Miracle-dz/UniFAR-FTUs huggingface dataset:
Revenue and Energy Cost-Optimized Biobjective Task Scheduling for Green Cloud Data Centers

The significant growth in the number and types of tasks of heterogeneous applications in green cloud data centers (GCDCs) dramatically increases their providers’ revenue from users as well as energy consumption. It is a big challenge to maximize such revenue, while minimizing energy cost in a market where prices of electricity, availability of renewable power generation, and behind-the-meter renewable generation contract models differ among the geographical sites of the GCDCs. A multiobjective optimization method that investigates such spatial differences in the GCDCs is for the first time proposed to trade off such two objectives by cost-effectively executing all tasks while meeting their delay constraints. In each time slot, a constrained biobjective optimization problem is formulated and solved by an improved multiobjective evolutionary algorithm based on decomposition. Realistic data-based simulations prove that the proposed method achieves a larger total profit in faster convergence speed than the two state-of-the-art algorithms. Note to Practitioners—This article considers the tradeoff between profit maximization and energy cost minimization for the green cloud data center (GCDC) providers while meeting the delay constraints of all tasks. Current task-scheduling methods fail to take the advantage of spatial variations in many factors, e.g., prices of electricity and availability of renewable power generation at geographically distributed GCDC locations. As a result, they fail to execute all tasks of heterogeneous applications within their delay bounds in a high-revenue and low-energy-cost manner. In this article, a multiobjective optimization method that addresses the disadvantages of the existing methods is proposed. It is realized by a proposed intelligent optimization algorithm. Simulations demonstrate that in comparison with the two state-of-the-art scheduling algorithms, the proposed one increases the profit and reduces the convergence time. It can be readily implemented and integrated into actual industrial GCDCs.
Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects

Background Recent efforts have been focused on combining two or more therapeutic approaches with different mechanisms to enhance antitumor therapy. Moreover, nanosize drug-delivery systems for codelivering two drugs with proapoptotic and antiangiogenic activities have exhibited great potential in efficient treatment of cancers. Methods Glycyrrhetinic acid (GA)–modified liposomes (GA LPs) for liver-targeted codelivery of curcumin (Cur) and combretastatin A4 phosphate (CA4P) were prepared and characterized. In vitro cellular uptake, cytotoxicity, cell migration, in vivo biodistribution, antitumor activity, and histopathological studies were performed. Results Compared with unmodified LPs (Cur-CA4P LPs), Cur-CA4P/GA LPs were taken up effectively by human hepatocellular carcinoma cells (BEL-7402) and showed higher cytotoxicity than free drugs. In vivo real-time near-infrared fluorescence–imaging results indicated that GA-targeted LPs increased accumulation in the tumor region. Moreover, Cur-CA4P/GA LPs showed stronger inhibition of tumor proliferation than Cur, Cur + CA4P, and Cur-CA4P LPs in vivo antitumor studies, which was also verified by H&E staining. Conclusion GA-modified LPs can serve as a promising nanocarrier for liver-targeted co-delivery of antitumor drugs against hepatocellular carcinoma.
Spinal anesthesia-induced hypotension is caused by a decrease in stroke volume in elderly patients

Background Hypotension is common during spinal anesthesia (SA) and is caused by a decrease in systemic vascular resistance (SVR) and/or cardiac output (CO). The effect of the dose of bupivacaine administered intrathecally on the changes in CO in elderly patients is largely unknown. This study investigated the hemodynamic effect of SA in elderly patients by studying the effect of two different dosages of intrathecal bupivacaine. Methods This prospective cohort study included 64 patients aged >65 years scheduled for procedures under SA; the patients received either 15 mg bupivacaine (the medium dose [MD] group) or 10 mg bupivacaine and 5 μg sufentanil (the low dose [LD] group). Blood pressure and CO were monitored throughout the procedure using Nexfin™, a noninvasive continuous monitoring device using a finger cuff. Results Thirty-three patients received MD and 31 received LD and there was no mean difference in baseline hemodynamics between the groups. On an average, the CO decreased 11.6% in the MD group and 10.0 % in the LD group. There was no significant change in SVR. Incidence of a clinically relevant decrease in stroke volume (SV) (>15% from baseline) was 67% in the MD and 45% in the LD groups (P<0.05). Conclusion CO and blood pressure decreased significantly after the onset of SA in elderly patients. This is mainly caused by a decrease in SV and not by a decrease in SVR. There was no difference in CO and blood pressure change between dosages of 10 or 15 mg bupivacaine.
COPD patients’ characteristics, usual care, and adherence to guidelines: the Greek UNLOCK study

