Miracle-dz/UniFAR-FTUs huggingface dataset:
Baseline Characteristics and Early Blood Pressure Control in the CONVINCE Trial

Blood pressure (BP) control rates around the world are suboptimal. Part 2 of the National Health and Nutrition Educational Survey (NHANES) III indicates that only 27.4% of hypertensive Americans aged 18 to 74 years have a BP of <140/90 mm Hg. We wanted to assess BP control during the first 2 years and to describe the baseline characteristics of patients enrolled in the Controlled ONset Verapamil INvestigation of Cardiovascular Endpoints (CONVINCE) Study, an international clinical trial that compares outcomes in hypertensive patients randomized to initial treatment with either controlled-onset extended-release verapamil or the investigator’s choice of atenolol or hydrochlorothiazide. At randomization, BP was <140/90 mm Hg in only 20.3% of the 16 602 subjects (average±SD age 65.6±7.4 years; 56% women, 84% white/7% black/7% Hispanic). The average BP at enrollment was 148/85 mm Hg for patients taking BP medications (n=13 879) and 161/94 mm Hg for previously untreated patients (n=2723). After medication titration, with a transtelephonic computer that recommended an increase in the dose or number of antihypertensive agents whenever the BP was 140/90 mm Hg, 84.8% of the subjects attained the goal BP. During 2 years of treatment, BP control was maintained in 67% to 69% of the subjects (69% to 71% for systolic BP of <140 mm Hg and 90% for diastolic BP of <90 mm Hg). These data suggest that the control of systolic BP is more difficult than the control of diastolic BP. The US national goal of having 50% of hypertensives with a BP of <140/90 mm Hg may be achievable if a forced titration strategy is used. Interested investigators, free care and medications, and well-educated subjects may make the attainment of such a goal easier in the CONVINCE study than in the general population.
A 5ns fast write multi-level non-volatile 1 K bits RRAM memory with advance write scheme

A 1-Kb HfO2 based RRAM for high speed nonvolatile memory application is proposed. With this chip, a high speed write characteristic in the RRAM cell can be achieved. The present circuit design includes a 1T1R RRAM (1 transistor/1 resistive memory) cell and a voltage write circuit, which limit the current through the memory cell. The random write time at VDD = 3.3V is as fast as 5 ns in the RRAM, which were fabricated with a 0.18 µm TSMC process.
分子靶向药物应用于非小细胞肺癌维持治疗的研究进展

Radiology is the primary lung cancer screening technique. Whether the mortality rate of lung cancer could be markedly reduce by radiological screening was still unknown to us. It was suggested that high-risk individuals should take regular radiological examinations to detect early lung cancers, followed by suitable treatment. In this review, we compared the values of different radiological methods in lung cancer screening.
Inhibition of the contraction of the ductus arteriosus to oxygen by 1‐aminobenzotriazole, a mechanism‐based inactivator of cytochrome P450

1 We have proposed that contractile tension of the ductus arteriosus is sustained by a cytochrome P450‐linked mechanism acting as a limiting step in the synthesis of endothelin‐1 (ET‐1). In the present study, we have used the isolated ductus from near‐term foetal lambs and guinea‐pigs to investigate the effect on both muscle tone and ET‐1 formation of 1‐aminobenzotriazole (ABT), a suicide substrate for mono‐oxygenase reactions. 2 ABT relaxed the lamb ductus at rest (2.5% O2) and during the oxygen contraction (15 to 95% O2). The effect was seen at 40 μ, and at 0.8 mM active tone was almost completely abolished. ABT (1 mM) also reversed the oxygen contraction in the guinea‐pig ductus. 3 In the lamb ductus, the ABT response was not affected by removal of the endothelium or by treatment with 2.8 μ indomethacin (at 2.5% O2) and the ensuing contraction. 4 At both low and high concentration, ABT relaxed marginally, or not at all, the potassium‐contracted (55 mM) ductus from either species. 5 ET‐1 release from either the intact or endothelium‐denuded lamb ductus tended to decrease in the presence of ABT (1 mM), whilst during the same treatment cyclic GMP content of the tissue remained unchanged. 6 We conclude that ABT relaxation is due to suppression of a contractile mechanism and not to activation of prostaglandin‐ and NO‐mediated relaxing mechanisms. This contractile mechanism has a cytochrome P450‐based mono‐oxygenase reaction as a key component.
New-onset bipolar disorder in late life: a case of mistaken identity.

