Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship of Separation and Depression to Disease: I. A Report on a Hospitalized Medical Population

&NA; This is one of a series of studies being made to investigate the relationship of “separation and depression” to the onset of medical disease. In this report a group of 42 semiprivate hospitalized medical patients between the ages of 18 and 45 was studied for predisease setting based on reported object‐relationship changes and reported and observed major affective reactions to such changes. Twenty‐nine patients and/or family members reported loss of an object and feelings of helplessness and hopelessness immediately preceding the onset of the symptoms of the illness which led to hospitalization. Five patients reported feelings of helplessness or hopelessness prior to the onset of symptoms but reported no loss of an object. In 41 of the 42 patients the investigator felt that there was verbal and/or nonverbal evidence for the interpretation of actual, threatened, or symbolic object loss as well as evidence for feelings of helplessness or hopelessness prior to the onset of disease. Thirty‐one patients developed the onset of their disease within one week after what was considered the final or only change in relationship to which the patient experienced a feeling of helplessness or hopelessness. Early life losses or threats of loss, past conflicts reawakened or still unresolved, and the incidence of past separations preceding changes in past health of this group of patients were also reported. "Separation and depression" as defined refers to the psychic pattern of unsuccessful resolution of object loss. Starting with a change in a relationship, this concept involves the actual or fantasied loss of an object upon which the self has real or symbolic dependence and includes the attempts and final failures to reestablish or give up the lost or threatened relationship, as evidenced by feelings of helplessness or hopelessness. Case examples are appended to illustrate how the setting of the current disease onset was reported and how the investigator made his interpretations of this material.
Predictors of Cancer Screening Among Culturally Diverse Men

Men have higher rates of all cancers and are more likely to die from cancer than women; however, men are less likely to utilize disease prevention services. African American/Black men and Hispanic men have lower cancer survival rates and are less likely to utilize health care services than non-Hispanic White men. The present study examined demographic variables (age, household income, education, marital status, race/ethnicity, health insurance status), motivators to engage in healthy eating, and motivators to engage in physical activity as predictors of culturally diverse, medically underserved men’s likelihood of getting a cancer screening (a) at the present time, (b) if no cancer symptoms are present, and (c) if a doctor discovers some cancer symptoms. Analyses were conducted using data from 243 men (47.3% non-Hispanic Black, 29.5% Hispanic, 16.5% non-Hispanic White, and 6.8% “other”) recruited at the Men’s Health Forum in Tampa, Florida. Age, having a medical or health condition that benefits from eating healthy, and having a commitment to physical activity were significant positive predictors of the likelihood of receiving a cancer screening. Motivation to engage in physical activity because of a personal priority was a significant negative predictor of the likelihood of getting a cancer screening. The findings from this study suggest that interventions to increase cancer screenings among culturally diverse, medically underserved men should be informed at least in part by an assessment of participating men’s motivators for engaging in health promoting lifestyle behaviors such as physical activity and healthy eating.
Changes in Peritoneal Transport during the First Month of Peritoneal Dialysis

Objective To determine if peritoneal transport characteristics change during the initial month of peritoneal dialysis. Design Retrospective review of peritoneal equilibration test (PET) results in patients who received their first PET during the first two weeks of peritoneal dialysis (early PET group) versus patients who received their first PET between four and 28 weeks after the initiation of dialysis (late PET group). The initial PET values were compared to subsequent PET results obtained approximately seven months after the initial PET. Setting Peritoneal dialysis unit of a tertiary medical center. Outcome Measures PET results and calculated mass transfer area coefficient (MT AC) values. Patients Thirty-four peritoneal dialysis patients in the early PET group and 17 peritoneal dialysis patients in the late PET group. Results In the early PET group, there was a statistically significant increase from the initial to follow-up values for both dialysate-to-plasma (DIP) creatinine and MTAC creatinine (p < 0.01) as well as a significant decrease for four-hour dialysate to initial dialysate ratios (DID) glucose (p = 0.08) and MTAC glucose (p < 0.05). In the late PET group, there was no significant change in any of these parameters with time. However, in the late PET group, there was a significant decrease in DIP urea values with time (p < 0.01), but not with MTAC urea. In addition, there were no differences over time in either group for serum albumin or hematocrit values. Conclusion During the first two weeks of peritoneal dialysis, there tends to be a change in peritoneal transport characteristics in some patients. PET data obtained during this time period should be interpreted as preliminary.
Contemporary methods of body composition measurement

Reliable and valid body composition assessment is important in both clinical and research settings. A multitude of methods and techniques for body composition measurement exist, all with inherent problems, whether in measurement methodology or in the assumptions upon which they are based. This review is focused on currently applied methods for in vivo measurement of body composition, including densitometry, bioimpedance analysis, dual‐energy X‐ray absorptiometry, computed tomography (CT), magnetic resonance techniques and anthropometry. Multicompartment models including quantification of trace elements by in vivo neutron activation analysis, which are regarded as gold standard methods, are also summarized. The choice of a specific method or combination of methods for a particular study depends on various considerations including accuracy, precision, subject acceptability, convenience, cost and radiation exposure. The relative advantages and disadvantages of each method are discussed with these considerations in mind.
Modulation of cardiac Na(+)-K+ pump current: role of protein and nonprotein sulfhydryl redox status.

