Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of epidermal growth factor‐induced invasion by dexamethasone and AP‐1 decoy in human squamous cell carcinoma cell lines

Invasive squamous cell carcinoma (SCC) cells degrade extracellular matrix (ECM) via an extracellular protease cascade that includes urokinase‐type plasminogen activator (uPA), plasmin, and the metalloprotease (MMP) family of collagenases. In this study, treatment of oral SCC cells with epidermal growth factor (EGF) stimulated the cells to invade Matrigel (constructive basement membrane (BM) protein). EGF‐induced cell invasion was inhibited by antibodies to uPA and by synthetic uPA inhibitors. EGF also induced increased expression of uPA and uPA receptor (uPAR) proteins and mRNA, as well as transcription factor activator protein‐1 (AP‐1)–DNA binding. These EGF‐induced changes were inhibited by treatment with dexamethasone (DEX). DEX treatment also stimulated the production of plasminogen activator inhibitor type 1. Moreover, transfection of SCC cells with AP‐1 decoy oligodeoxynucleotides (ODNs) resulted in the suppression of EGF‐induced uPA and uPAR expression and Matrigel invasion. These results suggest that oral SCC cells invade Matrigel mainly through the uPA‐plasmin cascade, which is mediated by the transcription factor AP‐1. The uPA–uPAR interaction is essential for augmenting proteolytic activity and uPAR‐mediated signaling, which ultimately induce motility and invasion. Since DEX inhibits the expression of both uPA and uPAR, it may be a useful treatment for oral SCC. J. Cell. Physiol. 193: 340–348, 2002. © 2002 Wiley‐Liss, Inc.
Temperature dependence of hot-carrier degradation in silicon-on-insulator dynamic threshold voltage MOS transistors

The authors analyze the influence of temperature on hot-carrier degradation of silicon-on-insulator (SOI) dynamic threshold voltage MOS (DTMOS) devices. Both low and high stress gate voltages are used. The temperature dependence of the hot-carrier effects in DTMOS devices is compared with those in SOI partially depleted (PD) MOSFETs. Possible physical mechanisms to explain the obtained results are suggested. This work shows that even if the stress gate voltage is low, the degradation of DTMOS devices stressed at high temperature could be significant.
Healthcare informatics.

The conference provided a forum to showcase the ways emerging information technology can enhance traditional learning and communication for health care practitioners. To set the stage for the articles in this section that focus on conference and partnership technology work, the following piece, which is reprinted from Healthcare Informatics magazine, outlines the potential for the revolution in technology to improve medical practice and professional development. Informatics, as the authors point out in this article, is the broad rubric encompassing information science, everything from data bases to facilitate record keeping to transmission of diagnostic images via the Internet.
Changes in insulin action and GLUT-4 with 6 days of inactivity in endurance runners.

The purpose of this investigation was to determine whether decreased insulin action after 6 days of inactivity in endurance-trained runners was associated with a decrease in skeletal muscle glucose transporter protein levels (GLUT-4) in the gastrocnemius muscle. Seven endurance runners (5 men and 2 women) volunteered to participate in this investigation. All subjects had normal glucose tolerance as determined by the National Diabetes Data Group guidelines. Each individual completed two hyperinsulinemic euglycemic clamps at insulin infusion rates of 15 (LO) and 40 (HI) mU.m-2.min-1, one approximately 18 h after a training bout and the second after 6 days of inactivity (IA). Muscle biopsies for the measurement of GLUT-4 were obtained from the gastrocnemius before each clamp. Glucose disposal rates during the last 30 min of each insulin infusion were significantly reduced after 6 days of IA, averaging 6.45 +/- 1.04 mg.kg fat-free mass (FFM)-1.min-1 before and 4.55 +/- 0.56 mg.kg FFM-1.min-1 after detraining for the LO insulin infusion rate and 13.77 +/- 0.88 mg.kg FFM-1.min-1 before and 11.81 +/- 0.60 mg.kg FFM-1.min-1 after detraining for the HI insulin infusion rate (both P < 0.05), despite the fact that plasma insulin was higher in the inactive state (LO, 19.2 +/- 0.9 microU/ml before and 23.4 +/- 1.5 microU/ml after detraining; HI, 56.0 +/- 2.0 microU/ml before and 61.6 +/- 1.6 microU/ml after detraining; P < 0.05)). Calculated insulin clearance was greater in the trained than in the inactive state (P < 0.03). Muscle GLUT-4 transporter protein after 6 days of IA was reduced by 17.5 +/- 5.4% (P < 0.02). These results demonstrate that 6 days of IA reduces insulin action in endurance-trained runners and suggest that a reduction in muscle GLUT-4 transporter level plays a role in the decrease in glucose disposal rates.
Effect of Surface Charge on the Uptake and Distribution of Gold Nanoparticles in Four Plant Species

