Miracle-dz/UniFAR-FTUs huggingface dataset:
Improved random sampling consensus algorithm for vision navigation of intelligent harvester robot

Purpose Focusing on the problem that the visual detection algorithm of navigation path line in intelligent harvester robot is susceptible to interference and low accuracy, a navigation path detection algorithm based on improved random sampling consensus is proposed. Design/methodology/approach First, inverse perspective mapping was applied to the original images of rice or wheat to restore the three-dimensional spatial geometric relationship between rice or wheat rows. Second, set the target region and enhance the image to highlight the difference between harvested and unharvested rice or wheat regions. Median filter is used to remove the intercrop gap interference and improve the anti-interference ability of rice or wheat image segmentation. The third step is to apply the method of maximum variance to thresholding the rice or wheat images in the operation area. The image is further segmented with the single-point region growth, and the harvesting boundary corner is detected to improve the accuracy of the harvesting boundary recognition. Finally, fitting the harvesting boundary corner point as the navigation path line improves the real-time performance of crop image processing. Findings The experimental results demonstrate that the improved random sampling consensus with an average success rate of 94.6% has higher reliability than the least square method, probabilistic Hough and traditional random sampling consensus detection. It can extract the navigation line of the intelligent combine robot in real time at an average speed of 57.1 ms/frame. Originality/value In the precision agriculture technology, the accurate identification of the navigation path of the intelligent combine robot is the key to realize accurate positioning. In the vision navigation system of harvester, the extraction of navigation line is its core and key, which determines the speed and precision of navigation.
Highly active and thermally stable single-atom catalysts for high-temperature electrochemical devices

Single-atom catalysts provide unique catalytic properties and maximize the atom utilization efficiency. While utilizing them at elevated temperatures is highly desirable, their operating temperature is usually kept below 300 °C to prevent isolated atoms from agglomerating. Moreover, their applications in high-temperature electrochemical devices have been hindered by the lack of suitable processing techniques for catalyst loading. Herein, we report single-atom Pt/ceria nanocatalysts that are highly active and thermally stable in solid oxide cells (SOCs) operating at 600–800 °C. Our urea-based chemical solution process creates strong Pt–O–Ce interactions that securely anchor isolated Pt atoms to the surface of ceria nanoparticles and suppress their high-temperature migration. These single-atom Pt/ceria nanocatalysts are loaded in the oxide fuel electrode of a SOC via an in situ synthetic process, which reduces the polarization resistance from 28.2 to 0.82 Ohm cm2 at 600 °C. This electrode outperforms the state-of-the-art Ni-based fuel electrode by up to 10 times and delivers extremely high performance in full SOCs in fuel cell and electrolysis modes. Furthermore, it stably operates at 700 °C for over 500 h under realistic operating conditions. Our results provide guidance to resolve the critical issues for the practical use of single-atom catalysts in various industrial processes and accelerate the commercial development of next-generation high-temperature energy devices.
Future of immune checkpoint inhibitors: focus on tumor immune microenvironment

Immunotherapy has become a powerful clinical strategy in cancer treatment. Immune checkpoint inhibitors (ICIs) have opened a new era for cancer immunotherapy. Nowadays, the number of immunotherapy drug approvals has increased, with numerous treatment options in clinical and preclinical development. However, there remain some obstacles to improve the efficacy of ICIs further. The tumor immune microenvironment (TIME) consists of cancer cell, immune cells and cytokines, et cetera. The dynamics of TIME determine the efficacies of ICIs. Although the ICIs showed manageable toxicity, immune-related adverse effects (irAEs) are still unignorable for clinicians. Since some primary resistance mechanisms exist in TIME, ICIs can only show effects in individual cancer patients. Even for the patients who responded, acquired resistance will occur to neutralize the effect of ICIs. Understanding how to increase the response rates and overcome the resistance to various classes of ICIs is the key to improving clinical efficacy. Besides the novel ICIs in development, there are some approaches to establish combination therapies are underway to improve further the efficacies of ICIs in treating cancer patients. Here, we describe the complicated TIME and state quo of ICIs to prospect the future of ICIs in cancer treatment.
Untangling the Intracellular Mechanisms Underlying Toxicity of Drugs of Abuse: A Review of the Detrimental Effects of New Psychoactive Substances (NPS)

