Miracle-dz/UniFAR-FTUs huggingface dataset:
Períodos críticos de plasticidad cortical

Introduccion y desarrollo. Las alteraciones de la experiencia sensorial causan reordenamientos a gran escala de la conectividad cortical solo en etapas tempranas de la vida. Tras un periodo critico que aproximadamente termina en la pubertad, modificaciones similares requieren manipulaciones mas invasivas, entre ellas deaferentacion y lesiones corticales. En el ambito celular, los mecanismos elementales responsables de la modificacion sinaptica parecen estar disponibles a lo largo de toda la vida. Por consiguiente, en adultos, la plasticidad dependiente de la experiencia podria estar limitada a factores adicionales, como la maduracion de la inhibicion o cambios en la matriz extracelular. Esta vision es compatible con una capacidad de modificacion limitada, pero no ausente, de los circuitos corticales adultos. Esta idea tambien tiene interesantes implicaciones terapeuticas. Conclusion. En este escenario, la manipulacion de estos factores limitantes, como la reduccion de la inhibicion sinaptica, podria ser una estrategia util para incrementar la plasticidad en la corteza adulta
ON SOME NEW Pδ-TRANSFORMS OF KUMMER'S CONFLUENT HYPERGEOMETRIC FUNCTIONS

The aim of our paper is to present Pδ -transforms of the Kummer’s conﬂuent hypergeometric functions by employing the generalized Gauss’s second summation the-orem, Bailey’s summation theorem and Kummer’s summation theorem obtained earlier by Lavoie, Grondin and Rathie [9]. Relevant connections of certain special cases of the main results presented here are also pointed out.
Effects of daily ingestion of chilli on serum oxidation in adult men and women

Background - Laboratory studies have shown that the resistance of isolated low density lipoprotein (LDL) cholesterol or linoleic acid to oxidation is increased in incubations with chilli extracts or capsaicin - the active ingredient of chilli. It is unknown if these in vitro antioxidative effects also occur in serum of people eating chilli regularly. Objective: To investigate the effect of daily ingestion of chilli on serum oxidation in adult men and women Design - This study investigated the effects of regular consumption of chilli on in vitro serum lipoprotein oxidation and total antioxidant status, in healthy adult men and women. In a randomized cross over study, twenty seven participants (13 men and 14 women) ate 30g/day of Freshly chopped chilli-blend (55% cayenne chilli) and no chilli (bland) diets, for four weeks each. Use of other spices such as cinnamon, ginger, garlic, mustard was restricted to minimum amounts. At the end of each dietary period serum samples were analysed for lipids, lipoproteins, total antioxidant status (TAS) and copper-induced lipoprotein oxidation. Lag time (before initiation of oxidation), and rate of oxidation (slope of propagation phase) were calculated. Outcomes - There was no difference in the serum lipids, lipoproteins and TAS at the end of the two dietary periods. In the whole group, the rate of oxidation was significantly lower (mean difference MD -0.23 A*10-3/min; p = 0.04) after the chilli diet, compared to the bland diet. In women, lag time was higher (MD 9.61min; p < 0.001) after the chilli diet, compared to the bland diet. Conclusions -Regular consumption of chilli for four weeks increases the resistance of serum lipoproteins to oxidation.
PENGARUH KEADILAN ORGANISASI TERHADAP KOMITMEN AFEKTIF DALAM KALANGAN KAKITANGAN HOTEL DI MELAKA: MODAL PSIKOLOGI SEBAGAI PENGANTARA

