Miracle-dz/UniFAR-FTUs huggingface dataset:
Cross-Language Automatic Plagiarism Detector Using Latent Semantic Analysis and Self-Organizing Map

Computer assisted detection or automatic detection for plagiarism could help human to check whether an author of a paper do plagiarism or not. Department of Electrical Engineering, Universitas Indonesia had been developing cross-language automatic plagiarism detection which test paper is written on Indonesian and reference paper written on English. More accurate automatic detection system is needed to prevent plagiarism act, especially on academic paper. The system is based on Latent Semantic Analysis (LSA) algorithm with addition of Self-Organizing Map (SOM) to do classification of the output from LSA. Some features for SOM are extracted from singular value matrix from LSA, they are Frobenius Norm and Cosine Similarity. Together with percentage of technical term, all of the features are used as the input for SOM to classify into 10, 5, 3, and 2 classes. The use of 5 classes in LSA could give equal accuracy for all classes, with the highest accuracy reach 83.09%. While in LSA-SOM, the best accuracy is 83.53% for training data and 80.47% for testing data, in 2-classes configuration with 3 features, they were percentage of technical term, frobenius norm, and pad.
miR-34b/c rs4938723 T>C Decreases Neuroblastoma Risk: A Replication Study in the Hunan Children

Neuroblastoma is the most common seen solid neural tumor in children less than age one. As mutation in the miR-34b/c gene is observed in several types of human malignancies, there likely to be similar events that contribute to the pathogenesis of neuroblastoma. We hypothesize that polymorphism in the miR-34b/c gene might predispose to neuroblastoma. Here, we conducted this replication study by genotyping rs4938723 T>C from miR-34b/c in Hunan children (162 subjects with neuroblastoma and 270 control subjects) and examined its effect on the risk of neuroblastoma. We determined such association using logistic regression, adjusted for age and gender. Relative to those with TT genotype, subjects with C allele had reduced neuroblastoma risk (TC vs. TT: adjusted OR = 0.46, 95%CI = 0.30‐0.71; additive model: adjusted OR = 0.64, 95%CI = 0.47‐0.88; TC/CC vs. TT: adjusted OR = 0.49, 95%CI = 0.33‐0.73). Stratified analysis revealed that rs4938723 TC/CC carriers were less likely to develop neuroblastoma for patients in the subgroups of age ≤ 18 months, age > 18 months, females, males, tumors in retroperitoneal, tumors in other sites, and clinical stages II, III, IV, and III+IV. Our findings verified miR-34b/c rs4938723 C variant allele as a protective factor for the risk of neuroblastoma. Further investigation of how miR-34b/c rs4938723 T>C might modify neuroblastoma risk is warranted.
Modelization of Energy in WSN basing on LEACH Protocol and Polynomial Model

Recently, because of limited power in wireless sensor networks (WSNs), many of hierarchical routing protocols have been proposed as an efficient mechanism for reducing energy. The most popular one is LEACH for "Low Energy Adaptive Clustering hierarchy". Depending on multiple and complicated tasks, sensor nodes can't survive longer and die after a duration due to the scarce of energy provided by a battery. So, piloting the entire sensor networks with limited resources of energy is a big challenge due to the diversity of factors that impact energy. In this contest and basing on the LEACH protocol, we have modelized and optimized some aspects of energy in WSN using a design of experiment strategy. Indeed, basing on the power of polynomial equations drawn from the limited development of Taylor-Mac Laurin, we have optimized and explained perfectly some energetic phenomena in wireless sensor networks.
Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure

