Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of circulating E/S antigens in the sera of patients with fascioliasis by IELISA: a tool of serodiagnosis and assessment of cure

Summary An IELISA was developed to evaluate the performance of Fasciola E/S antigens in diagnosis and cure assessment of human Fasciola infection. Twenty patients with acute (prepatent) fascioliasis and another 20 with patent infection were enrolled in the study. Patients were treated with TCZ and followed at 1, 3 and 6 months after therapy. At inspection, the sensitivity of the test to diagnose prepatent cases was 100% compared to 70% for patent infections. There was a gradual decrease of antigenaemia over the follow‐up period in acute cases. In chronic cases antigen disappeared from 13 cases (65%) at 1 month; this proportion did not change at 3 or 6 months.
Mobile-Assisted Vocabulary Learning in Real-Life Setting for Primary School Students: Two Case Studies

In recent years, we witness the rise of communicative and contextualized approaches in language learning theories concomitant with developments in the paradigm of Mobile-Assisted Language Learning (MALL). In this paper, we present two novel case studies in MALL that emphasize "creative learner outputs". In learning English prepositions and Chinese idioms respectively, students in the two studies used mobile devices on a 1:1 basis to capture photos of the real-life contexts pertaining to the prepositions or idioms, and to construct sentences with them. Subsequently, in-class or online sharing and discussions took place, enhancing the students' understanding in the proper usage of the prepositions or idioms. The learning designs are grounded in the seamless learning model [1] that encompasses in-class formal learning and out-of-class informal setting, and personal and social learning spaces. The student learning processes and artifacts have manifested some indicators of "seamless language learning" that has the potential of transforming language learning into an authentic learning experience.
Review: Hypertension and the cardiometabolic syndrome in Chile: a review of concepts and consequences for the developing world

We review some recent developments regarding the concept of cardiometabolic syndrome and its relation with hypertension and overall cardiovascular disease risk. We emphasize how this new clinical entity has helped to understand multimorbidity in chronic diseases. This concept has important consequences for individual patient treatment as well as public health policy. The challenge derived from cardiovascular disease and other chronic conditions is increasing worldwide, but the highest burden is located in the developing world. Thus, new and cost-effective approaches are needed for diseases that are mainly occurring in the poorest and less educated populations. We illustrate this situation analyzing hypertension and cardiometabolic syndrome data derived from a recent national health survey in Chile.
Ezetimib - první zástupce selektivních inhibitorů cholesterolové absorpce

Soucasný přistup hypolipidemicke terapie zahrnuje vedle dietnich opatřeni a využiti již znamých a ověřených hypolipidemik take vývoj nových leciv zasahujicich na různe urovni do metabolizmu cholesterolu. Novinkou na poli hypolipidemik je ezetimib. Jedna se o prvniho zastupce skupiny selektivnich inhibitorů absorpce cholesterolu. Inhibuje vstřebavani žlucoveho a dietniho cholesterolu v tenkem střevě bez ovlivněni absorpce vitaminů rozpustných v tucich, triacylglycerolů a žlucových kyselin. Mistem jeho farmakologickeho ucinku je kartacový lem tenkeho střeva, kde snižuje uptake cholesterolu do enterocytu. Existuje cela řada preklinických i klinických studii demonstrujici přiznivý vliv ezetimibu na hladinu cholesterolu při monoterapii, ale take jeho synergický efekt při soucasnem podavani inhibitoru HMG-CoA reduktazy (statinu). Ezetimib podavaný samostatně nebo v kombinaci se statinem signifikantně snižuje hladiny LDL-cholesterolu a zvysuje hladiny HDL-cholesterolu. Lecivo je pacienty poměrně dobře tolerovano a incidence nežadoucich ucinků se bliži placebu. V klinicke praxi je ezetimib v monoterapii urcen pacientům, u kterých je žadouci mirne sniženi LDL-cholesterolu nebo u nichž jsou kontraindikovana hypolipidemika jiných skupin. Kombinovana terapie se statinem je indikovana pacientům, kteři hůře toleruji vysokou davku statinu nebo u nichž nelze cilových hodnot LDL-cholesterolu dosahnout maximalni davkou statinu.
Co-simulation of capacitive coupling pads assignment for capacitive coupling interconnection applications

