Miracle-dz/UniFAR-FTUs huggingface dataset:
VREX: Virtual reality education expansion could help to improve the class experience (VREX platform and community for VR based education)

This paper proposed an innovative education platform-VREX (Virtual Reality based Education eXpansion), with combination of online and offline, to improve the curriculum building and teaching experience. VREX is based on Virtual Reality (VR) and we believe VR can revolutionize the education ecosystem. With some trials, we found VR can be used to promote curriculum effectiveness in an immersive environment so that students can have intuitive sense to understand some abstract knowledge, which is always hard for teachers to describe. We have tried to transfer slides into VR scenes, for the students to learn knowledge in a rather real but totally virtual world. The main contributions were made: (1) VREX build an open and immersion virtual O2O classroom with internet and VR devices so that real classrooms might be used in a different way in the future. (2) VREX provides a distributed mode for students to experience an interactive learning process at anytime, anywhere and any-frequency. (3) VREX can be used to support education in different disciplines, from K-12 to Universities, and we provided some practical cases, like ‘Marine Life’ to show creatures in deep sea, which provides immersive experience to makes students feel they were there. Finally, the feasibility and advantage of VREX are proved by the actual statistical data in the 3rd season 2017.
MODELE DE PLUS COURT CHEMIN MULTIOBJECTIF POUR LE TRANSPORT INTERMODAL AU SEIN DE LA CHAINE LOGISTIQUE VERTE

Les impacts du transport sur l'environnement et la societe sont indeniables de nos jours. La mondialisation et les prises de consciences environnementales sans cesse croissantes contraignent les autorites gouvernementales et les entreprises a prendre des mesures pour limiter les impacts de leurs activites sur l'environnement et la societe. Les entreprises de logistiques et de transport ne sont pas en reste dans cette dynamique, et des recherches sont de plus en plus menees pour mieux comprendre et limiter les impacts emanant de leurs activites. Le transport est connu comme etant une activite economique ayant d'enormes impacts sur l'environnement; l'objectif de notre etude est de developper un systeme d'aide a la decision au choix d'un chemin dans un systeme de transport intermodal permettant de reduire ces impacts. Le cout et le temps de transport ne sont donc plus les seuls criteres de choix d'un chemin ; ainsi nous prenons en compte egalement les criteres environnementaux et societaux. Le modele ici presente tente de reproduire les caracteristiques et le comportement d'un systeme de transport intermodal afin de proposer aux decideurs un chemin avec le meilleur rapport impact/cout. Dans cet article, nous presentons le modele multiobjectif servant de base a notre systeme d'aide a la decision.
Immunoreactive proadrenomedullin N-terminal 20 peptide in human tissue, plasma and urine.

Proadrenomedullin N-terminal 20 peptide (PAMP) is a candidate for a novel biologically active peptide processed from proadrenomedullin. This study clearly demonstrates the existence of PAMP in vivo that had been deduced from analysis of cDNA. To identify PAMP in vivo, we established a radioimmunoassay for PAMP and characterized immunoreactivities in human tissue, plasma and urine. Half maximal inhibition of the assay was observed at 10 fmol/tube. A high concentration of immunoreactive PAMP was found in adrenal medulla (18.4 +/- 8.95 fmol/mg, mean +/- S.D.) and pheochromocytoma tissue (12.3 +/- 9.82 fmol/mg) where the concentrations are comparable to that of adrenomedullin. As determined by three different kinds of chromatography, most of the immunoreactive peptide in pheochromocytoma was eluted at a position exactly identical to that of synthetic PAMP. Further, considerable concentration of immunoreactive PAMP was found in human plasma and urine. The present data indicate that PAMP as well as adrenomedullin is processed from an adrenomedullin precursor.
SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation

ABSTRACT Reversible methylation of lysine residues has emerged as a central mechanism for epigenetic regulation and is a component of the “histone code,” which engenders histones with gene regulatory information. KDM4A is a histone demethylase that targets tri- and dimethylation marks on histone H3 lysines 9 and 36. While the abundance of KDM4A oscillates in the cell cycle, little is known how this enzyme is regulated to achieve targeted effects on specific histone residues in chromatin. Here, we report that a previously unstudied SCFFBXO22 ubiquitin ligase complex controls the activity of KDM4A by targeting it for proteasomal turnover. FBXO22 functions as a receptor for KDM4A by recognizing its catalytic JmjN/JmjC domains via its intracellular signal transduction (FIST) domain. Modulation of FBXO22 levels by RNA interference or overexpression leads to increased or decreased levels of KDM4A, respectively. Changes in KDM4A abundance correlate with alterations in histone H3 lysine 9 and 36 methylation levels, and transcription of a KDM4A target gene, ASCL2. Taken together, these results demonstrate that SCFFBXO22 regulates changes in histone H3 marks and cognate transcriptional control pathways by controlling KDM4A levels, and they suggest a potential role for FBXO22 in development, differentiation, and disease through spatial and temporal control of KDM4A activity.
The epidemiology of atherosclerosis and coronary heart disease.

• What are the main risk factors that have been associated with coronary heart disease? • What risk factor has always been found in population groups with epidemic coronary disease? • What is the risk of coronary heart disease in ex-smokers compared to smokers? • What explanation is there for epidemic hypercholesterolemia in a population?
La utilización del diccionario durante las actividades de lectura intensiva

El autor de esta comunicacion esta de acuerdo con Christine Nuttall (1996: 31) en que el fin de un programa de desarrollo de la lectura es «to enable students to enjoy (or at least feel comfortable with) reading in the foreign language, and to read without help unfamiliar authentic texts, at appropriate speed, silently and with adequate understanding». Llamo la atencion sobre el hecho de que Nuttall (1996) incluye en la definicion la expresion «sin ayuda» y lo justifica afirmando que cuando el estudiante esta realizando una actividad de lectura en la vida real (por ejemplo, leer el nombre de un autobus en la parada de autobus) el estudiante no suele disponer del profesor o de su diccionario y a menudo ocurre que dispone de muy poco tiempo para producir su respuesta. Es por ello que Nuttall (1996: 31) establece como uno de los objetivos de un programa de desarrollo de la lectura que el estudiante pueda leer solo. Este rechazo a la utilizacion del diccionario enlaza con una tradicion en la ensenanza de lenguas extranjeras que recomienda no emplear los diccionarios en el aprendizaje de una lengua extranjera, en parte, segun Gairns y Redman (1986: 79), como reaccion al metodo de gramatica-traduccion. A finales de la decada de los 70 muchos profesores de lenguas extranjeras asociaron la utilizacion del diccionario con una cierta actitud negativa del estudiante consistente en, aparentemente, no estar dispuesto a esforzarse por adivinar el sentido de la expresion problematica (Gairns y Redman, ibid). Summers (1988: 112-113) menciona varias justificaciones que los profesores de lengua extranjera dan para no recomendar la utilizacion del diccionario durante las actividades de lectura, en la clase: a) la adiccion (using. slavishly) del alumno al diccionario bilingue, b) los diccionarios interrumpen la concentracion del estudiante, y c) es mejor que el estudiante adivine el sentido mediante la informacion contextual.
Response expectancy as a determinant of experience and behavior.

Response expectancies, defined as ex- pectancies of the occurrence of nonvolitional responses, have generally been ignored in theories of learning. Research on placebos, hypnosis, and fear reduction indicates that response expectancies generate corre- sponding subjective experiences. In many cases, the genuineness of these self-reported effects has been substantiated by corresponding changes in behavior and physiological function. The means by which re- sponse expectancies affect experience, physiology, and behavior are hypothesized to vary as a function of re- sponse mode. The generation of changes in subjective experience by corresponding response expectancies is hypothesized to be a basic psychological mechanism. Physiological effects are accounted for by the mind- body identity assumption that is common to all non- dualist philosophies of psychology. The effects of re- sponse expectancies on volitional behavior are due to the reinforcing properties of many nonvolitional re- sponses. Classical conditioning appears to be one method by which response expectancies are acquired, but response expectancy effects that are inconsistent with a conditioning hypothesis are also documented.
Tolerance to Headache Medications

