Miracle-dz/UniFAR-FTUs huggingface dataset:
Lactobacillus reuteri cell-free extracts against antibiotic-resistant bacteria

The aim of the research was to evaluate the antimicrobial potential of cell-free extracts obtained in various ways from the probiotic strain Lactobacillus reuteri DSM 17938 with respect to their ability to influence the proliferation of antibiotic-resistant bacteria. Materials and methods . Cell-free extracts were obtained: 1) from L. reuteri cell suspension, subjected to disintegration by repeated freezing-thawing, L; 2) from L. reuteri culture, cultivated in its own disintegrate (ML); 3) from L. reuteri culture, cultivated in its own disintegrate supplemented with glycerol (73.7 mg/ml) and glucose (72.1 mg/ml) (MLG); 4) from L. reuteri culture, cultivated in its own disintegrate supplemented with ascorbic acid (20 mg/ml) (MLA). Multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical isolates: Escherichia coli, Klebsiella pneumoniae, Lelliottia amnigena and Corynebacterium xerosis were used as a test cultures. The investigation of the inhibitory activity of cell-free extracts was carried out by spectrophotometric method using a microplate analyzer “Lisa Scan EM” (“Erba Lachema s.r.o.”,CzechRepublic). Results . Cell-free extract L exerted predominantly stimulatory effect on the proliferation of all studied test cultures. Cell-free extract ML had significant inhibitory effect on the proliferation of E. coli and C. xerosis (growth inhibition indices were 24.8 % and 96.1 %, respectively) and did not have significant effect on the proliferation of K. pneumoniae and L. amnigena. Cell-free extracts MLG and MLA caused pronounced inhibition of the proliferative activity of all tested microorganisms. Growth inhibition indices were: 75 % and 90.7 % (E. coli), 77.9 % and 88.9 % (K. pneumoniae), 40.9 % and 77.9 % (L. amnigena), 99 % and 100 % ( C. xerosis), respectively. Conclusions . The cell-free extracts obtained by cultivation of L. reuteri DSM 17938 in its own disintegrate supplemented with glycerol and glucose or ascorbic acid have shown a pronounced antimicrobial activity against antibiotic-resistant bacteria in vitro . After confirming safety and efficacy in vivo , they can be used to increase the efficiency of the therapy of diseases caused by antibiotic-resistant microorganisms. The results of the study indicate the prospects of obtaining probiotic derivatives with high antimicrobial activity by applying a combinatorial (precursor directed) biosynthesis strategy.
Effect of Plant Biostimulants on Macronutrient Content in Early Crop Potato Tubers

This paper analyzes the effects of the foliar application of the seaweed extracts Bio-algeen S90 (Ascophyllum nodosum) and Kelpak SL (Ecklonia maxima), as well as the humic and fulvic acids in HumiPlant (leonardite extract) on the macronutrient content in tubers of very early potato cultivars (‘Denar’, ‘Lord’, ‘Miłek’) and their ionic ratios. The field experiment was carried out in central-eastern Poland over three growing seasons, using Haplic Luvisol. The biostimulants were applied according to the manufacturers’ recommendations. Potatoes were harvested 75 days after planting. The use of biostimulants increased potassium (K) content in tubers, on average, by 1.26 g∙kg−1 of dry matter compared with the untreated control tubers. Bio-algeen S90 did not affect the phosphorus (P) content in tubers, whereas Kelpak SL and HumiPlant reduced the phosphorus content, on average, by 0.063 g∙kg−1 of dry matter. The biostimulants did not affect calcium (Ca), magnesium (Mg), or sodium (Na) content in tubers. The use of biostimulants resulted in an increase in the mass ratios of K+:Ca2+, K+:Mg2+, and (K+ + Na+):(Ca2+ + Mg2+) in early crop potato tubers, compared with the untreated control tubers, but did not affect the mass ratios of Na+:Ca2+ and Na+:Mg2+ or the mass ratio of Ca:P. The macronutrient content in early crop potato tubers and their ionic ratios depended on the cultivar and environment conditions.
DiabetesFlex™ – the effect of PRO-based telehealth and user involvement in care management of patients with type 1 diabetes: Trial protocol for a non-inferiority randomised controlled study

