Miracle-dz/UniFAR-FTUs huggingface dataset:
Delayed retrieval of a hollow foreign body from the trachea of an 850-g newborn.

American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. J Am Coll Cardiol 2007;50:e159–e241 2. Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Villar JC, Xavier D, Chrolavicius S, Greenspan L, Pogue J, Pais P, Liu L, Xu S, Malaga G, Avezum A, Chan M, Montori VM, Jacka M, Choi P. Effects of extendedrelease metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 2008;371:1839–47 3. Gianni M, Dentali F, Grandi AM, Sumner G, Hiralal R, Lonn E. Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur Heart J 2006;27:1523–9 4. Reich DL, Hossain S, Krol M, Baez B, Patel P, Bernstein A, Bodian CA. Predictors of hypotension after induction of general anesthesia. Anesth Analg 2005;101:622–8 5. Beattie WS, Wijeysundera DN, Karkouti K, McCluskey S, Tait G. Does tight heart rate control improve beta-blocker efficacy? An updated analysis of the noncardiac surgical randomized trials. Anesth Analg 2008;106:1039–48 6. Sebel PS, Bovil JG. Cardiovascular effects of sufentanil anesthesia. Anesth Analg 1982;61:115–9 7. Spiess BD, Sathoff RH, el-Ganzouri AR, Ivankovich AD. High-dose sufentanil: four cases of sudden hypotension on induction. Anesth Analg 1986;65:703–5 8. Starr NJ, Sethna DH, Estafanous FG. Bradycardia and asystole following the rapid administration of sufentanil with vecuronium. Anesthesiology 1986;64:521–3
Improvements on a MMI-based method for automatic texture mapping of 3D dense models

Maximization of Mutual Information routines proved to be suitable for registration of multimodal images. Here a method is proposed to select, in a set of candidates, the image which has a closer resemblance with a given external one. Such algorithm is intended to serve within a wider scope procedure for the automatic texturing of 3D models, where the initial 2D-3D registration problem is shifted to a 2D-2D registration challenge. In order to improve its performance a number of variations in the way the Mutual Information is computed are introduced and a method to judge its reliability is proposed.
Role of Oxygen Vacancies in Short- and Long-Term Instability of Negative Bias-Temperature Stressed SiC MOSFETs

We use hybrid-functional density functional theory to study the role of oxygen vacancies in negative bias-and-temperature stress-induced threshold voltage instability in 4H-silicon carbide power MOSFETs. According to our model, certain originally electrically “inactive” oxygen vacancies are structurally transformed into electrically “active” defects in the presence of strong negative bias and temperature. These newly generated defect configurations function as short-lived or long-lived switching oxide hole traps. The transients of their generation process are shown to correlate well with the measured “short-term” threshold voltage instability. Additionally, we show that the long-lived defects continue to degrade the room-temperature reliability of these devices even after stress removal.
The Semiring Framework for Database Provenance

Imagine a computational process that uses a complex input consisting of multiple "items" (e.g.,files, tables, tuples, parameters, configuration rules) The provenance analysis of such a process allows us to understand how the different input items affect the output of the computation. It can be used, for example, to derive confidence in the output (given confidences in the input items), to derive the minimum access clearance for the output (given input items with different classifications), to minimize the cost of obtaining the output (given a complex input item pricing scheme). It also applies to probabilistic reasoning about an output (given input item distributions), as well as to output maintenance, and to debugging. Provenance analysis for queries, views, database ETL tools, and schema mappings is strongly influenced by their declarative nature, providing mathematically nice descriptions of the output-inputs correlation. In a series of papers starting with PODS 2007 we have developed an algebraic framework for describing such provenance based on commutative semirings and semimodules over such semirings. So far, the framework has exploited usefully the observation that, for database provenance, data use has two flavors: joint and alternative. Here, we have selected several insights that we consider essential for the appreciation of this framework's nature and effectiveness and we also give some idea of its applicability.
On the Design of Single-Layer Circuit Analog Absorber Using Double-Square-Loop Array

