Miracle-dz/UniFAR-FTUs huggingface dataset:
Rat‐Liver Cholesterol 7α‐Hydroxylase

The establishement of the circadian rhythm of cholesterol 7α-hydroxylase activity requires protein and RNA synthesis. The spontaneous decrease of the enzymic activity, at the end of the night, allows us to evaluate a half-life time of about two hours. The half-life time goes up to about four hours when the enzymatic activity decay is measured following cycloheximide administration. This difference suggests that an active mechanism is involved in the control of the enzyme degradation. The daily variation of the enzyme activity is regulated via the hypothalamo-hypophysis-adrenal axis. At the cellular level glucocorticoids are the most likely responsible agent. The hepatic cholesterol 7α-hydroxylase variations always parallel the plasmatic corticosterone concentration fluctuations, the latter being by far the most important adrenocortical excretion product. These two rhythms are modified in a similar manner under different physio-pathological conditions, such as the inversion of lighting in the animal room or the inversion of feeding time. Of these two parameters, the moment of food intake is the most important and accounts for the synchronisation of the rhythm in the animals. The rhythm is retained after several days of starvation but its amplitude decreases and the individual variations among the animals increase significantly at each time point.
Decision Support for the Rolling Stock Dispatcher

This paper presents a simulation model to study the robustness of timetables of DSB S-tog a/s, the city rail of Copenhagen. Dealing with rush hour sce- narios only, the simulation model investigates the effects of disturbances on the S-tog network. Several timetables are analyzed with respect to robustness. Some of these are used in operation and some are generated for the purpose of investigating timetables with specific alternative characteristics.
Normalization of informal text for text-to-speech

A large amount of information is found in noisy contexts as texting and chat lingo have become increasingly prolific in the past decade. To take advantage of this vast knowledge resource, natural language processing techniques need to be adapted to work accurately on this unconventional data. This dissertation describes various noisy-channel approaches for the normalization of informal text, such as that found in emails, chat rooms, and SMS messages. In particular, two methods for the abbreviation modeling aspect of the noisy channel model are introduced: a statistical classifier using language-based features to decide whether a character is likely to be removed from a word, and a character-level machine translation model. A two-phase approach is used; in the first stage the possible candidates are generated using the selected abbreviation model and in the second stage the best candidate is chosen through decoding using a language model. Various combinations of the two methods are explored. The model is finally extended to decrease the number of false positives by using dictionary heuristics. Normalization accuracy for all systems is presented as well as both quantitative and qualitative results showing the effects of normalization on text-to-speech output. A significant decrease in word and phoneme error rates is achieved as well as an improvement shown using human perceptual tests. These contributions reflect an important step toward the development of improved text for automatic speech synthesis applications driven by informal text domain sources.
Related dependability problems in fault-tolerant and secure computer-systems

This paper expounds that the dependability problems encountered in the fault-tolerant and secure computing area appear to be diverse and enormous and that much research needs to be done in the area. The authors discuss: the relationship between reliability, safety and security in computer systems; faults, errors, and failures; and the problem areas.
Synthesis of Caprolactam using Ceria Impregnated and Cerium Ions Incorporated MCM-41Catalysts

Mesoporous siliceous MCM-41 was synthesized by hydrothermal method. Cerium incorporated MCM-41 was synthesized by hydrothermal method using Cetyltrimethylammonium bromide as template. Various weight percentage of Ceria was loaded over MCM-41 by wet impregnation method. The synthesized catalysts were characterized using FT-IR, TGA, DRS-UV-Vis, N2 sorption, SEM and TEM techniques. XRD confirmed the mesoporous structure of the catalysts. The catalytic activity of the ceria impregnated MCM41 was evaluated in the synthesis of caprolactam from cyclohexanone oxime in the liquid phase condition. At that temperature 4 wt. % Ce impregnated SiMCM-41 produced high conversion (76.2%) and percentage yield (66.4%). The impregnated catalyst may contain more number of cerium present in the pores, so the lewis acid sites will be more and the conversion of cyclohexanone oxime into caprolactam will be high.
Application of rule rewriting system to software automated tuning

This paper presents a technical report on development of auto-tuning framework TuningGenie for parallel programs performance acceleration. The framework works with source code of software and performs code-to-code transformations by utilizing facilities of rule-based rewriting system. Such approach gains higher flexibility comparing to existing solutions. This paper explains the framework's lifecycle, offers toolset for optimization, basics of architecture, and presents demo examples with results of tuning computationally complex parallel program.
Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people.

