Miracle-dz/UniFAR-FTUs huggingface dataset:
Katey Rayner: Always Asking Questions.

As the youngest of five sisters, Katey Rayner could perhaps have been at risk of being overshadowed. But that never happened. As a child, she was outspoken, always debating, dissecting people’s arguments, and constantly asking, why? In those early days, the endless questioning was a way to rationalize and understand the world. But by the time Rayner was an undergraduate student at the University of Toronto, the questions became more focused: How do diseases happen? What are their molecular pathologies? How can they be treated? Later in her career, Rayner added new, equally important questions: How do I give a talk? How do I write a grant? How do I write an article? These questions were aimed at garnering advice, but not necessarily to follow, she says. Rayner curates advice, essentially polling people to see what’s out there. And this aspect of her character, she insists, helps her achieve her goals and stay one step ahead when making career plans. Rayner is currently the Director of the Cardiometabolic MicroRNA Laboratory at the University of Ottawa Heart Institute, where she and her team investigate how microRNAs contribute to the development of atherosclerosis and how microRNAs may be used to treat cardiovascular diseases in the future.1,2 I grew up in Ottawa, Canada, where I am now. The summers are very hot and the winters are very cold—as a kid, I walked backwards to school because the wind was so cold in my face. But it’s also so snowy and sunny that there are a lot of activities you can do, like skiing and ice-skating, which makes it fun. No. I always really liked school. It was something that came easily to me—I was a typical bookworm. But I wasn’t particularly fascinated with nature. One of the things I always …
Linear generator for direct drive wave energy applications

A 50kW linear permanent magnet generator with a novel topology has been designed and built. The main significance of the generator topology is that there is no attractive force between the stator and permanent magnet translator. The magnetic force between the magnets is reacted within a self supporting structure. The lack of magnetic forces closing the airgap and the modular nature of the generator topology makes the manufacture and assembly of the generator easier than a conventional iron-cored permanent magnet linear generator. Photos of the manufacturing process are included in this paper. The modeling techniques used to design the generator are described and a summary of the design is presented.
Triadic explanation of public services marketing

Abstract. Although the concept of public service marketing was initially criticized in the marketing literature as confusing, it eventually became widely embraced by marketing scholars. Marketing scholars agreed that by the end of the 1970s there was no longer any serious controversy among marketing scholars about public service marketing concept. However, despite this apparent agreement among marketing academics, public administrators and academics in public administration areas have not unanimously embraced the utility of the concept of public services marketing. Two objectives formed the framework for this study: What are the assumptions, conceptualizations and disciplinary perspectives underlying the public services marketing concept? Can a superior conceptualization(s) be developed which is likely to be acceptable to a larger proportion of public services providers? Paper suggests three alternative conceptualizations of public services marketing. Keywords. Service marketing, Public service, Exchange, Redistribution, Reciprocity. JEL. L30, L31, L33, M30, V31.
High urinary excretion of N‐(pyrrole‐2‐carboxyl) glycine in type II hyperprolinemia

A case report of type II hyperprolinemia in a 5‐year‐old boy and its biochemical investigation is presented. The child has mild developmental delay, recurrent seizures of the grand mal type and EEG alterations. Although this disorder has been recently considered a benign condition, variants accompanied by characteristic symptomatology cannot be fully ruled out. The urinary excretion of high concentrations of N‐(pyrrole‐2‐carboxylic acid)‐glycine conjugate is stressed, since it appears that only one previous report in the literature described this compound in the urine of two patients affected by this disturbance.
Innovative youth engagement

Citation for published version: De Andrade, M, Cooper, K & Samson, K 2017, Innovative youth engagement: Empowerment, co-production and health optimisation (Tobacco-free generation 2034: The Fife Project). in G Hastings & C Domegan (eds), Social Marketing: Rebels with a Cause. 3 edn, Routledge, pp. 357-380. https://doi.org/20.500. 11820/425ae5d3-0d38-4af8-9483-0b4f7fc5c244, https://doi.org/10.4324/9781315648590
Molecular and catalytic properties of Arabidopsis thaliana adenylyl sulfate (APS)-kinase.

