Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantitative Risk Management under the Interplay of Insurance and Financial Risks

En esta tesis, abordamos algunos problemas relacionados con la interaccion de los riesgos de seguros y financieros. Primero, consideramos una compania de seguros o financiera con la intencion de asignar el capital de riesgo retenido para su cartera de inversion general entre sus constituyentes. Brevemente, suponemos que la compania calcula el capital de riesgo a traves de la medida de riesgo Haezendonck - Goovaerts, y establecemos la regla de asignacion de capital unica consistente con un enfoque RORAR (retorno sobre capital ajustado al riesgo). Ademas, presentamos algunas asintoticas y proponemos un estimador consistente para la regla de asignacion de capital. Finalmente, realizamos algunos estudios numericos. Luego, resolvemos el problema de valorar algunos derivados vinculados a la mortalidad empleando el enfoque de precios de indiferencia de utilidad. De manera sucinta, suponemos que el riesgo de mortalidad emana de una cartera de asegurados de vida, cuyas vidas restantes se modelan como tiempos aleatorios condicionalmente independientes. Al adaptar algunos resultados de la teoria del riesgo de credito, calculamos una expresion explicita para el precio de indiferencia de la utilidad cuando el derivado es una combinacion lineal de dotaciones puras. Al considerar una reclamacion contingente mas general, utilizamos tecnicas de ecuaciones diferenciales estocasticas hacia atras (BSDE) para caracterizar el precio de indiferencia en terminos de una solucion a un BSDE no lineal con un generador no Lipschitz. Finalmente, consideramos a un individuo con el objetivo de elegir de manera optima sus estrategias de inversion, consumo y compra de seguros de vida en un mercado financiero completo. Al suponer que el criterio de optimizacion es la maximizacion de la utilidad esperada del individuo, la cual depende del estado de la economia, resolvemos el problema de eleccion optima en una configuracion general, que incluye varias funciones de utilidad empleadas en la literatura.
Diagnosis and Treatment of Early Chronic Obstructive Lung Disease (COPD)

Chronic obstructive lung disease (COPD) is responsible for substantial rates of mortality and economic burden, and is one of the most important public-health concerns. As the disease characteristics include irreversible airway obstruction and progressive lung function decline, there has been a great deal of interest in detection at the early stages of COPD during the “at risk” or undiagnosed preclinical stage to prevent the disease from progressing to the overt stage. Previous studies have used various definitions of early COPD, and the term mild COPD has also often been used. There has been a great deal of recent effort to establish a definition of early COPD, but comprehensive evaluation is still required, including identification of risk factors, various physiological and radiological tests, and clinical manifestations for diagnosis of early COPD, considering the heterogeneity of the disease. The treatment of early COPD should be considered from the perspective of prevention of disease progression and management of clinical deterioration. There has been a lack of studies on this topic as the definition of early COPD has been proposed only recently, and therefore further clinical studies are needed.
CRITÉRIOS PARA SELEÇÃO DE IDEIAS NO FRONT END DA INOVAÇÃO

Appropriate criteria for selecting ideas increase the chances of organizations to develop potentially innovative and competitive products. The purpose of this paper is to identify criteria for selecting ideas in the context of innovation. For this, an integrative literature review was conducted. The result identified the division of the criteria into 5 aspects. The Technical and Technological aspect encompasses the technical viability, infrastructure and intellectual capital. Economical addresses the market, customer acceptance and finance. The Strategic aspect involves strategic fit. The Social aspect considers the culture and context. Finally, Intuition is considered when choosing ideas in the early stages of innovation.
FATORES DETERMINANTES E CONDICIONANTES PARA INOVAÇÃO E COMPETITIVIDADE NO SETOR DO AGRONEGÓCIO BRASILEIRO

