Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term outcomes of monocanalicular lacrimal stenting in punctum and canalicular stenosis or obstruction

ABSTRACT Background: Morbid epiphora may occur in stenosis or obstruction (S/O) of proximal lacrimal system. Our study aimed to determine the role of monocanalicular lacrimal stents in the management of punctum and canalicular S/O. Research design and methods: A retrospective, single-surgeon based review of patients who underwent punctum and canalicular dilatation, recanalisation and monocanalicular stenting, were enrolled. The stent was kept in-situ for 6–8 weeks in all. Both subjective (relief from epiphora) and objective (fluorescein dye disappearance test) outcomes were recorded. Results: Forty-four puncta and 53 canaliculi had S/O. At mean followup of 13.5 months, complete relief was reported by 37(84.09%) and 42(79.25%) eyes of punctum and canalicular S/O, respectively, while 1(2.27%) and 6(11.32%) eyes had no relief. Spontaneous stent extrusion occurred in total 10(10.31%) eyes. Conclusion: Monocanalicular lacrimal stent is a safe, user-friendly and clinically effective tool in the long-term management of punctum and canalicular stenosis or obstruction.
Chlor-amidine, a novel PAD inhibitor, as an effective drug for the treatment of ulcerative colitis and prevention of colorectal cancer

Protein arginine deiminases (PADs) are a family of enzymes that catalyze citrullination, the post-translational conversion of peptidyl-arginine to peptidyl-citrulline. The resulting shift from the neutral arginine to the positive citrulline can interrupt hydrogen bond formation and protein-protein interactions with consequential effects on protein function. PADs and citrullination are associated with the regulation of genes and apoptosis under physiological conditions; however, elevated levels of citrullinated proteins are implicated in the initiation and progression of many inflammatory diseases, including ulcerative colitis and various cancers. Due to the involvement of PADs in many pathological conditions, PAD inhibitors have been developed to prevent and treat abnormal PAD activity. One such small molecule inhibitor of PADs, Cl-amidine, targets the four active isozymes of PADs by covalent modification of the active site of the enzymes. Our previous in vitro studies using microarray analysis of miRNAs revealed that only a small subset of miRNAs are affected by Cl-amidine, instead of global miRNA regulation. The most significantly upregulated miRNA by Cl-amidine was miR-16, a putative tumor suppressor miRNA with cell cycle targets. The aim of our current study is to understand how Cl-amidine is targeting select miRNAs, like miR-16. One hypothesis explores the epigenetic regulation of miRNAs, specifically by methylation-mediated gene silencing. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), a family of enzymes
A Health Psychology Perspective on the Recent Medical Literature of Cardiovascular Disease

New blood pressure guidelines publicized last spring (Chobanian et al., 2003) made waves in the national media. A panel of experts convened by the National Heart, Lung, and Blood Institute determined that blood pressure readings as low as 120 over 80, long thought to be a healthy level, actually represent “prehypertension. ” In addition to the 50 million Americans already estimated to have high blood pressure, 45 million more are now considered at increased risk for cardiovascular diseases and premature death.
Prevalence of Klebsiella in urinary tract infection among pregnant women from South India

Introduction: One of the frequently seen complications in pregnancy is urinary tract infection. Other complications like acute and chronic pyelonephritis, hypertension, intrauterine growth retardation occur due to UTI. Early detection and treatment of bacteria helps in the prevention of chronic urinary disease in the community and to avoid complications in pregnancy at an early stage. In view of the above an attempt was made to isolate and identify the Klebsiella pathogens from urine in suspected cases of UTI in pregnant women. Materials and Methods: A total of 500 samples were investigated. The samples were collected from women attending the antenatal clinic at the Khaja Banda Nawaz Hospital, Gulbarga. A proforma was used to collect the data from the subjects of varying ages from 18 to 40 years, from varying gravida and all three trimesters were included. Sterilized urine container was used to collect urine with all aseptic precautions. Macroscopic and microscopic examination was done. Culture and biochemical reactions were done and the strains were isolated and identified. Results: 52 women were found to be suffering from UTI, giving a prevalence rate of 10.4% (52/500). The incidence of organisms isolated in bacteriuric cases showed Klebsiella as the major isolate constituting 25%. Conclusion: Urinary tract infection the most commonly seen complication in pregnancy. Both Gram-negative and Gram-positive bacteria were isolated. Klebsiella organism was isolated more commonly than other organisms in UTI in pregnant women.
An Improved Denoising of Medical Images Based on Hybrid Filter Approach and Assess Quality Metrics

