Miracle-dz/UniFAR-FTUs huggingface dataset:
In-Vitro Antibacterial Activity of Lantana trifolia Flower Extracts on Bacterial Isolates from Wounds AGWU, EJ

This study investigated the phytochemical constituents and antibacterial activities of Lantana trifolia flower extracts against bacterial isolates from surgical and diabetic wounds of patients. Phytochemical investigation was done by standard procedure, antimicrobial screening by agar well diffusion method and antibiotics susceptibility of isolates by Kirby-Bauer disc diffusion test. Phytochemicals present include flavonoids, tannins, phenylethanoid glycosides, reducing sugars, terpenoids, saponins, anthraquinones alkaloids and steroids. Bacterial wound isolates were mainly gram +ve and include Staphylococcus aureus, S. epidermidis, Enterococcus faecalis, Corynebacterium sp. , Enterobacter aerogenes, Pseudomonas aeruginosa, Mycobacterium sp. and Escherichia coli. Inhibition diameter was concentration. The range of inhibition diameter was significantly (P<0.05) lower in the aqueous extract (15.2±1.5 to 35.5 ±0.9 mm) than the ethanolic (28.3± 3.4 to 49.1±8.9mm). Antibacterial activity occurred at very low concentrations (18.75mg/ml) for ethanolic extract only. The most L trifolia extract sensitive bacterial isolate was S. aureus (35.5±0.9mm and 49.1±8.9mm for aqueous and ethanolic extracts respectively at 300mg/ml), while the least sensitive were Corynebacterium sp. (15.2±1.5mm) and Mycobacterium sp. (28.3±3.4) at 300mg/ml for aqueous and ethanolic extracts respectively. The minimum inhibitory concentration was lower for ethanolic extract, 18.75/ml to 37.5mg/ml than the aqueous extract (37.5 to 150mg/ml). The minimum bacterial concentration range from 37.5mg/ml to 150mg/ml for ethanolic extract and 75 to 300mg/ml for aqueous extract. S. aureus was the most antibiotic resistant strain (72%), while P. aeruginosa and Mycobacterium sp. were the least resistant (9.1%) strains. L. trifolia was more bacteriostatic than the most effective antibiotics, Ciprofloxacin, Rocephin, Nitrofurantoin, and deserves further investigation. DOI: https://dx.doi. org/10.4314/jasem.v23i8. 20 Copyright: Copyright © 2019 Agwu. This is an open access article distributed under the Creative Commons Attribution License (CCL), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Dates: Received: 09 July 2019; Revised: 18 August 2019; 24 August 2019
Semi-Autonomous Coordinate Configuration Technology of Base Stations in Indoor Positioning System Based on UWB

In the global positioning system (GPS) denied environment, an indoor positioning system based on ultra-wide band (UWB) technology has been utilized for target location and navigation. It can provide a more accurate positioning measurement than those based on received signal strength (RSS). Although promising, it suffers from some shortcomings that base stations should be preinstalled to obtain reference coordinate information, just as navigation satellites in the GPS system. In order to improve the positioning accuracy, a large number of base stations should be preinstalled and assigned coordinates in the large-scale network. However, the coordinate setup process of the base stations is cumbersome, time consuming, and laborious. For a class of linear network topology, a semi-autonomous coordinate configuration technology of base stations is designed, which refers to three conceptions of segmentation, virtual triangle, and bidirectional calculation. It consists of two stages in every segment: Forward and backward. In the forward stage, it utilizes the manual coordinate setup method to deal with the foremost two base stations, and then the remaining base stations autonomously calculate their coordinates by building the virtual triangle train. In the backward stage, the reverse operation is performed, but the foremost two base stations of the next segment should be used as the head. In the last segment, the last two base stations should be used as the head. Integrating forward and backward data, the base stations could improve their location accuracy. It is shown that our algorithm is feasible and practical in simulation results and can dramatically reduce the system configuration time. In addition, the error and maximum base station number for one segment caused by our algorithm are discussed theoretically.
Bias Analysis of Parameter Estimator Based on Gauss-Newton Method Applied to Ultra-Wideband Positioning

