Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationships among Tear Film Stability, Osmolarity, and Dryness Symptoms

Purpose To examine the relationships among tear osmolarity, tear film stability, and several measures of dry eye (DE) symptoms in a multivariable analysis. Methods A cross-sectional study was conducted with 137 subjects (68 non–contact lens [CL] wearers and 69 soft CL wearers) recruited from a university campus. Tear breakup time (TBUT) was measured noninvasively (NITBUT) and with fluorescein (FTBUT). Tear osmolarity was measured by an osmometer. Dry eye symptoms were assessed using the Dry Eye Flow Chart and several different questionnaires. Results Subjects ranged in age from 18 to 67 years, with a mean of 28 years. Subjects had a mean (SD) osmolarity of 293 (10) mOsm/L, NITBUT of 14.1 (10.9) seconds, and FTBUT of 14.8 (12.6) seconds. Shorter NITBUT and FTBUT were significantly associated with female sex (p = 0.001 and p = 0.027, respectively) and Asian ethnicity (p = 0.030 and p = 0.004, respectively). There were no clinically significant relationships between tear osmolarity and FTBUT, NITBUT, or DE symptoms. Higher Dry Eye Flow Chart score (i.e., worse symptoms) was associated with older age (p < 0.001), female sex (p = 0.014), CL wear (p < 0.001), shorter NITBUT (p < 0.001), and shorter FTBUT (p = 0.028). The sensitivities and specificities for using clinical measurements to diagnose moderate to severe DE were as follows: osmolarity, 0.67 and 0.46, respectively; NITBUT, 0.72 and 0.52, respectively; and FTBUT, 0.68 and 0.57, respectively. Conclusions In a population of asymptomatic, mild and moderate DE patients, increased tear osmolarity was not significantly associated with reported symptom severity and frequency. Tear osmolarity, NITBUT, and FTBUT exhibited similar sensitivities and specificities when used to diagnose moderate to severe DE.
Quality impact due to initial loading, stalling, and video bitrate in progressive download video services

The paper targets the audiovisual quality assessment of progressive download type video services such as Video on Demand (VoD) and YouTube. To this aim, we investigate the quality impact due to initial loading, stalling, and video bitrate for High Definition (HD, 1920×1080 pixels) audiovisual sequences. The analysis is based on the results of three audiovisual subjective tests conducted in a laboratory environment. The paper extends the work described in previous studies by looking at high video resolution (HD) for short (30 s) and longer (45-60 s) test sequences, and by addressing the combined effect of initial loading, stalling and video bitrates on perceived quality. The distribution of stalling events within a video sequence and the recency effect are also analysed.
Dietary variability in the western black crested gibbon (Nomascus concolor) inhabiting an isolated and disturbed forest fragment in Southern Yunnan, China

Forest fragmentation and isolation can reduce the size of available habitat and lead to lower food availability for some primate species. The persistence of nonhuman primates in fragments depends largely on their ability to adjust their diet in response environmental change. The western black crested gibbon (Nomascus concolor) is distributed in northern Vietnam, northwestern Laos, and southwestern China, but little is known about its diet except from studies in the well‐protected forests of Mt. Wuliang and Mt. Ailao, central Yunnan. We studied food abundance and diet over 2 years in a small group surviving in an isolated and disturbed forest at Bajiaohe, southern Yunnan, and drew a comparison with the population at Dazhaizi in Mt. Wuliang. We found that gibbons at Bajiaohe consumed mostly fruit, but did not eat figs, unlike most other gibbon populations. Liana fruits and mature leaves were used as alternative foods during periods of tree fruit scarcity. Our results indicate that gibbons in Bajiaohe respond to habitat fragmentation and isolation by consuming a variety of plant species, depending on those that are locally available, and increasing time spent feeding on fruits of trees and lianas rather than increasing time spent consuming leaves. Am. J. Primatol. © 2013 Wiley Periodicals, Inc.
Uses and abuses of pulse oximetry.

