Miracle-dz/UniFAR-FTUs huggingface dataset:
Introduction to Fillers

Background: Over the last few years, injectable soft-tissue fillers have become an integral part of cosmetic therapy, with a wide array of products designed to fill lines and folds and revolumize the face. Methods: This review describes cosmetic fillers currently approved by the Food and Drug Administration and discusses new agents under investigation for use in the United States. Results: Because of product refinements over the last few years—greater ease of use and longevity, the flexibility of multiple formulations within one line of products, and the ability to reverse poor clinical outcomes—practitioners have gravitated toward the use of biodegradable agents that stimulate neocollagenesis for sustained aesthetic improvements lasting up to a year or more with minimal side effects. Permanent implants provide long-lasting results but are associated with greater potential risk of complications and require the skilled hand of the experienced injector. Conclusions: A variety of biodegradable and nonbiodegradable filling agents are available or under investigation in the United States. Choice of product depends on injector preference and the area to be filled. Although permanent agents offer significant clinical benefits, modern biodegradable fillers are durable and often reversible in the event of adverse effects.
Artificial fish skin of self-powered micro-electromechanical systems hair cells for sensing hydrodynamic flow phenomena

Using biological sensors, aquatic animals like fishes are capable of performing impressive behaviours such as super-manoeuvrability, hydrodynamic flow ‘vision’ and object localization with a success unmatched by human-engineered technologies. Inspired by the multiple functionalities of the ubiquitous lateral-line sensors of fishes, we developed flexible and surface-mountable arrays of micro-electromechanical systems (MEMS) artificial hair cell flow sensors. This paper reports the development of the MEMS artificial versions of superficial and canal neuromasts and experimental characterization of their unique flow-sensing roles. Our MEMS flow sensors feature a stereolithographically fabricated polymer hair cell mounted on Pb(Zr0.52Ti0.48)O3 micro-diaphragm with floating bottom electrode. Canal-inspired versions are developed by mounting a polymer canal with pores that guide external flows to the hair cells embedded in the canal. Experimental results conducted employing our MEMS artificial superficial neuromasts (SNs) demonstrated a high sensitivity and very low threshold detection limit of 22 mV/(mm s−1) and 8.2 µm s−1, respectively, for an oscillating dipole stimulus vibrating at 35 Hz. Flexible arrays of such superficial sensors were demonstrated to localize an underwater dipole stimulus. Comparative experimental studies revealed a high-pass filtering nature of the canal encapsulated sensors with a cut-off frequency of 10 Hz and a flat frequency response of artificial SNs. Flexible arrays of self-powered, miniaturized, light-weight, low-cost and robust artificial lateral-line systems could enhance the capabilities of underwater vehicles.
GENETIC ALGORITHMS BASED OPTIMIZATION DESIGN OF TUNNING A PID CONTROLLER

The main aim of this paper is to tune a PID controller to enhance the out put response of fifth order modal with sensor in feedback control system . This controller tuned by genetic algorithms, because the fifth order system is notoriously difficult to control optimally using conventional PID controller. Genetic Algorithms (GA) are effective at finding high performance areas in large domains and the ideal choice to tune the PID controller can be achieved. Genetic Algorithms were examined in detail, it was decided to create an objective function which evaluates the optimum PID gains based on the controlled systems overall error. GA’s outperformed standard tuning practices, e.g. Ziegler Nichols, at designing of PID controllers, in the tests carried out. Experimentally, it can be determined that the Integral Square Error (ISE) performance criterion produces the most effective PID controllers compared with other performance criterion.
Involvement of human immunodeficiency virus type-1 splice sites in the cytoplasmic accumulation of viral RNA.

