Miracle-dz/UniFAR-FTUs huggingface dataset:
Efetividade da propaganda na comunicação de marcas com diferentes graus de funcionalidade e simbolismo

Esta pesquisa discute como as dimensoes de marca (funcional e simbolica) interferem na comunicacao de atributos do produto (intrinseco e extrinseco) para a obtencao de uma propaganda mais efetiva. Para tanto, foi realizado um experimento laboratorial com cenarios hipoteticos. A metodologia utilizada incluiu entrevistas com publicitarios, criacao de anuncios publicitarios e aplicacao de questionario a alunos de graduacao do curso de Administracao de uma importante universidade brasileira. Os dados foram analisados por meio de frequencias, comparacao de medias e graficos, medida de distância e proximidade, t-test e regressao logistica. Os resultados indicam que produtos com altos graus de funcionalidade e simbolismo produzem anuncios mais efetivos quando se focalizam atributos predominantemente intrinsecos. O mesmo ocorre com produtos que tem alto grau de funcionalidade e baixo simbolismo. Em ambas as situacoes os atributos extrinsecos tambem merecem atencao. Para produtos com baixa funcionalidade e alto simbolismo, por sua vez, os atributos extrinsecos devem ser principalmente comunicados. As implicacoes gerenciais merecem reflexao, nao para aplicacao direta, mas como uma ferramenta informacional a mais na producao de insights para uma maior efetividade da propaganda.
Health professionals rarely record history of complementary and alternative medicines.

AIMS To identify the completeness of documentation of Complementary And Alternative Medicine (CAM) use in hospital medical records of patients before and after an education programme. METHODS Documentation of CAM in all parts of the medical records was compared to patients' self-reported use. Data were collected for one month before and one month after an education programme for hospital staff. RESULTS At baseline: 59 (58%) of 101 patients used 129 CAM in the month prior to admission; only 36 (28%) of the CAM were documented in the medical record. After education: 51 (54%) of 94 patients used 91 CAM in the month prior to admission; 40 (44%) of the CAM were documented in the medical record. After education, recording rates increased by 16% (95% CI: 3% to 29%) due to improvements by pharmacists (18%, 95% CI: 5% to 31%). 32 (54%) of CAM users at baseline and 29 (57%) of CAM users after education informed a health professional. The recording rates were only 23 (39%) and 28 (55%) respectively for patients in these two sub-groups, being an improvement of 16% (95% CI: -2% to 34%). CONCLUSIONS Prevalence of CAM use among patients admitted to hospital is high, but documentation of usage is low. Strategies need to be designed to improve health professionals' knowledge about the need to record history of CAM use.
Mutational analysis of the Bordetella pertussis fim/fha gene cluster: identification of a gene with sequence similarities to haemolysin accessory genes involved in export of FHA

The chromosome of Bordetella pertussis harbours a region of 27 contiguous kb, which contains the bvg, fha and flm genes, involved in the co‐ordinate regulation of virulence genes, FHA production and fimbriae production, respectively. The linkage of FHA and fimbrial genes has resulted in some confusion concerning the existence and location of genes required for the production of FHA and the function of the fimbrial genes fimB‐D, which were proposed to be involved in both FHA and fimbriae biosynthesis. Through the use of non‐polar mutations in each of these genes, we found that fimB‐D are required for the production of both serotype 2 and 3 fimbriae, but not for FHA biosynthesis. Furthermore, a large open reading frame, designated fhaC, was identified downstream of fimD. It was shown that fhaC is essential for FHA production but not for fimbriae biogenesis. We propose that insertion mutations in fimB‐D affect FHA production because of polar effects on fhaC expression. An insertion in the region downstream of fhaC had only a slight effect on FHA and fimbriae production. The fhaC gene product shows homology with ShIB and HpmB, two outer membrane proteins involved in export and activation of the haemolysins, ShIA and HpmA, of Serratia marcescens and Proteus mirabilis, respectively. Homology is also observed between the N‐termini of FHA, ShIA and HpmA. Export of the haemolysins requires the Af‐termini of these molecules, and when this region was removed from FHA by an in‐frame deletion, FHA biosynthesis was abolished. These results suggest that the N‐terminus of FHA interacts with FhaC, and that as a result FHA is transported across the outer membrane.
A probabilistic trajectory synthesis system for synthesising visual speech

