Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of patients with myocardial infarction and hypertension.

A patient presenting with acute myocardial infarction and severe or uncontrolled hypertension represents an emergency situation requiring prompt and accurate evaluation of both conditions, and treatment should be neither inadequate nor overzealous. The acute coronary event may be accompanied by raised blood pressure either due to acute stress or secondary to long-standing but possibly undiagnosed hypertension. Very rarely, such a presentation may be part of a true hypertensive emergency, such as malignant phase hypertension, hypertensive encephalopathy or dissection of the aorta. Whilst both myocardial infarction and uncontrolled hypertension require treatment, the question is not only ‘what should I use to lower the pressure’ but also ‘how much time do I have in order to obtain the potential benefit from thrombolytic treatment’; indeed immediate and rapid normalization of blood pressure is not the goal of initial therapy in most cases. Treating one condition but not the other also creates potential problems. For example, giving thrombolytic therapy to a patient with severe hypertension may increase the risk of cerebral bleeding. By contrast, treating the hypertension alone and ignoring the heart attack may result in complications secondary to myocardial infarction, including severe cardiac dysfunction, arrhythmias and valve dysfunction. This has led to some debate and confusion over the management of such patients, leading to suboptimal care and different treatment policies in different coronary care units. Some of the treatments that are being employed have even been shown to be dangerous.
Contribution à l'étude théorique des interactions entre combustion et rayonnement

Cette these presente l'etude theorique (au moyen des developpements asymptotiques raccordes) de trois classes de problemes de combustion des premelanges heterogenes ou le role thermique du rayonnement est important. Il est d'abord montre analytiquement que l'addition de particules solides inertes permet d'etendre les limites de propagation dans des tubes des flammes de poussieres reactives (e. G. Charbon) et d'air et que la prise en compte de transports turbulents peut ralentir ces flammes. Ensuite, sont abordes les problemes d'ignition. Pour un demi-espace plan reactif soumis a un flux radiatif a sa surface, le temps d'ignition est obtenu en fonction de la reactivite du milieu. De plus, la mise au point d'un principe variationnel pour les equilibres entre rayonnement, reaction et conduction permet la determination des conditions critiques d'auto-allumage de corps convexes. Enfin, on considere la propagation des flammes en milieu gazeux premelange et ensemence par des particules solides inertes. Pour de telles flammes spheriques, une dynamique de relaxation tres riche est mise en evidence aussi bien en espace libre (configuration d'une explosion accidentelle) qu'en volume clos (configuration experimentale). Il est aussi montre que le rayonnement peut modifier les instabilites hydrodynamiques (type landau-darrieus) des fronts faiblement plisses. Puis, une description plus unifiee des regimes et limites de propagation est mise en place, prenant en compte prechauffage radiatif, effets d'extinction cinetique et conduction. Il y est suggere que les flammes de poussieres reactives pourraient etre simulees par celles de premelanges gazeux de faible reactivite et ensemences. Enfin, une etude de stabilite lineaire indique l'existence d'une bifurcation de hopf pour des nombres de zel'dovich suffisamment eleves. Ces comportements ont pour origines le caractere non local du transfert thermique radiatif, son intensite et sa longueur de reference qui est grande devant la portee des processus moleculaires. Si la forte non linearite de la loi d'arrhenius est preponderante, celle de la loi de stefan n'y joue aucun role qualitatif
STRATEGI PENGEMBANGAN PRODUK UNGGULAN DAERAH MELALUI KEBIJAKAN PEMERINTAH DAERAH KABUPATEN BONDOWOSO

This research resulted in the superior product development strategy of Bondowoso Regency that is tape. By analyzing tape problems from upstream to downstream, the results of the analysis resulted in policy recommendations for the development of superior products of Tape Bondowoso. The research approach used is Qualitative with Descriptive Method by explaining the context and setting naturally. The results of this study provide an overview, first, Decrease in Cassava Production caused cassava farmers to switch to other commodities such as coffee or corn. Second, the pattern of cassava farming is still traditional. Third, the lack of skills (life skills) owned by cassava farmers. Fourthly, the instability of cassava prices caused cassava farmers to suffer losses. Fifth, Difficulty Accessing Capital and the market.
Towards Ultrastrong Glasses

