Miracle-dz/UniFAR-FTUs huggingface dataset:
A Brief Survey for MicroRNA Precursor Identification Using Machine Learning Methods

MicroRNAs, a group of short non-coding RNA molecules, could regulate gene expression. Many diseases are associated with abnormal expression of miRNAs. Therefore, accurate identification of miRNA precursors is necessary. In the past 10 years, experimental methods, comparative genomics methods, and artificial intelligence methods have been used to identify pre-miRNAs. However, experimental methods and comparative genomics methods have their disadvantages, such as time-consuming. In contrast, machine learning-based method is a better choice. Therefore, the review summarizes the current advances in pre-miRNA recognition based on computational methods, including the construction of benchmark datasets, feature extraction methods, prediction algorithms, and the results of the models. And we also provide valid information about the predictors currently available. Finally, we give the future perspectives on the identification of pre-miRNAs. The review provides scholars with a whole background of pre-miRNA identification by using machine learning methods, which can help researchers have a clear understanding of progress of the research in this field.
Prediction of performance by non-cognitive traits

ABSTRACT Project A clearly demonstrated that performance is multidimensional and that some aspects are better predicted by noncognitive measures. Substantial research and development in the ensuing years has focused on personality and vocational interests. The articles in this special issue convincingly demonstrate that at least one personality measure developed by military researchers, the Tailored Adaptive Personality Assessment System (TAPAS), is resistant to faking, which was an important concern about earlier single statement instruments. Moreover, several articles report showing that TAPAS predicts retention and important aspects of “will do” performance. On the other hand, these papers show that TAPAS adds little or no incremental validity to “can do” aspects of performance over and above the Armed Services Vocational Aptitude Battery (ASVAB). Three measures of vocational interest are described in articles in this special issue and research has been positive about their ability to predict attrition, rates of promotion and reenlistment, and job satisfaction. A number of topics for further research are noted.
Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication

While animals navigating the real world face a barrage of sensory input, their brains evolved to perceptually compress multidimensional information by selectively extracting the features relevant for survival. Notably, communication signals supporting social interactions in several mammalian species consist of acoustically complex sequences of vocalizations. However, little is known about what information listeners extract from such time-varying sensory streams. Here, we utilize female mice’s natural behavioural response to male courtship songs to identify the relevant acoustic dimensions used in their social decisions. We found that females were highly sensitive to disruptions of song temporal regularity, and preferentially approached playbacks of intact over rhythmically irregular versions of male songs. In contrast, female behaviour was invariant to manipulations affecting the songs’ sequential organization, or the spectro-temporal structure of individual syllables. The results reveal temporal regularity as a key acoustic cue extracted by mammalian listeners from complex vocal sequences during goal-directed social behaviour.
Assessment of Smartphone Addiction among Undergraduate Students of Sumandeep Vidyapeeth, Vadodara

The study was conducted for Assessment of Smartphone Addiction among Undergraduate Students of Sumandeep Vidyapeeth, Vadodara. The study was conducted at the selected departments of Sumandeep Vidyapeeth like nursing department, pharmacy department, physiotherapy department, dental department and MBBS department. The sample size is 200 undergraduate students, from selected departments of Sumandeep Vidyapeeth who fulfill the inclusive criteria. Non probability, quota sampling technique technique was used. The research tool was developed in English. Modified Smartphone addiction scale (Self-structured checklist) will be used for the assessment of smartphone addiction among Undergraduate Students of Sumandeep Vidyapeeth Vadodara. The finding show that level of smart phone addiction among undergraduate students of Sumandeep Vidyapeeth is 1.0% are strongly addicted, 31.5% are moderately addicted, and 61.0% are less addicted, 6.5% have No addiction. The association between smart phone addictions and selected socio demographic variables was done by Chi Square formula. There is no significant association between smart phone addiction score and selected demographic variables with 0.05 level of significant except age in years and how frequently you use your smartphone of sample's P calculated value is greater than 0.05 level of significance.
Imagination exercises improve language in younger but not in older children with autism suggesting a strong critical period