Endothelial cells are, by number, one of the most abundant cell types in the heart and active players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in maintaining cardiac vascularization and perfusion during physiological and pathological hypertrophy. On the other hand, a reduction in cardiac capillary density with subsequent tissue hypoxia, cell death and interstitial fibrosis contributes to the development of contractile dysfunction and heart failure, as suggested by clinical as well as experimental evidence. Although the molecular causes underlying the inadequate (with respect to the increased oxygen and energy demands of the hypertrophied cardiomyocyte) cardiac vascularization developing during pathological hypertrophy are incompletely understood. Research efforts over the past years have discovered interesting mediators and potential candidates involved in this process. In this review article, we will focus on the vascular changes occurring during cardiac hypertrophy and the transition toward heart failure both in human disease and preclinical models. We will summarize recent findings in transgenic mice and experimental models of cardiac hypertrophy on factors expressed and released from cardiomyocytes, pericytes and inflammatory cells involved in the paracrine (dys)regulation of cardiac angiogenesis. Moreover, we will discuss major signaling events of critical angiogenic ligands in endothelial cells and their possible disturbance by hypoxia or oxidative stress. In this regard, we will particularly highlight findings on negative regulators of angiogenesis, including protein tyrosine phosphatase-1B and tumor suppressor p53, and how they link signaling involved in cell growth and metabolic control to cardiac angiogenesis. Besides endothelial cell death, phenotypic conversion and acquisition of myofibroblast-like characteristics may also contribute to the development of cardiac fibrosis, the structural correlate of cardiac dysfunction. Factors secreted by (dysfunctional) endothelial cells and their effects on cardiomyocytes including hypertrophy, contractility and fibrosis, close the vicious circle of reciprocal cell-cell interactions within the heart during pathological hypertrophy remodeling.
Long-Lasting Response Changes in Deep Cerebellar Nuclei in vivo Correlate With Low-Frequency Oscillations

The deep cerebellar nuclei (DCN) have been suggested to play a critical role in sensorimotor learning and some forms of long-term synaptic plasticity observed in vitro have been proposed as a possible substrate. However, till now it was not clear whether and how DCN neuron responses manifest long-lasting changes in vivo. Here, we have characterized DCN unit responses to tactile stimulation of the facial area in anesthetized mice and evaluated the changes induced by theta-sensory stimulation (TSS), a 4 Hz stimulation pattern that is known to induce plasticity in the cerebellar cortex in vivo. DCN units responded to tactile stimulation generating bursts and pauses, which reflected combinations of excitatory inputs most likely relayed by mossy fiber collaterals, inhibitory inputs relayed by Purkinje cells, and intrinsic rebound firing. Interestingly, initial bursts and pauses were often followed by stimulus-induced oscillations in the peri-stimulus time histograms (PSTH). TSS induced long-lasting changes in DCN unit responses. Spike-related potentiation and suppression (SR-P and SR-S), either in units initiating the response with bursts or pauses, were correlated with stimulus-induced oscillations. Fitting with resonant functions suggested the existence of peaks in the theta-band (burst SR-P at 9 Hz, pause SR-S at 5 Hz). Optogenetic stimulation of the cerebellar cortex altered stimulus-induced oscillations suggesting that Purkinje cells play a critical role in the circuits controlling DCN oscillations and plasticity. This observation complements those reported before on the granular and molecular layers supporting the generation of multiple distributed plasticities in the cerebellum following naturally patterned sensory entrainment. The unique dependency of DCN plasticity on circuit oscillations discloses a potential relationship between cerebellar learning and activity patterns generated in the cerebellar network.
Improved read/write cost tradeoff in DNA-based data storage using LDPC codes

