Miracle-dz/UniFAR-FTUs huggingface dataset:
1,25-Dihydroxyvitamin D3 Suppresses Renin Gene Transcription by Blocking the Activity of the Cyclic AMP Response Element in the Renin Gene Promoter*

We have shown that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) down-regulates renin expression. To explore the molecular mechanism, we analyzed the mouse Ren-1c gene promoter by luciferase reporter assays. Deletion analysis revealed two DNA fragments from –2725 to –2647 (distal fragment) and from –117 to +6 (proximal fragment) that are sufficient to mediate the repression. Mutation of the cAMP response element (CRE) in the distal fragment blunted forskolin stimulation as well as 1,25(OH)2D3 inhibition of the transcriptional activity, suggesting the involvement of CRE in 1,25(OH)2D3-induced suppression. EMSA revealed that 1,25(OH)2D3 markedly inhibited nuclear protein binding to the CRE in the promoter. ChIP and GST pull-down assays demonstrated that liganded VDR blocked the binding of CREB to the CRE by directly interacting with CREB with the ligand-binding domain, and the VDR-mediated repression can be rescued by CREB, CBP, or p300 overexpression. These data indicate that 1,25(OH)2D3 suppresses renin gene expression at least in part by blocking the formation of CRE-CREB-CBP complex.
Attitudes of University Students Voters Towards Political Messages in Social Media

In recent years, social media has become one of the most important political marketing tools. The aim of the research is to determine how university students voting have attitudes towards political messages run across several different social media channels. Undergraduate students in Tekirdag Central Campus of Namik Kemal University are generating the population of the study. In this research, sample was not taken. Questionnaire form was used as data collecting tool. Data obtained through questionnaire forms were presented as descriptive statistics frequency, percentage, mean, standard deviation. For differences between group means, T-test and One-way ANOVA were implemented. It was concluded that messages with political content in social media had intensifier effects on present preferences of university student voters and had directive effects on indecisive students. Twitter users had more negative attitudes towards messages with political content in social media.
Delayed sleep phase syndrome: A placebo‐controlled cross‐over study on the effects of melatonin administered five hours before the individual dim light melatonin onset

In a double‐blind placebo‐controlled cross‐over study, 30 patients with Delayed Sleep Phase Syndrome (DSPS) were included, of whom 25 finished the study. Melatonin 5 mg was administered during two weeks in a double‐blind setting and two weeks in an open setting successively or interrupted by two weeks of placebo. The study's impact was assessed by measurements of the 24‐h curves of endogenous melatonin production and rectal temperature (n=14), polysomnography (n=22), actigraphy (n=13), sleep log (n=22), and subjective sleep quality (n=25). Mean dim light melatonin onset (DLMO) (±SD), before treatment, occurred at 23.17 hours (±138 min). Melatonin was administered five hours before the individual DLMO. After treatment, the onset of the nocturnal melatonin profile was significantly advanced by approximately 1.5 hour. Body temperature trough did not advance significantly. During melatonin use, actigraphy showed a significant advance of sleep onset and polysomnography, a significant decreased sleep latency. Sleep architecture was not influenced. During melatonin treatment patients felt significantly more refreshed in the morning. These results show that analysis of DLMO of patients suffering from DSPS is important both for diagnosis and therapy. These results are discussed in terms of the biochemistry of the pineal.
Timing the therapeutic window of opportunity in early rheumatoid arthritis: proposal for definitions of disease duration in clinical trials

The effects of treatment in early rheumatoid arthritis (RA) and the consequences of delayed therapy represent important areas for research. The concept of a ‘window of opportunity’ is now well established and considerable attention has been paid to when it might close. However, in order to study how long the window of opportunity lasts, the timing of its opening must be precisely defined. An analysis of definitions of ‘onset’ in clinical studies reveals imprecision and heterogeneity, making accurate assessment of this important concept of the ‘window of opportunity’ very difficult. In this paper we propose that, in clinical trials in early RA, data on durations since onset of symptoms and onset of joint swelling as well as disease duration based on fulfilment of classification criteria should be routinely presented.
Toward a Future with Human Hands-Like Haptics: A Universal Framework for Interfacing Existing and Future Multipoint Haptic Devices

