Miracle-dz/UniFAR-FTUs huggingface dataset:
Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies

Background: During the last decades, a huge body of evidence has been accumulated suggesting that Citrus fruits and their juices might have a role in preventing many diseases including cancer. Objective: To summarize the numerous evidences on the potential of Citrus juices and their extracts as anticancer agents. Data sources: A systematic review of articles written in English using MEDLINE (1946-present), EMBASE (1974-present) and Web of Sciences (1970-present) was performed independently by two reviewers. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, cancer, neoplasm, neoplasia, tumor, metastasis, carcinogenesis, proliferation. The last search was performed on March 16th, 2017. Study selection: Study selection and systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Prior to the beginning of the review, Authors defined a checklist for inclusion criteria, thus including articles which meet the following: (i) published on peer-reviewed scientific journals; (ii) Citrus juice used alone; (iii) extracts derived from Citrus juice; (iii) for preclinical studies, an exposure time to Citrus juices and their extracts more than 24 h. Reviews, meta-analyses, conference abstracts and book chapters were excluded. Data extraction: Three reviewers independently performed the extraction of articles. Data synthesis: 22 papers met our inclusion criteria and were eligible for inclusion in the final review. According to the kind of study, the selected ones were further divided in preclinical (n = 20) and observational (n = 2) studies. Conclusion: The studies discussed in this review strongly corroborate the role of Citrus juices and their derivatives as potential resource against cancer.
High Performance Datafly based Anonymity Algorithm and Its L-Diversity

Data anonymity, as an effective privacy protection method, has been widely used in real applications. High performance data anonymity algorithm is especially attractive for those massive data applications. In this paper, the authors propose a novel and efficient Datafly based data anonymity Divide-Datafly algorithm and the experimental results show that the proposed algorithm is not only more efficient than Datafly and Incognito, but also information loss less than KACA. Moreover, in order to improve the security of anonymous data, L-Divide-Datafly is presented that it combines Divide-Datafly and efficient distance based clustering. Experimental results show that L-Divide-Datafly achieves great performance both in execution time and Information loss.
Adaptive tracking control of leader-following linear multi-agent systems with external disturbances

ABSTRACT In this paper, the consensus problem for leader-following linear multi-agent systems with external disturbances is investigated. Brownian motions are used to describe exogenous disturbances. A distributed tracking controller based on Riccati inequalities with an adaptive law for adjusting coupling weights between neighbouring agents is designed for leader-following multi-agent systems under fixed and switching topologies. In traditional distributed static controllers, the coupling weights depend on the communication graph. However, coupling weights associated with the feedback gain matrix in our method are updated by state errors between neighbouring agents. We further present the stability analysis of leader-following multi-agent systems with stochastic disturbances under switching topology. Most traditional literature requires the graph to be connected all the time, while the communication graph is only assumed to be jointly connected in this paper. The design technique is based on Riccati inequalities and algebraic graph theory. Finally, simulations are given to show the validity of our method.
IL-15–High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15−/− Mice

In mice lacking IL-15, NK cell development is arrested at immature stages, providing an opportunity to investigate the earliest developing NK cells that would respond to IL-15. We show in this study that immature NK cells were present in the spleen as well as bone marrow (BM) and contained IL-15–high-responder cells. Thus, mature NK cells were generated more efficiently from IL-15−/− than from control donor cells in radiation BM chimeras, and the rate of IL-15–induced cell division in vitro was higher in NK cells in the spleen and BM from IL-15−/− mice than in those from wild-type mice. Phenotypically, NK cells developed in IL-15−/− mice up to the minor but discrete CD11b–CD27+DX5hiCD51dullCD127dullCD122hi stage, which contained the majority of Ly49G2+ and D+ NK cells both in the spleen and BM. Even among wild-type splenic NK cells, IL-15–induced proliferation was most prominent in CD11b–DX5hi cells. Notably, IL-15–mediated preferential expansion (but not conversion from Ly49– cells) of Ly49+ NK cells was observed in vitro only for NK cells in the spleen. These observations indicated the uneven distribution of NK cells of different developing stages with variable IL-15 responsiveness in these lymphoid organs. Immature NK cells in the spleen may contribute, as auxiliaries to those in BM, to the mature NK cell compartment through IL-15–driven extramarrow expansion under steady-state or inflammatory conditions.
Sensitization and Habituation of the Swimming Behavior in Ascidian Larvae to Light

