Miracle-dz/UniFAR-FTUs huggingface dataset:
Twelve months of nightly zolpidem does not lead to rebound insomnia or withdrawal symptoms: a prospective placebo-controlled study

Rebound insomnia, worsened sleep when discontinuing use of a hypnotic, is reported in some short-term studies. No study has prospectively assessed, using patient reports or nocturnal polysomnography (NPSG), the likelihood of rebound insomnia with chronic hypnotic use. The objectives of this study was to assess in primary insomniacs the likelihood of experiencing rebound insomnia and a withdrawal syndrome on repeated placebo substitutions over 12 months of nightly zolpidem use. A group of 33 primary insomniacs, without psychiatric disorders or drug and alcohol abuse, 32–65 years old, 15 men and 18 women, were randomized to take zolpidem 10 mg (n = 17) or placebo (n = 16) nightly for 12 months. In probes during months 1, 4, and 12, placebo was substituted for 7 consecutive nights in both the zolpidem and placebo groups. NPSGs were collected and Tyrer Bezodiazepine Withdrawal Symptom Questionnaires were completed on the first two discontinuation nights. Rebound insomnia was not observed on the first two and the seventh discontinuation nights and its likelihood did not increase over the 12 months of nightly zolpidem use. Some individuals did show rebound insomnia, approximately 30–40% of participants, but the percentage of ‘rebounders’ did not differ between the placebo and zolpidem groups and did not increase across 12 months. No clinically significant withdrawal symptoms on the Tyrer were observed on the discontinuation nights over the 12 months of nightly use. Chronic nightly hypnotic use at therapeutic doses by primary insomniacs does not lead to rebound insomnia or withdrawal symptoms.
Wireless Power Link Based on Inductive Coupling for Brain Implantable Medical Devices

An inductively powered brain implantable medical device (BIMD) <italic>in lieu</italic> of a <italic> battery-assisted</italic> BIMD has the ability to provide a reliable power supply and avoid surgical replacement of a discharged battery. In this letter, we propose a three-dimensional (3-D) bowtie implantable antenna embedded in the cerebral spinal fluid (CSF) coupled with an exterior loop antenna. The power transfer efficiency is maximized by designing a matching circuit for the exterior and implantable antennas to reduce the high intrinsic reactive part of the input impedance. To ensure safety for long-term implantation, a rigorous specific absorption rate simulation was conducted to abide with the safety standard. A liquid CSF phantom was developed to experimentally test the power transfer efficiency between the exterior and implantable antenna. Measurement of the fabricated 0.9 <inline-formula><tex-math notation="LaTeX">$\text{mm}^{3}$</tex-math></inline-formula> implantable antenna prototype in the CSF phantom resulted in <inline-formula><tex-math notation="LaTeX">$-\text{30.12 dB}$</tex-math></inline-formula> wireless power link, which outperforms the current work in the literature in terms of the size and link efficiency for 3-D implantable antennas.
A FAST Extreme Illumination Robust Feature in Affine Space

Robust feature plays an important role in many vision based applications. This paper proposes a fast extreme illumination robust feature in affine space. It inherits the techniques of extreme point location and main orientation computation from SIFT (Scale Invariant Feature Transform) algorithm, and adopts the rotation and scale invariant circular binary pattern based histograms in the affine space to generate feature vectors of the extreme points. Based on the binary pattern based histograms, this work maximally improves the illumination robustness in affine space and reduces the processing time. Comparing with the typical work-ASIFT(Affine SIFT) that is characterized by strong robustness on the aspects of viewpoint, scale, rotation and illumination, this work improves the robustness for the extreme illumination change in the affine space while maintains the comparable detection performance on the other aspects, and achieves the average 82.6 times improvement on the processing time.
Manganese intoxication in the rhesus monkey

