Miracle-dz/UniFAR-FTUs huggingface dataset:
Genomic study of oral lichen planus and oral microbiome with RNAseq

Oral lichen planus (OLP) is a common chronic inflammatory disease affecting the oral mucosa. The pathogenesis of OLP is incompletely understood but is thought to be related to the immune system. As the oral cavity is a major reservoir and transmission gateway for bacteria, viruses, and fungi, the microbial composition of the oral cavity could play a role in the pathogenesis of OLP. However, due to limitations of analytic technology and incomplete knowledge of the microbial community in the oral cavity, it is not yet clear which pathogens are associated with OLP. Next-generation sequencing (NGS) is a powerful tool that can help to identify pathogens for many infectious diseases. In this study, we compared host cell gene expression profiles and microbial profiles from OLP patients and matched healthy individuals. We identified activation of the hepatocyte nuclear factor alpha (HNF4A) network in OLP patients and potential pathogens, including Corynebacterium matruchotii, Fusobacterium periodonticum, Streptococcus intermedius, Streptococcus oralis, and Prevotella denticola. P. denticola is capable of activating the HNF4A gene network. Our findings shed light on the previously elusive association of OLP with various diseases like hepatitis, and indicate that OLP is a T-helper type 17 (Th17)-mediated mucosal inflammatory process. The molecular pathways and microbes identified here can inform future investigations into OLP pathogenesis and development of novel therapeutics for OLP treatment.
Malnutrition et épilepsie : des liens complexes Malnutrition and epilepsy: Complex links

A link between malnutrition and epilepsy has been suspected for many years. Several studies which have been performed on animal models or on humans highlighted the adverse effects of malnutrition in the onset of seizures. Proteinoenergetic, electrolytes, vitamine or trace-element deficiencies could be implied. The possible negative effect of epilepsy on nutritional status has also been studied, with several determinants leading to malnutrition: foods which are forbidden during epilepsy in developing countries and probably in France, social exclusion which is common for people with epilepsy, role of antiepileptic diets or treatments on appetite for example. Two different hypotheses exist as a vicious circle: malnutrition predisposing to epilepsy or conversely epilepsy predisposing to malnutrition. © 2008 Elsevier Masson SAS. Tous droits reserves.
Immunodiagnostic Potential of an In-Vitro Interferon-Gamma Release Assay for Latent Tuberculosis Infection Among Apparently Healthy Individuals in Okada Community, Nigeria

A major challenge in the global Tuberculosis (TB) control is the diagnosis and treatment of Latent Tuberculosis Infection (LTBI). In the absence of any reference standard test for the diagnosis of LTBI, this study set out to compare the performance of the two current immune-based tests, Tuberculin Skin Test (TST) and Quantiferon–TB Gold In–Tube (QFT-GIT) ELISA in the diagnosis of LTBI. Two sets of diagnostic results for 196 apparently healthy volunteers from a cross-section of Okada Community, Edo State, Nigeria were compared in terms of age, occupation, BCG-vaccination status, prior TST and cigarette smoking history. Overall, 56 (28.6%) and 81 (41.3%) of the subjects were diagnosed with LTBI by the QFT-GIT test and TST respectively. The LTBI prevalence as assessed by the QFT-GIT test was significantly higher among the non-BCG-vaccinated, compared to the BCG-vaccinees (X2=18.79, df=1, p=0.0001). The highest concordance (QFT-GIT+ve/TST+ve) was found in the occupation categories (Ʀ=-0.009, p=0.747) and the highest discordance(QFT-GIT –ve/TST +ve) was with respect to the BCG-vaccination status (Ʀ=-0.194, p=0.046). The disparity in the performance of the two tests is attributable to the high false – positive TST results, which is a direct reflection of high (90.8%) BCG vaccination level among the study population. It is advocated that the two-step testing approach, using the QFT-GIT assay as a confirmatory test for LTBI after initial positive screening by the TST, be introduced into the TB control strategy in TB – laden communities with high BCG vaccination coverage.
A systematic literature review of students as partners in higher education

