Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomarker driven phase II umbrella trial study of AZD1775, AZD2014, AZD2811 monotherapy in relapsed small cell lung cancer.

8514 Background: Recent progress in genomic profiling of small cell lung cancer (SCLC) has demonstrated that a high proportion of SCLC harbor mutations in cell cycle-related genes and RICTOR amplification. With the recent introduction of cell-cycle altering small molecules, AZD1775 (WEE1 inhibitor), AZD2811 (aurora kinase B inhibitor) and mTOR1/2 inhibitor (AZD2014), biomarker-driven umbrella study is being conducted in relapsed SCLC. Methods: This is a phase II umbrella trial study with multiple monotherapy arms in resistant SCLC who has failed prior platinum-based chemotherapy and known genomic profile from pre-designed screening study of SUKSES-S (Small cell lung cancer Umbrella Korea StudiES, NCT02688894). Patients with MYC family amplification or co-alteration in CDKN2A and TP53 were allocated to SUKSES-C (AZD1775 arm, NCT02593019); RICTOR amplification to SUKSES-D (AZD2014 arm, NCT03106155). Otherwise, patients were randomly assigned to non-biomarker specific arms, SUKSES-N1 (AZD1775 arm, NCT02593019) or SUKSES-N3 (AZD2811 arm, NCT03366675). Each cohort was designed as Simon 2-stage scheme. Results: Patients allocated to SUKSES-C (n = 7) & N1 (n = 24) showed no objective response rate and stable disease was observed in 3 patients (42.9%) and 6 patients (25.0%), respectively. The median progression-free survival (PFS) was 1.28 months (95% confidential interval [CI] 1.18–not available [NA]) and 1.21 months (95%CI 1.15-2.33), respectively. SUKSES-D (n = 4) showed no objective response as well as no stable disease with PFS of 1.25 months (95%CI 0.98-NA). SUKSES-N3 (n = 15) showed no objective response with 5 stable disease (33.3%) and PFS of 1.61 months (95%CI 1.18-NA). For the safety record, adverse events (AEs) grade≥3 were observed as follows: SUKSES-C & -N1 (n = 1, 3.2%), -D (n = 3, 75.0%), -N3 (n = 9, 60%). Notably, neutropenia (grade≥3) was frequently observed (n = 8, 53.3%) in AZD2811 arm including a case of septic shock. Conclusions: SUKSES is the first biomarker-driven umbrella study with the largest cohort of genomic profile pre-screened in resistant SCLC patients (n = 275). However, it does not support further development of the current regimens of AZD1775, AZD2811, AZD2014. Altered administration schedule or combination regimen is under development. Clinical trial information: NCT02593019, NCT03106155, NCT03366675.
Bile Duct Cancer: Preoperative Evaluation and Management

Cholangiocarcinomas (CCAs) are malignant tumors that can develop anywhere along the biliary tree. Almost 10% of cholangiocarcinomas arise from the intrahepatic bile ducts (iCCA); 50–60% from the bifurcation of the hepatic duct (perhilar cholangiocarcinoma, pCCA); and 20–30% from the distal bile duct (dCCA). The 7th edition of the AJCC staging system, released in 2010, divides the tumors into two major categories: perihilar (pCCA) and distal (dCCA) cholangiocarcinoma, given the differences in anatomy of the bile duct and consideration of local factors related to resectability. There are separate histological classifications for intrahepatic and extrahepatic cholangiocarcinoma. The majority of CCAs (90%) are well or moderately differentiated adenocarcinomas. Other features include invasiveness with early neural, perineural, periductal and lymphatic infiltration (more than 50% of cases at diagnosis) and longitudinal subepithelial infiltration along the wall of the bile duct up to 2 cm proximally and 1 cm distally. In this chapter the extrhepatic bile duct cancers are analyzed.
Presenteísmo e sintomas musculoesqueléticos entre trabalhadores de enfermagem