Three dimensions packaging provides a very promising technology for the effective integration of complex systems: devices that are optimally implemented with various different technologies can be separately manufactured and then stacked and connected by means of efficient vertical interconnections over a very short range; this provides most of the benefits of inter-chips for high-bandwidth with a reasonable cost and short development time in the advance of CMOS processes and assembly. This study presents the co-simulation of capacitive coupling pads assignment for the capacitive coupling interconnection. The modelling of a close capacitive coupling interconnection pad is represented by a lumped circuit. The coupling pads of parasitic capacitance are one of the parasitic parameters. The FEM (finite element method) tools simulation results show that the effect of cross-coupling between adjacent channels is dependent on substrate characteristic and pads arrangement. A comparison between simulated and measured circuit performance was shown for a RLC-elements, and qualitative accuracy was obtained. HSPICE tools are applied for the circuit simulations using the equivalent model of coupling pads. Based on the findings of this work, co-simulation methods can reduce simulation time dramatically, the coupling pads assignment can be translated to HSPICE model.
Structural brain changes following subthalamic nucleus deep brain stimulation in Parkinson's disease

Per Svenningsson, MD, PhD,* Karin Wirdefeldt, MD, PhD, Li Yin, PhD, Fang Fang, PhD, Ioanna Markaki, MD, PhD, Suad Efendic, MD, PhD, Jonas F. Ludvigsson, MD, PhD, Departments of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Molecular Medicine and Surgery, Rolf Luft Center for Diabetes Research, Karolinska Institutet, Stockholm, Sweden Department of Pediatrics, € Orebro University Hospital, € Orebro, Sweden Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, City Hospital, Nottingham, United Kingdom
Intravaginal progesterone devices in synchronization protocols for artificial insemination in beef heifers.

Two experiments were designed to investigate the administration of intravaginal progesterone in protocols for oestrus and ovulation synchronization in beef heifers. In Experiment 1, cyclic Black Angus heifers (n = 20) received an Ovsynch protocol and were randomly assigned to receive (CIDR-Ovsynch) or not (Ovsynch) a progesterone device between Days 0 and 7. Treatment with a controlled internal drug release (CIDR) device significantly increased the size of the dominant follicle prior to ovulation (12.8 ± 0.4 CIDR-Ovsynch vs 11.4 ± 0.4 Ovsynch) (p < 0.02). Plasma progesterone concentrations throughout the experiment were affected by the interaction between group and day effects (p < 0.004). In Experiment 2, cyclic Polled Hereford heifers (n = 382) were randomly assigned to one of the six treatment groups (3 × 2 factorial design) to receive a CIDR, a used bovine intravaginal device (DIB), or a medroxiprogesterone acetate (MAP) sponge and GnRH analogues (lecirelin or buserelin). All heifers received oestradiol benzoate plus one of the devices on Day 0 and PGF on Day 7 pm (device withdrawal). Heifers were detected in oestrus 36 h after PGF and inseminated 8-12 h later, while the remainder received GnRH 48 h after PGF and were inseminated on Day 10 (60 h). The number of heifers detected in oestrus on Day 8 and conception rate to AI on Day 9 were higher (p < 0.01) in the used-DIB than in the CIDR or MAP groups, while the opposite occurred with the pregnancy rate to FTAI on Day 10 (p < 0.01). There was no effect of progesterone source, GnRH analogue or their interaction on overall pregnancy rates (64.9%). Progesterone treatment of heifers during an Ovsynch protocol resulted in a larger pre-ovulatory follicle in beef heifers. Progesterone content of intravaginal devices in synchronization protocols is important for the timing of AI, as the use of low-progesterone devices can shorten the interval to oestrus.
Phylogeography of mitochondrial DNA variation in brown bears and polar bears.

