Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Thermodynamic Constraint to the Solution Space of Metabolic Pathway Design Using sAnalyzer Tool

One of most important stages of metabolic engineering is organism design. One of methods that allows process design is modeling or in silico approach. Application of biological models instead of biological experiments is cheaper and does not require specific resources. sAnalyzer tool uses reactions data to construct new metabolic pathways and predict its feasibility to transform one metabolite to another one using particular chassis organism represented by a model. sAnalyzer searches possible reactions connections in full solution space of all accessible reactions. One of reaction parameters used to predict its flow direction is reaction thermodynamic data - Gibbs free energy (ΔrG) value, which shows how much energy is needed for reaction to flow in specific direction. sAnalyzer tool demonstrates how thermodynamic thresholds of ΔrG value impacts possible solution space of metabolites transformation pathways on the example of using glycerol as substrate for bacteria Z.mobilis model. The solutions are ranked by flux over the pathway of interest, biomass production ability and integrated parameters derived from involved metabolites and reactions.
Agentic ethnography: inclusive interviews of young adults with significant disabilities on the transition from school

ABSTRACT This paper is a methodological reflection drawn from a study on the transition from school into young adulthood in Aotearoa New Zealand. During this process, the personal priorities of young adults with significant disabilities often becomes overpowered by those involved in their post-school planning. Through the experiences of young adults living this experience, empirical considerations are offered on the topic of agency. Agentic ethnography combines inclusive ideologies and research methods with theoretical underpinning of the capability approach. The product is adapted interview formats used to develop agentic participation in research to foster inclusive knowledge on the topic of transition. Practical implications for research and the educational field are provided to illustrate collaborative processes and products that not only collect ‘voice’ but importantly, have it be heard.
Voltammetric Behavior of ethambutol on a glassy carbon electrode and its application

The anodic voltammetric behavior of ethambutol in the presence of various electrolytes was studied by direct-current voltammetry, differential-pluse voltammetry and cyclic voltammetry at a glassy carbon electrode. In a medium of 0.039 mol/L Na2HPO4, an oxidative peak of ethambutol was obtained. The peak potential is at about 1.04 V( vs. Ag/AgCl). The height of the peak is linearly increased with the concentration of ethambutol over the range of 3 mg/Lsimilar to1000 mg/L. The method has been used for the direct determination of ethambutol in tablets. The average recovery of ethambutol in urine samples is 84.7%. Experimental results proved that the electrode reaction was diffusion controlled and irreversible.
Hydrochemistry of the Dammam Unconfined Aquifer Southern Desert, West Iraq

The type of groundwater in the studied area is slightly brackish. In general, the dominant water type is calcium-sulfate. The reasons behind these different chemical groundwater types can be referred to the active ion exchange between the groundwater of the Dammam aquifer and Rus Formation. The groundwater of the Dammam unconfined aquifer is not suitable for human drinking in all the parameters properties. The groundwater class is fair in the Qasir Al-Ukhaider area, while the Shebcha area and Al-Salman area are poor class except the eastern part of Al-Salman area is very poor.
A Laser‐Processed Silicon Solar Cell with Photovoltaic Efficiency in the Infrared

Hyperdoped and textured silicon created with a femtosecond laser in the presence of SF6 gas has a highly absorbing surface with extended spectral sensitivity in the infrared. The main drawback of this micro‐ and nanostructured material for photovoltaic (PV) cells is an increase in charge‐carrier recombination at the surface due to the typically poor crystallinity of the surface layer. Laser annealing postprocessing of the black silicon (b‐Si) surface is used to greatly reduce the crystal structure defects while maintaining sub‐bandgap absorption. The back side of the cell is functionalized with spin‐on doping and laser fired contacts to make an interdigitated back‐contact proof‐of‐concept b‐Si solar cell. It is shown that this cell has measurable PV efficiency in the sub‐bandgap infrared, a promising step toward developing intermediate‐band silicon PVs.
Degradation of Hazardous Organics via Cathodic Flow-through Process Using a Spinel FeCo2O4/CNT Decorated Stainless-Steel Mesh

