Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of coupled microinductors for power-supplyon-chip applications

Coupled microinductors fabricated on silicon offer improved voltage regulator performance and reduced power loss compared to equivalent uncoupled microinductors. An analysis of coupled microinductors variables is presented which illustrates the optimum number of phases in terms of efficiency and impact on other circuit components. Models for eddy core loss which accounts for phase angle variation are included and are used to investigate a number of coupled inductor configurations designed for operation in a 9 W multiphase DC-DC converter. Their performance is analysed and models are validated.
Sequential expression of murine homeo box genes during F9 EC cell differentiation.

We have isolated and characterized a previously unknown member of the murine homeo box family. The new locus, m31, is located on chromosome 15 and is more homologous to sequences contained in the Drosophila homeotic gene, Antp, than to any other known murine homeo box. We show that this gene encodes a 2.7 kb mRNA which is expressed during mouse embryogenesis and during differentiation of F9 teratocarcinoma cells into parietal endoderm cells. The transcript appears late in this differentiation process and is most abundant at a time when the F9 cells begin to express tissue‐specific markers and the expression of another murine homeo box gene, m6, has decreased.
Evaluation of Etest MBL for Detection of blaIMP-1 and blaVIM-2 Allele-Positive Clinical Isolates of Pseudomonas spp. and Acinetobacter spp

ABSTRACT The Etest MBL (AB BIODISK, Solna, Sweden) correctly differentiated all 57 isolates of Acinetobacter spp. and Pseudomonas aeruginosa with the blaIMP-1 allele and 135 of 137 (98.5%) Acinetobacter spp. and Pseudomonas spp. isolates with the blaVIM-2 allele. The Etest MBL was reliable for detecting the IMP-1- and VIM-2-producing Pseudomonas and Acinetobacter isolates.
Human monoclonal antibody inhibits Porphyromonas gingivalis hemagglutinin activity.

BACKGROUND Porphyromonas gingivalis has been implicated as an important pathogen in the development of chronic periodontitis, and its colonization of subgingival sites is critical in the pathogenic process. One potential virulence factor, hemagglutinin, may mediate bacteria attachment onto and penetration into host cells, as well as agglutinate and lyse erythrocytes to intake heme, an absolute requirement for growth. We previously cloned the gene encoding the 130 kDa hemagglutinin domain (130k HMGD) and identified its functional domain. The construction of a human monoclonal antibody that is capable of inhibiting the hemagglutinating ability is significant and important toward the development of passive immunotherapy. METHODS Human lymphocytes isolated from a donor, who had high antibody titer against the recombinant 130k HMGD (r130k HMGD), were immortalized by Epstein-Barr virus, and specific antibody-producing B cells were established by panning using the r130k HMGD. RESULTS The constructed HuMAb-HMGD1, IgG subclass, recognized the r130k HMGD as well as the 43 and 49 kDa major bands in P. gingivalis cells and vesicles. The HuMAb-HMGD1 significantly inhibited hemagglutinating activity of P. gingivalis vesicles in a dose-dependent manner. Furthermore, the HuMAb-HMGD1 recognized the synthetic peptide, EGSNEFAPVQNLTGSSVG, which contains the functional domain of 130k HMGD. CONCLUSION The newly constructed HuMAb-HMGD1 may prove to be useful for the development of passive immunization against periodontal diseases caused by P. gingivalis infection, pending the results of fertility study in disease mode.
Signaling pathways for cardiac hypertrophy and failure.

