Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of the effects of topical and systemic atropine sulfate on intraocular pressure and pupil diameter in the normal canine eye.

OBJECTIVE To compare the effects of topical 1% atropine sulfate and systemic 0.1% atropine sulfate on the intraocular pressure (IOP) and horizontal pupil diameter (HPD) in the canine eye. PROCEDURES Four groups, each containing 10 dogs of varying age, breed, and sex were treated as follows: (i) One 30 μL drop of topical 1% atropine sulfate was applied unilaterally in each dog, (ii) A control group, one drop of 0.9% saline was used, (iii) 0.06 mg/kg atropine sulfate was given by intramuscular injection, and (iv) Control with saline injected intramuscularly. In all groups, IOP and HPD were measured every 5 min over 60 min. RESULTS Topical atropine significantly increased IOP in the treated eye with no change in the untreated eye. A maximum increase in IOP from 17.7 ± 3.1 to 20.3 ± 3.1 mmHg (14.7% increase) was obtained 23.0 ± 14.3 min post-treatment. Maximal HPD of 12.1 ± 1.7 mm in the treated eye occurred 46.5 ± 6.3 min after treatment, with no increase in the untreated eye. Systemic atropine caused an increase in IOP in both eyes, showing a maximum at 15.5 ± 10.6 min post-treatment with an IOP of 17.3 ± 4.6 mmHg in the right eye and 17.1 ± 5.2 mmHg in the left eye (21.8% increase in the right eye and 21.6% in the left eye). Maximal HPD was noted in both eyes 30.0 ± 11.6 min after treatment. CONCLUSIONS Atropine sulfate causes a significant increase in IOP when given both topically and by intramuscular injection. It should be used with caution, or indeed avoided entirely, in dogs with glaucoma or in those with a predisposition to the condition.
Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor.

Oxygen occupies a central role in the maintenance of life as we know it, perhaps most prominently in aerobic metabolism, where O2 serves as the terminal electron acceptor in oxidative phosphorylation. However, oxygen transport by simple diffusion becomes limiting as organisms become larger andmore active. Tomaintain oxygen homeostasis, higher eukaryotes have adopted specialized mechanisms to enhance O2 uptake and distribution. The resulting respiratory and circulatory systems are dynamic, capable of responding to changes in oxygen availability on either a local or organismal level. Though some oxygen-dependent responses rely on the activity of specialized oxygen-sensing cells, conserved oxygen-responsive pathways are expressed in almost every mammalian cell. In fact, this ability of individual cells to sense and respond to changes in oxygen availability is critical for many developmental, physiological, and pathological processes. Unlike the rapid responses to changes in oxygen availability, which can be mediated through posttranslational modifications or membrane depolarization (for review, see Lopez-Barneo et al. 2001), this ubiquitous hypoxic response pathway involves changes in gene expression that occur over several hours. These changes are mediated in part through the induction of hypoxia-inducible transcription factors, the regulatory components of which can also be found in simpler eukaryotes such as fruit flies and nematodes.
Tracheal Intubation in Ambulatory Surgery Patients: Using Remifentanil and Propofol Without Muscle Relaxants

Using alfentanil followed by an anesthetic induction dose of propofol provides adequate conditions for tracheal intubation without neuromuscular relaxants.Remifentanil, which has a clinical onset similar to that of alfentanil, has not been investigated for this indication. Accordingly, 80 ASA physical status I and II premedicated outpatients were randomly assigned to one of four groups (n = 20/group). Remifentanil 1, 2, 3, or 4 micro g/kg (Groups I-IV, respectively) was infused intravenously over 90 s. Sixty seconds after beginning the remifentanil infusion, propofol 2 mg/kg was infused over 5 s. Ninety seconds after the administration of propofol, laryngoscopy and tracheal intubation were attempted and graded. Clinically acceptable intubating conditions (i.e., jaw relaxed, vocal cords open, and fewer than two coughs in response to intubation) were observed in 35%, 75%, 100%, and 95% of patients in Groups I-IV, respectively. Clinically acceptable intubating conditions were significantly (P < 0.05) less likely to occur in Group I compared with all other groups. Excellent intubating conditions (i.e., vocal cords open, no movement in response to intubation) were observed in 30%, 50%, 80%, 80% of patients in Groups I-IV, respectively. Overall conditions at intubation were significantly (P < 0.05) better in Groups III and IV compared with Groups I and II. The mean time to resumption of spontaneous ventilation after induction was <5 min in all groups. No patient manifested clinically significant muscle rigidity. The mean arterial pressure decreased 16%, 20%, 28%, 26% immediately before tracheal intubation in Groups I-IV, respectively. No patient was treated for hypotension or bradycardia. In conclusion, healthy, premedicated patients with favorable airway anatomy can be reliably intubated with good or excellent conditions 90 s after the administration of remifentanil 3-4 micro g/kg and propofol 2 mg/kg. Implications: Remifentanil 3 micro g/kg and propofol 2 mg/kg co-administered intravenously may reliably provide adequate conditions for tracheal intubation in healthy patients without neuromuscular relaxants. This combination of drugs may allow the rapid return of spontaneous ventilation.
Fintech: Creative Innovation for Entrepreneurs