A detailed study of a single-layer circuit analog absorber using double-square-loop array reveals that three resonances can be obtained within its operating frequency band. An equivalent circuit model is proposed to explain how these three resonances can be produced and its absorption bandwidth can be widened. Simple guidelines for the design of this double-square-loop absorber are then formulated. It is shown through measurements that the fractional bandwidth of 126.8% is realized for at least 10 dB reflectivity reduction under the normal incidence. Furthermore, the total thickness of the proposed design is only 0. 088λL at the lowest operating frequency. A good agreement between simulated and measured results demonstrates the validity of our design.
Relapse Situations According to Marlatt’s Taxonomy in Smokers

Abstract Relapse is common during the process of giving up smoking. The aim of the present study is to explore the relapse situations, according to Marlatt’s relapse taxonomy, in a sample of 428 smokers (43.9% men and 56.1% women) who participated in a cognitive-behavior psychological treatment for quitting smoking. At the end of the treatment, 221 participants were abstinent, of whom 119 (41.2% men and 58.8% women) relapsed in the course of the 12-month follow-up, the majority in the first 3 months (69.74%). Most of the relapses were attributed to intrapersonal and environmental determinants (61.33%), the most common of which were “coping with negative emotional states” (38.65%), followed by “giving in to temptations or urges” (9.24%) and “testing personal control” (8.40%). Interpersonal determinants occurred in 38.66% of relapses, this percentage being made up mostly of “social pressure”, which was the relapse situation in 34.46% of all relapses. These results, similar to those of Marlatt’s original studies and others, contribute to improving our knowledge of the relapse situations process, with a view to interventions that may help to avoid it.
Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver.

SIGNIFICANCE Hepatic ischemia-reperfusion (IR) injury results from the temporary deprivation of hepatic blood supply and is a common side effect of major liver surgery (i.e., transplantation or resection). IR injury, which in most severe cases culminates in acute liver failure, is particularly pronounced in livers that are affected by non-alcoholic fatty liver disease (NAFLD). In NAFLD, fat-laden hepatocytes are damaged by chronic oxidative/nitrosative stress (ONS), a state that is acutely exacerbated during IR, leading to extensive parenchymal damage. RECENT ADVANCES NAFLD triggers ONS via increased (extra)mitochondrial fatty acid oxidation and activation of the unfolded protein response. ONS is associated with widespread protein and lipid (per)oxidation, which reduces the hepatic antioxidative capacity and shifts the intracellular redox status toward an oxidized state. Moreover, activation of the transcription factor peroxisome proliferator-activated receptor α induces expression of mitochondrial uncoupling protein 2, resulting in depletion of cellular energy (ATP) reserves. The reduction in intracellular antioxidants and ATP in fatty livers consequently gives rise to severe ONS and necrotic cell death during IR. CRITICAL ISSUES Despite the fact that ONS mediates both NAFLD and IR injury, the interplay between the two conditions has never been described in detail. An integrative overview of the pathophysiology of NAFLD that renders steatotic hepatocytes more vulnerable to IR injury is therefore presented in the context of ONS. FUTURE DIRECTIONS Effective methods should be devised to alleviate ONS and the consequences thereof in NAFLD before surgery in order to improve resilience of fatty livers to IR injury.
AINTEGUMENTA Promotes Petal Identity and Acts as a Negative Regulator of AGAMOUS

The Arabidopsis AINTEGUMENTA (ANT) gene has been shown previously to be involved in ovule development and in the initiation and growth of floral organs. Here, we show that ANT acts in additional processes during flower development, including repression of AGAMOUS (AG) in second whorl cells, promotion of petal epidermal cell identity, and gynoecium development. Analyses of ap2-1 ant-6 double mutants reveal that ANT acts redundantly with AP2 to repress AG in second whorl cells. The abaxial surface of ant petals contains features such as stomata and elongated, interdigitated cells that are not present on wild-type petals. The loss of petal identity in these second whorl cells does not result from ectopic AG expression, suggesting that ANT acts in a pathway promoting petal cell identity that is independent of its role in repression of AG. These data suggest that ANT may function as a class A gene.
415W Single-Mode CW Thulium Fiber Laser in all-fiber format

