Miracle-dz/UniFAR-FTUs huggingface dataset:
Implicit Bank Debt Guarantees: Costs, Benefits and Risks

The expectation by market participants that public authorities might bailout the creditors of banks that are considered too important for financial system stability or another reason to be allowed to fail, is commonly referred to as an implicit guarantee. Public authorities do not have any explicit commitment to intervene; they may even honestly state that they not want to do so ex ante, but may feel compelled to do so ex post. A declared policy aim is to limit the value of implicit guarantees by making banks stronger, more easily resolvable in case of distress, as well as by imposing extra charges that rise as banks become more systemically important. As part of the latter approach, globally systemically important banks are identified and subjected to more costly and intrusive regulation. There is little evidence that specific approach has been successful so far. There is some evidence that the introduction of new resolution frameworks has been helpful, while the use of newly available resolution tools and the involvement of bank creditors in the burden sharing associated with bank failure resolution has significantly reduced the value of implicit bank debt guarantees, where it occurred. In that sense, actions speak louder than words.
Eccentric hamstring strength and hamstring injury risk in Australian footballers.

PURPOSE Are eccentric hamstring strength and between-limb imbalance in eccentric strength, measured during the Nordic hamstring exercise, risk factors for hamstring strain injury (HSI)? METHODS Elite Australian footballers (n = 210) from five different teams participated. Eccentric hamstring strength during the Nordic exercise was obtained at the commencement and conclusion of preseason training and at the midpoint of the season. Injury history and demographic data were also collected. Reports on prospectively occurring HSI were completed by the team medical staff. Relative risk (RR) was determined for univariate data, and logistic regression was employed for multivariate data. RESULTS Twenty-eight new HSI were recorded. Eccentric hamstring strength below 256 N at the start of the preseason and 279 N at the end of the preseason increased the risk of future HSI 2.7-fold (RR, 2.7; 95% confidence interval, 1.3 to 5.5; P = 0.006) and 4.3-fold (RR, 4.3; 95% confidence interval, 1.7 to 11.0; P = 0.002), respectively. Between-limb imbalance in strength of greater than 10% did not increase the risk of future HSI. Univariate analysis did not reveal a significantly greater RR for future HSI in athletes who had sustained a lower limb injury of any kind within the last 12 months. Logistic regression revealed interactions between both athlete age and history of HSI with eccentric hamstring strength, whereby the likelihood of future HSI in older athletes or athletes with a history of HSI was reduced if an athlete had high levels of eccentric strength. CONCLUSION Low levels of eccentric hamstring strength increased the risk of future HSI. Interaction effects suggest that the additional risk of future HSI associated with advancing age or previous injury was mitigated by higher levels of eccentric hamstring strength.
Child mortality in India: The community-level effect of education

When assessing the health benefits of increased education in less developed countries, many researchers have been concerned about the omission of important determinants of an individual’s education from the models. The study presented here shows that one should also be concerned about the limitations of the individual-level perspective. According to a multilevel discrete-time hazard model estimated with data from the National Family Health Survey II, the average education of women in a census enumeration area has a strong impact on child mortality, in addition to the effect of the mother’s own education. The lower child mortality associated with women’s autonomy is taken into account in this estimation. Results from similar models for various health and health-care variables suggest that the effect of community education, like that of individual education, operates through the use of maternity services and other preventive health services, the child’s nutrition, and the mother’s care for a sick child.
Contrasting responses to novelty by wild and captive orangutans

Several studies have suggested that wild primates tend to behave with caution toward novelty, whereas captive primates are thought to be less neophobic, more exploratory, and more innovative. However, few studies have systematically compared captive and wild individuals of the same species to document this “captivity effect” in greater detail. Here we report the responses of both wild and captive orangutans to the same novel items. Novel objects were presented to wild orangutans on multiple platforms placed in the canopy and equipped with motion‐triggered video cameras. The same and different novel objects were also presented to orangutans in two different zoos. The results demonstrate extreme conservatism in both Bornean and Sumatran wild orangutans, who gradually approached the novel objects more closely as they became familiar, but avoided contact with them over many encounters spanning several months. Their zoo‐living conspecifics, in contrast, showed an immediate neophilic response. Our results thus confirm the “captivity effect. ” To the various ecological explanations proposed before (reduced risk and increased time and energy balance for captive individuals relative to wild ones), we add the social information hypothesis, which claims that individuals confronted with novel items preferentially rely on social cues whenever possible. This caution toward novelty disappears when human caretakers become additional role models and can also be eroded when all experience with novelty is positive. Am. J. Primatol. 77:1109–1121, 2015. © 2015 Wiley Periodicals, Inc.
Multi-frame image super-resolution with fast upscaling technique

