Miracle-dz/UniFAR-FTUs huggingface dataset:
Original Article Brain Metastases from Breast Cancer: Identification of a High-risk Group

Aims: Brain metastases from breast cancer are an uncommon initial presentation of metastatic breast cancer, but brain metastases commonly occur later in women’s metastatic illness. The aims of this study were to document the type, frequency, and temporal occurrence of brain metastases from breast cancer as well as the survival of women with such metastases, and to attempt to identify a subgroup of women at high risk of brain metastases who may benefit from pre-emptive medical intervention. Materials and methods: The radiological reports of all women presenting with metastases aged under 70 years who had subsequently died were examined. The type, frequency, temporal occurrence and survival with brain metastases were documented. Correlations were sought between the frequency of brain metastases and age at metastatic presentation, tumour grade, histological type and oestrogen receptor (ER) status. Results: Of 219 patients who had died with metastatic disease and who were under 70 years of age at metastatic presentation, 49 (22%) developed brain metastases. The development of brain metastases was related to young age (P ¼ 0:0002), with 43% of women under 40 years developing brain metastases. Brain metastases were more common in women whose tumours were ER negative (38%) compared with women with ER-positive disease (14%) (P ¼ 0:0003). By combining age and ER status, it is possible to identify a group of women (age under 50 years and ER negative) with a 53% risk of developing brain metastases. This group included many women who had chemotherapy for visceral metastases, and 68% had either stable disease or disease response at other sites at the time of brain metastases presentation. Conclusion: It is possible to identify a subgroup of women with metastatic breast cancer at high risk of brain metastases who may benefit from pre-emptive medical intervention, such as screening or prophylactic treatment. Evans, A. J. et al. (2004). Clinical Oncology 16, 345e349
The utility of ThinPrep cytology and immunohistochemical staining of p16INK4a, Ki-67, and p63 in the assessment of cervical intraepithelial neoplasia (dysplasia)

Background Cervical intraepithelial neoplasia (CIN) is a precancerous lesion with the capability of progressing to squamous-cell carcinoma (SCC). Despite the clearly defined criteria, histopathological diagnoses in hematoxylin and eosin-stained sections are subject to high rates of interpathologist discordance. The aim of this study was to compare and evaluate the results of both ThinPrep cytology and the immunohistochemical-staining pattern of p16, Ki-67, and p63, in diagnosing and grading cervical dysplasia. After such a comparison, the researchers hoped that the diagnostic accuracy in equivocal cases would improve. Patients and methods The current study was carried out on 38 patients with nondysplastic and neoplastic cervical lesions, and initial screening with ThinPrep cytology was performed. Immunohistochemical-staining of p16, Ki-67, and p63 was performed for all the patients. The results were compared with the histopathological diagnoses. Results ThinPrep cytology was found to have 100% sensitivity in detecting low-grade and high-grade squamous intraepithelial lesions – with relatively low specificity – when compared with confirmed histopathological results. Diffuse, strong, band-like p16-immunostaining was detected in 71.4% of the CIN2 patients, 91.7% of the CIN3 patients, and 87.5% of the SCC patients, which were significantly associated with the CIN grade (P<0.001). Most of the CIN3 and SCC patients showed strong Ki-67 and p63 expression levels, with significant CIN-grade association (P<0.001 for both). A significant positive correlation was found between the expression levels of the three biomarkers. Conclusion ThinPrep cytology, with slightly high sensitivity but low specificity, can be useful as a screening method to detect CIN and SCC in patients. Also, p16 and Ki-67 are valuable diagnostic markers for cervical lesions, and the expression levels of p16, Ki-67, and p63 increase as the cervical-lesion grade is higher. Combined staining of these three studied biomarkers is thus useful for detecting and grading CIN, especially in problematical patients, for optimum management.
Stock Price Prediction Using Deep Learning

