Miracle-dz/UniFAR-FTUs huggingface dataset:
Protamine neutralization of intravenous and subcutaneous low-molecular-weight heparin (tinzaparin, Logiparin™). An experimental investigation in healthy volunteers

The aim of the present study was to investigate whether tinzaparin sodium (a low-molecular-weight heparin (LMWH)) was fully and permanently neutralized in vivo in man by protamine sulphate (PS) after intravenous (i.v.) or subcutaneous (s.c.) injection. Fifty healthy adults equally divided in five age- and sex-matched groups were included. The groups received 50 IU unfractionated heparin (UH)/kg body weight (b.w.) i.v. , 50 anti-factor Xa (anti-Xa) IU tinzaparin/kg b.w. i.v. , 75 anti-Xa IU tinzaparin/kg b.w. s.c, 175 anti-Xa IU tinzaparin/kg b.w. s.c, or 1 ml of saline s.c PS was given as a 10 min infusion in a dose of 1 mg/100 IU of heparin in the four first groups while 0 . 5 mg PS/kg b.w. was given in the placebo group. In the i.v. groups PS was administered 45 min after the heparin injection, and in the s.c. groups 180 min post-heparin injection. In the UH group PS fully and permanently neutralized all three activities. In the i.v. tinzaparin group PS reversed 80% of the anti-Xa activity, while the anti-IIa and aPTT activities were fully reversed. A slight, but statistically significant, increase in anti-Xa and anti-IIa activities were seen following i.v. tinzaparin. In the s.c. groups 60–65% of the observed peak anti-Xa activity was neutralized, anti-IIa was almost completely reversed, and aPTT returned nearly to baseline values. A gradual return of the anti-Xa activity (65–75%), anti-IIa activity (55%) and aPTT activity (35–45%) was seen in the s.c. groups 3 h after reversal compared with the observed peak values. A continuous absorption of tinzaparin from the s.c. depot is presumably the cause of the returned activity. PS caused an 8–27% transient drop in the platelet count in all groups. This study confirms that the anti-Xa activity following i.v. and s.c. administration of tinzaparin (a LMWH) is only partially neutralizable by protamine. This is not due to insufficient dosages of the antidote, as an excess of protamine could be demonstrated ex vivo immediately after the protamine infusion. The present results suggest that protamine neutralization of tinzaparin given s.c. should be obtained with intermittent injections or continuous infusion.
All-optical reshaping in a 160-Gb/s OTDM receiver using an XAM gate followed by an SPM discriminator

We demonstrated a 160-Gb/s optical time-domain multiplexing receiver with a pulse-reshaping function using a cross-absorption modulation gate followed by a self-phase modulation based pulse-level discriminator. We confirmed gate-performance improvement by the discriminator for demultiplexing from 160 to 10 Gb/s and demonstrated pulse-level stabilization for all tributary channels.
Plants and Productivity in International Trade

We reconcile trade theory with plant-level export behavior, extending the Ricardian model to accommodate many countries, geographic barriers, and imperfect competition. Our model captures qualitatively basic facts about U.S. plants: (i) productivity dispersion, (ii) higher productivity among exporters, (iii) the small fraction who export, (iv) the small fraction earned from exports among exporting plants, and (v) the size advantage of exporters. Fitting the model to bilateral trade among the United States and 46 major trade partners, we examine the impact of globalization and dollar appreciation on productivity, plant entry and exit, and labor turnover in U.S. manufacturing. (JEL F11, F17, O33)
BAROREFLEX OPEN-LOOP GAIN DURING 24 HOURS.

