Miracle-dz/UniFAR-FTUs huggingface dataset:
Algorithms for Korringa-Kohn-Rostoker electronic structure calculations in any Bravais lattice

We present some algorithms for improvements of band theory calculations based on the Korringa-Kohn-Rostoker method and on the coherent potential approximation, in the cases of ordered metals and random alloys. The purpose of our work was to develop a code flexible enough to deal on equal footing with any lattice geometry. The algorithms proposed are designed to achieve an arbitrary accuracy and to minimize the required computational efforts. In particular, we describe (i) an efficient and accurate method for the calculation of the KKR structure constants, and (ii) an adaptive method for the Brillouin zone integration. These algorithms have been tested for a free-electron Green{close_quote}s function and by explicit calculations for a number of systems and, when possible, discussed in comparison with other methods. {ital Ab initio} calculations for hexagonal close packed and face centered cubic Ti and for Cu{sub 0.75}-Pt{sub 0.25} random alloys are presented. {copyright} {ital 1997} {ital The American Physical Society}
Información colocacional y recuperación de la información

Este proyecto tiene como objetivo investigar la significacion de la informacion colocacional en Recuperacion de la informacion (RI). Una colocacion es una relacion entre dos unidades lexicas (UL) L1 y L2 tal que para expresar un significado especifico en relacion con L1 la eleccion de L2 no es libre (Mel' uk 1995). Asi, para expresar el sentido 'hacer lo que esta previsto que se debe hacer' en relacion con la UL CARGO, podemos decir desempenar un cargo. El mismo sentido predicado de PROMESA se expresaria por CUMPLIR y en combinacion con SECRETO, por GUARDAR. El peso semantico de L1 y L2 no esta equilibrado: mientras L1 (la base de la colocacion) guarda el sentido que tiene cuando no esta en colocacion, el significado de L2 (el colocativo) esta reducido o modificado cuando aparece en colocacion Las siguientes propiedades de las colocaciones las hacen interesantes para RI: 1) A la hora de indexar un texto, los elementos de una colocacion no pueden ser considerados como terminos aislados: es evidente que la aportacion de ABANDONAR en abandono al nino, donde la UL es usada libremente, no es la misma que la aportada en la colocacion abandono el cargo; 2) Una base dada puede formar varias colocaciones con el mismo significado. Asi, el nombre CARGO no solo selecciona ABANDONAR, sino tambien RENUNCIAR, DIMITIR (de) o CESAR (en). 3) Las colocaciones pueden der clasificadas segun una tipologia semanticamente motivada. Nuestra hipotesis es que estas propiedades deben tener ciertos efectos en los resultados de la RI. A pesar de que en los ultimos anos se registra una fuerte tendencia a utilizar informacion linguistica para RI, no se han explorado hasta ahora las colocaciones. La razon se debe a que no existia ningun procedimiento fiable de reconocimiento automatico de colocaciones en los documentos. Sin embargo, algunos trabajos previos basados en la tipologia de las funciones lexicas (FL) (Wanner y Alonso 2001 y Wanner en preparacion) han mostrado la posibilidad de identificar automaticamente colocaciones verbo-nombre. Actualmente hemos extendido el mismo enfoque para reconocer colocacaciones nombre-adjetivo y verbo-adverbio. En nuestra investigacion sobre RI, usamos esta estrategia para la identificacion de colocaciones tanto en los documentos como en las consultas de los usuarios y pretendemos usar la informacion colocacional para mejorar los resultados de RI.
Letter to the Editor: Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels: are dromedary camels a reservoir for MERS-CoV?

To the Editor: In a recent issue of Eurosurveillance, we read the article by Nowotny et al. [1]. In this article, the authors concluded, based on phylogenetic analysis and a high Middle East respiratory coronavirus (MERS-CoV) load in nasal swabs of dromedary camels, that local zoonotic transmission of MERS-CoV from camels may be possible through the respiratory route. We would like to thank the authors for their contribution to the knowledge of MERS-CoV. However, we would like to report a few concerns regarding this study from a methodological point of view [1].
Management of meningitis.

