Miracle-dz/UniFAR-FTUs huggingface dataset:
A coarse-to-fine scheme for groupwise registration of multisensor images

Ensemble registration is concerned with a group of images that need to be registered simultaneously. It is challenging but important for many image analysis tasks such as vehicle detection and medical image fusion. To solve this problem effectively, a novel coarse-to-fine scheme for groupwise image registration is proposed. First, in the coarse registration step, unregistered images are divided into reference image set and float image set. The images of the two sets are registered based on segmented region matching. The coarse registration results are used as an initial solution for the next step. Then, in the fine registration step, a Gaussian mixture model with a local template is used to model the joint intensity of coarse-registered images. Meanwhile, a minimum message length criterion-based method is employed to determine the unknown number of mixing components. Based on this mixture model, a maximum likelihood framework is used to register a group of images. To evaluate the performance of the proposed approach, some representative groupwise registration approaches are compared on different image data sets. The experimental results show that the proposed approach has improved performance compared to conventional approaches.
Inhibition of Ethanol-Induced Liver Disease in the Intragastric Feeding Rat Model by Chlormethiazole (44545)

The purpose of this Investigation was to assess the effect of chlormethiazole treatment on liver damage In the experimental rat Intragastric ethanol-feeding model of alcoholic liver disease. Chlormethiazole has been used in the treatment of alcoholic withdrawal and has been shown to inhibit cytochrome P4502E1. Since treatment of experimental alcoholic liver disease with CYP2E1 inhibitors had an ameliorating effect on liver injury in the rat, chlormethiazole was used to see if it had a similar effect. Rats fed ethanol for 2 months had significantly less liver injury when chlormethiazole was added to the diet, fed intragastrically. The CYP2E1 apoprotein levels, which were increased by ethanol feeding, were also increased when chlormethiazole was fed with ethanol. Chlormethiazole inhibited the increase in the ethanol-induced CYP2E1 activity In vivo, as measured by chlorzoxazone 6-hydroxylation, but did not affect the level of CYP2E1 apoprotein. Likewise, the reduction in proteasome proteolytic enzyme activity produced by ethanol feeding was blunted in chlormethiazole-fed rats. These results support the conclusion that chlormethiazole treatment partially protects the liver from injury by inhibiting CYP2E1 activity In vivo.
Assessment of depression anxiety and stress among the anaemia in pregnant women attending selected health care facilities in Sebha, Libya

In pregnancy, anaemia has significant impact on health of the foetus as well as that of the mother. 20% of maternal deaths in Africa have been attribut ed to anaemia. The WHO report in 2006, the preval ence of anaemia is highest in Africa. Depression, anxiety and stress were significant factor which aff ects the motherchild bonding ,growth and development. Objectives : The aim of the study were to determine the degree of anaemia among pregnant women and to assess the depression, anxiety and stress amo ng the anaemia in pregnancy women. Material and Methods: A descriptive study was conducted to assess the dep ression, anxiety and stress among anaemia in pregnant women attending selected heal th care facilities in Sebha, Libya. Purposive sampl ing technique was employed to select sample and it consisted of 2 58 anaemic pregnant women. Data was collected using structured interview schedule. Results : Findings of the study showed that 118 (45.74%) pr egnant women had mild anaemia; 122 ( 47.28%) pregnant women had moderate anaemia and 18 ( 6.98%) pregnant women had severe anaemia a nd majority of 146 (56.59%) anaemic pregnant women had normal depression scale ; maximum 193 (74.42%) anaemic pregnant women had normal anxiety scale and m ajority 177 (68.60%) anaemic pregnant women had normal stress scale. There was no significant associa tion between depression, anxiety , stress and haemoglobin level during pregnancy. Conclusion: Findings of the study indicated the need to conduct frequent assessment of depression, anxiety an d stress among the anaemia in pregnancy women. Awareness programmes should be conducted among the pregnant women for their Promotion of health.
Differentiating levels of surgical experience on a virtual reality temporal bone simulator