: Short-term price movements are highly volatile and unpredictable in nature and they challenge investor capital utility in the securities market. Accurately predicting the price variations in stock market has a extensive economic advantage. This can be achieved by fundamental analysis, which involves the study of company performance based on reports published in the public domain. However fundamental data is published once every quarter making short term decision making impossible. Another method, which is undergoing a lot of research work, is to create a predictive algorithmic model using machine learning. This method utilizes the technical analysis as a basis for decision making where Deep Neural Networks are utilized to develop a short-term prediction model. The paper discusses the features and methods that can be utilised in implementing Feed Forward Neural Networks and Recurrent Neural Networks. In future the various approaches could be enhanced to achieve higher levels of accuracy and profitability.
Monitoring and Evaluating Hospital Autonomization and Its Effects on Priority Health Services September 2004 Prepared by :

v Abstract Granting autonomy to public hospitals is expected to improve performance as managers can make decisions on behalf of their hospitals. It is also argued that autonomy frees up resources that can be directed toward priority health services and provide stronger incentives for hospitals to collect user fee revenues. However, incentives and regulations are required to avoid self-satisfying behavior. Resource mobilization can also be hampered if user fee revenues are offset with hospital-budget cuts, and equity can be negatively affected if hospitals give priority to better-off patients. This paper reviews evidence on these rationales for hospital autonomy and their expected consequences on hospital performance. It finds no evidence on both, but negative effects on access to services by the poor are clearly reported. The paper also proposes a new monitoring and evaluation tool that takes into account the effect of autonomy on the availability of priority services and resource mobilization.
Role Of Carbohydarte In Nutrition Ruminant : A Review

Carbohydrates (CHO) are the major source of energy for rumen microorganism and the single excessively component of a dairy cow’s diet. They represent the major component of net energy for astound of keep and milk production. Those are as important to the ruminant animal as they are to non-ruminants, thus they provide the glucose necessary for the adequate function of cells. However, in the ruminant, ruminal fermentation transforms most of the cell wall polysaccharides and all of the intracellular carbohydrates present in the forage into short-chain volatile fatty acids that are then absorbed by the rumen epithelium. Plant tissues contain about 75% carbohydrates, providing the primary sources of energy for both the rumen organisms and the host animal. The carbohydrates found in plant tissues are primarily polysaccharides, cellulose, hemicellulose, pectin, fructan and starches, with slight amounts of other compounds. Cellulose is the most abundant. However, grains are widely used in diets used in intensive production systems with highly productive animals, providing an appreciable amount of starch for ruminal and intestinal digestion. The purpose of this review is to scrutinize the present science on starch digestion in the ruminant, as well as glucose metabolism in the rumen, post-ruminal absorption of starch and glucose requirements of the ruminant. [S.Masoud Davoudi, MahDi EdalatiNasab, Hamed AminiPour. Role Of Carbohydarte In Nutrition Ruminant: A Review. J Am Sci2013;9(1):305-313]. (ISSN: 1545-1003). http://www.jofamericanscience. org. 46
Social Responsibility of Malaysian Small Businesses: Does It Influence Firm Image?

Business arena has witnessed a growing interest in social responsibility practices of firms worldwide. While large companies have been the major target of such demands, small businesses have also been encouraged to practice social and environmental initiatives due to their significant aggregate impact on society. Nevertheless, studies of social responsibility (SR) have mainly focused on large companies and small businesses have been largely ignored in previous studies, specifically in emerging economies where small businesses play a very critical role in the success and development of their respective nations. Thus, to fill this research gap, the current study seeks to investigate the status of social responsibility practices among a number of Malaysian small and medium-sized enterprises (SMEs) and examine its influence on firm image.
The effect of cobalt and boron on the structural, microstructural, and optoelectronic properties of ZnO nanoparticles

