Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic testing for Best vitelliform macular dystrophy

Abstract We studied the scientific literature and disease guidelines in order to summarize the clinical utility of the genetic test for Best vitelliform macular dystrophy (BVMD). BVMD is mostly inherited in an autosomal dominant manner (autosomal recessive transmission is rare). The overall prevalence is currently unknown. BVMD is caused by mutations in the BEST1 gene. Clinical diagnosis is based on clinical findings, ophthalmological examination, optical coherence tomography, electrooculography and electroretinography. The genetic test is useful for confirming diagnosis, and for differential diagnosis, couple risk assessment and access to clinical trials.
EVALUATION OF SELECTED RISK TYPES IN EXTERNAL TRANSPORT WITH THE USE OF THE MATRIX METHOD

Risk is a common phenomenon in daily life of natural and legal persons. It concerns all branches of the economy and relates to making decisions concerning the unknown future. There are various types of risk related to business operations and the majority of business entities take effort to protect themselves from its adverse effects. The development of the field of risk management allows for partial or total risk elimination. Road transport is exposed to various types of risk which may lead to usually considerable damage and losses. This publication is aimed at presenting selected groups of risk factors occurring in the logistics process and at determining their influence on enterprise functioning. It is also supposed to emphasise the significant role of risk analysis in the transportation business.
A Technology Agnostic Approach for Standard-cell Layout Design Automation

The logic scaling following Moores law has reached a level where System on Chips (SoCs) commonly contains millions of standard cells. The sheer amount implies that even small optimizations on a standard cell can have a significant effect on the SoC performance. To ensure the performance of standard cells, many of these are hand-drawn. This is a tedious task that needs to be done every time a new process technology emerges. Something which requires both many man-hours and that holds a risk of designing sub-optimal solutions or introducing human error into the design. Presented in this thesis is a method for automatizing the complete design process of standard cell layouts, requiring only a netlist and a few fundamental design rules for the given technology. The overall procedure was divided into three parts: placement, routing, and evaluation. The tool is entirely built in Python and for functionality verification commercial EDA tools from CadenceTM were used. The generated standard cells have shown to match the area requirements of typical industry-level standard cells and in some critical complex cells even outperform them.
Kendali Robot Beroda Dengan Gerak Isyarat Tangan Berbasis Image Processing

Abstrak Computer vision didasarkan pada pengenalan bentuk yang memiliki banyak potensi dalam interaksi manusia dan komputer. Isyarat tangan dapat dijadikan simbol interaksi manusia dengan komputer seperti halnya pada penggunaan berbagai isyarat tangan pada bahasa isyarat. Berbagai isyarat tangan dapat digunakan untuk menggantikan fungsi remote control, untuk mengendalikan robot, dan sebagainya. Proses mengolah gambar atau citra tangan dengan menggunakan computer vision ini dinamakan image processing. Pada tugas akhir ini dibuat sistem kendali robot beroda yang dapat bergerak sesuai dengan perintah isyarat tangan yang diberikan. Ada 6 bentuk isyarat tangan yang dijadikan sebagai input, dan setiap isyarat tangan memberikan satu perintah pergerakan robot beroda. Metode yang digunakan untuk melakukan klasifikasi tiap isyarat, yaitu Convolutional Neural Network (CNN). CNN adalah salah satu cabang dari Jaringan Syaraf Tiruan (JST) yang dapat melakukan ektraksi fitur dan membuat kategori yang diinginkan. Hasil klasifikasi akan diproses dan dikirimkan secara wireless ke dalam robot untuk menjalankan suatu pergerakan. Hasil dari sistem ini yaitu pergerakkan robot beroda sesuai dengan isyarat tangan yang diberikan.Variabel yang mempengaruhi sistem ini adalah parameter pelatihan atau training data dan parameter lingkungan yang meliputi besar intensitas cahaya, jarak, dan sudut kemiringan. Adapun tingkat akurasi seluruh sistem yang diperoleh adalah 91,33%. Kata Kunci : digital image processing, robot, Convolutional Neural Network Abstract Computer vision based on shape recognition has a lot of potential in human and computer interaction. Hand gestures can be used as symbols of human interaction with computers which are preferred in the use of various hand gestures in sign language. Various tasks can be used to set remote control functions, to control robots, and so on. The process of processing images or hand drawings using computer vision is called image processing. In this final project, a wheeled robot control system can be moved according to the given hand gesture commands. There are 6 forms of hand gestures that are made as input, and each hand gesture gives one command for the movement of a wheeled robot. The method used to classify each gesture, namely Convolutional Neural Network (CNN). CNN is a branch of the Artificial Neural Network (ANN) that can perform extraction features and create desired classification. The results of the classification will be carried out and sent to a wireless robot to run a movement. The result of this system is the movement of the wheeled robot in accordance with the given hand gestures. Variables that affect this system are training parameters and environmental parameters which include the amount of light intensity, distance, and tilt angle. The accuracy of the entire system obtained is 91,33%. Keywords : digital image processing, robot, Convolutional Neural Network
Predictive Maintenance in Industry 4.0