High power Tm lasers at 2um region is a great source of interest for many application including optical pumping of hybrid (fiber-solid state) lasers, bio-medical, remote sensing and plastic welding. Cladding-pumped single-mode Tm-doped fiber lasers demonstrate significant advantages over solid state Tm lasers. Over last several years multiple groups [1,2] using different techniques demonstrated power scaling of fiber bas ed Tm laser to above 100W level. In this paper, we report a development of a single mode all-fiber format Tm fiber laser with M -value of < =1.1, emission linewidth of <1 nm at 1940nm and output power exceeding 400W CW. This is a highest CW output power for a single-mode Tm fiber laser reported up to date.
Planar lens antenna based on low-pass frequency selective surfaces

A planar lens antenna based on low-pass frequency selective surfaces is presented in this paper. The presented lens operates at 1.7–2.2GHz and shows a low-profile structure with an overall thickness of 0.2 operating wavelength. A dipole antenna array is used as the feed. The simulation results show that the antenna presents high aperture efficiency and the gain reaches 17.69dBi. The scanning beam within a range of ±30° is achieved.
Role of Heat Shock Protein 27 in Cardiovascular Disease

Small heat shock proteins are ubiquitous ATP-independent chaperones whose expression is induced by a wide variety of physiological and environmental stress. Heat shock protein 27 (Hsp27 or HspB1) is one of the best characterized members of the sHsp family. In addition to its chaperone function, several positive biological effects exerted by this protein have gained attention, such as anti-oxidant, anti-inflammatory and anti-apoptotic. This review article provides a comprehensive overview of structure, expression and functional aspects of Hsp27 in relation to cardiovascular disease (CVD). Moreover, this review also presents overwhelming evidence in support of the role of Hsp27 in the pathophysiology of cardiovascular disease (CVD), as well as its therapeutic and clinical implications.
Maximum Power Point Tracking Based on Estimated Power for PV Energy Conversion System

Abstract—In this paper, a method for maximum power point tracking of a photovoltaic energy conversion system is presented. This method is based on using the difference between the power from the solar panel and an estimated power value to control the DC-DC converter of the photovoltaic system. The difference is continuously compared with a preset error permitted value. If the power difference is more than the error, the estimated power is multiplied by a factor and the operation is repeated until the difference is less or equal to the threshold error. The difference in power will be used to trigger a DC-DC boost converter in order to raise the voltage to where the maximum power point is achieved. The proposed method was experimentally verified through a PV energy conversion system driven by the OPAL-RT real time controller. The method was tested on varying radiation conditions and load requirements, and the Photovoltaic Panel was operated at its maximum power in different conditions of irradiation.
An Equilibrium Model of Tax Abatement

The model of tax abatements includes taxing district and firm characteristics to explain a locality’s abatement generosity. The community-level characteristics are for the school district in the enterprise zone that grants the tax abatement. Firm characteristics include the size, credit rating, number of newly created and/or retained jobs, and the quality of the jobs. Generosity of abatements is measured by the percentage of taxes abated. Firms that had credit ratings showing them to be more suitable risks fared better in negotiations; those that brought newly created jobs garnered more generous abatements; and those that promised retained jobs in the negotiation fared less well.
Insulin priming effect on estradiol-induced breast cancer metabolism and growth

Diabetes is a risk factor for breast cancer development and is associated with poor prognosis for breast cancer patients. However, the molecular and biochemical mechanisms underlying the association between diabetes and breast cancer have not been fully elucidated. Here, we investigated estradiol response in MCF-7 breast cancer cells with or without chronic exposure to insulin. We found that insulin priming is necessary and specific for estradiol-induced cancer cell growth, and induces anaplerotic shunting of glucose into macromolecule biosynthesis in the estradiol treated cells. Treatment with ERK or Akt specific inhibitors, U0126 or LY294002, respectively, suppressed estradiol-induced growth. Interestingly, molecular analysis revealed that estradiol treatment markedly increases expression of cyclin A and B, and decreases p21 and p27 in the insulin-primed cells. In addition, estradiol treatment activated metabolic genes in pentose phosphate (PPP) and serine biosynthesis pathways in the insulin-primed cells while insulin priming decreased metabolic gene expression associated with glucose catabolism in the breast cancer cells. Finally, we found that anti-diabetic drug metformin and AMPK ligand AICAR, but not thiazolidinediones (TZDs), specifically suppress the estradiol-induced cellular growth in the insulin-primed cells. These findings suggest that estrogen receptor (ER) activation under chronic hyperinsulinemic condition increases breast cancer growth through the modulation of cell cycle and apoptotic factors and nutrient metabolism, and further provide a mechanistic evidence for the clinical benefit of metformin use for ER-positive breast cancer patients with diabetes.
On the shoulders of giants

