Miracle-dz/UniFAR-FTUs huggingface dataset:
Impelementation of Information Technology Service Management at Data And Information System Center of XYZ University

Information Technology (IT) is increasingly progressing. Nowadays, the success of a business of the organization/company is highly dependent on the IT infrastructure used. Therefore, organizations/companies have to manage their IT service to be optimal to their customers. Looking at this matter and the increasing dynamics of XYZ University, then Data and Information System Center (Pusdatin) - an IT provider of XYZ University began implementing IT Service Management (ITSM) from 2013 using the latest version of Information Technology Infrastructure Library (ITIL), namely ITIL v3 as a framework for implementing ITSM in its business processes. However, along the way, there are still some problems happen in Pusdatin in order that ITSM can actually support and align with the objectives of XYZ University. Through this paper, the authors want to explain how the implementation of ITSM at Pusdatin, identify the problems related to the implementation of ITSM, and provide the solutions for each problem. The methods used are direct observation to Pusdatin, conductan interview with the Head of Pusdatin and Staff of Pusdatin, and also perform a literature review of books and papers that discuss about ITIL. The result of this research is that ITSM process of Pusdatin generally works quite well but there are still some shortcomings because ITSM is not 100% implemented in all areas.
Anxiety and Depression: Can Diet Help?

In November 1944, Dr. Ancel Keys and Dr. Josef Brozek, faculty at the University of Minnesota, conducted a study on the effects of starvation, known as the Minnesota Starvation Study (Baker & Keramidas, 2013). Through this study, it was observed that a lack of nutrients can lead to intense physical and psychological changes such as decreased strength and stamina, as well as increased fatigue, irritability, depression, and overall disinterest (Baker & Keramidas, 2013). This was the first study of its kind to demonstrate the connection between nutrition and mental health.
Postpartum Depression in Women with Normal Delivery and Cesarean Section Referring to Sayad Shirazi Hospital of Gorgan , Iran

Background and objectives : During the postpartum period, mothers may experience physical and emotional changes. Postpartum Depression (PPD) may affect 10-15% of all women after delivery. In some studies, the type of delivery has been considered as a risk factor for postpartum depression. The present study was designed to investigate and compare the frequency of postpartum depression in women with normal and cesarean delivery. Methods: This descriptive-analytic study was conducted on 300 women referring to the Sayad Shirazi Hospital. First the Women who had Beck depression inventory score>12 were excluded and then the participants were divided into two equal groups of normal (150) and cesarean (150) delivery. Two weeks after delivery, Beck depression inventory was filled out and data analysis was performed by SPSS software V.16 using, chi-square and Mann-Whitney test. Results: Results showed that 13% of all participants 12.7% of the cases in normal and 13.3% in cesarean groups had postpartum depression. The severity of depression was higher in women with cesarean delivery compared to normal delivery and this difference was significant (mean rank 172.29 vs. 128.71, p<0.0001). There was no significant difference in the level of depression between two groups according to their age, job, parity, baby’s sex, marital satisfaction and wanted/unwanted pregnancy. Conclusion: The prevalence of postpartum depression was higher in women with caesarian delivery compared to women with normal delivery
Advances in Molecular Mechanisms and Immunotherapy Involving the Immune Cell-Promoted Epithelial-to-Mesenchymal Transition in Lung Cancer

Immunotherapy has offered a new opportunity for the treatment of many malignancies. In patients with lung cancer, immune checkpoint inhibitors have significantly improved survival. However, little is known about predictive factors or primary and acquired resistance mechanisms. Epithelial-to-mesenchymal transition (EMT) is a complex of phenotypic changes involved in carcinogenesis and resistance to cancer treatments. Specifically, immune cells in the tumor microenvironment can promote EMT, and mesenchymal phenotype acquisition negatively regulates the anticancer immune response. EMT is associated with higher expression of PD-L1 and other immune checkpoints. In this review, we focused on the role of EMT in the interplay between tumor cells and the immune system, with particular emphasis on lung cancer. On the basis of our findings, we hypothesize that the effects of EMT on immune cells could be overcome in this disease by a new combination of immune checkpoint inhibitors.
A novel approach for extracting ideal exemplars by clustering for massivetime-ordered datasets

The number and length of massive datasets have increased day by day and this yields more complex machine learning stages due to the high computational costs. To decrease the computational cost many methods were proposed in the literature such as data condensing, feature selection, and filtering. Although clustering methods are generally employed to divide samples into groups, another way of data condensing is by determining ideal exemplars (or prototypes), which can be used instead of the whole dataset. In this study, first the efficiency of traditional data condensing by clustering approach was confirmed according to obtained accuracies and condensing ratios in 9 different synthetic or real batch datasets. This approach was then improved to be employed in time-ordered datasets. In order to validate the proposed approach, 23 different real time-ordered datasets were used in experiments. Achieved mean RMSEs were 0.27 and 0.29 by employing the condensed (mean condensed ratio was 97.17%) and the whole datasets, respectively. Obtained results showed that higher accuracy rates and condensing ratios were achieved by the proposed approach.
Effect of garlic (allium sativum l.) in fattening chicks nutrition

