Miracle-dz/UniFAR-FTUs huggingface dataset:
A High-level User-oriented Framework for Database Evolution

Databases are well suited to the task of describing and organizing research datasets, however, the difficulties of using database management systems effectively have resulted in their limited usage among domain scientists. Scientists operate in an environment that is changing steadily with new experimental protocols, instruments, and discoveries that impact what datasets they generate and how they describe and organize them. In order to manage datasets for a scientific application, scientists need to routinely revise their database schemas to reflect these changes. Unfortunately, evolving a database is one of the well-known and most difficult aspects of database usage. The conventional data definition and manipulation languages offer relatively low-level programming abstractions to perform complex database evolution tasks, and therefore require specialized technical skills not possessed by most domain scientists. A simplified means of expressing database evolution operations can reduce the effort of keeping the scientific database in sync with changing requirements. This paper presents a high-level, user-oriented, schema evolution framework with an algebra of specialized schema modification operators. The approach allows introduction of novel operators as motivated by new requirements and is amenable to well established optimization techniques for efficient planning and execution. We present the framework and its implementation, and we demonstrate its utility in an exemplar use case and performance evaluation.
Clinical guidance for the use of trazodone in major depressive disorder and concomitant conditions: pharmacology and clinical practice.

AIM To provide a review of the clinically relevant evidence pertaining to the use of trazodone in major depressive disorder. METHODS Medline and Cochrane Library searches were searched using the keywords 'trazodone' AND 'depression', to identify the most relevant literature pertinent to the pharmacological properties of trazodone and its use in clinical practice. Articles that were selected included basic pharmacology papers, clinical trials, clinical practice guidelines, and reviews. Related references were cross checked. European and United States prescribing information was reviewed as well. An effort was made to give weight to the information that was most relevant for daily clinical practice. RESULTS Trazodone is an antidepressant with a mechanism of action that remains innovative and with a favorable profile for the treatment of depression. The appropriate antidepressant doses are usually 150-300 mg/day and are often higher than the doses that are used when trazodone is prescribed to augment the antidepressant effect of another medication, for instance when trazodone is prescribed to address insomnia in a patient treated with an SSRI. Trazodone is usually well tolerated and has a low risk of anticholinergic side effects, weight gain and sexual side effects. DISCUSSION Trazodone is an established medication that is efficacious for the treatment of a broad array of depressive symptoms, including symptoms that are less likely to respond to other antidepressants (e.g. SSRI), such as insomnia. As an antidepressant, trazodone has proven as efficacious as the tricyclic and second-generation antidepressants and is tolerated relatively well. Trazodone may be helpful for patients with major depression and comorbid insomnia, anxiety or psychomotor agitation. CONCLUSIONS Trazodone is efficacious antidepressants with a relatively low risks of side effects such as weight gain, sexual or anticholinergic effects (such as constipation, urinary retention, dry mouth). In addition to being able to control a wide range of depressive symptoms, trazodone may improve sleep and be particularly helpful for patients whose symptoms of depression include insomnia.
Perindopril inhibits myocardial apoptosis in mice with acute myocardial infarction through TLR4/NF-κB pathway.

