Miracle-dz/UniFAR-FTUs huggingface dataset:
PERITONEAL DIALYSIS-RELATED INFECTIONS RECOMMENDATIONS: 2010 UPDATE

Department of Medicine and Therapeutics,1 Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; University of Pittsburgh School of Medicine,2 Pittsburgh, PA, USA; Faculdade de Enfermagem, Nutrição e Fisioterapia,3 Pontifícia Universidade Católica do Rio Grande do Sul, Brazil; Sanjay Gandhi Postgraduate Institute of Medical Sciences,4 Lucknow, India; Department of Nephrology,5 Princess Alexandra Hospital, and School of Medicine, University of Queensland, Brisbane, Australia; Department of Medical Microbiology,6 Leiden University Medical Center, Leiden, The Netherlands; Centre for Kidney Diseases,7 Mount Elizabeth Medical Centre, Singapore; Section of Infectious Disease,8 Department of Internal Medicine, University of Missouri-Columbia School of Medicine, Columbia, MO, USA; Pediatric Nephrology Division,9 University Children’s Hospital, Heidelberg, Germany; Dianet Dialysis Centers,10 Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
A comparison of FPGAs, GPUS and CPUS for Smith-Waterman algorithm (abstract only)

The Smith-Waterman algorithm is a key technique for comparing genetic sequences. This paper presents a comprehensive study of a systolic design for Smith-Waterman algorithm. It is parameterized in terms of the sequence length, the amount of parallelism, and the number of FPGAs. Two methods of organizing the parallelism, the line-based and the lattice-based methods, are introduced. Our analytical treatment reveals how these two methods perform relative to peak performance when the level of parallelism varies. A novel systolic design is then described, showing how the parametric description can be effectively implemented, with specific focus on enhancing parallelism and on optimizing the total size of memory and circuits; in particular, we develop efficient realizations for compressing score matrices and for reducing affine gap cost functions. Promising results have been achieved showing, for example, a single XC5VLX330 FPGA at 131MHz can be three times faster than a platform with two NVIDIA GTX295 at 1242MHz.
Mining Maximal Frequent Patterns in a Unidirectional FP-tree

从稠密的数据库的经常的模式的 Becausemining 完全的集合能是不切实际的，一种有趣的选择最近被建议了。 而不是采矿经常的模式的完全的集合，新模型仅仅发现最大的经常的模式，它能产生所有经常的模式。 FP 生长算法是到目前为止出版的最有效的经常模式的采矿方法之一。 不管多么因为 FP 树和有条件的 FP 树一定是双向的能横过，很多存储器在采矿的过程被需要。 这份报纸为采矿建议有效算法 Unid_FP 最大最大的经常的模式基于单向性的 FP 树。 因为单向性的 FP 树和有条件的单向性的 FP 树的产生方法，算法把空间消费归结为最大程度。 与罐头切了的二条 techniques:single 路径修剪并且头桌子修剪的发展击倒在采矿过程递归地产生的许多有条件的单向性的 FP 树， Unid_FP 最大进一步降低时空的开销。
Reporting of planned statistical methods in published surgical randomised trial protocols: a protocol for a methodological systematic review

Introduction Poor reporting can lead to inadequate presentation of data, confusion regarding research methodology used, selective reporting of results, and other misinformation regarding health research. One of the most recent attempts to improve quality of reporting comes from the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) Group, which makes recommendations for the reporting of protocols. In this report, we present a protocol for a systematic review of published surgical randomised controlled trial (RCT) protocols, with the purpose of assessing the reporting quality and completeness of the statistical aspects. Methods We will include all published protocols of randomised trials that investigate surgical interventions. We will search MEDLINE, EMBASE, and CENTRAL for relevant studies. Author pairs will independently review all titles, abstracts, and full texts identified by the literature search, and extract data using a structured data extraction form. We will extract the following: year of publication, country, sample size, description of study population, description of intervention and control, primary outcome, important methodological qualities, and quality of reporting of planned statistical methods based on the SPIRIT guidelines. Ethics and dissemination The results of this review will demonstrate the quality of statistical reporting of published surgical RCT protocols. This knowledge will inform recommendations to surgeons, researchers, journal editors and peer reviewers, and other knowledge users that focus on common deficiencies in reporting and how to rectify them. Ethics approval for this study is not required. We will disseminate the results of this review in peer-reviewed publications and conference presentations, and at a doctoral independent study of oral defence.
Experimental and modeling study of breakage and restructuring of open and dense colloidal aggregates.