Abstract Ascidian larvae of Ciona intestinalis change their photic behavior during the course of development. Newly hatched larvae show no response to a light stimulus at any intensity. At 4 hr after hatching, larvae were induced to start to swimming upon the cessation of illumination, and to stop swimming upon the onset of illumination. At a weaker light intensity (5.0×10−3 J/m2·s), the larvae showed similar responses to either a single stimulus or repeated stimuli of onset and cessation of light until 10 hr after hatching. At a stronger light intensity (3.2×10−1 J/m2·s), when the stimulus was repeated, they showed sensitization and habituation of the swimming response. At 3 hr after hatching the larvae failed to show any response to an initial stimulus at any intensity of light, but after several repeated stimuli (sensitization) they showed a swimming response at light intensities above 4.0×10−2 J/m2·s. At 5 hr and with intensity above 1.0×10−2 J/m2·s, the larvae showed photoresponses to the first stimulus, but after several repetitions the larvae failed to stop swimming upon the onset of light (habituation). A repeated series of stimuli at stronger intensities of light caused greater habituation; this habituation was retained for about 1 min. Since the larval central nervous system in Ciona is comprised of only about 100 neurons, learning behavior in ascidian larvae should provide insights for a minimal mechanism of memory in vertebrates.
Characterization of the Catalytic and Nucleotide Binding Properties of the α-Kinase Domain of Dictyostelium Myosin-II Heavy Chain Kinase A*

Background: Myosin II heavy chain kinase A (MHCK-A) is a member of the atypical α-kinase family. Results: The catalytic and nucleotide binding properties of the MHCK-A kinase domain are characterized. Conclusion: α-Kinases convert ATP to adenosine via formation of an aspartyl phosphate intermediate. Significance: The α-kinase active site has unique functions that may aid in the design of specific inhibitors. The α-kinases are a widely expressed family of serine/threonine protein kinases that exhibit no sequence identity with conventional eukaryotic protein kinases. In this report, we provide new information on the catalytic properties of the α-kinase domain of Dictyostelium myosin-II heavy chain kinase-A (termed A-CAT). Crystallization of A-CAT in the presence of MgATP yielded structures with AMP or adenosine in the catalytic cleft together with a phosphorylated Asp-766 residue. The results show that the β- and α-phosphoryl groups are transferred either directly or indirectly to the catalytically essential Asp-766. Biochemical assays confirmed that A-CAT hydrolyzed ATP, ADP, and AMP with kcat values of 1.9, 0.6, and 0.32 min−1, respectively, and showed that A-CAT can use ADP to phosphorylate peptides and proteins. Binding assays using fluorescent 2′/3′-O-(N-methylanthraniloyl) analogs of ATP and ADP yielded Kd values for ATP, ADP, AMP, and adenosine of 20 ± 3, 60 ± 20, 160 ± 60, and 45 ± 15 μm, respectively. Site-directed mutagenesis showed that Glu-713, Leu-716, and Lys-645, all of which interact with the adenine base, were critical for nucleotide binding. Mutation of the highly conserved Gln-758, which chelates a nucleotide-associated Mg2+ ion, eliminated catalytic activity, whereas loss of the highly conserved Lys-722 and Arg-592 decreased kcat values for kinase and ATPase activities by 3–6-fold. Mutation of Asp-663 impaired kinase activity to a much greater extent than ATPase, indicating a specific role in peptide substrate binding, whereas mutation of Gln-768 doubled ATPase activity, suggesting that it may act to exclude water from the active site.
High Prevalence of Peripheral Arterial Disease in Patients with Acute Ischaemic Stroke

