Miracle-dz/UniFAR-FTUs huggingface dataset:
Opinion Mining from Online User Reviews Using Fuzzy Linguistic Hedges

Nowadays, there are several websites that allow customers to buy and post reviews of purchased products, which results in incremental accumulation of a lot of reviews written in natural language. Moreover, conversance with E-commerce and social media has raised the level of sophistication of online shoppers and it is common practice for themto compare competing brands of products before making a purchase. Prevailing factors such as availability of online reviews and raised end-user expectations have motivated the development of opinion mining systems that can automatically classify and summarize users' reviews. This paper proposes an opinion mining system that can be used for both binary and fine-grained sentiment classifications of user reviews. Feature-based sentiment classification is amultistep process that involves preprocessing to remove noise, extraction of features and corresponding descriptors, and tagging their polarity. The proposed technique extends the feature-based classification approach to incorporate the effect of various linguistic hedges by using fuzzy functions to emulate the effect of modifiers, concentrators, and dilators. Empirical studies indicate that the proposed system can perform reliable sentiment classification at various levels of granularity with high average accuracy of 89% for binary classification and 86% for fine-grained classification.
A diabetes-specific e-mental health tool: Development, acceptability and outcomes of a feasibility study.

BACKGROUND Psychological problems are frequently comorbid with diabetes and can be complex and time consuming to manage in general practice. They can also complicate diabetes management. OBJECTIVE This pre-post, mixed-methods study examined whether a diabetes-specific online module, integrated into an existing e-mental health program, is acceptable to patients and helps to improve psychological wellbeing. METHODS The study was conducted in three stages. First, qualitative information was obtained from consumers and practitioners to inform module content. Second, clinical content for the module was developed, including psychoeducational material and clinical content. In the final stage, acceptability and feasibility was evaluated in a group of patients with diabetes. RESULTS Patients' satisfaction with and acceptance of the module was high. Significant improvement in mental health and diabetes outcomes was also observed. DISCUSSION Preliminary evidence suggests that the online diabetes module may be a useful psychological support for patients with diabetes. Further controlled investigation is warranted.
NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism.

SIGNIFICANCE The nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular redox homeostasis and for modulating numerous biological events, including cellular metabolism. Deficiency or imbalance of these two redox couples has been associated with many pathological disorders. Recent Advances: Newly identified biosynthetic enzymes and newly developed genetically encoded biosensors enable us to understand better how cells maintain compartmentalized NAD(H) and NADP(H) pools. The concept of redox stress (oxidative and reductive stress) reflected by changes in NAD(H)/NADP(H) has increasingly gained attention. The emerging roles of NAD+-consuming proteins in regulating cellular redox and metabolic homeostasis are active research topics. CRITICAL ISSUES The biosynthesis and distribution of cellular NAD(H) and NADP(H) are highly compartmentalized. It is critical to understand how cells maintain the steady levels of these redox couple pools to ensure their normal functions and simultaneously avoid inducing redox stress. In addition, it is essential to understand how NAD(H)- and NADP(H)-utilizing enzymes interact with other signaling pathways, such as those regulated by hypoxia-inducible factor, to maintain cellular redox homeostasis and energy metabolism. FUTURE DIRECTIONS Additional studies are needed to investigate the inter-relationships among compartmentalized NAD(H)/NADP(H) pools and how these two dinucleotide redox couples collaboratively regulate cellular redox states and cellular metabolism under normal and pathological conditions. Furthermore, recent studies suggest the utility of using pharmacological interventions or nutrient-based bioactive NAD+ precursors as therapeutic interventions for metabolic diseases. Thus, a better understanding of the cellular functions of NAD(H) and NADP(H) may facilitate efforts to address a host of pathological disorders effectively. Antioxid. Redox Signal. 28, 251-272.
Juglone ameliorates skin wound healing by promoting skin cell migration through Rac1/Cdc42/PAK pathway