In this work we present experimental and simulation analysis of the breakage and restructuring of colloidal aggregates in dilute conditions under shear. In order to cover a broad range of hydrodynamic and interparticle forces, aggregates composed of primary particles with two sizes, d(p) = 90 and 810 nm, were generated. Moreover, to understand the dependence of breakage and restructuring on the cluster structure, aggregates grown under stagnant and turbulent conditions, having substantially different initial internal structures with fractal dimension d(f) equal to 1.7 and 2.7, respectively, were used. The aggregates were broken by exposing them to a well-defined elongational flow produced in a nozzle positioned between two syringes. To investigate the evolution of aggregate size and morphology, respectively, the mean radius of gyration, , and d(f) were monitored during the breakup process using light scattering and confocal laser scanning microscopy. It was found that the evolution of aggregates' fractal dimension during breakage is solely controlled by their initial structure and is independent of the primary particles size. Similarly, the scaling of the steady-state vs the applied hydrodynamic stress is independent of primary particle size, however, depends on the history of aggregate structure. To quantitatively explain these observations, the breakage process was modeled using stokesian dynamics simulations incorporating DLVO and contact interactions among particles. The required flow-field for these simulations was obtained from computational fluid dynamics. The complex flow pattern was simplified by considering a characteristic stream line passing through the zone with the highest hydrodynamic stress inside the nozzle, this being the most critical flow condition experienced by the clusters. As the flow-field along this streamline was found to be neither pure simple shear nor pure extensional flow, the real flow was approximated as an elongational flow followed by a simple shear flow, with a stepwise transition between them. Using this approach, very good agreement between the measured and simulated aggregate size values and structure evolution was obtained. The results of this study show that the process of cluster breakup is very complex and strongly depends on the initial aggregate structure and flow-field conditions.
Aerobic training increases pain tolerance in healthy individuals.

UNLABELLED The hypoalgesic effects of acute exercise are well documented. However, the effect of chronic exercise training on pain sensitivity is largely unknown. PURPOSE To examine the effect of aerobic exercise training on pain sensitivity in healthy individuals. METHODS Pressure pain threshold, ischemic pain tolerance and pain ratings during ischemia were assessed in 24 participants before and after 6 wk of structured aerobic exercise training (n = 12) or after 6 wk of usual physical activity (n = 12). The exercise training regimen consisted of cycling three times per week for 30 min at 75% of maximal oxygen consumption reserve. RESULTS Significant increases in aerobic fitness (P = 0.004) and ischemic pain tolerance (P = 0.036) were seen in the exercise group after training, whereas pressure pain threshold and pain ratings during ischemia were unchanged (P > 0.2). No change in aerobic fitness (P > 0.1) or pain sensitivity (P > 0.1) was observed in the control group. CONCLUSION Moderate- to vigorous-intensity aerobic exercise training increases ischemic pain tolerance in healthy individuals.
Three distinct forms of insulin-like growth factor binding proteins are released by decidual cells in culture.

