Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute Respiratory Distress Syndrome after Rituximab Infusion

Rituximab, a humanized monoclonal antibody approved for malignant lymphoma, is being increasingly, effectively, and safely used for immune thrombocytopenic purpura (ITP) and other humoral autoimmune disorders. We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab. Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation. Progressive hypoxemia mandated endotracheal intubation 1 week after rituximab administration and led to death 4 weeks after admission. ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines. ARDS is rarely associated with rituximab infusion for lymphoproliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.
Histamine activates Cl‐ and K+ currents in guinea‐pig tracheal myocytes: convergence with muscarinic signalling pathway.

1. We investigated the effects of histamine on membrane currents and contractile state of isolated guinea‐pig tracheal myocytes using perforated patch and whole‐cell recording techniques. The effects of histamine were compared to those of acetylcholine (ACh) and caffeine. 2. During voltage clamp (Vhold = ‐60 mV), histamine elicited contraction and an inward current (Ihist) which was often followed by current oscillations. Ihist had a reversal potential (Vrev) of ‐9 +/‐ 3 mV. 3. Ihist was dependent on the Cl‐ gradient and was antagonized by the Cl‐ channel blocker niflumic acid. Vrev was more positive (+2 +/‐ 1 mV) when K(+)‐selective currents were blocked by Cs+ and TEA. When all external Na+ was replaced with N‐methyl‐D‐glucamine, there was a small reduction in the amplitude of Ihist. 4. The histamine‐induced current was similar to that elicited by ACh and by caffeine with respect to time course, amplitude, and current‐voltage relationship. Responses to histamine and to ACh were non‐additive, consistent with a convergence of histaminergic and cholinergic signalling pathways. Ihist was antagonized by the H1 histaminergic receptor antagonist astemizole, but not by atropine. 5. When recorded using the perforated patch configuration, Ihist could be elicited repeatedly for more than 30 min. When cells were studied in the whole‐cell configuration using a pipette solution containing 0.025 mM EGTA, the amplitude of Ihist was initially the same as that obtained using perforated patch but then decreased; the time required for the responses to decrease to 50% (t1/2) was 8.2 +/‐ 1.0 min. When 1 mM EGTA was included in the pipette solution (whole‐cell configuration), the initial response to histamine was significantly decreased in size and t1/2 was reduced to 3.3 +/‐ 0.7 min. 6. The characteristics of the signalling pathway were examined in cells studied using the whole‐cell configuration with 0.025 mM EGTA in the recording pipette. Heparin significantly reduced t1/2 to 4.3 +/‐ 0.8 min. GTP gamma S elicited inward current and oscillations; both effects were enhanced by histamine. GTP gamma S also reduced t1/2 to 1.4 +/‐ 0.1 min. Pertussis toxin did not alter the amplitude or time course of Ihist. 7. We conclude that in guinea‐pig tracheal myocytes, binding of histamine to H1 receptors leads to release of Ca2+ from intracellular stores and subsequent activation of Cl‐ and K+ conductances as well as contraction. Furthermore, we demonstrate that ACh elicits similar physiological responses due to a convergence of the histaminergic and muscarinic signalling pathways.
Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006.

BACKGROUND Hemolytic uremic syndrome (HUS) is a life-threatening illness usually caused by infection with Shiga toxin-producing Escherichia coli O157 (STEC O157). We evaluated the age-specific rate of HUS and death among persons with STEC O157 infection and the risk factors associated with developing HUS. METHODS STEC O157 infections and HUS cases were reported from 8 sites participating in the Foodborne Diseases Active Surveillance Network during 2000-2006. For each case of STEC O157 infection and HUS, demographic and clinical outcomes were reported. The proportion of STEC O157 infections resulting in HUS was determined. RESULTS A total of 3464 STEC O157 infections were ascertained; 218 persons (6.3%) developed HUS. The highest proportion of HUS cases (15.3%) occurred among children aged <5 years. Death occurred in 0.6% of all patients with STEC O157 infection and in 4.6% of those with HUS. With or without HUS, persons aged 60 years had the highest rate of death due to STEC O157 infection. Twelve (3.1%) of 390 persons aged 60 years died, including 5 (33.3%) of 15 persons with HUS and 7 (1.9%) of 375 without. Among children aged <5 years, death occurred in 4 (3.0%) of those with HUS and 2 (0.3%) of those without. CONCLUSIONS Young children and females had an increased risk of HUS after STEC O157 infection. With or without HUS, elderly persons had the highest proportion of deaths associated with STEC O157 infection. These data support recommendations for aggressive supportive care of young children and the elderly early during illness due to STEC O157.
Sensorless Drives in Industrial Applications