We describe an unsupervised probabilistic approach for synthesising visual speech from audio. Acoustic features representing a training corpus are clustered and the probability density function (PDF) of each cluster is modelled as a Gaussian mixture model (GMM). A visual target in the form of a short-term parameter trajectory is generated for each cluster. Synthesis involves combining the cluster targets based on the likelihood of novel acoustic feature vectors, then cross-blending neighbouring regions of the synthesised short-term trajectories. The advantage of our approach is coarticulation effects are explicitly captured by the mapping. The inﬂuence of cluster targets naturally increase and decrease with the likelihood of the acoustic feature vectors.
MetaCoMET: a web platform for discovery and visualization of the core microbiome

MOTIVATION A key component of the analysis of microbiome datasets is the identification of OTUs shared between multiple experimental conditions, commonly referred to as the core microbiome. RESULTS We present a web platform named MetaCoMET that enables the discovery and visualization of the core microbiome and provides a comparison of the relative abundance and diversity patterns between subsets of samples within a microbiome dataset. MetaCoMET provides an efficient and interactive graphical interface for analyzing each subset defined by the union or disjunction of groups within the Venn diagram, and includes a graphical taxonomy summary, alpha diversity metrics, Principal Coordinate analysis, abundance-based heatmaps, and a chart indicating the geographic distribution of each sample. AVAILABILITY AND IMPLEMENTATION MetaCoMET is a user-friendly and efficient web platform freely accessible at http://probes.pw. usda.gov/MetaCoMET or http://aegilops.wheat. ucdavis.edu/MetaCoMET CONTACT: devin.coleman-derr@ars.usda.govSupplementary information: Supplementary data are available at Bioinformatics online.
A SAN LORENZO PHASE HOUSEHOLD ASSEMBLAGE FROM EL REMOLINO, VERACRUZ

Abstract While scholars actively search for material and symbolic indications of Olmec influence outside the Gulf Coast, few have taken a close look at the variation and intricacies of Early Formative period material culture within the Gulf Coast region. The increasing body of data on houses in the Olmec heartland is beginning to allow comparisons and new kinds of analyses not previously possible in Olmec studies. Excavated materials from San Lorenzo phase (1200–900 b.c., radiocarbon years; 1400–1000 b.c.) households at El Remolino in the San Lorenzo region are analyzed in a preliminary attempt to evaluate the particulars of a San Lorenzo Olmec domestic assemblage in order to provide a baseline for future research. I compare quantities of different artifact classes, vessel forms, vessel orifice diameters, and pottery decoration to arrive at an understanding of a modest Olmec household inventory. Through this analysis, I argue that several of the San Lorenzo horizon markers cited as evidence of Olmec influence or migration elsewhere in Mesoamerica are quite rare in the Olmec heartland itself. Both Calzadas Carved and Limón Carved-Incised pottery decorations1 occur only in minute quantities (<1%) in the Remolino (and San Lorenzo) assemblage, and hollow white-ware figurines are entirely absent at this nonelite context. Except for its location 5 km from San Lorenzo, El Remolino would not qualify as an Olmec site based on the lack of artifact markers emphasized by archaeologists working outside of the Gulf Coast. I argue that we need a better idea of the range of Gulf Coast Olmec variation before we delve too far into discussions of Gulf Coast influence.
Shape matching utilizing indexed hypotheses generation and testing

The authors develop an indexing mechanism, which is part of an overall scheme called SMITH (shape matching utilizing indexed hypothesis generation and testing) for 2-D model-based object recognition. Their approach is based on a dynamic programming implementation of attributed string matching, is computationally efficient, and works effectively for both nonoccluded as well as occluded shapes. Another advantage of this technique is that models may be inerted or deleted with relatively little cost. >
Novel Tripartite Aromatic Acid Transporter Essential for Terephthalate Uptake in Comamonas sp. Strain E6

