Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinicopathological analysis of 598 malignant lymphomas in Taiwan: Seven‐year experience in a single institution

The clinicopathological characteristics of malignant lymphomas vary according to geography. The purpose of this study is to determine the distribution and clinicopathological characteristics of malignant lymphomas in Taiwan. Archival tissue from 598 malignant lymphomas during the period of 1995–2002 was retrieved. They were reclassified according to the World Health Organization classification system. Clinical data, including age, gender, clinical staging, and follow‐up, were scrutinized. There were 330 males and 268 females. The median age at onset of disease was 56 years for B‐cell lymphoma (BCL), 50 years for T/NK‐cell lymphoma (TCL), and 26 years for Hodgkin's lymphoma (HL). BCL accounted for 80.6%, TCL for 12.4%, and HL for 7%. The major subtypes of non‐HL were diffuse large B‐cell lymphoma, follicular lymphoma, plasma cell myeloma, marginal zone lymphoma of mucosa‐associated lymphoid tissue type, mantle cell lymphoma, unspecified peripheral TCL, and nasal type T/NK‐cell lymphoma. Nodular sclerosing subtype was the most common in HL. The frequencies of TCL and HL were relatively low. For histological subtype, enteropathy‐type TCL and primary bone marrow HL had higher frequency and poorer prognosis. The 5‐year overall survival of BCL, TCL, and HL was 58.9, 34.7, and 83.5%, respectively. To the best of our knowledge, this is the largest series study of malignant lymphoma in Taiwan. Immunophenotype, histological subtype, and clinical stage play significant roles in prognosis (P < 0.05). Am. J. Hematol. 81:568–575, 2006. © 2006 Wiley‐Liss, Inc.
Frequency response of a microwave notch filter in presence of two interfering tones

The frequency response of a microwave notch filter using a pair of magic tees has been studied theoretically as well as experimentally in this paper. This notch filter designed at 10.5 GHz eliminates the first interfering tone. When the second interference appears at the input of this notch filter the response is modified and its fails to remove the first interference because the null point of the response gets shifted upwards under the action of the second interference. The dc shift of the minimum of the response has been calculated and measured when the second interference is 520 MHz below the first interference. The theory and experiment gives a reasonable fit.
Deep Impact: Observations from a Worldwide Earth-Based Campaign

On 4 July 2005, many observatories around the world and in space observed the collision of Deep Impact with comet 9P/Tempel 1 or its aftermath. This was an unprecedented coordinated observational campaign. These data show that (i) there was new material after impact that was compositionally different from that seen before impact; (ii) the ratio of dust mass to gas mass in the ejecta was much larger than before impact; (iii) the new activity did not last more than a few days, and by 9 July the comet's behavior was indistinguishable from its pre-impact behavior; and (iv) there were interesting transient phenomena that may be correlated with cratering physics.
Effect of dentin conditioning on bond strength of fiber posts and dentin morphology: a review.

PURPOSE Post and core systems are commonly used to restore endodontically treated teeth. A durable bond between fiber posts and dentin contributes to the success of the restorative treatment. Different irrigants are used during post space preparation and various studies have investigated the effects of these chemical agents on bond strength and dentin morphology. METHODS The MEDLINE-PubMed, Cochrane, and SCOPUS databases were searched for appropriate papers addressing the effects of irrigants on bonding of fiber posts to dentin and on dentin morphology. Databases were searched from 2002 through 2012. The search was performed using a variety of keywords including fiber posts, bond strength, post space preparation, post space irrigation, and smear layer removal. RESULTS Using multiple key words and different strategies, 68 publications were initially screened. The abstracts of these 68 publications were scanned for relevance, and 50 full-text articles were selected and read in detail. Thirty publications which discussed the effect of various intracanal irrigants on bond strengths of fiber posts and dentin morphology were incorporated in this review. Following review of all relevant papers, it can be concluded that bond strengths of fiber posts to radicular dentin can be affected by the irrigants used and that various irrigants affect different types of resin cements differently.
Fast simulation of nonlinear radio frequency ultrasound images in inhomogeneous nonlinear media: CREANUIS

