Miracle-dz/UniFAR-FTUs huggingface dataset:
Neurobehavioral Characteristics of Adolescents with Behavioral Dysregulation Disorder

Background There is growing recognition that violence and other forms of conduct problems increase during adolescence. The exact relationship between biological, psychological, and social variables has not been defined yet. Objectives To analyze whether Intelligence Quotients (IQS), neurological history, child behavioral problems, executive functions, and soft neurological signs (SNS) can differentiate between undisciplined and unreliable adolescents (Behavioral Dysregulation Disorder subjects, BDD) and normal controls. Method Twenty-five 13 to 16-year-olds, adolescents with BDD and 25 matched controls were used in this study. WISC-R, executive function assessment, neurological history, child behavioral problems, and SNS scores were analyzed using a Multivariate Analysis of Variance (MANOVA). A Multiple Regression Stepwise with Criteria Probability of F Analysis was used for predicting criteria variable variance-Results WISC-R Verbal 1Q (VIQ), Information, Similarities, and Vocabulary subtests presented statistically significant differences between BDD and controls (p <. 001). No Performance IQ (P1Q) variables established significant differences between both groups. Executive function scores did not detect significant differences between groups either. Prenatal, neonatal, and neurological history scores were similar between both groups. Two child behavioral problem variables were significantly different, with higher scores in BDD group: use of weapons and drug-use (p <. 05). A Multiple Regression Stepwise (Criteria Probability of F <. 05) model, entering the predictive variables in each domain
Persistent current of a Hubbard ring threaded with a magnetic flux.

The persistent current in microscopic and mesoscopic Hubbard rings threaded with magnetic flux is studied as a function of the flux and the Coulomb repulsion parameter U. For microscopic rings having very large U, we find that as the flux is increased by one quantum, a magnon hole traverses the magnon sea, generating a periodicity of 1/N c in the persistent current, but with no changes in the overall spin magnetization, in contrast to the earlier suggestion of Kusmartsev. For non-half-filled mesoscopic rings, we use methods developed by Woynarovich for the zero-flux case to build a rather complete picture of the variation of persistent current with magnetix flux
Immunoglobulin G1 Antibody Response toHelicobacter pylori Heat Shock Protein 60 Is Closely Associated with Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

ABSTRACT Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is related to Helicobacter pylori infection. Specifically, it has been pointed out that pathogenesis of MALT lymphoma involves the 60-kDa heat shock protein (hsp60). To investigate humoral immune responses to the H. pylori hsp60 in patients with gastroduodenal diseases and patients with MALT lymphoma, the hsp60 ofH. pylori was expressed with a glutathioneS-transferase fusion protein and was purified (recombinant hsp60). Sera were obtained from H. pylori-positive patients with gastroduodenal diseases (MALT lymphoma, n = 13; gastric ulcer, n = 20; duodenal ulcer, n = 20; gastritis,n = 20) and from H. pylori-negative healthy volunteers (n = 9). Sera from patients with MALT lymphoma were also obtained at two times: before and after eradication therapy. Antibodies to hsp60 and H. pylori were assessed by enzyme-linked immunosorbent assay. The levels of immunoglobulin G (IgG) antibodies to the hsp60 of H. pylori-positive patients with gastroduodenal diseases were significantly elevated compared to those in the controls. The levels of IgG1 antibodies to hsp60 were elevated and correlated with the levels of anti-H. pylori antibodies in patients with MALT lymphoma. Humarol immunity against hsp60 may be important and relevant to gastroduodenal diseases induced by H. pylori infection.
Risk of hospitalization for heart failure in patients with type 2 diabetes newly treated with DPP-4 inhibitors or other oral glucose-lowering medications: a retrospective registry study on 127,555 patients from the Nationwide OsMed Health-DB Database.

