Miracle-dz/UniFAR-FTUs huggingface dataset:
Left Atrial Appendage Thrombus Formation in a Patient on Dabigatran Therapy Associated With ABCB1 and CES-1 Genetic Defect

Dabigatran, directly targeting thrombin, is widely used for the prevention of stroke in nonvalvular atrial fibrillation (NVAF). We reported a rare case of left atrial appendage thrombus formation in a persistent NVAF patient despite the 31 months uninterrupted treatment with dabigatran 110 mg twice daily. The patient is a carrier of ABCB1 variant alleles with 7 heterozygote single nucleotide polymorphisms (SNPs: rs4148738, rs2235046, rs1128503, rs10276036, rs1202169, rs1202168, rs1202167) as well as CES-1 variant alleles with 2 homozygote SNPs (rs2244613 and rs4122238) and 2 heterozygote SNPs (rs8192935 and rs4580160), which may contribute to the changes of dabigatran plasma concentration. In addition, Drug-drug interaction with atorvastatin may also play a role to decrease dabigatran plasma concentration. There are only four such cases till date, of which had thrombus in the left atrium, reported in the literature. We firstly reported the documented case in a Chinese patient carrying multiple alleles of ABCB1 and CES-1, who suffered from thrombus in the left atrial appendage despite long-term anticoagulation with dabigatran. More clinical data are required to elucidate the impact of CES-1 and ABCB1 polymorphism on dabigatran pharmacokinetics, especially for Asian.
Herpes Zoster Infection in Patients With Ulcerative Colitis Receiving Tofacitinib

Abstract Background Tofacitinib is an oral, small molecule Janus kinase inhibitor that is being investigated for ulcerative colitis (UC). Tofacitinib is approved for rheumatoid arthritis and psoriatic arthritis, where it has been shown to increase herpes zoster (HZ) risk. We evaluated HZ risk among UC patients using tofacitinib. Methods HZ cases were identified in tofacitinib phase II/III/ongoing, open-label, long-term extension (OLE) UC trials. We calculated HZ incidence rates (IRs) per 100 patient-years of tofacitinib exposure within phase III maintenance (Maintenance Cohort) and phase II/III/OLE (Overall Cohort) studies, stratified by baseline demographics and other factors. HZ risk factors were evaluated in the Overall Cohort using Cox proportional hazard models. Results Overall, 65 (5.6%) patients developed HZ. Eleven patients had multidermatomal involvement (2 nonadjacent or 3–6 adjacent dermatomes), and 1 developed encephalitis (resolved upon standard treatment). Five (7.7%) events led to treatment discontinuation. HZ IR (95% confidence interval [CI]) in the Overall Cohort was 4.07 (3.14–5.19) over a mean (range) of 509.1 (1–1606) days, with no increased risk observed with increasing tofacitinib exposure. IRs (95% CI) were highest in patients age ≥65 years, 9.55 (4.77–17.08); Asian patients, 6.49 (3.55–10.89); patients with prior tumor necrosis factor inhibitor (TNFi) failure, 5.38 (3.86–7.29); and patients using tofacitinib 10 mg twice daily, 4.25 (3.18–5.56). Multivariate analysis identified older age and prior TNFi failure as independent risk factors. Conclusions In tofacitinib-treated UC patients, there was an elevated risk of HZ, although complicated HZ was infrequent. Increased HZ rates occurred in patients who were older, Asian, or had prior TNFi failure (NCT00787202, NCT01465763, NCT01458951, NCT01458574, NCT01470612).
Self organizing software defined edge controller in IoT infrastructure

As the number of IoT devices are rapidly increasing and a huge number of access layer devices are underutilized, we propose a self organized software defined edge controller in internet of things (IoT) infrastructure. Our proposed controller gathers information about all the available resources and learns the parameters for serving an IoT node in such a way that the total service time for nodes in the system minimizes. Two methods, round robin and mean time to complete, are utilized for redirecting requests to the resources. MATLAB and mininet simulation results show the self organizing capability of the proposed system.
Gastric adenocarcinoma expressing human epidermal growth factor receptor in South Asian population

