Miracle-dz/UniFAR-FTUs huggingface dataset:
Fuzzy sampled controller design for consensus of multiagent networks with varying connections

T-S fuzzy models are first presented to describe multiagent networks (MANs) with varying connections. The nodes of each T-S fuzzy model are rearranged so that the global fuzzy model is decomposed into independent and small-scale fuzzy models. It is shown that the consensus of the global fuzzy model is equivalent to that of its corresponding small-scale fuzzy models in which the sampled controller is applied. A sufficient condition is derived to ensure the consensus of the sampled controlling fuzzy models.
Quality improvement of H.264/AVC FRExt by incorporating perceptual models

This paper presents the quality improvement of the current video compression standard by incorporating Human Vision Models (HVS) into the standard coding structure. The advanced video coding (AVC) which is also called as H.264/MPEG-4 is the latest compression standard available for video compression. Fidelity Range Extension (FRExt) is the recent work done on the AVC which includes a number of enhanced capabilities relative to the base standards. FRExt aims at improving the quality of the reconstructed videos for some professional applications which require high resolution, such as video conferencing, video broadcast and studio quality videos. In this work a new codec incorporating HVS model has been proposed which gives improved visual quality compared to the MPEG 2, MPEG-4 AVC and FRExt. The proposed coder uses the Contrast Sensitivity Function (CSF) in the transform coding stage of the standard codec. To see the performance improvements of the proposed coder, AVC with FRExt features has been implemented first and the quality of the reconstructed video signals are evaluated using both subjective and objective measures such as MOS, PSNR, MSSIM, VIF and VSNR. The proposed coder shows a noticeable improvement in perceptual quality compared to the standard coders which promises scope for further improvements in the area of perceptual based video coders.
Genetic Determinations of Variable Responsiveness to Clopidogrel and Implications for Neurointerventional Procedures

Endovascular intervention is emerging as a substitute for open surgical procedures for the treatment of cerebrovascular disease. However, up to 9% of patients undergoing neurointerventional procedures develop thromboembolic complications. Strategies to reduce periprocedural thromboembolic events are dominated by the use of dual antiplatelet therapy (DAT) which has been validated based on studies of peripheral vascular and coronary intervention. Of note, DAT decreases adverse vascular outcomes by 75–80% in patients undergoing percutaneous coronary intervention (PCI). It follows that similar treatment effects would be observed in neurointerventional populations. However, a growing body of evidence demonstrates that a subgroup of patients respond suboptimally to DAT, and in particular to clopidogrel (termed clopidogrel hyporesponders). These patients may be at an increased risk of thromboembolic complications such as in-stent thrombosis following neurointerventional procedures. Previous studies report 5–30% suboptimal response to clopidogrel in the cardiovascular population, while a higher prevalence is seen in populations undergoing neurointerventional procedures, i.e. as much as 66%. Knowledge of the mechanism leading to clopidogrel hyporesponsiveness is accumulating. A number of genetic polymorphisms, in particular CYP 2C19*2, have been associated with clopidogrel hyporesponsiveness and clinical outcomes. In addition, there are significant differences in the prevalence of CYP 2C19*2 across racial groups. Approximately 50% of Asians and 25% of Caucasians harbor the CYP 2C19*2 allele. While no prospective randomized trials currently exist to demonstrate improved clinical outcomes with genotype-based treatment for carriers of the CYP 2C19*2 polymorphism, a number of studies show that an increased dose of clopidogrel improves platelet inhibition in hyporesponders. The aim of the review is to examine the current understanding of the genetic basis of clopidogrel hyporesponsiveness in patients undergoing neurointerventional procedures and to explore current efforts using genotype and phenotype testing as well as alternative strategies to overcome the clopidogrel hyporesponsiveness.
Dynamic Ultrasound Imaging Applications to Quantify Musculoskeletal Function

Advances in imaging methods have led to new capability to study muscle and tendon motion in vivo. Direct measurements of muscle and tendon kinematics using imaging may lead to improved understanding of musculoskeletal function. This review presents quantitative ultrasound methods for muscle dynamics that can be used to assess in vivo musculoskeletal function when integrated with other conventional biomechanical measurements.
T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus.

