Miracle-dz/UniFAR-FTUs huggingface dataset:
Currículo ativo e a constituição de identidades profissionais em um curso de Licenciatura em Química

Este trabalho investigou os processos identitarios em construcao pelo curriculo ativo de um curso de Licenciatura em Quimica interpretando as percepcoes de seus diversos atores manifestadas atraves de seus discursos. Utilizou-se uma abordagem qualitativa em que os dados construidos foram submetidos a Analise Textual Discursiva. Eles apontaram que os licenciandos sao sujeitados a dois tipos distintos de identidades: em um polo estaria o quimico/o pesquisador em Quimica/o professor universitario e, no outro, estaria o professor da Educacao Basica/educador-pesquisador em Ensino de Quimica. Cada uma dessas identidades esta relacionada com categorias que emergiram claramente dos discursos de licenciandos, egressos e formadores. Sao elas, respectivamente, o “desvio bacharelizante da formacao” e o “estimulo do campo pedagogico”. Concluiu-se que ha uma contradicao parcial no curriculo ativo do curso, pois parte dos formadores trabalham sujeitando os licenciandos a uma carreira bacharelizante, enquanto outra parte busca estimula-los a carreira docente no ensino basico
Korean OBEsity Surgical Treatment Study (KOBESS): protocol of a prospective multicentre cohort study on obese patients undergoing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

Introduction Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery. Methods and analysis The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea. In total, 100 consecutive obese Asian patients who will undergo bariatric surgery will be recruited in 2016–2017; follow-up will be for 1 year. Primary outcomes are change in body weight and waist circumference at 1 year. All patients will undergo anthropometry, laboratory tests, bioelectrical impedance analysis, gastrofibroscopy, polysomnography and fat-measuring CT before and after surgery. Patients with diabetes will also undergo perioperative oral glucose tolerance and endocrinological hormone tests. Hypertensive patients will also undergo perioperative echocardiography and carotid Doppler ultrasonography. Female patients suspected of having polycystic ovarian syndrome will also undergo perioperative hormone tests and abdominal ultrasonography. Visceral and subcutaneous fat will be harvested during surgery. Blood, stool and urine samples will be taken at various perioperative time points. Although the cohort is small and the follow-up duration is relatively short, this study will determine whether bariatric surgery induces satisfactory weight loss in obese Koreans. Significantly, the tissue samples will also facilitate many studies examining the effects of bariatric surgery and their mechanisms. Ethics and dissemination Ethics approval was obtained from the institutional review board of each participating hospital. All findings arising from this cohort study will be published in open-access peer-reviewed journals and will be presented at national and international meetings. All KOBESS investigators will be able to propose research studies and potential publications based on KOBESS data and tissue samples. Trial registration number NCT03100292; Pre-results.
Circulating microRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer

Objective:The development of clinically validated biomarkers for cancer has remained an insurmountable task despite other advances in the field of cancer molecular biology. Mi(cro)RNAs have many characteristics of an ideal biomarker most notably their inherent stability and resilience. Recent blood-based miRNA profiling studies, reporting their presence in serum and plasma, have generated the concept that circulating miRNAs hold much potential as novel noninvasive biomarkers for cancer and other disease processes. The objective of this study was to investigate the potential of circulating microRNAs as novel breast cancer biomarkers. Methods:Using a novel approach to extract miRNAs from the circulation followed by real-time quantitative polymerase chain reaction analysis, levels of a panel of 7 candidate miRNAs were quantified in tissue and blood specimens of 148 patients with breast cancer and 44 age-matched and disease free control individuals. Results:We report that cancer-specific miRNAs were detected and significantly altered in the circulation of breast cancer patients, and that increased systemic miR-195 levels in breast cancer patients were reflected in breast tumors. Furthermore, we identified that circulating levels of miR-195 and let-7a decreased in cancer patients postoperatively, to levels comparable with control subjects, following curative tumor resection. Finally, we found that specific circulating miRNAs correlated with certain clinicopathological variables, namely nodal status and estrogen receptor status. Conclusion:These findings suggest that systemic miRNAs have potential use as novel breast cancer biomarkers and may prove useful in clinical management during the perioperative period.
Desenvolvimento de estratégias de intervenção psicológica para a cessação tabágica

