Miracle-dz/UniFAR-FTUs huggingface dataset:
genomic epigenomic abnormality in pediatric cancer

Etiologies of pediatric cancers including childhood AML/ALL and brain tumors have been substantially explored. The findings have helped us illustrate a landscape of initiation and progression of tumor genesis, diagnosis/prognosis, and targeted treatments. Owing to the versatility of Next gen sequencing, unprecedented amount of data in cancer patients have been generated in order to characterize the complexity of genetic regulatory mechanisms. Many investigators have started to address cancerrelated questions using gene expression profiles, genetic variations, epigenetic profiles, and functional genetic regulatory elements at chromatin level. In this article, we systematically review how various genomic elements, such as gene fusion, mRNA and long non-coding RNA, may contribute to the development of pediatric cancers. Conclusion: Full understanding of direct/indirect causative and consequent effects of aberrant patterns detected via largescale platforms in personalized medicine still remain elusive as pieces of puzzles. A better understanding of the role of these different genetic or genomic components may pave the way for identification of novel therapeutic targets. DOI: 10.29011/IDDT-117. 100017
Dosimetric comparisons of intensity‐modulated radiation therapy and three‐dimensional conformal radiation therapy for left‐sided breast cancer after radical surgery

Postoperative radiotherapy for breast cancer is an effective way to control tumor recurrence; however, there are advantages and disadvantages to different radiotherapy techniques. This study compared dosimetry differences between intensity‐modulated radiation therapy (IMRT) and three‐dimensional conformal radiation therapy (3D‐CRT) plans after radical surgery for left‐sided breast cancer to provide guidance for clinicians to select a radiotherapy technique.
The Levels of Inflammatory Markers (IL-6, CRP), Homocysteine and Lipid Profile in Hemodialysis Patients, Isfahan

BackgroundCardiovascular disease (CVD) and inflammation are among the most common causes of mortality in dialysis patients. Factors such as chronic inflammation, dyslipidemia and elevated homocysteine levels may underlie the increased risk of CVD.ObjectivesThis study aimed to investigate levels of inflammatory markers, homocysteine, lipid profile, WBC, and BMI levels in hemodialysis patients compared with the control subjects in Isfahan.MethodsA total of 32 hemodialysis patients and 32 healthy subjects were selected randomly and their serum levels of IL-6, CRP, homocysteine, and lipid profiles were measured.ResultsAccording to the results, most of the studied hemodialysis patients compared to the healthy subjects had non-normal amounts of IL-6, CRP, and homocysteine i.e., higher than healthy subjects (P 0.05). A significant difference of BMI was observed between the normal subjects and the patients; thus, this factor in patients was less than what was in the healthy group (P: 0.001 < 0.05). ConclusionsThe results demonstrated that in most patients the levels of factors IL-6, CRP, and homocysteine were abnormal compared to the healthy group. In addition, the risk of developing cardiovascular and inflammatory disease as well as dyslipidemia in these patients is higher than normal
The position of the inferior vena cava-right atrium junction on simple radiography: implication for optimal veno-venous extracorporeal membrane oxygenation cannula tip position.

Background Extracorporeal membrane oxygenation (ECMO) is increasingly used. For effective oxygenation, position of cannula tip is important. The objective of this study is to identify the position of the inferior vena cava-right atrium junction (IRJ) using the vertebral body unit (VBU) and carina. This may be useful if applied to the assessment of ECMO cannula tip positions. Method A total of 182 patients who underwent chest computed tomography (CT) and supine chest radiography (CXR) between January 2017 and July 2018 were included, who had not previously received ECMO support. The position of the IRJ was evaluated using VBU and the efficacy of the VBU for locating the IRJ with the carina was analyzed. Result The mean distance (SD) from carina to IRJ was 79.2 (9.6) mm on chest CT. The mean distance in VBUs (SD) at the level of the carina was 22.3 (1.5) mm on chest CT and 23.3 (2.1) mm on CXR. The mean IRJ position was 3.6 VBUs below the carina on CT and 3.4 VBUs below on CXR with 95% limits of agreement between -0.05 and 0.5. Conclusions The mean position of the IRJ was estimated to be 3.4 VBUs below the carina on supine CXR. This may be useful if applied to the assessment of ECMO cannula tip positions.
Face of the Myocardial Infarction and Diabetes: Epidemiological and Clinical Aspects in the Cardiology Department of the University Hospital Ignace Deen about 46 Cases

