Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding noise measurements in MOSFETs: the role of traps structural relaxation

The presented theoretical analysis of random telegraph signal (RTS) and 1/f noise data provides consistent interpretation of the measurement results allowing trap characteristics to be extracted and the atomic structure of oxide traps to be identified. We emphasize the critical role of the lattice structural relaxation associated with charge trapping/detrapping, which represents one of the major factors controlling electron capture/emission times.
An Interactive Java Statistical Image Segmentation System: GemIdent.

Supervised learning can be used to segment/identify regions of interest in images using both color and morphological information. A novel object identification algorithm was developed in Java to locate immune and cancer cells in images of immunohistochemically-stained lymph node tissue from a recent study published by Kohrt et al. (2005). The algorithms are also showing promise in other domains. The success of the method depends heavily on the use of color, the relative homogeneity of object appearance and on interactivity. As is often the case in segmentation, an algorithm specifically tailored to the application works better than using broader methods that work passably well on any problem. Our main innovation is the interactive feature extraction from color images. We also enable the user to improve the classification with an interactive visualization system. This is then coupled with the statistical learning algorithms and intensive feedback from the user over many classification-correction iterations, resulting in a highly accurate and user-friendly solution. The system ultimately provides the locations of every cell recognized in the entire tissue in a text file tailored to be easily imported into R (Ihaka and Gentleman 1996; R Development Core Team 2009) for further statistical analyses. This data is invaluable in the study of spatial and multidimensional relationships between cell populations and tumor structure. This system is available at http://www.GemIdent. com/ together with three demonstration videos and a manual.
Les Pinceaux d’Or : une expérience d’hygiène mentale auprès d’aînés en besoins psychosociaux

Vieillir en sante exige l’ajustement d’un developpement personnel a poursuivre. Plusieurs recherches, notamment Cohen (2007), ont demontre l’impact positif d’activites artistiques pour les personnes âgees. A Quebec est ne en 2006 un organisme sans but lucratif (OSBL), Les Pinceaux d’Or. Sa mission est de valoriser les aines demunis a travers une experience positive d’apprentissage de la peinture. L’organisme intervient dans des Centres hospitaliers de soins psychiatriques (CHSP), Habitations a loyer modique (HLM) et Centres de jours aupres de personnes referees par les Centres locaux des services communautaires (CLSC) ou les organismes communautaires. L’unique condition de participation : etre une personne âgee capable de tenir un pinceau, experience nouvelle pour la majorite. L’âge moyen est 81 ans, quatre furent centenaires (101 a 109 ans)Le participant utilise ses souvenirs pour personnaliser le sujet de sa toile, occasion d’echanges emotionnels positifs avec les autres, sans compter le plaisir de decouvrir qu’il peut apprendre encore. L’article decrit l’experience et presente les resultats d’une etude qualitative du Centre d’excellence sur le vieillissement de Quebec (CEVQ). Cette activite illustre une forme de contribution au stade integrite decrite par Erikson et les elements de la philosophie du retablissement :un projet de vie ou revisiter son passe pour le tableau devient l’occasion de l’espoir, celui de laisser une trace pour la famille ;empowerment, ou le sage-artiste decouvre qu’il peut apprendre encore et reduit son autostigmatisation negative ;l’inclusion sociale par les relations creees entre les participants ;et enfin la citoyennete a travers certaines initiatives (developpement social de trois HLM ; cartes et calendriers avec peintres identifies a Wendake, cartes dont le profit des ventes est verse a une fondation et que le Conseil de bande utilise pour certaines communications).
An RNS modular multiplication algorithm

An RNS implementation of Barrett's modular multiplication algorithm is presented in this paper. Existing algorithms for RNS modular multiplication employ Montgomery's technique. An algorithmic comparison with such state-of-the-art solutions shows that the proposed algorithm may reduce the total number of modular multiplications per RNS modular multiplication by 33%-50%.
Promoter hypermethylation of methyl guanine methyl transferase in lung cancer patients of Kashmir valley

