Miracle-dz/UniFAR-FTUs huggingface dataset:
Detección de errores de medicación mediante un programa de seguimiento y minimización en pacientes ambulatorios de Colombia, 2018-2019

Introducción El uso de medicamentos puede conllevar errores de medicación que desemboquen en la hospitalización del paciente, el aumento de los costos relacionados con la atención e, incluso, la muerte. Objetivos Determinar la prevalencia de errores de medicación notificados en un sistema de información de farmacovigilancia en Colombia entre el 2018 y el 2019. Materiales y métodos Se hizo un estudio observacional a partir del registro de errores de medicación de un sistema de farmacovigilancia que cubre a 8,5 millones de pacientes ambulatorios afiliados al sistema de salud de Colombia. Los errores se categorizaron en ocho grupos de la A (situaciones potenciales de error) hasta la I (error que pudo llevar a la muerte). Se hizo el análisis descriptivo y se estableció la prevalencia de los errores de medicación. Resultados Durante los años 2018 y 2019, se reportaron 29.538 errores de medicación en pacientes ambulatorios, con una prevalencia general de 1,93 por cada 10.000 medicamentos dispensados. En el 0,02% (n=6) de los casos, se presentaron errores que llegaron a afectar a los pacientes y causaron daño (tipos E, F e I). La mayoría de los errores se asoció con la dispensación (n=20.636; 69,9%) y la posible causa más común fue la falta de concentración en el momento de dispensar los medicamentos (n=9.185; 31,1%). Los grupos farmacológicos más implicados en errores de medicación fueron los antidiabéticos (8,0%), los inhibidores del sistema renina-angiotensina (7,6%) y los analgésicos (6,0%). Conclusiones Los errores de medicación son relativamente poco frecuentes y con mayor frecuencia se catalogan como circunstancias o eventos capaces de generar un error de tipo A. Muy pocas veces, pueden causarle daño al paciente, incluso, hasta la muerte.
Integrating psychology into paediatric healthcare: A UK perspective

The paediatric psychologist role has become increasingly embedded within healthcare teams with increasing recognition of the importance of integrating emotional health in physical health contexts. Ward et al.’s excellent article in the current issue provides a useful description and evaluation of the ways that psychological practices can become embedded within paediatric healthcare teams in the US (Ward et al., 2021). Several factors have influenced the contexts for change for Paediatric Psychology in the United Kingdom (UK) over the past two decades which are both similar and dissimilar to those described in Ward et al. Contexts are dynamic and within them sit the environmental mechanisms that can facilitate, block and shape the implementation of novel healthcare practices and interventions (May et al., 2016). Describing implementation experiences within different contexts brings our shared endeavours to life and help take thinking and practices forward. One way to define the multiple contexts in which healthcare practices occur, uses a concentric circle model (Damschroder et al., 2009). In relation to the individual there is the ‘outer setting’ of political and economic factors, and an ‘inner setting’ provided by the professional and organisational cultures and the senior leadership approach, which shape the building of vision and strategy. The next concentric circle can be seen as the relational context, shaped by working relationships and practices between healthcare professionals and teams, and other characteristics of the adopters. The nature of the innovation or practice, and the needs and characteristics of the end users (e.g. the patients) also influence how change moves forward and the outcomes of that change (Greenhalgh et al., 2005; Nilsen, 2015). Contexts are diffuse and overlapping and can be conceptualised in other ways (May et al., 2016) but this understanding is useful for the purposes of this commentary on the development of Paediatric Psychology practice in the UK. The British Psychological Society (BPS) is a representative body for psychologists and psychology in the UK. Responding as part of the National Institute for Mental Health in England (NIMHE) New Ways of Working for Applied Psychology initiative in 2007, it published: New Ways of Working for Applied Psychologists in Health and Social Care – Working Psychologically in Teams
The effects of scientific messages and narratives about vaccination

