Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of the transcriptional activator AppY in regulation of the cyx appA operon of Escherichia coli by anaerobiosis, phosphate starvation, and growth phase

Transcriptional lacZ fusions have been used to analyze the regulation of the appA operon of Escherichia coli. The appA operon contains the genes cyxA and cyxB, coding for the putative third cytochrome oxidase, and appA, encoding acid phosphatase. The analysis showed that the cyxAB and the appA genes are cotranscribed from a potentially strong promoter, Pcyx, located immediately upstream of cyxA and that the operon in addition contains an internal promoter, PappA, contributing significantly to the transcription of the appA gene. The two promoters were both induced by starvation for Pi and by entry into stationary phase. The cyx promoter was in addition found to be activated by anaerobic growth conditions. The product of the previously identified appY gene, which when present on a high-copy-number plasmid stimulates synthesis of acid phosphatase, was shown to activate the cyx promoter. An insertion mutation in the appY gene was constructed in vitro and recombined into the chromosome. The appY mutation eliminated induction of the cyx promoter by anaerobiosis and severely reduced induction of this promoter by phosphate starvation and upon entry into stationary phase but had no effect on induction of the appA promoter. The appY mutation had no effect on survival in stationary phase, nor did it have any effect on growth rate or yield under aerobic or anaerobic conditions. The possibility that AppY is a third global regulator of energy metabolism genes is discussed.
Key Aspects for Characterizing Device Inherent IMD in GaN HEMTs

The paper proposes an IMD characterization methodology representing a further refinement in the state-of-the-art of source-/load-pull for precise evaluation of intrinsic linearity in GaN HEMTs for 3G wideband applications. Presenting constant IF and RF load across wide modulation bandwidth is extremely difficult. By mimicking the amplifier environment, the RF bias tee which has significant influence on measured IMD products due to its IF and RF terminations, should be placed in the proximity of the device reference plane for acquiring true IMD characteristics of the active device. This has demonstrated means to mitigate IF harmonics at the baseband and IMD products at RF. As a consequence, a straightforward PA design guidelines are deduced through experimental optimization of bias and matching networks.
Incremental mining of frequent power consumption patterns from smart meters big data

The key elements for understanding power consumption of a typical home are related to the activities that users are performing, the time at which appliances are used, and the interdependencies with other appliances that may be used concurrently. This information can be extracted from context rich smart meters big data. However, the main challenge is how to mine complex interdependencies among different appliances usage within a home where multiple concurrent data streams are occurring. Furthermore, generation of energy consumption data from a smart meter is an ongoing continuous process and over period of time inter-appliance associations can change or new ones can establish. In this paper, we propose incremental mining of frequent power consumption patterns from smart meters big data. Our model exploits the benefits of pattern growth strategy and mine in quantum of 24 hour period, i.e. frequent patterns are extracted from data comprising of appliance usage tuples for 24 hours period, in a progressive manner. The details and the results of evaluating the proposed mechanism using real smart meters dataset are presented in this paper.
Locally Advanced, Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline.

