Miracle-dz/UniFAR-FTUs huggingface dataset:
Studies on the ciliary epithelium and the zonule. II. Electron and fluorescence microscope observations on the function of membrane elaborations.

The two layers of cells forming the epithelium of the processes of the ciliary body are characterized by extensive elaborations of their membranes. The elaboration of the membranes of the cell layer facing the posterior chamber is of two types: ( a ) infoldings of the free surface facing the Posterior chamber and ( b ) interdigitations of the margins between adjacent cells (Pappas and Smelser 1 and Holmberg 2 ). Similar elaborations of cell membranes have been found in cells of other tissues engaged in secretion (Pease 3 ). It was reported previously that the experimental alteration of normal aqueous humor secretion by various agents produces changes in the fine structure of the cells. The most obvious changes noted were an increase in the number of vesicles in the cytoplasm and the concomitant disappearance of the infoldings and interdigitations. 1 Thus the loss of the infoldings and interdigitations of the ciliary epithelial cells is a
Lithium the magic ion: Restoring and preventing?

Australian & New Zealand Journal of Psychiatry, 48(9) and almost certainly does not have the financial firepower to hire the best professional lobbyists. Without greater independent financial clout, it is likely always to be standing in a queue behind the miners, banks and large corporations. The third means of persuasion, pathos, is undoubtedly the strongest, but also the most complex and unpredictable, and hence inherently risky. It refers to an immediate, palpable call to emotions and sympathies, including prejudices, and is particularly powerful when appealing to the identity and self-interest of the listener. The risks are illustrated, for example, in arguments to influence current Australian asylum-seeker policy that put forward a powerfully compassionate, humanitarian point of view; these have been easily countered by more powerful appeals to xenophobia. The result has been a hardening of political support for a morally untenable and logically contradictory policy of punishing victims of crime in order to deter the perpetrators of crime. Allison et al. (2014) take up this element of persuasion when they refer to ‘personal relationships’ and politicians being open to persuasion when they have ‘direct experience with a condition and understand(s) the impact’. As above, this can be a double-edged rhetorical sword, since some personal experiences may turn an individual towards a negative, stereotyped view of mental illness, leaving the person impervious to an alternative view. So, whoever seeks to advocate for continuing mental health reform needs to recognize both the strength and the risks of the third element of persuasion, and carefully weigh up the potential costs and benefits of using it. A final consideration in mental health advocacy is to be aware of the political-economic context into which this country, along with most others, is moving. This is the age of big capital. The striking inequities in the 2014 Australian Federal Budget signal that the ‘age of entitlement’ may indeed be over for the sick, disabled, poor and disadvantaged, but not for big banks, mining companies, large corporations and rentiers. As the distributions of income and wealth become more inequitable with time, we can look forward to a growing underclass of poor among which the burden of mental illness will inevitably grow. We will all pay a heavy price for this in the long term. Mental health advocacy may need to take a broader political and economic view than it has up to the present, and highlight the adverse mental health consequences of certain political and economic policies. For example, if we see a growing marketization of public health care, education, research and human services provision, with parallel curtailments of government spending in these areas, then the most vulnerable, the mentally ill, will likely suffer the most. Mental health advocacy will fail its constituency if it does not successfully adapt to or counter trends of this kind.
The pathogenesis of atherosclerosis--an update.

CARDIOVASCULAR disease remains the chief cause of death in the United States and Western Europe, and atherosclerosis, the principal cause of myocardial and cerebral infarction, accounts for the majority of these deaths.1 This review, like its predecessor,2 will not attempt to cover all literature on atherosclerosis. In a previous review of the pathogenesis of atherosclerosis,2 Glomset and I discussed various hypotheses of atherogenesis2 3 4 5 6 7 and emphasized the importance of intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of atherosclerosis. The response-to-injury hypothesis of atherogenesis2 3 4 5 6 proposes that "injury" to the endothelium is the initiating event in .
Neuroimagining … literally?

