Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolic Aspects of Hepatitis C Virus Infection

Hepatitis C virus (HCV) infection is one of the most important causes of cirrhosis and hepatocellular carcinoma (HCC) and has a tremendous impact on public health worldwide. It is estimated that there are more than 170 million people chronically infected with HCV, and 3 to 4 million persons are newly infected annually. The risk for developing cirrhosis 20 years after initial HCV infection among those chronically infected varies between studies, but is estimated at around 10%–15% for men and 1–5% for women. Once cirrhosis is established, the rate of developing HCC is at 1%–4% per year. Approximately 280,000 deaths per year are related to HCV infection. HCV-related end-stage liver disease and HCC have become the leading cause for liver transplantation globally.
Voice therapy : clinical studies

This text reviews the experiences of clinicians in treating the major forms of voice disorders. It aims to teach disorders through concise reviews of the aetiologies, personal information about the dysphonic patient and descriptions of tailored diagnostic and therapeutic approaches used in remediation of a specific type or class of voice dysfunction. It is designed for students who have already mastered the basics of voice disorders and for those beginning to practice therapy.
Trophic interaction modifications: an empirical and theoretical framework

Abstract Consumer–resource interactions are often influenced by other species in the community. At present these ‘trophic interaction modifications’ are rarely included in ecological models despite demonstrations that they can drive system dynamics. Here, we advocate and extend an approach that has the potential to unite and represent this key group of non‐trophic interactions by emphasising the change to trophic interactions induced by modifying species. We highlight the opportunities this approach brings in comparison to frameworks that coerce trophic interaction modifications into pairwise relationships. To establish common frames of reference and explore the value of the approach, we set out a range of metrics for the ‘strength’ of an interaction modification which incorporate increasing levels of contextual information about the system. Through demonstrations in three‐species model systems, we establish that these metrics capture complimentary aspects of interaction modifications. We show how the approach can be used in a range of empirical contexts; we identify as specific gaps in current understanding experiments with multiple levels of modifier species and the distributions of modifications in networks. The trophic interaction modification approach we propose can motivate and unite empirical and theoretical studies of system dynamics, providing a route to confront ecological complexity.
Hipomelanosis de Ito. Un síndrome neurocutáneo heterogéneo y posiblemente infradiagnosticado

Introduccion. La hipomelanosis de Ito (HI) o incontinentia pigmenti achromians es un trastorno neurocutaneo multisistemico que se asocia a complicaciones neurologicas en un alto porcentaje de pacientes. Objetivos. Revisar las caracteristicas mas relevantes en una serie de 14 pacientes con HI. Pacientes y metodos. Se llevo a cabo un estudio retrospectivo en el que se analizaron los siguientes datos: edad, sexo, antecedentes familiares y personales, caracteristicas clinicas y exploraciones complementarias efectuadas. Se presentan nueve mujeres y cinco varones con edades comprendidas entre los 4 meses y los 14 anos. Resultados. Todos los pacientes presentaban anomalias neurologicas, entre las que destaca el retraso psicomotor o mental en 11 (asociado en dos a un comportamiento autista), anomalias neurorradiologicas en siete, microcefalia en tres y crisis epilepticas en dos. Otras complicaciones relevantes fueron las anomalias musculoesqueleticas y oculares (presentes cada una de ellas en nueve pacientes), dentales en seis, facies tosca y pabellones auriculares dismorficos en cuatro pacientes, hipoacusia en cinco y cardiopatia congenita en dos. Como hechos aislados se han observado: atresia de coanas, fisura palatina, dilatacion segmentaria del colon, criptorquidia, hernia inguinal, talla baja, reflujo vesicoureteral y pubarquia prematura. Conclusiones. Dada la ausencia de un marcador biologico que identifique la HI y la existencia de formas clinicas con escasa expresividad cutanea, que en ocasiones pasan desapercibidas o no se consideran suficientemente relevantes para establecer el diagnostico, es posible que esta entidad sea mas frecuente de lo que asumimos y que su prevalencia se infravalore.
Impact de la voie d'accouchement des fœtus en présentation podalique en travail spontané prématuré entre 28 et 32 semaines d'aménorrhée et 6 jours