INTRODUCTION Insulin resistance is becoming an increasingly widespread problem worldwide. For its determination indirect indices of insulin resistance or insulin sensitivity have used. Those indices based on simultaneous measurements of blood glucose and insulin concentrations under fasting conditions or during the Oral Glucose Tolerance Test. OBJECTIVE The aim of the study was to estimate reliable reference values for the indices used in insulin resistance diagnosis. MATERIAL AND METHODS Materials and method. 191 selected participants, aged 18-31, were enrolled into the reference population. 130 participants from the reference population with fasting glucose ≤5.5 mmol/L, BMI<25 kg/m2, and without metabolic syndrome, were finally included in the reference group. The following insulin resistance indices were calculated: HOMA1-IR, HOMA2, HOMA2 from C-peptide, QUICKI, Matsuda Index and Insulin Secretion-Sensitive Index-2. Determination of reference intervals for indirect indices of insulin resistance was conducted in accordance with the C28-A3 procedure recommended by the Clinical & Laboratory Standards Institute (CLSI). RESULTS Results. The reference intervals for indirect insulin resistance indices examined according to CLSI protocol were: ≤4.00, ≤2.27, ≤4.10, ≥0.31 for HOMA1-IR, HOMA2, HOMA2 C-pep. , and QUICKI, respectively. For insulin sensitivity, the value of the Matsuda Index was established as ≥3.19 and for beta cell pancreatic function ISSI-2 as ≥206. CONCLUSIONS Conclusions. Establishing a reference intervals for these indices enable the proper identification and differentiation of the types of insulin resistance in particular populations. The early detection of metabolic disorders allows for introduction of effective preventive action.
Clostridium difficile: Antikörpertherapie und Impfungen

Abstract Hospital-acquired Clostridium difficile infections have become much more frequent in recent years. Besides treatment with antibiotics and fecal microbiota transplant, new preventive strategies are available now. Bezlotoxumab is an antibody against toxin B and may reduce the risk of relapse by roughly 10 %. Several vaccine candidates against toxins A and B and surface-associated antigens were immunogenic and are tested in clinical trials to investigate the efficacy and safety.
Call placement algorithm evaluation for integrated networks that overflow speech or data

As network providers implement multiple network types, including 2G and 3G networks and potentially 1G, WLL, and/or satellite, it becomes feasible to overflow traffic between these diverse networks. This results in an increase in capacity, because the Erlang model of traffic analysis shows that a large network provides efficiency of scale. This paper analyzes the gains in efficiency when dual mode phones may overflow to diverse networks, via handover, thus increasing the number of channels available to these phones and minimizing the blocking rate. The analysis compares different call handling models, via simulation and M-dimensional Markov chain models, which overflow speech and data calls between subnets.
Correctness analysis of Petri net based logic controllers

Petri nets are able to express the causality as well as the concurrency of a control algorithm. Signal interpreted Petri nets (SIPN) show good properties for model logic controllers. In SIPN the firing of a transition depends on input signals from the environment and the SIPN influences the environment via output signals. Since the function of a logic controller is basically determined by software, the question of software quality arises in this area. ISO/IEC 9126 defines six characteristics of software that can be used as quality criteria. In the six characteristics are set in the framework of controller design: the functionality and reliability of the software rely on the correctness of the algorithm. In this criteria for formal correctness of SIPN control algorithms are given, and it is shown how they can be evaluated using the SIPN reachability graph. Due to a close relation between sequential function chart (SFC) according to IEC 1131-3 standard [IEC 1992] and SIPN the criteria are also valid for SFC.
Epidemiology of Breast Cancer in a Single Institute in North India with High Incidence of Triple Negative Breast Cancers