Demand for food in the world, driven by population growth and the inevitable continuity of the urbanization process in developing countries such as China and India, allows us to recognize that Brazil, with its largest expanse of arable land in the world and its wide variety climate and soils, makes agribusiness one of the most important economic sectors. The study conducted in this research uses the qualitative method, descriptive and exploratory, with theoretical approach and based on secondary data, which favors faster access to information by collecting data from the websites of the institutions responsible for monitoring the development of the research sector studied. Despite the many challenges facing the sector in terms of policies and infrastructure, the recent negative impacts of research, such as “The Weak Meat” or the “Super” North American Soybean crop, the agribusiness trade balance still stand out maintains growth rates on a positive trend curve in 2017 compared to 2016. It concluded that after two years in a scenario of economic crisis, agribusiness indicators are favorable for a growth trajectory and with exports that continue to support the trade balance. However, more attention should be paid to the diversification of agribusiness to better protect the Brazilian market.
Diameters and Fluorescence Calibration for Extracellular Vesicle Analyses by Flow Cytometry

Extracellular vesicles (EVs) play a crucial role in the intercellular crosstalk. Mesenchymal stem cell-derived EVs (MSC-EVs), displaying promising therapeutic roles, contribute to the strong rationale for developing EVs as an alternative therapeutic option. EV analysis still represents one of the major issues to be solved in order to translate the use of MSC-EV detection in clinical settings. Even if flow cytometry (FC) has been largely applied for EV studies, the lack of consensus on protocols for FC detection of EVs generated controversy. Standard FC procedures, based on scatter measurements, only allows the detection of the “tip of the iceberg” of all EVs. We applied an alternative FC approach based on the use of a trigger threshold on a fluorescence channel. The EV numbers obtained by the application of the fluorescence triggering resulted significantly higher in respect to them obtained from the same samples acquired by placing the threshold on the side scatter (SSC) channel. The analysis of EV concentrations carried out by three different standardized flow cytometers allowed us to achieve a high level of reproducibility (CV < 20%). By applying the here-reported method highly reproducible results in terms of EV analysis and concentration measurements were obtained.
The relevance of being hypnotic in addressing trauma in children across settings

ABSTRACT Clinical hypnosis has proven effective in the treatment of trauma, not just for adults but for children as well. Given the prevalence of children with trauma and the trauma-related dysregulation evident in school settings, promotion of emotional regulation skills and access to emotional management tools are necessary. Trauma-informed care is on the rise in both medical and academic settings. Some schools are even employing hypnotic-like methods such as meditation with substantial success to address symptoms of dysregulation. Given the suggestibility of children without formal inductions and the ease of which hypnotic-like interventions can be employed, this article will explore how the art of “being hypnotic” and the use of hypnotic language is, and can, be used in various settings, not to treat trauma, but to foster affect regulation, reduce observable distress, improve self-confidence, and promote resilience.
Update on Monogenic Diabetes in Korea

Monogenic diabetes, including maturity-onset diabetes of the young, neonatal diabetes, and other rare forms of diabetes, results from a single gene mutation. It has been estimated to represent around 1% to 6% of all diabetes. With the advances in genome sequencing technology, it is possible to diagnose more monogenic diabetes cases than ever before. In Korea, 11 studies have identified several monogenic diabetes cases, using Sanger sequencing and whole exome sequencing since 2001. The recent largest study, using targeted exome panel sequencing, found a molecular diagnosis rate of 21.1% for monogenic diabetes in clinically suspected patients. Mutations in glucokinase (GCK), hepatocyte nuclear factor 1α (HNF1A), and HNF4A were most commonly found. Genetic diagnosis of monogenic diabetes is important as it determines the therapeutic approach required for patients and helps to identify affected family members. However, there are still many challenges, which include a lack of simple clinical criterion for selecting patients for genetic testing, difficulties in interpreting the genetic test results, and high costs for genetic testing. In this review, we will discuss the latest updates on monogenic diabetes in Korea, and suggest an algorithm to screen patients for genetic testing. The genetic tests and non-genetic markers for accurate diagnosis of monogenic diabetes will be also reviewed.
A qualitative evaluation of the impact of a training programme on colorectal cancer risk reduction for Specialist Screening Practitioners on health promotion, knowledge and practice