This issue of Acta Neuropsychiatrica has chosen a neuroimaging theme. The journal has returned to this topic after four years, having devoted an entire issue to imaging research in 2006. The need for an update is reflected in part by the many journals that are devoted solely to aspects of neuroimaging. It is an important field and one that is likely to continue to gain prominence in the coming decade. A comprehensive clinical overview article published two years ago in our sister journal Acta Psychiatrica Scandinavica detailed the emergence of newer technology and the ongoing improvements in analysis methodology that drive the development of new modalities and the conception of new insights in this field (1). Neuroimaging is in essence an evolving science and one that has truly captured the imagination of neuropsychiatry researchers. Hence, in this issue, in addition to the original articles that focus on various aspects of neuroimaging, we have published a review by Chisea at al (2) that examines the functional neural correlates of mindfulness meditations. This erudite review interrogates the extant data to determine whether there is a link between the mechanisms that underpin psychotherapeutic, pharmacological and placebo effects. The subsequent original articles embrace collectively a number of modalities that include structural, functional and multimodal imaging. Specifically, Sui et al (3) describe their findings from a study of grey matter changes in rape victims with PTSD using voxel-based morphometry. Calhoun et al (4) report their findings from an investigation into aberrant processing in schizophrenia using a fusion of functional MRI and EEG, and finally, Mortensen et al (5) report on an experiment that probes impulsivity in borderline disorder. In addition to these excellent articles, our regular sections – in particular Brain Bytes and Pics & Prose – provide succinct insights into the evolution of neuropsychiatric neuroimaging and the potential application of neuroimaging to the exploration of cerebral metabolic pathways. As technological advancement accelerates unabated it is conceivable that one day we will perhaps be in a position to capture our imagination using neuroimaging, ‘literally’.
Action Research for the Health and Safety of Domestic Workers in Montreal: Using Numbers to Tell Stories and Effect Change

In 2007, a Filipina organization in Quebec (PINAY) sought the help of university researchers to document the workplace health and safety experiences of domestic workers. Together, they surveyed 150 domestic workers and produced a report that generated interest from community groups, policymakers, and the media. In this article, we—the university researchers—offer a case study of community-university action research. We share the story of how one project contributed to academic knowledge of domestic workers' health and safety experiences and also to a related policy campaign. We describe how Quebec workers' compensation legislation excludes domestic workers, and we analyze the occupational health literature related to domestic work. Striking data related to workplace accidents and illnesses emerged from the survey, and interesting lessons were learned about how occupational health questions should be posed. We conclude with a description of the successful policy advocacy that was possible as an outcome of this project.
Are Naturalized Voters Driving the California Latino Electorate? Measuring the Effect of IRCA Citizens on Latino Voting

The 1990s witnessed the growth and maturation of the Latino electorate in California and many scholars have posited as to the reasons. One argument is that naturalizations by way of the Immigration Reform and Control Act (IRCA) drove the increases in Latino participation. In this article we investigate the extent to which this is the case. Copyright (c) 2005 by the Southwestern Social Science Association.
The greater Agulhas Current system: An integrated study of its mesoscale variability

For the purpose of developing an operational oceanography system for the greater Agulhas Current regime, a high resolution Hybrid Coordinate Ocean Model (HYCOM) has been set in a nested configuration. The intense and complex current regime poses a challenge in modelling. However, access to satellite and in-situ data with strong and persistent signals of the dynamics and mesoscale variability ensure that adequate model validation is feasible. The study concludes that HYCOM reproduces the general larger scale circulation of the greater Agulhas Current reasonably accurately in addition to the regionally specific characteristics and mesoscale variability. Furthermore, strong anticyclonic eddies occurring in the Mozambique Channel at a frequency of 5–6 per year, are found to drift southward and merge with the northern Agulhas Current. Evidence of these eddies can also be tracked further southwestwards into the southern Agulhas Current and sometimes all the way towards the Agulhas retroflection region. Operational forecasting of the greater Agulhas Current, and in particular the retroflection, must therefore adequately account for the presence and influence of the Mozambique Channel eddies, in order to forecast their evolution on time scales from days to weeks
Restoration of Self-awareness of Hypoglycemia in AdultsWith Long-standing Type 1 Diabetes Hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial

