Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical, Biochemical and Genetic Variables Associated With Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders Using Second-Generation Antipsychotics: A Systematic Review

Background: Individuals with severe mental illness experience increased morbidity and mortality compared to the general population. Adverse effects of antipsychotics, including weight gain, may contribute to the development of metabolic syndrome (MetS), which is associated with increased risks of all-cause and cardiovascular disease mortality. We aim to provide a comprehensive overview of clinical, biochemical and genetic factors associated with MetS among patients with schizophrenia spectrum disorders using second-generation antipsychotics (SGA). Methods: A literature search was performed in Pubmed and Embase to identify all cohort studies, cross-sectional studies and clinical trials investigating associations with MetS in patients with schizophrenia spectrum disorders using SGAs. We extracted and enumerated clinical, biochemical and genetic factors reported to be associated with MetS. We defined factors associated with MetS as factors being reported as associated with MetS in two or more studies. Results: 58 studies were included in this review (n = 12,123). In total, 62 factors were found to be associated with increased risk of MetS. Thirty one out of 58 studies investigated factors that were reported as associated with MetS in two or more studies. With regard to clinical factors, we found gender, higher age, concomitant use of mood stabilizers, higher baseline and current BMI, earlier SGA exposure, higher dose, longer duration of treatment, psychosis and tobacco smoking to be significantly associated with MetS. Furthermore, the biochemical factors hypo-adiponectinemia, elevated levels of C-reactive protein (CRP) and higher white blood cell (WBC) count were identified as factors associated with MetS. Among pharmacogenetic factors, the rs1414334 C-allele of the HTR2C-gene was associated with MetS in patients using SGA. Conclusion: In this systematic review investigating clinical, biochemical and genetic factors associated with MetS in patients using SGAs we found that higher age, higher baseline BMI, higher current BMI and male as well as female gender were positively associated with MetS across all antipsychotics. This study may set the stage for the application of clinical, biochemical and genetic factors to predict the risk of developing MetS in patients using SGAs. Future research is needed to determine which patients using SGAs are at risk to develop MetS in clinical practice.
A Link Between Communities of Protective Endosymbionts and Parasitoids of the Pea Aphid Revealed in Unmanipulated Agricultural Systems

In the last decade, the influence of microbial symbionts on ecological and physiological traits of their hosts has been increasingly recognized. However, most of these effects have been revealed under laboratory conditions, which oversimplifies the complexity of the factors involved in the dynamics of symbiotic associations in nature. The pea aphid, Acyrthosiphon pisum, forms a complex of plant-adapted biotypes, which strongly differ in the prevalence of their facultative endosymbionts. Some of the facultative endosymbionts of A. pisum have been shown to confer protection against natural enemies, among which Hamiltonella defensa is known to protect its host from parasitoid wasps. Here, we tested under natural conditions whether the endosymbiont communities of different A. pisum biotypes had a protective effect on their hosts and whether endosymbiotic associations and parasitoid communities associated with the pea aphid complex were linked. A space-time monitoring of symbiotic associations, parasitoid pressure and parasitoid communities was carried out in three A. pisum biotypes respectively specialized on Medicago sativa (alfalfa), Pisum sativum (pea), and Trifolium sp. (clover) throughout the whole cropping season. While symbiotic associations, and to a lesser extent, parasitoid communities were stable over time and structured mainly by the A. pisum biotypes, the parasitoid pressure strongly varied during the season and differed among the three biotypes. This suggests a limited influence of parasitoid pressure on the dynamics of facultative endosymbionts at a seasonal scale. However, we found a positive correlation between the α and β diversities of the endosymbiont and parasitoid communities, indicating interactions between these two guilds. Also, we revealed a negative correlation between the prevalence of H. defensa and Fukatsuia symbiotica in co-infection and the intensity of parasitoid pressure in the alfalfa biotype, confirming in field conditions the protective effect of this symbiotic combination.
The Paleoclimate Significance of the δ13C Composition of Individual Hydrocarbon Compounds in the Maoming Oil Shales, China

