Miracle-dz/UniFAR-FTUs huggingface dataset:
A retrospective study of hemodialysis treated end-stage renal disease patients with renal osteodystrophy-associated fragility fractures

Background: Nephropathy associated metabolic disorder induces high incidence of fragility fracture in end-stage renal disease (ESRD) patients. As the risk factors and prognosis of fragility fracture in ESRD patients are unclear, more research is needed. This study aimed to evaluate various risk factors for ESRD-related fragility fractures, explore factors affecting the prognosis of patients with such fractures, and provide information for prevention and treatment of renal osteopathy to improve the prognosis of patients.Methods: In this retrospective case-control study, the case notes of 521 ESRD patients who received maintenance dialysis for at least 3 months were examined. Finally, 44 patients diagnosed with fragility fractures were assigned to the fragility fracture (FF) group and 192 patients were included in the control group (CG). Demographic information, underlying diseases, nutritional, bone metabolism, and renal function parameters, along with the number and causes of any deaths, were recorded for multiple statistical analysis.Results: The FF group had increased incidences of essential hypertension and diabetes mellitus and higher serum calcium, corrected calcium, alkaline phosphatase, and hemoglobin levels. Immunoreactive parathyroid hormone (iPTH), total cholesterol (TC), and low density lipoprotein (LDL) levels were higher in the CG.Conclusions: Essential hypertension and diabetes, high serum calcium and alkaline phosphatase levels, and reduced iPTH levels were risk factors for fragility fracture in ESRD patients. Maintaining iPTH and serum TC levels may protect against fragility fractures in them. Fragility fractures may yield poor prognosis and shorter lifespan. The presence of fragility fracture was an independent predictor of all-cause death in ESRD patients.
The Chemistry Of Heterocyclic Compounds Thiophene And Its Derivatives

the chemistry of heterocyclic compounds thiophene and its derivatives are a good way to achieve details about operating certainproducts. Many products that you buy can be obtained using instruction manuals. These user guides are clearlybuilt to give step-by-step information about how you ought to go ahead in operating certain equipments. Ahandbook is really a user's guide to operating the equipments. Should you loose your best guide or even the productwould not provide an instructions, you can easily obtain one on the net. You can search for the manual of yourchoice online. Here, it is possible to work with google to browse through the available user guide and find the mainone you'll need. On the net, you'll be able to discover the manual that you might want with great ease andsimplicity
Model School Well-Being Sebagai Tatanan Sekolah Sejahtera Bagi Siswa

Sekolah merupakan elemen penting dalam proses perkembangan individu karena berfungsi pemilihan karir di masa mendatang dan merupakan sarana pembelajaran mengenai pengetahuan tentang peran sosial dan batasan norma. Implementasi sekolah yang baik bagi siswa masih perlu dievaluasi. Hal ini berdasarkan adanya ketidaksejahteraan yang dialami oleh remaja, yang berkaitan dengan adanya kasus kekerasan yang terjadi di sekolah. Menindaklanjuti berbagai fenomena tersebut maka sekolah perlu menciptakan atmosfir yang positif bagi perkembangan siswa. Tujuan artikel ini adalah mengkaji model kesejahteraan psikologis dengan konsep school well-being. School well-being merupakan penilaian subjektif individu terhadap sekolahnya dalam memuaskan kebutuhan individu yang terdiri dari empat aspek yaitu having (kondisi sekolah), loving (hubungan sosial), being (pemenuhan diri), dan health (kesehatan). Faktor-faktor yang mempengaruhi school well-being yaitu hubungan sosial, kontrol dan optimisme, teman dan waktu luang, volunteering, peran sosial, karakteristik kepribadan dan tujuan serta aspirasi. School well-being memberikan peranan untuk mengembangkan sikap positif selama proses belajar, dan dapat meningkatkan prestasi akademik serta menekankan pada pentingnya kesehatan mental siswa.
Measurements of concentration, 13 C/ 12 C and 18 O/ 16 O ratios of tropospheric carbon dioxide over Switzerland