Objectifs : evaluer l'impact de la voie d'accouchement des grands prematures entre 28 semaines d'amenorrhee (SA) et 32 SA et 6 jours en travail spontane avec une presentation du siege. Avec comme objectif primaire, l'evaluation de la morbidite et de la mortalite a court terme sur l'enfant et objectifs secondaires l'evaluation de la morbidite maternelle mais aussi le devenir des enfants jusqu'a l'âge corrige de 2ans. Materiels et methodes : etude retrospective de 2004 a 2011, sur 49 patientes, comparant 2 populations reparties soit en intention de voie basse (ITVB) soit en intention de cesarienne (ITC) presentant une grossesse simple entre 28 et 32 SA et 6 jours inclus, pour laquelle un accouchement premature avait lieu suite a une mise en travail spontane sur une presentation fœtale podalique. Resultats : 25 patientes etaient traitees en ITVB contre 24 en ITC. Le pH arteriel de naissance est significativement plus bas (p= 0,0391) dans le groupe ITVB avec une mediane a 7,25 [7,16-7,30] contre 7,34 [7,26-7,35] pour les ITC. Il existe une tendance a une augmentation des pathologies intracrâniennes neonatales et des infections profondes maternelles pour les ITC. L'evaluation de la morbidite a 2 ans des enfants est comparable pour les 2 groupes. Conclusion : notre etude montre qu'il n'existe pas d'argument fort pour encourager la cesarienne systematique pour cette population de prematures.
The predictability of a lake phytoplankton community, over time-scales of hours to years.

Forecasting changes to ecological communities is one of the central challenges in ecology. However, nonlinear dependencies, biotic interactions and data limitations have limited our ability to assess how predictable communities are. Here, we used a machine learning approach and environmental monitoring data (biological, physical and chemical) to assess the predictability of phytoplankton cell density in one lake across an unprecedented range of time-scales. Communities were highly predictable over hours to months: model R2 decreased from 0.89 at 4 hours to 0.74 at 1 month, and in a long-term dataset lacking fine spatial resolution, from 0.46 at 1 month to 0.32 at 10 years. When cyanobacterial and eukaryotic algal cell densities were examined separately, model-inferred environmental growth dependencies matched laboratory studies, and suggested novel trade-offs governing their competition. High-frequency monitoring and machine learning can set prediction targets for process-based models and help elucidate the mechanisms underlying ecological dynamics.
Reply: Implication of the liberal use of ART in Nordic countries: should stricter guidelines be created to prevent unnecessary stillbirth and preterm delivery?

Sir, With interest we read the article of Henningsen et al., who compared pregnancy outcomes in singleton pregnancies after ART to singleton pregnancies that were conceived naturally. The authors report a significantly increased risk of stillbirth after ART before a gestational age of 28 weeks. They conclude that in view of the fact that the increased stillbirth risk was observed before 28 weeks only, prevention of stillbirth in the third trimester might be sufficient. We have two comments. First, the authors have acknowledged that a proportion of the cohort of women with ART singleton pregnancies (estimating background rate 1 in 10 (Henningsen et al., 2014)) initially might have had a vanishing twin. They have also acknowledged the subsequent possible implications for early stillbirths in this group. It would be crucial to know what proportion of the singletons after ARTwould be the result from single embryo transfer (SET) or from double embryo transfer (DET). This information is not provided, but may be available to the authors. Moreover, as SET in Scandinavia was introduced well before the end of the study period, the authors might be able to look at trends over this time. Secondly, when the increased perinatal mortality rate before 28 weeks indeed can be linked to the use of ART, we would like to challenge the opinion of the authors on the liberal use of ART in Nordic countries, where . 3% of the babies are conceived after ART, with Denmark leading the way with 4.5% of infants born through ART (Ferraretti et al., 2013). Considering the fact that many couples would conceived naturally when allowed a longer expectant management period we could imagine stricter guidelines around use of ART in Scandinavia to prevent unnecessary stillbirth and preterm delivery.
Antimicrobial screening of Trikatu and Sitopladi Churnas

Ayurvedic system of medicine prescribes a number of crude drugs for longevity of life and for curing various ailments. In the present study we have selected two most commonly used ayurvedic formulations i.e. Trikatu and Sitopladi churnas. which are used against respiratory tract infections. The petroleum ether, acetone, methanolic and aqueous extracts of each plant was tested against Staphylococcus aureus, Streptococcus pyogenes, S. pneumoniae, S. sanguis, S. salivarius, S. mutans, Lactobacillus acidophillus, E.coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, Salmonella typhi, Micrococcus luteus, Bacillus megneterium, Bacillus subtilis, Proteus vulgaris, Candida albicans and it was found that methanolic extracts exhibited the highest degree of activity. Zingiber officinales (tuber) and Piper longum (fruits) produced outstanding antibacterial effect with inhibition zone greater than 20 mm against most of the pathogens. Minimum inhibitory concentration of most effective extract (methanolic) was performed against E. coli, B. subtilis, S. pneumoniae and S. pyogenes whereas P. longum showed best results against E.coli (0.0391 mg/ml) and Z. officinales against B. subtilis (0.0391mg/ml).
Manual for the videofluorographic study of swallowing

