Miracle-dz/UniFAR-FTUs huggingface dataset:
The Involvement of GRP78 on Estrogen Signaling in Gastric Cancer

It has been reported that GRP78 is highly expressed in gastric cancer, and it is considered as a marker for cancer progression and chemo-responsiveness, as well as target for cancer therapy. However, its potential role in gastric cancer development and progression is still unclear. Here, we found that GRP78 is highly expressed in tumor specimens from gastric cancer patients, and its expression was positively correlated with histological differentiation of human gastric adenocarcinoma. In addition, treatment gastric cancer SGC7901 cells with low concentration of 17β-Estradiol (E2) increased expressions of GRP78 and estrogen receptor-α 36 (ER-α36), a novel variant of ER-α, which was highly expressed, and its expression was correlated with lymph node metastasis of gastric cancer. Thus, we concluded that GRP78 could be a key player to be involved in the development and progression of gastric cancer that influenced by estrogen signaling.
Cellular ferroelectrets for flexible touchpads, keyboards and tactile sensors

Cellular polypropylene ferroelectrets are flexible and conformable transducer materials with a dominant longitudinal piezoelectric effect. They can be used in a wide range of pressure sensing applications. We present concepts for position sensitive touchpads and keyboards based on piezoelectric materials with a dominant longitudinal piezoelectric effect. As large area electrodes are superimposed onto the ferroelectret and combined with electronics at the edges, complex sensor matrices are avoided. We use a ferroelectretic detector stripe as a model system for the theoretical description of the touchpad and show that this detector can be treated mathematically analogous to a transmission line. We present the solutions of the corresponding differential equations under the appropriate boundary conditions and experimental results that are in agreement to them. For the flexible, ferroelectretic keyboard we use a binary or balanced ternary coding technique profiting from the polarization of the ferroelectret.
Body weight, hematologic findings, and serum and plasma biochemical findings of horses competing in a 48-, 83-, or 159-km endurance ride under similar terrain and weather conditions.

OBJECTIVE To compare physiologic, hematologic, and selected serum and plasma biochemical variables obtained from horses competing in 48-, 83-, or 159-km endurance rides before competition and at the same cumulative distance points. ANIMALS 83 horses. PROCEDURE Weight and rectal temperature measurements and blood samples were obtained from horses before, during, and after 1 of 3 rides conducted on the same day. Plasma protein (PP), lactate, WBC, serum electrolyte, and calcium concentrations; PCV; and creatine kinase (CK) activity were determined. Assessments were made to determine whether any differences among groups, with respect to total distance competed, could be explained by differences in lap speed or conditioning and to investigate the effect of time in transit or on-site prior to competition on results of blood analyses or competition outcome. RESULTS Horses in the 159-km distance group had the lowest preride serum sodium, chloride, bicarbonate, and calcium concentrations. As hours in transit increased, preride PP concentration was significantly greater; serum sodium, chloride, and bicarbonate concentrations were lower; CK activity at 159 km was greater; and horses were more likely to be eliminated. The preride sodium was significantly greater in horses that completed the ride, compared with those eliminated. CONCLUSIONS AND CLINICAL RELEVANCE Among distance groups, distance ridden, speed, level of fitness, and years of experience of horses had little effect on the variables examined. Electrolyte and water supplementation and earlier arrival at the event may be beneficial for horses that are transported long distances to endurance competition.
Accidental identification and navigation system in helmet

Now a days, the number of two wheelers in India has drastically increased to a great extent. Due to which automobile users are undergoing numerous road accidents thereby causing death. The first and the foremost precaution to avoid dea this to protectour head, therefore we go for helmets. Even though helmets are available everywhere we are not using it properly. This system is a special idea which helps to promote the usage of helmet in order to make motorcycle driving safer than before.
The E4F Protein Is Required for Mitotic Progression during Embryonic Cell Cycles

