Miracle-dz/UniFAR-FTUs huggingface dataset:
Retention priorities for the intergenerational nurse workforce.

TOPIC Retention of senior, Gen-X, and Millennial nurses is influenced by manager interactions and efforts to create a satisfying work experience. PURPOSE The purpose of this project was a generational assessment of job satisfaction, work environment, and desired characteristics of managers in an effort to improve nurse retention. SAMPLE AND METHODS Data from staff nurses at 22 southern hospitals collected by online survey included measures of job satisfaction and perceptions of safety, the Nurse Manager Desired Traits survey, and the Nursing Work Index-Revised. FINDINGS The satisfaction with work environment scores for the whole group (n = 1,773) were high. Subscale scores showed highest satisfaction with nurse/physician relationships; lowest was nurse control of practice. A specific satisfaction question showed the younger nurses were less satisfied than those over age 40. Nurse safety concerns were expressed by 40% of the sample. One third of Millennial nurses plan to leave their job within the next 2 years. Over two thirds plan to be gone within the next 5 years. Especially alarming is the fact that 61% of the nurse group stated they plan to leave their current jobs within 10 years. RECOMMENDATIONS (a) Create model managers; (b) empower staff nurse councils; (c) stabilize staffing; (d) revamp incentives; and (e) focus on safety.
Individualized protein fortification of human milk for preterm infants: comparison of ultrafiltrated human milk protein and a bovine whey fortifier.

BACKGROUND To improve the nutritional management of pre-term infants, a new individualized human milk fortification system based on presupplementation milk protein analyses was evaluated. METHODS In an open, prospective, randomized multicenter study, 32 healthy preterm infants (birth weights, 920-1750 g) were enrolled at a mean of 21 days of age (range, 9-36 days) when tolerating exclusive enteral feedings of 150 ml/kg per day. All infants were fed human milk and were randomly allocated to fortification with a bovine whey protein fortifier (n = 16) or ultrafiltrated human milk protein (n = 16). All human milk was analyzed for protein content before fortification with the goal of a daily protein intake of 3.5 g/kg. During the study period (mean, 24 days) daily aliquots of the fortified milk were obtained for subsequent analyses of the protein content. RESULTS Both fortifiers were well tolerated, and growth gain in weight, length, and head circumference, as well as final preprandial concentrations of serum urea, transthyretin, transferrin, and albumin were similar in both groups. The ultimate estimated protein intake was equivalent in both groups (mean 3.1+/-0.1 g/kg per day). Serum amino acid profiles were similar in both feeding groups, except for threonine (significantly higher in the bovine fortifier group) and proline and ornithine (significantly higher in the human milk protein group). CONCLUSIONS Protein analyses of the milk before individual fortification provides a new tool for an individualized feeding system of the preterm infant. The bovine whey protein fortifier attained biochemical and growth results similar to those found in infants fed human milk protein exclusively with the corresponding protein intakes.
Evaluation of nine teat dip formulations under experimental challenge to staphylococcus aureus and streptococcus agalactiae.

Nine postmilking teat dips were evaluated by an experimental challenge model against either Staphylococcus aureus, Streptococcus agalactiae, or both. Formulations containing . 9 and . 6% sodium hypochlorite, 1% sodium dichloro-s-triazene-trione, . 55% chlorhexidine gluconate, and . 35% povidone iodine reduced incidence of Staphylococcus aureus infections 56.8, 28.3, 75.9, 92.5, and 77.9%. Incidence of infections with Streptococcus agalactiae was reduced 48.1 and 63.2% by 1.7 and 1% sodium dichloro-s-triazene-trione formulations. The 1% chlorhexidine gluconate and . 35% povidone iodine products reduced Streptococcus agalactiae infections 71.0 and 67.0%. Three experimental 1% iodophor formulations reduced Streptococcus agalactiae infections 28.9, 44.8, and 50.7%. The experimental challenge model was refined further and provided an efficient method to determine efficacy of postmilking teat dips.
Experiências vivenciadas por adolescentes em tribos urbanas: com a palavra os emos