The simulation of ultrasound image is usually based on two main strategies: either a linear convolution or the use of an acoustics model. However, only the linear propagation of the pressure wave is considered. CREANUIS is a recent simulation tool (freely available on the Internet: http://www.creatis.insa-lyon.fr/site/en/CREANUIS) which implements the nonlinear propagation of the wave to create realistic ultrasound images [Varray et al., IEEE International Ultrasonics Symposium 201] and opens new simulations perspectives based on nonlinear propagation: amplitude modulation, pulse inversion, second harmonic inversion. The nonlinear propagation in CREANUIS is simulated using a generalization of the angular spectrum method (GASM). This approach is implemented on a graphic processing unit (GPU) for a fast computation. Moreover, in GASM simulation, the possible inhomogeneity of the nonlinear parameter can be considered. It directly impacts the increase of the harmonics during propagation and consequently the resulting RF image. These resulting images perfectly translate the nonlinear parameter change in the medium. Finally, the total computation time for CREANUIS (fundamental and second-harmonic image) compared to FieldII (fundamental image only) is reduced by a factor comprised between 2 and 4 according to the geometric considerations.
Reasoning Frameworks for Autonomous Systems

The ability to reason within an Artificially Intelligent System (AIS) denotes the ability to infer about information, knowledge, observations, and experiences, and affect changes within the AIS that enable it to perform new tasks previously unknown or to perform tasks already learned more efficiently. The act of reasoning, or inferring, allows the AIS to construct or modify representations of that the AIS is experiencing and learning. Reasoning allows the AIS to fill in skeletal or incomplete information or specifications about one or more of its domains (selfassessment). Presented here is a discussion of reasoning within the AIS that takes the form induction and abduction:
Modelling and Analysis of Multi-period Distribution-Allocation Problem in a Two-Stage Supply Chain

A supply chain has a network structure and all the production-distribution decisions involve several variables and constraints which vary both quantitatively and qualitatively. Mostly, production and distribution functions are managed independently, with little or no coordination which results in huge inventory holding costs and backorder costs. Hence, supply chains are exploring strategies to reduce the inefficiencies and the redundancies along the manufacturing/ distribution channel, which can eventually lead to a closer coordination between the various supply chain partners. One such strategy is to effectively allocate the downstream entities to the upstream entities. Hence, this paper considers a multi-period distribution- allocation problem(MPDAP) subjected to backorder and inventory constraints. It's mathematical formulation is difficult to solve due to the presence of fixed costs which causes nonlinearities in the objective function. The MPDAP is known to be Non-deterministic Polynomial-time hard problem. The complexity of the problem increases as and when more constraints are imposed into the model and problem size increases. In this work, an MPDAP is solved using an Ant colony optimization based heuristic to get a near-optimal solution. The proposed heuristic has been evaluated for the solution robustness by comparing it with that obtained using LINGO solver. A range of problem instances were considered in which suppliers, customers and time-periods were varied from 2-8. The percentage deviation of ACO cost from optimal solution obtained from LINGO was around 2%.
Glomerular expression of monocyte chemoattractant protein-1 in experimental and human glomerulonephritis.

BACKGROUND Glomerular monocytes are found in a variety of renal diseases and appear to be important in the pathogenesis of glomerular injury. The mediators responsible for recruiting monocytes to the glomerulus are not well characterized. We have recently established that cultured human mesangial cells produce the specific monocyte chemoattractant, monocyte chemoattractant protein-1 (MCP-1) in response to inflammatory cytokines commonly found in glomeruli during glomerulonephritis (GN). This suggested that MCP-1 may be involved in recruiting leukocytes to the glomerulus. To date however, there is little information regarding the expression of MCP-1 during renal disease. The present study was undertaken to investigate the in vivo expression of MCP-1 during experimental and human GN. EXPERIMENTAL DESIGN A rodent model of anti-glomerular basement membrane GN was used to investigate glomerular MCP-1 mRNA regulation and protein expression. The presence of MCP-1 in human renal tissue was studied by immunostaining kidney biopsy material from patients with a variety of glomerulopathies. RESULTS MCP-1 mRNA was transiently upregulated during the early stages of experimental GN. Message levels increased in association with the monocyte influx and correlated with expression of immunoreactive MCP-1 in the nephritic glomeruli. Glomerular MCP-1 was also found in human inflammatory glomerulopathies, but not in glomerular diseases lacking a prominent monocyte infiltrate. CONCLUSIONS These data support a role for MCP-1 in the pathogenesis of glomerular inflammation.
Cloning of Two Genetically Transmitted Moloney Leukemia Proviral Genomes: Correlation Between Biological Activity of the Cloned DNA and Viral Genome Activation in the Animal