Small (6−10 nm) functionalized gold nanoparticles (AuNPs) featuring different, well-defined surface charges were used to probe the uptake and distribution of nanomaterials in terrestrial plants, including rice, radish, pumpkin, and perennial ryegrass. Exposure of the AuNPs to plant seedlings under hydroponic conditions for a 5-day period was investigated. Results from these studies indicate that AuNP uptake and distribution depend on both nanoparticle surface charge and plant species. The experiments show that positively charged AuNPs are most readily taken up by plant roots, while negatively charged AuNPs are most efficiently translocated into plant shoots (including stems and leaves) from the roots. Radish and ryegrass roots generally accumulated higher amounts of the AuNPs (14−900 ng/mg) than rice and pumpkin roots (7−59 ng/mg). Each of the AuNPs used in this study were found to accumulate to statistically significant extents in rice shoots (1.1−2.9 ng/mg), while none of the AuNPs accumulated in the shoots of radishes and pumpkins.
Commentary: The Human Circadian Response to Light-Strong and Weak Resetting

The paper by Beersma and Daan (this issue) offers a reinterpretation of our data on the circadian phase-shifting effect of bright light on humans (Czeisler et al., 1989). In our view, Beersma and Daan misunderstand the mathematical basis of the relationship between type 0 and type I resetting, and inaccurately represent not only our data but the data of other investigators. We have organized our response so as to deal separately with the issues on which we disagree.
Energy-aware fog and cloud interplay supported by wide area software defined networking

The paper focuses on dynamic resource provisioning in an all optical wide area Software Defined Network supporting energy-aware interplay between fog and cloud. The main contribution of this paper is a latencyAware policy for handling fog related traffic. The policy is combined with anycast strategies in order to form a complete approach able to handle fog and cloud traffic simultaneously. The proposed approach was compared with reference solutions with respect to latency of fog related requests, CO2 emission and impact on network performance. It is shown that both latency and carbon footprint may be reduced without significant deterioration of network performance.
Parallelization of Pairwise Alignment and Neighbor-Joining Algorithm in Progressive Multiple Sequence Alignment

Progressive multiple sequence alignment ClustalW is a widely used heuristic method for computing multiple sequence alignment (MSA). It has three stages: distance matrix computation using pairwise alignment, guide tree reconstruction using neighbor-joining and progressive alignment. To accelerate computing for large data, the progressive MSA algorithm needs to be parallelized. This research aims to identify, decompose and implement the pairwise alignment and neighbor-joining in progressive MSA using message passing, shared memory and hybrid programming model in the computer cluster. The experimental results obtained shared memory programming model as the best scenario implementation with speed up up to 12 times.
Quiescent fibroblasts in a cellular model system.

Quiescent fibroblasts are non-dividing cells in a reversible postmitotic state induced by lowering the serum concentration of the medium (e.g. from 10% to 0.3%). Three to seven days after lowering the serum concentration only minor metabolic changes will take place in the cells. During this period the quiescent fibroblasts can be used experimentally in a model system for various periods of time.
Assessing myocardial ischemia, hibernation, and viability: stress echocardiography and nuclear imaging.

DO NUCLEAR IMAGING techniques offer advantages over stress echocardiography in detecting the location and degree of ischemia and in determining the viability of myocardial tissue in patients with angina or myocardial infarction? How should the information from these modalities be used in deciding whether a patient should undergo revascularization? In this installment of Cardiology Dialogues, George A. Beller, MD, a pioneer in the field of nuclear cardiology and Chief of the Cardiovascular Division at the University of Virginia, reviews two challenging cases with Thomas H. Marwick, MD, Director of Cardiac Stress Imaging, Cleveland Clinic Department of Cardiology. The cases illustrate the importance of testing for viable myocardium and the relative merits of these two modalities.
Effectiveness of a violence prevention curriculum among children in elementary school. A randomized controlled trial.

