Miracle-dz/UniFAR-FTUs huggingface dataset:
L G ] 2 1 M ay 2 01 8 Online Learning in Kernelized Markov Decision Processes

We consider online learning for minimizing regret in unknown, episodic Markov decision processes (MDPs) with continuous states and actions. We develop variants of the UCRL and posterior sampling algorithms that employ nonparametric Gaussian process priors to generalize across the state and action spaces. When the transition and reward functions of the true MDP are either sampled from Gaussian process priors (fully Bayesian setting) or are members of the associated Reproducing Kernel Hilbert Spaces of functions induced by symmetric psd kernels (frequentist setting), we show that the algorithms enjoy sublinear regret bounds. The bounds are in terms of explicit structural parameters of the kernels, namely a novel generalization of the information gain metric from kernelized bandit, and highlight the influence of transition and reward function structure on the learning performance. Our results are applicable to multi-dimensional state and action spaces with composite kernel structures, and generalize results from the literature on kernelized bandits, and the adaptive control of parametric linear dynamical systems with quadratic costs.
Running title : Antihypertensive activity in Lima bean peptide fractions

Norma A Ciau-Solís, Juan J Acevedo-Fernández, David Betancur-Ancona Facultad de Ingeniería Química, Universidad Autónoma de Yucatán. Periférico Norte Km. 33.5, Tablaje Catastral 13615, Colonia Chuburná de Hidalgo Inn, 97203 Mérida, Yucatán, México. * E-mail: bancona@correo.uady. mx, Tel. +52 9999460956, Fax. +52 99994609942 2 Facultad de Medicina. Universidad Autónoma del Estado de Morelos, México.
THE TOOLS THAT CONTRIBUTE TO EXPAND THE RESECTABILITY OF PATIENTS WITH ADVANCED CLM Neoadjuvant Chemotherapy

Improvements in treatment strategies and a better knowledge of tumor biology have contributed to an increase in the number of patients with colorectal liver metastases (CLM) who are candidate for surgery. These progresses are on going and the introduction of effective systemic therapy agents contributes further to the increase in the resectability of patients with advanced CLM. J. Surg. Oncol. 2010;102:996–1001. 2010 Wiley-Liss, Inc.
Case Particle Errors in Japanese: Is the Nominative ga a Default Case Marker in Sentence Production?

This study examines experimentally induced case particle errors in Japanese. It was found that the nominative ga was the preferred particle for sentence-initial NPs and was the most frequently overused particle for argument NPs, providing some support to the claim that ga is a default marker. The study also shows that case particle error occurrence depends on verb type, suggesting the importance in future studies of experimentally controlling or manipulating the number of opportunities for speakers to produce NPs occurring with specific verb types.
Infundibulum Uterine tube Ovary Cervix Vagina Perimetrium Fimbriae Fundus Uterus

sev re /09 II. T he Uterus . 5 4 III. P rogesterone Action on the Endometrium and Myometrium . 5 6 A. P hysiological Response to Progesterone . 5 6 B. P rogesterone Receptors . 5 7 C. C oregulators of PR . 5 8 D. P rogesterone Receptors in the Endometrium and Myometrium. 6 0 IV. E ndometrial Cancer . 6 1 V. P rogesterone Receptor Action in Endometrial Cancer . 6 2 A. P rogestin Therapy in Women . 6 2 B. P rogesterone Receptors in Endometrial Cancer. 6 3 C. G enes Regulated by Progestins in Endometrial Cancer. 6 3 D. T ranscriptional Activity of Progesterone Receptors in Endometrial Cancer. 65 VI. C onclusions and Perspectives of Progesterone Action in Endometrial Cancer . 66 VII. U terine Leiomyoma. 6 6 V III. P rogesterone Receptor Action in Leiomyoma. 6 7 A. R elevance of Progesterone in Uterine Leiomyomas . 6 7 B. P rogesterone Action on Genes Associated with Proliferation, Apoptosis, and ECM Deposition . 68 C. G rowth Factor Regulation in Leiomyoma by Progesterone . 7 0 D. A ctivation of Signaling Pathways in Leiomyoma by Progesterone and Estrogen . 71 IX. C onclusions and Perspectives on Progesterone Action in Uterine Leiomyoma. 73 X. F uture Directions . 7 4 R eferences . 7 4
CREI Working Paper no. 3/2009 MARKET ACCESS, ORGANIC FARMING AND PRODUCTIVITY: THE DETERMINANTS OF CREATION OF ECONOMIC VALUE ON A SAMPLE OF FAIR