Time from stroke onset to videofluoroscopic swallowing study. Full-size table Manual for the Videofluorographic Study of Swallowing. (2nd ed.)PRO-ED. Swallowing disorders occur in all age groups and arise from a variety of medical Manual for the videofluorographic study of swallowing: Second edition. study is particularly useful for identifying the pathophysiology of a swallowing disorder For the original videofluorographic study, three small radiopaque markers The thyroid cartilage is gently mobilized by manual distraction to either side.
The Burden of Alcohol Use

Research shows that multiple factors influence college drinking, from an individual’s genetic susceptibility to the positive and negative effects of alcohol, alcohol use during high school, campus norms related to drinking, expectations regarding the benefits and detrimental effects of drinking, penalties for underage drinking, parental attitudes about drinking while at college, whether one is member of a Greek organization or involved in athletics, and conditions within the larger community that determine how accessible and affordable alcohol is. Consequences of college drinking include missed classes and lower grades, injuries, sexual assaults, overdoses, memory blackouts, changes in brain function, lingering cognitive deficits, and death. This article examines recent findings about the causes and consequences of excessive drinking among college students relative to their non-college peers and many of the strategies used to collect and analyze relevant data, as well as the inherent hurdles and limitations of such strategies.
Prognostic Factors, Treatment, and Survival in Dermatofibrosarcoma Protuberans.

Importance There is limited information regarding the influence of patient demographics, tumor characteristics, and treatment type on the survival of patients with dermatofibrosarcoma protuberans (DFSP). Objective To assess prognostic factors and to evaluate the influence of treatment modality on overall survival of patients with DFSP. Design, Setting, and Participants We examined DFSP using data for 3686 patients with histologically confirmed cases of DFSP diagnosed between 1972 and 2012 from the 18 US regional registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program, with linkage to demographic data from the US Census Bureau for median household income (MHI). The analysis was performed in February 2016. Main Outcomes and Measures The primary outcome measures were tumor characteristics, prognostic factors, and overall survival in months. Results There were 3686 cases of DFSP examined. Older age (hazard ratio [HR], 1.08; 95% CI, 1.06-1.10; P < .001), male sex (HR, 1.97; 95% CI, 1.09-3.55; P = .03), and tumor size (HR, 1.09; 95% CI, 1.01-1.18; P = .04) were significantly associated with poorer overall survival in a controlled analysis. Older age (odds ratio [OR], 1.01; 95% CI, 1.00-1.02; P = .01), male sex (OR, 1.95; 95% CI, 1.57-2.42; P < .001), and black race (OR, 1.78; 95% CI, 1.37-2.32; P < .001) were associated with larger (≥3.0 cm) tumors at presentation. Treatment modality did not influence overall survival; however, differences in patient characteristics affected the treatment received. Older age at presentation (OR, 1.02; 95% CI, 1.01-1.03; P =.01), black race (OR, 1.82; 95% CI, 1.13-2.92; P = .01), large tumor size (OR, 1.15; 95% CI, 1.09-1.21; P < .001), and head or neck location (OR, 4.63; 95% CI, 2.66-8.07; P <.001) increased the likelihood of a patient receiving surgery and radiation over surgery alone. In addition, white patients (OR, 0.51; 95% CI, 0.30-0.87; P=.01), women (OR, 0.53; 95% CI, 0.36-0.78; P <.001), and patients with a higher MHI (OR, 1.27; 95% CI, 1.11-1.46; P <.001) were more likely to receive Mohs micrographic surgery (MMS) over excision. Conclusions and Relevance Age at diagnosis, male sex, and DFSP tumor size appear to be important prognostic factors. Treatment modality did not significantly influence survival; however, patient and tumor characteristics influence treatment modality.
Improving the Odds: Factors that Increase the Likelihood of Four-Year College Attendance Among High School Seniors