A cDNA clone (Atakn1) from Arabidopsis thaliana encoding APS-kinase (EC 2.7.1.25) was investigated for structural and catalytic properties of the gene product. Recombinant his10-AtAkn1 formed PAPS at a Vmax of 7.35 U x mg(-1). The Km for APS was 0.14 microM and for ATP 147 microM. APS caused a severe substrate inhibition (K(i) 4.5 microM). The type of inhibition is uncompetitive with respect to MgATP. High ionic strength and reducing thiols stabilized the enzyme activity. Plant APS-kinase is regulated in vitro by the redox charge with thioredoxin as essential activator. Mutagenesis of a serine in S182C and S182F presumed to be involved in the transfer of the phosphoryl group had no effect upon catalytic activity. Using a yeast two-hybrid system with AtAkn1 as bait, an interacting clone was detected from a cDNA library of A. thaliana cv. Columbia that codes for an APS-kinase iso-form (Atakn2). Complementation of APS-kinase-deficient Saccharomyces cerevisiae met14 showed that AtAkn2 is functionally active as APS-kinase. It was immunologically related to AtAkn1 and presumably represents a plastidal iso-form of the plant APS-kinase gene family.
A pairwise discriminative task for speech emotion recognition

Speech emotion recognition is an important task in human-machine interaction. However, it faces many challenges such as the ambiguity of emotion expression and the lack of training samples. To solve these problems, we propose a novel 'Pairwise discriminative task', which attempts to learn the similarity and distinction between two audios rather than specific labels. In the task, pairwise audios are fed into audio encode networks to extract audio vectors, followed with discrimination networks behind to judge whether audios belong to the same emotion category or not. The system is optimized in an end-to-end manner to minimize the loss function, which cooperates cosine similarity loss and cross entropy loss together. To verify the performance of audio representation vectors extracted from the system, we test them on IEMOCAP database-a common evaluation corpus. We gain 56.33% unweighted accuracy on the test database, which surpasses above 5% compared with traditional end-to-end speech emotion recognition networks.
CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis

The gaseous phytohormone ethylene C2H4 mediates numerous aspects of growth and development. Genetic analysis has identified a number of critical elements in ethylene signaling, but how these elements interact biochemically to transduce the signal from the ethylene receptor complex at the endoplasmic reticulum (ER) membrane to transcription factors in the nucleus is unknown. To close this gap in our understanding of the ethylene signaling pathway, the challenge has been to identify the target of the CONSTITUTIVE TRIPLE RESPONSE1 (CTR1) Raf-like protein kinase, as well as the molecular events surrounding ETHYLENE-INSENSITIVE2 (EIN2), an ER membrane-localized Nramp homolog that positively regulates ethylene responses. Here we demonstrate that CTR1 interacts with and directly phosphorylates the cytosolic C-terminal domain of EIN2. Mutations that block the EIN2 phosphorylation sites result in constitutive nuclear localization of the EIN2 C terminus, concomitant with constitutive activation of ethylene responses in Arabidopsis. Our results suggest that phosphorylation of EIN2 by CTR1 prevents EIN2 from signaling in the absence of ethylene, whereas inhibition of CTR1 upon ethylene perception is a signal for cleavage and nuclear localization of the EIN2 C terminus, allowing the ethylene signal to reach the downstream transcription factors. These findings significantly advance our understanding of the mechanisms underlying ethylene signal transduction.
Telemonitoring in patients with heart failure.