Abstract Objective Colorectal cancer (CRC) is the fourth most common cancer in the UK. It is estimated that around 50% of the disease burden is caused by lifestyle factors. This paper evaluates the impact of a training programme for Specialist Screening Practitioners (SSPs) on knowledge of CRC risk reduction and subsequent health promotion activities. Method Attendees (n = 21) were invited to participate in semi‐structured qualitative telephone interviews developed in conjunction with programme organisers. An independent researcher undertook the interviews on the perceived impact of the training on knowledge about risk reduction, communicating health promotion messages and working practices. Results Ten interviews were conducted. The programme was perceived to be successful in increasing knowledge about CRC risk and methods to promote behavioural change. Participants questioned the suitability of the endoscopy setting to communicate health promotion messages given patient anxiety pre‐investigation and post‐investigation elation after negative results. Key barriers to health promotion activities were time, hesitancy over raising issues that could not be easily discussed and scepticism about the ability of older adults to change their lifestyle. Conclusions Training on CRC risk reduction increased knowledge and behaviour change skills among SSPs. Further work is needed to explore opportunities to optimise the screening environment for health promotion activities.
Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma

Background: Amphiregulin (AREG) expression in asthmatic airways and sputum was shown to increase and correlate with asthma. However, no studies were carried out to evaluate the AREG level in blood and saliva of asthmatic patients. Objective: To measure circulating AREG mRNA and protein concentrations in blood, saliva, and bronchial biopsies samples from asthmatic patients. Methods: Plasma and Saliva AREG protein concentrations were measured using ELISA while PBMCs, and Saliva mRNA expression was measured by RT qPCR in non-severe, and severe asthmatic patients compared to healthy controls. Primary asthmatic bronchial epithelial cells and fibroblasts were assessed for AREG mRNA expression and released soluble AREG in their conditioned media. Tissue expression of AREG was evaluated using immunohistochemistry of bronchial biopsies from asthmatic patients and healthy controls. Publicly available transcriptomic databases were explored for the global transcriptomic profile of bronchial epithelium, and PBMCs were explored for AREG expression in asthmatic vs. healthy controls. Results: Asthmatic patients had higher AREG protein levels in blood and saliva compared to control subjects. Higher mRNA expression in saliva and primary bronchial epithelial cells plus higher AREG immunoreactivity in bronchial biopsies were also observed. Both blood and saliva AREG levels showed positive correlations with allergic rhinitis status, atopy status, eczema status, plasma periostin, neutrophilia, Montelukast sodium use, ACT score, FEV1, and FEV1/FVC. In silico analysis showed that severe asthmatic bronchial epithelium with high AREG gene expression is associated with higher neutrophils infiltration. Conclusion: AREG levels measured in a minimally invasive blood sample and a non-invasive saliva sample are higher in non-allergic severe asthma. Clinical Implications This is the first report to show the higher level of AREG levels in blood and saliva of non-allergic severe asthma.
Quenching studies of lattice vacancies in high-purity aluminium

The experimental techniques for obtaining reliable enthalpies of formation and migration of vacancies in pure metals and the importance of achieving high accuracy are critically discussed, with emphasis on studies based on the quenching-in of thermal' vacancies. From measurements of the residual electrical resistance introduced into high-purity Al foils (thickness 0.1 mm) by ultrafast quenches (initial quenching rate 2 x 10 6 K s -1 ) from temperatures T between 800 K and 530 K and the literature data on high-temperature differential dilatometry, the enthalpy, H F 1V = (0.65 ± 0.01) eV, and the entropy, S F 1V = (0.76 ± 0.04)k B (k B = Boltzmann's constant), of monovacancy formation as well as the resistivity ρ 1V = (1.9 ± 0.1) μΩm per unit atomic concentration of vacancies are derived. Combining these results with the Al self-diffusion data deduced from nuclear magnetic resonance leads to the migration enthalpy H M 1V = (0.61 ± 0.02) eV and the pre-exponential factor D 0 1V = 6 x 10 -6 m 2 s -1 of the monovacancy diffusivity D 1V = D 0 1V exp(-H M 1V /k B T). The divacancy binding enthalpy is found to be H B 2V = (0.17 5 ± 0.02 5 ) eV. This is in full agreement with earlier determinations by Doyama and Koehler and by Levy, Lanore and Hillairet, who employed a different technique, but in stark contrast to the recent assertion H B 2V 0 of Carling et al.
Distributed Phase Oscillatory Excitation Efficiently Produces Attractors Using Spike Timing Dependent Plasticity

