Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Ctr 1 and Ctr 2 in Mammalian Copper Homeostasis and Platinum-based Chemotherapy

Copper (Cu) is an essential metal for growth and development that has the potential to be toxic if levels accumulate beyond the ability of cells to homeostatically balance uptake with detoxification. One system for Cu acquisition is the integral membrane Cu+ transporter, Ctr1, which has been quite well characterized in terms of its function and physiology. The mammalian Ctr2 protein has been a conundrum for the copper field, as it is structurally closely related to the high affinity Cu transporter Ctr1, sharing important motifs for Cu transport activity. However, in contrast to mammalian Ctr1, Ctr2 fails to suppress the Cu-dependent growth phenotype of yeast cells defective in Cu+ import, nor does it appreciably stimulate Cu acquisition when overexpressed in mammalian cells, underscoring important functional dissimilarities between the two proteins. Several roles for the mammalian Ctr2 have been suggested both in vitro and in vivo. Here, we summarize and discuss current insights into the Ctr2 protein and its interaction with Ctr1, its functions in mammalian Cu homeostasis and platinum-based chemotherapy.
Chemical Composition and Biological Potentials of Aqueous Extracts of Fennel ( Foeniculum vulgare L )

Foeniculum vulgare (fennel) has been widely used in Egyptian traditional medicine for treatment of various diseases. This study was designed to evaluate the potential of three aqueous extracts of fennel seeds with different extraction conditions (pH 3, 7 and 12) as natural antimicrobial, antiviral, antioxidant and antitumor agents from the safety point of view. The three aqueous extracts were then used for evaluation of yield, total carbohydrates, protein, flavenoid and total phenolic contents. Antioxidant activity was evaluated using the DPPH• radical scavenging. The results showed that the high anti-scavenging activity was noticed for three different aqueous extracts of fennel at 2.0 mg dose comparable to other doses. In addition, the antimicrobial activity of the aqueous extracts against tested Gram positive and negative bacteria, yeast and fungi strains was determined. The extract (concentration 1.6 mg/ ml) was effective against most of the strains tested, yet not against Candida albicans. These results show that water fennel extracts could be considered as a natural alternative to traditional food preservatives and be used to enhance food safety and shelf life. Plaque reduction infectivity assay was used to determine antiviral activity against herpes simplex virus type-1 (HSV-1) cells count reduction as a result of treatment with tested extracts. Acidic fennel and alkaline fennel extracts showed high activity with virucidal effect (83.4 and 58.2%, respectively). To evaluate in vitro the antitumor activity of fennel extracts, the cells were treated by fennel extracts at concentration 300, 600 and 900 ug/ml and the number of viable cells was determined by trypan blue test. In general, all three plant extracts showed moderate antitumor activity in the high concentration of extracts against the Ehrlich ascites carcinoma cells.
L EARNING B ACKPROPAGATION -F REE D EEP A RCHIT - ECTURES WITH K ERNELS

One can substitute each neuron in any neural network with a kernel machine and obtain a counterpart powered by kernel machines. The new network inherits the expressive power and architecture of the original but works in a more intuitive way since each node enjoys the simple interpretation as a hyperplane (in a reproducing kernel Hilbert space). Further, using the kernel multilayer perceptron as an example, we prove that in classification and under certain losses, an optimal representation that minimizes the risk of the network can be characterized for each hidden layer. This result removes the need of backpropagation in learning the model and can be generalized to any feedforward kernel network. Moreover, unlike backpropagation, which turns models into black boxes, the optimal hidden representation enjoys an intuitive geometric interpretation, making the dynamics of learning in a deep kernel network transparent. Empirical results are provided to complement our theory.
Mobile Feelings: Wireless Communication of Heartbeat and Breath for Mobile Art

"Mobile Feelings" is a mobile art project where users can send and receive body data over a wireless communication network. Specially designed “Mobile Feelings” devices allow remote users to feel each others’ heartbeat signals and breath over distance. The system explores novel forms of intuitive and non-verbal communications that go beyond the conventional transmission of voice, sounds and images used in standard mobile communication. "Mobile Feelings" enables intuitive bodily communication between remote users by exploring the emotional quality of touch and breath as some of the less explored communication senses.
Rat intestinal sucrase. II. The effects of rat age and sex and of diet on sucrase activity.

