Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Interest Rate Fluctuations and the Amman Stock Exchange and Real Estate: An Analytical Study

٢٠١٥/١/٢٦ :ملاتسلاا خيرات ٢٠١٥/١٠/٢٦ :لوبقلا خيرات This paper aims to identify the relationship between interest rate fluctuations, the Jordanian markets of stocks, and real estate in terms of trading volume, the price index of the stock market in general, and the shares of the Jordanian real estate companies listed in Amman Stock Exchange as the Jordanian representative of the real estate market.
Structure and function of asterosaps, sperm-activating peptides from the jelly coat of starfish eggs

Summary Jelly coat of starfish eggs has the capacity to activate homologous spermatozoa and induce the acrosome reaction. We have isolated 12 sperm-activating peptides (SAPs) from the egg jelly of the starfish, Asterias amurensis. Eleven SAPs were structurally identified by sequence analysis and electro-spray ionisation mass spectrometry. All of them are glutamine-rich tetratriacontapeptides with an intramolecular disulphide linkage between Cys8 and Cys32. They are much larger than sea urchin SAPs and do not show any significant sequence similarities to known proteins. Thus we have collectively named them asterosaps. The amino terminal region, where structural diversity of asterosaps is observed, is not important for their activity, whereas the disulphide linkage is essential. Asterosaps do not induce the acrosome reaction by themselves, but are able to induce the acrosome reaction in combination with an egg jelly glycoconjugate named ARIS. Furthermore, anti-asterosap rabbit antibody significantly decreased the acrosome reaction-inducing activity of the jelly solution and the activity was restored by addition of excess asterosap. These results support our hypothesis that the main physiological role of SAPs is the induction of the acrosome reaction in cooperation with two other jelly components, ARIS and Co-ARIS.
Management of the upper limb with botulinum toxin type A in children with spastic type cerebral palsy and acquired brain injury: clinical implications

The aim of this article is to describe our clinical experience in treating muscle imbalance in 49 children with spastic upper extremity involvement. We discuss four cohorts of children treated with botulinum toxin type A (BTX‐A), each with different treatment objectives. In the first group, 27 children were treated for functional improvement and, of these, 23 had a positive effect, while four had no objective benefit. In the second group, eight children were treated for purposes of presurgical planning; of these, four were referred for surgery, three continued with serial treatment and one child did not benefit from injection. The third group comprised six children who were treated to improve posture and care: in this group, four children demonstrated clear benefit and two children lost some function subsequent to injection. Finally, a fourth group of seven children were treated after acquired brain injury (three with severe tetraplegia, four with hemiplegia). In this group, all children experienced spasticity relaxation and two children with hemiplegia also gained functional benefit. In terms of adverse events, deterioration of upper extremity function was poorly tolerated but limited to the first 1–3 weeks postinjection. Grip strength or thumb grip were diminished if too high doses were used. Overall, our results with BTX‐A were rewarding in children with no fixed contracture, good motor learning capacity and high motivation to train. Additionally, BTX‐A treatment has proven valuable for counteracting spasticity in children with acquired brain injury. This treatment modality may not, however, be an appropriate treatment option for all children with severe upper extremity spasticity, due to the shorter duration of effect and the potential reduction in functional abilities seen in this cohort. In all cases, the selection of muscles to be treated needs careful clinical assessment. Dynamic EMG analysis should be performed whenever required to aid muscle selection, especially in children with spasticity combined with dystonia. Evaluation of M‐responses suggests that for the forearm muscles, doses of BTX‐A above 1.5 U/kg/muscle should not be used.
BAliBASE (Benchmark Alignment dataBASE): enhancements for repeats, transmembrane sequences and circular permutations