The recreational drug world is continuously evolving. Of note, the number of new psychoactive substances (NPS) reported for the first time has spread year on year. In 2016, 66 NPS were notified to the European early-warning system [1], reflecting the fast pace at which new drugs are introduced onto the market (over one per week). By the end of 2016, the European authorities were monitoring more than 620 NPS, compared with 350 in 2013 [1]. This fast-paced surge embodies a major challenge for (inter)national policy-makers due to the inefficient monitoring techniques, relevant social and lifethreatening impact, and inadequate response by health care providers.
The Superior Responsivity Enhancement of Thin-Film Ge Photodetectors by AuNP Coatings

We have tried to improve the responsivity of germanium-based thin-film photodetectors. It has been shown that applying a mechanical strain to the detector led to a 46.6% enhancement on the 1550 nm detection. This improvement is better than the 1310 nm case, because the bandgap shrinkage is more beneficial to the small-energy photon detection. The AuNP coating is even more attractive for responsivity enhancement of thin-film germanium (Ge) detectors. The responsivity enhancement due to the AuNP deposition is as high as 89% and 47%, for the 1310 nm and 1550 nm detections, respectively. To the best of our knowledge, this is the best responsivity enhancement for the thin-film Ge detectors reported to date.
Impacts of Low Self-control and Opportunity Structure on Cyberbullying Developmental Trajectories: Using a Latent Class Growth Analysis

This study tested self-control and opportunities theories to examine cyberbullying developmental trajectories through the estimation of a latent class growth analysis. Data from a 6-year longitudinal study of middle- and high-school students from South Korea were analyzed to examine if there are unique growth trajectories for cyberbullying perpetration when accounting for low self-control and opportunity factors. Results suggest that there are three distinct subgroups: (1) a normative trajectory group, (2) an increasing and late-peak group, and (3) an early onset and decreasing group. Low self-control was found to be significantly associated with early onset/decreasing cyberbullying. Opportunity to utilize cyberspace was significantly related with increasing/late peak cyberbullying but did not significantly mediate the effect of low self-control on class membership.
Plurals in Kaiowá and the case for obligatory implicatures

El enfoque de este articulo es la marcacion nominal opcional de numero en Kaiowa (Tupi-Guarani), expresada por la afijacion, en posicion post-nominal, de -kuera, un elemento que, segun defendemos, es un morfema que pertenece al sistema central de concordancia de numero de la lengua. Con base en el examen de datos linguisticos originales, demostramos la amplia ocurrencia de ese morfema en la lengua, que no esta restringido a contextos definidos, siendo tambien frecuente en contextos genericos indefinidos y con nombres que denotan especie. Ademas, notamos en un analisis preliminar que -kuera tambien puede funcionar como un morfema asociativo plural. Desde una perspectiva teorica formal, nuestro objetivo es extender a los hechos de Kaiowa una propuesta que se ocupa de la lectura “mas de uno” / “al menos dos”, expresada por la marcacion manifiesta del marcador de plural, como derivada de una implicatura (cf. SPECTOR 2007). Dicha propuesta requiere que se tomen en cuenta las alternativas (cf. FĂLĂUŞ 2013) que se activen semanticamente, pero que no se realicen morfologicamente. Asi, aunque la funcion singular no esta disponible en la morfologia de la lengua, puede activarse en la semantica como alternativa a uma construccion en la que -kuera esta presente. Argumentamos, por lo tanto, que ese morfema opcional funciona en la lengua como un “activador de alternativas” y, una vez que se activa una alternativa, la implicatura escalar se vuelve obligatoria (cf. CHIERCHIA 2006). Las dos lecturas en competencia, es decir, de plural vs. singular, constituyen el conjunto de alternativas escalares que se pueden formalizar como kueraALT = {lP: *P = P.P, lP: AT(P) = P.P}
Roles for the Cohibin Complex and its Associated Factors in the Maintenance of Several Silent Chromatin Domains in S. cerevisiae

