Miracle-dz/UniFAR-FTUs huggingface dataset:
Horse phenotyping based on video image analysis of jumping performance for conservation breeding

Background Many horse breeds in the world are reserved as genetic resources; however, their characteristics seem to be insufficiently clarified, especially in terms of horse performance. Two jumping ability evaluation methods have been used to compare different types of performance breeds and on this basis their applicability for precision phenotyping has been determined. Methods Jumping data of 186 young Polish Warmblood stallions (27 with an endangered status) bred for sport and multipurpose use was collected during their performance tests organised under identical environmental conditions following the same guidelines. Jumping data consisted of objective measurements of free jumping parameters and the marks for jumping. Video recordings of 514 jumps (73 records for 27 stallions with an endangered status) were collected using a digital Panasonic AG-EZ 35 camera (25 fr/sec). Filming was recorded during a free jumping test in the line on a doublebarre obstacle (100–120 cm × 100 cm). Spatial and temporal variables of the jump were measured. The analysis of variance was performed (SAS, General Linear Model and Mixed procedures) using the statistical model, which included the random effect of the horse and fixed effects of the year of test, breeding status, height of jump and the successive number of the jump for objective kinematic data. The fixed effects of the year of test and breeding status were included in the model for subjective performance test data. Results Performance marks for free jumping were lower in the endangered group of stallions in the trainers’ opinion (p ≤ 0.05), while no statistically significant differences were found in the judges’ opinions. Statistically significant differences in jumping variables were measured for the bascule points—the elevations of the withers and croup were higher in the endangered group (p ≤ 0.001) and the take-off time was prolonged (p ≤ 0.05), which explained the subjective evaluation. Discussion The use of objective evaluation methods provides important information for practice, as phenotypic differences between horses may be unclear in the subjective evaluation. The objective evaluation should be used to characterise the performance potential of different breeds, because the information from the evaluators might not be consistent. Such characteristics should be recorded at least for every new population.
Cost-effectiveness and budget impact analysis of viscosupplementation with hylan G-F 20 for knee and hip osteoarthritis

Purpose To estimate the cost-effectiveness and budget impact of viscosupplementation with one intra-articular (IA) injection of 6 mL hylan G-F 20 (Synvisc-One®) and with three injections of 2 mL hylan G-F 20 (Synvisc®3×2) in knee osteoarthritis (OA) patients compared with conventional support therapy (CST – eg, NSAIDs and acetaminophen) and the cost-effectiveness of one IA injection of 2 mL hylan G-F 20 (Synvisc®1×2) in hip OA patients compared with CST from an Italian Health System perspective. Methods The model used was a Markov model with states for stages II–IV on the Kellgren–Lawrence scale and runs on 6-month cycles over a 5-year time horizon. A 3.5% discount was applied to both costs and utilities. Direct costs were determined from the perspective of the Italian National Health Service. A one-way and probabilistic sensitivity analysis was conducted for both comparisons. Results Hylan G-F 20 1×6 mL and hylan G-F 20 3×2 mL for knee OA were very likely to be cost-effective when compared to acetaminophen (ICER = €3,160.61 and €3,845.81 per QALY, respectively) and NSAIDs as both ICERs are below €25,000. The hip OA treatment by hylan G-F 20 1×2 mL was dominant compared to NSAIDs and very likely compared to acetaminophen. The results of the cost-effectiveness analysis were confirmed by one-way sensitivity analysis. The budget impact analysis for knee and hip OA showed a small increase in expenditure during 5 years. Conclusions Hylan G-F 20 1×6 mL/hylan G-F 20 is a cost-effectiveness treatment compared to NSAIDs and acetaminophen in the treatment of knee/hip OA in Italy. The treatment of hip and knee OA resulted in cost-saving with hylan G-F 20 1×2 mL and economically sustainable with hylan G-F 20 1×6 mL. However, Real Word Evidence studies should be conducted in order to estimate costs associated with both prosthetics and to understand the reduction of physiotherapy and medication due to hylan G-F 20.
Transient Contrast Neurotoxicity After Percutaneous Coronary Intervention Mimicking Subarachnoid Hemorrhage in a Patient With Chronic Kidney Disease

