Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct Puncture Endoscopic Assisted Gastrostomy: An Alternative Technique, Case Report

Enteral feeding benefits are worldly renown, severely ill patients and oncological patients have better outcomes, survival rates and improvement in-quality life standards [1-6]. Gastrostomy is the procedure ideal for management of these chronic and ill patients [7]. Within many available techniques PEG tube is an effective access to provide enteral feeding for patients with impaired oral intake, and now a day’s oncologic patients have become a demand group for enteral nutrition [2,5,7-10], especially the ones coursing with head, neck and esophagealneoplasia. 33-69% of patients that need chemo-radiotherapy for upper aero digestive tract require PEG tube placement [11-13]. This group disserves particular attention since tumoral seeding in gastrostomy stomas have been reported [13-17], primary from the oropharynx, hypopharynx, oral cavity and larynx. Being the pull technique the most associated with metastases reports, reason why new methods for gastrostomy placement have been studied, especially for the ones that require pre-surgical feeding or for nutritional feeding after mayor head and neck surgical intervention [12,18,19]. With this purpose, general surgery and gastroenterology departments of the Fundación Santa Fé University Hospital of Bogotá Colombia presents an alternative technique: Direct puncture endoscopic assisted Gastrostomy reducing the risk of tumoral cell implant at the path and stoma.
Nonsteroidal Anti-Inflammatory Drugs and Their Neuroprotective Role After an Acute Spinal Cord Injury: A Systematic Review of Animal Models

Study Design: Systematic review. Objective: Spinal cord injuries (SCIs) resulting in motor deficits can be devastating injuries resulting in millions of health care dollars spent per incident. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a potential class of drugs that could improve motor function after an SCI. This systematic review utilizes PRISMA guidelines to evaluate the effectiveness of NSAIDs for SCI. Methods: PubMed/MEDLINE, CINAHL, PsycINFO, Embase, and Scopus were reviewed linking the keywords of “ibuprofen,” “meloxicam,” “naproxen,” “ketorolac,” “indomethacin,” “celecoxib,” “ATB-346,” “NSAID,” and “nonsteroidal anti-inflammatory drug” with “spinal. ” Results were reviewed for relevance and included if they met inclusion criteria. The SYRCLE checklist was used to assess sources of bias. Results: A total of 2960 studies were identified in the PubMed/MEDLINE database using the above-mentioned search criteria. A total of 461 abstracts were reviewed in Scopus, 340 in CINAHL, 179 in PsycINFO, and 7632 in Embase. A total of 15 articles met the inclusion criteria. Conclusions: NSAIDs’ effectiveness after SCI is largely determined by its ability to inhibit Rho-A. NSAIDs are a promising therapeutic option in acute SCI patients because they appear to decrease cord edema and inflammation, increase axonal sprouting, and improve motor function with minimal side effects. Studies are limited by heterogeneity, small sample size, and the use of animal models, which might not replicate the therapeutic effects in humans. There are no published human studies evaluating the safety and efficacy of these drugs after a traumatic cord injury. There is a need for well-designed prospective studies evaluating ibuprofen or indomethacin after adult spinal cord injuries.
Cross-generational collaboration in the workplace: a study of millennial generation collaboration preferences in a government agency.

