Miracle-dz/UniFAR-FTUs huggingface dataset:
Postoperative Cognitive Dysfunction: Preclinical Highlights and Perspectives on Preventive Strategies

One of the common complications associated with anaesthesia and surgery in geriatric patients is the postoperative cognitive dysfunction (POCD). This cognitive impairment affects the long-term prognosis and has been shown to be associated with long-term disability, higher health care costs, and even increased mortality. On the other hand, clinical research on POCD is in its infancy, the condition has not been clarified, and since no strategy for management is currently available, it is imperative to develop specific methods for prevention and management. Although its pathogenesis involves various factors, accumulating evidence suggests that surgery elicits an inflammatory response in the hippocampus, a brain area closely related to cognitive function, playing a key role in the development of POCD. Several studies suggest that age-related phenotypic change of microglia is associated with pathogenic neuroinflammation, and more importantly it may be modifiable. In this chapter, we discuss the current overview and preclinical high- lights regarding POCD. We further discuss some perspectives on preventive strategies for POCD, based on the findings of our preclinical research and the available literature.
Genome-wide analyses of sparse mediation effects under composite null hypotheses

A genome-wide mediation analysis is conducted to investigate whether epigenetic variations M mediate the effect of socioeconomic adversity S on adiposity Y . The mediation effect can be expressed as a product of two parameters: the S-M association and the M -Y association conditional on S. We show that the joint significance test examining the two parameters separately has smaller p-values than the normality-based or the normal product-based test for the product and is a size α test. However, under multiple tests with sparse signals, the conventional joint significance test has a conservative test size and low power within a study because of the sparsity in signals and not accounting for the composition of different null hypotheses. We develop a novel test assessing the product of two normally distributed test statistics under a composite null hypothesis, where either one parameter is zero or both are zero. We show that the null composition can be adjusted by variances of test statistics without directly estimating proportions of different nulls. Advantages of the new test are illustrated in simulation and the epigenomic study. The new test identifies four methylation loci mediating the socioeconomic effect on adiposity with the false discovery rate less than 20% while existing methods had none surviving this cut-off.
Dynamics of polar polarizable rotors acted upon by unipolar electromagnetic pulses: From the sudden to the adiabatic regime.

We study, analytically as well as numerically, the dynamics that arises from the interaction of a polar polarizable rigid rotor with single unipolar electromagnetic pulses of varying length, Δτ, with respect to the rotational period of the rotor, τ r . In the sudden, non-adiabatic limit, Δτ ≪ τ r , we derive analytic expressions for the rotor's wavefunctions, kinetic energies, and field-free evolution of orientation and alignment. We verify the analytic results by solving the corresponding time-dependent Schrödinger equation numerically and extend the temporal range of the interactions considered all the way to the adiabatic limit, Δτ > τ r , where general analytic solutions beyond the field-free case are no longer available. The effects of the orienting and aligning interactions as well as of their combination on the post-pulse populations of the rotational states are visualized as functions of the orienting and aligning kick strengths in terms of population quilts. Quantum carpets that encapsulate the evolution of the rotational wavepackets provide the space-time portraits of the resulting dynamics. The population quilts and quantum carpets reveal that purely orienting, purely aligning, or even-break combined interactions each exhibit sui generis dynamics. In the intermediate temporal regime, we find that the wavepackets as functions of the orienting and aligning kick strengths show resonances that correspond to diminished kinetic energies at particular values of the pulse duration.
THE ABDUS SALAM INTERNATIONAL CENTRE FOR THEORETICAL PHYSICS ZERO-SUM FLOWS IN DESIGNS

Let D be a t-(v, k, λ) design and let Ni(D), for 1 ≤ i ≤ t, be the higher incidence matrix of D, a (0, 1)-matrix of size ( v i ) × b, where b is the number of blocks of D. A zero-sum flow of D is a nowhere-zero real vector in the null space of N1(D). A zero-sum k-flow of D is a zero-sum flow with values in {±1, . ,±(k − 1)}. In this paper we show that every non-symmetric design admits an integral zero-sum flow, and consequently we conjecture that every non-symmetric design admits a zero-sum 5-flow. Similarly, the definition of zero-sum flow can be extended to Ni(D), 1 ≤ i ≤ t. Let D = t-(v, k, ( v−t k−t ) ) be the complete design. We conjecture that Nt(D) admits a zero-sum 3-flow and prove this conjecture for t = 2.
Immunohistochemical Expression of CD 8 , CDX 2 , P 53 , D 2-40 and KI 67 in Colorectal Adenocarcinoma , Conventional and Malignant Colorectal Polyps

