Miracle-dz/UniFAR-FTUs huggingface dataset:
External Communication to Diffuse Science Gateways and Cyberinfrastructure as Innovations for Research with Big Data

In the era of big data, for science gateways (SG) and cyberinfrastructure (CI) projects to have the greatest impacts, the tools need to be widely adopted in the scientific community. However, diffusion activities (community engagement to spread the tools) are often an afterthought in some SG/CI projects. We warn against the fallacy of ‘If You Build It, They Will Come’. Projects could be intentional in promoting tool adoption. We identified five external communication practices based on an analysis of 20 interviews with administrators, developers, users, and outreach educators working in CI across the US. The practices include raising awareness of the innovations, engaging in educational outreach, building relationships with trust, networking with the community, and keeping a track record of persistent documentations. While exploratory in nature, the findings can be used as a guideline for project to promote SG/CI diffusion. The paper serves as evidence to justify a bigger budget from funder for diffusion activities to increase adoption and
Postcode prescribing in psychiatry

AIMS AND METHOD We aimed to examine variations in clozapine prescribing in all 12 NHS trusts with catchment area mental health services in one English county, over a 2-year period. We tested a series of hypotheses to explain the variation in prescribing of clozapine. RESULTS A 34-fold variation between trusts in rates of clozapine provision was found after adjusting for measures of local population need. This variation did not change over the 2 years examined. It was not explained by differences in resource level. CLINICAL IMPLICATIONS The evidence base is strong for the effectiveness and likely cost-effectiveness of clozapine in severe schizophrenia. Our data indicate that variations in evidence-based clinical practice at the provider level led to the wide variation in clozapine prescribing.
Differential Regional Stiffening of Sclera by Collagen Cross-linking

ABSTRACT Purpose: Corneal collagen cross-linking by ultraviolet light activation of riboflavin has been used clinically to enhance corneal stiffness. We sought to determine if cross-linking differentially affects scleral regions. Methods: Adjacent, parallel strips of sclera were cut from superolateral, superomedial, inferolateral, and inferomedial quadrants of posterior and equatorial sclera of 12 human cadaver eyes. One of each pair served as control while the other was cross-linked by immersion in 0.1% riboflavin and 365 nm exposure at 6 mW/cm2 irradiance for 30 min. Behavior of strips was characterized using a microtensile load cell. Preloaded strips were imaged using orthogonally mounted cameras and optical coherence tomography to determine specimen dimensions including cross-sectional area. Tension was measured during 0.1 mm/s constant rate elongation. Results: Young’s modulus (YM), the slope of the relationship relating tensile stress to strain, was calculated at 8% strain, and increased significantly after cross-linking (P < .001). In posterior sclera, mean (± standard error of mean, SEM) YM is increased in the superolateral, superomedial, inferolateral, and inferomedial quadrants by 46 ± 15%, 32 ± 11%, 67 ± 20%, and 53 ± 11%, respectively. In equatorial sclera, YM is increased by 139 ± 43%, 68 ± 27%, 143 ± 92%, and 68 ± 14%, respectively. The YM of pooled equatorial quadrants increased significantly more than that of the pooled posterior quadrants. Conclusions: Scleral collagen cross-linking by ultraviolet activation of riboflavin differentially increases scleral YM more in the equatorial than posterior sclera, and most in the lateral, equatorial sclera. Cross-linking might be used to arrest progressive myopia or to prevent staphyloma formation.
Bilateral ureteral obstruction is rapidly accompanied by ER stress and activation of autophagic degradation of IMCD proteins, including AQP2

