Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis

Epilepsy is one of the most devastating neurological diseases and despite significant efforts there is no cure available. Occurrence of spontaneous seizures in epilepsy is preceded by numerous functional and structural pathophysiological reorganizations in the brain—a process called epileptogenesis. Treatment strategies targeting this process may be efficient for preventing spontaneous recurrent seizures (SRS) in epilepsy, or for modification of disease progression. We have previously shown that (i) myoinositol (MI) pretreatment significantly decreases severity of acute seizures (status epilepticus: SE) induced by kainic acid (KA) in experimental animals and (ii) that daily post-SE administration of MI for 4 weeks prevents certain biochemical changes triggered by SE. However it was not established whether such MI treatment also exerts long-term effects on the frequency of SRS. In the present study we have shown that, in KA-induced post-SE epilepsy model in rats, MI treatment for 28 days reduces frequency and duration of behavioural SRS not only during the treatment, but also after its termination for the following 4 weeks. Moreover, MI has significant effects on molecular changes in the hippocampus, including mi-RNA expression spectrum, as well as mRNA levels of sodium-MI transporter and LRRC8A subunit of the volume regulated anionic channel. Taken together, these data suggest that molecular changes induced by MI treatment may counteract epileptogenesis. Thus, here we provide data indicating antiepileptogenic properties of MI, which further supports the idea of developing new antiepileptogenic and disease modifying drug that targets MI system.
Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

This review is focused on current state-of-the-art research on electroactive-based materials and their synthesis, as well as their physicochemical and biological properties. Special attention is paid to pristine intrinsically conducting polymers (ICPs) and their composites with other organic and inorganic components, well-defined micro- and nanostructures, and enhanced surface areas compared with those of conventionally prepared ICPs. Hydrogels, due to their defined porous structures and being filled with aqueous solution, offer the ability to increase the amount of immobilized chemical, biological or biochemical molecules. When other components are incorporated into ICPs, the materials form composites; in this particular case, they form conductive composites. The design and synthesis of conductive composites result in the inheritance of the advantages of each component and offer new features because of the synergistic effects between the components. The resulting structures of ICPs, conducting polymer hydrogels and their composites, as well as the unusual physicochemical properties, biocompatibility and multi-functionality of these materials, facilitate their bioapplications. The synergistic effects between constituents have made these materials particularly attractive as sensing elements for biological agents, and they also enable the immobilization of bioreceptors such as enzymes, antigen-antibodies, and nucleic acids onto their surfaces for the detection of an array of biological agents. Currently, these materials have unlimited applicability in biomedicine. In this review, we have limited discussion to three areas in which it seems that the use of ICPs and materials, including their different forms, are particularly interesting, namely, biosensors, delivery of drugs and tissue engineering.
Tablet of Ximenia Americana L. Developed from Mucoadhesive Polymers for Future Use in Oral Treatment of Fungal Infections

The use of biocompatible polymers such as Hydroxypropylmethylcellulose (HPMC), Hydroxyethylcellulose (HEC), Carboxymethylcellulose (CMC), and Carbopol in solid formulations results in mucoadhesive systems capable of promoting the prolonged and localized release of Active Pharmaceutical Ingredients (APIs). This strategy represents a technological innovation that can be applied to improving the treatment of oral infections, such as oral candidiasis. Therefore, the aim of this study was to develop a tablet of Ximenia americana L. from mucoadhesive polymers for use in the treatment of oral candidiasis. An X. americana extract (MIC of 125 μg·mL−1) was obtained by turbolysis at 50% of ethanol, a level that demonstrated activity against Candida albicans. Differential Thermal Analysis and Fourier Transform Infrared Spectroscopy techniques allowed the choice of HPMC as a mucoadhesive agent, besides polyvinylpyrrolidone, magnesium stearate, and mannitol to integrate the formulation of X. americana. These excipients were granulated with an ethanolic solution 70% v/v at PVP 5%, and a mucoadhesive tablet was obtained by compression. Finally, mucoadhesive strength was evaluated, and the results demonstrated good mucoadhesive forces in mucin disk and pig buccal mucosa. Therefore, the study allowed a new alternative to be developed for the treatment of buccal candidiasis, one which overcomes the inconveniences of common treatments, costs little, and facilitates patients’ adhesion.
New Type of Sodium Alginate-g-acrylamide Polyelectrolyte Obtained by Electron Beam Irradiation: Characterization and Study of Flocculation Efficacy and Heavy Metal Removal Capacity

