Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Nasal Allergen Challenge on Dynamic Viscoelasticity of Nasal Mucus

The effects of nasal provocation on the rheologic properties of nasal mucus were investigated in patients with allergic rhinitis provoked by house dust. The elastic modulus (G') and the dynamic viscosity (η') of nasal mucus were determined by an oscillating sphere magnetic rheometer. Before and after the allergen challenge, G' increased, whereas η' decreased with increasing oscillatory frequency; these findings indicate that the nasal mucus under these conditions is a non-newtonian fluid and has the cross-linked gel-like nature typical of mucus. Both G' and η' values after nasal provocation were significantly lower than before. The values of G' and η' after allergen challenge were in the optimal viscoelasticity range for mucociliary transport.
WHAT DO THEY THINK AND FEEL ABOUT GROWTH NOW? REVISITING SMALL BUSINESS MANAGERS ATTITUDES TOWARDS GROWTH (SUMMARY)

What distinguishes successful from unsuccessful entrepreneurs? Scholars have proposed that, by enabling flexible adaptation to a dynamic environment, the entrepreneurial mindset facilitates pursuit of new venture creation. However, the same cognitive adaptability that is attributed to the entrepreneurial mindset, and deemed responsible for the relentless persistence to which many entrepreneurs ascribe their success, can also lead to undue persistence and escalation of commitment under slightly less favorable circumstances. Building on regulatory focus theory, we examine the conditions under which the entrepreneurial mindset can go from strength to weakness, transforming the entrepreneurial mindset from a core competency that encourages perceptual and behavioral readiness into a core rigidity that is susceptible to escalation of commitment.
Implementing the patient-centered medical home in residency education

Background: In recent years, physician groups, government agencies and third party payers in the United States of America have promoted a Patient-centered Medical Home (PCMH) model that fosters a team-based approach to primary care. Advocates highlight the model′s collaborative approach where physicians, mid-level providers, nurses and other health care personnel coordinate their efforts with an aim for high-quality, efficient care. Early studies show improvement in quality measures, reduction in emergency room visits and cost savings. However, implementing the PCMH presents particular challenges to physician training programs, including institutional commitment, infrastructure expenditures and faculty training. Discussion: Teaching programs must consider how the objectives of the PCMH model align with recent innovations in resident evaluation now required by the Accreditation Council of Graduate Medical Education (ACGME) in the US. This article addresses these challenges, assesses the preliminary success of a pilot project, and proposes a viable, realistic model for implementation at other institutions.
On the Nexus of Monetary Policy and Financial Stability: Is the Financial System More Resilient?

Monetary policy and financial stability are closely intertwined, and the resilience of the financial system carries weight in this relationship. This paper explores whether the financial system is more resilient as a result of the G20’s post-crisis agenda for financial regulatory reform. It summarizes the agenda’s key measures and implementation schedules, both internationally and in Canada, reviews the effectiveness of the reform measures in preventing and addressing financial imbalances, and outlines outstanding issues. It finds that, to date, there is evidence that the G20’s reform measures are increasing financial system resilience globally, especially in the banking sector. Yet, implementation is still ongoing, and it may be too early to judge how the reform measures are interacting with one another. In Canada, the resilience of the financial system is being enhanced by the ongoing implementation of more-rigorous global regulatory and supervisory standards. Consequently, the likelihood and impact of severe financial stress in the future should be reduced, supporting the primary focus of monetary policy on achieving its 2 per cent inflation target.
Shaping a holistic national innovation system. Riigi tervikliku innovatsioonisüsteemi kujundamine

