Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of CYP2C19 polymorphisms on antiplatelet efficacy of clopidogrel in patients after myocardial infarction

Aim. The aim of this study was to evaluate the complex effects of polymorphisms of the gene encodingthe CYP2C19 enzyme on the antiplatelet efficacy of clopidogrel during follow-up visits. Material and methods. This study was designed as a prospective, single-centre observational clinical trialwith a one-year follow-up. Data from 178 patients on clopidogrel, taken during follow-up visits, was analysed. Results. Patients were divided into three groups according to the expected metabolic activity of theCYP2C19enzyme: ‘superior metabolisers’ (681 GG + 806 CT or TT), ‘neutral metabolisers’(681 GG + 806 CC and 681 GA or AA + 806 CT or TT) and ‘inferior metabolisers’ (681 GA or AA + 806 CC). The antiplatelet effect of clopidogrel was strongest in ‘superior metabolisers’ and weakest in ‘inferior metabolisers’,as assessed by adenosine diphosphate (ADP)-induced platelet aggregation and the VASP assay.Comparison of results of ADP-induced platelet aggregation measurements in pairs showed a significantdifference (p = 0.03) only between ‘superior metabolisers’ vs. ‘inferior metabolisers’. With the VASP assay,significant differences between ‘superior metabolisers’ and ‘neutral metabolisers’ (p = 0.013), ‘neutralmetabolisers’ and ‘inferior metabolisers’ (p = 0.015), and ‘superior metabolisers’ and ‘inferior metabolisers’(p = 0.00003) were found. No impact on clinical outcome was present. A tendency for an increasingneed for a clopidogrel-to-prasugrel switch was observed with a decrease in CYP2C19 metabolic activity. Conclusion. Multiple polymorphisms of the gene encoding the CYP2C19 enzyme have a significant impacton the antiplatelet efficacy of clopidogrel during follow-up visits; however, their influence on clinicaloutcome needs further clarification.
AAU-BOT1: a platform for studying dynamic, life-like walking

This paper describes the development of the humanoid robot AAU-BOT1. The purpose of the robot is to investigate human-like walking and in this connection, test prosthetic limbs. AAU-BOT1 has been designed with modularity in mind making it possible to replace, e.g. the lower leg to test transfemoral or transtibial prosthesis or orthosis. Recorded motion data from a male test person, along with approximated inertial and mass properties, were used to determine necessary joint torques in human walking which was used as design parameters for the robot. The robot has 19 degrees of freedom DoF, 17 actuated and 2 unactuated acting as passive toe joints. The project was granted 60,000 Euro, and to keep development costs below this, the development and instrumentation was carried out by three groups of master students from the Department of Mechanical Engineering ME and the Department of Electronic Systems at Aalborg University and supported by the Department of Health Sciences and Technology HST. To further reduce the cost, the robot uses off-the-shelf hardware which also reduced the time from idea to practical implementation. The result is a low-cost humanoid robot fully assembled and equipped with sensors ready to take its first steps.
Chapter 5 Lipoprotein-Associated Phospholipase A 2 – Pathophysiological Role and Clinical Significance as a Cardiovascular Biomarker

Within the last decade, a broad range of biomarkers associated with an increased risk for death and cardiovascular/cerebrovascular endpoints have been identified. Epide‐ miological studies clearly indicate that lipoprotein-associated phospholipase A2 (LpPLA2) has the potential to become clinically useful emerging biomarker in the true sense, linking plaque biology with cardiovascular/cerebrovascular event rate. Lipo‐ protein-associated phospholipase A2 is a specific vascular inflammatory marker, a risk factor, a prognostic biomarker, and also a therapeutic target. This chapter will sum‐ marize our current knowledge on Lp-PLA2 with emphasis on its potential pathophy‐ siological mechanisms of action and on clinical relevance as cardiovascular/ cerebrovascular biomarker. This chapter gives comprehensive, systematic review of studies assessing the significance of Lp-PLA2 in cardiovascular/cerebrovascular dis‐ eases with emphasis on clinical benefit of pharmacologic inhibition of Lp-PLA2.
North Atlantic in fl uence on 19 th e 20 th century rainfall in the Dead Sea watershed , teleconnections with the Sahel , and implication for Holocene climate fl uctuations

