Miracle-dz/UniFAR-FTUs huggingface dataset:
TEMPAS - contribution à la qualité dans un système d'alertes contextualisées adaptable

Les besoins croissants continuels de la medecine et de la sante accentuent la necessite de systemes d'alertes medicales bien adaptes. Ces systemes d'alerte peuvent etre utilises par une variete de patients et d'acteurs medicaux. Ils devraient permettre de controler un large eventail de variables medicales. Nous proposons Tempas, un systeme d'alertes parametrees par les utilisateurs. Aux alertes detectees on associees deux indices de qualite. L'indice d'applicabilite qui exprime dans quelle mesure un patient est concerne par l'alerte, et l'indice de confiance qui exprime la fiabilite de l'alerte concernant la fraicheur des donnees utilisees lors de sa detection. Les indices de qualite associes a une alerte detectee se calculent grâce aux informations liees a une situation d'alerte parametree par l'utilisateur. Une situation d'alerte est definie a partir d'une composition de conditions d'activation. Une condition d'activation est construite a partir d'une valeur linguistique exprimant l'etat (par exemple temperature elevee) ou la tendance (par exemple tension systolique a la hausse) d'une entite observable (la temperature, la tension systolique, etc.). Lorsque la situation d'alerte est evaluee, le systeme utilise les connaissances preparees prealablement par les utilisateurs concernant les valeurs linguistiques. C'est-a-dire, quelle valeur linguistique represente le mieux une valeur quantitative sous un contexte specifique. Les alertes detectees pouvant etre nombreuses, nous definissons un politique de notification pour ne notifier que les alertes pertinentes dans le but de ne pas fatiguer les utilisateurs. D'abord les alertes sont filtrees a partir des indices de qualite. Parmi les alertes restantes, le systeme filtre par expressivite : choisir les tendances plus durables et les valeurs linguistiques les plus expressives. Ensuite, dans le cas d'alertes consecutives, le systeme ne garde que les alertes qui accomplissent les preferences des utilisateurs, comme celles dont l'indice d'applicabilite augmente. L'objectif final est de fideliser l'utilisateur au systeme d'alertes en lui fournissant un service de qualite. Il s'approprie le systeme en meme temps qu'il definit les situations d'alerte. Ainsi, il est capable de l'adapter lui-meme au contexte afin d'obtenir des alertes de meilleure qualite. L'adaptation est guidee par les indices de qualite utilises pour reduire les faux-positifs et faux-negatifs ainsi que pour controler la sur-notification d'alertes. Nous proposons de nous appuyer sur les systemes existants en apportant des fonctionnalites de dynamisme et d'evolution, ainsi que des facilites de parametrage et d'adaptation en temps reel au contexte d'utilisation afin d'exploiter au mieux les observations.
Keratinocyte-specific Expression of Fatty Acid Transport Protein 4 Rescues the Wrinkle-free Phenotype in Slc27a4/Fatp4 Mutant Mice*

FATP4 (fatty acid transport protein 4; also known as SLC27A4) is the most widely expressed member of a family of six long chain fatty acid transporters. FATP4 is highly expressed in enterocytes and has therefore been proposed to be a major importer of dietary fatty acids. Two independent mutations in Fatp4 cause mice to be born with thick, tight, shiny, “wrinkle-free” skin and a defective skin barrier; they die within hours of birth from dehydration and restricted movements. In contrast, induced keratinocyte-specific deficiency of FATP4 in adult mice causes only mild skin abnormalities. Therefore, whether the loss of FATP4 from skin or a systemic gestational metabolic defect causes the severe skin defects and neonatal lethality remain important unanswered questions. To investigate the basis for the phenotype, we first generated wild-type tetraploid/mutant diploid aggregates that should lead to rescue of any abnormalities caused by loss of FATP4 from the placenta. However, the skin phenotype was not ameliorated. We then generated transgenic mice expressing exogenous FATP4 either widely or specifically in suprabasal keratinocytes, and we bred the transgenes onto the Fatp4-/- background. Both modes of FATP4 expression led to rescue of the neonatally lethal skin defects, and the resulting mice were viable and fertile. Keratinocyte expression of an FATP4 variant with mutations in the acyl-CoA synthetase domain did not provide any degree of rescue. We conclude that expression of FATP4 with an intact acyl-CoA synthetase domain in suprabasal keratinocytes is necessary for normal skin development and that FATP4 functions in establishing the cornified envelope.
A Review: Energy Efficiency using Various Protocols in Wireless Sensor Networks

