Miracle-dz/UniFAR-FTUs huggingface dataset:
Wirkfaktoren in der Gruppentherapie: Fragebogen zur Messung der therapeutischen Perspektive

Zusammenfassung In der bisherigen Forschung hat sich Gruppentherapie als ökonomisch und effektiv erwiesen. Es existieren bislang wenige Instrumente, um die Wirkfaktoren des therapeutischen Prozesses in der Gruppentherapie empirisch zu messen. Der Fragebogen zum Erleben von therapeutischen Prozessen in der Gruppe für Therapeutinnen (FEPiG-T) zur Erfassung von allgemeinen Wirkfaktoren aus der therapeutischen Perspektive wurde in dieser Studie basierend auf Konzeptualisierungen von Bordin, Yalom und Grawe entwickelt und validiert. Die FEPiG-T Subskalen zeigten gute interne Konsistenzen und waren im Sinne der konvergenten Validität mit etablierten Prozessmaßen assoziiert. Es zeigten sich Zusammenhänge der Wirkfaktoren zu Beginn der Therapie mit der Reduktion interpersonaler Probleme über die Zeit. Die Wirkfaktoren über den Therapieverlauf waren trendmäßig mit der Symptomverbesserung korreliert. In der Forschung könnte der korrespondierende Fragebogen zur bereits etablierten Version für Patientinnen eine detaillierte Untersuchung der Perspektiven im Therapieverlauf ermöglichen. In der Praxis würde das Instrument eine Selbsteinschätzung für Therapeutinnen und ein Feedback darüber bieten, ob gerade Differenzen über die Wahrnehmung der aktuellen Gruppenwirkfaktoren bestehen.
Can we predict the success of prostatic surgery for male lower urinary tract symptoms: ICI‐RS 2018?

Male lower urinary tract symptoms (LUTS) are common and bothersome symptoms in the aging population, of which the etiology is multifactorial. Prostatic surgery may be considered to alleviate some of these LUTS, especially in patients in which benign prostatic obstruction is believed to be the underlying cause.
Trends in Prescription Analgesic Use Among Adults With Musculoskeletal Conditions in the United States, 1999-2016

Key Points Question How did prescription analgesic use change among US adults with a potential need for pain management for musculoskeletal conditions from 1999 to 2016? Findings In this repeated cross-sectional analysis of nationally representative data from 7256 adults, opioid and nonopioid analgesic use exhibited reciprocal trends, with decreases in nonopioid analgesic use offset by increases in opioid use. Meaning Substitution of opioids for nonopioid analgesics may have occurred as evidence emerged on the cardiovascular risks associated with nonopioid analgesics, and despite recent decreases, opioid use remained more prevalent in 2016 than in 1999.
Patient Reported Efficacy of Botulinum Toxin Type A in the Treatment of Chronic Migraine Headaches

Objective: To assess patient reported efficacy of Botulinum toxin type-A for the prophylaxis of migraine headaches in patients with frequent migraine headaches prior to initiation of treatment with Botulinum toxin type-A compared to post treatment. Questions addressed include is there a difference in frequency of migraine headaches following treatment with Botulinum toxin type-A, is there a difference in cost of conventional treatment versus Botulinum toxin type-A and is there a difference in quality of life. Research Plan: Questions addressed patient status prior to the initiation of treatment as well as post treatment. Patient quality of life change, duration and frequency headache improvement are the primary focus. Other considerations included the cost difference between the previous use of other treatment and the periodic treatment with Botulinum toxin type-A. Methodology: A Cross Sectional study utilizing a questionnaire consisting of a modified Migraine Disability Assessment (MIDAS) questionnaire will be given to patients who had received more than one series of injections. Patients who reported chronic migraine headaches and were refractory to previous treatment methods were screened and placed
The interconnection between cytokeratin and cell membrane-bound β-catenin in Sertoli cells derived from juvenile Xenopus tropicalis testes

