Miracle-dz/UniFAR-FTUs huggingface dataset:
Randomized trial of a depression management program in high utilizers of medical care.

BACKGROUND High utilizers of nonpsychiatric health care services have disproportionally high rates of undiagnosed or undertreated depression. OBJECTIVE To determine the impact of offering a systematic primary care-based depression treatment program to depressed "high utilizers" not in active treatment. DESIGN Randomized clinical trial. SETTING One hundred sixty-three primary care practices in 3 health maintenance organizations located in different geographic regions of the United States. PATIENTS A group of 1465 health maintenance organization members were identified as depressed high utilizers using a 2-stage telephone screening process. Eligibility criteria were met by 410 patients and 407 agreed to enroll: 218 in the depression management program (DMP) practices and 189 in the usual care (UC) group. INTERVENTION The DMP included patient education materials, physician education programs, telephone-based treatment coordination, and antidepressant pharmacotherapy initiated and managed by patients' primary care physicians. MAIN OUTCOME MEASURES Depression severity was measured using the Hamilton Depression Rating Scale (Ham-D) and functional status using the Medical Outcomes Study 20-item short form (SF-20) subscales. Outpatient visit and hospitalization rates were measured using the health plan's encounter data. RESULTS Based on an intent-to-treat analysis, at least 3 antidepressant prescriptions were filled in the first 6 months by 151 (69.3%) of 218 of DMP patients vs 35 (18.5%) of 189 in UC (P < .001). Improvements in Ham-D scores were significantly greater in the intervention group at 6 weeks (P = .04), 3 months (P = .02), 6 months (P < .001), and 12 months (P < .001). At 12 months, DMP intervention patients were more improved than UC patients on the mental health, social functioning, and general health perceptions scales of the SF-20 (P < .05 for all). CONCLUSION In depressed high utilizers not already in active treatment, a systematic primary care-based treatment program can substantially increase adequate antidepressant treatment, decrease depression severity, and improve general health status compared with usual care.
Coexistence of Two Distinct Copies of Naphthalene Degradation Genes in Pseudomonas Strains Isolated from the Western Mediterranean Region

ABSTRACT We analyzed the occurrence of the naphthalene degradation upper-pathway (nah) genes in the western Mediterranean region. The amplification, restriction, and sequence analysis of internal fragments for several nah genes (nahAc, nahB, nahC, and nahE) from naphthalene-degrading strains isolated from this geographical area proved the coexistence of two distinct sets of nah genes.
Factors which Improve the Construct Validity of Assessment Centers: A Review

This article reviews 21 studies which manipulated specific variables to determine their impact on the construct validity of assessment centers. This review shows that the studies regarding the impact of different observation, evaluation, and integration procedures yielded mixed results. Conversely, dimension factors (number, conceptual distinctiveness, and transparency), assessor factors (type of assessor and type of assessor training), and exercise factors (exercise form and use of role-players) were found to moderate construct validity. On the basis of the review, practical recommendations are derived to maximize the probability that practitioners design and administer an assessment center with construct validity. Finally, new perspectives for future research are identified.
SDG 2-Mediated H 3 K 4 me 3 Is Crucial for Chromatin Condensation and Mitotic Division during Male Gametogenesis in Arabidopsis 1 [ OPEN ]

Université de Strasbourg, Centre National de la Recherche Scientifique UPR2357, F-67000 Strasbourg, France (V.P., W.-H.S.); State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of Centre National de la Recherche Scientifique-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (X.Y., A.D., W.-H.S.); and College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, China (X.Y.)
Composition of Air Pollution Particles and Oxidative Stress in Cells, Tissues, and Living Systems

Epidemiological studies demonstrated an association between increased levels of ambient air pollution particles and human morbidity and mortality. Production of oxidants, either directly by the air pollution particles or by the host response to the particles, appears to be fundamental in the biological effects seen after exposure to particulate matter (PM). However, the precise components and mechanisms responsible for oxidative stress following PM exposure are yet to be defined. Direct oxidant generation by air pollution particles is attributed to organic and metal components. Organic compounds generate an oxidative stress through redox cycling of quinone-based radicals, by complexing of metal resulting in electron transport, and by depletion of antioxidants by reactions between quinones and thiol-containing compounds. Metals directly support electron transport to generate oxidants and also diminish levels of antioxidants. In addition to direct generation of oxidants by organic and metal components, cellular responses contribute to oxidative stress after PM exposure. Reactive oxygen species (ROS) production occurs in the mitochondria, cell membranes, phagosomes, and the endoplasmic reticulum. Oxidative stress following PM exposure initiates a series of cellular reactions that includes activation of kinase cascades and transcription factors and release of inflammatory mediators, which ultimately lead to cell injury or apoptosis. Consequently, oxidative stress in cells and tissues is a central mechanism by which PM exposure leads to injury, disease, and mortality.
English Verbal Morphology and VP Ellipsis

