Miracle-dz/UniFAR-FTUs huggingface dataset:
The Epidemiology of Depressive Symptoms in the Last Year of Life

Depression impacts quality of life at all life stages, but the epidemiology of depression in the last year of life is unknown. This study's objectives were to document the epidemiology of depressive symptoms in the year prior to death and to assess how the trajectory of depressive symptoms varies by sociodemographic and clinical factors.
Frequency-Hopping Signal Sorting Based on Deep Leaming

In order to solve the problem that the sorting threshold of traditional frequency-hopping signal needs to be manually adjusted, Faster-RCNN and clustering algorithm is proposed. In this paper, the Faster-RCNN is firstly used to identify and locate all frequency-hopping points in the time- frequency spectrum diagram, and then AlexNet is used to obtain the number of frequency-hopping signal. Experimental results show that the Faster-RCNN can be effectively used for automatic signal sorting when the number of frequency- hopping signal is small.
Alkali 〈I⋅S〉 wall relaxation in dichlorodimethylsilane coated resonance cells

Alkali 〈I⋅S〉 wall relation rates for Pyrex resonance cells coated with dichlorodimethylsilane have been studied. In particular, by considering the ratio of the Rb85 wall relaxation rate to the Rb87 wall relaxation rate, evidence is presented showing that dimethylsiloxane surfaces and alkane (paraffin) surfaces relax alkali polarization with similar interaction strengths and correlation times. This conclusion indicates that the outer most functional group of an organic surface molecule has the primary influence on the alkali polarization’s surface relaxation.
Emerging Highly Virulent Porcine Epidemic Diarrhea Virus: Molecular Mechanisms of Attenuation and Rational Design of Live Attenuated Vaccines

The highly virulent porcine epidemic diarrhea virus (PEDV) emerged in China in 2010. It infects pigs of all ages, and causes severe diarrhea and high mortality rates in newborn pigs, leading to devastating economic losses in the pork industry worldwide. Effective and safe vaccines against highly virulent PEDV strains are still unavailable, hampering the further prevention, control and eradication of the disease in herds. Vaccination of pregnant sows with live attenuated vaccines (LAVs) is the most effective strategy to induce lactogenic immunity in the sows, which provides A passive protection of suckling piglets against PEDV via the colostrum (beestings, or first milk) and milk. Several LAV candidates have been developed via serially passaging the highly virulent PEDV isolates in non-porcine Vero cells. However, their efficacies in the induction of sufficient protection against virulent PEDV challenge vary in vivo. In this review, we summarize the current knowledge of the virulence-related mutations of PEDV and their potential roles in PEDV attenuation in vivo. With the successful development of reverse genetics systems for PEDV, we also discuss how to use them to generate promising LAV candidates that are safe, effective and genetically stable. This article provides timely insight into the rational design of effective and safe PEDV LAV candidates.
A body shape index in a small sample of Saudi adults with type 2 diabetes

Context: Overweight and obesity are assessed clinically using the body mass index (BMI), but the index is criticized as a crude measure of relative fat-muscle composition. The recently introduced a body shape index (ABSI) is an independent and more accurate predictor of mortality than other anthropometric measures. Aims: Describe ABSI in relation to other clinical and cardiometabolic risk factors in Saudi patients with type 2 diabetes. Settings and Design: Cross-sectional, armed forces diabetes clinic. Materials and Methods: Demographic and clinical data were obtained from randomly sampled patients with type 2 diabetes. Statistical Analysis: The t test, analysis of variance, or Chi-square test as appropriate, and contingency table analysis. Results: The 120 patients with type 2 diabetes (60 males, 60 females) had a mean (SD) age of 52.5 (9.3) years and BMI of 31.8 (5.5). Comparisons of ABSI and ABSI mortality risk categories with clinical and cardiovascular risk factors were statistically nonsignificant. Patients with below-average BMI (z < 0) (n = 33) were more likely to have above-average ABSI (z > 0) (27.5%) than a below-average ABSI z score (17.5%). Conclusion: These data provide a baseline assessment useful in further studies using larger datasets to confirm whether the ABSI can prove to be clinically useful and serve as a better predictor of mortality risk in the Saudi population. These local data should be of interest to the primary care practitioner who may be thinking of applying these new measures in their primary care practice.
Anticancer properties of green‐synthesised zinc oxide nanoparticles using Hyssopus officinalis extract on prostate carcinoma cells and its effects on testicular damage and spermatogenesis in Balb/C mice

