Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute effects of 17 beta-estradiol on the rat heart.

OBJECTIVE Our purpose was to study the acute effects of 17 beta-estradiol on mechanical and electrical activities of cardiac function and on coronary arteries in the rat heart. STUDY DESIGN The effects of 17 beta-estradiol were studied on perfused working heart isolated from Charles River male rats. Heart rates, coronary flow, aortic flow, and left ventricular pressure were measured. To avoid coronary interaction, chronotropic and inotropic effects were also tested on isolated atria. Data were analyzed with the paired Student t test. RESULTS 17 beta-Estradiol produced a dose-dependent negative chronotropic effect in right atria but did not affect the contractility of left atria. A decrease in heart rate was also observed in perfused hearts treated with 5 x 10(-6) mol/L 17 beta-estradiol. 17 beta-Estradiol (5 x 10(-6) mol/L) significantly increased coronary flow (p < 0.005) but had a negligible effect on cardiodynamic index values. A significant effect of 17 beta-estradiol on cardiac function was observed when coronary arteries were precontracted with acetylcholine. CONCLUSION Both the experimental coronary vasodilatory effect and the negative chronotropic effect of 17 beta-estradiol support the clinical observations that suggest that this hormone may have an important role in prevention of cardiovascular diseases.
hOGG1 polymorphism and loss of heterozygosity (LOH): Significance for lung cancer susceptibility in a caucasian population

Oxidative damage is implicated in several chronic diseases including cancer. 8‐Hydroxyguanine (8‐oxoG) is one of the major promutagenic DNA lesions, which is produced by reactive oxygen species, causes G:C to T:A transversions and is excised by OGG1, an 8‐oxoG specific DNA glycosylase/AP−Lyase. In a nested case‐control study, gDNA from 105 Caucasian primary non‐small cell lung cancer cases and 105 matched controls was screened for 6 possible new polymorphic sites in the human OGG1 gene, detected previously mainly in tumour tissue. The previously described Ser326Cys polymorphism was found to be common (allele frequency 0.22) in Caucasians. However, no major difference in Ser326Cys genotype distribution could be detected between cases and controls. Two 5`‐end polymorphisms previously found in Japanese as well as Arg131Gln could not be detected in this population. An Ala85Ser polymorphism was found in 2 controls, whereas Arg46Gln was detected in only 1 case. As the hOGG1 gene is mapped (3p26.2) to a region frequently lost in primary lung tumours, the frequency of loss of heterozygosity (LOH) was investigated. Forty‐three percent of the studied lung tumours exhibited loss of one of the hOGG1 alleles. The wt Ser326 allele was not predominantly lost in our sample set, which suggests a minor role of this polymorphism in tumourgenesis. Our results show that LOH at the hOGG1 gene locus is a very common occurrence in lung tumourgenesis, possibly leading to increased mutational damage due to ROS in smokers. However, the hOGG1 polymorphisms studied are probably not major contributors to individual lung cancer susceptibility in Caucasians. Int. J. Cancer 88:932–937, 2000. © 2000 Wiley‐Liss, Inc.
Efficient fault-prone software modules selection based on complexity metrics

In order to improve the software reliability early, this paper proposes an efficient algorithm to select fault-prone software module. Based on software module's complexity metrics, the algorithm uses modified cascaded-correlation algorithm as neural network classifier to select the fault-prone software module. Finally, by analyzing the algorithm's application in the project MAP, the paper shows the advantage of the algorithm.
Wheat bread biofortification with rootlets, a malting by-product.

BACKGROUND Barley rootlets, a malting by-product, are currently discarded or used as fodder. In this study, milled rootlets and Lactobacillus plantarum FST 1.7-fermented rootlets were incorporated into wheat bread. The objective was to formulate a high-nutrition alternative to wholemeal breads with improved technological attributes. RESULTS Chemical analyses showed that rootlets contribute nutrients and bioactive compounds, including proteins, amino acids, fatty acids, carbohydrates, dietary fibre, polyphenols and minerals. Rootlets are particularly rich in essential amino acids, especially lysine, the typically limiting essential amino acid of cereals. Additionally, rootlets offer potential dietary fibre health benefits such as protection against cardiovascular disease, cancers and digestive disorders. CONCLUSION Breads prepared with a (fermented) rootlet inclusion level of up to 10% compared favourably with wholemeal breads from nutritive, technological and textural perspectives. Furthermore, they were well accepted by sensory panellists. Using rootlets as a food ingredient would have the added benefit of increasing this malting by-product's market value.
Hybrid decision and data adaptive antenna array processing for collision avoidance radar