1his paper investigates the influences of verbal morphology on the (im)possibility of VP ellipsis (VPE) in English. VPE is a well-known process in which a VP constituent is missing under some kind of identity with another VP in the discourse. (1) illustrates. There is an overt VP, the antecedent, which substitutes interpretationally for an inaudible VP elsewhere, the target. Typically below, the antecedent will be bracketed and the elided VP will be explicitly indicated by striking through the unpronounced material. For concreteness, I take VPE to be deletion of a VP at PF (Hankamer and Sag 1976, Sag 1980, Chomsky 1995, and others), although nothing hinges on this assumption since parallel issues arise in a theory ofVPE as LF copying (Wasow 1972, Williams 1977, Chao 1988).
Adaptive Updating Probabilistic Model for Visual Tracking

SUMMARY In this paper, an adaptive updating probabilistic model is proposed to track an object in real-world environment that includes motion blur, illumination changes, pose variations, and occlusions. This model adaptively updates tracker with the searching and updating process. The searching process focuses on how to learn appropriate tracker and updating process aims to correct it as a robust and e ﬃ cient tracker in unconstrained real-world environments. Speciﬁcally, according to various changes in an object’s appearance and recent probability matrix (TPM), tracker probability is achieved in Expectation-Maximization (EM) manner. When the tracking in each frame is completed, the estimated object’s state is obtained and then fed into update current TPM and tracker probability via running EM in a similar manner. The highest tracker probability denotes the object location in every frame. The experimental result demonstrates that our method tracks targets accurately and robustly in the real-world tracking environments. key words: visual tracking, transition probability matrix, expectation-maximization
Asbestos-like fibers in Duluth water supply. Relation to cancer mortality.

Asbestos-like fibers in industrial waste first entered the water supply of Duluth in 1955. In the next 14 years, no carcinogenic effect was apparent in the patterns of cancer mortality among persons of all ages, nor among children. The period of observation is short relative to the latent period for occupationally induced carcinogenesis from asbestos. ( JAMA 228:1019-1020, 1974)
Tissue Doppler, a fundamental tool for parametric imaging

Tissue Doppler has been used for clinical applications since 1989. It has been developed from a pulsed Doppler acquisition tool towards a method where extraction of velocities can be performed from colour‐coded images. This has introduced a further development into different forms of parametric images describing different myocardial functions as colour‐coded information, like deformation imaging, motion imaging and phase imaging. The technical requirements have been established with temporal requirements of frame rates in acquisition exceeding 100 frames s−1. The most powerful application of the tissue Doppler technique today is perhaps to quantify the myocardial functional reserve, during stress echocardiography, making the method applicable to diagnose the presence of coronary disease with an accuracy exceeding that of nuclear and other non‐invasive techniques. The method has also great potential for future developments with introduction of more regional measuring variables.
Antigenic Phenotype and Phagocytic Capacity of MG‐63 Osteosarcoma Line

Human osteoblasts isolated from bone tissue samples have their own specific antigen profile but also share expression of antigens that are characteristic of other immunocompetent cells. Given that these findings come from studies performed in primary cultures of human osteoblasts, it was decided to test whether these antigen profiles and functional characteristics are retained in a characterized osteoblast cell line (MG‐63). We show that some of these characteristics are also found in the MG‐63 osteosarcoma cell line. We have demonstrated, using monoclonal antibodies and cytometry, that these cells expressed CD10, CD13, CD44, and CD54 antigens but were negative for CD69 and HLA‐DR antigens. Functionally, 100% of MG‐63 cells showed phagocytic capacity with a high phagocytic index. This study corroborates that osteoblastic cells have an immunological profile.
Loss analysis & design of charge-pumped voltage supply for floating gate driver circuits in battery management system

The long turn-on time of floating power switches in BMS (battery management system) employ charge pump circuits generally. It is powered from the batteries so that power losses analysis is very important, but not easy. In this paper, a charge pump circuit will be introduced, which can be easily employed for BMSs as well as its operating principle will be explain in detail with calculation of the power consumption based on Charge Conservation Law. Finally, the analysis will be verified by a simulation.
Oxytocin release following osmotic activation of oxytocin neurones in the paraventricular and supraoptic nuclei

1. Recordings were made from a total of 35 antidromically identified neurones in the paraventricular (PV) and supraoptic (SO) nuclei of urethane‐anaesthetized lactating rats. During recording plasma osmotic pressure was raised by 12 m‐osmole/kg by injection of hypertonic solutions of NaCl, LiCl, or mannitol.
artVIS: an interactive visualization for painting collections

