Miracle-dz/UniFAR-FTUs huggingface dataset:
Phenobarbitone, neonatal seizures, and video-EEG

Aims: To evaluate the effectiveness of phenobarbitone as an anticonvulsant in neonates. Methods: An observational study using video-EEG telemetry. Video-EEG was obtained before treatment was started, for an hour after treatment was given, two hours after treatment was given, and again between 12 and 24 hours after treatment was given. Patients were recruited from all babies who required phenobarbitone (20–40 mg/kg intravenously over 20 minutes) for suspected clinical seizures and had EEG monitoring one hour before and up to 24 hours after the initial dose. An EEG seizure discharge was defined as a sudden repetitive stereotyped discharge lasting for at least 10 seconds. Neonatal status epilepticus was defined as continuous seizure activity for at least 30 minutes. Seizures were categorised as EEG seizure discharges only (electrographic), or as EEG seizure discharges with accompanying clinical manifestations (electroclinical). Surviving babies were assessed at one year using the Griffiths neurodevelopmental score. Results: Fourteen babies were studied. Four responded to phenobarbitone; these had normal or moderately abnormal EEG background abnormalities and outcome was good. In the other 10 babies electrographic seizures increased after treatment, whereas electroclinical seizures reduced. Three babies were treated with second line anticonvulsants, of whom two responded. One of these had a normal neurodevelopmental score at one year, but the outcome for the remainder of the whole group was poor. Conclusion: Phenobarbitone is often ineffective as a first line anticonvulsant in neonates with seizures in whom the background EEG is significantly abnormal.
Dreams of Mice

Dreams of Mice explores a changed understanding of sleep brought about by networked technologies. A contemporary world of instant messaging and 24/7 connectivity encourages us to remain permanently available. Using computer modeling, recorded neurological data and game engine technology, boredomresearch http://www.boredomresearch. net ask if we can afford to disconnect; questioning the importance of the non-productive third of our lives we spend asleep. Brain activity during sleep reveals that far from downtime, sleep is complex and beautiful. Developed from research exploring the interaction between environmental factors effecting sleep and human neurological disorders Dreams of Mice considers the increased control, management and disruption of sleep behaviours. Collaborating with a neuroscientist at the University of Oxford, capturing and recording the dreams of laboratory mice, boredomresearch have revealed the intriguing beauty of slumber in a real-time artwork driven by the firing neurons of dreaming mice (see Fig.1). When we go to sleep we disconnect from our social networks and perpetual status updates, entering the last remaining sanctuary from the demands of a permanently connected and networked society. But is the space of dreams at risk from the relentless encroachment of connective technologies?
Remote ischemic preconditioning immediately before percutaneous coronary intervention does not impact myocardial necrosis, inflammatory response, and circulating endothelial progenitor cell counts: A single center randomized sham controlled trial

Aims: Percutaneous coronary intervention (PCI) is frequently accompanied by myocardial injury. The present study was performed to determine whether remote ischemic preconditioning (IP) induces cardioprotection during PCI. Methods: We enrolled 95 patients requiring nonemergency PCI for stable disease or unstable angina into this prospective clinical trial. Patients were randomized to either remote IP (induced by three 3‐min cycles of blood pressure cuff inflations to 200 mm Hg around the upper arm, followed by 3‐min of reperfusion n = 47) or sham control (n = 48) immediately preceding PCI. The primary outcome measure was the frequency of post‐PCI myonecrosis, defined as a peak postprocedural cTnT T ≥0.03 ng/dL. Secondary outcome measures were the change in plasma high‐sensitivity C‐reactive protein (hsCRP) levels following PCI and in endothelial progenitor cells (EPC) counts following IP. Results: There was no difference in the primary endpoint of the frequency of PCI related myonecrosis which occurred in 22 (47%) and 19 (40%) patients in the remote IP and control groups, respectively, P = 0.42. There was significant increase in hsCRP post‐PCI in both groups (P < 0.001), but there was no difference between the groups (median %change in hsCRP 46% vs. 54%, P = 0.73). There was no significant change in circulating early (CD34 −/CD133+/KDR+), intermediate (CD34+/CD133+/KDR+), or late (CD34+/CD133−/KDR+) EPC in the two groups immediately following IP. The composite rate of death, myocardial infarction, and target lesion revascularization at 1 year was 14.1% versus 13.7% (P = 0.90). Conclusions: Our study indicates that remote IP immediately before PCI does not induce cardioprotection in low to moderate risk patients. © 2012 Wiley Periodicals, Inc.
El nuevo regionalismo: causas y consecuencias