PURPOSE To provide evidence-based recommendations to oncologists and others for treatment of patients with locally advanced, unresectable pancreatic cancer. METHODS American Society of Clinical Oncology convened an Expert Panel of medical oncology, radiation oncology, surgical oncology, gastroenterology, palliative care, and advocacy experts and conducted a systematic review of the literature from January 2002 to June 2015. Outcomes included overall survival, disease-free survival, progression-free survival, and adverse events. RESULTS Twenty-six randomized controlled trials met the systematic review criteria. RECOMMENDATIONS A multiphase computed tomography scan of the chest, abdomen, and pelvis should be performed. Baseline performance status and comorbidity profile should be evaluated. The goals of care, patient preferences, psychological status, support systems, and symptoms should guide decisions for treatments. A palliative care referral should occur at first visit. Initial systemic chemotherapy (6 months) with a combination regimen is recommended for most patients (for some patients radiation therapy may be offered up front) with Eastern Cooperative Oncology Group performance status 0 or 1 and a favorable comorbidity profile. There is no clear evidence to support one regimen over another. The gemcitabine-based combinations and treatments recommended in the metastatic setting (eg, fluorouracil, leucovorin, irinotecan, and oxaliplatin and gemcitabine plus nanoparticle albumin-bound paclitaxel) have not been evaluated in randomized controlled trials involving locally advanced, unresectable pancreatic cancer. If there is local disease progression after induction chemotherapy, without metastasis, then radiation therapy or stereotactic body radiotherapy may be offered also with an Eastern Cooperative Oncology Group performance status ≤ 2 and an adequate comorbidity profile. If there is stable disease after 6 months of induction chemotherapy but unacceptable toxicities, radiation therapy may be offered as an alternative. Patients with disease progression should be offered treatment per the ASCO Metastatic Pancreatic Cancer Treatment Guideline. Follow-up visits every 3 to 4 months are recommended. Additional information is available at www.asco. org/guidelines/LAPC and www.asco. org/guidelines/MetPC and www.asco. org/guidelineswiki.
[REHACOP: a cognitive rehabilitation programme in psychosis].

INTRODUCTION In this work we present REHACOP, a programme of cognitive rehabilitation in psychosis. MATERIALS AND METHODS The foundation of the REHACOP programme (its structure, materials, aims, work methodology and means of implementation) are described in detail. RESULTS AND CONCLUSIONS This new therapeutic tool is presented with the aim of being of use to guide professionals who seek to design an intervention of this kind in samples of patients with schizophrenia or other pathologies.
Les entreprises familiales face à la responsabilité sociale de l'entreprise (RSE) : une étude de leurs comportements dans le contexte tunisien post révolution

Les entreprises familiales sont appelees aujourd'hui a assumer leur role societal tout comme les autres types d'entreprises surtout avec le developpement du mouvement societal. Il s'agit donc d'adopter de nouveaux comportements en mettant en œuvre de nouvelles pratiques de gestion. Cette etude essaie d'analyser le comportement societal adopte par les entreprises familiales apres la revolution tunisienne. L'etude menee sur 9 entreprises familiales montre qu'avant la revolution, celles-ci adoptaient un comportement plutot attentiste ou la dimension societale est quasi exclue. Apres la revolution, le comportement adaptatif est adopte. Avec plus d'experience en matiere de gestion societale, les dirigeants reussiront a assurer la logique win-win et adopteront par consequent un comportement qualifie de proactif qui se base sur l'anticipation. Cette recherche propose un processus d'evolution des comportements des entreprises familiales envers les pressions societales allant du comportement attentiste au comportement proactif en passant par le comportement adaptatif.
Incidence of community-acquired pneumonia requiring hospitalization. Results of a population-based active surveillance Study in Ohio. The Community-Based Pneumonia Incidence Study Group.

BACKGROUND Pneumonia is the leading cause of death due to infectious diseases in the United States; however, the incidence of most infections causing community-acquired pneumonia in adults is not well defined. METHODS We evaluated all adults, residing in 2 counties in Ohio, who were hospitalized in 1991 because of community-acquired pneumonia. Information about risk factors, symptoms, and outcome was collected through interview and medical chart review. Serum samples were collected from consenting individuals during the acute and convalescent phases, and specific etiologic diagnoses were assigned based on results of bacteriologic and immunologic tests. RESULTS The incidence of community-acquired pneumonia requiring hospitalization in the study counties in 1991 was 266.8 per 100,000 population; the overall case-fatality rate was 8.8%. Pneumonia incidence was higher among blacks than whites (337.7/100,000 vs 253.9/ 100,000; P < .001), was higher among males than females (291.4 vs 244.8; P < .001), and increased with age (91.6/100,000 for persons aged < 45 years, 277.2/ 100,000 for persons aged 45-64 years, and 1012.3/ 100,000 for persons aged > or = 65 years; P < .001). Extrapolation from study incidence data showed the projected annual number of cases of community-acquired pneumonia requiring hospitalization in the United States to be 485,000. These data provide previously unavailable estimates of the annual number of cases that are due to Legionella species (8000-18,000), Mycoplasma pneumoniae (18,700-108,000), and Chlamydia pneumoniae (5890-49,700). CONCLUSIONS These data provide information about the importance of community-acquired pneumonia and the relative and overall impact of specific causes of pneumonia. The study provides a basis for choosing optimal empiric pneumonia therapy, and allows interventions for prevention of pneumonia to be targeted at groups at greatest risk for serious illness and death.
Arguments for and against the Role of Glucose Variability in the Development of Diabetes Complications