ABSTRACT The ubiquitously expressed E4F protein was originally identified as an E1A-regulated cellular transcription factor required for adenovirus replication. The function of this protein in normal cell physiology remains largely unknown. To address this issue, we generated E4F knockout mice by gene targeting. Embryos lacking E4F die at the peri-implantation stage, while in vitro-cultured E4F−/− blastocysts exhibit defects in mitotic progression, chromosomal missegregation, and increased apoptosis. Consistent with these observations, we found that E4F localizes to the mitotic spindle during the M phase of early embryos. Our results establish a crucial role for E4F during early embryonic cell cycles and reveal an unexpected function for E4F in mitosis.
Efficient Biliary Excretion of Susalimod, Probably via the Bromosulphthalein Carrier, Studied in a Chronic Bile Fistula Model in Dogs

Susalimod is a structural analogue of sulphasalazine, known to be extensively excreted in the bile in various animal species and for inducing bile duct hyperplasia after long‐term treatment of the dog with doses exceeding 25 mg kg−1. In this study local concentrations of susalimod in the bile duct were determined after oral administration in dogs.
Effects of anticholinesterase drugs tacrine and E2020, the 5-HT(3) antagonist ondansetron, and the H(3) antagonist thioperamide, in models of cognition and cholinergic function.

This study presents a comparison between two inhibitors of acetylcholinesterase, tacrine and E2020 (Donepezil), the 5-HT(3) receptor antagonist ondansetron, and the H(3) receptor antagonist thioperamide, in models of cholinergic function and cognition in male, Lister hooded rats. The cognitive tests used were an operant VI20 task, the delayed match to position task (short-term memory) and the 5-choice serial reaction time task (attention). Scopolamine (SCOP) (0.075mg/kg s.c.) was utilised in both the short-term memory and attention tasks to impair performance. Both tacrine (1-30mg/kg) and E2020 (1-10mg/kg) similarly produced overt cholinomimetic signs of likely central origin (hypothermia, tremor), although tacrine produced more profound peripheral cholinomimetic signs (miosis, secretory signs) than E2020. Tacrine (30mg/kg) and E2020 (10mg/kg) reduced the number of reinforcements gained in the VI20 schedule. Similarly, both drugs attenuated the SCOP-impairment models in the short-term memory and attention tasks (1-3mg/kg). Ondansetron (10ng/kg-1mg/kg) and thioperamide (0.2-10mg/kg) failed to elicit overt cholinomimetic signs or influence the number of food reinforcements gained in the VI20 schedule. Neither ondansetron nor thioperamide attenuated the SCOP-induced impairment in either cognitive task. From the present studies, both E2020 and tacrine showed a similar behavioural profile in the models used, although E2020 was about three times more potent. Furthermore, E2020 but not tacrine appeared to show some discrimination in eliciting central and peripheral cholinomimetic signs. The failure of ondansetron and thioperamide to reverse a SCOP-induced deficit in these models is discussed.
Asymmetric oculomotor apraxia, optic ataxia, and simultanagnosia with right hemispatial neglect from a predominantly left-sided lesion of the parieto-occipital area

ABSTRACT Introduction: Bálint’s syndrome involves bilateral damage to the parieto-occipital area. The extent of the effect of unilateral damage on the Bálint’s triad (oculomotor apraxia, optic ataxia, and simultanagnosia) remains unknown. Methods: We examined a 63-year-old, right-handed woman who developed right hemianopia, oculomotor apraxia, optic ataxia, simultanagnosia, and hemispatial neglect (HSN) for the right after a cerebral infarction, with detailed neuropsychological tests, magnetic resonance imaging, and single photon emission computed tomography (SPECT). Results: Neuropsychological examination showed that oculomotor apraxia, optic ataxia, and simultanagnosia were more pronounced in the right hemi-space, probably due to the limited eye movement in the right visual field, whereas HSN was restricted to the right hemi-space. Diffusion-weighted MR images revealed hyperintensity in the left parieto-temporo-occipital region, and several spotty areas of the bilateral frontal and parietal subcortical regions. SPECT revealed hypoperfusion in the left parieto-occipital region and frontal operculum and small areas of the right superior parietal lobule. Conclusions: The case suggests that asymmetric (more pronounced in the right hemi-space) oculomotor apraxia, optic ataxia, and simultanagnosia occur in an extensive lesion of the left parieto-occipital cortices. Although HSN is not a prerequisite for simultanagnosia, the coexistence of HSN aggravates simultanagnosia in the hemi-space opposite the lesion.
[The mid-term results of proximal row carpectomy in the treatment of degenerative wrist joint derangements].

