Miracle-dz/UniFAR-FTUs huggingface dataset:
Augmented Reality in Drug Package: a Promising Strategy against Non-adherence in the Treatment of Tuberculosis

Augmented reality is a technology-based on an interaction between the virtual and real-world, mixing them and expanding their possibilities. This technology is currently used in the most varied areas of human knowledge. The use of augmented reality in drug package has excellent potential in several diseases and could be an indispensable tool, especially in diseases with low medication adherence. In this context, its application in tuberculosis treatment could be of great help, as this treatment presents two major issues: the long-term treatment time (six months) and its severe side effects resulting in its non-adherence to the treatment. In this article, we aim to address the problems related to tuberculosis treatment causing non-adherence by using augmented reality. Using a smartphone in the medicine packaging could gain valuable information making patients be aware of following the treatment until the end.
Fake news y redes sociodigitales: cuando la libertad de expresión amenaza la democracia

espanolEl presente ensayo discute los alcances de la desinformacion en las redes sociodigitales y su efecto en los procesos democraticos modernos. Fenomenos como la tirania de la mayoria o la espiral del silencio se reproducen en la era del Big Data y obligan a repensar los limites de la libertad de expresion en pleno siglo XXI. EnglishThis essay put into discussion the scope of misinformation on social networks and its effect on modern democratic processes. Phenomena such as the tyranny of the majority and the spiral of silence are still reproduced in the era of the Big Data, forcing to rethink the boundaries of speech freedom in the twenty-first century.
A 7.4-MHz Tri-Mode DC-DC Buck Converter With Load Current Prediction Scheme and Seamless Mode Transition for IoT Applications

The growth of IoT applications requires DC-DC converters to have small printed circuit board (PCB) areas and high efficiency over a wide load range. A multi-mode operation of DC-DC converters, therefore, is often necessary to achieve this high efficiency over a wide load range. This paper introduces a tri-mode DC-DC buck converter for IoT applications. The tri-mode operation with PWM, PFM, and multiple-sawtooth PWM (MSPWM) modes helps to retain the high efficiency over the wide load range. The MSPWM mode also enhances a noise margin of the converter, ensuring a regular switching operation at an ultra-light load condition. With a load current prediction scheme, the proposed tri-mode converter requires neither additional load current sensor nor multiple mode controllers. In addition, a soft-start operation is employed to prevent an in-rush current. The proposed tri-mode buck converter has been fabricated through a 0.18-<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> CMOS process with a chip area of 0.97 mm <inline-formula> <tex-math notation="LaTeX">$\times0.88$ </tex-math></inline-formula> mm. A load-dependent seamless mode transition is realized, and a maximum converter efficiency of 91% has been measured with a 7.4-MHz switching frequency.
Spectrum of pulmonary disease affecting the persons admitted to respiratory intensive care unit

Aim of the study: To study spectrum of pulmonary disease affecting the persons admitted to respiratory intensive care unit. Results: We observed that mean age of the participants was 51.65 years. The age of participating patients ranged between 30 to 70 years. The number of male subjects was 66 and number of female subjects was 34. We observed that highest number of patients had bronchial asthma (n=22), followed by chronic eempyema (n=19), Pulmonary Tb (n=16), COPD (n=14), Pneumothorax (n=12), pneumonia (n=11). Conclusion: Within the limitations of the present study, it can be concluded that bronchial asthma, chronic eempyema, Pulmonary Tb, COPD and Pneumothorax are most common disease among pulmonary admitted patients.
Microtubules Regulate Spatial Localization and Availability of Insulin Granules in Pancreatic Beta Cells