AIMS Oral glucose-lowering medications are associated with excess risk of heart failure (HF). Given the absence of comparative data among drug classes, we performed a retrospective study in 32 Health Services of 16 Italian regions accounting for a population of 18 million individuals, to assess the association between HF risk and use of sulphonylureas, DPP-4i, and glitazones. METHODS AND RESULTS We extracted data on patients with type 2 diabetes who initiated treatment with DPP-4i, thiazolidinediones, or sulphonylureas alone or in combination with metformin during an accrual time of 2 years. The endpoint was hospitalization for HF (HHF) occurring after the first 6 months of therapy, and the observation was extended for up to 4 years. A total of 127 555 patients were included, of whom 14.3% were on DPP-4i, 72.5% on sulphonylurea, 13.2% on thiazolidinediones, with average 70.7% being on metformin as combination therapy. Patients in the three groups differed significantly for baseline characteristics: age, sex, Charlson index, concurrent medications, and previous cardiovascular events. During an average 2.6-year follow-up, after adjusting for measured confounders, use of DPP-4i was associated with a reduced risk of HHF compared with sulphonylureas [hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.62-0.97; P = 0.026]. After propensity matching, the analysis was restricted to 39 465 patients, and the use of DPP-4i was still associated with a lower risk of HHF (HR 0.70; 95% CI 0.52-0.94; P = 0.018). CONCLUSION In a very large observational study, the use of DPP-4i was associated with a reduced risk of HHF when compared with sulphonylureas.
Treatment of gonorrhea: comparison of cefotaxime and penicillin

Ninety-seven patients with 118 sites infected with Neisseria gonorrhoeae were treated with a single dose of either procaine penicillin G (4.8 x 10(6) U) or cefotoxime (1.0 g) intramuscularly. Only the penicillin group took 1 g of probenecid orally. The numbers of infected sites in each treatment group were as follows: penicillin-urethra, 37; rectum, 9; cervix, 8; and pharynx, 4; cefotaxime-urethra, 42; rectum, 9; cervix, 5; and pharynx, 4. The cure rates in each treatment group were 100%. No adverse reactions were noted in either group. beta-Lactamase-positive N. gonorrhoeae strains were not found. Ninety-five percent of clinical isolates were inhibited by less than or equal to 0.007 micrograms of cefotaxime and less than or equal to 0.25 micrograms of penicillin per ml. In this study cefotaxime was as effective as procaine penicillin in the treatment of uncomplicated gonorrhea.
Effects of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease: a prospective controlled study

Background Freezing of gait (FOG) is a debilitating gait disorder in Parkinson's disease (PD) with partial responsiveness to dopaminergic medication. To date, notions about the effects of subthalamic deep brain stimulation (STN-DBS) on FOG remain controversial. Objectives To compare the effects of bilateral STN-DBS and continued best medical treatment (BMT) on FOG occurrence, FOG severity and clinical outcomes in PD patients at 6 and 12 months follow-up. Methods In this prospective, controlled study, 41 PD patients with at least 5 years disease duration participated. Twenty-four subjects (20 with FOG) were treated with STN-DBS and seventeen (15 with FOG) continued BMT. The primary outcome was the New Freezing of Gait Questionnaire (NFOGQ) at 6 months postsurgery. Other outcomes were the NFOGQ at 12 months and clinical outcomes (Unified Parkinson's Disease Rating Scale III (UPDRS III), timed gait, falls and quality of life) at both time points. Results STN-DBS increased the likelihood to convert from being a freezer to a non-freezer at 6 and 12 months follow-up (relative risk reduction=0.4). However, 45% of baseline freezers still experienced FOG 6 and 12 months postsurgery although with reduced severity. Three baseline non-freezers (1/2 BMT-treated, 2/4 STN-DBS-treated) developed FOG during follow-up. STN-DBS-induced benefits on FOG were mostly mediated by baseline levodopa equivalent dose, altered medication-intake and reduced motor fluctuations. Conclusions In contrast to continued BMT, STN-DBS reduced FOG occurrence and severity at 6 months postsurgery with largely sustained effects at 12 months follow-up. Longer follow-up periods are needed to test whether FOG improvements after STN-DBS persist with disease progression.
Islet cell autoantigens in insulin-dependent diabetes.

