Miracle-dz/UniFAR-FTUs huggingface dataset:
Alternative Measures for IBS Management

About 30% to 40% of adults claim to have frequent indigestion, and over 50 million visits are made annually to ambulatory care facilities for symptoms related to the digestive system. Irritable bowel syndrome (IBS) is present in patients with symptoms of chronic abdominal pain and altered bowel habits but no identifiable organic etiology. IBS has a prevalence of 1% to 20% worldwide, although up to 75% affected individuals never seek care. Diagnosing IBS can be challenging due to the nonspecific nature of symptoms, overlapping upper and lower abdominal symptoms, and the frequent presence of somatic and psychological comorbidities. Up to 80% of IBS patients identify food as a possible trigger for their symptoms, so they increasingly ask for dietary and behavioral counseling. Moderate-severe IBS is estimated to account for around 60% of all IBS cases and has been shown to impose a considerable burden on patients. It is estimated that IBS-C accounts for around 30% of IBS cases. The economic burden of IBS in the US is estimated at $28 billion annually, a portion of these costs may be related to unnecessary and high-frequency tests, although few studies have assessed the factors underlying frequent tests and procedures among patients with IBS. 32% of IBS-C patients suffer depression as their condition almost every day in the previous month. Sexual dysfunction is positively associated with perceived GI symptom severity and HRQoL.
Detection of Malfunctional Smart Electricity Meters Based on Deep Learning of Electricity Usage Data

Detecting malfunctional smart meters based on electricity usage and targeting them for replacement can save significant resources. For this purpose, we developed a novel deep-learning method for malfunctional smart meter detection based on long short-term memory (LSTM) and a modified convolutional neural network (CNN). Our method uses LSTM to predict the reading of a master meter based on data collected from submeters. If the predicted value is significantly different from master meter reading data over a period of time, the diagnosis part will be activated, classifying every submeter to identify the malfunctional submeter based on CNN. We propose a time series-recurrence plot (TS-RP) CNN, by combining the sequential raw data of electricity and its recurrence plots in the phase space as dual input branches of CNN. By combining this time sequential (TS) raw data with the recurrence plots (RP), we found that the classification performance was much better than when using the sequential raw data only. We compared our method with several classical methods, including the elastic net and gradient boosting regression methods, which show that our method performs better. To the best of our knowledge, our TS†Equal Contribution. *Corresponding authors: Dong Xu (Tel.: +1-573-882-2299; e-mail: xudong@missouri.edu) and Qing He (Tel.: +86-10-64524501; e-mail: heqing@nim.ac.cn).
Spinal cord plasticity in peripheral inflammatory pain

Inflammatory pain is a debilitating condition that can occur following tissue injury or inflammation and results in touch evoked pain (allodynia), exaggerated pain (hyperalgesia) and spontaneous pain, yet the neural plasticity underlying these symptoms is not fully understood. However, it is known that lamina I neurokinin 1 receptor expressing (NK1R+) spinal cord output neurons are crucial for the manifestation of inflammatory pain. There is also evidence that the afferent input to and the postsynaptic response of these neurons may be altered in inflammatory pain, which could be relevant for inflammatory pain hypersensitivity. Therefore, the aim of this thesis was to study inflammatory pain spinal plasticity mechanisms by investigating the synaptic input to lamina I NK1R+ neurons. In ex vivo spinal cord and dorsal root preparations from the rat, electrophysiological techniques were used to assess inflammation-induced changes in and pharmacological manipulation of the primary afferent drive to lamina I NK1R+ neurons. The excitatory input to lamina I NK1R+ neurons was examined and it was found that inflammation did not alter the relative distribution of the type of primary afferent input received and did not potentiate monosynaptic Aδor monosynaptic C-fibre input, the predominant input to these neurons. Spontaneous excitatory input was significantly elevated in the subset of neurons that received monosynaptic Aδ-fibre input only, regardless of inflammation. It has recently been shown that the chemerin receptor 23 (ChemR23) represents a novel inflammatory pain target, whereby ChemR23 agonists can decrease inflammatory pain hypersensitivity, by a mechanism that involves the attenuation of potentiated spinal cord responses. This study has found that the ChemR23 agonist, chemerin, attenuated capsaicin potentiation of excitatory input to lamina I NK1R+ neurons and significantly reduced monosynaptic C-fibre input to a subset of these neurons in inflammatory pain. However, chemerin was without effect in non-potentiated conditions. In exploring potential inflammatory pain spinal plasticity mechanisms, I have investigated a phenomenon called activity-dependent slowing (ADS), whereby repetitive stimulation of C-fibres at frequencies of 1Hz or above results in a progressive slowing of action potential conduction velocity, which manifests as a progressive increase in response latency. This is proposed to limit nociceptive input to the spinal cord, thus regulating plasticity. Results demonstrate that inflammation
Blood flow of the anterior and posterior cruciate ligament in a canine model