Meningitis occurs mostly in previously fit young people and, because it causes significant mortality and morbidity, must be recognised and treated promptly. Overall, the mortality of bacterial meningitis in adults is 25%, with significant sequelae of disease including deafness and cognitive loss.1 In bacterial meningitis, the first step in pathogenesis is colonisation of the nasopharynx, followed by haematogenous spread to other sites including the meninges.2 In viral meningitis, acquisition is mostly faecal-oral, followed by viraemia.
Pharmacokinetic drug interactions involving Ginkgo biloba

Abstract Ginkgo biloba leaf extracts (GLEs) are popular herbal remedies for the treatment of Alzheimer’s dementia, tinnitus, vertigo and peripheral arterial disease. As GLEs are taken regularly by older people who are likely to also use multiple other drugs for the treatment of, e.g. hypertension, diabetes, rheumatism or heart failure, potential herb–drug interactions are of interest. Preclinical studies of high doses/concentrations of GLEs of varying quality and standardization hinted at both an inhibition and induction of metabolic enzymes and transporters. However, in humans, positive in vitro-findings could not be replicated in vivo. At maximum recommended doses of 240 mg/day, a clinically relevant interaction potential of the standardized GLE EGb 761 could not be shown. GLE doses higher than the recommended ones led to a weak induction of the CYP2C19-mediated omeprazole 5-hydroxylation, and a weak inhibition of the CYP3A4-mediated midazolam 1′-hydroxylation, respectively. Also, the regular intake of a poorly characterized GLE at a dose of 360 mg/day slightly increased the bioavailability of talinolol, a substrate of P-glycoprotein and various organic anion-transporting polypeptides. Thus, regarding pharmacokinetic herb–drug interactions, the intake of the standardized GLE, EGb 761, together with synthetic drugs appears to be safe as long as daily doses up to 240 mg are consumed. If this applies to other extracts prepared according to the European Pharmacopoeia remains uncertain. Also, a relevant potential for drug interactions cannot be excluded for poorly standardized GLEs used in many food supplements.
Correlative live-cell and superresolution microscopy reveals cargo transport dynamics at microtubule intersections

Intracellular transport plays an essential role in maintaining the organization of polarized cells. Motor proteins tether and move cargos along microtubules during long-range transport to deliver them to their proper location of function. To reach their destination, cargo-bound motors must overcome barriers to their forward motion such as intersection points between microtubules. The ability to visualize how motors navigate these barriers can give important information about the mechanisms that lead to efficient transport. Here, we first develop an all-optical correlative imaging method based on single-particle tracking and superresolution microscopy to map the transport trajectories of cargos to individual microtubules with high spatiotemporal resolution. We then use this method to study the behavior of lysosomes at microtubule–microtubule intersections. Our results show that the intersection poses a significant hindrance that leads to long pauses in transport only when the separation distance of the intersecting microtubules is smaller than ∼100 nm. However, the obstructions are typically overcome by the motors with high fidelity by either switching to the intersecting microtubule or eventually passing through the intersection. Interestingly, there is a large tendency to maintain the polarity of motion (anterograde or retrograde) after the intersection, suggesting a high degree of regulation of motor activity to maintain transport in a given direction. These results give insights into the effect of the cytoskeletal geometry on cargo transport and have important implications for the mechanisms that cargo-bound motors use to maneuver through the obstructions set up by the complex cytoskeletal network.
A 60 GHz ultra low-power wake-up radio

This work presents an ultra low-power duty-cycled wake-up radio system for high-data-rate, short-range millimeter-wave WPAN applications. The asynchronous duty-cycled wake-up power management method is proposed and optimized to reduce the average power consumption. As the design example, a 60 GHz radio system is discussed, which consists of a 4-path phase-array transceiver, a duty-cycled wake-up receiver and the digital control circuits. Theoretical analyses of the optimum duty-cycle factor towards minimum average power are shown accordingly. Simulation results are given and a 230 µW average power consumption is achieved for the entire radio, which leads to about 4000-hour operation time for a 1.5-V 1000-mAh re-chargeable battery.
Acute hepatitis C virus infection induces anti‐host cell receptor antibodies with virus‐neutralizing properties

