Miracle-dz/UniFAR-FTUs huggingface dataset:
Inflammation‐induced overexpression of microRNA‐223‐3p regulates odontoblastic differentiation of human dental pulp stem cells by targeting SMAD3

AIM To profile miRNA expression between inflamed and healthy human dental pulp tissues and to investigate how the upregulation of miR-223-3p in the inflamed pulp tissue regulates odontoblast differentiation and regeneration. METHODOLOGY Microarray analysis was used to identify differences in miRNA expression patterns between healthy and inflamed pulp tissue. The results were validated using quantitative real-time PCR. To determine the effect of miR-223-3p on odontoblast differentiation, miR-223-3p was overexpressed in human dental pulp stem cells (DPSCs), which were cultured in mineralizing induction medium (to induce odontoblast differentiation). To identify the target genes of miR-223-3p, an SABiosciences Human Osteogenesis PCR Array, combined with bioinformatics, was used. Furthermore, a dual-luciferase reporter assay and a small interfering RNA (siRNA) experiment were used to confirm the relationship between miR-223-3p and its target gene. Statistical analysis was performed using the Student's t-test or one-way analysis of variance (anova); P < 0.05 was considered statistically significant. RESULTS Seventy-nine miRNAs were significantly differentially expressed (fold change >2.0; P < 0.05) between the two tissues. In particular, miR-223-3p was markedly upregulated in inflamed dental pulp. Overexpression of miR-223-3p in DPSCs significantly increased the protein levels of dentine sialophosphoprotein (DSPP) and dentine matrix protein 1 (DMP-1) (P < 0.05). However, the SMAD family member 3 (SMAD3) protein level was significantly lower than in control DPSCs (P < 0.05). Bioinformatics and the dual-luciferase assay reporter assay indicated that Smad3 was a potential target of miR-223-3p. Knockdown of Smad3 in DPSCs subjected to mineralization induction resulted in detection of DSPP and DMP-1 earlier than in control DPSCs, and it increased the protein level of alkaline phosphatase (ALP), thereby promoting odontoblast differentiation. CONCLUSIONS miR-223-3p is implicated in the regulation of odontoblast differentiation, which may be involved in the process of pulpitis repair.
Stabilization of Colloidal Crystals Engineered with DNA

A postsynthetic method for stabilizing colloidal crystals programmed from DNA is developed. The method relies on Ag+ ions to stabilize the particle‐connecting DNA duplexes within the crystal lattice, essentially transforming them from loosely bound structures to ones with very strong interparticle links. Such crystals do not dissociate as a function of temperature like normal DNA or DNA‐interconnected superlattices, and they can be moved from water to organic media or the solid state, and stay intact. The Ag+‐stabilization of the DNA bonds is accompanied by a nondestructive ≈25% contraction of the lattice, and both the stabilization and contraction are reversible with the chemical extraction of the Ag+ ions, by AgCl precipitation with NaCl. This synthetic tool is important, since it allows scientists and engineers to study such crystals in environments that are incompatible with structures made by conventional DNA programmable methods and without the influence of a matrix such as silica.
SECY APP: Self Configuration and Easy Management for Software Defined Smart Homes

In this paper we address configuration and management issues of smart homes. Current platforms requires the user to deal with several management inconvenience problems, such as increasing devices, operating between devices, and using new devices. From a user perspective, system configuration and management are major issues: ordinary consumers want to use systems performing minimal configuration. To address this issue, we propose a platform, composed of a web application and Software Defined Network (SDN). While the user interacts with an easy-to-use interface on a smart device, the app automatically generates and installs SDN rules. Our platform, besides facilitating configuration and management, results more efficient --- up to 4 times faster --- and reliable --- able to operate even in case of no connection with the cloud --- than current solutions.
The burden of apathy for caregivers of patients with amyotrophic lateral sclerosis

