Miracle-dz/UniFAR-FTUs huggingface dataset:
Typology and Models of Cruise Travellers’ Consumption in Coastal Tourist Destinations

Purpose: The aim of this study is to identify the typology of cruise travellers taking into account the consumer behaviour in the coastal destinations related to various functions performed on the cruise tourism market, and also to present models of consumption and mathematical formulas which allow to estimate the total travellers’ spending, The research questions are as follows: 1) What are the types of consumers on the cruising market? 2) What are the types of cruise tourist destinations (CTD)? 3) What functions are performed by cruise travellers in various CTD? 4) How can we calculate the cruise travellers’ total expenditures? Design/Methodology/Approach: The research methods applied are literature review, exploration method of data, desk research and comparative analysis. Findings: The study showed a gap in consumer consumption on cruising market regarding cruise travellers’ expenditures incurred before and after a cruise voyage. This makes it difficult to estimate the total cruise travellers’ expenditures connected with an idea of “cruise voyage”. This also obviously has an impact on the difficulties in estimating revenues from cruise travels not only for travellers’ places of residence but also for the reception areas. Furthermore, there is still insufficient data on cruise travellers’ expenditures on board cruise ships which are not included in a tourist package. Analyses indicate that cruise travellers bear much more higher costs related to their cruise voyage, than they expected or were unaware of it. Practical Implications: The results of the foregoing may constitute an interesting source of information for tour-operators, cruise companies and local authorities in coastal tourist destinations Originality/Value: The review of the most important publications on consumption related to services and consumption modelling, including publications on the tourist market, has showed that there is a gap in literature when it comes to theoretical models of consumption and typology of tourists on the cruise tourism market. The knowledge of consumption models is important in assessment of economic effects generated from tourist service in coastal regions.
Production Performance, Hematology and Serum Biochemistry of Commercial Broilers Supplemented with Nano Selenium and other Anti-Stressors during Summer

The aim of this study is to determine the effect of dietary supplementation of nano selenium on production performance in commercial broilers during summer stress. Dietary nano selenium was compared with other anti-stressors such as inorganic selenium, Vitamin E, Vitamin C, Betaine and 1% Glutamine. A total of 420 commercial broilers were divided into seven treatments with three replicates of 20 birds each and were supplemented with basal diet (control), inorganic Se (0.30 mg/kg), nano Se (0.15 mg/kg), Vit E (250 mg/kg), Betaine (2g/kg), Glutamine (1%) and Vit C (250 mg/kg). The highest body weight (1945.17 ± 25.28) and the lowest feed consumption (2973.16 ± 41.25) with better FCR (1.56 ± 0.02) was observed in birds supplemented with nano Se than other anti-stressors and control group. It was concluded that supplementation of nano Se in broiler diet improved the productivity of commercial broilers during summer stress.
Avaliação da capacidade antitumoral de nanopartículas lipídicas sólidas contendo docetaxel em células de carcinoma de ovário sensíveis e resistentes in vitro

xviii 1. INTRODUÇÃO . 1 1.1. Câncer . 1 1.2. Câncer de ovário . 4 1.2. 1. Câncer Epitelial de Ovário (CEO) . 8 1.2. 2. Resistência à multifármacos em câncer de ovário . 12 1.3. Docetaxel. 14 1.4. Sistemas de Entrega de Fármacos – Nanopartículas . 16 1.4.1 Nanopartículas lipídicas sólidas . 18 2. JUSTIFICATIVA . 21 3. OBJETIVOS . 23 3.1. Objetivo geral . 23 3.2. Objetivos específicos . 23 4. MATERIAIS E MÉTODOS . 23 4.1. Reagentes e equipamentos . 23 4.2. Nanopartículas lipídicas sólidas . 25 4.3. Cultura celular . 25 4.4. Delineamento experimental . 26 4.5. Obtenção de linhagem de carcinoma de ovário resistente A2780-MDR . 27 4.5. 1 Plasmídeos pHaMDR, GaG-Pol e VSV-G . 27
Boredom and sleep dysregulation during COVID-19 lockdown period