Hepatitis C virus (HCV) causes persistent infection in the majority of infected individuals. The mechanisms of persistence and clearance are only partially understood. Antibodies (Abs) against host cell entry receptors have been shown to inhibit HCV infection in cell culture and animal models. In this study, we aimed to investigate whether anti‐receptor Abs are induced during infection in humans in vivo and whether their presence is associated with outcome of infection. We established an enzyme‐linked immunosorbant assay using a recombinant CD81‐claudin‐1 (CLDN1) fusion protein to detect and quantify Abs directed against extracellular epitopes of the HCV CD81‐CLDN1 coreceptor complex. The presence of anti‐receptor Abs was studied in serum of patients from a well‐defined cohort of a single‐source HCV outbreak of pregnant women and several control groups, including uninfected pregnant women, patients with chronic hepatitis B and D virus (HBV/HDV) infection, and healthy individuals. Virus‐neutralizing activity of Abs was determined using recombinant cell culture–derived HCV (HCVcc). Our results demonstrate that HCV‐infected patients have statistically significantly higher anti‐CD81/CLDN1 Ab titers during the early phase of infection than controls. The titers were significantly higher in resolvers compared to persisters. Functional studies using immunoadsorption and HCV cell culture models demonstrate that HCV‐neutralizing anti‐receptor Abs are induced in the early phase of HCV infection, but not in control groups. Conclusion: The virus‐neutralizing properties of these Abs suggest a role for control of viral infection in conjunction with antiviral responses. Characterization of these anti‐receptor Abs opens new avenues to prevent and treat HCV infection. (Hepatology 2015;62:726–736)
The effect of the acute and chronic administration of CP 96,345, a selective neurokinin1 receptor antagonist, on midbrain dopamine neurons in the rat: A single unit, extracellular recording study

In this study, we examined the effect of acute and chronic administration of the selective neurokinin1 receptor antagonist CP 96,345 on the basal activity of spontaneously active dopamine (DA) neurons in the substantia nigra pars compacta (SNC) and the ventral tegmental area (VTA). This was accomplished using the technique of in vivo, extracellular single unit recording in anesthetized rats. The intravenous (i.v.) administration of CP 96,345 (0.01–1.28 mg/kg) did not significantly alter the firing rate of spontaneously active DA neurons in the SNC and VTA areas. The acute administration of 5 or 10 mg/kg, i.p., of CP 96,345 produced a significant decrease in the number of spontaneously active SNC and VTA dopamine cells compared to vehicle‐treated rats.
Self-efficacy and readiness for transition from pediatric to adult care in sickle cell disease

Abstract Background: Theories of self-care management, particularly the development of self-efficacy or confidence in one’s ability to manage health-related goals, tasks, and challenges may provide a useful framework for developing programs to improve transition from pediatric to adult care for youth and young adults with sickle cell disease (SCD). Objective: The aim of this study was to evaluate the hypothesis stating that ratings of self-efficacy is positively associated with self-ratings of transition readiness. Subjects: A total of 113 individuals with SCD aged 14–26 years at two distinct sites of care were recruited for the study. Materials and methods: Participants completed the Transition Intervention Program Readiness for Transition (TIP-RFT) assessment, the Sickle Cell Self-Efficacy Scale and the Sickle Cell Stress –Adolescent scale. Results: In multivariate regression models, self-efficacy was positively associated with scores on the total TIP-RFT and on the Education/Vocation Planning and Independent Living Skills scales. Older age was independently associated with higher scores on the Independent Living Skills scale and higher stress levels were independently associated with lower scores on Education/Vocation Planning scale. Conclusion: The TIP-RFT assessment, along with measures of self-efficacy and stress, appear to be useful measures of overall transition readiness for youth and young adults with SCD. Future studies should evaluate whether self-management skill development and health outcomes are indeed affected by programs to improve readiness for transition from pediatric to adult care.
Memory Deficits Among Alcoholics: Performance on a Selective Reminding Task

ABSTRACT This article compared alcoholics and healthy controls on the Buschke Selective Reminding Task. Alcoholics demonstrated deficits in memory and learning when compared to healthy controls, even when controlling for age. Examination of the alcoholic sample initially showed that age predicted memory deficits; however, age was no longer a significant predictor once the number of years of heavy drinking was entered into the regression equation. Findings suggest a direct link or mechanism of action between alcohol use and memory impairments, above and beyond effects of age or education.
6-DOF object localization by combining monocular vision and robot arm kinematics