Chuanyang Wang 1,2 , Hang Yu 1,2, Jian Wang 3,* and Tianjun Liu 4 1 NASG Key Laboratory for Land Environment and Disaster Monitoring, China University of Mining and Technology (CUMT), Xuzhou 221116, China; wangchuanyang@cumt.edu. cn (C.W.); yhecit@cumt.edu. cn (H.Y.) 2 School of Environment Science and Spatial Informatics, China University of Mining and Technology (CUMT), Xuzhou 221116, China 3 School of Geomatics and Urban Information, Beijing University of Civil Engineering and Architecture (BUCEA), Beijing 100044, China 4 GNSS Research Center, Wuhan University (WHU), Wuhan 430079, China; viper_tjliu@whu.edu. cn * Correspondence: wangjian@bucea.edu. cn; Tel. : +86-150-5084-1419
The Effects of Posterior Talar Glide and Dorsiflexion of the Ankle Plus Mobilization with Movement on Balance and Gait Function in Patient with Chronic Stroke: A Randomized Controlled Trial

© 2018 Journal of Neurosciences in Rural Practice | Published by Wolters Kluwer Medknow Background: This study was to evaluate the effects of weight‐bearing‐based mobilization with movement (WBBMWM) on balance and gait in stroke patients. Methods: Thirty stroke patients participated in this study. All individuals were randomly assigned to either WBMWM group (n = 15) or weight‐bearing with placebo mobilization with movement group (control, n = 15). Individuals in the WBMWM group were trained for 10 glides of 5 sets a day, 5 times a week during 4 weeks. Furthermore, individuals in the control group were trained for 10 lunges of 5 sets a day, 5 times a week during 4 weeks. All individuals were measured weight‐bearing lunge test (WBLT), static balance ability, timed up and go test (TUG), and dynamic gait index (DGI) in before and after intervention. Results: The result showed that WBBMWM group and control group had significantly increased in WBLT, postural sway speed, total postural sway path length with eyes open and closed, TUG and DGI (P < 0.05). In particular, the WBMWM group showed significantly greater improvement than control group in WBLT, static balance measures, TUG, and DGI (P < 0.05). Conclusion: Therefore, WBMWM improved ankle range of motion, balance, and gait in stroke patients. These results suggest that WBBMWM is feasible and suitable for individuals with a stroke.
W REGULARIZING EFFECT IN A NONLINEAR, DEGENERATE PARABOLIC EQUATION IN ONE SPACE DIMENSION

In this paper we provide and analyze a nonlinear degenerate parabolic equation in one space dimension with the following smoothing property: If the initial data is only uniformly continuous, at positive times, the solution has bounded second derivatives (it belongs to W 2 ; 1 ). We call this surprising phenomenon a W 2 ; 1 regularizing e(cid:11)ect. So far, such phenomena have only been observed in uniformly parabolic equations.
Impact of El Niño and El Niño Modoki Events on Indonesian Rainfall

On an interannual time-scale, the Indonesian climate is strongly influenced by the dynamics of Indo-Pacific climate modes. This study aims to investigate the possible impact of different types of El Niño events, namely, typical El Niño and El Niño Modoki, on Indonesian rainfall variability. Seasonal composite analysis was used to evaluate the magnitude and significance level of the influence of El Niño on the rainfall variability over the Indonesian region. Typical El Niño (hereafter El Niño) has a stronger influence on Indonesian rainfall than the El Niño Modoki during boreal autumn in September, October, and November when the events almost reach their peak. Cold sea surface temperature (SST) anomalies were observed in the Indonesian sea and in the western Pacific during El Niño years, while cold SST anomalies covered only the eastern Indonesian sea during El Niño Modoki years. Strong cold SST anomalies during El Niño years led to stronger low-level wind divergence over the Maritime Continent compared with that during El Niño Modoki years. In addition, the Walker circulation during El Niño years revealed a stronger downward motion over the Maritime Continent than that observed during El Niño Modoki years. This stronger downward motion (low-level wind divergence) during El Niño years reduced lower atmospheric water vapor and suppressed atmospheric convection over the Maritime Continent, leading to a significant decrease in rainfall. Similar situations were also observed during El Niño Modoki years but with a much weaker amplitude.
Pitambar Gautam.pmd

