Miracle-dz/UniFAR-FTUs huggingface dataset:
Inviting Grief into Games: The Game Design Process as Personal Dialogue

This paper investigates how designers might initiate a dialogue with underrepresented groups, infusing design with individuals' personal stories and imaginations. It does so alongside the example of Jocoi, a game aiming at mediating the experience of loss and grief over a dead baby. Apart from being a taboo subject in general, there is no explanation for the absence of this fairly common experience in games. Drawing on the emotional worlds and tastes of individuals identifying as bereft parents, Jocoi involved a collaboration with an Austrian self-help group for affected parents. The stories of four informants then served as an initial orientation point marking out the direction of our ensuing game design process. Working out central themes, needs and concerns conveyed by the group, the aim was to address some of their emotional challenges appropriately through a game. The paper first presents a rationale for the chosen method of collaboration. Most importantly, we embrace a paradigmatic shift from game design as the production of meaning and emotion towards game design as facilitation or mediation. The second section will zoom in to the concrete tools and stages we used in our our facilitation process with Jocoi. It will trace key moments in moving from kick-off workshop to the final game. Finally, the ensuing discussion will highlight learnings for a broader understanding of introducing diversity into games. The question of appropriateness seems to be of particular importance for game designers. It is a matter of maintaining a balance between active listening and autonomous creative practice. The project is part of an ongoing PhD project on loss and grief in games.
Evaluation of in vitro anthelminthic activity of Leucas aspera extracts

A B S t r A c t Helminths infections are also among the most common infections in human, affecting a large proportion of the world’s population in developing countries and produce a global burden of disease. Pherithema posthuma a helminthes is commonly known as earth-worms, Leucas aspera herb is distributed throughout India. the anthelminthic property of Leucas aspera was evaluated using Pherithema posthuma as an experimental model. Piperazine citrate was used as the standard reference. earthworm belonging to control group showed paralysis time as 64.33 min and death time as 200 min. Among the various concentrations of aqueous extract tested, concenration at 250 mg/ml showed efficient anthelminthic activity and among all the concentrations ethanol extract tested, concentration at 250 mg/ml gave significant results. This investigation revealed that ethanol extract of Leucas aspera showed significant anthelminthic activity against Pheretima posthuma when compared aqueous extract. Ethanol extract also proved to be efficient than the standard drug. this investigation supported the ethnomedical claims of Leucas aspera as anthelminthic plant.
The Role of Health Locus of Control in Evaluating Depression and Other Comorbidities in Patients with Chronic Pain Conditions, A Cross‐Sectional Study

Chronic pain is significantly influenced by behavioral, cognitive, and emotional factors. Few studies have investigated the health locus of control (HLC)—one's belief regarding where control over one's health lies—as it relates to patients with chronic pain. The purpose of this prospective, cross‐sectional study was to examine the relationship between depression and health/pain locus of control (HLC) in adult patients with persistent pain.
Electro-chemical and biological properties of carbon nanotube based multi-electrode arrays

A novel class of micro-electrodes was fabricated by synthesizing high density carbon nanotube islands on lithographically defined, passivated titanium nitride conductors on a silicon dioxide substrate. Electrochemical characterization in phosphate buffered saline of these new electrodes reveals superb electrochemical properties marked by featureless rectangular cyclic voltammetry curves corresponding to a DC surface specific capacitance and a volume specific capacitance as high as 10 mF cm−2 and 10 F cm−3, respectively. These electrodes are also characterized by a slowly varying impedance magnitude over the range of 1 Hz to 20 kHz. High fidelity extracellular recordings from cultured neurons were performed and analysed to validate the effectiveness of the fabricated electrodes. The enhanced electrochemical properties of the electrodes, their flexible and simple micro-fabrication preparation procedure as well as their bio-compatibility and durability suggest that carbon nanotube electrodes are a promising platform for high resolution capacitive electrochemical applications.
Cheryl riChardson Catherine VoWell dolly lamBdin sCott WikGren Youth Physical Fitness : TEN KEY CONCEPTS

