Miracle-dz/UniFAR-FTUs huggingface dataset:
Die volkswirtschaftliche Bedeutung der Energiewirtschaft

Die ausreichende und bestandige Verfugbarkeit von Energie ist fur hoch entwickelte Industrielander eine unabdingbare Voraussetzung fur ihre wirtschaftliche Entwicklung. Das gilt fur alle Bereiche einer modernen Volkswirtschaft, vom Produktionssektor uber den Transport- und den Dienstleistungssektor bis hin zu den privaten Haushalten. Durch die Verwendung von Energie in ihren verschiedenen Formen ist es zusammen mit dem Einsatz anderer Produktionsfaktoren moglich, eine anhaltende Steigerung der Arbeitsproduktivitat zu erreichen, die Arbeitsteilung weiter zu entwickeln und zu optimieren sowie den Aufwand fur zeitraubende Tatigkeiten deutlich zu reduzieren. Vor dem Hintergrund des fur entwickelte Volkswirtschaften in nahezu allen Lebensbereichen notwendigen Bedarfs an Energie und ihres daraus resultierenden Stellenwerts hat das ifo Institut die volkswirtschaftliche Bedeutung der gesamten Energiewirtschaft und insbesondere der Stromversorgung untersucht. Themenschwerpunkte und wesentliche Ergebnisse der Studie werden in diesem Beitrag vorgestellt.
Evaluation of coronary artery remodeling in patients with acute coronary syndrome and stable angina by multislice computed tomography.

BACKGROUND Multislice computed tomography (MSCT) was used to evaluate coronary artery remodeling in patients with acute coronary syndrome (ACS) and stable angina (SA). METHODS AND RESULTS MSCT was performed in 31 patients with ACS and 26 patients with SA and intravascular ultrasound (IVUS) was performed in 28 of these 57 patients. In both the MSCT and IVUS analyses, coronary artery remodeling was assessed by the remodeling index (RI): RI >1.10 was defined as positive coronary artery remodeling (PCAR) and RI <0.95 was defined as negative coronary artery remodeling (NCAR). The RI assessed by MSCT closely correlated with that of IVUS (r=0.86, n=28). The vessel area at the region of maximum luminal narrowing was also comparable between the MSCT and IVUS measurements (r=0.92). PCAR was present in 19 patients (61.3%) with ACS, but in none of the patients with SA (p<0.0001). However, NCAR was present in only 1 patient with ACS (3.2%), but was present in 18 patients (62.9%) with SA. The RI was significantly larger in patients with ACS (1.19+/-0.18) than in those with SA (0.89+/-0.10, p<0.0001). CONCLUSION MSCT accurately assesses coronary artery remodeling.
Preclinical Safety and Pharmacokinetic Profile of Ferumoxtran-10, an Ultrasmall Superparamagnetic Iron Oxide Magnetic Resonance Contrast Agent

Objectives:This report presents an overview of preclinical data available on ferumoxtran-10, an ultrasmall superparamagnetic iron oxide nanoparticular contrast agent proposed for lymph node magnetic resonance imaging. Materials and Methods:Pharmacokinetic, safety pharmacology, single- and repeat-dose toxicity, reproduction toxicity, and genotoxicity studies were performed with ferumoxtran-10 given intravenously (bolus injection) in mice, rats, rabbits, dogs, and monkeys. Results:Ferumoxtran-10 was taken up by macrophages, mostly in liver, spleen, and lymph nodes, within 24 hours after bolus injection and underwent progressive metabolism. Toxicity was observed only at very high exposure levels and mainly was linked to a massive iron load after repeated injections. Ferumoxtran-10 was not mutagenic but was teratogenic in rats and rabbits. Discussion:The preclinical pharmacokinetic and safety profile of ferumoxtran-10 appears to be satisfactory in view of its proposed use as a single-dose diagnostic agent in human for MR imaging of lymph nodes.
Consideraciones estratégicas ante la implantación de un sistema de identificación por radiofrecuencia (RFID)

