Miracle-dz/UniFAR-FTUs huggingface dataset:
Ideology and Iconology

Is it possible to compose a history of images? It is obvious that history can be composed only from that which is intrinsically historical; history has an order of its own because it interprets and clarifies an order which already exists in the facts. But is there an order in the birth, multiplication, combination, dissolution and re-synthesis of images? Mannerism had discredited or demystified form with its pretense of reproducing an order which does not exist in reality. But is the world of existence, like the world of images, chaos or cosmos? Erwin Panofsky's' great merit consists in having understood that, in spite of its confused appearance, the world of images is an ordered world and that it is possible to do the history of art as the history of images. In order to do this, he had to begin, as indeed he did, with the demonstration that classical art, in spite of the deep-rooted theoretical certitude, is also an art of the image; its forms are nothing if not images to which one tries to attribute the consistency of concepts, with the sole result of demonstrating that even concepts are images and that the intellect is still another sector or segment of the image. Warburg and his circle in Hamburg, in which Panofsky first began to develop his ideas, had already demonstrated with patient philological research that the artistic culture of the Renaissance lives by the legacy of images received from classical antiquity. It lives, in other words, by his-
Learning Phrase Translation using Level of Detail Approach

We propose a simplified Level Of Detail (LOD) algorithm to learn phrase translation for statistical machine translation. In particular, LOD learns unknown phrase translations from parallel texts without linguistic knowledge. LOD uses an agglomerative method to attack the combinatorial explosion that results when generating candidate phrase translations. Although LOD was previously proposed by (Setiawan et al., 2005), we improve the original algorithm in two ways: simplifying the algorithm and using a simpler translation model. Experimental results show that our algorithm provides comparable performance while demonstrating a significant reduction in computation time.
New light on white matter.

Injury of central white matter is a major cause of functional disability in cerebrovascular disease. White matter is a target of hypoxic-ischemic injury throughout life, in clinical settings ranging from periventricular leukomalacia in the neonatal period, stroke and cardiac arrest in adults, to vascular dementia in the aging brain. The traditional view from animal studies is that gray matter is more vulnerable than white matter to ischemia.1 In part, this view may be an artifact of how ischemic brain injury has been studied. Most experimental work has used rodents, in which white matter constitutes only about 14% of total brain volume; in man, white matter is about 50% of brain volume.2 In fact, the metabolic rate of white matter is only modestly lower than that of gray matter,3 and recent animal studies suggest that white matter can be damaged even by brief ischemia.4 Moreover, clinical experience teaches that human ischemic stroke is almost never confined to gray matter. White matter is damaged by infarction in the territory of small vessels which perfuse centrum semiovale and deeper fiber pathways, and it is also damaged by occlusion of the large intracranial arteries which supply superficial gray and white matter together. Disruption of central conduction pathways may cause disruption of motor and sensory function, neurobehavioral syndromes,5 and cognitive impairment.6,7 Lacking neuronal cell bodies, dendrites, or synapses, white matter is unlikely to be injured by many of the mechanisms defined specifically in gray matter. Along with growing recognition of the importance of white matter ischemia in clinical disease, …
Ontology Similarity Measuring and Ontology Mapping Algorithms Based on Fused Lasso Signal

Ontology similarity calculation is important research topics in information retrieval and widely used in science and engineering. By analyzing the technology of fused lasso signal approximator, we propose the new algorithm for ontology similarity measure and ontology mapping. Via the ontology sparse vector learning, the ontology graph is mapped into a line consists of real numbers. The similarity between two concepts then can be measured by comparing the difference between their corresponding real numbers. The experiment results show that the proposed new algorithm has high accuracy and efficiency on ontology similarity calculation and ontology mapping.
Measuring Activity Performance of Continuing Care Residents Using the ActivPAL: An Exploratory Study.

