Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling and Analysis of Miniaturized Frequency-Selective Surface Based on 2.5-Dimensional Closed Loop With Additional Transmission Pole

The 2.5-dimensional closed loop is investigated to constitute a novel miniaturized frequency-selective surface (FSS) whose electric size of one unit cell is as small as 0.048 λ0 × 0.048 λ0. For miniaturization, two pairs of orthogonal split square rings are connected in series by four vias array in the FSS unit cell. Thus, this FSS exhibits polarized insensitivity for different incident angles. An equivalent circuit model is implemented to give a physical insight of the working mechanism of the proposed miniaturized FSS. Moreover, the transmission zero and transmission pole are discussed by the full-wave simulations and equivalent circuit model. The additional transmission pole can be used to improve the sharp frequency-selective performance of the proposed miniaturized FSS. The results show a good consistency between the simulation, modeling, and measurement.
Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to HIV‐1

Numerous antibodies have been identified from HIV‐1‐infected donors that neutralize diverse strains of HIV‐1. These antibodies may provide the basis for a B cell‐mediated HIV‐1 vaccine. However, it has been unclear how to elicit similar antibodies by vaccination. To address this issue, we have undertaken an informatics‐based approach to understand the genetic and immunologic processes controlling the development of HIV‐1‐neutralizing antibodies. As DNA sequencing comprises the fastest growing database of biological information, we focused on incorporating next‐generation sequencing of B‐cell transcripts to determine the origin, maturation pathway, and prevalence of broadly neutralizing antibody lineages (Antibodyomics1, 2, 4, and 6). We also incorporated large‐scale robotic analyses of serum neutralization to identify and quantify neutralizing antibodies in donor cohorts (Antibodyomics3). Statistical analyses furnish another layer of insight (Antibodyomics5), with physical characteristics of antibodies and their targets through molecular dynamics simulations (Antibodyomics7) and free energy perturbation analyses (Antibodyomics8) providing information‐rich output. Functional interrogation of individual antibodies (Antibodyomics9) and synthetic antibody libraries (Antibodyomics10) also yields multi‐dimensional data by which to understand and improve antibodies. Antibodyomics, described here, thus comprise resolution‐enhancing tools, which collectively embody an information‐driven discovery engine aimed toward the development of effective B cell‐based vaccines.
Hybrid approach using ant colony optimization and fuzzy logic to solve multi-criteria hybrid flow shop scheduling problem

In this paper, we propose to solve the hybrid flow shop scheduling problem with multiple criteria, by using an hybrid method. This latter consists on the one hand, to use a meta-heuristic based on ant colony optimization algorithm to generate feasible solutions and, on the other hand, an aggregation multi-criteria method based on fuzzy logic is used to assist the decision-maker to express his preferences according to the considered objective functions. The aggregation method uses the Choquet integral which allows us to take into account the interactions between the different criteria. Experiments based on randomly generated instances were conducted to test the effectiveness of our approach.
Effectiveness of a computer-tailored smoking cessation program: a randomized trial.

BACKGROUND From a public health perspective, prevention of cancer and cardiovascular diseases requires effective smoking cessation programs that can be used on a large scale. OBJECTIVE To test the effectiveness of a new computer-tailored smoking cessation program vs no intervention. METHODS Randomized controlled trial, in the French-speaking part of Switzerland, September 20, 1998, to December 31, 1999. Potential participants were randomly selected from a general population register and recruited by mail. Daily cigarette smokers who wished to participate (N = 2934) were randomized to either the program or no intervention. A mean of 1.5 times per 6 months, participants in the active arm received by mail a computer-tailored counseling letter based on their answers to a questionnaire and stage-matched booklets. The counseling letters were tailored to the participants' stage of change (categorized as precontemplation [no intention of quitting smoking in the next 6 months], contemplation [seriously considers quitting in the next 6 months], or preparation [has decided to quit in the next 30 days]), level of tobacco dependence, self-efficacy, and personal characteristics. The outcome measure was self-reported abstinence (no puff of tobacco smoke in the past 4 weeks) 7 months after entry into the program. RESULTS Abstinence was 2.6 times greater in the intervention group than in the control group (5.8% vs 2.2%, P<.001). The program was effective in "precontemplators" who were not motivated to quit smoking at baseline (intervention vs control, 3.8% vs 0.8%; P =.001) and was effective regardless of perceived difficulty in quitting smoking at baseline. CONCLUSIONS The program was effective in increasing smoking cessation rates. Because it can reach a large number of smokers, this program can substantially contribute to disease prevention at a population level.
Adjusting multiple model neural filter for the needs of marine radar target tracking

The paper presents the research on establishing neural models of target movement. The models are to be adjusted to General Regression Neural Network, as such a filter is a base for multiple model neural filter, which is currently under development. The research presented are a part of the research project “Development of radar target tracking methods with the use of multiple model neural filtering” financed by Polish Ministry of Science and the paper is one of the series. The main goal of the presented research was to examine if different manoeuvring dynamics can be defined as a neural model by a network parameters. The research was conducted with Monte Carlo simulation.
The state of the art in prediction of breast cancer relapse using cell-free circulating tumor DNA liquid biopsies.