A fundamental challenge complicates news decisions about covering vaccine side effects: although serious vaccine side effects are rare, less severe ones do occur occasionally. The study was designed to test whether a side effect message could induce vaccine hesitancy and whether that could be countered by pro-vaccine messages about vaccine safety. A large (N = 2,345), nationally representative experiment was conducted by randomly exposing participants to one of six videos about the measles, mumps, and rubella (MMR) vaccine edited from news programs produced during the 2019 measles outbreak in the United States. The design was a 2x3 factorial crossing the presence or absence of a hesitancy-inducing narrative message with a pro-vaccine science-supporting message (i.e., no message, science-supporting expert message, or pro-vaccine narrative message), leading to a total of six conditions. A general linear model was used to assess the effects of these videos on respondents’ (1) vaccine risk perceptions, (2) policy views on vaccination, (3) willingness to encourage others to vaccinate their children, and (4) intention to send a pro-vaccine letter to their state representative. Findings indicated that the science-supporting expert message about vaccine safety led to higher pro-vaccine evaluations relative to other conditions [e.g., b = -0.17, p < . 001, a reduction in vaccine risk perceptions of 0.17 as compared to the control]. There was also suggestive evidence that the hesitancy-inducing narrative may limit the effectiveness of a science-supporting expert message, although this finding was not consistent across different outcomes. When shown alone the hesitancy-inducing narrative did not shift views and intentions, but more research is needed to ascertain whether exposure to such messages can undercut the pro-vaccine influence of science-supporting (expert) ones. All in all, however, it is clear that science-supporting messages are effective and therefore worthwhile in combating vaccine misinformation.
Feasibility of an online platform delivery of pulmonary rehabilitation for individuals with chronic respiratory disease

Introduction SARS-CoV-2 has restricted access to face-to-face delivery of pulmonary rehabilitation (PR). Evidence suggests that telehealth-PR is non-inferior to outpatient PR. However, it is unknown whether patients who have been referred to face-to-face programmes can feasibly complete an online-PR programme. Methods This service evaluation used a mixed-methods approach to investigate a rapid PR service remodelling using the University of Gloucestershire eLearn Moodle platform. Quantitative baseline demographic and PR outcome data were collected from online-PR participants, and semistructured interviews were completed with PR staff and participants. Results Twenty-five individuals were eligible from a PR waiting list. Thirteen declined participation and 14 completed PR. Significant pre-post online PR improvements were achieved in 1 min sit-to-stand (CI 2.1 to 9 (p=0.004)), Generalised Anxiety Disorder (CI −0.3 to −2.6 (p=0.023)), Primary Health Questionnaire-9 (CI −0.3 to −5.1 (p=0.029)), Chronic Respiratory Questionnaire dyspnoea (CI 0.5 to 1.3 (p=0.001)), fatigue (CI 0.7 to 2 (p=0.0004)), emotion (CI 0.7 to 1.7 (p=0.0002)), mastery (CI 0.4 to 1.3 (p=0.001)). Interviews indicated that patient PR inclusion was made possible with digital support and a PR introduction session improved participant engagement and safety. Incremental progression of exercise was perceived as more successful online compared with face-to-face PR. However, perceptions were that education sessions were less successful. Online-PR required significant staff time resource. Discussion Online-PR improves patient outcomes and is feasible and acceptable for individuals referred for face-to-face PR in the context of a requirement for social distancing. Face-to-face programmes can be adapted in a rapid fashion with both staff and participants perceiving benefit. Future pragmatic trials are now warranted comparing online-PR including remote assessments to centre-based PR with suitably matched outcomes, and patient and staff perceptions sought regarding barriers and facilitators of online delivery.
Chemical induction of neurogenic properties in mammalian Müller glia