Objetivo: identificar la prevalencia de sintomas musculoesqueleticos en dos etapas (antes y despues de seis meses de la primera etapa) y su asociacion con el presentismo entre trabajadores de enfermeria. Metodo: estudio longitudinal con abordaje cuantitativo de los datos, realizado en un hospital brasileno de ensenanza, entre 211 trabajadores de enfermeria. Los instrumentos utilizados para la colecta de datos fueron: el cuestionario Cultural and Psychosocial Influences on Disability - CUPID, para identificar los sintomas musculoesqueleticos y la Escala Stanford Presenteeism, para comprobar el presentismo. Los respectivos instrumentos se validaron al portugues brasileno. El comite de etica de investigacion cientifica con seres humanos aprobo el estudio. Se utilizo la estadistica descriptiva para el analisis de los datos, la prueba de Mann Whitney y el analisis de regresion. Resultados: 158 (74,9%) trabajadores demostraban presentismo y 151 (71,6%) se refirieron al dolor lumbar como sintoma musculoesqueletico. Los trabajadores con dolor lumbar presentaban puntuacion menor en la escala del presentismo y el dolor en el hombro estaba relacionado con la perdida de concentracion durante el trabajo. Conclusion: el presentismo ocasiono reduccion en el desempeno del trabajo, se manifesto en la presencia de los sintomas musculoesqueleticos y el dolor en el hombro causo perdida de concentracion en el trabajo.
Wooden Breast in Commercial Broilers Associated with Mortality, Dorsal Recumbency, and Pulmonary Disease

SUMMARY. Occurrence of mortality, wooden breast, and pulmonary disease in broiler chickens during the last 16 days of production in a teaching flock of 4000 commercial broilers was determined. A new syndrome was identified, in which broilers fell over for an unknown reason and were unable to right themselves (dorsal recumbency). Birds affected by dorsal recumbency were alert and responsive and showed no clinical signs except for occasional mild to moderate dyspnea. When turned over, they resumed normal behavior. Mortality (14 culls; 49 dead) during the last 16 days of production accounted for 1.6% of the flock and 36% of total mortality. Among these, 71% were heavy males, 70% had wooden breast, and 71% had pulmonary congestion and edema. Gross lesions of concurrent wooden breast and pulmonary disease occurred in 68% of the mortality, including 21 of 22 dead birds found on their backs. These findings indicate that wooden breast is associated with mortality prior to processing as a result of pulmonary disease in heavy male broilers. When birds with wooden breast fall onto their backs for unknown reason(s), they are unable to right themselves. If not found and turned over, they may not survive. Based on these findings, wooden breast is likely greater than just a problem with meat quality and should be considered an animal well-being issue.
Compositionality and competition in monkey alert calls

In their paper, Schlenker et al. (2016b) analyse a wealth of data on monkey alert calls using the tools of formal semantics and pragmatics. Such a pursuit promises to be extremely valuable. By figuring out exactly how such animal communication systems work, we may be able to shed light on evolutionary precursors of human language. While the field is too nascent to say anything concrete on this front, the paper hopes to show the promise of using these methods. In my comments, I want to carefully examine whether the methods are in fact appropriate and what justifies their use. First, I will briefly review scalar implicatures because a similarmechanism plays a critical role in all of their case studies. Then, I will closely look at two of the case studies and raise some questions in each case about the theoretical roles that sentences and compositional interpretation thereof play. Finally, I will conclude with some general worries about the use of competition among alert calls to account for the data at hand.
Efficient Router for MPSoC Communication

Moore’s law fashioned a major revolution in semiconductor industry which is the System-on-chip (SoC). Multiple independent circuit implementations are integrated into a single chip in SoC. The applications which require more number of processors leads to the development of Multiprocessor System on Chip (MPSoC). The MPSoC design is having their own share of issues and challenges. The ever increasing complexity in modern MPSoC designs makes challenges to the design engineers. The communication between different IP cores is one of the major problems faced by MPSoC. This works presents an efficient FSM and FIFO base router design for MPSoC communication. The design functional verification and synthesis is done by using Xilinx-ISE. The obtained results matching with expected ones show that this will be an efficient solution for the communication field.
AEROBIC TRAINING AND THE CHANGES ON THE SERUM LEVELS OF SEROTONIN AND IN THE SYMPTOMS OF DEPRESSION IN ELDERLY WOMEN

