Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of Dasatinib in Human Plasma by Using Liquid Chromatography-Tandem Mass Spectrometry

A liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated to determine dasatinib (DAS) in human plasma. Protein precipitation procedure was used in sample preparation. The analyte and internal standard (dasatinib-d8 (DASD8) were separated on Waters Atlantis dC18 Column (75 × 4.6 mm, 3.5 μm). Multi reaction monitoring detection was performed by electrospray ionization in the positive ion mode. The MRM transitions of m/z 488.1 > 401.1 for DAS and 496.15 > 406.1 for DASD8 were used to quantify. The standard curve was found to be linear in the range of 1-400 ng/mL for dasatinib. The lower limit of quantification (LLOQ), using 200 μL human plasma, was 1 ng/mL. The developed and validated method could be applied to the bioequivalence study in human plasma samples.
The mussel-inspired assisted apatite mineralized on PolyJet material for artificial bone scaffold

Abstract With the development of three-dimensional (3D) printing, many commercial 3D printing materials have been applied in the fields of biomedicine and medical. MED610 is a clear, biocompatible PolyJet material that is medically certified for bodily contact. In this study, the polydopamine (PDA)/hydroxyapatite (HA) coating was added to the printed MED610 objects to evaluate its physical properties, cell proliferation, cell morphology, and alkaline phosphatase expression level. The results show that the PDA/HA coating helps printed objects to enhance the hardness, biocompatibility, and osteogenic differentiation potential. We expect that PDA/HA coatings contribute to the applicability of MED610 in biomedical and medical applications.
Comparative Study on Physicochemical Parameters Study of Oil Polluted Sites and Hydrocarbon Degradation Potentials of Heterotrophic Bacteria in Southern Nigeria

In this study, hydrocarbon degradation potentials of heterotrophic bacteria isolated from oil-polluted soil were examined; Samples were collected from Sakpenwa, an oil producing community in Tai LGA of Rivers State. The amounts of hydrocarbon in the soil samples were determined using Gas Chromatography-Flame Ionization Detector, GC- FID. The gravimetric analysis showed that the bacteria were capable of utilizing 96.9-99.7% the oil sample. Analysis of variance (ANOVA) carried out at 95% level of confidence showed that the degree of hydrocarbon degradation varied amongst isolates. Pseudomonas aeruginosa and Alcaligenes sp. showed highest degrading activities while Bacillus subtilis showed least activity. This study revealed that indigenous bacterial species possess the requisite gene necessary for hydrocarbon biodegradation. Biodegradation is most often the primary mechanism for contaminant destruction in the environment including petroleum contaminants.
A review of recent research and development of the effect of hydraulic fracturing on gas adsorption and desorption in coal seams

Permeability improvement of coal seams by hydraulic fracturing can promote desorption of coalbed methane. However, the water-block effect will restrain desorption of coalbed methane. Based on the essence of the physical adsorption of methane, competitive adsorption, substitution desorption, the capillary effect, and the Jamin effect are analyzed to study the effect of the critical moisture content and liquid water on methane adsorption and desorption. Simultaneously, the effects of the fluid pressure, fracturing fluid, fracturing time, pore pressure, and other variables on methane adsorption and desorption characteristics are analyzed. Then, problems that require further study are described.
The effect of equations of state on the performances of compositional grading models

ABSTRACT The effect of equations of state on the performance of compositional grading models to accurately predict compositional variation with depth in petroleum reservoir has been presented. Compositional grading models considered are isothermal model, zero thermal diffusion model, Haase’s thermal diffusion model, and Kempers thermal diffusion model. The performances of these models were simulated based on tuned equations of state. The simulation results were validated with experimental data and the associated error computed as percentage average absolute deviation. The results suggest that selection of suitable equations of state has a significant influence on the performances of the applied compositional grading models.
Effect of Different Sources of Phosphorus and Boron on Chemical Composition and Water Relations in Leaves, Growth, Productivity and Quality of Egyptian Cotton.

