Miracle-dz/UniFAR-FTUs huggingface dataset:
Disaster after the plaster. Fentanyl withdrawal symptoms in a curable hospice patient

Abstract Opioids have been used for thousands of years for pain relief. Transdermal fentanyl (TDF) is a synthetic opioid that is prescribed for the treatment of chronic pain. This clinical lesson demonstrates that TDF may be easy to start but sometimes difficult to stop. Like any other opioid there is a substantial risk of physical dependence and subsequent withdrawal symptoms after discontinuation of the drug. Here, we present a case of a hospice patient who developed withdrawal symptoms after a first TDF tapering attempt according to the manufacturer's instructions. A second, more gradual tapering regimen did not result in withdrawal symptoms. The mechanisms and treatment modalities for physical dependence along with a tailor-made tapering strategy that is suitable for general practice are presented in this clinical lesson.
Research on product information model for collaborative design

A three-layer structural product information model is put forward. The information interaction of each layer is researched. In data layer, model-driven mapping method is adopted. The bidirectional data mapping mechanism is set up between XML and database using JavaBean object as the middleware. In logic layer, the paper uses product structure tree to take organization and management on components and parts. And in user layer, the model is given the ability of real-time and synchronous information interaction using AJAX The collaborative design prototype system is developed based on AJAX4JSF. The product information model of GC 1–2 sewing machine is built using the approach put forward by the paper. The tests show that model's real-time and synchronous information interaction capacities are improved.
A Novel Nuclear Signaling Pathway for Thromboxane A2 Receptors in Oligodendrocytes: Evidence for Signaling Compartmentalization during Differentiation

ABSTRACT The present study investigated G protein expression, localization, and functional coupling to thromboxane A2 receptors (TPRs) during oligodendrocyte (OLG) development. It was found that as OLGs mature, the expression levels of Gq increase while those of G13 decrease. In contrast, the expression levels of Gs, Go, and Gi do not change significantly. Localization studies revealed that Gq, G13, and Gi are present only in the extranuclear compartment, whereas Gs and Go are found in both the extranuclear and the nuclear compartments. Purification of TPR-G protein complexes demonstrated that TPRs couple to both Gq and G13 in the extranuclear compartment but only to Gs in the nuclear compartment. Furthermore, functional analysis revealed that stimulation of nuclear TPR in OLGs stimulates CREB phosphorylation and myelin basic protein transcription and increases survival. Collectively, these results demonstrate that (i) OLGs selectively modulate the expression of certain G proteins during development, (ii) G proteins are differentially localized in OLGs leading to subcellular compartmentalization, (iii) TPRs couple to Gq and G13 in the extranuclear compartment and to Gs only in the nucleus, (iv) mature OLGs have a functional nuclear TPR-Gs signaling pathway, and (v) nuclear TPR signaling can stimulate CREB phosphorylation and myelin gene transcription and increase cell survival. These findings represent a novel paradigm for selective modulation of G protein-coupled receptor-G protein signaling during cell development.
Real time US-tagging combined with phase-based optical flow applied to 2D motion estimation of the carotid artery wall

Early detection of cardiovascular diseases (CVD) is possible by assessing the dynamic properties of the common carotid artery, i.e. the 2D (radial and longitudinal) motion of the wall layers. B-mode imaging is widely used, however this modality does not provide a high definition in the longitudinal direction (i.e. parallel to the probe) due to the aperture problem and the homogeneity of the tissues. To increase the definition in the longitudinal direction, we present here a specific beamforming method dedicated to estimate the 2D motion of the carotid artery wall. The generated US-tagged images present radiofrequency oscillations in both directions. The 2D motion is assessed with a specific phase-based optical flow method. The method was implemented in real time on a research echograph and applied in vivo on a healthy carotid over 3 cardiac cycles. The results show that our method is more accurate compared to classical block matching on B-mode images. Index Terms- Carotid Artery, US-Tagging, Phased-Based Optical Flow Matching, Motion Estimation, Block Matching, Real Time, Beamforming, RF2D.
Results of Cohen-Lenstra type for quadratic function fields

