Miracle-dz/UniFAR-FTUs huggingface dataset:
Do climate engineering experts display moral-hazard behaviour?

ABSTRACT Discourse analyses and expert interviews about climate engineering (CE) report high levels of reflectivity about the technologies’ risks and challenges, implying that CE experts are unlikely to display moral hazard behaviour, i.e. a reduced focus on mitigation. This has, however, not been empirically tested. Within CE experts we distinguish between experts for radiation management (RM) and for carbon dioxide removal (CDR) and analyse whether RM and CDR experts display moral hazard behaviour. For RM experts, we furthermore look at whether they agree to laboratory and field research, and how they perceive the risks and benefits of one specific RM method, Stratospheric Aerosol Injection (SAI). Analyzing experts’ preferences for climate-policy options, we do not find a reduction of the mitigation budget, i.e. moral hazard, for RM or CDR experts compared to climate-change experts who are neither experts for RM nor for CDR. In particular, the budget shares earmarked for RM are low. The perceptions of risks and benefits of SAI are similar for RM and climate-change experts. Despite the difference in knowledge and expertise, experts and laypersons share an understanding of the benefits, while their perceptions of the risks differ: experts perceive the risks to be larger. Key policy insights Experts surveyed all prioritize mitigation over carbon dioxide removal and in particular radiation management. In the views of the experts, SAI is not a viable climate policy option within the next 25 years, and potentially beyond, as global field-testing (which would be a precondition for long-term deployment) is widely rejected. In the case of SAI, greater knowledge leads to increased awareness of the uncertainty and complexity involved. Policy-makers need to be aware of this relationship and the potential misconceptions among laypersons with limited knowledge, and should follow the guidelines about communicating risks and uncertainties of CE that experts have been advised to follow.
Cannabis, from plant to pill

The therapeutic application of cannabis is attracting substantial public and clinical interest. The cannabis plant has been described as a veritable ‘treasure trove’, producing more than 100 different cannabinoids, although the focus to date has been on the psychoactive molecule delta‐9‐tetraydrocannabinol (THC) and cannabidiol (CBD). Other numerous secondary metabolites of cannabis, the terpenes, some of which share the common intermediary geranyl diphosphate (GPP) with the cannabinoids, are hypothesized to contribute synergistically to their therapeutic benefits, an attribute that has been described as the ‘entourage effect’. The effective delivery of such a complex multicomponent pharmaceutical relies upon the stable genetic background and standardized growth of the plant material, particularly if the raw botanical product in the form of the dried pistillate inflorescence (flos) is the source. Following supercritical CO2 extraction of the inflorescence (and possibly bracts), the secondary metabolites can be blended to provide a specific ratio of major cannabinoids (THC : CBD) or individual cannabinoids can be isolated, purified and supplied as the pharmaceutical. Intensive breeding strategies will provide novel cultivars of cannabis possessing elevated levels of specific cannabinoids or other secondary metabolites.
Clinical predictors of early fluoxetine treatment response in obsessive–compulsive disorder

Despite wide use, relatively little is known about sociodemographic and clinical characteristics that predict early fluoxetine response. What research has been conducted has produced inconsistent findings, which may be due to the statistical procedures used, and no studies to date have examined predictors of early fluoxetine treatment response. Sixty adults with obsessive–compulsive disorder (OCD) completed an open‐label fluoxetine trial for 8 weeks (up to 40 mg) after a 1‐week, single‐blind, placebo run‐in before baseline assessment. The baseline and posttreatment assessment battery included the Yale–Brown Obsessive Compulsive Scale, the Hamilton Rating Scale for Depression, and the Yale Global Tic Severity Scale. Patient characteristics included illness duration, age, age of onset, gender, and pharmacological treatment history. Independent t‐tests and multiple logistic regression analysis showed that longer illness duration, older age, and greater symptom severity were associated with nonresponse. Our findings highlight the impact of functional psychiatric impairment on determining those who may respond to treatment. Furthermore, findings suggest early predictors of patients with certain characteristics who may ultimately need adjunctive care to facilitate response. Depression and Anxiety 23:429–433, 2006. Published 2006 Wiley‐Liss, Inc.
Evidence for a Leptin-Neuropeptide Y Axis for the Regulation of Growth Hormone Secretion in the Rat