To define the role of human immunodeficiency virus type 1 splice sites in the cytoplasmic accumulation of viral RNAs, sequential deletion mutagenesis on an infectious proviral clone of HIV-1 was performed. Deletion of the majority of intron sequences, containing previously identified CRS, did not attenuate CRS activity. Retention of either the first or second tat intron preserved CRS activity. RNAs containing splice donor sequences, in the absence of known downstream splice acceptor sequences, retained CRS activity. Unexpectedly, these splice donors were still utilized for splicing. These results indicate that the major HIV-1 splice donors can function as CRS and function to negatively regulate the cytoplasmic accumulation of HIV-1 RNAs in COS cells.
Modeling admissible behavior with net condition/event systems

We address the problem of obtaining a model for the admissible behavior of a discrete event system in the presence of uncontrollable events. We start with a safe Petri net model of the plant and a sequential specification modeled with a special state machine. Then, a combined model of plant and specification is obtained by using the condition and event arcs of net condition/event systems. Using the structure of this combined model, we are able to develop a method to obtain the admissible behavior which avoids the complexity of a complete state enumeration.
Achieving Revenue Benchmarks Conditional on Growth Properties

This study examines whether certain firm characteristics, specifically growth properties, are associated with the likelihood of achieving market expectations for revenues, as well as which mechanism (revenue manipulation or expectation management) growth firms utilize in order to avoid missing these expectations. The results show that growth firms are more likely to meet or exceed analyst revenue forecasts than non-growth firms. We also find that growth firms are more inclined to manipulate their reported revenues upwards, and less inclined to guide market expectations for revenues downward, in order to meet or beat expected revenues relative to non-growth firms. These findings suggest that window-dressing activities by growth firms may not be sustainable in the long-run and can misguide users of financial statements in their decision-making.
The diagnostic and prognostic value of tissue Doppler imaging during dobutamine stress echocardiography in end-stage renal disease

ObjectiveTo determine whether a quantitative measurement of peak systolic velocity (PSV) during dobutamine stress echocardiography (DSE) detects severe coronary artery disease (CAD) and predicts mortality in patients with end-stage renal disease. MethodsOne hundred and forty renal transplant candidates had DSE and coronary angiography. DSE analysis was performed using conventional visual wall motion assessment, longitudinal PSV, and combining the two modalities. Failure of PSV to rise by more than 50% predicted an ischemic response. Significant CAD was defined as luminal stenosis greater than 70%. ResultsThe number of positive DSE studies according to conventional, PSV, and combined criteria was 41 (30%), 42 (31%), and 46 (34%) respectively. Forty patients (29%) had significant CAD at angiography. The sensitivity, specificity, positive and negative predictive values for conventional DSE analysis were 84, 91, 86, and 90% respectively. The same values for PSV analysis were 86, 92, 86, and 91%, respectively. The same values for the combination of visual and PSV analysis were 88, 94, 87, and 92% respectively. The differences between the three methods were not statistically significant. Sensitivity for single-vessel CAD (P=0.05) and circumflex artery disease (P=0.05) diagnosis was higher with PSV compared with conventional DSE analysis. Failure of PSV to rise by more than 50% during DSE was associated with significantly increased mortality (P=0.001). ConclusionA quantitative interpretation of DSE, based on the percentage rise of PSV during stress, accurately detects CAD and predicts prognosis in end-stage renal disease.
Percutaneous maxacalcitol injection therapy regresses hyperplasia of parathyroid and induces apoptosis in uremia.

BACKGROUND A high level of parathyroid hormone (PTH) is considered to be an indicator of poor prognosis and a poor quality of life of dialysis patients; therefore, an effective and safe therapy for secondary hyperparathyroidism (SHPT) has been developed. METHODS In 20 patients with SHPT resistant to maxacalcitol (OCT) intravenously administered, all detectably enlarged parathyroid glands were treated by percutaneous maxacalcitol injection therapy (PMIT) under ultrasonographic guidance consecutively 6 times, which was followed by OCT that was intravenously administered. The clinical effects of PMIT were evaluated based on the changes in the serum intact-PTH, adjusted Ca, phosphorus, and bone marker levels, and the parathyroid gland volume determined by ultrasonography. Morphologic examination, apoptosis analysis, and PTH mRNA expression level determination by reverse transcription-polymerase chain reaction (RT-PCR) using parathyroid tissues obtained by a biopsy technique were performed. RESULTS PMIT and subsequent intravenous OCT administrations significantly decreased the serum intact-PTH level and parathyroid gland volume for at least 12 weeks after PMIT without major complications. Parathyroid tissues obtained after PMIT exhibited some partial defects of parathyroid cells, a marked increase in the number of the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive cells, the ladder formation determined by DNA electrophoresis, and the decrease in the PTH mRNA expression level. CONCLUSION PMIT is effective and safe for the treatment of refractory SHPT, and a locally high level of OCT suppresses PTH secretion and regresses parathyroid hyperplasia, which is involved in the induction of apoptosis of parathyroid cells.
An Explicit Unconditionally Stable Numerical Method for Solving Damped Nonlinear Schrödinger Equations with a Focusing Nonlinearity

