Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of primary pulmonary alveolar proteinosis: A multicentric experience

Background: Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by alveolar accumulation of surfactant material with reduced lung function and resulting hypoxemia. It is characterized by a variable clinical course, and whole lung lavage (WLL) is the standard treatment. Herein, we report our multicentric experience of management of primary PAP. Materials and Methods: This retrospective study included patients with PAP managed at various armed forces respiratory centers from 2009 to 2019. The diagnosis of primary PAP was based on histopathologic confirmation on transbronchial lung biopsy or open lung biopsy and absence of causes of secondary PAP. We analyzed the response to WLL in these patients as well as the safety of the procedure. Results: During the above-specified period, ten patients with a diagnosis of PAP were admitted to various armed forces respiratory centers. The median age of the patients was 34.5 years (range 23–59); there were nine males (90%). The mean duration (± standard deviation) of symptoms was 10.8 (±2.70) months. For management, WLL was done for eight patients with a median volume of 23.5 L (range 18–45) per patient. All the patients showed significant symptomatic response as well as improvement in physiological parameters with no major complications. The median follow-up of all patients was 18 (range 5–44) months. Conclusions: WLL is a safe, effective therapy in an experienced setting in patients with PAP and provides long-lasting benefits.
Three dimensional (3D) imaging techniques in orthodontics-An update

3D imaging is a technique which develops or creates the impression of depth within an image by deploying 2D data into 3-dimensional format. To aid in quality regulating processes for industrial purposes, 3D imaging has become an extremely valuable factor. Owing to their various drawbacks, a wide range of investigative methods formulated for demonstration of facial structures and the dentition were dilapidated. Currently in medicine, the most prevalent method is perhaps 3D imaging technique renders thorough and problem specific information regarding hard and the soft tissues, such as Computerized Tomography (CT), Cone Beam Computerized Tomography (CBCT), Micro Computerized Tomography (MCT), 3D laser scanning, structured light technique, stereophotogrammetry or 3D surface imaging systems (3dMD), 3D facial morphometry (3DFM), Tuned Aperture Computed Tomography (TACT), and Magnetic Resonance Imaging (MRI). 3D imaging techniques in orthodontics plays an important role by facilitating more elaborated diagnostic information on the precise cases like patients having craniofacial anomalies. Hence, the aim of this study was to review advances in 3D imaging with in the field of orthodontics.
Details of a confrontation between two wild wolves

A confrontation was photographed and videotaped at close range between a wild alpha male wolf (Canis lupus) of known history and an alien adult on Ellesmere Island, Northwest Territories, Canada. For 100–110 seconds the two stood near each other, maneuvered around, and snapped at each other until the alien fled. The alpha and his mate, who suddenly joined the encounter, chased the other wolf for 1.2 km and gave up without inflicting wounds. Discussed are possible reasons why this wolf was not killed, while other alien wolves have been.
Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge

Although ofloxacin-ornidazole fixed-dose combination (FDC) is a rampantly used antibiotic combination for mixed-infection diarrhea in India, the adverse drug reaction (ADR) associated with these FDCs remains underreported. Herein, the authors present a case report of a definitive ofloxacin-ornidazole FDC-induced pancreatitis. The nonalcoholic adult male patient showed a sharp piercing epigastric pain flowing to the back, gradually rising in severity, which started after taking ofloxacin-ornidazole FDC tablet over the counter. Serum lipase concentration measured in the emergency room was 635 units per liter (normal range- 13–60 units/L) and serum amylase was 377 units/L (normal range- 30–110 units/L). Ultrasonography and an axial computed tomography of the abdomen confirmed the diagnosis of acute pancreatitis. Ofloxacin-ornidazole FDC tablet was stopped immediately. Past treatment records confirmed accidental rechallenge. In conclusion, this is a first case report of ofloxacin-ornidazole FDC-induced pancreatitis.
Expression and Activation of Signal Regulatory Protein α on Astrocytomas