Abstarct. This study investigated the effects of an 8-wk aerobic training program on the serum levels of serotonin and in the changes in the symptoms of depression in elderly women. The sample of this study was divided in two groups: experimental (n=28) and control (n=20), with 58.66.4 and 56.85.1 years old respectively. The serum levels of serontonin were significantly reduced (p<0.05) in the experimental group when compared to the control group. A significant improve (p<0.05) in the symptoms of depression was also observed. This study demonstrated that 8-wk with 5 d.wk -1 of moderate and progressive aerobic training emphasizing walking can safely cause significant reduction in the serum levels of serontonin and improve the symptoms of depression in elderly women. (Biol.Sport 24:255-264, 2007)
Class AB CMOS amplifiers with high efficiency

A new class AB CMOS operational-amplifier principle is presented. A transconductance amplifier based on this principle exhibits small-signal characteristics comparable to those of a conventional OTA. It has, however, a superior current efficiency and its settling time is not slew-rate limited. The new class AB principle can also be used in an output stage with a well-defined quiescent current, a rail-to-rail output swing, and a good driving capability. A two-stage amplifier with both the input and output stages based on the new principle has been realized. It features a rail-to-rail input and output common-mode range, a gain-bandwidth of 370-kHz, a settling time of less than 5 mu s independent of the applied step, and a power consumption of 247 mu W. It drives a resistive load of 3 k Omega in parallel with a capacitive load of 400 pF when operated on a 2.5-V/-2.5-V power supply. >
Tolerance of Soybean Cultivars to Weed Competition and Herbicides

The competitiveness of 10 soybean [Glycine max (L.) Merr. ] cultivars to weeds, their tolerance to twice normal rates of commonly used soybean herbicides, and the soil residual properties of these herbicides were studied during 4 years at Lincoln, Nebraska. Three soybean cultivars showing the least percentage yield loss from weeds were ‘Harosoy 63′, ‘Amsoy’, and ‘Corsoy’; whereas cultivars showing the greatest yield loss were ‘Hawkeye 63′, ‘Shelby’, and ‘Lindarin 63′. The two herbicide treatments causing the greatest average soybean yield loss were 3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea (linuron) at 4.5 kg/ha and α,α,α-trifluro-2,6-dinitro-N,N-dipropyl-p-toluidine (trifluralin) at 2.2 kg/ha. Cultivar selection was important in reducing soybean yield loss from herbicides as linuron at 4.5 kg/ha reduced yields 5% for ‘Harosoy 63’ to as much as 31% for ‘Ford’. ‘Neal’ oat (Avena saliva L.) yields showed 4-(methylsulfonyl)-2,6-dinitro-N,N-dipropylaniline (nitralin) to be the most persistent herbicide in soil in this study followed by trifluralin. Plowing the soil eliminated the phytotoxicity of nitralin and trifluralin to subsequently planted oats.
Benefits of the clinical pilates program in lower back pain in young handball players

Introduction: Handball is one of most associated sports with low back injuries. Low back pain is one of the main reasons for physical incapacity among athletes, with a negative impact on training and competition [1]. Clinical pilates uses minimal loads to improve trunk activation and endurance, aiming to improve posture and movement control through the strengthening of the core, leading to the decrease of low back pain [2,3]. The goal of this study was to verify the benefits on low back pain, through the application of a clinical pilates program, during six weeks, in young handball players of the youth team, junior and senior, of the Ginásio Clube do Sul. Materials and methods: This study included 18 male, athletes with lumbar pain from training overload existing for more than 3 months. The subjects were, randomized into two groups: experimental group (EG) and control group (CG). The EG performed a clinical Pilates program before the usual handball weekly workouts and the control group performed only the usual handball weekly workouts, and they were given a flyer with trunk strengthening and postural control exercises. The study lasted six weeks, with evaluation moments at week 0 (M0) and in the end of week 6 (M1). The study was approved by Ginásio Clube do Sul and all participants gave their informed consent. Results: Both groups were homogeneous regarding participants age (19.66 ± 2.85 vs 19.61 ± 2.96) and weight (80.78 ± 7.35 vs 80.58 ± 5.43). In the mean values, athletes in the EG had lower values than the CG in functional disability (2.1 ± 1.5 vs 3.25 ± 1.75) and pain score (3 ± 1.5, vs 4.25 ± 0.7), and higher values for endurance of the trunk (flexors - 73.9 ± 24.5, extensors - 75.3 ± 24.7, right lateral flexors - 41.1 ± 26.5, left lateral flexors - 43.35 ± 26.8; ± 24.1, vs flexors 56.1 ± 24.1, extensors- 63.2 ± 15.6, right lateral flexors- 32.8 ± 16.1, left lateral flexors- 35.5 ± 19.2). Within groups, we could see statistically significant differences in the functional disability variable (p = 0.02), pain intensity (p = 0.03) and endurance in the trunk flexors (p = 0.04) and extensors (p = 0.01) for the EG, from M0 to M1; In CG, there are no statistically significant differences except from pain intensity (p = 0.04). The functional disability and pain intensity value decreased from M0 to M1 in the EG with a moderate to high effect. The value of endurance of trunk flexors and extensors increase from M0 to M1 with a moderate to high effect. Discussion and conclusion: Clinical Pilates has benefits on handball athletes with low back pain, leading to a decrease in pain intensity and functional incapacity, as well as an increase in the endurance of the trunk flexors and extensors. Despite clinical Pilates have promising effects controling pain symptomatology, functional capacity and endurance of the trunk in young Handball athletes, further investigation with larger sample is needed.
Effect of Curcuma domestica Stock Solution on Layer Performance, Egg Quality, and Antioxidant Activity