This paper introduces an extension of the time-splitting sine-spectral (TSSP) method for solving damped focusing nonlinear Schrodinger equations (NLSs). The method is explicit, unconditionally stable, and time transversal invariant. Moreover, it preserves the exact decay rate for the normalization of the wave function if linear damping terms are added to the NLS. Extensive numerical tests are presented for cubic focusing NLSs in two dimensions with a linear, cubic, or quintic damping term. Our numerical results show that quintic or cubic damping always arrests blowup, while linear damping can arrest blowup only when the damping parameter ${\delta}$ is larger than a threshold value ${\delta}_{\rm th}$. We note that our method can also be applied to solve the three-dimensional Gross-Pitaevskii equation with a quintic damping term to model the dynamics of a collapsing and exploding Bose-Einstein condensate (BEC).
The role of the board commissioners in the implementation of the principles of good corporate governance and the achievement of the performance of bank perkreditan rakyat in tasikmalaya

This study aims to determine: the effect of the role of the commissioners, to the implementation of the principles of good corporate governance, the influence of the role of the commissioners and the implementation of the principles of corporate governance either partially or simultaneously on the performance of Bank Perkreditan Rakyat in Tasikmalaya. The method used a quantitative descriptive study population is a Bank Perkreditan Rakyat in Tasikmalaya, sampling using purposive sampling technique, with analysis tools using path analysis. The results showed that: the role of the board of commissioners, the implementation of the principles of corporate governance and bank performance generally categorized as good; the role of commissioner to the application of the principles of good corporate governance positively and significantly; and, the role of the commissioner and the application of the principles of good corporate governance partially and simultaneously on the performance of positive and significant influence.
Temporary threshold shift after impulse-noise during video game play: Laboratory data

Abstract Objective: Prevention of temporary threshold shift (TTS) after laboratory-based exposure to pure-tones, broadband noise, and narrowband noise signals has been achieved, but prevention of TTS under these experimental conditions may not accurately reflect protection against hearing loss following impulse noise. This study used a controlled laboratory-based TTS paradigm that incorporated impulsive stimuli into the exposure protocol; development of this model could provide a novel platform for assessing proposed therapeutics. Design: Participants played a video game that delivered gunfire-like sound through headphones as part of a target practice game. Effects were measured using audiometric threshold evaluations and distortion product otoacoustic emissions (DPOAEs). The sound level and number of impulses presented were sequentially increased throughout the study. Study sample: Participants were normal-hearing students at the University of Florida who provided written informed consent prior to participation. Results: TTS was not reliably induced by any of the exposure conditions assessed here. However, there was significant individual variability, and a subset of subjects showed TTS under some exposure conditions. Conclusions: A subset of participants demonstrated reliable threshold shifts under some conditions. Additional experiments are needed to better understand and optimize stimulus parameters that influence TTS after simulated impulse noise.
Rabbit alveolar macrophage damage caused by in vivo ozone inhalation.