Carson stimulated a foundational change in the United States, and perhaps in the world. Her most infl uential work, Silent Spring (1962), was a powerful and insightful analysis of human infl uence on the environment. The work was considered depressing for many – not because of the tenor or the language used, but because of its clarity and stark view of habitat destruction. Publication of Silent Spring coincided with the rapid post-war growth in the United States, a time of exorbitant use of resources and disregard of the environment at a staggering rate. Carson predicted the trajectory this behavior would have on ecosystems. She particularly pointed out that, contrary to what society believed, the world was not an endless resource; rather, ignorance of downstream, ecosystems-level consequences to human actions would only accelerate the decline of our habitats.
EMBRYONIC FLOWER1 Participates in Polycomb Group–Mediated AG Gene Silencing in Arabidopsis[W]

Polycomb group (PcG)–mediated gene silencing is a common developmental strategy used to maintain stably inherited repression of target genes and involves different protein complexes known as Polycomb-repressive complexes (PRCs). In animals, the two best-characterized PcG complexes are PRC1 and PRC2. In this report, we demonstrate that the plant-specific protein EMBRYONIC FLOWER1 (EMF1) functions in maintaining the repression of the flower homeotic gene AGAMOUS (AG) during vegetative development in Arabidopsis thaliana by acting in concert with the EMF2 complex, a putative equivalent of Drosophila melanogaster PRC2. We show that AG regulatory sequences are required for its ectopic expression in both emf1 and emf2 mutants and that EMF2 is required for trimethylation of histone 3 lysine 27 on the AG chromatin. We found that EMF1 interacts directly with AG and that this interaction depends on the presence of EMF2. Together with the finding of EMF1 interference with transcription in vitro, these results suggest that EMF1 enables transcriptional repression of AG after the action of the putative EMF2 complex. Our data indicate that EMF1 plays a PRC1-like role in the PcG-mediated floral repression mechanism.
Cytomegalovirus glycoprotein B genotypes and central nervous system disease in AIDS patients

To investigate any association between cytomegalovirus glycoprotein B (CMV gB) subtypes and central nervous system (CNS) disease in AIDS patients, proportions of different gB genotypes detected in AIDS patients with CNS disease were compared with the gB genotypes detected in AIDS patients with no neurological disorder. The patients were matched by CD4+ cell counts. CMV was detected by PCR in cerebrospinal fluid (CSF) samples obtained from AIDS patients with CNS disease and from urine and saliva samples obtained from AIDS patients without CNS disease. CMV strains obtained were digested by restriction enzymes HinffI and RsaI to classify the genotypes. The CMV gB genotype was determined in 26 CSF samples. Of these, 11/26 (42.3%) typed as gB group 1, seven (26.9%) as gB2, four (15.4%) as gB3, and four (15.4%) as gB4. The CMV gB genotype frequency distribution in the 42 AIDS patients without CNS disease showed that 18/42 (42.8%) were classified as gB group 1, 10 (23.8%) as gB2, seven (16.6%) as gB3, and seven (16.6%) as gB4. In the present study, no association was found between CMV gB genotypes and CMV‐related central nervous system disease. J. Med. Virol. 71:404–407, 2003. © 2003 Wiley‐Liss, Inc.
The Role of One‐Carbon Metabolism in Schizophrenia and Depression

Objective: Physicians often check folate and cobalamin levels in patients with schizophrenia and depression. The reasons for this practice are reviewed, as well as implications for treatment. Method: The physiology of the one‐carbon cycle, involving folate, cobalamin, homocysteine, S‐adenosyl‐methionine, and methylene tetrahydrofolate reductase (MTHFR) is first reviewed, and then the particular contributions of folate and B12 are reviewed. PubMed was searched for studies of the association between folate, cobalamin, homocysteine, and MTHFR polymorphisms and schizophrenia and depression. Results: The recent key studies from the large literature addressing these topics are summarized. Treatment implications are discussed. Conclusion: It is important to check folate and B12 levels in certain situations, such as alcoholism, malnutrition, malabsorption, and the concurrent use of some medications. Checking homocysteine and methylmalonic levels might be useful. With respect to treatment, folate and cobalamin deficiencies should be corrected. Cobalamin supplementation is probably not helpful. Folate supplementation is indicated in pregnancy but may exacerbate the effects of cobalamin deficiency. SAMe may prove to be a useful antidepressant. In the future, screening for MTHFR polymorphisms might be useful.
Physical and Functional Interactions between Receptor-like Protein-tyrosine Phosphatase α and p59 fyn *

