Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation-Based Feature Grouping with Decision Tree for Classifying High-Dimentional Imbalanced Data

Classifying high-dimensional imbalanced data is a big challenge in mining real-world big data. Existing algorithms are classifying the majority class instances and get the maximum classification accuracy and minority class instance is overpowered by getting misclassified. In real life applications minority class instances are more significant than the majority class. For classifying imbalanced data sets few techniques based on sampling (Undersampling / over-sampling), cost sensitive learning methods and ensemble learning are used. In our research, A new technique has been introduced, “correlation-based feature grouping with decision tree for classifying highdimensional imbalanced data”. We have assessed the dispatch of the the proposed algorithm on few of the high dimensional imbalanced data sets with different imbalance correspondences. The results are tremendously better to work with high imbalanced data sets. We are devoting this thesis to our parents.
Development of Filipino Nurse Educator’s Wellbeing Survey (FNEWS): An Exploratory Sequential Mixed Methods Study

The role of a nurse educator is a vital component in the management process of teaching and learning development of students. Ensuring excellent wellbeing for nurse educators may lead to increased job satisfaction and work performance. The objective of this study was to develop a survey tool that measures the wellbeing of Filipino nurse educators working in four Gulf Cooperation Council (GCC) countries. Three-phase sequential approach was obtained. The investigation started with a qualitative investigation of 20 Filipino nurse educators based from Saudi Arabia, United Arab Emirates, Oman, and Bahrain followed by a development of survey tool measuring the Filipino nurse educator’s wellbeing. The survey tool was distributed among 112 participants in Saudi Arabia. Data were analyzed and interpreted by means of a Colaizzi method for qualitative and descriptive statistics using SPSS for quantitative measures. All the themes emerged from the qualitative phase were discussed from the gathered review of literature and studies. Themes, contextual categories, and significant statements were used as survey constructs measuring the wellbeing of the participants. Moreover, a valid and reliable survey tool called ‘Filipino Nurse Educator’s Wellbeing Survey’ (FNEWS) was developed and surveyed among the Filipino nurse educators in Saudi Arabia, revealing an ‘acceptable’ level of wellbeing. Knowing the level of wellbeing of nurse educators will be an effective way to provide the competency needed to address burnout, low job satisfaction, and compassion fatigue, thereby increasing the likelihood of safeguarding the welfare of the nurse educators.
Verbal Communication of an Orally Intubated Patient in the Intensive Care Unit: A Case Report.

Background Effective interaction with orally intubated patients is important for critical care rehabilitation. An electrolarynx (EL) has reportedly proven useful for facilitating verbal communication during oral intubation. The EL allows patients to express their wishes instantly. Nevertheless, this method is not commonly applied, probably because articulation is often unsatisfactory. Here, we report a case of successful EL-based communication during early mobilization and describe the key factors involved in this success. Case An 82-year-old man, who was intubated and undergoing mechanical ventilation for the treatment of acute respiratory failure caused by severe pneumonia, was referred to the rehabilitation department for early mobilization. The patient tried to speak during the spontaneous awakening trials and breathing trials for weaning off mechanical ventilation. However, he was frustrated by communication difficulties and consequently exhibited negative behavior toward physical therapy. We attempted to use an EL to facilitate communication, but initially the patient failed to achieve intelligible articulation. We eventually established that the intubation tube should be located at the corner of the mouth to minimize the restriction of tongue movement. Intelligible sounds were recognized and successful communication between the patient and staff was subsequently achieved. Discussion The use of an EL is worthy of consideration during early mobilization of orally intubated patients. To achieve successful communication with an EL, both patient selection (Richmond Agitation-Sedation Scale score of 0 or -1) and the proper placement of the intubation tube are necessary to ensure intelligible articulation.
Effects of citrus latifolia extract on dyslipidemia and tissues redox status in rats fed a high-cholesterol diet

Purpose This study aims to investigate the possible effect of Citrus latifolia (CL) extract on biomarkers of oxidative stress, including lipid peroxidation products in rats fed a high cholesterol diet Design/methodology/approach Hypercholesterolemia was induced by feeding normocholesterolemic rats 1 per cent cholesterol-enriched diet for 15 days. An experimental group (n = 20) was divided into two groups (n = 10) and fed the same diet with or without CL lyophilized aqueous extract (1 per cent) for four weeks. At day 28, ten rats from each group were killed. Findings Treatment with CL lyophilized aqueous extract compared with the untreated group had decreased plasma total cholesterol (TC) (−36 per cent), triacylglycerols (−48 per cent), isoprostanes values (−74 per cent) and reduced thiobarbituric acid reactive substances in erythrocytes (−21 per cent). However, the supplementation of CL peels in the hypercholesterolemic diet enhanced superoxide dismutase (+69 per cent), glutathione reductase (+30 per cent) and catalase activities (+34 per cent). Originality/value In hypercholesterolemic rats, administering CL extract ameliorates dyslipidemia and attenuates lipid peroxidation in tissues. These results suggest that CL could be beneficial in the primary treatment of hypercholesterolemia and oxidative damage caused by a high-cholesterol diet.
Retinal Pigment Epithelium Heating Treatment for Age-Related Macular Degeneration

