Miracle-dz/UniFAR-FTUs huggingface dataset:
Grading of Surgeon Technical Performance Predicts Postoperative Pancreatic Fistula for Pancreaticoduodenectomy Independent of Patient-related Variables

Objective: To evaluate and quantify surgical skill by grading surgical performance of the pancreaticojejunostomy from robotic pancreaticoduodenectomies (RPDs). We hypothesized that video grading of surgical performance would contribute to estimating risk of postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy. Background: POPF majorly contributes to pancreaticoduodenectomy morbidity. Risk scores [Fistula Risk Score (FRS) and Braga] derived from patient variables are validated for predicting POPF. Birkmeyer et al showed assessment of surgical proficiency is an important component of outcomes. Methods: POPF was diagnosed using International Study Group definition. Technical performance of robotic pancreaticojejunostomy video was graded by 2 blinded surgeons using: (1) pancreaticojejunostomy step-by-step variables [PJ-specific variables (PJVs); max = 115]; and (2) the Objective Structured Assessment of Technical Skills (OSATS) score. Results: One hundred thirty-three pancreaticojejunostomies were analyzed. POPF was 18%. Higher FRS (P = 0.011) and Braga (P = 0.041) scores predicted POPF. Graders’ subjective prediction did not correlate with FRS/Braga scores. Grader 1 scores (P = 0.043), but not grader 2 (P = 0.44), predicted POPF. PJV scores >105 were predictive of POPF (P = 0.039). Scoring only PJV duct-to-mucosa stitches (max = 50) was highly predictive of POPF (P = 0.0053). Higher OSATS scores were associated with a decreased rate of POPF (P = 0.022). On multivariate analysis, adding technical scoring to statistically significant patient variables (ie, gland texture) improves the model and can independently predict POPF. The strongest predictive model for POPF consisted of soft gland (odds ratio = 18.28, 95% confidence interval = 2.19–152.57) and low OSATS (odds ratio = 0.82, 95% confidence interval = 0.70–0.96). OSATS, modeled with FRS or Braga scores, independently predicted POPF. Conclusions: This is the first study to demonstrate that technical scoring of a surgeon's performance independently predicts patient outcomes in pancreatic surgery. Future studies should consider how to validate and incorporate technical metrics.
Performance analysis of Hoeffding trees in data streams by using massive online analysis framework

Present work is mainly concerned with the understanding of the problem of classification from the data stream perspective on evolving streams using massive online analysis framework with regard to different Hoeffding trees. Advancement of the technology both in the area of hardware and software has led to the rapid storage of data in huge volumes. Such data is referred to as a data stream. Traditional data mining methods are not capable of handling data streams because of the ubiquitous nature of data streams. The challenging task is how to store, analyse and visualise such large volumes of data. Massive data mining is a solution for these challenges. In the present analysis five different Hoeffding trees are used on the available eight dataset generators of massive online analysis framework and the results predict that stagger generator happens to be the best performer for different classifiers.
Fractal FSS: a novel dual-band frequency selective surface

The multiband properties of self-similar fractals can be advantageously exploited to design multiband frequency selective surfaces (FSS). A Sierpinski dipole FSS has been analyzed and measured and the results show an interesting dual-band behavior. Furthermore a near-field measurement technique is applied to characterize the FSS response to different angles of incidence. Finally, it is shown that it is possible to tune the FSS response by properly perturbating the geometry of the Sierpinski dipole.
Circulating serum levels of angiogenic factors and vascular endothelial growth factor receptors 1 and 2 in melanoma patients

