Miracle-dz/UniFAR-FTUs huggingface dataset:
RECONSTRUÇÃO ÓSSEA HORIZONTAL COM rhBMP-2 E BLOCO XENÓGENO; HORIZONTAL BONE RECONSTRUCTION WITH rhBMP-2 AND XENOGEN BLOCK

A utilizacao de implantes dentarios no tratamento de pacientes total ou parcialmente desdentados tem se tornado uma modalidade de tratamento comum e bem aceita. Nao obstante, os pacientes indicados para instalacao de implantes dentarios, apresentam ausencia de disponibilidade ossea e o uso de enxertos alogenos, xenogenos e materiais aloplasticos evitam os problemas relativos a morbidade e disponibilidade quando comparados aos enxertos osseos autogenos, mas nao proveem sinais de osteoinducao e celulas osteogenicas. O presente artigo objetiva apresentar um relato de caso de uma reabilitacao oral de uma paciente parcialmente desdentada de 58 anos de idade, que apresentou um defeito osseo tridimensional amplo requerendo um enxerto osseo onlay, para restabelecimento da arquitetura ossea. Desse modo, ratifica-se que a utilizacao de fatores de crescimento osseo como o rhBMP-2 potencializa a resposta celular e otimiza os resultados de ganho osseo em areas enxertadas, especialmente quando da utilizacao de enxertos osseos xenogenos, a associacao desses dispositivos com diferentes propriedades que vem a se complementar atenua o uso de blocos de enxerto autogeno e consequentemente a morbidade cirurgica oriunda dessa tecnica.
UJI BIOAKTIVITAS EKSTRAK TERIPANG KELING Holothuria atra SEBAGAI ANTIBAKTERI Staphylococcus aureus dan Escherichia coli

Teripang keling Holothuria atra merupakan salah satu jenis teripang yang memiliki kandungan senyawa bioaktif seperti flavonoid, fenol, saponin, dan alkaloid yang berpotensi sebagai senyawa antibakteri. Bakteri S. aureus dan E. coli merupakan bakteri patogen yang dapat menyebabkan kerusakan pada bahan pangan dan menyebabkan penyakit pada manusia, sehingga diperlukan senyawa antibakteri alami sebagai alternatif pengganti antibakteri sintetis untuk menghambat pertumbuhan bakteri patogen tersebut. Tujuan penelitian ini untuk mengetahui kandungan senyawa bioaktif ekstrak teripang H. atra dengan pelarut etil asetat, n-heksan, dan etanol, pengaruh perbedaan konsentrasi ekstrak teripang terhadap zona hambat bakteri S. aureus dan E. coli, serta potensi teripang sebagai antibakteri alami. Metode yang digunakan dalam penelitian adalah eksperimental laboratoris dengan Rancangan Acak Lengkap (RAL). Parameter pengujian yang dilakukan adalah rendemen, uji fitokimia kuantitatif ekstrak teripang H. atra dengan pelarut n-heksan, etil asetat, dan etanol, uji kontrol positif Kloramfenikol, dan uji zona hambat ekstrak teripang H. atra menggunakan metode kertas cakram dengan konsentrasi 2,5%; 5%; dan 7,5% dengan tiga kali ulangan. Data diameter zona hambat dianalisis menggunakan uji ANOVA dan Beda Nyata Jujur (BNJ). Hasil perhitungan rendemen terbanyak terdapat pada pelarut etanol yaitu 4,43%. Hasil uji fitokimia kuantitatif ekstrak teripang H. atra terbaik didapatkan pada senyawa flavonoid pelarut etanol yaitu 0,65±0,006, sedangkan hasil terendah didapatkan pada senyawa alkaloid pelarut n-heksan yaitu 0,15±0,069, sedangkan hasil zona hambat terhadap bakteri S. aureus dan E. coli diperoleh diameter berkisar antara 3,32 mm – 6,98 mm dan 2,40 mm – 5,93 mm. Berdasarkan hasil penelitian menunjukkan bahwa konsentrasi ekstrak teripang H. atra berpengaruh nyata (P < 5%) terhadap diameter yang terbentuk.
InterLig: a fast and accurate software for ligand-based virtual screening

