Miracle-dz/UniFAR-FTUs huggingface dataset:
Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization*

Background: Macrophage polarization regulates human inflammatory disorders. Results: KLF6 is a novel transcriptional regulator of macrophage polarization. Conclusion: KLF6 regulates macrophage inflammatory gene expression by modulating functions of NF-κB and PPARγ. Significance: Pharmacological agents that modulate KLF6 signaling may allow for therapeutic gain in the treatment of inflammatory disorders. Accumulating evidence supports the importance of macrophage plasticity in a broad spectrum of biological processes operative in health and disease. A major locus of control regulating macrophage polarization is at the transcriptional level, and several major pathways have been elucidated in recent years. In this study, we identify the Kruppel-like transcription factor 6 (KLF6) as a molecular toggle controlling macrophage speciation. KLF6 expression was robustly induced by pro-inflammatory M1 stimuli (e.g. LPS and IFN-γ) and strongly suppressed by M2 stimuli (e.g. IL4 and IL-13) in human and murine macrophages. Gain- and loss-of-function studies suggest that KLF6 is required for optimal LPS-induced pro-inflammatory gene expression, acting cooperatively with NF-κB. Furthermore, KLF6 inhibits anti-inflammatory gene expression by negatively regulating peroxisome proliferator-activated receptor γ expression in macrophages. Collectively, these observations identify KLF6 as a novel transcriptional regulator of macrophage polarization.
Data based identification of short term predictors for stock market trends using heterogeneous model ensembles

We here show the application of heterogeneous ensemble modeling for training short term predictors of trends in stock markets. A sliding window approach is used; model ensembles are iteratively learned and tested on subsequent data points. The goal is to predict trends (positive, neutral, or negative stock changes) for the next day, the next week, and the next month. Several machine learning approaches implemented in HeuristicLab and WEKA have been applied; the models produced using these methods have been combined to heterogeneous model ensembles. We calculate the final estimation for each sample via majority voting, and the relative ratio of a sample's majority vote is used for calculating the confidence in the final estimation; we use a confidence threshold that specifies the minimum confidence level that has to be reached. We show results of empirical tests performed using data of the Spanish stock market recorded from 2003 to 2013.
La mortalité selon le revenu: estimation à partir de données européennes

Nous estimons la relation entre mortalite et revenu pour plusieurs pays europeens dont la France. A partir d’une methode de regression ponderee, l’esperance de vie par classe de revenu est derivee de l’esperance de vie observee pour differents niveaux d’education. Nous distinguons plusieurs cohortes selon le sexe. Les resultats montrent que le differentiel de mortalite selon le revenu est plus important chez les hommes que chez les femmes et qu’il tend a augmenter legerement avec l’âge. De fortes disparites entre pays sont cependant observees avec des inegalites faibles dans les pays nordiques et plus fortes dans les pays de l’Est. La France presente un differentiel de mortalite selon le revenu plutot faible compare aux autres pays de l’echantillon.
Internet-Mediated Dialog with Consumers: A Cross-Industry Multiple-Case Study of Polish Exporters

Abstract Purpose: The paper explores the online dialog of firms and consumers through corporate websites and social networks. The objective is to investigate the state of this dialog, its mechanisms, and outcomes in four export-oriented manufacturing companies that represent a wide spectrum of industries, including FMCG and durable goods, low-priced and expensive products, purchased with high and low involvement. Methodology: A multiple-case study was used as the research method, with data sourced from in-depth interviews, observations, and published documents. Findings: The findings show all managers agree that dialog with consumers is useful, they allocate resources to support it, but its intensity is underwhelming. Dialog effects were reported as positive but only as anecdotal evidence without validation in reliable data, which underscores measuring difficulties. It seems that dialog is the easiest to implement in and brings the most substantial benefits for high-involvement products but, even there, the feedback from consumers is not effectively used for developing product innovations. The major obstacle that restricts rich dialog is not technology but the intensity, speed, and quality of personal contact between employees and consumers. Originality: The empirical material presented here offers original insights that foster a better understanding of online dialog between consumers and manufacturing companies. Our study contributes to the stream of research on value co-creation.
On Contango, Backwardation, and Seasonality in Index Futures

