Miracle-dz/UniFAR-FTUs huggingface dataset:
How metaphorical door handle influence users' opening-door behaviors

In this study, we clarify how a metaphorical door handle influence users' opening-door behaviors and what kansei value metaphorical door handle brings. To achieve this, we conducted a questionnaire with 12 door handles (made by 3D max) based on a sample of 200 students from Future University Hakodate. Each feature was evaluated on a scale from −2 to 2 according to 5 evaluation items. The data was computed as average scores, then visual information and principle component analysis were conducted for an integrated survey. As a results, we clarify that door handle with metaphorical design can influence users' opening-door behaviors. Otherwise, we found out a door handle with an appropriate metaphor expression is original and suitable to use.
Acceleration of lipid degradation by sericoside of Terminalia sericea roots in Fully differentiated 3T3‐L1 cells

Sericoside is a traditional herbal saponin from Terminalia sericea (Family Combretaceae). The influence of sericoside on lipolysis was studied in fully differentiated 3T3‐L1 cells, and glycerol release into the cytosol and residual triglyceride were measured. The addition of sericoside stimulated glycerol release into the cytosol from deposited triglyceride in a dose‐ and time‐dependent manner. These data suggested that sericoside has a strong lipolytic activity. Copyright © 2006 John Wiley & Sons, Ltd.
The Psychology of Contract Precautions

This research tests the intuition that parties to a contract approach each other differently before the contract is formed than they do once it is finalized. We argue that one of the most important determinants of self-protective behavior is whether the promisee considers herself to be in negotiations or already in an ongoing contract relationship. That shift affects precaution-taking even when it has no practical bearing on the costs and benefits of self-protection: the moment of contracting is a reference point that frames the costs and benefits of taking precautions. We present the results of three questionnaire studies in which respondents indicate that they would be more likely to protect their own interests — by requesting a liquidated damages clause, by purchasing a warranty, or by shopping around to ensure the best deal — when the contract is not yet finalized than they would when they understand the agreement to be finalized. We discuss competing explanations for this phenomenon, including both prospect theory and cognitive dissonance. Finally, we explore some doctrinal implications for work on disclosure, modification, and promissory estoppel.
Minimal Region Sufficient for Genome Dimerization in the Human Immunodeficiency Virus Type 1 Virion and Its Potential Roles in the Early Stages of Viral Replication

ABSTRACT It has been suggested that the dimer initiation site/dimer linkage sequence (DIS/DLS) region of the human immunodeficiency virus type 1 (HIV-1) RNA genome plays an important role at various stages of the viral life cycle. Recently we found that the duplication of the DIS/DLS region on viral RNA caused the production of partially monomeric RNAs in virions, indicating that this region indeed mediates RNA-RNA interaction. In this report, we followed up on this finding to identify the necessary and sufficient region for RNA dimerization in the virion of HIV-1. The region thus identified was 144 bases in length, extending from the junction of R/U5 and U5/L stem-loops to the end of SL4. The trans-acting responsive element, polyadenylation signal, primer binding site, upper stem-loop of U5/L, and SL2 were not needed for the function of this region. The insertion of this region into the ectopic location of the viral genome did not affect the level of virion production by transfection. However, the resultant virions contained monomerized genomes and showed drastic reductions in infectivity. A reduction was observed especially in the reverse transcription process. An attempt to generate a replication-competent virus with monomerized genome was performed by the long-term culture of mutant virus-infected cells. All recovered viruses were wild-type revertants, indicating a fatal defect of the mutation. These results suggest that genome dimerization or DIS/DLS itself also plays an important role in the early stages of virus infection.
A time-splitting cooperative spectrum sharing amplify-and-forward relaying protocol with energy harvesting cognitive user

