Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of antioxidative activity of extract from fermented grain food mixture using chemical and cellular systems

Fermented food is a rich source of antioxidants and micronutrients with the potential to prevent various human diseases. The increasing evidence indicates that in addition to its direct action, radical‐scavenging antioxidants may modulate the cellular antioxidant system such as glutathione. In the present study, we investigated the antioxidant activity of Antioxidant Biofactor (AOBTM ) extracts, a mixture of commercially available fermented grain food by using chemical and cellular experimental systems. In the former system, the total radical scavenging capacity was assessed from the bleaching of pyranine and pyrogallol red that is induced by free radicals generated from an azo initiator. In this assay system, the radical scavenging capacity per gram of AOB was estimated to be 95 μmol. On the other hand, the cytoprotective effect of AOB was also investigated on the basis of PC12 cell death induced by 6‐hydroxydopamine. In this cellular system, AOB extract exhibited a cytoprotective effect only when the cells were pretreated with AOB. This pretreatment resulted in a significant increase in the levels of cellular glutathione as well as regulator of glutathione synthesis, such as the cystine/glutamate exchange transport system (xCT). This evidence suggests that AOB possesses both direct and indirect antioxidant activities to cope with oxidative insults.
Adjunctive plasma exchanges to treat neuropsychiatric lupus: a retrospective study on 10 patients

Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) are among the main causes of morbidity and mortality attributed to lupus activity. Conventional NPSLE treatment combines CS and immunosuppressants, but some symptoms do not respond. We retrospectively evaluated the adjunction of plasma exchanges (PE) to treat 13 NPSLE flares occurring in 10 patients (mean age, 30 years) between 1989 and 2002. NP manifestations were the first SLE symptoms for seven patients, with a mean of 3.2 NP manifestations/flare. All patients received CS and cyclophosphamide pulses. A mean of 15 PE/flare were performed. All patients improved within a mean of 3 (median: 2.5; range: 1.5—8) weeks thereafter. Complete remissions of 7/13 flares were obtained within a mean of 7 (median: 4; range: 2—22) weeks. Partial remissions were achieved for the remaining six flares, characterized by new NP manifestations during three and insufficient control of the others. Other SLE manifestations regressed for all patients with the mean European consensus lupus activity measurement score declining from pretreatment 6.9 to 1.2. A regimen combining CS, cyclophosphamide and PE is effective against severe NPSLE, with acceptable toxicity. Lupus (2007) 16, 817—822.
Journalistic Translation in the Selected Czech Press

Tato prace si klade za cil přispět k lepsimu porozuměni žurnalistickeho překladu ze dvou různých hledisek – jednak jako druhu neliterarniho překladu a jednak jako produktu se zaměřenim na překlady v tistěných mediich. V casti věnovane žurnalistickemu překladu jako druhu neliterarniho překladu je sestaven komplexnějsi obraz tohoto typu překladu v ramci zkoumani jeho nazvu, rozsahu, hlavnich oblasti zajmu a v neposledni řadě take hlavnich rysů. Při sestavovani uceleneho přehledu hlavnich rysů a klicových oblasti prace cerpa z různých zjistěni a zavěrů, ktere byly v tomto oboru dosud provedeny. Tento poněkud teoreticky zaměřený ramec prace je posleze doplněn o přehled těch překladových teorii a přistupů, ktere se zdaji být pro zkoumani žurnalistickeho překladu klicovými. V dalsi casti prace se autor dostava ke zkoumani žurnalistickeho překladu jako produktu. Za timto ucelem je provedena analýza překladů, ktere byly cerpany ze tři periodik – Hospodařských novin, Respektu a Ekonomu. Je třeba zminit, že se jedna se o překlady z anglictiny do cestiny. V teto casti je pozornost zaměřena předevsim na zkoumani globalnich a lokalnich překladových strategii.
New Pseudo-Random Number Generator System Based on Jacobian Elliptic maps and Standard Map