Heart failure is a leading cause of mortality in the United States. As a result of advances in genetic technology, a molecular basis of heart failure is emerging.1,2 This review highlights the ways in which these insights are leading to new therapeutic targets in patients with acquired forms of heart failure. Morphologic Classification of Cardiac Hypertrophy Myocardial hypertrophy is an early milestone during the clinical course of heart failure and an important risk factor for subsequent cardiac morbidity and mortality. In response to a variety of mechanical, hemodynamic, hormonal, and pathologic stimuli, the heart adapts to increased demands for .
Clinical Assessment of Rapidly Acting Agents in Rheumatoid Arthritis

The discovery by Hench, Kendall, Slocumb, and Polley (1949) of the therapeutic effects of cortisone in rheumatoid arthritis has stimulated the trial of many other steroids whose action might possibly be similar. Unfortunately the lack of cortisone in this country, with which such substances could be directly compared, has led to considerable difficulty in the interpretation of results. That many therapeutic trials have been carried out using unsatisfactory experimental methods has been strikingly illustrated by the recent controversy over the efficacy or otherwise of deoxycortone and ascorbic acid in rheumatoid arthritis. Some workers (Lewin and Wassdn, 1949; LeVay and Loxton, 1950; and others) claim categorically that very remarkable results were being obtained; others (Kellgren, 1949; Spies et al., 1949; Kersley et al., 1950; Fletcher et al., 1950; Copeman et al., 1950) declare equally definitely that their results were negative. Similar claims, though less dramatic, are being made for other steroids lacking an oxygen atom at the 11 position-for example, " pregnenolone" (Davison et al., 1950; Freeman et al., 1950)-but, again, others have failed to confirm these results (Henderson et al., 1950, who quote much unpublished work). Clinical improvement has been the basis of most claims of therapeutic success. It is necessary, however, to support these claims by the demonstration that such improvement is real, and that it is due in fact to the particular substance administered. Quite apart from normal fluctuations occurring as part of the natural history of rheumatoid arthritis, the psychological effect of giving a new treatment may be considerable, especially as the dramatic effects of cortisone have become widely known. That such effects may be pronounced has been emphasized by Wolf (1950) in a paper entitled "The Effects of Suggestion and Conditioning on the Action of Chemical Agents-the Pharmacology of Placebos. " Our aim has been to adopt methods of assessment of clinical improvement, with special reference to rheumatoid arthritis, which will show conclusively whether or not an apparently beneficial effect is due to the trial substance. A detailed description of the methods used is given. These have been applied to deoxycortone and ascorbic acid therapy as described by Lewin and Wassen (1949), since their claims were both dramatic and precise: improvement was said to occur within minutes of
Effects of the angiotensin II antagonist losartan in hypertensive patients with renal disease.

OBJECTIVE To study the effects of the angiotensin II antagonist losartan in hypertensive patients with renal disease. DESIGN A single-blind longitudinal study was performed, lasting 4 months. Patients were treated once a day with placebo, 50 mg losartan, 100 mg losartan and placebo, each for 1 month, in sequence. Measurements were taken at the end of each treatment period. PATIENTS The study subjects comprised 13 patients with biopsy-proven renal disease, a diastolic blood pressure of > 90 mmHg, creatinine clearance of > 60 ml/min and stable proteinuria of > 2.0 g/day. RESULTS Mean arterial pressure, measured 4 h after the dose, fell from 113.8 +/- 2.1 mmHg (placebo) to 99.2 +/- 2.4 mmHg (50-mg dose) and 96.5 +/- 2.4 mmHg (100-mg dose). This blood pressure lowering effect was sustained for 24 h 116.3 +/- 2.3 mmHg (placebo) versus 105.5 +/- 1.8 mmHg (50-mg dose) and 103.3 +/- 1.9 mmHg (100-mg dose)]. The glomerular filtration rate remained stable, while the effective renal plasma flow increased by 12.5 +/- 2.9% (100-mg dose). The systemic and renal hemodynamic effects were similar at the 50- and 100-mg doses. Urinary excretion of total protein, albumin and immunoglobulin G decreased dose-dependently by a maximum of +/- 50% (100-mg dose). With the high dose, serum uric acid fell from 0.43 +/- 0.02 mmol/l to 0.39 +/- 0.02 mmol/l, and potassium increased from 4.2 +/- 0.1 to 4.6 +/- 0.1 mmol/l. CONCLUSIONS The angiotensin II antagonist losartan lowers blood pressure and displays a favorable renal profile in hypertensive patients with renal disease.
UAV Search : Maximising Target Acquisition