Simultaneous wireless information and power transfer (SWIPT) in energy-constrained wireless sensor networks has attracted considerable attention from the research community due to its promising features in increasing the lifetime devices in addition to mitigate the environment hazards caused by using conventional cell batteries. On the other hand, the advancements in the areas of cooperative spectrum sharing protocols have enabled efficient use of spectrum band between primary and secondary users. Owing to this fact, in this paper, we consider an energy-constrained secondary user which harvests energy from the primary signal and forwards this latter with the guarantee of spectrum access. A time-splitting cooperative spectrum sharing (TS-CSS) at the amplify-and-forward relay is proposed. Assuming a Nakagami-m fading model, exact closed-form expressions for the outage probabilities of the primary and secondary users are derived. From the obtained results, it is shown that the secondary user can carry its own transmission without adversely effecting the performance of the primary user. Furthermore, the effect of various system parameters, such as splitting ratio, distance between nodes and harvesting efficiency, on the system outage performance of these protocols is investigated and several insights are drawn.
Dual agonist SurrobodyTM simultaneously activates death receptors DR 4 and DR 5 to induce cancer cell death

1 = Sanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines, La Jolla, CA 92037; 2 = Sea Lane Biotechnologies, 1400 Terra Bella Avenue, Suite K, Mountain View, CA 94043; 3 = Hokkaido University Graduate School of Medicine, Kita-ku, N15W7, Sapporo, Japan; 4 = Sutro Biopharma, 310 Utah Ave, Suite 150, South San Francisco, CA 94080, 5= Novartis Institutes for Biomedical Research, 4560 Horton Street Bldg. 4, Emeryville, CA 94608; 6 = Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, CA 94080; 7= Oxford BioTherapeutics, 5941 Optical Court, San Jose, CA 95138; 8 = Biometrica, 5627 Oberlin Dr, San Diego, CA 92139 * corresponding author: reedoffice@sanfordburnham.org, phone 858-795-5151, fax 858646-3194
RNA-mediated chaperone type for de novo protein folding

Traditionally the principles of protein folding in vivo have been obtained largely from molecular chaperone studies. Through extensive studies on molecular chaperones, it becomes clear that most proteins can fold without their assistance in vivo, suggesting the existence of other chaperone types and mechanisms. Since all nascent polypeptides are linked to the ribosomes, protein folding in vivo should be understood in the context of vectorial protein synthesis and linkage of nascent chains to ribosome whose major components and basic structural frames are RNAs. Here we introduce a novel RNA-mediated chaperone type and a possible molecular basis for how RNAs can exert chaperoning effect on their linked aggregation-prone polypeptides. Extending potential chaperoning role of ribosome on the bound nascent polypeptide in a cis-acting manner, the findings further suggest a novel function of RNA molecules for protein folding inside cells. RNA interaction-mediated stabilization of folding intermediate against aggregation provides new insights into de novo protein folding in vivo and further extends the functional diversity of RNA molecules.
Indexation de vues virtuelles dans un médiateur XML pour le traitement de XQuery Text

Résumé: Intégrer le traitement de requêtes de recherche d’information dans un médiateur XML est un problème difficile. Ceci est notamment dû au fait que certaines sources de données ne permettent pas de recherche sur mot-clefs et distance ni de classer les résultats suivant leur pertinence. Dans cet article nous abordons l’intégration des fonctionnalités principales du standard XQuery Text dans XLive, un médiateur XML/XQuery. Pour cela nous avons choisi d’indexer des vues virtuelles de documents. Les documents virtuels sélectionnés sont transformés en objets des sources. L’opérateur de sélection du médiateur est étendu pour supporter des recherches d’information sur les documents de la vue. La recherche sur mots-clefs et le classement de résultat sont ainsi supportés. Notre formule de classement de résultats est adaptée au format de données semi-structurées, basé sur le nombre de mots-clefs dans les différents éléments et la distance entre les éléments d’un résultat.
The Effect of a Disease Management Algorithm and Dedicated Postacute Coronary Syndrome Clinic on Achievement of Guideline Compliance

