Miracle-dz/UniFAR-FTUs huggingface dataset:
Diametral Tensile Strength Evaluation of Carbonate Apatite Cement Reinforced by Genipin Cross-Linked Gelatin

Carbonate apatite is one of the most widely studied bioceramic material for its use as bone cement. On the previous study, it has already stated that CO3Ap cement has good osteoconductivity which makes this cement could be replaced by bone. However, the mechanical strength of CO3Ap cement is still low. This low mechanical strength is estimated due to the high porosity and absence of organic components. The aim of this study is to improve the mechanical strength of the CO3Ap cement reinforced by gelatin as an organic component with genipin as a cross-linking agent (Gelapin). The powder phase of vaterite and DCPA at weight ratio 40:60 were mixed with 0.2 mol/L Na2HPO4, 5% (w/v) gelatin, and 20% (v/v) genipin using 0.5 liquid to powder (L/P) ratio. The liquid phase ratios of Na2HPO4 and Gelapin were 50:50, 70:30, and 90:10. For control group, Gelapin were didn’t mixed in the liquid. Diametral tensile strength was improving and statistically significant (p<0.05) on set cement with 50:50 liquid ratio, the average value was 6.02 ± 0.14 MPa whereas the average value of the control group was only 3.10 ± 0.15 MPa. For this instance, gelatin serves a polymer matrix so the carbonate apatite crystallites could be well distributed within it which then gives more flexibility and resistance for the cement. On the other hand, genipin was also successfully cross-linked the gelatin. This study showed that by reinforcing CO3Ap cement using genipin cross-linked gelatin might be a good candidate for a bone substitute material.
Low Voltage FGMOS Four Quadrants Analog Multiplier

In this paper a low voltage FGMOS analog multiplier is proposed that uses a follower voltage flipped (FVF), which dominates its operation. In order to reduce the power supply of the multiplier, floating gate CMOS transistors (FGMOS) are used. Theoretical steps of the FVF design are presented together with its simulation. The output of the FVF is insensitive to the device parameters and is loaded with a resistive load. The multiplier design consists of two FVF cells, two current sensors FVF and one Gilbert cell multiplier. The results show that the proposed multiplied in a 0. 13μm CMOS process exhibits significant benefits in terms of linearity, insensibility to device parameters, bandwidth and output impedance. The power supply is 0.8V and a power consumption of 181μW.
Nutritional Characteristics of Prepacked Feta PDO Cheese Products in Greece: Assessment of Dietary Intakes and Nutritional Profiles

Feta cheese, a protected designation of origin (PDO) food, is one of the most important Mediterranean food products. Although it is the cheese with the highest consumption in Greece, the nutritional characteristics of products available in the market, as well as their contribution to the Greek diet, have not been evaluated in detail. In the present study, the basic nutritional content of 81 prepacked feta cheese products available in the Greek market were recorded based on their labels. This was combined with consumption data to provide an overall picture of feta cheese’s contribution to the Greek diet. The nutrient contents per 100 g ranged as follows. Energy: 221–343 kcal, total fat: 20–29 g, saturated fat: 12.8–20.3 g, carbohydrates: 0–3.1 g, sugars: 0–3 g, proteins: 13.1–21.0 g and salt: 1.2–5.1 g. The median feta daily individual consumption was found to be 39 g, ranging from 20 g to 100 g (fifth and 95th percentiles, respectively). The nutritional intake analysis as a percentage of dietary reference intake (DRI) showed that saturated fat and salt are ranked on the top of the list, with intakes reaching 101.5% and 85% respectively. The products were also evaluated against five nutrient profile models and their potential use under statutory requirements and policy development are discussed.
Computing Semantic Roles Using ANN’s with External Memory

—Building on recent improvements in neural based Semantic Role Labeling (SRL) and on some recent improvements in neural architectures, in this paper we demonstrate a new memory network based model for SRL. Unlike previous neural architectures for the task of SRL, our model’s architecture has the addition of long term memory capabilities and recall. In order to do so we had to remove the bidirectional capabilities of our controller and weight the cost function of the model in order to make it small and sensitive enough to be trained at all. However despite the working model, due to some of the weaknesses of the kind of memory network that we used, the Differntiable Neural Computer (DNC), we are currently unable to demonstrate fully trained results.
Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

