Miracle-dz/UniFAR-FTUs huggingface dataset:
Fast delivery of virtual machines and containers : understanding and optimizing the boot operation. (Contributions à l'approvisionnement d'environnements virtualisés : la problématique des temps de démarrage des machines virtuelles et des conteneurs)

The provisioning process of a VirtualMachine (VM) or a container is a succession of three complex stages : (i) scheduling theVM / Container to an appropriate compute node ;(ii) transferring the VM / Container image to that compute node from a repository ; (iii) and finally performing the VM / Container boot process. Depending on the properties of the client’s request and the status of the platform, each of these three phases can impact the total duration of the provisioning operation. While many works focused on optimizing the two first stages, only few works investigated the impact of the boot duration. This comes to us as a surprise as a preliminary study we conducted showed the boot time of a VM / Container can last up to a few minutes in high consolidated scenarios. To understand the major reasons for such overheads, we performed on top of Grid'5000 up to 15k experiments, booting VM / Containerunder different environmental conditions. The results showed that the most influential factor is the I/O operations. To accelerate the boot process, we defend in this thesis, the design of a dedicated mechanism to mitigate the number of generated I/O operations. We demonstrated the relevance of this proposal by discussing a first prototype entitled YOLO (You Only LoadOnce). Thanks to YOLO, the boot duration can be faster 2-13 times for VMs and 2 times for containers. Finally, it is noteworthy to mention that the way YOLO has been designed enables it to be easily applied to other types of virtualization (e.g., Xen) and containerization technologies.
Dodecaphonic Composer Identification Based On Complex Networks

In the musical composition process, even subconsciously, it is common for composers to imprint their personal signature implicitly within the work. This characteristic allows the recognition and the individualization of its origin through the sound assembly. With this in mind, the composer identification through the signature in his works allow us to classify a musical genre into more specific subcategories. However, the characteristics of that signature are of such great variation that make identification task difficult. This paper proposes the use of data mining within complex networks and machine learning techniques to classify a dodecaphonic musical work according to its composer. Considering the dodecaphonic matrix, two types of networks were generated: 1) intervals and 2) series. The feature vector is composed of new melodic topological measures adapted to the calculation from the adjacency matrix and conventional topological measurements. The classifiers Random Forest, AdaBoost and Random Subspace returned high values of accuracy and AUC (> 90%) in the identification of composers Schoenberg, Stravinsky and Webern. Confirming the existence of a relation among the characteristics of the original series, the selection and application of derived series and the composer. The results obtained revealed a good performance and showed that the experiment is very promising.
Efficient state-space exploration for asynchronous distributed programs: Adapting unfolding-based dynamic partial order reduction to MPI programs. (Exploration efficace de l'espace d'état pour les programmes distribués asynchrones: Adaptation de l'UDPOR aux programes MPI)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Efficient state-space exploration for asynchronous distributed programs: Adapting unfolding-based dynamic partial order reduction to MPI programs The Anh Pham
Image Generation Framework for Unbalanced License Plate Data Set

Deep learning based methods have achieved promising performance in the image fields, but they are significantly sensitive to the distribution of data. To obtain balanced data, the acquisition of annotation data is very time-consuming and laborious. Generative Adversarial Networks have made a lot of progress in data generation but may degrade greatly in the unbalanced data set. In this paper, we propose an image generation framework to generate photo-realistic, various, and balanced images of text. Specifically, we add the module for training unpaired images(U-module) and target selector to our framework, and the target selector uses text string to select images in the extended real images, which contain real images and the generated images by the U-module, in addition, global generator and local enhancer network are applied to improve the quality of the generated images. We demonstrate our method on the Chinese license plates, and the unbalance of the license plate data set is shown in the provincial category and the special license plates. The Inception Score and the FID Score are used as metrics to validate our method. The experimental results show that the Inception Score of the generated images is close to that of the real images, and our method achieves the lower FID Score than the state-of-the-art. In the SYSU-ITS dataset, the accuracy of license plate recognition has been largely improved, especially for the provinces with no or few real samples.
The Clinical Curative Effect on Diabetic Peripheral Neurophathy and Nitric Oxide with Pinprick

