Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular taxonomy of human ocular outflow tissues defined by single cell transcriptomics

The conventional outflow pathway is a complex tissue responsible for maintaining intraocular pressure (IOP) homeostasis. The coordinated effort of multiple cells with differing responsibilities ensure healthy outflow function and IOP maintenance. Dysfunction of one or more resident cell type results in ocular hypertension and risk for glaucoma, a leading cause of blindness. In this study, single cell RNA sequencing was performed to generate a comprehensive cell atlas of human conventional outflow tissues. We obtained 17757 genes expression profiles from 8758 cells from eight eyes of four donors representing the outflow cell transcriptome. Upon clustering analysis, 12 distinct cell types were identified, and region-specific expression of candidate genes were mapped in human tissues. Significantly, we identified two distinct expression patterns (myofibroblast and fibroblast) from cells located in the trabecular meshwork (TM), the primary structural component of the conventional outflow pathway. We also located neuron and macrophage signatures in the TM. The second primary component structure, Schlemm’s canal displayed a unique combination of lymphatic/blood vascular gene expression. Other expression clusters corresponded to cells from neighboring tissues, predominantly in the ciliary muscle/scleral spur, which together correspond to the uveoscleral outflow path. Importantly, the utility of our atlas was demonstrated by mapping glaucoma-relevant genes to outflow cell clusters. Our study provides a comprehensive molecular and cellular classification of conventional and unconventional outflow pathway structures responsible for IOP homeostasis. Significance statement Ocular hypertension is the primary, and only modifiable risk factor for glaucoma, the leading cause of irreversible blindness. Intraocular pressure is regulated homeostatically by resistance to aqueous humor outflow through an architecturally complex tissue, the conventional/trabecular pathway. In this study, we generated a comprehensive cell atlas of the human trabecular meshwork and neighboring tissues using single cell, RNA sequencing. We identified 12 distinct cell types, and mapped region-specific expression of candidate genes. The utility of our atlas was demonstrated by mapping glaucoma-relevant genes to conventional outflow cell clusters. Our study provides a comprehensive molecular and cellular classification of tissue structures responsible for intraocular pressure homeostasis in health, and dysregulation in disease.
Helicobacter pylori Infection in Healthy and Dyspeptic Adult populations Resident in Tripoli and Sabha of Libyan cities: A Seroepidemiologic Study

بكتيريا الهيليكوباكتر بلوري (بكتيريا المعدة الحلزونية) تتواجد بشكل شائع كمرض في جميع انحاء العالم وفى اكثر من نصف سكان العالم. معدل العدوى بها85-90% في الدول النامية وانتشار العدوى بهذه البكتيريا وفقا للاماكن الجغرافية و الوضع المعيشي والظروف الاقتصادية والطرق المعملية المستخدمة للكشف عنها. لا توجد معلومات حول مدى الانتشار المصلى للأجسام المضادة لبكتيريا الهيليكوباكتر بلوري لكلا من المرضى بأعراض او بدو ن ظهور اعراض للإصابة في ليبيا لذا كان هدفنا هو التحري عن مدى انتشارها بين الاصحاء والذين يعانون من عسر الهضم بين البالغين في المجتمع الليبي في كلا من مدينتي طرابلس وسبها. جمعت عينات دم (100) من اصحاء من مشفى سبها(175) من مشفى طرابلس كما جمعت ايضا عينات اخرى من الذين يعانون من عسر هضم(94و125) على التوالي لكلا المدينتين من وحدة المناظير بالمشفى وتم تحديد الايجابية من عدمها باستخدام تقنية الاليزا مع تجميع معلومات من المرضى عبر استبيان. في منطقة سبها كانت النتائج 75% موجبة بين الاصحاء 37% بين من يعانون من عسر الهضم بينما النتائج من مدينة طرابلس كانت85. 1% و 83.2%. معدل الانتشار لكلا المدينتين كان بين الفئة العمرية 35-25 سنة كما نتطلع لأجراء دراسات مستقبلية لدور هذه البكتيريا في الامراضية بقرحة المعدة والاثني عشر.
The Influence of Social-Media Sites on Job-Seeker Intentions: Facebook, Linkedin, and Twitter