Degradation of images and segmentation are the two most demanding fields for medical image processing, particularly when explicitly applied. The involvement of noise not only deteriorates the visual quality but also the precision of the segmentation which is vital to the medical diagnosis process of development. The complicated and monotonous main task is to manually denoise medical images such as CT, ultrasound and large numbers of clinical routine MRI images. The medical image must be denoised automatically. The proposed approach is associated with less complexity, this follows from the fact that, the design of system and time for optimization. Results show their efficacy for noise removal in medical ultrasound and MRI images . The final results of the proposed scheme in terms of noise reduction and structural preservation are excellent. However the proposed scheme is compared with existing methods and the performance of the proposed method in terms of visual quality, image quality index, peak SNR and PSNR is shown to be superior to existing methods.
A Simulation Study on the Impact of InP Barrier on InGaAs/InP Hetero Junction Gate all around MOSFET

In this work, we have analyzed the digital and analog performance for InGaAs/InP heterojunction Gate all around MOS structure. A detailed study on the impact of Barrier thickness on different analog and digital performance for an InGaAs/InP hetero structure GAA MOSFET is carried out by using TCAD device simulation. The electrical parameters such as surface potential, electric field, transfer characteristics, output characteristics, transconductance and output conductance is carried out and analyzed by varying the barrier thickness from 1 nm to 4 nm. Based on the simulation results it is investigated that the effect of the all electrical parameters in the nanoscale devices. It has been seen from the presented results that the influence of barrier thickness variation gives the notable improvement in drain current. The impact of InGaAs/InP hetero structure and barrier thickness variation claims GAA MOSFET as a promising candidate for VLSI applications. Keywords: Heterojunction, InGaAs/InP, TCAD, Analog parameters.
Selected novel aspects in pathogenesis of lupus erythematosus – interdisciplinary view

Lupus erythematosus is an autoimmune disease characterized by complex immune disturbances concerning humoral and cell-mediated immune responses. Despite intensive research, many pathological processes regarding this disorder remain unexplained. During interdisciplinary investigations on the etiology of lupus and its complications special interest has recently been referred to heat-shock proteins, antibodies directed against such proteins and galectin-3. These issues are extensively studied not only by dermatologists and rheumatologists, but also by cardiologists (in terms of cardiovascular complications) and nephrologists (in terms of lupus nephritis). This study presents the current state of dermatological, nephrological and cardiological knowledge on this topic. Wybrane nowe aspekty patogenezy tocznia rumieniowatego – spojrzenie interdyscyplinarne Selected novel aspects in pathogenesis of lupus erythematosus – interdisciplinary view Agnieszka Kalińska-bienias1, bartosz Foroncewicz2, Piotr bienias3, cezary Kowalewski1 1Klinika Dermatologii i Immunodermatologii Warszawskiego Uniwersytetu Medycznego 2Klinika Immunologii, Transplantologii i Chorób Wewnętrznych Instytutu Transplantologii Warszawskiego Uniwersytetu Medycznego 3Klinika Chorób Wewnętrznych i Kardiologii Warszawskiego Uniwersytetu Medycznego Przegl Dermatol 2016, 103, 345–353 DOI: 10.5114/dr.2016. 62884 SłoWA KluczoWe: toczeń rumieniowaty skórny, toczeń rumieniowaty układowy, białka szoku termicznego, galektyna 3, patogeneza. Key WordS: cutaneous lupus erythematosus, systemic lupus erythematosus, heat-shock proteins, galectin-3, pathogenesis. AdreS do KoreSPondencji: Agnieszka Kalińska-Bienias Klinika Dermatologii i Immunodermatologii Warszawski Uniwersytet Medyczny ul. Koszykowa 82A 02-008 Warszawa tel. : +48 606 618 564 e-mail: agnieszka.kalinska@ interia.pl
EPOWT: A denoising technique of the electrocardiography signal transmission via 5G wireless communications

