Miracle-dz/UniFAR-FTUs huggingface dataset:
Monoamine Oxidase Inhibitor Switching Strategies: No Adverse Events Associated With Outpatient Cross-taper or Inpatient Rapid Switch.

score = 4). Thus, amisulpride, a benzamide antipsychotic with a low risk of neurological symptoms, was chosen (dose up to 600 mg/d). A substantial recovery of RLS was observed after 2 weeks (IRLS score = 16), along with improvement of psychotic symptoms (PANSS total score = 40: positive score = 7, negative score = 14, general psychopathology score = 19). Interestingly, the patient stopped amisulpride for 3 days (because of bacterial conjunctivitis that she attributed to her treatment), leading to a worsening of RLS (IRLS score = 31). Restless legs syndrome improved after the reintroduction of amisulpride (400 mg/d) and recovered completely after one more week of treatment (IRLS score = 1). Of note, the anticholinergic drug tropatepine (20 mg/d) was prescribed during 4 days to treat acute dystonia related to risperidone treatment. No effect on RLS was observed. Benzodiazepine treatments were also used during hospitalization to treat acute anxiety symptoms. No change in RLS symptoms intensity was observed during introduction, dosage decrease, or benzodiazepine withdrawal. The positive effect of amisulpride on RLS was unexpected; however, its specific pharmacodynamic profile could explain this effect. First, the amisulpride effect on D2 receptors depends on its dose and concentration; it is a D2 receptor antagonist at high concentrations and a dopaminergic D2 agonist in low concentrations (explained by presynaptic action on D2/D3 autoreceptors). Second, amisulpride has antidopaminergic effects selectively in the mesolimbic area (leading to antipsychotic effects), whereas it could have dopaminergic agonist effects in the other areas including spinal area. Third, spinal prodopaminergic effects induce antinociceptive effects in RLS. So it could make sense that amisulpride, via dopaminergic agonist effects in the spinal area, could improve RLS. Because the improvement of RLS with amisulpride was unexpected, we did not systematically conduct polysomnography or suggested immobilization test before and after treatment. These tests could be useful to assess periodic limb movements during sleep and wake (frequently associated with RLS) and to add more precision in the assessment of RLS severity and outcome after treatment. So we recommend to perform these tests for future patients with RLS before and after initiation of amisulpride treatment. This case report is relevant because the RLS prevalence in patients with schizophrenia treated with antipsychotics is doubled, as compared with healthy controls. It suggests that amisulpride could be a useful antipsychotic medication for patients with schizophrenia and RLS.
Achieving a Successful Closure of an Anterior Tympanic Membrane Perforation: Evidence-Based Systematic Review

Objectives Surgical repair of a tympanic membrane perforation is a common otologic procedure. However, achieving a successful closure can be challenging, especially if the anterior margin of the tympanic membrane is involved. The aim of this study was to systematically review the literature on evidence published in closure of anterior tympanic membrane perforations. Data Sources The following data sources were searched: Cochrane Central Register of Controlled Trials (1997 to August, 3 2017), MEDLINE (February 1948 to August 3, 2017), and Embase (1975 to August 3, 2017). Data Extraction Two authors independently reviewed titles and abstracts. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines were followed. For the purpose of this study, the inclusion criteria were as follows; (1) studies reporting surgical technique for closure of anterior tympanic membrane perforations, (2) primary cases only, (3) articles published in the English language, (4) minimum 6-month follow-up, and (5) recorded pre- and postoperative audiometry. The exclusion criteria were non–English language articles, revision surgery, and no audiometric outcomes. Results On initial search, a total of 181 articles were identified (PubMed, n = 136; Cochrane, n = 28; Embase, n = 17). Based on the criteria, 136 articles were excluded. Full text of 45 articles was reviewed, and a further 24 articles were excluded. A total of 21 articles fulfilled the criteria for study inclusion. Conclusions All published evidence is level 4. High-quality controlled studies are required to determine the most effective method for closure of anterior tympanic membrane perforation.
A switching buck converter with dual loop controller and segmented output stage with improved start-up and transient response