We have examined the in vivo activity of receptor-like protein-tyrosine phosphatase α (PTPα) toward p59 fyn , a widely expressed Src family kinase. In a coexpression system, PTPα effected a dose-dependent tyrosine dephosphorylation and activation of p59 fyn , where maximal dephosphorylation correlated with a 5-fold increase in kinase activity. PTPα expression resulted in increased accessibility of the p59 fyn SH2 domain, consistent with a PTPα-mediated dephosphorylation of the regulatory C-terminal tyrosine residue of p59 fyn . No p59 fyn dephosphorylation was observed with an enzymatically inactive mutant form of PTPα or with another receptor-like PTP, CD45. Many enzyme-linked receptors are complexed with their substrates, and we examined whether PTPα and p59 fyn underwent association. Reciprocal immunoprecipitations and assays detected p59 fyn and an appropriate kinase activity in PTPα immunoprecipitates and PTPα and PTP activity in p59 fyn immunoprecipitates. No association between CD45 and p59 fyn was detected in similar experiments. The PTPα-mediated activation of p59 fyn is not prerequisite for association since wild-type and inactive mutant PTPα bound equally well to p59 fyn . Endogenous PTPα and p59 fyn were also found in association in mouse brain. Together, these results demonstrate a physical and functional interaction of PTPα and p59 fyn that may be of importance in PTPα-initiated signaling events.
Do older females store more heat than younger females during exercise in the heat?

INTRODUCTION Aging is associated with a reduction in the body's capacity to dissipate heat. To date, few studies have examined age-related changes in thermoregulatory function during short exercise periods in the heat in older females. PURPOSE This study aimed to investigate the effects of age on whole-body heat loss during intermittent exercise in the heat in young and older females. METHODS Direct and indirect calorimetry was used to measure whole-body evaporative heat loss (EHL), change in body heat content, and metabolic heat production. Eleven young (Y) (mean ± SD age = 24 ± 4 yr) and 13 older (O) (51 ± 8 yr) females matched for body surface area (Y, 1.72 ± 0.15; O, 1.75 ± 0.12 m²) and fitness (V(˙)O(2max)) (Y, 36.7 ± 6.8 mL O₂·kg⁻¹·min⁻¹; O, 33.8 ± 8.0 mL O₂·kg⁻¹·min⁻¹) performed four bouts of 15-min cycling (Ex1, Ex2, Ex3, and Ex4) at a constant rate of heat production (300 W) at 35°C and 20% relative humidity. Each exercise bout was separated by 15 min of rest. RESULTS EHL was reduced in O compared with Y during Ex1 (O, 199 ± 6 W; Y, 240 ± 9 W; P = 0.001), Ex2 (O, 238 ± 4 W; Y, 261 ± 9 W, P = 0.023), and Ex3 (O, 249 ± 4 W; Y, 274 ± 11 W; P = 0.040). EHL was not different between groups during Ex4 or during the recovery periods. Older females had a greater change in body heat content compared with young females (O, 270 ± 20 kJ; Y, 166 ± 20 kJ; P = 0.001). CONCLUSION These findings suggest that older females have a lower capacity for whole-body EHL compared with younger females during short intermittent exercise in the heat performed at a fixed rate of metabolic heat production.
Breakthrough Technologies Transcription Activator-Like Effector Nucleases Enable

Department of Biotechnology, School of Life Sciences and Technology, University of Electronic Science and Technology of China, Chendu 610054, People’s Republic of China (Y.Z.); Department of Genetics, Cell Biology, and Development and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455 (Y.Z., X.L., J.A.B., Y.Q., C.G.S., D.F.V.); Cellectis Plant Sciences, St. Paul, Minnesota 55114 (F.Z., D.F.V.); and Department of Plant Pathology and Microbiology, Iowa State University, Ames, Iowa 50011 (A.J.B.)