Miracle-dz/UniFAR-FTUs huggingface dataset:
Epidemiology of Heligmosomoides polygyrus in mice: experiments on natural transmission

SUMMARY An experimental system is described for the study of the community dynamics of helminth–host populations, using Heligmosomoides polygyrus in the laboratory mouse. The results of a preliminary experiment using closed populations of 50 mice revealed that coexistence of host and parasite occurs for at least 4 months in the absence of immigration, with the generation of epidemiological patterns similar to those observed in the real world. In well-nourished mice the prevalence and intensity of infection initially increased with time and then declined, probably as a result of acquired immunity. The prevalence and intensity of infection increased less rapidly among hosts fed on a low protein diet, but continued to rise over the entire duration of the experiment. This continued rise is interpreted as evidence of a negative effect of protein malnutrition on host immunocompetence. The frequency distributions of parasite numbers/host were over-dispersed in each mouse population. No density dependence in parasite fecundity was detected. Aspiculuris tetraptera was also found to be present in the mouse populations. This parasite was not transmitted between mice fed on a high protein diet, but rose to a prevalence of 80 % in protein malnourished animals. No association between the intensity of A. tetraptera and H. polygyrus could be detected in individual hosts. The results are discussed in terms of the future potential of the system for the investigation of the role of acquired immunity (and its genetic control) in the generation of epidemiological patterns.
Ecology of avian influenza viruses in a changing world

Influenza A virus infections result in ∼500,000 human deaths per year and many more sublethal infections. Wild birds are recognized as the ancestral host of influenza A viruses, and avian viruses have contributed genetic material to most human viruses, including subtypes H5N1 and H1N1. Thus, influenza virus transmission in wild and domestic animals and humans is intimately connected. Here we review how anthropogenic change, including human population growth, land use, climate change, globalization of trade, agricultural intensification, and changes in vaccine technology may alter the evolution and transmission of influenza viruses. Evidence suggests that viral transmission in domestic poultry, spillover to other domestic animals, wild birds and humans, and the potential for subsequent pandemic spread, are all increasing. We highlight four areas in need of research: drivers of viral subtype dynamics; ecological and evolutionary determinants of transmissibility and virulence in birds and humans; the impact of changing land use and climate on hosts, viruses, and transmission; and the impact of influenza viruses on wild bird hosts, including their ability to migrate while shedding virus.
Cross-lingual Candidate Search for Biomedical Concept Normalization

Biomedical concept normalization links concept mentions in texts to a semantically equivalent concept in a biomedical knowledge base. This task is challenging as concepts can have different expressions in natural languages, e.g. paraphrases, which are not necessarily all present in the knowledge base. Concept normalization of non-English biomedical text is even more challenging as non-English resources tend to be much smaller and contain less synonyms. To overcome the limitations of non-English terminologies we propose a cross-lingual candidate search for concept normalization using a character-based neural translation model trained on a multilingual biomedical terminology. Our model is trained with Spanish, French, Dutch and German versions of UMLS. The evaluation of our model is carried out on the French Quaero corpus, showing that it outperforms most teams of CLEF eHealth 2015 and 2016. Additionally, we compare performance to commercial translators on Spanish, French, Dutch and German versions of Mantra. Our model performs similarly well, but is free of charge and can be run locally. This is particularly important for clinical NLP applications as medical documents underlay strict privacy restrictions.
Activation of human dendritic cells by the PorA protein of Neisseria meningitidis

