Miracle-dz/UniFAR-FTUs huggingface dataset:
Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

Interleukin 1 (IL-1) plays an important role in host defense mechanisms by increasing body temperature, inducing the synthesis of a variety of lymphokines and hepatic acute phase proteins and acting as a chemoattractant for lymphocytes. However, in some microenvironments such as injured tissue or joint spaces, elevated IL-1 levels may contribute to pathologic processes, for example, proliferation and fibrosis of tissue involved in pannus formation as well as degradation of matrix and abnormal tissue architecture. To investigate potential mechanisms that may lead to excessive production of IL-1, we have examined the ability of IL-1 to participate in an amplification event by inducing its own gene expression leading to synthesis of biologically active IL-1. When injected into rabbits, recombinant human IL-1-alpha induced biphasic fevers, and during the second temperature elevation 3 hr later, a circulating pyrogenic material was detected by passive transfer of plasma to other rabbits. Induction of the biphasic fever was not caused by endotoxin contamination of the recombinant IL-1. The 3-hr circulating pyrogen was heat-labile and was not residual injected IL-1-alpha. Chromatographic separation of this plasma and biologic assay suggested that it was new IL-1 of rabbit origin. We next incubated human blood mononuclear cells with recombinant IL-1-alpha and measured the intracellular and extracellular levels of IL-1 by bioassay using the D10.G4. 1 murine T cell line. In order to control for the carryover of recombinant IL-1-alpha used to stimulate the mononuclear cells (MNC), we used neutralizing antibodies that were specific for IL-1-alpha or IL-1-beta. The results of these neutralizations showed that recombinant human IL-1-alpha induces the synthesis of IL-1-beta in human MNC in vitro. These results were verified with a radioimmunoassay specific for IL-1-beta. At concentrations of 100 ng/ml, IL-1-alpha induced prostaglandin E2 production in the MNC culture, and this was associated with decreased production of immunoreactive IL-1-beta. Adding indomethacin to the cultures prevented the decreased production of IL-1-beta induced by high concentrations of IL-1-alpha. Using nonadherent MNC, we observed an increase in IL-1-beta as well as IL-1-alpha mRNA after 4 hr of exposure to recombinant IL-1-alpha. These results demonstrate that IL-1-alpha induces biologically active and immunoreactive IL-1-beta from MNC in vitro and that the same concentrations of IL-1-alpha induce gene expression for both forms of IL-1. (ABSTRACT TRUNCATED AT 400 WORDS)
Embryonic development in two species of scleractinian coral embryos: Symbiodinium localization and mode of gastrulation

SUMMARY Reef‐building scleractinian corals widely engage in symbiotic relationships with Symbiodinium dinoflagellates (zooxanthellae), which reside inside cells of the gastrodermis. In most cases, sexually produced larvae acquire their symbionts from the environment in the early developmental stages preceding settlement; however, some scleractinian corals maternally “seed” their oocytes with symbionts, and these symbionts are reported to be restricted to the gastrodermis at the time of its formation (gastrulation). A precise mechanism for how Symbiodinium are translocated to endoderm in these seeded species was previously unknown. In order to examine the process of endoderm formation and Symbiodinium localization during gastrulation, we have examined two species of “robust” clade scleractinians: Fungia scutaria (nonseeded) and Pocillopora meandrina (maternally seeded). We determined that both species, independent of whether or not they are seeded, undergo a “nutritive” stage before gastrulation, wherein lipid‐rich cells (F. scutaria) or membrane‐bound cellular fragments (P. meandrina) are passed to the blastocoel where they are subsequently taken up by the definitive endoderm. This emergent property of anthozoan development has been co‐opted to facilitate the movement of Symbiodinium to the blastocoel (future site of endoderm), in the seeded species, where they are later phagocytosed by the newly formed definitive endoderm. Additionally, both species of robust clade scleractinians examined gastrulate by way of invagination, as do the majority of anthozoans. This invagination differs from the prawn chip‐type gastrulation seen in the complex clade corals and provides evidence for a possible linkage between gastrulation type and phylogenetic history.
Epidemiology of Concussions Among United States High School Athletes in 20 Sports

