Miracle-dz/UniFAR-FTUs huggingface dataset:
ANÁLISIS Y DISEÑO OPTIMIZADO DE DISPOSITIVOS PASIVOS DE MICROONDAS DE BANDA AMPLIA CON GUÍAS DE SECCIÓN TRANSVERSAL ARBITRARIA

La evolucion actual de los sistemas de telecomunicacion se caracteriza por la optimizacion constante en el uso y en el manejo del ancho de banda, para poder ofertar asi el mayor rango posible de servicios a los usuarios y al menor coste posible. El area de los dispositivos pasivos de microondas, tanto en lo que respecta a enlaces terrestres como a las comunicaciones espaciales, no ha sido ajeno a esta evolucion. De hecho, este campo ha experimentado grandes avances en los ultimos anos para poder cumplir con unos requisitos cada vez mas exigentes, lo que ha fomentado la aparicion de nuevos dispositivos e importantes mejoras en los ya existentes. El trabajo desarrollado en esta tesis se enmarca dentro de este contexto, y pretende contribuir a la mejora de los procedimientos de analisis y diseno de aquellos dispositivos pasivos de microondas que deben satisfacer unas especificaciones que abarquen un amplio ancho de banda. Es importane destacar que, conforme avanza la tecnologia, la influencia de estos dispositivos en las prestaciones finales de los sistemas de telecomunicacion es cada vez mas importante. Esta tesis se centra en las tres familias de filtros de microondas en tecnologia de guia onda probablemente mas habituales en la practica: los filtros inductivos, los filtros de modo evanescente y los filtros corrugados. No obstante, muchos de los procedimientos aqui desarrollados y los resultados obtenidos se podrian tambien extender a otros dispositivos pasivos con un gran ancho de banda de operacion. En primer lugar se han implementado una serie de herramientas basadas en tecnicas modales, las cuales permiten realizar el analisis de estos componenetes de una forma extremadamente precisa y eficiente. Para poder ampliar el rango de aplicacion de las tecnicas modales a dispositivos con guias no canonicas, se ha desarrollado a su vez un nuevo procedimiento para obtener con gran rapidez y rigurosidad el espectro modal de guias con una seccion transversal practicamente arbitraria.
La flexion verbale en turc : formes verbales complexes et accord participial

Dans ce travail, nous presentons une etude des formes verbales du turc. Nous avancons l’hypothese que ces formes, a l’exception de celles comportant la marque di pour unique suffixe, sont des formes verbales complexes, malgre leur apparence synthetique.Pour ce faire, nous reprenons l’analyse suggeree initialement par Lees 1962, 1972, qui considere, a partir de l’opposition entre les deux paradigmes d’accord, que les formes verbales du turc, a l’exception de celles en dI, sont des formes composees, voire surcomposees, construites a partir d’un participe et d’un auxiliaire / copule. La prise en compte de l’emploi des formes en (E)r, EcEk et mI? dans les subordonnees, et de la structure des interrogatives en mI, nous permet de confirmer cette hypothese ; en outre, la variation de position de l’accent nous fournit un argument supplementaire en sa faveur.Pour rendre compte de l’aspect synthetique des formes, nous suggerons que la specificite de l’auxiliaire tient au fait qu’il n’est realise que par l’accord au present, ce qui rend compte de l’absence de formes non marquees pour ce temps. De plus, notre analyse permet d’expliquer la variation de sens de certains affixes.Nous etudions ensuite un phenomene propre au turc, a savoir la position de la marque de pluriel au sein des formes verbales. Nous montrons que l’apparente variation positionnelle de cette marque resulte en fait de deux phenomenes distincts : l’existence d’un accord participial, et l’interdiction de realiser deux marques de pluriel au sein d’une forme flechie, qu’elle soit verbale ou nominale. Pour finir, nous integrons notre analyse dans une approche contrastive, reposant sur une comparaison avec le francais d’une part, et avec l’hebreu d’autre part.
A Comparison of Testing Parameters and the Implementation of a Group Sequential Design for Equivalence Studies Using Paired-Sample Analysis

