Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward verifying fossil fuel CO2 emissions with the CMAQ model: Motivation, model description and initial simulation

Motivated by the question of whether and how a state-of-the-art regional chemical transport model (CTM) can facilitate characterization of CO2 spatiotemporal variability and verify CO2 fossil-fuel emissions, we for the first time applied the Community Multiscale Air Quality (CMAQ) model to simulate CO2. This paper presents methods, input data, and initial results for CO2 simulation using CMAQ over the contiguous United States in October 2007. Modeling experiments have been performed to understand the roles of fossil-fuel emissions, biosphere–atmosphere exchange, and meteorology in regulating the spatial distribution of CO2 near the surface over the contiguous United States. Three sets of net ecosystem exchange (NEE) fluxes were used as input to assess the impact of uncertainty of NEE on CO2 concentrations simulated by CMAQ. Observational data from six tall tower sites across the country were used to evaluate model performance. In particular, at the Boulder Atmospheric Observatory (BAO), a tall tower site that receives urban emissions from Denver, CO, the CMAQ model using hourly varying, high-resolution CO2 fossil-fuel emissions from the Vulcan inventory and CarbonTracker optimized NEE reproduced the observed diurnal profile of CO2 reasonably well but with a low bias in the early morning. The spatial distribution of CO2 was found to correlate with NOx, SO2, and CO, because of their similar fossil-fuel emission sources and common transport processes. These initial results from CMAQ demonstrate the potential of using a regional CTM to help interpret CO2 observations and understand CO2 variability in space and time. The ability to simulate a full suite of air pollutants in CMAQ will also facilitate investigations of their use as tracers for CO2 source attribution. This work serves as a proof of concept and the foundation for more comprehensive examinations of CO2 spatiotemporal variability and various uncertainties in the future. Implications: Atmospheric CO2 has long been modeled and studied on continental to global scales to understand the global carbon cycle. This work demonstrates the potential of modeling and studying CO2 variability at fine spatiotemporal scales with CMAQ, which has been applied extensively, to study traditionally regulated air pollutants. The abundant observational records of these air pollutants and successful experience in studying and reducing their emissions may be useful for verifying CO2 emissions. Although there remains much more to further investigate, this work opens up a discussion on whether and how to study CO2 as an air pollutant.
The utility of the state buy-in variable in the Medicare denominator file to identify dually eligible Medicare-Medicaid beneficiaries: a validation study.

OBJECTIVE To compare the adequacy of the state buy-in variable (SBI) in the Medicare denominator file to identify dually eligible patients. DATA SOURCE/STUDY SETTINGS: We used linked Medicare and Medicaid data from Michigan and Ohio for elders diagnosed with incident breast, prostate, or colorectal cancer between 1996 and 2001. STUDY DESIGN Using the Medicaid enrollment file as the "gold standard," we assessed the number of duals from Medicare files in cross-sectional and longitudinal analyses. DATA COLLECTION/EXTRACTION METHODS Data for the study population were linked with Medicare and Medicaid files using patient identifiers. PRINCIPAL FINDINGS Sensitivity was low (74.2 percent, 95 percent confidence interval [CI]: 72.7, 75.6 and 80.8 percent, 79.7, 81.9, in Michigan and Ohio, respectively). PPV was above 95 percent in Michigan and 88.8 percent in Ohio. Both sensitivity and PPV varied between and within the states. Both in Michigan and in Ohio, we observed limited agreement on the length of enrollment in Medicaid between the two data sources. CONCLUSIONS Except to examine disparities by dual status at a very broad level, the SBI variable alone may be inadequate to identify duals. The findings call for improvements in Medicare and Medicaid information management systems and for uniformity in database linking strategies.
Selective growth of human melanoma cells in the brain parenchyma of nude mice