Magnetic fabric data based on the anisotropy of magnetic susceptibility (AMS) of the sediments constituting the Siwalik sections (Karnali R., Amilia–Tui Road, Surai R., Tinau R., and Rato R.) in Nepal have been analysed for the variability of magnetic lineation and the implications to the time-space evolution of the stress field in this region during the last 16 myrs. This involved compilation of (i) the magnetic polarity data that constrain the depositional age of the Nepalese Siwaliks to ca. 16 to 1 Ma, and (ii) the declination of characteristic magnetic remanence to reveal the relative tectonic rotations (17° CCW at Butwal to 9° CW at Amilia). The magnetic fabric, defined mainly by alignment of paramagnetic minerals, corresponds to an oblate ellipsoid with foliation parallel to bedding plane, implying a sedimentary-compactional origin. The magnetic lineations show well defined clusters (confined in or close to the bedding plane). Being subparallel to the fold axes/bedding strikes/thrust fronts, these lineations are assumed to originate from a secondary mild deformation process related to the compression tectonics in the Siwalik foredeep and therefore correspond to the active direction of the minimum principal horizontal stress active during foredeep deposition. Hence, the direction of compression is orthogonal to the mean lineation. The compression direction in the palaeogeographic coordinates can be obtained by introducing an additional correction for the tectonic rotation about the vertical, using the palaeomagnetic declination. Available AMS-based lineations, corrected for rotation about vertical using palaeomagnetic declinations, reveal that the compression direction in the Himalayan foreland remained in general N to NNE with significant deviations in its far western part, in particular around the Amilia–Tui section where the direction was N58oE.
Effect of Mefenamic Acid on Some of The Base Excision Repair Enzymes Against D-Serine-Induced Neurotoxicity

N-methyl-D-aspartate receptor (NMDAR) overactivation leads to free radical production, protein degradation, lipid peroxidation and DNA damage. Recently, nonsteroidal antiinflammatory drugs (NSAIDs) are suggested to be good candidates for the treatment of neurological insults. In this study, we aimed to evaluate the effect of mefenamic acid on 8-OHdG levels, the expression of poly(ADP ribose) polymerase-1 (PARP-1) and base excision repair (BER) enzymes; 8-oxoguanine DNA glycosylase 1 (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1) against D-serine. Adult Sprague-Dawley rats were divided into four groups: (i) the control (n=6); (ii) D-serine (n=6); (iii) Mefenamic acid (n=6); (iv) D-serine+Mefenamic acid (n=6). Rats were decapitated 6 hours after the injections. The mRNA and protein expression levels were determined by real-time PCR and western blot techniques, respectively. D-serine increased APE1 mRNA, PARP-1 mRNA and 8-OHdG levels. APE1 and PARP-1 genes were significantly upregulated by mefenamic acid. Protein expression profiles were also consistent with mRNA levels. However neither mRNA nor protein levels of OGG1 were affected by D-serine or mefenamic acid. Our results suggest that NMDA/D-serine signaling triggers DNA repair mechanisms and oxidative DNA damage simultaneously. We may conclude that mefenamic acid have a potential neuroprotective effect and assist to repair NMDAR-mediated DNA damage via modulating DNA repair mechanisms.
A numerical framework for simulation of swirled adhesive application

A numerical framework for simulation of swirled adhesive application along arbitrary robot motions and substrate geometries is pre- sented. The momentum and continuity equa- tions are solved on a Cartesian octree grid using a finite volume discretization. A viscoelastic constitutive model is used to describe the com- plex rheology of the adhesive and is solved us- ing a previously presented Lagrangian-Eulerian method. The flow from the nozzle to the target surface is modelled using experimental data, and a projected injection model is used to add adhesive material in the simulation close to the surface. The two-phase flow of adhesive and air is then simulated. Numerical results are com- pared with experimental data and good agree- ment is found.
Thunderstorm ground enhancements (TGEs) abruptly terminated by negative cloud-to-ground lightnings

The relationship of lightnings and particle fluxes in the thunderclouds is not fully understood to date. Using the particle beams (the so-called Thunderstorm Ground Enhancements – TGEs) generated in the lower part of clouds by the strong electric fields as a probe, we investigate the characteristics of the related atmospheric discharges. The well-known effect of the TGE dynamics is the abrupt termination of the particle flux. We demonstrate that among 12 atmospheric discharges that abruptly terminated TGE all are the negative cloud-to-ground lightnings. The flux termination and lightning occurred at one and the same second. With new precise electronics on millisecond time scales we can see that particle flux decline occurred simultaneously with abrupt increase of electrostatic field after the return stroke of the lightning. Therefore, the declining of particle flux is connected with rearranging of charge centers in the cloud involving removal of the Lower Positive Charged Region (LPCR).
Nash Tracking Game with Preview by State Feedback for Linear Continuous-Time Markovian Jump Systems