In Saccharomyces cerevisiae, the telomeres and rDNA repeats are repetitive sil ent chromatin domains that are tightly regulated to maintain sile ncing and genome stability. Disruption of the Cohibin complex, which maintains rDNA silencing and stability, also abrogates telomere localization and silencing. Cohibin-deficient cells have decreased Sir2 localization at telomeres, and restoring telomeric Sir2 concentrations rescues th telomeric defects observed in Cohibindeficient cells. Genetic and molecular interactions suggest that Co hibin clusters telomeres to the nuclear envelope by binding inner nuclear membrane proteins. Futhermore, telomeric and rDNA sequences can form G-quadruplex structures. G-quad ruplexes are non-canonical DNA structures that have been linked to processes affecting chromo s e stability. Disruption of the Gquadruplex stabilizing protein Stm1, which also int eracts with Cohibin, increases rDNA stability without affecting silent chromatin formation. In al l, our findings have led to the discovery of new processes involved in the maintenance of repetitive silent chromatin domains that may be conserved across eukaryotes.
Palindromic nucleotide substitutions: A new software for pestivirus genotyping

The genus Pestivirus of the family Flaviviridae is represented by four established species; Bovine viral diarrhea virus 1 (BVDV-1), Bovine viral diarrhea virus 2 (BVDV-2), Border disease virus (BDV) and Classical swine fever virus (CSFV) and a tentative âGiraffeâ species. The palindromic nucleotide substitutions (PNS) in the 5â untranslated region (UTR) of Pestivirus RNA have been described as a new, simple and practical method for genotyping. The preparation of specific software was considered for an easy access of the users to the method. In the present study, the new software, named PNS, was prepared and the application on the genotyping procedures with the keys for Pestivirus identification as specific PNS at genus, species and genotype level, respectively, was evaluated on five hundred-tirty-four sequences. The software is freely available at www.pns-software.com
Galaxy–group (halo) alignments from SDSS DR7 and the ELUCID simulation

Based on galaxies from the Sloan Digital Sky Survey (SDSS) and subhalos in the corresponding reconstructed region from the constrained simulation of ELUCID, we study the alignment of central galaxies relative to their host groups in the group catalog, as well as the alignment relative to the corresponding subhalos in the ELUCID simulation. Galaxies in observation are matched to dark matter subhalos in the ELUCID simulation using a novel neighborhood abundance matching method. In observation, the major axes of galaxies are found to be preferentially aligned to the major axes of their host groups. There is a color dependence of galaxy-group alignment that red centrals have a stronger alignment along the major axes of their host groups than blue centrals. Combining galaxies in observation and subhalos in the ELUCID simulation, we also find that central galaxies have their major axes to be aligned to the major axes of their corresponding subhalos in the ELUCID simulation. We find that the galaxy-group and galaxy-subhalo alignment signals are stronger for galaxies in more massive halos. We find that the alignments between main subhalos and the SDSS matched subhalo systems in simulation are slightly stronger than the galaxy-group alignments in observation.
Antinociception and locomotor impairment induction by methanolic extract of Urtica dioica

Urtica dioica (UD), as anti-inflammatory and analgesic, has been used by people in Iran since long. The aerial parts of plant containing active materials have been utilized in the prostate proliferative disease. In the present studies Methanolic extracts of Urtica dioica were prepared by maceration. Antinociceptive activity of the extract was determined by hot plate and writhing tests in mice. Methanolic extract of UD at 50 and 100 mg/ kg could produce 59% and 98% writhing inhibition respectively. Morphine (5 mg/kg) with 91% writhing inhibition showed less analgesic activity than UD (100 mg/kg). Number of writhings was decreased by diclofenac (50 mg/kg) in magnitude of 78% that was less than UD at 100 mg/kg (p < 0.05). Methanolic extract, in all test doses (25-100 mg/kg) showed a dose dependent increase in pain threshold in hot plate thermal test which were significantly higher than control. LD50 of UD was obtained 300 mg/kg. UD extract at 150 mg/ kg showed significant impairment in mouse coordination in the rota rod test.
Voltage stability of solar dish-Stirling based autonomous DC microgrid using grey wolf optimised FOPID-controller