During the second half of the twentieth century the opinion prevailed in the scientific community that the role of baroreflex in hypertension was negligible despite the fact that baroreflex is the most important regulatory mechanism of blood pressure. This opinion was supported by the observation of baroreflex resetting. The resetting is in other words a shift of the curve of the relationship between carotid sinus pressure and systemic arterial pressure to the higher values of systemic arterial pressure. This opinion was not shared by all scientists; the most prominent opponent, Professor Slight, claimed that it is clear that all forms of hypertension – whether primary or essential or secondary to renal, hormonal, or environmental influences – have a neurogenic component [1]. More recent evidence suggests that neural mechanisms, particularly impairment of arterial baroreflexes, play an important part. In the recent years the long-term control of blood pressure was re-evaluated [2]. The recent opinion is based on chronic electrical stimulation of carotid baroreceptor afferent fibres, on re-evaluation of the time of chronic resetting lasting several days according to the more recent experiments. Furthermore, decreased baroreflex gain appears to precede hypertension. Years ago, baroreflex sensitivity was regarded to correspond to the capability of the parasympathetic nervous system to react to a gross stimulus and thus to concern primarily vagal reflexes [3]. The measurement of baroreflex heart rate sensitivity in ms/mmHg was the adequate method. To study the blood pressure control function of baroreflex the determination of baroreflex gain is necessary. The founder of modern chronobiology, Professor Franz Halberg, demonstrated many years ago that a reliable diagnosis of blood pressure disorders can be made on the basis of at least 24-hour-blood pressure monitoring. (Recent studies of Prof. Halberg suggest seven-day monitoring to obtain reliable estimates [4].) The aim of the present paper was to determine the baroreflex open-loop gain during 24 hours in hypertensive patients and normotensive controls.
Olecranon stress fracture in a weight lifter: a case report

Stress fractures have been reported in the upper limb of sportspeople involved in upper limb dominated events. Olecranon stress fractures have been cited in baseball pitchers, javelin throwers, and gymnasts. The unusual case of a stress fracture of the olecranon in a young weight lifter is reported here. The minimally displaced stress fracture was treated with tension band and two Kirschner wires. The fracture healed in four months and the patient returned to light sports activity after six months.
Rangement d'objets multiboîtes : modèles et algorithmes

Un objet multiboite est compose de plusieurs parties identiques qui doivent etre rangees dans des boites differentes. La hauteur d'une boite est alors la somme des hauteurs des objets qu'elle contient. Ce concept generalise et englobe de nombreux problemes de la litterature de la recherche operationnelle. Une classification de ces modeles est proposee. Les bases theoriques sont posees. En particulier, la complexite pour les principaux types d'objets et objectifs est determinee. Une etude detaillee est effectuee lorsque les objets ont des largeurs constantes et que l'on veut minimiser la hauteur de la boite la plus haute. Des bornes inferieures, des heuristiques avec de tres bonnes garanties de performance et un algorithme genetique sont proposes pour resoudre ce modele. Leurs comportements theoriques et experimentaux sont analyses.
Evaluation of cardiac risk marker levels in obese and non-obese patients with polycystic ovaries

Abstract Objective: To compare cardiac risk markers such as asymmetric dimethyl arginine (ADMA), C-reactive protein (CRP), homocystein (Hcy), plasminogen activator inhibitor-1 (PAI–1), vascular endothelial growth factor (VEGF), angiopoietin-related growth factor 6 (ANGPTL6) in obese and non-obese patients with polycystic ovary syndrome (PCOS). Study design: Thirty obese (BMI >30 kg/m2) and 30 non-obese (BMI < 30 kg/m2) patients diagnosed with PCOS and 30 age-matched healthy controls were included in the study. The ages of subjects were varying between 18 and 30 years. Serum ADMA, CRP, Hcy, PAI-1, VEGF and ANGPTL6 levels were analyzed for each subject. Results: Serum ADMA, CRP, Hcy, PAI-1, VEGF and ANGPTL6 levels were significantly elevated in obese and non-obese women with PCOS in comparison to control subjects (p < 0.05). This elevation was more obvious in the obese PCOS group than in the other group. Conclusions: Cardiovascular risk markers such as ADMA, CRP, Hcy, PAI-1, VEGF and ANGPTL6 levels are elevated in women with PCOS.
Notice of RetractionThe application of MES in electronic assembly industry based on RFID

On the analysis of the current situation of electronic assembly industry, this paper puts forward a manufacturing execution system based on RFID which apply to electronic assembly production process. The implementation of this system adopts a multi-tier architecture and successfully combines the RFID application and the MES, finally completes the binding between tag and product information, then discuss the functional requirements, system hardware structure and software composition. This system is successfully applied in the Electronic assembly industry. It shows that the system can greatly promote manufacturing management capability, improve the production efficiency and achieve optimization of the whole production process.
A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search.

