Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluación de la calidad de una sesión de registro simultáneo de la fuerza oclusal y la actividad electromiográfica del músculo masetero

The aim of the present investigation was to evaluate the quality of a session of simultaneous registration of bite force and AEMG in a group of 19 young adults, during four functional tasks: maximal opening, maximal cuspation, bite on the gnatodinamometer on the right side and bite on the gnatodinamometer on the left side. Three registrations were obtained for each task in one day. A grouped descriptive, a global and an individual analysis of the data was performed. It was found a high correlation when evaluating the symmetry of the AEMG registration in maximal opening (r = 0.83) and bite force (r = 0.92) and it was not found a good correlation in the EMG registration neither in maximal cuspation (r = 0.46) nor in the right and left masseter muscle during the unilateral bite on each side, when analyzing the EMG of the work and balance side.
Natural Cytotoxicity of Human Fcγ‐Receptor‐positive T Lymphocytes after Surface Modulation with Immune Complexes

In humans T cells with surface receptors for the Fc fragment of IgG (Fcγ receptors) (TG cells) are effector cells in antibody‐dependent cellular Cytotoxicity (ADCC) and in natural cytotoxicity. While Fcγ receptors are required to mediate ADCC, their role in natural cytotoxicity is unknown. To investigate this question, Fcγ receptors on effector cells were modulated by interaction with IgG immune complexes. As a consequence of this modulation, TG cells lost most of their ADCC activity but retained a significant part of their natural killer activity. Thus, these experiments demonstrate that the cytotoxic mechanisms exerted by the same cell population can be dissociated experimentally. Furthermore, they suggest that the net natural cytotoxicity of normal human lymphocytes in certain effector cell‐target cell combinations is the result of distinct types of reaction.
New biopolyimdies possibly applicable to heat-resistant and transparent insulator

Bioplastics are indispensable for establishing low-carbonization society in terms of long-term carbon stock in the bio-based materials. This paper reviews the recent trends and developments of high-performance biopolyimides from 4-aminocinamic acid. They had higher thermoresistance than conventional bio-based plastics and transparent plastic films owing to rigid ring structures.
New acoustic method for detecting upper airway obstruction in patients with sleep apnoea

Background and objective: OSA is a common disorder resulting in health and economic burdens. Currently identifying OSA in patients involves expensive techniques that require overnight studies in a laboratory setting with qualified staff. This paper tests a new acoustic device (AirwayClear (AC)) for assessing upper airway patency in human subjects with OSA. We hypothesize that obstructive apnoeas would be detected equally well with AC and polysomnography (PSG).
Neurosteroid Hydroxylase CYP7B

The major adrenal steroid dehydroepiandrosterone (DHEA) enhances memory and immune function but has no known dedicated receptor; local metabolism may govern its activity. We described a cytochrome P450 expressed in brain and other tissues, CYP7B, that catalyzes the 7α-hydroxylation of oxysterols and 3β-hydroxysteroids including DHEA. We report here that CYP7B mRNA and 7α-hydroxylation activity are widespread in rat tissues. However, steroids related to DHEA are reported to be modified at positions other than 7α, exemplified by prominent 6α-hydroxylation of 5α-androstane-3β,17β-diol (A/anediol) in some rodent tissues including brain. To determine whether CYP7B is responsible for these and other activities we disrupted the mouse Cyp7b gene by targeted insertion of an IRES-lacZ reporter cassette, placing reporter enzyme activity (β-galactosidase) underCyp7b promoter control. In heterozygous mouse brain, chromogenic detection of reporter activity was strikingly restricted to the dentate gyrus. Staining did not exactly reproduce the in situ hybridization expression pattern; post-transcriptional control is inferred. Lower level staining was detected in cerebellum, liver, and kidney, and which largely paralleled mRNA distribution. Liver and kidney expression was sexually dimorphic. Mice homozygous for the insertion are viable and superficially normal, but ex vivo metabolism of DHEA to 7α-hydroxy-DHEA was abolished in brain, spleen, thymus, heart, lung, prostate, uterus, and mammary gland; lower abundance metabolites were also eliminated. 7α-Hydroxylation of 25-hydroxycholesterol and related substrates was also abolished, as was presumed 6α-hydroxylation of A/anediol. These different enzyme activities therefore derive from the Cyp7bgene. CYP7B is thus a major extrahepatic steroid and oxysterol hydroxylase and provides the predominant route for local metabolism of DHEA and related molecules in brain and other tissues.
Radio Mesh Networks and the Round Weighting Problem. (Les Réseaux Radio Maillés et le Problème du "Round Weighting")

