Miracle-dz/UniFAR-FTUs huggingface dataset:
Extracellular matrix metalloproteinase inducer expression in histological grades of oral squamous cell carcinoma – An immunohistochemical study

Background: Oral squamous cell carcinoma (OSCC) is the most common type of head-and-neck cancer. It is a complex and relentless malignancy prone to local invasion and dissemination. An insight into the molecular alterations associated with metastasis will provide critical insights into the fundamental mechanisms underlying its progression and further contribute to improvements in the clinical management of H and N cancer patients. Hence, identifying specific biomarkers would pave the way for early detection and prognosis of OSCC. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a membrane-bound glycoprotein found on the surface of tumor cells. It plays a central role in the promotion of tumor invasion, progression and metastasis as it upregulates matrix metalloproteinases secreted from adjacent fibroblasts. There is a paucity of studies on the expression of EMMPRIN in OSCC. Objectives: The aim is to assess the immunohistochemical expression of EMMPRIN in OSCC and to compare it with the clinicopathological parameters and histological grades of OSCC. Materials and Methods: Thirty histopathologically diagnosed cases of OSCC were included in the study. The slides were immunohistochemically analyzed for EMMPRIN expression and correlated with the clinicopathological parameters and histological grades of OSCC. Results: EMMPRIN expression was noted in all 30 cases of OSCC. Strong EMMPRIN expression was noted in the advanced clinical stages of OSCC. Higher histological grades of OSCC exhibited strong EMMPRIN expression. Conclusion: EMMPRIN overexpression indicates that this protein could be used as an important biological prognostic marker to identify high-risk OSCC patients.
Clear cell odontogenic carcinoma in maxilla: A rare case report

A rare and aggressive form of tumor with a female predilection and more seen with mandible is the clear cell odontogenic carcinoma (CCOC). The World Health Organization categorized it as a malignant neoplasm in 2005. This type of tumor is characterized by local recurrences as well as distant metastasis apart from being highly aggressive in nature. Due to the presence of clear cells, it is a diagnostic challenge to the pathologist. Only about 84 cases of maxillary variant have been reported in the literature. Here, we present a case report of a 31-year-old male with CCOC in the maxilla from the pathological and diagnostic point of view.
Hypergraph based Partitioning on a Distributed RDF System

Due to the ﬂexibility and scalability of RDF (Resource Description Framework) data model, more and more communities have released their data in RDF format. Growth of RDF data throws a challenge for data management and query processing in optimized time. Current distributed RDF systems involve large of inter-node communication. This paper will focus on hypergraph based spanning tree partitioning and distributed processing system in order to handle large-scale RDF data eﬃciently. Algorithm for transformation of RDF graph into hypergraph is proposed: all the subjects and objects connected with a particular predicate in the RDF graph resides under a particular hyper edge. Chunks are generated on the help of the hypergraph spanning trees and distributed into several nodes, which can decrease the SPARQL query response time. The system performance is evaluated using the LUBM benchmark.
Is there a place for measuring serum calcitonin prior to thyroidectomy in patients with a non-diagnostic thyroid nodule biopsy?

ABSTRACT Objective: To verify the cytopathological Bethesda System classification of thyroid nodule fine-needle aspiration biopsy (FNAB) in MTC patients and to assess the role of preoperative serum calcitonin (CT) levels in the investigation of this neoplasm in medullary thyroid cancer (MTC) patients under observation at the Uopeccan (União Oeste Paranaense de Estudos e Combate ao Câncer). Materials and methods: This is a cross-sectional review of medical records of patients monitored at the thyroid cancer outpatient clinic of Uopeccan. Clinical and demographic data, laboratory tests, ultrasound images, and cytopathological findings of MTC patients were evaluated. Results and discussion: Among the 360 patients with thyroid cancer monitored in the outpatient clinic, 5.2% (n: 19/360) had MTC. The hereditary form was more prevalent (63.2%), and there was no sex preference. The most common ultrasound findings were hypoechogenicity, solid appearance and microcalcifications. The FNAB diagnoses showed a sensitivity of 47.1%, and the most common cytopathological report was Bethesda category III. Serum CT levels showed good sensitivity (84.6%) for the diagnosis of MTC, and sensitivity levels were directly associated with the size of the nodule and distant metastases. Conclusion: Bethesda category III was more prevalent in this group of MTC patients. Serum CT levels were more sensitive than cytopathology for diagnosis of this neoplasm and were able to identify all patients who could not be diagnosed by FNAB.
A Basic Review of Pain Pathways and Analgesia Pain and the Brain

