Miracle-dz/UniFAR-FTUs huggingface dataset:
Papanicolaou Smear and HPV Testing for Cervical Screening

Background. Since the adequacy of screening for pre-cancer and cervical cancer with Papanicolaou (Pap) smear alone has been questioned, a number of adjunctive tests have been evaluated. This study determined whether human papillomavirus (HPV) testing can improve cervical screening when performed coincident with cytologic sampling. Methods. Patients were evaluated by Pap smear, HPV testing, and colposcopy at two study centers. Screening with either Pap smear alone or in combination with HPV testing (Pap and HPV testing) was evaluated by colposcopy-directed biopsy as the highest diagnostic standard. Results. The Pap smear alone detected 8/27 (29.6%) cases of women with significant pathology (precancerous lesion and HPV infection) on biopsy, whereas the combination of Pap and HPV testing detected 24/27(88.8%) cases. (p ＜ 0.001). Patients for whom both test results were normal (negative Pap and HPV testing) were extremely unlikely to harbor significant pathology (less than 1% of those screened). Pap smear and HPV testing together was especially helpful in the detection of low- grade cervical lesions compared to the detection rate with Pap smear alone. Conclusions. These data indicate that HPV testing combined with Pap smear exam increases the accuracy of cervical screening. HPV testing appears to be particularly useful as a triage instrument in women with otherwise negative Pap smears. Further studies to evaluate the cost effectiveness of this combined screening protocol are needed. (Mid Taiwan J Med 2002;7:21-7)
A Privacy-Preserving Message Forwarding Framework with key caching for low latency Cloud of Things

: For exchanging messages over opportunistic exchanges in cloud calculating-empowered Internet of Things (IoT), opportunistic Cloud of Things (CoT) is encouraging for customers by means of an emergent conveying policy. In recent times, for predicting upcoming interactions by the determination of enlightening message promoting effectiveness as well as system quantity, several informally-awake structures have been placed onward, influencing consumers’ communal features as well as interaction account. Nevertheless, in the extrapolation procedure as well as communication phase of unprincipled CoT distinct secrecy remains commonly ignored. Towards assuring distinct secrecy as well as improving communication effectiveness, in this broadsheet, we develop a secrecy preservative communication promoting context aimed at unprincipled CoT. For improving transmission effectiveness of incurable customers, we mainly assemble twofold-level design of a cloud server. The proposed method can efficiently safeguard distinct secrecy through incorporating a safety-centered flexibility extrapolation procedure using an overpowering assessment procedure. This paper also introduces data key caching to reduce the latency during the transmission process. The proposed method outperforms the conventional methods.
1 5 N ov 2 01 9 A new CFT from N = ( 0 , 2 ) Landau-Ginzburg model

As a result, modular invariant partition functions of SU(2)k WZNW models and unitary Virasoro minimal models admit the celebrated ADE classifications [5–8]. If a CFT is described by a non-chiral coset model [9] involving SU(2) and U(1), its modular invariant partition function fits into the ADE classification. As such, one can find modular invariant partition functions for parafermion (PF) models SU(2)k/U(1)k [10] and N = 2 minimal models (MMs) (SU(2)k × U(1)2)/U(1)k+2 [11]. Furthermore, with N = (2, 2) supersymmetry, LandauGinzburg (LG) models with ADE quasi-homogeneous superpotential are described by the MMs of corresponding ADE type in the infra-red (IR) limit [12, 13]. On the other hand, the class of N = (0, 2) LG models is much richer because firstly they are chiral in general and secondly there is more freedom due to the Eand J-terms [14, §6]. Therefore, it is natural to ask how IR CFTs incorporate the richness of N = (0, 2) LG models by encoding the information of the Eand J-terms. In this Letter, we make a modest step towards understanding the LG/CFT correspondence with N = (0, 2) supersymmetry by studying the IR fixed point of a certain N = (0, 2) LG model along the line [15]. We will obtain its modular invariant partition function, which turns out to be beyond the ADE classification. Careful analysis of the Hilbert space will show that a part of the left-moving sector is described by a new CFT which is a close cousin of the parafermion model.
Hierarchy processing in human neurobiology: how specific is it?