For the sustainable economic development of a state the functioning national innovation system (NIS) is needed. NIS covers different government policies (for instance, education policy, R&D policy innovation support to business sector, intellectual property protection, public procurement policy, etc.). All these policies have to be integrated in a holistic system through innovation policy enabling the functioning different policies in mutual relationships smoothly and effectively for sustainable economic development. The goal of this article is to highlight the role of innovation policy in shaping a holistic NIS. The first part of the article deals with the need for public sector intervention in innovation processes and problems resulting from it. In the second part a holistic NIS model that reflects the role of innovation policy is developed and presented. The third part deals with the structure of innovation policy based on a holistic NIS model
Study on prognosis and health management for the liquid tank

For a new generation of spaceflight launch site online air supply mode, new health status of the equipment is difficult to effectively evaluate the single sample problem, put forward a kind of equipment based on hidden markov state of health management and prediction method; The method use the history of equipment monitoring data hid-den markov health status evaluation model was constructed, based on different observation sequence and the pre-diction accuracy of the simulation under different observation times, determine the optimal model parameters, and the real-time monitoring data generation into the model, according to the model, the calculation results from the minimum to judge the health status of the equipment. Finally, the current data and historical data fitting, estimate the system safe and reliable life, through the actual test, this method is effective to solve the single sample equipment health assessment.
Expression and Function of Brain Specific Small RNAs

Small non-messenger RNAs (snmRNAs) are a heterogeneous group of non-coding RNAs with a variety of regulatory functions including regulation of protein expression and guidance in RNA modifications. They are actively being investigated in Archaebacteria, yeast, invertebrates and mammals. Brain-specific snmRNAs have been identified in mammals and they seem to contribute to neuronal differentiation during development and to brain functions subserving learning and memory. Here we review the current knowledge of the properties, expression and functions of three groups of brain-specific snmRNAs: small nucleolar RNAs, BC1/BC200 RNAs and microRNAs.
An Examination of the Effect of Advertising and Trade Name of Bank Melli Iran on Customer Attitude: A Case Study of Bank Melli Iran- Kohgiluyeh and Boyer-Ahmad Province

The present study is aimed at examining the effects of advertising and trade name of Bank Melli Iran- Kohgiluyeh and Boyer-Ahmad Province on customer attitudes. The research hypotheses test the effect of two variables, namely advertising and trade name, on customers’ attitudes. Furthermore, the research method is of a descriptive-correlation type and statistical population is composed of all the customers of Bank Melli Iran in Kohgiluyeh and Boyer-Ahmad Province. Also, the research statistical sample, which is selected using multi-stage cluster sampling, consists of a total of 175 customers from 10 branches of Bank Melli Iran- Kohgiluyeh and Boyer-Ahmad Province. The research instrument is a questionnaire encompassing 62 questions which tests customer attitude (6 Qs), advertising (16 Qs), and trade name (30 Qs). Moreover, to determine reliability of the research instrument the use is made of Alpha Cronbach’s in SPSS 17. It should also be noted that to test hypotheses the use is made of linear regression. According to the research findings, advertising and trade name have a positive and significant effect on customer attitude. Also, of advertising and trade name elements, magazine and perceived value, respectively, have the highest significant effect on customer attitude. DOI: 10.5901/mjss.2016. v7n4S1p34
A Study on Intention of Use e-Procurement Systems for Public Institutions User

This study examined the usage intention for electronic e-Government procurement services among Public Institution Procurement Managers. The unified theory of acceptance and use of technology (UTAUT) model and the task–technology fit (TTF) model were combined to establish a study model. An hypothesis was formed and verified using SMART PLS. The results show that the UTAUT factors examined in this study effort expectance, social influence, and facilitating conditions influence usage intention. This study is significant in applying both the TTF and UTAUT models with strong explanatory power and identifying the characteristics of the tasks and technology that are required for the use of e-Procurement systems.
A dynamic soft constraint method for thermostatically controlled appliances scheduling

