Miracle-dz/UniFAR-FTUs huggingface dataset:
Treating the 7,12-dimethylbenz(a)anthracene (DMBA) induced buccal pouch carcinoma in Syrian hamster, Mesocricetus auratus (L) with ethanolic extractives of leaves of mulberry, Morus alba (L).

The leaf extract of mulberry, Morus alba (L) in ethanol was used to treat the 7,12dimethylbenz-anthracene (DMBA) induced carcinoma in the buccal pouch of Syrian hamster, Mesocricetus auratus (L). The 0.5 percent DMBA in liquid paraffin was used for painting the buccal pouch. The DMBA treatment was carried thrice a week for 14 weeks. This was resulted into squamous cell carcinoma. The parameters analyzed include: The tumor incidence, volume and burden. It was followed by oral treatment with ethanolic extractives of mulberry leaves (TpEt) at a dosage of 300 mg/kg, body weight, to DMBA (on alternate days for 14 weeks)painted animals. Administration of ethanolic extractive of mulberry leaves was found preventing significantly the incidence, volume and burden of the buccal pouch carcinoma. The ethanolic extractive of mulberry leaves exhibited significant effect, especially, the antilipidperoxidation and antioxidative enhancement in DMBA individuals of Syrian hamsters. The results are demonstrating the potency of ethanolic extractive of mulberry leaves for chemoprevention and significant antilipidperoxidative influence in 7,12dimethylbenz-anthracene (DMBA)induced carcinoma in the buccal pouch of Syrian hamster, Mesocricetus auratus (L). The activation of caspase through release of cytochrome C through disruption of mitochondrial membrane potential may be the sequence of action of the active principles of mulberry leaf extractives. With it’s bioactive compounds, mulberry, Morus alba (L) may open a World Scientific News 30 (2016) 1-13 -2new avenue in the cancer prevention and treatment. Taken together, the present attempt provide experimental evidence that leaves of mulberry may have chemopreventive effects on cancerous growth. Mulberry, Morus alba (L) may provide a therapeutic option for controlling the growth of cancer cells.
Garo Population of Bangladeshi Hilly Region Possesses Higher Frequency of ACE I / I Genotype in Angiotensin-converting Enzyme-1 ( ACE-1 ) Gene

INTRODUCTION Angiotensin-converting enzyme-1 (ACE-1) plays a major role in the renin-angiotensin system, a system that regulates blood pressure and water balance in mammals. Although ACE has been studied for more than four decades, use of new technologies continues to give new insights into the important role plays in mammalian physiology. ACE is a zinc metallopeptidase that typically cleaves the last two amino acids from its peptide substrates. (1) Bradykinin is one of the well-known substrate of ACE. Accumulations of bradykinin are thought to be responsible for a persistent cough sometimes observed with ACEinhibitor therapy. The ability of ACE to degrade bradykinin positions this enzyme as a common player in both the kinin-kininogen and reninangiotensin systems. Several polymorphisms have been reported in genes of the renin angiotensin system and represent genetic factors that affect both circulating and tissue RAS. These include polymorphisms in the angiotensinogen, ACE, and Angiotensin Receptor genes. The most studied polymorphism is of the insertion/deletion type; the two ACE alleles differ in size because of the insertion of a 287-bp DNA sequence in intron 16 of the ACE gene (Rigat et al., 1990). This ABSTRACT: A common polymorphism in the Angiotensin-converting Enzyme-1 (ACE-1) gene I/D variant have been shown to be associated in the context of physical performance. The present study was undertaken, to determine the frequency of ACE genotype polymorphism in Bengali, Garo and Rakhain populations of Bangladesh. A total of 338 healthy subjects were included in this study, among them 128 were Bengali, 96 were Garo and 114 were Rakhain. DNA was extracted and ACE I/D polymorphism was determined. Data were analyzed using SPSS for windows version 12. BMI of the Garo subjects was significantly lower than the Bengali and Rakhain subjects. Blood pressure of the Garo subjects was significantly higher than the Bengali subjects but lower than the Rakhain subjects. Serum triglyceride and total cholesterol of the Garo subjects were significantly lower than the Bengali subjects. Wild genotype (II) of ACE-1 gene in Garo subjects was significantly higher than the Bengali and Rakhain subjects. Variant genotype in hypertensive subjects of Bengali and Rakhain subjects were significantly higher. From the above results it can be concluded that Garo populations are associated with higher frequency of II genotype in ACE-1 gene and variant genotypes (II and ID) of ACE gene are associated with hypertension in Bengali and Rakhain subjects.
Development of behavior and emotion models for Conbe-I using a Self-Organizing Map learning

