Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of an ultra-miniaturized IMU-based motion capture system for objective evaluation and assessment of walking skills

The increasing age of the world population is posing new challenges to our society, such as how to keep this aging population healthy and active despite of the age. In recent years, there has been a lot of interest for gait analysis for rehabilitation purposes as well as for performance assessment of this aging population. While current systems work well, they still have several limitations. Cost, need for specialized personnel, need to be used in a research center, and sporadic measurement prevent these systems from being widely used. The authors propose the use of extremely miniaturized, portable measurement systems, which can be worn by the users during their everyday life, and can monitor their gait over a long timespan. This paper presents the preliminary experiments with such a system.
The Future is Female: Bateson, Benjamin and How Women Learn in Ridley Scott's Prometheus

Science fiction, that child of imagination and experience, of science and literature, has served as both warning and roadmap. Sadly, recent American iterations of adventures into the future simply continue battles fought on earth: space cowboys slam down aliens bigger, hairier, smarter, more violent than humans. Even the most intellectual space odyssey, Star Wars, had a ritual duel between father and son at its core. A wearying rehearsal of male angst animates even worlds free of gravity and depleted of oxygen. These allegories illustrate much can happen without anything changing — they supply no roadmap, no warning, but rather reinforce habitual patterns of thought and action. With his creation of Sigourney Weaver’s nearly eponymous Ripley, commander and kitten-handler of the original Alien, Ridley Scott suggested a new model of humanity: a female, fragile, thoroughly human scientist. The latest avatar of his hero is Elizabeth Shaw, who in Scott’s 2012 film Prometheus survives the brutal Darwinian world of eat or be eaten (and digested onscreen) through what can only be called the reinvention of the free will of the imagination. Shaw is a scientist. She lives in a world of facts. For Scott, however, facts are factoids unless warmed by the fire of individual curiosity, and the fact that Shaw chooses to engage with her reality in original ways animates her actions and desires.
The power and efficiency of brood incubation in queenless microcolonies of bumble bees (Bombus terrestris L.)

1. Ground‐nesting colonies of bumble bees incubate their brood at > 30 °C if floral forage provides sufficient energy and the thermogenic power of the colony can counteract cool soil conditions. To explore the basis of incubation, the thermogenic power and sugar consumption of orphaned nests of bumble bee workers (microcolonies) were investigated under laboratory conditions.
Nitazoxanide Treatment for Giardiasis and Cryptosporidiosis in Children

OBJECTIVE To review the pharmacology, pharmacokinetics, adverse effects, drug interactions, dosing recommendations, and clinical efficacy of nitazoxanide, a new antiprotozoal/anthelmintic/antibacterial agent. DATA SOURCES A MEDLINE search (1966-February 2004) of both human and animal research data published in the English language was conducted. STUDY SELECTION AND DATA EXTRACTION All primary and review articles pertaining to the MEDLINE search were reviewed for inclusion. Emphasis was placed on randomized, double-blind, placebo-controlled trials. DATA SYNTHESIS Nitazoxanide is approved for the treatment of giardiasis and cryptosporidiosis (first drug approved for the latter indication) in immune-competent children <12 years of age. Most studies in immune-competent patients have reported clinical and parasitologic response rates close to 80% and 70%, respectively, for both indications. Response rates have been lower in immune-compromised patients. CONCLUSIONS Nitazoxanide should be available for patients unable to tolerate or adhere to first-line therapy employed for these intestinal protozoa. THIS ARTICLE IS APPROVED FOR CONTINUING EDUCATION CREDIT ACPE UNIVERSAL PROGRAM NUMBER: 407-000-04-014-H01
Statistical Analysis of Various Factors Affecting the Results of Cochlear Implantation

