Miracle-dz/UniFAR-FTUs huggingface dataset:
How Finnair Socialized Customers for Service Co-Creation with Social Media

Open co-creation enables a firm to develop new solutions by working closely with online communities that include customers and other interested parties. Co-creation requires a socialization strategy that ensures community members identify with the firm’s image and engage in dialogs that are aligned with company and customer needs. There are two types of tactics for a customer socialization strategy—institutionalized, where control of the interaction remains primarily with the firm (push mode), and individualized, where by and large the customer is in charge (pull mode).
Basal Ganglia Infarct in an Infant with Sickle Cell Disease - A Rare

Cerebrovascular accidents are common in elderly people, but rare in children. The stroke developing due to basal ganglion infarct in an infant with sickle cell disease (homozygous) is extremely rare. To the best of our knowledge, not a single case has been repoted till date. We are reporting a 10 months old infant developing stroke after a mild fall. The child was diagnosed of lacunar basal ganglion infarct in MRI. No abnormality was detected in routine hematological check-up and coagulation profile. But, sickling test was positive and confirmed of Sickle Cell Disease (SCD) in Hemoglobin electrophoresis (capillary zone). Although extremely rare, while dealing with stroke in infants and children, possibility of SCD should always be kept in mind.
Msx1creERT2 knock‐In allele: A useful tool to target embryonic and adult cardiac valves

Summary: Heart valve development begins with the endothelial‐to‐mesenchymal transition (EMT) of endocardial cells. Although lineage studies have demonstrated contributions from cardiac neural crest and epicardium to semilunar and atrioventricular (AV) valve formation, respectively, most valve mesenchyme derives from the endocardial EMT. Specific Cre mouse lines for fate‐mapping analyses of valve endocardial cells are limited. Msx1 displayed expression in AV canal endocardium and cushion mesenchyme between E9.5 and E11.5, when EMT is underway. Additionally, previous studies have demonstrated that deletion of Msx1 and its paralog Msx2 results in hypoplastic AV cushions and impaired endocardial signaling. A knock‐in tamoxifen‐inducible Cre line was recently generated (Msx1CreERT2) and characterized during embryonic development and after birth, and was shown to recapitulate the endogenous Msx1 expression pattern. Here, we further analyze this knock‐in allele and track the Msx1‐expressing cells and their descendants during cardiac development with a particular focus on their contribution to the valves and their precursors. Thus, Msx1CreERT2 mice represent a useful model for lineage tracing and conditional gene manipulation of endocardial and mesenchymal cushion cells essential to understand mechanisms of valve development and remodeling. genesis 53:337–345, 2015. © 2015 Wiley Periodicals, Inc.
Can the US examination for lower extremity deep venous thrombosis be abbreviated? A prospective study of 755 examinations.

PURPOSE To determine if the ultrasound (US) survey of the lower extremity for deep venous thrombosis (DVT) can be curtailed without compromising diagnostic efficacy. MATERIALS AND METHODS The authors performed 755 US examinations in 721 patients (1,024 lower extremities) referred for suspicion of lower extremity DVT. The full lengths of the deep veins were studied, and findings were categorized at five locations: common femoral vein (CFV), proximal superficial femoral vein (CFV), mid-SFV, distal SFV, and popliteal vein (PV). RESULTS Acute thrombus was seen in one or more veins in 131 (17.4%) of the 755 examinations. DVT isolated to a single vein was seen in 28 (21.4%) of the 131 positive examinations: DVT was limited to the CFV in eight studies (61%), to the SFV in six studies (4.6%), and to the PV in 14 studies (10.7%). CONCLUSIONS DVT limited to a single vein occurs with sufficient frequency that the US screening survey cannot be abbreviated without loss of diagnostic efficacy.
New federal guidelines for physician-pharmaceutical industry relations: the politics of policy formation.

