Miracle-dz/UniFAR-FTUs huggingface dataset:
New classification for neurodevelopmental disorders in DSM-5.

Correspondence to James C. Harris, MD, Director Developmental Neuropsychiatry, Professor of Psychiatry and Behavioral Sciences, Pediatrics, Mental Health, and History of Medicine, The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, 12th Floor, Charlotte R. Bloomberg Children’s Center, 1800 Orleans Street, Baltimore, MD 21287, USA. Tel: +1 410 614 2401; fax: +1 410 955 8691; e-mail: jharrisd@jhmi.edu
On the origin of cardiac pain. A new hypothesis.

Current theory states that cardiac pain arises when myocardial anoxia stimulates cardiac nerve endings. Discrepancies between facts and this theory were reviewed by James, 1 who points out that "even in those patients with proved coronary disease and classical angina pectoris, the true pathophysiologic basis remains a mystery. " The accepted theory has these drawbacks: (1) it does not explain why 20% to 60% of myocardial infarctions are painless or silent 2 ; (2) it requires the heart to possess intravisceral sensitivity, unlike any other encapsulated organs with similar innervation; (3) it does not explain the mechanism of noncoronary angina pectoris 3 ; and (4) it does not explain the relief of angina despite closure of grafts (bypass "sham") or without improvement in stress tests or cardiodynamics. 4 My new hypothesis circumvents these difficulties by proposing that myocardial ischemia, necrosis, anoxia, or metabolic derangement lead to abnormal ventricular wall motion, which, coupled with
No association between OGG1 Ser326Cys and risk of basal cell carcinoma.

Skin cancer is the most frequent type of cancer in the Western World, and the strongest known risk factor is exposure to UV light. The high-energy UV-B and UV-C light only constitute a small fraction of the total UV light in sunlight. UV-B and UV-C light induce pyrimidine dimers, which are repaired
The project management of the profit contribution from the customers of mobile virtual private network services

This paper aims to probe into the mobile virtual private network (MVPN) and analyzes the impact of project management on the profit contribution of a case mobile company. An empirical model is constructed based on multiple regressions. The dependent variable is the profit contribution from each of six major corporate customers of MVPN services of the case mobile company; independent variables include the service benefits of MVPN services, whether the preferential price of mobile phone is offered by the case mobile company, the monthly mobile bill discount provided by the case mobile company, and the monthly mobile bill subsidy amount offered by corporations to their employees. The empirical results can establish a core business strategy on customer value proposition and identify the best market segment to enhance the profitability and sustainable growth in order to increase the case mobile company's market competitiveness and business performance.
Prosody for Mandarin speech recognition: a comparative study of read and spontaneous speech

In this paper, we present a comparative study between sponta-neous speech and read Mandarin speech in the context of automatic speech recognition. We focus on analysis and modeling of prosodic features, based on a unique speech corpus that contains similar amounts of read and spontaneous speech data from the same group of speakers. Statistical analysis is carried out on tone contours and duration of syllable and sub-syllable units. Speech recognition experiments are performed to evaluate the effectiveness of different approaches to incorporate prosodic features into acoustic modeling. A key problem being addressed is how to deal with the unvoiced frames where F0 values are unavailable. We apply the technique of Multi-space distribution (MSD) to model partially continuous F0 contours. For spontaneous speech, the tonal-syllable error rate is reduced from the MFCC baseline of 64.8% to 59.4% with the MSD based prosody model. For read speech, the performance improves from 46.0% to 36.4%.
Electric field dependence of optical absorption near the band gap of quantum-well structures.