Although human and non-human animals share a number of perceptual and cognitive abilities, they differ in their ability to process hierarchically structured sequences. This becomes most evident in the human capacity to process natural language characterized by structural hierarchies. This capacity is neuroanatomically grounded in the posterior part of left Broca's area (Brodmann area (BA) 44), located in the inferior frontal gyrus, and its dorsal white matter fibre connection to the temporal cortex. Within this neural network, BA 44 itself subserves hierarchy building and the strength of its connection to the temporal cortex correlates with the processing of syntactically complex sentences. Whether these brain structures are also relevant for other human cognitive abilities is a current debate. Here, this question will be evaluated with respect to those human cognitive abilities that are assumed to require hierarchy building, such as music, mathematics and Theory of Mind. Rather than supporting a domain-general view, the data indicate domain-selective neural networks as the neurobiological basis for processing hierarchy in different cognitive domains. Recent cross-species white matter comparisons suggest that particular connections within the networks may make the crucial difference in the brain structure of human and non-human primates, thereby enabling cognitive functions specific to humans. This article is part of the theme issue ‘What can animal communication teach us about human language? ’
Control metabólico en pacientes diabéticos ambulatorios de un hospital general

Objetivos: Describir el grado de control metabolico basado en los niveles de glicemia, hemoglobina glicosilada (HbA1C), presion arterial y perfil lipidico de los pacientes con diabetes mellitus tipo 2, atendidos ambulatoriamente en un hospital general. Material y metodos: Estudio descriptivo-retrospectivo de una serie de casos. Se revisaron las historias clinicas de 107 pacientes. Se recogieron variables demograficas, antecedentes cardiovasculares, tiempo de enfermedad, numero de controles por ano, variables antropometricas, hemoglobina glicosilada, perfil lipidico y presion arterial. Se establecio el grado de control metabolico mediante HbA1C, colesterol LDL y presion arterial. Resultados: El 51,4% de diabeticos mantuvo una glucosa basal entre 80 y 130 mg/dl, el 31,8% una hemoglobina glicosilada menor de 7%, el 68,2% un colesterol total menor de 200 mg/dl, el 37,4% el colesterol LDL inferior a 100 mg/dl, y el 40,2% trigliceridos menor a 150mg/dl. El 51,4% tuvo una presion arterial sistolica inferior a 130 mm Hg y el 73,8% una diastolica inferior a 80 mm Hg. Solo el 9,3% presento control metabolico adecuado tanto en niveles de HbA1C, colesterol LDL y presion arterial sistolica. Conclusiones: Solo el 9,3% de los pacientes diabeticos tipo 2 consiguio un control metabolico acorde a las recomendaciones de la Asociacion Americana de Diabetes.
A facile green approach for fabricating bacterial cellulose scaffold with macroporous structure and cell affinity

Bacterial cellulose holds great promise for tissue engineering, but its application is greatly limited due to the lack of large pores and poor cell affinity. In this study, macroporous bacterial cellulose was fabricated through the dissolution of gelatin microspheres, which were incorporated with bacterial cellulose during bacterial cellulose fabrication. Then, gelatin was immobilized onto bacterial cellulose surface via procyanidins crosslinking. The results confirmed that the scaffolds possessed interconnected macroporous structure, high porosity, good water uptake ability, and good mechanical properties. The results of evaluation of cells showed that cells migrated to the inner of macroporous affinitive bacterial cellulose and displayed better spreading as well as proliferation than that on pure bacterial cellulose surfaces. The macroporous affinitive bacterial cellulose show potential as a scaffold for tissue engineering.
THE EFFECT OF OREM BASED SELF-CARE PROGRAM ON PHYSICAL QUALITY OF LIFE IN MULTIPLE SCLEROSIS PATIENTS