O risco de doencas associado ao consumo de tabaco e actualmente um dos problemas mais importantes de saude publica. Para alem da dependencia fisiologica provocada pela nicotina, o consumo de tabaco tambem esta relacionado com variaveis psicossociais que reforcam e mantem o comportamento de fumar, tornando-o repetitivo e automatico nas mais diversas situacoes e contextos. Da maioria dos fumadores que desejam deixar de fumar sozinhos, so 5% tem exito. Nos ultimos tempos, tem-se verificado um aumento do numero de estrategias, farmacologicas, de substituicao e psicologicas, para fazer face a este problema. Dentro da ultima abordagem apresentam-se os primeiros dados deum programa de intervencao psicologica segundo o modelo proposto por E. Becona (1993) numa perspectiva cognitivo-comportamental. O protocolo de tratamento para deixar de fumar, inserido na Consulta de Psicologia Clinica do Hospital Pedro Hispano, compreende 3 fases (avaliacao, intervencao e seguimento) sendo composto por 6 sessoes de intervencao individual, ou em grupo, e 4 sessoes de acompanhamento. Os dados apresentados correspondem a uma amostra de 107 doentes. Dos doentes que completaram o tratamento,43% ficou abstinente e os restantes 57% reduziram o consumo de cigarros por dia e os niveis de nicotina de forma significativa. Estes dados apontam para a eficacia deste tipo de intervencao multicomponencial, que abrange nao so os aspectos fisiologicos do acto de fumar, mas tambem os seus aspectos comportamentais e psicossociais, pelo que se alerta para a pertinencia da divulgacao e expansao destes metodos de tratamento em servicos de saude na comunidade.
On the origin of cancer cells.

The article presents a summary of the current concept concerning the fundamental nature of cancer cells, and the steps which lead to their development, presently held by one of the world's outstanding enzymologists. Insight into the knowledge of the fundamental metabolic characteristics of cancer cells is provided. The potential, biologically utilizable energy production of cells is derived from 2 stable independent metabolic processes, respiration and anaerobic fermentation. Respiration is measured by the oxygen consumption of cells that are saturated with oxygen. Fermentation is measured by the formation of lactic acid in the absence of oxygen. Normal cells derive their energy primarily from respiration, and cancer cells primarily from fermentation. Cancer cells are considered to originate from normal cells in 2 phases. The first phase is an irreversible injury of respiration. All of the many carcinogenic agents produce their effect by an irreversible injury of respiration. The second phase in cancer formation is a result of a long struggle for existence by the injured cells to maintain their structure. As result of the morphological inferiority, based on obtaining energy from fermentation, the highly differentiated body cells are converted into undifferentiated cells that grow wildly. An outline of the evidence upon which this conception is based is provided. The use of pure strains of malignant cells in tissue culture in research concerning metabolism of these cells is outlined. These tissue cultures provide a new tool for the evaluation of chemotherapeutic agents.
Human parvovirus B19 in young male patients with hemophilia A: associations with treatment product exposure and joint range‐of‐motion limitation

BACKGROUND: To evaluate the risk of human parvovirus B19 (B19) transmission in recombinant antihemophilic factor, the seroprevalence among 798 two‐ to seven‐year‐old boys with hemophilia was compared. Also, data collected on joints were used to assess relations between B19 serostatus and joint range‐of‐motion (ROM) limitation.
Comparación del comportamiento en la red eléctrica del aerogenerador asincrónico de jaula de ardilla y el doblemente alimentado

En este articulo, se lleva a cabo un analisis comparativo entre estos dos tipos de aerogeneradores. La base para la comparacion es el comportamiento del generador en el sistema sujeto a diferentes tipos perturbaciones tales como: valles de tension, cortocircuitos, rachas de viento y cambios de carga.Para la simulacion se utiliza el SimPowerSystem del MATLAB. Sus ultimas versiones tienen entre sus herramientas modelos de turbinas y generadores eolicos que facilitan mucho el trabajo.En el caso de los Generadores Asincronicos con Rotor Jaula de ardilla se analizaron tanto el caso de Condensadores Variables en Paralelo como la utilizacion de Compensadores Estaticos de Reactivo. Esta ultima permite la regulacion de la tension en el punto de conexion del Aerogenerador. Finalmente, queda demostrada y bien argumentada en el trabajo la superioridad del generador doblemente alimentado. Palabras claves: aerogeneradores, generadores asincronicos de jaula, generadores doblemente alimentado
Women's sexual pain disorders.

