Miracle-dz/UniFAR-FTUs huggingface dataset:
Minimal recovery time needed to return to social engagement following nasolabial fold correction with hyaluronic acid fillers produced with XpresHAn technology

Introduction The appeal of hyaluronic acid fillers for facial soft tissue augmentation is attributable to both an immediate aesthetic effect and relatively short recovery time. Although recovery time is an important posttreatment variable, as it impacts comfort with appearance and perceived treatment benefit, it is not routinely evaluated. Natural-looking aesthetic outcomes are also a primary concern for many patients. Materials and methods A single-center, noncomparative study evaluated the time (in hours) until subjects return to social engagement (RtSE) following correction of moderate and severe nasolabial folds (NLFs) with RR (Restylane® Refyne)® and RD (Restylane Defyne), respectively. Twenty subjects (aged 35–57 years) who received bilateral NLF correction documented their RtSE and injection-related events posttreatment. Treatment efficacy was evaluated by improvements in Wrinkle Severity Rating Scale (WSRS) and subject satisfaction questionnaire at days 14 and 30, and by Global Aesthetic Improvement Scale (GAIS) at day 30. Safety was evaluated by injection-related events and treatment-emergent adverse events. Results Fifty percent of subjects reported RtSE within 2 hours posttreatment. WSRS for the RR group improved significantly from baseline at day 14 (–1.45±0.42) and day 30 (–1.68±0.46) (P<0.001), respectively. WSRS for the RD group improved significantly from baseline at day 14 (–2.22±0.44) and day 30 (–2.50±0.50) (P<0.004), respectively. All GAIS improvements were clinically significant at day 30. The majority of injection-related events were mild or moderate. Two subjects experienced 3 related treatment-emergent adverse events; 1 RR subject experienced severe bruising, and 1 RD subject experienced severe erythema and mild telangiectasia. Subject satisfaction was high regarding aesthetic outcomes and natural-looking results. Conclusion Optimal correction of moderate NLFs with RR and severe NLFs with RD involved minimal time to RtSE for most subjects. Treatments that significantly improved WSRS and GAIS, were generally well-tolerated, and provided natural-looking aesthetic outcomes.
Power Control Combined with Routing Protocol for Wireless Sensor Networks

Energy-efficient routing protocol is a key issue in designing a wireless sensor network. The AODV is a routing protocol that depends only on hopcount number, but not on energy and power [1]. This leads to central nodes' exhaustion of energy and influences the entire network lifetime. In this paper, we propose a new power control mechanism in combination with routing protocol improved from the AODV. The proposed protocol is named as the Power-Control Combined with Routing Protocol (PRP for short). Simulation results show that the lifetime and energy of the networks deployed our protocol outperform than that obtained by the AODV protocol.
A Mixture Model of Arterial Growth and Remodeling in Hypertension: Altered Muscle Tone and Tissue Turnover

Hypertension results in a thickening of the arterial wall due to a net increase in wall constituents via a coordinated production and removal of smooth muscle and extracellular matrix. Although many reports address the associated changes in material properties, few models address the biomechanics of the growth and remodeling process. In this paper, we employ a new, fundamentally different approach to modeling arterial adaptation in hypertension. In particular, basic, characteristic features of hypertension are simulated using a constrained mixture model wherein individual constituents can turnover at different rates and can have different natural configurations. We show, for example, that if there is no turnover of elastin (which approximates responses in maturity), the model vessel is able to reduce an early elevation in wall stress via a thickening of the wall even though the adaptation may be suboptimal. Conversely, if all constituents can turnover completely (which may approximate late development), the model vessel can restore the state of stress and material properties to native values. Given the potential of such a model, there is a need for more data on the history of turnover of individual constituents and their individual material properties.
THE QUALITY OF ACTIVE MASS AND SEGMENTAL FLUIDS BODY DISTRIBUTION IN YOUNG ELITE SOCCER PLAYERS

