Miracle-dz/UniFAR-FTUs huggingface dataset:
2D or 3D? How cell motility measurements are conserved across dimensions in vitro and translate in vivo

Abstract Cell motility is a critical aspect of several processes, such as wound healing and immunity; however, it is dysregulated in cancer. Current limitations of imaging tools make it difficult to study cell migration in vivo. To overcome this, and to identify drivers from the microenvironment that regulate cell migration, bioengineers have developed 2D (two‐dimensional) and 3D (three‐dimensional) tissue model systems in which to study cell motility in vitro, with the aim of mimicking elements of the environments in which cells move in vivo. However, there has been no systematic study to explicitly relate and compare cell motility measurements between these geometries or systems. Here, we provide such analysis on our own data, as well as across data in existing literature to understand whether, and which, metrics are conserved across systems. To our surprise, only one metric of cell movement on 2D surfaces significantly and positively correlates with cell migration in 3D environments (percent migrating cells), and cell invasion in 3D has a weak, negative correlation with glioblastoma invasion in vivo. Finally, to compare across complex model systems, in vivo data, and data from different labs, we suggest that groups report an effect size, a statistical tool that is most translatable across experiments and labs, when conducting experiments that affect cellular motility.
Noncommutative Gerbes

We review the construction of the Seiberg-Witten map (SW map) from commutative to noncommutative gauge theories. We then consider it in the global context of line bundles and thus recall the definition of noncommutative line bundles. We show how to glue togheter noncommutative bundles and thus define noncommutative gerbes. Examples arising from deformation quantization of twisted Poisson structures are presented.
The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation

Background According to existing related experiments and research reports, stem cell transplantation therapy has been shown to have a positive effect on the recovery of liver fibrosis/cirrhosis, but for some reason, this therapy still cannot be widely used in clinical work. One of the reasons that cannot be ignored is the low quantity of exogenous stem cells transplanted into the liver in vivo. Thus, we investigated whether the use of the vascular endothelial growth factor (VEGF) can increase the number of stem cell transplants and improve the efficacy of stem cell transplantation therapy. Methods Using a Sprague-Dawley rat liver fibrosis model, we transplanted into fibrosis liver allograft bone marrow mesenchymal stem cells (BMSCs) which were labelled with chlormethylbenzamido-1,1-dioctadecyl-3,3,3′3′-tetramethylin-docarbocyamine (CM-DiI) or injected VEGF adenovirus solution through the tail vein or conducted the above two operations simultaneously. The cell surface receptor profile of BMSC was examined by flow cytometry and immunofluorescence staining. Hepatic sinusoidal vascular leakage was measured with Evan's blue dye assay. Paraffin section staining, immunofluorescent staining, RT-qPCR (quantitative reverse transcription polymerase chain reaction), and Western blot were used to evaluate hepatic pathological changes and physiology function. Result The in vivo study indicated that, comparing with other groups of rats, the rats with combined treatment of BMSC transplantation and VEGF injection exhibited obvious reduction in liver fibrosis. Evan's blue dye assay suggests that after injecting with VEGF adenovirus solution, the rat's hepatic sinusoidal permeability would be increased. We confirmed the expression of very late antigen-4 (VLA4, integrin α4β1) on rat BMSCs and the elevated expression of vascular adhesion molecule-1 (VCAM-1) in the hepatic sinusoidal endothelial cells. In addition, the analysis of CM-DiI-labeled BMSCs showed that the BMSC+VEGF group exhibited better cell engraftment and that the engrafted cells were mainly distributed in the hepatic parenchyma. Furthermore, compared with the other situation, it is best to reconstitute the liver secretion and regeneration function of rats after combined application of VEGF and BMSC. Conclusion We showed that VEGF promotes the engraftment of BMSCs in liver fibrosis, enhances liver regeneration, and improves liver function. These outcomes may be related to the increasing hepatic sinusoidal endothelium permeability and VCAM-1-increased expression.
PRODUCTION OF BIODEMULSIFIER BY PSEUDOMONAS ALCALIGENES AND BACILLUS SUBITILLIS STRAINS USING CASSAVA WASTEWATER AND PARAFFIN AS CARBON SOURCES