Little is known about the role that company social media networking sites play in job seeker attraction. This research helps address this gap. Subjects in this study evaluated the websites of three potential employers and then selected one employer to follow on social media in subsequent weeks. Each week subjects evaluated content, the activity of the recruiter who managed each site, and the activity of other users. In addition, at the end of each week subjects evaluated the usefulness of the social networking site and reported their attitudes and intentions towards the company. The results showed no differences in job seekers’ attitudes toward the company across different companies before social media was used. Yet, after social media was used there were meaningful differences in these attitudes. Additional analysis showed that the social media forms of Facebook and Linkedin had significant influence on job seekers’ attitudes toward the company while Twitter demonstrated no such influences.
WHEN AND HOW DO CHILDREN START PRODUCING A LANGUAGE?

This article discusses how a child speaks his first language. The first language spoken through several phases is called the semantic process, syntax and phonology. Newborn babies get their first language from their mother called mother tongue. In the process, newborn babies need a lot of interaction both inside and outside the environment to obtain language, including using the five senses to find out the meaning of language acquired from the surrounding. As with animals, humans are born equipped with language acquisition devices (LAD) as the natural abilities of babies used to interpret language and learn languages. This is what distinguishes between humans and animals. By using this LAD, humans are able to communicate or respond to language from others.
Bit topology selection algorithm in design of highly accurate CMOS digital attenuator for phased array system

This paper presents a new attenuator bit topology selection algorithm for attenuator design to simultaneously achieve low amplitude and phase error with minimum insertion loss. The significance of this algorithm has been demonstrated by the design and implementation of 8-bit digital attenuator using 65 nm Complementary Metal-Oxide-Semiconductor (CMOS) technology in 2.8 GHz to 4.0 GHz frequency band. To meet the 8-bit attenuation and phase error resolution, new phase compensated Pi-, T- and T-bridge attenuator bit topologies are proposed in place of conventional attenuator bits from 32 dB to 0.25 dB. Performance of this attenuator has been validated with the help of exhaustive post layout parasitic simulation results. The integrated attenuator has demonstrated the highest ever reported attenuation precision at lowest root mean square (RMS) phase error and RMS amplitude error, i.e., 8-bit performance with maximum insertion loss of 5.1 dB, maxmum RMS phase error of 0.78° and maximum RMS amplitude error of 0.1 dB, input referred 1 dB compression point (IP1 dB) > +14.8 dBm, input and output matching <−12 dB, in 2.8 GHz to 4.0 GHz with 1.55 mm × 0.35 mm chip area. This significant improvement in the attenuation precision, RMS amplitude and phase error of the integrated attenuator is the result of, systematic design approach, selection of each attenuator bit architecture using the proposed attenuator bit selection algorithm and incorporation of phase compensation techniques.
Ontologia para o mapeamento semântico entre ambientes virtuais de aprendizagem e ambiente de aprendizagem ubíqua