Background: In the United States (US), an estimated 300,000 sports-related concussions occur annually. Among individuals 15 to 24 years of age, sports are second only to motor vehicle crashes as the leading cause of concussions. Purpose: To investigate the epidemiology of concussions in high school athletes by comparing rates and patterns of concussion among 20 sports. Study Design: Descriptive epidemiology study. Methods: Using an Internet-based data collection tool, RIO, certified athletic trainers from a large, nationally disperse sample of US high schools reported athlete exposure and injury data for 20 sports during the 2008-2010 academic years. Results: During the study period, 1936 concussions were reported during 7,780,064 athlete-exposures (AEs) for an overall injury rate of 2.5 per 10,000 AEs. The injury rate was higher in competition (6.4) than practice (1.1) (rate ratio [RR], 5.7; 95% confidence interval [CI], 5.2-6.3). The majority of concussions resulted from participation in football (47.1%, n = 912), followed by girls’ soccer (8.2%, n = 159), boys’ wrestling (5.8%, n = 112), and girls’ basketball (5.5%, n = 107). Football had the highest concussion rate (6.4), followed by boys’ ice hockey (5.4) and boys’ lacrosse (4.0). Concussions represented a greater proportion of total injuries among boys’ ice hockey (22.2%) than all other sports studied (13.0%) (injury proportion ratio [IPR], 1.7; 95% CI, 1.4-2.1; P < .01). In gender-comparable sports, girls had a higher concussion rate (1.7) than boys (1.0) (RR, 1.7; 95% CI, 1.4-2.0). The most common mechanisms of injury were player-player contact (70.3%) and player–playing surface contact (17.2%). In more than 40% of athletes in sports other than girls’ swimming and girls’ track, concussion symptoms resolved in 3 days or less. Athletes most commonly returned to play in 1 to 3 weeks (55.3%), with 22.8% returning in less than 1 week and 2.0% returning in less than 1 day. Conclusion: Although interest in sports-related concussions is usually focused on full-contact sports like football and ice hockey, concussions occur across a wide variety of high school sports. Concussion rates vary by sport, gender, and type of exposure. An understanding of concussion rates, patterns of injury, and risk factors can drive targeted preventive measures and help reduce the risk for concussion among high school athletes in all sports.
Identification of Tyr-397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK

A number of cellular processes, such as proliferation, differentiation, and transformation, are regulated by cell-extracellular matrix interactions. Previous studies have identified a novel tyrosine kinase, the focal adhesion kinase p125FAK, as a component of cell adhesion plaques. p125FAK was identified as a 125-kDa tyrosine-phosphorylated protein in cells transformed by the v-src oncogene. p125FAK is an intracellular protein composed of three domains: a central domain with homology to protein tyrosine kinases, flanked by two noncatalytic domains of 400 amino acids which bear no significant homology to previously cloned proteins. p125FAK is believed to play an important regulatory role in cell adhesion because it localizes to cell adhesion plaques and because its phosphorylation on tyrosine residues is regulated by binding of cell surface integrins to the extracellular matrix. Recent studies have shown that Src, through its SH2 domain, stably associates with pp125FAK and that this association prevents dephosphorylation of pp125FAK in vitro by protein tyrosine phosphatases. In this report, we identify Tyr-397 as the primary in vivo and in vitro site of p125FAK tyrosine phosphorylation and association with Src. Substituting phenylalanine for tyrosine at position 397 significantly reduces p125FAK tyrosine phosphorylation and association with Src but does not abolish p125FAK kinase activity. In addition, p125FAK kinase is able to trans-phosphorylate Tyr-397 in vitro in a kinase-deficient p125FAK variant. Phosphorylation of Tyr-397 provides a site [Y(P)AEI] that fits the consensus sequence for the binding of Src.
Effects of direct renal arterial infusion of bufalin and ouabain in conscious sheep

