Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative study of maximum respiratory pressure in adults from amazonas by different predictive equations

Introduction: The measurement of muscular strength and maximum static pressures, substantially a consecrated and practical method, raise discussions about reference values and predictive equations, taking into account the heterogeneity of the studies. Objectives: Compare predicted values of IPmax and EPmax with the equations of Neder et al., 1999 and Costa et al., 2010 in adult individuals from the state of Amazonas (AM, Brazil). Method: A cross-sectional study in which was evaluated the Maximum Respiratory Pressures (IPmax and EPmax) according to standardization of the Brazilian Society of Pneumology and Tisiology in 210 individuals (68% female and 32% male) and 109 were eutrophic and 101 with overweight. The age of the individuals was 47,8±18,5 years. For comparative statistical analysis between the values obtained and predicted by the equations was performed the Anova One Way - Software SigmaStat 3.5 test. Results: The comparison of the values obtained with those predicted revealed that the Neder et al underestimated the IPmax in both genders (P <0,001) and overestimated the EPmax in males (P <0,001). While the equation of Costa et al overestimated the IPmax and EPmax in males (P <0,001) underestimated the IPmax in females (P<0,001). Conclusion: The results evidenced divergences in the predictive quality of the equations used, especially for IPmax, which suggests the low specificity of it in the population evaluated.
Radioimmunoassay for Type I Procollagen in Growth Hormone-deficient Children before and during Treatment with Growth Hormone

Type I procollagen concentrations were mea- sured by radioimmunoassay in sera from 14 growth hor- mone-deficient children before and during 12 months of treatment with human growth hormone. Basal procollagen levels were lower than those of control children and com- parable to those of normal adults. With treatment, the mean procollagen level increased into the range of the control children and was significantly greater than the baseline level at 1, 2, 3*, and 12 months (p < 0.01; *p < 0.05). Although there was no significant statistical corre-
Evaluation o f t he Clinical E fficacy o f B enazepril in the T reatment of Chronic Renal I nsufficiency in Cats

Background: Chronic renal insufficiency (CRI) is a common disease in cats. Angiotensin-converting enzyme inhibitors (ACEI) have beneficial effects in humans with CRI by reducing the loss of protein in the urine and increasing life expectancy. Hypothesis: The ACEI benazepril has beneficial effects on survival, clinical variables, or both as compared with placebo in cats with CRI. Animals: 61 cats with naturally occurring CRI. Methods: The cats were enrolled into a prospective, randomized, double-blind, placebo-controlled clinical trial. Cats received placebo or 0.5–1 mg/kg benazepril once daily for up to 6 months. Results: Urine protein/urine creatinine ratios were significantly (P , .05) lower with benazepril as compared with placebo at days 120 and 180. Three cats with placebo and 1 cat with benazepril were removed prematurely from the study because of deterioration of CRI or death. Cats were classified into 4 stages of CRI according to the International Renal Interest Society (IRIS) classification scheme. Incidence rates of cats with IRIS classification stage 2 or stage 3 that remained in stage 2 or 3 without progressing to stage 4 were higher with benazepril (93 6 5%) as compared with placebo (73 6 13%). Clinical Importance: These results suggest a potential for benazepril to delay the progression of disease, extend survival time, or both in cats with CRI.
Bariatric Surgery for Severe Obesity: Determinants of Use and Economic Impact

Bariatric Surgery for Severe Obesity: Determinants of Use and Economic Impact Rafael Alfonso Cristancho Chair of the Supervisory Committee: Sean D. Sullivan, PhD Objectives: Obesity in the U.S. population is a major public health problem with important clinical and economic implications. Bariatric surgery is currently the most effective longterm weight loss treatment for morbid obesity but less than 2% of the potentially eligible population has undergone the procedure. Our aims were to: 1) determine the patient characteristics associated with receiving a bariatric procedure among eligible patients; 2) identify patient characteristics that could be used as predictors of resource use and costs in severely obese patients with and without bariatric surgery; and 3) estimate and project the differences in long-term costs and outcomes across different clinically defined populations undergoing bariatric surgery compared to non-surgical approaches, refining a previously developed cost-effectiveness model. Methods: We used electronic medical records from members of Group Health Cooperative, based in Washington State to identify severely obese individuals, eligible for bariatric surgery, from 2004 to 2010. The probability of undergoing bariatric surgery was assessed using multivariate logistic regression adjusting for demographic and clinical characteristics, as well as patterns of practice. To determine the predictors of costs, we used generalized
Vertebro-Basilar Ischaemia