Purpose GOLD guidelines classify COPD patients into A–D groups based on health status as assessed by COPD Assessment Test (CAT) or mMRC tools and exacerbations and recommend single or dual long-acting bronchodilators as maintenance therapy, with additional inhaled corticosteroids (ICS) if the disease remains uncontrolled. We aimed to classify primary care COPD patients into A–D groups, assess usual treatment and adherence to guidelines, potential mismatches between CAT-and mMRC-based classification and described symptoms within groups. Patients and methods A total of 257 primary care COPD patients were enrolled between 2015 and 2016 in Greece. Physicians used structured interviews to collect cross-sectional data including demographics, symptoms, CAT, mMRC scores, and medications. Patients were classified into A–D groups based on CAT and mMRC, and prevalence of symptoms and medication was estimated within A–D groups. Interviews with physicians were also performed to explore additional issues about treatment and adherence to guidelines. Results Mean (SD) age was 65 (12.3) years with 79% males. The majority of patients reported uncontrolled symptoms (91% and 61% with ≥10 CAT or ≥2 mMRC scores, respectively). Thirty-seven percentage had $2 exacerbations in the past year. Group B was the largest followed by Groups D, A, and C. Patients were classified as more severe by CAT than by mMRC. In all groups, the majority were treated with combined long-acting beta agonist/ICS (> 50%). When patients were asked to report their main symptoms, dyspnea and cough were the most important symptoms mentioned, and there was a great variation between the A–D groups. However, Groups A–C reported mainly morning symptoms, whereas Group D suffered symptoms all day. Physicians reported a significant number of barriers to implementing guidelines, eg, frequent lack of guideline updates, access to diagnostic procedures, and prescription-reimbursement issues. Conclusion Our study confirms poor adherence to guidelines regarding treatment with an overuse of ICS and important barriers to implementation. A mismatch in classification occurs depending on the tool used, which can mislead clinicians in their choice of treatment.
Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system

Background Infliximab (Remicade), a chimeric monoclonal antibody against human TNFα, will inevitably face competition from biosimilar products, because of its effectiveness in autoimmune diseases and rapidly increasing market demand. According to guidelines for biosimilar development, the “biosimilar-expression system” may differ from that of the innovator, but more appropriate studies should be carried out to demonstrate the comparability between biosimilar and innovator. CMAB008 is an infliximab biosimilar candidate developed by the State Key Laboratory of Antibody Medicine and Targeted Therapy of China. Infliximab was expressed in SP2/0 cells, while CMAB008 was produced in a CHO-expression system. Methods In this study, infliximab and CMAB008 were compared on physicochemical and biological characterizations, including protein content, activity, physiochemical integrity, impurities, additives, and immunogenicity. Results The results showed that they were highly similar and comparable, except some differences in glycosylation. As glycosylation profiles can influence immunogenicity and occurrence of allergy or other adverse reactions of antibody therapeutics, primary tolerability and pharmacokinetics of CMAB008 were evaluated. In the phase I clinical trial, plasma concentration of CMAB008 and antidrug antibodies were also measured using ELISA and bridging ELISA, respectively. CMAB008 exhibited favorable clinical tolerability, no adverse events in the 3 mg/kg single-dose group (recommended therapeutic dosage), and no serious adverse events in the multiple-dose group. Also, no injection-site reactions were observed in the experiment. Conclusion In summary, CMAB008 might have the potential to be an effective drug compared with infliximab.
Innowacyjność jako determinanta relacji koopetycyjnych

