Miracle-dz/UniFAR-FTUs huggingface dataset:
A Rare Cause of Hyperamylasemia: Macroamylasemia

Artmis serum amilaz aktivitesi akut pankreatit ve tukruk bezi enflamasyonunda siklikla gorulmekle birlikte nadir olarak, tedavi gerektirmeyen benign bir fenomen olan makroamilazemide de gorulmektedir. Hiperamilazemi karin agrisi ile basvuran hastalarda zaman zaman tanisal karisikliga yol acabilen bir laboratuvar bulgusudur. Serum amilaz duzeyi yuksekligi ve karin agrisi, makroamilazemik hastalarin yanlis akut pankreatit tanisi almalarina yol acabilir. Karin agrisi ve hiperamilazemisi olan ancak pankreatiti destekleyen goruntuleme bulgusu olmayan hastalarda makroamilazemi de akilda bulundurulmalidir. Burada karin agrisi ve kalici amilaz yuksekligi ile basvuran makroamilazemili bir olguyu sunmaktayiz. Hastanin sikayeti olmadan, uc ay sonra poliklinik takibinde lipaz degeri normal iken amilaz yuksekligi (450 U/L) devam etmekteydi
The name of the Italian water vole Arvicola cf. amphibius (Linnaeus, 1758)

This paper deals with the correct name of the distinct lineage of Arvicola cf. amphibius found south of the Alps. It confirms that Arvicola italicus Savi, 1838, type locality near Pisa, is the first available name for the Italic water vole. However, the traditional allocation of Italic water voles to two distinct taxa, italicus in central-northern Italy and musignani de Selys Longchamps, 1839 in central-southern Italy, cannot be accepted until the identity of Pisa and Maremma populations studied by Paolo Savi is not established.
The comparison of effectiveness of two variants of preventive anesthesia/analgesia in cancer surgery

Despite modern drugs and technologies in medicine, the questions of adequate analgesia in the postoperative period remain quite relevant. The effectiveness of preventive analgesia in the perioperative period remains a contentious issue. The study included 53 oncosurgical patients. Gr.1 received dexketoprofen in combination with paracetamol for perioperative analgesia before the operation, Gr.2 the same medication was given before closing the operating wound. Anesthesia in both groups included an inhaled (Sevoran) and an extended epidural. The study showed that the pain intensity on ANI monitoring and the total dose of fentanyl was less in Gr.1, compared to Gr.2. Cortisol plasma level and the level of glycemia in the perioperative period were less in patients in Gr.1 than in Gr.2. Pain intensity after surgery during first postoperative day was lower in Gr.1, then in Gr.2. The administration of multimodal analgesia with paracetamol and dexketoprofen prior to the surgical interventions provides for the best quality of perioperative analgesia in oncological surgical interventions.
Synthesis and Evaluation of Water Insoluble but Swellable Bioadhesive Polymer for Ocular Drug Delivery

Introduction: Our main purpose of present study was to find out the effect of different crosslinking agents along with its concentration during polymer synthesis and to find the most suitable polymer for ocular drug delivery with optimum bioadhesive strength and less irritation potential. It was expected that the synthesized polymer will remain adhered to the conjunctival mucin layer thus preventing loss of drug by precorneal factors. Materials and methods: Acrylic acid procured from Loba chemicals was polymerized with Divinyl glycol from Merck specialities Private limited, Divinylbenzene and 2, 5-dimethyl-1, 5-hexadiene from Alfa Aesar to form water insoluble swellable polymer. Different parameters like density, polymer hydration, Differential Scanning Calorimetry, Infra-Red spectroscopy, X ray diffraction and mucoadhesive strength were determined. Polymer hydration was studied with respect to time, pH and ionic strength. HET-CAM test and Draize skin irritation test was performed to evaluate the degree of irritation caused by these polymers. Results and Discussion: It was found that as more hydrophobic groups were introduced in the polymer structure, hydration potential was reduced. The effect of concentration of crosslinking agent on bioadhesive strength was significant. With increase in density of crosslinking agent, the bioadhesive strength decreased. Polymers were found to be non-irritant to slight irritant in nature.
Effect of Alcohol on Sexual Dysfunctions and Hormonal Profiles in Male Wistar Rats