The onset of novel infectious disease known as Corona-virus disease (COVID-19) and it’s outbreak that has contagiously spread at a global level came to light on December 31, 2019 when the number of cases related to respiratory infection of an unknown cause in Wuhan City started increasing and China informed the World Health Organization (WHO) about it that subsequently started spreading rapidly to the rest of the world. The WHO declared the outbreak a pandemic and Public Health Emergency of International Concern on 30 January 2020. The government of respective countries ordered nationwide lockdown as a preventive measure against COVID-19, restricting and limiting the movement of entire population by adopting social distancing, mass quarantine, stay at home ordinances and that have proven effective in breaking the chain of virus from spreading and infecting others. However, a prolonged home-stay has been observed to have an undesirable consequences concerned with mental, physical and emotional health like Boredom and Sleep dysregulation along with their impact on well-being that will be addressed in this article as the impact of COVID 19 is not only limited to human infection and death, other associated issues, as mentioned, need to be taken into account
Exploring the Domestic Abuse Narratives of Trans and Nonbinary People and the Role of Cisgenderism in Identity Abuse, Misgendering, and Pathologizing

Drawing on data from two empirical studies, this article employs cisgenderism as a conceptual tool to explore trans people’s experiences of domestic violence and abuse (DVA). Distinct modes of cisgenderism are analyzed. These are identity abuse, microaggressions, misgendering, and pathologizing practices. Qualitative data were collected via semistructured interviews (n = 24). Two inclusion criteria were used for this secondary analysis requiring participants to self-identify as trans or nonbinary and have experience of DVA. The findings illuminate the extent of cisgenderism as underpinning experiences of DVA. The article ends with a call for further theoretical and empirical research in this regard.
Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2

Background Sex differences in the incidence and progression of many liver diseases, including liver fibrosis and hepatocellular carcinoma, are associated with sex-biased expression of hundreds of genes in the liver. This sexual dimorphism is largely determined by the sex-specific pattern of pituitary growth hormone secretion, which controls a transcriptional regulatory network operative in the context of sex-biased chromatin states. Histone H3K27-trimethylation yields a major sex-biased repressive chromatin mark that is specifically deposited by polycomb repressive complex-2, via its homologous catalytic subunits Ezh1 and Ezh2, at many strongly female-biased genes in male mouse liver, but not at male-biased genes in female liver. Results We used Ezh1-knockout mice with a hepatocyte-specific knockout of Ezh2 to elucidate the sex bias of liver H3K27-trimethylation and its functional role in regulating sex-differences in the liver. Combined hepatic Ezh1/Ezh2 deficiency led to a significant loss of sex-biased gene expression, particularly in male liver, where many female-biased genes increased in expression while male-biased genes showed decreased expression. The associated loss of H3K27me3 marks, and increases in the active enhancer marks H3K27ac and H3K4me1, were also more pronounced in male liver. Many genes linked to liver fibrosis and hepatocellular carcinoma were induced in Ezh1/Ezh2-deficient livers, which may contribute to the increased sensitivity of these mice to hepatotoxin-induced liver pathology. Conclusions Ezh1/Ezh2-catalyzed H3K27-trimethyation is thus essential for the sex-dependent epigenetic regulation of liver chromatin states controlling phenotypic sex differences in liver metabolism and liver fibrosis, and may be a critical determinant of the sex-bias in liver disease susceptibility.
Risks in signal processing pipelines influencing the estimation of phase dependency for EEG-TMS

Phase-dependency of cortico-spinal excitability can be researched using TMS-EEG. Due to the large artifact, non-causal filters can smear the TMS artifact and distort the phase. However, causal filters can become biased by too high filter orders or uneven pass-bands. We explored the influence of different signal processing pipelines on the estimation of the optimal phase. This exploration involved performing two simulation studies. In the first, we simulated two different phase-dependencies (uni-versus bimodal) and sought to recover them with two distinct approaches that have previously been described. In the second, we specifically explored how filter parameters (e.g., order, pass-band) biased the phase estimation. On the basis of these findings, we propose using up-to-date toolboxes, re-running scripts after software updates and performing simulation studies in parallel to safeguard the analysis pipeline of empirical studies.
Using a large-scale biodiversity monitoring dataset to test the effectiveness of protected areas in conserving North-American breeding birds