This paper is an academic experience report describing analysis of optimal control techniques for simulated quad-rotor unmanned aerial vehicles (UAVs) performing search and rescue missions. Analysis of the controller and guidance laws governing the UAV are described in detail culminating in a closed form expression describing the probability of detection over a certain field.
Borrelia burgdorferi-Associated Primary Cutaneous Marginal-Zone B-Cell Lymphoma: A Case Report

An association between Borrelia burgdorferi with primary cutaneous B-cell lymphoma (PCBCL) has long been suspected but just recently, thanks to a polymerase chain reaction technique, it had been possible to demonstrate B. burgdorferi-specific DNA in skin lesions of patients with different PCBCL subtypes. Locating cases of PCBCL that are related to B. burgdorferi infection could be really important for therapeutic implications; in fact, there are several reports of PCBCL responding to antibiotic therapy against B. burgdorferi. We report a case of B. burgdorferi-associated primary cutaneous marginal-zone B-cell lymphoma that, after specific antimicrobial therapy, did not show any clinical regression. We can conclude that additional studies are necessary in order to establish the use of antimicrobial therapy in B. burgdorferi-associated PCBCL.
Taking a Chance on College: Is the Tennessee Education Lottery Scholarship Program a Winner?

Most policies seeking to improve high school achievement historically either provided incentives for educators or punished students. Since 1991, however, over a dozen states, comprising approximately a quarter of the nation's high school seniors, have implemented broad-based merit scholarship programs that reward students for their high school achievement with college financial aid. This paper analyzes one of these initiatives, the Tennessee Education Lottery Scholarships, using individual-level data from the ACT exams. The program did not achieve one of its stated goals, inducing more students to prefer to stay in Tennessee for college, but it did induce large increases in performance on the ACT. Policies that reward students for performance do affect behavior and may be an effective way to improve high school achievement.
Design of TAS-MRAM prototype for NV embedded memory applications

In this paper, we present a new design of TAS-MRAM, which is dedicated for the embedded applications. The Thermally Assisted Switching (TAS) approach allows the low power memory programming and Pre-Charge Sense Amplifiers (PCSA) enable the reliable, high speed and low power sensing. By using a TAS-MTJ spice model integrating the precise experimental parameters and CMOS 130nm technology, simulations have been done to demonstrate the expected performances; a 128Kb prototype has been developed to validate experimentally the new design by means of standard cell and automatic macro generation techniques.
Superconvergence of monotone difference schemes for piecewise smooth solutions of convex conservation laws

In this paper we show that the monotone difference methods with smooth numerical fluxes possess superconvergence property when applied to strictly convex conservation laws with piecewise smooth solutions. More precisely, it is shown that not only the approximation solution converges to the entropy solution, its central difference also converges to the derivative of the entropy solution away from the shocks.
Hantavirus N Protein Exhibits Genus-Specific Recognition of the Viral RNA Panhandle

ABSTRACT A key genomic characteristic that helps define Hantavirus as a genus of the family Bunyaviridae is the presence of distinctive terminal complementary nucleotides that promote the folding of the viral genomic segments into “panhandle” hairpin structures. The hantavirus nucleocapsid protein (N protein), which is encoded by the smallest of the three negative-sense genomic RNA segments, undergoes in vivo and in vitro trimerization. Trimeric hantavirus N protein specifically recognizes the panhandle structure formed by complementary base sequence of 5′ and 3′ ends of viral genomic RNA. N protein trimers from the Andes, Puumala, Prospect Hill, Seoul, and Sin Nombre viruses recognize their individual homologous panhandles as well as other hantavirus panhandles with high affinity. In contrast, these hantavirus N proteins bind with markedly reduced affinity to the panhandles from the genera Bunyavirus, Tospovirus, and Phlebovirus or Nairovirus. Interactions between most hantavirus N and heterologous hantavirus viral RNA panhandles are mediated by the nine terminal conserved nucleotides of the panhandle, whereas Sin Nombre virus N requires the first 23 nucleotides for high-affinity binding. Trimeric hantavirus N complexes undergo a prominent conformational change while interacting with panhandles from members of the genus Hantavirus but not while interacting with panhandles from viruses of other genera of the family Bunyaviridae. These data indicate that high-affinity interactions between trimeric N and hantavirus panhandles are conserved within the genus Hantavirus.
Aerobic and anaerobic metabolism in oxygen minimum layer fishes: the role of alcohol dehydrogenase

