Miracle-dz/UniFAR-FTUs huggingface dataset:
Diffusion of innovations: Smartphones and wireless anatomy learning resources

The author has previously reported on principles of diffusion of innovations, the processes by which new technologies become popularly adopted, specifically in relation to anatomy and education. In presentations on adopting handheld computers [personal digital assistants (PDAs)] and personal media players for health sciences education, particular attention has been directed to the anticipated integration of PDA functions into popular cellular telephones. However, limited distribution of early “smartphones” (e.g., Palm Treo and Blackberry) has provided few potential users for anatomical learning resources. In contrast, iPod media players have been self‐adopted by millions of students, and “podcasting” has become a popular medium for distributing educational media content. The recently introduced Apple iPhone has combined smartphone and higher resolution media player capabilities. The author successfully tested the iPhone and the “work alike” iPod touch wireless media player with text‐based “flashcard” resources, existing PDF educational documents, 3D clinical imaging data, lecture “podcasts,” and clinical procedure video. These touch‐interfaced, mobile computing devices represent just the first of a new generation providing practical, scalable wireless Web access with enhanced multimedia capabilities. With widespread student self‐adoption of such new personal technology, educators can look forward to increasing portability of well‐designed, multiplatform “learn anywhere” resources. Anat Sci Ed 1:233–239, 2008. © 2008 American Association of Anatomists.
Blood Pressure and Cerebrospinal Fluid Norepinephrine in Combat-Related Posttraumatic Stress Disorder

Objective: Central nervous system norepinephrine (NE) is normally involved in blood pressure regulation, but it is pathophysiologically elevated in posttraumatic stress disorder (PTSD). Methods: We monitored blood pressure while performing serial cerebrospinal fluid (CSF) sampling for 6 hours to determine CSF NE concentrations in men with combat-related PTSD (n = 11) and in healthy men (n = 8). Results: CSF NE concentrations strongly and positively correlated with mean diastolic blood pressure in the healthy men (R = 0.93, p < .002) but not in the patients (R = 0.10, p = .77). Within individuals, mean arterial pressure, systolic blood pressure, diastolic blood pressure and pulse pressure were poorly correlated over time in patients with PTSD but highly correlated over time in the healthy men, indicating that measurement of these hemodynamic parameters are poorly prognostic of subsequent measurements of the same parameter in patients with PTSD. Conclusion: These data demonstrate the loss of the normal direct relationship between CSF NE and blood pressure in combat veterans with PTSD. Whether this dysynchrony mechanistically relates to the hemodynamic abnormalities in PTSD or, like some of the psychobehavioral symptoms, can be corrected with anti-noradrenergic pharmacotherapy remains to be determined. NE = norepinephrine; CNS = central nervous system; PTSD = posttraumatic stress disorder; CSF = cerebrospinal fluid; MAP = mean arterial pressure; BMI = body mass index; AR = autoregressive order 1 model.
Multiclass Classification of Weld Defects in Radiographic Images Based on Support Vector Machines

In this paper, we present through the experimental study the use of support vector machines (SVMs) in the automatic classification of weld defects in radiographic images. SVM is a machine learning tool used for classification and regression and it is well known for binary classification, but there are many approaches for multiclass classification, the most popular are one versus all and one versus one. The performance of the proposed classification system is evaluated using hundreds of radiographic images representing four types of defects. The experimental results show that the SVM classifier is an efficient automatic weld defect classification algorithm and can achieve high accuracy percent and is faster than multilayer perceptron artificial neural network (MLP-ANN).
Expression of Foxp4 in the developing and adult rat forebrain

