Miracle-dz/UniFAR-FTUs huggingface dataset:
A prospective randomized evaluation of the TriGuard™ HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial.

AIMS To evaluate the safety, efficacy, and performance of the TriGuard™ HDH Embolic Deflection Device (TriGuard) compared with no cerebral protection in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS From February 2014 to March 2015, 85 subjects undergoing TAVI at 13 centres in Europe and Israel were randomized to TriGuard protection vs. no protection. Subjects underwent neurologic and cognitive evaluation at baseline, pre-discharge and 30 days; cerebral diffusion-weighted magnetic resonance imaging was performed at 4 ± 2 days post-procedure and at 30 days. Technical success, which included complete 3-vessel cerebral coverage, was achieved in 88.9% (40/45) of cases. The primary in-hospital procedural safety endpoint (death, stroke, life-threatening or disabling bleeding, stage 2 or 3 acute kidney injury, or major vascular complications) occurred in 21.7% of TriGuard and 30.8% of control subjects (P = 0.34). In the Per Treatment population (subjects with complete three-vessel cerebral coverage), TriGuard use was associated with greater freedom from new ischaemic brain lesions (26.9 vs. 11.5%), fewer new neurologic deficits detected by the National Institutes of Health Stroke Scale (3.1 vs. 15.4%), improved Montreal Cognitive Assessment (MoCA) scores, better performance on a delayed memory task (P = 0.028) at discharge, and a >2-fold increase in recovery of normal cognitive function (MoCA score >26) at 30 days. CONCLUSION TriGuard cerebral protection during TAVI is safe and complete cerebral vessel coverage was achieved in 89% of subjects. In this exploratory study, subjects undergoing protected TAVI had more freedom from ischaemic brain lesions, fewer neurologic deficits, and improved cognitive function in some domains at discharge and 30 days compared with controls.
Vasopressin increases milk flow and milk fat concentration in the goat.

AIM The aim of this study was to investigate whether physiological doses of vasopressin affect milk flow and milk composition in goats. METHODS Six goats were given vasopressin intravenously at doses of 0.1 ng kg(-1) min(-1) (a low dose, VL), 0.3 ng kg(-1) min(-1) (a medium dose, VM) and 1.0 ng kg(-1) min(-1) (a high dose, VH), oxytocin at 10 ng kg(-1) min(-1) and 0.15 m NaCl during 90 min at random. RESULTS Milk flow increased from 1.3 +/- 0.2 to 3.5 +/- 1.0 g min(-1) (VL), from 1.8 +/- 0.4 to 4.3 +/- 0.6 g min(-1) (VM) and from 1.5 +/- 0.2 to 7.9 +/- 0.9 g min(-1) (VH) during the first 30-min infusions (all P < 0.001), respectively, and then declined. The response to oxytocin corresponded to that of VH. Milk fat concentration increased from 2.1 +/- 0.1 to 3.3 +/- 0.4% during VH and from 2.8 +/- 0.6 to 4.1 +/- 0.6% during oxytocin (both P < 0.001), and tended to increase during VM and VL. The mammary blood flow of four goats was studied with ultrasound during VH and oxytocin infusion. Milk flow increased from 1.8 +/- 0.4 to 4.7 +/- 1.0 g min(-1) during VH and from 1.9 +/- 0.3 to 12.4 +/- 2.4 g min(-1) during oxytocin (both P < 0.001). Mammary blood flow decreased from 262 +/- 37 to 53 +/- 7 mL min(-1) (P < 0.001) during VH, but did not change during oxytocin. CONCLUSION We conclude that vasopressin increases milk flow and milk fat concentration and suggest that vasopressin, like oxytocin, acts on the myoepithelial cells.
The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter

Previously, we showed that the amphotropic receptor homolog in hamster cells functions as a receptor not only for amphotropic murine leukemia viruses and 10A1 murine leukemia virus but also for gibbon ape leukemia virus (C.A. Wilson, K. B. Farrell, and M. V. Eiden, J. Virol. 68:7697-7703, 1994). Here, we demonstrate that this receptor functions as a sodium-dependent Pi transporter and that Na-Pi uptake can be specifically blocked following infection with either amphotropic murine leukemia virus, 10A1 murine leukemia virus, or gibbon ape leukemia virus.
Linking abuse and recovery through advocacy: an observational study

