Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of low-level laser in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial.

INTRODUCTION Low-level laser therapy (LLLT) is thought to have an analgesic effect as well as a biomodulatory effect on microcirculation. This study was designed to examine the pain-relieving effect of LLLT and possible microcirculatory changes measured by thermography in patients with knee osteoarthritis (KOA). MATERIALS AND METHODS Patients with mild or moderate KOA were randomized to receive either LLLT or placebo LLLT. Treatments were delivered twice a week over a period of 4 wk with a diode laser (wavelength 830 nm, continuous wave, power 50 mW) in skin contact at a dose of 6 J/point. The placebo control group was treated with an ineffective probe (power 0.5 mW) of the same appearance. Before examinations and immediately, 2 wk, and 2 mo after completing the therapy, thermography was performed (bilateral comparative thermograph by AGA infrared camera); joint flexion, circumference, and pressure sensitivity were measured; and the visual analogue scale was recorded. RESULTS In the group treated with active LLLT, a significant improvement was found in pain (before treatment [BT]: 5.75; 2 mo after treatment : 1.18); circumference (BT: 40.45; AT: 39.86); pressure sensitivity (BT: 2.33; AT: 0.77); and flexion (BT: 105.83; AT: 122.94). In the placebo group, changes in joint flexion and pain were not significant. Thermographic measurements showed at least a 0.5 degrees C increase in temperature--and thus an improvement in circulation compared to the initial values. In the placebo group, these changes did not occur. CONCLUSION Our results show that LLLT reduces pain in KOA and improves microcirculation in the irradiated area.
Influence of the North Atlantic Oscillation on Mediterranean deep-sea shrimp landings

Recent studies have shown that the population dynamics of deep-sea organisms are affected by coupling between surface oceanic processes and energy, or trophic resources, reaching the sea floor. I analysed the correlation between the landings of a deep-sea shrimp (Aristeus anten- natus) in Catalonia (NW Mediterranean) and the climatic indices of the annual North Atlantic Oscil- lation (NAO) and winter NAO between 1971 and 2007. I show that the size of landings is significantly correlated with the NAO and with the winter NAO, with 2 and 3 yr lags in both cases. Considering that around 60% of the landings comprise 2 to 3 yr old females, my results suggest that climatic con- ditions over the western Mediterranean (especially in winter) influence the year-class strength of this deep-sea shrimp, fished from 600 to 800 m depth.
Vers une meilleure interopérabilité des données géographiques françaises sur le Web de données

Resume : Les donnees geographiques sont cruciales pour une localisation precise et le geo-referencement de tout ce qui peut etre utile sur notre terre. A ce moment ou le Web de donnees promeut l’idee d’avoir de plus en plus de donnees liees entre elles, il apparait crucial de modeliser les donnees geographiques de maniere efficace, en faisant usage des standards et vocabulaires existants afin de decrire de facon precise les formes geometriques. Jusqu’ici, les initiatives existantes n’utilisent pas toujours la meme approche pour la modelisation des objets geometriques. Dans cet article, nous passons en revue les approches les plus utilisees tant dans les initiatives de Linked Open Data (LOD) que dans la communaute des Systemes d’Information Geographique (SIG). L’interet etant de contribuer aux efforts actuels de representer les objets geographiques qui possedent des attributs lies a l’adresse, localisation ou emplacement. Nous proposons des alignements avec l’ontologie GeOnto, decrivant particulierement la taxonomie dans le contexte francais, et dont la publication prochaine selon les principes du Linked Data favorisera l’interoperabilite avec les vocabulaires existants (DBpedia, GeoNames, Schema.org, LinkedGeoData, Foursquare, etc.). Nous proposons enfin quelques recommandations des aspects a prendre en compte dans la publication des objets geometriques sur le web de donnees. Mots-cles : Ontologies, geographie, geometrie, Web de donnees, modelisation
Functional cerebral asymmetry and sexual orientation in men and women.