In this article, we propose a universal MPH (multipoint haptics) framework with its underlying abstract MPH model, which support existing and future multimanual, multifinger haptic systems, rendering both kinesthetic and tactile feedbacks. The abstract MPH model defines multiple interaction models hierarchically, which can be helpful in the definition of hardware scope for customized haptic systems. The framework defines the primitive components and operations, which can be adopted by various drivers and SDK configurations for advanced MPH applications.
Effects of Newer Atypical Antipsychotics on Autonomic Neurocardiac Function: A Comparison Between Amisulpride, Olanzapine, Sertindole, and Clozapine

As part of a prospective clinical study investigating the effects of atypical neuroleptics on autonomic neurocardiac function (ANF), serial standardized recordings of conventional electrocardiograms and computer-calculated measurements of 5-minute resting heart rate variability (HRV) were obtained from 51 medication-free inpatients with schizophrenia (DSM-III-R-diagnosed) before and after an average of 14.1 days of treatment with amisulpride 400 mg/day (N = 12), olanzapine 20 mg/day (N = 13), sertindole 12 mg/day (N = 13), or clozapine 100 mg/day (N = 13). Reference values for the HRV data were obtained from a large group of well-matched healthy controls (N = 70). The most important findings were the following: (1) clozapine, olanzapine, and sertindole all prolonged mean frequency-corrected QTc times, which, in the case of sertindole, proved to be significant (Wilcoxon test p <0.05); (2) sertindole and clozapine significantly increased the mean resting heart rate; and (3) only clozapine significantly reduced the parasympathetic resting tone. The results of the HRV studies are discussed considering the in vitro receptor profiles of the atypical neuroleptics under study. Potential implications for the cardiac safety and tolerance of these drugs are also discussed.
Tyrosine kinases and synaptic transmission

This review will examine the implications, for synaptic transmission, of protein tyrosine kinase (PTK) activity. The focus will be on non-receptor PTKs, their distribution in the CNS, the biological significance of some likely substrates and the means by which PTK activity might be regulated. The extensive study of cell growth and differentiation has revealed two categories of PTKs; those which are an integral component of receptors, such as growth factor receptors, and those which are not linked to specific receptors, of which the best known examples are the src family. Although the role of non-receptor PTKs in mature neurones is poorly understood, there is increasing evidence implicating them in neuronal signal transmission on a par with other protein kinases (see review by Moss & Smart, 1996). The brain contains high levels of PTK activity (Hiranoet al., 1988) and antibody staining for phosphotyrosine demonstrates that endogenous substrates are present. Overall levels of tyrosine phosphorylation show developmental changes and also regional variations within the brain (Cudmore & Gurd, 1991) indicating that this is not a static phenomenon, but may subserve some physiological role beyond a mere housekeeping function.
Broad‐based proteomic strategies: a practical guide to proteomics and functional screening

Proteomics, the study of the proteome (the collection of all the proteins expressed from the genome in all isoforms, polymorphisms and post‐translational modifications), is a rapidly developing field in which there are numerous new and often expensive technologies, making it imperative to use the most appropriate technology for the biological system and hypothesis being addressed. This review provides some guidelines on approaching a broad‐based proteomics project, including strategies on refining hypotheses, choosing models and proteomic approaches with an emphasis on aspects of sample complexity (including abundance and protein characteristics), and separation technologies and their respective strengths and weaknesses. Finally, issues related to quantification, mass spectrometry and informatics strategies are discussed. The goal of this review is therefore twofold: the first section provides a brief outline of proteomic technologies, specifically with respect to their applications to broad‐based proteomic approaches, and the second part provides more details about the application of these technologies in typical scenarios dealing with physiological and pathological processes. Proteomics at its best is the integration of carefully planned research and complementary techniques with the advantages of powerful discovery technologies that has the potential to make substantial contributions to the understanding of disease and disease processes.
Collaboration Game Theory Heterogeneous Network Resource Allocation Algorithm

