Miracle-dz/UniFAR-FTUs huggingface dataset:
Preventing thymus involution in K5.Cyclin D1 transgenic mice sustains the naïve T cell compartment with age (LYM6P.716)

The thymus maintains T cell receptor (TCR) repertoire diversity through perpetual release of self-MHC restricted naive T cells. However, thymus involution during the aging process reduces naïve T cell output, leading to defective immune responsiveness to newly encountered antigens. We have shown that age-related thymus involution is prevented in mice expressing a keratin 5 promoter-driven Cyclin D1 (K5.D1) transgene in thymic epithelial cells (TECs). Sustained T cell output from K5.D1 thymi prevents the age-associated decline of naïve T cells in the periphery. We find that K5.D1 recent thymic emigrants (RTEs) undergo typical phenotypic maturation. Competitive adoptive transfer studies with K5.D1 and nontransgenic RTEs indicate that K5.D1 RTEs are incorporated into the peripheral T cell pool comparably to nontransgenic controls. In addition, functional studies show that K5.D1 peripheral T cells are responsive to anti-CD3 and anti-CD28 stimulation in vitro. Collectively, these data show that preventing thymus involution not only sustains T cell output, but also provides functionally competent RTEs during aging.
Preparation and In Vitro Characterization of Enoxaparin Nano-liposomes through Different Methods

Purpose: Enoxaparin has been widely used as a choice drug for treatment and prevention of different coagulation disorders. Orally administered enoxaparin encounters with gastrointestinal barrier because of its high water solubility, high molecular weight and significant negative charge. Since, the nano-liposomes has gained great interest for oral drug delivery, we decided to introduce the best protocol for preparing enoxaparin nano-liposomes through in vitro characterization. Methods: Nano-liposomes were prepared by ethanol injection, thin film hydration, and double emulsion/solvent evaporation methods. Size distribution, zeta potential, loading efficiencies, and in vitro drug release of nano-liposomes were also studied. Results: The mean vesicle size was obtained under 100 nm, and the zeta potential was highly negative through all preparation methods. Nano-liposomes prepared by double emulsion/ solvent evaporation (DE) technique could entrap more of this hydrophilic drug (43 ± 7.1 %), but through thin layer hydration (TL) and ethanol injection (EI) only 28.4± 3.2% and 17.3 ± 2.5% of drug could be loaded into synthesized carriers. Drug release from these carriers was also obtained 42.17±1.72%, 29.43±0.34% and 32.27±0.14%, in 24 hours for EI, TL, and DE methods, respectively. Conclusion: Here, we can introduce double emulsion/solvent evaporation method as an acceptable method for enoxaparin loading, although some toxicity and in-vivo tests are also necessary to fully understand the potential of this formulation.
THE INFLUENCE OF ACCOMPANYING COMPONENTS ON THE SORPTION OF MOLYBDATE ANIONS FROM AQUEOUS SOLUTIONS ON DISPERSED ICE SURFACE

The ice surface in the natural environments of the Earth may infl uence natural processes due to activity of the quasi-liquid fi lm that is formed on the surface of ice crystals. Sorption of molybdate anions (4⋅10–5 mol/L) from water solutions by the surface of dispersed ice particles is investigated. Supporting electrolyte is KCl (11.75 g/100 g of water) with addition of magnesium chloride with concentration not greater than 10–2 mol/L or ethanol with concentration not greater than 10–1 mol/L. The temperature is –5.1 °C. It has been demonstrated that increase of the content of magnesium chloride promotes sorption of molybdate anions. In contrast, increase of the content of alcohol lowers it. Diff erent eff ects of added substances may be due to the diff erent degrees of the infl uence of magnesium chloride ions and undissociated organic substance of the water structure in the quasi-liquid fi lm on the nature of dissolution of the other substances in it. The polar ethanol molecules can interact also with the surface of dispersed particles of ice.
A three tier system architecture design for factors affecting students' performance analysis in the Western region in Jeddah Universities