BAliBASE is specifically designed to serve as an evaluation resource to address all the problems encountered when aligning complete sequences. The database contains high quality, manually constructed multiple sequence alignments together with detailed annotations. The alignments are all based on three-dimensional structural superpositions, with the exception of the transmembrane sequences. The first release provided sets of reference alignments dealing with the problems of high variability, unequal repartition and large N/C-terminal extensions and internal insertions. Here we describe version 2.0 of the database, which incorporates three new reference sets of alignments containing structural repeats, trans-membrane sequences and circular permutations to evaluate the accuracy of detection/prediction and alignment of these complex sequences. BAliBASE can be viewed at the web site http://www-igbmc.u-strasbg. fr/BioInfo/BAliBASE2/index.html or can be downloaded from ftp://ftp-igbmc.u-strasbg.fr/pub/BAliBASE2 /.
Spectral imaging for complex clinical breast structures

We have imaged several breast cancer patients at multiple intervals during her neoadjuvant chemotherapy to assess the capability of microwave tomography as a therapy monitoring device. For the patient discussed here, we illustrate the spectral behavior of our tomographic approach in the context of a complex imaging situation with a large scattering tumor along with less frequently encountered structures such as thickened skin in the tumor vicinity. These results demonstrate that the microwave technology is sensitive to dielectric property perturbations associated with treatment-induced physiological changes. In addition, it also confirms previously hypothesized notions that the lower frequency images provide lower resolution but useful counterparts to the enhanced resolution, higher frequency images. This spectral data can be instructive for both UWB radar approaches and multi-frequency or time-domain tomographic approaches. The chemotherapy patients are unique with respect to breast cancer imaging cases in that they usually involve electrically large tumors along with other non-standard features such as extra-thick skin (easily as thick as 1 cm). These large, high contrast features are quite challenging for all types of microwave imaging (radar and tomography-based) and form an important benchmark for testing imaging techniques. For our efforts, we have developed a log transformation as part of the image reconstruction process which we have shown to have superior convergence behavior (i.e. no local minima) while retaining phase wrapping information that is generally lost when only considering more classical minimization criteria. As we will show, this technique requires broadband scattering data which we provide from measurements using our ultrawideband monopole antennas.
Chromosome separation and exit from mitosis in budding yeast: dependence on growth revealed by cAMP-mediated inhibition.

Cell cycle progression of somatic cells depends on net mass accumulation. In Saccharomyces cerevisiae the cAMP-dependent kinases (PKAs) promote cytoplasmic growth and modulate the growth-regulated mechanism triggering the begin of DNA synthesis. By altering the cAMP signal in budding yeast cells we show here that mitotic events can also depend on growth. In fact, the hyperactivation of PKAs permanently inhibited both anaphase and exit from mitosis when cell growth was repressed. In S. cerevisiae the anaphase promoting complex (APC) triggers entry into anaphase by mediating the degradation of Pds1p. The cAMP pathway activation was lethal together with a partial impairment of the Cdc16p APC subunit, causing a preanaphase arrest, and conversely low PKA activity suppressed the lethality of cdc16-1 cells. Deregulated PKAs partially prevented the decrease of Pds1p intracellular levels concomitantly with the anaphase inhibition, and the PKA-dependent preanaphase arrest could be suppressed in pds1(-) cells. Thus, the cAMP pathway and APC functionally interact in S. cerevisiae and Pds1p is required for the cAMP-mediated inhibition of chromosome separation. Exit from mitosis requires APC, Cdc15p, and the polo-like Cdc5p kinase. PKA hyperactivation and a cdc15 mutation were synthetically lethal and brought to a telophase arrest. Finally, a low cAMP signal allowed cell division at a small cell size and suppressed the lethality of cdc15-2 or cdc5-1 cells. We propose that mitosis progression and the M/G1 phase transition specifically depend on cell growth through a mechanism modulated by PKAs and interacting with the APC/CDC15/CDC5 mitotic system. A possible functional antagonism between PKAs and the mitosis promoting factor is also discussed.
An X-band to Ku-band RF MEMS switched coplanar strip filter