In this paper, a method is presented to improve the transient response of a buck converter. This method is based on using dual-loop voltage-mode controller along with a segmented power transistor stage. The first control loop is a conventional voltage-mode feedback using a second order delta-sigma as the control block. The second loop controls the size of the switches during the transient time. Simulation results in a 0. 18μm CMOS technology confirm that by applying this technique, output-voltage overshoot at start-up almost disappears and settling time decreases by 50%. The output settling time during the load current steps is also improved by up to 50%.
Methicillin-Resistant and -Susceptible Staphylococcus aureus Sequence Type 398 in Pigs and Humans

Methicillin-resistant Staphylococcus aureus sequence type 398 (ST398 MRSA) was identified in Dutch pigs and pig farmers. ST398 methicillin-susceptible S. aureus circulates among humans at low frequency (0.2%) but was isolated in 3 human cases of bacteremia (2.1%; p = 0.026). Although its natural host is probably porcine, ST398 MRSA likely causes infections in humans.
Reduced Radiative Conductivity of Low-Spin (Mg,Fe)O in the Lower Mantle

Optical absorption spectra have been measured at pressures up to 80 gigapascals (GPa) for the lower-mantle oxide magnesiowüstite (Mg,Fe)O. Upon reaching the high-spin to low-spin transition of Fe2+ at about 60 GPa, we observed enhanced absorption in the mid- and near-infrared spectral range, whereas absorption in the visible-ultraviolet was reduced. The observed changes in absorption are in contrast to prediction and are attributed to d-d orbital charge transfer in the Fe2+ ion. The results indicate that low-spin (Mg,Fe)O will exhibit lower radiative thermal conductivity than high-spin (Mg,Fe)O, which needs to be considered in future geodynamic models of convection and plume stabilization in the lower mantle.
Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males

Consumption of caffeine-rich beverages, which have diuretic properties, may decrease serum uric acid concentrations. We examined cross-sectionally the relationship of coffee and green tea consumption to serum uric acid concentrations in 2240 male self-defence officials who received a pre-retirement health examination at four hospitals of the Self-Defence Forces between 1993 and 1994. The mean levels of coffee and green tea consumption were 2·3 and 3·1 cups/d respectively. There was a clear inverse relationship between coffee consumption and serum uric acid concentration. When adjusted for hospital only, those consuming less than one cup of coffee daily had a mean serum uric acid concentration of 60 mg/l, while that of those drinking five or more cups of coffee daily was 56 mg/l (P < 0·0001). No such relationship was observed for green tea, another major dietary source of caffeine in Japan. The relationship between coffee consumption and serum uric acid concentration was independent of age, rank in the Self-Defence Forces, BMI, systolic blood pressure, serum creatinine, serum total cholesterol and serum HDL-cholesterol concentrations, smoking status, alcohol use, beer consumption and intake of dairy products. These findings suggest that coffee drinking may be associated with lower concentrations of serum uric acid, and further studies are needed to confirm the association.
Green virtual network embedding framework based on zooming small cells in Fiber-Wireless access network for 5G

The converged Fiber-Wireless (FiWi) access network that can provide service to users with a high capacity, flexibility and reliability has become a promising “last mile” solution for the Fifth Generation (5G). Network virtualization is capable of shielding the heterogeneous features of physical networks and facing the emergence of Over the top (OTT) content, which is consistent with the vision of 5G, where energy efficiency is one of the key issues. This paper concerns the green virtual network embedding scheme in virtualized FiWi access network for 5G, where the zooming small cell is designed. On one hand, the energy can be saved by decreasing the transmitting power of Small cell Base Stations (SBSs) reasonably. On the other hand, the virtual node embedding can be optimized through zooming the coverage of small cells and the zero-loaded SBSs can be switched into sleep state for energy-saving.
Vegetation Changes in the Permafrost Regions of the Qinghai-Tibetan Plateau from 1982-2012: Different Responses Related to Geographical Locations and Vegetation Types in High-Altitude Areas