In the oil drilling processes the emulsion formed by the water and the oil must be broken with the use of demulsifiers, in order to reduce the corrosion problems in pipes and equipment arising from impurities present in the produced water; furthermore, the excess water in the emulsified crude oil increases the costs of transport to refineries. Bacteria with demulsification capability is an innovative solution on the demulsification of a W/O emulsion or an O/W emulsion, due to the low toxicity, biodegradability and high efficiency in extreme conditions. The biodemulsifiers produced by strains of P. alcaligenes and Bacillus subtilis and employing using as carbon alternative source effluent from the pressing of cassava root, represents a promising approach for the production of demulsifiers; also reducing the discard of this effluent in the environment. Superficial tension properties and strains of microbial growth were analyzed during the process of production of the biodemulsifier. The demulsification ratios obtained were 50% (p Alcaligenes) and 57.5% (subitilis Bacillus).
Foot loading in normal and pathological walking

Perttunen, Jarmo Foot Loading in Normal and Pathological Walking Jyvaskyla: University of Jyvaskyla, 2002, 86 p. (Studies in Sport, Physical Education and Health, ISSN 0356-1070; 83) ISBN 951-39-1222-1 Finnish summary Diss. The present series of studies was designed to study the interaction between foot loading patterns and neuromusculoskeletal adaptation during normal and pathological walking. The behaviour of the foot was examined in healthy subjects and different groups of patients. In order to know how surgical intervention affected the ability to walk, foot loading patterns and neuromusculoskeletal function was studied before and after corrective surgery. Special emphasis was laid on understanding the benefits of corrective surgery. The test procedure for the Paromed-System used in the present study showed that it could be used accurately to examine the bilateral symmetry of foot loading during walking without any disturbance to the subject. The highest peak plantar pressures were found under the heel, the first metatarsal and the big toe in both the normal and patient groups. The results suggested that foot loading asymmetry did not increase at faster walking speeds in healthy subjects. However, patients with limb length discrepancy and patients recovering from tibial fracture had excessive foot loading asymmetries, which tended to become greater at fast walking speeds. The peak plantar pressures usually increased under the foot in the healthy subjects when walking speed increased while decreasing under the lateral forefoot. In contrast to this medial shift, bilateral comparison showed that the plantar pressures under the operated foot after free-flap reconstruction of the tibial fractures had shifted more to the lateral side of the forefoot. This lateralisation was a compensatory mechanism to reduce the loading on the ankle joint. The results from the triple jump showed that the high lateral forefoot pressure and maximal vertical ground reaction force in the braking phase and maximal horizontal ground reaction force in the anterior-posterior direction in the push-off phase were closely correlated to the length of the triple jump. In patients the foot loading and muscle strength symmetry improved notably during the follow-up after the reconstruction surgery to correct the limb length discrepancy. Because symmetry after the different surgical interventions was not completely restored, long rehabilitation period is needed after corrective surgery.
Fractals of Stress Experience at Air Traffic Controllers