In 1982, we collected air sample profiles approximately monthly from aircraft at altitudes up to about 7 km and analyzed them for CO 2 concentration and stable isotope composition. The following seasonally detrended mean values were obtained per 1 January, 1982: 338 ppm, δ 13 C=-7.72‰, δ 18 O = -0.6‰ (versus PDB); isotopic results are corrected for N 2 0 contribution. CO 2 results are discussed in terms of vertical eddy diffusion and of a mean annual vertical flux. Assuming a two-component mixture between background air and biospheric CO 2 , δ 13 C of the biospheric component is -26.2‰, in good agreement with other northern hemisphere results. δ 18 O varies seasonally, but with relatively much scatter. The oxygen isotopic composition of CO 2 is determined by exchange with vegetation, soils and ocean; these processes are discussed in detail. DOI: 10.1111/j.1600-0889.1987. tb00272.x
A Steady Transonic Linear Cascade for True Scale Cooling Measurements

The design and benchmarking measurements for a steady, transonic linear cascade for film cooled airfoils are presented. The facility holds up to 11 true scale turbine airfoils with high span to chord ratio for two-dimensional flow at the airfoil midspan. Mainstream air is continuously supplied by a compressor, while desiccant dried air is used as the cooling flow to match coolant-to-mainstream density ratios. The cooling system supplies three airfoils, each with independent circuits, to enable parametric studies of cooling with periodicity for central airfoils. Independent Mach and Reynolds number control at steady conditions is achieved by using control valves and a bypass loop. Incidence angle studies can be performed by using a turntable and modular guide wall system. Optical windows include a zinc selenide window for spatially resolved surface temperature measurements using infrared thermography, as well as glass windows for flowfield measurements using laser-based diagnostics. The infrared camera setup enables a 360 degree view around the surface of the central airfoil. For laser-based diagnostics, laser sheets can be delivered to the central airfoil through glass inserts in the guidewalls. Current benchmarking results include static pressures on the blade surface and endwall, inlet boundary layer, and freestream turbulence measurements at various Mach numbers, Reynolds numbers, and incidence angles. Results indicate excellent periodicity over a wide range of conditions. Near term work in the facility will investigate film cooling at transonic conditions for a representative modern blade geometry.
Effectiveness of single application alcohol based antiseptic solution in preventing surgical site infection

Background: Surgical site infections are the most commonly encountered problem in all surgical procedure. The main aim of the study is finding out the effectiveness of single application alcohol based antiseptic solution during preoperative preparation to reduce the surgical site infections. Materials and Methods: It is a prospective study of patients who underwent major and minor procedure in the duration of August 2019 December 2019. The primary outcome of the study was evaluated on the basis of type of procedure, days of hospital stay, postoperative complications like seroma and pus discharge. Results: Out of two hundred patients included in this study, 100 patients underwent minor procedure and the other 100 underwent major procedure. Age distribution for minor cases less than 25 is 3, 26-50 is 42 and 51-75 is 103 with mean ± SD is 50.41± 14.25 and for major cases less than 25 is 1, 26-50 is 51, 51-75 is 48 with mean ± SD is 50.87± 13.59. Sex distribution of minor cases male 48 & female -52, major cases with distribution of male -45 and female -55. Hospitalisation of all minor cases are less than 1 day with mean value of 1 and major cases less than 1 day are 4, 2-3 days are 86 and more than 3 days are 10 with mean value of 2.3. Each patient was carefully monitored for the period of 30 days from the day of surgery and the complications, if any was treated accordingly. Out of 100 minor cases, seroma formation was noted in 3 patients and pus discharge in 4 patients. Collections were evacuated thorough wound wash and saline dressing were done (no antibiotics were given for these cases both preoperative as well as postoperative period). Whereas, Out of 100 major cases (single dose of preoperative antibiotics are given) seroma formation were noted in 7 patients, seroma collections were evacuated, thorough wound wash and saline dressing were done (no antibiotics were given for these cases), Pus discharge was found in 7 patients, among them 4 were treated with I V Antibiotics for 5 days according to pus culture and sensitivity report. Conclusion: The 200 patients who underwent procedure with single application of alcohol based antiseptic solution (2% chlorhexidine) for pre-operative preparation, was found to be effective against surgical site infections.
Theoretical calculation of reduction potentials