Essential hypertension (EH) is a complex disorder that results from the interaction of a number of susceptibility genes and environmental factors. We studied an isolated Sardinian village (Talana) in which the prevalence of hypertension is comparable to that in most Western populations. Talana exhibits features, such as slow demographic growth, high inbreeding, a low number of founders, stable lifestyle and culture, and accurate genealogical records, that make it suitable for the study of complex disorders. Clinical assessment of the entire adult population (N= approximately 1,000) identified approximately 100 hypertensive subjects. For our study, we selected the individuals with the most-severe EH (i.e., diastolic blood pressure >100 mm Hg), belonging to a single deep-rooted pedigree (12 generations), whose common ancestors lived in the 17th century. We performed a three-stage genomewide search using 36 affected individuals, by means of parametric linkage and allele-sharing approaches. LOD scores >1 were observed on chromosomes 1, 2, 13, 15, 17, and 19 (stage I). The most striking result was found in a 7.57-cM region on chromosome 2p24-p25. All five nonparametric linkage statistics estimated by the SimWalk2 program lie above the significance threshold of P<. 008 for the whole region. Similar significance was obtained for 2p24-25 when parametric linkage (LOD score 1.99) and linkage disequilibrium mapping (P=.00006) were used, suggesting that a hypertension-susceptibility locus is located between D2S2278 and D2S168. This finding is strengthened by a recent report of linkage with marker D2S168 in a hypertensive sib-pair sample from China.
The modern financial corporation and global policy

This chapter focuses on the roles and importance of the modern financial corporation in the operation of global policy-making. It describes the prominence of the financial corporation as a key actor within political economy scholarship, pointing out that financial corporations are often considered to be qualitatively distinct from other kinds of interest groups in general, and even from organized business. The chapter then delineates several key functions of financial corporations as agents of great importance within global policy-making. First, financial corporations can influence policy through their normal business operations and the structural prominence that they exhibit as a result. Second, they can influence policy through their organized advocacy, both individually and through collective efforts with other firms. Third, financial corporations can play an influential role in shaping global policy through their enmeshment within elite networks.
Second malignant neoplasms after cancer in childhood or adolescence. Nordic Society of Paediatric Haematology and Oncology Association of the Nordic Cancer Registries.

OBJECTIVE--To assess the relative risk of developing a second malignant neoplasm in people with a diagnosis of cancer in childhood and adolescence. DESIGN--Register based follow up study. SETTING--Populations of Nordic countries. SUBJECTS--30,880 people under the age of 20 with a first malignant neoplasm diagnosed during the period 1943-87. MAIN OUTCOME MEASURES--Relative and attributable risks of second malignant neoplasms by type of first cancer, age at first diagnosis, calendar period, sex, and country. Expected figures were based on the appropriate national incidence rates for cancer. RESULTS--247 cases of second malignant neoplasms were observed in 238 patients, yielding a relative risk for cancer of 3.6 (95% confidence interval 3.1 to 4.1). The risk changed significantly from 2.6 in people first diagnosed during the 1940s and 1950s to 6.9 among cohort members included in the late 1970s and 1980s. Increases were observed for most types of cancer. Highest levels of the relative risk were seen during the 10 years immediately after first malignant diagnosis. The incidence of second malignant neoplasms attributable to the first cancer and associated treatments, however, showed a consistent rise throughout the 45 years of follow up. CONCLUSION--The estimated risks for a second malignant neoplasm were significantly lower than those found in most large hospital based studies but compatible with the results from a similar population based study in the United Kingdom. Extent of risk and cancer pattern were similar among the Nordic countries and are believed to be representative for a large part of the European population.
Determinations of Relative Timing of Near-Earth Substorm Onset and Tail Reconnection