With the amount of data being stored increasing rapidly, there is significant interest in exploring alternative storage technologies. In this context, DNA-based storage systems can offer significantly higher storage densities (petabytes/gram) and durability (thousands of years) than current technologies. Specifically, DNA has been found to be stable over extended periods of time which has been demonstrated in the analysis of organisms long since extinct. Recent advances in DNA sequencing and synthesis pipelines have made DNA-based storage a promising candidate for the storage technology of the future. Recently, there have been multiple efforts in this direction, focusing on aspects such as error correction for synthesis/sequencing errors and erasure correction for handling missing sequences. The typical approach is to use separate codes for handling errors and erasures, but there is limited understanding of the efficiency of this framework. Furthermore, the existing techniques use short block-length codes and heavily rely on read consensus, both of which are known to be suboptimal in coding theory. In this work, we study the tradeoff between the writing and reading costs involved in DNA-based storage and propose a practical scheme to achieve an improved tradeoff between these quantities. Our scheme breaks with the traditional separation framework and instead uses a single large block-length LDPC code for both erasure and error correction. We also introduce novel techniques to handle insertion and deletion errors introduced by the synthesis process. For a range of writing costs, the proposed scheme achieves 30-40% lower reading costs than state-of-the-art techniques on experimental data obtained using array synthesis and Illumina sequencing. The code, data, and Supplementary Material is available at https://github.com/shubhamchandak94/LDPC_DNA_storage.
Assessment of the Live Attenuated and Wild-Type Edwardsiella ictaluri-Induced Immune Gene Expression and Langerhans-Like Cell Profiles in the Immune-Related Organs of Catfish

Edwardsiella ictaluri is a Gram-negative intracellular pathogen that causes enteric septicemia of catfish (ESC). Successful vaccination against intracellular pathogens requires T cell priming by antigen presenting cells (APCs) that bridge innate and adaptive immunity. However, the evidence on immunological mechanisms that underscore E. ictaluri pathogenesis and the protective role of live attenuated vaccines (LAVs) is scarce. We assessed the expression of immune genes related to antigen presentation by real-time PCR and the distribution patterns of Langerhans-like (L/CD207+) cells by immunohistochemistry in the immune-related tissues of channel catfish challenged with two novel E. ictaluri LAVs, EiΔevpB, and ESC-NDKL1 and wild type (WT) strain. Our results indicated significantly elevated expression of IFN-γ gene in the anterior kidney (AK) and spleen of vaccinated catfish at the early stages of exposure, which correlated with increased numbers of L/CD207+ cells. In general, the ESC-NDKL1-induced IFN-γ gene expression patterns in the AK resembled that of the patterns induced by EiΔevpB. However the MHCII gene expression patterns differed between the strains with significant increases at 6 h post-challenge (pc) with the EiΔevpB and at 7 d pc with the ESC-NDKL1 strains, respectively. Significant increases in activity of T helper type polarization genes such as IFN-γ and T cell co-receptors after exposure to ESC-NDKL1, in combination with elevated numbers of L/CD207+ cells at 7 d pc with both LAVs compared to uninfected and the WT-exposed counterparts, were documented in the spleen. The dominant pro-inflammatory environment with dramatically overexpressed inflammatory genes in the AK and 7 d pc in the spleen in response to E. ictaluri was found in exposed catfish. In general, the pro-inflammatory gene expression profiles in the ESC-NDKL1 pc showed more similarities to the WT strain-induced gene profiles compared to the EiΔevpB counterpart. In addition, E. ictaluri WT significantly decreased the numbers of Langerhans-like L/CD207+ cells in the AK and spleen at 3 and 7 days pc. In conclusion, we report the differential framework of initiation of innate and adaptive immune responses between E. ictaluri strains with both LAVs having a potential of satisfying the stringent requirements for successful vaccines.
Effects of Mindfulness-Based Positive Behavior Support (MBPBS) Training Are Equally Beneficial for Mothers and Their Children With Autism Spectrum Disorder or With Intellectual Disabilities