Background: This trial focuses on management of care for patients with type 1 diabetes, patient involvement and use of patient-reported outcome (PRO)-based telehealth. Despite available knowledge on the use of different kinds of PRO measures in diabetes care, studies that use PRO in remote monitoring in diabetes management are scarce. Objective: The aim of this pragmatic randomised controlled non-inferiority study is to investigate the effect using a PRO-based telehealth intervention, DiabetesFlex, on health outcome, user involvement and healthcare utilisation in patients with type 1 diabetes. Methods: This trial plans to recruit 400 patients with type 1 diabetes treated at an outpatient clinic at XXXX University Hospital. The participants will fill in an electronic questionnaire covering health outcome and patient involvement at baseline and at end of the study period (15 month). Data on HbA1c, blood pressure, urine albumin/creatinine ratio and resource (number of contacts and consultations) will be drawn from the patients’ medical records at baseline and at 4, 8, 12 and 15 months. Patients will be randomised to either DiabetesFlex™ (a patient-initiated and PRO-driven protocol) or standard care. The patient perspective on the use of DiabetesFlex™ will be explored in a qualitative study. Conclusion: This study will seek to outline significant knowledge on what matters to the people with diabetes in relation to involvement in care planning. As well as factors related to patients’ experiences concerning the use of PRO measures. This is important components in diabetes care management. Trial registration: ClinicalTrials.gov. NCT03202732
A Regional Sn Magnitude Scale mb(Sn) and Estimates of Moment Magnitude for Earthquakes along the Northern Mid-Atlantic Ridge

We present a regional short-period Sn magnitude scale mb(Sn) for small earthquakes along the northern Mid-Atlantic Ridge. Surface-wave magnitudes, teleseismic body-wave magnitudes, and seismic moments cannot be reliably determined for small earthquakes along this and other midocean ridges. Local magnitudes that rely on Lg waves are likewise not generally useful due to the substantial oceanic paths for earthquakes along midocean ridges. In contrast, Pn and Sn arrivals for earthquakes along the northern Mid-Atlantic Ridge are generally well recorded by the existing seismographic networks, and, in fact, Sn arrivals are larger than Pn arrivals for about one-third of the ridge events. For this reason, we have developed a new regional Sn magnitude scale that is tied to Mw, so that seismic moments can be readily approximated. In our least-squares fit of peak amplitudes from 120 earthquakes having a published moment magnitude, we solved for the attenuation curve for paths in the oceanic mantle lid, for event magnitude adjustments (EMAs) to account for differences between long-period moment magnitude Mw and short-period Sn magnitude, and for station corrections. We find regional EMAs that are well correlated with the style of faulting: they are positive for normal-faulting earthquakes along spreading ridges and negative for strike-slip earthquakes along transform faults. These source-specific EMAs are approximately +0.11 magnitude units for normal-fault earthquakes and −0.26 magnitude units for strike-slip earthquakes on transform faults, and are consistent with previously reported apparent stresses from these regions. The amplitude distance curve determined for Sn for the northern Atlantic Ocean is similar to that determined for Pn in the northern Atlantic out to a distance of about 500 km, but at larger distances is more similar to the western U.S. Pn curve, likely reflective of the warmer temperatures at greater upper-mantle depths.
Electroencephalogram classification in motor-imagery brain–computer interface applications based on double-constraint nonnegative matrix factorization

Objective: Brain–computer interfaces (BCIs) are aimed at providing a new way of communication between the human brain and external devices. One of the major tasks associated with the BCI system is to improve classification performance of the motor imagery (MI) signal. Electroencephalogram (EEG) signals are widely used for the MI BCI system. The raw EEG signals are usually non-stationary time series with weak class properties, degrading the classification performance. Approach: Nonnegative matrix factorization (NMF) has been successfully applied to pattern extraction which provides meaningful data presentation. However, NMF is unsupervised and cannot make use of the label information. Based on the label information of MI EEG data, we propose a novel method, called double-constrained nonnegative matrix factorization (DCNMF), to improve the classification performance of NMF on MI BCI. The proposed method constructs a couple of label matrices as the constraints on the NMF procedure to make the EEGs with the same class labels have the similar representation in the low-dimensional space, while the EEGs with different class labels have dissimilar representations as much as possible. Accordingly, the extracted features obtain obvious class properties, which are optimal to the classification of MI EEG. Main results: This study is conducted on the BCI competition III datasets (I and IVa). The proposed method helps to achieve a higher average accuracy across two datasets (79.00% for dataset I, 77.78% for dataset IVa); its performance is about 10% better than the existing studies in the literature. Significance: Our study provides a novel solution for MI BCI analysis from the perspective of label constraint; it provides convenience for semi-supervised learning of features and significantly improves the classification performance.
Caracterização de genótipos de pimentas Capsicum spp. durante a maturação.