BACKGROUND Small studies suggest that telemonitoring may improve heart-failure outcomes, but its effect in a large trial has not been established. METHODS We randomly assigned 1653 patients who had recently been hospitalized for heart failure to undergo either telemonitoring (826 patients) or usual care (827 patients). Telemonitoring was accomplished by means of a telephone-based interactive voice-response system that collected daily information about symptoms and weight that was reviewed by the patients' clinicians. The primary end point was readmission for any reason or death from any cause within 180 days after enrollment. Secondary end points included hospitalization for heart failure, number of days in the hospital, and number of hospitalizations. RESULTS The median age of the patients was 61 years; 42.0% were female, and 39.0% were black. The telemonitoring group and the usual-care group did not differ significantly with respect to the primary end point, which occurred in 52.3% and 51.5% of patients, respectively (difference, 0.8 percentage points; 95% confidence interval [CI], -4.0 to 5.6; P=0.75 by the chi-square test). Readmission for any reason occurred in 49.3% of patients in the telemonitoring group and 47.4% of patients in the usual-care group (difference, 1.9 percentage points; 95% CI, -3.0 to 6.7; P=0.45 by the chi-square test). Death occurred in 11.1% of the telemonitoring group and 11.4% of the usual care group (difference, -0.2 percentage points; 95% CI, -3.3 to 2.8; P=0.88 by the chi-square test). There were no significant differences between the two groups with respect to the secondary end points or the time to the primary end point or its components. No adverse events were reported. CONCLUSIONS Among patients recently hospitalized for heart failure, telemonitoring did not improve outcomes. The results indicate the importance of a thorough, independent evaluation of disease-management strategies before their adoption. (Funded by the National Heart, Lung, and Blood Institute; ClinicalTrials.gov number, NCT00303212.).
Contribution pour l'amélioration de la robustesse et du bruit de phase des synthétiseurs de fréquences.

Cette etude porte sur les apports de l'automatique dans les systemes integres sur Silicium pour la synthese de radio-frequences de l'ordre du Giga-Hertz avec une purete spectrale optimale. La base des architectures qui realisent cette fonction repose sur celle des boucles a verrouillage de phase (PLL). Ce travail se positionne par rapport aux di erents modeles existants et apporte des ameliorations pour l'etude du bruit de phase et de la robustesse de ces systemes non lineaires avec entre autres un outil pour l'analyse de la stabilite et de la robustesse semi globale. Ces travaux ont permis l'optimisation d'une nouvelle architecture fractionnaire realisee et testee. L'approche systemique propre a l'automatique a aussi permis d'ameliorer les performances des architectures numeriques grâce a un observateur et un controleur robuste de type Hinfini. Leur implementation sur Silicium est rendue possible grâce a des algorithmes qui visent a reduire la surface du circuit.
Power Sector Reform and Corruption: Evidence from Electricity Industry in Sub-Saharan Africa

We analyse the impact of corruption and two key aspects of electricity sector reforms, such as the creation of independent regulatory agencies and private sector participation, on several performance indicators in Sub-Saharan Africa. We find that corruption reduces technical efficiency of the sector and constrains the efforts to increase access to electricity and national income. However, some negative effects are offset where independent regulators are established and privatisation is implemented. Our findings suggest that well-designed reforms not only boost economic performance of the sector, but also reduce the negative effects of macro-level institutional deficiencies, such as corruption, on performance indicators.
Will artificial insemination in pigs become more efficient ?

Artificial insemination (AI) is applied worldwide to commercially breed pigs, with fertility outcomes similar to those of natural mating. However, it is not fully efficient, as only liquid-stored semen is used, with a single boar inseminating about 2,000 sows yearly. Use of liquid semen, moreover, constrains international trade and slows genetic improvement. Research efforts, reviewed hereby, are underway to reverse this inefficient scenario. Special attention is paid to studies intended to decrease the number of sperm used per pregnant sow, facilitating the practical use of sexed frozen-thawed semen in swine commercial insemination programs.
Impact of Vaccines; Health, Economic and Social Perspectives