Skin cell regeneration and wound healing are key processes in the recovery from skin injuries. Rapid cell migration and regeneration of skin cells lead to faster and better healing of wounded skin. In the present study, we aimed to investigate the wound healing potential of juglone, a naturally occurring Pin1 inhibitor found in walnuts. Cultured skin cells (NHDF and HaCaT) and hairless mice were treated with juglone after wound creation to examine its effects on cell migration and wound healing rate. The expressions of cell migration related proteins (Rac1, Cdc42, and α‐PAK), collagen deposition, and angiogenesis were analyzed. Juglone treatment resulted in faster rate of growth and migration and recovered cell morphology, particularly at a concentration of 5 µM, in skin cells compared to the untreated group. In vivo experiments showed that mice treated with juglone showed faster wound healing rate with better skin morphology and collagen deposition than the vehicle group. Furthermore, juglone increased the activation and/or expression of Cdc42, Rac1, and α‐pak in HaCaT cells, and resulted in enhanced angiogenesis in endothelial cells (HUVECs). Juglone also activated MAPKs signaling by activation of ERK, JNK, and p38 proteins. Taken together, these data suggest that juglone may be a potential candidate for wound healing and skin regeneration which ameliorates wound healing mainly by promoting skin cell migration through Rac1/Cdc42/PAK pathway.
How fundamental plant functional trait relationships scale‐up to trade‐offs and synergies in ecosystem services

1. Ecosystem services (ES) lie at the core of the interactions among humans and ecosystems. Fundamental understanding of the ecological mechanisms underlying the simultaneous provision of multiple ES has been lagging behind policy and management needs and stands out as a research priority. In this paper, we focus on interactions between ES resulting from fundamental functional mechanisms.
Production , Manufacturing and Logistics Contracting with asymmetric demand information in supply chains

We solve a buyback contract design problem for a supplier who is working with a retailer who possesses private information about the demand distribution. We model the retailer’s private information as a space of either discrete or continuous demand states so that only the retailer knows its demand state and the demand for the product is stochastically increasing in the state. We focus on contracts that are viable in practice, where the buyback price being strictly less than the wholesale price, which is itself strictly less than the retail price. We derive the optimal (for the supplier) buyback contract that allows for arbitrary allocation of profits to the retailer (subject to the retailer’s reservation profit requirements) and show that in the limit this contract leads to the first-best solution with the supplier keeping the entire channel’s profit (after the retailer’s reservation profit). 2011 Elsevier B.V. All rights reserved.
Depressionen und Angststörungen im Peripartalzeitraum - Epidemiologie, Mutter-Kind-Beziehung und Behandlungskonzept

Postpartale psychische Erkrankungen sowie deren Folgen fur die kindliche Entwicklung finden in stationaren Behandlungseinrichtungen zunehmend Beachtung. Ca. 10 bis 15% aller Frauen entwickeln wahrend der Schwangerschaft und in der Zeit nach der Geburt eine Depression oder eine Angststorung. Postpartale psychische Storungen konnen sich nachteilig auf die Entwicklung des Kindes und den Aufbau einer stabilen Mutter-Kind-Beziehung auswirken, wobei unterschiedliche Wirkungszusammenhange diskutiert werden. Zumeist wird in der Literatur die Annahme vertreten, dass die Storungen in der Mutter-Kind-Interaktion eine Folge der psychischen Erkrankung der Mutter sind. Eine andere Sichtweise ist, dass fruhe Storungen in der Mutter-Kind-Interaktion bzw. des mutterlichen Bondings an ihr Kind selbst auslosend fur die mutterliche Erkrankung sind. Es erfolgt die Verknupfung von Untersuchungsbefunden zur fruhen Mutter-Kind-Interaktion als Bezugspunkt fur die Entwicklung spezifischer, auf die Mutter-Kind-Dyade abgestimmter Behandlungskonzepte. Eine erste Evaluation des Heidelberger Therapieangebotes der Mutter-Kind-Einheit in der Klinik fur Allgemeine Psychiatrie wird vorgestellt.
Incorporation of leucine into phospholipids of Bacteroides thetaiotaomicron