The vascular supply of the anterior and posterior cruciate ligaments was investigated in 21 adult dogs. The investigations were camed out under general anesthesia, and respirators were used. Measurements of the blood supply were performed by means of a microsphere technique. The ligaments were divided equally into a proximal part, a middle part and a distal part. Values recorded regarding the 3 parts of the anterior ligament were 3.0, 2.2 and 3.5 ml per 100 g of tissue per min respectively. As to the posterior ligament the respective values were 2.8, 2.8, and 3.2 ml per 100 g of tissue per min. No significant difference between the two ligaments or their various parts could be detected.
Industrial Organization and Customer Relationship Management : The Impact on Customer Service Orientation in BtoB Markets

Despite the widespread adoption of customer relationship management (CRM) systems by firms operating in business-to-business markets, there is continued management skepticism concerning the effectiveness of these systems and their association with the firm’s overall “customer information orientation. ” The research focuses on these topics by looking at the relationship of customer relationship management with overall firm performance in B-to-B settings across a range of traditional business performance measures. The researchers use an advanced statistical approach to determine the key variables for activating the model constructs The findings of the research provide support for the result that a firm’s customer orientation is indeed associated with relationships management system implementation in a firm.
Adaptive Groundwater Governance and the Challenges of Policy Implementation in Idaho’s Eastern Snake Plain Aquifer Region

Globally, groundwater overdraft poses significant challenges to agricultural production. As a result, it is likely that new water management policies and governance arrangements will be needed to stop groundwater depletion and maintain agricultural viability. Drawing on interviews with state and non-state water managers and other water actors, this paper provides a study of a recent resource management agreement between surface water and groundwater irrigators in the Eastern Snake Plain Aquifer region of Idaho. Using adaptive governance as our descriptive framework, we examine how groundwater governance arrangements emerge and are applied to mitigate the impacts of groundwater overdraft. Our findings suggest that adaptive governance, while not a stated goal of the agreement, may enable flexible and sustainable social and ecological outcomes. Our findings also indicate that this new governance arrangement creates a vacuum in enforcement authority that may prove challenging as the management agreement is implemented. These findings extend our understanding of the conditions necessary for effective adaptive governance of groundwater resources, and highlight the challenge of creating capacity for local resource managers as governance shifts from more bureaucratic to adaptive and decentralised arrangements.
Effectiveness of omalizumab in improving quality of life in patients with 'steroid-resistant' asthma and severe allergic rhinitis