There is now unequivocal evidence that improving glycemic control in both type 1 and type 2 diabetes reduces the likelihood of developing the micro- and macrovascular complications of the disease. However, it is still unclear whether a patient with very variable glucose is at any different a risk of these problems than someone who has the same mean glucose but much more stable glycemia. This article reviews the evidence that exists to both support and refute the claim that increased glucose variability should be regarded as an independent risk factor for the development of diabetic vascular disease.
Structural connectome topology relates to regional BOLD signal dynamics in the mouse brain

Brain dynamics are thought to unfold on a network determined by the pattern of axonal connections linking pairs of neuronal populations; the so-called connectome. Prior work has indicated that structural brain connectivity constrains pairwise correlations in brain dynamics (also called functional connectivity), but it is not known whether inter-regional axonal connectivity is related to the intrinsic dynamics of individual brain areas. Here we investigate this relationship using a weighted, directed mesoscale mouse connectome from the Allen Mouse Brain Connectivity Atlas and resting state functional MRI (rs-fMRI) time-series data measured in 184 brain regions in eighteen anesthetized mice. For each brain region, we measured degree, betweenness, and clustering coefficient from weighted and unweighted, and directed and undirected versions of the connectome. We then characterized the univariate rs-fMRI dynamics at each brain region by computing 6 930 time-series properties using the time-series analysis toolbox, hctsa. After correcting for regional volume variations, strong and robust correlations between structural connectivity properties and rs-fMRI dynamics were found only when edge weights were accounted for, and were associated with variations in the autocorrelation properties of the rs-fMRI signal. The strongest relationships were found for weighted in-degree, which was positively correlated to the autocorrelation of fMRI time series at time lag τ = 34s (partial Spearman correlation ρ = 0.58), as well as a range of related measures such as relative high frequency power (f > 0.4 Hz: ρ= −0.43). Our results indicate that the topology of inter-regional axonal connections of the mouse brain is closely related to intrinsic, spontaneous dynamics such that regions with a greater aggregate strength of incoming projections display longer timescales of activity fluctuations.
The language focus of Science education integrated with English learning

Global education demands being directed to scientific literacy and language proficiency, research on the school integration of Science and English and on the language focus for Science education is highly relevant. One educational approach is CLIL, aiming both at learners’ Content and Language acquisition. The main objective of our work – framed in the socio-constructivism and designed as a case study – is to understand what teaching strategies and classroom interactions have been developed and can be promoted in the “English Plus” project in one Portuguese school to support students, when Science education is integrated with English use. Context characterization shows the importance of developing a language-aware teaching approach to improve the subject education and student learning. To foster that, an instrument has been constructed and is presented here.
Leader-following consensus for linear discrete-time multi-agent systems subject to static networks

The leader-following consensus problem for linear discrete-time multi-agent systems subject to static networks has been studied in the literature using H∞ Riccati inequality design and H2 Riccati equation design, respectively. However, these methods involve some less tractable conditions and need to solve some type of Riccati equation or inequality. In this paper, we further study the leader-following consensus problem for linear discrete-time multi-agent systems subject to static networks for the case where the leader system is marginally stable. By showing the Schur stability of some graph matrix, which can be viewed as the discrete-time counterpart of H matrix encountered in continuous-time leader-following consensus problem, we solve our problem with a straightforward method, which is the reminiscent of the same problem for continuous-time multi-agent systems.
Sorafenib in non-small cell lung cancer