We analyzed 286 nucleotides of the middle portion of the mitochondrial cytochrome b gene of 61 brown bears from three locations in Alaska and 55 polar bears from Arctic Canada and Arctic Siberia to test our earlier observations of paraphyly between polar bears and brown bears as well as to test the extreme uniqueness of mitochondrial DNA types of brown bears on Admiralty, Baranof, and Chichagof (ABC) islands of southeastern Alaska. We also investigated the phylogeography of brown bears of Alaska's Kenai Peninsula in relation to other Alaskan brown bears because the former are being threatened by increased human development. We predicted that: (1) mtDNA paraphyly between brown bears and polar bears would be upheld, (2) the mtDNA uniqueness of brown bears of the ABC islands would be upheld, and (3) brown bears of the Kenai Peninsula would belong to either clade II or clade III of brown bears of our earlier studies of mtDNA. All of our predictions were upheld through the analysis of these additional samples.
Plate 1 Pseudomonas aeruginosa Proteus vulgaris Salmonella typhi Staphylococcus aureus Escherichia coli Staphylococcus aureus Plate II Pseudomonas aeruginosa Staphylococcus aureus Salmonella typhi Staphylococcus aureus Escherichia coli Proteus vulgaris

Medicinal plants are very interesting have the ability to produce remarkable chemical structures with diverse biological activities. Biophytum sensitivum L. DC (Oxalidaceae) is used as traditional medicine to cure various disease and also is an ethnomedicinal plant used in folk lore medicine. The main aim of this study demonstrates the root extracts of Biophytum sensitivum (Acetone, Benzene, Ethanol, Iso-prophyl alcohol and Nbutyl alcohol) was evaluated for its antibacterial activity against several human pathogenic bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Proteus vulgaris) by disc agar diffusion method. All the extracts showed various levels of activity on different test organisms and their activity is quite comparable with the standard antibiotics. The n-butyl alcohol extracts of Biophytum sensitivum root showed remarkable anti bacterial activity against Staphylococcus aureus. The results from these investigations encourage that the plant extracts may be used as anti-infective agents.
Pituitary-gonadal axis in sterile male mice heterozygous for autosomal reciprocal translocation T145H.

Male mice heterozygous for the reciprocal autosomal translocation T(7,19)145H (T145H/+) were completely sterile, Spermatogenesis was arrested at some stage during the first meiotic division. The pituitary-gonadal axes of these mice were compared with those of normal male littermates (+/+) at 63 days of age. Testis and epididymis weights were significantly lower than in normal males, but no deficiencies in circulating FSH were observed despite drastic loss of germinal cells, suggesting that spermatids were not involved in the feed-back control of FSH (T145H/+, 2155 +/- 64 ng/ml; +/+, 1830 +/- 94 ng/ml; mean +/) s.e. m. ). Androgen activity in T145H/+ males seemed normal judging by weights of androgen target tissues (prostate, seminal vesicles), serum LH and testosterone levels (T145H/+ : LH = 132 +/- 19 ng/ml, testosterone = 5.5 +/- 2.8 ng/ml; +/+ : LH = 127 +/- 22 ng/ml, testosterone = 7.4 +/- 2.7 ng/ml). These results indicate that the translocation in the heterozygous state does not modify control of FSH secretion or the LH-interstitial cell axis.
Insomnia: Current Treatment and Recent Advances

Insomnia is defined as difficulty with the initiation, maintenance, duration or quality of sleep which affects daytime functioning. About one third of world population suffer from insomnia. It can be classified by various ways i.e. primary or secondary; transient, short term or chronic insomnia; or difficulty in onset or difficulties in maintaining sleep. The derangement of various neurotransmitters e.g. histamine, orexins, noradrenaline, acetylcholine and serotonin leads to insomnia. Predisposing conditions leading to insomnia are familial or genetic tendency, illness, stress and maladaptive sleep habits. Insomnia leads to chronic fatigue, inattention, irritability, emotional outbursts, absence from work, diminished productivity, risk of accidents and other health related problems. The treatment options for insomnia include cognitive behavioural therapy, pharmacological therapy and combined approach. Cognitive behavioural therapy includes stimulus control therapy, sleep restriction therapy, relaxation therapy, sleep hygiene and cognitive therapy. The pharmacological options currently widely in use are benzodiazepines and Z-drugs. Alternative drug delivery methods and innovative treatments hold promise for increasing access to care and accelerating improvement. The newer targets for treatment of insomnia are orexin receptors, melatonin receptors and serotonin receptors. A combined approach of pharmacological treatment, cognitive behavioural treatment and newer formulations for improving drug delivery is required to combat the problem of insomnia.
RELATIVE SUCCESS OF SELF AND OUTCROSS POLLEN COMPARING MIXED‐ AND SINGLE‐DONOR POLLINATIONS IN AQUILEGIA CAERULEA