Background/Aim: Gastric cancer is the third leading cause of cancer mortality worldwide. Human epidermal growth factor (Her-2/neu) has shown strong therapeutic implication in breast cancer. Although the prevalence of Her-2/neu over-expression in gastric cancer has been reported across the world, it is still unknown from South Asia. The aim of this study is to evaluate Her-2/neu expression in gastric adenocarcinomas and to correlate with various clinicopathological variables. Patients and Methods: A total of 95 consecutive patients undergoing endoscopic biopsy or gastrectomy were recruited in this study. Clinicopathological parameters of all patients were recorded and hematoxylin and eosin (H and E) staining was performed. Over-expression of Her-2/neu was investigated by immunohistochemistry using α-Her-2 antibody. To quantify Her-2/neu over-expression, the Hofmann validation scoring system was used and further its association was seen with age, gender, histopathological type, grade, and stage of the tumor. Data were entered and analyzed using SPSS version 21. A P value of <0.05 was considered as significant. Results: Overall, 21 (22.1%) cases were positive for Her-2/neu overexpression from the total of 95 gastric adenocarcinomas. Her-2/neu was significantly expressed in low-grade gastric cancer (grade I = 50%, grade II = 34.5%, grade III = 14.5%; P = 0.030). Although there was insignificant difference between Her-2/neu over expression and other variables, Her-2/neu score 3+ was predominantly seen in females, age >60 years, Laurens intestinal type, and IIIC stage tumors. Conclusion: Her-2/neu is over-expressed in a limited group of gastric cancer patients in our population and indicates a significant strong association with low grades of gastric cancer.
Microclimate and Individual Variation in Pollinators: Flowering Plants are More than Their Flowers

Variation in pollinator composition at the individual plant level is an im- portant prerequisite for plant specialization on pollinators that does not seem to have been investigated previously. I studied variation in pollinator composition in a southeastern Spanish population of the insect-pollinated shrub Lavandula latifolia (Labiatae) and ex- amined its correlates, with particular reference to the distinction between factors intrinsic (flower morphology, nectar standing crop, size of floral display) and extrinsic (sunlight regime, ambient temperature, humidity) to the plants. L. latifolia shrubs differed signifi- cantly in all intrinsic variables measured, in average irradiance levels (due to site-dependent variation in timing and duration of insolation periods), and in pollinator composition at both the species and order levels. Individual variation in pollinator composition was largely due to differences among insect taxa in their foraging responses to the sunlight mosaic. While some pollinators foraged indiscriminately over that mosaic, others preferred sites characterized by high irradiance. Variation among plants in intrinsic variables was unrelated to differences in pollinator composition, which depended significantly only on the sunlight regime associated with each plant's location in the habitat. Site-specific effects in pollination will generally act to reduce the likelihood of selective pressures by animals on plant traits. Their importance should be greatest in habitats characterized by patchiness in environmental variables that affect pollinator behavior and in plants with pollinator assemblages dominated by ectothermic species.
Description of the chimaerid jaw and its phylogenetic origins

Anatomical delineation of the holocephalan palatoquadrate has proven to be difficult and, so, has been an extensively debated topic as it relates to the evolutionary derivation of jaws, modes of jaw suspension, and the interrelationships of the hondrichthyes (Elasmobranchii and Holocephali). Embryological analyses of the chimaerid jaw and cranium are presented to provide an anatomical description of the palatoquadrate in modern chimaerids. The palatoquadrate fuses, anteriorly, to the nasal capsule early in development. This marks the first point of contact between the mandibular arch and cranium. Orbitonasal canal foramina delineate the dorsal palatoquadrate margin. The posteriormost margin is marked by fusion of the upper jaw with trabecular and parachordal cartilages in the region of the efferent eudobranchial artery foramen and by a suborbitally positioned basitrabecular cartilage. This basitrabecula generates a subocular shelf as it fuses medially to the parachordal cartilage and posteriorly to the postorbital wall and cranial otic process.
The 10 Vs, Issues and Challenges of Big Data

