Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction.

BACKGROUND Despite the widespread use of intravenous thrombolytic therapy and of immediate percutaneous transluminal coronary angioplasty for the treatment of acute myocardial infarction, randomized comparisons of the two approaches to reperfusion are lacking. We report the results of a prospective, randomized trial comparing immediate coronary angioplasty (without previous thrombolytic therapy) with intravenous streptokinase treatment. METHODS A total of 142 patients with acute myocardial infarction were randomly assigned to receive one of the two treatments. The left ventricular ejection fraction was measured by radionuclide scanning before hospital discharge. Quantitative coronary angiography was performed to assess the degree of residual stenosis in the infarct-related arteries. RESULTS A total of 72 patients were assigned to receive streptokinase and 70 patients to undergo immediate angioplasty. Angioplasty was technically successful in 64 of the 65 patients who underwent the procedure. Infarction recurred in nine patients assigned to receive streptokinase, but in none of those assigned to receive angioplasty (P = 0.003). Fourteen patients in the streptokinase group had unstable angina after their infarction, but only four in the angioplasty group (P = 0.02). The mean (+/- SD) left ventricular ejection fraction as measured before discharge was 45 +/- 12 percent in the streptokinase group and 51 +/- 11 percent in the angioplasty group (P = 0.004). The infarct-related artery was patent in 68 percent of the patients in the streptokinase group and 91 percent of those in the angioplasty group (P = 0.001). Quantitative coronary angiography revealed stenosis of 36 +/- 20 percent of the luminal diameter in the angioplasty group, as compared with 76 +/- 19 percent in the streptokinase group (P < 0.001). CONCLUSIONS Immediate angioplasty after acute myocardial infarction was associated with a higher rate of patency of the infarct-related artery, a less severe residual stenotic lesion, better left ventricular function, and less recurrent myocardial ischemia and infarction than was intravenous streptokinase.
Multifunctional copolymer coating of polyethylene glycol, glycidyl methacrylate, and REDV to enhance the selectivity of endothelial cells

Multifunctional polymer coatings have potential applications in biomaterials. These coatings possess reactive functional groups for the immobilization of specific biological factors that can influence cellular behavior. These coatings also display low nonspecific protein adsorption. In this study, we prepared a multifunctional polymer coating through the deposition of random copolymers of poly(ethylene glycol) methacrylate (PEGMA) and glycidyl methacrylate (GMA) to prevent nonspecific attachment and enable the covalence of Arg–Glu–Asp–Val (REDV) peptide with endothelial cells (ECs) selectivity. Coatings were characterized by X-ray photoelectron spectroscopy (XPS). The adhesion and proliferation of ECs and smooth muscle cells (SMCs) onto the REDV-modified surface were investigated to understand the synergistic action of antifouling PEG and EC selective REDV peptide conjugated GMA. The copolymers containing GMA and PEG groups are very useful as a multifunctional coating material with anti-fouling and ECs specific adhesion for implant materials surface modification.
Fungi associated with pods and seeds during the R6 and R8 stages of four soybean cultivars in southwestern Indiana.

