Miracle-dz/UniFAR-FTUs huggingface dataset:
Alterações funcionais da albumina na cirrose hepática

Human serum albumin (HSA) is the most abundant circulating plasma protein. Besides accounting for about 70% of the plasma colloid osmotic pressure, it is also involved in the regulation of many other physiological processes, including the balance of the redox state, inflammatory or immunological responses, and the pharmacokinetic and pharmacodynamics of many drugs. Growing evidence suggests that albumin undergoes structural and functional damage in diseases characterized by an enhanced systemic inflammatory response and oxidative stress, as it occurs in liver cirrhosis. The relative abundance of the native non-modified form of albumin is significantly reduced in hospitalized patients with cirrhosis. Furthermore, albumin modifications worsen in parallel with the increasing severity of the disease. In fact, modified albumin isoforms have shown to be independently associated with specific clinical complications and mortality, whereas the native HSA isoform independently predicts survival in patients with liver cirrhosis. These findings support the concept of effective albumin concentration , which implies that the global albumin function depends not only on its serum concentration, but also on the preservation of its structural integrity. In patients with cirrhosis, albumin infusion reduces mortality from spontaneous bacterial peritonitis and reduces complications from large volume paracentesis. In combination with vasoconstrictors, albumin is useful in the management of patients with hepatorrenal syndrome. The role of albumin replacement is also being investigated in many other indications, which rely mainly on its non-oncotic properties, showing that albumin is more than just a plasma volume expander. This review discusses the pleiotropic properties of albumin and the biologic and clinical implications of structural and functional changes of albumin that are associated with cirrhosis. Based on these insights, this review also explores the current therapeutic uses of albumin in liver cirrhosis.
Assessment of cashew species for molecular diversity.

Genetic diversity in ten accessions of cashew consisting of three wild species, four genotypes of cultivated species and three interspecific hybrids was studied using RAPD, microsatellite (SSR) and Isozyme markers. Polymorphic bands generated with 11 RAPD primers, six primer pairs of SSR and Isozymes of six enzymes were used for analysis. A total of 151 bands were obtained with 123 polymorphic bands (81.5%) by combining the markers data. High percentage of polymorphism in markers and an average genetic similarity of 54% suggested high genetic variation and moderate diversity existing among the accessions. The Unweighted Pair Group Method with Arithmetic averaging cluster analysis made on genetic similarity grouped the accessions broadly into three major clusters. In these, Anacardium pumilum with its inter-specific hybrids and Anacardium orthonianum with its inter-specific hybrid clustered separately and only Anacardium occidentale clustered with Anacardium microcarpum indicating close affinity between these two species. Even morphologically these two species showed resemblance.
How the dominant reading direction changes parafoveal processing: A combined EEG/eye-tracking study

Reading directions vary across writing systems. Through long-term experience readers adjust their visual systems to the dominant reading direction in their writing systems. However, little is known about the neural correlates underlying these adjustments because different writing systems do not just differ in reading direction, but also regarding visual and linguistic properties. Here, we took advantage that Chinese is read to different degrees in left-right or top-down directions in different regions. We investigated visual word processing in participants from Taiwan (both top-down and left-right directions) and from mainland China (only left-right direction). Combined EEG/eye tracking was used together with a saccade-contingent parafoveal preview manipulation to investigate neural correlates, while participants read 5-word lists. Fixation-related potentials (FRPs) showed a reduced late N1 effect (preview positivity), but this effect was modulated by the prior experience with a specific reading direction. Results replicate previous findings that valid previews facilitate visual word processing, as indicated by reduced FRP activation. Critically, the results indicate that this facilitation effect depends on experience with a given reading direction, suggesting a specific mechanism how cultural experience shapes the way people process visual information.
Aligning HST Images to Gaia: A Faster Mosaicking Workflow