Transient contrast neurotoxicity is a rare but well-recognized complication of angiography that is due to neurotoxicity of the contrast agent. Patients with renal dysfunction may be inclined to develop contrast medium neurotoxicity due to delayed elimination of the contrast medium in renal metabolism. In this report, we present an unusual case of transient neurotoxicity in a patient with severe chronic kidney disease following percutaneous coronary intervention mimicking clinically and radiologically subarachnoid hemorrhage. The patient’s clinical symptoms improved rapidly and fully recovered after hemodialysis and conservative treatment. We believe that performing early hemodialysis is an effective treatment to improve symptoms in end-stage renal disease patients with contrast-induced encephalopathy.
Analysis of Dietary Factors Affecting Body Mass Index in Elderly Patients With Type 2 Diabetes Mellitus

Background Body mass index (BMI) is correlated with the outcomes of various metabolic and pathological conditions. To elucidate the factors affecting BMI in elderly persons, we studied elderly persons with and without diabetes mellitus for BMI management target values using receiver operating characteristic (ROC) analysis. Methods We conducted a dietary survey targeting 60 elderly outpatients with type 2 diabetes mellitus (diabetes group, 70.1 ± 7.8 years) and 66 elderly persons who participated in a health class offered by the municipality (health class group, 72.5 ± 5.7 years). Results In the diabetes group, positive correlations were observed between BMI and several variables including blood glucose levels (all P < 0.05), whereas BMI had negative correlations with the third principal component (positive weight for oils and fats). In addition, BMI was negatively correlated with the intake of oils and fats. In the health class group, BMI was positively correlated (all P < 0.05) with grip strength/sixth principal component (positive weight for sweets)/condiments. An analysis of dietary patterns revealed that dietary factors correlated with BMI in each group. The cutoff value of BMI was suggested to be near the normal upper limit or slightly higher in the subject group. Conclusion We considered that BMI management was useful as an indicator for maintaining grip and muscle strength in elderly persons and as an indicator for diabetes care management. From the present study, we may propose the utility of a careful dietary survey as one of the approaches for these aims.
Clinical utility of ramucirumab in non-small-cell lung cancer

Abstract Lung cancer is the leading cause of cancer-related mortality worldwide. Non-small-cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases and approximately 70% of patients with NSCLC have locally advanced or metastatic disease at presentation. In NSCLC patients with advanced or metastatic disease, second line treatment with chemotherapy is associated with a poor response rate. In this article, we have reviewed the role of ramucirumab in patients with NSCLC. Ramucirumab is not current standard of care in the first line setting in the treatment of advanced or metastatic NSCLC, based on phase II data which did not show any progression-free survival (PFS) and overall survival (OS) benefit when ramucirumab was compared with non-ramucirumab arm. The REVEL study was a phase III, placebo-controlled trial which included patients with stage IV NSCLC who had progressed during or after platinum-based chemotherapy, with or without bevacizumab. Median OS was 9.1 months vs 10.5 months (HR 0.86, 95% CI 0.75–0.98) in the placebo and ramucirumab group respectively. Seventy-nine percent of patients in ramucirumab arm and 71% of patients in non-ramucirumab arm had grade ≥3 treatment-related adverse events. The addition of ramucirumab to docetaxel can be considered in younger patients with good performance status as a second line treatment option. Additionally, combined blockage of the VEGFR and EGFR pathway has been utilized to overcome resistance to EGFR therapy. The RELAY trial was a phase III, placebo-controlled trial which included patients with sensitizing EGFR mutation positive stage IV NSCLC. Patients were randomized to either ramucirumab plus erlotinib or erlotinib. The trial showed that the combination therapy showed superior PFS benefit.
Loss of Cirbp expression is correlated with the malignant progression and poor prognosis in nasopharyngeal carcinoma