Asthma is a heterogeneous disease, not only in its clinical expression and course but also in its response to treatment with deleterious effects on Quality of life (QoL). Anti- IgE can spare these patients with unnecessary exacerbations and have a better QoL. The objective of this study was to evaluate the effectiveness of omalizumab treatment in improving QoL in patients with severe allergic rhinitis and asthma. Methods: 41 patients aged > 18 years with steroid-resistant asthma were enrolled in this open label study. Patients were examined at baseline and were treated with omalizumab administered subcutaneously every 2 or 4 weeks (at least 0.016 mg/kg/IgE IU/ml), in addition to existing treatment. At both visits, investigators assessed QoL on a 4 point scale in the following domains: nasal, ocular and asthmatic symptoms. Scores were calculated for individual symptoms, total scores for each domain. Patients were also assessed on impairment of sleep and daily activities. Results: Omalizumab significantly reduced scores from baseline in both nasal and ocular symptoms. Reductions were also seen in the asthmatic symptom scores: significance was noted in wheezing (P=0.0002) and breathless scores (P=0.0002). At baseline, 62 % of patients had some degree of daily activity impairment, whereas at the final visit only 31% had daily activity impairment. Similarly, while 55% of patients had some sleep impairment at baseline, this was reduced to 28% at the final visit. Conclusions: This open label study demonstrated that omalizumab was an effective treatment for the symptoms and sleep/daily life impairments associated with severe allergic rhinitis and asthma.
Comparative Evaluation of Antibiotic Residues in Raw Milk Samples by ECLIPS 50 and TWINE SENSOR kits in Sepidan and Beyza , Iran

Background: This research was conducted to evaluate antibiotic residues in raw milk samples in Sepidan, using ECLIPS 50 kit and TWINE SENSOR kit. Methods: In this cross-sectional study, one hundred raw cow milk samples were randomly collected from different farms and milk factories in Sepidan and Beyza townships from winter 2017 to spring 2018. The ECLIPS 50 and TWINE SENSOR kits were used to monitor antibiotic residues in milk samples. The data were analyzed employing Chi-square test, using SPSS software version 20. The significance level was considered P<0.05. Results: In total, 100 raw milk samples were collected, of which 60 (60%) were from Beyza and 40 (40%) from Sepidan. A total of 95 samples (95%) were antibiotic-free and 5 (5%) contained antibiotic residual. 5 samples (5%) of ECLIPS 50 kit, 5 samples (5%) of TWINE SENSOR kit were shown to be positive, using both kits. Conclusion: There was no difference between ECLIPS 50 kit and TWINE SENSOR kits in detecting antibiotics residue in raw milk samples. The positive samples in the two sets of kits were identical. Furthermore, there was no significant difference between the two types of kits regarding the season and region. Please cite this article as: Mollaei AR, Hamidian Shirazi M, Hamidian Shirazi AR. Comparative Evaluation of Antibiotic Residues in Raw Milk Samples by ECLIPS 50 and TWINE SENSOR kits in Sepidan and Beyza, Iran. J Health Sci Surveillance Sys. 2018;6(2):105-109.
Developing the RELevator for Exploration of 3 Dimensional Spatial Representations of Rodent Hippocampal Place Cells

ー​We propose an experimental paradigm utilizing a novel semi-autonomous control system, the RELevator, to determine hippocampal spatial representations of 3 dimensions. Specifically, we want to determine the role of hippocampal place cells in 3 dimensional representations, a difficult feat due to the brain’s tendency to encode only necessary information to complete a task. We show how the RELevator provides a 3 dimensional task that cannot be completed with 2 dimensional encoding, differing from the majority of past studies and may present results countering those pre-existing. We also show how the proposed RELevator will account for inherent biases, producing spatial representation that rodents would innately form only when presented with a similarly dimensionally complex task in their natural environment, such as burrowing.
Long noncoding RNA NEAT 1 ( nuclear paraspeckle assembly transcript 1 ) is critical for phenotypic switching of vascular smooth muscle cells

Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912; Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, China; Department of Cardiology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, China; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202; Department of Pharmacology, Tianjin Medical University, 300052 Tianjin, China; Department of Surgery, Medical College of Georgia, Augusta University, Augusta, GA 30912; Institute for Genetic Medicine, Hokkaido University, 060-0815 Sapporo, Japan; and RNA Biology Laboratory, Faculty of Pharmaceutical Sciences, Hokkaido University, 060-0815 Sapporo, Japan
Domeyko — an early investigator of Andean geology

