Miracle-dz/UniFAR-FTUs huggingface dataset:
The self‐concept and image congruence hypothesis

Evaluates the applicability of self‐concept and product image congruity theory within the new motor vehicle market. By utilising competitive product offerings, and by employing the perceptions of actual owners, the paper provides a true market assessment of the applicability of the theory. Respondents were examined using self‐concept and product value constructs and their responses were used to test a number of hypotheses. Among others, the results of analysis of variance indicated that when different brands of motor vehicles were physically similar, owners perceived no difference between their own self‐concepts and the self‐concepts they attributed to owners of competing product brands. This finding differs from previous research conducted on other products and suggests a different orientation by owners of similar motor vehicles to that suggested by self‐concept theory.
Multi-level science mapping with asymmetrical paradigmatic proximity

We propose a series of methods to represent the evolution of a field of science at different levels: namely micro, meso and macro levels. We use a previously introduced asymmetric measure of paradigmatic proximity between terms that enables us to extract structure from a large publications database. We apply our set of methods on a case study from the complex systems community through the mapping of more than 400 complex systems science concepts indexed from a database as large as several millions of journal papers. We will first summarize the main properties of our asymmetric proximity measure. Then we show how salient paradigmatic fields can be embedded into a 2-dimensional visualization into which the terms are plotted according to their relative specificity and generality index. This meso-level helps us producing macroscopic maps of the field of science studied featuring the former paradigmatic fields.
On the Importance of Strategic Alignment in Organizational Culture

Organizational culture plays major role companies' long turn success: Organizational culture can have a major impact 0n corporate strategy and organizational culture is important concept that taken into account to determine company strategies. Meanwhile corporate strategy affected by the established value systems of organization, basic assumption and behaviour norms as well. For this reason, manager must manage organizational culture successfully and provide organizational culture - corporate strategy fit. There are two approaches regarding corporate culture - strategy fit. The first is that accept culture to fit according to strategy. The second is that accept strategy to fit according to culture. Organizational culture is an important part of strategic management. Organizational culture has a strong impact on the success of the company and can make a significant contribution on creation and maintenance of strategic fit.
Uni‐molecular detection and quantification of selected β‐lactam antibiotics with a hybrid α‐hemolysin protein pore

Single‐nanopores have recently been used to electrically detect a wide range of analytes. Similarly, using electrophysiology, we demonstrate how a system comprised of an ion channel formed by α‐hemolysin (α‐HL) and single‐cyclic γ‐cyclodextrin (γ‐CD) molecule permits the detection of, and differentiation between three different antibiotics from the β‐lactam family. Specifically, histograms of the time between the successive binding events, and the residence time distributions of the antibiotic in the γ‐CD molecular adapter vary with the antibiotic type. The results show that the association times of amoxicillin, azlocillin, and ampicillin are τon = 2.1 ± 0.2, 2.2 ± 0.3, and 3.1 ± 0.4 ms, respectively. Interestingly, we found that the residence time of the bulkier and negatively charged azlocillin (τoff = 0.008 ± 0.0005 ms) is much less than that of ampicillin (τoff = 0.07 ± 0.005 ms) and amoxicillin (τoff = 0.1 ± 0.02 ms), even though the γ‐CD–α‐HL complex is anionic selective. The data were also used to estimate the standard free energy of binding between ampicillin to γ‐CDs binding (−12 kcal mol−1). The difference in association times might be due to γ‐CDs‐imposed steric hindrance or an energetically more expensive desolvation step for the antibiotics to gain access to the binding site in the CD. We suggest that this technique may be used to detect other analytes used in pharmaceutical applications. Copyright © 2010 John Wiley & Sons, Ltd.
Evaluation of real-time position accuracy and LNAV/VNAV service availability of GAGAN SBAS (Wide Area Differential GPS) over Indian region