Purpose: The correlation of cold-inducible RNA-binding protein (Cirbp) expression with clinicopathological features including patient prognosis in nasopharyngeal carcinoma (NPC) was investigated. Methods: The expression of Cirbp in NPC cell lines and tissue specimens was examined by qRT-PCR or immunohistochemistry (IHC). Results: Immunohistochemistry (IHC) results showed that high Cirbp expression was detected in 61 of 61 non-cancerous nasopharyngeal squamous epithelial biopsies, whereas the significantly reduced expression of Cirbp was observed in NPC specimens. In addition, IHC assay for Cirbp protein illustrated that the cells of 177 NPC samples and nasopharyngeal squamous epithlial cells displayed strong signals in nuclei and faint signals in cytoplasm, whereas Cirbp protein is mainly detected in the cell’s cytoplasm in many other cancers. More importantly, TNM classification displayed that the low expression of Cirbp was more frequently observed in T3-T4, N2-N3, M1 and III-IV NPC biopsies, and undifferentiated carcinoma (UDC) than T1-T2, N0-N1, M0 and I-II tumors, and differentiated nonkeratinizing carcinoma (DNKC), suggesting that Cirbp loss is a key molecular event in advanced cases of NPC. Kaplan–Meier survival analysis indicated that NPC patients showing lower Cirbp expression had a significantly shorter overall survival time than those with high Cirbp expression. Multivariate analysis suggested that the level of Cirbp expression was an independent prognostic indicator for NPC survival. Finally, we revealed a significant positive association between Cirbp expression and E-cadherin, and a notable negative correlation between Cirbp expression and Ki67 labeling index in NPC biopsies. Conclusion: Collectively, these findings demonstrate that loss of Cirbp expression is correlated with malignant progression and poor prognosis in NPC.
Atypical antipsychotics-induced metabolic syndrome and nonalcoholic fatty liver disease: a critical review

Abstract The atypical antipsychotics (AAPs) have been used as first-line drugs in psychiatric practice for a wide range of psychotic disorders, including schizophrenia and bipolar mania. While effectively exerting therapeutic effects on positive and negative symptoms, as well as cognitive impairments in schizophrenia patients, these drugs are less likely to induce extrapyramidal symptoms compared to typical antipsychotics. However, the increasing application of them has raised questions on their tolerability and adverse effects over the endocrine, metabolic, and cardiovascular axes. Specifically, AAPs are associated to different extents, with weight gain, metabolic syndrome (MetS), and nonalcoholic fatty liver disease (NAFLD). This article summarized clinical evidence showing the metabolic side effects of AAPs in patients with schizophrenia, and experimental evidence of AAPs-induced metabolic side effects observed in animals and cell culture studies. In addition, it discussed potential mechanisms involved in the APPs-induced MetS and NAFLD.
CrowDevBot: A Task-Oriented Conversational Bot for Software Crowdsourcing Platform (S)

—With the trends of developing software on the Internet, many software crowdsourcing platforms are emerging. They attract a lot of developers to bid for crowdsourced projects and develop software systems collaboratively. In this paper, we present CrowDevBot, a task-oriented conversational bot for software crowdsourcing platform , that aims to assist online users in completing crowdsourcing-related tasks in a more natural manner. The key idea of CrowDevBot is to: (1) combine a rule-based method and an SVM-NaiveBayes-C4.5 integrated learning method to discover users’ intention; (2) employ an integrated CRF (conditional random ﬁeld) method with novel features to improve the performance of slot ﬁlling; and (3) leverage a software service knowledge base to unify entity names and predeﬁne the key slots of user query. We implement CrowDevBot and integrate it into JointForce, an IT software crowdsourcing platform in China. To the best of our knowledge, this is the ﬁrst time that a task-oriented conversational bot is practically used in software crowdsourcing platform(s). We evaluated our approach on real data set from JointForce. The results show that our intention detecting method achieves F1-score of 87% on the limited training data. For the slot ﬁlling, the F1-score of our integrated CRF model reaches 82%, 8% higher than that of the normal CRF model. Index Terms —Task-oriented conversational bot, software crowdsourcing
Constructing a Knowledge Base of Coding Conventions from Online Resources