An operative and manageable network is always required to fulfill the many practical applications ranges from small scale industry to large scale power conserved environment tracking. In case of wireless sensor networks (WSNs), energy devastation of network node is a tremendous confrontation in the context of maximizing the lifetime span of the WSN. It will always be risky, very costly or in some cases even impossible to charge or replace the overexerted batteries because of the contentious nature of the network. There are many researches for designing energy efficient protocols while as actualizing the desirable WSN operation. We are focusing on many different schemes which are used to degrade the energy utilization factor of the sensing nodes. When we diagnosed the causes for energy dissipation by the nodes, we are able to classify energy efficient schemes such as topology control, duty cycling, control reduction, energy efficient routing and data reduction.
The rate of loss of T‐tubules in cultured adult ventricular myocytes is species dependent

In this study, we compared the rate of detubulation of adult mouse and rat ventricular myocytes over a 72 h culture period. The T‐tubule density was measured in the following two ways: (i) as whole‐cell capacitance in voltage‐clamped myocytes relative to cell area; and (ii) using di‐8‐ANEPPS staining and confocal microscopy. In adult rat ventricular myocytes, whole‐cell capacitance/area was significantly reduced from 47 ± 3 fF μm2 (mean ±s.e.m.; n= 16) in freshly isolated (control) cells to 36 ± 2 fF μm2 (n= 20) after 72 h in culture. The T‐tubular density, as assessed optically using di‐8‐ANEPPS staining, at 48 h was significantly reduced to 70 ± 7% (n= 14) compared with control cells. The T‐tubular density was further reduced after 72 h in culture to 43 ± 7% (n= 10) compared with control cells. In contrast, in mouse myocytes neither whole‐cell capacitance relative to cell area nor optical assessment of T‐tubules showed any significant reduction in capacitance/cell area or T‐tubule density after 72 h of culture. Expression of caveolin‐3 (CAV‐3) (a marker of T‐tubule development) was also measured, and a significant reduction was observed in CAV‐3 expression in rat myocytes at 48 (80 ± 5.5%; n= 6) and 72 h (66 ± 9.5%; n= 6) compared with control cells. The expression of CAV‐3 in mouse myocytes was not significantly reduced even at 72 h. When rat ventricular myocytes were paced in culture for 72 h they exhibited no significant improvement in T‐tubule density or CAV‐3 expression compared with non‐paced cultured cells. In rat myocytes, sarcomere length shortening was significantly reduced in myocytes cultured for 48 (4.96 ± 0.72%; n= 26) and 72 h (4.32 ± 0.80%; n= 26) compared with freshly isolated cells (7.12 ± 0.56%; n= 18). Mouse myocytes, after 24 h in culture, were unable to follow external pacing. These results suggest that detubulation in quiescent culture is slower in the mouse than the rat and that this loss of T‐tubules profoundly affects excitation–contraction coupling in rat myocytes.
Detecting Interactions between Behavioral Requirements with OWL and SWRL

High quality requirements analysis is one of the most crucial activities to ensure the success of a software project, so that requirements verification for software system becomes more and more important in Requirements Engineering (RE) and it is one of the most helpful strategies for improving the quality of software system. Related works show that requirement elicitation and analysis can be facilitated by ontological approaches and semantic web technologies. In this paper, we proposed a hybrid method which aims to verify requirements with structural and formal semantics to detect interactions. The proposed method is twofold: one is for modeling requirements with the semantic web language OWL, to construct a semantic context; the other is a set of interaction detection rules which are derived from scenario-based analysis and represented with semantic web rule language (SWRL). SWRL based rules are working with rule engines like Jess to reason in semantic context for requirements thus to detect interactions. The benefits of the proposed method lie in three aspects: the method (i) provides systematic steps for modeling requirements with an ontological approach, (ii) offers synergy of requirements elicitation and domain engineering for knowledge sharing, and (3)the proposed rules can systematically assist in requirements interaction detection. Keywords—Requirements Engineering, Semantic Web, OWL, Requirements Interaction Detection, SWRL.
Understanding Faculty to Improve Content Recruitment for Institutional Repositories