A burgeoning number of antigenic targets of the islet cell autoimmunity in IDD have been identified, and more can be anticipated through improved methods for their identification. The challenge for those investigating the pathogenesis of IDD will be to assign the relative importance of these antigens to the development of the disease, and to resolve whether there is a dominant primary immunologic event that is followed by a series of secondary immunizations to a variety of normally sequestered islet cell antigens in the sequence of pathogenic events that culminate in IDD. One interesting observation that may have potential pathogenic implications is the observation that of all islet cell autoantigens described, only two (i.e., 64 kD/GAD, 38 kD) are reactive in their native configurations, implying that recognition of conformational epitopes is most important. This property argues for primary immunizing agents rather than secondary ones after release of denatured antigens and antigenic recognition through their epitopes. Given the complex and multiple physiological functions of islet cells and the continuous variation in their activity, it is reasonable to speculate that the speed of the progression to IDD could vary between individuals with respect to their insulin needs and the relative activities of their islets. Activated islets may express autoantigens that have only limited expression in quiescent islets. The often times striking variation in the severity of insulitis seen in different islets of a single pancreas may be explained by the level of activity of individual islets. Furthermore, disparity in HLA-DR/DQ associations with disease may involve differences in the immunological recognition of autoantigens. Whereas there is still much to learn, it is clear that disease predictability and disease intervention studies have been enhanced through the identification of the islet cell autoantigens in IDD.
Corona Discharge With Electrospraying System for Phenol Removal From Water

In the present work, a pulsed pin-to-plate corona reactor has been used for phenol removal from water. The main advantage of the present reactor is the presence of electrospraying of water drops at the tip of the discharge pin simultaneously with corona streamer. Electrospraying increases the treated surface area and therefore increases the efficiency of the water treatment. Also, the microdroplets of the sprayed water pass through the different regions of the discharge streamer and hence are in contact with the different plasma species which enhances the treatment process. The physical and chemical reactions of the plasma species affecting the phenol treatment have been discussed. Effects of the applied voltage, the running number of re-treatments, the phenol concentration, and the type of the working gas on the treatment process have been studied. At optimum conditions of the reactor, a percentage removal of phenol of 99.5% has been achieved with an efficiency of 2.5 g/kWh.
GABAergic modulation of neocortical long‐term potentiation in the freely moving rat

Although the neocortex has generally been considered resistant to the induction of long‐term potentiation (LTP), we have recently shown that LTP can be reliably induced in the freely moving rat provided that the stimulation sessions are spaced and repeated. Here, we report that the induction of LTP in this preparation can be modulated by both GABAergic agonism and antagonism. The delivery of stimulation trains in the presence of the GABAA agonist diazepam blocked the induction of neocortical LTP, while the GABAA antagonist picrotoxin slowed the development of potentiation. When animals that had previously received high‐frequency stimulation combined with diazepam were repotentiated, they showed greater resistance to LTP induction than animals that had received diazepam alone. These data suggest that the inhibitory circuits themselves may have potentiated. The demonstration that diazepam blocks neocortical LTP provides further support for the notion that LTP plays a role in memory formation. Synapse 35:120–128, 2000. © 2000 Wiley‐Liss, Inc.
Soliton robustness to the polarization-mode dispersion in optical fibers

The influences of chromatic dispersion, coupling length, and soliton energy on the soliton robustness to polarization-mode dispersion (PMD) are investigated numerically. We find that both chromatic dispersion and soliton energy have significant effects on the soliton robustness to PMD, and by optimizing chromatic dispersion and soliton energy, soliton pulse broadening can be depressed to within 10% even when the differential group delay is about twice the input pulse width. In addition, a recent experimental result on soliton robustness is numerically verified.
Highly Air‐Stable Phosphorus‐Doped n‐Type Graphene Field‐Effect Transistors

Phosphorus-doped double-layered graphene field-effect transistors (PDGFETs) show much stronger air-stable n-type behavior than nitrogen-doped double-layered graphene FETs (NDGFETs), even under an oxygen atmosphere, due to strong nucleophilicity, which may lead to real applications for air-stable n-type graphene channels.
The natural history of Stevens–Johnson syndrome: patterns of chronic ocular disease and the role of systemic immunosuppressive therapy