SUMMARY Zones of minimum oxygen form at intermediate depth in all the world’s oceans as a result of global circulation patterns that keep the water at oceanic mid-depths out of contact with the atmosphere for hundreds of years. In areas where primary production is very high, the microbial oxidation of sinking organic matter results in very low oxygen concentrations at mid-depths. Such is the case with the Arabian Sea, with O2 concentrations reaching zero at 200 m and remaining very low (<0.1 ml O2 l–1) for hundreds of meters below this depth, and in the California borderland, where oxygen levels reach 0.2 ml O2 l–1 at 700 m with severely hypoxic (<1.0 ml O2 l–1) waters at depths 300 m above and below that. Despite the very low oxygen, mesopelagic fishes (primarily lanternfishes: Mytophidae) inhabiting the Arabian Sea and California borderland perform a daily vertical migration into the low-oxygen layer, spending daylight hours in the oxygen minimum zone and migrating upward into normoxic waters at night. To find out how fishes were able to survive their daily sojourns into the minimum zone, we tested the activity of four enzymes, one (lactate dehydrogenase, LDH) that served as a proxy for anaerobic glycolysis with a conventional lactate endpoint, a second (citrate synthase, CS) that is indicative of aerobic metabolism, a third (malate dehydrogenase) that functions in the Krebs’ cycle and as a bridge linking mitochondrion and cytosol, and a fourth (alcohol dehydrogenase, ADH) that catalyzes the final reaction in a pathway where pyruvate is reduced to ethanol. Ethanol is a metabolic product easily excreted by fish, preventing lactate accumulation. The ADH pathway is rarely very active in vertebrate muscle; activity has previously been seen only in goldfish and other cyprinids capable of prolonged anaerobiosis. Activity of the enzyme suite in Arabian Sea and California fishes was compared with that of ecological analogs in the same family and with the same lifestyle but living in systems with much higher oxygen concentrations: the Gulf of Mexico and the Southern Ocean. ADH activities in the Arabian Sea fishes were similar to those of goldfish, far higher than those of confamilials from the less severe minimum in the Gulf of Mexico, suggesting that the Arabian Sea fishes are capable of exploiting the novel ethanol endpoint to become competent anaerobes. In turn, the fishes of California exhibited a higher ADH activity than their Antarctic relatives. It was concluded that ADH activity is more widespread in fishes than previously believed and that it may play a role in allowing vertically migrating fishes to exploit the safe haven afforded by severe oxygen minima.
Exploring the Subsalt

Oilfield Review From the earliest days of exploration, prospectors associated salt with oil and gas—but not always for the right reasons. In the 1920s, so many successful wells were drilled around salt domes that logging methods were tuned to identify the high-salinity water in formations overlying pay zones.1 By 1923, gravity and seismic methods became successful in spotting salt domes, and the industry was on its way to understanding the structural role played by salt. Today, interpreters can view and tour salt structures with the help of powerful graphics workstations (next page, top). Salt is one of the most effective agents in nature for trapping oil and gas: as a ductile material, it can move and deform surrounding sediments, creating traps; salt is also impermeable to hydrocarbons and acts as a
Down-Regulation of Tomato β-Galactosidase 4 Results in Decreased Fruit Softening1

