Miracle-dz/UniFAR-FTUs huggingface dataset:
Die Effekte der Angiotensin II - Rezeptorblockade bei hypoxieinduzierter rechtsventrikulärer Hypertrophie in der Ratte

Es wurden die hamodynamischen, biochemischen und morphologischen Effekte einer Angiotensin-II-Rezeptorblockade mit dem AT1-Blocker Losartan auf eine hypoxie-induzierte rechtsventrikulare Hypertrophie an der Ratte untersucht. In weiblichen „Sprague Dawley“ Ratten wurde eine isolierte rechtsventrikulare Hypertrophie durch intermittierende Hypoxie hervorgerufen. Die intermittierende Hypoxie bewirkte einen Anstieg des rechtsventrikularen Drucks und eine Erhohung des Verhaltnisses von Ventrikelgewicht zu Korpergewicht im rechten Ventrikel, die Hypoxiebehandlung hatte keinen Einfluss auf die linksventrikularen Kreislaufparameter oder das Herzzeitvolumen. Die Aktivitaten der Glukose-6-Phosphat Dehydrogenase und der 6-Phosphoglukonat-Dehydrogenase waren nach der Hypoxiebehandlung im rechten Ventrikel erhoht, jedoch nicht im linken Ventrikel. In der Hypoxiegruppe ohne Losartan war das Zellvolumen der isolierten Kardiomyozyten erhoht, die Kardiomyozytenzellange unverandert, so dass man von einer hypoxieinduzierten rechtsventrikularen Hypertrophie vom primar konzentrischen Typ ausgehen muss. Losartan verringerte den hypoxie-induzierten Anstieg des rechtsventrikularen systolischen Druckes, die Zunahme des Verhaltnisses von rechtsventrikularem Gewicht zu Korpergewicht und die Enzymaktivitatserhohung signifikant, wenn auch nicht vollstandig. Die Zunahme des Volumens und der Querschnittsflache der isolierten Kardiomyozyten wurde durch Losartan jedoch vollkommen verhindert.
The reliability and diagnostic validity of clinical manifestations of catheter-associated urinary tract infection in hospitalized adults: A pilot study

Catheter-associated urinary tract infection is a common clinical condition among hospitalized patients with numerous health and economic implications. With judicious use of indwelling urinary catheters, along with strict adherence to basic infection prevention measures, such as hand hygiene and aseptic technique during catheter insertion, these infections are most often preventable. However, these devices continue to be used inappropriately or unnecessarily, which has led the Center for Medicare and Medicaid Services (CMS), the Centers for Disease Control and Prevention (CDC), and numerous infectious disease professional societies to focus attention on how these infections can be diagnosed, prevented, and managed. Despite these efforts, consensus on how best to identify cases of CAUTI has been elusive. Perhaps the most widely used guidelines for the diagnosis, prevention, and treatment of CAUTI are those published in 2010 in the American Journal of Infection Control by Hooton and colleagues. These authors are very clear that CAUTI is a problem if, and only if, it is associated with clinical manifestations; the presence of urinary microorganisms alone is not a clear indication for antimicrobial therapy. Moreover, these authors provide a list of accepted clinical manifestations of CAUTI, which are substantially different from those in previous guidelines. Among others, the manifestations listed include: fever, suprapubic tenderness, flank tenderness, and delirium. However, these are supported by expert opinion only, and neither their diagnostic validity nor their inter-rater reliability have been reported in the literature. The purpose of this study was to test the feasibility of methods to examine the diagnostic validity and inter-rater reliability of fever, suprapubic tenderness, flank
Hurricanes Enhance Labile Carbon Export to the Deep Ocean

Tropical cyclones (hurricanes) generate intense surface ocean cooling and vertical mixing resulting in nutrient upwelling into the photic zone and episodic phytoplankton blooms. However, their influence on the deep ocean remains unknown. Here we present evidence that hurricanes also impact the ocean's biological pump by enhancing export of labile organic material to the deep ocean. In October 2016, Category 3 Hurricane Nicole passed over the Bermuda Time Series site in the oligotrophic NW Atlantic Ocean. Following Nicole's passage, particulate fluxes of lipids diagnostic of fresh phytodetritus, zooplankton, and microbial biomass increased by 30–300% at 1,500 m depth and 30–800% at 3,200 m depth. Mesopelagic suspended particles following Nicole were also enriched in phytodetrital material and in zooplankton and bacteria lipids, indicating particle disaggregation and a deepwater ecosystem response. Predicted climate‐induced increases in hurricane frequency and/or intensity may significantly alter ocean biogeochemical cycles by increasing the strength of the biological pump.
Occupation and injuries: risk factors for preterm delivery