چکیده: زمینه و هدف: بیماری مولتیپل اسکلروزیس یک بیماری مزمن و پیشرونده است که در حد زیادی کیفیت زندگی را تحت تاثیر قرار می‌دهد. این مطالعه با هدف تعیین تاثیر برنامه خودمراقبتی مبتنی بر الگوی اورم بر ابعاد جسمی کیفیت زندگی بیماران مبتلا به مولتیپل اسکلروزیس انجام گرفت. روش بررسی: در این مطالعه کارآزمایی بالینی، 70 بیمار مبتلا به مولتیپل اسکلروزیس عضو انجمن مولتیپل اسکلروزیس ایران (20 تا 40 ساله) به روش در دسترس انتخاب و بصورت تصادفی در دو گروه آزمون و شاهد (35 نفر آزمون و 35 نفر شاهد) قرار گرفتند. 8 جلسه برنامه آموزشی بر اساس نیازهای آموزشی بیماران و مبتنی بر الگوی اورم در طول سه ماه توسط بیماران گروه آزمون بکار گرفته شد. ابعاد جسمی کیفیت زندگی بیماران قبل و سه ماه بعد از اجرای برنامه با استفاده از مقیاس سنجش ابعاد جسمی کیفیت زندگی بیماران مولتیپل اسکلروزیس مورد ارزیابی قرار گرفت. داده‌ها با استفاده از آزمون‌های آماری کای دو، t و t زوجی مورد تجزیه و تحلیل قرار گرفت. یافته‌ها: مشخصات دموگرافیک ابعاد جسمی کیفیت زندگی در بیماران گروه آزمون و شاهد قبل از مداخله اختلاف معنی داری نداشت. میانگین کیفیت زندگی در ابعاد جسمی بعد از مداخله در گروه آزمون (8/41±5/66) و در گروه شاهد (79/12±24/43) بود (001/0P
Prevalence of frailty among kidney transplant candidates and recipients in the United States: Estimates from a National Registry and Multicenter Cohort Study

Frailty, a measure of physiologic reserve, is associated with poor outcomes and mortality among kidney transplant (KT) candidates and recipients. There are no national estimates of frailty in this population, which may help patient counseling and resource allocation at transplant centers. We studied 4616 KT candidates and 1763 recipients in our multicenter prospective cohort of frailty from 2008‐2018 with Fried frailty measurements. Using Scientific Registry of Transplant Recipients (SRTR) data (KT candidates = 560 143 and recipients = 243 508), we projected the national prevalence of frailty (for KT candidates and recipients separately) using standardization through inverse probability weighting, accounting for candidate/recipient, donor, and transplant factors. In our multicenter cohort, 13.3% of KT candidates were frail at evaluation; 8.2% of LDKT recipients and 17.8% of DDKT recipients were frail at transplantation. Projected nationally, our modeling strategy estimated 91 738 KT candidates or 16.4% (95% confidence interval [CI] 14.4%‐18.4%) of all KT candidates during the study period were frail, and that 34 822 KT recipients or 14.3% (95% CI 12.3%‐16.3%) of all KT recipients were frail (LDKT = 8.2%; DDKT = 17.8%). Given the estimated national prevalence of frailty, transplant programs should consider assessing the condition during KT evaluation to improve patient counseling and resource allocation along with identification of recipients at risk for poor outcomes.
Maternal working conditions and low birth weight in Mexico City

The aim of this study was to examine the association between maternal working conditions and low birth weight in Mexico City. Interviews of 2623 female workers who gave birth in Mexico City hospitals during 1992 were analyzed. Information on main biologic and social factors associated to low birth weight was registered. Occupational stress was determined with the instrument designed by Karasek. Logistic regression models to evaluate the relationship between working conditions and low birth weight were used controlling by confounding variables. Low birth weight was more frequent in workers with working periods of more than 50 hours/week (OR = 1.6; 95% CI = 1.17-2.28) and with problems at work (OR = 1.5; 95% CI = 1.0-2.25). Lack of tangible social support was identified as a risk factor for low birth weight (OR = 1.7; 95% CI = 1.20-2.33). Preventive working measures such as changes in tasks shortening of working hours and leaves of absence due to illness did not show a beneficial effect on birth weight except for the maternity leave of absence. Mothers with no right to this had a 2.2 higher probability of giving birth to low-weight infants (95% CI = 1.66-2.93). These results emphasize the importance of identifying the occupational risk factors during pregnancy. (authors modified) (summaries in ENG SPA)
T HE F EELING OF D ISCRIMINATION AND IN F RANCE