Purpose: The aim of the study was to compare parameters identifying the quality of active mass as a predisposition for performance in elite soccer teams of junior and adolescent categories and also to present distribution of fluids in individual segments, which absents in the literature, with indication of asymmetry and possible muscle imbalance. Material and methods: The screened sample was composed of two elite soccer teams from Czech Republic. The first team (junior team, n = 50, age = 20.04 ± 2.69 years, body height = 180.48 ± 6.52, body mass = 74.78 ± 8.42 kg) was a leader of the junior Czech league (two season, cohort teams). The second team (adolescent team, n = 33, age = 16.15 ± 0.87 years, body height = 177.44 ± 7.65, body mass = 67.55 ± 8.99 kg) was a leader of the Czech soccer league U17 category.Body composition was measured using the bioimpedance method. Results: Total body water demonstrated a significant difference between the monitored groups (p 0.05). We did not record significant differences in comparison of the upper limbs, but lower limbs revealed significant differences in muscle mass proportion (Junior team: t = 7.319; p< 0.01, Adolescent team: t = 12.087; p< 0.01). Discussions and conclusions: The detected values showed that the active component measured by bioimpedance method should achieve almost 90 % of total body mass in junior elite soccer players and 87 % in adolescent players. The detected asymmetry in fluid distribution in the lower limbs is the effect of maladaptation on the specific load of the soccer players.These differences should be taken into account in the training practice and compensated by the adequate exercises.In terms of practice, the results may be beneficial for fitness coaches, nutrition specialist, team medical staff and other clinical staff in professional soccer.
Sparse Autoencoders in Sentiment Analysis

This paper examines the utilization of sparse autoencoders in the task of sentiment analysis. The autoencoders can be used for pre-training a deep neural network, discovering new features or for dimensionality reduction. In this paper, sparse autoencoders were used for parameters initialization in deep neural network. Experiments showed that the accuracy of text classification to a particular sentiment may be improved by incorporating sparse autoencoders to this task. Analysis, outcomes, and description of this approach are presented.
Projection Mapping for a Kinect-Projector System

Spatial augmented reality allows users to create a projected virtual environment on irregular surfaces. This demands an extensive knowledge in the Camera-Projector calibration area. This paper presents a framework developed to facilitate the use of data achieved from a calibration of a Kinect-Projector system in visualization applications. Additionally, different calibration techniques were evaluated in order to demonstrate the better approaches.
Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast

The M3 muscarinic receptor is a prototypical member of the class I family of G protein-coupled receptors (GPCRs). To facilitate studies on the structural mechanisms governing M3 receptor activation, we generated an M3 receptor-expressing yeast strain (Saccharomyces cerevisiae) that requires agonist-dependent M3 receptor activation for cell growth. By using receptor random mutagenesis followed by a genetic screen in yeast, we initially identified a point mutation at the cytoplasmic end of transmembrane domain (TM) VI (Q490L) that led to robust agonist-independent M3 receptor signaling in both yeast and mammalian cells. To explore further the molecular mechanisms by which point mutations can render GPCRs constitutively active, we subjected a region of the Q490L mutant M3 receptor that included TM V–VII to random mutagenesis. We then applied a yeast genetic screen to identify second-site mutations that could suppress the activating effects of the Q490L mutation and restore wild-type receptor-like function to the Q490L mutant receptor. This analysis led to the identification of 12 point mutations that allowed the Q490L mutant receptor to function in a fashion similar to the wild-type receptor. These amino acid substitutions mapped to two distinct regions of the M3 receptor, the exofacial segments of TM V and VI and the cytoplasmic ends of TM V–VII. Strikingly, in the absence of the activating Q490L mutation, all recovered point mutations severely reduced the efficiency of receptor/G protein coupling, indicating that the targeted residues play important roles in receptor activation and/or receptor/G protein coupling. This strategy should be generally applicable to identify sites in GPCRs that are critically involved in receptor function.
Implicit and Explicit Associations in the Fear Structure of Social Anxiety