The brain is thought to represent information in the form of activity in distributed groups of neurons known as attractors, but it is not clear how attractors are formed or used in processing. We show here that in a randomly connected network of simulated spiking neurons, periodic stimulation of neurons with distributed phase offsets, along with standard spike timing dependent plasticity (STDP), efficiently creates distributed attractors. These attractors may have a consistent ordered firing pattern, or become disordered, depending on the conditions. We also show that when two such attractors are stimulated in sequence, the same STDP mechanism can create a directed association between them, forming the basis of an associative network. We find that for an STDP time constant of 20ms, the dependence of the efficiency of attractor creation on the driving frequency has a broad peak centered around 8Hz. Upon restimulation, the attractors selfoscillate, but with an oscillation frequency that is higher than the driving frequency, ranging from 10-100Hz.
Morphological and phylogeographic evidence for budding speciation: an example in hominins

Parametric phylogenetic approaches that attempt to delineate between distinct ‘modes’ of speciation (splitting cladogenesis, budding cladogenesis, and anagenesis) between fossil taxa have become increasingly popular among comparative biologists. But it is not yet well-understood how clearly morphological data from fossil taxa speak to detailed questions of speciation mode as compared to the lineage diversification models that serve as their basis. In addition, the congruence of inferences made using these approaches with geographic patterns has not been explored. Here, I extend a previously introduced maximum-likelihood approach for the examination of ancestor-descendant relationships to accommodate budding speciation and apply it to a dataset of fossil hominins. I place these results in a phylogeographic context to better understand spatial dynamics underlying the hypothesized speciation patterns. The spatial patterns implied by the phylogeny hint at the complex demographic processes underlying the spread and diversification of hominins throughout the Pleistocene. I also find that inferences of budding are driven primarily by stratigraphic, versus morphological, data and discuss the ramifications for interpretations of speciation process in hominins specifically and from phylogenetic data in general.
THE IMPACT OF CARTOON PROGRAMS ON CHILDREN'S PHYSICAL HEALTH, INTELLIGENCE, BEHAVIOR AND ACTIVITIES

The aim of this paper is to illustrate the impact of cartoon programs on children's physical health, intelligence, behavior and activities. The findings of this paper are beneficial to the personnel involved in social science studies, public health studies and especially to those communities who are in charge of practicing physiotherapy and rehabilitation studies. Cartoon programs are both advantageous and disadvantageous to the children’s health and activities. Children learn too many good lessons by watching cartoon programs which directly contribute to the language development, behavioral development and educational development. Furthermore, children become aware about physiotherapy and rehabilitation activities, health activities, medical activities which they directly learn from cartoon programs. Besides, cartoon programs have several destructive influences such as injuries to eyesight and hearing, imagination, superstition, learning to lie, inattentiveness in study and violence those are also illustrated in this paper. Investigation was carried out on several popular cartoon programs and then the information was collected to prepare the manuscript. This paper is practice based and the outcomes are helpful to the scholars involved in cartoon program studies and to work for the improvement of children’s both physical and mental health. This paper opens possible ways for the scholars to further study in this field. Article visualizations:
Antioxidant capacity changes in Chili Spur Pepper (Capsicum annuum Linn. var. acuminatum Fingerh.) during drying process