Este trabalho tem como objetivo investigar a insercao de adolescentes na tribo urbana emo , assim como as repercussoes no seu desenvolvimento e em suas relacoes familiares. Com este intuito, foi realizada uma pesquisa participativa com adolescentes que se autodenominam como emos e seus familiares. Como estrategias metodologicas, foram realizadas entrevistas semi-estruturadas, observacao e analise de fotografias selecionadas pelos participantes. A partir dos dados apresentados, foi possivel verificar que o ingresso dos adolescentes e motivado pela identificacao com o estilo musical e caracterizacao visual do grupo, sendo muitas vezes mediada por amigos. Nas relacoes familiares, cabe destacar que o impacto provocado pelo ingresso no grupo depende de caracteristicas previas dessas familias, sendo que o dialogo e o respeito contribuem como um fator de protecao para esses adolescentes. O ambiente virtual e o principal contexto de interacao entre os membros do grupo, ja que este propicia uma relacao entre iguais, minimizando a estigmatizacao vivenciada pelos emos em outros espacos. De fato, grande parte dos entrevistados ressalta ter sido alvo de violencia e discriminacao em funcao da sua participacao no grupo, principalmente no ambiente escolar. Esta violencia, agregada a comportamentos de risco como a automutilacao e isolamento, fazem com que a participacao dos adolescentes nessas tribos se caracterize como uma situacao de vulnerabilidade, sendo necessaria uma maior atencao para o grupo apresentado.
Audio Hashprints: Theory & Application

Author(s): Tsai, Timothy | Advisor(s): Morgan, Nelson | Abstract: We rely heavily on search engines like Google to navigate millions of webpages, but a lot of content of interest is multimedia, not text data. One important class of multimedia data is audio. How can we search a database of audio data? One of the main challenges in audio search and retrieval is to determine a mapping from a continuous time-series signal to a sequence of discrete symbols that are suitable for reverse-indexing and efficient pairwise comparison. This talk introduces a method for learning this mapping in an unsupervised, highly adaptive way, resulting in a representation which we call audio hashprints. We will discuss the theoretical underpinnings that determine how useful a particular representation is in a retrieval context, and we show how hashprints are a suitable representation for tasks requiring high adaptivity. We investigate the performance of the proposed hashprints on two different audio search tasks: synchronizing consumer recordings of the same live event using audio correspondences, and identifying a song at a live concert. Using audio hashprints, we demonstrate state-of-the-art performance on both tasks.
Domain switching between hrpR and hrpS affects the regulatory function of the hybrid genes in Pseudomonas syringae pv. phaseolicola.

Abstract In prokaryotes, a diverse set of physiological processes is regulated by transcription factors which belong to the well-conserved, enhancer-binding protein (EBP) family. These regulatory proteins function together with the alternate sigma factor (sigma(54)). Structurally, the EBPs are characterized by a central activator domain, containing the recognition motif for the RNA polymerase/sigma(54) complex (Esigma(54)), and the C-terminal domain, containing a DNA-binding helix-turn-helix motif. A regulatory system of the EBP type also exists in Pseudomonas syringae, where it controls the expression of genes required for the induction of disease symptoms and resistance responses in plants. The system consists of the two genes, hrpR and hrpS, which belong to the hrp (hypersensitive response and pathogenicity) gene cluster. The two genes show a high degree of structural and sequence similarities, but function at different positions in the hrp regulatory cascade of the bean pathogen Pseudomonas syringae pv. phaseolicola. In this paper, we were interested in the basis of the difference in specificity between hrpR and hrpS. The functional specificities of the two domains of hrpS and hrpR were analysed by domain switching. Complementation analyses with the hybrid genes and retardation experiments with the protein products showed significant differences between the respective domains of hrpS and hrpR.
Survival of profoundly disabled people with severe mental retardation.

