Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemotherapy-induced nausea and vomiting

Cancer treatments and their side effects are often perceived as more debilitating than the actual cancer by many patients. Nausea and vomiting (NV) are still among the most common, expected, and feared side effects among patients receiving chemotherapy. In fact, some cancer patients who experience chemotherapy-induced nausea and vomiting (CINV) will delay chemotherapy treatments and contemplate refusing future treatments because of a fear of further NV. Anticipatory nausea and vomiting (ANV) are also problems among chemotherapy patients. By the fourth treatment cycle, anticipatory nausea has been reported in up to 30% of patients who experienced nausea following earlier chemotherapy cycles, while rates of anticipatory vomiting have been reported to be as high as 20%. CINV leads to poorer chemotherapy adherence, impaired functional activity, increased anxiety and depression, diminished quality of life (QOL), and increased utilization of healthcare resources, all of which substantially increase the burden of cancer and hinder its effective treatment. A great deal of progress has been made in the effective management of vomiting; however, nausea remains a substantial problem. The purpose of this article is to provide an overview of the pathopsychophysiology of CINV and the recommended guidelines for standard treatment, and to highlight newer targeted treatment approaches.
Efficient Structure-aware OLAP Query Processing over Large Property Graphs

Property graph model is a semantically rich model for real-world applications that represent their data as graphs, e.g., communication networks, social networks, financial transaction networks. On-Line Analytical Processing (OLAP) provides an important tool for data analysis by allowing users to perform data aggregation through different combinations of dimensions. For example, given a Q&A forum dataset, in order to study if there is a correlation between a poster’s age and his or her post quality, one may ask what is the average age of users grouped by the post score. Another example is that, in the field of music industry, it may be interesting to ask what total sales of records are with respect to different music companies and years so as to conduct a market activity analysis. Surprisingly, current graph databases do not efficiently support OLAP aggregation queries. In most cases, such queries are transformed to a sequence of join operations, and the system computes everything from scratch. For example, Neo4j, a state-of-art graph database system, processes each OLAP query in two steps. First, it expands the nodes and edges that satisfy the given query constraint. Then it performs the aggregation over all the valid substructures returned from the first step. However, in data warehousing workloads, it is common to have repeated queries from time to time. Computing everything from scratch would be highly inefficient. Materialization and view maintenance techniques developed in traditional RDBMS have proved to be efficient for processing OLAP workloads. Following the generic materialization methodology, in this thesis we develop a structure-aware cuboid caching solution to efficiently support OLAP aggregation queries over property graphs. Structure-aware means that our solution takes both heterogeneous attributes and graph topological information into consideration. The essential idea is to precompute and materialize some views based on statistics of history workload, such that future query processing can be accelerated. We implement a prototype system on top of Neo4j. Empirical studies over real-world property graphs show that, with a reasonable space cost constraint, our solution on average achieves 15-30x speedup over native Neo4j in time efficiency.
Glial S100A6 Degrades β-amyloid Aggregation through Targeting Competition with Zinc Ions

Evidence has been accumulating that zinc ions can trigger β-amyloid (Aβ) deposition and senile plaque formation in the brain, a pathological hallmark of Alzheimer’s disease (AD). Chelating zinc inhibits Aβ aggregation and may hold promise as a therapeutic strategy for AD. S100A6 is an acidic Ca2+/Zn2+-binding protein found only in a small number of astrocytes in the normal brain. However, in the AD brain, S100A6 is highly expressed in astrocytes around Aβ plaques. The role of the astrocytic S100A6 upregulation in AD is unknown. In the present study, we examined the effects of S100A6 on Aβ plaques and intracellular zinc levels in a mouse model of AD. Chronic exposure to zinc increased Aβ deposition and S100A6 expression, both reversible by the zinc chelator clioquinol, in the brains of amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice. To examine whether exogenous S100A6 could induce Aβ plaque disaggregation through competition for zinc in vitro, we incubated APP/PS1 mouse brain sections with recombinant human S100A6 protein or co-incubated them with human S100A6-expressing cells. Both treatments efficiently reduced the Aβ plaque burden in situ. In addition, treatment with exogenous S100A6 protected cultured COS-7 cells against zinc toxicity. Our results show for the first time that increased S100A6 levels correlate with both Aβ disaggregation and decrease of Aβ plaque-associated zinc contents in brain sections with AD-like pathology. Astrocytic S100A6 in AD may protect from Aβ deposition through zinc sequestration.
Oral serum bovine immunoglobulin improves IBS-D symptoms analyzed from patient medical charts.