The collaboration style of the Millennial generation is shaped by their interactions and experiences, which influences the way they prefer to collaborate in professional interactions. This interpretive phenomenological analysis (IPA) study identified, through a focus on individual interviews, the collaboration preferences of the Millennial generation in their professional relationships. To better understand the experiences that shape the Millennial generation’s interactions with coworkers, this research study focuses specifically on answering the research question: How do Millennials prefer to collaborate in the workplace? Two key tenets of Karl Mannheim’s (1927) Theory of Generations is the theoretical framework for this research study. Mannheim’s theory focuses on how external factors and experiences can shape the collective consciousness of a generation. The first and third tenets of Mannheim’s theory are pillars of this study and provide a strong structure to develop how to conduct a research study with Millennials to gain an understanding of how their experiences shape their collaboration preferences. The first tenet outlines the specific characteristics of generations in society and argues that generations are not concrete groups formed solely through demographic characteristics, such as age, gender, or class. The third tenet suggests that fresh contacts, or individual and personally meaningful interactions with individuals, shape generational consciousness. The core of this study is on understanding how external factors shape the experiences of generations and subsequently impact their collaboration. The data gathered identified themes of this research study that resulted in three major findings related to how the Millennial generation prefers to collaborate in the workplace. The first finding is that the Millennial generation has an innate ability to adjust to the workplace to address conflict and create successful collaborative results with their colleagues. The second
Atomic Scale Understanding of the Epitaxy of Perovskite Oxides on Flexible Mica Substrate

The excellent functionalities of perovskite oxides and the growing demands for flexible devices lead to great interests on epitaxial growth of functional oxide films on flexible mica substrates. Understanding the film epitaxy on the substrate with a very different crystal structure is a key issue for the optimization of the film growth and hence properties. Such understanding largely depends on knowing the atomic structure of the interfaces between the films and the substrates. Here, the interface between the epitaxial films of SrTiO3 on the fluorophlogopite mica substrate is studied in detail. Two types of interfaces, clean or with secondary phase, exist in this system, leading to two types of crystallographic orientation relationships. Atomic‐resolution scanning transmission electron microscopy images reveal that at the clean interface the (111) Sr–O3 atomic plane of SrTiO3 interacts with the (001) (SiAl)2–O3 plane of mica. This interface structure and thus the epitaxy of the film are understood in light of the strong similarity of the oxygen sublattices in these two atomic planes. First‐principles calculations demonstrate strong bonding of the atoms at the interface, which is also corroborated by the observation of misfit dislocations at the interfaces.
IoTility: Architectural Requirements for Enabling Health IoT Ecosystems

The increasing ubiquity of the Internet of Things (IoT) has the potential to drastically alter the way healthcare systems are utilized at home or in a care environment. Smart things offer new ways to assist in general patient wellness, such as promoting an active and healthy lifestyle and simplifying treatment management. We believe smart health things bring new requirements not typically addressed in traditional IoT systems, and that an architecture targeting these devices must address such requirements to fully utilize their potential and safe usage. We believe such an architecture will help improve adoption and efficacy, closing gaps between the variety of emerging health IoT systems. In this paper, we present a number of requirements we consider integral to the continued expansion of the digital health IoT ecosystem (Health IoT). We consider the current landscape of IoT in relation to these requirements and present solutions that address two pressing requirements: 1) democratizing mobile health apps (giving users control and ownership over their app and data), and 2) making mobile apps act and behave like any other thing in an IoT. We present an implementation and evaluation of these Health IoT requirements to show how health-specific solutions can drive and influence the design of more generalized IoT architectures.
Metastatic bone diseases

Prikaz nacina tumorskog prijenosa u skelet, scintigrafski prikaz metastaza raka dojke, pluca, prostate, melanoma, tumora bubrega, ženskih spolnih organa, probsvnih organa, tumora glave i vrata i neuroblastoma
Analysis of the effect of territorial factors on regional innovation in the state of São Paulo, Brazil

This paper examines the geography of innovation in the Sao Paulo micro-regions. Using data on innovation inputs and outputs at the regional level, this paper examines how territorial factors affect innovation in the regions of the state of Sao Paulo, Brazil. Previous studies show that local innovation is linked to the quantity and quality of innovative inputs, and the main characteristics of regions are configured as regional driving forces of innovation. However, most studies on this subject have focused on developed countries; few studies have examined developing countries. In this way, this paper presents new empirical evidence on the role of territorial factors in fostering innovation in Brazilian regions. The main results show that local R&D expenditures and the local externalities generated by diversified industry and social filters are the main drivers of regional innovation.
Analyzing Dissatisfaction Factors of Weather Service Users Using Twitter and News Headlines