CRISTIAN MESINA1, LIVIU CATALIN STOEAN2, RUXANDRA STOEAN2, VICTOR ADRIAN SANDITA2, CORINA LAVINIA GRUIA3, MARIA CAMELIA FOARFA3, LUCIANA TEODORA ROTARU4, ALINA ELENA CIOBANU5, MIHAI MESINA6, VERONICA CALBOREAN7*, VICTOR GHEORMAN8, DANIELA CIOBANU9 1University of Medicine and Pharmacy of Craiova, Surgery Department, Emergency County Hospital, Craiova, Romania Romania, 2-4 Petru Rares Str. , 200349, Craiova, Romania 2 University of Craiova, Computer Science Department, Faculty of Mathematics and Natural Sciences Romania, 13 AI. I. Cuza Str. , 200585, Craiova, Romania 3 Emergency County Hospital, Laboratory of Pathology, Craiova, Romania, 1 Tabaci Str. , 200642, Craiova, Romania 4University of Medicine and Pharmacy of Craiova, Emergency County Hospital, Emergency Department, 2-4 Petru Rares Str. , 200349, Craiova, Romania 5 County Hospital Craiova, Physical Medicine Department, 1 Tabaci Str. , 200642, Craiova, Romania 6 Clinical Institute Fundeni Bucharest, Cardiovascular Surgery Department, Romania, 258 Fundeni Str. ,022328, Bucharest, Romania 7Cardiology Department, County Hospital Craiova, Romania, 2-4 Petru Rares Str. , 200349, Craiova, Romania 8Neuropsychiatry Hospital of Craiova, Psychiatry Department, 24 Potelu Alley, 200317, Craiova, Romania 9 University of Medicine and Pharmacy of Craiova, Emergency County Hospital, Internal Medicine Department, 2-4 Petru Rares Str. , 200349, Craiova, Romania
Isolation and immunochemical Characterization of polar Lipids from selected probiotic Bacteria using Supercritical Carbon Dioxide

using Supercritical Carbon Dioxide GALINA NOVIK a,b* and ESTERA SZWAJCER DEY b Institute of Microbiology, National Academy of Sciences of Belarus, Kuprevich 2, 220141 Minsk, Belarus Lund University, Pure and Applied Biochemistry, Box 124, 212 00 Lund, Sweden
Social Inquiry into Well-being Effective communication as a fundamental aspect of active aging and well-being: Paying attention to the challenges older adults face in noisy environments

Successful communication is vital to active aging and well-being. Yet virtually all older adults find it challenging to communicate effectively in noisy environments. The resulting discomfort and frustration can prompt withdrawal or avoidance of social situations, which, in turn, can severely limit the range of activities available to older adults, lead to a less active and satisfying life style, and, in some cases, depression. Using the International Classification of Functioning, Disability and Health’s (ICF) multifactorial model (WHO, 2001), we review the wider aspects of functioning and disability as they relate to hearing difficulties and communication, placing a particular emphasis on the work we, an international and interdisciplinary group of researchers, have done in the context of the ERA-NET funded interdisciplinary HEARATTN project. The ICF model is particularly fitting because it allows us to consider how physiological changes in hearing and cognition affect listening in various situations, what the consequences of these changes are for communicative abilities and social participation, and how this in turn affects life-space mobility, self-reported well-being, and, ultimately, quality of life. We will discuss how environmental conditions (both physical and social) and personal factors can affect how well older adults can communicate in the situations characteristic of everyday life. In the concluding section we discuss some behaviors, techniques and strategies that can be adopted to maintain or improve effective communication under difficult listening conditions.
THE Sol-Eu-Net PROJECT DATA MINING LESSONS LEARNED