analysis of several factors was performed to reveal any significant effect of the outcome of the procedure. RESULTS: The duration of deafness in adults showed a significant linear yet non-monotonic correlation with the postoperative average auditory thresholds as revealed by Pearson’s correlation coefficient (r=0.839, p=0.009) and a linear regression model (f=14.211, p=0.009), which showed that the increase in the duration of deafness led to an increase in hearing thresholds and accounted for 70.3% of the variance in the outcome (β=0.839, t=3.770, and p=0.009). Age at implantation in children showed a positive linear, monotonic relation with the postoperative receptive (r=0.725, p<0.001, r S =0.354, p=0.010) and was a significant predictor of outcome (β=0.440, t=2.961; p=0.005) according to multiple linear regression. Mann-Whitney U-test was performed to evaluate the difference in medians of outcomes in relation to the regularity of attendance to speech rehabilitation. We found a significant effect over the auditory hearing thresholds (the mean ranks of regulars and irregulars were 21.48 and 31.92, respectively; u=202.00, z=2.48, p<0.05) CONCLUSION: An increase in the duration of deafness leads to less favorable results of postoperative auditory thresholds in postlingual adults. Additionally, an increase in age at implantation may be associated with increased expressive language age in the first year postimplantation, and regular attendance to a speech rehabilitation program is associated with better postoperative auditory thresholds and a higher receptive language age.
Susceptibility of Oriental Fruit Moth (Lepidoptera: Tortricidae) to Two Pyrethroids and a Proposed Diagnostic Dose of Esfenvalerate for Field Detection of Resistance

ABSTRACT Laboratory colonies of oriental fruit moth, Grapholita molesta (Busck) (Lepidoptera: Tortricidae), were reared on ‘Gala’ apples (Malus pumila Mill.) and lima bean (Phaseolus lunatus L.) diet. Neonates were placed on wheat germ diet containing a range of concentrations of esfenvalerate or lambda-cyhalothrin; mortality was assessed after 96 h. For a long-term laboratory colony, LC50 values of esfenvalerate and lambda-cyhalothrin were 0.35 and 0.12 ppm, respectively, for progeny of insects reared on apples. For a colony established from Calhoun Co., IL, in 2007, LC50 values of esfenvalerate and lambda-cyhalothrin were 0.37 and 0.10 ppm, respectively, for progeny of insects reared on apples. LC50 values of these insecticides did not differ significantly for either colony when progeny of insects reared on lima bean diet were tested. We observed no consistent evidence of pyrethroid resistance in the Calhoun colony after laboratory culture for 21–23 generations. We described the dose-response relationship for esfenvalerate applied topically in 1 µl of acetone to male moths from the long-term laboratory colony and estimated the LD99 to be 0.022 µg per moth. Application of 0.022 µg of esfenvalerate per moth to ≈ 600 male moths from two putatively susceptible populations resulted in mean survivorship approximately equal to the expected level of 1.0%. Application of the same dose to 374 field-captured moths from two Calhoun Co. orchards with histories of pyrethroid use resulted in mean survivorship of 9.4 and 82%. We propose that 0.022 µg of esfenvalerate in 1 µl of acetone can be used as a diagnostic dose for monitoring pyrethroid resistance in oriental fruit moth in the field.
Scrutinizing reference: how gesture and speech are coordinated in mother-child interaction

ABSTRACT Maternal estensive naming was investigated in a cross-sectional study of 12 children aged 0;10, 1;3 and 1;6, and a follow-up study of four children aged 1;3. Display, demonstration and pointing were coded with regard to whether and how co-occurring speech referred to gesture focus. Multivariate log-linear frequency analyses found that mothers' coordination of speech with gesture varied with age and the gesture used. Maternal naming of objects was most frequent with children aged 0; 10. Maternal gesture-speech coordination with children aged 1;3 and 1;6 differed in two related ways: (1) actions were named more frequently than objects; and (2) mothers often combined gesture with complementary speech referring, not to gesture focus, but to an action to be performed with the object indicated. At all ages, pointing was rarely used to name ostensively, and occurred most often in combination with complementary reference. Maternal input was found to be significantly correlated with children's reported receptive vocabulary.
Le code, les codac et la citoyenneté européenne

En France , la nationalite determine qui appartient et qui n'appartient pas a la nation , qui est citoyen et qui ne lest pas. Pourtant les derniers developpements du concept de nationalite la designent de plus en plus comme un espace de discrimination , insuffisant a garantir une egalite d'acces aux droits des citoyens. La Republique reconnait elle-meme les insuffisances du pari de l'integration republicaine : la creation des Codac (Commissions departementales d'acces a la citoyennete), chargees de prevenir les discriminations en fonction de l'origine des individus, en meme temps que de faciliter l'acces a la citoyennete touche directement a l'edifice de la nationalite 'a la francaise en echo des mutations a l'œuvre en Europe.
Glucose tolerance is improved after low- and high-intensity exercise in middle-age men and women.

