Miracle-dz/UniFAR-FTUs huggingface dataset:
Can the consumption of Seeds, Leaves and Fruit Peels avoid the risk factors for Cardiovascular Disorders?

Changes in the feeding pattern of the population have recently led to a greater occurrence of cardiovascular risk factors that contribute to a high rate of morbidity and mortality worldwide. The presence of beneficial bioactive compounds in fruits and processed sub-products have proven to have a negative association with risk factors, such as blood pressure reduction, plasmatic lipoproteins control and increased resistance of LDL-c to oxidation, in addition to glycemic control and antioxidant effects. The aim of this review is to show that several studies have demonstrated many different chemical compounds in seeds, leaves and fruit peels, including their metabolic and physiologic effects on the risk factors of cardiovascular diseases. We reviewed the relevant literature by searching English-language publications in Pubmed, Google Scholar, Scielo and Lilacs, and references from relevant articles published since 2010, especially in the last five years. Eighty-seven relevant articles were included.
Theories of Delinquency: An Examination of Explanations of Delinquent Behavior

Explanations of delinquency -- The classical school : issues of choice and reasoning -- Biological and biosocial explanations -- Psychological theories -- Social disorganization and anomie -- Lower-class-based theories of delinquency -- Interpersonal and situational explanations -- Control theories -- Labeling theory -- The radical theory of delinquency -- Female delinquency -- Delinquency theory : an integrative approach.
Oral hygiene practices and factors influencing the choice of oral hygiene materials among undergraduate students at the University of Port Harcourt, Rivers State, Nigeria

Objectives: The objectives of this study were to determine oral hygiene practices among university students; establish any association between oral hygiene practices and sociodemographic variables and find out the factors that may influence the choice of oral hygiene products in this group. Materials and Methods: Self-administered questionnaire containing information on age, gender, material used for tooth cleaning, and frequency of tooth cleaning was completed by the students in their hostels. Data were analyzed using SPSS version 20.0. Test of significance was carried out using Chi-square and logistic regression analysis. Association was considered statistically significant when P ≤ 0.05. Results: In the present study, all the participants irrespective of the age, gender, and field of study used toothbrush and toothpaste as the oral hygiene tool. The use of dental floss, mouth rinse, and interproximal brush was not recorded in this study. About 24% of the participants reported using fluoride-containing toothpastes. Cleaning the teeth twice daily was significantly related to age (P = 0.046), gender (P = 0.01), and field of study (P = 0.032). Logistic regression analysis shows that the relationship between the sociodemographic characteristics of the participants and their frequency of tooth cleaning was statistically significant. The cost was the major factor influencing the selection of oral hygiene tools. Conclusion: The oral hygiene practices of the participants were suboptimal. Less than two-third of the sample cleaned their teeth twice daily. Age, gender, and field of study were significant determinants of oral hygiene practice. The major factor which influenced the selection of toothpaste and toothbrush was the cost.
Evidence on Antimicrobial Efficacy of Commercial Toothpaste

This study aims to determine the antimicrobial activity of different brand of commercially available toothpaste in Malaysian outlet, namely Colgate-Total, Mu’min, Tesco and Safi against selected oral microbiome. All the different toothpastes brand were tested for their antimicrobial activity against five oral pathogens namely Staphylococcus aureus, Proteus mirabilis, Salmonella typhi, Klebsiella pneumonia and Escherichia coli by using agar well diffusion method. Colgate-Total brand has the highest mean zone of inhibition (Z.O.I) on the test organisms (30.7 mm) followed by Safi brand (29.2 mm) and Tesco brand (12.5 mm) while Mu’min brand showed the least activity on the test micro-organisms (2.4 mm). The present work found Colgate-total brand toothpaste more effective in controlling pathogenic oral microflora as compared to other brand of toothpaste. Original Research Article Fazlina and Nur; JAMB, 8(1): 1-8, 2018; Article no.JAMB. 38682 2
Psychosocial Antecedents of Psychological Wellbeing of Local Government Employees