Two key prerequisites for glucose stimulated insulin secretion (GSIS) in Beta cells are the proximity of insulin granules to the plasma membrane and their anchoring or docking to the plasma membrane (PM). While recent evidence has indicated that both of these factors are altered in the context of diabetes, it is unclear what regulates localization of insulin and its interactions with the PM within single cells. Here we demonstrate that microtubule (MT) motor mediated transport dynamics have a critical role in regulating both factors. Super-resolution imaging shows that while the MT cytoskeleton resembles a random meshwork in the cells’ interior, MTs near the cells surface are preferentially aligned with the PM. Computational modeling demonstrates two consequences of this alignment. First, this structured MT network preferentially withdraws granules from the PM. Second, the binding and transport of insulin granules by MT motors prevents their stable anchoring to the PM. The MT cytoskeleton thus negatively regulates GSIS by both limiting the amount of insulin proximal to the PM and preventing/breaking interactions between the PM and the remaining nearby insulin. These results predict that altering MT structure in beta cells can be used to tune GSIS. Thus, our study points to a potential of an alternative therapeutic strategy for diabetes by targeting specific MT regulators.
The Role of Nuclear Factor Erythroid 2-Related Factors (Nrf2) in Diabetic Neuropathy: A Literature Review

Pain is one of the health problems common in the field of medicine. Complaints of pain themselves are subjective and can affect the quality of life of patients. Therefore, a good understanding is needed to be able to diagnose and treat pain comprehensively. Along with the changing lifestyle in the community, the prevalence of diabetes mellitus (DM) also increased. Diabetic peripheral nerve (DPN) is a complication that often occurs in people with DM. This complication is the most significant cause of morbidity and mortality in patients with DM. Several pathways are thought to have a considerable effect on the incidence of diabetic neuropathy, such as the activation of the polyol pathway from the hexosamine pathway and protein kinase C (PKC), the accumulation of advanced glycation end products (AGEs) in diabetic nerves, excessive levels of glucose and fatty acids. The last few decades of research suggest that there are transcription factors that affect the incidence of diabetic neuropathy will be discussed in this article.
Plating Authenticity in the Eternal City

culinary heritage commodities that would satisfy both the material and intangible aspects of consumption the fungible food itself and the staging of it, desiderata that have come to rival the ruins themselves. ‘Sightseeing is only partial engagement with otherness, whereas culinary tourism, utilizing the sense of taste, smell, touch, and vision, offers a deeper, more integrated level of experience’ (Long, 2004, p.21). These conditions gave rise to the shaping of the ‘template menu’, a basic repertoire of dishes selected for commercial viability which satisfy the gastrotourist’s expectations for authenticity and ease cultural navigation of local culinary offerings. The template menu, the disruption under investigation, can be defined as an artificial construction of a culinary past with supposed historical and cultural pedigree reflecting the timeless customs of locals. This mosaic of menu items is a gastronomic system that has consolidated as ‘standard fare’, representing Roman gastronomy as an identifiable ‘brand’. The establishment of a brand involves consensus – whether tacit or explicit – regarding which items (material culture) characterize the brand and parameters of execution (authenticity). These delineations facilitate packaging, replication, and presentation for food service providers and uncomplicate culinary navigation for tourists (Laudan, 2009). As restaurants are not non-profit organizations, and Rome is heavily reliant on gastro-tourism, chefs/ restaurateurs cannot be indifferent to this frame of reference if they expect to profit from tourism revenues. Every alteration to this menu is a risk that a chef must calculate. It is an interdependent act: customer expectations of ‘authenticity’ are dictated by ‘authoritative’ chefs’ interpretation and execution of the template menu, while at the same time, chefs are locked into adhering to the template menu in order to satisfy customer expectations. This vicious circle homogenizes the cuisine and reduces it to a level of predictability that stymies culinary creativity and retards its evolution. Although the template menu phenomenon is a response to tourist expectations, a collateral effect of successful commodification is culinary mythologizing, willfully assimilated by locals as cultural pride. This posits restaurateurs/chefs, in theory culinary authorities, as the guardians of ‘lost’ foodways, shapers of cultural identity, defenders of authenticity. When commercial profits are yoked to cultural identity against a backdrop of decline or stagnation the edges of historicity are willfully blurred. Therefore, given benefits that cultural trade brings, the culture providers and locals in the circle of pride ‘may perceive an often astonishing Rome in her grandeur – stranger drink your fill. – Propertius
Detection of Extended Spectrum Beta-Lactamases in Escherichia Coli Isolated from the Community in Gaza Strip, Palestine

