Miracle-dz/UniFAR-FTUs huggingface dataset:
Offener Zugang - Open Access, Open Educational Resources und Urheberrecht

Fur Forschende und Lehrende hat das Internet weitreichende Auswirkungen auf die Recherche von Materialien und Texten, das Publikationsverhalten sowie auf die Nutzung und den Austausch von Lehr- und Lernressourcen. Vorhandene, tradierte Urheberrechtsregelungen werden durch neuartige Lizenzmodelle modifiziert oder ersetzt. Die Forderungen nach „Open Access“ und „Open Educational Ressources“, die sich in zahlreichen Initiativen, Projekten und Aktivitaten niederschlagen, sind wichtig zur Gestaltung eines liberalen, offenen Zugangs zu Forschungs- und Bildungsmaterialien. In diesem Beitrag wird zunachst die Open-Access-Bewegung vorgestellt, deren Forderung nach freiem Zugang zu offentlich geforderten Forschungsergebnissen inzwischen als forschungspolitisch etabliert betrachtet werden kann. Parallel zu dieser Bewegung, aber wohl durch sie beeinflusst, bilden sich in den letzten zehn Jahren Projekte und Initiativen, die frei verwendbare Bildungsressourcen fordern und unterstutzen. Allein dass man etwas passendes im Internet entdeckt, beispielsweise einen Zeitungsartikel oder ein Foto, erlaubt namlich keineswegs dessen Verwendung im Schulunterricht, der Hochschullehre oder in einem Weiterbildungsseminar. Zitation des Kapitels Links auf Mister Wong This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License .
Pathogenesis of Theiler’s murine encephalomyelitis virus‐induced disease

Theiler’s murine encephalomyelitis virus (TMEV) is a member of the Cardiovirus genus of the Picornaviridae family. Interest in TMEV is at least partly related to the fact that the Daniels (DA) strain and other members of Theiler’s original (TO) subgroup induce an inflammatory demyelinating disease in which the virus persists for the life of the mouse. This disease resembles multiple sclerosis because of the similar pathology and because the immune system seems to play an important role in both. The present review describes features of TMEV and the importance of both virus persistence as well as the immune system in the pathogenesis of DA virus‐induced demyelinating disease. (Clin. Exp. Neuroimmunol. doi: 10.1111/j.1759‐1961.2010.00008.x, 2010)
Distributed live streaming on mesh networks

Internet is evolving in both its structure and usage patterns; this work addresses two trends: i) the increasing popularity and the related generated traffic of media streaming applications and ii) the emerging of network portions following different philosophies from the rest of the internet and being characterized by a mesh topology, such as Community Networks. This thesis presents a modeling for decentralized live streaming for mesh networks based on graph theory, considering the different inter-dependent network abstractions involved. It proposes optimization strategies based on popular centrality metrics, such as betweenness and PageRank. Results on real-world datasets validate the theoretical work and the derived optimizing strategies are implemented in open-source streaming platforms.
Abstract #5551: The impact of expression of BER proteins on therapeutic effect of combining temozolomide with methoxyamine in melanoma cells

