Miracle-dz/UniFAR-FTUs huggingface dataset:
Priapism in Patients with Chronic Myeloid Leukemia: Report of Two Cases

Two patients with chronic myeloid leukemia (CML) and priapism are reported. One of these two patients is a 13-year-old boy. As we know leukemia is an uncommon cause of priapism. Sludging of blood in the corpora cavernosum is almost universally accepted as the mechanism of developing painful and persistent erection in these patients. Various forms of treatment have been advocated for the management of this condition and have met with varying degrees of success. Resolution of the priapism in this 13-year-old boy was obtained by using the transglandular cavernosum-spongiosum shunt. However, the priapism in the other patient was completely resoved several days post the treatment with transglandular cavernosum-spongiosum shunt and chemotherapy for the leukemic process. Because of rare cases of CML with priapism documented in the literature, it is impossible to jump a conclusion whether chemotherapy is better than corpora cavernosum-spongiosum shunt or not. Theoretically, we think only if CML is well controlled by chemotherapy, the priapism will be forever resolved; however, corpora cavernosum-spongiosum shunt is still a rapid method to make the priapism relieved.
Polysaccharides-Reinforced Bitumens: Specificities and Universality of Rheological Behavior

The rheological properties of bitumens can be modified by the addition of specific chemical additives. Taking into account the molecular complex aggregation pattern, we hypothesized that macromolecules characterized by long, flexible, and hydrophilic chains can establish soft bridges connecting the different polar aggregates of asphaltenes, strengthening their overall hierarchical supra-structures, and consequently increasing rheological performance at higher temperatures. Here, we propose the use of low cost and high availability polysaccharides as chemical additives to improve the rheological characteristics of a bitumen and to strengthen its thermal resistance. Fourteen different low-cost and high-availability polysaccharides, (flours, gums, and extracts from vegetable products) have been tested. While alghae euchemae have proved to be the most effective additive, corn and 00 flours are the least effective. Attempts to explain their differences have been made considering their chemical interactions with the polar molecules of asphaltenes within the complex framework of their supramolecular hierarchical structures. Through Arrhenius analysis, a correlation between activation energy and preexponential factor has been found, which can be useful for practical purposes, together with an unexpected consistency with the behavior of simple liquids, despite the striking differences in structure. Furthermore, a qualitative model has been suggested. The added value of this work is the focus on polysaccharides constituting low-cost, high availability materials which are sometimes even found as waste in industrial processes, all factors which, together with the environmental issues connected with their use, can be considered for large-scale applications.
Late Testicular Metastasis From Renal Cell Carcinoma

Testicular metastasis from renal cell carcinoma is very rare with 15 cases being identified in the literature. A 61-year old white male was admitted to our clinic with a past history of left kidney nephrectomy for renal cancer in 1993 elsewhere. In 1994 a CTscan showed adrenal metastasis which had been resected. In 1997 2 lung metastases had been detected. The patient was referred to the oncological department. He responded very well to immunotherapy with interferon gamma, GM-CSF and interleukin and is still in stable disease of lung metastases. He now presents with a suspected carcinoma of the left testis. After left inguinal orchiectomy the histological findings showed metastasis from a clear-cell carcinoma. Late intrascrotal metastasis is a rare event in the course of the disease.
Novel Soft-Switching Integrated Boost DC-DC Converter for PV Power System

This paper presents a novel soft-switching boost DC-DC converter, which uses an edge-resonant switch capacitor based on the pulse width modulation PWM technique. These converters have high gain voltage due to coupled inductors, which work as a transformer, while the boost converter works as a resonant inductor. Upon turning on, the studied soft switching circuit works at zero-current soft switching (ZCS), and upon turning off, it works at zero-voltage soft switching (ZVS) while using active semiconductor switches. High efficiency and low losses are obtained while using soft switching and auxiliary edge resonance to get a high step-up voltage ratio. A prototype model is implemented in the Power Electronics Laboratory, Assiut University, Egypt. Seventy-two-panel PV modules of 250 W each were used to simulate and execute the setup to examine the proposed boost converter.
Investigating Drug Properties of Bioactive Compounds of Cymbopogon citratus by Absorption, Distribution, Metabolism, Excretion/Toxicity and Molecular Docking Analysis Against Apolipoprotein N-Acyl Transferase

