Miracle-dz/UniFAR-FTUs huggingface dataset:
Twitter text mining for sentiment analysis on government’s response to forest fires with vader lexicon polarity detection and k-nearest neighbor algorithm

Opinions about the government’s response to forest fires have drawn many opinions from the community. One way for people to express their opinions is to use social media Twitter. This study conducted a sentiment analysis process on the government’s response to handling forest fires in Indonesia in 2019 with data sources from Twitter. The analysis was carried out on 6325 datasets written on Twitter on September 20, 2019, and then through the process of pre-processing, automating labeling and classification. The automate labeling process uses a Vader that automatically detects the negative or positive polarity of each data and then goes through the classification process using the KNN algorithm. The test results that were built using rapidminer tools showed an accuracy level of the KNN algorithm of 79.45%, the highest if compared to other classifier algorithms such as decision trees, naïve Bayes and random forests. The sentiment analysis process can almost run automatically without human touch because there is already automated labeling using Vader. Testing sentiment analysis related to the government’s response to forest fires can be analyzed using the KNN algorithm and lexicon polarity detection Vader can be done properly.
Value relevance of realized gains and losses on available-for-sale securities

Several studies reveal that net income has high value relevance, but once AFS securities gains and losses are realized, such a realization will affect the amount of net income reported. The purpose of this study is to investigate the effect of realized AFS securities gains and losses on firm value (FV). The present study used quarterly financial statements of banks listed at the Indonesia Stock Exchange from 2011 to 2017 and multiple regression analysis. The results of this study reveal that realized gains and losses on AFS securities have a negative effect on firm value, which means that realized gains and losses on AFS securities have value relevance. These findings imply that users of financial statements have considered realized gains and losses on AFS securities when they get information about net income.
Délivrance par ultrasons de chimiothérapie encapsulée dans des liposomes sono-sensibles : contrôle et dosage de la cavitation inertielle ultrasonore

L'application d'ultrasons sur une tumeur, ou des liposomes se sont accumules, permet potentiellement de liberer le medicament mais aussi d'en favoriser l'absorption dans les cellules. La cavitation inertielle ultrasonore est le phenomene pressenti pour la liberation sous ultrasons de medicament encapsule dans de petits liposomes solides. Elle est tres dependante des conditions experimentales et peut-etre intense et imprevisible. L'objectif principal du travail realise dans le cadre de cette these est de controler et quantifier la cavitation inertielle, pour induire le largage de medicaments encapsules dans des liposomes. Dans cette optique, une dose de cavitation inertielle (DC), basee sur le filtrage du bruit large bande emis lors de ce regime de cavitation, est mise au point in vitro pour suivre le largage de medicament encapsule. Sous divers regimes d'ultrasons pulses, la DC a ete validee en dosant chimiquement les radicaux hydroxyles generes lors de l'implosion des bulles. Les tests menes sur diverses formulations de liposomes contenant de la doxorubicine (dox) ont montres une haute correlation entre le taux de largage de dox et la DC permettant de conclure que la cavitation inertielle est impliquee dans ce largage. Le role de la temperature sur la production de radicaux hydroxyles et la liberation de dox a egalement ete explore. Les experiences realisees ont permis de selectionner les formulations les plus sensibles aux ultrasons pour les tester sur des rats implantes avec des tumeurs prostatiques. Apres plusieurs experiences in vivo menees avec differents dispositifs ultrasonores et formulations de liposomes, le benefice du traitement combine a pu etre demontre.
LB002ILLUMINATE-A, A PHASE 3 STUDY OF LUMASIRAN, AN INVESTIGATIONAL RNAI THERAPEUTIC, IN CHILDREN AND ADULTS WITH PRIMARY HYPEROXALURIA TYPE 1 (PH1)