Several studies have recently been performed that are directed towards determining the timing of near-Earth neutral line (NENL) formation in the tail relative to substorm onset. These studies are reviewed here. It is found that they are all consistent with each other and that they show that NENL formation does not occur prior to substorm onset in the inner plasma sheet. This result is inconsistent with the fundamental premise of the new NENL substorm model that flows from a NENL lead to substorm onset in the inner plasma sheet well earthward of the NENL. Despite not occurring prior to substorm onset, NENL formation is clearly an important aspect of substorms. It is suggested that consideration be given to the possibility that NENL formation may be a result of, rather than a cause of, current wedge initiation in the inner plasma sheet. It is also suggested that understanding is needed of why signatures of NENL formation are often not observed within the plasma sheet, even when spacecraft are located within the longitude range of current wedge formation.
Substratum preferences of motor and sensory neurons in postnatal and adult rats

After peripheral nerve injuries, damaged axons can regenerate but functional recovery is limited by the specific reinnervation of targets. In this study we evaluated if motor and sensory neurites have a substrate preference for laminin and fibronectin in postnatal and adult stages. In postnatal dorsal root ganglia (DRG) explants, sensory neurons extended longer neurites on collagen matrices enriched with laminin (~50%) or fibronectin (~35%), whereas motoneurons extended longer neurites (~100%) in organotypic spinal cord slices embedded in fibronectin‐enriched matrix. An increased percentage of parvalbumin‐positive neurites (presumptive proprioceptive) vs. neurofilament‐positive neurites was also found in DRG in fibronectin‐enriched matrix. To test if the different preference of neurons for extracellular matrix components was maintained in vivo, these matrices were used to fill a chitosan guide to repair a 6‐mm gap in the sciatic nerve of adult rats. However, the number of regenerating motor and sensory neurons after 1 month was similar between groups. Moreover, none of the retrotraced sensory neurons in DRG was positive for parvalbumin, suggesting that presumptive proprioceptive neurons had poor regenerative capabilities compared with other peripheral neurons. Using real‐time PCR we evaluated the expression of α5β1 (receptor for fibronectin) and α7β1 integrin (receptor for laminin) in spinal cord and DRG 2 days after injury. Postnatal animals showed a higher increase of α5β1 integrin, whereas both integrins were similarly expressed in adult neurons. Therefore, we conclude that motor and sensory axons have a different substrate preference at early postnatal stages but this difference is lost in the adult.
Enhancing and Accelerating the Pace of Autism Research and Treatment

In a previous In FOCUS column, Kimball and Smith (2007) nicely articulated the benefits and challenges of creating computer technology to support individuals with autism. They also provided a well-devised three-point plan to stimulate and support progress in technology development for this population. As a follow-up to their column, the current offering expands the discussion by (a) highlighting additional technologies emerging in the field (and as available, providing sample citations or URLs to exemplify each technology), (b) detailing the many ways these innovative technologies can be used to enhance and accelerate the pace of autism research and treatment, and (c) describing the Autism Speaks–Innovative Technology for Autism (ITA) Initiative as a resource to complement and aid Kimball and Smith’s call for further technology development. Although Kimball and Smith (2007) mentioned computer software for persons with autism, there are several additional innovative technologies being developed for this population that utilize the Internet; audio and video recorders; electronic sensing technology; computer architecture, hardware, and software; virtual reality; and robotics. These technologies, alone or in conjunction, can be used beneficially in a number of critical areas affecting individuals with autism, their families, and the professionals who support them.
Effects of microsite conditions on seedling establishment on the foreland of Coleman Glacier