Objective:To observe and discuss the clinical curative effect and the influence of the vasoactive substances NO of diabetic peripheral neurophathy treated with pinprick.Methods:60 cases of diabetic peripheral neurophathy were randomly divided equally into the treatment group and the control group.All the patients accept diabetes foundation treatment.In the meantime,the control group was treated with methylcobalamin and the treatment group was treated with pinprick.Observe the clinical symptom and change the conduct speed of the motor nerve and sensory nerve before and after two groups with treatment.At the same time the changes of level of Nitric Oxide(NO) were observed.Results:The effective rates of treatment group and the control group were 90% and 60% respectively,the two groups had significant difference(P0.05). The conduct speed of the nerve raised obviously after treatment(P0.01);The NO heated up obviously after treatment(P0.01). Conclusion:It has a good curative effect on the diabetic peripheral neurophathy with pinprick and the level of NO was increased too.
Subgroup Discovery on Multiple Instance Data

Department of Computer Science and Numerical Analysis, University of Cordoba, Cordoba, Spain Andalusian Research Institute on Data Science and Computational Intelligence, University of Jaen, Jaen, Spain Faculty of Computing and Information Technology, King Abdulaziz University, Jeddah, Saudi Arabia Knowledge Discovery and Intelligent Systems in Biomedicine Laboratory, Maimonides Biomedical Research Institute of Cordoba, Cordoba, Spain
Schwann cell reprogramming and lung cancer progression: a meta-analysis of transcriptome data

Schwann cells were identified in the tumor surrounding area prior to initiate the invasion process underlying connective tissue. These cells promote cancer invasion through direct contact, while paracrine signaling and matrix remodeling are not sufficient to proceed. Considering the intertwined structure of signaling, regulatory, and metabolic processes within a cell, we employed a genome-scale biomolecular network. Accordingly, a meta-analysis of Schwann cells associated transcriptomic datasets was performed, and the core information on differentially expressed genes (DEGs) was obtained by statistical analyses. Gene set over-representation analyses was performed on core DEGs to identify significantly functional and pathway enrichment analysis between Schwann cells and, lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). DEGs were further integrated with genome-scale human biomolecular networks. miRNAs were proposed by the reconstruction of a transcriptional and post-transcriptional regulatory network. Moreover, microarray-based transcriptome profiling was performed, and the prognostic power of selected dedifferentiated Schwann cell biomolecules was predicted. We observed that pathways associated with Schwann cells dedifferentiation was overexpressed in lung cancer samples. However, genes associated with Schwann cells migration inhibition system were downregulated. Besides, miRNA targeting those pathways were also deregulated. In this study, we report valuable data for further experimental and clinical analysis, because the proposed biomolecules have significant potential as systems biomarkers for screening or for therapeutic purposes in perineural invasion of lung cancer.
Assessing vulnerability to panic: a systematic review of psychological and physiological responses to biological challenges as prospective predictors of panic attacks and panic disorder

Background Cognitive–behavioural theories of panic disorder posit that panic attacks arise from a positive feedback loop between arousal-related bodily sensations and perceived threat. In a recently developed computational model formalising these theories of panic attacks, it was observed that the response to a simulated perturbation to arousal provided a strong indicator of vulnerability to panic attacks and panic disorder. In this review, we evaluate whether this observation is borne out in the empirical literature that has examined responses to biological challenge (eg, CO2 inhalation) and their relation to subsequent panic attacks and panic disorder. Method We searched PubMed, Web of Science and PsycINFO using keywords denoting provocation agents (eg, sodium lactate) and procedures (eg, infusion) combined with keywords relevant to panic disorder (eg, panic). Articles were eligible if they used response to a biological challenge paradigm to prospectively predict panic attacks or panic disorder. Results We identified four eligible studies. Pooled effect sizes suggest that there is biological challenge response has a moderate prospective association with subsequent panic attacks, but no prospective relationship with panic disorder. Conclusions These findings provide support for the prediction derived from cognitive–behavioural theories and some preliminary evidence that response to a biological challenge may have clinical utility as a marker of vulnerability to panic attacks pending further research and development. Trial registration number 135908.
Human Immunity Against Campylobacter Infection