Functional cerebral asymmetry was assessed in 32 gay men and 32 heterosexual men and in 30 lesbians and 30 heterosexual women with a linguistic dichotic listening test. All groups showed the typical greater right-ear accuracy and, by inference, left-hemisphere representation for language functions. As shown repeatedly in previous studies (e.g., M. P. Bryden, 1982), among heterosexuals, consistent-right-handers showed greater perceptual asymmetry than did non consistent-right-handers. In contrast, gay men and lesbians did not show an association between hand preference and magnitude of perceptual asymmetry. The results indicate different patterns of functional cerebral asymmetry in gay men and lesbians compared with heterosexual people and specifically, less association between motoric and linguistic components of cerebral asymmetry. This suggestion of atypical patterns of functional asymmetries is consistent with previous results of an increased prevalence of left-hand preference among gay men and lesbians compared with the heterosexual population (C. M. McCormick, S. F. Witelson, & E. Kingstone, 1990; C. M. McCormick & S. F. Witelson, 1991). The finding of an association between aspects of functional asymmetry, a neurological characteristics likely present from birth, and sexual orientation suggests that a neurobiological factor is involved in the origins of sexual orientation.
Congenital panfollicular nevus: report of a new entity

The various forms of non‐melanocytic nevi (hamartomas) are usually encountered in pediatric patients, and nevus sebaceous of Jadassohn is the most common to have undifferentiated pilosebaceous units. We report a unique congenital follicular nevus that fails to meet the criteria of any previously described follicular neoplasm, despite the plethora of alternatives. Clinically considered a syringocystadenoma papilliferum, the excised lesion contained multiple dermal nodules that exhibited nearly all stages of follicular differentiation. The periodicity of the follicular proliferations was akin to normal terminal hair, and a prominent perifollicular sheath surrounded each. This benign lesion of abortive hair follicles was unassociated with any established genodermatous syndrome or other adnexal neoplasm.
Prognostic significance of Daxx NCR (Nuclear/Cytoplasmic Ratio) in gastric cancer

In addition to regulating apoptosis via its interaction with the death domain of Fas receptor, death domain associated protein 6 (Daxx) is also known to be involved in transcriptional regulation, suggesting that the function of Daxx depends on its subcellular localization. In this study, we aimed to explore Daxx subcellular localization in gastric cancer (GC) cells and correlate the findings with clinical data in GC patients. Seventy pairs of tissue samples (GC and adjacent normal tissue) were analyzed immunohistochemically for Daxx expression and localization (nuclear and cytoplasmic). The Daxx Nuclear/Cytoplasmic ratio (Daxx NCR) values in tissue microarray data with 522 tumor samples were further analyzed. The defined Prior cohort (n = 277, treatment between 2006 and 2009) and Recent cohort (n = 245, treatment between 2010 and 2011) were then used to examine the relationship between Daxx NCR and clinical data. The Daxx NCR was found to be clinically informative and significantly higher in GC tissue. Using Daxx NCR (risk ratio = 2.0), both the Prior and Recent cohorts were divided into high‐ and low‐risk groups. Relative to the low‐risk group, the high‐risk patients had a shorter disease free survival (DFS) and overall survival (OS) in both cohorts. Importantly, postoperative chemotherapy was found having differential effect on high‐ and low‐risk patients. Such chemotherapy brought no survival benefit, (and could potentially be detrimental,) to high‐risk patients after surgery. Daxx NCR could be used as a prognosis factor in GC patients, and may help select the appropriate population to benefit from chemotherapy after surgery.
Effects of exercise and CO2 inhalation on intersubject variability in ventilatory and heart rate responses to progressive hypoxia.