The Mov-7 and Mov-9 substrains of mice, carrying Moloney murine leukemia virus (M-MuLV) in their germ line at the Mov-7 locus and Mov-9 locus, respectively, are different with respect to virus activation. Infectious virus appears in all mice carrying the Mov-9 locus but is not activated in animals carrying the Mov-7 locus. Consequently, only Mov-9 mice develop viremia and subsequent leukemia. The endogenous M-MuLV provirus with flanking mouse sequences corresponding to the Mov-7 and Mov-9 loci was molecularly cloned. Detailed restriction maps obtained from the cloned DNAs revealed no detectable differences in the proviral genomes. The flanking mouse sequences, however, were different, confirming that the Mov-7 and Mov-9 loci represent different integration sites of M-MuLV. Both clones induced XC plaques in a transfection assay. The specific infectivity of the clones, however, was different. A total of 10−5 XC plaques per genome equivalent were induced by the Mov-9 clone, whereas only 10−9 XC plaques per genome equivalent were induced by the Mov-7 clone. Moreover, NIH 3T3 cells transfected with the Mov-9 clone produced NB-tropic M-MuLV, whereas cells transfected with the Mov-7 clone did not produce infectious virus. The results suggest that M-MuLV integrated at the Mov-7 locus carries a mutation which prevents synthesis of infectious virus but permits XC plaque induction by partial genome expression or synthesis of noninfectious particles. Thus, the pattern of virus expression in Mov-7 and Mov-9 mice correlates with the biological properties of the respective clones. Genomic DNA from Mov-9 mice was not infectious in the transfection assay (specific infectivity < 10−7 PFU per genome equivalent). As the only difference between the genomic and the cloned Mov-9 DNA appears to be the presence of 5-methylcytosine in CpG sequences, our results suggest that removal of methyl groups by molecular cloning in procaryotes permits genome expression in transfected eucaryotic cells. Our results support the hypothesis that DNA methylation is relevant not only in genome expression in the animal but also in expression of genes transfected into eucaryotic cells.
Premature ejaculation: an observational study of men and their partners.

INTRODUCTION Premature ejaculation (PE) is the most common male sexual dysfunction affecting men and their partners. Lack of community-based data describing this condition limits understanding of PE and its outcomes. AIM To characterize PE in a large population of men with and without PE using patient-reported outcome (PRO) measures elicited from men and their partners. METHODS 4-week, multicenter, observational study of males (> or =18 years) and their female partners in monogamous relationships (> or =6 months). Screening, baseline, and follow-up visits scheduled at 2-week intervals. Clinicians diagnosed PE utilizing DSM-IV-TR criteria. Intravaginal ejaculatory latency time (IELT), measured by a stopwatch held by the partner, was recorded for each sexual intercourse experience. Subject and partner independently assessed PROs: control over ejaculation and satisfaction with sexual intercourse (0 = very poor to 4 = very good), personal distress and interpersonal difficulty (0 = not at all to 4 = extremely), and severity of PE (0 = none to 3 = severe). Results. Of the total study population (N = 1,587), 207 subjects were diagnosed with PE and 1,380 were assigned to the non-PE group. Median IELT (min) was 1.8 (range, 0-41) for PE and 7.3 (range, 0-53) for non-PE subjects (P < 0.0001). More PE vs. non-PE subjects gave ratings of "very poor" or "poor" for control over ejaculation (72% vs. 5%; P < 0.0001) and satisfaction with sexual intercourse (31% vs. 1%; P < 0.0001). More subjects in the PE vs. non-PE group gave ratings of "quite a bit" or "extremely" for personal distress (64% vs. 4%; P < 0.0001) and interpersonal difficulty (31% vs. 1%; P < 0.0001). Subject and partner assessments showed similar patterns and correlated moderately (0.36-0.57). CONCLUSIONS PE subjects reported significantly shorter IELT. Overlap in IELT distributions was observed between the PE and non-PE groups, indicating the need for additional PRO measures to characterize PE. Shorter IELT was significantly associated with reduced ejaculatory control and sexual satisfaction and increased distress and interpersonal difficulty.
On Recovering Hyperquadrics from Range Data