We address the problem of establishing two-sided equivalence using paired-sample analysis of two treatments or two laboratory tests with a binary endpoint. Through real data examples and Monte Carlo simulations, we compare three commonly used testing parameters, namely, the difference of response probabilities, the ratio of response probabilities, and the ratio of discordant probabilities based on score test statistics for constructing equivalence hypothesis tests of paired binary data. We provide suggestions on the choice of these three testing parameters and proper equivalence margins in hypothesis formulation of equivalence testing. In addition, we describe the implementation of a group sequential design in the context of equivalence testing with early stopping to reject, as well as to declare equivalence.
Test data for anomaly detection in the electricity infrastructure

This paper describes a large set of electricity data for the IEEE 24 bus system generated on a test bed that copies the cyber layer of the electricity infrastructure in some detail. This data has been filtered and corrupted with natural noise and a realistic set of failure-induced and attack-induced corruptions. One of the main applications of this data is the development of novel anomaly-detecting techniques, which could play a vital role in the identification and repair of problems in the cyber layer of the electricity infrastructure. To encourage work in this area, this data is made freely available online.
Immune activation and induction of memory: lessons learned from controlled human malaria infection with Plasmodium falciparum

SUMMARY Controlled human malaria infections (CHMIs) are a powerful tool to assess the efficacy of drugs and/or vaccine candidates, but also to study anti-malarial immune responses at well-defined time points after infection. In this review, we discuss the insights that CHMI trials have provided into early immune activation and regulation during acute infection, and the capacity to induce and maintain immunological memory. Importantly, these studies show that a single infection is sufficient to induce long-lasting parasite-specific T- and B-cell memory responses, and suggest that blood-stage induced regulatory responses can limit inflammation both in ongoing and potentially future infections. As future perspective of investigation in CHMIs, we discuss the role of innate cell subsets, the interplay between innate and adaptive immune activation and the potential modulation of these responses after natural pre-exposure.
Time course of low molecular weight proteins in the early kidney transplantation period--influence of corticosteroids.

BACKGROUND Cystatin C (Cys C) is an established new marker of renal function in patients with various renal diseases and in kidney transplantation. However, few data are available for the early post-transplantation period. METHODS Twenty-two patients who underwent renal transplantation (RTx) were evaluated for the kinetics of Cys C from day 0 to 14 in relation to creatinine and beta-2 microglobulin (B2MG). Blood samples were obtained immediately before and after transplantation and on a daily basis thereafter. Serum levels before transplantation (100%) were used to calculate reduction ratios. RESULTS The decrease of the analytes differed considerably: immediately after RTx Cys C declined by 27.3% (P < 0.01). However, after 3 days, on average, all patients showed a significant increase in Cys C levels (15+/-2.5%; P < 0.01). B2MG levels fell quickly by 55.4 and 73.8% after days 1 and 7, respectively, and remained stable thereafter. In contrast, creatinine did not decrease immediately after RTx but fell slowly by 67.5% at the end of the study. Prior to rejection, all analytes showed a similar behaviour. Rejection treatment with high-dose methylprednisolone induced a significant increase in Cys C (+22.8+/-7.9%, P < 0.05), while in parallel, creatinine and B2MG decreased (-12.9+/-3.4 and -8.4+/-6.89%). CONCLUSIONS Corticosteroid treatment for induction of immunosuppression or rejection therapy significantly induces Cys C, but decreases B2MG. Cys C and B2MG are not helpful in establishing the diagnosis of rejection earlier. Thus, our data indicate that Cys C and B2MG testing does not accurately reflect changes in the glomerular filtration rate early after transplantation.
Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease

Summary: Dendritic cells (DCs) are composed of a family of cells, now recognized to be essential for innate and acquired immunity. DCs at mucosal surfaces have a particular capacity to induce the differentiation of regulatory T cells producing interleukin‐10 (IL‐10) and transforming growth factor‐β (TGF‐β) in the steady state (non‐infected, non‐immunized), yet they retain the capacity to induce effector T cells in response to invasive pathogens. This decision between the induction of active immunity and tolerance will depend on the subpopulation of DC involved and the surface receptors engaged during DC activation and T‐cell priming. The local microenvironment will likely play an important role both in defining the DC phenotype and in providing direct signals to responding T cells. Furthermore, DCs in organized mucosal lymphoid tissues preferentially induce the expression of CCR9 and α4β7 on T cells, which results in T‐cell homing to the intestinal lamina propria. Finally, DCs may play an important role in the maintenance of abnormal intestinal inflammation either by driving pathogenic T‐cell responses in mesenteric lymph nodes or by acting to expand or maintain pathogenic T cells locally at sites of inflammation. In this review, a brief discussion of general issues of DC biology that are pertinent to mucosal immunity is followed by a more in‐depth discussion of the phenotype and function of DC populations in the intestine.
Letramento, linguagem e escola / On Literacy, Language and School

