Miracle-dz/UniFAR-FTUs huggingface dataset:
Simulation-Based Function Selection in Approximate Dynamic Programming

Many approximate dynamic programming approaches replace the value function of a dynamic program with a lower-dimensional function, then use some method to fit the coefficients in the approximation. The resulting accuracy is governed by the basis functions, or features, used. We propose a method for selecting basis functions from a large set of candidate functions by minimizing a form of Bellman error on a simulated trajectory. An efficient algorithm is proposed to solve the resulting least squares problem. The method is tested in combination with approximate linear programming on average cost queueing network problems. It performs much better than random selection of functions.
ANTIHYPERGLYCEMIC POTENTIAL OF SESAMUM INDICUM (LINN) SEEDS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Background: In the present study, we have evaluated the hypoglycaemic effects of ethanolic extract of Sesamum indicum (Lin) seeds by analyzing the glucose, insulin, haemoglobin, glycosylated haemoglobin and hepatic glycogen levels. Methods: Twenty four Wistar albino rats of 200-250 g each were grouped into 4 groups with six rats in each group (control, diabetic, diabetic treated and standard drug -glibenclamide treated). After treatment for 8 weeks, the animals were sacrificed and the biochemical parameters like blood glucose, serum insulin, hemoglobin, glycosylated hemoglobin, liver glycogen levels were measured. Results: Blood glucose and glycosylated hemoglobin levels were significantly increased whereas the serum insulin and hemoglobin levels were significantly decreased in diabetic rats and reverted to near normal in treated groups. The liver glycogen level was significantly decreased in diabetic rats and reverted to near normal in treated groups. Conclusion: The above results shows that the ethanolic extract of Sesamum indicum seeds has a potential effect to control hyperglycemia in streptozotocin induced diabetic rats.
The Human Skin-Derived Precursors for Regenerative Medicine: Current State, Challenges, and Perspectives

Skin-derived precursors (SKPs) are an adult stem cell source with self-renewal and multipotent differentiation. Although rodent SKPs have been discussed in detail in substantial studies, human SKPs (hSKPs) are rarely reported. Understanding the biological properties and possible mechanisms underlying hSKPs has important implications for regenerative medicine particularly clinical applications, as human-derived sources are more suitable for clinical transplantation. The finding that hSKPs derivatives, such as neural and mesodermal progeny, have both in vitro and in vivo function without any genetical modification makes hSKPs a trustable, secure, and accessible resource for cell-based therapy. Here, we provide an overview of hSKPs, describing their characteristics, originations and niches, and potential applications. A comparison between traditional and innovative culture methods used for hSKPs is also introduced. Furthermore, we discuss the challenges and the future perspectives towards the field of hSKPs. With this review, we hope to point out the current stage of hSKPs and highlight the problems that remain in this field.
Radiation-Induced Sarcoma Originating in Recurrent Juvenile Nasopharyngeal Angiofibroma

Juvenile nasopharyngeal angiofibroma is a benign disease affecting young males with a propensity to invade intracranially and into the orbit along preformed pathways. Complete surgical excision is the mainstay of management. Patients with multiple recurrences along with tumour extension into skull base and orbit can be considered for external beam radiation as either adjuvant or definitive treatment. Possibility of radiation-induced malignancy has been speculated by many authors, proof of which exists in only two studies so far. This report focuses on radiation-induced leiomyosarcoma in a patient with recurrent juvenile nasopharyngeal angiofibroma.
CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers

The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance. Here, the expression of PD-L1, PD-L2, CD80, and CD86 was evaluated at the mRNA level in 94 patients affected by papillary thyroid carcinoma (PTC) and 11 patients affected by anaplastic thyroid carcinoma (ATC). Variations in the mRNAs in PTC patients were then correlated with clinicopathological features. The expression of all genes was deregulated in PTC and ATC tissues compared to normal tissues. In particular, the downregulation of CD80 was observed above all in ATC. In addition, the increased expression of CD80 associated with longer disease-free survival in PTC. Higher expression of PD-L1 associated with the classical histological variant and with the presence of BRAFV600E mutation in PTC. The increased PD-L2 expression correlated with BRAFV600E mutation and lymph node metastasis, while its lower expression correlated with the follicular PTC variant. The latter was also associated with the CD80 downregulation, which was also related to the absence of lymph node metastasis. In conclusion, we documented the overall dysregulation of PD-1 and CTLA-4 ligands in PTC and ATC tissues and a possible prognostic value for CD80 gene expression in PTC.
Pain Complaints in Patients Undergoing Orthognathic Surgery