—Coding conventions are a set of coding guidelines used by software developers to improve the readability of source code, increase software maintainability, and promote the reuse of coding patterns. In this paper, we introduce CCBase , a knowledge base of coding conventions, that was constructed from online resources. Specifically, CCBase was constructed as follows. We designed the ontology of the coding convention domain, crawled data related to coding conventions from a variety of online resources, and then extracted entities and relations using an NLP-enabled rule matching method. To uncover the latent relations, we further proposed a similarity metric to reveal the similar-to and relate-to relations, and developed a RCE algorithm to establish a unified type hierarchy of coding conventions. The resulting knowledge base contains 3139 coding conventions for Java and C++, with 3761 entities and 767 relations. Furthermore, we have extended the usability of CCBase by developing a question answering system on the base. We have conducted experiments to evaluate CCBase. The experimental results show that CCBase has a wide coverage on entities and relations in coding conventions domain, and the QA system achieves an F1 score of 84.5% on 214 questions raised in StackOverflow.
All About Phishing: Exploring User Research through a Systematic Literature Review

Phishing is a well-known cybersecurity attack that has rapidly increased in recent years. It poses legitimate risks to businesses, government agencies, and all users due to sensitive data breaches, subsequent financial and productivity losses, and social and personal inconvenience. Often, these attacks use social engineering techniques to deceive end-users, indicating the importance of user-focused studies to help prevent future attacks. We provide a detailed overview of phishing research that has focused on users by conducting a systematic literature review of peer-reviewed academic papers published in ACM Digital Library. Although published work on phishing appears in this data set as early as 2004, we found that of the total number of papers on phishing (N = 367) only 13.9% (n = 51) focus on users by employing user study methodologies such as interviews, surveys, and in-lab studies. Even within this small subset of papers, we note a striking lack of attention to reporting important information about methods and participants (e.g., the number and nature of participants), along with crucial recruitment biases in some of the research.
Gain and loss of subcutaneous and abdominal fat depot mass from late pregnancy to 100 days in milk in German Holsteins

Abstract This research paper addresses the hypothesis that in times of negative energy balance around parturition in dairy cattle, lipids stored in adipocytes are mobilised in a more intensive manner out of the abdominal depots than out of the subcutaneous adipose tissues. Furthermore, the impact of niacin supplementation and energy density of the ration on adipose tissue mass gain and loss was assessed. Absolute masses of subcutaneous (SCAT), retroperitoneal (RPAT), omental (OMAT), mesenterial (MAT) and abdominal adipose tissue as a whole (AAT) were estimated by ultrasonography at −42, 3, 21 and 100 DIM. Absolute and relative daily gain during dry period (−42 to 3 DIM) and loss in fresh cow period (3 to 21 DIM) and early lactation period (22 to 100 DIM) were calculated. Feeding regime neither by niacin nor by energy density exerted any effect on adipose tissue masses. The AAT was always bigger than SCAT, but RPAT, OMAT and MAT did not differ amongst each other. All depot masses showed similar patterns with an increase during dry period and a decrease after calving. In fresh cow period AAT absolutely and relatively lost more mass than SCAT. This confirms that AAT is more intensively mobilised than SCAT during that time span. Further absolute daily gain during dry period was strongly negatively correlated with absolute daily loss during fresh cow period. This underlines the impact of individual body condition on adipose mobilisation in periparturient dairy cows. According to these results, it has to be taken into account that the largest amount of fat mobilised in the fresh cow period origins from AAT. This might impact the pattern of adipose derived metabolites and metabolic effectors interacting in physiological and deregulated adaptation to negative energy balance.
Overview on Percutaneous Therapies of Disc Diseases

Low back pain is an extremely common pathology affecting a great share of the population, in particular, young adults. Many structures can be responsible for pain such as intervertebral discs, facet joints, nerve roots, and sacroiliac joints. This review paper focuses on disc pathology and the percutaneous procedures available to date for its treatment. For each option, we will assess the indications, technical aspects, advantages, and complications, as well as outcomes reported in the literature and new emerging trends in the field.
Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin-1 (SIRT1) Independent Manner.