In the context of Industry 4.0, the manufacturing related processes have shifted from conventional processes within one organization to collaborative processes cross different organizations, for example, product design processes, manufacturing processes, and maintenance processes across different factories and enterprises. The application of Internet of things, i.e. smart devices and sensors increases collection and availability of diverse data. Advanced technologies such as big data analytics and cloud computing offer new opportunities for effective optimization of manufacturing related processes, e.g. predictive maintenance. Predictive maintenance provides a detailed examination of the detection, location and diagnosis of faults in related machineries using various analyses. RAMI4.0 is a framework for thinking about the various efforts that constitute Industry 4.0. It spans the entire product life cycle & value stream axis, hierarchical structure axis and functional classification axis. The Industrial Data Space (now International Data Space) is a virtual data space using standards and common governance models to facilitate the secure exchange and easy linkage of data in business ecosystems. It thereby provides a basis for creating and using smart services and innovative business processes, while at the same time ensuring digital sovereignty of data owners. This paper looks at how to support predictive maintenance in the context of Industry 4.0? Especially, applying RAMI 4.0 architecture supports the predictive maintenance using FIWARE framework, which leads to deal with data exchanging among different organizations with different security requirements as well as modularizing of related functions.
Improving Retention in Care and Promoting Adherence to HIV Treatment: Protocol for a Multisite Randomized Controlled Trial of Mobile Phone Text Messaging

Background The World Health Organization has prioritized the use of new technologies to assist in health care delivery in resource-limited settings. Findings suggest that the use of SMS on mobile phones is an advantageous application in health care delivery, especially in communities with an increasing use of this device. Objective The main aim of this trial is to assess whether sending weekly motivational text messages (SMS) through mobile phones versus no text messaging will improve retention in care and promote adherence to treatment and health outcomes among patients receiving HIV treatment in Fako Division of Cameroon. Methods This is a multisite randomized controlled single-blinded trial. Computer-generated random block sizes shall be used to produce a randomization list. Participants shall be randomly allocated into the intervention and control groups determined by serially numbered sealed opaque envelopes. The 156 participants will either receive the mobile phone text message or usual standard of care. We hypothesize that sending weekly motivational SMS reminders will produce a change in behavior to enhance retention; treatment adherence; and, hence, health outcomes. Participants shall be evaluated and data collected at baseline and then at 2, 4, and 6 months after the launch of the intervention. Text messages shall be sent out, and the delivery will be recorded. Primary outcome measures are retention in care and adherence to treatment. Secondary outcomes are clinical (weight, body mass index), biological (virologic suppression, tuberculosis coinfection), quality of life, treatment discontinuation, and mortality. The analysis shall be by intention-to-treat. Analysis of covariates shall be performed to determine factors influencing outcomes. Results Recruitment and random allocation are complete; 160 participants were allocated into 3 groups (52 in the single SMS, 55 in the double SMS, and 53 in the control). Data collection and analysis are ongoing, and statistical results will be available by the end of August 2019. Conclusions The interventions will contribute to an improved understanding of which intervention types can be feasible in improving retention in care and promoting adherence to antiretroviral therapy. Trial Registration Pan African Clinical Trial Registry in South Africa PACTR201802003035922; https://pactr.samrc. ac.za/TrialDisplay.aspx? TrialID=3035 International Registered Report Identifier (IRRID) DERR1-10.2196/15680
Sonographic Echo-pattern of the Thyroid Gland among the Non-nodular Goitrous Patients Having Abnormal thyrotropin Level at their First Diagnosis

