Miracle-dz/UniFAR-FTUs huggingface dataset:
Citizen-Oriented Service Delivery and Innovation in the Passport Office in Indonesia

Public service delivery in Indonesia has undergone several adjustments since the fall of the authoritarian regime until the present time. This reform is marked by the utilisation of Information and communication technology in public services. Imigrasi is one of the public agencies that make the most of this technology development by launching a wide range of innovations in the field of public service. Consequently, according to the internal survey, public satisfaction level rises significantly. This outstanding achievement, however, is the subject of contestation before the principles of the New Public Service and the fundamental value of the Critical System Heuristics. As a support to these frameworks, a collaboration model from the Theory of Change will be elaborated. The project uses secondary data obtained from Imigrasi and assessed by the qualitative method. This work concludes by determining the appropriate ways to deliver the public services, especially in the Online Passport Service program and the following innovations as well as its implication towards public satisfaction level and trust. Some possible recommendations such as institutionalizing public participation and adopting a semi-autonomous system of local offices are believed to become a solutive decision towards world class public services.
Metabolic effects of the consumption of Areca catechu

Abstract Betel nut (Areca catechu) is chewed regularly by at least 10% of the world population, imported by immigrant users wherever they settle, and is the fourth most widely used addictive substance. It is thought, by users, to soothe the digestion and to be a stimulant and its use has a major role in social situations. Specific arecal alkaloids act as competitive inhibitors of GABA receptors and have widespread effects in the body, including actions on the brain, cardiovascular system, lungs, gut and pancreas. Nitrosated derivatives of arecal alkaloids, proven carcinogens inducing tumours throughout the upper gut and foregut derivatives in animals, are also associated with increased tumour risks in man. These nitrosated compounds are also diabetogenic in CD1 mice, producing a type 2 diabetes with obesity. Increased central obesity is found in association with betel usage in man as well as increases in circulating markers of inflammatory and cardiovascular damage. The effects of chronic betel usage in man are at least as diverse as those of smoking and the habit increases the risks of ill health.
Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells

To explore the significance of human papilloma virus type 52 (HPV52) infection and its integration in cells within cervical lesions, the expression levels of HPV52 were detected using polymerase chain reaction (PCR). The copy numbers of HPV52 E2, HPV52 E6 and the reference gene β-actin were determined by quantitative PCR to analyze the association between HPV52 integration and cervical lesions. HPV52 integration was analyzed by the amplification of papillomavirus oncogene transcripts. A total of 13 samples from 468 cases were positive for HPV52. Among the samples, 1 case with an E2/E6 ratio >1 was purely episomal, 3 cases with an E2/E6 ratio of 0 were purely integrated, and 9 cases with an E2/E6 ratio of between 0 and 1 were a mixture of integrated and episomal. With the progression of cervical disease, the prevalence of the episomal type decreased gradually, and the prevalence of the integrated (episomal and integrated) forms increased. The pure integration of HPV52 occurred in chromosomes 2, 5 and 8. These results indicate that HPV52 integration into the host genome may be a key factor in cervical lesions. Thus, patients at high risk for cervical lesions may potentially be identified by screening for HPV52 infection and integration.
Hyperforin in St . John ’ s Wort ’ s Central Effects : What is the Mechanism of Action ?