In this paper we describe a hybrid data and decision adaptive beam forming and processing strategy using a novel W-band (75-84 GHz) phased array architecture for automotive collision avoidance radars. We use the term `decision adaptive' to denote the situation where the output of a tracking algorithm initializes the weight vector of the antenna array such that the main formed beam can be coarsely steered toward a desired, conjectured target location and clutter can be nulled. We use `data adaptive' in the classic sense where the structure of the data provides fine angular resolution target angle estimates. This is also known as digital beamforming (DBF). This type of approach has three advantages for an automotive radar system: 1) the coarse direction beam weights are stored a priori and a simple look up table is used which makes real time computation trivial; 2) the DBF algorithm is applied at a lower dimension which alleviates both training and computation burdens; and 3) a simplified antenna array system can be used in which the various antenna channels are weighted and pre-combined into subarrays prior to the receiver electronics. This reduces on-chip real estate burden in manufacturing. We will show via analysis and simulation the performance of such a system.
The Problem of Agency Re-visited

We analyze five commentaries to our "Socio-theoretic Accounts of IS: The Problem of Agency" paper. We find more commonalty in the way we think about theory and theory development in the IS field than expected, and clear up some misconceptions about our intentions. Actor network IS theorists are reluctant to accept the way we frame the problem of agency and we con- sider some of their arguments and propose counter arguments.
Fanconi anemia (FA) and crosslinker sensitivity: Re‐appraising the origins of FA definition

The commonly accepted definition of Fanconi anemia (FA) relying on DNA repair deficiency is submitted to a critical review starting from the early reports pointing to mitomycin C bioactivation and to the toxicity mechanisms of diepoxybutane and a group of nitrogen mustards causing DNA crosslinks in FA cells. A critical analysis of the literature prompts revisiting the FA phenotype and crosslinker sensitivity in terms of an oxidative stress (OS) background, redox‐related anomalies of FA (FANC) proteins, and mitochondrial dysfunction. This re‐appraisal of FA basic defect might lead to innovative approaches both in elucidating FA phenotypes and in clinical management. Pediatr Blood Cancer 2015;62:1137–1143. © 2015 Wiley Periodicals, Inc.
Power enhancement of micro thermoelectric generators by micro fluidic heat transfer packaging

This paper reports the design, fabrication and proof of concept of a multilayer fluidic packaging system enabling an increase in the output power performance of micro thermoelectric generators (μTEGs). The complete integration of the fluidic heat transfer system (HTS) with a μTEG is successfully demonstrated. The fabricated μHTS prototypes were tested with respect to their heat transfer resistance and consumed pumping power. A heat transfer resistance of 0.48cm<sup>2</sup>K/W was achieved with a small pumping power of 3.7mW/cm<sup>2</sup>. This results in a potential μTEG power output enhancement of 38 times at a heat source temperature of 320K, cold side temperature of 300K and a thermoelectric figure of merit (Z) of 1.1×10<sup>−3</sup> K<sup>−1</sup>.
Increased cancer risk in patients with haemophilia A: a nationwide population‐based 14‐year study in Taiwan