Method: This study was conducted at the Institute of Nuclear medicine and Allied Sciences, Rajshahi, Bangladesh during the period between 1st January, 2014 and 31st March, 2015. The goitrous patients are referred at this Institute by the clinicians for radionuclide thyroid scan, HRUS of thyroid gland and thyroid function tests. Under the basis of convenient sampling technique, 62 patients are included as sample. Their age, gender, HRUS echo-patterns of goiter and thyrotropin levels are recorded and analyzed with statistical software IBM SPSS v. 16.
Genomic Analysis of 727 Patients with Ehlers-Danlos Syndrome I: Clinical Perspective Relates 23 Genes to a Maternally Influenced Arthritis-Adrenaline Disorder

A novel medical approach for qualifying DNA variants found by whole exome sequencing (WES) facilitates discovery of new gene-disease relationships and emphasizes that DNA change must be correlated with clinical findings before having utility for diagnosis. Delineation of an arthritis-adrenaline disorder (AAD) process qualified variants in 23 genes as diagnostically useful in 727 patients having WES among 1656 with Ehlers-Danlos syndrome (EDS); these results distinguished them from 102 patients who had qualified gene variants among 728 with developmental disability. Excess maternal transmission of AAD by pedigree analysis plus 167 maternally versus 111 paternally transmitted DNA variants and 75 patients with only mitochondrial DNA variants suggest maternal influence on inheritance of AAD and its subsumed EDS types. Genes grouped by impact on different connective tissue elements showed variation in similar numbers of patients with hypermobile or classical EDS, benign joint hypermobility, or predominant dysautonomia: COL7A1, FLG acting on skin in 21 patients; SCN9A/10A/11A, POLG on nerve in 24; COL6A1/A2/A3, COL12 on muscle in 19; COL5A1/A2, FBN1, TGFB2/3, TGFBR1/2 on tissue matrix in 51; COL3A1, VWF on vessel in 18; COL1A1/A2, COL11A1/A2 acting on bone in 15 patients. Each gene group acts through a postulated articulo-autonomic dysplasia cycle to produce reciprocal tissue laxity and dysautonomia findings that transcend EDS types. This same tissue laxity-dysautonomia cycle acts to produce secondary complications in disorders ranging from distinctive connective tissue dysplasias to developmental disorders with hypotonia and acquired conditions with autonomic imbalance. Several altered genes were previously associated with neuromuscular disorders, foreshadowing a large myopathic EDS category that will incorporate many patients with hypermobility. The importance of muscle for joint constraint supports present exercise and future mesenchymal stem cell therapies, whether AAD is genetic or epigenetic from trauma, surgery, inflammation, or aging.
Barriers to achieving better drug adherence in patients with uncontrolled hypertension in primary care clinics