We are attempting to develop a robot with a “consciousness” resembling that of a human or an animal in order to enhance an intellectual activity of the robot. In our previous study, we have constructed a model of mechanism of consciousness and behaviors based on the relationship between the action strategies and consciousness levels, this software architecture is called Consciousness-Based Architecture (CBA) module. In addition, the robot should select the behavior and express the emotion by itself, which depends on its surrounding environment. Therefore, in this paper, we have examined the intrinsic motivation and the external situations of robot are used to analyze and classify the behavior and the emotion by a Self-Organizing Map (SOM) that is trained using unsupervised learning, and we attempt to describe the integration of a behavior map and an emotion map into a CBA module. The conscious behavior robot (Conbe-I) has been implemented to show the effectiveness of the proposed system.
Anidulafungin: Review of its Role in the Treatment of Invasive Candidiasis

In 2006 a third echinocandin, anidulafungin, was approved in the USA for the treatment of candida esophagitis, candidemia, and invasive candida infections such as intra-abdominal abscesses and peritonitis in the non-neutropenic patient. Two years later it was approved in the EU for invasive candidiasis in non-neutropenic patients. Like other echinocandins, it is fungicidal against Candida species and fungistatic against Aspergillus species. It does not need adjustment for renal or hepatic insufficiency, and has no known drug interactions. Its administration is by the intravenous route only, and it is well tolerated. A steady state concentration can be achieved on day two by giving twice the maintenance dose on day one.
Effective statistical-based and dynamic fingerprint preprocessing technique

Challenges to contextual filtering techniques include difficulties in estimating orientation field in poor quality images and subsequently failure to extract ridges reliably in large regions of low quality. This study proposes a statistical-based and dynamic fingerprint preprocessing technique for adaptive contrast enhancement and binarisation of fair and poor qualities plain and rolled fingerprints with large regions of low quality, prior to orientation field estimation. The algorithm effectively enhances smudged and faded ridges uniformly in recoverable regions, based on values of statistical variables computed locally in each region. The preprocessing algorithm employs a locally adaptive thresholding approach resulting in enhanced binarised images. The performance of the proposed algorithm was determined by carrying out biometric verification evaluation using a popular commercial biometric matching software, on databases of fingerprints in their original forms, as well as same fingerprints enhanced with the proposed algorithm. Experiments show that fingerprints are uniformly enhanced and binarised; and smudged or faded ridges in recoverable regions made visible. Fingerprint verification evaluation on preprocessed fingerprints resulted in lower error rates in 12 databases. These results show that the proposed algorithm significantly improves recognition.
Fibrin D-Dimer and Cardiovascular Risk

Fibrin D-dimer, the most commonly used clinical assay for detection of coagulation activation and in vivo fibrin formation and lysis in circulating blood, has been associated with risks of cardiovascular diseases in studies published over the past 15 years. This review discusses, in turn, analytic and preanalytic considerations; associations with risk factors; and associations with coronary heart disease, atrial fibrillation, stroke and cerebrovascular disease, peripheral arterial disease, and venous thromboembolism. These associations suggest that activated coagulation and in vivo fibrin formation and lysis may play a role in arterial, intracardiac, and venous thromboembolism. The potential clinical utility of D-dimer in prediction of cardiovascular risk, in indicating patient groups for prophylactic anticoagulation and in monitoring of anticoagulation, requires further study. Harmonization of results from different assays would increase clinical utility.
Interactive visualization toolbox to detect sophisticated android malware

