Miracle-dz/UniFAR-FTUs huggingface dataset:
Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry

Background The extent to which angina is associated with future cardiovascular events in patients with coronary artery disease has long been debated. Methods and Results Included were outpatients with established coronary artery disease who were enrolled in the REACH registry and were followed for 4 years. Angina at baseline was defined as necessitating episodic or permanent antianginal treatment. The primary end point was the composite of cardiovascular death, myocardial infarction, or stroke. Secondary end points included heart failure, cardiovascular hospitalizations, and coronary revascularization. The independent association between angina and first/total events was examined using Cox and logistic regression models. Out of 26 159 patients with established coronary artery disease, 13 619 (52%) had angina at baseline. Compared with patients without angina, patients with angina were more likely to be older, female, and had more heart failure and polyvascular disease (P<0.001 for each). Compared with patients without angina, patients with angina had higher rates of first primary end‐point event (14.2% versus 16.3%, unadjusted hazard ratio 1.19, CI 1.11–1.27, P<0.001; adjusted hazard ratio 1.06, CI 0.99–1.14, P=0.11), and total primary end‐point events (adjusted risk ratio 1.08, CI 1.01–1.16, P=0.03). Patients with angina were at increased risk for heart failure (adjusted odds ratio 1.17, CI 1.06–1.28, P=0.002), cardiovascular hospitalizations (adjusted odds ratio 1.29, CI 1.21–1.38, P<0.001), and coronary revascularization (adjusted odds ratio 1.23, CI 1.13–1.34, P<0.001). Conclusions Patients with stable coronary artery disease and angina have higher rates of future cardiovascular events compared with patients without angina. After adjustment, angina was only weakly associated with cardiovascular death, myocardial infarction, or stroke, but significantly associated with heart failure, cardiovascular hospitalization, and coronary revascularization.
Pneumonia caused by rhinovirus.

Rhinovirus infections, although usually limited to the upper respiratory tract, can extend beyond the oropharynx and may cause complications in the lower respiratory tract, including pneumonia [1‐3]. We describe a case of rhinovirus pneumonia in an infant boy in which rhinovirus was recovered from the lung and analysis of hyperimmune serum to the causal rhinovirus revealed localization of rhinovirus antigen in the lung. At 16 and 22 days of age, an infant boy underwent operations for cardiovascular anomalies, including an interrupted aortic arch and a ventricular septal defect. After the operations, he developed transfusion-associated graft-versus-host disease and died of multiple organ failure at the age of 59 days. At autopsy, the histopathologic findings for the hematopoietic system and the skin were consistent with transfusionassociated graft-versus-host disease. Examination of the lungs showed mild hyperplasia of the bronchial epithelium with cytological alterations, thickening of the alveolar septum, marked hyperplasia of the alveolar lining cells, and desquamating swollen alveolar epithelial cells and macrophages in the alveoli; how
A decision support framework for cooperation in make-to-order production

Abstract This paper proposes a method which assists the ﬁrms for cooperating inmake-to-order production. We especially focus on the operational decision levels ofmanufacturing companies : the forecast scheduling and the real-time scheduling. Themethod organizes a production process which is distributed over several companies,by lowering the production stocks with the aim of decreasing production costs. In theselected approach, the global organization is achieved progressively by a set of coop-erations between pairs of actors of the supply chain. We study in particular the cus-tomer/supplier relationship for which the cooperation process concerns the attributesof the orders transmitted by the customer to the supplier. We assume that the relationis governed by a cooperation contract which deﬁnes a more contractual framework tothe cooperation between the decision-makers. Our objective is to design support toolsthat assist them during this cooperation process. 1 IntroductionMore and more often, the diversiﬁcationof their productionor the specialization of theirtradeinduce the companies to collaborate with numerous partners, in the context of networks so-called supply chains. New communication and information technologies increase the qualityand the frequency of the data exchanges and allow to ensure the coherence of informationwhich are shared between different actors. Nevertheless, they do not solve the coherenceproblembetween thelocaldecisions ofeach partnersand theglobalorganizationofthesupplychain. Thus, each actor is free to change at any moment a decision, possibly inducing a globalorganisational instability.To counteract this problem, the decisional autonomy of each actor needs to be speciﬁedin order to improve the global stability of the decisions. For this purpose, we suppose thatthe actors adopt a cooperation process in which a local decision, that affects the organizationof external companies, should be ﬁrst negotiated, in the aim of increasing the lifetime ofthe decision. In the same way, any change of a local decision that may have impacts on theexternal partners, induces its author to renegotiate with his partners in order to achieve atrade-off which satisﬁes the community. In the following, the set of partners involved in thecooperation is called a business coalition.In the area of production systems, cooperation processes may have a lot of advantages.First, they allow a better tension of production ﬂows, a better adaptation of the workingcapacities, and a better stability of the organization of the business coalition. So, they inducea global reduction of the production costs. On the other hand, the cooperation processes allow
Chloroplastic ATP synthase builds up a proton motive force preventing production of reactive oxygen species in photosystem I