OBJECTIVE To explore the anti-apoptotic effect of perindopril on myocardial cells in mice with acute myocardial infarction (AMI). MATERIALS AND METHODS A total of 48 mice were randomly divided into 4 groups before intervention, namely sham operation group (Sham group, n=12), AMI group (n=12), 1.5 mg/kg perindopril treatment group (Perindopril group, n=12), and 1.5 mg/kg perindopril treatment and Toll-like receptor-4 (TLR4) knockout group (TLR4-/-Perindopril group, n=12). Mice in the control group and AMI group were gavaged with normal saline, and those in the Perindopril group and TLR4-/-Perindopril group were gavaged with perindopril for 7 d. On the 4th day after drug administration, mice in the AMI group, Perindopril group and TLR4-/-Perindopril group were subjected to the ligation of the anterior descending coronary artery to induce AMI, and those in the Sham group underwent the same operation, but had a loose knot at the anterior descending coronary artery. At 24 h after the above operation, color echocardiography was performed on mice to observe changes in cardiac function. Then, the mice were sacrificed. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP)-biotin nick end labeling (TUNEL) assay was carried out to determine myocardial apoptosis. Immunohistochemistry and Western blotting technique were employed to detect the protein expression levels of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), TLR4 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p50 in infarction zones. The messenger ribonucleic acid (mRNA) expression levels of TLR4 and NF-κB p50 in infarction zones were measured via Reverse Transcription-Polymerase Chain Reaction (RT-PCR). RESULTS Perindopril could significantly reduce the number of apoptotic myocardial cells after AMI. Mouse echocardiography showed that ejection fraction (EF), left ventricular fractional shortening (FS), left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) of AMI mice in the Perindopril groups were markedly superior to those in the AMI group. AMI mice in the Perindopril group had decreased expression levels of Bax protein and TLR4 and NF-κB p50 mRNA and protein, as well as the Bax/Bcl-2 ratio. Knockout of TLR4 attenuated the effect of perindopril in alleviating myocardial apoptosis after AMI. CONCLUSIONS Perindopril inhibits myocardial apoptosis in mice with AMI through the TLR4/NF-κB pathway.
Pneumotonometer Accuracy Using Manometric Measurements after Radial Keratotomy, Clear Corneal Incisions and Lamellar Dissection in Porcine Eyes

ABSTRACT Purpose/Aim of the study Measured intraocular pressure (IOP) after corneal incisions may not be reflective of the true IOP because of changes in corneal biomechanical properties. The purpose of this study is to investigate the effect of various corneal incisions on pneumotonometer accuracy in enucleated porcine eyes. Materials and Methods A pneumotonometer was used to measure IOP (IOPp) at manometrically controlled pressure levels of 10, 20, 30 and 40 mmHg in enucleated porcine eyes. IOP measurements at each level were repeated after one of the following corneal incisions: radial keratotomy (8 eyes), lamellar dissection (10 eyes), clear cornea standard phacoemulsification incisions (10 eyes). The pneumotonometer error, defined as the difference between IOPp and manometric pressure (IOPm), was calculated for each pressure level. The error before the corneal incisions was compared to the error after the corneal incisions to assess the accuracy of the pneumotonometer. Results The pneumotonometer underestimates true IOP at all pressure levels, both before and after the corneal procedures. There was a statistically significant greater underestimation of IOP after radial keratotomy incisions at pressure levels of 20, 30 and 40 mmHg (p = .013, 0.004, and 0.002, respectively). There was no statistically significant difference in the amount of pneumotonometer underestimation error after lamellar dissection or standard cataract incisions. Conclusion The pneumotonometer underestimates true IOP in enucleated porcine eyes at all pressure levels between 10–40 mmHg. Radial keratotomy incisions caused a statistically significant greater underestimation error in pneumotonometry measurements at pressures of 20–40 mmHg. Lamellar dissection and clear corneal cataract incisions did not cause an additional error in pneumotonometry measurements in enucleated porcine eyes.
Enhancement of self compassion in psychotherapy: The role of therapists’ interventions

Abstract Aim: Self Compassion (SC) has been consistently linked to decreased emotional distress and is offered as a mechanism of change in several therapeutic approaches. The current study aimed to identify therapists’ interventions that enhance clients’ SC within individual psychodynamic psychotherapy. We examined a diverse set of interventions as predictors of clients’ SC, on treatment and session levels. We hypothesized that improvement in SC will be associated with greater use of directive or common factor interventions. Method: Client/therapist (N = 89) dyads from a university-based community clinic participated in the study. Therapists’ interventions and changes in clients’ SC level were monitored at each psychotherapy session. Results: Clients’ SC in a given session was not predicted by therapist use of interventions from any of the three clusters in the previous session. However, positive change in SC across treatment was predicted by greater use of directive interventions. Furthermore, among clients with low pretreatment SC, a positive change in SC across treatment was predicted by lesser use of common factor interventions. Discussion: The results highlight the importance of understanding clients’ pretreatment characteristics when selecting therapeutic interventions and suggest that the integration of directive interventions into the psychodynamic therapeutic practice may be beneficial in enhancing clients’ SC.
Effect of cognitive-only and cognitive-motor training on preventing falls in community-dwelling older people: protocol for the smart±step randomised controlled trial

