OBJECTIVE To evaluate the efficacy of intraocular gas tamponade and macular grid laser photocoagulation to manage recurrent macular hole retinal detachment after an initially successful reattachment by gas tamponade in highly myopic eyes. PATIENTS AND METHODS Five patients with high myopia and macular hole retinal detachment were treated by gas tamponade at the initial operation. Gas tamponade and macular grid laser photocoagulation were performed to treat recurrent retinal detachment at the second surgery. Demographic information, anatomic reattachment of the retina, and final visual acuity were studied. RESULTS Final successful retinal reattachment at the end of follow-up was obtained in all five eyes. Improvement of postoperative visual acuity with respect to preoperative visual acuity was observed in all patients. CONCLUSION Intraocular gas tamponade and grid laser photocoagulation in the macula for the management of recurrent macular hole retinal detachment provides good long-term anatomic success and acceptable functional results.
Effect of Additives on Ozone‐Based Decomposition of Reactive Black 5 and Direct Red 28 Dyes

In this research, ozonation of Reactive Black 5 (RB5) and Direct Red 28 (DR28) under the presence of Na2SO4 and Na2CO3 used as textile additives was investigated. The effect of these salts on discoloration, degradation dynamics, and the composition of the final compounds were studied. Different systems were evaluated; such as RB5‐Na2SO4 (100 g/L), RB5‐Na2CO3 (30 g/L), RB5‐Na2SO4/Na2CO3 (100 g/L/30 g/L), and DR28‐Na2SO4 (10 g/L, 40 g/L, and 80 g/L) with dye concentrations of 50, 150, and 250 mg/L without pH adjustment. Discoloration of RB5 and DR28 with and without additives was determined by visible and UV (UV‐Vis) spectroscopy. Decomposition of the dyes and the dynamics of intermediates and final byproducts were followed by high performance liquid chromatography. The presence of additives accelerated discoloration and decomposition for both dyes (more than 50%). The accumulation of oxalic and formic acids was observed. Possible mechanism schemes of ozonation for both dyes are proposed.
Nauru and Mauritius: Barometers of a Global Diabetes Epidemic

Our studies of the secular rises in type 2 diabetes in the Pacific island of Nauru and Indian Ocean island of Mauritius have provided a barometer to predict the epidemic globally. There has been an almost 6-fold increase in the number of people with diabetes in the last few decades. The International Diabetes Federation (IDF) has reported that the number of people with diabetes will escalate from 285 million to 438 million between 2010 and 2030 and the number of persons with IGT will grow from 344 to 472 million. This means that by 2030, there will be over 900 million people globally with or at high risk of diabetes and its associated 2 to 3-fold cardiovascular risk. Diabetes is now a global epidemic with devastating health, social and economic consequences and one of the largest epidemics in human history. This is now imposing a huge burden on health-care systems and national economies.
Les thalattosuchia, crocodiles marins du mésozoïque : systématique phylogénétique, paléoécologie, biochronologie et implications paléogéographiques

Les thalattosuchia, crocodiles marins du mesozoique, sont connus dans les sediments depuis le debut du xixeme siecle. Le nombre plethorique d'especes creees (plus de 190) nous a amene a mettre en doute la validite de certaines. L'absence de caracteres diagnosiques clairement identifies ne permettait pas de preciser les relations phylogenetiques. L'etude synthetique de la biologie et de l'eco-ethologie des crocodiles actuels permet de mieux apprehender les phenomenes associes aux variations intraspecifiques. L'anatomie du complexe de la manducation et la croissance ontogenique des differentes structures craniennes sont analysees et detaillees. L'analyse morphologique des caracteres des thalattosuchia est essentiellement basee sur le materiel du callovien de la region de poitiers qui se caracterise par la precision de sa datation biochronologique et par son remarquable etat de conservation. L'etude biometrique et graphique est effectuee a l'aide de la quasi-totalite des cranes decouverts en europe. Ces analyses permettent de definir des caracteres diagnosiques puis de les tester grace a la connaissance des variations intraspecifiques chez les crocodiles actuels. Les modalites de la croissance du crane des thalattosuchia sont precisees. De nouvelles relations phylogenetiques sont proposees puis discutees. De nouveaux taxons sont crees, permettant ainsi a la systematique de mieux refleter la biodiversite de ces crocodiles marins. Un inventaire de toutes les decouvertes de thalattosuchia est etabli, tenant compte a la fois de la systematique, de la paleogeographie et de l'age des gisements. La correlation biochronologique des principales formations est proposee. Les capacites de dispersions sont precisees pour chacune des deux super-familles: teleosauroidea et metriorhynchoidea. Ces nouvelles hypotheses permettent d'apporter d'importantes precisions sur l'evolution de la paleogeographie durant le jurassique
Web 2.0 and online learning and teaching : a preliminary benchmarking study

The context of online learning has been transformed by the advent of Web 2.0. While universities have just recently started to use Web 2.0 applications, these applications already exist in the students’ personal and educational world. Yet it is still not clear in what ways universities may be able to incorporate Web 2.0 applications in learning and teaching practices. This paper gives an overview of Web 2.0 applications for universities and discusses new opportunities that Web 2.0 has brought for universities. Examples of how some universities have used these applications are then outlined and categorized. The paper also discusses some of the main issues with Web 2.0 applications and provides recommendations for resolving these issues.
Myocardial protection by the nitroderivative of aspirin, NCX 4016: in vitro and in vivo experiments in the rabbit.

