Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Ventromedial Hypothalamic Lesions on Circadian Rhythms in Serum Insulin, Glucose, Triglyceride and Food Intake in Rats

The effects of ventromedial hypothalamic (VMH) lesions on the circadian periodicity of serum insulin, glucose, triglyceride and food intake were studied in rats. The rhythms of serum insulin, glucose and triglyceride did not persist in VMH lesioned rats. The glucose level during the light period was reduced. The triglyceride and insulin levels were elevated. The VMH lesions markedly increased food intake during the later half part of the light cycle but kept it significantly less during the first half part. Thus, the VMH lesions abolished the circadian rhythmicity of serum insulin, glucose and triglyceride and attenuated the rhythmicity of eating through increase in daytime consumption.
A vector controlled single-phase voltage source inverter with enhanced dynamic response

Vector (dq) control is a powerful technique used in high dynamic performance inverters. The transformation of ac into dc quantities allows the controller to be designed as for dc-dc converters, with infinite gain at the steady-state operating point for zero steady-state error. It can be easily implemented for three-phase inverters but presents some challenges for single-phase ones. The orthogonal component (β) required for the stationary to rotating frame transformation does not exist and is usually created by phase shifting the real one (α) by ¼ of a line cycle, what deteriorates the dynamic response. Recently an approach where the orthogonal quantity is obtained by emulating a fictitious orthogonal circuit has been proposed. This paper shows that the results obtained with this new approach are better than with the ¼ line cycle delay and that the α and β components become identical to those of a three-phase inverter. Simulation and experimental results are presented.
Lifestyle factors on the risks of ischemic and hemorrhagic stroke.

BACKGROUND The joint effects of different lifestyle factors on stroke risk are still to some extent unclear, especially regarding hemorrhagic stroke. METHODS We prospectively investigated the association of different indicators of lifestyle (smoking, body mass index, physical activity, and vegetable and alcohol consumption) with total and type-specific stroke incidence among 36 686 Finnish participants who were 25 to 74 years old and free of coronary heart disease and stroke at baseline. RESULTS During a mean follow-up period of 13.7 years, 1478 people developed an incident stroke event (1167 ischemic and 311 hemorrhagic). The multivariate-adjusted (age, sex, education, family history of stroke, history of diabetes mellitus, systolic blood pressure, and serum total cholesterol level) hazard ratios associated with adherence to 0 to 1 (reference group), 2, 3, 4, and 5 healthy lifestyle indicators were 1, 0.66, 0.57, 0.51, and 0.33 (P < .001 for trend) for total stroke; 1, 0.67, 0.60, 0.50, and 0.30 (P < .001 for trend) for ischemic stroke; and 1, 0.63, 0.49, 0.49, and 0.40 (P < .001 for trend) for hemorrhagic stroke, respectively. These inverse associations were similar in both men and women. The partial population attributable risk percentages associated with adherence to 3, 4, and 5 healthy lifestyle indicators were 26.3%, 43.8%, and 54.6% for total stroke; 22.7%, 45.3%, and 59.7% for ischemic stroke; and 35.0%, 35.0%, and 36.1% for hemorrhagic stroke, respectively. CONCLUSION Healthy lifestyle factors are associated with a lower risk of stroke, and there is a graded inverse association between the number of healthy lifestyle indicators and the risks of total, ischemic, and hemorrhagic stroke.
Agrégation de traces d'exécution pour la visualisation de grands systèmes distribués