Over-reduction of the photosynthetic electron transport (PET) chain should be avoided, because the accumulation of reducing electron carriers produces reactive oxygen species (ROS) within photosystem I (PSI) in thylakoid membranes and causes oxidative damage to chloroplasts. To prevent production of ROS in thylakoid membranes the H+ gradient (ΔpH) needs to be built up across the thylakoid membranes to suppress the over-reduction state of the PET chain. In this study, we aimed to identify the critical component that stimulates ΔpH formation under illumination in higher plants. To do this, we screened ethyl methane sulfonate (EMS)-treated Arabidopsis thaliana, in which the formation of ΔpH is impaired and the PET chain caused over-reduction under illumination. Subsequently, we isolated an allelic mutant that carries a missense mutation in the γ-subunit of chloroplastic CF0 CF1 -ATP synthase, named hope2. We found that hope2 suppressed the formation of ΔpH during photosynthesis because of the high H+ efflux activity from the lumenal to stromal side of the thylakoid membranes via CF0 CF1 -ATP synthase. Furthermore, PSI was in a more reduced state in hope2 than in wild-type (WT) plants, and hope2 was more vulnerable to PSI photoinhibition than WT under illumination. These results suggested that chloroplastic CF0 CF1 -ATP synthase adjusts the redox state of the PET chain, especially for PSI, by modulating H+ efflux activity across the thylakoid membranes. Our findings suggest the importance of the buildup of ΔpH depending on CF0 CF1 -ATP synthase to adjust the redox state of the reaction center chlorophyll P700 in PSI and to suppress the production of ROS in PSI during photosynthesis.
AMBLYOPIA SCREENING IN KINDERGARTENS WITH TNO STEREOTEST

One hundred and fifty children between 3 and 6 years old were screened for amblyopia with TNO stereotest in their kindergartens. Thirty screening positive children were found of whom 3 were amblyopic with strabismus and no stereopsis. Re‐testing showed that 19 children were false screening positive. Three children with refractive errors and equally impaired vision in both eyes were not detected. The test was found suitable for screening of monocular amblyopia in kindergartens, as it was easy to administrate and indicated all children with monocular amblyopia.
Genome Sequence of Pseudomonas putida Strain ASAD, an Acetylsalicylic Acid-Degrading Bacterium

ABSTRACT Pseudomonas putida strain ASAD was isolated from compost because of its ability to utilize aspirin (acetylsalicylic acid) as a carbon and energy source. We report the draft genome sequence of strain ASAD, with an estimated length of 6.9 Mb. Study of this isolate will provide insight into the aspirin biodegradation pathway.
Patient experience a vital consideration in crafting solutions for healthcare challenges.

Healthcare providers around the world face the same challenges. Broadly speaking, they include five key issues: access to health care; prevention of chronic and complex conditions; reducing the burden of iatrogenic disease; supporting people with established chronic diseases; and tackling obesity. I have put the latter issue in a category of its own because it is probably the most significant challenge to health care in the developed world and is increasingly a marker of poor nutrition elsewhere in the world.1 In most cases health care, especially the government-subsidised kind, continues to be delivered via the services of a doctor. The patient first attends a generalist who will determine the best course of action, including if referral for more specialised and therefore more expensive treatment is necessary. In making this assessment of the patient’s need, context is everything. The following may apply in assessing outcomes in relation to the practitioner-patient dyads: The age and gender of those involved. The social, political, and economic conditions. The history of both in the lead-up to current events. The culture of both. The practitioner’s professional interests. The ideas, concerns, and expectations of both. At the same time, in most cases in general practice what the practitioner offers has only a peripheral impact on the outcome. Most minor self-limiting illnesses will resolve spontaneously. However, there is a significant risk that inappropriate treatment, or for that matter any prescribed treatment, could do more harm than good. The outcomes are similarly dependent on the ability to practice the art of medicine.
Merkle tree-based wormhole attack avoidance mechanism in low power and lossy network based networks