Este trabalho teve como objetivo caracterizar fisica e fisico-quimicamente os frutos de 14 genotipos de pimenteira Capsicum spp. pertencentes ao Banco Ativo de Germoplasma da Embrapa Amazonia Oriental, a fim de colher subsidios que permitam avancar com o programa de melhoramento genetico. Os materiais foram caracterizados quanto a dimensao e peso dos frutos, cor, umidade, pH e acidez titulavel. As caracteristicas fisico-quimicas foram determinadas em dois estadios de maturacao (frutos imaturos e completamente maduros). Os frutos maduros apresentaram variabilidade de cor, comprimento, diâmetro e peso. A cor variou do amarelo ate o vermelho intenso, o comprimento de 9,05 a 46,75 mm, o diâmetro de 6,83 a 25,34 mm e o peso de 0,40 a 12,10 g. Os valores de pH, acidez titulavel e umidade diferiram significativamente entre os genotipos e com o estadio de maturacao dos frutos.
A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations

Abstract Hallucinations can occur in different sensory modalities, both simultaneously and serially in time. They have typically been studied in clinical populations as phenomena occurring in a single sensory modality. Hallucinatory experiences occurring in multiple sensory systems—multimodal hallucinations (MMHs)—are more prevalent than previously thought and may have greater adverse impact than unimodal ones, but they remain relatively underresearched. Here, we review and discuss: (1) the definition and categorization of both serial and simultaneous MMHs, (2) available assessment tools and how they can be improved, and (3) the explanatory power that current hallucination theories have for MMHs. Overall, we suggest that current models need to be updated or developed to account for MMHs and to inform research into the underlying processes of such hallucinatory phenomena. We make recommendations for future research and for clinical practice, including the need for service user involvement and for better assessment tools that can reliably measure MMHs and distinguish them from other related phenomena.
Influencia del genotipo y la fertilización sobre el rendimiento en grano de trigo pan y su calidad en la región subhúmeda-seca pampeana

El rendimiento en grano y la calidad de trigo pan muestran gran variabilidad en la region subhumeda seca pampeana. El objetivo de este trabajo fue evaluar el efecto del genotipo y la fertilizacion nitrogenada sobre los componentes del rendimiento y la calidad del grano. Los ensayos se realizaron en la Facultad de Agronomia de la UNLPam (36° 32’ 49” S; 64° 18’ 20” W) durante 2 anos, 16 genotipos con distinto ano de inscripcion en el INASE. Al tratamiento fertilizado se le agrego 100 kg.ha -1 de urea al voleo en macollaje temprano y el control se mantuvo sin fertilizar. Los resultados no mostraron una asociacion entre el grupo de calidad de la variedad y el rendimiento en grano o el porcentaje de proteinas. El fertilizante nitrogenado agregado en el macollaje aumento en los dos anos estudiados el porcentaje de proteina, mientras que contribuyo al rendimiento en grano solo en el ano mas lluvioso. Tampoco hubo una clara asociacion entre el ano de inscripcion de la variedad en INASE y el rendimiento de grano o el porcentaje de proteinas, indicando escaso progreso genetico de los criaderos para la region subhumedaseca pampeana. Se concluyo que el genotipo elegido, en lo referente a grupo de calidad y ano de inscripcion, no es tan importante, sobre el rendimiento y la calidad del grano como el efecto de la estacion de crecimiento y la fertilizacion nitrogenada.
InfluenceRank: An Improved Online Social Influence Model