Objectives: To study different factors influencing the academic performance of students at Jeddah University in Saudi Arabia. Method: The study sample included 164 participants from university of Jeddah, composed of 127 females and 37 males. A survey was conducted by using a questionnaire containing the different factors that could affect academic performance of university students. The questionnaire data were collected and analyzed by using SPSS version 25 statistical program. Descriptive and correlation analysis was made. Three-tier architecture is developed to enable us to make better decisions faster by analyzing data, shared data sources that are centralized and can be stored on different types of servers. Findings: A significant correlation between gender (female) and students `scores with Spearman correlation coefficient (r) value of 0.33. A significant correlation was noted between friendship/peer relation and students' scores with (r) value of 0.80. Family education, family relation and friendship/peer relation play an important role in Saudi student academic performance indicating that student culture and environment affect academic performance significantly. Novelty: The multitier architecture on which presentation, application processing and data management functions are physically separated: ; we are able to update and use a large data without any application update.
Co-ordination action on Indoor Air Quality and Health Effects

The aim of the ENVIE project was to increase the understanding of the Europe-wide public health impacts of indoor air quality by identifying the most widespread and significant indoor causes for these health impacts and evaluating the existing and optional building and housing related policies for controlling them. It addressed in particular how indoor air quality might contribute to the observed rise in asthma and respiratory allergy, together with other acute and chronic health impacts. The intention was not to conduct new experimental or field research, but rather to build on the broad scientific experience and the wealth of accumulated literature from the domestic and international indoor air research projects as well as the EU, WHO, ISIAQ and CIB committees and expert groups during the past 20 years.
MASTERS THESIS Application of Hilbert-Huang transform in Bearing Fault Detection

Since the industrial revolution, machine of all sorts without doubt, have been, and still are the driving force of the world economy. Operating in harsh conditions, machines are prone to failure, which can incur financial losses, the degradation of the environment, and sometime human casualties. One of the main component of nearly all machines are bearings. Due to their geometrical characteristics, the latter facilitate rotation movements while being continuously subjected to large loads . Consequently, bearing failures represent more than 40% of machine breakdown. To mitigate bearing degradation, they are monitor in order to detect incipient faults as early as required. This is achieved by mounting sensors on strategics area surrounding a bearing, in order to measure, collect and analyze its vibration movement (vibration signal). The analysis processes for bearing fault detection in most industrial applications, rely on the Fourier transform. This is due to the fact that bearings faults occur at specific frequencies, called characteristic defect frequencies. A defect in a bearing will emit a periodic high frequency pulse as the bearing rotates. The frequency at which the pulse is emitted is the defect frequency. As a result, the core of bearing monitoring, is the early detection of onset of failure, expressed by the defect frequencies. The latter can be found in the frequency spectrum, derived by the Fourier transform. Bearings are in general mounted on machines comprising several components, each emitting its own vibration signal. This render the detection of defect frequencies in a bearing frequency spectrum challenging, due to interfering signals, and induced noise. Therefore, the frequency spectrum obtained directly from a bearing vibration signal, contains little diagnostic information. To circumvent the latter issue, a series of signal filtering operations and mathematical transformations are applied to a bearing vibration signal. The goal is to isolate and expose the relevant signal, that contains the defects frequencies. This process can be achieved through various methods. However, the most prevalent scheme is the so called high frequency resonance technique (HFRT). The HFRT removes or dump irrelevant signals, and extract relevant one, be-
Morbidity and mortality rates of Ganjam goats of Odisha in field condition

