Miracle-dz/UniFAR-FTUs huggingface dataset:
Artificial intelligence for the public sector: opportunities and challenges of cross-sector collaboration

Public sector organizations are increasingly interested in using data science and artificial intelligence capabilities to deliver policy and generate efficiencies in high-uncertainty environments. The long-term success of data science and artificial intelligence (AI) in the public sector relies on effectively embedding it into delivery solutions for policy implementation. However, governments cannot do this integration of AI into public service delivery on their own. The UK Government Industrial Strategy is clear that delivering on the AI grand challenge requires collaboration between universities and the public and private sectors. This cross-sectoral collaborative approach is the norm in applied AI centres of excellence around the world. Despite their popularity, cross-sector collaborations entail serious management challenges that hinder their success. In this article we discuss the opportunities for and challenges of AI for the public sector. Finally, we propose a series of strategies to successfully manage these cross-sectoral collaborations. This article is part of a discussion meeting issue ‘The growing ubiquity of algorithms in society: implications, impacts and innovations’.
Chorus: truly distributed distributed-MIMO

Distributed MIMO has long been known theoretically to bring large throughput gains to wireless networks. Recent years have seen significant interest and progress in developing practical distributed MIMO systems. However, these systems only distribute the transmission function across the multiple nodes. The control fabric that synchronizes the nodes to a common reference phase still fundamentally requires a single leader that all nodes in the network are capable of hearing. This paper presents Chorus, a truly distributed distributed-MIMO system. Chorus is leaderless - all nodes are peers, and jointly transmit the synchronization signal used by other nodes to synchronize to a common reference phase. The participation of all nodes in the network in the synchronization signal enables Chorus to scale to large networks, while being resilient to node failures or changes in network connectivity, and without imposing onerous management burdens on network administrators. We implement and evaluate Chorus and demonstrate that it can synchronize effectively without the need for a single leader, scale to large networks where no leader node can be heard by all others, and provide 2.7X throughput improvement over traditional leader-based systems.
Mutation and Epistasis in Influenza Virus Evolution

Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus’s capacity to generate diversity through mutation and reassortment. Because many new traits require multiple mutations and mutations are frequently combined by reassortment, epistatic interactions between mutations play an important role in influenza virus evolution. While mutation and epistasis are fundamental to the adaptability of influenza viruses, they also constrain the evolutionary process in important ways. Here, we review recent work on mutational effects and epistasis in influenza viruses.
Characterizing the HIV Care Continuum and Identifying Barriers and Facilitators to HIV Diagnosis and Viral Suppression Among Black Transgender Women in the United States

Background: Although black transgender women (BTW) experience high prevalence of HIV in the United States, no characterization of the HIV care continuum exists for this population. This study addresses this gap by (1) characterizing the HIV care continuum, and (2) exploring correlates of HIV diagnosis and viral suppression among a community-based sample of BTW. Methods: Data came from Promoting Our Worth, Equality, and Resilience (POWER). From 2014 to 2017, POWER recruited BTW who attended Black Pride events in 6 U.S. cities. Participants completed a behavioral health survey and were offered onsite HIV testing. Simple frequencies were used to characterize the HIV care continuum, and multivariable logistic regression analysis was used to identify correlates of HIV diagnosis and viral suppression. Results: A total of 422 BTW provided completed data for our analysis, 45.0% of whom were living with HIV. Over half of the HIV-positive BTW (51.4%) reported being undiagnosed at the time of survey, and 24.5% reported viral suppression. Incarceration and a lack of access to medical care were significantly and positively associated with an undiagnosed HIV-positive status in multivariable models. Incarceration, homelessness, polydrug use, physical assault, intimate partner violence, and current hormone use were significantly and negatively associated with viral suppression in multivariable models. Conclusions: Developing and implementing interventions that address timely HIV diagnosis may assist in informing the HIV disparity among BTW in the United States. Interventions should address the fundamental causes of poor health in this population.
Value of monitoring circulating donor‐reactive memory B cells to characterize antibody‐mediated rejection after kidney transplantation

Antibody‐mediated rejection (ABMR) is defined by specific histopathological lesions and evidence of circulating donor‐specific antibodies (DSA). Although DSA are not always detectable, monitoring donor‐reactive memory B cells (mBC) could identify patients at risk of developing ABMR. Peripheral donor‐reactive mBC using a novel HLA B cell ELISpot assay, serum DSA, and numbers of different B cell subsets were assessed in 175 consecutive kidney transplants undergoing either for‐cause or 6‐ and 24‐month surveillance biopsies for their association with main histological lesions of ABMR and impact on allograft outcome. In 85 incident for‐cause biopsies, high frequencies of donor‐reactive mBC were detected in all 16 (100%) acute ABMR/DSA+ and most chronic ABMR, with or without DSA (24/30[80%] and 21/29[72.4%], respectively). In a longitudinal cohort of 90 nonsensitized patients, a progressively higher expansion of donor‐reactive mBC than de novo DSA was observed at 6 and 24 months (8.8% vs 7.7% and 15.5% vs 11.1%, respectively) and accurately identified patients with ongoing subclinical ABMR (area under the curve = 0.917 and area under the curve = 0.809, respectively). An unsupervised hierarchical cluster analysis revealed a strong association between donor‐reactive mBC with main fundamental allograft lesions associated with ABMR and conferred a significant deleterious impact on graft outcome. Monitoring donor‐reactive mBC may be useful to further characterize humoral rejection after kidney transplantation.
Evaluation of buriti endocarp as lignocellulosic substrate for second generation ethanol production