Alcohol can affect the hypothalamo-pituitary gonadal axis leading to impotence and sterility by various mechanisms of action. Until recently, alcohol induced liver disease was considered to be primarily responsible for sexual dysfunction in alcoholic men. Ethanol impairs testosterone production by being a direct testicular toxin and by interfering with pituitary luteinizing hormone secretion. In chronic alcohol fed rats, testicular atrophy is associated with reduced plasma testosterone levels by reducing the number of LH binding testicular receptors and also by interfering with the enzymes involved in testosterone biosynthesis. Healthy Male Wister rats were selected for this study, exposure of alcohol with 6% alcohol in feeding bottles orally for 90 days, compared to normal – control rats, the parameters were studied are Mounting Index (MI), Total Sexual Behaviour (TSB), Sperm count, Serum Testosterone by RIA methods, histopathology of target organs and Pituitary were observed under special Histochemical staining: AB-BR-OFG method. In this present study Total sexual behavior (TSB) in normal rats showed: 210.0 ± 0.56 compared to alcohol exposed rats: 260.0 ± 0.96, Sperm count in normal rats: 61.33 ± 0.47 and alcohol exposed rats: 55.33 ± 0.30, Serum World Journal of Pharmaceutical Research SJIF Impact Factor 5.990 Volume 4, Issue 7, 455-468. Research Article ISSN 2277– 7105
HEARING LOSS AND SATİSFACTION OF HEARING AID IMPACT ON QUALITY OF LIFE IN GERİATRİC POPULATION

ÖZET Amaç: Presbikuzi geriatrik populasyonda yaygın bir bozukluktur. Birçok çalışma, rehabilite edilmemiş işitme kaybının azalmış yaşam kalitesine, sosyal kısıtlılıklara,depresyona, kognitif fonksiyonların kaybına katkıda bulunabileceğini göstermiştir. Bu çalışmanın amacı, işitme kaybı olan bireyleri işitme cihazı kulanımı öncesinde ve sonrasında, Dünya Sağlık Örgütü kısa yaşam kalitesi ölçeği (WHOQOL-Bref-Tr) , geriatrik depresyon ölçeği (GDS) ve yaşlılar için işitme engellilik ölçeği( İEÖ-Y) envanterleri ile yaşam kalitelerini değerlendirmektir. Yöntem ve Gereçler: Çalışmaya işitme kaybı olan 20 geriatrik katılımcı dahil edildi. Hastalar WHOQOL-Bref-Tr, GDS, İEÖ-Y envanterlerindeki soruları cevaplandırdılar,işitme cihazı kullanımından 3 ay sonra yine bu sorulara cevap verdiler ve IOI-HA anketini doldurdular, tüm skorlar cihaz kullanımı öncesi sonuçlarla karşılaştırıldı. Bulgular: Genel yaşam kalitesinde, İEÖ-Y toplam sosyal ve emosyonel skorlarda iyileşme görüldü. GDS skorlarında istatiksel olarak bir değişim izlenmedi,işitme cihazından faydalanma,rezidüel aktivite sınırlaması, memnuniyet, rezidüel katılım kısıtlılığı, başkaları üzerindeki etki ve yaşam kalitesine etkiyi içeren IOI-HA envanterinde ortalama skor 4,12 ± 0,78'di. Sonuç: İşitme cihazı kullanımı yaşlıların yaşam kalitesi ile pozitif ilişkidedir.
Évaluation de la mise en place d'un protocole de soins « Urgence Thrombose » au CHU Timone

Objectif : decrire l’utilisation d’algorithmes diagnostiques, pronostiques et therapeutiques de la maladie thromboembolique veineuse (MTEV), directement issus des recommandations, au service des urgences Timone et comparer deux groupes : le groupe 2015 « sans protocole de soins » et le groupe 2017 « avec protocole de soins ». Methode : etude retrospective de 141 patients admis aux urgences du CHU Timone a Marseille pour MTEV de janvier a juin 2015 pour le groupe 2015 et de janvier a juin 2017 pour le groupe 2017. Les caracteristiques cliniques des patients, de l’episode de MTEV et de la prise en charge hospitaliere etaient colligees. Resultats : 79 patients ont ete inclus dans le groupe 2015 et 62 patients dans le groupe 2017. Dans 24% des cas un score de probabilite clinique a ete calcule dans le groupe 2017 (0 dans le groupe 2015 p<0,001). Il n’y a pas de difference significative sur l’application des algorithmes diagnostiques (30,3% groupe 2015 vs 27,4% groupe 2017). Dans aucun des groupes etudies, le score de gravite sPESI n’a ete note dans le dossier. Tous les patients ayant presente une embolie pulmonaire ont ete hospitalise quel que soit le score sPESI. 36% des patients admis pour TVP ont ete hospitalises dans le groupe 2015 tandis que pour le groupe 2017 la prise en charge a ete uniquement ambulatoire. 52,5% des patients ont ete traite par AOD dans le groupe 2017 contre 32,5% dans le groupe 2015 (p=0,018). Dans 18% des cas un AOD a ete prescrit par les urgentistes dans le groupe 2017 contre 2,5% dans le groupe 2015 (p=0,002). La duree moyenne d’hospitalisation etait de 7,4 jours dans le groupe 2017 et de 9,4 jours dans le groupe 2015 (p=0,03). Conclusion : nous montrons une amelioration du calcul du score de probabilite clinique, une augmentation de la prise en charge ambulatoire des TVP, une augmentation de la prescription des AOD et une reduction de la duree d’hospitalisation. L’integration d’un calcul obligatoire et informatique des scores de probabilite clinique et pronostique permettrait d’optimiser ce parcours, ainsi qu’une meilleure diffusion de la consultation post-urgences crees pour les patients traites en ambulatoire.
Molecular biology of orthobunyaviruses