With the continuous improvement of the transmission rate and the quality of wireless communications services, the need for a wireless communication network structure to adjust. The traditional rules of cellular networks no longer meet the high-density, large number of people for high-speed data transmission. Heterogeneous network can solve the problem of network coverage and network-efficient transport, but because of the heterogeneous network dense arrangement of the network, so the introduction of a number of inter-cell interference, especially at the edge of the cell. To solve this problem, we use collaborative tools of game theory, to be distributed among the power cells to determine the coverage of each pico cell. But the need to optimize collaboration between cells, select the number and scope of the coordinated cell. Simulation results show that the proposed algorithm can effectively improve the transmission rate of the system, eliminating the interference between cells.
An Outer Bound for the Vector Gaussian CEO Problem

We study the vector Gaussian CEO problem, where there are arbitrary number of agents, each having a noisy observation of a vector Gaussian source. The goal of the agents is to describe the source to a central unit, which wants to reconstruct the source within a given distortion. The rate-distortion region of the vector Gaussian CEO problem is unknown in general. Here, we provide an outer bound for the rate-distortion region of the vector Gaussian CEO problem. We obtain our outer bound by evaluating an outer bound for the multiterminal source coding problem by means of a technique relying on the de Bruijn identity and properties of the Fisher information. Next, we investigate the tightness of our outer bound. Although our outer bound is tight for certain cases, we show that our outer bound does not provide the exact rate-distortion region in general. To this end, we provide an example and show that the rate-distortion region is strictly contained in our outer bound for this example.
Neuroanatomical target theory as a predictive model for radiation-induced cognitive decline

Objective: In a retrospective review to assess neuroanatomical targets of radiation-induced cognitive decline, dose volume histogram (DVH) analyses of specific brain regions of interest (ROI) are correlated to neurocognitive performance in 57 primary brain tumor survivors. Methods: Neurocognitive assessment at baseline included Trail Making Tests A/B, a modified Rey-Osterreith Complex Figure, California or Hopkins Verbal Learning Test, Digit Span, and Controlled Oral Word Association. DVH analysis was performed for multiple neuroanatomical targets considered to be involved in cognition. The %v10 (percent of ROI receiving 10 Gy), %v40, and %v60 were calculated for each ROI. Factor analysis was used to estimate global cognition based on a summary of performance on individual cognitive tests. Stepwise regression was used to determine which dose volume predicted performance on global factors and individual neurocognitive tests for each ROI. Results: Regions that predicted global cognitive outcomes at doses <60 Gy included the corpus callosum, left frontal white matter, right temporal lobe, bilateral hippocampi, subventricular zone, and cerebellum. Regions of adult neurogenesis primarily predicted cognition at %v40 except for the right hippocampus which predicted at %v10. Regions that did not predict global cognitive outcomes at any dose include total brain volume, frontal pole, anterior cingulate, right frontal white matter, and the right precentral gyrus. Conclusions: Modeling of radiation-induced cognitive decline using neuroanatomical target theory appears to be feasible. A prospective trial is necessary to validate these data.
Comparative analysis of different distortion reduction techniques for parametric loudspeaker based on self-demodulation of amplitude modulated ultrasound waves

A highly focused sound beam can be created from the nonlinear interaction of ultrasound waves by using a parametric loudspeaker. An audio signal is produced by the self-demodulation of amplitude modulated sound waves in air. Several preprocessing techniques have been discussed in previous literature to reduce distortion. A comparative analysis of these preprocessing techniques is presented in this paper. Some preceding preprocessing techniques rely on equalization and square-rooting. Newer techniques, instead of using only simple AM, have an additional AM signal with a carrier that is orthogonal to the original one. It will be clearly seen that the distortion of the modified AM is greatly reduced from the normal AM. Simulation results show the effectiveness of the preprocessing techniques.
Second Primary Neoplasms: A Clinico-Pathological Analysis from a Sub Himalayan Cancer Centre in India