The target molecules of the T-cell response in type 1 diabetes, despite their pathogenic importance, remain largely uncharacterized, especially in humans. Interestingly, molecules such as insulin and glutamic acid decarboxylase (GAD) have been shown to be a target not only of autoantibodies, but also of autoreactive T-lymphocytes both in man and in the non-obese diabetic (NOD) mouse. In the present study we aimed to determine the existence of a specific T-cell response towards the insulinoma-associated protein 2 (IA-2) islet tyrosine phosphatase, a recently identified autoantigen which is the target of autoantibodies strongly associated with diabetes development. Human recombinant IA-2 produced in Escherichia coli, was tested for its reactivity with peripheral blood lymphocytes obtained from 16 newly diagnosed type 1 diabetic patients and from 25 normal controls, 15 of whom were HLA-DR-matched. A T-cell proliferation assay was performed in triplicate employing freshly isolated cells in the absence or in the presence of the antigen to be tested (at two different concentrations: 2 microg/ml and 10 microg/ml). A specific T-cell proliferation (defined as a stimulation index (S.I.) >/=3) was observed against IA-2 used at a concentration of 10 microg/ml (but not of 2 microg/ml) in 8/16 diabetic patients, in 1/15 HLA-DR-matched control subjects (P<0.01 by Fisher exact test) and in 0/10 of the remaining normal individuals. A statistically significant difference (P<0.003 by Mann-Whitney U test) was also observed in S.I. values between patients (3.1+/-1.4) and HLA-DR-matched controls (1.7+/-0.54) employing IA-2 at a concentration of 10 microg/ml. However, when IA-2 was used at a concentration of 2 microg/ml, the difference in S. I. between patients (1.65+/-0.8) and controls (1.0+/-0.3) did not reach statistical significance. In conclusion, these data show the presence of a specific, dose-dependent T-lymphocyte response against the IA-2 islet tyrosine phosphatase at the onset of type 1 diabetes. Consequently, this molecule appears to be a target not only at the B-lymphocyte but also at the T-lymphocyte level, reinforcing the potential pathogenic role of this autoantigen in the islet destructive process.
New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?

AIM To evaluate and compare the expression of thioredoxin reductase 1 (TrxR1) in primary and secondary glioblastoma samples. MATERIAL AND METHODS Surgically resected human glioblastoma samples from 40 patients who underwent surgery at our institution were extracted from their histopathological specimens and divided into three groups. Ten histopathologically regular cerebral tissue samples, acquired from the non-neoplastic portion of the specimens, were assigned as the control group. Twenty specimens that included tumoral tissue from each type of glioblastoma (WHO grade IV, primary and secondary) were assigned as the primary and secondary glioblastoma groups. TrxR1 expression was analyzed by using both quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry. Isocitrate dehydrogenase 1 (IDH1) mutation was analyzed by immunohistochemistry. Ki-67 proliferative index and apoptosis were also analyzed by immunohistochemistry. The differences between the groups were statistically compared and the correlation between these parameters was analyzed. RESULTS The expressions of TrxR1 and Ki-67 values were significantly higher in primary glioblastoma. IDH1 mutation was significantly higher in secondary glioblastoma. TrxR1 expression was found to be highly correlated with the Ki-67 index. The apoptotic index was similar between primary and secondary glioblastoma. CONCLUSION This study showed a high TrxR1 expression in primary glioblastoma which could indicate a role of the Trx system in promoting the malignant progression by some complex processes.
Addition of gentamicin to endoscopic retrograde cholangiopancreatography (ERCP) contrast medium towards reducing the frequency of septic complications of ERCP