Dans cette these, nous etudions le probleme joint du routage et de l'attribution des "slots" entre les routeurs et les points d'acces dans les reseaux radio mailles. Nous le modelisons comme un probleme de "Round weighting" dont l'objectif est de minimiser la periode d'activation des "slots" en assurant une capacite suffisante pour repondre aux demandes de bande passante des routeurs. Resoudre le probleme dans son integralite necessite la generation d'un ensemble exponentiel de "rounds", ce qui est hors de portee meme pour des petits reseaux. Par consequent, nous developpons un modele mathematique multicritere qui resout le probleme en utilisant une methode de generation de colonnes. Nous observons que le goulot d'etranglement est en general situe autour d'un point d'acces. Nous proposons une methode pour obtenir des bornes inferieures et des bornes superieures pour les graphes generaux. Nous appliquons ces methodes aux grilles obtenant des formules closes pour des demandes uniformes et des strategies optimales de routage pour des demandes non-uniformes. Motive par les resultats sur l'existence d'une region limitee capable de representer le reseau dans sa totalite, on considere une variante du RWP qui traite aussi de l'allocation de bande mais en considerant le SINR dans un reseau CDMA. Nous donnons des conditions suffisantes pour qu'un reseau puisse etre reduit a un reseau mono-saut autour du point d'acces. Cela est du au fait que le probleme est convexe. Nous nous interessons aux solutions Pareto-optimales pour lesquelles chaque flot dans le goulot recoit une partie juste de la bande passante disponible.
Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease

Epidemiological and experimental studies have shown that exposure to the gastric bacterium Helicobacter pylori, especially in early life, prevents the development of asthma. Recent mouse studies have shown that this protective effect does not require live bacteria and that treatment with an extract of H. pylori in neonates prevents the development of airway inflammation and goblet cell metaplasia. In the current study, the effect of administration of an extract of H. pylori was assessed in a therapeutic study design with application of the extract just prior to allergen challenge. C57BL/6 mice were sensitized and challenged with OVA or house dust mite. Treatment with H. pylori extract just prior to the challenge significantly reduced airway inflammation, as assessed in bronchoalveolar lavage fluid and lung tissue, and reduced airway remodeling, as assessed by goblet cell quantification. These effects were apparent in the OVA model and in the house dust mite model. Injection of H. pylori extract reduced the processing of allergen by dendritic cells in the lungs and mediastinal lymph node. Bone marrow–derived dendritic cells exposed to H. pylori extract were affected with regard to their ability to process Ag. These data show that application of H. pylori extract after sensitization effectively inhibits allergic airway disease.
Specification and Standardization of a Java Trusted Computing API

The paradigm of Trusted Computing promises a new approach to improve the security of computer systems. The core functionality, based on a hardware component known as Trusted Platform Module, is integrated into commodity hardware. However, operating system integration and application software support remains limited at present. In particular, for Java, the most widely used platform‐independent computing environment, there is currently no generally accepted Trusted Computing API. In this article, we describe the design of a high‐level API for Trusted Computing. We report on the current state of the Trusted Computing Group's software architecture and on previous approaches targeting Java. We derive our requirements and design goals and describe a novel API design. We report on our transparent approach to standardization in the Java Community Process. The result of this effort is the API we propose in the Java Specification Request 321. In this work, we not only present the design of this new API but also discuss implementation and testing strategies. Copyright © 2011 John Wiley & Sons, Ltd.
The augmented painting: Playful interaction with multi-spectral images