Haemostasis is associated with the development and dissemination of cancer. Whether cancer incidence is increased in haemophiliacs remains uncertain; thus, we aimed to further examine this issue. By using data from the National Health Insurance Research Database in Taiwan, we obtained a cohort of 683 patients with haemophilia A, and compared the incidence rate ratio (IRR) of cancer in this cohort with an age‐ and sex‐matched control of 6830 patients. The log‐rank test was used to compare Kaplan–Meier curve of the cumulative cancer incidence between two cohorts. Cox regressions were used to identify independent risk factors of cancer in the study patients. The cancer incidence of patients with haemophilia A was significantly higher compared to the control group (IRR 1.95, 95% CI 1.18–3.09, P = 0.008) during the 14‐year follow‐up period. The non‐lymphoma and non‐liver cancer incidence in the haemophilia A cohort remained higher than that of the matched control (P = 0.050 by the log‐rank test). The multivariate Cox proportional hazards analysis indicated that age (per year, HR 1.09, 95% CI 1.06–1.12, P < 0.001) was the only significant risk factor for cancer development in haemophilia patients. Patients with haemophilia A had higher cancer incidence than the age‐ and sex‐matched patients, especially for the elderly. With increasing life expectancy for haemophiliacs, physicians should be aware of their cancer development.
Nonimmediate hypersensitivity reactions to iodinated contrast media

Purpose of reviewTo provide a detailed analysis of the latest findings on the mechanisms underlying the nonimmediate reactions to iodinated contrast media and comment on the recent advances in diagnosis, focusing on the roles of the skin test, drug provocation test (DPT), and lymphocyte transformation test (LTT). Recent findingsSeveral studies have reported new findings supporting an important role for T-lymphocytes in the nonimmediate reactions to iodinated contrast media. The LTT has been used as an in-vitro tool for diagnosis, but with variable results. However, the inclusion of autologous monocyte-derived dendritic cells as professional antigen-presenting cells has improved the sensitivity of this test. Regarding in-vivo diagnosis, although skin testing has been routine, it has now been shown that its sensitivity and negative predictive value are low. Recent studies have demonstrated that the DPT is a well tolerated and useful procedure that is necessary to confirm the diagnosis of nonimmediate hypersensitivity reactions to iodinated contrast media. SummaryNonimmediate reactions to contrast media are usually T-cell mediated. Diagnosis is based on skin testing, although its sensitivity and negative predictive value are not optimal. Consequently, drug provocation testing is often needed to confirm the diagnosis and also to seek alternative contrast media that can be tolerated.
CT Assessment of Normal Splenic Size in Children

The size of the normal spleen was estimated by CT in 153 children, examined with indication unrelated to splenic disease. In each patient the width, thickness, length and volume of the spleen were calculated. Measurements were also normalized to the transverse diameter of the body of the first lumbar vertebra. The spleen underwent significant growth during the first 4 years of life and reached maximum size at the age of 13. There were no differences in splenic volume between boys and girls. Splenic thickness correlated best with normal splenic volume. The strongest correlation was also found between splenic thickness and volume in a group of 45 children with clinically evident splenomegaly. Splenic thickness, an easy-to-use measurement, may be employed in everyday practice to represent splenic volume on CT.
Analyse du contenu informatif de la divulgation des informations sur le capital immatériel : le cas des entreprises américaines

L’objectif de cette recherche est d’analyser le contenu informatif de la divulgation des informations sur le capital immateriel (CI) de l’entreprise. La methode d’analyse de contenu a ete utilisee afin de collecter les donnees sur la divulgation du CI a partir des rapports annuels de 126 entreprises americaines. A l’aide d’une serie d’analyses de correlation et de regression multiple, nos resultats montrent que les informations divulguees sur le CI, notamment celles de qualite, sont considerees comme pertinentes pour les investisseurs puisqu’elles ont un contenu informatif additionnel dans l’evaluation boursiere des entreprises. Ces resultats impliquent, par consequent, que les investisseurs percoivent le CI comme une source de valeur bien qu’il ne soit pas comptabilise parmi les actifs de l’entreprise. Nos resultats permettent, entre autres, d’encourager les dirigeants d’entreprises a divulguer volontairement de l’information sur le CI afin de pallier a l’absence de ces informations dans les etats-financiers traditionnels.
A certificación forestal en Galicia