Oxidant stress alters protein structure and function, possibly through the modification of the redox status of regulatory protein sulfhydryl groups. We used the sulfhydryl-blocking reagent p-chloromercuriphenylsulfonic acid (pCMPSA), applied selectively and independently to either the intracellular or extracellular environment, to study the relationship between blocking protein sulfhydryl groups and Na(+)-K+ pump current (i.p.). In guinea pig ventricular myocytes voltage clamped at -30 mV, extracellular pCMPSA (50, 100, and 400 microM) caused a concentration-dependent reduction in holding current. The selective intracellular administration of pCMPSA (100 microM) induced a similar inhibition of i.p., albeit over a longer time course. The inhibition of ip resulting from either the intracellular or extracellular application of pCMPSA (100 microM) was reversed, in part, by the extracellular application of dithiothreitol (3 mM). An intracellular oxidant stress was also imposed by using diethyl maleate to deplete the intracellular nonprotein sulfhydryl content [represented by reduced glutathione (GSH)]. In myocytes isolated from diethyl maleate-treated guinea pigs *860 mg/kg i.p., 30 min before study), intracellular GSH was depleted by 93% and i.p. was depressed by 38% at all membrane potentials tested. We propose that Na(+)-K+ pump function may be related to protein and nonprotein sulfhydryl status. Protein sulfhydryl oxidation and glutathione depletion may account, in part, for a depression in Na(+)-K+ pump activity during reperfusion-induced oxidant stress.
Spectrally weighted transparency in models of water-column photosynthesis and photoinhibition by ultraviolet radiation

We present a simple method for describing the influence of variable attenuation of spec- tral irradiance, Kd(λ), on water-column photosynthesis and its inhibition by ultraviolet radiation (UV). The approach is based on weighted water transparency, a calculation introduced by Vincent et al. 1998 (Ann Glaciol 27:691-696). Key results of a depth- and spectrally-resolved model of photosyn- thesis can be reproduced for a broad range of water types by simple parameterizations using a refer- ence solar irradiance spectrum at the surface and water transparency (1/Kd(λ)) weighted spectrally for biological effectiveness. Transparency that has been weighted spectrally by the normalized prod- uct of irradiance and photosynthetic absorption (PUR-weighted transparency, T W) describes spec- tral effects on photosynthesis in the water column. An empirical parameterization of transparency weighted by the product of surface irradiance and the biological weighting function for inhibition of photosynthesis (T W PIR), along with T W PUR, describes the inhibition of water-column photosynthesis rela- tive to the uninhibited rate. Our approach is directly compared with an analysis that used weighted transparency as an indicator of the potential for inhibition of photosynthesis by UV as influenced by variations in chromophoric dissolved organic matter associated with climate change over the past 6000 yr (Pienitz & Vincent 2000, Nature 404:484-487). Results demonstrate how weighted trans- parency, used as an indicator of potential inhibition, can be transformed into a predictor of biological effects.
The influence of financial leverage on bid-ask spread through market capitalization: A study on companies listed in LQ 45 index

This study is aimed to examine empirically the influence of financial leverage on bid-ask spread through market capitalization. The population are companies that listed in the LQ45 Index during periods 2011-2012. This study uses 35 companies listed in the LQ45 index during periods 2011-2012 as many as 70 observations. Data are collected from Indonesian Capital Market Directory. This study uses path analysis to examine the hypothesis. The results show that (1) the influence of financial leverage on market capitalization is negative. (2) the influence of market capitalization on bid-ask spread is also negative. (3) the influence of financial leverage on the bid-ask spread is positive. (4) simultaneously, financial leverage and market capitalization have influence on bid-ask spread. Indirectly, financial leverage has influence on bid-ask spread through the market capitalization. Then, direct influence of financial leverage on the bid-ask spread is stronger than indirect influence of financial leverage on the bid-ask spread through the market capitalization. Therefore, it can be stated that the real influence of financial leverage on bid-ask spread is direct influence. Keywords: Bid-Ask Spread, Financial Leverage and Market Capitalization.
Soybean seed: A treasure trove of bioactive compounds

OPEN ACCESS This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http:// creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact reprints@pulsus.com Soybean seed: A treasure trove of bioactive compounds
[Surgical treatment of secondary hyperparathyroidism].