The authors investigate contango and backwardation formations and seasonality traits in Malaysia over 22 years spanning 1995 to 2017. Employing graphical observations and statistical tests, contango and backwardation traits appear through market expectations, seasonality, cost of carry model predictions, and index volatility. Unit root, cointegration, and Granger causality tests are employed to assess the existence of long-term relationships between KLCI (cash/spot index) and FKLI (stock index futures) contracts and the direction of the causality relationship. The results are suggestive of cointegration between the futures price index and the spot index in Malaysia. Moreover, a long-run relationship exists between the two variables—a result of backwardation’s predictive ability to find cash market bottoms. Malaysian markets show backwardation in April to June and August, while December is consistently in contango and exhibits moderately high success in the use of a cost-of-carry model in predicting contango and backwardation.
A Multi-Channel Radiometer with Focal Plane Array Antenna for W-Band Passive Millimeterwave Imaging

Passive millimeter wave imaging can complement security measures in scenarios such as airports or checkpoints, due to the fact that these frequencies penetrate clothes and enable e.g. concealed weapon detection (CWD). Such a radiometric system has to meet several key requirements concerning its thermal and spatial resolution and the image acquisition time. The latter can be reduced significantly by scanning the scene with multiple beams simultaneously. The demonstrator system presented in this paper describes a multi-channel focal plane array (FPA) approach that cuts the overall scanning time down by a factor of four. Dielectric rod antennas are proposed as feed elements in high density arrays. The dielectric wide angle lens of the FPA is focused at a distance of 20 m for stand-off measurements. Besides addressing the design and characterization of both the antenna setup and the radiometric receivers, measurement results are presented to demonstrate the feasibility of the multi-channel concept
A synthesis of empirical research on the validity of Wagner's law

In this paper we provide a synthesis of empirical research in the validity of Wagner's law of the existing literature for the period 1969-2014. Wagner's law attracted the interest of many authors and is still being discussed by policy makers and economists in relation to government spending expansion since it was applied by Adolph Wagner in the 1880s. Additionally, we will present the previous empirical work in this topic. Since the translation of Wagner's 'law' in 1950s, a large number of authors tested various specifications of the law. All these studies found different empirical results: support, no support or mixed results. Conflicting findings in this field are not surprising because of the diverse theoretical predictions and also because countries may be at different stages of economic development; thus, the debate about the relationship between government spending and economic growth remains an unresolved issue.
Simultaneous Monitoring of Argatroban and Its Major Metabolite Using an HPLC Method: Potential Clinical Applications

Argatroban is a peptidomimetic inhibitor of throm bin that is currently undergoing extensive clinical trials as a heparin substitute for thrombotic complications. Argatroban is readily metabolized into a major derivative, M1, that has phar macological characteristics distinct from its parent compound. The currently available clot-based assays measure the cumula tive anticoagulant effect of argatroban and its metabolite(s). Available HPLC methods do not differentiate between argatro ban and M1-metabolite. A modified method was developed to simultaneously quantitate M1-metabolite and argatroban in biological fluids. Initial validation studies for the method in cluded clinical trials of argatroban in patients with heparin- induced thrombocytopenia, (ARG 911 Study) and coronary in terventional procedures (ARG 310 Study). Plasma samples were extracted with acetonitrile and reconstituted in a mobile phase. Calibration curves were prepared by running known standards of argatroban and M1-metabolite in normal human plasma. Ultraviolet detection was made at 320 nm. The reten tion times for argatroban and M1-metabolite peaks were found to be 10.5 ± 0.3 minutes and 3.9 ± 0.1 minutes, respectively. The extraction efficiency was > 95% (r2 = 0.99). In heparin- induced thrombocytopenia patients with major bleeding com plications (n = 30), the relative increase in M1-metabolite compared to argatroban varied widely (two- to eight-fold). The mean concentration of argatroban during the steady infusion period was found to be 0.7 ± 0.35 μg/mL, and for M1- metabolite, it was 5.5 ± 2.8 μg/mL. Proportionate results were not seen when higher dosages of argatroban were administered (coronary angioplasty studies). Argatroban and M1-metabolite levels also compared well with the results in global clotting assays. Owing to the simultaneous quantitation of argatroban and M1-metabolite, this method provides a rapid assessment of the pharmacokinetics and pharmacodynamics of argatroban. The differential quantitation may be useful in the assessment of relative metabolic turnover of argatroban that can be related to the hepatic and renal functions in a given patient.
Neural responses to faces reflect social personality traits