The Qinghai-Tibetan Plateau (QTP) contains the largest permafrost area in a high-altitude region in the world, and the unique hydrothermal environments of the active layers in this region have an important impact on vegetation growth. Geographical locations present different climatic conditions, and in combination with the permafrost environments, these conditions comprehensively affect the local vegetation activity. Therefore, the responses of vegetation to climate change in the permafrost region of the QTP may be varied differently by geographical location and vegetation condition. In this study, using the latest Global Inventory Modeling and Mapping Studies (GIMMS) Normalized Difference Vegetation Index (NDVI) product based on turning points (TPs), which were calculated using a piecewise linear model, 9 areas within the permafrost region of the QTP were selected to investigate the effect of geographical location and vegetation type on vegetation growth from 1982 to 2012. The following 4 vegetation types were observed in the 9 selected study areas: alpine swamp meadow, alpine meadow, alpine steppe and alpine desert. The research results show that, in these study areas, TPs mainly appeared in 2000 and 2001, and almost 55.1% and 35.0% of the TPs were located in 2000 and 2001. The global standardized precipitation evapotranspiration index (SPEI) and 7 meteorological variables were selected to analyze their correlations with NDVI. We found that the main correlative variables to vegetation productivity in study areas from 1982 to 2012 were precipitation, surface downward long-wave radiation and temperature. Furthermore, NDVI changes exhibited by different vegetation types within the same study area followed similar trends. The results show that regional effects rather than vegetation type had a larger impact on changes in vegetation growth in the permafrost regions of the QTP, indicating that climatic factors had a larger impact in the permafrost regions than the environmental factors (including permafrost) related to the underlying surface conditions.
Reticella: An Execution Trace Slicing and Visualization Tool Based on a Behavior Model

SUMMARY Program comprehension using dynamic information is one of key tasks of software maintenance. Software visualization with sequence diagrams is a promising technique to help developer comprehend the behavior of object-oriented systems e ﬀ ectively. There are many tools that can support automatic generation of a sequence diagram from execution traces. However it is still di ﬃ cult to understand the behavior because the size of automatically generated sequence diagrams from the massive amounts of execution traces tends to be beyond developer’s capacity. In this paper, we propose an execution trace slicing and visualization method. Our proposed method is capable of slice calculation based on a behavior model which can treat dependencies based on static and dynamic analysis and supports for various programs including exceptions and multi-threading. We also introduce our tool that perform our proposed slice calculation on the Eclipse platform. We show the applicability of our proposed method by applying the tool to two Java programs as case studies. As a result, we con-ﬁrm e ﬀ ectiveness of our proposed method for understanding the behavior of object-oriented systems.
The effect of multiple analysers on the biochemical diagnosis of myocardial infarction using a contemporary troponin–I assay

Background The measurement of cardiac troponin is central for the diagnosis of myocardial infarction (MI). It is recommended that a coefficient of variation of ≤10% is achieved at the diagnostic threshold and significant change between serial measurements reported. Many modern laboratories use multiple analysers linked by automation where samples are randomly assigned to an analyser. It is therefore important to consider the combined effect of all analysers on the analytical performance of troponin measurement. Method The performance of a contemporary troponin-I (cTn-I) assay run on three analysers, linked by an automated track, was undertaken across a range of cTn-I concentrations. The data for the three analysers were aggregated to obtain the combined analytical coefficient of variation (CVA) and reference change values (RCVs). Results The CVA improved with increasing concentration and calculated RCVs ranged from 67.2% (±13 ng/L) to 32% (±160 ng/L) between cTn-I values 20 ng/L and 500 ng/L. Although there were significant differences in cTn-I measurement between analysers around the diagnostic threshold (P < 0.05), the CVA was 13.6%. Conclusions We demonstrate that there are significant differences between the performances of analysers which can impact the biochemical criteria for the diagnosis of MI. We also show that the RCV varies according to baseline cTn-I values and that reporting a single RCV across the analytical range of cTn-I may not be appropriate.
Assessing the Relationship Between Topography and Plant Diversity in Restored and Remnant Wet Prairies