Kajian ini mengkaji kesan pengantara modal psikologi dalam mempengaruhi antara keadilan pengedaran, keadilan prosedur, keadilan interaksi dan komitmen afektif. Masih terdapat kekurangan penyelidikan yang meneliti peranan modal psikologi sebagai pengantara dalam rangka kajian sebelumnya kerana ianya masih merupakan konsep baru terutamanya dalam kalangan setiap kakitangan hotel di Melaka. Sejumlah 209 responden dari kumpulan pengurusan tertinggi, pengurusan dan profesional dan kumpulan sokongan dari tujuh buah hotel di Melaka, Malaysia yang mengambil bahagian dalam kajian ini. Data dianalisis menggunakan prosedur Pemodelan Persamaan Struktur untuk menilai hubungan langsung dan tidak langsung dalam kalangan pembolehubah. AMOS versi 21.0 digunakan untuk melakukan analisis regresi. Tiga model telah diuji untuk menentukan sama ada model hipotesis sesuai dengan data. Penemuan kajian ini mendapati bahawa keadilan pengedaran, keadilan interaksi secara signifikan mempengaruhi komitmen afektif, namun keadilan prosedur tidak mempengaruhi komitmen afektif. Keputusan juga menunjukkan bahawa modal psikologi sebagai pengantara separa dalam hubungan antara dua dimensi keadilan organisasi iaitu keadilan pengedaran dan keadilan interaksi terhadap komitmen afektif, namun modal psikologi menjadi pengantara penuh dalam keadilan prosedur terhadap komitmen afektif. Kesimpulannya, jangkaan kajian ini menunjukkan bahawa modal psikologi memainkan peranan penting dalam menyumbang kepada literatur keadilan organisasi dan juga dalam meningkatkan komitmen afektif setiap kakitangan di hotel. Kata Kunci: Pemodelan Persamaan Struktur, AMOS versi 21.0, keadilan pengedaran, keadilan prosedur, keadilan interaksi, modal psikologi, komitmen afektif, pengantara, analisis regresi, kakitangan hotel.
Stabilizing Effect of High Pore Fluid Pressure on Slip Behaviors of Gouge‐bearing Faults

We conducted experiments to investigate the influence of pore fluid pressure on the frictional strength and slip behavior of gouge bearing faults. Saw cut porous sandstone samples with a layer of gouge powders placed between the precut surfaces were deformed in the conventional triaxial loading configuration. A series of velocity‐step tests were performed to measure the response of the friction coefficient to variations in sliding velocity. Pore volume changes were monitored during shearing of the gouge. Our results demonstrate that under constant effective pressure, increasing pore pressure stabilizes the frictional slip of faults with all four gouge materials including antigorite, olivine, quartz, and chrysotile. The stabilizing effect is the strongest in antigorite gouge, which shows an evolution of friction parameters from velocity‐weakening toward velocity‐strengthening behavior with increasing pore pressure. Experiments with controlled pore volume show that the pore volume reduction diminishes under high pore fluid pressures, implying an increasing dilation component at these conditions. The dilatant hardening mechanism can explain the observed strengthening. These results provide a possible explanation to the observed spatial correlation between slow slip events and high pore pressure in many subduction zones.
Regresyon ve Kriging Meta-Modelleri için Kullanılan Deney Tasarımı Yöntemleri

Benzetim modelinden veri uretmenin oldukca zaman alici oldugu durumlarda eniyileme, duyarlilik analizi gibi amaclarla meta-model kullanilir. Deney tasarimi meta-model kurma calismalarinin en onemli asamalarindan biridir ve benzetim modelinin hangi girdi degiskenleri kombinasyonlari icin calistirilacagi belirlenir. Secilen meta-modelin yapisina uygun deney tasarimi kullanilmasi gerekir. Bu calismada literaturde regresyon ve kriging meta-modelleri icin kullanilan deney tasarimi yontemleri incelenmis ve yorumlanmistir.
Nasal tip plasty using three-dimensional printed polycaprolactone (Smart Ball®)

Background Rhinoplasty is one of the most commonly performed cosmetic surgery procedures. Most Asians desire elevation of their relatively flat nasal dorsum and tip to make them appear more prominent. This study introduces a simple method of nasal tip plasty using three-dimensional (3D)-printed polycaprolactone (PCL) (Smart Ball®), which provides the required length and volume for this purpose and enables the creation of a nasal tip of the desired shape in a safe and simple manner. Methods Between September 2014 and May 2017, 22 patients participated in a survey to assess postoperative satisfaction levels. Additionally, three plastic surgeons compared patients’ pre- and 1-year postoperative photographs to evaluate the results. All patients underwent 2- to 4-year postoperative follow-up. Results Levels of subjective satisfaction among patients were 3.59, 3.50, 3.82, 3.73, 3.55, and 3.82 for each of the 6 categories evaluated, with a mean of 3.67/4 points, indicating high satisfaction levels. The mean plastic surgeon-reported score for the 22 patients was 4.47/5 points, which also indicates highly successful outcomes. Postoperative nasal tip rotation and tip projection were ideal in most patients. Conclusion Our novel method using 3D-printed PCL (Smart Ball®) provides the optimal length and volume required for nasal tip plasty and enables the creation of a nasal tip of the desired shape, in a safe and simple manner. An advantage of our method is that it retains the original nasal structure in contrast to structural changes observed with the use of conventional methods.
Papel citoprotetor da indução da heme oxigenase-1 na lesão renal progressiva Cytoprotective role of heme oxygenase-1 upregulation in progressive renal disease