Faces are a developmentally primary and critically important source of social information, and they are processed differently from most other visual percepts. Studies of brain electrophysiology reveal a face-sensitive component, the N170, which is typically enhanced to faces relative to other stimuli. Research in social disabilities suggests that an atypical N170 response in this population may stem from decreased developmental exposure to faces secondary to reduced social interest. Here we examined the relationship between neural responses to faces and social personality characteristics in a normative sample. Participants were pre-screened to identify individuals scoring high on extraversion or introversion. Both groups were presented with upright and inverted face stimuli. An inversion effect, a marker of expertise for faces, was observed in people with high extraversion but not in those with high introversion. These findings suggest that, within typically developing populations, social attitudes are reflected in the neural correlates of face perception.
Credit Market and Economic Growth of Russia: Modeling Mutual Influence

An econometric model of the mutual influence of the credit market and main macroeconomic indicators of the Russian economy is discussed. The obtained results show that the credit market has an obvious positive impact on the economic growth. Applying the model also made it possible to estimate the impact of gross domestic product (GDP) growth on the credit market. The results have shown that GDP is a real driver of the credit market growth and its impact on the credit market considerably exceeds the influence of the existing credit market on the economic growth.
Inhibition of Chemical Cautery–Induced Corneal Neovascularization by Topical Pigment Epithelium–Derived Factor Eyedrops

Purpose: To evaluate the effect of topically administered pigment epithelium-derived factor (PEDF) on experimentally induced corneal neovascularization (NV) in a rat model. Methods: Corneal chemical cauterization was induced in the left eye by using silver nitrate sticks in 160 anesthetized male Sprague-Dawley rats. The rats were randomly assigned to 4 groups with 40 rats each for topical administration of recombinant PEDF, chloramphenicol, chondroitin sulfate, and normal saline (as control). At different intervals (3, 10, 15, and 30 days) of the treatment, rats were euthanized and the corneas removed for immunohistochemistry and Western blot analyses to measure expression levels of PEDF, vascular endothelial growth factor (VEGF), and CD34, an endothelial maker. The right eyes were used as normal control. Results: There were high levels of PEDF expression and low levels of VEGF and CD34 in the normal cornea. VEGF and CD34 levels were significantly induced by chemical cauterization in the groups treated with chloramphenicol, chondroitin sulfate, and normal saline, demonstrating corneal NV. The VEGF and CD34 levels reached a plateau in the cornea on the 10th day after cauterization and remained at high levels thereafter. In contrast, the PEDF treatment prevented the overexpression of VEGF and CD34 induced by the cauterization. Conclusions: PEDF downregulates VEGF expression and inhibits corneal NV induced by chemical cauterization. The results suggested that PEDF has therapeutic potential for corneal neovascular diseases.
Comparison of two series-parallel Hybrid Electric Vehicles focusing on control structures and operation modes

With the aim to significantly reduce fuel consumption and exhaust emission, Hybrid Electric Vehicles (HEVs) are more and more developed. Among the different architecture, series-parallel HEVs have flexible mode operations and high efficiency. There are two basic kinds of series- parallel HEVs, one uses a planetary gear, and another uses two concentric arranged electric machines or one machine with the two rotors. Despite the advantages of seriesparallel hybrid vehicles, the systems and their controls are quite complex. This paper aims at the comparison of their control structures and their operation modes. In order to describe the two systems and organize their control structures, Energetic Macroscopic Representation (EMR) and the inversion-based control are used in this study. The same EMR and its associated control are used to describe these two kinds of series-parallel hybrid vehicles. Some simulation results are showed, discussed and compared.
Hierarchical analysis of anaemia deferral in blood donor candidates: the individual in the population perspective