Multi-frame image super-resolution (MISR) aims to fuse information in low-resolution (LR) image sequence to compose a high-resolution (HR) one, which is applied extensively in many areas recently. Different with single image super-resolution (SISR), sub-pixel transitions between multiple frames introduce additional information, attaching more significance to fusion operator to alleviate the ill-posedness of MISR. For reconstruction-based approaches, the inevitable projection of reconstruction errors from LR space to HR space is commonly tackled by an interpolation operator, however crude interpolation may not fit the natural image and generate annoying blurring artifacts, especially after fusion operator. In this paper, we propose an end-to-end fast upscaling technique to replace the interpolation operator, design upscaling filters in LR space for periodic sub-locations respectively and shuffle the filter results to derive the final reconstruction errors in HR space. The proposed fast upscaling technique not only reduce the computational complexity of the upscaling operation by utilizing shuffling operation to avoid complex operation in HR space, but also realize superior performance with fewer blurring artifacts. Extensive experimental results demonstrate the effectiveness and efficiency of the proposed technique, whilst, combining the proposed technique with bilateral total variation (BTV) regu-larization, the MISR approach outperforms state-of-the-art methods.
Incidence of spontaneous post-implantation deaths in CFT-Swiss mice: its suitability to assess dominant lethal mutations

The primary objective of the study was to determine the incidence of spontaneous post-implantation deaths (DI) in our randomly-bred closed colony of CFT-Swiss mice. These data are required mainly to ascertain the suitability of the strain for their use in dominant lethal (DL) mutation assays, a well validated in vivo mammalian germ cell assay. To achieve the first goal, randomly drawn healthy adult males were sequentially mated to adult virgin females (1:2 ratio) for a period of 8 weeks. Male-based analysis of the 3 major variables viz., implantations, live embryos, and dead implants (DI) were carried out. Absence of outliers and low variation in spontaneous DI, as well as the other variables associated with DL assay were observed in all matings. Secondly, the degree of induction of DI were studied following administration (i.p.) of an acute dose of ethyl methane sulphonate (EMS). EMS induced nearly a 5-fold increase in the mduring the first 2 weeks and a 3-fold during the third week suggesting its DL-type effect only in specific post-meiotic stages of spermatogenesis as reported earlier.
Oral Glutamine Supplementation Protects Female Mice from Nonalcoholic Steatohepatitis.

BACKGROUND Genetic factors, a diet rich in fat and sugar, and an impaired intestinal barrier function are critical in the development of nonalcoholic steatohepatitis (NASH). The nonessential amino acid glutamine (Gln) has been suggested to have protective effects on intestinal barrier function but also against the development of liver diseases of various etiologies. OBJECTIVE The effect of oral Gln supplementation on the development of Western-style diet (WSD)-induced NASH in mice was assessed. METHODS Female 6- to 8-wk-old C57BL/6J mice were pair-fed a control (C) diet or a WSD alone or supplemented with 2.1 g l-Gln/kg body weight for 6 wk (C+Gln or WSD+Gln). Indexes of liver damage, lipid peroxidation, and glucose metabolism and endotoxin concentrations were measured. RESULTS Although Gln supplementation had no effect on the loss of the tight junction protein occludin, the increased portal endotoxin and fasting glucose concentrations found in WSD-fed mice, markers of liver damage (e.g., nonalcoholic fatty liver disease activity score and number of neutrophils in the liver) were significantly lower in the WSD+Gln group than in the WSD group (~47% and ~60% less, respectively; P < 0.05). Concentrations of inducible nitric oxide synthase (iNOS) protein and 3-nitrotyrosin protein adducts were significantly higher in livers of WSD-fed mice than in all other groups (~8.6- and ~1.9-fold higher, respectively, compared with the C group; P < 0.05) but did not differ between WSD+Gln-, C-, and C+Gln-fed mice. Hepatic tumor necrosis factor α and plasminogen activator inhibitor 1 concentrations were significantly higher in WSD-fed mice (~1.6- and ~1.8-fold higher, respectively; P < 0.05) but not in WSD+Gln-fed mice compared with C mice. CONCLUSION Our data suggest that the protective effects of oral Gln supplementation on the development of WSD-induced NASH in mice are associated with protection against the induction of iNOS and lipid peroxidation in the liver.
Analysis of Human Metapneumovirus and Human Bocavirus Viral Load