In this emerging computing and digital globe, information and Knowledge are created and then collected with a rapid approach by wide range of applications through scientific computing and commercial workloads. Over 3.8 billion people out of 7.6 billion population of the world are connected to the internet. Out of 13.4 billion devices, 8.06 billion devices have a mobile connection. In 2020, 38.5 billion devices will be connected and globally internet traffic will be 92 times greater than it was in 2005. The use of such devices and internet not only increase the data volume but the velocity of market brings in fast-track and accelerates as information is transferred and shared with light speed on optic fiber and wireless networks. This fast generation of huge data creates numerous challenges. The existing approaches addressing issues such as, Volume, Variety, Velocity and Value in big data research perspective. The objectives of the paper are to investigate and analyze the current status of Big Data and furthermore a comprehensive overview of various aspects has discussed, and additionally has been described all 10 Vs' (Issues) of Big Data.
Feeding behavior and trophic interaction of three shark species in the Galapagos Marine Reserve

There is great concern about the future of sharks in Ecuador because of the lack of biological knowledge of most species that inhabit the region. This paper analyzes the feeding behavior of the pelagic thresher shark (Alopias pelagicus), the blue shark (Prionace glauca) and the silky shark (Carcharhinus falciformis) through the use of stable isotopes of carbon and nitrogen (δ13C and δ15N), with the aim of determining the degree of interaction between these species in the Galapagos Marine Reserve. No interspecific differences were found in use of oceanic vs. inshore feeding areas (δ13C: Kruskal–Wallis test, p = 0.09). The position in the hierarchy of the food web where A. pelagicus feeds differed from that of the other species (δ15N: Kruskal–Wallis test, p = 0.01). There were no significant differences in δ13C and δ15N values between males and females of the three species (Student’s t-test, p > 0.05), which suggests that both sexes have a similar feeding behavior. A specialist strategy was observed in P. glauca (trophic niche breadth TNB = 0.69), while the other species were found to be generalist (A. pelagicus TNB = 1.50 and C. falciformis TNB = 1.09). The estimated trophic level (TL) varied between the three species. C. falciformis occupied the highest trophic level (TL = 4.4), making it a quaternary predator in the region. The results of this study coincide with the identified behavior in these predators in other areas of the tropical Pacific (Colombia and Mexico), and suggest a pelagic foraging strategy with differential consumption of prey between the three species. These ecological aspects can provide timely information when implementing in conservation measures for these shark species in the Tropical Pacific and Galapagos Marine Reserve.
Hamstring-to-Quadriceps Torque Ratios of Professional Male Soccer Players: A Systematic Review.

Baroni, BM, Ruas, CV, Ribeiro-Alvares, JB, and Pinto, RS. Hamstring-to-quadriceps torque ratios of professional male soccer players: A systematic review. J Strength Cond Res XX(X): 000-000, 2018-The goal of this review was to determine the isokinetic hamstring-to-quadriceps (H/Q) torque ratios of professional male soccer players. Systematic searches were independently carried out by 2 researchers in 7 electronic databases. Only studies with teams from the first or second national leagues were included. From these studies, we extracted the players' H/Q conventional (concentric/concentric) and/or functional (eccentric/concentric) ratios. The initial search resulted in 2,128 articles that were filtered to 30 articles (1,727 players) meeting the inclusion criteria. The H/Q conventional ratio was assessed in 27 studies (1,274 players), whereas the H/Q functional ratio was assessed in 15 studies (1,082 players). The H/Q conventional ratio mean scores of professional male soccer players were close to 60% when tested at low to intermediate angular velocities (12°·s = 52 ± 7%; 30°·s = 52 ± 8%; 60°·s = 65 ± 12%; 90°·s = 57 ± 6%; 120°·s = 65 ± 16%; 180°·s = 67 ± 17%) and around 70-80% at fast angular velocities (240°·s = 80 ± 40%; 300°·s = 70 ± 15%; 360°·s = 80 ± 13%). The H/Q functional ratio mean scores of professional male soccer players were close to 80% at 60°·s (79 ± 19%), around 100-130% at intermediate to fast angular velocities (120°·s = 127 ± 42%; 180°·s = 96 ± 19%; 240°·s = 109 ± 22%; 300°·s = 123 ± 18%), and near or above 130% when angular testing velocities were mixed (eccentric hamstring < concentric quadriceps; 30/240°·s = 132 ± 26%; 60/180°·s = 129 ± 20%; 60/240°·s = 153 ± 30%). In conclusion, considering the tested isokinetic angular velocity, professional male soccer players do not meet the traditional reference landmarks used to assess the strength balance between quadriceps and hamstring muscles (i.e., 60 and 100% for H/Q conventional and functional ratios, respectively), which supports a need for specific reference values according to the angular velocity selected for testing H/Q torque ratios.
Hygiene assessments of school kitchens based on the microbiological status of served food.