Pain is not only difficult to treat but difficult to understand because it involves many complex processes that lead first to its recognition and then to an emotional response and reaction. As anesthesia providers, our interest in pain continues to grow because most of us will, at some point, be challenged by significant perioperative pain, and 100% of these patients will require treatment. Furthermore, concerns about the overuse of opioids for acute and chronic pain militate for a reduction in their use, and so anesthesiologists strive to find effective alternatives. To our opioid regimens, we are adding nonsteroidal anti-inflammatory drugs (NSAIDs), antidepressants, corticosteroids, alpha-2 agonists, ketamine, local anesthetics, magnesium, gabapentinoids, and acetaminophen. But do we really know how the brain is made aware of a painful stimulus, or how the many pain medications work on the nervous system? First, we need to understand that pain and nociception are two different things. Pain is the unpleasant experience caused by potential or actual tissue damage, and nociception is the transmission of a noxious stimulus to the brain and all the processes in between. The goal of this article is to methodically but simply walk through the pain pathway as it is currently understood, and show where therapies, both pharmacologic and physical, can intervene.
New Potentiometric Screen-printed Sensors for Determination of Trimebutine Drug in Tablets, Serum and Urine Samples

A new sensit4e and select4e modified screen printed electrodes (MSPEs) and carbon paste electrodes (MCPEs) were studied in order to determine trimbutine maleate (TM) in pure, tablets, urine, and serum samples. These sensors were embodied with multiwalled carbon nanotubes (MWCNTs) since it improved the quality of the sensors in presence of potassium tetrakis (p-chlorophenyl) borate (KTpClPB) ionophore. A good Nernstian response for the constructed sensors, at optimum paste composition, was exhibited for determination of TM in concentration range of 1.5 × 10-7 - 1.0 × 10-2 and 1.0 × 10-7- 1.0 × 10-2 mol L-1 at 25 °C with detection limit of 1.5 × 10-7 and 1.0 × 10-7 mol L-1 for MCPE and MSPE, respect4ely. It seemed that the potential of the electrodes was independent on pH in the range of 2.0-8.0, 2.0-8.5, 2.0-8.5, and 2.0-9.0 g4ing slope as 56.77 ± 1.11, 57.82 ± 0.54, 57.95 ± 0.37, and 58.99 ± 0.28 mV decade-1 for electrodes 1, 2, 3 and 4, respect4ely. MCPEs and MSPEs gave response time about 8 and 6 s with long lifetime (more than 3 and 5 months), respect4ely. A high select4ity of sensors was observed for TM regarding to a large number of interfering species. The constructed sensors were successfully applied for determination of TM in pure form, its pharmaceutical preparations and biological fluids using standard addition, calibration, and potentiometric titration methods with high precision and accuracy. The results showed a good agreement between the proposed method and the HPLC official method.
Studies of Mediterranean Oregano Population IV—Chemical Composition of Essential Oils of Hybrids Origanum x majoricum Cambassedes from France, Origanum x intercedens Rechinger and Origanum x minoanum Davis from Turkey and Crete

Abstract Essential oils isolated by water distillation were analyzed by GC and GC/MS. In Origanum x majoricum, 74 constituents were identified. The trans-sabinene hydrate and carvacrol were the most prominent compounds, followed by sabinene, γ-terpinene and terpinen-4-ol. In O. x intercedens and O. x minoanum, 67 and 85 compounds were identified, respectively, with carvacrol predominating (75–80%) in both hybrids.
LIQUID BIOPSY OF INTRACRANIAL NEOPLASMS: REACHING THE UNREACHABLE

Glioma tends to envelop more than 80% of primary malignant tumors amongst all the intracranial neoplasms claiming poor prognosis and lower survival rate. Tumor tissue biopsy is general mode of diagnosis for the disease. However, it encounters certain limitations mainly delayed diagnosis, inadequate sampling and misdiagnosis. Besides, information attained from a single biopsy provides a spatially and temporally limited snap-shot of a tumor which in turn lacks or fails to reflect its heterogeneity. This issue can be circumvented with the recent advent of “Liquid Biopsy “that impart better understanding of the tumor dynamics and augment minimal invasiveness for disease diagnosis together with its serial monitoring. Likely with other malignancy, Glioma tissues also release their molecular information in circulation mainly blood and cerebrospinal fluid. This review majorly summarizes the blood and cerebrospinal fluid based biomarkers predominantly circulating tumor cells, cell free DNA and exosomes that can guide patient management. It covers varied areas from techniques to isolate these markers to their characterization and their further application in field of early diagnosis and treatment.
Hybridizing GWO with PSOGSA for Solving Global Optimization and ELD Problem