of the Master’s Thesis Author: Satu Pallasaho Title of the thesis: Retinal Pigment Epithelium Heating Treatment for Age-Related Macular Degeneration Study program: Life Science Technologies Supervisor: Prof. Ari Koskelainen Major or minor/code: Biomedical Engineering / SCI3059 Thesis advisors: M.Sc. Teemu Turunen, M.Sc. Marja Pitkänen Date: 29.7. 2019 Number of pages: 109 + 7 Language: English Age-related macular degeneration (AMD) is a degenerative disease of the retina. The pathogenesis of AMD is not known, but several mechanisms have been proposed. This Master’s thesis introduces theories related to reduced nutrient and oxygen delivery to retina, chronic inflammation, oxidative stress and malfunction of mechanisms maintaining protein homeostasis. Laser heating treatment of the retina is promising treatment modality for AMD. Heating of retina has been observed to induce several changes in the retinal cells. One of the observed changes is the heat shock response. During the heat shock response, cells produce heat shock proteins (HSPs) that maintain protein homeostasis, inhibit the inflammatory response and prevent cell death. Heat shock induction after laser heating may offer a novel therapeutic approach to prevent the progression of AMD. The treatment temperature and duration have to be selected carefully. The temperature needs to be sufficiently high to induce a heat shock response but low enough to prevent cell death. With a longer treatment duration, a lower temperature is needed. This Master’s thesis utilizes electroretinography (ERG) based method to assess retinal temperature during treatment. The purpose of this Master’s thesis was to study how laser heating treatment affects the retinal function in mice. We found substantial variation in power needed to reach the same temperature increase in different mice. This finding supports the usage of temperature determination method during heating treatment. Histological analysis revealed increased HSP expression and signs of cell death within the heated area. The amount of HSP correlated with the used heating laser power.
A Case of Ewing Sarcoma of the Mandible on 18F-FDG PET/CT

Ewing Sarcoma is the second most common type of bone cancer in children. The dominant features of this malignant bone tumor are the tendency for rapid growth and metastasis. In addition, Ewing sarcoma of the mandible is extremely rare and can be mistaken for odontogenic infection. We report a 14-year-old girl who had had swelling, pain, and hypoesthesia in the left cheek for three weeks. She was diagnosed with pericoronitis initially, and then referred toour hospital due to worsening symptoms. CT and MRI revealed an expanding and destructive mass mainly in the left mandible. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and fused PET/CT demonstratedincreased uptake in the mandibular lesion. Whole-body 18F-FDG PET images showed no abnormal activity except for the mandibular lesion. Histologic examination confirmed Ewing sarcoma. Although this tumor has an aggressive clinical behavior and rapid growth, early diagnosis can reduce patient’s morbidity, mortality and thus it is important to distinguish it from periodontal inflammation.
Multisystem vascular disease with successful multisystem percutaneous transcatheter revascularization: Total bodystenting

Patients with diabetes mellitus along other risk factors are vulnerable to develop micro and macro vascular disease including coronary artery, carotid, upper and lower extremities peripheral vascular disease. Physicians dealing with patients with coronary artery disease should at least suspect a disease(s) within other vascular territory or system and vies a versa for this at risk patients. We report a case of 74 year old male patient with history of heavy smoking, chronic obstructive pulmonary disease (COPD), hypertension, diabetes, dyslipidemia, old stroke, chronic renal impairment and chronic anemia. He was referred from another hospital, with history of recurrent, transient ischemic attacks (TIAs), right upper limb and bilateral lower limb claudication, chest pain and three episodes of Non ST elevation Myocardial infarction within the last 2 months. Cardiac catheterization showed multivessel Coronary Artery Disease (CAD), severe occlusive peripheral arterial vascular disease (PAD), in addition to occluded right subclavian and critical bilateral internal carotid artery subtotal stenosis were found and managed successfully with multisystem Percutaneous Transcatheter intervention with near total body stenting.
A Novel Mutation in Human PAX9 Causes Molar Oligodontia