Angiogenesis is essential for tumor progression and metastasis; however, the angiogenesis regulators that are biologically relevant for melanoma are still unknown. In this study, we analyzed the circulating serum levels of potent angiogenic factors, including vascular endothelial growth factor (VEGF), angiogenin, transforming growth factor-&bgr;1 and VEGF receptors, VEGFR1 and VEGFR2, in human melanoma patients. One hundred and fourteen patients with histopathologically verified cutaneous melanoma at different stages and 30 healthy controls were investigated. Serum levels of angiogenic factors and VEGF receptors were quantitatively analyzed by solid-phase enzyme-linked immunosorbent assay. The age of the patients (61 men and 53 women) ranged from 18 to 80 years; median age was 51 years. Serum transforming growth factor-&bgr;1 (P<0.001), VEGF (P=0.006) and VEGFR1 (P=0.007) levels were significantly higher in patients with melanoma than in the control group. No significant differences, however, exist in the serum angiogenin and VEGFR2 levels between melanoma patients and the controls. The positive correlations of elevated serum levels of transforming growth factor-&bgr;1, VEGF and VEGFR1 with advanced stages of disease were found. Significant relationship was found only between serum levels of VEGF and VEGFR2. Elevated serum transforming growth factor-&bgr;1 (P<0.001) and VEGF levels (P=0.0012) were found to be poor prognostic factors. Serum level of angiogenin and VEGF receptors, however, had no effect on survival. Our data suggest that the angiogenic serum factors, including VEGF, transforming growth factor-&bgr;1 and VEGFR1, but not angiogenin and VEGFR2 were increased in melanoma patients, especially associated with advanced disease stages. The mechanism of VEGF regulation of angiogenesis may in part be due to enhanced proliferation of VEGFRs, especially VEGFR1.
Amplification of JNK Signaling Is Necessary To Complete the Murine Gammaherpesvirus 68 Lytic Replication Cycle

ABSTRACT Several studies have previously defined host-derived signaling events capable of driving lytic gammaherpesvirus replication or enhancing immediate-early viral gene expression. Yet signaling pathways that regulate later stages of the productive gammaherpesvirus replication cycle are still poorly defined. In this study, we utilized a mass spectrometric approach to identify c-Jun as an abundant cellular phosphoprotein present in late stages of lytic murine gammaherpesvirus 68 (MHV68) infection. Kinetically, c-Jun phosphorylation was enhanced as infection progressed, and this correlated with enhanced phosphorylation of the c-Jun amino-terminal kinases JNK1 and JNK2 and activation of AP-1 transcription. These events were dependent on progression beyond viral immediate-early gene expression, but not dependent on viral DNA replication. Both pharmacologic and dominant-negative blockade of JNK1/2 activity inhibited viral replication, and this correlated with inhibition of viral DNA synthesis and reduced viral gene expression. These data suggest a model in which MHV68 by necessity amplifies and usurps JNK/c-Jun signaling as infection progresses in order to facilitate late stages of the MHV68 lytic infection cycle.
Upregulation of tissue factor in monocytes by cleaved high molecular weight kininogen is dependent on TNF-and IL-1

Khan MM, Liu Y, Khan ME, Gilman ML, Khan ST, Bromberg M, Colman RW. Upregulation of tissue factor in monocytes by cleaved high molecular weight kininogen is dependent on TNFand IL-1 . Am J Physiol Heart Circ Physiol 298: H652–H658, 2010. First published December 4, 2009; doi:10.1152/ajpheart.00825. 2009. —Inflammatory bowel disease and arthritis are associated with contact activation that results in cleavage of kininogen to form high molecular weight kininogen (HKa) and bradykinin. We have previously demonstrated that HKa can stimulate inflammatory cytokine and chemokine secretion from human monocytes. We now show that HKa can upregulate tissue factor antigen and procoagulant activity on human monocytes as a function of time (1–4 h) and HKa concentration (75–900 nM). The amino acid sequence responsible to block HKa effects is G440–H455. The HKa receptor macrophage-1 (Mac-1; CD11b18) is the binding site as shown by inhibition by a monoclonal antibody to CD11b/18. Chemical inhibitors of JNK, ERK, and p38 signaling pathways block cell signaling, as does an inhibitor to the transcription factor NFB. A combination of monoclonal antibodies to TNFand IL-1 but neither alone inhibited the HKa induction of tissue factor. These results suggest that HKa mimics LPS by triggering a paracrine pathway in monocytes that depends on TNFand IL-1 . Antibodies to kininogen or peptidomimetics might be a useful and safe therapy in inflammatory diseases or sepsis involving cytokines.
Ziprasidone alternative for olanzapine-induced hyperglycemia.