Campylobacter is a worldwide foodborne pathogen, associated with human gastroenteritis. The efficient translocation of Campylobacter and its ability to secrete toxins into host cells are the 2 key features of Campylobacter pathophysiology which trigger inflammation in intestinal cells and contribute to the development of gastrointestinal symptoms, particularly diarrhoea, in humans. The purpose of conducting this literature review is to summarise the current understanding of: i) the human immune responses involved in the elimination of Campylobacter infection and ii) the resistance potential in Campylobacter against these immune responses. This review has highlighted that the intestinal epithelial cells are the preliminary cells which sense Campylobacter cells by means of their cell-surface and cytosolic receptors, activate various receptors-dependent signalling pathways, and recruit the innate immune cells to the site of inflammation. The innate immune system, adaptive immune system, and networking between these systems play a crucial role in bacterial clearance. Different cellular constituents of Campylobacter, mainly cell membrane lipooligosaccharides, capsule, and toxins, provide protection to Campylobacter against the human immune system mediated killing. This review has also identified gaps in knowledge, which are related to the activation of following during Campylobacter infection: i) cathelicidins, bactericidal permeability-increasing proteins, chemokines, and inflammasomes in intestinal epithelial cells; ii) siglec-7 receptors in dendritic cell; iii) acute phase proteins in serum; and iv) T-cell subsets in lymphoid nodules. This review evaluates the existing literature to improve the understanding of human immunity against Campylobacter infection and identify some of the knowledge gaps for future research.
Crystal structure, Hirshfeld analysis and a molecular docking study of a new inhibitor of the Hepatitis B virus (HBV): ethyl 5-methyl-1,1-dioxo-2-{[5-(pentan-3-yl)-1,2,4-oxadiazol-3-yl]methyl}-2H-1,2,6-thiadiazine-4-carboxylate

The title compound, a new inhibitor of the Hepatitis B virus (HBV), was prepared via alkylation of 3-(chloromethyl)-5-(pentan-3-yl)-1,2,4-oxadiazole in anhydrous dioxane in the presence of triethylamine.
O-016 Development and Validation of an Endovascular Chemotherapy Filter Device for Removing High-Dose Doxorubicin from the Blood: In Vivo Porcine Study

