Miracle-dz/UniFAR-FTUs huggingface dataset:
Antisense suppression of tau in cultured rat oligodendrocytes inhibits process formation

The microtubule‐associated protein tau is integral to neuronal process development and has a role in the pathogenesis of several neurodegenerative conditions. We examined possible roles for tau in cultured oligodendrocyte process formation by using antisense oligonucleotide treatment. Inhibition of tau synthesis with single oligonucleotides resulted in decreased tau protein levels and significantly shorter cellular processes. Simultaneous use of two nonoverlapping oligonucleotides caused a major reduction in tau levels and severely inhibited process outgrowth. The timing of oligonucleotide addition to oligodendrocyte cultures was important, with addition of antisense at the time of plating into culture having the most significant effect on morphology through reduction of tau expression. © 2008 Wiley‐Liss, Inc.
A new understanding of satisfaction model in e-re-purchase situation

Purpose – The purpose of this paper is to investigate the satisfaction consequences in repurchase situations.Design/methodology/approach – Online travel services are chosen because customers in these types of services had direct contact with firms. A conceptual model of CS‐RPI link is developed and used to test proposed hypotheses. A total of 514 respondents are used to test the proposed model.Findings – The empirical findings indicate that psychological mediators are useful when repurchase situations are considered. The study provides the roles of positive attitude in the formation of CS‐RPI link. Also, three factors: adjusted expectations, trust, and positive attitude, are found to have a significant mediating influence on the link of CS‐RPI.Research limitations/implications – Future researchers attempting to replicate and extend these findings may wish to collaborate with companies marketing products and services online and track customers' actual behaviors. This would be an excellent way to validate t.
Liquidity in Currency Options Market in India

Liquidity being an elusive concept is often difficult to measure, and it becomes even vaguer in currency options market which provides investors an alternative to hedge against foreign exchange fluctuations. Over past few years since the starting of trading of currency options contracts on US dollar-Indian rupee in Indian exchanges began, the currency market has grown significantly. Currency options trades at the National Stock Exchange of India is ranked first among exchanges across the world in terms of volume traded and number of trades, and third in terms of traded value (WFE, 2011). Hence, in this paper, we examine the systematic component of liquidity as source of price changes in the Indian currency options market. Using daily data on trading volume, value, open interest, and spot USD-INR exchange rate from November 2010 to October 2012, we compute the Amihud ratio (Amihud, 2002) as a proxy for market-level illiquidity in the Indian currency options market. Vector error correction model (VECM) estimation approach is employed to examine the causal relationship among illiquidity, volatility, returns and speculation in currency options market. Specifically, we aim to address the following issues with respect to the currency options market for USD-INR: (1) What makes the liquidity in the currency options market suddenly dry up? (2) How is the liquidity in the currency options market related to volatility? and (3) Does speculators’ capital drive the currency options market?
Japanese Kanji-calligraphic font design using onomatopoeia utterance

Onomatopoeias are useful tool to communicate intuitively and conveniently among people. This paper focused on the utility of onomatopoeias and proposed a design supporting system of Japanese Kanji-calligraphic “Shodo” font using onomatopoeia utterance. The system can generate a variety of scratched- and blurred-look design of “Shodo”. In order to realize the design, the system utilized the correspondence between onomatopoeias and the scratched- and blurred-look. This paper reported the concept and the architecture of the proposed system. And we demonstrated some output examples generated by the system.
Assessing the vulnerability of private label brands

Private label brands may be in danger as a result of recent changes in the marketing strategies used by private label firms. The primary competitive advantage of private label brands, good quality at low prices, may be lost if private label firms continue to modify and expand how their brands are marketed. Specifically, changes in private label brands′ advertising, packaging, sales promotion, and product improvement strategies indicate that private label brands are moving closer than ever to manufacturer brand status. To the extent that these changes result in higher average retail prices and/or lower gross margins for retailers, the advantages of private brands to both consumers and distributors will diminish, illustrating that the historical “wheel of retailing” hypothesis may be applicable to private label brands. Investigates the aforementioned trends and provides suggestions for manufacturers and retailers for future brand management strategies.
Lockup Provision and Institution Investors Trading