been a key objective of physical education for more than a century (Park, 1988). During this period physical education has evolved to accommodate the changing views on fitness and health. Epidemiological research has clearly demonstrated the health benefits of physical fitness and physical activity, both for youth and adults (U.S. Department of Health and Human Services [USDHHS], 1996, 2008). The high incidence of obesity among youth has also resulted in school programs being designed to increase physical activity and improve nutrition (American Alliance for Health, Physical Education, Recreation and Dance [AAHPERD], 2013a, 2013c). Finally, the link between regular physical activity and academic achievement has been more clearly defined in recent years (Centers for Disease Control and Prevention [CDC], 2010). All these factors have led to increased attention from medical groups, public health agencies, nonprofit foundations, and other national and international organizations. One of the most significant developments is the establishment of the Presidential Youth Fitness Program (PYFP), a partnership between the President’s Council on Fitness, Sports and Nutrition (PCFSN), the Cooper Institute, AAHPERD, the CDC, the Amateur Athletic Union (AAU), and the National Foundation on Fitness, Sports & Nutrition (NFFSN). The PYFP is a model for fitness education that includes the use of a health-related assessment, as well as educational and motivational tools to support teachers and empower students to adopt active lifestyles. Three core areas of focus for the PYFP are assessment, professional development, and motivational recognition (see Figure 1). The FITNESSGRAM® (FG) program, developed by an esteemed advisory board affiliated with the Cooper Institute in Dallas, Texas, is the adopted health-related assessment of the PYFP. Over the past 25 years FG has helped lead the transition toward
Computationally efficient algorithms for multiple fault diagnosis in large graph-based systems

Graph-based systems are models wherein the nodes represent the components and the edges represent the fault propagation between the components. For critical systems, some components are equipped with smart sensors for on-board system health management. When an abnormal situation occurs, alarms will be triggered from these sensors. This paper considers the problem of identifying the set of potential failure sources from the set of ringing alarms in graph-based systems. However, the computational complexity of solving the optimal multiple fault diagnosis (MFD) problem is exponential. Based on Lagrangian relaxation and subgradient optimization, we present a heuristic algorithm to find approximately the most likely candidate fault set. A computationally cheaper heuristic algorithm - primal heuristic - has also been applied to the problem so that real-time MFD in systems with several thousand failure sources becomes feasible in a fraction of a second. This paper also considers systems with asymmetric and multivalued alarms (tests).
Establishment, Maintenance, and In Vitro and In Vivo Applications of Primary Human Glioblastoma Multiforme (GBM) Xenograft Models for Translational Biology Studies and Drug Discovery

Development of clinically relevant tumor model systems for glioblastoma multiforme (GBM) is important for advancement of basic and translational biology. One model that has gained wide acceptance in the neuro‐oncology community is the primary xenograft model. This model entails the engraftment of patient tumor specimens into the flank of nude mice and subsequent serial passage of these tumors in the flank of mice. These tumors are then used to establish short‐term explant cultures or intracranial xenografts. This unit describes detailed procedures for establishment, maintenance, and utilization of a primary GBM xenograft panel for the purpose of using them as tumor models for basic or translational studies. Curr. Protoc. Pharmacol. 52:14.16. 1‐14.16. 23. © 2011 by John Wiley & Sons, Inc.
Sıcaklık Stresi Oluşturulan Broylerlerde Rasyona İlave Edilen Bitki Ekstraktının Büyüme Performansı ve İnce Bağırsak Villusları Üzerine Etkisi

Bu calismada, sicaklik stresi altinda yetistirilen broyler rasyonlarina antibakteriyel etkili bitki ekstrakti (Herbromix®) katkisinin buyume, yemden yararlanma ve intestinal villuslarin uzunluklari uzerine etkisinin belirlenmesi amaclandi. Bu amacla yumurtadan yeni cikmis 80 adet broyler civciv kullanildi. Civcivler her grupta 20 adet olacak sekilde 4 gruba ayrildi. Gruplardan ikisine ticari broyler yemi verilirken diger ikisinin ticari yemlerine bitki ekstrakti (% 0,1) ilave edildi. Calismanin 15. gununden itibaren 30. gune kadar ticari yemle ve bitki ekstrakti ilave edilen yemle beslenen gruplardan birer tanesine sicaklik stresi uygulandi. Haftalik canli agirlik artisi ve yem tuketimleri takip edildi. Stres uygulamasinin sonunda (30. gun) ve 45. gunde bagirsak villuslarinin uzunluklari, 45. gunde karkas agirliklari ve bagirsak agirliklari olculdu. Kullanilan bitki ekstraktinin buyume performansi ve yem tuketimi uzerine onemli bir etkisinin olmadigi, bagirsak villus uzunluklarini ise kisalttigi gozlendi.
Auditory temporal-order thresholds show no gender differences.