Social media is a massive dataset in which individuals' thoughts are freely recorded. So there have been a variety of efforts to analyze it and to understand the social phenomenon. In this study, Twitter was used to define the moments when negative perceptions of the Korean Meteorological Administration (KMA) were displayed and the reasons people were dissatisfied with the KMA. Machine learning methods were used for sentiment analysis to automatically train the implied awareness on Twitter which mentioned the KMA July-October 2011-2014. The trained models were used to validate sentiments on Twitter 2015-2016, and the frequency of negative sentiments was compared with the satisfaction of forecast users. It was found that the frequency of the negative sentiments increased before satisfaction decreased sharply. And the tweet keywords and the news headlines were qualitatively compared to analyze the cause of negative sentiments. As a result, it was revealed that the individual caused the increase in the monthly negative sentiments increase in 2016. This study represents the value of sentiment analysis that can complement user satisfaction surveys. Also, combining Twitter and news headlines provided the idea of analyzing the causes of dissatisfaction that are difficult to identify with only satisfaction surveys. The results contribute to improving user satisfaction with weather services by efficiently managing changes in satisfaction.
Merging into strings of cooperative-adaptive cruise-control vehicles

Abstract Cooperative-adaptive cruise-control (CACC) offers the potential to increase roadway capacity by decreasing the size of gaps between vehicles. However, smaller gaps may reduce drivers’ ability to safely enter CACC strings. Two driving simulator experiments explored merging in CACC strings (also known as CACC platoons). In Experiment 1, drivers attempted to merge into a continuous stream of simulated CACC vehicles using either a CACC vehicle with merge assist, a CACC vehicle without merge assist, or a manually driven vehicle. All merges made using merge assist were successful. In contrast, one-third of CACC drivers without merge assist and half of manual drivers were involved in a collision during their first merge attempt. The crash rate appeared to be largely due to participants’ expectation that CACC vehicles would create a larger gap to accommodate their merging vehicle. Experiment 2 explored the validity of this expectation. Participants encountered two merge events while traveling in a CACC string: a successful merge that occurred immediately in front of their vehicle and an unsuccessful merge attempt that resulted in a crash in their travel lane. Responses to merging vehicles were influenced by the gap size their vehicle maintained, but not by their preferred following distance. The vast majority of participants traveling in a CACC string did not create larger gaps during the typical merge, and instead only took over longitudinal control when in immediate danger of a collision. The finding suggests that features, such as merge assist, could help ensure the safety of vehicles entering CACC strings.
Characterization of Metal‐zeolite Composite Catalysts: Determining the Environment of the Active Phase

Metal‐zeolite composite catalysts are attracting increased attention due to their unique multifunctional properties. However, it is challenging to identify the physicochemical environment of the active phase, which is essential to improve our understanding of the structure‐performance relationships of such complex catalysts. In this work, commonly available analytical techniques (FTIR, TEM, XRD, etc.) and state‐of‐the‐art user instrumentation (XAS, SANS, e‐TEM, etc.) are reviewed with respect to their applications at different stages of the catalyst lifetime, from early nucleation, to the reaction mechanism and deactivation. Each technique is discussed in detail with examples to provide suggestions and guidelines for choosing the characterization technique(s) that are most appropriate for determining the desired structure‐property relationships of metal‐zeolite composite catalysts. Understanding the most appropriate applications of characterization techniques promotes development of novel synthesis methodologies, and in turn, applications for designing active, selective and stable multifunctional metal‐zeolite composite catalysts.
Caregivers’ experiences in accessing health care services for their school-going children in low resource communities of KwaZulu-Natal, South Africa.

