Miracle-dz/UniFAR-FTUs huggingface dataset:
Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

The current study was aimed at evaluating the antihyperalgesic effects of lignans (phyllanthin and hypophyllanthin) and tannin (corilagin) rich three standardized extracts of Phyllanthus amarus in a model of chronic musculoskeletal inflammatory pain. Three percent carrageenan injected in the gastrocnemius muscle produced hyperalgesia to mechanical and heat stimuli ipsilaterally, which spreads to the contralateral side within 7 to 9 days. To investigate the effects on chronic thermal and mechanical hypersensitivity, three extracts of P. amarus in three doses (100, 200, and 400 mg/kg) were administered to animals intraperitoneally from 14th day to 22nd day after intramuscular injection of carrageenan. It was observed that intraperitoneal administrations of Phyllanthus extracts showed antihyperalgesic activity, as they elevated thermal and mechanical threshold, which was supported by histopathological observations along with reduction in prostaglandin E2 (PGE2) concentration. In conclusion, we strongly suggest that the observed antihyperalgesic and antiinflammatory effects of P. amarus in current pain model are mediated via spinal or supraspinal neuronal mechanisms, mainly by inhibition of PGE2. Modulation of chronic muscular inflammation may be due to presence of phytoconstituents like phyllanthin, hypophyllanthin, and corilagin, which offers a promising means for treatment of chronic muscle pain. Copyright © 2015 John Wiley & Sons, Ltd.
Characterization of ompF domains involved in Escherichia coli K-12 sensitivity to colicins A and N

Various ompF-ompC, ompC-ompF, and ompF-ompC-ompF chimeric genes were used to locate the domains of the OmpF protein involved in cellular sensitivity to colicins. Various parts of the porin participate in the entry of colicins. Colicin N receptor activity was found to require three regions: RN1, located between residues 1 and 63; RN2, located between residues 115 and 262; and RN3, located between residues 279 and 297. The central domain from residues 143 to 262 is involved during the translocation step after the binding step. A large region, including residues 1 to 262, is necessary during colicin A entry. The locations and interactions between these domains specifically required for the uptake of colicins to occur are described and discussed with regard to the homology and topology of the OmpC, OmpF, and PhoE porins.
Effectiveness of mindfulness‐based cognitive therapy as an adjuvant to pharmacotherapy in patients with panic disorder or generalized anxiety disorder

Background: Mindfulness‐based cognitive therapy (MBCT) has been widely used to treat patients with depressive disorder to prevent relapse. The objective of this study was to examine the effectiveness of newly developed MBCT program as an adjuvant to pharmacotherapy in the treatment of patients with panic disorder or generalized anxiety disorder. Methods: Forty‐six patients with panic disorder or generalized anxiety disorder were assigned to either MBCT or an anxiety disorder education (ADE) program for a period of 8 weeks. The Hamilton Anxiety Rating Scale (HAM‐A), Hamilton Depression Rating Scale (HAM‐D), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Symptom Checklist‐90‐Revised (SCL‐90‐R) were used to assess the patients at 0 week and after the two programs had been running for 2, 4, and 8 weeks. Results: The MBCT group demonstrated significantly more improvement than the ADE group according to all anxiety (HAM‐A, p<0.01; BAI, p<0.01; anxiety subscale of SCL‐90‐R, p=0.01) and depression (HAM‐D, p<0.01; BDI, p<0.01; depression subscale of SCL‐90‐R, p<0.01) scale scores. The obsessive‐compulsive and phobic subscales of the SCL‐90‐R also showed significantly more improvement in the MBCT group. However, no significant improvement was observed in the MBCT group versus the ADE group in terms of the somatization, interpersonal sensitivity, paranoid ideation, or psychoticism subscale scores of the SCL‐90‐R. Conclusions: MBCT may be effective at relieving anxiety and depressive symptoms in patients with panic disorder or generalized anxiety disorder. However, well‐designed, randomized controlled trials are needed. Depression and Anxiety, 2009. © 2009 Wiley‐Liss, Inc.
` 1 Regression using Lewis Weights Preconditioning