Un total de 6403 isolats de champignons ont ete recuperes de gousses et de graines de soja recoltees vers la fin des saisons 1992 et 1993 (stades de croissance R6 et R8). La majorite des champignons etaient des Deuteromycetes (95,5 %) puis des Ascomycetes (0,9 %). Les genres de champignons les plus communement isoles lors de l’etude furent les Phomopsis, Alternaria, Cercospora, et Colletotrichum (= Glomerella). Les Cercospora et les Phomopsis ont ete retrouves plus souvent sur les gousses et les graines a pleine maturite (R8) qu’au stade de developpement feve verte (R6). Par contre, la frequence d’isolement des Colletotrichum etait plus elevee pour les tissus recoltes au stade R6 que pour ceux au stade R8. Les frequences d’isolement etaient similaires pour les tissus des gousses ou des graines pour la plupart des champignons sauf les Alternaria, Phoma et Nigrospora. Les principales especes pathogenes isolees du complexe Diaporthe/Phomopsis etaient le D. phaseolorum var. caulivora et le D. phaseolorum var. sojae avec des frequences d’isolement totalisant 28,2 % alors que le D. phaseolorum var. meridionalis et le Phomopsis longicolla etaient identifies dans 1 % de tous les echantillons. Dans cette etude, les tissus des gousses contenaient un plus grand nombre de champignons que les graines. Des comparaisons statistiques des sections du pedoncule, du centre et du style des gousses n’ont pas permis de trouver de difference entre les frequences d’isolement pour les cultivars testes, que ce soient les tissus des gousses ou les graines qui soient compares. En resume, la frequence d’isolement de champignons pathogenes de gousses et de graines au stade R6 a ete un indicateur fiable du potentiel de gravite des maladies. De plus, la presence significativement plus grande du D. phaseolorum var. caulivora et du D. phaseolorum var. sojae par rapport aux autres Phomopsis/ Diaporthe spp. (e.g. D. phaseolorum var. meridionalis) dans le sud-ouest de l’Indiana va permettre aux scientifiques de continuer a concentrer leurs efforts d’amelioration genetique sur la resistance a ces deux importants agents pathogenes.
Vermetid Gastropods and Intertidal Reefs in Israel and Bermuda

Small-rimmed intertidal reefs develop in the subtropical marine waters of Israel and Bermuda when erosion of exposed promontories is arrested by vermetid gastropods. The reefs in Bermuda are actively growing, wave-resistant biogenic structures, while those in Israel are limestone structures only encrusted by a relatively thin layer of vermetid shells cemented by coralline algae.
Combination chemotherapy with gemcitabine and vinorelbine in the treatment of relapsed or refractory diffuse large B‐cell lymphoma: a phase‐II trial by the Hellenic Cooperative Oncology Group

Abstract: To investigate the efficacy and toxicity of the combination of gemcitabine and vinorelbine in patients with relapsed or refractory diffuse large B‐cell lymphoma (DLBL), 22 patients with relapsed or refractory DLBL were treated with gemcitabine 1000 mg/m2 and vinorelbine 30 mg/m2 on days 1 and 8 every 3 wk for a maximum of six cycles. Fourteen patients were considered chemosensitive while eight patients were considered chemoresistant to the last treatment regimen. All 22 patients were assessed for response to treatment. Three patients (14%) achieved complete remission and eight patients (36%) had partial remission of their disease, with an overall response rate of 50%. With a median follow up of 44 months, the median time to progression (TTP) for all patients was 8.1 months while the median overall survival (OS) was 12.9 months. Toxicity was minimal and all patients were treated on an outpatient basis. The combination of gemcitabine and vinorelbine is an effective and well‐tolerated regimen for patients with relapsed of refractory DLBL.
α-Klotho as a Regulator of Calcium Homeostasis

α-klotho was identified as a gene associated with premature aging–like phenotypes characterized by short lifespan. In mice, we found the molecular association of α-Klotho (α-Kl) and Na+,K+-adenosine triphosphatase (Na+,K+-ATPase) and provide evidence for an increase of abundance of Na+,K+-ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca2+]e) rapidly induce regulated parathyroid hormone (PTH) secretion in an α-Kl- and Na+,K+-ATPase–dependent manner. The increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of α-Kl in the regulation of calcium metabolism.
LDPC decoding for CMMB utilizing OpenMP and CUDA parallelization

As the 4G mobile communication systems require high transmission rate with reliability, the demand for efficient error correcting code increases. In this paper, a novel LDPC (Low Density Parity Check) decoding method is introduced. We address a parallel software implementation of LDPC decoding for CMMB (China Multimedia Mobile Broadcasting) standard. LDPC codes for CMMB employ a regular H-matrix which has the fixed row and column weights. While effectively utilizing the regularity of the H-matrix, we process information on H-matrices for multiple code rates using OpenMP pragmas on a multi-core processor and execute the decoding algorithm in parallel using CUDA (Compute Unified Device Architecture) on a GPU (Graphics Processing Unit). We evaluated the performance of the proposed implementation with respect to two different code rates, and verified that the proposed implementation satisfies the bandwidth requirement for CMMB.
Sequential therapy for Helicobacter pylori: time to consider making the switch?