Airports Authority of India (AAI) in collaboration with Indian Space Research Organization (ISRO) has planned to demonstrate Wide Area Differential GPS (WADGPS), over the Indian Flight Information Region for civil aviation application purpose. In GAGAN-TDS (GPS Aided Geo Augmented Navigation-Technology Demonstration System), with a configuration of eight Reference Stations, one Indian Master Control Station, one Indian Land Uplink station with one GEO stationary satellite, accuracy and availability of GAGAN was demonstrated. GAGAN-TDS is leading to a Fully Operational Phase (FOP) Indian SBAS (Space Based Augmentation System). GAGAN will operationally provide Accuracy, Integrity, Continuity, Availability and level of Service.
A Multi-Objective Learning to re-Rank Approach to Optimize Online Marketplaces for Multiple Stakeholders

Multi-objective recommender systems address the difficult task of recommending items that are relevant to multiple, possibly conflicting, criteria. However these systems are most often designed to address the objective of one single stakeholder, typically, in online commerce, the consumers whose input and purchasing decisions ultimately determine the success of the recommendation systems. In this work, we address the multi-objective, multi-stakeholder, recommendation problem involving one or more objective(s) per stakeholder. In addition to the consumer stakeholder, we also consider two other stakeholders; the suppliers who provide the goods and services for sale and the intermediary who is responsible for helping connect consumers to suppliers via its recommendation algorithms. We analyze the multi-objective, multi-stakeholder, problem from the point of view of the online marketplace intermediary whose objective is to maximize its commission through its recommender system. We define a multi-objective problem relating all our three stakeholders which we solve with a novel learning-to-re-rank approach that makes use of a novel regularization function based on the Kendall tau correlation metric and its kernel version; given an initial ranking of item recommendations built for the consumer, we aim to re-rank it such that the new ranking is also optimized for the secondary objectives while staying close to the initial ranking. We evaluate our approach on a real-world dataset of hotel recommendations provided by Expedia where we show the effectiveness of our approach against a business-rules oriented baseline model.
Conceptualising the geographic world: the dimensions of negotiation in crowdsourced cartography

In crowdsourced cartographic projects, mappers coordinate their efforts through online tools to produce digital geospatial artefacts, such as maps and gazetteers, which were once the exclusive territory of professional surveyors and cartographers. In order to produce meaningful and coherent data, contributors need to negotiate a shared conceptualisation that defines the domain concepts, such as road, building, train station, forest and lake, enabling the communication of geographic knowledge. Considering the OpenStreetMap Wiki website as a case study, this article investigates the nature of this negotiation, driven by a small group of mappers in a context of high contribution inequality. Despite the apparent consensus on the conceptualisation, the negotiation keeps unfolding in a tension between alternative representations, which are often incommensurable, i.e., hard to integrate and reconcile. In this study, we identify six complementary dimensions of incommensurability that recur in the negotiation: (1) ontology, (2) cartography, (3) culture and language, (4) lexical definitions, (5) granularity, and (6) semantic overload and duplication.
An object relations perspective on borderline personality

One of the principal formulations of borderline personality disorder is based on object relations theory, a component of psychoanalytic theory. To remain relevant, psychoanalytic formulations must find support from empirical research. After summarizing the object relations understanding of borderline personality, the authors review studies in biological neuroscience, developmental psychology and cognitive science related to the fundamental concepts of object relations theory as it aplies to borderline pathology. This review suggests that these empirical studies support psychoanalytic formulations originally derived from clinical practice and observation.
Cellular and subcellular distribution of the serotonin 5‐HT2A receptor in the central nervous system of adult rat

