Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Mutation in HOXB1 Gene and Acute Myeloid Leukemia

Background: HOX genes are an exceedingly preserved family of homeodomain-involving transcription factors. They are related to a number of malignancies, comprising acute myeloid leukemia (AML). This study aimed to evaluate the effect of HOXB1 7bp deletion mutation on HOXB1gene expression in 36 individuals. Materials and Methods: The present cross-sectional study was done on a large Iranian family. In this experimental study, 5 homozygous 7bp deletion individuals along with their unaffected siblings and their parents were investigated. The candidate gene, HOXB1 was screened and analyzed in blood samples of these participants. After RNA extraction, cDNA was synthesized according to manufacturer’s protocol. HOXB1 expression level was analyzed by 2ΔΔCT method. All laboratory procedures used in this experimental study were carried out in genetic laboratory of Shahid Sadoughi University of Medical Sciences. Results: Sequence analysis of HOXB1 gene by ABI Prism 3130 Genetic Analyzer (Applied Biosystems, Foster City, CA, USA) revealed a family with 5 homozygous (22±17 years) and 22 healthy heterozygous carriers (42±19 years) for 7bp deletion in HOXB1 gene along with 9 healthy wild type (55±41 years). Gene expression analysis by RT-qPCR demonstrated that expression level of HOXB1 gene in wild type and heterozygous carriers specimens had similar levels (p=0.05). Conclusion: Although HOXB1 mutations has been reported in AML, but association between HOXB1 mutation and AML was not found in our study. Additionally, HOXB1 expression levels showed no significant difference between wild type and heterozygous carriers. So, HOXB1 gene expression cannot provide a powerful tool to differentiate wild type from heterozygous carries.
Coupling between magnetic ordering and structural instabilities in perovskite biferroics: a first-principles study

We use first-principles density-functional-theory-based calculations to investigate structural instabilities in the high symmetry cubic perovskite structure of rare-earth ($R=\text{La}$, Y, Lu) and Bi-based biferroic chromites, focusing on $\ensuremath{\Gamma}$ and $R$ point phonons of nonmagnetic, ferromagnetic, and antiferromagnetic states. We find that (a) the structure with $G$-type antiferromagnetic ordering is most stable, (b) the most dominant structural instabilities in these oxides are the ones associated with rotations of oxygen octahedra, and (c) structural instabilities involving changes in Cr-O-Cr bond angle sensitively depend on the changes in magnetic ordering. The dependence of structural instabilities on magnetic ordering can be understood in terms of how superexchange interactions depend on the Cr-O-Cr bond angles and Cr-O bond lengths. We demonstrate how adequate buckling of Cr-O-Cr chains can favor ferromagnetism. Born effective charges calculated by using the Berry phase expression are found to be anomalously large for the $A$ cations, indicating their chemical relevance to ferroelectric distortions.
Coordination strategy of financial services and operations management in supply chain of capital-constrained retailer

Based on the assumption of a capital-constrained retailer who may face bankruptcy costs because of financing, the coordination decision on financial services and operational management in two-level supply chain composed of a retailer and a supplier is studied. The results show that the retailer has a limited financing capacity and a limited order levels under uncertain demand distribution. A capital-constrained retailer may achieve the optimal order and create value for the supply chain through external financial services. In addition, the results also show that risk-free rate,the retailer’s amount of initial capital and rate of bankruptcy costs can impact on retailer’s ordering strategy, supplier’s wholesale strategy and supply chain performance.
Answering Label-Constraint Reachability in Large Graphs