This paper discusses the applications of hyperquadric models in computer vision and focuses on their recovery from range data. Hyperquadrics are volumetric shape models that include superquadrics as a special case. A hyperquadric model can be composed of any number of terms and its geometric bound is an arbitrary convex polytope. Thus, hyperquadrics can model more complex shapes than superquadrics. Hyperquadrics also possess many other advantageous properties (compactness, semilocal control, and intuitive meaning). Our proposed algorithm starts with a rough fit using only six terms in 3D (four in 2D) and adds additional terms as necessary to improve fitting. Suitable constraints are used to ensure proper convergence. Experimental results with real 2D and 3D data are presented. >
Endurance training of trunk extensor muscles.

BACKGROUND AND PURPOSE The purpose of this study was to assess the effects of an endurance exercise protocol on the isometric holding time of the trunk extensor muscles (mechanical fatigue measure) and on the recorded median frequency (MF) measurements from the surface electromyogram (physiological fatigue measure). SUBJECTS Twenty-eight healthy female volunteers were selected to participate in the study. METHODS The subjects were stratified by activity level and then assigned to an exercise or a control group and tested at weeks 0, 3, and 6. Reliability (r) of the measurements, established by testing each subject twice at week 0, was . 87. Exercise group subjects trained at home twice daily for 6 weeks, progressing by established protocol. RESULTS The exercise group subjects increased their isometric holding time by 22% after 6 weeks. The control group showed no significant changes. CONCLUSION AND DISCUSSION The home program was believed to be effective for increasing isometric endurance of the trunk extensors, measured by holding time. The MF measurements prior to and just after a fatiguing contraction remained stable over time. The change in the slope of the MF with fatigue did not reach statistical significance. This physiologic measure of fatigue did not show commensurate changes with training in this group of subjects. Possible reasons for the results are discussed.
1.5 Billion Events a week - a statistical assessment for smart transport items in German FMCG supply chains

This paper is based on the research project smaRTI which is an acronym for smart reusable transport items. The project started in July 2010 and ended December 2013. One of the core ideas of the project is to use smart reusable transport items with automatic identification technology such as barcode or RFID in order to generate events, at different capture points in the supply chain of the companies. An example for a typical event, based on the GS1 EPCIS standard, would be "shipping" after an order has been dispatched. The events are uploaded in a cloud based data storage, where all of the project partners are able to monitor them in real time. This paper explains how to gross up data volume caused by around 600 relevant transport items in 34 weeks of the pilot to the fast moving consumer goods (short: FMCG) industry in Germany. It describes the strategy and the used statistical methods for the extrapolation and explains the results.
Stalking – a contemporary challenge for forensic and clinical psychiatry

Background Stalking is causing pervasive and intense personal suffering and is an area of psychiatry that is currently overlooked. Aims To review demographic and clinical characteristics of stalkers as well as the psychological consequences for victims of stalking. Method A Medline and PsycLit search was conducted on stalking, forensic psychiatry, personality disorders, de Clérambault syndrome and erotomania, with respect to the relevance of the articles selected for stalking. Results Stalkers are best thought of as a heterogeneous group whose behaviour can be motivated by different forms of psychopathology, including psychosis and severe personality disorders. Conclusions There is a clear need to arrive at a consensus on a typology of stalkers and associated diagnostic criteria. The effectiveness of psychological and pharmacological treatments have not yet been investigated. Treatment may need to be supplemented with external incentives provided by the legal system.
Multifactor dimendionality reduction analysis for gene-gene interaction of multiple binary traits