En este articulo abordamos tres temas en lo que respecta al "nuevo regionalismo': En primer lugar, la consabida analogia que hace referencia al "spaghetti bowl" de los acuerdos de integracion economica (AJEs) quizas deberia reemplazarse por otra analogia de un "mercado" para los AJEs. Analizamos la nocion de "liberalizacion competitiva'; que acuno Fred Bergsten, y sugerimos un marco economico sistematico para examinar, en primer lugar, la liberalizacion competitiva en un contexto estatico y a largo plazo. Abordamos los criterios economicos que podrian explicar de manera empirica las selecciones de los AJE por parte de los gobiernos en un equilibrio economico a largo plazo. En segundo lugar, las pruebas empiricas suelen mostrar los efectos poco significativos -en algunos casos negativos- que los AJEs producen en el comercio. Comentamos las razones por las que las medidas a posteriori de los efectos (de tratamiento) de los AJEs sobre el comercio parecen ser tan poco trascendentes. En tercer lugar, abordamos la liberalizacion competitiva dentro de un contexto dinamico. Tras examinar las pruebas sobre los factores determinantes a largo plazo de la seleccion de los AJEs por parte de los gobiernos, analizamos la manera en que podria conceptualizarse el proceso por el cual los gobiernos seleccionan los AJEs a traves del tiempo, es decir, el crecimiento del regionalismo.
The Political Representation of the Poor: A Research Note Using CSES Data

Studies of the public opinion-policy link argue that policy changes are representative when they reflect aggregate-level changes in public opinion. The opinions of most citizens, however, do not change very much over time. As result, government policy may reflect the changing interests of only a small subset of attentive, informed, and articulate voters. Who are these voters? Where do the poorest citizens of contemporary democracies fit in? Under what conditions are elected officials likely to be more or less responsive to the preferences of poor voters? What are the distributional consequences of partisan and electoral incentives to be more or less responsive to the poor? I address these questions in a larger, broadly comparative study of the political representation of the poor. Here, I focus on the question, “How well are the interests of the poor represented in contemporary democratic governments? ” and develop a simple model of representation that will serve as a way to evaluate patterns of representation. The parameters of this model are estimated using Comparative Study of Electoral Systems data.
Polycystic kidney disease: from the bedside to the gene and back

Collated in this highly personal commentary are the most important research findings of the past 10 years that deal primarily with the renal manifestations of inherited polycystic kidney diseases. Progress in understanding these complex disorders has followed two major concurrent and convergent lines of investigation: genes and genetic mechanisms, and pathogenesis and progression. The field has moved from descriptive pathobiology to the elucidation of molecular mechanisms consequent to genetic and epigenetic events. Doubtless, the favorite works of some who have labored diligently in this field have not been fully exalted, and for this I apologize. Were I the editor, this entire celebratory volume would be used to extol the thrilling growth of knowledge during the tenure of this polycystic kidney disease watcher.
Severe hypotension and fetal death due to tocolysis with nifedipine

Sir, We agree that caution should be exercised when administering nifedipine as a tocolytic. There have been other case reports highlighting the risks. We conducted a survey of consultant obstetrician/gynaecologists in the United Kingdom in an attempt to quantify the extent of significant adverse effects with different tocolytics. Seventyeight replies were received. Fifty-three percent of the respondents used nifedipine as their first-line tocolytic and 40% used atosiban. Of these, 17 reported maternal hypotension of sufficient severity to cause fetal compromise necessitating caesarean section with nifedipine, compared with four with ritodrine and two with atosiban. Unfortunately, the survey responses were anonymous so we have been unable to obtain further details of the cases. As nifedipine is unlicensed in pregnancy, albeit recommended as an alternative to atosiban, by the RCOG green top guidelines, any adverse effects are the responsibility of the prescriber. We suggest that there is a need for a national database of these. References
Reverse current simulation in PV array composed of different modules for interchangeability evaluation of thin film PV modules

We examine and quantify the influence of output difference in photovoltaic (PV) modules in a PV array on safety for standardization on interchangeability of PV modules. First, we modeled I-V characteristics of thin film PV module and maximum power point tracking operation of power conditioning system. Based on the experimental data, we verified validity on the modelling. Then, we simulated reverse current occurrence situation when changing a part of modules in an existing PV array with modules with different electric characteristics and clarified the range of rated value of the different module where reverse current did not occur quantitatively.
Unsupervised dimensionality reduction: the challenge of big data visualization

Dimensionality reduction is an unsupervised task that allows high-dimensional data to be processed or visualised in lower-dimensional spaces. This tutorial reviews the basic principles of dimensionality reduc- tion and discusses some of the approaches that were published over the past years from the perspective of their application to big data. The tu- torial ends with a short review of papers about dimensionality reduction in these proceedings, as well as some perspectives for the near future.
Role of MetMAb (OA-5D5) in c-MET active lung malignancies