Delivering a potential drug is a predominant challenge in medicinal chemistry.in this study, bio organic compounds of Cymbopogon citratus was screened by analysing physiochemical properties like solubility, permeability, efficacy, toxicity, and metabolic stability. The optimization of drug potential against virulent protein was calculated by using docking algorithm Autodock 4.2. 3. Structure based ligand docking reveals that the compounds having better inhibition potential against virulent enzymes with insoluble and impermeable activities. The organic compounds of Cymbopogon citratus were screened using Lipinski rule of five and ADME/T prediction for drug likeliness. The structure based ligand docking was done between bioactive compounds of plant and virulent protein that cause diseases. The interaction was visualized using Discovery studio and was studies. The molecular docking of bioactive compounds resulted in better inhibition potential with controlled lipophilicity level, without causing toxicity that harms the natural habitat of humans. The compounds, 1,3,4-trimethyl -3cyclohexene-1-carboxaldehyde exhibit binding energy -4.70 Kcal/mol followed by β-myrcene – 4.35 Kcal/mol and Geraniol -4.35 Kcal/mol. Hence, structure based ligand docking and in silico ADME/T studies revealed that the compounds have better inhibition potential against Apolipoprotein by improving the prediction of drug compounds.
Momentum Trends in the Management of Gastroesophageal Reflux Disease: A Review

Gastroesophageal reflux infection (GERD) is an interminable issue of the upper gastrointestinal tract with worldwide dispersion. The frequency is on the expansion in various parts of the world. In the last 30 to 40 years, researches discoveries have offered ascend to a more strong comprehension of its pathophysiology, clinical presentation, and administration. The suggestion is that the ailment can be unhesitatingly analyzed in view of manifestations alone. Nonerosive reflux disease (NERD) remains the overwhelming type of GERD. Non erosive reflux malady is an exceptionally heterogeneous gathering with huge cover with other utilitarian gastrointestinal issue. There is no best quality level for the analysis of GERD. Esophageal pH observing and intraluminal impedance checking have tossed some light on the heterogeneity of NERD. A considerable extent of GERD patients keep on having manifestations in spite of ideal PPI treatment, and this has required exploration into the improvement of new medications. A few security concerns have been raised about incessant utilization of proton pump inhibitors yet these are yet to be substantiated in controlled studies.
Corporate Social Responsibility Disclosure by State-Owned Enterprises in Indonesia

Purpose: This article aims to investigate the extent to which State-Owned Enterprises (SOEs) in Indonesia disclose their Corporate Social Responsibility (CSR) programs to the general public. Design/Methodology/Approach: Quantitative design is used as the main method in the study. Corporate profiling is used for analyzing SOEs profile and program profiling is used to analyze the profile of CSR programs implemented by SOEs. Findings: The study concludes that, first, SOEs under study disclose their CSR programs to the general public. In terms of indicators it is difficult to conclude that CSR programs disclosed by SOEs signify corporate virtuous citizenship embedding the initial ideas of CSR. Practical implications: Practical implications of the study are two-folds. First, that SOEs in Indonesia, need to strengthen the institutional drivers of CSR, and put pressure on companies to move beyond philanthropy, rhetoric, legitimization, imagery, and public relations to substantive engagement in CSR and genuine attempts at change and development. Second, the implementation of CSR programs by SOEs is judicially liable to public auditing. Originality/Value: The value of this study strengthens arguments which hold that the implementation of CSR, even implemented by SOEs, functions more as corporate survival mechanism rather than for solving social and environmental problems.
Annotations d'entités et de relations sur des résumés d'articles scientifiques pour la détection d'interactions entre aliments et médicaments

