Miracle-dz/UniFAR-FTUs huggingface dataset:
Fourth malignancy after treatment of Hodgkin's lymphoma: a case report.

OBJECTIVE To evaluate the incidence and treatment of the fourth malignancy in a Hodgkin's lymphoma (HL) patient. METHODS We reported a HL patient after treatment that developed the second, third, and fourth malignancies (chronic myeloid leukemia, chronic lymphocytic leukemia, and gastric adenocarcinoma) in relatively short time (75 months). The diagnosis was confirmed by pathology, bone marrow morphology, flow cytometry, karyotype and fusion gene examination. RESULTS He received surgery and chemotherapy. He achieved good response for triple malignancies. After diagnosis with gastric cancer, he orally administered compound tegafur capsule, apatinib and imatinib. CONCLUSION The fourth malignancy of HL patient is extremely rare. We recommend a strict follow-up, for HL to detect multiple malignancies.
Differential effects of high‐frequency repetitive transcranial magnetic stimulation over ipsilesional primary motor cortex in cortical and subcortical middle cerebral artery stroke

Facilitation of cortical excitability of the ipsilesional primary motor cortex (M1) may improve dexterity of the affected hand after stroke. The effects of 10Hz repetitive transcranial magnetic stimulation (rTMS) over ipsilesional M1 on movement kinematics and neural activity were examined in patients with subcortical or cortical stroke.
Mutational and in vitro protein-binding studies on centromere DNA from Saccharomyces cerevisiae

Centromeres on chromosomes in the yeast Saccharomyces cerevisiae contain approximately 140 base pairs (bp) of DNA. The functional centromere (CEN) region contains three important sequence elements (I, PuTCACPuTG; II, 78 to 86 bp of high-AT DNA; and III, a conserved 25-bp sequence with internal bilateral symmetry). Various point mutations or deletions in the element III region have a profound effect on CEN function in vivo, indicating that this DNA region is a key protein-binding site. This has been confirmed by the use of two in vitro assays to detect binding of yeast proteins to DNA fragments containing wild-type or mutationally altered CEN3 sequences. An exonuclease III protection assay was used to demonstrate specific binding of proteins to the element III region of CEN3. In addition, a gel DNA fragment mobility shift assay was used to characterize the binding reaction parameters. Sequence element III mutations that inactivate CEN function in vivo also prevent binding of proteins in the in vitro assays. The mobility shift assay indicates that double-stranded DNAs containing sequence element III efficiently bind proteins in the absence of sequence elements I and II, although the latter sequences are essential for optimal CEN function in vivo.
Evolution of gases and particles from a savanna fire in South Africa

average OH concentration in the plume was � 1.7 � 10 7 molecules cm � 3 . Excess CN, normalized by excess CO, decreased rapidly during the first � 5 min of aging, probably due to coagulation, and then increased, probably due to gas-to-particle conversion. The CO-normalized concentrations of particles 1.5 mm diameter increased, with smoke age. The spectral depletion of solar radiation by the smoke is depicted. The downwelling UV flux near the vertical center of the plume was about two-thirds of that near the top of the plume. INDEX TERMS: 0315 Atmospheric Composition and Structure: Biosphere/atmosphere interactions; 0317 Atmospheric Composition and Structure: Chemical kinetic and photochemical properties; 0322 Atmospheric Composition and Structure: Constituent sources and sinks; 0345 Atmospheric Composition and Structure: Pollution—urban and regional (0305); 3374 Meteorology and Atmospheric Dynamics: Tropical meteorology; KEYWORDS: gases, particles, biomass fires, smoke, savanna fires, evolution of smoke
Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw110.