This study was designed in order to detect the production of extended spectrum beta-lactamase (ESBL) in the isolated Escherichia coli. The prevalence of ESBL production was determined among 300 isolates of E. coli. Eleven (3.7%) isolates proved to be ESBL. High resistance especially, to amoxycillin, cephalexin, cefuroxime, cefotaxime (100.0%) and gentamicin (81.8%) was observed. It was also observed that, all ESBL-producers displayed multiple resistance to four or more antimicrobial agents and the majority of the isolates (36.4%) were resistant to nine agents. Moreover, a highly significant association has been found between infection with ESBL-producers and the patients’ prior antimicrobials use, previous hospitalization and preceding UTI.
Genome-Wide Patterns of Population Structure and Linkage Disequilibrium in Farmed Nile Tilapia (Oreochromis niloticus)

Nile tilapia (Oreochromis niloticus) is one of the most produced farmed fish in the world and represents an important source of protein for human consumption. Farmed Nile tilapia populations are increasingly based on genetically improved stocks, which have been established from admixed populations. To date, there is scarce information about the population genomics of farmed Nile tilapia, assessed by dense single nucleotide polymorphism (SNP) panels. The patterns of linkage disequilibrium (LD) may affect the success of genome-wide association studies (GWAS) and genomic selection and can also provide key information about demographic history of farmed Nile tilapia populations. The objectives of this study were to provide further knowledge about the population structure and LD patterns, as well as, estimate the effective population size (Ne) for three farmed Nile tilapia populations, one from Brazil (POP A) and two from Costa Rica (POP B and POP C). A total of 55, 56 and 57 individuals from POP A, POP B and POP C, respectively, were genotyped using a 50K SNP panel selected from a whole-genome sequencing (WGS) experiment. Two principal components explained about 20% of the total variation and clearly discriminated between the three populations. Population genetic structure analysis showed evidence of admixture, especially for POP C. The contemporary Ne values calculated based to LD values, ranged from 71 to 141. No differences were observed in the LD decay among populations, with a rapid decrease of r2 when increasing inter-marker distance. Average r2 between adjacent SNP pairs ranged from 0.03 to 0.18, 0.03 to 0.17 and 0.03 to 0.16 for POP A, POP B and POP C, respectively. Based on the number of independent chromosome segments in the Nile tilapia genome, at least 4.2 K SNP are required for the implementation of GWAS and genomic selection in farmed Nile tilapia populations.
Power Source Based on Electric Field Energy Harvesting for Monitoring Devices of High-Voltage Transmission Line

This article proposes a power source based on alternating electric field energy harvesting, which can be used for the condition monitoring devices for a high-voltage (HV) transmission line. The energy-harvesting ability of online and offline harvesters depending on different sizes and installation positions is studied herein through a finite-element simulation. The power source uses a novel energy conversion circuit with a cascaded ladder-type topology that can multiply the power when increasing the number of cascaded stages. We set up an HV experiment platform to test the performances of the energy harvester and the power source. The energy-harvesting ability of the harvester approaches the simulation results. The tested power source with four cascaded stages demonstrates a harvesting ability of 620 μW/μA, making it superior to the reported solutions in previous studies. The proposed circuit shows the latent capability of realizing a higher power density.
Members of the Arabidopsis auxin receptor gene family are essential early in embryogenesis and have broadly overlapping functions

The TIR1/AFB proteins are auxin co-receptors that mediate diverse responses to the plant hormone auxin. The genome of Arabidopsis encodes six TIR1/AFB proteins representing three of the four clades that were established prior to angiosperm radiation. To determine the role of these proteins in plant growth and development we have performed an extensive genetic analysis involving the generation and characterization of all combinations of multiply mutant lines. We find that loss of all six proteins results in defects in embryogenesis as early as the first division of the apical cell. Mutant embryos progress, but exhibit frequent errors in cell division and proliferation of the suspensor. Despite this dramatic phenotype, a single wild-type allele of TIR1 or AFB2 is sufficient to support growth of the plant throughout vegetative
Defect-Oriented Test: Effectiveness in High Volume Manufacturing