Preterm delivery (PTD) is a leading cause of infant death, and surviving infants are at risk for poor health. Data from the Iowa Health in Pregnancy Study, a case-control study of maternal stress on risk of PTD and small for gestational age (SGA) deliveries were used to address three aims: 1) develop a method to correct for error in ultrasound measurement among suspected SGA infants, 2) estimate the association of occupational stress on risk of PTD, and 3) examine injury-related risk factors for PTD. Estimates of gestational age using ultrasound can be biased if the fetus is growthrestricted, yielding underestimates due to the small stature of the fetus. Multivariate linear regression modeling was used to estimate and correct for this bias among subjects with a suspected SGA infant who 1) began prenatal care in the first trimester, 2) reported a last menstrual period and 3) had an ultrasound examination between 7-21 weeks. To correct for this bias, an average of 1.5 weeks was added to the ultrasound gestational age. Following the correction, the proportion of PTD cases decreased from 29.1% to 26.5% while SGA cases increased from 23.7% to 31.3%. Using this PTD classification, occupational physical and psychosocial stressors were studied. Continuous employment over the first 20 weeks of pregnancy was associated with a 30% increased risk of PTD versus not working. Working women reporting highly repetitive tasks (aOR=1.47(1.10-1.98)) or inadequate breaks (aOR=1.67(1.03-2.73)) were at increased risk of PTD. Working women who reported high lifting in the home had double the risk of PTD. Over 5% of control subjects reported an injury during pregnancy, and injured women tended to be younger, unmarried, less educated, and have lower incomes. Women with injuries involving >1 body part (aOR=2.50(1.14-5.49)), or injuries to the abdomen and other regions of the body (OR=1.75(0.59-5.23)) were at increased risk of PTD.
Unintended Thai adolescent pregnancy: A grounded theory study

Abstract UNINTENDED THAI ADOLESCENT PREGNANCY: A GROUNDED THEORY STUDY Wanwadee Neamsakul University of California, San Francisco, 2008 The purpose of this grounded theory was to discover the social processes used by Thai adolescents with unintended pregnancies throughout the childbearing year. Twenty Thai adolescents with an unintended pregnancy, between 14-19 years old, enrolled between 24-28 weeks while receiving prenatal care clinic at Uttaradit Hospital, Thailand. Semi-structured interviews were conducted at 3 different points during pregnancy through 8-12 weeks postpartum. "Kwa ja ru diang sa: A life journey of Thai adolescents from unintended pregnancy to motherhood" was identified as the basic social psychological process for adolescents who decided to carry an unintended pregnancy. The process was shaped within the contexts of family, life styles and values, traditions, religion, education, gender roles, and law. The life journey began with "surrender (Yom jum non) to an unintended pregnancy" and which reflected the causal conditions. It started in the chronological order of events during pregnancy. "Preparation to become a new mother" comprised the action/interaction strategies used to cope with changes during pregnancy. "Support from their close circle is like nourishment for their soul (Yad nam tip chalom jai) and which gets them through difficult time (Tee peung yam yak)," were the intervening conditions that helped facilitate and balance the strategies used to cope with changes during pregnancy on the journey to motherhood. The journey ended with "Adolescent mom: I can do this mission. " which described the consequences of the use of different strategies and the support from people surrounding them. Needs and sources of support during pregnancy and transition to motherhood were identified. Specific strategies for clinicians and research questions were also identified. These findings held potential to inform the health care community on how best to meet the adolescents' needs during pregnancy and to foster them as new mothers.
Birds of Parque Estadual do Tainhas, an important protected area of the highland grasslands of Rio Grande do Sul, Brazil

