Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship of Serum Vitamin D levels with Nerve Conduction Velocity in patients of Diabetic Neuropathy

Introduction: Although vitamin D insufficiency is very prevalent in Type-2 diabetes mellitus, there are no studies to prove its role or association in diabetic peripheral neuropathy. Aims and Objectives: We intend to highlight the relationship of Serum Vitamin D levels with Nerve Conduction Velocity in patients of Diabetic Peripheral Neuropathy. Material and Methods: 52 patients of diabetic neuropathy were assessed for sensory and motor nerve conduction velocity along with serum Vitamin D levels estimation and the results were statistically analyzed. Results: Tingling was the most common symptom, seen in 31.1% cases. The numbers of nerve involvement increased with the duration of diabetes mellitus. Majority of the patients showed decrease in SNCV and MNCV in more than three nerves,17(32.69%) and 15(28.84%) cases. 14(87.5%) vitamin D deficient patients had HbA1c levels >11.5. Vitamin D deficiency was more pronounced than insufficiency as the HbA1c levels got increased. The vitamin D deficiency increased in proportion to the duration of disease, with maximum number of vitamin D deficient patients in the disease duration of 11-15 years followed by vitamin D deficient patients with duration of disease>15 years. 36(69.2%) of the diabetic patients were deficient in vitamin D, followed by vitamin D insufficiency in 14(26.9%) (p value Conclusions: Nerve conduction velocities and vitamin D deficiency might be independently associated with diabetic peripheral neuropathy, so these investigative parameters could be used as an independent marker to assess the severity of the neuropathy. Keywords: Diabetes, Peripheral Neuropathy, Nerve Conduction Velocity, Vitamin D.
Antitubercular Potential of Novel Isoxazole Encompassed 1, 2, 4- Triazoles: Design, Synthesis, Molecular Docking Study and Evaluation of Antitubercular Activity

Decaprenylphosphoryl-β-D-ribose epimerase (DprE1), a flavoprotein enzyme engaged in the biosynthesis of decaprenylphosphoryl-β-D-arabinofuranose (DPA), is the only contributor of arabinose residues which is fundamental for the mycobacterium cell wall constituents. DprE1 is an interesting target for antitubercular agent and has been exploring to develop potential chemical entities as antitubercular agents. The objective of the study is the development of novel antitubercular agents targeting Mtb Decaprenylphosphoryl-β-D-ribose epimerase (DprE1). A series of isoxazole encompassed 1, 2, 4-triazoles were designed based on the antitubercular potential of triazoles and structural features of DprE1 inhibitors. Designed 1, 2, 4- triazoles were synthesized and characterized by spectral studies. The in vitro anti-TB activity of the compounds was screened against Mycobacterium tuberculosis H37Rv strain by Microplate Almar Blue Assay and in vitro cytotoxicity against normal cell lines by MTT assay. Molecular docking study was carried out on DprE1 enzyme to understand designed compounds interactions with amino acid residues at the active site. Antitubercular activity data revealed that eight compounds (6d, 6e,7d, 7e, 10d, 10e, 11d and 11e) have shown promising antitubercular activity with minimum inhibitory concentration at 1. 6μg/mL. Cytotoxicity data of anti-TB active compounds demonstrate good safety profile on normal cell lines. Eight compounds have shown promising antitubercular activity with good safety profile on normal cell lines. Molecular docking study revealed that the synthesized compounds have shown non-covalent interactions with amino acid residues of DprE1 enzyme.
Modelling of viscoacoustic wave propagation in transversely isotropic media using decoupled fractional Laplacians