The development of new glassy materials is key for addressing major global challenges in energy, medicine, and advanced communications systems. For example, thin, flexible, and large‐area glass substrates will play an enabling role in the development of flexible displays, roll‐to‐roll processing of solar cells, next‐generation touch‐screen devices, and encapsulation of organic semiconductors. The main drawback of glass and its limitation for these applications is its brittle fracture behavior, especially in the presence of surface flaws, which can significantly reduce the practical strength of a glass product. Hence, the design of new ultrastrong glassy materials and strengthening techniques is of crucial importance. The main issues regarding glass strength are discussed, with an emphasis on the underlying microscopic mechanisms that are responsible for mechanical properties. The relationship among elastic properties and fracture behavior is also addressed, focusing on both oxide and metallic glasses. From a theoretical perspective, atomistic modeling of mechanical properties of glassy materials is considered. The topological origin of these properties is also discussed, including its relation to structural and chemical heterogeneities. Finally, comments are given on several toughening strategies for increasing the damage resistance of glass products.
Comparison of formaldehyde emission from building finishing materials at various temperatures in under heating system; ONDOL.

UNLABELLED The objective of this research was to investigate the effect of various temperatures, room, 37 and 50 degrees C, on formaldehyde emission from floor materials, such as laminate and plywood floorings, and furniture materials, such as MDF and particleboard veneered with decorative paper foil, by desiccator's method. The temperature conditions were set up by, measuring the temperature in a Korean under heating system. To maintain an indoor air temperature of 20 degrees C, the temperature of the flooring surface was about 37 degrees C and the temperature of the cement mortar was 50 degrees C. The initial formaldehyde emission of the laminate flooring and plywood flooring was 1.44 and 0.63 mg/l, and for MDF and particleboard it was 4.73 and 4.95 mg/l, respectively. Floor materials were under E1 grade while furniture materials were under E2 grade in terms of formaldehyde emission. Because of the under heating system, the flooring materials were exposed to 37 and 50 degrees C, while the furniture materials mostly existed at room temperature. At 37 and 50 degrees C, the formaldehyde emission level of the flooring materials was already under 0.3 ppm (F level by JIS A 1460, application possibility without area limit) after 10 days and the emission had decreased further (0.03-0.10 mg/l) after 28 days. These levels are not injurious to the human body and will not cause sick house syndrome (SHS). The problem, however, is the furniture materials such as MDF and particleboard. As these materials are not exposed to high temperature (50 degrees C in this experiment) in living condition, it was still E2 grade of formaldehyde emission level at room temperature remained even after 28 days. Although there will be variations with the volume of furniture materials and the indoor conditions, furniture materials are the principal cause of indoor air quality pollution in Korean with the under heating system. PRACTICAL IMPLICATIONS Koreans spend most of their time sitting on ONDOL (heated) floors, with their buttocks always in contact with the floor surface. The flooring materials are exposed to high temperatures (37-50 degrees C) why the effect of bake-out is rapid. The emission of formaldehyde from furniture materials are more important for the IAQ because usually MDF and particleboard of E2 grade are being used as furniture materials in Korea.
Periodic fast radio bursts from forcedly precessing neutron stars, anomalous torque, and internal magnetic field for FRB 180916.J0158+65 and FRB 121102