Background: There is a lifetime risk of developing another de novo malignancy in diagnosed cancer patients. Detection of new primary has increased due to advances in both diagnostic and treatment modalities. This article aims to analyze the pattern of presentation of second primary neoplasm and to review the relevant literature. Materials and Methods: We analyzed patients presenting with histologically proven synchronous or metachronous second primaries from July 2011 to July 2016. Warren and Gate's criteria have been used to designate a case as second primary neoplasm. Various details such as age at diagnosis, sex, whether synchronous or metachronous, site, stage, histopathology, treatment were collected. Results: Over a period of 5 years total 40 cases were observed, out of which 13 were synchronous (33%) and 27 (67%) were metachronous. The median age at the diagnosis of primary malignancy was 65.5 years (range 27-84). Out of the 40 patients, 28 (70%) were males and 12 (30%) were females. The most common site of primary tumor was head and neck and genito-urinary, 11 cases each. Among the second malignancy most common site was gastrointestinal tract (11 cases), followed by genitourinary (10 cases) and lung (9 cases). Conclusion: The likelihood of diagnosis of second malignancy has increased with the advent of newer diagnostic modalities as well as increased compliance to follow up and progress in the management. Appearance of new signs and symptoms should raise a suspicion and early detection of the disease leads to appropriate management.
Comparison of Extramedullary Versus Intramedullary Referencing for Tibial Component Alignment in Total Ankle Arthroplasty

Background: The majority of total ankle arthroplasty (TAA) systems use extramedullary alignment guides for tibial component placement. However, at least 1 system offers intramedullary referencing. In total knee arthroplasty, studies suggest that tibial component placement is more accurate with intramedullary referencing. The purpose of this study was to compare the accuracy of extramedullary referencing with intramedullary referencing for tibial component placement in total ankle arthroplasty. Methods: The coronal and sagittal tibial component alignment was evaluated on the postoperative weight-bearing anteroposterior (AP) and lateral radiographs of 236 consecutive fixed-bearing TAAs. Radiographs were measured blindly by 2 investigators. The postoperative alignment of the prosthesis was compared with the surgeon’s intended alignment in both planes. The accuracy of tibial component alignment was compared between the extramedullary and intramedullary referencing techniques using unpaired t tests. Interrater and intrarater reliabilities were assessed with intraclass correlation coefficients (ICCs). Results: Eighty-three tibial components placed with an extramedullary referencing technique were compared with 153 implants placed with an intramedullary referencing technique. The accuracy of the extramedullary referencing was within a mean of 1.5 ± 1.4 degrees and 4.1 ± 2.9 degrees in the coronal and sagittal planes, respectively. The accuracy of intramedullary referencing was within a mean of 1.4 ± 1.1 degrees and 2.5 ± 1.8 degrees in the coronal and sagittal planes, respectively. There was a significant difference (P < .001) between the 2 techniques with respect to the sagittal plane alignment. Interrater ICCs for coronal and sagittal alignment were high (0.81 and 0.94, respectively). Intrarater ICCs for coronal and sagittal alignment were high for both investigators. Conclusions: Initial sagittal plane tibial component alignment was notably more accurate when intramedullary referencing was used. Further studies are needed to determine the effect of this difference on clinical outcomes and long-term survivability of the implants. Level of Evidence: Level III, retrospective comparative study.
Habitual physical activity of Senegalese adolescent girls under different working conditions, as assessed by a questionnaire and movement registration