Consider hyperelliptic curves C of fixed genus over a finite field F. Let L be a finite abelian group of exponent dividng N . We give an asymptotic formula in |F|, with explicit error term, for the proportion of C for which Jac(C)[N ](F) ∼= L.
Clinical activity of azacitidine in patients who relapse after allogeneic stem cell transplantation for acute myeloid leukemia

Disease relapse is the most common cause of treatment failure after allogeneic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndromes, yet treatment options for such patients remain extremely limited. Azacitidine is an important new therapy in high-risk myelodysplastic syndromes and acute myeloid leukemia but its role in patients who relapse post allograft has not been defined. We studied the tolerability and activity of azacitidine in 181 patients who relapsed after an allograft for acute myeloid leukemia (n=116) or myelodysplastic syndromes (n=65). Sixty-nine patients received additional donor lymphocyte infusions. Forty-six of 157 (25%) assessable patients responded to azacitidine therapy: 24 (15%) achieved a complete remission and 22 a partial remission. Response rates were higher in patients transplanted in complete remission (P=0.04) and those transplanted for myelodysplastic syndromes (P=0.023). In patients who achieved a complete remission, the 2-year overall survival was 48% versus 12% for the whole population. Overall survival was determined by time to relapse post transplant more than six months (P=0.001) and percentage of blasts in the bone marrow at time of relapse (P=0.01). The concurrent administration of donor lymphocyte infusion did not improve either response rates or overall survival in patients treated with azacitidine. An azacitidine relapse prognostic score was developed which predicted 2-year overall survival ranging from 3%–37% (P=0.00001). We conclude that azacitidine represents an important new therapy in selected patients with acute myeloid leukemia/myelodysplastic syndromes who relapse after allogeneic stem cell transplantation. Prospective studies to confirm optimal treatment options in this challenging patient population are required.
Cortical control of vestibular-guided saccades in man.

Memory-guided saccades, made to a remembered location to which gaze was directed before a passive body rotation (i.e. with a vestibular input), were electro-oculographically recorded in 24 patients with various cortical lesions and in 18 control subjects. Anticipation and latency, direction errors and accuracy of the first saccade, stability of eye position in darkness and final eye position were quantified. Patients were divided into small groups, each with lesions affecting one of the following cortical areas: left or right frontal eye field (FEF), left or right prefrontal cortex (area 46 of Brodmann) (PFC), left supplementary eye field (SEF), left or right posterior parietal cortex (PPC) and right parieto-temporal cortex (PTC). There were some abnormalities in the results of the right FEF group, concerning anticipation, direction errors and latency of the first saccade, but no abnormality in the accuracy of the first saccade or of the final eye position. Results in the left FEF group were normal. Accuracy of the first saccade was impaired in the SEF group, bilaterally. Final eye position was also inaccurate in the SEF group. In both PFC groups, significant and, in general, bilateral abnormalities existed for all tested parameters. Accuracy of the first saccade was impaired in the PTC group, leftwards. In contrast, the results in both PPC groups were not significantly different from those of control subjects. Our results suggest that (i) the PFC is involved in the memorization of saccade goals probably encoded in spatiotopic coordinates; (ii) the SEF, but not the FEF, is involved in the control of accuracy of these vestibular-derived goal-directed saccades; (iii) the PTC (i.e. the vestibular cortex), but not the PPC, is involved in the control of such saccades. Therefore, a cortical network different from that involved in the control of memory-guided saccades made to visual targets, with only the PFC in common, could control vestibular-derived goal-directed saccades.
Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

