Miracle-dz/UniFAR-FTUs huggingface dataset:
Controversies Regarding Compatibility in Xenotransfusion With Blood From Dog to Cat (Review)

As it is well known, any incompatible blood transfusion can generate adverse reactions in feline patients, because cats naturally have plasmatic alloantibodies. Even so, recent scientific studies have shown that transfusions with heterologous blood (canine) to cats, were indeed followed by mild hemolysis states, in cases of severely anemic patients. A repeated transfusion however will cause anaphylactic shock with fatal outcome. Based on the data we have studied, we consider xenotransfusion, even though still controversial, to be considered as an emergency therapeutic procedure when superior, homologous blood cannot be acquired for felines. Through this review we hope to offer clinicians the necessary information to consider xenotransfusion as an alternative in emergency therapy, when this is rigorously sustained by blood compatibility tests and when all other options have been excluded only.
Investigating the capacity of dense point cloud photogrammetry to map low rise buildings

The aim of this project was to produce three dimensional dense point cloud data of a low rise building. To achieve this objective, an entry level Canon SLR digital camera was used together with a reasonably priced photogrammetry software package – PhotoScan. The Royal Tasmanian Botanical Gardens Conservatory building was selected to test the capabilities and the limitations of close range photogrammetry. The rugged stone walls and white-painted glass roof as well as the various retaining walls in close proximity, garden beds and upright vegetation set a series of challenges during image capturing. Several dense point cloud models were produced with high spatial resolution. The dense point clouds not only produced visually pleasing images on the screen but the georeferenced points constitute accurate fully three dimensional virtual models of the building and the surrounding area. A dense point cloud contains several millions of points. Each point possesses Easting/Northing and AHD values, several additional attributes and RGB spectral information. The dense point cloud data were stored in the ASPRS LAS format or the highly compressed LAZ binary file format. The LAS file format can be directly read by a wide range of professional and scientific software, therefore many existing methods and tools are available to further process the dense point cloud data. Although this project revolves around the use of digital imagery and PhotoScan photogrammetry software, the Leica Nova MS50 MultiStation was also employed to scan and map the area. MS50 also uses close range photogrammetry in order to assign spectral attributes to the scanned points. The dense point cloud data produced by the laser scanner which proved to be very similar in appearance, was also saved in LAS file format and post processed using the same methods as the point clouds produced using the camera. This project used the basic features of the LAStools and LISCAD software to post process the data of dense point cloud into a familiar format suitable for presentation to building industry professionals. The results of the project proved that it is feasible to map and post process dense point cloud data of man-made structures with the use of common digital camera imagery and readily available photogrammetry software.
Oocyte quality in women with infertility associated endometriosis

Abstract The mechanisms of endometriosis-related infertility remain still unknown. Endometriosis and clinical markers of oocyte quality are a very important problem of reproduction. The purpose of the study is to assess the quality of oocytes in women with infertility associated with endometriosis. The study included infertile reproductive aged women, between 29 and 40 years who underwent IVF and ICSI procedures. The patients were divided into three groups: group I involved 50 (n = 50) patients with recurrent unilateral endometriomas, group II included 50 patients (n = 50) unilateral endometriomas after surgical treatment and control group with 30 (n = 30) patients with tubal factor infertility. Clinical and morphological assessment of oocyte quality was performed in all IVF/ICSI cycles. The results of the study demonstrate a statistically significant increase in the number of immature oocytes of metaphase MI and immature oocytes at the GV germinal vesicle stage in patients with infertility associated with endometriosis, compared with the control group (p<.005). There is deterioration in the quality of the obtained oocytes in patients with the presence of endometrioma more than 3 cm in diameter. The results of this study allow to conclude that endometriomas negatively affect quality of oocyte and ovarian reserve, whereas endometriomas after cystectomy, have a deleterious and sustained effect on ovarian reserve.
325 Exploring the Complexity of Dementia and Loneliness in Ireland