objective: This study evaluated the ability of heme oxygenase-1 to prevent or reverse renal fibrosis. Methods: Sprague-dawley male rats were submitted to unilateral ureteral obstruction and divided into groups: non-treated and hemin. Biochemical and histological analyses were performed. We also conducted RT-PCR to verify the expression of heme oxygenase-1, MCP-1, IL1-β, IL-6, TNF-α, COL-I, COL-III, PAI-1 and fibronectin mRNA. results: heme oxygenase-1 expression significantly increased in treated animals. The non treated group showed significantly higher levels of proteinuria than the Hemin group. The protein/urinary creatinine ratio in obstructed pelvis was also higher in non treated group, which also showed greater albuminuria and higher percentage of fibrosis when compared to the Hemin group. The expression of pro-inflammatory and pro-fibrotic molecules was significantly higher in the non treated group. Conclusions: The treatment induced the expression of heme oxygenase-1, preventing the installation of fibrosis and even limiting its progression.
Surgical procedures performed to improve the prosthetic prognosis in case of maxillary defects: a review of the literature

Aim The purpose of this review is to address the surgical procedures that need to be followed to obtain a maxillary defect that can be suitable to receive a prosthesis. Methods An extensive search of the literature was performed, on the databases of PubMed/Medline and Scopus, in addition to congress proceedings and books, written in English or Italian. Literature search was performed using combinations of the following keywords: (“obturator prognosis” OR “palatal obturator” OR “obturator prosthesis” OR “prosthetic prognosis”) AND (“maxillectomy” OR “maxillary defect”). Results 35 articles, 2 books and 3 congress proceedings were included. After the study of the records included in this review, it was found that surgeon must preserve the anterior maxilla as much as possible, because it is the most suitable site for the placement of implants. Furthermore, if the implant site is involved in post-operative radiotherapy, it is advisable to know the x-ray dose of such an exposition. The surgical cut should preserve mucosa and bone support around the tooth adjacent to the defect, and keratinized mucosa should cover the palatal margin of the defect Equally important is to prepare an adequate access to the defect, because the turbinates and the bands of oral mucosa may prevent the prosthesis from engaging key areas of the defect, impairing function. Conclusion A complete knowledge about the construction techniques and biological/mechanical principles of maxillofacial prosthesis is essential to perform surgical interventions that enhance the prosthetic prognosis.
Factors for predicting and the quality of sleep as perceived by nurses in southern regional hospitals and medical centers

The purposes of this research were to study sleep quality and the predictors of sleep quality as perceived by nurses working at the southern regional hospital and medical centers. Two hundred and forty nurses were selected by random sampling. The research parameters were personal factors, fatigue and the quality of sleep. Fatigue and Sleep Quality scales were tested for the content validity by five experts. The reliability with Cronbach's alpha coefficient of Fatigue and Sleep Quality Scales were 0.92 and 0.72, respectively. The data were analyzed by percentage, mean, standard deviation, Pearson's product moment correlation coefficient, and stepwise multiple regression analysis. The major findings were as follows: 1. Nurses had good levels of sleep quality (X=110, SD=16.74, total scores = 150). 2. Fatigue had a significant negative relationship to sleep quality (r=-.521), while doing exercise had a significant positive relationship to quality of sleep (r=.204). 3. Variables significantly predicting the sleep quality of nurses, at p=. 05, were fatigue and doing exercise. These predictors accounted for 28.7% of the variance. These results indicated that fatigue was a factor decreasing sleep quality but doing exercise was a factor improving sleep quality of nurses in the southern regional hospital and medical centers.
Is critical care service relevant to Iran's hospital care?

The numbers of acutely ill patients (AIP) are admitted in general hospital wards increased. The failing to identify, manage and deliver timely and optimal care to AIPs may lead to catastrophic outcomes. A qualitative study aimed to define the current state of AIPs in Iranian hospitals showed the flaws and shortcomings in the current services for identifying and managing AIPs. An evaluation study was designed to explore the potential impact of Critical Care Service (CCS) in an Iranian University Hospital. The study design was a Stepped-Wedge Cluster Randomized Controlled Trial. The study included, for each ward, an unexposed to the intervention, training, and an exposed to the intervention phase. The data was analyzed using three methods: all patients, matched randomized and before-after. The null-hypothesis was tested using the mixed effect logistic regression, linear mixed and the mixed effects models. The results showed that there are no significant differences in mortality, CPR, ICU admission and length of stay. A second qualitative to find the views of staffs toward the CCS indicated that the CCS had several favorable effects, however; overcoming contextual problems in the hospital, prior to implementation of CCS, may facilitate its implementation.
Vigencia conceptual de los factores de la motivación: una perspectiva desde la teoría bifactorial propuesta por Hezberg.