The unclear bio‐safety issue and potential risk of nanoparticles (NPs) on various organelles can be considered as a major challenge. In the present study, we have assessed the green synthesis of ZnO nanoparticles using Hyssop (Hyssopus officinalis) extract and their effects on PC3 cell line and BALB/c mice model. The cytotoxicity of the ZnO‐NPs was assessed on PC3 cell line by MTT test after characterisation. Apoptotic effect of ZnO‐NPs was determined by in vitro AO/PI staining. The histopathological assessments and determination of LH and FSH levels carried out as in vivo analysis in BALB/c adult male mice. The expression of major genes involved in spermatogenesis and sperm maturation (Adam3, Prm1, Spata19, Tnp2, Gpx5) were also analysed. The obtained result demonstrated that the IC50 for PC3 cell line treated with green‐synthesised ZnO‐NPs during 24 and 48 hr was reported 8.07 and 5 µg/ml respectively. Meanwhile, the induced apoptosis was recorded 26.6% ± 0.05, 44% ± 0.12 and 80% ± 0.07 of PC3 cells. The results of gene expression analysis revealed that the increase in the concentration of ZnO‐NPs significantly (p < .05) down‐regulated the Adam3, Prm1, Spata‐19, Tnp2 and Gpx5 genes. The overall results of this research elucidated that ZnO‐NPs impaired spermatogenesis, sperm maturation process and sperm motility.
Chapter 9 The Grail theorem prover : Type theory for syntax and semantics

Type-logical grammars use a foundation of logic and type theory to model natural language. These grammars have been particularly successful giving an account of several well-known phenomena on the syntax-semantics interface, such as quantifier scope and its interaction with other phenomena. This chapter gives a highlevel description of a family of theorem provers designed for grammar development in a variety of modern type-logical grammars. We discuss automated theorem proving for type-logical grammars from the perspective of proof nets, a graph-theoretic way to represent (partial) proofs during proof search.
Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation

Breast cancer (BC) is the most common cancer and second leading cause of cancer mortality in women worldwide. Validated biomarkers enhance efforts for early detection and treatment, which reduce the risk of mortality. Epigenetic signatures have been suggested as good biomarkers for early detection, prognosis and targeted therapy of BC. Here, we highlight studies documenting the modifying effects of dietary fatty acids and obesity on BC biomarkers associated with DNA methylation. We focus our analysis on changes elicited in writers of DNA methylation (i.e., DNA methyltransferases), global DNA methylation and gene‐specific DNA methylation. To provide context, we precede this discussion with a review of the available evidence for an association between BC incidence and both dietary fat consumption and obesity. We also include a review of well‐vetted BC biomarkers related to cytosine‐guanine dinucleotides methylation and how they influence BC risk, prognosis, tumour characteristics and response to treatment.
Cultural Background and Classroom Interaction: Perceptions from American and Brazilian Students.