Purpose A novel disposable endovascular chemotherapy filter (CF) device was developed to remove excess doxorubicin (Dox) from the blood during intra-arterial chemotherapy delivery to prevent systemic toxicities. Previous proof-of-concept established the capacity of the filter to bind Dox in swine serum in vitro. In this study, CF navigation, deployment and in vivo Dox binding was evaluated in the porcine inferior vena cava (IVC). Materials and methods An 18 Fr CF device was constructed with an ion-exchange membrane attached to an expandable 28 mm diameter Nitinol frame. Under X-ray fluoroscopy and contrast venography, the CF was percutaneously introduced via the internal jugular vein and deployed in the porcine infrarenal IVC. 50 mg of Dox (2 mg/ml) was injected over 10 min in the IVC below the CF device. Venous catheters with tips proximal and distal to the CF device in the infrarenal IVC obtained pressures and blood samples for Dox concentrations over 90 min across the CF device membrane. Results The CF device was successfully introduced and deployed in the infrarenal IVC in vivo. Visualization under X-ray fluoroscopy verified the proper placement and mechanical expansion of the Nitinol framework. In a 90 min study, the device was biocompatible, not leading to hemodynamic disturbances: pressure measurements taken throughout the experiment yielded a max gradient of 17 mmHg across the CF membrane. Venography demonstrated non-flow-limiting thrombus associated with the CF device after 90 min of deployment (swine were not heparinized). Significant Dox binding was noted with an 85%, 74%, and 83% decrease in relative pre- versus post-filter Dox concentrations at times 3, 10, and 30 min, respectively after Dox injection. Conclusion: We developed a biocompatible CF device that can be safely introduced, deployed, and removed from the IVC in vivo. The CF device demonstrated significant Dox binding, and could serve as a platform technology in drug therapy to allow for higher regional doses of drug while limiting systemic toxicity. In future in vivo experiments, animals or the CF device itself may be heparinized in order to prevent thrombosis. When fully developed, indications for this device could include head and neck cancer, with the device deployed in the superior vena cava or internal jugular veins during selective IA chemotherapy. Disclosures A. Patel: 1; C; NIH-NCI. 4; C; ChemoFilter. A. Chin: 1; C; NIH-NCI. 4; C; ChemoFilter. J. Yang: None. B. Thorne: None. M. Saeed: None. M. Wilson: 1; C; NIH-NIBIB, NIH-NCI. 4; C; ChemoFilter. S. Hetts: 1; C; NIH-NIBIB, NIH-NCI, Siemens, Covidien. 2; C; Stryker, Penumbra, Silk Road Medical, Medina Medical. 4; C; ChemoFilter, Medina Medical, DriftCoast.
Efficacy And Safety Of Controlled-Release Oxycodone For The Management Of Moderate-To-Severe Chronic Non-Cancer Pain In Japanese Patients: Results From An Open-Label Study

Purpose To assess the efficacy and safety of S-8117, an oral, controlled-release formulation of oxycodone hydrochloride, in Japanese patients with chronic non-cancer pain (CNCP). Patients and methods In this multicenter, non-randomized, open-label, 2-part (part 1, dose-titration followed by maintenance period; part 2, long-term administration period) study at 38 centers in Japan (2013–2015), adult patients with CNCP for ≥12 weeks were administered S-8117. The primary endpoint was proportion of patients with successful maintenance of pain control in part 1 and long-term safety in part 2. Secondary endpoints included time to inadequate analgesia, rate of transition to the maintenance period, and discontinuation due to inadequate analgesia/adverse events (AEs), Brief Pain Inventory (BPI) pain severity, BPI pain interference, 36-item Short Form Health Survey (SF-36) score, and Western Ontario and McMaster Universities (WOMAC) index, Subjective Opioid Withdrawal Scale (SOWS), Clinical Opioid Withdrawal Scale (COWS), Dependency-2-A (D-2-A), and Dependency-2-B (D-2-B) questionnaires. Results Of 130 patients (mean age, 63.6 years; women, 62.3%) in the dose-titration period, 95 entered the maintenance period; 60 of 83 who entered the long-term administration period completed it. The proportion of patients (95% confidence interval) with successful maintenance of pain control, transition to maintenance period, and discontinuation due to inadequate analgesia/AEs was 78.9% (69.4–86.6), 73.1% (64.6–80.5), and 21.1% (13.4–30.6), respectively. Time to inadequate analgesia could not be estimated. Changes from baseline in BPI, SF-36, and WOMAC index scores suggested improvements in pain relief and quality of life. Based on the SOWS, COWS, D-2-A and D-2-B questionnaires, no patient developed clinically relevant withdrawal syndrome or was ascertained to have developed drug dependence. Overall, the incidence of treatment-emergent AEs (TEAEs) was 93.8%; most common TEAEs were constipation (49.2%), nausea (42.3%), nasopharyngitis (34.6%), and somnolence (32.3%). Conclusion These results demonstrate the efficacy and safety of S-8117 in Japanese patients with CNCP.
Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD): Current Perspectives