After the release of bilateral ureteral obstruction (BUO), postobstructive diuresis from an impaired urine concentration mechanism is associated with reduced aquaporin 2 (AQP2) abundance in the inner medullary collecting duct (IMCD). However, the underlying molecular mechanism of this AQP2 reduction is incompletely understood. To elucidate the mechanisms responsible for this phenomenon, we studied molecular changes in IMCDs isolated from rats with 4-h BUO or sham operation at the early onset of AQP2 downregulation using mass spectrometry-based proteomic analysis. Two-hundred fifteen proteins had significant changes in abundances, with 65% of them downregulated in the IMCD of 4-h BUO rats compared with sham rats. Bioinformatic analysis revealed that significantly changed proteins were associated with functional Gene Ontology terms, including “cell-cell adhesion,” “cell-cell adherens junction,” “mitochondrial inner membrane,” “endoplasmic reticulum chaperone complex,” and the KEGG pathway of glycolysis/gluconeogenesis. Targeted liquid chromatography-tandem mass spectrometry or immunoblot analysis confirmed the changes in 19 proteins representative of each predominant cluster, including AQP2. Electron microscopy demonstrated disrupted tight junctions, disorganized adherens junctions, swollen mitochondria, enlargement of the endoplasmic reticulum lumen, and numerous autophagosomes/lysosomes in the IMCD of rats with 4-h BUO. AQP2 and seven proteins chosen as representative of the significantly altered clusters had a significant increase in immunofluorescence-based colocalization with autophagosomes/lysosomes. Immunogold electron microscopy confirmed colocalization of AQP2 with the autophagosome marker microtubule-associated protein 1A/1B-light chain 3 and the lysosomal marker cathepsin D in IMCD cells of rats with 4-h BUO. We conclude that enhanced autophagic degradation of AQP2 and other critical proteins, as well as endoplasmic reticulum stress in the IMCD, are initiated shortly after BUO.
Study of Cytotoxic Effect of Methanolic Extract of Ferula Assa - Foetida Resin of Mashhad and Yazd on MDA - MB - 231 Cell Line

New cell - cu lture biotechnology enables us to culture cancer cells in vitro and to find, design, and manufacture new drugs. Active ingredients in herbal medicines enjoy biological balance because other materials accompany them and, hence, these medicines do not cause side effects for the human body and, accordingly, have substantial superiority and advantage over chemical drugs. Assa - foetida gum was extensively used in traditional Iranian medicine. Plants of the same species that grow in different habitats have differe nt percentages of active ingredients depending on the water, air, climatic conditions, and even angle of incidence in their habitats. Therefore, this study was conducted to evaluate and compare cytotoxic effects of methanol extracts prepared from assa - foet ida gum obtained from South Khorasan and Yazd Provinces on the breast cancer cell line MDA - MB - 231. Methods and Materials: Assa - foetida gum was collected from South Khorasan and Yazd and its methanol extract was prepared. The cancer cell line MDA - MB - 231 was cultured on RPMI - 1640 culture medium containing 10% fetal bovine serum and 5% CO2 and was incubated in the presence of various methanol extract concentrations for 24, 48, and 72 hours. The MTT method was employed to calculate the survival rate of cells. Discussion and Conclusions: Results indicated that, of the three exposure intervals of 24, 48, and 72 hours, methanol extracts of assa - foetida gum from South Khorasan and Yazd had their maximum cytotoxic effect on the cancer cell line MDA - MB - 231 at the 48 - hour exposure interval.
BUSINESS NETWORK AS ORGANIZATIONAL MEMORY AND HEURISTIC PROBLEM SOLVING. INSIGHTS FROM A LITERATURE REVIEW

The aims of this paper is to give a base of discussion about the relation between business network and organizational memory and heuristic literature. More precisely, the paper compares different approaches to heuristics and propose an evaluation of the role of heuristic processes in business network. Following an analysis of heuristic based on the ecological rationality approach, a view where business network are a base for activating heuristic processes and problem solving is proposed. On the methodological level, the work presented here is conceptual, based on a wide-ranging literature review. In business networks heuristic rules emerge and are taught and learnt. Business network can give a base for retrieval of information as part of the organizational memory. At the same time, search rule and decision rules are part the base to define heuristic problem solving. In business network memory can be stored in actors, resources and activity. Actors’ cognitive activities are central issues in the capability to acquire information, but organizational memory in business network refers to stored information from interaction and actors’ history that is brought to bear on present behavior. This 1 The author wishes to thank two anonymous referees for useful comments and suggestions on previous versions of this paper and Professor Gerd Gigerenzer for suggestions and for giving him the opportunity for a study term at the Max Planck Institute for Human Development, Adaptive Behavior and Cognition Group, in Berlin. information is stored as a consequence of implementing activities to which they refer, by actors’ recollections and through shared interpretations.
SENSOR LESS VOLTAGE CONTROL OF CHB MULTILEVEL INVERTER FED THREE PHASE INDUCTION MOTOR WITH ONE DC SOURCE PER EACH PHASE