The.reduction. potential.is. a.direct. measure.of. the.thermodynamic. feasibility.of. an.oxidation–. reduction.half. reaction;. and. it. is. fundamentally. important. in.many. aspects.of. organic,. bioinorganic,. and.environmental. chemistry,. as.well. as.in. biology.and. materials.science. The.design. of.rational. strategies.for. tuning.the. redox.properties. of.compounds. depends.on. understanding. the.key. molecular.features. that.dictate. the.reduction. potential.As. an.example,. in.environmental. chemistry,. chlorinated.aliphatic. compounds.are. common.environmental. contaminants.due. to. their.widespread. use.as. solvents. and.degreasers. and.are. known. to.degrade. via.a. reductive.
ADVANCES IN FUNCTIONALIZATION OF POLYMER SUPPORTS FOR SYNTHESIS AND MODIFICATION OF OLIGONUCLEOTIDES

With the advent of commercial applications in biotechnology the economic importance of oligonucleotides including linkers, adaptors, primers etc. and the starting materials for their synthesis such as the nucleosides, the nucleotides and the basic reagents and chemicals required for their modifications has enhanced enormously. In monetary terms, they contribute in our estimate to nearly the equivalent of US$ 0.2 billion in global business. The main users of the whole range are the U.S., Europe, Japan, Canada and Australia, but the consumption in the developing countries especially in Asia, South American countries and Cuba is increasing fast.
Magnetic Mesoporous Nanocarriers for Drug Delivery with Improved Therapeutic Efficacy

Mesoporous CoNi@Au core@shell nanorods are synthesized as magnetic drug nanocarriers by electrodeposition using ionic liquid‐in‐aqueous microemulsions. Mesoporous nanorods present a highly effective area (186 m2 g−1) and magnetic character that allows their manipulation, concentration, and retention by applying a magnetic field. The nanorods have been functionalized with thiol‐poly(ethyleneglycol) molecules, and molecules of Irinotecan, a drug used in chemotherapy, are retained in both the lattice of the linked thiol‐poly(ethyleneglycol) molecules and inside the interconnected nanorods pores. The nanorods' mesoporous character allows a high drug‐loading capability and magnetic behavior that allows the drug's controlled release. A high cellular viability of HeLa cells is obtained after their incubation with the nanorods functionalized with thiol‐poly(ethyleneglycol). However, when the nanorods function as carriers for Irinotecan, significant cell death is occurred when HeLa cells are incubated with the functionalized, drug‐loaded nanorods. Cell death is also produced by applying an alternating magnetic field due to both the effect of the release of Irinotecan from the carrier as to mechanical damage of cells by nanorods subjected to the effect of a magnetic field. The proposal to used mesoporous magnetic nanorods as drug carriers can thus dramatically reduce the amounts of both nanocarrier and drug needed to efficiently destroy cancer cells.
The Other Side of the Story

This article provides a critique of the role played by progressive missionaries in securing land for the African people in some selected mission stations in South Africa. It argues that, in spite of the dominant narrative that the missionaries played a role in the dispossession of the African people of their land, there are those who refused to participate in the dispossession. Instead, they used their status, colour and privilege to subvert the policy of land dispossession. It critically examines the work done by four progressive missionaries from different denominations in their attempt to subvert the laws of land dispossession by facilitating land ownership for Africans. The article interacts with the work of Revs John Philip (LMS), James Allison (Methodist), William Wilcox and John Langalibalele Dube (American Zulu Mission [AZM]), who devised land redistributive mechanisms as part of their mission strategies to benefit the disenfranchised Africans.
Integrated Multi-Omics Data Analysis Reveals Altered Metabolome Activity and Microbiome Composition in Irritable Bowel Syndrome

