Miracle-dz/UniFAR-FTUs huggingface dataset:
Reliability and economic feasibility analysis of parallel unity power factor rectifier for wind turbine system

High power rated modern wind generators are demanding immaculate performance and greater reliability from the power electronics interface. In order to keep up to the challenges, advanced multilevel front-end rectifiers and parallel operation of rectifiers are researched. A higher number of semiconductor switches make reliability estimation and feasibility of converters a factor of industrial interrogation. This study focuses on the operation, reliability, and economic feasibility analysis of a parallel unity power factor rectifier (PUPFR). Each branch of the PUPFR has a three-phase diode rectifier and each phase of which is equipped with bidirectional switching blocks. Suitability of uninterrupted operation with lower down-time for instances of one branch failure, the system discussed provides higher feasibility, reliability, and options of modularity. The reliability is assessed by quantifying the failure rate of each component of the converter topology. The feasibility analysis of the PUPFR focuses on quantitative evaluation based on component pricing for initial cost, maintenance, power-loss calculation, operational cost, and capacity factor. The PUPFR is comparatively assessed with respect to its single branch topology, i.e. the unity power factor rectifier. Both the topologies are simulated in MATLAB®/Simulink and the system is experimentally validated on a 1 kW hardware setup.
One-step individual participant data network meta-analysis of time-to-event data

Network meta-analysis (NMA) combines direct and indirect evidence from trials to calculate and rank treatment effect estimates. While modelling approaches for continuous and binary outcomes are relatively well developed, less work has been done with time-to-event outcomes. Such outcomes have usually been analysed using Cox proportional hazard (PH) models, but in oncology, with longer follow-up of trials and time-dependent effects of targeted treatments, this may no longer be appropriate. Alongside this, NMA conducted in the Bayesian setting has been increasing in popularity. In this thesis I extend the work of Royston and Parmar to the NMA setting, showing that Royston-Parmar models, fitted in WinBUGS, provide a flexible, practical approach for Bayesian NMA with time-to-event data and can accommodate non-PH. Inconsistency in NMA occurs when the direct and indirect evidence are not in agreement with each other and can result in biased treatment effect estimates. It is therefore important that attempts are made to identify, understand and, where appropriate, adjust for inconsistency. In this thesis I consider four increasingly complex methods of assessing inconsistency in NMA, proposed (relatively) recently in the literature. Motivated by individual participant data (IPD) from 42 trials comparing radiotherapy, sequential and concomitant chemotherapy from 7531 people with lung cancer, I illustrate why one of these approaches may be misleading and propose an alternative approach. Stratified medicine aims to identify groups of patients most likely to respond to treatment. However, many trials are underpowered to detect clinically meaningful differences in subgroups. NMA models fitted with treatment-covariate interactions potentially have greater power to identify such differences. In the final part of this thesis I extend the one-step IPD NMA Royston-Parmar model to include treatment-covariate interactions, providing practical guidance on how to deal with missing covariate data and how to combine or separate within and across trial information.
The Cost Effectiveness of Screening for Early Stage Lung Cancer and the Testing and Treatment of Molecular Subgroups Among Non-small Cell Lung Cancer Patients in the Province of Ontario, Canada