In this paper a single DC source per phase cascaded h bridge (CHB) three phase five level inverter fed induction motor with minimum number of switches and a single capacitor is proposed. Maximum all available switching 1 International Journal of Pure and Applied Mathematics Volume 120 No. 6 2018, 4079-4097 ISSN: 1314-3395 (on-line version) url: http://www.acadpubl. eu/hub/ Special Issue http://www.acadpubl. eu/hub/
Extended Use of Mobile Banking System: The Effects of Switching Cognitive Gears

The proliferation of mobile devices ushers a new era of financial services. Although various users already adopted mobile banking systems, their insufficient utilization of systems become a pressing issue. Encouraging individuals to engage in extended use, that is, applying more available system features to support their financial tasks, is an efficient approach for financial institutions to extract value from customers’ alreadyin-use mobile banking systems. However, a relevant theoretical account for such discretionary post-adoptive usage is still in its infancy. Based on the switching cognitive gears perspective, this study proposes four types of triggers (i.e., new tasks, changes in system environments, other people’s uses, and deliberate initiatives) that will prompt the active cognitive processing of individuals that leads to their extended use of mobile banking systems. We further propose the methodology to operationalize extended use and empirically validate the research model, and then discuss the possible theoretical contributions and practical implications.
Stakeholders perceptions regarding partial disclosure of Corporate Social Responsibility Disclosure in India: An Empirical Study

Aim The aim of this research paper is to explore the views and perceptions of different stakeholder regarding reason behind the partial disclosure of Corporate Social Responsibility Disclosure (CSRD) performed by Indian Corporate. Research Methodology The present study was an empirical study based on primary data. The data collection tool used for the study was structured questionnaire. The sample consisted of 400 respondents which were categorized into 4 groups –Academicians, Investors, Government and financial managers. To test the reliability of the questionnaire responses one hypothesis was made and which was rested by using Kruskal wallis test.
INTEGRATION OF SHIP HULL FORM MODELING BASED ON SUBDVISION SURFACES WITH OTHER SHIP DESIGN TOOLS

The industry standard for the representation of hull forms are tensor-product B-spline surfaces. However, tensor-product B-splines are limited to four-sided surfaces. Aside of the necessity to compose hull surfaces of several patches, it makes hull form modeling and fairing inefficient. An alternative are generalized B-spline surfaces. They originate from the field of subdivision surfaces, whereas the term subdivision refers to a method that enables B-spline surfaces of arbitrary complexity. Hull form representation based on generalized B-splines improves hull form modeling. To be employed for ship design in practice, it is essential to provide an integration with other design tools. Naturally, this is a matter of data exchange. This article describes a method to convert a generalized B-spline surface to a collection of conventional Bézier patches. These patches may be shared with other design tools using a general purpose file format such as IGES.
A Micro-impinger Sampling Device for Determination of Atmospheric Nitrogen Dioxide

ABSTRACT There is an increasing demand for the determination of gaseous pollutants present in both outdoor and indoor environments. It is the result of a growing awareness that good air quality is fundamental to the health of the population. Gas monitors capable of reliable measurements are a global necessity. In this work, we developed a low cost and portable microsampler for gaseous pollutants, using a µ-impinger bubbler containing 500 µL of absorbing reagent. The microsampler was evaluated in the detection of NO2 using the Griess-Saltzman reagent (GS). The µ-impinger enabled the determination of NO2 concentrations lower than 15 µg m–3 (~8 ppb) using a 50 mL min–1 sample flow rate during 30 min. This NO2 concentration is 10 times lower than the EPA air quality standard. In the calibration procedure, standard atmospheres with NO2 concentrations from 15 to 165 µg m–3 were used. The limit of detection was 14 µg m–3 considering 3.3 times the standard deviation of the blank signal. The relative error was 12.0%, and the coefficient of variation was 6.9%. The portable sampling procedure can be used in remote areas where there is no public electricity supply. The detection limit could be improved further by using longer sampling times and/or higher sampling flow rates. The method is selective and highly sensitive.
A Teaching Device for Furlow Palatoplasty