Background: Irritable bowel syndrome (IBS) is one of functional gastrointestinal disorders mainly characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and the exact mechanism is still debatable. IBS-specific microbiota and metabolite remain poorly understand. To address this issue, we performed untargeted metabolomic and shotgun metagenomic profiling of stool and serum samples from discovery (n=330) and validation (n=101) cohorts of IBS and healthy individuals. Results: Fecal “omics” data show moderate dysbiosis compared with other disease, in contrast, serum metabolites show significant differences and have great power to discriminate IBS from healthy subjects. Specifically, 726 differentially abundant serum metabolites are identified, including fatty acyl-CoA enriched in IBS. Integrating microbiome and metabolome data, we identified 522 robust associations between differentially abundant species and fecal metabolites, of which three species are strongly associated with the low abundance of dihydropteroic acid. Moreover, the tryptophan enrichment correlates with the severity of IBS depression in both fecal and serum metabolomes. Conclusions: Collectively, our study unveils serum/fecal metabolome alterations and their relationship with gut microbiome and highlight the massive dysbiosis of serum metabolites which empower to discriminate IBS patients. Our study also provides a valuable resource for future studies to understand host-gut microbiota relationships, and facilitate potential clinical applications using microbiota and (or) metabolites to evaluate IBS patients with depression.
A Study of Lime Beer Formulations

The suitable method to produce low-hopped ale with a lime flavor formulation and the optimum formulation for lime juice beer production was studied in this experimental work. The experiment was divided into three stages. In stage 1, the lime juice concentrations of 0.3, 0.6, 1, 2, and 3% (v/v) were added before and after the primary fermentation, respectively, to determine the optimum lime juice content and time of lime juice addition. In stage 2, hop additions were set to 0.12, 0.14, 0.1% 0.18 and 0.20% to determine the optimum hop addition. In stage 3, the wort boiling temperatures were set to 85-90, 90-95 and 95-100°C to determine the optimum wort boiling temperature. The alcohol content, pH, sugar content, specific gravity, color, total acidity and vitamin C content were tested for each sample and sensory evaluation was held to determine the optimum fermentation factors. Our results showed that the best lime beer in this study was produced by adding 0.3% (v/v) lime juice after primary fermentation. The optimum hop addition was 0.18% w/v and the wort boiling temperature was 95-100°C. The final product of lime juice beer had a bright pale color, with a color of 12 EBC, and it had a pleasant aroma and taste.
Single-Walled Carbon Nanotube–Metalloporphyrin Chemiresistive Gas Sensor Arrays for Volatile Organic Compounds

: A chemiresistive sensor array was created from single-walled carbon nanotubes (SWCNTs) by non-covalent modification with late first-row transition metal complexes of meso -tetraphenylporphyrin. The responses to vapors of various volatile organic compounds (VOCs) were strong and were subjected to statistical analyses that enabled the successful classification of representative VOCs into five different categories (aliphatic hydrocarbons, alcohols, ketones, aromatic hydrocarbons, and amines) with 98% accuracy. With the exception of amines, which are capable of strong charge transfer interactions, the basis of classification appears to correlate with the differences in the solubility properties of the porphyrin compounds in the various VOCs as solvents. This feature suggests that an analyte with greater intermolecular affinity for the SWCNT-porphyrin composite will induce a greater response. These results further demonstrate the potential for porphyrin-functionalized SWCNT-based electronic noses for applications in inexpensive, portable chemical sensors for the identification of VOCs. Content summary: A chemiresistive sensor array was created from single-walled carbon nanotubes (SWCNTs) by noncovalent modification with transition metal complexes of meso -tetraphenylporphyrin. Statistical analyses of the responses to various volatile organic compounds (VOCs) enabled their successful classification into five different categories (ali-phatic hydrocarbons, alcohols, ketones, aromatic hydrocarbons, and amines) with 98% accuracy.
Education au développement durable par la pédagogie de projet : Cas de l'Ecole Nationale Supérieure d'Electricité et de Mécanique – Maroc

Les multiples reformes du systeme educatif visent l’integration de l’education en vue d’un developpement durable (EDD). Le present article presente une etude de cas illustrant les demarches deployees par les enseignants de la filiere Genie industriel et logistique de l'Ecole Nationale Superieure d'Electricite et de Mecanique (ENSEM) en matiere d’education au developpement durable basee sur la pedagogie par projet en presentant deux projets : le premier projet est a caractere social tandis que le deuxieme est a caractere environnemental.
Thermochromic AIE Dual Phosphorescence via Temperature-Dependent sp3-Linked Donor-Acceptor Electronic Coupling