ABSTRACT It has been suggested that a novel type of aromatic acid transporter, which is similar to the tripartite tricarboxylate transporter (TTT), is involved in terephthalate (TPA) uptake by Comamonas sp. strain E6. This suggestion was based on the presence of the putative TPA-binding protein gene, tphC, in the TPA catabolic operon. The tphC gene is essential for growth on TPA and is similar to the genes encoding TTT-like substrate-binding proteins. Here we identified two sets of E6 genes, tctBA and tpiBA, which encode TTT-like cytoplasmic transmembrane proteins. Disruption of tctA showed no influence on TPA uptake but resulted in a complete loss of the uptake of citrate. This loss suggests that tctA is involved in citrate uptake. On the other hand, disruption of tpiA or tpiB demonstrated that both genes are essential for TPA uptake. Only when both tphC and tpiBA were introduced with the TPA catabolic genes into cells of a non-TPA-degrading Pseudomonas strain did the resting cells of the transformant acquire the ability to convert TPA. From all these results, it was concluded that the TPA uptake system consists of the TpiA-TpiB membrane components and TPA-binding TphC. Interestingly, not only was the tpiA mutant of E6 unable to grow on TPA or isophthalate, it also showed significant growth delays on o-phthalate and protocatechuate. These results suggested that the TpiA-TpiB membrane components are able to interact with multiple substrate-binding proteins. The tpiBA genes were constitutively transcribed as a single operon in E6 cells, whereas the transcription of tphC was positively regulated by TphR. TPA uptake by E6 cells was completely inhibited by a protonophore, carbonyl cyanide m-chlorophenyl hydrazone, indicating that the TPA uptake system requires a proton motive force.
Moving Away from Silicon: The Role of Interconnect in New Memory Technologies

New non-volatile memory concepts are based on non-Si materials, enabling new cell integration schemes. Memory elements are integrated in-between the first interconnect layers for realizing smaller cell sizes. New rectifying materials allow full decoupling from the substrate and 3-D stacking of cross-point memory arrays, moving more functionality into the back-end, and changing the role of interconnect from a passive to an active network. 3-D stacking is also pursued for Si-based memories using multiple active Si layers, with new contact technology challenges.
Is a Robot Better than Video for Initiating Remote Social Connections Among Children?

To investigate how children interact differently when interactions are mediated with screen-based video communication versus a robot-mediated communication, we conducted a study with elementary students in Korea, comparing the use of both technologies to introduce classroom students with peer-aged individuals in America. Our findings show that the classroom children showed more positive emotion during certain tasks and exhibited more interest to remote participants in the context of robotmediated communication than with video-mediated communication. Categories and Subject Descriptors H.4. 3 Communications Applications: Computer conferencing,teleconferencing, and videoconferencingGeneral TermsHuman Factors, Languages.
James Reid Moir, 1879 - 1944

In October 1910, Mr J. Reid Moir, who then assisted his father in the management of a tailor’s and outfitter’s business in the Throughfare (Butter Market) of Ipswich, broke into print by addressing a letter to The Times. The letter duly appeared in the issue of 17 October, side by side with one which was concerned with the revision of the Prayer Book. In his letter Reid Moir challenged the beliefs then prevalent, viz.—that man first arrived in England in post-glacial times; that the flint axes found in valley gravels, represented the earliest tools of man. The arrival of man in England, he affirmed, had taken place before the ancient Crag deposits of East Anglia had been laid down, for from the ‘Bone Bed’ which underlies them he had, at several sites, extracted flints which showed evidence of having been shaped into implements by human hands. Secondly, he maintained that the implements he had found under the Crag were the ancestral forms from which the hand-axes of the valley gravels had been evolved. Thirdly, he maintained that the Sub-Crag implements were the work, not of beginners, but of men who had already attained a degree of skill, and that there must be still older forms which would link them to the Eoliths found by Benjamin Harrison on the Kentish plateau in 1885. The letter was couched in terms which showed the writer was certain of his facts and had full confidence in himself. The greater part of Reid Moir’s life was spent in searching the formations of East Anglia for evidence of man’s presence in them. Geologists had unravelled their history before Reid Moir touched them; but it was he more than any one else who made them pages of human history. Reid Moir humanized the Crag deposits; that, in brief, seems to me to summarize his contribution to knowledge.
Ontology Concept Similarity in Semantic Query