The aim of this retrospective study was to assess the frequency of orofacial (nonodontogenic, neuropathic, or atypical) and temporomandibular joint (TMJ) and/or masticatory muscle pain in orthognathic patients in a tertiary institution. A total of 286 consecutive patients undergoing sagittal split osteotomy from 2014 to 2016 were included. Thirty-nine (13.6%) patients presented with TMJ pain and 10 (3.5%) with orofacial nonodontogenic pain before orthognathic surgery; 79.6% (39/49) of these patients had no pain 1 year after surgery. Twenty-nine patients (12.2%) with no preoperative orofacial pain and 22 (9.3%) without preoperative TMJ pain presented with pain 1 year after surgery. Fifty-one (17.8%) of the 286 patients treated for orthognathic cases at our center over the 3-year period presented with pain 1 year after surgery. Most patients were managed conservatively with nonsurgical therapeutic modalities including counseling, physical therapy, warmth application, and bilateral chewing and splint therapy. In patients with TMJ pain refractory to conservative treatment, arthroscopic surgery was advised and successful in all patients for both pain reduction and improvement of the maximal interincisal opening. TMJ symptoms do develop after orthognathic surgery in patients with and without a previous history of TMJ complaints. Most patients can be managed with nonsurgical therapeutic modalities.
&agr;-Expansin EXPA4 Positively Regulates Abiotic Stress Tolerance but Negatively Regulates Pathogen Resistance in Nicotiana tabacum

Since they function as cell wall-loosening proteins, expansins can affect plant growth, developmental processes and environmental stress responses. Our previous study demonstrated that changes in Nicotiana tabacum α-expansin 4 (EXPA4) expression affect the sensitivity of tobacco to Tobacco mosaic virus [recombinant TMV encoding green fluorescent protein (TMV-GFP)] infection by Agrobacterium-mediated transient expression. In this study, to characterize the function of tobacco EXPA4 further, EXPA4 RNA interfernce (RNAi) mutants and overexpression lines were generated and assayed for their tolerance to abiotic stress and resistance to pathogens. First, the differential phenotypes and histomorphology of transgenic plants with altered EXPA4 expression indicated that EXPA4 is essential for normal tobacco growth and development. By utilizing tobacco EXPA4 mutants with abiotic stress, it was demonstrated that RNAi mutants have increased hypersensitivity to salt and drought stress. In contrast, the overexpression of EXPA4 in tobacco conferred greater tolerance to salt and drought stress, as indicated by less cell damage, higher fresh weight, higher soluble sugar and proline accumulation, and higher expression levels of several stress-responsive genes. In addition, the overexpression lines were more susceptible to the viral pathogen TMV-GFP when compared with the wild type or RNAi mutants. The induction of the antioxidant system, several defense-associated phytohormones and gene expression was down-regulated in overexpression lines but up-regulated in RNAi mutants when compared with the wild type following TMV-GFP infection. In addition, EXPA4 overexpression also accelerated the disease development of Pseudomonas syringae DC3000 on tobacco. Taken together, these results suggested that EXPA4 appears to be important in tobacco growth and responses to abiotic and biotic stress.
A Gene-Based Positive Selection Detection Approach to Identify Vaccine Candidates Using Toxoplasma gondii as a Test Case Protozoan Pathogen