Smart metering application has received a lot of attention from the research community lately. Usually, low power and lossy network runs on routing protocol for low power and lossy networks protocol, which constructs a directed acyclic graph structure for its normal operation. In this paper, we devise a wormhole attack scenario in such a network. Furthermore, we propose a Merkle tree-based authentication mechanism, which runs on the notion of constructing a tree of hashed security information. We analyze the approach by formulating the wormhole attack scenario as a graph theoretic problem and show the effectiveness of the proposed Merkle tree-based approach for authenticating communications. Furthermore, we perform simulations in network simulator 2 to observe the network performance by adopting a Merkle tree-based approach to prevent from disrupting the links, and we observe better throughput, reduction in jitter, and end-to-end delay as compared with scenarios with wormhole attacks and no avoidance mechanism. In the end, we take a step toward optimizing the performance of the mechanism by proposing an effective tree traversal algorithm, which works on the notion of electing nodes as a root in a large scale network from where a Merkle tree will be originated. The mechanism with the traversal algorithm assists in managing the authentication in a huge network, which is broken down into many trees avoiding wormhole attacks in the network. Copyright © 2014 John Wiley & Sons, Ltd.
Robots as Conversational Mediators

We propose a system in which a humanoid robot acts as a broker of a human-robot-human conversation, with one of the robot-human communication performed remotely. The robot plays a role of a \textit{mediator}, summarizing relevant information, translating across languages or point-of-views and even censoring some information.
Monosynaptic excitation of hippocampal CA1 pyramidal cells by afferents from the entorhinal cortex

It is well established that fibers originating in the superficial layers (I1 and 111) of the entorhinal cortex assemble to form the perforant path projection, terminating monosynaptically onto the dendrites of dentate granule cells and the apical dendrities of CA3 and CAI pyramidal neurons (see Fig. 1 A Steward, 1976; Swanson and Cowan, 1977; Tamamaki and Nojyo, 1993; Witter, 1993). Early studies examining perforant path input to dentate granule cells characterized the nature and strength of this projection with respect to its postsynaptic excitatory effect and its capability for suprathreshold activation (Andersen et al., 1966a). Entorhinal input to the pyramidal cell regions has also been shown to be excitatory, but initial electrophysiological studies were in dispute over the strength of perforant path input to Ammon’s horn, Since as early as 1961, controversy has existed over the capability of perforant path input to excite hippocampal pyramidal cells monosynaptically. Andersen and Loyning (1 962) reported that they were not able to evoke population spikes in CAI with electrical stimulation of the angular bundle. They concluded that their findings were consistent with “. the concept proposed for motoneurons (Eccles, 1957; Fadiga and Brookhart, 1960) that there is a decreased effectiveness for orthodromic firing the farther the distance between the synapses and the cell body. ” In contrast, von Euler (1962) and Gloor and colleagues (1962), presented evidence for monosynaptic excitation of CAI neurons evoked by stimulation of entorhinal afferents. In addition, Spencer and Kandel (1962) presented results of intracellular recordings from CAI pyramidal cells clearly demonstrating short-latency action potentials (<5 ms) consistent with monosynaptic activation, which were easily distinguished from longer-latency action potentials (> 17 ms) presumably excited via the trisynaptic pathway. Despite evidence demonstrating monosynaptic excitation of CAI pyramidal neurons by entorhinal cortical afTerents, characterizations of hippocampal physiology have emphasized multi-synaptic entorhinal input to CA3 and CAI mediated by the intrinsic pathway rather than the direct, monosynaptic projection.
An HBC-based biosensor transmitter for time division multiple access network

A wireless medical biosensor using Human Body Communication(HBC)for data transmission is presented in this paper. HBC is included in the IEEE Standard 802.15. 6 for Local and Metropolitan Area Network and presents the characteristic of being a new non-radio frequency type of wireless communication as it uses the human body as a transmission medium. The multiple access technique should be Time Division Multiple Access(TDMA) and data are transmitted over HBC capacitive coupling aside from a bio-signal sensing system. The transmitter time characteristics shows the feasibility of implementing a TDMA body sensors star network centralized into a single hub for a single connection to Wide Area Networks. The proposed system is composed by a bio-sensor unit and an HBC transmitter.
Change Magnitude Does Not Guide Attention in an Object Change Detection Task

Investigations of change detection consistently reveal an effect of change magnitude: changes involving more object parts are detected more easily than those involving fewer parts. Whether large changes improve detection by providing stronger preattentive signals to the change location is subject to debate. We report a cued object change detection experiment that tested this hypothesis while controlling for stimulus familiarity, semantic knowledge, and change type (addition versus deletion). We found strong magnitude effects regardless of whether trials were validly or invalidly cued. The size of the cueing effects, which were exhibited for all the change magnitudes examined, did not decrease with the number of parts changing. These findings provide little support for a preattentive guidance hypothesis and instead support the thesis that change detection requires attention.
Roles of Exogenous Technologies in Vehicle Innovation : Cases from a Japan’s Automotive Parts Manufacturing Firm