High-grade astrocytomas and glioblastomas are usually unresectable because they extensively invade surrounding brain tissue. Here, we report the expression and function of a receptor on many astrocytomas that may alter both the proliferative and invasive potential of these tumors. Signal regulatory protein (SIRP) α1 is an immunoglobulin superfamily transmembrane glycoprotein that is normally expressed in subsets of myeloid and neuronal cells. Transfection of many cell types with SIRPα1, including glioblastomas, has been shown to inhibit their proliferation in response to a range of growth factors. Furthermore, the expression of a murine SIRPα1 mutant has been shown to enhance cell adhesion and initial cell spreading but to inhibit cell extension and movement. The extracellular portion of SIRPα1 binds CD47 (integrin-associated protein), although this interaction is not required for integrin-mediated activation of SIRPα1. On phosphorylation, SIRPα1 recruits the tyrosine phosphatases SHP-1 and SHP-2, which are important in its functions. Although SHP-1 is uniquely expressed on hematopoietic cells, SHP-2 is ubiquitously expressed, so that SIRPα1 has the potential to function in many cell types, including astrocytomas. Because SIRPα1 regulates cell functions that may contribute to the malignancy of these tumors, we examined the expression of SIRPs in astrocytoma cell lines by flow cytometry using a monoclonal antibody against all SIRPs. Screening of nine cell lines revealed clear cell surface expression of SIRPs on five cell lines, whereas Northern blotting for SIRPα transcripts showed mRNA present in eight of nine cell lines. All nine cell lines expressed the ligand for SIRPα1, CD47. To further examine the expression and function of SIRPs, we studied the SF126 and U373MG astrocytoma cell lines, both of which express SIRPs, in greater detail. SIRP transcripts in these cells are identical in sequence to SIRPα1. The expressed deglycosylated protein is the same size as SIRPα1, but in the astrocytoma cells, it is underglycosylated compared with SIRPα1 produced in transfected Chinese hamster ovary cells. It is nonetheless still capable of binding soluble CD47. Moreover, SIRPα1 in each of the two cell lines recruited SHP-2 on phosphorylation, and SIRPα1 phosphorylation in cultured cells is CD47 dependent. Finally, examination of frozen sections from 10 primary brain tumor biopsies by immunohistochemistry revealed expression of SIRPs on seven of the specimens, some of which expressed high levels of SIRPs. Most of the tumors also expressed CD47. This is the first demonstration that astrocytomas can express SIRPα. Given the known role of SIRPα in regulating cell adhesion and responses to mitogenic growth factors, the expression of SIRPα1 on astrocytomas may be of considerable importance in brain tumor biology, and it offers the potential of a new avenue for therapeutic intervention.
Child abuse and neglect in a rapidly developing country: Parents’ perspectives

Purpose: To identify parental awareness and knowledge regarding child abuse and neglect in the State of Qatar. Methods: A cross-sectional study using a questionnaire was conducted at Hamad Medical Corporation, the only tertiary pediatric hospital in the State of Qatar at the time of the study. Parents of children of all ages were offered a questionnaire that included demographic details, parental knowledge, and awareness of child abuse and neglect. Results: 300 questionnaires were completed (response rate = 95%). More than 70% of parents were older than 30 years of age, 60% of them were females, and 66% were college graduates. The majority of the participants stated their familiarity about child abuse, and 6% witnessed morbidity or mortality due to child abuse in the society. Despite the identified laws, only 50% of the parents were aware of laws restricting child abuse. In regards to children with special needs, only 16% of the participants agreed that disabled children are at a higher risk of abuse compared to healthy children, while 33% were neutral and 52% disagreed. In addition, one-fifth of the respondents stated that hitting is discipline, while 63% disagreed. Almost one-third of the respondents agreed that hitting hands and buttock or hitting with soft objects is acceptable form of discipline. Unexpectedly, one-quarter of participants stated that it is okay to hit a child as long as no damage incurs. As for verbal abuse, around one-third of parents stated that yelling is not a form of child abuse, and that yelling does not affect growth and development. Comparing both corporal and verbal abuse, approximately 70% of parents stated that yelling is less harmful than hitting. In terms of child neglect, around half of the respondents agreed with the statement “Leaving a child (<5 years) unattended at home is a form of neglect,” while 42% were neutral. Finally, approximately 50% of the participants believed that it is okay to depend on nannies in assisting their children in eating and using the bathroom. Conclusion: Parents residing in the State of Qatar believe that they have a good knowledge regarding child abuse and neglect. However, this study shows many deficiencies in parental knowledge of child abuse and neglect. Parents' attitudes and perceptions are considered indispensable targets for community health intervention.
Brief Bubble and Intermittent Surface Oxygenation Is a Simple and Effective Alternative for Membrane Oxygenation During Hypothermic Machine Perfusion in Kidneys