I s C H A E M I A within the distribution of the vertebro-basilar system may cause infarction in the brain stem, the diencephalon and the occipital lobe. If the main trunk of the basilar artery is occluded there will be a major stroke with loss of consciousness, bilateral hemiplegia and ocular palsies, frequently but not always followed by death (Kubik & Adams, 1946). If the disturbance is confined to the distribution of one of the smaller vessels, such as the posterior inferior cerebellar artery, there will be an acute focal disturbance, which may be followed by partial recovery. Transient ischaemic episodes are particularly liable to occur within the vertebro-basilar distribution and while these may run a recurrent and progressive course and lead to infarction, in many instances they occur in minor form over the years giving rise to much chronic disability. This syndrome of vertebro-basilar insufficiency, which has only been recognised in recent years, now constitutes one of the commonest conditions encountered in neurological practice.
Molecular imaging as a tool in drug delivery, oncology, and regenerative medicine

s (first author only) 1. P. Sanches, R. Rossin, E. Kaijzel, I Que, R Hoeben, C.W. G.M. Löwik, H. Grüll, “Multimodality imaging of bone metastases”, 18 NKRV workshop, Netherlands, 2013 2. P. Sanches, R. Rossin, E. Kaijzel, I Que, R Hoeben, C.W. G.M. Löwik, H. Grüll, “Multimodality imaging of breast cancer bone metastases”, World Molecular Imaging Conference, Ireland, 2012 3. P. Sanches, M. Mühlmeister, K. Tiemann, H. Grüll, “Ultrasound-mediated gene delivery to skeletal muscles in vivo”, International Society of Therapeutic Ultrasound Symposium, Germany, 2012 4. P. Sanches, M. Böhmer, K. Tiemann, H. Grüll, “In vivo gene transfection mediated by focused ultrasound”. World Molecular Imaging Conference, USA, 2011 5. P. Sanches, R. Rossin, M. Böhmer, K. Tiemann, H. Grüll, “Ultrasound drug delivery: in vivo SPECT/CT imaging and quantification”, Biomedica Life Science Summit, Netherlands, 2011 6. P. Sanches, R. Rossin, M. Böhmer, K. Tiemann, H. Grüll, “Focused ultrasound induced extravasation: in vivo SPECT/CT imaging and quantification”, Topics in Molecular Imaging Conference, France, 2011 7. P. Sanches,R. Rossin, M. Böhmer, K. Tiemann, K. Nicolaij, H. Grüll, "In vivo SPECT/CT imaging of focused ultrasound induced extravasation. " Nuclear Medicine and Biology 37(6): 722-722, 2010 List of publications 164 8. P. Sanches,R. Rossin, M. Böhmer, K. Tiemann, K. Nicolaij, H. Grüll, “In vivo SPECT/CT imaging of focused ultrasound-induced extravasation”, Technetium and Other Radiometals in Chemistry and Medicine Symposium, Italy, 2010 9. P. Sanches,R. Rossin, M. Böhmer, K. Tiemann, K. Nicolaij, H. Grüll, “Quantification of ultrasound-mediated local drug delivery with nuclear techniques”, Biomedica Life Science Summit, Germany, 2010 10. P. Sanches,R. Rossin, M. Böhmer, K. Tiemann, H. Grüll, “SPECT-CT imaging and quantification of focused ultrasound induced extravasation”, 15 European Symposium on Ultrasound Contrast Imaging, Netherlands, 2010 Conference proceedings (published) 1. P. Sanches,R. Rossin, M. Böhmer, K. Tiemann, K. Nicolaij, H. Grüll, “In vivo SPECT/CT imaging of focused ultrasound induced extravasation”, in: U. Mazzi, W.C. Eckelman, W.A. Volkert (Eds.) Technetium and Other Radiometals in Chemistry and Medicine, SGEditorali, Padova, Italy, pp. 547-550. ISBN 9788889884140, 2010 (Proceedings Terachem 2010 conference) Invited presentations 1. Sanches et al. “Multimodal molecular imaging an overview of studies in our laboratories”, Bioscan User Meeting, Ireland, 2012 Invited Lecturer 1. Topic: “The axolotl: an animal model for regenerative medicine”, Working with laboratory animals, Dutch Article 9, University of Maastricht, Netherlands, since 2013
Ezetimiba - farmacocinética e terapêutica Ezetimibe - pharmacokinetics and therapeutics