The production of lignocellulosic ethanol is one of the most promising alternatives to fossil fuels; however, this technology still faces many challenges related to the viability of the lignocellulosic alcohol in the market. In this paper the endocarp of buriti fruit was assessed for ethanol production. The fruit endocarp was characterized physically and chemically. Acid and alkaline pre-treatments were optimized by surface response methodology for removal of hemicellulose and lignin from the biomass. Hemicellulose content was reduced by 88% after acid pretreatment. Alkaline pre-treatment reduced the lignin content in the recovered biomass from 11.8% to 4.2% and increased the concentration of the cellulosic fraction to 88.5%. The pre-treated biomass was saccharified by the action of cellulolytic enzymes and, under optimized conditions, was able to produce 110 g of glucose per L of hydrolyzate. Alcoholic fermentation of the enzymatic hydrolyzate performed by Saccharomyces cerevisiae resulted in a fermented medium with 4.3% ethanol and a yield of product per substrate (YP/S) of 0.33.
Persistence of Immunity When Using Different Human Papillomavirus Vaccination Schedules and Booster-Dose Effects 5 Years After Primary Vaccination

Abstract Background There are limited data regarding the duration of immunity induced by different human papillomavirus (HPV) vaccination schedules and the immunogenicity of a booster dose of both bivalent HPV vaccine (bHPV) or quadrivalent HPV vaccine (qHPV). Methods Follow-up of a nonrandomized clinical trial to evaluate the 5-year antibody persistence of the bHPV in girls (age, 9–10 years) and women (age, 18–24 years). Noninferiority of the 2-dose versus 3-dose schedule among girls was evaluated at months 54 (n = 639) and 64 (n = 990). Girls vaccinated with a 2-dose schedule of bHPV or qHPV received a booster dose of either vaccine at month 61. Immunogenicity was measured using a virus-like particle–based enzyme-linked immunosorbent assay. Geometric mean titers (GMTs) for HPV16/18 were estimated after stratification by vaccination schedule and age group. Results At months 54 and 64, the 2-dose schedule remained noninferior to the 3-dose schedule. GMTs remained above natural infection levels across all age groups up to 64 months. After the booster, anti-HPV16/18 GMTs increased exponentially with the same pattern, regardless of vaccine administered. No safety concerns were identified with the booster dose. Conclusions A 2-dose schedule is highly immunogenic in girls, suggesting a high immune memory. Thus, a booster dose is likely to be unprofitable, considering the low global immunization coverage. Clinical Trials Registration NCT01717118
Composite Cationic Exchange Membranes Prepared from Polyvinyl Alcohol (PVA) and Boronic Acid Copolymers for Alkaline Diffusion Dialysis

Boronic acid copolymers with a large number of functional groups were obtained via a free radical polymerization method. The corresponding composite membranes for alkaline diffusion dialysis (DD) were prepared by a crosslinking reaction between polyvinyl alcohol (PVA) and the as-obtained boronic acid copolymers. The composite membranes possessed water uptake (WR) of 122.1–194.4%, ion exchange capacities (IECs) of 0.79–1.17 mmol/g, as well as both good mechanical stability (tensile strength of 40.7–49.9 MPa and elongation at break of 52.1–121.1%) and thermal stability. The as-prepared membranes were stable in 2 M NaOH solution at 65 °C with a swelling degree and mass loss of as-prepared membranes in the range of 305–368% and 9.2–22%, respectively. A NaOH/Na2WO4 mixture was used to investigate the separation properties of as-prepared membranes via the DD process. Results indicated that the dialysis coefficients of OH− (UOH) were in the range of 0.0079–0.0150 m/h, while the separation factors (S) were in the range of 26.6–53.2. The functional groups from boronic acid copolymer and –OH from PVA were demonstrated to promote the ion transport synergistically.
A New Efficient Wavelet-Based Adaptive Algorithm for Automatic Speech Quality Enhancement