In the last half-century, impressive developments in molecular and genetic techniques has provided us with powerful tools for evaluation and decision making in the diagnosis, treatment, and follow-up of breast cancer patients. Standard practice includes the use of estrogen (ER) and progesterone receptor expression levels to describe biological features and endocrine responsiveness, histological grade, Ki67, and molecular signatures to evaluate proliferation and chemotherapy sensitivity, amplification status of the oncogene HER2 to stratify patients for HER2-directed treatment, and BRCA1/BRCA2 mutation status along with other high penetrant genes for hereditary risk assessment. Still other biomarkers are under development, among which the analysis of cell-free circulating tumor DNA (ctDNA) is one of the most exciting.
Cervico-ocular reflex in the normal adult.

(1) The cervico-ocular reflex (COR) in humans was measured while the subjects (n = 10) stood on a rotatable platform in a dark room with the head fixed by a stationary biteplate. Eye movements were measured in response to active and passive rotations about a vertical axis. (2) The COR gain (i.e., horizontal eye movement/amplitude of body rotation) was as great as 22% at low frequency of body rotation (0.025 Hz). With increasing frequency (e.g., at 0.4 Hz) the gain decreased to about 2%. (3) The phase angle of the eye movement ranged generally between -80 and -240 degrees with an average response around -180 degrees. (4) During active rotation, the COR response was similar to the responses measured during passive body rotation. (5) The principal conclusion drawn is that in normal adult humans the COR does not aid in stabilization of the image on the retina during passive or active body rotations. A theoretical function for the COR is presented and discussed.
Overview of the IL‐1 family in innate inflammation and acquired immunity

The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More than any other cytokine family, the IL‐1 family is primarily associated with innate immunity. More than 95% of living organisms use innate immune mechanisms for survival whereas less than 5% depend on T‐ and B‐cell functions. Innate immunity is manifested by inflammation, which can function as a mechanism of host defense but when uncontrolled is detrimental to survival. Each member of the IL‐1 receptor and TLR family contains the cytoplasmic Toll‐IL‐1‐Receptor (TIR) domain. The 50 amino acid TIR domains are highly homologous with the Toll protein in Drosophila. The TIR domain is nearly the same and present in each TLR and each IL‐1 receptor family. Whereas IL‐1 family cytokine members trigger innate inflammation via IL‐1 family of receptors, TLRs trigger inflammation via bacteria, microbial products, viruses, nucleic acids, and damage‐associated molecular patterns (DAMPs). In fact, IL‐1 family member IL‐1a and IL‐33 also function as DAMPs. Although the inflammatory properties of the IL‐1 family dominate in innate immunity, IL‐1 family member can play a role in acquired immunity. This overview is a condensed update of the IL‐1 family of cytokines and receptors.
Inheritance of Bone Geometry in Inbred Mice : Consideration of an Important Reciprocal Relationship Between Bone Mass and Bone Quality

Introduction Reducing fracture risk is an important clinical objective given the mortality, disability, and cost associated with fragility fractures. Identifying the factors that define bone mass and bone quality is fundamental to understanding bone fragility. Although peak bone mass is largely genetically determined (Smith et al., 1973), the manner by which biomechanically-relevant geometric parameters are inherited is not well understood. Further, the influence of genetic background on the relationship between bone geometry and bone quality is not understood. The objectives of the current study were to assess the relationship between genetic background, bone geometry, and bone mechanical properties in A/J and C57BL/6J inbred mice and to determine how these properties were inherited in F1 offspring.
A peculiar prevalence of p values just below .05

In null hypothesis significance testing (NHST), p values are judged relative to an arbitrary threshold for significance (.05). The present work examined whether that standard influences the distribution of p values reported in the psychology literature. We examined a large subset of papers from three highly regarded journals. Distributions of p were found to be similar across the different journals. Moreover, p values were much more common immediately below . 05 than would be expected based on the number of p values occurring in other ranges. This prevalence of p values just below the arbitrary criterion for significance was observed in all three journals. We discuss potential sources of this pattern, including publication bias and researcher degrees of freedom.
Correction to "asymptotic state tracking in a class of nonlinear systems via learning-based inversion"