This article provides a thorough review of 5G wireless electrocardiography (ECG) communication for actual cardiac signal using both technical and clinical features for the purpose of recommending real‐time observation. Major issue regarding this frame work is the distortion and smoothness of ECG signal for the cardiologist advice also it needs correct diagnosis at the proper time. Extensive 5G wireless simulated scenarios are used to supervise the compressed ECG signal on reception. An efficient ECG transmission protocol is a modern and consistent ECG transmission protocol which is used to retransmit the noise signals. Thus, we are filtering the ECG signals to improve the quality which may directly affects the medical diagnosis. Because, time and frequency indicators can be obtained by the wavelet analysis but majority of the error functions cannot be flexible to various signals because of the static transition curve of threshold. Hence, we proposed a new emperor penguin optimization (EPO) together with wavelet thresholding (EPOWT) method. Here, the EPOWT is estimated through the means of real‐time ECG records. The outcomes of filtering process shows that the proposed EPOWT approach can achieve smooth threshold transition and soft thresholding bring the wavelet coefficient. EPOEPO algorithm is used to improve its flexibility to different signals. The EPOWT can generate an essential noise‐free signal by balancing the smoothness and signal distortion filtering for transmission. The proposed method can attains 2.9 seconds delay during simulation. Thus, the 5G wireless channel parameter's functioning zone is simple to acquire.
Epidemiology study of never-smokers with non-small cell lung cancer (NSCLC): High percentages of Asian and Hispanic female never-smokers and the significance of Asian ethnicity

8004 Background: Never-smokers with non-small cell lung cancer (NSCLC) have unique epidemiologic features and survival outcome. Methods: This retrospective population-based study of never-smokers with NSCLC involves analysis of NSCLC cases from the Cancer Surveillance Programs of three Southern California counties from 1991 to 2005. Results: 25,204 NSCLC patients with known smoking status were analyzed. 2240 patients (8.9%) were never-smokers. More females, more adenocarcinoma, approximately 3-fold more bronchioloalveolar carcinoma (BAC), and more distant disease were found among never-smokers. Median age of presentation was higher for never-smokers (vs. smokers; 71 vs. 69 years; P < .0001). Overall survival (OS) (P < .0001) and lung cancer-specific survival (LCSS) (P < .0001) in never-smokers were significantly improved over smokers. Never-smokers with distant disease (8 months OS improvement) benefited more from chemotherapy than smokers (6 months OS improvement). By multivariate analysis smoking status.
Virtuele realiteit en audiovisuele afleiding als methoden van pijnbestrijding bij medische procedures : mogelijkheden en beperkingen

This review focuses on Virtual Reality (VR) and Audiovisual eye-glass systems (Av distraction) as adjunct analgesic techniques during painful medical procedures. Both techniques make use of advanced audiovisual technology, often combined with tactile stimulation and haptic feedback. It is assumed that this kind of stimulation taxes the patient's limited attention capacity and reduces the capacity to process the noxious stimulus, resulting in pain reduction. The results of eighteen studies applying VR or Av distraction in six different patient groups and in healthy volunteers in two experimental setting are evaluated and discussed. In spite of several serious methodological drawbacks, the majority of the studies nevertheless suggest that both techniques appear to be a promising analgesic method that can be applied safely, effectively and without any serious side effects to reduce pain and discomfort during medical procedures. Practical aspects of VR and Av distraction in the clinical setting are discussed and recommendations for future research are given.
Research on Medical Image Encryption Method Based on Improved Krill Herb Algorithm and Chaotic Systems

