Miracle-dz/UniFAR-FTUs huggingface dataset:
Differentiation of Allelic Frequencies at Quantitative Trait Loci Affecting Locally Adaptive Traits

σ 2 t 5 (1 1 Fst)σ 0 , Direct comparisons of population differentiation obwhere σ w, σ b, and σ t are the within-population, beserved in neutral loci with that seen in quantitative traits tween-population, and total genetic variances in the trait, have revealed discordant patterns, most commonly that respectively, and σ 0 is the genetic variance for the trait quantitative traits are more differentiated than single expected if the populations formed a single panmictic neutral loci. For example, body size has a greater prounit (Wright 1951, 1952; Lande 1992). Thus an estimate portion of genetic variation attributable to amongof population differentiation for quantitative traits population differences than do presumed neutral allo(termed Qst by Spitze 1993) can be computed as zymes in both Drosophila buzzatii (Prout and Barker
The Role of Tourism and Hotels Faculties in Developing Soft Skills for Undergraduate Students in Egypt

The role of tourism and hotels faculties is not only focusing on academic knowledge and hard skills for students, but also including the development of soft skills in order to improve the quality of graduates and employability. Soft skills development is intended to enable and enhance personal development, participation in learning, and success in employment paths. Soft skills are to be considered as complementary to technical skills (hard skills) and knowledge that students acquire during their university study. This study aims to exploring the role of tourism and hotels faculties in Egypt in developing soft skills for undergraduate students. A survey tool is designed covering four main study dimensions including: Perception of Soft Skills Importance, Faculty’s Encouragement, Types of Soft Skills, and Practiced Methods for Soft Skills Development. A total of 388 completes are collected from students (255 completes) and faculty staff members (93 completes). The study found that the most serious obstacles for developing students’ soft skill were: lack of clear policies and programs, the absence of interest of students in developing their soft skills, some staff members give more attention to basic technical skills (hard skills) than soft skills. This study presented few recommendations that can help the faculties and staff members to better develop soft skills for students including: diversification of soft skills using a variety of methods, offering clear policies and programs for soft skills development such as training programs, seminars and workshops, embodying soft skills in curriculums, and increasing the level of students' activities encouraging them to participate in. Moreover, staff members should give attention to both basic technical skills (hard skills) and soft skills.
Fine‐scale genetic structure in a free‐living ungulate population

The fine‐scale genetic structure of wild animal populations has rarely been analysed, yet is potentially important as a confounding factor in quantitative genetic and allelic association studies, as well as having implications for population dynamics, inbreeding and kin selection. In this study, we examined the extent to which the three spatial subunits, or hefts, of the Village Bay population of Soay sheep (Ovis aries) on St Kilda, Scotland, are genetically structured using data from 20 microsatellite and protein loci. Allele frequencies differed significantly among three hefts in all the study years we considered (1987–2000 inclusive). Small but significantly positive FST and negative FIS values were observed in most years, indicating that the hefts are genetically differentiated, and that within each heft there is more observed heterozygosity than would be expected if each were an isolated breeding population. Males showed less fidelity to their natal heft, and as a consequence higher levels of relatedness within hefts were observed among females than among males. There was a significant negative relationship between geographical proximity and relatedness in pairwise comparisons involving females, and on average pairs of females located within 50 m of each other were related at the equivalent level of second cousins. Structure is therefore largely driven by incomplete postnatal dispersal by females. Mating appears to be random with respect to the spatial‐genetic substructure of the hefts, and therefore genetic structure does not contribute to the overall rate of inbreeding in the population. However, genetic substructure can lead to allelic associations and generate environmental effects within lineages that have the potential to confound heritability analyses and allelic association studies.
Perceived Influence of Flood Disaster on the Management of Secondary Schools in Makurdi Education Zone of Benue State, Nigeria

