Miracle-dz/UniFAR-FTUs huggingface dataset:
In pursuit of truth: A critical examination of meta-analyses of cognitive behavior therapy

Abstract Objective: Three recent meta-analyses have made the claim, albeit with some caveats, that cognitive-behavioral treatments (CBT) are superior to other psychotherapies, in general or for specific disorders (e.g., social phobia). Method: The purpose of the present article was to examine four issues in meta-analysis that mitigate claims of CBT superiority: (a) effect size, power, and statistical significance, (b) focusing on disorder-specific symptom measures and ignoring other important indicators of psychological functioning, (c) problems inherent in classifying treatments provided in primary studies into classes of treatments, and (d) the inclusion of problematic trials, which biases the results, and the exclusion of trials that fail to find differences among treatments. Results: When these issues are examined, the effects demonstrating the superiority of CBT are small, nonsignificant for the most part, limited to targeted symptoms, or are due to flawed primary studies. Conclusion: Meta-analytic evidence for the superiority of CBT in the three meta-analysis are nonexistent or weak.
Fitts' Law and Human Control of an Electromyographic Signal from the Biceps Brachii Muscle Group

Six human subjects performed a modified Fitts' test by moving an electromyographic signal between two targets on a computer screen. For five out of six subjects, the results were consistent with Fitts' Law with correlation coefficients ranging between 29% and 72%. The low correlation of the sixth subject (0.6%) may have been due to electrode misplacement and the adoption of a "strategy" in how she performed the task. Thesis Advisor: Dr. Mandayam A. Srinivasan Title: Senior Research Scientist Thesis Supervisor: Dr. David W. Schloerb Title: Research Scientist
The relative role of genetic and environmental factors in migraine without aura

Objective: To clarify the relative role of genetic and environmental factors in the etiology of migraine without aura (MO). Methods: The study population consisted of 5,360 twins, 1,013 monozygotic (MZ) and 1,667 same-gender dizygotic (DZ) twin pairs, from the population-based Danish Twin Registry. A total of 87% completed a simple validated questionnaire screening for migraine. All twin pairs, in whom at least one twin had self-reported migraine or severe headache with accompanying symptoms, were interviewed via telephone by a physician. Ninety percent of the eligible twins were interviewed. Probandwise concordance rates and correlations in liability were calculated, and structural equation model-fitting analyses were applied to quantitate the relative role of genetic and environmental factors in the etiology of MO. Results: The probandwise concordance rate was higher in MZ than DZ twin pairs (0.43 versus 0.31; 95% CI, 0.36 to 0.49 versus 0.26 to 0.36). The correlation in liability was higher in MZ than in DZ twin pairs (0.62 versus 0.41; 95% CI, 0.50 to 0.74 versus 0.29 to 0.53). Structural equation model fitting indicated a highly significant genetic component, because a model with both genetic and environmental components fitted significantly better than a model with only environmental components. The best fitting model implied that the liability to MO resulted from additive genetic effects (61%; 95% CI, 49 to 71%)) and individual-specific environmental effects (39%; 95% CI, 29 to 51%). Conclusion: This study indicates that genetic factors play a role in the etiology of migraine without aura. The genetic variability is additive, with a negligible contribution of nonadditive genetic effects. The genetic contributions were similar in men and women despite a higher prevalence in women. Environmental factors are equally important and these factors are individual to the migraineurs.
Design and R&D for MITICA thermal sensors

In MITICA, the ITER neutral beam injector prototype, in-vessel components will be instrumented with thermocouples for material thermal measurements and water cooling calorimetry. A subset of MITICA thermal sensors will be installed in ITER Neutral Beam Injectors and it will consist of type N Mineral Insulated (MI) thermocouples with Ultra High Vacuum (UHV) compatible termination. Each sensor will end with a metallic/ceramic transition from MI cable to two pins suitable for direct integration into a Remote Handling (RH) compatible connector. A set of sensor prototypes has been procured and tests demonstrate the measuring capability and UHV compatibility: electrical insulation, conductivity, dielectric, and helium bombing tests passed, thus satisfying the technical requirements. The in-vessel thermal sensor system extends from the sensing junction up to the safety important feedthroughs at the vessel vacuum barrier. The whole cabling has been designed to be RH compatible to perform maintenance and replacement of components. The in-vessel RH compatible connector and the safety important feedthrough have been developed to house sensor cabling in a reliable and compact design, coping with all requirements. The design of different sensing junction types has been integrated with reliable mechanical fastenings, providing good and stable thermal contact. The paper describes the thermal system requirements and design, the qualification procedure undertaken on prototypes and the test results.
Design and simulation of electronic infrastructure of a DC smart Micro Grid