Institutional Repositories and the Adoption Problem An institutional repository (IR) is an electronic system that captures, preserves, and provides access to the digital work products of a community [1]. In a university setting, an IR may provide a place for faculty work, student theses and dissertations, e-journals, datasets and so on. Whatever the particular focus of the university IR, to be successful it must be filled with scholarly work of enduring value that is searched and cited.
Provjera mogućnosti predikcije bihevioralnih namjera nezaposlenih osoba pomoću načina suočavanja sa stresom i eksternalnog lokusa kontrole

Ispitivanje je provedeno u dvije podružnice Hrvatskog zavoda za zaposljavanje (Zagreb i Sibenik) na ukupno 396 nezaposlenih osoba. Svi ispitanici odgovarali su na isti upitnik koji je sadržavao skale važnosti dobivanja radnog mjesta (aspiracija) i ocekivanja dobivanja posla, skalu strategija suocavanja sa stresom (modificirana Lazarusova skala s 5 subskala), Bezinovicevu skalu eksternalnosti i skalu spremnosti na ponasanje (s cetiri subskale). Prije obrade podataka, iz uzorka su izbaceni svi ispitanici na koje nezaposlenost ne djeluje stresno (ocekivanja su veca od aspiracija) kako bi bili sigurni da strategije suocavanja opisuju upravo one osobe koje stres i doživljavaju. Na doživljaj stresa i odabir nacina suocavanja neposredno utjece procjena mogucnosti kontrole. U slucaju procijenjene niske mogucnosti kontrole odabiru se nacini suocavanja usmjereni na emocije dok se u situacijama s visokom mogucnocu kontrole odabire problemu usmjereno suocavanje. Pretpostavljeno je da ce osobe koje postižu vise rezultate na skali eksternalnosti u vecoj mjeri koristiti emocijama usmjerene strategije suocavanja sa stresom dok ce oni koji postižu niže rezultate cece koristiti problemu usmjereno suocavanje. Dobiveni rezultati su pokazali povezanost eksternalnosti sa strategijama mirenja sa sudbinom, pasivnog usmjeravanja na emocije te izražavanja emocija. Eksternalni lokus kontrole predstavlja uvjerenje osobe o tome da su njena ponasanja, uspjesi i neuspjesi te događaji oko nje izvan njene vlastite kontrole. U skladu s ranijim nalazima, pretpostavljeno je da ce osobe koje postižu niže rezultate na skali eksternalnosti pokazivati vecu spremnost na ponasanje usmjereno dobivanju stalnog radnog mjesta, no ova hipoteza nije potvrđena, odnosno nije pronađena nikakva povezanost. Iskazani nacini suocavanja sa stresom u svojoj osnovi sadrže percepciju pojedinca o tome koje strategije koristi u svom nastojanju da se suoci sa stresom. Pretpostavljeno je da ce osobe koje cece koriste problemu usmjerene strategije suocavanja pokazivati vecu spremnost na ponasanje usmjereno dobivanju stalnog radnog mjesta dok ce oni koji cece koriste emocijama usmjerene strategije pokazivati manju spremnost na ponasanje. Dobiveni rezultati pokazali su da se na osnovu poznavanja strategija suocavanja sa stresom izazvanih nezaposlenocu može predviđati spremnost na prihvacanje posla u drugom gradu te spremnost na uobicajene akcije usmjerene dobivanju stalnog radnog mjesta. Metodoloske nesavrsenosti provedenog istraživanja te nesuglasje s rezultatima nekih ranijih studija ukazuju na potrebu daljnjih provjera postavljenih hipoteza.
Immunosuppression for Organ Grafting Observations on Cyclosporin A