Recent advances in genotyping technology have facilitated the use of genome-wide association studies (GWAS) to successfully identify genetic variants that are associated with common complex traits. Following the successes in identification of single variants, joint identification including gene-gene interaction has been studied vigorously and produced many novel results. However, most genome-wide association studies have been conducted by focusing on one trait of interest for identifying genetic variants associated with common complex traits. Since many complex diseases having severe influences on the public health are pleiotropic, simple univariate analysis focusing on a single trait does not well detect full genetic architecture of complex diseases. For example, hyperlipidemia is diagnosed by four multiple traits: Total cholesterol (Tchl), High density lipoprotein (HDL) cholesterol, Low density lipoprotein (LDL), and cholesterol and Triglycerides (TG). Surprisingly, however, only few studies handle multiple traits simultaneously so far. Therefore, in order to improve power and reflect biological association more expansively, we investigate a multivariate approach which considers multiple traits simultaneously. Especially for the gene-gene interaction analysis for the multiple traits, we extend original multifactor dimensionality reduction (MDR) to handle multiple traits. We then demonstrate its superiority to univariate analysis through simulation studies. We confirm that the multivariate approach provides more stable and precise accuracy measures compared to univariate analysis. We applied the multivariate MDR approach to a GWA dataset of 8,842 Korean individuals and detected genetic variants associated with hypertension traits using systolic blood pressure (SBP) and Diastolic blood pressure (DBP).
SEDIMENTATION RATE ESTIMATES FROM SULFATE AND AMMONIA GRADIENTS

Data from the Ocean Drilling Program and from other marine studies are used to relate organic carbon flux preserved in the seabed with the uptake of sulfate and production of ammonia in the pore water of the sediment column. Relationships are derived that can be used to estimate recent sedimentation rates to within one order of magnitude, spanning the range from 0.1 to 100,000 m/m.y. The relationships provide a simple rule of thumb to apply to initial observations when an estimate of sedimentation rate is not readily available from biostratigraphic or isotope methods. The sedimentation rates estimated for the Leg 119 sites agree to within a factor of 3 with the biostratigraphic results.
Effects of indole alkaloids from Gardneria nutans Sieb. et Zucc. and Uncaria rhynchophylla Miq. on a guinea pig urinary bladder preparation in situ.

The effects of six indole alkaloids on parasympathetic ganglionic transmission were studied in a preparation of the guinea pig urinary bladder in situ. The effect of hirsutine on spontaneous movement of the organ was also examined. Among these alkaloids, gardneramine and hirsutine most potently inhibited the contraction of the urinary bladder induced by electrical stimulation of the pelvic nerves. Their potency was about one-half of that of hexamethonium. The effect of gardneramine was of short duration. Both alkaloids depressed the contraction induced by intraarterial dimethylphenylpiperazinium, with no antagonizing action to the acetylcholine-induced contraction. Hirsutine showed a local anesthetic action in the isolated frog sciatic nerve preparation, while other alkaloids had only a weak effect. Hirsutine, isorhynchophylline, and gardnerine elevated the tone of the spontaneous movement of the organ and augmented its amplitude. The stimulating action of hirsutine was not affected by pretreatment with tetrodotoxin, atropine, diphenhydramine, or hexamethonium.
Core loss performance of a new PM machine topology for electric vehicles

The paper is concerned with the development of a core loss model for a variable flux machine using AlNiCo permanent magnets. A relationship between different magnetization levels and the machine core losses is derived experimentally. An analytical core loss model for non sinusoidal flux waveforms in the PM machine is presented. This model is based on an equivalent sinusoidal waveform. In this model, eddy current loss and hysteresis loss have been estimated based on Maxwell's equation. The analytical results from the proposed model are compared with finite element model (FEM) and experimental results.