Introduction: The present study is rooted in the desire of finding suitable solutions for the aggravating forms of stress. Beyond the harsh reality of powerful stress factors, there is our desire for recovery and adequate use of personal resources. This is not a simple task at all, and in order to do this we should first identify our personal resources. Objectives: The objectives of the study were to study the interaction between the personality factors and the fractals of occupational stress among air traffic controllers and the Optimization of stress adjustment mechanisms among air traffic controllers and the development of the premises necessary for adopting a lifestyle based on an efficient coping. Methods: The instruments used are: the Perceived Stress Scale, the Freiburg Personality Inventory, the Holmes Scale, and the Coping Scale. The subjects have been asked to answer individually to the samples that have been applied, with no time limit. For each group of subjects, the sample application has been performed inside the institution in which they usually worked. The sample consisted of 90 individuals, all air traffic controllers, with a mean age of m=38.2. It is important to point out that the study refers only to en-route air traffic controllers and due to the low number of women working in this domain, the gender variable has not been taken into consideration. Furthermore, the study compares the results obtained for the air traffic controllers working in Arad and those working in other regions of Romania. Results: Results have shown that the prolonged presence of stressful factors in the case of the groups subjected to study, has led to negative effects for all five categories that have been taken into consideration: influence on personality, cognitive effects, influence on health, influence on behaviour and physiological effetcs. Conclusions: By identifying the dimension of our reaction to stress, some of our adequate possibilities to react and some of our personal resources, we can take a step forward towards participating with more openness and enthusiasm in the interventions that occur in the case of
Person Identification and Authentication via Ultrasound Hand-gesture-signature Analysis

Biometrics showed their usefulness in several applications, systems with fingerprint or face identification are well accepted in several fields with possibly different constraints like, for example, forensic or smartphone unlocking. In this paper, a novel ultrasound prototype for person identification and authentication has been designed, built and tested. The system, which acts as a sonar, measures the pressure wave backscattered from a moving hand. Such signal is subsequently processed by means of time/frequency analysis and a deep learning detector is implemented in order to identify/authenticate the user based on some peculiarity in the gestures execution. The proposed solution is cheap and, due to the high adaptability, allows different security levels. Promising results are obtained after tests carried out with the help of 10 volunteers.
Demonstration of a WART in a hybrid zone of the common shrew (Sorex araneus Linnaeus, 1758)

Among common shrews from the hybrid zone between the Moscow and Seliger chromosomal races, we found an adult male characterised by two metacentrics not found in either race (hm, nq). These metacentrics apparently arose by a wholearm reciprocal translocation (WART) of two of the Seliger metacentrics (hn, mq). Although such rearrangements have been postulated previously to explain racial differences, this is the first direct evidence of a WART in the common shrew. Apart from the unusual metacentrics, the karyotype of the male shrew was that of an F1 hybrid, i.e. this individual was a complex heterozygote that formed a chain-of-11 configuration at meiosis. Regular synapsis was demonstrated at pachytene, complete configurations were scored at diakinesis, and mature sperm were observed within the meiotic preparations.
Ryser's Conjecture under eigenvalue conditions

We prove the nonexistence of a circulant Hadamard matrix $H$ of order $n$, under technical conditions on the eigenvalues of $H$, when $n$ has only two odd prime divisors and in the general case. Main tool are appropriate properties of the $n$-th cyclotomic polynomial.
Study of Malaria Vectors Density Using Artificial Breeding Container in Yola-South L.G.A of Adamawa State

Mosquitoes are vectors for many pathogens with catastropic effects on global heath. A total of 1806 mosquitoes were sampled from earthen pots and examined under a microscope. Distribution of malaria vectors density by sites of location revealed that Mbamba Mission had a total malaria vector density distribution of 0.47(27.98%), Mopol Barrack, 0.37(22.02%), Upper Benue Staff Quarters 0.16(9.52%), Rumde Jabbe,0.33(20.00%) and Anguwan Fulani,0.35(20.83%). Mbamba Mission had the highest, malaria vector density while Upper Benue staff Quarters had the lowest. However a statistical analysis showed no significant difference in the distribution of malaria vector density based on location in the study area (p=0.199). Distribution of malaria vectors density according to months revealed that month of July had a total malaria vectors density distribution of 0.65(38.69%), August, 0.68(40.48%) and September, 0.35(20.83%) and there was a significant difference in the distribution of malaria vector density based on months (p=0.047). The distribution of malaria vector density based on their abdominal condition revealed that freshly blood fed malaria vectors had density distribution was 0.48(28.57%), gravid, 0.43(25.59%), half-gravid, 0.46(27.38%) and unblood fed, 0.31(18.45%). However there was no significant difference in the distribution of malaria vector density based on abdominal condition in the study area (p=0.775)
Unappreciated cognitive dysfunction is common among patients hospitalized with cardiovascular disease.

