Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular and Cell Biological Considerations in the Initiation and Development of Sporadic Non-Hereditary Solid Cancers

This paper reviews the state of cancer research in the post-mutation era. It presents cancer as a highly complex disease viewed differently by scientists from various research fields. Histopathologists considered cancer as a disease of cell differentiation, cancer cell biologists overestimated the causal role of accumulated DNA mutations. More recently molecular biologists have focused on driver genes and driver mutations, regulatory gene networks and deregulation of the genomic balance between unicellular and multicellular gene sets (UG/MG balance). From a developmental biological standpoint, there is a clear analogy between the reproductive life cycles of cancer and protists. The key player of both analogous life cycles is the polyploid cyst, the atavistic cyst-like structure aCLS (PGCC). In the analogy to protists, we assume that the first aCLS initiating cancer originates from a mitoticly blocked cell (cell of origin of cancer, protoprecursor) that escapes death entering an atavistic reproductive process of polyploidisation and depolyploidisation; it forms the atavistic cyst-like structure aCLS and numerous daughter cells (microcells). The microcell progeny develops a multi-lined cell lineage containing stem cells as well as somatic and reproductive cells and clones. Subsequent aCLSs are formed sequentially by committed daughter cells or occasionally by stressed somatic cells. Accordingly, cancer initiation occurs by genomic changes leading to the amitotic cell state and reactivation of an atavistic life cycle. In humans, atavistic life cycles and hyperpolyploidisation (n >16) are mostly repressed by stable gene regulatory networks – but not in cancer. The permanent UG/MG gene conflict and robust ancient surveillance mechanisms trigger a cascade of molecular lesions leading to genomic heterogeneity and aberrant cancer cell states.
Barthel Index (BI)

The Barthel Index (BI) serves as a measure of daily living activities in relation to personal care and mobility of the patient. The instrument was developed for chronic patients and long-term hospital patients with paralytic conditions, examining their performance before and after treatment. Barthel Index has been used for such tasks as predicting time needed for rehabilitation and amount of nursing aid required.
A communal approach to sexual need responsiveness in romantic relationships

ABSTRACT Sex is a crucial factor that impacts the quality and stability of relationships, yet many couples report recurrent sexual issues – such as discrepancies in their desired sexual frequency or levels of sexual desire – that detract from their relationship quality. This article describes how applying the theory of communal motivation from relationship science to the sexual domain of relationships can shed light onto understanding how couples can maintain desire over time, remain satisfied in the face of conflicting sexual interests, and decline one another’s sexual advances in ways that protect their relationship. We integrate a decade of research on communal motivation, sexual rejection, and responses to sexual rejection to provide a better, and more holistic, understanding of how partners can successfully balance their sexual needs to ultimately reap the powerful rewards of a fulfiling sexual connection.
Mitigation of climatic conditions and pest protection provided by insect-proof nets for cabbage cultivation in East Africa

Summary Although several studies have underlined the advantages of using insect-proof nets to improve yields while reducing the use of pesticides, one obstacle to the diffusion of this technique in tropical conditions is the associated increase in temperature in the tunnel. The aim of this work was to assess the interest of combining the physical protection provided by nets against insect pests with the beneficial impacts of using shade nets to grow cabbages. A two-season experiment was set up to compare temperature conditions, insect pest populations, yields, and the quality of cabbage crops grown in the open field and in low tunnels covered with nets providing different degrees of shading, 17.2% by white and 50.1% by silver nets. During the day, the temperature under the white and silver nets was 10.4 °C and 6.3 °C higher, respectively, than in the open field in the first season, and 6.5 °C and 5.9 °C higher in the second season. Both insect-proof nets significantly reduced insect pest populations and hence the need for insecticide treatments. The white nets increased marketable yield by 45.4% in the first season and by 16.4% in the second compared to yields in the open field, whereas silver nets reduced yield by 18.6% and 15.0%, respectively. The reduction in yield under silver nets was attributed to excessive shading that prevented the light requirements of cabbage crops from being fulfilled. Economic analysis raised some concerns about the profitability of the use of netting to grow cabbage due to investment costs and the lack of premium prices for vegetables produced with fewer pesticides in local markets.
Evaluating the relationship between serum uric acid levels with Killip classification suggestive of left heart failure in acute myocardial infarction