Aggregation-induced emission (AIE) has proven to be a viable strategy to achieve highly efficient RTP in bulk by restricting molecular motions. Here we show that by utilizing triphenylamine (TPA) as an electronic donor which connects to an acceptor via an sp3 linker, six TPA-based AIE-active RTP luminophores were obtained. Both the TPA AIE-gen and the sp3-linkage can suppress aggregation-caused quenching. Consequently, dual phosphorescence bands emitting from localized donor and acceptor triplet states, respectively, could be recorded at lowered temperatures; at room temperature, only a single RTP band corresponding to the lowest triplet state is present, presumably due to thermally assisted electronic coupling between the two states. The reported molecular construct serves as an “intermediary case” between a fully conjugated donor-acceptor system and a do-nor/acceptor binary mix, which may provide important clues on the design and control of molecular systems with complex excited-state dynamics.
Effects of Dietary Nucleotide Supplementation on Growth Performance, Internal Organs, Blood Metabolites, and HIF-1α mRNA Expression in Ascites Induced Broiler Chickens

This experiment was conducted to study the effects of nucleotide supplementation on induced ascites and its effects on growth performance, blood metabolites, and expression of hypoxia-inducible factor 1α (HIF-1α) mRNA in Ross 308 broiler chickens. A total of 672 one-day-old Ross 308 broiler chicks were allocated to eight treatments with two levels of common salt in drinking water (0 and 2 g/lit) and four dietary supplemental levels of nucleotides (0, 0.5, 1, and 2 g/kg diet). Each treatment was included 7 replicates of 12 birds each. The experimental design was completely randomized in a factorial arrangement. In this study, 0.2% salt in drinking water induced ascites, decreased body weight (BW), and increased mortality, right ventricle (RV) weight as well as RV to total ventricles ratio (P < 0.05). Results showed that nucleotide levels of 0.05 and 0.1% significantly decreased RV weight and blood triiodothyronine (T3) concentration on 42 d. Interaction effects between salt and nucleotide supplement revealed that 0.1% nucleotide level in the salt group significantly reduced blood T3 concentration in comparison with non-nucleotide supplemented and normal water group. Feed intake, weight gain, feed conversion ratio, carcass characteristics, and the expression of HIF-1α mRNA in heart of broilers were not significantly affected by excess salt, nucleotide supplement, and their interaction. It was concluded that 0.5 g/kg dietary nucleotide supplementation decreased the ascites parameter of the RV/BW ratio in broiler chickens.
Evaluation of Phytochemical & Antimitotic Potential of Annona Reticulata Extracts by Onion Root Model

This study investigated photochemical investigation and extraction methods with polar and non-polar solvent which could be used to compare and see the effectiveness of each on the chromosomes. The FTIR spectrum shows the presence of acetogenins in the extracts. Cytotoxic effects were studied using Allium cepa root tip cells. Eight onion bulbs were subjected to the treatment groups which were made using water, methanol, Ethyl acetate, acetone and hexane extracts of A. reticulata. Three different concentrations from each extraction solvent were used. The A. cepa root tip cells were subjected for 24 h to three different leaf extractions after left to grow in water. Concentrations of 0.1, 1, 10 and 50 mg/L were used. All studied concentrations of A. reticulata methanol extract showed significant (p < 0.05) drop in the mean mitotic index when compared with control Overall decrease in MI was contributed to by all the stages of mitosis.
Synthesis of Functionalized Thiopyrano [2,3-b]quinolines via Cascade Reactions Catalyzed by Magnetic Arginine/Alginate Biocomposite

An effective synthesis of functionalized thiopyrano [2,3-b]quinolines has been described via cascade reactions using super paramagnetic iron oxide nanoparticles (SPIONs) coated with L-arginine (Arg) grafted alginate (Alg), called Fe3O4@Alg@CPTMS@Arg. The reaction was performed between commercially available CH acid compounds such as dimedone or malononitrile, and 2-mercapto-quinoline-3-carbaldehydes under green conditions. This efficient method provides a new route for the formation of functionalized three or four fused rings.