Miracle-dz/UniFAR-FTUs huggingface dataset:
Bringing it All Together: Integrating Services to Address Homelessness

Homeless-serving systems are striving for greater impact and efficiency amidst austerity. Those with lived experience, governments, funders, and service providers have consistently and increasingly called for enhanced integration across services, organizations, systems, processes and policies as a means of maximizing existing resources. Here, the discourse of integration refers to ways of working better together across diverse internal and external organizational boundaries. At the heart of these efforts lies the assumption that integration is the desired state, an ideal that will result in improved outcomes at individual and population levels.As actors actively engaged in homeless-serving system planning work, we draw from on-the-ground experiences in Calgary, Alberta to consider how a nuanced understanding of integration can shape the evolution of a systems planning response to homelessness. Our practical experience working in the homeless-serving system on diverse integration initiatives has prompted us to reconsider the evidence and critically probe the implicit link between systems integration efforts and improved individual and population outcomes. In some instances, we have experienced how integration efforts can result in the addition of new layers of complexity to the issue they were created to resolve in the first place. In other cases, integration efforts delivered marginal benefits given the amount of resources used as inputs into planning and implementation. Of course, there are also examples where integration spurs positive impacts at the system and target population levels.Rather than declaring a course of action, this paper is intended to spur discussion. We are posing questions we continue to grapple with at a praxis level, which may resonate with fellow policy makers, system planner organizations, service providers and researchers. We want to go beyond conventional wisdom to probe the merits of integration as a de facto answer to complex social issues by asking:What exactly is integration? When and how is integration appropriate? What are the pitfalls of integration and how do we manage risks? Findings suggest that while ventures to enhance integration remain important, they are not and cannot be the panacea to social challenges, including homelessness. If integration is an appropriate response, we must understand what makes it work, what environment it thrives in, and what success looks like. We maintain that no matter how system integration is implemented or delivered, a central focus on the person served must be maintained, rather than systems themselves.
Décision séquentielle pour la perception active : p-POMDP versus POMDP

Cet article propose une etude du compromis entre la prise d’information et la decision dans un cadre applicatif qui se rapporte a une mission d’exploration, ou l’agent interagit avec son environnement pour identifier l’etat cache du systeme. Dans ce probleme de decision sequentielle pour la perception, il est possible de faire reposer la fonction de recompense sur une mesure de l’incertitude sur l’etat de croyance de l’agent (Araya-Lopez et al., 2010; Candido & Hutchinson, 2011; Eidenberger & Scharinger, 2010). Sa forme est donc differente de celle utilisee dans le cadre classique des POMDP qui est, pour sa part, basee sur la paire etat-action. Nous comparons donc deux approches d’optimisation des politiques pour ce type de probleme. D’une part nous proposons un critere mixte qui couple une mesure de l’incertitude sur l’etat de croyance avec les recompenses definies par les paires etat-action et nous developpons un schema algorithmique de resolution pour ce critere. D’autre part, nous proposons d’ajouter au modele des etats but fictifs au moyen des actions de classification afin de revenir a une modelisation sous-forme de POMDP classique (critere non mixte). Une etude comparative de ces approches est ici presentee afin de verifier leur equivalence en termes de prise d’informations. Les resultats nous menent a conclure que ces approches sont non seulement comparables et equivalentes en termes de reduction d’incertitude, mais aussi, qu’elles peuvent etre utilisees en parfaite complementarite de facon a permettre : de caracteriser une politique correspondant aux taux acceptables des bonnes et mauvaises classifications et de determiner les bonnes valeurs des couts et des recompenses du modele POMDP classique.
Integrated process for high conversion and high yield protein PEGylation