Context: MGMT , is a DNA repair protein involved in removing the mutagenic and cytotoxic adducts from O 6 -guanine in DNA, which otherwise can lead to the mutation, primarily due to the tendency of O 6 -methylguanine to pair with thymine during replication, resulting in the conversion of GC to AT pairs, if left unrepaired due to epigenetic silencing of its promoter. Aims: To study the status of MGMT in Kashmiri lung cancer patients Materials and Methods: In this study we analyzed the promoter status of this gene in 50 lung cancer patients using methylation specific-PCR and confirmed by restriction digestion. Results: The promoter was found to be methylated in 52% of the cases, more in male patients (54.2%) than in female patients (46.6%). When stratified according to smoking status, current smokers showed a strong association with methylation (OR = 6.0, P = 0.005) than former and never smokers. We also compared the promoter methylation of the MGMT gene with pesticide exposure, and found that patients with pesticide exposure had statistically significant (OR = 7.7 and P = 0.003) association with promoter methylation. Conclusions: Our results indicate that MGMT promoter methylation is associated with smoking exposure and there appears to be an association of MGMT promoter methylation with pesticide exposure in Kashmiri lung cancer patients.
Role of P30 in Replication and Spread of TMV

The P30 movement protein (MP) of tobacco mosaic virus is essential for distribution of sites of replication within infected cells and for cell–cell spread of infection. MP is an integral membrane protein and in early and mid‐stages of infection causes severe disruption of the cortical endoplasmic reticulum (ER). MP also associates with microtubules, and in late stages is targeted for degradation by the 26S proteosome. During these stages, the ER regains its normal pre‐infection configuration. Viral RNA is associated with ER and microtubules in the presence of MP. The MP is phosphorylated and mutation of the phosphorylated amino acid reduced association of MP with the ER, plasmodesmata, and microtubules, and altered the stability of the MP. The nature of the association of MP with vRNA and ER and microtubules, and the role of phosphorylation of MP in each of these functions, if any, remains to be determined.
Copper and animal health (Importance, maternal fetal, immunity and DNA relationship, deficiency and toxicity) -

Copper is an important trace element that plays a very important role in the biochemistry of all living organisms and affects enzymes activity as a cofactor or as a fundamental structure of many metalloenzymes as superoxide dismutase, ceruloplasmin, lysyl oxidase, cytochrome oxidase and tyrosinase. Therefore copper is essential for cellular respiration, free radical defence, neurotransmitter function connective and tissue biosynthesis. Excessive copper accumulation is toxic in all species as it leads to hepatic cirrhosis, hemolytic anemia and degeneration of basal ganglia. The aim of this review is to give a view on the health issue surrounding copper and animal health including many interested points about copper and fetal maternal relationship, the role of copper in the different body system and the effect of its deficiency and toxicity, as well as focusing on the relationship of copper with other trace elements, metalloenzymes, immunity and DNA.
The involvement of vasopressin in the renal actions of atrial natriuretic peptide in conscious fluid-balanced rats.

The renal and endocrine actions of atrial natriuretic peptide (ANP) administered at a rate to induce plasma concentrations within the physiological range have been re-examined in conscious rats in which body fluid volume was maintained by infusion of replacement fluid at a rate to match spontaneous urine losses (servo-controlled replacement) throughout experimentation. The involvement of vasopressin in the actions of ANP was assessed by comparing the responses induced in Brattleboro (DI) and Long-Evans (LE) rats. A rate of ANP administration inducing a less than twofold increment in circulating ANP concentration evoked a small but significant diuresis and natriuresis. In contrast to previous studies during which body fluid balance had not been maintained and the response to ANP was transient, renal responses were rapid in onset and sustained over the period of hormone administration. The change in renal excretion occurred without concomitant changes in mean arterial blood pressure, haematocrit or glomerular filtration rate, and without consistent alterations in the circulating concentrations of angiotensin II, vasopressin, aldosterone or corticosterone. Furthermore, although small differences between the two strains in the character of the response could be demonstrated, the evoked response was of similar magnitude in vasopressin-replete and -deficient animals. In summary, in conscious rats in which body fluid volume was maintained, the profile of the diuretic and natriuretic responses evoked by low-rate ANP administration was different from that previously observed in anaesthetized and/or constantly infused preparations; being rapid in onset and sustained. (ABSTRACT TRUNCATED AT 250 WORDS)
A kind of covert channel analysis method based on trusted pipeline