A doenca aterosclerotica e na atualidade uma dasmaiores causas de obito, principalmente nos paises comestilo de vida ocidental. Baixos niveis de HDL colesterol(HDL-C) contrapostos com elevadas concentracoesplasmaticas de triglicerides e LDL colesterol (LDL-C) estaoconsistentemente relacionados com aumento do riscode eventos cardiovasculares ¹
Vitamin D deficiency and resistance state association with clinical and immunological deregulation in systemic lupus erythematosus

publications 1. Marinho, António J.; Vasconcelos, Carlos; Farinha, Fátima; Rocha, Guilherme; Almeida, Isabel; Correia, João; Mendonça, Teresa; Barbosa, Paulo. Don’t forget what natural SLE history is teaching us when establishing clinical-genetic correlations – Poster. 9th International Congress on Systemic Lupus Erythematosus June 24-27, 2010, Vancouver, Canada. Lupus. 2010 Jun;19 Suppl 1:1-185. doi: 10.1177/09612033100190010101. 2. Sá N, Ferreira B, Brandão M, Marinho A, Almeida I, Mendonça T, Correia J, Farinha F, Vasconcelos C. In-Hospital mortality review in lupus patients – Poster. 8th European Lupus Meeting. Oporto 2011. Lupus. 2011 Apr;20(4):339-437. doi: 10.1177/0961203311404766. 3. Carvalho C, Marinho A, Leal B, Bettencourt A, Costa PP, Almeida I, Farinha F, Oliveira JC, Vasconcelos C, Silva BM. Vitamin D receptor Fokl polymorphism in Portuguese patients with systemic lupus erythematosus – Poster. 8th European Lupus Meeting. Oporto 2011. Lupus. 2011 Apr;20(4):339-437. doi: 10.1177/0961203311404766. Contribuition: clinical evaluation of Lupus patients and database registry. Major Works presented in Congress
Nipple-Sparing Mastectomy

T: +302651099791 F: +302651040812 Email: deziogas@hotmail.com Many women are undergoing surgery for breast cancer with the probability of nipple preservation. Cosmetic outcome and patient satisfaction following nipple-sparing mastectomy (NSM) are thought to be superior to after standard mastectomy. So, why is NSM still considered experimental? What are the oncological concerns about, the technical demands of, and the indications for NSM?
Who Compares to Whom? The Anatomy of Income Comparisons in Europe

This article provides unprecedented direct evidence from large-scale survey data on both the intensity (how much? ) and direction (to whom? ) of income comparisons. Income comparisons are considered to be at least somewhat important by three-quarters of Europeans. They are associated with both lower levels of subjective well-being and a greater demand for income redistribution. The rich compare less and are happier than average when they do, which latter is consistent with relative income theory. With respect to the direction of comparisons, colleagues are the most frequentlycited reference group. Those who compare to colleagues are happier than those who compare to other benchmarks.
Benefits of Catheter Thrombectomy during Carotid Stenting

Despite the use of distal embolic protection devices (DEPs) in carotid artery (CA) stenting, an appreciable risk of stroke exists, particularly in symptomatic patients. The mechanism of embolic events is possibly related to microembolization of atherothrombotic debris that remains or forms on the stent struts. This study evaluated the safety of using thrombus-extraction catheters in the setting of CA stenting.From August 2006 through June 2008, 43 symptomatic and asymptomatic patients with severe CA stenosis (
PHYSIOLOGICAL ROLE OF THE BLADDER ALPHA1D-ADRENOCEPTOR IN THE ACTIVATION OF SINGLE-UNIT PRIMARY BLADDER AFFERENT ACTIVITY IN RATS