BACKGROUND A new family of nitroderivatives of conventional non-steroidal anti-inflammatory drugs capable of releasing nitric oxide has been synthesized. Among these compounds, a nitroderivative of aspirin (NCX 4016), which displays antiplatelet and vasodilating activities, appears to have clinical potential in cardiac pathology related to coronary insufficiency. METHODS In this study the beneficial effects of NCX 4016 and aspirin were evaluated in vitro in a model of myocardial ischemia-reperfusion of the rabbit and in vivo in a model of acute myocardial infarction of the same animal species. RESULTS The NCX 4016 (from 1 x 10(-5) M to 3 x 10(-4) M) caused dose-dependent cardiac protection in isolated rabbit hearts subjected to low flow ischemia-reperfusion. Inhibition of 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha) generation and proportional reduction of creatine kinase (CK) activity at reperfusion was observed. Aspirin (1 x 10(-4)M) markedly worsened the post-ischemic ventricular dysfunction and this event was paralleled by a 63% increase in CK activity and abolition of 6-keto-PGF1alpha formation. Perfusion of the hearts with NG-monomethyl-L-arginine (1 x 10(-5) M) worsened the ischemia-reperfusion damage in perfused hearts. This event was prevented by prior treatment with NCX 4016 (1 x 10(-4) M) but not with aspirin (1 x 10(-4) M). Ligation of the first antero-lateral branch of the left coronary artery in rabbits resulted in acute myocardial infarction with a mortality rate of 60% at 24 hours. NCX 4016 (0.5 mg/kg/min for 2 hours) significantly reduced the mortality rate by 10%, protected the rabbits against electrocardiogram derangement and almost abolished CK activity in plasma and myeloperoxidase activity in cardiac tissue. Aspirin was devoid of any protective activity. CONCLUSIONS In the rabbit NCX 4016 appears to exert a relevant cardioprotection likely mediated by nitric oxide donation. These results suggest that this nitroderivative of aspirin may lead to innovative therapy in myocardial ischemia and infarction.
In vitro and in vivo Activities of a New Lead Compound I2906 against Mycobacterium tuberculosis

Background: Due to the long duration of treatment and the emergence of multidrug-resistant strains, new antitubercular agents are urgently needed. I2906, as a novel lead, was screened and tested for efficacy in vitro and in vivo. Methods:To determine the efficacy of I2906,the minimum inhibitory concentrations against Mycobacterium tuberculosis and cytotoxicity were tested, and its in vivo activities were assessed by administering it to mice infected with M. tuberculosis H37Rv or multidrug-resistant strain. Results:Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05). Conclusions: I2906 displayed potential antimicrobial activities against M. tuberculosis H37Rv and drug-resistant strains in vitro and in vivo, and could improve efficacy of isoniazid in vivo.
The level of anxiety and depression in the early puerperium - preliminary report

Summary Introduction: Childbirth is both joyful and stressful life event. This stressful life event results in different emotions occurring with different strength among new mothers, one of them is postpartum depression. However, postnatal depression received the predominance of research attention in recent years, several authors have pointed attention to the importance of distinguishing between postpartum depression and postpartum anxiety. Aim. The primary purpose of the presented research was to assess the level of anxiety and depression among women who were hospitalized after delivery. The second purpose was to determine if some additional factors influence the level of anxiety and depression. Material. The study was conducted on the sample of 46 women who had delivered infants in Gynecology - Obstetrics Clinical Hospital UM in Poznan, Poland in 2010. Method. Polish adaptations of standard questionnaires were used to measure variables such as anxiety (STAI), depression (BDI), styles of coping (CISS) and temperament (PTS). Additional data were collected using a questionnaire developed by the authors. Results. Statistical analysis assessed the level and frequency of anxiety (as a state and as a trait) and depression and associations between these factors as well as associations with additional variables (including: mode of delivery, styles of coping with stress and tempera- ment). Conclusions. The score in BDI in mothers after delivery was associated positively with emotion - oriented style of coping and anxiety as a state and as a trait and negatively with strength of inhibition processes. Anxiety as a trait was positively related to c-section.
New insights into the phylogenetic distribution and evolutionary origins of the septins