Concepts of Micro-Grids are proposed to address primarily various issues related to integration of small scale renewable and electricity supply reliability. Micro-grids are Low Voltage networks that usually operate interconnected with the main Medium Voltage network but, in case of emergency, can run autonomously. In such networks Renewable Energy Sources (RES) are foreseen to have rather high penetration mainly photovoltaics and small scale Wind Turbines. In this paper, the electronic infrastructure of micro-grid is expressed. Then discussed the reasons for its complexity and the possibility of reducing the elements of electronic circuits are investigated. The reason for this is in order to compact DC micro-grid system for electrification to places like villages. This document gives Technical and economic comparison that is the reason for the brief electronic infrastructure of DC micro-grid. Simulation in Matlab Simulink is used to show the effectiveness of this method.
Treatment of adult T‐cell leukemia/lymphoma: past, present, and future

Adult T‐cell leukemia/lymphoma (ATLL) is a peripheral T‐cell malignancy caused by human T‐cell lymphotrophic virus type I. Clinical manifestations of ATLL range from smoldering to chronic, lymphoma and acute. Patients with acute and lymphoma type ATLL require therapeutic intervention. Conventional chemotherapeutic regimens used against other malignant lymphoma have been administered to ATLL patients, but the therapeutic outcomes of acute and lymphoma type ATLL remain very poor. Promising results of allogeneic stem cell transplantation (SCT) for ATLL patients have recently been reported and the treatment outcome might be improved for some ATLL patients. Besides conventional chemotherapy and SCT, interferon, zidovudine, arsenic trioxide, targeted therapy against surface molecule on ATLL cells, retinoid derivatives, and bortezomib have been administered to ATLL patients in pilot or phase I/II studies. Further studies are required to confirm the clinical benefits of these novel therapeutics. This article reviews the current status and future directions of ATLL treatment.
Design of the GNSS Clock Frequency Abnormal State Emulator

Clock signals is the reference signal of the frequency synthesis signal acquisition and the time synchronization in the GNSS. The clock frequency abnormal state make a direct impact of signal integrity monitoring. The theoretical analysis and software simulation are the commonly way to studying on the abnormal state clock frequency signal and it's impact for GNSS system applications. In order to test and evaluate this impact, The paper designs and implements navigation clock abnormal state impersonation system. And it designs a clock abnormal impersonation emulator, based on the simulation software Mat lab and the Programmable DC Power Analyzer Agilent N6705 and high-precision adjustable bias voltage of Voltage Controlled X'tal Oscillator (VCXO). Firstly, through the Mat lab simulation to generate a specific pattern of tiny voltage control words, a particular feature of the control voltage generated by the programmable DC power analyzer, adjust the controllable bias voltage of VCXO, then the corresponding micro-controllable variation state superimposed on the main clock, so that the clock contains various abnormal state, at last using Frequency Counter SR620 to measure the output of the system to analyze the results. The simulation and experimental results show that the system can correctly emulate the output frequency clock rate of the abnormal state, including white-noise characteristics of the variable amplitude fluctuations. Furthermore the size, duration, amplitude of the above-mentioned characteristics can be controlled adjustable. The clock abnormal state impersonation emulator can be widely used in the testing and emulating of abnormal clock frequency signal for GNSS system.
Los sistemas personalizados de dosificación y su aportación a la seguridad de los pacientes