The Orthobunyavirus genus comprises over 170 named viruses, including the prototype of the Bunyaviridae family, Bunyamwera virus, as well medically significant viruses such as La Crosse and Oropouche viruses, and pathogens of veterinary importance like Akabane and Cache Valley viruses. In this chapter we review the molecular characteristics of orthobunyavirus genomes and encoded proteins, and details of the orthobunyavirus replication cycle. We describe how the development of reverse genetics has paved the way to understand interactions of orthobunyaviruses with the host cell, and in particular the evasion of the host innate immune response. Finally we review the differences in virus replication in vertebrate and invertebrate cells.
Physical Activity and Sexual Health in Men

The primary aim of the study was to examine the correlation between the physical activity level and three factors of sexual health in men (sexual desire, sexual function and sexual satisfaction). The sample consisted of 509 male students aged 18 to 30 (M=19.70; SD=1.38). The results suggest a significantly better erectile function and sexual satisfaction in sufficiently physically active compared to insufficiently physically active men, while no significance was found in sexual desire and premature ejaculation. The findings indicate that the level of physical activity is positively related to sexual health factors, regardless of whether the dominant aerobic or anaerobic type of physical activity is practiced. Men with higher number of exercise hours on weekly basis have higher sexual desire and better erectile function. Men who are more satisfied with their own body image, have better erectile function. Although previous studies point to positive correlation between physical activity and sexual health in older age groups, this study points to better sexual health of physically active men already in the student age.
Viral nephropathies in renal transplantation with a special emphasis on adenovirus infection

Allograft nephropathy from a viral infection is an evolving challenge in renal transplant (RT) recipients. It is commonly the consequence of potent immunosuppression aimed at reducing rejection and improving graft survival. Untreated viral infection may lead to graft dysfunction or loss. Although decreased immunosuppression is the principle treatment in majority of these infections, graft failure is commonly encountered in advanced cases.
On evolutionary conservation of mitotic checkpoint signaling

The mitotic checkpoint is a control mechanism that ensures proper microtubule-kinetochore attachment and correct chromosome segregation during mitosis. A defective checkpoint signal can lead to chromosome missegregation and aneuploidy, which can lead to cancer. In this report I will summarize the different mitotic checkpoint proteins and their function in inhibiting metaphase to anaphase transition when defective kinetochore-microtubule attachment occurs. As research has been done in many different model organisms I will mainly focus on the evolutionary conservation of the mitotic checkpoint and its proteins. I conclude that the mitotic checkpoint complex is a well conserved mechanism from yeast to human. Although it seems that every organisms has some specific small differences and that higher eukaryotes need extra mechanisms to regulate the checkpoint, the core idea remains the same. Comparing the results obtained in different organisms also gives new insides in what features of the mitotic checkpoint are not yet well established and need more research.
Optimizing perioperative physical therapy care in major elective surgery to improve surgical outcome in high-risk patients: the Better in, Better out™ concept.