HELICOBACTER PYLORI INFECTION REMAINS AN IMportant cause of morbidity and mortality worldwide. Attempts at developing a vaccine have failed, and the current focus for clinicians is the treatment of the infection. Eradication of H pylori has been shown to prevent recurrent peptic ulcer disease, to cure some localized gastric mucosa–associated lymphoid tissue lymphomas, and to prevent nonsteroidal anti-inflammatory drug (NSAID)–related ulcers in patients who are initiating longterm NSAID therapy. In recent years, the rate of treatment failure associated with established drug regimens has increased at a rapid rate.
An analysis of the end‐plate potential recorded with an intra‐cellular electrode

According to present knowledge, the process of neuromuscular transmission can be described by the following scheme: nerve impulse -+ acetylcholine -end-plate potential -* muscle impulse -* contraction. The evidence for this chain has been summarized by Eccles (1948), Hunt & Kuffler (1950) and Rosenblueth (1950), whose reviews may be consulted for further references. While there is little doubt that acetylcholine is released by the nerve impulse and depolarizes the end-plate, the mechanism of these two actions is at present unknown and requires further investigation. The most immediate electrical sign of neuromuscular transmission is the end-plate potential, a local depolarization of the muscle fibre which is presumably due to the direct action of the neuromuscular transmitter. By measuring this electrical change under suitable conditions, some light can be thrown on the preceding steps of the transmission process. The object of this paper is to investigate the properties ofthe end-plate potential even more closely than has previously been attempted, making use of the method of intra-cellular recording which has been developed by Graham & Gerard (1946), Ling & Gerard (1949) and Nastuk & Hodgkin (1950). This method offers several advantages: resting and action potentials at individual junctions can be recorded in whole muscles, without microdisection or even removing the muscle from a Ringer bath, and the measurements do not suffer from uncertainties which are usually associated with the shunting effect of the interstitial fluid. The immediate concern of the present work is to determine the electric charge which passes through the end-plate membrane during the transmission of one impulse and to throw some light on the mechanism by which the transfer of ions across the end-plate is brought about.
Is screening for cervical cancer effective?

Screening for cervical cancer certainly satisfies the first two criteria. There is usually a long latent period in which dysplastic change, which precedes cancer, can be detected. Treatment for dysplasia is effective, as is that for early cervical cancer. The costeffectiveness of cervical screening is debatable but this is a political issue. By 1997 it was estimated that in the UK screening was saving the lives of 800 women annually at a cost of £124 million per year [1].
Control of a power assist robot for lifting objects based on human operator's perception of object weight

An object lifted with a power assist robot is always perceived lighter than its actual weight. But, the human operator cannot differentiate between the power assisted weight and the actual weight and eventually applies load force (vertical lifting force) according to the actual weight of the object. This faulty force programming (excessive load force) gives faulty motions to the power assist robot and jeopardizes its operability, maneuverability, ease of use, naturalness, human-friendliness, safety etc. In this paper we assume that these problems still exist with the power assist robots because human's weight perception is not included in the design and control of the conventional power assist robots . We hypothesize that human's perception of weight due to inertial force may be different from the perceived weight due to gravitational force for lifting object with a power assist robot. Based on this hypothesis, we designed a 1 DOF power assist robot and established a psychophysical relationship between the actual weights and the power assisted weights for the objects lifted with the robot. We also determined the excess of the load forces that humans applied. Then, we modified the control system of the power assist robot based on the psychophysical relationship and the load force characteristics. The modification of the control system reduced the peak load forces applied by humans and thus enhanced maneuverability, naturalness, ease of use, stability, safety etc. of the robot system significantly. Finally, we proposed using the findings to design human-friendly power assist robots for carrying heavy objects in various industries.
A Comprehensive Study on Cloud Computing

