Miracle-dz/UniFAR-FTUs huggingface dataset:
No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study

Introduction To assess the effect of tumor laterality to cardiac-related deaths of breast cancer in the current radiation practices using a large modern population-based study. Methods Women diagnosed with breast cancer from 2000 to 2008 were included using the current Surveillance, Epidemiology, and End Results database. The primary outcome of this study was the cardiac-related mortality. Multivariate analysis was performed using the Cox proportional hazards model to analyze the cardiac-related mortality including demographic, clinicopathologic, and treatment factors. Results We identified 168,761 breast cancer patients, including 85,006 (50.4%) patients with left-sided tumors and 83,755 (49.6%) patients with right-sided tumors. The median follow-up period was 8.8 years. The 10-year cardiac-related mortality was 2.3% and 2.3% in left- and right-sided tumors, respectively (P=0.685). The results indicated that patients with older age, non-Hispanic Black, receipt of mastectomy, and married status were the independent adverse factors for cardiac-related mortality. However, left-sided tumors were not associated to a higher risk of cardiac-related mortality than right-sided tumors following postoperative radiotherapy (right vs left, hazard ratios 1.025, 95% CI 0.856–1.099, P=0.484). The risk of cardiac-related mortality in the entire cohort was increased with the extension of follow-up time. However, there was still not significantly different between left- and right-sided tumors. Subgroup analysis also found no association between tumor laterality and cardiac-related mortality after postoperative radiotherapy based on various demographics and treatment factors. Conclusion With a median follow-up of 8.8 years, no significant differences were found in cardiac-related mortality between left- and right-sided tumors under current radiation practices of breast cancer patients.
The relevant and reliable language theory: developing a language measure of trust for online groups

This thesis investigated the link between trust and language in online dyadic, online group, and virtual community interactions. The first two empirical studies revealed that positive emotion is reliably linked to trust, that is to say that dyads and groups that produce more positive emotion words show greater trust. In addition, by priming group members to believe their group was either high or low in trustworthiness, the second empirical study revealed that group members produce more positive emotion words as a consequence of greater trust. A third study revealed an additional important language phenomena to trust, this was a type of linguistic mimicry known as linguistic style matching (LSM). The study guided groups through established phases of group development (relational, task, and task resolution), findings revealed that LSM in the early, relational phase, predicted trust. Further analysis of the relationship between phase of development, positive emotion words and LSM revealed that when LSM was low in the relational phase, positive emotion once again became a cue used to trust in subsequent task phases. The Relevant and Reliable Language Theory was proposed to explain the phase of group development dependent effects of LSM and positive emotion on trust. In short, the theory states that language must be relevant, i.e. the group is still undecided regarding trust judgements and still seeks trust relevant information, and reliable, i.e. in a given context, the language must be considered a genuine trust signal, and not one that appears ‘faked’ by ‘opportunists’. Based on the novel theory, it was hypothesised in a forth study that disrupting LSM in an early relational phase, and positive emotion in a subsequent task phase (contexts where LSM and positive emotion were proposed to be most relevant and reliable to trust), would have the most detrimental effect on trust. A confederate implementing these disruptions, relative to a comparable control, supported the theory; with groups who were subject to the ‘strong’ disruption producing lower trust behaviour than the control group. A final study extended finding to real world online interactions in a virtual community focused on discussing credit card fraud, i.e. a criminal online group. The discussions were relational, rather than task focused, thus The Relevant and Reliable Language Theory predicted that LSM would be the most important language variable related to trust. The theory was supported as LSM, but not positive emotion, ebbed and flowed in line with predicted levels of trust.
SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells

Abstract Osteosarcoma (OS) patients often exhibit pulmonary metastasis, which results in high patient mortality. Our present study established the doxorubicin (Dox) resistant human OS MG-63 and HOS cells and named them MG-63/Dox and HOS/Dox, respectively. The Dox resistant OS cells had greater invasion ability than that of parental cells. The expression of ZEB1, while not FOXM1, Snail, HIF-1α, or Sp1, was significantly increased in Dox resistant OS cells. Silencing of ZEB1 can attenuate the metastasis and increase Dox sensitivity of MG-63/Dox and HOS/Dox cells. The upregulation of ZEB1 can increase of the expression of interlukin-6 (IL-6). Anti-IL-6 inhibited the invasion and increase the Dox sensitivity of MG-63/Dox and HOS/Dox cells. There was no significant difference of ZEB1 mRNA between Dox resistant and control cells. The upregulation of ZEB1 in Dox resistant OS cells can be attributed to the increase of protein half-life. This was confirmed by results that the inhibitor of proteasomal degradation can increase ZEB1 in Dox resistant OS cells. Over expression of SIAH1 can inhibit the expression of ZEB1 and increase the Dox sensitivity of MG-63/Dox and HOS/Dox cells. Collectively, we confirmed that SIAH1 induced ZEB1 is involved in the Dox resistance of OS cells.
Improved gradient descent bit flipping decoder for LDPC codes on BSC channel