In the 20th century, the development, licensing and implementation of vaccines as part of large, systematic immunization programs started to address health inequities that existed globally. However, at the time of writing, access to vaccines that prevent life-threatening infectious diseases remains unequal to all infants, children and adults in the world. This is a problem that many individuals and agencies are working hard to address globally. As clinicians and biomedical scientists we often focus on the health benefits that vaccines provide, in the prevention of ill-health and death from infectious pathogens. Here we discuss the health, economic and social benefits of vaccines that have been identified and studied in recent years, impacting all regions and all age groups. After learning of the emergence of SARS-CoV-2 virus in December 2019, and its potential for global dissemination to cause COVID-19 disease was realized, there was an urgent need to develop vaccines at an unprecedented rate and scale. As we appreciate and quantify the health, economic and social benefits of vaccines and immunization programs to individuals and society, we should endeavor to communicate this to the public and policy makers, for the benefit of endemic, epidemic, and pandemic diseases.
Biomarkers in the Diagnosis and Prognosis of Sarcoidosis: Current Use and Future Prospects

Sarcoidosis is a heterogeneous disease in terms of presentation, duration, and severity. Due to this heterogeneity, it is difficult to align treatment decisions. Biomarkers have proved to be useful for the diagnosis and prognosis of many diseases, and over the years, many biomarkers have been proposed to facilitate diagnosis, prognosis, and treatment decisions. Unfortunately, the ideal biomarker for sarcoidosis has not yet been discovered. The most commonly used biomarkers are serum and bronchoalveolar lavage biomarkers, but these lack the necessary specificity and sensitivity. In sarcoidosis, therefore, a combination of these biomarkers is often used to establish a proper diagnosis or detect possible progression. Other potential biomarkers include imaging tools and cell signaling pathways. Fluor-18-deoxyglucose positron emission tomography and high-resolution computed tomography have been proven to be more sensitive for the diagnosis and prognosis of both pulmonary and cardiac sarcoidosis than the serum biomarkers ACE and sIL-2R. There is an upcoming role for exploration of signaling pathways in sarcoidosis pathogenesis. The JAK/STAT and mTOR pathways in particular have been investigated because of their role in granuloma formation. The activation of these signaling pathways also proved to be a specific biomarker for the prognosis of sarcoidosis. Furthermore, both imaging and cell signaling biomarkers also enable patients who might benefit from a particular type of treatment to be distinguished from those who will not. In conclusion, the diagnostic and prognostic path of sarcoidosis involves many different types of existing and new biomarker. Research addressing biomarkers and disease pathology is ongoing in order to find the ideal sensitive and specific biomarker for this disease.
A critique of studies evaluating glyphosate effects on diseases associated with Fusarium spp.

Summary With the large-scale adoption of glyphosate-resistant crops in North America, there are concerns that nontarget microbial populations might be affected by increased frequency of glyphosate use. Stimulation of fungal species associated with crop diseases, including Fusarium spp. , has been observed in laboratory and glasshouse experiments. Although field surveys in Saskatchewan detected positive associations between the incidence of Fusarium head blight and application of glyphosate formulations, few field experiments have been successful at demonstrating a stimulatory effect of glyphosate on crop diseases, including diseases associated with Fusarium spp. Taken at face value, there is little evidence from experimental field trials to support a causative link between glyphosate and crop diseases associated with Fusarium spp. However, we are concerned that the experimental field trials investigating links between glyphosate and Fusarium spp. are not representative of interactions that occur under actual farming conditions. In addition, inadequate consideration may have been given to microbial ecology during the design and maintenance of these experimental field trials. At this time, there is insufficient evidence to prove or disprove a link between glyphosate and crop diseases associated with Fusarium spp. and this area should receive high research priority, given the rapid and widespread increase in glyphosate use.
Paper on Voiced / Unvoiced Classification