Tolerance (declining therapeutic response over time) and augmentation (a worsening of symptoms due to ongoing treatment) are commonly seen during treatment for neurological disorders. In Parkinson’s disease, therapy with levodopa is associated with both tolerance and augmentation, and similar examples exist for diseases as varied as restless leg syndrome and insomnia. In migraine, augmentation is often referred to as medication overuse headache, or the paradoxical worsening of headache symptoms due to excessive use of certain analgesics. Tolerance is a far less studied phenomenon in the field, although clinical experience and anecdotal evidence suggest that tolerance to migraine medications is far from uncommon. For preventive medications, tolerance has been reported with pizotifen, flunarizine, and topiramate, among others. For acute medications, it has been reported with ergotamine, triptans, barbiturates and opioids and, at least in animals, with nonsteroidal anti-inflammatory drugs. Since many of these medications can also induce migraine chronification (augmentation), for migraine, the distinction between both concepts is sometimes tenuous. Because the topic is incompletely studied and many of the concepts that are applicable to pain syndromes are also relevant to headache disorders, we have reviewed and commented on 5 recent papers that may add to our knowledge to the topic.
DC Capacitor Voltage Equalization in Neutral Clamped Inverters for DSTATCOM Application

Multilevel neutral point clamped (NPC) inverter systems are increasingly used in load compensation applications. However, the most significant problem associated with these compensators is the capacitor voltage imbalances and drift due to dc components in the zero sequence current, resulting in degradation of tracking performance of the voltage source inverter. This paper proposes a carrier-based pulsewidth modulation control for an inverter-chopper circuit in order to regulate the capacitor voltages to their reference values. To demonstrate the simplicity and effectiveness of the aforementioned control scheme, a three-phase four-wire three-level NPC compensator system is taken as an example. Detailed simulation has been carried out in PSCAD 4.2. 1. Experiments are conducted to validate the proposed control scheme.
Cardiac tissue engineering using stem cells.

The limited clinical success of stem-cell injections for the treatment of myocardial infarction [1], [2] has been mainly attributed to the low retention and survival of injected cells. Alternative methods for improving the efficiency of cell delivery include the following: 1) injection of a mixture of bioactive hydrogels and cells followed by cell-hydrogel polymerization in situ [3] and 2) the epicardial implantation of a tissue-engineered cardiac patch [4]. Although surgically more complex than cell or cell-hydrogel injection, the patch implantation is also expected to yield improved survival of delivered cells, and potentially, a more efficient structural and functional tissue reconstruction at the infarct site.
Systemic complement activation in psoriasis vulgaris

Nineteen patients with psoriasis vulgaris and no other cause for systemic complement activation were studied for evidence of such activation. There was a marked elevation in serum C5b‐9 complexes with no other significant complement abnormalities, and no correlation between C5b‐9 levels and disease activity. This is the most detailed study of complement in psoriasis yet attempted and confirms that complement activation is a feature of psoriasis vulgaris.
Antioxidant potential of tomatoes cultivated in organic and conventional systems

The objective of the study was to compare the effect of organic and conventional cultivation on the antioxidant compound content and antioxidant activity of the Carmen tomato cultivar. Tomatoes were analyzed regarding ascorbic acid, phenolic compounds, lycopene content and antioxidant activity. Organic tomatoes presented higher content of ascorbic acid and total phenolics (641.39 and 4466.66 mg/100 g EAG on dry wt basis) than did the conventional tomatoes (510.16 and 3477.50 mg/100 g EAG on wt dry basis, respectively). There was no difference in lycopene concentrations between the organic and conventional. The ether, alcohol and aqueous extracts obtained from the tomatoes were subjected to the DPPH test and the β-carotene/linoleic acid system assay. The alcohol and aqueous extracts from organic tomatoes presented higher antioxidant activity in the DPPH test (25.43 and 14.28%, respectively) than the conventional tomatoes (19.52 and 11.33%, respectively). Organic tomatoes had higher antioxidant potential probably due to its higher ascorbic acid and total phenolic values.
Rule-based generation of exploded-views and assembly sequences

Abstract Direct planning of assembly sequences is either very complicated computationally, or requires an ‘expert’ user. This paper presents a new approach to the automatic generation of assembly plans which involves two phases. An ‘exploded’ layout of the assembled product is first found from its topological and geometric description by a graph-based procedure. Then, a knowledge-based technique is used for planning of selected assembly sequences by utilizing theoretical as well as heuristic knowledge of mechanical components and assembly processes. Besides serving the assembly planning phase, automatic generation of exploded-views could also be a most desirable feature of any computer-aided design system. An example demonstrates the application of the method to an actual product.
The Open Method of Co-Ordination: A Way to the Europeanization of Social and Employment Policies?