Background The application of disease management algorithms by physician extenders has been shown to improve therapeutic adherence in selected populations. It is unknown whether this strategy would improve adherence to secondary prevention goals after acute coronary syndromes (ACSs) in a largely indigent county hospital setting. Methods Patients admitted for ACS were randomized at the time of discharge to usual follow-up care versus the same care with the addition of a physician extender visit. Physician extender visits were conducted according to a treatment algorithm based on contemporary practice guidelines. Groups were compared using the primary end point of achievement of low-density lipoprotein treatment goals at 3 months after discharge and achievement of additional evidence-based practice goals. Results One hundred forty consecutive patients were randomized. A similar proportion of patients returned for study follow-up in both groups at 3 months (54 [79%]/68 in the usual care group vs 57 [79%]/72 in the intervention group; P = 0.97). Among those completing the 3-month visit, a low-density lipoprotein cholesterol level less than 100 mg/dL was achieved in 37 (69%) of the usual care patients compared with 35 (57%) of those in the intervention group (P = 0.43). There was no statistical difference in implementation of therapeutic lifestyle changes (smoking cessation, cardiac rehabilitation, or exercise) between groups. Prescription rates of evidence-based therapeutics at 3 months were similar in both groups. Conclusion The implementation of a post-ACS clinic run by a physician extender applying a disease management algorithm did not measurably improve adherence to evidence-based secondary prevention treatment goals. Despite initially high rates of evidence-based treatment at discharge, adherence with follow-up appointments and sustained implementation of evidence-based therapies remains a significant challenge in this high-risk cohort.
Insulin-like Growth Factor (IGF)-binding Protein 5 Forms an Alternative Ternary Complex with IGFs and the Acid-labile Subunit*

Up to 90% of circulating insulin-like growth factors (IGF-I and IGF-II) are carried in heterotrimeric complexes with a binding protein (IGFBP) and a liver-derived glycoprotein known as the acid-labile subunit. IGFBP-3 is considered unique among the six well characterized IGFBPs in its ability to complex with the acid-labile subunit. However, a basic carboxyl-terminal domain of IGFBP-3, known to be involved in its interaction with the acid-labile subunit, is shared by IGFBP-5, suggesting the possibility of ternary complexes containing IGFBP-5. We now demonstrate using three independent methods that human IGFBP-5, when occupied by IGF-I or IGF-II, forms ternary complexes of approximately 130 kDa with the acid-labile subunit. IGFBP-3 competes with approximately twice the potency of IGFBP-5 for the formation of such complexes. No other IGFBP complexes with the acid-labile subunit itself or competes with IGFBP-5 for complex formation. As observed for IGFBP-3, ternary complexes containing IGFBP-5 form preferentially in the presence of IGF-I, even though IGFBP-5 has a preferential affinity for IGF-II over IGF-I. By size fractionation chromatography, serum IGFBP-5 co-elutes predominantly with ternary complexes. The demonstration of IGFBP-5-containing ternary complexes indicates an unrecognized form of IGF transport in the circulation and an additional mechanism for regulating IGF bioavailability.
Nutrient responses to ecosystem disturbances from annual to multi-millennial timescales.

The Novus Network annual meeting was held at H. J. Andrews Experimental Forest in Oregon, USA, from 22 May to 24 May 2013.The topicwas: ‘Nutrient responses to ecosystemdisturbances from annual to multi-millennial timescales’. The 2013 workshop brought together 28 researchers from 21 institutions spread across three continents. The participants – 17 faculty members, five postdoctoral researchers and four graduate students – were chosen for variety in background, methods and research programs. All those involved focus on the questions of plant and ecosystem response to disturbance, but at a variety of temporal scales – ranging from one to million year spans. The network is open to any individual with an interest in ecosystem response to disturbance. The goals of the network are: (1) to unify research and records of ecosystem disturbance and response across multiple timescales, from initial seasonal responses to long-term, millennial dynamics and longer; (2) to synthesize current conceptual research in the area of ecosystem disturbance and biogeochemical response; (3) to propose new methodologies; and (4) to guide young scientists.
Instrumental activities of daily living performance and role satisfaction in people with and without mild cognitive impairment: a pilot project.