OBJECTIVEdImpaired awareness of hypoglycemia (IAH) and defective counterregulation significantly increase severe hypoglycemia risk in type 1 diabetes (T1D). We evaluated restoration of IAH/defective counterregulation by a treatment strategy targeted at hypoglycemia avoidance in adults with T1D with IAH (Gold score $4) participating in the U.K.-based multicenter HypoCOMPaSS randomized controlled trial.
Structural enzymology comparisons of multifunctional enzyme, type‐1 (MFE1): the flexibility of its dehydrogenase part

Multifunctional enzyme, type‐1 (MFE1) is a monomeric enzyme with a 2E‐enoyl‐CoA hydratase and a 3S‐hydroxyacyl‐CoA dehydrogenase (HAD) active site. Enzyme kinetic data of rat peroxisomal MFE1 show that the catalytic efficiencies for converting the short‐chain substrate 2E‐butenoyl‐CoA into acetoacetyl‐CoA are much lower when compared with those of the homologous monofunctional enzymes. The mode of binding of acetoacetyl‐CoA (to the hydratase active site) and the very similar mode of binding of NAD+ and NADH (to the HAD part) are described and compared with those of their monofunctional counterparts. Structural comparisons suggest that the conformational flexibility of the HAD and hydratase parts of MFE1 are correlated. The possible importance of the conformational flexibility of MFE1 for its biocatalytic properties is discussed.
Promesses et contraintes de la joaillerie numérique interactive: un aperçu de l'état de l'art

The miniaturization of electronic components paves the way for new interaction techniques for wearable computing. We briefly review interactive digital jewelry, an emerging subfield. We report the data of a limited poll about the way people perceive the prospect of digital jewelry. We then consider the constraints and the promise of digital jewelry, and finally classify the current solutions, which generally resort to gestural interaction.
A Semantic DOM Approach for Webpage Information Extraction

With the development of electronic technology and e-commerce, technology for web pages has attracted a lot of research efforts which becomes one of the hottest topics recently. This paper has proposed a semantic DOM(SDOM) approach for information extraction of e-commerce WebPages. With the combination of content and structure information, the precision and recall can achieve a good result which is shown in our experiments on listpage and tablepage data sets.
1 Graph Matching Using a Direct Classi�cation of Node Attendance �

An algorithm has been developed that �nds isomorphisms between both graphs and subgraphs. The development is introduced in the object recognition problem domain. The method isolates matching subgraphs, �nds a node-to-node mapping and reorders nodes thus permitting a direct comparison to be made between the resultant graphs. The algorithm is of polynomial order. It yields approximate results, maintaining a performance level for subgraph isomorphisms at or above 95% under a wide variety of conditions and with varying levels of noise. The performance on the full size comparisons associated w i t h g r aph isomorphisms has been found to be 100/100, also under a variety of conditions. Performance metrics, methods of testing and results are p r esented.
Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion

The influenza surface glycoprotein hemagglutinin (HA) is a potential target for antiviral drugs because of its key roles in the initial stages of infection: receptor binding and the fusion of virus and cell membranes. The structure of HA in complex with a known inhibitor of membrane fusion and virus infectivity, tert-butyl hydroquinone (TBHQ), shows that the inhibitor binds in a hydrophobic pocket formed at an interface between HA monomers. Occupation of this site by TBHQ stabilizes the neutral pH structure through intersubunit and intrasubunit interactions that presumably inhibit the conformational rearrangements required for membrane fusion. The nature of the binding site suggests routes for the chemical modification of TBHQ that could lead to the development of more potent inhibitors of membrane fusion and potential anti-influenza drugs.
Maturity Model Concepts for Sustainable Manufacturing

