Miracle-dz/UniFAR-FTUs huggingface dataset:
Romanticism's Gray Matter

The antagonism between science and the humanities is an old story, one whose basic themes were inspired by a new understanding of the utility of science that emerged from the Enlightenment. If faith in the efficacy of human reason to renew human society was no longer quite so robust after Robespierre’s Reign of Terror, science itself did not suffer but instead assumed the central place in intellectual inquiry. Half a century later, the opposition between humanistic inquiry and science not only carried over into the conception of literary studies in its embryonic phase as an academic discipline; the rise of science provided, ironically, a primary impetus for the institutionalization of English studies, since the study of language and literature was envisioned as an arena of spiritual values and social polish. But according to Gerald Graff, the picture is even more complicated than this: the oppositions between literature and science are largely matched by those within English/literary studies from the very beginning. If English was envisioned as a repository of value and cultivation on the one hand, it was driven, under the influence of science, to professionalize and develop a research industry on the other—which itself fostered a divide between criticism and academic research, areas that have only recently come together.1
Plant Tandem CCCH Zinc Finger Proteins Interact with ABA, Drought, and Stress Response Regulators in Processing-Bodies and Stress Granules

Although multiple lines of evidence have indicated that Arabidopsis thaliana Tandem CCCH Zinc Finger proteins, AtTZF4, 5 and 6 are involved in ABA, GA and phytochrome mediated seed germination responses, the interacting proteins involved in these processes are unknown. Using yeast two-hybrid screens, we have identified 35 putative AtTZF5 interacting protein partners. Among them, Mediator of ABA-Regulated Dormancy 1 (MARD1) is highly expressed in seeds and involved in ABA signal transduction, while Responsive to Dehydration 21A (RD21A) is a well-documented stress responsive protein. Co-immunoprecipitation (Co-IP) and bimolecular fluorescence complementation (BiFC) assays were used to confirm that AtTZF5 can interact with MARD1 and RD21A in plant cells, and the interaction is mediated through TZF motif. In addition, AtTZF4 and 6 could also interact with MARD1 and RD21A in Y-2-H and BiFC assay, respectively. The protein-protein interactions apparently take place in processing bodies (PBs) and stress granules (SGs), because AtTZF5, MARD1 and RD21A could interact and co-localize with each other and they all can co-localize with the same PB and SG markers in plant cells.
SAFS3 algorithm: Frequency statistic and semantic similarity based semantic classification use case

Sentiment analysis on movie reviews is a topic of interest for artists and businessmen alike for the purpose of gauging the reception of an artwork or to understand the trends in the market for the benefit of future productions. In this study we introduce an algorithm (SAFS3) to classify documents into multiple classes. This paper then evaluates the SAFS3 algorithm through the use case of analysing a set of reviews from Rotten Tomatoes. Thenovel algorithm results in an accuracy of 53.6%. SAFS3 algorithm outperforms the benchmark for this context as well as the set of generic machine learning algorithms commonly used for tasks of this nature.
Língua(gem) como Veículo do Pensamento

Este trabalho oferece uma revisao teorica sobre alguns conceitos e diferencas entre lingua e linguagem a partir de perspectivas linguisticas de Saussure (2006), Chomsky (1997; 1998), Pinker (2002), Sapir (2004) e Perini (2003), sociointeracionista de Vygotsky (2005) e filosofica de Wittgenstein (1991). Partindo desses conceitos, discutem-se as relacoes entre linguagem e pensamento, percebendo a lingua como um modo proprio de interpretar a realidade. Nessa perspectiva, buscou-se pontuar como a relacao entre linguagem, pensamento e contexto cultural pode interferir no processo de aquisicao de uma lingua. Concluiu-se que existe uma forte relacao entre a linguagem e o desenvolvimento do pensamento, bem como cada lingua descreve/interpreta a realidade de modos diferentes, logo, apropriar-se de uma determinada lingua implica, antes de tudo, compreender o universo cultural de seus falantes.
Aplicação dos polinômios de Chebyshev

Neste artigo e apresentada uma visao geral sobre o problema da identificacao de sistemas nao lineares, tipo Wiener, operando em malha aberta. Existem diversos algoritmos que solucionam este problema, entre eles encontram-se os metodos por subespacos. Baseados nos metodos por subespacos e os polinomios de Chebyshev e apresentada uma metodologia para a identificacao de um sistema nao linear do tipo Wiener. Os metodos por subespacos usados sao MOESP e N4SID. Um exemplo simulado e apresentado para comparar o desempenho destes algoritmos
Microarray Gene-expression Profiling Analysis Comparing PCNSL and Non-CNS Diffuse Large B-Cell Lymphoma.