Parque Estadual do Tainhas – PET (Tainhas State Park) is a protected area with significant extensions of natural grasslands located in highland grasslands of northeastern Rio Grande do Sul state, Brazil, and recognized as an Important Bird Area. Our aim was to record the bird species richness of PET with a greater sampling effort than previous studies at the site, including unpublished data such as occurrence status of most species and evidence of breeding of some of them in the park. We surveyed birds between 2012 and 2018 performing aleatory trails covering mainly the central portion of PET (1,500 ha). We also added records from published studies. We listed 208 species, of which 203 were recorded during our fieldwork (including 18 species of conservation concern). The estimated richness was 222.22 (SD = 10.91) species, according to Jackknife 1 method. This result represents a 58% increase in the species richness of the park and shows that long-term monitoring of the bird community allows to access more accurate richness and to identify the regular species (core avifauna) of the park. The presence of 55 breeders and threatened species shows the importance of this protected area for breeding and conservation of grassland birds, such as Urubitinga coronata, Cinclodes pabsti, Xolmis dominicanus, Anthus nattereri, Xanthopsar flavus, and Sporophila melanogaster.
Ovda Fluctus, the Festoon Lava Flow on Ovda Regio, Venus: Not Silica‐Rich

Ovda Fluctus (6.1°S, 95.5°E) is a lava flow complex on the equatorial tessera highlands of Ovda Regio, Venus. We examined its morphology and geologic setting to determine if its apparent emplacement rheology is consistent with silica‐rich (e.g., rhyolitic) lava; this has significant implications for the compositions of Venus's tesserae. Using Magellan radar data, we find that the radar properties (emissivity, roughness, and backscatter) of Ovda Fluctus are similar to those of the surrounding tessera, although the flow is smoother at multiple scales. Ovda Fluctus is a “festoon flow complex,” whose surface is rumpled into arcuate folds. The flow includes multiple flow lobes and at least two distinct flow units. The flow complex includes a portion at high altitude (~5 km above mean planetary radius) that has low radar backscatter and high radar emissivity compared with lower‐altitude portions of the complex. The high‐altitude region of Ovda Fluctus is continuous with the lower‐elevation portions: the change in radar properties does not represent different flows. Outlines of Ovda Fluctus flow lobes have fractal dimensions consistent with basaltic pahoehoe lavas. The margin of Ovda Fluctus is at significantly higher elevation than its center, a characteristic seen in basalt flows on Earth, but not on more silica‐rich flows. Thus, the available evidence suggests that Ovda Fluctus had an emplacement rheology consistent with a basaltic composition; this result provides no support for hypotheses that Ovda Regio (a highlands tessera terrain) is composed of granitic rock.
Equatorial Pacific Variability in Climate Models

A long-standing difficulty of climate models is to capture the annual cycle (AC) of eastern equatorial Pacific (EEP) sea surface temperature (SST). In this study, we first examine the EEP SST AC in a set of integrations of the coupled Kiel Climate Model (KCM) in which only atmosphere model resolution differs. When employing coarse horizontal and vertical atmospheric resolution, significant biases in the EEP SST AC are observed. These are reflected in an erroneous timing of the cold tongue’s onset and termination as well as in an underestimation of the boreal spring warming amplitude. A large portion of these biases are linked to a wrong simulation of zonal surface winds, which can be traced back to precipitation biases on both sides of the equator and an erroneous low-level atmospheric circulation over land. Part of the SST biases also is related to shortwave radiation biases related to cloud cover biases. Both wind and cloud cover biases are inherent to the atmospheric component, as shown by companion uncoupled atmosphere model integrations forced by observed SSTs. Enhancing atmosphere model resolution, horizontal and vertical, markedly reduces zonal wind and cloud cover biases in coupled as well as uncoupled mode
Review and assessment of offshore renewable energy resources in morocco’ coastline

