Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of neonatal peripheral tissue injury on pain-related behaviors in adult rats

Objective To observe the effects of peripheraltissueinjury in the developmental stage of newborn rats on pain-related behaviors in adult rats. Methods SD rats 1,4,7,14,21 and 28days after birth were selected in thepresent study(4litters at each time point and 10 rats per litter). Each litter of rats was randomly divided intoinjury group(receiving subcutaneous injection of 20μl bee venom)and control group(receiving subcutaneous injection of 20μl normal saline), with20 in each group, and then raised for 2 months to adulthood. The baseline pain threshold was observed by measuring spontaneous paw flinching reflex,paw withdrawal thermal latency(PWTL)and paw withdrawal mechanical threshold(PWMT), then 50μl 0.4% bee venom was subcutaneously injected to each rat, and the changesinpa in reaction and pain threshold were determined. Results The baseline thermal pain threshold in adult rats receiving bee venom or normal saline at different time points after birth was similar,but baseline mechanical pain threshold in adult rats receiving bee venom at1,4,7and14 days after birth was decreased significantly compared with the adult rats receiving normal saline at corresponding time points(P 0.05). Mechanical hyperalgesia was not induced in rats injected with bee venom but induced in adult ratsinjected with normal saline4-21days after birth.Injection of bee venom 21 and 28 days after birth could obviously enhance the bee venom-induced hyperalgesiain adult rats compared with control group(P<0.01). Conclusions Bee venom stimuli at different time points after birth could affect the baseline PWMT and mechanical pain hypersensitivityin adult rats but not the baseline PWTL and thermal pain hypersensitivity. The 21st day maybe a key time point of nervous system development in rats.
Snap-dragging

We are interested in the problem of making precise line drawings using interactive computer graphics. In precise line drawings, specific relationships are expected to hold between points and lines. In published interactive drawing systems, precise relationships have been achieved by using rectangular grids or by solving simultaneous equations (constraints). The availability of fast display hardware and plentiful computational power suggest that we should take another look at the ruler and compass techniques traditionally used by draftsmen. Snap-dragging uses the ruler and compass metaphor to help the user place his next point with precision, and uses heuristics to automatically place guiding lines and circles that are likely to help the user construct each shape. Snap-dragging also provides translation, rotation, and scaling operations that take advantage of the precision placement capability. We show that snap-dragging compares favorably in power and ease of use with grid or constraint techniques.
2-Bromo-1-[1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]ethanone

The asymmetric unit of the title compound, C11H9Br2N3O, contains two crystallographically independent molecules with similar geometries; the Br—C—C=O torsion angles are 1.2 (4) and −2.8 (4)°, and the benzene and triazole rings are inclined o one another by 51.90 (16) and 51.88 (16)°. The two molecules are related by a pseudo-screw 21 axis directed along [100]. In the crystal, molecules are linked into a three-dimensional network by weak C—H⋯O and C—H⋯N hydrogen bonds and secondary Br⋯Br [3.5991 (8) and 3.6503 (9) Å] interactions.
Digital photography in Dentistry: Techniques and clinical importance FOTOGRAFÍA DIGITAL EN ODONTOLOGÍA: TÉCNICAS Y LA IMPORTANCIA CLÍNICA

More than any other health specialty, Dentistry has benefited from the trends and advances in digital photography, and a well designed protocol of dental photography may be a great contribution for the orthodontic practice. Digital records may be used for several purposes, including patient records, treatment evaluation, patient counseling, didactic and medico-legal uses, as well as to present the quality of procedures for marketing purposes. A good for dental photography protocol may greatly enhance the dental practice. The aim of this article is to describe scientific and technical information in detail to provide a guide for dentists who wish to use photography more effectively. This article also addresses some relevant questions for the selection and applicable settings of semiprofessional and compact digital camera systems to enhance the achievement of good-quality and well-focused photographs.
Gender differences in cardiovascular disease : an epidemiologic study of endocrine factors