RÉSUMÉ. La visualisation de performance consiste à représenter graphiquement l’exécution d’applications parallèles pour procéder à leur analyse. Dans le cas de très grands systèmes, l’agrégation des données analysées est inévitable. Cet article met en évidence un problème scientifique majeur : comment produire des représentations agrégées qui ont un sens lors du passage à l’échelle ? Quatre éléments de réponse sont discutés. (1) Les outils de visualisation doivent garantir la compréhension et le contrôle par l’utilisateur du procédé d’agrégation. (2) Il est crucial d’estimer la qualité des représentations engendrées afin de distinguer les agrégations utiles (suppression d’informations redondantes) de celles qui sont dangereuses pour l’analyse (perte d’informations importantes). Nous proposons des mesures issues de la théorie de l’information pour quantifier ces deux aspects et pour ainsi engendrer des représentations multirésolutions (agrégation de données redondantes et conservation des données hétérogènes). (3) Les propriétés sémantiques et topologiques du système doivent également être prises en compte afin de garantir la juste interprétation des agrégats par l’utilisateur. La recherche des agrégations optimales est ainsi restreinte à un ensemble d’agrégations pertinentes sur le plan sémantique. (4) Des méthodes de calcul sophistiquées sont alors nécessaires pour sélectionner les agrégations optimales lors du passage à l’échelle. Nous proposons un algorithme à complexité linéaire (dans le cas de systèmes hiérarchiques) parvenant à agréger jusqu’à un million d’entités et garantissant l’interprétabilité des visualisations engendrées.
Patterns in Strategic IS Planning Decisions: An Inductive Approach

Alignment between business strategy and IS strategy is relevant to most large organizations today. We build on the literature on alignment and strategic IS planning to study patterns of antecedents that explain planning decisions. When addressing misalignment risks: Are there systematic differences in the patterns of antecedents that explain decision-making across differing strategic orientations? This research question guides our investigation. By adopting an inductive learning methodology, a unique dataset – collected from a multi-business Fortune 10 organization – of proposed IS initiatives and the actual planning decisions is analyzed. We present insightful decision models and provide empirical support to suggest that strategic orientation is a key driver explaining the differences in decision-making during strategic IS planning.
[The relationship between tumor angiogenesis and cellular proliferation activity in nasal inverted papilloma].

OBJECTIVE To investigate the expression of CD34 and proliferating cell nuclear antigen (PCNA) and to study the relationship between tumor angiogenesis and cellular proliferation activity in nasal inverted papilloma (NIP). METHOD The expression of CD34 protein and proliferating cell nuclear antigen were detected in 30 cases of NIP, 16 cases of nasal polyps (NP) and 11 cases of nasal squamous cell carcinoma (NSCC) with immunohistochemical S-P method and the tumor angiogenesis (as assessed by MVD) and cellular proliferation activity (as assessed by PCNA labeling index, PCNA-LI) was evaluated. RESULT A significant difference in CD34 expression was found among the three diseases above mentioned. The MVD were 32.41 +/- 5.68; 53.22 +/- 9.31 and 80.37 +/- 10.21 in NP, NIP and NSCC. The expression rate of PCNA (PCNA-LI) was 28.67 +/- 9.29; 35.35 +/- 7.02 and 63.18 +/- 12.17 in NP, NIP and NSCC (P<0.01). There was a significant difference in PCNA expression among the three diseases (P<0.01). A significant positive correlation was found between MVD and PCNA-LI (r=0.56, P<0.01). Tumors with a low PCNA-LI was associated with low MVD and vice versa. CONCLUSION With a significant relation between tumor angiogenesis, cellular proliferation activity and pathological types, MVD, PCNA-LI can be used as a strong independent indicator to judge tumor aggressive behavior, proliferative activity, development of local or regional metastases and prognosis in nasal inverted papilloma.
NATIONAL IDENTITY IN A POPULAR SCOTTISH COMIC

The present paper summarises the results of my Ph.D. thesis “The Scottishness of Oor Wullie” (Ruprecht-Karls University of Heidelberg, unpublished), which analysed a Scottish comic series from a cultural and sociolinguistic perspective. Oor Wullie, also known as “Our little William” is a series of comics which has been published by the Scottish Sunday Post since 1936. It is a central element of Scottish popular culture: “Reading Oor Wullie is among the 100 most important things to do in Scotland before dying” (Glasgow Herald, 28 March 2004). Dudley Watkins, the original artist, was not drafted for military service because the nation profited enormously from Oor Wullie, which served not only an entertaining, but also a unifying and supportive function. As part of the Tartan Day festivities in April 2004, Oor Wullie, the protagonist, was voted the most important Scottish icon of the year. With its Scottish themes, language and humour, Oor Wullie appeals to the entire social and age spectrum. The partly nostalgic representation of the Scots language supports the group identity of the nation by reminding its readers of their cultural good, which was once a full working language. The contact between Scots and Scottish English becomes apparent.
Miniature omni-directional ultra-wideband antenna

