Miracle-dz/UniFAR-FTUs huggingface dataset:
Memoria Colectiva e Historia Universal: Evaluación Subjetiva e Importancia de Eventos y Personajes

La memoria colectiva hace referencia a como los grupos sociales recuerdan, olvidan o se reapropian del conocimiento del pasado social. Siguiendo los estudios previos que toman a la historia como objeto de representacion social, se analiza como los eventos y personajes de la historia universal se agrupan en funcion de su evaluacion e importancia (n = 379, 55.7% mujeres, edad = 18-69). Los datos fueron recolectados a traves de internet utilizando un cuestionario autoadministrado. Se presentaron 28 eventos y 24 personajes de la historia universal frente a los cuales los participantes debian indicar en que medida les parecian positivos o negativos y que importancia les atribuian. Se efectuaron dos analisis de conglomerado jerarquico de variables, uno para evaluacion subjetiva y otro para importancia. Para la evaluacion subjetiva se obtuvieron tres conglomerados y para importancia se hallaron dos conglomerados. Los estimulos evaluados de forma mas negativa pertenecen al ultimo siglo y estan relacionados con guerras o problemas politicos y economicos. Aquellos evaluados de forma mas favorable se asocian con descubrimientos o con la lucha contra la opresion (abolicion de la esclavitud, sistema democratico). En cuanto a la importancia atribuida, todos los estimulos presentados obtuvieron una alta importancia, alcanzando los eventos puntuaciones mas elevadas que los personajes. Los eventos y personajes considerados mas importantes se relacionaron con avances en los derechos del hombre y la libertad, el conocimiento y cambios en la vida social. Estos hallazgos se discuten en el marco de la memoria colectiva.
Görsel Sanatlar Eğitiminde Edebiyat Ürünlerinin Öğrenci Çalışmalarına Etkisi

Bu arastirma, ortaokul ogrencilerinin gorsel sanat calismalarina edebiyat urunlerinin etkisi olup olmadigini, etkisi var ise hangi duzeyde oldugunu belirlemek amaciyla yapilmistir. Arastirma 2016-2017 egitim ogretim yilinda Kastamonu ilinde bulunan dort ortaokulun 6. sinifinda ogrenim goren ogrencileri ile sinirlidir. Arastirma ontest ve sontest olmak uzere calismanin tamamina katilan ve calismalarini (resimlerini) tamamlamis olan 50 ogrenciyi kapsamaktadir. Arastirmanin uygulama konusu edebiyat urunlerinden olan fabl, atasozu-deyim ve efsane turleri ile sinirlandirilmistir. Ogrenci resimleri, kuru boya teknigi ile gerceklestirilmistir. Arastirmada, nicel arastirma yontemlerinden deneysel bir tur olan, tek denekli arastirma modeli icinde yer alan tek gruplu ontest-sontest model kullanilmistir. Ayrica ogrenci calismalari nitel arastirma kapsaminda betimlenerek yorumlanmistir. Ayrica ogrenci calismalari nitel arastirma kapsaminda betimlenerek yorumlanmistir. Arastirmanin veri toplama araclari, ogrencilerin yapmis oldugu serbest calismaya ait resimler (ontest) ve edebiyat urunlerinin kullanimina yonelik resimlere (sontest) dayanmaktadir. Ogrenci calismalari; gorsel sanatlar egitimi uygulamalarinda edebiyat urunlerinin etkisini belirlemek amaciyla gelistirilmis ve yayinlanmis olan dereceli puanlama anahtari (rubrik) kullanilarak, uc alan uzmani tarafindan degerlendirilmistir. Veri toplama araclarindan elde edilen veriler, bilgisayar ortamina gecirilmis ve ‘SPSS’ analiz programi kullanilarak analiz edilmistir. Gorsel sanatlar egitimi uygulamalarinda edebiyat urunlerinin etkisini belirlemeye yonelik dereceli puanlama anahtari icerisindeki kriterlere dayali ontest ve sontest puanlarinin karsilastirilmasi, Wilcoxon isaretli siralar testi ile incelenmistir. Arastirmadan elde edilen verilere gore; nicel arastirma yontemlerinden deneysel bir tur olan, tek denekli arastirma modeli icinde yer alan tek gruplu ontest-sontest test puanlari arasinda butunluk ve gorsel devamlilik, hareket ifadesi, imge zenginligi, renk kullanimi, ayrintilara yer verme, mekân ifadesi, kompozisyon, yaratici dusunme, stereotip bicim kullanimi kriterleri acisindan istatistiksel olarak sontest lehine anlamli bir fark ortaya cikmistir.
Role of Mortgage Financing in the Growth of Real Estate in Nairobi Metropolis, Kenya