In October 2002 the federal government issued a draft "Compliance Program Guidance for Pharmaceutical Manufacturers. " The draft Guidance questioned the legality of many arrangements heretofore left to the discretion of physicians and drug companies, including industry-funded educational and research grants, consultantcies, and gifts. Medical organizations and drug manufacturers proposed major revisions to the draft, arguing that current practices were in everyone's best interest. To evaluate the impact of their responses, we compare the draft, the changes requested by industry and organized medicine, and the final Guidance document (issued in April 2003). We also explore the implications--some intended, others unanticipated--of the final document.
Relaxation of mechanical tolerances in phase retrieval antenna metrology

The sensitivity of phase retrieval antenna near-field/far-field predictions to scanning errors is investigated. It is shown that phase retrieval is considerably more tolerant to planarity errors than conventional near-field/far-fleld methods and in this respect is superior for mm and sub-mm wave antennas. Similar improvements apply to cylindrical scanning but the effects are not so important since the radial distance variations will be small. Errors in (x,y) and (¿,z) produce similar errors in both phase retrieval and conventional near-field/far-field predictions.
Prevalence and Risk of Hypertension in Renal Disease – Data from the Czech Registry of Renal Biopsies

Background/Aims: We intended to compare the risk and prevalence of hypertension in patients undergoing renal biopsy with those of the general population and to investigate the possible effects of various independent factors (age, sex and degree of renal insufficiency) on the prevalence of hypertension. Methods: Data obtained within the Czech Registry of Renal Biopsies over an 8-year period (1995–2002) were statistically evaluated and compared with those of the general population obtained within the Post-MONICA Study conducted in 2000/2001. Results:Hypertension was present in 1,839 out of a total of 3,601 renal patients (51.1%). The risk of hypertension in the patients with renal disease was increased in all age groups compared with the general population (OR = 1.3–5.3). The prevalence of hypertension increased significantly with age, serum creatinine and proteinuria (p < 0.001). Male sex was identified as an independent risk factor for the presence of hypertension (p < 0.01). Sex, age and glomerular filtration rate were shown to be more important determinants of the risk of hypertension than the underlying biopsy-proven diagnosis itself. Conclusion: Hypertension occurs as a common complication of renal disease, even in its early stages, and irrespective of the histological finding.
Smart Spaces: Indoor Wireless Location Management System

Determining the location of objects or people in a smart space is one of the prerequisites enabling smart applications. The ideal location system makes use of existing infrastructure such as wireless LAN or cellular communication systems. However, in indoor environment typical wireless LAN systems do not provide sufficient accuracy for many smart applications and such as WLAN based location system needs to be enhanced. This paper involves proposal of a heterogeneous location system based on a combination of IEEE 802.11 WLAN and a sensor network based ultra wideband radar system. The proposed system provides greater accuracy than other proposed systems and provides the added advantage that the sensor network can be utilized for other ubiquitous computing applications.
Review of hand gesture recognition study and application

Human-computer interaction is an essential part of most people's daily life. The traditional human-computer interaction mode from the original keyboard to the current mouse, joystick, and wireless input devices, greatly facilitates the interaction between people and computers and makes it easier for people to operate the computer and improve work efficiency. However, this kind of interaction mode cannot completely meet the demands of human-computer interaction due to the dependence on additional input hardware devices. Hand gesture can be defined as a variety of gestures or movements produced by hands or arms combined, it is always capable of expressing a signer’s intention, so it can act as a means of natural communication between human and machine. Studies on hand gesture recognition is very important for the development of new human-centered human-computer interaction. This paper reviewed the current study status and application of gesture recognition aiming to summarize the commonly used hand gesture recognition methods, analysis their strength and weak points, and list the challenging problems in current research of hand gesture recognition.
Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn’s disease