Background: After acute ischaemic stroke (AIS) or transient ischaemic attack (TIA), the detection of peripheral arterial disease (PAD) as a marker of generalized atherosclerosis may improve the risk stratification and prevention of future atherothrombotic events. We aimed to determine the prevalence of PAD indicated by an ankle-brachial index (ABI) of ≤0.9 in a large cohort of patients with AIS/TIA. Methods: In this prospective, multicentre, Austrian, cross-sectional study (OECROSS), 759 patients with AIS or TIA were recruited for a systematic assessment of cardiovascular risk profiles and Doppler ultrasound at the ankle and brachial artery to calculate the ABI from systolic blood pressure readings. Results: 739 patients (97.4%) had a complete ABI assessment. The mean age was 69.5 (± 12.1) years, and 55.8% of the patients were men. 81.6% of the patients had AIS and 18.4% had TIA. Only 6.2% of the patients had a history of PAD, but an abnormal ABI of ≤0.9 was found in 44.9%. Patients with an ABI of ≤0.9 were more likely (p < 0.05) to be older and have a history of PAD, hypertension, diabetes and congestive heart failure. An ABI of ≤0.9 was significantly associated (p < 0.0005) with a presence of carotid stenosis of >50% and an Essen Stroke Risk Score of >2, indicating a risk of ≧4% per year of stroke recurrence. Discussion: A high proportion of patients with AIS/TIA have subclinical PAD, a cross-risk stroke physicians should be aware of. Large longitudinal studies are needed to elucidate whether the ABI can improve our estimation of the risk of future atherothrombotic events and help in optimizing secondary prevention.
Improving the roles of rural women in health and environmental issues

Abstract Safe water supply, sanitation facilities and safe environments are the priorities of the communities in the villages of Upper Egypt. However, personal hygienic behaviors need improvement for substantial promotion of family health. This cannot be met without the full participation of women in their various roles in their communities. Accordingly, 375 females belonging to rural villages of Egypt (VHVs) volunteered to have a role in health and sanitation aspects and disseminate hygienic messages to their communities. The objective of this study was to assess and upgrade the levels of awareness, attitude and practice of VHVs towards environmental sanitation, sanitary housing, personal hygiene, safe water, food safety, sanitary sewage and refuse disposals. Implementation of environmental health education courses resulted in significant improvement of VHVs' awareness, attitude and practice towards the majority of the environmental topics that were addressed. Similar extensive courses are recommended for the promotion of environmental sanitation in other communities.
Using Transistor Roles in Teaching CMOS Integrated Circuits

CMOS integrated circuit analysis and design is a fast paced field which deals with many advanced technologies and a difficult skill for many students in a comprehensive first course in Microelectronics. New methods and techniques to help novices learn are needed. In this paper the transistor role concept is used and common individual CMOS transistor roles are identified. Typical circuit and block symbols have been used and some new symbols are defined. Roles of transistors capture expert electronics engineers tacit knowledge in a way that can be explicitly taught to students; therefore, roles should be taught to students in order to distinguish different transistor configurations in an integrated circuit. The use of roles and role-based circuit analysis and design is also expected to facilitate the teaching of circuit analysis and synthesis. Key-Words: CMOS transistors, CMOS circuits, MOS amplifiers, transistor roles, Microelectronics, Macroelectronics, teaching, engineering education.
Seizures and EEG features in 74 patients with genetic‐dysmorphic syndromes