Transfection experiments with plasmids containing immediate early (IE) genes of herpes simplex virus type 1 (HSV-1) have previously demonstrated a role for the IE polypeptide Vmw110 (ICP0) in stimulating expression from plasmid-encoded early gene promoters. To gain further insights into the function of Vmw110 we isolated a deletion mutant specifying a truncated form of the polypeptide which had been shown to be inactive in transfection assays. This mutant, dl1403, contained a 2 kb deletion within both the TRL and IRL copies of the Vmw110 gene, and encoded a polypeptide consisting of the original N-terminal 105 amino acids followed by 56 amino acids specified by a reading frame not used by Vmw110. dl1403 was able to replicate and produce plaques on baby hamster kidney (BHK) cells but the yield of infectious virus was 20- to 100-fold lower than obtained with wild-type HSV-1. Surprisingly, comparison of polypeptide synthesis, DNA replication and DNA encapsidation in cells infected with 5 p.f. u. /cell dl1403 or wild-type HSV-1 revealed no significant differences. In addition similar numbers of particles were produced in cells infected with the two viruses, resulting in stocks of dl1403 exhibiting significantly higher particle/p.f. u. ratios. The efficiency of plaquing of dl1403 was greatly reduced in Vero and human foetal lung cells compared with BHK cells, but following infection with 5 p.f. u. /cell similar yields of infectious virus were obtained from all three cell lines. Marker rescue experiments verified that the reduced yield of dl1403 in BHK cells was a consequence of the deletion within the Vmw110 gene. The results suggest that the effect of this deletion is manifest primarily at low multiplicities of infection and can be largely overcome by increasing the virus dose.
MR imaging adds weight to sacroiliitis diagnosis November 05

Early diagnosis of rheumatoid arthritis and monitoring of the disease during therapy have attracted considerable interest over the past decade. Imaging studies of seronegative spondyloarthropathies, however, are few and far between, even though these disorders occur as frequently as rheumatoid arthritis. Now the potential promise of biological therapy to treat ankylosing spondylitis, one of the most disabling seronegative spondyloarthropathies, is focusing attention on techniques capable of detecting the disease early and tracking its progress through treatment.
Role of dorsal and ventral stream development in biological motion perception

Little is known about the functional development of dorsal and ventral visual streams. The right posterior superior temporal sulcus (pSTS) represents a pivotal point of the two streams and is involved in the perception of biological motion. Here, we compared brain activity between children (aged 5–7 years) and adults (aged 20–32 years) while they were viewing point-light dot animations of biological motion. Biological motion-related activation was found in right pSTS of adults, and in right fusiform gyrus and left middle temporal lobe of children. Group comparisons revealed increased activity in pSTS for adults and in fusiform gyrus for children. Only poorly performing children showed fusiform gyrus activity. These findings indicate that pSTS functioning is not adult-like at the age of 6 years.
Biomarkers for Bisphosphonate-Related Osteonecrosis of the Jaw.

PURPOSE The aim of this study was to investigate a possible biomarker for bisphosphonate-related osteonecrosis of the jaw (BRONJ) in an animal model. MATERIALS AND METHODS Forty-eight Sprague-Dawley rats were randomly divided into the bisphosphonate group (n = 36), who were injected once a week with zoledronic acid, and the control group (n = 12), who were injected once a week with saline. After 6 weeks, surgical intervention was performed, and injections were continued up to 8 weeks. Rats in the bisphosphonate group were then further classified to the ONJ group, and the non-ONJ group, and biomarkers, including CTx, Glu-OC, TRACP 5b, RANKL, and OPG, were assessed at baseline (T0), at surgical intervention (T1), and at sacrifice (T2). Histomorphometric analysis for quantification of osteoclasts was performed. RESULTS Repeated measures analysis of variance revealed that TRACP 5b levels and the RANKL/OPG ratio were significantly decreased over time in the ONJ group compared with the non-ONJ group (p < .05). At T2, the area under the curve was 0.807 for TRACP 5b (sensitivity: 88.9%, specificity 66.7% at cutoff) and 0.765 for the RANKL/OPG ratio (sensitivity: 77.8%, specificity 62.9% at cutoff). TRACP 5b showed a lower least significant change (29.6%) with lower intra-assay coefficient of variability (CV; 6.32%) and interassay CV (11.20%) compared with those of the RANKL/OPG ratio (39.27%) and showed a higher signal-to-noise ratio (2.76) than that of the RANKL/OPG ratio (1.62). N.Oc/T.Ar and N.Oc/B.Ar demonstrated significantly decreased number of osteoclasts in ONJ group versus non-ONJ group. CONCLUSIONS These results show that serum TRACP 5b and the RANKL/OPG ratio were possible biomarkers for BRONJ. These data may provide useful additional information for future ONJ research. Further studies are needed to validate these results in humans with ONJ.
Online Detection of Abnormal Events in Video Streams