Based on a few cases of childhood traumatic aphasia and hemispherectomy, Lenneberg suggested a critical period for first language acquisition. Lenneberg's ideas are still debated today and have never been tested in a large group of children. Autism Spectrum Disorder (ASD) provides such an opportunity as language acquisition is a common problem in ASD. Here, we report data from a three-year-long observational trial of 8,766 children with ASD. We initiated this trial in order to test two hypotheses: 1) voluntary imagination is central to complex language and 2) there exists a strong critical period for voluntary imagination acquisition closing shortly after the age of 5. Accordingly, we developed imagination exercises (verbal and nonverbal), organized them into an application called Mental Imagery Therapy for Autism (MITA) and provided this MITA app gratis to children ages 2 to 12. MITA-experienced children (N=3,540) were matched to the 'treatment-as-usual' participants (TaU, N=5,226). Both younger (2-5 years of age) and older children (5-12 YOA) in MITA and TaU groups improved their language over time, but on an annualized basis, younger MITA children improved their language 3-fold faster than TaU group. There was no difference between MITA and TaU in the older children group. These findings support Lenneberg's critical period hypothesis and indicate that acquisition of voluntary imagination is essential for the full language acquisition. Crucially, our results imply that the underlying plasticity dramatically diminishes after the age of five and therefore even greater therapeutic intervention should be targeting the very first years of a child's life. Clinical Trial Registration ID #NCT02708290.
A 7.8 Gb/s/pin, 1.96 pJ/b Transceiver With Phase-Difference-Modulation Signaling for Highly Reflective Interconnects

This paper presents a phase-difference-modulation transceiver with simple clock recovery for highly-reflective interconnects. By greatly suppressing reflective intersymbol interferences with two new enabling mechanisms, phase–difference modulation enables high-speed data communication through highly-reflective multi-drop channels without utilizing decision feedback equalization. A systematic analytical approach is presented, and provides guidelines on how to determine channel and signaling parameters to exploit the two enabling mechanisms based on a newly derived formula of a single bit response of a channel. In addition, we propose a phase-difference amplifier that relieves the timing constraint of the bit decision at the receiver. By deserializing the received signals using the clock embedded in the received signals, the phase-difference amplifier can greatly reduce the design complexity of the clock recovery circuit. The proposed transceiver was fabricated in 65-nm CMOS technology. In single-ended mode, the transceiver achieved a maximum speed of 7.8 Gb/s/pin at energy cost of only 1.96 pJ/b while overcoming 10 in-band notches without decision feedback equalization. Also, the phase-difference amplifier enables clock recovery at power and area costs of only 0.12 pJ/b and 550 $\mu \text{m}^{2}$ , respectively, in single-ended 6-Gb/s/pin operation.
Hierarchical Knowledge Squeezed Adversarial Network Compression

Deep network compression has been achieved notable progress via knowledge distillation, where a teacher-student learning manner is adopted by using predetermined loss. Recently, more focuses have been transferred to employ the adversarial training to minimize the discrepancy between distributions of output from two networks. However, they always emphasize on result-oriented learning while neglecting the scheme of process-oriented learning, leading to the loss of rich information contained in the whole network pipeline. Whereas in other (non GAN-based) process-oriented meth-ods, the knowledge have usually been transferred in a redundant manner. Observing that, the small network can not perfectly mimic a large one due to the huge gap of network scale, we propose a knowledge transfer method, involving effective intermediate supervision, under the adversarial training framework to learn the student network. Different from the other intermediate supervision methods, we design the knowledge representation in a compact form by introducing a task-driven attention mechanism. Meanwhile, to improve the representation capability of the attention-based method, a hierarchical structure is utilized so that powerful but highly squeezed knowledge is realized and the knowledge from teacher network could accommodate the size of student network. Extensive experimental results on three typical benchmark datasets, i.e., CIFAR-10, CIFAR-100, and ImageNet, demonstrate that our method achieves highly superior performances against state-of-the-art
EFFECTS OF CARDIOPULMONARY CONDITIONING ON BODY MASS INDEX, PHYSICAL ACTIVITY AND GENERAL PSYCHOLOGICAL HEALTH OF YOUNG ADULTS