1 The presence of an endogenous digitalis‐like factor (EDLF) in the plasma of both normal and volume expanded animals is well documented. In this study we have used ouabain and bufalin as pharmacological analogues to mimic the renal effects of EDLF and to investigate whether any interaction occurs between atrial natriuretic factor (ANF) and EDLF. 2 Conscious Na replete sheep with chronically indwelling catheters in the renal artery received renal arterial infusion of ouabain (1000 μg h−1) or bufalin (500 μg h−1) for 60 min. Renal arterial infusion of bufalin increased sodium excretion (UNaV) from 120 ± 13 to 596 ± 161 μmol min−1 after 45 min. Bufalin infusion did not alter glomerular filtration rate (GFR), effective renal plasma flow (ERPF), or lithium clearance. Ouabain infusion increased UNaV from 124 ± 57 to 764 ± 123 μmol min−1 in the first hour after infusion. 3 ANF infusion increased UNaV from 159 ± 34 to 583 ± 134 μmol min−1. When renal arterial bufalin infusion was followed by renal arterial ANF infusion (50 μg h−1) UNaV was increased from 155 ± 31 to 795 ± 96 μmol min−1. This increase in UNaV is approximately equal to the sum of the separate effects of bufalin and ANF. 4 The natriuretic effects of ouabain at pharmacological doses in sheep are confirmed by this study. The data presented here do not support the hypothesis that EDLF sensitizes the kidney to the natriuretic effects of ANF.
Biodegradation of cis-1,4-Polyisoprene Rubbers by Distinct Actinomycetes: Microbial Strategies and Detailed Surface Analysis

ABSTRACT Several actinomycetes isolated from nature were able to use both natural rubber (NR) and synthetic cis-1,4-polyisoprene rubber (IR) as a sole source of carbon. According to their degradation behavior, they were divided into two groups. Representatives of the first group grew only in direct contact to the rubber substrate and led to considerable disintegration of the material during cultivation. The second group consisted of weaker rubber decomposers that did not grow adhesively, as indicated by the formation of clear zones (translucent halos) around bacterial colonies after cultivation on NR dispersed in mineral agar. Taxonomic analysis of four selected strains based on 16S rRNA similarity examinations revealed two Gordonia sp. strains, VH2 and Kb2, and one Mycobacterium fortuitumstrain, NF4, belonging to the first group as well as oneMicromonospora aurantiaca strain, W2b, belonging to the second group. Schiff's reagent staining tests performed for each of the strains indicated colonization of the rubber surface, formation of a bacterial biofilm, and occurrence of compounds containing aldehyde groups during cultivation with NR latex gloves. Detailed analysis by means of scanning electron microscopy yielded further evidence for the two different microbial strategies and clarified the colonization efficiency. Thereby, strains VH2, Kb2, and NF4 directly adhered to and merged into the rubber material, while strain W2b produced mycelial corridors, especially on the surface of IR. Fourier transform infrared spectroscopy comprising the attenuated total reflectance technique was applied on NR latex gloves overgrown by cells of theGordonia strains, which were the strongest rubber decomposers. Spectra demonstrated the decrease in number ofcis-1,4 double bonds, the formation of carbonyl groups, and the change of the overall chemical environment, indicating that an oxidative attack at the double bond is the first metabolic step of the biodegradation process.
Drug Misuse, Dependence and Addiction

Drug addiction presents a chronic relapsing disorder characterized by persistent drug-seeking and taking behaviors. Given the significant detrimental effects of this disease both socially and economically, a considerable research has been dedicated to understanding a number of issues in addiction including behavioral and neuropharmacological factors that contribute to the development of addiction, loss of self control and persistence of compulsive addictive behaviors. This review was designed to list out the drugs and factors which initiate and maintain dependence and how the relapse of these substances occurs in drug dependent persons.
The Cost of Initial Care for Medicare Patients With Advanced Ovarian Cancer.