This paper explores the roles of technological innovations in the growth of Japan’s motor vehicle industry, mainly from technology spillover perspective from the early 2000s to today. An empirical analysis focusing on business performances, R&D investments, and patent applications taking a noteworthy unique case in Japan was attempted. Empirical analyses on the productivity of patent to technology stock, use of exogenous technologies for their own technological innovation on its Automotive Business Unit elucidated that innovation capabilities, incorporation of exogenous technologies, and profit generation makes a virtuous cycle of continuous technological innovation. Furthermore, we found that the range of technology spillovers is not only expanding along with the development of information communication technology, but also superposing itself intricately between organizational (industry– firm–business unit) layers.
Evaluating CollaboRATE in a clinical setting: analysis of mode effects on scores, response rates and costs of data collection

Background Shared decision-making (SDM) has become a policy priority, yet its implementation is not routinely assessed. To address this gap we tested the delivery of CollaboRATE, a 3-item patient reported experience measure of SDM, via multiple survey modes. Objective To assess CollaboRATE response rates and respondent characteristics across different modes of administration, impact of mode and patient characteristics on SDM performance and cost of administration per response in a real-world primary care practice. Design Observational study design, with repeated assessment of SDM performance using CollaboRATE in a primary care clinic over 15 months of data collection. Different modes of administration were introduced sequentially including paper, patient portal, interactive voice response (IVR) call, text message and tablet computer. Participants Consecutive patients ≥18 years, or parents/guardians of patients <18 years, visiting participating primary care clinicians. Main measures CollaboRATE assesses three core SDM tasks: (1) explanation about health issues, (2) elicitation of patient preferences and (3) integration of patient preferences into decisions. Responses to each item range from 0 (no effort was made) to 9 (every effort was made). CollaboRATE scores are calculated as the proportion of participants who report a score of nine on each of the three CollaboRATE questions. Key results Scores were sensitive to mode effects: the paper mode had the highest average score (81%) and IVR had the lowest (61%). However, relative clinician performance rankings were stable across the different data collection modes used. Tablet computers administered by research staff had the highest response rate (41%), although this approach was costly. Clinic staff giving paper surveys to patients as they left the clinic had the lowest response rate (12%). Conclusions CollaboRATE can be introduced using multiple modes of survey delivery while producing consistent clinician rankings. This may allow routine assessment and benchmarking of clinician and clinic SDM performance.
The Significance of the Trifurcation of the Road: Clinical Confirmation and Illumination

n the Oedipus myth, the murder of Laius by his son occurs at a fork in the road; in 1923, Abraham wrote that this site was symbolic of the female genitals. According to his data, the bifurcation’ in the road indicated the location of the female genitals at the junction of the torso and the two lower extremities. Thus, the wish to destroy the father and to possess the mother sexually are both expressed in the myth by the conflict which occurs at the bifurcation, at the site of the female symbol. Abraham supported this hypothesis with clinical material. He reported a patient’s dream in which bifurcation carried this symbolism.
Factors Influencing Consumers Purchase Intention towards Organic and Cloned Animal Food Products

Over the last decade, consumers are worrying about the quality of the food they eat because of food crises such as mad cow disease, the foot and mouth epidemic and the Belgian dioxin scandal (Miles and Frewer, 2001). Recurring food safety incidents have raised consumers concerns about the food quality and safety (Liu, Pieniak and Verbeke, 2013). This phenomenon is reflected in a growing demand of organic produce, which is International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 01 (2018) Journal homepage: http://www.ijcmas. com
Structure of Yeast Kinetochore Ndc10 DNA-binding Domain Reveals Unexpected Evolutionary Relationship to Tyrosine Recombinases*

Background: Ndc10 is a DNA-binding protein in yeast that is responsible for centromere formation. Results: The structure of the protein unexpectedly shows that it contains a type IB topoisomerase/λ-integrase fold. Conclusion: The structure demonstrates how the IB/Int fold has been adapted to a new cellular role. Significance: The structure is the first example of the IB/Int fold being used in a non-catalytic protein. We have solved the x-ray structure of the N-terminal half of the yeast kinetochore protein Ndc10 at 1.9 Å resolution. This essential protein is a key constituent of the budding yeast centromere and is essential for the recruitment of the centromeric nucleosome and establishment of the kinetochore. The fold of the protein shows unexpected similarities to the tyrosine recombinase/λ-integrase family of proteins, most notably Cre, with some variation in the relative position of the subdomains. This finding offers new insights into kinetochore evolution and the adaptation of a well studied protein fold to a novel role. By comparison with tyrosine recombinases and mutagenesis studies, we have been able to define some of the key DNA-binding motifs.