Based on chaotic system and improved krill herb algo-rithm, so password ﬂow is generated, and we put forward an eﬀective medical image encryption method in this paper. The new method adopts adaptive function to sort krill individuals and select the best results. The output sequence of sub-key formed by location of part of individual encrypts medical image. Experimental results show that the new algorithm is more complexity and randomness than ordinary pseudo-random sequence generator. It limits the possibility of inferring all keys by attacker, and ensures the eﬀectiveness of resistance in known plaintext attack. Finally, it achieves high security of encryption for medical images compared with other encryption methods.
Scientific Opinion on Rooster Combs Extract

Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to carry out the additional assessment for „Rooster Combs Extract‟ (RCE) as a food ingredient in the context of Regulation (EC) No 258/97, taking into account the comments and objections of a scientific nature raised by Member States. Rooster combs extract results from a production process involving enzymatic hydrolysis of rooster combs and subsequent filtration, concentration and precipitation steps. The principle constituents of RCE are the glycosaminoglycans hyaluronic acid, chondroitin sulphate A and dermatan sulphate. The applicant intends to add RCE to a number of dairy products with a recommended maximum intake of 80 mg RCE per portion and per day. The target population is the general population, with the exception of pregnant women, children and people with adverse reactions to sodium hyaluronate and/or avian protein. In the high intake scenario for “consumers only”, the highest daily intake would occur in adults in Belgium (0.788 g). The highest intake scenario for “all subjects” was estimated for adolescents in Denmark (0.427 g/day). The Panel notes that no adverse effects were observed at the highest tested dose of 600 mg/kg bw per day in a 90-day oral toxicity study in rats. Considering the nature, the natural occurrence and previous consumption of RCE constituents, the Panel is of the opinion that the margin between the intended as well as the estimated maximum possible intake of RCE in relation to the highest dose administered to rats without adverse effects in a subchronic oral toxicity study is sufficient. The Panel concludes that the novel food ingredient, Rooster Comb Extract, is safe under the proposed uses and use levels. © European Food Safety Authority, 2013
SAT0592 Peak-Incidence Age in Rheumatoid Arthritis Has Not Shifted in Finland since The Turn of Millennium

Background Over the recent decades several studies have observed a shift towards higher age at disease onset in the incidence of rheumatoid arthritis (RA). The cause of this phenomenon is unknown. Objectives To find out whether the peak-incidence age has still been increasing during this millennium. Methods From the nationwide drug reimbursement register maintained by the Finnish Social Insurance Institution we collected data on all patients with incident inflammatory rheumatic diseases from January 1st 2000 to December 31st 2014. Patients with incident RA were identified by the ICD-10 codes of M05 and M06. The peak-incidence age of this cohort was modelled using the Poisson regression with restricted cubic splines (5 knots). Results During the observation time altogether 27 764 patients (mean age 61.3 at disease onset, 67.5% female) with a new diagnosis of RA were identified. Table shows the peak-incidence ages as well as mean ages at disease onset during the whole observation time and by 3-year periods. The peak-incidence age remained stable over the 15 years since the turn of millennium. The mean age at disease onset increased slightly in male. Period All Female Male Peak-incidence age Peak-incidence age Mean age at RA onset (SD)* Peak-incidence age Mean age at RA onset (SD)** 2000–14 69 67 70 2000–02 69 68 56.6 (15.3) 70 57.7 (13.2) 2003–05 68 66 56.8 (14.9) 70 58.5 (12.7) 2006–08 68 67 56.5 (15.8) 68 59.1 (12.7) 2009–11 68 66 56.8 (15.2) 70 58.8 (13.4.) 2012–14 70 69 57.1 (15.8) 71 59.9 (13.5) *p=0.71; **p=0.001 for linearity of the trend in mean age at RA onset. Conclusions These results suggest that the unknown factors in the population and environment behind the earlier observed shift towards higher age in the incidence of RA have no longer been gaining power during the 21th century. Disclosure of Interest None declared
Application of Novel Gabor-DCNN into RGB-D Face Recognition