Los sistemas RFID despiertan una gran expectacion entre los profesionales y academicos de la gestion logistica. Sin embargo, existen determinados factores que retardan la adopcion generalizada de esta tecnologia, como su alto coste en comparacion a otras tecnologias de identifi cacion automatica o la falta de estandares. En esta comunicacion se identifi can estos factores y se presenta el analisis coste –benefi cio que una organizacion realizaria ante la decision de implantar o no un sistema de identifi cacion por radiofreciencia.
Characteristics analysis and performance evaluation for interleaved boost converter with integrated winding coupled inductor

The integrated magnetic component for interleaved converters has been developed in order to satisfy the demand for high power density of converters. The close-coupled inductor method and the loosely coupled inductor method are well known as techniques that can achieve downsizing of magnetic components. As another approach, the integrated winding coupled inductor has already been proposed. However, the advantages of interleaved converter with the integrated winding coupled inductor have yet to be elucidated fully as compared with the other methods. Therefore, characteristics of inductor ripple current and magnetic flux in the core for the integrated winding coupled inductor are analyzed and evaluated in this paper. As a result of the analysis, integrated winding coupled inductor method provides three attractive features as compared with loosely coupled inductor. The effectiveness of the integrated winding coupled inductor is discussed from theoretical and experimental point of view.
Murine pulmonary myocardium: Developmental analysis of cardiac gene expression

Long‐standing observations that cardiac muscle exists in the walls of the pulmonary and caval veins have recently been confirmed at the molecular level (Lyons et al. [1990] J. Cell Biol. 111:2427–2436; Springall et al. [1988] Thorax 43:44–52; Subramaniam et al. [1991] J. Biol. Chem. 266:24613–24620). Using ventricle‐ and atrial‐specific riboprobes, we determined that the pulmonary myocardium exhibits an atrial pattern of cardiac‐specific gene expression. Additionally, the developmental pattern of expression was studied using a riboprobe specific to the α‐cardiac myosin heavy chain (α‐MHC) gene transcript. We find that α‐MHC gene expression is first detectable in the lung between 13.9–14.3 days post‐coitum. Extension of the α‐MHC specific hybridization signal into the pulmonary venous bed progresses through the neonatal period. The data are consistent with the hypothesis that the extension of α‐MHC gene expression into the lung occurs via the migration of atrial myoblasts into the vein during atrial septation and remodeling of the sinus venosus and pulmonary venous trunk. © 1994 Wiley‐Liss, Inc.
A Case Study of the Use of the Viable System Model in the Organization of Software Development

This chapter considers the usefulness of the Viable System Model (VSM) in the study of organizational adaptation. The VSM is a rigorous organizational model that was developed from the study of cybernetics and has been given considerable attention by management science research. The chapter presents a longitudinal case study that focuses upon a software development team. The VSM was useful in diagnosing the likely consequences of different organizational designs and in prescribing an alternative solution.
Personalized News Event Retrieval for Small Talk in Social Dialog Systems

This thesis explores the area of personalized news event retrieval in the context of social dialog systems. We developed the NewsTeller system which retrieves a relevant news event based on a user query and the user’s general interests (both represented as list of keywords). The retrieved news event can then be used by a social dialog system to initiate news-related small talk. The NewsTeller system is implemented as a pipeline with four stages: In a rst step, a (large) set of potentially relevant news events is retrieved. As about 84% of the found events do not ful ll our syntactic and semantic well-formedness criteria, the second step in the pipeline is concerned with ltering the found events. This ltering is done by a classi er which was trained on a data set of about 6,000 events. The results obtained in a ten-fold cross-validation indicate that a global random forest classi er is superior to an ensemble of specialized classi ers that were trained on speci c subproblems. The global classi er reaches a precision of 63.04% and a recall of 59.55%. The third step in the pipeline is concerned with ranking the remaining events according to their expected relevance and selecting the event with the highest expected relevance. Four ordered classes are used to describe an event’s relevance: Irrelevant, Partially Relevant, Relevant, and Very Relevant. Following the “learning to rank” approach from information retrieval, this task is framed as a regression problem on the relevance values of the events which is solved by training a random forest regressor on a data set of about 3,200 events. Two di erent approaches were compared: using only features de ned on the events and the user query and using also features de ned on the user’s general interests. The results in a user-level leave-one-out evaluation indicate that both regressors have comparable performance in avoiding Irrelevant events and that taking into account the user’s interests helps to improve the detection of Relevant and Very Relevant events. In the fourth step of the pipeline, a summary of the selected news event is created. This is done by extracting the sentence in which the event was mentioned. For evaluating the system, a user study with 48 participants was conducted. The results of this evaluation show that the two regression-based approaches are signi cantly better than a random baseline with respect to avoiding Irrelevant events. We could however not con rm our hypothesis that using information about the users’ general interests helps to improve the detection of Relevant and Very Relevant events.
A dual-wideband split-ring PIFA for wireless applications