Clostridial neurotoxins inhibit neurotransmitter release by selective and specific intracellular proteolysis of synaptobrevin/VAMP, synaptosomal‐associated protein of 25 kDa (SNAP‐25) or syntaxin. Here we show that in binary reactions synaptobrevin binds weakly to both SNAP‐25 and syntaxin, and SNAP‐25 binds to syntaxin. In the presence of all three components, a dramatic increase in the interaction strengths occurs and a stable sodium dodecyl sulfate‐resistant complex forms. Mapping of the interacting sequences reveals that complex formation correlates with the presence of predicted alpha‐helical structures, suggesting that membrane fusion involves intermolecular interactions via coiled‐coil structures. Most toxins only attack the free, and not the complexed, proteins, and proteolysis of the proteins by different clostridial neurotoxins has distinct inhibitory effects on the formation of synaptobrevin‐syntaxin‐SNAP‐25 complexes. Our data suggest that synaptobrevin, syntaxin and SNAP‐25 associate into a unique stable complex that functions in synaptic vesicle exocytosis.
Approximation for Dominating Set Problem with Measure Functions

In this paper, we study the Dominating Set problem with measure functions, which is extended from the general Dominating Set problem. We study the correspondnig problems on complexity, approximation and inapproximability for Dominating Set problem with measure functions. In addition, we extend our results to the weighted graphs.
Receptor-mediated tumor targeting with radiopeptides

Radiolabeled peptides have become important tools for preclinical cancer research, and in nuclear oncology they serve as diagnostic and more recently also as therapeutic agents. In the latter application, radiolabeled peptides represent a distinct sector of the molecular targeting approach, which in many areas of therapy implements the old “magic bullet” concept by specifically directing the therapeutic agent to the site of action. Although in the past few years the development of receptor-mediated targeting for therapy has been confined to some radiolabeled antibodies and to somatostatin/SRIF, research into an increasing number of radiolabeled peptides and their receptors expressed by different tumors will soon lead to a wider use of peptide radiopharmaceuticals. In a consecutive series of six reviews we present a comprehensive overview of the literature on receptor-mediated tumor targeting with the different radiopeptides currently studied. Part 1 summarizes the concepts and methods of radiopeptide targeting, the selection of radioisotopes, chelators, the critera of peptide ligand development and some general aspects of diagnostic and therapeutic application of peptide radiopharmaceuticals.
Fatal anaphylactic shock after aprotinin reexposure in cardiac surgery.

I n open heart surgery, the administration of aprotinin, a proteinase inhibitor extracted from bovine lung, may achieve a 30%-40% reduction in perioperative blood loss and transfusion requirement (l-3). In contrast to all other blood-saving techniques, the use of aprotinin represents a trespass into the patients’ immunologic memory. This is why in a recent communication we expressed concern about expanding its use in noncardiac procedures (4). We are now presenting the first report on an anaphylactic shock after aprotinin reexposure in open heart surgery where resuscitation was unsuccessful, even with the aid of cardiopulmonary bypass (CPB).
Long-term in vitro culture of murine mast cells. II. Purification of a mast cell growth factor and its dissociation from TCGF.

Procedures are described for the isolation of a mast cell growth factor (MCGF) from medium conditioned by mitogen-activated splenic leukocytes (CM). Although optimal conditions for the production of MCGF in CM are identical to those for the production of T cell growth factor (TCGF), MCGF can be dissociated from TCGF after the first stage of purification on a DEAE-cellulose column. MCGF elutes from the column in the breakthrough fraction, whereas TCGF binds avidly to DEAE and is eluted only at high salt concentration. MCGF also differs from TCGF with respect to m.w. (as estimated by Sephadex G-150 chromatography) and sensitivity to trypsin. In addition, MCGF is produced by the murine myelomonocytic leukemia WEHI-3 and the radiation induced thymic lymphoma LBRM-33 cells, whereas TCGF is produced only by the latter in the presence of a mitogen. Another hemopoietically active factor, granulocyte colony-stimulating factor (G-CSF) present in media conditioned by WEHI-3 and LBRM-33 cells, however, shares a number of properties with MCGF. Although studies with purified or partially purified MCGF have thus far failed to reveal a correlation between MCGF and G-CSF, further biochemical analyses are necessary to dissociate MCGF from G-CSF.
Glycemic, hormone, and appetite responses to monosaccharide ingestion in patients with type 2 diabetes.