Implicit associations in the fear structure of social anxiety were investigated and their relations with explicit associations were examined in the present study. The Implicit Association Test was used to assess implicit associations. Individuals scoring High (n = 26) and Low (n = 18) on Social Anxiety completed two forms of the Implicit Association Test and rated the probability and cost of negative social outcomes. Analyses showed an implicit association between anxiety responses and negative evaluations was more strongly formed in the High Social Anxiety group than in the Low Social Anxiety group. Furthermore, relations between implicit associations and explicit measures were minimal. These findings suggested that the Implicit Association Test is suitable for the assessment of implicit associations in the fear structure of social anxiety, and that implicit associations of social anxiety are relatively independent of explicit associations.
A photovoltaic system suitable for the battery pack charging of an electrically power assisted velocipede

The paper describes the designing, sizing, realization and setting up of a complete system suitable for the management of an electrically power assisted velocipede using a photovoltaic module for the charging of the batteries. In the work an overview on the sustainable mobility needs and on the commercial electrically power assisted velocipedes is presented and the "Ecolapa" prototype, set up in the SDELab laboratory of Palermo University, is precisely described underlining the designing, implementation and setting up phases of the photovoltaic charging system settled up on the velocipede. Moreover tests oriented on the setting up of the whole system and validation tests on the prototype are presented with the aim of determine the growing up of performances, with particular attention on the autonomy, by using the management system here proposed. The results show haw is possible to reach an increase of the 30% of the "Ecolapa" prototype autonomy by using the, by the Authors conceived, management system.
Hacia una etnología del megalitismo: usos y memorias de los sitios megalíticos en las poblaciones rurales del sur de Portugal

Apropiandose de los objetos culturales pasados, las sociedades los hacen inteligibles y les dan sentido y uso en determinados contextos historicos, en otras palabras, "domestican" el pasado. A lo largo de los anos, se han construido en torno a los megalitos (entendidos como marcas o lugares donde se fija la memoria) multiples discursos. Estos discursos sobre los testimonios antiguos son fundamentales para comprender como las personas confieren memoria a los lugares del territorio que habitan, construyen representaciones del tiempo y del pasado y definen su identidad
CT-guided transthoracic lung biopsy: Predictive factors of pneumothorax

association has been described with similar results and could be due to a combination of the effects of obesity and diffuse airway obstruction. Obesity is known to be a major risk factor for OSA linked with increased neck circumference and amounts of peripharyngeal fat, which could narrow and compress the upper airway; obesity may also play a role by reducing lung volumes. Obesity affects ERV by decreasing FRC, and ERV may also be reduced with an increase in residual volume (RV) that occurs, not exclusively, but particularly in the obese, due to premature closure of the small peripheral airways. We found that the absolute effect of the correlation of ERV with obstructive events was similar to the effect of BMI, but ERV remained influential independently of all confounders such as BMI. The reduction in end-expiratory lung volumes, which are accentuated in sleep, may lead to a reduction in tracheal traction on the pharynx and so increasing its collapsibility. Conversely, increases in lung volumes have been shown to increase tracheal traction with stabilization of the upper airway during inspiration, and in OSA patients, they have been shown to decrease positive airway pressure requirements and OSA severity, suggesting improvements in pharyngeal collapsibility. Although this relationship seems unequivocal, as shown in our study, more research is needed in order to define more precisely which end-expiratory volume -ERV, FRC or even RV -plays the major role and how it influences the occurrence of obstructive events during sleep. References
Infection with Chlamydia pneumoniae as a cause of coronary heart disease: the hypothesis is still untested.