A new wave equation is derived for modelling viscoacoustic wave propagation in transversely isotropic media under acoustic transverse isotropy approximation. The formulas expressed by fractional Laplacian operators can well model the constant‐Q (i.e. frequency‐independent quality factor) attenuation, anisotropic attenuation, decoupled amplitude loss and velocity dispersion behaviours. The proposed viscoacoustic anisotropic equation can keep consistent velocity and attenuation anisotropy effects with that of qP‐wave in the constant‐Q viscoelastic anisotropic theory. For numerical simulations, the staggered‐grid pseudo‐spectral method is implemented to solve the velocity–stress formulation of wave equation in the time domain. The constant fractional‐order Laplacian approximation method is used to cope with spatial variable‐order fractional Laplacians for efficient modelling in heterogeneous velocity and Q media. Simulation results for a homogeneous model show the decoupling of velocity dispersion and amplitude loss effects of the constant‐Q equation, and illustrate the influence of anisotropic attenuation on seismic wavefields. The modelling example of a layered model illustrates the accuracy of the constant fractional‐order Laplacian approximation method. Finally, the Hess vertical transversely isotropic model is used to validate the applicability of the formulation and algorithm for heterogeneous media.
Congenital Melanocytic Hairy Nevi in a Child from North-Western Nigeria

Aim: To present the first report of a large congenital melanocytic nevus with satellite nevi in an apparently healthy child from Sokoto, North-Western Nigeria. Presentation of Case: A three year old girl was brought to the paediatric out-patient clinic of Paediatrics department of Usmanu Danfodiyo University Teaching Hospital (UDUTH) Sokoto with complaints of darkened skin colour on the left side of the face and scalp, the left arm, lower back, buttocks, and thighs, and excessive hair growth over the same side of the face since birth. There were no neurological symptoms Physical examination findings revealed a well-nourished, not ill looking child. She had a hyper pigmented patch on the left side of the face extending from the lower jaw to the scalp, measuring 21 cm in its longest length, with hypertrichosis on the same site, and two distinct, firm, painless nodular lesions on the left temporal region measuring 3 mm and Case Study Jiya et al.; AJMAH, 18(7): 28-34, 2020; Article no.AJMAH. 58294 29 4mm respectively. On the lower one-third of the left arm was a hairy, velvety area of hyperpigmentation measuring 2X3 cm in diameter. Other affected sites were the lower back, the gluteal region and the thighs. Her neurologic and other systemic examinations were normal. A diagnosis of large congenital facial melanocytic hairy nevus with multiple satellite nevi was made. Discussion: Congenital melanocytic nevi are benign proliferations of melanocytic cells said to be present at birth or in the first two years of life. Large lesions are rare, they measure 20 cm or more and are said to occur more commonly on the trunk and thighs. The exact pathogenesis of congenital melanocytic nevi is yet, unknown. It is thought to occur as a result of a morphological error in the neuroectoderm during embryogenesis. Treatment of patients with large congenital melanocytic nevus may include surgical or non-surgical procedures as well as psychological interventions. Large lesions, multiple satellite lesions or paravertebral and axial locations are sometimes associated with the risk of neurological complications and malignant transformation. Conclusion: Large congenital melanocytic nevi are uncommon skin lesions that can occur in apparently healthy children. Individualization of the patients with regards to treatment options and long term monitoring are imperative.
Competitive Priorities, Employee Management and Development and Sustainable Manufacturing Performance in Asian Organizations

This study investigates the relationships between three dimensions of competitive priorities (customer focus, product innovation and delivery) and how Asian manufacturers manage and develop their employees and the consequent effect on sustainable manufacturing performance. Three dimensions of manufacturing performance are considered in this study—quality performance, production flexibility and operations cost. This study uses 259 datasets collected from manufacturers in four Asian countries. Structural equation modeling and mediation analysis are performed to test the relationships. Results show that there is a significant positive and mediating relationship between the competitive priority of product innovation, employee management and development, quality performance, production flexibility and operation cost. However, such significant relationships do not exist with competitive priorities of customer focus and delivery. Organizations are constantly faced with the problem of determining which competitive priorities to focus on. However, different competitive priorities have different effects on how the employees are managed and developed, and ultimately, on organizational performance and competitiveness. There is a need to focus on innovation-led strategies that relate to sustainable outcomes. This is one of the first studies in Asia to understand the multilateral relationships between different competitive priorities and different performance dimensions when employee management and development intermediate.
Ex Vivo Modelling of Therapy Efficacy for Rare Krukenberg Tumors – A Report of Two Cases