OBJECTIVE We investigated differences in observed performance of instrumental activities of daily living (IADLs) and self-reported satisfaction with social role performance between people with amnestic mild cognitive impairment (a-MCI) and age- and gender-matched control participants. METHOD We measured observed performance of 14 IADLs using the Independence, Safety, and Adequacy domains of the Performance Assessment of Self-Care Skills (PASS) and the Patient-Reported Outcomes Measurement Information Systems (PROMIS) to examine satisfaction with social role performance. RESULTS Total PASS scores were significantly lower in participants with a-MCI (median=40.6) than in control participants (median=44.2; p=.006). Adequacy scores were also significantly lower. No significant differences were found between groups on the PROMIS measures. CONCLUSION IADL differences between groups were related more to errors in adequacy than to safety and independence. Occupational therapy practitioners can play a key role in the diagnosis and treatment of subtle IADL deficits in people with MCI.
Power Quality Analysis Using Wavelet Transform: A Review

With an increased use of nonlinear loads, sensitive electronic equipments and variable frequency drives power quality has become a prominent issue these days. The development of new methods for detection classification and analysis of power quality is a major concern now a day. This paper presents a literature review of the application of wavelet transforms in the detection and analysis of power quality. The signal under analysis is often polluted by noises, under this situation the extraction of features becomes a difficult task, especially when the noise present in signal has high frequency spectrum which overlap with the frequency of fault. In this paper the de-noising methods are discussed. This review also presents the use of wavelet in other fields of power system and advantages of wavelet transform over other signal processing tools.
Trimethylamine‐N‐oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial

SCOPE Trimethylamine-N-oxide (TMAO), a metabolite linked to the gut microbiota, is associated with excess risk of heart disease. We hypothesized that (i) TMAO response to animal source foods would vary among healthy men and (ii) this response would be modified by their gut microbiome. METHODS AND RESULTS A crossover feeding trial in healthy young men (n = 40) was conducted with meals containing TMAO (fish), its dietary precursors, choline (eggs) and carnitine (beef), and a fruit control. Fish yielded higher circulating and urinary concentrations of TMAO (46-62 times; p < 0.0001), trimethylamine (8-14 times; p < 0.0001), and dimethylamine (4-6-times; P<0.0001) than eggs, beef, or the fruit control. Circulating TMAO concentrations were increased within 15 min of fish consumption, suggesting that dietary TMAO can be absorbed without processing by gut microbes. Analysis of 16S rRNA genes indicated that high-TMAO producers (≥20% increase in urinary TMAO in response to eggs and beef) had more Firmicutes than Bacteroidetes (p = 0.04) and less gut microbiota diversity (p = 0.03). CONCLUSION Consumption of fish yielded substantially greater increases in circulating TMAO than eggs or beef. The higher Firmicutes to Bacteroidetes enrichment among men exhibiting a greater response to dietary TMAO precursor intake indicates that TMAO production is a function of individual differences in the gut microbiome.
Depressive disorder among Turkish women in the Netherlands: A qualitative study of idioms of distress

The provision of mental health services to immigrants in the Netherlands is hampered by difficulty in establishing valid diagnoses of psychiatric disorders. To improve the process of diagnosing depressive disorder among Turkish women in Dutch mental healthcare, we conducted a qualitative study of women with depression in Rotterdam. A bilingual Turkish–Dutch diagnostic interview was developed to explore Turkish women's idioms of distress. Interviews were conducted with 20 women with a disputed diagnosis of depression. Results showed that distress among the Turkish women was characterized by a wide range of somatic complaints, with anxiety and agitation occurring as frequently as depressive complaints. Because the range of complaints is so varied, major depression may be underdiagnosed in the Turkish immigrant population.
Uncertainty measures in an ambient intelligence environment

In this paper we apply the Fuzzy Entropy and Approximate Entropy measures to the Activities of Daily Living (ADL) for a set of elderly subjects in their own homes, and compare the entropy measures against a simpler count of activity transitions. The aim is to assess whether a single relatively simple measure can give an overview of the ADL in order to provide summaries of the wellbeing of an elderly person for their carers or relatives. We find that both the entropy measures and activity count vary considerably between different elderly people, and from day to day. The absolute level of these measures seems to be indicative of different ADL levels. However, it appears that further analysis over a longer period and with more annotation by the volunteers is necessary before the measures can be appropriately interpreted.
Dexfenfluramine: action with estradiol on food intake and body weight in ovariectomized rats.