Describes a learning approach to asymptotic state tracking in a class of nonlinear systems. The tracking problem considered concerns the case when the tracking-error dynamics are described by a set of time-varying nonlinear differential equations, which are periodic in time with a known period. Our iterative update scheme is based on the specific property that the learning system tends to oscillate in steady state. In fact, our approach extends in a very natural manner the idea of the well-known iterative learning control for the case of finite-time tracking problems to the case of infinite-time asymptotic tracking problems. The best advantage of the proposed leaning approach is that it is computationally simple and does not require one to solve any complicated equations based on full system dynamics. We explore the conditions under which a periodic nonlinear system exhibits a steady-state oscillation. Our work also can be viewed to provide a learning-based solution to the input-state inversion problem. The generality and practicality of our work is demonstrated through rigorous performance analysis and simulation using a robot manipulator.
Notes on Eastern Armenian verbal paradigms

: The paper discusses two “hidden” semantic oppositions in the Armenian verbal system: both have no specific segmental markers but are manifested in the division of verbal forms into certain formal classes. In the first case, we deal with the the division into synthetic and periphrastic forms, which corresponds to the expression of the so-called "temporal mobility" (or the ability to express the opposition between present and past). In the second case, it is the morphological opposition between the basic verbal stem and the stem with an alternation. The choice of the alternating stem is related to the perfective semantics of the verbal form, so that one can speak of a general aspectual opposition of perfective and imperfective sets of forms in Armenian (not isolated in traditional analysis).
Transcatheter Cryoablation Part II: Clinical Utility

The first transcatheter cryoablation procedure in humans was performed at the Montreal Heart Institute in August 1998.1 A patient with recalcitrant rapid atrial fibrillation successfully underwent cryoablation of the atrioventricular (AV) node. As part of this initial case series, complete AV block was successfully produced in 10 patients acutely using double freeze/thaw cycles at an average temperature of –58.1 ± 5.4◦C. Eight of the 10 patients remained in complete AV block at 4 months. This initial study likewise demonstrated the feasibility of cryomapping and intracardiac ultrasound visualization of cryolesion growth. Importantly, no complication occurred. Since this initial description, the technology substantially improved. The refrigerant was modified to allow lower temperatures and faster freezing rates, larger electrode-tip sizes emerged, and innovative catheters of differing configurations were manufactured. Diverse clinical applications have since been explored, as indications continue to be refined. While concerns over long-term effectiveness in certain substrates linger, particularly with smaller electrode-tip catheters, cryoablation’s unique safety profile has remained consistent. Cryoablation has been extensively characterized as painless, associated with greater catheter stability, and safer around surrounding vasculature, producing homogenous lesions that are sharply demarcated, preserve ultrastructural tissue integrity, and have a low propensity for thrombosis.2–11 Herein, we review the global clinical experience with this technology thus far.
American Gastroenterological Association (AGA) Institute technology assessment on image-enhanced endoscopy.

This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute Technology Assessment on "Image-Enhanced Endoscopy. " It was approved by the Clinical Practice and Economics Committee on August 3, 2007, and by the AGA Institute Governing Board September 27, 2007.
Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci

Bitter taste perception in humans is mediated by receptors encoded by 25 genes that together comprise the TAS2R (or T2R) gene family. The ability to identify the ligand(s) for each of these receptors is dependent on understanding allelic variation in TAS2R genes, which may have a significant effect on ligand recognition. To investigate the extent of coding variation among TAS2R alleles, we performed a comprehensive evaluation of sequence and haplotype variation in the human bitter taste receptor gene repertoire. We found that these genes exhibit substantial coding sequence diversity. In a worldwide population sample of 55 individuals, we found an average of 4.2 variant amino acid positions per gene. In aggregate, the 24 genes analyzed here, along with the phenylthiocarbamide (PTC) receptor gene analyzed previously, specify 151 different protein coding haplotypes. Analyses of the ratio of synonymous and nonsynonymous nucleotide substitutions using the Ka/Ks ratio revealed an excess of amino acid substitutions relative to most other genes examined to date (Ka/Ks=0.94). In addition, comparisons with more than 1,500 other genes revealed that levels of diversity in the TAS2R genes were significantly greater than expected (π=0.11%; p<0.01), as were levels of differentiation among continental populations (FST=0.22; p<0.05). These diversity patterns indicate that unusually high levels of allelic variation are found within TAS2R loci and that human populations differ appreciably with respect to TAS2R allele frequencies. Diversity in the TAS2R genes may be accounted for by natural selection, which may have favored alleles responsive to toxic, bitter compounds found in plants. These findings are consistent with the view that different alleles of the TAS2R genes encode receptors that recognize different ligands, and suggest that the haplotypes we have identified will be important in studies of receptor‐ligand recognition. Hum Mutat 26(3), 199–204, 2005. © 2005 Wiley‐Liss, Inc.
Black History Month: a provocation and a timeline