is paper aims to analyze the conceptual validity of motivational factors based on the bifactorial theory proposed by Herzberg and R. (1963); for which, an approach is made to the factors and perspectives that prevail today. e qualitative approach was used as a methodology Taking into account the literature review systematized from the Scopus database and the SJR Scimago Journal Rank. In the same way, the analysis of the results is observed Regarding the current research and the motivational factors based on a characterization of the articles. n this way the state of the factors in the last years was evidenced and it was found that this behavioral model is current and influences the organizational development.
Dehydration of the Elderly in Nursing Homes

Author(s): Garcia, Marcela Esperanza | Abstract: Research findings show that the elderly in nursing homes are receiving inadequate amounts of fluid intake to sustain health and prevent dehydration. Research reveals that a great percentage of the nursing home residents are not receiving the minimum fluid intake requirement of 1,500 mL/day. Given that this population is predisposed to dehydration as a result of aging, inadequate fluid intake places the elderly at greater risk for dehydration and even death. Examining dehydration in the elderly not only forces investigators to examine the health of the nursing home population, but also the quality of care that is received.
Joslin's Diabetes Deskbook: A Guide for Primary Care Providers

Chapter 1 Diabetes: Definition Pathophysiology Introduction Normal Glucose Homeostasis The Pancreas Insulin Production The Pathophysiology of Diabetes Types of Diabetes Epidemilogy of Diabetes Chapter 2 The Approach to Diagnose and Treatment of Diabetes Mellitus Diagnosing Diabetes Symptoms of Diabetes Standards of Care Treating Diabetes Aggressively Chapter 3 Monitoring Diabetes The Importance of Self-Monitoring of Blood Glucose and Glycohemoglobin Measurements Chapter 4 Adipose tissue as an Endocrine Gland: A Possible Key in Understanding the Metabolic Mysteries Understanding the Endocrine Role of Adipose Tissue Chapter 5 Medical Nutrition Therapy and Diabetes Nutrition Therapy Is Not New Chapter 6 Physical Activity for Fitness Effect of Physical Activity on People without Diabetes Chapter 7 Type 2 Diabetes: Multiple Treatments for a Multicomponent Condition Insulin Resistance Chapter 8 Pharmacotherapy for Type 2 Diabetes: Medications to Match the Pathophysiology Options for Therapy The Classes of Antidiabetes Medicatioins Chapter 9 Using Insulin To Treat Diabetes-General Principles Endogenous Insulin Insulin for Exogenous Therapy Chapter 10 Designing a Conventional Insulin Treatment Program Indications for Inslin Therapy Goals of Insulin Treatment Chapter 11 Physiologic Insulin Treatment Programs What Is Physiologic Insulin Therapy Why Physiologic therapy Makes Sense Chapter 12 Educating the Patient The Emotional Component Evaluation, Negotiation and Goal Setting Chapter 13 Acute Complications Diabetic Ketoacidosis(DKA) Hyperosmolar Hyperglycemic State (HHS) Chapter 15 Macrovascular Complications Hypertension Dyslipidemia Chapter 16 Diabetic Neuopathy Classification Evaluation of Diabetic Peripheral Neuropathy Chapter 17 The Foot: Clinical Care and Problem Prevention Risk Factors for Foot Wounds The Foot Examination Chapter 18 Surgical Management of the Patient with Diabetes General Approach to Surgical Management Preoperative Evaluation Chapter 19 Gender-Specific Issues Women's Health Issues Male Sexual Dysfunction Chapter 20 Pregnancy and Diabetes Metabolic Changes during Pregnancy Gestational Diabetes(GDM) Pregestational Diabetes - Preparing Women with Type 1 or Type 2 Diabetes for Pregnancy Chapter 21 Treatmenr of Children with Diabetes Epidemilogy Team Approach to Patient Care Goals of Treatment Chapter 22 Diabetes in the Older Adult Treatment Goals Screening for and Diagnosing Diabetes Chapter 23 Psychological Issues in the Treatment of Diabetes Diagnosis and Ongoing Support Major Psychological Obstacles to Diabetes Care Chapter 24 Diabetes in Culturally Diverse Populatiions: Facing the Challenge in Clinical Practice Type 2 Diabetes in Culturally Diverse Populations:Genes or Culture? Biological Factors
Caracterização do insumo ibuprofeno e a correlação com propriedades de dissolução e de fluxo