Detecting zero-day sophisticated malware is like searching for a needle in the haystack, not knowing what the needle looks like. This paper describes Android Malicious Flow Visualization Toolbox that empowers a human analyst to detect such malware. Detecting sophisticated malware requires systematic exploration of the code to identify potentially malignant code, conceiving plausible malware hypotheses, and gathering evidence from the code to prove or refute each hypothesis. We describe interactive visualizations of program artifacts to understand and analyze complex Android semantics used by an app. The toolbox incorporates visualization capabilities that work together cohesively, and provides a mechanism to easily add new capabilities. We present case studies of detecting Android malware with confidentiality and integrity breaches. We report the accuracy and efficiency achieved by our team of analysts by using the toolbox, while auditing 77 sophisticated Android apps provided by Defense Advanced Research Projects Agency (DARPA). Toolbox URL·: https://kcsl.github. io/AMFVT/.
Myosin Light Chain Kinase-Dependent Microvascular Hyperpermeability in Thermal Injury

Although the critical role of systemic inflammatory edema in the development of multiple organ failure in patients with massive burns has been fully recognized, the precise mechanisms responsible for the accumulation of blood fluid and proteins in tissues remote from the burn wound are poorly understood. The aim of this study was to test the hypothesis that circulating factors released during thermal injury cause microvascular leakage by triggering endothelial cell contraction and barrier dysfunction. A third-degree scald burn was induced in rats on the dorsal skin covering 25% total body surface area. The microcirculation and transvascular flux of albumin were observed in the rat mesentery using intravital fluorescence microscopy. The direct effect of circulating factors on microvascular barrier function was assessed by measuring the apparent permeability coefficient of albumin in isolated rat mesenteric venules during perfusion of plasma freshly withdrawn from burned rats. The in vivo study showed that the transvenular flux of albumin was significantly increased over a 6-h period with a maximal response seen at 3 h postburn. Importantly, perfusion of noninjured venules with burn plasma induced a time-dependent increase in albumin permeability. Pharmacological inhibition of protein kinase C, Src tyrosine kinases, or mast cell activation did not significantly affect the hyperpermeability response; however, blockage of myosin light chain phosphorylation with the myosin light chain kinase inhibitor ML-7 greatly attenuated the burn-induced increase in venular permeability in a dose-related pattern. The results support a role for endogenous circulating factors in microvascular leakage during burns. Myosin light chain phosphorylation-dependent endothelial contractile response may serve as an end-point effector leading to microvascular barrier dysfunction.
A Survey of Intrusion Detection & Prevention Techniques

Network security is a large and growing area of concern for every network. Most of the network environments keep on facing an ever increasing number of security threats in the form of Trojan worm attacks and viruses that can damage the computer system and communication channels. Firewalls are used as a security check point in a network environment but still different types of security issues keep on arising. In order to further strengthen the network from illegal access the concept of Intrusion Detection System (IDS) and Intrusion Prevention System (IPS) is gaining popularity. IDS is a process of monitoring the events occurring in a computer system or network and analyzing them for sign of possible incident which are violations or imminent threats of violations of computer security policies or standard security policies. Intrusion Prevention System (IPS) is a process of performing intrusion detection and attempting to stop detected possible incidents. This study aims to identify different types of Intrusion Detection and Prevention techniques discussed in the literature.
Oviduct-specific glycoprotein and heparin modulate sperm–zona pellucida interaction during fertilization and contribute to the control of polyspermy