rate that is being charged on the funds provided for such development purposes. Whereas the first world countries use stocks and bonds to finance real estate, Kenya predominantly uses mortgage financing. Demand for real estate and Abstract: Real estate business is an undertaking that has been perceived by many as a project that needs a lot of capital to initiate. In Kenya, investing in real estate hasn't been such a huge venture until the last 10 years. This research therefore aimed at establishing the perceived role of mortgage financing on the growth of real estate in Kenya with a focus in Nairobi Metropolitan area. It is often difficult to fund big projects in real estate solely from personal savings. There is a need to use other sources of finance such as equity or self-financing, or mortgage from financial institutions like commercial banks, insurance companies and mortgage institutions or venture capital. This research paper was guided by the objective; To assess influence of mortgage financing option on the growth of real estate in Nairobi Metropolis. This study used primary data collected from registered developers in Kenya with an interest in Nairobi Metropolis. The sample size was 81 out of a population of 100 developers registered with Kenya Property Developers Association. The study employed descriptive research design and data was analyzed through multiple regression analysis. This study found out that the variable only explained 7.1% of the growth of Real estate in Kenya. Other factors outside this research explain 92.9% of the growth in real estate. Due to the low explanation the researcher employed confirmatory factor analysis to determine model perfect of fit. The study found mortgage financing as a variable had a good fit. From this study, then there is a need for more research on those other factors that have spurred growth in real estate in Kenya. This study was carried out during the period May to August 2019.
Otimizando o Uso de Recursos Computacionais através da Multiprogramação

Resumo. Um dos principais desafios das grandes empresas está em reduzir os custos para manter os serviços de tecnologia em pleno funcionamento. Neste sentido, diferentes abordagens têm sido propostas para otimizar o uso de recursos computacionais. Neste trabalho, mostramos como a distribuição ideal de recursos entre as aplicações pode reduzir o tempo que o computador ficará processando em até 24%, reduzindo o consumo total de energia1.
Intratumoral injection of anlotinib hydrogel enhances antitumor effects and reduces toxicity in mouse model of lung cancer

Abstract This study was conducted to determine the antitumor effects and ability of an anlotinib (AL) hydrogel (AL–HA–Tyr) to reduce toxicity in a mouse model of Lewis lung cancer (LLC). We constructed a drug carrier system for AL, verified its effectiveness and systemic safety, and provided a preliminary experimental foundation for clinical carrier transformation. AL–HA–Tyr was prepared by encapsulating AL with hyaluronic acid–tyramine (HA–Tyr) conjugates. Colony and tube formation assays showed that AL–HA–Tyr restrained the proliferation of human umbilical vein endothelial cells (HUVECs) and LLC cells, respectively, in vitro, and that AL exerted significant anti-angiogenesis and anti-tumor effects. The invasion and migration of HUVECs and LLC cells were efficiently suppressed by AL according to transwell assays. HUVEC and LLC cell-cycle and apoptosis analysis clarified the direct anti-tumor effects of AL–HA–Tyr. Mice engrafted with LLC cells in vivo were administered oral saline, oral AL, or an intratumoral injection of HA–Tyr or AL–HA–Tyr. The results showed that AL–HA–Tyr obviously reduced visceral toxicity and decreased Ki67 and VEGF-A expression in tumor cells compared with AL. Furthermore, AL–HA–Tyr significantly prolonged the survival of tumor-bearing mice. Overall, AL–HA–Tyr enhanced antitumor effects and reduced toxicity in the LLC model. It provided a foundation for the clinical transformation of drug carrier systems.
Arboreal vegetation structure and diversity in the gallery forest of the Xaltatempa river, Puebla, Mexico