Over the past decades, PEGylation has become a powerful technique to increase the in vivo circulation half‐life of therapeutic proteins while maintaining their activity. The development of new therapeutic proteins is likely to require further improvement of the PEGylation methods to reach even better selectivity and yield for reduced costs. The intensification of the PEGylation process was investigated through the integration of a chromatographic step in order to increase yield and conversion for the production of mono‐PEGylated protein. Lysozyme was used as a model protein to demonstrate the feasibility of such approach. In the integrated reaction/separation process, chromatography was used as fractionation technique in order to isolate and recycle the unreacted protein from the PEGylated products. This allows operating the reactor with short reaction times so as to minimize the production of multi‐PEGylated proteins (i.e., conjugated to more than one polymer). That is, the reaction is stopped before the desired product (i.e., the mono‐PEGylated protein) can further react, thus leading to limited conversion but high yield. The recycling of the unreacted protein was then considered to drive the protein overall conversion to completion. This approach has great potential to improve processes whose yield is limited by the further reaction of the product leading to undesirable by‐products. Biotechnol. Bioeng. 2016;113: 1711–1718. © 2016 Wiley Periodicals, Inc.
Reconstitution of Caspase-3 Confers Low Glucose-Enhanced Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Cytotoxicity and Akt Cleavage

Purpose and Experimental Design: We have previously observed that glucose deprivation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptotic death as well as caspase activation (caspase-3, -9, and -8) in human prostate adenocarcinoma DU-145 cells. In this study, we used caspase-3-deficient MCF-7 breast cancer cells to examine the possible role of caspase-3 in glucose deprivation-enhanced TRAIL cytotoxicity. Results: Combined glucose deprivation and 200 ng/ml TRAIL treatment markedly induced cytotoxicity in caspase-3 cDNA transfected cells (MCF-7/casp-3) but not in control vector transfected cells (MCF-7/vector). We also observed that the level of Akt, an antiapoptotic protein, was reduced by treatment with TRAIL in MCF-7/casp-3 cells but not in MCF-7/vector cells. The reduction of Akt by TRAIL was promoted in the absence of glucose in MCF-7/casp-3 cells. However, pretreatment with 20 μm Z-LEHD-FMK, a caspase-9 inhibitor, protected MCF-7/casp-3 cells from the combinatorial treatment of TRAIL and glucose deprivation-induced cytotoxicity. This compound also prevented the reduction of Akt level during the combinatorial treatment. Moreover, this Akt reduction was not inhibited by treatment with MG-132, a proteosome inhibitor. Data from site-directed mutagenesis show that Akt was cleaved at amino acid 108, but not 119, during treatment with TRAIL and glucose deprivation. Conclusions: Our results suggest that caspase-3 is involved in the reduction of Akt level, and its involvement is mediated through caspase-9 activation. The reduction of Akt level is also due to cleavage of Akt rather than degradation of Akt.
Deep Contextual Embeddings for Address Classification in E-commerce

E-commerce customers in developing nations like India tend to follow no fixed format while entering shipping addresses. Parsing such addresses is challenging because of a lack of inherent structure or hierarchy. It is imperative to understand the language of addresses, so that shipments can be routed without delays. In this paper, we propose a novel approach towards understanding customer addresses by deriving motivation from recent advances in Natural Language Processing (NLP). We also formulate different pre-processing steps for addresses using a combination of edit distance and phonetic algorithms. Then we approach the task of creating vector representations for addresses using Word2Vec with TF-IDF, Bi-LSTM and BERT based approaches. We compare these approaches with respect to sub-region classification task for North and South Indian cities. Through experiments, we demonstrate the effectiveness of generalized RoBERTa model, pre-trained over a large address corpus for language modelling task. Our proposed RoBERTa model achieves a classification accuracy of around 90% with minimal text preprocessing for sub-region classification task outperforming all other approaches. Once pre-trained, the RoBERTa model can be fine-tuned for various downstream tasks in supply chain like pincode suggestion and geo-coding. The model generalizes well for such tasks even with limited labelled data. To the best of our knowledge, this is the first of its kind research proposing a novel approach of understanding customer addresses in e-commerce domain by pre-training language models and fine-tuning them for different purposes.
Emotive computing may have a role in telecare