Psychological wellbeing among local government employees has continued to be a source of concern to psychologists and concerned stakeholders in Nigeria. It is in this light that this study examined the predictive role of family dynamics, social support and resilience on psychological wellbeing among local government employees in Ibadan. A total number of two hundred and ninety-six (N=296, Male = 86, Female = 197, M=38.87, SD=9.47) constitute the respondents which were selected using purposive sampling technique. A structured questionnaire consisted of demographics and scales were used to collect data in this study. Result showed that there was significant positive relationship between resilience, social support family dynamic and psychological wellbeing. There was joint prediction of resilience, social support and family support existed on psychological wellbeing. The study therefore recommends that trained Psychologists should develop psychological intervention programs tailored toward resilience, social support and family dynamic which invariably would improve psychological wellbeing.
Effect of Tualang Honey in Acute Kidney Injury Animal Model

BACKGROUND: Many researches have proven that there exists a complex association between progressive renal damage and hypercholesterolemia. However, there was little information about the early effect of hypercholesterolemia on the kidney. Additionally, although there is a growing insight into the causes and mechanisms of these diseases, preventive and therapeutic measures are still few. Hence, the aim of this study is to determine the acute and sub-acute effects of high cholesterol diet on the kidney, and to examine the protective role of tualang honey against these disease. METHODOLOGY: Fifteen female Sprague-Dawley rats were randomly divided into three groups: control group, fed with commercial rat pellet; high cholesterol diet group (HCD), fed with 12% cholesterol diet with 0.3% cholic acid, and HCD with tualang honey supplements at 1.4 g/kg/day orally group (HCD+TH). Biochemical analyses for lipid profile and renal function test were performed at completed 48 hours (day 3), day 7, and day 42 of the experiment. The rats were sacrificed at completed day 42 and the kidneys were harvested and subjected to histopathological examination. The data were analysed using ANOVA and LSD Post-Hoc test. RESULTS: Consumption of 12% cholesterol diet for six weeks resulted in an increment of the mean serum creatinine level of HCD and HCD+TH groups to 1.5 times the control level at the completed day 7. Also overall both the mean serum creatinine and blood urea levels were higher in HCD group than the control group. The mean TC showed an increasing trend throughout the experiment with the level being significantly higher than the control group at the completed day 42. A significantly higher mean serum LDL-c in the HCD group as compared to the control at the completed day 42 was also documented. The mean serum TG levels were higher than that of the control group at the completed 48 hours and day 7. The mean serum HDL-c showed a significant reduction in HCD group than the control group at the completed day 42. With tualang honey supplementation, the mean serum creatinine level showed significant reduction at 48 hours in the HCD+TH group as compared to the HCD group. There was also a reduction in the mean serum creatinine level at the completed day 42. As for the lipid profile, honey supplementation significantly reduced the mean TG and vLDL-c at the completed day 7 as compared to HCD group. Histopathologically the kidneys exhibited segmental mesangial hypercellularity and mesangial matrix expansion of almost all the glomeruli in both HCD and HCD+TH groups. CONCLUSION: The 12% cholesterol diet utilized in this study caused acute and sub-acute kidney injuries in the animal model while tualang honey at 1.4 g/kg/day orally exhibited lipid lowering activities and some degree of renoprotective effect against high cholesterol diet induced kidney injury.
Proposal of Product-Replenishment Policy Determination on Multi-Source Problems to Minimize Over Stock in DC PT. XYZ Area Bandung Using Mixed-Integer Programming Method