Objective Virtual reality simulation is increasingly being incorporated into surgical training and may have a role in temporal bone surgical education. Here we test whether metrics generated by a virtual reality surgical simulation can differentiate between three levels of experience, namely novices, otolaryngology residents, and experienced qualified surgeons. Study Design Cohort study. Setting Royal Victorian Eye and Ear Hospital. Subjects and Methods Twenty-seven participants were recruited. There were 12 experts, six residents, and nine novices. After orientation, participants were asked to perform a modified radical mastoidectomy on the simulator. Comparisons of time taken, injury to structures, and forces exerted were made between the groups to determine which specific metrics would discriminate experience levels. Results Experts completed the simulated task in significantly shorter time than the other two groups (experts 22 minutes, residents 36 minutes, and novices 46 minutes; P = 0.001). Novices exerted significantly higher average forces when dissecting close to vital structures compared with experts (0.24 Newton [N] vs 0.13 N, P = 0.002). Novices were also more likely to injure structures such as dura compared to experts (23 injuries vs 3 injuries, P = 0.001). Compared with residents, the experts modulated their force between initial cortex dissection and dissection close to vital structures. Using the combination of these metrics, we were able to correctly classify the participants’ level of experience 90 percent of the time. Conclusion This preliminary study shows that measurements of performance obtained from within a virtual reality simulator can differentiate between levels of users’ experience. These results suggest that simulator training may have a role in temporal bone training beyond foundational training.
Asociación de depresión y ansiedad en pacientes con síndrome de intestino irritable

Dr. Mauricio Alberto Cruz Ruíz,* Rubí Berenice Ortíz Herrera,** Damaríz Muñiz Jurado,** José Luís Padierna Luna*** * Gastroenterólogo adscrito Hospital General de Zona 4 IMSS, Celaya, Gto. , **Médico interno de Pregrado, ***Coordinador de Investigación y Educación en Salud. HGZ 4 IMSS Celaya, Gto. Correspondencia: Dr. Mauricio A. Cruz Ruíz. Calle Aldama No. 227, Int. 301, Zona Centro, Celaya, Gto. C.P. 38000. Tel. : (01461)613-0142, fax: (01461)6129935. Correo electrónico: a4611563116@prodigy.net. mx
Femmes à risques : évolution de l'oncogénétique en pratique quotidienne : Comment définir une femme à risque en 2006 ?

Estimer le risque pour une femme de développer un cancer du sein n’est pas toujours aisé, bien que des modèles aient été établis à partir d’études de grandes populations, comme les modèles de Gail [1] et de Claus [2]. Néanmoins, il est une situation où les risques sont plus clairs : celle des femmes ayant une mutation constitutionnelle (MC) d’un gène BRCA1 ou BRCA2. L’identification de ces gènes, il y a une dizaine d’années, a été une avancée majeure dans l’estimation des risques de cancer du sein. La recherche de mutation constitutionnelle BRCA est maintenant de pratique médicale courante. Quand une mutation est identifiée dans une famille, il est possible de proposer une prise en charge spécifique, en fonction du niveau de risque (c’est-à-dire de la présence ou de l’absence d’une mutation constitutionnelle). Les tests présymptomatiques de prédisposition ont donc pour ambition d’optimiser la prise en charge des personnes à haut risque et de rassurer celles qui ne s’avèrent pas prédisposées. S’il existe à l’heure actuelle des lignes directrices pour la prise en charge de ces personnes prédisposées, chaque cas reste particulier. Les retombées individuelles et familiales, médicales et psychosociales de la connaissance d’un statut génétique et du risque de cancer doivent être appréciées [3, 4].
Diagnosis and assessment of pulmonary arterial hypertension