In this paper, we study a variant of reachability queries, called label-constraint reachability (LCR) queries, specifically, given a label set S and two vertices u1 and u2 in a large directed graph G, we verify whether there exists a path from u1 to u2 under label constraint S. Like traditional reachability queries, LCR queries are very useful, such as pathway finding in biological networks, inferring over RDF (resource description f ramework) graphs, relationship finding in social networks. However, LCR queries are much more complicated than their traditional counterpart. First, in order to minimize the search space in computing path-label transitive closure, we develop two techniques: 1) we transform an edge-labeled directed graph into an augmented DAG by representing the maximal strongly connected components as bipartite graphs; 2) we redefine path “distance” and propose a Dijkstra-like algorithm to compute path-label transitive closure. Compared with the existing solution, we prove that our method is optimal in terms of search space; Second, in order to address the scalability, we propose a simple yet effective partition-based framework (local path-label transitive closure + online traversal) to answer LCR queries in large graphs. We prove that finding the optimal graph partition to speed up query processing is NP-hard by reducing the classical min-cut graph partition problem. Thus, we propose a sampling-based solution to find the sub-optimal partition. Finally, we demonstrate the superiority of our method by extensive experiments.
ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid malignancies with very few therapeutic options to treat advanced or metastatic disease. The utilization of genomic sequencing has identified therapeutically relevant alterations in approximately 25% of PDAC patients, most notably in the DNA damage response and repair (DDR) genes, rendering cancer cells more sensitive to DNA-damaging agents and to DNA damage response inhibitors, such as PARP inhibitors. ATM is one of the most commonly mutated DDR genes, with somatic mutations identified in 2% to 18% of PDACs and germline mutations identified in 1% to 34% of PDACs. ATM plays a complex role as a cell-cycle checkpoint kinase, regulator of a wide array of downstream proteins, and responder to DNA damage for genome stability. The disruption of ATM signaling leads to downstream reliance on ATR and CHK1, among other DNA-repair mechanisms, which may enable exploiting the inhibition of downstream proteins as therapeutic targets in ATM-mutated PDACs. In this review, we detail the function of ATM, review the current data on ATM deficiency in PDAC, examine the therapeutic implications of ATM alterations, and explore the current clinical trials surrounding the ATM pathway.
Biodegradation Of Polyhydroxyalkanoates

The biodegradation of Polyhydroxybutyrate (PHB) and its copolymer Polyhydroxybutyrate-co-hydroxyvalerate (PHB-co-HV) was studied. Bacterial as well as fungal isolates were isolated from 9 different ecosystems. All these isolates were tested for the degradation of the above polymers in assay agar medium as well as in liquid cultures. The culture biomass and the clear zone around the colonies were measured to evaluate the activity of these isolates. In all, the fungal isolates were found to degrade these polymers more rapidly when compared to bacteria, due to their versatile depolymerase activities.
Title Geometrical shaping of InGaN light-emitting diodes by lasermicromachining

Geometrical shaping of InGaN light-emitting diodes (LEDs) by laser micromachining is introduced. The sapphire substrate is shaped with inclined sidewalls at 50 , serving as a prism favoring light redirection for out-coupling from the top window. Compared to conventional cuboid LEDs with a calculated light extraction efficiency of 18.3%, these shaped LEDs offers a pronounced increase in of up to 85.2%, verified by experimental results.
Kalium und Magnesium in der Pulmologie C .

P . b . b . G Z 0 2 Z 0 3 1 1 0 8 M , V e r l a g s p o s t a m t : 3 0 0 2 P u r k e r s d o r f , E r s c h e i n u n g s o r t : 3 0 0 3 G a b l i t z Indexed in SCOPUS/EMBASE/Excerpta Medica www.kup. at/mineralstoffwechsel Österreichische Gesellschaft für Orthopädie und Orthopädische Chirurgie Österreichische Gesellschaft für Rheumatologie Offizielles Organ der Österreichischen Gesellschaft zur Erforschung des Knochens und Mineralstoffwechsels Member of the Kalium und Magnesium in der
Measuring Of Real-Time Traffic Flow Using Video From Multiple IP-Based Cameras

Developing an intelligent transportation system that contains the basic information of the real-time traffic flow helps Lembaga Lebuhraya Malaysia to monitor and manage the traffic flow of our country. The main purpose of this paper is to detect and count vehicles along with its direction either towards North or South in real-time traffic flow by using multiple IP-based cameras. Open Source Computer Vision Library (OpenCV) and Python Programming language is used to implement the method developed. The project also provides an improvement by developing the system to be implemented in multiple cameras for real-time traffic measurement. The number of vehicles and their directions which are the output of the developed system is stored in json file to keep track of the data as well as the name of cameras with the time it is processed. The system developed is hoped to be a starting point in developing a more complex system.
MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection

Coxsackievirus B (CVB) is the major cause of human myocarditis and dilated cardiomyopathy. Toll-like receptor 3 (TLR3) is an intracellular sensor to detect pathogen's dsRNA. TLR3, along with TRAF6, triggers an inflammatory response through NF-κB signaling pathway. In the cells infected with CVB type 3 (CVB3), the abundance of miR-146a was significantly increased. The role of miR-146a in CVB infection is unclear. In this study, TLR3 and TRAF6 were identified as the targets of miR-146a. The elevated miR-146a inhibited NF-κB translocation and subsequently down-regulated proinflammatory cytokine expression in the CVB3-infected cells. Therefore, the NF-κB pathway can be doubly blocked by miR-146a through targeting of TLR3 and TRAF6. MiR-146a may be a negative regulator on inflammatory response and an intrinsic protective factor in CVB infection.
Teaching Effectiveness, Course Evaluation, and Academic Performance: The Role of Academic Delay of Gratification

Academic delay of gratification is a significant and positive predictor of students’ final course grades, even after controlling for the effect of their rating of the course, expected grade, and degree of interest, importance, and utility of the academic task. Students’ expected course grades are by far the strongest predictor of their final course grades. This suggests a student's expected grade in a course is associated with academic achievement in that course. Because expectation of grades alone should not be the focus of students’ motivation, students need to learn how to use other factors to motivate themselves and to develop learning strategies that support mastery and a mastery orientation. Students’ ratings of a course are not a significant predictor of their final course grades, which suggests that students’ perception of the course are not directly associated with the grades they obtained in the course. This suggests that academic delay of gratification helps students to orchestrate their academic progress, enactment of goals, task completion, and eventual academic achievement. Judging by its role in predicting students’ final course grades, academic delay of gratification explains a statistically significant amount of variance in students’ academic achievement.
H E ] 4 M ar 2 01 4 Optical / infrared observations unveiling the formation , nature and evolution of High-Mass X-ray Binaries ✩

In this review I first describe the nature of the three kinds of High-Mass X-ray Binaries (HMXBs), accreting through: i. Be circumstellar disc, ii. supergiant stellar wind, and iii. Roche lobe filling supergiants. I then report on the discovery of two new populations of HMXBs hosting supergiant stars, recently revealed by a wealth of new observations, coming from the high energy side (INTEGRAL, Swift, XMM, Chandra satellites), and complemented by multi-wavelength optical/infrared observations (mainly ESO facilities). The first population is constituted of obscured supergiant HMXBs, the second one of supergiant fast X-ray transients (SFXTs), exhibiting short and intense X-ray flares. I finally discuss the formation and evolution of HMXBs, constrain the accretion models (e.g. clumpy winds, transitory accretion disc, magnetocentrifugal barrier), show evidences suggesting the existence of an evolutionary link, include comparisons with population synthesis models, and finally First, I would like to thank the organizers of the COSPAR event dedicated on SFXTs, Lara Sidoli and Vito Sguera. Then, I am grateful to the two anonymous referees who gave me useful comments and helped me to improve this review. Finally, I am lifelong indebted to my close collaborators on the study of INTEGRAL sources: A. Coleiro, P.A. Curran, Q.Z. Liu, I. Negueruela, L. Pellizza, F. Rahoui, J. Rodriguez, M. Servillat, J.A. Tomsick, J.Z. Yan, and particularly J.A. Zurita Heras for many fruitful discussions, and the realisation of Figures 1, 3 and 4. This work was supported by the Centre National d’Etudes Spatiales (CNES), based on observations obtained with MINE – the Multi-wavelength INTEGRAL NEtwork –. ∗Corresponding author Email address: chaty@cea.fr (Sylvain Chaty) Preprint submitted to Advances in Space Research March 5, 2014 build a consistent scenario explaining the various characteristics of these extreme celestial sources. Because they are the likely progenitors of Luminous Blue Variables (LBVs), and also of neutron star/black hole binary mergers, related to short/hard gamma-ray bursts, the knowledge of the nature, formation and evolution of these HMXB populations is of prime importance.
Optimized Design of Low Voltage High Current Ferrite Planar Inductor for 10 MHz On-chip Power Module