OBJECTIVE To define further the association between survival and clinical disabilities in profoundly disabled people with mental retardation in an 11-year period. RESEARCH DESIGN An 11-year follow-up study of the survival of six mutually exclusive subgroups. The presence of severe, profound, or suspected mental retardation and incontinence were considered in all individuals when forming the subgroups. Varying combinations of abilities in mobility, rolling, feeding, and arm-hand use were also considered. PARTICIPANTS Six subgroups of severely disabled subjects. Included were 128,248 of 155,851 persons who received services from the California Department of Developmental Services between January 1980 and March 1991. MEASUREMENTS/MAIN RESULTS Survival estimates for individuals who were immobile and could not roll over were short regardless of arm-hand use or feeding status, as were estimates for people who were tube fed. For individuals who could roll over, but were otherwise immobile, survival was relatively improved. CONCLUSION Individuals who are unable to move their extremities or bodies voluntarily or who require tube feeding have very shortened life expectancies.
An Approach to Improve Physical Activity by Generating Individual Implementation Intentions

Daily physical activity not only empowers the body, but it also invigorates the mind and helps people cope with the struggle of everyday life. A balanced amount of moderate to vigorous physical activity is recommended. Major barriers that lead to low levels of physical activity are lack of time and motivation. The objective of this paper is to generate individual recommendations to improve physical activity by using if-then plans - so called Implementation Intentions. We developed a mobile application named DayActivizer to collect all the necessary activity data by the user. Based on the collected data, the application automatically recommends activities within if-then plans with an increasing degree of physical effort to counteract insufficient physical exercise concerning individual daily routine. To evaluate our approach, we conducted a field study (N=8) and qualitative interviews in which every participant was asked to examine the validity of the individual recommended implementation intentions.
Atypical Antipsychotics in Older Adults

Psychotic symptoms are common in older adults and reflect a variety of psychiatric and medical conditions. Antipsychotic drugs form the core of the treatment of these symptoms; however, treatment of the elderly is complicated by a high frequency of comorbid medical illnesses, risk of side effects, and age‐related changes in pharmacodynamics and pharmacokinetics. The superior safety and efficacy of atypical antipsychotics makes them first‐line agents for managing psychotic patients with schizophrenia. Their uses now extend to other conditions such as schizoaffective disorders, delusional disorder, and mood disorders with psychotic features. Although the drugs have been studied extensively in young subjects, well‐designed, double‐blind, placebo‐controlled studies are relatively lacking in the elderly. Our knowledge of their safety, efficacy and dosage in older adults is based on a few studies with small samples or extrapolated from studies of younger patients. Several psychiatric and medical conditions that are associated with psychotic symptoms in older people are reviewed, as well as how these patients may benefit from treatment with these agents.
The method of double chains for largest families with excluded subposets

For a given finite poset $P$, $La(n,P)$ denotes the largest size of a family $\mathcal{F}$ of subsets of $[n]$ not containing $P$ as a weak subposet. We exactly determine $La(n,P)$ for infinitely many $P$ posets. These posets are built from seven base posets using two operations. For arbitrary posets, an upper bound is given for $La(n,P)$ depending on $|P|$ and the size of the longest chain in $P$. To prove these theorems we introduce a new method, counting the intersections of $\mathcal{F}$ with double chains, rather than chains.
Réponses écophysiologiques et moléculaires des plantes aux stress xénobiotiques complexes de faible intensité : implications dans les capacités de protection environnementale des bandes enherbées