“Students as Partners” (SaP) in higher education re-envisions students and staff as active collaborators in teaching and learning. Understanding what research on partnership communicates across the literature is timely and relevant as more staff and students come to embrace SaP. Through a systematic literature review of empirical research, we explored the question: How are SaP practices in higher education presented in the academic literature? Trends across results provide insights into four themes: the importance of reciprocity in partnership; the need to make space in the literature for sharing the (equal) realities of partnership; a focus on partnership activities that are small scale, at the undergraduate level, extracurricular, and focused on teaching and learning enhancement; and the need to move toward inclusive, partnered learning communities in higher education. We highlight nine implications for future research and practice.
Adverse drug reaction in HIV-infected people treated with HAART in Maringá, Southern Brazil

Purpose: To assess the knowledge of adverse drug reactions (ADRs) among HIV-infected patients on prolonged treatment with highly active antiretroviral therapy (HAART) at a public health facility in Maringa, Southern Brazil. Methods: A retrospective and prospective analysis of laboratory results and clinical epidemiological characteristics was conducted among 220 HIV-infected patients treated with HAART between January 2010 and December 2013, at a public health care and treatment center in Maringa, Southern Brazil. The immunological and virological profiles of participants were evaluated. Results: The mean age of antiretroviral therapy (ART) participants was 44.3 ± 10.8 years and there was no substantial age difference between males and females. The mean of the first and last CD4+ T count were 550 ± 309 cells/μL and 642 ± 372 cells/μL, respectively. Similarly, the first and last mean viral load were 14,476 ± 58,067 copies/mL and 20,828 ± 106,028 copies/mL, respectively. The therapeutic regimen was either two nucleoside reverse transcriptase inhibitors (NRTIs) and one protease inhibitor (PI) in 102 (46.4 %) patients, or two NRTIs and one non-nucleoside reverse inhibitor (NNRTI) in 79 (35.9 %). Gastrointestinal disorders (25.9 %), hypertension (25.4 %), and neuropsychiatric symptoms (18.2 %) were the most common clinical ADRs. The most common laboratory-based ADRs were anemia (48.8 %), hypertriglyceridemia (47.3 %), hypercholesterolemia (36.1 %) and hyperglycemia (22.6 %). Conclusion: The results demonstrate a high incidence of ADRs in HIV-patients treated with HAART, which should be monitored closely during follow-up therapy. Keywords: HIV, AIDS, Highly active antiretroviral therapy (HAART), Adverse drug reaction
CALCIUM REGULATORY MECHANISM IN VERTEBRATE SMOOTH MUSCLE

The general features of myofilaments in vertebrate smooth muscle are briefly summarized on the basis of electron microscopic observations. The crucial role of Ca” in smooth muscle is discussed, ranging from membrane phenomena to the contractile process in vitro. Discussion is focused on the regulatory mechanism of Ca“ at the protein level, for which two different concepts have been proposed. Our standpoint is to explain the activation of the actomyosin system by the action of leiotonin-tropomyosin in the presence of Ca“, while the other is to ascribe the regulation of contraction and relaxation to phosphorylation-dephosphorylation of the myosin P light chain. Our new results add some critical comments to the latter concept.
Evaluation of CD4 and CD8 in Patients Infected with Genital Wart Caused by Human Papilloma Virus in Babylon Province/Iraq

Genital warts it’s a skin projection due to human papilloma virus infection (HPV) . Thirty skin lesion and sera were collected from patient (females) infected with genital warts that visit dermatological department of medical Moran city. Twenty sera was collected from healthy person used as control group. The diagnosis of viral infectionwas achieved by dermatologist (specialist) and by using IgG anti HPV ELISA kit to detect papilloma virus in human serum, and ELISA testwas used to evaluate the level of CD4 and CD8 at patient with genital warts. The result demonstrates that:- 99% of samples dedicate positive for IgG anti HPV. Immunological study revealed that :- decrease the ratio of CD4/CD8 at patient with genital wart( ratioCD4/CD8:-0.1), decrease in CD4 level at patient infected with genital warts compared with control group . CD8 increased at patient with genital warts compared with control group. There is significant differences between patient and control group, p value ≤ 0 . 05. Keywords : HPV, Genital wart, CD4, CD8, Koliocyte.
Retail Trading and Momentum Profitability

Monthly momentum returns increase monotonically across quintile portfolios of stocks sorted by retail trading participation with a top-minus-bottom spread of 1.42% (t-statistics = 3.46). Stocks that are heavily traded by retail investors exhibit lottery-like features such as low prices, high idiosyncratic volatilities/skewness, and high past maximum returns. Using lottery characteristics to proxy for the extent of retail trading, future momentum profits monotonically increase in the cross-sectional lotteryness of stocks over a 77-year back-testing period for which retail trading data is unavailable. Further analysis shows that lottery-like stocks exhibit stronger comovements that amplify momentum profits.
A phase I/II trial of the combination of romidepsin and lenalidomide in patients with relapsed/refractory lymphoma and myeloma: Phase I results.