Experimental and animal studies, as well as genetic mutations in man, have indicated that the development of dentition is under the control of several genes. So far, mutations in MSX1 and PAX9 have been associated with dominantly inherited forms of human tooth agenesis that mainly involve posterior teeth. We identified a large kindred with several individuals affected with molar oligodontia that was transmitted as an isolated autosomal-dominant trait. Two-point linkage analysis using DNA from the family and polymorphic marker D14S288 in chromosome 14q12 produced a maximum lod score of 2.29 at Θ = 0.1. Direct sequencing of exons 2 to 4 of PAX9revealed a cytosine insertion mutation at nucleotide 793, leading to a premature termination of translation at aa 315. Our results support the conclusion that molar oligodontia is due to allelic heterogeneity in PAX9, and these data further corroborate the role of PAX9 as an important regulator of molar development.
Direct Conversion of Adult Skin Fibroblasts to Endothelial Cells by Defined Factors

Background—Cell-based therapies to augment endothelial cells (ECs) hold great therapeutic promise. Here, we report a novel approach to generate functional ECs directly from adult fibroblasts. Methods and Results—Eleven candidate genes that are key regulators of endothelial development were selected. Green fluorescent protein (GFP)–negative skin fibroblasts were prepared from Tie2-GFP mice and infected with lentiviruses allowing simultaneous overexpression of all 11 factors. Tie2-GFP+ cells (0.9%), representing Tie2 gene activation, were detected by flow cytometry. Serial stepwise screening revealed 5 key factors (Foxo1, Er71, Klf2, Tal1, and Lmo2) that were required for efficient reprogramming of skin fibroblasts into Tie2-GFP+ cells (4%). This reprogramming strategy did not involve pluripotency induction because neither Oct4 nor Nanog was expressed after 5 key factor transduction. Tie2-GFP+ cells were isolated using fluorescence-activated cell sorting and designated as induced ECs (iECs). iECs exhibited .
Clinical spectrum of dengue at a tertiary care hospital in Eastern India

Background: Dengue is a vector borne disease by four different serotypes of dengue virus transmitted by bite of female Aedes mosquito. It is an acute febrile illness characterised by myalgia, joint pain, gastrointestinal manifestations. Complications like dengue hemorrhagic fever (DHF) and Dengue shock syndrome (DSS) , Extended Dengue Syndrome(EDS) may be fatal for patients. Authors analyse different clinical spectrum of of manifestations, complications and correlation bleeding to platelet level.Methods: This study conducted from July 2017 to December 2018 comprising of 100 dengue patients of age more than 15 years in IMS & SUM Hospital.Result: Out of 100 dengue patients’ males 73% and females 27%. From the patients 57% were NS1 Antigen positive, 29% IgM positive, 9% NS1 and IgM positive, 4% IgM and IgG positive and 2 % with all NS1, IgM, IgG positive. In our series in clinical manifestations, all cases (100%) presented with fever, myalgia (78%), headache (53%), rashes (14%), nausea, pain abdomen (21%) loose motion (17%), and Retro-orbital pain (6%). Bleeding manifestations in any form was seen in 39% cases like Purpura or Petechie (23%), malena (18%), hematemesis ( 2% ), epixtasis (6%), Gum bleeding (2%), Hematuria (1%), and Ophthalmic bleeding like sub conjunctival hemorrhage, intra-vitreal hemorrhage in 8% cases. Complications detected e.g. hepatopathy in 53%, nephropathy. 4%, ascites 8%, pneumonia 7%, DSS (4%), Multi Organ Dysfunction (MODS) (4%), DHF (8%) and EDS in 2% cases. It was observed that 95.8% of patients with platelet counts between 20,000-50,000/cu.mm and 61% of patients less than 25000 had bleeding manifestations.Conclusion: Wide clinical spectrum of manifestations and complications makes it common differential diagnosis of acute febrile illnesses and bleeding manifestation does not always corelate with lower platelet count.
Can coronary computed tomography angiography replace invasive angiography? Yes: it is all about finding the right test for the right person at the right time.

Can stents replace coronary artery bypass surgery? Certainly not. There are some patients with coronary artery lesions that are not amenable to stent placement, there are some patients where stent placement is prognostically inferior to bypass surgery, and there are some situations in which bypass surgery must be used when the attempt to treat a lesion by stent placement failed or resulted in a complication. Does this mean that coronary stents are useless? Certainly not—coronary stents have saved lives and relieved symptoms and continue to do so. They are an alternative to coronary artery bypass surgery in many situations, and they provide a less invasive and economically favorable alternative to open heart surgery. Could we do completely without stenting? Probably we could,1 but the most reasonable approach is to use them when it makes sense. Can coronary computed tomography angiography (coronary CTA) replace invasive angiography? Based on the short introduction, it is probably rather evident what I consider the obvious answer to be: No, coronary CTA cannot entirely replace invasive coronary angiography, but it does not have to to be useful. Could we do completely without coronary CT angiography? Probably we could, but why keep the noninvasive alternative to cardiac catheterization from our patients if there are situations in which a well-performed coronary CTA clearly obviates the need for an invasive angiogram? Response by Stefanini and Windecker on p 417 Let’s take the situation of a 57-year-old female patient I’ll refer to as Betty (even though her true name is different). She reported some rather typical-sounding chest pain on exercise and occasionally at rest. Bicycle stress ECG testing was performed and led to ST–segment depression in the inferior leads (see Figure 1), reproducible on 2 occasions. Her treating cardiologist discussed invasive coronary angiography as the next diagnostic step, with …
Patients’ and General Practitioners’ Views About Preventive Care in Family Medicine in Switzerland: A Cross-sectional Study