OBJECTIVE To determine if a commonly used violence prevention curriculum, Second Step: A Violence Prevention Curriculum, leads to a reduction in aggressive behavior and an increase in prosocial behavior among elementary school students. DESIGN Randomized controlled trial. SETTING Urban and suburban elementary schools in the state of Washington. PARTICIPANTS Six matched pairs of schools with 790 second-grade and third-grade students. The students were 53% male and 79% white. INTERVENTION The curriculum uses 30 specific lessons to teach social skills related to anger management, impulse control, and empathy. MAIN OUTCOME MEASURES Aggressive and prosocial behavior changes were measured 2 weeks and 6 months after participation in the curriculum by parent and teacher reports (Achenbach Child Behavior Checklist and Teacher Report Form, the School Social Behavior Scale, and the Parent-Child Rating Scale) and by observation of a random subsample of 588 students in the classroom and playground/cafeteria settings. RESULTS After adjusting for sex, age, socioeconomic status, race, academic performance, household size, and class size, change scores did not differ significantly between the intervention and control schools for any of the parent-reported or teacher-reported behavior scales. However, the behavior observations did reveal an overall decrease 2 weeks after the curriculum in physical aggression (P=.03) and an increase in neutral/prosocial behavior (P=.04) in the intervention group compared with the control group. Most effects persisted 6 months later. CONCLUSIONS The Second Step violence prevention curriculum appears to lead to a moderate observed decrease in physically aggressive behavior and an increase in neutral and prosocial behavior in school.
Feature Extraction and Learning for RSSI based Indoor Device Localization

In this paper, we study and experimentally compare two state-of-the-art methods for low dimensional feature extraction, within the context of RSSI ﬁngerprinting for localization. On one hand, we consider Stacked Autoencoders, a prominent example of a deep learning architecture, while on the other hand, we explore Random Projections, a universal feature extraction approach. Experimental results suggest that feature learning has a dramatic impact on the subsequent analysis like location based classiﬁcation.
Climate Change and the Transmission of Vector-Borne Diseases: A Review

This article reviews studies examining the relationship between climate variability and the transmission of vector- and rodent-borne diseases, including malaria, dengue fever, Ross River virus infection, and hemorrhagic fever with renal syndrome. The review has evaluated their study designs, statistical analysis methods, usage of meteorological variables, and results of those studies. The authors found that the limitations of analytical methods exist in most of the articles. Besides climatic variables, few of them have included other factors that can affect the transmission of vector-borne disease (eg, socioeconomic status). In addition, the quantitative relationship between climate and vector-borne diseases is inconsistent. Further research should be conducted among different populations with various climatic/ecological regions by using appropriate statistical models.
AUTOMATIC GENERATION CONTROL SCHEMES IN INTERCONNECTED POWER SYSTEMA CRITICAL SURVEY P .

The main objective of this paper is to present a critical literature review and aimed to highlight the various control and structural aspects of AGC used in multi area interconnected power system. The Artificial Intelligence technology offers many more benefits in the area of nonlinear control problems, particularly when the system is operating over the nonlinear operating range. In addition, this paper work reported in the Automatic Generation Control schemes based on power system models and control strategies are reviewed.
Number Three Developing Natural Pest Control Products for Turf