The Furlow double-opposing z-plasty technique of palate repair has become a common treatment for cleft palate. The procedure is more complicated than other methods of palate closure and is difficult for the trainee to visualize; It Is even more difficult for the layperson without prior understanding of the concept of z-plasty to understand. A simple, inexpensive, portable model is described that shows the key elements of the repair and can be used for parent, patient, student, and resident teaching.
Enterovesical Fistulas Secondary to Crohn's Disease: Medical versus Surgical Therapies

The purpose of this study is to evaluate the efficacy of medical therapies, especially infliximab, to induce remission of enteric fistulas in Crohn’s disease (CD). Similarly to CD, chronic transmural inflammation of the bowel, diverticulitis and other pathologies may predispose to the development of fistulas. The risk of fistulization secondary to CD ranges from 17% to 80%. We focused on enterovesical fistulas, which statistically represent 10% of all fistulas secondary to CD. MATERIAL AND METHODS. In this study we decided to implement a therapeutic program with infliximab 5 mg/kg associated with steroids, which proved to be the most effective method of treatment. From January 2003 to March 2005, we studied 4 patients with CD and enterovesical fistulas. All patients underwent NMR, colonoscopy and cystoscopy combined with fistulography; a therapeutic strategy with cortisone, mesalazine, nutritional therapy and infliximab was es-
Effects of Presurgical Orthopedic Treatment in Infants with Complete Bilateral Cleft Lip and Palate

Objective: To align the protruding premaxilla in infants with bilateral cleft lip and palate (BCLP), an intraoral appliance (i.e., Hotz plate) and an extraoral appliance consisting of a band covering the head and elastics are used as a presurgical orthopedic treatment in our clinic. The aim of this study was to analyze the configuration and position of the premaxilla and the vomer in infants with BCLP and to investigate the factors generating deviation and bending of the vomer and twisting of the premaxilla. Patients: Palatal casts were obtained serially from 10 infants with complete BCLP from 1 to 3 months of age. Measurements: These casts were automatically measured using a highly accurate contact-type measuring apparatus. After three-dimensional wire frame models generated from the serial casts were automatically superimposed, the magnitude and direction of the shift were calculated. A discriminant analysis was used for investigation of predictor variables generating the twisting or bending vomer. Results and Conclusions: The vomer was found to be bent in two infants and the premaxilla was twisted in three infants. In the infants whose vomers were bent, the magnitude of the posterior shift of the premaxilla was greater than that of the inferior shift. A discriminant analysis indicated that at 1 month of age, a greater inclination and a smaller deviation of the vomer and a longer distance between the cleft edges of the lateral segments had a tendency to be associated with bending of the vomer or twisting of the premaxilla.
Comparison of the Effect of Aerobic and Resistance Training on Cardiovascular Risk Factors in Parkinson's Women

People with low-mobility are at increased risk for cardiovascular disease. Patients with Parkinson's Disease (PD) are less interested in participating in exercise activities due to the nature of the disease. Regular exercise and physical activity can play protective roles against heart disease by reducing risk factors. This study aimed to compare the effects of aerobic and resistance training on cardiovascular risk factors in women with PD. This quasi-experimental study was carried out on 45 women with PD who were randomly assigned to one of three groups: aerobic, resistance groups, and control group. Before and after training sessions, variables of weight, Body Mass Index (BMI), heart rate at rest state, maximum oxygen consumption, blood pressure, and lipid profiles of participants were measured. Data were analyzed using SPSS software version 21 and Paired Sample t-test, ANOVA and Bonferroni post-hoc test. A significant level of P≤0.05 was considered. Demographics of physiological characteristics of subjects was congruent in all three groups in the baseline. After aerobic and resistance training, levels of triglyceride, LDL, total cholesterol, fat percentage, resting heart rate, weight, BMI and systolic blood pressure were significantly decreased (p<0.05). This change was more pronounced in the aerobic group; in contrast, variables of maximum oxygen consumption and HDL were meaningfully increased in participants of both experimental groups (p<0.05). The results showed that both types of aerobic and resistance training can reduce the risk factors of cardiovascular disease in women with PD, while the effect of aerobic training on reducing risk factors was more than resistance training.
Dynamic Systematic Risk Preference of Institutional Investors∗