We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximate 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopa test if the animal developed features of basal ganglia dysfunction. After the animals were killed, we performed neuropathologic, neurochemical, and laser microprobe mass analysis (LAMMA) studies. Two of three animals developed a parkinsonian syndrome characterized by bradykinesia, rigidity, and facial grimacing suggestive of dystonia but not tremor. Neither animal responded to levodopa. Autopsy demonstrated gliosis primarily confined to the globus pallidus (GP) and the substantia nigra pars reticularis (SNr). We detected focal mineral deposits throughout the GP and SNr, particularly in a perivascular distribution. LAMMA studies noted that mineral deposits were primarily comprised of iron and aluminum. The severity of pathologic change correlated with the degree of clinical dysfunction. These studies demonstrate that, in contrast to Parkinson's disease (PD) and MPTP-induced parkinsonism, manganese primarily damages the GP and SNr and relatively spares the nigrostriatal dopaminergic system. Further, the results suggest that Mn-induced parkinsonism can be differentiated from PD and MPTP-induced parkinsonism by the clinical syndrome and response to levodopa. The accumulation of iron and aluminum suggests that iron/aluminum-induced oxidant stress may contribute to the damage associated with Mn toxicity. NEUROLOGY 1996,46 492-498
A Middleware Architecture for Wireless Sensor Networks Using Secure Web Services

This paper proposes a service oriented middleware architecture for wireless sensor networks (WSNs) with security requirements. The web services standards XML, SOAP and WSDL are used for network communication. For the WSN security the WS-Security specification is applied, using cryptography and authentication for the data traffic. A prototype developed in Java language tests the proposed architecture. The results obtained show the correct functioning of the middleware, which facilitates the development of secure applications for WSNs.
Quality of life of long-term survivors of non-small-cell lung cancer.

PURPOSE To describe the quality of life (QOL) among survivors of non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS One hundred forty-two 5-year minimum self-reported disease-free survivors of NSCLC completed QOL instruments (QOL-Survivor and Medical Outcomes Study 36-Item Short Form [SF-36]) and assessments of emotional distress (Center for Epidemiologic Studies Depression Scale [CES-D]), comorbid disease, and tobacco use. Pulmonary function was assessed with a hand-held spirometer. Multivariate regression methods were used on total QOL-Survivor scores and physical (PC) and mental (MC) component scores of the SF-36. RESULTS The majority (71%) of survivors described themselves as hopeful, and 50% viewed the cancer experience as contributing to positive life changes (QOL-Survivor). Comorbidity was common (60% >or= one condition); 22% had distressed mood (CES-D >or= 16). Most were former smokers (76%); 13% continued to smoke. Half had moderate/severe pulmonary distress (forced expired volume in 1 second [FEV1] < 70% of predicted). Regression models including the set of variables (age, sex, living alone, education, smoking status, pulmonary function category, distressed mood, time since diagnosis, and comorbidity) accounted for 37%, 48%, and 29% in the QOL-total, MC, and PC scores, respectively. Primary predictors of lower QOL scores were white ethnicity and distressed mood (CES-D >or= 16) (34% of the variance explained). The primary predictor of lower MC scores was distressed mood (R(2) = 0.45). Lower PC scores were associated with older age, living alone, FEV1 less than 70% of predicted, distressed mood, time since diagnosis, and more comorbid diseases (R(2) = 0.28). CONCLUSION These findings provide the first description of the QOL of long-term survivors of lung cancer. Risk factors for poorer QOL are strongly linked to distressed mood, which is a potential target for intervention.
Contemporary challenges in archival science and possible guidelines for universities to confront them

The aspect of archival science as a scientific discipline is quite young compared to other scientific disciplines. The field of the archival science education was not systematically regulated in Slovenia, since the study of archival science at the public university was not established. Knowledge of what is necessary in the elaboration of the device to emphasize, archivists usually acquire with longstanding work in archives and in direct contact with users. By analysing the current needs and issues “on the field” at records creation in this paper the author will compare those results to results of analysis of educational program of archival science and records management in Slovenia, as well as further orientations for improving it. The article attempts to determine how satisfactory is the approach of pedagogical process to fulfil the knowledge gap of archival records creators and archives.
A CLF-based nonlinear control technique for a grid-connected voltage source inverter with LCL filter used in renewable energy power conditioning systems

A novel control scheme based on the Control Lyapunov Function (CLF) is proposed in this paper for a grid-connected voltage source inverter with an LCL filter. The proposed control approach is able to significantly increase the bandwidth of the closed-loop control system and offer a very fast transient response compared to the conventional Proportional Resonant (PR) controllers. The proposed CLF-based controller guarantees the closed-loop stability and perfect disturbance rejection for the voltage source inverter with LCL-filter. The specific Lyapunov function proposed in this paper includes the integral of the errors in order to account for parameter uncertainties in the system model. The CLF-based controller is implemented on a 1kW voltage source inverter prototype to verify the performance of the proposed control scheme. The experimental results show a significant improvement in the performance of the converter with the proposed control scheme compared to the conventional PR controller.
Characterization of a Salmonella typhimurium aro vaccine strain expressing the P.69 antigen of Bordetella pertussis