In the past few years, drug discovery processes have been relying more and more on computational methods to sift out the most promising molecules before time and resources are spent to test them in experimental settings. Whenever the protein target of a given disease is not known, it becomes fundamental to have accurate methods for ligand-based Virtual Screening, which compare known active molecules against vast libraries of candidate compounds. Recently, 3D-based similarity methods have been developed that are capable of scaffold-hopping and to superimpose matching molecules. Here, we present InterLig, a new method for the comparison and superposition of small molecules based on 3D, topologically-independent alignments of atoms. We test InterLig on a standard benchmark and show that it compares favorably to the best currently available 3D methods. InterLig is open source and is available to everyone at: http://wallnerlab.org/interlig.
Greenhouse gas mitigation potential in crop production with biochar soil amendment—a carbon footprint assessment for cross‐site field experiments from China

Biochar soil amendment (BSA) had been advocated as a promising approach to mitigate greenhouse gas (GHG) emissions in agriculture. However, the net GHG mitigation potential of BSA remained unquantified with regard to the manufacturing process and field application. Carbon footprint (CF) was employed to assess the mitigating potential of BSA by estimating all the direct and indirect GHG emissions in the full life cycles of crop production including production and field application of biochar. Data were obtained from 7 sites (4 sites for paddy rice production and 3 sites for maize production) under a single BSA at 20 t/ha−1 across mainland China. Considering soil organic carbon (SOC) sequestration and GHG emission reduction from syngas recycling, BSA reduced the CFs by 20.37–41.29 t carbon dioxide equivalent ha−1 (CO2‐eq ha−1) and 28.58–39.49 t CO2‐eq ha−1 for paddy rice and maize production, respectively, compared to no biochar application. Without considering SOC sequestration and syngas recycling, the net CF change by BSA was in a range of −25.06 to 9.82 t CO2‐eq ha−1 and −20.07 to 5.95 t CO2‐eq ha−1 for paddy rice and maize production, respectively, over no biochar application. As the largest contributors among the others, syngas recycling in the process of biochar manufacture contributed by 47% to total CF reductions under BSA for rice cultivation while SOC sequestration contributed by 57% for maize cultivation. There was a large variability of the CF reductions across the studied sites whether in paddy rice or maize production, due likely to the difference in GHG emission reductions and SOC increments under BSA across the sites. This study emphasized that SOC sequestration should be taken into account the CF calculation of BSA. Improved biochar manufacturing technique could achieve a remarkable carbon sink by recycling the biogas for traditional fossil‐fuel replacement.
Al-Furat Journal of Innovation in Electronics and Computer Engineeing (FJIECE)

A dual bands circular slot based on a substrate integrated waveguide (SIW) antenna is presented in this paper for K-band applications. The proposed antenna structure is consisting of a microstrip antenna with two circular-shape slots etched on the top of radiation plane and located one on top of the other for bandwidth enhancement. This antenna has been printed on an FR-4 substrate with a dielectric constant 4.3 of and thickness of 1.5 mm. The optimized antenna resonates at 22.45 GHZ and 25GHZ with a fractional bandwidth of 1.20 GHZ about (5.353 %) and 1.50 GHZ about (5.994 %), respectively. The achieved peak gain is about 6.14 dB and 4.72 dB over the operating frequencies, respectively, this makes it suitable for K applications with good matching and return loss characteristics. Design model and performance evaluation of a proposed antenna has been executed by EM simulator, CST Microwave Studio. Keywords— dual bands, Microstrip, substrate integrated waveguide SIW, K-band.
The Effect of Curcumin as An Antioxidant on Cochlea Fibroblasts in Ototoxic Rat Models

Aminoglycosides (e.g. Gentamicin) are ototoxic drugs and widely prescribed due to their effective antimicrobial actions and affordable prices. This study focused on determining protective effect of curcumin against the damage caused by aminoglycosides. We aimed to demonstrate the potential of curcumin as an antioxidant to increase the expressions of superoxide dismutase (SOD) in fibroblasts of cochlea lateral wall in ototoxic rat models. The experiment was conducted with randomized post test-only control group design by using 32 male Rattusnorvegicus adults which received a combination of gentamicin and curcumin with different durations and doses. Then, the rats underwent terminations and immunohistochemical assay to determine the expression of SOD. The rats receiving gentamicin injection showed significantly decreased expression of SOD ( P<0.05), and the administration of curcumin before and after the gentamicin injection showed significantly increased expression of SOD (P<0.05). Collectively, we showed that curcumin was an antioxidant against oxidative stress due to ototoxicity evidenced by the expression of SOD.
Emergence of Southern Hemisphere circulation changes in response to ozone recovery

