Miracle-dz/UniFAR-FTUs huggingface dataset:
EXPLORING ENGLISH FOREIGN LANGUAGE STUDENTS’ LEARNING STRATEGIES IN READING ELT MATERIALS

This research aimed to reveal the type of language learning strategies dominantly used by the learners and the least type of learning strategies used by the learners. There were 10 students who were taken as the sample of participants. They are students who officially enrolled in Academic Reading Class in the second semester of English Study Program of Teacher Training and Education Faculty (FKIP) Tanjungpura University in Academic Year 2016/2017. Questionnaire consisting of 40 statements was distributed for data collection which in turn were analyzed by using mean score calculation. The analysis of the data revealed that the mean score of metacognitive learning style was 4.0 which indicated that this type of learning strategy fell into the highest frequency used by the students. Meanwhile, the average score for cognitive strategies was 3.7 in which it is categorized as the second rank of the learning strategy mostly used by the learners. The analysis toward compensation strategy resulted 3.5 for the mean score, and the average score for affective and social strategy reached average at 3.1 and 3.0 respectively. By contrast, memory strategy is the least type of learning strategy used by the students, reaching the mean only at 2,9. Keywords: EFL, Language Learning Strategies, Reading, ELT Materials
A randomized, double-blind, placebo-controlled phase II study of prophylactic dexamethasone (dex) therapy for fatigue and malaise due to regorafenib in patient (pts) with metastatic colorectal cancer (mCRC): (KSCC1402/HGCSG1402).

10127Background: Regorafenib (REG) is an oral multikinase inhibitor with survival benefit in salvage line therapy for metastatic colorectal cancer (mCRC); fatigue and malaise which are common adverse events (AEs) cause REG treatment discontinuation. Oral steroids are empirically used for treatment of cancer related fatigue, although there is only a few evidence. KSCC1402/HGCSG1402 is a phase II, randomized, double-blind, placebo-controlled study evaluating the prophylactic effects of oral dex on REG-related fatigue and malaise for pts with mCRC. Methods: Eligibility included mCRC, objective failure of standard therapy, ECOG performance status 0 or 1. ≤ Grade 1 fatigue or malaise was allowed to be enrolled in this study. Pts were 1:1 randomly assigned to an oral steroids group (dex 2 mg/day, 4 weeks) or a placebo (PLC) group with REG (160 mg/day, 3 weeks on/1 week off). The protocol period was scheduled for first 28 days of REG treatment. The primary endpoint was incidence of fatigue or malaise (CTCAE ver.
Sneak Path Free Reconfiguration With Minimized Programming Steps for Via-Switch Crossbar-Based FPGA

Field programmable gate array (FPGA) that utilizes via-switches, which are a kind of nonvolatile resistive RAMs, for crossbar implementation is attracting attention due to higher integration density and performance. However, programming via-switches arbitrarily in a crossbar is not trivial since a programming current must be provided through signal wires shared by multiple via-switches. Consequently, depending on the previous programming status in sequential programming, unintentional switch programming may occur due to signal detour, which is called the sneak path problem. This article identifies the circuit status that causes the sneak path problem and proposes a sneak path avoidance method that gives sneak path free programming order of via-switches in a crossbar. We prove that sneak path free programming order necessarily exists for arbitrary ON-OFF patterns in a crossbar as long as no loops exist. This article also proposes a partial reconfiguration method that achieves the minimum number of switch programming steps while avoiding the sneak path problem. This method contributes to the extension of via-switch lifetime and fast reconfiguration of the via-switch FPGA. Experimental results show that the proposed partial reconfiguration method reduces the number of programmed switches by 77.4% compared to the conventional approach. This 77.4% reduction improves the number of reconfigurations of the via-switch FPGA by $4.4\times $ and reduces reconfiguration time by 77.4%.
Aortic Regurgitation Is Common in Ankylosing Spondylitis: Time for Routine Echocardiography Evaluation