1 Department of Radiotherapy and Oncology, Maharishi Markandeshwar Institute of Medical Sciences and Research (MMIMSR), Mullana, Ambala, Haryana, INDIA *Corresponding Author Hakim A Abstract Introduction: Carcinoma of breast is the most frequently diagnosed cancer in the most of the countries and is also the leading cause of cancer death. Breast cancer is the most common cancer in India with ASR incidence 24.7/100,000 and mortality 13.4/100.000. Triple Negative Breast Cancers (TNBC) are regarded as one of the malignant phenotypes, principally accounting for 12-25% of invasive breast cancers. Material and Methods: Patients data was collected from hospital registry in our Institute Maharishi Markandeshwar Institute of Medical Sciences and Research (MMIMSR), Mullana, Ambala in Haryana from period 2015 to Dec 2018. All diagnosed cases of breast cancer were included in study. A total of 153 cases were registered. All patients had pathological diagnosis. Out of 153 patients 83 patients had IHC available. Results: In this study 153 patients were reviewed. The median age of presentation was 50 years (range 3085). Around 27% patients were younger than 40 years. 52% patients were in age group 40-60 while 20% were above age 60. Most of patients had tumor size less than 5cm (38%) while 33% patients had tumor size more than 5cm. Majority of patients presented with lump in breast followed by pain and discharge. complete IHC done revealed ER positivity in 13.7%, PR positivity 12.4% and HER2 Neu receptor positivity in 10%. In this study incidence of TNBC is 43%. Majority of patients had Intraductal Carcinoma (>90%). Pathologically 57% patients had grade III tumor while 35% were grade II tumor. Incidence of TNBC is 43% in this study. Conclusion: Breast cancer is the most common cancer in India. In our study it was observed that most of the patients were 40-60 years age. Majority of the patients had grade III tumor. Incidence of TNBC was found to be higher in our study. Larger data is required for conclusive results.
On the Optimization of Message-Switching Networks

Criteria recently developed by the authors for optimum capacity assignment in message-switching networks are applied to a network model which now contains nodal processors as well as interconnecting links. Linear and stepped cost functions are examined and various performance and cost-performance curves are presented. An efficient design procedure is described for the tedious case of stepped cost functions. For general continuous cost functions and the minimax design the distribution functions of all point-to-point delays can be easily calculated.
Characterisation of blood vessels used for coronary artery bypass surgery

Saphenous veins are commonly used as coronary artery bypass grafts. Therefore, it is important to understand the vein wall morphology used for the bypass grafts. Methods. Ten specimens of saphenous veins were obtained from 10 patients admitted to the Heart Surgery Centre of P. Stradiņš Clinical University Hospital for coronary artery bypass surgery and a histopathological study was conducted. The slides were processed for histological routine and immunohistochemical staining with following markers: endothelin (ET), metallomembranoproteinase 2 (MMP2), tissue inhibitor of metalloproteinase 2 (TIMP2), transforming growth factor beta (TGF β), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), protein gene product 9.5 (PGP9.5), vascular cell adhesion molecule (VCAM), intercellular adhesion molecule (ICAM). For the analysis of the positive structures detected by immunohistochemistry, a semiquantitative evaluation method was used. Results. Normal histoarchitecture of the vein wall was evaluated by routine staining. Moderate positive endothelin containing endothelial cells and moderate to numerous positive VEGF cells were found on small blood vessels. Moderate positive MMP2 structures and variable – mainly moderate to numerous positive TIMP structures – were found in vein wall. Positive structures were evaluated as equal with both MMP2 and TIMP, with one exception where MMP2 positive structures were evaluated as moderate, but TIMP positive structures as few. All specimens were rich in TGFβ, VCAM and ICAM cells. Abundance of VCAM and ICAM positive endothelial cells was also found. Few HGF positive structures were found in tunica intima and few PGP9.5 positive nerve fibres in tunica adventitia. Conclusions. Rich expression of TGFβ, VCAM, ICAM is characteristic for saphenous vein. A number of VEGF, MMP and TIMP positive cells found in saphenous vein wall indicates a presence of tissue remodelling and ischemia, while low number of HGF positive cells shows its lesser involvement in homeostasis regulation.
INTEGRATING FAITH AND LEARNING IN TEACHING ENGLISH AS A SECOND LANGUAGE: POSSIBILITIES IN GRAMMAR CLASSES