XYZ is one of the companies engaging in fast moving consumer goods (FMCG) sector and produce soft drinks as its main product. In supporting the product distribution to its customers, PT XYZ has several administrative offices and distribution centers (DC) which spread across each region. The DC has main function as the warehouse which has storage activity before the products are distributed. One of the DC is located in Bandung, West Java. DC Bandung itself received product shipments from three factories, such as Cibitung, Cakung and Tambun. Related to the product shipment, DC Bandung has not determined the replenishment policy, and this condition results over stock at some periods, due to the unscheduled delivery time and undetermined product quantity. This condition gives a big impact to the total inventory cost that has to be borne by DC Bandung. This research was conducted to give the proposal of product replenishment policy using mathematical model with mixed-integer programming method as one of the linear programming types, which aimed to minimize over stock and total holding cost in DC Bandung with several constraints. Mathematical modeling is involved in this research as an approximation to the real replenishment system in the DC. The results of application of the proposed method are in the form of analytical solution, such as order quantity, and reorder point of each product that will give an impact to the total unit inventory and the total holding cost in the DC. The results calculation of replenishment policy provide savings on total inventory costs as much as IDR 23,800,981.20 Keywords—Mixed-Integer Programming, Order Quantity, Over Stock, Replenishment Policy.
M24 Do antifibrotics impact on lung transplantation outcomes in idiopathic pulmonary fibrosis?

Introduction Antifibrotics slow progression of forced vital capacity (FVC) in patients with moderate Idiopathic Pulmonary Fibrosis (IPF) (FVC 50%–80%). 1,2 Lung transplantation (LTx) is also a management option in a small cohort of patients who meet stringent eligibility criteria. With increased use of antifibrotics, questions remain about their safety in IPF patients undergoing LTx. Methods All patients with multidisciplinary team (MDT) diagnosis of IPF that underwent lung transplantation from April 2013 to April 2017 were recruited from a single tertiary centre for ILD and lung transplantation. Retrospective data was obtained from medical notes. Statistical analysis was performed using chi squared test for categorical values and unpaired t-test. Results 22 IPF patients (male 81.8%, female 18.2%) with mean age of 61.9 (+/-4.9) underwent single (n=16) and double (n=6) LTx. 15 (68%) received antifibrotics during the pre-transplantation period (pirfenidone n=14, nintedanib n=1) and 7 did not. Two patients actually had rheumatoid arthritis associated lung disease and were on immunosuppressant. Average waiting time for LTx was 7.0 months (+/-4.7 months). All patients on antifibrotics were on full dose, although 3 of them had a transient dose interruption at the start of their treatment with antifibrotics. Eight (36%) patients had complications post LTx, of which 4 died (antifibrotics, n=2) after the LTx due to multiple complications. 14 patients (64%) did not have complications at 3 months (antifibrotics n=10). There was no statistical significance between post-operative complication and age (p=0.6), gender (p=0.53) or antifibrotics use (p=0.67). Conclusion Our data showed similar findings to a recent Belgian3 study that antifibrotics use prior to LTx does not impact on LTx outcomes or complications. References . Richeldi L, du Bois RM, Raghu G, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med2014;370(22):2071–82. King Jr TE, Bradford WZ, Castro-Bernardini S, et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med2014;370(22):2083–92. Delanote I, Wuyts WA, Yserbyt J, et al. Safety and efficacy of bridging to lung transplantation with antifibrotic drugs in idiopathic pulmonary fibrosis: a case series. BMC Pulmonary Medicine2016;16:156.
Synthesis and Mechanical Characterization of Chitosan Threads for Biomedical Applications

Chitosan is a biopolymer widely used for many applications, especially in the biomedical field, due to its interesting properties like excellent sorption capability, biodegradability and biocompatibility. The presence of reactive groups in the structure of this biopolymer makes possible the attachment of different molecules. In this study a chitosan thread is synthesized, using a microfluidic technique with two merging channels of acidic chitosan and hydroxide, in order to use it as a controlled release device of drugs. Varying the flows of the fluids in the channels is possible to control the diameter of the thread, obtaining samples of medium and high molecular weight for each flow rate used in the synthesis. The obtained thread of chitosan was mechanically characterized performing tensile tests until failure and stress relaxation tests. An optical system of polarizers was set to visualize the alignment of the polymeric chains while the material is elongated during the tensile test. Young modulus is obtained for each type of sample to quantify the stiffness of the material, and relaxation times were calculated to observe the viscoelastic behavior. Alignment of the material was confirmed, since birefringence was shown.
Molekulare Entzündungsdiagnostik im 21. Jahrhundert – der Weg zu mehr Spezifität und individualisierter Medizin?