The constituent(s) accounting for the antidepressant/anxiolytic, nootropic and anti-Alzheimer’s properties of St John’s wort (SJW) extracts is uncertain but the phloroglucinol hyperforin has been described as the main cause. Although its activities in humans have not yet been thoroughly investigated, it has antidepressant-like and anxiolytic-like effects in animal models, while in vitro studies suggest an interaction with the neurotransmitter systems thought to be involved in depression. Some of its actions on the neurotransmitter systems have also been proposed to explain the nootropic effects of SJW extracts, for which another possible explanation followed the in vitro observation that hyperforin activates transient receptor potential canonical 6 channels, which are vital for the formation of dendritic spines, plasticity and memory. In vitro hyperforin also has direct effects on amyloid(A ) fibrils, providing a potential mechanism for the antagonism of A -induced neurotoxic effects and cognitive impairments. However, considering the low hyperforin brain uptake and concentrations reached in animals after pharmacologically effective doses of SJW extracts or authentic compound and its derivatives, its in vivo actions are unlikely to be due to direct interaction with acknowledged neurotransmitter transporters and receptors. Although it might interact with some central targets not yet evaluated in vitro, or even primarily act peripherally, thereby influencing central transmission, the central action may be due to one or more metabolites. Further neurochemical studies should therefore be extended to potential metabolite(s) which may have characteristic pharmacodynamic properties. Additional information is also needed on the brain uptake of hyperforin compared to its active metabolite(s). These data should enable us to identify the active principle (parent compound or its metabolite) and its target in the site of action, and undoubtedly help in extrapolating pharmacological findings across species. _____________________________________________________________________________________________________________
Communicating climate change: history, challenges, process and future directions

Since anthropogenic climate change first emerged on the public agenda in the mid‐to‐late 1980s, public communication of climate change and—more recently—the question of how to communicate it most effectively have witnessed a steep rise. This paper synthesizes what is known, presumed, and still unknown about how to effectively communicate this problem. An introductory historical overview of climate change communication is followed by a discussion of the challenges that communicators face in trying to convey the issue (invisibility of causes, distant impacts, lack of immediacy and direct experience of the impacts, lack of gratification for taking mitigative actions, disbelief in human's global influence, complexity and uncertainty, inadequate signals indicating the need for change, perceptual limits and self‐interest). The core of the paper focuses on key aspects of the communication process (purpose and scope of the communication, audience, framing, messages, messengers, modes and channels of communication, and assessing the outcomes and effectiveness of a communication). These elements are placed in relationship to several contextual factors that affect the communication process. The paper concludes with suggestions for future research on climate change communication. Copyright © 2010 John Wiley & Sons, Ltd.
Hybrid, Composite, and Complex Biomaterials

This presentation is concerned with chemical modifications of natural materials and their uses in composites and for surface modification. The ability to re-engineer naturally occurring polymers and to create biologically inspired polymers is redefining and diversifying the kinds of biocompatible materials that can be developed for reparative medicine and other medical applications. Ultimately, these materials must possess physicochemical, mechanical, and biological properties that facilitate the recapitulation of embryonic cell differentiation, growth, and proliferation in the adult organism. Moreover, surface modification and surface self-assembly methodologies can now improve the compatibility of implanted nonbiological medical devices. The discussion is focused primarily on the new materials themselves—what they are, what their purpose is, and what key research areas remain.
PREVALENCE OF MASTITIS PATHOGENS AND THEIR RESISTANCE AGAINST ANTIMICROBIAL AGENTS IN AWASSI SHEEP IN AL-BALQA PROVINCE OF JORDAN

The primary objective of this study was to establish data on mastitis in Awassi Sheep in Al-Balqa Province of Jordan. Milk samples were collected from 260 lactating ewes that selected randomly from eight flocks. California Mastitis Test (CMT) gave result with 220 milk samples; 122 samples (55.5%) showed positive CMT. Infection with some bacterial species was associated with positive CMT. About 26% of the ewes revealed clinical signs of mastitis. The highest percentage of bacterial count, which range from 3×102 to
Das Olberssche Paradoxon.

Am 7. Mai 1823 schickte der Bremer Arzt und Astronom Wilhelm Olbers einen Aufsatz Uber die Durchsichtigkeit des Weltraums an den Herausgeber des Astronomischen Jahrbuches fur 1826. Darin formulierte er eine Frage, die seither ein zentrales Problem der Kosmologie darstellt: Warum ist der Himmel nicht – tags wie nachts – an jedem Punkt so hell wie die Sonne, da doch in jeder Richtung des Raumes irgendwann ein Stern angetroffen werden sollte? Seine eigene Antwort, das Licht entfernter Sterne werde im Weltraum absorbiert, erwies sich als falsch. Uber die angemessene Losung des Problems herrschte lange Zeit eine eigentumliche Unklarheit. Erst die quantitativen Beobachtungen der modernen Kosmologie scheinen eine befriedigende Antwort zu erlauben.
Some Practical Considerations in B. Pertussis Vaccine Preparation.