Aims. High numbers of psychiatric service users experience domestic violence, yet limited interventions exist for these victims. We piloted a domestic violence intervention for community mental health services to explore the feasibility of a future cluster randomized controlled trial. Methods. Quasi-experimental controlled design within five Community Mental Health Teams (three intervention and two control teams). The intervention comprised domestic violence training for clinicians' and referral to domestic violence advocacy for service users. Clinicians' (n = 29) domestic violence knowledge, attitudes and behaviours were assessed before and 6 months post-training. Service users' (n = 34) safety behaviours, unmet needs, quality of life and frequency/severity of abuse were examined at baseline and 3 months follow-up. Process evaluation data were also collected. Results. Clinicians receiving the intervention reported significant improvements in domestic violence knowledge, attitudes and behaviours at follow-up (p < 0.05). Service users receiving the intervention reported significant reductions in violence (p < 0.001) and unmet needs at follow-up (p < 0.05). Conclusions. Interventions comprising domestic violence training for clinicians and referral to domestic violence advocacy may improve responses of psychiatric services. Low rates of identification among teams not receiving training suggest that future trials using service user outcomes are unlikely to be feasible. Therefore, other methods of evaluation are needed.
Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls

The pharmaceutical relevance of proton-coupled peptide transporters is currently under intense investigation in many laboratories. Studies have shown that these membrane proteins, expressed in intestine, kidney, choroid plexus and other tissues, accept many peptidomimetic drugs and prodrugs as substrates. The focus of this review is on the interaction of ß-lactam antibiotics, angiotensin-converting enzyme inhibitors, sartans and other drugs with PEPT1 and PEPT2. The article highlights progress made in recent years and the most expedient techniques that have been or are being employed. It also emphasizes the opportunities in rational drug design that are of highest priority and the pitfalls that must be avoided. Finally, an instructional flowchart that might be used to identify a peptide transporter substrate is proposed.
Social isolation, vital exhaustion, and incident heart failure: findings from the Atherosclerosis Risk in Communities Study

Prospective studies have shown that social isolation (i.e. lack of social contacts) predicts incident coronary heart disease (CHD), but it is unclear whether it predicts incident heart failure (HF) and what factors might mediate this association. HF patients may be more susceptible to social isolation as they tend to be older and may have disrupted social relationships due to life course factors (e.g. retirement or bereavement). We prospectively examined whether individuals with higher vs. low social isolation have a higher incidence of HF and determined whether this association is mediated by vital exhaustion.
Outsourcing with Heterogeneous Firms

A general framework for the study of outsourcing is introduced that incorporates dynamics and heterogeneity among both upstream and downstream producers to mimic an exit approach (Hirschman, 1970) to building vertical relations. The environment is one of search friction and incomplete contracts, where final-good producers require a specialized input and, upon matching with a supplier, can only contract the quantity of input. The results imply an assorted matching between producers and suppliers, so that more productive producers pair with more productive suppliers in the long run. It is shown that most efficient producers have some propensity to outsource, but only when there is a thick enough density of highly productive suppliers. Average employment in this model might increase or decrease with outsourcing, which is an observed pattern in the data. Some other diversities in plant-level behavior are also present in the results.
Impact of Use of Intramedullary and Extramedullary Guides on Tibial Component Geometry in Total Knee Replacements: A Systematic Review and Meta-Analysis