The purpose of this study was to describe myocardial infarction in diabetics at the Cardiology Department Ignace Deen. Introduction: New international recommendations defined myocardial infarction, any coronary syndrome accompanied by a modification of cardiac troponin even minimal Tc or Ic [1]. Then for diabetes is defined by the World Health Organization (WHO) a blood glucose greater than 1.10 g/l and/or capillary blood glucose greater than 2.26 g/l after eight hours of fasting [2]. Patients and Methods: Were eligible for both male and female patients at any age admitted to cardiology for myocardial infarction and receiving an ECG echocardiogram; A biological evaluation including blood glucose and troponin Tc or Ic. Discussion: The risk of myocardial infarction is clearly increased in diabetics and is a determinant of coronary heart disease severity and a potential test for other cardiovascular risk factors at the Ignatius Deen Cardiac Department with a frequency of 16.08%. Our result is lower than that of DIOUMM et al. in the Fanh cardiology department of Dakar, Senegal [6], which should reduce the frequency of 22.3%. The high frequency of this pathology in the study DIOUMM is related to the size of their sample on the one hand and secondly the duration of the study, the service capacity on the other hand that could be explained. Conclusion: Diabetes mellitus is a scary medium and long-term disease that causes complications. In addition to infectious and metabolic complications, heart and coronary heart attacks are becoming more common. The tare is dominated by atherosclerosis, which must be prevented through the analysis of diabetic responsibility, with cardiovascular control of risk factors and monitoring of myocardial ischemia, and good cooperation between diabetes specialists, cardiologists and patients.
Prevalence of asthma and association with the allergic rhinitis among the patients attending a tertiary care hospital of district Varanasi: a cross sectional study

Background: The prevalence of Bronchial Asthma and Allergic Rhinitis is increasing not only in developing countries but also in developed as well. These two has been the subject of several epidemiological investigations and found an overlapping of symptoms between both diseases.Methods: Present study conducted on the patients attending the OPD of Department of TB and chest, Institute of Medical Sciences, Banaras Hindu University, Varanasi and confirmed diagnosis of asthma and allergic rhinitis were made using spirometry and nasal-endoscopy respectively.Results: 110 participants of age between 15 to more than 56 years were included attending the OPD of Department of TB and Chest with signs and symptoms related to the asthma. 32(29.09%) participants were age group of 15-25 years, 34(30.09%) of 26-35 years,18(16.36%) of 36-45 years and 15(14%) participants were from age group of 46-55years and rest 11(9%) were of 56years and above. common symptom was found nasal discharge 62(79.48%) participants followed by headache which was there in 59(75.64%) participants, excessive sneezing was found in 54(69.23%) participants and facial, postnasal discharge was found in 48(61.53%) of participants . Only 6(5.45%) participants had confirmed asthma. 6 asthmatic participants undergone the nasal endoscopy and out of 6(100%), 4(66.66%) had confirmed the diagnosis of allergic rhinitis but association was not found statistically significant.Conclusions: The prevalence of bronchial asthma was higher among the younger age group Due to the overlapping of the symptoms between asthma and allergic rhinitis confirmatory diagnostic tools should be used before starting the treatment.
Short-term effects of breastfeeding: a systematic review on the benefits of breastfeeding on diarrhoea and pneumonia mortality

WHO Library Cataloguing-in-Publication Data Short-term effects of breastfeeding: a systematic review on the benefits of breastfeeding on diarrhoea and pneumonia mortality. 1.Breast feeding. 2.Infant mortality. 3.Respiratory tract infections – prevention and control. Requests for permission to reproduce or translate WHO publications – whether for sale or for non-commercial distribution – should be addressed to WHO Press through the WHO web The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. The named authors alone are responsible for the views expressed in this publication.
STUTTERING: CEREBRAL DOMINANCE AND THE DICHOTIC WORD TEST