We analyse the impact of Fair Trade and organic farming on a sample of Fair Trade rice producers in Thailand. We find that per capita income from agriculture is positively and significantly affected by organic certification and FT affiliation years. This effect does not translate into higher productivity due to a concurring increase in worked hours. The estimated FT and organic certification contributions are however downward biased if we do not take into account the relatively higher share of selfconsumption of affiliated farmers. Our main findings are robust when we control for selection bias and endogeneity with instrumental variables, when using propensity score matching and restricting the sample to affiliated producers only. We also test which of the two (organic and FT) effects is stronger and find that the latter prevails.
New insight in the photoheterotrophic growth of the icl-purple bacterium

26 Purple non-sulfur bacteria are well known for their metabolic versatility. One of these bacteria, 27 Rhodospirillum rubrum S1H, has been selected by the European Space Agency (ESA) to ensure the 28 photoheterotrophic assimilation of volatile fatty acids (VFAs) in its regenerative life support system, 29 MELiSSA. Here, we combined proteomic analysis with bacterial growth analysis and enzymatic activity 30 assays in order to better understand acetate photoassimilation. In this isocitrate lyase lacking organism 31 (icl), the assimilation of 2-carbon compounds cannot occur through the glyoxylate shunt, and the 32 citramalate cycle has been proposed to fill this role while, in Rhodobacter sphaeroides, the ethylmalonyl33 CoA pathway is used for acetate assimilation. Using proteomic analysis, we were able to identify and 34 quantify more than 1,700 unique proteins, representing almost one-half of the theoretical proteome of 35 the strain. Our data reveal that a pyruvate:ferredoxin oxidoreductase (NifJ) could be used for the direct 36 assimilation of acetyl-CoA through pyruvate, potentially representing a new redox balancing reaction. 37 We additionally propose that the ethylmalonyl-CoA pathway could also be involved in acetate 38 assimilation by the examined strain, since specific enzymes of this pathway were all up-regulated and 39 activity of crotonyl-CoA reductase/carboxylase was increased in acetate condition. Surprisingly, we also 40 observed marked up-regulation of glutaryl-CoA dehydrogenase, which could be a component of a new 41 pathway for acetate photoassimilation. Our data finally suggest that citramalate could be an 42 intermediate of the branched chain amino acid biosynthesis pathway which is activate during acetate 43 assimilation rather than a metabolite of the so-called citramalate cycle. 44
ditorial on in Japanese heart failure patients

Heart failure (HF) is a complex clinical syndrome, where not nly heart failure with preserved ejection fraction (HFpEF) but also eart failure with reduced EF (HFrEF) are substantially involved 1,2]. Indeed, HFpEF and HFrEF respectively account for approxmately half of HF patients [3,4]. Although it has been reported hat the prognosis is comparable between patients with HFpEF and hose with HFrEF [3,4], we also have previously demonstrated that he patients with HFpEF had a significantly better prognosis than hose with HFrEF; however, after the adjustment with stage of HF, he survival became comparable between the 2 groups, suggestng a smaller population of HFpEF in the advanced stage of HF [5]. his previous study also demonstrated that the 5-year survival rate rom all-cause death was apparently better than in the previous tudy [6], probably because the patients are monthly followed up o control sodium intake and blood pressure in Japan. Consistently, t has been also reported that intensive medical treatment for HF atients with close follow-up can reduce re-admission for HF and ardiac deaths [7]. In the current issue of Journal of Cardiology, Kaneko et al. dentified the clinical characteristics, long-term outcomes, and rognostic factors of HFpEF and HFrEF in a Japanese real-world linical practice [8]. The major findings were (1) that the prevaence of HFpEF was relatively high, (2) that patients with HFpEF howed a better prognosis than those with HFrEF; however, the linical outcomes of HFpEF and HFrEF patients were comparable n inpatients, and (3) that the independent predictors of all-cause eath were older age, chronic kidney disease (CKD), anemia, prior yocardial infarction, absence of statin treatment, and lower left entricular EF in HFrEF, and lower body mass index, CKD, anemia, igher B-type natriuretic peptide and left ventricular hypertrophy n HFpEF [8]. As also previously reported, patients with HFpEF are onsistently older, with a higher prevalence of females and hyperension, compared to those with HFrEF [4,6,9]. Furthermore, it has een also reported that the prognostic factors of HF are older age, everity of HF, anemia, presence of CKD, lower EF, and the presnce of pulmonary hypertension due to left heart disease [8,10–12]. ased on these observational findings, more effective treatment for F should be developed in the near future. The mechanism of interaction between HFpEF and HFrEF hould also be clarified in future studies. As previously reported, everal risk factors, such as metabolic disorders and hypertension,
The CD14 rs2569190 TT Genotype is Associated with Chronic Periodontitis.