: The article studies the impact of Fintech on entrepreneurship in Arabic region by using Crowdfunding platforms as the field of study. The article focuses on Arabic Crowdfunding platforms . The population of (12) platforms consist of: individuals, entrepreneurs, investors, employees at Crowdfunding platforms. Descriptive and quantitative approach used in this article, and a questionnaire used as a tool to collect primary data . The results indicate an impact for Fintech on entrepreneurship in general and obvious obstacles to use it widely in Arabic region cause of legislations or e-payments. The article recommended more awareness for innovative products and services such as Fintech, Crowdfunding and adopting the culture of e-business models. Also the article promoting the process of developing regulations that organize e-business models, especially Fintech and Crowdfunding, the use of modern communication technology to serve the development of society, more interest to innovation and creativity as a key factor for entrepreneurial success.
The influence of physician practice behaviors on patient satisfaction.

BACKGROUND Previous research on the relationship between physician behavior and patient satisfaction has not always used standardized terminology and instruments to measure physician behavior. The Davis Observation Code (DOC) provides a reliable and valid means of analyzing clinically relevant units of physician behavior. The units of behavior can then be related to patient satisfaction. METHODS One hundred new patients randomly assigned to receive care from primary care residents at a university medical center outpatient facility were evaluated. Before seeing their physicians, patients completed a previsit questionnaire to determine their general level of satisfaction with health care. During the visit, the encounter was videotaped and physician behavior characterized using DOC. After the appointment, patients completed a visit-specific satisfaction questionnaire. Multiple regression analysis was used to model the visit-specific satisfaction variables in terms of DOC measurements. RESULTS Total visit-specific satisfaction was positively related to previsit satisfaction (P < or = .05) and to time spent on health education (P < or = .001), physical examination (P < or = .05), and discussion of treatment effects (P < or = .01). There was a negative relationship with time spent on history taking (P < or = .01). Slightly more than 25% of the variability in satisfaction was explained by these five variables (R2 = .26). The general, humaneness, and quality/competence subscales of visit-specific satisfaction were also positively related to health education, physical examination, and treatment effects and negatively related to history taking. CONCLUSIONS Patients are most satisfied with medical visits in which they talk about their specific therapeutic interventions, are examined, and receive health education. Extended general discussion of medical history is negatively related to satisfaction.
Preliminary data suggestive of a novel translational approach to mesothelioma treatment: imatinib mesylate with gemcitabine or pemetrexed

Background: Malignant mesothelioma is a cancer which is refractory to current treatments. Imatinib mesylate is a selective inhibitor of tyrosine kinases such as bcr-abl, c-Kit, c-Fms and platelet derived growth factor receptor β (PDGFRβ). PDGFRβ is often overexpressed in mesothelioma cells and is a therapeutic target for imatinib in some solid tumours. A study was undertaken to assess whether imatinib alone or combined with chemotherapeutic agents may be effective for treating mesothelioma. Methods: Cultures from mesothelioma MMP, REN and ISTMES2 cell lines were treated with imatinib alone or in combination with a chemotherapeutic agent. Results: Imatinib induced cytotoxicity and apoptosis selectively on PDGFRβ positive mesothelioma cells via blockade of receptor phosphorylation and interference with the Akt pathway. Of the chemotherapeutic agents tested in combination with imatinib, a synergistic effect was obtained with gemcitabine and pemetrexed. Conclusions: This study provides a rationale for a novel translational approach to the treatment of mesothelioma which relies on enhancement of tumour chemosensitivity by inhibition of Akt.
Optimization of a FES Cycling Neuroprosthesis on Stroke Patients by Means of the Left and Right Crank Measurements

The use of functional electrical stimulation (FES) is a well established method in the rehabilitation of stroke patients. In particular, a bilateral movement such as cycling induced by FES would be crucial for these patients who had an unilateral motor impairment and had to recover an equivalent use of the limbs. To improve the rehabilitative effects of the FES cycling, a metrologically qualified cycle-ergometer was used, so that the left and right crank torque values are measured in real-time. Three protocols were evaluated. First, healthy subjects performed voluntary pedaling. Second, healthy subjects were stimulated one muscle individually to study the contribution of each single muscle to the cycling. Third, stroke patients executed a complete FES cycling trials. Results demonstrated that the proposed sensors could be successfully used to monitor online the unbalance of the cycling. Single muscle tests showed that only the quadriceps and the hamstrings provided a significant contribution to the crank torque. Patient trials confirmed the difficulty for stroke subjects to carry out symmetrical cycling. The use of the proposed sensors, hence, could offer a good signal for biofeedback neuroprostheses and for closed loop controllers.
Commentary on "The role of the large airways on smooth muscle contraction in asthma".

to the editor: Permutt ([4][1]) in his viewpoint article states that in asthmatics at TLC after albuterol, when airways are as dilated as they can get, “the smaller the… diameters of the… large airways, the smaller was the FEV1/FVC% predicted” and that dynamic hyperinflation resulted from
Transformation in Micrococcus lysodeikticus.