To investigate the relative effects of fructose and glucose on blood glucose, plasma insulin and incretin (glucagon-like peptide-1 [GLP-1] and gastric inhibitory peptide [GIP]) concentrations, and acute food intake, 10 (6 men, 4 women) patients with diet-controlled type 2 diabetes (diabetic) (44 to 71 years) and 10 age and body mass index (BMI)-matched (6 men, 4 women) nondiabetic, control subjects with varying degrees of glucose tolerance (nondiabetic), were studied on 3 days. In random order, they drank equienergetic preloads of glucose (75 g) (GLUC), fructose (75 g) (FRUCT) or vehicle (300 mL water with noncaloric flavoring [VEH]) 3 hours before an ad libitum buffet lunch. Mean glucose concentrations were lower after FRUCT than GLUC in both type 2 diabetics (FRUCT v GLUC: 7.5 +/- 0.3 v 10.8 +/- 0.4 mmol/L, P <.001) and nondiabetics (FRUCT v GLUC: 5.9 +/- 0.2 v 7.2 +/- 0.3 mmol/L, P <.05). Mean insulin concentrations were approximately 50% higher after FRUCT in type 2 diabetics than in nondiabetics (diabetics v nondiabetics: 23.1 +/- 0.7 v 15.1 +/- 1.3 microU/mL; P <.0001). Plasma GLP-1 concentrations after fructose were not different between type 2 diabetics and nondiabetics (P >.05). Glucose, but not FRUC, increased GIP concentrations, which were not different between type 2 diabetics and nondiabetics (P >.05). Food intake was suppressed 14% by GLUC (P <.05 v CONT) and 14% by FRUC (P <.05 v CONT), with no difference between the amount of food consumed after GLUC and FRUC treatment in either type 2 diabetics or nondiabetics (P >.05). We have confirmed that oral fructose ingestion produces a lower postprandial blood glucose response than equienergetic glucose and demonstrated that (1) fructose produces greater increases in plasma insulin concentration in type 2 diabetics than nondiabetics, not apparently due to greater plasma incretin concentrations and (2) fructose and glucose have equivalent short-term satiating efficiency in both type 2 diabetics and nondiabetics. We conclude that on the basis of improved glycemic control, but not satiating efficiency, fructose may be useful as a replacement for glucose in the diet of obese patients with type 2 diabetes.
Engineering accreditation: A developing nation perspective

In many developing countries engineering education is young and characterized by two contradictory trends. On the one hand, strained finances may force available resources to fall below the levels required by world standards. On the other hand, many engineers are graduates of foreign universities and more graduates of local engineering schools are having their careers in industrial nations, be it for postgraduate studies or for employment. This results in many institutions trying to meet the global accreditation standards where possible at the expense of local considerations in engineering programs, an effort that may not extend to areas where the costs are substantial such as laboratory equipment and faculty load and training. Pressure mounts to increase class size and to replace real lab work by simulations, traditional instruction by virtual classes. This resulted in a situation where a large number of engineering programs meet the accreditation criteria only partially, a fact that complicates the task of accreditation bodies. They find it necessary to practice retrospective accreditation of engineering degrees from widely varying educational systems, without clear local standards to measure against. Outcomes based assessment is the exception and the focus is almost entirely on incomes and numbers. No major studies or exams are being performed to evaluate and compare the quality of graduates and to offer ranking of programs. On the example of export oriented engineering education in Palestine we elaborate on the efforts to adapt ABET style accreditation requirements and procedures to a developing nation context and the effects of such an approach on the quality of outcomes in terms of the suitability for the market place. We argue that proper accreditation can do much to encourage engineering schools to improve performance, consolidate programs and attract/retain qualified faculty and subsequently contribute to economic development in the country.
ANALYSIS OF THE CHANGES IN CHEMICAL PROPERTIES OF DISSOLVING PULP DURING THE BLEACHING PROCESS USING PIECEWISE LINEAR REGRESSION MODELS