O ibuprofeno e um agente anti-inflamatorio nao esteroide, derivado do acido fenilpropionico que possui atividade anti-inflamatoria de acao moderada. Sua acao analgesica esta relacionada as propriedades anti-inflamatorias devido a reducao da producao da ciclooxigenase-1 (COX-1) e da ciclooxigenase-2 (COX-2). O ibuprofeno exibe diferentes morfologias quando cristalizado em diferentes solventes. Neste estudo, se avaliaram as caracteristicas de materias-primas do ibuprofeno e o impacto destas nas propriedades de dissolucao e processamento. Foram avaliadas tres materias-primas do ibuprofeno de tres diferentes fabricantes, utilizando variadas tecnicas de caracterizacao. As analises confirmaram que todas apresentavam a mesma forma cristalina do ibuprofeno; assim, o polimorfismo foi descartado como uma das causas de influencia na dissolucao e no fluxo do farmaco. Os resultados mostraram que caracteristicas fisicas da materia-prima ibuprofeno tiveram impacto nas propriedades de fluxo e dissolucao e que existe uma variabilidade das caracteristicas fisicas do farmaco entre diferentes fabricantes. Isto mostra a importância da avaliacao de caracteristicas da materia-prima para correlaciona-las com propriedades de desempenho, possibilitando o desenvolvimento e melhoramento farmacotecnico. Palavras-chave: Ibuprofeno. Molhabilidade. Fluxo. ABSTRACT Characterization of ibuprofen raw material and correlation with dissolution and flow properties Ibuprofen is a moderately active non-steroidal antiinflammatory drug, derived from β-phenylpropionic acid. Its analgesic action, which is related to its antiinflammatory properties, is due to a decrease in the production of enzymes cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2). Ibuprofen exhibits distinct morphologies when crystallized under different conditions. In this study, the characteristics of the ibuprofen raw material and their impact on drug dissolution and processing properties were analyzed. Samples of raw ibuprofen from 3 different manufacturers were characterized by a variety of techniques. The analysis confirmed that all 3 samples exhibited the same crystalline form; thus, polymorphism could be discarded as one of the causes of any variation in performance of the drug. The results showed that the physical characteristics of each sample influenced its flow and dissolution properties. In fact, there was a detectable variation in the physical characteristics of the drug among the 3 different manufacturers. This demonstrates the importance of testing the characteristics of the drug raw material in order to correlate them with its performance in processing and eventual use, enabling pharmacotechnical improvement and development. Key words: Ibuprofen. Wettability. Flow.
Manipulateurs paralleles, 4eme partie : mode d'assemblage et cinematique directe sous forme polynomiale

Dans cette quatrieme partie, nous allons nous interesser aux developpements recents du probleme de la cinematique directe, exprimee sous forme polynomiale- , ainsi qu'a son corollaire qui est a l'etude des modes d'assemblages, a variables articulaires fixees, des robots paralleles. Dans une premiere partie, on considere les manipulateurs paralleles plans. On y montre que la cinematique directe peut toujours s'exprimer sous la forme d'un polynome mono-variable. Pour les robots planaires classiques un majorant du degre de ce polynome est 6. Une resolution numerique permet de montrer que l'on peut effectivement definir un manipulateur possedant 6 modes d'assemblage. On considere ensuite le cas d'un manipulateur spatial, a 6 degres de liberte, ou la plate-forme mobile est triangulaire et des longueurs de segments variables (type TSSM). On montre alors geometriquement qu'il y a au plus 16 manieres de monter le manipulateur, puis que le probleme de la cinematique directe peut se ramener effectivement a la resolution d'un polynome de degre 16, dont on donne la formulation analytique. On presente un exemple ou le nombre de montage maximum est atteint. On etudie le meme probleme pour deux architectures nouvelles developpees au sein du projet Prisme ainsi que pour la fameuse plate-forme de Stewart. On considere ensuite les diverses architectures de robot parallele proposees dans la litterature pour lesquelles l'on etablit dans chaque cas un majorant du nombre de montage possible et l'on donne le degre du polynome qui a pu etre trouve. Des resultats precedents ont deduit l'impossibilite de resoudre analytiquement le probleme de la cinematique directe.