Base excision repair (BER) is a highly coordinated cellular biochemical system essential to cell survival. Variability of expression of BER proteins may affect the dynamics of the repair pathway or change the repair rate that determines the cellular sensitivity to the cytotoxicity exerted by alkylating agents. In the present study, we examined the relationship between the expression of BER proteins and therapeutic effect of temozolomide (TMZ) and the combination of TMZ and methoxyamine (MX), a BER inhibitor, in melanoma cells in vitro and in xenografts. The levels of BER proteins (including MPG, UDG, APE, and Pol \#946;) were measured by western blotting assay in 4 cell lines, SkmCI-1, WM164, A375, and WM9. Results revealed that BER proteins were coordinately and differentially expressed in these melanoma cell lines, higher in A375 and much lower in WM164 cells. There were no significant differences in MGMT and MLH1-MSH2, two well known TMZ resistant factors in these two cell lines. To determine the role of BER proteins in TMZ cytotoxicity, clonogenic survival studies were performed in A375 and WM164 cells. The sensitivity to TMZ alone in these two cell lines was assessed by IC90 value produced by survival assay, showing 490 µM in A375 and 570 µM in WM164 cells. When cells were treated with the combination of TMZ and MX, MX efficiently potentiated TMZ cytotoxicity by 3 folds in A375 but failed to enhance the killing effect of TMZ in WM164 cells. Similar results were observed in xenografts. In xenograft study, MX enhanced TMZ antitumor effect, resulting in tumor growth delays of 13 days in mice receiving the combination of TMZ (80 mg/kg) and MX (2 mg/kg) i.p daily for five days in comparison to 6 days in mice treated with TMZ alone. No enhancement of TMZ-antitumor activity by MX was observed in mice carrying WM164 melanoma xenografts. The results suggest that the failure of TMZ-potentiation by MX in WM164 cells was related to the low activity of BER proteins, particularly low levels of MPG DNA glycosylase. Deficiency of the BER proteins would decrease the formation of AP sites, the targets for MX action. These results indicate that BER proteins may be differentially expressed in tumor cells, which particularly impact the therapeutic effect of combining TMZ with MX. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5551.
ANALYZING THE SERVICE QUALITY OF SILOAM HOSPITAL MANADO USING IMPORTANCE AND PERFORMANCE ANALYSIS (IPA)

Abstract: Hospital plays an important role in preventing disease and providing rehabilitation service to people. In current rapidly growing consumer-oriented health industry, quality has become the integral part. To meet the demand for world-class medical services by a growing Indonesian middle class as well as the demand from the introduction of the national health-care plan, private hospital is rapidly increasing the numbers of hospitals and broadening the service it offers. This research aims to analyze the service quality of Siloam Hospital Manado. The type of this research is a quantitative descriptive research. The Imporance Performance Analysis (IPA) was used in this research. The sample of this research is 100 respondents who already experience the service quality of Siloam Hospital Manado. The sample was taken by Purposive Sampling. This research suggests that Siloam Hospital needs to improve their performance and giving the best services for consumer. By doing so, it is hoped that their consumers will be satisfied and will be their loyal customers. Keywords: Service Quality, Importance Performance Analysis, Health-Care Industry, Hospital
Prevalence of Malaria among Malnutrition Under-five Children Admitted in Nutrition Centers in Northern Bahr el Ghazal State, South Sudan

Aims: The ongoing conflict in South Sudan has led to the disruption of health care services with a high burden of infectious diseases, a widespread food insecurity and elevated child malnutrition with malaria being a major cause of co-morbidity among malnourished children. This study assessed the prevalence of malaria among malnourished children and assessed the relationship between malaria and malnutrition among malnourished children in an area with a high degree of malaria transmission. Study Design: This was a retrospective chart review of children 6 month-5years admitted at the nutrition centers Place and Duration of Study: 49 nutrition centers in Northern Bahr el Ghazal state of South Sudan Original Research Article Oladeji et al.; ACRI, 15(2): 1-9, 2018; Article no.ACRI. 44439 2 between January 2017 and December 2017. Methodology: A retrospective chart review of sociodemographic, anthropometric and malaria testing data extracted from the treatment cards and registers of malnourished children admitted at the nutrition centre analysed using descriptive and inferential statistic by means of SPSS version 21. Chi square test was used to conduct bivariate analysis to assess the factors associated with malaria at a significant level of 5%. Results: Among the 2124 malnourished children admitted into the nutrition program, 873 (41.1%) had severe acute malnutrition (SAM) and 1251(58.9%) had moderate acute malnutrition. The prevalence of malaria was higher among children with moderate acute malnutrition with 43.2% being positive on testing to malaria compared to 36.4% among children with severe acute malnutrition and bivariate analysis done showed a significant association between malaria and nutritional status (p=0.001). Conclusion: Study highlighted the need for routine screening and testing for malaria to be included in the management protocols for all children admitted into both Outpatient Therapeutic Program and Supplementary Feeding Program in all Nutrition treatment centers to reduce the impact of malaria being a major co-morbidity in the treatment outcome of the children.
Vibration‐induced hearing loss: comparison of the protective efficacy of antioxidants and neurotrophins