Chaotic systems have numerous properties, for example: mixing property, sensitivity to initial conditions parameters, structural complexity and deterministic dynamics. These properties were investment in the last decade for cryptographic applications and developments of pseudorandom number/bit generator. The paper propose new pseudorandom number (bits) generator (PRNG) based on the Jacobian elliptic chaotic maps and standard map. The principle of the method consists in generating binary sequence from elliptic chaotic maps of cn and sn types. These sequence positions is permuted using standard map. The performance of the generator is studied through conventional statistical methods and also using the NIST test suite. The results show that the produced sequences possess high randomness statistical properties and good security level which make it suitable for cryptographic applications.
Interferon Production in Cell Lines Derived from Patients with Infectious Mononucleosis

Discussion and Summary In a previous report, it has been shown that biopsy material from patients with Burkitt's lymphoma gave rise to continuous cell lines in vitro (4,5). The lines appear to be lymphoid in character, produce interferon, contain a herpes-like virus (6,7) and synthesize immunoglobulins (8). In studying the peripheral leukocytes from patients with heterophile positive acute infectious mononucleosis, we have successfully isolated continuous cell lines in vitro. These lines possess the biological features of continous Burkitt cell lines (1). In these studies an inhibitor present in the established cell suspensions was identified as interferon on the basis of criteria used for the classification of interferons. Recently it has been reported that lymphoblastoid cells derived from fibroblastic elements of bone marrow of patients with infectious mononucleosis produced interferon (9). Although the inducer of interferon synthesis has not been identified, preliminary electron microscopy data in our laboratory indicates the presence of unusual 22 mμ particles in all of the cell lines studied for antiviral activity (10).
Maximum crosstalk in a transmission line system with linear time-invariant terminal networks

The authors analyze the crosstalk in the case of a coupled transmission line system with linear time-invariant terminal networks. They present techniques for computing the maximum possible value for crosstalk that can take place at a certain line and find the pattern of the input excitations and the relative delays for which the maximum occurs. For the case of lossless transmission lines, a procedure is outlined for finding the length of the lines above which the maximum crosstalk at the load end is constant. <<ETX>>
Preparation of DNA-Functionalised CdSe/ZnS Quantum Dots

: We functionalised core-shell CdSe/ZnS quantum dots (QDots) with short-chain 3-mercaptopropionic acid (3MPA) to render these nanocrystalline semiconductor water-soluble. The ligand-exchange reaction was significantly improved with the use of an organic base to first remove the thiolic hydrogen. Non-bound 3MPA could be removed from the colloid by dialysis, but it was found that the choice of membrane is important. Cellulose membrane obliterated the photoluminescence of the QDots, while cellulose-acetate membrane worked well. Amine-modified DNA was then attached to the QDots through amide bond linkage, using EDC and NHS as reaction promoters. The pH of the reaction medium has an important impact on the successful attachment of functional DNA on the QDots.
Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections

ABSTRACT Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.
The geology of 433 Eros