Introduction: Conventional chemotherapy has reached a plateau of effectiveness for the treatment of non-small cell lung cancer (NSCLC). Patients with EGFR mutation or ALK translocations will benefit significantly from agents targeting these pathways, however, only 20% of western NSCLC patients have these mutations. Anti-VEGF antibody bevacizumab was approved for advanced NSCLC, but the clinical benefits are modest and all patients eventually develop resistance. Multi-targeted tyrosine kinase inhibitors (TKI) may offer more efficient inhibition of angiogenesis by blocking overlapping pathways and they may also have direct anti-tumor effects. Sorafenib is approved in the treatment of renal cell carcinoma and hepatocellular carcinoma and is now under investigation in the treatment of NSCLC. Areas covered: This review summarizes recent studies evaluating sorafenib in the treatment of NSCLC. Expert opinion: Sorafenib has shown anti-tumor activity in NSCLC. However, because NSCLC is complex and molecularly heterogeneous, it is very likely that only a subset of NSCLC patients will benefit from sorafenib, and so it is imperative to discover biomarkers to select patients who will probably benefit from sorafenib. Combination with other agents targeting parallel and compensatory pathways, such as EGFR inhibitors, may offer broader coverage and better disease control.
Fraud prevention initiatives in the Nigerian public sector: Understanding the relationship of fraud incidences and the elements of fraud triangle theory

Purpose Detecting and preventing fraud are challenging and risky tasks, especially in a fast developing economy such as Nigeria. The efforts become crucial in the government sectors since they involve public’s trust and resources. The study was conducted to examine the relationships between the fraud incidence and the elements of Fraud Triangle Theory (FTT) with the aim of combating current fraud outrages in the Nigerian public sector. Design/methodology/approach A survey was conducted and 302 questionnaires were distributed to the staffs of the departments of accounting, internal auditing and investigation of ten selected ministries, departments and agencies of Kano State, Nigeria. Structural Equation Modelling (SEM) was used to analyse the data. Findings The study reveals a significant relationship between three elements of FTT and fraud incidences in the Nigerian public sectors (p-value <0.001 for pressure and opportunity, and p-value = 0.024 for rationalisation). Practical implications The findings.
Second Language Creative Writers: Identities and Writing Processes

For Jacques Derrida, language is a habitat that contours one’s “ipseity” (1). He addressed the complexity generated in one’s sense of the self when one speaks a language that is not one’s own, but a legacy of the colonial experience which has erased the language of the colonized. Yan Zhao’s monograph entitled Second Language Creative Writers: Identities and Writing Processes explores the configuration of writer identities and writer voices of Second Language Creative Writers who have access to both their first and second languages. The linguistic habitat of these second language creative writers is a mélange of various linguistic paradigms that have played a pivotal role in the constitution of their subjectivities. As Zhao meticulously traces the connection between the identities and the cognitive writing processes of 15 advanced level L2 Creative Writers in the United Kingdom through discourse analysis, this important work does not only cover how social processes and human cognition are interconnected, it also operates as a work that could function as a base for devising new ways of analyzing the subjective coordinates of L2 writers vis-à-vis the target language and also the socio-political contexts within which the target language is spoken.
Sleep Complaints in Late Pregnancy and the Recurrence of Postpartum Depression

This study evaluated the relationship between sleep quality in late pregnancy and recurrence of postpartum major depression (PPMD) through 28 weeks postpartum. The Pittsburgh Sleep Quality Index (PSQI) at 36 weeks gestation was assessed in 51 non-depressed women with a history of PPMD; recurrence was determined by the 21-item Hamilton Rating Scale for Depression and the Schedule for Affective Disorders and Schizophrenia. Sleep quality in late pregnancy was not related to recurrence per se, but it was related to timing of recurrence (Kruskal–Wallace = 9.78, p = .008). Rapid recurrence (within 4 weeks post delivery) was preceded by fewer sleep complaints (mean PSQI for early recurrers = 4.8 vs. 7.3 for non-recurrers, p = .09). Recurrence after 4 weeks postpartum was preceded by more sleep complaints in late pregnancy (mean PSQI for late recurrers = 9.9 vs. 7.3 for non-recurrers, p = .02). Sleep quality in late pregnancy may help in identifying women at risk for a PPMD recurrence.
Runtime Integration and Testing for Highly Dynamic Service Oriented ICT Solutions -- An Industry Challenges Report