OBJECTIVE: Bacteremia and sepsis are serious complications of endoscopic retrograde cholangiopancreatography (ERCP) and occur in between 0.5 and 3% of cases. Patients with obstructed bile ducts are at highest risk of developing septic complications. The purpose of this investigation was to determine whether the addition of gentamicin to the ERCP contrast medium prevents or reduces the growth of Pseudomonas aeruginosa in vitro.
Cones of skin occur where hypertrophic scar occurs

Hypertrophic scarring is devastating for the patient, however the pathophysiology and treatment remain unknown after decades of research. The process follows deep dermal injury, occurs only on certain body parts, does not occur in the early fetus or in animals, and is a localized event. This suggests that an anatomic structure in human, deep dermis may be involved. The dermis is a matrix perforated by cones containing many structures including skin appendages and fat domes. We hypothesized that studying the cones might reveal a structure related to scarring. We examined tangential wounds from various body parts on human cadavers along with skin histology from various human body parts, the early fetus, partial thickness burns, hypertrophic scars, and two other species—rats and rabbits. We found that the cones may in fact be the structure. They exist where hypertrophic scar occurs—cheek, neck, chest, abdomen, back, buttock, arm, forearm, dorsal hand, thigh, leg, dorsal foot, helix and ear lobe. They do not exist where hypertrophic scar does not occur—scalp, forehead, concha, eyelid, palm, early fetus, and in rat, or rabbit. It also became apparent that the cones have been omitted from most considerations of skin histology. We suggest that the cones need to be studied in relation to hypertrophic scarring and restored to skin diagrams.
Adherence to practice guidelines for atypical glandular cells on cervical cytology

Atypical glandular cells (AGC) on cervical cytology are high–risk, requiring an extensive evaluation. Compliance with practice guidelines for AGC, however, has been low. Some AGC cytology reports contain cytopathologist recommendations for evaluation. This study determines whether evaluation rates for AGC have improved over time, and whether cytopathologists' recommendations correlate with the types of evaluation women receive.
Coordinate Control and Selective Expression of the Full Complement of Replication-dependent Histone H4 Genes in Normal and Cancer Cells*

The replication of eukaryotic genomes necessitates the coordination of histone biosynthesis with DNA replication at the onset of S phase. The multiple histone H4 genes encode identical proteins, but their regulatory sequences differ. The contributions of these individual genes to histone H4 mRNA expression have not been described. We have determined, by real-time quantitative PCR and RNase protection, that the human histone H4 genes are not equally expressed and that a subset contributes disproportionately to the total pool of H4 mRNA. Differences in histone H4 gene expression can be attributed to observed unequal activities of the H4 gene promoters, which exhibit variations in gene regulatory elements. The overall expression pattern of the histone H4 gene complement is similar in normal and cancer cells. However, H4 genes that are moderately expressed in normal cells are sporadically silenced in tumor cells with compensation of expression by other H4 gene copies. Chromatin immunoprecipitation analyses and in vitro DNA binding assays indicated that 11 of the 15 histone H4 genes interact with the cell cycle regulatory histone nuclear factor P, which forms a complex with the cyclin E/CDK2-responsive co-regulator p220NPAT. These 11 H4 genes account for 95% of the histone H4 mRNA pool. We conclude that the cyclin E/CDK2/p220NPAT/histone nuclear factor P signaling pathway is the principal regulator of histone H4 biosynthesis.
Aggregation procedure of Gaussian Mixture Models for additive features

In this work we provide details on a new and effective approach able to generate Gaussian Mixture Models (GMMs) for the classification of aggregated time series. More specifically, our procedure can be applied to time series that are aggregated together by adding their features. The procedure takes advantage of the additive property of the Gaussians that complies with the additive property of the features. Our goal is to classify aggregated time series, i.e. we aim to identify the classes of the single time series contributing to the total. The standard approach consists in training the models using the combination of several time series coming from different classes. However, this has the drawback of being a very slow operation given the amount of data. The proposed approach, called GMMs aggregation procedure, addresses this problem. It consists of three steps: (i) modeling the independent classes, (ii) generation of the models for the class combinations and (iii) simplification of the generated models. We show the effectiveness of our approach by using time series in the context of electrical appliance consumption, where the time series are aggregated by adding the active and reactive power. Finally, we compare the proposed approach with the standard procedure.
[Trauma in the elderly caused by traffic accident: integrative review].