The major porin proteins present in the outer membrane of Neisseria meningitidis, the causative agent of life‐threatening meningitis and septicaemia, are believed to have potent immunostimulatory effects. In this study, the interactions between human monocyte‐derived dendritic cells (mo‐DC) and the PorA porin were investigated, in order to reveal the role of this protein in promoting innate and adaptive immune responses. Recombinant (r)PorA induced mo‐DC maturation, as reflected by reduced receptor‐mediated endocytosis, increased production of the chemokines IL‐8, RANTES, MIP‐1α and MIP‐1β and augmented expression of the surface markers CD40, CD54, CD80, CD86 and major histocompatibility complex class II molecules. However, rPorA induced either low level or no significant secretion of pro‐inflammatory cytokines from mo‐DC. The protein potently augmented the capacity of mo‐DC to activate both allogeneic CD4+ memory T‐cells and CD4+RA+ naïve T‐cells. In addition, rPorA appeared to inhibit the production of IL‐12p70 that follows from the interaction between CD40 on the mo‐DC and CD40‐ligand on T‐cells, thereby directing T‐cell differentiation towards a Th2 type response. These data demonstrate that PorA is involved in DC activation and in influencing the nature of the T‐helper immune response, which are important properties for generating antibody responses required for protective immunity against meningococci and for determining the immuno‐adjuvant effects of this protein.
Efficacy and safety comparison of nabpaclitaxel plus S-1 and gemcitabine plus S-1 as first-line chemotherapy for metastatic pancreatic cancer

Objective To compare efficacy and safety of nabpaclitaxel plus S-1 (AS) with gemcitabine plus S-1 (GS) as first-line treatment for metastatic pancreatic cancer. Methods We conducted a retrospective cohort, single-institution analysis by reviewing medical records of 38 patients who received either AS (nabpaclitaxel 125 mg/m2 on Days 1, 8 and S-1 80 mg/m2 on Days 1 to 14) or GS (gemcitabine 1000 mg/m2 on Days 1, 8 and S-1 80 mg/m2 on Days 1 to 14) chemotherapy. Results AS was associated with a prolonged median time to progression (TTP; 7.1 months, 95% CI, 4.5-9.7 vs. 3.6 months, 95% CI, 1.8-5.4; P value = 0.022) and improved median overall survival (OS; 10.2 months, 95% CI, 9.1-11.3 vs. 6 months, 95% CI, 4.2-7.8; P value <0.001) compared with GS. In cox proportional hazards model, treatment regimen was the only variable to be significantly associated with improvements in both TTP and OS. Subgroup analyses based on HER2 expression showed that AS seemed to have better outcome of OS in HER2 positive patients (HR = 0.168; 95% CI, 0.022-1.27; P value = 0.084). Hematological adverse events were commonly seen in both group (12.5% and 22.7%, GS and AS group, Grade 3 or 4; P value = 0.675) while AS got increased risk of sensory neuropathy (6 of 22 patients in AS, 27.3% vs. 0 of 16 patients in GS, all grade; P value = 0.03). Conclusions AS could be an effective treatment regimen for metastatic pancreatic cancer under surveillance of toxicity.
HW/SW codesign of maximum Lyapunov exponent estimator

The maximum Lyapunov exponent (MLE) of a dynamic system is a quantity that characterizes the degree of separation of two infinitesimally close paths, it gives a measure of the average rate of exponential divergence of nearby orbits. It is known as a general indicator of the presence of chaos in a dynamic system. This quantifier has been applied in diverse fields, such as biomedicine and finance, in many of these applications, the system is inaccessible and also a real-time measurement is required. In this work, Kantz's estimator of the MLE [1] was implemented in a PSoC (Programmable System-on-Chip), Zedboard FPGA, that supports both software and hardware design. This algorithm is calculated over a stream of data already generated, does not need access to the system and presents a high level of immunity to noise. The algorithm requires calculation in parallel, and also sequential development so that the used platform presents optimal characteristics for its implementation.
Controlled tracking in urban terrain: Closing the loop

We investigate the challenging problem of integrating detection, signal processing, target tracking, and adaptive waveform scheduling with lookahead in urban terrain. We propose a closed‐loop active sensing system to address this problem by exploiting three distinct levels of diversity: (1) spatial diversity through the use of coordinated multistatic radars; (2) waveform diversity by adaptively scheduling the transmitted waveform; and (3) motion model diversity by using a bank of parallel filters matched to different motion models. Specifically, at every radar scan, the waveform that yields the minimum trace of the one‐step‐ahead error covariance matrix is transmitted; the received signal goes through a matched‐filter, and curve fitting is used to extract range and range‐rate measurements that feed the LMIPDA‐VSIMM algorithm for data association and filtering. Monte Carlo simulations demonstrate the effectiveness of the proposed system in an urban scenario contaminated by dense and uneven clutter, strong multipath, and limited line‐of‐sight.
Local versus general anaesthesia for carotid endarterectomy.