Two field experiments were carried out on clay soil in El-Gemmeiza Agric. Res. St., ARC, El-Gharbiya Governorate, Egypt during 2015 and 2016 seasons to study the effect of four phosphorus and boron fertilizers sources on leaves chemical composition, photosynthetic pigments and water relations, growth, seed cotton yield/fed and its components and fiber quality of Egyptian cotton cultivar Giza 86. A split-plot design with four replicates was used, where the main plots included treatments of phosphorus namely; A- Soil application of 22.5 kg P2O5/fed. as superphosphate (Control), B- Phosphate rock + Phosphorein (400g/30kg seed), C- Foliar application of 2 ml phosphoric acid/liter water, and D- Phosphorein (400g/30kg seed). , and the sub plots involved the sources of boron namely; 1- Control (without application), 2- Foliar spray with boric acid, 3- Foliar spray with B-Nano, and 4- Foliar spray with B-EDTA. The obtained important could be summarized as follows: 1-The phosphorus sources gave significant effect on leaves N, P, K, photosynthetic pigments, total sugars, total carbohydrates and proline contents, leaves water content, water deficit, relative water content and osmotic pressure in 2016 season, No. of open bolls/plant, boll weight, seed cotton yield/plant, seed cotton yield/fed, lint percentage and seed index in both seasons, in favor of soil application with 22.5 kg P2O5/fed, final plant height and No. of sympodia/plant, in favor of foliar application with phosphoric acid.2- Foliar application with boron treatments fertilization significantly affected leaves N, P, K, photosynthetic pigments, total sugars, total carbohydrates and proline contents, leaves water content, water deficit, relative water content, osmotic pressure and transpiration rate in 2016 season, plant height at harvest, No. of sympodia/plant, No. of open bolls/plant, boll weight, seed cotton yield/plant, seed cotton yield/fed. , lint percentage and seed index in both seasons, where the superiority was found in favor of foliar spray with B-Nano 5 g/liter water. 3-The interaction between phosphorus and boron fertilizers sources gave a significant effect on leaves N, P, K, photosynthetic pigments, total sugars, total carbohydrates and proline contents, leaves water content, water deficit, relative water content and osmotic pressure in 2016 season, boll weight, lint % and seed index in 2015 season and No. of open bolls/plant, seed cotton yield/plant, seed cotton yield/fed. , in 2015 and 2016 seasons, in favor of soil application with 22.5 kg P2O5/fed and foliar spraying with B-Nano 5 g/liter water.4- Upper half mean length, uniformity index, micronaire reading and fiber strength did not affect by the different phosphorus and boron sources and their interaction in both seasons.
Substrate‐Dependent Molecular and Nanostructural Orientation of Nafion Thin Films

The effects of film thickness and substrate composition on the ionomer structure in porous electrodes are critical in understanding pathways toward developing higher performance electrochemical devices, including fuel cells and batteries. Insights are gained into the molecular and nanostructural orientation dependence for thin Nafion films (12–300 nm thick) on gold, platinum, and SiO2 model substrates. Molecular orientation is determined from the birefringence measured using spectroscopic ellipsometry, while the nanostructural orientation of the ionic domains is measured using grazing‐incidence small‐angle X‐ray scattering. Density functional theory calculations for the molecular polarizability of the Nafion backbone and side chain show complimentary contributions to the measured birefringence values for the material. Nafion films prepared on SiO2 substrates exhibit a nearly isotropic molecular and nanostructural orientation. Films on gold and platinum display parallel backbone orientations, relative to the substrate, with decreasing film thickness. However, a birefringence transition toward molecular isotropy is observed for 30 nm thick films on Au and Pt; while the ionic nanostructured domains continuously align parallel to the substrate. This apparent isotropic molecular orientation with increasing domain orientation highlights the difference between the backbone and side chain orientation, a key finding for elucidating transport in confined films at the interfaces.
The Effect of Acid Hydrolysis Treatment on the Production of Nanocellulose Based on Oil Palm Empty Fruit Bunches

Nanocellulose has been known as promising reinforcing material in various polymer based product resulted to remarkable improvement in mechanical and thermal properties. Hence, studies to date have developed and explored various sources of biomass to produce nanocellulose. The aims of this study are to synthesize and fully characterize nanocellulose obtained from abundantly available oil palm empty fruit bunches via two different methods which are strong (H2SO4) and mild acid (H3PO4) hydrolysis at 50 °C for 3.5 hours. Based on the morphological study using Transmission Electron Microscopy, rod like nanocellulose was obtained using strong acid hydrolysis while mild acid hydrolysis produced long filament shape. X-Ray diffraction analysis showed that the degree crystallinity of nanocellulose produced from strong acid hydrolysis was higher which is 96% than that of mild acid hydrolysis recorded with 86%. While the sulphuric acid hydrolysis usually produces lower thermal stability than that of other types acid hydrolysis, surprisingly, in this study, the thermal stability of nanocellulose from strong acid hydrolysis was relatively similar to mild acid hydrolysis due to the formation of single crystal structure affording unique characteristic of the obtained nanocellulose.
Phytochemical, GC-MS and FT-IR Analysis of Papaver somniferum L