Few studies have measured the activity patterns of continuing care residents using objective, uniaxial, accelerometers such as the activPAL. This exploratory study described the activity performance of continuing care residents and explored the correlation of activity performance with grip strength, falls and mobility. Data were gathered from 24 continuing care residents. Participants (82.3 ± 5.8 years of age), wore the activPAL an average of 12.60 hours per day (SD = 0.96) and were stepping for a median of 0.47 hours (25th and 75th percentiles = 0.31, 0.81) with a median step count of 1906 steps (25th and 75th percentiles = 1216, 3420). Participants were inactive (sitting/lying/standing) for a mean 11.99 hours (SD = 1.03). No statistically significant correlations were identified between activity performance (active time, inactive time or step count) and grip strength, falls or mobility. Ambulatory older adults in continuing care centres were more sedentary compared to community-dwelling older adults or older adults with cancer.
An Optimal Control Solved by Pontryagin's Minimum Principle Approach for a Fuel Cell/Supercapacitor Vehicle

A new real time optimal control based on Pontryagin's minimum principle approach is proposed in this article. The optimal control problem is formulated as an equivalent consumption minimization strategy (ECMS), which must be solved using the Pontryagin minimum principle (PMP). The proposed approach manages the power required and sources, depending on the unknown driving cycle. It is implemented by using the Matlab/Simulink software and its development tools in real time without any study in the off time or drive cycle and driving conditions. This approach is simplified on two major equations, the first calculates the costate variable in real time and the second deduces the optimal fuel cell power. Also, this approach has to satisfy the power requirement, reduce the hydrogen consumption, and maintain the super capacitor state of charge (SOC) bounded for the unknown driving cycles. The simulation results obtained show that these objectives are satisfied using this approach, even though these results are suboptimal in the global drive cycle due at the unknown drive final time.
An integrated tool planning and production planning problem for flexible manufacturing systems using genetic algorithm

This paper presents a novel concept of integrating tool planning and production planning problems in flexible manufacturing system. A mathematical objective function has been formulated that minimises the broad objectives of total costs comprising various parameters such as tool room capacity, tool budget, tool regrinding and procurement lead times, ordering, setup, holding and back-ordering costs of tools and parts. This paper explores the integrating notion by utilising the genetic-based search methodology. An illustrative example is taken into account for demonstrating the robustness of the proposed model. Genetic Algorithm (GA) has been implemented in the example under consideration and its performance is compared with Tabu Search (TS) and Simulated Annealing (SA). The extensive computations over the problems of varying complexities and dimensions prove the superiority of genetic algorithm. It has been observed that GA outperforms the standard algorithms (TS and SA) in the context of the underlying problem.
Comparison study of intraarticular and intravenous gadolinium-enhanced magnetic resonance imaging of cartilage in a canine model

Background: Magnetic resonance (MR) imaging and measurement of glycosaminoglycan (GAG) have potential for characterization of hyaline articular cartilage. Recently, some reports have demonstrated the potential of direct administration of contrast media for MR imaging of cartilage. Purpose: To prove the feasibility of intraarticular gadolinium-enhanced MR imaging of cartilage (iGEMRIC) and T1 relaxation mapping of the articular cartilage in vivo with intraarticular injection of Gd-DTPA2−. Material and Methods: Five healthy beagle dogs underwent MR imaging and T1 relaxation mapping of the knee joints of both hind legs. The delayed gadolinium-enhanced MR imaging of cartilage (dGEMRIC) and iGEMRIC techniques were interchanged with MR imaging. For dGEMRIC, a double routine dose of Gd-DTPA2− (0.2 mM/kg) was administered intravenously. For iGEMRIC, 2.5 and 1.25 mmol/l saline-diluted Gd-DTPA2− solutions were separately injected into the right and left knee joints, respectively, prior to MR imaging. Color-coded T1 maps of 20 femoral condyles were obtained from the dGEMRIC and iGEMRIC images. The signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and glycosaminoglycan (GAG) delineation of articular cartilage were compared between the dGEMRIC and iGEMRIC techniques. Results: The mean SNR was higher with dGEMRIC than with iGEMRIC, but the difference was not statistically significant (P = 0.174). The mean (±SD) CNR was higher with iGEMRIC (−11.6±3.4) than with dGEMRIC (−16.7±4.0; P = 0.000), although the absolute value of the CNR was higher with dGEMRIC. The layering and gradient distribution of GAG were more clearly visualized on the iGEMRIC images. The mean scores of GAG delineation with dGEMRIC and iGEMRIC were 0.7±0.6 and 2.2±1.7, respectively. The iGEMRIC method better visualized GAG distribution (P = 0.001). Conclusion: Although the SNR did not differ significantly between the iGEMRIC and dGEMRIC techniques, the color-coded T1 map produced with iGEMRIC allowed better cartilage evaluation. Thus, iGEMRIC exhibits the useful features of both MR arthrography and dGEMRIC, and provides a color-coded T1 map that is useful for diagnosing early articular cartilage damage.
Sharing Physician Notes Through an Electronic Portal is Associated With Improved Medication Adherence: Quasi-Experimental Study

