Miracle-dz/UniFAR-FTUs huggingface dataset:
Periprocedural Management of Patients with Endovascular Treatment of Intracranial Atherosclerotic Disease

Clinical outcome in endovascular therapy of intracranial atherosclerosis with stenting and angioplasty or angioplasty alone is dependent on multiple other factors beside the procedure itself. Preprocedure combined antiplatelet administration of aspirin and clopidogrel and its duration is critical. Preferably, this should be administered 5‐7 days prior to the intended procedure and 90 days after the stent placement is preferred. Anticoagulation during the procedure is implemented routinely in the neurointerventional labs during intracranial intervention, with a goal of activated clotting time between 250 to 300 seconds. The preferred agent is unfractionated heparin as an intravenous bolus of 70‐80 units/kg, without postprocedure reversal in most cases. Control of blood pressure intraprocedure and in the neurointensive care unit to avoid intracranial hemorrhage and hyperperfusion injury is of paramount significance. The preferred blood pressure is not well known, but lowering the blood pressure below the baseline after luminal gain with stenting would be recommended to prevent secondary injury. The use of general anesthesia versus local and monitored awake anesthesia is controversial and there are no data to support one method over another in cases of intracranial atherosclerosis interventional and endovascular therapy. If the patient is cooperative and would be able to tolerate the procedure under awake anesthesia, the latter would provide an immediate assessment of the neurological outcome and feedback from the patient. However, general anesthesia would provide the interventionalist with less movement artifact and less road mapping need and immediate and accurate assessment of the location of the microwire, catheter, and stent.
Towards a Precise Understanding of Service Properties

This thesis addresses the question of what would be a domain independent taxonomy that is capable of representing the non-functional properties of conventional, electronic and web services. We cover all forms of services, as we prefer not to make any distinction between the three forms. Conventional service descriptions, such as newspaper advertisements, are rich in detail, and it is this richness that we wish to make available to electronic and web service descriptions. In a conventional service context, when we ask a service provider for details, perhaps by phoning the service provider, we are seeking ways to assist with decision making. It is this same decision making or reasoning that we wish to be available to electronic services. Historically, services have always been distinguished according to some criteria of a service requestor. Examples are price, payment alternatives, availability and security. We are motivated to ensure that the criteria used to evaluate conventional services are also available for electronic and web services. We believe that the ability to richly and accurately describe services has significant applicability in the areas of electronic service discovery, dynamic service composition, service comparison, service optimisation, and service management. In particular, the increased level of descriptive depth will also facilitate more thorough decision-making by a service requestor. Whilst we acknowledge the importance of service functionality, this thesis is primarily concerned with the non-functional properties of services. A service is not a function alone. It is a function performed on your behalf at a cost. And the cost is not just some monetary price; it is a whole collection of limitations. This thesis is all about these. We believe that to accurately represent any service, a description requires information relating to both the functionality and the associated constraints. We consider these constraints over the functionality of the service to be non-functional properties. We believe that a service description is only complete once the non-functional aspects are also expressed. We undertook a significant analysis of services from numerous domains. From our analysis we compiled the non-functional properties into a series of 80 conceptual models that we have categorised according to availability (both temporal and locative), payment, price, discounts, obligations, rights, penalties, trust, security, and quality. Our motivation is to provide a theoretical basis for automated service discovery, comparison, selection, and substitution. The need to describe a service is analogous with labelling for goods or products. Product labelling occurs for the safety and benefit of purchasers. Why is the same labelling not afforded for the benefit of service requestors?
Early Excision and Grafting of Face and Neck Burns in Patients over 20 Years