We present a fully programmatic workﬂow for aligning HST images using the high-quality astrometry provided by Gaia Data Release 1. Code provided in a Jupyter Notebook ( https: // github. com/ spacetelescope/ gaia_ alignment ) works through this procedure, including parsing the data to determine the query area parameters, querying Gaia for the coordinate catalog, and using the catalog with TweakReg as a reference catalog. This workﬂow greatly simpliﬁes the normally time-consuming process of aligning HST images, especially those taken as part of mosaics.
Resistance to Reactive Oxygen Species and Antioxidant Activities of Some Strains of Lactic Acid Bacteria from the Mustard Leaf Kimchi

In present study, five strains of Lactobacillus acidophilus GK20, Lactobacillus brevis GK55, Lactobacillus paracasei GK74, Lactobacillus plantarum GK81, and Leuconostoc mesenteroides GK104 isolated from the mustard leaf kimchi were investigated for resistance to reactive oxygen species (ROS) and antioxidant activity. L. acidophilus GK20, L. brevis GK55, L. paracasei GK74, and L. plantarum GK81 were resistant to hydrogen peroxide (0.5 mM), showing a survival rate of 50% or more. In particular, L. acidophilus GK20 and L. paracasei GK74 were the most superoxide anions-resistant and L. paracasei GK74 and L. plantarum GK81 were most likely survive hydroxyl radicals. Meanwhile, the intracellular cell-free extract (ICFE) from L. plantarum GK81 exhibited significantly higher DPPH radical scavenging values () than the intact cells (IC). The ICFE of L. plantarum GK81 showed the highest superoxide radical scavenging ability and chelating activity for ions among the 5 lactic acid bacteria (LAB) tested, and IC and ICFE from L. plantarum GK81 demonstrated excellent reducing activity, which was higher than those of BHA and vitamin C as a positive control.
Modulation of Signal Transduction Pathways in Senescence-Accelerated Mice P8 Strain: A Useful Tool for Alzheimer’s Disease Research

Jose Luis Albasanz1, Carlos Alberto Castillo1,2, Marta Barrachina3,4, Isidre Ferrer3,4,5 and Mairena Martin1 1Departamento de Quimica Inorganica, Organica y Bioquimica, Facultad de Quimicas, Centro Regional de Investigaciones Biomedicas, Universidad de Castilla-La Mancha, Ciudad Real 2Departamento de Enfermeria, Facultad de Terapia Ocupacional, Logopedia y Enfermeria, Universidad de Castilla-La Mancha, Talavera de la Reina 3Institute of Neuropathology, Bellvitge University Hospital-ICS, Bellvitge Biomedical Research Institute IDIBELL, L’Hospitalet de Llobregat 4Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, CIBERNED, Barcelona 5University of Barcelona-IDIBELL, Department of Pathology and Experimental Therapeutics, L’Hospitalet de Llobregat Spain
Influence of locality on content of phenolic compounds in white wines

Lampiř L. , Pavlousek P. (2013): Influence of locality on content of phenolic compounds in white wines. Czech J. Food Sci., 31: 619–626. Phenolic compounds in grapes and wines are significantly influenced by the environment. Phenolic compounds in grapes are therefore a good reflection of terroir. The authentic wines were made from seven white grape varieties and two localities in the Czech Republic. Sadek is a location on the edge of production wine-growing in the Czech Republic and Perna is a typical wine-growing location in the Czech Republic. The profile of phenolic compounds was analysed by HPLC. Based on the statistical evaluation of these results, the following phenolic compounds were found to very well reflect the terroir conditions: protocatechuic acid, p-hydroxybenzoic acid, caftaric acid, cis-piceid, (+)-catechin and (–)-epicatechin. Since these compounds were not influenced significantly by vintage, they can be good markers of terroir.
Route of entry-dependent blocks to retroviral replication