Objectives The aim of this study was to describe general practitioners (GPs)’ opinions and practices of preventive care and patients’ opinions, attitudes, and behaviors towards prevention. Methods The data stemmed from a cross-sectional national survey on prevention conducted in Switzerland from 2015 to 2016. In total, 170 randomly drawn GPs and 1154 of their patients participated. The GPs answered an online questionnaire and the patients answered a questionnaire administrated by fieldworkers present at their practices. Results Both patients and GPs agreed that delivering preventive care is the dedicated role of a GP. It appeared that beyond classical topics of prevention such as cardiovascular risk factors, other prevention areas (e.g., cannabis consumption, immunization, occupational risks) were scarcely covered by GPs and reported as little-known by patients. In addition, GPs seemed to use a selective approach to prevention, responding to the clinical context, rather than a systematic approach to health promotion. The results also highlight possibilities to improve prevention in family medicine through options such as more supportive tools and public advertising, more time and more delegated tasks and, finally, a more recognized role. Conclusions Despite an unfavorable context of prevention within the healthcare system, preventive care in family medicine is reasonably good in Switzerland. However, some limitations appear regarding the topics and the circumstances of preventive care delivery. A global effort is needed to implement necessary changes, and the responsibility should be broadened to other stakeholders.
Rare, rarer, rarest: lessons from the largest retrospective study to date on mediastinal sarcomas

Physicians concerned with the diagnosis and management of patients with mediastinal tumors are used to the fact that they have to rely on hardly any secured data and little evidence-based knowledge for their decisions. But even by these standards, primary mediastinal sarcomas are extremely rare tumors that account for no more than 5% of mediastinal neoplasms. Less than 1% of soft tissue sarcomas are located in the mediastinum.
Outlier detection algorithm based on robust component analysis

In outlier detection problem, most existing algorithms have a notable issue that these approaches cannot detect highdimension outliers effectively. In order to provide a practical solution for this problem, we propose an outlier detection algorithm based on robust component analysis. The basic idea is to train multiple base detectors with the robust component analysis results of the training dataset. Furthermore, we generate some virtual outliers and utilize them to test the capacities of based detectors, and combine them according to the test results to obtain the final outlier detector. Experimental results comparing the proposed method with baseline approaches are presented on several datasets showing the performance of our approach.
What affects length of hospital stay? A case study from Malta.

PURPOSE Hospital length of stay (LOS) is not only a function of patient- and disease-related factors, but is also determined by other health system-wide variables. Managers and clinicians strive to achieve the best possible trade-off between patients' needs and efficient utilisation of hospital resources, while also embracing ethical decision making. The purpose of this paper is to explore the perceptions of the hospital's major stakeholders as to what affects the duration of LOS of inpatients. DESIGN/METHODOLOGY/APPROACH Using a data-triangulated case study approach, 50 semi-structured interviews were performed with management, doctors, nurses and patients. Additionally, the hospitals' standard operating procedures, which are pertinent to the subject, were also included in the thematic analysis. FINDINGS This study shows that LOS is a multi-dimensional construct, which results from a complex interplay of various inputs, processes and outcomes. RESEARCH LIMITATIONS/IMPLICATIONS The findings emerging from a single case study approach cannot be generalised across settings and contexts, albeit being in line with the current literature. PRACTICAL IMPLICATIONS The study concludes that a robust hospital strategy, which addresses deficient organisational processes that may unnecessarily prolong LOS, is needed. Moreover, the hospital's strategy must be sustained by providing good primary care facilities within the community set-up, as well as by providing more long-term care and rehabilitation beds to support the hospital turnover. ORIGINALITY/VALUE The subject of LOS in hospitals has so far been tackled in a fragmented manner. This paper provides a comprehensive and triangulated account of the complexities surrounding the duration in which patients are kept in hospital by key stakeholders, most of whom were hands-on in the day-to-day running of the hospital under study.