OBJECTIVES We evaluated the mid-term results of proximal row carpectomy (PRC) in patients who underwent treatment for wrist joint derangements. METHODS Nine patients (4 men, 5 women; mean age 38 years; range 23 to 66 years) underwent PRC to relive pain in the wrist joint and to improve motion and grip strength. Indications for surgery were acute transscaphoid-perilunate fracture dislocation in one patient, formerly unreduced perilunate fracture dislocation in one patient, Kienbock's disease in four patients, and scaphoid nonunion associated with scapholunate advanced collapse (SLAC) in three patients. The duration of the symptoms ranged from eight months to 10 years. The results were assessed with the use of pre- and postoperative clinical and radiographic studies, and measurements of active and passive motion, grip strength, and pulp and key pinch strengths. The mean follow-up was 35.4 months (range 13.5 to 72 months). RESULTS Postoperatively, pain relief was achieved in all the patients and no complications were encountered in the early period. One patient with acute transscaphoid-perilunate fracture dislocation developed radiocapitate joint degeneration three years after surgery and underwent total wrist arthrodesis. Compared to the uninvolved side, wrist functions were found adequate with painless motion, except for passive radial deviation which exhibited a significant decrease (p<0.05). Age, sex, and the duration of symptoms did not influence postoperative results. CONCLUSION In selected patients with wrist joint derangement, PRC enables painless and adequate motion and grip strength for daily activities. However, radial styloidectomy seems to be necessary to prevent restriction in radial deviation.
The Role of Acute Decompression and Restoration of Spinal Alignment in the Prevention of Post-traumatic Syringomyelia: Case Report and Review of Recent Literature

Study Design. Case report. Introduction. Acute post-traumatic syringomyelia formation after spinal cord injury has been considered a rare complication. At this writing, most recent reports have surfaced in neurosurgical journals. As an entity, post-traumatic syringomyelia has not been widely appreciated. It has been confused with conditions such as Hansen’s disease or ulnar nerve compression at the cubital tunnel. One study also demonstrated that the occurrence of syrinx is significantly correlated with spinal stenosis after treatment, and that an inadequate reduction of the spine may lead to the formation of syrinx. This reported case describes a patient in whom post-traumatic syringomyelia began to develop 3 weeks after injury, which improved neurologically after adequate decompression. Summary of Background Data. A 30-year-old man sustained a 20-foot fall at work. He presented with a complete spinal cord injury below T4 secondary to a T4 fracture dislocation. The patient underwent open reduction and internal fixation of T1–T8. After 3 weeks, the patient was noted to have ascending weakness in his bilateral upper extremities and some clawing of both hands. Methods. A computed tomography myelogram demonstrated inability of contrast to pass through the T4–T5 region from a lumbar puncture. An incomplete reduction was noted. The canal showed significant stenosis. A magnetic resonance image of the patient’s C-spine showed increased signal in the substance of the cord extending into the C1–C2 area. The patient returned to the operating room for T3–T5 decompressive laminectomy and posterolateral decompression including the pedicles, disc, and posterior aspect of the body. Intraoperative ultrasound monitoring showed a good flow of cerebrospinal fluid past the injured segment. Results. On postoperative day 1, the clawing posture of the patient’s hands was significantly diminished, and the patient noted an immediate improvement in his hand and arm strength. Over the next few days, the patient’s strength in the bilateral upper extremities increased to motor Grade 4/5 on manual testing. A magnetic resonance image 4 weeks after decompression showed significant improvement in the cord diameter and signal. Conclusions. Post-traumatic syringomyelia has not been reported at so early a stage after injury. This disorder is an important clinical entity that must be recognized to prevent potentially fatal or devastating complications. As evidenced by the reported patient and the literature, if this disorder is discovered and treated early, permanent deficit can be avoided. The prevention of post-traumatic syringomyelia requires anatomic realignment and stabilization of the spine without stenosis, even in the case of complete injuries, to maintain the proper dynamics of cerebrospinal fluid flow.
Blockchain-Based Consensus (Keynote)