OBJECTIVES: The aim of this study was to assess the prevalence of aortic regurgitation and any relation to disease activity and specific human leukocyte antigen (HLA)-B27 subtypes in patients with ankylosing spondylitis. METHODS: Transthoracic echocardiography was performed in 187 patients (105 men), mean age (SD) 50 (13) years, and mean disease duration 24 (13) years, and was related to demographic, clinical, radiographic, electrocardiographic, and laboratory data. RESULTS: Aortic regurgitation was found in 34 patients (18%; 95% confidence interval [CI], 12%-24%): mild in 24, moderate in 9, and severe in one. The prevalence was significantly higher than expected from population data. Conduction system abnormalities were documented in 25 patients (13%; 95% CI, 8%-18%), and significantly more likely in the presence of aortic regurgitation (P ¼ .005), which was related to increasing age and longstanding disease, and increased from w20% in the 50s to 55% in the 70s. It was also independently associated with disease duration, with higher modified Stoke Ankylosing Spondylitis Spine Score, and with a history of anterior uveitis. HLA-B27 was present in similar proportions in the presence vs absence of aortic regurgitation. For comparison, clinically significant coronary artery disease was present in 9 patients (5%; 95% CI, 2%-8%). CONCLUSION: Patients with ankylosing spondylitis frequently have cardiac abnormalities, but they more often consist of disease-related aortic regurgitation or conduction system abnormalities than manifestations of atherosclerotic heart disease. Because aortic regurgitation or conduction abnormalities might cause insidious symptoms not easily interpreted as of cardiac origin, we suggest that both electrocardiography and echocardiography evaluation should be part of the routine management of patients with ankylosing spondylitis. Keywords: Ankylosing spondylitis; Aortic regurgitation; Disease activity; Echocardiography; Electrocardiography
Estimating ground-level particulate matter concentrations using satellite-based data: a review

ABSTRACT Particulate matter (PM) is a widely used indicator of air quality. Satellite-derived aerosol products such as aerosol optical depth (AOD) have been a useful source of data for ground-level PM monitoring. However, satellite-based approaches for PM monitoring have limitations such as impacts of cloud cover. Recently, many studies have documented advances in modeling for monitoring PM over the globe. This review examines recent papers on ground-level PM monitoring for the past 10 years focusing on modeling techniques, sensor types, and areas. Satellite-based retrievals of AOD and commonly used approaches for estimating PM concentrations are also briefly reviewed. Research trends and challenges are discussed based on the review of 130 papers. The limitations and challenges include spatiotemporal scale issues, missing values in satellite-based variables, sparse distribution of ground stations for calibration and validation, unbalanced distribution of PM concentrations, and difficulty in the operational use of satellite-based PM estimation models. The literature review suggests there is room for further investigating: 1) the spatial extension of PM monitoring to global scale; 2) the synergistic use of satellite-derived products and numerical model output to improve PM estimation accuracy, gap-filling, and operational monitoring; 3) the use of more advanced modeling techniques including data assimilations; 4) the improvement of emission data quality; and 5) short-term (hours to days) PM forecasts through combining satellite data and numerical forecast model results.
Retrieval of cotton plant water content by UAV-based vegetation supply water index (VSWI)

ABSTRACT Knowing plant water content (PWC) is of great significance for precision irrigation of field crop. The aim of this study is to monitor the PWC of cotton non-destructively in situ. A six-band multispectral camera embedded on an unmanned aerial vehicle (UAV) was used to collect images at flowering and boll-forming stages of the cotton. Thirteen vegetation indices (VI) were extracted from the camera. Consequently, all the VIs were fused with canopy temperature mathematically into vegetation supply water indices (VSWI). Unary and multivariate models were used to establish the relationship between VSWIs and the water content of leaf, petiole, stalk as well as bud & boll, respectively. Results indicated significant correlations (P < 0.01) between the VSWI from green index (VSWI_GI) and leaf water content (LWC), and between the VSWI from MERIS terrestrial chlorophyll index by the second infrared band (VSWI_MTCI2) and bud & boll water content (BWC). The correlation coefficients between the stalk water content (SWC) and VSWI_MTCI2 as well as VSWI_DATT2 were both −0.895. The best retrieval model of LWC, SWC, and BWC were the multivariate linear models for the much higher estimation ability. Coefficients of determination for modelling and validation were close to or greater than 0.8, and the root-mean-square errors (RMSE) for validation were less than 0.17, and the relative errors (RE) were less than 18%. The results showed all these models have relatively high accuracy and can provide a new method to efficiently monitor water content in cotton plants.
Respiração lenta e profunda aumenta a modulação vagal em gestantes