Abstract Mechanical guides in total knee arthroplasty are divided into intramedullary and extramedullary systems, designed to give accurate reference, to enable the surgeon to perform a tibial cut which is perpendicular to the mechanical axis. We conducted a systematic review and meta-analysis of levels 1 and 2 published data which directly compares the two methods of alignment, with outcomes of interest being the mean tibial component angle to the mechanical axis and the number of outliers from the optimal range. The PRISMA (preferred reporting items for systematic reviews and meta-analysis) guidance was followed. A search was conducted of online databases Medline PubMed; EMBASE; ISI Web of Science, and the Cochrane library, using the Boolean search string ([intramedullary OR extramedullary] AND knee AND [arthroplasty OR replacement]). Numerical data pertaining to tibial component alignment (TCA), the mechanical tibiofemoral angle, the tibial slope, and the number of outliers from optimal TCA were collated, and used to establish pooled results. No constraints on the search in terms of year of publication or language were instituted. Intrastudy bias was assessed using the Jadad score for randomized controlled trials and the Newcastle Ottawa score for prospective cohort studies. A total of 1,896 titles were reviewed. Following abstract review and full review of relevant articles, 10 publications were included for analysis, of which 8 were suitable to include for meta-analysis. No trials showed a significant difference in the mean TCA. Two trials showed an increased number of outliers in the extramedullary group and two studies showed an increased number of outliers in the intramedullary group. Pooled data from studies which included these outcomes showed no advantage for either system in limiting the number of outliers from the optimal TCA (relative risk, 0.99; 95% confidence interval [CI], 0.87–1.14; p = 0.004), and no significant difference in mean TCA (standardized mean difference, −0.07; 95% CI, −0.22 to 0.08; p = 0.000). Based on our results, no advantage can be attributed to the type of mechanical guide used in obtaining an adequate tibial cut.
A Low-Voltage Low-Power K-Band CMOS LNA Using DC-Current-Path Split Technology

A low-voltage low-power K-band low-noise amplifier (LNA) using 0.18 μm CMOS technology is presented in this letter. By splitting the dc current paths, the supply voltage of the LNA is effectively reduced. Moreover, the forward-biased body is adopted for the LNA to boost the gain. Furthermore, the high-value resistors are utilized between nMOS bodies and forward-body biases (VB) to prevent the signal leakage and noise coupling. The proposed LNA achieved a 13.2 dB gain and 4.1 dB noise figure at 20.5 GHz. The supply voltage and total dc power consumption are 0.6 V and 7.1 mW, respectively. To the author's knowledge, this LNA demonstrates the lowest supply voltage among previously published K-band 0.18 μm CMOS LNA.
Aperture coupled Wide-Band Micro Strip Antenna Design

Microstrip patch antennas are well suited for integration in to many applications owing to their conformal nature. There are many wide banding techniques used for the MSAs. But many wide banding techniques such as using slots in the patch require an inductive coupled feed (probe feed). But complete planar (2D) processes for manufacturability needs capacitive coupling. Capacitive coupling with coplanar feed network has the drawback that the feed network interferes with the radiation properties of the antenna. So the coupling techniques with the feed lines in the plane other then the antenna are more suitable. Aperture coupled feed and proximity feed are to such feed techniques. Of these, aperture coupled feed which makes use of thick antenna substrates is the most convenient as it has only single ground plane. Apart from this aperture coupling provides a greater radiation pattern symmetry and greater ease of design for higher impedance band width owing to a large number of design parameters. In this type of feed by using multiple patches bandwidths up to 70% are reported(how ever only single patch design is attempted in this project). So the parametric study, design, fabrication and testing of a with wide band aperture coupled antenna has been attempted in this project. And an aperture coupled antenna with 500 MHz band width was designed at 2GHz range thus realizing 25% band width. Band width considerations: In this project, 10 dB return loss band width is considered for design. The 10dB return loss corresponds to a VSWR of 2. Therefore the impedance circle for the antenna has to stay with in the VSWR =2 circle on the smith chart for the desired range of frequencies. So, the entire design problem thus boils down to identify the parameters of the ACMA geometry which control the impedance circle and tune the design parameters accordingly.
THE RELATIONSHIP OF EDUCATIONAL SUPERVISION AND GUIDANCE OF PRINCIPALS WITH ACADEMIC ACHIEVEMENT OF STUDENTS IN THE FIRST-GRADE HIGH SCHOOLS IN ROBAT KARIM , IRAN

The present study aimed to investigate the relationship of educational supervision and guidance of principals with academic achievement of students in the first-grade high schools in Robat Karim using correlation coefficient. The statistical population consisted of 58 male and female principals in the firstgrade high schools in Robat Karim among which 48 principals were selected using H. S. Bola Table with simple random sampling method. A researcher-made questionnaire was used to collect data on educational supervision and guidance. Reliability of the questionnaire was obtained as 87% through Cronbach's alpha coefficient. Pearson correlation test was used to analyze the data. Pearson correlation test results showed that educational supervision and guidance of principals and their components had significant effects on academic achievement of student. The correlation coefficient was obtained as 0.574, which showed a direct and strong correlation between the variables. In other words, the greater the educational supervision and guidance of principals, the higher the academic achievement of students in the first-grade high schools in Robat Karim.
Researching Young Children's Everyday Uses of Technology in the Family Home