Krukenberg tumor (KT) is a rare subtype of ovarian neoplasms that manifests as secondary ovarian cancer. Most frequently, KTs originate from a primary in the gastrointestinal tract and account for 30 to 40% of all secondary ovarian cancers. A key histologic characteristic finding used in the diagnosis of KT is the presence of mucin-laden signet-ring cells. Bilateral metastasis into both ovaries has been reported in more than 80% of KTs, and a significant fraction of these cases are reported to receive no survival benefit from chemotherapy. Despite clinical evaluation of several chemotherapeutic treatments for the management of KT, the general prognosis of the disease is poor and radical surgery remains the main treatment shown to improve the overall survival. As no targeted therapies have been reported for KT, we performed an ex vivo drug screen to assess the efficacy of targeted therapeutics with patient-derived Krukenberg tumor cells. Tumor cells isolated from a coarse needle biopsy and tumor-associated immune cells derived from malignant ascites effusion from two patients with a gastric cancer derived KT were used for the analysis of responses to 120 drugs. A comparison of the results showed that tumor cells from both patients showed systematic sensitivity toward topoisomerase inhibition, epigenetic modulators, statins and alkaloid tubulin inhibitors. Ascites-derived immune cells displayed selective sensitivity to a number of targeted agents, including VEGFR inhibitor sunitinib. Flow cytometry analysis identified the effect of sunitinib to be immunomodulatory and targeted on the immunosuppressive M2 type macrophages. The immunomodulatory effect of sunitinib was confirmed from analysis of the patient ascites following treatment and was accompanied by sustained clinical response. These results support the concept of harnessing the immunomodulatory effects of VEGFR-TKI for cancer therapy and suggest further analysis also in the context of Krukenberg tumors.
Analysis of the Thermoelastic Damping Effect in Electrostatically Actuated MEMS Resonators

An important aspect that must be considered when designing micro-electro-mechanical systems (MEMS) for all domains, including robotics, is the thermoelastic damping which occurs when the MEMS material is subjected to cyclic stress. This paper is focused on a model for the thermoelastic damping developed based on the generalized thermoelastic theory with the non-Fourier thermal conduction equation. The model was implemented in MATLAB and several simulations were performed. The theoretical results show a decrease in the deflection amplitude with the increase in time. The deflection amplitude decrease was validated by the experimental investigations, consisting of measuring the loss in amplitude and velocity of oscillations as a function of time. Moreover, this paper also presents the influence of the geometric dimensions on the mentioned decrease, as well as on the initial and final values of the amplitude for several polysilicon resonators investigated in this paper.
Research on Energy-Saving Wind Turbine Blade Based on Advanced Fluid Mechanics Technology

The aerodynamic performance of wind turbine blades is of great significance and value to the power output of wind turbines. Correct evaluation of blade performance is beneficial to the design and design of wind turbines. In the operating environment, the aerodynamic load on the blade is a combination of the aerodynamic pressure of the air and the additional force generated by its own rotation. Under different environmental conditions, the aerodynamic load on the wind turbine blades will be significantly different. Using advanced fluid mechanics, the developed program is used to perform aerodynamic simulation on a certain type of wind turbine blade calculation example to obtain the flow field and blade surface pressure coefficient distribution. The calculated results are in good agreement with the experiment, and the developed program can be used for aerodynamic analysis of engineering wind turbine blades, which is conducive to the development of wind turbine design.
Growth and chemical characterisation studies of Mn silicate barrier layers on SiO2 and CDO