This article describes a defect-oriented test (DOT) approach, which enables a complete physical defect-based automatic test pattern generation (ATPG) for the digital logic area of CMOS-based designs. Total critical area (TCA)-based methods are presented for the generation of needed DOT views to enable the generation of complete DOT-based patterns for detecting all cell-internal and as well all cell-external physical defects. The major aim of these new methods and patterns is to further reduce the defect rate of manufactured ICs, in addition to what is already achieved with traditional and cell-aware test (CAT) fault models. We present test results, including achieved defect rate reduction in defective parts per million (DPPM), from a large 14-nm FinFET design, including a correlation to system-level-test (SLT) fails. For a second, mature 160-nm automotive mixed-signal sensor we present high-volume production test results, again measured in DPPM, and we provide test coverage figures moving away from counting detected faults to calculating detected TCA which is reported as the chip level TCA coverage.
Receiver Current-Stress Mitigation for a Dynamic Wireless Charging System Employing Constant Resistance Control

The voltage stress of compensation capacitors in the wireless charging system could be up to several kilovolts. Things get worse for the dynamic operating condition because the resonant current gets fluctuating with the rigid variations of the coupling condition. In this article, a constant resistance (CR) control scheme on a boost converter is proposed to mitigate receiver current stress, i.e., the peak currents in the resonant tank and the boost chopper inductor. The receiver-side dynamic wireless charging (DWC) system with a postregulated boost converter is introduced by the static operating waveforms. To investigate how speed affects current stress, a receiver-side current analytical model is established based on the closed-loop input admittance of boost and the dc circuit model of resonant tanks. The modeling results illustrate that the overstress problem is prone to occur at high-speed condition under constant current charging control. CR control, which shapes boost input current and voltage in phase, is adopted to address this problem. Comparative studies for full-range speeds and nonideal coupling conditions, conducted by the DWC simulator, show that uniform low-stress performance is obtained under CR control with the same amount of energy transferred. Maximum stress improvement on the receiver resonant current is 29% for ideal condition and 44% for a nonsinusoidal condition when driving at 80 km/h.
Motivational Typology of Online Food Souvenir Shoppers and Their Travel-Related Intentions

Online shopping has tremendous growth nowadays. Concerns about whether people perceive food souvenirs as commercial goods or products with local connections arise when shopping online for those souvenirs. Another concern is whether people remain interested in knowing or visiting places where food souvenirs originate even if they can simply purchase food souvenirs online. These issues are important for the sustainable development of local tourism. This study aims to investigate consumers’ motivations for purchasing food souvenirs online and whether differences exist between segmented consumers in relation to their travel-related intentions. Participants of this work are individuals who have purchased food souvenirs online and are aged 18 years old or above. Social media applications, such as Facebook and Line, were utilized as the platforms for the questionnaire survey. Participants’ motivations for purchasing food souvenirs online included five factors: exploring trends, local affiliations, social interactions, frugal sampling, and enforcing relationships. According to their motivations, participants were segmented into four types of consumers, including pleasure reminiscers (47.0%), journey recallers (22.9%), economical tasters (17.4%), and social practicers (12.7%). Pleasure reminiscers have stronger intentions toward searching for information on, traveling to, and recommending the places where food souvenirs originate compared with the other three types of consumers. On the basis of the findings, suggestions for the design and marketing of food souvenirs are provided for the producers of food souvenirs and promoters of local tourism.
Joint Resource and Trajectory Optimization for Security in UAV-Assisted MEC Systems