espanolLa certificacion forestal es un proceso voluntario en el que una parte independiente (auditor) comprueba que efectivamente se puede asegurar que la madera procede de montes gestionados de forma sostenible. A este proceso se someten los propietarios o industrias de transformacion de la madera con el fin de obtener una mejora en la gestion ambiental en primer lugar pero tambien con intencion de mejorar tanto la apreciacion social de su actividad, como sus resultados economicos. Que la presencia de etiqueta sea garantia de que la madera procede de montes gestionados sosteniblemente no implica que su ausencia se deba, en todo caso, a que proceda de montes que no hayan sido gestionados asi. galegoA certificacion forestal e un proceso voluntario no que unha parte independente (auditor) comproba que efectivamente se pode asegurar que a madeira procede de montes xestionados de forma sostible. A este proceso sometense os propietarios ou industrias de transformacion da madeira co fin de obter unha mellora na xestion ambiental en primeiro lugar pero tamen con intencion de mellorar tanto a apreciacion social da sua actividade, como os seus resultados economicos. Que a presenza de etiqueta sexa garantia de que a madeira procede de montes xestionados sostiblemente non implica que a sua ausencia se deba, en todo caso, a que proceda de montes que non fosen xestionados asi.
A dual-band multimode monopulse tracking antenna for land-mobile satellite communications in Ka-band

The growing interest in bi-directional mobile satellite communications in Ka-band necessitates the development of dedicated antenna systems and feeds. In this paper we describe a mobile satellite communications terminal with a cassegrain reflector antenna fed from a multimode monopulse tracking system for circular polarisation at the satellite downlink frequency of 20 GHz. The structure is operational at 30 GHz as well, to cover the uplink frequency range. The antenna system is mounted on a high-performance mechanical positioner to facilitate a fast compensation of the movements of the carrier vehicle. This work contributes to the development of a satellite terminal for mobile communications in disaster scenarios [1].
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice.

A construct containing approximately 2500 base pairs (bp) of 5' upstream and approximately 700 bp of 3' downstream sequence was used to drive the expression of an intronless human K14 gene in vitro and in vivo. To track the expression of the gene, a small sequence encoding the antigenic portion of neuropeptide substance P was inserted in frame 5' to the TGA translation stop codon of the gene. Surprisingly, this gene was expressed promiscuously in a wide variety of cultured cells transiently transfected with the construct. In contrast, when introduced into the germ line of transgenic mice, the construct was expressed in a fashion analogous to the endogenous K14 gene--namely, in the basal layer of stratified squamous epithelia. Our results suggest that some regulatory mechanism is overridden as a consequence of transient transfection but that sequences that can control proper K14 expression are present in the construct. The appropriate tissue-specific and differentiation-specific expression of K14.P in transgenic mice is an important first step in characterizing a promoter that could be employed to drive the foreign expression of drug-related genes in the epidermis of skin grafts.
Low density lipoprotein receptor‐related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia

Objective Mutations in the low‐density lipoprotein receptor‐related protein 5 gene (LRP5) underlie osteoporosis–pseudoglioma syndrome. Animal models implicate a role for LRP5 in lipid and glucose homeostasis. The objective was to evaluate metabolic consequences of LRP5 mutations in humans.
MicroTom - A New Model System for Plant Genomics

The application of genetic modifications to economically important plant species primarily includes tolerance to broad-spectrum herbicides such as glufosinate or glyophosate, resistance to pest and diseases, high yield, biofuel production and better quality food products for consumption. Plant model systems have played an important role in understanding plant biology that leads to economic trait development in crops. The most highly developed plant model system is Arabidopsis because of its small size, rapid life cycle, small genome, and transformability. MicroTom is a miniature dwarf determinate tomato cultivar, originally bred for home gardening purposes, which shares the major features with Arabidopsis that make it successful as a model system, including small size (up to 1357 plants/m 2 ), short life cycle (70-90 days from sowing to fruit-ripening), relatively small genome (950 Mb) and transformability. In this article we review the current status of the genetic transformation, genome sequencing, functional genomics, reverse genetic tools and improvement of fruit nutrition and flavor quality in MicroTom/tomato, which provides a vision of a new plant model system for functional genomics and its application to economic trait development for crops.
A Bandpass ΔΣ DDFS-Driven 19GHz Frequency Synthesizer for FMCW Automotive Radar

A 19GHz frequency-modulated continuous-wave TX based on a bandpass ΔΣ DDFS-driven RF frequency synthesizer is presented. Implemented in a 0. 25μm SiGe process, the synthesizer draws 63mA from a 2.5V supply while achieving a 512MHz FM deviation with a 200Hz FM rate at a center frequency of 19GHz. The measured phase noise of the frequency synthesizer is -113.68dBc/Hz at 1MHz offset frequency from a 19GHz carrier
HLA-B Genotype in Japanese Patients With Crohn’s Disease