User influence is a popular research content in online social networks, and it plays an important role in marketing, public opinion management, and network relationships. Traditional research on user influence based on graph structure mainly considers whether users follow each other. However, "zombie fans" can make the influence analysis results inaccurate. Based on the PageRank algorithm, this study proposes a novel model for measuring user influence: InfluenceRank. User behavior and interaction information are introduced into the model through three indicators: activity, interaction and credibility. The experimental results, which are more comprehensive and persuasive, prove that the influence ranking of the InfluenceRank model on Microblog (Chinese Twitter) users is not limited to the number of users' fans.
Action planning and affective states within the auditory peripersonal space

Fast reaction to approaching stimuli is vital for survival as for sounds entering the individual auditory Peripersonal Space (PPS). Closer sounds have found to provoke higher motor cortex activation particularly for highly arousing sounds, showing the close relationship for perceptual components of the sounds and motor preparation. Here Normal Hearing (NH) individuals and Cochlear Implanted (CI) individuals have been compared in their ability to recognize evaluate and react to affective stimuli entering the PPS. Twenty (seven females) NH and ten (three females) CI participants were asked to react to Positive (P), Negative (Ne), Neutral, (Nu) affective sounds virtually ending at five different distances from their body by performing fast arms flexion. Pre-motor Reaction Times (pm-RTs) were detected via EMG from postural muscles to measure action anticipation at different sound stopping distances; furthermore, the same sounds were evaluated for their level of valence and arousal perceived. Both groups showed the ability to localize the sound distances but only NH individuals modulated their pm-RTs based on the sound distance. Interestingly when the sound was not carrying affective components, as for Nu sounds, both NH and CI individuals triggered the promptest pre-motor reaction time (shorter pm-RT) when compared to P and N sounds. Only NH individuals modulated sound distance with the level of sound arousal, while sound’s valence was similarly perceived by both NH and CI individuals. These results underline the role of emotional states in action preparation and describe the specific perceptual components necessary to properly react to approaching sounds within peripersonal space.
Risks and disease aetiologies of compromised performance in commercial broilers kept at lower stocking density and limited antimicrobial use

ABSTRACT The health status of broilers raised at lower stocking density and limited antimicrobial use (but routine anticoccidials) was assessed in order to identify prevalent causes of disease, mortality and reduced performance. “Dead-on-farm”(DOF) broilers from 145 commercial flocks were investigated at two different time points (TP1:7–14 and TP2:28–35 days of age); per sampling, 6–10 DOF broilers were selected for post-mortem investigation and gross pathomorphological changes were assessed from 2717 birds in total. Post-mortem findings were substantiated by bacteriological, virological and parasitological investigations. Furthermore, production data of all flocks were collected and used to perform comprehensive statistical analysis. Overall, colibacillosis was found most important with a significant negative impact on flock health, productivity and profitability through all ages of broiler production. At TP1, primary reasons for mortality comprised yolk sac infections, generally found together with fibrinous polyserositis due to E. coli. Furthermore, femoral lesions, which correlated with increased flock mortality, were associated with detection of E. coli. At TP2, ascites was detected frequently in DOF broilers, correlating with increased production losses in the fourth and fifth weeks of life. No aetiological link between the presence of ascites and the detection of the investigated pathogens was observed, instead a positive correlation was noticed with altitude above sea level of the farm, and with the sex of the birds. Disease conditions could not be linked with the housing system. Presence of infectious bronchitis virus, avian reovirus and fowl adenovirus did not correlate with macroscopic lesions or a specific disease. RESEARCH HIGHLIGHTS In young broilers lesions of visceral organs due to bacterial infections dominated. Colibacillosis impacts broiler health, productivity and profitability independent of the age of birds. Disorders of the locomotor system were frequently observed throughout production. Older broilers frequently showed pathologic changes due to metabolic disorders. Overall, a shift from infectious towards metabolic disease conditions was noticed.
Incivilidade no processo de trabalho da enfermagem

