Miracle-dz/UniFAR-FTUs huggingface dataset:
Research methods for animal studies of the anxiolytic drugs

One out of thirteen people are suffering from Anxiety disorders. So many drugs are available in market. But none of the drug is said to be safe. This lack of safety gives scope of future trials of newer anxiolytic drugs. This review focuses on the various Research Methods for studying the anxiolytic effect of drugs. The various methods are divided into two parts Conditioned responses and Unconditioned responses. Under Conditioned responses, various methods areGeller–Seifter conflict (GS), Vogel conflict, Fourplate test (FPT), Conditioned emotional response (CER), Conditioned taste aversion (CTA), Fearpotentiated startle, Defensive burying, Active/passive avoidance. Under Unconditioned responses, various methods are Elevated plus maze (zero/T maze), Light/dark exploration (L/D), Social interaction, Open field, Ultrasonic vocalization (pain or separation), Fear/anxiety-defence test batteries, Staircase test, Holeboard and Predator.
Ecological design based on bio-models in sustainable development

The article considers the possibilities of a new environmental approach to design. Nature presents us with such opportunities. Evolution has led to an environmentally friendly solution to the interaction of the body and its environment. Currently, architects and engineers are trying to solve the processes of environmental design approaches. It is enough to see these solutions in the bio model, to determine the laws of existence for applying its qualities in the shaping of the designed architectural object in the environment. The application of the mechanisms of functioning of the bio model will be distinguished by the originality of engineering work and aesthetic diversity. The formation of the concept allows simulating the architectural and environmental space for a specific environment. The uniqueness of the natural environment component explains the typical design decisions for specific environmental conditions. Bio models of the Astrakhan region considered to identify environmental design methodology. An analysis of the methods for adapting bio models to the landscape and climatic conditions of the considered area and their growth is necessary for the application of these methods in architectural shaping and engineering and technical support of the designed facility for specific conditions of the city of Astrakhan. Thus, the similarity of the strategy of natural components considered by steppe, floodplain, and marine plants lays the potential for creating a model in the sustainable urban development of spaces with ecological and favorable living conditions for humans and nature.
Effects of DRP-1 Inhibitors in Healthy and Diseased Myocardium

Coronary heart disease (CHD) continues to be one of the foremost contributors to morbidity and mortality in developed countries. Leading risk factors that include elevated blood pressure, hypercholesterolaemia, tobacco use, sedentary lifestyles and excess caloric consumption significantly contribute to these alarmingly high mortality rates and prompt the search for targeted interventions that are clinically effective. Myocardial ischaemia, occurring in ischaemic heart disease (IHD) or during cardiac surgery, reduces coronary blood flow to the metabolically active myocardium – the former primarily due to progression of coronary vascular atherosclerosis and associated thromboembolism, the latter due to the need to arrest perfusion of myocardial tissue in different surgical scenarios (e.g. cardiac transplant, by-pass surgery, valve surgery). Insufficient blood flow to the myocardium reduces oxygen and metabolic substrate delivery, and removal of waste products. Since the myocardium is highly oxidative, periods of ischaemia are detrimental, with brief episodes causing cardiac dysfunction and more prolonged insult leading to cell death. Reduced oxygen delivery and subsequent reoxygenation can profoundly impact mitochondrial function, the energy producing ‘powerhouses’ of the cell. Emerging research has confirmed that mitochondria are a network of dynamic organelles undergoing cycles of fragmentation (fission) and elongation (fusion), a quality control process thought to maintain a healthy population of mitochondria matched to prevailing metabolic conditions. Mitochondrially targeted interventions have thus emerged as an exciting therapeutic option across organ systems and diseases, including in the heart and IHD. However, the heart is somewhat unique in its mitochondrial phenotype, with evidence the healthy heart possesses a fragmented mitochondrial population that generates the highest densities and respiratory capacity in mammalian cells. Moreover, these mitochondria do not appear to undergo active cycles of fission/fusion. Thus, the utility of therapy targeting fission/fusion in the heart is unclear.
Should the cardiac rhythm be monitored following administration of zoledronic acid in elderly osteoporotic women

1Department of Physical Medicine and Rehabilitation, Medical Faculty of Namık Kemal University, Tekirdağ, Turkey 2Clinical Pharmacologist, Pharmacist, Department of Pharmacovigilance, Materiovigilance, and Raitonal Use of Drugs, State Hospital, Ministry of Health, Republic of Turkey, Tekirdağ, Turkey 3Department of Cardiology, Medical Faculty of Namık Kemal University, Tekirdağ, Turkey 4Department of Public Health, Medical Faculty of Namık Kemal University, Tekirdağ, Turkey 5Department of Obstetrics and Gynecology, Medical Faculty of Namık Kemal University, Tekirdağ, Turkey
Mouse Control Using Head Movement