Background: Present evidence shows that increased uric acid level is a negative prognostic factor in patients with moderate to severe heart failure. A study has highlighted a correlation between serum uric acid levels and Killip class in patients of acute myocardial infarction (AMI). Aim of this study the relationship between serum uric acid level and Killip classification in patients with AMI.Methods: Sixty patients with AMI were studied prospectively in Department of Medicine/ Department of Cardiology, JA Group of Hospitals between 2016-2018. Patients were grouped based on the Killip class. Age, sex, history of smoking, alcohol consumption, hypertension and diabetes were recorded. Serum uric acid level were measured on Day 1, 3 and 5, which was compared with Killip class.Results: Majority of the patients were males (65%) and had age between (28.3%) 51-60 years. No significant association was obtained between any risk factors of AMI and Killip’s class (p>0.05). Serum uric acid levels were significantly higher in Killip grade III (7.80±3.57) as compared to Killip’s grade II (6.64±2.88) and I (6.30±2.33) (p=0.014). Majority of the patients with Killip’s grades I and II, had uric acid level ≤7.0 mg/dl (n=18 and n=9 respectively) (p=0.040). Serum uric acid was equally distributed among different types of killip’s grades between patients who expired and survived. (p>0.05). Conclusions: Serum uric acid levels has been found to be well correlated with Killip classification in patients with AMI. Combination of Killip class and serum uric acid level after AMI is a good predictor of mortality after AMI.
Experimental DNA - or RNA-Directed therapies for Trinucleotide Repeat Disease

Some repeats of three or more nucleotides in tandem, which are present in a gene or in its vicinity, tend to increase in number and for this reason are called dynamic mutations. These triplet repeats are unstable and can expand from one generation to the next. According to the expansion size, an unaffected individual can carry a pre-mutation that will expand through generations leading to the development of triplet repeat expansion diseases. The increase in the number of repeats over time leads to earlier development and increased severity of symptoms in affected individuals in successive generations. Although there is still no treatment for this type of disease, several strategies are under investigation. Here, we describe treatment approaches for triplet repeat expansion diseases that have been developed over recent years, using DNA or RNA molecules as targets. Some of these strategies have the potential for future use in gene therapy for trinucleotide repeat disorders.
Unequal recombination and other rearrangements in plant nuclear and chloroplast genomes

Plant genomes vary tremendously in terms of size and chromosome structure. One factor that plays a major role in genome evolution is homologous recombination. Both meiotic and mitotic recombination increase genetic diversity by rearranging combinations of alleles, creating new alleles and altering the copy numbers of genes by unequal recombination. Previous studies identified unequal recombination events between two disease resistance gene homologues from sorghum, Pc A and Pc C. Interestingly, most of the recombination events occurred in the least conserved part of the gene, which was the domain responsible for pathogen recognition. Changes here have the potential to allow evolution of new resistance specificities. We created transgenic maize lines containing tandem Pc A and Pc C genes, and then used a PCR assay to screen maize pollen for unequal recombination. We identified 23 unequal recombination events, yielding a rate of 1 per ~7700 pollen grains. DNA sequence analysis indicated that, unlike in sorghum, all unequal recombined Pc products had crossovers occurring in the conserved regions of the genes. Transposons are responsible for most plant genome variation. For instance, LTR retrotransposon amplification can rapidly increase a species’ genome size. This increase can be partially counteracted by unequal recombination between LTRs, deleting the internal sequence and leaving behind a solo LTR. We used the same techniques as for the Pc locus to identify a total of 23 unequal recombination events from 10 LTR retrotransposons. We found a positive correlation between recombination and LTR sequence identity and a negative correlation with DNA methylation. We also assembled and analyzed the chloroplast genomes from five species of parasitic plants. In most angiosperms, the chloroplast genome, or plastome, is highly conserved. We found several rearrangements and gene deletions in four of the five species. We also found large increases in plastome size. Plastomes contain two virtually identical inverted repeats separating a large and small single copy region. The plastome size increase was due to expansion of these repeats into the single copy regions. INDEX WORDS: unequal recombination, NBS-LRR genes, LTR retrotransposons, parasitic plants, plastomes UNEQUAL RECOMBINATION AND OTHER REARRANGEMENTS IN PLANT NUCLEAR AND CHLOROPLAST GENOMES by DANIEL CHRISTOPHER FRAILEY BA, University of Delaware, 2012 A Dissertation Submitted to the Graduate Faculty of The University of Georgia in Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY ATHENS, GEORGIA 2017
Consumers’ Behavior in Selective Waste Collection: A Case Study Regarding the Determinants from Romania