Background. The aim of this feasibility study was to determine an alternative oxygenation technique (easy, cheap, and compatible with air transport) for membrane oxygenation during hypothermic machine perfusion (HMP) to improve early graft function in a porcine ischemia-reperfusion autotransplant model. Methods. The left kidney of a ±40- kg pig was exposed to 30 minutes of warm ischemia before 22 hours of preservation and autotransplantation. In the experimental group, oxygenation of the perfusate during HMP was obtained by direct bubble and 30-minute surface oxygenation at start and 1-hour end ischemic (n = 4) and outcome measures compared with historical HMP without active oxygenation (n = 6), 22-hour continuous oxygenated HMP (HMPO2) (n = 8), and 2-hour HMPO2 + 20-hour HMP (n = 6) using membrane oxygenation in both historical oxygenated control groups. Results. Brief bubble and 30-minute surface oxygenation of the perfusate effectively maintained supraphysiological Po2 levels during the first 2 hours of HMP with improved flow dynamics. Although the metabolic profile of the perfusate (ie, flavin mononucleotide) and tissue (ie, glutamate, ATP) after brief O2 uploading at the start of HMP seemed to be slightly better with the use of a membrane oxygenator compared with bubble and interrupted surface oxygenation, both techniques yielded similar, superior early graft function when compared with HMP without active oxygenation. Conclusions. The data presented in this feasibility study support the conclusion that brief bubble and intermittent surface oxygenation could be an alternative oxygenation technique during HMP to achieve an improved kidney graft function compared with HMP without active oxygenation and similar functional outcome when compared with membrane HMPO2.
Digestion and rumen metabolism of red clover and perennial ryegrass/white clover forages by red deer

SUMMARY Red clover (RC) and perennial ryegrass (PRG)-based forages were cut fresh during late spring/early summer and fed at similar levels of dry matter (DM) intake to rumen fistulated castrated red deer kept indoors in metabolism pens. RC contained higher concentrations of total N and non-protein cell contents than PRG and lower concentrations of fibre. Rumen pool size and fractional outflow rates of liquid (13·3 ν. 15·1%/h) and of paniculate matter (2·5 ν. 3·9%/h) were lower for deer fed RC than PRG. Apparent digestibility of energy and fibre, rumen fibre fractional degradation rate and rumen fractional disappearance rate of non-protein cell contents were all higher for RC than for PRG deer. Nitrogen retention was similar for deer fed both forages. However, the concentration, pool size and outflow of ammonia from the rumen, together with urinary N excretion, were all much greater for deer fed RC than those fed PRG. The acetate: propionate ratio in rumen volatile fatty acids (VFA) was lower for the RC than the PRG group. It was concluded that the greater fibre digestion in deer fed RC was due to a faster rumen fractional degradation rate and a longer particulate mean retention time in the rumen, and that the very rapid outflow of water from the rumen relative to particulate matter in deer fed RC (5·5:1 ν. 3·8:1) may explain why deer are not susceptible to rumen frothy bloat when grazing RC. One reason for the greater voluntary feed intake (VFI) of deer grazing RC than those grazing PRG may be due to its greater concentration of protein and non-protein cell contents and their more rapid degradation and removal from the rumen.
Developing the Key Attributes for Product Matching Based on the Item's Image Tag Comparison

With the constant growth of the number of products on e-marketplaces, buyers feel hard to find and choose items that would satisfy all their needs and expectations. Search and filtering algorithms of recommender systems, although are striving to help users, still fail quite often due to incomplete and inaccurate description of items. The given work suggests to combine analysis of both item description and item image in order to construct groups of similar items. Since a person can define whether two items are similar or not looking at two images and a brief description, it is suggested to form a set of similar items based on users’ judgments and then to extract the core of keywords for the specific type of products. Further, it is proposed to use the given core to evaluate the similarity of any new item added to the definite group. The case study deals with the building of the core of keywords for sneakers. The developed key attributes allow matching the items with a high precision, thus, proving the effectiveness of the method of the core construction.
Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome.