L-[4,5-3H]- or L-[U-14C]leucine was incorporated by Bacteroides thetaiotaomicron into acid-precipitable material even when the bacteria were treated with concentrations of tetracycline high enough to prevent growth. Similar results were obtained when L-[2,3,4-3H]valine or L-[4,5-3H]isoleucine was used instead of leucine. In bacteria which had been treated with tetracycline, the acid-precipitable label was not solubilized by treatment with protease, lysozyme, or deoxyribonuclease. However, virtually all of the label was extractable with chloroform-methanol, indicating that the label had been incorporated into membrane lipids. Since L-[1-14C]leucine was not incorporated into lipids, leucine was probably decarboxylated before incorporation. When a chloroform extract from bacteria which had been labeled with both [32P]phosphate and [3H]leucine was resolved into component phospholipids by two-dimensional thin-layer chromatography, 3H was incorporated into all of the phospholipids. When these phospholipids were deacylated, the 3H from leucine was associated with released fatty acids rather than with the head groups. Thus, it appears that B. thetaiotaomicron can utilize leucine and similar amino acids not only by incorporating them into protein but also by incorporating portions of these amino acids into membrane phospholipids.
The safety of human pluripotent stem cells in clinical treatment

Abstract Human pluripotent stem cells (hPSCs) have practically unlimited proliferation potential and a capability to differentiate into any cell type in the human body. Since the first derivation in 1998, they have been an attractive source of cells for regenerative medicine. Numerous ethical, technological, and regulatory complications have been hampering hPSC use in clinical applications. Human embryonic stem cells (ESCs), parthenogenetic human ESCs, human nuclear transfer ESCs, and induced pluripotent stem cells are four types of hPSCs that are different in many clinically relevant features such as propensity to epigenetic abnormalities, generation methods, and ability for development of autologous cell lines. Propensity to genetic mutations and tumorigenicity are common features of all pluripotent cells that complicate hPSC-based therapies. Several recent advances in methods of derivation, culturing, and monitoring of hPSCs have addressed many ethical concerns and technological challenges in development of clinical-grade hPSC lines. Generation of banks of such lines may be useful to minimize immune rejection of hPSC-derived allografts. In this review, we discuss different sources of hPSCs available at the moment, various safety risks associated with them, and possible solutions for successful use of hPSCs in the clinic. We also discuss ongoing clinical trials of hPSC-based treatments.
Use of Monoclonal Antibodies to Sialylated Lewisx and Sialylated Lewis 3 for Serological Tests of Cancer 1

A new monoclonal antibody, CSLEX1, directed against Sialy lated Lewis" was tested in parallel with a monoclonal antibody, CSLEA1, directed against Sialylated Lewis8 antigen. In tests with a solid-phase radioimmune sandwich assay, the Sialylated Lewis" monoclonal antibody detected sera from certain cancer patients that were negative with the Sialylated Lewis8 monoclonal anti body. Some sera from cancer patients showed the reverse reaction. We conclude that the combined use of these two monoclonal antibodies detects a wider range of sera from cancer patients than the use of a single antibody alone. It should be possible in the future to use multiple monoclonal antibodies to increase detection.
Resilience and Vulnerability to the Psychological Harm From Flooding: The Role of Social Cohesion.

OBJECTIVES We examined the role of social cohesion as a component of vulnerability and resilience to the psychological distress of flooding. METHODS A survey collected data from 2238 individuals living in flood-affected areas of England (South Yorkshire and Worcestershire) in 2007. We used Bayesian structural equation modeling to assess factors relating to the latent variables of resilience (years in area, family nearby, and social cohesion) and vulnerability (disruption of essential services, flood risk, and previous flood experience). RESULTS Flooding was strongly associated with poor mental health; however, resilience factors (associated with the ability to cope with natural disasters), but not vulnerability, were strongly associated with a reduction in psychological distress. CONCLUSIONS Resilience and social cohesion were important influences on the risk of developing poor mental health following flooding. Increasing resilience of communities by strengthening social cohesion through measures that increase civic participation and changing land use should be considered as potentially inexpensive and effective defenses against avoidable mental harm that will result from increased climate instability.
Cortical activation pattern during saccadic eye movements in humans: Localization by focal cerebral blood flow increases