We consider the `1 minimization problem minx ‖Ax − b‖1 in the overconstrained case, commonly known as the Least Absolute Deviations problem, where there are far more constraints than variables. More specifically, we have A ∈ Rn×d for n d. Many important combinatorial problems, such as minimum cut and shortest path, can be formulated as `1 regression problems [CMMP13]. We follow the general paradigm of preconditioning the matrix and solving the resulting problem with gradient descent techniques, and our primary insight will be that these methods are actually interdependent in the context of this problem. The key idea will be that preconditioning from [CP15] allows us to obtain an isotropic matrix with fewer rows and strong upper bounds on all row norms. We leverage these conditions to find a careful initialization, which we use along with smoothing reductions in [AH16] and the accelerated stochastic gradient descent algorithms in [All17] to achieve relative error in about nnz(A)+ndω−1+ √ nd −1 time with high probability. Moreover, we can also assume n ≤ O(d −2 log n) from preconditioning. This improves over the previous best result using gradient descent for `1 regression [YCRM16], and is comparable to the best known running times for interior point methods [LS15]. Finally, we also show that if our original matrix A is approximately isotropic and the row norms are approximately equal, we can avoid using fast matrix multiplication and prove a running time of about nnz(A)+sd −2 +d −2, where s is the maximum number of non-zeros in a row of A. ∗Georgia Institute of Technology. email:ddurfee@gatech.edu †Georgia Institute of Technology. email:kevinlai@gatech.edu ‡Georgia Institute of Technology. email:sawlani@gatech.edu
Communication in palliative care: talking about the end of life, before the end of life

Increasing evidence demonstrates the benefits of early end-of-life care discussions with patients with life-threatening illness and their families. However, these conversations often do not occur. This review explores some of the many barriers faced by clinicians in relation to end-of-life care discussions, including prognostic uncertainty, fear of causing distress, navigating patient readiness and feeling unprepared for these conversations. The value of core clinical communication skills, potential strategies for improvement and areas for future research are also discussed. It is essential that clinicians offer patients facing life-threatening illness, and those close to them, the opportunity to discuss end-of-life issues in line with their information and decision-making preferences. With a growing and ageing global population, supporting both generalist and specialist providers of palliative care in this task is key. With careful preparation, fears of undertaking these discussions should not be a barrier to initiating them.
Immunohistochemical Localization of Angiotensin-Converting Enzyme, Angiotensin II and AT1 Receptor in Human Ocular Tissues

We investigated the immunohistochemical distribution of 3 components of the renin-angiotensin system (RAS), angiotensin-converting enzyme (ACE), angiotensin II (AngII) and AT1 receptor (AT1), in the human eye. ACE and AngII were localized to nonpigmented epithelial cells of the ciliary body, to endothelial and epithelial cells of the cornea, to epithelial cells of the conjunctiva and to trabecular meshwork cells in the anterior part of the eye. In the posterior part of the eye, ACE and AngII were localized to ganglion cells, some cells in the inner nuclear layer, photoreceptor cells and to endothelial cells of the retinal and choroidal vessels. The overall intensity of AT1 immunoreactivity was weak in all ocular tissues, but the main localization was in ganglion cells. As a preliminary investigation, we were able to include 2 Alzheimer’s disease (AD) cases. In AD, no differences from controls were found in the cellular distribution and staining intensity of all 3 antigens. The manifold localization sites of the observed antigens point to rather generalized functions of the RAS in human ocular tissues, such as regulatory effects on neuronal cells, vessels and vitreous humor homeostasis.
XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: A meta‐analysis

Several studies have investigated the associations between X‐ray repair cross‐complementing group 3 (XRCC3) Thr241Met polymorphism and the susceptibility to lung cancer and bladder cancer, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta‐analysis was performed. A total of 22 case control studies, including 2976 cases and 4495 controls for lung cancer, and 3445 cases and 4599 controls for bladder cancer, met the inclusion criteria and were selected. Overall, there was no evidence showing a significant association between XRCC3 Thr241Met polymorphism and lung cancer risk. Furthermore, the results for bladder cancer showed that significant decreased risk was found for the additive model (odds ratio [OR] = 0.959, 95% confidence interval [CI], 0.924–0.996) and dominant model (OR = 0.982, 95% CI, 0.963–1.000) but not for the recessive model (OR = 0.958, 95% CI, 0.905–1.014). In summary, our meta‐analysis indicates that XRCC3 Thr241Met polymorphism may be weakly associated with the risk of bladder cancer. (Cancer Sci 2010)
The Winner's Curse

We extend a model developed by Evans and Jovanovic (1989) to explain when start-ups are credit con- strained. We show that the magnitude of the credit constraint is conditioned by the relative productivity of human capital in both wage work and self-employment. The effect of pre- dicted household income on start-up capital is used to indicate the existence of financial constraint. Empirical analysis reveals that entrepreneurs with high human capital have both greater financial wealth and greater levels of start-up capital pointing to the endogenous nature of credit constraints. High human capital relaxes financial constraints, apparently due to greater productivity of human capital in wage work than in self- employment. Those who are the least likely to be credit con- strained in self-employment are those that are least likely to switch into self-employment, and vice versa.
Applicants' likelihood to apply for jobs at professional service firms: The role of different career models