Co/B co-doped ZnO (Zn0.93-xCoxB0.07O, x = 0.00, 0.01, 0.02, 0.03, 0.04, and 0.05) nanoparticles were synthesized by the hydrothermal method to investigate the effect of cobalt and boron on the structural, microstructural, and optoelectronic properties of ZnO nanoparticles. The X-ray diffraction method was used for the structural analysis and single phases were found for all Co/B co-doped ZnO nanoparticles. Scanning Electron Microscope (SEM) technique was used to determine the surface morphology, particle size, and the shapes of the nanoparticles. LThe elemental compositions of the nanoparticles were obtained by electron dispersive spectroscopy (EDS). Hexagonal Wurtzite structure was proved by c/a ratios of the ZnCoBO nanoparticles. The Fourier transform infrared (FTIR) studies were performed and explained. The energy band gaps of the samples were calculated and the effects of dopant elements on optical properties were discussed. The maximum band gap occurred for Zn0.93B0. 07O with a band gap energy of Eg = 3.26 eV. The refractive index was calculated using the energy band gap with five different models. The grain sizes and the band gap energies fluctuated as the doping ratio increased. The results showed that the refractive index strongly depends on the Co concentration nonlinearly. It was found that doping cobalt increased the Urbach energy value of B-doped ZnO nanoparticles. The increase in Eu indicates that the structural disorder and the number of defects in the Zn0.93-xCoxB0.07O structures increased with increasing concentration of Co in the Zn0.93-xCoxB0.07O structures. The highest value of Urbach energy was approximately found in the range of 1259 and 1469 meV for 3% Co. Moreover, for 3% Co the concentration-dependent microstrain (Ɛ) values also reached the maximum, dislocation density δ had also the maximum value.
PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY OF SEED EXTRACTS AGAINST PATHOGENIC METHICILLIN RESISTANT

The study was aimed to determine the phytochemical constituents and antibacterial activity of Garcinia kola seeds extracts against pathogenic Methicillin Resistant Staphylococcus aureus (MRSA). Total of 54 Staphylococcus aureus isolates from infected wound and urine were collec from Abubakar Imam Urology Center in Kano State, Nigeria over a period of seven month (December, 2016 to July, 2017), out of which 5 methicillin resistant isolates were found and tested against the extracts. Phytochemical screening of the seeds extract Alkaloid, Tannin, Saponin, and Cardiac glycoside, Flavonoid, Terpenoid, Phenols, Anthraquinone and Steroid. However, reducing sugar is absent. The antibacterial activity of the extracts against the isolates showed that ethanol e 15.25mm) when compared to aqueous extract (14.37mm). The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extracts ranges from 12.5 100mg/ml of the extracts. Statistical analysis of the result showed that there is no significant different on the susceptibility of the organisms against the extracts. Findings from this work support the use of seed extracts from
Involvement of Kinesin 4II and 7I in Chloroplast Motility and Growth in the Moss Physcomitrella patens

3 Acknowledgements.5 Introduction.6 Chloroplast Movement in Cells.6 Physcomitrella patens.7 Kinesins, Microtubules and their Roles in Plants.8 RNA Interference and Inducible Gene Expression.11 Purpose of Study.12 Methods.13 Moss Culture.13 Growth Assay.14 Moss Slide Prep for Microscopy . 16 Chloroplast Avoidance Assay.17 Results.19 Reduction of Kinesin 4-IIb or 7-Ib Results in a Growth Phenotype.19 Quantification of the Kinesin-RNAi Induced Growth Phenotype.22 Kinesin 4-IIb is Necessary for Chloroplast Avoidance.24 Visualization of Microtubules during the Chloroplast Avoidance Response.27 Discussion.30 Bibliography . 35 Appendix . 38
A Decision Tree based Algorithm for Forecasting the Proposed Service Acceptance by Store Customers

: Organizations are under intense pressure today to respond quickly to changing circumstances and innovation since business environment is increasingly becoming complex and changing. Furthermore, data analysis and data mining will create a competitive advantage. Hence, customer relationship management has been very much considered in recent years. Accordingly, in order to understand the effective criteria for accepting the proposed service to customers through the database, the present study aimed to classify the information about the store customers and extract the appropriate pattern using the decision tree algorithm so that it will be possible to properly predict the accepting the proposed service and ultimately, meet the advertising and marketing requirements for the society. According to the results obtained from implementing the proposed system on the collected store data, evaluated during 2016-2018 through the Clementine 12.0 software, the system accuracy level is at a desirable level. ---------------------------------------------------------------------------------------------------------------------------------------
Survey Paper On URL Based Phishing Detection