In this paper, we study Nash tracking problems for linear continuous-time Markovian jump systems over finite time intervals. We introduce double coupled differential equatuons (CDREs) to give solutions of the tracking problems with multi-players. Corresponding to the double coupled properties of the CDREs, the forms of preview compensator dynamics are double coupled. In this paper, we focus on the derivation of the necessary conditions for the solvability of the tracking problems by variational approach.
Regulation of LRRK2 activation, localization and dimerization

Leucine-rich-repeat kinase 2 (LRRK2) is a large multi domain protein with two enzymatic functions: kinase and GTPase activity. Mutations in LRRK2 are accounting for the majority of genetically inherited Parkinson’s Disease. Many LRRK2 mediated pathways and interaction partners have been identified, however the cellular functions of LRRK2 and LRRK2 mediated progression of PD are still not completely understood. PD-linked mutations in LRRK2 are found in nearly every domain. Importantly, most of these mutations have been linked to increased kinase and/or reduced GTPase activity. Accumulating data suggest that LRRK2 has a complex activation mechanism, involving multiple layers of regulation. Here we highlight the recent data available on LRRK2 intramolecular signaling, dimerization and protein-protein interactions and discuss how these processes together regulate LRRK2 signaling and affect LRRK2-mediated PD.
The long non-coding RNA H19 promotes invasion and metastasis of ovarian cancer cell through EMT-related protein regulation

The long non-coding RNA (lncRNA) H19 is reported to be involved in invasion and metastasis of ovarian cancer (OC). In addition, the epithelial-mesenchymal transition (EMT) plays a role in the progression and metastasis of OC. However, whether lncRNA H19 involvement in OC invasion and metastasis is associated with EMT remains unclear. Eight cases of OC tissues and the corresponding adjacent normal (AN) tissues were included. The expressions of lncRNA H19 and EMT-related proteins (E-cadherin, TWIST1, Slug, and Snail) were detected by RT-qPCR and immunohistochemistry. Human OC cell lines (SKOv3, OVCAR3, CoC1, A2780, and HO-8910PM) and human normal ovarian surface epithelial HOSEpiC cells were obtained from ATCC. SKOv3 cells that silence the lncRNA H19 expression (silncRNA H19) were established via a transfection of recombinant lentivirus. The expression of lncRNA H19 and EMT-related proteins were significantly increased in human OC tissues compared with relative AN tissues (except for a decline in the level of E-cadherin) assessed through RT-qPCR and western blot. The lncRNA H19 and both EMT-related protein and mRNA levels (TWIST1, Slug, and Snail) in OC cell lines including SKOv3, OVCAR3, CoC1, A2780, and HO-8910PM were dramatically elevated compared with HOSEpiC cells (SKOv3 and OVCAR3: P < 0.01; CoC1, A2780, and HO-8910PM: P < 0.05); however, the expression of E-cadherin protein and mRNA were decreased, which is consistent with the results in vivo. Inhibition of lncRNA H19 expression in SKOv3 cells abolished the effects of lncRNA H19 on EMT-associated protein regulation. Importantly, Transwell assay suggested that invasion and metastasis ability were significantly reduced in SKOv3+silncRNA H19 group compared with SKOv3 group (P < 0.01). This study demonstrates a novel mechanism by which lncRNA H19 modulates OC cell invasion and metastasis, and this mechanism is involved in the regulation of EMT-related proteins.
The protective Role Of Honey-Bee Products Against The Genotoxic Effects Of Cyclophosphamide in Male Mice