A recent discovery of the periodic activity of the repeating fast radio burst source FRB 180916.J0158+65 in the Canadian Hydrogen Intensity Mapping Experiment (CHIME) hints at possible origin of the FRB from a freely precessing neutron star with a magnetar magnetic field of about $10^{16}$ G. However, the absence of simultaneously detected high-energy emission in the Swift and AGILE observations imposes stringent constraints on the field magnitude and questions the possibility of such a progenitor. We show that consideration of forced precession of a neutron star does not encounter the difficulty. This kind of precession takes place even if the neutron star is not deformed and is brought about by the anomalous moment of electromagnetic forces induced by stellar rotation and determined by non-corotational currents. Contrary to what is expected for the currents of corotation, the anomalous torque calculated by the direct method appears to be non-zero. If the observed 16.35-day period corresponds to the period of stellar precession, the inferred internal magnetic field appears to be about $6\times10^{14}$ G for rotational period 1 s. For another possibly periodic FRB 121102 with 157-day period the magnetic field is even lower, $2\times10^{14}$ G, thereby justifying earlier considerations and not ruling out the hypothesis of FRB origin from precessing neutron stars.
Dependence of hepatocyte‐specific gene expression on cell‐cell interactions in primary culture.

In co‐culture with non‐parenchymal liver epithelial cells, rat hepatocytes show a marked increase in albumin and total protein synthesis when compared with cells maintained as pure populations in which an early decline in albumin secretion takes place. Analysis of the relative amounts of different mRNA sequences, determined by hybridization, indicated that the increase in protein synthesis resulted essentially from an increased level of the corresponding mRNAs. In addition, when cell‐cell contacts were established between the two cell types several days after the seeding of hepatocytes, the stimulation of albumin secretion was similarly observed with a significant increase of the corresponding mRNA on days 10‐14 of culture. Transcriptional assays, in which isolated nuclei were used for the study of RNA synthesis, showed that liver‐specific gene transcription was significantly increased and maintained for at least 2 weeks. These results demonstrate for the first time long‐term stabilization and reversibility of various specific mRNAs at high levels by adult hepatocytes in primary culture. They suggest that establishment of cell‐cell contacts between hepatocytes and liver epithelial cells are essential for the maintenance of a high rate of transcription of the liver‐specific genes.
1H-NMR studies of calmodulin. The nature of the Ca2+-dependent conformational change.

Using assignments of resonances in the 1H-NMR spectrum of calmodulin obtained by the use of large tryptic fragments of the molecule [Dalgarno, D. C. , Klevit, R. E. , Levine, B. A. , Williams, R. J. P., Dobrowolski, Z. , and Drabikowski, W. (1984) Eur. J. Biochem. 138, 281--289], the spectral changes which occur on Ca2+ binding to calmodulin have been examined in detail. Ca2+ binding occurs in two stages: the first two Ca2+ ions bind at sites III and IV (numbered from the N terminus) and the second two Ca2+ ions bind at sites I and II. The high-affinity binding causes perturbations of residues in both halves of the molecule, whereas binding at the two N-terminal sites only affects sidechains in that half of the molecule. The effects of binding Cd2+ to the Ca2+-binding sites of calmodulin have also been studied by 1H NMR. The cation induces spectral changes which are very similar to those seen for Ca2+, but some important differences do exist.
Hypothalamic regulation of growth hormone secretion.

To investigate neural control of growth hormone (GH) secretion, the effect of hypothalamic lesions on resting GH plasma concentrations and GH response to insulininduced hypoglycemia was studied in squirrel monkeys. Plasma GH was determined by radioimmunoassay using a human growth hormone system. In 9 control animals with small lesions in the frontal cortex, hypoglycemia induced by the intravenous injection of insulin, 0.15 U/kg body wt, led to an acute rise in GH. Of 16 animals with lesions in various basilar brain structures, 8 had either markedly reduced or completely blocked GH responses to hypoglycemia. Anatomical analysis of the site of the lesions suggests that the anterior median eminence, central median eminence and pituitary stalk mediate reflex GH discharge. Resting levels of GH were not altered by hypothalamic lesions, a finding which is indicative of a reasonable degree of autonomy of basal GH secretion. During the first hr of the insulin tolerance test, blood sugar changes had a similar time .
Relationship Between Technology Leadership, ICT Facility, Competency, Commitments Towards Effectiveness of School Mangement Tasks in Schools