Gallery forests are plant formations that develop parallel to rivers. They possess a great plant diversity; whose arboreal species are indicative of water quality. Here are described the variables of the arboreal plant life and their relationship with the water quality of the Xaltatempa river, Puebla, Mexico. To do this, six sampling units were established, each 1000 m2, separated by 2 km, where all the trees and shrubs were measured and identified in order to generate information regarding: importance value index (IVI), forestry value index (FVI), Shannon-Weaver heterogeneity index (H'), and Sorensen's similarity index (SSI). Additionally, river water samples were taken to determine its main chemical characteristics. The results indicated a statistical difference between sites (α≤0.05), where the most important species, given its dominance, density, and frequency, was Platanus mexicana (IVI=182.71); it was also the most important for its diameter, height, and cover (FVI=300.00). Specific richness (H'=0.54) was found in only six species: Alnus acuminata, Ligustrum japonicum, Parathesis serrulata, Pinus patula, Platanus mexicana, and Quercus rugosa. With regard to SSI, the paired combination of sites 4 (1586 m asl) and 5 (1536 m asl) matched the following species: Alnus acuminata, Ligustrum japonicum, and Platanus mexicana (SSI=1.00). The structure (fragmented) and diversity (very low) of the arboreal plat life of the gallery forest evidence the changes in its composition, without any negative effects on water quality for its exploitation.
Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Extracellular vesicles (EVs) are important mediators of intercellular communication that participate in many physiological/pathological processes. As such, EVs have unique properties related to their origin, which can be exploited for drug delivery applications in cell regeneration, immunosuppression, inflammation, cancer treatment or cardioprotection. Moreover, their cell-like membrane organization facilitates uptake and accumulation in specific tissues and organs, which can be exploited to improve selectivity of cargo delivery. The combination of these properties with the inclusion of drugs or imaging agents can significantly improve therapeutic efficacy and selectivity, reduce the undesirable side effects of drugs or permit earlier diagnosis of diseases. In this review, we will describe the natural properties of EVs isolated from different cell sources and discuss strategies that can be applied to increase the efficacy of targeting drugs or other contents to specific locations. The potential risks associated with the use of EVs will also be addressed.
Reproductive functions and genetic architecture of the seminal fluid and sperm proteomes of the mosquito Aedes aegypti

The yellow fever mosquito, Aedes aegypti, transmits several viruses, including dengue, Zika, and chikungunya. Some proposed efforts to control this vector involve manipulating reproduction to suppress wild populations or replacing them with disease-resistant mosquitoes. The design of such strategies requires an intimate knowledge of reproductive processes, yet our basic understanding of reproductive genetics in this vector remains largely incomplete. To accelerate future investigations, we have comprehensively catalogued sperm and seminal fluid proteins (SFPs) transferred to females in the ejaculate using tandem mass spectrometry. By excluding female-derived proteins using an isotopic labelling approach, we identified 870 sperm proteins and 280 seminal fluid proteins. Functional composition analysis revealed parallels with known aspects of sperm biology and SFP function in other insects. To corroborate our proteome characterization, we also generated transcriptomes for testes and the male accessory glands—the primary contributors to Ae. aegypti sperm and seminal fluid, respectively. Differential gene expression of accessory glands from virgin and mated males suggests that protein translation is upregulated post-mating. Several SFP transcripts were also modulated after mating, but >90% remained unchanged. Finally, a significant enrichment of SFPs was observed on chromosome 1, which harbors the male sex determining locus in this species. Our study provides a comprehensive proteomic and transcriptomic characterization of ejaculate production and composition and thus provides a foundation for future investigations of Ae. aegypti reproductive biology, from functional analysis of individual proteins to broader examination of reproductive processes.
Combat experiences and post-deployment adjustment

The United States of America has been a nation constantly at war for almost two decades. This has resulted in military families being separated from their service member for significant periods of time due combat deployments, which can potentially have a negative impact on the family system. During deployments, service members can be exposed to various combat experiences, which research has linked to symptoms of posttraumatic stress, depression, and problematic alcohol use that develop post deployment. It is estimated that approximately 20% of soldiers in combat units return home with symptoms of behavioral health problems or develop these symptoms within three to six months following the deployment. Family reintegration can negatively be impacted when service members return home from a combat deployment and/or experience behavioral health concerns. By contrast, research has also indicated that healthy social supports, such as families and friends, can mitigate the development and/or aid the recovery of behavioral health concerns. This study investigates the relationship between combat exposure and marriage quality, and their impact on the behavioral health outcomes reported immediately following the deployment and four months post deployment. Additionally, utilizing the lens of the family system theory, the study examines the moderating effect that marriage quality has on the relationship between combat exposure and reported behavioral health symptoms. This study was
Serum micro-RNA Identifies Early Stage Colorectal Cancer in a Multi-Ethnic Population