Integrating heterogeneous systems requires data to be mapped in a format that can be understood by the systems involved in communication. Using ontology allows for more flexibility and semantic mapping of data. Thus, this paper aims to present the development and evaluation of an ontology for semantic mapping between virtual learning environments called LESD-Onto. An ontology was built based on the Ontology Development 101 methodology and the aspects of consistency, conclusion and conciseness. For evaluation, an ontology was used in the integration of Edubi and Moodle systems, the allowed results indicate its viability in the integration of learning systems. Resumo. Integrar sistemas heterogêneos exige que os dados sejam mapeados em um formato que possa ser compreendido pelos sistemas envolvidos na comunicação. O uso de ontologia permite mais flexibilidade e o mapeamento semântico dos dados. Desse modo, este trabalho tem como objetivo apresentar o desenvolvimento e a avaliação de uma ontologia para mapeamento semântico entre ambientes virtuais de aprendizagem chamada LESD-Onto. A ontologia foi construı́da com base na metodologia Ontology Development 101 e nos aspectos de consistência, completude e concisão. Para avaliação, a ontologia foi utilizada na integração dos sistemas Edubi e Moodle, cujos resultados dão indı́cios de sua viabilidade na integração de sistemas de aprendizagem. 1. Introdução A popularização das tecnologias digitais móveis, a valorização dos ambientes informais nas práticas educacionais e a sensibilidade ao contexto dos indivı́duos viabilizam o desenvolvimento de práticas ainda mais flexı́veis, favorecendo a aprendizagem em qualquer lugar, a qualquer momento, adequada às caracterı́sticas do indivı́duo e independente do tipo de dispositivo digital disponı́vel [Romanı́ and Moravec 2011]. Neste sentido, a aprendizagem ubı́qua (ubiquitous learning ou u-learning) surge da combinação de modelos de aprendizagem flexı́veis e tecnologias digitais com o objetivo de prover ferramentas que ampliam as oportunidades de práticas de ensino e aprendizagem. Ferramentas baseadas nesse conceito permitem oferecer aos aprendizes e proDOI: 10.5753/cbie.sbie. 2019.1761 1761 Anais do XXX Simpósio Brasileiro de Informática na Educação (SBIE 2019) VIII Congresso Brasileiro de Informática na Educação (CBIE 2019)
Eribulin in advanced urothelial cancer (AUC) patients (pts): A California Cancer Consortium trial—NCI/CTEP 7435.

4504 Background: There is an unmet need for new agents in AUC. We previously reported that eribulin, a microtubule modulator derived from black Pacific sea sponge toxin, is highly active against metastatic UC in frontline and previously treated settings (ASCO 2010; ECC 2013). Here we report composite results of 150 AUC pts treated in a single phase II trial. Methods: Eligible pts with AUC, calculated CrCl ≥ 20mL/min were treated in 3 cohorts of first line, 2nd line with or without tubulin exposure. Eribulin 1.4mg/m2 IV on d1 & 8, q3 wks. In each cohort RR > 20% considered promising; 41 pts in a Simon 2-stage design. PFS & OS were secondary endpoints. Results: Pt characteristics: Median age 68 yrs (range: 25-90); Males: 71%; KPS ≥ 90%: 57%; Transitional cell histology: 90%; Lower tract 88%, Visceral mets 67%, Bajorin risk groups: 0: 30%, 1: 61%, 2: 9%. Bajorin risk group, visceral mets +/- KPS associated with OS & PFS (p < 0.01) while renal fn, age, line of therapy & prior tubulin exposure did not. Toxicit.
Tratamiento con opioides en dolor crónico no oncológico: recomendaciones para una prescripción segura

espanolRESUMEN La prescripcion de opioides para el dolor cronico se ha incrementado en las ultimas decadas. Sin embargo, las dudas sobre su seguridad a largo plazo, un uso inadecuado y el desarrollo de conductas aberrantes asociadas a opioides (CAAO) dificultan la toma de decisiones clinicas, provocando un tratamiento insuficiente del dolor cronico. Diversas guias practicas han establecido recomendaciones para el control de los pacientes que reciben opioides a largo plazo. Cualquier medico debe conocer las herramientas disponibles para identificar a aquellos pacientes que presenten un riesgo elevado de mal uso de los opioides. Debe, ademas, saber como detectarlo y abordarlo sin comprometer el tratamiento optimo del dolor en aquellos pacientes que si pueden beneficiarse de un uso correcto de los opioides. En el presente trabajo se revisan las principales guias de practica clinica, revisiones sistematicas, recomendaciones y estrategias para minimizar los riesgos de los opioides en el tratamiento del dolor cronico no oncologico. EnglishABSTRACT Prescription of opioids for chronic pain has increased in recent decades. However, issues arise about their long-term safety, abuse and opioid-associated aberrant behaviors that hinder clinical decision-making, thereby contributing to insufficient treatment of chronic pain. Several clinical practice guidelines have established different recommendations for monitoring patients receiving long-term opioid therapies, and screening tools have been recommended to identify those at high risk. Every physician should be aware of the tools available to identify those patients requiring opioid treatment and having a high risk of addictive behaviors, knowing how to detect and treat it without compromising the optimal management of pain in those patients who can benefit from correct use of opioids. We hereby review the main clinical practice guidelines, systematic reviews, recommendations and strategies to minimize the risks of opioids in the treatment of chronic non-cancer pain.
Quantized Compressive Sampling of Stochastic Gradients for Efficient Communication in Distributed Deep Learning