We compared the effects of low- and high-intensity exercise on oral glucose tolerance immediately and 24 hr after each exercise bout. Participants were 5 male and 5 female individuals (age 40-48). A fasted, oral glucose tolerance test (OGTT) was conducted several days before the first exercise bout. Glucose and insulin concentrations were determined every 15 min throughout a 2 hr, 75 g OGTT. Immediately after low-intensity exercise, the incremental glucose area under the curve was reduced by 16%, compared to the fasting OGTT (p < .05). This was reduced further (-30%) 24 hr postexercise (p < .05). After high-intensity exercise, similar results were observed, with the incremental glucose area reduced by 14 and 35% immediately and 24 hr postexercise, respectively (p < .05). In conclusion, exercise improves glucose tolerance, this effect is more pronounced 24 hr postexercise, and low- and high-intensity exercise provide similar beneficial effects on glucose tolerance.
Diagnostic value of bedside tests (urine reagent strips and semi-quantitative procalcitonin (PCT-Q)) in the diagnosis of acute bacterial meningitis in Egyptian patients

Bacterial meningitis is a serious infection of the central nervous system. On the other hand, aseptic meningitis is a benign self-limited disease. Differentiating both diseases is of great importance. Earlier studies using urine reagent strips and procalcitonin (PCT) for diagnosis of meningitis had given a high sensitivity and specificity rates reaching 100%. The main aim of this study was to evaluate the usefulness of two bedside diagnostic tests in the diagnosis of meningitis. These were urine reagent strips and semi-quantitative procalcitonin (PCT-Q) test. One hundred patients with clinical and laboratory data suggesting of meningitis were included in this study. Complete biological and biochemical laboratory examination of cerebrospinal fluid (CSF), and serum inflammatory markers were done. According to this work, the 100 patients were classified into 64 patients with bacterial meningitis and 36 patients with aseptic meningitis. The CSF samples were tested using urine reagent strips for protein, glucose and leukocytes; as well as for PCT-Q test to detect its ability in differentiating bacterial from viral aseptic meningitis. Positive bacterial culture is the gold standard in the diagnosis of bacterial meningitis but it yielded a very low positivity rate (combined Gram stain and cultures were positive in only 4%). Although CSF protein concentration and leukocyte count and serum CRP were significantly higher in bacterial than aseptic meningitis, there was a wide area of overlapping results between the two groups. The number of reagent strip results coinciding with the laboratory results was 72%, 64% and 48% for leukocytes, protein and glucose respectively. Sensitivity rates were moderate and the degree of agreement between CSF strip and laboratory results were increased with higher grades for leukocytosis. PCT-Q had a good discriminating ability in differentiating bacterial from viral meningitis. With a cutoff value of 0.5 ng/dL, it was positive in 87% of patients with bacterial meningitis and negative in 91% of cases of viral aseptic meningitis. The use of reagent strips for the diagnosis of meningitis can be used only as a preliminary screening test till the laboratory results became available. PCT-Q test was more sensitive in differentiating bacterial from viral meningitis but it cannot be used alone for this diagnosis.
Conducta de sexting en adolescentes: predictores de personalidad y consecuencias psicosociales en un año de seguimiento