Light and electron microscope immunocytochemistry with a monoclonal antibody against the N‐terminal domain of the human protein was used to determine the cellular and subcellular localization of serotonin 5‐HT2A receptors in the central nervous system of adult rat. Following immunoperoxidase or silver‐intensified immunogold labeling, neuronal, somatodendritic, and/or axonal immunoreactivity was detected in numerous brain regions, including all those in which ligand binding sites and 5‐HT2A mRNA had previously been reported. The distribution of 5‐HT2A‐immunolabeled soma/dendrites was characterized in cerebral cortex, olfactory system, septum, hippocampal formation, basal ganglia, amygdala, diencephalon, cerebellum, brainstem, and spinal cord. Labeled axons were visible in every myelinated tract known to arise from immunoreactive cell body groups.
Integrated Corporate, Industry and Economy Strategic Performance Measure Analysis -‘Building Matrix’ Model: A Conceptual Framework

Designing and managing strategy for any business mainly depends on the past and present performance of the organisation, and also related to the performance of the industry and the economy. The process of strategic management involves strategic intent, environmental scanning, strategy formulation, strategy implementation and strategy control. The environmental scanning includes the internal analysis external analysis and portfolio analysis. The concept of Company Wide Quality Control (CWQC) in Total Quality Management (TQM) states that the quality of the finished product depends on the quality of duty performed by the each and every department in the organisation. Likewise the performance of an organisation depends on the performance of each and every department or activities or responsible centres of the organisation. This enacts the concept of Company Wide Performance Measure (CWPM). This paper discusses a conceptual model of “building matrix” which relates the departments or activities of an organisation to the basement and consequent floors of a building based on the degree of importance of the departments to the organisation. Then the performance of these departments is measured using Key Performance Indicators (KPI) of the concerned departments using a combination of 5 point scale and colour scale. Likewise the performances of the industry and economy are also measure using the same way. Then the performance of the organisation, its departments and KPIs are analysed in an integrated way. Based on the outcome the strategies may be formulated effectively and efficiently. Key words: strategy, performance measure, key performance indicators, corporate, industry, economy, integrated analysis
Challenges And Strategies Of Supply Chain Management In A Competitive Environment

In a world where companies’ revenues strive not to decrease and market shares are under constant pressure, managers try to find ways to deliver the value demanded by clients. Supply chain seems to be lately the field where they can find space to act and to deliver performance. This paper intends to discover the challenges that the supply chain practitioners must face in order to implement a good supply chain strategy and which strategy will fit best the needs of each company.
Phase II trial of the EGFR tyrosine kinase inhibitor erlotinib for single agent therapy of recurrent Glioblastoma Multiforme: Interim results.

1558 Background: Erlotinib (Tarceva, OSI-774) is an orally available small molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. We have initiated the first phase II trial of erlotinib in single agent therapy of recurrent glioblastoma multiforme (GBM). METHODS Patients with documented recurrent or progressive GBM who have received previous radiation therapy and cytotoxic chemotherapy were eligible for enrollment. No enzyme-inducing anti-epileptic agents were allowed. Patients were treated with 150 mg of erlotinib per day until tumor progression or study withdrawal. Tumor response was determined by MRI. Analysis for EGFR amplification was performed. RESULTS Interim analysis has been performed on a total of 16 of 31 planned patients as of December, 2003. Of these, 4 patients have shown partial responses, 1 showed a partial response of his original tumor but then developed a separate unresponsive focus and 4 have had disease stabilization for greater than 3 months. Seven patients have had tumor progression within 3 months of starting erlotinib. Although a response has been seen in 50% of patients (4 PR + 4 SD), the responses have not been durable; the median time to progression of responders has been 145 days after the start of therapy. Eleven patients have died since the start of the study. The pattern of subsequent treatment failure in responders has suggested a diffuse spread of tumor (e.g. gliomatosis cerebri or leptomeningeal spread). One patient had a tumor-associated cyst in which the steady state OSI-774 level was determined and found to be approximately 40% of that observed in plasma. Approximately one-half of the tumors have had EGFR amplification, but EGFR amplification has not ensured a response to erlotinib and responses have been observed in the absence of amplification. CONCLUSIONS Although these results are preliminary in nature, we are encouraged by the response rate observed to date. The apparent lack of durability of response and the pattern of post-response failure may be due, in part, to reduced drug penetration into the brain, an inadequate dose and/or tumor heterogeneity. [Table: see text].
Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity

Addicts Lose Plasticity What are the biological mechanisms associated with the transition from occasional drug use to addiction? In rats, like in humans, even after a prolonged period of drug intake, only a limited number of animals develop addiction-like behavior despite the amount of drug taken by all subjects being the same. Kasanetz et al. (p. 1709) compared the expression of N-methyl-d-aspartate (NMDA)–dependent long-term depression (NMDA-LTD) in the nucleus accumbens of addicted and nonaddicted rats. Initially, once drug self-administration had been learned and consolidated, but before the appearance of addiction-like behavior, LTD was suppressed in all animals independently of their vulnerability to addiction at a later stage. However, after 2 months, when addiction-like behavior appears, LTD was persistently lost in the addicted animals. In contrast, normal NMDA-LTD reappeared in animals that maintained a controlled drug intake without becoming addicted. Loss of glutamate receptor–dependent synaptic plasticity in the brain is associated with the transition to cocaine addiction. Chronic exposure to drugs of abuse induces countless modifications in brain physiology. However, the neurobiological adaptations specifically associated with the transition to addiction are unknown. Cocaine self-administration rapidly suppresses long-term depression (LTD), an important form of synaptic plasticity in the nucleus accumbens. Using a rat model of addiction, we found that animals that progressively develop the behavioral hallmarks of addiction have permanently impaired LTD, whereas LTD is progressively recovered in nonaddicted rats maintaining a controlled drug intake. By making drug seeking consistently resistant to modulation by environmental contingencies and consequently more and more inflexible, a persistently impaired LTD could mediate the transition to addiction.
Empowerment, attribution and apologising as dimensions of service recovery

The production of most services depends heavily on human involvement which, by definition, implies variability. The difficulty of standardising human behaviour during service delivery at a level expected by customers is exacerbated by the simultaneity of production and consumption. When service failures occur, the presence of customers leaves little scope for corrective action without the customer being aware of the mishap. The difficulty in avoiding visible service failures does not have to result in dissatisfied customers, however. Service firms can go a long way towards turning dissatisfied customers who have had a negative service experience into ones who are likely to remain loyal to the firm. That, however, requires an effective service recovery programme. This study pursued two objectives. The empirical results show that attribution (the firm accepting blame) is, relatively speaking, the dimension most important to customers in their assessment of the service recovery effort, followed by empowerment and apology. Once a service failure has occurred, customers prefer to deal with staff who are empowered to solve their problem quickly and they do not want to hear that someone else is to blame. An apology in person or, alternatively, by telephone is preferable. Surprisingly, pre‐service failure perceptions do not influence the customer’s satisfaction with the recovery effort, suggesting that service recovery is situation‐specific.
Domestic bank intermediation in emerging market economies during the crisis: locally owned versus foreign-owned banks

This paper discusses how the global financial crisis of 2008–09 affected banks operating in emerging market economies (EMEs) and how far it led them to change key aspects of their business models. Aspects of particular interest include: changes in bank funding (maturity and sources of funding); changes in bank lending (in terms of loan maturities; required collateral; types of borrowers; etc); and changes in liquidity management (evidence of a build-up of liquid assets; shortening of lending maturities, etc). The paper also looks at evidence of different response patterns between foreign and local banks in EMEs during the crisis. The analysis is based almost entirely on central bank responses to a BIS questionnaire prepared for the BIS meeting of Deputy Governors of emerging market economies (28–29 January 2010, Basel). The aim is to provide an up-to-date assessment of key changes in domestic bank intermediation in EMEs resulting from the spillovers of the global financial crisis of 2008–09.
A General Approach for the Transient Detection of Slip-Dependent Fault Components Based on the Discrete Wavelet Transform