Objetivo : discutir sobre a incivilidade no processo de trabalho dos profissionais de enfermagem. Para isso, foram elaborados pontos norteadores para apoiar a reflexao do estudo, sendo eles: a civilidade e a incivilidade no trabalho e a incivilidade no trabalho da enfermagem. Desenvolvimento : A incivilidade nao e um comportamento recente na enfermagem, e denominada como uma hostilidade ou violencia horizontal, descrita como comportamento hostil, agressivo, por um enfermeiro ou grupo de enfermeiros, em direcao a outro enfermeiro ou a um grupo, por meio de disputas internas, atitudes como rudeza ao falar com colega, resposta sarcastica, desrespeito as confidencias e a privacidade. Conclusao : o comportamento incivil faz parte da rotina diaria dos profissionais de enfermagem, causando prejuizo tanto para os trabalhadores como para a instituicao de saude. Torna-se importante que esse assunto seja amplamente discutido nas instituicoes, com foco na reducao da incivilidade entre os enfermeiros e demais profissionais da saude. Descritores: Incivilidade; Trabalho; Enfermagem; Hospital; Saude do trabalhador. Objective : To discuss the incivility in the work process of nursing professionals. For this, guiding points were elaborated to support the reflection of the study, namely: civility and work incivility and nursing work incivility. Development : Incivility is not a recent behavior in nursing, it is termed as horizontal hostility or violence, described as hostile, aggressive behavior by one nurse or group of nurses toward another nurse or group through disputes. internal, attitudes such as rudeness in talking with colleague, sarcastic response, disrespect for confidentiality and privacy. Conclusion : Incivil behavior is part of the daily routine of nursing professionals, causing harm to both workers and the health institution. It is important that this issue be widely discussed in institutions, focusing on reducing incivility among nurses and other health professionals. Keywords : Incivility; Job; Nursing; Hospital; Worker's health. Objetivo: Discutir la incivilidad en el proceso de trabajo de los profesionales de enfermeria. Para esto, se elaboraron puntos de guia para apoyar la reflexion del estudio, a saber: civilidad e incivilidad laboral e incivilidad laboral de enfermeria. Desarrollo : La incivilidad no es un comportamiento reciente en enfermeria, se denomina hostilidad o violencia horizontal, descrita como comportamiento hostil y agresivo por una enfermera o grupo de enfermeras hacia otra enfermera o grupo a traves de disputas. internas, actitudes como la groseria al hablar con un colega, la respuesta sarcastica, la falta de respeto a la confidencialidad y la privacidad. Conclusion : el comportamiento incivil es parte de la rutina diaria de los profesionales de enfermeria, causando dano tanto a los trabajadores como a la institucion de salud. Es importante que este tema sea ampliamente discutido en las instituciones, enfocandose en reducir la incivilidad entre las enfermeras y otros profesionales de la salud. Palabras clave: Incivilidad; Trabajo; Enfermeria; Hospital; Salud del trabajador.
Chemical Composition of the Essential Oil of Micromeria libanotica Boiss., an Endemic Species of Lebanon

Abstract The essential oil obtained by steam distillation from Micromeria libanotica growing wild in the cedar mountains of Lebanon, was examined by GC and GC/MS. Twenty-five components, representing about 83% of the oil were identified. The major constituents of the oil were found to be the monoterpene ketones isomenthone (44.5%), pulegone (13.5%) and isopulegone (6.5%).
Managing change: role of leadership and diversity management

PurposeThe lived paid work experiences of two women (a European Canadian-born and a South Asian immigrant) demonstrate how low-quality leader–member exchanges and poor diversity management negatively influence employees' health, job satisfaction and retention during a period of major organizational change.Design/methodology/approachThis paper combined a narrative case study with auto ethnography to examine the lived paid work experiences of the two female authors and identify common patterns of meaning within the data.FindingsThe analysis of personalized accounts demonstrate the damaging results of a failed change management initiative when leaders did not follow an organizational change model and used an authoritarian leadership style. Further, the low-quality leader–member exchanges and poor diversity management reduced authors' feelings of inclusion and negatively impacted their emotional and physical health, job satisfaction, and retention.Research limitations/implicationsNew knowledge gained about leader–member exchange and diversity management has implications not only for leaders, but also human service managers. The data represents the authors' two perspectives, constraining generalizability. Larger samples of employees' narratives from diverse cultural/work backgrounds would be valuable to inform organizational change.Practical implicationsThe paper provides practical reasons for leadership training and skill development in change management models.Social implicationsGiven global demographic diversity, the findings are relevant to organizations, highlighting the importance of creating a climate of inclusion for workers' job satisfaction and retention and organizational success.Originality/valueWhile the sample size (n = 2) is very small, using a combination of personal experience methods offered insights into the complexity of leader–member exchange and diversity management from workers' perspectives, and went beyond successful cases, adding value to organizational change research.