Miracle-dz/UniFAR-FTUs huggingface dataset:
Return Migration-A Duration Analysis

Most of the economic literature on migration views the migration decision as permanent. However, several studies have shown that more and more migrants either return to their home country after a period abroad or perhaps migrate onward to a third country, see e.g. Dustmann and Weiss (2007). The economic literature on migration is therefore now becoming more differentiated, acknowledging that migration can be both a permanent and a temporary decision and that immigrants who emigrate can be both return and onward migrants. Since the duration of the migration is very important to the economic e¤ects of migration, it is crucial to obtain knowledge of the duration of the migrants stay in the receiving country. Further, it is very important to see whether there are any di¤erences between migrants with long durations compared to migrants with shorter durations. This paper will present an empirical duration analysis of migrants migrating into Denmark between 1980 to 2005. Based on data from Statistics Denmark I nd the duration time for immigrants in Denmark. I include all individuals aged 15 or above immigrated to Denmark in this period. Surely some of the immigrants have not yet left Denmark by the end of the period, so the data are right censored. I nd the hazard rate for immigrants, showing at what rate immigrants will emigrate. To analyze whether there are any di¤erences between migrants with long and short durations I nd the e¤ects on the Hazard rate from years of education, wage, tenure, unemployment, age, sex, and marital status. I expect that the duration time for immigrants with higher levels of skills will be shorter than for immigrants with lower levels of skills. There are two reasons for this. First, individuals with higher levels of education are assumed
Ramucirumab plus paclitaxel or FOLFIRI in platinum-refractory advanced or metastatic gastric or gastroesophageal junction adenocarcinoma-experience at two centres.

Background Ramucirumab is a VEGFR-2 antibody that has proven to prolong overall survival (OS) in patients with pretreated metastatic gastric/gastrooesophageal junction (GEJ) adenocarcinoma. We present data from patients treated with ramucirumab and paclitaxel or FOLFIRI after failure of at least one platinum- and 5-FU-containing chemotherapy (CHT) regimen. Methods In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy. FOLFIRI-ramucirumab (FOLFIRI-R) (n=16) was given to patients with a short interval between taxane-based perioperative CHT and occurrence of metastatic disease or to those ineligible for paclitaxel. Results The median progression-free survival (PFS) and OS for patients treated with paclitaxel-ramucirumab (pacl-R) were 2.9 (95% CI: 2.3-3.6) and 4.4 (4.1-4.7) months, respectively, and those for patients treated with FOLFIRI-R were 5.9 (95% CI: 0.35-11.4) and 8.3 (6.6-10) months, respectively (P=0.05). We observed a trend towards prolonged PFS after perioperative taxane-based FLOT CHT (n=12) with FOLFIRI-R compared with pacl-R. Adverse events were manageable, with neutropenia and polyneuropathy (PNP) being the most common events. More than two treatment lines were given to 48.2% of patients. Conclusions The use of ramucirumab in combination with FOLFIRI showed favourable PFS and OS in patients with prior treatments with platinum and/or taxane-based agents and allows further treatment lines after progression. In patients with taxane pretreatment or persistent high-grade PNP, the combination of FOLFIRI-R might be a promising combination.
Brentuximab Vedotin Monotherapy and Combined with Low Dose Donor Lymphocyte Infusion to Control Minimal Residual Disease and Sustain Clinical Remission in a Child with Relapsed Anaplastic Large Cell Lymphoma

Minimal residual disease (MRD) appears to have a strong negative predictive value for disease recurrence in children with anaplastic large cell lymphoma (ALCL). Brentuximab vedotin (BV) can be a therapeutic option for MRD-positive patients to achieve molecular remission and to decrease risk of subsequent relapse. We here report a 4-year-old child with ALCL progression during relapse treatment who received BV as a bridging therapy before haploidentical hematopoietic stem-cell transplantation, and as a maintenance therapy post-transplant alone or combined with simultaneous low dose donor-lymphocyte infusions. MRD monitoring showed a complete molecular response and reflected both BV efficiency and graft-versus-lymphoma effect.
Aluminum Surface Inclusions of Insoluble Lead Enhanced through Mechanical Attrition of Al Substrates