&NA; Although excision and grafting of burns has become common and standard, many surgeons have been reluctant to excise and graft face burns. In fact, we could find photographic results at 1 year after grafting of only eight patients in the English literature. We began excision and grafting of face burns in 1979 and presented our first 16 patients in 1986 in this journal. With encouragement from Janzěkovič and Jackson, we continued and have now used essentially the same procedure for more than 20 years in approximately 100 patients and, from this large series, are able to present outcomes. From January of 1979 to May of 1999, we performed excision and grafting on 91 patients with deep face burns. Data were recorded and 35‐mm photographs were obtained throughout the 20‐year period. We reviewed that database and the slide files of these patients. We found 45 patients with complete photographic sets including 1‐year follow‐up. Since, in our opinion, there is no useful, objective measure of appearance, we decided to simply publish all 45 sets of complete photographs, permitting the reader to subjectively form an opinion of the outcome of this procedure. The results are all shown as “full” face burns and two “partial” face burns. We continue to believe that early excision and grafting is indicated for face burns that will not heal within 3 weeks and that the procedure yields results that permit the burn victims to return to society and minimizes the time off work or out of school. (Plast. Reconstr. Surg. 109: 1266, 2002.)
Estudios en las algas "Corallinaceae (Rhodophyta)" de las Islas Canarias: I. Aspectos metodológicos.

En este articulo se describe el metodo para el estudio de las especies de la familia Corallinaceae. Las coralinaceas son recolectadas y fijadas inmediatamente en agua de mar formolada al 4%. Despues del estudio morfologico se seleccionan fragmentos que son descalcificados en liquido de Perenyi o en acido nitrico 0.6 N. Ocasionalmente se utiliza la mezcla de Susa como fijador-descalcificador. Los fragmentos son incluidos en parafina, seccionados en el microtomo a 8 um de grosor, tenidos con hematoxilina eosina o fucsina acida y montados en balsamo de Canada.
Aerodynamic Focusing of Nanoparticles: I. Guidelines for Designing Aerodynamic Lenses for Nanoparticles

Abstract This article describes the challenges in focusing nanoparticles (< 30 nm) into tightly collimated beams, and provide guidelines for designing aerodynamic lens systems for nanoparticles. The major difficulties of focusing nanoparticles arise from their low inertia and high diffusivity. Because of their low inertia, nanoparticles tend to closely follow gas streamlines; their high diffusivities lead to beam broadening and diffusional deposition. We have identified the minimum particle size that can be focused to the axis with a single lens when diffusion is neglected, assuming that the flow is continuum and subsonic. We show that lighter carrier gases are preferred for focusing small particles, and that multiple lenses operating at suboptimal Stokes numbers can be designed to focus particles smaller than was recognized previously. There exists a maximum pressure under which particles can be optimally focused, while particle diffusion and pumping requirements are minimized. Finally, we describe the procedure for designing aerodynamic lens systems for focusing nanoparticles, and present a case study of designing a single aerodynamic lens to focus 5 nm particles.
Autism interventions come of age.

ON THE FAR SIDE OF A ONE-WAY window, a 5-year-old boy with a shock of blond hair arranges colored blocks. When he finishes the task, his teacher praises him, and the boy rushes off to his toys. Similar scenes play out in preschools across the country every day, but this calm episode carries a special significance. Eight weeks earlier, the towheaded boy arrived at the Early Childhood Program at the University of California–Los Angeles (UCLA), Neuropsychiatric Institute and promptly flopped on the floor and screamed. He lashed out, hitting and kicking anyone within range. He yelled “No! ” when teachers asked him to perform simple tasks. He fixated on power cords, spending hours—if allowed—twisting them and plugging them in and pulling them out. Exhausted and exasperated, his parents brought him to UCLA for an autism assessment. They witnessed something astounding. “Parents come in and are amazed the kids can learn,” said Stephany Freeman, PhD, who helps run the program. “It’s like there’s a door in their head and you need to pry it open or else it just stays closed. ” The crowbar that affords such leverage is called applied behavior analysis, a vague term for a specific system developed at UCLA in the 1970s and 1980s by Ivar Lovaas, PhD. Widely modified since, the basic theme is unchanged: children receive intensive instruction and learn “no fail” repetition of individual tasks. If the goal is to put a colored block into a box and the child is unable or unwilling, the teacher will pick up the child’s hand—and put her body on top of his, if need be, to keep him from fleeing—and lead him through the motions. Each trial and its outcome is recorded. When a child can consistently complete a task independently, the next skill is introduced. “It’s certainly not a gentle approach,” said Freeman, as a teacher locks her legs around the back of the 5-year-old’s chair to prevent him from scooting away from the table where they are working. “The best evidence is that if you can get to the children early in the course of the disease, you can have a rather profound impact,” said Thomas Insel, MD, director of the National Institute of Mental Health in Bethesda, Md. “And there are kids—somewhere between 20% and 25% perhaps—for whom you can see a reversal of symptoms and what one could almost call a recovery. ”
Serum Response Factor Is Required for Immediate-Early Gene Activation yet Is Dispensable for Proliferation of Embryonic Stem Cells