Cathodic membranes were applied with Fe reagent to enhance the mass transport of electro-Fenton (EF) by means of forced permeation. However, the considerable amount of toxic Fe reagent left in electrolytes may cause secondary pollution. Also, the membranes without active EF catalysts exposed low removal efficiency due to insufficient surface catalytic activity. In this work, an advanced flow-through process without toxic Fe reagent was developed using modified stainless steel (SS) mesh with high catalytic activity. The surface of SS mesh was decorated by catalytically-active FexCo3-xO4 nanoparticles and functionalized carbon nanotubes (CNTs). The synergistic effect between Fe and Co elements enhanced the electro-Fenton efficiency, and the optimal n(Fe): n(Co) ratio was determined at 1:2 from the degradation rate of pollutants and H2O2. The addition of FeCo2O4/CNT enhanced the first-order reaction rate k to 2.60 times on bisphenol A (BPA) removal, and 2.16 times on sulfamethoxazole (SMX) removal, compared to an undecorated mesh. Consequently, 94% of BPA were eliminated after 60 min and 100% of SMX were eliminated after 120 min, respectively, under a low current density of 2.84 mA cm. The total concentration of leached Fe/Co ions into the electrolyte was only around 2.4 μmol L after the treatment.
Learning for Control: An Inverse Optimization Approach

We present a learning method to learn the mapping from an input space to an action space, which is particularly suitable when the action is an optimal decision with respect to a certain unknown cost function. We use an inverse optimization approach to retrieve the cost function by introducing a new loss function and a new hypothesis class of mappings. A tractable convex reformulation of the learning problem is also presented. The method is effective for learning input-action mapping in continuous input-action space with input-output constraints, typically present in control systems. The learning approach can be effectively transformed to learn a Model Predictive Control (MPC) behaviour and a case study to mimic an MPC is presented, which is a rather computationally heavy control strategy. Simulation and experimental results show the effectiveness of the proposed approach.
Knowledge audit as an important tool in organizational management: A review of literature

The purpose of this paper is to review current literature on knowledge management and highlight the importance of knowledge audit in bringing about a holistic knowledge solution to knowledge management. Based on the review of literature on knowledge management, this study points out the role of knowledge audit in solving the challenges in organizations’ tacit and explicit knowledge. Specifically, the paper concentrates on knowledge audit, knowledge risk and international and national standards on knowledge audit processes. The contribution of this study to literature are the suggestions that knowledge risk and international standards procedures could be applied to knowledge audit. The important conclusion of this paper is that knowledge risk management has not been fully explored in the study of knowledge audit. The paper addresses the research question of what organizations must embark on in the process of knowledge audit. The paper attempts to provide answer to the question by highlighting the importance of knowledge audit and the reasons why organizations carry out knowledge audit, and also the existing knowledge audit frameworks and methodologies.
Deep Learning for Binaural Sound Source Localization with Low Signal-to-noise Ratio

A novel deep learning (DL) method is proposed for binaural sound source localization with low SNR. Firstly, the binaural sound signals are decomposed into several channels by using Gammatone filter. Secondly, the 4 feature parameters of Head-related Transfer Function, interaural time difference (ITD), interaural coherence (IC), interaural level difference (ILD), and interaural phase difference (IPD) are extracted. Thirdly, ITD and IC go through a Deep Belief Network (DBN) to determine the quadrant of the sound source and reduce the positioning range. Then, ITD, IC, ILD, and IPD go through a Deep Neural Network (DNN) to obtain the azimuthal angle within 90 degrees. Experimental results show that the proposed algorithm can solve the front-back confusion, and obtain a superior performance with lower complexity and higher precision under low SNR conditions.
A Pragmatic Controlled Trial of Forest Bathing Compared with Compassionate Mind Training in the UK: Impacts on Self-Reported Wellbeing and Heart Rate Variability

