Miracle-dz/UniFAR-FTUs huggingface dataset:
On The Multi-Stage Optimization In Supply Chain (A Case Study of WEMY Industries Limited)

This work proposes a new mathematical model based on a multi-objective solution for the optimization problem in supply chain. The analyzed supply chain includes the suppliers, manufacturers, distribution centers and wholesalers, considering that orders come from customers to wholesalers. A mathematical model that solves the optimization problem regarding durations and costs in the execution of customer orders is proposed. Many constraints are supported in this mathematical model such as suppliers and manufacturers capacities and balanced stocks. The aim of the proposed method is to find a near-optimal solution that minimizes criteria of cost and time along the whole supply chain process. The mathematical model was tested on WEMY Industries Limited supply chain, the results obtained by executing the heuristics approach and the mathematical model shows that it is more efficient than the heuristic. The GAP 15.02 % gotten from the proposed model improves the actual solution, this will assist in reducing costs of production and transportation of the goods and profit will be maximized as the customer of physical distribution and logistics emerged in the 1960s and 1970s. In the 1990s, a new name emerges: “Supply demands are meant genuinely respecting the delivery date of the customer. Keyword: Supply Chain Management, Optimization, Linear program, Coordination & Logistics. Aims Research Journal Reference Format: Oyekan, E.A. , Ewebajo, O.A. & Temisan Gabriel O. (2019 On The Multi-Stage Optimization in Supply Chain (A Case Study of WEMY Industries Limited). Advances in Multidisciplinary Research Journal. Vol. 5. No. 1, Pp 61–74. Article DOI: dx.doi. org/10.22624/AIMS/V5N1P7 Available online at www.aimsjournal. net
High levels of circulating cytomegalovirus DNA reflect visceral organ disease in viremic immunosuppressed patients other than marrow recipients.

Although viremia is a hallmark of disseminated cytomegalovirus (CMV) infection, not all viremic patients have visceral organ CMV disease. We used blot hybridization with a cloned subgenomic probe to quantitate viral DNA in blood leukocytes of 60 viremic patients (25 with solid organ transplants, 20 with AIDS, and 15 marrow recipients) who had different clinical manifestations of CMV infection. The results are expressed as pg of viral DNA/10 micrograms of leukocyte DNA. Patients with AIDS or with solid organ transplants who had CMV visceral organ disease had the largest amounts of viral DNA in their granulocytes (median 632 and 237 pg, respectively). These amounts were significantly greater than those in similar viremic patients without CMV visceral disease (17 and 21 pg; P < 0.005 and 0.002, respectively). All patients in the study with > 150 pg of CMV DNA in their granulocytes had visceral CMV disease. The amounts of viral DNA in granulocytes of AIDS and organ transplant patients with CMV retinitis were low (median 22 pg). Marrow transplant patients were unique in that the amounts of CMV DNA in granulocytes were low whether CMV visceral organ disease was present (17 pg) or absent (14 pg). We conclude that high levels of circulating CMV DNA in viremic AIDS and solid organ transplant patients reflect viral involvement of visceral organs but not the retina. In marrow recipients, the severity of CMV disease, even when fatal, is not reflected quantitatively in peripheral blood leukocytes.
The Relationship between Corporate Real Estate and Economic Cycle

Studies on the relationship between corporate real estate (CRE) and economic cycles are very thin, especially from developing countries, such as South Africa. More, in practice, most firms hardly dedicate enough resources to CRE divisions. This leads to that management not fully maximises the wealth of shareholders. This study uses multi-linear regression to test how GDP, interest rate, and total corporate costs react to changes in CRE. The sample is made up of blue chip firms listed on the Johannesburg Stock Exchange (JSE). The results reveal mixed bag solutions-for certain firms; GDP, interest rate, and corporate costs are statistically significant and vice versa. More, this analysis can be replicated to other similar industries and indices around the world.
Fluid balance, dry weight, and blood pressure in dialysis