Celem artykułu jest pokazanie relacji pomiędzy innowacyjnością gospodarki, sektora i organizacji a koopetycją jako ważnego i ciekawego pola badawczego dla przyszłych badań teoretycznych i empirycznych. Relacja ta nie była dotychczas częstym tematem badań, co sprawia, że jest to interesujący obszar rozważań naukowych. Artykuł ma charakter teoretyczny, w którym wykorzystano wnioskowanie dedukcyjne. Postępowanie badawcze pozwoliło zidentyfikować najważniejsze zewnętrzne (presja ze strony klientów, zaawansowanie technologiczne, podatność sektora na globalizację oraz ostrą walkę konkurencyjną) oraz wewnętrzne (komplementarność zasobów, elastyczność, zdolność do wykorzystywania okazji oraz pozycja konkurencyjna) determinanty koopetycji. Przedstawione rozważania pozwoliły autorowi sformułować wniosek, że wpływ innowacyjność gospodarki, sektora oraz organizacji na skłonność do tworzenia oraz rozwijania relacji koopetycji jest niejednoznaczny. Ważne jest więc dalsze eksplorowanie analizowanej relacji na gruncie teoretycznym i empirycznym.
Combined-SLED source for UHR-OCT and SLO integrated in 14-pin butterfly module

We demonstrate a novel light source for multi-modality imaging where three superluminescent diodes (SLEDs) are integrated on a free-space, temperature-stabilized, micro-optical bench in a standard 14-pin butterfly package. The light output of the three SLED chips is collimated by individual micro-optical collimation lenses and then spectrally and spatially combined in free space through dielectric edge filters before being coupled into a common HI-780 single-mode output fiber. The two SLEDs at 840 nm and 880 nm deliver a combined broadband spectrum with 120 nm bandwidth and 8.5 mW of output power for ultra-high-resolution optical coherence tomography (OCT) imaging with an axial resolution of ~4 microns in air. The third SLED at 750 nm is suitable for implementing eye tracking based on a scanning laser ophthalmoscope (SLO). Because of the free-space architecture, the polarization of all SLEDs is intrinsically aligned such that the UHR-OCT broadband source has a high PER of 20 dB across the entire spectrum.
Implementación del modelo cinemático y dinámico y control de movimiento de un mecanismo planar 2R con componentes elásticos en las articulaciones

En esta tesis se desarrollan los modelos matematicos de la cinematica y dinamica y una estrategia para el control de movimiento de un mecanismo planar 2R, el cual imita el movimiento de la cadera y la rodilla en el plano sagital durante la marcha humana y posee componentes elasticos en las articulaciones. Se inicia con una revision bibliografica de algunos metodos para el control de movimiento de Sistemas de Accionamiento Flexible, haciendo enfasis en aplicaciones roboticas, dispositivos de rehabilitacion de miembro inferior y Actuadores Elasticos Seriales (SEA), correspondiendo estos ultimos a los utilizados en el mecanismo. A continuacion se desarrollan los modelos matematicos, determinando la cinematica directa a partir del metodo de Denavit-Hartenberg y la dinamica inversa a partir del metodo de LagrangeEuler. Estos modelos se implementan posteriormente para predecir el movimiento de los actuadores en funcion del movimiento de las articulaciones, cuyos resultados se comparan con los obtenidos en pruebas realizadas al equipo real. Finalmente se desarrolla la estrategia para el control de movimiento del mecanismo, para lo cual se realizaron pruebas de desempeno a los controladores internos en los actuadores; a partir de estos resultados se desarrollo, implemento y evaluo un algoritmo basado en una forma simplificada del control adaptativo por planificacion de ganancias, usando dos puntos de ajuste de los parametros en los controladores internos y tomando como criterio de evaluacion las desviaciones angulares entre cada articulacion y su actuador.
Statins and sudden cardiac death - mini review on available data