o -0 cn, g0 Red 660 nm It is extraordinarily difficult to gue of a patient's arterial oxygenation s The ability to detect decreased hi oxygen saturation depends on m including circulatory state, skin pig haemoglobin concentration, am] colour and intensity. The introduc early eighties of pulse oximetry allk ably accurate objective assessment globin oxygen saturation of art( (Spo2), cheaply, non-invasively, very low morbidity. Apart from the objective indicati pulse oximetry may be described in that the technique fails and there if the pulsatility of the pulse decreases to below a critical lev information may be gained by the plethysmograph trace which enable entiation between the pulse wav artefacts. Indeed this author would to say that no pulse oximeter shoL unless a plethysmograph trace is di Knowledge of the principles o nique allows one to understand the and use the information displayed absorption spectra of normal ad globin in its saturated and desatu are shown in fig 1. Also shown are tion spectra of two common dyshae carboxyhaemoglobin and metha which lead to erroneous oxygen
Enhanced Semantic Interoperability by Profiling Health Informatics Standards

Summary Objectives: Several standards applied to the healthcare domain support semantic inter-operability. These standards are far from being completely adopted in health information system development, however. The objective of this paper is to provide a method and suggest the necessary tooling for reusing standard health information models, by that way supporting the development of semantically interoperable systems and components. Methods: The approach is based on the definition of UML Profiles. UML profiling is a formal modeling mechanism to specialize reference meta-models in such a way that it is possible to adapt those meta-models to specific platforms or domains. A health information model can be considered as such a meta-model. Results: The first step of the introduced method identifies the standard health information models and tasks in the software development process in which healthcare information models can be reused. Then, the selected information model is formalized as a UML Profile. That Profile is finally applied to system models, annotating them with the semantics of the information model. The approach is supported on Eclipse-based UML modeling tools. The method is integrated into a comprehensive framework for health information systems development, and the feasibility of the approach is demonstrated in the analysis, design, and implementation of a public health surveillance system, reusing HL7 RIM and DIMs specifications. Conclusions: The paper describes a method and the necessary tooling for reusing standard healthcare information models. UML offers several advantages such as tooling support, graphical notation, exchangeability, extensibility, semi-automatic code generation, etc. The approach presented is also applicable for harmonizing different standard specifications.
Salmonella enterica in Commercial Swine Feed and Subsequent Isolation of Phenotypically and Genotypically Related Strains from Fecal Samples

ABSTRACT The purpose of this study was to determine the occurrence and genotypic relatedness of Salmonella enterica isolates recovered from feed and fecal samples in commercial swine production units. Of 275 feed samples, Salmonella was detected in 10 feed samples that originated from 8 of 36 (22.2%) barns, with a prevalence of 3.6% (10/275 samples). In fecal samples, a prevalence of 17.2% was found at the early finishing stage (1,180/6,880 samples), with a significant reduction in prevalence (7.4%) when pigs reached market age (392/5,321 samples). Of the 280 Salmonella isolates systematically selected for further characterization, 50% of the feed isolates and 55.3% of the isolates of fecal origin showed similar phenotypes based on antimicrobial resistance patterns and serogrouping. About 44% of the isolates were multidrug resistant. Pulsed-field gel electrophoresis (PFGE) genotyping grouped the 46 representative isolates into five genotypic clusters, of which four of the clusters consisted of genotypically related isolates recovered from feed and fecal samples. The occurrence of genotypically related and, in some cases, clonal strains, including multidrug-resistant isolates in commercially processed feed and fecal samples, suggests the high significance of commercial feed as a potential vehicle of Salmonella transmission.
Interval-Specific Congenic Animals for High-Resolution Quantitative Trait Loci Mapping