The open method of co-ordination (OMC) can contribute to the co-ordinated modernization of the national systems of employment and social protection in Europe, if it is institutionalized in a relatively stable way at the European level and if the European processes can influence effectively the national reform strategies. The first challenge was met successfully by the bureaucratization, codification and formalization of some co-ordination processes at the European level. These processes can be interpreted as the institutionalization of a social field. The second challenge refers to the need for an effective coupling between the European and the national arenas. Currently, the most important way of coupling these two social fields is based on mutual learning. Given the limitations of such a predominantly cognitive coupling, the Commission can either enforce the ‘national ownership’ of the co-ordination processes, improve the mutual learning processes or strengthen the strategic (‘financial incentives’) and normative (‘legal obligations’) forms of coupling between the European and national social fields.
Evidence for degenerate tetraploidy in bdelloid rotifers

Rotifers of class Bdelloidea have evolved for millions of years apparently without sexual reproduction. We have sequenced 45- to 70-kb regions surrounding the four copies of the hsp82 gene of the bdelloid rotifer Philodina roseola, each of which is on a separate chromosome. The four regions comprise two colinear gene-rich pairs with gene content, order, and orientation conserved within each pair. Only a minority of genes are common to both pairs, also in the same orientation and order, but separated by gene-rich segments present in only one or the other pair. The pattern is consistent with degenerate tetraploidy with numerous segmental deletions, some in one pair of colinear chromosomes and some in the other. Divergence in 1,000-bp windows varies along an alignment of a colinear pair, from zero to as much as 20% in a pattern consistent with gene conversion associated with recombinational repair of DNA double-strand breaks. Although pairs of colinear chromosomes are a characteristic of sexually reproducing diploids and polyploids, a quite different explanation for their presence in bdelloids is suggested by the recent finding that bdelloid rotifers can recover and resume reproduction after suffering hundreds of radiation-induced DNA double-strand breaks per oocyte nucleus. Because bdelloid primary oocytes are in G1 and therefore lack sister chromatids, we propose that bdelloid colinear chromosome pairs are maintained as templates for the repair of DNA double-strand breaks caused by the frequent desiccation and rehydration characteristic of bdelloid habitats.
Levantamento de ninhos de jacarés em savanas inundáveis, Brasil.

As planicies de inundacao ocorrem no Brasil e em outras areas na America do Sul. Algumas dessas sao imensas, como e o caso do Pantanal, do "cerrado" no Estado de Rondonia e das Ilhas do Bananal, mas a maioria se espalha entre mosaicos ao longo de rios como as inundacoes dos rios Amazonas-Solimoes, Sao Francisco e Parana (Mourao et al, 1994). O tamanho da populaccao de jacares que vivem nesses habitats e dificil para contar em levantamentos noturnos (Campos et al., 1995). Isso porque esses habitats ocupam areas extensas e remotas, e tambem pela baixa visibilidade associada a vegetacao flutuante. O levantamento aereo de ninhos pode ser usado para gerar informcao sobre as populacoes de crocodilianos habitantes desses pântanos (Taylor e Neal, 1984; Bayliss, 1987; Mourao et al., 2000). Muitos paises da America do Sul tem usado as populacoes de jacares para obter lucros. A Venezuela e a Guiana tem programas legais de caca (Thorbjarnarson, 1992) enquanto que outros paises como o BRasil e a Colombia tem implementado programas de criacao de jacares (Coutinho et al., 1998). Entretanto, exceto em poucos estudos recentes (Campos, 1993), nao existe tradicao no uso de levantamentos aereos de ninhos de jacares na America do Sul. Neste estudo sao apresentados tres exemplos de uso de levantamentos de ninhos de jacares pelo ar, em diferentes areas de planicies inundaveis no Brasil. Em um caso, foram monitorados ninhos de jacares em fazenda do Pantanal Central durante 5 anos consecutivos e relacionada as densidades dos ninhos com a chuva.
Assessment of Semantic Taxonomies for Blind Indoor Navigation Based on a Shopping Center Use Case