Epilepsy is one of the most common findings in chromosome aberrations. Types of seizures and severity may significantly vary both between different conditions and within the same aberration. Hitherto specific seizures and EEG patterns are identified for only few syndromes. We studied 74 patients with defined genetic‐dysmorphic syndromes with and without epilepsy in order to assess clinical and electroencephalographic features, to compare our observation with already described electro‐clinical phenotypes, and to identify putative electroencephalographic and/or seizure characteristics useful to address the diagnosis. In our population, 10 patients had chromosomal disorders, 19 microdeletion or microduplication syndromes, and 32 monogenic syndromes. In the remaining 13, syndrome diagnosis was assessed on clinical grounds. Our study confirmed the high incidence of epilepsy in genetic‐dysmorphic syndromes. Moreover, febrile seizures and neonatal seizures had a higher incidence compared to general population. In addition, more than one third of epileptic patients had drug‐resistant epilepsy. EEG study revealed poor background organization in 42 patients, an excess of diffuse rhythmic activities in beta, alpha or theta frequency bands in 34, and epileptiform patterns in 36. EEG was completely normal only in 20 patients. No specific electro‐clinical pattern was identified, except for inv‐dup15, Angelman, and Rett syndromes. Nevertheless some specific conditions are described in detail, because of notable differences from what previously reported. Regarding the diagnostic role of EEG, we found that—even without any epileptiform pattern—the generation of excessive rhythmic activities in different frequency bandwidths might support the diagnosis of a genetic syndrome. © 2014 Wiley Periodicals, Inc.
Genetically Defined Oligodendroglioma Is Characterized by Indistinct Tumor Borders at MRI

The authors wanted to determine whether imaging characteristics previously associated with oligodendroglial tumors were still applicable given the 2016 WHO classification that made IDH mutation and 1p/19q codeletion the defining features of oligodendroglioma. They found that 92% of genetically defined oligodendrogliomas had noncircumscribed borders, compared with 45% of non-1p/19q codeleted tumors with at least partial histologic oligodendroglial morphology. Ninety-nine percent of oligodendrogliomas were heterogeneous on T1- and/or T2-weighted imaging. BACKGROUND AND PURPOSE: In 2016, the World Health Organization revised the brain tumor classification, making IDH mutation and 1p/19q codeletion the defining features of oligodendroglioma. To determine whether imaging characteristics previously associated with oligodendroglial tumors are still applicable, we evaluated the MR imaging features of genetically defined oligodendrogliomas. MATERIALS AND METHODS: One hundred forty-eight adult patients with untreated World Health Organization grade II and III infiltrating gliomas with histologic oligodendroglial morphology, known 1p/19q status, and at least 1 preoperative MR imaging were retrospectively identified. The association of 1p/19q codeletion with tumor imaging characteristics and ADC values was evaluated. RESULTS: Ninety of 148 (61%) patients had 1p/19q codeleted tumors, corresponding to genetically defined oligodendroglioma, and 58/148 (39%) did not show 1p/19q codeletion, corresponding to astrocytic tumors. Eighty-three of 90 (92%) genetically defined oligodendrogliomas had noncircumscribed borders, compared with 26/58 (45%) non-1p/19q codeleted tumors with at least partial histologic oligodendroglial morphology (P < .0001). Eighty-nine of 90 (99%) oligodendrogliomas were heterogeneous on T1- and/or T2-weighted imaging. In patients with available ADC values, a lower mean ADC value predicted 1p/19q codeletion (P = .0005). CONCLUSIONS: Imaging characteristics of World Health Organization 2016 genetically defined oligodendrogliomas differ from the previously considered characteristics of morphologically defined oligodendrogliomas. We found that genetically defined oligodendrogliomas were commonly poorly circumscribed and were almost always heterogeneous in signal intensity.
Witches and Neighbours: The Social and Cultural Context of European Witchcraft