IN the preparation of all bacterial vaccines, the essential problem is the same-to make available the specific antigens in a product which is safe for injection. But even the simplest preparation-a killed suspension of the bacteria concerned-involves innumerable technical difficulties. Before there is any basis for expecting satisfactory results, the requirements for an active vaccine must be determined and met. It seems entirely possible that failure at this point is responsible for the irregular, unsatisfactory results of various workers with B. pertussis vaccineresults which led to its omission from the list of New and Non-afficial Remedies of the American Medical Association in 1931.1 Recent reports, especially those of Madsen,2 Sauer,3 and our own,4 in which more encouraging results have been obtained, emphasize particularly the need for using antigenically active cultures. A basis for considering this of great importance is found in the bacteriological studies of several workers, more recently by Leslie and Gardner,5 Lawson,6 and Shibley and Hoelscher.7 In order to have clearly in mind the essential features of the preparations in use for these more re-
In silico Study of Target Proteins for Mycobacterium tuberculosis

The completion of the genome of pathogens and the human has provided data that can be utilized to design vaccines and drug targets. One of the recently adopted strategies for drug designing is based on comparative genomics approach, it gives a set of genes that are likely to be essential to the pathogen but absent in the host. By performing homology searches and structural modeling, we can determine which of these proteins can provide novel targets for designing functional inhibitor compounds active against bacteria. In this study, we used three proteins that are potential target, (NCBI Accession no.) NP_216679, NP_218309, NP_218312, for Mycobacterium tuberculosis. Physico-chemical characterization, prediction of secondary structure, disulfide bridges and functional characterization was done to interpret their properties. Three dimensional structure of these proteins were not available as yet at PDB. Therefore, homology models for these proteins were developed using Swiss model server, Modeller and ESyPred3D Web Server. The models were validated using PROCHECK. The study proved that NP_218312 was most stable structure and has good stereo chemical properties. Thus it is selected for further Docking study with antimicrobial peptide, aurein 1.2 and with available drug such as Pyrazinamide, Ethambutol and Isoniazid using HEX. Among these Aurein1.2 was found more effective than other drug, indicates this can be used for further drug designing for Mycobacterium tuberculosis.
Finding rules of attractive human poses using decision tree and generating novel attractive poses

In this paper, we propose a method to determine the rules for attractive poses and generate novel attractive poses based on the discovered rules. Given a set of attractive poses with a specific style and another set of unattractive poses, we can obtain the rules to separate those two sets of example poses by creating a decision tree based on the low-level pose features that are computed from the example poses. In this research, we implemented our approach for two kinds of attractive poses, Hero and JoJo standing poses, and successfully discovered the rules of these styles. We also developed a heuristic kinematics-based pose deformation method based on the discovered rules of attractive poses. The rules can be applied to any input pose with any specified scale. Using our system, a creator can interactively design novel poses.
Prebreakdown Phenomena in High-Viscosity Dielectric Liquids

The shadowgraphic image reflects only those regions of disturbance occurring in a dielectric liquid, which differ in refractive index from their surroundings. The time required for the onset of a prebreakdown disturbance after the application of a step voltage, and the rate of growth of the disturbance depend strongly on the viscosity (or the temperature) of the liquid. The refractive index is lower inside the disturbance region than outside. The variation of the external current is consistent with the temporal change of the disturbance. It is proposed that the formation of a disturbance region is due to the coulombic repulsion of local homocharges which in turn causes a decrease in local density and hence a decrease in refractive index. At highfields the anode injects holes to form positive ions and the cathode injects electrons, and theelectric conduction is filamentary. The electric breakdown in condensed materials (liquids and solids) involves double injection and the creation of low density regions to enable the charge-carrier multiplication processes to take place. Thus the breakdown strength is governed by the parameters which control the conditions for such prebreakdown phenomena to arise.
Tumour budding evaluated in biopsy specimens is a useful predictor of prognosis in patients with cN0 early stage oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) prognosis depends upon lymph node metastasis (LNM). We have reported recently that tumour budding is a good predictive factor for LNM in squamous cell carcinoma (SCC) of the tongue and floor of the mouth (FOM). Our aim was to evaluate whether tumour budding is a good prognostic factor in OSCC.
Purification and Characterization of an α-Actinin-binding PDZ-LIM Protein That Is Up-regulated during Muscle Differentiation*

