Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor Necrosis Factor Receptor 2 (TNFR2)·Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-κB Activation*

Background: TNFR1 signaling has been intensively studied, but it remains unclear how TNFR2 transduces TNF-α signal under inflammatory conditions. Results: TNFR2 associates with IL-17RD, resulting in receptor aggregation and TRAF2 recruitment, leading to promotion of NF-κB signaling in renal tubular epithelial cells. Conclusion: TNFR2 cooperates with IL-17RD to activate NF-κB. Significance: The TNFR2·IL-17RD heteromer might be implicated in nephritis. TNF receptor 2 (TNFR2) exerts diverse roles in the pathogenesis of inflammatory and autoimmune diseases. Here, we report that TNFR2 but not TNFR1 forms a heteromer with interleukin-17 receptor D (IL-17RD), also named Sef, to activate NF-κB signaling. TNFR2 associates with IL-17RD, leading to mutual receptor aggregation and TRAF2 recruitment, which further activate the downstream cascade of NF-κB signaling. Depletion of IL-17RD impaired TNFR2-mediated activation of NF-κB signaling. Importantly, IL-17RD was markedly increased in renal tubular epithelial cells in nephritis rats, and a strong interaction of TNFR2 and IL-17RD was observed in the renal epithelia. The IL-17RD·TNFR2 complex in activation of NF-κB may explain the role of TNFR2 in inflammatory diseases including nephritis.
Gamification in the Workplace: The Central Role of the Aesthetic Experience

Abstract Although gamification in the workplace is burgeoning, organizations frequently have difficulty sustaining user engagement with a gamified information system (IS). The focus of this study is how a gamified IS in the workplace engages users and encourages them to continue system use. By proposing the concepts of flow experience (FE) and aesthetic experience (AE) as different ways to provide deep and meaningful user engagement, this study develops a model that explores the antecedents of FE and AE and their roles in explaining an individual’s continuance intention to use of a gamified IS. The model is tested using data collected from 178 users of a gamified IS in a global consulting company. The results demonstrate that although FE and AE are complementary forces, AE is more salient than FE for explaining continuance intention. The research proposes AE as a parsimonious yet powerful construct that extends the research on user engagement. The findings contribute to research on gamification by shifting scholarly attention from deep engagement characterized by FE to meaningful engagement characterized by AE.
ENERGY AND PROTEIN INTERACTION OF THE LACTATING SOW

Improved genetics, nutrition, housing and management systems have permitted significant increases in milk production of lactating sows. In 1972, Boomgaardt et al. (1972) studied sows that produced about 8.5 pounds of milk daily. In contrast, Johnston et al. (1993) reported daily litter growth rates of 4.86 pounds which equates to an estimated milk production of 19.5 pounds per day. In spite of these large improvements, the genetic potential for growth of nursing piglets is still not realized (Boyd et al., 1995) suggesting that improved nutritional programs that result in increased milk production will increase growth rate of nursing pigs. Heavier pigs at weaning may be of particular importance in modern production systems that implement relatively short lactations (1418 days).
Control of MHC Class I Traffic from the Endoplasmic Reticulum by Cellular Chaperones and Viral Anti‐Chaperones

MHC class I molecules assemble with peptides in the endoplasmic reticulum (ER). To ensure that only peptide‐loaded MHC molecules leave the ER, empty molecules are retained by ER‐resident chaperones, most notably the MHC‐specific tapasin. ER exit of class I MHC is also controlled by viruses, but for the opposite purpose of preventing peptide presentation to T cells. Interestingly, some viral proteins are able to retain MHC class I molecules in the ER despite being transported. By contrast, other viral proteins exit the ER only upon binding to class I MHC, thereby rerouting newly synthesized class I molecules to intracellular sites of proteolysis. Thus, immune escape can be achieved by reversing, inhibiting or redirecting the chaperone‐assisted MHC class I folding, assembly and intracellular transport.
Application of Wavelets Analysis in Image Denoising