The obese gene (OB) product, leptin, has been shown to exert control on metabolic processes such as food intake and body weight homeostasis, possibly through a neuropeptide Y (NPY) neurotransmission. More recently, leptin has been shown to control several neuroendocrine axes, modulating pituitary hormone secretions in function of metabolic conditions. Since in the rat growth hormone (GH) secretion is dependent upon prevailing metabolic conditions, and NPY has been shown to be implicated in the feedback mechanisms of this hormone, we reasoned that leptin could also exert control over GH secretion and we examined this hypothesis in male rats submitted to a 3-day fast. Circulating leptin concentrations measured by RIA abruptly fell to low values after 24 h of fasting and remained low thereafter. Upon refeeding, leptin secretion regularly increased. As shown by others, pulsatile GH secretion had disappeared after 3 days of fasting. Centrally administered leptin (10 µg/day, i.c.v. infusion initiated at the beginning of the fasting period) totally prevented the disappearance of pulsatile GH secretion. No leak of centrally administered leptin to the general circulation was observed. Infusing the same amount of leptin intracerebroventricularly to rats receiving ad libitum feeding produced a severe reduction in food intake but maintained a normal GH secretory pattern. In contrast, pair-fed rats, submitted to the same food restriction, exhibited a marked reduction in GH secretion. Hypothalamic NPY gene expression, estimated by Northern blot analysis, was significantly increased in fasting rats, and decreased in leptin-treated, fasting rats. In rats receiving ad libitum feeding, leptin treatment reduced NPY gene expression, consistent with the observed reduction in food intake, whereas pair-fed animals logically exhibited increased NPY gene expression. In both situations with reduced feeding, normal GH secretion was seen in leptin-treated animals exhibiting low NPY gene expression, whereas decreased or abolished GH secretion was seen in animals not receiving leptin and exhibiting increased NPY mRNA levels. Interestingly, despite maintenance of normal GH secretion in leptin-treated, fasting rats, plasma IGF-I levels were low, as in vehicle-treated rats. Indeed, hepatic gene expression for both GH receptor and IGF-I was markedly reduced by fasting, and no correction was seen with leptin treatment. In summary, the regulation of GH secretion, at least the changes linked with malnutrition, appears to be dependent upon a leptin signal, perceived centrally, possibly related to circulating levels of this new hormone. The present data suggest that leptin can rescue normal pulsatile GH secretion by preventing the documented inhibitory action of NPY on GH secretion.
A new approach to migrations: communities-on-the-move as assets

ABSTRACT This paper proposes a novel interpretive framework for studying migration and its implications in terms of innovation, entrepreneurship and regional development. We suggest that migration patterns and their impact should be analyzed through the lens of communities on the move (CoM): cultural communities marked by their own social capital, that is, shared values and network ties, which provide tacit knowledge and opportunities to their members and facilitate their integration in their host regions and countries. CoM have a strong influence on migrants' well-being and their capacity to produce innovation and entrepreneurial impact that promote the development of the host regions.
Design of pole placement power system stabilizer for SMIB-effect of operating conditions

This paper presents the design of pole placement approach used in association with power system stabilizer for single machine infinite bus (SMIB). The performance of the scheme is enhanced by appropriately placing the poles at desired locations. The experiments are conducted for full operating conditions light, normal and heavy loads. The effect of operating conditions (types of load) on the proposed controller has been discussed. The proposed scheme is implemented implemented using MATLAB/SIMULINK platform
Heritability and genetic integration of tooth size in the South Carolina Gullah.