continued on page 4 The term allelopathy was first introduced in 1937 and refers to biochemical interactions among plants that alters plant growth, including those mediated by microorganisms. Allelopathy, besides including competition for resources among plants, is considered to be an important mechanism of plant interference caused by the addition of plant-produced toxins to the plant environment. Chemicals with allelopathic activity are present in virtually all plants and in most tissues, including leaves, stems, flowers, roots, seeds, and buds. Under appropriate conditions, these chemicals may be released into the environment, generally in the rhizosphere region directly around developing plant roots, in quantities sufficient to affect the growth of neighboring plants. In many cases, allelopathic interactions in the field are difficult to study, since reduction in plant growth can also be caused by competition from surrounding plants for light, nutrients, and water as well as CO 2 . These interference mechanisms are often impossible to separate in field studies, but are well documented under controlled conditions in the laboratory or greenhouse. Black Walnuts One example of a commonly observed allelopathic interaction can be seen across New York State in homeowners’ yards, golf courses and woodlands (see Figure 1). The black walnut tree, Juglans nigra, has been reported for centuries to inhibit plant growth through the production of a potent natural herbicide or allelochemical, juglone. Juglone is a chemical compound produced in the bark and living root system of black walnut trees. Juglone can persist in the soil for several months after removal of a black walnut tree, and causes severe reductions in plant growth to sensitive neighboring species, such as azaleas. Juglone alters plant growth directly through specific metabolic inhibition. Sensitive species include many vegetables crops, woody ornamental shrubs and herbaceous groundcovers. The Ericaceous species, including rhododendrons and azaleas are particularly affected by living black walnuts which release juglone. You may also be familiar with tomatoes which quickly wilt when 1. Natural Pest Control
Antithrombin is as effective as heparin and hirudin to prevent formation of microvascular thrombosis in a murine model

Summary A recently published post-hoc analysis of a trial using high-dose antithrombin (AT) in septic patients (KyberSept) revealed significant reduction of lethality when no concomitant heparin was administered, whereas patients with the combination of heparin and AT did not benefit in terms of survival. Therefore, it seems feasible to study the capability of AT in prevention of microvascular thrombus formation to avoid concomitant application of heparin and AT. Using fluorescence microscopy and a light/dyeinjury mouse ear model, the kinetics of thrombus formation were analyzed quantitatively in vivo upon single iv bolus of saline (control), heparin (100 IU/kg), hirudin (1 mg/kg) or AT (25, 50, 100 or 250 IU/kg) (N=7 animals per group each). In controls, light/dye-injury induced complete thrombotic occlusion in all arterioles and venules studied. Heparin and hirudin prevented thrombotic vessel occlusion in 62% and 43% of arterioles and 11% and 28% of venules. AT-250 was found to be more effective than heparin and hirudin, because thrombus formation was completely banned in all arterioles and venules. AT-100 and AT-50 were also capable of significantly blocking thrombus formation in both arterioles and venules. In blood vessels, which finally clogged, the time for development of complete vessel occlusion was delayed after heparin, hirudin and AT-25, but in particular after AT-50 and AT-100. In conclusion, AT-mediated antithrombotic activity has been characterized in a model of phototoxicity-induced microvascular thrombosis formation, demonstrating thatAT delays and prevents thrombus formation in arterioles and venules at least comparably effective as heparin and hirudin.
A novel phase encoding technique exploting linear or circular polarization

The phase response of an High-Impedance Surface (HIS) to an incident plane wave linearly polarized is employed in order to realize a chipless RFID with phase-only encoding. The encoding is obtained by using stubs of different length applied to each single loop included in the unit cell. The information is encoded in the difference between the TE and TM phase response of the tag. Possible improvements of the proposed structure in terms of increased bit capacitance and robustness are also investigated.
Antigenic structure, evolution and immunobiology of human respiratory syncytial virus attachment (G) protein.

IP: 54.70. 40.11 On: Fri, 07 Dec 2018 06:42:32 Journal of General Virology (1997), 78, 2411–2418. Printed in Great Britain .
Interferon Beta for primary progressive multiple sclerosis.