Intestinal sucrase activity of the rat varies with the age, but not the sex, of the animal. Sucrase activity of rats 23 days of age was approximately two-thirds that of adults.Sucrase activity of adult rats was significantly decreased by several days of fasting. The decrease was rapid during the first 2 to 4 days of the fast, but became negligible thereafter.Diets containing large (70%) amounts of sucrose, galactose, melizitose, or α-methyl-D-glucoside produced highly significant increases in intestinal sucrase levels (compared with a carbohydrate-free, high-casein control diet) when fed ad libitum for 24 hours to adult male rats previously fasted for 3 days. Similar diets containing fructose, fructose plus glucose in equimolar amounts, or maltose significantly increased sucrase activity, but diets containing glucose, mannose, xylose, or lactose were not stimulatory. A 70% raffinose diet significantly decreased sucrase activity. Normal male rats which were fed the 70% sucrose diet for 4 weeks had sucrase .
Long-term trends in the wind supply in the Netherlands

Different measures for wind energy potential show very different long-term variations and trends. This seriously complicates the estimation of future long-term wind supply. Therefore, it is necessary to better understand these discrepancies. know the main causes of the reported decline. For this purpose different types of indices for the Netherlands are analysed and the influential production based index Windex-CBS is compared to different wind speed observation indices and to an index based on geostrophic wind speed.
Electron Microscopy of Biological Macromolecules: Bridging the Gap between What Physics Allows and What We Currently Can Get

The resolution achieved in low-dose electron microscopy of biological macromolecules is significantly worse than what can be obtained on the same microscopes with more robust specimens. When two-dimensional crystals are used, it is also apparent that the high-resolution image contrast is much less than what it could be if the images were perfect. Because specimen charging is one factor that might limit the contrast and resolution achieved with biological specimens, we have investigated the use of holey support films that have been coated with a metallic film before depositing specimens onto a thin carbon film that is suspended over the holes. Monolayer crystals of paraffin (C44H90) are used as a test specimen for this work because of the relative ease in imaging Bragg spacings at ∼0.4 nm resolution, the relative ease of measuring the contrast in these images, and the similar degree of radiation sensitivity of these crystals when compared to biological macromolecules. A metallic coating on the surrounding support film does, indeed, produce a significant improvement in the high-resolution contrast for a small fraction of the images. The majority of images show little obvious improvement, however, and even the coated area of the support film continues to show a significant amount of beam-induced movement under low-dose conditions. The fact that the contrast in the best images can be as much as 25%–35% of what it would be in a perfect image is nevertheless encouraging, demonstrating that it should be possible, in principle, to achieve the same performance for every image. Routine data collection of this quality would make it possible to determine the structure of large, macromolecular complexes without the need to grow crystals of these difficult specimen materials.
THE INFLUENCE OF VEGETATION ON EROSION FOLLOWING RESTORATION IN HIGH ZONES DER EINFLUSS DER VEGETATION AUF DAS EROSIONS-GESCHEHEN IN HOCHLAGEN NACH REKULTIVIERUNGEN

The new powder snow avalanche model – SamosAT – was initiated in 2004 by the Forest Technical Service for Avalanche and Torrent Control and released in the end of 2007. The advanced model provides simulation tools for dense and for powder flow avalanches. The previous Samos simulation platform has been completely redesigned in order to provide improved results and an easier software handling. In regard of these enhanced technologies the name Samos has been extended by the affix AT for Advanced Technology. The calibration of the model was done with 22 well documented reference avalanches. In a systematic study all internal parameters were analysed and adjusted to the reference data. By creating matrices with the decisive model parameters and the reference avalanches the suitable calibration values for the denseand powder flow model were determined.
Which Firms Want PhDs? The Effect of the University-Industry Relationship on the PhD Labour Market

PhD graduates hold the highest education degree, are trained to conduct research and can be considered a key element in the creation, commercialization and diffusion of innovations. The impact of PhDs on innovation and economic development takes place through several channels such as the accumulation of scientific capital stock, the enhancement of technology transfers and the promotion of cooperation relationships in innovation processes. Although the placement of PhDs in industry provides a very important mechanism for transmitting knowledge from universities to firms, information about the characteristics of the firms that employ PhDs is very scarce. The goal of this paper is to improve understanding of the determinants of the demand for PhDs in the private sector. Three main potential determinants of the demand for PhDs are considered: cooperation between firms and universities, R&D activities of firms and several characteristics of firms, size, sector, productivity and age. The results from the econometric analysis show that cooperation between firms and universities encourages firms to recruit PhDs and point to the existence of accumulative effects in the hiring of PhD graduates.
Otitis Media with Effusion

Otitis media with effusion (OME), also called glue ear, is characterised by a collection of fluid in the middle-ear cleft. there is chronic inflammation but without signs of acute inflammation. OME is the most common cause of hearing impairment (and the most common reason for elective surgery) in childhood, where it usually follows an episode of acute otitis media (AOM). It is uncommon in adults, in whom Eustachian tube dysfunction is the predominant cause and suspicious aetiologies should be considered. [1]
Extraction of lipids from the raw materials for beer production and development of methods for phytosterols ’ determination by high performance liquid chromatography ( HPLC )