OBJECTIVE To describe the scientific knowledge produced about trauma in the elderly caused by traffic accidents in healthcare area studies. METHODS :Integrative review of studies from 2003 to 2013 searched in LILACS, SciELO, PubMed and CINHAL databases. We used combination of the descriptors injuries, wounds and accidents, in English, Portuguese and Spanish languages. RESULTS 32 studies were selected. In the thematic analysis, three categories emerged: epidemiological data from traffic accidents involving elderly; traffic accidents with elderly pedestrians; and trauma care in the elderly. We observed increased incidence of trauma in most countries and pedestrians represented a large part of the victims. Among these, the elderly are the most vulnerable group. CONCLUSION Studies showed that trauma care in the elderly need protocols and professionals with training in gerontology specialized in trauma care services.
Longer Sleep Duration and Midday Napping Are Associated with a Higher Risk of CHD Incidence in Middle-Aged and Older Chinese: the Dongfeng-Tongji Cohort Study.

STUDY OBJECTIVES To analyze the independent and combined relations of sleep duration and midday napping with coronary heart diseases (CHD) incidence along with the underlying changes of cardiovascular disease (CVD) risk factors among Chinese adults. METHODS We included 19,370 individuals aged 62.8 years at baseline from September 2008 to June 2010, and they were followed until October 2013. Cox proportional hazards models and general linear models were used for multivariate longitudinal analyses. RESULTS Compared with sleeping 7- < 8 h/night, the hazard ratio (HR) of CHD incidence was 1.33 (95% CI = 1.10 to 1.62) for sleeping ≥ 10 h/night. The association was particularly evident among individuals who were normal weight and without diabetes. Similarly, the HR of incident CHD was 1.25 (95% CI = 1.05 to 1.49) for midday napping > 90 min compared with 1-30 min. When sleep duration and midday napping were combined, individuals having sleep duration ≥ 10 h and midday napping > 90 min were at a greater risk of CHD than those with sleeping 7- < 8 h and napping 1-30 min: the HR was 1.67 (95% CI = 1.04 to 2.66; P for trend = 0.017). In addition, longer sleep duration ≥ 10 h was significantly associated with increases in triglycerides and waist circumference, and a reduction in HDL-cholesterol; while longer midday napping > 90 min was related to increased waist circumference. CONCLUSIONS Both longer sleep duration and midday napping were independently and jointly associated with a higher risk of CHD incidence, and altered lipid profile and waist circumference may partially explain the relationships.
Requirement for maintenance and gain of crude protein for two genotypes of growing quails

The objective of this study was to estimate the requirements for maintenance and gain of crude protein in Japanese and European quails aged 16-36 days. To determine the maintenance requirements, one experiment was conducted in a completely randomized design with four decreasing feeding levels (100, 75, 50 and 25%) and four replicates per treatment. The method of comparative slaughter was used, through a feeding assay. A total of 352 quails from each strain were housed by supply level in 16 pens measuring 1.0 × 1.5 m, totaling 22 birds per cage under ambient temperature conditions (26±0.5 oC). To estimate the requirement gains, one experiment was conducted with five groups of quails fed ad libitum and housed under controlled temperature of 18 oC. All poultry were slaughtered at 16, 21, 26, 31 and 36 days of testing for determination of body composition in protein throughout growth. The requirement for maintenance of the Japanese quail differs from that obtained with the European quail. The protein was retained at the proportion of 32% for European quails and 25% for the Japanese quails. This difference in retention promoted estimate of 0.65 g/g gain in European quails and 0.84 g/g gain in Japanese quails. Quails should be fed diets formulated considering the requirement for protein of each genotype.
Towards Intelligent Ontology Alignment Systems for Question Answering: Challenges and Roadblocks