Distributed consensus (aka Byzantine agreement [Pease, Shostak & Lamport, 1980]) is one of the fundamental problems in fault-tolerant distributed computing and cryptographic protocols. It requires correct participants (parties) to reach agreement on initially held values despite the arbitrary behavior of some of them, with the additional requirement (known as Validity) that if all the correct participants start off with the same value, then that must be the decision value. The problem has been studied extensively in both the unconditional setting (where no assumptions are made about the computational power of the adversary) and the cryptographic setting, and efficient (i.e., polynomial-time) solutions exist tolerating the optimal number of misbehaving parties and running in the optimal number of rounds, on networks with pairwise authenticated channels. In many interesting scenarios, however, such as "peer-to-peer" networks, where parties come and go as they please and there are no prior relations among them, such infrastructure (pairwise authenticated channels, public-key infrastructure) is unavailable, thus raising the question whether anything "interesting" can be achieved. In this talk we answer this question in the affirmative, presenting two new probabilistic consensus protocols based on "proofs of work" (POWs, aka "moderately hard functions," "cryptographic puzzles" [Dwork & Naor, 1992]), the technology underlying Bitcoin, the first and most popular decentralized cryptocurrency to date. (In Bitcoin, POWs are implemented using the SHA-256 cryptographic hash function, by finding preimages that produce values in a given smaller domain.) In more detail, we first extract and analyze the core of the Bitcoin protocol, which we term the Bitcoin backbone, and prove two fundamental properties of its "blockchain" approach which we call "common prefix" and "chain quality. " The consensus protocols can then be built as applications on top of the backbone protocol, with the Agreement and Validity properties following from common prefix and chain quality, respectively. The first protocol works assuming the adversary's hashing power is bounded by 1/3 of the network's total hashing power. The second consensus protocol is more elaborate, relies on the notion of robust transaction ledgers, which capture the essence of Bitcoin's operation as a cryptocurrency, and works assuming the adversary's hashing power is strictly less than 1/2.
Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene.

Protein tyrosine phosphatases (PTPs) mediate the dephosphorylation of phosphotyrosine. PTPs are known to be involved in many signal transduction pathways leading to cell growth, differentiation, and oncogenic transformation. We have cloned a new family of novel protein tyrosine phosphatase-like genes, the Ptpl (protein tyrosine phosphatase-like; proline instead of catalytic arginine) gene family. This gene family is composed of at least three members, and we describe here the developmental expression pattern and chromosomal location for one of these genes, Ptpla. In situ hybridization studies revealed that Ptpla expression was first detected at embryonic day 8.5 in muscle progenitors and later in differentiated muscle types: in the developing heart, throughout the liver and lungs, and in a number of neural crest derivatives including the dorsal root and trigeminal ganglia. Postnatally Ptpla was expressed in a number of adult tissues including cardiac and skeletal muscle, liver, testis, and kidney. The early expression pattern of this gene and its persistent expression in adult tissues suggest that it may have an important role in the development, differentiation, and maintenance of a number of different tissue types. The human homologue of Ptpla (PTPLA) was cloned and shown to map to 10p13-p14.
Gender Dysphoria and Co-Occurring Autism Spectrum Disorders: Review, Case Examples, and Treatment Considerations.

PURPOSE Transgender and gender nonconforming people who fulfill diagnostic criteria for autism spectrum disorders (ASDs) often present to mental health providers with concerns that are distinct from those without ASDs. Gender Dysphoria (GD) and ASDs have been proposed to share etiologic mechanisms and there is evidence that ASDs may be more common in transgender and gender nonconforming people. We explore the impact of ASD characteristics on individual gender identity, expression, and the process of psychotherapy. METHOD The authors present two case studies of high-functioning individuals with ASD and GD diagnoses. RESULTS The limited ability to articulate an inner experience, deficits in Theory of Mind (ToM), along with the intolerance of ambiguity as a manifestation of the cognitive rigidity characteristic of ASDs, may present special difficulties to gender identity formation and consolidation and create challenges in psychotherapy. CONCLUSIONS The authors suggest that ASDs do not preclude gender transition and that individuals with high-functioning ASDs are capable of making informed decisions regarding their medical care and life choices. The authors also consider possible challenges and suggest techniques for assisting such clients in exploring their gender identities.
An interface protection system with power line communication for distributed generators remote control