We report experiments and theory on the effects of electric fields on the optical absorption near the band edge in GaAs/AlGaAs quantum-well structures. We find distinct physical effects for fields parallel and perpendicular to the quantum-well layers. In both cases, we observe large changes in the absorption near the exciton peaks. In the parallel-field case, the excitons broaden with field, disappearing at fields -104 V /cm; this behavior is in qualitative agreement with previous theory and in order-of-magnitude agreement with direct theoretical calculations of field ionization rates reported in this paper. This behavior is also qualitatively similar to that seen with threedimensional semiconductors. For the perpendicular-field case, we see shifts of the exciton peaks to lower energies by up to 2.5 times the zero-field binding energy with the excitons remaining resolved at up to -10 V /cm: This behavior is qualitatively different from that of bulk semiconductors and is explained through a mechanism previously briefly described by us [D. A. B. Miller et al., Phys. Rev. Lett. 53, 2173 (1984)] called the quantum-confined Stark effect. In this mechanism the quantum confinement of carriers inhibits the exciton field ionization. To ·support this mechanism we present detailed calculations of the shift of exciton peaks including (i) exact solutions for single particles in infinite wells, (ii) tunneling resonance calculations for finite wells, and (iii) variational calculations of exciton binding energy in a field. We also calculate the tunneling lifetimes of particles in the wells to check the inhibition of field ionization. The calculations are performed using both the 85:15 split of band-gap discontinuity between conduction and valence bands and the recently proposed 57:43 split. Although the detailed calculations differ in the two cases, the overall shift of the exciton peaks is not very sensitive to split ratio. We find excellent agreement with experiment with no fitted parameters. 15 JULY 19&5
Start-up analysis for differential ring oscillator with even number of stages

The start-up conditions for differential oscillator with an even number of stages are analyzed in this paper. Compared with those that have an odd number of stages, such oscillators may have two stable equilibrium states besides an astable equilibrium state in which the circuits can start to oscillate. To avoid the risk of possible latching up into the stable states, an additional start-up circuit technique is proposed. The proposed circuit should also reduce the start-up time. The theory is further confirmed with the design and fabrication of a 4-stage against 3-stage differential ring VCO's in a PLL clock generator based on a 0. 13µm CMOS process.
α-Tocopherol Plays a Role in Photosynthesis and Macronutrient Homeostasis of the Cyanobacterium Synechocystis sp. PCC 6803 That Is Independent of Its Antioxidant Function1

α-Tocopherol is synthesized exclusively in oxygenic phototrophs and is known to function as a lipid-soluble antioxidant. Here, we report that α-tocopherol also has a novel function independent of its antioxidant properties in the cyanobacterium Synechocystis sp. PCC 6803. The photoautotrophic growth rates of wild type and mutants impaired in α-tocopherol biosynthesis are identical, but the mutants exhibit elevated photosynthetic activities and glycogen levels. When grown photomixotrophically with glucose (Glc), however, these mutants cease growth within 24 h and exhibit a global macronutrient starvation response associated with nitrogen, sulfur, and carbon, as shown by decreased phycobiliprotein content (35% of the wild-type level) and accumulation of the nblA1-nblA2, sbpA, sigB, sigE, and sigH transcripts. Photosystem II activity and carboxysome synthesis are lost in the tocopherol mutants within 24 h of photomixotrophic growth, and the abundance of carboxysome gene (rbcL, ccmK1, ccmL) and ndhF4 transcripts decreases to undetectable levels. These results suggest that α-tocopherol plays an important role in optimizing photosynthetic activity and macronutrient homeostasis in Synechocystis sp. PCC 6803. Several lines of evidence indicate that increased oxidative stress in the tocopherol mutants is unlikely to be the underlying cause of photosystem II inactivation and Glc-induced lethality. Interestingly, insertional inactivation of the pmgA gene, which encodes a putative serine-threonine kinase similar to RsbW and RsbT in Bacillus subtilis, results in a similar increase in glycogen and Glc-induced lethality. Based on these results, we propose that α-tocopherol plays a nonantioxidant regulatory role in photosynthesis and macronutrient homeostasis through a signal transduction pathway that also involves PmgA.
Consequential Constructions in Contemporary European Portuguese: A Contribution

