Miracle-dz/UniFAR-FTUs huggingface dataset:
Unlocking the potential of HK2 in cancer metabolism and therapeutics.

Glycolysis is a tightly regulated process in which several enzymes, such as hexokinases (HKs), play crucial roles. Cancer cells are characterized by specific expression levels of several isoenzymes in different metabolic pathways and these fea-tures offer possibilities for therapeutic interventions. Overexpression of HKs (mostly of the HK2 isoform) has been con-sistently reported in numerous types of cancer. Moreover, deletion of HK2 has been shown to decrease cancer cell prolif-eration without explicit side effects in animal models, which suggests that targeting HK2 is a viable strategy for cancer therapy. HK2 inhibition causes a substantial decrease of glycolysis that affects multiple pathways of central metabolism and also destabilizes the mitochondrial outer membrane, ultimately enhancing cell death. Although glycolysis inhibition has met limited success, partly due to low selectivity for specific isoforms and excessive side effects of the reported HK inhibitors, there is ample ground for progress. The current review is focused on HK2 inhibition, envisaging the development of potent and selective anticancer agents. The information on function, expression, and activity of HKs is presented, along with their structures, known inhibitors, and reported effects of HK2 ablation/inhibition. The structural features of the different isozymes are discussed, aiming to stimulate a more rational approach to the design of selective HK2 inhibitors with appropriate drug-like properties. Particu-lar attention is dedicated to a structural and sequence comparison of the structurally similar HK1 and HK2 isoforms, aim-ing to unveil differences that could be explored therapeutically. Finally, several additional catalytic- and non-catalytic roles on different pathways and diseases, recently attributed to HK2, are reviewed and their implications are briefly dis-cussed.
Using Deep Learning and 360 Video to Detect Eating Behavior for User Assistance Systems

The rising prevalence of non-communicable diseases calls for more sophisticated approaches to support individuals in engaging in healthy lifestyle behaviors, particularly in terms of their dietary intake. Building on recent advances in information technology, user assistance systems hold the potential of combining active and passive data collection methods to monitor dietary intake and, subsequently, to support individuals in making better decisions about their diet. In this paper, we review the state-of-the-art in active and passive dietary monitoring along with the issues being faced. Building on this groundwork, we propose a research framework for user assistance systems that combine active and passive methods with three distinct levels of assistance. Finally, we outline a proof-of-concept study using video obtained from a 360-degree camera to automatically detect eating behavior from video data as a source of passive dietary monitoring for decision support.
Designing a Mobile Application for Ad-Hoc Tumor Board Scheduling

Tumor boards are multidisciplinary meetings of medical experts who consensually decide about diagnosis and treatment recommendations for cancer patients. They are decisive for treatment quality and patient survival. At the same time, they are highly resource-intensive, time-consuming, and complex to schedule. Hospitals compensate this by scheduling tumor boards well in advance. However, this causes delays in cancer treatment and psychological stress for patients. To address this issue, ad-hoc tumor boards may constitute a viable alternative to traditionally scheduled ones if they are properly supported by information systems and effectively integrated into physicians’ busy and unpredictable work day. In this design science research, we therefore propose (1) a prototypical process of carrying out ad-hoc tumor boards and (2) design features of an information system that supports ad-hoc tumor board scheduling and fosters the intrinsic motivation of physicians to participate in them. The development of the process and the design features has been informed by interviews and surveys conducted in 11 hospitals in Europe. We are currently developing the information system. For future evaluation, we outline the properties of a study with students and a clinical trial.
Important TQM Implementation Contributors in Service oriented Organization like Banks in Pakistan