Objectives: Autologous haematopoietic stem cell transplantation (HSCT) with CD34+ cell selection has recently been used in the treatment of refractory Crohn’s disease, showing good safety and promising efficacy. We investigated the safety and efficacy of HSCT with unselected peripheral blood stem cells (PBSCs) in moderate–severe refractory Crohn’s disease. Patients: Four patients (three male, one female; age range 26–45 years) with active moderate–severe Crohn’s disease (median Crohn’s Disease Activity Index (CDAI) 319, range 272–345), refractory or intolerant to multiple drugs including infliximab, were enrolled. Interventions: Unselected PBSCs were collected after mobilisation with cyclophosphamide (CTX) 1.5 g/m2 and granulocyte-colony stimulating factor (G-CSF) 10 μg/kg. The conditioning regimen included CTX 50 mg/kg on days −5 to −2 and rabbit anti-thymocyte globulin (ATG) 2.5 mg/kg on days −4 to −2. Main outcome measures: Primary endpoints were toxicity and clinical remission (CDAI<150) at 3 months. Secondary endpoints were clinical and endoscopic response at 3 months and toxicity, clinical and endoscopic remission at 12 months. Results: No improvement or slight deterioration was observed following mobilisation (median CDAI 339, range 258–404). At the third month, the primary endpoint of clinical remission was achieved in all patients, with a median CDAI of 91 (range 56–102), and complete endoscopic remission was achieved in 2/3 patients. After a median follow-up of 16.5 months, 3/4 patients maintained both clinical and endoscopic remission, despite withdrawal of all drugs, and complete fistula closure was observed in all affected patients. No deaths or life-threatening infection occurred. Unexpected adverse events included a perianal abscess after mobilisation in one patient, pleural and pericardial effusions in another and BK virus-related macrohaematuria in another, all rapidly resolved with conservative treatment. Conclusion: Autologous HSCT with unselected PBSC appears to be safe and can induce and maintain remission in previously refractory Crohn’s disease patients.
Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides

We report on the properties of a temperature-sensitive mutant produced by transfection of cells with intact DNA and a specific DNA fragment mutagenized with low levels of hydroxylamine. The plating efficiency of the mutant at 39 degrees C relative to that at 33.5 degrees C was 5 X 10(-6). The pattern of polypeptides produced at the nonpermissive temperature was similar to that seen with wild-type virus in infected cells treated with inhibitory concentrations of phosphonoacetic acid in that alpha and beta polypeptides were produced, whereas most gamma polypeptides were either reduced or absent. Consistently, the mutant did not make viral DNA, although temperature sensitivity of the viral DNA polymerase could not be demonstrated. Marker rescue studies with herpes simplex virus type 2 (HSV-2) DNA mapped the mutant in the L component within map positions 0.385 and 0.402 in the prototype (P) arrangement of the HSV-1 genome. Analysis of the recombinants permitted the mapping of the genes specifying infected cell polypeptides 36, 35, 37, 19.5, 11, 8, 2, 43, and 44, but only the infected cell polypeptide 8 of HSV-2 was consistently made by all recombinants containing demonstrable HSV-2 sequences. Marker rescue studies with cloned HSV-1 DNA fragments mapped the temperature-sensitive lesion within less than 10(3) base pairs between 0.383 and 0.388 map units. Translation of the RNA hybridizing to cloned HSV-1 DNA, encompassing the smallest region containing the mutation, revealed polypeptide 8 (128,000 molecular weight), which was previously identified as a beta polypeptide with high affinity for viral DNA, and a polypeptide (25,000 molecular weight) not previously identified in lysates of labeled cells.
On Languages Accepted in Polynomial Time

The family NP (P) of languages accepted by nondeterministic (deterministic) Turing machines operating in polynomial time is distinct from many well-known families of languages defined by tape-bounded or time-bounded Turing machines. In particular, it is shown that NP (P) is not equal to the family of context-sensitive languages, the family of languages accepted by deterministic linear bounded automata, or the family of languages accepted by deterministic Turing machines operating within exponential time.
Anti-inflammatory and antinociceptive effect of Symphytum officinale root