Dementia and loneliness are both complex phenomenon’s that impact on both mental and physical health. Research has identified that loneliness can increase a person’s risk of mortality as much as smoking or alcohol consumption. People with dementia are at particular risk of loneliness and social isolation. This can negatively impact on a person with dementia’s health. To effectively address loneliness in dementia, we must first understand how people with dementia experience loneliness. Interviews were conducted with people living with dementia. Participants comprised of eight community-dwelling individuals, aged 55 years and older (mean = 63.8; range = 55-77), who were each diagnosed with dementia at least one year prior to interview (range = 1.16 – >5 years). Interviews were conducted in participants’ homes using a semi-structured format and lasted between 37-74 minutes. Three key themes emerged: the importance of maintaining meaningful relationships, maintaining independence and socio-cultural influences on individual perceptions of loneliness and dementia. The results emphasise the importance of maintaining both a sense of self and meaningful relationships with others post-diagnosis for individuals who identified themselves as “not lonely”. People living with dementia reported that the maintenance of social connection aids in fostering a sense of self-worth and self-management, which in turn mitigates feelings of loneliness. The majority of participants existing social connections with others was established prior to their diagnosis, although the maintenance of these relationships may have required an adjustment of their premorbid routines and method of social engagement. Human contact and a meaningful relationship are superior in preventing loneliness. Individual feelings of loneliness or lack thereof are not directly correlated to the coping mechanisms most commonly employed by individuals with dementia. Further exploration is need to understand how people with dementia, who live at home, perceive or experience loneliness.
Metabotropic glutamate receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Metabotropic glutamate (mGlu) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Metabotropic Glutamate Receptors [334]) are a family of G protein-coupled receptors activated by the neurotransmitter glutamate. The mGlu family is composed of eight members (named mGlu1 to mGlu8) which are divided in three groups based on similarities of agonist pharmacology, primary sequence and G protein coupling to effector: Group-I (mGlu1 and mGlu5), Group-II (mGlu2 and mGlu3) and Group-III (mGlu4, mGlu6, mGlu7 and mGlu8) (see Further reading). Structurally, mGlu are composed of three juxtaposed domains: a core G protein-activating seven-transmembrane domain (TM), common to all GPCRs, is linked via a rigid cysteine-rich domain (CRD) to the Venus Flytrap domain (VFTD), a large bi-lobed extracellular domain where glutamate binds. The structures of the VFTD of mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 have been solved [190, 262, 255, 386]. The structure of the 7 transmembrane (TM) domains of both mGlu1 and mGlu5 have been solved, and confirm a general helical organization similar to that of other GPCRs, although the helices appear more compacted [85, 415, 59]. mGlu form constitutive dimers crosslinked by a disulfide bridge. Recent studies revealed the possible formation of heterodimers between either group-I receptors, or within and between group-II and -III receptors [86]. Although well characterized in transfected cells, co-localization and specific pharmacological properties also suggest the existence of such heterodimers in the brain [422, 257]. The endogenous ligands of mGlu are L-glutamic acid, L-serine-O-phosphate, N-acetylaspartylglutamate (NAAG) and L-cysteine sulphinic acid. Group-I mGlu receptors may be activated by 3,5-DHPG and (S)-3HPG [29] and antagonized by (S)-hexylhomoibotenic acid [223]. Group-II mGlu receptors may be activated by LY389795 [256], LY379268 [256], eglumegad [337, 416], DCG-IV and (2R,3R)-APDC [338], and antagonised by eGlu [161] and LY307452 [408, 100]. Group-III mGlu receptors may be activated by L-AP4 and (R,S)-4-PPG [125]. An example of an antagonist selective for mGlu receptors is LY341495, which blocks mGlu2 and mGlu3 at low nanomolar concentrations, mGlu8 at high nanomolar concentrations, and mGlu4, mGlu5, and mGlu7 in the micromolar range [176]. In addition to orthosteric ligands that directly interact with the glutamate recognition site, allosteric modulators that bind within the TM domain have been described. Negative allosteric modulators are listed separately. The positive allosteric modulators most often act as ‘potentiators’ of an orthosteric agonist response, without significantly activating the receptor in the absence of agonist.
The Influence of Blood Groups on Diseases Pattern Globally: A Review of Literature