A robot needs to localize an unknown object before grasping it. When the robot only has a monocular sensor, how can it get the object pose? In this work, we present a method of localizing the 6-DOF pose of a target object using a robotic arm and a hand-mounted monocular camera. The method includes an object recognition and a localization process. The recognition process uses point features on a surface of the target as a model of the object. The object localization process combines the robotic motion data and image data to calculate the 6-DOF pose of the object. This method can process objects containing textured planes. We verify the method in real tests.
Generalized Sheet Transition Condition (GSTC) for anisotropic metasurfaces

This paper presents Generalized Sheet Transition Condition (GSTC) for analysis of anisotropic metasurfaces. The present GSTC takes into consideration the coupling between transverse field components on metasurfaces. Based on the shape and dimensions for the element of the metasurface, coupling between transverse fields can be obtained. This coupling between transverse field components can be used to control the polarization of transmitted and reflected fields. Using anisotropic metasurfaces as superstrate for a printed antenna would also enable controlling the polarization of the radiated fields. An example of converting linearly polarized bow-tie antenna to circularly polarized antenna by using anisotropic metasurface is presented as verification for the present analysis.
Altered association of transcriptionally active DNA with the nuclear-matrix after heat shock.

PURPOSE Exposure of human cells to heat leads to denaturation and aggregation of proteins. Within the nucleus, it has been suggested that protein aggregation is linked to the selective inhibition by hyperthermia of nucleotide excision repair in transcriptionally active genes. In this study it was investigated in detail whether and how the inhibition of repair of transcriptionally active genes might be related to alterations in their association with the nuclear-matrix. MATERIAL AND METHODS Different protocols for nuclear-matrix isolation (high salt and lithium 3',5'-diiodosalycilate [LIS] extraction of nuclei) were used to compare DNA loop organization and positioning of transcriptionally active genes in both heated and non-heated cells. RESULTS DNaseI digestion of total genomic DNA in Cu2+ -stabilized LIS-extracted nuclei revealed that heat shock perturbed the formation of nuclear-matrix attachment sites. Specific labelling of active genes indicated that the number of nuclear-matrix attachment sites in transcriptionally active DNA was increased due to the heat shock. At the level of individual genes, heat treatment led to stabilization of the 5' matrix attachment site (MAR) in the transcriptionally active adenosine deaminase (ADA) housekeeping gene. Moreover, heat shock resulted in the formation of an additional MAR at the 3' end of the ADA gene. The inactive 754 locus was unassociated, irrespective of a heat shock. CONCLUSIONS The reported changes in chromatin structure might underlie the selective inhibition of repair in transcriptionally active genes and consequently may be mechanistically linked to the sensitization of heated cells to ionizing radiation.
Independent feeding and metabolic actions of orexins in mice.

Orexin-A and orexin-B (OX peptides) are two putative products of a newly discovered secreted protein encoded by a mRNA restricted to neuronal cell bodies of the lateral hypothalamus (LH). Because the activation of the LH can induce changes in energy balance, we wanted to investigate the actions of OX peptides on energy metabolism in mice. We injected male C57BL/6J mice with different doses (1, 3, and 10 nmol) of orexin-A and orexin-B into the third ventricle (i3vt). A single i3vt injection of orexin-A 3 h into the light period slightly stimulated feeding at the lowest dose only over the following 4 h (11 +/- 09 mg/mouse vs 80 +/- 13 mg/mouse, p < 0.05). Orexin-B showed no effects at any dose. We therefore investigated the effects of 3 nmol orexin-A on energy utilization using indirect calorimetry. Single i3vt injection 3 h after light on, or just before dark onset, or in 4-h fasted mice resulted in increases in the metabolic rate. These effects were associated with decreases or increases in the respiratory quotient regarding the time of injection or the underlying metabolic state of the mice. The present findings provide direct evidence that OX peptides are more likely to be involved in the control of energy metabolism than of food intake in mice.
Dual-band antenna pair for MIMO WiFi compact mobile terminals

In this paper a compact dual-band WiFi antenna pair is proposed which is suitable for compact mobile terminals such as smart phones. The proposed antenna pair is wrapped on a 20.8×3.3×2.7 mm3 spacer and is located at the edge of a 122×62 mm2 ground plane. The antenna geometry advantage is that it allows mobile phone manufacturers to accommodate four antenna elements for Multiple-Input Multiple-Output (MIMO) WiFi applications in their products. Apart from antenna characterization, channel capacity of the proposed antennas is also provided.
Insecticide‐treated cattle for tsetse control: the power and the problems