Transcript abundance of the gene encoding β-galactosidase II, a β-galactosidase/exo-galactanase (EC 3.2.1.23) present during tomato (Lycopersicon esculentum) fruit ripening, was suppressed by expression of an antisense tomato β-galactosidase 4 (TBG4) cDNA driven by the cauliflower mosaic virus 35S promoter. RNA gel-blot analysis was used to evaluate TBG4 mRNA levels in transgenic fruit. All of the antisense lines had attenuated TBG4 mRNA levels in turning stage fruit; however, TBG4 mRNA suppression was unstable, and mRNA levels varied in red-ripe fruit among the lines. Suppression of TBG4 mRNA levels in antisense fruit was correlated with a reduction in extractable exo-galactanase activity against a lupin galactan. All of the antisense lines had reduced free galactose levels at mature green stage 4, but levels comparable with controls during ripening. Total cell wall galactosyl contents in the antisense fruit were not significantly different from control fruit. Whole-fruit firmness was measured using a texture analyzer and the means of the peak force measurements for four of six antisense lines were significantly higher than control fruit. One antisense line had red-ripe fruit that were 40% firmer than controls. Fruit from this antisense line also had the lowest TBG4 mRNA and exo-galactanase levels and the highest wall galactosyl content during the early stages of ripening, implicating an involvement of this gene product in cell wall modification leading to fruit softening.
Adaline for fault detection in Electrical High Voltage transmission line

The application of neural networks to power systems has been extensively reported. Neural networks based protection techniques have been proposed by a number of authors. However, almost all the studies have so far employed the back-propagation neural network structure with supervised learning. This paper presents an on line method for fault identification in Electrical High Voltage (EHV) transmission line. This approach utilizes linear adaptive neuron, which is called Adaline. The Adaline neural network is generally used for prediction and identification problems and is rarely used for power system protection. Using current signals, the Adaline process has a strong tracking capability and is fast due to its simple construction, which makes it more suitable for the implementation. Our Adaline approach is compared with a multilayer perceptron in order to see the influence of the fault resistance over the fault time detection.
Reply: Mutations in the CHCHD10 gene are a common cause of familial amyotrophic lateral sclerosis.

Sir, A recent study by Bannwarth and colleagues has shown that variation in the CHCHD10 gene is a cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (Bannwarth et al. , 2014). The study identified a c.176C > T (p.Ser59Leu, NM_213720.1) missense mutation in a multi-generational kindred. In the present study, we performed genome sequencing of four affected individuals from a large ALS family (USALS#5). This identified a G to T transversion at position c.44 (chr22:24,109,778, hg19) that segregated with disease within this pedigree and leads to a p.R15L amino acid change in exon two of the CHCHD10 mitochondrial protein. Previous attempts to identify the causative mutation in this …
An Analytical Expression for Performance of Optimum Combining with Multiple Correlated CCIs and Two Antennas

We derive an analytical expression for the average output signal-to-interference-plus-noise ratio (SINR) of optimum combining (OC) for spatially correlated signals from two antennas in the presence of correlated multiple co-channel interferers (CCIs) and Rayleigh fading. First, the moment generating function (MGF) of the output SINR is derived. Then we obtain the probability density function (PDF) by taking the Fourier transform of the characteristic function (c.f.) corresponding to the MGF. Using the derived expression, the average output SINR performance of OC is evaluated as the number of the correlated multiple CCIs increases.
On the trust system in China's B2C electronic-commerce

With the rapid development of world's information service industry, e-commerce has become the central focus for many international companies and transnational enterprises across the world. China's e-commerce has already turned into one of major forms of expanding business activities in today's rapid development. Using e-commerce enterprises can not only reduce transaction cost and raise transactional efficiency in short term, but also can produce strategic profit in the long term. But trust is the key factor to success in online transaction and e-commerce. Business-to-Customer (B2C) is one of the mainstream businesses. From multi-angle, the paper analyzes the trust problems in B2C e-commerce. It first analyzes the causes of lack of trust in e-commerce environment and the characteristics of trust in B2C e-commerce. Then it discusses the trust system in B2C e-commerce from multi-faceted perspective of users, service providers, Internet technology and social environment. Finally, it proposes some ways to set up the trust in B2C e-commerce.