Preparation of aluminum substrates for surface segregation enhancement of insoluble lead deposition was achieved. Sever plastic deformation 'SPD' of Al sheets was done using surface mechanical attrition treatment 'SMAT' in air. Scanning electron microscope SEM of etched Al substrates cuts showed micro-cavities both on the surface and in-depth. Orientation effects and surface inclusions of Pb inside Al surface found at 40 and 50 Hz - SMAT Al by X-Ray diffraction and energy dispersive of X-Rays EDX. Concluding that SMAT frequency limits used enhanced surface inclusions without annealing that could improve adhesion of industrial protective Pb coatings.
Genetically encoded live cell sensor for tyrosinated microtubules

Microtubule cytoskeleton exists in various biochemical forms in different cells due to tubulin post-translational modification (PTMs). These PTMs are known to affect microtubule stability, dynamics and interaction with MAPs and motors in a specific manner, widely known as tubulin code hypothesis. At present there exist no tool that can specifically mark tubulin PTMs in live cells, thus severely limiting our understanding of tubulin PTMs. Using yeast display library, we identified a binder against terminal tyrosine of alpha tubulin, a unique PTM site. Extensive characterization validates the robustness and non-perturbing nature of our binder as tyrosination sensor, a live cell tubulin nanobody specific towards tyrosinated or unmodified microtubules. Using which, in real time we followed nocodazole, colchicine and vincristine induced depolymerization events of unmodified microtubules, and found each distinctly perturb microtubule polymer. Together, our work describes the tyrosination sensor and potential applications to study microtubule and PTM processes in living cells.
Effects of Pomegranate Concentrate Powder: Eucommiae Cortex: Achyranthis Radix 5:4:1 (w/w) Mixed Formula on Monosodium Iodoacetate-Induced Osteoarthritis in Rats

We examined the antiosteoarthritis effect of a mixture of powdered pomegranate concentrate, eucommiae cortex, and achyranthis radix (5:4:1 w/w) (PEA-Mix). After the injection of monosodium iodoacetate (MIA), PEA-Mixs were orally administered. To assess pain-related behaviors, a von Frey filament test and open field test were performed. We also examined the knee thickness, maximum knee extension angle, bone mineral density (BMD), and compressive strength of the knee joint and performed a histopathologic analysis. The number of COX-2, tumor necrosis factor (TNF)-α, poly (ADP-ribose) polymerase (PARP), and 5-bromo-2′-deoxyuridine immunoreactive cells, the prostaglandin E2 (PGE2) and 5-lipoxygenase (LPO) levels, matrix metalloproteinase (MMP) activity, and mRNA levels of chondrogenesis-related genes were analyzed. PEA-Mix significantly inhibited the MIA-induced decrease in the paw-withdrawal threshold and total distance moved, and the MIA-induced increases in the maximum knee extension angle and knee thickness. Also, the MIA-induced loss of the knee joint articular surface region and decrease in the BMD were significantly suppressed by PEA-Mix. The MIA-induced increases in the 5-LPO, PGE2, MMP-2, MMP-9, COX-2, and TNF-α mRNA levels were reduced by PEA-Mix. PEA-Mix increased the MIA-mediated reduction in the SOX-9 and aggrecan mRNA levels. The number of PARP-positive cells was smaller in PEA-Mix-administered rats than in MIA-administered rats, while the number of 5-bromo-2′-deoxyuridine-positive cells was larger. Therefore, PEA-Mix relieved the MIA-induced pain-related behaviors, chondrocyte proliferation, and anti-inflammatory activity.
Flower Infusions From Cornus mas and Cornus kousa Inhibit Aldose Reductase Enzyme, Without Any Effects on Lipotoxicity