ABSTRACT Addition of serum to mitogen-starved cells activates the cellular immediate-early gene (IEG) response. Serum response factor (SRF) contributes to such mitogen-stimulated transcriptional induction of many IEGs during the G0-G1 cell cycle transition. SRF is also believed to be essential for cell cycle progression, as impairment of SRF activity by specific antisera or antisense RNA has previously been shown to block mammalian cell proliferation. In contrast, Srf −/− mouse embryos grow and develop up to E6.0. Using the embryonic stem (ES) cell system, we demonstrate here that wild-type ES cells do not undergo complete cell cycle arrest upon serum withdrawal but that they can mount an efficient IEG response. This IEG response, however, is severely impaired in Srf −/− ES cells, providing the first genetic proof that IEG activation is dependent upon SRF. Also, Srf−/− ES cells display altered cellular morphology, reduced cortical actin expression, and an impaired plating efficiency on gelatin. Yet, despite these defects, the proliferation rates of Srf −/− ES cells are not substantially altered, demonstrating that SRF function is not required for ES cell cycle progression.
Contribution a la valorisation alimentaire de la grenade marocaine (punica granatum l. ) : caracterisation physicochimique, biochimique et stabilite de leur jus frais

Le grenadier (Punica granatum) est adapte aux climats arides et semi-arides d'ou l'interet d'etudier et valoriser ses fruits a cause de l'accentuation des problemes de secheresse qui touchent le Maroc ces dernieres annees. D'un autre cote, la grenade possede de fortes capacites antioxydantes et anti-inflammatoires liees a la presence d'anthocyanes, de tanins et d'acide ellagique qui est utilise en therapeutique pour sa capacite a inhiber la proliferation des cellules cancereuses. Toutefois, le but de ce present travail s'interesse dans un premier temps a la caracterisation physicochimique, l'identification et quantification des polyphenols des jus en utilisant l'HPLC ainsi que l'evaluation de l'activite antioxydante de dix-huit cultivars collectionnes au niveau de l'INRA de Meknes. Cette etude a permis de conclure que les jus ont une forte teneur en polyphenols totaux qui varie entre 1385 to 9476 mg GAE/L. L'etude a montre aussi une variabilite statistiquement significative entre les differents cultivars etudies pour l'ensemble des parametres mesures. Dans la seconde partie, qui traite l'effet de la temperature sur la stabilite des polyphenols et surtout des anthocyanes, il a ete montre que la composition de ces composes diminue apres chaque traitement thermique suite a leurs degradations. Pour la troisieme partie concernant l'etude de l'efficacite des pectinases et des proteases dans les traitements de clarification du jus de grenade. Le traitement par les pectinases a une reduction significative de la turbidite par rapport a la protease. La combinaison de ces deux enzymes donne un bon resultat en terme de reduction de la turbidite. Dans la derniere partie consacree a la modelisation de la croissance microbienne qui consiste a appliquer les modeles mathematiques fournis par la base de donnees ComBase sur le jus de grenade, les resultats obtenus ont montre que a des valeurs minimales de la temperature, pH et l'activite de l'eau assurent une longue duree de vie pouvant aller jusqu'a un mois et que le modele ComBase est securisant en general pour ce type de jus.
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Is Expressed in Normal Skin and Cutaneous Inflammatory Diseases, But Not in Chronically UV-Exposed Skin and Non-Melanoma Skin Cancer