Museum conservators and researchers often take multi-spectral captures of the paintings they study, commonly using x-ray, infrared and ultraviolet equipment. Usually these captures are not accessible to the museum visitor, even though they offer valuable information about the painting. Since 2009 the AR Lab has been developing installations which allow museum visitors to explore these special captures in an user-friendly and playful way. This article describes and comments on the different phases this project went through, and gives a preview of our latest augmented reality application.
Hardness-by-design approach for 0.15 /spl mu/m fully depleted CMOS/SOI digital logic devices with enhanced SEU/SET immunity

We designed logic cells hardened for single-event upsets/single-event transients (SEUs/SETs) using hardness-by-design (HBD) methodology on OKI's 0.15 /spl mu/m fully depleted complementary metal-oxide-semiconductor/silicon-on-insulator (CMOS/SOI) commercial process and evaluated the sample devices. Our previous work demonstrates that SET-free inverters can be successfully applied as SEU-immune latches. In this paper, the native latches are redesigned using SET-free inverters not only for the inverter loop but also for several types of clock gates (L-SETfree-LoopCK, L-SETfree-LoopCK-SmallArea, and L-SETfree-LoopCK-AddTr.). In addition, the native combinational logic cells are redesigned using SET-free inverters as SET-free NAND and SET-free NOR . Excellent SEU/SET hardness of the HBD latches were achieved up to LET of 64 MeV/(mg/cm/sup 2/).
Transplantable Marek's disease lymphomas. IV. Differences in lethality of lymphoma cell lines determined by route of inoculation.

Mortality caused by inoculation of cells from four Marek's disease herpes virus-induced transplantable lymphomas was studied in two related inbred lines of chickens. While i.m. inoculation of 10(4) cells from each lymphoma generally caused death of all syngeneic recipients by 18 days post-inoculation, one of the lymphomas (UG2) was unique in that the same number of cells, when inoculated i.v. , caused less than 20% mortality by that time. Lethality induced by cells from the other three lymphomas, when inoculated i.v. , was as high or higher than when inoculated i.m. Mortality after intra-abdominal or s.c. inoculation of cells from all four lymphomas was similar to that after i.m. inoculations. Chickens inoculated with syngeneic UG2 cells by the i.v. route were significantly protected against a subsequent i.m. challenge with the same or other syngeneic lymphoma cells. However, UG2 lymphoma cells were highly lethal when inoculated i.v. into birds previously treated with the antimacrophage agent carageenan or immunosuppressed by neonatal treatment with cyclophosphamide. Thus, UG2 cells are distinctive in that, when inoculated i.v. , they do not cause death of syngeneic hosts but instead induce resistance to a lethal challenge.
Characterization of phi 13, a bacteriophage related to phi 6 and containing three dsRNA genomic segments.

The three dsRNA genomic segments of bacteriophage Phi 13 were copied as cDNA and the nucleotide sequences were determined. The organization of the genome is similar to that of Phi 6, and there is significant similarity in the amino acid sequences of the proteins of the polymerase complex and one of the membrane proteins, P6. There is little or no similarity in the nucleotide sequences. Several features of the viral proteins differ markedly from those of Phi 6. Although both phages are covered by a lipid-containing membrane, the protein compositions are different. The host attachment protein consists of two peptides rather than one and the phage attaches directly to the LPS of the host rather than to a Type IV pilus. Despite the differences in the structure of the membranes, the two viruses can successfully exchange the genes for host attachment proteins and thereby change their host specificities.
Notice of RetractionResearch the Performance of Polycyclic Aromatic Hydrocarbons (PAHs) Removal by NF Membranes

PAHs, which have a disrupting effects on human's health, is increasingly noticed in aquatic environment. And it is essential to find an efficiency way to remove PAHs from water. By contrast, nanofiltration technology is a better way than traditional methods. This paper offers a study on the impact of ionic strength, pH and adsorption on the PAHs (naphthalene, phenanthrene and fluoranthene) removal by nanofiltration membrane. The experimental results indicated that there is a higher flux by BDXN-70 NF membrane than by BDXN-90 NF membrane and the rejection of PAHs relatively efficiency for BDXN-70 membrane. The trace PAHs in water could be better rejected (rejections are more than 95%) by nanoflltration membrane stability at acidic solutions. There is little influence of rejection on the different ionic strength except naphthalene. Moreover, there is a large adsorption in the beginning and it declines significantly at the later time. After 6 h, it is seemed to have reached saturation. Then the rejection will maintain constant until the membrane were fouled seriously.
Exploring the Impact of a Low-Protein High-Carbohydrate Diet in Mature Broodstock of a Glucose-Intolerant Teleost, the Rainbow Trout