The goals of the paper were first the obtainment and characterization of sodium alginate-g-acrylamide polyelectrolytes by electron beam irradiation in the range of 0.5 to 2 kGy, and second, the evaluation of flocculation efficacy and heavy metal removal capacity from aqueous solutions of known concentrations. Based on sodium alginate concentration, two types of grafted polymers were obtained. Physical, chemical, and structural investigations were performed. Flocculation studies under different stirring conditions on 0.5, 0.1 and 0.2% kaolin suspension were done. The removal capacity of Cu2+ and Cr6+ ions was also investigated. The acrylamide grafting ratio on sodium alginate backbone was found up to 2000% for samples containing 1% sodium alginate and up to 500% for samples containing 2% sodium alginate. Transmittances between 98 and 100% were obtained using, in the flocculation studies, polyelectrolytes containing 2% sodium alginate in concentrations of 0.5 and 1 ppm on kaolin suspension of 0.1 wt %. The polymer concentration was found critical for kaolin suspension of 0.05 and 0.1 wt %. Polymers containing 1% sodium alginate were efficient in Cr6+ ion removal, while those containing 2% in Cu2+ ion removal.
Automatic Morphemic Analysis of Russian Words

The paper considers the task of the morphemic analysis of Russian words and compares the efficiency of several proposed models. These models can be divided into three groups: derivational and inflectional rule-based, probabilistic, and hybrid models. The latter achieved state-of-the-art results of 0.848 F-score on a test set of 500 Russian words. The models use dictionaries of morphs and words and information about the part of speech and other morphological features of the word. Importantly, our solution takes into account synchronic wordformative relations between words. This allows for analyzing words in any grammatical form, as well as previously unseen words. Our system, which we make freely available to the community, also features morphemic annotation of entire texts and search for specified morphs.
Image Sharpness-Based System Design for Touchless Palmprint Recognition

Currently, many palmprint acquisition devices have been proposed, but how to design the systems are seldom studied, such as how to choose the imaging sensor, the lens, and the working distance. This chapter aims to find the relationship between image sharpness and recognition performance and then utilize this information to direct the system design. In this chapter, firstly, we introduce the development of recent palmprint acquisition systems and abstract their basic frameworks to propose the key problems needed to be solved when designing new systems. Secondly, the relationship between the palm distance in the field of view (FOV) and image pixels per inch (PPI) is studied based on the imaging model. Suggestions about how to select the imaging sensor and camera lens are provided. Thirdly, image blur and depth of focus (DOF) are taken into consideration; the recognition performances of the image layers in the Gaussian scale space are analyzed. Based on this, an image sharpness range is determined for optimal imaging. The experiment results are obtained using different algorithms on various touchless palmprint databases collected using different kinds of devices. They could be references for new system design.
A Novel Approach to Improve the Speech Intelligibility Using Fractional Delta-amplitude Modulation Spectrogram

Abstract Speech enhancement is an interesting research area that aims at improving the quality and intelligibility of the speech that is affected by the additive noises, such as airport noise, train noise, restaurant noise, and so on. The presence of these background noises degrades the comfort of listening of the end user. This article proposes a speech enhancement method that uses a novel feature extraction which removes the noise spectrum from the noisy speech signal using a novel fractional delta-AMS (amplitude modulation spectrogram) feature extraction and the D-matrix feature extraction method. The fractional delta-AMS feature extraction strategy is the modification of the delta-AMS with the fractional calculus that increases the sharpness of the feature extraction. The extracted features from the frames are used to determine the optimal mask of all the frames of the noisy speech signal and the mask is employed for training the deep belief neural networks (DBN). The two metrics root mean square error (RMSE) and perceptual evaluation of speech quality (PESQ) are used to evaluate the method. The proposed method yields a better value of PESQ at all level of noise and RMSE decreases with increased noise level.
STUDY OF THE ANTI-HYPERLIPIDEMIC EFFECT OF THE COMBINED ADMINISTRATION OF THREE NATURAL EXTRACTS IN A POLOXAMER-407 HYPERLIPIDEMIC MODEL AND THEIR LC-ESI-MS/MS2 AND HPLC PROFILING

Objective: Dyslipidaemia is considered a high-risk factor for inducing atherosclerosis and cardiovascular diseases (CVDs). This study aims to investigate the anti-hyperlipidemic effect of the co-administration of the ethanol extracts of both ginger (root and rhizome) and leek (leaves and bulbs) in addition to the aqueous extract of gum arabic. Methods: Rats were divided into eight groups: Hyperlipidaemia was induced in rats by a single intraperitoneal injection of Poloxamer 407 (P-407) [1 g/kg], negative control [saline injected], hyperlipidemic control [P-407 injected], positive control [Atorvastatin 70 mg/kg], groups four, five and six received ginger extract (400 mg/kg), leek extract (500 mg/kg) and gum arabic aqueous extract (7.5 g/kg) respectively and groups seven and eight received a co-administration of ginger, leek and gum arabic extracts at doses A and B respectively. Lipid profile was monitored. The profiling of all the tested extracts was performed by LC-ESI/MS and HPLC. Results: A significant anti-hyperlipidemic activity (P<0.05) was seen for group eight among all the tested groups producing ≈54%, 72%, 50% and 72% decrease in the measured parameters total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) respectively. An overall of 56 and 45 compounds were tentatively identified in the ethanol extracts of ginger and leek, respectively. Galactose and arabinose sugars were found to be the major saccharides in gum arabic and glucuronic acid was the major polyuronide part. Conclusion: the co-administration of a group of natural extracts in the given concentration proved to be more effective than the use of synthetic drugs or the use of a single component.
Crystal Gazer