Objective: To determine the effects of cardiopulmonary conditioning on bodymass index (BMI), physical activity (PA), and general psychological health ofhealthy young adults and their interrelationship. Methodology: A quasi-interventional study was conducted in Pakistan RailwayHospital, Rawalpindi from February to July 2017. A total of 97 healthy youngadults who sustained moderate physical exertion were selected through nonprobabilityconvenient sampling to perform cardiopulmonary conditioningexercises for 12 weeks at moderate intensity. Individuals with any systemicdisease were excluded. The pre and post levels of PA, general psychologicalhealth and BMI were assessed through International Physical ActivityQuestionnaire (IPAQ), General Health Questionnaire (GHQ-12) and BMI formularespectively and performed statistical analysis on SPSS 20 software.Results: We recruited 97 participants; mean age was 23.40 ± 2.29years. Majority, around 74% of the participants were females. The descriptive analysisshowed that 73.2 % participants were minimally active before the interventionthat improved to 0.0 % after the intervention. No participant was HEPA activebefore intervention that significantly improved to 38.1 %. In the pre-intervention,87.6 % participants were overweight and 12.4 % participants were obese whereas in post-intervention, 85.6 % participants had normal weight and 14.4 %participants were overweight. The Wilcoxon Signed Rank Test revealedsignificant improvement in all outcome measures (p= 0.001). The Spearman'sCorrelations of PA and general psychological health and PA and BMI wasdemonstrated as -0.262 (p=0.01) and -0.081 (p=0.431) respectively. Conclusion: Cardiopulmonary conditioning is an effective approach forimproving BMI, general psychological health and physical activity. With higherlevels of PA general psychological health improves unlike BMI that does not haveany significant relation with PA.
Model-based clustering with envelopes

: Clustering analysis is an important unsupervised learning technique in multivariate statistics and machine learning. In this paper, we pro-pose a set of new mixture models called CLEMM (in short for Clustering with Envelope Mixture Models) that is based on the widely used Gaussian mixture model assumptions and the nascent research area of envelope methodology. Formulated mostly for regression models, envelope methodology aims for simultaneous dimension reduction and eﬃcient parameter estimation, and includes a very recent formulation of envelope discriminant subspace for classiﬁcation and discriminant analysis. Motivated by the envelope discriminant subspace pursuit in classiﬁcation, we consider parsimonious probabilistic mixture models where the cluster analysis can be improved by projecting the data onto a latent lower-dimensional subspace. The proposed CLEMM framework and the associated envelope-EM algorithms thus provide foundations for envelope methods in unsupervised and semi-supervised learning problems. Numerical studies on simulated data and two benchmark data sets show signiﬁcant improvement of our propose methods over the classical methods such as Gaussian mixture models, K-means and hierarchical clustering algorithms. An R package is available at https://github.com/kusakehan/CLEMM .
Thyroid function tests in polycystic ovarian syndrome

Background: Polycystic ovarian syndrome (PCOS) or polycystic ovarian disease (PCOD) is the most common endocrine problem in young females with chronic anovulatory cycles occurring in 5-10% of reproductive women. PCOS is viewed as a heterogeneous disorder of multifactorial etiology also associated with increased metabolic and cardiovascular risk factors. Both PCOD and thyroid dysfunction have multiple common presentations and both have profound effect on fertility and reproductive biology. Hypothyroidism can initiate, maintain or worsen PCOD. Aims and Objectives: This study has been contemplated to investigate the prevalence of thyroid disorders in PCOS patients from Central India. Materials and Methods: Female patients in the age group between 18 and 30 years meeting Rotterdam criteria for the diagnosis of PCOS were included in the study. The patients were asked to report in fasting state for the following investigations: Fasting blood sugars, fasting insulin levels, serum luteinizing hormone (LH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), serum testosterone, dehydroepiandrosterone, and serum prolactin were done. FSH and LH were done on the 2nd or 3rd day of menstrual cycle. Gynecological ultrasound was done to assess ovarian condition and presence or absence of multiple cysts. Results: LH/FSH ratio of more than 2 was found in 60% of the cases, 41 subjects (68%) were insulin resistant. Raised serum testosterone was found in 64% of the cases. The mean TSH level in subjects was 4.219333 ± 1.877632. Subclinical hypothyroidism was seen in 16 (26.6%) cases and overt hypothyroidism in 12 (20%) cases. Total thyroid dysfunction (clinical and subclinical) was seen in 28 (46.66%) cases. Conclusion: The prevalence of thyroid dysfunction in PCOS is very high. All patients with PCOS should be screened for thyroid dysfunction.
Design and realization of novel frequency selective surface loaded dielectric resonator antenna via 3D printing technology