BACKGROUND According to European trends, more children eat at school canteens than ever before, therefore food safety and quality have become increasingly significant in recent years. Nevertheless, there are large differences in food safety levels in different school canteens. We hypothesize that the microbial status of the served meal represents on the general hygiene of the kitchen. Our research examines whether mesophilic aerobic bacteria measured in served food are connected with the level of hygiene in the catering unit, and whether this indicator can be used as a criterion for assessing school kitchens. METHODS Meal samples were collected from six school kitchens, and mesophilic aerobic bacterial count was measured. Samples were collected on five different days, so each kitchen was monitored five times. Two meals per visit were collected: a soup and a main course. RESULTS Out of the 60 samples, 26 were good (CFU/g < 103), 24 were acceptable (CFU/g: 103–105), and in 10 samples, the microbial count was found to be above the limit (CFU/g > 105). Statistical calculations revealed that microbial contamination of served meals was influenced neither by the supplier nor by the type of meal (soup or main course). However, the level of hygiene in the serving kitchen significantly affects the microbial status of meals. CONCLUSIONS Based on the results, a qualification system can be developed using the mesophilic aerobic bacterial count measurable in the served meal to assess hygiene. By regular determination of mesophilic aerobic bacterial count and the presence of Enterobacteriaceae, the food safety of a catering unit can be quantitatively evaluated.
Magnetocarcinogenesis: is there a mechanism for carcinogenic effects of weak magnetic fields?

Extremely low-frequency (ELF) magnetic fields have been classified as possibly carcinogenic, mainly based on rather consistent epidemiological findings suggesting a link between childhood leukaemia and 50–60 Hz magnetic fields from power lines. However, causality is not the only possible explanation for the epidemiological associations, as animal and in vitro experiments have provided only limited support for carcinogenic effects of ELF magnetic fields. Importantly, there is no generally accepted biophysical mechanism that could explain such effects. In this review, we discuss the possibility that carcinogenic effects are based on the radical pair mechanism (RPM), which seems to be involved in magnetoreception in birds and certain other animals, allowing navigation in the geomagnetic field. We review the current understanding of the RPM in magnetoreception, and discuss cryptochromes as the putative magnetosensitive molecules and their possible links to cancer-relevant biological processes. We then propose a hypothesis for explaining the link between ELF fields and childhood leukaemia, discuss the strengths and weaknesses of the current evidence, and make proposals for further research.
Curriculum Adversarial Training

Recently, deep learning has been applied to many security-sensitive applications, such as facial authentication. The existence of adversarial examples hinders such applications. The state-of-the-art result on defense shows that adversarial training can be applied to train a robust model on MNIST against adversarial examples; but it fails to achieve a high empirical worst-case accuracy on a more complex task, such as CIFAR-10 and SVHN. In our work, we propose curriculum adversarial training (CAT) to resolve this issue. The basic idea is to develop a curriculum of adversarial examples generated by attacks with a wide range of strengths. With two techniques to mitigate the catastrophic forgetting and the generalization issues, we demonstrate that CAT can improve the prior art's empirical worst-case accuracy by a large margin of 25% on CIFAR-10 and 35% on SVHN. At the same, the model's performance on non-adversarial inputs is comparable to the state-of-the-art models.
Spectroscopic analyses of the blue hook stars in NGC 2808: A more stringent test of the late hot flasher scenario