Forest Bathing, where individuals use mindfulness to engage with nature, has been reported to increase heart rate variability and benefit wellbeing. To date, most Forest Bathing studies have been conducted in Asia. Accordingly, this paper reports the first pragmatic controlled trial of Forest Bathing in the United Kingdom, comparing Forest Bathing with a control comprising an established wellbeing intervention also known to increase heart rate variability called Compassionate Mind Training. Sixty-one university staff and students (50 females, 11 males) were allocated to (i) Forest Bathing, (ii) Compassionate Mind Training or (iii) Forest Bathing combined with Compassionate Mind Training. Wellbeing and heart rate variability were measured at baseline, post-intervention and three-months follow-up. There were improvements in positive emotions, mood disturbance, rumination, nature connection and compassion and 57% of participants showed an increase in heart rate variability. There were no significant differences between conditions, showing that Forest Bathing had equivalence with an established wellbeing intervention. The findings will help healthcare providers and policy makers to understand the effects of Forest Bathing and implement it as a feasible social prescription to improve wellbeing. Future research needs to involve clinical populations and to assess the effects of Forest Bathing in a fully powered randomised controlled trial.
Práticas de cuidado hospitalares no final de vida: revisão integrativa

Decisoes sobre cuidados as pessoas em final de vida envolvem diversos aspectos, representando desafio e mobilizando medicos e enfermeiros, profissionais que se sobressaem na tomada de decisoes. Esta revisao integrativa de literatura objetivou identificar praticas de cuidado de medicos e enfermeiros em final de vida no hospital. A coleta de dados ocorreu entre janeiro e fevereiro de 2020 nas bases de dados Web of Science, Scopus e na Medical Literature and Retrivial System Online (MEDLINE). 58 artigos foram selecionados com os seguintes temas: sedacao paliativa, ordem de nao reanimacao cardiopulmonar, comunicacao e tomada de decisao, eutanasia e suicidio assistido, retirada ou limitacao de tratamentos mantenedores da vida, tratamentos oncologicos e cuidados terminais. Conclui-se que as praticas de cuidado em final de vida centralizam-se em sintomas fisicos e possuem o intuito de aliviar sofrimento. Suspender ou limitar reanimacao cardiopulmonar, hidratacao, nutricao e hemodialise, bem como realizacao de eutanasia ou suicidio assistido apresentam maior controversia.
Differential expression of pinoresinol-lariciresinol reductase gene in relation to podophyllotoxin accumulation in different plant organs of endangered anticancer species Podophyllum peltatum

Pinoresinol-lariciresinol reductase (PLR) is a key enzyme in podophyllotoxin (PTOX) biosynthesis pathway, which catalyzes the conversion of pinoresinol into secoisolariciresinol, a central precursor for the PTOX biosynthesis. Podophyllum peltatum is an important anticancer species, and PTOX content is obviously different from various plant organs. Therefore, investigation of PLR gene expression facilitates the understanding of the molecular mechanisms of the variation of the PTOX content in different organs from P. peltatum as well as its biosynthesis mechanisms, suggesting that it is an important gene for metabolic engineering of the PTOX. The PTOX was found in all the test organs (root, rhizome, petiole, fruit, leaf and flower), with significant differences among them (p<0.05). The highest PTOX content (2.8018 ± 0.23%) was found in rhizome, which was 30 times higher than the lowest PTOX content in fruit. Furthermore, tissue expression profile showed that P. peltatum PLR (PpPLR) was expressed in all the test organs except for the flower. The highest and lowest expression level was found in rhizome and leaf, respectively. The expression profile of PpPLR was inconsistent with the PTOX content variation in the test organs except for the rhizome, suggesting that the PTOX biosynthetic organ is not necessarily its storage organ. After the initial synthesis, PTOX can be transferred to its storage organ, such as the rhizome.
Towards Rebuilding the Design Model of Programs by Static Analysis and Abstraction

It is difficult to understand a complex software program if its detailed design is not available. A model-rebuilding approach is presented to recover the design on an abstract level. In this approach, by static analysis of the program, a design is constructed and described in an abstract program which includes all behaviour that is observable at a set of selected program points. The approach provides an effective way for the understanding of complex programs.
Cold‐Season Arctic Amplification Driven by Arctic Ocean‐Mediated Seasonal Energy Transfer