OBJETIVOS: Comparar a resposta da modulacao autonomica da frequencia cardiaca de gestantes e mulheres nao gestantes, antes e apos a manobra de acentuacao da arritmia sinusal respiratoria. METODOS: Foi realizado um estudo transversal com amostra de 24 mulheres, divididas em dois grupos: grupo gestantes (independente da idade gestacional) e grupo controle (nao gestantes). A avaliacao consistiu em registro dos intervalos RR por um cardiofrequencimetro, para analise de indices lineares e nao lineares da variabilidade da frequencia cardiaca. As avaliacoes foram feitas no repouso em decubito lateral esquerdo, antes e apos a manobra de acentuacao da arritmia sinusal respiratoria, que consiste em respiracoes lentas de cinco a seis ciclos por minuto. A razao expiracao/inspiracao e a diferenca entre a inspiracao e a expiracao foram avaliadas durante a manobra. Foram comparados os resultados obtidos entre os dois grupos (gestantes e nao gestantes), assim como os obtidos em cada grupo, antes e apos a manobra. Para a analise estatistica o nivel de significância considerado foi p<0,05. RESULTADOS: Os indices lineares mostraram valores iniciais da modulacao simpatica (banda de baixa frequencia) aumentados nas gestantes quando comparadas as mulheres nao gestantes (gestantes: 68,9±28,1; controles: 49,3±11,7; p=0,002). Apos a manobra respiratoria, o indice obtido pela raiz quadrada da media do quadrado das diferencas entre os intervalos RR normais adjacentes aumentou no grupo gestantes (pre manobra: 34,5±5,7; pos manobra: 38,9±5,8; p=0,027), indicando aumento da atuacao parassimpatica para essa populacao apos a aplicacao da manobra. Alem disso, houve aumento dos valores de complexidade, sugeridos pela entropia de Shanon apos a manobra, para ambos os grupos, sendo o aumento maior nas gestantes. Em relacao aos indices avaliados durante a manobra, ambos os grupos apresentaram valores da razao expiracao/inspiracao maiores que 1, o que sugere integridade do sistema nervoso autonomo. CONCLUSOES: Houve melhora da regulacao do sistema nervoso autonomo ao final da manobra respiratoria para as gestantes, sugerindo que o padrao de respiracao lenta e profunda possa aumentar a modulacao vagal e conferir efeito cardioprotetor, alem de ocasionar relaxamento e sensacao de bem-estar.
Endocrine Disruptors and their Harmful Health Implications: Between Old Thoughts and New Findings

Recently, there is an increase in public and scientific communities’ attention concerning the effects of endocrine-disrupting chemicals on the reproductive and the endocrine systems. It is well known that the decline in human, livestock, and wildlife reproductive health is mainly caused by environmental pollution [1]. Many environmental chemicals, such as pesticides, have been experimentally demonstrated that they adversely affect the endocrine processes [2], known as endocrine disruptors (EDs). Endocrine disrupting chemicals are endocrine-modifying substances that have “weak intrinsic hormonal or anti-hormonal activity” [3] and affect the balance of normal hormonal functions [1,2]. Several studies regarding exposure to endocrine disruptors, specifically during prenatal and/ or postnatal growing stages, are published [4].
DyNet-LCCA: a simulation framework for dynamic network-level life- cycle cost analysis in evolving infrastructure systems