The potential pharmaceutical application of nanoparticles has led to the toxicity within the male reproductive system. In the present study, the effects of silver nanoparticles (Ag-NPs) on hematological parameters, free radical generation, antioxidant system, sperm parameters, and organ histo-morphometry in male rats were investigated. Ag-NPs were produced by the reduction of silver ions, while the formation of which was monitored by UV–visible spectrophotometry. Zeta potential, transmission, and scanning electron microscopies were applied for the characterization of AgNPs. A total of 30 rats were divided into 6 groups and were sub-dermally exposed to Ag-NPs at the dosage of 0 (control), 10, and 50 mg/kg bodyweight (bw) doses for either 7 or 28 days. Ag-NP administration altered hematological indices and caused dose-dependent decreases in sperm motility, velocity, kinematic parameters, concentrations of luteinizing hormone, follicle-stimulating hormone, and testosterone. In the epididymis and testis, the concentrations of malondialdehyde and peroxide increases while superoxide dismutase, catalase, reduced glutathione, and total thiol group decreases. These findings suggest that Ag-NP triggered hormonal imbalance and induce oxidative stress in testis and epididymis; which negatively affect sperm parameters of male rats.
Consideration of Future Consequences Influences Involvement in Romantic Partners’ Health

ABSTRACT This study examined the influence of people’s short-term (e.g., convenience) and long-term (e.g., maintain weight) motives toward their romantic partner’s health on their provision of health-related social control and autonomy support for their partner’s health behaviors, as well as their indifference toward their romantic partner’s health. Data from a sample of cohabiting couples (N = 212) were analyzed using multilevel path models. Results showed having more long-term motives for a partner’s health lead to increased provisions of autonomy support and social control, and less indifference toward the partner’s health, especially when the partner had lower long-term health motives themselves. In contrast, having more short-term motives for a partner’s health was associated with providing less social control and autonomy support and showing more indifference toward the partner’s health. Thus, people motivated to improve their partner’s long-term health engage in more behaviors meant to improve their romantic partner’s health choices, particularly when the partner has low motivation to regulate their own health behaviors.
The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2

During axonal ensheathment, noncompact myelin channels formed at lateral edges of the myelinating process become arranged into tight paranodal spirals that resemble loops when cut in cross section. These adhere to the axon, concentrating voltage‐dependent sodium channels at nodes of Ranvier and patterning the surrounding axon into distinct molecular domains. The signals responsible for forming and maintaining the complex structure of paranodal myelin are poorly understood. Here, we test the hypothesis that the planar cell polarity determinant Vangl2 organizes paranodal myelin. We show that Vangl2 is concentrated at paranodes and that, following conditional knockout of Vangl2 in oligodendrocytes, the paranodal spiral loosens, accompanied by disruption to the microtubule cytoskeleton and mislocalization of autotypic adhesion molecules between loops within the spiral. Adhesion of the spiral to the axon is unaffected. This results in disruptions to axonal patterning at nodes of Ranvier, paranodal axon diameter and conduction velocity. When taken together with our previous work showing that loss of the apico‐basal polarity protein Scribble has the opposite phenotype—loss of axonal adhesion but no effect on loop–loop autotypic adhesion—our results identify a novel mechanism by which polarity proteins control the shape of nodes of Ranvier and regulate conduction in the CNS.
Climate associated genetic variation in Fagus sylvatica and potential responses to climate change in the French Alps

Local adaptation patterns have been found in many plants and animals, highlighting the genetic heterogeneity of species along their range of distribution. In the next decades, global warming must induce a change in the selective pressures that drive this adaptive variation, forcing a reshuffling of the underlying adaptive allele distributions. For species with low dispersion capacity and long generation time such as trees, the rapidity of the change could imped the migration of beneficial alleles and lower their capacity to track the changing environment. Identifying the main selective pressures driving the adaptive genetic variation is thus necessary when investigating species capacity to respond to global warming. In this study, we investigate the adaptive landscape of Fagus sylvatica along a gradient of populations in the French Alps. Using a ddRAD-seq approach, we identified 7,000 SNPs from 570 individuals across 36 different sites. An RDA-derived method allowed us to identify several SNPs that were strongly associated with climatic gradients; moreover, we defined the primary selective gradients along the natural populations of F. sylvatica in the Alps. Strong effects of elevation and humidity, which contrast north-western and south-eastern site, were found and were believed to be important drivers of genetic adaptation. Finally, simulations of future genetic landscapes that used these findings predicted a severe range contraction and a shift towards higher altitudes for F. sylvatica in the Alps and allowed to identify populations at risk, which could be helpful for future management plans.
Can young skiers perform well both in sprint and endurance races?