In this paper, we propose a novel approach, named Gabor-DCNN, applied for face recognition technology of two modalities RGB-D images, which can extract the features through Gabor transform of images and deep convolutional neural network. Gabor transform can capture the salient visual properties with spatial frequencies and lo-cal structural features of diﬀerent directions in a local area of images and enhance the object representation capability. Deep convolutional neural networks could automatically learn essential features from images compared with traditional methods. The most signiﬁcant features can be obtained through the Gabor-DCNN. The ﬁnal features expression of the face is performed by feature fusion of two modalities images. The experimental results indicate that the algorithm achieves much better performance than some state-of-the-art methods in terms of recognition rates on the EURECOM data set. This research provides an eﬀective method for multiple modal face recognition under complex conditions.
Anonymous Transaction of Digital Currency Based on Blockchain

Blockchain can be seen as a shared database, and keep all data public and traceable. Everyone is accessible to the data recorded on the blockchain, which brings the risk of privacy leakage. When digital currency transactions are performed on the blockchain, users may not want to reveal their real identities. Therefore, it is particularly important to preserve the identity privacy of users. To solve the problem, we present an anonymous transaction scheme of digital currency to ensure the anonymity of the sender and receiver. we design a linkable ring signature algorithm based on elliptic curve cryptography (ECC) to conceal the real identity of sender and check double-spending. It is intermediate address that is used for concealing the real identity of receiver. Furthermore, we utilize a agency to reduce computational burden for receiver. Throughout the transaction process, the real identities of two sides are not disclosed to others, ensuring anonymous transaction.
Identity Based Key-Insulated Encryption with Outsourced Equality Test

We ﬁrstly combine the concepts of key-insulated encryption (KIE) and identity-based encryption with the equality test (IBE-ET) to obtain identity-based key-insulated encryption with equality test (IB-KIEET). The scheme inherits the advantages of identity-based encryption (IBE), which simplifying certiﬁcate management for public key encryption. Furthermore, the key-insulated mechanism was added in our scheme, which perfectly reduced the possibility of key exposure. Our scheme achieves weak indistinquishable identity chosen ciphertext (W-IND-ID-CCA) security in the random oracle model. Meanwhile, it is indicated that our scheme is feasible and practical through the experimental simulation and theoretical analysis.
The Complex Relation between Executive Functions and Language in Preschoolers with Developmental Language Disorders

Backgrounds: The relationship between linguistic difficulties and cognitive impairments in children with developmental language disorders (DLDs) is receiving growing interest in international research. Executive functions (EF) appear to be weak in these children. The current investigation aims at exploring the relationship between difficulties in two components of EF (i.e., updating and inhibition) and the linguistic and narrative skills of 16 DLD preschoolers matched with 24 typically developing peers. Methods: Updating skills were tested by administering the forward and backward digit recall subtests of the Wechsler Scales, while children’s inhibition abilities were assessed by completion of Developmental Neuropsychological Assessment (NEPSY-II) inhibition tasks. Information on the linguistic skills of the participants was collected through a set of subtests included in the Batteria per la Valutazione del Linguaggio in bambini dai 4 ai 12 anni (Batteria per la Valutazione del Linguaggio; BVL_4-12), assessing articulatory and phonological discrimination skills, lexical production/comprehension, grammatical production/comprehension, and narrative production skills. Results: Findings revealed that DLD children performed significantly lower than their peers on both updating and inhibitory tasks. Linguistic difficulties were found in the DLD group on articulatory/phonological skills, grammatical production/comprehension, and lexical informativeness on narrative production. Measures of EF correlated with linguistic and narrative measures. Conclusion: The current study confirms a significant association between DLD’s performances on EF and displayed linguistic skills, suggesting the need to include the assessment of executive functions to target early intervention rehabilitation programs for children with DLDs.