Introduction: Lung cancer is the leading cause of cancer deaths in Canada, killing more people than breast, colorectal and prostate cancer combined. It is associated with age as it takes approximately 20 years for the disease to manifest itself. With the country’s aging population, the life and economic burden of lung cancer will only grow exponentially in the coming years. Objectives: In recent years, some progress has been made in improving the lives of those with lung cancer. This includes detecting it at an earlier stage and treating patients based on the genotype of their disease. Along with clinical efficacy, policy makers also want evidence of cost-effectiveness. The purpose of this dissertation is to estimate the cost-effectiveness of new interventions across the disease spectrum for non-small cell lung cancer patients by exploring three topics: The use of low-dose computed tomography (LDCT) for early disease detection, and the molecular subgroups testing and treatment of the oncogenes epidermal growth factor receptor (EGFR) mutation, and the anaplastic lymphoma kinase (ALK) fusion. iii Methods: The cost-effectiveness analyses were performed using state transition models and the perspective of the Ontario Ministry of Health. The LDCT analysis consisted of six years of annual screenings, the clinical data for which were derived from the University Health Network lung cancer screening trial. Molecular subgroups testing for EGFR would be done through direct sequencing of deoxyribonucleic acid and testing for ALK would be completed through immunohistochemistry staining and confirmed with fluorescence in situ hybridization. A willingness-to-pay threshold value of $50,000 per effectiveness was used in the analyses. Results: LDCT screening and the mutation testing and treatment of EGFR mutation positive lung cancer patients with gefitinib were economically attractive at $32,476 and $32,913 per QALY, respectively. The ICER for the ALK genomic testing and the use of crizotinib was $215,080 per QALY. The underlying key driver of cost-effectiveness was the cost of the drug, crizotinib, which would need to be decreased substantially (> 75%) for the ICER to fall below a $50,000 threshold. Conclusion: Novel interventions for the treatment of lung cancer may be cost-effective in the province of Ontario.
Kerja Sama Orang Tua Dan Guru Dalam Meningkatkan Prestasi Belajar Siswa Di MIN 07 Medan Kecamatan Medan Denai Medan Tahun Ajaran 2018/2019

Penelitian ini bertujuan untuk mengetahui: (1) Peran dan tanggung jawab orang tua dan guru, (2) Usaha-usaha kerja sama yang dilakukan orang tua siswa dan guru untuk meningkatkan prestasi belajar siswa di MIN 7 Kota Medan dan (3) Prestasi belajar siswa dengan diadakannya kerja sama antara orang tua siswa dan guru di MIN 7 Kota Medan. Penelitian ini merupakan penelitian Kualitatif dengan pendekatan Inkuiri Naturalistik (Naturalistic Inquiry) yaitu cara mengamati dan pengumpulan data dilakukan dalam latar/setting alamiah. Kemudian prosedur pengumpulan data melalui observasi, wawancara dan dokumentasi. Adapun hasil dari penelitian ini yaitu: (1) Peran dan tanggung jawab orang tua siswa dan guru di MIN 7 Kota Medan hampir sama, hanya saja peran dan tanggung jawab orang tua terhadap anak lebih menyeluruh dari pada guru sebab waktu anak lebih banyak dirumah dari pada di sekolah. (2) Usaha-usaha kerja sama yang dilakukan orang tua dan guru dalam meningkatkan prestasi belajar siswa di MIN 7 Kota Medan antara lain: membiasakan dan mengawasi anak dalam disiplin waktu belajar dan beribadah, selalu memberikan motivasi kepada anak, saling menjalin komunikasi yang baik, selalu memginformasikan perkembangan prestasi belajar anak kepada orang tua. (3) prestasi belajar siswa di MIN 7 Kota medan dengan diadakannya kerja sama antara orang tua siswa dan guru antara lain: a). Akademik: meningkatnya juara kelas yang diperoleh oleh siswa. b) Non-akademik: Mendapat Juara 1 Lomba tahfiz, Mendapat Juara 2 lomba MTQ, Juara 2 Lomba Pildacil, dan Mendapat Juara 1 Lomba P3K Dokter Kecil sekota Medan. Dengan adanya kerja sama antara orang tua siswa dan guru dalam pembelajaran maka akan berdampak baik terhadap peningkatan prestasi belajar anak.
Le parcours de soins MEDISIS : extension d'une expérimentation au sein d'un service de Soins de Suite et de Réadaptation