Hypothesis / aims of study Clinical observation have revealed that a relatively selective α1D-adrenoceptor (α1D-AR) antagonist, naftopidil, improve not only voiding symptoms but also storage symptoms in men with LUTS/BPH (1). As harmonized with such observation, an animal study demonstrated that systemically administrated naftopodil elongated voiding interval in cystometry and inhibited the mechanosensitive multiple bladder afferent activities (2). However, direct effects of bladder α1D-AR-inhibition on the individual mechanosensitive afferent activity innervating the bladder have not been evaluated yet. In the present study, we investigated the effect of intravenous and intravesical administrations of BMY7378, a highly selective α1D-AR antagonist, on mechanosensitive single-unit afferent activities (SAAs) of the primary bladder afferent nerves in rats.
Are visible minorities “invisible” in Canadian health data and research? A scoping review

Purpose Canada’s visible minority population is increasing rapidly, yet despite the demographic significance of this population, there is a surprising dearth of nationally representative health data on visible minorities. This is a major challenge to undertaking research on the health of this group, particularly in the context of investigating racial/ethnic disparities and health disadvantages that are rooted in racialization. The purpose of this paper is to summarize: mortality and morbidity patterns for visible minorities; determinants of visible minority health; health status and determinants of the health of visible minority older adults (VMOA); and promising data sources that may be used to examine visible minority health in future research. Design/methodology/approach A scoping review of 99 studies or publications published between 1978 and 2014 (abstracts of 72 and full articles of 27) was conducted to summarize data and research findings on visible minority health to answer four specific questions: what is known about the morbidity and mortality patterns of visible minorities relative to white Canadians? What is known about the determinants of visible minority health? What is known about the health status of VMOA, a growing segment of Canada’s aging population, and how does this compare with white older adults? And finally, what data sources have been used to study visible minority health? Findings There is indeed a major gap in health data and research on visible minorities in Canada. Further, many studies failed to distinguish between immigrants and Canadian-born visible minorities, thus conflating effects of racial status with those of immigrant status on health. The VMOA population is even more invisible in health data and research. The most promising data set appears to be the Canadian Community Health Survey (CCHS). Originality/value This paper makes an important contribution by providing a comprehensive overview of the nature, extent, and range of data and research available on the health of visible minorities in Canada. The authors make two key recommendations: first, over-sampling visible minorities in standard health surveys such as the CCHS, or conducting targeted health surveys of visible minorities. Surveys should collect information on key socio-demographic characteristics such as nativity, ethnic origin, socioeconomic status, and age-at-arrival for immigrants. Second, researchers should consider an intersectionality approach that takes into account the multiple factors that may affect a visible minority person’s health, including the role of discrimination based on racial status, immigrant characteristics for foreign-born visible minorities, age and the role of ageism for older adults, socioeconomic status, gender (for visible minority women), and geographic place or residence in their analyses.
Personalized cancer medicine guided by liquid biopsies

markdownabstractThe capacity to optimally treat cancer patients is nowadays challenged by several factors. These challenges are particularly caused by tumor heterogeneity and plasticity, causing tumor characteristics to change over time and under treatment pressure. The use of liquid biopsies sampled from the blood of patients with cancer is a promising way to evaluate tumor characteristics and response to therapy repeatedly during therapy. In the long run, the availability of these sort of biomarkers which can tailor the right therapeutic strategy, for the right person, at the right time, is where we can use knowledge on the biology of cancer to treat cancer in the most optimal fashion. This thesis has focused on several technical and clinical aspects of liquid biopsies, all with the ultimate aim to allow personalized medicine based on these liquid biopsies.
Rural male caregivers : experiences, meanings, and processes

Title: Rural Male Caregivers: Experiences, Meanings, and Processes Author: 2 Deborah Messecar, MPH, PhD, RN, CNS Considering the realities of an aging American population, the anticipated growing need for informal caregivers, the substantial numbers of men caring for loved ones at home, and the challenges of health and human service delivery in rural areas, nurses should be concerned that virtually nothing is known about how rural men implement caregiving. The paucity of knowledge regarding this group of caregivers may mask a looming men's health issue, which if not explored, will affect these men and their care recipients. This qualitative study used constructivist grounded theory methods to explore the experiences and process of caregiving for rural men. Twelve male caregivers residing in frontier areas of Montana and Oregon, recruited from newspaper advertisements, provided interviews lasting from 45-120 minutes in total. The participants had provided care to female family members for between 1-28 years. From the data, a theoretical model was constructed proposing how rurality and rural masculinity influence caregiving. For these participants, challenges attributed to caregiving, rural masculinity, and rurality increased stress and pushed caregivers toward crisis. Resources attributed to financial sources, rural masculinity, and rurality reduced stress. Increased caregiver demands required participants to adopt perspectives and behaviors inconsistent with constructed gender. With increased levels of stress,
Toshiba Aquilion 64 -TT-laitteistoon perehtyminen Moodle-ympäristössä. : Esimerkkinä pään natiivi-TT-tutkimus.