The present study was aimed to analysis of bioactive constituents of Papaver somniferum (Poppy seed). The ethanol extract of the seeds were subjected to Phytochemical Screening, Gas chromatographymass spectroscopic (GC-MS) and Fourier transform infrared spectroscopy (FTIR) analysis. GC-MS analysis of the seeds was performed using a Scion 436GC Bruker model nd Interpretation on mass spectrum GC-MS was conducted using the database of National Institute Standard and Technology (NIST) and IR spectrum was recorded in spectrophotometer (Shimadzu, IR Affinity1, Japan). Phytochemical screening for seeds extracts indicated the presence of various secondary metabolites like Alkaloid, Cardiac Glycosides, Flavonoid, Phytosterols and Terpenoids. GC-MS analysis of compounds with totally, Thirty Nine volatile compounds major chemical compounds were identified, such as 9-Octadecynoic acid(30.72%), 9-Tetradecen1-ol, acetate, (E)(24.02%), 9,12-Octadecadienoic acid, methylester, (E,E)(7.82%), cis-9,10-Epoxyoctadecan-1-ol (7.43%) and Undec10-ynoic acid(4.36%). FT-IR analysis of peak values with various functional compounds such as alcohols, phenols, carboxylic acids, aldehydes, amides, amino acids, anhydrides, esters, ketones, Unsaturated aliphatics, aromatics, unsaturated heterocycles, amines, Nitro compound, Alkanes, alkenes, sugars,Sulphur, phosphorus, and fluorine compounds. The present results concluded that the phytochemicals was observed in ethanol extract which revealed that the Papaver somniferum (Poppy seed) is potential use in different fields namely medical and pharmaceuticals and greatly valuable in medicinal practice for the treatment of several human aliments.
Synergistic antimicrobial activities of tea tree oil loaded on mesoporous silica encapsulated by polyethyleneimine

Abstract In an effort to improve the continuous bacteriostatic properties of tea tree oil (TTO), mesoporous silica (M41S) was prepared by sol-gel method using cetyltrimethylammonium bromide (CTAB) as template and tetraethyl orthosilicate (TEOS) as silica precursor, which was employed as a carrier for TTO. M41S loaded with TTO was then coated with polyethylenimine (PEI) via electrostatic interactions to prepare essential oil/M41S@polyethyleneimine composites (TTO/M41S@PEI). The corresponding structures and morphologies of the as-synthesized materials were systematically studied by N2 adsorption/desorption measurements, X-ray powder diffraction (XRD) and thermogravimetry (TGA). The results confirmed that TTO could be loaded into channels and PEI was found to coated on the outer surface of M41S. Importantly, the modification of PEI did not change the mesostructure of the two-dimensional hexagonal phases of M41S. In addition, the anti-bacterial abilities of TTO/M41S@PEI could be studied by using inhibition zones method. Such study showed that PEI and TTO exhibited synergistic anti-bacterial effects. The bacteriostasis slope of TTO was 2.265, and the slope of TTO/M41S@PEI was 3.275. These findings indicated that the inhibition rate of TTO/M41S@PEI was higher than that of TTO using the same number of colonies. Additionally, the sustained release behavior of TTO/M41S@PEI could be described by the logistic kinetic model. Even after 240 h of natural release, TTO/M41S@PEI still exhibited a stable and sustained bacteriostatic effect compared with TTO. Graphical Abstract
The relationship between the unsaturated permeability coefficients (UPC) determined and oxidation-reduction potential (ORP) in the subsurface wastewater infiltration system (SWIS)

The estimation of unsaturated permeability coefficients (UPC) is of great importance on the properties of the matrix. Aim to study the relationship between the UPC and oxidation – reduction potential (ORP) in different matrix depths in the subsurface wastewater infiltration system (SWIS) and provide scientific basis for regulating SWIS and increasing pollutant removal, a test experiment of simulating the SWIS which included an inflow period (12 h) and a drying period (12 h) in one cycle was designed with a hydraulic load of 0.10 m3·(m2·d)–1. Results investigated that ORP could increase with UPC increasing in 70 and 115 cm and decrease with the UPC increasing in 100 and 130 cm matrix depths. Phenomena indicated that capillary action could affect UPC and ORP obviously. Moreover, the existence of oxygen and low volumetric water contents could impose UPC and ORP. UPC in the 100 cm matrix depth below proved that anaerobic area could be found in aerobic environment under alternation conditions. UPC in different matrix depths of a satisfactory SWIS could change from 2.49 × 10–7 to 1.16 × 10–3 cm·s–1. Treated water met reused requirements and no clogging was found.
Teaching Robot and Its Trajectory Planning Generation

—This paper focuses on designing a kind of six degree of freedom teaching robot (STROB) and developing its trajectory planning method. STROB structure is introduced and kinematics parameters model is established. In order to make STROB generate smooth and continuous trajectory, non-uniform B-splines interpolation methods is analyzed and used to generate the robot's curved trajectory path. The simulation and practical application verify the proposed method effectiveness. The designed STROB can not only generate smooth and continuous trajectory path fast and smoothly, but also has the features that the robot body structure and control system are open and the inner structure of each joint is visible and debugged separately. It is suitable for popularization and application in teaching.
Privacy in Control and Dynamical Systems