Many members of the Fox family are transcription factors that regulate the morphogenesis of various organs. In the present study, we examined the expression pattern of Foxp4, a member of the Foxp subfamily, and compared its pattern with the patterns of Foxp2 and Foxp1 in the developing rat brain. In general, these three Foxp genes shared partially overlapping and yet differentially regulated expression patterns in the striatum, the cerebral cortex, and the thalamus during development. In the developing dorsal telencephalon, a mediolateral gradient of Foxp4 was present in the cortical primordium, with high levels in the ventricular zone of the medial cortex. By contrast, no gradient of Foxp2 and Foxp1 was detected in the dorsal telencephalon. At later stages, Foxp4 was expressed throughout all cortical layers as opposed to the layer‐specific expression of Foxp2 and Foxp1. In the developing striatum, the pattern of Foxp4 expression was distinct from the patterns of Foxp2 and Foxp1. The spatial expression pattern of Foxp4 was similar to that of Foxp2 during the early embryonic stage. However, from the late embryonic stage to postnatal day 4, Foxp4 was expressed in a mediolateral gradient and decreased in the striosomal compartment, in contrast to the striosomal expression of Foxp2 and homogeneous expression of Foxp1. Foxp4 was developmentally down‐regulated such that Foxp4 was undetectable in the forebrain after postnatal day 14, whereas Foxp2 and Foxp1 were persistently expressed in adulthood. Given that Foxp4, Foxp2, and Foxp1 are capable of heterodimerization for transcriptional regulation, the partially overlapping expression patterns of Foxp4, Foxp2, and Foxp1 in different domains of the developing forebrain suggest that each member and/or different combinatory actions of the Foxp subfamily may play a pivotal role in regulating forebrain development. © 2008 Wiley‐Liss, Inc.
Evaluation of Biocompatibility and Administration Site Reactogenicity of Polyanhydride‐Particle‐Based Platform for Vaccine Delivery

Efficacy, purity, safety, and potency are important attributes of vaccines. Polyanhydride particles represent a novel class of vaccine adjuvants and delivery platforms that have demonstrated the ability to enhance the stability of protein antigens as well as elicit protective immunity against bacterial pathogens. This work aims to elucidate the biocompatibility, inflammatory reactions, and particle effects on mice injected with a 5 mg dose of polyanhydride nanoparticles via common parenteral routes (subcutaneous and intramuscular). Independent of polymer chemistry, nanoparticles more effectively disseminated away from the injection site as compared to microparticles, which exhibited a depot effect. Using fluorescent probes, the in vivo distribution of three formulations of nanoparticles, following subcutaneous administration, indicated migration away from the injection site. Less inflammation was observed at the injection sites of mice‐administered nanoparticles as compared to Alum and incomplete Freund's adjuvant. Furthermore, histological evaluation revealed minimal adverse injection site reactions and minimal toxicological effects associated with the administration of nanoparticles at 30 days post‐administration. Collectively, these results demonstrate that polyanhydride nanoparticles do not induce inflammation as a cumulative effect of particle persistence or degradation and are, therefore, a viable candidate for a vaccine delivery platform.
MRS Feature Extraction: Time-Frequency and Wavelet Analysis

Magnetic Resonance Spectroscopy (MRS) signals are being used for diagnosis of various brain diseases. Feature extraction of the MRS data is the most important step in analyzing the data. In this study a fully automated system is developed to analyze the MRS signals. The wavelet analysis is utilized in extracting signal features and the time-frequency representations. Consulting specialists in the field, the sensitivity of 87.11% plusmn 18 and the positive predictivity of 88.97% plusmn 15 in extracting features have been achieved.
The Smart Grid and Future Mobile Networks: Integrating Renewable Energy Sources and Delay Tolerant Users

Recently, energy behaviour is being considered as an important key performance indicator when studying mobile networks. Reducing their operational cost is becoming more essential due to the huge increase of traffic accompanied by the increase in the electric bills. In this paper, we are going a step forward to study the possibility of a new type of energy behaviour of renewable energy-powered base stations in the Smart Grid environment. We use renewable energy and energy storage and we employ the concept of delay tolerant users to provide ancillary services to the Smart Grid. Based on real data from the French power grid, results show that the achieved profit from providing ancillary services exceeds the electric bill and leads to a negative energy operational cost.
El tratamiento del léxico en dos currículos dela Enseñanza Secundaria Obligatoria (ESO):una mirada desde el español como L2