This brief paper sets out arguments for the introduction of new technologies into telecare and lifestyle monitoring that can detect and monitor the emotive state of patients. The significantly increased use of computers by older people will enable the elements of emotive computing to be integrated with features such as keyboards and webcams, to provide additional information on emotional state. When this is combined with other data, there will be significant opportunities for system enhancement and the identification of changes in user status, and hence of need. The ubiquity of home computing makes the keyboard a very attractive, economic and non-intrusive means of data collection and analysis.
Lysosomal enzymes in human platelets

In human freshly prepared platelets the following lysosomal enzymes were studied: α‐mannosidase, α‐fucosidase, β‐galactosidase, β‐glucosidase, β‐glucuronidase, β‐N‐acetylglucosaminidase and acid phosphatase. For each of the examined enzymes the conditions providing maximal activity (pH, buffer), kinetic parameters (saturating substrate concentration and Km) as well as heat stability were established. On the basis of these parameters it is suggested that many of the serum glycohydrolases may be platelet derived.
A New Parallel Hybrid Excitation Machine: Permanent-Magnet/Variable-Reluctance Machine With Bidirectional Field-Regulating Capability

This paper presents a new topology of parallel hybrid excitation machine (PHEM), which integrates permanent-magnet synchronous motor (PMSM) and variable-reluctance machine, namely, doubly salient electromagnetic machine (DSEM), and provides a solution to better field-regulating capability. The configuration and the operation principle of the proposed PHEM are introduced. The combination criterion and design consideration are discussed. The performances of the two axial sections (PMSM and DSEM) are studied by 2-D finite-element analysis (FEA), respectively, to achieve reasonable integration. The field and voltage regulation capability of the PHEM is further investigated by 3-D FEA. A prototype PHEM is designed, manufactured, and tested. The measured results verify structural validity and finite-element predictions. The loss is predicted, and the measurement of short-circuit current illustrates the capacity of deexcitation at fault. The results confirm that the PHEM achieves effective power superposition of two different brushless machines. Bidirectional field-regulating capability facilitates a wide field regulating range of 6.5:1 under no load.
Influence of branching characteristics on thermal and mechanical properties of Ziegler–Natta and metallocene hexene linear low-density polyethylene blends with low-density polyethylene

The effect of the branch content (BC) and composition distribution (CD) of linear low-density polyeth- ylene (LLDPE) on the thermal and mechanical properties of its blends with LDPE were studied. All blends and pure resins were conditioned in a Haake PolyDrive blender at 190°C and in the presence of adequate amounts of antioxi- dant. Two metallocene LLDPEs (m-LLDPE) and one Ziegler-Natta (ZN) hexene LLDPE were melt blended with the same LDPE. The effect of the BC was investigated by blending two hexene m-LLDPEs of similar weight-average molecular weights and molecular weight distributions but different BCs with the same LDPE. The effect of the CD was studied by using a ZN and an m-LLDPE with similar weight-average molecular weights, BCs, and comonomer type. Low-BC m-LLDPE blends showed separate crystalli- zation whereas cocrystallization was observed in the high- BC m-LLDPE-rich blends. However, ZN-LLDPE/LDPE blends showed separate crystallization together with a third population of cocrystals. The influence of the crystallization behavior was reflected in the mechanical properties. The BC influenced the modulus, ultimate tensile strength, and toughness. The addition of a small amount of LDPE to a low-BC m-LLDPE resulted in a major improvement in the toughness, whereas the results for the high-BC pair followed the additivity rule. ZN-LLDPE blends with LDPE blends were found to be more compatible and exhibited superior mechanical properties compared to m-LLDPE counterparts with the same weight-average molecular weight and BC. All mechanical properties of ZN-LLDPE blends follow the lin- ear rule of mixtures. However, the CD had a stronger influ- ence on the mechanical properties in comparison to the BC. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 97: 2488 -2498, 2005
Effect of entrepreneurs’ risk preference on organization efficacy of small and medium enterprises in Kenya