This system can be adapted accurately for detecting facial features. It is a free line up that allows you to control the pointer of the mouse on a processor with the help of head movements. The movements of head are liberated clicking with the help of mouse pointer abide over a spot on the screen. This is application which is helpful for the people who are disabled. The foremost spectators for this program are people who do not have committed control of a hand but who can only move their head. Citizens with, Spinal Cerebral Palsy, ALS (Amyotrophic lateral sclerosis), Muscular Atrophy, Traumatic Brain Injury, Multiple Sclerosis, various neurological disorders use this program and its predecessor to run all types of processor software.
Relatively semi-conservative replication and a folded slippage model for simple sequence repeats

Simple sequence repeats (SSRs) are found ubiquitously in almost all genome, and their formation mechanism is ambiguous yet. Here, the SSRs were analyzed in 55 randomly selected segments of genomes from a fairly wide range of species, with introducing more open standard for extensively mining repeats. A high percentage of repeats were discovered in these segments, which is inconsistent with the current theory suggested that repeats tend to disappear over long-term evolution. Therefore, a mechanism is most probably responsible for continually producing repeats during replication to balance continuous repeat disappearance, which may makes the replicating process relatively semi-conservative. To improve the current straight-line slippage model, we proposed a folded slippage model involving the geometric space of nucleotides and hydrogen bond stability to explain the high-percent SSR occurrence, which can describe SSR expansion and contraction more reasonably. And analysis of external forces in the folding template strands suggested that the microsatellites tend to expand than contract. Our research may provide implements for contributions of microsatellites to genome evolution and complement semi-conservative replication.
Maternal Near Miss and Still birth in developing countries: A Systematic Review with Meta-Analysis

Background: Maternal near miss during pregnancy and delivery are known to increase the odds of still birth. Although the available few studies suggested the association between maternal near miss and still birth, pooled effect of individual studies is not yet known for developing countries. Hence the aim of the Meta-analysis was to quantify the association between maternal near miss and still birth from studies conducted in developing countries. Method: Electronic data bases like MEDLINE and Embase were used to search for relevant articles. Observational studies which were published in English language, irrespective of publication status were considered. The methodological quality of the studies included in the current review was done using the Newcastle Ottawa assessment scale and British Sociological Association Medical Sociology Group quality indicators. Pooled estimate along with 95% CI were calculated using random effect model. I2 statistics were used to test for heterogeneity. Forest plot were used to present findings. Egger’s and Begg’s test was done to check for presence of publication bias. Result: Search of electronic data bases identified 265 studies of which five were included for the final analysis. Majority of the studies have a high methodological quality. The result of pooled estimate showed that the odds of still birth was higher in women who developed maternal near miss than those who deliver without complications (Pooled OR=4.67, 95% CI [2.91-7.47], I2=85.0%). Sub group analysis based on the design of the studies indicated that variation in the design was one of the factors responsible for the observed heterogeneity. The presence of publication bias was not observed from Begg’s and Egger’s test. (Begg’s Test p=0.462 and Egger’s test p=0.637) Conclusion: The study revealed that the odds of still birth are higher in women who developed maternal near miss complications as compared to women without any complications. Hence this evidence will help policy makers in developing countries to design appropriate interventions that will enhance quality of obstetric care for women during pregnancy, delivery and after delivery so as to save the life of babies born from these women.
The role of innovation labs in advancing the relevance of Public Service Media: the cases of BBC News Labs and RTVE Lab

As part of their social function, Public Service Media (PSM) organizations are devoted to innovation. In this context, a number of European PSM outlets have created laboratories based on the implementation of products, services and formats for multiplatform audiences. Our research focused on two case studies: a) BBC News Labs (UK) and b) RTVE Lab (Spain). We applied both quantitative and qualitative methodologies. We used content analysis techniques to examine products generated by the two laboratories between 2013 and 2017, quantifying and classifying each one according to categories related to the type and nature of the innovation. We carried out ethnographic research using participant observation over five days in each laboratory, both in London and Madrid. We also conducted open-ended interviews with five professionals at the BBC and three at RTVE, as well as with the head of EBU’s Media Strategy & Development department. Our results show that BBC News Labs implements a global innovation strategy through the design and engineering of products that facilitate journalists’ work. Projects include speechto- text software, prototypes for voice recognition and text analysis, chatbots and object-based media. On the other hand, RTVE Lab focuses on designing and producing interactive formats, multimedia narratives and social media content, with an emphasis on experimentation. The findings reveal the main barriers and incentives to innovation within each lab and show how the transfer of innovation could increase the diversity, universality and quality of their overall output.
Theoretical and Experimental Study and Design Method of Blade Height of a Rotational-Flow Suction Unit in a Wall-Climbing Robot