The lock-up provision conveys important information about the ex-ante risk of an IPO. Using a unique trading data in pre-IPO market and a unique data of exact days of withdrawing lockup shares, we are able to test the trading behavior of institutional investors around the lockup announce day and expiration day using a sample of 218 IPOs firms from 2005 to 2011 in Taiwan. We are able to find that the abnormal returns of institutional investors are insignificant around the lockup announce day. Second, the relationship between the net buying and selling of institutional investor and cumulative returns around announce day is insignificant. Also, the relationship between lockup ratio and institutional investor trading around, and the relationship between the lockup ratio and initial return of IPOs are all insignificant. This implies that announcement of lockup ratio carries no information.We then examine whether the trading of institutional investors around the withdrawing of lockup shares affects long term performance. We do find that there is a positive relationship between foreign institution trading and ROE for one year after IPO. It implies that the trading behavior of institution investors around lockup expiration day contains information of long term performance.
Direct‐developing sea urchins and the evolutionary reorganization of early development

The evolution of development can be made accessible to study by exploiting closely related species that exhibit distinct ontogenies. The direct‐developing sea urchin Heliocidaris erythrogramma is closely related to indirect‐developing sea urchins that develop via a feeding larval stage. Superficial consideration would suggest that simple heterochronies resulting in loss of larval features and acceleration of adult features could explain the substitution of direct for indirect development. However, our experiments show that early development has in fact been extensively remodeled, with modified localization of maternal determinants coupled with dissociation of cell cleavage from axis formation resulting in novel patterns of cell lineage differentiation and fate map. Gene expression has undergone concomitant changes.
Employer branding and its influence on managers

Purpose – The paper seeks to explore the role of the employer brand in influencing employees' perceived differentiation, affinity, satisfaction and loyalty – four outcomes chosen as relevant to the employer brand.Design/methodology/approach – A multidimensional measure of corporate brand personality is used to measure employer brand associations in a survey of 854 commercial managers working in 17 organisations. Structural equation modelling is used to identify which dimensions influence the four outcomes. Models are built and tested using a calibration sample and tested on two validation samples, one equivalent to the calibration sample and another drawn from a single company.Findings – Satisfaction was predicted by agreeableness (supportive, trustworthy); affinity by a combination of agreeableness and (surprisingly) ruthlessness (aggressive, controlling); and perceived differentiation and loyalty by a combination of both enterprise (exciting, daring) and chic (stylish, prestigious). Competence (reliable.
Content Aggregation in the Age of Online Video: An Analysis of the Impact of Internet Distribution on the Television Business

Abstract This article examines the economic impact of Internet distribution on the television industry and the strategic implications for incumbent broadcasters. It shows that a useful way of grappling with the structural changes underway is to consider the changing nature of aggregation. Far from contracting, it is argued, the new supply chain for online television is extending as the aggregation function, broadly understood to encompass new activities performed by a whole host of new online video aggregators, is becoming more layered. The nature and scale of the threats facing incumbent broadcasters, and their strategic responses are discussed.
Role of Neuroinflammation in Evolution of Childhood Epilepsy

Until a decade ago, epilepsy research had focused mainly on alterations of neuronal activities and excitability. Such neurocentric emphasis has neglected the role of glia and involvement of inflammation in the pathogenesis of epilepsy. It is becoming clear that immune and inflammatory reactions do occur in the brain despite the brain’s lack of conventional lymphatic drainage and graft acceptance and the presence of vascular brain barrier that tightly regulates infiltration of blood monocytes and lymphocytes. The critical roles of brain-resident immune mediators and of brain-infiltrating peripheral leukocytes are increasingly recognized. Inflammatory processes, including activation of microglia and astrocytes and production of proinflammatory cytokines and related molecules, occur in human epilepsy as well as in experimental models of epilepsy. Immune mechanism that underlies evolution of drug-resistant epilepsy and epileptic encephalopathy represents a new target and will aid in development of novel immunotherapeutic drugs and therapies against the key constituents in immune pathways.
Shared services - Implementation and continuous evolution (Article 2 of 3)

Purpose: Now that an organisation understands the concept of shared services (Article 1), it needs to implement shared services as a business model. The purpose of this second article in the trilogy is to describe the phases during the implementation process, as well as the various models through which a shared services business unit will evolve to continuously add value to the organisation. Methodology: A comprehensive literature study was conducted in order to: - Determine the steps in implementing a shared services business model, - Determine the various models associated with a shared services business unit, - Determine how the continuous evolution of shared services results in moving from one shared services model to the next shared services model. Findings: In this article, a framework is generated to help organisations understand the various phases and steps it needs to go through to successfully implement a shared services business unit. This work has further potential: when applied correctly, organisations will provide a business environment where effectiveness and efficiency is a given. Implications: This article presents the context for organisations to implement a shared services business model and to continuously evolve from one shared services business model to the other to create value for the organisation. The findings are important for organisations that are in the process of implementing or have implemented shared services, as they can easily stagnate and fall into the trap of centralisation. Value: This article provides an understanding of what is required for the successful implementation of shared services. This value is further enhanced through continuous evolution from a basic shared services business model to the virtual shared services business model and beyond.
Analytic posteriors for Pearson's correlation coefficient