The importance of understanding processes that govern the hydroclimate of the Mediterranean Basin is highlighted by the projected significant drying of the region in response to the increase in greenhouse gas concentrations. Here we study the long-term hydroclimatic variability of the central Levant region, situated in the eastern boundary of the Basin, as reveled by instrumental observations and the Holocene record of Dead Sea level variations. Observations of 19th and 20th century precipitation in the Dead Sea watershed region display a multidecadal, anti-phase relationship to North Atlantic (NAtl) sea surface temperature (SST) variability, such that when the NAtl is relatively cold, Jerusalem experiences higher than normal precipitation and vice versa. This association is underlined by a negative correlation to precipitation in the sub-Saharan Sahel and a positive correlation to precipitation in western North America, areas that are also affected by multidecadal NAtl SST variability. These observations are consistent with a broad range of Holocene hydroclimatic fluctuations from the epochal, to the millennial and centennial time scales, as displayed by the Dead Sea lake level, by lake levels in the Sahel, and by direct and indirect proxy indicators of NAtl SSTs. On the epochal time scale, the gradual cooling of NAtl SSTs throughout the Holocene in response to precession-driven reduction of summer insolation is associated with previously well-studied wet-to-dry transition in the Sahel and with a general increase in Dead Sea lake levels from low stands after the Younger Dryas to higher stands in the midto late-Holocene. On the millennial and centennial time scales there is also evidence for an antiphase relationship between Holocene variations in the Dead Sea and Sahelian lake levels and with proxy indicators of NAtl SSTs. However the records are punctuated by abrupt lake-level drops, which appear to be in-phase and which occur during previously documented abrupt major cooling events in the Northern
NASOPALATINE DUCT CYST CONCURRENT WITH SUPERNUMERARY TOOTH: A CASE REPORT

Nasopalatine duct cyst is a cyst located in the anterior maxilla and constitutes 1% of the cysts located in that region. Presence of a cyst concurrent with a supernumerary tooth at that region is rarely seen. The best we know, there is only one report in literature which nasopalatinal duct cyst concurrent with a mesiodens in a case. This case report presents an expanded nasopalatine duct cyst that includes a supernumerary tooth within its boundaries.
Estimating the Worth of Traits of Indigenous Breeds of Cattle in Ethiopia

Livestock in general and cattle in particular are indispensable components of rural livelihoods in Ethiopia. In semi-arid and arid parts of the country, the pastoral communities depend mainly on their livestock for their livelihoods (Little et al. 2001; Barrett et al. 2003; Ouma et al. 2007). In the more dominant mixed crop-livestock livelihood system, cattle serve in providing traction power, in generating cash, in buffering shocks, as sources of consumables, as sources of prestige, and as the main indicator of wealth. The vital importance of cattle in supporting rural livelihoods against the backdrop of negative effects of climate change and continuing erosion of animal genetic resources (AnGR) justify a thorough analysis of the preferred characteristics of cattle to guide conservation and improvement programs.
Quantum theory of continuum optomechanics

We present the basic ingredients of continuum optomechanics, i.e. the suitable extension of cavity-optomechanical concepts to the interaction of photons and phonons in an extended waveguide. We introduce a real-space picture and argue which coupling terms may arise in leading order in the spatial derivatives. This picture allows us to discuss quantum noise, dissipation, and the correct boundary conditions at the waveguide entrance. The connections both to optomechanical arrays as well as to the theory of Brillouin scattering in waveguides are highlighted. Among other examples, we analyze the ‘strong coupling regime’ of continuum optomechanics that may be accessible in future experiments.
MULTIPLE INTENTIONS