<p>Ozone depletion in the Southern Hemisphere (SH) stratosphere in the late 20<sup>th</sup> century cooled the air there, strengthening the SH stratospheric westerly winds near 60&#186;S and altering SH surface climate. Since ~1999, trends in Antarctic ozone have begun to recover, exhibiting a flattening followed by a sign reversal in response to decreases in stratospheric chlorine concentration due to the Montreal Protocol, an international treaty banning the production and consumption of ozone-depleting substances. Here we show that the post&#8211;1999 increase in ozone has resulted in thermal and circulation changes of opposite sign to those that resulted from stratospheric ozone losses, including a warming of the SH polar lower stratosphere and a weakening of the SH stratospheric polar vortex. &#160; Further, these altered trends extend to the upper troposphere, albeit of smaller magnitudes. &#160;Observed post&#8211;1999 trends of temperature and circulation in the stratosphere are about 20&#8211;25% the magnitude of those of the ozone depletion era, and are broadly consistent with expectations based on modeled depletion-era trends and variability of both ozone and reactive chlorine, thereby indicating the emergence of healing of dynamical impacts of the Antarctic ozone hole. </p>
PERUBAHAN JARINGAN DAN EKSPRESI HORMON STEROID OVARI LOBSTER PASIR (Panulirus homarus) YANG DIPELIHARA DENGAN MANIPULASI PAKAN DAN LINGKUNGAN

Lobster merupakan salah satu komoditas perikanan yang potensial. Setiap tahunnya permintaan akan lobster terus meningkat yang mengakibatkan terjadinya penangkapan berlebih yang dapat menurunkan populasi di alam. Untuk menjamin ketersediaan lobster untuk dikonsumsi dan penebaran kembali kealam dapat dilakukan dengan budidaya. Kurangnya informasi dalam pematangan gonad induk lobster menjadikan proses pemijahan belum dapat dilakukan dengan baik. Penelitian ini bertujuan untuk mempelajari perubahan jaringan dan ekspresi hormon steroid pada ovari lobster pasir (Panulirus homarus) dengan manipulasi pakan dan lingkungan. Perubahan tingkat kematangan gonad (TKG) dapat diketahui dengan perubahan warna pada ovari mulai dari ovari yang berwarna putih (TKG I), kekuningan (TKG II) dan mendekati oranye (TKG III). Perubahan ini semakin jelas dengan analisa histologi ditandai munculnya sel-sel folikel primer pada TKG I, munculnya jaringan penghubung fibrous pada TKG II dan munculnya oosit previtelogenik dan globular lipida pada TKG III. Tingkat konsentrasi hormonal yang berperan dalam pematangan ovari yaitu sitokin, progesteron dan estradiol menunjukkan perubahan konsentrasi mengikuti perubahan TKG (p<0,05). Hormon sitokin pada TKG I paling tinggi 24, 2 pg/mL dan berturut-turut turun TKG II 14,71 pg/mL dan TKG III 10 pg/mL. Perubahan ekspresi hormon progesteron juga mengalami penurunan mengikuti naiknya TKG dan penurunan tersebut signifikan menurut perubahan TKG (p<0,05). Pada TKG I tertinggi yaitu 74,92 pg/mL, diikuti menurunnya ekspresi pada TKG II sebesar 55,5 pg/mL dan TKG III sebesar 25,25 pg/mL. Perubahan ekspresi hormon estradiol menunjukkan fluktuasi naik dan turun, tidak seperti hormon sitokin dan progesteron yang konsisten turun. Konsentrasi hormon estradiol tertinggi terjadi pada TKG II 44 pg/mL diikuti oleh TKG I 35,14 pg/mL dan TKG III 29,73 pg/mL. Perubahan ekspresi pada hormon estradiol signifikan menurut perubahan TKG (p<0,05). Hasil di atas menunjukan ekspresi hormon steroid mengikuti tingkat kematangan gonad. Hal tersebut menyatakan bahwa manipulasi pakan dan lingkungan dapat mendukung perubahan tingat kematangan ovari lobster pasir. Kata kunci : histologi, hormon steroid, kematangan gonad, lobster pasir, manipulasi pakan.
Recent developments in muscle synergy analysis in young people with neurodevelopmental diseases: A Systematic Review