This paper reports on data mining experiences of the 5th Framework project Data Mining and Decision Support for Business Competitiveness: A European Virtual Enterprise (Sol-Eu-Net). The data mining lessons learned are reported from the following perspectives: application results, business, views of SolEu-Net partners acquired by interview technique, and lessons learned in two particular data mining projects: analysis of Web education materials and UK traffic accident data analysis.
Childhood malignant tumours in owerri: A histopathological review

Results: A total of 27 cases of malignant diseases of children were clinically diagnosed and histologically confirmed. The mean age of the patients were 10.17±4.33 years with age range of 1 to 18 years. The male to female ratio was 1:1.25. The peak age of incidence falls in the 6-10 age groups which accounted for 40.74%. Wilm’s tumor (Nephroblastoma) was the commonest 8 cases (29.63%), Embryonal Rhabdomyosarcoma 6 cases (22.22%), Neuroblastoma 4cases (14.81%), osteosarcoma 3cases (11.11%), yolk sac tumour of the ovary 2 cases (7.41%), one case “3.70%” each for retinoblastoma, soft tissue sarcoma and angiosarcoma
Nucleation of colloidal crystals on configurable seed structures

Nucleation is an important stage in the growth of crystals. During this stage, the structure and orientation of a crystal are determined. However, short time- and length-scales make nucleation poorly understood. Micrometer-sized colloidal particles form an ideal model system to study nucleation due to more experimentally accessible time- and length-scales and the possibility to manipulate them individually. Here we report experiments and simulations on nucleation in the bulk of a hard-sphere fluid, initiated by seed structures configured using optical tweezers. We find that the defect topology of the critical nucleus determines the crystal morphology. From the growth of the crystals beyond the critical nucleus size, new insights into the role of defects in crystal growth were gained that are incompatible with the assumption of equilibrium growth. These results explain the complex crystal morphologies observed in experiments on hard spheres.
The DEEP2 Galaxy Redshift Survey: Discovery of Luminous, Metal-poor Star-forming Galaxies at Redshifts z ~ 0.7

We have discovered a sample of 17 metal-poor, yet luminous, star-forming galaxies at redshifts z ~ 0.7. They were selected from the initial phase of the DEEP2 survey of 3900 galaxies and the Team Keck Redshift Survey (TKRS) of 1536 galaxies as those showing the temperature-sensitive [O III] λ4363 auroral line. These rare galaxies have blue luminosities close to L*, high star formation rates of 5-12 M☉ yr-1, and oxygen abundances of 1/3 to 1/10 solar. They thus lie significantly off the luminosity-metallicity relation found previously for field galaxies with strong emission lines at redshifts z ~ 0.7. The prior surveys relied on indirect, empirical calibrations of the R23 diagnostic and the assumption that luminous galaxies are not metal-poor. Our discovery suggests that this assumption is sometimes invalid. As a class, these newly discovered galaxies are (1) more metal-poor than common classes of bright emission-line galaxies at z ~ 0.7 or at the present epoch; (2) comparable in metallicity to z ~ 3 Lyman break galaxies but less luminous; and (3) comparable in metallicity to local metal-poor extreme blue compact galaxies (XBCGs), but more luminous. Together, the three samples suggest that the most luminous, metal-poor, compact galaxies become fainter over time.
Perfil Fisiológico de un Múltiple Campeón de Ciclismo en el Tour de Francia