Sustainability has been identified as an emerging business megatrend that companies across the spectrum need to respond to. Companies in the manufacturing industry have also increased their efforts in this direction. However, the efforts for improving the efficiency of manufacturing processes vary widely across the industry and may vary even within different locations of a large manufacturing organization. This paper reviews major initiatives and research relevant to developing and providing guidance for organizations interested in sustainable manufacturing. A concept is proposed for a maturity model to assist manufacturers with understanding the status of their efforts for sustainable manufacturing specifically focusing on materials, energy, and water use. The concept is being presented to gather inputs from relevant stakeholders and for further development into a model that provides high-level guidance to manufacturers for improving sustainability of their operations.
An apodized surface grating coupler enabling the fabrication of silicon photonic nanowire sensor circuits in one lithography step

We present the design, fabrication, and experimental characterization of a silicon surface grating coupler that enables the creation of complete photonic nanowire sensor circuits in a single lithography step on a standard SOI wafer. This advance is achieved without sacrifices in the coupling efficiency through the use of an apodization algorithm that tunes the width of each gap and bar in the grating. This design optimization provides a high light coupling efficiency and a low back reflection with a grating etched fully through the SOI device layer. We experimentally demonstrate a coupling efficiency of 35% on a standard SOI substrate at a wavelength of 1536 nm, and show that with an optimized buried oxide (BOX) thickness, a coupling efficiency of 72% could be achieved.
Abstract PD2-04: Baseline circulatingESR1mutation analysis in the randomised phase III EFECT study of fulvestrant versus exemestane in advanced hormone receptor positive breast cancer

Background. ESR1 mutations are acquired frequently in hormone receptor positive breast cancer after treatment with aromatase inhibitors (AI) in the metastatic setting. In prior analysis of the SoFEA phase III randomised trial, we demonstrated the detection of ESR1 mutations in circulating tumor DNA (ctDNA) predicted for greater benefit of fulvestrant compared to exemestane (Fribbens et al JCO 2016). Methods. The phase III EFECT study randomised 693 patients with ER+ metastatic breast cancer who had progressed on a prior non-steroidal AI, between fulvestrant loading dose and then 250mg q28 days and exemestane (Chia S, et al. J Clin Oncol 2008). Baseline serum samples were available from 227 patients in EFECT, and were analysed for the 8 most common ESR1 mutations by multiplex digital PCR. The association between baseline ESR1 status and time to progression (TTP) was analysed using Kaplan-Meier methods. Results.ESR1 mutations were successfully analysed in 98% (222/227) of patients with baseline serum samples, with ESR1 mutations detected in 23.4% (52/222) samples. Overall, detection of ESR1 mutations at baseline was associated with shorter TTP (hazard ratio [HR] 2.03, 95% CI 1.26-3.29, p=0.004). In patients with ESR1 mutation detected, TTP was 2.0 months (95%CI, 1.7-2.4) on exemestane and 3.5 months (95%CI, 1.9-5.0) on fulvestrant (HR 0.67, 95%CI 0.37-1.19, p=0.17). In patients without ESR1 mutations detected, TTP was 4.5 months (95%CI, 3.7-5.6) on exemestane and 3.7 months (95%CI, 3.3-5.2) on fulvestrant (HR 1.05, 95%CI 0.75-1.45, p=0.78). A meta-analysis of SoFEA and EFECT will be presented at the conference. Conclusions. Historical serum samples may be used for ctDNA analysis, illustrating the potential for future research of sample archives. Patients with ESR1 mutation detected in ctDNA have poor outcome when treated with exemestane, replicating prior results from SoFEA and demonstrating clinical utility for ESR1 mutation ctDNA analysis. Citation Format: Turner N, Swift C, Kilburn L, Garcia-Murillas I, Johnston S, Budzar A, Robertson J, Gradishar W, Piccart M, Schiavon G, Chia S. Baseline circulating ESR1 mutation analysis in the randomised phase III EFECT study of fulvestrant versus exemestane in advanced hormone receptor positive breast cancer [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr PD2-04.
The prevalence of chronic widespread pain in the general population.