Le parcours de soins MEDISIS, centre sur la personne âgee poly-pathologique et poly-mediquee permet la securisation de la prise en charge medicamenteuse. Cette alliance therapeutique rend possible une emulation positive entre usagers et professionnels liberaux et hospitaliers pour la prise en charge des aines. L’objectif de ce travail est de realiser un etat des lieux des activites de pharmacie clinique au sein d’un service de soins de suite et de readaptation (SSR) afin d’etendre et d’harmoniser un parcours de soins securise au sein de SSR. Dans une perspective d’amelioration des pratiques, de l’efficience et de la qualite des soins, les points a ameliorer et les forces de l’existant sont analyses afin d’identifier les freins et les leviers de ce changement. Cela comprend egalement une compilation des activites de pharmacie clinique mise en œuvre au sein d’autres etablissements de meme typologie. En utilisant les outils de gestion de projet, l’harmonisation des pratiques s’etablit en respectant le cahier des charges MEDISIS. L’execution du projet est permise via le panel d’informations internes et la contribution de conceptions externes ; et l’elaboration d’outils de gestion de projet. Ainsi cette expertise permet de construire ce projet d’extension du parcours MEDISIS au sein d’un service de SSR. Cette demarche s’inscrit dans le cadre de l’amelioration de l’efficience et de la qualite des soins.
Focal epilepsy modulates vesicular positioning at cortical synapses

Abstract Neuronal networks’ hyperexcitability often results from an unbalance between excitatory and inhibitory neurotransmission; however, underlying synaptic alterations leading to this condition remains poorly understood. Here, we assess synaptic changes in the visual cortex of epileptic tetanus neurotoxin-injected mice. Using an ultrastructural measure of synaptic activity, we quantified functional differences at excitatory and inhibitory synapses. We found homeostatic changes in hyperexcitable networks, expressed as an early onset lengthening of active zones at inhibitory synapses followed by spatial reorganization of recycled vesicles at excitatory synapses. A proteomic analysis of synaptic content revealed an upregulation of Carboxypeptidase E (CPE) following Tetanus NeuroToxin (TeNT) injection. Remarkably, inhibition of CPE rapidly decreased network discharges in vivo. These analyses reveal a complex landscape of homeostatic changes affecting the epileptic synaptic release machinery, differentially at inhibitory and excitatory terminals. Our study unveil homeostatic presynaptic mechanisms which may impact release timing rather than synaptic strength.
The Marketing Mix Strategies of Patanjali Ayurveda

Patanjali began working with Patanjali Yogpeeth in Hardiwar, Uttarakhand. Patanjali yogpeeth is one of the largest yoga labs in the United States. Swami Ramdevji and Acharya Balkrishanaji is Patientjali Ayurveda Ltd. was established for treatment, research and development Ayurveda Yoga and Ayurveda produces pharmaceutical products. Patanjali Yogpeeth brought a coup in providing care and scientific research, and provides health services in the country with a combined approach to Yoga and Ayurveda. Free medical consultation infrastructure of Patanjali Yogpeeth has OPD, thousands of beds IPD, radiology, cardiovascular and pathology laboratories, a yoga research department, free yoga classes, a high-quality ayurvedic manufactured by Divya Pharmacy are drugs, cyber cafes, a huge hall, elderly apartments grand museums , a library and reading rooms with 11,000 square feet of sales channels for yoga and Ayurveda-related literature. Keywords: Small sector BPO, Large sector BPO, MNC, Corporate Culture, Mental Fatigue
Non-communicable Disease Prevention

contribu� ng to over 73% of all deaths annually. Each day NCDs cause more than 100,000 deaths, 80% of which occur in lowand middle-income countries. NCDs, however, are largely preventable, and a great deal of technical knowledge exists about how to prevent and manage them. Why, then, have we, as a global community, not been more successful at reducing this NCD burden? Does a universal problem not have a universal solu� on?
Peer assisted team-based learning in undergraduate dental education