A considerable amount of research suggests that stuttering is a consequence of genetically determined malfunctioning of the auditory feedback control of speech. The anatomical details of this proposed lesion are not known, and the possibility that it might be a simple lack of cerebral dominance for speech comprehension was investigated in 60 stutterers by using the dichotic word test.
PERSONALIZED COGNITIVE COUNSELING IN PREVENTING RISK BEHAVIOR AMONG MEN WHO HAVE SEX WITH MEN (MSM): A LITERATURE REVIEW

The current trend of HIV infection shows an increase in cases among men who have sex with men (MSM). Risk behavior in MSM has shown a high prevalence of moderate and worrying risk behaviors for HIV infection, including unprotected anal intercourse (UAI) and drug use. This literature review aims to explore the effectiveness of Personalized Cognitive Counseling (PCC) interventions in reducing risk behaviors for HIV transmission to MSM. Articles discussed in this literature study were obtained from several databases using the keywords “personalized cognitive counseling," “men who have sex with men," and "risk behavior. " Cognitive counseling interventions are effective in reducing episodes of anal intercourse. Adapted Personalized Cognitive Counseling (PCC) intervention also has been effective in reducing sexual risk behavior in drug users MSM. This intervention is possible and essential to developing in dealing with risk behavior in MSM that tends to increase in its population. Keywords: cognitive counseling, personalized cognitive counseling, men who have sex with men (MSM), risk behavior
LINC01638 lncRNA mediates the postoperative distant recurrence of bladder cancer by upregulating ROCK2

It is well established that long intergenic non-protein coding RNA 1638 (LINC01638) promotes the development and progression of breast cancer, whereas its roles in other human diseases are currently unknown. In the present study, expression of LINC01638 and ROCK2 was analyzed using quantitative PCR, ELISA and western blot. Receiver operating characteristic curve was used for diagnostic analysis. Cell transfections were performed to analyze interactions between LINC01638 and ROCK2, while Transwell assays were performed to analyze invasion and migration of the bladder cancer HT-1197 and HT-1376 cell lines. It was observed that LINC01638 and Rho-associated, coiled-coil containing protein kinase 2 (ROCK2) were significantly upregulated in the plasma of patients with early stage (stage I and II) bladder cancer compared with in healthy controls. Upregulation of LINC01638 and ROCK2 distinguished patients with early stage bladder cancer from healthy controls. Plasma levels of LINC01638 and ROCK2 were positively correlated in patients with bladder cancer, but not in healthy controls. A follow-up study after surgical resection revealed that LINC01638 and ROCK2 were further upregulated in patients with distant recurrence, or distant and local recurrence, but not in patients with local recurrence and no recurrence. Overexpression of LINC01638 led to ROCK2 upregulation in bladder cancer cells, whereas ROCK2 overexpression did not significantly affect LINC01638 expression. Overexpression of LINC01638 and ROCK2 mediated the promoted migration and invasion of bladder cancer cells, and ROCK2 small interfering RNA silencing attenuated the enhancing effects of LINC01638 on cancer cell migration and invasion. Therefore, LINC01638 may mediate the postoperative distant recurrence of bladder cancer by upregulating ROCK2.
Agricultural Product Rating Prediction Design Based on Collaborative Filtering Algorithm

The rapid development of agricultural e-commerce has led to more and more agricultural products on the website, and the problem of information overload has become increasingly prominent. By analyzing the user's historical score data set, this paper analyzes the recommended models of different collaborative filtering algorithms and different similarity calculation formulas, predicts the rating of the new agricultural products by the given user, tests the RMSE and MAE values under different algorithms, and helps the users to recommend the preferred agricultural products, thus providing personalized service to the users.
Perceived Risk and Representations of Cardiovascular Disease and Preventive Behaviour in People Diagnosed with Familial Hypercholesterolemia

Perceived risk and representations of cardiovascular disease (CVD), and preventive behaviour of people diagnosed with Familial Hypercholesterolemia by DNA testing (N = 81) were assessed. In general, participants perceived their own CVD risk as being relatively low. While participants reported almost optimal medication adherence (99%), only 49 per cent reported following recommendations concerning diet and physical activity. Family history of CVD was associated with both risk perception and the adoption of a healthy lifestyle. In their communications with FH-screened positives, health professionals should be aware that people may underestimate CVD risk, and should stress how behaviour change can reduce the risk.
Analysis of cytological false negatives of carcinoma of cervix