The protective effects of honey-bee products (HP) (1 gm/kg.b.w) against genotoxicity induced by Cyclophosphamide (CP) were investigated in mice. 20 mg/kg.w. of cyclophosphamide were dissolved in 150 ul (high concentration dose, CP1) or in 300 ul (low concentration dose, CP2) of sterilized distilled water. Then, high dose (CP1)/animal or low dose (CP2)/animal were used and injected intraperitoneally. The HP treatments were assessed at the same time of CP injection or two weeks before using CP treatment. CP treatment induced significant increases of chromosome aberrations, DNA fragmentation and spermshape abnormalities as well as a significant depression of mitotic activity as compared to control group. Also, CP injection revealed a marked damaging effect on liver tissues. CP in a high dose caused severe damages of genetic, sperm and histological parameters as compared to low dose. The treatment with HP at the same time of injection of CP (CP1 HP or CP2 HP groups) or two weeks before using CP (HP CP1 or HP CP2 groups) significantly ameliorated the genetic, sperm and histological parameters as compared to the treatment with CP alone. However, the best protective effect was observed by using the HP treatments at the same time with CP injection, where, more improvements of genetic materials and sperm morphology as well as more normalization of liver tissues occurred in CP1 HP or CP2 HP groups than those observed in HPCP1 or HPCP2 groups. The results of most genetic and sperm examinations, except some histological measurements showed that there were no significant differences between the protective effect of HP against high dose (CP1) of CP and the protective role of HP against low dose (CP2) of CP, suggesting the potent antimutagenic activity of the HP. In conclusion, the present study demonstrated that side dangerous effect of anti-cancer drug CP could be avoided by using the treatment of honey-bee products especially at the same time with CP injection. This strategy is necessary for diminishing the deleterious side effects of anti-cancer drug with preservation of its chemotherapeutic efficacy.
Cloning ， Homology Analysis ， and Distribution of Neural Development Ｒe-lated Genes of Chinese Ｒare Minnow ( Gobiocypris rarus )

: The poverty in knowledge of neurodevelopment of Chinese rare minnow ( Gobiocypris rarus ) limited its ap-plication as a native model fish in neurotoxicital studies and risk assessment． In this case ， partial of nerve growth factor ( ngf ) ， brain-derived neurotrophic factor ( bdnf ) ， glial fibrillary acidic protein ( gfap ) ， myelin-associated glycoprotein ( mag ) ， myelin protein zero ( mpz ) ， α 1-tubulin and SＲY-box containing gene 10 ( sox10 ) were cloned from brain of rare minnow ， and their sequences and transcriptional profile were also studied． Blasting results demonstrated that the sequences of gfap ， ngf ， mag and α 1-tubulin in rare minnow shared the highest identities with those of zebrafish ( Danio rerio ) ( 95% ， 92% ， 92% and 96% ， respectively ) ． bdnf gene shared the highest homology with the nucleotide sequence of Carassius auratus and Cyprinus carpio ( 98% ) ， whereas mpz and sox10 were more homoge-nous with the nucleotide sequence of Pimephales promelas ( 94% ) and Hypophthalmichthys nobilis ( 97% ) respec-tively． Besides ， the transcriptional profile revealed highest abundance of ngf ， bdnf ， mag ， mpz ， α 1-tubulin and sox10 mＲNA in the brain and of gfap in the spinal cord of Chinese rare minnow． These results provided a foundation for fu-ture studies in neurodevelopment and neurotoxicity assessment using rare minnow as a native model fish．
Alternative Labor Market Policies to Increase Economic Self-Sufficiency: Mandating Higher Wages, Subsidizing Employment, and Increasing Productivity

I review evidence on alternative labor market policies that could potentially improve economic self-sufficiency via mandating higher wages, subsidizing employment, or increasing productivity. The evidence indicates that the minimum wage is an ineffective policy to promote economic self-sufficiency, entailing employment losses without any corresponding distributional benefits via higher wages. In contrast, living wage laws appear to present a more favorable tradeoff. Labor supply incentives, in particular the EITC, appear effective, as a more generous EITC boosts employment of single mothers and in so doing raises incomes and earnings of low-income families. There is some evidence that wage subsidies increase employment and earnings, but problems of stigmatization resulting from eligibility for wage subsidy programs can dissipate the gains, and wage subsidies entail substantial administrative difficulties. Finally, a newer but growing literature on school-to-work provides some evidence that school-to-work programs boost labor market attachment, skill formation, wages, and earnings.
High frequency and high efficiency DC-DC converter with sensorless adaptive-sizing technique

A high frequency and high efficiency DC-DC converter with sensorless adaptive-sizing technique is proposed. Instead of conventional adaptive-sizing technique with current sensor, the proposed converter estimates the load current according to the output voltage of error amplifier for switch scaling. The elimination of current sensor reduces power consumption, thus improving efficiency further. This design is validated through simulation in a 0.18 μm CMOS process. At switching frequency of 150MHz and light-load of 20mA, the proposed converter achieves a high efficiency of 82.4%, while it is 73.7% with conventional adaptivesizing technique, and 62.4% without adaptive-sizing technique.