Objective: Certain microRNAs (miR) have been previously described to be dysregulated in cancers and can be detected in blood samples. Studies examining the utility of miRs for colon cancer screening have primarily been performed in ethnically homogeneous groups of patients, thus the performance of miRs in multiethnic populations is unknown. Methods: Four miRs were selected that were shown to be aberrantly expressed in the blood or stool of patients with colorectal cancer (CRC) of various ethnicities. In this study, the ability of these miRs to discern early stage CRC was determined in a previously untested multiethnic population of 73 CRC cases and 18 controls. Results: The ratios of non-vesicular to extracellular vesicular levels of miR’s -21, -29a, and -92a were statistically and quantitatively related to CRC stage compared to controls. Conclusion: Serum levels of miR-21, miR-29a and miR-92a were able to significantly detect early stage CRC in a multiethnic and previously untested population.
Regulation of branched-chain amino acid metabolism in major metabolic tissues of dairy cows during late pregnancy and early lactation

Branched-chain α-keto acid dehydrogenase (BCKDH) complex catalyzes the irreversible oxidative decarboxylation of branched-chain α-keto acids. This reaction is considered as the rate-limiting step in the overall branchedchain amino acid (BCAA) catabolic pathway in mammals. For characterizing the potential enzymatic involvement of liver, skeletal muscle, adipose tissue (AT), and mammary gland (MG) in BCAA metabolism during early lactation, tissue and blood samples were examined on d 1, 42, and 105 after parturition from 25 primiparous Holstein cows. Serum BCAA profiles were analyzed and the mRNA and protein abundance as well as the activity in the different tissues were assessed for the BCAA catabolic enzymes, partly for the branched-chain aminotransferase and completely for BCKDH. Total BCAA concentration in serum was lowest on d 1 after parturition and increased thereafter to a steady level for the duration of the experiment. Pronounced differences between the tissues were observed at all molecular levels. The mRNA abundance of
RNA-directed DNA Methylation in Arabidopsis

RNA-dirigierte DNS Methylierung (RdDM) ist ein epigenetischer Prozess, der zuerst in Pflanzen aufgeklart wurde, wobei doppelstangige RNA (dsRNA) in 24 nt siRNAs verarbeitet werden, um de novo Methylierung von sowohl symmetrischen als auch asymmetrischen Cytosinen, umgeben von jedweder Sequenz, an der homologen DNA Region zu bewirken. Kapitel I: Im RNA-dirigierenden DNA Methylierungs (RdDM) Pfad fuhren kleine RNA Molekule, die sogenannten siRNAs, Cytosin Methylierung an die passenden Stellen im Genom. An einigen Stellen kann durch die Produktion der sogenannten sekundaren siRNAs, die fur Ihre Biogenese auf Pol IV and RDR2 angewiesen sind, die Ausbreitung der Methylierung uber den ursprunglich modifizierten Bereich hinaus erfolgen. Hier zeigen wir, dass sekundare siRNAs nicht nur in cis an der Stelle wo sie hergestellt werden Methylierung bewirken konnen, sondern auch in trans an ungekoppelten homologen Zielstellen, sofern diese Sequenzen durch Pol II transkribiert werden um eine “nascent“ RNA zu erzeugen. Pol II Transkription scheint die Amplifikation von den siRNAs an der Zielstelle zu unterstutzen, vermutlich durch Erhohung der siRNAs auf Niveaus, die ausreichend sind um RdDM zu induzieren. Nicht-transkribierte Zielstellen, die in der Anwesenheit von in trans wirkenden sekundaren siRNAs unmethyliert verbleiben, konnen trotzdem von reichlichen Mengen von Haarnadel-abgeleiteten siRNAs, die unabhangig von Pol IV und RDR2 sind, methyliert werden. So scheint es, dass die Transkription einer Zielstelle durch Pol II fur die siRNA abhangige DNA Methylierung nicht erforderlich ist, sondern eher fur die Vervielfachung der siRNAs, hochst wahrscheinlich durch ihre bekannte Fahigkeit Pol IV zu rekrutieren. Die Wichtigkeit von Pol II Transkription fur die siRNA Vervielfachung ist vielleicht besonders offensichtlich, wenn der ursprungliche Ausloser, der in unseren Experimenten aus in trans wirkenden sekundaren siRNAs bestand, in geringem Uberschuss vorhanden ist. Kapitel II: DNA Methylierung ist eine epigenetische Modifikation, die in der Stilllegung von Transposons beteiligt ist, um die Integritat des Genoms zu erhalten. In Pflanzen werden Transposons durch CG, CHG, CHH Methylierung modifiziert, verursacht durch kleine interferierende RNA-dirigierter DNA Methylierung (RdDM). Im Gegensatz dazu haben ein Drittel der Protein-kodierenden Gene CG Methylierung, die siRNA unabhangig ist, in ihrer fur Aminosauren kodierenden Sequenz (Gen-Korper). Die Funktion dieser Gen-Korper Methylierung bleibt unbekannt. Hier berichten wir uber atypische, fur Transposon ahnliche DNA Methylierung im Gen Korper von einigen Genen die reich an Cystein sind (CRPs-Cystein reiche Peptide). Wenigstens ein Teil dieser Methylierung wird von RdDM verursacht. Die Transposon-ahnliche Gen Korper Methylierung ist wahrscheinlich mit der Stilllegung der CRP Gene in sporophytischen Geweben verbunden, da die Methylierung in Synergid Zellen, in denen die CRP Gene spezifisch exprimiert werden, verloren geht. Das Transposon-ahnliche Methylierungs-Muster einiger CRP Gene konnte auf einen Retrogen Ursprung hinweisen.
Epidemiological dynamics of bacteriocin competition and antibiotic resistance