BACKGROUND Surgical treatment in the patient effected by secondary hyperparathyroidism consists in subtotal parathyroidectomy or total parathyroidectomy plus autotransplantation of parathyroid tissue. METHODS The results obtained with surgical treatment of 6 patients observed in the years 1995-1996 are analyzed. Two glands were hyperplastic in four patients, 3 in the others. Every patient was submitted to a subtotal parathyroidectomy. RESULTS Postoperative course was marked by transient hypoparathyroidism in one case. After 18 months of follow-up, no recurrences were observed. CONCLUSIONS It is pointed out that in case of secondary hyperparathyroidism subtotal parathyroidectomy represents the surgical treatment of choice, according with literature data. Otherwise total parathyroidectomy plus autotransplantation, characterized by a more complex surgical technique, lead to the same results.
A primate subfamily of galectins expressed at the maternal–fetal interface that promote immune cell death

Galectins are proteins that regulate immune responses through the recognition of cell-surface glycans. We present evidence that 16 human galectin genes are expressed at the maternal–fetal interface and demonstrate that a cluster of 5 galectin genes on human chromosome 19 emerged during primate evolution as a result of duplication and rearrangement of genes and pseudogenes via a birth and death process primarily mediated by transposable long interspersed nuclear elements (LINEs). Genes in the cluster are found only in anthropoids, a group of primate species that differ from their strepsirrhine counterparts by having relatively large brains and long gestations. Three of the human cluster genes (LGALS13, -14, and -16) were found to be placenta-specific. Homology modeling revealed conserved three-dimensional structures of galectins in the human cluster; however, analyses of 24 newly derived and 69 publicly available sequences in 10 anthropoid species indicate functional diversification by evidence of positive selection and amino acid replacements in carbohydrate-recognition domains. Moreover, we demonstrate altered sugar-binding capacities of 6 recombinant galectins in the cluster. We show that human placenta-specific galectins are predominantly expressed by the syncytiotrophoblast, a primary site of metabolic exchange where, early during pregnancy, the fetus comes in contact with immune cells circulating in maternal blood. Because ex vivo functional assays demonstrate that placenta-specific galectins induce the apoptosis of T lymphocytes, we propose that these galectins reduce the danger of maternal immune attacks on the fetal semiallograft, presumably conferring additional immune tolerance mechanisms and in turn sustaining hemochorial placentation during the long gestation of anthropoid primates.
Relational Regularization and Feature Ranking

Regularization is one of the key concepts in machine learning, but so far it has received only little attention in the logical and relational learning setting. Here we propose a regularization and feature selection technique for such setting, in which one commonly represents the structure of the domain using an entity-relationship model. To this end, we introduce a notion of locality that ties together features according to their proximity in a transformed representation of the relational learning problem obtained via a procedure that we call “graphicalization”. We present two techniques, a wrapper and an eﬃcient embedded approach, to identify the most relevant sets of predicates which yields more readily interpretable results than selecting low-level proposition-alized features. The proposed techniques are implemented in the kernel-based relational learner kLog, although the ideas presented here can also be adapted to other relational learning frameworks. We evaluate our approach on classiﬁcation tasks in the natural language processing and bioinformatics domain.
Social anxiety disorder and the risk of depression: a prospective community study of adolescents and young adults.

BACKGROUND Social anxiety disorder (SAD) (also known as "social phobia") is frequently comorbid with major depression, and in such cases, almost always precedes it. This has led to interest in SAD as a possible modifier of the risk and/or course of mood disorders. METHODS Data come from a prospective, longitudinal epidemiologic study of adolescents and young adults (aged 14-24 years) in Munich, Germany. Respondent diagnoses (N = 2548) at baseline and follow-up (34-50 months later) are considered. The influence of SAD at baseline on the risk, course, and characteristics of depressive disorders (ie, major depression or dysthymia) at follow-up is examined. RESULTS The baseline prevalence of SAD was 7.2% (95% confidence interval [CI], 6.1%-8.4%). Social anxiety disorder in nondepressed persons at baseline was associated with an increased likelihood (odds ratio [OR] = 3.5; 95% CI, 2.0-6.0) of depressive disorder onset during the follow-up period. Furthermore, comorbid SAD and depressive disorder at baseline was associated with a worse prognosis (compared with depressive disorder without comorbid SAD at baseline). This is exemplified by the greater likelihood of depressive disorder persistence or recurrence (OR = 2.3; 95% CI, 1.2-4.6) and attempted suicide (OR = 6.1; 95% CI, 1.2-32.2). CONCLUSIONS Social anxiety disorder during adolescence or young adulthood is an important predictor of subsequent depressive disorders. Moreover, the presence of comorbid SAD in adolescents who are already depressed is associated with a more malignant course and character of subsequent depressive illness. These findings may inform targeted intervention efforts.
A treatment algorithm for the management of cervical spine fractures and deformity in patients with ankylosing spondylitis.