The present study deals with morbidity and mortality in Ganjam goats of Odisha due to different diseases and examining the effects of age, sex and season on morbidity and mortality rates using suitable statistical techniques. Morbidity and mortality data of 5819 Ganjam goats of 71 goat keepers from four clusters of Ganjam district were recorded from April 2018 to March 2019, divided into three seasons: summer (March-June), rainy (July-October) and winter (November-February). These goats were divided into three groups: kids (0-3 months), young stocks (3-12 months) and adults (above one year) based on age. The diseases observed were coded as respiratory diseases, digestive diseases, specific infectious diseases and accidents/predation/theft. Overall morbidity and mortality rates were 26.07% and 5.38%, respectively. Morbidity and mortality due to respiratory and digestive diseases were higher as compared to other disease categories. Morbidity was the highest in kids whereas mortality was more prominent among young stocks. Both morbidity and mortality occurred mostly in rainy season than winter followed by summer and were more prominent in male goats than females. Chi-square analysis revealed that morbidity and mortality had significant (p
Towards Enhancing Happiness at Work with the Lenses of Positive Organizational Behavior: the Roles of Psychological Capital, Social Capital and Organizational Trust

In this study, based on the approach of humanization of the postmodern organizations and depending on the conceptual background, it was suggested that psychological capital and social capital could be the significant antecedents of employee happiness at workplace. Further, it was proposed that organizational trust has a moderating role on the impact of psychological capital on happiness at workplace. Thereby, a cross-sectional research study has been performed in Turkey with the participation of 222 employees from a variety of sectors including sales, marketing, health, banking, finance and education. According to the findings, it was reported that the psychological capital construct (β= ,778; t=18,370, p 0,05), thus hypothesis 3 was not confirmed. Further research direction and the need for research on organizational trust’s moderating role are discussed. The conceptual and practical implications of the study are provided along with the concluding remarks and discussions.
THE RESEARCH OF ANATOMICAL STRUCTURES AND THREE ACTIVITY OF ANTIOXIDASES' CHANGE OF GRAFTED CUCUMBER SEEDLING

Take the black mole pumpkin as the stock,and Take the cucumber of "Jin han 3" as the scion.Anatomy observation of the grafts seedling and the difference in SOD,POD,CAT of scion,callus and stock,and the stocks.Through anatomy observation of the grafts seedling,the results,show that :The first stage :after grafts 1d and 2day,insulating layer forms;The second stage :after grafts 3d and 4d ,callus forms;The third stage :after grafts 5d and 6d,callus split,embrace and connect;The fourth date : after grafts 7d and 8d,cambium restores,the conducting tissue connects.After the cucumber seedling grafted 12th day,to the new vascular bundle form at the heal spot.The grafts has already survived,so the grafts clamps can be removed.And the result indicated that the graft seedlings are stronger than the offspring.SOD,POD,CAT activeness in the callus of the graft seedling is higher than the other parts of the graft seedling.POD and SOD activeness of Graft seedlings'three pots presents the tendency that rise firstly,then drop;its max value appears after grafted 6 days.CAT activeness of Graft seedlings' have the max value appears after grafted 10 days.
Postbiotics as Promising Tools for Cancer Adjuvant Therapy

As many investigations have reported, there is a complicated relation between fermented foods, lactic acid bacteria (LAB), and human health. It seems that bioactive components such as prebiotics, probiotics, and postbiotics are key mediators of the complex and direct association between these factors. LAB activity in the matrix of fermented foods and improving their growth by prebiotic compounds ultimately results in the production of bioactive molecules (postbiotics), which possess specific biological and physiological properties. The term "postbiotics" refers to a complex of biological micro- and macromolecules, if consumed in adequate amounts, provides the host with different health-promoting effects. Different reports have suggested that postbiotics possess the ability to moderate the effectiveness of cancer treatment and reduce the side-effects of conventional therapies in cancer patients due to their anti-proliferative, anti-inflammatory and anti-cancer properties. Consequently, postbiotics, for their unique characteristics, have gained great scientific attention and are considered as a novel approach for adjuvant therapy in patients with cancer.
Performance evaluation of PI controller for positive output Luo converter

