Miracle-dz/UniFAR-FTUs huggingface dataset:
NBA sweet spots: Distance-based impacts on establishment-level sales

This paper examines distance‐based effects of the introduction of a National Basketball Association (NBA) team on establishment‐level sales. Using a unique micro dataset with precise geographic location information and industry detail, we apply spatio‐temporal estimation strategies following Harger et al. and Ahlfeldt and Kavetsos. We build on the literature by focusing on sales activity, a broad measure of economic activity, for industries related to the NBA‐product. Our application considers the relocation of the NBA’s Seattle franchise (Supersonics) to Oklahoma City (Thunder). The results reveal spatially differentiated impacts that would be obscured using data aggregated over space or industry. Specifically, food establishments exhibit increased sales and entertainment establishments exhibit decreased sales relative to establishments in the outer most ring of the study area.
Azathioprine in Ulcerative Colitis: Final Report on Controlled Therapeutic Trial

Eighty patients, all of whom were suffering from a frank clinical attack of ulcerative colitis, were admitted to the trial. The attack was treated with a standard course of corticosteroids and the patients were immediately placed on treatment with either azathioprine in a dose of 2·5 mg/kg body weight or dummy tablets. The trial tablets were continued for one year while the patients were maintained under regular clinical, sigmoidoscopic, histological, haematological, and biochemical surveillance. If a patient relapsed during such maintenance treatment he or she was treated with a further course of corticosteroids without interrupting maintenance treatment. In the treatment of an actual attack of ulcerative colitis the results in the attacks which brought the 80 patients into the trial show that no benefit came from the addition of azathioprine to a standard course of corticosteroid therapy. Patients admitted in their first attack of ulcerative colitis showed no benefit from the one-year maintenance treatment with azathioprine, the benefits of which were confined to patients admitted in a relapse of established disease. Even in these the difference between the treated group and the control group failed to reach statistical significance, but the difference was big enough to suggest that there is a prima facie case for regarding azathioprine as of some benefit in this group of patients.
NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

Nonalcoholic steatohepatitis (NASH) is often linked with disorders that are clearly associated with insulin resistance (IR): obesity, type 2 diabetes mellitus, and hypertriglyceridemia. We tested the hypotheses that (1) IR is an essential requirement for the development of NASH and (2) a high association between IR and liver disease is relatively specific for NASH. We measured body mass index (BMI), waist/hip ratio, and fasting serum lipid, insulin, C‐peptide, and glucose levels in 66 patients with NASH (21 with advanced fibrosis and 45 with mild fibrosis). IR was determined by the homeostasis model assessment (HOMA). We also determined the strength of the association of NASH with insulin resistance syndrome (IRS) as defined by World Health Organization criteria. To assess whether the finding of IR was relatively specific to NASH rather than simply to obesity or liver disease, we compared the results of a subset of 36 patients with less‐severe NASH with 36 age‐ and sex‐matched patients with chronic hepatitis C virus (HCV) of comparable fibrotic severity. IR was confirmed in 65 patients (98%) with NASH, and 55 (87%) fulfilled minimum criteria for IRS. IR was found in lean as well as in overweight and obese patients. The IR values and the prevalence of IRS (75% vs. 8.3%) were significantly higher in those with NASH than in comparable cases of HCV. Hyperinsulinemia was attributable to increased insulin secretion rather than decreased hepatic extraction. In conclusion, most patients with NASH have IRS, and there is a near‐universal association between NASH and IR irrespective of obesity. IR is present in mild as well as advanced cases of NASH but is unusual in chronic HCV of similar fibrotic severity.
Simulation study and implementation of the tests based on weighted Turnbull's estimators for interval-censored data.

Several tests for comparing k groups of interval-censored data based on Turnbull's estimator of a survival function are compared by a Monte Carlo simulation study. The tests under consideration include the IWD test proposed by Petroni and Wolfe, the score test derived by Finkelstein, and a logrank type test suggested by Sun. With a large sample size and in a two-sample comparison, simulation results suggest that the IWD test is applicable for early and crossing hazard difference alternatives, whereas Finkelstein's score test, Sun's test and the logrank test are slightly more powerful than the IWD tests under late hazard difference alternatives. The IWD test is designed for the two-sample testing problem. With a large sample size and in a k-sample comparison, Finkelstein's score test is slightly better than the other tests under a proportional hazards model, while Sun's test and the logrank test are slightly better than the score test under early and crossing hazard difference alternatives. However, none of the test statistics is uniformly better than the others for the alternatives considered in this paper with both non-overlapping and overlapping interval-censored data.
An online hybrid BCI system based on SSVEP and EMG