The present survey reports the influence of blood groups on disease pattern in worldwide basis. Genetic factors have been associated with vulnerability or resistance to certain disease. For example, individuals who are heterozygous to haemoglobin S and haemoglobin E are resistant to infection with Plasmodium falciparum. The manifestation of metabolic syndrome, a sickness characterized by multiple risk factors like obesity, hypertension and glucose intolerance is also influenced by genetic and environmental factors. Several studies have established a relationship between ABO blood type and incidences of Plasmodium falciparum infection. This review brought to the fore the relationship between blood groups and susceptibility or resistance to disease. There is need for more studies to be carried out to unravel the exact mechanism how blood groups affect disease. It is recommended that individuals of various blood groups should know the different disease that they are prone to and avoid the predisposing factors to such diseases.
Severe Pulmonary Embolism Following Neglected Trauma of the Lower Limb : Management Difficulties in Resource-Limited Environment

Internal Hospital, Hospital University (HU) of Treichville (RCI) Certifiicate of specialty study anesthesia reanimation Certifiicate of specialty study anesthesia reanimation, Anesthetist, Clinic Manager’s Assistant; UFR –SMA Internal Hospital; Hospital University (HU) of Treichville (RCI) Ph D Certifiicate of specialty study anesthesia reanimation, University Professor, Alasane ouattara Unversity in Bouaké. Bouaké Medical Sciences Training and Research Unit (UFR -SM Bouaké) (Republic of Côted’Ivoire)
Clinical outcomes with endoscopic resection of lumbar extradural cysts.

Background Lumbar extradural cysts may be associated with sciatica-type back and leg pain. The symptoms of clinical pain syndrome from synovial cysts are sometimes difficult to differentiate from those of lumbar disc herniation or spinal canal stenosis and may be identified to be a pain source when visualized endoscopically. The authors analyzed the clinical outcomes with their endoscopic resection to better establish clinical indications and prognosticators of favorable results. Methods Two-year Macnab outcomes, VAS scores, and complications were analyzed in a series of 48 patients treated with the endoscopic removal of extradural cyst encountered during routine transforaminal and interlaminar decompression for foraminal and lateral recess stenosis causing lumbar radiculopathy. Results There were 26 female and 22 male patients. The extradural cysts were most commonly encountered at L4/5 level in 26 patients (72.2%) followed by the L5/S1 level in 8 patients (22.2%), and in 2 patients (5.6%) at the L3/4 level, respectively. One patient underwent T9/10 decompression. At minimum 2-year follow-up, all patients were improved. Excellent results according to the Macnab criteria were obtained in 19/48 (39.6%) patients, good in 18/48 (37.5%), and fair in 11/48 (22.9%), respectively. The average preoperative VAS score for leg pain was 8.06±1.57 and reduced at a statistically significant level (P<0.000) postoperatively to 1.92±1.49, and 1.77±1.32 at final follow-up, respectively. The percentage of patients with unlimited walking endurance had improved at a statistically significant level (P<0.0001) from 33.3% preoperatively (16/48) to 81.3% (39/48) postoperatively. One patient had a recurrent disc herniation, and another patient did not improve. Two patients underwent fusion during the follow-up period. Patients with Fair outcomes had a statistically significant association (P<0.001) with facet instability as suggested by axial T2-weighted magnetic resonance imaging (MRI) findings of thickened ligamentum flavum, facet joint hypertrophy, and bright white fluid-filled joint gap of >2 mm. Conclusions Endoscopic resection of extradural spinal cysts during routine decompression for symptomatic foraminal and lateral recess stenosis is feasible with favorable clinical outcomes in the majority of patients. Fair outcomes were associated with advanced instability of the involved lumbar facet joint complex.
Simulasi Rancangan Antena Planar Bow-tie untuk Aplikasi GPR