Purpose: To examine clinical practice effectiveness of a medical food containing serum-derived bovine immunoglobulin (SBI) for the management of symptoms in irritable bowel syndrome with diarrhea (IBS-D) patients. Methods: From 165 IBS-D patient medical charts [mean age=59.6 years (range: 19-98), female (n=109), Caucasian (n=144)], recorded daily stools/consistency, abdominal pain, and patient/ physician reported quality of life (QoL) scores were retrospectively collected on those prescribed SBI for a minimum of 8 weeks. A generalized estimating equations model was used to analyze and compare changes for scores of symptoms and QoL. Results: Where data existed in charts, 46% of patients on SBI had a combined mean score reduction in daily stools, improvement in stool consistency (Bristol Stool Scale from >5 to <5) and decrease in abdominal pain (? 30%). Significant improvements (p<0.001) in individual symptom and QoL scores with a high response were also reported for daily stools (76%), consistency (78%), abdominal pain (69%), as well as patient (79%) and physician QoL (73%). Eleven patients experienced 13 adverse events (AEs) while receiving SBI with nausea (n=6) most prevalent. No serious AEs were reported, but 4 patients discontinued SBI. Conclusion: In this retrospective chart analysis of IBS-D patients who took a medical food containing SBI for 8 weeks, there were statistical improvements in daily stool number, stool consistency, abdominal pain and QoL scores supporting its use IBS-D.
Effect of Nutrition Counseling Knowledge and Attitude toward Mother Breast Feeding and Baby Growth in Sub Lubuk Pakam

To run the program exclusive breast milk, nursing mothers should have a good knowledge. One way to gain knowledge is to give nutritional counseling. This study Aimed to influence nutritional counseling on exclusive breast milk and Nutritional Status of the knowledge and attitude of nursing mothers in the district health centers Lubuk Pakam. This research is a quasi experiment nonequivalent control group design. Research work carried out in the region district health centers Lubukpakam (treatment group) and PHC Tanjung Morawa (the control group). The treatment group was given nutritional counseling intervention for 3 months given as many as three sessions. The study was conducted in March 2016 to August 2016. The results Showed prior to the intervention of knowledge in both groups did not Differ (p=0.290), after intervention were significantly different (p=0.000). While the average weight gain in infants in the first months of 1.25 kg treatment group, the control group of 1.19 kg and the second month 1.44 in the intervention group and the control group 1 kg. Based paired tests conducted indicate that there is influence nutritional counseling on knowledge and attitudes in the intervention group.
KECOMBRANG (Etlingera elatior): SEBUAH TINJAUAN PENGGUNAAN SECARA TRADISIONAL, FITOKIMIA DAN AKTIVITAS FARMAKOLOGINYA

Torch ginger (Etlingera elatior (Jack) R.M. Sm. ) has long been known by Indonesian people as an ornamental, vegetable, and traditional medicine. Rhizomes, stems, leaves, fruits, flowers and essential oils are part that is often used in daily life. The purpose of this review is to present a comprehensive information of traditionally using, chemical constituents, biological and pharmacological research as the scientific evidence of the torch ginger efficacy for further development of traditional medicine. Traditionally used of torch ginger indicates that it is widely used as a flavor enhancer in food, food preservatives, wounds and earaches medicine and body odor remover. Torch ginger is rich of phenols, polyphenols, flavonoids and terpenoids. The other research indicate that torch ginger has a wide range of pharmacological activity as an antioxidant, antibacterial, anticancer, larviciding and repellent. Abstrak Kecombrang ( Etlingera elatior (Jack) R.M. Sm. ) telah dikenal sejak lama oleh masyarakat Indonesia sebagai tanaman hias, sayur, dan obat tradisional. Rimpang, batang, daun, buah, bunga dan minyak atsiri merupakan bagian yang sering digunakan sehari-hari. Tujuan dari tinjauan ini adalah untuk menyajikan informasi yang komprehensif mengenai penggunaan secara tradisional, konstituen kimia, penelitian biologi dan farmakologi sebagai bukti ilmiah khasiat kecombrang guna pengembangan lebih lanjut dalam aspek pengobatan tradisional. Penggunaan secara tradisional menunjukkan kecombrang banyak digunakan sebagai penambah rasa pada masakan, pengawet makanan, mengobati luka dan sakit telinga serta sebagai penghilang bau badan. Kecombrang kaya akan golongan fenol, polifenol, flavonoid, dan terpenoid. Beberapa hasil penelitian menunjukkan kecombrang memiliki berbagai macam aktivitas farmakologis sebagai antioksidan, antibakteri, antikanker, larvasida dan repellent .
Congenital hepatic fibrosis in Holando Argentino calf: first report in Argentina