Cloud computing is becoming an increasingly popular enterprise model in which computing resources are made available on-demand to the user as needed. The unique value proposition of cloud computing creates new opportunities to align IT and business goals. Cloud computing use the internet technologies for delivery of IT- Enabled capabilities 'as a service' to any needed users i.e. through cloud computing we can access anything that we want from anywhere to any computer without worrying about anything like about their storage, cost, management and so on. In this paper we provide a comprehensive study on the motivation factors of adopting cloud computing, review the several cloud deployment and service models. It also explore certain benefits of cloud computing over traditional IT service environment-including scalability, flexibility, reduced capital and higher resource utilization - are considered as adoption reasons for cloud computing environment. We also include security, privacy, internet dependency and availability as avoidance issues. The later includes vertical scalability as technical challenge in cloud environment.
Review article: cytochrome P450 and the metabolism of proton pump inhibitors — emphasis on rabeprazole

The proton pump inhibitors rabeprazole, omeprazole, lansoprazole, and pantoprazole undergo an extensive hepatic biotransformation. In the liver, they are metabolized to varying degree by several cytochrome P450 (CYP) isoenzymes which are further categorized into subfamilies of related polymorphic gene products. The principal isoenzymes involved in the metabolism of proton pump inhibitors are CYP2C19 and CYP3A4. Of these two, minor mutations in CYP2C19 affect its activity in the liver and, in turn, the metabolic and pharmacokinetic profiles of the proton pump inhibitors. The metabolism of rabeprazole is less dependent on CYP2C19 and therefore is the least affected by this genetic polymorphism. Recent studies have brought to light the important role that this polymorphism plays in the therapeutic effectiveness of proton pump inhibitors during the treatment of acid‐related diseases.
Regulation of cholesterol efflux from macrophages

Purpose of review The lipid efflux pathway is important for both HDL formation and the reverse cholesterol transport pathway. This review is focused on recent findings on the mechanism of lipid efflux and its regulation, particularly in macrophages. Recent findings Significant progress has been made on understanding the sequence of events that accompany the interaction of apolipoproteins A–I with cell surface ATP-binding cassette transporter A1 and its subsequent lipidation. Continued research on the regulation of ATP-binding cassette transporter A1 and ATP-binding cassette transporter G1 expression and traffic has also generated new paradigms for the control of lipid efflux from macrophages and its contribution to reverse cholesterol transport. In addition, the mobilization of cholesteryl esters from lipid droplets represents a new step in the control of cholesterol efflux. Summary The synergy between lipid transporters is a work in progress, but its importance in reverse cholesterol transport is clear. The regulation of efflux implies both the regulation of relevant transporters and the cellular trafficking of cholesterol.
THE EPIDEMIC JAUNDICE OF CAMPAIGNS

war. Jaundice is of common occurrence amongst troops on campaign. In the Soutlh African war a considerable numuber of cases were reported. In the present war jaundice has occurred amongst our troops in almost all parts of the sphere of operations. The cases of jaundice of the epidemic type have fortunately been of a mlild nature generally, and very few deatlhs have been reported. A considerable amount of incapacity for duty lhas, however, resulted, so tlhat epidemic jaundice is a diseaseot importance from the military point of view. The epidemic jaundice of carnpaigns is of great pathological interest, since it tlhrows considerable light on the patlhology of jaundice generally. It will be convenient to consider, first, the symptoms of tlle common type of epidemic jaundice as seen in the Mediterranean area during the later half of the past year. Otlher varieties of jaundice wlhiclh were also observed will tlhen be considered, and the relation between them will be discussed.
Detection of Specific Antibodies in Saliva during Dengue Infection