Les pollutions par les xenobiotiques, en particulier les pesticides, et les metaux lourds issus des activites agricoles presentent une grande complexite de composition chimique et de dynamique spatio-temporelle. La presence de bandes enherbees entre les parcelles cultivees et les cours d’eau permet une limitation de la diffusion de ces pollutions residuelles vers les milieux naturels. Le compartiment vegetal de ces bandes enherbees peut jouer de multiples roles dans ce contexte de protection environnementale. L’etude comparative realisee in situ et en conditions controlees de laboratoire a permis de mettre en evidence le role biologique du compartiment vegetal avec son implication directe dans les processus in planta d’absorption, de stockage et/ou de degradation au moins partielle. Un tel role phytoremediateur est dependant de la capacite des plantes a se maintenir sur ces milieux pollues, qui differe selon l’espece consideree et structure ainsi les communautes vegetales des bandes enherbees. L’etude integrative en conditions controlees des reponses des plantes aux interactions avec les xenobiotiques a faibles doses, a differentes echelles de complexite du fonctionnement vegetal, a permis de montrer les effets de ces stress chimiques chez l’espece modele Arabidopsis thaliana et chez l’espece prairiale Lolium perenne. Les xenobiotiques et les metaux lourds a des doses subtoxiques ont induit d’importants bouleversements metabolomiques et moleculaires chez ces especes, avec des effets cryptiques de ces polluants et de leurs produits de degradation. L’analyse en conditions de multi-pollution, qui refletent de maniere realiste les pollutions peri-agricoles, a montre la complexite et la difficulte de prediction des interactions entre les effets des contaminants en melange. Ces mecanismes de reponses different selon l’espece et le polluant et laissent supposer des divergences en termes de perception et/ou de transport des polluants, ou de coordination des reponses moleculaires et metaboliques. Arabidopsis a ainsi presente une coordination de ses reponses orientee vers une augmentation des metabolites de stress, et une diminution des metabolites carbones (sucres solubles), en parallele de modifications de l’expression de genes impliques dans les defenses antioxydantes, les defenses contre les stress xenobiotiques, ou dans la dynamique des phytohormones. Le stress chimique a entraine chez Lolium des modifications majeures du metabolisme azote, ainsi qu’un remaniement des processus de photorespiration. L’analyse transcriptomique de cette espece a de plus montre que la majorite des genes identifies sont impliques dans des voies de transduction de signal, montrant ainsi la complexite des mecanismes de reponse et les couplages qui existent entre les signaux metaboliques, en particulier lies aux sucres, les voies de signalisation associees aux phytohormones, les signaux de stress et la photosynthese.
Stress drops and radiated energies of aftershocks of the 1994 Northridge, California, earthquake

We study stress levels and radiated energy to infer the rupture characteristics and scaling relationships of aftershocks and other southern California earthquakes. We use empirical Green functions to obtain source time functions for 47 of the larger (M ≥ 4.0) aftershocks of the 1994 Northridge, California earthquake (M6.7). We estimate static and dynamic stress drops from the source time functions and compare them to well-calibrated estimates of the radiated energy. Our measurements of radiated energy are relatively low compared to the static stress drops, indicating that the static and dynamic stress drops are of similar magnitude. This is confirmed by our direct estimates of the dynamic stress drops. Combining our results for the Northridge aftershocks with data from other southern California earthquakes appears to show an increase in the ratio of radiated energy to moment, with increasing moment. There is no corresponding increase in the static stress drop. This systematic change in earthquake scaling from smaller to larger (M3 to M7) earthquakes suggests differences in rupture properties that may be attributed to differences of dynamic friction or stress levels on the faults.
Forte incidence à la Réunion d'une mutation homozygote de la lamine responsable d'un phénotype lipodystrophique (Dunnigan) à haut risque d'arythmie ventriculaire maligne : étude rétrospective d'une cohorte de 40 patients

Contexte : Les mutations du gene de la lamine A/C sont responsables d'un large spectre de phenotypes. Le risque de mort subite des laminopathies du muscle strie necessite le recours frequent au defibrillateur automatique implantable (DAI). Dans les laminopathies du tissu adipeux, l'atteinte cardiaque primitive est exceptionnelle. Objectifs : Decrire l'histoire naturelle et les atteintes cardiaques dans la lipodystrophie partielle familiale de Dunnigan (FPLD) liee a une mutation uniquement presente a la Reunion. Methodes : Une etude retrospective a ete conduite sur 40 patients, originaires de l'ile de la Reunion, porteurs de la mutation T655fx49 sur l'exon 11 de LMNA a l'etat heterozygote ou homozygote. Resultats : Des 40 patients appartenant a 24 familles, 28 (70%) etaient heterozygotes et 12 (30%) homozygotes. Chez les homozygotes, le phenotype etait particulierement severe (hypertriglyceridemie, lipoatrophie, diabete precoce) avec une forte prevalence des atteintes cardiaques : cardiomyopathie dilatee (CMD) (p=0.01), troubles conductifs (p=0.0004), arythmies supraventriculaires (p=0.03) et arythmies ventriculaires malignes (AVM) (p=0.01). Cinq patients (13%) ont presente une AVM : 3 ont recu une therapie appropriee du DAI sur tachycardie ventriculaire, et 2 sont morts subitement. La FEVG moyenne de ces 5 patients etait de 41 ± 16 %. En analyse univariee, 4 facteurs predictifs d'AVM ont ete identifies : FEVG 120 ms (p=0.006). Une AVM est survenue uniquement chez des patients avec au moins 2 facteurs de risque. Conclusions : La mutation reunionnaise T655fx49 a l'etat homozygote est responsable d'un phenotype severe de FPLD associe a des atteintes cardiaques frequentes, similaire aux laminopathies des muscles stries. Les 4 facteurs de risque permettront d'identifier les patients a haut risque rythmique et ainsi selectionner au mieux les candidats au DAI.
Catabolic/anabolic balance and muscle wasting in patients with COPD.