The diagnosis and assessment of pulmonary arterial hypertension (PAH) is a rapidly evolving area, with changes occurring in the definition of the disease, screening and diagnostic techniques, and staging and follow-up assessment. After 4th World Symposium on pulmonary hypertension (PH) which took place in Dana Point in early 2008, the definition of PH has been simplified (mean pulmonary artery pressure 25 mmHg) based on currently available evidences. The diagnosis of PH involves two stages: detection (determining the cause of a patient's symptoms, or to detect the presence of PAH in a high-risk patient) and characterization (determining the specific clinical context of the PH, including causal factors, associated diseases or substrates and hemodynamic perturbations). Echocardiography and right heart catheterization have been main diagnostic method in PAH. Also, there has been progress in imaging techniques and biomarkers used to screen patients for the disease and to follow up their response to therapy. Useful tools to predict outcome include functional class, exercise capacity, pulmonary hemodynamics, acute vasoreactivity, right ventricular function, as well as brain natriuretic peptide, endothelin-1, and so on. As new therapies have been developed for PAH, screening, prompt diagnosis, and accurate assessment of disease severity have become increasingly important. A clear definition of PH and the development of a rational approach to diagnostic assessment and follow-up using both conventional and new tools will be essential to advance proper treatment of patients.
Some Deficiency Diseases and Leprosy. 1

Owing to the numerous and accurate observations which have been made in regard to beri-beri, it is now generally recognized to be one of the deficiency diseases. It is found largely among those who subsist mainly on rice from which the pericarp and aleurone have been removed, while recovery may result when unpolished rice is substituted for polished. A diet chiefly composed of white bread can also induce the affection,'although Sir F. Taylor says this does not often occur, as it is rarely or fiever the only food [1]. This circumstance seems to afford a clue to its causation, as it shows at any rate that it may be induced by more than one unsatisfactory kind of diet. Numerous investigations have lately been made in regard to so-called tritamines, but the characteristics and chemical composition of any such bodies do not appear to be at present determined. Whatever the particular defect in dietary may be, beri-beri is comparatively infrequent in the more highly civilized countries. Dr. W. H. Willcox noted during the recent campaign in Mesopotamia that it occurred in British troops whose diet mainly consisted of bully beef and white flour, and that it did not occur among Indian troops who lived on whole cereal flour and different pulses [2]. The difficulties that were encountered in supplying these troops with sufficient variety, and particularly of fresh foods, can be readily realized. Something in foods, whether vitamines or whatever it may later be found exactly to be, is lacking in some degree in tinned meats and probably also in dried vegetable products. Although the whole wheat berry and unpolished rice may be needed to supply effective nutrition when either of these is almost or quite the only food, it appears to be unnecessary to burden the digestive organs with husks and other material which are
New Sounds in Primary Teacher Education

Research over the past twenty years has indicated that effective teaching of the Creative Arts (Music, Dance, Drama and Visual Arts) in many schools is not apparent. Despite many national and state-based reports into Arts Education and the ensuing recommendations, many generalist primary school teachers still lack the confidence, resources and training to teach a sound Creative Arts Program. This paper briefly looks at the low priority music education has had in many Australian schools, then suggests ways of developing an integrated approach to teaching the Creative Arts. This integrated approach has been tried in a Teacher Education program at the University of Western Sydney, Macarthur, and results have indicated that teachers' attitudes and practices to teaching the Creative Arts have changed significantly after completing this subject.
Predictors Of Early Mortality And Bad Outcome In Ischemic Stroke (P3.072)

