AB0856 The impact of systemic inflammation and radiological changes on mobility in anchylosing spondylities

Objectives The purpose of the study was to investigate the relationship between disease activity, structural lesions and physical function by testing the hypothesis that the level of structural lesions contributes independently to physical impairment. Methods For this analysis, the database of Rheumatology Department was used and included 78 consecutive SA patients who have been observed for many years, implying that they have used NSAID’s and DMARD for progression disease, no one has used TNF blocking agents. Results BASFI and DFI correlated significantly (r 0.88). The correlation coefficient for mSASSS and BASFI was 0.508 and for mSASSS and DFI equal to 0.464, suggesting a moderate correlation relationship. The correlation coefficient for the relationship between BASDAI and BASFI was equal to 0.79 and for BASDAI and DFI equal to 0.69 suggesting a moderate to significant correlation. The correlation between mSASSS and BASFI or DFI was dependent on the BASDAI level. To further investigate the relationship between mSASSS and BASFI/DFI, concurrently adjusting for BASDAI and other covariates, a multivariate analysis was performed using GEE with BASFI or DFI as dependent variables, and mSASSS and BASDAI as covariates, concurrently adjusting for age, sex, duration of illness, HLA-B27 status and hip involvement. Both BASDAI and mSASSS contributed independently to the BASFI and DFI explanations with significant parameter estimates. Regression coefficients describe the independent relationship between the explanatory variables and the dependent variable: in the environment, compared to a patient with mSASSS 40, a patient with the mSASSS score 50 has a BASFI of 0.57 times greater, independent of BASDAI. All mSASSS subscripts contributed independently to the explanation of BASFI variations (p<0.001). Compared to the mSASSS model, which had the best result, the model with the total score of the syndesmofite, the number of the affected vertebral units, the number of vertebral vertebral units, and the model with the non-syndesmophitary summary score, it was deduced that the syndesmophites are in much but not exclusively responsible for explaining variations in BASFI. A model with the sindesmophites summary score (p<0.001) and the non-syndesmophyte (p=0.002) shows that both components contribute significantly to the explanation of BASFI variations. Results with DFI were similar. Using mSASSS, the syndesmophyte subservices, the affected vertebral units or vertebral vertebral units, we showed that lumbar and cervical spine involvement contributed independently and almost similarly to explaining variations in BASFI and DFI. Conclusions The study conducted by us demonstrates that the patient‘s physical function is not only dependent on signs and symptoms reported by the patient (activity of the disease), but also on the degree of structural lesions. Optimal AS treatment should not only include strategies aimed at removing pain, redness and fatigue, but also strategies aimed at preventing the formation and growth of syndesmofite. Disclosure of Interest None declared