Aldose reductase inhibitors are considered to be potential therapeutic agents for chronic diabetic complications. Diabetes mellitus can be accompanied by elevated blood levels of free fatty acids, which can cause lipotoxicity. Herbal extracts and their constituents are promising agents which have the potential for alleviating these complications. Our study was focused on the influence on these effects by flower infusions from Cornus mas L. and Cornus kousa F.Buerger ex Hance. Initially, phenolic compounds were quantified in the dried flowers. Next, we studied the ability of flower infusions from both plants to inhibit aldose reductase in vitro, the protective role in the cell model of lipotoxicity, and the cytotoxic action on fibroblast cell line NIH-3T3 by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. Both species are rich in phenolics; C. kousa flowers contain slightly higher amounts of phenolic acids (20.8%) and flavonoids (56.1%) than C. mas (20.2%) and (47.4%), respectively. Both extracts showed effective inhibition, expressed as half-maximal inhibitory concentration (IC50) (the concentration of inhibitor required to exhibit 50% inhibition of the enzyme reaction), of aldose reductase in non-toxic low concentrations (IC50 = 3.06 μg/mL for C. mas and IC50 = 2.49 μg/mL for C. kousa, respectively). In contrast, these concentrations of both extracts had almost no effects in the lipotoxicity cell model. To our knowledge, this study is the first report on C. mas and C. kousa flowers’ aldose reductase inhibitory activity and influence upon lipotoxicity.
Hydrochemical differentiation of selected reservoirs in Carpathian Mts. and Eastern European Lowland

The aim of the analysis was to compare physicochemical parameters and chemical composition of two groups of artificial reservoirs, mountain and lowland ones, characterised by different parameters and functions. Three mountain artificial reservoirs (Klimkówka, Dobczyce, Czorsztyn) located in the Upper Vistula basin (Carpathian Mountains in Poland) and three lowland reservoirs (Ivankovo, Verhnevolzhskoye, Vyshnevolotzkoye) located in the Upper Volga basin (Eastern European Lowland in Russia) were selected for the study. Data for the summer season in 2009-2013 were used in the analysis. Mountain reservoirs display high water concentrations of sulphates, chlorides and biogenic nitrates, and lower concentrations of ammonium and oxygen indicator in relation to lowland reservoirs. Similar concentrations of phosphates were noticed in both the mountain and the lowland reservoirs. The hydrochemical differentiation between the individual mountain reservoirs was small, and statistically significant differences only occurred for SEC. Greater differentiation of the hydrochemical parameters was found among the lowland reservoirs. Statistically significant differences were demonstrated with regard to SEC, Cland NO3 -.
Anomaly detection of attacks on LIDAR based automotive perception systems

—As a result of advancements in bus technology and the development of functionality related to autonomous driving the connectivity of automotive vehicles and their components inside the vehicular network is increasing. This naturally leads to an expanding attack surface and creates the demand for defense mechanisms like intrusion detection systems. An integral task of an autonomous driving vehicle is the perception of the environment, based on which the vehicle controlling functions act according to a given situation. If an attacker is able to manipulate the percieved environment of the vehicle in a controlled way he would be able to prompt a calculated reaction of the vehicles controlling functions. As machine perception systems are designed to gather speciﬁc domain-dependant information, the task of detecting anomalous behaviour of these systems is also speciﬁc to their domain. Therefore it is necessary to create a domain speciﬁc solution to detect attacks on these systems on the application level. In this paper we present a concept for detecting the manipulation of application data of LIDAR based perception systems in an automotive context, and present evaluation results of a prototype implementaion.
Driving Intervention for Returning Combat Veterans: Interim Analysis of a Randomized Controlled Trial

Date Presented 3/31/2017 Motor vehicle collisions are a leading cause of deaths for combat veterans, and effective occupational therapy driving interventions (OT–DIs) are needed. We conducted an analysis of an efficacy trial comparing an OT–DI with traffic safety education and demonstrated a reduction in driving errors for the OT–DI group. Primary Author and Speaker: Sherrilene Classen Additional Authors and Speakers: Sandra Winter Contributing Authors: Charles Levy, Abraham Yarney, Miriam Monahan
A Literature Study on the Effect of Acupuncture and Exercise on Pain and Functionality in Osteoarthritis Patients : A Literature Research