The aim of this study is to provide an integrated description of consequential constructions in European contemporary Portuguese, relating their syntactic, semantic and pragmatic behavior. It will be argued that the discourse segment introduced by the connectives consequentemente , de forma que , dai (que) , de modo que , por isso , assim can be analyzed in terms of a supplement (Huddleston & Pullum 2002), not syntactically integrated with its anchor, but semantically related to it. Semantically, consequential constructions may be paraphrased by causal ones involving an adverbial subordinate clause. But, unlike causal constructions, consequential ones connect two distinct speech acts. The suppression of the consequential connective may trigger two different readings, but it will be argued that, for pragmatic reasons (Levinson 2000), the preferential reading is still the consequential one.
Distributed storage and prediction method for mooring monitoring system

Distributed storage and prediction method of monitoring data for mooring monitoring system is researched. Aiming at the real time requirement of monitoring and prediction for mooring monitoring system, used Hadoop distributed file system to store generous monitoring data, and used Map/Reduce framework to predict monitoring data, which solve the problem of mass data storage in limited memory and time-consuming dynamic prediction. Simulation analysis shows that the distributed data storage and prediction method can solve the problem of massive data storage, and enhance the prediction efficiency of the system, so that mooring monitoring system achieve the design requirements of the system.
Heterotrophic nitrification among denitrifiers

Twelve denitrifying bacteria representing six genera were tested for an ability to nitrify pyruvic oxime heterotrophically. Six of these bacteria exhibited appreciable nitrification activity, yielding as much as 5.8 mM nitrite and little or no nitrate when grown in a mineral salts medium containing 7 mM pyruvic oxime and 0.05% yeast extract. Of the six active bacteria, four (Pseudomonas denitrificans, Pseudomonas aeruginosa, and two strains of Pseudomonas fluorescens) could grow on yeast extract but not pyruvic oxime, one (Pseudomonas aureofaciens) could grow slowly on pyruvic oxime, and one (Alcaligenes faecalis) could apparently grow on pyruvic oxime in the presence of yeast extract but not in its absence. Eight of the twelve bacteria in the resting state could oxidize hydroxylamine to nitrite, and P. aureofaciens was remarkably active in this regard. In general, those denitrifiers active in the nitrification of pyruvic oxime or hydroxylamine or both are abundant in soils. A possible advantage of having nitrification and denitrification capabilities in the same organism is discussed.
Approche directe de L'estimation automatique de L'orientation 3D d'images. (A Direct Approach to Automatic Assessment of 3D Images Orientation)

Recemment, la geomatique grand public s'est emparee de la representation3D des bâtiments. Le besoin d'acquerir des images et de les restituer en3D, sous forme de maquettes parfaitement fideles a la realite, est ainsi devenu immense. On a donc vu, depuis une decennie, se construire des vehicules capables de photographier en stereoscopie des villes entieres, et il a fallu concevoir les algorithmes capables de traiter ces enormes quantites d'images. Tres naturellement, les industriels en charge de ces problemes se sont tournes vers les outils de vision par ordinateur et de robotique, tres bien adaptes aux calculs temps reel, oubliant l'essentiel de l'heritage de la photogrammetrie, orientee quant a elle vers une extreme precision, jugee ici commune une moindre priorite. Neanmoins, les algorithmes publies en vision par ordinateur presentaient de reels defauts lorsqu'ils etaient appliques a des surfaces planes et, manque de chance, ce cas est extremement courant dans des scenes urbaines (les facades …. ). Les recherches menees dans le cadre de cette these ont porte sur la recherche de solutions nouvelles, capables d'exploiter les specificites de telles images : tout d'abord, les travaux ont cherche a accelerer l'orientation relative des images, en tirant benefice des points de fuite figurant dans celles-ci. Pour ce faire, de nouvelles methodes d'extraction automatique de ces points ont ete mises au point, bien plus importantes que celles disponibles jusqu'ici. Ensuite, les recherches ont porte sur les moyens de corriger le defaut evoque precedemment pour les surfaces planes, et de nouveaux algorithmes capables de donner en temps quasi-reel de bonnes solutions d'orientation relative pour de telles scenes ont ete developpes. A cette fin, de nouveaux outils mathematiques ont ete utilises : les bases de Grobner. En rupture complete avec les solutions lineaires habituelles, ils permettent en effet une resolution directe des equations sous leur forme polynomiale. Ils evitent de passer par l'habituelle linearisation, qui necssitait une solution approchee parfois difficile a trouver dans les usages de photogrammetrie terrestre. Finalement, ces travaux ont porte sur des moyens d'accelerer les methodes d'orientation relative en exploitant oppurtunement la connaissance de la direction verticale, obtenue par exemple a l'aide du nouvel algorithme de detection des points de fuite. Au total, la these presentee represente une remise a plat generale des solutions permettant l'orientation et la localisation de tout un ensemble d'images.
Ultra-Dense Heterogeneous Relay Networks: A Non-Uniform Traffic Hotspot Case