El lexico es un elemento de primer orden en la ensenanza de las materias linguisticas y especialmente en las no linguisticas �aquellas que transmiten un determinado campo del saber� ya que, en estas ultimas, se convierte en factor clave para la expresion y comprension de los conceptos. Los alumnos inmigrantes que aprenden espanol como lengua segunda en nuestras aulas se enfrentan, por una parte, al curriculo de espanol como L2 y, por otra, a los curriculos de las diferentes asignaturas. Hemos analizado dos de ellos, de un tipo y otro de ensenanza pertenecientes a la misma etapa escolar, para comprobar si el interes que vienen mostrando en los ultimos anos las obras de investigacion sobre el lexico se refleja tambien en estos documentos que sirven de guia a las practicas docentes. Observamos ademas en que medida en estos curriculos se recogen las aportaciones de la linguistica teorica con respecto al concepto de competencia lexica.
Estimating Spectral Efficiency Curves from Connection Traces in a Live LTE Network

In cellular networks, spectral efficiency is a key parameter when designing network infrastructure. Despite the existence of theoretical model for this parameter, experience shows that real spectral efficiency is influenced by multiple factors that greatly vary in space and time and are difficult to characterize. In this paper, an automatic method for deriving the real spectral efficiency curves of a Long Term Evolution (LTE) system on a per-cell basis is proposed. The method is based on a trace processing tool that makes the most of the detailed network performance measurements collected by base stations. The method is conceived as a centralized scheme that can be integrated in commercial network planning tools. Method assessment is carried out with a large dataset of connection traces taken from a live LTE system. Results show that spectral efficiency curves largely differ from cell to cell.
Value Co-Creation for Cyber-Physical Systems in Mining and Construction Industry

This paper focuses on value co-creation in the context of cyber-physical systems (CPSs). We investigate how value is co-created in the mining and construction industry, where the intelligent equipment are examples of CPSs. We take an interpretive research approach and study a global corporation, which manufactures tools and equipment for the mining and construction industry. The data collection was done using the laddering technique (n=20) and for the analysis a thematic clustering approach was adopted. Our findings show how value is co-created in the use of intelligent equipment. More specifically, the findings indicate that the use and service experience related to intelligent equipment is important value driver in this context. Also the sharing and receiving information related to intelligent equipment use and operating environment are important. As a conclusion, the utilitarian values and goal-oriented perspective toward values were considered to be more relevant than the hedonic values.
Dizziness in Aging: A Retrospective Study of 1194 Cases

In the Royal Victoria Hospital dizziness clinic, 1194 of 9767 (12.22%) patients were 70 years of age or older on the day of the first visit. There were 750 women and 444 men, with no difference in age distribution (p > 0.9). In 367 (27.04%) cases (percentages given as “cases” refer to the number of diagnoses [N = 1357], not the number of patients [N = 1194]), the symptoms were nonspecific, and the diagnosis was uncertain. In 530 (39.13%) patients, paroxysmal positional vertigo was either confirmed or strongly suspected. In the 241 of 254 (94.88%) confirmed cases, the observed paroxysmal nystagmus was compatible with excitation of the posterior semicircular canal. In 119 (8.77%) patients, the dizziness could not be attributed to neurologic or vestibular disease. Meniere's disease, vestibular neuronitis, vascular episodes, and tumors were next in prevalence. The following conclusions were reached: (1) although no difference was found in age distribution between women and men, dizziness was more prevalent among women, which may be because of the higher survival rate of women; (2) the prevalence of paroxysmal positional vertigo was high, with apparent Involvement of the posterior semicircular canal in most cases (It is strongly suspected that paroxysmal positional vertigo is frequently misdiagnosed as vascular disease in advanced age); and (3) multisensory deficits, drugs, or systemic diseases, common in the elderly, may cause dizziness. Syndromes affecting the vestibular function, however, may be more prevalent in advanced age than is generally estimated.
Long-Term Effect of Gamma Irradiation on the Functional Properties and Cytocompatibility of Multiblock Co-Polymer Films