The gulf between clinical organ grafting and basic immunology has always been wide. Satisfactory organ grafting models in the laboratory that can be directly transferred to the clinic do not exist. Clinicians have used empirical treatment to obtain therapeutic effects for more than 15 years since the introduction of an immunosuppressive regimen of Azathioprine and corticosteroids. Schwartz & Damashek (1959) showed that treatment of rabbits with 6-mercaptopurine for 2 weeks prevented the production of antibodies against foreign protein injected at the commencement of treatment and the effect persisted beyond the period of treatment and was specific for the antigen given at the time of the drug. Although the results were variable and the drug toxic, 6-mercaptopurine also impaired the rejection of kidneys grafted between unrelated mongrel dogs (Calne 1960, Zukoski et al. 1960). A variety of thiopurines were investigated and Azathioprine was found to be most effective in the canine renal graft model (Calne 1961). Goodwin et al. (1962) reported prolongation of kidney allograft survival in patients treated with steroids. The combination of Azathioprine and steroids was adopted in clinical practice and resulted in the first therapeutically valuable kidney grafts. Now more than 30,000 kidneys have been transplanted, yet despite the introduction of numerous adjuncts to this basic immunosuppressive regimen results have changed little in the last 10 years. Renal allografts between siblings identical for the A and B MHC antigens have excellent long term survival. Although occasionally there is acute rejection, the outcome of these grafts is nearly as good as grafts between identical twins. Matching for the A and B loci has less prognostic significance in grafts from unrelated donors, but avoiding a positive cross-match in recipients
Hyperhomocysteinemia and thrombosis: an overview.

CONTEXT Homocysteine, a sulfur-containing amino acid, absent in natural diets, is a metabolic intermediary in transmethylation and transsulfuration reactions. Such reactions are essential to normal cellular growth, differentiation, and function. Excess homocysteine is associated with vascular disease and related disorders. OBJECTIVE To review homocysteine metabolism, the pathogenesis and classification of hyperhomocysteinemia, and the published literature investigating the association of homocysteine and methylenetetrahydrofolate reductase defects with arterial and venous thromboembolism and related disorders. The role of vitamin supplementation in patients with hyperhomocysteinemia is addressed. DATA SOURCES Published medical and scientific literature. Articles addressing the objectives were selected and reviewed. Pertinent studies and conclusions were summarized, grouped, and contrasted. CONCLUSIONS The association of hyperhomocysteinemia and arterial and venous thrombosis is controversial. Severe hyperhomocysteinemia is associated with atherosclerosis. The effect of mild hyperhomocysteinemia is less certain. Coinheritance of methylenetetrahydrofolate reductase defects and factor V Leiden is likely to increase the risk of venous thromboembolism. The association of methylenetetrahydrofolate reductase defects combined with no additional thrombophilic risk factors with venous thrombosis is less clear. High doses of folic acid to lower homocysteine levels might not be necessary.
Implications of the pH and temperature of diluted , cooled boar semen on fresh and frozen-thawed sperm motility characteristics

Implications of the pH and temperature of diluted, cooled boar semen on fresh and frozen-thawed sperm motility characteristics P.H. Purdy*, N. Tharp, T. Stewart, S.F. Spiller, H.D. Blackburn a USDA-ARS-National Center for Genetic Resources Preservation, National Animal Germplasm Program (NAGP), Fort Collins, CO USA b Department of Animal Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 USA
Generating Headlines with Recurrent Neural Networks

This report describes the implementation and evaluation of two natural language models using the machine learning technique deep learning. More specifically, two different models describing recurrent artificial neural networks (RNNs) were implemented, capable of generating news article headlines. One model focused on the generation of random (unconditioned) headlines, and the other one on the generation of headlines based (conditioned) on a given news article. Both models were then trained and evaluated on a data set of approximately 500,000 pairs of news articles and their corresponding headlines. The task of summarizing large bodies of text into smaller ones, while maintaining the key points of the original text, has many applications. Quickly and automatically obtaining condensed versions of for example medical journals, scientific papers, and news articles can be of great value for the users of such content. The unconditioned model, implemented using a multi-layer RNN consisting of LSTM cells, was able to produce headlines of moderate plausibility, a majority being syntactically correct. The conditioned model was implemented using two RNNs consisting of GRU cells in an encoder-decodernetwork with an attention mechanism, allowing the network to learn what words to focus on during headlining. Although the model managed to identify important keywords in the articles, it seldomly managed to produce meaningful sentences with them. We conclude that the techniques and models described in this report could be used to generate plausible news headlines. However, for the purpose of generating conditioned headlines, we think that additional modifications are needed to obtain satisfying results.
Teoria em Gerenciamento de Resultados