RESUMO Neste artigo, propomos uma reflexao sobre as contribuicoes da filosofia da linguagem do Circulo de Bakhtin para a abordagem do conceito de letramentos na escola de educacao basica. O projeto teorico do Circulo, que persegue a superacao do dualismo entre vida e teoria, buscando compreender o vivido como evento, permite pensar as esferas da vida humana como instâncias nas quais se produzem enunciados em que os sujeitos assumem uma posicao, uma atitude responsavel em relacao a vida. O fenomeno do letramento deve ser compreendido, para alem da posse de novas tecnologias do ler e escrever, como a assuncao pelos sujeitos de um posicionamento frente ao mundo. Essa perspectiva traz implicacoes para a abordagem dos letramentos, necessitando considerar, nas praticas pedagogicas, as relacoes de alteridade que se estabelecem entre alunos e professores e como, nessas relacoes, alteram-se os sujeitos e suas perspectivas sobre o que represente ler e escrever na contemporaneidade. PALAVRAS-CHAVE: Linguagem; Interacao; Responsividade; Letramento; Generos do discurso
Sensitivity of the Atlantic Thermohaline Circulation and Its Stability to Basin-Scale Variations in Vertical Mixing

Abstract This study shows that a reduction in vertical mixing applied inside the Atlantic basin can drastically increase North Atlantic Deep Water (NADW) stability with respect to freshwater perturbations applied to the North Atlantic. This is contrary to the notion that the stability of the ocean’s thermohaline circulation simply scales with vertical mixing rates. An Antarctic Intermediate Water (AAIW) reverse cell, reliant upon upwelling of cold AAIW into the Atlantic thermocline, is found to be associated with stable states where NADW is collapsed. Transitions between NADW “on” and “off” states are characterized by interhemispheric competition between this AAIW cell and the NADW cell. In contrast to the AAIW reverse cell, NADW eventually upwells outside the Atlantic basin and is thus not as sensitive to changes in vertical mixing within the Atlantic. A reduction in vertical mixing in the Atlantic weakens the AAIW reverse cell, resulting in an enhanced stability of NADW formation. The results also sugge.
Intuitive Error Resolution Strategies during Robot Demonstration

While robot learning from demonstration comes with great benefits [5], the intuitive interaction between naïve users and robots also poses challenges. For instance, users need to be prevented from causing damage and to be enabled to recover from errors. We studied the error resolution strategies of 28 lay users performing simple assembly tasks via teleoperation of a robotic arm in order to gain insight into the strategies users take. The two most common problems are too much pressure and singularity. Even though users were provided with instructions on how to undo singularity in an instruction video, they did not always recover successfully. In contrast, too much pressure, if noticed, was resolved mostly correctly by lifting the peg or by letting it drop into the hole rather than inserting it. Finally, users were quite clueless about how to resolve self-collision and over-rotation.
Preflucel®: a Vero-cell culture-derived trivalent influenza vaccine

Vaccination is the principal means to reduce the impact of influenza infection. Effective vaccination programs require a reliable and safe production system. Traditionally, influenza vaccines are produced in embryonated chicken eggs. Over the last two decades, new cell culture-derived vaccines have been licensed and manufactured, and other vaccines are still in various phases of development. Vero cells have been used for the development of a wide variety of vaccines including influenza vaccines. Pandemic and avian influenza vaccines derived from Vero cells have been shown to be well tolerated and immunogenic in animal and Phase I–II clinical studies. A Phase III randomized, double-blind, placebo-controlled trial of a trivalent influenza vaccine produced in Vero-cell culture was conducted in 7250 adults aged 18–49 years. Overall protective efficacy for antigenically matched influenza vaccine was 78.5%. The vaccine was well tolerated with no treatment-related serious adverse events and compared favorably with egg-derived vaccines from previous trials. Vero-cell-derived influenza vaccines have the potential to be an important parts of the influenza vaccine strategy, especially if an avian-derived strain becomes predominant or the demand outstrips the capacity of egg-based production systems.
Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience.