The purpose of this study was to determine whether the growth of human melanoma cells in the brain parenchyma Is selective and represents the growth of unique celts. Six human melanoma cell lines derived from cutaneous lymph node or brain metastases (from six different patients) and melanoma cells isolated from fresh surgical specimens of two primary cutaneous melanomas, two lymph node metastases and two brain metastases (each from a different patient) were injected into the subarachnold space of nude mice. All melanomas produced growths in the leptomeninges, but only melanoma cells Isolated from brain metastases infiltrated into and grew in the brain parenchyma of nude mice. The results from in vitro assays for cell motility or production of gelatlnase activity did not correlate with In vivo growth pattern. However, the In vitro growth of human melanoma cells in the presence of TGF-β2 inversely correlated with potential for brain parenchyma metastasis, I.e. the growth of cells from brain metastases was least inhibited by TGF-β2- These data suggest that melanoma brain parenchyma metastases are produced by unique cells that may be resistant to the antiproliferative effects of TGF-β. 2
In‐series compliance of gastrocnemius muscle in cat step cycle: do spindles signal origin‐to‐insertion length?

1. It has been claimed that stretch in the non‐contractile (extramysial) portion of muscles is substantial, and may produce large discrepancies between the origin‐to‐insertion muscle length and the internal length variations 'seen' by muscle spindle endings. 2. In eight pentobarbitone‐anaesthetized cats, we estimated stretch in the extramysial portion of medial gastrocnemius (MG) muscle with a method similar to the spindle null technique. 3. Length variations of MG previously monitored in a normal step cycle were reproduced with a computer‐controlled length servo. The responses of test MG spindle endings were monitored in dorsal root filaments. Distributed stimulation of ventral root filaments, rate‐modulated by the step‐cycle EMG envelope, served to reproduce step‐cycle forces. The filaments were selected so as to have no fusimotor action on the test spindle. 4. Spindle responses in active cycles were compared with those in passive cycles (stretch, but no distributed stimulation). In some cases concomitant tonic fusimotor stimulation was used to maintain spindle responsiveness throughout the cycle, both in active and passive trials. Generally, small discrepancies in spindle firing were seen. The passive trials were now repeated, with iterative adjustments of the length function, until the response matched the spindle firing profile in the active trial. The spindle 'saw' the same internal length change in the final passive trial as in the active trial. Any difference between the corresponding length profiles was attributed to extramysial displacement. 5. Extramysial displacement estimated in this was was maximal at short mean muscle lengths, reaching about 0.5 mm in a typical step cycle (force rising from 0 to 10 N). At longer mean muscle lengths where muscle force rose from say 2 to 12 N in the cycle, extramysial displacement was in the range 0.2‐0.4 mm. 6. Except at very short lengths, the displacement was probably mainly tendinous. On this assumption, our results suggested that the stiffness of the MG tendinous compartment was force related, and about double that of cat soleus muscle at any given force. Calculations indicated that though the stretch was small, the MG tendon would store and release enough strain energy per cycle to contribute significantly to the E3 phase of the step cycle. The discrepancies in spindle firing were generally quite subtle, so we reject the claim that extramysial stretch poses a serious difficulty for inferences about fusimotion from chronic spindle afferent recordings.
Segmentation of Calcification Regions in Intravascular Ultrasound Images by Adaptive Thresholding

An innovative application of adaptive thresholding is used for calcification regions detection in intravascular ultrasound images. A priori knowledge about the acoustic shadow that usually follows the calcification regions is used as discriminant of other bright regions of the image. Tests were carried out with 20 in vivo coronary artery images obtained from different patients. This proposed algorithm presented specificity of 88% and sensitivity of 84%. A ROC curve, whose AUC was equal to 0.87, was plotted for evaluation of the algorithm performance
Transient exposure to oxygen or nitrate reveals ecophysiology of fermentative and sulfate‐reducing benthic microbial populations