Studies of the everyday uses of technology in family homes have tended to overlook the role of children and, in particular, young children. A study that was framed by an ecocultural approach focusing on children’s play and learning with toys and technologies is used to illustrate some of the methodological challenges of conducting research with young children in the home. This theoretical framework enabled us to identify and develop a range of methods that illuminated the home’s unique mix of inhabitants, learning opportunities and resources and to investigate parents’ethnotheories, or cultural beliefs, that gave rise to the complex of practices, values and attitudes and their intersections with technology and support for learning in the home. This resulted in a better understanding of the role of technology in the lives of these 3- and 4-year-old children.
Survival of rat embryos after freezing and thawing.

Survival of mammalian embryos after storage at sub-zero temperatures was first achieved in the mouse in which all the preimplantation stages were shown to survive storage at \m=-\196\s=deg\C when suitably cooled and thawed (Whittingham, Leibo & Mazur, 1972; Wilmut, 1972; Whittingham, 1974a). Similar procedures have demonstrated that blastocysts of cattle (Wilmut & Rowson, 1973), morulae and blastocysts of sheep (Willadsen, Polge, Rowson & Moor, 1974) and four-cell, eight-cell and morulae of rabbits (Bank & Maurer, 1973; Whittingham & Adams, 1974) will survive storage at \m=-\ 196\s=deg\C.This communica-tion reports the survival of two-cell, four-cell and eight-cell rat embryos after storage at \m=-\ 196\s=deg\Cfor periods up to 3 months.
Selective Activation of Fyn/PI3K and p38 MAPK Regulates IL-4 Production in BMMC under Nontoxic Stress Condition1

Mast cells have the ability to react to multiple stimuli, implicating these cells in many immune responses. Specific signals from the microenvironment in which mast cells reside can activate different molecular events that govern distinct mast cells responses. We previously demonstrated that hydrogen peroxide (H2O2) promotes IL-4 and IL-6 mRNA production and potentates FcεRI-induced cytokine release in rat basophilic leukemia RBL-2H3 cells. To further evaluate the effect of an oxidative microenvironment (which is physiologically present in an inflammatory site) on mast cell function and the molecular events responsible for mast cell cytokine production in this environment, we analyzed the effect of H2O2 treatment on IL-4 production in bone marrow-derived, cultured mast cells. Our findings show that nanomolar concentrations of H2O2 induce cytokine secretion and enhance IL-4 production upon FcεRI triggering. Oxidative stimulation activates a distinct signal transduction pathway that induces Fyn/PI3K/Akt activation and the selective phosphorylation of p38 MAP kinase. Moreover, H2O2 induces AP-1 and NFAT complexes that recognize the IL-4 promoter. The absence of Fyn and PI3K or the inhibition of p38 MAPK activity demonstrated that they are essential for H2O2-driven IL-4 production. These findings show that mast cells can respond to an oxidative microenvironment by initiating specific signals capable of eliciting a selective response. The findings also demonstrate the dominance of the Fyn/p38 MAPK pathway in driving IL-4 production.
Paraquat-induced lung injury: prevention by N-tert-butyl-alpha-phenylnitrone, a free-radical spin-trapping agent.