In this paper, we address the problem of speech enhancement by adaptive filtering algorithm. A particular attention has been made for the backward blind source separation (BBSS) algorithm and its use in speech enhancement application. In this paper, we propose to implement the BBSS algorithm in the Wavelet-domain. The proposed backward wavelet BBSS (WBBSS) algorithm is then used in speech enhancement test. The new WBBSS shows better performances in terms of convergence speed and steady state in comparison with BBSS one. The obtained results have been evaluated in terms of segmental SNR and cepstral distance criteria and confirm the best performance of the proposed WBBSS algorithm.
User Space Network Drivers

The rise of user space packet processing frameworks like DPDK and netmap makes low-level code more accessible to developers and researchers. Previously, driver code was hidden in the kernel and rarely modified-or even looked at-by developers working at higher layers. These barriers are gone nowadays, yet developers still treat user space drivers as black-boxes magically accelerating applications. We want to change this: every researcher building high-speed network applications should understand the intricacies of the underlying drivers, especially if they impact performance. We present ixy, a user space network driver designed for simplicity and educational purposes to show that fast packet IO is not black magic but careful engineering. ixy focuses on the bare essentials of user space packet processing: a packet forwarder including the whole NIC driver uses less than 1,000 lines of C code. This paper is partially written in tutorial style on the case study of our implementations of drivers for both the Intel 82599 family and for virtual VirtIO NICs. The former allows us to reason about driver and framework performance on a stripped-down implementation to assess individual optimizations in isolation. VirtIO support ensures that everyone can run it in a virtual machine. Our code is available as free and open source under the BSD license at https://github.com/emmericp/ixy.
Appendicular skeletal morphology in minute salamanders, genus Thorius (amphibia: Plethodontidae): Growth regulation, adult size determination, and natural variation

Patterns of growth and variation of the appendicular skeleton were examined in Thorius, a speciose genus of minute terrestrial plethodontid salamanders from southern Mexico. Observations were based primarily on ontogenetic series of each of five species that collectively span the range of adult body size in the genus; samples of adults of each of seven additional species provided supplemental estimates of the full range of variation of limb skeletal morphology.
Mild Place Illusion: A Virtual Reality Factor to Spark Creativity in Writing

Developments in Virtual Reality (VR) technology have modified the creative potential of each individual. We introduce a new concept, called "mild place illusion", as a new paradigm for designing VR-based user interfaces targeted at stimulating creativity. We show that for creative tasks - such as creative writing, new product ideation, and brainstorming - a "just-enough" amount of place illusion leads to a greater self-perception of creativity, as opposed to a "full-level" place illusion. This is a somewhat unexpected result since one would suppose, a priori, to have the full-level place illusion as the optimal setup for stimulating creativity. We considered that the methodology in this work was fairly complex, but our results show -- through a data triangulation approach -- that we were able to identify more consistent and personal creative experiences. Therefore, the main contribution of this paper is a new paradigm for designing VR user interfaces targeted at stimulating creativity by showing that a "one-illusion interspace" leads to a greater self-perception of creativity.
Cucurbitacin E Inhibits Proliferation and Migration of Intestinal Epithelial Cells via Activating Cofilin

The proliferation and migration of intestinal epithelial cell is important to the barrier integrity of intestinal epithelium. Cucurbitacin E (CuE) is one of the tetracyclic triterpenoids extracted from the cucurbitaceae that has been shown to inhibit cancer cell growth, tumor angiogenesis and inflammatory response. Nevertheless, the role of Cucurbitacin E in regulating the proliferation and migration of intestinal epithelial cells remain unclear. In this study, the human intestinal epithelial cell line Caco-2 was treated with CuE and the effects of CuE on cell cycle, proliferation, migration and actin dynamics in Caco-2 cells were investigated successively. We found that CuE significantly inhibited the cell proliferation and migration, inducing the cell cycle arrest in G2/M phase and disrupting the actin dynamic balance in Caco-2 cells. Finally, we showed that CuE inhibited cofilin phosphorylation by suppressing the phosphorylation of both LIM kinase (LIMK)1 and LIMK2 in vitro, resulting in the activation of cofilin, which is closely associated with cell proliferation and migration. Therefore, our studies provided the first evidence that CuE inhibited the proliferation and migration of intestinal epithelial cells via activating cofilin, and CuE is a potential candidate in intestinal disease therapy.
Probabilistic Learning of Torque Controllers from Kinematic and Force Constraints

When learning skills from demonstrations, one is often required to think in advance about the appropriate task representation (usually in either operational or configuration space). We here propose a probabilistic approach for simultaneously learning and synthesizing torque control commands which take into account task space, joint space and force constraints. We treat the problem by considering different torque controllers acting on the robot, whose relevance is learned probabilistically from demonstrations. This information is used to combine the controllers by exploiting the properties of Gaussian distributions, generating new torque commands that satisfy the important features of the task. We validate the approach in two experimental scenarios using 7- DoF torque-controlled manipulators, with tasks that require the consideration of different controllers to be properly executed.
Trust Modelling in 5G mobile networks