OBJECTIVES This article provides estimates of narrow-sense heritability and genetic pleiotropy for mesiodistal tooth dimensions for a sample of 20th century African American individuals. Results inform biological distance analysis and offer insights into patterns of integration in the human dentition. MATERIALS AND METHODS Maximum mesiodistal crown dimensions were measured using Hillson-FitzGerald calipers on 469 stone dental casts from the Menegaz-Bock Collection. Narrow-sense heritability estimates and genetic and phenotypic correlations were estimated using SOLAR 8.1. 1 with covariate screening for age, sex, age*sex interaction, and birth year. RESULTS Heritability estimates were moderate (∼0.10 - 0.90; h2 mean = 0.51) for most measured variables with sex as the only significant covariate. Patterns of genetic correlation indicate strong integration across tooth classes, except molars. Comparison of these results to previously published work suggests lower overall heritability relative to other human populations and much stronger genetic integration across tooth classes than obtained from nonhuman primate genetic pleiotropy estimates. CONCLUSIONS These results suggest that the high heritabilities previously published may reflect overestimates inherent in previous study designs; as such the standard estimate of 0.55 used in biodistance analyses may not be appropriate. For the Gullah, isolation and endogamy coupled with elevated levels of physiological and economic stress may suppress narrow-sense heritability estimates. Pleiotropy analyses suggest a more highly integrated dentition in humans than in other mammals.
Sonotubometric measurement of the eustachian tube function by means of band noise. A clinical view of the acoustic measurement of the eustachian tube.

The Eustachian tube is well known as an organ serving the ventilation and drainage of the tympanic cavity and mastoid. Ventilation is carried out by the opening and closing of the Eustachian tube accompanying swallowing movements. Until now there has been no instrument to quantify these motor activities of the tube necessary for its function as a ventilator. The author developed a generally applicable sonotubometer Model WIO-01 with the help of Siemens Hearing Institute K.K. for automatic measurement of the aforesaid tubal function with the use of 7 kHz full-octave band noise. In a sonotubometric trial with 32 adult female subjects, the duration of patency of the Eustachian tube was 288.5 +/- 1.38. 5 ms, and the amplitude eliciting response was 16.4 +/- 8.3 dB. The positive response rate was 89.1%. In 89 children aged 4-12 years, a positive response was detected in 117 ears (61.9%). The mean duration of patency was 337.7 +/- 154.4 ms, and the amplitude 16.3 +/- 7.2 dB. It is physiological to have tubal opening and closing during natural swallowing. It is therefore important to understand the tubal function when dealing with tympanoplasty and diseases caused by tubal dysfunction.
Key‐genes regulating the liposecretion process of mature adipocytes

White mature adipocytes (MAs) are plastic cells able to reversibly transdifferentiate toward fibroblast‐like cells maintaining stem cell gene signatures. The main morphologic aspect of this transdifferentiation process, called liposecretion, is the secretion of large lipid droplets and the development of organelles necessary for exocrine secretion. There is a considerable interest in the adipocyte plastic properties involving liposecretion process, but the molecular details are incompletely explored. This review analyzes the gene expression of MAs isolated from human subcutaneous fat tissue with respect to bone marrow (BM)‐derived mesenchymal stem cells (MSC) focusing on gene regulatory pathways involved into cellular morphology changes, cellular proliferation and transports of molecules through the membrane, suggesting potential ways to guide liposecretion. In particular, Wnt, MAPK/ERK, and AKT pathways were accurately described, studying up‐ and down‐stream molecules involved. Moreover, adipogenic extra‐ and intra‐cellular interactions were analyzed studying the role of CDH2, CDH11, ITGA5, E‐Syt1, PAI‐1, IGF1, and INHBB genes. Additionally, PLIN1 and PLIN2 could be key‐genes of liposecretion process regulating molecules transport through the membrane. All together data demonstrated that liposecretion is regulated through a complex molecular networks that are able to respond to microenvironment signals, cytokines, and growth factors. Autocrine as well as external signaling molecules might activate liposecretion affecting adipocytes physiology.
In vivo study of cerebral ischemia using Shear Wave Imaging and Ultrafast Doppler