BACKGROUND This is an updated Cochrane review of the previous version published (Cochrane Database of Systematic Reviews 2009, Issue 1. Art. No.: CD006643. DOI: 10.1002/14651858.CD006643.pub2). Therapeutic trials with ss-interferon in Multiple Sclerosis (MS) have mainly focused on remitting-relapsing multiple sclerosis (RRMS), demonstrating a reduction in relapse rate. However, there is not enough evidence about their efficacy in patients with primary progressive multiple sclerosis (PPMS). OBJECTIVES Identify and summarize the evidence that ss-interferon is beneficial and safe in patients with PPMS. SEARCH STRATEGY We searched the Cochrane MS Group Trials Register (May 2009); The Cochrane Central Register of Controlled Trials (CENTRAL) The Cochrane Library, (2009, Issue 2); MEDLINE (PubMed) (January 1966 to May 2009), EMBASE (January 1974 to May 2009); NICE (January 1999 to May 2009); LILACS (January 1986 to May 2009); Screening of reference lists of all primary studies found; Contact and inquiry of drug manufactures and multiple sclerosis experts. SELECTION CRITERIA Randomized double or single blind, placebo-controlled trials of recombinant ss-interferon in patients with PPMS including trials of MS which report separate outcomes in subgroups of patients with PPMS. DATA COLLECTION AND ANALYSIS Two reviewers independently extracted and assessed trials' quality according to the criteria outlined in The Cochrane Handbook. MAIN RESULTS Of 1777 potential studies evaluated, only two Randomized Control Trials (123 patients) were included. ss-interferon treatment compared to placebo did not show differences regarding the proportion of patients with progression of the disease (RR 0.89, 95% CI 0.55 to1.43), and it was associated with a greater frequency of treatment-related adverse events (RR 1.90, 95% CI 1.45-2.48). One of the trials evaluated the MRI secondary outcome pre-specified in the protocol. This trial showed that at two years the numbers of active lesions on brain MRI scan in ss-interferon arm were significantly lower than in placebo arm (weighted mean difference -1.3, 95% CI -2.15 to -0.45, P = 0.003); also, the number of participants with active lesions was significantly higher in placebo arm vs. ss-interferon arm at two years (RR 0.43, 95% CI 0.22 to 0.86, P = 0.02). AUTHORS' CONCLUSIONS Limited data on the effect of ss-interferon treatment on PPMS exists. Only two single-centre placebo controlled trials of interferon beta have been done. Based on this review, the included studies showed that ss-interferon treatment was not associated with reduced disability progression in PPMS patients. However, the trial population was too small to allow definitive conclusions on the efficacy of ss-interferon therapy in PPMS patients. Larger research studies need to be done in patients with PPMS in order to clarify whether ss-interferon is effective in this population.
A Semi-Matching Based Load Balancing Scheme for Dense IEEE 802.11 WLANs

A load balancing mechanism can adjust the load distribution among access points (APs) and improve resource utilization for dense wireless local area networks (WLANs). In this paper, we propose a semi-matching-based load balancing scheme for the IEEE 802.11 dense WLANs. The proposed scheme runs in a centralized controller. The controller judges whether the load is unevenly distributed according to the collected channel busy time ratio information of the entire network, and triggers the load balancing mechanism accordingly. In order to realize load balancing among APs and maximize the overall network throughput, we model the station to AP association problem as a weighted bipartite graph matching problem and find the optimal semi-matching using the Kuhn–Munkres (K-M) algorithm. Simulation results show that the proposed scheme achieves performance improvement comparing with traditional schemes.
Identification of the Site of Epstein-Barr Virus Persistence In Vivo as a Resting B Cell

Epstein-Barr (EBV) is a powerful immortalizing virus for human B lymphocytes in vitro and is associated with several human neoplasias in vivo. Previously, we have shown that the majority of EBV-infected cells in the peripheral blood of healthy, persistently infected individuals do not express the activated phenotype, e.g., high levels of cell surface CD23 and CD80 (B7), characteristically expressed on in vitro-immortalized cells. Here, we show that > or = 90% of the CD23-, virus-infected cells in the peripheral blood are in G0 and therefore resting. The remaining cells may be G1 arrested, but we were unable to detect a significant number of cells traversing the S-G2-M stages of the cell cycle. The mRNA for LMP2A, but not EBNA1 originating from Qp, was readily detected in this population, and these cells appear competent in the processing and presentation of antigen by class I major histocompatibility complex. We propose that these resting B cells are the site of long-term latent persistence for EBV. We further propose that the persistence of the virus in a resting B7- B cell provides an important mechanism to escape immunosurveillance. The demonstration that EBV can persist latently in a resting B cell means that the immortalizing functions of EBV can be down regulated in a normal B cell. This conclusion has important implications for understanding and controlling EBV-associated neoplasia.