Protected areas currently cover about 15% of the global land area and constitute one of the main tools in biodiversity conservation. Quantifying their effectiveness at protecting species from decline and local extinction involves comparing protected with counterfactual unprotected sites representing “what would have happened to protected sites if they had not been protected”. Most studies are based on pairwise comparisons, using as counterfactuals neighbour sites to protected areas, but this choice is often subjective and may be prone to biases. An alternative is to use large-scale biodiversity monitoring datasets, which whereby the effect of protected areas is analysed statistically by controlling for landscape differences between protected and unprotected sites, allowing a more targeted and clearly defined measure of protected areas effect. Here we use the North American Breeding Bird Survey dataset as a case study to investigate protected areas effectiveness in conserving bird assemblages. We analysed the effect of protected areas on species’ richness, assemblage-level abundance and abundance of individual species by modelling how these metrics relate to the proportion of each site that is protected, while controlling for site habitat, altitude, productivity and spatial autocorrelation. At the assemblage level, we found no relationship between protection and species richness or overall abundance. At the species level, we found that species that avoid human activities tend to be favoured by protected areas are the one avoiding human activities. Moreover, we found that forest protected areas presented higher abundances of forest species, making the assemblage more typical of this habitat. We did not find that declining species were particularly favoured by protected areas. Our results highlight the complexity of answering the question of protected areas effectiveness, and the necessity to define clearly metrics measured and the controls used.
Local support for conservation is associated with perceptions of good governance, social impacts, and ecological effectiveness

Local support is important for the longevity of conservation initiatives. The literature suggests that perceptions of ecological effectiveness, social impacts, and good governance will influence levels of local support for conservation. This paper examines these relationships using data from a survey of small‐scale fishermen in 11 marine protected areas from six countries in the Mediterranean Sea. The survey queried small‐scale fishermen regarding perceptions and support for conservation. We constructed composite scores for three categories of perceptions—ecological effectiveness, social impacts, and good governance—and tested the relationship with levels of support using ordinal regression models. While all three factors were positively correlated with support for conservation, perceptions of good governance and social impacts were stronger predictors of increasing support. These findings suggest that employing good governance processes and managing social impacts may be more important than ecological effectiveness for maintaining local support for conservation.
Analisa Tingkat Penerimaan Pengguna Terhadap Aplikasi SIMPUS dengan Metode Technology Acceptance Model (TAM)

Penelitian ini bertujuan melakukan Analisa Tingkat Penerimaan PenggunaTerhadap pengguna Apikasi Sistem Informasi Manajemen Puskesmas SIMPUS dengan metode TAM. Variabel yang digunakan yaitu persepsi tentang kemudahan (Perseive ease of use), Persepsi terhadap kemanfaatan (Perceived Usefulness), Sikappenggunaan (Attitude Toward Using), Perilaku untuk tetap menggunakan (Behavioral Intention To Use), Kondisi nyata pengguna sistem (Actual System Usage). Bahan dan alat penelitian adalah Aplikasi SIMPUS.Teknik pengumpulan data dengan observasi dan penyebaran kuisioner tertutupsejumlah 110 kuisioner kepada 110 pengguna aplikasi SIMPUS sebagai sampel.Hasil penelitian menunjukan pada data keenam variable berdistribusi normal (nilai Sig > 0.05) yaitu X1 (p= 0,172), X2 (p=0,171), X3 (p=0,143), X4 (p=0,117), X5 (p=0,062), Y (p=0,592). Hasil Uji Linearitas dengan menggunakan uji Durbin Watson menunjukkan bahwa tidak auto korelasi atau asumsi terpenuhi bahwa fungsi linier yaitu nilai statistic Durbin Watson (1,722) terletak diantara nilai table Durbin Watson (1,703) dan 4 – DU (2,291). Hasil Uji multikolinieritas menunjukkan bahwa tidak ada satu pun variable bebas yang memiliki nilai VIF(variance inflation factor) lebih dari 10 atau nilai toleransi kurang dari 0,10. Dan nilaiF hitung =91,469>F tabel =2,65 atau nilai p<0,05.Variabel X 1 , X 2 , X 3 ,X 4 , X 5 berpengaruh secara simultan atau bersama – sama dan signifikan terhadap penerimaan SIMPUS.Kesimpulan aspek persepsi kemudahan, persepsi kegunaan,sikap menggunakan, memberikan pengaruh nyata terhadap penerimaan SIMPUS. Sedangkan niat perilaku menggunakan, penggunaan SIMPUS sesungguhnya tidak berpengaruh terhadap penerimaan SIMPUS.
Heading computation in the human retrosplenial complex during full-body rotation