Recent advances in learning from demonstrations (LfD) with deep neural networks have enabled learning complex robot skills that involve high dimensional perception such as raw image inputs. LfD algorithms generally assume learning from single task demonstrations. In practice, however, it is more efficient for a teacher to demonstrate a multitude of tasks without careful task set up, labeling, and engineering. Unfortunately in such cases, traditional imitation learning techniques fail to represent the multi-modal nature of the data, and often result in sub-optimal behavior. In this paper we present an LfD approach for learning multiple modes of behavior from visual data. Our approach is based on a stochastic deep neural network (SNN), which represents the underlying intention in the demonstration as a stochastic activation in the network. We present an efficient algorithm for training SNNs, and for learning with vision inputs, we also propose an architecture that associates the intention with a stochastic attention module. Furthermore, we demonstrate our method on real robot visual object reaching tasks, and show that it can reliably learn the multiple behavior modes in the demonstration data. Video results are available at https://vimeo.com/240212286/fd401241b9.
SCIENTISTS AS MIDWIVES TO CLUSTER EMERGENCE- AN INTERPRETATIVE CASE STUDY OF FUNCTIONAL FOODS

We investigate the emergence of a spatial concentration of interconnecte d individuals and organisations in a new field. In contrast to approaches where clusters are perceived as collections of atomistic firms, we stress the role of individual agency and institutional embeddedness in the emergence and sustainability of clusters. We argue that our current understanding of cluster emergence can be advanced by extending the coupling metaphor as a conceptual tool for investigating cluster dynamics both at micro and system level. We contend that scientists, enabled by their network positions, act as institutional entrepreneurs to create tight couplings at the cluster level. Such individual level activity crosses industry and spatial boundaries and increases the innovativeness of the cluster. Based on a longitudinal case study of a cholesterol-lowering functional foods cluster in Finland, we propose a novel analytical classification of different roles for scientists along cluster emergence.
QUANTIFYING INTROGRESSION AT THE GENE LEVEL IN STRONGYLOCENTROTID URCHINS

5 Introduction . 6 Methods . 10 Results . 18 Discussion . 26 Acknowledgements . 33 References. 34 Table of Figures and Tables Figure 1: Phylogenetic tree of Strongylocentrotid urchins showing the six-focal species as well as well as their general distribution, and their preferred depth: Deep, Moderate, or Shallow. The distribution of species is abbreviated as NWP and NEP for Western and Eastern Pacific, and CIR for Circumpolar, which means species are in the Artic as well as the NE and NW Pacific. A. is Allocentrotus H. is Hemicentrotus, and P is Pseudocentrotus. Note species names have not yet been changed to reflect phylogenetic findings. From Kober and Pogson 2017. 8 Figure 2: Flow chart showing the different stages of the introgression detection pipeline pioneered in this study. 10 Figure 3: Direction and magnitude of detected introgression events. Introgression events with more than eight genes have bolded counts for clarity. Arrows to scale by width. 18 Figure 4: Sp-Z59 has conflicting genetic histories in different exons that obscured introgression at the whole genes level and resulted in the recovering of a whole gene tree with a different topology. 22 Figure 5: Sp-CholdhL has conflicting genetic histories that result in reduced bootstrap support for the introgression topology in the whole gene tree. 23 Figure 6: Many Introgressed Sites are Non-Synonymous . 24 Figure 7: Verified Introgression events plotted by species pair . 25 -----------------------Table 1: The relative performance of each initial identification test and combination thereof from identification to quantification of introgression. Note: Not all VI genes had ABBA-BABA testable topologies. 18 Table 2: Ranked Wilcox Test Results of the K2PDs of VI genes against the full data set. Significant results bolded. 19 Quantifying Adaptive Introgression in Strongylocentrotid Urchins Kan 4 Table 3: Gene Ontology Term Enrichment and Under-Enrichment for Verified Introgression Genes. Membrane and receptor related categories in italics. P-values corrected for a FDR of 0.05. 21 Quantifying Adaptive Introgression in Strongylocentrotid Urchins Kan 5
Synthesis and Application of Surface-modified NiFe Nanoparticles as a new Magnetic Nano Adsorbent for the Removal of Nickel Ion from Aqueous Solution