Wet prairies provide numerous ecosystem services and habitat for native plant species. The relationship between microtopographic variation and plant diversity in six restored and remnant wet prairies was examined in the West Eugene Wetlands to aid future restoration projects. It was predicted that variation in elevation is influential in determining native plant community composition. Along transects within previously established macroplots, soil surface elevation and water depth were measured and percent cover of grasses, forbs, and non-forbs, and measured vegetation and litter height were determined. A linear regression was performed comparing native species richness to the topographic coefficient of variation which yielded an R2 value of 0.43 and a p-value of 0.16. Although the results are not statistically significant, they demonstrate a meaningful correlation between native plant richness and the coefficient of variation of topography. Further observations additionally suggest that this relationship is present. We suggest further research to determine significant results and suggest the integration of the restoration of microtopography into wetland management.
A new method for imaging perfusion and contrast extraction fraction: Input functions derived from reference tissues

This study describes a new method for analysis of dynamic MR contrast data that greatly increases the time available for data acquisition. The capillary input function, CB(t), is estimated from the rate of contrast agent uptake in a reference tissue such as muscle, based on literature values for perfusion rate, extraction fraction, and extracellular volume. The rate constant for contrast uptake (the product of perfusion rate, F, and extraction fraction, E; F‐E) is then determined in each image pixel using CB(t), extracellular volume (relative to the reference tissue) measured from MR and the tissue concentration of contrast media as a function of time calculated from the MR data. The “reference tissue method” was tested using rats with mammary (n = 10) or prostate (n = 15) tumors implanted in the hindlimb. Dynamic MR images at 4.7 T were acquired before and after Gd‐DTPA intravenous bolus injections to determine F·EGd‐DTPA. Acquisition parameters were optimized for detection of the first pass of the contrast agent bolus, so that “first‐pass analysis” could be used as the “gold standard” for determination of F·E. The accuracy of values of F·E determined using the reference tissue method was determined based on comparison with first‐pass analysis. In some cases, deuterated water (D2O) was injected IV immediately after Gd‐DTPA measurements, and the reference tissue method was used to calculate F, based on the rate of uptake of D2O. Comparison of rate constants for Gd‐DTPA uptake and D2O uptake allowed calculation of EGd‐DTPA. Values for F·EGd‐DTPA, F, and EGd.DTPA were determined for selected regions and on a pixel‐by‐pixel basis. Values for F·E and EGd.DTPA measured using the reference tissue method correlated well (P = .90 with a standard error of ±.016, n = 15) with values determined based on first‐pass contrast media uptake. The reference tissue method has important advantages: (a) A large volume of reference tissue can be used to determine the contrast agent input function with high precision. (b) Data obtained for 20 minutes after injection are used to calculate F or F·E. The greatly increased acquisition time can be used to increase the spatial resolution, field of view or SNR of measurements. The reference tissue method is most useful when the volume of tissue that must be imaged and/or the spatial resolution required precludes use of traditional first‐pass methods.
Detección temprana de la demencia: la perspectiva neuropsicológica

Reflexion RESUMEN Los limites entre el deterioro cognoscitivo y el envejecimiento normal y entre ellos y la demencia, aun no se han establecido claramente. La heterogeneidad de las manifestaciones, la progresion de los sintomas clinicos propios en uno y otra han complicado la distincion, no solo del limite entre lo normal y patologico, sino del componente cognoscitivo comprometido. Mas alla de si el deterioro cognoscitivo marca un lindero entre el envejecimiento normal y el patologico, se hace necesaria una adecuada identificacion de si ello involucra solo la memoria, u otras areas cognoscitivas. El deterioro cognoscitivo leve (MCI) de tipo amnesico, evoluciona hacia Enfermedad de Alzheimer (EA), el multidominio hacia EA y hacia demencia vascular y el MCI no amnesico, lo hace mas hacia las demencias fronto-temporales o vasculares. La neuropsicologia la estandarizado y validado diversas pruebas en espanol que permiten una correcta identificacion del envejecimiento, del deterioro cognoscitivo y de las diversas formas clinicas de la demencia. PALABRAS CLAVES. Pruebas neuropsicologicas, Demencia, Deterioro cognoscitivo, Demencia fronto-temporal. Enfermedad de Alzheimer.
Isolation enhancement of two closely spaced planar monopole antennas for industrial, scientific, and medical applications