BACKGROUND The mechanisms leading to muscle wasting in patients with COPD are still uncertain. This study was undertaken to evaluate the relationships among circulating levels of catabolic factors (ie, interleukin [IL]-6 and cortisol), anabolic factors (ie, bioavailable testosterone [Tbio], dehydroepiandrosterone sulfate [DHEAS], and insulin-like growth factor [IGF]-I), and mid-thigh muscle cross-sectional area (MTCSA) in patients with COPD. METHODS Serum levels of the above factors were measured in 45 men with COPD (mean [+/- SEM] FEV(1), 43 +/- 3% predicted; mean age, 67 +/- 1 years) and 16 sedentary healthy men of similar age. MTCSA was quantified using CT scanning. Patients with COPD were subdivided into two groups according to the MTCSA (< 70 or >or= 70 cm(2)). RESULTS There was a greater prevalence of hypogonadism (ie, Tbio, < 2 nmol/L) in patients with COPD compared to control subjects (22% vs 0%, respectively). Patients with an MTCSA of < 70 cm(2) had significantly reduced levels of DHEAS compared to those in healthy subjects (p < 0.01). IL-6 levels were significantly higher in both subgroups of COPD patients compared to those in control subjects (p < 0.005). The cortisol/DHEAS, IL-6/DHEAS, IL-6/Tbio, and IL-6/IGF-I ratios were significantly greater in COPD patients with an MTCSA of < 70 cm(2) compared to those in control subjects (p < 0.05). The cortisol/DHEAS and IL-6/DHEAS ratios were also significantly greater in COPD patients with an MTCSA of < 70 cm(2) than in COPD patients with an MTCSA of >or= 70 cm(2) (p < 0.05). In a stepwise multiple regression analysis, the IL-6/DHEAS ratio explained 20% of the variance in MTCSA (p < 0.005). CONCLUSION Catabolic/anabolic disturbances were found in COPD patients leading to a shift toward catabolism and possibly to the development of peripheral muscle wasting.
Modeling and solution methods for viable routes in multimodal networks

This study aims to present a shortest viable route selecting model and its algorithm for freight transportation management in multimodal networks. A route is called viable only if its sequence of modes is feasible with respect to a set of constraints. Three characteristics of viable intermodal routes are identified :(1)logical modal sequence;(2) limited transfer times; and (3) transportation economies of scale. A model incorporating the three characteristics into the intermodal routing selection problem is developed. The concepts of generalized cost and penalty factor are employed. Label correcting approach is used to solve the model. An illustrative example is provided. The model can be developed as a tool for decision support.
System Using Tandem Repeats of the cA Peptidoglycan-Binding Domain from Lactococcus lactis for Display of both N- and C-Terminal Fusions on Cell Surfaces of Lactic Acid Bacteria

ABSTRACT Here, we established a system for displaying heterologous protein to the C terminus of the peptidoglycan-binding domain (cA domain) of AcmA (a major autolysin from Lactococcus lactis). Western blot and flow cytometric analyses revealed that the fusion proteins (cA-AmyA) of the cA domain and α-amylase from Streptococcus bovis 148 (AmyA) are efficiently expressed and successfully displayed on the surfaces of L. lactis cells. AmyA was also displayed on the cell surface while retaining its activity. Moreover, with an increase in the number of cA domains, the quantity of cA-AmyA fusion proteins displayed on the cell surface increased. When three repeats of the cA domain were used as an anchor protein, 82% of α-amylase activity was detected on the cells. The raw starch-degrading activity of AmyA was significantly higher when AmyA was fused to the C terminus of the cA domain than when it was fused to the N terminus. In addition, cA-AmyA fusion proteins were successfully displayed on the cell surfaces of Lactobacillus plantarum and Lactobacillus casei.