Many modern dynamical systems, such as smart grids and traffic networks, rely on user data for efficient operation. These data often contain sensitive information that the participating users do not wish to reveal to the public. One major challenge is to protect the privacy of participating users when utilizing user data. Over the past decade, differential privacy has emerged as a mathematically rigorous approach that provides strong privacy guarantees. In particular, differential privacy has several useful properties, including resistance to both postprocessing and the use of side information by adversaries. Although differential privacy was first proposed for static-database applications, this review focuses on its use in the context of control systems, in which the data under processing often take the form of data streams. Through two major applications—filtering and optimization algorithms—we illustrate the use of mathematical tools from control and optimization to convert a nonprivate algorithm to its private counterpart. These tools also enable us to quantify the trade-offs between privacy and system performance.
Mechanical dewatering characteristics of a Turkish Lignite

ABSTRACT The most obvious disadvantage of lignites is high water content (25–65%). In this study, experiments were carried out to determine the mechanical dewatering characteristics of Konya Ilgın lignite, which has 8935 kJ/kg low heating value and 45.15% water content. The main parameters investigated in the dewatering experiments were water/dry lignite ratio, pressure, and duration of compression. The tests were carried out by varying time from 5 to 20 min and by varying pressure from 100 to 600 bar. Results showed that the dewatering rate increased with the increase of water/dry lignite ratio, pressure, and duration of compression. The increase was not linear and tend to decrease with an increase in each variable. Pressure was more effective than duration of compression for reducing final moisture content.
Identifying SUMO Protease Targets and Investigating E3 Ligase Interactions

Posttranslational modification by the Small Ubiquitin-like Modifier (SUMO) is a pervasive mechanism for controlling protein function. SUMO is conserved from yeast to man and is fundamental to eukaryotic life. Sumoylation is a dynamic process and regulation of SUMO conjugate levels is accomplished in two ways. First, SUMO can be removed from conjugate proteins by SUMO specific proteases. In budding yeast Saccharomyces cerevisiae, the SUMO protease Ulp1 is responsible for removing SUMO from target proteins and processing SUMO precursor peptides. Ulp1 is essential for cell cycle progression; however, few specific Ulp1 substrates have been identified. The first part of this thesis utilized a substrate-trapping mutant of Ulp1, known as the U-Tag, to identify candidate Ulp1 substrates. Our analysis has identified 32 candidate Ulp1 substrates includingBmhl, a regulatory molecule that interacts with the Anaphase Promoting Complex (APC). Bmh1 is a 14-3-3 protein that associates with an APC component and was previously shown to be sumoylated. These findings suggest a mechanism by which a SUMO protease can contribute to cell cycle regulation. The second method cells use to regulate SUMO conjugate levels is by destruction of sumoylated proteins in the ubiquitin proteasome system. Recent work has identified a novel class of SUMOTargeted Ubiquitin Ligases (STUbLs) which selectively ubiquitylatepolysumoylated proteins. In yeast, the STUbL heterodimer Slx5Slx8 has an important role in SUMO-targeted degradation. Slx5 is the targeting domain of the STUbL complex and it usually resides in the nucleus where it plays a key role in genome stability and DNA damage repair. Continuing work in the lab has identified a physical interaction between Slx5 and the E3 SUMO ligase known as Siz1. The data herein describes the functional consequences of this interaction and demonstrates that slx5A cells accumulate sumoylated and phosphorylated Siz1. These data suggestthat three different modifications are involved in Siz1 regulation (SUMO, ubiquitin, and phosphorylation). Finally, our data indicate that Siz1 is degraded in an Slx5 dependent manner when nuclear export is blocked during G2/M. In summary, part two of this thesis identifies targeting and localization domains in Slx5 and additionally provides evidence that STUbLs may regulate levels of an E3 SUMO ligase.
High-throughput Computational Study of Halide Double Perovskite Inorganic Compounds

Double perovskite halides are a class of materials with diverse chemistries that are amenable to solution-based synthesis routes, and display a range of properties for a variety of potential applications. Starting from a consideration of the octahedral and tolerance factors of ∼2000 candidate double perovskite compounds, we compute structural, electronic, and transport properties of ∼1000 using first-principles calculations based on density-functional-theory methods. The computational results have been assembled in a database that is accessible through the Materials Project online. As one potential application, double perovskites are candidates in the search for lead-free halide photovoltaic absorbers. We present the application of our database to aid the discovery of new double perovskite halide photovoltaic materials, by combining the results with optical absorption and phonon stability calculations. From three distinct classes of chemistries, 11 compounds were identified as promising solar absorbers an.