Background In surveys, interviews, and focus groups, patients taking medications and offered Web portal access to their primary care physicians’ (PCPs) notes report improved adherence to their regimens. However, objective confirmation has yet to be reported. Objective To evaluate the association between patient Internet portal access to primary care physician visit notes and medication adherence. Methods This study is a retrospective comparative analysis at one site of the OpenNotes quasi-experimental trial. The setting includes primary care practices at the Geisinger Health System (GHS) in Danville, Pennsylvania. Participants include patients 18 years of age or older with electronic portal access, GHS primary care physicians, and Geisinger health plan insurance, and taking at least one antihypertensive or antihyperlipidemic agent from March 2009 to June 2011. Starting in March 2010, intervention patients were invited and reminded to read their PCPs' notes. Control patients also had Web portal access throughout, but their PCPs' notes were not available. From prescription claims, adherence was assessed by using the proportion of days covered (PDC). Patients with a PDC ≥. 80 were considered adherent and were compared across groups using generalized linear models. Results A total of 2147 patients (756 intervention participants, 35.21%; 1391 controls, 64.79%) were included in the analysis. Compared to those without access, patients invited to review notes were more adherent to antihypertensive medications—adherence rate 79.7% for intervention versus 75.3% for control group; adjusted risk ratio, 1.06 (95% CI 1.00-1.12). Adherence was similar among patient groups taking antihyperlipidemic agents—adherence rate 77.6% for intervention versus 77.3% for control group; adjusted risk ratio, 1.01 (95% CI 0.95-1.07). Conclusions Availability of notes following PCP visits was associated with improved adherence by patients prescribed antihypertensive, but not antihyperlipidemic, medications. As the use of fully transparent records spreads, patients invited to read their clinicians’ notes may modify their behaviors in clinically valuable ways.
Peer-to-Peer Product Sharing: Implications for Ownership, Usage, and Social Welfare in the Sharing Economy

We describe an equilibrium model of peer-to-peer product sharing, or collaborative consumption, where individuals with varying usage levels make decisions about whether or not to own a homogeneous product. Owners are able to generate income from renting their products to nonowners while nonowners are able to access these products through renting on an as-needed basis. We characterize equilibrium outcomes, including ownership and usage levels, consumer surplus, and social welfare. We compare each outcome in systems with and without collaborative consumption and examine the impact of various problem parameters. Our findings indicate that collaborative consumption can result in either lower or higher ownership and usage levels, with higher ownership and usage levels more likely when the cost of ownership is high. Our findings also indicate that consumers always benefit from collaborative consumption, with individuals who, in the absence of collaborative consumption, are indifferent between owning and not own.
Clinical trials utilizing stem cells for the treatment of cardiovascular disorders