Conflict of interest The authors declare no conflict of interest. Short summary Fermentation coupled to sulfate reduction is a globally important process for the remineralization of organic carbon in marine sediments. The present study uses long-term, replicated continuous culture bioreactors and meta-omics to investigate the ecophysiology of the involved microbial populations at an unprecedented resolution. We reveal complex trophic networks, in which fermenters and sulfate reducers coexist with nitrate- and oxygen respirers, we indicate strategies and niches of the microbial populations, and describe a novel and widespread, yet uncultured fermentative organism. These insights are crucial to understand fermentation coupled to sulfate reduction and relevant to assess microbial dynamics and community-level responses in coastal ecosystems. For the anaerobic remineralization of organic matter in marine sediments, sulfate reduction coupled to fermentation plays a key role. Here, we enriched sulfate-reducing/fermentative communities from intertidal sediments under defined conditions in continuous culture. We transiently exposed the cultures to oxygen or nitrate twice daily and investigated the community response. Chemical measurements, provisional genomes and transcriptomic profiles revealed trophic networks of microbial populations. Sulfate reducers coexisted with facultative nitrate reducers or aerobes enabling the community to adjust to nitrate or oxygen pulses. Exposure to oxygen and nitrate impacted the community structure, but did not suppress fermentation or sulfate reduction as community functions, highlighting their stability under dynamic conditions. The most abundant sulfate reducer in all cultures, related to Desulfotignum balticum, appeared to have coupled acetate oxidation to sulfate reduction. We described a novel representative of the widespread uncultured phylum Candidatus Fermentibacteria (formerly candidate division Hyd24-12). For this strictly anaerobic, obligate fermentative bacterium, we propose the name Ca. “Sabulitectum silens” and identify it as a partner of sulfate reducers in marine sediments. Overall, we provide insights into the metabolic network of fermentative and sulfate-reducing microbial populations, their niches, and adaptations to a dynamic environment.
Do emotional eating urges regulate affect? Concurrent and prospective associations and implications for risk models of binge eating.

OBJECTIVE Emotional eating (EE) reflects an urge to eat in response to emotional rather than physical cues and is a risk factor for the development of binge eating. EE has been conceptualized as an attempt to regulate negative affect (NA), a posited maintenance factor for binge eating. However, no study has examined whether EE urges regulate affect. Further, no studies have examined longitudinal associations between EE urges and positive affect (PA). METHOD We examined within-subject longitudinal associations between affect and EE urges in a community-based sample of female twins (mean age = 17.8 years). Participants (N = 239) completed ratings of affect and EE urges for 45 consecutive days. RESULTS Greater NA was concurrently associated with greater EE urges. Additionally, greater EE urges predicted worse NA for both concurrent and prospective (next-day) analyses. Finally, lower PA was associated with greater EE urges in concurrent analyses, but there were no prospective associations between changes in PA and EE urges. DISCUSSION EE urges do not appear to effectively regulate affect. EE urges in a community-based sample appear to have the same functional relationship with affect as binge eating in clinical samples, further supporting EE as a useful dimensional construct for examining processes related to binge eating.
Systematic Review and Individual Patient Data Meta-Analysis of Sex Differences in Depression and Prognosis in Persons With Myocardial Infarction: A MINDMAPS Study

Objective Using combined individual patient data from prospective studies, we explored sex differences in depression and prognosis post–myocardial infarction (MI) and determined whether disease indices could account for found differences. Methods Individual patient data analysis of 10,175 MI patients who completed diagnostic interviews or depression questionnaires from 16 prospective studies from the MINDMAPS study was conducted. Multilevel logistic and Cox regression models were used to determine sex differences in prevalence of depression and sex-specific effects of depression on subsequent outcomes. Results Combined interview and questionnaire data from observational studies showed that 36% (635/1760) of women and 29% (1575/5526) of men reported elevated levels of depression (age-adjusted odds ratio = 0.68, 95% confidence interval [CI] = 0.60–0.77). The risk for all-cause mortality associated with depression was higher in men (hazard ratio = 1.38, 95% CI = 1.30–1.47) than in women (hazard ratio = 1.22, 95% CI = 1.14–1.31; sex by depression interaction: p < .001). Low left ventricular ejection fraction (LVEF) was associated with higher depression scores in men only (sex by LVEF interaction: B = 0.294, 95% CI = 0.090–0.498), which attenuated the sex difference in the association between depression and prognosis. Conclusions The prevalence of depression post-MI was higher in women than in men, but the association between depression and cardiac prognosis was worse for men. LVEF was associated with depression in men only and accounted for the increased risk of all-cause mortality in depressed men versus women, suggesting that depression in men post-MI may, in part, reflect cardiovascular disease severity.
Satellite cells and myonuclei in young and elderly women and men