α-Actinin is required for the organization and function of the contractile machinery of muscle. In order to understand more precisely the molecular mechanisms by which α-actinin might contribute to the formation and maintenance of the contractile apparatus within muscle cells, we performed a screen to identify novel α-actinin binding partners present in chicken smooth muscle cells. In this paper, we report the identification, purification, and characterization of a 36-kDa smooth muscle protein (p36) that interacts with α-actinin. Using a variety of in vitro binding assays, we demonstrate that the association between α-actinin and p36 is direct, specific, and saturable and exhibits a moderate affinity. Furthermore, native co-immunoprecipitation reveals that the two proteins are complexed in vivo. p36 is expressed in cardiac muscle and tissues enriched in smooth muscle. Interestingly, in skeletal muscle, a closely related protein of 40 kDa (p40) is detected. The expression of p36 and p40 is dramatically up-regulated during smooth and skeletal muscle differentiation, respectively, and p40 colocalizes with α-actinin at the Z-lines of differentiated myotubes. We have established the relationship between p36 and p40 by molecular cloning of cDNAs that encode both proteins and have determined that they are the products of a single gene. Both proteins display an identical N-terminal PDZ domain and an identical C-terminal LIM domain; an internal 63-amino acid sequence present in p36 is replaced by a unique 111-amino acid sequence in p40. Analysis of the sequences of p36 and p40 suggest that they are the avian forms of the actinin-associated LIM proteins (ALPs) recently described in rat (Xia, H., Winokur, S. T., Kuo, W.-L., Altherr, M. R., and Bredt, D. S. (1997) J. Cell Biol. 139, 507–515). The expression of the human ALP gene has been postulated to be affected by mutations that cause facioscapulohumeral muscular dystrophy; thus, the characterization of ALP function may ultimately provide insight into the mechanism of this disease.
Engineering the complete MANOS-type NVM stack for best in class retention performance

We demonstrate best in class performance for MANOS-type charge-trap flash non-volatile memory devices through improved program/erase (P/E), endurance and retention. Band-engineered (BE) tunnel-oxides (TO) and BE-SiNx charge-trap layers are employed to optimize program, erase, and endurance with trade-off in retention. However, for the 1st time we combine BE-TO, BE-SiNx, BE-blocking layer (BE-BL) and an oxygen-bearing high effective-work-function (EWF) electrode to dramatically improve retention while maintaining the combined benefits from the engineering of each individual stack component. Resulting device improvements include larger ΔVth P/E windows of ≫300%, enduring P/E cycles to at least 100K cycles while maintaining a window ≫4V, and retention approaching zero% charge loss over 24 hours at 150°C. The large, enduring windows with improved retention are favorable for multi-level cell application beyond the 30nm node.
A Comparison of Inward and Outward Foreign Direct Investment Determinants in Turkey

This study compares the outward foreign direct investments (FDI) in Turkey with inward FDI taking into account factors such as the location selection for outward FDI, the stimulus determinant of outward FDI and strategic entrance options for both inward and outward FDI. Based on surveys and interviews with 107 firms and 169 facilities five factors affecting location selection for inward FDI were found, 1) to gain presence in new markets, 2) enabling faster market entry, 3) maintaining an adequate quality control, 4) enabling faster payback on investment, and 5) economies of scale. However, the factors of outward FDI are as follows 1) the advantages of a “first mover”, 2) the growth rate of the Turkish economy, 3) the level of industrial competition, 4) market size, and 5) availability of low cost inputs. Differences are observed for acquisitions, greenfield operations, joint venture or wholly owned subsidiaries.
Prevalence of oral lesions in HIV infected adult population of Mangalore, Karnataka, India