Abstract Objectives: Apathy is the most common behavioral symptom of amyotrophic lateral sclerosis (ALS). Despite its known impact on caregiver wellbeing, apathy is typically considered a unitary construct making assessment and targeting treatment problematic. The aim of this study was to explore the relationship between caregiver burden and the behavioral, cognitive, and emotional symptoms of apathy in ALS. Methods: Fifty-one ALS patient-caregiver dyads from an ALS/frontotemporal dementia Clinic were assessed with the Apathy Evaluation Scale which measured the cognitive, behavioral, emotional, and nonspecific symptoms of apathy as well as the Zarit Burden Interview, a measure of perceived burden among caregivers of cognitively impaired older adults. The relationship between apathy and caregiver burden were analyzed using univariate and multivariate methods. Results: Apathy was identified in 18% of ALS patients. Greater behavioral (p = 0.011) and nonspecific (p = 0.010) symptoms of apathy exhibited by patients were reported by caregivers with higher levels of burden compared to caregivers with lower levels of burden. Of the cognitive, behavioral, emotional, and nonspecific symptoms of apathy, only the behavioral symptoms explained a significant amount of variance in caregiver burden (p = 0.031). Conclusions: Apathy, specifically the behavioral symptoms of apathy was associated with higher burden of care among ALS caregivers, highlighting the importance of multidimensional assessment of apathy and provision of behavior management support as part of ALS care.
Improvement in Classification of Tactile Event-Related Potentials using Random-Interval Tasks∗

The classification accuracy of an event-related potential (ERP) induced by a tactile stimulus is investigated to create a brain-computer interface (BCI). Mechanical tactile stimuli were applied to the left and right index fingers using two piezo actuator probes that were used as a Braille display for the visually impaired. In an experiment, two-class classification was investigated using three kinds of tactile stimulus pattern. The subjects were instructed to pay attention to unusual target stimuli while avoiding other frequent nontarget stimuli. The extracted features were classified using stepwise linear discriminant analysis. As a result, high accuracy was obtained by the task of random intervals compared with the task of constant intervals. It was suggested that the accuracy of the BCI using tactile stimuli is influenced by the concentration on the task.
Hidden Markov Model for Masquerade Detection Based on Sequence Alignment

A masquerade attack, in which an attacker impersonates a legitimate user to utilize the user's privileges, can be triggered either by someone within the organization or by an outsider. We propose the sequence alignment based hidden Markov model (SA-HMM) approach, where we incorporate the benefits of both the sequence alignment and continuous hidden Markov model (HMM). The sequence alignment module for the proposed algorithm allows the algorithm to tolerate variations in user activity sequence. The HMM module takes the positional information between the observations of users into account. The proposed approach achieves a high hit ratio of 94.1% outperforming existing masquerade detection approaches.
The efficacy and safety of different long-acting β2-agonists combined with inhaled glucocorticoid regimens in patients with asthma: a network meta-analysis

Abstract Objective: To determine the efficacy and safety of current maintenance therapies consisting of different regimens of long-acting β2-agonists (LABA) with inhaled corticosteroids (ICS) in patients with asthma. Methods: A network meta-analysis (NMA) was conducted after a comprehensive search for relevant studies in the PubMed, Cochrane Library, and Embase databases up to January 1, 2017. Randomized clinical trials comparing LABA combined with ICS in patients with asthma were selected. Results: Seventeen trials were included in the analysis, comprising 10,961 patients and seven treatment regimens. Our NMA revealed that there were no statistically significant differences between agents regarding the frequency of moderate or severe exacerbations. For adverse effects, there were no significant differences between the included studies. Moreover, six of the results showed no statistically significant differences between agents regarding symptom-free days. The heterogeneity and inconsistency analysis of the outcomes showed that there were no differences between the regimens. Conclusions: Our findings have shown that there were no statistically significant differences between the different regimens of LABA + ICS regarding the frequency of moderate or severe exacerbations, adverse events, and symptom-free days.
Evaluation of a digital health resource providing physiotherapy information for postnatal women in a tertiary public hospital in Australia.