Abstract— The global high‐resolution imaging of asteroid 433 Eros by the Near‐Earth Asteroid Rendezvous (NEAR) Shoemaker spacecraft has made it possible to develop the first comprehensive picture of the geology of a small S‐type asteroid. Eros displays a variety of surface features, and evidence of a substantial regolith. Large scale facets, grooves, and ridges indicate the presence of at least one global planar structure. Directional and superposition relations of smaller structural features suggest that fracturing has occurred throughout the object. As with other small objects, impact craters dominate the overall shape as well as the small‐scale topography of Eros. Depth/diameter ratios of craters on Eros average ∼0.13, but the freshest craters approach lunar values of ∼0.2. Ejecta block production from craters is highly variable; the majority of large blocks appear to have originated from one 7.6 km crater (Shoemaker). The interior morphology of craters does not reveal the influence of discrete mechanical boundaries at depth in the manner of craters formed on lunar mare regolith and on some parts of Phobos. This lack of mechanical boundaries, and the abundant evidence of regolith in nearly every high‐resolution image, suggests a gradation in the porosity and fracturing with depth. The density of small craters is deficient at sizes below ∼200 m relative to predicted slopes of empirical saturation. This characteristic, which is also found on parts of Phobos and lunar highland areas, probably results from the efficient obliteration of small craters on a body with significant topographic slopes and a thick regolith. Eros displays a variety of regolith features, such as debris aprons, fine‐grained “ponded” deposits, talus cones, and bright and dark streamers on steep slopes indicative of efficient downslope movement of regolith. These processes serve to mix materials in the upper loose fragmental portion of the asteroid (regolith). In the instance of “ponded” materials and crater wall deposits, there is evidence of processes that segregate finer materials into discrete deposits. The NEAR observations have shown us that surface processes on small asteroids can be very complex and result in a wide variety of morphologic features and landforms that today seem exotic. Future missions to comets and asteroids will surely reveal still as yet unseen processes as well as give context to those discovered by the NEAR Shoemaker spacecraft.
Carbon Fluxes in Plant-Soil Systems at Elevated Atmospheric CO2 Levels.

The flow of carbon from photosynthesizing tissues of higher plants, through the roots and into the soil is one of the key processes in terrestrial ecosystems. An increased level of CO2 in the atmosphere will likely result in an increased input of organic carbon into the soil due to the expected increase in primary production. Whether this will lead to accumulation of greater amounts of organic carbon in soil depends on the flow of carbon through the plant into the soil and its subsequent transformation in the soil by microorganisms. In this paper the major controls of carbon translocation via roots into the soil as well as the subsequent microbial turnover of root-derived carbon are reviewed. We discuss possible consequences of an increased CO2 level in the atmosphere on these processes.
Direct tests for solar-neutrino mass, mixing, and Majorana magnetic moment.

The present data on solar neutrinos may suggest matter effects resulting in (i) flavor conversion (Mikheyev-Smirnov-Wolfenstein effect) due to a nonzero neutrino mass and/or mixing and (ii) spin-flavor conversion due to a Majorana magnetic moment. Both possibilities can be explicitly tested in upcoming experiments (i) via the effect of Earth matter on {sup 7}Be neutrinos and (ii) by the detection of {sup 8}B {ital antineutrinos} during solar activity.
Topoisomerase Action on Short DNA Duplexes Reveals Requirements for Gate and Transfer DNA Segments*

Type II topoisomerases change DNA topology by passage of one DNA duplex (the transfer, T-segment) through a transient double-stranded break in another (the gate, G-segment). Here we monitor the passage between short double-stranded DNA segments within long single-stranded DNA circles that leads to catenation of the circles. To facilitate catenation, the circles were brought into close proximity using a tethering oligonucleotide, which was removed after the reaction was complete. We varied the length and the composition of the reacting DNA segments. The minimal DNA duplex length at which we detected catenation was 50–60 bp for DNA gyrase and 40 bp for topoisomerase IV (Topo IV). For Topo IV, catenation was observed when one, but not both, of the DNA-DNA duplexes was replaced by a DNA-RNA duplex. Topo IV cleaved the DNA-DNA duplex, but not the DNA-RNA duplex implying that the DNA-RNA duplex can be a T-segment but not a G-segment.
Molecular biology, pathogenesis and pathology of mumps virus