Dissolving wood pulp is a chemically bleached wood pulp that has a cellulose content of more than 90%. Such pulp has certain properties of industrial value according to the products it can be used for. Raw pulp, which comes after acid bisulphite pulping, goes through a number of bleaching processing stages, each with a specific role, to produce dissolving pulp. These processing stages have different effects on the pulp depending on the type of wood genotype that is being processed. The bleaching processing stages are considered as time points for repeated measurements of the following chemical properties viz., viscosity, lignin, �-cellulose, �-cellulose, copper number, glucose and xylose. Piecewise regression models were used to compare the behaviour of the chemical properties of the seven genotypes throughout the bleaching processing stages. In order to cut costs on the chemicals used for processing, it is important to identify species/genotypes that have similar chemical properties under the chemical pulping process in order to mix them together for optimised processing. It was established that when trying to classify different timber species/genotypes for the purpose of finding which ones can be mixed together, viscosity is not an important variable to consider. The other variables viz., lignin, �-cellulose, �-cellulose, copper number, glucose and xylose should be used for classification as they were found to be important for that purpose. It is suggested that these properties can also be used in multivariate classification procedures.
Genome Sequence of Serinicoccus profundi, a Novel Actinomycete Isolated from Deep-Sea Sediment

ABSTRACT Serinicoccus profundi MCCC 1A05965T was isolated from deep-sea sediment collected from the Indian Ocean. It was a Gram-positive, moderately halophilic, aerobic bacterium. Here, we describe the 3.4-Mbp draft genome sequence of S. profundi MCCC 1A05965T.
EBV‐associated diffuse large B‐cell lymphoma arising in the chest wall with surgical mesh implant

In Japan, most cases of malignant lymphoma arising in the thorax are pyothorax‐associated lymphoma, which develops in patients who have undergone artificial pneumothorax, used in the past as surgical therapy for pulmonary tuberculosis. Pyothorax‐associated lymphoma consist mostly of diffuse large B‐cell lymphoma and have a strong association with EBV. Herein is reported the case of a diffuse large B‐cell lymphoma arising in the left thoracic wall after left lung resection for squamous cell carcinoma and chest wall reconstruction with polyethylene terephthalate (PET) surgical mesh. The tumor was found 20 years after the operation and was confined to the chest wall adjacent to the PET mesh. The patient did not have a clinical history of pyothorax after surgery. The lymphoma cells were of the large cell type and were positive for CD20, EBV‐encoded small RNA–in situ hybridization, LMP‐1 and EBNA‐2. The present case demonstrates that EBV‐related B‐cell lymphoma can occur after surgery other than artificial pneumothorax. In the present case, long‐standing chronic inflammation induced by PET mesh may have been associated with the development of lymphoma.
Automating specification-based software testing

From the Publisher: What is the fastest, cheapest way to get a software product to market? Don't test it! What is the fastest, cheapest way to get a reliable software product to market? Use automated specification-based testing as an integral part of software development. This book explains what specification-based testing is, why it is the best kind of testing, how it is performed, how it prevents defects, and how it is automated.
Prevalence of Astigmatism in Native American Infants and Children

Purpose. To describe the prevalence of high astigmatism in infants and young children who are members of a Native American tribe with a high prevalence of astigmatism. Methods. SureSight autorefraction measurements were obtained for 1461 Tohono O'odham children aged 6 months to 8 years. Results. The prevalence of astigmatism >2.00 diopters was 30% in Tohono O'odham children during infancy (6 months to <1 year of age) and was 23 to 29% at ages 2 to 7 years. However, prevalence dipped to 14% in children 1 to <2 years of age. At all ages, axis of astigmatism was with-the-rule (plus cylinder axis 90° ± 30°) in at least 94% of cases. Conclusions. As in non-Native American populations, Tohono O'odham infants show a high prevalence of astigmatism, which decreases in the second year of life. However, the prevalence of high astigmatism in Tohono O'odham children increases by age 2 to <3 years to a level near that seen in infancy and remains at that level until at least age 8 years. Longitudinal data are needed to determine whether the increase in high astigmatism after infancy occurs in infants who had astigmatism as infants or is due to the development of high astigmatism in children who did not show astigmatism during infancy.