Müller glia (MG), cells that maintain homeostasis in the retina, are dormant stem cells that can regenerate neurons upon injury. However, the regenerative property of MG, which is reproducibly displayed in the lower vertebrates, is not readily observed in the mammals even upon forced expression of regulatory genes or exposure to growth factors. Here, we demonstrate a reproducible unmasking of the neurogenic properties of enriched rodent MG by serial exposure to different combinations of small molecules. The enriched MG, in response to changing culture conditions, silenced glia‐specific genes and acquired transcriptional signature of neurons, accompanied by upregulation of genes known to regulate neuronal potential of MG. The MG‐derived neurons expressed immunoreactivities corresponding to neuronal proteins and displayed electrophysiological features of immature neurons. Our study presents a proof of principle of pharmacological activation of neurogenic properties of mammalian MG, which may be utilized for therapeutic regeneration.
Effectiveness and safety of massage in the treatment of obesity

Abstract Background: Obesity has become one of the largest chronic diseases in the world. It is a chronic metabolic disease caused by various factors. In recent years, massage has been used more and more widely in the treatment of obesity diseases. However, the effectiveness and safety of massage in the treatment of adult obesity are still unclear. The purpose of this study is to evaluate the effectiveness and safety of massage in the treatment of adult obesity. Methods: We will conduct a comprehensive review in Medline, PubMed, Cochrane System Evaluation Database, embbase, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wang Fang Database, Chinese Science Journal Database. There is no language restriction for the literature search from its establishment to February 2021. In addition, we will manually search for references to unpublished studies and originally included articles. Reviewers will identify the research, extract the data, and independently assess the quality. Results of interest include: total effective rate; total nasal symptom score; rhinitis quality-of-life questionnaire; visual analog scale; laboratory test indicators: IgE, IL6, IL10, or TNF-α levels; recurrence rate; adverse events. Randomized clinical trials will be collected, the Cochrane bias risk assessment tool will be used to assess methodological quality, and recommendations, evaluation, development, and evaluation methods will be used to assess the level of evidence. The meta-analysis will be performed using RevMan 5.4. 0 software. A heterogeneity test will be conducted between studies, and P <. 1 and I2> 50% are the thresholds for testing. According to the degree of heterogeneity, we will use a fixed effects model or a random effects model. Results: The results of this study will provide sufficient evidence to judge whether massage is an effective and safe treatment for adult obesity. Conclusions: This study will provide evidence to determine whether massage is an effective intervention for Adult obesity. The research results will also be published in a peer-reviewed journal. INPLASY registration number: INPLASY 202120061
Ancestry and admixture of a southernmost Chilean population: The reflection of a migratory history

Punta Arenas is a Chilean city situated on ancestral Aönikenk territory. The city was founded by 19th‐ and 20th‐century colonists from Chile (Chiloé) and Europe (Croatia). This work uses uniparental and ancestry‐informative markers (AIMs) to explore the effects of historic migratory and admixture patterns on the current genetic composition of Punta Arenas.
Self-reported strategy generation and implementation in the multiple errands test: A qualitative description

ABSTRACT The Multiple Errands Test (MET) is a naturalistic assessment of executive function. Strategy use during the MET can provide useful information for the development of a cognitive profile and intervention plan in patients with brain injury. However, while observed external strategy use in the MET is well-documented, information about internal strategy use and reference data with healthy controls is limited. Contextual influences on strategy selection in this real-world assessment are also not well understood. This qualitative descriptive study explored the internal and external strategies used during MET performance by cognitively intact adults. Strategies were categorized as planning, checking, and problem solving. When planning, participants simplified and familiarized themselves with MET requirements before developing an action plan. They checked their performance by asking for help and using cues in the physical environment. When problems arose, these were solved through self-talk, comparing alternatives, applying context and modifying their plan. Results highlighted that individuals employ both visible and hidden strategies during the MET. This suggests that reflective discussions with patients following cognitive task engagement may be important, to uncover and understand strategy use, both to inform analysis of performance and guide strategy training.
Kinetics of radium-223 and its effects on survival, proliferation and DNA damage in lymph-node and bone metastatic prostate cancer cell lines