The aim of this work is to present a narrow band power line communication (NB-PLC) interface protection system (IPS) for distributed generators (DGs); it has been developed according to the current standard CEI 0-21 and the requirements for smart grid applications. For such applications, the new IPSs have to implement new intelligent functions such as remote monitoring and control of DGs and Energy Storage Systems (ESSs) inverters, not only in terms of disconnection but also of voltage regulation and power modulation by the utility control. The main feature of the developed IPS is the ability to interact with both the grid and the DG's and ESS's inverters. In fact, it can communicate with the Utility using a Power Line Communication (PLC) and with the DG's and ESS's inverter via Modbus over RS232 communication.
Effects of cigarette smoking on lung function in adolescent boys and girls.

BACKGROUND Little is known about the sex-specific effects of cigarette smoking on the level and growth of lung function in adolescence, when 71 percent of people in the United States who smoke tried their first cigarette. METHODS We studied the effects of cigarette smoking on the level and rate of growth of pulmonary function in a cohort of 5158 boys and 4902 girls 10 to 18 years of age, examined annually between 1974 and 1989 in six cities in the United States. RESULTS We found a dose-response relation between smoking and lower levels of both the ratio of forced expiratory volume in one second to forced vital capacity (FEB1/FVC) and the forced expiratory flow between 25 and 75 percent of FVC (FEF25-75). Each pack per day of smoking was associated with a 3.2 percent reduction in FEF25-75 for girls (P=0.01) and a 3.5 percent reduction in FEF25-75 for boys (P=0.007). Whereas the FVC level was elevated in smokers, the rate of growth of FVC and FEV1 was reduced. Among adolescents of the same sex, smoking five or more cigarettes a day, as compared with never smoking, was associated with 1.09 percent slower growth of FEV1 per year in girls (95 percent confidence interval 0.70 to 1.47) and 0.20 percent slower growth in boys (95 percent confidence interval, -0.16 to 0.56), and with 1.25 percent slower growth of FEF25-75 per year in girls (95 percent confidence interval 0.38 to 2.13) and 0.93 percent slower growth in boys (95 percent confidence interval, 0.21 to 1.65). Whereas girls who did not smoke reached a plateau of lung function at 17 to 18 years of age, girls of the same age who smoked had a decline of FEV1 and FEF25-75. CONCLUSION Cigarette smoking is associated with evidence of mild airway obstruction and slowed growth of lung function in adolescents. Adolescent girls may be more vulnerable than boys to the effects of smoking on the growth of lung function.
Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study.

Hepatic glycogen concentration was measured in six subjects with insulin-dependent diabetes mellitus (IDDM) and nine weight-matched control subjects using 13C nuclear magnetic resonance spectroscopy during a day in which three isocaloric mixed meals were ingested. The relative fluxes of the direct and indirect (3 carbon units-->-->glycogen) pathways of hepatic glycogen synthesis were also assessed using [1-13C]glucose in combination with acetaminophen to noninvasively sample the hepatic UDP-glucose pool. Mean fasting hepatic glycogen content was similar in the two groups. After each meal, hepatic glycogen content increased, peaking 4-5 h after the meal in both groups. By 11:00 p.m. the IDDM subjects had synthesized only 30% of the glycogen that was synthesized by the control group [IDDM subjects, net increment = 44 +/- 20 (mean +/- SE) mM; control subjects, net increment = 144 +/- 14 mM; P < 0.05]. After breakfast the flux through the gluconeogenic pathway relative to the direct pathway of hepatic glycogen synthesis was 1.7-fold greater in the IDDM subjects (59 +/- 4%) than in the control subjects (35 +/- 4%, P < 0.0003). In conclusion, under mixed meal conditions, subjects with poorly controlled IDDM have a major defect in net hepatic glycogen synthesis and augmented hepatic gluconeogenesis. The former abnormality may result in an impaired glycemic response to counterregulatory hormones, whereas both abnormalities may contribute to postprandial hyperglycemia.