SUMMARY: Phage N6 lysates of Micrococcus lysodeikticus and Sarcina lutea were very viscous and were found to mediate genetic transfer of an adenine marker (ade+) to adenine-dependent strains of M. lysodeikticus. The transfer activity of these lysates was found to reside in a high molecular weight DNA fraction rather than in the phage particles themselves. DNA that was isolated and purified from phage lysates and lysozyme-treated cells was shown to possess transforming activity. Recipient competence was maximal during late logarithmic growth (14-18 hr). The cell density of the transfer suspension was optimum at about 107 colony forming units/ml. Transformants were recovered after 1 hr exposure to DNA and continued to increase in number up to 6 hr. Transformants appeared in higher frequencies on Difco agars that were less purified. Under optimal conditions, transformation frequencies up to several percent per colony forming unit were obtained. All strains of M. lysodeikticus tested (ATCC 4698, ATCC 15801, CCM 1335, PU, UM, WRU, ISU) could serve as donors of the ade+ marker. All strains, except ATCC 4698, were competent recipients of the adenine marker.
N‐Terminal domain of HTLV‐I integrase. Complexation and conformational studies of the zinc finger

The HTLV‐I integrase N‐terminal domain [50‐residue peptide (IN50)], and a 35‐residue truncated peptide formed by residues 9–43 (IN35) have been synthesized by solid‐phase peptide synthesis. Formation of the 50‐residue zinc finger type structure through a HHCC motif has been proved by UV‐visible absorption spectroscopy. Its stability was demonstrated by an original method using RP‐HPLC. Similar experiments performed on the 35‐residue peptide showed that the truncation does not prevent zinc complex formation but rather that it significantly influences its stability. As evidenced by CD spectroscopy, the 50‐residue zinc finger is unordered in aqueous solution but adopts a partially helical conformation when trifluoroethanol is added. These results are in agreement with our secondary structure predictions and demonstrate that the HTLV‐I integrase N‐terminal domain is likely to be composed of an helical region (residues 28–42) and a β‐strand (residues 20–23), associated with a HHCC zinc‐binding motif. Size‐exclusion chromatography showed that the structured zinc finger dimerizes through the helical region. Copyright © 2000 European Peptide Society and John Wiley & Sons, Ltd.
CO2 sensitivity of Southern Ocean phytoplankton

The Southern Ocean exerts a strong impact on marine biogeochemical cycles and global air‐sea CO2 fluxes. Over the coming century, large increases in surface ocean CO2 levels, combined with increased upper water column temperatures and stratification, are expected to diminish Southern Ocean CO2 uptake. These effects could be significantly modulated by concomitant CO2‐dependent changes in the region's biological carbon pump. Here we show that CO2 concentrations affect the physiology, growth and species composition of phytoplankton assemblages in the Ross Sea, Antarctica. Field results from in situ sampling and ship‐board incubation experiments demonstrate that inorganic carbon uptake, steady‐state productivity and diatom species composition are sensitive to CO2 concentrations ranging from 100 to 800 ppm. Elevated CO2 led to a measurable increase in phytoplankton productivity, promoting the growth of larger chain‐forming diatoms. Our results suggest that CO2 concentrations can influence biological carbon cycling in the Southern Ocean, thereby creating potential climate feedbacks.
Information Exchange Methods and Disruptions in Wood Supply Chains

Dependency of accurate and timeliness information is increasing in supply chains. A disruption in information exchange in supply chain can cause severe repercussions to the flow of materials within it. This paper is addressing this gap by assessing the information exchange methods and their disruption risks wood supply chains of an international pulp and paper manufacturer. In this study we illustrate the importance of different information exchange methods as well as the vulnerability reflected to the chain by the possible disruptions of them. The main risk identified by the interviewees raised from information intensive the logistics systems. Internet and phone connections as well as personal relations were found to be essential for fluent information exchange.
An Active Learning Framework Incorporating User Input For Mining Urban Data A Case Study in Dublin , Ireland