The osmotic fragility of alveolar macrophages recovered from ozone-exposed rabbits was determined, using a fragiligraph. Lung lavage resulted in smaller recoveries of lung cells from rabbits exposed to 10 ppm of ozone for three hours, and the percentage of macrophages was decreased. Chronic low-dose exposures for a week did not affect the total number of recoverable lung cells but did result in increases in the percentage of neutrophils. The average time in minutes (± standard deviation) for complete lysis of control alveolar macrophages was 33.0 ± 6. ,5 and 24.0 ± 2.2 (P < 0.05) for the acute 10-ppm ozone exposed cellsm Complete lysis times for the chronic 2 ppm and 0.5-ppm exposed cells were 25.2 ± 5.4 (P < 0.05) and 33.3 ± 7.5 (P, not significant), respectively, These changes in macrophage osmotic fragility occurred in the absence of detectable lipid peroxidation.
Mining and Organizing a Resource of State-changing Verbs

Most knowledge bases (KBs) that emerged in recent years are static. They contain facts about the world yet are seldom updated as the world changes: attributes or possessions of entities in the KB change over time; what (actions) the entities can do or what can be done to them change over time. Current methods for extracting facts in the KBs do not yet detect such state changes although these changes have implications for the correctness of the KB. We propose a method for learning change-of-states in entities that are brought about by event-expressing verbs acting on the entities. These change of states in entities can be viewed as KB updates of facts pertaining to these entities. We envision a resource of state changing verbs, that contains preand post-conditions of each verb on its arguments: the entry condition of entities that allow an event expressed by the verb to take place and the condition of entities that will be true after the event occurs. When a state changing verb acts on an entity or when the entity’s state change is detected in text, we can use the resource to update KB facts about the entity.
ENDOGENOUS GLUTATHIONE PROTECTS HUMAN SKIN FIBROBLASTS AGAINST THE CYTOTOXIC ACTION OF UVB, UVA AND NEAR‐VISIBLE RADIATIONS

Both the UVB (290‐320 nm) and UVA (320‐380 nm) regions of sunlight damage human skin cells but, particularly at the longer wavelengths, information is scant concerning the mechanism(s) of damage induction and the roles of cellular defense mechanisms. Following extensive glutathione depletion of cultured human skin fibroblasts, the cells become strongly sensitized to the cytotoxic action of near‐visible (405 nm), UVA (334 nm, 365 nm) and UVB (313 nm) but not UVC (254 nm) radiations. In the critical UVB region, the magnitude of the protection afforded by endogenous glutathione approaches that of the protection provided by excision repair. The results suggest that a significant fraction of even UVB damage can be mediated by free radical attack and that a major role of glutathione in human skin cells is to protect them from the cytotoxic action of sunlight.
Development of a Mobile Manipulator System with RFID-Based Sensor Fusion for Home Service: a Case Study on Mobile Manipulation of Chairs

A mobile manipulator system as a versatile platform for home service has been developed by authors toward practical realizations. Two features of the system are addressed. One is the efficient and easy recognition of environment and objects about geometrical, physical and additional information by an RFID (Radio Frequency IDentification)-based sensor fusion system. The other is such geometrical, physical and additional information-based manipulation including mobile manipulation for various objects. In this paper, mobile manipulation of various chairs for home service is described. The methods for recognition and mobile manipulation are proposed and experimental results are given to show the feasibility of the proposed methods.
Création par évolution dirigée de protéines artificielles en alternatives aux anticorps