The study investigated the influence of flood disaster on the management of secondary schools in Makurdi Education Zone of Benue State. Two research questions and two research hypotheses guided the study. Descriptive survey design was adopted for the study. The population comprised 1089 teachers from 149 secondary schools. A total of 220 teachers from 20 secondary schools was selected using simple random sampling technique. Flood Disaster and School Management Questionnaire (FDSMQ) was used for data collection. The data collected were analysed using mean and standard deviation to answer the research questions and chi-square to test the hypotheses at 0.05 level of significance. The findings revealed that flood disaster significantly influences school facilities and school attendance in secondary schools in Makurdi Education Zone of Benue State. Based on the findings, it was recommended among others that unconventional schools should be organized in IDP (Internally Displaced persons) camps to give displaced students the opportunity of schooling again.
Craft brewing – is it really about the sensory revolution?

The sudden craft breweries expansion currently occurring in Europe, and by that also in Croatia, has been a true conundrum. The question is why craft breweries currently undergo such intense propagation. The answers to this is not simple and has to be monitored from a few different angles: what are today’s consumer’s preferences? Why this sudden need to drink posh beer? Health wise – is it healthier to drink craft beer than industrial? The fact is that craft breweries offer beer with a story. The popularity of health benefits of moderate beer consumption, different reports in popular papers and magazines on polyphenolic and other anti-oxidative compounds that aid catching free radicals and reduce the damage they cause, contribute to the shift from industrial plane lager beer craft beer. In the eye of the scientific storm-genetic manipulation with yeast strains, and barley cultivars, water treatments, automatization, people choose simple procedures and raw materials that give them a feeling of uniqueness. This paper contributes to the knowledge of why craft breweries are taking on more and more popularity and why are consumers attracted to such products.
Are Key Market Players in Currency Derivatives Markets Affected by Financial Conditions?

This study investigates if the biggest players in major foreign currencies futures markets are affected by current and previous financial conditions. Using root mean squared errors (RMSE), normalized RMSE, and Nash-Sutcliffe efficiency, this study compares the impact of current, 1 and 2 week lags of financial conditions onto foreign currency futures players’ net positions. The financial conditions indices used are UFCI, STLFSI, NFCI and ANFCI with weekly data set from January 2007 till December 2018. The US dollar index futures is included as a benchmark, since the financial conditions are based on US data and the most actively traded foreign currencies are paired against the USD. While RMSE and NRMSE gave mixed results into how current, 1 week and 2 weeks lagged Financial Conditions Indices (FCIs) values are related to speculators and hedgers’ net positions, lagged NFCI captured the highest correlation with both players’ net positions in Japanese Yen. 95% prediction levels encompassed the actual net positions held, including the financial crisis of 2008-2009. Forecasts were lower (higher) for hedgers (speculators) than actual net positions held during the same period. Comparatively, in the period 2016-2017, hedgers (speculators) net positions forecasts were higher (lower) than actual positions. The latter could be explained by FCIs not being affected during this period’s event, compared to net positions. While net positions data were stationary, excess kurtosis was present pointing to non-normal and autocorrelated series. This suggests the need to look into other components like non-reportable long or short positions in future analysis.
Méta-Étiqueteur Adaptatif : vers une utilisation pragmatique des ressources linguistiques

Le traitement automatique du langage requiert des corpus textuels de plus en plusvolumineux, entre autres pour les etiqueteurs morpho-syntaxiques. Ces processus detraitement ne sont pas exempts d'erreurs. Dans l'optique d'ameliorer cet etiquetage de corpusheterogenes (composes de textes tout-venant), une approche adaptative au type de texteutilisant les ressources produites par une campagne d'evaluation sera proposee. Les resultatsd'une premiere validation seront presentes sur les donnees MULTITAG. Les faits suivantssont constates : les textes ne sont pas homogenes en terme de distribution de parties dudiscours, les classifications a priori ne fournissent pas une homogeneite en terme deperformance et un meme texte peut produire des variations positives pour un systeme etnegatives pour un autre. De plus, il existe une relation entre la typologie de textes obtenue defacon non supervisee sur le jeu de caracteres et les variations de performance.
Cr Induced Magnetization in Zinc-Blende ZnO Based Diluted Magnetic Semiconductors