The total amount of sodium present in the body controls the extracellular volume. In advanced renal failure, sodium balance becomes positive and the extracellular volume expands. This leads to hypertension, and vascular changes that lead to adverse cardiovascular consequences in dialysis patients. Controlling the body sodium content and the extracellular volume allows one to better control hypertension and its consequences. This can be achieved by reducing the sodium input (sodium dietary restriction and reasonably low sodium dialysate) and/or by increasing the sodium output (ultrafiltration by convection). The discontinuous nature of hemodialysis causes saw‐tooth volume fluctuations. This has led to the concept of dry weight (DW), a crucial component of dialysis adequacy. Assessment and achievement of DW is feasible on pure clinical grounds. But its relative lack of accuracy (and the physicians' progressive lack of interest in bedside examination) has led to several nonclinical methods of assessing DW in an effort to improve the assessment of fluid status in dialysis patients.
Chapter 1 Introduction

Since 1960, the considerable efforts have been made to maximize the utilization of the fish for human consumption (Sonu, 1986; Leonar Nunes et al., 1990). Decrease in supply of lean fish, particularly Alaska pollack, for surimi production forces surimi manufacturers seeking for a new source of raw material especially from underutilized fish species such as pelagic fish (Sonu, 1986). Based on consumer and economic perspectives, there has been a little success on making acceptable surimi from those pelagic fish, though the substantial improving process on gel strength of surimi from the fishes have been established since Shimizu (1965) patented his alkaline washing process. Hultin and Kelleher (2000) pointed out several limiting factors on using the dark muscle fish as surimi raw material and the primary constraint is their high content of dark muscle.
A method for obtaining protein concentrates from microorganisms

In order to isolate proteins from microalgae, yeasts and bacteria, cell disintegration in a special ball‐mill was performed. The degree of disintegration of the different microorganisms was compared. The dependence of disintegration on bead size and on the ratio between the volume of suspension and the volume of glass beads was also investigated. Nondisintegrated and disintegrated cells were extracted with sodium hydroxide and the amount of extractable nitrogen and the amount of nitrogen precipitable at pH 4.0 were determined. The dependence of yield on the sodium hydroxide concentration, extraction time, and temperature was studied. When extracting undisintegrated cells, very low yields were obtained and the nitrogen extracted was mostly nonproteinous. For disintegrated cells high yields were obtained. An optimum was found after extraction with 0.3–0.5% sodium hydroxide; at pH 11.0–11.5. The precipitate obtained represented 60–70% of the cell nitrogen. The nitrogen content of the precipitate was 12–14% of the dry weight.
FGF13 regulates proliferation and differentiation of skeletal muscle by down‐regulating Spry1

Generally, the secretory forms of FGF are known to regulate cell proliferation, differentiation and morphogenesis by binding to the extracellular domain of cell surface receptors. Intracellular FGFs (FGF11‐14) are expressed principally in the nervous system. FGF13 is a microtubule‐stabilizing protein that regulates neuronal polarization and migration. Previous studies have reported high expression of FGF13 in cultures of single muscle fibres. However, functions of FGF13 in muscle development have not been explored.
Beyond species: functional diversity and the maintenance of ecological processes and services

Summary 1. The goal of conservation and restoration activities is to maintain biological diversity and the ecosystem services that this diversity provides. These activities traditionally focus on the measures of species diversity that include only information on the presence and abundance of species. Yet how diversity influences ecosystem function depends on the traits and niches filled by species. 2. Biological diversity can be quantified in ways that account for functional and phenotypic differences. A number of such measures of functional diversity (FD) have been created, quantifying the distribution of traits in a community or the relative magnitude of species similarities and differences. We review FD measures and why they are intuitively useful for understanding ecological patterns and are important for management. 3. In order for FD to be meaningful and worth measuring, it must be correlated with ecosystem function, and it should provide information above and beyond what species richness or diversity can explain. We review these two propositions, examining whether the strength of the correlation between FD and species richness varies across differing environmental gradients and whether FD offers greater explanatory power of ecosystem function than species richness. 4. Previous research shows that the relationship between FD and richness is complex and context dependent. Different functional traits can show individual responses to different gradients, meaning that important changes in diversity can occur with minimal change in richness. Further, FD can explain variation in ecosystem function even when richness does not. 5. Synthesis and applications. FD measures those aspects of diversity that potentially affect community assembly and function. Given this explanatory power, FD should be incorporated into conservation and restoration decision-making, especially for those efforts attempting to reconstruct or preserve healthy, functioning ecosystems.
Biomarkers of 3‐Nitropropionic Acid (3‐NPA)‐Induced Mitochondrial Dysfunction as Indicators of Neuroprotection