Viral load (VL) of human metapneumovirus and human bocavirus in infants <12 months admitted for bronchiolitis was analyzed. VL correlated with length of hospital stay in both viruses, human metapneumovirus VL with the duration oxygen therapy and human bocavirus VL inversely with days of respiratory effort before admission. Infants coinfected by other viruses were younger, but no differences were seen regarding VL.
Romancing the rural: Reconceptualizing rural entrepreneurship as engagement with context(s)

This article considers how we conceive and research rural entrepreneurship. While we argue for the importance of context for understanding entrepreneuring, we also acknowledge that some perceptions of the rural context may be misleading. We critically review how the rural in rural entrepreneurship has been applied. We find how some romancing of the rural has had detrimental effects in theorizing about rural. However, we also find and discuss the interesting range of relationships between the rural and the entrepreneurship presented in the literature. We conclude that a conceptually robust approach can be achieved by examining the nature and extent of entrepreneurial engagement with the contexts that characterize the rural. Finally, we propose methods that will enable us to achieve better understanding of the processes of rural.
A Diffusible Factor from Arbuscular Mycorrhizal Fungi Induces Symbiosis-Specific MtENOD11 Expression in Roots ofMedicago truncatula 1

Using dual cultures of arbuscular mycorrhizal (AM) fungi andMedicago truncatula separated by a physical barrier, we demonstrate that hyphae from germinating spores produce a diffusible factor that is perceived by roots in the absence of direct physical contact. This AM factor elicits expression of the Nod factor-inducible gene MtENOD11, visualized using a pMtENOD11-gusA reporter. Transgene induction occurs primarily in the root cortex, with expression stretching from the zone of root hair emergence to the region of mature root hairs. All AM fungi tested (Gigaspora rosea,Gigaspora gigantea, Gigaspora margarita, and Glomus intraradices) elicit a similar response, whereas pathogenic fungi such as Phythophthora medicaginis, Phoma medicaginis var pinodella andFusarium solani f.sp. phaseoli do not, suggesting that the observed root response is specific to AM fungi. Finally, pMtENOD11-gusA induction in response to the diffusible AM fungal factor is also observed with all threeM. truncatulaNod−/Myc− mutants (dmi1,dmi2, and dmi3), whereas the same mutants are blocked in their response to Nod factor. This positive response of the Nod−/Myc− mutants to the diffusible AM fungal factor and the different cellular localization of pMtENOD11-gusA expression in response to Nod factor versus AM factor suggest that signal transduction occurs via different pathways and that expression of MtENOD11 is differently regulated by the two diffusible factors.
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

Significance Mutations or inactivation of parkin causes Parkinson’s disease (PD) in humans. Recent studies have focused on parkin’s role in mitochondrial quality control in the pathogenesis of PD, including defects in mitophagy, mitochondrial fission, fusion, and transport. This study shows that parkin also controls mitochondrial biogenesis and that defects in mitochondrial biogenesis drive the loss of dopamine (DA) neurons due to the absence of parkin. The findings support the role of parkin in regulating multiple arms of mitochondrial quality control and suggest that maintaining mitochondrial biogenesis is critically important in the survival of DA neurons. Mutations in parkin lead to early-onset autosomal recessive Parkinson’s disease (PD) and inactivation of parkin is thought to contribute to sporadic PD. Adult knockout of parkin in the ventral midbrain of mice leads to an age-dependent loss of dopamine neurons that is dependent on the accumulation of parkin interacting substrate (PARIS), zinc finger protein 746 (ZNF746), and its transcriptional repression of PGC-1α. Here we show that adult knockout of parkin in mouse ventral midbrain leads to decreases in mitochondrial size, number, and protein markers consistent with a defect in mitochondrial biogenesis. This decrease in mitochondrial mass is prevented by short hairpin RNA knockdown of PARIS. PARIS overexpression in mouse ventral midbrain leads to decreases in mitochondrial number and protein markers and PGC-1α–dependent deficits in mitochondrial respiration. Taken together, these results suggest that parkin loss impairs mitochondrial biogenesis, leading to declining function of the mitochondrial pool and cell death.
Suppression of matrix metalloproteinase production from synovial fibroblasts by meloxicam in‐vitro