We re-examine the systematic risk (beta) preference of institutional investors and expand the literature by investigating its implications on the future market volatility, the choice of good and bad betas, and distressed mutual funds. In our simple model where a fund manager’s payoff function depends on excess returns relative to a benchmark, the manager would choose to hold stocks with higher betas than the benchmark; and the optimal level of his portfolio beta depends on his perceived factor returns and volatility, reflecting his trade-off between expected performance and tracking error. Using a unique triple dependent sorting approach to match stocks with their characteristic-based benchmarks, we find empirical evidence confirming the model predictions. We document that mutual funds and other institutional investors choose stocks with betas that are statistically and economically higher than their corresponding benchmark betas, and that this result is not due to other alternative explanations, including the effects of institutional investors’ liquidity preference and their trading activities on the betas of stocks. Furthermore, we demonstrate that the average beta choice of fund managers can predict the future market volatility after careful controls, which is consistent with the model prediction. On the other hand, although we find that fund managers are tilted toward high good-beta as well as high bad-beta stocks, they appear tilted more toward high good-beta stocks than high bad-beta stocks, suggesting that fund managers prefer good beta to bad beta. Moreover, we show that the finding of managers holding higher beta stocks is more pronounced for distressed mutual funds in response to large money outflows, which is consistent with the risk shifting story.
Familial inheritance of endometriosis in a British population. A case control study

SummaryThe incidence of endometriosis in the tirst degree relatives of 64 women with a visual diagnosis of endometriosis, the index group, was compared with 128 case controls with no known endometriosis. Data was collected by interview and attempts made to independently verify the diagnosis of the relatives. The number with a first degree relative with endometriosis was six (94 per cent) in the index group which was higher (P < 0-05, Fisher's exact test) than the two women (1-6 per cent) in the control group. The 95 per cent coincidence limits for the difference in percentages were 0-36 to 15-3 per cent. Within the total population of tirst degree relatives the percentage with endometriosis was also higher (P < 0-05) in the index group (5-5 per cent) compared with the control group (0-7 per cent); coincidence limits for difference 0-6 to 8-5 per cent. This verifies previous reports of a higher incidence of endometriosis in the first degree relatives of suffers of endometriosis, suggesting there may be a f.
Monetary Policy for Commodity Booms and Busts

Macroeconomic volatility in commodity-exporting economies is closely tied to fluctuations in international commodity prices. Commodity booms improve exporters' terms of trade and loosen their borrowing conditions, while busts lead to the reverse. This paper studies optimal monetary policy for commodity exporters in a small open economy framework that includes a key role for financial conditions. We incorporate the interaction between the commodity and financial cycles via a working capital constraint for commodity producers, which loosens as commodity prices increase. A rise in global commodity prices causes an inefficient reallocation towards the commodity sector, which expands and increases its demand for inputs. The real exchange-rate appreciates, but because domestic fims do not internalize that the appreciation reduces the scale of the reallocation, they do not raise prices enough. An inefficient boom takes place, with inflation rising and output increasing relative to its welfare-maximizing level. Returning inflation to target is not sufficient to close the output gap, leaving the policymaker facing a stabilization tradeoff. The optimal policy lets the exchange rate appreciate and raises interest rates, with a larger rate rise required the greater the loosening in borrowing conditions. The paper compares alternative policy rules and discusses a key practical challenge for emerging and developing economies: how to transition to a stable path from initial conditions of high and persistent inflation.