AIM The purpose of the present study was to compare microarray gene-expression profiling data between primary central nervous system (CNS) lymphoma and non-CNS lymphomas. MATERIALS AND METHODS We performed whole-genomic cDNA-mediated annealing, selection and ligation assay with 177 formalin-fixed paraffin-embedded tumor samples. RESULTS We identified 20 differentially expressed genes out of which 5 were predominantly expressed in CNS DLBCL compared to non-CNS DLBCL (C16orf59, SLC16A9, HPDL, SPP1, and MAG). SLC16A9 may be involved in aerobic glycolysis of malignant tumors. The alteration in gene expression of SPP1 in primary CNS lymphoma is involved in biological activity, such as CNS tropism, B-cell migration, proliferation, and aggressive clinical behavior. MAG may be an important adhesion molecule that contributes to perineural cancer invasion. CONCLUSION Genomic differences between CNS and non-CNS DLBCL exist and the most prominent genes are SPP1 and MAG. SPP1 may play a key role in CNS tropism of primary CNS lymphoma.
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1

Heme controls expression of genes involved in the synthesis of globins and heme. The mammalian transcription factor Bach1 functions as a repressor of the Maf recognition element (MARE) by forming antagonizing hetero‐oligomers with the small Maf family proteins. We show here that heme binds specifically to Bach1 and regulates its DNA‐binding activity. Deletion studies demonstrated that a heme‐binding region of Bach1 is confined within its C‐terminal region that possesses four dipeptide cysteine–proline (CP) motifs. Mutations in all of the CP motifs of Bach1 abolished its interaction with heme. The DNA‐binding activity of Bach1 as a MafK hetero‐oligomer was markedly inhibited by heme in gel mobility shift assays. The repressor activity of Bach1 was lost upon addition of hemin in transfected cells. These results suggest that increased levels of heme inactivate the repressor Bach1, resulting in induction of a host of genes with MAREs.
Body size, colony size, and range size in ants (Hymenoptera: Formicidae): are pat- terns along elevational and latitudinal gradients consistent with Bergmann's Rule?

Body size of organisms often increases with latitude and elevation, a pattern commonly called Bergmann's Rule. Though this pattern has been documented in many endothermic taxa, relatively few insect taxa have been examined, with some taxa showing strong support and other taxa showing little or no support for the rule. For colonial organisms (social insects, corals, bryozoans) size can also be estimated as the number of sub-units. Consequently, for ants the number of workers per colony should also increase with latitude or elevation. Here, we test whether body size or colony size is related to latitude and elevation for ants in eastern North America. We found no positive relationship between body size or colony size and elevation or latitude. However, species with large latitudinal ranges also had large elevational ranges, suggesting that species that are able to tolerate broad climatic conditions have the largest ranges. In addition, species with high latitudinal maxima also had high elevational maxima. Taken together, our results do not support Bergmann's Rule in ants, in contrast to other studies on ants. But climate imposes limits on ant distributions in similar ways along both elevational and latitudinal gradients.
IS JAKOBSON RIGHT?

In Europe there exist two systems for the mimic expressions of assent and dissent: System A, which is used by the great majority of Europeans (Czechs, Russians, English, French, Germans, etc.) and System B, which is found predominantly in Bulgaria (and outside Europe, in Asia Minor, for instance, among Turks). Both systems include two kinetic forms, vertical nodding and horizontal turning of the head, which are, however, used to express content that is contradictory:
A Software-Defined Device-to-Device Communication Architecture for Public Safety Applications in 5G Networks