Background: Better understanding of the prevalence of unappreciated cognitive dysfunction among patients with cardiovascular disease during hospitalization is integral to patient-centered care. We tested the hypothesis that there is a substantial prevalence of debilitating cognitive dysfunction in cardiac patients which health care providers do not appreciate. Methods: This observational prospective study evaluated 51 patients on admission to a cardiac intensive care unit (CICU) who did not have a history of conditions known to adversely affect cognition and appeared cognitively intact to treating physicians and nursing staff. Patients Original Research Article Cireddu et al.; BJMMR, 9(12): 1-9, 2015; Article no.BJMMR. 18618 2 underwent neuropsychological testing to assess the domains of global cognition, attention, memory, and executive function at important points during hospitalization. Results: Twenty-six percent of participants were impaired globally based upon the Modified Mini Mental Status Examination. Of the study’s participants, 46% were impaired in memory on short recall and 40% were impaired on long recall based upon Rey Auditory Verbal Learning, while 49% were impaired based upon Digit Span. Further, 38% of participants were impaired in attention based upon Trail Making Test Part A. Twenty-five percent of participants were impaired in executive function based upon Trail Making Test Part B, and 18% were impaired based upon Frontal Assessment Battery. Conclusions: In patients hospitalized with cardiovascular disease, unappreciated cognitive dysfunction is common. The dysfunction involves multiple domains and likely impedes patient participation in longitudinal care and their comprehension of health education which ultimately hinders the transition from hospital to home care. This process creates a setting of poor selfmanagement with significantly increased potential for rehospitalizations.
A hybrid structured deep neural network with Word2Vec for construction accident causes classification

Abstract According to the latest fatal work injury rates reported by the Bureau of Labors Statistics, construction sites remain the most hazardous workplaces. In the construction sector, fatality investigation summary reports are available for past accidents and by investigating such reports, valuable insights can be gained. In this study, text mining algorithms are explored for automatic construction accident causes classification. To be more specific, Word2Vec skip-gram model is utilized to learn word embedding from a domain-specific corpus and a hybrid structured deep neural network is proposed by incorporating the learned word embedding for accident reports classification. Dataset from Occupational Safety and Health Administration (OSHA) is employed in the experiment to evaluate the performance of the proposed approach. Besides, five baseline models: support vector machine (SVM), linear regression (LR), K-nearest neighbor (KNN), decision tree (DT), Naive Bayes (NB) are employed to compare with the proposed approach. Experiment results show that the proposed model achieves the highest average weighted F1 score among all models considered in this study. The result also proves the effectiveness of applying Word2Vec skip-gram algorithm for semantic information augmentation. As a result, robustness of the model is improved when classifying cases of low support values.
Emotion, Respiration, and Heart Rate Variability: A Mathematical Model and Simulation Analyses

Although the generation mechanism of the low-frequency (LF) component of heart rate variability (HRV) is controversial, HRV is a potential candidate in designing objective measurement methodologies for emotions. These methodologies could be valuable for several biosignal applications. Here, we have conducted a simulation analysis using a novel mathematical model that integrates emotion, respiration, the nervous system, and the cardiovascular system. Our model has well reproduced experimental results, specifically concerning HRV with respiratory sinus arrhythmia and LF, the relation between HRV total power and the respiration frequency, and the homeostatic maintenance by the baroreflex. Our model indicates the following possibilities: (i) The delay in the heart rate control process of the parasympathetic activity works as a low-pass filter and the HRV total power decreases with a higher respiration frequency; (ii) the LF component of HRV and the Mayer wave are generated as transient responses of the baroreflex feedback control to perturbations induced by an emotional stimulus; and (iii) concentration on breathing to reduce the respiration frequency can reduce LF/HF and the reduction can be fed back to the emotional status.
INVESTIGATION OF INDOOR ENVIRONMENTAL QUALITY AND PRODUCTIVITY IN MONITORED OFFICES IN SLOVAKIA