Over the last two decades, various in silico approaches have been developed and refined that attempt to identify protein and/or peptide vaccines candidates from informative signals encoded in protein sequences of a target pathogen. As to date, no signal has been identified that clearly indicates a protein will effectively contribute to a protective immune response in a host. The premise for this study is that proteins under positive selection from the immune system are more likely suitable vaccine candidates than proteins exposed to other selection pressures. Furthermore, our expectation is that protein sequence regions encoding major histocompatibility complexes (MHC) binding peptides will contain consecutive positive selection sites. Using freely available data and bioinformatic tools, we present a high-throughput approach through a pipeline that predicts positive selection sites, protein subcellular locations, and sequence locations of medium to high T-Cell MHC class I binding peptides. Positive selection sites are estimated from a sequence alignment by comparing rates of synonymous (dS) and non-synonymous (dN) substitutions among protein coding sequences of orthologous genes in a phylogeny. The main pipeline output is a list of protein vaccine candidates predicted to be naturally exposed to the immune system and containing sites under positive selection. Candidates are ranked with respect to the number of consecutive sites located on protein sequence regions encoding MHCI-binding peptides. Results are constrained by the reliability of prediction programs and quality of input data. Protein sequences from Toxoplasma gondii ME49 strain (TGME49) were used as a case study. Surface antigen (SAG), dense granules (GRA), microneme (MIC), and rhoptry (ROP) proteins are considered worthy T. gondii candidates. Given 8263 TGME49 protein sequences processed anonymously, the top 10 predicted candidates were all worthy candidates. In particular, the top ten included ROP5 and ROP18, which are T. gondii virulence determinants. The chance of randomly selecting a ROP protein was 0.2% given 8263 sequences. We conclude that the approach described is a valuable addition to other in silico approaches to identify vaccines candidates worthy of laboratory validation and could be adapted for other apicomplexan parasite species (with appropriate data).
Improved Post-processing of Eddy-Covariance Data to Quantify Atmosphere–Aquatic Ecosystem CO2 Exchanges

The capture of carbon by aquatic ecosystems and its sequestration in sediments has been studied as a potential method for mitigating the adverse effects of climate change. However, the evaluation of in situ atmospheric CO2 fluxes is challenging because of the difficulty in making continuous measurements over areas and for periods of time that are environmentally relevant. The eddy covariance method for estimating atmospheric CO2 fluxes is the most promising approach to address this concern. However, methods to process the data obtained from eddy covariance measurements are still being developed, and the estimated air-water CO2 fluxes have large uncertainties and differ from those obtained using conventional methods. In this study, we improved the post-processing procedure for the eddy covariance method to reduce the uncertainty in the measured air-water CO2 fluxes. Our procedure efficiently removes low-quality fluxes using a combination of filtering methods based on the received signal strength indicator of the eddy covariance sensor, the normalized standard deviation of atmospheric CO2 and water vapor concentrations, and a high-pass filter. The improved eddy covariance fluxes revealed diurnal and semi-diurnal cycles and a significant relationship with water fCO2, patterns that were not observed from the results before filtering. Although there were still differences with indirect conventional measurements like the bulk formula method, the methods used in this study should improve the accuracy of carbon flow estimates at sites with complex terrains like coastal areas.
Hypofractionated whole breast irradiation is cost-effective-but is that enough to change practice?

Breast cancer is both the most commonly diagnosed new cancer and the most expensive cancer to treat in the United States (US) (1). It was estimated to account for the largest share of national cancer expenditures in 2010, at $16.5 billion, and is projected to increase to $20.5 billion by 2020 based on US population growth alone (2). In the current climate of unsustainable rising healthcare costs, breast cancer and its treatment present ample opportunities to favorably bend the cost curve while positively benefitting patients.
Sequential Imaging in Patient With Suspected Menière's Disease Identifies Endolymphatic Sac Tumor.