Abstract Modern Morocco’s heavy dependence on foreign energy imports, combined with a rapidly growing population and an increasing demand for a better quality of life, makes the country’s future uncertain. Possessing rich and diversified renewable energy resources within its territory encouraged the Moroccan government to make ambitious plans to integrate renewable energy resources into its national grid on a big scale, 42% of its energy generating capacity from renewables by 2020, and 52% by 2030. This paper provides a first assessment of the offshore energy potential available near the coastline of Morocco. After a brief description of operations of offshore wind, tidal and wave power, a first order assessment of their potential is presented and discussed. This study shows that important offshore wind resources are available throughout the Mediterranean and the Atlantic coast of Morocco. This resource peaks between the regions of Al Jadida and Agadir, reaching a speed of 9_m/s. The bulk of the offshore resources are located at the Atlantic coastline of the country. Tidal stream resources are concentrated at the region of Tangier, where tidal speed is up to 1.9_m/s potentially producing 1. 58_kW/m2. Oualidia lagoon was studied and found to be capable of producing more than 0. 5_MW of electricity if a tidal barrage exploits 10% of its surface. Finally, ocean wave energy is available all over the Atlantic coastline and peaks between the regions of Essaouira and Agadir where the wave heights are between 1.9 and 2. 13_m.
Secondary Organic Aerosol Formation from Healthy and Aphid-Stressed Scots Pine Emissions

One barrier to predicting biogenic secondary organic aerosol (SOA) formation in a changing climate can be attributed to the complex nature of plant volatile emissions. Plant volatile emissions are dynamic over space and time, and change in response to environmental stressors. This study investigated SOA production from emissions of healthy and aphid-stressed Scots pine saplings via dark ozonolysis and photooxidation chemistry. Laboratory experiments using a batch reaction chamber were used to investigate SOA production from different plant volatile mixtures. The volatile mixture from healthy plants included monoterpenes, aromatics, and a small amount of sesquiterpenes. The biggest change in the volatile mixture for aphid-stressed plants was a large increase (from 1.4 to 7.9 ppb) in sesquiterpenes—particularly acyclic sesquiterpenes, such as the farnesene isomers. Acyclic sesquiterpenes had different effects on SOA production depending on the chemical mechanism. Farnesenes suppressed SOA formation from ozonolysis with a 9.7–14.6% SOA mass yield from healthy plant emissions and a 6.9–10.4% SOA mass yield from aphid-stressed plant emissions. Ozonolysis of volatile mixtures containing more farnesenes promoted fragmentation reactions, which produced higher volatility oxidation products. In contrast, plant volatile mixtures containing more farnesenes did not appreciably change SOA production from photooxidation. SOA mass yields ranged from 10.8 to 23.2% from healthy plant emissions and 17.8–26.8% for aphid-stressed plant emissions. This study highlights the potential importance of acyclic terpene chemistry in a future climate regime with an increased presence of plant stress volatiles.
Accidentes de circulación: impacto en un Registro de Trauma Infantil en la Comunidad Autónoma de Galicia

Objetive: To assess the impact of traffic accidents in a regional pediatric trauma registry (PTR). Methods: During 2009 we collected data prospectively, systematic, multi-hospital, in a secure Web database from 398 patients, 66% male, mean age 7 years, and mean weight 30 kg. Of this group received 53% prehospital care and by medical personnel only 38,5%. Inclusion criteria: pediatric patient admited at hospital by accident. Results: Transfer in non medicalised ambulance in 30,8%, medicalized in 13,8%, passenger car in a 53,8% or even walking at 1,5%. Those who were taken by ambulances to a 38,5% had no intravenous and 77,6% did not bring a cervical collar. Of the car moved, 6,4% came with ITP <8 (Pediatric Trauma Index). In car accidents, children had no restraint in 62.5%, and the motorcycle, 30% not wearing a helmet. Most affected systems, highlights the locomotor 61,5% and the craniofacial area with 58%. In the study of the site highlights the city, 73%, and the highway, 20% of the total. For slots, the majority of accidents occurred between 17 and 20 hours. Conclusions: The RTP shows a bleak picture in terms of initial support to pediatric trauma is concerned, and specifically in road accidents
Detailed Balance Analysis of Photovoltaic Windows