A 60-year-old, right-handed, previously successful and psychiatrically healthy businessman was brought by his family to a university hospital neuropsychiatry service for consultation regarding behavioral and personality changes. When he was age 55 years, his customarily excellent financial and social judgment began to decline. Over the next 4 years, his attention to personal hygiene deteriorated, his business decisions became financially and ethically unsound, his range of social interests narrowed dramatically, and he developed an insatiable “sweet tooth. ” In the year preceding the consultation, his ability to maintain sleep diminished, he began spending money recklessly and impulsively and became unable to appreciate the feelings and concerns of others, and his speech and behavior took on a perseverative quality. Concurrently, he developed unprovoked, brief, frequent, and excessively intense episodes of tearfulness and laughing. These episodes lasted minutes at most, after which he would return to his usual euthymic emotional state. One month before the neuropsychiatric consultation, he had received a diagnosis of late-onset bipolar disorder and had begun treatment with lithium carbonate. When his serum lithium level reached the therapeutic range, his cognitive, behavioral, and motor function declined precipitously, prompting the consultation for a second diagnostic opinion. Is this patient’s presentation consistent with late-onset bipolar disorder? What assessments are needed to clarify his diagnosis?
A data model for exploration of temporal virtual reality geographic information systems

Geographic information systems deal with the exploration, analysis, and presentation of geo-referenced data. Virtual reality is a type of human-computer interface that comes close to the way people perceive information in the real world. Thus, virtual reality environments become the natural paradigm for extending and enhancing the presentational and exploratory capability of GIS applications in both the spatial and temporal domains. The main motivation of this thesis is the lack of a framework that properly supports the exploration of geographic information in a multi-dimensional and multi-sensorial environment (i.e., temporal virtual reality geographic information systems). This thesis introduces a model for virtual exploration of animations. Virtual exploration of animations is a framework composed of abstract data types and a user interface that allow non-expert users to control, manipulate, analyze, and present objects' behaviors in a virtual-reality environment. In the model for virtual exploration of animations, the manipulation of the dynamic environment is accomplished through a set of operations performed over abstractions that represent temporal characteristics of actions. An important feature of the model is that the temporal information is treated as first-class entities and not as a mere attribute of action's representations. Therefore, entities of the temporal model have their own built-in functionality and are able to represent complex temporal structures. In an environment designed for the manipulation of the temporal characteristics of actions, the knowledge of relationships among objects' behaviors plays a significant role in the model. This information comes from the knowledge base of the application domain and is represented in the model through constraints among entities of the temporal model. Such constraints vary from simply relating the end points of two intervals to a complex mechanism that takes into account all relations between sequences of intervals of cyclic behaviors. The fact that the exploration of the information takes place in a virtual reality environment imposes new requirements on the animation model. This thesis introduces a new classification of objects in a VR environment and describes the associated semantics of each element in the taxonomy. These semantics are used to direct the way an object interacts with an observer and with other objects in the environment.
Antibodies recognizing CD24 LAP epitope on human T cells enhance CD28 and IL‐2 T cell proliferation

Membrane expression of the CD24 molecule on activated T lymphocytes is not elucidated fully. We previously described the intracellular and cell‐surface expression of the CD24 sialic acid‐dependent epitope(s) on phytohemagglutinin‐activated peripheral blood mononuclear cells. However, the CD24 core protein was not detected previously on human T cells. This study reinvestigated the expression and role of CD24 in T cell subsets. We analyzed binding of anti‐CD24 monoclonal antibodies (mAbs) to sialic and leucine‐alanine‐proline (LAP) epitopes in resting and activated, normal T lymphocytes. CD24 LAP and CD24 sialic epitopes were detected on activated CD4‐ and CD8‐positive cells. Although expression of CD24 sialic epitopes remained stably expressed in interleukin (IL)‐2‐dependent cultures, T cell expression of the LAP epitope was transient. Anti‐LAP antibodies strongly enhanced the response of T cells to a combination of anti‐CD3/CD28 mAbs and enhanced proliferative response induced by recombinant IL‐2. We found similarities in the tissue distribution and function of the human CD24LAP molecule and the murine, heat‐stable antigen, which suggests that CD24 might function as a signaling molecule on human T cells.
Some comments on the statistical methods used in linkage investigations.