The covert channel analysis has been the focus of high-level secure operating system research. Firstly, the concept and analysis methods of covert channel are described. Secondly, combined with the classic non-interference model of information flow, concept of a trusted pipeline has been applied to eliminate storage covert channel. Finally, a storage covert channel of object existence is analyzed, and the effect of trusted pipeline in eliminating the covert channel is shown.
Distribution procedures in Brazil: Rules for grid connection

The connection of generating sources in the distribution systems is on the increase worldwide. If on one hand this practice brings well-known benefits for the system, on the other, there are several institutional barriers that make difficult its feasibility. This way, the Brazilian National Electric Energy Agency (ANEEL) has developed the so called “Distribution Procedures”, which is a set of rules to govern the distribution energy systems access. This paper presents the policy observed during its development and the expected results with its implementation.
2W wideband microwave PA design for 824-2170 MHz band using Normalized Gain Function method

In this work, we present the design of a 2W linear wideband microwave PA (power amplifier) targeted to operate in 824-2170 MHz mobile frequency range covering GSM850, EGSM, DCS, PCS and WCDMA. The design is basically based on the NGF (Normalized Gain Function) method which is very recently introduced into the literature. NGF is defined as the ratio of T and |S21|2, i.e. TNGF=T/|S21|2, shape of the gain function of the amplifier to be designed and the shape of the transistor forward gain function, respectively. Synthesis of input/output matching networks (IMN/OMN) of the amplifier requires target gain functions, which are mathematically generated in terms of TNGF. The particular transistor used in the design is FP31QF, a 2W HFET from TriQuint Semiconductor. Theoretical PA performance obtained in Matlab is shown to be in a very high agreement with the simulated performance in MWO (Microwave Office) of AWR Inc.
Aggregating Phenotype in Lactobacillus crispatus Determines Intestinal Colonization and TLR2 and TLR4 Modulation in Murine Colonic Mucosa

ABSTRACT The colonic microbiota is a major modulator of the mucosal immune system; therefore, its manipulation through supplementation with probiotics may significantly affect the host's immune responses. Since different probiotics seem to exert various effects in vivo, we tested the relevance of the autoaggregation phenotype on the intestinal persistence of lactobacilli and their ability to modulate the host's innate immune responses. After 14 days of diet supplementation, the aggregating strain Lactobacillus crispatus M247 but not aggregation-deficient isogenic mutant MU5 was recovered from the feces and colonic mucosa of mice. This observation was confirmed by strain-specific PCR amplification and by Lactobacillus-specific denaturing gradient gel electrophoresis analysis. Indeed, L. crispatus M247 increased Toll-like receptor 2 (TLR2) mRNA levels, while it reduced TLR4 mRNA and protein levels in the colonic mucosa, whereas MU5 was ineffective. In colonic epithelial cells (CMT-93 cells) L. crispatus M247 but not MU5 induced time-dependent extracellular signal-regulated kinase-1 (ERK1) tyrosine phosphorylation and TLR modulation, which were abolished in the presence of PD98059 (an ERK1 inhibitor). To assess the functional relevance of probiotic-induced TLR modulation, we determined the consequences of L. crispatus preexposure on TLR4 (lipopolysaccharide [LPS]) and TLR2 [Pam3Cys-Ser-(Lys)4] ligand-mediated effects in intestinal epithelial cells. Preexposure to L. crispatus M247 blunted LPS-induced interleukin-6 (IL-6) release and inhibition of CMT-93 migration over a wound edge, whereas it enhanced TLR2-mediated IL-10 up-regulation. In summary, the aggregation phenotype is required for L. crispatus persistence in the colon and for modulation of TLR2/TLR4 expression through an ERK-dependent pathway. We speculate that the aggregation phenotype in L. crispatus M247 is required to temper epithelial cell responsiveness to bacterial endotoxins, which thus affects the evolution of intestinal inflammatory processes.
Impact of a prophylactic combination of dexamethasone–ondansetron on postoperative nausea and vomiting in obese adult patients undergoing laparoscopic sleeve gastrectomy during closed-loop propofol–remifentanil anaesthesia: A randomised double-blind placebo-controlled study