TO THE EDITOR: Among currently available atypical antipsychotic agents, clozapine and olanzapine are most often associated with clinically problematic weight gain and new-onset type 2 diabetes mellitus (1). Ziprasidone, a benzisothiazolylpiperazine, is a relatively new atypical antipsychotic that has been shown to be less likely to produce weight gain (2). We report on a patient with olanzapine-induced weight gain and type 2 diabetes whose blood glucose level returned to normal after he discontinued olanzapine and started treatment with ziprasidone.
Um algoritmo inspirado em colônias de abelhas para otimização numérica com restrições

Os problemas de otimizacao estao presentes em diversas areas de atuacao da sociedade e o uso de algoritmos bio-inspirados para a resolucao de problemas complexos deste tipo vem crescendo constantemente. O Algoritmo Colonia de Abelhas Artificiais (ABC – do ingles Artificial Bee Colony) e um algoritmo bio-inspirado proposto em 2005 para a resolucao de problemas de otimizacao multimodais e multidimensionais. O fenomeno natural que inspirou o desenvolvimento do ABC foi o comportamento inteligente observado em colonias de abelhas, mais especificamente no forrageamento. O ABC foi proposto inicialmente para ser aplicado na resolucao de problemas sem restricoes. Este trabalho avalia o desempenho do ABC quando aplicado na resolucao de problemas de otimizacao com restricoes. Para o tratamento das restricoes, metodos de penalizacao serao incorporados ao ABC. Sao analisados diversos metodos de penalizacao, de diferentes tipos, com o objetivo de identificar com qual deles o algoritmo apresenta melhor desempenho. Alem disto, sao avaliadas possiveis limitacoes e cuidados que devem ser tomados ao combinar metodos de penalizacao ao ABC. O algoritmo proposto e avaliado atraves da resolucao de problemas de otimizacao encontrados na literatura. Varios experimentos computacionais sao realizados e graficos e tabelas sao gerados para demonstracao dos resultados obtidos que tambem sao discutidos.
Morphological and Functional Changes of the Small Intestine in Growth-Stunted Broilers

Lenhardt , a, ·. Moze‰: Morphological and Functional Changes of the Small Intestine in Growth-Stunted Broilers. Acta Vet. Brno 2003, 72: 353-358. The development of morphology and function of the small intestine was related to body weight changes in commercially bred broilers with free access to food. At days 16 and 36 of age the broilers were divided into four groups (12 broilers in each) with normal growth and with retarded growth and morphometric parameters (villous height and crypt depth) and the activity of brush-border-bound alkaline phosphatase (AP) in the duodenum and jejunum were determined. The results revealed significant villous atrophy and crypt hypertrophy (p < 0.001) as well as marked decrease of densitometrically determined AP activity (p < 0.001) in broilers with retarded growth as compared to normal growing control chickens during both periods under study. Our results indicate that these morphological and functional changes in the small intestine (despite free access to food) may result in impairing its absorptive capacity for normal body weight development. They may also be the underlying cause for the persistence of a decreased body weight in broilers in which the stunting syndrome had developed. Broiler, stunted growth, duodenum, jejunum, morphometry, brush border, enterocyte, alkaline
Constrained capacity and power allocation for MIMO Rayleigh fading channels

In this paper, we study the capacity of the multiple-input multiple-output(MIMO) fading channels with phase-shift keying(PSK) constellations. Assuming perfect channel state information(CSI) at the receiver, we derive an expression for the input-constrained capacity, and present an approximation method to estimate the constrained capacity. We also derive the optimal transmitter power allocation strategy that achieve this capacity gain under perfect CSI feedback. The transmitter can adapt its power to the current CSI to maximize the constrained capacity. Numerical results show that the proposed method can accurately estimate the capacity with less computation and the spatial power allocation becomes more important at low signal-to-noise ratio(SNR).
Le « contexte pédagogique » comme pré-requis à la notion de facette de texte