Pearson's correlation is one of the most common measures of linear dependence. Recently, Bernardo (11th International Workshop on Objective Bayes Methodology, 2015) introduced a flexible class of priors to study this measure in a Bayesian setting. For this large class of priors, we show that the (marginal) posterior for Pearson's correlation coefficient and all of the posterior moments are analytic. Our results are available in the open‐source software package JASP.
Multiple biogeographical barriers identified across the monsoon tropics of northern Australia: phylogeographic analysis of the brachyotis group of rock‐wallabies

The monsoon tropics of northern Australia are a globally significant biodiversity hotspot, but its phylogeography is poorly known. A major challenge for this region is to understand the biogeographical processes that have shaped the distribution and diversity of taxa, without detailed knowledge of past climatic and environmental fluctuations. Although molecular data have great potential to address these questions, only a few species have been examined phylogeographically. Here, we use the widely distributed and abundant short‐eared rock‐wallaby (Petrogale brachyotis; n = 101), together with the sympatric monjon (P. burbidgei; n = 11) and nabarlek (P. concinna; n = 1), to assess historical evolutionary and biogeographical processes in northern Australia. We sequenced ∼1000 bp of mitochondrial DNA (control region, ND2) and ∼3000 bp of nDNA (BRCA1, ω‐globin and two anonymous loci) to investigate phylogeographic structuring and delineate the time‐scale of diversification within the region. Our results indicate multiple barriers between the Top End (Northern Territory) and Kimberley (Western Australia), which have caused divergence throughout the Plio‐Pleistocene. Eight geographically discrete and genetically distinct lineages within the brachyotis group were identified, five of which are separated by major river valleys (Ord, Victoria, Daly), arid lowlands and discontinuous sandstone ranges. It is likely that these barriers have similarly influenced genetic structure in other monsoonal biota.
Balancing power and dependency in buyer-supplier relationships

Attainment of supply chain integration is a major challenge for organisations, given the power and dependency that exists between suppliers and customers. This research explored the extent to which New Zealand organisations are integrated with their suppliers, via development of a purchasing portfolio model and consideration of 141 supplier-buyer relationships in six dissimilar organisations. The stepwise procedure enables the managers to analyse their supplier portfolio and to identify their most appropriate supplier relationship strategy based on considerations of power and dependency. The research indicates that: 1 New Zealand organisations are weakly integrated with their suppliers 2 they frequently do not comprehend, and thus mismanage, their supplier relationships 3 power and dependency ultimately limit the level of achievable integration.
Buscopan or Glucagon for Endoscopic Cannulation of Ampulla of Vater?

The number of intravenous injections of hyoscine-N-butylbromide (Buscopan) or glucagon required to maintain relaxation of the duodenum during endoscopic retrograde cholangiopancreatography (ERCP) were compared in a double blind trial of 55 patients. There was no significant difference in the number of injections. Serum amylase levels after the use of both relaxants were compared in 50 patients undergoing ERCP. No significant difference in the levels of hyperamylasaemia were found.
Proceedings of the ACM MobiCom workshop on Security and privacy in mobile environments

It is our great pleasure to welcome you to the 2014 International Workshop on Security and Privacy Aspects of Mobile Environments -- SPME'14. As the TPC chairs and organizers on its first year, we hope SPME will create the tradition of being a forum for presentation of early research results and candid discussions on issues related to security & privacy including systems and theory results for communications, devices and applications security in mobile environments. The mission of the workshop is to timely share novel ideas and early results that might eventually fulfill the security and privacy needs of stakeholders, and help the research community identify promising directions for future research and development. In its first year, the call for papers for the workshop attracted 12 submissions from Asia, Australia, Europe and the United States. The program committee accepted 7 high-quality papers that cover a variety of topics, including analysis of privacy risks to users of mobile devices, new privacy preserving protocols for behavioral targeting and access control techniques in mobile environments. We hope that the proceedings will serve as a valuable reference for security researchers and developers. In addition to the proceedings, the workshop program includes a panel discussion and a keynote talk. We encourage attendees to attend the keynote and invited talk presentations as well as the technical presentation sessions.
Gold nanoparticles: opportunities and challenges in nanomedicine

Importance of the field: Site-specific drug delivery is an important area of research that is anticipated to increase the efficacy of the drug and reduce potential side effects. Owing to this, substantial work has been done developing non-invasive and targeted tumor treatment with nanoscale metallic particles. Areas covered in this review: This review focuses on the work done in the last few years developing gold nanoparticles as cancer therapeutics and diagnostic agents. However, there are challenges in using gold nanoparticles as drug delivery systems, such as biodistribution, pharmacokinetics and possible toxicity. Approaches to limit these issues are proposed. What the reader will gain: Different approaches from several different disciplines are discussed. Potential clinical applications of these engineered nanoparticles are also presented. Take home message: As a result of their unique size-dependent physicochemical and optical properties, adaptability, subcellular size and biocompatibility, these nanosized carriers offer a suitable means of transporting small molecules as well as biomacromolecules to diseased cells/tissues.
X-ray-induced inhibition of DNA synthesis in Chinese hamster ovary, human HeLa, and Mouse L cells.