textabstractThe initial interst in coronary- heart disease research in the 1950s centered primarily on men because of its emergence as a major cause of morbidity and mortality in men around middle age. In women, the incidence of coronary heart disease is low at younger age and increases after middle age, though the occurrence remains lower in women than in men at all ages. The fact that cardiovascular disease is the major cause of morbidity and mortality in women has been recognized already for many years and the last decade much effort has been put in describing and studying cardiovascular disease in women. Despite the research that has been carried out on the differences in cardiovascular disease between the sexes, the gender gap in coronary- heart disease occurrence is not completely understood until now. 1 The work presented in this thesis aims at gaining insight into gender specific issues of cardiovascular disease and the cause of the rising incidence of cardiovascular disease in women after middle age by studying putative endocrine and metabolic risk factors. Data from various population-based studies were used to study these issues. In chapter 2, studies on classical cardiovascular disease risk factors attenuating the female advantage with regard to cardiovascular disease occurrence are presented. Chapter 3 contains studies on sex specific determinants of cardiovascular disease with a focus on sex steroids. In chapter 4, studies on alternative endocrine cardiovascular disease risk factors in postmenopausal women are described. In chapter 5, the results described in this thesis are placed in a broader context, some methodological considerations are discussed, and views on further research regarding gender specific issues of cardiovascular disease are put forward.
1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}ethanone

In the title compound, C19H20F2N2O, the six-membered piperazine group adopts a slightly distorted chair conformation. The dihedral angle between the mean planes of the two benzene rings is 73.4 (6)°. The mean plane of the ethanone group is twisted from the mean planes of the two benzene rings by 66.7 (8) and 86.2 (6)°. In the crystal, C—H⋯O and C—H⋯F interactions link the molecules, forming a three-dimensional structure.
2-Isopropyl-6-methylpyrimidin-4(3H)-one

The molecular structure of the title compound, C8H12N2O, indicates that 2-isopropyl-6-methylpyrimidin-4-ol (the enol–form) undergoes an enol-to-keto tautomerism during the crystallization process. The pyrimidin-4(3H)-one group is essentially planar, with a maximum deviation of 0.081 (1) Å for the O atom. In the crystal structure, symmetry-related molecules are linked into centrosymmetic dimers via pairs of intermolecular N—H⋯O hydrogen bonds, generating R 2 2(8) rings. These dimers are stacked along the a axis.
Sim-Suite

In this paper, we describe the installation Sim-Suite which engages members of the public through interactive experiences based on everyday play strategies and basic full-body human movement. The underlying concept of Sim-Suite explores a recombinant approach to cultural understandings in regards to the social practice of play and embodiment. Our approach deploys digital technologies to facilitate human-to-human tangible interaction using common materials and objects. In this context, the experience of the physical world is expanded and reconfigured together with the transient virtual space of play and digital media.
Smart-Web

The problems associated with the management of Internet sites that require dynamic content or constant changes has led to the production of the article. http://www.smart-city.com. au is a local government Internet site which has made use of Smart-Web to alleviate the bottleneck that is encountered at the Web master when highly dynamic Web content most be altered. It was found that such content could be much move easily handled if the owners of the data had access to change both the data and the structure of the site. The Smart-Web menuing system has been in use since September 1999 and can be viewed at http://www.smart-city.com. au.
Boc-AzAla-Ala-OMe

The title compound (systematic name: tert-butyl 3-{[1-(methoxycarbonyl)ethyl]aminocarbonyl}-3-methylcarbazate), C11H21N3O5, is a precursor for the study of a new class of foldamer based on aza/α-dipeptide oligomerization [Abbas et al. (2009 ▶). Tetrahedron Lett. 50, 4158–4160]. The asymmetric unit consists of one molecule in an extended conformation which is stabilized by intermolecular N—H⋯O and C—H⋯O hydrogen bonding.
Optimal methods for coordinated en-route Web caching