BACKGROUND Carotid endarterectomy reduces the risk of stroke in people with recently symptomatic, severe carotid artery stenosis. However, there are significant perioperative risks which may be lessened by performing the operation under local rather than general anaesthetic. OBJECTIVES The objective of this review was to assess the effect of endarterectomy under local compared with general anaesthetic. SEARCH STRATEGY We searched the Cochrane Stroke Group trials register, Medline (1966 to 1995), Embase (1980 to 1995), and Index to Scientific and Technical Proceedings (1980 to 1994). We handsearched Annals of Surgery (1981 to 1995), British Journal of Surgery (1985 to 1995), European Journal of Vascular Surgery (1988 to 1995) and World Journal of Surgery (1978 to 1995). Reference lists of articles were searched. SELECTION CRITERIA Randomised trials and non-randomised studies comparing carotid endarterectomy under local versus general anaesthetic. DATA COLLECTION AND ANALYSIS One reviewer selected studies for inclusion and another independently checked the decisions. Two reviewers assessed trial quality and independently extracted the data. MAIN RESULTS Three randomised trials involving 143 patients, and 17 non-randomised studies involving about 5970 patients were included. The methodological quality of the randomised trials was questionable. Two of the non-randomised studies were prospective and 12 reported on a consecutive series of patients. In nine non-randomised studies the number of patients, as opposed to the number of arteries, was unclear. There were insufficient data to enable conclusions to be drawn from the randomised trials. In 15 non-randomised studies, no significant difference was shown between local and general anaesthetic in deaths within 30 days of operation (odds ratio 0.61, 95% confidence interval 0.32 to 1.16). Non-randomised studies showed that local anaesthetic was associated with a significant reduction in the odds of stroke (15 studies), stroke or death (14 studies), myocardial infarction (12 studies), and pulmonary complications (five studies), within 30 days of the operation. Patient and surgeon satisfaction were not reported in any study. REVIEWER'S CONCLUSIONS There is not enough evidence from randomised trials comparing carotid endarterectomy performed under local as opposed to general anaesthetic. Non-randomised studies suggest potential benefits with local anaesthetic. However these studies are likely to be significantly biased.
Immune-mediated inflammatory reactions and tumors as skin side effects of inflammatory bowel disease therapy

Abstract All drugs currently used for treating patients with inflammatory bowel disease (IBD – including Crohn’s disease and ulcerative colitis) have the potential to induce skin lesions ranging from mild eruptions to more serious and widespread clinical presentations. The number of cutaneous adverse reactions due to IBD therapies is progressively increasing and the most frequently involved drugs are thiopurines and biologics like tumor necrosis factor (TNF)-α antagonists. The main drug-induced cutaneous manifestations are non-melanoma skin cancer (NMSC), notably basal cell and squamous cell carcinomas, and viral skin infections for thiopurines and psoriasiform, eczematoid and lichenoid eruptions as well as skin infections and cutaneous lupus erythematosus for biologics. Cutaneous manifestations should be promptly recognized and correctly diagnosed in order to quickly establish an adequate therapy. The main treatment for NMSC is surgical excision whereas the management of immune-mediated inflammatory skin reactions varies from topical therapy for mild presentations to the shift to another drug alone or in combination with corticosteroids for extensive eruptions.
Quality of life of asthmatic children and adolescents: Portuguese translation, adaptation, and validation of the questionnaire “Pediatric Quality of Life (PedsQL) Asthma Module”