Introduction: MetMAb (OA-5D5) is a one-armed monoclonal antibody developed to bind to and inhibit c-MET receptor tyrosine kinase. Though only in early clinical testing, this agent holds great promise in diseases thought to be driven by c-MET activation, as evidenced by the Phase II results in NSCLC where a benefit in overall survival was observed in patients with MET-diagnostic-positive disease. Thus far, both alone and in combination with other targeted agents, this drug has been well tolerated and no new significant safety signals have been identified. Areas covered: This review summarizes the structure and function of the c-MET receptor and its ligand hepatic growth factor (HGF), provides an overview of select targeted monotherapies developed to interfere in the MET–HGF signaling pathway, discusses pre-clinical and clinical data surrounding MetMAb, and concludes with an expert opinion regarding this novel agent. Expert opinion: MetMAb has been well tolerated and based on Phase II data testing it, in combination with erlotinib in advanced NSCLC, may have a role in improving survival in patients with disease driven by c-MET activation. However, Phase III validation is underway and the results of these studies will help elucidate which patients will benefit most from this novel agent.
ANTI-DIABETIC ACTIVITY OF GYMNEMA SYLVESTRE LEAF EXTRACT ON ALLOXAN INDUCED DIABETIC RATS

The concerned study reveals the anti-diabetic effect of Gymnema sylvestre in control of blood glucose level in Alloxan induced Diabetic rats. The recent studies shows the active constituent is Gymnemic acid a triterpenoid saponin has significant effects on the intestinal absorption of glucose in to the blood and stimulation of b-cells of pancreas in the production of Insulin. Being a traditional anti diabetic plant in many alternative systems of medicine, the dried aqueous leaf extract of Gymnema sylvestre at the dose of 100, 200, 300 mg/kg was given orally to the alloxan induced diabetic rats for a period of 21 days and the blood glucose levels was sampled every week. The study showed a significant reduction in the blood glucose levels showing the potential of anti-diabetic activity of Gymnema sylvestre.
Antibodies to heat-labile Escherichia coli enterotoxin in Apaches in Whiteriver, Arizona

Antitoxin titers to heat-labile Escherichia coli enterotoxin were measured in Apache children hospitalized with acute diarrhea and in Apaches of different age groups without diarrhea in Whiteriver, Ariz. The study suggests that in this locale, exposure to enterotocigenic E. coli is probably widespread and occurs early in life. Antitoxin titer rises after idarrheal disease associated with enterotocigenic E. coli infection, however, were not regulary found.
Temporal Word Analogies: Identifying Lexical Replacement with Diachronic Word Embeddings

This paper introduces the concept of temporal word analogies: pairs of words which occupy the same semantic space at different points in time. One well-known property of word embeddings is that they are able to effectively model traditional word analogies (“word w_1 is to word w_2 as word w_3 is to word w_4”) through vector addition. Here, I show that temporal word analogies (“word w_1 at time t_\alpha is like word w_2 at time t_\beta”) can effectively be modeled with diachronic word embeddings, provided that the independent embedding spaces from each time period are appropriately transformed into a common vector space. When applied to a diachronic corpus of news articles, this method is able to identify temporal word analogies such as “Ronald Reagan in 1987 is like Bill Clinton in 1997”, or “Walkman in 1987 is like iPod in 2007”.
Anxiety Sensitivity and Smoking Behavior Among Trauma-Exposed Daily Smokers

Anxiety sensitivity (AS), defined as the extent to which individuals believe that anxiety-related sensations have harmful consequences, is associated with smoking processes and poorer clinical outcomes among trauma-exposed smokers. Yet the specific mechanisms underlying this association are unclear. Smoking-specific avoidance and inflexibility is a construct implicated in multiple manifestations of mood regulation that may underlie smoking behavior. The current study examined the explanatory role of smoking-specific avoidance and inflexibility in terms of the relation between AS and indices of smoking behavior among trauma-exposed smokers. The sample consisted of 217 treatment-seeking adult smokers (44% female; M age = 37.8; SD = 13.2; age range: 18-65 years), who were exposed to at least one lifetime Criterion A trauma event (Diagnostic and Statistical Manual of Mental Disorders [4th ed., text rev.; DSM-IV-TR] Criterion A for trauma exposure). Bootstrap analysis (5,000 re-samples) revealed that AS was indirectly related to the (a) number of cigarettes smoked per day, (b) number of years being a daily smoker, (c) number of failed quit attempts, and (d) heaviness of smoking index among trauma-exposed smokers through its relation with smoking-specific avoidance and inflexibility. These findings provide initial evidence suggesting that smoking-specific avoidance and inflexibility may be an important construct in better understanding AS–smoking relations among trauma-exposed smokers. Future work is needed to explore the extent to which smoking-specific avoidance and inflexibility account for relations between AS and other smoking processes (e.g., withdrawal, cessation outcome) in the context of trauma and smoking comorbidity.
The Concept of Endophenotypes in Psychiatric Diseases Meeting the Expectations?