Background and purpose: stroke is a major public health problem and identification of predictors of mortality and bad outcome crucial in decision making regarding care provision. We assessed clinical variables related to 30-day mortality and bad outcome in a quality-of-care stroke secondary prevention program. Methods: consecutive acute ischemic stroke patients were included in the analysis. Demographic data, vascular risk factors profile and disability (modified Rankin scale) were evaluated one month after the event, and were analyzed in two groups of patients: 1) bad oucome (death or m-Rankin > 1), and 2) good outcome (those with none of these characteristics). Results: we analyzed data of the 1194 ischemic stroke patients included between December 2006 and December 2013. Pre-stroke vascular risk factor profile was: hypertension 82[percnt], dislipidemia 65[percnt], obesity 48[percnt], metabolic syndrome 42[percnt], smoking 38[percnt], atrial fibrillation 17[percnt], diabetes 14[percnt], history of stroke 16[percnt], coronary heart disease 17[percnt], peripheral vascular disease 11[percnt]. In the univariate analysis bad outcome was associated with age, female sex, NIHSS > 10 points at admission , atrial fibrillation, previous stroke, obesity , renal failure, and elevated pulse pressure at admission and hospitalization > 1week . Predictors of bad outcome in multivariate analysis were: female sex (OR 1.93, 95[percnt]CI 1.39-2.67; p 0.0001), age > 80 years (OR 1.80, 95[percnt]CI 1.80-3.42; p 0.0001), NIHSS > 10 (OR 7.01, 95[percnt]CI 3.59-13.6; p 0.0001), hospitalization > 1 week (OR 4.53, 95[percnt]CI 3.21-7.58; p 0.0001), history of stroke (OR 1.86, 95[percnt]CI 1.19-2.88; p 0.006), atrial fibrillation (OR 1.66, 95[percnt]CI 1.60-2.49; p 0.01). Conclusion: identifying predictors of early mortality or post-stroke disability is mandatory in order to recognize opportunities of improvement and develop strategies for clinical care in this specific subgroup of patients. A multidisciplinary approach is essential to reduce clinical complications and to improve follow up after the hospitalization period. Disclosure: Dr. Luzzi has nothing to disclose. Dr. Zurru has nothing to disclose. Dr. Alonzo has nothing to disclose. Dr. Brescacin has nothing to disclose. Dr. Pigretti has nothing to disclose. Dr. Camera has nothing to disclose. Dr. Colla Machado has nothing to disclose. Dr. Waisman has nothing to disclose. Dr. Cristiano has received personal compensation for activities with Bayer, Biogen Idec, Merck & Co., Inc., and Novartis.
Tablet Usage From Teachers’ Perspectives In the Learning-Teaching Process

Innovations in education continue by depending on the developing conditions and technology. As in several countries, various projects are being implemented in Turkey, as well, in order to increase the quality of education. Foremost among these is the Project of Increasing Opportunities and Technology Improvement Movement (PIOTIM) (FATIH in Turkish). In this study, it was aimed that the views of the teachers (f=57) working in the high schools in Tekirdag where tablet PCs were delivered in 2014-2015 school year with respect to the positive and negative aspects of tablet usage in the learning-teaching process and their suggestions for a more efficient way of use of these tablets be received. The qualitative research method was used in this study. In total, there were 16 themes agreed upon, whereas there was no consensus over 1 theme. The data reliability was calculated as (p)=16/(16+1)x100=94,1 with the formula, Consensus / (Dissensus + Consensus) x 100. As the result of the research, it was found that the tablet usage in the learning-teaching process had negative aspects apart from its positive qualities and that some of those negative aspects could be made positive through rectification.
Pedestrian detection algorithm in traffic scene based on weakly supervised hierarchical deep model

The emergence and development of deep learning theory in machine learning field provide new method for visual-based pedestrian recognition technology. To achieve better performance in this application, an improved weakly supervised hierarchical deep learning pedestrian recognition algorithm with two-dimensional deep belief networks is proposed. The improvements are made by taking into consideration the weaknesses of structure and training methods of existing classifiers. First, traditional one-dimensional deep belief network is expanded to two-dimensional that allows image matrix to be loaded directly to preserve more information of a sample space. Then, a determination regularization term with small weight is added to the traditional unsupervised training objective function. By this modification, original unsupervised training is transformed to weakly supervised training. Subsequently, that gives the extracted features discrimination ability. Multiple sets of comparative experiments show that the performance of the proposed algorithm is better than other deep learning algorithms in recognition rate and outperforms most of the existing state-of-the-art methods in non-occlusion pedestrian data set while performs fair in weakly and heavily occlusion data set.
A Follow-Up Study of Childhood Nasopharyngeal Radium Irradiation in Washington County, Maryland