A new hybrid population-based algorithm PSOGSA combining GWO is proposed in this paper (GWO-PSOGSA). This paper achieves improved results using GWO and PSOGSA by synthesizing both algorithms’ strength. Few standardized benchmark test functions are used for comparison of hybrid algorithm with the standard GWO. Hybrid GWO is implemented on ELD problem using 3 unit and 6 unit systems. Results obtained proved that hybrid algorithm achieves better capability with faster convergence when compared with the standard GWO, Cuckoo search algorithm and Lambda iteration method
Separation of local bulk and surface recombination in crystalline silicon from luminescence reabsorption

Spontaneous photoemission of crystalline silicon provides information on excess charge carrier density and thereby on electronic properties such as charge carrier recombination lifetime and series resistance. This paper is dedicated to separating bulk recombination from surface recombination in silicon solar cells and wafers by exploiting reabsorption of spontaneously emitted photons. The approach is based on a comparison between luminescence images acquired with different optical short pass filters and a comprehensive mathematical model. An algorithm to separate both front and back surface recombination velocities and minority carrier diffusion length from photoluminescence (PL) images on silicon wafers is introduced. This algorithm can likewise be used to simultaneously determine back surface recombination velocity and minority carrier diffusion length in the base of a standard crystalline silicon solar cell from electroluminescence (EL) images. The proposed method is successfully tested experimentally. Copyright © 2009 John Wiley & Sons, Ltd.
Intensional harmony as isomorphism

In the present paper we discuss a recent suggestion of Schroeder-Heister concerning the possibility of deﬁning an intensional notion of harmony using isomorphism in second-order propositional logic. The latter is not an absolute notion, but its deﬁnition is relative to the choice of criteria for identity of proofs. In the paper, it is argued that in order to attain a satisfactory account of harmony, one has to consider a notion of identity stronger than the usual one (based on 𝛽 - and 𝜂 -conversions) that we have investigated in recent work.
SOME FACTORS AFFECTING NICOTIANA GLAUCA GRAHAM GROWTH AND ACTIVE INGREDIENTS

This study was carried out at El-Sheikh Zewaied Research Station, Desert Research Centre at North Sinai Governorate during the two seasons of 2003/ 2004 and 2004/ 2005 to study the effect of different levels of compost (0, 4, 8 and 12 m/ fad.), saline water irrigation (600, 1500 and 3000 ppm) and their interaction on growth, active ingredients and chemical constituents of tree tobacco (Nicotiana glauca) plants. Results indicated that the maximum yield of active ingredients (total alkaloids, anabasine and rutin) and the highest values of growth characters (plant height, number of branches, dry weight of plant and dry weight of leaves/ plant) and plant minerals content (N, P, K, Zn, Mn and Fe) could be obtained when plants were irrigated with saline water at 1500 ppm with the addition of 12 m/fad compost during soil preparation.
IDENTIFICATION OF USEFUL ALLELE OF ZmRCCR FOR CHLOROPHYLL COMPOUNDS DURING MATURATION IN MAIZE