Recent studies have shown that human decidual explants synthesize a 25,272 dalton form of insulin-like growth factor binding protein (IGFBP-1) that is identical to the most abundant form of IGFBP detected in human amniotic fluid. To determine whether decidual cells also secrete other structurally distinct forms of IGFBP, conditioned medium obtained from human decidual cells was analyzed by ligand blotting and immunoblotting using antisera that were specific for IGFBP-1 or 2. IGFBP-2 is a form of binding protein that is structurally distinct from IGFBP-1. Ligand blotting analysis (which detects all forms of IGFBPs) showed that 3 forms of IGFBP with Mr estimates of 34,000, 30,000 and 24,000 were present in basal, unstimulated, conditioned media. Immunoblotting showed that the 30,000 Mr form reacted with an antibody that is specific for IGFBP-1, whereas the 34,000 Mr form reacted with an antibody that is specific for IGFBP-2. The 24,000 Mr band did not react with antisera to either IGFBP-1 or 2. Basal IGFBP-1 release from human decidual cultures, as measured by RIA, showed a significant decrease during the 5 day period from 34 +/- 1.6 on day 1 to 12 +/- 1.9 ng/ml on day 5. Exposure of the cells to (Bu)2cAMP (1.0 mM) for 5 days had no significant effect on IGFBP-1 release during the first day of exposure, but caused a progressive stimulation of release during the subsequent 4 days. By day 5, exposure to (Bu)2cAMP induced a 5- to 6-fold increase in IGFBP-1 release that was completely inhibited by exposure to cycloheximide. Exposure of the cells to cholera toxin (0.1 micrograms/ml) for 4 days caused a 3.7-fold increase in IGFBP-1 release. The stimulation of IGFBP-1 release by (Bu)2cAMP was completely inhibited by simultaneous exposure to insulin (100 ng/ml) and/or IGF-I (100 ng/ml) (day 5 control = 35 ng/ml, (Bu)2cAMP alone = 248 ng/ml, insulin + (Bu)2cAMP = 36 ng/ml, or IGF-I + (Bu)2cAMP = 10.1 ng/ml). Hydrocortisone and the phorbol ester (phorbol myristate acetate) caused no significant changes in basal IGFBP-1 release but prevented the decrease in the basal rate of release that occurred between day 1 and 5. Ligand blotting studies showed that the 24,000 Mr form of binding protein was also stimulated by (Bu)2cAMP (3.3-fold increase); however, cholera toxin and phorbol myristate acetate were without effect. In contrast, the release of the 34,000 Mr form was unaffected by exposure to any of these agents, suggesting that regulation of this form of IGFBP is distinct from the other 2 forms. (ABSTRACT TRUNCATED AT 400 WORDS)
Suppressing mode instabilities by optimizing the fiber coiling methods

Suppressing mode instabilities (MI) by optimizing the fiber coiling methods has been studied numerically. By employing our semi-analytical model, the MI threshold of two typical high power fibers in various coiling methods has been calculated. It reveals that fiber laser systems with gain fibers being coiled in cylinder shape has higher MI threshold than those with gain fibers being coiled in spiral shape, and MI-free output power of fiber lasers can be scaled up to above 3 kW even with the typical commercial fibers in the co-pumped configurations.
Evaluation of a Model for the Treatment of Combined Mental Illness and Substance Abuse

Abstract The present study evaluated a model program at Bellevue Hospital Center incorporating a peer-led self-help (PLSH) approach which can be applied to bring about systems-level change in a variety of settings where persons with dual diagnosis are encountered. A total of 461 consecutive MICA inpatient admissions were evaluated to compare the PLSH unit with two standard psychiatric units. The PLSH program was associated with a higher rate of acceptance of aftercare referral (93% vs. 74%) and aftercare attendance (52% vs. 30%) among patients with no prior psychiatric hospitalizations (N = 111). In addition, the PLSH program appeared to benefit chronically impaired MICA patients (N = 350) or those with a history of prior psychiatric hospitalizations, as they were more likely to accept referral to aftercare treatment than were chronic patients discharged from the standard psychiatric units (96% vs. 81%). Such a program, when more widely applied, could yield decreased recidivism and considerably lower medical, psychiatric, and economic cost.
The protective role of general self-determination against ‘thin ideal’ media exposure on women’s body image and eating-related concerns

Women’s responses to ‘thin ideal’ media pending their level of general self-determination (GSD) were examined. High and low GSD women (N = 99) viewed a ‘thin physique salient’ (TPS) video or a ‘thin physique non-salient’ (TPNS) video. Following exposure to the TPS video, perceptions of pressure from the media to be thin, body dissatisfaction, and concerns over quantity of food were greater for low but not high GSD women. However, high GSD women reported greater concerns over the quality of food they eat following exposure to the TPNS video. Prevention efforts aimed at enhancing GSD are discussed.
Cyberknife Treatment for Low and Intermediate Risk Prostate Cancer

Cyberknife is an emerging treatment for early stage prostate cancer. Between October 2012 and January 2014, 32 patients were treated in our institution. Prescribed dose was 35–36.25 Gy in five fractions. Biochemical response was observed in 22 patients. Four patients experienced G2 acute genitourinary toxicity and in two cases we recorded G3 acute GU toxicity. 5 patients experienced G2 acute proctitis. At last follow up visit, all patients were still alive. 29 remained free of disease at last follow up appointment, while three developed a biochemical recurrence. Our experience confirms the efficacy and safety of Cyberknife for localized prostate cancer.
Comparing Consumption: A Curse or a Blessing?