Résumé : Notre travail s’inscrit dans la perspective de création d’une base de textes indexés pédagogiquement pour l’enseignement des langues. Au cours de notre travail nous avons été amenés à consulter les nombreux travaux sur la description de ressources pédagogiques (Learning Object Metadata (LOM), Shareable Content Object Reference Model, Educational Modelling Language…). Cependant, aucune solution proposée ne semble viable pour la description de ressources brutes, a fortiori pour la description de textes en vue de leur utilisation dans l’enseignement des langues. En effet, les standards, quand ils s’intéressent à l’indexation de ressources (comme LOM, the Gateway to Educational Metadata ou Education Network of Australia Metadata) considèrent les propriétés dites pédagogiques comme intrinsèques aux objets. Or, nous avons pu montrer, à travers certains exemples et surtout par une consultation de plus d’une centaine d’enseignants, que les propriétés pédagogiques des textes dépendent en réalité étroitement du contexte dans lequel le texte va être utilisé : le contexte pédagogique. Dans notre cas, il regroupe toutes les informations relatives à l’exploitation du texte : les objectifs didactiques, bien sûr, mais aussi l'ensemble des caractéristiques du public (niveau, âge, centres d'intérêt, langue 1, etc.) et de l'institution (filière / diplôme, contraintes matérielles, etc.) Pour prendre en compte cette dynamicité des propriétés pédagogiques des textes, nous définissons la notion de facette d’un
Low-Cost Smith-Waterman Acceleration

Due to advancing technology, genetic sequencing has become cheaper over the years. This has caused the demand for computational power to grow even faster than Moore's law. To remedy this problem, we analyzed low-cost hardware solutions to parallelize the computational part of the genetic sequencing. We proposed a novel method for calculating the score matrix of the Smith-Waterman algorithm, which solves the bandwidth bottleneck in earlier solutions. This method calculates the score matrix differentially and a buffer keeps track of the maximum value. Due to the nature of the Smith-Waterman algorithm, the resulting implementation can do the calculations fully in parallel. Since it fits on an Artix 7 XC7A200T chip 908 times, this leads to more than a twelve-fold improvement in performance/price compared to modern supercomputing platforms.
A Probabilistic Generative Model for Latent Business Networks Mining

The structural embeddedness theory posits that a company’s embeddedness in a business network impacts its competitive performance. This highlights the theoretical and practical values toward business network mining and analysis. Given the fact that latent business relationships exist among companies, and these relationships continuously evolve over time, a manual approach for the discovery and analysis of business network is ineffective. Though numerous research has been devoted to social network discovery and analysis, relatively little research work is performed for business network discovery. Guided by the design science research methodology, the main contribution of our research is the design and development of a novel probabilistic generative model for latent business relationship mining. The proposed method can effectively and efficiently discover evolving latent business networks over time. Our experimental results confirm that the proposed method outperforms the vector space model based baseline method by 28% in terms of average AUC value.
An image retrieval system with color emotion query

The traditional content-based image retrieval technology can't map underlying image features to semantics, leading to a “semantic gap” between the needs of users and the retrieval results. In this paper, we implement a color image retrieval system based on color emotions. By analyzing the distribution of color emotion histograms of the same theme image, we build a similarity calculation model, and then we use regional growth algorithm and fast particle swarm algorithm to accelerate the computation, and improve the accuracy on relevant feedback. Ultimately we achieve an image classification model based on emotional semantics. The test image data is from 10 classes of Corel standard image database. Experiments show that the color emotion-based image retrieval system in this paper can effectively extract the image emotional features, achieve a preferable retrieval results.
Treatment of primary systemic vasculitis

The term primary systemic vasculitis encompasses a spectrum of disorders of unknown aetiology, in which there is inflammation of various types and sizes of blood vesselsl. Although there may be overlap between them, distinct clinico-pahtological syndromes can be recognized, depending in part on the size of vessel involved (table l)2*3. The small vessel vasculitides frequently affect glomerular capillaries, resulting in focal necrotising glomemlonephritis (FNGN), and we shall describe our experience of the management of these conditions.
Post-translational integration of tail-anchored proteins is facilitated by defined molecular chaperones

Tail-anchored (TA) proteins provide an ideal model for studying post-translational integration at the endoplasmic reticulum (ER) of eukaryotes. There are multiple pathways for delivering TA proteins from the cytosol to the ER membrane yet, whereas an ATP-dependent route predominates, none of the cytosolic components involved had been identified. In this study we have directly addressed this issue and identify novel interactions between a model TA protein and the two cytosolic chaperones Hsp40 and Hsc70. To investigate their function, we have reconstituted the membrane integration of TA proteins using purified components. Remarkably, we find that a combination of Hsc70 and Hsp40 can completely substitute for the ATP-dependent factors present in cytosol. On the basis of this in vitro analysis, we conclude that this chaperone pair can efficiently facilitate the ATP-dependent integration of TA proteins.
Prognostic Stratification of Patients With ST-Segment–Elevation Myocardial Infarction (PROSPECT): A Cardiac Magnetic Resonance Study