Against the backdrop of only a few empirical studies on the topic of up-or-out career models in Professional Service Firms, we highlight the importance of an explicit applicant perspective on the topic of up-or-out and develop a quantitative approach to analyze the perception and effects of up-or-out models in practice. Our empirical study is based on an online practitioner survey as well as on a two-by-two between-subjects-experiment with law and management students. The practitioner sample shows that the interviewed classic PSFs (law firms and accounting firms) have predominantly implemented alternative career positions in favor of up-or-out models while the interviewed Neo-PSFs (consulting firms) show a more balanced implementation of up-or-out models and extended career models. However, results of our experimental applicant study reveal that the potential employee groups have different preferences: Law students (and hence potential applicants of classic PSFs in the future) show a higher likelihood to apply in connection with the up-or-out-model, whereas management students (and hence potential applicants of Neo-PSFs in the future) show a higher likelihood to apply in connection with the alternative career model.
Relationship between examination questions and bloom's taxonomy

Written examination is a conventional yet universal tool to evaluate the student's performance in a subject area, where the required cognitive ability is defined through items such as learning outcomes. Whether or not the written examination is able to assess the student's ability very much depends on the questions presented in the examination paper. A good and reasonable examination paper must consist of various difficulty levels to accommodate the different capabilities of students. In this work, the difficulty level of each question in the examination paper is determined from the criteria of keyword/s found in the question. Further, the paper presents the cross-analysis across student performance, cognitive skill requirements, and module learning outcomes. The paper provides conclusions on the current relationship between examination questions, learning outcomes and student performance, as well as providing some indication of the relative changes required to move toward a more appropriate association and hence improve an assessment strategy.
Perinatal Mental Health

Pregnancy is the time during which physiological and psychological preparation for motherhood takes place. It has long been considered a blessed time, free of psychiatric disorders. However, there is now strong evidence that major depressive disorder may occur not only after birth but even during the prepartum. Most often, mental illness during this period is underestimated, not assessed, therefore not diagnosed, and consequently goes untreated. Reviewing the literature on the negative impact of both maternal and infant health in case of perinatal depression, we underline that recognizing and treating prenatal depression will lead to preventive and curative treatments for mothers, enhance infant health, and therefore positively influence mother-infant relationships.
Dynamic Privacy-Preserving Genomic Susceptibility Testing

The field of genomic research has considerably grown in the recent years due to the unprecedented advances brought about by Next Generation Sequencing (NGS) and the need and increasing widespread use of outsourced processing. But this rapid increase also poses severe privacy risks due to the inherently sensitive nature of genomic information. In this work, we address privacy-preserving genetic susceptibility tests outsourced to an untrustworthy party, enhancing previous approaches in terms of computation and communication efficiency by leveraging the use of somewhat homomorphic lattice encryption and relinearization operations to achieve more efficient constructions. Additionally, we also propose a more general construction which deals with several different medical units (such as pharmaceutical companies or hospitals), managing patients' consent to the disclosure of test results for each of these units, which may dynamically join the system. Our scheme features an attribute-based homomorphic cryptosystem which enables enforcing the patient's access policy referred to the different medical units.
Business and Accounting Studentsâ€™ Perceptions on Industrial Internship Program

Internship programme is one of the methods which will expose students a chance to gain a deeper understanding of the knowledge that they have learned in the classrooms through actual works experience in the industry. Normally, before a student graduates, he/she has to undergo this industrial internship programme. The objective of this study is to examine business and accounting studentsâ€™ opinions on industrial internship programme by using a survey instruments which consists of 18 statements. The statements were grouped into four dimensions: Career; Knowledge and Practical Experience; Soft Skills; and Monetary and Non Monetary Incentives. The survey was conducted by using four point-likert scale and distributed to 33 business and 51 accounting students at University Sultan Zainal Abidin, Malaysia. The results indicate that both business and accounting students emphasise on Career as the most important dimension. Next of importance are Soft Skills, Knowledge and Practical Experience, and Monetary and Non Monetary Incentives. The results also indicate that both business and accounting students have similar opinions regarding industrial internship programme.
Post‐crucial Period Effects of Auditory Experience and Deprivation on the Guinea‐pig Superior Collicular Map of Auditory Space

The auditory space map in the superior colliculus of the guinea‐pig requires for its normal emergence at 32 days after birth (DAB) bimodal, auditory and visual experience during a 4‐day crucial period (26–30 DAB) (Withington‐Wray et al., Neurosci. Lett., 116, 280–286, 1990d). The need for auditory experience has been proposed to be linked to the rapid changes in the cues for auditory localization brought about by head growth. Head growth is particularly rapid during the first postnatal month but continues more slowly until ∼70 DAB. This suggests that sensory experience may be required beyond the initial crucial period to accommodate later growth. In this paper the role of auditory experience beyond the crucial period has been investigated. Deprivation of ordinary auditory experience was effected by placement of the animals in an environment in which continuous omnidirectional noise obscured the cues of sound direction. Animals deprived of auditory experience during the crucial period and then allowed normal experience showed limited ability to construct an auditory space map and the resulting map was less accurate than that found in normally reared animals. Auditory deprivation following normal experience during the crucial period caused a profound degradation, of both spatial tuning and topography, of auditory multi‐unit receptive fields in the superior colliculus. The spatial tuning and topography of auditory fields from older animals (100 DAB) deprived of ordinary auditory cues for a 4‐week period were normal. Thus, in the guinea‐pig, susceptibility of the superior collicular space map to deprivation of auditory cues is limited by the age of the animal. The timing of the cessation of vulnerability may, in part, be due to the stabilization of directional cues affected by head growth.
Asset price formation and behavioral biases