The herbicide paraquat causes lung injury that is believed to be oxygen-radical mediated. To further characterize this injury and explore new methods of preventing it, we used the spin-trapping agent N-tert-butyl-alpha-phenylnitrone (PBN) to identify the paraquat radical in lung tissue and to reduce the injury resulting from the subsequent generation of reactive oxygen species. The formation of a paraquat free radical by guinea pig lung was detected under anaerobic conditions by electron paramagnetic resonance spectrometry. Infused (25, 50, or 100 mg/kg) into guinea pig lungs (perfused at constant flow with Krebs solution containing 4% bovine serum albumin and ventilated with 95% O2-5% CO2), paraquat produced dose-dependent increases in peak airway pressure (Paw), mean pulmonary arterial perfusion pressure (Ppa), and wet-to-dry (W/D) lung weight ratio. At 100 mg/kg, paraquat increased Paw by 589.6 +/- 59.8% (mean +/- SE, n = 8) and W/D ratio from 5.33 +/- 0.07 to 6.29 +/- 0.11 (P less than 0.001). Pulmonary vascular leak index increased from 0.40 +/- 0.09 to 1.96 +/- 0.45 (P less than 0.02), without changes in pulmonary microvascular pressure. Perfusate concentrations of thromboxane B2 and 6-ketoprostaglandin F1 alpha increased, but indomethacin did not reduce the injury. PBN (2.3 mM) markedly attenuated all evidence of lung injury, which was also reduced by catalase, mannitol, ethanol, and vitamin E. (ABSTRACT TRUNCATED AT 250 WORDS)
Perception of risk in track and field venue management: are hammer facilities overlooked?

– The purpose of this paper is to determine the level of compliance with National Collegiate Athletic Association (NCAA) and International Association of Athletics Federations (IAAF) Track and Field Hammer Facility Recommendations at Division I universities in the USA, and to determine factors related to perceptions of facility safety. , – A 35‐item survey instrument was distributed to 279 applicable schools with a 28 percent response rate. Multiple regression analysis was utilized to determine factors significantly related to overall perception of safety. , – A total of 78.1 percent participants in the study report compliance with the NCAA minimum recommendations and 38 percent also meet the IAAF standards. Analysis of the perceived safety reported by coaches reveal a significant prediction equation. Further analyses reveal significant risk involving some current facilities guidelines. , – The NCAA may need to examine their present hammer facility guidelines and consider alignment with the new standards of the IAAF. , – The paper creates a new application of statistical analyses for risk perception in a specific sport setting.
Effective size and F-statistics of subdivided populations for sex-linked loci.

For a population subdivided into an arbitrary number (s) of subpopulations, each consisting of different numbers of separate sexes, with arbitrary distributions of family size and variable migration rates by males (dm) and females (df), the recurrence equations for inbreeding coefficient and coancestry between individuals within and among subpopulations for a sex-linked locus are derived and the corresponding expressions for asymptotic effective size are obtained by solving the recurrence equations. The usual assumptions are made which are stable population size and structure, discrete generations, the island migration model, and without mutation and selection. The results show that population structure has an important effect on the inbreeding coefficients in any generation, asymptotic effective size, and F-statistics. Gene exchange among subpopulations inhibits inbreeding in initial generations but increases inbreeding in later generations. The larger the migration rate, the greater the final inbreeding coefficients and the smaller the effective size. Thus if the inbreeding coefficient is to be restricted to a specific value within a given number of generations, the appropriate population structure (the values of s, dm, and df) can be obtained by using the recurrence equations. It is shown that the greater the extent of subdivision (large s, small dm and df), the larger the effective size. For a given subdivided population, the effective size for a sex-linked locus may be larger or smaller than that for an autosomal locus, depending on the sex ratio, variance and covariance of family size, and the extend of subdivision. For the special case of a single unsubdivided population, our recurrence equations for inbreeding coefficient and coancestry and formulas for effective size reduce to the simple expressions derived by previous authors.
Instantaneous Active and Reactive Power and Current Strategies for Current harmonics cancellation in 3-ph 4wire SHAF With both PI and Fuzzy Controllers

Control strategies for extracting the three-phase reference currents for shunt active power filters are compared, evaluating their performance under different source conditions with PI and Fuzzy Controllers in MATLAB/Simulink environment When the supply voltages are balanced and sinusoidal, the two control strategies are converge to the same compensation characteristics; However, the supply voltages are distorted and/or un-balanced sinusoidal, these control strategies result in different degrees of compensation in harmonics. The compensation capabilities are not equivalent, with p - q control strategy unable to yield an adequate solution when source voltages are not ideal. Extensive simulations are carried out with PI controller and also with Fuzzy controller for both p-q and Id-Iq control strategies under different main voltages. Extensive Simulations are carried out with PI as well as fuzzy controller for both p-q and Id - Iq control strategies by considering different voltage conditions and adequate results were presented. On owing Id - Iq method with fuzzy logic controller gives away an out-standing performance under any voltage conditions (balanced, un-balanced, balanced and non-sinusoidal).