NEWTON MORTON has shown in a series of papers (Morton 1955, 1957, Steinberg and Morton 1.956) that sequential methods for the detection of linkage have many advantages. They are appreciably simpler and more efficient than most of the methods previously used, and are convenient in practice. Nevertheless their use raises important questions of principle. It seems to me that the use of a Wald sequential stop-rule, as advocated by Morton, is not appropriate in linkage work and confers no advantage: on the other hand Bayes' Theorem can be quite easily applied, using Morton's own results, and gives a more satisfactory answer from both the theoretical and practical points of view. (It may not in fact give a very different answer to that given by the sequential test: all the same it seems worth discussing the issues of principle involved.)
Contribution au développement d'un prototype de superviseur de performance optique

L'evolution de la nouvelle generation des reseaux optiques vers les reseaux transparents va apporter une flexibilite supplementaire de la couche physique avec l'adjonction de composants tels que les ROADM (Reconfigurable Add-Drop Multiplexer) et les brasseurs tout optiques. Toutefois, la transparence implique la suppression de nombreuses conversions optique/electrique lors de la transmission d? un canal. Il devient alors plus difficile de controler directement la qualite des signaux numeriques en des points intermediaires du trajet. Pour pallier a ce probleme, une solution consiste a recourir aux techniques de surveillance des performances optiques (OPM : Optical Performance Monitoring) qui permettent d'evaluer les caracteristiques des canaux optiques en mesurant certains de leurs parametres physiques sans mesurer la qualite des signaux numeriques transmis par ces canaux. On se focalisera essentiellement sur la mesure du rapport signal a bruit optique (OSNR : Optical Signal-to-Noise Ratio) qui est un parametre cle dans l'estimation du taux d'erreur binaire. L? OSNR est mesure de maniere classique par une methode hors-bande basee sur la methode d'interpolation lineaire ou le bruit au sein du canal est estime a partir du niveau de bruit present de part et d'autre du canal. Cependant, cette methode presente des limitations dans le cas de reseaux de nouvelle generation a base de ROADM ou les canaux sont etroitement filtres. Pour pallier a ce probleme, une solution est d'effectuer une mesure intra-bande de l'OSNR qui consiste a evaluer le bruit au sein meme du canal en appliquant une technique d'annulation de polarisation a un prototype OPM qui a ete concu au laboratoire.
The calpain system.

The calpain system originally comprised three molecules: two Ca2+-dependent proteases, mu-calpain and m-calpain, and a third polypeptide, calpastatin, whose only known function is to inhibit the two calpains. Both mu- and m-calpain are heterodimers containing an identical 28-kDa subunit and an 80-kDa subunit that shares 55-65% sequence homology between the two proteases. The crystallographic structure of m-calpain reveals six "domains" in the 80-kDa subunit: 1). a 19-amino acid NH2-terminal sequence; 2). and 3). two domains that constitute the active site, IIa and IIb; 4). domain III; 5). an 18-amino acid extended sequence linking domain III to domain IV; and 6). domain IV, which resembles the penta EF-hand family of polypeptides. The single calpastatin gene can produce eight or more calpastatin polypeptides ranging from 17 to 85 kDa by use of different promoters and alternative splicing events. The physiological significance of these different calpastatins is unclear, although all bind to three different places on the calpain molecule; binding to at least two of the sites is Ca2+ dependent. Since 1989, cDNA cloning has identified 12 additional mRNAs in mammals that encode polypeptides homologous to domains IIa and IIb of the 80-kDa subunit of mu- and m-calpain, and calpain-like mRNAs have been identified in other organisms. The molecules encoded by these mRNAs have not been isolated, so little is known about their properties. How calpain activity is regulated in cells is still unclear, but the calpains ostensibly participate in a variety of cellular processes including remodeling of cytoskeletal/membrane attachments, different signal transduction pathways, and apoptosis. Deregulated calpain activity following loss of Ca2+ homeostasis results in tissue damage in response to events such as myocardial infarcts, stroke, and brain trauma.
Performing repentance: (in)sincerity in prodigal son drama and the Henry IVs