Summary. Objective: The aim of this study was to measure habitual physical activity in a group of Sereer adolescent females from Senegal. The hypothesis tested was that physical activity levels of adolescent Senegalese girls differ according to location and living conditions and may have a negative impact on growth and nutritional status. Design: Studies of physical activity within the framework of a longitudinal study of growth during puberty. Methods: All the adolescents were born and had been raised in the same rural communities, but some worked as maids in the cities during the dry season (migrants) while the others remained in the villages all year round in order to help their families in daily domestic and agricultural tasks (non-migrants). The study was undertaken in both rural and urban settings on a subsample of 40 migrant and 40 non-migrant girls aged 13.4-15.3, drawn from a cohort of 406 adolescents followed up since 1995. Nutritional status was estimated from anthropometric measurements; sexual maturation was based on stage of breast development and occurrence of menarche. Intensity and patterns of physical activity were derived from movement registration by accelerometry for a 3-day period. The nature and frequency of daily tasks were evaluated by questionnaires. Results: As a whole, the adolescents studied here were smaller, thinner and less mature than girls of the same age from developed countries. Migrants weighed 3.5kg more than nonmigrants and had more muscularity and a thicker fat subcutaneous layer. The day-to-day reliability of accelerometry counts was excellent (intraclass correlation coefficient: 0.90, 95% CI: 0.85-0.93). Mean daily (24h) physical activity counts were higher for migrants than for non-migrants. Migrants spent more time engaged in moderate to heavy activity than did non-migrants (9.3h/24h versus 6.1 h/24h). Non-migrants slept or were inactive for a longer period than migrants (7.6 h/24h versus 6.3h/24h). They also rested for a longer period of the day (2.1h/24h versus 0.8h/24h). When examining the influence of maturational status on physical activity, there was a clear difference between the two groups: the less mature migrants were more active, whereas the reverse was true in villages, where girls at the end of puberty reached higher intensity indices. Conclusions and implications: In both situations, the activity level was high. The nutritional status of migrants was better despite a heavier work load. Differences could be explained by better living conditions and food intake in cities.
Efficacy of Quetiapine for Impulsivity and Affective Symptoms in Borderline Personality Disorder

Data on the efficacy of quetiapine in borderline personality disorder (BPD) are still scarce. We aimed to investigate the efficacy of quetiapine for impulsivity and a broad range of affective symptoms in BPD. In this 12-week open-label study, we included individuals with BPD who presented to psychiatric in- and outpatient services. After a gradual titration of quetiapine, a flexible dose (range, 100-800 mg) was administered. The main outcome measures consisted of the scores on patient-rated questionnaires (Barratt Impulsiveness Scale, Buss-Durkee Hostility Inventory, Affective Lability Scale, Spielberger State and Trait Anxiety Inventory, Spielberger State and Trait Anger Inventory, and Beck Depression Inventory) and on neurocognitive tasks related to impulsivity (Stroop Color Word Task and IOWA Gambling Task). A mixed linear model, correcting for age, sex, antidepressant use, and weeks in psychotherapy, was applied. Forty-one patients (34 females and 7 males; mean [SD] age, 27.0 [9.0] years) were enrolled in the study, 32 of which completed the trial. Patients' scores decreased significantly (mean [SD] difference; P value) on the Barratt Impulsiveness Scale (19.7 [2.0]; P < 0.0001), Buss-Durkee Hostility Inventory (11.5 [1.4]; P < 0.0001), Affective Lability Scale (0.75 [0.08]; P < 0.0001), Beck Depression Inventory (25.0 [1.7]; P < 0.0001), Spielberger State and Trait Anxiety Inventory state (19.9 [1.9]; P < 0.0001) and trait (20.8 [1.7]; P < 0.0001) subscale, and Spielberger State and Trait Anger Inventory state (7.3 [1.1]; P < 0.0001) and trait (10.1 [1.0]; P < 0.0001) subscale. In addition, patients showed significantly less inference on the Stroop Color Word Task and had more 'good choices' on the IOWA Gambling Task. These results suggest that quetiapine may be efficacious in the treatment of impulsivity and affective symptoms in BPD.
Performance Analysis of Back propagation Network Model for Personalized Recommender System

A real world challenging task of an e-commerce application is to identify the needs of the active users based on user navigation patterns. Online navigation patterns are grown every day and extracting business intelligence is a challenging one. There are various personalized recommender systems have been proposed in the literature. In this paper we propose and analyse the performance of back propagation neural network model for personalized recommender system for better quality in terms of accuracy. The performance of an algorithm has been tested with different parameters with real world dataset for the performance benchmark.