The central nervous system simplifies motor control by sending motor commands activating groups of muscles, known as synergies. Physiological locomotion can be described as a coordinated recruitment of four to five muscle synergies. The first studies on muscle synergies in patients affected by neurological diseases were on stroke survivors. They showed that synergies can be used as biomarkers for motor impairment as they vary in patients with respect to healthy people. Likewise, muscle synergy analysis has been applied to developmental diseases (DD). The need for a comprehensive view of the present findings is crucial for comparing results achieved so far and promote future directions in the field. In the present review, we screened three scientific databases and selected thirty-six papers investigating muscle synergies extracted from locomotion in children affected by DD. Thirty-one articles investigate how cerebral palsy (CP) influences motor control, the currently exploited method in studying motor control in CP and finally the effects of treatments in these patients in terms of synergies and biomechanics; two articles investigate how muscle synergies vary in Duchenne muscular dystrophy (DMD), and three other articles assess other developmental pathologies, such as chronic and acute neuropathic pain. For CP, most of the studies demonstrate that the number of synergies is lower and that the synergy composition varies in the affected children with respect to normal controls. Still, the predictability of treatment’s effects and the etiology of muscle synergy variation are open questions, as it has been reported that treatments minimally modify synergies, even if they improve biomechanics. The application of different algorithms in extracting synergies might bring about more subtle differences. Considering DMD, no correlation was found between non-neural muscle weakness and muscle modules’ variation, while in chronic pain a decreased number of synergies was observed as a possible consequence of plastic adaptations. Even if the potential of the synergistic approach for clinical and rehabilitation practices is recognized, there is not full consensus on protocols nor widely accepted guidelines for the systematic clinical adoption of the method in DD. We critically commented on the current findings, on the methodological issues and the relative open points, and on the clinical impact of muscle synergies in neurodevelopmental diseases to fill the gap for applying the method in clinical practice.
The effect of adding turmeric and artemisia herba powder to ration on productive performance of white laying hens

The study was aimed to improve the productive performance of white laying hens, using two types of medicinal herbs, including turmeric and Artemisia Herba. In the experiment 63 laying hens (white shevar) were used at an age of 24 weeks, hens were divided randomly in to three treatment 21 hens pre treatment with 3 replicate of 7 hens per replicate. A standard ration was used without any addition, which was considered as the control treatment (T1), the basic ration, plus turmeric powder (0.5%) (T2), while the treatment (T3) represented the basic ration plus Artemisia Herba powder by 0.5%. The study included the measurements of egg production, egg weight, feed consumption, feed conversion ratio and egg mass. The results showed a significant improvement (P<0.05) in the characteristics of egg production ratio, feed conversion ratio and egg mass for the treatment with the addition of Artemisia Herba flower (T3) compared with other treatments, and significant decrease (P<0.05) in the amount of feed consumed (T2, T3) as compared with the control treatment (T1), while the results did not show any significant differences to addition of turmeric to the ration (T2) in the productive performance as compared to the control treatment. It was concluded from that the addition of Artemisia Herba to the ration resulted in a significant improvement in most of the productive performance of laying hens as compared to other treatments.
ULTRASOUND USE FOR LISTERIA MONOCYTOGENES ATTACHED CELLS REMOVAL FROM INDUSTRIAL BRINE INJECTION NEEDLES

This work aimed at studying methods for Listeria monocytogenes attached cells removal from food industry equipment. In order to verify possible contamination points, a tracking was carried out in food products and equipment surfaces (brine injection needles) by swab. Brine injection needles were defined as a study due to their higher contamination potential. L. monocytogenes adhesion after 6 h contact with needles was observed. Minimum bactericidal concentration (MBC) of peracetic acid on L. monocytogenes attached cells was 0.06 and 0.24% with 6 and 24 h contact with bacteria, respectively. 75% power (700 W) and 14 min exposure ultrasound treatment showed a 3.25 Log CFU microbial load reduction in injection needles. The combination of ultrasound and peracetic acid showed an MBC reduction from 0.24 to 0.03%, hence, it may be recommended for meat industry application.
The clinically important anaerobic, human pathogenic Bacteroides species and their antibiotic resistance levels in Central and Southeast Europe

Abstract The Bacteroides and Parabacteroides species are important obligate anaerobic bacteria that are significant constituents of normal flora (microbiota), and opportunistic pathogens with special biological background. They are highly resistant to antibiotics and monitoring their resistance levels is important for their empiric therapy. Several antibiotic resistance studies were conducted in the USA and Europe and we have data for the region involved in this study showing comparable trends. Multidrug-resistant strains are emerging among Bacteroides too, where the proper antibiotic tests and treatments may be life-saving.
T-cell activation is modulated by the 3D mechanical microenvironment