Regional cerebral blood flow (rCBF) was measured in human subjects during saccadic eye movements by a 254‐channel dynamic gamma camera. Focal rCBF increases were repeatedly observed in an area within the middle precentral and premotor regions which corresponds to the frontal eye field in humans. Our findings suggest that this region is localized between the “face” and “hand” areas in the precentral gyrus and extends anteriorly out of the primary motor strip into the adjacent premotor zone. In addition, saccades were associated with focal blood flow increases in regions corresponding to the frontal supplementary motor area and to the posterior temporooccipital visual association cortex. Similar changes in patterns of rCBF occurred during contralateral and ipsilateral horizontal saccades and also during vertical saccades, and did not differ between the right and left hemispheres. Focal rCBF increases were observed in the frontal eye field during several additional test procedures including ocular fixation and visual perception of a nonmoving target, auditory stimulation with closed eyes, and reading. It is presumed that these focal flow increases reflect increased localized neuronal activity and metabolic rate and therefore permit visualization of the cortical activation pattern associated with saccadic eye movements in humans.
SPARQL queries on RDF with fuzzy constraints and preferences

With the widespread acceptance of RDF (Resource Description Framework) as the de-facto standard recommended by W3C (World Wide Web Consortium) for the representation and exchange of information on the Web, a huge amount of RDF data is being proliferated and becoming available. Efficient querying of RDF data is therefore of increasing importance. Preference queries and fuzzy queries are required for personalized queries, and have been extensively investigated in the context of databases. Focusing on SPARQL (Simple Protocol and RDF Query Language), we propose a fuzzy extension of SPARQL with preferences in this paper. First, we extend SPARQL with fuzzy sets by allowing the occurrence of fuzzy terms, fuzzy operators and fuzzy relations. Second, we introduce multi-dimensional preferences into the fuzzy SPARQL. Based on fuzzy set theory, we also propose a set of translation rules to convert the fuzzy SPARQL with preferences into crisp SPARQL. Finally we propose an effective scoring function to calculate the order of query results, which integrates the preferences and membership degrees. The proposed approach is evaluated with experiments as well.
Ultraviolet radiation exposure through window glass may be associated with localization of nonmelanoma skin cancer in organ transplant recipients: a study in France and the U.K

had failed treatment with all aluminium chloride preparations (26 female and nine male subjects; mean age 27 years, range 18–43). They had no other sites of HH, nor concurrent medications influencing their HH. Patients were counselled on application and the possible side-effect profile with a written information leaflet. Advice was given to avoid shaving the axillae and to apply 1% glycopyrrolate in Cetomacrogol cream BP, once daily (nocte), sparingly to hair-bearing skin of the axillae for 1 month. The Dermatology Life Quality Index (DLQI) was chosen in preference to hydration of stratum corneum and transepidermal water loss estimation, as we have found this method inconsistent in a previous study of patients with axillary HH. DLQI was measured before, during and after the treatment course. The glycopyrrolate preparation was tolerated well without significant irritation or other compliance-limiting factors, such as the staining of clothing. Only one patient developed significant side-effects – xerostomia and mydriasis. He was a young, large man applying the cream more liberally than advised. The side-effects resolved on reducing the strength to 0 5% glycopyrrolate in Cetomacrogol cream BP, and the amount applied. However, otherwise, only nine patients had a notable reduction in their HH (> 50% reduction in their DLQI score) and, most importantly, only two of the 35 patients wished to continue this treatment. We have been unable to demonstrate a consistent and predictable benefit from 1% Cetomacrogol Cream BP in our patients with axillary HH. Although our study is uncontrolled and our observations relate to this specific formulation of topical glycopyrrolate, we conclude its use at this site is limited by its efficacy, price (£60 for 50 g), availability and short shelf-life (3 months). In our experience it appears to be much more effective for craniofacial sites, and this may explain why most of the literature on its benefit is in diabetes or otolaryngology journals. In contrast, Botox injections (Allergan Inc., Irvine, CA, U.S.A.) for axillary HH provide a reliable and durable efficacy, and are becoming more cost-effective, particularly if the 200 iu vial is used, available to the U.K. National Health Service for £276 40.
Longstanding pain and social strain: patients’ and health care providers’ experiences with fracture management by skeletal traction; a qualitative study from Malawi