Restriction factors are endogenous cellular proteins that block retroviral replication at specific points in the life cycle. Those identified so far include Fv1 Trim5αand TrimCyp. Their characterisation has extended knowledge of retroviral and cellular functions, and has added a new branch to innate immunity. Retroviral susceptibility to Fv1 and Trim5α is determined by its capsid, and is manifested in a pre- (Trim5α, TrimCyp) or post- (Fv1) reverse transcription block to replication. Other blocks to replication have been postulated. For example, a novel anti-viral factor, Lv2, is thought to block replication of several primary isolates of HIV-2 in some cell lines. Knowledge of the early steps of virus replication, between entry and nuclear import, is critical to understanding restriction. The intention of the studies described in this thesis was to determine whether alternative routes of virus trafficking might affect susceptibility to Fv1 and Trim5α, as well as to the putative Lv2. A system of two receptors was used, Tva800 and Tva950; both permit entry via ASLV envelope protein, but take the virus into the cell by two different endocytic mechanisms. The pathways traversed after binding to Tva800 and Tva950 were investigated and shown not to reroute virions around restriction mediated by Fv1 and Trim5α. When virus titration curves were analysed, a distinctive pattern emerged suggesting that entry via Tva800, but not Tva950, requires engagement of more than one receptor-envelope pair. The block to replication caused by the putative factor Lv2 was also analysed. It was concluded that a combination of low surface CD4 expression and poor receptor engagement are the cause of low viral titres in some cell lines, rather than a cellular anti-viral factor per se.
Social support experiences of breast cancer patients

Breast cancer is the most common cancer in women worldwide. After receiving diagnosis and during treatments breast cancer patients often find themselves vulnerable and in need of social support. Receiving social support may relieve patients’ stress, help them cope with the situation and improve their general well-being. The aim of the study was to describe breast cancer patients’ experiences of social support during their illness. The purpose was to present most recent information for nurses that can help them to acknowledge patients’ individual support needs in order to better meet them. Furthermore, this could improve the outcomes of social support provided by nurses. The study was implemented as a literature review. The data were collected using two databases: CINAHL and MEDLINE, resulting in the selection of seven articles that were analyzed using inductive content analysis. The following four main categories of social support experiences emerged from the analysis: emotional support experiences, informational support experiences, instrumental support experiences and spiritual support experiences. As a conclusion, it was found that breast cancer patients’ experiences of social support are highly personal and reflect their individual needs. Women’s experiences may further be affected by their native or adapted cultures and also by their religions. Therefore, nurses should provide breast cancer patients with more personalized care that would pay attention to their personality, age, religion and cultural background. Nurses could also routinely contact women who are waiting for surgery and make a follow-up call after treatments, which would improve both emotional and informational support for breast cancer patients.
Aspectos funcionais e evolutivos da família WAK em Oryza Sativa

10 CAPÍTULO I – INTRODUÇÃO GERAL 12 PROTEÍNAS QUINASE EM EUCARIOTOS – EPK 13 RECEPTORES QUINASE EM PLANTAS – RLK 16 A SUBFAMÍLIA GÊNICA WAK 19 OBJETIVOS ESPECÍFICOS 24 CAPÍTULO II – EVOLUTION AND EXPRESSION OF WALL-ASSOCIATED KINASE GENE FAMILY IN RICE GENOMES 25 INTRODUCTION 28 CAPÍTULO III – CONSIDERAÇÕES FINAIS 82 DISCUSSÃO E CONCLUSÃO 83 PERSPECTIVAS 87 REFERÊNCIAS 89
GEOGRAPHIC INFORMATION SYSTEMS FOR ASSESSMENT OF CLIMATE CHANGE EFFECTS ON TEFF IN ETHIOPIA