Laboratory and field studies show that the physical and chemical factors in the work environment may have a notable impact on the health and comfort of the occupants, and consequently on productivity. There are numerous ways to define productivity. Actually, productivity should be universally defined as the ratio of output to input. A field study was conducted during the heating season in office buildings in Slovakia. A first objective of this study was to determine occurrence level of pollutants in these buildings. A second objective was to evaluate the effect of indoor environmental quality on occupants’ productivity. The quality of indoor climate was also a variable in the analysis. The procedure comprises measurements of indoor environmental parameters, including thermal parameters, concentrations of carbon dioxide, concentrations of total volatile organic compounds, concentrations of particulate matters, acoustic and lighting levels and completion of questionnaires by occupants. Productivity was assessed by method used simulated office tasks. Occupants performed text typing, addition task and symbol – letter task (learning memory test) in experimental offices to evaluate occupants ́ productivity. Subjective experiments were carried out to evaluate the effects of indoor environmental quality on human comfort. The mean mass concentration of particulate matters and noise level were exceeded limit values in the investigated office room 1 (building A). The mean concentration of carbon dioxide and noise level were exceeded recommended and limit values in the office rooms 3 and 4. The mean values of total and correct productivity of all tasks were higher in the investigated building B (offices 3 and 4). Occupants indicated they were uncomfortable with the IAQ.
Selection of Poplar Genotypes for Adapting to Climate Change

Deployment of well-adapted, water use efficient, and productive genotypes may be essential for the sustainability of both forests and wood supply for the forest industry, as climate change is increasing water stress around the world. This study aimed to characterize key traits among new genotypes of hybrid poplars (Populus spp.) in water use efficiency (WUE) and evaluate adaptive capacity to guide the selection of appropriate clones/hybrid types for commercial deployment in habitats with an increasing water deficit in northern, continental climates. Forty-five new hybrid poplar genotypes were compared at the age of 10, including two control clones, Walker and Okanese, growing in a common garden genetics trial in northern Alberta. We studied the relationships between their productivity and WUE, photosynthetic assimilation, transpiration, stomatal conductance, stomatal density and length, and leaf size and weight. In addition, the genetic variance and heritabilities of physiological and morphological characteristics related to WUE were calculated. Results of this study revealed that most of the clones showed an adaptive capacity to acclimatize (small and dense stomata) to the region of deployment. Morphological traits were characterized by higher heritabilities than physiological traits. Hybrids between Populus balsamifera and Populus maximowiczii species showed a slightly greater adaptive potential to the area of our study than the other tested cross types. Walker, a clone widely planted across the Canadian prairies, showed inferior WUE and productivity in comparison to the new genotypes tested. Selection and tree breeding for adaptation to climate change in the region of our investigation identified highly productive genotypes with dense, small stomata and a larger leaf area to dry mass ratio. As these traits are heritable, selection of clones with these traits will ensure a faster reaction of stomata when faced with a water deficit. The low genetic effect, heritability estimates, and high residual effect for physiological traits, impose a severe limitation on the use of gas exchange measurements under field conditions in tree improvement programs selecting for drought resistance.
ENHANCING IMAGE ANNOTATION GAMES BY USING ASIAN WORDNET

ESP and Peekaboom games are successfully done to engage annotators in labelling the images and locating the objects in the images. The advantage of these games is making annotators feel like enjoying a game rather than working hard to label the ton of images. We extended Peekaboom game by introducing Asian WordNet (AWN) to expand the guessed label in terms of its synonym, hypernym, hyponym, meronym, and holonym. The result yields in a higher matched ratio. Moreover, AWN will also provide the semantic link between 13 Asian languages and the English language. Our method also shows a potential in creating cross-language image labelling game.