Zusammenfassung Die Diagnostik entzündlicher Erkrankungen stellt nach wie vor eine große klinische Herausforderung dar. Die molekulare Bildgebung erlaubt die Darstellung eines entzündlichen Geschehens in vivo, wobei pathophysiologische Veränderungen in einer frühen Phase des Entzündungsprozesses noch vor dem Auftreten anatomischer Veränderungen detektierbar sind. Es stehen verschiedene nuklearmedizinische Tracer zur Entzündungsdiagnostik mittels Gammakamera und PET/CT mit unterschiedlicher Spezifität zur Darstellung einer Entzündung zur Verfügung. Der vorliegende Artikel befasst sich schwerpunktmäßig mit den Entwicklungen der nuklearmedizinischen Entzündungsdiagnostik in den letzten 16 Jahren. Auf dem Weg zu mehr Spezifität und Individualität in der Bildgebung akuter und chronischer Entzündungen werden erste Ergebnisse über die klinische Anwendung neue Tracer, mit ihren jeweiligen Vorzügen und Limitationen, vorgestellt.
Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 status of breast cancers in women visiting the Jos University Teaching Hospital

Introduction: Breast cancer remains the most common malignancy in women and the leading cause of morbidity and mortality in this gender. The disease in the indigenous African woman is associated with an inherent aggressive biology and worst clinical outcome. As the malignancy is a heterogeneous entity, each case must be individually categorized for efficient therapy. Current clinical practice employs the use of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), as biomarkers to appropriately select patients that would benefit from targeted therapy against these major molecular pathways of the disease. This study aims at establishing the ER, PR, and HER2 status of breast cancer in women visiting the Jos University Teaching Hospital. Materials and Methods: All histologically confirmed cases of breast cancer at the Jos University Teaching Hospital, between January 1, 2010, and December 31, 2012, with sufficient clinical records, were subjected to immunohistochemistry for the ER, PR, and HER2 status. Results: A total of 96 cases of female breast cancers were histologically diagnosed during the period of the study. Sixty-three (65.6%) cases met the inclusion criteria. The predominant histological type was invasive carcinoma (no special type) accounting for 54 (85.7%) cases. Scarf Bloom Richardson Grade 1, 2, and 3 for the cancer cases were: 18 (28.6%), 29 (46.0%), and 16 (25.4%), respectively. The rate of ER, PR, and HER2 positivity were 36.5%, 28.6%, and 33.3%, respectively. There were 26 (41.3%) triple-negative cases. Conclusion: The study shows a relatively low rate of hormone-receptor positivity, and higher HER2 positivity of breast cancers in our locality, which may be responsible for poor prognosis in our patients.
Pregnancy Loss: One Woman's Story of a Common Tragedy

Pregnancy and infant loss exact a devastating toll on the women and families who must endure this experience. Making the transition from a silent delivery room or nursery to a normal but changed life challenges the strongest among us. Physical, emotional, and economic issues may further complicate the recovery process. The silver lining in this experience is evident in frequent examples of medical professionals performing at their most caring best. While physicians may be driven by the reward of assisting in nature’s greatest successes, their compassion and empathy as fellow human beings are priceless when nature fails. This essay describes one woman’s experience with pregnancy loss and her perspective on moving forward.
Ovarian Volume And Antral Follicle Count Versus Serum FSH Measurement in Assessment of Ovarian Reserve