PH1 is a rare genetic disorder characterized by hepatic oxalate overproduction, leading to recurrent kidney stones, nephrocalcinosis, progressive kidney failure, and multiorgan damage from systemic oxalosis. There are no approved pharmacologic therapies for PH1. Lumasiran is a subcutaneously-administered investigational RNAi therapeutic that targets glycolate oxidase to reduce hepatic oxalate production. We report the first results from the six-month, double-blind period of ILLUMINATE-A, a randomized, placebo-controlled Phase 3 study to evaluate lumasiran in patients with PH1. Key inclusion criteria: age≥6 years, 24hr urinary oxalate (UOx)≥0.70 mmol/24hr/1.73m2, confirmed PH1 diagnosis, eGFR≥30 mL/min/1.73m2. Randomization: 2:1; lumasiran (n=26), placebo (n=13). Dosing: 3 mg/kg monthly×3, then quarterly. Primary endpoint: percent change in 24hr UOx excretion from baseline to month (M) 6. Primary comparison: least square (LS) mean treatment difference in percent change from baseline (average of M3-6). Lumasiran led to a statistically significant percent reduction in 24hr UOx excretion compared to placebo: the LS mean change from baseline to M6 (average of M3-6) was −65.4% with lumasiran and −11.8% with placebo (LS mean difference: −53.5%; p=1.7 × 10−14). Subgroup analyses of the primary endpoint showed a consistent effect of lumasiran across age, baseline UOx, eGFR, and concomitant pyridoxine use. Lumasiran led to statistically significant improvements in all hierarchically tested secondary endpoints, including: proportion of lumasiran-treated patients that achieved normalization or near-normalization of 24hr UOx at M6 (84% vs 0% of placebo-treated patients, p=8.3 × 10−7), and percent change in plasma oxalate from baseline to M6 (average of months 3-6) (-39.5%, p=2.9 × 10−8). There were no serious or severe adverse events. The most common adverse events related to lumasiran were mild, transient injection site reactions. Lumasiran resulted in clinically meaningful, rapid, sustained, and statistically significant reductions in urinary and plasma oxalate levels compared to placebo during the six-month double-blind period. Lumasiran has a favorable safety profile.
Performance Comparison of Different Estimation Techniques of the External Load-torque applied on a PMSM using Direct Flux Control

This work presents a comparison between three classical observation techniques for the estimation of the external load-torque of a low power PMSM, namely an extended Kalman filter, an unscented Kalman filter and an H∞ filter. The aim of this paper is to define how the load-torque estimation behaves as a sensorless control technique is generating the angular position and speed signals of the electrical machine. The obtained results are evaluated in order to determine which filter is the most suitable to be implemented on an embedded system.
Two key events associated with a transposable element burst occurred during rice domestication

Transposable elements shape genome evolution through periodic bursts of amplification. In this study we exploited knowledge of the components of the mPing/Ping/Pong TE family in four rice strains undergoing mPing bursts to track their copy numbers and distribution in a large collection of genomes from the wild progenitor Oryza rufipogon and domesticated Oryza sativa (rice). We characterized two events that occurred to the autonomous Ping element and appear to be critical for mPing hyperactivity. First, a point mutation near the end of the element created a Ping variant (Ping16A) with reduced transposition. The proportion of strains with Ping16A has increased during domestication while the original Ping (Ping16G) has been dramatically reduced. Second, transposition of Ping16A into a Stowaway element generated a locus (Ping16A_Stow) whose presence correlates with strains that have high mPing copies. Finally, demonstration that Pong elements have been stably silenced in all strains analyzed indicates that sustained activity of the mPing/Ping family during domestication produced the components necessary for the mPing burst, not the loss of epigenetic regulation.
Electroconvulsive Therapy in the Shadow of the Gas Chambers: Medical Innovation and Human Experimentation in Auschwitz

summary:Six years after it was first introduced into psychiatry in 1938, electroconvulsive therapy (ECT) became the subject of criminal human experiments in Nazi Germany. In 1944, at the Auschwitz III / Monowitz camp hospital, the Polish Jewish prisoner psychiatrist Zenon Drohocki started experimental treatments on prisoners with an ECT device that he had constructed himself. According to eyewitnesses, Drohocki's intention to treat mentally unstable prisoners was soon turned into something much more nefarious by SS doctors (including Josef Mengele), who used the device for deadly experiments. This article provides an account of this important and little-known aspect of the early history of ECT, drawing on an extensive array of historical literature, testimonies, and newly accessible documents. The adoption of ECT in Auschwitz is a prime example of the "grey zone" in which prisoner doctors had to operate—they could only survive as long as the SS considered their work useful for their own destructive purposes.
Molecular Players in Preserving Excitatory-Inhibitory Balance in the Brain