The capability of exploiting the electronic charge and spin properties simultaneously in a single material has made diluted magnetic semiconductors (DMS) remarkable in the field of spintronics. We report the designing of DMS based on zinc-blend ZnO doped with Cr impurity. The full potential linearized augmented plane wave plus local orbital FP-L(APW+lo) method in density functional theory (DFT) has been adapted to carry out these investigations. For treatment of exchange and correlation energy, generalized gradient approximations have been used. Introducing Cr atoms in the matrix of ZnO has induced strong magnetic moment with ferromagnetic ordering at stable ground state. Cr:ZnO was found to favor the short range magnetic interaction that reflect tendency of Cr clustering. The electronic structure of ZnO is strongly influenced in the presence of Cr impurity atoms where impurity bands appear in the band gap. Keywords—ZnO, Density functional theory, Diluted magnetic semiconductors, Ferromagnetic materials, FP-L(APW+lo).
6th International Workshop on Clinical Pharmacology of HIV Therapy

The 6th International Workshop on Clinical Pharmacology of HIV Therapy convened at the Fairmont Le Château Frontenac in Québec, Canada on April 28 – 30, 2005. More than 170 participants registered for this workshop, demonstrating the continued interest in exploring and understanding the complexities of antiretroviral pharmacology. The purpose of this meeting was to present and discuss research related to antiretroviral pharmacokinetics, pharmacodynamics, drug interactions, therapeutic drug monitoring and the assays necessary for measuring antiretroviral concentrations. This article highlights some of the 22 oral and 98 poster presentations that were presentated at this meeting.
Compresión de imágenes usando wavelets

Las wavelets y el analisis de multirresolucion constituyen una potente herramienta para afrontar problemas fundamentales en el tratamiento de senales. Entre ellos se encuentran la reduccion del ruido, la compresion de senales (de mucha importancia tanto en la transmision de grandes cantidades de datos como en su almacenamiento) o la deteccion de determinados patrones o irregularidades locales en ciertos tipos de senales (electrocardiogramas, huellas digitales, vibraciones de motores, defectos de soldadura entre placas de acero, entre otras) (ver, p.e., [1], [7], [9], [11], [12], [18], [20], [23], [24], [30], [42], [47]). Esta moderna teoria ha experimentado un gran desarrollo en las dos ultimas decadas mostrandose muy eficiente donde otras tecnicas, como por ejemplo, la transformada rapida de Fourier no resultaban satisfactorias.
Hedging against uncertain supply and demand using options in a single period framework

This paper considers the impact of an option contract for a retailer/buyer and a manufacturer/supplier, within a single-period newsvendor framework, with a random supply and a random demand that incorporates hedging possibilities through call and put options. We consider two cases. In Case 1, the retailer hedges against the uncertain supply and the uncertain demand and the manufacturer does not hedge. In Case 2, the manufacturer hedges against the uncertain yield and the retailer does not hedge. We particularly focus on deriving (a) the optimal price and order quantity decisions of the retailer, in terms of both the committed order quantity and the number of option contracts; (b) the optimal pricing decision of the manufacturer with full information about retailer's decision parameters and hence its optimal decisions. Here the demand consists of a mean demand component that is price dependent and an additive error component which is uniformly distributed.
Smoking, type of alcoholic beverage and squamous‐cell oesophageal cancer in northern Italy