] Introduction ] Variables ] Study Design 4 Data Analysis 5 Findings for the Full Sample 6 Findings for the Low-Income Subsample 12 Discussion . 14 Findings that Support or Contradict the Literature 15 Findings that Make New Contributions to the Literature 16 Conclusion 17 References 18 Additional Publications 19 Appendix A: Gallup Interuiew Protoco/. 20 Appendix B: Student Descriptiue Questionnaire Items 32 Figures 1. Basic Research Model. 2 2. Full Research Model 3 Tables 1. SAT Score by Annual Family Income: Sample Design Matrix and Population Distribution . 5 2. Regression Summary of Single Predictors (Full Sample) 7 3. Cross-Tabulation of Counselor's Belief and Students' Plans (Full Sample) 9 4. Factor Summary of Unique Predictors (Full San1ple) 9 5. Variable Summary of Unique Predictors (Full Sample) 10 6. Summary of Significant Single and Unique Predictors of Plans to Attend a Four-Year College (Full Sample) 11 7. Regression Summary of Single Predictors (LowIncome Subsample) 12 8. Factor Summary of Unique Predictors (LowIncome Subsample) 13 9. Variable Summary of Unique Predictors (LowIncome Su bsample) 14 10. Summary of Significant Single and Unique Predictors of Plans to Attend a Four-Year College (Low-Income Subsample) 15
Chronic migraine in women is associated with insulin resistance: a cross‐sectional study

Migraine is a common neurological disorder. It can be divided into episodic migraine (EM) and chronic migraine (CM), based on headache frequency. Some studies have shown that insulin sensitivity is impaired in migraine; moreover, hypertension, diabetes and obesity are common in patients with CM. The aim of this study was to assess serum glucose, insulin levels and insulin resistance (IR) in a sample of episodic migraineurs, chronic migraineurs and non‐pain healthy controls.
Large deletion mutation of SPAST in a multi‐generation family from Sardinia

The hereditary spastic paraplegias (HSP) are characterized by progressive spasticity of the lower limbs, mostly inherited as an autosomal dominant trait. Analyses of large HSP pedigrees could help to better characterize the phenotype due to a single causative mutation. Patients in a seven‐generation kindred carrying a large deletion in SPAST/SPG4 are described.
Sirolimus-Associated Rapid Progression of Leg Ulcers in a Renal Transplant Recipient.

Sirolimus-Associated Rapid Progression of Leg Ulcers in a Renal Transplant Recipient Sirolimus is a mammalian target of rapamycin (mTOR) inhibitor indicated for therapeutic immunosuppression following solid organ transplantation. It has also been shown to decrease skin cancer risk in transplant recipients. We present a case of rapid progression and de novo formation of leg ulcers in a renal transplant recipient coincident with sirolimus therapy.
Diagnosis and Treatment of Uveitis

Section 1: Basic Principles Introduction * The Uvea: Anatomy, Histology and Embryology * Definition, Classification, Etiology and Epidemiology * General Principles and Philosophy Section 2: Principles of Diagnosis and Therapy Diagnosis of Uveitis * Imaging Studies for Uveitis * Treatment of Uveitis-Overview * Corticosteroids * Mydriatic and Cycloplegic Agents * Nonsteroidal Anti-inflammatory Drugs * Immunosuppressive Chemotherapy * Diagnostic Surgery * Therapeutic Vitreoretinal Surgery * Clinical Trials and Evidence-based Medicine in the Medical Management of Uveitis Section 3: The Uveitis Syndromes- Infectious Syphilis * Borreliosis * Bartonella * Tuberculosis * Leptospirosis * Brucellosis * Ocular Whipple's Disease * Rickettsial Diseases * Ocular Leprosy * Herpes viruses * Emergent Viral Infections * Rift Valley Fever * Measles * Rubella * Presumed Ocular Histoplasmosis Syndrome * Candidiasis * Coccidioidomycosis * Cryptococcosis * Sporotrichosis * Toxoplasmosis * Other Vector-Borne Parasitic Infections * Free-living Amebas and Amebiasis * Giardia Lamblia * Trypanosomiasis * Pneumocystosis * Ocular Toxocariasis * Ascariasis * Onchocerciasis * Loiasis * Cysticercosis * Diffuse Unilateral Subacute Neuroretinitis * Schistosomiasis * Ophthalmomyiasis * Ophthalmia Nodosa * Human Immunodeficiency Virus Associated Uveitis Section 4: The Uveitis Syndromes- Masquerade Syndromes Masquerade Syndromes: Malignancies * Masquerade Syndromes: Endophthalmitis * Nonmalignant, Noninfectious Masquerade Syndromes Section 5: The Uveitis Syndromes- Autoimmune Seronegative Spondyloarthropathies * Systemic Lupus Erythematosus * Scleroderma * Giant Cell Arteritis * Adamantiades-Behcet's Disease * Polyarteritis Nodosa * Granulomatosis with Polyangitis (Wegener) (GPA) * Polychondritis * Fuchs' Heterochromic Iridocyclitis * Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria * Sarcoidosis * Tubulointerstitial Nephritis and Uveitis Syndrome * Birdshot Retinochoroidopathy * Sympathetic Ophthalmia * Vogt-Koyanagi-Harada Disease * Multifocal Choroiditis and Panuveitis * Multiple Evanescent White Dot Syndrome * Acute Posterior Multifocal Placoid Pigment Epitheliopathy * Acute Retinal Pigment Epitheliitis * Serpiginous Choroiditis * Subretinal Fibrosis and Uveitis Syndrome * Punctate Inner Choroiditis:Diagnosis and Management * Acute Zonal Occult Outer Retinopathy * Lens-Induced Uveitis * Retinal Vasculitis * Intermediate Uveitis Section 6: Other Medication-Induced Uveitis * Pediatric Uveitis * Pregnancy and Uveitis * Traumatic Uveitis
TRISOMY 18 AND TRISOMY 13 SYNDROMES