The P.69 Bordetella pertussis protective antigen was expressed by use of the trc promoter from the chromosome of a Salmonella typhimurium aro vaccine strain, BRD509, by integrating the prn gene, encoding the 93-kDa precursor of this protein, into the aroC locus. P.69 was detected on the cell surface of the S. typhimurium strain (BRD640) by agglutination and immunoelectron microscopy. BALB/c mice immunized orally or intravenously with BRD640 showed a significant level of protection against an aerosol challenge with virulent B. pertussis, compared with control animals. No anti-P.69 antibodies in the serum or anti-P.69 antibody-secreting cells in the lungs were detected in BRD640-vaccinated animals, although cells isolated from spleens showed a P.69-dependent cell proliferative response. In contrast, low levels of anti-P.69 antibodies in the serum and anti-P.69 antibody-secreting cells in the lungs were detected in immunized mice following a B. pertussis challenge.
Ameloblastomas: a regional Latin-American multicentric study.

AIM To classify 163 ameloblastoma cases according to the new WHO Classification of Odontogenic Tumours (2005) and analyse their clinical and microscopic features. METHODS We studied the clinico-pathological features of 163 ameloblastoma cases from nine regional Latin-American institutions from Mexico and Guatemala. RESULTS Ameloblastomas comprised 22.7% of all odontogenic tumours. The mean age was 41.4 years for solid ameloblastoma (SA) and 26.3 years for unicystic ameloblastoma (UA) (P < 0.001) and both sexes were almost equally affected. The mandible was mainly affected for both UA and SA. The mean size was 6.2 cm for SA and 6.3 cm for UA cases. The recurrence rate was 21.7% for SA and 12.6% for UA. UA was twice as more frequent than the solid variant. CONCLUSIONS In this study we found that UA was frequently misdiagnosed as SA; however, there are enough clinical and microscopic features that allow for an accurate differentiation between both types of ameloblastoma that should be recognized for surgical and prognostic purposes. In this study, SA was not found in patients younger than 20 years, UA had a constant myxoid stroma while mature connective tissue was more frequently associated with the solid type.
IMPACTO DE LA INFRAESTRUCTURA DE SALUD PÚBLICA EN EL DESARROLLO SUSTENTABLE, DE LA ZONA METROPOLITANA DE TEHUANTEPEC EN OAXACA

La presente investigacion tiene como objetivo analizar el impacto de la infraestructura de salud publica en el desarrollo sustentable de la Zona Metropolitana de Tehuantepec (ZMT), Oaxaca. Actualmente, la salud de la poblacion en Mexico es precaria y esta disminuye la capacidad laboral y productiva de las personas, que afecta a todos los pobres, al ser los que realizan los trabajos de mayor esfuerzo fisico, por esta razon, una mala salud afecta al desarrollo fisico de los ninos, su escolarizacion, aprendizaje y desarrollo, por ello se enfatiza que la salud es una de las condiciones mas importantes de la vida humana y esencial para el bienestar y desarrollo. Asi mismo, el bajo nivel de institucionalizacion del sector salud, la deficiente cobertura de los servicios, los bajos indices en atencion y mala calificacion del personal, han hecho que el indicador de salud en Mexico se mantenga entre los paises peor situados. Durante los ultimos anos se ha incrementado la afiliacion de la poblacion sin seguridad social al sistema de proteccion de salud, sin embargo, la afiliacion no responde su derecho a la proteccion de salud dado que reside la desigualdad, discriminacion y falta de recurso material y humano. La salud no solo es importante para el bienestar de individuos, familias y comunidades, si no que constituye un poderoso instrumento para alcanzar el desarrollo social y economico, es decir, la salud de las poblaciones y de sus individuos se relaciona con su desarrollo. El analisis demuestra la carencia que existe en la construccion de la politica social y en especifico dentro del sector salud. El impacto de la infraestructura de salud publica en el desarrollo sustentable de la ZMT, se analizara mediante la construccion de variables cuantitativas a partir de datos en salud publica (IMSS, ISSSTE, PEMEX, SEMAR y SSa).
Addition of high-mannose sugars must precede disulfide bond formation for proper folding of Sendai virus glycoproteins