Information processing in the brain relies on a functional balance between excitation and inhibition, the disruption of which leads to network destabilization and many neurodevelopmental disorders, such as autism spectrum disorders. One of the homeostatic mechanisms that maintains the excitatory and inhibitory balance is called synaptic scaling: Neurons dynamically modulate postsynaptic receptor abundance through activity-dependent gene transcription and protein synthesis. In the first part of my thesis work, I discuss our findings that a chromatin reader protein L3mbtl1 is involved in synaptic scaling. We observed that knockout and knockdown of L3mbtl1 cause a lack of synaptic downscaling of glutamate receptors in hippocampal primary neurons and organotypic slice cultures. Genome-wide mapping of L3mbtl1 protein occupancies on chromatin identified Ctnnb1 and Gabra2 as downstream target genes of L3mbtl1-mediated transcriptional regulation. Importantly, partial knockdown of Ctnnb1 by itself prevents synaptic downscaling. Another aspect of maintaining E/I balance centers on GABAergic inhibitory neurons. In the next part of my thesis work, we address the role of the scaffold protein Shank1 in excitatory synapses onto inhibitory interneurons. We showed that parvalbumin-expressing interneurons lacking Shank1 display reduced excitatory synaptic inputs and decreased levels of inhibitory outputs to pyramidal neurons. As a consequence, pyramidal neurons in Shank1 mutant mice exhibit increased E/I ratio. This is accompanied by a reduced
Percepción del proceso de formación por competencias y su relación con las prácticas empresariales: un caso de estudio

Las practicas profesionales son una forma de validar la pertinencia de los programas academicos, al evaluar el desempeno de los practicantes en entornos reales en donde se requiere la aplicacion del conocimiento adquirido; en este sentido, el presente articulo tiene como objetivo hacer un analisis acerca de la percepcion de las competencias desarrolladas por practicantes de Tecnologia en Produccion Industrial e Ingenieria Industrial, de una institucion universitaria de la ciudad de Medellin. Para tal efecto, se hizo un comparativo de la percepcion de estudiantes, docentes y empresas, en relacion con las competencias del Ser, el Saber y el Saber-Hacer, lo cual se complemento con la encuesta institucional desarrollada por la oficina de practicas de dicha institucion, a partir de una metodologia descriptiva con enfoque mixto, no experimental, transeccional – correlacional. Como resultado del estudio estadistico se rechazo la hipotesis planteada para los grupos de interes, lo cual implica que existen diferencias en la percepcion de estos, frente al desarrollo de competencias profesionales y su aplicacion en las organizaciones. Se resalta como conclusion, para la poblacion estudiada, la importancia de la relacion entre las competencias adquiridas en el proceso formativo y un adecuado desempeno en la practica profesional.
Bioluminescent Multi-Characteristic Opsin for monitoring visual cortical activity upon optical stimulation

Non-invasive detection of neural activity is important for the diagnosis of neurological diseases, evaluation of therapeutic outcomes, and collection of real-time feedback for stimulation based therapeutic approaches. In the case of vision loss, due to retinal degeneration, optic neuropathy, or enucleation of the eye, there is a need to map changes in visual cortical activity during disease progression and subsequent vision restoration by retinal, optic nerve or cortical stimulation. Existing technologies allow interrogation of neuronal circuits by both read and write activity, albeit with inherent limitations. Here, we present the development of bioluminescent multi-characteristic opsin (bMCO-11), which is comprised of a highly photosensitive ambient light-activatable domain and a Ca2+-sensitive bioluminescence reporter. The high quantum efficiency of bMCO-11 enables light activation and recording of cellular activity upon local as well as wide area optical stimulation. Furthermore, persistent Ca2+ influx was achieved by bioluminescence based cyclic activation of the opsin-domain of bMCO-11 by transporting the ions only into bMCO expressing cells. This allowed us to continuously monitor visual cortical activity in wild type and retinal degenerated mice, without requiring any additional external excitation source.
Anticoagulation therapy in Italy