The aim of this study was to evaluate the influence of meloxicam on the production of both matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) from human synovial fibroblasts by TNF‐α stimulation in‐vitro. Synovial fibroblasts (2 times 104 cells/mL) derived from patients with osteoarthritis were stimulated with 20.0 ng mL−1 TNF‐α in the presence of various concentrations of meloxicam. After 24 h, the culture supernatants were obtained and assayed for MMP‐1, MMP‐2, MMP‐3, MMP‐13, TIMP‐1 and TIMP‐2 by ELISA. mRNA expression for MMPs and TIMPs in 4‐h‐cultured cells were examined by real‐time polymerase chain reaction. Transcriptional factor (NF‐κB and AP‐1) activation in 2‐h‐cultured cells was also examined by ELISA. Meloxicam could suppress MMP production in a dose‐dependent manner. The minimum concentration of the agent that showed significant suppression was 0.6 times 10−6 m for MMP‐1, MMP‐2 and MMP‐3, and 1.3 times 10−6 m for MMP‐13. The ability of synovial fibroblasts to produce TIMPs was also suppressed by meloxicam as in the case of MMP production. Addition of meloxicam into synovial fibroblast cultures inhibited dose‐dependently mRNA expression for MMPs and TIMPs, which were increased by TNF‐α stimulation, through the suppression of NF‐κB and AP‐1 activation. The suppressive effect of meloxicam on the production of MMPs and TIMPs may partly be involved in attenuation of the clinical conditions of osteoarthritis and rheumatoid arthritis.
Three Somatic Genetic Biomarkers and Covariates in Radiation-Exposed Russian Cleanup Workers of the Chernobyl Nuclear Reactor 6–13 Years after Exposure

Abstract Jones, I. M. , Galick, H. , Kato, P., Langlois, R. G. , Mendelsohn, M. L. , Murphy, G. A. , Pleshanov, P., Ramsey, M. J., Thomas, C. B. , Tucker, J. D. , Tureva, L. , Vorobstova, I. and Nelson, D. O. Three Somatic Genetic Biomarkers and Covariates in Radiation-Exposed Russian Cleanup Workers of the Chernobyl Nuclear Reactor 6–13 Years after Exposure. Radiat. Res. 158, 424–442 (2002). Three somatic mutation assays were evaluated in men exposed to low-dose, whole-body, ionizing radiation. Blood samples were obtained between 1992 and 1999 from 625 Russian Chernobyl cleanup workers and 182 Russian controls. The assays were chromosome translocations in lymphocytes detected by FISH, hypoxanthine phosphoribosyltransferase (HPRT) mutant frequency in lymphocytes by cloning, and flow cytometic assay for glycophorin A (GPA) variant frequency of both deletion (N/Ø) and recombination (N/N) events detected in erythrocytes. Over 30 exposure and lifestyle covariates were available from questionnaires. Among the covariates evaluated, some increased (e.g. age, smoking) and others decreased (e.g. date of sample) biomarker responses at a magnitude comparable to Chernobyl exposure. When adjusted for covariates, exposure at Chernobyl was a statistically significant factor for translocation frequency (increase of 30%, 95% CI of 10%–53%, P = 0.002) and HPRT mutant frequency (increase of 41%, 95% CI of 19%–66%, P < 0.001), but not for either GPA assay. The estimated average dose for the cleanup workers based on the average increase in translocations was 9.5 cGy. Translocation analysis is the preferred biomarker for low-dose radiation dosimetry given its sensitivity, relatively few covariates, and dose–response data. Based on this estimated dose, the risk of exposure-related cancer is expected to be low.
Exploring formal mentoring relationships in a nascent entrepreneurial context: functions, interactions, emotions, behaviour, and agency