Interest in collecting social work histories has gathered pace with collections held by the Social Work History Network in Edinburgh University and Kings College, and several writers offering historical accounts of the development of social work. Few systematic accounts exist that specifically track the history of social work and social work education for engagement with black lives and with black communities, though there exists a considerable body of literature from which this history can be gleaned, some rapidly going into attrition. Here, we set out a timeline through a black British history that charts significant events, key moments, landmarks and publications, and legislative and policy turns that have relevance to the story of social work education in the UK. The timeline offers a mere snapshot, but nevertheless a useful one, in prompting deeper exploration of context, analysis and interpretation. We have consulted widely in the development of this timeline and offer it here as our contribution to Black History Month 2018.
Detecting and Classifying Morphed Malwares: A Survey

In this era, most of the antivirus companies are facing immense difficulty in detecting morphed malwares as they conceal themselves from detection. Malwares use various techniques to camouflage themselves so as to increase their lifetime. These obscure methods cannot completely impede analysis, but it prolongs the process of analysis and detection. This paper presents a review on malware detection systems and the progress made in detecting advanced malwares which will serve as a reference to researchers interested in working on advance malware detection systems.
The value of serum CA 125 for the management of tubo-ovarian abscesses.

OBJECTIVE The aim of this study was to compare the value of CA 125, ESR and CRP in predicting the outcome of tubo-ovarian abscess (TOA) treatment and to investigate whether TOA treatment could be improved by following the dynamics of CA 125 serum levels. STUDY DESIGN This prospective study included 36 patients with unilateral TOA, confirmed on the basis of history and physical examination, laboratory findings, and ultrasound (US) investigation. Venous blood samples for estimation of serum CA 125, CRP, and ESR were taken on hospital admission and then every 5 days. On day 20, the success of treatment was evaluated by clinical and sonographical re-assessment, and the patients were divided into two groups: those with complete regression of the TOA and those with residual inflammatory disease. Statistical analysis was performed by nonparametric Mann-Whitney U-test with multiple regression. RESULTS On admission, CA 125 levels were increased (> 16.7 U/ml) in 32 patients (88.9%). The CA 125 level amounted to 55.7 U/ml on the average. A significant difference in CA 125 values between the above mentioned two groups was observed from day 10 of treatment onwards (p = 0.00015). On comparison of ESR, CRP, and CA 125, the latter had the highest predictive value for disease outcome after day 10 (p < 0.0011), while at the time of diagnosis, ESR proved more reliable in predicting the outcome. CONCLUSIONS The dynamics of serum CA 125 allow an objective evaluation of the course and outcome of TOA, in combination with clinical parametres and US investigation.
Novel mutations in the KCND3‐encoded Kv4.3 K+ channel associated with autopsy‐negative sudden unexplained death

Heritable arrhythmia syndromes, including Brugada syndrome (BrS) and idiopathic ventricular fibrillation (IVF), may serve as the pathogenic basis for autopsy‐negative sudden unexplained death (SUD) and sudden infant death syndrome (SIDS). Emerging evidence has linked perturbations in the transient outward current (Ito) conducted by the KCND3‐encoded Kv4.3 pore‐forming α‐subunit to BrS or IVF. However, the contribution of KCND3 mutations to autopsy‐negative SUD/SIDS is unknown. To investigate the potential association between KCND3 and SUD/SIDS, mutational analysis of KCND3 was conducted in 123 SUDS and 292 SIDS victims using polymerase chain reaction, denaturing high‐performance liquid chromatography, and direct sequencing. Overall, one SIDS case (<1.0%) and two SUDS cases (1.6%) harbored potentially pathogenic mutations in KCND3. The novel p.Val392Ile, p.Ser530Pro, and p.Gly600Arg mutations involved highly conserved residues and were absent in 1,560 reference alleles. Although the SIDS‐associated p.Ser530Pro mutation demonstrated a wild‐type (WT) electrophysiological phenotype when heterologously expressed, the SUDS‐associated p.Val392Ile and p.Gly600Arg mutations significantly increased peak current density at +40 mV in comparison with WT by 100.4% (P < 0.05) and 50.4% (P < 0.05), respectively. p.Val392Ile also slowed recovery from inactivation 3.6‐fold, indicating a mixed electrophysiological phenotype. This is the first report indicating that KCND3 may serve as a rare genetic substrate in the pathogenesis of SUDS but not SIDS cases. Hum Mutat 33:989–997, 2012. © 2012 Wiley Periodicals, Inc.