The changes in the market of motor drives over the last few years, especially the wish to complete the portfolio toward the satisfaction of most of the customer needs, have brought a new thrust in the area of drives and have favored the realization of procedures that were known from academic discussion. Under certain conditions, the injection sensorless control schemes that exploit the anisotropy of the AC machine and inject a test signal are now found in drives with permanent magnet synchronous machine, while the fundamental wave procedures seem to be the most common solution in the case of induction machines. In this paper, different aspects regarding the state of the art of sensorless drives in industrial applications and the reasons that determine the acceptance or refusal of the different solutions on the side of manufacturers of motor drives are explained and discussed.
Evaluating the performance of open source software projects using data envelopment analysis

Purpose – The purpose of this paper is to develop and test a model of the relative performance of open source software (OSS) projects.Design/methodology/approach – This paper evaluates the relative performance of OSS projects by evaluating multiple project inputs and multiple project outputs by using a data envelopment analysis (DEA) model. The DEA model produces an efficiency score for each project based on project inputs and outputs. The method of producing an efficiency score is based on the convex envelopment technology structure. The efficiency measure quantifies a “distance” to an efficient frontier.Findings – The DEA model produced an index of corresponding intensities linking an inefficient project to its benchmark efficient project(s). The inefficiency measures produced an ordering of inefficient projects. Eight projects were found to be “efficient” and used as benchmarking projects.Research limitations/implications – This research is limited to only security‐based OSS projects. Future research o.
POINTER correctly estimates the transmission probabilities under the general transmission model in the case of incomplete selection.

Using the computer program POINTER under the general transmission model, an estimation of the parameter values of the dominance parameter (d), the distance between two homozygous mean effects (t), and the frequency of a deleterious allele (q) were obtained. They were equal to those of the generating model. Estimation of the transmission probabilities gave 1, . 5, and 0. The transmission probability estimations are valid using POINTER under the general transmission model when the selection of families is not complete.
Curriculum optimisation via evolutionary computation, for a neural learner robust to categorical adversarial samples

In this paper we evolve curricula for improving the training accuracy of an agent that learns under the influence of adversarial alteration of training data, since adversarial influence is highly likely to be encountered in many defence and security operations. We consider categorical adversarial influence, where a fraction of the training samples is intentionally labelled with erroneous categories in order to misguide the learner towards malicious outcomes that jeopardise the mission success. Thus, we consider a supervised learning agent in the form of a deep convolutional neural network which learns to classify handwritten digits from 0 to 9, and we use a mutation-only genetic algorithm that evolves the sequence of the data samples in the training set (including the adversarial samples) in order to mitigate the influence of the adversarial samples on learning accuracy. We demonstrate that the genetic algorithm is able to obtain optimal curricula that provide the learner with the capability to perform well even when 20% of the training data are erroneously labelled.
Lipospheres: Emerging Carriers in the Delivery of Proteins and Peptides

Currently, drug delivery technologies for protein and peptide delivery mainly rely on biodegradable polymers. However, protein stability during release from these systems can be critical due to physical and chemical instabilities. Lipospheres are solid microparticles composed of fat core stabilized by phospholipids layer represent an alternative carrier for the delivery of highly challenging, labile and unstable substances. This review highlights various aspects of lipospheres like physicochemical characteristics and stability for better clinical utility with a wider spectrum of proteins and peptides.
Nd:YAG laser ablation of the prostate as a treatment for benign prostatic hypertrophy

Many techniques have been used to relieve obstructive symptoms associated with benign prostatic hypertrophy. Transurethral resection of the prostate (TURP) with an electrocautery loop is the most commonly performed operation to relieve bladder neck and urethral obstruction caused by prostatic adenoma. There is increased interest in alternative therapies to reduce prostatic size for symptom relief in this condition. We describe a technique using the neodymium:YAG (Nd:YAG) laser and a 600‐μm laser quartz fibre with an attached terminal gold‐plated metal alloy reflector to provide reliable deep penetration into prostatic tissue for prostatic adenoma ablation. We report the first use of this technique in three patients with benign prostatic obstruction and one with localised adenocarcinoma of the prostate. © 1992 Wiley‐Liss, Inc.
Learning to in complement constructions

ABSTRACT The acquisition of to in infinitive complement structure was examined in the spontaneous speech data from four children, who were observed longitudinally from two to three years of age. The children learned to as a complementizer connective in the context of a small group of verbs and other matrix forms that take a verb phrase complement. They did not learn to in the context of the complement verbs to mark the infinitive. Secondly, the children learned to with the meaning ‘direction towards’ and not as a meaningless syntactic marker. These results contribute to understanding the relation between the acquisition of complex syntax and the verb system in child language, and to evaluating traditional and contemporary linguistic theories of infinitive complement structure in English.
High Prevalence of Subclinical Mastitis and Multidrug Resistant Staphylococcus aureus Are a Threat to Dairy Cattle Production in Kiboga District (Uganda)