AIM The genetic variation in the CD14 rs2569190 promoter region contributes to the susceptibility of developing periodontitis. Since, CD14 gene polymorphism studies among various ethnic populations have produced conflicting results, the present study was designed to unearth the association between the CD14 rs2569190 gene polymorphism and generalized chronic periodontitis (GCP) in a South Indian population of Tamil ethnicity. METHODS Polymorphisms in the CD14 rs2569190 promoter region were analyzed in 96 subjects who were periodontally healthy and 96 patients with GCP. DNA extracted from peripheral venous blood was genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis. One-way analysis of variance, Chi-square testing, and logistic regression analysis were used to test association between GCP and the CD14 rs2569190 single nucleotide polymorphism (SNP). RESULTS The distribution of the CD14 rs2569190 genotypes and allele frequencies showed significant differences between the test and control groups. Prevalence of the polymorphic TT genotype and T allele of the CD14 rs2569190 were significantly increased in GCP patients when compared with healthy controls. CONCLUSION The results of the present study suggest that the T allele and the TT genotype of the rs2569190 SNP in the promoter region of the CD14 gene are associated with GCP in a South Indian population of Tamil ethnicity.
Conversation with the Experts Toward Optimal Health : Maternal Benefits of Breastfeeding

David Meyers, M.D., is Director of the Center for Primary Care, Prevention, and Clinical Partnerships at the Agency of Health Care Research and Quality. He has served as a medical officer with the U.S. Preventive Services Task Force and directed the Georgetown University Department of Family Medicine’s practice-based research network, CAPRICORN, while providing primary care, including maternity care, in a community health center in Washington, DC. Jodi R. Godfrey, M.S., R.D. , is a health and wellness specialist in private practice and a Contributing Editor to the Journal.
Yewdell Influenza Vaccination Outflanking Antibody Immunodominance on the Road to Universal Is It Possible to Develop a ' ' Universal ' ' Influenza Virus Vaccine ? :

Influenza remains a majorhumanpathogendespite seasonal vaccination. At long last, there is energyandresources todevelop influenzavaccinesthatprovidemorepredictableanddurable protection. Vaccines based on inducing antibodies to the conserved stem of the viral hemagglutinin (HA) have emerged as leading candidates for broadening population immunity and ultimately limiting antigenic drift. Here, we discuss the knowns and unknowns of HAspecific B-cell and antibody responses. In particular, we focus on how immunodominance sculpts antibody responses and drives antigenic drift. We propose a number of strategies to overcome immunodominance and improve the breadth and efficacy of antibody responses.
pathwaysin skeletal development through p 53-dependent intracellular signaling regulates survival and proliferation α PI 3 K-mediated PDGFR Material Supplemental