O presente trabalho contribui para a pesquisa em gerenciamento de resultados ao oferecer ao pesquisador um material que consolida os principais conceitos associados ao tema e as escolhas metodológicas realizadas por trabalhos brasileiros publicados nos primeiros sete anos de investigação sobre o assunto. Este artigo reúne a base conceitual da literatura em gerenciamento a partir da qual foram desenvolvidas as pesquisas brasileiras publicadas entre 2001 e 2007 em anais de congressos nacionais e periódicos de circulação nacional. São abordados neste material a definição e perspectivas na concepção da prática do gerenciamento, os incentivos a ela associados e as principais fontes de gerenciamento e proxies correspondentes. Estão contemplados os conceitos de accruals agregadas, accruals específicas, accruals operacionais, accruals totais, gerenciamento real e gerenciamento operacional. Este trabalho se concentra na apresentação das questões relacionadas à investigação da prática do gerenciamento através do uso de accruals e do uso do intervalo de pequenos lucros da distribuição de freqüência de resultados como proxy de gerenciamento. A ênfase nestas duas abordagens justifica-se pelo fato de que nos estudos brasileiros há uma predominância no seu uso. Nas pesquisas estrangeiras, conforme observa McNichols (2000), o uso das accruals como proxy de gerenciamento também é predominante. Os conceitos e métodos abordados encerram o que pode ser chamado da primeira fase da pesquisa em gerenciamento no Brasil.
Maternal influenza during pregnancy and risk of congenital abnormalities in offspring.

BACKGROUND The teratogenic effect of influenza viruses is currently being debated, and we examined the large population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) to study the possible association between maternal influenza and various congenital abnormalities (CAs). METHODS The 1980-1996 HCCSCA includes 22,843 newborns or fetuses with CAs, and 38,151 matched controls (newborn infants without any abnormalities). RESULTS In the case group, 1328 (5.8%) mothers had influenza at some time during their pregnancies compared to 1838 (4.8%) mothers in the control group (adjusted prevalence odds ratios [PORs], 1.3; 95% confidence interval [CI], 1.2-1.4). In the calculation of the adjusted PORs, the use of antifever drugs and maternal employment status were considered. When cases and their matched controls were compared, there was a higher prevalence of maternal influenza during the second and/or third month of pregnancy for the group of newborns with cleft lip +/- palate (adjusted POR, 3.2; 95% CI, 2.0-5.3), neural-tube defects (adjusted POR, 1.9; 95% CI, 1.1-3.3), and cardiovascular malformations (adjusted POR, 1.7; 95% CI, 1.3-2.3). However, a direct teratogenic effect from influenza viruses appears to be unlikely, and we suggest that the higher prevalence of the CAs indicated above can be explained mainly by fever, because this risk was reduced by the use of antifever drugs. Periconceptional folic acid supplementation also showed some preventive effect for these CAs. CONCLUSIONS The indirect teratogenic effect of maternal influenza during pregnancy may be restricted by appropriate medical treatment (e.g., antifever drugs) and periconceptional folic acid supplementation.
On the Computational Complexity of Positive Linear Functionals on C [0;1].

The Lebesgue integration has been related to polynomial counting complexity in several ways, even when restricted to smooth functions. We prove analogue results for the integration operator associated with the Cantor measure as well as a more general second-order #P -hardness criterion for such operators. We also give a simple criterion for relative polynomial time complexity and obtain a better understanding of the complexity of integration operators using the Lebesgue decomposition theorem
Relative Serializability: An Approach for Relaxing the Atomicity of Transactions

Serializability is too strong a correctness criterion and unnecessarily restricts concurrency. We use the semantic information of a transaction to provide different atomicity views of the transaction to other transactions. The proposed approach improves concurrency and allows interleavings among transactions which are nonserializable, but which nonetheless preserve the consistency of the database and are acceptable to the users. We develop a graph-based tool whose acyclicity is both a necessary and sufficient condition for the correctness of an execution. Our theory encompasses earlier proposals that incorporate semantic information of transactions. Furthermore, it is the first approach that provides an efficient graph-based tool for recognizing correct schedules without imposing any restrictions on the application domain. Our approach is widely applicable to many advanced database applications such as systems with long-lived transactions and collaborative environments.