Positing that an optimal way to make expectations and reality match may lie in helping university faculty learn about cultural traits and perceptions of their foreign students, a'study used G. Hofstede's dimensions of national culture to assess cross-cultural differences in classroom interaction. The research sample was formed by 2 subsamples: 15 Brazilian graduate students and 15 American graduate students attending Penn State University. It was expected that culture background would influence an individual's style of interaction when relating both to classmates and instructors. The assessment of differences in students' perceptions was made by comparing the two groups of students. Except for Hofstede's individualism-collectivism dimension, results indicated that these two groups did not differ significantly. These results contribute to intercultural communication theory and communication education theory. It can help in providing cultural sensitivity and awareness of American educators and teaching assistants regarding behaviors of their students from collectivistic or low context cultures. (Contains 4 tables of data, questionnaire interview sample, and 21 references.) (Author/NKA) ******************************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ******************************************************************************** Q CULTURAL BACKGROUND AND CLASSROOM INTERACTION: PERCEPTIONS FROM AMERICAN AND BRAZILIAN STUDENTS Claudia Ladeira-McCalman PhD Candidate The Pennsylvania State University Speech Communication Department 234 Sparks Building University Park, Pa, 16801 Phone: (814) 867-0717 E-Mail: CXL19@PSUVM.PSU. EDU Fax: (814) 863-7986 U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization originating it. 0 Minor changes have been made to improve reproduction quality. Points of view or opinions stated in this document do not necessarily represent official OERI position cr policy. "PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC). " Paper presented to the Southern States Communication Association convention in New Orleans, Louisiana, April, 1995.
Frequency Injection and Glitch Attack on Ring Oscillator based True Random Number Generators

Random Number Generators (RNGs) are used in various fields such as IoT, Artificial Intelligence, Database, and Information Security in ICT systems. Since RNG is essential in the security industry that applied cryptographic technology, it is especially important to develop high performance RNGs. However, since most of the RNGs are implemented in a physical chip, they can be vulnerable to sidechannel attacks. In this thesis, we make Ring Oscillator (RO) based True Random Number Generators (TRNGs) and perform frequency injection and glitch attack on them. We analyze the abnormal random numbers obtained after the attack and show that the RO based TRNG may not be safe for side-channel attacks. In addition, we present appropriate countermeasures for RO based TRNG to defend against our attacks.
Association between shift work and risk of type 2 diabetes mellitus: a systematic review and dose-response meta-analysis of observational studies

ABSTRACT To evaluate the association between shift work and risk of type 2 diabetes mellitus, we searched PubMed, EMBASE and Web of Science from their inception to June 8, 2019. Observational studies examining the relationship between shift work and type 2 diabetes were included. Subgroup analyses were conducted to explore whether specific characteristics would affect the relationship. A dose-response relationship was estimated by using generalized least squares trend regression. Finally, twelve cohort studies and nine cross-sectional studies were included (inter-rater agreement, k = 0.96). The result of meta-analysis indicated that shift work was associated with an increased risk of type 2 diabetes (relative risk = 1.10, 95% confidence interval = 1.05–1.14). Subgroup analyses demonstrated that female shift workers have increased risk of type 2 diabetes while male not observed, health care workers showed the highest risk compared with civil servants and manual workers, and night shift and rotating shift were associated with an increased risk of type 2 diabetes. Dose-response meta-analysis based on three cohorts among female workers indicated that there might be a positive association between duration of shift work and the risk of type 2 diabetes. In conclusion, shift work is positively associated with an increased risk of type 2 diabetes. Among female workers, with the years of exposure to shift work prolonged, the risk of type 2 diabetes might increase accordingly. In the future, more studies are needed to confirm the results of dose-response analysis.
Venetoclax for the treatment of newly diagnosed acute myeloid leukemia in patients who are ineligible for intensive chemotherapy

Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a globally poor outcome, especially in patients ineligible for intensive chemotherapy. Until recently, therapeutic options for these patients included low-dose cytarabine (LDAC) or the hypomethylating agents (HMA) azacitidine and decitabine, which have historically provided only short-lived and modest benefits. The oral B-cell lymphoma 2 inhibitor, venetoclax, Venetoclax, an oral B-cell lymphoma 2 (BCL2) inhibitor, is now approved by the USA Food and Drug Administration (FDA) in combination with LDAC or HMA in older AML patients ineligible for intensive chemotherapy. Is now approved by the US Food and Drug Administration for this indication. In the pivotal clinical trials evaluating venetoclax either in combination with LDAC or with HMA, the rates of complete remission (CR) plus CR with incomplete hematological recovery were 54% and 67%, respectively and the median overall survival (OS) was 10.4 months and 17.5 months, respectively, comparing favorably with outcomes in clinical trials evaluating single-agent LDAC or HMA. The most common adverse events with venetoclax combinations are gastrointestinal symptoms, which are primarily low grade and easily manageable, and myelosuppression, which may require delays between cycles, granulocyte colony-stimulating factor (G-CSF) administration, or decreased duration of venetoclax administration per cycle. A bone marrow assessment after the first cycle of treatment is critical to determine dosing and timing of subsequent cycles, as most patients will achieve their best response after one cycle. Appropriate prophylactic measures can reduce the risk of venetoclax-induced tumor lysis syndrome. In this review, we present clinical data from the pivotal trials evaluating venetoclax-based combinations in older patients ineligible for intensive chemotherapy, and provide practical recommendations for the prevention and management of adverse events associated with venetoclax.
Challenges in building creativity and innovation into NPD process – results from a case study

Research in NPD has identified a number of organisational practices associated with supporting organisational creativity and innovation including frequent and open communication, cross functional work, building organisational slack, the implementation of high involvement schemes, attitude to risk and top management commitment. Using a single case study approach, this paper explores the challenges associated with the implementation of such organisational practices in the R&D department of a large telecommunication company. Challenges include sequential involvement of functions in the team, broken communication between different teams, management attitude to resource constraints, short term pressures due to dynamic market, and limited management support for the implementation of idea generation schemes.
Towards integration of methodologies for assessing and promoting the societal embedding of energy innovations

The necessity for system innovation is well acknowledged, but inducing system change proves to be very difficult. Three approaches have been developed for analysing and supporting radical innovations: Socrobust, Create Acceptance and Strategic Niche Management. This paper gives an overview of these complementary approaches and their theoretical background. The paper also identifies several potential contributions for social scientists to contribute to energy research and the implementation of more sustainable alternatives.
Dietary composition and yeast/microalgae combination supplementation modulate the microbial ecosystem in the caecum, colon and faeces of horses

Abstract Starchy diets can induce hindgut dysbiosis in horses. The present study evaluated the impact of a yeast (Saccharomyces cerevisiae) and microalgae (Aurantiochytrium limacinum) supplementation on caecal, colonic and faecal microbial ecosystem and on blood inflammatory parameters of horses fed high-fibre or high-starch diets. Six fistulated geldings in a 2 × 2 Latin-square design were alternatively supplemented and received during each period 100 % hay (4 weeks) followed by a 56/44 hay/barley diet (3 weeks). Caecal, colonic and faecal samples were collected 4 h after the morning meal three times per diet, at 5-d intervals, to measure bacterial composition and microbial end products. Blood was simultaneously collected for measuring inflammatory markers. The starchy diet clearly modified the microbial ecosystem in the three digestive segments, with an increase of the amylolytic function and a decrease of the fibrolytic one. However, no effect of the diet was observed on the blood parameters. When horses were supplemented, no significant change was found in lipopolysaccharides, PG-E2, serum amyloid A concentrations and complete blood count neither in cellulose-utilising, starch-utilising and lactate-utilising bacteria concentrations nor in the volatile fatty acids and lactate concentrations and pH. Under supplementation, relative abundance of Family XIII Clostridiales increased in caecum and faeces irrespective of diet and relative abundance of Veillonellaceae was higher during the hay/barley diet in colon and faeces. Most variations of faecal bacterial taxa under supplementation were not observed in the hindgut. However, all variations suggested that supplementation could increase fibrolytic function whatever the diet and limit dysbiosis when the horses’ diet changed from high fibre to high starch.
Reduced Levels of chloroquine resistant Plasmodium falciparum in selected foci of the South West Province, Cameroon