A compact dual-band planar inverted-F antenna (PIFA) working in the GPS (1572 MHz), DCS (1800 MHz) and WiMAX (3500 MHz) frequency bands is presented. The antenna based on split-ring (SR) resonators provides 30% and 11% impedance bandwidth performance at the respective bands. Also, the antenna exhibits uniform radiation pattern at both frequency bands.
Being a Counselor on Today's Campus: Roles, Contributions, and Special Challenges

Until quite recently, those seeking a better general understanding of the practice of counseling on a college or university campus were relegated to reading general counseling textbooks, which contained an occasional reference or chapter on counseling as applied on a college campus. Sharkin’s Being a College Counselor on Today’s Campus (2012) provided the higher education community, as well as the counseling and student affairs professions, with a new resource; and it spoke directly to the practice of contemporary psychological counseling on campus.
Nonopioid additives to local anaesthetics for caudal blockade in children: a systematic review

Background: Caudal epidural injection with local anaesthetics is a popular regional technique used in infants and children. A disadvantage of caudal blockade is the relatively short duration of postoperative analgesia. Opioids have traditionally been added to increase the duration of analgesia but have been associated with unacceptable side‐effects. A number of nonopioid additives have been suggested to increase the duration of analgesia.
The node of Ranvier in the central nervous system.

The axolemma of myelinated nerve fibres of the central nervous system has been examined both at nodes and in the paranodal region. In the paranodal region, the outside of the axolemma is separated from the outer surface of the plasma membrane bounding the inner aspect of the paranodal cytoplasm by a distance of only 25–30 A, so that the two membranes form a complex. In longitudinal sections, a periodicity may be observed within this complex. It has been shown that this is mainly due to the form of the outer dense layer of the axolemma, which is modified into a series of bands or rings that circumscribe the axon. Each band is 120–150 A wide and the centre to centre spacing is 250–300 A. At the node, the axolemma does not show a periodicity and is not covered by a myelin sheath, but in the axoplasm beneath it there is a layer of osmiophilic granular material, about 250 A thick.
Behavior and performance of message-oriented middleware systems

The middleware technology used as the foundation of Internet-enabled enterprise systems is becoming increasingly complex. In addition, the various technologies offer a number of standard architectures that can be used by designers as templates to build applications. However, there is little concrete understanding in the software industry on the strengths and weaknesses of competing technologies, and the different trade-offs that various component architectures impose. The SACT Group at CSIRO has qualitatively and quantitatively evaluated a number of commercially available Message-Oriented Middleware (MOM) systems. This paper focuses on the results obtained from the performance evaluation of the IBM's MQSeries V5.2. It presents an overview of the technology, and discusses the metric used in this study for performance measurement The test results related to the sustainable performance of the system using various test configurations are described and their implications discussed.
Three-dimensional microscale numerical simulation of smoldering

A three-dimensional numerical tool for the simulation of smoldering in fixed beds of solid fuels is presented in this paper. The description is based on the microscale equations, in a detailed discretized image of the porous medium. Simplifying assumptions are used, but the local coupling of the transport and reaction mechanisms is fully preserved. A set of 2D and 3D simulations demonstrates the ability of the model to handle a variety of situations, and to provide detailed local information. In particular, it is shown that severe thermal disequilibrium exists in some regimes, which preclude a straightforward application of simple macroscopic models.
Elevated Preoperative Fasting Serum Glucose Levels Increase the Risk of Postoperative Mediastinitis in Patients Undergoing Open Heart Surgery

Abstract We conducted a case-control study to investigate the relationship between preoperative fasting serum glucose and postoperative mediastinitis in patients undergoing open heart surgery. Multivariate analysis revealed that a glucose level of 126 mg/dL or greater was associated with a significantly increased risk of mediastinitis (OR, 5.25; P = .002).
Effect of heliotherapy on the cost of psoriasis