Ontology is increasingly being used to build applications that utilize domain-specific knowledge. How to process ontology-based query efficiently has received many attentions in resent research. The measurement of concept's similarity is basis and foundation of semantic query based on ontology, however, current similarity measurement of ontology concepts involves in artificial intelligence area and psychological area limit efficiency when facing the application that the information is complicated, we propose a model to measure the semantic similarity between concepts on the basis of psychological studies about similarity and artificial intelligence studies about similarity, we express how to implement semantic query. Our approach enables users to reference ontology data directly from SQL using the semantic query operators, and make the ontology-driven applications easy to develop.
Distributed flocking control and obstacle avoidance for multi-agent systems

This paper deals with the distributed flocking control problem of multiple agents with the leader-follower structure. By using smooth time-varying feedback control approach and consensus theory, a set of distributed formation control laws is designed, which can achieve stable flocking motion of a system of multiple agents. Moreover, the potential functions with the function of both obstacle avoidance and collisions between the agents are also constructed. Finally, all the followers could arrive at the destination by following the leader while successfully negotiate the obstacles in the environment. Finally, simulation results verify the validity of the proposed control laws.
Dosing patterns of aripiprazole and quetiapine for adjunctive treatment of major depressive disorder (2006–2010)

The aim of this study was to investigate the dosing patterns of adjunctive quetiapine or adjunctive aripiprazole in the treatment of major depressive disorder from 2006 to 2010, and to evaluate the impact of Food and Drug Administration (FDA) approval on these dosing patterns. Patients included in the study were adults diagnosed with major depressive disorder, and treated with adjunctive aripiprazole or quetiapine between the years 2006 and 2010. The average daily dose and dose distribution were calculated and assessed statistically over the same time period. The mean daily dose for patients treated with adjunctive aripiprazole decreased from 13.5 mg/day in 2006 to 6.9 mg/day in 2010, whereas the mean daily dose for patients treated with quetiapine increased from 129 mg/day in 2006 to 139 mg/day in 2007, decreasing to 123 mg/day in 2010. The proportion of patients receiving FDA-recommended doses increased significantly for aripiprazole (86.3% in 2006 to 94.5% in 2010; P<0.001) and remained relatively stable for quetiapine (21.3% in 2006 to 24.0% in 2010; NS). The majority of patients treated with quetiapine received doses below those recommended by the FDA throughout the study period. Aripiprazole was mostly prescribed at therapeutic doses (pre-FDA and post-FDA approval), although the mean dose decreased significantly over time.
Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program

Infection of cells with herpes simplex virus type 1 (HSV-1) results in a rapid alteration of phosphorylation on the large subunit of cellular RNA polymerase II (RNAP II), most likely on its C-terminal domain (S. A. Rice, M. C. Long, V. Lam, C. A. Spencer, J. Virol. 68:988-1001, 1994). This phosphorylation modification generates a novel form of the large subunit which we have designed IIi. In this study, we examine roles that HSV-1 gene products play in this process. An HSV-1 mutant defective in the immediate-early transcriptional activator protein ICP4 is able to efficiently induce IIi. Viruses having mutations in the genes for the ICP0, ICP6, or ICP27 proteins are also competent for IIi formation. In contrast, 22/n199, an HSV-1 mutant which contains a nonsense mutation in the gene encoding the immediate-early protein ICP22, is significantly deficient in IIi induction. This effect is seen in Vero cells, where 22/n199 grows relatively efficiently, and in human embryonic lung (HEL) cells, where 22/n199 growth in more restricted. RNAP II is recruited into viral replication compartments in 22/n199-infected cells, indicating that altered phosphorylation of RNAP II is not a prerequisite for nuclear relocalization of RNAP II. In addition, we show by nuclear run-on transcription analysis that viral gene transcription is deficient in HEL cells infected with 22/n199. Viral late gene transcription does not occur efficiently, and antisense transcription throughout the genome is diminished compared with that of the wild-type HSV-1 infection. These transcriptional effects cannot be explained by differences in viral DNA replication, since 22/n199 replicates its DNA efficiently in HEL cells. Our results demonstrated that ICP22 is necessary for virus-induced aberrant phosphorylation of RNAP II and for normal patterns of viral gene transcription in certain cell lines.
Fatty acid composition, including conjugated linoleic acid, of intramuscular fat from steers offered grazed grass, grass silage, or concentrate-based diets.