PURPOSE Several studies on auditory temporal-order processing showed gender differences. Women needed longer inter-stimulus intervals than men when indicating the temporal order of two clicks presented to the left and right ear. In this study, we examined whether we could reproduce these results in order to further investigate the differences in auditory processing between men and women. METHODS Neurologically healthy subjects (13 males and 13 females, age range: 19 to 37 years) had to identify the temporal order of two clicks, presented monaurally to the left and right ear. Thresholds for the inter-stimulus intervals between the clicks were determined using a three step transformed up-down procedure. RESULTS The results show no influence of gender in the auditory temporal-order task. Inter-individual differences were, however, large, ranging from a threshold of around 15 ms to around 90 ms. CONCLUSION Contrary to what was found in previous studies, no significant gender difference was measured in temporal-processing abilities using a task with monaurally presented clicks.
HOG on the Promoter: Regulation of the Osmotic Stress Response

Members of the mitogen-activated protein (MAP) kinase family regulate transcription through phosphorylation of specific transcription factors. New studies indicate that this process may be more complex than previously anticipated. The yeast Hog1 protein kinase (a homolog of the mammalian p38 MAP kinase) interacts with transcription factors and perhaps with the general transcription machinery at target promoters. Chellappan discusses the recent results and their implications for understanding control of transcription by stress-activated MAP kinases.
The effect of manipulation in energy allowance during the rearing period of heifers on hormone concentrations and milk production in first lactation cows.

Fifteen Holstein heifers that were 175 +/- 4.0 d old and at BW of 175 +/- 4.9 kg were used to determine the effect of three feeding regimens from 6 to 12 mo of age on growth, blood concentration of several hormones, and milk production during first lactation. The feeding regimens consisted of two periods, the first lasting for 4 mo and the other for the subsequent 2 mo. For group A (restricted) heifers, the diet during period 1 was restricted to 85% of NRC (1988) recommendations (a daily BW gain of .7 kg); during period 2, a high energy, high protein diet was provided for ad libitum intake. Group B (control) heifers received a diet that corresponded to 100 and 90% of the NRC (1988) recommendations in periods 1 and 2, respectively. Group C (ad libitum) intake heifers received a high energy, high protein diet throughout both periods. Daily BW gains of heifers of groups A, B, and C were, respectively, . 625, . 768, and 1.100 kg for period 1 and 1.162, . 705, and . 797 kg for period 2. The different feeding regimens influenced the age at which the heifers achieved puberty but did not affect BW at puberty. Milk production during 250 d of lactation was 7056, 6070, and 5975 kg for groups A, B, and C, respectively. A statistical model that included serum derived mitogenic activity and serum prolactin of period 2 accounted for 63% of the difference in milk production at first lactation.
بهبود ساخت مدل شکل آماری بافت­های غیرصلب با کمک الگوریتم Coherent Point Drift

مدل­های شکل آماری، از اطلاعات آماری جهت تفسیر و بررسی شکل استفاده می­کنند. اطلاعات آماری شامل میانگین و واریانس نقاط متناظر شکل­های مجموعه آموزش است. یافتن نقاط متناظر دربین نقاط اعضای مجموعه­ی آموزش، یکی­از چالش­های مهم در ساخت مدل شکل آماری است. درین مقاله، از روش CPDجهت یافتن تناظر بین نقاط استفاده شد. درین روش، با ترکیب تناظر فازی، الگوریتم سرد شدن معین و انطباق غیرصلب دو شکل، تناظر بین نقاط به دست آمد. پس­از یافتن نقاط متناظر، مدل شکل آماری با یک تبدیل صلب ایجاد شد. ارزیابی روش پیشنهادی با استفاده­از میزان فشردگی، قابلیت تعمیم و اختصاصی بودن انجام شد. مدل ساخته شده به کمک روش پیشنهادی با مدل­های ساخته شده به روش­های TPS-RPM، ICP ،MDL مقایسه شد. نتایج نشان می­دهد که مدل پیشنهادی در معیار اختصاصی بودن با مقدار 06/0±21/0 مانند روش MDL عمل می­کند. در مورد معیارهای فشردگی و قابلیت تعمیم، نتایج به دست آمده با روش MDL مشابهت دارد. زمان متوسط اجرای الگوریتم در روش پیشنهادی 68 ثانیه است، در صورتی­که برای الگوریتم TPS-RPM390 ثانیه و برای الگوریتم MDL 3600 ثانیه است که برتری روش پیشنهادی را از نظر سرعت نشان می­دهد. هم­چنین در روش پیشنهادی، نسبت به روش­های ICP وTPS-RPM عملکرد بهتری به دست آمد.
An Inside Body Power and Bidirectional Data Transfer IC Module Pair