INTRODUCTION Women's sexual pain disorders include dyspareunia and vaginismus and there is need for state-of-the-art information in this area. AIM To update the scientific evidence published in 2004, from the 2nd International Consultation on Sexual Medicine pertaining to the diagnosis and treatment of women's sexual pain disorders. METHODS An expert committee, invited from six countries by the 3rd International Consultation, was comprised of eight researchers and clinicians from biological and social science disciplines, for the purpose of reviewing and grading the scientific evidence on nosology, etiology, diagnosis, and treatment of women's sexual pain disorders. MAIN OUTCOME MEASURE Expert opinion was based on grading of evidence-based medical literature, extensive internal committee discussion, public presentation, and debate. Results. A comprehensive assessment of medical, sexual, and psychosocial history is recommended for diagnosis and management. Indications for general and focused pelvic genital examination are identified. Evidence-based recommendations for assessment of women's sexual pain disorders are reviewed. An evidence-based approach to management of these disorders is provided. CONCLUSIONS Continued efforts are warranted to conduct research and scientific reporting on the optimal assessment and management of women's sexual pain disorders, including multidisciplinary approaches.
Optimization of thickness and shape of core block in resonator for 7 kW-class wireless power transfer system for PHEV/EV charging

Transmitting and receiving resonators for 7 kW-class wireless power transfer/transmission (WPT) systems operating at 85 kHz have been developed for contactless Electric Vehicle (EV)/Plugin Hybrid EV (PHEV) charging. The light weight and small volume of the on-board receiving resonator to be mounted on the vehicle are required attributes. A thickness and a shape of the core in the resonance coil are optimized considering a coil weight, a core loss and a coupling coefficient between the resonators. The coupling coefficient and a coil loss included the core loss of the on-board prototype resonator with the core weight of 4.3 kg and a size of 600 mm by 400 mm are measured for 7 kW-class WPT system. Coil-to-coil power efficiency at the rated transfer power can be estimated with high accuracy by evaluating the core loss. The coil-to-coil efficiency of 93.8% at 160-mm air gap is achieved for the prototype resonator to be mounted on the vehicle.
Work organization and patient care staff injuries: the impact of different care models for "alternate level of care" patients.

BACKGROUND The number of elderly patients who do not have acute-care needs has increased in many North American hospitals. These alternate level care (ALC) patients are often cognitively impaired or physically dependent. The physical and psychosocial demands on caregivers may be growing with the increased presence of ALC patients leading to greater risk for injury among staff. METHODS This prospective cohort study characterized several models for ALC care in four acute-care hospitals in British Columbia, Canada. A cohort of 2,854 patient care staff was identified and followed for 6 months. The association between ALC model of care and type and severity of injury was examined using multinomial and ordinal logistic regression. RESULTS Regression models demonstrated that the workers on ALC/medical nursing units with "high" ALC patient loads and specialized geriatric assessment units had the greatest risk for injury and the greatest risk for incurring serious injury. Among staff caring for ALC patients, those on dedicated ALC units had the least risk for injury and the least risk for incurring serious injury. CONCLUSIONS The way in which ALC care is organized in hospitals affects the risk and severity of injuries among patient care staff.
A cis-Acting Regulatory Variant in the IL2RA Locus1