Subclinical mastitis (SCM) is one of the major factors affecting the productivity of dairy cattle all over the world. This study established the burden of SCM and determined the potent antibacterial formulation for control of Staphylococcus aureus (SA) related SCM in selected dairy cattle farms in Kiboga district. A total of 124 dairy cattle from 12 farms were screened for SCM using California Mastitis Test (CMT) from Kiboga Town-Council, Kapeke and Lwamata sub-counties. The offending bacteria were cultured and the antibiogram of SA was carried out using antibacterial susceptibility by the modified Kirby-Bauer disc diffusion method. Additional qualitative data on the factors that predispose cows to SCM was obtained through questionnaires and observation of milking Practice. The prevalence of SCM in the three sub-counties was 87.9%. Over 70% of the dairy cattle screened for SCM had more than 2 udder quarters affected. The majority (90%) of SCM was caused by mixed bacterial infections: Coagulase negative staphylococci (64.4%) and SA (16.6%) being the most prevalent. All the farmers (100%) lacked knowledge on SCM, udder towels, teat dipping and drug cow therapy. Overall, 71.4% of SA isolated was multi-drug resistant. There was a high level of resistance against penicillin (100%), neomycin (85.7%) and tetracycline (71.4%). In contrast, all the above isolates were susceptible to Trimethoprim-Sulphamethazole. In conclusion, the high burden of SCM and emergence of multidrug resistant SA are one of the constraints to dairy production in Kiboga district. Therefore, sensitization of dairy farmers in Kiboga district on proper hygienic, appropriate milking techniques and dry cow therapy using potentiated sulfonamide intra-mammary preparations are highly recommended in SA associated SCM.
Health risk assessment of exposure to selected volatile organic compounds emitted from an integrated iron and steel plant

Workplace air samples from sintering, cokemaking, and hot and cold forming processes in the integrated iron and steel industry were analyzed to determine their volatile organic compound (VOC) concentration. Sixteen VOC species including three paraffins (cyclohexane, n-hexane, methylcyclohexane), five chlorinated VOC species (trichloroethylene, 1,1,1-trichloroethane, tetrachloroethylene, chlorobenzene, 1,4-dichlorobenzene), and eight aromatics (benzene, ethylbenzene, styrene, toluene, m,p-xylene, o-xylene, 1,2,4-trimethylbenzene, 1,3,5-trimethylbenzene) were selected to measure their noncancer risk for workers. Concentrations of toluene, xylene, 1,2,4-trimethylbenzene, 1,3,5-trimethylbenzene, dichlorobenzene, and trichloroethylene were high in all four processes. Carbon tetrachloride and tetrachloroethylene concentrations were high in the hot and cold forming processes. The noncancer risk followed the increasing order: cokemaking > sintering > hot forming > cold forming. 1,2,4-trimethylbenzene and 1,3,5-trimethylbenzene contributed 44% to 65% and 13% to 20% of noncancer risk, respectively, for the four processes. Benzene accounted for a high portion of the noncancer risk in cokemaking. The hazard index (HI: 17–108) of the average VOC concentrations suggests that health risks can be reduced by improving workplace air quality and protecting workers.
MICRO UAV BASED GEOREFERENCED ORTHOPHOTO GENERATION IN VIS+NIR FOR PRECISION AGRICULTURE

This paper presents technical details about georeferenced orthophoto generation for precision agriculture with a dedicated selfconstructed camera system and a commercial micro UAV as carrier platform. The paper describes the camera system (VIS+NIR) in detail and focusses on three issues concerning the generation and processing of the aerial images related to: (i) camera exposure time; (ii) vignetting correction; (iii) orthophoto generation.
Fluidic Self-Assembly of Nanowires

In recent years, the scaling of microelectronic, photonic and micro-electromechanical systems (MEMS) to the 50-500 nm length scale has challenged the capability of conventional micro-fabrication technologies in the cost-effective, mass production of devices and integrated systems [1]. There is an increasing need to develop new nano-fabrication technologies to address the challenges of decreasing dimensions, in order to enable the era of nanotechnology [2].
Explaining SLDNF resolution with non-normal defaults

This paper defines a defauit iogic interpretation for normai programs thiat hias the foilowing major characteristics. First, it directiy captures the true nature of SLDNF resoiution as an extension of SLD resoiution. Second, it is semanticaliy convincing, but it requires neither an elaborated nonstandard interpretation nor a radical rewriting of the program clauses that would maice it difficult to understand their meaning. Last, it extends known results for stratified normal programs to programs that satisfy a weaker condition.
Bimodal biometric system based on SIFT descriptors of hand images