Polyspermy is an important anomaly of fertilization in placental mammals, causing premature death of the embryo. It is especially frequent under in vitro conditions, complicating the successful generation of viable embryos. A block to polyspermy develops as a result of changes after sperm entry (i.e., cortical granule exocytosis). However, additional factors may play an important role in regulating polyspermy by acting on gametes before sperm–oocyte interaction. Most studies have used rodents as models, but ungulates may differ in mechanisms preventing polyspermy. We hypothesize that zona pellucida (ZP) changes during transit of the oocyte along the oviductal ampulla modulate the interaction with spermatozoa, contributing to the regulation of polyspermy. We report here that periovulatory oviductal fluid (OF) from sows and heifers increases (both, con- and heterospecifically) ZP resistance to digestion with pronase (a parameter commonly used to measure the block to polyspermy), changing from digestion times of ≈1 min (pig) or 2 min (cattle) to 45 min (pig) or several hours (cattle). Exposure of oocytes to OF increases monospermy after in vitro fertilization in both species, and in pigs, sperm–ZP binding decreases. The resistance of OF-exposed oocytes to pronase was abolished by exposure to heparin-depleted medium; in a medium with heparin it was not altered. Proteomic analysis of the content released in the heparin-depleted medium after removal of OF-exposed oocytes allowed the isolation and identification of oviduct-specific glycoprotein. Thus, an oviduct-specific glycoprotein–heparin protein complex seems to be responsible for ZP changes in the oviduct before fertilization, affecting sperm binding and contributing to the regulation of polyspermy.
Observation of the Soya Warm Current Combining HF Ocean Radar with Coastal Tide Gauges and Satellite Altimetry

Three HF ocean radar stations were installed at the Soya/La Perouse Strait in the Sea of Okhotsk in order to monitor the Soya Warm Current. The frequency of the HF radar is 13.9 MHz, and the range and azimuth resolutions are 3 km and 5deg, respectively. The radar covers a range of approximately 70 km from the coast. It is shown that the HF radars clearly capture seasonal and short-term variations of the Soya Warm Current. The velocity of the Soya Warm Current reaches its maximum, approximately 1 m s-1, in summer, and weakens in winter. The velocity core is located 20 to 30 km from the coast, and its width is approximately 50 km. The surface transport by the Soya Warm Current shows a significant correlation with the sea level difference along the strait, as derived from coastal tide gauge records. The cross-current sea level difference, which is estimated from the sea level anomalies observed by the Jason-1 altimeter and a coastal tide gauge, also exhibits variation in concert with the surface transport and along-current sea level difference.
Cell-Specific Expression of Homospermidine Synthase, the Entry Enzyme of the Pyrrolizidine Alkaloid Pathway in Senecio vernalis , in Comparison with Its Ancestor, Deoxyhypusine Synthase 1

Pyrrolizidine alkaloids (PAs) are constitutive plant defense compounds with a sporadic taxonomic occurrence. The first committed step in PA biosynthesis is catalyzed by homospermidine synthase (HSS). Recent evidence confirmed that HSS evolved by gene duplication from deoxyhypusine synthase (DHS), an enzyme involved in the posttranslational activation of the eukaryotic translation initiation factor 5A. To better understand the evolutionary relationship between these two enzymes, which are involved in completely different biological processes, we studied their tissue-specific expression. RNA-blot analysis, reverse transcriptase-PCR, and immunolocalization techniques demonstrated that DHS is constitutively expressed in shoots and roots of Senecio vernalis (Asteraceae), whereas HSS expression is root specific and restricted to distinct groups of endodermis and neighboring cortex cells located opposite to the phloem. All efforts to detect DHS by immunolocalization failed, but studies with promoter- b -glucuronidase fusions confirmed a general expression pattern, at least in young seedlings of tobacco ( Nicotiana tabacum ). The expression pattern for HSS differs completely
Redox status of the testes and sperm of rats following exposure to 2,5-hexanedione

Objectives: Exposure to 2,5-hexanedione (2,5-HD) is well known to be associated with reproductive dysfunctions in both humans and animals. However, the role of oxidative stress in 2,5-HD-induced toxicity in testes and sperm has not yet been studied. Methodology: The present study investigated the influence of 2,5-HD on antioxidant systems in the testes and epididymal sperm of rats following exposure to 0, 0.25, 0.5, and 1% 2,5-HD in drinking water for 21 consecutive days. Results: Administration of 0.5% 2,5-HD significantly (P < 0.05) decreased epididymis weight, whereas 1% 2,5-HD-treated rats showed significantly decreased body weight, testis, and epididymis weights compared with the control group. Exposure to 2,5-HD caused a significant dose-dependent increase in the activities of superoxide dismutase, catalase, and glutathione peroxidase in both testes and sperm compared with the control group. Moreover, 2,5-HD-exposed rats showed significant decrease in glutathione-S-transferase activity and glutathione level with concomitant significant elevation in the levels of hydrogen peroxide and malondialdehyde in both testes and sperm. Testicular and epididymal atrophy with significant, dose-dependent, decrease in epididymal sperm number, sperm motility, and viability were observed in 2,5-HD-treated rats. Conclusion: 2,5-HD exposure impaired testicular function and sperm characteristics by disruption of the antioxidant systems and consequently, increased oxidative stress in the treated rats.
New force measurement and micro grasping method using laser Raman spectrophotometer