The device-to-device (D2D) communication paradigm in 5G networks provides an effective infrastructure to enable different smart city applications such as public safety. In future smart cities, dense deployment of wireless sensor networks (WSNs) can be integrated with 5G networks using D2D communication. D2D communication enables direct communication between nearby user equipments (UEs) using cellular or ad hoc links, thereby improving the spectrum utilization, system throughput, and energy efficiency of the network. In this paper, we propose a hierarchal D2D communication architecture where a centralized software-defined network (SDN) controller communicates with the cloud head to reduce the number of requested long-term evolution (LTE) communication links, thereby improving energy consumption. The concept of local and central controller enables our architecture to work in case of infrastructure damage and hotspot traffic situation. The architecture helps to maintain the communication between disaster victims and first responders by installing multi-hop routing path with the support of the SDN controller. In addition, we highlight the robustness and potential of our architecture by presenting a public safety scenario, where a part of the network is offline due to extraordinary events such as disaster or terrorist attacks.
Detecting mitochondrial signatures of selection in wild Tibetan pigs and domesticated pigs

Abstract Selection in genomic regions is prevalent in mammals; however, the effects of selection on the mitogenome are not clearly understood. We determined the complete mitochondrial DNA (mtDNA) sequences from six wild Tibetan pigs from the Tibetan plateau and four domestic pig breeds from the lowland of neighboring southwest China. Nucleotide diversity analysis using the sliding window method showed that the nucleotide diversity of wild Tibetan pigs in most regions of the mitogenome was higher than that of domestic pigs. The 12 s ribosomal RNA showed relatively lower nucleotide diversity in Tibetan pigs, suggesting purifying selection of these genes during high-altitude adaptation. More non-synonymous nucleotide substitutions in the ATP6 were found in wild Tibetan pigs, indicating adaptive selection in Tibetan pigs. The results suggested distinct impacts of natural selection and artificial selection upon the mitogenome, especially the mitochondrial signatures of adaptive evolution in wild Tibetan pigs under natural selection.
A new register design for low power TLB and cache

This paper presents a new register design, called content-change-aware (CCA) register, to reduce the TLB/cache power consumption without delay penalty. By embedding the detection logic in the register, the CCA register is able to sense out the difference between the coming value and the current stored value. This property can be used to accurately filter out all the redundant TLB/cache accesses in real-time. We remove the comparison delay penalty from the conventional block buffering without impairing the power reduction efficiency. Applying the proposed CCA register to the TLB/cache with a single block buffer, the experimental results show that our design can drastically reduce the average power consumption per TLB/cache access as achieved by using the block buffering, but without compromise of system performance.
Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.

OBJECTIVE This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. METHOD A broadly representative adult outpatient sample with nonpsychotic major depressive disorder received one (N=3,671) to four (N=123) successive acute treatment steps. Those not achieving remission with or unable to tolerate a treatment step were encouraged to move to the next step. Those with an acceptable benefit, preferably symptom remission, from any particular step could enter a 12-month naturalistic follow-up phase. A score of <or=5 on the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR(16)) (equivalent to <or=7 on the 17-item Hamilton Rating Scale for Depression [HRSD(17)]) defined remission; a QIDS-SR(16) total score of >or=11 (HRSD(17)>or=14) defined relapse. RESULTS The QIDS-SR(16) remission rates were 36.8%, 30.6%, 13.7%, and 13.0% for the first, second, third, and fourth acute treatment steps, respectively. The overall cumulative remission rate was 67%. Overall, those who required more treatment steps had higher relapse rates during the naturalistic follow-up phase. In addition, lower relapse rates were found among participants who were in remission at follow-up entry than for those who were not after the first three treatment steps. CONCLUSIONS When more treatment steps are required, lower acute remission rates (especially in the third and fourth treatment steps) and higher relapse rates during the follow-up phase are to be expected. Studies to identify the best multistep treatment sequences for individual patients and the development of more broadly effective treatments are needed.
Uptake of Metal Ions by Rhizopus arrhizus Biomass

Rhizopus arrhizus biomass was found to absorb a variety of different metal cations and anions but did not absorb alkali metal ions. The amount of uptake of the cations was directly related to ionic radii of La3+, Mn2+, Cu2+, Zn2+, Cd2+, Ba2+, Hg2+, Pb2+, UO22+, and Ag+. The uptake of all the cations is consistent with absorption of the metals by sites in the biomass containing phosphate, carboxylate, and other functional groups. The uptake of the molybdate and vanadate anions was strongly pH dependent, and it is proposed that the uptake mechanism involves electrostatic attraction to positively charged functional groups.
El evolucionismo y las ideologías políticas