ABSTRACT Objective: The objectives of the study were to translate, validate, and verify the psychometric properties of the Portuguese version of the instrument “Pediatric Quality of Life Asthma Module” (PedsQL Asthma) culturally adapted for the Brazilian culture. Methods: After being translated to Portuguese and being culturally adapted, the questionnaire was answered by 200 asthmatic children and adolescents (aged 2–18) as well as the adults responsible for them. Validation required the use of the following instruments: PedsQL Asthma Children (applied to children and adolescents), PedsQL Asthma Parents (applied to adults responsible for children and adolescents), Pediatric Asthma Quality of Life (PAQLQ), Asthma Control Test (ACT) or Childhood Asthma Control Test (C-ACT), as well as socioeconomic and personal information questionnaires. A group of 45 clinically stable children repeated the questionnaires 15–60 days after answering the first questionnaire. Results: Correlations between the scores of PedsQL Children and PedsQL Parents (r = 0.67), PedsQL Children and PAQLQ (r = 0.66), and PedsQL Parents and PAQLQ (r = 0.64) were moderate and significant. Correlations were higher for men (r = 0.72) when analyzing the children's and parents’ answers to PedsQL according to gender. The 5- to 7-year-old age group had the strongest correlations with PAQLQ (r = 0.79). Cronbach's alpha coefficient for PedsQL Children and Parents had values of 0.85 and 0.87, respectively. A high concordance was observed in both tests at different times, with kappa values of 0.89 and 0.87 for PedsQL Children and Parents, respectively. Conclusion: The instrument used in this study was considered valid, consistent, and reproducible and has acceptable psychometric properties for the Brazilian population.
Transmission de la volatilité entre le marché du pétrole et les marchés financiers des pays producteurs.

This paper examines the dynamics of volatility transmission among, the oil market, the U.S financial market and the financial markets of four oil producing countries (Venezuela, Indonesia, Russia and Kuwait). The study uses a trivariate GARCH model with BEKK parameterization. The findings show that U.S financial market affect oil market and all other financial market of studied countries. There is, also, volatility transmission from oil market to all other financial market of oil producing countries. But it seems that the Russian financial market is likely to influence more the oil market. Our results suggest a powerful relation between physical and financial market which can be useful in the construction of assets pricing models in the oil producing countries and in the forecasting of future price and even volatility of black gold.
Economic Dispatch of Power Systems Based on the Modified Particle Swarm Optimization Algorithm

This paper presents a new versatile optimization algorithm called modified particle swarm optimization algorithm (MPSO) for solving the economic dispatch (ED) problem of power systems. Compared with the classical PSO algorithm, several modified operators, such as mutation operator and neighborhood magnifying operator, are employed by MPSO to ensure the algorithm search globally in theory. Based on the stochastic analysis theorem, it is proved that MPSO has global convergence property, the convergence property is independent of the initialization, and a sufficient condition for convergence is presented. This algorithm is used to solve the complicated, nonconvex, nonlinear economic dispatch problems. Several factors such as, valve-point effects of fuel cost functions, transmission capacity constraints, and system stability constraints are considered in the computation models. Numerical results show that the proposed method is feasible and efficient
Systemic lupus erythematosus in three ethnic groups: II. Features predictive of disease activity early in its course. LUMINA Study Group. Lupus in minority populations, nature versus nurture.

OBJECTIVE To determine the factors associated with disease activity in patients with recent-onset (< or =5 years) systemic lupus erythematosus (SLE) who were of Hispanic, African-American, or Caucasian ethnicity. METHODS Incident and prevalent cases of SLE, as defined by the American College of Rheumatology criteria for SLE, among the 3 ethnic groups were identified in Alabama (The University of Alabama at Birmingham) and Texas (The University of Texas-Houston Health Science Center and The University of Texas Medical Branch at Galveston). Variables from the sociodemographic, clinical, immunologic, immunogenetic, behavioral, and psychological domains were obtained using validated instruments. Disease activity was ascertained with the Systemic Lupus Activity Measure (SLAM). Stepwise domain regressions with SLAM score as the dependent variable were performed. Final ethnic-specific and overall regression models were obtained by entering variables that were retained in the domain regressions. RESULTS SLAM scores at study entry were higher in the African Americans (mean +/- SD 12.6 +/- 6.9) and Hispanics (11.0 +/- 6.2) than in the Caucasians (8.5 +/- 3.7) (P < or = 0.001). The final overall regression model (R2 = 28%) for higher SLAM score included the following variables: African-American ethnicity, lack of private health insurance, abrupt disease onset, presence of anti-Ro antibodies, absence of HLA-DRB1*0301, higher levels of helplessness, and abnormal illness-related behaviors. CONCLUSION Socioeconomic, immunologic, immunogenetic, behavioral, and psychological variables were all predictive of disease activity early in the course of SLE, irrespective of ethnic group. However, there remain ethnic group differences in disease activity that were not explained by these factors.
EXAMINING SELECTION ON THE MULTIVARIATE PHENOTYPE: PLANT RESISTANCE TO HERBIVORES