In distributed training of deep models, the transmission volume of stochastic gradients (SG) imposes a bottleneck in scaling up the number of processing nodes. On the other hand, the existing methods for compression of SGs have two major drawbacks. First, due to the increase in the overall variance of the compressed SG, the hyperparameters of the learning algorithm must be readjusted to ensure the convergence of the training. Further, the convergence rate of the resulting algorithm still would be adversely affected. Second, for those approaches for which the compressed SG values are biased, there is no guarantee for the learning convergence and thus an error feedback is often required. We propose Quantized Compressive Sampling (QCS) of SG that addresses the above two issues while achieving an arbitrarily large compression gain. We introduce two variants of the algorithm: Unbiased-QCS and MMSE-QCS and show their superior performance w.r. t. other approaches. Specifically, we show that for the same number of communication bits, the convergence rate is improved by a factor of 2 relative to state of the art. Next, we propose to improve the convergence rate of the distributed training algorithm via a weighted error feedback. Specifically, we develop and analyze a method to both control the overall variance of the compressed SG and prevent the staleness of the updates. Finally, through simulations, we validate our theoretical results and establish the superior performance of the proposed SG compression in the distributed training of deep models. Our simulations also demonstrate that our proposed compression method expands substantially the region of step-size values for which the learning algorithm converges.
Movile telephony in students of physical education dependency or addiction

In this initial study on the dependency or addiction to mobile telephony in the university students of the Faculty of Educational Sciences of the University of Granada, two fundamental objectives are intended. First, establish the technical adequacy (reliability and validity) of the instrument and second, determine the degree of addiction / dependence to the mobile device that presents the sample object of investigation at a merely descriptive level. We have used a descriptive methodology per survey, responding to a sample of 60 subjects. Some of the conclusions of the work are: With regard to validity, we can affirm that the instrument claims to measure the construct for which it has been developed through the adaptation of other instruments, that is, it is creditor of content validity. It has also revealed the presence of a remarkable concurrent criterial validity that shows that the items individually measure the same as the scale in its entirety. In the second block of conclusions we highlight the fact that, in a general way, levels of dependency / addiction to the mobile device have been moderately low.
Anomaly Classification in People Counting and Occupancy Sensor Systems

People counting and occupancy sensor systems are used in diverse smart building applications like lighting controls, HVAC controls and workspace management. Anomalies in people counting and occupancy sensor data can result in undesirable application behavior. We address the problem of anomaly classification of sensor data using 3-class random forest classifiers in this work. We specifically consider sensor deployment scenarios where sensor fields-of-view may overlap. Depending on the sensor type, we devise signal features in time, frequency and spatio-temporal domains. The proposed random forest classifiers are evaluated using people counting and binary occupancy sensor data in an office environment, and are shown to have higher true positive rate and a lower false positive rate in comparison to an unsupervised ${k}$ -means method and a random forest classifier with a single signal energy feature.
A Prospective, Randomized, Double-Masked Trial Comparing Low Dose to Conventional Dose Dexamethasone in Neonatal Chronic Lung Disease