Web caching is an important technology for improving the scalability of web services. This dissertation investigates some key problems for coordinated en-route web caching, such as (multimedia) object caching, (transcoding) proxy placement, cache replacement. The main contributions of this dissertation are outlined as follows: • We address the problem of coordinated en-route web object caching for tree networks (i.e., determining the locations where a copy of the same object should be cached in a network such that the specified objectives are achieved). A dynamic programming-based optimal solution and its analysis are presented. We also extend this solution to solve the problem of coordinated en-route object caching for autonomous systems and the problem of proxy placement for coordinated en-route web caching in tree networks and autonomous systems (i.e., determining the locations where a cache/proxy should be placed in a network such that the specified objectives are achieved). Extensive simulation experiments are conducted to evaluate our proposed solutions over a wide range of performance metrics in comparison with existing solutions proposed in the literature. • We address the problem of coordinated en-route multimedia object caching for transcoding proxies for linear and tree networks (i.e., deciding the locations where an exact version of the same multimedia object should be stored in a network so that the specified objective is arrived). Dynamic programming-based optimal solutions and their analysis are also presented. We further extend these solutions to solve the problem of proxy placement for coordinated en-route transcoding proxy caching (i.e., deciding the locations where a transcoding proxy should be placed in a network so that the specified objective is arrived). We compare the performance of our solutions with other solutions over various performance metrics through extensive simulation experiments. The simulation results show that our solutions outperform existing solutions proposed in the literature. • We address the problem of multimedia object placement for transparent data replication, i.e., choosing a specific version of the same multimedia object to be cached at each node in a network such that the specified objectives are reached. The performance objective is to minimize the total access cost by considering both transmission cost and transcoding cost. We present optimal solutions for different cases for this problem. The performance of the proposed solutions is evaluated with a set of carefully designed simulation experiments for various performance metrics over a wide range of system parameters. The simulation results show that our solution consistently outperforms existing solutions in terms of all the performance metrics considered. • We address the problem of cache replacement for transcoding proxy caching (i.e., selecting the objects that should be removed from the cache to accommodate a new
(2E)-2-Benzylidene-5,6-dimethoxyindan-1-one

The molecular structure of the title compound, C18H16O3, is roughly planar; the maximum deviation of the indanone ring system is 0.027 (1) Å and it makes a dihedral angle of 2.69 (3)° with the phenyl ring. The torsion angles between the two methoxy groups and the indanone ring are −14.67 (11) and −1.11 (12)°. In the crystal, molecules are connected into a ribbon along the a axis via weak intermolecular C—H⋯O hydrogen bonds. Weak intermolecular C—H⋯π and π–π [centroid–centroid distance = 3.7086 (6) Å] interactions are also observed.
4-[4-(4-Nitrophenyldiazenyl)phenyl]hexanenitrile

In the molecule of the title compound, C18H18N4O2, the aromatic rings are oriented at a dihedral angle of 3.72 (3)°. In the crystal structure, intermolecular C—H⋯O hydrogen bonds link the molecules into centrosymmetric dimers. There are also C—H⋯π interactions.
(E)-1-[2-(Methylsulfanyl)phenyl]-2-({(E)-2-[2-(methylsulfanyl)phenyl]hydrazinylidene}(nitro)methyl)diazene

In the title compound, C15H15N5O2S2, the phenyl rings make dihedral angles of 4.03 (4) and 9.77 (5)° with the plane defined by the central N—N—C—N—N atoms (r.m.s. deviation = 0.010 Å). The C—S—C—C torsion angles of the methylsulfanyl groups with their respective phenyl rings are −7.47 (13) and −72.07 (13)°. The shortest centroid–centroid distance of 3.707 Å occurs between the two π-systems N—N—C—N—N and the benzene ring in the diazene 1-position. The H atom bound to the N atom is involved in intramolecular N—H⋯N and N—H⋯S contacts, while the nitro O atoms are involved in intermolecular C—H⋯O contacts.
2-Amino-4-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile

In the title compound, C10H12N2S, the thiophene ring is essentially planar (r.m.s. deviation = 0.0290 Å). The two C atoms of the cyclohexene ring (at positions 6 and 7) are disordered over two sets of sites in a 0.810 (5):0.190 (5) ratio. The cyclohexene rings in both the major and minor occupancy conformers adopt a half-chair conformation. In the crystal, there are two types of N—H⋯N interaction. One of these results in centrosymmetric head-to-head dimers corresponding to an R 2 2(12) graph-set motif and the other forms a 20-membered macrocyclic ring involving six molecules.
Cardiovascular protection: a breakthrough for high-risk patients