Trypanosomiasis control increasingly involves financial input from livestock owners and their active participation. If control is carried out on smaller scales than in the past, methods such as aerial and ground spraying and sterile insect techniques will have reduced application. There will be increased reliance on trypanocidal drugs, and bait methods of tsetse control – where flies are attracted to point sources and killed. If drug resistance develops, cheap and simple bait methods offer the only means of disease control that might be applied, and paid for, by stockowners themselves. The methods have been effective in some circumstances, but not in others, and it is important to understand the reasons for the successes and the failures. Analysis is presented of the results of two Tanzanian tsetse control campaigns involving the use of insecticide‐treated cattle. Between 1991, &, 1996, following the introduction of widespread dipping in the Kagera Region, trypanosomiasis declined from > 19 000 cases to < 2400 and deaths from > 1000 to 29. On four ranches in the region, tsetse have been almost eliminated and trypanosomiasis prophylaxis is no longer used. Similarly aggressive use of pyrethroids on Mkwaja Ranch in Tanga Region has not had such dramatic effects. Tsetse and trypanosomiasis are still common, despite high levels of prophylaxis and the deployment of ≈ 200 odour‐baited targets. The difference in the results is attributed to a combination of the much smaller area covered by treated animals at Mkwaja, a greater susceptibility to re‐invasion and a more suitable habitat for the flies. A better understanding of the dynamics of the use of insecticide‐treated cattle is needed before we can predict confidently the outcome of particular control operations.
Interleukin-10 fails to modulate low shear stress-induced neointimal hyperplasia.

INTRODUCTION Overexpression of the anti-inflammatory cytokine interleukin-10 (IL-10) blocks atherosclerotic events in vivo, and IL-10 has been recently hailed as an "immunologic scalpel" for atherosclerosis. Alternatively, mice lacking IL-10 receiving atherogenic diets have increased occlusive lesions. It remains unclear whether such IL-10 modulation broadly applies to other forms of occlusive arterial remodeling. We hypothesized that lack of IL-10 would exacerbate, and exogenous or overexpression of IL-10 would abrogate low shear stress-induced neointimal hyperplasia (NIH). METHODS Wild-type (WT) and IL-10-deficient (IL-10-/-) mice underwent unilateral common carotid artery (CCA) ligation. Low shear stress in the patent ligated artery results in remodeling and formation of neointima containing BrdU and SMC alpha-actin-positive cells. Additional groups of WT mice underwent CCA ligation and were treated daily with intraperitoneal saline or 1 microg of human IL-10. Chronic delivery gene therapy approaches were also utilized to define the role of IL-10 signaling. WT mice were treated adventitially with 1 x 10(10) adenovirus/green fluorescent protein (Ad/gfp) and an Ad/empty control to confirm the veracity of adventitial delivery. Then, Ad viral IL-10 (vIL-10), Ad/empty, and virus buffer alone were applied directly to the adventitia of the CAA immediately following ligation. In separate experiments, 1 x 10(10) Ad/empty or Ad/vIL-10 was injected intramuscularly. CCAs were perfusion fixed 28 days postligation, the time at which NIH is near maximum. RESULTS IL-10-/- mice developed identical NIH areas compared to WT controls. Mice receiving IL-10 demonstrated NIH equivalent to saline controls. Mice receiving intramuscular or adventitial Ad/IL-10 developed high serum levels of IL-10 yet formed NIH areas similar to those of controls. Serum IL-10 levels were significantly higher (P = 0.04) with adventitial delivery. Mice treated adventitially with Ad/gfp showed reliable transfection of cells within the adventitia of CAA. No antibody to human IL-10 was found in the sera of intraperitoneal IL-10-treated mice, which failed to attenuate NIH. CONCLUSION Under the conditions of this experiment, lack of IL-10 does not exacerbate low shear stress-induced NIH, nor does exogenous administration or overexpression of IL-10 attenuate it. Despite high serum levels of vIL-10 in mice treated with ad/vIL-10 adventitially, there appears to be no therapeutic effect despite the confirmed transfection of adventitial cells. Discrepancies between these findings and previous research may be related to IL-10 dosing, inflammation induced by the adenoviral vector, or disparities between the NIH models.