Sustainable aquaculture production requires a greater reduction in the use of marine-derived ingredients, and one of the most promising solutions today is the augmentation in the proportion of digestible carbohydrates in aquafeed. This challenge is particularly difficult for high trophic level teleost fish as they are considered to be glucose-intolerant (growth delay and persistent postprandial hyperglycemia observed in juveniles fed a diet containing more than 20% of carbohydrates). It was previously suggested that broodstock could potentially use carbohydrates more efficiently than juveniles, probably due to important metabolic changes that occur during gametogenesis. To investigate this hypothesis, 2-year old male and female rainbow trout (Oncorhynchus mykiss) were either fed a diet containing no carbohydrates (NC) or a 35%-carbohydrate diet (HC) for an entire reproductive cycle. Zootechnical parameters as well as the activities of enzymes involved in carbohydrate metabolism were measured in livers and gonads. Fish were then reproduced to investigate the effects of such a diet on reproductive performance. Broodstock consumed the HC diet, and in contrast to what is commonly observed in juveniles, they were able to grow normally and they did not display postprandial hyperglycemia. The modulation of their hepatic metabolism, with an augmentation of the glycogenesis, the pentose phosphate pathway and a possible better regulation of gluconeogenesis, may explain their improved ability to use dietary carbohydrates. Although the HC diet did induce precocious maturation, the reproductive performance of fish was not affected, confirming that broodstock are able to reproduce when fed a low-protein high-carbohydrate diet. In conclusion, this exploratory work has shown that broodstock are able to use a diet containing digestible carbohydrates as high as 35% and can then grow and reproduce normally over an entire reproductive cycle for females and at least at the beginning of the cycle for males. These results are highly promising and suggest that dietary carbohydrates can at least partially replace proteins in broodstock aquafeed.
Do Psychosexual Factors Play a Role in the Etiology of Provoked Vestibulodynia? A Critical Review

The aim of this review was to critically examine published studies concerning the psychosexual aspects of provoked vestibulodynia. Despite the presence of several methodological limitations, some findings were consistently replicated. Overall, women with vestibulodynia demonstrate impaired sexual functioning, namely, lower levels of sexual desire, arousal, and frequency of intercourse. Childhood physical and sexual abuse represent potential risk factors for the development of this condition. Additionally, specific psychological states such as anxiety, fear of pain, hypervigilance, catastrophizing, and depression, are more frequently reported by these women. More rigorous studies are needed to establish which psychosexual variables may exacerbate and/or maintain vestibulodynia.
Exploring the potential of lecithin/chitosan nanoparticles in enhancement of antihypertensive efficacy of hydrochlorothiazide

The present study involves the preparation of lecithin/chitosan nanoparticles loaded with hydrochlorothiazide (HCT) (a poorly water soluble antihypertensive) and hydrochlorothiazide complexed with β-cyclodextrin (HCT-β-CD) with a view to improve its biopharmaceutical properties. Nanoparticles prepared using modified solvent evaporation method showed a particle size in the range of 126–139 and 152–181 nm (polydispersity index, PDI = 0.2) for HCT and HCT-β-CD loaded nanoparticles respectively. TEM images revealed their spherical nature. The stable nature of the prepared formulations was evident from the high positive value of zeta potential (>20 mV). HCT and HCT-β-CD loaded nanoparticles with 150 mg of drug have shown a maximum entrapment efficiency of 81.8 ± 1.7% and 91.1 ± 1.5% respectively. In vitro studies have shown an improved and a sustained release pattern. In vivo activity in DOCA induced hypertensive rats demonstrates 1.5-fold percentage decrease in systolic blood pressure and a prolonged duration of action.
A Survey : Handover scheme of High-Speed Train Environment