Objective. A hybrid brain-computer interface (BCI) is a device combined with at least one other communication system that takes advantage of both parts to build a link between humans and machines. To increase the number of targets and the information transfer rate (ITR), electromyogram (EMG) and steady-state visual evoked potential (SSVEP) were combined to implement a hybrid BCI. A multi-choice selection method based on EMG was developed to enhance the system performance. Approach. A 60-target hybrid BCI speller was built in this study. A single trial was divided into two stages: a stimulation stage and an output selection stage. In the stimulation stage, SSVEP and EMG were used together. Every stimulus flickered at its given frequency to elicit SSVEP. All of the stimuli were divided equally into four sections with the same frequency set. The frequency of each stimulus in a section was different. SSVEPs were used to discriminate targets in the same section. Different sections were classified using EMG signals from the forearm. Subjects were asked to make different number of fists according to the target section. Canonical Correlation Analysis (CCA) and mean filtering was used to classify SSVEP and EMG separately. In the output selection stage, the top two optimal choices were given. The first choice with the highest probability of an accurate classification was the default output of the system. Subjects were required to make a fist to select the second choice only if the second choice was correct. Main results. The online results obtained from ten subjects showed that the mean accurate classification rate and ITR were 81.0% and 83.6 bits min−1 respectively only using the first choice selection. The ITR of the hybrid system was significantly higher than the ITR of any of the two single modalities (EMG: 30.7 bits min−1, SSVEP: 60.2 bits min−1). After the addition of the second choice selection and the correction task, the accurate classification rate and ITR was enhanced to 85.8% and 90.9 bit min−1. Significance. These results suggest that the hybrid system proposed here is suitable for practical use.
A new locus for autosomal dominant generalized epilepsy associated with mild mental retardation on chromosome 3p

Purpose: Generalized epilepsies are clinically and genetically heterogeneous syndromes. Idiopathic generalized epilepsy (IGE), which has a strong genetic background, is not associated with any additional clinical features, such as mental retardation (MR). Herein we report results of linkage analysis in a large family with autosomal dominant (AD) generalized epilepsy associated with MR.
Factors that influence passive transfer of immunoglobulins in foals.

Effects of farm management, breed, mare age, gestation duration, and climatologic factors on colostral specific gravity, colostral IgG concentration, and foal serum IgG concentration were evaluated. Climatologic variables measured were daily maximal, minimal, and mean air temperature, precipitation, average relative humidity, and total solar radiation. Presuckle, postpartum colostrum samples were collected from 140 Standardbred, 94 Thoroughbred, and 59 Arabian mares from January through June during 1985 and 1986. Thoroughbred (farm A, n = 61; farm B, n = 33) and Arabian (farm C, n = 45; farm D, n = 14) mares were located in Ocala, Fla; Standardbred mares (farm E) were in Montgomery, NY. Mares from farms A, B, D, and E foaled in box stalls, and mares from farm C foaled in sand paddocks. Mares with premature lactation greater than 12 hours were not included in the study. Foals were clinically normal at birth and suckled colostrum without assistance within 2 hours of parturition. Specific gravity of presuckle colostrum samples was measured by use of an equine colostrometer. Blood samples were collected 18 hours after parturition from 253 of the 293 foals (n = 45, 25, 32, 13, 138 on farms A through E, respectively) to determine serum concentration of IgG. The IgG concentrations in colostrum and serum were measured by single radial immunodiffusion. Data were analyzed by multiple regression or chi 2 analysis. The most important determinants of foal serum IgG concentration were the IgG content and specific gravity of presuckle colostrum samples (P less than 0.0001). (ABSTRACT TRUNCATED AT 250 WORDS)
Clinical Results of Arthroscopic Single-Bundle Transtibial Posterior Cruciate Ligament Reconstruction