Background Physical and cognitive impairments are important risk factors for falls in older people. However, no studies have been adequately powered to examine whether cognitive or cognitive-motor training can prevent falls in older people. This is despite good evidence of improvements in fall-related cognitive and physical functions following both intervention types. This manuscript describes the study protocol for a three-arm randomised controlled trial to evaluate the effectiveness of home-based cognitive and cognitive-motor training interventions, compared to a minimal-intervention control group, in preventing falls in older people. This trial was prospectively registered with the Australia New Zealand Clinical Trial Registry, number ACTRN12616001325493. Methods and analysis Community-dwelling adults aged 65 years and over, residing in Sydney Australia, will be recruited. Participants (n=750) will be randomly allocated to (1) cognitive-only training, (2) cognitive-motor training or (3) control groups. Both training interventions involve the use of the smart±step home-based computerised game playing system for a recommended 120 min/week for 12 months. Cognitive training group participants will use a desktop electronic touch pad to play games with the smart±step system while seated and using both hands. The cognitive-motor training group participants will use a wireless electronic floor step mat that requires accurate stepping using both legs for playing the same smart±step games, hence incorporating balance exercises. All groups will receive an education booklet on fall prevention. The primary outcome will be rate of falls, reported by monthly diaries during the 12-month duration of the study and analysis will be by intention-to-treat. Secondary outcomes include the proportion of fallers, physical and cognitive performance in 300 participants, and brain structure and function in 105 participants who will undertake MRI scans at baseline and 6 months. Cost-effectiveness will be determined using intervention and health service costs. Ethics and dissemination Ethical approval was obtained from UNSW Ethics Committee in September 2015 (ref number HC15203). Outcomes will be disseminated through publication in peer-reviewed journals and presentations at international conferences. Trial registration number ACTRN12616001325493
Assessment of Transporter Polymorphisms as a Factor in a BCRP Drug Interaction Study With Lanabecestat

Lanabecestat is a human β‐site amyloid precursor protein‐cleaving enzyme 1 inhibitor in development to slow disease progression in patients with early Alzheimer's disease. The study evaluated the breast cancer resistance protein (BCRP) inhibition potential of lanabecestat on the pharmacokinetics (PK) of rosuvastatin, a probe for BCRP activity, in healthy white subjects who were not carriers of SLCO1B1 (c.521T>C), not homozygotes for ABCG2 (c.421C>A or c.34G>A), and not heterozygotes of ABCG2 (c.421C>A and c.34G>A). The safety of lanabecestat + rosuvastatin, the effects of rosuvastatin on the PK of lanabecestat, and the effects of multiple genetic polymorphisms on rosuvastatin exposure were assessed. Geometric mean ratios of the maximum observed rosuvastatin concentration (Cmax), area under the rosuvastatin concentration‐versus‐time curve (AUC) from time 0 to infinity, and time of maximum observed drug concentration (tmax) when rosuvastatin was administered alone and with lanabecestat were contained within 0.8‐1.25, as were lanabecestat AUC at steady state and tmax at steady state when lanabecestat was administered alone or with rosuvastatin. Lanabecestat Cmax at steady state increased 8% in the presence of rosuvastatin. Except for an approximately 80% increase of rosuvastatin AUC (P < .05) in the heterozygotes of ABCG2 c.421C>A relative to the CC genotype, there were no statistically significant associations between rosuvastatin exposure and polymorphisms assessed. Lanabecestat + rosuvastatin was associated with few treatment‐emergent adverse events, all of which resolved and were mild. Lanabecestat does not meaningfully impact BCRP activity; therefore, restriction of concomitant administration with BCRP substrates, such as rosuvastatin, may be unnecessary.
Long noncoding RNA ZFAS1 acts as an oncogene by targeting miR-193a-3p in human non-small cell lung cancer.

Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "Long noncoding RNA ZFAS1 acts as an oncogene by targeting miR-193a-3p in human non-small cell lung cancer, by H. -B. Ge, S. Chen, S. -R. Huang, J. Zhu, published in Eur Rev Med Pharmacol Sci 2019; 23 (15): 6516-6523-DOI 10.26355/eurrev_201908_18535-PMID: 31378891" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview. org/article/18535.
Safety and Efficacy of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease: A Nationwide, Multicenter Cohort Study

Immune checkpoint inhibitors (ICIs) for cancer therapy frequently induce immune‐related adverse effects (IRAEs). Therefore, most patients with preexisting autoimmune diseases have been excluded from clinical trials of ICIs. This study was undertaken to evaluate the safety and efficacy of ICIs in patients with preexisting autoimmune disease and cancer.
Single amyloid‐beta injection exacerbates 4‐aminopyridine‐induced seizures and changes synaptic coupling in the hippocampus

Accumulation of amyloid‐beta (Aβ) in temporal lobe structures, including the hippocampus, is related to a variety of Alzheimer's disease symptoms and seems to be involved in the induction of neural network hyperexcitability and even seizures. Still, a direct evaluation of the pro‐epileptogenic effects of Aβ in vivo, and of the underlying mechanisms, is missing. Thus, we tested whether the intracisternal injection of Aβ modulates 4‐aminopyridine (4AP)‐induced epileptiform activity, hippocampal network function, and its synaptic coupling. When tested 3 weeks after its administration, Aβ (but not its vehicle) reduces the latency for 4AP‐induced seizures, increases the number of generalized seizures, exacerbates the time to fully recover from seizures, and favors seizure‐induced death. These pro‐epileptogenic effects of Aβ correlate with a reduction in the power of the spontaneous hippocampal network activity, involving all frequency bands in vivo and only the theta band (4–10 Hz) in vitro. The pro‐epileptogenic effects of Aβ also correlate with a reduction of the Schaffer‐collateral CA1 synaptic coupling in vitro, which is exacerbated by the sequential bath application of 4‐AP and Aβ. In summary, Aβ produces long‐lasting pro‐epileptic effects that can be due to alterations in the hippocampal circuit, impacting its coordinated network activity and its synaptic efficiency. It is likely that normalizing synaptic coupling and/or coordinated neural network activity (i.e., theta activity) may contribute not only to improve cognitive function in Alzheimer's disease but also to avoid hyperexcitation in conditions of amyloidosis.
Diffuse, mottled hyperpigmentation and mutations in LMNA gene in a 5‐year‐old boy, his mother, and his grandmother: Atypical progeroid syndrome

We present a multigenerational family with a phenotypic spectrum of skin dyspigmentation, lipodystrophy, bony anomalies, and progeroid facies. All were found to be heterozygous for a c.11C>G (p.Pro4Arg) (P4R) mutation in the lamin A/C gene consistent with atypical progeroid syndrome. Various phenotypic associations have been reported with specific mutations in atypical progeroid syndrome, but the strength of each phenotype‐genotype relationship is unknown. This report adds to the literature of patients with atypical progeroid syndrome and highlights an unusual diagnosis that may present to dermatologists.
Algorithms for convex optimization with applications to data science