Unmanned aerial vehicle (UAV) has been widely applied in internet-of-things (IoT) scenarios while the security for UAV communications remains a challenging problem due to the broadcast nature of the line-of-sight (LoS) wireless channels. This article investigates the security problems for dual UAV-assisted mobile edge computing (MEC) systems, where one UAV is invoked to help the ground terminal devices (TDs) to compute the offloaded tasks and the other one acts as a jammer to suppress the vicious eavesdroppers. In our framework, minimum secure computing capacity maximization problems are proposed for both the time division multiple access (TDMA) scheme and non-orthogonal multiple access (NOMA) scheme by jointly optimizing the communication resources, computation resources, and UAVs’ trajectories. The formulated problems are non-trivial and challenging to be solved due to the highly coupled variables. To tackle these problems, we first transform them into more tractable ones then a block coordinate descent based algorithm and a penalized block coordinate descent based algorithm are proposed to solve the problems for TDMA and NOMA schemes, respectively. Finally, numerical results show that the security computing capacity performance of the systems is enhanced by the proposed algorithms as compared with the benchmarks. Meanwhile, the NOMA scheme is superior to the TDMA scheme for security improvement.
Using oak silviculture to reintroduce American chestnut

Throughout much of American chestnut's range, the tree co-occurs with various species of oak, commonly northern red and chestnut oak. Oaks benefited from the loss of chestnut, by taking advantage of the increased light and growing space made available when its once abundant cousin was largely extirpated (Wang and Hu 2015). More recent changes in oak-dominated forests, such as increased herbivory and alteration to disturbance regimes, however, threaten the continued dominance of these species (Dey 2014). Because of this, promotion of oak regeneration is now a predominant focus of silviculture research and management, particularly on public lands, throughout the oak-hickory (formerly oak-chestnut) forest type. It would be practical, logistically and financially, then, if the silvicultural strategies used to regenerate oak can also be used to facilitate American chestnut reintroduction.
Clinical Efficacy of Nimodipine and Edaravone Combination in the Treatment of Acute Cerebral Hemorrhage

To observe and analyze the clinical efficacy of nimodipine and edaravone combination in the treatment of acute cerebral hemorrhage, a total of 180 patients definitely diagnosed as acute cerebral hemorrhage and treated in Shandong Jiyang Public hospital were enrolled. The patients were divided into the control group and the research group with 90 patients in each group. Of those, patients of the control group were treated with edaravone, while a combination of nimodipine and edaravone was administered to patients in the research group. Therapeutic efficacy, neurologic impairment score, life quality score, hematoma volume and edema volume were compared between both the groups. Results obtained showed that the total therapeutic efficacy of the research group was better than that of the control group (P<0.05). Measurement of patients’ hematoma volume and edema volume before and after treatment indicated that the research group after drug administration demonstrated significant improvement over the control group (P<0.05). Moreover, there was a greater decrease in the neurologic impairment score of the research group than that of the control group (P<0.05). Combination of nimodipine and edaravone in the treatment of acute cerebral hemorrhage achieved better outcomes indicating greater therapeutic efficacy.
Fun or Frustration: Modelling Discontinuance Intention of Social Media Users

Excessive usage of social network services (SNS) can lead to exhaustion and frustration, which, in turn, can induce SNS discontinuance intention. In this study, the negative factors when using SNS are empirically tested. We constructed a research model that explores the effects of social overload, disclosure, and pattern of SNS use on SNS-induced exhaustion and frustration. We also examined the influence of exhaustion and frustration on SNS discontinuance intention. An empirical study of 170 SNS users from Bangladesh provides support for our hypotheses. Partial least squares algorithm is implemented to test the hypotheses. The result reveals significant influence of frustration on SNS discontinuance intention. The paper contributes by identifying several factors. Both theoretical and practical implications are discussed.
AIR QUALITY MONITORING USING SENSING DEVICES IN URBAN CITY

Motivated by the expansion of air contamination, we watch the properties of air has procured consideration in theoretical investigation and practical execution. Here, we present the architecture, implement, improve the quality for air sensing system, which will be providing current and close-grain air attribute map of the observed area. The aim is to reduce the mean error of current-time air quality map established involving data assumption of the unmeasured values