Aiming at the problems of images denoising, wavelet algorithm is introduced simply. The technology of images denoising based on wavelet are analyzed in detail. Image denoising is achieved by Matlab. Two thresholding in the process of image denoising are compared by the results of experiments. Meanwhile, the advantages of image denoising by wavelet is proved.
Voice in Virtual Worlds: The Design, Use, and Influence of Voice Chat in Online Play

Communication is a critical aspect of any collaborative system. In online multiplayer games and virtual worlds it is especially complex. Users are present over long periods, require both synchronous and asynchronous communication, and may prefer to be pseudonymous or engage in identity-play while managing virtual and physical use contexts. Initially the only medium for player-to-player communication in virtual worlds was text, a medium well suited to identity-play and asynchronous communication, less so to fast-paced coordination and sociability among friends. During the past decade vendors have introduced facilities for gamers to communicate by voice. Yet little research has been conducted to help us understand the influence of voice on the experience of using virtual space: Where, when, and for whom voice is beneficial, and how it might be configured. To address this gap we examined a range of online gaming environments. We analyzed our observations in the light of theory from Human–Computer Interaction, Computer-Supported Cooperative Work, and Computer-Mediated Communication. We conclude that voice radically transforms the experience of online gaming, making virtual spaces more intensely social but removing some of the opportunity for identity play, multitasking, and multigaming while introducing ambiguity over what is being transmitted to whom.
Chromosomal Fragments Transmitted through Three Generations in Oncopeltus (Hemiptera)

Chromosomal fragments and translocations induced by x-rays in the sperm of adult milkweed bugs, Oncopeltus fasciatus (Dallas), were detected in the meiotic cells of F1, F2, and F3, males and caused high levels of sterility in lintreated progeny. The persistence of these fragments through numerous generations of cells confirmed the holokinetic nature of the milkweed bug chromosomes.
Sociality in Web Forum

We use exponential random graph to examine the generative processes that give rise to widespread sociality patterns in web forums. We apply the methods to Yahoo finance Wal-Mart message board from 1999 to 2008 to investigate authors’ propensities to establish relationship increase by activity. Research results shows that although having the lowest percentage in Web forums, medium activity authors are more social than high activity authors, which shows the consistent pattern with few core members contributing the majority of content. Considering sentiment, objective authors have the highest sociality, followed by negative subjective authors, which is proportional to the constitution of author sentiment group. Similar situation happened in author sociality by class, authors’ tendency to establish relationship is quite different. We conclude with a discussion of how exponential random graph may contribute to our understanding of social interaction structure and the processes that create it.
Scalability of Fully Planar NAND Flash Memory Arrays Below 45nm

We have simulated the coupling ratios in fully planar NAND arrays. We have shown that floating gate interference is no fundamental limitation for channel lengths down to 15 nm. The main limitation for scaling NAND arrays is the loss of control gate coupling due to fringing fields, leading to a strong increase in the programming voltage of the memory cells, even when using a 5 nm EOT IPD.
Early CPAP/minimal handling

Sir, In the February (1993) issue of Acta Padiatvica we showed early CPAP, with tolerance of high PCOz administered via nasal prongs to be effective-and lenient-in most very-low-birth-weight infants of more than 25 weeks’ gestation (1). Not unexpectedly, our “early CPAP/minimal handling” approach has been met with considerable scepticism by colleagues who, like Roberton ( 2 ) , believe the opposite to be the case: the “respiratory control” approach with routine intubation in the labour ward and mechanical ventilation when PCOZ rises above 6 kPa (45 mm) (3). “Where lies the truth” and “What is the way forward” are therefore relevant and constructive questions posed by Halliday (4), who calls for a prospective randomized trial. Before commenting on the latter 1 have to emphasize a few pertinent facts. First, the “early CPAP/minimal handling” approach in various modifications is in common use in Denmark and Sweden today, with results that on the whole confirm our own results (e.g. 5, 6). Second, admittedly the Scandinavian populations benefit from good socio-economic conditions, which most likely have a positive impact even on the health of our very-low-birth-weight infants, but the impact is certainly not of a magnitude that makes them “extremely healthy”, as Roberton seems to believe. In fact, the majority of our cohort (1) would have been intubated and mechanically ventilated because of rising PCOz had the babies been born in Cambridge. Third, early NCPAP works well also outside Scandinavia, e.g. in the Columbia Presbyterian Medical Center (7) , where 58% of very-low-birth-weight infants could be treated without intubation and ventilation with a survival rate of 79%. Now then, will a randomized, controlled study be necessary, and will it be feasible‘? Yes, I believe the answer to both questions is yes. But T also believe that i t will be very difficult to conduct for the following reasons: the investigating center(s) must master both techniques and also have no ethical problems with either. While the first condition is fulfilled in a number of centers in Scandinavia I am not aware of any “early CPAP/minimal handling” center that could participate because of problems with the ethical aspects. We find that till now the documented facts: survival rates, complication rates (including BPD) and-in particular-the health outcome of the survivors dictate that we develop the “early CPAP/minimal handling” technique further by giving surfactant to selected infants with RDS instead of adopting the “early intubation/respiratory control” approach.
Magnetoresistance and Hall resistivity of semimetal WTe2 ultrathin flakes