Questions: How do physical microsite conditions of microsites affect germination and seedling survival in different successional stages? Do different species germinate in similar microsites in a given successional stage? Location: Coleman Glacier foreland, Mount Baker, Washington State, USA. Methods: Two methods were used to characterize safe sites. 1. Grids of 300 10 cm × 10 cm plots were located in four different age classes on the foreland. 2. 105 pairs of plots, with and without seedlings of Abies amabilis , were located in each age class. For each plot we identified all seedlings and all individuals < 1 m tall. Microsite characteristics such as topography and presence of rocks or woody debris were noted for each plot. Microsite characteristics were compared between plots with and without each species. In addition we examined the effect of distance from seed sources on the presence of Alnus viridis seeds and seedlings in a newly disturbed area. Results: In early successional sites, seedlings of several species were positively associated with depressions and presence of rocks, and negatively associated with ridges. Patterns were generally consistent among species. In later succession, seedlings were not significantly associated with any microsite characteristics. For Alnus viridis, seed density decreased with distance from seed sources but seedling density did not. Conclusions: Because of harsh conditions in early succession, physical microsites are important, and most species have similar microsite requirements. In later succession, physical microsites characteristics are not as important and are more variable. Microsites appear to be more important than seed rain in controlling the distribution of Alnus viridis in early succession.
Earnings Management and Mergers and Acquisitions

This chapter investigates whether Italian-listed companies involved in mergers and acquisitions (M&A) during the period 2009–2017 manipulated earnings through recourse to discretionary accruals in response to financial market competition. Interest in the possible effects of competition on earnings management practices follows the considerable attention attracted by the effects of business combinations on disclosure quality and reliability. M&A represents an opportunity for managers to manipulate financial reports and to deliver misleading market information in order to enhance company reputation and attract funds from investors. This empirical analysis demonstrates that Italian-listed companies involved in M&A used goodwill as a discretionary accrual for managing earnings. The findings indicate that the increasing level of financial market competition between Italian-listed companies prompted major recourse to earnings management practices based on discretionary accruals.
What are capital markets telling us about the banking sector

As we all know, in response to the Great Financial Crisis of 2008–09, regulators pursued ambitious financial reforms to make the financial system more resilient to systemic risks. A key element is a significant increase in the quantity and quality of regulatory capital. While Basel III is still being completed – full implementation is scheduled for 2019 – these more stringent regulatory standards have already improved banks’ capital structure. For example, for the major banks monitored by the Basel Committee, CET1 capital ratios (CET1/RWA) increased, on average and on a fully loaded basis, from about 7% in 2011 to 11.8% at end-2015.1 During the same period, leverage ratios rose from about 3.5% to 5.6% on average. Let me remind you that the minimum capital for CET1 is 4.5% and that the target capital (minimum plus the conservation buffer) is 7%; actual capital ratios for most banks significantly exceed these requirements.
How the distribution of the number of items rated per user influences the quality of recommendations

With an ever-increasing amount of information made available via the Internet, it is getting more and more difficult to find the relevant pieces of information. Recommender systems have thus become an essential part of information technology. Although a lot of research has been devoted to this area, the factors influencing the quality of recommendations are not completely understood. This paper examines how the quality of the recommendations made by collaborative filtering recommender systems depends on the distribution of the number of items rated per user. Specifically, we show that its skewness plays an important role for the quality attained by an item-based collaborative filtering algorithm.
HR Practices in PTCL: A Case Study of BANNU District)

This thesis elaborates the Human Resource practices and their implications for big organizations and in my case especially the PTCL about how Human Resource is contributing the organization.In the first section a brief introduction of the organization in study has been provided. How it was introduced /how it has gone through various lite eyeless. In the section after the introduction working of an existing HR Practices has been elaborated. The gaps have been identified and solutions have been front forwarded in areas where there are deficiencies. The main aim of this study is to familiarize the future students and researchers with contemporary HR Practices either adopted from international organizations for developed locally. A combination of analysis techniques have been used whereby we can term it general specific and management respectively. Keywords : PTCL, Bannu, Case Study.HR Practices.