3 INTRODUCTION . 3 METHODS. 4 PARTICIPANTS. 4 SEARCHING STRATEGIES . 4 RESULTS. 4 ALL STUDIES . 4 RCT COMPARISON 1 . 5 Intervention (see Appendix1). 5 Acupuncture & Exercise & Osteoarthritis . 5 Acupuncture & Osteoarthritis . 5 SYSTEMATIC REVIEW COMPARISON 1 . 5 Intervention. 5 Exercise & Osteoarthritis . 5 RCT COMPARISON 2 . 6 Outcome measurement tools. 6 SYSTEMATIC REVIEW COMPARISON 2 . 6 Outcome measurement tools. 6 RCT COMPARISON 3 . 6 Outcome (see Appendix3). 6 SYSTEMATIC REVIEW COMPARISON 3 . 6 Outcome. 6 DISCUSSION . 6 ACKNOWLEDGEMENTS . 7 REFERENCES . 8 APPENDIX1 . 12 CHARACTERISTICS OF INCLUDED STUDIES . 12 APPENDIX2 . 18 OUTCOME MEASUREMENT TOOLS. 18 APPENDIX3 . 19 RESULT OF EACH STUDY. 19 APPENDIX4 . 24 ACUPUNCTURE POINTS, TRIGGERPOINTS & DE QI. 24
An Unusual Case of Eclampsia at 21 Weeks of Gestation with Multiple Risk Factors Except Molar Pregnancy

Preeclampsia/eclampsia is a serious complication of the pregnancy and early-onset disease is mostly associated with molar pregnancy. We present a rare case of eclampsia that occurred at very early weeks of gestation and had multiple risk factors for preeclampsia, but not molar pregnancy. A 35-year-old woman (gravidity 11, parity 1) presented with eclampsia at 21 weeks of gestation. She had history of preeclampsia in previous pregnancy, chronic hypertension, recurrent pregnancy loss (a total of 9 abortions at 6-21 weeks of gestation) and methyltetrahydrofolatereductase (MTHFR) heterozygous mutation. The pregnancy was terminated by hysterotomy. Molar change was not observed in the placenta. No postoperative complication occurred and the patient was discharged with antihypertensive therapy. Eclampsia is a severe form of the preeclampsia and clinicians should keep in mind that it may be occurred at very early weeks of gestation in patients with multiple risk factors for preeclampsia.
Executive Functions and Emotion Regulation in Attention-Deficit/Hyperactivity Disorder and Borderline Intellectual Disability

The main objective of this study is to investigate the multiple relations and to determine the differences between executive functions (EFs), emotion regulation, and behavioral and emotional problems in children with attention-deficit/hyperactivity disorder (ADHD), borderline intellectual disability (ID), and typical development (TD). The sample included 85 children aged 6 to 11 years, 42 with typical development (TD), 27 with ADHD, and 16 with borderline ID. The results emphasized a positive correlation between adaptive emotion regulation strategies and EFs, and no significant relations between the maladaptive emotion regulation strategies and EFs. In addition, the executive function of planning correlated negatively with anxiety, ADHD symptoms, and conduct problems. The performance of both clinical groups regarding EFs was significantly lower than that of the TD group, and they differed significantly from each other only on visual attention. The presence of oppositional-defiant and conduct problems was higher in both clinical groups than in the TD group, and more anxiety symptoms were reported in children with ADHD. This study supports the idea that emotion regulation, Efs, and clinical symptoms are interconnected. It also profiles the deficits in cognitive functioning and emotion regulation in two clinical groups, thus helping future intervention programs.
Syntactic Comprehension of Relative Clauses and Center Embedding Using Pseudowords

Relative clause (RC) formation and center embedding (CE) are two primary syntactic operations fundamental for creating and understanding complex sentences. Ample evidence from previous cross-linguistic studies has revealed several similarities and differences between RC and CE. However, it is not easy to investigate the effect of pure syntactic constraints for RC and CE without the interference of semantic and pragmatic interactions. Here, we show how readers process CE and RC using a self-paced reading task in Korean. More interestingly, we adopted a novel self-paced pseudoword reading task to exploit syntactic operations of the RC and CE, eliminating the semantic and pragmatic interference in sentence comprehension. Our results showed that the main effects of RC and CE conform to previous studies. Furthermore, we found a facilitation effect of sentence comprehension when we combined an RC and CE in a complex sentence. Our study provides a valuable insight into how the purely syntactic processing of RC and CE assists comprehension of complex sentences.
Identification of Mosquito Bloodmeals Collected in Diverse Habitats in Malaysian Borneo Using COI Barcoding