Frail elderly patients undergoing major surgery experience a decrease of physical capacity due to their hospital stay and surgery. This affects the risk of postoperative complications and their performance of activities, independence and participation.The Better in, Better out™ (BiBo™) strategy was developed to reduce these risks through the optimization and professionalization of perioperative hospital care in a physically activating context
The effect of levocetirizine and montelukast on clinical symptoms, serum level and skin expression of COX-1 and COX-2 enzymes in patients suffering from chronic autoimmune urticaria – a pilot study

Introduction Chronic autoimmune urticaria (CAU) lasts over 6 weeks and is characterized by circulating IgE autoantibodies or IgG against IgE or IgE receptor. Aim To assess the clinical, laboratory and histological effects of 4-week levocetirizine and montelukast therapy in patients suffering from CAU. Material and methods Of 296 tested patients with chronic urticaria 40 had a positive ASST test. Only 17 (16 female/1 male; medium age: 44 years) fulfilled all study inclusion/exclusion criteria. The study was designed as an open, randomized trial with two arms: levocetirizine or montelukast treatment for 4 weeks following a 2-week wash-out period. All participants completed urticaria activity score (UAS) and visual analogue scale (VAS) questionnaires before and after both therapies. Blood samples and skin bioptats were obtained before and after treatment to evaluate COX-1 and COX-2 serum concentrations and skin expression. Results Clinical response to therapy measured with the UAS and VAS was better in the levocetirizine group. Both drugs caused a significant decrease in COX-1 and COX-2 serum level. COX-1 and COX-2 expression in epidermal and dermal inflammatory infiltration did not change significantly in either study group, but a significant decrease of COX-1 expression was observed when the groups were combined for analysis, and the decrease in COX-2 expression in the epidermis was of borderline significance. Conclusions The effectiveness of levocetirizine and montelukast in treating CAU may be partly related to the reduction of COX-1 and COX-2 serum level and tissue expression, but further studies on a larger group of patients are needed to support this observation.
Intervenções com profissionais de saúde da atenção primária sobre aconselhamento à atividade física: revisão sistemática

O objetivo do estudo foi descrever as intervenções realizadas com profissionais de saúde na atenção primária com o foco no aumento do aconselhamento à prática de atividade física. Foi realizada uma revisão sistemática da literatura nas bases de dados PubMed, Lilacs, Scopus, SciELO e Bireme, com as seguintes palavras-chave: primary health care; intervention; physical activity; exercise; health promotion; counseling; advice; health professionals; health workers. Foram incluídos oito estudos, sendo a maioria de metodologia quantitativa e publicado na última década. As intervenções foram realizadas em três países, com amostras heterogêneas de profissionais de saúde e usuários da atenção primária. Quanto ao efeito da intervenção sobre o aumento do aconselhamento à atividade física, metade dos estudos mostrou ser positivo, enquanto a outra metade não apresentou diferença. Os resultados apresentam que ainda são poucas as intervenções com profissionais de saúde na atenção primária relacionadas ao aconselhamento à atividade física e metade delas mostraram efeito positivo. São necessárias novas intervenções abrangendo diferentes profissionais da saúde em um número maior de unidades de saúde.
A Serum Protein Biomarker Panel Improves Outcome Prediction in Human Traumatic Brain Injury

Abstract Brain-enriched protein biomarkers of tissue fate are being introduced clinically to aid in traumatic brain injury (TBI) management. The aim of this study was to determine how concentrations of six different protein biomarkers, measured in samples collected during the first weeks after TBI, relate to injury severity and outcome. We included neurocritical care TBI patients that were prospectively enrolled from 2007 to 2013, all having one to three blood samples drawn during the first 2 weeks. The biomarkers analyzed were S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1), tau, and neurofilament-light (NF-L). Glasgow Outcome Score (GOS) was assessed at 12 months. In total, 172 patients were included. All serum markers were associated with injury severity as classified on computed tomography scans at admission. Almost all biomarkers outperformed other known outcome predictors with higher levels the first 5 days, correlating with unfavorable outcomes, and UCH-L1 (0.260, pseduo-R2) displaying the best discrimination in univariate analyses. After adjusting for acknowledged TBI outcome predictors, GFAP and NF-L added most independent information to predict favorable/unfavorable GOS, improving the model from 0.38 to 0.51 pseudo-R2. A correlation matrix indicated substantial covariance, with the strongest correlation between UCH-L1, GFAP, and tau (r = 0.827–0.880). Additionally, the principal component analysis exhibited clustering of UCH-L1 and tau, as well as GFAP, S100B, and NSE, which was separate from NF-L. In summary, a panel of several different protein biomarkers, all associated with injury severity, with different cellular origin and temporal trajectories, improve outcome prediction models.
Transarterial chemoembolisation with lipiodol for unresectable hepatocellular carcinoma

Poster: "ECR 2018 / C-2587 / Transarterial chemoembolisation with lipiodol for unresectable hepatocellular carcinoma" by: "P. Desai K N, I. Subbanna, V. Bhargavi, U. P. Pankar; Bangalore/IN"
Effect of intensity and duration of quantitative feed restriction on broiler caecum microbiota