Blockade of the renin–angiotensin system (RAS) with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (ARBs) has been shown to reduce cardiovascular mortality and morbidity in various patient populations. The recent ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) and Telmisartan Randomized AssessmeNt Study in aCE iNtolerant subjects with cardiovascular Disease (TRANSCEND) studies with the ARB telmisartan, the largest outcome trial programme with an ARB, have extended this evidence base in the broadest cross section of cardiovascular high-risk patients, and provided important new insights into the benefits of RAS blockade. ONTARGET and TRANSCEND recruited patients who were at high risk of vascular events. These patients, who did not have established heart failure and had well controlled blood pressure, had not previously been studied in clinical trials with ARBs. Telmisartan provided cardiovascular protection similar to ramipril but was better tolerated. These studies add to the growing evidence that the effects of RAS inhibitors are not solely dependent on blood pressure reduction. Angiotensin II exerts diverse pro-atherosclerotic effects, and hence blockade of the RAS may directly inhibit the development and progression of atherosclerosis. Finally, together with other smaller outcomes studies, ONTARGET and TRANSCEND provide useful insights into the relative importance of hypertension and other risk factors at different stages of the ‘cardiovascular continuum’. The evidence suggests that high blood pressure has a major impact on cardiovascular risk in the early stages of the continuum, whereas other risk factors like RAS activation become progressively important in later stages.
(E)-6-Chloro-2-(furan-2-ylmethylidene)-2,3,4,9-tetrahydro-1H-carbazol-1-one

In the title compound, C17H12ClNO2, the carbazole unit is nearly planar [maximum deviation = 0.052 (1) Å]. The pyrrole ring makes dihedral angles of 1.92 (8) and 4.71 (11)° with the benzene and furan rings, respectively. Intermolecular N—H⋯O hydrogen bonds form R 2 2(10) rings in the crystal structure.
Prevalence, public health aspects and prevention of diabetes

Globally, diabetes is one of the most common non‐communicable diseases (NCD), affecting an estimated 371 million people (8.3% of the adult population) worldwide in 2012 [1]. Type 2 diabetes accounts for 85–90% of global diabetes, and conservative estimates by the International Diabetes Federation (IDF) predict that diabetes will increase to 776 million by 2035 (9% of the population), and that over 80% of those with diabetes will live in low and middle‐ income countries (LMIC) [2]. The predicted increase in diabetes is largely due to type 2 diabetes and is strongly associated with lifestyle factors, including obesity, physical inactivity and unhealthy diet. The rising incidence of diabetes is not confined to one part of the world and the IDF reports a wide geographic spread. Table 1.1. 1 shows the rising pandemic, split by world region. It illustrates that the diabetes epidemic, although well established in high‐income countries, will be much more prominent as an increasing prob­ lem in LMIC. For example, it is predicted that the number of people with diabetes will double in Africa and the Middle East and North Africa between 2010 and 2030. Approximately 80–90% of those with diag­ nosed diabetes have type 2 diabetes and 10–20% have type 1 diabetes. Different countries exhibit different rates of diabetes with a range from <5% in parts of Africa to >30% amongst adults in Narau. In the United Kingdom (UK), prevalence rates were estimated at 4.26% (2.8 million adults) in 2010 based upon data from the Qualities and Outcomes Framework [3] although this may be an underestimate as a more recent study reported that the prevalence amongst adults in the UK was 3.1 million (7.4%) in 2011 [4]. The global statistics for the prevalence of diabe­ tes refer only to those who have received a diagno­ sis but population‐based studies have reported a high prevalence of undiagnosed diabetes. Globally, approximately 175 million people may be una­ ware of their diabetes [2] and in the UK, for example, it has been estimated that 850 000 people are living with undiagnosed diabetes [5]. There are large differences between countries for the prevalence of undiagnosed diabetes, with rates of 90% reported in some African countries and much lower rates in high‐income countries. As with diagnosed diabetes, over 80% of people with undiagnosed diabetes live in LMIC.
Correlation of 18F-fluoride PET response to dasatinib in castration-resistant prostate cancer bone metastases with progression-free survival: Preliminary results from ACRIN 6687.