The increase in consumerism due to population growth, excessive advertising and the constant encouragement of buying behavior by advertising media and opinion formers comes with side effects for the environment and public health if it is not properly supported by a sustainable selective waste collection process. In this context, the paper aims at determining the impact of different elements on people’s intention to participate in selective waste collection and on their behavior related to the collection process. Based on the literature, a series of variables were considered and a questionnaire was created in order to extract people’s opinions related to the selective waste collection process. As discrepancies in findings might appear due to culture in various countries, the analysis has been conducted with reference to Romania’s case. The waste collection situation in Romania is similar in some ways to other countries in the world, with some differences related to a small recycling rate compared to other countries in the European Union. In this context, it is important to identify the determinants of the consumers’ behavior in selective waste collection and to act based on these findings. Creating better policies that can support the selective waste collection process will have results in increasing the waste collection rate, offering a clear and safer environment to all the citizens.
THE OVICIDAL EFFECT OF ALBENDAZOLE AGAINST WORM EGGS OFPARAMPHISTOMUM SPP. BY IN-VITRO

Albendazole is one of the modern anthelmintics that has effect vermicidal, larvicidal, and ovicidal. The sample used is the eggs of worms Paramphistomum spp. , obtained from the rumen of Bali cattle. This research is an experimental research laboratory and using complete random design. This study uses four different treatments with five repetitions so retrieved 20 types of worm eggs of Paramphistomum spp. research methods include the beginning of a collection of egg worm of Paramphistomum spp. , the dose given that is 0,06 mL Albendazole/40mL NaCl (P1), 0,12mL Albendazole /40mL NaCl (P2), 0,24 mL Albendazole/40 mL NaCl (P3) and control without treatment (P0). The eggs were observed on the 10th day and the 30th day, and then counting the number of eggs that do not hatch. The data obtained were tested statistically with ANOVA test and proceed with Duncan test to see the differences between the treatments. Albendazole has ovicidal effect against the worm eggs of Paramphistomum spp. by invitro. The doses of 0,24mL Albendazole/40mL NaCl (P3) give the highest percentage number worm eggs of Paramphistomum spp. are not hatching with 16.85%.
Role of analysis of variance (One way-anova) in music

Testing a New Technique but not sure how it stack up against all the alternative is very difficult as most of the options sound similar to each other so picking the best out of them is a challenge. Consider a scenario we have three music treatment to be apply on student to see their reaction as music enhance the concentration and consequently help student absorb new information I have to found kind of music would be good choice for this. I conduct a survey on randomly selected student from three different classes. Each Classroom was provided with a different environment for student to study in order to make a confident and reliable decision we need a evidence to support our approach. I used ANOVA technique for making best decision. ANOVA is defined as a statistical measure that analyze the variance of two, three or more comparable series for determining the significance of the difference in their mean values with the help of statistical technique known as F-test. The methodology was originally developed by Sir Ronald A. Fisher, the pioneered innovator of the use and application of statistical methods in experiment design who coined the name “Analysis of variance”-ANOVA.
Agritourism Activity—A “Smart Chance” for Mountain Rural Environment’s Sustainability

The debates regarding sustaining the rural world by improving the quality of life are numerous; one of the proposals being agritourism activity. This activity can be a “smart chance” for the sustainability of the mountain rural environment, because it has a multiplier effect on some important parts of economic and social life of the community. For instance, it can be an ally of agriculture, ensuring a diversification alternative for farms, an alternative for local guesthouses to capitalize their own local products, while ensuring the opportunity to obtain additional/complementary income, a possibility of adjusting the depopulation phenomenon and the abandonment of old houses and lands, at the same time offering a pleasant activity/alternative, especially for young people. In this context, the purpose followed in the paper is oriented through the transposition of agritourism activity into a “smart chance” for ensuring rural mountain sustainability. Being simultaneously an innovative and diversifying alternative, it is an actual one that starts from the study of two areas which are similar in terms of tourist potential. However, the approach is a different one, especially regarding the combination of agricultural resources with those specific to the rural way of life, and it also follows a different degree of development. Our scientific approach aims to present some aspects from the two areas, to achieve a general image of tourism potential, to identify how the agritourism activity is seen by those directly involved in its implementation, to point out some aspects due to which agritourism activity can be considered as a “smart chance” while bringing multiple benefits, and to ensure the sustainability of rural mountain areas by playing a vital role in the transition towards a more sustainable future.
Association between activities outside work and presenteeism among Korean wage workers: using nationwide survey