The present work evaluated the anti-inflammatory and antinociceptive activity of a Symphytum officinale root extract standardized in rosmarinic acid. The anti-inflammatory effect of the hydro-glyceroalcoholic extract administered orally was assessed by the carrageenan-induced rat paw oedema method while the antinociceptive effect was determined by the acetic acid induced writhing test in mice and by Randall Selitto test in rats. Content in rosmarinic acid quantified by a HPLC-MS method was 74.77 μg/mL. In the carrageenaninduced rat paw oedema method administration of S. officinale extract (500 mg/kg, orally) reduced significantly and dose-dependently oedema by 55.6% at 1h after inflammation was induced. In the writhing test, S. officinale extract (500 mg/kg, orally) inhibited by 45.25% the abdominal constrictions induced by acetic acid in mice. In the Randall Selitto test in rats, the oral administration of S. officinale extract (500 mg/kg, orally) demonstrated a strong peripheral antinociceptive effect in the first two hours after administration increasing the pain threshold by 58%. Our study demonstrated significant anti-inflammatory and antinociceptive effects of S. officinale extract probably mediated by peripheral mechanisms which may justify the traditional use in the treatment of some inflammatory diseases.
Design, fiction and the medical humanities

This paper sets out to explore the similarities between the developing discipline of speculative and critical design (SCD) and science fiction, and their relevance to the medical humanities. SCD looks beyond ‘commercial design’ to consider what sort of things we should, or should not, be designing in order to create preferable futures. It does so by extrapolating from current social, economic, political and scientific knowledge, designing artefacts, experiences and scenarios which communicate futures and alternative realities in tangible ways. By first outlying the relevance of SCD to the medical humanities, through its ability to imagine and visualise preferable healthcare futures, the paper will then discuss several recent design projects which focus on current and future ethical issues raised by emerging biotechnology. Through these projects, the paper will look at SCD's ability to provoke, engage and critique science and society, while also critically reflecting on the limitations of the evolving design discipline. Through the paper it is hoped that there can be an increased understanding of SCD and its ambitions, as well as its limitations, in order for SCD to better approach issues relating to health and wellbeing, along with other difficult and challenging issues which will affect all us today and into the (sci-fi) future.
Uncertainty Decoding with Adaptive Sampling for Noise Robust DNN-Based Acoustic Modeling

Although deep neural network (DNN) based acoustic models have obtained remarkable results, the automatic speech recognition (ASR) performance still remains low in noise and reverberant conditions. To address this issue, a speech enhancement front-end is often used before recognition to reduce noise. However, the front-end cannot fully suppress noise and often introduces artifacts that are limiting the ASR performance improvement. Uncertainty decoding has been proposed to better interconnect the speech enhancement front-end and ASR back-end and mitigate the mismatch caused by residual noise and artifacts. By considering features as distributions instead of point estimates, the uncertainty decoding approach modifies the conventional decoding rules to account for the uncertainty emanating from the speech enhancement. Although the concept of uncertainty decoding has been investigated for DNN acoustic models recently, finding efficient ways to incorporate distribution of the enhanced features within a DNN acoustic model still requires further investigations. In this paper, we propose to parameterize the distribution of the enhanced feature and estimate the parameters by backpropagation using an unsupervised adaptation scheme. We demonstrate the effectiveness of the proposed approach on real audio data of the CHiME3 dataset.
Analyzing Algorithm of Multi-camera Multi-touch System for Educational Application

In this paper, a multi-touch analyzing algorithm is presented to meet the requirements of the educational application. The proposed algorithm is designed for the purpose of multi-camera, high efficiency and low CPU consumption, which includes background image accumulation, blob recognition, blob tracking, multi-camera collaborative process, data fusion and blob track post processing algorithm etc. The proposed algorithm is tested on different multi-touch platforms such as FTIR, DI and LLP with typical multi-touch educational software. Experimental result shows that the proposed algorithm adapts to the requirements of educational application.
Stat5B Shuttles Between Cytoplasm and Nucleus in a Cytokine-Dependent and -Independent Manner1