Aim: To determine if low dose dexamethasone for the treatment of chronic lung disease would be as effective as high dose with less adverse effects. Methods: A prospective, randomized, double-blinded trial of infants ≤1500 grams, ≤34 weeks, and ≤28 days of age. The high dose group received 0.5 mg/kg/d of dexamethasone for three days followed by 0.3mg/kg/d for four days. The low dose group received 0.08 mg/kg/d of dexamethasone for seven days. Results: Infants in the low and high dose groups had similar weights, gestational ages at birth, male to female ratios, and entry FiO2. The groups were similar in terms of proportion extubated during steroid course, change in FiO2, O2 requirement at 36 weeks, hospital days, ventilator days, and effect on the hypothalamic-pituitary-adrenal axis. The high dose group had significantly more patients who required treatment for hypertension and more abnormal neurodevelopmental outcomes at one year adjusted age. The high dose group also had slower weight gain, slower head growth, more patients with hyperglycemia, and a smaller mean head circumference at one year adjusted age, although these differences did not reach statistical significance. Conclusions: Compared to low dose dexamethasone, conventional dosing was associated with similar pulmonary outcomes and more adverse side effects.
Percutaneous treatment of biliary lithiasis: Indications, technical-details and complications

Poster: "ECR 2015 / C-2340 / Percutaneous treatment of biliary lithiasis: Indications, technical-details and complications" by: "S. Bonomo, G. Giordano, C. E. Tilocca, G. Failla, S. M. Santonocito, G. Petrillo, V. Magnano San Lio; Catania/IT"
An empirical study of relationships between goal alignment, centralised decision-making, commitment to networking and supply chain effectiveness using structural equation modelling

ABSTRACT The aim of this paper is to investigate the underlying factors of supply chain effectiveness of the networked organisations that are involved in the logistics industry in the UAE context. In particular, the study is to empirically test the relationships between goal alignment, commitment to networking and decision-making with four aspects of supply chain effectiveness. A questionnaire-based survey primarily inductive in nature was used to gather quantitative data from various supply chain organisations across industry verticals that are operating in the UAE. The data for this study were gathered and analysed employing survey responses from 154 representative organisations of various supply chain and logistics sector in the UAE. In this research, structural equation modelling has been applied to test these identified factors and their effect on supply chain effectiveness and its performance. The research discovered that the relationship between supply chain goal alignment, commitment to networking and decision-making were significantly and positively correlated with supply chain effectiveness. The findings provide insight into the field of supply chain effectiveness as part of supply chain performance. Several recommendations are offered for supply chain members to improve supply chain effectiveness while implementing dimensions of their strategic supply chain.
Mid-West Growing Season Weather

An earlier discussion of the summer northward heat flux at ground level at one location in northwest Iowa, based on observing the winds there over 30 consecutive summers, is extended geographically west to the Rocky Mountains and southward. Also the time-scale is stretched well past 30 years. Evidence cited is the eastward increase in plant size and greenery at constant latitude starting at the mountains, which is easily noticed from Texas to North Dakota. One dynamical element, the Coriolis force, acting on the north and south winds over long time periods helps explain the observations. Conservation of mass is another important ingredient.
HIV Risks in Sexual Networks of Heterosexual Men in South Africa

BACKGROUND: The interaction of HIV risks in sexual networks remains unclear in South Africa. We provide an overview of the dynamics of HIV risks in South African men through a systematic scoping review. METHODS & ANALYSIS: Literature searches were conducted on seven online databases. Two reviewers independently screened articles against the inclusion criteria and performed a Kappa coefficient test to evaluate the degree of agreement on article selection. Thematic content analysis and a Mixed Method Appraisal Tool version 2018 were used to present the narrative account of the outcomes and to assess the risk of bias on included studies. RESULTS: Of the 1356 records identified, six studies reported on the dynamics of HIV infection in heterosexual men in sexual networks. All studies that were included were published between 2006 and 2016. The participants were aged 13 years and above and comprised of sero-discordant couples, HIV patients, and male and female in the general population. These studies were conducted in multiple diverse regions including South Africa, Senegal, Uganda, Malawi, Kenya, Tanzania, Botswana and Zambia. Evidence showed that age and sexual partnerships were most commonly identified attributes to either HIV infection and/or transmission risks in men. While other biological and behavioral data were reported, the results were not specific to men. DISCUSSION: The impact of age and sexual partnerships are poorly understood and the data available limit inferences to South African men. Limited empiric evidence of HIV risk among men impacts on the design, development and tailoring of HIV prevention interventions to alter the trajectory.