The aim of this work is to design and analyze a Proportional Integral (PI) controller for Positive Output Luo Converter applications. Positive Output Luo Converter is a developed DC-DC converter. It is respected as a right choice for most industrial application where the rate of the output load voltage must be varying between the low and high values of the input value of voltage, output voltage rise and fall is smaller. This converter involve Power electronics switches (Diodes and MOSFET) since these elements are non-linear. The detailed model includes high-frequency switching that is introducing discontinuities into the model. PI controller coefficients (kp, ki) are calculated by particle swarm optimization (PSO) to provide optimal PI as hybrid PI by PSO controller with simple design procedure . Transient and steady state responses requirement of the system are considered in designing the proposed PI controller. The consequences show that the time of performing characteristics of PSO-PI controller established on integral squared error (ISE) performance index has the best time performing characteristics, line disturbance, load disturbance and set point variation.
Unmanned Aerial Vehicle Formation Flying Path Plan by Combined Algorithm of Potential and Lyapunov

: This paper discussed and introduced a new path-planning algorithm, based on improved potential field and Lyapunov guidance vector field. According to the requirements of the unmanned aerial vehicle for tracking and obstacle avoidance mission, a real-time method is proposed by combined algorithm of Lyapunov and potential. The features of this newly introduced algorithm are real-time, fast computing and obstacle avoidance capability which causes the algorithm to perform well in complex environments and applications like coordinated tracking of unmanned aerial vehicles. Improved potential flow field primarily provides obstacle avoidance feature and Lyapunov guidance vector field provides tracking feature for this newly introduced algorithm. To achieve the mission of tracking the target and avoid the obstacle at the same time, the guidance vector field by Lyapunov guidance vector field is taken as the original vector field of improved potential flow field. The results prove that the new hybrid and combined method is applicable to complex environments and complex application like coordinate tracking of moving target.
Optical Coherence Tomography as a Diagnostic Tool of Ischemic Macular Edema of Diabetic Retinopathy

Background: Diabetic Macular Ischemia (DMI) is recognized as an important cause of visual disability, it is considered as an important clinical feature of Diabetic Retinopathy (DR). Disorganization of Retinal Inner Layer (DRIL) is defined as the horizontal extent in microns for which any boundaries between the ganglion cell-inner plexiform layer complex, inner nuclear layer, and outer plexiform layer could not be identified.and considerd as featurer of capillary non perfusion. Aim of Study: To study the rule of dril assessed by Optical Coherence Tomography (OCT) in differentiation between the ischemic and non-ischemic diabetic maculopathy. Patients and Methods: 66 eyes of 66 patients were enrolled in prospective study and divided into 3 equal subgroups; control normal patients, patients with ischemic diabetic maculopathy and patients with non-ischemic diabetic maculopathy diagnosed by FFA. All patients underwent full ophthalmological examination and OCT macula was done to assess the DRIL. Results: We found that there was highly statistically significant difference (p=0.000) between non ischemic and ischemic groups as regard presence or absence of DRIL. Sensitivity of DRIL (by OCT) is 86.36%, specificity is 81.82%, positive predictive value is 82.61% and negative predictive value is 85.71%. Conclusion: There was a statistically significant difference in presence or absence of DRIL between ischemic and nonischemic diabetic retinopathy.
A survey of domain name system vulnerabilities and attacks

Aim: The Domain Name System (DNS) plays an integral role in the functionality of the Internet. Clients receive Internet service by mapping domain names into internet protocol addresses, which are routable. DNS provides a scalable and flexible name resolution service to clients easily and quickly. However, DNS was initially developed without security, and the information is not secured. Although DNS security extensions was released in 1999 to protect against vulnerabilities, it is not widely deployed, and DNS continues to suffer from a variety of attacks. The purpose of this study is to provide a comprehensive survey of DNS security. Methods: We describe an overview of DNS vulnerabilities, DNS attacks, and even mitigation systems. In detail, attacks are classified by purpose and methods for defending against these attacks are introduced and assessed. Finally, we conclude with a summary of the current state of DNS security. Results: The main findings of this study is to introduce fundamental vulnerabilities of DNS and classify representative DNS attacks into four categories to efficiently analyze them. Moreover, we describe and assess mitigation systems to defense these attacks. Conclusion: We conclude that DNS is an integral part of Internet operations but is still exposed to various attacks due to its vulnerabilities, low deployment of available mitigation techniques, and limitations of such techniques.
Factor Influencing the Resurgence of Brown Planthopper in Bangladesh