OBJECTIVE The effect of diet on insulin resistance (IR) in polycystic ovary syndrome (PCOS) is controversial. Thus, we conducted this systematic review and meta-analysis to evaluate whether diet could reduce IR in women with PCOS while providing optimal and precise nutrition advice for clinical practice. DESIGN The search was conducted in eight databases through June 30, 2019. The systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A random-effect model was adopted to calculate the overall effects. RESULTS A total of 19 trials (1193 participants) were included. The analysis showed that diet was significantly related to improvements in IR and body composition (e.g., homeostasis model assessment of insulin resistance (HOMA-IR), fasting insulin (FINS), fasting plasma glucose (FPG), body mass index (BMI), weight, and waist circumference (WC)) in PCOS patients. The Dietary Approaches to Stop Hypertension (DASH) diet and calorie-restricted diets might be the optimal choices for reducing IR and improving body composition, respectively, in the PCOS population. Additionally, the effects were associated with the course of treatment. The longer the duration, the greater the improvement was. Compared with metformin, diet was also advantageous for weight loss (including BMI and weight) and had the same effects on insulin regulation. CONCLUSION Overall, our findings suggest that diet is an effective, acceptable and safe intervention for relieving IR, and professional dietary advice should be offered to all PCOS patients.
Morphogenesis and adhesion of Aureobasidium pullulans

Two strains of the dimorphic fungus Aureobasidium pullulans were grown in liquid and on solid media varying in carbon and nitrogen content, and on leaf surfaces. Hyphae were observed in all systems but comprised a very low proportion (often below quantitative detection) of the total biomass. In liquid media, hyphae were found sparsely and only in the wash-zone on walls of the culture flasks. Yeast phase growth (blastospores) occurred in pH-buffered media that were nutrient balanced, or continuously carbon-limited (fed-batch culture), or carbon-exhausted (batch culture). Blastospores exposed to conditions with limited nitrogen but sufficient organic carbon, or to acidified media, converted to swollen cells and chlamydospores. The latter morphotypes accumulated carbon internally as lipid granules, and then externally as capsular and soluble extracellular polysaccharide. They were cohesive and also adhered more strongly to cellulose membranes overlying agar media or to leaves than did blastospores. Pullulana.
The spatial structure of Antarctic biodiversity

Patterns of environmental spatial structure lie at the heart of the most fundamental and familiar patterns of diversity on Earth. Antarctica contains some of the strongest environmental gradients on the planet and therefore provides an ideal study ground to test hypotheses on the relevance of environmental variability for biodiversity. To answer the pivotal question, “How does spatial variation in physical and biological environmental properties across the Antarctic drive biodiversity? ” we have synthesized current knowledge on environmental variability across terrestrial, freshwater, and marine Antarctic biomes and related this to the observed biotic patterns. The most important physical driver of Antarctic terrestrial communities is the availability of liquid water, itself driven by solar irradiance intensity. Patterns of biota distribution are further strongly influenced by the historical development of any given location or region, and by geographical barriers. In freshwater ecosystems, free water is also crucial, with further important influences from salinity, nutrient availability, oxygenation, and characteristics of ice cover and extent. In the marine biome there does not appear to be one major driving force, with the exception of the oceanographic boundary of the Polar Front. At smaller spatial scales, ice cover, ice scour, and salinity gradients are clearly important determinants of diversity at habitat and community level. Stochastic and extreme events remain an important driving force in all environments, particularly in the context of local extinction and colonization or recolonization, as well as that of temporal environmental variability. Our synthesis demonstrates that the Antarctic continent and surrounding oceans provide an ideal study ground to develop new biogeographical models, including life history and physiological traits, and to address questions regarding biological responses to environmental variability and change.
A Strategy of Trust Management in Social Internet of Things community

