Miracle-dz/UniFAR-FTUs huggingface dataset:
Still Not Solved: The Persistent Problem of IT Strategic Planning

The disaffection of information technology managers with IT strategy development and planning goes back a long way. The research that identifies this dissatisfaction is examined briefly. The technology strategy and planning problem is shown to be multi-faceted, with several possible causes that may be operating simultaneously in a particular company. A major ingredient of the problem is the alignment/linkage of IT planning and plans, and the business plans. For IT planners to achieve the desired linkage requires that the planners possess a deep understanding of their company’s business planning. Similarly, business managers must possess solid knowledge of their company’s IT planning. Using Kiviat Diagrams, business planning approaches are shown to be bewildering in their variety. This variety indicates that IT planning managers must find it difficult to decipher business planning in general and the nature of their company’s business planning in particular. Nine approaches to plan alignment and linkage are explored, each with respect to its possible value for linking IT planning and plans to business planning and plans. The development of a Theory of Plan Linkages is proposed. Several sources of the problem are suggested, and several IT management approaches to IT planning are explored briefly. It is unlikely that any single set of IT planning activities can deal satisfactorily with the problem for most companies. Efforts are proposed for developing best practices for IT planning. Steps are proposed for use by IT planners to improve their companies’ IT strategy development processes. Areas that merit further academic research are explored.
Activation of canonical Wnt/β‐catenin signaling stimulates proliferation in neuromasts in the zebrafish posterior lateral line

Background: The posterior lateral line in zebrafish develops from a migrating primordium that deposits clusters of cells that differentiate into neuromasts at regular intervals along the trunk. The deposition of these neuromasts is known to be coordinated by Wnt and FGF signals that control the proliferation, migration, and organization of the primordium. However, little is known about the control of proliferation in the neuromasts following their deposition. Results: We show that pharmacological activation of the Wnt/β‐catenin signaling pathway with 1‐azakenpaullone upregulates proliferation in neuromasts post‐deposition. This results in increased size of the neuromasts and overproduction of sensory hair cells. We also show that activation of Wnt signaling returns already quiescent supporting cells to a proliferative state in mature neuromasts. Additionally, activation of Wnt signaling increases the number of supporting cells that return to the cell cycle in response to hair cell damage and the number of regenerated hair cells. Finally, we show that inhibition of Wnt signaling by overexpression of dkk1b suppresses proliferation during both differentiation and regeneration. Conclusions: These data suggest that Wnt/β‐catenin signaling is both necessary and sufficient for the control of proliferation of lateral line progenitors during development, ongoing growth of the neuromasts, and hair cell regeneration. Developmental Dynamics 242:832–846, 2013. © 2013 Wiley Periodicals, Inc.
Stress and Depression: A Pre and Post Cochlear Implant Comparative Study

Parents of children with hearing impairment tend to exhibit “depression” a known stress related response. Mothers of hearing impaired child are more prone than fathers to experience depression [1,2]. In addition, these mothers are found to be less successful in cultivating language and psychological development of their children. The study aimed to measure pre and post cochlear implantation (CI) levels of maternal stress and depression. Total of 5 mothers were supplied with Parental Stress Scale (PSS) and Centre for Epidemiologic studies Depression Scale (CESD) adapted in Kannada Language pre and post CI of their children. Wilcoxon Signed Ranks test was applied to the obtained data.No significant difference in mean levels of stress and depression pre and post CI (p<0.05) was observed. The results provide preliminary evidence that mothers of children with hearing impairment experience higher levels of stress and depression.
Methods and Techniques of Security Testing: A Survey

: Security Testing helps in protecting the software against unanticipated actions. The target of security testing is to provide assurance regarding that the software is safe and secure. Security testing is very helpful in identifying loop holes and security risk in the software. Our Objective is to provide comprehensive survey of security Testing methods and Techniques where security Testing Techniques can be classified as: Technical assessment Techniques and non-Technical Assessment Techniques. As a Result of classifying these approaches a direction for integration and future research topic is illustrated. This study presents sophisticated ideas in a simplified form that should be beneficial to both practitioners and researchers in solving software security testing issues.
A survey on design and analysis of robust IoT architecture