Parenting a child with autism spectrum disorder (ASD) or intellectual disabilities (IDs) can be stressful for many parents. Mindfulness-Based Positive Behavior Support (MBPBS) is a customized mindfulness program that enables parents and other caregivers to reduce their perceived psychological stress to normative levels through mindfulness procedures and to support children with ASD or ID to self-manage their challenging behaviors through positive behavior support (PBS). In this study, we evaluated whether MBPBS would have differential effects on the stress levels of mothers of adolescents with ASD (n = 47) or with ID (n = 45) and the effects of the program on the aggressive, disruptive, and compliance behaviors of their children. Both groups of mothers participated in the 40-week study (10 weeks control and 30 weeks MBPBS program), rated their own stress levels, and collected daily observational data on the adolescents’ behavior. Results showed significant reductions in the level of stress in both groups of mothers, but no differential effects on mothers of children with ASD or with ID. In addition, significant reductions in aggression and disruptive behavior and increases in compliance behaviors were observed in the adolescents in both groups. The results suggest that MBPBS is equally beneficial for mothers of adolescents with ASD or ID. In the present study, although the mothers of children with ID had slightly higher levels of stress at baseline and mothers of children with ASD had lower levels of stress following the MBPBS program, the program can be considered equally effective in reducing the stress levels of both groups of mothers. This suggests that the program may be effective regardless of baseline levels of mothers’ stress.
Behavioral Diversity Across Classic Rodent Models Is Sex-Dependent

Symptoms of trauma and stressor related disorders such as post-traumatic stress disorder (PTSD) often develop well after the traumatic experience has occurred, and so identifying early predictors of risk or resilience is important for the implementation of interventional therapies. For example, passive coping strategies such as tonic immobility and peritraumatic dissociation during the trauma itself are risk factors for the developments of PTSD, especially in women. However, discrete, sex-specific coping responses that predict later outcomes in animal models have not been rigorously defined. Recently, we identified an active, escape-like response exhibited primarily by a subset of female rats in a classic auditory fear conditioning task (“darting”). Here, we asked whether darting during conditioning predicted active responding in a single forced swim (SFS) session to study the potential for darting to reflect a trait-like behavioral strategy that translated across stress models. Male and female Sprague-Dawley (SD) rats were tested in auditory fear conditioning acquisition and memory tests to identify Darters, and then a 15-min SFS 2 weeks later. We observed a significant effect of sex in conditioned freezing behavior, with males exhibiting greater freezing than females across conditioning and testing trials in comparison to females. However, females demonstrated higher velocities in response to shock presentations, and were more likely to exhibit darting behavior in response to the conditioned stimulus (CS). In SFS measures, females engaged in active behaviors such as climbing, head shaking, and diving in greater proportions than males, while males spent more time immobile throughout testing. Despite females exhibiting a more diverse behavioral repertoire in both tests, Darters did not differ from Non-darters in any SFS measure. These results suggest that the propensity to dart does not reflect a simple hyperactivity, and that despite conceptual overlap across the two tests (inescapable stress exposure and the ability to measure active vs. passive coping), the behavioral strategies engaged by an individual animal in each are likely driven by discrete mechanisms. We discuss potential challenges in interpretation of standard behavioral outcomes in classic models across the sexes, and consider the potential need for novel models that better tap into motivational states in females.
Application of Nutrigenomics for Milk Fat Improvement in Dairy Cattle

Nutrigenomics that is the study of interaction between dietary components and the genome, and the regulating changes in proteins and other metabolism. The development of nutrigenomic studies has brought about a number of new research tools. Bioinformatics are now making their ways to solve the intervening puzzle between nutrient and genes. Numerous dietary components can alter genetic events, and thereby influence health. In addition to the essential nutrients, such as carbohydrates, amino acids, fatty acids, calcium, zinc, selenium, and vitamin A, C and E, there is a variety of nonessential bioactive components that seem to significantly influence health.
Land Use Guidelines to Maintain Habitat Diversity of Wood- Pastures in the Southern Carpathians Under Projected Climate Change