Background Pregnancy and childbirth have a profound and lasting effect on the female body. Reduced length of postnatal hospital stay has impacted the ability of physiotherapy staff to provide early intervention and education on postnatal recovery and rehabilitation. A novel method of providing physiotherapy education to postnatal women was implemented in an attempt to meet consumer needs in the changing hospital environment. A digital health resource was developed and evaluated to determine consumer satisfaction and access. Methods Postnatal women admitted to the postnatal ward were invited to participate in a survey of the digital health resource during a 17-day recruitment period. A participant information sheet was provided to the patient and a signed consent form collected from those willing to participate. Online surveys were emailed to women at approximately 2 weeks postnatal and a thematic analysis of the responses was completed. Results A total of 88 women were recruited to the study during a 17-day recruitment period with a 30% response rate (n=27) to an online survey sent at approximately 2 weeks postpartum. Of the 27 respondents, 33% had watched the digital health resource and were able to provide feedback on resource content, format and length, as well as enablers and barriers to access and viewing habits. Survey responses indicated the resource was viewed only after discharge from hospital and most commonly on a mobile device. Most women engaged with the resource to learn more about their own recovery, and all women found the advice on pelvic floor exercise useful. Lack of time was the most commonly reported barrier to viewing the digital health resource. Conclusions This quality assurance project demonstrated the existing digital health resource provides useful information to women following discharge from the postnatal ward but strategies to improve awareness of the resource should be investigated further.
Myalgic encephalomyelitis: International Consensus Criteria

Abstract. Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, Staines D, Powles ACP, Speight N, Vallings R, Bateman L, Baumgarten‐Austrheim B, Bell DS, Carlo‐Stella N, Chia J, Darragh A, Jo D, Lewis D, Light AR, Marshall‐Gradisbik S, Mena I, Mikovits JA, Murovska M, Pall ML, Stevens S (Independent, Vancouver, BC, Canada; Independent, Calgary, AB, Canada; Department of Physiology and Medicine, Vrije University of Brussels, Himmunitas Foundation, Brussels, Belgium; Department of Medicine,University of Miami Miller School of Medicine and Miami Veterans Affairs Medical Center, Miami, FL, USA; Department of Medicine, University of Alberta, Edmonton, AB, Canada; Honorary Consultant for NHS at Peterborough/Cambridge, Lowestoft, Suffolk, UK; Gold Coast Public Health Unit, Southport, Queensland; Health Sciences and Medicine, Bond University, Robina, Queensland, Australia; Faculty of Health Sciences, McMaster University and St Joseph’s Healthcare Hamilton, Hamilton, ON, Canada; Independent, Durham, UK; Howick Health and Medical Centre, Howick, New Zealand; Fatigue Consultation Clinic, Salt Lake Regional Medical Center; Internal Medicine, Family Practice, University of Utah, Salt Lake City, UT, USA; ME/CFS Center, Oslo University Hospital HF, Norway; Department of Paediatrics, State University of New York, Buffalo, NY; Independent, Pavia, Italy; Harbor‐UCLA Medical Center, University of California, Los Angeles, CA; EV Med Research, Lomita, CA, USA; University of Limerick, Limerick, Ireland; Pain Clinic, Konyang University Hospital, Daejeon, Korea; Donvale Specialist Medical Centre, Donvale, Victoria, Australia; Departments or Anesthesiology, Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah, USA; Health Sciences and Medicine, Bond University, Robina, Queensland, Australia; Department of Medicina Nuclear, Clinica Las Condes, Santiago, Chile; Whittemore Peterson Institute, University of Nevada, Reno, NV, USA; Miwa Naika Clinic, Toyama, Japan; A. Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia; Department of Biochemistry & Basic Medical Sciences, Washington State University, Portland, OR; Department of Sports Sciences, University of the Pacific, Stockton, CA USA). Myalgic encephalomyelitis: International Consensus Criteria (Review). J Intern Med 2011; 270: 327–338.
Incidence and Clinical Characteristics of Post LASIK Ectasia: A Review of over 30,000 LASIK Cases