This paper introduces the main challenges and future research directions for the Ontology Alignment prob- lem. To date a good number of ontology alignment solutions have been proposed. These solutions utilise a wide variety of techniques from machine learning to uncertain reasoning. However, none of the approaches have proved to be an inte- grated solution, which can be used by different communities. Since 2004, the Ontology Alignment Initiative (OAEI) has established an annual evaluation for systems that could be tested using the same datasets. This, of course, has helped to improve the work on ontology alignment, as the ontology community now has a set of common datasets to make comparisons on the performance of different algorithms for ontology alignment. In this paper we discuss the main challenges and roadblocks that need to be addressed in order to built successful mapping frameworks. Finally this paper presents DSSim and our results on the ontology evaluation 2008.
A enhancement technology about system security based on dynamic information flow tracking

Based on information security technology of speculation implementation hardware, we design and implement the SHIFT(Speculative Hardware based Information Flow Tracking) system to enhance software security in cloud computing platform. SHIFT system uses that processor support delay exceptions, design and implement efficient dynamic information flow tracking technology. The system can detect low-level attacks such as buffer overflow attack, while effective defense other high-level semantic attacks based on SQL injection attacks (SQL Injection) and cross-directory traversal attacks (Directory Traversal). The system have the best performance in all practical system based on dynamic information flow tracking technology. In practical testing based on Apache WebServer, SHIFT system have only 1% performance loss.
Factorisation of Probability Trees and its Application to Inference in Bayesian Networks

Bayesian networks can be seen as a factorisation of a joint probability distribution over a set of variables, based on the conditional independence relations amongst the variables. In this paper we show how it is possible to achieve a finer factorisation decomposing the origninal factors in which some conditions hold. The new ideas can be applied to algorithms able to deal wih factorised probabilistic potentials, as Lazy Propagation, LazyPenniless as well as Monte Carlo methods based on Importance Sampling.
SRPDB: Signal Recognition Particle Database

The Signal Recognition Particle Database (SRPDB) at http://psyche.uthct. edu/dbs/SRPDB/SRPDB.html and http://bio.lundberg. gu.se/dbs/SRPDB/SRPDB.html assists in the better understanding of the structure and function of the signal recognition particle (SRP), a ribonucleoprotein complex that recognizes signal sequences as they emerge from the ribosome. SRPDB provides alphabetically and phylogenetically ordered lists of SRP RNA and SRP protein sequences. The SRP RNA alignment emphasizes base pairs supported by comparative sequence analysis to derive accurate SRP RNA secondary structures for each species. This release includes a total of 181 SRP RNA sequences, 7 protein SRP9, 11 SRP14, 31 SRP19, 113 SRP54 (Ffh), 9 SRP68 and 12 SRP72 sequences. There are 44 new sequences of the SRP receptor alpha subunit and its FtsY homolog (a total of 99 entries). Additional data are provided for polypeptides with established or potential roles in SRP-mediated protein targeting, such as the beta subunit of SRP receptor, Flhf, Hbsu and cpSRP43. Also available are motifs for the identification of new SRP RNA sequences, 2D representations, three-dimensional models in PDB format, and links to the high-resolution structures of several SRP components. New to this version of SRPDB is the introduction of a relational database system and a SRP RNA prediction server (SRP-Scan) which allows the identification of SRP RNAs within genome sequences and also generates secondary structure diagrams.
Influence of the counterion on the synthesis of ZnO mesocrystals under solvothermal conditions.

Polymers and coordinating solvents have been shown to serve as templating agents to assist the precipitation of ZnO nanoparticles and address their morphology. In this work we show for the first time that a difference in the coordination strength between the polymer (poly-N-vinylpyrrolidone (PVP)) and the two Zn(II) precursor salts (nitrate and acetate) is able to promote or suppress the formation of mesocrystalline structures and even more importantly to tune their three-dimensional organization. On the basis of FTIR and (13)C NMR spectroscopic studies, we propose that not only the polymer (PVP) but also the solvent (DMF) play a key role as directing agents.