ABSTRACT Civil infrastructure systems transform over the long-term due to complex interactions among socio-environmental stressors, degradation of physical networks, and decision-making processes of infrastructure agencies. To incorporate such complex transformation mechanisms into infrastructure cost management, this study integrates simulation modeling and life-cycle cost analysis (LCCA) to create a framework for dynamic network-level LCCA in infrastructure systems. The proposed framework was implemented using a multi-agent simulation model in a numerical case study related to a road network affected by sea-level rise, population growth, and uncertain maintenance funding. The results include identification of several state transition, and tipping point behaviors at which small changes in service demand, maintenance budget, and adaptation investment may result in significant improvement in network cost and performance conditions. The results show the capability of the proposed framework in modeling the long-term trajectories of life-cycle costs at the network level under different stressors and decision scenarios.
Expression of CD146 on Human Placenta-Derived Mesenchymal Stromal Cells and their Osteogenic Differentiation Capacity are Modulated by Factors Contained in Platelet Lysate

Expression of CD146 on bone marrow-derived mesenchymal stromal cells (bmMSCs) is considered a marker for their multipotent differentiation potential and in situ localisation in the stem cell niche. We recently observed an elevated expression of CD146 on human bmMSCs upon expansion in medium enriched with platelet lysate. We therefore investigated if CD146 expression followed comparable paths on human placenta-derived mesenchymal stromal cells (pMSCs). In contrast to bmMSCs, pMSCs expanded in medium with platelet lysate expressed significantly less CD146 and failed to undergo osteogenic differentiation. We conclude that the expression of the stem cell marker CD146 on pMSCs and their osteogenic differentiation potential are modulated by factors contained in platelet lysate.
Tools for aiding in the diagnosis of neurodegenerative diseases

A system (100) and method for clinical evaluation of neurodegenerative disease present in a subject is described. The system (100) comprises an image acquisition module (122) operable to acquire image data representative of a brain of a subject, and an image analyser (124). The image analyser (124) is operable to determine a quantitative value from the image data that is indicative of the level of neurodegenerative disease present in the brain of the subject. Various embodiments of the invention provide a tool that aids in improved early diagnosis and monitoring of neurodegenerative diseases, such as, for example, Alzheimer's disease (AD).
Tratamiento de fisioterapia multimodal basado en un paradigma bioconductual en el abordaje de migraña crónica: Estudio de un caso.

La migrana cronica es una cefalea primaria en la que se producen mas de 15 episodios de cefalea al mes. Esta patologia es la septima causa de discapacidad en el mundo, y la literatura cientifica actual sugiere que un tratamiento multimodal desde un paradigma bioconductual se podria precisar para esta poblacion.Una mujer de 36 anos diagnosticada de migrana cronica que presento cefaleas 30 dias al mes y altos niveles de discapacidad. Se evaluaron mediante autoinforme kinesiofobia, pensamientos catastroficos, impacto del dolor de cabeza, discapacidad por migrana y niveles de ansiedad y depresion. Como variables motoras, la resistencia de los flexores profundos y finalmente se registro la frecuencia de dolor.Se tomaron cinco mediciones durante un total de 120 dias.Doce sesiones de tratamiento incluyendo terapia manual neuro-ortopedica, ejercicio terapeutico y estrategias bioconductuales, incluyendo educacion terapeutica en dolor fueron incluidos.El tratamiento multimodal basado en un paradigma multimodal produjo una reduccion sustancial en la frecuencia de las cefaleas, la discapacidad,
NK Cells Negatively Regulate CD8 T Cells to Promote Immune Exhaustion and Chronic Toxoplasma gondii Infection