One frequently addressed technique for the performance enhancement of radiating elements in the form of microstrip antennas is the utilization of dielectric resonators. A dielectric resonator antenna (DRA) has a conventional structural formation similar to any microstrip patch antenna where, at least, one additional dielectric layer has been placed over the radiating element. In this paper, it is aimed to propose a high performance, easy to prototype, light weight, and low cost DRA in combination with frequency selective surfaces (FSS) for ISM band applications using 3D printing technology. The proposed 3D printed FSS loaded DRA has a measured gain of 5.6 dBi with S11 level less than −10 dB in the operation band between 1.98 and 2.68 GHz. Furthermore, the measured performance of 3D printed antenna is compared with the counterpart alternative antenna designs in the literature for the similar application fields. The novel FSS loaded DRA is not only much smaller than the counterpart antenna designs but also has a moderate gain characteristics which makes the proposed antenna design an optimal RF solution for ISM band wireless communication applications.
Flow Resistance and Energy Dissipation in Supercritical Air‐Water Flows Down Vegetated Chutes

Vegetation covers on dikes and embankment dams have proven as sustainable and cost‐effective surface protection against external erosion caused by hydraulic, mechanical, or climatic impacts. Determination of the hydraulic loads that act upon these covers requires the knowledge of the flow resistance. While the high‐velocity flows on vegetated slopes are often aerated, the flow aeration has rarely been considered, and no direct measurements of the air‐water flow properties have been conducted to date. The air‐water flow properties are needed for a direct estimation of important design parameters such as friction factors and residual head at the downstream end. Herein, unique air‐water flow measurements were conducted in high‐velocity air‐water flows down a vegetated chute with a 1:3 slope. Several vegetation covers were tested for a range of flow rates. The experiments revealed strong flow aeration within three‐dimensional, fragmented flows associated with complex interactions of vegetation and high‐velocity flows. The air‐water flow properties were measured with phase‐detection intrusive probes providing novel insights into aerated flows on vegetated chutes including distributions of void fraction, bubble count rate, and interfacial velocity as well as direct estimates of energy dissipation and flow resistance. The results highlighted strong flow aeration and energy dissipation for all vegetated configurations. The median equivalent Darcy‐Weisbach friction factors for all vegetations were within 0.19 to 0.45, comparable to aerated flows on stepped spillways. The present results highlighted the significant flow resistance of vegetated covers and the need to consider air‐water flow properties in the design of vegetated chutes.
Iron, Folate and Vitamin B12 Status of Children and Adolescents: Single Center Study in the Aegean Region

Objective: Although anemia is frequently seen in children, there isn’t adequate number of study related with this issue. In this study, we aimed to investigate iron, folate and vitamin B12 status in children and adolescents in a single center in the Aegean region of our country. Method: We retrospectively evaluated the children without chronic disease who were admitted to our hospital between 2008-2016 (n=7310). Ferritin, iron and iron binding capacity were measured by Olympus 2700 analyzer. Folate and vitamin B12 were measured using Immulite 2000 and Cobas E411 analyzer, respectively. MCV and hemoglobin were measured with Beckman Coulter LH750. Kruskal-Wallis and Mann-Whitney U tests were used for comparison between groups. Results: Children (2743 boys, and 4567 girls) aged between 1-18 years old were screened. The percentage of iron, folate, vitamin B12 and combined iron and vitamin B12 deficiencies were found to be 21.7%, 8%, 16.9%, and 4.7% respectively, while 18.8% of all children were in the anemic group. The incidence of combined iron and vitamin B12 in anemic group was found to be high (10.2%), although anemic and nonanemic groups were similar with respect to vitamin B12 and folate deficiencies. Conclusion: Iron deficiency may mask the megaloblastic anemia caused by vitamin B12 and folate deficiency. Effective preventive social nutrition programs may be useful in preventing anemia.
Antitumor effects of dabrafenib, trametinib, and panitumumab as single agents and in combination in BRAF-mutant colorectal carcinoma (CRC) models.