Background The presence of a wide range of tests of ovarian reserve suggests that no single test provides a sufficiently accurate result. Many tests are used without reference to an evidence base.So far, individual studies conducted on these tests are too small to give precise estimates of prognostic accuracy. Objective: The current study was designed to compare ovarian volume& antral follicle count (A.F.C) & day 3 FSH level, with respect to their ability to predict ovarian response of infertile women to ovulation induction agents Material and Methods: This is a prospective observational study in which 52 infertile women who were attending the Obst & Gynae Dept,PMCH UDAIPUR, were recruited. Blood samples were collected on day 2/day 3 for assessment of Se. FSH and TVS were done for antral follicle count and ovarian volume. Induction of ovulation was done for three successive cycles. Clomiphene citrate 100 mg 1OD was given from day 2 to 6, and patients were followed up with serial USG measurements for the dominant follicles (> or = 18 mm). Patients with no dominant follicle in the 1st cycle were subjected to the 2nd and 3 rd cycle of clomiphene 100 mg 1OD from day 2 to day 6 with Inj HMG 150 IU given i.m. starting from day 8 and every alternate day until at least one leading follicle attained ≥18 mm. Results: In this study the results showed that AFC has a higher predictability for successful induction i.e. when AFC < 10; the success rate was 17.7%, while when AFC > 10; the success rate was 57.142% which shows high significant difference.The next predicting factor was ovarian volume, when < 3 ml; the chance of success was very poor (zero), while when volume is 3-9 ml; the success rate was 44.11% & when volume >9 ml; the success rate was 62.5%. While day 3 FSH had the lowest predictability, when S.FSH < 10 m IU /ml; the success rate was 41.26%, while when FSH > 10 m IU / ml; the success rate was 33.33% which does not make much significant difference. Conclusion: We concluded from our study that antral follicle count and ovarian volume are effective predictors of ovarian response being superior to complex and time consuming endocrine tests.
Theoretical Approach to Predict the Size of Skyrmion

In the field of spintronics and information processing devices, magnetic skyrmions have been considered as promising candidates due to their unique properties. Because of the DMI, relatively small size skyrmions with diameter of only few nanometers have been discovered in recent studies. Also, they have a better stability compared to traditional magnetic bubbles. In perspective of the driven current density, extremely low value with order of 106 Am2 is observed compared to that for magnetic domain walls with order of 1012 Am2.
Endoscopic transcanal tympanoplasty: a case series

Background: Microscopes have ruled ear surgeries for years. The invention of endoscope and its use in otorhinolaryngology have become an important alternative for use. Importance of endoscope lies in giving the operating surgeon a wider exposure of the EAC and access in various hidden areas without need of a post auricular incision. Aim of this study is to analyze the outcome of endoscopic transcanal tympanoplasty. Methods: This prospective study was conducted in the Department of ENT, B.J. Medical College, Ahmedabad, from July 2015 to July 2017. Thirty patients with tympanic membrane perforation (tubotympanic type) were included in study. Patients were followed up for a mean duration of 12 months and the outcome was analyzed. Results: The patients included in the study ranged in the age group of 15-55 years. Out of them 16 were males and 14 were females. All of them underwent endoscopic transcanal tympanoplasty. 2 out of 30 patients had graft failure while others had good graft uptake. Overall success rate was 93.3%. Conclusions: Transcanal endoscopic tympanoplasty is highly successful, safe and less traumatic and thus can be used for ear surgeries.
Psychogenic Urinary Retention: A Case Report

Psychogenic retention of urine should be suspected in patient, who is unable to pass urine voluntarily, however without any discomfort and no urge to pass urine. It is a rare condition with minimal information known or reported in the literature. When no organic causes to decrease urine output can be found in patient with significant psychological stress, psychogenic retention of urine should be suspected. Noninvasive diagnostic methods can be done to rule out any organic pathology. Treatment usually consists of supportive psychotherapy and alleviating the trigger causing the condition.