ABSTRACT Saliva was collected prospectively from patients presenting with suspected dengue infection 4 to 8 days after the onset of symptoms and assayed by a commercial dengue immunoglobulin M (IgM) and IgG capture enzyme-linked immunosorbent assay (ELISA) (PanBio Dengue Duo ELISA). Laboratory diagnosis was based on virus isolation and on hemagglutination inhibition (HAI) assay and an in-house IgM and IgG capture ELISA. With a positive result defined as either salivary IgM or IgG levels above the cutoff value, an overall sensitivity of 92% was obtained for both primary- and secondary-dengue patients (22 of 24), while no patients with non-flavivirus infections (n = 11) and no healthy laboratory donors (n = 17) showed elevation of salivary antidengue antibody (100% specificity). Salivary IgG levels correlated well with serum HAI titer (r = 0.78), and salivary IgG levels could be used to distinguish between primary- and secondary-dengue virus infections.
Reduced VHO latency using EVM measurement and ad hoc cooperation for heterogeneous ubiquitous networks

Future heterogeneous network HetNet will allow mobile ad hoc network MANET to interoperate with WiMAX/LTE/WCDMA/CRN, etc. and will prefer OFDM modulation scheme for better spectrum efficiency. The RF parts of these standards have to face major challenges viz. channel estimation under very strict low power transmission viz. MANET. To exploit the ubiquitous diversity of HetNet, mobile node MN of MANET will prefer to perform vertical handover VHO across the HetNet for better guaranteed QoS and optimal resource utilisation. Considering these design challenges, paper proposes an optimal VHO model to associate a neighbouring ad hoc node CoN to cooperate and perform some parts of the VHO procedure requiring large latencies, such as authentication L1/L2 and IP registration procedures L3 which are based on measurement of error vector magnitude EVM. Performance of proposed VHO architecture is compared with conventional VHO schemes in terms of VHO latency, average service disruption time and reject rate. Proposed algorithm significantly reduces overall VHO latency.
Second‐order spatial analysis of epidermal nerve fibers

Breakthroughs in imaging of skin tissue reveal new details on the distribution of nerve fibers in the epidermis. Preliminary neurologic studies indicate qualitative differences in the spatial patterns of nerve fibers based on pathophysiologic conditions in the subjects. Of particular interest is the evolution of spatial patterns observed in the progression of diabetic neuropathy. It appears that the spatial distribution of nerve fibers becomes more ‘clustered’ as neuropathy advances, suggesting the possibility of diagnostic prediction based on patterns observed in skin biopsies. We consider two approaches to establish statistical inference relating to this observation. First, we view the set of locations where the nerves enter the epidermis from the dermis as a realization of a spatial point process. Secondly, we treat the set of fibers as a realization of a planar fiber process. In both cases, we use estimated second‐order properties of the observed data patterns to describe the degree and scale of clustering observed in the microscope images of blister biopsies. We illustrate the methods using confocal microscopy blister images taken from the thigh of one normal (disease‐free) individual and two images each taken from the thighs of subjects with mild, moderate, and severe diabetes and report measurable differences in the spatial patterns of nerve entry points/fibers associated with disease status. Copyright © 2011 John Wiley & Sons, Ltd.
Integrated Multimedia and Sensor Data Management in Heterogeneous Home Networks: a Concept Proposal

Home Area Networks designed for the delivery of both multimedia contents (e.g. TV programs, movies, music) and home automation services (e.g. household appliances commands, lighting and surveillance controls) are becoming widespread, especially thanks to the latest developments in wireless sensor and communication devices. This kind of networks, however, represents a new challenge for the networking field, particularly with respect to the integration of many different home and building automation solutions, that are not originally conceived to coexist and exchange data. Consequently, it is necessary to introduce an operational infrastructure able to interconnect different devices on the same communication link, or over different links, by means of a single user interface and a unified intelligence, thus making possible a complete and efficient management of the system. This paper outlines the main components in the design of an integrated home network architecture based on both commercial and customized devices developed ad-hoc, and provides preliminary results about the performance obtainable in the delivery of different data flows. The convergence of many differentiated services over IP-based architectures dramatically increases the amount of IP traffic to be delivered to the clients, so that Quality of Service management issues arise, and are to be taken into account.