In response to cytokine stimuli, Stats are phosphorylated and translocated to the nucleus to activate target genes. Then, most are dephosphorylated and returned to the cytoplasm. Using Ba/F3 cells, we found that the nuclear export of Stat5B by cytokine depletion was inhibited by leptomycin B (LMB), a specific inhibitor of nuclear export receptor chromosome region maintenance 1. Interestingly, LMB treatment in the absence of cytokine led to the accumulation of Stat5B in the nucleus, suggesting that Stat5B shuttles between the nucleus and the cytoplasm as a monomer without cytokine stimulation. This notion is supported by the observation that LMB-induced accumulation of Stat5B in the nucleus was also observed with Stat5B having a mutated tyrosine 699, which is essential for dimer formation. Using a series of mutant Stat5Bs, we identified a part of the coiled coil domain to be a critical region for monomer nuclear import and a more N-terminal region to be critical for the cytokine stimulation dependent import of Stat5B. Taken together, we propose a model in which Stat5B shuttles between the nucleus and cytoplasm by two different mechanisms, one being a factor-independent constitutive shuttling by monomeric form, and the other, a factor stimulation-dependent one regulated by tyrosine phosphorylation and subsequent dimerization.
Advanced neointimal growth is not associated with a low risk of in-stent thrombus. Optical coherence tomographic findings after first-generation drug-eluting stent implantation.

BACKGROUND There is a hypothesis that advanced neointimal stent coverage may protect against stent thrombosis. In the present study, differences in neointimal growth and prevalence of in-stent thrombus between paclitaxel- and sirolimus-eluting stent (PES and SES) were evaluated by optical coherence tomography (OCT). METHODS AND RESULTS Follow-up angiographic and OCT examinations at approximately 6 months were performed for 40 patients (20 PES, 20 SES). Late loss was measured by quantitative coronary angiography. Neointimal hyperplasia (NIH) thickness on stent struts was measured by cross-sectional OCT images at 1 mm intervals. After measuring the NIH area in each cross-section, NIH volume was calculated as integral of NIH area within the stent. Late loss, NIH thickness, and NIH volume were greater for PES than for SES (0.42 +/-0.44 vs 0.13 +/-0.12 mm, 118 +/-141 vs 31 +/-39 mum, 53.2 +/-30.5 vs 24.3 +/-14.0 mm(3); P<0.05, respectively). In-stent thrombus was found more frequently in PES than in SES (50 vs 15%; P=0.02). CONCLUSIONS Although the degree of neointimal growth in PES was generally greater, in-stent thrombus was more common compared with SES. Presence of thrombus in first-generation drug-eluting stents was not related to advanced neointimal growth.
Finite temperature vacancy formation thermodynamics: local harmonic and quasiharmonic studies

The vacancy formation thermodynamics in six FCC metals Ag, Au, Cu, Ni, Pd and Pt are determined from atomistic simulations as a function of temperature. The investigation is performed using the embedded atom method interatomic potentials and the finite temperature properties are determined within the local harmonic and the quasiharmonic frameworks. The temperature dependence of the vacancy formation free energy, entropy, enthalpy and vacancy formation volume are determined. The authors find that the temperature dependence of the vacancy formation energy can make a significant contribution to the vacancy concentration at high temperatures. An additional goal of the study is to evaluate the accuracy of the local harmonic method under circumstances in which the excess entropy associated with the formation of a defect is very small. The data demonstrate that while the errors associated with determining the vacancy formation entropy in the local harmonic model are large, a simple extension to the local harmonic method yields thermodynamic properties comparable to that obtained in the quasiharmonic model, but with much higher computational efficiency.