Painting galleries typically provide a wealth of data composed of several data types. Those multivariate data are too complex for laymen like museum visitors to first, get an overview about all paintings and to look for specific categories. Finally, the goal is to guide the visitor to a specific painting that he wishes to have a more closer look on. In this paper we describe an interactive visualization tool that first provides such an overview and lets people experiment with the more than 41,000 paintings collected in the web gallery of art. To generate such an interactive tool, our technique is composed of different steps like data handling, algorithmic transformations, visualizations, interactions, and the human user working with the tool with the goal to detect insights in the provided data. We illustrate the usefulness of the visualization tool by applying it to such characteristic data and show how one can get from an overview about all paintings to specific paintings.
[Blood pressure assessed through oscillometric and auscultatory method before and after exercise in the elderly].

BACKGROUND Different methods of measuring blood pressure (BP) have been used in clinical and scientific evaluations. However, the methods employed have constraints and peculiarities to be considered. OBJECTIVE To evaluate whether similar BP values are obtained in elderly hypertensive patients undergoing resistance exercises when using the oscillometric (Omron-HEM-431) and auscultatory methods (mercury sphygmomanometer). METHODS Sixteen elderly hypertensive patients underwent three randomized experimental sessions with different volumes: control (C: 40 minutes), exercise 1 (E1: 20 minutes) and exercise 2 sessions (E2: 40 minutes). BP was measured simultaneously through two methods every 5 minutes for 20 minutes before the sessions and during 60 minutes after them. RESULTS In the pre-intervention period, there was concordance between systolic blood pressure (SBP) and diastolic blood pressure measurements (DBP) obtained through two methods, as well as a high overall concordance after the sessions (Lin's concordance coefficient = 0.82 and 0.81, respectively). Greater concordance in DBP was found after the control session than after exercise sessions. The difference between the measurements obtained between the two methods was greater for DBP than for SBP after all sessions (p < 0.001). Regardless of the method, SBP and DBP fell in the first 60 minutes after the exercises. CONCLUSION The auscultatory and oscillometric methods were consistent before and after the control and exercise sessions. However, greater differences were found in DBP than in SBP. The latter was very similar between methods.
Air Quality Impacts of Petroleum Refining and Petrochemical Industries

Though refineries and petrochemical industries meet society’s energy demands and produce a range of useful chemicals, they can also affect air quality. The World Health Organization (WHO) has identified polluted air as the single largest environmental risk, and hence it is necessary to strive for and maintain good air quality. To manage potential health impacts, it is important to implement proper air quality management by understanding the link between specific pollutant sources and resulting population exposures. These industries release pollutants such as Volatile Organic Compounds, greenhouse gases and particulate matter, from various parts of their operations. Air quality should be monitored and controlled more meticulously in developing nations where increased energy demands, industrialization and overpopulation has led to more emissions and lower air quality. This paper presents a review of findings and highlights from various studies on air quality impacts of petroleum refining and petrochemical plants in many regions in the world.
DISFLUENCY DETECTION ACROSS DOMAINS

This paper focuses on disfluency detection across distinct domains using a large set of openSMILE features, derived from the Interspeech 2013 Paralinguistic challenge. Amongst different machine learning methods being applied, SVMs achieved the best performance. Feature selection experiments revealed that the dimensionality of the larger set of features can be further reduced at the cost of a small degradation. Different models trained with one corpus were tested on the other corpus, revealing that models can be quite robust across corpora for this task, despite their distinct nature. We have conducted additional experiments aiming at disfluency prediction in the context of IVR systems, and results reveal that there is no substantial degradation on the performance, encouraging the use of the models in IVR domains.
Why are community psychiatric services in Australia doing it so hard?

If there is one constant in medicine, it is change. Medical education has not escaped this phenomenon, with recent initiatives including early exposure to real-world clinical experiences, a shift from pedagogical teaching to self-learning, and an emphasis on problembased learning and effective communication. The ultimate aim is to produce an individual who is grounded in patient care and medical knowledge, committed to lifelong learning, and an exemplar of communication. Feeding this stream of graduates is an array of undergraduate and graduate medical schools with a variety of curricula.
The Frequency of Cardiac Arrhythmias in Children with Congenital Heart Disease during Angiography

Although new various non-invasive procedures such as echocardiography and imaging, in congenital heart disease diagnosis have a special place, but as a practical method at inefficiency of these modalities, cardiac angiography said to us the hidden aspects of the cardiac diseases.The field of cardiac catheterization has evolved, performing more interventional compared with diagnostic cases. In the meantime, the nature of interventional cardiology has changed, with a greater percentage of patients undergoing catheter-based intervention [1].
Issues and unmet needs in pediatric asthma