: Low-Density Parity-Check (LDPC) codes have capacity-ap-proaching error-correction performance which makes them popular in communication system. Gradient descent bit ﬂ ipping (GDBF) algorithms show an error correction capability superior to most known BF algorithms. In this paper, we propose an improved gradient descent bit ﬂ ipping (IGDBF) algorithm for LDPC codes on BSC channel. Compared to GDBF algorithm, the proposed algorithm reconstructs the composition of energy function, and adds a penalty term to help it converge. Simulations show that the proposed algorithm has good performance and fast convergence rate.
Utilizing Online Collaborative Games to Facilitate Agile Software Development

Effective collaboration and interaction among the development team and between the team and the customer as well as proactive attitude in initiating and implementing improvements play vital roles in the success of agile projects. The challenge is how to address these social aspects since neither the Agile Manifesto nor the Scrum Guide specify techniques that aid the human side of software development. To fill this gap, we developed a web portal which provides 8 collaborative games to be used in agile software development. The feedback received from a Scrum team, who leveraged the games in an industrial project conducted in OKE Poland, indicates that our approach improves participants' communication, motivation, commitment, and creativity.
Resonant transmission through periodic subwavelength real metal slits in the terahertz range

This article investigates the resonant transmission characteristics of periodic subwavelength slits on real metallic plates at terahertz frequencies. By applying the eigenvalues of the slit to the mode matching technique (MMT), the transmission characteristics of the periodic subwavelength slits can be resolved as function of the gap width, plate thickness, and frequency. The resulting transmittance of the proposed method is then verified by comparing it with a commercial electromagnetic simulation software. This study demonstrates that the proposed MMT is suitable for calculating the transmittance of the periodic metal-insulator-metal slits on the real metal material and provides in-depth intuition for resonance phenomena using the modal approach.
Familiarity effects in visual word recognition

This thesis is an investigation of two different aspects of familiarity processes involved in visual word recognition. The first is how capitalisation influences visual word recognition. The second is the role played by onset, nucleus and coda in nonword recognition. A familiar aspect of proper names in English, is that they are printed with an initial capital letter. Two experiments investigated the effects of the capitalisation of the initial letter of nonwords. It was found that subjects generate fewer pronunciations for initially capitalised nonwords than for those which were not capitalised. I suggest that in English initial capitalisation acts as a cue strong enough to prompt readers to perceive unfamiliar strings of letters as belonging to the category of proper names. As a result, the phonological domain used to retrieve the pronunciation of initially capitalised strings becomes more restricted than that used for the non-capitalised unfamiliar strings. These results extend the applicability of Brennen's theory for proper names, which is based on the size of the set of plausible phonologies of a word. In a third experiment, pairs of nonwords had their familiar visual appearance manipulated in terms of first and last letter capitalisation, in a same-different matching task. Faster response times were obtained for those nonword pairs that kept a more familiar aspect (e.g., pairs in which the first letter was capitalised as opposed to others in which the last letter was capitalised). These results are explained in terms of Besner and Jonhston (1989) "orthographic familiarity route". I propose the transformation model as an explanation for the mechanisms by which this route operates. Nonwords are an important aspect of this thesis. A new algorithm was developed for the creation of monosyllabic nonwords in which the frequency of their onsets, nuclei and codas could be controlled carefully. This gave us the opportunity to study the influence of orthographic neighborhood in visual word recognition. The findings here are in agreement with previous studies which show the recognition of an item to be influenced by the presence of neighbours. It has been hypothesized that familiarity effects in visual word recognition can only be found in tasks where identification mechanisms are not implicated. Here, a new category of words, namely brand names, was used to test this hypothesis. There are many reasons why brand names are a more appropriate class of words than acronyms to be used in this type of investigation. The results obtained confirm the hypothesis above. Previously, acronyms had been the only class of words used to test this hypothesis.
Non-Fringe Subtrees in Conditioned Galton - Watson Trees

We study $S(\mathcal{T}_{n})$, the number of subtrees in a conditioned Galton—Watson tree of size $n$. With two very different methods, we show that $\log(S(\mathcal{T}_{n}))$ has a Central Limit Law and that the moments of $S(\mathcal{T}_{n})$ are of exponential scale.
Secure Cloud Computing : Risk Analysis for Secure Cloud Reference Architecture in Legal Metrology