Abstract Despite the availability of global and regional guidelines to curtail the adverse clinical outcomes associated with chronic kidney disease–mineral and bone disorder (CKD-MBD), most CKD patients are still affected by the consequences of abnormalities of CKD-MBD. This important clinical complication of CKD continues to be studied, in order to improve the understanding and management of CKD-MBD. Some notable discoveries include the role of fibroblast growth factor 23 (FGF23) in the pathogenesis of CKD-MBD, leading to a shift from the previous well-established classic trade-off hypothesis to the updated trade-off hypothesis. More recently, there has been a shift from the treatment of CKD-MBD based on a single level of biomarkers to serial measurements of calcium, phosphate and parathyroid hormone (PTH). Furthermore, some clinical trials have emerged after the 2009 Kidney Disease-Improving Global Outcomes (KDIGO) Guidelines, leading to the 2017 KDIGO updated recommendations. Hence, this review gives an overview of the rapidly evolving trends in CKD-MBD, linking the past and current concepts of CKD-MBD.
Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity

Immunosenescence is characterized by a progressive deterioration of the immune system associated with aging. Multiple components of both innate and adaptive immune systems experience aging-related changes, such as alterations in the number of circulating monocytic and dendritic cells, reduced phagocytic activities of neutrophils, limited diversity in B/T cell repertoire, T cell exhaustion or inflation, and chronic production of inflammatory cytokines known as inflammaging. The elderly are less likely to benefit from vaccinations as preventative measures against infectious diseases due to the inability of the immune system to mount a successful defense. Therefore, aging is thought to decrease the efficacy and effectiveness of vaccines, suggesting aging-associated decline in the immunogenicity induced by vaccination. In this review, we discuss aging-associated changes in the innate and adaptive immunity and the impact of immunosenescence on viral infection and immunity. We further explore recent advances in strategies to enhance the immunogenicity of vaccines in the elderly. Better understanding of the molecular mechanisms underlying immunosenescence-related immune dysfunction will provide a crucial insight into the development of effective elderly-targeted vaccines and immunotherapies.
TMEFF2 inhibits pancreatic cancer cells proliferation, migration, and invasion by suppressing phosphorylation of the MAPK signaling pathway

Purpose This paper studied the effect of TMEFF2 expression on pancreatic cancer and its mechanism. Methods A total of 72 pancreatic cancer patients were enrolled. AsPC1 and Panc1 cells were transfected. SB203580 was used to treat AsPC1 cells. CCK8 assay, colony formation analysis, Transwell experiment and Tunel test were performed. In vivo studies in nude mice were conducted. Immunohistochemistry, qRT-PCR and Western blot were used to detect genes expression. Results TMEFF2 was downregulated in pancreatic cancer tissues and cells (P<0.001). Low TMEFF2 expression was associated with larger tumor size and advanced stage and poor differentiation (P<0.01). Compared with the NC group, AsPC1 and Panc1 cells of the TMEFF2 group exhibited much lower OD450 values, colony number, tumor volume and weight, migration and invasion cell numbers, obviously higher E-cadherin protein expression, lower Snail, Vimentin, MMP-2 and MMP-9 proteins expression, lower phosphorylation level of MAPK signaling pathway, and more apoptotic cells. AsPC1 cells of the SB203580 group showed much lower OD450 value when compared with the siTMEFF2 group. Significantly decreased colony number, migration and invasion number, higher E-cadherin protein expression and lower Snail, Vimentin, MMP-2 and MMP-9 proteins expression were found in AsPC1 cells of the siTMEFF2+ SB203580 group when compared with the siTMEFF2+ DMSO group. Conclusion TMEFF2 inhibits pancreatic cancer cells proliferation, migration, and invasion by suppressing the phosphorylation of the MAPK signaling pathway.