Maoming oil shales are typical low-altitude lacustrine sediments that were deposited during the late Paleogene. The hydrocarbon composition and compound-specific stable carbon isotopic composition (δ13C) of organic matter in the profile samples of the oil shales have been analyzed. The results show that algae and aquatic plants are major parent sources of the organic matter in the oil shales associated with a small portion of terrestrial higher plant input. The δ13C composition of the bulk organic matter and the n-alkanes varies greatly on the profile from −26.9 to −15.8‰ and −31.7 to −16.2‰, respectively. While a good positive correlation among the δ13C composition of individual n-alkanes implies that these n-alkanes were originated from the similar source input. The δ13C composition of n-alkanes on the profile displays a positive excursion trend from the bottom to the top, and this excursion was likely related to the general decreasing trend of the partial pressure of atmospheric CO2 (pCO2) during the late Paleogene. The δ13C composition of the C30-4-methyl steranes ranges from −11.9 to −6.3‰, which is suggestive of Dinoflagellates-related source input. Coincidently, the high abundance C33-botryococcanes were detected in the samples on the top section of the profile and display an extremely positive carbon isotopic composition of −4.5 to −8.4‰, suggesting that the lower partial pressure of atmospheric CO2 had triggered a bicarbonate consumption mechanism for Botryococcus braunii B. Therefore, the δ13C composition of n-alkanes and C33-botryococcanes and their profile variation suggest that a general declining process associated with fluctuation in the partial pressure of atmospheric CO2 is likely the major reason for the rapid climatic changes toward the end of the late Paleogene.
Antecedents and Relative Importance of Student Motivation for Science and Mathematics Achievement in TIMSS

Although motivation has been shown to have substantial influence on learning, the relative significance of Students’ motivational characteristics, compared to other school-related factors, for student learning and performance is still unclear. Furthermore, knowledge about the relative importance of different situational variables for predicting these motivational characteristics is crucial for educational decisions about how to enhance student motivation. This study examined (1) the relative importance of motivational characteristics derived from five different theories on motivation and epistemic beliefs, compared to almost 300 situational factors, for predicting student performance on the TIMSS 2011 achievement tests in science and mathematics, and (2) how student motivational characteristics can be predicted by the background variables in the TIMSS 2011 questionnaires and an additional questionnaire about motivation accompanying TIMSS in Sweden. Up to 52% of the variation in student performance could be predicted by models containing all background variables, and student motivational characteristics were among the most important variables in the model. Models that comprised only student motivational characteristics from several motivation theories predicted up to 27% of student performance on the achievement test, while models using only single motivational characteristics predicted, on average, 7%. Results emphasize teachers’ importance for student motivation. Five teacher features were consistently among the most important variables in predicting Students’ motivational characteristics. These five variables predicted as much of the variation in important student motivational characteristics as the remaining 300 situational variables together.
Surface energy of spinel

The contributions of the Coulomb electrostatic interaction and the Born‐Mayer repulsive interaction to the surface energy MgAl2O4 are calculated. These results are compared with the surface‐energy values calculated from elastic constants. The results show that surfaces parallel to {111} planes are of lowest energy for MgAl2O4 spinel as well as some spinel ferrites. Except for qualitative evidence, most of these predictions await experimental verification, including the predictions of the composition of freshly cleaved spinel surfaces.
Endothelial Cell Behavior Is Determined by Receptor Clustering Induced by Thrombospondin-1

The thrombospondins (TSPs) are a family of multimeric extracellular matrix proteins that dynamically regulate cellular behavior and response to stimuli. In so doing, the TSPs directly and indirectly affect biological processes such as embryonic development, wound healing, immune response, angiogenesis, and cancer progression. Many of the direct effects of Thrombospondin 1 (TSP-1) result from the engagement of a wide range of cell surface receptors including syndecans, low density lipoprotein receptor-related protein 1 (LRP1), CD36, integrins, and CD47. Different or even opposing outcomes of TSP-1 actions in certain pathologic contexts may occur, depending on the structural/functional domain involved. To expedite response to external stimuli, these receptors, along with vascular endothelial growth factor receptor 2 (VEGFR2) and Src family kinases, are present in specific membrane microdomains, such as lipid rafts or tetraspanin-enriched microdomains. The molecular organization of these membrane microdomains and their constituents is modulated by TSP-1. In this review, we will describe how the presence of TSP-1 at the plasma membrane affects endothelial cell signal transduction and angiogenesis.
Lysosome (Dys)function in Atherosclerosis—A Big Weight on the Shoulders of a Small Organelle

Atherosclerosis is a progressive insidious chronic disease that underlies most of the cardiovascular pathologies, including myocardial infarction and ischemic stroke. The malfunctioning of the lysosomal compartment has a central role in the etiology and pathogenesis of atherosclerosis. Lysosomes are the degradative organelles of mammalian cells and process endogenous and exogenous substrates in a very efficient manner. Dysfunction of these organelles and consequent inefficient degradation of modified low-density lipoproteins (LDL) and apoptotic cells in atherosclerotic lesions have, therefore, numerous deleterious consequences for cellular homeostasis and disease progression. Lysosome dysfunction has been mostly studied in the context of the inherited lysosomal storage disorders (LSDs). However, over the last years it has become increasingly evident that the consequences of this phenomenon are more far-reaching, also influencing the progression of multiple acquired human pathologies, such as neurodegenerative diseases, cancer, and cardiovascular diseases (CVDs). During the formation of atherosclerotic plaques, the lysosomal compartment of the various cells constituting the arterial wall is under severe stress, due to the tremendous amounts of lipoproteins being processed by these cells. The uncontrolled uptake of modified lipoproteins by arterial phagocytic cells, namely macrophages and vascular smooth muscle cells (VSMCs), is the initial step that triggers the pathogenic cascade culminating in the formation of atheroma. These cells become pathogenic “foam cells,” which are characterized by dysfunctional lipid-laden lysosomes. Here, we summarize the current knowledge regarding the origin and impact of the malfunctioning of the lysosomal compartment in plaque cells. We further analyze how the field of LSD research may contribute with some insights to the study of CVDs, particularly how therapeutic approaches that target the lysosomes in LSDs could be applied to hamper atherosclerosis progression and associated mortality.
The Relations Among Types of Parentification, School Achievement, and Quality of Life in Early Adolescence: An Exploratory Study