Although the ventilatory and heart rate responses to hypoxia are known to vary widely among subjects, it is not known how exercise or hypercapnia influence the intersubject variability of these responses. If the intersubject variability increases under such conditions, the inherent response of individuals will have more impact on ventilation and heart rate under a variety of hypoxic conditions during exercise or with hypercapnia than at rest or with normocapnia. Seventeen healthy male volunteers underwent tests to measure ventilatory response to isocapnic progressive hypoxia three times respectively: at rest; during CO2 inhalation (end-tidal carbon dioxide tension (PET,CO2) raised by 5 torr from the baseline level); and during mild exercise with a cycle ergometer (12.5 W) in a supine position. The mean (SEM) value of hypoxic ventilatory response (HVR) (delta minute ventilation (V'E)/delta arterial oxygen saturation (Sa,O2) was significantly increased both in the exercise and hypercapnic runs compared with that in the control run (0.45 +/- 0.12, 0.34 +/- 0.08, respectively, vs 0.12 +/- 0.02 L.min-1/% fall), although the respiratory pattern was different under the two loaded conditions. The intersubject variation in HVR was also significantly increased during the two loaded conditions compared with the control, although a significant correlation remained between the control value and that obtained during either loaded condition (r = 0.66 and r = 0.60, respectively). The heart rate (HR) response evaluated by the slope factor (delta HR/delta Sa,O2) was not significantly different either in the mean value or in the intersubject variability among the three experimental conditions. In conclusion, exercise or CO2 inhalation not only increase the slope value of HVR but also amplify the intersubject variability of the response. In contrast, the HR response to hypoxia evaluated as a slope factor does not change with exercise or CO2 inhalation.
Más allá de Internet: La Realidad Aumentada en la clase de E/LE

La Realidad Aumentada (en adelante RA) puede suponer en la docencia un importante paso para la comprension de terminos y conceptos por parte del alumno. Se proyecta como un gran salto cualitativo en la ensenanza, ya que permitira transformar la manera en que los estudiantes perciben la realidad fisica. Gracias a la RA los aprendientes de espanol podran tomar el control de su propio aprendizaje, siempre correctamente tutelados. La tecnologia ya esta disponible, es mayoritariamente gratuita y no presenta complejidad en su utilizacion. La generalizacion en el uso de telefonos inteligentes por parte de la sociedad facilita, ademas, que pueda ser llevada la practica de manera inmediata. Eso si, para ello los docentes deben conocer esta herramienta y las posibilidades que brinda en el terreno de la ensenanza.
Structure‐activity studies on endothelin (16–21), the C‐terminal hexapeptide of the endothelins, in the guinea‐pig bronchus

1 We describe the results of a structure‐activity study in which the C‐terminal hexapeptide of the endothelins, endothelin (16–21), is compared with shorter fragments; hexapeptides bearing amino‐acid substitutions and the corresponding C‐terminal fragments of sarafotoxins. The guinea‐pig bronchus was used in this study since it is the most sensitive preparation for endothelin (16–21) thus far developed. 2 The biological results obtained with endothelin (16–21) and analogues demonstrate that the contractile activity of the C‐terminal hexapeptide of endothelin on the guinea‐pig bronchus depends on quite close structural requirements, strongly suggestive of a receptor interaction. The following features appear to be essential for the biological activity: (a) the C‐terminal free carboxylic function; (b) the L‐configuration of Trp‐21; (c) the β‐carboxylic function of Asp‐18; (d) the presence of Leu‐17 and (e) the imidazole moiety of His‐16. 3 The hexapeptide corresponding to the C‐terminal portion of sarafotoxin, sarafotoxin (16–21), was devoid of biological activity. This behaviour might be related to the proposed existence of more than one receptor for the endothelin/sarafotoxin family in the guinea‐pig bronchus.
Monitoring the Response to Primary Medical Therapy for Breast Cancer Using Three-Dimensional Time-Resolved Optical Mammography