In the field of Legal Metrology, a risk assessment is demanded by European directives for certain measuring instruments. In this paper, a previously published reference cloud architecture will be subjected to such an assessment to demonstrate its suitability for providing adequate software protection. A specially tailored and standardized method is used to identify essential threats and common attack vectors for the reference architecture. With the help of calculated probability score and risk factors, the fulfillment of the essential requirements of the applicable European directives are shown. Furthermore, Attack Probability Trees are applied to more complex scenarios to identify suitable countermeasures to increase the resilience level where necessary.
Effective treatment with omalizumab of a patient with spontaneous chronic urticaria and eosinophilic esophagitis

Abstract This article reports the clinical history of a patient who had been affected by chronic spontaneous urticaria for 13 years, resistant to currently recommended therapy, and who was also diagnosed eosinophilic esophagitis. The anti-IgE monoclonal antibody omalizumab was rapidly effective and induced the clinical remission of both diseases.
Unconsciously interactive Films in a cinema environment—a demonstrative case study

ABSTRACT ‘Many worlds’ is a short narrative live-action film written and directed so as to provide multiple linear routes through the plot to one of four endings, and designed for showing in a cinema environment. At two points during the film, decisions are made based on audience bio-signals as to which plot route to take. The use of bio-signals is to allow the audience to remain immersed in the film, rather than explicitly selecting plot direction. Four audience members have a bio-signal measured sensor for each person: ECG (heart rate), EMG (muscle tension), EEG (‘brain waves’) and Galvanic Skin Response (perspiration). The four are interpreted as a single average of emotional arousal. ‘Many worlds’ was the first live-action linear plotted film to be screened in a cinema to the general public utilizing multiple biosensor types. The film has been shown publically a number of times, and lessons learned from the technical and cinematic production are detailed in this paper.
Changing aims of computing education: a historical survey

ABSTRACT Computing education has been an important and sometimes contentious issue ever since the advent of modern computing. Debates about computing education have closely followed job markets, technological development, academic interests, societal concerns, and changes in the perception of computing. The themes in computing education debates can be characterized by emergence and formation, standardization and organization, accommodation to change, and divergence. The focus of computing education has expanded outward from the computer to programming, algorithms, and information, as well as to the organizational, social, and cultural environment of computer systems. This survey gives computing education researchers an overview of some of the central issues and disputes in computing education over the brief history of modern computing. The survey highlights the emergence of educational initiatives, concepts, joint efforts, and institutions of computing education, and outlines the relatively short history of computing education research. The survey is structured around four overlapping themes: computing education as technological training, as training for software development, as a central element for the field’s academic recognition, and as training for computational problem-solving in any domain of knowledge. Each theme has played a role throughout the history of modern computing, but their relative emphases have changed over the years.
Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature

Hidradenitis suppurativa (HS) is a chronic skin disease of the pilo-sebaceous apocrine unit characterized by significant inflammation and an impaired quality of life. The pathogenesis of HS remains unclear. To determine the HS skin and blood transcriptomes and HS blood proteome, patient data from previously published studies were analysed and integrated from a cohort of patients with moderate to severe HS (n = 17) compared to healthy volunteers (n = 10). The analysis utilized empirical Bayes methods to determine differentially expressed genes (DEGs) (fold change (FCH) >2.0 and false discovery rate (FDR) <0.05), and differentially expressed proteins (DEPs) (FCH>1.5, FDR<0.05). In the HS skin transcriptome (lesional skin compared to non-lesional skin), there was an abundance of immunoglobulins, antimicrobial peptides, and an interferon signature. Gene-sets related to Notch signalling and Interferon pathways were differentially activated in lesional compared to non-lesional skin. CIBERSORT analysis of the HS skin transcriptome revealed a significantly increased proportion of plasma cells in lesional skin. In the HS skin and blood transcriptomes and HS blood proteome, gene-sets related to the complement system changed significantly (FDR<0.05), with dysregulation of complement-specific DEGs and DEPs. These data point towards an exaggerated immune response in lesional skin that may be responding to commensal cutaneous bacterial presence and raise the possibility that this may be an important driver of HS disease progression.
A case study of balance and integration in worth-focused research through design