A 2‐year trial was conducted to evaluate the cost‐effectiveness of heliotherapy for psoriasis. The course and cost of psoriasis of 46 Finnish patients were first closely monitored for 1 year, then the patients received a 4‐week supervised heliotherapy treatment in the Canary Islands, Spain, after which they continued to be followed for another year. Heliotherapy dramatically reduced the severity of psoriasis and also seemed to have favourable long‐term effects on psoriasis. The mean direct cost of the 4‐week heliotherapy for one patient was FIM12,289 (£1 = FIM7.0 in 1989). The cost of flights and half‐board in Spain formed nearly 60% (FIM7033) of the total cost. In the year preceding heliotherapy, the mean direct annual cost of antipsoriasis therapy was FIM7335 and in the year after FIM5700, a reduction of 22% in annual costs; this change was not statistically significant because there were large variations in costs among patients. The costs of heliotherapy exceeded manyfold the mean monthly cost of conventional psoriasis therapy. There were no overall savings using heliotherapy in those patients suffering mainly from moderately severe psoriasis. Heliotherapy saved costs only in those patients with severe psoriasis that required expensive medication or ward treatment. Although heliotherapy cannot be regarded as an economical treatment for the average patients with psoriasis, it clears psoriasis effectively and is preferred by patients. Thus, heliotherapy constitutes an alternative for patients suffering severe psoriasis.
Degradation of maternal mRNA in mouse embryos: Selective degradation of specific mRNAs after fertilization

During oogenesis, mRNA is actively transcribed and accumulated in growing oocytes, but this transcription stops before the oocytes grow to their full size. The accumulated maternal mRNA is used for protein synthesis in the oocytes during meiotic maturation and even in the embryos to sustain development after fertilization. Therefore, the degradation of accumulated maternal mRNA starts during meiotic maturation, but its rate is slow. Nevertheless, some mRNA species should rapidly degrade after fertilization if they encode proteins that play a role in specific events during meiosis and are detrimental for development after fertilization. In this study, to identify the selective degradation of maternal transcripts after fertilization, we sought mRNAs that are degraded in the early hours after fertilization by constructing an oocyte cDNA library after subtracting the cDNA of embryos at the mid one‐cell stage. H1oo, c‐mos, tPA (tissue type plasminogen activator gene), and Gdf9 were identified as genes whose transcripts undergo rapid degradation after fertilization. RT‐PCR analysis showed that none of these transcripts was expressed during pre‐implantation development once they were eliminated, suggesting that the mRNA species that are required for oogenesis, but not for early pre‐implantation development, are degraded rapidly after fertilization. Microinjection of chimeric mRNAs in which the coding and 3′‐untranslated regions (3′UTR) were exchanged between c‐mos and hypoxanthine phosphoribosyltransferase mRNAs revealed that the 3′UTR plays a role in the rapid degradation that occurs after fertilization. Cytoplasmic polyadenylation elements (CPEs) was found near a poly(A) signal in the 3′UTR of all the mRNA species identified as rapidly degrading mRNA. The mechanism for the selective degradation is discussed, in relation to its biological significance. Mol. Reprod. Dev. © 2005 Wiley‐Liss, Inc.
Meningiomas of the transverse – sigmoid sinus junction area

Meningiomas with exclusive or prevalent dural attachment over the transverse-sigmoid sinus junction area represent a well-defined subgroup of posterior fossa meningiomas. This study reports 13 cases of this localisation (10.8% of all infratentorial meningiomas). In this series, six patients (46%) were discovered as an incidental MR finding. One patient with a small (1.5 cm) meningioma presented with an intracranial hypertension syndrome due to severe obstruction of the unique transverse-sigmoid sinus junction. A MR angiography was performed in 11 patients; it showed intraluminal tumour in two cases with dominant and unique transverse sinus, respectively. Tumour removal with excision of the outer dural layer and coagulation of the dural attachment (Simpson II) was performed in 11 cases; in two others with focal sinus invasion, removal of the small intravenous tumour fragment was not performed (Simpson III). No post-operative complications occurred. Remission of pre-operative symptoms was obtained in all symptomatic cases. The management of the transverse-sigmoid sinus junction is the main problem of meningiomas of this region. Excision of the outer dural layer and coagulation of the dural attachment are in our opinion sufficient in most cases, even when there is tumour invasion of the patent venous lumen. The resection of the sinus wall should be reserved to cases with a totally obstructed segment and symmetrical or asymmetrical but present transverse and sigmoid sinuses.
Prognostic factors for return to work after a first compensated episode of back pain.