The paper examines the effects of garlic (Allium sativum L.) and Cu separately as well as their combined effects on the production parameters and carcass quality in broiler chicks. Garlic has antimicrobial, antihypertensive and antioxidative properties, while high copper levels in feed (100 ppm) displays stimulating and bacterial effects, which may be an alternative to antibiotics whose use is prohibited by the EU. Bearing in mind the aforementioned, the objective of this study was to prove the effects of garlic in broiler feed on production parameters, health status and carcass quality. The testing was carried out under production conditions with one-day-old Hubbard broilers of the same weight divided in 4 groups, each consisting of 75 birds, in 4 repetitions. Treatment groups were given: 2% of commercial garlic in group II, 2% garlic and 100 ppm Cu in group III, and 100 ppm Cu in group IV. At the end of the experiment which lasted 42 days it was found that the addition of garlic led to a significant (P < 0.05) increase of body mass in group II (2055.55 g) and group III (2038.65 g) in comparison to the control group (1964.52 g). The feed exploitation was found to be better in groups treated with garlic. Key words: Garlic, copper, broilers, production parameters, carcass quality.
Radiologic clues to differentiate metastases from other brain pathologies with histopathological correlation

Introduction: The dissemination of tumour cells to the brain parenchyma does solely occur via the blood stream, as the brain lacks lymphatic vessels. Therefore, tumour cells have to manage survival and adapt to the changed microenvironment within the bloodstream. Several preclinical studies indicate that tumour cells might aggregate with platelets and leucocytes in order to survive. Methodology: This study was performed at the Department of Radio-diagnosis, and the patients selected for the study were referred from Neurosurgery/Neurology OPD or Emergency department at our hospital, who were clinically suspected to have a space occupying lesion or having history suggestive of metastases. The patients presented with symptoms like headache, motor weakness, diminished vision, double vision, seizure. All patients were seen by appointment, except for the emergency cases. Relevant history of illness and significant clinical findings of all patients were recorded. Results: Out of 50 cases adenocarcinoma (66%) was the most common histopathology metastasized to the brain followed by squamous cell type (16%), Melanoma (6%), GBM (2%), Oligodendroglioma (2%), liposarcoma (2%) and choriocarcinoma (2%). Conclusion: In our study most common primary site of metastases was from lung (60%), site of origin of primary was not identified in the 10% cases, third common primary was from breast (6%), kidney (6%), Melanoma(6%) followed by brain (2%), thyroid(2%), Cervix (1%) and uterus(1%).
Differences between Male and Female College Students in Dynamic Stability Change through Measuring Lower Extremity Muscle Fatigue

OBJECTIVES The purpose of this study was to compare and analyze differences by gender, changes in dynamic stability due to lower extremity muscle fatigue. METHODS A total of 47 college-age students participated in the experiment. Subjects consisted of 29 males and 19 females. A muscle fatigue squat protocol with Smith machine and Y-balance Test was conducted and measurements were taken before and after the onset of fatigue. RESULTS There were statistically significant differences before and after fatigue in anterior right leg (p<.001), anterior left leg (p<.001), posteromedial right leg (p=.011), posteromedial left leg (p=.010), pesterolateral left leg (p=.014), total score right leg (p<.001) and total score left leg (p<.001), the only exception being posterolateral right leg (p=.057). The difference between male and female groups decreased in a statistically significant manner on posteromedial left leg (p=.045) and posterolateral right leg (p=.031). The effects of interaction between measurement periods did not represent statistically significant differences in all categories. CONCLUSIONS The result of this study represented a decrease in total score of Y-balance Test before and after the application of muscle fatigue. There were no gender differences in the dynamic stability of male and female subjects due to muscle fatigue.
Coping with stress and hypertension-mediated organ damage

Material and methods: Each study participant (n=93) underwent the following procedures: clinical assessment, echocardiography, pulse wave velocity measurement and psychological testing. Blood pressure in the study group was measured using ABPM method. Carotid-femoral pulse wave velocity (PWV) was assessed to identify patients with arterial stiffness. Left ventricular mass index was measured to diagnose LVH. Each patient was also assessed using three psychometric tools: PSS-10, CISS and Brief COPE.
Разделение речи целевого и сторонних дикторов с использованием двухмикрофонной системы