The trisomy 18 and trisomy 13 syndromes represent important and common conditions of human aneusomy. Together, their combined prevalence in live-born infants approaches 1 in 4000 births. These syndromes are unique among chromosome disorders as well as the other conditions described in this text since about 90% of children with trisomies 18 and 13 die before their first birthday. Because of this high infant mortality rate, the conditions are sometimes labeled simplistically as “lethal. ” However, about 10% of infants do indeed survive. Regardless of the figures for survival, the parents of the child and the practitioners caring for the family seek an approach to management and health supervision as in any other serious medical disorder. Ongoing support and care by professionals are crucial to a family whose child has an uncertain prognosis. This chapter will provide a concise review of the literature of the syndromes and a plan of management for the primary care of children with trisomies 18 and 13. Keywords: trisomy 19; trisomy 13; Edwards syndrome; Patau syndrome; poor survival; multiple congenital anomalies
Reviews: Glycoprotein IIb/IIIa Receptor Inhibitors in Acute Coronary Syndromes: Conquests and New Challenges

From the *Department of Internal Medicine, Division of Cardiology, and the † Department of Physiology, University of Florida College of Medicine; and the ‡ VA Medical Center, Gainesville, FL. Reprint requests: Karen M. Smith, MD, Department of Medicine, University of Florida College of Medicine, 1600 Archer Rd., P.O. Box 100277 JHMHC, Gainesville, FL 32610. In recent years, the role of the platelet in the pathophysiology of ischemic cardiovascular disease has become increasingly evident, and the use of various platelet-inhibitory drugs has become widespread. One of the most exciting new advances in anti-
Comprehensive Textbook of Genitourinary Oncology

Thoroughly revised for its Third Edition, this volume is the most comprehensive, multidisciplinary text on genitourinary cancers. This edition has two new editors - Frans M.J. Debruyne and W. Marston Linehan - and more than 50 per cent new contributors. Seventeen new chapters cover familial prostate cancer, biology of bone metastases, molecular pathology and biologic determinants, PSA and related kallikreins, needle biopsy, laparoscopic surgical procedures, 3D conformal radiotherapy, hormones and radiotherapy, integration of chemotherapy and other modalities, quality of life after treatment of localized prostate cancer, management of rising PSA after local therapy, the role of surgery in advanced bladder cancer, post-chemotherapy node dissections and resection of metastatic disease, and stem cell transplantation.
Analisis Kepuasan Pasien sebagai Mediasi Pengaruh Kualitas Pelayanan Kesehatan terhadap Citra Rumah Sakit Umum Daerah (RSUD) Arifin Achmad Pekanbaru

Abstract: The purpose of this research is to investigate the relationship between healthcare quality, patient satisfaction and the image of Arifin Achmad Pekanbaru General Hospital, and the mediating effect of patient satisfaction. Healthcare quality in this research was measured using Servqual model from Parasuraman et al. Sample in this research were 100 inpatients who are undergoing treatment at the Arifin Achmad Pekanbaru General Hospital at the time of data collection / interviews conducted in July 2011, with the following criteria: a) Patients had undergone inpatient treatment for a minimum of 2 days. b) Patients was conscious and able to communicate properly. c) Patients are not children. d) Patients are not hospital employees or their families. Hypotheses testing in this research were analysed using Path Analysis. The results indicate that healthcare quality has a positive and significant impact on patient satisfaction and the hospital image. Patient satisfaction has also significant impact on hospital image. Moreover, patient satisfaction appears to play mediating role in relationship between healthcare quality and the image of Arifin Achmad Pekanbaru General Hospital. Keywords: healthcare quality, Patient satisfaction, Hospital image