Small and medium enterprises (SMEs) are generally thought to play a crucial role in driving economic growth in both developing and developed countries however, entrepreneurial behavior such as entrepreneur’s judgment and capabilities to perform a given actions such as risk assessment is an important means of growth to small and medium enterprises but no study has attempted to cover it. Thus, this study focused on determining the effect of entrepreneurs’ risk preference on organization efficacy of small and medium enterprises in Kenya. The study utilized the explanatory research design and a survey of small and medium enterprises in western Kenya namely, Kisumu, Nakuru and Eldoret town in Kenya. A sample size of 267 respondents is derived from a target Population of 900 enterprises. Structured questionnaire and systematic random sampling technique were used. Descriptive statistics, Pearson correlation analysis, factor analysis and multiple regressions were used to analyze data. The study findings showed that entrepreneurs’ risk preference positively and significantly affect organization efficacy. Similarly, entrepreneurs’ risk preference is an important factor of organization efficacy. It was concluded that entrepreneurs’ risk preference is important in determining efficacy in management of small firms. Recommendations are made based on managerial implications useful for business practitioners and trainers.
Amyloid Assemblies: Protein Legos at a Crossroads in Bottom‐Up Synthetic Biology

One of the major objectives that bottom‐up synthetic biology shares with chemical biology is to engineer extant biological molecules to implement novel functionalities in living systems. Proteins, due to their astonishing structural and functional versatility and to their central roles in the biology of cells, should be cornerstones of synthetic biology. In particular, protein amyloid cross‐β assemblies constitute one of the most stable, conceptually simple and universal macromolecular architectures ever found in Nature and thus have enormous potential to be explored. This article focuses on the concepts behind the use of the amyloid cross‐β‐structural framework as a synthetic biology part, underlining recent basic findings and ideas. The pros and the cons associated with the polymorphism and the cellular toxicity of protein amyloids are also discussed, keeping in mind the possible suitability of these protein assemblies for scaffolding novel orthogonal macromolecular devices in vivo.
Group communication system based on MAC-over-IP

We have researched a regional personal computer (PC) communication network system to provide group communication services to regional community members cost-effectively. Its LAN-like environment enables pre-registered users to communicate with each other using a PC at any time. An STM-based system, which transfers Ethernet frames to/from users' PCs using HDLC (high-level data link control) protocol over ISDN access lines, has already been developed. Access systems that directly provide an Ethernet interface to users such as shared STM-PDS (synchronous transfer mode passive double star) and cable modem systems have recently been introduced. The communication services provided with the current access systems are basically Internet protocol (IP) services. Such access systems will be required to support protocol-free communication services as well as group communication services. We propose a new system architecture that is applicable to many kinds of access systems including shared STM-PDS and cable modem systems. It is based on MAC-over-IP where Ethernet frames from users' PC are encapsulated into IP packets in the edge device and filtered using the PC MAC (media access control) addresses in the center node. This paper describes the system architecture and its operations. The system can provide protocol-free services and guaranteed security to users. The processing load of the center node is reduced by cutting through the decapsulation of MAC-over-IP packets by controlling the ARP (address resolution protocol) packets. Performance evaluation results for a prototype system are presented.
A cognitive–perceptual model of symptom perception in males and females: The roles of negative affect, selective attention, health anxiety and psychological job demands

Kolk et al.’s model of symptom perception underlines the effects of trait negative affect, selective attention and external stressors. The current study tested this model in 263 males and 498 females from an occupational sample. Trait negative affect was associated with symptom reporting in females only, and selective attention and psychological job demands were associated with symptom reporting in both genders. Health anxiety was associated with symptom reporting in males only. Future studies might consider the inclusion of selective attention, which was more strongly associated with symptom reporting than negative affect. Psychological job demands appear to influence symptom reporting in both males and females.
On effectively discontinuous type-2 objects

The notion of a recursive function with type-2 arguments was introduced by Kleene [4]. Soon E, the type-2 object that introduces numerical quantification, began to play a central role in the development of the theory. First, Kleene [4, XLVIII] proved that the hyperarithmetical functions are exactly the functions recursive in E. Later, Gandy [1, p. 14] proved the existence of a selection operator recursive in E (that is, some ψ(х, ), partial recursive in E, having the property that, if {х}(y, ) converges for some y, then ψ(х, ) converges and is such a y).
Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1.