Thromboembolic disorders are a leading cause of morbidity and mortality, affecting millions of people worldwide. A prompt instrumental and laboratory diagnosis of clinical events associated with thrombotic pathology, together with the clinical and laboratory surveillance of antithrombotic therapies are essential mechanisms for the correct management of patients with thrombosis impacting positively on their quality of life. In this review, the author will summarize the current organization of anticoagulant therapy in Italy, a country where thrombosis represents a significant health problem of great social relevance.
Développement de la modulation noradrénergique du système de contrôle de la respiration chez Rana Catesbeiana

Lung ventilation appears progressively during tadpole development, showing that neural circuits responsible for the control of breathing undergo an important reorganization during development. Since neuronal mechanisms contributing to the emergence of air breathing in this species are little known, we studied the effect of the noradrenergic modulation on in vitro brainstem preparations at different developmental stages from Rana catesbeiana. The results show that noradrenaline bath application increases the pulmonary frequency in pre-metamorphic tadpole and decreases it in more mature animals via a a-adrenergic receptors activation. This stage-dependent effect on fictive lung ventilation originates from a developmental change of the GABAergic/glycinergic pathways during the establishment of the chloride gradient. In a more physiological context, noradrenergic modulation contributes to the hypoxia central chemoreflex in amphibian.
Upper and Lower Bounds of Constrained Capacity in Diffusion-based Molecular Communication

This paper investigates upper and lower bounds for the constrained capacity of a diffusive molecular communication (MC) system in the case where the information is associated with the concentration of molecules released by the transmitter. The evaluation of channel capacity for the diffusive channel is an open problem in the context of MC. Here, two simple bounds of the constrained capacity are derived for a given number of input concentration levels. Numerical results are reported for binary and quadruple concentration-shift keying considering the Poisson and Gaussian distributions, which are two common approximations used to describe the statistics of the received signal. We show that for both the two statistical channel models the resulting bounds are tight and, therefore, this means that, at least for low modulation orders, it is not necessary to resort to numerical techniques or complicated analytical expressions to guess the capacity of the diffusive MC channel.
The Bitter the Taste, The Better is the Medicine: Is Caffeine the Answer to COVID-19?

Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. The virus is mainly transmitted through droplets generated when an infected person coughs, sneezes, or exhales. The firsthand reason for COVID 19 is upper respiratory dysfunction which allows the entry of viruses in the respiratory system and leads to severe problems in the human body. Thus, Bitter taste receptor, TAS2Rs on human airway smooth muscle (ASM) found in the respiratory system can play a big role in providing immunity against COVID-19. Activation of TAS2Rs by bitter agonists activates host defense pathways through calcium signaling. Cytokines storms is the another reason for COVID -19 that can be prevented by TAS2Rs because it can regulate natural killer cell-mediated cytotoxicity, chemokine signaling pathways, T cell receptor signaling pathways, TNF signaling pathways, and others. Since, we propose to utilize caffeine, the bitter agonists to stimulate the TAS2Rs, activating host defense mechanisms and also suppressing the cytokine storms due to its anti-inflammatory action, altogether leading to an ameliorated effects of COVID-19.
A Novel Warpage Reinforcement Architecture with RDL Interposer for Heterogeneous Integrated Packages