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a member of the tumor necrosis factor family that preferentially induces apoptosis in transformed but not normal cells and that is constitutively expressed in many organs including the skin. In addition to its therapeutic potential, TRAIL might act as a natural guardian eliminating transformed cells at an early stage. Ultraviolet (UV) radiation is not only a potent carcinogen because of its mutagenic effects but also because of its capacity to paralyze natural protection mechanisms, including the tumor suppressor gene p53. Therefore, we studied the effect of UV exposure on the expression of TRAIL in the skin by immunohistochemical analysis. TRAIL and its receptors TRAIL-R1 and TRAIL-R4 were constitutively expressed in normal epidermis and not altered in a variety of inflammatory dermatoses including those associated with interface dermatitis. TRAIL was not altered in biopsies of acute sunburn, polymorphic light eruption, and photoprovocation testing, indicating that acute UV exposure does not affect TRAIL expression. No differences were observed in UV-protected and chronically UV-exposed skin samples of younger adults. In contrast, TRAIL was significantly reduced in chronically UV-exposed skin of elderly individuals. In addition, TRAIL expression was reduced in actinic keratoses and Bowen disease and almost completely lost in basal cell and squamous cell carcinomas. In contrast, keratoacanthomas did not reveal any alterations in TRAIL expression. Taken together, these data indicate that chronic UV exposure in elderly patients results in the loss of TRAIL expression, which might contribute to the increased risk of skin cancer in this population. Down-regulation of TRAIL might represent another example of a natural protection mechanism that is eliminated by chronic UV exposure.
Preservers of the rank of matrices over a field.

In 2001, Li and Pierce characterized the linear operators that preserve the g rank of real matrices. The present paper describes all rank preserving maps F : Mm,n(K) −→ Mm,n(K) of the m×n matrices over an arbitrary field K which are of the form F (ai,j) = (fi,j(ai,j)). The linearity of F is not a priorily assumed, and it turns out that if min{m, n} ≤ 2, then nonlinear rank preserving maps indeed exist. MSC2000: 15A03
Protective effects of 2-deoxy-D-glucose on nephrotoxicity induced by cyclosporine A in rats.

OBJECTIVE This study aims to explore the protective effect mechanism of 2-deoxy-D-glucose on nephrotoxicity of cyclosporin A in vivo. METHOD Renal toxicity of SD rats model induced by CsA was established. Serum creatinine, blood urea nitrogen, urine NAG, GSH and MDA were determined and the histopathological changes of rat renal cortex were observed to explore the protective effects of 2-DG on CsA-induced nephrotoxicity. RESULTS Serum creatinine, BUN and urinary NAG of rats were significantly changed in experimental groups. Pathological results showed that there was obvious renal tubular injury in model group, however, the renal injury was significantly reduced in pre-treated with 2-DG. CONCLUSIONS 2-DG had obvious protective effect on nephrotoxicity especially with high dose. This protective effect could be related to the reduction of ROS induced by CsA. However, 2-DG had no effect on the expression of RIP3.
Unternehmensbewertung und Terminal Value: Operative Planung, Steuern und Kapitalstruktur

Diese Arbeit beschaftigt sich mit dem so genannten Endwert bzw. Terminal Value in der Unternehmensbewertung. Es wird gezeigt, wie angesichts eines sehr langen Zeithorizonts das operative Geschaft eines Unternehmens und dessen Kapitalstruktur geplant werden kann. Ein «one size fits all»-Modell verbietet sich aufgrund jeweils spezifischer Unternehmenssituationen. Deshalb wird das Spektrum plausibler Planungsmodelle auch breit gefachert. Entscheidende Determinanten wie Renditen von Reinvestitionen, Reinvestitionsbetrage, Buchrenditen und Wachstum, sowie Steuerregime (mit personlichen Steuern und Unternehmensteuern) und Finanzierungspolitiken werden theoretisch fundiert analysiert. Dies ist wichtig, da sich die Qualitat und damit die Verteidigungsfahigkeit eines Terminal Value entlang der Plausibilitat seiner okonomischen Annahmen bemisst, die jedoch allzu haufig durch das jeweilige Modell implizit getroffen werden. Aus dem Inhalt: Wie kann das operative Geschaft eines Unternehmens (Aktivseite) und dessen Kapitalstruktur (Passivseite) angesichts eines sehr langen Zeithorizonts geplant werden? - Welchen Einfluss konnen dabei Unsicherheit und Steuern (Unternehmensteuern und personliche Steuern) auf die Bewertung dieser Plane ausuben? - Analyse operativer Planungsmodelle anhand des Phasenbezugs und der einzelnen Planungsparameter Uberschusswachstum, Buchrenditen und Buchwertwachstum sowie Reinvestitionswachstum - Die Grundmodelle der Discounted Cashflow-Ansatze - Die Auswirkungen von Unternehmensteuern auf den Wert der Fremdfinanzierung vor dem Hintergrund alternativer Finanzierungspolitiken und alternativer Abbildungen anhand der Discounted Cashflow-Ansatze - Unternehmensteuern und personliche Steuern.
Noise over water surfaces in Landsat TM images