Abstract Background Metastatic castration-resistant prostate cancer (mCRPC) is associated with a very unfavorable prognosis. At this advanced stage of the disease, there are several therapeutic strategies approved in recent times, being one of them Radium-223 dichloride (Radium-223). However, its mechanisms of action and the process that conducts to cell death are not fully understood. Given this, our main goal is to characterize the radiobiological effects induced by Radium-223 and to evaluate its kinetics on metastatic Prostate Cancer (mPCa) cells. Materials and Methods In vitro studies were conducted using two mPCa cell lines, the LNCaP and PC3, the first being derived from lymph node metastasis and the second from bone metastasis. Kinetic studies were conducted to access the capacity of these cell lines to uptake, retain and internalize the Radium-223. For the assessment of radiobiological effects, cells were first exposed to different doses of Radium-223 and the clonogenic assay was done to evaluate cell survival and to determine lethal doses (LD50). Then, the effects were also evaluated in terms of proliferation, oxidative stress, morphological changes and cell damage. Results Radium-223 is uptaken by mPCa cells and reaches the nucleus, where it is retained over time. Irradiation decreases cell survival and proliferation, with LNCaP cells (LD50 = 1.73mGy) being more radiosensitive than PC3 cells (LD50 = 4.20mGy). Irradiated cells showed morphological changes usually associated with apoptosis and a dose-dependent increase in DNA damage. Moreover, activation of cell cycle checkpoints occurs through ATM/CHK2 pathway, which is involved in cell cycle arrest and cell death. Conclusions The cytotoxic and anti-proliferative effects on both cell lines showed that Radium-223 can decrease the aggressiveness of tumor cells by decreasing the cell survival and proliferation and, also, by increasing the DNA damage. The similar results observed in both cell lines indicated that Radium-223 may have the potential to be used as a therapeutic option also for mCRPC patients with lymph node metastasis. The activation of DNA Damage Response pathways allows the possibility to understand the importance of these checkpoints as targets for new combined therapies.
Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel

Cardiac disease is now the leading cause of death in Duchenne muscular dystrophy (DMD). Clinical evaluations over time have demonstrated asymptomatic cardiac troponin elevations and acute elevations are associated with symptoms and cardiac dysfunction in DMD. Clinicians require a better understanding of the relationship of symptoms, troponin levels and progression of cardiac disease in DMD. As clinical trials begin to assess novel cardiac therapeutics in DMD, troponin levels in DMD are important for safety monitoring and outcome measures. The Parent Project Muscular Dystrophy convened an expert panel of cardiologists, scientists, and regulatory and industry specialists on 16 December 2019 in Silver Spring, Maryland and reviewed published and unpublished data from their institutions. The panel recommended retrospective troponin data analyses, prospective longitudinal troponin collection using high-sensitivity cardiac troponin I assays, inclusion of troponin in future clinical trial outcomes and future development of clinical guidelines for monitoring and treating troponin elevations in DMD.
Chemical and engineering properties of fired bricks containing 50 weight percent of class F fly ash

The generation of fly ash during coal combustion represents a considerable solid waste disposal problem in the state of Illinois and nationwide. In fact, the majority of the three million tons of fly ash produced from burning Illinois bituminous coals is disposed of in landfills. The purpose of this study was to obtain a preliminary assessment of the technical feasibility of mitigating this solid waste problem by making fired bricks with the large volume of fly ash generated from burning Illinois coals. Test bricks were produced by the extrusion method with increasing amounts (20-50% by weight) of fly ash as a replacement for conventional raw materials. The chemical characteristics and engineering properties of the test bricks produced with and without 50 wt% of fly ash substitutions were analyzed and compared. The properties of the test bricks containing fly ash were at least comparable to, if not better than, those of standard test bricks made without fly ash and met the commercial specifications for fi.
Slovak version of the Trail Making Test: Normative data