SCOPE Maternal obesity has been associated with increased placental lipotoxicity and impaired mitochondrial function. Sirtuin-1 (SIRT1) is an important regulator of both lipid metabolism and mitochondrial biogenesis. The present study aimed to determine whether supplementation of the maternal diet with eicosapentaenoic acid (EPA) could decrease placental lipid deposition and improve antioxidant ability, in a SIRT1-dependent manner. METHODS AND RESULTS Pregnant SIRT1+/- mice (mated with male SIRT1+/- ) were fed a high-fat diet consisting with 60% of the kcal from fat, or an equienergy EPA diet for 18.5 d. Supplementation with EPA significantly changed maternal plasma, placental, and fetal fatty acid composition, and decreased placental and fetal lipid content.In addition, placental antioxidant capacity and lipid peroxidation products were increased, placental UCP1 and PGC1α expression were activated, and mitochondrial swelling decreased. While SIRT1 deficiency had little effect on placental fatty acid composition and lipid content, decreased fetal lipid deposition was observed, placental PGC1α expression decreased, mitochondrial swelling increased and placental T-SOD activity increased. Both EPA and SIRT1 had no effect on BODIPY-FL-C16 uptake. Interestingly, there was no significant interaction between diet and genotype. CONCLUSION Maternal EPA feeding decreases placental lipid deposition and improves placental oxidative stress homeostasis independent of SIRT1. This article is protected by copyright. All rights reserved.
Touchscreens for Aircraft Navigation Tasks: Comparing Accuracy and Throughput of Three Flight Deck Interfaces Using Fitts’ Law

Objective Use Fitts’ law to compare accuracy and throughput of three flight deck interfaces for navigation. Background Industry is proposing touch-based solutions to modernize the flight management system. However, research evaluating touchscreen eﬀectiveness for navigation tasks in terms of accuracy and throughput on the flight deck is lacking. Method An experiment was conducted with 14 participants in a flight simulator, aimed at creating Fitts’ law accuracy and throughput models of three different flight deck interfaces used for navigation: the mode control panel, control display unit, and a touch-based navigation display. The former two constitute the conventional interface between the pilot and the flight management system, and the latter represents the industry-proposed solution for the future. Results Results indicate less accurate performance with the touchscreen navigation display compared to the other two interfaces and the throughput was lowest with the mode control panel. The control display unit was better in both accuracy and throughput, which is found to be largely attributed to the tactile and physical nature of the interface. Conclusion Although performance in terms of accuracy and throughput was better with the control display unit, a question remains whether, when used during a more realistic navigation task, performance is still better compared to a touch-based interface. Application This paper complements previous studies in the usage of aircraft touchscreens with new empirical insights into their accuracy and throughput, compared to conventional flight deck interfaces, using Fitts’ law.
DNILMF-LDA: Prediction of lncRNA-Disease Associations by Dual-Network Integrated Logistic Matrix Factorization and Bayesian Optimization

Identifying associations between lncRNAs and diseases can help understand disease-related lncRNAs and facilitate disease diagnosis and treatment. The dual-network integrated logistic matrix factorization (DNILMF) model has been used for drug–target interaction prediction, and good results have been achieved. We firstly applied DNILMF to lncRNA–disease association prediction (DNILMF-LDA). We combined different similarity kernel matrices of lncRNAs and diseases by using nonlinear fusion to extract the most important information in fused matrices. Then, lncRNA–disease association networks and similarity networks were built simultaneously. Finally, the Gaussian process mutual information (GP-MI) algorithm of Bayesian optimization was adopted to optimize the model parameters. The 10-fold cross-validation result showed that the area under receiving operating characteristic (ROC) curve (AUC) value of DNILMF-LDA was 0.9202, and the area under precision-recall (PR) curve (AUPR) was 0.5610. Compared with LRLSLDA, SIMCLDA, BiwalkLDA, and TPGLDA, the AUC value of our method increased by 38.81%, 13.07%, 8.35%, and 6.75%, respectively. The AUPR value of our method increased by 52.66%, 40.05%, 37.01%, and 44.25%. These results indicate that DNILMF-LDA is an effective method for predicting the associations between lncRNAs and diseases.