Candidate association mapping for red chlorophyll catabolite reductase gene (ZmRCCR) were analyzed for chlorophyll content in 141 maize inbred lines. Finally, 18 polymorphic sites were identified, which were significantly associated with the chlorophyll-related traits. The InDel S-53 from 5'UTR (5' untranslated region) decided 9.81% of phenotypic variation for chlorophyll a at T5 in Yangling, and also explained 10.05% phenotypic variation for chlorophyll b at T5 in Yulin. Excitingly, another In Del S278 in the exon 1 was associated with six traits, and the phenotypic interpretation rate range from 10.67 to 24.99%. These results indicated that ZmRCCR plays an important role in chlorophyll compounds content during maturation with more than one independent locus. Furthermore, these findings improve the understanding of the genetic basis of dynamic chlorophyll metabolism in late mature maize and provide information for the development of functional markers based on ZmRCCR. Introduction Chlorophyll is one of the most important photosynthetic pigments in the biosphere, which is mainly chlorophyll a (Chl a) and chlorophyll b (Chl b). Chlorophylls form light system and light system reaction takes place by absorbing light energy and converting photon energy into chemical energy in the form of excitation (Mathis and Burkey 1989, Agostiano et al. 1990), which plays a central role in photosynthesis (Tanaka et al. 1991). The chlorophyll content is an important physiological index to measure leaf senescence and is an important factor restricting the further improvement of maize yield (Liu 1983). The study of chlorophyll metabolism has been developing very fast because of its important role. Until 2003, chlorophyll metabolisms had been descripted clearly in model plant Arabidopsis by forward and reverse genetics. And the schematic of chlorophyll metabolism has been expounded plainly including chlorophyll synthesis, chlorophyll cycle and chlorophyll degradation (Hortensteiner and Krautler 2011). Chlorophyll breakdown begins with the chlorophyllase which catalyzed the formation of chlorophyllide, and then a metal chelate to remove magnesium ions to form pheophorbide a, the macrocyclic ring of pheide a is then opened by pheophorbide an oxygenase (PAO), chlorophyllase (RCC). The RCC is further catabolized into primary fluorescence fluorescent catabolite (pFCC) by RCCR and finally transported to vacuole after several modifications and is transformed into Non-fluorescent chlorophyll catabolite (NCCs) (Hortensteiner and Krautler 2011). Red chlorophyll catabolite reductase (RCCR) relies on the reduced ferredoxin (fd) to provide electrons for the reduction of double strands between C20/C1 in RCC, converting RCC to pFCC (Pruzinska et al. 2007). At present, RCCR gene has been cloned successfully in Arabidopsis and *Author for correspondence: <shutuxu@nwafu.edu. cn>. Department of Plant Breeding, Yezin Agricultural University, Nay Pyi Taw, Myanmar 15013.
BRAIN TUMOR CLASSIFICATION USING CONVOLUTIONAL NEURAL NETWORK WITH PARALLEL PROCESSING

The recent decade has witnessed the rise of machine learning implementation in various domains. The processing and classifications of medical images such as the MRI images of the brain tumors is one of the disciplines where various approaches and methodologies using machine learning algorithms have been proposed. The paper compares the serial implementation with the parallel implementation of the machine learning model to classify brain tumor MRI images. The implemented model for serial processing provides an accuracy 90% and f1 score of 0.93. Whereas the implemented model for parallel processing provides 94% and f1 score of 0.95. As the mortality rate of the brain tumor is extremely high. Hence, discovering the tumor cells in the initial phases and at a faster pace is one of the best ways to eliminate cancer. Using machine learning algorithms with the combination of image processing methods is a powerful tool that not only improves accuracy, and precision but also speeds up the process to classify whether the tumor is malignant or benign
Alat Negara yang berperan dalam memelihara keamanan dan ketertiban masyarakat, menegakkan hukum, memberikan pengayoman dan pelayanan

This research aims at: I ) Explaining the direct injluence of organizational culture and leadership to learning organization; 2) Analyzing and clarijjting the straight influnce of organizational culture and leadershi$ to organizational performance; 3) Investigating and defining the undeviating influence of learning to organizational performance; 4) Stu4ing andjusti$ing the indirect influence of organizational culture and ieadership to organizational performance through learning organization. The sample of this were 167 officiers in Directorate IV/Drug Crime and ~ r ~ a n i z e d ~ r i m e BARES&MPOLRI. The method of data anahisis applied was path analysis. The results of the reasearch show: 1) Organizational culture takes a srgnificmt role in learning organization, 2) Leadership obvious injluence to learning organization; 3) Organization cultural take no role in organizational performance; 4) Leadership does not have any influnce to organizational performance; 5) Learning organization takes an important part in organizational performatlce; 6) Learning organization takes a role as medium of the injlunce of organization culture and org~nizational performance; 7) Learning organization fitnctions as the medium for leadership and organizational performance.
Real-Time Data Processing With Lambda Architecture

Data has evolved immensely in recent years, in type, volume and velocity. There are several frameworks to handle the big data applications. The project focuses on the Lambda Architecture proposed by Marz and its application to obtain real-time data processing. The architecture is a solution that unites the benefits of the batch and stream processing techniques. Data can be historically processed with high precision and involved algorithms without loss of short-term information, alerts and insights. Lambda Architecture has an ability to serve a wide range of use cases and workloads that withstands hardware and human mistakes. The layered architecture enhances loose coupling and flexibility in the system. This a huge benefit that allows understanding the trade-offs and application of various tools and technologies across the layers. There has been an advancement in the approach of building the LA due to improvements in the underlying tools. The project demonstrates a simplified architecture for the LA that is maintainable. Index terms – Lambda Architecture (LA), Batch Processing, Stream Processing, Real-time Data Processing
Effects of Intracranial Interventional Embolization and Intracranial Clipping on Neurologic Function, Immune Status and Sleep Quality of Patients with High Grade Aneurysmal Subarachnoid Hemorrhage*