Children who experience parentification may have trouble performing developmental tasks due to being overwhelmed by their family caregiving roles and responsibilities. Past studies have found that parentification is negatively associated with academic achievement. However, most of these studies are limited in that they are retrospective and examine the association but not the mechanisms shaping them. The aim of the study was to explore to what extent diverse types of parentification relate to academic achievement and to what extent these relations are mediated by self-reported quality of life among adolescents. The study sample was composed of Polish early adolescents (N = 191; age: M = 14.61; SD = 1.26). Types of parentification were measured with the Parentification Questionnaire for Youth, and quality of life was assessed with KidScreen27. School achievement was measured based on mean semester grade. We explored the associations among study variables and performed six mediation models in the planned analyses. Overall, bivariate relations were significant in a theoretically expected way, although the effect sizes for these associations were rather small. In the mediation analyses, the results showed that four of the six models were not significant. Different from previous studies, instrumental parentification was positively related to school achievement. Additionally, this positive association was mediated by adolescents’ general quality of life. Taken together, the findings were similar and different from the empirical literature base on types of parentification and select outcomes.
Different Pasts for Different Political Folk: Political Orientation Predicts Collective Nostalgia Content

Collective nostalgia is a bittersweet emotion that reflects sentimental longing for valued aspects of the past of one’s group. Given that conservatism is typically associated with a general desire to preserve the societal status quo or return society to its traditional way of being, nostalgia has been theorized to be characteristic of those on the political right (i.e., conservatives). In the current work, we proposed and tested the hypothesis that collective nostalgia is experienced by both conservatives and liberals, but the content of their nostalgizing differs. Across three studies in three socio-political contexts—United States (Study 1, MTurk, N = 352), Canada (Study 2, student sample, N = 154), and England (Study 3, online panel, N = 2,345)—we found that both conservatives and liberals experienced collective nostalgia for a more homogenous and open society. However, conservatives experienced more homogeneity-focused collective nostalgia, whereas liberals experienced more openness-focused collective nostalgia. Replicating previous findings, homogeneity-focused nostalgia emerged as a positive, whereas openness-focused nostalgia emerged as a negative, predictor of intergroup attitudes. The results have both theoretical and practical significance for understanding political attitudes and behaviors. To the point, variance in the conservative and liberal political agendas is, in part, a function of a difference in their respective predisposition to nostalgize about and thus desire the return of a particular aspect of the in-group’s past.
Assessing the impact of widespread respirator use in curtailing COVID-19 transmission in the United States

Dynamic models are used to assess the impact of three types of face masks - cloth masks, surgical/procedure masks and respirators - in controlling the COVID-19 pandemic in the United States. We showed that the pandemic would have failed to establish in the US if a nationwide mask mandate, based on using respirators with moderately-high compliance, had been implemented during the first two months of the pandemic. The other mask types would fail to prevent the pandemic from becoming established. When mask usage compliance is low to moderate, respirators are far more effective in reducing disease burden. Using data from the third wave, we showed that the epidemic could be eliminated in the US if at least 40% of the population consistently wore respirators in public. Surgical masks can also lead to elimination, but requires compliance of at least 55%. Daily COVID-19 mortality could be eliminated in the US by June or July 2021 if 95% of the population opted for either respirators or surgical masks from the beginning of the third wave. We showed that the prospect of effective control or elimination of the pandemic using mask-based strategy is greatly enhanced if combined with other nonpharmaceutical interventions that significantly reduce the baseline community transmission. This study further emphasizes the role of human behavior towards masking on COVID-19 burden, and highlights the urgent need to maintain a healthy stockpile of highly-effective respiratory protection, particularly respirators, to be made available to the general public in times of future outbreaks or pandemics of respiratory diseases that inflict severe public health and socio-economic burden on the population.
Unsupervised classification methods in food sciences: discussion and outlook