Previous work from this laboratory has shown that chronic administration of dexfenfluramine (DF) caused substantial weight loss in rats that were overweight 3-4 mo after ovariectomy (OVX), but not in OVX rats that were of normal weight, as a result of estrogen replacement. The present study was conducted to determine whether the enhanced weight loss in the former group is because of either overweight per se or an inhibitory effect of estrogen on DF. Starting either 0, 6, or 14 wk after OVX, when weight gain was zero, moderate, or near maximal, respectively, rats received a 12-day regimen of either estradiol or the oil vehicle and either DF (3 mg.kg-1.day-1 by osmotic minipump) or no drug. DF had no effect on either food intake or weight gain of groups treated during 0-2 wk after OVX but had significant anorectic and weight loss actions in groups treated 6-8 and 14-16 wk after OVX. Estrogen had a similar effect at all three times and in the 14-wk group produced an effect that was additive with that of DF. Measures of plasma glucose and triglycerides and adipose tissue lipoprotein lipase activity did not correlate with the effectiveness of the drug to promote weight loss.
Evidence-Based Infection Control Planning Based on National Healthcare-Associated Infection Prevalence Data

This study identifies factors associated with a high prevalence of healthcare-associated infection (HAI) in the Scottish inpatient population, on the basis of the Scotland National HAI Prevalence Survey data set. The multivariate models developed can be used to predict HAI prevalence in specific patient groups to help with planning and policy in infection control.
Tryptophans in membrane proteins: indole ring orientations and functional implications in the gramicidin channel.

Orientational constraints generated from solid-state NMR of uniformly aligned gramicidin A in hydrated lipid bilayers have been used to determine the indole ring orientations for the four tryptophans of the gramicidin A monomer with respect to the bilayer normal and the channel axis. 15N epsilon 1 labeled tryptophan has been incorporated into gramicidin at positions 9, 11, 13, and 15. The chemical shift tensor orientation has been oriented with respect to the N-H bond via doubly labeled sample in which the 15N epsilon 1-1H has been exchanged for 2H. By observation of the dipolar coupled 15N chemical shift powder pattern of the amino acid, sigma cc has been shown to be perpendicular to the plane of the ring and that sigma aa makes an angle of 25 degrees with respect to the N-H bond. The indole ring orientations were obtained from a consideration of both the chemical shift and the 15N-1H dipolar interaction. These four rings have very similar orientations with respect to the bilayer normal as given by the range of angles between the bilayer and ring normals (64-67 degrees). Furthermore, the N-H bond orientations with respect to the bilayer normal varies by only 10 degrees among the four sites. This orientational analysis has been based on an assumption that large amplitude librational motions in the hydrated bilayer samples are not averaging the nuclear spin interactions. This assumption was verified by analyzing the 2H quadrupole spectra of d5-Trp11-labeled gramicidin A in oriented preparations. The orientations predicted for the five C-H bonds in the indole ring from the 15N data agreed (root-mean-square deviation of 3.7 degrees) with the observed orientations from quadrupole splittings of the C-D bonds in the ring. From the orientation of the indole rings with respect to the bilayer normal and a polypeptide backbone conformation, the four typtophans of the gramicidin monomer are oriented with respect to the backbone of the channel conformation. The similarity among the indole orientations with respect to the bilayer normal is therefore consistent with the electrophysiological results that the individual replacement of the indole rings with phenyl rings results in a incremental decrease in the conductance of the channels formed. The indole orientations with respect to the backbone as defined by the side-chain torsion angles is not uniquely determined but yields a discrete set of possible values. (ABSTRACT TRUNCATED AT 400 WORDS)