---------------------------------------------------------------------***--------------------------------------------------------------------Abstract In mobile communication, a handover is a process in which cellular data session is transferred from one cell site (base station) to another without disconnecting the session. Cellular services are based on mobility and handover, allowing the user to be moved from one cell site range to another or to be switched to the nearest cell site for better performance. Network mobility has a very challenging issue of long handover latency and QoS as the mobile devices moving with vehicular speed. In high speed train existing number of MT required the high quality communication and internet access services. As train speeds increases, wireless communication between MT in the train and the device mounted on the train encounters difficulties. In such case maintaining communication quality is a major challenge. The proposed system can resolve this issue by using an LTE femtocell based network mobility scheme that uses multiple egress network interface to support seamless handover for high speed train and avoid packet loss in network during handover.
Evaluation of an Immunochromatographic Lateral Flow Assay (OXA-48 K-SeT) for Rapid Detection of OXA-48-Like Carbapenemases in Enterobacteriaceae

ABSTRACT We evaluated an immunochromatographic lateral flow assay to detect OXA-48-like carbapenemases (OXA-48 K-SeT) in Enterobacteriaceae (n = 82). One hundred percent sensitivity and specificity were observed using bacteria recovered from both solid medium and spiked blood culture bottles, and the results were obtained in <10 min.
Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study.

RATIONALE The rapid diagnosis of pulmonary tuberculosis (TB) is difficult when acid fast bacilli (AFB) cannot be detected in sputum smears. OBJECTIVES Following a proof of principle study, we examined in routine clinical practice whether individuals with sputum AFB smear-negative TB can be discriminated from those with latent TB infection by local immunodiagnosis with a Mycobacterium tuberculosis-specific enzyme-linked immunospot (ELISpot) assay. METHODS Subjects suspected of having active TB who were unable to produce sputum or with AFB-negative sputum smears were prospectively enrolled at Tuberculosis Network European Trialsgroup centers in Europe. ELISpot with early-secretory-antigenic-target-6 and culture-filtrate-protein-10 peptides was performed on peripheral blood mononuclear cells (PBMCs) and bronchoalveolar lavage mononuclear cells (BALMCs). M. tuberculosis-specific nucleic acid amplification (NAAT) was performed on bronchoalveolar lavage fluid. MEASUREMENTS AND MAIN RESULTS Seventy-one of 347 (20.4%) patients had active TB. Out of 276 patients who had an alternative diagnosis, 127 (46.0%) were considered to be latently infected with M. tuberculosis by a positive PBMC ELISpot result. The sensitivity and specificity of BALMC ELISpot for the diagnosis of active pulmonary TB were 91 and 80%, respectively. The BALMC ELISpot (diagnostic odds ratio [OR], 40.4) was superior to PBMC ELISpot (OR, 10.0), tuberculin skin test (OR, 7.8), and M. tuberculosis specific NAAT (OR, 12.4) to diagnose sputum AFB smear-negative TB. In contrast to PBMC ELISpot and tuberculin skin test, the BALMC ELISpot was not influenced by previous history of TB. CONCLUSIONS Bronchoalveolar lavage ELISpot is an important advancement to rapidly distinguish sputum AFB smear-negative TB from latent TB infection in routine clinical practice.
Mitochondrial cytochrome c liberates the nucleophosmin-sequestered ARF tumor suppressor in the nucleolus

The alternative reading frame (ARF) protein is crucial in the cellular response to oncogenic stress, being likewise the second most frequently inactivated gene in a wide spectrum of human cancers. ARF is usually sequestered in the nucleolus by the well-known oncogenic nucleophosmin (NPM) protein and is liberated in response to cell damage to exhibit its tumor-suppressor ability. However, the mechanism underlying ARF activation is unknown. Here we show that mitochondria-to-nucleus translocation of cytochrome c upon DNA damage leads to the break-off of the NPM-ARF ensemble and subsequent release of ARF from the nucleoli. Our structural and subcellular data support a molecular model in which the hemeprotein triggers the extended-to-compact conformation of NPM and competes with ARF for binding to NPM.