aim to look at the of discrimination young people may feel due to their “foreign origin” and to assess its links on career paths, seven years after leaving in 1998. We used the method for clustering self-organising maps, supplemented by an econometric analysis to distinguish eight major classes of career pathways. The aim is to see how the fact of declaring having suffered discrimination may influence the professional situation of these young adults. By looking at both the time it takes to get a stable job and the quality of entry into the labour market, we were able to identify certain trends which differentiate the experiences of young persons of foreign origin suffering discrimination from those of other youths: the former need more time to get a steady job, while the quality of their work is lower and they may also suffer from both these disadvantages. Qualitative interviews were conducted with young people declaring discrimination in order to complement our statistical results. All the results show that the link between discrimination and career path is not so strong as one might think. (méthode de regroupement des cartes d’auto- organisation), complétée par une analyse économétrique. Nous cherchons à montrer en quoi le fait de se déclarer victime de discrimination peut avoir une influence sur la position professionnelle de ces jeunes adultes. En étudiant conjointement la durée d’accès à l’emploi stable et la qualité de l’insertion professionnelle, nous repérons certains liens qui différencient les trajectoires des jeunes d’origine étrangère victimes de discrimination de celles des autres jeunes : un retard dans l’accès à l’emploi stable, une moindre qualité de l’emploi ou encore un cumul des désavantages. Des entretiens qualitatifs menés auprès de certains jeunes se déclarant discriminés complètent ces résultats statistiques. Néanmoins, les résultats montrent que les liens entre les discriminations ressenties et les trajectoires ne sont pas aussi forts qu’on pourrait le penser en première analyse.
Progesterone receptor in the prostate: A potential suppressor for benign prostatic hyperplasia and prostate cancer

After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific consideration is given to recurrent alterations. A list of frequently reported genes is synthesized from 17 studies that have reported on methylation changes in malignant prostate tissue, and we chart the timing of those changes in the diseases history through amalgamation of several previously published
BTT-3307-review of lutropin alfa

Correspondence: Bernd Th Krause MvZ Uhlandstr. 19, 10623 Berlin, Germany Tel +49 3088716363 Fax +49 30887163659 email bthkrause@web.de Abstract: Hypogonadotropic hypogonadism is defined as a medical condition with low or undetectable gonadotropin secretion, associated with a complete arrest of follicular growth and very low estradiol. The main cause can be traced back to an irregular or absent hypothalamic GnRH secretion, whereas only a minority suffers from a pituitary disorder. The choice of treatment to reverse this situation is a pulsatile GnRH application or a direct ovarian stimulation using gonadotropin injections. The goal is to achieve a proper ovarian function in these cases for a short time to allow ovulation and chance of pregnancy. Since the pulsatile GnRH treatment lost its former importance, several gonadotropins are in use to stimulate follicular growth, such as urine-derived human menopausal gonadotropin, highly purified follicle stimulating hormone (FSH) or recombinant FSH, all with different success. The introduction of recombinant luteinizing hormone (LH) and FSH provided an opportunity to investigate the distinct influences of LH and FSH alone and in combination on follicular growth in monofollicular ovulation induction cycles, and additionally on oocyte maturation, fertilization competence of the oocyte and embryo quality in downregulated IVF patients. Whereas FSH was known to be indispensable for normal follicular growth, the role of LH remained questionable. Downregulated IVF patients with this short-term gonadotropin depletion displayed no advance in stimulation success with the use of recombinant LH. Patients with hypogonadotropic hypogonadism undergoing monofollicular stimulation for ovulation induction showed clearly a specific role and need for both hormones in normal follicular growth. Therefore, a combined stimulation with FSH and LH seems to be the best treatment choice. In the first half of the stimulation cycle the FSH dosage should exceed that of LH by 2:1, with an inverse ratio for the second half.
Evaluating Strategies for the Primary Prevention of Cardiovascular Disease

In this thesis we aimed at contributing to the evidence on the optimal strategy for the primary prevention of cardiovascular disease in modern Western populations using a risk based approach. More specifically, we constructed models by abstracting and deducing data from the cumulative work of others. If one would characterize this thesis in an overly simplistic approach, one could argue that we have merely aggregated and synthesized data that has already been produced through the extensive efforts of others. In fact, that is exactly what we did. Nevertheless, data synthesis is a far more daunting task than it may seem. Besides summarizing the main findings in this thesis, this chapter will be used to elaborate on the complexity of data synthesis and how this process has an important place in assessing the optimal strategy for the primary prevention of cardiovascular disease. The limitations and challenges of this approach will also be discussed.
Cellular Factors Involved in Transcriptome Dynamics in Early Zebrafish Embryogenesis