Dans cet article, nous presentons le schema d'annotation utilise pour etudier les interactions aliments-medicaments (Food-drug interaction-FDI). Le corpus se compose de 639 resumes d'articles scientifiques issus de Medline. Nous avons defini un schema d'annotation constitue de 21 categories d'entites et de 21 types de relations appliquees sur 9 categories d'entites. Ces schemas ont ete appliques sur des documents rediges en anglais ou en francais, ouvrant la voie a un corpus multilingue annote au moyen des memes categories. Nous presentons egalement quelques experiences d'identification automatique des types de relations. L'adaptation de domaine a partir des interactions medicament-medicament (DDI) permet d'avoir un schema d'annotation des relations selon 4 types. L'extraction automatique de ces relations conduit a une F1-mesure de 0.79 obtenue avec un modele SVM precede d'un processus de selection de descripteurs SFM.
Allelic and Genotypic Distribution in Single Nucleotide Polymorphism (SNP) G.676A > G of Melanocortin-1 Receptor (MC1R) Gene in Indonesian Goat Breeds

The melanocortin-1 receptor (MC1R) gene has been investigated by many studies regarding the pigmentation variation in various species. In order to determine its allelic and genotypic distribution, we sequenced the goat MC1R gene from 78 individuals in ten populations (Gembrong, Senduro, Ettawa Grade, Boerawa, Boerka, Kosta, Samosir, Muara, Boer and Kacang). Direct sequencing method was performed to detect the single nucleotide polymorphisms (SNPs). Three SNPs (g.676A>G, g.748G>T and g.801C>G) were identified in the gene target. The SNP g.676 A > G was used to genotype the investigated animals by using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method with EarI restriction enzyme. In all studied populations, the A allele had the highest frequency (83%) and the G allele had the lowest frequency (17%). The frequency of homozygous AA genotype was the highest (90%) in Kacang goats, while that of heterozygous AG genotype was fixed in Senduro and Boer goats. Analysis of observed heterozygosity, expected heterozygosity, Nei’s (1973) expected heterozygosity, and Shannon index were found to be 0.3425, 0.2858, 0.2838 and 0.4578, respectively.The distribution of MC1R gene in overall breeds confirmed with Hardy-Weinberg equilibrium (P>0.05).
European regulatory framework for the clinical translation of bioprinted scaffolds and tissues

Tissue Engineering and Regenerative medicine, empowered by Biofabrication technologies, hold the premises to provide solutions to unmet clinical needs, such as organ donor shortage or genetic diseases. These huge advancements are determining a changing scenario, with a quite confusing understanding about the steps toward the clinical translation of new researches and products, giving as result an overestimation or an underestimation of the required in vitro and in vivo tests for their validation. The proper definition and classification of the research products can be considered an action toward the refinement of animal experiments. An appropriate classification is crucial because the complications due to the combination of biological and non-biological materials need the application of specific rules. This paper aims at helping the academic and industrial community to clarify the identification and classification of their research products.
Design of high-linearity PVT-robust dynamic amplifier

Design of High-Linearity PVT-Robust Dynamic Amplifier Mantian Zhang, M.S.E. The University of Texas at Austin, 2019 Supervisors: Nan Sun Modern electronic device market demands high power-efficiency, highspeed, and high-resolution analog-to-digital converters (ADC). Amplifiers become increasingly significant in the high-performance ADC design. Dynamic amplifier stands out for its low power consumption feature. However, the process-voltage-temperature (PVT) variation and limited linearity prevent it from wide usage. This thesis presents a high-linearity and PVT-robust dynamic amplifier. It implements the capacitively degenerated linearization (CDL) method to achieve high linearity. Furthermore, it combines a PVTsensing amplifier and a voltage-to-time (V2T) converter as the control timer. Once the foreground calibration is done, the proposed dynamic amplifier will track the PVT variation and provide high-linearity and stable gain. Compared to the conventional CDL dynamic amplifier and the PVT-stabilized
Hydrogen fluence in Genesis collectors: Implications for acceleration of solar wind and for solar metallicity