: A social Internet of Things (IoT) framework can be seen as a blend of traditional disbursed systemsand informal communities, wherein "matters" self-sufficiently set up social connections as in keeping with the proprietors' interpersonal groups, and look for relied on "matters" which could supply administrations required whilst they arrive into touch with each different deftly. A new search for of the proper item that could offer the desired provider. A newparadigm known as Social Internet of Things has been introduced and proposes the integration of social networkingstandards into the Internet of Things. The beneath idea is that every item can search for the favoured provider the use of itsfriendships, in a allotted way. The cluster among Internet of Things (IoT) and social networks (SNs) allows the relationship of human beings to the ever-present computing universe
Japan.com

Contemporary Japan is in the midst of an identity crisis grounded in conditions of economic, political and social confusion and a lost sense of national direction and purpose. This paper explores the bases of Japan's evolving national political identity. It notes the construction of a sense of Japanese homogeneity and the role of official discourses in the formation of Japan's national identity. The paper argues that internationalisation, cybernetic contacts and community insecurities are undermining the received idea of what it means to be Japanese and posing fundamental challenges to the legitimacy of the contemporary Japanese state.
Juglone effects on seedling growth in intact and coatless seeds of muskmelon

Elongation, fresh and dry weights of muskmelon seedlings (Cucumis melo cv. Ký kavunu) were enhanced by juglone in intact seeds. In the case of coatless seeds, root elongation decreased but fresh and dry weight of the seedlings were increased by juglone. While protein content was slightly increased by juglone in cotyledons of intact seeds, it did not change significantly in coatless seeds. Catechol oxidizing activity of polyphenol oxidase (PPO) enzyme increased in cotyledons of juglone treated intact seeds whereas it did not change significantly in coatless seeds.
Origin and fates of the proepicardium

The embryonic heart initially consists of only two cell layers, the endocardium and the myocardium. The epicardium, which forms an epithelial layer on the surface of the heart, is derived from a cluster of mesothelial cells developing at the base of the venous inflow tract of the early embryonic heart. This cell cluster is termed the proepicardium and gives rise not only to the epicardium but also to epicardium- derived cells. These cells populate the myocardial wall and differentiate into smooth muscle cells and fibroblasts, while the contribution to the vascular endothelial lineage is uncertain. In this review we will discuss the signaling molecules involved in recruiting mesodermal cells to undergo proepicardium formation and guide these cells to the myocardial surface. Marker genes which are suitable to follow these cells during proepicardium formation and cell migration will be introduced. We will address whether the proepicardium consists of a homogenous cell population or whether different cell lineages are present. Finally the role of the epicardium as a source for cardiac stem cells and its importance in cardiac regeneration, in particular in the zebrafish and mouse model systems is discussed.
COMPARACIÓN ENTRE EL POTENCIAL DE LAS REGIONES VARIABLES DEL 16 S rDNA PARA LA IDENTIFICACIÓN DE Lactobacillus spp. (LACTOBACILLIACEAE) Comparing the Potential for Identification of Lactobacillus spp. of 16 S rDNA Variable Regions

s rDNA is used for bacterial identification because its variation rate between species allows differentiation. The gene for this ribosomal subunit has 9 variable regions and some of them give more information than others. We were interested in evaluating the potential for species identification of each region and their combinations. We extracted the V1 to V8 regions of 16s rDNA from different strains and species of Lactobacillus and analyzed them using STAP (ss-RNA Taxonomy Assigning Pipeline) and RDP (Ribosomal Database Project) multiclassifier packages. Phylogenetic trees obtained by maximum likelihood analyses were compared. Classification results show that many regions give the correct genus classification using RDP and STAP, however they are not enough to classify up to the level of species. V5V6 region presents the highest quantity of informative fragments but also present the highest rate of false negatives. V1V3 region presents the highest rate of true positives (species) using STAP and the