Introducción: Este estudio de caso describirá una serie de características fisiológicas de un doble campeón del Tour de Francia. Métodos: Después de la evaluación de composición corporal (DEXA), se realizaron dos tests de ciclismo submáximo con etapas en dos condiciones diferentes; a temperatura ambiente (20 °C, 40%) y en un ambiente caliente y húmedo (30 °C, 60% [HH]) a partir de los cuales se realizaron mediciones de eficiencia bruta: (GE) y se calcularon los puntos de referencia de lactato -potencia y las respuestas de frecuencia cardiaca. Además, se determinaron las respuestas de termorregulación y de sudor. Además se determinó el VO2max y la producción de potencia máxima (PPO) con un test incremental con rampas hasta el agotamiento que se realizó por separado. Resultados: EL VO2max y la PPO fueron 5,91 L min (84 ml kg min ) y 525 W respectivamente, mientras que la GE media fue 23,0% y 23,6% para las condiciones de temperatura ambiente y HH respectivamente. Además de una mayor GE se observó que la producción de potencia en 4 mmol L-1 de lactato sanguíneo fue mayor en la condición HH que en la condición de temperatura ambiente (429,6 W vs. 419,0 W) lo que coincide con los informes anecdóticos de que el participante tenía un buen rendimiento en condiciones de calor. La temperatura máxima del core y de la piel, la tasa de sudoración y el contenido de electrolitos fueron mayores en la condición HH. El porcentaje de grasa corporal fue de 9,5%, mientras que la masa grasa total, masa magra y el contenido mineral óseo fue de 6,7, 61,5 y 2,8 kg, respectivamente. Conclusión: La fisiología aeróbica y los valores observados de producción de potencia se encuentran entre los más altos reportados para los ciclistas profesionales de ruta. Cabe destacar que el participante mostró un elevado VO2max y una elevada GE, algo poco común entre los ciclistas de élite, y esto podría ser un factor beneficioso para su éxito en el ciclismo de élite. Además, el rendimiento en condiciones HH fue sólido, lo que sugiere una fisiología de termorregulación eficaz. En resumen, este es el primer estudio que describe las características fisiológicas de un múltiple campeón del Tour de Francia que se encontraba cerca de condiciones máximas y sugiere cuáles pueden ser las capacidades fisiológicas y de regulación térmica necesarias para el éxito en este nivel.
Quadratic Chabauty and Rational Points II: Generalised Height Functions on Selmer Varieties

We give new instances where Chabauty–Kim sets can be proved to be finite, by developing a notion of “generalised height functions” on Selmer varieties. We also explain how to compute these generalised heights in terms of iterated integrals and give the 1st explicit nonabelian Chabauty result for a curve $X/\mathbb{Q}$ whose Jacobian has Mordell–Weil rank larger than its genus.
New C*‐completions of discrete groups and related spaces

Let Γ be a discrete group. To every ideal in ℓ∞(Γ), we associate a C*‐algebra completion of the group ring that encapsulates the unitary representations with matrix coefficients belonging to the ideal. The general framework we develop unifies some classical results and leads to new insights. For example, we give the first C*‐algebraic characterization of a‐T‐menability; a new characterization of property (T); new examples of ‘exotic’ quantum groups; and, after extending our construction to transformation groupoids, we improve and simplify a recent result of Douglas and Nowak [‘Hilbert C*‐modules and amenable actions’, Studia Math. 199 (2010) 185–197].
The Disposable Porous Bed Viscometer: A New Method for Measuring Blood Viscosity.

Abstract : A disposable porous bed viscometer (PBV) that has rheologic properties related to that of the microvasculature has recently been developed for the measurement of whole blood viscosity (WBV) under conditions of low shear and low stress. The measured endpoint of apparent viscosity with the PBV is the time for a given volume of whole blood to flow a calibrated distance through the porous bed. The various conditions of sample collection, sample storage and temperature required to obtain accurate and reproducible results with the PBV are described. The mean WBV of 242 normal persons was 22.7 +/- 5.3 seconds corresponding to an apparent viscosity of 5.7 +/- 1.3 centipoise, a value in general agreement with previous studies obtained using rotational viscometers. There was, as expected, a significant difference in the WBV of normal men and women related to their different packed cell volumes. Platelets and granulocytes also influenced WBV, but in proportion to their contribution to the total packed cell volume. In normal subjects, fibrinogen level did not significantly influence WBV. The PBV is a rapid and reproducible means to measure WBV in normal populations which should have clinical application in disorders in which ease of performance and replication is an important consideration.
Sequence comparison in computational historical linguistics