The retrosplenial complex (RSC) plays a crucial role in spatial orientation by computing heading direction and translating between distinct spatial reference frames. While invasive studies allow investigating heading computation in moving animals, established non-invasive analyses of human brain dynamics are restricted to stationary setups. To investigate the role of the RSC in heading computation of actively moving humans, we used a Mobile Brain/Body Imaging approach synchronizing electroencephalography with motion capture and virtual reality. Data from physically rotating participants were contrasted with rotations based only on visual flow. Varying rotation velocities were accompanied by pronounced beta synchronization during physical rotation. In addition, heading computation based only on visual flow replicated alpha desynchronization in the RSC, which was absent during physical rotation. These results suggest an involvement of the human RSC in heading computation based on vestibular input and implicate revisiting traditional findings of alpha desynchronization during spatial orientation in movement-restricted participants. Heading computation is fundamental for spatial orientation in the human and other species. The registration of moment-to-moment changes in orientation with respect to an allocentric reference direction provides information about an animal’s current heading relative to the environment. This is accomplished by the integration of vestibular, proprioceptive, and visual signals providing information about linear and angular velocity signals of the head, the relative position of the head with respect to the trunk, and information about stable aspects of the environment, respectively.1 Single cell recordings in freely behaving animals identified several brain structures involved in heading computation, including the retrosplenial cortex (RSC). 2, 3 The RSC receives input from the visual system and from head direction cells in the thalamic nuclei.4 It also hosts subpopulations of heading-sensitive cells that are sentient to local features of the environment, while other cells exhibit mixed activity patterns related to both local and global heading computation.5 These findings suggest that neural activity in the RSC subserves the integration of information about the local and global environment, integrating egocentrically coded landmark cues based on sensory fusion (vision and proprioception)6 with allocentric heading information originating from the Papez circuit.7 This allows the compensation of the rotational offset between egocentric and allocentric spatial representations, routed from the parietal and medial temporal cortices, providing the necessary information for translating between both egocentric and allocentric spatial representational frames in the RSC.8
A Review of Head Injury and Impact Biomechanics in Recreational Skiing and Snowboarding

Background . Skiing and snowboarding are popular competitive and recreational sports with associated head injury risks from impact hazards. Understanding head injury hazards and risks in snow sports can inform injury prevention measures, such as helmets, education and environment design of runs and terrain park features, to manage injury risk. Aim . To identify and discuss (a) the proportion and incidence of head injuries and effectiveness of helmets, (b) circumstances, situational events and characteristics of head injuries and (c) head impact biomechanics in recreational skiing and snowboarding. Methods . A narrative literature review was performed. Results . Head injuries comprise up to 38% and 29% of all injuries in skiing and snowboarding, respectively. Skull fractures were found to comprise nearly half of all moderate to severe head injuries in alpine sports across all studies. The most common intracranial injury in skiing and snowboarding was cerebral contusion and subdural haematoma, respectively. Fatal head injuries in skiing are rare with an incidence of approximately one death per one million skier-visits and less than 1% of all skiing head injuries resulted in death. The majority of head injuries were sustained by novice and intermediate level skiers and snowboarders during falls on mild or moderate gradient slopes. Head injury cases occurred in terrain parks were more common in snowboarders than skiers. Fall-related head injuries to skiers are typically in the forward direction with an impact to the front of the head, whereas snowboarders fall rearward and impact the occipital region. Helmet use has increased in recent years, but recent studies have observed an unexpected reduction of the protective effect of helmets in skiing and snowboarding. Alpine sports helmet standards require linear drops onto rigid anvils, but the correlation with snow surfaces is unknown and no helmet standard requires an oblique impact test. Significant protective effects of helmets have been found for collisions and falls onto hard snow. Conclusions . Alpine sport helmet performance standards should more closely reflect the boundary conditions of impacts to skiers and snowboarders associated with head injury. Administrative and engineering controls may also reduce the risk of head injury in skiing and snowboarding.
Mechanistic models of signaling pathways deconvolute the glioblastoma single-cell functional landscape