摘要目的:比较颅内介入栓塞术与颅内夹闭术对高分级动脉瘤性蛛网膜下腔出血(aSAH)患者神经功能、免疫状态及睡眠质量的 影响。 方法:回顾性分析我院自 2015年 1月到 2019年 8月收治的高分级 aSAH患者 80例的临床资料,根据手术方式的不同将患 者分为 A组(n=38,颅内夹闭术)和 B组(n=42,颅内介入栓塞术),比较两组患者疗效、神经功能、免疫状态、睡眠质量及并发症发 生情况。 结果:B组的预后良好率为 73.81%(31/42),高于 A组的 60.53%(23/38)(P<0.05)。 两组患者术后 3个月美国国立卫生研 究所卒中量表(NIHSS)、匹兹堡睡眠质量指数量表(PSQI)评分均降低,且 B组低于 A组(P<0.05)。 两组患者术后 1d、术后 5d免 疫球蛋白(Ig)G、IgA及 IgM均呈先下降后升高趋势,B组术后 1d、术后 5d IgG、IgA及 IgM均高于 A组(P<0.05)。 B组的术后并 发症发生率为 11.90%(5/42),低于 A组的 31.58%(12/38)(P<0.05)。 结论:颅内介入栓塞术应用于高分级 aSAH患者的疗效优于 颅内夹闭术,并且可以改善患者的神经功能、睡眠质量,减少并发症发生风险,减轻免疫抑制。 关键词:颅内介入栓塞术;颅内夹闭术;动脉瘤性蛛网膜下腔出血 中图分类号:R743.34 文献标识码:A 文章编号:1673-6273(2020)18-3524-04
Phosphorus Flows in the Asian Region

In just about every aspect of life, dependency can be equated with vulnerability, and in the case of phosphorus, this vulnerability potentially puts whole nations at significant risk. Phosphorus is vital in the semi-conductor industry, automobile industry, fertilizer industry and all aspects of agriculture. With one third of the world’s population housed in Asia and the numbers steadily rising, the demand for phosphorus is growing rapidly. The cultural shifts and changes in consumption that come with economic improvements and urbanization throughout Asia are pushing the demand for phosphorus to grow at an ever faster rate. Confidence that the rising populations of Asia will have sufficient food in the future can only come from the knowledge that the necessary phosphorus will be readily available. In order to ensure this and to ensure industry will have the phosphorus it requires, it is essential to understand the flow of phosphorus in the region and the nature and risks associated with phosphorus dependence.
UNITE MIXTE DE RECHERCHE EN ECONOMIE PUBLIQUE JOINT RESEARCH UNIT IN PUBLIC ECONOMIC

Agriculture contributes significantly to the emissions of greenhouse gases in the EU. By using a farm-type, linear-programming based model of the European agricultural supply, we first assess the initial levels of methane and nitrous oxide emissions at the regional level in the EU. For a range of CO2 prices, we assess the potential abatement that can be achieved through an IPCC-based emission tax in EU agriculture, as well as the resulting optimal mix of emission sources in the total abatement. Further, we show that the spatial variability of the abatement actually achieved at a given carbon price is large, indicating that abatement cost heterogeneity is a fundamental feature in the design of a mitigation policy. We assess the efficiency loss associated with uniform standards relative to a an emission tax.
Robust Incentive Contract with Disagreement about Performance Evaluation and Compensation

This paper examines a principal-agent model with moral hazard, where the agent can disagree with the principal about how he should be evaluated and paid, and creates organizational frictions when the actual outcome falls short of what he thinks he deserves. The main result shows that seemingly rigid policies, such as long-term performance appraisals, compressed compensation schemes and seniority-based promotions, are robust tools for providing incentives and mitigating disagreements, especially when the exact cause of the disagreement is not commonly known between contracting parties. ∗Department of Economics, Washington University in St. Louis. anqili@wustl.edu. Acknowledgment to be added.
Fabrication and determination of performance parameters of a pyrene-based organic thin-film transistor

Organic semiconductors broaden the applications of thin-film transistors, as a flexible substrate can be used. Hence, many organic semiconductors are being studied in the search for high-mobility organic semiconductors. Nevertheless, pyrene-based organic semiconductors have not been studied exhaustively. In this project we aim to reproduce and determine the key performance parameters of a pyrene-based OTFT presented in [1].