Subsequent to its growth and exceptional achievements, Total Quality Management (TQM) needs to be implemented out of the Manufacturing industry to service organizations, like Private Banks. Study explores prospects of using Soft TQM and Hard TQM in service oriented organizations and investigates how helpful it can be for growth and development of service focused organizations like private banking sector and sees how TQM can help these Banks to excel in their Organizational Performance. These organizations have been employing various methods to develop this sector, increase its capability to get better place in global market and increase investment in this sector. However, till to date far less work is done to control quality to get better results in this sector. Through quantitative research with 5 point Likert’s scale and Baron and Kenny’s model of moderation, this study will try to demonstrate that the Soft TQM along with Hard TQM can give enormous growth to the service sector by increasing the customer orientation and will be helpful to attain competitive edge. The research has examined the moderating effect of Hard TQM on the relationship of Soft TQM and Organization performance; it is notable from this research that the magnitude of this relationship has increased from 0.401 to 0.421. These results indicate that the use of Hard TQM in the Service oriented Organization like banking sector leads to increase the relationship of Soft TQM and Organizational Performance and gives more power to these organizations to control their quality and thrive on international level.
TheMolecular Genetics and Cellular Mechanisms Underlying Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is an incurable disorder clinically characterised by a sustained elevation of mean arterial pressure in the absence of systemic involvement. As the adult circulation is a low pressure, low resistance system, PAH represents a reversal to a foetal state. e small pulmonary arteries of patients exhibit luminal occlusion resultant from the uncontrolled growth of endothelial and smooth muscle cells. is vascular remodelling is comprised of hallmark defects, most notably the plexiform lesion. PAH may be familial in nature but the majority of patients present with spontaneous disease or PAH associated with other complications. In this paper, the molecular genetic basis of the disorder is discussed in detail ranging from the original identi�cation of the major genetic contributant to PAH andmoving on to current next-generation technologies that have led to the rapid identi�cation of additional genetic risk factors. e impact of identi�ed mutations on the cell is examined, particularly, the determination of pathways disrupted in disease and critical to pulmonary vascular maintenance. Finally, the application of research in this area to the design and development of novel treatment options for patients is addressed along with the future directions PAH research is progressing towards.
Enrichment experiments and infaunal population cycles on a Southern California sand plain:response of the leptostracan Nebalia daytoni and other infauna

Fleld studies on the effects of pulsed ennchments were carried out on mac~ofaunal inver tebrates lnhab~t lng the sandy bottom at a depth of about 20 m off the coast of Southern Cahfornld, USA Contrary to expectation, no members of the commun~ty studied responded p o s ~ t ~ v c l y to patches artiflcially enriched with organlc matenal (kelp, fertilizer, or parcels of fish flesh) Although other members of the leptostracan genus Nebaha respond favorably to carrion and heav~ly enrlched conditions AT dayton], one of the most common anlmals at the study s ~ t e , showed no re5ponse to the enr~chments All other members of the infaunal community dccllned In abundance In en r~ched plots, although the opportunlstlc polychdete Capitella sp recruited heavily Into them In the unennched hab~ ta t , seasonal cycles of abundance were ev~den t for most groups of ~nacrofdunal ~nvertebrates, but were cspec~dllv strong for amph~pods and N daytoni
Intimate Partner Violence: An Inaudible Sound

Intimate partner violence (IPV) is defined as a behavior in an intimate relationship that determines physical, emotional or sexual harms including physical aggression, sexual coercion, psychological abuse and other controlling behaviors on women by her intimate partner. This dreadful violence is pervasive in both low and high income countries and mostly encountered by female population. Likewise, Pakistan is one of the low-income countries where 57.6% women suffer from physical abuse by their intimate partners. Mostly this violence is not reported as people lack awareness about women rights and considers violence as a domestic right. This paper attempts to provide a deep insight about the causes of physical violence in an intimate relation, its health implications along with possible recommendations to overcome it.
On Coupled Common Fixed Point Theorems for Nonlinear Contractions with the Mixed Weakly Monotone Property in Partially Ordered S-Metric Spaces

The main aim of this paper is to establish some coupled common fixed point theorems under a Geraghty-type contraction using mixed weakly monotone property in partially ordered -metric space. Also, we give some sufficient conditions for the uniqueness of a coupled common fixed point. Some examples are provided to demonstrate the validity of our results.
A geodesic finite-difference time-domain model of magnetized plasma

Electromagnetic wave propagation in the Earth-ionosphere cavity presents an interesting challenge for simulations. Three-dimensional latitude-longitude finite-difference time-domain (FDTD) models accounting for the bathymetry, topography and ionosphere have been developed and applied towards a number of applications previously. However, to date most of these models treat the ionosphere as a simple, isotropic exponential conductivity profile. Only recently has a latitude-longitude FDTD model been developed that treats the ionosphere as a magnetized cold plasma. This opens the door to modeling electromagnetic phenomena at higher frequencies and higher altitudes by accommodating more physics. Further, a geodesic (hexagonal-pentagonal) FDTD model that is more efficient, is easier to implement, and executes faster than latitudelongitude models has been recently developed. In this thesis, the magnetized cold plasma global latitude-longitude algorithm is adapted and implemented for the first time in a geodesic FDTD model of the Earth-ionosphere cavity.
Stochastic observers on Lie groups: a tutorial