Les travaux decrits dans ce memoire ont pour objectif d’une part le developpementd’une nouvelle famille de proteines artificielles et d’autre part la creation de nouveaux sitesde fixation specifiques dans ces proteines. L’objectif general etait de developper une approchegenerale permettant d’obtenir rapidement des proteines reconnaissant toute macromoleculecible choisie. On peut voir ces proteines artificielles specifiques comme des sortes d’anticorpsartificiels pour leur specificite et leur affinite mais dont les proprietes physiques : stabilite,solubilite, efficacite d’expression, insensibilite a l’agregation sont nettement plus favorablesque celles des anticorps et de leur derives.Le premier chapitre, presente la conception et la construction d’une bibliotheque deproteines artificielles dite de premiere generation ou les proteines sont formees par larepetition d’un motif idealise a partir d’une famille de motifs naturels appeles HEAT repeats.Toutes les proteines de la bibliotheque, denommees αRep, sont concues pour avoir la memearchitecture generale mais different les unes des autres par le nombre de motifs et par lasequence dans certaines positions rendues variables au sein de chaque motif. Cette banquenous a permis de valider l’architecture αRep choisie : Les proteines s’expriment sous formesoluble, sont tres stables et adoptent la structure secondaire et tertiaire attendue quel que soitla sequence des positions hypervariables. Le second chapitre presente alors les approchessuivies pour l’amelioration de la qualite et de la diversite de la bibliotheque et a conduit a laconstruction d’une bibliotheque d’αRep de deuxieme generation. Cette derniere bibliotheque(2 .1) repose sur le meme schema general mais contient une diversite ayant ete optimiseelors de la conception puis amelioree experimentalement par une procedure dite deFiltration/shuffling. Cette bibliotheque tres diverse (1.7*109 clones independants) a ete alorsexploitee pour y rechercher, par des methodes d’exposition sur phages, de nouvelles αRepreconnaissant des proteines cibles prealablement choisies. L’ensemble des resultats montretres clairement que des αRep reconnaissant specifiquement, avec une affinite elevee, desproteines cibles choisies arbitrairement peuvent etre effectivement obtenues. Les structurestridimensionnelles de plusieurs complexes formes entre les αRep et leur cible a ete resoluepermet de comprendre la nature et l’organisation precise de ces capacites de reconnaissancemoleculaire nouvellement creees.
Ensuring Service Resilience in the EPS: MME Failure Restoration Case

In the Evolved Packet System, service resiliency can be heavily impacted by a node failure in its control plane. Ensuring service resiliency in EPS via defining efficient and proactive restoration mechanisms is of vital importance. In this paper, we address the case of MME failure. We propose schemes for MME failure detection and restoration considering both UEs in idle mode and UEs in active mode. As a MME failure may concern a potential number of UEs, network overload control, via randomized paging and handling signaling messages in bulk, is considered. The proposed schemes are evaluated through simulations and encouraging results are obtained.
Calcul theorique de constantes de vitesse de reactions thermiques, pour un comportement reel des gaz. Application a l'etude de reactions elementaires dans les domaines de la combustion et de l'atmosphere

Dans cette these, nous abordons le calcul d'une constante de vitesse par la theorie de l'etat de transition. Apres un premier chapitre de presentation de cette theorie et des outils de la chimie quantique, nous presentons dans le second chapitre des resultats dans les domaines de la combustion, de la detonation et de l'atmosphere. D'une maniere generale nous avons constate sur les exemples traites, que la methode mrci conduit aux meilleurs resultats (justifiant son cout de calcul tres eleve par rapport aux autres methodes). La qualite du resultat va alors au dela du simple ordre de grandeur, pour des systemes comprenant 11 et 23 electrons. Les methodes casscf et hf-dft/b3lyp respectivement surestiment et sous-estiment la barriere d'energie electronique. Les methodes mp4 et bac-mp4 sont irregulieres et insuffisantes. A l'oppose, la methode caspt2 approche la qualite du resultat mrci pour deux reactions, mais dans deux autres cas, exagere la correction apportee a la valeur casscf conduisant a une surestimation flagrante de la constante de vitesse. D'autres etudes sont necessaires pour mieux cerner les possibilites de cette recente methode. Dans le dernier chapitre, nous presentons un modele qui traduit la non-idealite des gaz a haute pression par la presence d'un facteur multiplicateur place devant la constante de vitesse k. Une etude ulterieure devra preciser le role de l'effet des interactions sur la frequence de dissociation du complexe active. Une application numerique realisee sur l'equilibre de synthese de l'ammoniac a permis de valider le modele, et a montre par le biais du facteur d'interaction que le comportement gaz reel pouvait s'eloigner du comportement gaz parfait d'un facteur 3 a 600 atmospheres pour ce systeme.