Pre‐treatment with N‐acetylcysteine (NAC) or the neurotrophin brain derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) on vibration‐induced hearing loss (VHL) was tested in an animal model. NAC was delivered into the cochlea by round window membrane (RWM) injection, RWM permeation, or oral administration, and BDNF and CNTF were delivered with mini‐osmotic pumps. Hearing was evaluated with electrocochleography (ECoG). NAC provided no protective benefit in animals subjected to VHL, irrespective of delivery method. NAC injection through the round window membrane was toxic, causing an ECoG threshold shift of >25 dB. In BDNF + CNTF treated animals, there was statistically significant improved threshold recovery post‐vibration.
Learning from Museums: Visitor Experiences and the Making of Meaning

Chapter 1 Foreword Chapter 2 Preface Chapter 3 Learning from Museums: An Introduction Chapter 4 The Personal Context Chapter 5 The Sociocultural Context Chapter 6 The Physical Context Chapter 7 Museums and the Individual Chapter 8 Communities of Learners Chapter 9 A Place for Learning Chapter 10 The Contextual Model of Learning Chapter 11 Documenting Learning from Museums Chapter 12 Making Museums Better Learning Experiences Chapter 13 Museums in the Larger Society Chapter 14 The Future of Museums Chapter 15 Refrences
A Genetic Algorithm for Flow Scheduling in Data Center Networks

Traffic in today’s data center networks grows rapidly. Traditional routing and forwarding protocols in data center usually rely on static hashing, and may cause avoidable bottlenecks. We present a genetic algorithm to make better use of the resources. Our goal is to minimize the maximum single link utilization of the network. And results show that our algorithm performs better than a recent greedy algorithm.
GLP‐1 Is a Coronary Artery Vasodilator in Humans

Background The mechanism underlying the beneficial cardiovascular effects of the incretin GLP‐1 (glucagon‐like peptide 1) and its analogues in humans is elusive. We hypothesized that activating receptors located on vascular smooth muscle cells to induce either peripheral or coronary vasodilatation mediates the cardiovascular effect of GLP‐1. Methods and Results Ten stable patients with angina awaiting left anterior descending artery stenting underwent forearm blood flow measurement using forearm plethysmography and post–percutaneous coronary intervention coronary blood flow measurement using a pressure‐flow wire before and after peripheral GLP‐1 administration. Coronary sinus and artery bloods were sampled for GLP‐1 levels. A further 11 control patients received saline rather than GLP‐1 in the coronary blood flow protocol. GLP‐1 receptor (GLP‐1R) expression was assessed by immunohistochemistry using a specific GLP‐1R monoclonal antibody in human tissue to inform the physiological studies. There was no effect of GLP‐1 on absolute forearm blood flow or forearm blood flow ratio after GLP‐1, systemic hemodynamics were not affected, and no binding of GLP‐1R monoclonal antibody was detected in vascular tissue. GLP‐1 reduced resting coronary transit time (mean [SD], 0.87 [0.39] versus 0.63 [0.27] seconds; P=0.02) and basal microcirculatory resistance (mean [SD], 76.3 [37.9] versus 55.4 [30.4] mm Hg/s; P=0.02), whereas in controls, there was an increase in transit time (mean [SD], 0.48 [0.24] versus 0.83 [0.41] seconds; P<0.001) and basal microcirculatory resistance (mean [SD], 45.9 [34.7] versus 66.7 [37.2] mm Hg/s; P=0.02). GLP‐1R monoclonal antibody binding was confirmed in ventricular tissue but not in vascular tissue, and transmyocardial GLP‐1 extraction was observed. Conclusions GLP‐1 causes coronary microvascular dilation and increased flow but does not influence peripheral tone. GLP‐1R immunohistochemistry suggests that GLP‐1 coronary vasodilatation is indirectly mediated by ventricular‐coronary cross talk.
Experimental Design: Input Device Protocols and Collaborative Learning