ABSTRACT Purpose: To report the incidence of postoperative ectasia after laser in situ keratomileusis (LASIK). Methods: A retrospective case review of 30,167 eyes (16,732 patients) was conducted following LASIK between August 2007 and August 2015. The follow-up was between 2 and 8 years. Tomography was performed after 2 years postop. After identifying cases of ectasia, the charts of these patients were examined to identify any common factors that may have predisposed them to develop ectasia. Results: Ten eyes of seven patients developed post-LASIK ectasia. Eight eyes had been treated for myopia and myopic astigmatism, two eyes for mixed astigmatism. There were no cases of ectasia after LASIK for hyperopia. All 10 cases of ectasia had a flap that was created using the Moria M2 mechanical microkeratome (average flap thickness 118.15 ± 12.88 µm) and refractive error corrected using the Wavelight Allegretto excimer laser. Retrospectively, most prevalent risk factors were thin cornea (≤ 500 µm, 50% of cases), anterior topographic map irregularities (e.g., asymmetric bow tie, 40% of cases), Ectasia Risk Score > 3 (40% of cases), percent tissue thickness alteration ≥ 40% (20% of cases) and low residual stromal bed (≤ 300 µm, 30% of cases). One eye had no identifiable risk factors. In the retrospective chart review 14.97% (4,506) of all the eyes had similar risk factors to the cases that went on to develop ectasia. Conclusion: The incidence of ectasia was 0.033% over 8 years. The incidence could be higher as some cases may destabilize beyond this period and some patients were lost to follow-up asymptomatic of any clinical signs. Other intrinsic factors may trigger the development of post LASIK ectasia. The current widely accepted risk factors are not sufficiently rigorous for screening out potential ectasia from developing after LASIK. There is a need to augment accuracy with higher sensitivity and specificity.
Offline Lower-Limb Kinematic Decodification by Segments of EEG Signals

In this work, hip and knee angles were decoded from low frequency EEG components recorded during the execution of two tasks. In order to compare their performance, three decoders based on multiple linear regression (MLR) models were applied under different conditions; which consisted in considering the processed data as a whole or divided into segments. Results suggest that, when the segments are related to specific tasks, the segmentation provides a better performance than applying the decoding method to unsegmented data.
You; the Observer, Partaker or Victim. Delineating Three Perspectives to Empathic Engagement in Persuasive Games using Immersive Technologies.

A commonality in socially-aware persuasive games is the strategy to appeal to empathy, as a means to have players feel and understand the struggles of another. This is particularly evident in the expanding use of immersive technologies, lauded for its ability to have players more literally 'stand in another's shoes'. But despite the growing interest, empathic engagement through immersive technologies is still ill-defined and the design thereof complicated, with questions like "who is the player? " and "with whom does the player empathize? ". We contend that a better understanding of the different perspectives to empathic engagement - the observer, partaker, and victim - and the gap between realities can be insightful, and resulted in a framework to support future research and design.
HUBUNGAN KECERDASAN EMOSIONAL DENGAN HASIL BELAJAR BIOLOGI SISWA KELAS X MIA MAN 3 MEDAN T.P. 2017/2018

This study aims to determine the relationship of emotional intelligence with learning outcomes Biology X class students MIA MAN 3 Medan Year Learning 2017/2018. The population in this study is all students of class X MIA MAN 3 Medan consisting of 5 classes. Sample used 2 classes from 5 classes with total 81 students. To obtain the data of emotional intelligence used questionnaire that has been validated by a validator lecturer. While the results of biology learning taken from the value of daily student ulagan obtained from teachers of Biology study. The data obtained are searched for the mean value, standard deviation, and test the data requirements. Emotional intelligence of students has ± SD of 91.30 ± 9.26, while the student's biology learning outcome is 78.37 ± 8.73. From the results of statistical analysis known the relationship of emotional intelligence with the results of biology students have a linear regression equation and have a meaningful relationship, this we can see from the high correlation coefficient of 0.871 and the amount of emotional intelligence contribution to student biology learning results of equal 75.69%. This means that emotional intelligence has a positive relationship with learning outcomes Biology X class student MIA MAN 3 Medan Year Learning 2017/2018.Keywords: Emotional intelligence, learning outcomes.
Decentralised Cooperative Mobile Manipulation with Adaptive Control Parameters

In this work a collaborative controller for a team of mobile manipulators is designed for transporting a rigid workpiece to a desired position and orientation. Impedance control is used for the robotic arms to allow some compliance in the physical contact. The mobile platform is localised with a Bayesian filter and controlled kinematically using a velocity reference composed of two parts: a) a velocity towards the goal position and the desired formation, and b) one that keeps the robot gripper in a proper range relative to the platform. According to the accuracy information from the localisation algorithm, the control gains are changed to reduce the motion error and internal forces on the workpiece. The system is decentralised and no communication between the robots is required. Simulation results are presented to illustrate the performance.
Patterns of Cardiometabolic Health as Midlife Women Transition to Menopause: A Prospective Multiethnic Study.