A miniature omni-directional ultra-wideband planar monopole antenna is designed using finite Difference Time Domain (FDTD) method. The antenna includes a planar circular disc as a monopole, a uniform microstrip feed line, a tapered microstrip feed line and a double-feed technique. Ground plane composes a gradually changeable structure to improve the performance of the antenna. Measured results show that −10dB S11 bandwidth is from 2.82 GHz to 12 GHz for the proposed antenna. The measured results are in good agreement with simulated ones.
Do ask, do tell: clinicians and the U.S. National AIDS strategy.

Despite evidence that earlier initiation of antiretroviral treatment can decrease HIV transmission, the number of new infections has only decreased modestly in recent years in the United States from 48 600 to 47 500 between 2006 and 2010 [1–4]. Other metrics have also suggested that progress is being made, with HIV status awareness increasing from 80.9 to 84.2%, and the HIV transmission rate decreasing from 4.6 to 4.2% during the same time period. However, although virologic surpression rates of patients in care have improved in recent years, by 2010, only 41.7% of HIV-infected MSM were virologically suppressed, and the rates were lower among AfricanAmerican (34.9%) and Latino patients (37.2%).
The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye

Background NCX 434 is a nitric oxide (NO)-donating triamcinolone acetonide (TA), shown to enhance optic nerve head (ONH) oxygen saturation in non-human primate eyes. Here, the effects of a single intravitreal (IVT) injection of TA were compared with those of NCX 434 on intraocular pressure (IOP), retinal function and retrobulbar haemodymamics in endothelin-1 (ET-1) induced ONH ischaemia/reperfusion in rabbits. Biochemical changes were also assessed in the aqueous humour and in retinal biopsies. Methods IOP and resistivity index of ophthalmic artery (RI-OA) were recorded using TonoPen and ecocolor Doppler, respectively. Retinal function was assessed using photopic electroretinography. Cytokine expression and oxidative stress markers were evaluated with immunoassay techniques. Results At 4 weeks post IVT treatment, TA increased IOP and RI-OA while NCX 434 did not (IOPVehicle=13.6±1.3, IOPNCX 434=16.9±2.2, IOPTA=20.9±1.9 mm Hg; p<0.05 vs vehicle; RI-OAVehicle=0.44±0.03; RI-OANCX 434=0.47±0.02; RI-OATA=0.60±0.04). Both NCX 434 and TA reversed ET-1 induced decrease in electroretinography amplitude to similar extents. NCX 434 attenuated ET-1 induced oxidative stress markers and nitrotyrosine in retinal tissue, and interleukin-6 and tumour necrosis factor-α in aqueous humour more effectively than TA. Conclusion NCX 434 attenuates ET-1 induced ischaemia/reperfusion damage without increasing IOP, probably due to NO release. If data are confirmed in other species and models, this compound could represent an interesting new therapeutic option for retinal and ONH diseases, including diabetic retinopathy.
Detection of anti‐epstein‐barr‐virus transactivator (ZEBRA) antibodies in sera from patients with nasopharyngeal carcinoma

The Epstein‐Barr virus (EBV) is a ubiquitous Herpes virus which causes infectious mononucleosis and is associated with such different neoplasms as Burkitt's lymphoma and nasopharyngeal carcinoma. EBV latently infects its target cells; nevertheless, evidence of viral replication in NPC tumours has been uncovered. Among the EBV transactivators, the ZEBRA protein plays a crucial role in switching the virus from a latent to a productive mode. ZEBRA protein was produced using a eukaryotlc expression vector: the open reading frame containing the BZFLI cDNA has previously been inserted downstream from the adenovirus major late promoter leading to expression of a 38‐kDa nuclear protein. We performed serological studies by employing ZEBRA protein expressed in human cells for immunofluorescence and Western‐blot assays. We were able to detect IgG anti‐ZEBRA antibodies (IgG/ZEBRA) in 87% of NPC patients. These antibodies were absent in control sera; IgG/ZEBRA antibodies can be proposed as a useful marker for diagnosis of NPC tumors.
An Evidence-Based Systematic Review of Vitamin A by the Natural Standard Research Collaboration