The teaching system has seen an evolution in the same regard, from blackboard teaching to whiteboard teaching to smart board teaching. We now step foot into a new era of teaching with fresher minds to influence and shape. The present study mainly focuses on a rather new method of teaching called ‘Peer lead Team-based learning'. The method focuses mainly on the students and their active participation in the involved topic. To conduct the study, a batch of dental students were taught and were later assessed. The students thus specified are undergraduate students who were pursuing their 2nd year BDS at Saveetha Dental College and Hospitals. The total number of students that were considered was about thirty-three students. The students were of the age group of about 19-23 years. The subject that was imparted to these students in this method is Dental Materials which was initially perceived to be difficult by the 2nd year candidates. On completion of the period of study, the students were asked to take up an exam in the usual pattern prescribed by the University. The marks thus obtained were analysed with the previous tests and a questionnaire was filled by each student to obtain their perception towards this teaching system. On the analysis of the test scores, it was obtained that there was a significant difference in the average class score. There was a mean difference of about 8-11 marks on analysis of various tests. Thus this proves that the teaching system is immensely efficient. The responses from the questionnaire were assessed and it proved that the teaching system is welcomed by the student community. The teaching system is successful in a dental curriculum and under ideal conditions the system would be successful in other courses but has to be tested to confirm the same.
Neurally Adjusted Ventilatory Assist Is Associated with Greater Initial Extubation Success in Postoperative Congenital Heart Disease Patients when Compared to Conventional Mechanical Ventilation

Abstract Extubation failure is associated with considerable morbidity and mortality in postoperative patients with congenital heart disease (CHD). The study purpose was to investigate initial extubation success utilizing neurally adjusted ventilatory assist (NAVA) compared with pressure-regulated volume controlled, synchronized intermittent mandatory ventilation with pressure support (SIMV-PRVC + PS) for ventilatory weaning in patients who required prolonged mechanical ventilation (MV). Also, total days on MV, inotropes, sedation, analgesia, and pediatric intensive care unit (PICU) length of stay (LOS) between both groups were compared. This was a non-randomized pilot study utilizing historical controls (SIMV-PRVC + PS; n = 40) compared with a prospective study population (NAVA; n = 35) in a Level I PICU and was implemented to help future trial designs. All patients (n = 75) required prolonged MV ≥96 hours due to their complex postoperative course. Ventilator weaning initiation and management was standardized between both groups. Ninety-seven percent of the NAVA group was successfully extubated on the initial attempt, while 80% were in the SIMV-PRVC + PS group (p = 0.0317). Patients placed on NAVA were eight times more likely to have successful initial extubation (odds ratio [OR]: 8.50, 95% confidence interval [CI]: 1.01, 71.82). The NAVA group demonstrated a shorter median duration on MV (9.0 vs. 11.0 days, p = 0.032), PICU LOS (9.0 vs. 13.5 days, p < 0.0001), and shorter median duration of days on dopamine (8.0 vs. 11.0 days, p = 0.0022), milrinone (9.0 vs. 12.0 days, p = 0.0002), midazolam (8.0 vs. 12.0 days, p < 0.0001), and fentanyl (9.0 vs. 12.5 days, p < 0.0001) compared with the SIMV-PRVC + PS group. NAVA compared with SIMV-PRVC + PS was associated with a greater initial extubation success rate. NAVA should be considered as a mechanical ventilator weaning strategy in postoperative congenital heart disease (CHD) patients and warrants further investigation.
Linking biopsychosocial indicators with financial risk tolerance and satisfaction through macroeconomic literacy: A structural equation modeling approach

Abstract The purpose of the current research was to analyze the impact of biopsychosocial indicators on the financial risk tolerance (FRT) and financial satisfaction along with the mediating role of macroeconomic literacy in these associations. For this purpose, three indicators names as “personality type, self-esteem, and sensation seeking” were used to check the impact of biopsychosocial indicators on FRT and financial satisfaction. The current study was conducted in China where the data was collected from retail investors through structured questionnaire. The purposive sampling technique was used to decide the sample from the population. The data were collected from 1134 retail investors and SPSS and AMOS were used to analyze the data by applying SEM. Findings of the current study revealed that the personality, self-esteem and sensation seeking have significant influences on FRT. It has been further found that the personality type and self-esteem have significant influences on the financial satisfaction. Results further confirmed the mediating role of macroeconomic literacy between self-esteem and FRT, personality type and FRT, self-esteem and financial satisfaction, and personality type and financial satisfaction. However, no significant mediating role of macroeconomic literacy was found between sensation seeking and FRT, and sensation seeking and financial satisfaction. The current study and findings will be of great importance for theory and practice regarding financial/investment decision making and FRT.
Surgical Approaches to Large Peripheral Nerve Sheets Tumors