Abstract Aim: The aim of the study is to contribute to a more holistic evidence based on lower limb fracture management in low-income settings, by exploring the perspectives of those actually experiencing and administering skeletal traction in Malawi. Methods: The study took place at Queen Elizabeth Central Hospital in Blantyre and Kamuzu Central Hospital in Lilongwe, the two largest public hospitals of Malawi. Qualitative data were collected by participant observation, individual interviews with eight patients, two orthopedic surgeons, one physiotherapist, and two focus group discussions with multidisciplinary teams. Results: Patients experienced physical and psychological pain from the prolonged traction treatment in bed. Anxiety, indignity and emotional distress in the ward environment were commonly observed. Patients emphasized the negative impact on their families and the significant economic consequences due to prolonged hospitalization. Health care providers identified the major obstacles for quality treatment due to the lack of staff, equipment, specialized knowledge and skills. Rehabilitation services were nearly absent, thus little effort was made to maintain function and enhance recovery during and after long-term bed confinement. Conclusion: The use of long-term skeletal traction has a devastating impact on the patients and families, and causes major frustrations to health workers involved with fracture management in a low-resource setting. Implications for Rehabilitation As stated by various health care providers, there is a need to improve trauma care, strengthen rehabilitation services and educate more rehabilitation staff so they can take up the different roles and functions required in treatment and rehabilitation after injuries and other debilitating conditions. In the current situation, sufficient pain relief for patients is required. This should go hand in hand with the empowerment of patients so as to fulfill their rights to quality health services. For health care providers, multidisciplinary teamwork, enhanced specialized education and skills, improved access to adequate equipment and developing standardized procedures appear essential in order to improve fracture management. With injuries representing a growing portion of the global burden of disease, and in the changing demographic panorama with aging populations in Africa and the world at large, injury prevention, trauma care- and rehabilitation need a stronger focus in public health globally.
[Investigation of enterotoxin gene in clinical isolates of Staphylococcus aureus].

OBJECTIVE To detect the enterotoxin genes of Staphylococcus aureus (SA) isolated from clinical specimens and analyze the correlation between enterotoxin genes and drug resistance of SA. METHODS The mecA gene and enterotoxin genes A-F of clinical SA isolates were identified by polymerase chain reaction (PCR), and the genes were sequenced to investigate the correlation of these genes to drug resistance. RESULTS The detection rate of enterotoxin genes was 100% in 67 methicillin- resistant SA (MRSA), showing no significant difference from the rate in 57 methicillin-sensitive SA (MSSA) (83.5%, χ(2)=0.203, P>0.05). Of the 116 strains carrying enterotoxin genes (93.5%), the detection rates of SEA, SEB, SEC, SED and SEF were 90.5%, 6.9%, 61.3%, 5.2%, 25.9% and 93.5%, respectively, and none of the strains were positive for SEE gene. In these strains, 78 (67.2%) carried 2 or more enterotoxin genes, and the main genotypes were SEA and SEC (33.6%), SEA and SEF (7.8%), and SEA and SEC and SEF (13.8%). Compared with the strains carrying a single enterotoxin gene, those with multiple enterotoxin genes showed a higher drug resistance rate, among which 75% of the SA strains carrying SEA+SEC+SEF were resistant to SXT, significantly higher than the rates of SA carrying SEA (28.6%) and SEA+SEC (38.7%) (P<0.05). The SA strains carrying SEA+SEC+SEF and SEA+SEF showed significantly higher amikacin resistance rates than SA strain carrying SEA (75.0%, 77.0%, 21.5%, respectively, P<0.05). CONCLUSION Clinical isolates of SA carrying multiple enterotoxin genes have a higher drug resistance rate than those with a single enterotoxin gene, suggesting the the important role of enterotoxin in multidrug resistance.