ABSTRACT An evidence-based systematic review of vitamin A by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated and reproducible grading rationale. This paper includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
Correction: No Acute Effect of Reduced-exertion High-intensity Interval Training (REHIT) on Insulin Sensitivity

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Monoclonal Antibody-based Immunohistochemical Detection of Bovine Viral Diarrhea Virus in Formalin-fixed, Paraffin-embedded Tissues

Thirty-two monoclonal antibodies directed against epitopes on bovine viral diarrhea virus proteins and glycoproteins were tested for immunohistochemical reactivity with bovine viral diarrhea virus in formalin-fixed and paraffin-embedded tissues from 45 cases of bovine viral diarrhea virus-associated mucosal disease. Only one antibody, designated 15C5, which reacts with the 48-kD glycoprotein of bovine viral diarrhea virus, detected an epitope preserved in these specimens. Monoclonal antibody 15C5 and a polyclonal antibody to bovine viral diarrhea virus successfully detected bovine viral diarrhea viral antigens in 44/45 cases of mucosal disease and did not react with formalin-fixed tissues from 30 uninfected cattle. Monoclonal antibody-based immunohistochemical detection of bovine viral diarrhea virus in routinely fixed tissue specimens has advantages over other currently available techniques in terms of the convenience of specimen submission, the relative ease of method standardization, and the rapidity of the test, and by enabling identification of the virus in association with specific tissues, cell types, and histologic lesions.
Analysis and Design of Robust Multi-Gb/s Clock and Data Recovery Circuits

The bandwidth demands of modern computing systems have been continually increasing and the recent focus on parallel processing will only increase the demands placed on data communication circuits. As data rates enter the multi-Gb/s range, serial data communication architectures become attractive as compared to parallel architectures. Serial architectures have long been used in fibre optic systems for long-haul applications, however, in the past decade there has been a trend towards multi-Gb/s backplane interconnects. The integration of clock and data recovery circuits into monolithic integrated circuits is attractive as it improves performance and reduces the system cost, however it also introduces new challenges, one of which is robustness. In serial data communication systems the CDR circuit is responsible for recovering the data from an incoming data stream. In recent years there has been a great deal of research into integrating CDR circuits into monolithic integrated circuits. Most research has focused on increasing the bandwidth of the circuits, however in order to integrate multi-Gb/s CDR circuits robustness, as well as performance, must be considered. In this thesis CDR circuits are analyzed with respect to their robustness. The phase detector is a critical block in a CDR circuit and its robustness will play a significant role in determining the overall performance in the presence of process non-idealities. Several phase detector architectures are analyzed to determine the effects of process non-idealities. Static phase offsets are introduced as a figure of merit for phase detectors and a mathematical framework is described to characterize the negative effects of static phase offsets on CDR circuits. Two approaches are taken to improve the robustness of CDR circuits. First, calibration circuits are introduced which correct for static phase offsets in CDR circuits. Secondly, phase detector circuits are introduced which have been designed to optimize both performance and robustness. Several prototype chips which implement these schemes will be described and measured results will be presented. These results show that while CDR circuits are vulnerable to the effects of process non-idealities, there are circuit techniques which can mitigate many of these concerns.
Development of a Novel Biofilm Continuous Culture Method for Simultaneous Assessment of Architecture and Gaseous Metabolite Production

ABSTRACT The way that gaseous metabolite production changes along with biofilm architecture development is poorly understood. To address this question, we developed a novel flow reactor biofilm culture method that allows for simultaneous assessment of gaseous metabolite production and architecture visualization. In this report, we establish the utility of this method using denitrification by Pseudomonas aeruginosa biofilms as a model system. Using this method, we were able to collect and analyze gaseous metabolites produced by denitrification and also visualize biofilm architecture in a nondestructive manner. Thus, we propose that this novel method is a powerful tool to investigate potential relationships between biofilm architecture and the gas-producing metabolic activity of biofilms, providing new insights into biofilm ecology.
The Past in Snorri Sturluson's Heimskringla