ABSTRACT Sertoli cells (SCs) play a central role in the determination of male sex during embryogenesis and spermatogenesis in adulthood. Failure in SC development is responsible for male sterility and testicular cancer. Before the onset of puberty, SCs are immature and differ considerably from mature cells in post-pubertal individuals regarding their morphology and biochemical activity. The major intermediate filament (IF) in mature SCs is vimentin, anchoring germ cells to the seminiferous epithelium. The collapse of vimentin has resulted in the disintegration of seminiferous epithelium and subsequent germ cell apoptosis. However, another IF, cytokeratin (CK) is observed only transiently in immature SCs in many species. Nevertheless, its function in SC differentiation is poorly understood. We examined the interconnection between CK and cell junctions using membrane β-catenin as a marker during testicular development in the Xenopus tropicalis model. Immunohistochemistry on juvenile (5 months old) testes revealed co-expression of CK, membrane β-catenin and E-cadherin. Adult (3-year-old males) samples confirmed only E-cadherin expression; CK and β-catenin were lost. To study the interconnection between CK and β-catenin-based cell junctions, the culture of immature SCs (here called XtiSCs) was employed. Suppression of CK by acrylamide in XtiSCs led to breakdown of membrane-bound β-catenin but not F-actin and β-tubulin or cell-adhesion proteins (focal adhesion kinase and integrin β1). In contrast to the obvious dependence of membrane β-catenin on CK stability, the detachment of β-catenin from the plasma membrane via uncoupling of cadherins by Ca2+ chelator EGTA had no effect on CK integrity. Interestingly, CHIR99021, a GSK3 inhibitor, also suppressed the CK network, resulting in the inhibition of XtiSCs cell-to-cell contacts and testicular development in juvenile frogs. This study suggests a novel role of CK in the retention of β-catenin-based junctions in immature SCs, and thus provides structural support for seminiferous tubule formation and germ cell development. Summary: Cytokeratin (CK) and β-catenin are expressed in juvenile testicles and cultivated Xenopus tropicalis immature Sertoli cells (SC). Acrylamide and CHIR99021 disrupted the CK network, immature SC connections and testes development.
Fiber-Based Composite Meshes with Controlled Mechanical and Wetting Properties for Water Harvesting.

Water is the basis of life in the world. Unfortunately, resources are shrinking at an alarming rate. The lack of access to water is still the biggest problem in the modern world. The key to solving it is to find new unconventional ways to obtain water from alternative sources. Fog collectors are becoming an increasingly important way of water harvesting as there are places in the world where fog is the only source of water. Our aim is to apply electrospun fiber technology, due to its high surface area, to increase fog collection efficiency. Therefore, composites consisting of hydrophobic and hydrophilic fibers were successfully fabricated using a two-nozzle electrospinning set up. This design enables the realization of optimal meshes for harvesting water from fog. In our studies we focused on combining hydrophobic, polystyrene (PS) and hydrophilic, polyamide 6 (PA6) surface properties in the produced meshes, without any chemical modifications, based on new hierarchical composites for collecting water. This combination of hydrophobic and hydrophilic material cause water to condense on the hydrophobic microfibers and to run down on the hydrophilic nanofibers. By adjusting the fraction of PA6 nanofibers we were able to tune the mechanical properties of PS meshes and importantly increase the efficiency in collecting water. We combined a few characterization methods together with novel image processing protocols for the analysis of fiber fractions in the constructed meshes. The obtained results show a new single-step method to produce meshes with enhanced mechanical properties and water collecting abilities that can be applied in existing Fog Water Collectors. This is a new promising design for fog collectors with nano- and macro- fibers which are able to efficiently harvest water, showing a great application in comparison to commercially available standard meshes.
Real-world risk exposure in older drivers with cognitive and visual dysfunction