The role of glycosylation and of disulfide bonds in the formation of the native structure of the Sendai virus hemagglutinin-neuraminidase (HN) and fusion (F0) glycoproteins was studied. In contrast to the HN and F0 synthesized in vivo, the proteins made from pSP6 transcripts in reticulocyte lysates, whether glycosylated or not, were not recognized by monoclonal antibodies or polyclonal rabbit sera raised against the native proteins; they efficiently reacted only with rabbit antisera raised against the reduced sodium dodecyl sulfate-denatured proteins. These in vitro-made proteins, however, did not contain disulfide bonds. The proteins made in vivo in the presence of tunicamycin, which were also not recognized by the anti-native protein antibodies, did contain disulfide bonds, but they were mainly incorrect interchain disulfide bonds. Moreover, while F0 acquired proper disulfide bonds as soon as it was synthesized under normal conditions in vivo, the disulfides were formed in HN only after a lag of 10 to 30 min. This lag coincides with the delay observed in HN native structure formation. We therefore conclude that the maturation of the HN and F0 proteins depends on the formation of proper intramolecular disulfide bonds, which in turn depends on the previous addition of high-mannose sugars.
Strategies for the Treatment of Acute Renal Failure in Intensive Care Units: The Aspect of Dosing

Despite all the medical progress, the mortality rate in intensive care units for patients with acute renal failure (ARF) remains high, among specific patient populations, up to 88% [Letourneau I, Dorval M, Belanger R, Legare M, Fortier L, Leblanc M. Acute renal failure in bone marrow transplant patients admitted to the intensive care unit. Nephron Apr 2002; 90(4), 408–12. ]. Recent trial results indicate that patient survival may be improved by adequate renal replacement therapy. In particular, the dose of intermittent and continuous renal replacement therapies has proved to be a significant factor affecting patient survival. Daily intermittent hemodialysis, e.g., is superior to alternate‐day intermittent hemodialysis, and with continuous therapies, survival is related to the filtration rate. Further relevant factors include early initiation of renal replacement therapy, choice of biocompatible membranes and the application of bicarbonate‐buffered replacement solutions for defined patient groups. The advantages offered by continuous techniques could be demonstrated for individual patient groups; in meta‐analyses, advantages were shown for the total population of patients with ARF. Other than for patients with chronic renal failure (NKF—DOQI. Clinical practice guidelines for hemodialysis adequacy. Am J Kid Dis 1997; Vol. 30, 515–566.), there are no current clinical guidelines for a standard treatment of intensive care patients with ARF. Therefore, such a treatment standard still needs to be determined.
Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells.

AIM To investigate the apoptotic activities of casticin in hepatocellular carcinoma (HCC) cells and its molecular mechanisms. METHODS PLC/PRF/5 and Hep G2 cell lines were cultured in vitro and the inhibitory effect of casticin on the growth of cells was detected by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolim bromide (MTT) assay. The apoptotic cell death was examined using the cell apoptosis enzyme linked immunosorbent assay (ELISA) detection kit, flow cytometry (FCM) after propidium iodide (PI) staining and DNA agarose gel electrophoresis. The caspase activities were measured using ELISA. Reactive oxygen species (ROS) production was evaluated by FCM after dichlorodihydrofluorescein diacetate (DCFH-DA) probe labeling. Intracellular glutathione (GSH) content was measured using a glutathione assay kit. The expression of death receptor (DR)4 and DR5 proteins was analyzed by Western blotting and FCM. RESULTS Casticin significantly inhibited the growth of human HCC (PLC/PRF/5 and Hep G2) cells in a dose-dependent manner (P < 0.05). Casticin increased the percentage of the sub-G1 population in HCC cells in a concentration-dependent manner. The potency of casticin to PLC/PRF/5 cells was higher than that of 5-flurouracil (26.8% ± 4.8% vs 17.4% ± 5.1%) at 10 μmol/L for 24 h. Casticin increased the levels of Histone/DNA fragmentation and the levels of active caspase-3, -8 and -9 in a concentration-dependent manner (P < 0.05). Treatment with 30 μmol/L casticin for 24 h resulted in the formation of a DNA ladder. Casticin reduced the GSH content (P < 0.05), but did not affect the level of intracellular ROS in PLC/PRF/5 and Hep G2 cells. The thiol antioxidants, acetylcysteine (NAC) and GSH restored GSH content and attenuated casticin-induced apoptosis. In contrast, the nonthiol antioxidants, butylated hydroxyanisole and mannitol failed to do so. In the HCC cells treated with casticin for 24 h, DR5 protein level was increased. The expression of DR5 protein induced by casticin was inhibited by NAC. Pretreatment with DR5/Fc chimera protein, a blocking antibody, effectively attenuated the induction of apoptosis by casticin. CONCLUSION Casticin-induced apoptosis of HCC cells is involved in GSH depletion and DR5 upregulation.
Imatinib and Panax Ginseng: A Potential Interaction Resulting in Liver Toxicity