La relación entre el sexting y la personalidad en los adolescentes ha sido escasamente investigada. Además, es notoria la escasez de estudios longitudinales que aborden los predictores y consecuencias del sexting. Este estudio analiza los datos de 624 adolescentes que fueron evaluados en dos ocasiones (T1 y T2) distanciadas por un período de un año, y a los que se administraron cuestionarios para medir el sexting, los rasgos de personalidad del modelo de cinco factores (MCF), y posibles consecuencias psicosociales del sexting (acoso/ciberacoso, bienestar emocional). Los resultados indican que mayor extraversión y menor amabilidad y responsabilidad (T1) se relacionan con sexting (T2). El estudio permite también identificar qué facetas específicas de personalidad (T1) se asocian con el sexting registrado en T2. Además, los análisis de regresión muestran que la extraversión predice aumentos en sexting entre T1 y T2. En cuanto a las consecuencias, una alta implicación en sexting T1 predice descensos en la victimización y en las emociones positivas experimentadas entre T1 y T2. Por tanto, este estudio muestra que la personalidad permite predecir los cambios en sexting a lo largo de la adolescencia; el sexting, a su vez, parece asociarse a consecuencias psicosociales relevantes en este período del desarrollo. The relationships between personality and sexting have been scarcely studied. In addition, the scarcity of longitudinal studies about predictors and consequences of sexting is notorious. This study analyzed the longitudinal data from 624 adolescents who were evaluated on two occasions (T1 and T2) separated by a period of one year, and to whom questionnaires were administered to measure sexting, the personality traits of the five factor model (FFM), as well as possible psychosocial consequences of sexting. The results indicate that high extraversion and low agreeableness and conscientiousness (T1) are related to sexting (T2). In addition, the study also allows us to identify which specific facets of personality (T1) are associated with sexting registered in T2. On the other hand, regression analyses indicate that extraversion predicts increases in sexting between T1 and T2. As for the outcomes of sexting, a high involvement in sexting T1 predicts decreases in victimization and in the positive emotions experienced between T1 and T2. Therefore, this study shows that personality allows for prediction of changes in sexting throughout adolescence; sexting, in turn, seems to be associated with relevant psychosocial consequences in this developmental period.
Ketamine Inhibits Monoamine Transporters Expressed in Human Embryonic Kidney 293 Cells

Background Ketamine has been characterized as having psychotomimetic and sympathomimetic effects. These symptoms have raised the possibility that ketamine affects monoaminergic neurotransmission. To elucidate the relation between ketamine and monoamine transporters, the authors constructed three cell lines that stably express the norepinephrine, dopamine, and serotonin transporters and investigated the effects of ketamine on these transporters. Methods Human embryonic kidney cells were transfected using the Chen‐Okayama method with the human norepinephrine rat dopamine, and rat serotonin transporter cDNA subcloned into the eukaryotic expression vector. Using cells stably expressing these transporters, the authors investigated the effects of ketamine on the uptake of these compounds and compared them with those of pentobarbital. Results Inhibition analysis showed that ketamine significantly inhibited the uptake of all three monoamine transporters in a dose‐dependent manner. The Ki (inhibition constant) values of ketamine on the norepinephrine, dopamine, and serotonin transporters were 66.8 micro Meter, 62.9 micro Meter, and 162 micro Meter, respectively. Pentobarbital, a typical general anesthetic agent with no psychotic symptoms, did not affect the uptake of monoamines, however. Further, neither the glycine transporter 1 nor the glutamate/aspartate transporter was affected by ketamine, indicating that ketamine preferentially inhibits monoamine transporters. Conclusions Ketamine inhibited monoamine transporters expressed in human embryonic kidney cells in a dose‐dependent manner. This result suggests that the ketamine‐induced inhibition of monoamine transporters might contribute to its psychotomimetic and sympathomimetic effects through potentiating monoaminergic neurotransmission.
A Classification of Healthcare Social Network Analysis Applications

As the web, social networks and the internet of things permeated our daily life; a new perspective for understanding the complexity of our interconnectedness has become necessary. One approach that has predominantly proven useful in discovering hidden relationships, connections and trends of complex systems through mathematical and graphical techniques is Social Network Analysis (SNA). This approach has become increasingly appeling for Healthcare in particular as many of this domain’s problems examine systems with dynamic actors that interact with each other and exhibit emergent complex behaviors. However, due to their multiplicity, the application of SNA methodologies proves to be a complex and confusing endeavor. In an attempt to support the effort of applying SNA methodologies on Healthcare research problems, this paper offers firstly a categorization of SNA methodologies (structural and dynamic analysis), then inventories Healthcare SNA applications and classifies them into organizational and e-health related problems. The resulting categorization helps identify the Healthcare research problems most auspicious for SNA methodologies and should thus provide a guiding material of adequate SNA methodologies for a given Healthcare research problem.
LA EVOLUCIÓN DEL CONCEPTO DE SEXUALIDAD COMO UN PRECEPTO MORAL