5003 Background: Dasatinib is a SRC kinase inhibitor that decreases bone turnover in men with metastatic castration-resistant prostate cancer (mCRPC). 18F-fluoride PET was used to evaluate differential response between normal and tumor bone to dasatinib. Methods: Patients with bone mCRPC underwent dynamic 18F-flouride PET imaging prior to and 12 weeks after dasatinib treatment. Up to 5 bone metastases with matching normal bone regions were selected for analysis by SUVmax, Ki, K1and Patlak flux. Their pre-treatment values and change from pre-treatment to post-treatment values were evaluated via generalized estimating equations to predict skeletal-related events (SRE) and via Cox proportional hazards modeling to predict progression-free survival (PFS) with Prostate Cancer Working Group 2 criteria, overall survival and time to SRE. Results: Eighteen patients treated with dasatinib underwent baseline 18F-flouride PET imaging; 12 had follow-up scans allowing assessment of changes due to therapy. Median age for.
3-[1-(4-Isobutylphenyl)ethyl]-1H-1,2,4-triazole-5(4H)-thione

In the title compound, C14H19N3S, the dihedral angle between the mean planes of the five- and six-membered rings is 74.69 (4)°. Pairs of intermolecular N—H⋯S interactions link neighbouring molecules into dimers with R 2 2(8) ring motifs. These dimers are then linked together by the same type of interactions into an infinite one-dimensional chain along the b axis.
Decreasing inpatient falls: A retrospective analysis with clinical nurse specialist-led interventions

Objective: To identify and analyze associations between characteristics and factors collected on the ‘Post Fall Huddle/Event Report’ form used by Nursing and Risk Management for all inpatient falls. Inpatient falls were defined as any hospitalized patient that had a fall event during their stay. Methods and materials: All inpatient falls, 17 years and older, were included within a six month period for a sample size of 182. SPSS was used for analyses to identify associative predictors. Results: When examining the number of inpatient falls post implementation of the form, the average annual number of inpatient falls decreased by 50%. Several strategies implemented by Clinical Nurse Specialists to be continued include in-depth review of circumstances surrounding the fall; education of staff for consistency in the fall protocol; and reinforcement of purposeful hourly rounding. Conclusions: Suggested associations with injury or increased length of stay included patients with elimination problems, on antihypertensive medications, a higher patient census at the time of the fall on the unit, and any other medication changes. Further revisions continue to increase the objectivity on the’ Post Fall Huddle/Event Report’ form.
GRADO EN ENFERMERÍA Curso académico 2014 - 2015

Introduction: The existence of bedsores has increased in last years, being the 5% of total sanitary costs. There is a strong connection between nutrition and healing process of bedsores. In this situations human body needs extra energy to remain healthy, for this reason, arginine suplements could be a solution to suply the lack of this nutrients because of his power to speed up the healing process. Objectives: The main purpose of this proyect is to measure how an arginine supplements can help into the healing process of bedsores. Furthermore, analyse if carrying out this kind of actions is worth according to economic terms. Last but not least, it would be desirable came to a conclusion about the effective of administration arginine supplements by using a meta-analysis tool. Material and methods: It was used a strategy based on the formulation of a PICO question and some key words which was combined with boolean operators to look for results in different databases. After that, it was thought several inclusion and exclusion criteria to select the most meaningful articles, then proceeded to carry out a critical reading of them. Discussion and results: Finally, a group of 11 articles were chosen as a representative cross – section to be part of this research project. Four of them have played a important role in the meta-analysis. It was considered several aspects to decide the suitability of administrate arginine. For instance, bedsore´s reduction area, time to get a complete cicatrization and cost – effectiveness relation. In order to give more credibility to this research, it has been carried out a meta-analysis over a bedsores measurement variable, PUSH score. It is needed more clinical trial with a higher number of cross – sections and more time in interventions. Conclusions: The attention protocol in patients with bedsores has to be modified, including arginine supplements in their diet to get a meaningful improve in the quality of nursing cares.