Understandings of, and objectives for, Interaction Design have been extended over the last few decades. Firstly, a single user-centred focus for Interaction Design is no longer regarded as adequate where any single central focus for design is now questioned. Post-centric approaches such as Balanced, Integrated and Generous (BIG) Design propose to achieve a broadened worth-focused content scope for Interaction Design, where worth is the balance of increasing benefits over reducing costs and generosity of choice. Secondly, there has been a broadened scope for disciplinary values in Human-Computer Interaction research, with the initial engineering and human science values of User-Centred Design and Human-Computer Interaction now complemented by the rapidly maturing creative field of Research through Design (RtD). Thirdly, RtD as a form of creative reflective practice does not have a sequential process, but needs parallel activities that can achieve total iteration potential (i.e., no restrictions on iteration sequences). Structured reflective tools such as the Working to Choose Framework may reveal this potential. An important opportunity remained that a complete challenging case study that integrated these domains (worth-focus) and tools (RtD, structured reflection) was carried out. The case study addressed the challenging social issues associated with supporting care circles of individuals with disabilities. It is original in completely tracking the combination of RtD with worth-focused Interaction Design, supported by established user-centred practices. The resulting research has made contributions through the tracking of the RtD process to: worth-focused design and evaluation resources; structured reflection; demonstration of innovative parallel balanced and integrated forms of iteration; and to future social innovation for disability support.
Methodology of Constructing and Analyzing the Hierarchical Contextually-Oriented Corpora

Methodology of Constructing and Analyzing the Hierarchical structure of the Contextually -Oriented Corpora was developed. The methodology contains the following steps: Contextual Component of the Corpora's Structure Building; Text Analysis of the Contextually-Oriented Hierarchical Corpus. Main contribution of this study is the following: hierarchical structure of the Corpus provides advanced possibilities for identification of the Morphological and Structural features of texts of different tonalities; Contextual, Morphological and Structural specificity of texts with tonality, originally assigned by the authors, has significant differences; exist the certain thought and writing style Templates, under the influence of which the formation of texts of various tonalities takes place. As basic features of such templates for the texts of the two basic (positive/negative) tonalities could be used: Contextual Structure, Morphological Types, Emotional Features, Writing Style and Vocabulary Richness. For verification of the proposed methodology, a case study of Polish-language film reviews Dataset was used.
Zweidimensionale Geschwindigkeitsmessung texturierter Oberflächen mit flächenhaften bildgebenden Sensoren

Die Arbeit beschreibt Methoden zur bildbasierten 2D Geschwindigkeitsmessung texturierter Oberflachen. Es werden zwei Verfahren dargestellt und diskutiert: Bei der Einzelbild-Analyse werden die Betragsspektren gepulst belichteter Bilder analysiert; die Bildfolgen-Analyse wendet Korrelationsmethoden zur Verschiebungsschatzung zwischen zwei Bildern an. Ein weiterer Schwerpunkt ist die Anwendung der Verfahren zur schlupffreien Messung von Geschwindigkeit und Schwimmwinkel bei Kraftfahrzeugen.
Identification by Tn‐seq of Dickeya dadantii genes required for survival in chicory plants

Summary The identification of the virulence factors of plant‐pathogenic bacteria has relied on the testing of individual mutants on plants, a time‐consuming process. Transposon sequencing (Tn‐seq) is a very powerful method for the identification of the genes required for bacterial growth in their host. We used this method in a soft‐rot pathogenic bacterium to identify the genes required for the multiplication of Dickeya dadantii in chicory. About 100 genes were identified showing decreased or increased fitness in the plant. Most had no previously attributed role in plant–bacterium interactions. Following our screening, in planta competition assays confirmed that the uridine monophosphate biosynthesis pathway and the purine biosynthesis pathway were essential to the survival of D. dadantii in the plant, as the mutants ∆carA, ∆purF, ∆purL, ∆guaB and ∆pyrE were unable to survive in the plant in contrast with the wild‐type (WT) bacterium. This study also demonstrated that the biosynthetic pathways of leucine, cysteine and lysine were essential for bacterial survival in the plant and that RsmC and GcpA were important in the regulation of the infection process, as the mutants ∆rsmC and ∆gcpA were hypervirulent. Finally, our study showed that D. dadantii flagellin was glycosylated and that this modification conferred fitness to the bacterium during plant infection. Assay by this method of the large collections of environmental pathogenic strains now available will allow an easy and rapid identification of new virulence factors.
Self-recovery scheme for audio restoration using auditory masking

Self-recovery schemes identify and restore tampering, using as a reference a compressed representation of a signal embedded into itself. In addition, audio self-recovery must comply with a transparency threshold, adequate for applications such as on-line music distribution or speech transmission. In this manuscript, an audio self-recovery scheme is proposed. Auditory masking properties of the signals are used to determine the frequencies that better mask the embedding distortion. Frequencies in the Fourier domain are mapped to the intDCT domain for embedding and extraction of reference bits for signal restoration. The contribution of this work is the use of auditory masking properties for the frequency selection and the mapping to the intDCT domain. Experimental results demonstrate that the proposed scheme satisfies a threshold of -2 ODG, suitable for audio applications. The efficacy of the scheme, in terms of its restoration capabilities, is also shown.