8582 Background: Epigenetic manipulation and immunomodulation are therapeutic strategies in hematologic malignancies. Romidepsin (Romi), a histone deacetylase inhibitor, and lenalidomide (Len), an immunomodulatory agent, both have efficacy and lack cumulative toxicity in relapsed/refractory (rel/ref) lymphoma and myeloma. We report the phase I results from an ongoing phase I/II study. Methods: The phase I portion evaluated toxicity (tox), maximum tolerated dose (MTD) and clinical activity of Romi-Len. Romi was given IV on days 1, 8, and 15 and Len was given orally on days 1-21 of a 28-day cycle. A standard 3+3 dose escalation schema was followed and 4 cohorts were planned: 1) Romi 8 mg/m2-Len 15 mg, 2) Romi 8 mg/m2-Len 25 mg, 3) Romi 10 mg/m2-Len 25 mg, 4) Romi 14 mg/m2-Len 25 mg. Dose-limiting tox (DLT) was defined as any of the following in cycle 1: ≥ grade 3 non-heme tox, ≥ grade 4 heme tox or grade 3 heme tox resulting in a significant delay of treatment. Tumor response was based on disease-specific c.
Manajemen Bronkopneumonia pada Bayi 2 Bulan dengan Riwayat Lahir Prematur

Angka kematian anak akibat pneumonia lebih dari 2 juta setiap tahun di dunia dan kematian bayi mencapai sebesar 27,6% dan kematian balita sebesar 22,8% di Indonesia. Bayi dengan riwayat preterm merupakan faktor resiko yang menyebabkan tingginya angka mortalitas pneumonia pada anak balita di negara berkembang. Data primer diperoleh dari alloanamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. bronkopneumonia dapat ditegakkan karena pada pasien ditemukan 4 dari 5 gejala berdasarkan kriteria diagnosis sesuai dengan teori Bradley et al, tahun 2011 yaitu didapatkan sesak nafas disertai dengan pernafasan cuping hidung dan tarikan dinding dada, ronkhi basah sedang nyaring (crackles), foto thorax menunjukkan gambaran infiltrat difus dan leukositosis. Dilakukan analisa kasus seperti adanya penyakit yang mendasari atau faktor risiko lain. Penatalaksaaan bronkopneumonia sudah berhasil, terbukti dengan gejala sesak pada pasien berkurang. Kata kunci: berat lahir rendah , bronkopneumonia, faktor predisposisi
Depression - Symptoms, Causes, Medications and Therapies

1. Department of pharmaceutical sciences, Karpagam University, Coimbatore, Tamil Nadu, India 2. Coimbatore medical college, Coimbatore, Tamil Nadu, India 3. R.K. Pharmacy college, Kashipur, Azamgarh Depression is the most common of the affective disorders; it may range from a very mild condition, bordering on normality, to severe (psychotic) depression accompanied by hallucinations and delusions. Worldwide, depression is a major cause of disability and premature death. When the negative reactions to life`s situations become repetitively intense and frequent we develop symptoms of depression. Life throws up innumerable situations, which we greet with both negative and positive emotions such as excitement, frustration, fear, happiness, anger, sadness. Depression is prevalent among all age groups, in almost all walks of life. Indians are among the world's most depressed. According to a World Health Organization-sponsored study, while around 9% of people in India reported having an extended period of depression within their lifetime, nearly 36% suffered from what is called Major Depressive Episode (MDE). MDE is characterized by sadness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, low energy and poor concentration, besides feeling depressed. Lowest prevalence of MDE was in China (12%). The average age of depression in India is 31.9 years compared to 18.8 years in China, and 22.7 years in the US. The female: male ratio was about 2:1. "WHO ranks depression as the fourth leading cause of disability worldwide and projects that by 2020, it will be the second leading cause. Keyword: Depression, Major Depressive Episode, global burden of disease, Antidepressant medications
Controversies of TreatmentModalities for Cerebral Venous Thrombosis