Introduction: Cervical carcinoma is one of the leading malignancies affecting the women of India. Since the Papanicolaou(Pap) test can very effectively detect the prolonged phase of carcinoma in situ, current policy suggests that all women should have this test done at regular intervals. Monitoring cytohistological discrepancies is a useful quality assurance tool in cytology laboratory. Cervical cancer has been successfully reduced by routine screening and medical intervention. Aims and objectives: This present study was done to study the prevalence of cytohistological discrepancy in histologically proven cases of carcinoma cervix and to identify the causes for false negativity in the cytological examination in histologically proven cases of carcinoma cervix. Materials and Methods: This study was conducted in the Department of Pathology, Mahatma Gandhi Institute o f Medical Sciences, Sevagram, Maharashtra. This study was done on 209 biopsy proven cases of carcinoma cervix over a period of two years. The original cytological diagnosis of smears available in these cases were co-related with the biopsy results. Results: In the pre-review, in 80.3% cases the diagnosis of carcinoma was rendered on initial screening in cytology. Cytohistological discrepancies were observed in 19.6% accounting for a false negative rate of 19.6% and a false negative fraction 0.196 %. After post review, the false negative rate reduced to 11.62% and the frequency of the different types of errors were calculated. Conclusion: The level of agreement between cytology and the histology diagnosis may be used as a measure of laboratory quality. To the best of our knowledge, data on factors associated with cytohistologic discrepancy in Pap smear are limited. Therefore, we conducted this study to evaluate the factors associated with cytohistologic discrepancy in Pap smears and to determine the rate of cytohistologic discrepancy and ways to reduce the false negatives. © 2019 Published by Innovative Publication.
Seizures with Autonomic Symptoms and Sudden Unexpected Death in Epilepsy (SUDEP)

Ya z’fl ma Ad re si/Ad dress for Cor res pon den ce: Dr. Rabia Gökçen Gözübatık Çelik, İstanbul Bakırköy Prof. Dr. Mazhar Osman Ruh Sağlığı ve Sinir Hastalıkları Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, İstanbul, Türkiye Tel. : +90 554 937 00 87 E-posta: gokcen3@hotmail.com ORCID: orcid.org/0000-0002-8186-8703 Ge lifl Ta ri hi/Re cei ved: 22.10. 2018 Ka bul Ta ri hi/Ac cep ted: 15.02. 2019 ©Telif Hakkı 2019 Türk Nöroloji Derneği Türk Nöroloji Dergisi, Galenos Yayınevi tarafından basılmıştır. Otonom sinir sistemi bilinçli kontrolün olmadığı bir sistemdir. Sempatik ve parasempatik olmak üzere iki bölümden oluşur. Santral sinir sisteminde otonom sistemden sorumlu ana merkez hipotalamustur. Otonom nöbet semiyolojisinde rol alan diğer anatomik yapılar singulat girus, amigdala, paraventriküler nükleustur. Otonom epilepsilerin fizyopatolojisinde yer alan santral otonom ağ non-dominant hemisferde temsil edilirken otonom bulgular temporal ve insuler lob epilepsilerde sıktır. Hastalarda klinik olarak; kan basıncı değişiklikleri, kalp ritim bozuklukları (taşikardi, bradikardi, aritmi, asistoli), solunumsal değişiklikler (apne, hipopne, bradipne), tükürük artışı, kusma/öğürme, pilo-ereksiyon, terleme artışı, midriazis/miyozis, tükürme, acil miksiyon, su içme, genital otomatizm, barsak motilite bozuklukları nöbet öncesi/sırası/ve sonrasında görülebilen otonom semptomlardır; temporal lob epilepsisinde daha sıktır. Otonom nöbetli hastaların ani ölüm riski de diğer epilepsi hastalarına göre daha fazladır. Epilepside ani beklenmedik ölüm (SUDEP); epilepsi hastasında boğulma, travma ve status epileptikus dışlandıktan sonra; ani, beklenmedik, görgü tanığı ya da ölüm sırasında nöbet kanıtı olsun olmasın meydana gelen; postmortem incelemelerde ölüme neden olan yapısal veya toksik bir sebep saptanmayan ölüm olarak tanımlanır; epilepsideki ölümlerin %17’sinden sorumludur. SUDEP’nin etiyolojisinde; altta yatan postiktal kardiyorespiratuvar disfonksiyon olduğu öne sürülür. Ani ölüm riski için SpO2 eşik değerinin %80-86 olduğu bildirilirken, iktal olaylar, otonom sistemin kronik aktivasyonu nedeniyle ölümcül aritmileri tetiklerler. Özellikle uykuda olan jeneralize tonik klonik nöbetler, dirençli epilepsiler SUDEP ile ilgilendirilen risk faktörlerindendir. Kardiyorespiratuvar bulgulu otonom semptomlu nöbetlere bu risklere katkıda bulunabileceği açısından dikkat edilmelidir. Anahtar Kelimeler: Otonom nöbetler, epilepsi, SUDEP
Dual GIP–GLP1-Receptor Agonists In The Treatment Of Type 2 Diabetes: A Short Review On Emerging Data And Therapeutic Potential