Primary medical therapy is used to reduce tumour size prior to surgery in women with locally advanced breast cancer. Optical tomography is a functional imaging technique using near-infrared light to produce three-dimensional breast images of tissue oxygen saturation and haemoglobin concentration. Its advantages include the ability to display quantitative physiological information, and to allow repeated scans without the hazards associated with exposure to ionising radiation. There is a need for a non-invasive functional imaging tool to evaluate response to treatment, so that non-responders can be given the opportunity to change their treatment regimen. Here, we evaluate the use of optical tomography for this purpose. Four women with newly diagnosed breast cancer who were about to undergo primary medical therapy gave informed and voluntary consent to take part in the study. Changes in physiological and optical properties within the tumour were evaluated during the course of neoadjuvant chemotherapy. Optical imaging was performed prior to treatment, after the first cycle of chemotherapy, halfway through, and on completion of chemotherapy. Images of light absorption and scatter at two wavelengths were produced, from which images of total haemoglobin concentration and oxygen saturation were derived. All patients that showed a good or complete response to treatment on MRI showed a corresponding recovery in the haemoglobin concentration images. Changes in mean tumour total haemoglobin concentration could be seen four weeks into treatment. The tumour oxygen saturation was low compared to background in three out of four patients, and also showed a return to baseline over treatment. Optical imaging of the breast is feasible during primary medical therapy and can be used to assess response to treatment over six months.
Simulation aided optimisation of manufacturing processes in university education

Simulation methods become more and more important in practical applications of scheduling, analysis and optimisation of manufacturing processes. One consequence is that the event discrete simulation systems and their application become part of the fundamentals of engineering education, even if the students should not become specialists in simulation methods. In our paper we show how the simulation of manufacturing processes can be used to make the theory clearer. The simulation models are simple but the need further development towards more complex and more practical models becomes apparent. This paper is also a field report about experiences with the simcron MODELLER in education.
Serine 2481-autophosphorylation of mammalian target of rapamycin (mTOR) couples with chromosome condensation and segregation during mitosis: confocal microscopy characterization and immunohistochemical validation of PP-mTOR(Ser2481) as a novel high-contrast mitosis marker in breast cancer core biops

The prognostic abilities of breast cancer gene expression signatures are due mostly to the detection of proliferation activity. One of the strongest, yet simple and well-reproducible proliferation-associated prognostic factors is the mitotic activity index (MAI). However: a) counting mitotic figures is regarded by many histopathologists as cumbersome and time-consuming, and b) most available immunohistochemical markers are much weaker predictors than the MAI. We have investigated the spatio-temporal sub-cellular distribution of the Serine 2481-autophosphorylated form of mTOR (PP-mTOR(Ser2481)) during the G(1)/S-to-M-phase transition both in cultured cancer cells and in cancer tissue specimens. Using a high-resolution, automated confocal high-content imaging system, we observed that mitotic cells notably accumulated a distinct pattern of nuclear and cytoplasmic immunolabelings of PP-mTOR(Ser2481). Parallel experiments examining site-specific phosphorylation (i.e., Serine 10 and Serine 28) of the G(2)/M marker Histone H3 (PP-H3) revealed that PP-H3(Ser10/Ser28) staining efficiently detected mitotic cells from prophase until the beginning of anaphase, but not during late anaphase, telophase and cytokinesis. PP-mTOR(Ser2481) staining associated near and between separating chromosomes not only during early mitotic stages but also to the midzone and to midbody at ana/telophase through cytokinesis. We then evaluated the usefulness of PP-mTOR(Ser2481) immunostaining for improving the efficiency of mitotic counting using. Anti-PP-mTOR(Ser2481)-labeled mitotic figures (MFs) were easily seen and permitted a quick identification of mitotic hotspots in formalin-fixed cancer tissues, even at low magnification. Importantly, average mitotic counts were significantly higher when using PP-mTOR(Ser2481) staining than with the hematoxylin and eosin (H&E) protocol in breast cancer core biopsies. Mitotic count based on PP-mTOR(Ser2481) immunostaining increased tumor grade by one grade in 2 of 9 breast carcinomas. These findings warrant forthcoming studies to confirm both the accuracy and the prognostic value of PP-mTOR(Ser2481) as a novel high-contrast immunohistochemical mitosis marker in larger populations of human breast carcinomas.
What are they trying to do?: An analysis of Action Identities in using electronic documentation in an EHR