In this paper, design parameters of high Q (> 50), high current inductor for on-chip power module were optimized by 4 Xs 3 Ys DOE (Design of Experiment). Coil spacing, coil thickness, ferrite thickness, and permeability were assigned to Xs, and inductance (L) and Q factor at 10 MHz, and resonance frequency ( fr) were determined Ys. Effects of each X on the Ys were demonstrated and explained using known inductor theory. Multiple response optimizations were accomplished by three derived regression equations on the Ys. As a result, L of 125 nH, Q factor of 197.5, and fr of 316.3 MHz were obtained with coil space of 127 μm, Cu thickness of 67.8 μm, ferrite thickness of 130.3 μm, and permeability 156.5. Loss tan δ = 0 was assumed for the estimation. Accordingly, Q factor of about 60 is expected at tan δ = 0.02.
Evaluating extended-release calcifediol as a treatment option for chronic kidney disease-mineral and bone disorder (CKD-MBD)

ABSTRACT Introduction: Extended-release calcifediol (ERC) is an orally administered prohormone of active vitamin D (1,25-dihydroxyvitamin D [1,25D]) designed to safely and sufficiently increase serum total 25-hydroxyvitamin D (25D) to reduce elevated parathyroid hormone (PTH) in patients with non-dialysis-chronic kidney disease (ND-CKD). ERC is currently approved in the United States and Canada. Areas covered: Herein, key clinical data relating to the pharmacokinetics, pharmacodynamics, efficacy and safety of ERC are reviewed. Expert opinion: Currently available treatment options for secondary hyperparathyroidism (SHPT) in ND-CKD have limitations: the effectiveness of nutritional vitamin D supplements for reduction of PTH levels is unproven and active (1α-hydroxylated) vitamin D analogues elevate serum calcium, which increases the risk of hypercalcemia and vascular calcification. Clinical studies show that ERC is an effective, well tolerated treatment for SHPT in ND-CKD. ERC gradually raises serum 25D levels, resulting in physiologically regulated increases in serum 1,25D and sustained reductions in PTH, while avoiding clinically meaningful increases in serum phosphorus, calcium and fibroblast growth factor 23. ERC offers a new, effective and well tolerated treatment option for the early management of SHPT in patients with ND-CKD.
The dark matter is mostly an axion BEC

Axions differ from ordinary cold dark matter, such as WIMPs or sterile neutrinos, because they form a Bose-Einstein condensate (BEC). As a result, axions accreting onto a galactic halo fall in with net overall rotation. In contrast, ordinary CDM accretes onto galactic halos with an irrotational velocity field. The inner caustics are different in the two cases. It is shown that if the dark matter is axions, the phase space structure of the halos of isolated disk galaxies, such as the Milky Way, is precisely that of the caustic ring model for which observational support exists. The other dark matter candidates predict a far more chaotic phase space structure for galactic halos.
Growth, longevity and age at maturity in the European whip snakes, Hierophis viridiflavus and H. carbonarius

Age and size at maturity are major life history traits, because they influence lifetime fecundity. They represent the outcome from complex interactions among environmental pressures (abiotic and biotic) and individual characteristics. They are also difficult to measure in natural populations and thus they are rarely appraised, especially in reptiles due to the elusive nature of juveniles. Using skeletochronology to circumvent these difficulties, this study aims to compare age structures, longevity, age-size relationships, growth curves, age and size at maturation and potential reproductive lifespan in three populations of the European whip snake (two Hierophis viridiflavus , one H. carbonarius ). We measured the body size and counted the skeletal growth marks on 132 specimens, accidentally killed or from museum collections (72 from NW France [Chize]; 28 from Tuscan Archipelago [Montecristo], Italy; 32 from S Italy [Calimera]). General patterns of age at maturity and longevity were consistent with previous studies based on recapture investigations. Strong differences among populations suggest local adaptation to contrasted environmental conditions. These results suggest that skeletochronology is a useful technique that can be applied opportunistically in snakes (e.g. using road-kills) in order to collect otherwise unavailable data that are essential to address fundamental questions regarding longevity, life-history traits and to perform population viability analyses.
DA DOENÇA PERIODONTAL CRÔNICA : revisão de literatura