Flowers frequently receive both self (S) and outcross (OC) pollen, but S pollen often sires proportionally fewer seeds. Failure of S pollen can reflect evolved mechanisms that promote outcrossing and/or inbreeding depression expressed during seed development. The relative importance of these two processes was investigated in Aquilegia caerulea, a self‐compatible perennial herb. In the field I performed single‐donor (S or OC) and mixed‐donor (S plus OC) pollinations to compare the relative success of both pollen types at various stages from pollen germination to seed maturity. Single‐donor S pollinations produced significantly fewer and lighter seeds (x decrease = 12% and 3%, respectively) than OC pollinations. Abortion rates differed by an average of 38% whereas fertilization rates differed by only 5%, indicating that most differences in seed number arose postzygotically. This suggests that inbreeding depression was responsible for most failure of S pollen. One prezygotic effect measured was that 10% fewer S than OC pollen tubes reached ovaries after 42 hr, suggesting S pollen might fertilize proportionately fewer ovules after mixed pollination. Using allozyme markers, I found mixed‐donor pollinations produced significantly more and heavier outcrossed than selfed seeds. However, the proportion of selfed seed, fertilized ovules, and aborted seeds for mixed‐donor fruits were each predictable from pollen performance in single‐donor fruits, suggesting that differential paternity is best explained by inbreeding depression during seed development. Even given these similarities between mixed‐ and single‐donor fruits in the relative performance of S and OC pollen, both individual seed weight and seed set were significantly higher in multiply‐sired fruits.
Quantitative optical microscope with enhanced resolution using a pixelated liquid crystal spatial light modulator

This paper presents a brief account of a novel optical microscope, which combines the advantages of two well‐known techniques, namely phase contrast and phase stepping, to provide high contrast imaging and precision measurements. The inclusion of a programmable liquid crystal spatial light modulator provides for the phase stepping required, while also allowing flexibility for future improvements. The results shown reveal an important aspect of the system to facilitate quantitative sample measurements, with an enhancement of optical resolution compared with conventional optical imaging systems.
Primary Constrained Condylar Knee Arthroplasty for the Arthritic Valgus Knee

The purpose of the current study was to review results of primary constrained condylar knee arthroplasty in elderly patients with genu valgum deformity. The hypotheses were: (1) constraint has no adverse effects in elderly patients; (2) treating deformity with a constrained condylar knee prosthesis in lieu of lateral ligament release avoids morbidity, particularly peroneal nerve palsy and flexion instability; and (3) press-fit noncemented stem extensions enhance fixation of the cemented core components and are not prone to loosening. Between 1988 and 1993, 44 consecutive primary Constrained Condylar Knee prostheses were implanted in 37 patients (average age, 72.7 years) with an average valgus angle of 17.6°. Indications for the Constrained Condylar Knee implant were: elderly patients with genu valgum deformity and medial collateral ligament incompetence. Outcome was assessed prospectively using the Hospital for Special Surgery and Knee Society scoring systems; followup was by independent observer. Clinical and radiographic followup (average, 7.8 years) was available for 28 knees (26 patients). The Hospital for Special Surgery score improved from 52.2 to 89.6 points. The average Knee Society score and functional scores improved from 27.4 and 32.4 points to 95.2 and 67.2 points, respectively. At followup, the average alignment based on anteroposterior radiographs obtained with the patient weightbearing was 5.3°. No radiographic loosening, prosthetic failures, peroneal nerve palsies, or flexion instability occurred. No failures occurred in the 11 patients (16 knees) who died before the latest followup. To the authors’ knowledge, this is the largest reported series with the longest reported followup of patients with primary Constrained Condylar Knee prostheses. The use of the Constrained Condylar Knee prosthesis for elderly patients with low physical demands with genu valgum resulted in significant pain relief and improved function.
Hydrodynamic theory of the glass transition.