Cerebral vein thrombosis has been well recognized for nearly two centuries. However, therapeutic options for the condition are limited due to lack of large randomized trials. The various modalities reportedly used include antiplatelets, anticoagulation, fibrinolysis, and mechanical thrombectomy. Of these, antiplatelets are the least studied, and there are only anecdotal reports of aspirin use. Anticoagulation is the most widely used and accepted modality with favorable outcomes documented in two randomized controlled trials. Various fibrinolytic agents have also been tried. Local infusions have shownmore promise compared to systemic agents. Similarly, mechanical thrombectomy has been used to augment the effects of chemical thrombolysis. However, in the absence of randomized controlled trials; there is no concrete evidence of the safety and efficacy of either of these modalities. Limited study series disclosed that decompression surgery in malignant CVT can be life saving and provides good neurological outcome in some cases. Conclusion. Overall therapeutics for CVT need larger randomized controlled trials. Anticoagulaion with heparin is the only modality with a reasonable evidence to support its use in CVT. Endovascular thrombolysis and mechanical thrombectomy are reserved for selected cases who fail anticoagulation and decompression surgery for malignant CVT with impending herniation.
Formation of Siderite in Microbial Microcosms Derived from a Marine Sediment

Abstract Exceptionally well-preserved fossils are frequently encased by carbonate concretions. The initial steps of their formation in marine and freshwater sediments are induced by microbial activity. The role of the involved microbial communities, however, is not well understood. In this study, siderite (FeCO3) formation in microbial microcosms is observed, with various fatty acyl compounds (lipids, surfactants) as substrates and Wadden Sea sediment samples as inocula. In actively growing microcosms, sulfate-reducing bacteria (the genus Desulfofrigus in particular) dominate the microbial community and submicroscopic siderite precipitates on bacterial cell surfaces were identified. We suggest that these biologically induced mineralization processes may, in the natural environment, initiate the formation of large concretions under suboxic conditions in coastal sediments.
Optimized Power System Management Scheme for LSS PV Grid Integration in Malaysia Using Reactive Power Compensation Technique

A large‐scale solar photovoltaic system (LSS PV) aims to reduce the gap as Malaysia plans to shift electricity generation from conventional sources like fossil fuels to renewable energy sources. The government plans to increase renewable energy to 20% of the generation mix by 2025. The first and second round of Malaysia's LSS programme has 958 MW of PV projects to be realized by 2020. The third round of the LSS program goes for an aggregate capacity of 500 MW. Being an intermittent source of energy, the major complication is with grid integration of the LSS PV system into the national power grid. This research aims to identify an optimum power system management scheme for LSS in Malaysia to stabilize voltage fluctuations by utilizing IEEE bus configuration. The simulation and planning of network type is based on PSS/E and PVSyst. The expected outcome of this research is to develop a solution for LSS grid integration with minimal loss in the system and in accordance with electricity standards as per Malaysian grid code. Additionally, the harmony of incorporating power electronic devices for reactive power compensation is tested. This work can be stated as a reference model for utility provider in other countries having similar network and grid configuration.
Sentence comprehension in Slovak speaking patients with Parkinson´s disease

Aim: To map the sentence comprehension in Slovak speaking patients with Parkinson´s disease (PD). Method: We assessed the comprehension of reversible sentences (sentences in which the participants of the action can change their roles) with the Test of sentence comprehension and cognitive functions with standard neuropsychological battery. Sample: 37 patients with idiopathic PD and 37 healthy controls participated in the research. Groups did not differ regarding the age, education and sex. The diagnosis in patients was established by a neurologist. Results: The statistical comparison of data by Mann-Whitney U test revealed, that patients reached significantly lower score only in one out of six sentence types (p=0,016), namely in comprehension of center-embedded object relative clauses (e.g. Mother, which the daughter kissed, has the light dress.). They were significantly worse also in decoding sentences with non-canonical order of thematic roles (first patient, then agent; p=0,013). Significant correlations of individual syntactic constructions appeared with three tests: Rey Complex Figure Test, Semantic fluency and Letter-Number sequencing. Conclusion : According to our results, there are sentence comprehension deficits in Slovak speaking patients with PD, while sentence comprehension ability is correlated with cognitive test performance.
Preliminary results from a phase 1 trial of M7824 (MSB0011359C), a bifunctional fusion protein targeting PD-L1 and TGF-β, in advanced solid tumors.