The biodiversity of wood-pastures depends on a balance between human interference and natural vegetation succession, which however is undergoing changes driven by socio-economic factors and climate change. Widely spread throughout Europe, wood-pastures were subject to either intensification or abandonment, leading to habitat segregation and loss. This is currently the fate of large Romanian remnant woodpastures and climate warming further complicates management adaptation.In a series of simulation experiments, we compared the long-term effects of different land use and climate change scenarios on the habitat diversity of a wood-pasture in the Southern Carpathians (Fundata village, Romania). We tested livestock densities according to management guidelines, complemented with shrub-cutting in order to maintain a structurally-diverse landscape with high habitat values in the light of climate change. We found that significant losses of open pastureland and inclusion into forest, as well as landscape structural simplification and loss of complex habitats can be expected from climate warming, with more severe consequences in a hotter climate perspective. We arguefor the re-establishment of the traditional multi-use of wood-pastures at optimum livestock densities in combination with low-intensity shrubcutting, because our study demonstrated that traditional practices offer a balanced compromise between agricultural use and maintaining habitat mosaics that are robust to climate change.
Flap-Footed Lizards (Gekkota: Pygopodidae) Have Forelimbs, Albeit During Embryonic Development

Abstract. Limb reduction among squamate clades is common; limbless (forelimbs, hindlimbs, or both) forms have had at least 25 independent origins among snakes and lizards. The general evolutionary pattern is the gradual loss of limb elements proceeding from the toes to the shoulder or hip. In contrast, forelimbs are not known to have ever existed in snakes. Forelimbs are not known for either stem or crown snakes; snake fossils lack forelimbs and the embryos of modern snakes lack the signaling pathways that initiate forelimb development. Both fossil and developmental data thus imply an abrupt loss of forelimbs. In contrast, the well-developed hindlimbs of the oldest fossil snakes and vestigial hindlimbs of some basal clades of modern snakes imply the historical presence of hindlimbs, and their gradual reduction during snake evolution. In contrast, observations on limb-reduced lizards are in accord with gradual reduction of both fore- and hindlimbs; embryos of even limbless species initiate limb development. The question then arises, have any clades of limbless lizards become limbless abruptly, as have snakes? To address this question, I examined limb development in the family Pygopodidae. Like basal snakes, pygopodids are characterized by the absence of forelimbs and by vestigial hindlimbs. My observations on the development of forelimb buds in Delma molleri support gradual limb reduction, as do observations on other limbless lizards. Nonetheless, many clades of limbless lizards are yet to be studied and hence provide a wealth of opportunities to address modes of limb reduction and loss in squamate reptiles.
Assessment of emphysema in patients undergoing major lung resections.

Despite the advances in surgical techniques and the perioperative care, prolonged air leak (PAL) after major lung resection is still a frequent and vexing postoperative complication that all thoracic surgeons face in their daily practice (1). PAL is a common complication that occur in 8% to 15% of all lung resections (2), that may increase hospital stay, increase the risk of empyema, cardiopulmonary complications (3) and as a consequence increase costs (4).
Oenothera resicum (Onagraceae), a new species and the first record of the family from the Revillagigedo Archipelago, Mexico

Oenothera resicum (Onagraceae) is here described and illustrated. This is the first record of the Onagraceae family in the Revillagigedo Archipelago, Mexican Pacific. The new species, presently known only from Isla Clarión, has characteristic features of species of subsect. Raimannia, from which can be differentiated by its perennial habit, glabrescent large fruits, glabrous sepals, conspicuously dentated leaves, stigma surrounded by the anthers at anthesis, basal rosette absent, and its particular ecological habitat. The species description, ecological information, habitat and conservation assessment are also discussed. Additionally, a key for the species of subsect. Raimannia distributed in Mexico is provided.
Integrated management of tortricid pests of tree fruit

A group of relatively small moths in the family Tortricidae is commonly the most destructive insect pests of deciduous tree fruits throughout the world (van der Geest and Evenhuis 1991). Within each geographical area there is typically a defined group of tortricids. This group can include key species whose larvae feed on fruit, externally or internally, and which drives the entire seasonal pest management programme, and any number of external feeders whose larvae may cause sporadic fruit injury and require occasional management. Successful control of tortricids can have a significant impact on the global trade of tree fruits and various phytosanitary regulations are in place to counter their accidental introduction into new areas. This chapter summarizes the recent literature associated with several applied aspects of tortricid management.