An IC module pair utilizing only three wires was designed for biomedical implants with a master unit (MU) and a small, lightweight satellite unit (SU). Power was delivered from the MU to the SU using a three-phase signal and converted to dc in the SU IC module by a passive MOS ac-dc converter. Bidirectional data transfer between the two units was achieved by modulating the amplitudes (at periods that do not affect power delivery) and the positions of the rising and falling edges of the three-phase signal. A bidirectional data rate in the range of MB/s and an overall power efficiency of 90.2% for a 2.84-mW load were achieved in a 0.18-μm CMOS process.
The Role of E-Selectin, P-Selectin, and Very Late Activation Antigen-4 in T Lymphocyte Migration to Dermal Inflammation1

T lymphocyte infiltration into inflamed tissues is thought to involve lymphocyte rolling on vascular endothelial cells. Because both selectin and α4 integrin adhesion molecules can mediate leukocyte rolling, the contribution of these receptors to lymphocyte migration to inflammation was examined. The recruitment of 111In-labeled spleen T cells to intradermal sites injected with IFN-γ, TNF-α, LPS, poly inosine-cytosine, and Con A was measured in the rat, and the effect of blocking mAbs to E-selectin, P-selectin, very late activation Ag-4 (VLA-4), and LFA-1 was determined on this T cell migration in vivo. Anti-E-selectin and anti-P-selectin mAbs each inhibited 10–40 and 20–48%, respectively, of the T lymphocyte migration to the inflammatory sites, depending on the stimulus. Blocking VLA-4 inhibited 50% of the migration to all of the lesions except Con A. Treatment with both anti-VLA-4 and anti-E-selectin mAbs inhibited up to 85% of the lymphocyte accumulation, while P-selectin and VLA-4 blockade in combination was not more effective than VLA-4 blockade alone in TNF-α, IFN-γ, LPS, and poly inosine-cytosine lesions. Inhibiting E-selectin, P-selectin, and VLA-4 together nearly abolished lymphocyte migration to all inflammatory sites. Anti-LFA-1 mAb strongly inhibited lymphocyte accumulation by itself, and this inhibition was not significantly further reduced by E- or P-selectin blockade. Thus, T cell migration to dermal inflammation is dependent on E-selectin, P-selectin, and VLA-4, likely because these three receptors are required for rolling of memory T lymphocytes, but VLA-4 and E-selectin are especially important for lymphocyte infiltration in these tissues.
OMIP‐012: Phenotypic and numeric determination of human leukocyte reconstitution in humanized mice

PURPOSE AND APPROPRIATE SAMPLE TYPES This panel was developed to determine both the frequency and absolute number of human leukocytes and leukocyte subsets present in the peripheral blood of humanized mice. The panel also provides information concerning the activation state of peripheral leukocytes by cell surface staining for HLA-DR and CD38, relevant to studies of HIV disease pathogenesis (1–3). This panel has been used with EDTA anticoagulated whole blood in conjunction with bead-based enumeration for quantitative assessment of human cell chimerism. This panel also works well for staining of peripheral blood mononuclear cells (PBMCs) prepared by density gradient centrifugation and for dispersed splenocytes. The multicolor panel described here has been used in studies of humanized mouse reconstitution (4) and longitudinal studies of HIV pathogenesis in NSG-BLTmice (5).
How much vitamin D is needed for healthy bones?