The value of Geographic Information Systems (GIS) for assessing climate change impacts on crop productivity cannot be over-emphasised. This study evaluated a GIS based methodology for teff (Eragrostis tef ) production in Ethiopia. We examined the spatial implications of climate change on areas suitable for teff, and estimated the effects of altered environments on teff’s productivity. There was a non-linear relationship between suitability indices, the output of spatial analysis and teff yield data collected from diverse ecological zones. This served as the basis for country-wide crop yield analysis for both current and future climate scenarios. To complement this effort, a socio-economic survey was carried with a thrust of understanding the agricultural activities in the study area. With the current climatic conditions, 87.7% of Ethiopia is suitable for teff. On the other hand, approximately 67.7% of Ethiopia is expected to be suitable for teff production by 2050. Suitability index (SI) and the actual crop yield data showed a strong positive correlation (r = 74%). There is a predicted severe drop in teff yield (-0.46 t ha -1 ) by the year 2050. Based on the current area under teff in Ethiopia, this equals an overall reduction in national production of about 1,190,784.12 t, equivalent to a loss of US$ 651 million to farmers. The results indicate that crop yield varied significantly as a function of climatic variation and that the model is applicable in assessing the impact of climate change on crop productivity at various levels taking into consideration spatial variability of climate.
Meningkatkan Keterampilan Smash Tenis Meja dengan Pendekatan Taktis

Meningkatkan Keterampilan Smash Tenis Meja dengan Pendekatan Taktis. Penelitian ini berupa penelitian tindakan untuk meningkatkan keterampilan smash tenis meja siswa ekstrakulikuler tenis meja SD Negeri Pasirmulya II Kabupaten Karawang, dengan jumlah 20 siswa. Penelitian tindakan ini menggunakan model Kemmis dan Taggart yang terdiri dari dua siklus. Dalam latihan smash tenis meja ini menggunakan pendekatan taktis untuk mencapai tujuan yang diinginkan. Data dikumpulkan melalui pengamatan observer berupa tes keterampilan smash ; catatan lapangan; dan dokumen selama penelitian berlangsung. Hasil penelitian menunjukan bahwa setelah dilakukan tindakan menggunakan pendekatan taktis pada siklus I diperoleh hasil 70% dengan jumlah 14 siswa yang mencapai criteria ketuntasan minimal (KKM) dan 30% dengan jumlah 6 siswa yang belum mencapai criteria ketuntasan minimal dengan nilai rata-rata mencapai 74 untuk forehand smash ; dan 65% dengan jumlah 13 siswa yang mencapai kriteria ketuntasan minimal dan 35% dengan jumlah 7 siswa yang belum mencapai ketuntasan minimal dengan nilai rata-rata 73 untuk backhand smash . Pada siklus II diperoleh hasil 85% dengan jumlah 17 siswa yang mencapai criteria ketuntasan minimal dan 15% dengan jumlah 3 siswa yang belum mencapai criteria ketuntasan minimal dengan nilai rata-rata mencapai 80 untuk forehand smash ; dan 80% dengan jumlah 16 siswa yang mencapai criteria ketuntasan minimum dan 20% dengan jumlah 4 siswa yang belum mencapai ketuntasan minimal dengan nilai rata-rata 76 untuk backhand smash . Berdasarkan hasil penelitian, dapat disimpulkan bahwa penerapan pendekatan taktis dapat meningkatan keterampilan smash tenis meja siswa ekstrakulikuler tenis meja SD Pasirmulya II Kabupaten Karawang.
PARASITOSIS PULMONAR POR Aelurostrongylus abstrusus EN UN FELINO

A un felino hospitalizado en un clinica veterinaria de la ciudad de Bogota con sintomatologia de disnea, estertores, hemoptisis y epistaxis, se le realizo un muestreo coprologico con el fin de determinar la eliminacion de ooquistes de Toxoplasma gondii mediante la prueba de Ritchie y se determino la presencia de formas larvarias del parasito Aelurostrongylus abstrusus . Teniendo en cuenta dicho hallazgo se recomendo tratar al paciente con Mebendazol a una dosis de 50 mg/Kg/12h durante 5 dias. El paciente fue dado de alta respondiendo favorablemente al tratamiento
When and where to have sex? : different modes of reproduction and life history traits in the facultative parthenogenetic ant Platythyrea punctata