Radio frequency microelectromechanical systems (RF MEMS) are key enabling technologies for miniature reconfigurable circuits such as microwave filters. We present a two-pole monolithic RF MEMS switched filter, fabricated on GaAs, that employs surface-micromachined capacitors to present a variable capacitance to a coupled coplanar strip filter, thereby switching the filter center frequency 37% between 10.7 GHz and 15.5 GHz with voltages of 20 and 0 V, respectively. This 15% bandwidth filter occupies a chip area of 2.2 /spl times/1.5 mm and demonstrates less than 2-dB of loss, making it promising for numerous applications within these critical frequency bands.
The Consequences of “Options” in the Directive 2013/34/Eu of the European Parliament and of the Council on the Financial Statements

Directive 13/34/EC of the European Parliament and of the Council of 26 June 2013 on the annual financial statements, consolidated financial statements and related reports of certain types of undertakings is an instrument of the harmonisation of accounting in member states of the European Union. The Directive contains a number of various ways for recognition and measurement of financial statements, alternative forms of statements or simplifications for small and medium sized enterprises, worded as “permit or require”. On the one hand, these differing ways can facilitate application of the Directive in national legislations; on the other hand, they can significantly reduce the comparability of information published in financial statements. The aim of the paper is to verify the relation between the options to be chosen and the variability of the resulting values of the financial statement items. Based on the findings, the results are evaluated in relation to the informative function of financial reporting.
Endometrial Papillary Adenocarcinomas: Two Clinicopathological Types

SummaryThirty-four patients with primary endometrial papillary adenocar-cinoma diagnosed in our institution from 1970 to 1982 were studied. Papillary adenocarcinomas represented 10% of all endometrial adenocarcinomas seen during this period. Papillary neoplasms were morphologically subclassified as either papillary serous adenocarcinoma or welt-differentiated papillary adenocarcinoma, following review of the histological sections obtained prior to radiotherapy or chemotherapy. Twenty-five patients were found to have papillary serous adenocarcinoma, and nine had well-differentiated papillary adenocarcinoma. A control group of 305 patients with endometrial adenocarcinoma of nonpapillary type was compared with respect to age, race, and survival. Fifty percent of the patients with papillary serous adenocarcinoma were black and they were significantly older (p = 0.001) than the control group, with a mean age of 71 years. Thirty percent of the papillary serous adenocarcinoma group had deep myometrial invasion and peritoneal surface involvement by tumor. In 20% of these patients there was a discrepancy between the clinical stage and the surgical stage at laparotomy. Survival was markedly worse (p = 0.01) than that of the control group. Patients with well-differentiated papillary adenocarcinomas were similar to control patients with respect to age and racial status and had similar clinical survival outcome. We conclude that well-differentiated papillary adenocarcinoma of the endometrium is a distinct form of papillary adenocarcinoma, and must be morphologically and clinically distinguished from papillary serous adenocarcinomas because of its better prognosis. Morphological differentiation of these two papillary variants of endometrial adenocarcinoma is presented.
Realized collaboration across borders - Linux and the bioinformatic part

In year 2006 Biolinux inter alia with the work of Tim Booth gives its rise and provide an operating system that was and is specialized in providing an environment for the needs of bioinformatics. Since than some years have been seen and the information about Biolinux has not only widespread within the bio-science community, also the Linux community at whole had a ear for it. This has caused a process called collaboration across borders and makes as the keywords say the different work groups cooperating together. In this paper we will have a look into the history of this collaboration, will show its growth until we reach the actual state and we will talk about the quo vadis of this process.
Determination of Vascular Waterfall Phenomenon by Bedside Measurement of Mean Systemic Filling Pressure and Critical Closing Pressure in the Intensive Care Unit