Vitamin D supplements are widely used to improve bone health, especially to prevent rickets in infants and children, and to reduce the risk of fractures in the elderly population. Therefore, it is one of the most frequently used ‘drugs’ in the world. A large RCT (VIDA) recently demonstrated that monthly doses of vitamin D3, equivalent to about 3000 IU per day for 3.4 years. , did not reduce the risk of nonvertebral fractures [1]. Fractures were only a secondary end-point, and the study was not fully powered to answer the question of antifracture efficacy. The authors now report the results of a substudy of the VIDA trial that looked into the effects of vitamin D supplementation on bone mineral density [2]. A monthly dose of 100 000 IU of vitamin D3 for 2 years given to 452 New Zealand adults (mean age 69 years.) with a baseline serum 25OHD concentration of 23 ng mL 1 did not significantly change BMD at the lumbar spine or total body, but attenuated the loss of BMD at the femoral neck and total femur by 0.5% (P < 0.05). In the subgroup with the poorest vitamin D status at baseline (<12 ng mL ), BMD at the lumbar spine and femoral neck remained unchanged whereas a 2% loss was recorded in the placebo group (P < 0.05). The authors concluded that untargeted vitamin D supplementation of elderly community-dwelling adults has no benefit for bone mass or reduction in fracture risks. However, they suggest that subjects with severe vitamin D deficiency may benefit from vitamin D supplementation. They also suggest that serum 25OHD of about 12–16 ng mL 1 may be a ‘trialbased’ definition of vitamin D deficiency [2]. How should these results be interpreted and translated into clinical practice?
What staging surgery should be performed on patients with uterine papillary serous carcinoma?

OBJECTIVE While uterine papillary serous carcinoma (UPSC) is an aggressive histologic subtype, it fortunately is not as common as some other histologic subtypes. Overall, patients with UPSC have a poor survival rate. Since the optimal surgical procedure to perform on patients with this tumor is unknown, the authors wanted to determine what the optimal surgical management of patients with UPSC should be. METHODS All patients with the preoperative or frozen section intraoperative diagnosis of UPSC were treated with a staging or cytoreductive procedure analogous to patients with serous carcinoma of the ovary. Patients analyzed underwent surgery from March 1983 to September 1995. RESULTS Sixty-five patients with UPSC were found. Twenty patients had FIGO stage I tumors, 6 stage II tumors, 8 stage III tumors, and 31 stage IV tumors. Twenty-nine patients had upper abdominal disease (17 gross disease and 12 microscopic disease only). Forty-eight patients underwent pelvic and paraaortic lymphadenectomy, with 6 of 48 having positive lymph nodes. All 14 patients with lymphovascular space invasion had stage IV disease. Thirty-one of sixty-five patients had positive cytology at the time of surgery. CONCLUSION Based on the clinical experience of these investigators, patients with UPSC should undergo a staging laparotomy similar to the procedure undertaken for patients with ovarian carcinoma. The surgery should include at least partial omentectomy, total abdominal hysterectomy and bilateral salpingo-oophorectomy, peritoneal washings, peritoneal biopsies, and pelvic and paraaortic lymphadenectomy similar to an ovarian cancer staging procedure if no gross disease > or =2 cm is found at time of surgery. If disease > or =2 cm is found, cytoreduction should be undertaken when feasible.
Concentration of nitrates in drinking water and its relationship with bladder cancer.

Environmental contamination is a characteristic of industrialized nations. The quality of public drinking water, particularly from underground reserves, has increasingly deteriorated. The fundamental cause of the contamination of underground water layers has been the growing worldwide use of nitrogen fertilizers and pesticides since the 1960s. The Valencian Community comprises three provinces on the East Mediterranean coast of Spain. Public drinking water in this community is obtained chiefly from underground sources. As a result, this area suffers the highest nitrates contamination of public drinking water recorded not only in Spain but in all of Europe. The aim of the present study was to investigate the existence of differences in the occurrence of bladder cancer between the population of Valencia province and the rest of the country. We studied the differences in bladder cancer incidence among populations exposed to different levels of nitrates in drinking water in the province of Valencia, as expressed in terms of relative risk. We found a statistically significant difference (p < 0.0001) between the occurrence of bladder cancer in the Valencia province and the rest of Spain, as reflected by the analysis of the corresponding regression curve slopes. Our analytical study revealed relative risks of over 1 in Valencia province in men and women, associated with the consumption of water containing a mean concentration of > 50 mg/L.