Force measurement of the micro objects is very important for micromanipulation. For high accuracy, stiffness of the finger tip can be reduced for force measurement. It is not suitable for manipulation. So we consider to evaluate the stress on the micro structure to measure the force. Force measurement based on stress information has advantages when the structure is miniaturized. This can be shown by the scaling analysis. Hence, we propose a new force measurement and micromanipulation method using the laser Raman spectrophotometer (LRS). We design a micro gripper that employs the proposing force measurement method. We show experimental results of force measurement with the analytical evaluation to explain the effectiveness of the proposed system.
Large Scale Agile Adoption Model from Management Perspective

field of software engineering is growing rapidly due to increased change of customers' requirements and progress in technologies. Agile software development (ASD) have substituted the conventional Software development methodologies to enhance the software productivity through short increments and increased user satisfaction. The purpose of this research is to pinpoint the factors (success factors and risk factors) in adopting agile methods for large scale software development team from management perspective. We have adopted systematic literature review (SLR) as a research methodology for the identification of these factors. The expected outcomes of this research will provide input to our proposed model Large Scale Agile Adoption Model (LSAAM) from management perspective. The LSAAM intends to assist the agile experts in managing large team for software development. Keywordssoftware development, success factors, large development team, Systematic literature review.
ASSOCIATION BETWEEN MATERNAL Gm ALLOTYPE AND NEONATAL SEPTICAEMIA WITH GROUP B STREPTOCOCCI

Thirty‐four mothers to infants seriously infected with group B streptococci (GBS) were investigated for Glm(1) and G3m(5) allotype markers. The frequency of Gm(1, ‐5) was 14.7%, of Gm(1, 5) 20.6% and Gm(‐1, 5) 64.7%. There was a marked deficit of Gm(1) individuals and the distribution significantly differed from that in the normal Swedish population.
Randomized comparison of triple therapy and antithymocyte globulin induction treatment after simultaneous pancreas-kidney transplantation.

BACKGROUND The incidence of acute rejection is considered to be higher after simultaneous pancreas-kidney (SPK) transplantation as compared to renal transplant alone. Therefore, the majority of SPK transplant recipients commonly receive a combination of cyclosporine (CsA) or tracolimus, and azathioprine or mycophenolic mofetyl, corticosteroids and/or antilymphocyte preparations. This study was designed to compare two immunosuppressive protocols for the prevention of acute rejection in patients undergoing SPK transplantation. The primary end-point was the incidence of acute rejection during the first 12 months after transplantation METHODS Fifty patients with type-I insulin-dependent diabetes and chronic renal failure were randomized to receive a triple drug immunosuppressive regimen including CsA, azathioprine and corticosteroids (N = 25), or the quadruple sequential combination of rabbit antithymocyte globulin (ATG) given for 10 days, azathioprine, corticosteroids and delayed CsA (N = 25). Maintenance immunosuppression (CsA and azathioprine, without corticosteroids) was similar in both arms. RESULTS The average follow-up was 36 months in both groups (range 9 to 60 months). No patient was excluded from the study. Although the percentage of patients with adverse events was higher in the ATG group (80 vs. 40%, P < 0.01), none of them resulted in premature discontinuation of the drug. Patients receiving ATG experienced a lower incidence (36% vs. 76%, P < 0.01) and number (13 vs. 29, P < 0.05) of acute renal rejection episodes. However, no difference was observed in patient, pancreas and kidney survival rates between groups. No case of isolated pancreas rejection was observed. CONCLUSIONS The quadruple sequential combination ATG, azathioprine, corticosteroid and CsA significantly reduced the one year incidence of acute renal rejection after SPK transplantation, compared to a triple immunosuppressive regimen.