A wall-climbing robot that uses a rotational-flow suction unit to be non-contact-absorbed onto walls can climb rough walls and overstep obstacles. In the rotational-flow suction unit, the air driven by the blades rotates at a high speed within a chamber, thereby creating and maintaining a negative pressure distribution. This study is focused on the modeling and design of the blade height. First, a theoretical model of the rotation flow, containing two important parameters (i.e., blade height Hb and clearance h), was established and verified experimentally. Furthermore, the computational fluid dynamics (CFD) method was applied to illustrate the secondary flow relative to the blades, revealing that it gives rise to a nonlinear velocity distribution. It was found that an increase in the blade height greatly improves the F–h characteristics; in addition, the relationship between the power consumption and suction force (E˙−F curve) is mainly determined by the clearance h instead of the blade height Hb. Based on these findings, we propose a design method for determining the suitable blade height. According to the characteristic load curves of the suction units (i.e., the T–ω curves) and the motor characteristics, suitable blades can be selected to match the motor operation (i.e., nominal operating state).
Design and Development of a Quasi-Passive Transtibial Biarticular Prosthesis to Replicate Gastrocnemius Function in Walking.

Lower-limb amputees experience many gait impairments and limitations. Some of these impairments can be attributed to the lack of a functioning biarticular gastrocnemius (GAS) muscle. We propose a transtibial prosthesis that implements a quasi-passive spring mechanism to replicate GAS function. A prototype biarticular prosthesis (BP) was designed, built, and tested on one subject with a transtibial amputation. They walked on an instrumented treadmill with motion capture under three different biarticular spring stiffness conditions. A custom-developed OpenSim musculoskeletal model, which included the BP, was used to calculate the work performed and torque applied by the BP spring on the knee and ankle joints. The BP functioned as expected, generating forces with similar timing to GAS. Work transfer occurred from the ankle to the knee, with stiffer springs transferring more energy. Driven mostly by kinematics, the quasi-passive design of the BP consumed very low power (5.15 W average) and could lend itself well to future lightweight, low-power designs.
New insights in primary ciliary dyskinesia

ABSTRACT Introduction: Primary ciliary dyskinesia (PCD) is a rare genetic disease with an estimated prevalence of 1:20.000 births. It is characterized by abnormal motility of cilia, leading to impaired mucociliary clearance, and subsequent infection and chronic inflammation of the airways. PCD also affects spermatozoa and cilia in the Fallopian tubes, contributing to fertility issues; dyskinesia of embryonic nodal cilia causes a random distribution of the organs. Areas covered: An overview of the history, genetics, clinical manifestations in children and adults, diagnostic tests, treatments, and prognosis are reviewed. We also discuss current research and future prospects of PCD. Expert opinion: As PCD comprises defects in all organs with motile cilia, patients have a variety of clinical manifestations, often characterized by their presence from birth. Because of the non-specific symptoms, PCD is often confused with other diseases such as cystic fibrosis. There is no gold standard diagnostic test and a variety of diagnostic tests are required, including high-speed video analysis and transmission electron microscopy. Reanalysis following primary cultures of the epithelial cells can help to differentiate primary from secondary defects. Despite being a genetic disease, due to the genetic heterogeneity of PCD, gene analysis can currently only explain 65% of the cases. There is no treatment for PCD, and therapeutic options that contribute to the wellbeing of the patients are based on expert opinion.
A deep‐learning‐based computer vision solution for construction vehicle detection

This paper aims at providing researchers and engineering professionals from the first step of solution development to the last step of solution deployment with a practical and comprehensive deep‐learning‐based solution for detecting construction vehicles. This paper places particular focus on the often‐ignored last step of deployment. Our first phase of solution development involved data preparation, model selection, model training, and model validation. Given the necessarily small‐scale nature of construction vehicle image datasets, we propose as detection model an improved version of the single shot detector MobileNet, which is suitable for embedded devices. Our study's second phase comprised model optimization, application‐specific embedded system selection, economic analysis, and field implementation. Several embedded devices were proposed and compared. Results including a consistent above 90% mean average precision confirm the superior real‐time performance of our proposed solutions. Finally, the practical field implementation of our proposed solutions was investigated. This study validates the practicality of deep‐learning‐based object detection solutions for construction scenarios. Moreover, the detailed information provided by the current study can be employed for several purposes such as safety monitoring, productivity assessments, and managerial decision making.
The Effectiveness Of Self Help Group Therapy To Type 2 Diabetic Women With Comorbid Depression