Mumps is caused by the mumps virus (MuV), a member of the Paramyxoviridae family of enveloped, non‐segmented, negative‐sense RNA viruses. Mumps is characterized by painful inflammatory symptoms, such as parotitis and orchitis. The virus is highly neurotropic, with laboratory evidence of central nervous system (CNS) infection in approximately half of cases. Symptomatic CNS infection occurs less frequently; nonetheless, prior to the introduction of routine vaccination, MuV was a leading cause of aseptic meningitis and viral encephalitis in many developed countries. Despite being one of the oldest recognized diseases, with a worldwide distribution, surprisingly little attention has been given to its study. Cases of aseptic meningitis associated with some vaccine strains and a global resurgence of cases, including in highly vaccinated populations, has renewed interest in the virus, particularly in its pathogenesis and the need for development of clinically relevant models of disease. In this review we summarize the current state of knowledge on the virus, its pathogenesis and its clinical and pathological outcomes. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
A Relationship Model for Believable Social Dynamics of Characters in Games

This dissertation investigates believable social dynamics based on a relationship model between Non-Player Characters (NPCs) in games. The majority of interactions between characters in games is rigidly defined; with limited scope for character relationships that change as a result of interactions with each other or other factors. This limited ability hinders player immersion and believability in their interactions with the characters. This dissertation presents a model which can be easily applied to NPCs to provide them with relationship awareness. The model supports characters that store their own "assumed knowledge" of other characters relationships, in addition to their own direct relationships with other characters in their environment. This allows the characters awareness of not just their own relationships to other characters (e.g. to a sibling or child character), but also awareness of the relationships between other characters (e.g. that two other characters may be enemies). This knowledge can be treated as an assumption; allowing characters to be provided with misleading information - the results of which are left up to extended implementations of the model. A messaging system is also implemented that allows the characters to communicate with one another directly as well as through their relationships (e.g. passing a message to all members of a group). The model has been implemented with a generic interface that allows other types of information to be tracked between NPCs as extensions to the basic relationships between characters. This provides for advanced implementations such as characters that "remember" previous relationship states with other NPCs. The model is tested and evaluated within a prototype environment within the Unity game engine. The implementation showcases a model with promising potential where characters act upon, learn and communicate about relationships they are aware of.
Unlocking Value Creation Using an Agritourism Business Model

Agritourism has achieved a greater importance in the last decade, but despite this relevance, the definition is not aligned everywhere, depending on the contingency variables of the context in which agritourism is located. This paper aims at analyzing the business model’s key success factors of Italian agritourism by studying their structural, social and economic features, integrated with a sustainability approach. The empirical analysis is based on a sample of agritourism, located in an Italian region. The empirical results show relevant and useful elements to support the sustainable development of agritourism business models in Italy, linking theory, policy and practices. Indeed, these results, together with others related to the economic dimension of the farms, their specialization, and the characteristics of the farmers make it possible to argue that there are common elements, which offer potential for agritourism. In addition, it was possible to identify two different models of agritourism. Agritourism can open new horizons in rural sustainable development, with possible beneficial effects on the environment, society, agricultural heritage and economic growth. In particular, regional policy developers should take into consideration these elements in order to direct correctly efforts. The research shows also some interesting theoretical implications as it contributes to enrich the literature on this particular kind of business model. At the same time, it helps family owners to increase the overall understanding of their agritourism, in order to finalize adequate planning and communication.
A new approach to R&D evaluation

An R&D evaluation method is described. Its development was conditioned by an earlier review of other methods and by certain local requirements. Although referencing a chemical-business system, the concept, and much of the procedure, can be applied to other R&D fields. Four separate and fairly simple computer programs are involved. The first three concern capital and operating cost (or income) estimates for a future commercial venture. The fourth program executes discounted cash flow (DCF) calculations over specific cash flow frameworks. Relationships between the commercial venture and the R&D required are briefly discussed; also, the importance of involving the marketing group in establishing, or verifying, relevant sales forecasts, etc. Overall, the method described offers a reasonably practical approach to the R&D evaluation problem. It is urged that evaluations of this kind be made at all stages of R&D progress.
A novel design method for asynchronous bundled-data transfer circuits considering characteristics of delay variations