At gastrulation in the zebrafish embryogenesis, the embryonic genome is switched on to produce transcripts that are used for the maintenance and development of the embryo. In a previous study from late blastula to mid gastrula on the transcriptomes of 179 individual embryos, we capture the transcriptome dynamics via ten gene-expression types. Here we study the factors that regulate these transcriptome dynamics by in extensive silico analyses and two small-RNA sequencing experiments. We analyzed mechanisms that would make it possible for the embryo to achieve the tight regulation of gene expression that was observed, not only during development, but also when individual embryos were compared. We found that many of the gene-expression regulatory factors that are available to the embryo are operational in the different gene-expression types and act concurrently with not one mechanism prevailing in this developmental phase. We also saw that at least one of the regulatory mechanisms, the expression of members of the miRNA-430 family again is very tightly regulated, both during development as well as when miRNA expression from individual embryos is compared.
Radiological Features of Human Infection with Avian Influenza A H7N9 Virus: A Report of Three Cases

Abstract Human infection with avian influenza A H7N9 virus has emerged in China with high morbidity rates. Patients usually present with severe and rapidly progressive pneumonia. Therefore, radiological findings are important to diagnose and evaluate disease severity. The clinical characteristics of three new cases of H7N9 virus infection were analyzed, especially the radiological findings, and previously published studies regarding H7N9 virus infection were summarized. Ground-glass opacification and areas of consolidation were the most common image features. Although drug resistance has been found in some H7N9 viruses, oseltamivir administration is still recommended as soon as possible. Moreover, timely epidemiological surveillance is needed, and a new vaccine is expected for the management of avian influenza.
Precision measurement of the structure of the CMS inner tracking system using nuclear interactions

The structure of the CMS inner tracking system has been studied using nuclear interactions of hadrons striking its material. Data from proton-proton collisions at a center-of-mass energy of 13 TeV recorded in 2015 at the LHC are used to reconstruct millions of secondary vertices from these nuclear interactions. Precise positions of the beam pipe and the inner tracking system elements, such as the pixel detector support tube, and barrel pixel detector inner shield and support rails, are determined using these vertices. These measurements are important for detector simulations, detector upgrades, and to identify any changes in the positions of inactive elements.
A study into the relationship between dental development and cervical vertebral maturation in UK subjects

Aim: To examine relationships between dental and skeletal maturity in White British and Asian UK subjects. Methods: Ninety subjects per ethnic group, with digital panoramic and lateral cephalometric radiographs, were selected from the records of Birmingham Dental Hospital. Dental maturity was assessed from the development stage of the left mandibular canine, first and second premolar, and second molar using the Demirjian Index (DI). Skeletal maturity was determined from cervical vertebral maturation (CVM) stage using the method of Baccetti. Spearman rank-order correlation coefficients were calculated to measure the association between DI and CVM. Results: Females reached each CVM stage at an earlier age than males. There was no statistically significant difference in the mean age of White British and Asian subjects at each CVM stage. The mandibular canine had the highest correlation with CVM stage in White British males (r = 0.568). The mandibular second molar demonstrated the highest correlation to CVM stage in White British females and in Asian males and females (r = 0.533; r = 0.752; r = 0.569 respectively). Conclusion: Moderate statistically significant correlations were observed between DI and CVM stages, suggesting that dental development stage can be considered as a method for determining skeletal maturity in UK subjects during orthodontic treatment planning.
Does Exercise Protect From Coronary Artery Disease?1

: New studies support a lifestyle of regular physical activity. Regular physical activity most likely decreases one's risk for coronary heart disease and helps to decrease other risk factors. The inclusion of regular moderate exercise in one's life-style makes good sense for many reasons. It can improve the quality of life by avoiding illness and the quality is definitely improved in those in whom physical performance is important. Some say that physical exercise will increase the quantity of life but the extra years gained are spent exercising.