: It is a Desktop Application for Teachers and Students for the Computer Department which helps us again Phishing attackers that can damage,haram or destroy any computer with just a single click.In this paper Exisiting we propose a heuristic-ased phishing detection technique that uses uniform resource locator (URL) features. We identified features that phishing site URL contain.The proposed method employs those features for phishing detection. The Technique was evaluated with a dataset of 3,000 phising site URLs and 3,000 legitimate site URLs. The result demonstrates that the proposed technique can detect more than 98.23% of phsing sites.
Effects of Telllperature

Mycoplasma bovis, along with other species, is responsible for a number of disease syndromes in cattle which impact both the dairy and beef industries. An outbreak of mycoplasma mastitis in conjunction with a number of positive environmental samples from the farm initiated a study of the survival of mycoplasma organisms in recycled bedding sand. A pile of bedding sand was obtained from the affected dairy and brought to Utah State University, where it was stored outside. The pile was cultured for mycoplasmas and mastitis pathogens on a weekly basis for four months, and then sampled every two to four weeks for another four months. In addition, samples of the sand were subjected to controlled experiments in the laboratory involving temperature, humidity, and chemical disinfection. The results indicate that M. bovis can remain viable and detectable by culture in recycled bedding sand for eight months at the ambient temperatures found in Logan, Utah. The optimal temperature for survival is between 39°F (4°C) and 64°F (18°C). The numbers of M. bovis organisms (measured as colony forming units) in the sand increased at different times during the study, indicating replication. M. bovis reproduced in bedding sand at ambient maximum temperatures between 59°F and 68°F (15°C and 20°C). In the controlled experiment, mycoplasmas reproduced in the bedding sand at 97°F (36°C) when the sand was kept damp, but were not cultivable when it was allowed to dry out. Both 2% chlorhexidine and 0.5% hypochlorite were capable of disinfecting the bedding sand.
Fmfc: Fuzzy Based Improved Mutual Friend Crawling Varnica

: Online Social networks are becoming an important part of research in every field. Crawling such networks and extracting data from them is a very difficult task. Till date, many crawling techniques have been designed for this purpose. The properties of complex networks have been reviewed in this paper. This paper has focused on mutual friend crawling and applied it on a dataset. The proposed technique makes the use of fuzzy logic and a comparison has been made between the existing and proposed technique. The effectiveness of the proposed technique is evaluated using different parameters. This paper also includes a survey of the existing methodologies designed and implemented by different authors. It also provides future directions in this area of research.
Optimization of Cache Size with Cache Replacement Policy for effective System Performance

: The exponential growth of information in the internet over the last decade forces the researchers to think alternate solutions to provide better user service, reduce network bandwidth and reduced user perceived latency. Web Cache is the most promising technique for improving the web performance. Cache replacement is one of the important attributes to be addressed for better results. This paper proposes traditional cache replacement polices LRU, LFU and RR and examines its effectiveness in conjunction with different Cache Size. The results shows that LRU is most promising than other two methods in terms of HR , BHR and LSR and cache Size is definitely influence the effectiveness of the Cache Replacement Algorithms.
A Prospective Study toDetermine Preoperative and Intra Operative Factors Requiring Conversion of Laparoscopic Cholecystectomyto Open Cholecystectomy