NK cells regulate CD4+ and CD8+ T cells in acute viral infection, vaccination and the tumor microenvironment. NK cells also become exhausted in chronic activation settings. The mechanisms causing these ILC responses and their impact on adaptive immunity are unclear. CD8+ T cell exhaustion develops during chronic Toxoplasma gondii (T. gondii) infection resulting in parasite reactivation and death. How chronic T. gondii infection impacts the NK cell compartment is not known. We demonstrate that NK cells do not exhibit hallmarks of exhaustion. Their numbers are stable and they do not express high PD1 or LAG3. NK cell depletion with anti-NK1.1 is therapeutic and rescues chronic T. gondii infected mice from CD8+ T cell exhaustion dependent death, increases survival after lethal secondary challenge and reduces parasite reactivation. Anti-NK1.1 treatment increased polyfunctional CD8+ T cell responses in spleen and brain and reduced CD8+ T cell apoptosis. Chronic T. gondii infection promotes the development of a modified NK cell compartment, which does not exhibit normal NK cell behavior. This splenic CD49a-CD49b+NKp46+ NK cell population develops during the early chronic phase of infection and increases through the late chronic phase of infection. They are Ly49 and TRAIL negative and are enriched for expression of CD94/NKG2A and KLRG1. They do not produce IFNγ, are IL-10 negative, do not increase PDL1 expression, but do increase CD107a on their surface. They are also absent from brain. Based on the NK cell receptor phenotype we observed NKp46 and CD94-NKG2A cognate ligands were measured. Activating NKp46 (NCR1-ligand) ligand increased and NKG2A ligand Qa-1b expression was reduced. Blockade of NKp46 also rescued the chronically infected mice from death. Immunization with a single dose non-persistent 100% protective T. gondii vaccination did not induce this cell population in the spleen, suggesting persistent infection is essential for their development. We hypothesize chronic T. gondii infection induces an NKp46 dependent modified NK cell population that reduces functional CD8+ T cells to promote persistent parasite infection in the brain. NK cell targeted therapies could enhance immunity in people with chronic infections, chronic inflammation and cancer.
The Use Psychotropic Drugs among College Youth in India: An Appraisal

Through time and space, the use of mood-altering substances has been known to human societies (Taylor, 1966; Andrews, 1975). India, of course, has not remained untouched by this phenomenon (Kumarappa, 1952; Wilson, 1973). At various points of time, the drugs which have enjoyed a measure of popularity are alcohol, cannabis (including bhang, ganja and charas), opium and tobacco (Kurien, 1949). This is not to say that the use of intoxicants has always enjoyed social approbation. Buddhist, Jain, Muslim and even British rulers had attempted to curb or contain the use of intoxicating drugs (Kumarappa, 1952). In post-Independent India, the prohibition of 'intoxicating drinks and drugs' has been a na tional policy duly enshrined in the Constitution; and, as is well known, several states in the country have experimented with 'prohibition'. But all these attempts have had a somewhat indifferent success. Perhaps, in order to deal with the problem effectively, we need to look for alternative methods based on systematic study of drugs and drug users.
L'effet blouse blanche en médecine générale : étude nationale à partir d’une vignette clinique

Introduction : l’effet blouse blanche (EBB) est definie comme la presence d’une pression arterielle (PA) elevee en milieu medical et une PA normale en ambulatoire, sa prevalence est de 10-15%. Objectifs : etudier l’EBB aupres de medecins generalistes (MGs) francais et apprehender sa prise en charge en medecine generale. Methodes : un questionnaire electronique a ete envoye entre octobre 2017 et mars 2018, a 4057 MGs par les conseils departementaux de l’ordre des medecins. Le theme etait la prise en charge de l’hypertension arterielle (HTA) en medecine generale. La 1ere partie faisait reference a un cas clinique typique d'HTA et de questions associees. La 2nde traitee plus precisement de l’EBB et la derniere des donnees socio-demographiques. Resultats : parmi les 335 MGs inclus, 52% repondaient a une HTA et 48% a un EBB dans la 1ere partie. Dans la 2nde apres mesure ambulatoire de la PA et conclusion a un EBB les MGs ne mettaient pas en route de traitement. Ils traitaient cette patiente de la meme maniere quel que soit son risque cardiovasculaire global, et la revoyaient entre 3 et 6 mois. Une majorite des MGs etaient des femmes (52,5%), l’âge moyen etait de 41 ans, exercant de maniere egale en milieu rural ou urbain (58,2% contre 41,8%), en groupe mono disciplinaire (38,5 %). 59,4% avaient des activites universitaires, 51,6% pensaient qu’il n’y avait pas de recommandations concernant la prise en charge de l’EBB. Conclusion : l’utilisation de cette vignette clinique a permis de montrer que les recommandations pour la prise en charge de l’EBB sont encore trop peu connues et appliquees. Il est necessaire d'ameliorer la formation medicale continue et sensibiliser les patients.