Despite the growing availability of location-based services (LBS) to support pedestrian activities, we know little about the effectiveness of existing geographical web information to assist the indoor navigation of people with special needs such as the visually impaired. To characterize these indoor environments, we surveyed three different specifications about taxonomies for environmental semantic information. Survey results show that even having different scopes, the three studied specifications share considerable environmental semantic information. In order to evaluate the validity of survey results, we created a set of environmental semantic information for a shopping center, and then performed a navigation experiment with 9 visually impaired participants in the same indoor location. A smartphone-based system providing audio navigation assistance based on accurate real-time localization in the shopping center was used to complete navigational tasks. Experiment results show an overall positive assessment from participants about the usefulness of the audio messages used. We present further findings about the assessment of the different audio messages by the study participants.
[Genetic and ophthalmological assessment of patients with type II Stickler syndrome].

PURPOSE To diagnose, evaluate and describe the clinical, genetic and ophthalmic characteristics of a family with type II Stickler syndrome. METHODS X-rays for bone age, clinical and genetic evaluation were performed in all patients with ocular alterations. The Stickler syndrome diagnosis was established after correlating these examinations. RESULTS Type II Stickler syndrome was found in 11 patients. The most important ocular findings were: high myopia (80%), lens subluxation (70%), exotropia (50%) and vitreoretinal abnormalities (80%) including vitreous cavity (50%). The clinical genetic examination disclosed that 30% of the patients had micrognathia, 50% hearing loss, 40% nasal depression and 60% high palate. Seven cases had articular hypermotility and long fingers and arthropathy was present in 3 cases. CONCLUSION Diagnosis of the Stickler syndrome is difficult due to its phenotypic variability and the existence of other genetic syndromes with similar characteristics. Hand and wrist radiographs are of particular importance in the diagnosis of this syndrome.
Broad Inhibition and Local Disinhibition Characterize Local Cortical Circuits

The term “blanket of inhibition” has been proposed to explain the dense and indiscriminate inhibitory connectivity of several classes of GABAergic interneurons with nearby pyramidal neurons ([Karnani et al., 2014][1]). This inhibition is extensive in both space and time. The inhibition extends
End‐Systolic Pressure‐Volume Relation Estimated from Physiologically Loaded Cat Papillary Muscle Contractions

Physiological loads were imposed on contracting isolated cat papillary muscles. The interaction of a hypothetical cylindrical ventricle with a three-element vascular impedance model dictated these physiological loads. The length-tension relation of the physiologically loaded muscle and the pressure-volume relation of the hypothetical ventricle were simultaneously analyzed while the resistive and capacitive components of the vascular impedance were varied widely. Both the end-systolic muscle length-tension relation and the end-systolic ventricular pressure-volume relation were constructed using stepwise increments in either peripheral vascular capacitance or peripheral vascular resistance. The slope of the relation line connecting the end-systolic pressure-volume points under stepwise increases in resistive load was smaller (p < 0.0005) than the slope of this line under stepwise increases in capacitive load. Therefore, the end-systolic pressure-volume relation behaves differently with respect to capacitive and resistive loads. The different loading pattern within the same beat under these varying loading conditions and the coincidence of end-systole with end-ejection in these naturally ejecting contractions are responsible for the shifts in slope of the end-systolic pressure-volume relation. Neither the slope nor the volume intercept of the end-systolic pressure-volume relation was changed when initial muscle length was decreased from 1.0 to 0.95 Imax When the Ca2+ concentration in the bathing solution was increased from 2.5 to 7.5 mM, the slope of the end-systolic pressure-volume relation increased (P < 0.0005), and the volume intercept of the curve decreased (P < 0.025). These results are similar to data reported for conscious animals and to data obtained from catheterization of the human left ventricle. Circ Res 46: 20-26, 1980