BACKGROUND In obese patients, the incidence of postoperative nausea and vomiting (PONV) following sleeve gastrectomy under titration of total intravenous anaesthesia (TIVA) and the relevance of risk factors to indicate prophylaxis is unknown. OBJECTIVES The hypothesis was that after automated TIVA, prophylaxis reduces PONV following laparoscopic sleeve gastrectomy. Our objective was to determine the incidence of PONV and evaluate the efficacy of dexamethasone and ondansetron as prophylaxis when automated intravenous anaesthesia is employed. DESIGN A randomised, placebo-controlled, single-centre, double-blinded study. SETTING Secondary care centre in New Caledonia from June 2013 to January 2014. PATIENTS A total of 122 patients were randomised and 117 (92 women) were included in the analysis (58 in the prophylaxis group and 59 in the placebo group). Eligibility criteria included at least two of the known risk factors for PONV: female sex, nonsmoking status, prior history of PONV or motion sickness and expected postoperative opioid analgesia. Exclusion criteria included disorders limiting the use of the bispectral index. INTERVENTIONS All patients received propofol and remifentanil controlled by the same automated system during induction and maintenance of general anaesthesia. The controller modifies the calculated effect-site concentrations according to bispectral index values. Patients received either intravenous dexamethasone 4 mg after tracheal intubation and ondansetron 4 mg during skin closure, or placebo. MAIN OUTCOME MEASURES The primary endpoint was the cumulative incidences of 24-h PONV and severe PONV (vomiting or nausea with a score of ≥4 on an 11-point verbal rating scale). Data are presented as percentage (95% confidence interval). RESULTS PONV in the first 24 h occurred in 45 (34 to 60)% of patients who received prophylaxis and 54 (41 to 67)% in the placebo group (P = 0.35). The numbers of patients who suffered severe PONV [19 (10 to 32)% in the prophylaxis group vs. 20 (11 to 33)%, P = 1, in the placebo group] and who required rescue antiemetic drugs [55 (41 to 68) vs. 63 (49 to 75)%, P = 0.46] were similar between the groups. CONCLUSION The combination of dexamethasone and ondansetron was not effective in preventing PONV or severe PONV in obese patients undergoing laparoscopic sleeve gastrectomy after TIVA. TRIAL REGISTRATION Clinicaltrials.gov identifier: NCT01876290.
THz characterization of multi-walled carbon nanotube paper

In this paper we have characterized the THz properties of a promising new material, MWNTs in a paper format. Both the transmission and reflection responses of the sample are measured using a TDS. The permittivity and permeability of the MWNT paper are extracted simultaneously. The advantage of this characterization method over other reported TDS measurements is that the non-magnetic assumption does not need to be imposed. The errors on n caused by the inappropriate assumption have been illustrated.
Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL+ B-Lineage Acute Lymphoblastic Leukemia

Purpose: BCR-ABL+ B-ALL leukemic cells are highly dependent on the expression of endogenous antiapoptotic MCL-1 to promote viability and are resistant to BH3-mimetic agents such as navitoclax (ABT-263) that target BCL-2, BCL-XL, and BCL-W. However, the survival of most normal blood cells and other cell types is also dependent on Mcl-1. Despite the requirement for MCL-1 in these cell types, initial reports of MCL-1–specific BH3-mimetics have not described any overt toxicities associated with single-agent use, but these agents are still early in clinical development. Therefore, we sought to identify approved drugs that could sensitize leukemic cells to ABT-263. Experimental Design: A screen identified dihydroartemisinin (DHA), a water-soluble metabolite of the antimalarial artemisinin. Using mouse and human leukemic cell lines, and primary patient-derived xenografts, the effect of DHA on survival was tested, and mechanistic studies were carried out to discover how DHA functions. We further tested in vitro and in vivo whether combining DHA with ABT-263 could enhance the response of leukemic cells to combination therapy. Results: DHA causes the downmodulation of MCL-1 expression by triggering a cellular stress response that represses translation. The repression of MCL-1 renders leukemic cells highly sensitive to synergistic cell death induced by ABT-263 in a mouse model of BCR-ABL+ B-ALL both in vitro and in vivo. Furthermore, DHA synergizes with ABT-263 in human Ph+ ALL cell lines, and primary patient-derived xenografts of Ph+ ALL in culture. Conclusions: Our findings suggest that combining DHA with ABT-263 can improve therapeutic response in BCR-ABL+ B-ALL. Clin Cancer Res; 23(24); 7558–68. ©2017 AACR.
Breastfeeding: Nature’s Safety Net