Hand shape biometry is among the most popular biometrics employed to characterize a person in forensic applications, due to its simplicity of use and acceptance of individuals. However, this modality presents weaknesses which may make system inaccurate. In fact, people from the same family or twins may have related hand features. Therefore, the performance of the hand verification process depends highly on the hand descriptors. In this paper, we propose a new approach for personal verification combining hand shape and palmprint features extracted using the Scale Invariant Feature Transform (SIFT). This transform was improved its high distinction and efficiency in many applications especially in object recognition and video tracking. Our experiments on IITD hand database demonstrate promising results by fusing at matching level score the hand shape and palmprint modalities. These results are comparable with similar bimodal identification methods.
Design of a 8×8 stripline butler matrix with beam steering capability

A 8times8 steerable Butler matrix has been designed, fabricated and tested using a stripline-based multi-layer structure. The circuit is very compact and shows a 50% operation bandwidth at 2.4 GHz. The functionality of the butler matrix is enhanced by adopting the reflection-type phase shifters so that it is capable to adjust the beam direction with high angular resolution. The experimental results show a good agreement with the simulation predictions. Due to page constraints, more measurement results will be shown during the presentation of this work.
Ultrastructural Analysis of Megakaryocytes in GPV Knockout Mice

Summary Lesions in the genes for GPIbα, GPIbβ or GPIX result in a bleeding diathesis, the Bernard-Soulier syndrome (BSS), which associates a platelet adhesion defect with thrombocytopenia, giant platelets and abnormal megakaryocytes (MK). The role of GPV, also absent in BSS, was recently addressed by gene targeting in mice. While a negative modulator function for GPV on thrombin-induced platelet responses was found in one model, the absence of GP V had no effect on GPIb-IX expression or platelet adhesion. Our study extends previous results and reports that electron microscopy of bone marrow from the GPV knockout mice revealed a normal MK ultrastructure and development of the demarcation membrane system (DMS). There was a usual presence of MK fragments in the bone marrow vascular sinus. Immunogold labelling of MK from the knockout mice showed a normal distribution of GPIb-IX in the DMS and on the cell surface. The distribution of fibrinogen, vWF and P-selectin was unchanged with, interestingly, P-selectin also localised within the DMS in both situations. Thus GPV is not crucial to MK development and platelet production, consistent with the fact that no mutation in the GPV gene has as yet been described in BSS.
Selective modulation of microglial signal transduction by PACAP

We have investigated the possible effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on signal transduction pathways associated with inflammatory activation of BV-2 mouse microglia cells. Pretreatment of the cells with PACAP resulted in a significant decrease in LPS- or IFN&ggr;-induced NO production as well as iNOS and IL-1&bgr; mRNA levels. The inhibitory effect of PACAP appeared to be mediated through an increase in intracellular cAMP. PACAP inhibition of LPS-induced NO production was accompanied by inhibition of p38 MAPK activation, but not ERK, JNK, or NF-κB. IFN&ggr;-induced STAT-1 activation or IRF-1 induction was not significantly influenced by PACAP. Therefore, PACAP appears to suppress inflammatory activation of BV-2 microglia via specific inhibition of LPS-induced p38 MAPK pathway.
An Association Rule Mining Algorithm Based on a Boolean Matrix

Association rule mining is a very important research topic in the field of data mining. Discovering frequent itemsets is the key process in association rule mining. Traditional association rule algorithms adopt an iterative method to discovery, which requires very large calculations and a complicated transaction process. Because of this, a new association rule algorithm called ABBM is proposed in this paper. This new algorithm adopts a Boolean vector "relational calculus" method to discovering frequent itemsets. Experimental results show that this algorithm can quickly discover frequent itemsets and effectively mine potential association rules.
Tel/Aml1 Fusion is Not a Prognostic Factor in Dutch Childhood Acute Lymphoblastic Leukaemia

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A Broadband $L$ -Strip Fed Printed Microstrip Antenna

A broadband <;i>;L<;/i>; -strip fed printed microstrip antenna is presented. The strip loaded slotted broadband microstrip antenna is fed by an L-strip feed line to achieve impedance matching for the higher order modes of the patch antenna in addition to the existing resonances. The antenna offers 74% bandwidth when printed on a substrate of dielectric constant 4.2 and has an overall dimension of 42 × 55 × 3.2 mm3. The simulated and experimental reflection characteristics of the antenna with and without the L-feed along with radiation patterns, input impedance variations, gain and efficiency of the final antenna are presented and discussed. The time domain transient analysis indicates a minimum dispersion to the transmitted pulse.