Sudden cardiac death (SCD) is defined as an unexpected natural death from a cardiovascular (CV) cause that occurs within 1 hour of symptom onset [1]. Globally SCDs account for 15–20% of all deaths. In the USA and Europe the highest annual incidence of SCD, ranging from 50 to 100 per 100 000 persons, is noted [2]. Nowadays SCD remains an important clinical and public health issue. SCD is the consequence of complex interaction between upstream determinants (such as age, sex, socioeconomic status, CV risks factors and genetic predisposition), a variety of cardiac conditions and environmental triggers [3]. 80% cases of SCD occur as a result of coronary artery disease (CAD); consequently, risk factors of CAD also predispose to SCD [4]. Other important risk factors for SCD are diabetes mellitus (DMt2)[5] and heart failure (HF)[6]. In most cases SCDs result from ventricular tachycardia (VT) and ventricular fibrillation (VF)[7]. Fatal ventricular arrhythmias in patients with CAD are mainly associated with two mechanisms: acute coronary ischemia, generally resulting from plaque rupture; and re-entry associated with areas of slow conduction and previous myocardial scarring[8]. Statins are the most effective drugs used to reduce endogenous production of cholesterol[9]. Besides their lipid-lowering effects, statins exhibit pleiotropic properties such as anti-inflammatory[10], antioxidant [11], antihypertrophic and antifibrotic effects, which might play a role in CV protection[12]. Statins can slow the progression or even induce regression of atherosclerosis [13], which may reduce myocardial ischemia, which can cause ventricular arrhythmias, and in consequence reduce the risk of SCD [14]. Large scale clinical trials indicated that statins reduce CV morbidity and mortality in high-risk populations [15]. Therefore, the purpose of the present review is to synthesize the results of recent studies on the influence of statin therapy on sudden cardiac death.
Phosphorus Fractions in the Sediments of Yuecheng Reservoir, China

As a result of the inexorable development of the economy and the ever-increasing population, the demand for water in the urban and rural sectors has increased, and this in turn has caused the water quality and eutrophication of the reservoir to become a legitimate concern in the water environment management of river basins. Phosphorus (P) is one of the limiting nutrients in aquatic ecosystems; P in the sediment is a primary factor for eutrophication. Yuecheng Reservoir is located in one of the most productive and intensively cultivated agricultural regions in North China. Detailed knowledge of the sediment is lacking at this regional reservoir. The first study to look into the different P fractions and its diffusion fluxes at the water sediment interface of the Yuecheng Reservoir makes it possible to learn about the internal P loading. According to the results, the concentrations of total phosphorus (TP) ranged from 1576.3 to 2172.6 mg kg and the P fraction concentration sequence is as follows: P associated with calcium (Ca–Pi) > organic P (Po) > P bound to aluminum (Al), ferrum (Fe) and manganese (Mn) oxides and hydroxides (Fe/Al–Pi). The results demonstrated that, although the construction of a large number of water conservancy projects in the upper reaches of the river resulted in the decrease of inflow runoff, the pollutions from terrestrial plants or materials played a key role in the sediment phosphorus fraction, and they should be emphasized on the water environment management of river basin.
Websites Designed for Students with Special Needs

According to Friedman & Bryen, (2007), a person with a disability is one with a long-term physical, intellectual, mental or sensory impairment, which interferes with their social equality in relation to others. Disability, thus, varies widely across countries. Borg, Berman-Bieler, & Khasnabis (2015), indicated that by 2004, about 93 million children aged 14-years and below, suffered from moderate to severe disabilities. Examples of common disabilities include hearing loss, down syndrome, cerebral palsy, brain injury, intellectual and learning disability, congenital anomalies, muscular dystrophy, blindness, spinal code injuries, visual loss and speech impairments (Borg, Berman-Bieler, & Khasnabis, 2015) Assistive technology has become a common term in discussions regarding children with disabilities. This term includes technology, which assists disabled persons to carry out their activities or to facilitate their activities. They include technologies used to facilitate mobility, vision, hearing, communication and cognition. This paper will explore how web designs can be used to assist in the learning process. One such common disability is that of dyslexia, which is a medical condition that makes it difficult for students to read and learn and which lends itself well to assistive technologies (HKSAR, 2008). It is estimated that one in every 10 people have dyslexia (HKSAR, 2008). The condition exists across a range of cultures, abilities and conditions and is usually gene related and thus, runs in the family. While it cannot be cured, there are practical approaches that can help overcome the barriers presented by the condition. Dyslexia can be termed as a learning difference meaning that the brain approaches tasks differently to other people and affects the way people communicate (HKSAR, 2008). Since dyslexia does not affect the individual’s intelligence, it can be managed by using a different communication model in the learning process (Friedman & Bryen, 2007). Assistive technology such as the use of specialized websites can, therefore, be used to assist children with dyslexia. Keywords: Dyslexia, Cognitive Disability, Technology, Accessibility, and Autism. DOI : 10.7176/JEP/10-30-14 Publication date :October 31 st 2019
Research on gamma spectrum semi-quantitative analysis based on convolutional neural network