'Much nonsense has been written on this subject', wrote Keith Thomas in a famous and influential footnote to his own pioneering chapter on English witchcraft in Religion and the Decline of Magic (1971). In similar vein, Robin Briggs remarks near the st art of this magnificent new survey that 'common assumptions about the subject tend to have one very marked feature in common, which is that they are hopelessly wrong' (p. 9). The concept of witchcraft is notoriously slippery; scholarly research over the past quarter-century has barely changed the received ideas of most people. Some of what reputable and intelligent scholars have contributed to the subject has proved at best untypical of the wider witchcraft phenomenon, at worst seriously misleading. Robin Briggs has devoted many years to meticulous examination of a large body of trial records of witchcraft cases from the Duchy of Lorraine in the late sixteenth and seventeenth centuries. In this book he has brought the insights from that research to a synt hesis and survey of the social context of all early modern witchcraft cases in western Europe and New England. The resulting book will have a deeply corrosive effect on all sorts of traditional wisdom about the subject of witchcraft and society.
Prevalence and associations of dry eye syndrome in an older population: the Blue Mountains Eye Study

This report describes the prevalence of self‐reported dry eye syndrome and associations with systemic and ocular factors in an older Australian population. Participants of the Extension Blue Mountains Eye Study, aged 50 or older (mean age 60.8 years, n = 1174) completed a comprehensive eye examination and dry eye questionnaire. At least one dry eye symptom was reported by 57.5% of participants, with 16.6% reporting moderate to severe symptoms, more frequent in women (age‐adjusted odds ratio [OR] 1.5, 95% confidence interval [CI] 1.1−2.2). Three or more symptoms were reported by 15.3% of participants, also more frequent in women (age‐adjusted OR 1.7, CI 1.2−2.4). No age‐related trends or significant ocular associations were observed. After adjusting for age and sex, systemic factors significantly associated with dry eye syndrome included history of arthritis, asthma, gout, use of corticosteroids, antidepressants and hormone replacement therapy. In this older population, dry eye syndrome was common and has associations with female gender and systemic diseases.
A simple apparatus using inclinometer for monitoring working postures.

A new apparatus was developed for evaluating a load on the low back caused by working postures by measuring upper body inclination. This apparatus consists of an inclinometer and a portable unit. The inclinometer that uses a magnetic resistance sensor is attached to the upper body of the subject. The portable unit, controlled by a one-chip CPU, is enclosed in a cloth case and carried by the subject on his waist belt. The inclination is measured at a certain interval and recorded in the memory of the portable unit. All the recorded data are later transferred to a host computer and then analyzed. According to the theoretical analysis by using a simple mathematical model, upper body inclination changes according to the height of work places, and one cm difference in height causes more than one degree of upper body inclination. A model work of material handling was carried out to collect sample data. Two male subjects lifted ten boxes onto a platform from a stand in several heights. Both stooped and squat lifting methods were used as the lifting protocol. The mean and standard deviation (SD) of the upper body inclination during work decreased according to the lift distance only in stooped lifting. As a practical application, working postures during the task of changing diapers for handicapped people were analyzed with out apparatus. A female subject changed diapers eight times at different height of beds. The mean value of inclination decreased according to the height of the beds. (ABSTRACT TRUNCATED AT 250 WORDS)
GKS Based Graphics Programming in PROLOG

It is evident that every computer language needs a graphics extension for the same reason as it needs input and output functions. Graphics may be seen as a powerful extension of the input and output facilities. This is even more evident for interactive languages like PROLOG. PROLOG is a computer language widely accepted for the purpose of symbolic computation. It is gaining popularity because of its simplicity and the new descriptive way of programming. A PROLOG program is a description of a problem in the form of some assertions and rules about how the solution may be inferred from the facts. It also provides some powerful data processing mechanisms, mainly relational data base facilities, tree searching with backtracking, and pattern matching. All these advantages make PROLOG suitable for many applications such as relational data bases, architectural design, natural language understanding and other AI fields. Most of the applications mentioned above also need computer graphics. Thus, integration of graphics into PROLOG can be seen as a step towards providing a more intelligent environment for these applications. The design of the graphics extension described in this paper is based on the principles and concepts of the Graphical Kernel System (GKS) [8], GKS provides all capabilities required by most of the PROLOG applications that produce computer generated pictures. It provides a suitable methodological framework for the creation of computer graphics programs because of its consistency, completeness, and compactness.