The Arctic warming response to greenhouse gas forcing is substantially greater than the rest of the globe. It has been suggested that this phenomenon, commonly referred to as Arctic amplification, and its peak in boreal fall and winter result primarily from the lapse‐rate feedback, which is associated with the vertical structure of tropospheric warming, rather than from the sea‐ice albedo feedback, which operates mainly in summer. However, future climate model projections show consistently that an overall reduction of sea‐ice in the Arctic region leads to a gradual weakening of Arctic amplification, thereby implying a key role for sea‐ice albedo feedback. To resolve this apparent contradiction, we conduct a comprehensive analysis using atmosphere/ocean reanalysis data sets and a variety of climate model simulations. We show that the Arctic Ocean acts as a heat capacitor, storing anomalous heat resulting from the sea‐ice loss during summer, which then gets released back into the atmosphere during fall and winter. Strong air‐sea heat fluxes in fall/winter in sea‐ice retreat regions in conjunction with a stably stratified lower troposphere lead to a surface‐intensified warming/moistening, augmenting longwave feedback processes to further enhance the warming. The cold‐season surface‐intensified warming/moistening is found to virtually disappear if ocean‐atmosphere‐sea ice interactions are suppressed, demonstrating the importance of ice insulation effect and ocean heat uptake/release. These results strongly suggest that the warm‐season ocean heat recharge and cold‐season heat discharge link and integrate the warm and cold season feedbacks, and thereby effectively explain the predominance of the Arctic amplification in fall and winter.
Cryptic mortality of North Atlantic right whales

Evaluations of the conservation status of the endangered North Atlantic right whale as well as many other wildlife species often rely extensively on counts and cause‐of‐death determinations of carcasses found accidentally or during dedicated surveys. Even when survey effort dedicated to a population is extensive, many deaths may go unseen. We used an abundance estimation model to derive estimates of cryptic mortality for North Atlantic right whales and found that observed carcasses accounted for only 36% of all estimated death during 1990–2017. We found strong evidence that total mortality varied over time, and that observed carcass counts were poor predictors of estimated annual numbers of whales dying. Importantly, there were substantial differences between fractions of deaths determined to be entanglement related during necropsy (49%) and the fraction of cryptic deaths suffering serious injuries related to entanglement (87%). Although we concluded that a single year's observations produced poor estimates of carcass detection rates due to the volatility of ratios of small counts, ratio estimates of data pooled over periods of consistent survey may offer better information on detection rates. Additionally, it appears unwise to consider cause of death determinations from detected carcasses as representative of cause‐specific mortality rates in right whales given the large number of seriously injured whales from entanglement that are likely part of the unseen mortality.
Creation of Auditory Augmented Reality Using a Position-Dynamic Binaural Synthesis System—Technical Components, Psychoacoustic Needs, and Perceptual Evaluation

For a spatial audio reproduction in the context of augmented reality, a position-dynamic binaural synthesis system can be used to synthesize the ear signals for a moving listener. The goal is the fusion of the auditory perception of the virtual audio objects with the real listening environment. Such a system has several components, each of which help to enable a plausible auditory simulation. For each possible position of the listener in the room, a set of binaural room impulse responses (BRIRs) congruent with the expected auditory environment is required to avoid room divergence effects. Adequate and efficient approaches are methods to synthesize new BRIRs using very few measurements of the listening room. The required spatial resolution of the BRIR positions can be estimated by spatial auditory perception thresholds. Retrieving and processing the tracking data of the listener’s head-pose and position as well as convolving BRIRs with an audio signal needs to be done in real-time. This contribution presents work done by the authors including several technical components of such a system in detail. It shows how the single components are affected by psychoacoustics. Furthermore, the paper also discusses the perceptive effect by means of listening tests demonstrating the appropriateness of the approaches.
Mapping and Analysis Burned Area Based on LANDSAT 8 OLI/TIRS and Hotspots Data in Palangkaraya of Central Kalimantan Province - Indonesia