Land cover and land use change (LCLUC) acts as a catalyst for spillover of arthropod-borne pathogens into novel hosts by shifting host and vector diversity, abundance, and distribution, ultimately reshaping host–vector interactions. Identification of bloodmeals from wild-caught mosquitoes provides insight into host utilization of particular species in particular land cover types, and hence their potential role in pathogen maintenance and spillover. Here, we collected 134 blood-engorged mosquitoes comprising 10 taxa across 9 land cover types in Sarawak, Malaysian Borneo, a region experiencing intense LCLUC and concomitant spillover of arthropod-borne pathogens. Host sources of blood were successfully identified for 116 (87%) mosquitoes using cytochrome oxidase subunit I (COI) barcoding. A diverse range of hosts were identified, including reptiles, amphibians, birds, and mammals. Sixteen engorged Aedes albopictus, a major vector of dengue virus, were collected from seven land cover types and found to feed exclusively on humans (73%) and boar (27%). Culex tritaeniohynchus (n = 2), Cx. gelidus (n = 3), and Cx. quiquefasciatus (n = 3), vectors of Japanese encephalitis virus, fed on humans and pigs in the rural built-up land cover, creating potential transmission networks between these species. Our data support the use of COI barcoding to characterize mosquito–host networks in a biodiversity hotspot.
“Narcan Encounters:” Overdose and Naloxone Rescue Experiences among People who Use Opioids

Background Communities across the United States are confronting the precipitous rise in opioid overdose fatalities that has occurred over the past decade. Naloxone, an opioid antagonist, is a safe rescue medication that laypeople can administer to reverse an overdose. Community naloxone training programs have been well-documented. Less is known about overdose survivors’ subjective experiences with naloxone reversal and its impacts on drug use behavior. Methods Semi-structured interviews were conducted with 35 community-dwelling adults who had been reversed at least once with naloxone. Inductive thematic content analysis incorporating Atlas.ti software was used to identify themes. Results Four broad thematic categories were identified. (1) Overdose experience and memory: Most participants remembered taking the drugs one minute and waking up the next—sometimes in different surroundings; (2) Naloxone rescue—waking up: Participants described acute withdrawal symptoms, disorientation, and volatile emotions; (3) Reasons for overdose: Polypharmacy; changes in opioid tolerance, or presence of fentanyl were the most common explanations. (4) Impacts of naloxone rescue: A variety of contextual factors influenced participants’ responses to naloxone rescue, especially acute withdrawal symptoms. While some participants altered or tempered their opioid use, others resumed opioid use—especially to mitigate withdrawal. Participants overwhelmingly emphasized that naloxone saved their lives. Conclusion Results suggest that a naloxone rescue may not be a wake-up call for many people who use opioids, but access to naloxone is an effective overdose harm reduction option, supporting its widespread implementation. The study findings underscore the importance of ongoing community overdose prevention and harm reduction initiatives, including take-home naloxone (THN) and medication assisted treatment in the Emergency Department.
Association Between the Cerebral Autoregulation Index (Pressure Reactivity), Patient’s Clinical Outcome, and Quality of ABP(t) and ICP(t) Signals for CA Monitoring

Background and Objectives: The aim of this study was to explore the association between the cerebral autoregulation (CA) index, the pressure reactivity index (PRx), the patient’s clinical outcome, and the quality of arterial blood pressure (ABP(t)) and intracranial blood pressure (ICP(t)) signals by comparing two filtering methods to derive the PRx. Materials and Methods: Data from 60 traumatic brain injury (TBI) patients were collected. Moving averaging and FIR (Finite Impulse Response) filtering were performed on the ABP(t) and ICP(t) signals, and the PRx was estimated from both filtered datasets. Sensitivity, specificity, and receiver-operating characteristic (ROC) curves with the area under the curves (AUCs) were determined using patient outcomes as a reference. The outcome chosen for comparison among the two filtering methods were mortality and survival. Results: The FIR filtering approach, compared with clinical outcome, had a sensitivity of 70%, a specificity of 81%, and a level of significance p = 0.001 with an area under the curve (AUC) of 0.78. The moving average filtering method compared with the clinical outcome had a sensitivity of 58%, a specificity of 72%, and a level of significance p = 0.054, with an area under the curve (AUC) of 0.66. Conclusions: The FIR (optimal) filtering approach was found to be more sensitive for discriminating between two clinical outcomes, namely intact (survival) and impaired (death) cerebral autoregulation for TBI treatment decision making.