Nouns Nouns that refer to ideas, concept and other intangibles. But the fruit of the Spirit is love, joy, peace, longsuffering, kindness, goodness, faithfulness, gentleness, selfcontrol. Gal. 5:22 Why are "these things (which are abstract nouns)" called the fruit of the Spirit? Adjectives Adjectives modify nouns or pronouns. • The Lord, the compassionate and gracious God, slow to anger, abounding in love and faithfulness. " Exo. 34:6 • God is love. 1 Jn 4:8 • What are the characteristics of
Factors de risc biomecànics i estructurals en la Fasciosis Plantar en corredors adults. Revisió sistemàtica

Pregunta de revisio: Es la mesura de parametres estructurals i biomecanics una eina adequada per a identificar corredors adults amb risc de sofrir fasciosis plantar? Objectiu: Valorar l’existencia ferma de factors de risc biomecanics i/o estructurals relacionats amb la fasciosis plantar en corredors adults. Metodologia: Es va realitzar una cerca a PubMed, Scopus, PEDro i Cochrane Library d’articles publicats entre l’1 de gener de 2009 i el 31 de desembre de 2017, utilitzant els principals descriptors MeSH (Medical Subject Headings) “Fasciitis, Plantar” i “Running”. Posteriorment es va avaluar segons el sistema GRADE la qualitat metodologica dels articles que compliren els criteris de seleccio. Resultats: Es van incloure finalment 4 estudis amb una qualitat metodologica baixa que estudiaven un total de 195 individus. Conclusions: Sembla que l’augment de les carregues en la zona del retropeu a causa d’alteracions biomecaniques es troben estretament relacionades amb la FP. Aquest augment de les forces durant la carrera pot estar provocat per alteracions estructurals com ara la pronacio del retropeu o la forma de l’arc plantar. No obstant, els deficits metodologics dificulten una estructuracio ferma de l’evidencia cientifica en la cerca realitzada, fent necessaria la realitzacio d’estudis prospectius de qualitat.
Web personalization - a typology, instrument, and a test of a predictive model

Web Personalization – A Typology, Instrument, and a Test of a Predictive Model. (August 2007) Haiyan Fan, B.A., South China Normal University; M.S., University of Arizona Chairs of Advisory Committee: Dr. Marshall Scott Poole Dr. Joobin Choobineh In E-Commerce and mobile commerce, personalization has been recognized as an important element in customer relationship and Web strategies. However, there are wide differences in how this concept is defined, characterized, and measured in the literature. The extant personalization research is also limited by the lack of proper measurement instruments. While personalization has been recognized as a multi-dimensional construct, identifying those dimensions and operationalizing them in measurable terms has been a persistent and important research issue in MIS research. Furthermore, existing knowledge about user’s preference of different personalization features is sparse. In responding to these three limitations, this study aims to advance existing understanding in these three areas: First, the Web Personalization Measurement Instrument (WPMI) was developed based on the analysis of ideal types of personalization that are defined in terms of the motivation they supply for personalization and the goals and means of personalization. Reliability and construct validity of the instrument were established in this study. External validity and predictive validity issues were investigated by applying WPMI to a wide range of commercial websites. Second, this research examined the effect of Web personalization on positive user experience and its associated motivational states. Using commercial websites as stimuli for three different types of personalization strategies, this research conducted two independent studies and found supportive evidence for the positive influence of web personalization on user experience. In addition, we also identified distinct user motivational states salient to specific personalization strategies that are conducive to positive user experience. Third, this research examined the moderating effect of user values on the relationship between Web personalization and the
KEPATUHAN MEDIKASI PENDERITA DIABETES MELLITUS TIPE 2 BERDASARKAN TEORI HEALTH BELIEF MODEL (HBM) DI WILAYAH KERJA PUSKESMAS MULYOREJO SURABAYA