In 2002, the name of Ignacy Domeyko was listed in UNESCO's list of famous persons. The bicentenary of this famous nineteenth-century scholar and teacher, geologist, mineralogist, and ethnographer was widely celebrated in Chile, Lithuania, Belarus, Poland, France (Grigelis, ed., 2002). Ten years after his arrival in Chile, Domeyko published an article entitled Mémoire sur la constitution géologique de Chili (Annales des Mines, Series 4, Volume 9, 1846), in which he suggested an ongoing tectonic factor forming the Andean Cordilleras:
Handbook of occupational health psychology

Prevention at Work - Public Health in Occupational Settings A History of Occupational Health Psychology Controlling Occupational Safety and Health Hazards Toward an Integrated Framework for Comprehensive Organizational Wellness - Concepts, Practices, and Research in Workplace Health Promotion Health Psychology and Work Stress - A More Positive Approach Safety Climate - Conceptual and Measurement Issues Work-Family Balance Shiftwork and Working Hours Occupational Stress - Job Pressures and Lack of Support To Be Able to Exert Control Over One's Own Situation - A Necessary Condition for Coping with Stresses Technology and Workplace Health Job-Related Burnout - A Review The Workplace and Cardiovascular Disease Employee Assistance Programs Worksite Health Interventions - Targets for Change and Strategies for Attaining Them Job Stress Interventions and Organization of Work Stress Management at Work An Epidemiological Perspective on Research Design, Measurement, and Surveillance Strategies Program Evaluation - The Bottom Line in Organizational Health Economic Evaluations of Workplace Health Interventions - Theory and Literature Review.
The Influence of Customer Relationship Marketing on Corporate Social Responsibility , Bank Image , Service Quality , and Its Impact on Employees of SME Employees Saving BNI Syariah Regional Operation of

This research is about Influence of Customer Relationship Marketing to Corporate Social Responsibility, Bank Image, Service Quality, and Its Impact On Saving Customer Decision at BNI Syariah Bank in Kediri.The study population was 161,821 savings customers, BNI Syariah Bank in Kediri. Number of smpel for 240 respondents, who came from 10 times 24 indicators of variables in the study.Test model with Generalized Least Square Estimation (GLS), structural equation model (SEM) analysis, proportional random sampling method and Amos 22 software aid, in 240 respondents. The test results show the model (fit) seen from the value of GFI, AGFI, TLI, CFI, RMSEA and CMIN / DF, each of 0.927, 0.912, 0.951, 0.957, 0.062 and 1.463 are all within the expected range of values so that the model can be accepted. The results showed that: 1). Customer relationship marketing affects corporate social responsibility Bank BNI Syariah. 2). Customer relationship marketing affects the image of Bank BNI Syariah. 3). Customer relationship marketing affects the quality of Bank BNI Syariah service. 4). Corporate social responsibility affects the quality of Bank BNI Syariah services. 5). Corporate social responsibility has no significant effect on the image of Bank BNI Syariah. 6). Quality of service affects the image of Bank BNI Syariah. 7). Quality of service affects the decisions of customers of Bank BNI Syariah. 8). The image of the bank affects the decisions of customers of Bank BNI Syariahin Kediri.
Evaluation of Normalized Systems Theory applied on Evolutionary IS Implementation

Nowadays, to follow continuously changing markets, organizations need to make changes and increase complexity of their Information Systems (IS). These systems, nevertheless, have plenty of dependencies that make changes harder. This dissertation goal is to evaluate if the Normalized Systems theory (NST) allows organizations to deliver fast and e ective changes, as well as increase the complexity of the Information Systems (e.g. increase number of functionalities, requirements and interfaces) making them agile and evolutionary. The proposed methodology consists in applying NST in the development of an E-Voting System (EVS). Afterwards, by using another system (similar to the one developed) it was possible to prove the usefulness of the theory in the development of evolutionary information systems, through the analysis of some quantitative software evaluation metrics (applied to both).
Prevalence of Theileria annulata in dairy cattle in Mashhad area, Iran