OBJECTIVES In preparation for payment reform, we evaluated Medicare payments for the initial treatment of patients with advanced ovarian cancer and assessed factors responsible for variation. METHODS Using the linked SEER-Medicare database, we identified a cohort of 9,491 women aged 65 years or older with stage III/IV epithelial ovarian cancer diagnosed between 1995 and 2007. Diagnostic and procedural codes specific to the care of ovarian cancer were used to estimate total medical costs for the treatment of ovarian cancer. Costs were adjusted for geography and for inflation to the 2009 US dollar. NCCN Guideline-consistent care was defined as surgery and 6 cycles of chemotherapy. A generalized linear regression was performed to assess factors associated with variability in cost. RESULTS The mean total payment per patient in the initial treatment period was $65,908 (range of means, $30,745-$96,360). Increasing medical comorbidity, use of PET/CT, surgical complications, and readmissions were associated with increased costs. Treatment with NCCN Guideline-consistent surgery and chemotherapy had a mean annual cost of $85,987 compared with $89,149 for non-NCCN Guideline-consistent treatment with surgery and chemotherapy. The cost of surgery and chemotherapy that was not consistent with NCCN Guidelines was approximately $7,000 more than the cost of therapy that was consistent (P<.001) CONCLUSIONS: The financial burden of caring for patients with ovarian cancer is substantial. Treatment that is consistent with NCCN recommendations for treating advanced ovarian cancer, which is shown to have improved outcomes, is not associated with higher cost.
On combining Websensors and DTW distance for kNN Time Series Forecasting

In the pattern recognition field, different approaches have been proposed to improve time series forecasting models. In this sense, k-Nearest-Neighbour (kNN) with DTW (Dynamic Time Warping) distance is one of the most representative methods, due to its effectiveness, simplicity and intuitiveness. The great advantage of the DTW distance is the robustness to distortions in the time axis by allowing stretching and squeezing (time warping) of the time series, while traditional measures require a linear alignment between each data point. However, as well as other traditional measures, the DTW distance has the limitation of focusing only on historical time series data to predict future values, thereby not considering additional external knowledge of the problem domain. In this paper, we propose an approach called TSFW (Time Series Forecasting with Websensors) that incorporates Websensors into DTW distance to improve kNN time series forecasting. Websensors are models that represent knowledge extracted from news about the problem domain as well as the temporal evolution of this knowledge. In our proposed TSFW approach, we show that Websensors allow a more robust non-linear alignment of the time series by using similar events (extracted from news) that have occurred in the both time series. Thus, distortions in the time axis among the time series can be corrected more accurately compared to the traditional technique that uses only the original values of the time series.
Large effect of membrane tension on the fluid–solid phase transitions of two-component phosphatidylcholine vesicles

Significance Relative to the two-dimensional (temperature–composition) thermodynamic space on which the field of phospholipid membranes has almost exclusively focused, membrane tension represents a third unexplored dimension. We report here that tension has a large qualitative influence, for instance on domain morphology, molecular organization, and multiphase coexistence in thermodynamic space. Relevant to the development of new materials and material confinement, this study demonstrates how switching tension during processing selects morphology on mesoscopic length scales in addition to dictating molecular structure. Separately, although phospholipid rafts in cell membranes are generally considered to be fluid domains that can cluster biomolecules, the current findings demonstrate potential mechanisms for mechanical transduction of membrane structures in cell membranes with low cholesterol content. Model phospholipid membranes and vesicles have long provided insight into the nature of confined materials and membranes while also providing a platform for drug delivery. The rich thermodynamic behavior and interesting domain shapes in these membranes have previously been mapped in extensive studies that vary temperature and composition; however, the thermodynamic impact of tension on bilayers has been restricted to recent reports of subtly reduced fluid–fluid transition temperatures. In two-component phosphatidylcholine unilamellar vesicles [1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)], we report a dramatic influence of tension on the fluid–solid transition and resulting phases: At fixed composition, systematic variations in tension produce differently shaped solid domains (striped or irregular hexagons), shift fluid–solid transition temperatures, and produce a triple-point–like intersection of coexistence curves at elevated tensions, about 3 mN/m for 30% DOPC/70% DPPC. Tension therefore represents a potential switch of microstructure in responsive engineered materials; it is an important morphology-determining variable in confined systems, and, in biological membranes, it may provide a means to regulate dynamic structure.
The organization of immature callosal connections