In the field of practical application of nuclear technology, one of the vital steps is the interpretation of gamma energy spectrum, which can obtain the type and content of radionuclides and achieve further analyzation. Convolutional neural network is one the most basic and effective algorithm structures in deep learning because it has local receptive field, weight sharing and down sampling structure, it solves the problem of parameter expansion caused by full connection and reduces the number of weights. That can be used to study the resolution of gamma-ray spectra of convolutional neural networks. This paper introduces the spectral forming principle of gamma spectra and the convolutional neural network, and USES the convolutional neural network to study the spectral decomposition of gamma spectra. In this paper, a multi-layer convolution neural network model is built based on C# software. The convolution neural network is applied to gamma-ray spectrum decomposition, and the U, Th, K nuclides are identified and semi-quantitatively calculated. By identifying and analysing different energy spectrum data, it is shown that the modified model structure can be applied to the spectral decomposition of gamma spectrum.
Profiling the Facial Comparison Practitioner in Australia

As part of a joint University of Adelaide-Defence Science and Technology Group project, known as the Human Operator Capability Project, a comprehensive survey of 149 facial comparison practitioners within Australian State and Federal Government agencies was conducted in late 2010. The survey collected data in a range of categories including: demographics, training and work history, facial comparison tools and techniques, attitudes to the facial comparison task and the use of facial recognition systems. This report outlines the key findings from the survey, including implications for the consideration of participating agencies at the time. An epilogue reflects on what has changed in the time since the survey was conducted.
Epstein-Barr virus-associated post-transplantation lymphoproliferative disorder as a complication after cadaveric lung transplantation following allogeneic hematopoietic stem cell transplantation

A 35-year-old man developed bronchiolitis obliterans（BO）after unrelated allogeneic bone marrow transplanta-tion（BMT）for T-cell acute lymphoblastic leukemia. He had received cadaveric lung transplantation（CLT）4 years and 3 months after BMT. Seven months following BMT, multiple hepatic lesions were identified. Biopsy results of the lesions revealed infiltration of lymphoma cells. Immunostaining of the biopsy was positive for CD20, CD79a, and Epstein-Barr virus（EBV）encoded small RNA, and the kappa light-chain restriction was revealed by flow cytometric analysis. This analysis led to a diagnosis of EBV-associated monomorphic post-transplantation lymphoproliferative disorder（PTLD）. Despite the reduction of the immunosuppressive dosage and administration of rituximab, the patient died seven days after the onset of therapy. allogeneic of complication PTLD there is potential to reduce or even terminate immunosuppression with living-donor lobar lung transplantation using the same donor as for allo-HSCT, is to this with CLT. An in the number of cases of CLT after allo-HSCT for the associated We report the case of a 45-year-old male patient who developed human herpesvirus 6 (HHV6)-associated pleurisy after an unrelated cord blood transplantation (CBT) for acute lymphoblastic leukemia. A large amount of pleural effusion accompanied by interstitial pneumonitis was noted on the right side on day 37 post-transplantation. A real-time quantitative PCR (RQ-PCR) assay revealed that the HHV6 viral load was substantially higher in the pleural effusion than in the peripheral blood plasma at the onset of pleurisy, with 2.2 × 10 2 and 7.9 × 10 3 copies of HHV6 DNA/mL in the peripheral blood plasma and the supernatant of the pleural effusion, respectively. Moreover, HHV6 DNA was still detected in the pleural effusion after antiviral therapy. Therefore, the pleural cavity may have been the primary site of HHV6 replication in the present case. To our knowledge, the present study is the first detailed report of adult HHV6-associated pleurisy after CBT. HHV6-associated pleurisy should be considered a potential complication when pleural effusion of unknown cause is encountered after CBT, even in the absence of HHV6 DNA in the peripheral blood. (Journal of Hematopoietic Cell Transplantation 3(2): 59-63, 2014. )