The parable of the prodigal son is the most popular repentance narrative in early modern drama, yet the authenticity of these prodigals’ repentances is frequently disputed. The truly repentant prodigal and posturing sinner are functionally identical on the early modern stage, and the parable was so renowned that the prodigal's repentance and forgiveness could not only be predicted, but expected and engineered. This essay compares prodigals’ repentances across Eastward Ho, The London Prodigal, 2 If You Know Not Me You Know Nobody, and the Henry IVs. It argues that these plays exhibit discomfort with the outward display of repentance, the irrelevance of sincerity, and the viability of the parable as a repentance narrative. While some of these repentances have been discussed in isolation, their comparison allows for the examination of ambiguous repentances not as isolated incidents but a discernible trend in early modern culture, born from anxieties regarding the indistinguishability of feigned and ‘true’ performances of inward spiritual change. The authenticity of repentance, it emerges, cannot be determined, but repentance also need not be sincere to be accepted by a plays’ community. The authenticity of repentance proves not only impossible to identify, but ultimately irrelevant to these plays’ social worlds.
Race and Microaggression in Nursing Knowledge Development

Race is a social environmental element in many nursing knowledge contexts. We explore how race and racism have been conceptualized in nursing research and theory, situating these issues in the debate between Critical Race Theory and postracialism. Contemporarily, racism is more subtle than overt. Subtle racism takes the form of microaggressions in everyday discourse and practices by whites toward African Americans. This occurs with little to no awareness on the part of whites. Using this concept, practice and education are explored. We hold that microaggressions contribute to stress for the target person, which may partly account for racial health disparities.
Lung dose-volume parameters and the risk of pneumonitis for patients treated with accelerated partial-breast irradiation using three-dimensional conformal radiotherapy.

PURPOSE There are no data on how complication rates after accelerated partial-breast irradiation delivered by three-dimensional conformal radiotherapy are affected by treatment technique. We therefore examined the risk of pneumonitis in relation to lung dose-volume parameters. PATIENTS AND METHODS Our prospective dose-escalation trial enrolled 198 treated patients from 2003 to 2007. Patients received 32 or 36 Gy in 4-Gy fractions, given twice daily: 29 (14%) were treated with pure photons; 149 (77%) with mixed photons and electrons; and 20 (10%) with protons. RESULTS There were four cases of pneumonitis at 4, 4, 7, and 9 months after treatment. All were in the 36-Gy cohort and were treated with pure photons. The risk of pneumonitis for the two cohorts combined was: 17% (four of 24) for an ipsilateral lung volume (ILV) receiving 20 Gy or higher (ILV, 20 Gy) of 3% or higher (P = .0002 for comparison to ILV 20 Gy < 3%, Fisher's exact test); 20% (four of 20) for an ILV 10 Gy of 10% or higher (P = .0001); and 15% (four of 26) for an ILV 5 Gy of 20% or higher (P = .0002). CONCLUSION The risk of pneumonitis appeared related to the ILV treated. This volume can be reduced by using mixed photons and electron when possible. We recommend that the ILV 20 Gy should be lower than 3%, the ILV 10 Gy lower than 10%, and the ILV 5 Gy lower than 20% when purely coplanar techniques are used.
A natural language system for retrieval of captioned images

ANVIL is an information retrieval system using natural language processing techniques, intended for retrieval of captioned images. It extracts dependency structures from the image captions and user queries, and then applies a high accuracy matching algorithm which recursively explores the dependency structures to determine their similarity. A further algorithm allows additional contextual information to be extracted following a successful match, with the intention of helping users understand and organise the retrieval results. ANVIL was developed to high engineering standards, and as well as looking at the research aspects of the system, we also look at some of the design and development issues. English and Japanese versions of the system have been developed.
IEEE 802.16 metropolitan area network with SDMA enhancement