The study reviews foreign and Ukrainian theory and practice in terms of business infrastructure. The infrastructure is one of the key factors to success of small and medium-sized ISSN 2223-3822 © Socio-Economic Problems and the State, Vol. 8, No. 1, 2013 ‹ 8 › enterprises which ensures their efficient operation. This paper defines small business infrastructure as a set of state and public institutions (organizations, entities) which provide support services to enterprises, facilitate their economic activity and enhance its efficiency. The article concludes that organizational and informational infrastructure of small business support should be identified as an array of business support services (informational, consulting and legal) offered by authorized institutions to facilitate small businesses. This study takes a look at the system of small business infrastructure in the country, its state, development and government support. Currently business incubators in the form of technology parks are the type of business assistance programs which prevail in regions and help startup and early-stage companies with technical advice during their first, the most difficult, year in the marketplace. Business incubators are nonprofit organizations financed by communities or sponsors. They can only recover 10 – 60 % of their cost. That is why the government, that declares state support to small business, should share the cost of business incubator programs and encourage sponsors and venture capitalists to give financial support. The dissertation studies the mechanisms of business incubator operation and the stages of its development. It analyzes the development of small business infrastructure elements in Ukrainian over the past 10 years. The analysis of regional business support programs implementation shows that no more than 5.2% of local budgets are allocated to develop the infrastructure. As a result, the majority of regions do not have an established network of financial credit or advisory infrastructure of business assistance, or it develops spontaneously, uncoordinated by local authorities which reduces the efficiency of infrastructure as a driving force of local small business development. The research uncovers the problems and offers ways to improve the infrastructure development.
On information filtering in social sensing

For decades, from the invention of Sensor Networks, people envisioned a global sensing platform with millions of sensors deployed globally. The platform has finally become real recently with the advent of multiple online social network services where humans act as sensors and the social networks act as sensor networks, a practice named Social Sensing. Social sensing was born with the advances of high-level semantics sensing (since humans are the “sensors” with texts or photos as the sensing data) and (almost) zero-cost real-time data infrastructure, which makes this new sensing paradigm very promising in multiple real-world applications including disaster response and global event discovery. However, its global scale results in a massive amount of data generated and collected in applications that far exceeds normal people’s cognitive capability of information consumption, thus we desire a system that can filter the massive sensing data and delivers only information and intelligence to the users with a human-consumable amount. In this thesis, I focus on designing an information filtering system for social sensing; specifically, I focus on three levels of information filtering. In the first level, we focus on untruthful information removal, also known as fact-finding, where the challenge lies in the unknown reliability of each individual social sensor (i.e. human) a prior. In the second level, we focus on event-level information summary, also known as event detection, where the challenge lies in de-multiplexing different event instances and fusing social events detected in multiple social networks that previous approaches do not perform well. In the third level, we focus on information-maximizing data delivery to social sensing users, especially on redundancy removal by diversifying the information feed, where the challenge lies in algorithm design that not only works well empirically but also has a theoretical performance guarantee. We address the above challenges by algorithm design and system implementation and real-world data evaluations verify the efficiency of our proposed solutions.
Disentangling the relationship between white matter disease, vascular risk, Alzheimer's disease pathology and brain atrophy: timing of events and location of changes

This thesis is an investigation into vascular risk, vascular brain lesions, and age contributions to brain atrophy and cognitive decline in Alzheimer’s disease (AD). Associations of white matter hyperintensities (WMHs) to longitudinal hippocampal atrophy were explored in control, mild cognitive impairment (MCI) and AD participants enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI1). Also using ADNI1 data, I identified differences in longitudinal brain atrophy patterns in younger vs. older AD patients. Blood pressure (BP), cognition and brain atrophy were jointly modelled to see how changes in each variable are correlated in ADNI1 and National Alzheimer’s Coordinating Centre (NACC) participants. The independent associations of microbleeds (MBs), lacunes and WMHs to longitudinal atrophy were also explored in ADNIGo and ADNI2. Lastly, I developed a new protocol for semi-automated WMH segmentation and generated ‘gold standard’ segmentations with which to assess the performance of an automated WMH segmentation algorithm. WMHs were found to associate with hippocampal atrophy in controls and MCI, which survived correction for CSF biomarkers of amyloid and tau, and concurrent brain atrophy. Secondly, I found that younger AD patients have greater extra- hippocampal atrophy, with a prominent posterior atrophy pattern, and faster atrophy rates compared to older AD patients. Greater hippocampal atrophy rates were found in MCI and AD patients with higher baseline systolic BP. In ADNI2 and ADNIGo subjects MB presence and WMH volume were associated with increased longitudinal brain atrophy rate, whilst presence of a lacune was associated with a reduced atrophy rate. Lastly, I showed that the automated WMH segmentation algorithm compares well to the ‘gold standard’, and automated volumes were able to predict cognitive change across disease types. This work extends existing knowledge about how age, vascular risk and brain lesions with a presumed vascular aetiology, link with brain atrophy and cognitive decline in ageing and AD.
Abstract 4452: GNE-0011, a novel monovalent BRD4 degrader