Non-volatile memories (NVM) offer greater capacity than DRAM but suffer from high latency and low write endurance. Hybrid memories combine DRAM and NVM to form scalable memory systems with the promise of high capacity, low energy consumption, and high endurance. Automatically managing hybrid NVM-DRAM memories to achieve their promise without changing user applications or their programming models remains an open question. This paper uses garbage collection in managed languages to exploit NVM capacity while preventing NVM wear out in hybrid memories with no changes to the programming model. We introduce profile-driven write-rationing garbage collection. Allocation sites that produce frequently written objects are predicted based on previous program executions. Objects are initially allocated in a DRAM nursery space. The collector copies surviving nursery objects from highly written sites to a mature DRAM space and read-mostly objects to a mature NVM space.Write-intensity prediction for 15 Java benchmarks accurately places objects in the correct space, eliminating expensive object monitoring from prior write-rationing garbage collectors. Furthermore, our technique exposes a Pareto tradeoff between DRAM usage and NVM lifetime, unlike prior work. Experimental results on NUMA hardware that emulates hybrid NVM-DRAM memory demonstrates that profile-driven write-rationing garbage collection reduces the number of writes to NVM compared to prior work to extend its lifetime, maximizes the use of NVM for its capacity, and achieves good performance.
A Survey of Multimodal Fusion for Identity Verification

With the rapid development of computer and network technology, the digitization and invisibility of people’s identities have become an important feature of today’s highly informationized society. This article introduces the knowledge of multimodal fusion, and lists some commonly used multimodal fusion techniques in the field of identity verification, and puts forward some prospects for the future multimodal fusion identity verification.
Thermal–Mechanical Coupling Behavior of Directional Polymethylmethacrylate under Tension and Compression

In this work, the quasi-static and dynamic mechanical behavior of directional polymethylmethacrylate is investigated under conditions of uniaxial compression and tension. The main purpose of this investigation is to discuss the effect of strain rate and temperature on the deformation characteristics and failure of such material. Research was carried out with the use of an electric universal testing machine and split Hopkinson bars, which were equipped with high- and low-temperature control systems. The experimental methods for studying the tensile and compressive response of polymer materials under different testing conditions were validated by one-dimensional stress wave theory and digital-image correlation technique. The finite deformation stress–strain behaviors of the samples under different loading condition were obtained with a constant temperature ranging from 218 to 373 K. The experimental results showed that the uniaxial tensile and compressive behaviors of directional polymethylmethacrylate under finite deformation are strongly dependent on temperature, decreased tensile and compressive stress of the material under different strain levels, and increased temperature. Meanwhile, the dynamic tensile and compressive stresses of the material are much higher than the quasi-static stresses, showing the strain-rate strengthening effect. Moreover, the tensile and compressive mechanical behavior of directional polymethylmethacrylate has significant asymmetry. Finally, a visco-hyperelastic model is established to predict the rate-dependence mechanical behavior of directional polymethylmethacrylate at different temperatures.
Development of the PEO Based Solid Polymer Electrolytes for All-Solid State Lithium Ion Batteries

Solid polymer electrolytes (SPEs) have attracted considerable attention due to the rapid development of the need for more safety and powerful lithium ion batteries. The prime requirements of solid polymer electrolytes are high ion conductivity, low glass transition temperature, excellent solubility to the conductive lithium salt, and good interface stability against Li anode, which makes PEO and its derivatives potential candidate polymer matrixes. This review mainly encompasses on the synthetic development of PEO-based SPEs (PSPEs), and the potential application of the resulting PSPEs for high performance, all-solid-state lithium ion batteries.
Optical, Electrical and Thermal Properties of Organic–Inorganic Hybrids with Conjugated Polymers Based on POSS Having Heterogeneous Substituents

Preparation of organic–inorganic hybrids with conventional conjugated polymers such as polyfluorene (PF) and poly(3-hexylthiophene) (P3HT) were demonstrated via the facile blending in solution by employing polyhedral oligomeric silsesquioxane (POSS) having heterogeneous alkyl substituents. From the optical measurements, it was shown that the modified POSS derivatives played a critical role in facilitating amorphous state of polymer matrices. Interestingly, although inter-strand interaction decreased after POSS addition in the hybrid films, thermal stability can be enhanced in the presence of the modified POSS with long alkyl chains. Furthermore, it was demonstrated that carrier mobilities through the hybrid film was minimally reduced by POSS. These results suggest that POSS should be a versatile building block to form hybrid with various types of polymers for enhancing durability without loss of electronic properties of organic components.
An opinion on the distribution and behavior of chemicals in response to climate change, with particular reference to the Asia-Pacific region