OBJECTIVE The standard evaluation of patients with suspected Menière's disease (MD) includes initial imaging to rule out tumors of the temporal bone. Few guidelines, however, advocate sequential imaging. We propose that sequential imaging may reveal other etiologies of auditory and vestibular symptoms as demonstrated in a patient with an endolymphatic sac tumor that was originally diagnosed Menière's after initial imaging. PATIENTS One patient with MD and initially unremarkable imaging. Repeat imaging several years after diagnosis after additional symptoms demonstrated interval development of an endolymphatic sac tumor (ELST). INTERVENTIONS Resection of endolymphatic sac tumor. MAIN OUTCOME MEASURES 1) Audiometry, 2) temporal bone imaging, and 3) otopathology RESULTS:: A 45-year-old man with diagnosis of asymmetric sensorineural hearing loss and intermittent vertigo underwent temporal bone magnetic resonance imaging that did not demonstrate any causative lesions. After an episode of sudden sensorineural hearing loss 4 years after initial presentation, repeat imaging was obtained. Magnetic resonance imaging and surgical resection confirmed diagnosis of ELST. The patient had no history of von Hippel-Lindau disease. CONCLUSIONS A patient with a longstanding diagnosis of MD demonstrated interval development of an ELST. While ELSTs are rare, the study raises the question regarding whether interval imaging is indicated in patients with MD.
The Effect of Low Protein Energy-Rich Diets on Plasma Hepatic Markers, Hepatic Damage, and Discrimination Reversal Learning in Young Female Chicks

Consumption of low protein energy-rich (LPER) diets increases susceptibility to metabolic disease in mammals, such as hepatic damage, and can have an adverse effect on cognition. However, the effects of these diets on both physical and mental welfare have not been investigated in domestic meat chickens. Female chicks received a low protein energy-rich or a standard control diet from 21 to 51 days of age. The effects of these dietary manipulations on plasma hepatic markers for liver damage, liver necropsy, and learning a visual discrimination reversal task were assessed. Birds given access to LPER diets weighed less than chicks that had access to the control diets. All chicks had post-mortem signs of hepatic hemorrhage/increased liver color scores and aspartate aminotransferase (AST) levels above 230 U/L indicative of hepatic damage in birds. The LPER diet had no impact on the performance of female chicks when learning to distinguish colors in a reversal visual discrimination task. The present study suggests that liver damage does not become worse when feeding LPER or impact visual reversal learning in female meat-type chickens. However, the high incidence of liver cell damage/liver hemorrhage, and “abnormal” AST activities are of concern in female broiler chicks across both diets, and suggests that the health of modern meat-type genotypes needs to be improved.
Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice

We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.
Cognitive and neural facets of dissociation in a traumatized population.

Dissociative phenomena are frequently experienced by psychologically traumatized people. However, little is known about the cognitive profiles of highly dissociative traumatized individuals, and corresponding patterns of neural connectivity when attentional networks are engaged in the context of emotion. One hundred seventeen traumatized women completed the multiscale dissociation inventory (MDI) and neuropsychological testing; MDI scores were used to classify high- and low-dissociative participants. Forty-six participants also underwent fMRI during performance of an attentional control task that incorporates emotionally distracting images (Affective Number Stroop; ANS). Compared to low-dissociative participants, high-dissociative participants demonstrated better performance on an executive functioning task (F1,111 = 4.64, p = .03), worse performance on a task of visual memory (F1,111 = 9.52, p = .003), and similar performance on all other neuropsychological measures. In addition, dissociative symptoms were negatively correlated with functional connectivity between the amygdala and right anterior insula in response to trauma-related ANS trials. These findings indicate that highly dissociative traumatized people experience difficulties with attentional control in the context of emotionally evocative stimuli, but in a neutral context, their overall cognitive profiles are similar to low-dissociative people. Highly dissociative participants also demonstrated weaker connectivity between the amygdala and insula in response to trauma-relevant images. Evocative, trauma-relevant stimuli appear to disrupt neutral networks involved with attention to salient cues and interoception in highly dissociative traumatized individuals. (PsycINFO Database Record
Immunological failure in HIV-infected adults from 2003 to 2015 in Southwest Ethiopia: a retrospective cohort study