Los sistemas personalizados de dosificacion y su aportacion a la seguridad de los pacientes Los Sistemas Personalizados de Dosificacion (SPD) son un sistema de reacondicionado donde el farmaceutico organiza los medicamentos de forma farmaceutica solida que toma un determinado paciente durante una semana, siguiendo la pauta prescrita. El uso de los SPD esta incluido en las practicas y politicas de salud de diferentes paises con el objetivo de facilitar la administracion de los medicamentos por parte de los pacientes para, a su vez, aumentar la adherencia a los tratamientos. Existen pocos datos sobre la estabilidad de los medicamentos en dispositivos tipo SPD, constituyendose en un tema de investigacion prioritario y de interes en cuanto a la seguridad del paciente, ya que son muchos los medicamentos potencialmente inestables y potencialmente utilizables en SPDs para los que no existe informacion contrastada. La presente Tesis se presenta como un compendio de 4 articulos publicados en revistas indexadas con factor de impacto. En la primera publicacion, se evalua las caracteristicas de transmision de vapor de humedad de uno de los SPD mas comunmente usados en Espana, para conocer si este cumple o no con los requisitos establecidos por la farmacopea americana (USP) para este tipo de envases. La permeabilidad a la humedad es una de las principales caracteristicas a tener en cuenta, siendo la humedad ambiental uno de los factores mas importantes que pueden modificar la estabilidad de los medicamentos. Los resultados de esta primera publicacion muestran que el SPD objeto de estudio obtiene el grado maximo de proteccion frente a la humedad, y por lo tanto cumple con los requisitos que dicta la USP para este tipo de dispositivos (al menos Clase B). En las siguientes publicaciones se determina la estabilidad de tres medicamentos reacondicionados en el SPD previamente estudiado, durante un tiempo superior al previsto para el uso de estos dispositivos y sometido a condiciones de temperatura y humedad controladas, correspondientes a las Zonas Climaticas I/II (25°C±2°C/60% HR ±5% HR). Estos articulos son los primeros estudios sobre la estabilidad a largo plazo en SPD de omeprazol capsulas, enalaprilo comprimidos y lamotrigina comprimidos dispersables/masticables (CDM), los cuales, debido a alguna de sus caracteristicas fisico-quimicas, no se recomendaba su uso en este tipo de dispositivos. Los resultados publicados muestran que es adecuado re-acondicionar en SPDs de grado maximo de proteccion frente a la humedad, omeprazol capsulas y enalaprilo comprimidos durante un periodo de 60 dias, y lamotrigina CDM durante un periodo de 14 dias. Ademas de establecer como eje central los resultados obtenidos a traves de los estudios especificos reflejados en los 4 articulos publicados, la revision bibliografica realizada en esta Tesis, permitio aportar aspectos sobre la seguridad del paciente relacionada con los SPD, a traves de recomendaciones sobre el servicio profesional farmaceutico asistencial con SPD.
Respuesta hepática durante la isquemia-reperfusión pulmonar modulada con precondicionamiento isquémico en un modelo experimental de autotrasplante pulmonar en cerdo

El dano por isquemia-reperfusion es reconocido como un serio problema que acompana a diversos procedimientos medicos y quirurgicos habituales tales como la terapia trombolitica, el trasplante de organos, la angioplastia coronaria y el by-pass cardiopulmonar. La isquemia-reperfusion pulmonar induce una respuesta inflamatoria local en el propio parenquima pulmonar caracterizada por dano alveolar inespecifico, edema pulmonar e hipoxemia. La isquemia-reperfusion pulmonar tambien induce una respuesta inflamatoria sistemica con afectacion de organos remotos, la cual es incluso mas danina que sus efectos locales. Estudios previos han demostrado en modelos clinicos y experimentales que el higado es particularmente sensible a la liberacion de mediadores inflamatorios, hecho que ocurre tras la isquemia-reperfusion de organos remotos tales como: rinon, intestino y musculo esqueletico. Se ha comprobado que el precondicionamiento isquemico directo es capaz de proteger a diversos organos frente al dano por isquemia-reperfusion. Nuestro grupo ha demostrado previamente en un modelo de autotrasplante pulmonar en cerdo, que el precondicionamiento isquemico atenua el dano por isquemia-reperfusion pulmonar mediante la prevencion del aumento de los metabolitos de peroxidacion lipidica, la activacion leucocitaria y las citoquinas proinflamatorias en el parenquima pulmonar.
SCide: Identification of Stabilization Centers in Proteins