In this tutorial paper, we discuss the design of geometric observers on Lie groups in the presence of noise. First we review Lie groups, and the mathematical definition of noises on Lie groups, both in discrete and continuous time. In particular, we discuss the Itô-Stratonovich dilemma. Then, we review the recently introduced notion of group affine systems on Lie groups. For those systems, we discuss how using the machinery of Harris chains, (almost) globally convergent deterministic observers might be shown to possess stochastic properties in the presence of noise. We also discuss the design of (invariant) extended Kalman filters (IEKF), and we recall the main result, i.e., the Riccati equation computed by the filter to tune its gains has the remarkable property that the Jacobians (A,C) with respect to the system's dynamics and output map are independent of the followed trajectory, whereas the noise covariance matrices that appear in the Riccati equation may depend on the followed trajectory. Owing to this partial independence, some local deterministic convergence properties of the IEKF for group-affine systems on Lie groups may be proved under standard observability conditions.
Information Revelation in an Insider Trading Model with More Informed Traders

In this paper, we extend Jain and Mirman (2000, 2002), Daher and Mirman (2006, 2007), Wang et al. (2009) and Wang and Wang (2010) on modeling insider trading under Cournot duopoly competition, but focus on changes in the financial side by introducing more owners as insiders, all of whom possess the same inside information and can trade in the stock market. We find that in reality, the output of listed firm decreases but quantity produced by other firm increases, though total output becomes less. Market makers are less responsive to both signals from real and financial sides, but will set stock prices higher with zero signals. The manager and each owner will order fewer stocks in the financial side, but the total order flow still depends upon the realized values of inside information. As the number of insiders increases, the profits of the manager and each owner will decrease correspondingly, so does the variance of the observed inside information. If the number approaches infinity, then all insiders’ profits will also reach zero, and at the same time, there is no variance for the inside information. That is to say, all inside information is revealed to the public so the stock market is perfectly efficient.
Co-variations in litter decomposition, leaf traits and plant growth in species from a Mediterranean old-field succession

Summary 1A growing consensus is developing that the impact of species on ecosystem properties is mediated, at least partially, by the traits of their component species. A previous study demonstrated that the field decomposition of complex litters produced by different communities of a Mediterranean successional sere was related to the average trait value of these communities. Here we scale down to the species level, to test whether similar relationships are found for selected species from these communities. We also test whether litter decomposability can be considered as part of the suite of traits characterizing the fast–slow growth continuum in plants. 2We chose 12 of the most abundant herbaceous species characteristics of three stages of the old-field succession mentioned above. We investigated trait variation and covariation for the eight following traits: specific leaf area (SLA), leaf phosphorus (LPC), nitrogen (LNC) and carbon (LCC) concentrations, leaf dry matter content (LDMC) and leaf total phenols (TPh), all on material collected in the field; and litter decomposability (Kpot) and maximum relative growth rate (RGRmax), obtained under standardized conditions in the laboratory. 3Five of these traits were significantly lower in species from the advanced successional stage. These trends were similar when comparisons were conducted either with the 12 species, or on a subset incorporating taxonomic information. LDMC was the single trait best correlated with species RGRmax and Kpot; the two latter traits were also significantly correlated with one another. 4These results provide clear evidence of functional links between plant growth, leaf traits and litter decomposability. LDMC appears as a pivotal trait of living leaves related to their structural properties. It influences the quality of the litter produced, and hence species’ potential ‘after-life effects’ on ecosystem properties.
Trace Elements and Radionuclides in Urban Air Monitored by Moss and Tree Leaves

In urban areas, air quality is strongly influenced by numerous anthropogenic activities. High population density, heavy traffic and domestic heating in winters in the centre, and various industrial activities at the outskirts, influence atmospheric concentrations of trace elements and radionuclides. Consequently, large population is exposed to possible adverse effects arising from the altered urban air composition. Therefore, air quality monitoring has become one of the standard quality control procedures in urban areas.
Color Scheme Search: A Statistics-Based IEC Method

This paper presents a statistics-based interactive evolutionary computation (IEC) method for color scheme search. Color schemes are utilized in an enormous range of items such as websites, clothing, advertising media, and housewares. However, people who do not have sufficient skill or knowledge of colors need to devote considerable time and effort to a creating color scheme. Currently, artists' color schemes are freely available from websites. However, obtaining an appropriate color scheme from a large data set is difficult for novice users. To overcome this problem, we rely on a statistics-based interactive genetic algorithm (IGA). Use of this IGA is expected to reduce computing costs compared with conventional IEC approaches and to take overall color scheme impressions into account. These contributions enable to realization of the kansei-based color search system in real time. In addition, we introduce four similarity search (SS) functions (hue, saturation, brightness, and color differences) to facilitate the convergence of a color scheme search. The combination of a statistics-based IGA and four SS functions allows users to easily and effectively find their desired color schemes. To investigate the performance of the proposed method, we conducted two experiments and confirmed that the implemented application allows users to obtain a desired color scheme in less than 48 s. In addition, we also confirmed that the proposed method can provide some favorable recolored illustrations in less than 52 s.
The development of home dialysis in Australia