The skiers participate in two races in Falu Winter Games which are held on Saturday and Sunday. The race on Saturday is an individual race while on Sunday it is a relay race (team sprint). The races are divided into different classes by age and gender. The individual race requires endurance whereas the team sprint requires strength and speed. This thesis is to determine whether the young skiers can perform well both in the endurance race (Saturday) and in the sprint race (Sunday). I will use linear model analysis and apply the method on data from the individual races and the team sprints collected in February 2008. I conclude that the relationship between young skiers’ performance in endurance and sprint races is not so strong and if they want to perform well in both races, they need more practice to improve some special abilities.
Neuroenhancing Substances Use, Exam Anxiety and Academic Performance in Bosnian-Herzegovinian First-Year University Students.

OBJECTIVE The aim of this study was to assess the relationship between the use of neuroenhancing substances, exam anxiety and academic performance among first-year Bosnian-Herzegovinian (BH) university students. METHODS In a cross-sectional study, an ad hoc questionnaire was delivered to a sample of BH first-year university students. The following data were collected: socio-demographic features, consumption of neuroenchancing substances, the Westside Test Anxiety Scale (WTAS) and academic performance. RESULTS A total of 214 students were included. Consumption of lifestyle substances, coffee, energy drinks, nicotine, alcohol, and marijuana, for the purpose of neuroenhancement increased during the week before the exams. OTC cognitive enhancer use was reported by 31.0%, and of benzodiazepines by 1.5% of students. No psycostimulants were used. A high to extremely high exam WTAS score was reported in 38.3% students. The exam WTAS score was positively correlated with consumption of coffee (rho=0.31; P<0.001), energy drinks (rho=0.18; P=0.009), and nicotine (rho=0.22; P=0.001), and negatively correlated with last exam grade (rho=-0.33; P<0.001). The exam WTAS score was a significant independent predictor (OR=0.55; 95% CI 0.31 to 0.97, P=0.039) for self-assessed academic performance. Self-assessed academic performance was positively correlated with last exam grade (rho=0.15; P=0.043). CONCLUSIONS Although first-year BH university students do not seem to use either prescription or illicit psycostimulants, the consumption of nicotine, alcohol, and marijuana is worrying. However, the consumption of these neuroenhancing substances seems not to be related to better self-assessed academic performance. Finally, exam anxiety seems to be a significant problem among BH first-year university students.
Loss of life expectancy from air pollution compared to other risk factors: a worldwide perspective

Abstract Aims Long-term exposure of humans to air pollution enhances the risk of cardiovascular and respiratory diseases. A novel Global Exposure Mortality Model (GEMM) has been derived from many cohort studies, providing much-improved coverage of the exposure to fine particulate matter (PM2.5). We applied the GEMM to assess excess mortality attributable to ambient air pollution on a global scale and compare to other risk factors. Methods and results We used a data-informed atmospheric model to calculate worldwide exposure to PM2.5 and ozone pollution, which was combined with the GEMM to estimate disease-specific excess mortality and loss of life expectancy (LLE) in 2015. Using this model, we investigated the effects of different pollution sources, distinguishing between natural (wildfires, aeolian dust) and anthropogenic emissions, including fossil fuel use. Global excess mortality from all ambient air pollution is estimated at 8.8 (7.11–10.41) million/year, with an LLE of 2.9 (2.3–3.5) years, being a factor of two higher than earlier estimates, and exceeding that of tobacco smoking. The global mean mortality rate of about 120 per 100 000 people/year is much exceeded in East Asia (196 per 100 000/year) and Europe (133 per 100 000/year). Without fossil fuel emissions, the global mean life expectancy would increase by 1.1 (0.9–1.2) years and 1.7 (1.4–2.0) years by removing all potentially controllable anthropogenic emissions. Because aeolian dust and wildfire emission control is impracticable, significant LLE is unavoidable. Conclusion Ambient air pollution is one of the main global health risks, causing significant excess mortality and LLE, especially through cardiovascular diseases. It causes an LLE that rivals that of tobacco smoking. The global mean LLE from air pollution strongly exceeds that by violence (all forms together), i.e. by an order of magnitude (LLE being 2.9 and 0.3 years, respectively).
Study on Absorption Mechanism and Tissue Distribution of Fucoidan