Over the past two decades, the multi-functions of portable electronic devices have a significant influence to change the daily life of people. To meet the requirements of short transmission path of signals, and high I/O counts, ultrathin packaging technology and novel packaging architectures are continuously progressed in accordance with the emergence of advanced technologies in global semiconductor industry. Currently, the architecture of fan out panel-level packaging (FOPLP) grows into the mainstream to meet the essentials of three-dimensional chip stacking and heterogeneous integration. Some researches suggested that the fine metal trace small than 5μm/5μm (line-width/spacing) has been carried out by using redistributed layer (RDL) first interposer technology. In the meanwhile, the package on package framework was introduced for connecting application processor and stacked memory chips, which have been gradually implemented the above-mentioned portable electronic devices. However, the warpage issue of the top and bottom packages are always a critical issue while assembled. In order to solve this issue, an additional reinforcement frame, integrated with RDL interposer is proposed to reduce its deformation caused by coefficient of thermal expansion (CTE) mismatch among the materials of packaging components. The design of reinforcement frame is 15 mm x 15 mm with a 12 mm x 12 mm cavity. There are 540 interconnections with a 300 gm of pitch at the periphery of the present package. To estimate the reliability of abovementioned novel package with efficiency, a non-linear process-oriented finite element analysis (FEA) is approached. In addition, the technique of equivalent material characteristics is also needed into FEA model to simplify the complexity of packaging structure. Finally, the better combinations to control the warpage of the present novel packaging structure through choosing the type of MUF. The warpage of packaging is obtained via the simulation methodology and provided as the designed guideline of related packaging architectures.
The Concept of Quality in Public Courtyards: Explanations and Analyses. Case Study: Mausoleum of Shah Ni’mat-Allah Vali

Quality is a highly esoteric concept which compels theorists to offer different explanations. Based on library resources, quality can be defined as an interaction between individuals and their environment, which is caused by a set of environmental components differing in each environment. This paper studied the concept of quality in public courtyards. The Mausoleum of Shah Ni’mat-Allah Vali, which provides a reasonable setting with four distinguished public courtyards was selected as the case study. Owing to traditional patterns and frameworks of Iranian architecture, these courtyards are immensely popular amongst Iranian scholars and architecture students, and a formal imitation of this pattern is prevalent, while the qualities of such spaces are often neglected. By employing a wide literature review, the different theories regarding dimensions and components of quality in public open spaces were categorized based on the year and author. In the Delphi panel, experts narrowed down the literature review and suggested that the main dimensions are Functional, Visual and Morphological, Experiential and Perceptual, Social and Ecological, each of which has several components. These components were achieved using the Delphi method. Moreover, the authors used the analytical hierarchy process (AHP) method to understand the importance and to prioritize the dimensions and components. Furthermore, by using questionnaires and interviews, this research analyses the public courtyards of the case study. Based on the results, individuals could perceive all the proposed components and dimensions of the research and consider them while labeling a place as a high-quality environment. This highlights the fact that individuals’ minds recognize the role of these components in the real-world, and consciously or unconsciously evaluating with the aim of discovering a place more pleasant, attractive, and with higher qualities.
Biostratigraphy of the Cistecephalus Assemblage Zone (Beaufort Group, Karoo Supergroup), South Africa

The late Permian (Lopingian) Cistecephalus Assemblage Zone (CiAZ) of the Karoo Supergroup in South Africa has recently been radiometrically-dated to range from 256 to 255 My. It encompasses approximately one million years of the late Wuchiapingian epoch, at a time when the ancient intra-continental lowlands of southern Gondwana had fully recovered from the end-Guadalupian mass extinction. The diverse Cistecephalus Assemblage Zone fauna is dominated by the small herbivorous dicynodonts Diictodon, Pristerodon and the molelike Cistecephalus, along with a range of larger dicynodont herbivores including Oudenodon, Aulacephalodon, Rhachiocephalus, Dinanomodon and rare Endothiodon. The attendant large carnivores include the gorgonopsians Aelurognathus, Rubidgea, and Smilesaurus, while smaller carnivores are represented by eutherocephalians (e.g., Ictidosuchoides, Ictidosuchops) and small gorgonopsians (e.g., Aloposaurus, Scylacocephalus). Of the parareptiles, the large-bodied taxon Pareiasaurus is most common, with the diminutive pareiasaurs Anthodon, Nanoparia, and Pumiliopareia making their first appearance. Lithostratigraphically, the biozone for the most part coincides with the arenaceous Oukloof and lower Steenkampsvlakte members in the western sub-basin and the equivalent Oudeberg and lower Daggaboersnek members in the east, where it reaches its maximum thickness of 300 m. The Cistecephalus Assemblage Zone thins westwards to 120 m at Teekloof Pass, and eastwards to approximately 100 m near the town of Fort Beaufort.