NASA's Genesis mission was flown to capture samples of the solar wind and return them to the Earth for measurement. The purpose of the mission was to determine the chemical and isotopic composition of the Sun with significantly better precision than known before. Abundance data are now available for noble gases, magnesium, sodium, calcium, potassium, aluminum, chromium, iron, and other elements. Here, we report abundance data for hydrogen in four solar wind regimes collected by the Genesis mission (bulk solar wind, interstream low‐energy wind, coronal hole high‐energy wind, and coronal mass ejections). The mission was not designed to collect hydrogen, and in order to measure it, we had to overcome a variety of technical problems, as described herein. The relative hydrogen fluences among the four regimes should be accurate to better than ±5–6%, and the absolute fluences should be accurate to ±10%. We use the data to investigate elemental fractionations due to the first ionization potential during acceleration of the solar wind. We also use our data, combined with regime data for neon and argon, to estimate the solar neon and argon abundances, elements that cannot be measured spectroscopically in the solar photosphere.
The Use of Clinical Judgment in Differentiating Symptoms of Autism Spectrum Disorder from Those of Other Childhood Conditions: A Delphi Study

More and more, due to long waiting lists at diagnostic clinics and access barriers for certain segments of the population, schools are often the first environment in which children are evaluated for ASD (Sullivan, 2013). And while accurate identification of autism spectrum disorders (ASD) is essential for proper treatment and service provision, large percentages of school and community-based identifications of ASD are overturned when children are re-evaluated with strict clinical criteria (Wiggins et al., 2015). In part, challenges faced in accurately differentiating ASD from other conditions may be contributed to the diagnostic complexities of the condition itself. Clinical expertise is one of, if not the most important factors in accurate diagnostic decision-making during evaluations of ASD. However, there exists little insight into what comprises this expert judgment. Using the Delphi methodology, a panel of clinical and school psychology experts in ASD identification were surveyed until consensus was reached about their use of clinical judgment in differentiating ASD from other conditions. The results of these rounds of questioning were compiled into a decision-making guideline entitled “Beyond Test Results: Developing Clinical Judgment to Differentiate Symptoms of Autism Spectrum Disorders from Those of Other Childhood Conditions. ” Implications of this
Study of effect of specimen thickness, gelatin concentration, normal force and sliding velocity on the stick-slip vibrations of gelatin hydrogel

Abstract Soft solids undergo stick-slip instability which is characterized by the velocity weakening effect where interfacial shear stress decreases with sliding velocity. Soft solids show the hysteresis of energy release rate (G) during the stick and slip phase of a stick-slip cycle. In the present study, the effect of specimen thickness on G is studied by conducting the direct shear sliding experiments on gelatin hydrogel and glass substrate. Interfacial shear stress and corresponding crack lengths obtained during the slide-hold-slide (SHS) experiments are used to determine G analytically. Significance of specimen thickness, normal stress, gelatin concentration and sliding velocity on the hysteresis of G during a stick-slip cycle is discussed in detail. Increase in the specimen thickness, normal stress and gelatin concentration lead to an increase in the hysteresis of G as well as tendency of stick-slip instability. However, increase in the sliding velocity leads to decrease in hysteresis.
Heart Rate Variability: A Historical Perspective