Demand side attracts large attention in smart grid for energy efficiency and demand response, and thermostatically controlled appliances (TCAs) are the most potential resources. TCAs scheduling is a basic tool to utilize the flexibility of TCAs to achieve payment savings or peak reduction for users. Current research usually models the users' comfort a hard constraint in TCAs scheduling, which may fail to generate scheduling commands in abnormal situations, i.e. the hard constraint is deviated. To overcome this problem, a dynamic soft constraint method is proposed to enable the scheduling tool work in any situation. This proposed method considers correction process and consists of two techniques: a soft constraint and a dynamic comfort zone. In normal situations, the dynamic soft constraint is equivalent to the hard constraint, while in abnormal situations, it can still work and pull the temperature back to the comfort zone to limit the deviations. Therefore, the dynamic soft constraint method makes the TCAs scheduling more robust and adaptive to various situations. Both normal and abnormal situations are simulated to verify this new method.
Prevalence of metabolic syndrome in young patients with acute MI: does the Framingham Risk Score underestimate cardiovascular risk in this population?

To assess the prevalence of metabolic syndrome (MS) and estimates of global risk by Framingham Risk Score in young subjects with acute myocardial infarction (MI), we assessed metabolic parameters and global risk assessment in 165 consecutive subjects who presented with myocardial infarction prior to 45 years of age. Nearly 80% of subjects were overweight or obese and at least one cardiovascular risk factor was present in 96% of patients. MS with or without overt diabetes was present in nearly two thirds of subjects. Excluding subjects with diabetes, the mean 10-year Framingham Risk Score estimate in the total cohort was 9. 3%, with only 17. 1% of subjects having a 10-year risk greater than 20%. Only 28% of subjects with MS had a Framingham Risk Score greater than 20%. Although MS is present in nearly two thirds of young patients with premature myocardial infarction, the Framingham Risk Score appears to underestimate global cardiovascular risk in this population.
Hemodynamic and metabolic effects of activities of the adrenergic beta receptor in physical exercise.

The hemodynamic and metabolic effects of β-adrenergic blockade by the use of propranolol has been studied to clarify the physiological significance of β-adrenergic receptor activities during exercise in man and animals. Seven healthy men and twelve thyrotoxic patients were the subjects in this study. All these subjects were examined on bicycle ergometer at a moderate work load for 10 min. in a supine position. No significant changes of hemodynamic parameter induced by P. was observed in healthy men, but in patients group, significant decrease of systolic blood pressure and heart rate were observed at rest. Inhibitory effects of P. on heart rate, systolic blood pressure and cardiac work (M.T.T.I.) were marked during exercise in both group. A11 the metabolic effects including oxygen consumption, plasma pyruvate, lactate and XL production were suppressed with P. in both groups. Mobilization of NEFA induced by exercise were also modified, but plasma glucose was kept invariable during the experimental course. Oxygen debt showed a slight increasing tendency in both groups after P. adm. But the changes were not remarkable. Moreover, in attemt to analyze more precisely these metabolic changes in exercising time, author had animal experiments using rats and made exercise test. In rats treated with P., the plasma lactate concentration did not so increase and the glycogen contents in skeletal and heart muscle were not reduced by swimming exercise probably due to blocking on the activation of phosphorylase. But it was found invariably to reduce the glycogen contents in the liver regadress of pretreatment with P. Plasma NEFA in animals showed the similar pattern to that of man, but no marked triglyceride changes in heart and epididymal fat pad were observed. For the purpose of investigating whether β-receptor has any influence on the disappearance rate of lactate, author infused 1 mol of L(+) sodium lactate at the rate of 9 mg/kg/min into the femoral vein of 8 anesthetized dogs, the plasma lactate concentration in a arterial blood was measured at a constant time interval before and after P. adm. It has been demonstrated that P. promote the disappearance rate of lactate from blood in this experiment. It is concluded that β-adrenergic receptor play an important role on the hemodynamic and the metabolic changes to muscular exercise and the mechanisms have been discussed.
Prevention of Bleomycin-Induced Lung Fibrosis in Mice by a Novel Approach of Parallel Inhibition of Cyclooxygenase and Nitric-Oxide Donation Using NCX 466, a Prototype Cyclooxygenase Inhibitor and Nitric-Oxide Donor

Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donors (CINODs) are designed to inhibit COX-1 and COX-2 while releasing NO. COX inhibition is responsible for anti-inflammatory and pain-relieving effects, whereas NO donation can improve microcirculation and exert anti-inflammatory and antioxidant actions. In an in vivo mouse model of bleomycin-induced lung fibrosis, we evaluated whether a prototype CINOD compound, (S)-(5S)-5,6-bis(nitrooxy)hexyl)2-(6-methoxynaphthalen-2-yl)propanoate (NCX 466), may show an advantage over naproxen, its congener drug not releasing NO. Bleomycin (0.05 IU) was instilled intratracheally to C57BL/6 mice, which were then treated orally with vehicle, NCX 466 (1.9 or 19 mg/kg), or an equimolar dose of naproxen (1 or 10 mg/kg) once daily for 14 days. Afterward, airway resistance, assumed as lung stiffness index, was assayed, and lung specimens were collected for analysis of lung inflammation and fibrosis. NCX 466 and naproxen dose-dependently prevented bleomycin-induced airway stiffness and collagen accumulation. NCX 466, at the highest dose, was significantly more effective than naproxen in reducing the levels of the profibrotic cytokine transforming growth factor-β and the oxidative stress markers thiobarbituric acid reactive substance and 8-hydroxy-2′-deoxyguanosine. NCX 466 also decreased myeloperoxidase activity, a leukocyte recruitment index, to a greater extent than naproxen. A similar inhibition of prostaglandin E2 was achieved by both compounds. In conclusion, NCX 466 has shown a significantly higher efficacy than naproxen in reducing lung inflammation and preventing collagen accumulation. These findings suggest that COX inhibition along with NO donation may possess a therapeutic potential in lung inflammatory diseases with fibrotic outcome.
Lung weight parallels disease severity in experimental coccidioidomycosis

Evidence provided by histopathological study of lesions is a valuable adjunct for evaluating chemotherapeutic efficacy in experimental animal models, In addition, this should be correlated with a measure of disease severity in the same animal. The latter could be obtained by homogenization of infected organs and quantitative enumeration of viable cells of the etiological agent, but this would preclude histopathological studies in the same animal. Progression of disease in pulmonary infection is associated with replacement of air space by fluid, cells, and cellular debris. Therefore, an increase in lung weight should reflect severity of disease. Results with the murine model of coccidioidomycosis demonstrate that increasing lung weight parallels the increasing census of fungus cells in the lungs of both treated and nontreated infected mice. This was supported with evidence obtained from microscopic studies of lesions indicating that specific chemotherapy limited spread of the infection and inhibited multiplication of the fungus in the lung. Therefore, lung weight can be used as a measure of disease severity in the murine model of coccidioidomycosis.
Accountability and social impact measurement for a third sector supported housing organisation

i Acknowledgements . iii Table of contents . v List of figures . xi List of tables . xii List of appendices . xii Abbreviations . xiii Section A: Introduction and theoretical perspective . 14 Chapter 1: Introduction . 15 1.
Evidence-based medicine is affordable: the cost-effectiveness of current compared with optimal treatment in rheumatoid and osteoarthritis.