SUMMARY SCide is a program to identify stabilization centers from known protein structures. These are residues involved in cooperative long-range contacts, which can be formed between various regions of a single polypeptide chain, or they can belong to different peptides or polypeptides in a complex. The server takes a PDB file as an input, and the result is presented in graphical or text format. AVAILABILITY SCide is available on the web at http://www.enzim. hu/scide. The source code can be obtained from the authors on request.
A novel compact chipless RFID tag and near-field reader

A novel compact design of a fully printable chipless RFID tag and two near-field reading techniques for the designed tag are presented in this paper. The tag is made of two multiple slot-loaded rectangular patches. Slots with adjacent frequencies are placed alternately into two patches to reduce the mutual coupling between the slot resonators. The tag measurements are done for both proximity reading and slot card reading techniques. This single sided compact tag has higher data capacity and lower cost compared to the existing printable chipless tags. It can be incorporated in paper or plastic-based items such as ID cards, tickets and banknotes as an enhancement in security in a user friendly way.
Affinity Labelling and Identification of the High‐Affinity Choline Carrier from Synaptic Membranes of Torpedo Electromotor Nerve Terminals with [3H]Choline Mustard

Abstract: The physiological mechanisms regulating activity of the sodium‐dependent, high‐affinity choline transporter and the molecular events in the translocation process remain unclear; the protein has not been purified or characterized biochemically. In the present study, [3H]choline mustard aziridinium ion ([3H]ChM Az), a nitrogen mustard analogue of choline, bound irreversibly to presynaptic plasma membranes from Torpedo electric organ in a hemicholinium‐sensitive, and sodium‐, time‐, and temperature‐dependent manner. Specific binding of this ligand was greatest when it was incubated with membranes in the presence of sodium at 30°C. Separation of the 3H‐labelled membrane proteins by sodium dodecyl sulfate‐polyacrylamide gel electrophoresis revealed that most of the radiolabel was associated with a polypeptide of apparent molecular mass of ∼42,000 daltons; labelling of this species was abolished in membranes incubated with ligand in the presence of HC‐3. Two other 3H‐labelled polypeptides were detected, with apparent molecular masses of ∼58,000 and 90,000 daltons; radiolabelling of the former was also HC‐3 sensitive. [3H]ChM Az may be a useful affinity ligand in the purification of the choline carrier from cholinergic neurons.
Role of catalase and oxidative stress in hepatic peroxisome proliferator‐induced morphological transformation of syrian hamster embryo cells

Several hepatic peroxisome proliferators (HHPs), such as di(2‐ethylhexyl)phthalate (DEHP), mono(2‐ethylhexyl)‐phthalate, clofibrate and tiadenol, induce morphological transformation of Syrian hamster embryo (SHE) cells in vitro. According to one hypothesis, the hepatocarcinogenic effect of HPPs is caused by an oxidative stress due to increased H2O2‐production from the strongly induced peroxisomal β‐oxidation of fatty acids. Thus, increased transformation frequencies by HPPs should be obtained when catalase was inhibited by 3‐amino‐1, 2, 4‐triazole (amitrole). However, coexposure to HPPs and amitrole did not enhance the transformation frequencies for any of the HPPs. The sensitivity of SHE cells for oxidative agents was studied by using menadione and H2O2. Menadione only induced transformation at a toxic concentration, while H2O2 induced transformation at non‐toxic concentrations. To study the generation of oxidative radicals in SHE cells, electron spin resonance was employed. No oxidative radical formation was detected in tiadenol‐ or DEHP‐exposed SHE cells. When menadione or H2O2 were added during the measurements, oxidative radicals were found. A transmission electron microscopic study showed a small number of peroxisomes, and did not reveal any increase in the number of peroxisomes in clofibrate treated SHE cells.
A simplified sensorless vector control based on the average of the DC bus current