Fucoidan exhibits several pharmacological activities and is characterized by high safety and the absence of toxic side effects. However, the absorption of fucoidan is not well-characterized. In the present study, fucoidan were labeled with fluorescein isothiocyanate (FITC) and their ability to traverse a monolayer of Caco-2 cells was examined. The apparent permeability coefficients (Papp × 10−6) of FITC-labeled fucoidan (FITC-fucoidan) were 26.23, 20.15, 17.93, 16.11 cm/sec, respectively, at the concentration of 10 μg/mL at 0.5, 1, 1.5 and 2 h. The absorption of FITC-fucoidan was suppressed by inhibitors of clathrin-mediated endocytosis, chlorpromazine, NH4Cl, and Dynasore; the inhibition rates were 84.24%, 74.61%, and 63.94%, respectively. This finding suggested that clathrin-mediated endocytosis was involved in fucoidan transport. Finally, tissue distribution of FITC-fucoidan was studied in vivo after injection of 50 mg/kg body weight into the tail vein of mice. The results showed that FITC-fucoidan targeted kidney and liver, reaching concentrations of 1092.31 and 284.27 μg/g respectively after 0.5 h. In summary, the present work identified the mechanism of absorption of fucoidan and documented its tissue distribution, providing a theoretical basis for the future development of fucoidan applications.
Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of Polyscias filicifolia Shoots Cultivated In Vitro

Traditional medicinal plants are an important source of active compounds with potential antimutagenic activity. Polyscias filicifolia Bailey (Araliaceae) is a South Asian traditional herb used as an adaptogenic and cardiac drug. Extracts of P. filicifolia contain a wide range of biologically active compounds like phenolic acids and triterpenoid saponins. In the present study. antigenotoxic potential of three naturally occurring phenolic acids and extracts of P. filicifolia growing in vitro with the addition of elicitors was evaluated against direct (4-nitroquinoline-N-oxide (4NQO) and mitomycin C (MMC)) and indirect mutagens (2-aminoanthracene (2AA)). The evaluation was made using a bacterial umu-test. Moreover, the ability to prevent photogenotoxicity induced by chlorpromazine (CPZ) under UVA irradiation was measured. The phytochemical profiling of examined extracts revealed the presence of numerous compounds with the prevelance of chlorogenic, caffeic, and ferulic acid derivatives; however, saponin fractions were also determined. The antioxidant potential of extracts strictly correlated with their composition. The tested extracts exhibited high antigenotoxic activity if the assay was performed with 2AA and metabolic activation. Moreover, the extracts slightly decreased the MMC-induced genotoxicity. However, an increase of the genotoxic effect was observed in the assay performed with 4NQO. In addition, photo-antigenotoxic activity was observed. In our study, phenolic acids exhibited lower activity than the extracts.
Association between Physician-Diagnosed Asthma and Weight Status among Chinese Children: The Roles of Lifestyle Factors