Behavioral phenotypes (e.g., drug responses and withdrawal) are typically quantitative traits-characteristics that differ along a spectrum in the extent to which an individual possesses that characteristic. Such traits are determined by multiple genes, as well as by environmental factors and interactions among genes and environmental factors. The chromosomal regions containing these genes are commonly referred to as quantitative trait loci (QTLs). As described in the preceding article by Hitzemann and colleagues (pp. 270- 271), researchers have developed a variety of strategies to attain greater precision when mapping QTLs (Darvasi 1998; Talbot et al. 1999), which is necessary for unbiased genomewide approaches such as QTL mapping to be successful in ultimately identifying which gene(s) underlies a QTL's phenotypic influence. Among these, some approaches are clearly superior for fine mapping QTLs associated with behavioral traits. One such strategy employs specially bred animals known as interval-specific congenics (ISCs) (sometimes called small donor segment congenics). This article introduces the use of these animals in mapping QTLs associated with certain responses to alcohol.
Work Experiences, Job Involvement, and Quality of Work Life Among Information Systems Personnel

This study assesses the job involvement of 464 professionals and managers in the information systems (IS) field and investigates the role of involvement in influencing the quality of work life. Results show significant variation in the level of job involvement displayed by IS employees and differential patterns of relationships among the work variables for IS personnel with low, moderate, and high levels of job involvement. The findings indicate that involvement serves as a complex moderator role in the pattern of relationships of work experiences, and job characteristics with career expectations and career outcomes. It has both linear and non-linear relationships with sevearl of the study variables. While in some cases, high levels of job involvement tend to enhance the beneficial effects of work experiences on the quality of work life, in others such involvement tends to heighten the negative effects of role stressors. Implications of the findings and directions for future research are discussed.
A novel p53‐inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

The biological effects of the p53 tumor suppressor protein are elicited, at least in part, through sequence‐specific transactivation of a battery of target genes. The differential display method was employed towards identifying additional p53 target genes, with emphasis on genes whose induction may contribute to p53‐mediated apoptosis. We report here the cloning of a novel p53‐inducible gene, designated PAG608. PAG608 transcripts are induced by DNA damage in a p53‐dependent manner. PAG608 encodes a nuclear zinc finger protein, which appears to localize preferentially to nucleoli when expressed at moderate levels in transfected cells. Transient overexpression of PAG608 in human tumor‐derived cells leads to distinctive changes in nuclear morphology, and can promote apoptosis. Together with additional p53 target genes, PAG608 may therefore play a role in mediating the biological activities of p53.
The Complete Genome Sequence of Trueperella pyogenes UFV1 Reveals a Processing System Involved in the Quorum-Sensing Signal Response

ABSTRACT We present here the complete genome sequence of Trueperella pyogenes UFV1. The 2.3-Mbp genome contains an extremely interesting AI-2 transporter and processing system related to the quorum-sensing signal response. This specific feature is described in this species for the first time and might be responsible for a new pathogenic behavior.
Radiofrequency ablation of experimental bone metastases in nude rats.

PURPOSE Animal models are indispensable to investigate bone metastasis and to test different preclinical therapy options. Radiofrequency ablation is an upcoming technique for palliating pain from bone metastases. The aim of this study was to generate osteolytic lesions and to enable a technique to achieve access to the bone to successfully carry out radiofrequency ablation. MATERIALS AND METHODS Human breast cancer cell line MDA-MB-231 (10(5) tumor cells) was implanted into the femur of 10 nude rats using a drill hole after arthrotomy of the knee joint and opening of the femur through the notch. Weekly CT- and MRI-scans were performed to document number and size of bone metastases. Radiofrequency ablation (22G bipolar and impedance-controlled RF-applicator, 2-4 Watt, 3 min application time) was carried out. One week after RFA, the animals were sacrificed and macroscopic and histological examination followed. For statistical analysis, paired comparison procedures were used. RESULTS Inoculation of the tumor cells was well tolerated. The mean time of the surgical procedure was 6 minutes. All animals developped local bone metastases. Mean time to metastasis was 8 weeks (range 7-10 weeks) after tumor cell implantation. No leakage of tumor cells and no soft part metastases occurred. Radiofrequency ablation was performed without complications. Imaging showed a complete ablation of the bone tumor in all rats. Histological findings confirmed a circular necrosis with an extensive destruction of tumor cells leaving a necrosis cavity. CONCLUSION The experimental model presented here describes the first time the ability to carry out radiofrequency ablation in nude rats with intrafemoral induced osteolytic metastases of human breast cancer. RFA in human breast cancer cell line in nude rats is a feasible and useful possibility to evaluate and to test different RF-procedures. Additional treatment options like local chemotherapy or chemoembolization can be performed.
Increasing Prevalence of Cerebral Palsy Among Very Preterm Infants: A Population-Based Study