The overall aim of this study was to assess the effects of aging on the satellite cell population. Muscle biopsies were taken from the tibialis anterior muscle of healthy, moderately active young (age range, 20–32 years; n = 31) and elderly (age range, 70–83 years; n = 27) women and men with comparable physical activity pattern. Satellite cells and myonuclei were visualized using a monoclonal antibody against neural cell adhesion molecule and counterstained with Mayer's hematoxylin. An average of 211 (range, 192–241) muscle fibers were examined for each individual. Compared with the young women and men, the elderly subjects had a significantly lower (P < 0.011) number of satellite cells per muscle fiber but a significantly higher (P < 0.004) number of myonuclei per muscle fiber. The number of satellite cells relative to the total number of nuclei [satellite cells/(myonuclei + satellite cells)] was significantly lower in the elderly than in the young women and men. These results imply that a reduction in the satellite cell population occurs as a result of increasing age in healthy men and women. Muscle Nerve 29: 120–127, 2004
The Legionella pneumophila phosphatidylinositol‐4 phosphate‐binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication‐permissive vacuole

Legionella pneumophila, the causative agent of Legionnaires' disease, uses the intracellular multiplication/defective organelle trafficking (Icm/Dot) type IV secretion system to establish within amoebae and macrophages an endoplasmic reticulum (ER)‐derived replication‐permissive compartment, the Legionella‐containing vacuole (LCV). The Icm/Dot substrate SidC and its paralogue SdcA anchor to LCVs via phosphatidylinositol‐4 phosphate [PtdIns(4)P]. Here we identify the unique 20 kDa PtdIns(4)P‐binding domain of SidC, which upon heterologous expression in Dictyostelium binds to LCVs and thus is useful as a PtdIns(4)P‐specific probe. LCVs harbouring L. pneumophilaΔsidC‐sdcA mutant bacteria recruit ER and ER‐derived vesicles less efficiently and carry endosomal but not lysosomal markers. The phenotypes are complemented by supplying sidC on a plasmid. L. pneumophilaΔsidC‐sdcA grows at wild‐type rate in calnexin‐negative LCVs, suggesting that communication with the ER is dispensable for establishing a replicative compartment. The amount of SidC and calnexin is directly proportional on isolated LCVs, and in a cell‐free system, the recruitment of calnexin‐positive vesicles to LCVs harbouring ΔsidC‐sdcA mutant bacteria is impaired. Beads coated with purified SidC or its 70 kDa N‐terminal fragment recruit ER vesicles in Dictyostelium and macrophage lysates. Our results establish SidC as an L. pneumophila effector protein, which anchors to PtdIns(4)P on LCVs and recruits ER vesicles to a replication‐permissive vacuole.
Fault-tolerant routing on Complete Josephus Cubes

This paper introduces the Complete Josephus Cube, a fault-tolerant class of the recently proposed Josephus Cube and proposes a cost-effective, fault-tolerant routing strategy for the Complete Josephus Cube. For a Complete Josephus Cube of order r, the routing algorithm can tolerate up to (r+1) encountered component faults in its message path and generates routes that are both deadlock-free and livelock-free. The message is guaranteed to be optimally (respectively, sub-optimally) delivered within a maximum of r (respectively, 2r+1) hops. The message overhead incurred is only a single (r+2)-bit routing vector accompanying the message to be communicated.
Differences in head impulse test results due to analysis techniques.

BACKGROUND Different analysis techniques are used to define vestibulo-ocular reflex (VOR) gain between eye and head angular velocity during the video head impulse test (vHIT). Comparisons would aid selection of gain techniques best related to head impulse characteristics and promote standardisation. OBJECTIVE Compare and contrast known methods of calculating vHIT VOR gain. METHODS We examined lateral canal vHIT responses recorded from 20 patients twice within 13 weeks of acute unilateral peripheral vestibular deficit onset. Ten patients were tested with an ICS Impulse system (GN Otometrics) and 10 with an EyeSeeCam (ESC) system (Interacoustics). Mean gain and variance were computed with area, average sample gain, and regression techniques over specific head angular velocity (HV) and acceleration (HA) intervals. RESULTS Results for the same gain technique were not different between measurement systems. Area and average sample gain yielded equally lower variances than regression techniques. Gains computed over the whole impulse duration were larger than those computed for increasing HV. Gain over decreasing HV was associated with larger variances. Gains computed around peak HV were smaller than those computed around peak HA. The median gain over 50-70 ms was not different from gain around peak HV. However, depending on technique used, the gain over increasing HV was different from gain around peak HA. Conversion equations between gains obtained with standard ICS and ESC methods were computed. For low gains, the conversion was dominated by a constant that needed to be added to ESC gains to equal ICS gains. CONCLUSIONS We recommend manufacturers standardize vHIT gain calculations using 2 techniques: area gain around peak HA and peak HV.
The Application of Stem Cells from Different Tissues to Cartilage Repair