T cells recognize mechanical forces through a variety of cellular pathways, including mechanical triggering of the T-cell receptor (TCR) and mechanical triggering of the integrin LFA-1. We show here that T cells can recognize forces arising from the rigidity of the microenvironment. We fabricated 3D hydrogels with mechanical stiffness tuned to 4 kPa and 40 kPa and specially engineered be microporous independent of stiffness. We cultured T cells and antigen presenting cells within the matrices and studied activation by flow cytometry and live imaging. We found there was an augmentation of T-cell activation in the context of mechanically stiffer 3D material as compared to the softer material. In contrast, proliferation, activation markers, and migration were all diminished in T cells cultured in the softer material. These results show that T cells can sense their mechanical environment and amplify responses in the context of mechanical stiffness.
Taxonomic reassessment of Ulva prolifera (Ulvophyceae, Chlorophyta) based on specimens from the type locality and Yellow Sea green tides

Abstract: Since 2008, the green seaweed Ulva prolifera has caused the world's largest green tide in the Yellow Sea, China. It has subsequently attracted considerable research interest. However, species identification is an essential step for advancing this research. Based on phylogenetic analyses using molecular sequences such as internal transcribed spacer (ITS) or ribulose bisphosphate carboxylase large chain (rbcL), specimens of U. prolifera collected worldwide were separated into a European clade and the Ulva linza–procera–prolifera (LPP) complex clade that included the Chinese bloom-forming strains and Japanese brackish strains. This has resulted in considerable controversy as to the identity of U. prolifera and the bloom-forming species in the Yellow Sea. To resolve this issue, we examined populations of U. prolifera from the type locality at Lolland Island, Denmark, and globally significant sites including sites from Japan and China using morphological, developmental, molecular and crossing studies. We found that almost all the Danish strains agree with the description of the type specimen and were included in the LPP clade. They had a branched morphology in culture and an obligate asexual life history with quadriflagellate zoosporoids. We conclude that this taxon in the LPP clade is true U. prolifera. Based on culture morphology, mating compatibility and the 5S rDNA spacer sequences, the Chinese bloom-forming strains were distinct, and the new subspecies U. prolifera subsp. qingdaoensis subsp. nov. is described. Strains of the European clade showing gamete incompatibility with the sexual members of the LPP clade were assigned to the species Ulva splitiana.
Unveiling the transcriptome complexity of the High- and Low-Zinc & Iron accumulating Indian wheat (Triticum aestivum L.) cultivars

Development of Zinc (Zn), Iron (Fe) and other minerals rich grains along with various stress tolerance and susceptible (STR) wheat genotype, will help to reduce globally spread malnutrition problem. Current study deals with transcriptome profiling of 4 high- and 3 low- Zn & Fe accumulating wheat genotypes (HZFWGs) and (LZFWGs). Functional characterization of expressed and high and low specific genes, accompanied by metabolic pathways analysis reveals, phenylpropanoid biosynthesis, and other associated pathways are mainly participating in plant stress defense mechanism in both genotypes. Chlorophyll synthesis, Zn & Fe binding, metal ion transport, and ATP-Synthase coupled transport mechanism are highly active in HZFWGs while in LZFWGs ribosomal formation, biomolecules binding activities and secondary metabolite biosynthesis. Transcripts accountable for minerals uptake and purine metabolism in HZFWGs are highly enriched. Identified transcripts may be used for marker-assisted selection and breeding to develop minerals rich crops.
SIMNETS: a computationally efficient and scalable framework for identifying networks of functionally similar neurons

We present the Similarity Networks (SIMNETS) algorithm, a computationally efficient and scalable method for identifying groups of functionally related neurons within larger, simultaneously recorded ensembles. Our approach begins by independently measuring the intrinsic relationship between the activity patterns of each neuron across experimental conditions before making comparisons across neurons (instead of directly comparing firing patterns using measures such as correlations in firing rate or synchrony). This strategy estimates the intrinsic geometry of each neuron’s output space and allows us to capture the information processing properties of each neuron in a format that is easily compared between neurons. Dimensionality reduction tools are then used to map the pairwise neuron comparisons into a low-dimensional space where groupings of functionally related neurons are identified using clustering techniques. The algorithm’s computational complexity scales almost linearly with the number of neurons analyzed and makes minimal assumptions about single-unit encoding properties, making SIMNETS especially well-suited for examining large networks of neurons engaged in complex behaviors. We validate the ability of our approach to detect functional groupings using simulated data with known ground-truth as well as three datasets including ensemble activity from primate primary visual and motor cortex as well as rat hippocampal CA1 region.