As the VLSI technology advances, delay variations become extremely large. Delay variation properties caused by various variation factors are different. However, the characteristics of delay variations have not been considered in traditional delay models or asynchronous design styles, which have, therefore, suffered large performance overhead. In this paper, we propose the following two methods for designing high performance asynchronous bundled-data transfer circuits based on the scalable-delay-insensitive model: 1) a variation-aware delay cell library which consists of delay cells exhibiting a wide variety of delay variation characteristics for combinational circuits; and 2) a selectable delay line in which we can select an appropriate delay line in accordance with dynamic voltage changes. Then, we show some evaluation results for the variation factor K which represents the margin that guarantees the correct operations. As a result, the performance overhead can be reduced more than 30 percent compared to conventional bundled-data transfer circuits
Age and cognitive functions as intelligence predictors

Aging-induced changes in relationships between intelligence and indicators of attention and memory have been studied. Using regression analysis, the independent role both age and cognitive functions as intelligence predictors was revealed. A brief description of the created battery of computerized psychometric tests designed to assess different attention and memory functions is presented. This system can be used for activating individual reserves to improve specific domains of cognitive functions as basic components of IQ.
Diseño de un sistema de radio sobre fibra óptica para ondas milimétricas en redes móviles 5G

En el presente trabajo se propone una arquitectura de red para el transporte de ondas milimetricas (MMW) basada en la tecnologia de radio sobre fibra (RoF), el cual se usara en el fronnhaul de la red movil de proxima generacion 5G. En ella se propone una arquitectura de transmision punto a multipunto, desde una oficina central (CO) hasta un cluster de siete radio bases (RB) con el fin de posibilitar el re-uso de frecuencias en celdas aledanas. Los resultados de la arquitectura propuesta se basan en el analisis del comportamiento del factor de calidad (Q) y de la tasa de bits errados (BER) tanto en los enlaces descendentes como ascendentes de la comunicacion entre la CO y las BS. De igual manera, se hace una caracterizacion del comportamiento de las senales MMW respecto a los mismos factores de calidad, frente a diferentes frecuencias del espectro disponible de MMW. La propuesta aprovecha los beneficios de una doble modulacion en banda lateral unica para generar una subportadora optica para la transmision en el enlace descendente y una segunda subportadora para el transporte de los servicios en el enlace ascendente, asi como la centralizacion de las fuentes opticas. La evaluacion experimental de la arquitectura propuesta se basa en el analisis del rendimiento de la Tasa de Error de Bit (BER) y la Magnitud de Vector de Error (EVM) tanto en el enlace descendente como en el enlace ascendente.
Photon-counting optical time-domain reflectometry with superconducting nanowire single-photon detectors

We applied superconducting nanowire single-photon detectors to photon-counting optical time-domain reflectometry (OTDR). The setup was optimized to minimize the timing jitter of the photon detections to 42 ps. Therefore, we achieved a spatial resolution of 4 mm in our OTDR system. Based on the super high spatial resolution, we observed the reflection from a small fiber coil and see the peak width spread.
Dynamic Frustrated Lewis Pairs on Ceria for Direct Nonoxidative Coupling of Methane

While the regulation of surface oxygen vacancy (VO) of ceria is an effective methodology to construct solid frustrated Lewis pairs (FLPs), the intrinsic properties and potential applications of solid FLPs are not well-demonstrated. Herein, we present a theoretical study on the formation rules and dynamic behaviors of FLPs on CeO2(110) and their performance on nonoxidative conversion of methane. The density functional theory studies show that the formation of solid FLPs on CeO2(110) is dependent on the number of oxygen vacancies (VOs). The FLPs constructed by three or more VOs are stable in thermodynamics, whereas the FLPs containing few VOs (i.e., VO monomer and VO dimer) are less stable but can be dynamically formed via thermal fluctuation and reactant-adsorption, as observed by ab initio molecular dynamics simulations. Hence, the general existence of FLPs on reduced CeO2(110) surface under reaction conditions is revealed. Calculations on methane activation show that FLPs are active for C–H bond breaking.