Heart rate variability (HRV) and blood pressure (BP) variability have emerged as multidisciplinary areas of research mainly due to continuous interactions between engineers, physicians and physiologists. Physicists and mathematicians have also contributed concepts from their respective fields. This chapter provides a brief historical perspective of HRV and speculates about its future. Some of the earliest studies on the significance of the beat-to-beat variability of heart rate (HR) were reported by Hon and Lee. They studied fetal HRV during labor and delivery and its relation to fetal health (Hon, 1963, 1965; Hon and Lee, 1963). A seminal article by Hyndman et al. (1971) documented spontaneous 10 s variations in BP and provided a control system model to describe their discovery. Subsequently, Wolf et al. observed that higher RR interval variance was associated with lower in-hospital mortality in patients with acute myocardial infarction (Wolf et al., 1978). Using pharmacological interventions, Akselrod et al. (1981) demonstrated that sympathetic and parasympathetic nervous activities of the autonomic nervous system make frequency-specific contributions to the HR power spectrum. They also reported that the renin-angiotensin system activity strongly modulated the amplitude of the spectral peak located at 0.04 Hz. The continuous development of computer technology and signal processing algorithms (Kay and Marple, 1981; Jenkins and Watts, 1968) accelerated the science of understanding rhythms embedded in the electrocardiogram (ECG) and BP with great vigor and frequency (Kitney and Rompelman, 1980, 1987; Baselli et al., 1986). The discovery that the autonomic nervous system was compromised in clinical conditions such as diabetes (Ewing and Clarke, 1982) and could be studied using power spectral analysis of the HRV signal provided the impetus for further progress in the field. Cardiac diseases such as myocardial infarction (Lombardi et al., 1987) and sudden cardiac death (Myers et al., 1986) were found to be related to reduced HRV. Through an extensive analysis of several hundred Holter tapes from patients who had suffered a myocardial infarction, it became evident that a frequently used time domain statistic, namely the standard deviation of the mean heart CONTENTS
Efectos teratogénicos de insecticidas organofosforados en la etiología de labio y paladar hendido: revisión de literatura

Objective: Evaluate the scientific evidence about the associated relation between the individuals exposure to organophosphates insecticides with the prevalence of non syndromic cleft lip and palate. Material and Methods: The search of scientific articles was held in the data base of PubMed, Science Direct, Academic Google, Medline, Cochrane and Scielo, published between year 2.000 and 2015, and a series of interviews were held to professionals with a Doctor or Master degree In Toxicology, Public Health, Genetics and Biochemistry that were knowledge about this subject. 25 articles of insecticides were reviewed and 5 semi structural interviews. Results: A statistical number of studies stablish an association between the exposure to pesticides with teratogenic effects related with the cleft lip and palate; in vivo experimental studies in animals correlate the exposure the organophosphates insecticide Clorpilifos, with the higher prevalence of cleft palate. Conclusion: some studies found associated relation between the exposure to organophosphates insecticides with increased the incidence of birth abnormalities.
MHealth in Home Care : a designated boundary object-in-use

The aim of this paper is to understand how the role of an mHealth artifact is played out in home care settings. An mHealth artifact, in terms of a mobile app (primarily for tablets) was tested to see how the quality of home care work practice was enhanced and changed. The research question the paper explores is: In what ways is an mHealth artifact re-shaping a home care practice and how does this affect the interaction between the caregivers and the elderly and learning opportunities for the caregivers? This research has an action research approach and it was conducted in a home care organization in a Swedish municipality. The data was collected through semi-structured interviews and observations that were conducted during home visits. Concepts of boundary objects were used to analyze and distinguish interactions and conversations with the designed mHealth artifact. Using the mHealth artifact as a boundary object in the caring situation triggered a caring conversation between the caregivers and the elderly. They grew closer and started having deeper conversations. The shift in responsibility, due to new processes enabled the caregiver to stay for a longer time putting the correct care in centrum. The findings reveal that views of the mHealth artifact as a designated boundary object as well as a boundary object-in-use must co-exist in order to understand the emergent properties situated in a technology mediated caring conversation. The study provides qualitative descriptions from early tests of mHealth applications for home care, an emerging area of concern for both research and practice. It focuses on the interactional and organizational values generated from the actual use of the designed mobile application.
Deep Learning Research Trend Analysis using Text Mining

Since the third artificial intelligence boom was triggered by deep learning, it has been 10 years. It is time to analyze and discuss the research trends of deep learning for the stable development of AI. In this regard, this study systematically analyzes the trends of research on deep learning over the past 10 years. We collected research literature on deep learning and performed LDA based topic modeling analysis. We analyzed trends by topic over 10 years. We have also identified differences among the major research countries, China, the United States, South Korea, and United Kingdom. The results of this study will provide insights into research direction on deep learning in the future, and provide implications for the stable development strategy of deep learning.