The bromodomain and extra-terminal (BET) family of proteins (BRD2, 3, 4 and T) has been the focus of an emerging paradigm in drug mechanism of action, whereby a drug is designed to trigger the proteolytic degradation of the target protein. The current design of protein degraders is typically based on bivalent molecules consisting of a ligand for the target protein and a ligand for a ubiquitin ligase (such as VHL, CRBN or XIAP). The degrader causes the association of the target protein with the E3 ubiquitin ligase and its subsequent ubiquitination and degradation. Due to their bivalent design such drugs typically have a higher molecular weight than classic small molecule drugs and may present some non-ideal properties as drugs. An alternative strategy for designing drugs that act through the degradation of the target protein is exemplified by the group of drugs termed SERDs (selective estrogen receptor degraders), for example fulvestrant. The molecular structures of SERDs are typically designed around an estrogen receptor ligand and a “degradation tail”, whose presence results in the degradation of the estrogen receptor. We will discuss the development of GNE-0011, which represents a novel class of monovalent BRD4 degrader that uses a “degradation tail” strategy. Citation Format: Robert A. Blake. GNE-0011, a novel monovalent BRD4 degrader [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4452.
Impact of demographic, clinical and psychological variables of patients and caregivers on the perception of burden among the family caregivers of patients with cancer

The study aims were to assess the level of burden among caregivers of patients diagnosed with cancer and to examine patient and caregiver variables associated with high levels of burden. A descriptive cross sectional study was performed at the Psychiatric Department in the University Hospital of Monastir, Tunisia. The study included a total of 138 dyads of patients and their corresponding family caregivers. The dyads were convoked then examined. The data were assembled using questionnaires elaborated by the research team and caregiver burden was measured with the Zarit Burden Interview. Patients completed the Hospital Anxiety and Depression Scale and the KATZ Index of Activities of Daily Living. About one third of the caregivers experienced high levels of burden. The scores at the Zarit Burden Interview ranged from 15 to 70 and mean score was 48.7 (SD =18.2). This negative outcome of caregiving was found to be related to both patients’ and caregivers’ variables. Statistically, the factors associated to high levels of burden among family caregivers that are linked to the patient’s profile were: male gender, age between 61 and 70 years old, having other medical morbidities, necessitating pre and post-operative chemotherapy, having intermediate to high levels of anxious or depressive symptoms and a severe functional impairment. Caregivers who helped their patients to accomplish many daily activities were found to be high-burdened. The caregiver variables that were found to be related to high levels of burden among caregivers were: male gender, age between 40 and 59 years old, employed full-time status, being the child of the patient, having another member of the family needing daily care, caregiving period more than one year, and not resorting to a professional healthcare at home. The current study demonstrates the importance of a systematic assessment and early intervention procedures needed in order to detect vulnerable caregivers.
Rehabilitation of hearing by cochlear implantation

A cochlear implant (CI) is a surgically implanted electronic device that transmits sounds directly to the auditory nerve through electrical stimulation of the cochlea. It has become the standard of care for severe or profound losses in hearing and indeed has produced the irst substantial restoration of a lost or absent human sense using a medical intervention. It has proven to be a useful treatment option for individuals with severe-to-profound hearing loss by providing improved access to one’s surrounding auditory environment. Both postlingually deafened adults and prelingually deafened children can bene it from a CI [1]. The goal of the present study is to describe the epidemiological characteristics, the surgical approach and the outcomes of our experience regarding the aural rehabilitation by cochlear implantation.
Heterogeneous Information Networks: the Past, the Present, and the Future

In 2011, we proposed PathSim to systematically define and compute similarity between nodes in a heterogeneous information network (HIN), where nodes and links are from different types. In the PathSim paper, we for the first time introduced HIN with general network schema and proposed the concept of meta-paths to systematically define new relation types between nodes. In this paper, we summarize the impact of PathSim paper in both academia and industry. We start from the algorithms that are based on meta-path-based feature engineering, then move on to the recent development in heterogeneous network representation learning, including both shallow network embedding and heterogeneous graph neural networks. In the end, we make the connection between knowledge graphs and HINs and discuss the implication of meta-paths in the symbolic reasoning scenario. Finally, we point out several future directions.