CONTEXT Cardiometabolic conditions increase in midlife, but early customized prevention strategies are not established for such women. OBJECTIVE To characterize and identify factors longitudinally related to constellations of cardiometabolic risk components in multiracial/ethnic women in midlife. DESIGN We conducted a prospective, longitudinal, multiethnic cohort study of 3003 midlife women undergoing menopausal transition (MT). Metabolic syndrome (MetS) was defined as having at least three of five components: high fasting triglyceride (hTG) level, low high-density lipoprotein cholesterol (lHDL-C) level, high fasting plasma glucose (hGluc) level, large waist circumference (abdominal obesity; Ob), and hypertension (HTN). We described the patterns of constellations and estimated hazard ratios (HRs) for constellations at (i) incident MetS and (ii) recovery from MetS, using multivariable-adjusted Cox regression. SETTING Seven US sites. PARTICIPANTS In all, 1412 non-Hispanic white, 851 black, 272 Japanese, 237 Hispanic, and 231 Chinese women. EXPOSURES Race/ethnicity, lifestyle factors, and MT stage. MAIN OUTCOMES MEASURES Cardiometabolic constellations, incident MetS, and MetS recovery. RESULTS Central obesity was the most frequent component. Having no components was the most frequent (31%) baseline constellation. Physical activity (HR = 1.68; 95% CI: 1.06, 2.68) and lower caloric intake (HR = 0.96; 95% CI: 0.93, 0.99 per 100 cal/d) were associated with recovery from MetS. Ob/hTG/lHDL-C (18%), Ob/HTN/lHDL-C (16%), and Ob/HTN/hGluc (14%) were frequent incident constellations. Physically active women had 26% to 62% lower hazards of incident MetS than inactive women. CONCLUSIONS Modifiable lifestyle behaviors were related to recovery from MetS and decreased risk of the most frequent MetS constellations in midlife women.
End-to-end authenticated key exchange agreement for wearable devices in IoT environments

Wearable devices become the most personal devices nowadays. The smartphone may become a second screen Internet of Things (IoT) future shaped by wearable devices as wearable devices get smarter. Wearable devices can accelerate speed of leading users to IoT, and the entrance of IoT will be wearable devices. A setback in wearable devices adoption might delay the overall adoption of the IoT among users, such as security issues. Service providers may utilize identity authentication and secure communication protocols for ensuring legitimacy of users and information transferring security. In this paper, we presented an end-to-end authenticated key exchange agreement for wearable devices in IoT environments. The protocol can satisfy some properties of key exchange agreement and be used with wearable devices in IoT environments.
Acute Sleep Restriction Has Differential Effects on Components of Attention

Inadequate nightly sleep duration can impair daytime functioning, including interfering with attentional and other cognitive processes. Current models posit that attention is a complex function regulated by several separate, but interacting, neural systems responsible for vigilance, orienting, and executive control. However, it is not clear to what extent each of these underlying component processes is affected by sleep loss. The purpose of this study was to evaluate the effects of acute sleep restriction on these attentional components using the Dalhousie Computerized Attention Battery (DalCAB). DalCAB tasks were administered to healthy women (aged 19–25 years) on two consecutive mornings: once after a night with 9 h time in bed (TIB), and once again after either another night with 9 h TIB (control condition, n = 19) or after a night with 3 h TIB (sleep restriction condition, n = 20). Self-ratings of sleepiness and mood were also obtained following each sleep condition. Participants showed increases in self-reported sleepiness and fatigue after the second night only in the sleep restriction group. Sleep restriction primarily affected processing speed on tasks measuring vigilance; however, performance deficits were also observed on some measures of executive function (e.g., go/no-go task, flanker task, working memory). Tasks assessing orienting of attention were largely unaffected. These results indicate that acute sleep restriction has differential effects on distinct components of attention, which should be considered in modeling the impacts of sleep loss on the underlying attentional networks.