Background— Cardiac magnetic resonance (CMR) is a robust tool to evaluate left ventricular ejection fraction (LVEF), myocardial salvage index, microvascular obstruction, and myocardial hemorrhage in patients with ST-segment–elevation myocardial infarction. We evaluated the additional prognostic benefit of a CMR score over standard prognostic stratification with global registry of acute coronary events (GRACE) score and transthoracic echocardiography LVEF measurement. Methods and Results— Two hundred nine consecutive patients with ST-segment–elevation myocardial infarction (age, 61.4±11.4 years; 162 men) underwent transthoracic echocardiography and CMR after succesful primary percutaneous coronary intervention. Major adverse cardiac events (MACE) were assessed at a mean follow-up of 2.5±1.2 years. MACE occurred in 24 (12%) patients who at baseline showed higher GRACE risk score (P<0.01), lower LVEF with both transthoracic echocardiography and CMR, lower myocardial salvage index, and higher per-patient myocardial hemorrhage and microvascular obstruction prevalence and amount as compared with patients without MACE (P<0.01). The best cut-off values of transthoracic echocardiography-LVEF, CMR-LVEF, myocardial salvage index, and microvascular obstruction to predict MACE were 46.7%, 37.5%, 0.4, and 2.6% of left ventricular mass, respectively. Accordingly, a weighted CMR score, including the following 4 variables (CMR-LVEF, myocardial salvage index, microvascular obstruction, and myocardial hemorrhage), with a maximum of 17 points was calculated and included in the multivariable analysis showing that only CMR score (hazard ratio, 1.867 per SD increase [1.311–2.658]; P<0.001) was independently associated with MACE with the highest net reclassification improvement as compared to GRACE score and transthoracic echocardiography-LVEF measurement. Conclusions— CMR score provides incremental prognostic stratification as compared with GRACE score and transthoracic echocardiography-LVEF and may impact the management of patients with ST-segment–elevation myocardial infarction.
El control de sistemas ciberfísicos industriales: revisión y primera aproximación

espanolLos sistemas ciberfisicos industriales (ICPS) abarcan las cuestiones de diseno, modelado y analisis de los sistemas ciberfisicos con especial enfasis en las aplicaciones industriales. El paradigma de la Industria 4.0 y las cuestiones asociadas a la transformacion digital de la industria se pueden considerar un caso especial de ICPS. Uno de los pilares cientifico-tecnicos para tratar el modelado y control de los ICPS es la inteligencia computacional y todos los metodos y tecnicas agrupados dentro del control inteligente. En este trabajo se tratan algunos conceptos basicos de los ICPS, se presenta una aproximacion a las principales estrategias de control utilizadas y algunas aplicaciones reportadas en la literatura. EnglishCyber-Physical systems (CPS) are the new generation of intelligent systems, which gives greater importance to the interaction between the physical processes and the computational components than their predecessors. It has become one of the fundamental pillars of the fourth industrial revolution which has brought with it the emergence of new challenges in the design of their control systems. This paper deals with the basic concepts of CPS and industrial cyber-physical systems (ICPS), presents a review of the main control strategies used for its design
Substitutes for human cadaveric bone in maxillofacial rigid fixation research.

OBJECTIVE Various materials have been used as human bone substitutes in rigid fixation research. We hypothesize that these substitutes behave differently than human cadaveric bone in maxillofacial research. STUDY DESIGN Screw insertion torque and pull-out strength of titanium maxillofacial self-tapping bone screws (1.0 mm and 2.4 mm outer diameter) were measured in cadaveric mandible and in the following materials: bovine rib, porcine rib, photoelastic epoxy, red oak, and 2 types of synthetic mandibles. Results were tested for statistically significant differences (unpaired t test, P <.05) in comparison with human bone. RESULTS For 1.0-mm screws, statistically significant differences were found for the synthetic mandibles groups and oak groups for insertion torque and porcine rib for pull-out strength. For 2.4-mm screws, statistically significant differences were found for the porcine rib and oak groups for insertion torque and the bovine rib and epoxy groups for pull-out strength. CONCLUSION The results suggest that human bone can be simulated in fixation studies with bone substitute materials.