A case of congenital hepatic fibrosis in a 10-month-old calf is described. The calf had been raised in a feed lot for the past 173 days and exhibited loss of body condition and depression, followed by death. The most remarkable macroscopic lesions observed during necropsy were: jaundice, hepatomegaly with a multilobulated liver surface and diffuse pale brown colour of the parenchyma. Microscopically, the portal tracts were thickened and connected to each other by abundant fibrous tissue, delimiting irregular lobules of hepatocytes and occasional fibrosis of the central veins (perisinusoidal scars) and hyperplasia of embryonal bile ducts. Immunohistochemistry staining of the cytoplasm of the bile ducts was positive to AE1/AE3 and cell proliferation nuclear antigen (PCNA). The findings at necropsy, together with the results of the histopathological and immunohistochemistry studies, confirmed the diagnosis of congenital hepatic fibrosis.
HEALTH-SEEKING BEHAVIORS OF WOMEN WITH ADVANCED BREAST CANCER IN SOUTHWESTERN NIGERIA

: Globally, breast cancer is second most common cancer. Breast cancer is the most common cancer in women. It is the second cause of cancer-related mortality in women in high-resource income regions after lung cancer, and the most common cause of cancer-related deaths in women in low and middle-resource income regions. The leading cause of malignancy-related mortality among Nigerian women is breast cancer. In Southwestern Nigeria, women typically present with advanced stages of the illness, making the survival rate very low (48%). The aim of this study was to explore the women’s health-seeking behavior from their perspective. This research was a qualitative study guided by a constructivist naturalistic orientation to knowledge development. The methodological approach adopted for the study was the interpretive description (ID). The study participants were thirty women with advanced stages of breast, defined as stages III and IV. The study setting was a large, tertiary, and referral hospital in Southwestern Nigeria. Data were collected through one-on-one, semi-structured audio-recorded, interviews guided by open-ended questions and from a demographic information form individual participant completed in advance. Data analysis of interview transcripts were inductive. Descriptive statistics were used to illustrate the study participants’ characteristics. Findings revealed the study participants’ health-seeking behaviors and the factors the women believe influence their health-seeking activities. Methodologically, this study advances the use of a qualitative approach to inquiry in seeking to explore and understand the health-seeking behaviors of women with advanced breast cancer in Southwestern Nigeria, a subject on which empirical literature is scarce. interview suitability breast oncologists the
Clinical presentation and diagnostics of cattle with suspected Johne’s disease