The antioxidant capacity of chili spur pepper (Capsicum annuum Linn. var. acuminatum Fingerh.) during the drying process at 70, 100, and 121°C, was analyzed by 3 different methods, including Ferric reducing antioxidant power (FRAP) assay, Improved ABTS radical cation decolourization assay and DPPH free radical scavenging activity, together with the analysis of total phenolic content and browning pigment formation. It was found that total phenolic content might decrease at the beginning of the drying process, but would be increased when browning pigments were developed. The decrease of total phenolic content affected the reducing power (FRAP), however, there was no effect on free radical scavenging activities (ABTS and DPPH). This meant the reducing power of chili spur pepper was directly influenced by phenolic compounds both in chili spur pepper and those developed from the browning reaction, whilst its free radical scavenging activities were not only affected by phenolic compounds but also influenced by other compounds developed during the drying process. In addition, it was found that the antioxidant capacity of dried chili spur pepper was dependent on the degree of browning and the drying temperature. The reducing power of dried products might be lower than fresh ones if they were dried at 70°C, but their free radical scavenging activities would be higher than the fresh product.
Design, Synthesis and Characterization of 2,4-Dimethylphenyl Hydrazine based Chemosensors

Hydrazones are a unique division of compounds found in various syntheses. They have an important role in synthetic chemistrydue to their different biological properties, such as antifungal, anticonvulsant, antibacterial, antimalarial, anti-inflammatory and anti-TB properties. This paper reports the syntheses of a series of 3 hydrazones based on the condensation of 2,4-dimethylphenyl hydrazine HCl with different aromatic carbonyl compounds. The structures of the synthesized compounds were confirmed by EIMS. These compounds can act as ideal candidates in chemosensor chemistry.
Implementation of single shot detector for object finding in drone platform

The developing of object detection for many purpose has come to various techniques. Some of those works also implement to solve our daily life problem. Those development which are state-of-the-art are mostly applicable with many pros than others. In this paper we use one of state-of-the-art of object detection to control a quadcopter i.e. Single Shot MultiBox Detector (SSD). SSD is used to detect an object as quadcopter target for approach mission. SSD also use to keep an eye of the target. The target is represented in shape of ROI location. This ROI or a bounding box location is used as feedback of the control system of quadcopter which will guide the quadcopter to approach. The mission is considered as success if the quadcopter is stopped at minimum range 1 meter toward target. This works shows the successful of object detection implementation by serving IMU responses and measured distance to object responses.
Short Communication: Evaluation of 2 implants for growing steers grazing tall-grass prairie when using intensive early stocking

ABSTRACT Commercial implants can have different coating technologies, carriers, and hormone amounts that result in different payout characteristics and effects on cattle growth. Therefore, the objective of this study was to evaluate 2 implants in stocker steers on a 90-d grazing season. Implants were Revalor-G (REV), which contains 40 mg of trenbolone acetate and 8 mg of estradiol, is uncoated, and has a cholesterol carrier, or Synovex One Grass (SYN), which contains 150 mg of trenbolone acetate and 21 mg of estradiol benzoate and has a porous polymer coating. Steers (n = 242) were weighed with an overnight shrink on d 0, 44, and 91. Steers were implanted on d 0 and assigned to 1 of 7 pastures in a completely randomized complete block design with pasture as block. Total gains and gains in each half of the grazing season were evaluated. Average daily gain was not different based on implant type (P = 0.35; 1.16 kg/d for REV and 1.13 kg/d for SYN; SEM = 0.02) nor was total BW gain (P = 0.65; 101 kg for REV vs. 100 kg for SYN; SEM = 2.3). Additionally, BW gain and ADG were not different between implants in both sections of the grazing period (P ≥ 0.45). Overall, cattle performance was not different regardless of hormone amount and coating technology in implants in a short-duration grazing period with stocker steers, and these data do not support a price premium for SYN over REV in this grazing system.