Recent UV observations of the globular cluster NGC 2808 (Brown et al. [CITE]) show a significant population of hot stars fainter than the zero-age horizontal branch (“blue hook” stars), which cannot be explained by canonical stellar evolution. Their results suggest that stars which experience unusually large mass loss on the red giant branch and which subsequently undergo the helium core flash while descending the white dwarf cooling curve could populate this region. Theory predicts that these “late hot flashers” should show higher temperatures than the hottest canonical horizontal branch stars and should have helium- and carbon-rich atmospheres. As a test of this late hot flasher scenario, we have obtained and analysed medium resolution spectra of a sample of blue hook stars in NGC 2808 to derive their atmospheric parameters. Using the same procedures, we have also re-analyzed our earlier spectra of the blue hook stars in ω Cen (Moehler et al. [CITE]) for comparison with the present results for NGC 2808. The blue hook stars in these two clusters are both hotter ($T_{\rm eff} \ge 35\,000$ K) and more helium-rich than canonical extreme horizontal branch stars in agreement with the late hot flasher scenario. Moreover, we find indications for carbon enhancement in the three most helium-enriched stars in NGC 2808. However, the blue hook stars still show some hydrogen in their atmospheres, perhaps indicating that some residual hydrogen survives a late hot flash and then later diffuses to the surface during the horizontal branch phase. We note that the presence of blue hook stars apparently depends mostly on the total mass of the globular cluster and not so much on its horizontal branch morphology.
Osteosarcopenic Visceral Obesity and Osteosarcopenic Subcutaneous Obesity, Two New Phenotypes of Sarcopenia: Prevalence, Metabolic Profile, and Risk Factors

Background The main criticism of the definition of “osteosarcopenic obesity” (OSO) is the lack of division between subcutaneous and visceral fat. This study describes the prevalence, metabolic profile, and risk factors of two new phenotypes of sarcopenia: osteosarcopenic visceral obesity (OSVAT) and osteosarcopenic subcutaneous obesity (OSSAT). Methods A standardized geriatric assessment was performed by anthropometric and biochemical measures. Dual-energy X-ray absorptiometry (DXA) was used to assess body composition, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), osteoporosis, and sarcopenia. Results A sample of 801 subjects were assessed (247 men; 554 women). The prevalence of osteosarcopenic obesity (OSO) was 6.79%; OSSAT and OSOVAT were, respectively, 2.22% and 4.56%. OSVAT (versus the others) showed a higher level of inflammation (CRP and ESR, p < 0.05), bilirubin (p < 0.05), and risk of fractures (FRAX index over 15%, p < 0.001). Subjects with OSSAT did not show any significant risk factors associated to obesity. Conclusions The osteosarcopenic visceral obesity phenotype (OSVAT) seems to be associated with a higher risk of fractures, inflammation, and a worse metabolic profile. These conditions in OSVAT cohort are associated with an increase of visceral adipose tissue, while patients with OSSAT seem to benefit related to the “obesity paradox”.
Mindfulness-based stress reduction for treating chronic headache: A systematic review and meta-analysis

Background Mindfulness-based stress reduction/cognitive therapy are frequently used for pain-related conditions, but their effects on headache remain uncertain. This review aimed to assess the efficacy and safety of mindfulness-based stress reduction/cognitive therapy in reducing the symptoms of chronic headache. Data sources and study selection MEDLINE/PubMed, Scopus, CENTRAL, and PsychINFO were searched to 16 June 2017. Randomized controlled trials comparing mindfulness-based stress reduction/cognitive therapy with usual care or active comparators for migraine and/or tension-type headache, which assessed headache frequency, duration or intensity as a primary outcome, were eligible for inclusion. Risk of bias was assessed using the Cochrane Tool. Results Five randomized controlled trials (two on tension-type headache; one on migraine; two with mixed samples) with a total of 185 participants were included. Compared to usual care, mindfulness-based stress reduction/cognitive therapy did not improve headache frequency (three randomized controlled trials; standardized mean difference = 0.00; 95% confidence interval = −0.33,0.32) or headache duration (three randomized controlled trials; standardized mean difference = −0.08; 95% confidence interval = −1.03,0.87). Similarly, no significant difference between groups was found for pain intensity (five randomized controlled trials; standardized mean difference = −0.78; 95% confidence interval = −1.72,0.16). Conclusions Due to the low number, small scale and often high or unclear risk of bias of included randomized controlled trials, the results are imprecise; this may be consistent with either an important or negligible effect. Therefore, more rigorous trials with larger sample sizes are needed.