Documentation processes have changed substantially with EHR adoption. User satisfaction studies have focused on usability or cognitive analysis perspectives. Few studies have provided useful information to developers to improve designs. The purpose of this study is to report a 3-pronged approach to deepen understanding of the documentation process, with the intent to provide useful information for future design. This study was conducted in two phases, beginning with cognitive task interviews and observations, followed by post-observation interviews. Twenty-five constructs were identified across the phases, and we observed several patterns of note writing. Participants provided useful information to potentially inform future design. Our study illustrates how electronic documentation serves many clinical processes and is at the core of the medical record. Providers need multiple kinds of notes and ways to display notes. In order to meet provider goals, we must completely re-think the way electronic documentation is composed and displayed.
Implementation of KL Algorithm for Partitioning using Perl

: This paper presents the implementation of KL algorithm for circuit partitioning using PERL. Circuit partitioning is NP hard problem. To solve the circuit partitioning problem, heuristic iterative algorithm is used. The algorithm treats the circuit as a graph, logic gates as nodes and interconnecting nets as edges. It randomly generates the initial partition of the circuit. The text file is used as an input which contains list of nodes and adjacency matrix of edges. The complete algorithm is implemented using arrays and associative arrays in PERL. Associative arrays are used to store the initial partition, improvement values, gain values and final partition. Nodes are stored as keys of associative arrays. The output file is generated which contains final partitions. This process helps to reduce the computation time of this iterative algorithm.
Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism

In many cells and specially in muscle, mitochondria form elongated filaments or a branched reticulum. We show that Mfn2 (mitofusin 2), a mitochondrial membrane protein that participates in mitochondrial fusion in mammalian cells, is induced during myogenesis and contributes to the maintenance and operation of the mitochondrial network. Repression of Mfn2 caused morphological and functional fragmentation of the mitochondrial network into independent clusters. Concomitantly, repression of Mfn2 reduced glucose oxidation, mitochondrial membrane potential, cell respiration, and mitochondrial proton leak. We also show that the Mfn2-dependent mechanism of mitochondrial control is disturbed in obesity by reduced Mfn2 expression. In all, our data indicate that Mfn2 expression is crucial in mitochondrial metabolism through the maintenance of the mitochondrial network architecture, and reduced Mfn2 expression may explain some of the metabolic alterations associated with obesity.
NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN)

ABSTRACT Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease that occurs in the setting of insulin resistance and increased adiposity. It has rapidly evolved into the most common liver disease seen in the pediatric population and is a management challenge for general pediatric practitioners, subspecialists, and for health systems. In this guideline, the expert committee on NAFLD reviewed and summarized the available literature, formulating recommendations to guide screening and clinical care of children with NAFLD.
Efeitos da similaridade ortográfica das pseudopalavras no acesso lexical

O presente estudo investigou o efeito que a similaridade ortografica de um estimulo tem no tempo de reacao e na precisao dos participantes em uma tarefa de decisao lexical. Para tanto, contou com pseudopalavras que correspondiam a uma manipulacao fatorial de duas medidas de similaridade ortografica: N – o numero de vizinhos ortograficos formados pela substituicao de uma letra do estimulo-alvo (p. ex.: ‘navela’ e ‘novela’) e TLN – o numero de vizinhos ortograficos formados pela inversao na ordem de duas letras do estimulo-alvo (p. ex.: ‘ânuglo’ e ‘ângulo’). Participaram da pesquisa 20 estudantes de um curso de pos-graduacao em Psicologia, selecionados por amostragem nao probabilistica de conveniencia. Utilizou-se um delineamento de medidas repetidas do tipo 2 x 2, correspondendo a uma manipulacao fatorial de N e TLN. Observou-se uma interacao entre TLN e N, na qual TLN apresentou um efeito inibidor apenas para as pseudopalavras que nao tinham vizinhos ortograficos formados pela substituicao de uma letra. Argumentou-se que o efeito de TLN traz desafios para os esquemas representacionais dos modelos atuais de leitura habil.