Background and objectives: Deferral due to anaemia is common in blood donor selection, mainly owing to iron deficiency. This study analysed the prevalence of anaemia, its individual and group‐associated factors in 335 095 blood donor candidates in the Hemominas Foundation, a public blood centre in Minas Gerais State, Brazil.
Australia in an International Emissions Trading (ETS) Scheme: An Economic Evaluation Using the GTAP-E Model

We use the GTAP-E model to analyse two emissions trading scheme (ETS) scenarios under the cap-and-trade system at global level, building on pledges for abatement made by governments after the Copenhagen Accord (2009) and Cancun Agreement (2010). These pledges are used to allocate emissions targets for all the countries in 2020. In the first scenario, an ETS is formulated among Annex 1 countries only. In the second scenario, the ETS is expanded by adding three leading non-Annex 1 emitters – China, India and South Korea. The study shows that the cost of meeting emissions reduction commitments of Australia and other countries can be reduced by engaging in block-level emissions trading. According to the results, a permit price (price per tonne of CO2-e) of US$10.56 emerges with the ETS among Annex 1 countries. This price is reduced to US$6.32 when China, India and South Korea also joined the global ETS. Australia’s real GDP declines by 1.03 and 0.59 percent respectively in two ETS scenarios. Contrary to the widely held view, projections from the GTAP-E model suggest that the ETS has a modest overall economic impact on the Australian economy and globally. Our results confirm that selling permits to the world is not welfare enhancing; rather countries who buy permits improve their welfare.
Relational and directional aspects in the construction of information granules

In this study, we are concerned with a two-objective development of information granules completed on a basis of numeric data. The first goal of this design concerns revealing and representing a structure in a data set. As such, it is oriented toward coping with the underlying relational aspects of the experimental data. The second goal deals with the formation of a mapping between information granules constructed in two spaces (thus, it concentrates on the directional aspect of information granulation). The quality of the mapping is directly affected by the information granules over which it operates, so in essence, we are interested in the granules that not only reflect the data, but also contribute to the performance of such mapping. The optimization of information granules is realized through a collaboration occurring at the level of data and the mapping between the data sets. The operational facet of the problem is cast in the realm of fuzzy clustering. As the standard techniques of fuzzy clustering (including a well-known approach of FCM) are aimed exclusively at the first objective identified above, we augment them in order to accomplish sound mapping properties between the granules. This leads to a generalized version of the FCM (and any other clustering technique for this matter). We propose a generalized version of the objective function that includes an additional collaboration component to make the formed information granules in rapport with the mapping requirements (that comes with a directional component captured by the information granules). The additive form of the objective function with a modifiable component of collaborative activities makes it possible to express a suitable level of collaboration and avoid a phenomenon of potential competition in the case of incompatible structures and the associated mapping. The logic-based type of the mapping (that invokes the use of fuzzy relational equations) comes as a consequence of the logic framework of information granules. A complete optimization method is provided and illustrated with several numeral studies.
Repression of Jasmonate-Dependent Defenses by Shade Involves Differential Regulation of Protein Stability of MYC Transcription Factors and Their JAZ Repressors in Arabidopsis[C][W]

Protein stability of jasmonate (JA)-related MYC transcription factors is regulated by light quality through the corresponding photoreceptors and by CONSTITUTIVE PHOTOMORPHOGENIC1. Shade reduces MYC protein abundance and increases the levels of their JAZ repressors, therefore inhibiting JA-dependent defenses, which underlies the trade-off between shade avoidance and JA-mediated responses. Reduction of the red/far-red (R/FR) light ratio that occurs in dense canopies promotes plant growth to outcompete neighbors but has a repressive effect on jasmonate (JA)–dependent defenses. The molecular mechanism underlying this trade-off is not well understood. We found that the JA-related transcription factors MYC2, MYC3, and MYC4 are short-lived proteins degraded by the proteasome, and stabilized by JA and light, in Arabidopsis thaliana. Dark and CONSTITUTIVE PHOTOMORPHOGENIC1 destabilize MYC2, MYC3, and MYC4, whereas R and blue (B) lights stabilize them through the activation of the corresponding photoreceptors. Consistently, phytochrome B inactivation by monochromatic FR light or shade (FR-enriched light) destabilizes these three proteins and reduces their stabilization by JA. In contrast to MYCs, simulated shade conditions stabilize seven of their 10 JAZ repressors tested and reduce their degradation by JA. MYC2, MYC3, and MYC4 are required for JA-mediated defenses against the necrotrophic pathogen Botrytis cinerea and for the shade-triggered increased susceptibility, indicating that this negative effect of shade on defense is likely mediated by shade-triggered inactivation of MYC2, MYC3, and MYC4. The opposite regulation of protein stability of MYCs and JAZs by FR-enriched light help explain (on the molecular level) the long-standing observation that canopy shade represses JA-mediated defenses, facilitating reallocation of resources from defense to growth.
A Review on the International Handbook of Suicide Prevention: Research, Policy and Practice