This paper reviews three unsupervised multivariate classification methods: principal component analysis, principal component similarity analysis and heuristic cluster analysis. The theoretical basis of each method is presented in brief, and assumptions inherent to the methods are highlighted. A literature review shows that these methods have sometimes been used inappropriately or without referencing all essential parameters. The paper also brings to the attention of the reader a relatively unknown method: probabilistic or model-based cluster analysis. The goal of this method is to uncover the true classification of objects rather than a convenient classification provided by the other methods. For this reason it is felt that model-based cluster analysis will have broad application in the future. Copyright © 2008 Society of Chemical Industry
Days Spent at Home near the End of Life in Japanese Elderly Patients with Lung Cancer: Post hoc Analysis of A Prospective Study

Objective: Days spent at home (DASH) near the end of life is considered an important patient-centered goal and outcome because many patients want to stay at home toward the end of life. This study aimed to estimate the individual DASH near the end of life and identify its early predictors, including muscle mass and physical function, among elderly patients with advanced non-small-cell lung cancer (NSCLC). Methods: We conducted a post hoc analysis of the prospective observational study (UMIN000009768) that recruited patients aged ≥ 70 years who were scheduled to undergo first-line chemotherapy because of advanced NSCLC. We measured the muscle mass by bioelectrical impedance analysis at baseline. DASH was calculated as 30 days minus the number of days spent in hospitals, palliative care facilities, or nursing homes during the last 30 days of life. We performed linear regression analyses to evaluate the predictors of DASH. Results: Altogether, 16 women and 28 men with a median overall survival of 15.5 months (range: 2.9–58.9) were included. The median DASH in the last 30 days of life was 8 days (range: 0–30, interquartile range: 0–23). Men had longer DASH than women by 7.3 days. Patients who had good trunk muscle mass index and hand-grip strength had significantly longer DASH than those who did not (4.7 days per kg/m2 increase [P = 0.017] and 0.4 days per kg increase [P = 0.032], respectively). Conclusions: Most elderly patients with advanced NSCLC had a limited DASH near the end of life. The risk factors for reduced DASH were women, reduced muscle mass, and poor physical function at the time of diagnosis of advanced NSCLC. Our findings would encourage early discussions about end-of-life care for patients with advanced cancers with risk factors for short DASH at the time of diagnosis, and thus, improve the quality of end-of-life care.
The role of hyperbaric oxygen therapy in inflammatory bowel disease: a narrative review

Inflammatory bowel disease is a group of chronic recurrent diseases in the digestive tract, including ulcerative colitis and Crohn’s disease. Over the past few decades, the treatment of IBD has made great progress but there is still a lot of room for improvement. Hyperbaric oxygen therapy (HBOT) was defined as the therapeutic effect of inhaling 100% oxygen higher than one atmosphere and reported to be used in stroke, decompression sickness and wound healing. Since several authors reported the role of HBOT as an adjunct to conventional medical treatment in patients with refractory IBD, the relevant research has shown an increasing trend in recent years. Clinical and experimental studies have revealed that HBOT may exert its therapeutic effect by inhibiting inflammation and strengthening the antioxidant system, promoting the differentiation of colonic stem cells and recruiting cells involved in repair. The purpose of this review is to summarize the past clinical and experimental studies and to understand the impact of HBOT in the treatment of IBD more deeply. In addition, we also hope to provide some ideas for future clinical and research work.
Self-diffusion in molten sodium chloride: a test of the applicability of the Nernst—Einstein equation

Self-diffusion coefficients of sodium and chlorine in molten sodium chloride have been determined by the capillary method with the aid of 22Na and 36Cl radio-tracers. The results can be represented by the expressions DNa = 8x 10-4 exp (-4000/RT) and DCl = 33 x 10-4 exp (-8500/.RT). These values, when inserted in the Nernst-Einstein equation (A = (F2/RT) (D+ D-)), lead to a value of the equivalent conductance, A, which is about 40 % greater than that observed experimentally. The evidence that the diffusion coefficients of Na+ and Cl- are similar in magnitude and that the activation energies are much smaller than the heat of vaporization of liquid sodium chloride, support the conclusions, derived from other evidence, that the free volume in the molten salt consists largely of holes, analogous to vacant lattice sites. On the basis of this model, the discrepancy in the Nernst-Einstein relation can readily be interpreted in terms of two diffusion mechanisms, one being normal vacancy diffusion of single ions, and the other a process in which no net charge is displaced in a unit step. It is suggested that the latter is the Seitz-Dienes mechanism of consecutive jumps of cation and anion in coupled vacancies. The interpretation mentioned enables the individual mobilities of Na+ and Cl- ions to be determined, and hence their transport numbers can be calculated (tNa+= 0.71, tCl- = 0.29 at 935° C). The individual diffusion coefficients of the ions and of the coupled vacancies are in reasonable agreement with the Stokes-Einstein equation.