We are convinced that Chlamydia pneumoniae research has been unfavorably affected by the negative results of antibiotic treatment trials for the secondary prevention of late-stage coronary heart disease (CHD) (O'Connor et al. , 2003; Cannon et al. , 2005; Grayston et al. , 2005). There is a widespread belief that the clinical trials showed that C. pneumoniae has no role in atherosclerotic disease. This flawed causal inference from these trials has contributed to slowing much-needed research on C. pneumoniae. It has also resulted in a nearly complete loss of momentum for research on the infection-based response to injury hypothesis as a key factor in the initiation and progression of CHD. ### Box 1 Chlamydia pneumoniae had been considered a possible cause of atherosclerosis. That antibiotics failed to prevent secondary coronary events in patients with established coronary artery disease has been erroneously interpreted as ruling out a causative role for C. pneumoniae . This misinterpretation has had a chilling effect on C. pneumoniae research. Our concern has been confirmed by the sharp drop in published reports (PubMed citations) on C. pneumoniae since 2005. From 1999 to 2005, approximately 375 papers were published each year. There has been a 62% drop from that number with 143 being listed for 2013. The antibiotic treatment trials were not etiologic studies. No inference regarding the role of C. pneumoniae in the cause of atherosclerosis can properly be made from the trials. A prior publication stated that the study design for these trials precluded proving or disproving a role for C. pneumoniae in the initiation or progression of atherosclerosis, and predicted an overreaction to either negative or positive results (Grayston 2000). All subjects of these trials had established coronary artery disease with mostly advanced disease. Most had had a myocardial infarction (MI). The trials studied whether antibiotics could prevent …
Closed sequential tests for binomial probabilities.

A statistical test based on a sequence of observations is termed closed if an upper bound, say n, is placed on the length of the sequence. In the case of Bernoulli trials several such tests have been constructed by solving a related problem in the theory of random walk with an absorbing barrier (Spicer, 1962), by modifying statistical procedures based on an infinite sequence of observations (Wald, 1947; Armitage, 1957), or by empirical methods (Bross, 1952). As each of these procedures tends to be less powerful than the optimal test based on the entire series of n observations, a sequential version (Alling, 1963, ? 4.3) of the latter type of test is of interest and will be described in this note. The proposed test, as might be anticipated, tends to be less economical in the use of observations than the closed sequential procedures currently being employed.
Primary Cilia Integrate Hedgehog and Wnt Signaling during Tooth Development

Many ciliopathies have clinical features that include tooth malformations but how these defects come about is not clear. Here we show that genetic deletion of the motor protein Kif3a in dental mesenchyme results in an arrest in odontogenesis. Incisors are completely missing, and molars are enlarged in Wnt1Cre+Kif3afl/fl embryos. Although amelogenesis and dentinogenesis initiate in the molar tooth bud, both processes terminate prematurely. We demonstrate that loss of Kif3a in dental mesenchyme results in loss of Hedgehog signaling and gain of Wnt signaling in this same tissue. The defective dental mesenchyme then aberrantly signals to the dental epithelia, which prompts an up-regulation in the Hedgehog and Wnt responses in the epithelia and leads to multiple attempts at invagination and an expanded enamel organ. Thus, the primary cilium integrates Hedgehog and Wnt signaling between dental epithelia and mesenchyme, and this cilia-dependent integration is required for proper tooth development.
Isomer-Specific Bioactivation and Toxicity of Dichlorophenyl Methylsulphone in Rat Olfactory Mucosa

This study aimed to explain the isomer- and site-specific toxic effects of dichlorophenyl methylsulphone in the olfactory mucosa of rats. A single ip dose of the 2,6-chlorinated isomer (16 or 65 mg/kg) induced necrosis preferentially in the Bowman's glands and neuroepithelium in the dorsomedial part of the olfactory region. Only minor damage occurred at this site in rats dosed with the 2,5-chlorinated isomer (65 mg/kg). A strong concentration-and time-dependent covalent binding of the 14C-labeled 2,6-isomer to rat olfactory microsomes was demonstrated. In contrast, no significant covalent binding of the 14C-labeled 2,5-isomer was observed. The cytochrome P450 (CYP) inhibitors metyrapone, tranylcypromine and acetonitrile inhibited covalent binding of the 2,6-isomer to olfactory microsomes. Glutathione (GSH) appeared to play a protective role as a scavenger of a reactive intermediate whereas methyl-GSH did not alter covalent binding to olfactory microsomes. As determined by microautoradiography, binding of the 2,6-chlorinated isomer in the olfactory mucosa was confined to the Bowman's glands. Both isomers showed a low binding to liver microsomes and caused no liver injury. We suggest that a CYP2A-catalyzed activation of the 2,6-chlorinated dichlorophenyl methylsulphone to a reactive intermediate and adduct formation in the Bowman's glands will initiate a site-specific toxicity of this isomer in the olfactory mucosa.
Play It Again, Sam Weller: New Digital Audiobooks and Old Ways of Reading