Ultra-dense heterogeneous networks (UD-Het- Nets) with non-uniform traffic hotspots are important scenarios for future wireless networks, which, however, impose challenges on efficient framework and algorithm design due to the heavy congestion incurred by massive hotspot users. Considering these challenges, this article first develops a two-layer interference-aware heterogeneous relay network architecture that consists of macro base station networks and ultra-dense relay networks. Particularly, we develop an approach to formulate a QoE-aware optimization problem that enfolds connectivity and delay, both of which are crucial for hotspot users in our framework. Regarding this problem, we further devise a cost-efficient resource allocation algorithm that achieves almost the same performance as the optimal one.
Experimental Inoculation with Human Granulocytic Ehrlichia Agent Derived from High- and Low-Passage Cell Culture in Horses

ABSTRACT We report the successful infection throughout intravenous inoculation with low and high passage of in vitro-grown human granulocytic ehrlichiosis (HGE) agent in horses. Differences in disease severity but not in incubation time, hematological changes, PCR detection, ehrlichial load, seroconversion time, and titer range were noted between horses infected with a low and a high passage of in vitro-grown HGE agent.
Effects of Color Combination and Typography on Identification of Characters Briefly Presented on VDTs

This study examines the effects of text and background color combination and typography of characters on visual performance and visual fatigue of individuals working on a visual display termina] (VDT). Correct percentage of performance, critical fusion frequency, near point of convergence, subjective visual fatigue, and preference ranking of color combinations of 40 participants were collected and analyzed. Color combination had no significant effects on visual performance. Typography significantly affected performance. Aesthetically pleasing but more cluttered characters were detrimental to visual performance. Characters of higher frequency and fewer strokes were identified more accurately. Participants also showed differential preference for color combinations. Red-on-green was ranked inferior to color combinations generally used in computer software. Participants showed no visual fatigue during the VDT work.
Space. Europe's Copernicus offers a daily dose of Earth data.

Early in April, the first of a fleet of environmental monitoring satellites will lift off from Europe9s spaceport in Kourou, French Guiana. The Sentinel-1A satellite is part of a program called Copernicus, which will launch a half-dozen craft over the next 7 years and then send up an identical copy of each to boost data gathering and serve as backups. The result will be the world9s first operational environmental monitoring system, a cousin to the operational meteorological services that have provided weather forecasts for decades. Sensors on the Sentinels will measure the state of the ocean surface and its temperature, monitor changes in land use, and take soundings of the atmosphere9s composition and temperature.
Short term effect of air pollution on mortality in Polish urban populations--what is different?