OBJECTIVE To determine the cost-effectiveness of averting the burden of disease. We used secondary population data and metaanalyses of various government-funded services and interventions to investigate the costs and benefits of various levels of treatment for rheumatoid arthritis (RA) and osteoarthritis (OA) in adults using a burden of disease framework. METHOD Population burden was calculated for both diseases in the absence of any treatment as years lived with disability (YLD), ignoring the years of life lost. We then estimated the proportion of burden averted with current interventions, the proportion that could be averted with optimally implemented current evidence-based guidelines, and the direct treatment cost-effectiveness ratio in dollars per YLD averted for both treatment levels. RESULTS The majority of people with arthritis sought medical treatment. Current treatment for RA averted 26% of the burden, with a cost-effectiveness ratio of dollar 19,000 per YLD averted. Optimal, evidence-based treatment would avert 48% of the burden, with a cost-effectiveness ratio of dollar 12,000 per YLD averted. Current treatment of OA in Australia averted 27% of the burden, with a cost-effectiveness ratio of dollar 25,000 per YLD averted. Optimal, evidence-based treatment would avert 39% of the burden, with an unchanged cost-effectiveness ratio of dollar 25,000 per YLD averted. CONCLUSION While the precise dollar costs in each country will differ, the relativities at this level of coverage should remain the same. There is no evidence that closing the gap between evidence and practice would result in a drop in efficiency.
Arabic Sentiment Analysis: A Survey

Most social media commentary in the Arabic language space is made using unstructured non-grammatical slang Arabic language, presenting complex challenges for sentiment analysis and opinion extraction of online commentary and micro blogging data in this important domain. This paper provides a comprehensive analysis of the important research works in the field of Arabic sentiment analysis. An in-depth qualitative analysis of the various features of the research works is carried out and a summary of objective findings is presented. We used smoothness analysis to evaluate the percentage error in the performance scores reported in the studies from their linearly-projected values (smoothness) which is an estimate of the influence of the different approaches used by the authors on the performance scores obtained. To solve a bounding issue with the data as it was reported, we modified existing logarithmic smoothing technique and applied it to pre-process the performance scores before the analysis. Our results from the analysis have been reported and interpreted for the various performance parameters: accuracy, precision, recall and F-score.
A novel mutation of the androgen receptor gene in familial complete androgen insensitivity syndrome

4146 Abstract. – OBJECTIVE: Androgen insensitivity syndrome (AIS) is characterized by androgen receptor (AR) dysfunction. Its main characteristic is a female phenotype in an individual with a 46, XY karyotype. The molecular basis of this disorder was investigated in two individuals with familial AIS. PATIENTS AND METHODS: The diagnoses of the two individuals were confirmed using ultrasonography, hormonal analysis, operative findings, and a histopathological study. Blood samples were collected, and the AR genes were analyzed using PCR and direct sequencing. RESULTS: Clinical and laboratory testing confirmed the two individuals’ diagnoses of CAIS. DNA sequencing analysis of the genomes of these patients revealed a novel mutation of c.2107T > C in exon 4 of the AR gene, which results in a transformation of the protein p.S703P. The individuals’ mother possesses a heterozygous allele, implying that she is a heterozygous carrier of the mutant gene. CONCLUSIONS: These findings suggested that this previously undescribed novel mutation of the AR gene is the cause of CAIS in this family.
Race and Method of Suicide: Culture and Opportunity

Abstract The present study assesses the link between choice of violent methods of suicide and race from the standpoint of two perspectives: differential socio-acceptability and differential availability. To the extent that African Amercians form a subculture of violence, and are more exposed to violence, we would expect them to choose violent methods of suicide. Data are from the 1990 mortality detail file of the U.S. Public Health Service and correspond to 19,580 male suicides. The results of a multivariate logistic regression analysis indicate that African Americans are 2.24 times more likely than Caucasians to choose violent methods of suicide. Although they are less likely to own firearms, African Americans are more likely than Caucasians to choose violent methods of suicide.
The modified capon approach in the task of binary FSK-signals demodulation

This paper presents an algorithm of digital filtration based on the modified Capon approach. An algorithm is used in the task of FSK-signals demodulation. The filter coefficients correspond to an information-optimal solution to the problem of minimizing the output linear filter dispersion. It is shown that the method is efficient in the conditions of additive noises and inexact knowledge of the central signal frequency spectrum. Proposed algorithm can be efficiently realized on the base of programmable logic for work in a real-time rate.