46 Background . 48 Methods. 51 Results . 57 Discussion . 77 Conclusion . 86 REFERENCES . 86 Comprehensive Reference List . Error! Bookmark not defined. Appendix A: Informed consent letter . 111 Appendix B: Interview guide . 113 Appendix C: Ethical Clearance . 115
Rapid method for generating designer algal mitochondrial genomes

With synthetic biology, we can turn algae into bio-factories that produce high-value molecules (e.g. medicines or biofuels) or tackle global challenges (e.g. malnutrition and climate change). This realization has provoked rapid progress towards the creation of genetic tools for multiple algal species, notably Phaeodactylum tricornutum. The power of synthetic biology to generate more useful or productive organisms is contingent on the ability to produce diverse DNA molecules and rapidly screen them for beneficial variants. However, it is still relatively expensive to synthesize DNA, and delivering large DNA (>50 kbp) to eukaryotic cellular compartments remains challenging. In this study, we establish a robust system for building algal mitochondrial genomes as a practical alternative to DNA synthesis. Our approach permits an inexpensive and rapid generation of mitochondrial derivatives designed for testing targeted DNA delivery. First, we cloned the mitochondrial genome of P. tricornutum into the eukaryotic host organism S. cerevisiae using two different techniques: transformation-associated recombination; and PCR-based cloning. Next, we analyzed the cloned genomes by multiplex PCR, and correct genomes were transferred to prokaryotic host E. coli. Then these genomes were again analyzed by multiplex PCR, followed by diagnostic digest and complete-plasmid sequencing to evaluate the fidelity of each cloning method. Finally, we assessed the burden on eukaryotic and prokaryotic hosts to propagate the cloned genomes. We conclude that our system can reliably generate variants for genome-level engineering of algal mitochondria. HIGHLIGHTS TAR-cloned mitochondrial genome of P. tricornutum in yeast Developed PCR-based cloning method to create designer algal mitochondrial genomes Stably propagated algal mitochondrial genomes in S. cerevisiae and E. coli hosts
Arthroscopically Assisted Surgical Treatment of a Calcaneal Bone Cyst in an Athlete

Introduction: Solitary bone cysts are benign, fluid-filled lesions that can occur in the calcaneus. If surgical treatment is necessary, they are most often treated with open surgery with curettage and autologous grafting or bioceramic filling. We report on a unicameral bone cyst (UBC) that was treated arthroscopically.Case Description: An 18-year-old male collegiate football player presented with progressive heel pain for several months. There was tenderness to deep palpation in the posterior plantar hindfoot without sensory and motor deficits. X-rays showed a radiolucent cystic lesion, magnetic resonance image confirmed a cystic structure with low T1 and high-signal T2 intensity with homogenous intensity, and computerized tomography scan and technetium bone scan suggested possible pathologic fracture. Imaging was consistent with a calcaneal bone cyst. Several options were presented and he had minimally invasive curettage and grafting using the arthroscope.Following normal preparation, the lesion was localized under fluoroscopy and an incision was made just distal to the fibular tip. The peroneal tendons were identified and protected and a spinal needle was inserted. Clear fluid was noted and pressure measurement was consistent with a simple cyst. Contrast was injected showing a unicameral space. Biopsy was performed using a trephine and intraoperative pathology confirmed the lesion was a UBC. Using the two-portal technique, the cavity was sequentially curetted using the arthroscope and a second portal for visualization. Using fluoroscopic guidance, it was meticulously debrided with arthroscopic curettes and pituitary rongeurs before being lavaged with multiple liters of fluid. Bleeding cancellous surfaces were noted throughout the bone cavity, then the cavity was packed with morselized cortical cancellous graft and demineralized bone allograft. At 12 months follow-up, physical exam and x-ray examination showed that it was well-healed.Conclusion: This minimally invasive form of treatment may have advantages over open curettage and warrants further study and consideration.
De quelles façons l'intelligence artificielle se sert-elle des neurosciences ?