A terapia fotodinâmica é uma nova alternativa terapêutica não invasiva com maior especificidade de sítios e patógenos, essa técnica combina a energia do laser com um fotossensibilizador para produzir moléculas de oxigênio singleto (estado excitado) e radicais livres para destruir os periodonto patógenos sem produzir danos aos tecidos hospedeiros adjacentes. Esta pesquisa foi um estudo bibliográfico, no qual foram selecionados 25 ensaios clínicos controlados randomizados, no período de 2010 a 2017 para serem analisadas e atender o objetivo de avaliar o desempenho da Terapia fotodinâmica como alternativa de tratamento da doença periodontal crônica. Os parâmetros avaliados foram: índice de placa, índice de sangramento, profundidade de sondagem, nível de inserção clinico. Os estudos sugerem que a Terapia Fotodinâmica oferece vantagens na modulação de citocinas. É um tratamento indolor, que apresenta resultados positivos em curto prazo. A desvantagem da terapia fotodinâmica é o custo elevado e o efeito prolongado, que ainda é desconhecido e necessita de mais estudos. É um recurso adicional a ser utilizada no tratamento da periodontite crônica junto com a terapia periodontal básica convencional. Porém necessita de estudos a longo prazo para comprovar sua eficácia.
The H3 histone chaperone NASP escorts CenH3 in Arabidopsis

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/tpj.14518 This article is protected by copyright. All rights reserved. DR INNA LERMONTOVA (Orcid ID : 0000-0003-3386-2590) Article type : Original Article
Towards a DNA taxonomy of Caribbean demosponges : a gene tree reconstructed from partial mitochondrial CO 1 gene sequences supports previous rDNA phylogenies and provides a new perspective on the systematics of Demospongiae

We present the most comprehensive cytochrome oxidase subunit 1 gene tree published to date for demosponges based on new sequences. The CO1 barcoding fragment is sequenced for 65 species from the Caribbean Sea, and its gene tree reconstructed. Although its deeper nodes are not particularly well-supported, the gene tree provides a variety of information for new phylogenetic patterns, as well as support for previously published 28S rDNA gene trees. In our analysis Halichondriidae cluster with Suberitidae, supporting previous 28S rDNA data. Chelae-bearing Poecilosclerida are monophyletic but most taxa lacking chelae in this dataset cluster more distantly. Haplosclerida are not resolved monophyletically under this fragment. While some species exhibit distinct barcodes, some genera contain species that share CO1 haplotypes.
Untargeted characterisation of dissolved organic matter contributions to rivers from anthropogenic point sources using direct‐infusion and high‐performance liquid chromatography/Orbitrap mass spectrometry

Rationale Anthropogenic organic inputs to freshwaters can exert detrimental effects on aquatic ecosystems, raising growing concern for both environmental conservation and water security. Current regulation by the EU water framework directive (European Union, 2000/60/EC) relates to organic pollution by monitoring selected micropollutants; however, aquatic ecosystem responses require a comprehensive understanding of dissolved organic matter (DOM) composition. The introduction of high‐resolution mass spectrometry (HRMS) is set to greatly increase our understanding of the composition of DOM of both natural and anthropogenic origin derived from diffuse and point sources. Methods DOM was extracted from riverine and treated sewage effluent using solid‐phase extraction (SPE) and analysed using dissolved organic carbon analysis, direct‐infusion high‐resolution mass spectrometry (DI‐HRMS) and high‐performance liquid chromatography (HPLC)/HRMS. The data obtained were analysed using univariate and multivariate statistics to demonstrate differences in background DOM, anthropogenic inputs and in‐river mixing. Compound identifications were achieved based on MS2 spectra searched against on‐line databases. Results DI‐HRMS spectra showed the highly complex nature of all DOM SPE extracts. Classification and visualisation of extracts containing many thousands of individual compounds were achieved using principal component analysis (PCA) and hierarchical cluster analysis. Kruskal‐Wallis analyses highlighted significant discriminating ions originating from the sewage treatment works for more in‐depth investigation by HPLC/HRMS. The generation of MS2 spectra in HPLC/HRMS provided the basis for identification of anthropogenic compounds including; pharmaceuticals, illicit drugs, metabolites and oligomers, although many thousands of compounds remain unidentified. Conclusions This new approach enables comprehensive analysis of DOM in extracts without any preconceived ideas of the compounds which may be present. This approach has the potential to be used as a high throughput, qualitative, screening method to determine if the composition of point sources differs from that of the receiving water bodies, providing a new approach to the identification of hitherto unrecognised organic contribution to water bodies.