Johne’s disease, caused by the bacteria Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic, wasting condition of ruminants, which is characterized by the clinical signs of weight loss and diarrhoea. The economic losses associated with the disease in the cattle and sheep industry, worldwide spread and high prevalence make Johne’s disease an important disease to investigate. Additionally, MAP has been isolated from humans suffering of Crohn’s disease and zoonotic potential of MAP in humans is still under debate. Currently available diagnostic tests have impaired sensitivity, particularly in preclinical stages of disease and thus a prompt and effective identification of infected animals is difficult. The primary aim of this work was to analyse and describe the history, clinical presentation and diagnostic test results of cattle submitted to a veterinary teaching hospital that showed clinical signs consistent with Johne’s disease. The secondary aim was to compare diagnostic test results to the gold standard, faecal culture. Fifty-nine out of the 192 cattle referred over 18 months met the inclusion criteria for the study, which was poor body condition or a history of weight loss and diarrhoea. A total of 52 females and seven males, comprising 34 beef and 25 dairy cattle were studied. All cattle had a full clinical examination, biochemistry blood analysis, Johne’s blood serology and faecal PCR and culture. They were inspected post-mortem and the ileo-caecal valve and proximal lymph node were examined histopathologically using a haematoxylin-eosin (H/E) and Ziehl-Neelsen (ZN) staining. Results from clinical examination, albumin and globulin serum concentrations, Johne’s serology, PCR, post-mortem examination and histopathology examination were compared to faecal culture results. Thus, this study reported all the clinical and diagnostic test results commercially available for Johne’s disease in cattle, such study was not reported before. Results showed inconsistent results between PCR and culture tests. However, both blood serology and H/E slide examination tests had a specificity of 100%. This work should help inform clinicians on interpretation of Johne’s diagnostic testing in clinical cases and may have implications for Johne’s control programmes relying on the results from the diagnostic tests reported.
Low serum adiponectin level is associated with central arterial stiffness in patients undergoing peritoneal dialysis

Objective: Adiponectin has antidiabetic, anti-atherosclerotic, and anti-inflammatory functions and protects against vascular damage. Carotid-femoral pulse wave velocity (cfPWV) is a noninvasive method for measuring central artery stiffness, which is known to be associated with cardiovascular disease in peritoneal dialysis (PD) patients. This study was conducted to evaluate the relationship between central arterial stiffness and serum adiponectin levels in PD patients. Materials and Methods: Fasting blood samples were obtained from 60 PD patients, and the cfPWV value was measured using a validated tonometry system. In this study, cfPWV values of >10 m/s were used to define the high arterial stiffness group according to the European Society of Hypertension and the European Society of Cardiology guidelines. Results: Among 60 patients with PD, 19 patients (31.7%) were included in the high arterial stiffness group. When compared to those in the control group, the high arterial stiffness group patients were older (P = 0.029), had longer PD vintage (P = 0.001), higher diastolic blood pressures (P = 0.030), higher fasting glucose (P = 0.014), and lower serum adiponectin levels (P = 0.001). After multivariable logistic regression analysis, serum adiponectin (odds ratio, 0.612; 95% confidence interval: 0.426–0.879; P= 0.008) was identified as an independent predictor of arterial stiffness. The multivariable regression analysis also showed that the adiponectin level (β = −0.408; adjusted R2 change = 0.183; P< 0.001) was negatively associated with cfPWV values in patients undergoing PD. Conclusion: Low serum adiponectin level is an independent marker of arterial stiffness in patients undergoing PD.
Risk Stratification for Sudden Cardiac Death in Heart Failure

Heart failure (HF) is a complex clinical syndrome in which structural / functional myocardial abnormalities result in symptoms and signs of hypoperfusion and/or pulmonary or systemic congestion at rest or during exercise. More than 80% of deaths in patients with HF recognize a cardiovascular cause, with most being either sudden cardiac death (SCD) or death caused by progressive pump failure. Risk stratiﬁcation of SCD in patients with HF represents a clinical challenge. This review will give an update of current strategies for SCD risk stratiﬁcation in HF.
Absorbed Dose Evaluation in Radioiodine Therapy with Different Approaches

The main approach to differentiated thyroid cancer (DTC) therapy is still empiric, consisting of the administration of fixed activities. Repeated treatments, however, may have a stunning effect. An individualized dosimetric study may represent an important tool to determine the best activity to prescribe, in particular for patients with distant metastases or when therapy with recombinant human thyroid-stimulating hormone (rhTSH) stimulation is deemed necessary. This study provides a practical operational example for carrying out a dosimetric study, according to the European Directive EURATOM/59/13. Starting from the case of a patient who underwent rhTSH stimulation before radioiodine ablation, we illustrate the necessity of measuring both red marrow (RM) and blood (BL) absorbed dose during the treatment in order to not exceed the dose limit of 2 Gy to the RM, so as to avoid repeating radioiodine treatment several times. Dosimetry to the RM and BL was performed during the treatments, after administration of therapeutic activity without modifying the fixed activity schema, using different approaches. The results suggest the possibility of restricting the number of treatments, reducing thus the risk of stunning effect and, where possible, eliminating an additional source of stress and dejection for patients.
Molecular regulation of arteriovenous endothelial cell specification