3006Background: M7824 (MSB0011359C) is a novel bifunctional fusion protein comprised of a fully human IgG1 monoclonal antibody against programmed death ligand 1 (PD-L1) fused to the soluble extracellular domain of transforming growth factor-β (TGF-β) receptor II, which acts as a TGF-β trap. We report preliminary data from a phase 1 trial of M7824 in patients (pts) with advanced solid tumors. Methods: NCT02517398 is a phase 1, open-label, 3+3 dose-escalation study. Eligible pts receive M7824 at 1, 3, 10, or 20 mg/kg Q2W until confirmed progressive disease, unacceptable toxicity, or trial withdrawal; treatment beyond progression is generally allowable. The primary objective is to determine the safety and maximum tolerated dose of M7824; secondary objectives include pharmacokinetics (PK), immunogenicity, and best overall response per RECIST v1.1. Results: 16 heavily pretreated pts with ECOG performance status 0-1 have received M7824. Our PK data show a dose-linear increase in exposure starting at a dose of 3.
Target of Rapamycin: function in abiotic stress tolerance in Arabidopsis and its involvement in a possible cross-talk with ribosomal proteins

The Target of Rapamycin (TOR) protein kinase reprograms cellular metabolism under various environmental stresses. The overexpression of TOR in Arabidopsis resulted in increased plant growth including yield and biomass when compared with the wild type under both controlled and limited water conditions. In the present investigation, we report that Arabidopsis plants overexpressing TOR exhibited enhanced tolerance to the osmotic and salt stress treatments. Further to determine the role of TOR in abiotic stresses other than water limiting conditions, which were observed earlier in rice, we have treated high and medium TOR expressing Arabidopsis plants, ATR-1.4. 27 and ATR-3.7. 32 respectively, with stress-inducing chemical agents such as Mannitol (100 mM), NaCl (150 mM), Sorbitol (200 mM) and PEG (7%). Both the lines, ATR-1.4. 27 and ATR-3.7. 32 exhibited enhanced tolerance to these stresses. These lines also had increased proline and total chlorophyll contents under stress conditions compared with their corresponding WT counterparts. The upregulation of several osmotic stress inducible genes in Arabidopsis transgenic lines indicated the role of TOR in modulating multi-stress tolerance. In the present investigation, we have also analyzed the transcriptional upregulation of ribosomal protein large and small subunit (RPL and RPS) genes in AtTOR overexpressing rice transgenic lines, TR-2.24 and TR-15.1 generated earlier (Bakshi et al., 2017a), which indicated that TOR also positively regulates the transcription of ribosomal proteins (RP) along with the synthesis of rRNAs. Also, the observations from phosphoproteomic analysis in SALK lines of various Arabidopsis T-DNA insertion mutants of ribosomal proteins showed differential regulation in phosphorylation of p70kDa ribosomal protein S6K1 and comparative analysis of phosphorylation sites for RSK (Ribosomal S6 Kinases) in RPL6, RPL18, RPL23, RPL24 and RPS28C proteins of Arabidopsis, Interestingly, rice showed similarity in their peptide sequences and Ser/Thr positions. These results suggest that the phosphorylation of S6K1 is controlled by loss/ inhibition of ribosomal protein function to switch ‘on’/ ‘off’ the translational regulation for balanced growth and the pathways of both RPs and TOR are interlinked in a cyclic manner via phosphorylation of S6K1 as a modulatory step.
Suicide among justice-involved veterans: a brief overview of extant research, theoretical conceptualization, and recommendations for future research

ABSTRACT Both justice-involved individuals and veterans are at elevated risk for suicide. Despite this, research examining the intersection between justice involvement and veteran status has been limited. In addition, factors which drive risk for suicidal self-directed violence (i.e. suicide attempt, suicide) among justice-involved veterans remain understudied. This paper serves as a brief overview of extant literature regarding potential psychosocial factors which may drive suicide risk in this population. Additionally, the Interpersonal-Psychological Theory of Suicide is applied to posit specific factors underlying justice-involved veterans’ risk for suicidal self-directed violence. Finally, given the limited suicide-focused research specific to justice-involved veterans, we propose specific directions that are needed for subsequent research. In particular, further examination of a conceptual model of suicide risk in this population, as well as methods for intervening on identified risk factors, remain necessary to effectively prevent suicide in this understudied population of veterans.