Formal mentoring programmes are an important support available to nascent entrepreneurs during venture formation, emergence and growth. This form of support has received little theoretical or empirical attention in the entrepreneurship and mentoring literature. Given that an entrepreneur or entrepreneurial team is the primus inter pares of emerging, growing, and established ventures, the development of the venture is intertwined with the competence and capability of the entrepreneur(s). To advance scholarship on formal nascent entrepreneurial mentoring relationships, this research reviews existing entrepreneurship and mentoring literature, and links social support theory to this research context. The literature review provides insight into five areas that remain under researched in the context of nascent entrepreneur and mentoring, namely, functions, interactions, emotions, behaviour and entrepreneurial agency, and as a result a multilevel model of nascent entrepreneurial mentoring is proposed and utilised as a foundation for the empirical research. An analysis of the research is provided including implications for research, policy and practice. This thesis makes a number of theoretical, conceptual, and empirical contributions. It proposes a multilevel model of the entrepreneur-mentor relationship highlighting the multiple contexts that impact the relationship, and a model of the relationship between emotions and entrepreneurial agency. Finally, it explores the positive emotions derived through functions and mentor interactions reinforce particular behaviours that can enhance dimensions of entrepreneurial agency.
[Diagnostic value of heart fatty-acid binding protein in early hospitalized patients with non ST elevation acute coronary syndrome].

BACKGROUND Heart fatty-acid-binding protein (FABP) is supposed to be the most sensitive biomarker of myocardial necrosis in patients with Q-wave myocardial infarction (MI) and non-diagnostic ECG during first hours after onset of symptoms. However, diagnostic value of FABP in patients with non-ST elevation acute coronary syndrome (NSTEACS) is not well established. AIM To elucidate diagnostic value of FABP in patients with NSTEACS hospitalized within time interval considered to be too early for a majority of biochemical tests. MATERIAL AND METHODS FABP levels were measured by immunofluorometry (HyTest, Finland) in 44 patients (26 men, mean age 69+/-8.9 years) at admission within 6 hours (median - 2 h) from onset of index attack of angina and in 6, 12, 24 hours after onset of pain. Cut off FABP level was 12 ng/ml. Serum cardiac troponin I was measured for diagnosis of MI on admission and twice during first 24 hours of hospital stay. Cut off TnI level was 0.4 ng/ml. RESULTS Acute MI was diagnosed by TnI above cut off in 31 patients (70.5%). There were no new-Q-wave MIs. Average ratio of observed serum FABP level to diagnostic cut off value on admission and in 6, 12, 24 hours after onset of pain was higher in patients with MI than in patients with unstable angina (1.01, 1.53, 0.81, 0.66 and 0.78, 0.51, 0.65, 0.56, respectively). The difference was maximally significant in 6 hours after onset of pain (p=0.018). Among patients with MI admission FABP compared with admission TnI more frequently exceeded diagnostic level (in 18 vs 9 patients, respectively, p=0.009). Sensitivity and specificity of admission levels of FABP and TnI for diagnosis of MI were 58 and 85%, 29% and 100%, respectively. CONCLUSION In patients with NSTEACS during first 6 hours after pain onset FABP compared with TnI has greater sensitivity for detection of MI and sufficient specificity. FABP can be used as additional diagnostic tool for MI detection in early admitted patients with NSTEACS.
Polarity in nanoscale in PbZrxSn1−xO3 single crystals

In this work, the temperature dependencies of local piezo- and electrostrictive repsonse in single PZS crystals were measured by means of PEFM method and compared with a bulk responses. The local piezoelectric activity in the paraelectric phase measured in nanoscale, together with the observation of weak birefringence, are the direct proof for local lattice instability in wide temperature range (~50K) above Tc. Analysis of these features is a way to understand better the phase transition mechanisms in oxidic perovskites with antiferroelectric phase transition. In addition to expected non-homogeneous distribution of the Sn ions, discussed is important influence of the extended defects and other crystal inhomogeneities on the local electrostricitive and piezoelectric activities observed.