With increasing amounts of digitally available data from all over the world, manual annotation of cognates in multi-lingual word lists becomes more and more time-consuming in historical linguistics. Using available software packages to pre-process the data prior to manual analysis can drastically speed-up the process of cognate detection. Furthermore, it allows us to get a quick overview on data which have not yet been intensively studied by experts. LingPy is a Python library which provides a large arsenal of routines for sequence comparison in historical linguistics. With LingPy, linguists can not only automatically search for cognates in lexical data, but they can also align the automatically identified words, and output them in various forms, which aim at facilitating manual inspection. In this tutorial, we will briefly introduce the basic concepts behind the algorithms employed by LingPy and then illustrate in concrete workflows how automatic sequence comparison can be applied to multi-lingual word lists. The goal is to provide the readers with all information they need to (1) carry out cognate detection and alignment analyses in LingPy, (2) select the appropriate algorithms for the appropriate task, (3) evaluate how well automatic cognate detection algorithms perform compared to experts, and (4) export their data into various formats useful for additional analyses or data sharing. While basic knowledge of the Python language is useful for all analyses, our tutorial is structured in such a way that scholars with basic knowledge of computing can follow through all steps as well.
SCTP-MANET New Extension of SCTP Protocol for the Optimization of MANET Performances

Ad Hoc mobile networks are constituted of nodes that move freely without a centralized administration. These nodes contribute in the routing of data packets that are sent by a source. This happens when the latter is not capable of reaching its destination. On the other hand, their mobility causes recurrent breakdowns of the routing paths notably with sparse MANET. In order to optimize the performance of such networks, we suggest a new extension of protocols: Stream Control Transmission Protocols (SCTP) named SCTP-MANET. Their main function is therefore to improve the availability of the links in sparse MANET protocols. This could be achieved by a better integration of Multihoming. With this aim in mind, this new extension is based on a cross-layer interface between transport and routing layers as well as the use of specific messages.
PREPARATION AND CHARACTERISATION OF ACTIVATED CARBON FROM PALM KERNEL SHELL BY PHYSICAL ACTIVATION WITH STEAM

Granular activated carbon was produced from palm kernel shell using commercial scale carbonisation and activation systems. Carbonisation was carried out using kiln earth system while activation took place in a commercial scale rotary kiln. Steam was used as oxidising agent during activation process with temperature range from 900 o C to 1000 o C. Palm kernel shell activated carbon was characterised based on proximate and ultimate analyses, thermal stability, chemical functional groups, and surface area. Scanning electron microscope was used to determine the surface morphology of the carbon products. It was found that palm kernel shell is a suitable material to produce activated charcoal owing to its low ash content (2.3 wt %) but high in carbon and volatile content, 23 wt % and 61.7%, respectively. The maximum thermal stability was observed up to 700 o C for palm kernel shell activated carbon and raw palm kernel shell but 600 o C for palm kernel shell charcoal. The Brunauer-Emmett-Teller (BET) surface area of palm kernel shell activated carbon produced in this study is 607.76 m² g -1 with 541.76 m² g -1 micropore area; this is comparable to commercial activated carbon with BET surface area of 690.92 m² g -1 with 469.08 m² g -1 micropore area. From the adsorption experiment, palm kernel shell activated carbon could remove up to 80.7% of chemical oxygen demand with 8.83 mg g -1 adsorption capacity; this is comparable to the performance of commercial activated carbon available in the market. The results of this study proved that good quality activated carbon can be produced from palm kernel shell.
Multiplex Taqman Real-Time Pcr For Detecting Aeromonas Hydrophila, A. Veronii and A. Schubertii

In this study, pathogenic Aeromonas hydrophila, A. veronii, and A. schubertii from fish were detected by multiplex TaqMan real-time PCR assay. The assay utilized three pairs of specific primers and three corresponding TaqMan probes designed to detect the aerolysin gene in A. hydrophila, the aerolysin gene in A. veronii, and the gyrB gene in A. schubertii. The specificity of the probe and primers was evaluated. The detectable concentration for the multiplex real-time PCR was 3.33×10 copies/μL per reaction, respectively. In addition, the coefficient of variation was less than 1.5% for both intraand inter-assay. The assay, when screened for 120 cultured fish samples, showed 76.7% positive for Aeromonas spp. and could accurately identify these bacterial strains. These results indicated that this assay could be used as an effective tool for rapid detection and epidemiology investigation of A. hydrophila, A. veronii, and A. schubertii. The IJA appears exclusively as a peer-reviewed on-line open-access journal at http://www.siamb. org.il. To read papers free of charge, please register online at registration form. Sale of IJA papers is strictly forbidden.