Previous studies more engaged to the level of technology leadership and the characteristics of technological leadership practiced by leaders in the school, while the factors of a more comprehensive which include facilities for ICT, competence, and commitment of teachers in the practices of applying ICT in the management which contributes a great impact on the management duties of teachers in schools has not been studied in Malaysia. The purpose of this study is to identify whether there is a positive relationship between technology leadership, ICT facilities, competence, commitment and practice of applying ICT teachers with effective management duties of teachers in schools using ICT. This quantitative study involves 370 teachers in secondary schools in the Kedah state which were selected randomly. The findings from the analysis of the study using the smartPLS show that there is a significant relationship between the leadership of technology by principals in school and the effectiveness of teacher-management tasks using computers in management tasks. Leadership that practices high technology leadership features will have a positive impact on the effectiveness of ICT integration within the organization. Further study can be conducted with integrating UTAUT model to identify critical factors that contributing technology leadership in schools.
CBMM Memo No . 056 October 24 , 2016 Where do hypotheses come from ?

Why are human inferences sometimes remarkably close to the Bayesian ideal and other times systematically biased? One notable instance of this discrepancy is that tasks where the candidate hypotheses are explicitly available result in close to rational inference over the hypothesis space, whereas tasks requiring the self-generation of hypotheses produce systematic deviations from rational inference. We propose that these deviations arise from algorithmic processes approximating Bayes' rule. Specifically in our account, hypotheses are generated stochastically from a sampling process, such that the sampled hypotheses form a Monte Carlo approximation of the posterior. While this approximation will converge to the true posterior in the limit of infinite samples, we take a small number of samples as we expect that the number of samples humans take is limited by time pressure and cognitive resource constraints. We show that this model recreates several well-documented experimental findings such as anchoring and adjustment, subadditivity, superadditivity, the crowd within as well as the self-generation effect, the weak evidence, and the dud alternative effects. Additionally, we confirm the model's prediction that superadditivity and subadditivity can be induced within the same paradigm by manipulating the unpacking and typicality of hypotheses, in 2 experiments. This work was supported by the Center for Brains, Minds and Machines (CBMM), funded by NSF STC award CCF-1231216. Where do hypotheses come from? Ishita Dasgupta Department of Physics and Center for Brain Science Harvard University Eric Schulz Department of Experimental Psychology University College London Samuel J. Gershman Department of Psychology and Center for Brain Science Harvard University
Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca2+ Leak in Chronic Heart Failure

Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor in the pathogenesis of heart failure (HF). However, the specific molecular causes underlying RyR2 defects in HF remain poorly understood. In the present study, we used a canine model of chronic HF to test the hypothesis that the HF-related alterations in RyR2 function are caused by posttranslational modification by reactive oxygen species generated in the failing heart. Experimental approaches included imaging of cytosolic ([Ca2+]c) and sarcoplasmic reticulum (SR) luminal Ca2+ ([Ca2+]SR) in isolated intact and permeabilized ventricular myocytes and single RyR2 channel recording using the planar lipid bilayer technique. The ratio of reduced to oxidized glutathione, as well as the level of free thiols on RyR2 decreased markedly in failing versus control hearts consistent with increased oxidative stress in HF. RyR2-mediated SR Ca2+ leak was significantly enhanced in permeabilized myocytes, resulting in reduced [Ca2+]SR in HF compared to control cells. Both SR Ca2+ leak and [Ca2+]SR were partially normalized by treating HF myocytes with reducing agents. Conversely, oxidizing agents accelerated SR Ca2+ leak and decreased [Ca2+]SR in cells from normal hearts. Moreover, exposure to antioxidants significantly improved intracellular Ca2+-handling parameters in intact HF myocytes. Single RyR2 channel activity was significantly higher in HF versus control because of increased sensitivity to activation by luminal Ca2+ and was partially normalized by reducing agents through restoring luminal Ca2+ sensitivity oxidation of control RyR2s enhanced their luminal Ca2+ sensitivity, thus reproducing the HF phenotype. These findings suggest that redox modification contributes to abnormal function of RyR2s in HF, presenting a potential therapeutic target for treating HF.
ARC: A Synchronous Stream Cipher from Hash Functions