This article reports the characterization of WTe2 thin flake magnetoresistance and Hall resistivity. We found it does not exhibit magnetoresistance saturation when subject to high fields, in a manner similar to their bulk characteristics. The linearity of Hall resistivity in our devices confirms the compensation of electrons and holes. By relating experimental results to a classic two-band model, the lower magnetoresistance values in our samples is demonstrated to be caused by decreased carrier mobility. The dependence of mobility on temperature indicates the main role of optical phonon scattering at high temperatures. Our results provide more detailed information on carrier behavior and scattering mechanisms in WTe2 thin films.
Abiotic and biotic determinants of the seasonal dynamics of the tick Rhipicephalus appendiculatus in South Africa

Abstract. The creation of a generic population model for the tick Rhipicephalus appendiculatus requires a detailed, quantified understanding of the interactions of these ticks with their biotic and abiotic environment in the different parts of their range, from the tropical regions of East Africa to the temperate regions of South Africa. The much greater seasonal variation in climatic conditions, particularly temperature, further from the equator introduces variable development rates and diapause into the life cycle. Estimates of natural temperature‐dependent interstadial development periods, derived from a combination of published laboratory and field data, were applied to published data on the seasonal abundance of R.appendiculatus on three farms in the Eastern Cape Province of South Africa. This enabled an assessment of which ticks of one stage give rise to which ticks of the next stage, from which (a) the onset and duration of diapause in unfed adults, and (b) seasonal interstadial mortality indices in the form of fc‐values, could be estimated. The contribution of biotic (tick density) and abiotic (climatic) factors as predictors of mortality at each life stage was investigated by step‐wise multiple regression. Density‐independent mortality at the female‐to‐larval stage is correlated with geographically variable climatic factors, minimum temperature at two farms and minimum relative humidity at the third. The other two stages are governed by density‐dependent mortality, which, it is argued, may be caused largely by the hosts' acquired resistance to ticks. As expected on theoretical grounds, this density dependence is weaker nearer to the edge of the tick's range and for the more vulnerable immature stages.
Automatic Text Summarization in Digital Libraries

This chapter describes various text summarization techniques and evaluation techniques that have been proposed in literature and discusses the application of text summarization in digital libraries. First, it introduces the history of automatic text summarization and various types of summaries. Next, it reviews various approaches which have been used for single-document and multidocument summarization. Then, it describes the major evaluation approaches for assessing the generated summaries. Finally, it outlines the principal trends of the area of automatic text summarization. This chapter aims to help the reader to obtain a clear overview of the text summarization field and facilitate the application of text summarization in digital libraries.
Effect of high-intensity inspiratory muscle training on lung volumes, diaphragm thickness, and exercise capacity in subjects who are healthy.