Indonesia experienced with big forest fire every year especially within dry season. Palangkaraya City of Central Kalimantan province is the most prone area with fire. It was reported that Palangkaraya had the highest risk of fire in 2019 which caused smog that disrupts people breathing and their daily activities. Indonesian government is paying a great attention to manage and suppress the fire. People are encouraged to provide information of burning location, responsible company and burned area in the incident. This study determined burned area in Palangkaraya using Normalized Burned Ratio (NBR) method and the results were validated with hotspots data acquired from LAPAN website. The results showed that 64.24% burned area is classified as low severity and only 1.04% of burned area is classified as high severity. The remaining area with 31.84% categorized in moderate low severity and 2.88% categorized in moderate high severity. The validation result showed that 100%of burned area is confirmed valid with the occurring hotspots.
Türkiye’de aromaterapinin etkisine yönelik yapılan hemşirelik tezlerinin incelenmesi

Amac: Bu arastirma Turkiye’de aromaterapinin etkisini degerlendirmek uzere yapilmis hemsirelik lisansustu tez calismalarinin incelenmesi amaciyla yapilmistir. Gerec ve Yontemler: Bu calisma dokuman analizi yontemi kullanilarak yapilmistir. Turkiye Ulusal Tez Veri Tabani’nda “aromaterapi”, “nonfarmakolojik yontemler” ve “hemsirelik” kelimeleri kullanilarak tarama yapilmistir. Tarama sonucu 66 teze ulasilmistir. Tezlerden ikisi tam erisime acik olmadigi, 13’u hemsirelik tezi olmadigi ve yedi tez aromaterapinin etkisini incelemedigi icin degerlendirme disi birakilmis, calisma 44 tez uzerinden yurutulmustur. Bulgular: Tezlerin 24’u yuksek lisans ve 20’si doktora tezidir. Tezlerin tamaminda aromaterapi olarak esansiyel yag kullanilmistir. Aromatik yaglar inhaler olarak ya da ve masaj yontemiyle uygulanmistir. Tezlerin 25’inde aromaterapinin kaygi/anksiyete/stres uzerindeki, 23 tezde uyku ve 19 tezde ise agri uzerindeki etkisi incelenmistir. Calismalarin tamamina yakininda kullanilan aromaterapinin incelenen degisken uzerinde etkili oldugu bulunmustur. Sonuc: Son on yilda hemsireler tarafindan aromaterapinin etkisine yonelik yapilan lisansustu tez calismalarinin sayisi artmistir. Calismalarin sonuclari aromaterapinin agri, kaygi, anksiyete, stres ve uyku gibi degiskenler uzerinde olumlu etkileri oldugunu gostermektedir.
Quartz-Crystal Microbalance Monitoring for the Adsorption of Cell Adhesive Proteins onto a Titanium Surface

The quartz crystal microbalance (QCM) method can detect the amounts of proteins adsorbed on biomaterials by a frequency shift of an oscillating quartz crystal. In the present study, we observed the adsorption behavior of proteins onto a titanium surface by using 27-MHz QCM. As proteins, two cell adhesive proteins, fibronectin and collagen, and albumin were evaluated. The QCM apparatus used was a 27-MHz AFFINIX Qnn(Initium Co., Ltd., Tokyo, Japan)with 500-nL cells. The temperature was maintained at 25±1°C and the solution in the cells was stirred during the measurements. A titanium sensor was prepared by titanium sputtercoating onto an Au electrode. Bovine albumin, human plasma fibronectin and atelocollagen were dissolved in phosphate-buffered saline(PBS)solution(pH 7.4)at a concentration of 50 ng/mL. Each protein solution was injected into the PBS solution in the cells of the QCM apparatus. The decrease of frequency was monitored and the amounts of proteins adsorbed onto the titanium surface at 30 min after the injection were calculated by Sauerbrey’s equation. The apparent reaction rate, Kobs, was also obtained. A slight frequency decrease was observed upon injection of albumin, and the frequency decrease for fibronectin adsorption was larger than that for albumin adsorption. Collagen significantly showed the largest decrease of frequency shift. Significant differences in the adsorbed amounts were seen among the three proteins. Namely, collagen exhibited the significantly largest adsorption amount on titanium, and albumin showed the significantly smallest amount. Kobs for collagen was significantly the smallest, and that of albumin was significantly the