We propose an algorithm to handle the problem of detecting abnormal events, which is a challenging but important subject in video surveillance. The algorithm consists of an image descriptor and online nonlinear classification method. We introduce the covariance matrix of the optical flow and image intensity as a descriptor encoding moving information. The nonlinear online support vectormachine (SVM) firstly learns a limited set of the training frames to provide a basic reference model then updates the model and detects abnormal events in the current frame. We finally apply the method to detect abnormal events on a benchmark video surveillance dataset to demonstrate the effectiveness of the proposed technique.
Fuzzy Temporal Interval Relationship Based on Interval-Valued Fuzzy Sets

Time is an important feature in our real world. From computer science field that research temporal data to spatial information field that research spatial temporal data, the researchers all have considered that the conception of time is important. In many application domains, time is needed to record when the object exists or changes and when the event happens. In general, temporal information is regarded as crisp and is applied in many areas. However, in fact temporal information is not crisp, but is uncertain and vague. Geographic phenomena, such as when the real-estate begins to exchange and when the house is collapsed, have the imprecise temporal information. To represent these uncertain temporal information, in this paper we present fuzzy interval relationship model based on fuzzy interval- valued. And then a new fuzzy interval algebra is presented by extending the Allen's classical interval algebra. The approach naturally is compatible for existing classical temporal model.
Content-guided Navigation in Multimeric Molecular Complexes

In the field of structural biology, molecular visualization is a critical step to study and understand 3D structures generated by experimental and theoretical technics. Numerous programs are dedicated to the exploration and analysis of structures in 3 dimensions. However, very few of them offer navigation algorithms that deal in an intelligent way with the content they display and the task to perform. This observation is emphasized in the case of navigation in immersive environments where users are immersed in their molecular systems, without any spatial landmark to guide their exploration. Starting from this observation, we propose to take into account some geometrical features found in multimeric molecular complexes to provide navigation guides to the users during the exploration process. It is possible thanks to the common symmetrical layout molecular complexes present. Beyond the biological meaning and importance that symmetric layouts have in proteins, they allow us to orient and guide the exploration of molecular complexes in an intelligent and meaningful manner. We present then a current work on the design of navigation paradigms based on the content and the task for the molecular visualization.
Radiation decreases murine small intestinal HCO3− secretion

Purpose: While secretagogue-induced diarrhea is rich in chloride (Cl−) and bicarbonate (HCO3 −) anions, little is known about diarrhea or its anionic composition following irradiation. We performed studies to characterize the differences between cyclic adenosine monophosphate (cAMP)-stimulated anion secretions in irradiated and non-irradiated mice. Materials and methods: HCO3 − secretion was examined in basal, cAMP-stimulated, and irradiated jejunal tissues from BALB/c (Bagg albino) mice. The abdomens of the mice were γ-irradiated using a caesium-137 source. Results: Ussing-chamber experiments performed in an HCO3−-containing, Cl−-free solution on the bath side showed inhibition of HCO3− in irradiated mice. Non-irradiated mice exhibited bumetanide-sensitive and insensitive current, while irradiated mice displayed bumetanide-sensitive current. pH-stat experiments showed inhibition of basal and cAMP-stimulated HCO3− secretions in irradiated mice. Immunohistochemistry and Western blot analysis displayed a sodium-bicarbonate cotransporter expression in the villus and not the crypt of non-irradiated mice, while its expression and protein levels decreased in irradiated mice. Conclusions: Anion secretions in irradiated mice, being primarily Cl− and minimally HCO3−, differ from that of secretagogue-induced anion secretions. Understanding anion loss will help us correct electrolyte imbalances, while reduced HCO3− secretion in the upper-gastrointestinal tract might also have implications for irradiation-induced nausea and vomiting.
[The new antiepileptic drugs: their indications and side effects].