BACKGROUND AND PURPOSE Previous investigations have demonstrated that a regimen of high-intensity inspiratory muscle training (IMT) resulted in changes in ventilatory function and exercise capacity in patients with chronic lung disease, although the effect of high-intensity IMT in subjects who are healthy is yet to be determined. The purpose of this study, therefore, was to examine whether high-intensity IMT resulted in changes in ventilatory function and exercise capacity in subjects who were healthy. SUBJECTS Twenty subjects were randomly assigned to 2 groups. METHODS The training group completed an 8-week program of IMT set at 80% of maximal effort. The control group did not participate in any form of training. Baseline and posttraining measures of body composition, pulmonary function, inspiratory muscle function (including maximal and sustained maximal inspiratory pressures [MIP and SMIP]), relaxed and contracted diaphragm thickness and thickening ratio (Tdi.rel, Tdi.cont, and TR), and exercise capacity were determined. RESULTS The training group demonstrated significant increases in MIP, SMIP, Tdi.cont, TR, VC, total lung capacity, and exercise capacity compared with the control group, which demonstrated no change from baseline measurements at 8 weeks. DISCUSSION AND CONCLUSION The findings of this study suggest that high-intensity IMT results in increased contracted diaphragm thickness and increased lung volumes and exercise capacity in people who are healthy.
Subjective memory complaints, depressive symptoms and instrumental activities of daily living in mild cognitive impairment

ABSTRACT Background: The diagnostic relevance of subjective memory complaints (SMCs) in mild cognitive impairment (MCI) remains to be unresolved. The aim of this study is to determine clinical correlates of SMCs in MCI. Furthermore, we examined whether there are the differences due to different aspects of complaints (i.e. prospective memory (PM) versus retrospective memory (RM) complaints). Methods: We examined the cross-sectional associations between SMCs and depressive symptoms, instrumental activities of daily living (IADL), and cognitive measures in sixty-six individuals with MCI (mean age: 65.7 ± 8.01 years). The criteria for MCI included SMCs, objective cognitive impairment, normal general cognitive function, largely intact functional activities, and absence of dementia. SMCs were assessed using the Prospective and Retrospective Memory Questionnaire (PRMQ), which contains 16 items describing everyday memory failure of both PM and RM. Results: SMC severity (i.e. PRMQ total score) was associated with stronger depressive symptoms and worse IADL performance. SMCs were not related to cognitive measures. For PM and RM subscores, both depressive symptoms and IADL were related to the PRMQ-PM and -RM scores. The main contributors to these PM and RM scores were depressive symptoms and IADL impairment, respectively. Conclusions: This study suggests that SMCs are more associated with depressive symptoms and IADL problems than with cognitive performance in individuals with MCI. Furthermore, while PM and RM complaints are related to both depressive symptoms and IADL, the differences between these main contributors suggest that RM complaints based on IADL could be more associated with the organically driven pathological features of MCI.
Optimization of active yaw control in an autonomous electric racing car

This paper shows the advantage of autonomous driving systems from testing point of view in order to enhance the performance of a racing car with respect to the use of driver assistant systems (DAS). Specifically, for the development of such systems it is necessary to perform parameter studies based on repeatable driving maneuvers. Even well trained test drivers have limited ability to achieve the required repeatability of the vehicle behavior, especially when driving at the stability limit of the vehicle. The autonomous vehicle guarantees the required position accuracy for the driving maneuvers even at high lateral acceleration with different controller settings of Active Yaw Control under real conditions. Such parameter studies are usually done using simulation tools that need very precise nonlinear tire characteristics. In this research study the Active Yaw Control was optimized using the autonomous test mode and it enhances the driving behavior in a way that a 20% higher lateral acceleration can be reached. Under-or oversteering is avoided by different wheel torques on the rear axle without compromising longitudinal dynamics.
Mechanism of negative bias temperature instability in CMOS devices: degradation, recovery and impact of nitrogen

NBTI mechanism is discussed for a wide range of stress conditions. Conditions for interface and bulk-trap generation are shown. The bias, time and temperature dependence of interface-trap buildup and recovery are discussed using the framework of the R-D model. The AC frequency dependence and impact of gate oxide nitridation are also discussed.
Classification of Protein Structure (RMSD <= 6A ˚ ) using Physicochemical Properties

The quality of the protein structure can be determined by physical and chemical properties, therefore it has been used to distinguish native or native like structure from other predicted structures. In this study, the machine learning classification models are explored with six physical and chemical properties to classify the root mean square deviation (RMSD) of the protein structure in absence of its true native state and each
Coparenting in relation to children's psychosocial and diabetes-specific adjustment.