PURPOSE T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10% to 15% of newly diagnosed cases of childhood acute lymphoblastic leukemia (ALL). Historically, T-ALL patients have had a worse prognosis than other ALL patients. PATIENTS AND METHODS We reviewed the outcomes of 125 patients with T-ALL treated on Dana-Farber Cancer Institute (DFCI) ALL Consortium trials between 1981 and 1995. Therapy included four- or five-agent remission induction; consolidation therapy with doxorubicin, vincristine, corticosteroid, mercaptopurine, and weekly high-dose asparaginase; and cranial radiation. T-ALL patients were treated the same as high-risk B-progenitor ALL patients. Fifteen patients with T-cell lymphoblastic lymphoma were also treated with the same high-risk regimen between 1981 and 2000. RESULTS The 5-year event-free survival (EFS) rate for T-ALL patients was 75% +/- 4%. Fourteen of 15 patients with T-cell lymphoblastic lymphoma were long-term survivors. There was no significant difference in EFS comparing patients with T-ALL and B-progenitor ALL (P =.56), although T-ALL patients had significantly higher rates of induction failure (P <.0001), and central nervous system (CNS) relapse (P =.02). The median time to relapse in T-ALL patients was 1.2 years versus 2.5 years in B-progenitor ALL patients (P =.001). There were no pretreatment characteristics associated with worse prognosis in patients with T-ALL. CONCLUSION T-ALL patients fared as well as B-progenitor patients on DFCI ALL Consortium protocols. Patients with T-ALL remain at increased risk for induction failure, early relapse, and isolated CNS relapse. Future studies should focus on the identification of and treatment for T-ALL patients at high risk for treatment failure.
Increased expression of guanylate binding protein‐1 in lesional skin of patients with cutaneous lupus erythematosus

Abstract: The large GTPase human guanylate binding protein‐1 (GBP‐1) is a key mediator of angiostatic effects of inflammation and is induced by interferon (IFN)‐α and IFN‐γ in endothelial cells (ECs). The aim of this study was to investigate whether GBP‐1 is a marker of skin lesions in patients with cutaneous lupus erythematosus (CLE). Western blotting revealed that GBP‐1 was in vitro induced by IFN‐α and ‐γ in primary keratinocytes obtained from healthy controls. Moreover, we found that this protein was expressed by keratinocytes and ECs in primary and ultraviolet (UV)‐induced skin lesions from patients with various subtypes of CLE, when compared to non‐lesional skin. No GBP‐1 expression was noted in skin biopsy specimens 24 or 72 h after UV irradiation prior to lesion formation in patients with CLE or in healthy control specimens with or without UV irradiation. Initial findings suggest that GBP‐1 is not expressed in other skin diseases with different inflammatory aetiology, such as atopic dermatitis. We conclude that GBP‐1 expression is closely associated with skin lesions in patients with CLE, suggesting a contribution of GBP‐1 in the pathogenesis of this disease.
Infrequent Presence of Anti-c-Myc Antibodies and Absence of c-Myc Oncoprotein in Sera from Lung Cancer Patients

To clarify the host immune response and explore a new serological marker of lung cancer, we examined serum c-Myc antigens and auto-antibodies against c-Myc in 68 lung cancer patients and 30 healthy volunteers using bacterially synthesized glutathione S-transferase c-Myc fusion proteins and immunoblotting. The detection rate of anti-c-Myc antibodies was 13.2% (9/68) in lung cancer patients and 3.3% (1/30) in healthy volunteers. These anti-c-Myc antibodies were directed toward exon 2 alone (4/68), exon 3 alone (1/68), and both exon 2 and exon 3 (4/68) of c-Myc. Circulating c-Myc antigen was not detected in any individuals with lung cancer and normal controls. Age, sex, performance status, histology, stage, smoking history, and prior treatment of the patients with and without anti-c-Myc antibodies were not significantly different. The low incidence of anti-c-Myc antibodies and c-Myc antigens in peripheral blood suggests that these examinations are not useful in the serological diagnosis of lung cancer.
Fractionated cyclophosphamide added to the IVAP regimen (idarubicin-vincristine-L-asparaginase-prednisone) could lower the risk of primary refractory disease in T-lineage but not B-lineage acute lymphoblastic leukemia: first results from a phase II clinical study.