Abstract Objective: This study addresses the need to measure and monitor objective, real-world driver safety behavior in at-risk drivers with age-related dysfunction. Older drivers are at risk for age-related cognitive and visual dysfunction, which may reduce mobility and increase errors that lead to crashes. Understanding patterns of real-world behavior, exposure, and cognitive–perceptual processes underlying risk in environmental context and in older drivers requires new approaches. Methods: We assessed patterns of objective, real-world driver risk exposure and vehicle control related to steering, braking, and accelerating in older adults with a range of cognitive and visual functional abilities. Real-world driver behavior was collected from passive-monitoring systems installed in 77 drivers’ vehicles and analyzed across 242,153 km (150,467 miles) driven. Driver behavior was assessed cross-sectionally in relationship to driver functional abilities and safety-critical environmental contexts (roadway type and visibility condition). Results: Results suggest that cognitive dysfunction impairs vehicle control across wide-ranging environments. Drivers with greater cognitive dysfunction showed more erratic braking and accelerating during daytime commercial and interstate driving. Drivers with less cognitive dysfunction showed more erratic braking and accelerating on residential roadways regardless of visibility condition. Greater cognitive dysfunction predicted more erratic steering on commercial and interstate roadways and less erratic steering on residential roadways. Greater visual dysfunction impaired braking and accelerating during nighttime and interstate driving, but not on residential or commercial roadways. Steering behavior was unaffected by visual abilities. Drivers with greater cognitive dysfunction did not appear to reduce driving frequency in higher-risk environments. Visually impaired drivers drove more on residential roadways and less on commercial roadways, but did not reduce driving on interstates, where they showed the greatest risk per mile driven. Conclusions: Results successfully mapped driver cognitive and visual profiles onto contemporaneous, real-world behavior and risk loci. Results link age-related dysfunction to real-world vehicle control and show that drivers may not sufficiently reduce exposure to higher-risk driving environments. Employing naturalistic observation to monitor and measure patterns of driver behavior can inform methods for early detection of age-related risk, fitness-to-drive assessments, and interventions to preserve safety, mobility, and quality of life in aging or other at-risk populations.
Diversity of Plants Species Abundantly Consumed In Traditional Practice of Siamese Community of Kelantan, Malaysia

Siamese community in Kelantan are more health conscious by taking plants with medicinal value as daily dietary intake but type of plants and its traditional use yet to be explore and recorded. The objective is to identify and document plants and plant parts those are being consumed and the traditional uses. Plants that are being consumed by Siamese community in three main localities were recorded by a verbal interview with old folks of the village. Plants were collected with the guide of the old folks for identification. From the identified names, further information was collected through literature reviewed on their recorded medicinal values. A total of 20 plants were collected, identified and reported. The plants belong to 16 families. The list of plants recorded serves as a datasheet for the study of plants with medicinal value consumed by Siamese community of Kelantan.
Cartilaginous Metaplasia Involving the Atrioventricular Node and Bundle of His Contributing to Sudden Early Neonatal Death

Cartilaginous metaplasia involving the atrioventricular (AV) node is an uncommon entity that may cause sudden cardiac death secondary to dysrhythmias. We report 2 autopsy cases of full-term male newborns: 1 stillborn and 1 live-born, with antemortem bradycardia who died in the peripartum period. An examination of the cardiac conduction system in both cases demonstrated extensive cartilaginous metaplasia of the central fibrous body and involvement of the AV node and bundle of His. The cases highlight the recognition of cardiac conduction system anomalies as a cause of sudden perinatal death. In cases of perinatal death with preceding arrhythmia, postmortem sections of the cardiac conduction system are recommended to examine for cardiac conduction system anomaly.
Reduced Enhancement of Memory for Faces Encoded by Semantic and Socioemotional Processes in Patients with Parkinson’s Disease