Does it make us unhappier when we compare our current consumption with that of the Joneses or our own past achievements? This paper tries an answer without recurring on interpersonal utility comparisons. It calibrates an economy under three different assumptions, non-comparing utility, and inward-looking and outward-looking habit formation. Using consumption equivalents it then calculates how much individual welfare is affected in each economy by unexpected losses and gains of wealth.
Silibinin Regulates Gene Expression, Production and Secretion of Mucin from Cultured Airway Epithelial Cells

We investigated whether silibinin significantly affects gene expression, production and secretion of mucin from cultured airway epithelial cells. Confluent NCI‐H292 cells were pretreated with silibinin for 30 min and then stimulated with epidermal growth factor (EGF), phorbol 12‐myristate 13‐acetate (PMA) or TNF‐α for 24 h. The MUC5AC mucin gene expression and mucin protein production were measured by reverse transcription–polymerase chain reaction (RT‐PCR) and enzyme‐linked immunosorbent assay (ELISA). The effect of silibinin on TNF‐α‐induced activation of NF‐κB p65 was also examined. Confluent primary rat tracheal surface epithelial (RTSE) cells were pretreated with adenosine triphosphate (ATP) for 5 min and then treated for 30 min in the presence of silibinin to assess the effect on mucin secretion using ELISA. The results were as follows: (i) silibinin inhibited the expression of the MUC5AC mucin gene induced by EGF, PMA or TNF‐α from NCI‐H292 cells; (ii) silibinin also inhibited the production of MUC5AC mucin protein induced by the same inducers from NCI‐H292 cells; (iii) silibinin inhibited the activation of NF‐κB p65 by TNF‐α in NCI‐H292 cells; (iv) silibinin significantly decreased ATP‐induced mucin secretion from cultured RTSE cells. This result suggests that silibinin can regulate gene expression, production and secretion of mucin by directly acting on airway epithelial cells. Copyright © 2012 John Wiley & Sons, Ltd.
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation

Similarities in the phenotypes of mice deficient for cytotoxic T lymphocyte antigen-4 (CTLA-4) or transforming growth factor-β1 (TGF-β1) and other observations have led to speculation that CTLA-4 mediates its inhibitory effect on T cell activation via costimulation of TGF-β production. Here, we examine the role of TGF-β in CTLA-4-mediated inhibition of T cell activation and of CTLA-4 in the regulation of TGF-β production. Activation of AND TCR transgenic mouse T cells with costimulatory receptor-specific antigen presenting cells results in efficient costimulation of proliferation by CD28 ligation and inhibition by CTLA-4 ligation. Neutralizing antibody to TGF-β does not reverse CTLA-4-mediated inhibition. Also, CTLA-4 ligation equally inhibits proliferation of wild-type, TGF-β1−/−, and Smad3−/− T cells. Further, CTLA-4 engagement does not result in the increased production of either latent or active TGF-β by CD4+ T cells. These results indicate that CTLA-4 ligation does not regulate TGF-β production and that CTLA-4-mediated inhibition can occur independently of TGF-β. Collectively, these data demonstrate that CTLA-4 and TGF-β represent distinct mechanisms for regulation of T cell responses.
RELEASE OF MEDIATORS OF ANAPHYLAXIS: INHIBITION OF PROSTAGLANDIN SYNTHESIS AND THE MODIFICATION OF RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS AND HISTAMINE

1 When isolated perfused lungs from sensitized guinea‐pigs were challenged with antigen, histamine, slow reacting substance of anaphylaxis (SRS‐A) and prostaglandin‐like substances were released into the effluent. 2 Treatment of the lungs before and during challenge with indomethacin (0.5–10 μg/ml), sodium aspirin (1–10 μg/ml), sodium meclofenamate (0.1–1 μg/ml) or ketoprofen (0.5–5 μg/ml) inhibited the release of prostaglandins while increasing the output of histamine and SRS‐A between three‐and five‐fold. 3 Diethylcarbamazine (0.2–1 mg/ml) reduced the release of SRS‐A and histamine but increased the amount of prostaglandin‐like substances produced. 4 Eicosatetraynoic acid (10 μg/ml) inhibited formation of prostaglandins but did not modify release of histamine and SRS‐A. 5 The results with non‐steroid anti‐inflammatory drugs and diethylcarbamazine suggest that prostaglandins, or some other product of the cyclo‐oxygenase system, depress the anaphylactic release of SRS‐A and histamine.
Cardiovascular Risk in Clopidogrel-Treated Patients According to Cytochrome P 450 2 C 19 * 2 Loss-of-Function Allele or Proton Pump Inhibitor Coadministration