PURPOSE The HLA-B gene is one of the susceptibility genes for inflammatory bowel disease. Previous association studies of HLA-B showed several associated alleles and haplotypes of HLA-B in patients with ulcerative colitis, and among the associated alleles HLA-B*52 is well known to be strongly associated with ulcerative colitis in Japanese patients. However, there are no convincing reports about HLA-B including the B*52 allele in patients with Crohn’s disease. The purpose of this study was to determine if HLA-B, especially the B*52 allele, confers susceptibility to Crohn’s disease or determines the disease phenotype of Crohn’s disease. METHODS A total of 195 patients with Crohn’s disease (49 ileitis, 106 ileocolitis, 34 colitis, 6 uncertain) and 185 healthy controls were studied in this case-controlled study. All patients and healthy controls were Japanese. Genotyping of the HLA-B gene was performed by a polymerase chain reaction, sequence-specific primer that can classify the gene into 23 allele groups. Allele frequencies were compared between patients with Crohn’s disease and healthy controls with chi-squared test using a 2 × 2 contingency table. P value was corrected by the number of allele groups (n = 23) observed in the Japanese population or the number of clinical subgroups. Corrected P values of <0.05 were considered to be statistically significant. RESULTS Before the correction for multiple testing, B*4001 and B*44 were associated with patients with Crohn’s disease, positively and negatively, respectively. However, after the correction there were no significant differences in any HLA-B alleles between patients with Crohn’s disease and healthy controls. In the subgroup analysis according to clinical phenotypes (disease location, anal lesion, age at diagnosis, need for surgery), none of the HLA-B alleles except B*52 showed any disease phenotype-genotype associations. The allele frequency of B*52 in the colitis type (16.2 percent; corrected P = 0.011) was significantly higher than that in the combined group of the ileitis (7.1 percent) and ileocolitis (5.2 percent) types. CONCLUSIONS These results demonstrated that HLA-B did not confer overall susceptibility to Crohn’s disease in Japan, but the B*52 allele may affect the location of the disease.
Kinematic analysis of shear displacement as a means for operating mechanotransduction channels in the contact region between adjacent stereocilia of mammalian cochlear hair cells

In sensory hair cells of the cochlea, deflection of the stereociliary bundle results in direct mechanical gating of mechanoelectrical transduction channels, a function generally attributed to the tip link running between the tips of short stereocilia and the sides of adjacent taller ones. However, immunocytochemical experiments indicate that the channels may not be associated with the tip link but occur just below it in a region of contact between the stereocilia. To determine whether transduction channels in this location could be operated during physiologically appropriate deflections as effectively by shear displacement as if they were associated with the tip link, a two–dimensional kinematic analysis of relative motion between stereocilia has been performed assuming contact between stereocilia is maintained during deflection. Bundle geometry and dimensions were determined from transmission electron micrographs of hair cells from several frequency locations between 0.27 and 13.00 kHz in the guinea–pig cochlea. The analysis indicates that for a 10 nm deflection of the tallest stereocilia of both inner and outer hair cells, i.e. within the range of the maximum sensitivity of mammalian hair bundles, the average shear displacement in the contact region would be 1.6 nm, but that it increases systematically towards higher frequency regions for outer hair cells. This displacement is comparable in magnitude to tip–link elongation for individual stereociliary pairs.
Evidence for identity inhibition during selective attention in old adults.

Previous studies of negative priming have shown that, relative to young adults, old adults can effectively suppress location information associated with stimuli, but not information about the identity of stimuli. S.L. Connelly and L. Hasher (1993) attributed this dissociation to an age-related decrement in the inhibitory processes that suppress meaning-bearing information. In this study, the authors report both identity negative priming and distractor interference in a group of young and old adults. Their results force a reconsideration of an age-related decrement in the inhibitory processes underlying the suppression of meaning-bearing information. The results also suggest that whether a relationship between negative priming and interference is observed may depend on whether the 2 measures index the same level of processing.