In newborn kittens, the anterograde transport of horseradish peroxidase, alone or bound to wheat‐germ agglutinin, indicates that callosal axons have entered selectively the restricted portions of the neocortical gray matter (e.g., the area 17/18 border) which receive callosal afferents in adults. The callosal axons do also reach regions where they lack in the adult, but there they seem not to penetrate far into the gray matter.
Learning FOFE based FNN-LMs with noise contrastive estimation and part-of-speech features

A simple but powerful language model called fixed-size ordinally-forgetting encoding (FOFE) based feedforward neural network language models (FNN-LMs) has been proposed recently. Experimental results have shown that FOFE based FNN-LMs can outperform not only the standard FNN-LMs but also the popular recurrent neural network language models (RNN-LMs). In this paper, we extend FOFE based FNN-LMs from several aspects. Firstly, we have proposed a new method to further improve the performance of FOFE based FNN-LMs by adding transitions of part-of-speech (POS) tags as additional features. Secondly, we have investigated how to speedup the learning of FOFE based FNN-LMs by using noise contrastive estimation (NCE). As a result, we can dramatically speedup the learning of FOFE based FNN-LMs while we still achieve very competitive experimental results on Large Text Compression Benchmark (LTCB).
The research for power matching strategy of parallel hybrid vehicle

Power-train is a key component of the parallel electrical hybrid vehicle for which can control energy flow of the system. In this paper, according to the basic configuration of parallel electrical hybrid power-train, the control strategy based on limiting work range of engine is discussed. As a load adjusting device, the motor uptake power and maintain battery working on the range of high efficiency when the system need light torque, otherwise output power to driving system. By using simulation software, the models of engine, clutch, battery, motor, driving system and whole vehicle are established. The results of simulation show that the strategy is available.
Understanding the Provision of Assistive Mobility and Daily Living Devices and Service Delivery to Veterans After Stroke.

OBJECTIVE The objective of this study was to determine whether facility-level, structural factors affect the provision of assistive devices and services. DESIGN A retrospective design was used. Activities of daily living and mobility-related devices were categorized into 11 types. Logistic regression models were performed for each type of device, controlling for patient-level and facility-level covariates. RESULTS Non-veteran-level factors significantly affect the provision of assistive devices, even after covariate adjustment. Increased rehabilitation clinician staffing by 1 full-time equivalent position was associated with increased provision odds of 1%-5% for 5 of 11 types of devices. Lower facility complexity was significantly associated with increased provision odds of 35%-59% for 3 types of devices and with decreased provision odds of 16%-69% for 3 types of devices. CONCLUSION System-level factors, in addition to patient need, significantly affect the provision of assistive devices. Provision guidelines could assist clinicians in making decisions about device provision.
Indeterminate observations (liver imaging reporting and data system category 3) on MRI in the cirrhotic liver: fate and clinical implications.

OBJECTIVE The purpose of this article is to retrospectively evaluate the imaging characteristics and outcomes of indeterminate observations (Liver Imaging Reporting and Data System category 3) detected on MRI in patients with cirrhosis. MATERIALS AND METHODS Sixty-nine indeterminate observations in 52 patients with cirrhosis were imaged with hepatobiliary contrast agent-enhanced MRI. Observations were evaluated retrospectively in terms of the location, size, enhancement pattern, and follow-up results. Each observation was categorized as stable or progressed observations according to serial follow-up MRI. RESULTS The mean follow-up interval was 11.2 months. Forty-six (67%) of the total observations showed arterial enhancement, and 23 (33%) observations showed isointense signal or low signal intensity on arterial phase. The indeterminate observations were classified as arterial enhancement with fade-out appearance (41 observations [59%]), arterial enhancement with washout appearance (five observations [7%]), and nonhyperenhancing observations (23 observations [33%]). Two of 69 observations (3%) were hyperintense on T2-weighted images, and four of 55 observations (7%) were hyperintense on hepatocellular phase. On the final follow-up MRI examinations, four (6%) observations proved to be probable or definite hepatocellular carcinoma, 55 (80%) remained stable, and 10 (14%) decreased in size or were no longer visible. CONCLUSION The most common cause of indeterminate observations on MRI is hypervascular pseudolesions that were clinically stable on follow-up imaging.