This thesis investigates the suitability of manganese silicate (MnSiO3) as a possible copper interconnect diffusion barrier layer on both a 5.4 nm thick thermally grown SiO2 and a low dielectric constant carbon doped oxide (CDO), with the focus of understanding the barrier formation process. The self forming nature of this diffusion barrier layer resulting from the chemical interaction of deposited Mn with the insulating substrate has potential application in future generations of copper interconnect technologies as they are significantly thinner than the conventional deposited barrier layers. The principle technique used to study the interface chemistry resulting from the interaction of deposited manganese with the insulating substrates to form a MnSiO3 layer was x-ray photoelectron spectroscopy (XPS). Transmission electron microscopy (TEM) measurements provided information on the structure of the barrier layers which could be correlated with the XPS results. Significant differences in the extent of the interface interaction which resulted in the formation of the MnSiO3 barrier layer were found to depend on whether the deposited Mn was partially oxidised. The studies performed on the 5.4 nm thermally grown SiO2 confirmed that the growth of the MnSiO3 resulted in a corresponding reduction in the SiO2 layer thickness. Interactions between residual metallic Mn and subsequently deposited copper layers were also investigated and showed that in order to reduce the width of the barrier layer, it was preferable that all the deposited Mn was fully incorporated into the silicate. TEM measurements were also used to investigate thicker thermally deposited Mn/Cu heterostructures on SiO2 which were subsequently annealed in order to study the diffusion interactions between copper and manganese. The formation of Mn silicate layers on low dielectric constant carbon doped oxide (CDO) was also investigated and compared with the formation characteristics on the thermally grown SiO2.
European database of the life-history, morphological and habitat characteristics of dragonflies (Odonata)

Climate change and an ever-increasing effect of humans on the great majority of freshwater ecosystems have affected not only individual organisms but also the links between them. In order to effectively protect communities or entire freshwater ecosystems, we need to understand how individual organisms react to these changes and the functional interconnections between individual species. This can be achieved by evaluating the functioning of individual species, i.e. their traits. Dragonflies and damselflies are increasingly used as indicators of changes in freshwater ecosystems. Although this taxonomic group is the subject of many ecological studies, there is no comprehensive database of the traits of European species. This is, why we decided to lay the foundations for an European database of dragonfly traits called dragonfly-database.eu, which is mainly based on Web of Science (WOS) publications and several monographs, and currently includes information on 79 European species. The main advantage of our database is that it is open to downloading, uploading, and storing of data. This is extremely important, because a database's applicability increases with the quality of the data it contains. Initially in compiling the database, we encountered several fundamental shortcomings in the knowledge of some often easily measurable traits in, some species. We believe that in combination with new statistical methods dragonfly-database.eu will become a very useful tool for many ecological studies and more effective conservation of threatened species.
Interaction rituals and ‘police’ encounters: new challenges for interactionist police sociology

ABSTRACT Interactionist police sociology is in need of revision and extension in the face of profound change in policing, society, and in the very nature of ‘interaction’. The argument draws upon interaction ritual theory, a micro-sociological perspective that explores social life, and feelings of belonging and solidarity, as outcomes of encounters between people. Two tenets of the theory – that successful encounters produce emotional energy that creates bonds of solidarity, and that they require physical co-presence of human participants to work in this way – are being revised in the light of new empirical work exploring interaction with ‘others’ in a variety of new forms. The effect of this work is to provoke reassessment of what ‘counts’ as an encounter and to question the nature and sources of solidarity in an age when face-to-face physical co-presence is in decline. These features of interaction ritual theory are developed through three purposively-selected, illustrative applications of it to policing: police as reproducers of order; policing as information brokering; and, the changing landscape of security encounters. The article opens up new questions and objects of study for interactionist police research that are fit for the empirical realities of contemporary policing.
ECOLOGICAL LIFE ZONES OF BRAZIL