Between 1992 and 1997, we conducted a case‐control study of oesophageal cancer in 3 areas of northern Italy. Cases were 275 men, ages 39–77 years (median age 60), with a first incident squamous‐cell carcinoma of the oesophagus. Controls were 593 men, ages 36–77 years (median age 60) admitted for acute illnesses, unrelated to tobacco and alcohol, to major hospitals of the areas under surveillance. Number of daily cigarettes was strongly associated with risk [odds ratio (OR) for ≥25 cigarettes/day = 7.0)]. Long‐duration smoking showed particularly elevated ORs (OR = 6.4 for ≥35 years), and excess risk declined after smoking cessation (OR = 1.5 after ≥10 years). Oesophageal cancer risk steeply rose with increasing level of alcohol consumption. ORs were 6.2 for 35–55 drinks and 24.5 for 84 drinks or more per week. No trend in risk emerged for duration of alcohol drinking or age at start of drinking. The risk in the highest joint level of alcohol drinking and current smoking was increased 130 folds (i.e., compatible with a multiplicative model). Excess risk in drinkers chiefly derived from wine. In conclusion, alcohol drinking and cigarette smoking were both important, but the roles of dose and duration of exposure differed. The association with alcohol was stronger than the one with smoking by exposure intensity, but apparently unaffected by duration or other temporal variables. Int. J. Cancer 86:144–149, 2000. © 2000 Wiley‐Liss, Inc.
Air pollution and the inflammatory bowel diseases

The inflammatory bowel diseases (IBDs) predominantly emerged in the industrialized world during the latter part of the 19th century. Early in the 20th century the incidence of ulcerative colitis (UC) was higher than Crohn’s disease (CD) in developed nations. While the incidence rates of UC stabilized in developed countries, the incidence of CD began to steadily rise in industrialized nations in the mid portion of the century. These trends were observed in Europe and North America. In developing nations IBD was a rare occurrence; however, as these nations became more industrialized the incidence of UC increased. Initially the incidence of CD in developing nations remained low, although eventually the occurrence of CD has approximated that of UC. Epidemiological studies that have explored the incidence of IBD have consistently demonstrated that IBD emerged in the developed world first and that IBD occurs more predominantly in urban versus rural regions. However, environmental risk factors associated with industrialization and urban predominance have been incompletely investigated. In this issue of Inflammatory Bowel Disease an article evaluates the association between air pollution exposure and increased hospitalizations for CD and UC. Ananthakrishnan et al correlated IBD hospitalization rates in 72 counties of Wisconsin with the annual mean total emissions concentrations for ambient air pollutants monitored by the US Environmental Protection Agency. In this ecological analysis the authors reported a modest statistically significant correlation between counties with greater air pollution emissions and those with higher rates of IBD hospitalizations. Although limitation of the study design precludes a definitive conclusion, this article is provocative because the findings suggest that a link may exist between the air we breathe and exacerbation of IBD. The purpose of this editorial is to explore whether epidemiological and biological evidence supports the notion of this relationship and to highlight the limitations of air pollution and health research.
Prenatal Factors and Adult Mental and Physical Health

Objective: To review research on prenatal influences on adult mental and physical health and draw implications for future directions in psychiatric research. Method: Schizophrenia is selected as an example from mental health and cardiovascular disease as an example from physical health. For each of these disorders, empirical findings on prenatal influences are reviewed, and the methods used to demonstrate them are critiqued. Results: Research on prenatal antecedents of these conditions has proceeded in parallel: intriguing findings have related fetal growth restriction or fetal insult to adult health; similar types of causal pathways have been proposed to explain the relationships; and research has been plagued by similar limitations, including lack of precise prenatal exposure data and difficulty of controlling confounding. The prevailing view of disease causation, which is not well-suited to investigation of prenatal antecedents, impedes research in both fields. Yet, there has been little interchange between researchers in the 2 fields. Conclusions: We propose a causal paradigm that could serve as a guide for future investigations on the prenatal antecedents of adult health and promote interchange between research on mental and physical health. The paradigm reflects current thinking in epidemiology by encompassing not only risk factors as traditionally conceived but also causal chains over time and causal influences at multiple levels of organization. Implications for the design of new research are illustrated with reference to an ongoing study.
DYNAMICS OF ESCHERICHIA COLI POPULATION EXPRESSING HETEROLOGOUS PROTEINS