Introduction Presenteeism is a significant global health issue nowadays and can influence to producitivity loss. So, there were many studies to analyse relationship between workplace factor and presenteeism. But a few studies have considered non-occupational factor. The purpose of this study was to examine the association between presenteeism and activities outside work, such as, volunteering, self-development, leisure/sports, gardening & house repair activity, in Korean wage workers. Methods This study analysed the 4th Korean Working Condition Survey(KWCS) and overall 19,294 wage workers participated. To find the relationship between presenteeism and activities outside work, multivariate logistic regression analysis was used after adjusting for general and occupational characteristics. Results Among self-development, leisure/sports and gardening & house repair activities significantly increased the odds ratio of presenteeism (Odds ratio[OR] =1.33, 95% confidence interval[CI]: 1.23-1.43, OR = 1.40, 95% CI: 1.29-1.51 and OR = 1.09, 95% CI: 1.01-1.18, respectively). Conclusions Some of activities outside work were related to presenteeism in Korean wage workers. Although many of previous studies addressed positive effect of those activities for health, this study showed negative effect of activities oudside work for health. And we should consider Korean organizational culture for this reason and need more structural studies to find out specific factors.
Interaction of Fertilization and Weed Control Influences on Growth, Biomass, and Carbon in Eucalyptus Hybrid (E. pellita × E. brassiana)

Fertilization and weed control are regularly conducted as the main silvicultural prescriptions in the eucalyptus plantation forest. However, the interaction effects of both treatments on eucalyptus performance are still not deeply understood, even though these treatments require high investment. This circumstance may potentially inhibit the managers to formulate more efficient maintenance strategy for increasing stand productivity. This study examined the interaction effects of fertilization and weed control on growth, biomass, and carbon storage in eucalyptus hybrid (E. pellita x E. brassiana). Results demonstrated that without both treatments, the average stand volume only reached 37.9 m3 ha -1 with the mean biomass and carbon storage approached 25.4 and 12.7 Mg ha -1, respectively. In contrast, the use of both treatments simultaneously improved the mean volume around 60.4 m3 ha -1 with the average biomass and carbon storage closed to 37.6 and 18.8 Mg ha -1. Furthermore, the development of eucalyptus hybrid using fertilization without weed control only gained the mean wood production approximately 58.7 m3 ha -1 while the practice of weed control without fertilization only resulted the average volume nearly 43.7 m3 ha -1. These facts indicated fertilization exhibited higher influence than weed control on the performance of eucalyptus hybrid.
Physico Chemical Characterization of Fiber from Melia Azedarach Barks as an Effective Reinforcement in Polymer Matrices

ABSTRACT The present study aimed to investigate the physico-chemical properties of new cellulosic fiber obtained from the bark of Melia Azedarach tree. The investigation outcomes revealed that, the cellulose content, crystallinity index and density of Melia Azedarach Fiber (MAF) were determined as 66.5 wt. %, 45.45% and 950 Kg/m3, respectively. The MAF had thermal stability up to 220θC which is evidenced from the thermo gravimetric analysis. The Fourier Transform Infra Red test clearly specified the existence of cellulosic and non-cellulosic substance in MAF. The morphological analysis showed that MAF contains smooth surfaces and its diameter is measured as 48.2 ± 2 µm. The results of this investigation on MAF were evident that it can be used as future reinforcement material to develop the green composite for potential applications.
Polarization Detection of Electromagnetic Waves Using Cascaded Wilkinson Power Dividers

This letter presents a new technique for determining the polarization of the electromagnetic waves by using a passive circuit. The necessary mathematical operations required to retrieve the polarization are achieved using a passive circuit built with the cascaded Wilkinson power dividers. This technique is robust and simple, and enables the detection of all necessary characteristics for determining the incident-wave polarization. It requires two orthogonal linearly polarized antennas for amplitude measurements only. Measurement results with two circularly polarized patch antennas are shown in order to validate the proposed technique. A comparison with a classic method is also provided, which confirms the accuracy and simplicity of the technique.
Adaptive Neural Network Conformable Fractional-Order Nonsingular Terminal Sliding Mode Control for a Class of Second-Order Nonlinear Systems

The paper introduces a novel adaptive neural network fractional-order nonsingular terminal sliding mode controller using conformable fractional-order (CFO) derivative for a class of uncertain nonlinear systems. For this purpose, a new conformable fractional-order nonlinear sliding surface is proposed and the corresponding control law is designed using Lyapunov stability theorem in order to satisfy the sliding condition in finite time. To deal with uncertainties, the lumped uncertainty is approximated by neural networks and adaptation laws are designed using Lyapunov stability concept. As adaptive neural network uses small switching control gain in the presence of large time varying uncertainties the chattering phenomenon is omitted. The proposed adaptive neural network conformable fractional-order nonsingular terminal sliding mode controller (ANN-CFONTSMC) exhibits better control performance, guaranties finite-time convergence and robust stability of the closed-loop control system. Finally, effectiveness of the proposed controller is illustrated through numerical simulations.