Objective: To characterize patterns of chronic ocular disease in patients with Stevens–Johnson syndrome (SJS) and its variant toxic epidermal necrolysis (TEN), and to describe their response to treatment. Methods: Retrospective case series. A review of hospital records of 30 patients (60 eyes) with ocular manifestations of SJS or TEN was carried out. The principal outcome measure was to identify and classify the patterns of chronic ocular disease in SJS and TEN. The secondary outcome measure was the response to treatment. Results: Patterns of chronic ocular disease observed after the acute episode included: mild/moderate SJS, severe SJS, ocular surface failure (SJS-OSF), recurrent episodic inflammation (SJS-RI), scleritis (SJS-S) and progressive conjunctival cicatrisation resembling mucous membrane pemphigoid (SJS-MMP). The median follow-up was 5 years (range 0–29). 19 patients (29 eyes (48%)) developed SJS-OSF, SJS-RI, SJS-S or SJS-MMP during follow-up. SJS-OSF was present in 12 patients (18 eyes (30%)). In 5 patients (eight eyes) this developed 1 year after the acute illness, without any further inflammatory episodes; it was associated with SJS-RI in 1 patient (2 eyes), with SJS-RI and SJS-S in 1 patient (1 eye), with SJS-S in 1 patient (1 eye) and with SJS-MMP in 4 patients (6 eyes). Episodes of SJS-RI occurred in 4 patients (7 eyes (12%)). The median time from acute disease to the first episode of SJS-RI was 8.5 years (range 5–63). SJS-S developed in 2 patients (4 eyes (7%)), of which 2 eyes subsequently developed SJS-OSF. SJS-MMP developed in 5 patients (10 eyes (16.6%)). The median duration from the acute stage to the diagnosis of SJS-MMP was 2 years (range 1–14). Immunosuppressive therapy successfully controlled inflammation in 10/10 patients with SJS-MMP, SJS-RI or SJS-S. Conclusion: Ocular disease in SJS/TEN is not limited solely to the sequelae of the acute phase illness. Patients and physicians need to know that ocular disease progression, due to surface failure and/or acute inflammatory conditions, may occur at variable periods following the acute disease episode. Recognition of this, and prompt access to specialist services, may optimise management of these uncommon patterns of disease in SJS.
Glycosylation profiling in clinical proteomics: heading for glycan biomarkers

‘A broadening of the analytical repertoire to analyze (parts of) the glycome in addition to the proteome seems promising and is expected to result in a group of carbohydrate-based biomarkers. ’ Manfred Wuhrer Leiden University Medical Center, Biomolecular Mass Spectrometry Unit, Department of Parasitology, PO Box 9600, 2300 RC Leiden, The Netherlands Tel. : +31 715 255 079 Fax: +31 715 266 907 m.wuhrer@lumc.nl Expert Rev. Proteomics 4(2), 135–136 (2007)
Dysfunctional schemas and cognitive distortions in psychopathology: a test of the specificity hypothesis.

This study aimed at testing whether there were different types of dysfunctional schemas and cognitive distortions that could help to differentiate three emotional/behavioural problems, i.e., anxiety, depression, and aggression, from each other. Five hundred and eighty-one Chinese adolescents from five mainstream high schools in Hong Kong were recruited and completed several self-report questionnaires. Bivariate correlation showed an indiscriminate pattern of association between dysfunctional schemas, cognitive distortions, and the three emotional/behavioural problems. However, when the effects of the confounding correlated emotional/behavioural problems were controlled in regression analysis, different problems did show some specific association with different types of dysfunctional schemas and/or cognitive distortions. Despite some inconsistency, these findings generally supported a specificity hypothesis. Cognitive variables were thus not only relevant in understanding psychopathology, but their different patterns of association with anxiety, depression, and aggression also supported the separability of these three emotional/behavioural problems, despite their significant correlation.
The effect of submaximal exercise on recovery hemodynamics and thermoregulation in men and women.