Este articulo discute las implicaciones etico-politicas que han seguido atribuyendose al darwinismo en las numerosas obras publicadas a raiz del bicentenario del nacimiento de Darwin. Analiza la relacion del darwinismo con el materialismo, el marxismo, el darwinismo social, la eugenesia, el conservadurismo, el creacionismo y el ateismo, distinguiendo las justificadas asociaciones de ciertas hipotesis biologicas con varias tendencias politicas y la injustificada asociacion del evolucionismo con distintas ideologias
Mechanism of Radical-based Catalysis in the Reaction Catalyzed by Adenosylcobalamin-dependent Ornithine 4,5-Aminomutase*

We report an analysis of the reaction mechanism of ornithine 4,5-aminomutase, an adenosylcobalamin (AdoCbl)- and pyridoxal l-phosphate (PLP)-dependent enzyme that catalyzes the 1,2-rearrangement of the terminal amino group of d-ornithine to generate (2R,4S)-2,4-diaminopentanoic acid. We show by stopped-flow absorbance studies that binding of the substrate d-ornithine or the substrate analogue d-2,4-diaminobutryic acid (DAB) induces rapid homolysis of the AdoCbl Co–C bond (781 s–1, d-ornithine; 513 s–1, DAB). However, only DAB results in the stable formation of a cob(II)alamin species. EPR spectra of DAB and [2,4,4-2H3]DAB bound to holo-ornithine 4,5-aminomutase suggests strong electronic coupling between cob(II)alamin and a radical form of the substrate analog. Loading of substrate/analogue onto PLP (i.e. formation of an external aldimine) is also rapid (532 s–1, d-ornithine; 488 s–1, DAB). In AdoCbl-depleted enzyme, formation of the external aldimine occurs over long time scales (∼50 s) and occurs in three resolvable kinetic phases, identifying four distinct spectral intermediates (termed A–D). We infer that these represent the internal aldimine (λmax 416 nm; A), two different unliganded PLP states of the enzyme (λmax at 409 nm; B and C), and the external aldimine (λmax 426 nm; D). An imine linkage with d-ornithine and DAB generates both tautomeric forms of the external aldimine, but with d-ornithine the equilibrium is shifted toward the ketoimine state. The influence of this equilibrium distribution of prototropic isomers in driving homolysis and stabilizing radical intermediate states is discussed. Our work provides the first detailed analysis of radical-based catalysis in this Class III AdoCbl-dependent enzyme.
In vitro interactions between different beta-lactam antibiotics and fosfomycin against bloodstream isolates of enterococci

The effects of 16 different beta-lactam-fosfomycin combinations against 50 bloodstream enterococci were compared by a disk diffusion technique. Cefotaxime exhibited the best interaction. By checkerboard studies, the cefotaxime-fosfomycin combination provided a synergistic bacteriostatic effect against 45 of the 50 isolates (MIC of cefotaxime at which 90% of the isolates were inhibited, >2,048 micrograms/ml; MIC of fosfomycin at which 90% of the isolates were inhibited, 128 micrograms/ml; mean of fractional inhibitory concentration indexes, 0.195). By killing curves, cefotaxime (at 64 micrograms/ml) combined with fosfomycin (at > or = 64 micrograms/ml) was bactericidal against 6 of 10 strains tested.
Olanzapine-induced cerebral metabolic changes related to symptom improvement in schizophrenia

The pattern of brain metabolic changes produced by olanzapine has yet to be described, despite the theoretical and clinical interest of this new antipsychotic. We studied a group of 17 schizophrenic patients who underwent two 18fluoro-deoxyglucose-positron emmission tomography (FDG-PET) studies under two different conditions: a baseline scan during treatment with either conventional antipsychotics (n=15) or risperidone (n=2) and a second scan performed 17–24 weeks after switching to olanzapine. PET scans were obtained while performing a standard cognitive paradigm (Continuous Performance Test) and analysed by means of Statistical Parametric Mapping. No significant metabolic changes were found in the comparison between pre- and post-olanzapine conditions. A brain map of the statistical power of our design showed that changes up to 3% in the frontal and up to 8% in the occipital region were not likely to exist (1–&bgr;=0.8). The degree of improvement in positive symptoms was related to the amount of activity decrease in the right orbital region and to the amount of activity increase in the primary visual area. Improvement in negative symptoms was associated with an activity increase in the dorsal prefrontal cortex, and a higher baseline activity in both temporal poles. These correlation patterns suggest that the functional mechanism of action of olanzapine may share traits from both typical and atypical neuroleptics.
Effects of arterial carbon dioxide tension and oxygen saturation on cerebral blood flow autoregulation in dogs.