In 1978 an epidemiologic study exploring the health consequences of nasopharyngeal radium irradiation among individuals treated for adenoid enlargement in Washington County, Maryland, found an excess risk of brain tumors and a deficit of female breast cancers. The study population included all persons first seen at the Washington County Clinic for the Prevention of Deafness in Children from 1940 to January 1, 1960. We will continue the follow-up of irradiated and nonirradiated patients to (1) assess the risk of brain tumors and other neoplasms of the head and neck developing during a 40-year period, (2) assess hormone-related disorders resulting from irradiation of the pituitary gland, and (3) compare cancer incidence and mortality rates among exposed and nonexposed groups. Of the 2135 persons eligible for this study, 93.5% have been traced, and 90% have replied to a mailed questionnaire that elicits information on demographic characteristics, reproductive and medical history, infertility, and other sources of radiation exposure. Information on cancer incidence and mortality is being obtained from the Washington County Cancer Registry and death certificate flies from Washington County and the Social Security Administration. Statistical methods to be used in the data analysis include standardized mortality ratios, standardized cancer incidence ratios, and Kaplan-Meier survival analysis.
Protéomique par SELDI-TOF-MS des maladies inflammatoires articulaires: identification des protéines S100 comme protéines d'intérêt

La proteomique clinique est une approche technologique qui, en etudiant l'ensemble des proteines exprimees, met l'accent sur une description dynamique de la regulation cellulaire en decelant des evenements moleculaires associes au developpement de maladies. Son but est d'identifier de nouveaux marqueurs biologiques ou de nouvelles cibles therapeutiques liees a ces pathologies. C'est une approche multidisciplinaire a la croisee des chemins entre la medecine, la biologie, la bioanalyse et la bioinformatique; et c'est grâce a une collaboration etroite entre les services experts dans ces domaines que plusieurs etudes proteomiques portant sur des maladies inflammatoires articulaires ont ete menees sur le site du CHU et de l'Universite de Liege avec GIGA-Research comme interface logistique et fonctionnelle. Le but poursuivi au travers de ces etudes est decrit dans cet article selon trois axes de recherche relatifs a l'identification de marqueurs sensibles et specifiques d'une pathologie, d'un mecanisme biologique commun ou encore de la reponse au traitement qui lui est apportee. Ce travail a ete presente dans le cadre de la reunion Synthese 2009.
Dynamic optimum design of a 3UPS-PRU parallel robot

This article deals with the methodology of the dynamic optimum design of the one translational and three rotational degrees of freedom parallel robots while considering the rigid-body dynamic property. The dynamic optimum design of the 3UPSPRU (underlined P denotes an active prismatic joint driven by a servomotor) parallel robot is presented while considering the constraints on the installation dimension, joint rotation angle, and the interference. The maximum driving torque and the maximum driving power of the actuating joints are taken as the objective functions in the dynamic optimum design, respectively. The physical meanings of the objective functions are the maximum driving torque and the maximum driving power of the actuating joints when the moving platform translates along the z-axis in the maximum linear acceleration a max, rotates about an arbitrary axis in the maximum angular acceleration max, translates along the z-axis in the maximum linear velocity v max, and rotates about an arbitrary axis in the maximum angular velocity ω max at the same time. The object of the dynamic optimum design is to minimize the maximum driving torque or the maximum driving power by employing worst case criterion. In the predefined design task, the results of the dynamic optimum design of the 3UPS-PRUparallel robot are the same when taking the maximum driving torque and the maximum driving power as the objective functions. The phenomenon can be verified by the fact that the distributions of the maximum driving torque and the maximum driving power are very similar to each other. The robot dimension has also been taken into account in the dynamic optimum design of the 3UPS-PRU parallel robot due to the consideration of the building cost and the miniaturization. The example of the dynamic optimum design of the 3UPS-PRU parallel robot is presented in the simulation. The conclusions are provided at the end of the article.