The IoT technology creates revolutionary changes in data exchange and device control in different applications. As the IoT network grows it tosses different challenges to engineers and researchers. As the network grows the size of the communicating and processed data also increases. In many cases the clients demands the history of data. To retain the past data large storage disks are in demand. Getting past data may help in data investigation to understand the system behaviour and to estimate its intelligence. Sometimes it is also very important in law-breaking investigation or in case of offence. Then going on adding the storage disks will not satisfy the user demands, buts it pops many other critical issues for both analysists and clients. The increase in disk size and quantity will increase the cost. It may also decrease the performance of the system. For small and individual personal systems this may become an obstacle. For an individual the patriotic IoT may become an expensive and lazy tool to maintain. This creates lots of problem in their daily life. This creates unwanted and unnecessary troubles in the routine life. The large data can be stored in cloud and can be retrieved from cloud data bases. But dynamic reading and storage is a biggest challenge for embedded systems used in IoT. Because of the network speed, data losses in wireless transport and port synchronization problem the data chunks may not arrive at port stand. This need to be intimated to user with acknowledgement signals. For storing real time data entity high speed data RAMs and internal storage devices are embedded in IoT modules. All operations in IoT system are monitored by a microcontroller contained motherboard. In simple and small IoT systems like personal or an individual systems single microcontroller instead of general purpose is sufficient. To reduce the burden on the microcontroller a co-processor can be used. In the present paper a method is proposed to access the data parameters without intervention of main processor. In this method a Direct Memory controller (DMA) is used to fetch the real parameters.
Colostral leukocytes

Leukocytes of human colostrum were studied for their phagocytic activity and ability to migrate in vitro. Samples were collected from healthy females in the first 2 weeks after delivery. Leukocytes were found with great regularity in concentrations of 2200–4100/mm3. These colostral leukocytes displayed glass adhesiveness, amoeboid movement, and the ability to migrate in capillary tubes. The phagocytic activity of colostral leukocytes against nonencapsulated Cryptococcus neoformans approached the normal values of peripheral blood leukocytes. The colostral leukocytes reacted to specific antigen similar to the donors' peripheral blood leukocytes and correlated with the dermal reactivity of the donor. The finding that these leukocytes are in relatively large numbers and possess phagocytic activity supports the concept that this is a naturally occurring in vivo phenomenon and that these cells may protect the breast against invading microorganisms; also, since these cells demonstrate the presence of cell‐mediated hypersensitivity and are normally ingested by the neonate, they may play a role in the development and/or induction of cellular immunity in the neonate.
Mechanical Complications of Long-Term Tesio Catheters

Vascular access catheters such as Tesio-Caths are preferentially inserted in the internal jugular vein and serve as access for hemodialysis. Complications related to the removal of these types of lines are uncommon. We report four patients in whom the tip of the Tesio-Cath broke and was left stuck in the superior vena cava. Although there is no defined limit to the maximum length of stay of vascular access catheters for dialysis, the possibility of catheter entrapment should be considered. It remains to be determined whether removing Tesio-Caths every 16–18 months is beneficial in avoiding this complication.
Cyanocobalamin therapy effect in folic acid deficiency.

Introduction It is currently well established that supraphysiologic doses of folic acid may reverse the hematologic abnormality in patients who are deficient in vitamin B12.1-4On the other hand, the effect of large doses of cyanocobalamin in folic acid-deficient patients has not been clearly determined. Although responses to cyanocobalamin therapy have occasionally been observed in megaloblastic anemia associated with infancy,5A,5Bpregnancy6Aand the puerperium,6A,6Bcirrhosis of the liver,7,8intestinal malabsorption,9and the ingestion of anticonvulsant drugs,10they have often been suboptimal or inadequate, whereas folic acid therapy induces prompt remission. Interpretation of these results have been complicated by a number of factors, including: (1) lack of reliable laboratory measures of deficiency of vitamin B12and folic acid, (2) difficulty in control of dietary folic acid intake, especially in the light of recent evidence indicating the therapeutic efficacy of 25μg. and 50μg.
Adding evidence-based interventions to assertive community treatment: a feasibility study.

OBJECTIVE This 24-month study, conducted in The Netherlands, examined the feasibility of enhancing the effectiveness of assertive community treatment (ACT) by adding evidence-based interventions. METHODS A total of 159 patients were randomly assigned to two ACT teams, one providing standard ACT (N585) and an ACT Plus team that also provided evidence-based interventions (N574): psychoeducation, family interventions, individual placement and support, and cognitive behavioral therapy. The interventions were conducted by psychologists and nurse practitioners working independently from the ACT team. RESULTS Although most patients were judged eligible for each of the four interventions (range 65% to 89%), only 12 of the 74 patients (16%) successfully completed an intervention. Outcomes, such as use of inpatient care, for ACT Plus and standard ACT patients did not differ significantly. CONCLUSIONS Guidelines for the treatment of schizophrenia should consider the feasibility of delivering evidence-based interventions to difficult-to-engage patients.
El control de la oftalmia neonatal gonocócica