Pokeweed antiviral protein (PAP) is a naturally occurring broad-spectrum antiviral agent with potent anti-human immunodeficiency virus (HIV)-1 activity by an as yet undeciphered molecular mechanism. In the present study, we sought to determine if PAP is capable of recognizing and depurinating viral RNA. Depurination of viral RNA was monitored by directly measuring the amount of the adenine base released from the viral RNA species using quantitative high-performance liquid chromatography. Our findings presented herein provide direct evidence that three different PAP isoforms from Phytolacca americana (PAP-I from spring leaves, PAP-II from early summer leaves, and PAP-III from late summer leaves) cause concentration-dependent depurination of genomic RNA (63 to 400 pmols of adenine released per micrograms of RNA) purified from human immunodeficiency virus type-I (HIV-I), plant virus (tobacco mosaic virus (TMV), and bacteriophage (MS 2). In contrast to the three PAP isoforms, ricin A chain (RTA) failed to cause detectable depurination of viral RNA even at 5 microM, although it was as effective as PAP in inhibiting protein synthesis in cell-free translation assays. PAP-I, PAP-II, and PAP-III (but not RTA) inhibited the replication of HIV-1 in human peripheral blood mononuclear cells with IC(50) values of 17 nM, 25 nM, and 16 nM, respectively. These findings indicate that the highly conserved active site residues responsible for the depurination of rRNA by PAP or RTA are not sufficient for the recognition and depurination of viral RNA. Our study prompts the hypothesis that the potent antiviral activity of PAP may in part be due to its unique ability to extensively depurinate viral RNA, including HIV-1 RNA.
The complete mitochondrial genome of Culter dabryi (Cyprinidae: Cultrinae)

Abstract Culter dabryi, a medium-sized economic cyprinid fish, is widely distributed in East Asia. We sequenced the complete mitochondrial genome of this species. The genome is 16,622 bp in length, and consists of 22 transfer RNA genes, 13 protein-coding genes, two ribosomal RNA genes and the non-coding control region with a structural organization conserved relative to that of other fishes. The overall base composition of C. dabryi in descending order is A 31.51%, C 27.60%, T 24.95% and G 15.94%, with a slight A + T bias. The mitogenome sequence data may provide useful information to the population genetics analysis of C. dabryi and the elucidation of evolutionary mechanisms in the endemic clade of East Asian Cyprinidae.
Effects of Various Dietary Arginine and Lysine Concentrations on Plasma and Liver Cholesterol Concentrations in Rats

Background: It has been hypothesized that the arginine:lysine ratio of dietary proteins influences cholesterol concentrations in plasma and liver of men and animals. This study was performed to test this hypothesis in rats by using diets with various concentrations of arginine and lysine, differing in their arginine:lysine ratios. Methods: Two experiments with growing rats were performed, some of which received diets containing 4.5, 9 or 18 g arginine/kg and 9 or 18 g lysine/kg, respectively, for a period of 21 days. In the first experiment, a cholesterol-free diet was used; in the second experiment, a diet supplemented with cholesterol and sodium cholate as hypercholesterolaemic compounds was used. Results: In experiment 1, increasing the arginine concentration lowered HDL and plasma cholesterol concentration; however, cholesterol concentrations in liver, LDL and VLDL remained unchanged. In experiment 2, increasing the arginine concentration lowered HDL cholesterol and increased liver cholesterol (p < 0.05); cholesterol concentrations in plasma, LDL and VLDL remained unchanged. The only effect of the dietary lysine concentration concerned the effect on VLDL and liver cholesterol concentration, which were both lower in rats fed the diets with 18 g lysine/kg than in those fed the diets with 9 g lysine/kg (p < 0.05). Varying the dietary arginine:lysine ratio between 0.25 and 2.0 had no influence on cholesterol concentration in LDL and VLDL in both experiments; HDL cholesterol concentration was lowered by increasing this ratio (p < 0.05). Conclusion: The present study does not support the hypothesis that an increase in the dietary arginine:lysine ratio causes hypocholesterolaemic effects in rats.