The mechanism for the association of type 1 diabetes (T1D) with IL2RA remains to be clarified. Neither of the two distinct, transmission-disequilibrium confirmed loci mapping to this gene can be explained by a coding variant. An effect on the levels of the soluble protein product sIL-2RA has been reported but its cause and relationship to disease risk is not clear. To look for an allelic effect on IL2RA transcription in cis, we examined RNA from 48 heterozygous lymphocyte samples for differential allele expression. Of the 48 samples, 32 showed statistically significant allelic imbalance. No known single nucleotide polymorphism (SNP) had perfect correlation with this transcriptional effect but the one that showed the most significant (p = 1.6 × 10−5) linkage disequilibrium with it was the SNP rs3118470. We had previously shown rs3118470 to confer T1D susceptibility in a Canadian dataset, independently of rs41295061 as the major reported locus (p = 5 × 10−3, after accounting for rs41295061 by conditional regression). Lower IL2RA levels consistently originated from the T1D predisposing allele. We conclude that an as yet unidentified variant or haplotype, best marked by rs3118470, is responsible for this independent effect and increases T1D risk through diminished expression of the IL-2R, likely by interfering with the proper development of regulatory T cells.
Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes.

The SON gene, which maps to human chromosome 21q22.1-q22.2, encodes a novel regulatory protein. Here we describe the organization of the Son locus in the mouse genome. The mouse Son gene spans a region of approximately 35 kb. The coding region is more than 8 kb in length and has been completely sequenced. The gene is organized into 11 coding exons and 1 noncoding 3'UTR exon, with over 70% of the coding region residing in one 5.7-kb exon. The gene contains at least one alternative exon, N/C exon 1, which can be used, by splicing, to generate a truncated form of the SON protein. Further investigation of the mouse Son locus has identified the genes directly flanking Son. The glycinamide ribonucleotide formyltransferase gene, Gart, is encoded 5' of Son in a head-to-head arrangement, with the start of both genes lying within 899 bp. Sequence comparison with the expressed sequence tagged database identified a novel gene within 65 bp of the 3' end of Son, which we have named Donson. In this unusually compact gene cluster, we have found overlap in the pattern of expression between Gart, Son, and Donson. However, at least two of these genes have very different functions. While GART is involved in purine biosynthesis, we find that SON shows the characteristics of "SR- type" proteins, which are involved in mRNA processing and gene expression.
Do smokers know how to quit? Knowledge and perceived effectiveness of cessation assistance as predictors of cessation behaviour.

AIMS Despite the existence of effective cessation methods, the vast majority of smokers attempt to quit on their own. To date, there is little evidence to explain the low adoption rates for effective forms of cessation assistance, including pharmaceutical aids. This study sought to assess smokers' awareness and perceived effectiveness of cessation methods and to examine the relationship of this knowledge to cessation behaviour. DESIGN A random-digit-dial telephone survey (response rate = 76%) with 3-month follow-up was conducted with 616 adult daily smokers in South-Western Ontario, Canada. MEASUREMENTS A baseline survey assessed smoking behaviour, as well as smokers' awareness and perceived effectiveness of cessation assistance. A follow-up survey measured changes in smoking behaviour and adoption of cessation assistance at 3 months. FINDINGS Participants demonstrated a poor recall of cessation methods: 45% of participants did not recall nicotine gum, 33% did not recall the nicotine patch and 57% did not recall bupropion. Also, many participants did not believe that the following cessation methods would increase their likelihood of quitting: nicotine replacement therapies (36%), bupropion (35%), counselling from a health professional (66%) and group counselling/quit programmes (50%). In addition, 78% of smokers indicated that they were just as likely to quit on their own as they were with assistance. Most important, participants who perceived cessation methods to be effective at baseline, were more likely to intend to quit (OR = 1.80, 95% CI: 1.12-2.90), make a quit attempt at follow-up (OR = 1.80, 95% CI: 1.03-3.16) and to adopt cessation assistance when doing so (OR = 3.62, 95% CI: 1.04-12.58). CONCLUSIONS This research suggests that many smokers may be unaware of effective cessation methods and most underestimate their benefit. Further, this lack of knowledge may represent a significant barrier to treatment adoption.
Telic verbs in early Catalan