Abstract The Trail Making Test (TMT) is a popular measure of cognitive functioning, especially processing speed and cognitive flexibility. This study aims to provide normative data for the Slovak adult population. The secondary aim is to test the convergent validity by examining relationships of direct and derived indices to other neuropsychological measures. A sample of 487 healthy adults undertook neuropsychological testing. The relationships of TMT scores to demographic variables and other neuropsychological measures were tested. Age was positively correlated with TMT–A (r = 0.444, p < .01), TMT–B (r = 0.426, p < .01), and the B-A index (r = 0.317, p < .01). Years of education were negatively correlated with TMT–B (r = –0.183, p < .01), B-A difference (r = –0.188, p < .01) and B/A ratio (r = –0.119, p < .01). There were no statistically significant differences in performance based on gender. The test scores were correlated with other measures of processing speed and executive functions. Presented normative data are stratified into 7 age categories. For more accurate interpretation, regression equations were calculated to take years of education into account. TMT-A and B performance, as well as B-A difference score, must be interpreted in relation to age, while education can provide additional information. The B/A ratio is independent from age but should be also corrected for educational level.
Nondestructive Monitoring of Ripeness in Mango Cultivars by Acoustic Resonance Spectroscopy

Mango cultivars, i.e. Neelam, Alphonso, Banganapalli, Totapuri, and Mallige were subjected to acoustic resonance spectroscopy at unripe, semi-ripe, and ripe stages, as well as in case of ripe bruised fruits. The Neelam variety of mango was screened for internal infestation by means of acoustic spectroscopy. Acoustic data on dominant and first frequencies, damping ratio, and firmness indices were obtained and correlated with mechanical penetration tests as well as a/b values of the tristimulus color profile. The correlations between mechanical tests and acoustic parameters varied from 0.81 to 0.933. However, damping ratio and dominant frequency along with firmness index showed a better correlation with penetration test vis-à-vis first frequencies. The correlations between acoustic parameters and a/b tristimulus color values showed lesser extent and significance of correlations ranging from 0.416 to 0.667. The correlations were found to be positive or negative depending on the specific acoustic parameters. However, in the case of internally infested Neelam, the drop in the first frequency was found to be a significant acoustic indicator. Nondestructive quality monitoring by acoustic spectroscopy was found as such to be consistent as far as the tissue softening and bruising are concerned.
Hydrodynamic Alignment of Rodlike Macromolecules During Ultracentrifugation

The effect of intermolecular hydrodynamic interaction on the alignment of rodlike macromolecules during ultracentrifugation is presented. It is shown that the resulting effect is extremely small in magnitude, and in fact predicts a decrease in observed sedimentation coefficient with applied field, which is contrary to experimentally observed properties of the sedimentation coefficient. The intermolecular hydrodynamic interaction mechanism is thereby shown to be unimportant in explaining the origin of this phenomenon. A possible alternative mechanism involving tactoids is briefly discussed.
Detection of Four New Tomato Viruses in Serbia using Post-Hoc High-Throughput Sequencing Analysis of Samples from a Large-Scale Field Survey.

Tomato production worldwide is affected by numerous plant virus species. The early and accurate detection of viruses is a critical step for disease control. However, the simultaneous detection of the most known tomato viruses can be difficult due to the high number and diversity of tomato-infecting viruses. Here, we have identified four new viruses in Serbia by applying target-independent small RNA high-throughput sequencing (HTS). HTS was applied on pools of samples and separate samples, in total comprising 30 tomato samples that exhibited (severe) virus-like symptoms and were collected in Serbia during three annual surveys (2011-2013). These samples had previously tested negative for the presence of 16 tomato viruses using targeted detection methods. Three divergent complete genome sequences of Physostegia chlorotic mottled virus were obtained from different localities, indicating for the first time that this virus is widespread in Serbia and might represent an emergent viral pathogen of tomato. The tomato torrado virus was detected at one locality with devastating yield losses. The southern tomato virus was detected at two localities, and the spinach latent virus was detected at one locality. In addition, we detected the presence of one already known virus in Serbia, the tomato spotted wilt orthotospovirus. All the HTS results were subsequently confirmed by targeted detection methods. In this study, the successful application of post-hoc HTS testing of a limited number of pooled samples resulted in the discovery of new viruses. Thus, our results encourage the use of HTS in research and diagnostic laboratories, including laboratories that have limited resources to resolve disease etiology.