OBJECT Patients with ankylosing spondylitis (AS) who present with cervical spine fractures represent a unique challenge to spine surgeons. These injuries often result in neurological deficits that necessitate early and aggressive surgical management with posterior and/or anterior fixation. The authors introduce a clinical problem-solving algorithm to assist in the surgical management of instability and deformity in this exigent patient population. METHODS Thirteen patients with AS and fractures of the cervical spine were radiographically evaluated to determine if spinal realignment was obtainable with cervical manipulation or traction. Seven patients had flexible deformities that were stabilized with either anterior or posterior fixation only, and 6 patients had fixed deformities and required circumferential anterior-posterior instrumentation. All patients were observed for neurological outcome, radiographic evidence of bone fusion, and complications. RESULTS With the use of the authors' treatment algorithm, all patients were able to achieve satisfactory spinal realignment and bone fusion; 92% of patients achieved postoperative stability or improvement in Nurick and modified Japanese Orthopaedic Association scale scores. One patient experienced neurological deterioration following surgery, and 1 patient died at an acute rehabilitative facility following discharge. CONCLUSIONS Patients with AS are highly susceptible to extensive neurological injury and spinal deformity after sustaining cervical fractures from even minor traumatic forces. These injuries are uniquely complex in nature and require considerable scrutiny and aggressive surgical management to optimize spinal stability and functional outcomes. The authors' clinical problem-solving algorithm will assist spine surgeons in providing optimal care in this difficult population.
Knowledge elicitation and integration from multiple experts

The idea of this paper is based upon the belief that each person has his (or her) own habitual domain, in which he (or she) used to solve problems by his (or her) own way. If a person's habitual domain can not cover the problem to be solved, he (or she) will feel diffident and uneasy, and incorrect decisions may be made. For an expert to solve a problem within his (or her) habitual domain, overconfidence and ignorance may sometimes lead to mistakes. To cope with these problems, a knowledge acquisition method for multiple experts, MERGE, is proposed. Some experimental results on a practical application have shown that MERGE is able to enrich the elicited knowledge and improve the performance of the constructed expert systems by integrating expertise from multiple experts. <<ETX>>
Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis.

AIM Adipokines are protein products of adipose tissue with paracrine and endocrine actions, which have been implicated in the pathogenesis of cardiovascular disease. Locally produced adipokines, especially by periadventitial adipose tissue, may affect vascular physiology and pathology. We investigated the expression of adiponectin, visfatin, leptin and novel adipokines chemerin and vaspin in human periaortic and epicardial adipose tissue, as well as their correlation to aortic and coronary atherosclerosis. METHODS Standard immunohistochemical staining for the adipokines was performed on samples of human periaortic, pericoronary and apical epicardial adipose tissue. Atherosclerotic lesions of the adjacent vascular wall were assessed using the AHA classification. RESULTS Adipokines were expressed in periadventitial and apical epicardial adipose tissue and - except for adiponectin - in vascular smooth muscle cells and foam cells in atherosclerotic lesions. Aortic atherosclerosis was positively correlated with chemerin, vaspin, visfatin and leptin periaortic fat expression. Coronary atherosclerosis was positively correlated with chemerin and visfatin pericoronary fat expression. Adipose tissue adiponectin expression was negatively correlated to atherosclerosis in both locations. Expression of adipokines in apical epicardial fat was not associated with atherosclerosis. CONCLUSIONS Our results show: a) a different expression pattern of adiponectin, visfatin, leptin, chemerin and vaspin in periaortic, pericoronary and apical epicardial adipose tissue, b) a correlation of these adipokines with either aortic or coronary atherosclerosis or both in a pattern characteristic for each adipokine and suggest that locally produced adipokines might differently affect the atherosclerotic process in different locations.
Non-Local Means Denoising

We present in this paper a new denoising method called non-local means. The method is based on a simple principle: replacing the color of a pixel with an average of the colors of similar pixels. But the most similar pixels to a given pixel have no reason to be close at all. It is therefore licit to scan a vast portion of the image in search of all the pixels that really resemble the pixel one wants to denoise. The paper presents two implementations of the method and displays some results. license. A C/C++ implementation is provided. Please see the readme ﬁle or the online documentation for details.