This document outlines an experimental design for a study that investigates peer collaboration in a computer supported learning environment. Sections of this document have been adapted from a CPSC 533b term report by McGrenere et al. (1995) which outlined a similar experimental desgin. In the proposed study we examine different ways of supporting peer colloration which, for the purposes of this study, refers to two students working on a single comptuer playing an electronic game. The standard computer is configured with only one mouse and therefore when two students share a computer they need to share the mouse as well. We want to investigate the impact of adding second mouse to the configuration such that each child would have their own mouse.
2D Human Motion Regeneration with Stick Figure Animation Using Accelerometers

This paper explores the opportunity of using tri-axial wireless accelerometers for supervised monitoring of sports movements. A motion analysis system for the upper extremities of lawn bowlers in particular is developed. Accelerometers are placed on parts of human body such as the chest to represent the shoulder movements, the back to capture the trunk motion, back of the hand, the wrist and one above the elbow, to capture arm movements. These sensors placement are carefully designed in order to avoid restricting bowler’s movements. Data is acquired from these sensors in soft-real time using virtual instrumentation; the acquired data is then conditioned and converted into required parameters for motion regeneration. A user interface was also created to facilitate in the acquisition of data, and broadcasting of commands to the wireless accelerometers. All motion regeneration in this paper deals with the motion of the human body segment in the X and Y direction, looking into the motion of the anterior/ posterior and lateral directions respectively. Keywords—Motion Regeneration, Virtual Instrumentation, Wireless Accelerometers.
A counting method of the number of passing people using a stereo camera

Attempts to count the passing people by image processing have been made for some time. However, the conventional methods could not count the passing people accurately unless there were very few people passing through the gate at one time. In this paper, the authors propose an automatic method of counting passing people by using a stereo camera. In the proposed method, the stereo camera is hung from the ceiling of the gate and the optical axis of the camera is set up so that the passing people can be observed from just overhead. In this system arrangement, if there are a crowd of people in the gate, then the data of the passing people are not overlapped on the obtained images. In addition, by using the stereo camera, the human region and road region on the obtained images are able to be segmented accurately. In this paper, the authors show some experimental results obtained by using a simple experimental system to verify the effectiveness of the proposed method.
Isolement de xanthones et coumarines inhibitrices de l'acétylcholinestérase, respectivement à partir de "Gentianella campestris" (L.) Börner et "Gentianella amarella" (L.) Börner ssp. "acuta" (Michx.) J.M. Gillett (Gentianaceae), et "Peucedanum ostruthium" (L.) Koch (Apiaceae)

Lors d'un criblage visant a detecter des extraits vegetaux presentant une activite inhibitrice de l'acetylcholinesterase, trois especes se sont revelees significativement actives; deux Gentianaceae: "Gentianella campestris" et "Gentianella amarella" ssp. "acuta", et une Apiaceae: "Peucedanum ostruthium". Les composes d'interet ont ete isoles essentiellement par chromatographie de partage centrifuge. Dix xanthones - dont deux nouvelles, notamment une xanthone dimerique - ainsi qu'un flavonoide C- glycosyle ont ete caracterises a partir des deux especes de gentiane. De la meme maniere, le fractionnement bioguide de l'extrait de racines de "Peucedanum ostruthium" a conduit a l'obtention de cinq coumarines et d'une chromone. Parmi les dix-sept composes isoles, une xanthone - le triptexanthoside C - et trois coumarines ont montre une inhibition de l'enzyme particulierement interessante. L'ostruthol s'est notamment revele dix fois plus puissant que la galanthamine lors de tests "in vitro", activite confirmee " in vivo" chez la souris.
Anticoagulant therapy and varicose vein interventions