Analyzing and detecting events from ubiquitous sensors across the city has been an important goal in recent years. Different techniques that are able to automatically detect events by monitoring urban sensor’s data have been efficiently applied in several smart cities to improve the citizens everyday life. However, the analysis of such voluminous data streams often interferes with several constraints that arise in smart cities scenarios. For example it is impossible to hire human oracles that will monitor each data stream continuously to provide knowledge to these models and to annotate past instances. Thus, the development of novel techniques is required in order to build efficient supervised learning models that will be able to cope with urban data deluge. Our approach makes the following contributions: (i) we formulate the problem of building supervised learning models efficiently by incorporating streaming input from urban data, and (ii) we present a novel framework that is able to cope with the restrictions that arise in the event detection of streaming urban data, requiring labels from carefully selected instances.
Enhancing client-agency relationship quality in the advertising industry – an application of project management

Purpose This paper aims to determine the dimensions of service quality of advertising agencies and their effects on relationship quality between an advertising agency and their clients through the social and economic exchange. Design/methodology/approach The intention was to target firms which use the services of an advertising or marketing solutions agency; hence, participants were recruited from a business database service providing details for key decision makers in Australia and New Zealand. An online survey was used in this study. Findings Creative competence, project management processes and project outcome influenced relationship quality through value and interpersonal relationships. However, only creativity had a significant direct relationship with relationship quality. Practical implications Although creativity plays a major role in relationship development, agencies must have efficient and effective project management processes in place to ensure successful project completion within timeline and budget to be able to maintain ongoing relationships with their clients. Originality/value The research draws upon literature from three key disciplines, service quality, relationship marketing and project management, to address the gaps in the current literature related to customer relationship management in the B2B client–agency context.
A Big Data Virtualization Role in Agriculture: A Comprehensive Review

Big data is a collection of large volumes of data sets which are more complicated to analyze using standard data processing methods. It also emphasizes parameters like data variety and velocity data. Big data will play a most significant role in our daily life regarding applications like healthcare electronic commerce, agriculture, telecommunication, government, and financial trading. In the agriculture domain, big data is an optimal method to increase the productivity of farming by gathering and processing information like plant growth, farmland monitoring, greenhouse gases monitoring, climate change, soil monitoring and so forth. Virtualization is an emerging technique that can be combined with big data in agriculture. Virtualization has been used extensively in research for a long time, the term “virtual” entities affecting a real-life form. In agriculture, it has many more physical objects, sensors, and devices. This physical object is virtualized and has digital representation to store, communicate and process via the internet. The information from the virtual object has a large volume of data which helps meaningful data analysis or aspects to make application services like decision making, problem notification, and information handling. This paper provides a comprehensive review of big data virtualization in the agriculture domain. The virtualization methodology, and tools used by many researchers is surveyed.
Blocked Ras Activation in Anergic CD4+ T Cells

T cell anergy is a state of functional unresponsiveness characterized by the inability to produce interleukin-2 (IL-2) upon T cell receptor stimulation. The mitogen-activated protein kinases ERK-1 and ERK-2 and the guanosine triphosphate-binding protein p21Ras were found to remain unactivated upon stimulation of anergic murine T helper cell 1 clones. The inability to activate the Ras pathway did not result from a defect in association among Shc, Grb-2, and murine Son of Sevenless, nor from a defect in their tyrosine phosphorylation. This block in Ras activation may lead to defective transactivation at activator protein 1 sites in anergic cells and may enable T cells to shut down IL-2 production selectively during anergy.
Printed S-Band 4  $\times$ 4 Nolen Matrix for Multiple Beam Antenna Applications

A Nolen matrix design method is proposed as an asymptotic singular case of a recent Blass matrix design algorithm. The procedure is illustrated by a 4 x 4 Nolen matrix, which design is centred at 2.2 GHz, with the amplitude and phase output excitation laws of a Butler matrix using 90deg hybrids. Simulation and measurement results are presented in this paper.
LSH-RANSAC: Incremental Matching of Large-Size Maps

This paper presents a novel approach for robot localization using landmark maps. With recent progress in SLAM researches, it has become crucial for a robot to obtain and use large-size maps that are incrementally built by other mapper robots. Our localization approach successfully works with such incremental and large-size maps. In literature, RANSAC map-matching has been a promising approach for large-size maps. We extend the RANSAC map-matching so as to deal with incremental maps. We combine the incremental RANSAC with an incremental LSH database and develop a hybrid of the position-based and the appearance-based approaches. A series of experiments using radish dataset show promising results.
A key escrow scheme to IOT based on Shamir

The Internet of Things in this article is formed of security center, key escrow centers, readers and tags. Authentication use asymmetric encryption algorithm, there is a private key in the reader / tag. When the reader / tag in some special cases, it may be lost or damaged their own private key and can't be authenticated, then the key recovery is very important. This article compares the two threshold scheme, eventually propose a key escrow program based on the Shamir threshold. Using a the shamir threshold algorithm, the private key of the reader / tag is divided into n parts and sent to key escrow centers. if you want to restore the private key, you need at least t parts. This scheme makes key management more secure and flexible.