Results Of the 11,959 patients, carriers of the loss-of-function CYP2C19*2 allele (28% [n 3,418]) displayed a 30% increase in the risk for MACE compared with noncarriers (9.7% vs. 7.8%; OR: 1.29; 95% confidence interval [CI]: 1.12 to 1.49; p 0.001). This single gene variant (CYP2C19*2) was also associated with an excess of mortality (1.8% vs. 1.0%; OR: 1.79; 95% CI: 1.10 to 2.91; p 0.019; n 6,225) and of stent thrombosis (2.9% vs. 0.9%; OR: 3.45; 95% CI: 2.14 to 5.57; p 0.001; n 4,905). This increased risk was apparent in both heterozygotes and homozygotes and was independent of the baseline cardiovascular risk. PPI users (42% [n 19,614]) displayed increased risk for MACE (21.8% vs. 16.7%; OR: 1.41; 95% CI: 1.34 to 1.48; p 0.001) and mortality (12.7% vs. 7.4%; OR: 1.18; 95% CI: 1.07 to 1.30; p 0.001; n 23,977) compared with nonusers. The impact of PPI use was, however, significantly influenced by baseline cardiovascular risk, being significant only in high-risk patients.
PHARMACOLOGICAL SCREENING OF ANTI-OBESITY POTENTIAL OF ACORUS CALAMUS LINN. IN HIGH FAT CAFETERIA DIET FED OBESE RATS

Objective: To study the anti-obesity potential of aqueous rhizome extract of Acoruscalamus Linn. (AREAC)in high fat diet fed obese rats. Methods: Adult strain male Wistar rats used in this study were fed with High Fat Diet (HFD) for 60 days. For the treatment groups,AREAC was administered in a dose levels of100, 200 and 300 mg/kgbw, orally once a day along with HFD. Rats fed with normal pellet chow were served as normal control. The effect of AREAC on physical parameterssuch as body weight, organ weight, fat pad weights and various biochemical parameterslike serum glucose, insulin, leptin,lipid profile, liver markers, kidney markers and oxidative stress markers were analysed. In-vitro pancreatic lipase inhibition assay of AREAC was also studied. Results: Data of in-vivo studies revealedsignificant (p<0.05) reduction in percentage body weight gain, organ weights, fat pad weights and levels of serum glucose, insulin and leptin after treatment with AREAC in a dose dependent manner. Also, administration of AREAC significantly inhibited the increases in the concentrations of triglycerides, total cholesterol, LDL-cholesterol, VLDL-cholesterol, free-fatty acid and phospholipids in a dose dependent manner whereas, the level of HDL-cholesterol was found to be elevated on treatment. Moreover, on treatment with test drug,the elevated levels of serum liver and kidney markerssuch as AST, ALT, ALP, urea, creatinine were also brought back to near normalcy. Antioxidant status was found to be enhanced in liver tissues after treatment. In-vitro studies showed significant inhibition in the activity of pancreatic lipaseby AREAC. Conclusion: The data of the results obtained clearly depicted that AREAC was found to have pronounced anti-obesity activity particularly at the dose levels of 300 mg/kg bw. KeyWords: Obesity, High Fat Diet, Leptin, Acoruscalamus Linn. , Orlistat.
Effect of angle spread on system capacity in DS/CDMA cellular system using adaptive array antenna

This paper evaluates the effect of angle spread on the system capacity for a DS/CDMA system using a delay profile measurement based adaptive array antenna combined with beam pattern selection diversity and carrier-to-interference plus noise (CINR) based transmit power control (TPC) techniques. In the proposed system, beam directivity is controlled by the delay profiles for each terminal measured in each antenna element. Moreover, to reduce the number of computation for the beam directivity control, the proposed system calculates the optimum beam directivity for only a limited number of terminals that locates far from the base station, and signals from the rest of the terminals are demodulated by selecting one of the most reliable adaptive array combined signals. This technique is called beam pattern diversity. For the evaluation of impact of the angle spread of the multipath components on the capacity of DS/CDMA systems with an adaptive array antenna, computer simulation is conducted. The results show that the proposed scheme gives better performance than the sector antenna systems under practical angle spread conditions; i.e. less than 10 degree, with relatively a small number of computation.