Abstract The need for efficient and safe therapy to improve such metabolic diseases as obesity and type 2 diabetes mellitus is currently unmet. The development of dual GIPR–GLP1R coagonists that bind to either one or the other receptor (sequence-mixed dual agonists) has emerged as an innovative therapeutic strategy for obesity and type 2 diabetes. Combined activation of both receptors may act synergistically providing additive effects on glucose and body weight in comparison of GLP1 analogues alone. Preclinical studies have confirmed that GIPR–GLP1R coagonists improve several hallmarks of metabolic syndrome, such as obesity, hyperglycemia, and dyslipidemia. These metabolic benefits have been translated from mice to nonhuman primates and humans. Recent clinical trials have shown that coagonists induce significant benefits on body weight, fasting, and postprandial glucose levels, insulin sensitivity, and total cholesterol. Combined GIP- and GLP1R activators have the potential to become a treatment option for patients with type 2 diabetes.
Techniques for Treating Bilateral Breast Cancer Patients Using Pencil Beam Scanning Technology.

Purpose Patients with bilateral breast cancer (BBC), who require postmastectomy radiation therapy or radiation as part of breast conservation treatment, present a unique technical challenge. Even with modern techniques, such as intensity modulated radiation therapy or volumetric modulated arc therapy (VMAT), adequate target coverage is rarely achieved without the expense of increased integral dose to important organs at risk (OARs), such as the heart and lungs. Therefore, we present several BBC techniques and a treatment algorithm using intensity-modulated proton therapy (IMPT) for patients treated at our center. Materials and Methods We describe 3 different BBC treatment techniques using IMPT on patients treated at our center, with comparison VMAT plans to demonstrate the dosimetric benefit of proton therapy in these patients. Following RADCOMP (Radiation Therapy Oncology Group, Philadelphia, Pennsylvania) guidelines, a single physician approved all target volumes and OARs. Plans were designed so that ≥ 95% of the prescribed dose covered ≥ 95% of all targets. Parameters for dosimetric volume histograms for the clinical targets and OARs are reported for the 2 radiation methods. Results All methods demonstrated acceptable target coverage with 95% of the prescription planning target volume reaching a mean (± SD) of 98.0% (± 0.87%) and 97.5% (± 2.39%), for VMAT and IMPT plans, respectively. Conformity and homogeneity were also similar between the 2 techniques. Proton therapy provided observed improvements in mean heart dose (average heart mean [SD], 9.98 Gy [± 0.87 Gy] versus 2.12 Gy [± 0.96 Gy]) and total lung 5% prescription dose (V5; mean [SD] total lung V5, 97.9% [± 2.84%]), compared with 39.8% [± 9.39%]). All IMPT methods spared critical OARs; however, the single, 0° anterior-posterior plan allowed for the shortest treatment time. Conclusion Both VMAT and all 3 IMPT techniques provided excellent target coverage in patients with BBC; however, proton therapy was superior in decreasing the dose to OARs. A single-field optimization approach should be the IMPT method of choice when feasible.