Although the prominent role of genetics in psychiatric diseases has been established in various family, twin and adoption studies over the last decades, the identification of concrete contributing genes has been demanding. The reasons for this are manifold, including inconsistencies in psychiatric classification systems, complexity and heterogeneity of psychiatric disorders, epistatic effects and intervening environmental factors. In recent years interest has focused increasingly on the concept of endophenotypes. Genetic analyses have concentrated on discrete phenotypes supposedly linked to a particular psychiatric disorder by common neurobiological pathways, instead of studying the complex disease itself. Several endophenotypes have been established for psychiatric diseases including electrophysiological abnormalities and alterations in structural and functional brain imaging. Although results seem to be getting more consistent and reliable, several concerns have also emerged with the experience gained on the topic. This review will give an overview of the prospects and limitations related to endophenotypes in psychiatric diseases. We will also summarize essential prerequisites for successful endophenotypes in the future as well as applications for psychiatric diseases which have been envisioned.
Qualité des langages de modélisation et des modèles : vers un catalogue des patrons collaboratifs

La qualite des langages de modelisation et des modeles ainsi que leur evaluation constituent un verrou important pour le concepteur. Par ailleurs, la proliferation de definition des concepts de qualite et le grand nombre des travaux qui apparaissent jour apres jour, neces- sitent la structuration et la mise en commun des savoirs et des savoir-faire de ce domaine. Dans cet article, nous proposons un systeme des patrons collaboratifs qui capitalisent les connais- sances sur la qualite des langages de modelisation et des modeles. Nous introduisons l'outil COpen, un outil de gestion des patrons collaboratifs, que nous avons utilise pour mettre en œuvre notre systeme de patrons.
p53 inhibits the expression of p125 and the methylation of POLD1 gene promoter by downregulating the Sp1-induced DNMT1 activities in breast cancer

p125 is one of four subunits of human DNA polymerases – DNA Pol δ as well as one of p53 target protein encoded by POLD1. However, the function and significance of p125 and the role that p53 plays in regulating p125 expression are not fully understood in breast cancer. Tissue sections of human breast cancer obtained from 70 patients whose median age was 47.6 years (range: 38–69 years) with stage II–III breast cancer were studied with normal breast tissue from the same patients and two human breast cell lines (MCF-7 and MCF-10A). p53 expression levels were reduced, while p125 protein expression was increased in human breast cancer tissues and cell line detected by Western blot and quantitative reverse transcriptase-polymerase chain reaction. The methylation level of the POLD1 gene promoter was greater in breast cancer tissues and cells when compared with normal tissues and cells. In MCF-7 cell model, p53 overexpression caused a decrease in the level of p125 protein, while the methylation level of the p125 gene promoter was also inhibited by p53 overexpression. To further investigate the regulating mechanism of p53 on p125 expression, our study focused on DNA methyltransferase 1 (DNMT1) and transcription factor Sp1. Both DNMT1 and Sp1 protein expression were reduced when p53 was overexpressed in MCF-7 cells. The Sp1 binding site appears to be important for DNMT1 gene transcription; Sp1 and p53 can bind together, which means that DNMT1 gene expression may be downregulated by p53 through binding to Sp1. Because DNMT1 methylation level of the p125 gene promoter can affect p125 gene transcription, we propose that p53 may indirectly regulate p125 gene promoter expression through the control of DNMT1 gene transcription. In conclusion, the data from this preliminary study have shown that p53 inhibits the methylation of p125 gene promoter by downregulating the activities of Sp1 and DNMT1 in breast cancer.
A Comparative Study Between the Capabilities of MySQl Vs. MongoDB as a Back-End for an Online Platform

In this article we present a comparative study between the usage capabilities of MongoDB, a non-relational database, and MySQL’s usage capabilities, a relational database, as a back-end for an online platform. We will also present the advantages of using a non-relational database, namely MongoDB, compared to a relational database, namely MySQL, integrated in an online platform, which allows users to publish different articles, books, magazines and so on, and also gives them the possibility to share online their items with other people. Nowadays, most applications have thousands of users that perform operations simultaneously thus, it takes more than one operation to be executed at a time, to really see the differences between the two databases. This paper aims to highlight the differences between MySQL and MongoDB, integrated in an online platform, when various operations were executed in parallel by many users.
The motivational basis of organizational behavior.

How, and to what extent, do people become involved in an organization and committed to its goals? If an organization is to survive and to function effectively, it must require not one, but several different types of behavior from most of its members, and the motivations for these different types of behavior may also differ. How does a business organization attract the kind of people it needs? How does it hold them? How does it induce both reliable performance and spontaneous innovation an the part of its members? This paper proposes an analytic framework for understanding the complexities of motivational problems in an organization.