RESUMEN: Se realiza un estudio descriptivo en 6 hospitales ginecoobstetricos de la Ciudad de La Habana y 2 de la Provincia La Habana en la primera quincena del mes de mayo de 1995. Se aplicaron tecnicas rapidas de vigilancia en salud como: La entrevista semiestructurada, la observacion no participativa y la revision documental. Las principales conclusiones obtenidas fueron: Los medicos presentaron un nivel de conocimientos adecuado para evitar la transmision de la enfermedad, no sucediendo asi con las enfermeras, las que en su mayoria realizaron el trabajo de forma mecanica. En los hospitales visitados no existe control por parte de los departamentos de neonatologia, epidemiologia, microbiologia y farmacia sobre la calidad de la profilaxis, indicada para evitar la oftalmia neonatal gonococica. Se desconoce la verdadera prevalencia de la gonorrea en las embarazadas, no pudiendose pronosticar el comportamiento de la oftalmia en los ninos, ni proponer los cambios de la profilaxis, no se controla la presencia de cepas resistentes betalactamasas.
In quest of mobility - Honda to develop walking assist devices

Purpose – The purpose of this paper is to describe new walking assist devices Honda is developing.Design/methodology/approach – The exhibition, press release and interview are described. The features of the walking assist devices are presented.Findings – The paper finds that Honda is developing walking assist devices for elderly and disabled people based on its expertise in autonomous walking obtained through the development of Advanced Step in Innovative Mobility.Originality/value – This paper highlights the value of the walking assist devices.
Whole body cooperative tasks and static stability evaluations for a humanoid robot

Human beings utilize a whole body motion such as weight shift to generate a large force while doing heavy works. Momentum is harnessed to increase an action force to the object. This paper discusses whole body cooperative motions of a humanoid robot for heavy works and the static stability during the motion. Pushing a wall and twisting a valve are taken as examples of heavy works in this study. Several whole body motion patterns are examined using a dynamic simulator, which efficiently solves dynamic equations of serial rigid body system using an O(n) algorithm. Static stability is evaluated through simulation results that include external force, joint torques, position of the center of gravity and ZMP, etc.
The rapid rejection of allogeneic lymphocytes by a non-adaptive, cell-mediated mechanism (NK activity).

The fate of allogeneic lymphocytes (AO or DA) transferred to non-immune PVG recipients was studied in the light of previous evidence (Heslop & McNeilage, 1983; Rolstad & Ford, 1983) that allogeneic lymphocytes can be rapidly destroyed in certain strain combinations of rats and mice by a mechanism that is distinct from either T-cell mediated immunity or an alloantibody response. AO lymphocytes injected into PVG recipients were discriminated from syngeneic lymphocytes within 15-30 min of i.v. injection, as testified by the excess release of 51Cr into the lymph plasma of the recipient. The following experiments were intended to distinguish between natural antibody and natural killer (NK) cells as the mechanism responsible for the allogeneic lymphocyte cytotoxicity (ALC) displayed by PVG rats. Nude rats treated from birth with anti-mu chain serum and shown to be lacking B and T lymphocytes, as well as being profoundly deficient in immunoglobulin, displayed more aggressive ALC than did control nude rats which, in turn, showed stronger ALC than did euthymic rats. Serum from PVG nude rats exerted no inhibitory or destructive effect on allogeneic lymphocytes in an antibody-dependent cellular cytotoxicity system, an assay of graft-versus-host activity, or when injected into 3-4-week-old PVG rats which had not yet developed ALC. Treatment of nude rats with anti-asialo GM 1 antiserum depressed ALC and NK activity in parallel, thus adding to a wide range of circumstances in which ALC and NK activity are closely correlated. In conclusion, ALC is implemented by a non-adaptive, cell-mediated mechanism independent of immunoglobulin, but the precise identity of the effector cell in the recipients' lymphatic tissues remains to be settled.
Access to learning materials using different interaction devices: A comparative study based on eye tracking and subjective perception of students

Mobile devices are acquiring a greater presence, being used in many contexts. In this study we aimed to study their use for learning tasks, which are usually carried out under the paradigm of a desktop computer. To this end, we have performed an empirical study in which learning materials are visualized using different supports (conventional computers or mobile phones). The aim of this study was to determine the perception of students on accessing learning materials through different devices, contrasting these opinions with their performance in learning tasks and the metrics provided by an eye tracker device. The results obtained show that the use of mobile devices may not be suitable to support certain types of tasks, such as accessing learning materials.
A Front-End Amplifier With Current Compensation Feedback Input Impedance Booster for Neural Signal Applications