Broadband access is the key driver of the telecommunications industry today. Customers all around the world demand this service to surf the World Wide Web (WWW) and to communicate by email. Furthermore, the classical Internet undergoes a shift towards a collaborative (second generation) Internet of people. The WWW is used as a platform to establish social networks and to share self-generated content. People download and upload rich multimedia content. They want to be connected. In metropolitan areas, fixed Broadband Wireless Access (BWA) offers a costeffective alternative to wired broadband access technology such as Digital Subscriber Line (DSL) and cable modem. In rural areas, fixed BWA can bridge the digital divide by bringing broadband services to remote places. Finally, BWA technology provides market potential for portable and mobile broadband services. IEEE 802.16 (or WiMAX) is a promising radio access technology that performs similar to wired access systems and covers large geographic regions. The key feature to reach that goal is the integration of multi antenna techniques. Beamforming is the most promising MIMO technique since it allows for both, increased system capacity and extended cell coverage. The thesis describes the developed comprehensive system concept to fully integrate Space Division Multiple Access (SDMA) technology into the IEEE 802.16 system. SDMA affects a large portion of the WiMAX system. Multiple antennas are required in the PHY layer to form adaptive patterns. Through the newly specified PHY Service Access Point (SAP) the enhanced PHY layer offers its beamforming services to the Medium Access Control (MAC) entities. The extended MAC protocol controls the additional spatial dimension. Multiple access based on Time Division Multiple Access (TDMA) and SDMA need to be coordinated. Besides the protocol, MAC algorithms are affected by beamforming and SDMA. The hierarchical TD-SD-OFDM scheduling algorithm proposed in this work optimizes resource allocation while observing strict real-time constraints. For multi-hop transmission a MAC extension is specified and evaluated. By leveraging SDMA on the feeder link, the proposed MAC frame structure strengthens the radio link, which is the bottleneck in most multi-hop systems. On the access link,
Design procedure for low cost, low mass, direct drive, in-wheel motor drivetrains for electric and hybrid vehicles

Direct drive, in-wheel motors are ideal for electric and hybrid vehicles because the packaging of the drivetrain is so simple, because drivetrain losses are eliminated, and because individual wheel control improves handling and safety. In applications where cost is not a constraint, e.g. solar car racing, direct drive, in-wheel motors are the norm. In-wheel motors are also regularly demonstrated in concept vehicles. However, in-wheel motors are not used for production vehicles because of their high cost and high-unsprung mass. This paper describes a project that addresses these issues through the use of a novel, multiple-airgap, axial-flux, switched-reluctance motor with optimized packaging and low cost electronics. The emphasis of the paper is on how to design the system as a whole.
Therapy of acute kidney injury in the perioperative setting

Purpose of review The current review analyzes the current pharmacologic approaches in cardiac surgery–associated acute kidney injury and renal replacement/support therapies. Recent findings Hemodynamic management and promising therapies, including atrial natriuretic peptide, calcium sensitizer inodilators, and mesenchymal stem cells have been discussed. Encouraging results from pre-emptive renal replacement therapies have been also addressed. Summary Cardiac surgery is responsible for the highest risk of renal dysfunction with respect to other surgical settings. A number of different and coacting insults, including toxins, renal hypoperfusion, ischemia–reperfusion injury, and systemic inflammation, are leading causes of this frequent complication. Intense research is ongoing on the treatment of established cardiac surgery–associated acute kidney injury and, in this view, a holistic approach including preoperative data, risk stratification, prevention, timely diagnosis, and aggressive intervention can limit the burdening consequences of renal dysfunction in these patients. Although no specific pharmacologic and nonpharmacologic strategy can be currently recommended outside clinical research, the prompt identification of renal dysfunction and the application of multimodal treatments are fundamental aspects. Right ventricular dysfunction and increased central venous pressure, frequently affecting cardiac surgery patients, potentially lead to congestive renal dysfunction. Hemodynamic management covers a central role in these cases.