Perancangan antena bow-tie mikrostrip dikembangkan guna mendukung pengembangan Teknologi Ground penetrating radar (GPR) pada frekuensi 1,6 GHz. Untuk merancang antena dilakukan dengan menggunakan metode simulasi melalui software microwave office. Material substrat yang digunakan pada simulasi adalah duroid jenis RT/5880, dimana konstanta dielektrik 2,2 dengan ketebalan 1,57 mm. Struktur antena bow-tie terdiri dari dua patch simetris dengan dua saluran pencatu indentik dipasang paralel masing-masing untuk karakteristik impedansi 50 Ohm. Penambahan slot indentik pada masing-masing patch berpengaruh pada performance untuk memperoleh frekuensi resonansi dan bidang grounding sebagian berpengaruh pada lebar bandwidth. Hasil dari simulasi perancangan antena diperoleh parameter, sebagai berikut: bandwidth return loss < 10 dB adalah 285 MHz (wideband), VSWR antara 1 sampai dengan 2 diperoleh 1,025 dengan frekuensi resonansi pada 1,6 GHz, impedansi masukan saat resonansi terhadap karakteristik impedansi 50 Ohm dalam keadaan mismatch. Untuk maksimum directivity radiasi diperoleh 3,39 dB dengan lebar sudut beamwidth adalah 91,2 derajat dan maksimum power radiasi sebesar 5,39 dB pada level diatas 3 dB. Pencapaian target performance sebagai rancangan antena GPR terlihat dengan baik seperti yang terlihat pada bandwidth maupun VSWR terhadap nilai frekuensi kerja yang ditetapkan oleh GSSI ( Geophysical Survey Systems, Inc).
Surgical Correction of Genitourinary Disorders Using the Self-Assembly Tissue Engineering

Urologic and gynaecologic patients often manifest congenital and/or acquired tissue and organ dysfunctions that require surgical reconstruction to recreate the normal genitourinary system functions. Such reconstruction is still a challenge due to the limited availability of suitable tissues, especially for severe urethral and vaginal replacement. Traditional intervention methods have varying degrees of donor site morbidity or inherent side effects. Interestingly, tissue engineering is a growing field that aims to replace or regenerate these dysfunctional tissues and organs with autologous cells, biomaterials, or a combination of both. Experience gained from tissue engineering suggests that the use of acellular matrices alone is not successful in supporting tissue growth over large surfaces. Cellular constituents need to be isolated, cultured and grown in vitro on scaffolds, then transplanted in vivo, in order to achieve successful three-dimensional tissue regeneration. Biomaterials are the backbone for cell-seeded reconstruction of the genitourinary tissues. Several research teams have explored a different cell culture approach based on self-assembly. This innovative technique relies on the capacity of cells cultured in the presence of ascorbate to secrete and deposit their own extracellular matrix forming a tissue-like substance. The mechanical and physical strength properties of these reconstructed tissues are similar to that of natural native tissues in certain models. Tissue engineered substitutes for urethral and vaginal mucosa were produced and subcutaneously grafted with success opening the way to new therapeutic strategies to correct genitourinary defects.
5G microwave vs. millimeter-wave MIMO wireless mobile systems

The next generation of wireless systems, 5G, is intended to cover plenty of new emerging applications such as utra-high resolution multimedia systems, industry 4.0, self-driving vehicles and smart cities. All those different applications require a technology able to deal with three main type of scenarios: enhanced Mobile Broadband (eMBB) systems, Ultra-Reliabe and Low Latency Communications (URLLC) and massive Machine-Type Communications (mMTC). The necessity of achieving high-data rates in wireless systems have led to multi-antenna configurations and MIMO, and massive MIMO
Retrospective Analysis of Microbial Colonization Patterns in Central Venous Catheters, 2013–2017

Objectives This study was performed to provide epidemiological information on microbial colonization in central venous catheters (CVCs). Methods CVCs submitted to Medical Microbiology Laboratory from January 1, 2013, through October 1, 2017, which met our criteria would be included for analysis. Quantitative culture was used for CVCs. The results of culture and related information on CVCs were collected and recorded in detail. The prevalence was calculated, and related factors were analyzed statistically. Results A total of 2020 CVCs were submitted for culture and eligible for analysis. Positive microbial culture occurred in 379 catheters with 18.7% (379 of 2020) prevalence of colonization. There were 23 microbial genera and 45 organisms detected. Among the isolated organisms, there were 39 kinds of isolated bacteria and 6 kinds of isolated fungi. Acinetobacter (19.8%) predominated in total isolated microorganisms, followed by Staphylococcus epidermidis (11.3%) and Candida albicans (10.3%). There were no significant differences in isolated organisms and fungal species between different sexes (X2 = 2.365, P = 0.50). Conversely, there were significant differences in isolated bacterial and fungal species between different wards and years (X2 = 124.046, P = 0.000; X2 = 77.064, P = 0.000). A total of 107 (5.3%, 107/2020) CVCs were associated with a diagnosis of central line-associated bloodstream infection (CLABSI). The most common organisms in causing CLABSI were Acinetobacter (23.4%), S. aureus (13.1%), and Candida albicans (12.1%). Conclusion The prevalence of microbial colonization in CVCs is still significant and even has gradually changed over time. The study provides a new view of microbial colonization pattern in CVCs and a prevalence of CLABSI, which will facilitate catheter-related infection prevention and control in clinic.
Hormonal Contraceptive Uptake and Socio- Demographic Pattern of Acceptors in a Family Planning Clinic of a Tertiary Health Facility in Rivers State, Nigeria