Objective To assess the prevalence, trend and associated factors for immunological failure (IF), and the magnitude of antiretroviral therapy (ART) shift among adults infected with HIV in Southwest Ethiopia. Setting A retrospective cohort study was undertaken using the data from ART clinic at Jimma University Teaching Hospital from 21 June 2003 to 15 March 2015. Participants Retrospective analysis of 4900 HIV-infected adult patient records dating from June 2003 to March 2015 was conducted. Primary outcome measure The primary outcome was IF defined when cluster for differentiation 4 (CD4) count falls to the baseline (or below) or persistent CD4 levels below 100 cells/mm3 after 6 months of ART treatment. The analyses included descriptive and inferential statistics. Results 546 (19.5%) adults had developed clinical failure (CF), 775 (19.7%) adults had developed IF and 1231 (25.1%) had developed either CF or IF or both. The prevalence of IF was consistently high throughout the decade. Age 25 to ≤50 years adjusted OR (AOR 1.5, 9% CI 1.2 to 2.4), being female (AOR 1.8, 95% CI 1.3 to 1.9), late presenter for HIV care (AOR 2.2, 95% CI 1.6 to 2.7) and having baseline CD4 count below 200 cells/mm3 (AOR 5.5, 95% CI 4.1 to 7.4), and having no history of HIV testing before diagnosis (AOR 0.7, 95% CI 0.5 to 0.9) were the predictors for IF. Only 29 (0.9%) adults infected with HIV were shifted to second-line ART regimen. Conclusions The magnitude of CF or IF or both was found significant and consistently high throughout the calendar year although ART shift was found minimal. HIV-infected adult patients with IF were early age adults, females, late presenters for HIV care, and those who had low baseline CD4 counts and history of HIV testing before diagnosis.
Disorganized Patterns of Sulcal Position in Fetal Brains with Agenesis of Corpus Callosum

Fetuses with isolated agenesis of the corpus callosum (ACC) are associated with a broad spectrum of neurodevelopmental disability that cannot be specifically predicted in prenatal neuroimaging. We hypothesized that ACC may be associated with aberrant cortical folding. In this study, we determined altered patterning of early primary sulci development in fetuses with isolated ACC using novel quantitative sulcal pattern analysis which measures deviations of regional sulcal features (position, depth, and area) and their intersulcal relationships in 7 fetuses with isolated ACC (27.1 ± 3.8 weeks of gestation, mean ± SD) and 17 typically developing (TD) fetuses (25.7 ± 2.0 weeks) from normal templates. Fetuses with ACC showed significant alterations in absolute sulcal positions and relative intersulcal positional relationship compared to TD fetuses, which were not detected by traditional gyrification index. Our results reveal altered sulcal positional development even in isolated ACC that is present as early as the second trimester and continues throughout the fetal period. It might originate from altered white matter connections and portend functional variances in later life.
Can cerebral microbleeds cause an acute stroke syndrome?

GRE T2* MRI sequences are sensitive to tiny areas of previous bleeding (termed cerebral microbleeds [CMBs])1 due to the paramagnetic effects of blood degradation products including oxyhemoglobin and hemosiderin. CMBs are common and may be a prognostic marker of recurrent intracerebral hemorrhage,2 including antithrombotic related hemorrhage.3 Studies suggest that the chronic accumulation of CMBs may have an effect on anatomically distributed cerebral functions including cognition.4 As microbleeds cause focal damage to the brain tissue,5 acutely developing microbleeds might be expected to cause focal symptoms. We report 2 cases of acute focal neurologic symptoms and clinical signs that in each case appeared to be due to a CMB. ### Case 1 A 69-year-old right-handed man with known hypertension awoke feeling dizzy and unsteady (“as if the room was spinning around him”) and had numbness around his mouth and on his right cheek. When examined 2.5 hours later, his systolic blood pressure was >200 mm Hg and he had a right VII lower motor neuron palsy, gait ataxia, and gaze-evoked nystagmus on right gaze. An urgent CT head and CT angiogram showed no focal abnormality (figure e-1). MRI using a Siemens 1.5 Tesla scanner was performed on the same day. GRE T2*-weighted sequences showed a CMB centered …