BACKGROUND: Mean systemic filling pressure (Pmsf) can be determined at the bedside by measuring central venous pressure (Pcv) and cardiac output (CO) during inspiratory hold maneuvers. Critical closing pressure (Pcc) can be determined using the same method measuring arterial pressure (Pa) and CO. If Pcc > Pmsf, there is then a vascular waterfall. In this study, we assessed the existence of a waterfall and its implications for the calculation of vascular resistances by determining Pmsf and Pcc at the bedside. METHODS: In 10 mechanically ventilated postcardiac surgery patients, inspiratory hold maneuvers were performed, transiently increasing Pcv and decreasing Pa and CO to 4 different steady-state levels. For each patient, values of Pcv and CO were plotted in a venous return curve to determine Pmsf. Similarly, Pcc was determined with a ventricular output curve plotted for Pa and CO. Measurements were performed in each patient before and after volume expansion with 0.5 L colloid, and vascular resistances were calculated. RESULTS: For every patient, the relationship between the 4 measurements of Pcv and CO and of Pa and CO was linear. Baseline Pmsf was 18.7 ± 4.0 mm Hg (mean ± SD) and differed significantly from Pcc 45.5 ± 11.1 mm Hg (P < 0.0001). The difference of Pcc and Pmsf was 26.8 ± 10.7 mm Hg, indicating the presence of a systemic vascular waterfall. Volume expansion increased Pmsf (26.3 ± 3.2 mm Hg), Pcc (51.5 ± 9.0 mm Hg), and CO (5.5 ± 1.8 to 6.8 ± 1.8 L · min−1). Arterial (upstream of Pcc) and venous (downstream of Pmsf) vascular resistance were 8.27 ± 4.45 and 2.75 ± 1.23 mm Hg · min · L−1; the sum of both (11.01 mm Hg · min · L−1) was significantly different from total systemic vascular resistance (16.56 ± 8.57 mm Hg · min · L−1; P = 0.005). Arterial resistance was related to total resistance. CONCLUSIONS: Vascular pressure gradients in cardiac surgery patients suggest the presence of a vascular waterfall phenomenon, which is not affected by CO. Thus, measures of total systemic vascular resistance may become irrelevant in assessing systemic vasomotor tone.
Fur-Mediated Activation of Gene Transcription in the Human Pathogen Neisseria gonorrhoeae

ABSTRACT It is well established that the ferric uptake regulatory protein (Fur) functions as a transcriptional repressor in diverse microorganisms. Recent studies demonstrated that Fur also functions as a transcriptional activator. In this study we defined Fur-mediated activation of gene transcription in the sexually transmitted disease pathogen Neisseria gonorrhoeae. Analysis of 37 genes which were previously determined to be iron induced and which contained putative Fur boxes revealed that only 30 of these genes exhibited reduced transcription in a gonococcal fur mutant strain. Fur-mediated activation was established by examining binding of Fur to the putative promoter regions of 16 Fur-activated genes with variable binding affinities observed. Only ∼50% of the newly identified Fur-regulated genes bound Fur in vitro, suggesting that additional regulatory circuits exist which may function through a Fur-mediated indirect mechanism. The gonococcal Fur-activated genes displayed variable transcription patterns in a fur mutant strain, which correlated with the position of the Fur box in each (promoter) region. These results suggest that Fur-mediated direct transcriptional activation is fulfilled by multiple mechanisms involving either competing with a repressor or recruiting RNA polymerase. Collectively, our studies have established that gonococcal Fur functions as an activator of gene transcription through both direct and indirect mechanisms.
Random amplified polymorphic DNA variation among remnant big bluestem (Andropogon gerardii Vitman) populations from Arkansas’ Grand Prairie

Random amplified polymorphic DNA (RAPD) analysis was used to characterize genetic diversity and genetic distinctiveness of Andropogon gerardii from remnant Arkansas prairies. Six oligonucleotide primers, which generated 37 RAPD bands, were used to analyse 30–32 plants from six Grand Prairie populations, Baker Prairie (Arkansas Ozarks), two Illinois prairies and two cultivars. Genetic diversity of the Arkansas remnants ranged from 82.7 to 99.3%, with 89% of the total genetic variation within and 11% among populations. The partitioning of genetic variation was consistent with that reported for other outcrossing perennial grasses, using the more conservative allozyme markers. Principal component analysis indicated a northern and southern association within Arkansas’ Grand Prairie. Although there was no genetic structuring at the landscape level, the Illinois prairies and cultivars were different from all Arkansas prairies tested. There was significant within‐population structuring in four of the seven Arkansas remnants, with a negative relationship between genetic similarity and geographical distance. The three nonstructured populations were from a linear railroad remnant, suggesting different population‐level dynamics from nonlinear prairies. The results of this study indicated that small isolated remnant big bluestem populations were not genetically depauperate and that genetic relationships among populations could not be predicted solely on geographical proximity.
Interdisciplinary approaches for deep learning