Abstract Single-cell RNA sequencing is revealing an unexpectedly large degree of heterogeneity in gene expression levels across cell populations. However, little is known on the functional consequences of this heterogeneity and the contribution of individual cell fate decisions to the collective behavior of the tissues these cells are part of. Here, we use mechanistic modeling of signaling circuits, which reveals a complex functional landscape at single-cell level. Different clusters of neoplastic glioblastoma cells have been defined according to their differences in signaling circuit activity profiles triggering specific cancer hallmarks, which suggest different functional strategies with distinct degrees of aggressiveness. Moreover, mechanistic modeling of effects of targeted drug inhibitions at single-cell level revealed, how in some cells, the substitution of VEGFA, the target of bevacizumab, by other expressed proteins, like PDGFD, KITLG and FGF2, keeps the VEGF pathway active, insensitive to the VEGFA inhibition by the drug. Here, we describe for the first time mechanisms that individual cells use to avoid the effect of a targeted therapy, providing an explanation for the innate resistance to the treatment displayed by some cells. Our results suggest that mechanistic modeling could become an important asset for the definition of personalized therapeutic interventions.
Optimisation de la micro-oxygénation grâce au lysozyme

Introduction Le lysozyme va être utilisé pour la 5 campagne de vinifications, et même si plus de 70% de son utilisation concerne l’application de traitement semi-préventif ou curatif de la piqûre lactique, de nombreuses autres applications se sont développées. La plupart de ces applications utilisent la propriété bactéricide du lysozyme pour décaler la fermentation malolactique, et obtenir des vins avec une couleur plus stable mais aussi un équilibre en bouche plus qualitatif. Nous présentons dans cet article un cas pratique d’utilisation du lysozyme pour amplifier l’efficacité de la micro-oxygénation, celui de la cave des Clairmonts, près de Tain l’Hermitage (26). (voir photos en fin d’article) Après plusieurs années de mise au point, l’utilisation de la micro-oxygénation en combinaison avec le lysozyme a permis d’obtenir des vins exprimant toutes les qualités de la Syrah en Côtes du Rhône Nord (AOC Crozes Hermitage), avec une amélioration du volume en bouche. La valorisation économique de la technique a permis dans ce cas précis de compenser largement l’investissement (en temps, matériels et consommables comme l’oxygène et le lysozyme).
The Dilemma of Toxic Masculinity in Eastern and Western Societies; With Reference to the Novel “Men in Prison”

This paper will focus on the notion of toxic masculinity that has a lot to do with deforming the male identity figure. I am here really concerned with probing within the need of conforming with the traditional masculinity ideology in the East and the West, and how it hinders males from discovering what it means to be a male. Actually, the scope of research in this paper exceeds one culture to include both the Western and the Eastern cultures, which have proved with evidence to share many attributes. I am also revealing how this masculinity has been misinterpreted over the years to encompass weird attitudes and behaviors as suppressing emotions or masking distress or showing violence as an indicator of power. How the idea of the necessity of being “tough all the time” may affect their mental and psychological wellbeing and what is less than that could stigmatize them for being “feminine” or “weak”. In this paper, I will also try to reveal how great sector of women unintentionally feeds this ego of toxic masculinity to their sons since childhood days. By connecting all these factors to the development of the characters in Victor Surge’s novel “Men in Prison”, we are simply highlighting the psychological dimension and consequences of suppressed men. It is regarded as an unfiltered view of humanity in the early 20th century. The depraving brutality that Serge experienced behind bars is mirroring a society subduing men in various levels. I hopefully seek to break down factors that trap men in a certain framework out of which there is no escape.