A total of 160 dairy cattle from 78 farms were clinically examined and investigated for the presence of Theileria spp. , Anaplasma spp. in blood smears in Mashhad area, in Iran from 2002 to 2003. The prevalence of Theileria annulata and Anaplasma marginale infection was 32 (20%) and 15 (9.38%), respectively. Mixed infections occurred in 9 (5.62%) dairy cattle. The parasitaemia of Theileria annulata infection was higher than Anaplasma marginale infection and clinical signs were observed in 23 (14.37%) dairy cattle that were infected with Theileria annulata. In the present study, the highest prevalence of Theileria annulata infection in dairy cattle was observed in less than 1 year old animals (40%) and seasonally in summer (45%). In addition, the prevalence of Anaplasma marginale infection in relation to age and season was not statistically significant.
Aalborg Universitet Culture-Related Topic Selection in Small Talk Conversations across Germany and Japan

Small talk can be used in order to build a positive relationship towards a virtual character. However the choice of topics in a conversation can be dependent on social background. In this paper, we explore culture-related differences in small talk for the German and Japanese cultures. Based on findings from the literature and verified by a corpus analysis, we integrated prototypical German and Japanese small talk conversations into a multiagent system. In evaluation studies conducted in the two target cultures, we investigated whether participants prefer agent dialogs that were designed to reflect their own cultural background.
ENERGY CONDITIONS AND THEIR COSMOLOGICAL IMPLICATIONS MATT VISSER and CARLOS BARCELÓ

The energy conditions of general relativity permit one to deduce very powerful and general theorems about the behaviour of strong gravitational fields and cosmological geometries. However, the energy conditions these theorems are based on are beginning to look a lot less secure than they once seemed: (1) there are subtle quantum effects that violate all of the energy conditions, and more tellingly (2), there are also relatively benign looking classical systems that violate all the energy conditions. This opens up a Pandora’s box of rather disquieting possibilities — everything from negative asymptotic mass, to traversable wormholes, to warp drives, up to and including time machines.
Dementia Care Mapping and Patient-Centred Care in Australian residential homes: An economic evaluation of the CARE Study, CHERE Working Paper 2008/4

Background: As the population ages, the incidence of dementia and its burden on society will increase. The economic costs of dementia are high, particularly for persons in the mid and late stages of the disease, when formal care arrangements such as nursing home placement are required. The need for care is often precipitated by the development of behavioural and psychological symptoms of dementia (BPSD) which also severely affect the quality of life of affected persons and their carers The Caring for Aged-Care REsident Study (CARES), the first randomised controlled trial to evaluate Dementia Care Mapping (DCM) and Person Centred Care (PCC), demonstrated that either of the two interventions improved outcomes compared to Usual Care (UC) on the primary outcome measure, the Cohen-Mansfield Agitation Inventory (CMAI). This study reports the results of an economic evaluation which was undertaken in conjunction with the trial. This information will provide additional information to assist policy makers in making choices between competing options. Methods: Fifteen nursing homes were randomised to one of three conditions: DCM, PCC or Usual Care (UC). The sample consisted of 360 residents with dementia. Data were collected at baseline, three months, and eight months by assessors blind to group assignment. In addition to the CMAI, data were collected about the use and costs of health care resources and pharmacological interventions. Total costs associated with each of the interventions were estimated, which were contrasted with the outcomes using standard health economics methodology. Results: Over one year, the cost per residential setting of implementing DCM and PCC relative to UC was $10,034 and $2,250 respectively. The additional cost per resident-level unit improvement in CMAI post-intervention (at follow-up) relative to UC was $48.95 ($46.89) for DCM and $8.01 ($6.43) for PCC. Compared to DCM, PCC produced a greater reduction in anxiety and agitation at a lower cost. Therefore, DCM was dominated by PCC and removed from the economic evaluation. Sensitivity analysis suggests this result is robust to changing model parameters. Conclusions: PCC provides a greater decrease in agitation and related behavioural and psychological symptoms of dementia, compared with DCM, at a lower cost and is the preferred option for cost-effectiveness. While there is no existing standard for a reasonable cost for a point improvement in CMAI, the cost per unit under PCC seems acceptable.