Algorithms for convex optimization with applications to data science Scott Roy Chair of the Supervisory Committee: Assistant Professor Dmitriy Drusvyatskiy Department of Mathematics Convex optimization is more popular than ever, with extensive applications in statistics, machine learning, and engineering. Nesterov introduced optimal first-order methods for large scale convex optimization in the 1980s, and extremely fast interior point methods for small-to-medium scale convex optimization emerged in the 1990s. Today there is little reason to prefer modelling with linear programming over convex programming for computational reasons. Nonetheless, there is room to improve the already sophisticated algorithms for convex optimization. The thesis makes three primary contributions to convex optimization. First, the thesis develops new, near optimal barriers for generalized power cones. This is relevant because the performance of interior point methods depends on representing convex sets with “small parameter” barriers. Second, the thesis introduces an intuitive, first-order method that achieves the best theoretical convergence rate and has better performance in practice than Nesterov’s method. The thesis concludes with a framework for reformulating a convex program by interchanging the objective function and a constraint function. The approach is illustrated on several examples.
Adaptive Ontology based on Cross Phrase Identification in e-Government

Currently, the implementation of interoperability in e-Government services becomes very crucial. It is the connection of different systems and different schema of applications managed by different administrations. The system is very important in supporting e-Government for achieving good services. Therefore, it has to ensure good quality of services. Discrepancies in data and system structure have caused problems to interlink between systems. In this paper, we propose a method for cross-phrase identification of semantic relation based on word similarity measurement and morposemantic relations for e-Government services. It will solve the interoperability of e-Government services using heterogeneity data to make adaptive ontology.
Novel therapeutics in hairy cell leukemia

ABSTRACT Introduction: Hairy Cell Leukemia (HCL) is an indolent lymphoproliferative disorder resulting in a high complete response rate when treated with purine nucleoside analogs. However, at some time, nearly all patients relapse. In the relapsed setting, historically, options beyond repeat treatment with a purine nucleoside analog were limited. A number of novel agents have now been prospectively studied clinically for HCL in this setting. Areas covered: A review of the prospective data on newer agents in the relapsed setting is discussed. Emphasis is placed on overall response rates, complete response rates, minimal residual disease rates, and toxicities. The drugs vemurafenib, moxetumumab-pasudotox, bendamustine, and ibrutinib, all of which are commercially available, are reviewed in greatest detail. Expert opinion: Despite the number of prospective studies recently published on these agents in HCL, questions remain about which agents to use, when to best utilize them, how to best dose or schedule them, and the role of combination therapy. Further clinical research is required to answer these questions and to discover other drugs effective in the treatment of relapsed HCL.
Biosimilars of low molecular weight heparins: Relevant background information for your drug formulary

Biosimilars of low molecular weight heparins (LMWHs) are more alike the originator than different branded LMWHs. The latter differ largely in molecular weight, anti‐FXa/anti‐FIIa ratio and antithrombin binding. The Food and Drug Administration and European Medicines Agency guidelines are sufficient for the clinical use of high quality LMWHs. However, the Food and Drug Administration guideline lacks the results of a phase I clinical trial in the approval process. Most information about biosimilars is available for enoxaparin given that many biosimilars of enoxaparin have received market access. The guidelines of many International Thrombosis Societies for LMWH biosimilars are too stringent, not updated and impractical for formulary uptake discussions. This review gives background information on critical factors for the formulary uptake process of LMWHs with special attention for the use of the System of Objectified Judgment Analysis/Infomatrix model.
A survey of text mining in social media facebook and twitter perspectives

Text mining has become one of the trendy fields that has been incorporated in several research fields such as computational linguistics, Information Retrieval (IR) and data mining. Natural Language Processing (NLP) techniques were used to extract knowledge from the textual text that is written by human beings. Text mining reads an unstructured form of data to provide meaningful information patterns in a shortest time period. Social networking sites are a great source of communication as most of the people in today’s world use these sites in their daily lives to keep connected to each other. It becomes a common practice to not write a sentence with correct grammar and spelling. This practice may lead to different kinds of ambiguities like lexical, syntactic, and semantic and due to this type of unclear data, it is hard to find out the actual data order. Accordingly, we are conducting an investigation with the aim of looking for different text mining methods to get various textual orders on social media websites. This survey aims to describe how studies in social media have used text analytics and text mining techniques for the purpose of identifying the key themes in the data. This survey focused on analyzing the text mining studies related to Facebook and Twitter; the two dominant social media in the world. Results of this survey can serve as the baselines for future text mining research.