Abstract Objectives: Patients with Parkinson’s disease (PD) exhibit impaired semantic and socioemotional processes, which are thought to be related to dysfunctions in the fronto-striatal circuit. However, little is known about how the memory enhancement by these processes was reduced in PD. The present study investigated this issue. Methods: The retrieval performance of face memories encoded by semantic and socioemotional processes was compared between 24 PD patients and 24 age-matched healthy controls (HC). During encoding, participants were presented with unfamiliar faces and made judgment about them in three encoding conditions of semantic judgment (Semantics), attractiveness judgment (Attractiveness), and form judgment (Form). In Semantics, participants rated to what degree each face looked like an office worker, whereas in Attractiveness, participants rated how attractive each face was. The Form condition as a control required participants to judge the shape of each face. During retrieval after encoding, participants made old or new judgment for target and distracter faces. Results: In HC, the retrieval of faces encoded by Semantics and Attractiveness was significantly more accurate than that encoded by Form, whereas this memory enhancement was not identified in PD. In addition, individual scores in frontal lobe function and long-term memory correlated with the retrieval performance of memories encoded in Semantics and Attractiveness but not Form. Conclusions: These findings suggest that the processing of semantic and socioemotional signals conveyed from faces could be impaired in PD and that the impairment of these processes could decrease the enhancement of face memories by semantic and socioemotional elaborations.
Assessment of Cognitive-Driven Performance-Based Activities of Daily Living Dysfunction in Parkinson’s Disease

Abstract Objectives: Parkinson’s disease (PD) patients with mild cognitive impairment (PD-MCI) have an increased risk of developing dementia (PDD). As activities of daily living (ADL) impairment is mandatory for the diagnosis of PDD, assessing early signs of instrumental ADL (iADL) dysfunction, especially in PD-MCI, is essential. In PD, self- and caregiver-reported iADL performance is often confounded by motor dysfunction and mood. Objective and time-efficient performance-based measurements are needed to screen for cognitive-related iADL dysfunction. We evaluated the Erlangen Test of Activities of Daily Living in Mild Dementia and Mild Cognitive Impairment (ETAM) in PD and determined its value for characterizing a subgroup of PD-MCI patients with mild performance-based iADL impairment. Methods: Twenty-one cognitively normal PD patients (PD-NC), 24 PD-MCI patients, and 18 healthy controls (HC) were analyzed. Assessments included the ETAM, a comprehensive neuropsychological test battery, iADL, mood, and motor measurements. Results: PD-MCI patients scored significantly lower on the ETAM total score compared to PD-NC patients (p = .002), whereas HC and PD-NC patients did not statistically differ. No HC scored lower than 27 points (diagnostic cutoff for mild iADL impairment); only PD-MCI patients scored below this cutoff (29.2%) suggesting the ETAM is able to characterize a PD-MCI subgroup with early iADL impairment. PD-MCI patients below the cutoff were more impaired in the attention domain (p = .04). Conclusions: The ETAM is a potentially valuable clinical assessment, able to detect first signs of iADL dysfunction in PD-MCI. Further studies in larger cohorts are needed to evaluate the prognostic ability for predicting PDD.
Tubulopapillary Carcinoma: An Aggressive Variant of Invasive Breast Carcinoma With a Micropapillary DCIS-Like Morphology

Tubulopapillary carcinoma is a recently described variant of breast carcinoma characterized by a proliferation of elongated and anastomosing tubular glands exhibiting intraluminal micropapillary and sometimes papillary epithelial projections. We have recently encountered a patient with invasive breast carcinoma displaying a prominent tubulopapillary component. The histomorphology in our case had an uncanny resemblance to micropapillary ductal carcinoma in situ, but the invasive nature of the glands was confirmed not only by the lack of myoepithelial cells but also by the presence of identical metastatic foci within ipsilateral axillary lymph nodes. This case was made all the more intricate by the simultaneous presence of invasive micropapillary carcinoma in the opposite breast and a carcinosarcoma of the uterus with a serous papillary carcinoma component. As noted in the only prior report on tubulopapillary carcinoma of the breast, our case confirms the aggressive nature of this form of invasive carcinoma, the histological features of which appear to be easily identifiable and reproducible.
Graphene oxide-based experimental silane primers enhance shear bond strength between resin composite and zirconia.