Abstract: In humans or animals, symptoms of mitochondrial energy dysfunction may be produced by mutations or inborn errors of the necessary enzymes, as well as by enzyme inhibitors or uncouplers of the oxidative phosphorylation process. 3‐Nitropropionic acid (3‐NPA) is a toxin that is sometimes produced on moldy crops (sugarcane, peanuts, etc.) in amounts sufficient to cause severe neuromuscular disorders when consumed by humans. In vitro, 3‐NPA irreversibly inactivates SDH, a Complex II respiratory enzyme important for mitochondrial energy production. We have been studying biomarkers of 3‐NPA exposure in the expectation that such markers may be useful in the screening process to identify neuroprotective agents against neurotoxicity produced by mitochondrial energy dysfunction. Animals were sacrificed at various times after 3‐NPA exposure for histochemical visualization of SDH activity and measurement of immediate postmortem rectal temperature. 3‐NPA‐treated rats experienced progressive hypothermia that reached a loss of 3°C or more in core body temperature by three hours after dosing. The optical density of the SDH stain in brain was reduced, following a similar time course, most prominently in the cerebellum and least sharply in the thalamus. Some rats were given injections of l‐carnitine (an enhancer of fatty acid transport) either alone, or as a pretreatment prior to a dose of 3‐NPA. Although l‐carnitine deficiency by itself can produce mitochondrial dysfunction, pretreatment with l‐carnitine was of limited efficacy at overcoming the effects of 3‐NPA on either body temperature or quantitative SDH histochemistry. Body temperature and SDH histochemistry may be useful biomarkers for evaluating the efficacy of neuroprotective agents against lower doses of 3‐NPA, against other pharmacological models of mitochondrial dysfunction, or even against genetic mitochondrial diseases.
Aproximación del Mapa de Disparidad Estéreo Mediante Técnicas de Aprendizaje Automático

El objetivo de este trabajo es abordar el problema del calculo del mapa de disparidad de un par de imagenes estereo. En lugar de considerar los metodos clasicos para calcular el mapa de disparidad a partir de dos imagenes, se va a tomar una aproximacion basada en tecnicas de aprendizaje automatico. El calculo de la disparidad se considerara un mero problema de clasificacion y se entrenara un clasificador cuyo objetivo alcanzar un rendimiento igual o superior al de los metodos clasicos. Para solucionar el problema de la falta de imagenes reales con los verdaderos mapas de disparidad conocidos, se va a presentar una tecnica original de generacion sintetica de imagenes con disparidad conocida que puedan usarse para entrenar el clasificador y aplicarse a imagenes reales. Aśi mismo, se introduciran las caracteŕisticas utilizadas para entrenar el clasificador, el tipo de clasificador a utilizar, se compararan los resultados obtenidos con los de los metodos clasicos y se propondran nuevas ĺineas de investigacion en base a los resultados de este trabajo.
Pathology Classification of Gait Human Gestures

Gait patterns may be distorted in a large set of pathologies. In the clinical practice, the gait is studied using a set of measurements which allows identification of pathological disorders, thereby facilitating diagnosis, treatment and follow up. These measurements are obtained from a set of markers, carefully placed in some specific anatomical locations. This conventional procedure is obviously invasive and alters the natural movement gestures, a great drawback for diagnosis and management of the early disease stages, when accuracy is a crucial issue. Instead, markerless approaches attempt to capture the very nature of the movement with practically no intervention on the movement patterns. These techniques remain still limited concernig their clinical applications since they do not segment with sufficient precision the human silhouette. This article introduces a novel markerless strategy for classiying normal and pathological gaits, using a temporal-spatial characterization of the subject from 2 differents views. The feature vector is constructed by associating the spatial information obtained with SURF and the temporal information from a Σ-∆ operator. The strategy was evaluated in three groups of patients: normal, musculoskeletal disorders and parkinsons disease, obtaining a precision and a recall of about 60%
Fertility desires and preferences for safer conception strategies among people receiving care for HIV at a publicly-funded clinic in Seattle, WA