In this paper, a general methodology based on the application of discrete wavelet transform (DWT) to the diagnosis of the cage motor condition using transient stator currents is exposed. The approach is based on the identification of characteristic patterns introduced by fault components in the wavelet signals obtained from the DWT of transient stator currents. These patterns enable a reliable detection of the corresponding fault as well as a clear interpretation of the physical phenomenon taking place in the machine. The proposed approach is applied to the detection of rotor asymmetries in two alternative ways, i.e., by using the startup current and by using the current during plugging stopping. Mixed eccentricities are also detected by means of the transient-based methodology. This paper shows how the evolution of other non-fault-related components such as the principal slot harmonic (PSH) can be extracted with the proposed technique. A compilation of experimental cases regarding the application of the methodology to the previous cases is presented. Guidelines for the easy application of the methodology by any user are also provided under a didactic perspective.
Intelligent fire risk monitor based on Linked Open Data

Every day the Fire department of the Netherlands work hard to save people’s lives. Therefore, they have been investing in Business Intelligence approaches for several years, to get more information for accident prevention and accident fighting. In this paper Linked Open Data has been used as a business intelligence approach for the creation of dwelling fire risk profiles based on demographic data. During the research a Proof of Concept showed the appliance of Linked Open Data for this purpose. However the data have some quality mismatches, such as: outdated, accuracy issues and not 100% completed. From evaluation sessions it turned out that the outcomes show similarities with a fire incident map and the gut feeling of several firefighters.
Cross-Reactive Protection against Enterohemorrhagic Escherichia coli Infection by Enteropathogenic E. coli in a Mouse Model

ABSTRACT Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) are related attaching and effacing (A/E) pathogens. The genes responsible for the A/E pathology are carried on a chromosomal pathogenicity island termed the locus of enterocyte effacement (LEE). Both pathogens share a high degree of homology in the LEE and additional O islands. EHEC prevalence is much lower in areas where EPEC is endemic. This may be due to the development of antibodies against common EPEC and EHEC antigens. This study investigated the hypothesis that EPEC infections may protect against EHEC infections. We used a mouse model to inoculate BALB/c mice intragastrically, first with EPEC and then with EHEC (E. coli O157:H7). Four control groups received either a nonpathogenic E. coli (NPEC) strain followed by EHEC (NPEC/EHEC), phosphate-buffered saline (PBS) followed by EHEC (PBS/EHEC), EPEC/PBS, or PBS/PBS. Mice were monitored for weight loss and symptoms. EPEC colonized the intestine after challenge, and mice developed serum antibodies to intimin and E. coli secreted protein B (encoded in the LEE). Prechallenge with an EPEC strain had a protective effect after EHEC infection, as only a few mice developed mild symptoms, from which they recovered. These mice had an increase in body weight similar to that in control animals, and tissue morphology exhibited mild intestinal changes and normal renal histology. All mice that were not prechallenged with the EPEC strain developed mild to severe symptoms after EHEC infection, with weight loss as well as intestinal and renal histopathological changes. These data suggest that EPEC may protect against EHEC infection in this mouse model.
Innovation strategies for SMEs and clusters: the challenges of a globalised Europe

In this paper we discuss the challenges for the European SMEs facing increased global competition, and how it is possible to design innovative strategies through the new Regional Competitiveness and Employment Objective. First, the paper offers an assessment of the importance of SMEs in the EU context and particularly in the regions concerned by the new objective. Second, the paper will discuss how globalisation poses a serious thread to this development pattern. Third, we briefly explain why further labour market and product liberalisation policies probably have a limited potential. Fourth, there is a wide empirical literature, and a lot of practical experience, on innovation strategies for SMEs and clusters in Europe. The paper will offer a critical assessment of these findings and will suggest how to make the best use of the limited, but critical, resources available under the new Regional Competitiveness Objective.