Expression of heterologous proteins in Escherichia coli is an important and highly used system for obtaining large quantities of recombinant proteins for a wide range of applications in biotechnologies, medicine etc. However, the ability for delivering high quantities of recombinant proteins at desired quality and the cost effectiveness of the process is under serious scrutiny. Most improvements on bioprocesses for recombinant proteins production are focused on downstream processing, like primary recovery and purification. The present work relies on monitoring the bacterial population development and dynamics in the bioreactor, and presents the premises for modelling and optimization.
Using Ge-Doped La-Oxynitride as Interfacial Passivation Layer for GaAs Metal-Oxide-Semiconductor Capacitors

The GaAs MOS capacitors using ZrON as high-k gate dielectric with LaGeON or LaON as an interfacial passivation layer (IPL) are fabricated and their electrical and interfacial properties are investigated. Compared to their counterpart without IPL, introducing LaGeON or LaON as IPL results in a large improvement of interface quality and electrical properties of the GaAs MOS devices, for example, improved capacitance-voltage behavior, reduced interface-state density and gate leakage current, and enhanced device reliability. Moreover, because of Ge incorporation, the LaGeON IPL becomes more stable and can more efficiently block the Ga/As out-diffusion and O in-diffusion to reduce the defect-related Ga/As-O and As-As bonds at the GaAs surface, thus exhibiting the best interface quality and electrical properties, and high device reliability.
Crawling Cells Can Close Wounds without Purse

When a gash or gouge is made in a confluent layer of epithelial cells, the cells move to fill in the ‘‘wound. ’’ In some cases, such as in wounded embryonic chick wing buds, the movement of the cells is driven by cortical actin contraction (i.e., a purse string mechanism). In adult tissue, though, cells apparently crawl to close wounds. At the single cell level, this crawling is driven by the dynamics of the cell’s actin cytoskeleton, which is regulated by a complex biochemical network, and cell signaling has been proposed to play a significant role in directing cells to move into the denuded area. However, wounds made in monolayers of Madin-Darby canine kidney (MDCK) cells still close even when a row of cells is deactivated at the periphery of the wound, and recent experiments show complex, highly-correlated cellular motions that extend tens of cell lengths away from the boundary. These experiments suggest a dominant role for mechanics in wound healing. Here we present a biophysical description of the collective migration of epithelial cells during wound healing based on the basic motility of single cells and cell-cell interactions. This model quantitatively captures the dynamics of wound closure and reproduces the complex cellular flows that are observed. These results suggest that wound healing is predominantly a mechanical process that is modified, but not produced, by cell-cell signaling. Citation: Lee P, Wolgemuth CW (2011) Crawling Cells Can Close Wounds without Purse Strings or Signaling. PLoS Comput Biol 7(3): e1002007. doi:10.1371/ journal.pcbi. 1002007 Editor: Andrew D. McCulloch, University of California, San Diego, United States of America Received September 27, 2010; Accepted December 23, 2010; Published March 10, 2011 Copyright: 2011 Lee, Wolgemuth. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This research was supported by the NSF (DMS 0920279). The funders had no role in study design, data collection and analysis, decision to publish, or prepartation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: cwolgemuth@uchc.edu
The Role of Person-Organization Value Fit in Employees’ Experience of Meaningful Work, Use of Strengths and Work Engagement

Research in the field of management, in particular human resource management (HRM), increasingly highlights the importance of person-organization value fit. Adding to this growing body of research, this study examines the complex relation between person-organization value fit, employees’ perceptions of work, employees’ behavior at work and their well-being. More precisely, we hypothesize that person-organization value fit has a positive relationship with employees’ work engagement (well-being) via both the experience of meaningful work (perceptions) and the use of their strengths at work (behavior). We conducted a structural equation modeling on a sample of 1050 employees working in various occupations, organizations, and industries in The Netherlands. The results provided support for the proposed model, indicating an important role for person-organization value fit in the on-going pursuit of meaningful work and well-being at work. The insights provided in this study do not only contribute theoretically; they are also helpful for managers and HR professionals in optimizing human resource management policies and practices.