This paper describes a simplified sensorless vector control for permanent magnet synchronous motors (PMSM) using the average of the DC bus current. This method sets up the drive control system at relatively inexpensive because the micro controller does not need to have a precise timer and the calculation load is slight. The proposed method effectively changes two different current estimation methods in accordance with the operation mode. First, the controller estimates d-axis current and identifies back-EMF parameter in synchronous operation mode at the low speed region. The identification error of back-EMF parameter affects efficiency of the proposed system, so it needs to be zero. Second, the controller estimates q-axis current in vector control mode. The identified parameter and q-axis current define voltage reference to realize high efficiency drive. Experimental results confirm the effectiveness of proposed method.
Intravenous self‐administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleus

The reinforcing properties of nicotine involve actions at nicotinic acetylcholine receptors located on dopamine (DA) neurons in the ventral tegmental area (VTA). The pedunculopontine tegmental nucleus (PPTg) is involved in the regulation of these DA neurons, and those of the substantia nigra pars compacta (SNc). The PPTg can be subdivided into anterior (aPPTg) and posterior (pPPTg) regions on the basis of its innervation of midbrain DA neurons – the pPPTg innervates both VTA and SNc while the aPPTg innervates SNc. As the reinforcing actions of nicotine depend on its actions in the VTA more than SNc, it was hypothesized that excitotoxic lesions of pPPTg would alter nicotine reinforcement, measured by intravenous self‐administration, while lesions of aPPTg would not. Rats were given ibotenate lesions of pPPTg or aPPTg, followed by intravenous catheterization. Intravenous self‐administration (IVSA) of nicotine (0.03 mg/kg/inf) was carried out until a stable response baseline was reached. A dose–response function for nicotine was then established. There was no significant effect of aPPTg lesions on nicotine IVSA, while IVSA was significantly elevated following pPPTg lesions, compared with both sham lesioned controls and aPPTg excitotoxin lesioned rats. This was found across all doses, including saline, of the dose–response function. The differential effect of aPPTg lesions and pPPTg lesions suggests that disruption of regulatory innervation from pPPTg results in altered regulation of VTA DA neurons. The resulting change in nicotine self‐administration behaviour was hypothesized to reflect either a reduction in intrinsic nicotine reward value, or enhancement of associative incentive salience.
Applicability of the CANTAB-PAL Computerized Memory Test in Identifying Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

Aim: To compare the diagnostic accuracy of a computerized test, the CANTAB paired associate learning (PAL) to that of an established and validated noncomputerized test, the CERAD Wordlist Learning task in differentiating between normal aging, aMCI and AD in a cross-sectional design. Methods: 58 participants were assessed (19 with mild probable AD, 17 aMCI, 22 healthy controls). Results: The variables found to best discriminate between the three groups were the CANTAB PAL total errors adjusted (p < 0.0001, 81.0% of the cases correctly classified), and CERAD Wordlist Learning Delayed Recall (p < 0.0001, 77.6% of the cases correctly classified). Using both PAL total errors adjusted and Wordlist Learning Delayed Recall, 84.5% of the cases were correctly classified. Discussion: The results suggest that the CANTAB could be used for screening of AD-typical memory impairment.
Evaluating Uncertain Income Streams under a Regime-Switching Process

This paper extends the dynamic programming, utility maximization model proposed by Wang (2004) to value an investment opportunity whose income streams follows a regime-switching process in incomplete markets. Specifically, the model is applied to solve for certainty equivalent of an investment opportunity in a two-regime, five-branch lattice. The application is then expanded to a more general case of multi-nodes and multi-regimes. The finding indicates that investor’s risk attitude is a non-trivial factor in investment decision-making. When the investor is more risk-averse, the certainty equivalent of an investment opportunity is shown to be lower. Numerical analysis also reveals that the inverse relationship between certainty equivalent and risk attitude is less sensitive when the market is less incomplete. Finally, the application of valuing an investment opportunity whose project value follows a discrete regime-switching process has been successfully integrated into the utility maximization model.