INTRODUCTION Although the significant progress in pharmacotherapy of epilepsy during last decade was achieved, about one third of patients are resistant to the current treatment. The introduction of numerous effective, well tolerated and safe new antiepileptic drugs (AEDs) in the last decade of the 20th century has widened the choice of treatment options in epilepsy and improved the tolerability and the ease of use of treating patients with epilepsy. Nevertheless, significant safety and efficacy deficits continue to exist. Severe idiosyncratic reactions and organ toxicity have hampered the wide use of some of the newer AEDs. As a decade before, about one third of patients with chronic epilepsy is resistant to current pharmacotherapy. Even in patients in whom pharmacotherapy is efficacious, current AEDs do not seem to affect the progression or the underlying natural history of epilepsy. DEVELOPMENT The revision of newer AEDs are formulation, action, doses and side effects. CONCLUSION Thus, there is an unmet need for safer and more effective drugs, especially for chronic, drug-resistant epilepsy. To stimulate the development of even better compounds, the demonstrated benefits and risks of current new AEDs are reviewed.
A study of the range of motion of human fingers with application to anthropomorphic designs

The multifingered human hand serves as a model for anthropomorphic manipulators and prosthetic devices. In order to better guide the design of these devices, a study of the range of motion of human fingers is presented. The role of tendons in the actions of human fingers is modeled and results of experimental studies on the range of motion of fingers in normal humans are presented. Further study of disabled hands illustrates constraints imposed by deficient tendon mechanisms. The basic investigations of normal and disabled hands guide the design of tendon-based actuators for mechanized fingers. The design of a prototype finger actuated by a shape-memory alloy material serving as a tendon is discussed. <<ETX>>
Effects of antimurine interleukin-6 on bacterial translocation during gut-derived sepsis.

BACKGROUND Recent studies have shown that interleukin-6 (IL-6) is involved in the systemic changes that are associated with infection and tissue injury and that there is a correlation between high levels of IL-6 and poor outcome during several pathologic conditions. OBJECTIVE The effects of antimurine IL-6 antibody on survival and host defense were studied in a clinically relevant model of infection. METHODS Balb/c mice were treated with 10 micrograms of antimurine interleukin-6, a nonspecific mouse IgG, or placebo 1 hour before they underwent bacterial challenge by gavage of 10(10) Escherichia coli and burn injury. Survival and the extent of translocation of E coli were determined as well as the correlation between the IL-6 levels and survival times. RESULTS Survival after burn and gavage was 90% in animals treated with antimurine interleukin-6 vs 50% in animals treated with nonspecific IgG and 30% in saline-treated controls. A significant correlation between the levels of IL-6 and survival time was observed. Less translocation and better killing of bacteria were observed in the tissues of animals treated with antimurine interleukin-6. CONCLUSIONS Interleukin-6 appears to play a major role in both the intensity of translocation of E coli from the intestine following burn injury and the host's ability to kill translocated organisms. Improved outcome was associated with a reduction of IL-6 levels by anti-IL-6 antibody.
Modelling apical build-up of auxin

The simplest way of adapting the 6-channel model (Fig 6) to model the data of Brewer et al. [1] is to introduce weak, saturable coupling between the channels, as shown in S6A Fig. The retarding of the 26.5 ng pulse seen in this model can be interpreted as follows: As the uptake increases, and hence the intracellular auxin concentrations rise, saturation makes the lateral permeability effectively smaller. Our previous analysis of the effect of changing coupling strength, Fig 5C and D, tells us that this should decrease the velocity and increase the spreading rate. Both these effects can be seen with the 26.5 ng pulse compared to the lower uptakes. This is consistent with the pea data. However, other features of the pea data, such as the apical build-up of the 26.5 ng apical pulse, are not captured by this model. A more complete match to the data can be achieved by decreasing the strength of the coupling between the two channels furthest from the polar channels (see Fig. 10B); the most distant channel then acts as a reservoir of auxin that only enters the transport stream slowly. However, it is striking that a good match to the data can also be obtained from a rather different model, which has only four channels and features a one-way lateral permeability into the polar channels (S6B Fig).
A pilot study on the effects of treatment with acamprosate on craving for alcohol in alcohol‐dependent patients