Possible causes of brown plant hopper resurgence were determined at the net-house of Entomology Division of Bangladesh Rice Research Institute (BRRI) during 2015. Causes of resurgence in the form of resurgence ratios were higher with acetamiprid, acephate, chlorpyrifos, cypermethrin, deltamethrin, fenvalerate, lambda cyhalothrin, thiamethoxam insecticides compared to imidacloprid, cartap, dinotefuran, isoprocarb /MIPC, phenthoate, pymetrozine when even applied at recommended dose. However, thiamethoxam, imidacloprid, isoprocarb / MIPC and cartap applied at sub-lethal dose produced higher resurgence ratio of BPH than others. Isoprocarb / MIPC, a commonly used recommended insecticide was found to have a higher resurgence ratio with the insecticide treatment at the egg stage (1.71) and combination of all stages (0.82). These insecticides influenced on the growth and reproductive physiology of rice brown planthopper and consequently resurgence ratio ranged increased. SAARC J. Agri. , 18(1): 117-128 (2020)
Dominant synoptic patterns associated with the decay process of PM2.5 pollution episodes around Beijing

Abstract. The variation in the concentrations of ambient PM2.5 (particles with an aerodynamic diameter less than 2.5 µm) generally forms a continuous sawtooth cycle with a recurring smooth increase followed by a sharp decrease. The episode of abrupt decay of pollution is mostly meteorological in origin and is controlled by the passage of synoptic systems. One affordable and effective measure for quickly reducing PM2.5 concentrations in northern China is to wait for a strong wind to arrive. However, it is still unclear how strong the wind needs to be and exactly what kind of synoptic system most effectively results in the rapid decay of air pollution episodes. PM2.5 variations over the 28 pollution channel cities of the Beijing region are investigated to determine the mechanisms by which synoptic patterns affect the decay processes of pollution episodes. This work shows more obvious day-to-day variations in PM2.5 concentration in winter than in summer, which implies that wintertime PM2.5 variations are more sensitive to meteorological factors. There were 365 decay processes from January 2014 to March 2020, and 97 of them were related to the effective wet deposition. In total, 26 %–43 % of PM2.5 pollutant is removed by the wet deposition in different seasons. Two dominant circulation patterns are identified in summer. All the other three seasons have three circulation types (CTs), respectively. The three CTs in spring show the same patterns as those in autumn and winter. The circulation patterns beneficial to the decay processes all exhibit a higher-than-normal surface wind speed, a negative relative humidity anomaly and net outflow of PM2.5 from the domain. In addition, CT1 in spring, autumn and winter is controlled by northeasterly wind and features the most significant horizontal net outflow of air pollutants and effective upward spread of air pollutants to the free atmosphere. CT2 is the most frequent CT in autumn and winter, with the highest wind speed from the northwest, highest boundary layer height (BLH) and lowest relative humidity among the three CTs, all of which are favorable for the reduction of PM2.5 concentrations. In CT3, strong vertical wind shear within the boundary layer enhances the mixing of surface air pollutants, which is the extra cleaning mechanism besides dry and clean air mass inflow. PM2.5 concentrations show significant decreases of more than 37 %, 41 % and 27 % after the passage of CT1, CT2 and CT3, respectively. A dry airflow with a positive BLH anomaly and the effective horizontal outflow of air pollutants are the main reasons for the abrupt decay phase in summer. PM2.5 concentrations after the decay process show a significant decreasing trend from 2014 to 2020, reflecting successful emission mitigation. Emission reductions have led to a 4.3–5.7 µgm-3yr-1 decrease in PM2.5 concentrations in the 28 pollution channel cities of the Beijing region.