Material Supplemental http://genesdev.cshlp. org/content/suppl/2014/04/29/28.9. 1005.DC1. html References http://genesdev.cshlp. org/content/28/9/1005.full. html#ref-list-1 This article cites 52 articles, 28 of which can be accessed free at: License Commons Creative . http://creativecommons.org/licenses/by-nc/4.0/ at Creative Commons License (Attribution-NonCommercial 4.0 International), as described ). After six months, it is available under a http://genesdev.cshlp. org/site/misc/terms.xhtml six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first
domains barrier regions reveals demarcation of active and repressive Global analysis of the insulator binding protein CTCF in chromatin Material

Open Access Open Access option. Genome Research Freely available online through the License Commons Creative http://creativecommons.org/licenses/by-nc/3.0/. described at a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as ). After six months, it is available under http://genome.cshlp. org/site/misc/terms.xhtml first six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the
Forensic DNA Technological Advancements as an Emerging Perspective on Medico-Legal Autopsy: A Mini Review

The importance of biological traces and evidences related to a criminal matter has been recognized for a long time. The examination of the expression of genetic polymorphism has been an integral part of the multidisciplinary field of medico-legal autopsy for over a century. Since the initial application of blood group antigens for personalization of a putative perpetrator in a murder case, the discipline of forensic genetics has evolved as a standard of forensic sciences. The real breakthrough, the application of molecular tools and processes for the in-vitro replication of genetic substances, has increasingly allowed the exploitation of advances of molecular genetics for both forensic and criminal investigations. Although there are certainly many more applications and scientific fields in the medico-legal arena, the relatively fast progress of genetics, which has accelerated recently with state-of-art technologies, can provide ever more relevant information in relation to a corpse or the cause and manner that resulted in the corpse for autopsy. This topic concerns the currently accepted forensic DNA technology, and the last section reviews commonly used markers for nuclear and mitochondrial DNA analysis as well as ongoing research. This review also focuses on the increasingly important non-human sources of DNA, and shortly covers the main aspects of animal forensic DNA examination.
to rapid tRNA decay by high-throughput in vivo analysis Identification of the determinants of tRNA function and susceptibility Material

Material Supplemental http://genesdev.cshlp. org/content/suppl/2014/07/31/28.15. 1721.DC1. html References http://genesdev.cshlp. org/content/28/15/1721.full. html#ref-list-1 This article cites 61 articles, 32 of which can be accessed free at: License Commons Creative . http://creativecommons.org/licenses/by-nc/4.0/ at Creative Commons License (Attribution-NonCommercial 4.0 International), as described ). After six months, it is available under a http://genesdev.cshlp. org/site/misc/terms.xhtml six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first
Joint Action of the Nano-sized System of Small Non-coding RNAs with DDMC Vector and Recombinant IL-7 Reprograms A-549 Lung Adenocarcinoma Cells into CD4 + Cells

Small non-coding RNAs, as class of small regulatory molecules, control normal development and differentiation of cells. Micro-RNAs and piwi-interacting-RNAs are members of epigenetic regulators family. In previous studies researches investigated the role of different small non-coding RNAs in pathophysiology of cancer. Objective: In this study A-549 lung adenocarcinoma cells were firstly epigenetically reprogrammed and transformed into CD4+ cells. Method: I used new non-viral carrier the complex of DDMC vector with antago-miR-155 and piR-30074 for long-lasting transfection of lung cancer cells. Results: The transformation of A-549 lung cancer cells was proved by morphological and genetic changes (AltAnalyze Platform) in dynamics. I observed CD4+ lymphocytes phenotypic marker and OCT4 marker of pluripotent cells by immunofluorescence microscopy in transformed cells.
PNS1100052 351..364

Nutrition refers to the process by which a living organism ingests and digests food and uses the nutrients therein for growth, tissue maintenance and all other functions essential to life. Food components interact with our body at molecular, cellular, organ and system level. Nutrients come in complex mixtures, in which the presence and concentration of single compounds as well as their interactions with other compounds and the food matrix influence their bioavailability and bioefficacy. Traditionally, nutrition research mainly concentrated on supplying nutrients of quality to nourish populations and on preventing specific nutrient deficiencies. More recently, it investigates health-related aspects of individual ingredients or of complete diets, in view of health promotion, performance optimisation, disease prevention and risk assessment. This review focuses on proteins and peptides, their role as nutrients and biomarkers and on the technologies developed for their analysis. In the first part of this review, we provide insights into the way proteins are currently characterised and analysed using classical and emerging proteomic approaches. The scope of the second part is to review major applications of proteomics to nutrition, from characterisation of food proteins and peptides, via investigation of health-related food benefits to understanding disease-related mechanisms.
What are the implications of this new knowledge for nursing care with older people ?