The aim of this study was to find the prevalence of oral lesions in human immunodeficiency virus (HIV) positive patients and investigate if there was a relationship between oral manifestations and the level of immunosuppression. 125 patients infected with HIV in the age group of 20-40 years were examined for the presence of different oral lesions according to the EEC criterion. The CD4 count, as well as any therapy being instituted was recorded and correlated with the oral manifestations seen. Comparison of common oral lesions present to absent was done by chi square test using linear by linear association. The prevalence of oral lesions among the investigated HIV patients was found to be 71%, with periodontitis – 52% and erythematous candidiasis – 48% being the most prevalent oral lesions; as well, periodontitis and oral hairy leukoplakia were found to be significantly associated with the immunosuppression in the disease. Thus, oral lesions have been found to be associated with the early manifestation of HIV and a measure of disease severity.
Découverte des meilleures couvertures d'un concept en utilisant une terminologie

Les services web dits semantiques sont une proposition pour automatiser les tâches liees a la gestion des services web, paradigme recent pour l'integration d'applications inter-entreprises. Cette these s'interesse au probleme de leur decouverte dynamique, c'est-a-dire la possiblite de trouver automatiquement un ensemble de services web qui repondent a une requete, par raisonnement sur leur semantique. Dans le cadre des logiques de description, nous proposons de formaliser ce probleme comme une nouvelle instance de reecriture de concepts en utilisant une terminologie. Cette instance est appelee decouverte des meilleures couvertures et s'enonce ainsi : "etant donnes un concept Q (une requete) et une terminologie T de concepts (les services), le probleme consiste a rechercher les conjonctions de concepts de T (les ensembles de services) qui semantiquement se rapprochent le plus de Q". La notion de proximite semantique entre concepts est definie en s'appuyant sur l'operateur de difference semantique entre concepts des logiques de description. Elle consiste a minimiser les differences entre une requete Q et ses reecritures potentielles, maximisant ainsi l'information commune entre elles. Ce critere de reecriture est interessant car plus general et donc plus souple que les relations de subsomption ou d'equivalence utilisees habituellement. Pour les logiques de description ayant une propriete de subsomption structurelle, et pour ALN, nous montrons que le probleme est NP-Difficile et qu'il est fortement lie au probleme de la recherche des transversaux minimaux d'un hypergraphe. Nous proposons deux algorithmes appeles computeBCov et computeALNBCov. Un prototype implementant computeBCov a ete developpe au sein du projet europeen MKBEEM, permettant la validation de l'approche dans le domaine du tourisme
Homo symbolicus : the dawn of language, imagination and spirituality

1. Editors' introduction 2. Acknowledgements 3. Chapter 1. Pan symbolicus: A cultural primatologist's viewpoint (by McGrew, William C.) 4. Chapter 2. The evolution and the rise of human language: Carry the baby (by Savage-Rumbaugh, E. Sue) 5. Chapter 3. The origin of symbolically mediated behaviour: From antagonistic scenarios to a unified research strategy (by d'Errico, Francesco) 6. Chapter 4. Middle Stone Age engravings and their significance to the debate on the emergence of symbolic material culture (by Henshilwood, Christopher S.) 7. Chapter 5. Complex cognition required for compound adhesive manufacture in the Middle Stone Age implies symbolic capacity (by Wadley, Lyn) 8. Chapter 6. The emergence of language, art and symbolic thinking: A Neandertal test of competing hypotheses (by Zilhao, Joao) 9. Chapter 7. The human major transition in relation to symbolic behaviour, including language, imagination, and spirituality (by Sloan Wilson, David) 10. Chapter 8. The living as symbols, the dead as symbols: problematising the scale and pace of hominin symbolic evolution (by Pettitt, Paul) 11. Chapter 9. Biology and mechanisms related to the dawn of language (by Ellis, George F.R.) 12. Chapter 10. The other middle-range theories: Mapping behaviour and the evolution of the mind (by Dubreuil, Benoit) 13. Chapter 11. Metarepresentation, Homo religiosus, and Homo symbolicus (by Barrett, Justin L.) 14. Index