The effects of grazed grass, grass silage, or concentrates on fatty acid composition and conjugated linoleic acid (cis-9, trans-11-18:2; CLA) concentrations of i.m. fat of steers fed to achieve similar carcass growth rates were investigated. Fifty steers were divided into 10 blocks based on body weight and assigned at random from within blocks to one of five dietary treatments. The experimental rations offered daily for 85 d preceding slaughter were 1) grass silage for ad libitum intake plus 4 kg of concentrate, 2) 8 kg of concentrate plus 1 kg of hay, 3) 6 kg of grazed grass DM plus 5 kg of concentrate, 4) 12 kg of grazed grass DM plus 2.5 kg concentrate, or 5) 22 kg of grazed grass DM. The concentration of polyunsaturated fatty acids (PUFA) in i.m. fat was higher (P < .05) for steers offered ration 5 than for those given any other ration. Decreasing the proportion of concentrate in the diet, which effectively increased grass intake, caused a linear decrease in the concentration of i.m. saturated fatty acids (SFA) (P < .01) and in the n-6:n-3 PUFA ratio (P < .001) and a linear increase in the PUFA:SFA ratio (P < .01) and the conjugated linoleic acid concentration (P < .001). The data indicate that i.m. fatty acid composition of beef can be improved from a human health perspective by inclusion of grass in the diet.
Coordinated Zinc Homeostasis Is Essential for the Wild-Type Virulence of Brucella abortus

ABSTRACT Metal homeostasis in bacterial cells is a highly regulated process requiring intricately coordinated import and export, as well as precise sensing of intracellular metal concentrations. The uptake of zinc (Zn) has been linked to the virulence of Brucella abortus; however, the capacity of Brucella strains to sense Zn levels and subsequently coordinate Zn homeostasis has not been described. Here, we show that expression of the genes encoding the zinc uptake system ZnuABC is negatively regulated by the Zn-sensing Fur family transcriptional regulator, Zur, by direct interactions between Zur and the promoter region of znuABC. Moreover, the MerR-type regulator, ZntR, controls the expression of the gene encoding the Zn exporter ZntA by binding directly to its promoter. Deletion of zur or zntR alone did not result in increased zinc toxicity in the corresponding mutants; however, deletion of zntA led to increased sensitivity to Zn but not to other metals, such as Cu and Ni, suggesting that ZntA is a Zn-specific exporter. Strikingly, deletion of zntR resulted in significant attenuation of B. abortus in a mouse model of chronic infection, and subsequent experiments revealed that overexpression of zntA in the zntR mutant is the molecular basis for its decreased virulence. IMPORTANCE The importance of zinc uptake for Brucella pathogenesis has been demonstrated previously, but to date, there has been no description of how overall zinc homeostasis is maintained and genetically controlled in the brucellae. The present work defines the predominant zinc export system, as well as the key genetic regulators of both zinc uptake and export in Brucella abortus. Moreover, the data show the importance of precise coordination of the zinc homeostasis systems as disregulation of some elements of these systems leads to the attenuation of Brucella virulence in a mouse model. Overall, this study advances our understanding of the essential role of zinc in the pathogenesis of intracellular bacteria.
Relação entre o condicionamento físico e a idade no desempenho de equipes de corrida de aventura

O objetivo deste estudo foi correlacionar valores de consumo maximo deoxigenio (VO2max) e variaveis avaliadas no segundo limiar ventilatorio (2oLV) de equipesde Corrida de Aventura. Seis equipes realizaram teste progressivo em esteira paradeterminacao do VO2max e do 2oLV. Nao foram encontradas diferencas significativas entreas medias das equipes e sua correlacao com o desempenho foi baixa. Bons coeficientesforam encontrados entre idade e desempenho para navegadores (r =-0,77) e mulheres(r = -0,90; p<0,05). Apesar do condicionamento fisico ser requisito ao esporte, a experienciados navegadores e da mulher pode ter contribuido para o desempenho das equipes.
Reconnecting Cognitive Neuropsychology: Commentary on Harley's 'Does Cognitive Neuropsychology have a Future?'.

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