OBJECTIVES--To determine which factors measured at baseline and during the course of treatment influence time to return to work after a first compensated episode of back pain. METHODS--The design is a treatment inception cohort including 305 compensated workers out of 402 eligible ones presenting at two rehabilitation centres for conventional treatment. Crude and adjusted rate ratios (RRs) along with 95% confidence intervals (95% CIs) were estimated with the Cox's proportional hazards regression. RESULTS--50% of workers had not returned to work after 112 days of follow up, and 11.3% still had not after 270 days. At the end of the study period (maximum follow up time was 1228 days), 230 workers (75.4%) had returned to work, 6.5% had not, and a similar percentage had retired, gone into vocational training, or returned to school. In the final model stratified for radiating pain during treatment, which was an important prognostic variable, workers between 21 to 30 years of age had a greater chance of returning to work (RR (95% CI) 1.43 (1.04 to 1.98) than those > or = 30. The other factors associated with a greater chance of returning to work were: a diagnosis of sprain or pain upsilon a diagnosis of intervertebral disc disorder (2.20 (1.23-3.91)), < 30 days of waiting between the accident and the beginning of treatment (1.30 (0.96 to 1.77)), a good flexion at baseline (1.52 (1.04 to 2.23)), absence of neurological symptoms during treatment (1.40 (0.98-2.00)), > 24 months of employment in the industry (1.49 (1.10 to 2.03)), working for a public industry upsilon a private one (1.63 (1.21 to 2.19)), and the ability to take unscheduled breaks (1.45 (1.06 to 1.97)). CONCLUSIONS--Even with a first episode of back pain, time to return to work is long and the proportion not returning is high. Return to work as expected is influenced by disease and host characteristics but also by social and work factors. Reinstatement programmes should account for all these factors.
Isolation and Total Synthesis of Kirkamide, an Aminocyclitol from an Obligate Leaf Nodule Symbiont.

The new C7N aminocyclitol kirkamide (1) was isolated from leaf nodules of the plant Psychotria kirkii by using a genome-driven (1)H NMR-guided fractionation approach. The structure and absolute configuration were elucidated by HRMS, NMR, and single-crystal X-ray crystallography. An enantioselective total synthesis was developed, which delivered kirkamide (1) on a gram scale in 11 steps and features a Ferrier carbocyclization and a Pd-mediated hydroxymethylation. We propose that kirkamide is synthesized by Candidatus Burkholderia kirkii, the obligate leaf symbiont of Psychotria kirkii. Kirkamide (1) was shown to be toxic to aquatic arthropods and insects, thus suggesting that bacterial secondary metabolites play a protective role in the Psychotria/Burkholderia leaf nodule symbiosis.
Survival in high-risk prostate cancer patients is predicted by mir-221, which regulates proliferation, apoptosis and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3

Burkhard Kneitz, Markus Krebs, Charis Kalogirou, Maria Schubert, Steven Joniau, Hein van Poppel, Evelyne Lerut, Susanne Kneitz, Claus Jürgen Scholz, Philipp Ströbel, Manfred Gessler Hubertus Riedmiller, 1,2 Martin Spahn 1 Department of Urology and Paediatric Urology, University Hospital Wuerzburg, Würzburg, Germany 2 Department of Urology, University Hospital Bern, Inselspital, Bern, Switzerland Department of Urology, University Hospital Leuven, Leuven, Belgium Department of Pathology, University Hospital Leuven, Leuven, Belgium Physiological Chemistry I, Biocenter, University of Wuerzburg, Wuerzburg, Germany IZKF Laboratory for Microarray Applications, University Hospital of Wuerzburg, Wuerzburg, Germany Department of Pathology, University Hospital Goettingen, Goettingen, Germany Developmental Biochemistry, Biocenter, University of Wuerzburg, Wuerzburg, Germany.