Introduction : Adherence play important role at therapeutic management of patients with type 2 Diabetes mellitus. The purpose this study was to identify and to analyse the factors associated with medication adherence. Methods : Design of the the study was descriptive analytic with cross-sectional approach. The population was patients with type 2 Diabetes mellitus in Puskesmas Mulyorejo Surabaya. Twenty eight as sample respondents were chosen by purposive sampling technique. The X variables in this study were age, sex, ethnicity, salary, knowledge, duration of illness, perceived susceptibility, perceived seriousness, perceived benefit, perceived barriers, self-efficacy, and family support. The Y variable was medication adherence of patients with type 2 Diabetes mellitus. Data were collected by using questionnaire and analyzed using chi square and spearman’s rho test with a degree of significance α<0.05. Result : Factors associated with medication adherence were sex, salary, knowledge, perceived seriousness, perceived benefit, self-efficacy, and family support. Factors not associated with mediacation adherence were age, ethnicity, duration of illness, perceived susceptibility, and perceived barriers. Perceived seriousness showed the strongest association with medication adherence (r=0.565). Discussion : Seven of twelve X variables were associated with perceived seriousness being the strongest association and five variables were not associated. It is expected that health care service develop the management of health service based on family and community to improve adherence at patients with type 2 Diabetes mellitus. Further research is suggested to enhance and develop the program to increase medication adherence.
ORIGINAL ARTICLE: A general dynamic theory of oceanic island biogeography

Aim MacArthur and Wilson’s dynamic equilibrium model of island biogeography provides a powerful framework for understanding the ecological processes acting on insular populations. However, their model is known to be less successful when applied to systems and processes operating on evolutionary and geological timescales. Here, we present a general dynamic model (GDM) of oceanic island biogeography that aims to provide a general explanation of biodiversity patterns through describing the relationships between fundamental biogeographical processes – speciation, immigration, extinction – through time and in relation to island ontogeny.
Erasmus MC Approaches to the i2b2 Challenge

Erasmus MC participated in the concept annotation and assertion classification subtasks of the fourth i2b2 challenge. For concept annotation, our approach consisted of tagging the clinical data with a variety of named entity recognizers and combining the resulting annotations into a final annotation set by means of a simple voting scheme. For assertion classification, we manually crafted decision rules using tools from a text engineering package. Our results show that a combined annotation system performs significantly better than any of the individual systems. The assertion classification system shows a good overall performance, but performs less well for "possible" and "conditional" assertions.
Energy Efficient Low Idle Listening Rate Medium Access Control for Body Sensor Network

Monitoring human movement using wireless sensory devices promises to revolutionize the delivery of healthcare services. Potentially, each action or disease can be discovered by collaborative processing of sensor data from multiple locations on the body. In spite of the revolutionary potential of BSN, power requirements have limited the commercialization. This paper presents an energy-e‐cient medium access control protocol for BSN applications. The proposed protocol is designed to transmit data in the manner of stratiflcation and asynchronous, which is based on heartbeat rhythm information and blood circulated theory. We experimentally compare the performance of the proposed protocol with other medium access control protocols. The results demonstrate that the protocol can reduce idle listening rate and save a signiflcant amount of energy of biosensors in BSN.
Pediatric Cancer Survivors at Risk for Stroke

Childhood survivors of brain tumors and leukemia are at particular risk for stroke later in life, according to research conducted through the University of Texas (UT) Southwestern Medical Center at Dallas.1 The medical center is one of 26 facilities involved in the Childhood Cancer Survivor Study (CCSS), a large, ongoing research investigation on the long-term effects of cancer and its treatment in the pediatric population.