Objectives-To determine the pre operative factors based on clinical,laboratory and radiological parameters which leads to conversion of laparoscopic cholecystectomy to opencholecystectomy.To determine intra operative factors based on laparoscopic findings that leads to conversion of laparoscopic cholecystectomy to open cholecystectomy. Aims-To identify difficult dissection by clinical, laboratory and radiological parameters in laparoscopic cholecystectomy. MethodologyAll patients undergoing consecutive cholecystectomy were included in this study. Patients meeting the exclusion criteria were not included in the study. Clinical, laboratory and radiological parameters were analysed for significant correlation with the outcome of the surgery to predict difficult dissection during cholecystectomy. Conclusion-Difficult dissection in cholecystectomy can be predicted using pre-operative parameters. Keywords-GB-Gallbladder,CBD-Commonbile duct,EHC-Enterohepaticcirculation,BMI-Body massindex, LFT-Liver function test -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 26-05-2019 Date of acceptance: 11-06-2019 -------------------------------------------------------------------------------------------------------------------------------------
Study of 40GHz Active Harmonic Mode-locked Erbium-doped Fiber Lasers

The demand for the ultrahigh-speed and ultralarge-capacity optical fiber transmission systems is becoming larger and larger in recent years. Therefore, a stable optical short pulse source with high repletion rate, high SMSR, and high output power pulse train plays as an important role. As mentioned above, they can be achieved by active harmonic mode-locked erbium-doped fiber lasers. In this study, a 40GHz active harmonic mode-locked erbium-doped fiber laser is demonstrated. The fiber cavity consists of all polarization maintain fiber. The pulsewidth 7.81ps and 3.31ps respectively operated at 20GHz and 40GHz was obtained. The average output power is about 1mW and the super-mode suppression ratio (SMSR) is above 50dB. In the simulation section, the simulation results are all close to the experimental results. Active mode-locked fiber ring lasers can be successfully simulated by using VPI.
Electroacupuncture Alleviates Bladder Overactivity via Inhabiting Bladder P2X3 Receptor

Electroacupuncture (EA) has been widely applied for overactive bladder, but the mechanism of its action remains to be clarified. This study was aimed to investigate EA regulating the effect of purinergic signaling in the OAB of rats. Electroacupuncture (continuous wave, 30 Hz, 1 mA) was applied to stimulate the Ciliao point (BL32) and the Huiyang point (BL35) of rats. Results showed that when the P2X3 receptor in bladder peripheral level and the spinal cord central level was involved in the bladder micturition reflex of the afferent signaling, intravenous administration P2X3 antagonist AF-353 can significantly inhibit urination in naive rats and OAB of rats and increase bladder volume and micturition pressure. EA stimulation alleviated bladder overactivity significantly and after the P2X3 receptor was blocked, the EA effect was weakened. EA stimulation can effectively reduce the P2X3 mRNA and protein expression in OAB of rats, spinal cord (L6-S1), and DRG (L6-S1) and can significantly reduce the number of positive P2X3 cells in OAB of rats, spinal cord (L6-S1), and DRG (L6-S1). These findings suggest that EA stimulation could alleviate bladder overactivity, and the function is closely related to the inhabited P2X3 receptor in the bladder.
Chimera of Heat-labile Enterotoxin B chain conjugate with LipL32 and or LipL21 proteins induces strong reactive antibodies in experimental mice

Current killed vaccines against Leptospira lack long-term protective ability and are mostly serovarspecific. Hence, there is an urgent need for a vaccine that can provide long-term and broad protection against the many existing Leptospiraserovars. LipL32 and LipL21 are important conserved lipoproteins among pathogenic Leptospira. As a precedent to vaccine development, we amplified and cloned LipL32, LipL21 and heat-labile enterotoxin B subunit (LTB) genes in E. coli by using the Gateway cloning system, followed by recombinant protein expression. The recombinant LipL21 and LipL32 proteins were then chemically conjugated to LTB. Mice were immunized with the LTB-conjugated LipL32 or LipL21 and the antibody responses against the corresponding proteins were compared with those from mice injected with LipL32 or LipL21 alone or mixed with Sigma Adjuvant. LTB-conjugated LipL32 or LipL21 induced strongly reactive antibodies as compared to the recombinant proteins alone or mixed with Sigma Adjuvant. These results indicated that LTB-conjugated LipL32 and LipL21 could serve as subunit vaccines capable of inducing strong protective immunity in humans and animals against a wide array of Leptospira infection.