The study of phytosterols’ content in the raw materials for beer production is one of the new research problems that arose with a significant increase in beer consumption in the recent years. There is a theory that the content of phytosterols in beer is so significant that could have a negative impact on the human body. Hops and malt were selected to study the phytosterols’ content in the raw materials for beer production. Studies using the high performance liquid chromatography (HPLC) with mass detection showed presence of following phytosterols in malt and hops: stigmasterol, beta-sitosterol, campesterol, and brassicasterol.
Brasilia Parkinson Cohort: assessing clinical, neuropsychological and imaging predictors of cognitive decline in Parkinson's disease

The following study protocol describes the rationale and methods of a cohort with a nested case-control study, which aims to identify risk factors and predictors of cognitive dysfunction in Parkinson's disease (PD). It is a study that will follow PD every 18 months with a comprehensive neuropsychological, clinical (motor and non-motor symptoms) and imaging (Magnetic Resonance Imaging) data collection. The criteria for diagnosing mild cognitive impairment (MCI) and dementia will respect the parameters previously published by the International Working Group on Mild Cognitive Impairment, and compared with those recommended by the Fifth edition of the Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association (DSM-5) and the International Parkinson's and Movement Disorders Society (MDS) criteria. We will also evaluate the neural substrate and underpinnings of PD non-motor symptoms, using advanced neuroimaging techniques, such as diffusion tensor imaging (DTI) and gray matter and white matter volumetric measurements.
PODIGAWE NA C-REAKTIVEN PROTEIN NA SERUMOT I S100 PROTEINI ZA SISTEMSKOTO VOSPALENIE KAJ

Rezime Abstract Patogenezata na autizmot, nevrolo{ko naru{uvawe {to seriozno vlijae vrz malite deca, mo`e da gi vklu~i vospalenijata i avtoimunitetot. Vo ovoj izve{taj, se ispituva distribucijata na C-reaktivniot protein vo akutna faza (CRP) i S100 proteinite kaj normalni i decata so autizam. Nivoto na nivniot serum e mereno so proba na imunoatsorbent vrzan so enzimi (ELISA). Kaj decata so autizam se najdeni zna~itelno povisoki od normalni nivoa na CRP (p=0.005) i S100 (p=0.03) proteini. Postoeweto na podignatite nivoa na CRP i S100 proteini kaj decata so autizam e odli~en znak za sistemsko vospalenie {to mo`e da pridonese za nevropatologija na ova naru{uvawe na mozokot. The pathogenesis of autism, a neurological disorder severely affecting young children, may involve inflammation and autoimmunity. In this report, the distribution of acute-phase C-reactive protein (CRP) and S100 proteins was examined in normal and autistic children. Their serum levels were measured by enzyme-linked immunosorbent assay (ELISA). Autistic children were found to have significantly higher than normal levels of CRP (p=0.005) and S100 proteins (p=0.03). The existence of elevated levels of CRP and S100 proteins in autistic children is an excellent sign of systemic inflammation that may contribute to the neuropathology of this brain disorder.
Effect of hydrostatic Pressure on Morphology and Expression of VE-Cadherin of Vascular Endothelial Cells

Bovine aortic endothelial cells (BAECs) were exposed to hydrostatic pressure of 50, 100, and 150 mmHg and changes in morphology and expression of VE-cadherin were studied. After exposure to hydrostatic pressure, BAECs exhibited elongated and tortuous shape without predominant orientation, together with the development of centrally located, thick stress fibers. Pressured BAECs also exhibited a multilayered structure unlike those under control conditions and showed a significant increase in proliferation compared with control cells. Western blot analysis demonstrated that protein level of VEcadherin were significantly lower under pressure conditions than under control conditions. Inhibition of VE-cadherin expression, using an antibody to VEcadherin, induced the formation of numerous randomly distributed intercellular gaps, elongated and tortuous shapes, and multilayering. These responses were similar to those of pressured BAECs. The exposure of BAECs to hydrostatic pressure may therefore downregulate the expression of VE-cadherin, resulting in loss of contact inhibition followed by increased proliferation and formation of a multilayered structure.
Structural approach to the inverse problems of computational diagnostics in cardiology

The methods to identify the structural invariants of the evolving test object using projection data are offered within the framework of the group-theoretical statistical approach. The essence of the inverse reconstructive problem within the structural approach is investigated. The features of the inverse problems arising in the study of developing open system are discussed. The advantages of the stroboscopic data acquisition in hardware–software implementation of the group-theoretical statistical reconstructive methods are explored. The concept of phase time is introduced, and the methods of stroboscopic reconstructive diagnostics in phase time are developed. The electrocardiogram (ECG)controlled systems for X-ray medical reconstructive diagnostics are designed. The basic types of reconstructive — problems for evolving test objects are considered.
Title : Recognizing speakers across languages