L'Intelligence Artificielle (IA) s'est construite sur une opposition entre connaissances et donnees. Les neurosciences ont fourni des elements confortant cette vision mais ont aussi revele que des proprietes importantes de notre cognition reposent sur des interdependances fortes entre ces deux concepts. Cependant l'IA reste bloquee sur ses conceptions initiales et ne pourra plus participer a cette dynamique vertueuse tant qu'elle n'aura pas integre cette vision differenciee. IA symbolique et numerique La quete pour l'IA s'est toujours faite sur la base d'une polarite entre deux approches exclusives, symbolique ou numerique. Cette polarite fut declaree des ses origines, avec certains de ses peres fondateurs comme J. von Neumann ou N. Wiener proposant de modeliser le cerveau et le calcul des neurones pour emuler une intelligence, et d'autres comme H. Newell ou J. McCarthy soulignant que, tout comme notre esprit, les ordinateurs manipulent des symboles et peuvent donc construire des representations du monde et les manipulations caracterisques de l'intelligence. Cette dualite est illustree par l'expression des freres Dreyfus « Making a Mind versus Modelling the Brain », dans un article (Dreyfus & Dreyfus, 1991) ou ils expliquent que, par leur construction meme, ces deux paradigmes de l'intelligence sont faits pour s'opposer : Le paradigme symbolique met l'accent sur la resolution de problemes et utilise la logique en suivant une approche reductionniste et le paradigme numerique se focalise sur l'apprentissage et utilise les statistiques selon une approche holistique. On connait la suite de l'histoire avec, tour a tour, chaque approche ecrasant l'autre a l'occasion du succes eclatant d'une technique particuliere, suivi de desillusions entrainant ce que l'on appelle un hiver de l'IA. Aujourd'hui, l'IA a fait des progres indeniables, mais nous subissons toujours cette dualite, meme si le vocabulaire a un peu evolue et que l'on parle maintenant d'IA basee sur les connaissances (pour le web semantique) ou sur les donnees (et les data sciences). Nous sommes actuellement sans conteste dans une periode numerique ou tout le monde n'a que le Deep Learning a la bouche, meme si des voix commencent a s'elever pour predire une chute proche si l'on n'est pas capable d'associer ces techniques numeriques a une interpretabilite (Lipton, 2017), permettant transparence et explications, deux notions du monde des connaissances. Sommes-nous encore partis pour un cycle, a toujours nous demander laquelle de ces deux approches finira par demontrer qu'elle etait la bonne solution, ou saurons-nous sortir du cadre et trancher le noeud gordien ? C'est dans cette derniere perspective que je propose de revenir aux fondamentaux. Puisque les deux approches s'accordent au moins sur le fait qu'elles cherchent a reproduire nos fonctions cognitives superieures, ne devrait-on pas commencer par se demander si notre cognition est symbolique ou numerique ?
A PEDIATRIC MEDULLOBLASTOMA PRESENTING AS AN ISOLATED UNILATERAL SENSORY NEURAL HEARING LOSS

Medulloblastoma is one of the commonest brain tumours in the paediatric population, where they commonly present with increased intracranial pressure related symptoms. We report a child with medulloblastoma who presented with isolated right- sided unilateral sensorineural hearing loss (SNHL) for 4 months prior to diagnosis. He was found to have a large cerebellopontine angle tumour extending to foramen of Luschka and internal auditory canal. Microscopic pathology findings were consistent with medulloblastoma. Based on MEDLINE search and to the best of our knowledge, this paper is the first in the literature of pediatric medulloblastoma presented with isolated unilateral SNHL.
Preparing Counselors to Advocate STEM Careers: A Professional Development Model for K-12 Counselors

Meagan Ross is a Ph.D. student in the College of Engineering Education at Purdue University. She received a B.S. in Computer Science from Texas Woman’s University, and a M.S. in Electrical Engineering from Texas Tech University. Prior to beginning her doctoral studies, she worked as a micro-optoelectromechanical systems engineer for Texas Instruments. Meagan began working for Institute for P-12 Engineering Research and Learning (INSPIRE) in the area of teacher professional development in 2009. Meagan is passionate about providing awareness of engineering to K-12 teachers & counselors so that they can inform and advocate this important career to their students. Her research interests include gender equity in the K-12 Classroom, assessment of K-12 engineering education, curriculum development, and teacher professional development.