Abstract Until recently, it had appeared that the septin family of proteins was restricted to the opisthokont eukaryotes (the fungi and animals and their close relatives the microsporidia and choanoflagellates). It has now become apparent that septins are also present in several other widely divergent eukaryotic lineages (chlorophyte algae, brown algae, and ciliates). This distribution and the details of the non-opisthokont septin sequences appear to require major revisions to hypotheses about the origins and early evolution of the septins.
Internal control for real-time polymerase chain reaction based on MS2 bacteriophage for RNA viruses diagnostics

BACKGROUND Real-time reverse transcription polymerase chain reaction (RT-PCR) is routinely used to detect viral infections. In Brazil, it is mandatory the use of nucleic acid tests to detect hepatitis C virus (HCV), hepatitis B virus and human immunodeficiency virus in blood banks because of the immunological window. The use of an internal control (IC) is necessary to differentiate the true negative results from those consequent from a failure in some step of the nucleic acid test. OBJECTIVES The aim of this study was the construction of virus-modified particles, based on MS2 bacteriophage, to be used as IC for the diagnosis of RNA viruses. METHODS The MS2 genome was cloned into the pET47b(+) plasmid, generating pET47b(+)-MS2. MS2-like particles were produced through the synthesis of MS2 RNA genome by T7 RNA polymerase. These particles were used as non-competitive IC in assays for RNA virus diagnostics. In addition, a competitive control for HCV diagnosis was developed by cloning a mutated HCV sequence into the MS2 replicase gene of pET47b(+)-MS2, which produces a non-propagating MS2 particle. The utility of MS2-like particles as IC was evaluated in a one-step format multiplex real-time RT-PCR for HCV detection. FINDINGS We demonstrated that both competitive and non-competitive IC could be successfully used to monitor the HCV amplification performance, including the extraction, reverse transcription, amplification and detection steps, without compromising the detection of samples with low target concentrations. In conclusion, MS2-like particles generated by this strategy proved to be useful IC for RNA virus diagnosis, with advantage that they are produced by a low cost protocol. An attractive feature of this system is that it allows the construction of a multicontrol by the insertion of sequences from more than one pathogen, increasing its applicability for diagnosing different RNA viruses.
Beta-blockers for preventing stroke recurrence.

BACKGROUND Stroke affects 15 million people per year worldwide. Despite recent developments in acute stroke treatment, prevention remains very important. Stroke has a high rate of recurrence; therefore secondary prevention is also important. Many clinical approaches to control risk factors have been proposed. One of these approaches is the prescription of beta-blockers that have effects beyond the reduction of blood pressure, which can reduce the recurrence of stroke. OBJECTIVES To evaluate the efficacy of beta-blockers for preventing stroke recurrence and for reducing death and major vascular events in people with a previous stroke or transient ischaemic attack (TIA), and to determine their safety, particularly with regard to the development of diabetes mellitus. SEARCH METHODS We searched the Cochrane Stroke Group Trials Register (May 2014), the Cochrane Central Register of Controlled Trials (CENTRAL) and the Cochrane Database of Systematic Reviews (CDSR) (The Cochrane Library 2014, Issue 5), the Database of Abstracts of Reviews of Effects (DARE) (May 2014), MEDLINE (1966 to May 2014), EMBASE (1980 to May 2014), and Latin American and Caribbean Health Sciences Literature (LILACS) (1982 to May 2014). We also searched ongoing trials registers and reference lists. SELECTION CRITERIA Randomised controlled trials (RCTs) that included participants with previous stroke or TIA due to arterial thrombosis or embolism. The intervention was any beta-blocker versus control, or beta-blocker plus other treatment versus other treatment. DATA COLLECTION AND ANALYSIS Two review authors independently screened the trials identified, appraised quality, and extracted data. MAIN RESULTS We included two RCTs involving 2193 participants in the review. Both studies randomised participants to either beta-blocker (atenolol 5 mg) or placebo and were of a high methodological quality. We noted no statistical differences among the groups in risks of fatal and non-fatal stroke (risk ratio (RR) 0.94, 95% confidence interval (CI) 0.76 to 1.18). For other outcomes analysed (major vascular events, death from all causes, death from cardiovascular causes) , we observed no significant differences between the groups. There were minor blood pressure reductions in the intervention group. Neither of the included studies reported the occurrence of diabetes among their outcomes or assessed quality of life. Adverse events were significantly more frequent in participants taking atenolol than in those given placebo, and were the most common reason given for discontinuing treatment (RR 1.85, 95% CI 1.45 to 2.35). AUTHORS' CONCLUSIONS To date, no available evidence supports the routine use of beta-blockers for secondary prevention after stroke or TIA. More studies with larger samples are needed.