Asthma is common and becoming more so in childhood. Although mild asthma may incur low average annual costs per child, these estimates need to be viewed in the context of the very large numbers of affected individuals. Whereas asthma and wheezing illness in childhood had in the past been broadly subdivided into asthma (often associated with atopy) and wheezy bronchitis (wheeze only, with associated upper respiratory tract infection), this distinction was lost during the 1970s in view of the demonstrated underdiagnosis and undertreatment of symptomatic school‐age children. The acceptance of asthma as a chronic inflammatory disease and evidence for airway remodeling and progressive deterioration in airway function in association with symptoms and atopy have led to earlier use of topical steroids at higher starting doses delivered by improved age‐appropriate devices. Treating all children as if they were destined to become atopic asthmatics and at risk of airway remodeling may not be rational, particularly in those whose symptoms will subsequently resolve. However, there are as yet no screening tests which can clearly identify individuals at risk of long‐term chronic airway inflammation and airway remodeling. The large number of infants and young children with current symptoms suggestive of asthma and in whom resolution is likely in the majority poses problems for the clinician in deciding the best initial therapy. There is an urgent need to develop simple and reliable measures that can identify the early manifestations of atopic airway sensitisation and to establish the place of early intervention with nonsteroidal drugs, including leukotriene antigonists. Pediatr Pulmonol. 2000; 30:159–165. © 2000 Wiley‐Liss, Inc.
Low-dose aspirin and upper gastrointestinal damage:epidemiology, prevention and treatment

ABSTRACT Background: Low-dose aspirin (75–325 mg/day) is widely used for the prevention of cardiovascular disease. However, due to its action on cyclo-oxygenase (COX), aspirin is associated with upper gastrointestinal (GI) side effects including ulcers and bleeding. Scope: This was a comprehensive review of the literature available on the side effects associated with low-dose aspirin, together with the available treatment and prevention options, which was based on the authors’ expertise in the field and a supplementary PubMed search limited to papers published in English during the last 10 years, up to November 2006. Findings: Although the risk of upper GI side effects is smaller with low-dose aspirin compared with non-selective, non-steroidal anti-inflammatory drugs (NSAIDs), it is nevertheless a substantial healthcare issue. Factors associated with an increased risk of upper GI complications during low-dose aspirin therapy include aspirin dose, history of ulcer or upper GI bleeding, age > 70 years, concomitant use of NSAIDs (including COX‑2-selective NSAIDs), and Helicobacter pylori infection. Co-administration of a gastroprotective agent such as proton pump inhibitors (PPIs) may be useful for alleviating the upper GI side effects associated with use of low-dose aspirin. Eradication of H. pylori also appears to reduce the risk of these side effects, especially in those at high risk. The use of other antiplatelet agents such as clopidogrel does not seem to provide a safer alternative to low-dose aspirin in at-risk patients. Conclusions: Prophylactic low-dose aspirin therapy is associated with an increased risk of developing upper GI side effects. Administration of a PPI seems the most effective therapy for the prevention and/or relief of such side effects in at-risk patients. H. pylori eradication therapy further reduces the risk of upper GI bleeding in these patients.
Drift analysis

Drift analysis, introduced to the field of evolutionary computation by He and Yao ten years ago, quickly became one of the strongest tools to prove upper and lower bounds on the run-times of evolutionary algorithms. It has, however, the reputation of being difficult to use, both because it relies on deeper mathematical tools and because it needs a clever guess of a potential function. In this tutorial, after presenting the classical results, I will focus on the recently developed multiplicative drift analysis method. It often is easier to employ and yields stronger results, e.g., run-time bounds that hold with high probability. I will end with a number of open problems of different difficulties. The intended audience of the tutorial has some basic experience in theory, though no particular prerequisites are required.
Saccadic eye movement strategies in patients with homonymous hemianopia

Infrared oculographic recordings from three patients with hemianopia due to an occipital lesion showed that these patients employed a consistent set of (presumably unconscious) compensatory strategies to find and fixate objects. For targets in the blind hemifield, patients at first used a staircase strategy consisting of a series of stepwise saccadic search movements. This is safe but slow. When retested later, one patient had adopted a more efficient strategy employing one large saccadc calculated to overshoot the target. Other strategies for finding targets in the blind hemifield were employed in response to specific situations presented by our experiments: a predictive strategy using past experience to anticipate where the target would be found, and special strategies for recovering a lost target and for awaiting the reappearance of the target. To fixate targets in the seeing hemifield, our subjects undershot the target to prevent losing it in the blind hemifield, then held it off‐fovea on the seeing side of the macula.