Modern Information and Communications Technology (ICT) solutions are often widely distributed and highly dynamic service oriented architectures (SOA) with stringent availability requirements. Availability implies that SOA must be reconfigured, updated and maintained during runtime, while retaining their overall operational integrity. This requires that much of the adaptation, integration, configuration and testing activities typically performed offline, during development time, now have to be done online, during runtime. Current component-based runtime platforms such as SOA realize the technological foundations for runtime reconfiguration and maintenance.However, because software engineering methodology has not kept pace with the rapid leap forward in platform technology, adequate methods, techniques and tools for dealing with runtime integration and testing are not yet available.This paper discusses the industry challenges and open issues of integrating and testing SOA infrastructures during runtime.
You Seize What Pops Up: A Qualitative Investigation of the Core Features of School-Based Agricultural Education Professional Development.

Desimone’s core features of professional development (PD) guides the PD for teachers. The purpose of this study was to examine the PD practice of School-Based Agricultural Education (SBAE) teachers in the enthusiastic and growing career stage. Semi-structured telephone interviews were conducted with five teachers from five different states. The transcriptions of the interviews were coded using content analysis to determine if Desimone’s core features were evident in the PD practice of enthusiastic and growing teachers. The codes for four teachers indicated that they were in the enthusiastic and growing career stage and were included in the content analysis. The respondents indicated PD for SBAE teachers included collective participation, content focus, and active learning. Discrepancy was found between Desimone’s core features of PD of coherence and duration. PD should be designed in SBAE to include the core features of PD. A Team Ag Ed. approach to planning and implementing PD is recommended to increase coherence and promote participation in PD offerings. Efforts should also be made to incorporate school district and subject-specific initiatives. Further investigation is needed to explore Desimone’s full model of PD for SBAE teachers.
New nanomicelle curcumin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment

Abstract Context: A stable topical ophthalmic curcumin formulation with high solubility, stability, and efficacy is needed for pharmaceutical use in clinics. Objectives: The objective of this article was to describe a novel curcumin containing a nanomicelle formulation using a polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol (PVCL–PVA–PEG) graft copolymer. Methods: Nanomicelle curcumin was formulated and optimized and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vitro cellular uptake/in vivo corneal permeation, and in vitro antioxidant activity/in vivo anti-inflammatory efficacy. Results: The solubility, chemical stability, and antioxidant activity were greatly improved after the encapsulation of the PVCL–PVA–PEG nanomicelles. The nanomicelle curcumin ophthalmic solution was simple to prepare and the nanomicelles are stable to the storage conditions, and it had good cellular tolerance. Nanomicelle curcumin also had excellent ocular tolerance in rabbits. The use of nanomicelles significantly improved in vitro cellular uptake and in vivo corneal permeation as well as improved anti-inflammatory efficacy when compared with a free curcumin solution. Conclusions: These findings indicate that nanomicelles could be promising topical delivery systems for the ocular administration of curcumin.
CLINICIAN ’ S CORNER USERS ’ GUIDES TO THE MEDICAL LITERATURE HowtoUseanArticleAboutQuality Improvement

You, the medical director of an intensive care unit (ICU), discover that mortality has increased for patients with sepsis. You are considering a quality improvement (QI) initiative to improve the care and outcomes of your patients. However, you are concerned that many QI studies have weak designs and poor data quality and often overestimate potential benefits. Before beginning, you decide to identify and evaluate existing QI interventions.