The aim of this research was to evaluate the effect of Curcuma domestica stock solution on layer performances, egg quality, and antioxidant activity of egg yolk. A total number of 32 Lohman LSL-lite white laying hens were divided into 4 treatments; there were 8 replication birds in individual cages. Laying hens were fed with 4 experimental diets, basal diet and diets with 1%, 2%, and 3% of Curcuma domestica 10% stock solution. Eggs were collected daily and analyzed of the eggs which were divided into three age stages, namely stage 1 (week 22 - 25), stage 2 (26 - 29), and stage 3 (30 - 33), respectively. The respective layer performances and egg quality were determined every week at every age stage. Antioxidant activity and color stability were determined every week at second age stage. The data was analysed using GLM in a windows-based software package, SAS version 9.1. Data was obtained from a different level, age stage, and interaction among level and age stage. The differences were tested by LSM. Significant level used in the group comparisons was set at p<5%. The addition of Curcuma domestica 10% stock solution did significantly improve laying performances, egg quality, and antioxidant activity. Addition of 3% Curcuma domestica stock solution increased layer performances including water consumption, hen day egg production, and egg weight as well as antioxidant activity including FRAP, iron chelating, and DPPH on egg yolk. Moreover, the addition of 2% Curcuma domestica 10% stock solution increased egg shell thickness and egg shell strength. In summary, the use of 3% addition of Curcuma domestica 10% stock solution had ability to improve layer performances and antioxidant activity of egg yolk on laying hens.
BEst (Biomarker Estimation): Health Biomarker Estimation Non-invasively and Ubiquitously

BEst (Biomarker Estimation): Health Biomarker Estimation Non-invasively and Ubiquitously Md Kamrul Hasan, B.S., M.S. Marquette University, 2019 This dissertation focuses on the non-invasive assessment of blood-hemoglobin levels. The primary goal of this research is to investigate a reliable, affordable, and user-friendly point-of-care solution for hemoglobin-level determination using fingertip videos captured by a smartphone. I evaluated videos obtained from five patient groups, three from the United States and two from Bangladesh, under two sets of lighting conditions. In the last group, based on human tissue optical transmission modeling data, I used near-infrared light-emitting diode sources of three wavelengths. I developed novel image processing techniques for fingertip video analysis to estimate hemoglobin levels. I studied video images creating image histogram and subdividing each image into multiple blocks. I determined the region of interest in a video and created photoplethysmogram signals. I created features from image histograms and PPG signals. I used the Partial Least Squares Regression and Support Vector Machine Regression tools to analyze input features and to build hemoglobin prediction models. Using data from the last and largest group of patients studied, I was able to develop a model with a strong linear correlation between estimated and clinically-measured hemoglobin levels. With further data and methodological refinements, the approach I have developed may be able to define a clinically accurate public health applicable tool for hemoglobin level and other blood constituent assessment.
Camellia sinensis leaf extracts lacking catechins exert depigmentary effects through ERK-dependent, MiTF-mediated tyrosinase downregulationin melan-a cells and a human skin equivalent