Bacteriocins, toxic peptides involved in the competition between bacterial strains, are extremely diverse. Previous work on bacteriocin dynamics has highlighted the role of non-transitive ‘rock-paper-scissors’ competition in maintaining the coexistence of different bacteriocin profiles. The focus to date has primarily been on bacteriocin interactions at the within-host scale. Yet, in species such as Streptococcus pneumoniae with relatively short periods of colonisation and limited within-host diversity, ecological outcomes are also shaped by processes at the epidemiological (between-host) scale. Here, we first investigate bacteriocin dynamics and diversity in epidemiological models. We find that in these models, bacteriocin diversity is more readily maintained than in within-host models, and with more possible combinations of coexisting bacteriocin profiles. Indeed, maintenance of diversity in epidemiological models does not require rock-paper-scissors dynamics; it can also occur through a competition-colonisation trade-off. Second, we investigate the link between bacteriocin diversity and diversity at antibiotic resistance loci. Previous work has proposed that bacterial duration of colonisation modulates the fitness of antibiotic resistance. Due to their inhibitory effects, bacteriocins are a plausible candidate for playing a role in the duration of colonisation episodes. We extend the epidemiological model of bacteriocin dynamics to incorporate an antibiotic resistance locus and demonstrate that bacteriocin diversity can indeed maintain the coexistence of antibiotic sensitive and resistant strains.
Decodificação de Reticulados via Fatoração QR

A estrutura e as propriedades dos reticulados vem sendo exploradas em diversas areas, dentre elas a telecomunicacoes e, em particular, a teoria da informacao e codificacao. O estudo dos reticulados surgiu a partir do problema de como cobrir o espaco no Rn com esferas de mesmo raio, de forma que quaisquer duas esferas se toquem em apenas um ponto e ocupem o maior espaco possivel, [1]. O objetivo deste trabalho e apresentar uma estrategia de decodificacao para reticulados conhecida como Sphere Decoding que faz uso da fatoracao QR na matriz geradora do reticulado para decodifica-lo utilizando a metrica euclidiana, [2]. [. ]
Tumor in the Pancreatic Head: A Case Report

The Pancreatic adenocarcinoma affects the pancreatic head in 60 to 70% of cases, most cases with cholestasis, increased blood levels of direct bilirubin (a breakdown product of hemoglobin) with the clinic at the moment of the diagnosis [1]. Pancreatic cancer is usually diagnosed in subjects older than 40 years-old and its prevalence peaks at the age of 70 years-old. Surgical resection represents the only therapeutic alternative with a better chance of cure [2]. Pancreatic cancer has a high mortality rate due to late diagnosis and aggressive behavior. The prognosis is poor, with 5-year survival occurring in less than 5% of cases. The addition of modern diagnosis methods associated to the improvement of the other methods that already exist has given rise to controversy regarding to the best way of diagnosing and tumor staging. Likewise, the role of surgery in palliation and technical aspects of the located injuries resection are far from reaching consensus on practice [3,4].