In the past ten years, the concept of injecting stem and progenitor cells to assist with rebuilding damaged blood vessels and myocardial tissue after injury in the heart and peripheral vasculature has moved from bench to bedside. Non-invasive imaging can not only provide a means to assess cardiac repair and, thereby, cellular therapy efficacy but also a means to confirm cell delivery and engraftment after administration. In this first of a two-part review, we will review the different types of cellular labeling techniques and the application of these techniques in cardiovascular magnetic resonance and ultrasound. In addition, we provide a synopsis of the cardiac cellular clinical trials that have been performed to-date.
A practical approach to job-shop scheduling problems

The use of Lagrangian relaxation to schedule job shops, which include multiple machine types, generic precedence constraints, and simple routing considerations, is explored. Using an augmented Lagrangian formulation, the scheduling problem is decomposed into operation-level subproblems for the selection of operation beginning times and machine types, with given multipliers and penalty coefficients. The multipliers and penalty coefficients are then updated at the higher level. The solution forms the basis of a list-scheduling algorithm that generates a feasible schedule. A procedure is also developed to evaluate the quality of this feasible schedule by generating a lower bound on the optimal cost. Numerical examples are taken from a representative industrial job shop. High-quality schedules are efficiently generated every other day over a three-week period, with costs generally within 4% of their respective lower bounds. The methodology compares favorably with knowledge-based scheduling. >
Rhenium-188(Sn)HEDP for treatment of osseous metastases.

UNLABELLED Rhenium-188 (tin) hydroxyethylidine diphosphonate [188Re(Sn)HEDP] is a new radiopharmaceutical that localizes in skeletal metastases and emits beta particles that may be therapeutically beneficial. METHODS It was evaluated by in vitro and in vivo testing in the laboratory, in animals and in humans using 188Re from a variety of sources. It may be produced by a desk-top method developed previously for 186Re(Sn)HEDP using 188Re produced through neutron irradiation of either enriched 187Re or naturally occurring rhenium targets or the use of a 188W/188Re generator. RESULTS So long as the mass of rhenium in the 188Re-perrhenate to be processed into 188Re(Sn)HEDP is at least 100 microg, satisfactory radiochemical yields and purity may be obtained by all methods. The 188Re(Sn)HEDP has biodistribution and radiation dosimetry characteristics that are similar to those noted previously for 186Re(Sn)HEDP and appears to result in similar benefits and toxicities in patients with skeletal metastases. External radiation exposure monitoring indicates that, only 4 hr after a therapeutic administration of 1110 MBq (30 mCi) of 188Re(Sn)HEDP, average exposure rates at 1 meter from the patient would be only 0.5 mR/hr. CONCLUSION Same-day, on-demand, outpatient therapy of disseminated skeletal metastases appears to be feasible with 188Re(Sn)HEDP.
Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells

The maintenance of immune tolerance to apoptotic cells (AC) within an inflammatory milieu is vital to prevent autoimmunity. To investigate this, we administered syngeneic AC i.v. into mice carrying a cohort of ovalbumin (OVA)-specific transgenic T cells (DO11.10) along with OVA peptide and complete Freund's adjuvant, observing a dramatic increase in OVA-specific IL-10 secretion. Activated splenic B cells responded directly to AC, increasing secretion of IL-10, and this programming by AC was key to inducing T cell-derived IL-10. We went on to ask whether AC are able to modulate the course of autoimmune-mediated, chronic inflammation. AC given up to 1 month before the clinical onset of collagen-induced arthritis protected mice from severe joint inflammation and bone destruction. Antigen-specific CD4+ T cells again secreted significantly more IL-10, associated with a reduced titer of pathogenic anti-collagen II antibodies. Inhibition of IL-10 in vivo reversed the beneficial effects of AC. Passive transfer of B cells from AC-treated mice provided significant protection from arthritis. These data demonstrate that AC exert a profound influence on an adaptive immune response through the generation of CD19+ regulatory B cells, which in turn are able to influence the cytokine profile of antigen-specific effector T cells.
Radiological use of fast protons.