ABSTRACT Understanding fertility desires and preferences for HIV prevention among individuals living with HIV, including the potential use of pre-exposure prophylaxis (PrEP) by HIV uninfected partners, can inform the delivery of safer conception counseling to reduce the risk of HIV transmission during pregnancy attempts. Men and women, predominantly heterosexual, engaged in HIV care in Seattle, WA, self-administered a questionnaire and we abstracted antiretroviral therapy (ART) status and HIV viral levels from medical records. We summarized participants’ sexual behavior, fertility desires, and preferences for safer conception strategies and used log-binomial regression to identify demographic, sexual, and behavioral factors associated with perceived acceptability of PrEP for HIV uninfected partners during pregnancy attempts. 52% of the 150 participants were female and the mean age was 48 years (range 23–74). 94.7% of participants were using ART and 79.3% had HIV viral load < 40 copies/mL. 22.2% of men and 34.6% of women reported that a healthcare provider had initiated discussion about fertility desires. 28.7% of participants were reproductive-age and desired children. Among sexually active reproductive-age participants with fertility desires, 56.3% reported inconsistent condom use and 62.5% did not report using effective birth control. 74.4% of reproductive age participants with fertility desires perceived that PrEP would be acceptable to an HIV uninfected partner and there were no significant predictors of PrEP acceptability. Nearly one third of reproductive-aged individuals living with HIV expressed fertility desires, highlighting a need for safer conception counseling in this setting. PrEP and ART were favored safer conception strategies.
Shape Retrieval and 3D Gestural Interaction

Despite the emerging importance of Virtual Reality and immersive interaction research, no papers on application of 3D shape retrieval to this topic have been presented in recent 3D Object Retrieval workshops. In this paper we discuss how geometric processing and geometric shape retrieval methods could be extremely useful to implement effective natural interaction systems for 3D immersive virtual environments. In particular, we will discuss how the reduction of complex gesture recognition tasks to simple geometric retrieval ones could be useful to solve open issue in gestural interaction. Algorithms for robust point description in trajectories data with learning of inter-subject invariant features could, for example, solve relevant issues of direct manipulation algorithms, and 3D object retrieval methods could be used as well to build dictionaries and implement guidance system to maximize usability of natural gestural interfaces.
Isoniazid and Rifampicin as Therapeutic Regimen in the Current Era: A Review

Tuberculosis represents one of the biggest challenges in the medical field. According to World Health Organization (WHO) Global Tuberculosis Report, 2012, there were estimated 8.7 million new TB cases worldwide while 1.4 million people died of TB. Additionally, 90% of the cases of TB are reported in developing countries, with India having the largest number of incident cases. The current treatment method includes the administration of a cocktail of drugs which includes Isoniazid (INH), Rifampicin (RIF), Ethambutol (EMB) and Pyrazinamide (PZA) which are referred to as the first line of drugs. Isoniazid and Rifampicin are currently the two most powerful anti-TB medications. The occurrences of multi-drug and extensive-drug resistant strains (MDR-TB and XDR-TB, respectively) have become a global concern and pose a serious challenge for public health management. Treatment of these resistant cases involves the usage of the second line of anti-tuberculosis drugs which are less effective than the first line and are known to cause adverse reactions or toxic side-effects. Tuberculosis research should not only focus on treatment methods but also on management of the current cases of resistance and measures to prevent an outbreak of resistant TB infection. This review outlines the mechanism of action of isoniazid and rifampicin and how resistance to these drugs emerges. We also provide a brief insight into the prevalence of HIV in TB patients and the challenges associated with treatment regimens in this co-infection.
Operation of the Information Monitoring System for the Optimization of the Processing Time and the Dissemination of Financial Data