Background: Poor drug adherence is one of the leading causes of uncontrolled hypertension. Little is known about the barriers to attaining good drug adherence among Chinese patients in primary care setting. Methods: Cross-sectional questionnaire survey of patients with uncontrolled hypertension was performed in five primary care clinics in Hong Kong in 2016. Patients who attended regularly for hypertension follow-up, with office systolic blood pressure (SBP) > 140 mmHg &/or diastolic BP > 90 mmHg in recent 2 clinic visits were invited to participate. Structured questionnaire was designed to collect personal and clinical parameters. Drug adherence was assessed by the validated 8-item Morisky’s Medication Adherence Scale (MMAS-8). Health literacy was assessed by the Chinese Health Literacy Scale for Chronic Care (CHLSCC). Prescriptions, medical history and biochemical results were collected from electronic record system. Multi-variate logistic regression using low drug adherence as dependent variable was performed. Results: Two hundred and ninety one (291) participants were successfully interviewed. The male to female ratio was 0.65. The mean age was 67.0 (S.D. 9.9). More than 80% of them reported good to moderate drug adherence while 13.7% of them had low drug adherence. More than half of them had inadequate health literacy. The mean number of years since hypertension diagnosed was 9.65 (S.D. 8.73). Almost 40% of them had hypertension less than 5 years. The most popular prescription was once-daily regimen, with 2 or more type of anti-hypertensive drugs. Calcium channel blockers were most commonly prescribed. In the logistic regression model predicting low drug adherence, only diagnosis of HT less than 5 years was statistically significant (adjusted OR = 2.32, 95% C.I. 1.12-4.80, p = 0.02). There was no statistical significance in sex, older age, educational level, health literacy, occupation, number of types of antihypertensive drugs and daily frequency of drugs. Conclusion: In primary care setting, patients with uncontrolled hypertension reported satisfactory drug adherence. They would have lower drug adherence if their hypertension were diagnosed less than 5 years. *Correspondence to: FU Sau-nga, Department of Family Medicine and Primary Health Care, Ha Kwai Chung General Outpatient Clinic,77 Lai Cho Road, Kwai Chung, N.T. , Hong Kong, E-mail: h9317811@connect.hku. hk
Asociación entre la presencia de Helicobacter pylori y patología gástricas detectadas por endoscopia

Con el objetivo de determinar la relación que existe entre la presencia de Helicobacter pylori en biopsia con las patologías gástricas detectadas por endoscopias, se realizó la presente investigación. Para ello se recopilaron datos de 1468 pacientes que se sometieron a este procedimiento y a quienes se le realizó biopsia gástrica en busca de la bacteria. La recolección de datos se efectuó por consulta de los registros médicos de los pacientes evaluados por los gastroenterólogos que colaboraron con el presente estudio y se obtuvo información acerca de: edad, género, diagnóstico y presencia o ausencia de Helicobacter pylori en la biopsia realizada. Del total de 1468 pacientes, se encontró que 536 (36.5%) fueron hombres y 932 (63.5%) mujeres. Los resultados para Helicobacter pylori fueron positivos en 778 pacientes (53%) y negativos en 690 (47%). La patología gástrica que se observó con mayor frecuenica fue la gastritis crónica no atrófica en 415 pacientes (28.2%) seguida de la gastritis no especificada por el médico en 294 pacientes. El rango de edad en la que se presentó una mayor proporción de infección con Helicobacter pylori, fue de 41 a 50 años, no encontrando diferencia entre la presencia de Helicobacter pylori y el género. Se considera importante y necesario que en Guatemala se emplee una clasificación estándar para futuros estudios, como la clasificación de Sydney para determinar la presencia de Helicobacter pylori y su consiguiente implicación en el desarrollo de una patología gástrica, especialmente cáncer. En conclución, el 53% de los pacientes que se sometieron a una endoscopía presentaron un resultado positivo para la presencia de Helicobacter pylori (778/1468), porcentaje bastante alto y que correlaciona con el porcentaje de positividad encontrado en la población.
THE ETIOLOGY OF ACUTE RENAL FAILURE IN THE IRANIAN CHILDREN: A SYSTEMATIC REVIEW AND META ANALYSIS

One of the important reasons for the hospitalization of children in intensive care units is to control and support various organ functions; including the function of the kidneys as highly susceptible organs. Acute kidney failure is not a disease but a complex syndrome in which, besides the kidneys, most body's organs are affected. The aim of this study was to evaluate The Etiology of Acute Renal Failure in the Iranian children. Methods: The methods used in this systematic review were based on the Checklist (PRISMA) Guidelines. subgroups were analyzed to determine the heterogeneity by participants' age, year of publication, and Province. Finally, a meta-analysis was performed using STATA14 statistical software. Results: According to the random effect model, the total prevalence of glomerular diseases in 766 acute renal failure patients was 24% (21-27% at a 95% confidence interval, I2 = 96.7%) , the total prevalence of Congenital diseases in 568 acute renal failure patients was 36% (32-39% at a 95% confidence interval, I2 = 98.8%) and the total prevalence of Neurogenic bladder in 253 acute renal failure patients was 17% (13-22% at a 95% confidence interval, I2 = 96.3%). Conclusion: Early diagnosis of Acute Renal Failure in children slows the progression of the disease and delays the final stage of failure, also considering that hemodialysis and kidney transplantation facilities are often available only for children weighing more than 12-10 kg, diagnosing the early and mysterious symptoms of chronic kidney failure (to prevent the progression of kidney failure as the child grows older, as well as to identify genetic diseases in the family and to prevent the birth of more unhealthy children) is of high significance. Key words: Acute Renal Failure, Scorpion sting, Pediatric intensive care units, Prevalence
The Effectiveness of Bibliotherapy on the Fear of the Hospital Environment for Children with Cancer