Abstract The purpose of this work was to investigate the long-term effect of gamma-irradiation treatment on the functional properties of PEG-PDLLA and PEG-PLGA films and to evaluate the cytocompatibility of sterilized samples. Chemical and thermal properties, and cytocompatibility of sterilized films were detected for samples at time zero and after storage at 5 ± 3°C for 60 days. An in vitro degradation study was carried out on polymer samples to examine the effect of sterilization on the degradation performances of co-polymer films. Incubated samples were characterized in terms of film surface structure (SEM), chemical (GPC) and thermal (DSC) properties. The study performed on films upon gamma sterilization showed no significant changes of the PEG-PDLLA and PEG-PLGA film structure, while GPC analysis highlighted that the effect of gamma irradiation was dependent on the Mw and composition of polymers. DSC traces suggested more pronounced gamma-ray effects on the PEG-PLGA multiblock co-polymer. During the stability study important changes in terms of structure surface, thermal properties and cytocompatibility were observed and investigated. Data collected during the in vitro degradation study emphasized the need to know and investigate the degradation performances and behaviour of polymer or polymer systems (as DDS, scaffolds and bandage) treated with gamma rays.
Heterosynaptic facilitation and post‐tetanic potentiation in Aplysia nervous system *

1. Heterosynaptic facilitation was defined as an increase of amplitude of a test excitatory post‐synaptic potential (EPSP) after the activation of a pathway (heterosynaptic pathway) different from that which produced the test EPSP. This phenomenon has been studied in Aplysia central nervous system under conditions which excluded the participation of post‐tetanic potentiation.
Neurological Variant of Lemierre's Syndrome with Purulent Meningitis: A Case Report and Literature Review

We report an unusual variant of Lemierre's Syndrome (LS) in a 10-year-old-girl admitted to the intensive care unit for septic shock with meningitis. The primary infection was otitis media. A gram negative bacillus was identified in the direct exam of the purulent ear discharge and the cerebrospinal fluid but cultures were negative. Computerized tomography of the neck revealed a thrombus in the internal jugular vein. Septic shock improved rapidly under supportive treatment. The patient recovered without sequellae after a prolonged duration of parenteral antibiotherapy and hospital stay. Neurologic variants of LS with meningitis, previously reported in the literature, are reviewed.
Development and Validation of a Gamma Interferon ELISPOT Assay for Quantitation of Cellular Immune Responses to Varicella-Zoster Virus

ABSTRACT Cell-mediated immunity appears to be critical for the prevention and control of varicella-zoster virus (VZV) infection and complications arising from zoster. Current assays of VZV-specific cell-mediated immunity are cumbersome or lack sensitivity. We have developed a gamma interferon ELISPOT assay that provides a direct measure of the number of T cells secreting a cytokine following stimulation with antigen. This assay is extremely sensitive and specific, with the ability to detect gamma interferon spot-forming cells (SFC) in the range of 10 to 1,000 SFC per million peripheral blood mononuclear cells (PBMCs). This assay has been validated by demonstrating the following: (i) the response detected is mediated almost entirely by CD4+ T cells, (ii) ELISPOT responses from fresh-frozen PBMCs are equivalent to those from freshly isolated cells, (iii) frozen PBMCs can be shipped on dry ice for up to 48 h without loss of activity, (iv) frozen PBMC samples can be stored in liquid nitrogen over long periods (>22 months) without any significant change in response, and (v) the numbers of ELISPOTs counted using a computer-based imaging system are equivalent to those counted by humans but have lower variability. The ability to use frozen cells is facilitated by the use of a recombinant nuclease (Benzonase) that can prevent cell clumping when samples are thawed. Frozen PBMC samples can be cycled through multiple changes in storage between liquid nitrogen and dry ice without any change in response being detected. This facilitates collection of samples at one site and testing performed at a remote location. This VZV ELISPOT assay provides a new versatile tool for monitoring cellular immune responses either during a herpes zoster disease outbreak or following vaccination.
Adenine nucleotide degradation in slow-twitch red muscle.