Green tea from Camellia sinensis, a popular beverage worldwide, is also considered a herbal medicine. The bioactive compounds of green tea include polyphenols, polysaccharides, amino acids, and vitamins. Tea polyphenols are composed of various catechins such as epigallocatechin-3-gallate (EGCG), whereas polysaccharides include complex pectic substances and glycoproteins. Unfractionated C. sinensis leaf extracts show various pharmacological effects that are attributable to catechins, which include antimelanogenic properties. Most studies have focused on the biological function of catechins in green tea, and the effects of C. sinensis leaf extracts lacking catechins (CSLE-LC) have received little research attention. We examined the skin-whitening properties of the fraction lacking catechins. The melanin content in melan-a cells was significantly reduced, as has been shown for unfractionated C. sinensis extracts and catechins. We also elucidated the molecular mechanism underlying the antimelanogenic effects of CSLE-LC on skin melanocytes. Our results show that CSLE-LC acts through inhibition of MiTF and subsequent activation of extracellular-signal regulated kinase (ERK) to reduce tyrosinase protein levels. We confirmed the whitening ability of CSLE-LC using a human skin equivalent. Our findings provide the first evidence that CSLE-LC could exert efficient antimelanogenesis activity, and suggest that polysaccharides as well as catechins contribute to the whitening efficacy of C. sinensis leaf extracts.
A Primal-dual Learning Algorithm for Personalized Dynamic Pricing with an Inventory Constraint

We consider the problem of a firm seeking to use personalized pricing to sell an exogenously given stock of a product over a finite selling horizon to different consumer types. We assume that the type of an arriving consumer can be observed, but the demand function associated with each type is initially unknown. The firm sets personalized prices dynamically for each type and attempts to maximize the revenue over the season. We provide a learning algorithm that is near optimal when the demand and capacity scale in proportion. The algorithm utilizes the primal–dual formulation of the problem and learns the dual optimal solution explicitly. It allows the algorithm to overcome the curse of dimensionality (the rate of regret is independent of the number of types) and sheds light on novel algorithmic designs for learning problems with resource constraints.
Color Constancy by Reweighting Image Feature Maps

In this study, a novel illuminant color estimation framework is proposed for computational color constancy, which incorporates the high representational capacity of deep-learning-based models and the great interpretability of assumption-based models. The well-designed building block, feature map reweight unit (ReWU), helps to achieve comparative accuracy on benchmark datasets with respect to prior state-of-the-art deep learning based models while requiring more compact model size and cheaper computational cost. In addition to local color estimation, a confidence estimation branch is also included such that the model is able to simultaneously produce point estimate and its uncertainty estimate, which provides useful clues for local estimates aggregation and multiple illumination estimation. The source code and the dataset have been made available (https://github.com/QiuJueqin/Reweight-CC).
Learning Latent Superstructures in Variational Autoencoders for Deep Multidimensional Clustering

We investigate a variant of variational autoencoders where there is a superstructure of discrete latent variables on top of the latent features. In general, our superstructure is a tree structure of multiple super latent variables and it is automatically learned from data. When there is only one latent variable in the superstructure, our model reduces to one that assumes the latent features to be generated from a Gaussian mixture model. We call our model the latent tree variational autoencoder (LTVAE). Whereas previous deep learning methods for clustering produce only one partition of data, LTVAE produces multiple partitions of data, each being given by one super latent variable. This is desirable because high dimensional data usually have many different natural facets and can be meaningfully partitioned in multiple ways.
Blockchain and Cryptocurrency: A comparative framework of the main Architectural Drivers

Blockchain is a decentralized transaction and data management solution, the technological weapon-of-choice behind the success of Bitcoin and other cryptocurrencies. As the number and variety of existing blockchain implementations continues to increase, adopters should focus on selecting the best one to support their decentralized applications (dApps), rather than developing new ones from scratch. In this paper we present a framework to aid software architects, developers, tool selectors and decision makers to adopt the right blockchain technology for their problem at hand. The framework exposes the correlation between technological decisions and architectural features, capturing the knowledge from existing industrial products, technical forums/blogs, experts' feedback and academic literature; plus our own experience using and developing blockchain-based applications. We validate our framework by applying it to dissect the most outstanding blockchain platforms, i.e., the ones behind the top 10 cryptocurrencies apart from Bitcoin. Then, we show how we applied it to a real-world case study in the insurtech domain.