3513 Background: In contrast to BRAF-mutant melanoma, the inhibition of BRAF or BRAF/MEK has been relatively ineffective in the treatment of BRAF-mutant CRC, possibly due to EGFR-dependent resistance mechanisms. This study aimed to determine the anti-tumor activities for BRAF/MEK inhibition with or without EGFR inhibition in BRAFV600E CRC models and to identify biomarkers of response/resistance. Methods: We assessed cell growth inhibition, apoptosis and cell signaling changes by inhibitors of BRAF (dabrafenib, D), MEK (trametinib, T), and EGFR (panitumumab, P, cetuximab, and erlotinib) dosed as monotherapies and in combination in five BRAFV600E human CRC lines (Colo205, HT29, RKO, SW1417 and LS411N). Further, these inhibitors were evaluated for their anti-tumor effects either alone or in combination in two BRAFV600E CRC patient derived tumor xenografts (PDXs) established in female nude mice. One patient-derived xenograft (PDX) harbored the PIK3CAH1047R mutation (Co-018) and the other (Co-012) was wildtype.
Efektivitas Program Duta Hand Hygiene di Rumah Sakit Islam Jemursari Surabaya

Latar Belakang: Infeksi terkait pelayanan kesehatan dapat mempengaruhi keselamatan pasien, petugas kesehatan dan pengunjung di pelayanan kesehatan termasuk rumah sakit. Rumah Sakit Islam Jemursari Surabaya melaksanakan program Duta Hand Hygiene salah satu tujuannya yaitu untuk meningkatkan kepatuhan hand hygiene petugas rumah sakit. Tujuan: Tujuan penelitian ini untuk mengetahui efektivitas dengan menguji pengaruh pelaksanaan program Duta Hand Hygiene terhadap kepatuhan five moment hand hygiene petugas dan menjelaskan strategi promosi kesehatan berdasarkan startegi multimodal WHO dalam peningkatan hand hygiene di rumah sakit. Metode: Penelitian ini dilakukan di Rumah Sakit Islam Jemursari dengan metode pengumpulan data sekunder dari laporan bulanan Komite Pencegahan dan Pengendalian Infeksi terkait monitoring kepatuhan hand hygiene, wawancara dan observasi. Teknik analisa data yang digunakan yaitu kuantitatif yang diuji menggunakan uji-T berpasangan. Hasil: Kepatuhan five moment hand hygiene petugas meningkat setelah diberlakukannya program duta hand hygiene di rumah sakit. Berdasarkan hasil uji statisktik yaitu uji-T berpasangan didapat bahwa terdapat perbedaan yang signifikan kepatuhan hand hygiene petugas pada momen dua sampai momen lima dan hasil uji statistik secara keseluruhan menunjukan hasil yang signifikan sebesar 0.000001 . Hasil penelitian ini menunjukkan ada perbedaan kepatuhan sebelum dilaksanakan program Duta Hand Hygiene dan selama program Duta hand hygiene berlangsung. Kesimpulan: Program ini efektif dilakukan serta pelaksanaannya didukung oleh strategi multimodal WHO untuk peningkatan praktik hand hygiene antara lain perubahan sistem, pelatihan atau edukasi, evaluasi dan umpan balik, pengingat di tempat kerja dan iklim institusional yang aman.
Switching controls for linear stochastic differential systems

We analyze the exact controllability problem of switching controls for stochastic control systems endowed with different actuators. The goal is to control the dynamics of the system by switching from an actuator to the other such that, in each instant of time, there are as few active actuators as possible. We prove that, under suitable rank conditions, switching control strategies exist and can be built in a systematic way. The proof is based on building a new functional by the adjoint system whose minimizers are the switching controls.