La conducta sexual siempre ha maravillado al ser humano y la evidencia mas clara es el gran acervo de trabajos que existen sobre ella. La informacion que se ha generado, contiene tanto informacion biologica como cultural. Algunos de estos trabajos la han descrito con el objetivo de encontrar su origen, funcion y diversidad; mientras otros, intentan clasificarla, regularla, juzgarla y hasta enderezarla. Gracias a este rico legado de estudios, tambien podemos darnos cuenta como la sexualidad se ha involucrado directamente en la cultura y esta a su vez, ha sido modifica por diversas razones filosoficas, economicas y politicas. Los registros mas antiguos que se tienen sobre el control de esta conducta, datan desde la antigua Grecia y en su conjunto, revelan como la conducta sexual se fue institucionalizando para mantener un riguroso control sobre ella que perdura hasta nuestros dias.
Vildagliptin: novel pharmacological approach to treat Type 2 diabetes

Vildagliptin is an orally active inhibitor of the enzyme dipeptidyl peptidase-4. It prevents the inactivation of the gut hormone glucagon-like peptide-1, which results in increased endogenous levels of the hormone. This stimulates insulin secretion and inhibits glucagon secretion by increasing the glucose sensitivity of the pancreatic α- and β-cells. A large body of evidence shows that vildagliptin improves glycemic control in subjects with Type 2 diabetes. Thus, vildagliptin reduces hemoglobin (Hb)-A1c by 0.8–1.1% from baseline levels of 7.7–8.5% as monotherapy in Type 2 diabetes. Furthermore, vildagliptin reduces HbA1c when used in combination therapy with metformin, a thiazolidinedione, a sulfonylurea or insulin. Moreover, vildagliptin is well tolerated, the risk of hypoglycemia is low and body weight is not increased during the treatment. Therefore, vildagliptin represents a novel pharmacological therapy for Type 2 diabetes. Its main potential is as an add-on therapy to metformin in patients with insu.
Modélisation des traînées de condensation par interaction entre l'aérodynamique, la cinétique chimique et la microphysique

Dans le cadre des etudes portant sur l’impact de l’aviation sur le changement climatique, les trainees de condensation font partie des phenomenes presentant le plus d’incertitudes quant a leur role. Dans ce contexte, l’etude vise a mieux decrire les caracteristiques physico-chimiques du panache dans le champ proche d’un avion, celles-ci pouvant conditionner les proprietes des trainees de condensation formees.Pour cela, des simulations spatiales tridimensionnelles de type RANS ont ete realisees a l’aide du code CEDRE de l’ONERA, prenant en compte les processus microphysiques, les reactions chimiques, et l’ecoulement aerodynamique autour et dans le sillage d'une configuration realiste d'un avion de transport civil. Les modeles microphysiques integres permettent de decrire les processus d’activation des particules de suie et les processus de condensation et d’evaporation d’eau a leur surface.Une phase de validation du code a ete menee pour chacun des processus pris en compte, montrant un bon accord avec les donnees de la litterature. Des etudes de sensibilite ont egalement ete conduites afin d’evaluer l’impact des parametres atmospheriques et des caracteristiques des effluents sur les proprietes des cristaux de glace formes. L’augmentation de la teneur en soufre du carburant entraine un accroissement de l’activite des suies et aboutit a une distance d’apparition plus courte et une opacite plus elevee des trainees de condensation. Lorsque la quantite d’eau emise est suffisante, l’augmentation du nombre de suies ejectees entraine un accroissement de la concentration de glace, resultant en un fort accroissement de l’opacite et de la superficie de la trainee de condensation.