Effects of arterial carbon dioxide tension and oxygen saturation on cerebral blood flow autoregulation in dogs. Acta physiol. scand. 1965. 66. Suppl. 258. 27–53. - Pressure-flow relation- ships of the cerebral circulation under influence of variations in arterial carbon dioxide tension and oxygen saturation were studied in pentobarbital anaesthetized dogs. Cerebral blood flow was measured by recording of the γ- emission of radioactive krypton (Kr85), which was injected into the vertebral artery. The recorded desaturation curve was resolved into two exponential phases and the fast phase was considered as representative of blood flow in the grey matter of the brain. It was demonstrated that autoregulation of flow occurred within wide pressure limits under normo- and hypocapnia. Auto-regulation was less pronounced under hypercapnia and was abolished at low arterial oxygen saturation. Possible mechanisms of autoregulation of cerebral blood flow are discussed. Evidences are presented which speak against the theory that changes in the carbon dioxide tension are the main cause of this autoregulation. The results from previous studies concerning the principal effects of arterial carbon dioxide tension and oxygen saturation on cerebral blood flow were confirmed.
How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis.

OBJECTIVE To develop a clinical model for the prediction, at the first visit, of 3 forms of arthritis outcome: self-limiting, persistent nonerosive, and persistent erosive arthritis. METHODS A standardized diagnostic evaluation was performed on 524 consecutive, newly referred patients with early arthritis. Potentially diagnostic determinants obtained at the first visit from the patient's history, physical examination, and blood and imaging testing were entered in a logistic regression analysis. Arthritis outcome was recorded at 2 years' followup. The discriminative ability of the model was expressed as a receiver operating characteristic (ROC) area under the curve (AUC). RESULTS The developed prediction model consisted of 7 variables: symptom duration at first visit, morning stiffness for > or =1 hour, arthritis in > or =3 joints, bilateral compression pain in the metatarsophalangeal joints, rheumatoid factor positivity, anti-cyclic citrullinated peptide antibody positivity, and the presence of erosions (hands/feet). Application of the model to an individual patient resulted in 3 clinically relevant predictive values: one for self-limiting arthritis, one for persistent nonerosive arthritis, and one for persistent erosive arthritis. The ROC AUC of the model was 0.84 (SE 0.02) for discrimination between self-limiting and persistent arthritis, and 0.91 (SE 0.02) for discrimination between persistent nonerosive and persistent erosive arthritis, whereas the discriminative ability of the American College of Rheumatology 1987 classification criteria for rheumatoid arthritis was significantly lower, with ROC AUC values of 0.78 (SE 0.02) and 0.79 (SE 0.03), respectively. CONCLUSION A clinical prediction model was developed with an excellent ability to discriminate, at the first visit, between 3 forms of arthritis outcome. Validation in other early arthritis clinics is necessary.
2,3,7,8-Tetrachlorodibenzo-p-dioxin: A Potent Inducer of δ-Aminolevulinic Acid Synthetase

2,3,7,8-Tetrachlorodibenzo-p-dioxin, a toxic contaminant frequently formed during the synthesis of the herbicide 2,4,5-trichlorophenoxyacetic acid, was shown to be a potent inducer of hepatic δ-aminolevulinic acid synthetase in the chick embryo. As little as 4.66 x 10-12 mole of the contaminant per egg produces a significant increase in the activity of the enzyme. Induction of the enzyme is related to the dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin and, in contrast to that produced with other drugs, is prolonged in time, with 70 percent of the maximum induced activity present 5 days after a single dose. This contaminant is implicated as the likely causative agent in an outbreak of porphyria cutanea tarda in workers in a factory where 2,4,5-trichlorophenoxyacetic acid was being synthesized.