This study investigated the effects of treatment with acamprosate on craving for alcohol by using a contextual priming task with alcohol and neutral words and craving questionnaires (ACQ, OCDS) in alcohol‐dependent patients who abstained from alcohol for 6 weeks. The acamprosate‐treated group (n =16) were given 666 mg t.d. s. with standard group‐work aimed at abstinence. The unmedicated control group (n =13) received only standard group therapy. The results showed that the acamprosate treated group was faster in their responses to craving‐related stimuli and scored lower on craving questionnaires during week 6 compared with week 2. Our results suggest that acamprosate may play a role in reduction of craving for alcohol after 6 weeks of treatment.
Adaptive backstepping synchronization for a class of uncertain complex dynamical networks

This paper proposes an adaptive backstepping synchronization method for a class of uncertain complex dynamical network (CDN). The proposed method is applied by transforming the CDN into the nonautonomous strict-feedback form. Moreover, it gurantees the synchronization of all network nodes with an isolated reference one, even though the nodes have some parameter uncertainties. An example is given to demonstraste the effectiveness of the proposed method.
Fruit and vegetable intake as a moderator of the association between depressive symptoms and cigarette smoking

Background: Studies have consistently reported associations among depression, cigarette smoking, and fruit and vegetable intake (FVI). This study evaluated FVI as a moderator of the association between depressive symptoms and smoking. Methods: The authors analyzed data from the National Longitudinal Survey of Youth 1979: Child and Young Adult. The study sample was adults aged 19–33 years at baseline in the year 2004 from the Young Adult Survey portion. Moderation analyses were performed using the Johnson-Neyman technique to assess whether baseline FVI moderated the association between depressive symptoms and smoking status cross-sectionally and as a predictor of smoking cessation longitudinally at 4-year follow-up. Results: Cross-sectionally, at lower levels of FVI (<4.9 times/day), there was a significant association between smoking and depressive symptoms (P < .05), but not at higher levels of FVI (≥4.9 times/day; P > .05). Longitudinally, there was an inverse association between depressive symptoms and quitting smoking at FVI <1.2 times/day (P < .05), but there was not a significant association at FVI ≥1.2 times/day (P ≥ .05). Conclusions: FVI moderated the association between depressive symptoms and cigarette smoking cross-sectionally and longitudinally. The cross-sectional findings might be partially explained by the longitudinal findings paired with prior research; there might be fewer smokers with high FVI because depressive symptoms are removed as an impediment to cessation. Further experimental research is warranted to test the efficacy of increased FVI as an adjunct to smoking cessation, with a possible mechanism of action being reduced depressive symptoms during quit attempts.
Groin wound infection after arterial surgery

Fifty‐six patients, 30 with superficial and 19 with deep groin wound infections, and seven with lymph fistulae with positive cultures within 30 days of arterial surgery, were identified after 661 operations (873 groins at risk) between September 1984 and August 1988. The commonest infecting organisms were Staphylococcus aureus, Pseudo‐monas aeruginosa and Proteus spp. In 33 patients the infection settled completely after treatment with culture specific antibiotics. These were given intravenously then orally for up to 6 weeks. Sixteen patients required debridement and excision of necrotic wound edges, including one who had an antibiotic infusion into the wound. Graft excision was performed in seven patients of whom five received an extra anatomic bypass. The need for graft excision was much greater (six versus one) for Dacron® and/or polytetrafluoroethylene than for vein. In two lymph fistulae sartorius transposition and wound resuture were used. All groins healed, though three extremities were ischaemic following occlusion of the bypass. There were two deaths, one from myocardial infarction and one from pulmonary embolism and no major amputations. These results suggest that most infective groin problems may be successfully managed conservatively and that radical graft excision is only necessary for a few intractable cases.
The mammalian G protein rhoC is ADP‐ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

Clostridium botulinum C3 is a recently discovered exoenzyme that ADP‐ribosylates a eukaryotic GTP‐binding protein of the ras superfamily. We show now that the bacterially‐expressed product of the human rhoC gene is ADP‐ribosylated by C3 and corresponds in size, charge and behavior to the dominant C3 substrate of eukaryotic cells. C3 treatment of Vero cells results in the disappearance of microfilaments and in actinomorphic shape changes without any apparent direct effect upon actin. Thus the ADP‐ribosylation of a rho protein seems to be responsible for microfilament disassembly and we infer that the unmodified form of a rho protein may be involved in cytoskeletal control.