STUDY OBJECTIVE: To assess, within the multinational European Community funded APHEA project, the relationship between daily ambient air pollution with sulphur dioxide (SO2) and black smoke (BS) and the daily number of deaths from all causes except external, from cardiovascular diseases, and from respiratory diseases taking into account several possible confounding factors. DESIGN: Time series analysis with the application of Poisson regression to the counts of daily number of deaths from selected causes over several years. Data were obtained from the computer files of individual death records in four Polish cities. Criteria developed for all the centres participating in the project were applied to the process of model building. SETTING: Four Polish cities - Cracow (period 1977-89), Lodz (1977-90), Poznan (1983-90), and Wroclaw (1979-89). SUBJECTS: Permanent residents of the cities who died in a city of residence or in a surrounding region during the study period. MAIN RESULTS: There were significant positive associations between mortality from all causes excluding external ones and SO2 and BS in Cracow and in Lodz and between mortality from cardiovascular diseases and SO2 in Cracow alone. In other cities the association was either non-significant or significant but in the opposite direction. No significant positive association was found between respiratory deaths and these pollutants. CONCLUSIONS: Short term effect of air pollution on mortality in Polish urban population cannot be ignored. However, differences observed between the cities suggest that the association may be not so straightforward and therefore there is a need of further studies to identify additional factors that may modify and confound the association.
An analysis of nine proprietary Chinese red yeast rice dietary supplements: implications of variability in chemical profile and contents.

OBJECTIVES Some strains of Chinese red yeast rice, when prepared by solid fermentation, produce compounds called monacolins that inhibit cholesterol production. When used as a dietary supplement to achieve and maintain healthy cholesterol levels, Chinese red yeast rice has significant potential to reduce health care costs and contribute to public health by reducing heart disease risk in individuals with moderate elevations of circulating cholesterol levels. Whereas one proprietary strain of Chinese red yeast rice has been demonstrated to lower cholesterol levels significantly in clinical trials, other strains being sold as Chinese red yeast rice dietary supplements have not undergone similar evaluation. In order to determine whether the results of a clinical trial conducted with one strain of Chinese red yeast rice could be generalized to other preparations of Chinese red yeast rice, nine different commercially available dietary supplements were purchased tested for chemical constituents. DESIGN Monacolins were measured by high performance liquid chromatography (HPLC) that separates the various monacolins in Chinese red yeast rice. Citrinin concentration, a toxic fermentation byproduct, was measured by radioimmunoassay. RESULTS Total monacolin content varied from 0% to 0.58% w/w and only 1 of 9 preparations had the full complement of 10 monacolin compounds. Citrinin was found at measurable concentrations in 7 of the 9 preparations. CONCLUSIONS The findings from clinical trials demonstrating significant and clinically relevant cholesterol reduction using a defined Chinese red yeast rice preparation containing 10 different monacolins cannot be generalized to preparations that do not contain the same levels and profile of monacolins. Standardized manufacturing practices should be established for Chinese red yeast rice sold as a dietary supplement in order ensure equivalence of content of active ingredients in preparations being sold to the public and to limit the production of unwanted byproducts of fermentation such as citrinin. In common with other botanical dietary supplements, the full potential of this product will not be realized until standards for production and labeling of Chinese red yeast rice are further developed.
Avaliação in vitro do efeito de agentes clareadores externos em substrato dental bovino e humano

O objetivo geral deste estudo foi avaliar o efeito de agentes clareadores externos em esmalte dental bovino e humano. Foram avaliados diferentes produtos disponiveis comercialmente para realizacao de clareamento dentario: cremes dentais clareadores e geis de peroxido de carbamida e hidrogenio utilizados na tecnica caseira, supervisionada pelo cirurgiao-dentista. A acao dos cremes dentais clareadores foi avaliada em dois diferentes substratos: esmalte dental humano e bovino. Devido as diferencas nos protocolos de aplicacao dos produtos clareadores e nas metodologias dos estudos, estes foram divididos em tres capitulos: Capitulo 1: Artigo 1: Avaliacao do efeito de diferentes cremes dentais clareadores na rugosidade e topografia superficial de esmalte dentario bovino. Capitulo 2: Artigo 2: Avaliacao do efeito de diferentes cremes dentais clareadores na rugosidade e topografia superficial de esmalte dentario humano. Capitulo 3: Artigo 3: Analise da alteracao de cor, rugosidade e topografia superficial de esmalte dentario bovino submetido a diferentes agentes clareadores caseiros.