In integrated circuit form, the front-end amplifier (FEA) determines the fidelity of the biosignal detection, signal-to-noise ratio, power consumption and detector size for the future multi-channel neural signal recording systems and applications. Especially for the high-density implantable applications, a higher input impedance reduces the signal attenuation (with respect to the high-impedance miniature electrodes), and lowers the current into the tissue (to avoid the overheating damage). In this paper, an input impedance booster with current compensation feedback technique is proposed, it neutralizes any currents generated at input of FEA without affecting the gain. It substantially yields a high input impedance across process and device mismatches. The proposed front-end circuit is implemented on a <inline-formula> <tex-math notation="LaTeX">$0.18\mu \text{m}$ </tex-math></inline-formula> CMOS process, it achieves an input impedance of approximately 60 <inline-formula> <tex-math notation="LaTeX">$\text{G}\Omega $ </tex-math></inline-formula>, and CMRR of 61 dB with 57 dB PSRR. The input-referred noise is approximately <inline-formula> <tex-math notation="LaTeX">$5.6~\mu \text{v}/\surd $ </tex-math></inline-formula>Hz while consuming <inline-formula> <tex-math notation="LaTeX">$7.6~\mu \text{W}$ </tex-math></inline-formula> in 0. 025mm<sup>2</sup>chip area.
A novel null allele of mouse DSCAM survives to adulthood on an inbred C3H background with reduced phenotypic variability

DSCAMs are cell adhesion molecules that play several important roles in neurodevelopment. Mouse alleles of Dscam identified to date do not survive on an inbred C57BL/6 background, complicating analysis of DSCAM‐dependent developmental processes because of phenotypic variability related to the segregating backgrounds needed for postnatal survival. A novel spontaneous allele of Dscam, hereafter referred to as Dscam2J, has been identified. This allele contains a four base pair duplication in exon 19, leading to a frameshift and truncation of the open reading frame. Mice homozygous for the Dscam2J mutant allele survive into adulthood on the C3H/HeJ background on which the mutation was identified. Using the Dscam2J allele, retinal phenotypes that have variable severity on a segregating background were examined. A neurite lamination defect similar to that described in chick was discovered in mice. These results indicate that, in the retina, additional DSCAM‐dependent processes can be found by analysis of mutations on different genetic backgrounds. © genesis 48:578–584, 2010. © 2010 Wiley‐Liss, Inc.
Efficacy of Pretreatment With the Angiotensin II Type 1 Receptor Blocker UP269-6 and Losartan in the Dog: Effect on Hemodynamics and Ischemia-Reperfusion

Background: Whether pretreatment with the novel oral angiotensin II (AngII) type 1 receptor (AT,R) antagonist UP269-6 (UP) can produce more effective AT,R blockade than losartan (LN) for cardioprotection during ischemia-reperfusion (IR) in the dog has not been deter mined. Methods and Materials: We compared the effect of UP (n = 5) and LN (n = 5) on serial in vivo hemodynamics, AngII pressor responses, and left ventricular (LV) volumes and function (echocardiograms) during escalation to optimal oral dosage over 7 days (day 0 to day 6), and acute IR (15 minutes ischemia, 30 minutes reperfusion) and ex vivo AT,R protein (Western immunoblots) with additional sham (n = 5) and IR (n = 5) controls on day 6. Compared with LN, UP produced greater vasodepression and decrease in diastolic volume during dose escalation and greater inhibition of the AngII pressor response over the range of escalating concentrations (0.05, 0.10, 0.25, and 0.50 μg/kg) on day 6. Acute IR after UP pretreatment resulted in less increase in LV filling pressure and LV diastolic and systolic volumes and greater ejection fraction, although UP and LN had similar effects on AT,R protein. Conclusion: Pretreatment with UP269-6 over 7 days produces more effective pharmacologi cal AT,R blockade and cardioprotection after acute IR than LN in the dog.
Physiologic and Metabolic Benefits of Formulated Diets and Mangifera indica in Fluoride Toxicity

ABSTRACT Fluorosis is a major health problem affecting normal physiological and metabolic functions in people living in endemic fluoride areas. The present work was aimed at investigating the role of basal, high carbohydrate low protein (HCLP) and high protein low carbohydrate (HPLC) diets and Mangifera indica fruit powder as a food supplement in fluoride-induced metabolic toxicity. Exposure to fluoride resulted in elevation of plasma glucose levels, ACP, ALP, SGPT, SGOT, and hepatic G-6-Pase activities, plasma and hepatic lipid profiles with decreased plasma protein, HDL-C, hepatic glycogen content and hexokinase activity in basal, HCLP and HPLC diet fed albino rats. However among the three diets tested, HPLC diet was found to be relatively, a better metabolic regulator. All the three formulated diets (basal, HCLP and HPLC) supplemented with mango fruit powder (5 and 10 g), decreased plasma glucose content, ACP, ALP, SGPT, SGOT and hepatic G-6-Pase activities and plasma as well as hepatic lipid profiles. These diets also elevated the hepatic glycogen content and hexokinase activities. These effects however, were prominent with the HPLC diet supplemented with mango fruit powder and, among the two doses of mango fruit powder, the higher dose (10 g) yielded more promising results. It is surmised that the micronutrients and phytochemicals present in the diets and the mango fruit could be responsible for attenuation of fluoride-induced metabolic toxicity.