OBJECTIVE To establish the prevalence of chronic widespread pain and associated symptoms in a general population sample. METHODS Cross sectional postal survey of 2,034 adults in the north of England. RESULTS The point prevalence of chronic widespread pain was 11.2%. The symptom was strongly associated with other somatic complaints and with measures of depression and anxiety. CONCLUSION In the general population, this cardinal symptom of fibromyalgia is common and identifies a group who are more likely also to report symptoms of fatigue and depression.
Laboratory Diagnosis of Acquired Hemophilia A: Limitations, Consequences, and Challenges

Abstract Acquired hemophilia A (AHA) should be suspected in patients with a new onset of bleeding and an isolated prolongation of activated partial thromboplastin time. About 10% of patients do not bleed at the time of diagnosis, but are at risk of future bleeding, particularly during interventions or surgery. Diagnosis of AHA is confirmed by demonstrating markedly reduced factor VIII activity (FVIII:C) and neutralizing anti-FVIII antibodies, so-called inhibitors. Several limitations and pitfalls exist with the assays used to diagnose AHA. Interference can result from anticoagulants or lupus anticoagulant. The Bethesda assay used to measure inhibitor potency assumes a log–linear relationship between inhibitor concentration and effect on residual FVIII:C activity to allow exact quantification. However, this relationship is not present for the type 2 inhibitors typically seen in AHA. Therefore, this assay only provides a rough estimate of inhibitor potency. These limitations can explain, in part, why laboratory data, such as inhibitor potency, failed to predict bleeding or response to treatment in AHA. This article reviews the diagnostic approach to AHA, discusses assay-specific limitations and addresses some of the challenges for future research.
An algebraic approach to collision-avoidance trajectory planning for dual-robot systems: Formulation and optimization

SUMMARY Collision-Avoidance is a key issue in planning trajectories for dual robots whose workspaces overlap. In this paper, we develop a new trajectory planning method by proposing a traffic control schemes. The traffic controller determines the next positions for each robot based on the motion priority and path direction subject to the collision-avoidance conditions and the robots' physical limits. The problem of determining the next positions is formulated and optimized. Algebraic expressions for collision avoidance between every-pair of links – one from the first robot and the other from the second robot – are derived in configuration space. These algebraic expressions are then used to solve the problem of determining “optimal” (in the sense of path direction and motion priority) robots' trajectories. A solution procedure is developed using a nonlinear programming (NLP) solver. The main advantage of our approach is that the two robots' trajectories can be determined simultaneously without requiring any a priori path information. Several numerical examples are presented to demonstrate the validity and effectiveness of the proposed approach.
Customer satisfaction with Internet banking web sites : an empirical test and validation of a measuring instrument

Measuring user satisfaction with information systems has attracted widespread research attention, given it is often used as an indicator of success. The Internet has allowed applications to be extended to customers of an organization, where interaction can take place through a web site, typically from home or office. The focus of attention with such applications is customer satisfaction. In this research, a 21-item, 7-factor instrument developed to measure customer satisfaction with web sites that market generic digital products and services was modified slightly, and then empirically tested and validated in the context of Internet banking specifically. A 19-item, 5-factor validated instrument emerged, the factors being Customer Support, Security, Ease of Use, Transactions and Payment, and Information Content and Innovation. The difference in number of factors as compared to the generic instrument was attributed to the unique nature of Internet banking web sites. These and other findings are discussed in the paper, and their implications examined.
Marine Omega-3 Phospholipids: Metabolism and Biological Activities

The biological activities of omega-3 fatty acids (n-3 FAs) have been under extensive study for several decades. However, not much attention has been paid to differences of dietary forms, such as triglycerides (TGs) versus ethyl esters or phospholipids (PLs). New innovative marine raw materials, like krill and fish by-products, present n-3 FAs mainly in the PL form. With their increasing availability, new evidence has emerged on n-3 PL biological activities and differences to n-3 TGs. In this review, we describe the recently discovered nutritional properties of n-3 PLs on different parameters of metabolic syndrome and highlight their different metabolic bioavailability in comparison to other dietary forms of n-3 FAs.