1 ناریا ،ناجنسفر ،ناجنسفر یکشزپ مولع هاگشناد ،یکشزپ هدکشناد ،یتسیز رامآ و يژولویمدیپا یشزومآ هورگ داتسا :نفلت 31315123 034 :راگنرود ، 31315123 034 :یکینورتکلا تسپ ، moeygmr2@yahoo.co.uk ، :دیکرا 0000-0003-3070-0166 2 ،راک طیحم تاقیقحت زکرم داتسا ناریا ،ناجنسفر ،ناجنسفر یکشزپ مولع هاگشناد باتک لوا پاچ " شیپ یللملا نیب يامنهار زا يریگ تسرامم ،یشم طخ ،شهوژپ :یشکدوخ " لاس رد 2011 تاراشتنا طسوت يدلایم Wiley-Blackwell روشک رد تمیق اب و ناتسلگنا 110 باتک نیا . دیسر پاچ هب دنوپ راتفگ شش و یس ،شخب هس رد رد و 696 اب ،هحفص ،هدنسیون شش و تصش يراکمه ًاتدمع ياهروشک زا یبرغ ياپورا ،یلامش ياکیرمآ و و نیودت هدش رشتنم . تسا سم ئ تیلو شناد هس هدهع رب باتک شیاریو زا دنم ینعی دنلتاکسا روشک O’Connor, Platt و Gordon هدوب . تسا ناونع اب باتک لوا شخب Suicide Determinants
The Relative Proportion of Preterm Births Complicated by Premature Rupture of Membranes in Multifetal Gestations: A Population-Based Study

Abstract Objective To compare the relative contribution of premature rupture of membranes (PROM) to preterm births in singleton compared with multifetal gestations. Study Design A population-based retrospective cohort study of 291,782 nonanomalous live births in the state of Ohio from January 1, 2006, to December 31, 2007, identified through birth certificate data. Frequency of PROM was compared between singleton and multifetal gestations and then stratified by gestational age at birth. Multivariate regression analysis estimated the risk of PROM by plurality in each gestational age group, accounting for influential risk factors. Results The frequency of PROM increased with increasing plurality of gestation. The relative proportion of preterm birth <37 weeks complicated by PROM increased with gestational plurality 13.2% singletons, 16.8% twins, 20.0% triplets, 19.6% quadruplets, and 100% for higher-order multiples (p < 0.001). The frequency of PROM increased with earlier gestational age at birth, regardless of plurality. The increased risk of PROM in multifetal gestation persisted even after adjustment for influential concomitant risk factors. Conclusion The proportion of preterm birth attributable to PROM increases by plurality of gestation, with its most significant contribution in higher-order multiples and at earliest gestational ages when outcomes are the poorest.
Optimal control of switching times in switched linear systems

Switching time optimization arises in finite-horizon optimal control for switched systems where, given a sequence of continuous dynamics, we minimize a cost function with respect to the switching times. In this paper we propose an efficient method for computing optimal switching times in switched linear systems. We derive simple expressions for the cost function, the gradient and the Hessian which can be computed efficiently online without performing any integration. With the proposed method, the most expensive computations are decomposed into independent scalar exponentials which can be efficiently computed and parallelized. Simulation results show that our method is able to provide fast convergence and handle efficiently a high number switching times.