Purpose The purpose of this paper is to examine the debate on whether psychology affects asset prices using agent-based modeling. Design/methodology/approach The authors set up three simulation regimes where the first regime contains fundamental investors who invest based on the mean-variance framework. The second regime includes purely irrational investors who invest based on behavioral biases. The third regime combines the two types of investors. The authors test whether the return properties from regime 3 converge to that of regime 1 or 2. Findings Results suggest that the type of irrationality affects return properties in different ways. Irrational investors who are introspective in their irrationality, only examining their performance and deficiencies, do not have much of a systematic effect on stock returns when combined with rational investors. However, irrational investors that aggregate information in an irrational manner have a systematic effect when combined with rational investors. Research limitations/implications Research implication of using simulation analysis is that the results need to be verified via other methods such as empirical and/or experimental analysis. Practical implications Practical implications of the research is that policy makers can look for factors that investors use to aggregate to better understand the movement of financial prices and ignore other factors. Social implications Social implication is that mass psychology impacts financial prices. Originality/value No other paper has used agent-based/behavioral analysis to better understand how different types of behavior may impact financial prices in different ways.
[Peritoneal puncture dialysis in the monitoring and treatment of hemoperitoneum of traumatic origin?].

The great diversity of injuries after abdominal wound, need an adapted treatment. When laparotomy is indicated in uncontrollable hemorrhage, peritoneal lavage associated with C.T. scan seems to be interesting in the management of hemoperitoneum with a moderate injury severity score and stable arterial and venous pressures. Three patients were recently managed non operatively with good results. The authors draw up these three cases with inclusion criterias and limits of the method.
Investment coordinates in the context of housing and stock markets nexus

ABSTRACT This study examines the causal relationship between Chinese housing market (HM) and stock market (SM), using the bootstrap Granger full-sample causality test and subsample rolling-window estimation test. The results show that stock price (SP) has both positive and negative impacts on housing price (HP) in several sub-periods, and HP has the same effects on SP. The substitution effect drives their adverse consequences. Meanwhile, the positive effect indicates that SP has a wealth effect on HP, and HP has a credit-price effect on SP. Results provide information to Chinese financial institutions and individual investors for constructing investment portfolios within these asset markets.
Engaging Health Care Consumers to Improve the Quality of Care

Background.Researchers and policy makers have focused on informed choice as the primary role for consumers in improving care. Consumers may play two other roles in improving quality—by being active participants in their care (coproducer role) and by evaluating the care they receive (evaluator role). Enhancing the roles consumers are able to play in the health care system may significantly increase their influence on quality. Objectives.To examine the evidence available on the contribution of consumers to quality through the coproducer and evaluator roles. Research Design.Conceptual framework and review of the literature. Findings.Patients who engage in collaborative care, shared decision-making with their providers, and chronic disease self-management have improved health outcomes. Training patients with chronic diseases to self-manage their disease increases functioning, reduces pain, and decreases costs. Developing the evaluator role will support and increase the effectiveness of the other two roles—the informed choice role and the coproducer role. Conclusions.Only the informed choice role is being actively promoted for consumers. Increasing the coproducer role would require system and provider change, as well as an increase in consumers’ skills and knowledge and a change in their understanding of their appropriate role. Harnessing the power of consumers to create change will depend on the degree to which all these roles are encouraged and supported.
Missing Consumption Inequality: Direct Evidence from Individual Food Data

Without data on individual consumption, inequality across individuals is almost invariably inferred by applying adult equivalence scales to household-level consumption data. To assess whether these household-based measures are effective, we exploit a rare opportunity in which individual food consumption data for each and all household members are available. We use a large sample of eight waves of the China Health and Nutrition Survey 1991-2011 that cover roughly 4,000 households and 11,000 individuals per wave. We find that adult-equivalent consumption misses 40% of the total cross-sectional individual inequality. The missing inequality is largely driven by the “vices" (i.e. alcohol, tobacco, coffee and tea) and by the core food consumption of young children. Our results suggest caution in the use of adult-equivalent scales to measure inequality, whose effectiveness depends on the items in the consumption basket and the presence of young children.