The International Diabetes Federation report indicates that the prevalence of diabetes has reached epidemic levels globally. Comorbid depression often occurs with diabetes, although often not recognized and did not get therapy. The prevalence of depression in women with diabetes is higher than men. Ironically, treatment of depression seems less attention. The self help group therapy is expected to be one form of diabetes management more holistically. This study aim is to identify the effectiveness of group of self help therapy to type 2 diabetic women with comorbid depression. This research is a quasi-experimental study with untreated control group design with pre-test and post- test study. Research subjects were women with type 2 diabetes in public health center Yogyakarta, Indonesia; Aged over 18 who meet the inclusion and exclusion criteria totaling 65 people. The results of this study showed the prevalence of depression in this study is 64,7%. Statistical analysis of the influence of self help group therapy between treatment and control groups showed there were significant differences in changes in Becks Depression Inventory score (p=0.001), and the changes in fasting blood glucose (p=0.002). While the changes in cholesterol levels found no significant difference (p=0.207). Contingency table analysis showed the influence of self help group therapy with improvement of depression with a value of relative risk = 2.08 in the determination of cut-off value of Beck Depression Inventory depression scores < 10 (p=0.003). The results from multivariate analysis showed that variable influences in changing depression scores is self help group therapy (p=0.008). Self help group therapy improves depression and reducing fasting blood glucose levels of type 2 diabetic woman with comorbid depression. Self help group therapy reduces depression 2-fold.
Pharmacy Issues: Chemotherapy

This continuing feature will inform readers about the process of implementing, maintaining, and supporting computerized prescriber order entry (CPOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of CPOE at the Medical Center.
TRATAMENTO DE PERI-IMPLANTITE COM AUXILIO DE ANTIBIOTICOTERAPIA: Relato de caso

Peri-implantite e um processo inflamatorio que ocorre ao redor dos implantes osseointegrados podendo causar a perda do osso alveolar, geralmente as peri-implantites sao antecedidas por periodontites graves em que ocorre a perda do elemento dentario e grave reabsorcao ossea. No seguinte caso, paciente do sexo masculino, melanoderma, com 69 anos de idade, apresentava dor e sangramento na mucosa peri-implantar espontânea e ao higienizar os dentes posteriores da maxila. Paciente parcialmente edentulo com historico de periodontite generalizada com perdas dentarias associadas. O tratamento consistiu-se de antissepsia extra-bucal e intra-bucal, anestesia local, remocao das proteses para posterior limpeza, acesso cirurgico para instrumentacao, irrigacao abundante com soro fisiologico esteril, aplicacao local de gel manipulado de metronidazol 400mg, instalacao de cicatrizadores e sutura com pontos interrompidos, como coadjuvante foi utilizada a antibioticoterapia sistemica com amoxicilina 500 mg associada a metronidazol 250mg. E imperativo a manutencao da saude dos tecidos periodontais e a prevencao de doencas peri-implantares para o sucesso e longevidade das reabilitacoes sobre-implantes, sendo fundamental a atuacao do cirurgiao-dentista no correto diagnostico, selecao do tratamento a ser realizado, baseado em evidencias cientifica de alta qualidade e forca de recomendacao.
The Paradigm of Technological Innovations from Open to Scarless Surgery for Colorectal Cancer

The global burden of colorectal cancer (CRC) and therapeutic evolutions The estimated incidence of colorectal cancer (CRC) is expected to increase by 60% with over 2.2 million new cases and 1.1 million deaths by 2030.1,2 In keeping with this global escalation of CRC, the pedagogy of curative therapies has also been revolutionized. Innovations in bioengineering technologies show tremendous progress in the surgical treatments of CRC with a significant impact on postoperative recovery time, the amount of surgical trauma, and cancer-related morbidity and survival.3 The 4-year disease-free survival for patients with stages IIII CRC has improved to 85.5% following total mesorectal excision.4 The following sections of this paper shed light on the surgical developments for CRC that have accounted for less complications and morbidity, rapid recovery, and improved survival. Surgical m anagement of colorectal cancer (CRC) by laparoscopic and robotic assisted laparoscopic surgery The management of CRC primarily involves a multidisciplinary approach that derives services from a number of disciplines surgery, oncology, radiology, nutrition, and social care.5 The main reason for integrating these disciplines is driven by the fact that the disease quite often presents at an advanced stage which necessitates neo(adjuvant) therapy and nutritional support during the perioperative period.6 Traditionally, the mainstay of CRC treatment is surgical therapy that carries the promise of cure even in the presence of metastases. Before the advent of laparoscopy, all surgical therapies were performed by an open technique with a high incidence of anastomotic leakage,7 wound infection, adhesions and incisional hernia,8 longer hospital stay, and high morbidity.9 In the 1990s, laparoscopic surgery revolutionized the landscape of surgical therapies in all disciplines, ♦Corresponding Author: Salman Yousuf Guraya, FRCS, Masters MedEd Professor of Surgery, Vice Dean, College of Medicine, Clinical Sciences Department, University of Sharjah, UAE Email: salmanguraya@gmail.com Editorial Middle East Journal of Cancer; January 2018; 9(1): 1-4