Many classification systems were developed to help in the mission of describing climate, but none of them is able to meet all areas of human activity. A system developed by Holdridge in 1947, called “life zones”, is considered the most ecological climate classification system because of the use of biotemperature. Several countries already have a life zones map and the purpose of this study is to classify each Brazilian municipalities according to this system. Temperature, precipitation, altitude and latitude data, provided by Alvares et al. (2013), were applied according to the methodology described by Holdridge (2000). The ecological life zones map was compared with the vegetation map through correlation matrices, which generated indices ranging from 0 to 100%. The results showed that Brazil has 35 life zones. The most common are tropical moist forest and tropical premontane moist forest, covering almost 50% of the country’s area. After the analysis of correlations, we could see that 21 LZs have more than 80% of their surfaces covered by two or less types of vegetation. The LZs distribution was consistent to the characteristics of each region, in terms of vegetation and climate; therefore, the Holdridge system can be considered a relevant and specific option for decision making related to agricultural and forestry activities.
Modeling Malicious Hacking Data Breach Risks

Malicious hacking data breaches cause millions of dollars in financial losses each year, and more companies are seeking cyber insurance coverage. The lack of suitable statistical approaches for scoring breach risks is an obstacle in the insurance industry. We propose a novel frequency–severity model to analyze hacking breach risks at the individual company level, which would be valuable for underwriting purposes. We find that breach frequency can be modeled by a hurdle Poisson model, which is different from the negative binomial model used in the literature. The breach severity shows a heavy tail that can be captured by a nonparametric- generalized Pareto distribution model. We further discover a positive nonlinear dependence between frequency and severity, which our model also accommodates. Both the in-sample and out-of-sample studies show that the proposed frequency–severity model that accommodates nonlinear dependence has satisfactory performance and is superior to the other models, including the independence frequency–severity and Tweedie models.
Calcium signaling is involved in diverse cellular processes in fungi

ABSTRACT Calcium (Ca2+) is a universal signalling molecule of life. The Ca2+ signalling is an evolutionarily conserved process from prokaryotes to eukaryotes. Ca2+ at high concentration is deleterious to the cell; therefore, cell maintains a low resting level of intracellular free Ca2+ concentration ([Ca2+]c). The resting [Ca2+]c is tightly regulated, and a transient increase of the [Ca2+]c initiates a signalling cascade in the cell. Ca2+ signalling plays an essential role in various processes, including growth, development, reproduction, tolerance to stress conditions, and virulence in fungi. In this review, we describe the evolutionary aspects of Ca2+ signalling and cell functions of major Ca2+ signalling proteins in different fungi.
Design of Low-Cost Synchronous Machine to Prevent Demagnetization

The request for high efficiency motor paves the way for the replacement of induction motors with permanent magnet synchronous motors. Although the efficiency is increased, for medium and high power, the current ripple causes significant additional losses in the magnet and lamination; and, high temperature can lead to demagnetization. In this paper, a new rotor topology is proposed and compared to a traditional surface permanent magnet rotor to reduce the magnet losses and protect them from demagnetization. A reference surface permanent magnet machine is compared with the proposed one in terms of performance and magnet losses. Both analytical and experimental analysis are carried out and discussed.
Probiotics and their significance in therapeutic nutrition

Probiotics are living beings that happen normally in the digestive tract. Numerous corresponding and matured nourishments additionally contain probiotics. A few people wonder if probiotics can assist them with getting more fit. Taking probiotic enhancements can help keep the verdure of the digestive tract adjusted and advance a sound body by boosting the assimilation and invulnerable framework. Scientists imagine that a portion of these microscopic organisms may assume a job in weight reduction and recapture. In the digestive system, valuable microscopic organisms help to separate and process nourishment. Probiotics have appeared to influence the structure of the gut microbiota, improve gut respectability, and reestablish corpulence's microbial movements. Keywords: Probiotics bacteria Lactobacillus and Bifidobacterium
Research on the Application of Computer Recording Technology in Modern Chinese Bopomofo

With the development of science and technology, the computer has gradually replaced the pen and paper, and even is more important in many occasions. Also, people’s dependence on the computer is deepening. While the importance of Bopomofo is in decline, Bopomofo teaching has been in a dangerous position. But actually, Bopomofo is the foundation of learning Chinese, the importance of language learning is self-evident. This paper mainly discusses the application of modern Chinese Bopomofo in computer recording technology.