The radical difference between the past and the present is mostly regarded as an invention of the late eighteenth and early nineteenth century, which marks the origin of the modern understanding of history. Does this mean that in the Middle Ages there was no idea of the past being different? The article will examine this question on the basis of one text, Snorri Sturluson’s Heimskringla, which deals with the history of the Norwegian dynasty from Roman times until 1177. The focus will be on two events, the introduction of Christianity and the unification of the kingdom under one king.
Factors associated with the occurrence of adverse events in critical elderly patients.

Objective: to identify the factors associated with the occurrence of adverse events in critical elderly patients admitted to intensive care unit according to demographic and clinical characteristics. Method: a retrospective cohort study was conducted in nine units of a teaching hospital. Data were collected from medical records and from monitoring of nursing shift change. We used the t-test/Mann-Whitney, chi-square and logistic regression to test associations. Significance level of 5% was used. Results: out of the 315 elderly, 94 experienced events. Those who experienced events were men (60.6%) with mean age of 70.7 years, length of hospital stay of 10.6 days and survivors (61.7%). Most of the 183 events were clinical processes and procedures (37.1%). There was an association between adverse event and length of hospital stay in the unit (p=0.000; OR=1.10, 95% CI [1.06, 1.14]). Conclusion: the identification of associated events and factors in the elderly subsidize the prevention of these occurrences before the vulnerability of this age group.
Facilitation of L-Type Ca2+ Channels in Dendritic Spines by Activation of β2 Adrenergic Receptors

We studied the contribution of L-type Ca2+ channels to action potential-evoked Ca2+ influx in dendritic spines of CA1 pyramidal neurons and the modulation of these channels by the β2 adrenergic receptor. Backpropagating action potentials (bAPs) (three at 50 Hz) were evoked by brief somatic current injections, and Ca2+ transients were recorded in proximal basal dendrites and associated spines. The R- and T-type Ca2+ channel blocker NiCl2 (100 μm) significantly reduced Ca2+ transients in both spines and their parent dendrites (∼50%), suggesting that these channels are the major source of bAP-evoked Ca2+ influx in these structures. The L-type Ca2+ channel blockers nimodipine and nifedipine (both 10 μm) reduced spine Ca2+ transients by ∼10%, whereas the L-type Ca2+ channel activators FPL 64176 (2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methylester) and Bay K 8644 ((±)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-pyridine carboxylic acid methyl ester) (both 10 μm) significantly enhanced the spine Ca2+ transients by 40-50%. Activation of β2 adrenergic receptors with salbutamol (40 μm) or formoterol (5 μm) resulted in significant enhancements of the spine (40-50%) but not dendritic Ca2+ transients. This increase was prevented when L-type Ca2+ channels were blocked with nimodipine (10 μm) or when cAMP-dependent protein kinase A (PKA) was inhibited with KT5720 (3 μm), Rp-cAMPS (Rp-adenosine cyclic 3′,5′-phosphorothioate) (100 μm), or PKI (100 μm). The above data suggest that L-type Ca2+ channels are functionally present in dendritic spines of CA1 pyramidal neurons, contribute to spine Ca2+ influx, and can be modulated by the β2 adrenergic receptor through PKA in a highly compartmentalized manner.
L’évaluation gériatrique standardisée : intérêt et modalités

Auteur(s) :, Paule Le Deun, Armelle Gentric* Hopital de la Cavale Blanche, Medecine interne et Geriatrie, 29609 Brest Cedex Tel. : 02 98 34 71 91 *Armelle Gentric Une nouvelle approche medicale de la personne âgee, dans sa globalite medico-psychosociale, a vu le jour il y a une vingtaine d’annees aux USA : l’evaluation gerontologique standardisee (EGS) ou comprehensive geriatric assessment des Anglo-saxons. De nombreux travaux ont montre que l’EGS permet [. ]