Childhood asthma and obesity have posed a parallel epidemic over the past few decades. However, whether asthma diagnosis is associated with obesity, and what the roles of lifestyle factors play in this relationship, remained unclarified. This study aimed to investigate the association between asthma and weight status in Chinese children and explore the potential mediating and/or modifying roles of lifestyle factors in the association. In this cross-sectional study, 16,837 children aged 6–12 years were recruited from Guangzhou, China. Participants’ information on physician-diagnosed asthma was collected from parents, and data on physical activity, screen time, and sleeping were reported in a validated questionnaire. Height and weight were objectively measured, and weight status was classified by body mass index (BMI). Multiple logistic regression analysis and mediation analysis were used. Results showed that asthmatic children were at significantly higher risk of obesity (odds ratio (OR) 1.51, 95% confidence interval (CI) 1.03, 2.21) compared with non-asthmatic children. More importantly, this increased risk was even greater in children with moderate-to-vigorous physical activity <60 min/d and children with screen time >2 h/d (both Pinteraction < 0.05). Also, a positive relationship of asthma with overweight was found in children with screen time >2 h/d (OR 3.92, 95% CI 1.56, 9.88), while a negative association was observed between asthma and underweight in children aged 9–12 years (OR 0.23, 95% CI 0.06, 0.92). Mediation analysis indicated that these associations were not mediated by physical activity, screen time, or sleeping. The findings suggested that physician-diagnosed asthma was associated with higher risks of overweight and obesity, and these risks might be exacerbated by insufficient physical activity and prolonged screen time.
Stent with radioactive seeds strand insertion for malignant hilar biliary obstruction

Abstract Purpose This study aimed to assess clinical efficacy and long-term patient outcomes in individuals with malignant hilar biliary obstruction (MHBO) that had been treated via insertion of a stent with a radioactive seed strand (RSS). Material and methods A total of 84 MHBO patients were treated via either normal stent insertion (n = 48) or stent with RSS insertion (n = 36) from January 2015 to December 2018. Results The technical success rates of normal stent insertion and stent with RSS insertion were 93.8% (45/48) and 97.2% (35/36), respectively (p = .632), with clinical success rates of 93.3% (42/45) and 100% (35/35), respectively (p = .252). In these two patient groups, 11 and seven patients, respectively, suffered from stent dysfunction (p = .637). In the normal and RSS groups, median stent patency was 165 and 225 days, respectively (p < .001). All patients in the present study died due to tumor progression, with median survival times of 188 and 250 days in the normal and RSS stent groups, respectively (p < .001). Conclusion Relative to normal stent insertion, combined stent with RSS insertion can effectively prolong both stent patency and patient survival in patients with MHBO.
Productive Performance and Egg and Meat Quality of Two Indigenous Poultry Breeds in Vietnam, Ho and Dong Tao, Fed on Commercial Feed

Simple Summary Indigenous chicken breeds adapt well to the local conditions and provide the genetic diversity required to improve the development of poultry breeds. Nowadays, the intensive systems of chicken production use only hybrid lines with high genetic potential. These lines are a serious threat to the conservation of indigenous chicken breeds in the world. Therefore, research on indigenous chicken breeds are necessary in elucidating conservation and sustainable development strategies with respect to these chicken breeds. This work evaluates the production and laying performances, and the meat and egg quality of two breeds of Vietnamese broiler chickens, Ho and Dong Tao. Our work shows that the production performances of the two breeds are low compared to commercial lines. Improving the production and reproduction performances of these animals is necessary in contributing to the program of conservation and sustainable exploitation of these two emblematic breeds. Abstract The objective of this work was the evaluation of the meat production and laying performances, and the meat and egg quality of two breeds of Vietnamese broiler chickens, Ho and Dong Tao, fed on a commercial diet. In a survey, we continuously recorded for 28 weeks, the data on the production performance and meat quality of 250 chicks from each breed. We investigated egg laying and egg quality using 36 Ho and 32 Dong Tao hens during 52 weeks of laying. The growth patterns were similar for the two breeds. Feed conversion ratios were also similar, and demonstrated the low efficiency of these two breeds when compared to commercial broilers. Slaughter age proved to affect several carcass yield characteristics, showing that slaughtering between 16 and 20 weeks might be better than at the usual age of 28 weeks. Yield, carcass composition and meat quality differed between the two studied breeds. The eggs production and number of embryonated eggs were low for the two breeds when compared to other breeds, with a lower hatching performance in Ho than in Dong Tao. In summary, the production performances of Ho and Dong Tao chickens were low, even when birds were fed a commercial diet. The study demonstrates the need to find ways to improve the production and reproduction performances of these animals, in order to contribute to the program of conservation and exploitation of these two breeds.