�� ��� Ahem. The speaker is about to read aloud Nancy’s murder, a brutal tableau from Oliver Twist (1837–39) ritually performed before the public since Dickens’ first recitation of this scene at St. James’s Hall as part of a Farewell Tour in 1869. The ‘Murder’, as the author preferred to call it, would soon become part of Dickens lore for the violence with which it ended the life not only of the novel’s heroine but also of the novelist himself. 1 The ‘Sikes and Nancy’ episode begins with the narrator’s voice as one of the boy thieves is instructed to ‘dodge’ a young woman through the streets of London. The ensuing voices are those of Fagin (‘my dear’), Bolter (‘Oh Lor! ’), and Sikes (‘Wot now? ’), whose Cockney accents are performed in markedly different registers from that of the preceding narrator. 2 In fact, each of the characters is set apart by a distinct sound to ensure that audiences can tell who is speaking without access to the written script. The prompt copy used by Dickens for this scene signals the building momentum toward Sikes’ terrible act of violence with the marginal stage direction ‘XX Murder coming XX’. 3 This is the moment during the recitation when Dickens was said by spectators to have flung aside the script in order to perform the scene from memory. 4 The audience for the performance has little choice but to sit back and wait for the impending murder since the pace of narration is controlled entirely by the speaker, not the auditor. It is a tense wait. The recitation of a scene that takes a mere ten minutes to read silently to one’s self can take upwards of forty minutes when read aloud before an audience. Although both experiences might make the flesh creep, reading the novel in silence is a very different experience from that of listening to Nancy’s murder. Now that Nancy’s murder has caught your ear, let me assure you that this is not another account from an ear-witness to one of the nearly 500 public readings given by Dickens to audiences across England and America. 5 There is no lectern, maroon backcloth, or blaze of gaslamps
Current Management of Colorectal Cancer with Liver Metastasis

Colorectal cancer is a worldwide public health problem. More than 20% of patients with colorectal cancer present at an advanced stage, and the liver is the most common site of metastases. More recently, selection criteria for resectability have been expanded, but definition of resectability still remains challenging. Since the presence of metastases is the most relevant prognostic factor, surgical resection of liver metastases is the mainstay of treatment. The most appropriate resection approach remains controversial, but both staged and simultaneous resection has been shown to have comparable survival advantages and long-term outcomes. The advent of new chemotherapeutic agents and the development of loco-regional therapies (embolization, ablation, and infusion chemotherapy) have contributed to better outcomes. It is deemed reasonable to adopt combination therapy for unresectable metastases. In view of the lack of standardized evidence-based protocols, optimal management of hepatic metastases should be individualized to the single patient and decided through a multidisciplinary approach. Early detection is always the ultimate goal to reduce metastatic colorectal cancer burden worldwide. In this overview, the current management of liver metastases originating from colorectal cancer is presented.
Novel methods and approaches to acute lymphoblastic leukemia drug discovery

Introduction: Acute lymphoblastic leukemia (ALL) is a significant cause of cancer-related morbidity and mortality. Major advances in the understanding of the pathogenesis of ALL have uncovered new disease-associated biomarkers that can be targeted by biological and small-molecule therapeutics. Areas covered: In this review, the authors examine novel approaches to target and drug discovery in ALL over the past 10 years. Cell surface antigens can be targeted by engineered mAbs and chimeric antigen receptor T cells. Detailed mechanistic studies in Philadelphia chromosome-positive ALL and ALL with mixed lineage leukemia rearrangements highlight current molecular approaches to target and drug discovery. Genomic technologies have uncovered genetic alterations that are potentially targetable. In addition, phenotypic screening can uncover unexpected targets. New targets in ALL include cell surface antigens, kinases, tumor suppressors, transcription factors, epigenetic regulators and metabolic enzymes. Expert opinion: There are a number of effective approaches for discovering novel targets in ALL. Target validation is essential for further development of new therapeutics. Identifying select patient subsets with specific genetic vulnerabilities will be important in moving these therapeutics forward clinically.