OBJECTIVE: To report a case of imatinib-induced hepatotoxicity after concurrent ginseng ingestion in a patient with chronic myelogenous leukemia (CML). CASE SUMMARY: A 26-year-old man with CML who had taken imatinib 400 mg daily for 7 years with no complications presented with right upper quadrant pain. Laboratory test results included alanine aminotransferase 1069 U/L, aspartate aminotransferase 481 U/L, alkaline phosphatase 124 IU/L, total bilirubin 1.4 mg/dL, albumin 4.0 g/dL, and international normalized ratio 1.08. Liver biopsy showed acute lobular hepatitis favoring a drug-induced etiology, and a diagnosis of imatinib-induced hepatotoxicity was made. The patient's only lifestyle modification prior to the diagnosis of hepatotoxicity was daily ingestion of Panax ginseng via energy drinks for the past 3 months. Both imatinib and ginseng were discontinued, and the patient was treated with a short course of corticosteroids. Imatinib was later restarted at the same dose with no recurrent elevations in his liver enzyme levels. DISCUSSION: Imatinib-associated hepatotoxicity usually presents within 1-2 years of therapy initiation, with the median time to hepatotoxicity being 100 days. Ginseng is an herb that is not known to be hepatotoxic. In vivo, ginseng is known to inhibit CYP3A4, the primary enzyme involved in the metabolism of imatinib. We propose that our patient's late-onset imatinib-associated hepatotoxicity was due to an interaction between ginseng and imatinib through CYP3A4. Based on the Naranjo probability scale, it is probable that imatinib caused this patient's hepatotoxicity, and the Horn drug interaction probability scale also indicates a probable interaction between imatinib and ginseng. CONCLUSIONS: This case emphasizes the importance of continuous monitoring of liver function tests even after several years of imatinib therapy and the importance of advising patients to avoid ginseng and any other over-the-counter herbal supplements that may interact with imatinib.
Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice

Anaplastic thyroid carcinoma (ATC) remains one of the most lethal human cancers. We hypothesized that sorafenib, a multikinase inhibitor of the BRaf, vascular endothelial growth factor receptor-2, and platelet-derived growth factor receptor-β kinase, would decrease tumor growth and angiogenesis in an orthotopic model of ATC. The in vitro antiproliferative and proapoptotic effects of sorafenib on ATC cell lines were examined. To study the in vivo effects of sorafenib on orthotopic ATC tumors in nude mice, sorafenib was given p.o. at 40 or 80 mg/kg daily. Intratumoral effects were studied using immunohistochemical analysis. The effect of sorafenib on survival of the mice was also studied. Sorafenib inhibited the in vitro proliferation of ATC cell lines. Sorafenib also significantly inhibited tumor angiogenesis via the induction of endothelial apoptosis in an orthotopic model of thyroid cancer. As result, the growth of orthotopic ATC xenografts was reduced and the survival of the test animals was improved. Sorafenib exerts significant antitumor activity in an orthotopic xenograft model of ATC via a potent antiangiogenic effect. The antiangiogenic effects of sorafenib suggest that its use in clinical setting may not depend on the BRAF mutational status of thyroid tumors. Given the lack of curative options for patients with ATC, sorafenib warrants further study as a therapeutic agent against ATC. [Mol Cancer Ther 2007;6(6):1785–92]