A multi-modal ultrasound imaging study of cerebral ischemia was performed on a rat model. Ischemia was obtained by the transient 2h occlusion of a cerebral artery and the lesion induced was imaged 1, 2, 4 and 7 days after the stroke. With Bmode imaging, the lesion was found to be hyperechogenic compared to normal brain tissue. With Shear Wave Imaging, the elasticity of the brain was measured showing that the ischemic lesion is softer than normal brain tissue and that its elasticity decreases significantly over time. With Ultrafast Doppler, the perfusion in the brain was measured showing that the lesion is hyperperfused compared to normal brain tissue with a peak two days after the occlusion. Ultrafast Doppler was also proved able to monitor the occlusion. Future work will focused on applying this multi-modal study for ischemic lesions induced by apoxia on newborn babies through the fontanel.
Electrochemical phase diagrams of Ni from ab initio simulations: role of exchange interactions on accuracy

The stabilities of Ni metal and its derived compounds, including oxides, hydroxides, and oxyhydroxides under electrochemical conditions, can be readily predicted from the Ni Pourbaix diagram, where the formation free energies of the involved species are utilized to construct the phase stability map with respect to electrode potential and pH. We calculate and analyze the crystal structures, electronic structures, and thermodynamic energies of Ni metal and its compounds using different exchange-correlation functionals to density-functional-theory (DFT), including the semilocal LDA and GGA density functionals, the nonlocal metaGGA, and the hybrid density functionals. Next, we simulate the corresponding Ni Pourbaix diagrams to compare systematically the performance of the functional to each other and to experimental observations. We show that the structures and energies obtained from experimental databases may not be sufficiently accurate to describe direct electrochemical observations, and we explain how the electronic exchange within the density functionals plays a key role in determining the accuracy of the DFT calculated electronic, thermodynamic, and electrochemical properties. We find that only the hybrid density functional produces reliable results owing to the fractional contribution of exact Fock exchange included therein. Last, based on our accurate Ni Pourbaix diagram, we construct band-gap and magnetic electrochemical maps which can facilitate more experimental measurements and property assessments under variable potential and pH in the future.
E-Cigarettes and Future Cigarette Use

BACKGROUND: There has been little research examining whether e-cigarette use increases the risk of cigarette initiation among adolescents in the transition to adulthood when the sale of cigarettes becomes legal. METHODS: The Children’s Health Study is a prospectively followed cohort in Southern California. Data on e-cigarette use were collected in 11th and 12th grade (mean age = 17.4); follow-up data on tobacco product use were collected an average of 16 months later from never-smoking e-cigarette users at initial evaluation (n = 146) and from a sample of never-smoking, never e-cigarette users (n = 152) frequency matched to e-cigarette users on gender, ethnicity, and grade. RESULTS: Cigarette initiation during follow-up was reported by 40.4% of e-cigarette users (n = 59) and 10.5% of never users (n = 16). E-cigarette users had 6.17 times (95% confidence interval: 3.30–11.6) the odds of initiating cigarettes as never e-cigarette users. Results were robust to adjustment for potential confounders and in analyses restricted to never users of any combustible tobacco product. Associations were stronger in adolescents with no intention of smoking at initial evaluation. E-cigarette users were also more likely to initiate use of any combustible product (odds ratio = 4.98; 95% confidence interval: 2.37–10.4), including hookah, cigars, or pipes. CONCLUSIONS: E-cigarette use in never-smoking youth may increase risk of subsequent initiation of cigarettes and other combustible products during the transition to adulthood when the purchase of tobacco products becomes legal. Stronger associations in participants with no intention of smoking suggests that e-cigarette use was not simply a marker for individuals who would have gone on to smoke regardless of e-cigarette use.
Tiliqua scincoides: Temperature-Sensitive Units in Lizard Brain

Extracellular action potentials were recorded from units in the preoptic area of the brain of the Australian blue-tongued skink (Tiliqua scincoides) during periods of local heating and cooling of the brain (20� to 36�C) with water-perfused thermodes. In this temperature range most spontaneously firing neurons were temperature-insensitive, but eight showed sensitivity to the thermal stimulus. Five warm neurons increased their activity when the brain temperature was raised, and three cold neurons showed increased activity with fall in temperature.
Two Distinct Binding Sites for High Potential Iron-Sulfur Protein and Cytochrome c on the Reaction Center-bound Cytochrome of Rubrivivax gelatinosus*