We consider a simple and secure way to realize a synchronous stream cipher from iterated hash functions. It is similar to the OFB mode where the underlying block cipher algorithm is replaced with the keyed hash function, adopting the secret su(cid:30)x method[20]. We analyzed the key, the keystream and the necessary properties to assume from the underlying hash function for the stream cipher to be considered secure. Motivated by our analysis we conjecture that the most e(cid:30)cient way to break the proposed stream cipher is to break the hash function or through exhaustive search for the keyspace K of k bits, that requires O (2 k ) operations.
Imprecise Imputation as a Tool for Solving Classification Problems with Mean Values of Unobserved Features

A method for solving a classification problem when there is only partial information about some features is proposed. This partial information comprises the mean values of features for every class and the bounds of the features. In order to maximally exploit the available information, a set of probability distributions is constructed such that two distributions are selected from the set which define the minimax and minimin strategies. Random values of features are generated in accordance with the selected distributions by using the Monte Carlo technique. As a result, the classification problem is reduced to the standard model which is solved by means of the support vector machine. Numerical examples illustrate the proposed method.
Production and genetic improvement of novel antimycotic agent, saadamycin, against dermatophytes and other clinical fungi from endophytic Streptomyces sp. Hedaya48

As a part of our ongoing efforts towards finding novel antimycotic and other bioactive agents from marine microflora of the Red Sea, recently secondary metabolites secreted by endophytes of some marine corals or sponges in Egypt were investigated. The new bioactive endophytic Streptomyces sp. Hedaya48 was isolated from the Egyptian sponge Aplysina fistularis and identified, which exhibited strong antimycotic activity against dermatophytes and other clinical fungi. Saadamycin [4-(hydroxymethyl)-5- hydroxy-2H-pyran-2-one] a newantimycotic compound, 5,7-dimethoxy-4- iÂ²-methoxylphenylcoumarin and vanillin were isolated from Streptomyces sp. Hedaya48. The producing strain was subjected to different UV irradiation doses and a mutant strain Ah22 with 10.5-fold higher saadamycin production was isolated (420mg/l as compared to 40mg/l produced by the parental strain). Production of saadamycin frommutantAh22was enhanced to 2.26 -fold (950mg/l) under optimized culture condition in batch culture and 2.38-fold increasing (1000mg/l) in bioreactor more than the yield obtained with the mutant strain Ah22 in normal production medium. Both saadamycin and 5,7-dimethoxy-4-iÂ²-methoxylphenylcoumarinwere exhibited significant antifungal activities against several dermatophytes and other clinical fungal isolates as Aspergillus fumigatus and Candida albicans.
Let the credits Roll: a Preliminary Examination of the Role played by Mentors and Trusted Assessors in disciplinary Formation

Many scholarly articles acknowledge input from colleagues, mentors and trusted assessors. This study explores the social function and cognitive significance of acknowledgements. A six category typology was developed and applied to 444 acknowledgements which were carried by research articles in JASIS (1970–1990). It is proposed that acknowledgements and citations should be used conjointly in the assessment of research performance and in disciplinary exegesis.
Phosphorus Release Characteristics from Biosolids-Derived Organomineral Fertilizers

This study investigated the availability of phosphorus (P) following soil application of a novel biosolids-derived organomineral fertilizer (OMF15; 15:4:4) in comparison with single superphosphate (0:18:0). Two soil types of contrasting characteristics were incubated over a period of 90 days at 25 °C and maintained near field capacity. Phosphorus was applied at rates equivalent to 0 (control), 150, and 300 kg ha−1 of P2O5, respectively. Availability of P from OMF15 was low throughout the experiment accounting for less than 6.5% of total OMF15-P applied. It was shown that after the 90 days incubation period, the overall increase in soil extractable P in OMF15-treated soil was marginal in both soil types. For single superphosphate (SSP), P availability ranged from 16% to 46% of total SSP-P applied. Application of SSP increased soil extractable P levels significantly (P < 0.001) compared with unfertilized control soils. The results of this study aided the development of fertilization strategies for the best use of OMF produced from nutrient-enriched biosolids granules for applications in winter cereal and grass crops in England.