5G technologies will change the business landscape for mobile network operation. The use of virtualization through SDN, NFV and Cloud computing offer significant savings of CAPEX and OPEX, but they also allow new stakeholders to rent infrastructure capacity and operate mobile networks, including specialized networks supporting so-called vertical applications serving specific business sectors. In the resulting diverse stakeholder communities, the old trust assumptions between network operators will no longer apply. There is a pressing need for a far broader understanding of trust in such networks if they are to operate safely and securely for the engaged stakeholder communities. This paper describes the work carried out in the 5G-ENSURE project to address this need.
Accumulation by Dispossession and Public–Private Biomedical Pluralism in Romanian Health Care

ABSTRACT Neoliberal reforms in health care are an accumulation by dispossession. In examining this in Romania, we show that neoliberal reforms led to an uneven landscape of public and private care. We document how patients variously situated in Romanian society respond to this situation, and demonstrate the instability of their strategies—restraining from formal care, lifting-off from public care and hooking-up to private care. Public–private biomedical pluralism proves to be detrimental to vulnerable and better-off patients alike.
In-body backscatter communication and localization

Backscatter requires zero transmission power, making it a compelling technology for in-body communication and localization. It can significantly reduce the battery requirements (and hence the size) of micro-implants and smart capsules, and enable them to be located on-the-move inside the body. The problem however is that the electrical properties of human tissues are very different from air and vacuum. This creates new challenges for both communication and localization. For example, signals no longer travel along straight lines, which destroys the geometric principles underlying many localization algorithms. Furthermore, the human skin backscatters the signal creating strong interference to the weak in-body backscatter transmission. These challenges make deep-tissue backscatter intrinsically different from backscatter in air or vacuum. This paper introduces ReMix, a new backscatter design that is particularly customized for deep tissue devices. It overcomes interference from the body surface, and localizes the in-body backscatter devices even though the signal travels along crooked paths. We have implemented our design and evaluated it in animal tissues and human phantoms. Our results demonstrate that ReMix delivers efficient communication at an average SNR of 15.2 dB at 1 MHz bandwidth, and has an average localization accuracy of 1.4cm in animal tissues.
A Dual Backward Adaptive Algorithm for Speech Enhancement and Acoustic Noise Reduction

This paper deals with the problem of noise reduction for hands-free communications when two microphones are in use. Recently, forward-and-backward blind source separation (BSS) structures have been suggested to solve acoustic noise reduction and speech enhancement problems. Therefore, we propose a new algorithm that is based on the combination between the dual backward (BSS) structure and the Simplified Fast Transversal Filter (SFTF) algorithm. The obtained results which are expressed in terms of several objective criteria prove and confirm the superiority and the good performances of the proposed dual backward blind SFTF (DBSFTF) in comparison with the classical dual backward normalized least mean square (DBNLMS) algorithm.
Nutrient supply alters transcriptome regulation in adipose tissue of pre-weaning Holstein calves

Performance of dairy cows can be influenced by early life nutrient supply. Adipose tissue is diet sensitive and an important component in that process as it is involved in the regulation of energetic, reproductive and immunological functions. However, it is not clear how early life nutrition alters the molecular regulation of adipose tissue in calves and potentially adult individuals. This study aimed at determining how differences in pre-weaning nutrient supply alter gene expression profiles and physiology in omental adipose tissue. A total of 12 female Holstein calves were fed two levels of milk replacer supply: a restricted amount of 11.72 MJ of metabolizable energy (ME) intake per day (n = 6) or an enhanced amount of 1.26 MJ ME intake per kg of metabolic body weight (BW0.75), resulting in supply from 17.58 to 35.17 MJ ME intake per day (n = 6). All calves had ad libitum access to a commercial calf starter and water. Analysis of the transcriptome profiles at 54 ± 2 days of age revealed that a total of 396 out of 19,968 genes were differentially expressed (DE) between groups (p < 0.001, FDR < 0.1). The directional expression of DE genes through Ingenuity Pathway Analysis showed that an enhanced nutrient supply alters adipose tissue physiology of pre-weaned calves. Several biological functions were increased (Z-score > +2), including Lipid Metabolism (Fatty Acid Metabolism), Cell Cycle (Entry into Interphase, Interphase, Mitosis and Cell Cycle Progression), Cellular Assembly and Organization (Cytoskeleton Formation and Cytoplasm Development) and Molecular Transport (Transport of Carboxylic Acid). These changes were potentially orchestrated by the activation/inhibition of 17 upstream regulators genes. Our findings indicate that adipose tissue of calves under an enhanced nutrient supply is physiologically distinct from restricted calves due to an increased development/expansion rate and also a higher metabolic activity through increased fatty acid metabolism.