Peripheral nerve sheath tumors (PNSTs) are not rare tumors. Its sound management is complete surgical excision. The aim of this study was to describe clinical presentation, accuracy of different investigations and ideal surgical approaches in relation to outcomes. The study is a prospective and included 26 surgically treated large PNSTs in 22 patients operated through different surgical approaches according to the site of the tumors. The fellow up period was 6 - 60 months. The mean age was 41.8 years, 9 were males and 13 were females. The common presentations were pain in 12 lesions, swelling in 8 lesions, neural deficits in 4 lesions and positive Tinel’s test in 2 lesions. These lesions were excised through 6 surgical approaches. Histopathological examination showed 20 benign and 6 malignant lesions. Five cases of malignant peripheral nerve sheet tumors (MPNSTs) had local recurrent, 4 cases had distant metastasis, 4 cases received chemotherapy and radiotherapy, and 4 cases were died in the postoperative fellow up period. It was concluded that surgical approaches to the PNSTs, depends on their locations. Adequate exposure with minimal dissection minimized the neurological deficit and decreased rate of local recurrence.
The status and challenges of clinical informatics development in South Africa

Clinical informatics has enormous potential to ensure healthcare quality in both developed and developing countries. This paper examines the status and challenges of clinical informatics in the South African health care sector, In a recent survey of major international research databases such as Scopus, it was observed that there is a gap in knowledge on clinical informatics particularly as related to the status and challenges in the country’s healthcare facilities . The current status and challenges of clinical informatics in South Africa has not been examined. The present study explores the the current status of clinical informatics in the South African healthcare system as well as the challenges facing the development of clinical informatics in South Africa. Through a literature review, the paper provides a conceptual background of clinical informatics, discusses the status and challenges of clinical informatics in South Africa. The last part of the paper discusses the implications of the reviewed literature through a PEST analysis. The paper provides invaluable information on clinical informatics in South Africa that can be used to inform and support further studies in this growing field. The paper is a contribution to discussions and debates on the development of social informatics. Keywords : clinical informatics, status, challenges, ICT4D, Social informatics, South Africa
Unraveling the influence of atmospheric evaporative demand on drought and its response to climate change

This review examines the role of the atmospheric evaporative demand (AED) in drought. AED is a complex concept and here we discuss possible AED definitions, the subsequent metrics to measure and estimate AED, and the different physical drivers that control it. The complex influence of AED on meteorological, environmental/agricultural and hydrological droughts is discussed, stressing the important spatial differences related to the climatological conditions. Likewise, AED influence on drought has implications regarding how different drought metrics consider AED in their attempts to quantify drought severity. Throughout the article, we assess literature findings with respect to: (a) recent drought trends and future projections; (b) the several uncertainties related to data availability; (c) the sensitivity of current drought metrics to AED; and (d) possible roles that both the radiative and physiological effects of increasing atmospheric CO2 concentrations may play as we progress into the future. All these issues preclude identifying a simple effect of the AED on drought severity. Rather it calls for different evaluations of drought impacts and trends under future climate scenarios, considering the complex feedbacks governing the climate system.
Mapping tasks to occupations using Philippine data

Treating occupations as bundles of tasks rather than discrete categories is the central idea upon which the "task approach" to labor market analysis is built. To apply the framework, this paper maps the 3,279 task characteristics of occupations using the International Standard Classification of Occupations 2008 (ISCO-08) to derive the task portfolios of 424 occupations listed under the Philippine Standard Occupational Classification (PSOC). These portfolios allow us to measure how intensive an occupation is in performing different tasks (e.g. non-routine analytical, non-routine interpersonal, non-routine manual, routine cognitive and routine manual). The main contribution of this paper is the task portfolios of the 424 occupations, which can be a starting point for further studies on the implications of automation, immigration, and international offshoring on employment and the returns to specific skills, not just in the Philippines but also for countries which base their local occupational codes to the ISCO.