Abstract This article focuses on child speech sequences which diverge from their corresponding adult counterparts in terms of the order of their constituents. Adult Catalan does not allow neutral preverbal objects whereas early Catalan seems to allow objects preceding verbs in the very early stages. We analyse the OV sequences found in our data and show how these only show up co-occuring with a certain type of verbs, namely, ‘telic’ verbs. In line with this observation we propose that aspect is a crucial feature of these sequences projecting whenever one of these verbs is selected and providing a landing site for object movement. Another part of the analysis of the OV constructions implies noticing that the morphological make-up of the verbal elements is not always non-finite. The alternation that we observe between VO-OV constructions seems to be determined by the verb type but it is only fully accounted for if we allow for a framework in which the AGR parameter is not yet set. This possibility follows from the bilingualism proposal in Roeper (1999) where child language permits different grammars to co-exist in a particular stage. In the case under consideration the AGR feature would be allowed to have two values and thus the verb would not raise obligatorily.
Effective Interactions, Structure, and Phase Behavior of Lightly Tethered Nanoparticles in Polymer Melts

We have generalized the microscopic polymer reference interaction site model (PRISM) theory to study the structure and phase behavior of polymer-tethered spherical nanoparticles in a dense homopolymer melt. In the absence of a polymer matrix, fluids of such hybrid nanoparticles show strong concentration fluctuations indicative of aggregate formation and/or a tendency for microphase separation as the total packing fraction and/or nanoparticle attraction strength increase. In the presence of a polymer matrix, there is a competition between tether-mediated microphase separation and matrix-induced macrophase separation. For a single tether of eight segments on a nanoparticle twice the diameter of a segment, the apparent microphase spinodal curve exhibits both dilution-like and depletion-like features and a nonmonotonic dependence of the spinodal temperature on matrix chain length. As the particle size and tether length are both increased, such that the total space filling volume of the tether continues to equ.
La radiología convencional en la coxartrosis

La radiologia es una disciplina la cual en los ultimos anos ha conseguido progresos espectaculares. Asi mismo la introduccion de nuevas tecnicas de imagen como son la tomografia computada (TC) con su variante tridimensional (3D) y demas tecnicas actuales. Sin embargo la raRESUMEN. Introduccion: Desde la aparicion de los rayos X el diagnostico en musculo esqueletico dio un giro nunca antes imaginado y en los ultimos anos se han mejorado las tecnicas de la radiologia, sin embargo, la radiologia simple sigue siendo tan importante que aun no encuentra desplazamiento alguno en el arsenal del diagnostico ortopedico. Objetivo: Presentar las diferentes posiciones y proyecciones del paciente con artrosis de cadera para su mejor identificacion radiologica de esta patologia. Resultados: Se encontraron seis diferentes proyecciones utiles para el diagnostico y tratamiento en la coxartrosis en donde se menciona la posicion correcta del paciente. Discusion: Es muy importante saber y conocer las diferentes proyecciones y sobre todo la posicion en la que se debe de colocar al paciente para la buena imagen que debemos obtener para la elaboracion de un diagnostico radiologico correcto.
Testosterone, androstenedione and dehydroepiandrosterone in plasma during pregnancy and at delivery: concentration and protein binding.

ABSTRACT Pregnancy produces a significant (p <0.01) increase in the concentration of testosterone (T) in plasma (nonpregnant females 49 ±13; pregnant females 114 ±38 mμg/100 ml), a nonsignificant increase in the androstenedione (A) concentration (nonpregnant 181 ±59; pregnant 249 ±82 mμg/100 ml) and a nonsignificant decrease in the dehydroepiandrosterone (D) concentration (nonpregnant 502 ±88; pregnant 363 ±233 mμg/100 ml). There was no correlation between fetal sex and maternal concentration of T and D. Mothers bearing a male fetus tended to have Δ values higher than those of mothers bearing a female fetus; the difference, however, was not significant. At delivery, the plasma concentrations of Δ and D were significantly higher than those during pregnancy, while the plasma concentration of T was similar. In every instance, the concentrations of T, Δ and D in the plasma of cord vein were lower than those of the corresponding maternal plasma. There was no correlation between the sex of the newborn and the c.