Hymenopterans generally exhibit a haplo-diploid sex determination mechanism, in which females are produced by sexual reproduction and are diploid and males are produced parthenogenetically and are haploid. In a small number of ant species, workers are able to produce diploid female offspring parthenogenetically from unfertilized eggs, which is termed thelytoky. One of these species, the ponerine ant Platythyrea punctata, is of peculiar interest, because it has been found to have both thelytokous and sexual colonies, which makes it an interesting model system to investigate population structures, colony relatedness patterns and behavioral colony performance that may give new insights on the evolution of thelytoky in social Hymenoptera. The aim of this thesis was to investigate consequences of thelytoky on the genetic population and colony structures and behavioral performance within colonies. By combining genetic and ethological studies, I analyzed the geographic range of thelytokous and sexual populations, the mechanisms underlying thelytoky and male production, as well as other aspects of behavioral performance in social insect colonies with clonal structures.
STRUKTUR, KOMPOSISI DAN STATUS TUMBUHAN OBAT DL KAWASAN HUTAN TAMAN NASIONAL ALAS PURWO

Alas Purwo National Park is one of representative tropical low rain forests at eastern Java. There are many natural attractive sites and historical legend, which lead to, famous for ecotourisme activities. There are also rich of flora and fauna that some of them endemic and endangered species. Medicinal plant is one important material on the forest, which still unexplored more. Ten sampling transects were established in some sector of Alas Purwo for inventory of wild medicinal plants. The result shows that at least 5 species have been categorized as an endangered plant. Meanwhile, the structure and composition of endangered medicinal plants is not better than common medicinal plants.
Impactos do crédito rural no mercado de trabalho da agropecuária dos estados brasileiros

This paper analyses the repercussions of rural credit on agricultural labour market of Brazilian states, particularly on wages and employment level of this sector. For this a panel data was built with information on real wages, formal jobs criated, rural credit and agricultural GDP between 2002-2015 for all 26 brazilian states. Evidence was withdrawn from cumulative impulse response functions obtained from Panel Vector Autoregressive (PVAR) models. The results indicated that real wages and agricultural GDP respond positively to shocks in rural credit and that, under similar conditions, the employment level presents a slightly reduction in the aggregate model. However, considering models for regional subsamples, there is evidence of positive impacts of agricultural credit on employment in the states of the North and Northeast regions, with labor-intensive farming, whereas negative repercussions on employment were found in Midwest, South and Southeast states, wich are more capital intensive.
Insights into the regulation of the fanconi anemia FANCD2 protein

Fanconi anemia (FA) is a rare autosomal and X-linked recessive disorder, characterized by congenital abnormalities, pediatric bone marrow failure and cancer susceptibility. FA is caused by biallelic mutations in any one of 16 genes. The FA proteins function cooperatively in the FA-BRCA pathway to repair DNA interstrand crosslinks (ICLs). The monoubiquitination of FANCD2 and FANCI is a central step in the activation of the FA-BRCA pathway and is required for targeting these proteins to chromatin. Despite their critical role in ICL repair, very little is known about the structure, function, and regulation of the FANCD2 and FANCI proteins, or how they are targeted to the nucleus and chromatin. The goal of this dissertation is to study the mechanisms and regulation of FANCD2. Through this research, we have uncovered a nuclear localization signal (NLS) in FANCD2. Mutation of this NLS region impairs FANCD2 and FANCI monoubiquitination and inhibits the recruitment of FANCD2 and FANCI to chromatin. In addition, we have identified a putative CDK phosphorylation site cluster in FANCD2. Taken together, we believe these findings have enhanced our understanding of this important DNA repair protein and will allow for further investigation of this rare cancer susceptibility syndrome.