The degeneration of articular cartilage represents an ongoing challenge at the clinical and basic level. Tissue engineering and regenerative medicine using stem/progenitor cells have emerged as valid alternatives to classical reparative techniques. This review offers a brief introduction and overview of the field, highlighting a number of tissue sources for stem/progenitor cell populations. Emphasis is given to recent developments in both clinical and basic sciences. The relative strengths and weaknesses of each tissue type are discussed.
The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas

Upper gastrointestinal adenocarcinomas (UGCs) respond poorly to current chemotherapeutic regimes. The authors and others have previously reported frequent Aurora kinase A (AURKA) gene amplification and mRNA and protein overexpression in UGCs. The objective of the current study was to determine the therapeutic potential of alisertib (MLN8237) alone and in combination with docetaxel in UGCs.
Risk Diffusion Modeling and Vulnerability Quantification on Japanese Human Mobility Network from Complex Network Analysis Point of View

The human mobility networks are vital infrastructure in recent social systems. Many efforts have been made to keep the healthy human mobility flows to maintain sustainable development of recent well-connected society. However, the inter-connectivity sometimes raises unintended diffusion and amplification of the intrinsic risks, which is difficult to forecast because of the complexity of the underlying networks. Therefore, it is believed that modeling and simulation of the risk diffusion in the human mobility networks are suggestive and meaningful. Also, recent improvement of usability of individual-level human mobility data and capabilities of high-performance computing technologies enable us to employ the data-driven approaches. In this paper, the risk diffusion dynamics is modeled based on the SIS epidemic model and the vulnerability index is defined to quantify the node-level easiness of suffering risks. We also conduct the link removal test to find the better risk mitigation methods.
Mon2, a Relative of Large Arf Exchange Factors, Recruits Dop1 to the Golgi Apparatus*

The protein Mon2 is distantly related to the guanine nucleotide exchange factors (GEFs) that activate Arf1 on Golgi membranes. However, unlike these “large” Arf GEFs, Mon2 lacks the Sec7 domain that catalyzes nucleotide exchange on Arf1. Here we report that yeast Mon2 shares extensive homology with the noncatalytic parts of both the BIG and Golgi brefeldin A resistance factor subfamilies of Arf GEFs and is located to the trans-Golgi. Moreover, we find that Mon2 forms a complex with Dop1, a large cytoplasmic protein conserved in evolution from humans to protozoa. Deletion of Mon2 results in mislocalization of Dop1 from the Golgi and defects in cycling between endosomes and the Golgi. However, unlike Mon2, Dop1 is essential for yeast viability. A conditional allele of Dop1 shows that loss of Dop1 activity not only affects endosome to Golgi transport but also causes a severe perturbation of the organization of the endoplasmic reticulum. Thus, it appears that Dop1 plays a widespread role in membrane organization, and Mon2 acts as a scaffold to recruit the Golgi-localized pool of Dop1.
Toward Better Understanding and Use of Business Intelligence in Organizations

ABSTRACT This article provides valuable information on the chances and the possibilities of Business Intelligence applying in organizations. Three theories—the Resource-Based View, Maturity Models, and Critical Success Factors—were used to investigate Business Intelligence issues. They provided a comprehensive view on Business Intelligence. Using a semi-structured interview method, the results from 20 organizations applying Business Intelligence are presented. Finally, based on the analysis of the literature and on the qualitative surveys, conclusions for future research in Business Intelligence are provided.