This paper presents voiced/unvoiced classification based on various methods like empirical mode decomposition, wavelet, cepstrum, zero crossing rate, short time energy etc and statistical model such as neural network, hidden Markov model (HMM) and Gaussian mixture model (GMM). In most of these techniques the voiced/unvoiced classification is usually perform by means of placing a threshold value with a few acoustic functions say, short time energy, zero crossing rate and so on. The primary trouble is the purpose of effective threshold which impact the type issues performance is likewise comes to a decision the choice of threshold. We have observed that a hybrid technique for the voiced/unvoiced classification can enhance the performance of the existing schemes.
Developing a SERM: Stringent Preclinical Selection Criteria Leading to an Acceptable Candidate (WAY‐140424) for Clinical Evaluation

Abstract: Estrogens are represented by a diverse group of compounds. Within this large family of molecules are tissue‐selective estrogens that have been classified as selective estrogen receptor modulators (SERMs). These compounds are characterized by the fact that they exhibit both estrogen agonist and antagonist activity dependent upon the gene promoter and target tissue being examined. SERMs have been intensively studied over the past decade, especially since one, raloxifene, has been approved for the prevention and treatment of postmenopausal osteoporosis. While not a replacement for hormone replacement therapy (HRT), raloxifene can be an alternative to it and other treatments for osteoporosis. The ideal SERM would provide the positive benefits associated with HRT without the uterine and breast stimulation. Raloxifene does achieve some of the benefits of HRT, specifically on the skeleton and lipid metabolism with no apparent uterine effects, and a potential decreased risk of developing breast cancer associated with raloxifene therapy. However, there are a number of parameters that can be improved. A number of SERMs have been evaluated only to fail in development due to, for the most part, uterine safety issues. In order to develop an improved SERM, a stringent screening process was designed to select compounds that did not stimulate the uterus or breast. At the same time, these new compounds would have a positive impact on the skeleton and lipid metabolism with the additional improvement (over raloxifene) of a neutral effect on hot flashes. Under these strict conditions, WAY‐140424 was developed and, to date, the preclinical pharmacology data have accurately predicted the clinical response demonstrated in phase I and II trials.
Clock gating and clock enable for FPGA power reduction

This paper presents experimental measurements of power consumption using different techniques to turn off part of a system and switch between active and standby modes. The main ideas analyzed are: clock gating, clock enable, and blocking inputs. The laboratory work is described, including the measurement setups and the benchmark circuits. Quantitative measurements in both a 65 nm CMOS Cyclone III and a 45 nm CMOS Spartan 6 FPGAs are presented. The selected circuits used as benchmarks are different type of multipliers. Results of power consumption in active and standby modes are presented and compared.
Design of a Shipboard Outside Communication Network and Its Testbed Using PLC: For Safety Management during the Ship Building Process

For the shipbuilding industry worldwide, work-related accidents at the construction site have been a major concern. Workers at the shipyards are consistently exposed to dangerous environments and their intensity of work is quite high. Considering the complexity of the shipbuilding process, efficient communications between workers are essential in the workplace, but current communication methods, which mostly use wireless technologies, are sometimes limited by the structural blocks, creating shadow areas where the radio bands cannot reach. As a countermeasure, SUNCOM Co., Ltd in the Republic of Korea has developed the PLC-based communication system followed by establishing a test-bed facility in cooperation with SK Telecom Co., Ltd and the Hyundai Heavy Industries Co., Ltd. This system and applied technologies are expected to reduce accidents in the field and be applied for other industries having the same problem, providing an uninterrupted communication environment and safer working conditions. The solution adopted this time can provide mobile communication services inside the ship during shipbuilding, thereby enabling rapid processing of work reports and instructions and fast responses to disaster occurrence, contributing to improvements in work efficiency in shipbuilding yards and ensuring workers’ safety.
Public Relations and the Strategic Use of Transparency

This paper extends the interest of public relations scholars in exploring the conditions for balanced communications between organizations and their stakeholders. To this end, we investigate the concept of transparency. More specifically, we challenge the strategic role and institutionalization of transparency in the context of contemporary corporate communications programs. By providing a subtle and nuanced view of transparency, the paper explains how a more sophisticated perspective on transparency can contribute to the vision of public relations as an essential driver towards a