Except for electrons, the particles which have been accelerated to high energies by machines such as cyclotrons or Van de Graaff generators have not been directly used therapeutically. Rather, the neutrons, gamma rays, or artificial radioactivities produced in various reactions of the primary particles have been applied to medical problems. This has, in large part, been due to the very short penetration in tissue of protons, deuterons, and alpha particles from present accelerators. Higher-energy machines are now under construction, however, and the ions from them will in general be energetic enough to have a range in tissue comparable to body dimensions. It must have occurred to many people that the particles themselves now become of considerable therapeutic interest. The object of this paper is to acquaint medical and biological workers with some of the physical properties and possibilities of such rays. To be as simple as possible, let us consider only high-energy protons: later we can generalize to oth.
Renal denervation using catheter-based radiofrequency ablation with temperature control: renovascular safety profile and underlying mechanisms in a hypertensive canine model

Abstract Objective: Renal denervation is a novel method for hypertension treatment. In this study, we aimed to investigate the safety and efficacy of radiofrequency ablation (RFA) at ablation temperatures of 45 °C or 50 °C and its possible mechanisms. Methods: A hypertensive canine model was established by abdominal aortic constriction in 20 healthy hybrid dogs. These dogs were then randomly assigned to the treatment and the control groups, with dogs in the treatment group further randomly assigned to receive RFA at ablation temperatures of 45 °C or 50 °C. In the treatment group, RFA was performed at 1 month after modeling; renal angiography was performed at 2 months after ablation. The arterial vessels of the dogs were examined histologically with hematoxylin and eosin staining. Changes in blood pressure in the foreleg and whole-body norepinephrine spillover rate were also assessed. Results: No arterial stenosis, dissection, thrombosis or other abnormalities were detected in the treated vessels by renal angiography, yet histology results showed minimal to mild renal arterial injury. Renal denervation resulted in a marked decrease in the whole-body norepinephrine spillover rate (p < 0.05) in addition to significantly reducing blood pressure (p < 0.05), with no significant differences detected between the 45 °C and 50 °C subgroups for both (p > 0.05). Conclusion: Renal denervation can be performed without acute major adverse events, using catheter-based RFA with temperature control. The procedure was feasible in reducing blood pressure by at least partially inhibiting sympathetic drive and systemic sympathetic outflow.
Tissue levels of tumor necrosis factor-alpha correlates with grade of inflammation in untreated ulcerative colitis

Objective. The immune characterization of ulcerative colitis (UC) has been unclear and controversial. One possible explanation for the discrepancies between earlier cytokine studies in UC may be the fact that the patients included were on immunosuppressive therapy. Thus, the aim of this study was to determine the tumor necrosis factor-alpha (TNF-α) level and TH1/TH2 cytokine expression (mRNA) profile in patients with untreated UC. Material and methods. Forty-four untreated UC patients, 10 untreated Crohn's disease (CD) patients and 28 healthy controls were included in the study. Colon biopsies were processed for quantitative measurements of TNF-α, interleukin (IL)-10, IL-18, IL-4 and interferon-gamma (IFN-γ) mRNA using real-time polymerase chain reaction (PCR). TNF-α expression in T-cell lymphocytes (CD3) and macrophages (CD68) were further characterized by immunohistochemistry (IHC). Results. Compared with the level in normal controls, the TNF-α mRNA level in UC patients was clearly increased, especially in patients with moderate to severe disease. The levels of TNF-α mRNA increased in proportion to the UC Disease Activity Index (UCDAI) score in UC patients. Differences were also observed between UC and controls for IFN-γ IL-18, IL-4 and IL-10. Only minor quantitative differences in cytokines were observed between UC and CD, and they were more or less similar when comparing moderate to severe UC and CD. CD3+ lymphocytes and macrophages in lamina propria from CD and UC lesions showed increased intracellular staining of TNF-α. Conclusions. TNF-α is highly expressed in UC and correlates to the grade of inflammation. The sources of TNF-α were observed both in CD3+ lymphocytes and in macrophages. Cytokine expression (mRNA) profiles seem to be similar in patients with moderate to severe UC and CD.