The catabolism of adenine nucleotides (AdN) in rat soleus muscle (predominantly slow twitch) is very different from that in fast-twitch muscle. AMP deaminase is highly inhibited during brief (3 min) intense (120 tetani/min) in situ stimulation, resulting in little inosine 5'-monophosphate (IMP) accumulation (0.21 mumol/g). Even with ligation of the femoral artery during the same brief intense contraction conditions there is surprisingly little increase in IMP (0.37 mumol/g), although AdN depletion is evident (-1.30 mumol/g). We have tested the hypothesis that accumulation of purine nucleosides and bases accounts for the AdN depletion by measuring purine degradation products using high-performance liquid chromatography. There was no stoichiometric accumulation of purine degradation products to account for the observed AdN depletion even though metabolite recovery was essentially quantitative. We hypothesis that under these conditions AdN are converted to a form different from purine nucleoside and base degradation products. In contrast to the inhibition of AMP deamination seen during brief ischemia, slow-twitch muscle depletes a substantial fraction (28%) of muscle AdN (1.75 mumol/g) that can be accounted for stoichiometrically as purine degradation products during an extended 10-min ischemic period of mild (12 tetani/min) contraction conditions. IMP accumulation (1 mumol/g) is most prominent with inosine, accounting for 23% (0.4 mumol/g) of the depleted AdN, showing that slow-twitch red muscle is capable of both AMP deamination and the subsequent production of purine nucleosides during an extended period of ischemic contractions. The present results indicate that AdN metabolism in the soleus muscle is complex, yielding expected degradation products or a loss of total purines, depending on contraction conditions. (ABSTRACT TRUNCATED AT 250 WORDS)
Mechanisms of Age‐Related Differences in the Cardiotoxic Action of Digitalis

Age-associated ouabain sensitivity was investigated in isolated perfused guinea pig heart and the findings were correlated with its receptor function. Ouabain (0.1 μmol L−1) produced average positive inotropic responses of 22% in 15-day-old, 25% in 4–6 month-old, and 34% in 18–24-month-old guinea pig hearts. The time required to produce the greatest positive inotropic response was 28 min in 15-day- to 6-month-old guinea pig hearts and 20 min in 18–24-month-old guinea pig hearts. To cause arrhythmias and cardiac arrest, 2.1 μmol L−1 ouabain was required in age groups of 15 days to 6 months, and 1.2 μmol L−1 in age groups of 12–24 months. The time of onset of arrhythmias and cardiac arrest was also significantly less in older than in younger animals. Cardiac membranes from 12–24-month-old guinea pig hearts had significantly lower Na+, K+-ATPase activity per mg of sarcolemmal protein and numbers of [3H]ouabain binding sites than those from 28-day- to 6-month-old hearts. The enzyme inhibition by 0.1 μmol L−1 ouabain was, however, less in younger than in older groups. The difference in the inhibition of enzyme was reflected in lower ouabain binding affinity (Kd) in younger animals. The data confirm the existence of an age-related difference in ouabain sensitivity and suggest that these differences may be due to changes in receptor function.
Arthroplastie par implant MiNiMa 1ère génération® dans l'arthrose des articulations inter-phalangiennes distale et proximale des doigts longs : étude rétrospective de 28 cas avec un recul moyen de 3,5 ans

L'implant Minima 1 est un implant en pyrocarbone non contraint, qui agit tel un spacer. L'objectif initial de notre etude est d'evaluer le resultat a long terme de cet implant chez 21 patients representant un total de 28 protheses. L'evaluation des resultats a concerne la mobilite, la douleur, l'existence d'une laxite laterale, la reponse osseuse et la satisfaction du patient. Avec un recul moyen de 3,5 ans, 14 protheses sur 28 restent en place. Le secteur de mobilite en actif des articulations inter-phalangiennes s'echelonne de 10 a 70°, avec une moyenne globale de 24°. La douleur est absente ou occasionnelle chez 78% des patients ayant l'implant en place. 36% des patients sont satisfaits et 27% tres satisfaits. Cette satisfaction ne depend pas de la localisation de l'implant : pour les articulations inter-phalangiennes proximales, la moyenne est de 2,9/5 alors que pour les inter-phalangiennes distales, la moyenne est de 3,75/5. La reponse osseuse aboutit a un remodelage osseux dans 61% des cas. La complication majeure est la luxation laterale des implants. L'instabilite frontale, liee a l'incompetence des ligaments collateraux, est retrouvee dans 40% des poses, et represente 86% des causes de re-intervention. Les reprises chirurgicales surviennent dans 50% des arthroplasties. Les complications sont retrouvees majoritairement sur les articulations inter-phalangiennes des doigts radiaux. Ces resultats sont inferieurs a ceux retrouves dans la litterature, notamment un arc de mobilite moindre et un taux de reprise chirurgicale superieur. La pose de cet implant en pyrocarbone n'empeche pas la realisation ulterieure d'une arthrodese ou d'une arthroplastie.