There is a general lack of knowledge as regards the effects of climate change on pollutant behavior. This is particularly true of the Asia-Pacific Region (APR). This region has major significance in terms of global pollutant emission and also displays a wide variety of environments. This review presents the authors’ opinions on possible implications of climate change for pollutant behavior in the APR. Although differing responses can be expected across the region, there are clear implications as regards the short- and long-term behavior of pollutants. Effects can be predicted through modeling, but further data are required for model calibration. Nevertheless, it can be predicted that climate change will affect processes including global distillation of persistent organic pollutants, airborne transport of heavy metals, half-life of readily degradable pollutants, and eutrophication in water bodies. Particulates are expected to play a central role in mediating the effects of climate change, and successful predictive models will need to be based on particulate-mediated transport and behavior. Climate change also has the potential to cause an increase in the intensity and frequency of harmful algal blooms in aquatic environments throughout the region, with significant implications for supply of both food and drinking water.
Nanochannel-Confined TAMRA-Polypyrrole Stained DNA Stretching by Varying the Ionic Strength from Micromolar to Millimolar Concentrations

Large DNA molecules have been utilized as a model system to investigate polymer physics. However, DNA visualization via intercalating dyes has generated equivocal results due to dye-induced structural deformation, particularly unwanted unwinding of the double helix. Thus, the contour length increases and the persistence length changes so unpredictably that there has been a controversy. In this paper, we used TAMRA-polypyrrole to stain single DNA molecules. Since this staining did not change the contour length of B-form DNA, we utilized TAMRA-polypyrrole stained DNA as a tool to measure the persistence length by changing the ionic strength. Then, we investigated DNA stretching in nanochannels by varying the ionic strength from 0.06 mM to 47 mM to evaluate several polymer physics theories proposed by Odijk, de Gennes and recent papers to deal with these regimes.
Deterioration in the Physico-Mechanical and Thermal Properties of Biopolymers Due to Reprocessing

Biopolymers are an emerging class of materials being widely pursued due to their ability to degrade in short periods of time. Understanding and evaluating the recyclability of biopolymers is paramount for their sustainable and efficient use in a cost-effective manner. Recycling has proven to be an important solution, to control environmental and waste management issues. This paper presents the first recycling assessment of Solanyl, Bioflex, polylactic acid (PLA) and PHBV using a melt extrusion process. All biopolymers were subjected to five reprocessing cycles. The thermal and mechanical properties of the biopolymers were investigated by GPC, TGA, DSC, mechanical test, and DMA. The molecular weights of Bioflex and Solanyl showed no susceptible effect of the recycling process, however, a significant reduction was observed in the molecular weight of PLA and PHBV. The inherent thermo-mechanical degradation in PHBV and PLA resulted in 20% and 7% reduction in storage modulus, respectively while minimal reduction was observed in the storage modulus of Bioflex and Solanyl. As expected from the Florry-Fox equation, recycled PLA with a high reduction in molecular weight (78%) experienced 9% reduction in glass transition temperature. Bioflex and Solanyl showed 5% and 2% reduction in molecular weight and experienced only 2% reduction in glass transition temperature. These findings highlight the recyclability potential of Bioflex and Solanyl over PLA and PHBV.
Starch-Based Flexible Coating for Food Packaging Paper with Exceptional Hydrophobicity and Antimicrobial Activity

Herein, we fabricated a starch-based flexible coating for food packaging papers with excellent hydrophobicity and antimicrobial properties. FTIR (Fourier transform infrared) and XRD (X-ray diffraction) spectra revealed the homogeneous dispersion of the ZnO nanoparticles (NPs) in the composite film within 5% ZnO NP dosage. SEM (scanning electron microscope) and AFM (atomic force microscope) micrographs confirmed the increased roughness on the composite film with the increased dosages of ZnO NPs. Hydrophobic characteristics showed that dramatic enhancement was obtained in the values and stabilities of DCAs (dynamic contact angles) in the resultant film and coated paper. TG (thermogravimetry) results demonstrated the increased thermal stabilities of the composite films. Significantly, a decreased water vapor transmission rate was observed in the coated paper. When 20% guanidine-based starch and 2% CMC (carboxy methyl cellulose) was added, a flexible coating with excellent antimicrobial activity towards Escherichia coli can be obtained. Furthermore, the migration of ZnO NPs into the food simulants was well below the overall migration legislative limit. The resultant starch-based flexible composite film and coated paper established an effective approach to develop a green-based material for food packaging applications.