Despite various mechanical and chemical surface-pretreatment methods, long-term bonding of resin composite to dental zirconia (ZrO2 ) remains a major concern. In this study, graphene oxide (GO) sheets were infused into two commercially available primers and the enclosed mould shear bond strength (EM-SBS) of resin composite to ZrO2 was evaluated. Twelve fully sintered ZrO2 blanks were pretreated and randomly allocated to four groups according to the primers used: RelyX (RX); GO blended RelyX (RXGO); Monobond-S (MB); and GO blended Monobond-S (MBGO). The resin composite stubs were bonded onto the pretreated ZrO2 surfaces and analysed at baseline and after storage in distilled water for 2 and 4 months. The experimental primers blended with GO sheets influenced the surface morphology, visualized as increased surface roughness, and slightly increased the water contact angle measurements. Moreover, the infusion of primers with GO increased the mass fraction (wt%) of carbon and oxygen. The highest EM-SBS values were found for RXGO, with mean (SD) EM-SBS values of 26.4 (3.7) MPa and 21.5 (5.1) MPa after 2 and 4 months of storage, respectively. Infusion of silane primers with nanometre- to micrometre-size GO sheets enhanced the SBS between resin composite and ZrO2 .
Pharmacokinetics, Pharmacodynamics, and Safety of a Single Escalating Dose and Repeated Doses of Rasagiline Transdermal Patch in Healthy Chinese Subjects

A rasagiline transdermal patch can be used to offer continuous rasagiline to patients with Parkinson's disease who cannot take their usual oral medications. This was the first study to investigate the pharmacokinetics, pharmacodynamics, and safety of the rasagiline transdermal patch in healthy Chinese subjects. Thirty subjects were randomized to 3 groups with 10 subjects in each group. The 10 subjects of group 1 received a single 1‐mg dose of rasagiline as a tablet; the 20 subjects of groups 2 and 3 received a single transdermal patch (48‐hour patch‐on period) containing 1.25 mg and 2.5 mg rasagiline, respectively. After a 2‐week washout period, the subjects of group 1 were assigned to receive 1 mg of rasagiline tablets every 24 hours for 7 days, and the subjects of group 2 were assigned to receive 1.25‐mg rasagiline transdermal patches (48‐hour patch‐on period) every 72 hours for 5 time periods. The absorption of rasagiline from the transdermal patch was significantly improved, although the peak plasma concentration was obviously reduced. There was slight accumulation of rasagiline dose after multiple administrations. Inhibition of platelet monoamine oxidase‐B (MAO‐B) activity was dose dependent. The 80% inhibition maintained for at least 48 hours after multiple‐dose administration of 1 mg tablets, and for 72 hours after multiple‐dose administration of 1.25 mg/48 h patch. Compared with rasagiline tablets, the transdermal patch had a prolonged duration of 80% inhibition and increased maximal inhibition of MAO‐B activity. These characteristics permitted an interval of 3 days of dosing, which was convenient for patients to use.
The effect of single and repeated tDCS sessions on motor symptoms in Parkinson's disease: a systematic review.

OBJECTIVES to update understanding of the effectiveness of transcranial direct current stimulation (tDCS) on motor dysfunction in Parkinson's disease, since the last review was published in 2016. METHODS in order to identify suitable publications for inclusion, an online search of the Pubmed, Scopus and Cochrane databases was carried out. Searches of relevant full-text articles were performed through specific keywords. The final database check was performed in July 2019. Papers were restricted to studies investigating motor rehabilitative effects of tDCS in adult patients with Parkinson's disease. Studies involving either single or repeated tDCS sessions with a sham or controlled trial type design (which incorporated outcomes on motor performance measures) were considered. As studies varied widely in terms of methodology, a qualitative analysis of the selected studies was performed using the Newcastle-Ottawa Quality Assessment Scale or the Delphi list (depending on the study design). RESULTS twenty-nine studies were retained in this systematic review. Of the studies included, fifteen involved single tDCS session (patients = 256) and fourteen involved repeated tDCS sessions (patients = 294). Eight investigations of single tDCS and ten investigations of repeated tDCS demonstrated significant results. Studies involving multi- target stimulation demonstrated significant improvements on mobility (p=0.006), balance (by 50.9%), gait velocity (by 29%), fall reduction (p0.05) compared to mono-target stimulations. CONCLUSIONS despite increasing evidence that tDCS may improve motor symptoms, the results showed that fully optimized tDCS protocols are not yet established.