Cost–benefit theory posits that stabilizing selection, produced by a trade‐off between associated costs and benefits, often maintains phenotypic traits at intermediate equilibrium values. Measurement of selection on one type of trait, resistance to herbivory, should provide evidence to test this prediction. However, most plants host more than one species of herbivore, and resistance to various herbivores may be phenotypically correlated. Consequently, selection must be measured on a multivariate phenotype, which may produce a very complex selection gradient. Canonical analysis of the matrix of quadratic coefficients of the phenotypic selection gradient is presented as a method to simplify the interpretation of the estimated multidimensional adaptive surface. Because this analytical method finds the canonical axes of second‐order effects on the selection surface, it shows where nonlinear, and possibly stabilizing, selection is strongest. The resulting index traits may generate hypotheses regarding underlying resistance traits to which more than one type of herbivore responds.
The Story of Summer Visions: The Creation of a New Public in a Community-Engaged Youth Media Program

Over the course of the last two decades, youth media programs have become increasingly popular as models for community-engaged digital storytelling projects. This narrative re ection is based on the author’s experience as the creative mentor and story editor within a nationally recognized youth-run media production program. Drawing on Arendt’s (1954) thinking on the educative project and on Poyntz’s (2009) argument that holds "agonistic struggle" over creative expression within a community of youth engagement is critical to developing a shared sense of the world. This narrative re ects on the collective work of story creation within a community-engaged media art practice as a vehicle for developing capacity to hold pluralistic points of view, perspective, and voice essential for the sustainment of democratic movements.
Insufficient Economic Convergence in the World Economy: How Do Economists Explain Why Too Many Countries Do Not Catch-up?

This essay reviews different economic perspectives on the development of productivity and living standards in developing countries. It shows that neoclassical approaches to the problem of economic convergence fail to provide a satisfactory explanation of why economic convergence does not take place. In doing so, it reviews seven heterodox arguments on why developing countries do not converge. The article argues that the lack of economic convergence is a result of market forces which lead to the reproduction of underdevelopment. Therefore, comprehensive state interventions are needed to overcome underdevelopment. The article discusses different alternative policies which are needed to trigger development, thus countering the perspectives of neoliberal economists and the Washington Consensus.
Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64

Exosomes are small membrane vesicles secreted into the extracellular compartment by exocytosis. The unique composition of exosomes can be transported to other cells which allow cells to exert biological functions at distant sites. However, in lung cancer, the regulation of exosome secretion was poorly understood. In this study, we employed human lung adenocarcinoma A549 cells to determine the exosome secretion and involved regulation mechanism. We found that Rab27A was expressed in A549 cells and the reduction of Rab27A by Rab27A‐specific shRNA could significantly decrease the secretion of exosome by A549 cells. EPI64, a candidate GAP that is specific for Rab27, was also detected in A549 cells. By pull‐down assay, we found that EPI64 participated in the exosome secretion of A549 cells by acting as a specific GAP for Rab27A, not Rab27B. Overexpression of EPI64 enhanced exosome secretion. Taken together, in A549 cells, EPI64 could regulate the exosome secretion by functioning as a GAP specific for Rab27A.