The Norwegian national curricula for primary and secondary education are currently undergoing reforms, which will be implemented from 2020. The underlying documents regarding the reform are studied in this article, and conclude that learners should be provided with beneficial conditions to develop values and knowledge to manage their lives well. An essential notion is ‘deep learning’ whose implication seems to be acquisition of more in-depth knowledge and understanding of subject areas. The present article argues that learning is about making connections, whether it be noticing connections between isolated subject areas, or, perhaps, between theoretical concepts and practical tasks. Further, the article argues that interdisciplinary approaches extend knowledge as they typically work across subject areas and support learners in discovering disciplinary connections. Claims are made that interdisciplinary strategies have the capacities to facilitate various learning styles, motivation and variation. Such facilitations are required in education that is democratic and which targets all learners. Hence, the article argues that interdisciplinarity and deep learning are concepts that work together, and in which critical thinking and creativity are core elements. The argumentation is based on the four official documents NOU 2014:7, NOU 2015:8, Report to the Storting 28, The Standing Committee on Education, Research and Church Affairs’ recommendation to the Storting 19 S, as well as, data findings discussed in a master study which discusses teachers’ perceptions of interdisciplinarity and learning.
Single-Feed Dual-Band Circularly Polarized Dielectric Resonator Antenna for CNSS Applications

A cross-slot-coupled dual-band circularly polarized rectangular dielectric resonator antenna (RDRA) with a small frequency ratio (1.23) based on compass navigation satellite system (CNSS) applications is designed, fabricated, and measured. The RDRA is excited to resonate at two pairs of near-degenerate orthogonal modes of TE111 and TE113, and a cross slot is introduced to simultaneously achieve dual-band right-hand circular polarization. The measured −10 dB impedance bandwidths of 11.4% and 8.4%, 3-dB axial ratio (AR) bandwidths of 2.1% and 2.2%, and antenna gains of over 5.4 and 4.3 dBic are obtained for CNSS B3 and B1 bands, respectively. Reasonable consistency is achieved between measured and simulated results of reflection coefficients, ARs, and radiation patterns.
Identification and characterization of a novel CXC chemokine in xenograft tumor induced by mas‐overexpressing cells

Overexpressions of G protein‐coupled receptor (GPCR) with elevated downstream signaling events have been reported in various tumors. However, the cellular mechanism that GPCR overexpression leads to tumor formation is largely unknown. The orphan GPCR mas was originally isolated from a human epidermoid carcinoma. In vivo studies of mas‐overexpressing cells suggested that xenograft tumor formation was positively correlated with the levels of mas expression. Histochemical analysis indicated that xenograft tumor consisted of mas‐transfected and stromal cells. Biochemical analyses revealed that cells overexpressing mas exhibited significantly increased anchorage‐independent growth, whereas there was no significant difference in cell proliferation in comparison with empty vector‐transfected control cells. Expression profiling using mRNA differential display and Northern analysis indicated an elevated expression of GRO and a novel CXC chemokines, tumor‐induced factor (TIF), in mas‐transfected cells and xenograft tumor. Bacterially expressed recombinant TIF was found to act as a neutrophil chemoattractant in a chemotactic assay. These results suggest that mas overexpression enables anchorage‐independent growth of transformed cells, and interplays of secreted chemokines with stromal cells modulate xenograft tumor formation. Importantly, a novel CXC chemokine, TIF, was identified in the xenograft tumor tissues. © 2009 UICC