In this paper, we propose the concept of "information monitoring system "; we indicate its usefulness in the process of informative anticipatory system, in the face of the problem of financial information overload caused by the use of ICT. We present a grid of analysis of the accounting process in an indebted company. The concept is useful when the information intelligence is oriented "exploitation of the information anticipatory" for the anticipation, these being embedded in large financial data. Our experimentation on the problem studied will show us that these tools are effective to optimize the time of processing and dissemination of financial information for decision-making.
Enhancing assessment of interpersonal violence (IPV) pregnancy‐related homicide risk within nursing curricula

&NA; Pregnancy and motherhood traditionally represent evolution of the next generation; yet, contemporary research and analyses confirm that this time can also be manifested in fear by the expectant mother within an environment of battering, cruelty, physical and emotional abuse, and sexual assault. Often to the surprise of many healthcare providers, the Centers for Disease Control and Prevention have consistently reported that Interpersonal Violence (IPV) related homicide is a leading cause of traumatic death among new and expectant mothers. In spite of these staggering statistical and anecdotal findings, universal screening for violence during pregnancy continues to be minimal. Forensic nurses might be prompted to respond to the consequences of violence and its resultant negative effects on expectant mothers by strategically incorporating systematic and consistent assessment into foundational nursing curricula regarding IPV as a leading risk factor for injury or death.
Exocytosis and Selective Neurite Calcium Responses in Rat Cerebellar Granule Cells During Field Stimulation

The free calcium concentration, [Ca2+]c, in fura‐2‐loaded rat cerebellar granule cells was investigated by digital imaging during trains of uniform field stimuli in order to compare the ability of calcium channels in somata and neurites to respond to brief, physiologically relevant depolarizations. Very few somata responded to 20 Hz trains of 1 ms pulses, while virtually all neurites showed an extensive increase which was rapidly reversed when stimulation was terminated. In contrast, both somata and neurites responded when cells were depolarized with 50 mM KCl. The field stimuli evoked a tetrodotoxin‐sensitive increase in Na+ concentration in both somata and neurites. When 4‐aminopyridine, which inhibits delayed K+ currents in these cells, was present during the field stimulus both somata and neurites increased their [Ca2+]c, suggesting that prolongation of the duration of depolarization is required for somatic Ca2+ channel activation. The neurite response did not depend on the orientation of the neurite relative to the applied field. The neurite response was insensitive to nifedipine (1 μM) and ω‐agatoxin‐IVA (30 nM) but was uniformly inhibited by ω‐conotoxin‐GVIA (30% inhibition at 1 μM) and ω‐conotoxin‐MVIIC (44% inhibition at 5 μM). The two inhibitors were not additive. The neurite [Ca2+]c response was insensitive to the combination of ionotropic glutamate receptor antagonists. Field stimulation caused the exocytosis of the fluorescent probe FM1‐43 previously loaded during KCl depolarization, suggesting that presynaptic Ca2+ channels contribute to the field‐evoked neurite response.
O data mining na compreensão do fenómeno da dor: uma proposta de aplicação

Resumo: A Dor, fenomeno dificil de compreender, tem sido objecto de estudo na Medicina. A sua natureza subjectiva faz com que as variaveis em estudo devam ter um âmbito alargado, que permita caracterizar convenientemente este fenomeno. A compreensao deste fenomeno pode ser facilitada com recurso a tecnicas de Data Mining, suportadas, ou nao, por Data Warehouses. O Clinical Data Mining tem sido utilizado para identificar as melhores terapias para diversas doencas, para explorar os factores de sucesso/insucesso das cirurgias e para determinar padroes diversos. O Clinical Data Warehouse consiste num repositorio de dados optimizado para facilitar a analise de dados clinicos. Este artigo apresenta os conceitos associados ao Clinical Data Mining e Clinical Data Warehouse, assim como apresenta um conjunto de variaveis relevantes para a compreensao da dor. Esta compreensao sera realizada recorrendo a tecnicas de Data Mining, na analise de uma Base de Dados cuja estrutura e tambem aqui apresentada.