The systemic circulation depends upon a highly organized, hierarchal blood vascular network that requires the successful specification of arterial and venous endothelial cells during development. This process is driven by a cascade of signaling events (including Hedgehog, vascular endothelial growth factor (VEGF), Notch, connexin (Cx), transforming growth factor-beta (TGF- β), and COUP transcription factor 2 (COUP-TFII)) to influence endothelial cell cycle status and expression of arterial or venous genes and is further regulated by hemodynamic flow. Failure of endothelial cells to properly undergo arteriovenous specification may contribute to vascular malformation and dysfunction, such as in hereditary hemorrhagic telangiectasia (HHT) and capillary malformation-arteriovenous malformation (CM-AVM) where abnormal vessel structures, such as large shunts lacking clear arteriovenous identity and function, form and compromise peripheral blood flow. This review provides an overview of recent findings in the field of arteriovenous specification and highlights key regulators of this process.
The Hand Hygiene And Bacterial Colonies Count Of ICCU’ Visitors Hands: As An Indicator For Nosocomial Infection Prevention

Latar belakang: Infeksi nosokomial diperoleh dan ditransmisikan ke pasien yang dirawat di rumah sakit melalui kontak langsung dengan tangan. WHO menjelaskan bahwa intervensi yang paling efektif dan ekonomis untuk mencegah infeksi nosokomial adalah dengan mewajibkan prosedur mencuci tangan. Tujuan: Penelitian ini bertujuan untuk mendeskripsikan jumlah dan jenis koloni bakteri sebelum dan sesudah prosedur mencuci tangan, selanjutnya untuk mengetahui perbedaan jumlah dan jenis koloni bakteri pada sebelum dan sesudah prosedur mencuci tangan. Metode: design penelitian ini adalah quasi-eksperimen dengan satu kelompok pretest-posttest. Partisipan penelitian ini adalah pengunjung Unit Perawatan Intensif Kritis (ICCU) Rumah Sakit Advent Bandung. Partisipan direkrut menggunakan metode convenience sampling. Penelitian ini menggunakan 10 sampel dan data dianalisis menggunakan perangkat lunak SPSS. Hasil: Rata-rata jumlah bakteri sebelum mencuci tangan adalah 73,40 sel / cm2, dan rata-rata jumlah bakteri pada setelah mencuci tangan adalah 12,50 sel / cm2. Staphylococcus Sapropytuicus, Bacillus sp. dan Staphylococcus epidermis juga ditemukan di tangan pengunjung. Hasil uji paired t-test menunjukkan bahwa terdapat perbedaan yang signifikan antara jumlah koloni bakteri sebelum dan sesudah prosedur mencuci tangan dengan nilai p=0,002. Kesimpulan: Hasil penelitian ini adalah bukti yang valid bagi pengambil keputusan di rumah sakit untuk mempromosikan keberlanjutan kebijakan mencuci tangan sebagai bagian dari peningkatan kualitas asuhan keperawatan dan pada saat yang sama mempromosikan program pencegahan infeksi nosokomial dan keselamatan pasien.
Cervical cancer stem cells and other leading factors associated with cervical cancer development

Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus (HPV) infection. It has been well established that cancer stem cells (CSCs) play an important role in defining tumor size, the speed of development and the level of regression following treatment; therefore, CSCs are associated with a poor prognosis. CSCs have been detected in many types of cancer, including leukemia, pancreatic, colon, esophagus, liver, prostate, breast, gastric and lung cancer. In cervical cancer, CSCs have been associated with resistance to normally used drugs such as cisplatin. The present review summarizes the strategies that high-risk HPV viruses (HPV-16 and HPV-18) have developed to transform normal epithelial cells into cancer cells, as well as the cellular pathways and studies associated with the identification of cervical cancer stem cell biomarkers. In this sense, the present review provides state of the art information regarding CC development.