The photosynthetic cyclic electron transfer of the purple bacterium Rubrivivax gelatinosus, involving the cytochrome bc1 complex and the reaction center, can be carried out via two pathways. A high potential iron-sulfur protein (HiPIP) acts as the in vivo periplasmic electron donor to the reaction center (RC)-bound cytochrome when cells are grown under anaerobic conditions in the light, while cytochrome c is the soluble electron carrier for cells grown under 8aerobic conditions in the dark. A spontaneous reversion of R. gelatinosus C244, a defective mutant in synthesis of the RC-bound cytochrome by insertion of a Kmr cassette leading to gene disruption with a slow growth rate, restores the normal photosynthetic growth. This revertant, designated C244-P1, lost the Kmr cassette but synthesized a RC-bound cytochrome with an external 77-amino acid insertion derived from the cassette. We characterized the RC-bound cytochrome of this mutant by EPR, time-resolved optical spectroscopy, and structural analysis. We also investigated the in vivo electron transfer rates between the two soluble electron donors and this RC-bound cytochrome. Our results demonstrated that the C244-P1 RC-bound cytochrome is still able to receive electrons from HiPIP, but it is no longer reducible by cytochrome c8. Combining these experimental and theoretical protein-protein docking results, we conclude that cytochrome c8 and HiPIP bind the RC-bound cytochrome at two distinct but partially overlapping sites.
Effect of continuous positive airway pressure on sleep structure in heart failure patients with central sleep apnea.

STUDY OBJECTIVES At termination of obstructive apneas, arousal is a protective mechanism that facilitates restoration of upper airway patency and airflow. Treating obstructive sleep apnea (OSA) by continuous positive airway pressure (CPAP) reduces arousal frequency indicating that such arousals are caused by OSA. In heart failure (HF) patients with central sleep apnea (CSA), however, arousals frequently occur several breaths after apnea termination, and there is uncertainty as to whether arousals from sleep are a consequence of CSA. If so, they should diminish in frequency when CSA is attenuated. We therefore sought to determine whether attenuation of CSA by CPAP reduces arousal frequency. DESIGN Randomized controlled clinical trial. PATIENTS AND SETTING We examined data from 205 HF patients with CSA (apnea-hypopnea index [AHI] > or =15, > 50% were central) randomized to CPAP or control who had polysomnograms performed at baseline and 3 months later. MEASUREMENTS AND RESULTS In the control group, there was no change in AHI or frequency of arousals. In the CPAP-treated group, the AHI decreased significantly (from [mean +/- SD] 38.9 +/- 15.0 to 17.6 +/- 16.3, P < 0.001) but neither the frequency of arousals nor sleep structure changed significantly. CONCLUSION These data suggest that attenuation of CSA by CPAP does not reduce arousal frequency in HF patients. We conclude that arousals were not mainly a consequence of CSA, and may not have been acting as a defense mechanism to terminate apneas in the same way they do in OSA.
Inequalities in the reduction of child stunting over time in Latin America: evidence from the DHS 2000–2010

Abstract This article analyses the evolution of child stunting in seven Latin American countries during the 2000s, based on repeated cross-sections of Demographic and Health Surveys (DHS). The incidence of stunting differs from country to country, ranging from 27% in the Plurinational State of Bolivia to 6% in Brazil. The largest reduction in stunting took place in Peru, where it declined from 28% in 2007 to 18% in 2012. The decrease in Haiti is also noteworthy, from 29% in 2006 to 21% in 2012. Although all countries were able to reduce the incidence of child stunting, inequalities in child stunting evolved differently. Whereas in Brazil and Colombia inequality in child stunting decreased, in Peru and Bolivia it rose. In the rest of the countries, improvements in child stunting took place jointly with no statistically significant change in its inequality. Results from the decomposition analysis indicate that the unequal distribution in stunting is accounted mainly by the wealth index, and to a lesser extent, by maternal characteristics such as weight, education, and children ever born. Factors such as breastfeeding and diarrhoea exert smaller effects. In all countries, inequality in wealth was the main contributor to changes in stunting inequality, with equalizing or un-equalizing effects depending on the country.