Aim and objective. To identify the influence of the culture in Canadian long-term care facilities on the awareness of impending death and initiation of a palliative approach to care for residents aged 85 years and older. Background. Many long-term care residents die after long, dwindling dying trajectories, yet palliative care is often not provided until within a few hours or days of death. Design. Focused ethnography. Methods. Data were collected in three long-term care facilities in south-central Ontario, Canada, through interviews with residents, family members and staff members, observation, artefact review and a focus group. Data were analysed using a constant comparative technique. Results. Four cultural influences on the awareness of impending death and consequent initiation of a palliative approach to care were identified: (i) the care demands in long-term care facilities and the resources available to meet these demands; (ii) the belief that long-term care facilities are for living; (iii) the belief that no one should die in pain; and (iv) the belief that no one should die alone. Conclusions. Commonly held beliefs about the role of long-term care facilities and what is viewed as acceptable care in them mediated the acknowledgement of dying. Late initiation of palliative care was the consequence. In addition, the contextual factors of a low staff-to-resident ratio and reduced staff preparation for palliative care were also influential for a delayed response to dying. Implications for practice. Because strongly held long-term care cultural beliefs underlie care, more timely palliative care for long-term care residents is likely to require the development of an understanding that living and dying are not dichotomous, but rather unfold together from admission until death. Enhanced staff-to-resident ratios and staff training on palliative care will also be necessary to permit long-term care facility staff to focus beyond the currently expected dayto-day care of living residents to provide high-quality end-of-life care throughout the often protracted decline to death for residents of long-term care facilities.
Cardiac Output in Cardiac Surge Ability of the Third-Generation FloTrac / Vigileo Software to Track Changes in ry Patients : A Polar Plot Approach

Objective: To evaluate the ability of the third-generation (3.01) of FloTrac/Vigileo monitor (Edwards Lifesciences, Irvine, CA) to follow variations in cardiac output (ΔCO) using the new polar plot approach. Design: Prospective interventional study. Setting: Single hospital university study. Participants: Twenty-five patients referred for cardiac surgery. Interventions: CO was measured simultaneously by 3 to 5 bolus thermodilution (COtd measurements), using a pulmonary artery catheter and by arterial pulse contour analysis, using the FloTrac/Vigileo (COvi). Data were collected at eight time points: before incision, after sternotomy, before and after protamine sulfate infusion, at the start of sternal closure, at the end of surgery, on arrival to intensive care unit, and after a standardized volume expansion with 500 mL of hetastarch 6%. Measurements and Main Results: One-hundred thirty-five pairs of CO data were collected; the mean bias of all CO
Effects of Transfusion of Resid Outcomes and Biochemical Parameters Following Cardiac Surgery : ual Blood Using Centrifugation and Multiple-Pass Hemoconcentration

Objectives: To determine whether or not there was a significant difference between the methods of centrifugation (CF) and multiple-pass hemoconcentration (MPH) of the residual cardiopulmonary-bypass volume in relation to biochemical measurements and patient outcomes. Design: Prospective, randomized, and controlled. Setting: Conducted at a western Canadian tertiary care hospital. Participants: Consisted of 61 consecutive male and female patients from ages 40 to 80 who were scheduled for cardiac surgery with cardiopulmonary bypass. Interventions: Either the centrifugation or multiple-pass hemoconcentration method was used to process the residual blood from the cardiopulmonary bypass circuit. Results: The 12-hour postoperative levels of serum hemoglobin were not significantly different in the centrifugation group as compared to the multiple-pass hemoconcentration group. However, the serum levels of total protein and albumin were significantly higher in the multiple-pass