Tampereen ammattikorkeakoulu Tampere University of Applied Sciences Degree Programme in Radiography and Radiotherapy JULKUNEN, MARKKU & SULKALA, ERKKI Familiarizing with the use of the Toshiba Aquilion 64 -CT-equipment in the Moodle environment. Native CT-scanning of the head as an example. Bachelor’s thesis 43 pages, appendices 3 pages October 2010 _______________________________________________________________ The advancement of modern technology has opened new avenues for the development of teaching and learning. The introduction of technology has increased flexibility in education and given rise to virtual learning environments which offer learning opportunities independent on time and place. Moodle is a free virtual on-line learning environment the purpose of which is to support active search for information and interactive learning. The Radiology Unit of the Central Finland Health Care District is the annual venue of professional practical training for students of radiography who familiarize themselves with CT scanning during a period of three to five weeks. The need to use a radiographer’s work input for the orientation of the students is diminished if the students can independently familiarize themselves with the use of the equipment during their practical placement. The purpose of the present thesis was to enhance the orientation procedures for the students in the Radiology Unit of the Central Finland Health Care District. The aim was to produce web-based orientation material for the students of radiography. The content of the material focused on the process of the cephalic region CT-scan with the Toshiba Aquilion 64 CT-equipment. The material, which was created in the Moodle environment of the Central Finland Health Care District and which utilizes the interactive and audiovisual opportunities of the environment, contains the orientation into the general aspects of the CT-scanning process as well as into the virtual, native CT-scanning of the head with the Toshiba Aquilion 64 CT-equipment. The material was constructed in such a way that it can be updated for other target groups and extended to concern other examinations. A test-run was performed on the material, and the related feedback was used as a basis for improvements. According to the user experiences gained from the test-run, the orientation into the Toshiba Aquilion 64 CT-equipment was seen as flexible, and the subject matter was deemed easy to learn. The interactive nature of the material was found positive, and the performance of the virtual head scan was experienced as being illustrative and highly educational. In the future it would be useful to compile similar interactive materials on other examinations into the Moodle environment. _______________________________________________________________
Effect of Ephedrine on Pain and Hemodynamic Status on Injection of Propofol

Background : Propofol is one of the drugs most commonly used during induction of anesthesia. The induction dose of propofol can lead to hemodynamic changes such as hypotension and bradycardia. Pain on injection is another side effect of propofol. The purpose of this study was to evaluate the effect of two different doses of ephedrine on hemodynamic status and pain on injection of propofol compared to lidocaine and placebo. Methods : In the present study, 100 patients were enrolled. A 22 gauge cannula was inserted into the veins on the non-dominant hand of all patients. The patients were randomly allocated to 4 groups and 10 ml/kg of saline was administered over 10 minutes from each of the cannulas. Then, patients received either of these pretreatments: 2 ml of Saline (group S); 2 ml lidocaine 2% (40 mg) (group L); Ephedrine (30 ug/kg) (group E1); or Ephedrine (70 ug/kg) (group E2). After 30 seconds all patients were administered 2.5 mg/kg of propofol with a rate of 1 ml per second. The patients were asked to give a score from 0 to 10 (0 = no pain and 10 = most severe pain) every 5 seconds until loss of consciousness. Systolic and diastolic pressures and heart rate were recorded before induction of anesthesia, before intubation, and 1, 3, and 5 minutes after intubation. Results : Systolic, diastolic, and mean arterial pressure and heart rate following induction in E1 and E2 groups were higher than S and L groups (P < 0.001). There were no differences in systolic, diastolic, and mean arterial pressure and heart rate 1, 3, and 5 minutes after intubation between groups. Lidocaine and both doses of ephedrine reduced pain on injection of propofol similarly. Conclusions : Lidocaine and high and low doses of ephedrine reduce the intensity of pain on injection of propofol. Small doses of ephedrine attenuate blood pressure and heart rate reduction after induction of anesthesia with propofol.