Objectives: To evaluate the state of chloroquine resistant malaria in the South West Province of Cameroon. To estimate the prevalence of different species of Plasmodium in the area. Design: A cross' sectional study. Cent AfrJ Med 2001;47(6): 145-9 *Department of Life Sciences University of Buea South West Province Cameroon **Biotechnology Centre University of Yaounde 1 Yaounde Cameroon Correspondence to: Dr Theresa Nkuo-Akenji Department of Life Sciences University of Buea P O Box 63 Buea South West Province Cameroon Cent AfrJ Med 2001;47(6) 145
Performance of Laying Hens Fed Graded Levels of Soaked Sesame (Sesamum indicum) Seed Meal as a Source of Methionine

In a 12 week experiment the effect of graded levels of soaked sesame seed meal (SSM) as a source of methionine on the performance of laying hens was investigated. In a completely randomized design, 200 black Australorp pullets aged 20 weeks were allotted to 5 isonitrogenous diets with 4 replicates of 10 birds per diet. Sesame seed meal (SSM) replaced soyabean meal (SBM) weight for weight at 0.00, 12.50, 37.50 and 50.00% in diet 1 (control), 2, 3, 4 and 5 respectively. The control diet contained synthetic methionine which was removed with the introduction of SSM in the other diets. The results showed a significant (P 0.05) on the while blood cell count, but packed cell volume was significantly (P<0.05) lowered on the 50.00% and haemoglobin concentration, serum protein, albumin and globulin above 12.50% levels of replacement. These results suggest that replacing SBM with SSM at 12.50% in the diet of laying hens will meet their methionine requirement without adverse effects on performance and health status.
Detection of Coniferous Seedlings in UAV Imagery

Rapid assessment of forest regeneration using unmanned aerial vehicles (UAVs) is likely to decrease the cost of establishment surveys in a variety of resource industries. This research tests the feasibility of using UAVs to rapidly identify coniferous seedlings in replanted forest-harvest areas in Alberta, Canada. In developing our protocols, we gave special consideration to creating a workflow that could perform in an operational context, avoiding comprehensive wall-to-wall surveys and complex photogrammetric processing in favor of an efficient sampling-based approach, consumer-grade cameras, and straightforward image handling. Using simple spectral decision rules from a red, green, and blue (RGB) camera, we documented a seedling detection rate of 75.8 % (n = 149), on the basis of independent test data. While moderate imbalances between the omission and commission errors suggest that our workflow has a tendency to underestimate the seedling density in a harvest block, the plot-level associations with ground surveys were very high (Pearson’s r = 0.98; n = 14). Our results were promising enough to suggest that UAVs can be used to detect coniferous seedlings in an operational capacity with standard RGB cameras alone, although our workflow relies on seasonal leaf-off windows where seedlings are visible and spectrally distinct from their surroundings. In addition, the differential errors between the pine seedlings and spruce seedlings suggest that operational workflows could benefit from multiple decision rules designed to handle diversity in species and other sources of spectral variability.
Preliminary Report on the Effect of Ketamine in Patients with Central Pain

This preliminary open prospective study reports on the effect of ketamine, an N-methyl-D-aspartate (NMDA)-receptor noncompetitive antagonist, in five patients suffering from central poststroke pain (CPSP). Patients were evaluated at rest on a visual analogue scale (VAS) graded from 0 to 10. Pain measurement was repeated at 15 and 30 mins following intravenous administration of 0.15 to 0.25 mg/kg ketamine and then every 30 mins for 6 h. Pain evoked by light touch or cold stimulation was also measured in three patients at those times. Patients were monitored for arterial pressure, heart rate, sedation and side effects during the study. Ketamine provided a significant improvement in pain at rest and in evoked pain. A 51% to 84% decrease in the VAS score for pain at rest was observed within 60 to 180 mins. Satisfactory pain relief (more than 50% decrease in the VAS score) lasted for 150 to 210 mins. Two patients had a prolonged improvement over two or three days. Arterial pressure and heart rate did not change significantly. Mild or moderate sedation was noticed in all patients for 20 to 30 mins. These results suggest that blockade of NMDA receptors may provide pain relief in patients suffering from CPSP.