An X-ray dose of 500 rad inhibits DNA synthesis in Chinese hamster ovary (CHO) cells, in HeLa S3 cells, and in mouse L cells. In no case can the inhibition we observed be explained on the basis of a "pool effect" or any other process that causes deficient use of exogenously supplied DNA precursors. In all cases the inhibition is mediated by a decrease in replicon initiation processes. Since this inhibition is observed at doses too low to affect individual replicons, we hypothesize that a single hit within a cluster of replicons in some manner blocks the initiation of all replicons within the cluster.
Unique Case with Seizures after Prolonged Use of Camphor Crème in Elderly Patient

Camphor is a pleasant smelling cyclic ketone of the hydro aromatic terpene group. The mechanism by which camphor produces toxicity is unknown. Within a period of 5 to 15 minutes, patients commonly complain of mucus membrane irritation, nausea, vomiting, and abdominal pain. Generalized tonic-clonic convulsions are often the first sign of significant toxicity and can occur soon after ingestion. Central nervous system depression is commonly seen, such as headache, dizziness, confusion, agitation, anxiety, hallucinations, myoclonus, and hyperreflexia.
Firewall Policy Query Language for Behavior Analysis

Firewalls are one of the most important devices used in network security today. Their primary goal is to provide protections between parties that only wish to communicate over an explicit set of channels, expressed through protocols. These channels are implemented and described in a firewall using a set of rules, collectively referred to as a firewall policy. However, understanding the policy that a particular firewall is enforcing has become increasingly difficult. Many industry forces are converging that cause managing these devices to be much more complex than the premise of rules suggest. Recently work has been done modeling a firewall policy in a concise and efficient data structure referred to as a Firewall Policy Diagram (FPD). The structure facilitates the canonical representation of a policy as well as human comprehension of the policy. This work builds on top of the data structure to provide a language for asking the data structure questions about the space that is represented in a policy, either the accepted, denied, or remaining traffic. Firewall Policy Query Language (FPQL) is a language loosely modeled after the Structured Query Language often seen related to database systems and relational algebra. It essentially provides a group of set mathematics based operators for deriving knowledge from a very large solution space. This work seeks to provide a simple, yet powerful, query language that is useful for human comprehension of a firewall policy as represented by an FPD.
Association of Sleep Duration with Arterial Blood Pressure Profile of Gujarati Indian Adolescents

Background and Aim: Recently, National Health and Nutritional Examination Survey-1 data analysis found short sleep duration as a risk factor for hypertension in the U.S. population. However, since ethnic differences exist in the aetiopathogenesis of diseases, the current study was undertaken to study the effect of sleep duration on the blood pressure profile of Gujarati Indian adolescents. Materials and Methods: A cross-sectional study was conducted on 489 Gujarati Indian adolescents of age group 16-19 years studying in school and colleges in the local population. The participants were assessed for their sleep duration, physical activity status, body composition, blood pressure profile and cardiovascular reactivity. The sleep duration was reported by the subjects as the number of hours they slept on most of the nights in a week over the last one year. The observations of the study were then analyzed after grouping them into: 1) Adequate Sleep Duration at Night, ASDN (≥7 hrs) and 2) Inadequate Sleep Duration at Night, ISDN (<7 hrs) groups. Student's unpaired t-test was used to study if any significant difference (P< 0.05) existed between the groups. Results: No significant difference was found in Systolic blood pressure, Diastolic blood pressure, Pulse pressure and Mean arterial pressure between the ASDN group and the ISDN group. Physical activity status also did not differ between the two groups. However, adolescents of ISDN group showed a significantly higher level of adiposity and cardiovascular reactivity as compared to adolescents of ASDN group. Conclusion: Although short sleep duration is associated with a higher level of adiposity and cardiovascular reactivity in Gujarati Indian adolescents, it does not affect the resting blood pressure profile of these adolescents. However, longitudinal studies would be required to observe if the changes in adiposity and cardiovascular reactivity affect these adolescents in later life.