A coherent pattern of system noise observable on all visible wavebands of Landsat Thematic Mapper images over homogeneous surfaces such as waterbodies is regarded as serious enough to impair visual interpretation and affect image analysis results. The noise is removable using iterative median filtering in the spatial domain, which requires much less processing time than removal by frequency domain Fourier transform. The significance of the error introduced to the images by the noise is evaluated in terms of water quality parameters in the study area, and methods for removal of the noise are described.
Florida Health Care Providers' Knowledge of Folic Acid for the Prevention of Neural Tube Defects

Objectives: The purpose of this study was to determine the impact of an educational program on the knowledge and practice behavior of health care providers regarding folic acid use for the prevention of neural tube defects. Methods: A survey was mailed to selected Florida health care providers to determine baseline knowledge and practice behavior. After a statewide educational program, another mail survey was sent to the same groups of providers to determine the effect of the campaign. Results: Comparison between the two surveys showed a significant increase in knowledge and in the percentage of health care providers who recommended the periconceptional use of folic acid for the prevention of neural tube defects. Providers graduating in 1992 or later were more likely than those graduating before 1992 to have the appropriate knowledge about folic acid use but were less likely to recommend it to their patients. Conclusions: Significant gains were made in increasing knowledge and changing practice behavior among selected Florida health care providers. Regardless of the magnitude of these gains, our data show that some health care providers who have regular contact with women of childbearing age still do not know the recommended doses of folic acid or do not recommend its use. This points toward the need for continued education as well as efforts to modify provider behavior.
[Abnormal origin of the left circumflex coronary artery: clinical, angiographic and prognostic aspects. Apropos of 30 cases].

The object of this study of 30 patients with an anomalous origin of the left circumflex coronary artery was to define the clinical and angiographic features of this condition and to assess its influence on morbidity and survival. The 30 patients were 24 men and 6 women with ages ranging from 29 to 76 years. An anomalous origin of the left circumflex coronary artery should be suspected when two angiographic signs are present: firstly, the visualisation of a spur of opacification in the 30 degrees LAO view of left ventriculography, present in 93% or our patients; secondly, during selective left coronary angiography in the transverse view, an ascular zone is observed where the normal left circumflex artery should be. Confirmation of the diagnosis depends on opacification of the left circumflex arising from the right anterior sinus of Valsalva with a separate (37%) or common (23%) orifice with the right coronary artery or arising from a proximal segment of the right coronary artery/(40%). Five patients (17%) had a significant stenosis of the anomalous left circumflex coronary artery but this was always associated with lesions of the other coronary narrowing was observed. Of these patients, one had electrocardiographic signs of myocardial ischaemia and no other cause apart from the anomalous origin of the left circumflex to explain this ischaemia. The 30 patients were followed up for an average of 6.1 +/- 3.9 years. During this period, 1 cardiac death, 1 infarction, 5 cases of angina, 4 coronary bypass procedures, and 6 coronary angioplasties were observed. Nine patients (30%) had no cardiac event during follow-up. (ABSTRACT TRUNCATED AT 250 WORDS)