OBJECTIVE To explore the potential utility of a general and diabetes-specific measure of coparenting by evaluating linkages between coparenting and both the psychosocial and medical adjustment of children with type 1 diabetes (TID). METHOD Mothers and fathers of children (ages 8-12 years; n=61) with TID completed questionnaires including measures of general and diabetes-specific coparenting, and children's internalizing and externalizing problems. Medical adjustment included parent-reported diabetes management behaviors, children's self-reported diabetes quality of life (QOL), and metabolic control (HbA1c) assessed during clinic appointments. RESULTS Coparenting conflict around general child rearing tasks was significantly related to children's internalizing and externalizing problems. Diabetes-specific coparenting conflict was linked to poorer diabetes management behaviors and children's reports of poorer diabetes-specific quality of life, but not HbA1c. CONCLUSIONS Significant findings offer preliminary support for the inclusion of coparenting assessments among children with TID and warrant further exploration.
Cardiac sympathetic nerve activity and heart rate during coronary occlusion in awake cats.

Responses in efferent cardiac sympathetic nerve activity (CSNA) and heart rate (HR) to a 100-s anterior descending coronary artery occlusion were measured in cats under awake, atropinized, anesthetized, or anesthetized and atropinized states. In the conscious state, at 20 and 90 s of occlusion, CSNA increased by 23% and then decreased by 7%, respectively, whereas HR decreased by 5 and 17%, respectively. With atropinization and/or anesthesia, the initial increase in CSNA was inhibited and the later decrease in CSNA was enhanced, whereas the bradycardia was diminished. HR changed in proportion to CSNA responses with high correlations, i.e., r = +0.89, +0.90, +0.96, and +0.91 for the four states, respectively. In the conscious state, the CSNA-HR relation line shifted toward bradycardia, but this shift was blocked by atropinization and anesthesia. This finding suggested that, in the conscious state, cardiac vagal nerve activity (CVNA) increased immediately and did not decrease during occlusion. At the early stage of occlusion, HR response (bradycardia or tachycardia) was determined by the relative contribution of enhanced CSNA and CVNA. At the later stage of occlusion, bradycardia was induced by a combination of decreased CSNA and enhanced CVNA. In anesthesia and/or atropinization it was induced mainly by the decreased CSNA.
Tear IgA and Serum IgG Antibodies Against Acanthamoeba in Patients With Acanthamoeba Keratitis

Purpose. Exposure to Acanthamoeba species appears to be ubiquitous, as 50% to 100% of healthy human subjects display anti-Acanthamoeba antibodies. However, the presence of specific anti-Acanthamoeba antibodies in the serum and tears of patients has not been investigated. The prevalence of serum immunoglobulin G (IgG) and tear IgA against three species of Acanthamoeba was assessed in healthy subjects and patients with Acanthamoeba keratitis. Methods. The level of specific serum IgG and tear IgA against A. castellanii, A. astronyxis, and A. culbertsoni in the sera of 23 patients and 25 healthy subjects was tested by enzyme-linked immunosorbent assays. Total serum IgM, IgG, and IgA concentrations were measured by nephelometry. Acanthamoeba keratitis was diagnosed clinically and confirmed by in vivo confocal microscopy. In some patients, corneal biopsies were also performed and trophozoites were cultured on lawns of Escherichia coli on non-nutrient agar. Results. All healthy subjects and patients with Acanthamoeba keratitis had detectable serum IgG antibodies against all Acanthamoeba antigens. However, patients with Acanthamoeba keratitis had significantly higher anti-Acanthamoeba IgG antibody titers than healthy subjects. In contrast, Acanthamoeba-specific tear IgA was significantly lower in patients with Acanthamoeba keratitis in comparison with healthy subjects. Total serum immunoglobulins did not differ significantly between healthy subjects and patients with Acanthamoeba keratitis. Conclusions. The results suggest that a low level of anti-Acanthamoeba IgA antibody in the tears appears to be associated with Acanthamoeba keratitis.