Les equations de l'hydrodynamique pour un fluide compressible simple, en incluant non-linearites et fluctuations thermiques, indiquent une transformation par un etat vitreux pour des densites suffisamment hauts et des temperatures suffisamment basses. Comportement des viscosites, vitesses du son et fonctions de correlation au voisinage de la transformation
Low-Complexity Model Predictive Power Control: Double-Vector-Based Approach

Conventional model predictive power control (MPPC) achieves good steady-state performance and quick dynamic response by minimizing a cost function relating to the power errors. However, applying single voltage vector during the whole control period fails to reduce the power ripples to a minimal value; particularly in the two-level converter with limited switching states. Recently, the concept of duty cycle control has been introduced in MPPC to achieve further power ripple reduction. Although better steady-state performance is obtained, a lot of calculations are needed when deciding the best voltage vector and its corresponding duration. This paper proposes a low-complexity MPPC with quick voltage selection and fast duty cycle calculation. Different from prior MPPC, the negative conjugate of complex power in synchronous frame is selected as the control variable. As a result, only one prediction is required to select the best voltage vector, and its duration is determined base on the principle of error minimization of both active and reactive power. Further study reveals that the proposed low-complexity MPPC is equivalent to the recently reported MPPC with duty cycle control. Simulation and experimental results obtained from a two-level three-phase ac/dc converter are presented to confirm the theoretical study and the effectiveness of the proposed method.
Design of energy storage system with flywheel and electrical drives

In modern industries like paper mills, food processing industries use highly sensitive microprocessor and high frequency power electronic device, for that purpose reliability of power demand should be high. Due to unsymmetrical faults and unbalance load power quality issue occur, to counter this issues we can used flywheel energy storage system Flywheel store electrical energy into kinetic energy release out upon demand, FESS system can charge or discharge in quick time and give large amount of energy. This paper gives review on different type of FESS using different type of flywheel and motor.
Feeling the beat: Temporal and spatial perception of heartbeat sensations

The majority of interoceptive tasks (i.e. measuring the sensitivity to bodily signals) are based upon the heartbeat sensations perception. However, temporal perception of heartbeats varies among individuals and confidence and spatial perception of heartbeats in relation to temporal judgements have not yet been systematically investigated. This study examined the perception of heartbeat sensations in both time and spatial domains, using a multi-interval heartbeat discrimination task. The relationship between these domains was investigated, as well as the contribution of mental health conditions and cardiovascular parameters. Heartbeat sensations occurred on average ~250ms after the ECG R-wave and were more frequently sampled from the left part of the chest. Participants’ confidence in their experience of heartbeat sensations was maximal for the 0 ms interval. Interestingly, higher confidence was related to reduced dispersion of sampling locations but we found evidence toward the absence of relationship between temporal and spatial heartbeat sensations perception, using Bayesian statistics. Finally, we found evidence toward a relationship between spatial precision of heartbeat sensations and state anxiety score, which seems independent from the cardiovascular parameters. This systematic investigation of heartbeat sensations perception provides important fresh insights, informing the mechanistic understanding of the interoceptive signaling contribution to emotion, cognition and behaviour.
BrightArm duo integrative rehabilitation for post-stroke maintenance in skilled nursing facilities

Purpose: To determine clinical benefits of the BrightArm Duo bimanual upper extremity (UE) rehabilitation system for maintenance of older hemiplegic residents of Skilled Nursing Facilities (SNFs). Methods: The system underwent a longitudinal controlled study in two SNFs. Seven chronic post-stroke participants trained for 8 weeks of increasingly intensive sessions followed by a 2 week booster period starting 10 weeks later. The sessions involved computer games designed to improve UE motor deficits, function, cognition and emotive state. BrightArm Duo recorded arm reach, arm active movement repetitions, hand grasps, and game performance. The control group (N=3) continued with normal maintenance programs offered in their SNF. Participants' motor function was evaluated pre-therapy, post-therapy, and pre-booster and post-booster using standard clinical measures. Participants' cognition was evaluated pre- and post- initial intervention and post-booster. Outcomes: The experimental group significantly improved in shoulder strength, grasp strength, active range of movement, supported arm reach and depression. The motor function and emotive levels post-booster were much higher than post- initial training. The experimental group motor, emotive, and cognitive outcomes were much better than for the control group. Conclusions: Initial results are promising for the integration of the BrightArm Duo in maintenance programs of SNF residents.