ABSTRACT This paper proposes the maiden application of a modern meta-heuristically optimised fractional order PID (FOPID) controller for ensuring the voltage stability of a DC microgrid system having PMDC generator coupled to a solar dish-Stirling engine. A significant cost reduction and efficiency enhancement can be achieved by the proposed topology. Popular meta-heuristic optimisation algorithms such as grey wolf optimiser (GWO), mine blast algorithm (MBA) and particle swarm optimisation (PSO) are adopted for tuning the gain constants of the controllers. The major focus of this article is to keep the common DC bus voltage of the microgrid at the desired steady-state value under varying load and varying solar insolation conditions. The results demonstrate the superior performance of the proposed controller.
Pharmacological Activity Of The Possessing New Atypical Neuroleptics 1-Phenyltetrahydroisoquinoline Structure

The first synthesized derivative of (3¢,4¢-methylenedioxyphenyl) -6,7-methylenedioxy-1,2,3,4tetrahydroquinoline, conventionally designated F-29, showed neuroleptic properties they have hypothermic, cataleptogenic, less pronounced suppression of motor activity, lack of central αadrenoand M-anticholinergic action and less toxic in severity comparable to the activity of a more close analogue of the neuroleptic haloperidol, which has motor and autonomic disorders [1], which F29 lacks.
Ice crystal growth of living onion epidermal cells as affected by freezing rates

ABSTRACT The entire crystallization process and the effect of freezing rates on the temperature of spontaneous freezing (TSF) of living onion epidermal cells were analysed in this study. The cells, stained with iodine at a concentration of 1%, were frozen at three different freezing rates, i.e. 2, 1.2, and 0.5°C/min, and were thawed at 5°C/min. The higher freezing rate caused a higher TSF. Moreover, this article presents a method for determining whether a cell is inactivated by a plasmolysis experiment. The results of plasmolysis showed that the formation of ice crystals did not cause fatal mechanical damages to the cells, even when the freezing rate was as slow as 0.1°C/min. Finally, this article also demonstrated the grey-scale changes that occurred in the cells, as evidenced by an image processing technique. This further highlighted the ice crystal growth process and showed the ice crystal content at different locations inside the cells.
Wheelchair Basketball Exercise Intensity in Youth

Children and youth with physical disabilities are at the greatest risk for inactivity, emphasizing the need for evidence-based activity options in recreation, rehabilitation, and post-rehabilitation settings. To determine if a wheelchair sport enabled youth participants to sustain moderate to vigorous physical activity (MVPA), the primary purpose of this study was to document exercise intensity of wheelchair basketball (WBB) among youth. The secondary purpose was to examine the influence of age, disability type, and training condition on intensity. Thirty-four youth with physical disabilities (MAge = 15.73 ± 2.57 yrs; MPlaying Experience = 4.32 ± 2.77 yrs) participated in three wheelchair basketball training sessions that included tactical drills (M = 113 min), and scrimmage (M = 57 min) training conditions. Percentage of maximum heart rate (HRMax), mean accelerometer vector counts per minute, and rate of perceived exertion (RPE) were assessed across 3 practices and collapsed into one training intensity score for each variable. Mean HRMax was 66±8% and mean accelerator vector counts were 6,055±1439 per minute, indicating that participants sustained MVPA during WBB training. Perceived effort, however, was distinct from the actual physical demand as mean RPE was 3.1±1.5. Age did not influence intensity scores but players who had a congenital or acquired spinal cord injury and were participating in scrimmage activity demonstrated higher exercise intensity. These findings support the ability of youth WBB players to sustain MVPA. This activity can be recommended as an evidence-based initiative in sport, rehabilitation or post-rehabilitation settings.
Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications

The inclusion of genetic data in large studies has enabled the discovery of genetic contributions to complex traits and their application in applied analyses including those using genetic risk scores (GRS) for the prediction of phenotypic variance. If genotypes show structure by location and coincident structure exists for the trait of interest, analyses can be biased. Having illustrated structure in an apparently homogeneous collection, we aimed to a) test for geographical stratification of genotypes in UK Biobank and b) assess whether stratification might induce bias in genetic association analysis. We found that single genetic variants are associated with birth location within UK Biobank and that geographic structure in genetic data could not be accounted for using routine adjustment for study centre and principal components (PCs) derived from genotype data. We found that GRS for complex traits do appear geographically structured and analysis using GRS can yield biased associations. We discuss the likely origins of these observations and potential implications for analysis within large-scale population based genetic studies.
SEMANTIC ANNOTATIONS ON HERITAGE MODELS: 2D/3D APPROACHES AND FUTURE RESEARCH CHALLENGES

Abstract. Research in the field of Cultural Heritage is increasingly moving towards the creation of digital information systems, in which the geometric representation of an artifact is linked to some external information, through meaningful tags. The process of attributing additional and structured information to various elements in a given digital model is customarily identified with the term semantic annotation; the added contextual information is associated, for instance, to analysis and conservation terms. Starting from the existing literature, aim of this work is to discuss how semantic annotations are used, in digital architectural heritage models, to link the geometrical representation of an artefact with knowledge-related information. Most consolidated methods -such as traditional mapping on 2D media, are compared with more recent approaches making the most of 3D representation. Reference is made, in particular, to Heritage-BIM techniques and to collaborative reality-based platforms, such as Aïoli (http://aioli.cloud). Potentialities and limits of the different solutions proposed in literature are critically discussed, also addressing future research challenges in Cultural Heritage application fields.
Trip Chaining Model with Classification and Optimization Parameters

In order to model the complex requirements of users travelling in an urban environment, the relevant parameters for creating activity chains have to be identified. In this study, travel related parameters were collected and grouped into two main types: classification parameters and optimization parameters. In the case of optimization parameters, further grouping was performed where general and comfort parameters were introduced. Additionally, the possible values and data sources of the parameters were identified. A utility function was created to take into account the optimization parameters and the weights. Weights related to comfort optimization parameters were aggregated to decrease the number of required settings by the users. Finally, the features of the proposed optimization algorithm are described. With the identified parameters, aggregated weights and elaborated utility function activity chains can be optimized for users with different requirements.
Fijación de la enzima acetilcolinesterasa (ACHE) en una matriz de poli(alcohol vinílico) (pva) utilizando benzoato de sodio como agente entrecruzante

espanolEn el presente trabajo se establece un protocolo para la inmovilizacion de la enzima acetilcolinesterasa (AChE), el cual puede ser utilizado para integrar dicho elemento biologico a un electrodo para la medicion de pesticidas. Se evalua una metodologia para la fijacion de la enzima en una matriz de poli(alcohol vinilico) (PVA), utilizando benzoato de sodio como agente entrecruzante. Esto se llevo a cabo por medio de la caracterizacion del proceso de entrecruzamiento del PVA, al irradiar con luz ultravioleta peliculas de este polimero a 5, 15, 30, 60, y 120 segundos. La formacion de la matriz se evidencio por medio de tecnicas como FTIR, DSC y TGA. De igual forma, se evaluo la actividad enzimatica de la enzima AChE soluble y atrapada en la matriz de PVA, por medio del valor de la velocidad inicial de reaccion. Se establecio que el tiempo optimo de entrecruzamiento del PVA es de 60 segundos de exposicion a luz ultravioleta. Se evidencia actividad enzimatica de la AChE atrapada en la matriz de PVA. EnglishIn this work, we have established a methodology for the immobilization of the acetyl cholin esterase (AChE) enzyme, which could be used for the development of biosensors to measure pesticides. It is evaluated a methodology to fix the acetyl cholin esterase (AChE) enzyme in a polyvinyl alcohol (PVA) matrix, using sodium benzoate as crosslinking agent. This was reached by irradiating PVA films for 5, 15, 30, 60, and 120 seconds with UV light and quantifying the crosslinking process. The matrix formation was studied using techniques as FITR, DSC and TGA. Moreover, the enzymatic activity of the soluble and trapped AChE enzyme was measured using the value of the initial reaction rate. The optimal time of crosslinking the PVA was found within 60 seconds of exposure to UV light. The enzymatic activity of the AChE trapped in the PVA matrix was verified.