Background : Cancer and its long-term and painful treatments could have profound psychological impacts on children. On the other hand, the need for frequent hospitalization is accompanied by problems such as the fear of the hospital environment. Therefore, the present study was conducted with the aim of determining the effectiveness of bibliotherapy on the fear of hospital environments in children with cancer. Method: In this semi-experimental study, 20 children with cancer (5 -7 years old) were selected by simple random sampling method in 2016 from Amir Hospital in Shiraz. These cancer patients were assigned to two groups of experimental and control based on random blocks. The research tool was the Hospital Fears Rating Scale. The storytelling was performed for the experimental group in 15 sessions for 30 minutes during two months. Before and after two months of the intervention, the parents in both groups completed the questionnaire. Data were analyzed by SPSS software version 16 using descriptive, independent and paired t-tests. Results : Findings showed that the mean score of fear of children with cancer of hospital environment was significantly different in the experimental group before (26.8 ±5.9) and after the intervention (23.7±5.65, P<0.001). Also, the posttest mean scores of the experimental and control groups (27.5 ±5.58, P=0.001) were significantly different. Conclusion : Bibliotherapy has a positive effect on reducing the fear of hospital environment in children with cancer. Therefore, it is recommended that bibliotherapy be used in the medical environment with children with cancer. Key words: Bibliotherapy, Cancer, Children, Environment, Fear, Hospital
From Dutch Short-Lived to Antarctic Long-Lived Stable Boundary Layers

Stable boundary layers (SBLs) are a common aspect of the earth’s atmosphere and are characterized by a stable density stratification in which the temperature increases with height. This typically occurs during the night, resulting in a short-lived stable boundary layer, or persistently throughout the polar winter, resulting in a longlived stable boundary layer. Due to their associated cold surface temperatures, stable boundary layers can stimulate the formation of radiation fog or frost near the surface, which may negatively impact human activities and result in large economic losses. However, despite their omnipresence, a comprehensive understanding of their dynamical behavior is still lacking.
Working in Psychiatry: Staff Perception of the Brazzaville Hospital and University Center

Background: In Congo-Brazzaville, there is a lake of mental healthcare provider and facilities specialized on psychiatric care: only two psychiatrists and one psychiatric department around the country. Poor appreciation of their role and work environment can negatively impact the esteem of psychiatric staff and lead to stigma and discrimination towards patients. Aims: The study aimed to assess the perception of the staff of the only psychiatric service in Congo. Material and methods: We conducted a cross-sectional descriptive, prospective survey; conducted among the psychiatric staff of the Brazzaville University Hospital in September 2019. An anonymous individual questionnaire was administered to collect: 1) socio-professional data, 2) perceptions (assignment, role, workload and working conditions), and 3) identify the main problems of the service. Averages and frequencies were calculated on Epi info 7.2. 2.6. Results: Thirty out of 42 staff had responded (71.4%); 16 were male and at their first psychiatric assignment (28/30), with an average age of 44.7 ± 7 and seniority of 8.4 ± 8.3 years. Among them: one psychiatrist, two psychologists, and 19 nurses. Their assignment in psychiatry was well perceived in 93.3% (27/30), as well as their role (the importance of psychiatric care and psychiatry). Working conditions were perceived as poor: precarious hygiene (93.3%), cohabitation with dangerous patients (82.1%), heavy workload due to lack of staff (100%). Of their professional future, 23.3% (7/30) were considering leaving. Conclusion: Almost all psychiatric staff had a good perception of their role and psychiatry, but not of the working conditions. Local measures to improve working conditions must be carried out to improve the attractiveness of psychiatry and the quality of care.