OBJECTIVES. It is unclear whether declines in neonatal and infant mortality have led to changes in the occurrence of cerebral palsy. We conducted a study to examine and investigate recent temporal changes in the prevalence of cerebral palsy in a population-based cohort of very preterm infants who were 24 to 30 weeks of gestational age. METHODS. A population-based cohort of very preterm infants who were born between January 1, 1993, and December 31, 2002, was evaluated by the Perinatal Follow-up Program of Nova Scotia. Follow-up extended to age 2 years to ascertain the presence or absence of cerebral palsy and for overall survival. Infant survival and cerebral palsy rates were compared by year and also in two 5-year periods, 1993–1997 and 1998–2002. Logistic regression analyses were used to identify factors that potentially were responsible for temporal changes in cerebral palsy rates. RESULTS. A total of 672 liveborn very preterm infants were born to mothers who resided in Nova Scotia between 1993 and 2002. Infant mortality among very preterm infants decreased from 256 per 1000 live births in 1993 to 114 per 1000 live births in 2002, whereas the cerebral palsy rates increased from 44.4 per 1000 live births in 1993 to 100.0 per 1000 live births in 2002. Low gestational age, postnatal dexamethasone use, patent ductus arteriosus, severe hyaline membrane disease, resuscitation in the delivery room, and intraventricular hemorrhage were associated with higher rates of cerebral palsy, whereas antenatal corticosteroid use was associated with a lower rate. CONCLUSION. Cerebral palsy has increased substantially among very preterm infants in association with and possibly as a consequence of large declines in infant mortality.
Khiops : outil de préparation et modélisation des données pour la fouille des grandes bases de données

Resume. Khiops est un outil de preparation des donnees et de modelisation pour l’apprentissage supervise et non supervise. L’outil permet d’evaluer de facon non parametrique la correlation entre tous types de variables dans le cas non supervise et l’importance predictive des variables et paires de variables dans le cas de la classification supervisee. Ces evaluations sont effectuees au moyen de modeles de discretisation dans le cas numerique et de groupement de valeurs dans le cas categoriel, ce qui permet de rechercher une representation des donnees efficace au moyen d’un recodage des variables. L’outil produit egalement un modele de scoring pour les tâches d’apprentissage supervise, selon un classifieur Bayesien naif avec selection de variables et moyennage de modeles. L’outil est adapte a l’analyse des grandes bases de donnees, avec des centaines de milliers d’individus et des dizaines de milliers de variables, et a permis de participer avec succes a plusieurs challenges internationaux recents.
An X-band SIW-DGS bandpass filter with improved stopband performance

In this paper, a substrate integrated waveguide (SIW)-to-defected ground structure (DGS) bandpass filter with moderate fractional bandwidth and improved stopband performance is proposed and demonstrated for X-band radar application. Design considerations including the design approach are addressed. A third-order filter with a passband of 8.8-10.1 GHz is fabricated on a single-layer Rogers RT/Duroid 5880 substrate using linear arrays of metallized via-holes by a standard printed circuit board process. Measured results of the filter agree very well with the simulated results, showing the in-band insertion loss is 1.3 dB or less, and in-band return loss is better than 20dB, respectively. The stopband rejection in the frequency band of 12-22 GHz is better than 35 dB.
Results of One-Year Follow-Up Examinations after Intravitreal Bevacizumab Administration for Chronic Central Serous Chorioretinopathy