There are a number of technical and socio-economic factors converging to position photovoltaic (PV) windows as a transformative technology for the energy landscape of the future: 1) Urban areas currently account for 67–76% of global final energy consumption. 2) 70% of the world’s population will live in urban areas by 2050. 3) The overwhelming architectural trend is away from opaque building components and toward all-glass facades. 4) Photovoltaics are becoming extremely affordable, and the most expensive components in a conventional module are the glass and transparent metals—components that are already in highly-insulating glazing. 5) Buildings are increasingly built to easily integrate with photovoltaic energy generation using DC microgrids and on-site energy generation to balance high demand on the grid. Rational design of PV windows is of paramount importance to realize their impact. In this work, we provide an analysis on the theoretical performance of PV windows using a detailed balance model to understand the complex design space of power conversion efficiency, visible light transmittance, solar heat gain coefficient, and color. We find there are two distinct regimes for PV window absorber design. The first lowvisible light transmittance regime validates the most prevalent approach to semitransparent PV windows in which conventional absorber materials (Si, CIGS, CdTe, CZTS, perovskite, etc.) are thinned to allow visible light to pass through. In this thinned-absorber regime, an ideal bandgap of ~1.35 eV maximizes performance, which is consistent with the famous Shockley–Queisser limit. However, we identify a second, high visible light transmittance regime in which the ideal bandgap for maximum power conversion efficiency increases monotonically from 2 to 3 eV with increasing visible light transmittance. In this tuned-bandgap regime, the solar cell exhibits lower losses and tunable solar heat gain and color.
The North Pacific Pacemaker Effect on Historical ENSO and Its Mechanisms

Studies have indicated that North Pacific sea surface temperature (SST) variability can significantly modulate El Niño–Southern Oscillation (ENSO), but there has been little effort to put extratropical–tropical interactions into the context of historical events. To quantify the role of the North Pacific in pacing the timing and magnitude of observed ENSO, we use a fully coupled climate model to produce an ensemble of North Pacific Ocean–Global Atmosphere (nPOGA) SST pacemaker simulations. In nPOGA, SST anomalies are restored back to observations in the North Pacific (>15°N) but are free to evolve throughout the rest of the globe. We find that the North Pacific SST has significantly influenced observed ENSO variability, accounting for approximately 15% of the total variance in boreal fall and winter. The connection between the North and tropical Pacific arises from two physical pathways: 1) a wind–evaporation–SST (WES) propagating mechanism, and 2) a Gill-like atmospheric response associated with anomalous deep convection in boreal summer and fall, which we refer to as the summer deep convection (SDC) response. The SDC response accounts for 25% of the observed zonal wind variability around the equatorial date line. On an event-by-event basis, nPOGA most closely reproduces the 2014/15 and the 2015/16 El Niños. In particular, we show that the 2015 Pacific meridional mode event increased wind forcing along the equator by 20%, potentially contributing to the extreme nature of the 2015/16 El Niño. Our results illustrate the significant role of extratropical noise in pacing the initiation and magnitude of ENSO events and may improve the predictability of ENSO on seasonal time scales.
Excess phosphorus from compost applications in urban gardens creates potential pollution hotspots

Urban sustainability initiatives often encompass such goals as increasing local food production, closing nutrient loops through recycling organic waste, and reducing water pollution. However, there are potential tradeoffs among these desired outcomes that may constrain progress. For example, expansion of urban agriculture for food production may create hotspots of nutrient pollution if nutrient recycling is inefficient. We used gardener and urban farmer survey data from the Twin Cities Metropolitan Area (Minnesota, USA) to characterize phosphorus (P) and nitrogen (N) inputs and harvest in order to determine nutrient use efficiencies, and measured soil P concentrations at a subset of these sites to test whether excess soil P was common. All survey respondents (n = 142) reported using some form of soil amendment, with plant-based composts being the most common. Median application rates were 300 kg P/ha and 1400 kg N/ha. Median nutrient use efficiencies were low (2.5% for P, 5.0% for N) and there was only a weak positive relationship between P and N inputs and P and N harvested in crop biomass. Garden soils had a median Bray P value of 80 ppm, showing a buildup of plant-available P far exceeding recommended levels. Our results show that urban gardens are characterized by high nutrient inputs and inefficient conversion of these nutrients into crops, leading to buildup and potential loss of P and N from garden soils. Although urban gardens make up only 0.1% of land area in the Twin Cities, compost application to these urban gardens still constitutes one of the largest inputs of P to the watershed. In order to maximize desired outcomes from the expansion of urban agriculture (UA), it will be necessary to target soil amendments based on soil nutrient levels and crop nutrient demand.