Phlebologie published in issue 2/2008 an article on procedures to be considered in patients on oral anticoagulant therapy who undergo elective varicose vein surgery (5). The authors present a second article in this issue of Phlebologie, again on the potential risk of bleeding during varicose vein surgery. This time, they reflect the role of anti-platelet therapy (4). Furthermore, the issue features a comment from the well-known Department of Haemostasis at the Charité in Berlin. It provides a reply to the recommendations on anticoagulant bridging in patients undergoing varicose vein surgery. The quality of the three papers and the recommendations advanced by the authors prompt me to say a word of clarification based on the international literature and the guidelines elaborated by our own society. My aim is to come up with recommendations that make sense and can be implemented easily. I firmly believe that the management of these patients should not be made unnecessarily cumbersome. First, some comments regarding the article of Dr. Miszczak (5): With regard to the peri-operative bridging of anticoagulant treatment they ask for stratification in two groups of risk nd recommend the use of a “half-therapeutic” dose of a low-molecularweight heparin if the risk is small and the “full-therapeutic” dose if the thrombo-embolic risk is considered high. However, for years patients were stratified in three groups of risk: small, moderate, and high. The authors present no reason why they depart from this approach. I also found the definition of bleeding complications quite prejudiced and subjective. Bruising and haematoma are common sequels of varicose vein surgery and they usually have no serious consequences. Bleeding should be quantified giving data on preand post-operative haemoglobin values, need for transfusions etc. Bridging
Why Greeks Interupt each other?: The phenomenon of 'overlaps' in everyday Greek conversations

This book deals with the study of how Greek grammar and syntax make possible the occurrence of overlaps in specific locations, in everyday Greek conversation. Greek grammar and syntax have specific functions (such as freer word order, much information included in the verb, subject omission) which allow interaction to occur in specific forms (displays early projectability and early occurrence of overlaps). The co-existence of the above grammatical and syntactical characteristics within a Greek turn, make possible the appearance of overlaps in specific locations. Consequently, syntactic practices of Modern Greek language shape the organisation of overlaps that occur in everyday Greek conversations. In Greek, grammar and interaction organise each other and more specifically syntactic practices of language shape the organization of overlaps. This book proposes that if over time the suggestions of this study are generalisable then it could be supported that social and national stereotypes (for example that Greeks are loud or impolite or that they talk all together and interrupt each other) actually born in interaction.
Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

Aim: To evaluate the association of environmental risk factors, particularly paternal and maternal age, with gender and type of oral cleft in newborn with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Methods: This study included 1,346 children with NSCL/P of two Brazilian Services for treatment of craniofacial deformities. Parental ages were classified into the following groups: maternal age <35, 36-39, and ≥40 years; paternal age <39 and ≥40 years. The data was analyzed with chi-square test and multinomial logistic regression analysis. The odds ratios were estimated with a 95% confidence interval. Results: Of the 1,346 children included in this study, CLP was the type of NSCL/P with highest prevalence, followed by, respectively, CL and CP. There was a greater occurrence of NSCL/P in males compared to females (55.8% versus 44.2%). CLP was more common in men, while the CL and CP were more prevalent in women (p=0.000). No association between maternal age and clefts was observed (p=0.747). However, there was evidence of association between father’s aged ≥40 years old and NSCL/P (p=0.031). When patients with CP were analyzed separately, no association between the father’s age and the child’s gender (p=0.728) was observed, i.e. the female gender prevails among patients with CP, regardless of the father’s age. Conclusions: This study showed that there were differences in the distribution of the non-syndromic cleft lip and/or palate and the gender, and fathers aged ≥40 years old may have increased risk of oral cleft. Further studies involving different populations are needed for a better understanding of the effect of maternal and paternal ages as a risk factor for the occurrence of oral clefts.
Management implications of moving from a traditional structured systems development methodology to object-orientation

As software application systems become larger and more complex, many software employers and managers believe that the key to sustaining its competitive advantage in the computing technology market lies in its software engineering capabilities. Software crisis situation seems to be a common occurrence in the software development environment as systems become larger and more complex. Object Orientation (0 0 ) has been proposed as a viable alternative to traditional approach (i.e., structured techniques), an approach that many hope will solve the current software crisis. 0 0 is a new paradigm, and it requires new types of knowledge, new specialists, and significant changes in the mindset, an entirely different way of thinking, representing and solving a problem. The transition of moving toward the 0 0 from the traditional approach may involve a high risk of failure if the managers do not understand the nature of paradigm shifts and do not anticipate the future. The problem of moving to 0 0 has become very important. An understanding of potential problems from migrating to the new paradigm helps managers make a smoother paradigm shift. The implications and challenges of the 0 0 paradigm are presented. The study suggests that Object-Oriented System Development (OOSD) requires more discipline, management and training than traditional software development does. Education and experience are keys for the success of any OOSD project.