Magnetic alloy Ni2.33Fe nanoparticles were prepared using hydrothermal method and used for removing nickel ion from aqueous solution. The magnetic particles were characterized by XRD, SEM, TG and FTIR, which confirms that the magnetic product is nano NiFe alloy with fcc-type structure and its surface were successfully modified by sodium citrate. The adsorption kinetics studies were performed and pseudo-second-order kinetic model successfully described the kinetic data. The Freundlich and Langmuir adsorption models were used for the mathematical description of adsorption equilibrium and it was found that the experimental data fitted very well to the Freundlich model.
Comparative Analysis of Alternative Credit Risk Models

In recent years new methods and models have been developed to quantify credit risk on a portfolio basis. CreditMetricsTM, CreditRisk, CreditPortfolioView are among the best known and many others are similar to them. At first glance they are quite different in their approaches and methodologies. A comparison of these models especially with regard to their applicability on typical middle market loan portfolios is in the focus of this study. The analysis shows that differences in the results of an application of the models on a certain loan portfolio is mainly due to different approaches in approximating default correlations. That is especially true for typically non-rated medium-sized counterparties. On the other hand distributional assumptions or different solution techniques in the models are more or less compatible. Zusammenfassung: Seit einigen Jahren finden sich in Wissenschaft und Bankpraxis neue Methoden und Modelle, um Risiken von Kreditportfolios zu messen. Zu den bekanntesten Vertretern gehören CreditMetrics, CreditRisk und CreditPortfolioView, welche sich auf den ersten Blick stark im Ansatz und in der Methodik unterscheiden. Im Mittelpunkt der vorliegenden Studie steht ein Vergleich dieser Modelle und zwar insbesondere hinsichtlich ihrer Anwendbarkeit auf ein typisches Portfolio aus mittelständischen Bankkrediten. Die Analyse zeigt, dass Unterschiede in den Ergebnissen zweier Modelle für ein und dasselbe Portfolio vor allem auf unterschiedliche Verfahren in der Approximation von Ausfallkorrelationen zurückzuführen sind. Dies gilt insbesondere für Kredite an nicht-geratete mittelständische Unternehmen.
FENTON AND SOLAR PHOTO-FENTON OXIDATION OF INDUSTRIAL WASTEWATER CONTAINING PESTICIDES

Assessment the efficiency of Fenton process (Fe 2+ /H2O2), versus photo-Fenton reaction (TiO2/Fe 2+ /H2O2/UV) for removal of Chloropyrifos, and COD from pesticide wastewater were investigated. Solar compound parabolic collectors (CPC) pilot scale with borosilicate tubes was used for photo-Fenton process. The effect of reaction time, initial pH and dosage of H2O2, FeSO4, TiO2 were studied for both processes. The results obtained indicated that the optimum pH and reaction time were 3.6, and 120 min respectively. Both Fenton and photo-Fenton reaction were very effective for removal of COD and Chloropyrifos at dosage of 2 gm/L for TiO2, 4 gm/L for FeSO4.7H2O, and 1 gm/L for H2O2. However, photo catalytic oxidation process improved the removal efficiency of Chloropyrifos by a value of 27 % as compared to Fenton process. The effluent quality of COD resulting from Fenton reaction was 3070 mg/L and significantly decreased up to 2190 mg/L after the post-precipitation using lime. Photo-Fenton reaction achieved an effluent quality of 2230 mg/l for COD of which greatly decreased up to 1650 mg/L with lime precipitation. Based on these results, it is recommended to apply photo-catalytic oxidation process for treatment of wastewater rich pesticide.
The WEBT campaign on the BL Lac object PG 1553+113 in 2013. An analysis of the enigmatic synchrotron emission