ABSTRACT Breastfeeding is a natural safety-net for the first few months in order to give the child a fairer start to life. The American Academy of Pediatric Dentistry recognizes the distinct nutritional advantages of human milk for infants and endorsed the position of the American Academy of Pediatrics on the promotion of breastfeeding. It therefore calls for increase in need to negotiate the roles and responsibilities of pediatric dentists to eliminate the existing gaps in preventive care and anticipatory guidance. The objective of this evidence-based review is to explore the beneficial roles of breastfeeding in orofacial growth and development and endorse the same through anticipatory guidance. How to cite this article: Agarwal M, Ghousia S, Konde S, Raj S. Breastfeeding: Nature’s Safety Net. Int J Clin Pediatr Dent 2012;5(1):49-53.
Data-Driven Methods for Predictive Maintenance of Industrial Equipment: A Survey

With the tremendous revival of artificial intelligence, predictive maintenance (PdM) based on data-driven methods has become the most effective solution to address smart manufacturing and industrial big data, especially for performing health perception (e.g., fault diagnosis and remaining life assessment). Moreover, because the existing PdM research is still in primary experimental stage, most works are conducted utilizing several open-datasets, and the combination with specific applications such as rotating machinery is especially rare. Hence, in this paper, we focus on data-driven methods for PdM, present a comprehensive survey on its applications, and attempt to provide graduate students, companies, and institutions with the preliminary understanding of the existing works recently published. Specifically, we first briefly introduce the PdM approach, illustrate our PdM scheme for automatic washing equipment, and demonstrate the challenges encountered when we conduct a PdM research. Second, we classify the specific industrial applications based on six algorithms of machine learning and deep learning (DL), and compare five performance metrics for each classification. Furthermore, the accuracy (a metric to evaluate the algorithm performance) of these PdM applications is analyzed in detail. There are some important conclusions: 1) the data used in the summarized literature are mostly from public datasets, such as case western reserve university (CWRU)/intelligent maintenance systems (IMS); and 2) in recent years, researchers seem to focus more on DL algorithms for PdM research. Finally, we summarize the common features regarding our surveyed PdM applications and discuss several potential directions.
Patient and equipment profile for wheelchair seating clinic provision

Abstract Purpose: To characterise the provision of wheelchair seating both pre- and post-clinical intervention and compare and contrast the two largest diagnostic groups. Method: The case notes of those attending a wheelchair seating clinic for adults over a defined period were reviewed retrospectively. A classification system was devised that delineates between the complexity and type of equipment to gain a better understanding of provision. Results: 146 patients were included; mean age 45 years (SD 16); 53.4% male. The two most prevalent primary medical diagnoses were cerebral palsy (CP) and multiple sclerosis (MS); 48.6% and 20.5%, respectively. The MS group, in comparison to the CP group, were significantly more likely to be older, new to seating provision, have been seen more recently, have a powered wheelchair, self-propel their manual wheelchair, have low rather than high complexity equipment and have their equipment changed following assessment. Conclusions: The equipment classification system will allow results from different studies to be readily compared. The results for those with CP and MS reflect the respective stable and progressive nature of these conditions. Referrals for those with MS should be prioritised. Wheelchair seating users with MS should be reassessed ∼18 months after provision. Implications for Rehabilitation A detailed classification of wheelchair seating equipment based on a recognised standard vocabulary, such as the one proposed, is required to gain a better understanding of provision. Wheelchair seating equipment budget and staffing levels should reflect the diagnostic make up of a service's patient population. Referrals for people with MS should be prioritised as their current wheelchair seating provision is more likely not to be meeting their needs. People with MS should have a clinical review 18 months after wheelchair seating provision.