Five women and 5 men were studied to examine the effects of submaximal exercise on thermoregulatory and hemodynamic variables during recovery in two environments: (a) control (C), 22 degrees C, 33% rh; and (b) hot humid (H), 32 degrees C. The participants exercised on a cycle ergometer at 60% of peak oxygen consumption for 35 min prior to 90 min of seated recovery. Sessions were identical, except for environment. Variables evaluated (p < .05) were: core temperature (TR), mean skin temperature (Ts), sweat rate (SR), heart rate (HR), stroke index (SI), cardiac index (CI), forearm blood flow (FBF), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Men and women exhibited similar patterns of TR, Ts, and SR in both environments. Ts and SR (collapsed means for gender) were higher in the H than in the C. DBP was higher in men than in women throughout recovery in both environments. With combined means for gender, HR was higher in the H than in the C. CI, SI, FBF, and SBP were similar in both environments and returned to baseline within 15 min into recovery. These data suggest that heat dissipation during extended recovery was accomplished with similar contributions of cutaneous vasodilation and sweating in M and F. Furthermore, the moderate exercise level did not influence hemodynamics beyond 15 min of recovery in either environment.
Missing links : the genetic architecture of flower and floral diversification

Variations in floral architecture are evolutionarily and economically important, affecting features such as pollination, predation and seed dispersal. However, in spite of the central role of flowers in plant reproduction, agriculture and horticulture, the processes responsible for the origin and subsequent evolution of the flower remain fundamental problems in plant biology. Major questions include the following. •How did flowers become bisexual, given that male and female reproductive organs are in separate structures in all extant gymnosperms? •How did the major organs (sepals, petals, stamens and carpels) originate? What genes control the number, arrangement and fusion of floral organs? •Which effector genes generate the characteristic features of these major organs? •Which genes control floral initiation and development throughout the angiosperms, especially in the most basal lineages, and how do they compare with those in model organisms? •How much of the developmental machinery is common to most lineages and how much is peculiar to restricted groups of angiosperms?
Highly Compressible and All‐Solid‐State Supercapacitors Based on Nanostructured Composite Sponge

Based on polyaniline-single-walled carbon nanotubes -sponge electrodes, highly compressible all-solid-state supercapacitors are prepared with an integrated configuration using a poly(vinyl alcohol) (PVA)/H2 SO4 gel as the electrolyte. The unique configuration enables the resultant supercapacitors to be compressed as an integrated unit arbitrarily during 60% compressible strain. Furthermore, the performance of the resultant supercapacitors is nearly unchanged even under 60% compressible strain.
Obesity, airflow limitation, and respiratory symptoms: does it take three to tango?

resolution and prevent serious sequelae. The EPOS 2012 guidelines have stricter recommendations and stratify treatment based on case categorisation; 1) common cold/acute viral rhinosinusitis 2) acute post-viral rhinosinusitis (moderate symptoms – recommend intranasal steroids but no antibiotics), and 3) acute bacterial rhinosinusitis (severe symptoms – antibiotics and intranasal steroids recommended). For antibiotic rates to decrease, we need to continue to educate medical providers. In addition, there must be changes in societal expectations, since patient demand is a strong barrier to limiting prescription rates. Subjects in this study by Stjärne and colleagues reported poor QoL. They noted high rates of pain/discomfort and limitation to usual activities, so understandably they desired symptom relief. But antibiotics are not always beneficial and can cause harm. Physicians should be aided by national programmes to educate both healthcare providers and the general population. This is a timely message. The American Academy of Allergy, Asthma, and Immunology has recently updated its teaching slides on both acute and chronic rhinosinusitis. This was an international effort involving experts from around the world from the fields of allergy and immunology, otolaryngology, and radiology. These new teaching slides provide a review of the epidemiology, diagnosis and management of rhinosinusitis, and can be accessed without charge at: http://education.aaaai. org/courses. Additional teaching slides are available on a wide variety of respiratory conditions, providing Continuing Medical Education (CME) credits for trainees, primary care physicians and specialists.
Identifying and Defining the Dimensions of Community Capacity to Provide a Basis for Measurement

Although community capacity is a central concern of community development experts, the concept requires clarification. Because of the potential importance of community capacity to health promotion, the Division of Chronic Disease Control and Community Intervention, Centers for Disease Control and Prevention (CDC), convened a symposium in December 1995 with the hope that a consensus might emerge regarding the dimensions that are integral to community capacity. This article describes the dimensions that the symposium participants suggested as central to the construct, including participation and leadership, skills, resources, social and interorganizational networks, sense of community, understanding of community history, community power, community values, and critical reflection. The dimensions are not exhaustive but may serve as a point of departure to extend and refine the construct and to operationalize ways to assess capacity in communities.