A multifrequency campaign on the BL Lac object PG 1553+113 was organized by the Whole Earth Blazar Telescope (WEBT) in 2013 April–August, involving 19 optical, two near-IR, and three radio telescopes. The aim was to study the source behaviour at low energies during and around the high-energy observations by the Major Atmospheric Gamma-ray Imaging Cherenkov telescopes in April–July. We also analyse the UV and X-ray data acquired by the Swift and XMM‐Newton satellites in the same period. The WEBT and satellite observations allow us to detail the synchrotron emission bump in the source spectral energy distribution (SED). In the optical, we found a general bluer-when-brighter trend. The X-ray spectrum remained stable during 2013, but a comparison with previous observations suggests that it becomesharderwhentheX-rayfluxincreases.ThelongXMM‐Newtonexposurerevealsacurved X-ray spectrum. In the SED, the XMM‐Newton data show a hard near-UV spectrum, while SwiftdatadisplayasoftershapethatisconfirmedbypreviousHubbleSpaceTelescope/Cosmic Origins Spectrograph and International Ultraviolet Explorer observations. Polynomial fits to the optical–X-ray SED show that the synchrotron peak likely lies in the 4–30 eV energy range, with a general shift towards higher frequencies for increasing X-ray brightness. However, the UV and X-ray spectra do not connect smoothly. Possible interpretations include: (i) orientation effects, (ii) additional absorption, (iii) multiple emission components, and (iv) a peculiar energy distribution of relativistic electrons. We discuss the first possibility in terms of an inhomogeneous helical jet model.
Are Veterans Subjected to Social Indifference

Introduction: Social Indifference is a difficult thing to prove. There have been many studies on the subject and often the conclusions lead us to believe that social indifference was a primary factor. Yet indifference can be one of many underlying contributing causes that may lead to the end results, and therefore it would be a fallacy to argue its existence based on the actions of a large cohort simply because such generalized assumptions could have any number of different causes contributing to an end result. Nevertheless, indifference is a very real problem.
Psychological Processes in Cooperative Language Learning: Group Dynamics and Motivation.

Cooperative learning (CL) has been found to be a highly effective instructional approach in education in general and this has been confirmed with regard to second language (L2) learning as well. This article investigates reasons for the success of CL from a psychological perspective, focusing on two interrelated processes: the unique group dynamics of CL classes and the motivational system generated by peer cooperation. It is argued that the affective domain of CL plays a crucial role in the educational potential of the method. This paper summarizes the specific factors that contribute to the promotion of learning gains. While the analysis concerns cooperatively structured learning only, it is assumed that the processes described have a broader relevance to understanding the success of peer collaboration in general.
Comparing Deep Learning and Classical Machine Learning Approaches for Predicting Inpatient Violence Incidents from Clinical Text

Machine learning techniques are increasingly being applied to clinical text that is already captured in the Electronic Health Record for the sake of delivering quality care. Applications for example include predicting patient outcomes, assessing risks, or performing diagnosis. In the past, good results have been obtained using classical techniques, such as bag-of-words features, in combination with statistical models. Recently however Deep Learning techniques, such asWord Embeddings and Recurrent Neural Networks, have shown to possibly have even greater potential. In this work, we apply several Deep Learning and classical machine learning techniques to the task of predicting violence incidents during psychiatric admission using clinical text that is already registered at the start of admission. For this purpose, we use a novel and previously unexplored dataset from the Psychiatry Department of the University Medical Center Utrecht in The Netherlands. Results show that predicting violence incidents with state-of-the-art performance is possible, and that using Deep Learning techniques provides a relatively small but consistent improvement in performance. We finally discuss the potential implication of our findings for the psychiatric practice.
Design of an integrated antenna for automotive systems

This paper describes the design process of an integrated antenna for an automotive rescue system. In order to fulfill the antenna‐design requirements in different frequency bands and minimize the interference phenomena arising from the integration of different classes of antennas in a single device, a two‐phases stochastic‐optimization approach is used. The experimental validation carried out on the developed prototype confirms the effectiveness of the proposed approach. © 2005 Wiley Periodicals, Inc. Microwave Opt Technol Lett 47: 513–515, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.21214