The history of the development of home dialysis provides a fascinating niche study in the history of nephrology. An understanding of the fundamental physiological and socio-economic background to it is essential if one wishes to acquire a balanced perception of the development of this form of treatment; and an understanding of the international background is necessary if one wishes to understand the history of its development in Australia
Mechanisms, Determinants and Model of Early Succession on the Lateritic Plateau of the Sahelian Part of Western Niger

Western Niger lateritic plateaux formally occupied by tiger bush are mainly secondary ecosystems affected by crusting and soil compaction that impedes infiltration and induces intense erosion, which hampered lowlands millet fields. Restoration of these plateaux is essential, but, failure is frequently reported about early species establishment. It’s therefore necessary to examine the mechanisms and factors of early plants recovery which are important for vegetation restoration. Vegetation data have been recorded in 31 plots, at four sites with similar environmental characteristics and different land use histories: Unrevegetated area, 1-3-years old revegetated area, 6-years old revegetated area and 14-years old revegetated area. We also measured 16 environmental variables in each plot to examine the driving forces of succession and the vegetation-environment relationships. TWINSPAN results revealed that plant species could be classified into six plant communities representing 4 succession stages. The DCA confirm TWINSPAN classification and indicated two gradients of succession: land condition and successional age. According to the CCA and the Monte Carlo tests, the determinants of succession are succession age, covers of gravel crusts, erosive crusts, barren soil, plants and litter, soil pH, soil contents of organic carbon, organic matter, available phosphorus, calcium, magnesium, total of basic cations and Cation exchange capacity. The chronological changes in plant communities associated with environmental variables contribute to plant assemblage and vegetation development. Since, the environmental variables are able to change with succession age, succession pathways can be divergent, but in the present study it becomes convergent at late stage. As each stage can be structured by more than one plant community, the model of restoring degraded lateritic is closer to alternative stable states model.
ANNALES DE L’INSTITUT FOURIER

— We formulate a notion of purity for p -adic big Galois represen- tations and pseudorepresentations of Weil groups of ‘ -adic number ﬁelds for ‘ 6 = p . This is obtained by showing that all powers of the monodromy of any big Galois representation stay “as large as possible” under pure specializations. Using purity for families, we improve a part of the local Langlands correspondence for GL n in families formulated by Emerton and Helm. The role of purity for families in the study of variation of local Euler factors, local automorphic types along irreducible components, intersection points of irreducible components of p -adic families of automorphic Galois representations is illustrated using the examples of Hida families and eigenvarieties. Résumé. — Nous formulons une notion de pureté pour les familles p -adiques de représentations galoisiennes et pseudo-caractères du groupe de Weil d’un corps de nombres ‘ -adiques pour ‘ 6 = p . Ceci est obtenu en montrant que tous les puissances de la monodromie de toute représentation galoisienne restent aussi grandes que possible après spécialisations pures. En utilisant la pureté pour les familles, nous améliorons une partie de la correspondance de Langlands locale pour GL n en familles formulée par Emerton et Helm. De plus, en utilisant les exemples de familles de Hida et variétés de Hecke, nous illustrons le rôle de pureté pour les familles dans l’étude de la variation des facteurs d’Euler locaux, types automorphes locaux le long des composantes irréductibles, les points d’intersection des composantes irréductibles de familles de représentations galoisiennes automorphes.
A Granger Causality Test of the Hayek-Friedman Hypothesis: Must Political Freedom and Economic Freedom Coexist?

Throughout their careers both Frederick von Hayek and Milton Friedman preached the unequaled virtues of freedom of choice. Their support of free-market economies was persistent throughout their lives. Their thoughts and positions on this matter had been clearly and consistently made clear. It remains for others who follow to assess their relative positions and evaluate their contributions to the discussion of the role of economic capitalism in a political state. This paper offers an empirical examination of the HayekFriedman Hypothesis which argues that societies with high levels of political freedom must also have high levels of economic freedom. Granger-causality tests are performed to identify directionality between levels of economic freedom and two separate, distinct measures of political freedom.
Bullying in Early Adolescence: The Role of the Peer Group. ERIC Digest.

La intimidacion en el comienzo de la adolescencia: La funcion del grupo social (Bullying in Early Adolescence: The Role of the Peer Group). ERIC Digest. 2 DEFINICIONES DE LA INTIMIDACION. 2 LA ACEPTACION POR LOS COMPANEROS Y EL ESTATUS SOCIAL. 3 EL DESARROLLO DE SITUACIONES DE INTIMIDACION EN LOS GRADOS INTERMEDIOS. 3 LA TRANSICION A LOS GRADOS INTERMEDIOS Y LA ADAPTACION SOCIAL. 4 CONCLUSION. 5 PARA MAS INFORMACION. 5