BACKGROUND AND OBJECTIVE In a prior study, primary resistant acute lymphoblastic leukemia (RES-ALL) was observed in 11 of 176 (6%) adult patients treated with a four drug regimen (IVAP), its incidence being higher in T-cell or Philadelphia (Ph) chromosome/BCR-ABL rearrangement positive ALL cases with a blast cell count >25x10(9)/L (RES-ALL rate 19%, p=0.04). Aiming to minimize this percentage of resistant disease, fractionated cyclophosphamide (f-CY) was then added to the IVAP regimen. DESIGN AND METHODS Study 08-96 was a prospective, collaborative phase II trial carried out at eight general hospital centers specialized in the care of hematologic malignancies. Historical IVAP-treated patients served as a retrospective control group. All consecutive, untreated patients (>15 years) with a diagnosis of ALL or advanced-stage lymphoblastic lymphoma (LBL) were eligible. RES-ALL was defined as the persistence of >5% ALL cells in the bone marrow 28-40 days after the start of the IVAP regimen (idarubicin 10 mg/m(2)/d on days 1 and 2; vincristine 2 mg on days 1, 8 and 15; L-asparaginase 6,000 U/m(2) on alternate days 3 6 from day 8; prednisone 60 mg/m(2)/d on days 1-21). In the new study, two f-CY schedules were sequentially adopted: CY 150 or 75 mg/m(2)/bd, given for 4 consecutive days before IVAP (f-CY 1200 or 600, expressing total CY dose in mg/m(2)). RESULTS Eighty-eight patients were evaluable (age range 15-74 years, blast count 0-240x10(9)/L, 14 T-lineage, 74 B-lineage, 13 Ph/BCR-ABL+). The first 39 patients received the f-CY 1200 schedule, 22 patients received f-CY 600, and the last 27 patients were not given any f-CY. These changes were dictated by the results of interim analyses of the f-CY groups (RES-ALL rate not reduced, myelotoxicity increased). Altogether, compared with the historical IVAP and no f-CY groups, the incidence of RES-ALL was not decreased by the addition of f-CY 1200/600 in B-lineage ALL, regardless of Ph/BCR-ABL expression and blast count. However, none of 14 T-ALL cases in the new study had RES-ALL (8 in f-CY groups, 5 of whom with >25x10(9)/L blast cells), compared to 5/39 (13%, overall) or 4/21 (19%, with >25x10(9)/L blast cells) among the control cases. Owing to small sample size, this difference was not statistically significant. INTERPRETATION AND CONCLUSIONS This preliminary experience suggests that T-ALL may be more sensitive than B-lineage ALL to an early therapy including f-CY. The hypothesis could be tested in a larger clinical trial.
Technical aspects of video-assisted and robotic-assisted thoracoscopic segmentectomy.

Li and co-authors very nicely presented their technique of robot-assisted thoracic surgery (RATS) S6-segmentectomy illustrated by high quality figures (1). They presumably base their approach on the excellent book of Nomori and Okada (2), one of the most important references for open segmentectomy of the lung.
Oxidative stress parameters in fish after subchronic exposure to acetylsalicylic acid.

OBJECTIVES The aim of this study was to investigate the effects of subchronic exposure of juvenile development stages of zebrafish (Danio rerio) to acetylsalicylic acid using selected oxidative stress biomarkers. DESIGN Toxicity test with acetylsalicylic acid was performed according to the OECD Guideline No. 215, fish D. rerio aged 30 days were used. The tested concentrations were 0.004, 0.4, 40, 120 and 250 mg.L-1, duration of the test was 28 days. Products of lipid peroxidation and antioxidant enzymes were determined as the markers of oxidative stress. RESULTS Significantly increased glutathione S-transferase activity was found in fish exposed to acetylsalicylic acid concentrations 40, 120 and 250 mg.L-1. The highest values of glutathione reductase activity were found in the groups exposed to acetylsalicylic acid concentrations 0.4, 40 and 120 mg.L-1. In the group exposed to acetylsalicylic acid concentrations 40 mg.L-1, catalase activity was significantly higher compared to the control group. Significantly higher glutathione peroxidase activity was found in the groups exposed to acetylsalicylic acid concentrations 0.004 and 120 mg.L-1. The concentrations of TBARS were lower in fish exposed to acetylsalicylic acid at all tested concentrations compared to control. CONCLUSION The subchronic exposure of zebrafish to acetylsalicylic acid causes an increase in activity of antioxidant and biotransformation enzymes and a decrease in lipid peroxidation.