This paper presents a simple yet very effective decoupling mechanism based on the insertion of two adjacent planar monopole rectangular patch antennas separated by λo/62. The array achieves a total realized gain of 3.48 dB (exciting one port) and 4.78 dB (exciting two ports), a relative bandwidth of 49 % ( 2 - 3.3 ) GHz over which the matching level |S21| is less than -10 dB and a coupling level |S21| is below or equal to -20 dB. The antenna array offers radiation pattern diversity for different port excitation situation. The gain, decoupling level, radiation pattern diversity, and relatively compact size offered by the proposed antenna provides a good candidate to be implemented in modern wireless communication devices including, but not limited to, systems utilizing the ISM band.
Case management and assertive community treatment in Europe.

OBJECTIVE Case management studies from Europe and the United States continue to yield conflicting results. At a symposium at the World Psychiatric Conference in Hamburg in 1999, researchers from four European countries explored the possible reasons for differences in outcome. They also examined reasons for the differing foci of case management studies across the different cultures. The authors summarize the symposium's findings. METHODS Individual case presentations were given of studies and services from the United Kingdom (three studies), Sweden (two studies), Germany, and Italy (one each). Outcomes, methodologies, and national service context were examined. RESULTS AND CONCLUSIONS A significant influence of national culture is evident both in the acceptability of case management and in approaches to researching it. Case management is perceived as an "Anglophone import" in Italy but is now national policy for persons with severe mental illness in the other three countries. Studies from the United Kingdom emphasized methodological rigor, with little attention to treatment content, whereas those from Sweden accepted a less disruptive research approach but with a more prescriptive stipulation of treatment content. Studies from Italy and Germany emphasized the importance of differing descriptive methodologies. Marked differences in the range of social care provision were noted across Europe. Overall, European researchers are less concerned than U.S. researchers with studying the impact of case management on hospital use.
A 5' dystrophin duplication mutation causes membrane deficiency of alpha-dystroglycan in a family with X-linked cardiomyopathy.

5'-mutations in the dystrophin gene can result in cardiomyopathy without clinically-apparent skeletal myopathy. The effect of dystrophin mutations on the assembly and stability of the dystrophin associated protein (DAP) complex in human heart are not fully understood. The molecular defect in the dystrophin complex was explored in a family with an X-linked pedigree and severe dilated cardiomyopathy. Dystrophin gene analysis demonstrated a 5' duplication involving exons 2-7, which encodes the N-terminal actin binding domain of dystrophin. Ribonuclease protection and PCR assays demonstrated a reduction in muscle promoter transcribed dystrophin mRNA in the heart compared to skeletal muscle. A deficiency of cardiac dystrophin protein was observed by Western blot and lack of membrane localization by immunocytochemistry. The cardiac expression of the dystrophin related protein utrophin was increased, and the 43 kDa (beta-dystroglycan), 50 kDa (alpha-sarcoglycan) and 59 kDa (syntrophin) dystrophin associated proteins (DAPs) were co-isolated and present in nearly normal amounts in the membrane. However, cardiac dystrophin deficiency and increased utrophin expression were associated with loss of extracellular 156 kDa dystrophin associated glycoprotein (alpha-dystroglycan) binding to the cardiomyocyte membrane. alpha-Dystroglycan is responsible for linkage of the dystrophin complex to the extracellular matrix protein laminin. Therefore, 5' dystrophin mutations can reduce cardiac dystrophin mRNA, protein expression, and dystrophin function in X-linked cardiomyopathy (XLCM). The presence of membrane-associated beta-dystroglycan, alpha-sarcoglycan, syntrophin, and utrophin are insufficient to maintain cardiac function. This XLCM family has a 5' dystrophin gene mutation resulting in cardiac dystrophin deficiency and a loss of alpha-dystroglycan membrane binding.