Listeners identify voices more accurately in their native language than an unknown, foreign language, in a phenomenon known as the language-familiarity effect in talker identification. This effect has been reliably observed for a wide range of different language pairings and using a variety of different methodologies, including voice line-ups, talker identification training, and talker discrimination. What do listeners know about their native language that helps them recognize voices more accurately? Do listeners gain access to this knowledge when they learn a second language? Is linguistic competence necessary, or can mere exposure to a foreign language help listeners identify voices more accurately? In this chapter, I review the more than three decades of research on the language-familiarity effect in talker identification with an emphasis on how attention to this phenomenon can inform not only better psychological and neural models of memory for voices, but also better models of speech processing.
Monitorización de la subsidencia del terreno de la Vega Media del río Segura mediante Interferometría SAR Diferencial Avanzada

La subsidencia implica el asentamiento de la superficie terrestre en un área extensa debido a varios factores, que pueden ser naturales o causados por el impacto de una gran variedad de actividades humanas (Corapcioglu, 1984). Aunque se trata de un fenómeno que no ocasiona víctimas mortales, los daños económicos y sociales que causa suelen ser cuantiosos. Es de gran importancia en zonas urbanas donde los daños y perjuiMonitorización de la subsidencia del terreno de la Vega Media del río Segura mediante Interferometría SAR Diferencial Avanzada
Design of 24 GHz Frequency Source based on Phase Noise Analysis

A 24 GHz Phase-Locked Loop (PLL) frequency source based on the analysis of the phase noise of the system is presented. Instead of using Direct Digital Synthesizer (DDS) and the combination of DDS and PLL, the design method of a single PLL circuit is adopted in this paper. Based on the phase noise model of the PLL system, it is concluded that the selection of loop bandwidth determines the phase noise performance of the frequency source by analyzing the characteristics of the phase noise transfer function of each noise source. ADIsimPLL4.10 software is used to adjust the bandwidth of the Loop Filter, so that the designed Loop Filter meets the design requirements of the 24GHz microwave frequency source. The test results show that output frequency of the frequency source is at 24.17GHz, and its phase noise is -102.48dBc/Hz@10kHz. Compared with the frequency source designed by other methods, this design has the advantage of low phase noise. Keywords—PLL; frequency source; loop bandwidth; low phase noise
Brain Haemorrhage and Cerebral Vasospasm Associated with Chronic Use of Cannabis and Buprenorphine

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Menstrual Respiratory Changes and Symptoms

Summary The duration of standardised overbreathing required to produce slow wave activity in the EEG during different phases of the menstrual cycle has been studied, and changes in carbon dioxide sensitivity of the respiratory system. Normal subjects developed slow waves more quickly and had more sensitive CO2 responses during the premenstrual/menstrual phases. This may be a factor contributing to premenstrual tension.
A Model-Driven Approach to Formalize and Support Controlled Experiments in Software Engineering

In this paper, we present the main goals, questions and hypotheses of our research related to provide automated support environments to conduct controlled experiments in software engineering (SE). Here, we introduce a model-driven approach that has been developed for supporting the formalization and execution of SE experiments. It consists of: (i) a domain specific language (DSL) for process specification and statistical design of controlled experiments; (ii) model-driven transformations that promote the generation of workflow models specific to each experiment participant and according to the experiment statistical design; and (iii) a workflow execution environment that allows the monitoring of participant activities in the experiment. In addition, we present the planning of empirical studies for this approach. The research was divided in phases and each phase has empirical studies defined in order to validate it and answer our research questions. Each phase adopts cycles of successive approximations (generateand-test cycles).
Decals prevent bird-window collisions at residences : a successful case study from Colombia Calcomanías evitan colisiones de aves contra ventanas de residencias : estudio de un caso exitoso de Colombia

Collisions with windows are responsible for one billion annual bird deaths in the United States alone, and are the second greatest cause of human-caused bird mortality. Although windows can be a significant threat to Neotropical birds, few studies have quantified collisions and none have targeted residences in this tropical region. Research in the United States and Canada has shown that residences are responsible for 44% and 90% of the window collisions, respectively. We studied bird-window collisions at a rural residence in a 4-hectare nature reserve located on the Eastern Andes piedmont in Colombia. Large and abundant windows provided attractive views but also resulted in frequent collision events, many of which were fatal. Between 2009 and 2012, we tested the effect of bird deterrent decals on collision reduction. After bird decal application on five windows (0.41 decals/m) collisions were reduced by 84% in 36.32m total glass area. We show a successful case of residence-scale collision prevention to inspire other homes to stop bird mortality.