This study evaluated the effects of quantitative feed restriction with different intensity and duration on broiler intestinal microbial flora. Using a completely randomized design, Ross 308 male broiler chicks (115; 3 replications/ treatment; 10 chicks/replication) were assigned to 5 experimental treatments. These included quantitative feed limitations in 50% (T2,T3) and 25% (T4,T5) lower than the recommended by the Ross 308 broiler catalogue in 2 periods of 7 (T2, T4) and 14 days (T3, T5), with one control treatment (T1; feed intake as ad lib.). All chicks were fed ad lib. before and after the limitation period, until slaughter (day 42). The results showed that quantitative feed restriction had significant effects on microbiota of ceca in broilers except for lactic acid bacteria. A feed restriction of 25% during 7 days (T4) resulted in the highest mean value for coliforms and Escherichia coli; in contrast, a feed restriction of 25% during 14 days (T5) resulted in the highest mean value for lactobacilli and enterobacteria. A feed restriction of 50% during 7 days did not affect microbial count when compared with the control group. The number of total bacteria was higher in T4 although the difference had not been statistically significant from T2 and T3. Major alterations occurred for E. coli and coliforms in T4, lactobacilli and enterobacteriaceae in T5 and enterecoccus in both T3 and T4. It is concluded that a feed restriction of 25% during 7 days (T4) gave rise to the growth of other species than those analyzed in this study whereas a feed restriction of 25% during 14 days increased lactobacilli and enterobacteriaceae.
SAT0156 Association between cumulative methotrexate dose, non-invasive scoring system and hepatic fibrosis detected by fibroscan in rheumatoid arthritis patients receiving methrotrexate.

Background: Methotrexate (MTX) is recommended by recent ACR and EULAR guideline as a first-line drug for RA. Liver fibrosis, which occurs as long-term side effect is one of the most concerns. Objectives: To find the association between clinical parameters, cumulative MTX dosage, liver fibrosis scoring systems and the presence of liver fibrosis assessed by transient elastography (TE; Fibroscan®). Methods: Rheumatoid arthritis, prescribed MTX, patients had been evaluated of liver fibrosis with TE. Two subgroups of patients were compared: non-fibrosis and fibrosis (TE >7 kPa). Univariate and multivariate logistic regression analysis were performed to identify factors associated with liver fibrosis. Results: One hundred and eight patients were recruited. Twenty-nine patients (26.8%) were classified by transient elastography as liver fibrosis cases. The multivariate analysis demonstrated only the statistically significant of the association in BMI (OR=1.217; 95%CI 1.048–1.414; P=0.010); fatty liver (OR=2.318; 95%CI 0.584–9.189; P=0.232); ALT (OR=1.044; 95%CI=1.003–1.087; P=0.036) and cumulative MTX dosage (OR 1.001; 95%CI 1.000–1.001; P=0.001). Conclusions: Liver fibrosis measured with Fibroscan was associated with cumulative MTX. RA patients with metabolic syndrome including high BMI, IFG, fatty liver had higher risk of MTX-induced hepatic fibrosis. RA patients with high cumulative MTX dose, especially patients with concurrent metabolic syndrome should be cautiously monitored for liver fibrosis. Disclosure of Interest: None declared
The Use of Human Dendritic Cell Subsets in Cancer Vaccines

Dendritic cells (DC) have been used as therapeutic tools in cancer vaccines for more than a decade. The majority of clinical trials conducted in this field of immunotherapy have employed DC generated ex vivo from monocytes (moDC), as these DC can be easily propagated into large numbers. However, the clinical efficacy of moDC-based vaccines has remained unsatisfactory, as the laborious culturing protocols lead to exhaustion of their immunostimulatory capacity. Novel therapeutic strategies seek to capitalize on the distinct biological functions of naturally occurring DC subsets, i.e. myeloid DC (mDC) and plasmacytoid DC (pDC). Present in the skin, blood and secondary lymphoid organs, these subsets are capable of eliciting potent anti-tumour responses. Each subset has a specified effect on the immune system, and especially skin mDC and pDC are of interest for their capacity to induce tumour regression. Although natural DC subsets do not require extensive culturing periods, they are low in frequency and complicated isolation techniques are required to obtain them in sufficient number and purity. However, in vivo targeting techniques and identification of vaccine adjuvants that provide potent activation stimuli are promising developments. Combination therapies with conventional anti-cancer drugs can be considered to overcome the tolerogenic immune environment and stimulate efficient anti-tumour immunity.