Background: Our purpose was to report the results of 1-year follow-up examinations after intravitreal bevacizumab injection for the treatment of chronic central serous chorioretinopathy (CSC). Methods: Five eyes in 5 patients with chronic CSC were intravitreally injected with 1.25 mg/0.05 ml of bevacizumab. The need for retreatment was evaluated if spectral-domain optical coherence tomography showed the presence of subretinal fluid at the time of a 1-month follow-up examination. Best-corrected visual acuity and central foveal thickness were compared between baseline and 1 year after the first injection. Results: The mean logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity improved from 0.23 ± 0.46 to 0.17 ± 0.47 and the mean central foveal thickness significantly decreased from 323 ± 98 µm to 171 ± 63 µm (p < 0.05). Conclusion: The intravitreal injection of bevacizumab is well tolerated in maintaining vision and reducing serous retinal detachment in patients with chronic CSC, as evaluated at a 1-year follow-up examination.
Expression of Fas ligand is an early event in colorectal carcinogenesis

Fas ligand (FasL) is expressed in many cancers and plays an important role in establishing immunologically privileged environments that allow tumors to escape the host's immune surveillance. We investigate the expression of FasL in human colorectal cancer and colorectal adenoma and elucidate the relationship between FasL expression and the clinicopathological characteristics of colorectal cancers.
The Validity of the Danish Version of the Canadian Occupational Performance Measure

Purpose To establish the construct validity of the Danish version of the Canadian Occupational Performance Measure (COPM). Methods A cross-sectional study was performed in two settings, a regional hospital and a rehabilitation centre in a community. Including adult clients with a variety of diagnoses, we assessed construct validity by correlating the COPM to the Occupational Self-Assessment (OSA), the five-item World Health Organization Well-Being Index (WHO-5), and the EuroQol-five domain-five level questionnaire (EQ-5D-5L). Further examination of the comparability of the OSA and the COPM was performed in two ways. First, an interrater agreement of the theoretical correlation of the 21 OSA items and the three areas of the COPM was conducted. Secondly, we examined the compliance between the prioritized occupational performance issues (OPIs) and items of the OSA prioritized for change. Results The study included a total sample of 112 participants with more than half of the participants (56%) recruited from the hospital. 109 participants had measurements for both COPM and OSA (44% males) with a mean age of 64.7 years (range 16-96 years). All correlations, between the COPM and the OSA, the WHO-5, and the EQ-5D-5L, were low or negligible (r < 0.50). Manual examination confirmed a difference in the constructs of the OSA and the COPM. This was demonstrated by a negligible interrater agreement between the items of the OSA and the areas of the COPM, and differences in the prioritized OPIs and OSA items, even if there were some resemblances, were found. Conclusions This study suggests that the construct of the COPM provides data different to those obtained with the standardized measurements included for comparison. The present study supports the assumption that the COPM can detect unique OPIs that clients want to do, need to do, must do, or are not satisfied with the way they do.
Contributions of heredity and environment to manifestations of psycho-neurosis.

THE PURPOSE of this paper is to review critically recent evidence on the relations between heredity and environment in producing psycho-neuroses. A pedigree will then be given of psycho-neuroses in an Anglo-American Jewish family. This will indicate not only the mode of inheritance but also suspected causes leading to the manifestation of various types of neurotic condition in affected individuals. All previous work has been based on population sampling, no individual family pedigrees having been studied intensely. Psycho-neuroses include hysteria, neurasthenia, psychasthenia and mental short of insanity; Gates out in assessing the hereditary in their manifestation many psycholo-gists ignore the hereditary aspects. Gates considered it impossible to determine the nature or extent hereditary constitutionally to hereditary or "constitutional
Integrating Mental Health Services into Primary HIV Care for Women: The Whole Life Project

The high rate of mental health problems in HIV-infected women jeopardizes the health of this vulnerable population, and constitutes a mandate for integrating mental health services into HIV primary care. The Whole Life project—a collaboration of the departments of Psychiatry and Obstetrics/Gynecology at the University of Miami School of Medicine—successfully integrated mental health services into primary HIV care for women. This article describes the conceptual framework of the integration, implementation strategies, effects of the service integration, and lessons learned. Funded by the Health Resources and Services Administration (HRSA) as a Special Program of National Significance (SPNS), Whole Life efforts have been sustained beyond the demonstration funding period as a result of the changes brought about in organizational structures, service delivery, and the providers' conceptualization of health for HIV-infected women.