Background: Hormonal methods of birth control are a safe and reliable way to prevent pregnancy for most women. Their uptake rate in comparism to other contraceptive methods in our environment has not been well documented. Objective: To determine the uptake of hormonal contraceptives and assess socio-demographic characteristics related to the choice, among acceptors in a tertiary health facility in Rivers State. Methodology: A hospital-based cross-sectional study was adopted. A sample size of 124 was used. New clients were consecutively recruited over a 12-month period. Demographic data (age, parity, educational level, marital status) and contraceptive-related data (choice of contraceptive method, reasons for use) were obtained and analyzed using SPSS version 20.0. Original Research Article Awoyesuku and Altraide; IJRRGY, 2(1): 1-6, 2019; Article no.IJRRGY. 50322 2 Results: A total of 124 new female clients were recruited with median age of 34 years. Of these, 92(74.2%) accepted hormonal methods while 32 (25.8%) chose non-hormonal methods. Among the hormonal contraceptive acceptors, 94.6% (n=87) used implants, 4.3% (n=4) used injectable and 1.1% (n=1) used oral contraceptive pill. Bivariate analysis of socio-demographic factors and hormonal uptake among the acceptors was statistically significant for marital status, educational level and reason for contraception. Conclusion: We found a substantial uptake of hormonal contraceptives, mainly implants. The uptake was particularly pronounced among married women with higher educational level and whose reason for contraception is completed family size.
The Usability of Electronic Medical Record Systems Implemented in Sub-Saharan Africa: A Literature Review of the Evidence

Background Electronic medical record (EMR) systems hold the exciting promise of accurate, real-time access to patient health care data and great potential to improve the quality of patient care through decision support to clinicians. This review evaluated the usability of EMR systems implemented in sub-Saharan Africa based on a usability evaluation criterion developed by the Healthcare Information and Management Systems Society (HIMSS). Objective This review aimed to evaluate EMR system implementations in sub-Saharan Africa against a well-defined evaluation methodology and assess their usability based on a defined set of metrics. In addition, the review aimed to identify the extent to which usability has been an enabling or hindering factor in the implementation of EMR systems in sub-Saharan Africa. Methods Five key metrics for evaluating EMR system usability were developed based on the methodology proposed by HIMSS. These were efficiency, effectiveness, ease of learning, cognitive load, and user satisfaction. A 5-point rating system was developed for the review. EMR systems in 19 reviewed publications were scored based on this rating system. It awarded 5 points per metric to any EMR system that was identified as excellent, 4 points for good, 3 points for fair, 2 points for poor, and 1 point for bad. In addition, each of the 5 key metrics carried a maximum weighted score of 20. The percentage scores for each metric were then computed from the weighted scores from which the final overall usability score was derived. Results In possibly contributing to the usability of implemented EMR systems, ease of learning obtained the highest percentage score of 71% (SD 1.09) followed by cognitive load in second place with a score of 68% (SD 1.62). Effectiveness followed closely in third place at 67% (SD 1.47) and efficiency was in fourth place at 64% (SD 1.04). User satisfaction came in last at 63% (SD 1.70). The overall usability score for all systems was calculated to be 66%. Conclusions The usability of EMR systems implemented in sub-Saharan Africa has been good with ease of learning possibly being the biggest positive contributor to this rating. Cognitive load and effectiveness have also possibly positively influenced the usability of EMR systems, whereas efficiency and user satisfaction have perhaps contributed least to positively influencing EMR system usability.