Background: Reconstruction of the posterior cruciate ligament has traditionally been performed using an arthroscopically assisted single-bundle transtibial technique. Unfortunately, clinical studies evaluating this procedure are rare. In addition, there are no pooled analyses evaluating the effectiveness of this procedure for isolated posterior cruciate ligament tears. Hypothesis: Patients who undergo arthroscopically assisted, single-bundle, transtibial posterior cruciate ligament reconstruction will exhibit subjective improvement in knee function despite persistent objective knee laxity. Study Design: Systematic review. Methods: A structured literature search was performed to identify those clinical studies assessing the results of an arthroscopically assisted single-bundle transtibial posterior cruciate ligament reconstruction for isolated posterior cruciate ligament tears. The published data meeting the inclusion criteria were systematically reviewed with an emphasis on residual posterior laxity, subjective and objective functional outcome, activity level, patient satisfaction, incidence of osteoarthritis, and postoperative complications. Results: A total of 10 studies were identified that met the inclusion criteria. Mean postoperative instrumented posterior knee laxity varied from 1.96 mm to 5.90 mm, which was considerably improved from preoperative values (range, 8.38-12.3 mm). The range of mean values of the Lysholm knee scores was 81 to 100 points. The overall International Knee Documentation Committee rating was categorized as “normal” or “nearly normal” in 75% of patients and the mean Tegner activity score varied from 4.7 to 6.3 points. Degenerative osteoarthritis was frequently noted at the time of the most recent follow-up. There were few complications reported. Conclusion: Arthroscopically assisted single-bundle transtibial posterior cruciate ligament reconstruction for isolated posterior cruciate ligament tears can improve posterior knee laxity by 1 grade, although this procedure does not reliably restore normal knee stability. Return to recreational and athletic activity was predictable, with 75% of patients exhibiting a normal or nearly normal objective outcome, although degenerative osteoarthritis was not prevented by this procedure.
Quantitative analysis of retinopathy in type 2 diabetes: identification of prognostic parameters for developing visual loss secondary to diabetic maculopathy.

PURPOSE To describe whether quantitative assessment of early changes in the morphology of retinopathy lesions can predict development of vision-threatening diabetic maculopathy. METHODS We used a nested case-control study, and we studied 11 type 2 diabetes patients who had developed visual loss secondary to diabetic maculopathy. For each diabetes patient, we also studied three matched control patients who had been followed for a comparable period of time without developing visual loss. Fundus photographs describing the early development of retinopathy were digitized and subjected to a full manual quantitative grading on a computer monitor. Differences in the early development of retinal morphology were compared between the two groups. The outcome parameters were changes in the number and area of haemorrhages and exudates in different regions of the fundus, and the weighted distance of these lesions from the fovea and the optic disc. RESULTS In patients who developed visual loss secondary to diabetic maculopathy there was significant early progression in the total area and number of haemorrhages and exudates. The haemorrhages had progressed in all retinal areas except the area around the optic disc and the temporal vascular arcades. The exudates had progressed temporally from the fovea and in the retinal periphery. CONCLUSIONS The results suggest that a quantitative description of the regional development of early diabetic retinopathy may help in identifying patients who will later develop vision-threatening maculopathy.
Intradiscal Pressure Changes With Dynamic Pedicle Screw Systems

Study Design In vitro study using porcine spines instrumented with pedicle screw and rod fixation. Objectives To determine the intradiscal pressure (IDP) changes with the use of dynamic and rigid pedicle screw systems in simulated spinal fusion. Summary of Background Data The intervertebral discs are prone to injury under conditions of altered IDP. The effects of instrumentation with dynamic pedicle screw systems on IDP have not been clearly delineated. Methods A 2-level posterior instrumentation was applied to fresh porcine spinal segments (n=16). Dynamic and rigid pedicle screw constructs along with uninstrumented (n=6) spinal segments as controls were tested. The spinal segments were subjected to 24,000 cycles of flexion compression loading at 5 Hz. IDP within the instrumented (L2-L3 and L3-L4) and adjacent (L1-L2 and L4-L5) discs were measured using a pressure transducer needle. Results were recorded at 6000 cycle intervals. Results Instrumentation increased IDP. Within the instrumented levels, the greatest increase in IDP was found at the L2-L3 disc. Here, after 24,000 loading cycles, IDP for spines instrumented with mobile screws was 6.8 times higher than that of uninstrumented spines whereas for rigid screws the factor was 9.1. For the L3-L4 cases, the presence of instrumentation increased IDP by factors of 1.7 and 2.7 for mobile and rigid screws, respectively. In the uninstrumented levels, IDP at L1-L2 and L4-L5 was lower with mobile screws. These were statistically significant at for L1-L2 (24,000 cycles, P=0.008) and L4-L5 level (12,000, 18,000, and 24,000 cycles, P<0.04 in all cases). Conclusions Of the 2 types, mobile screws produced the least increase in IDP. This feature might be beneficial for the fusion process while at the same time prevent secondary pathology such as premature disc degeneration and facet joint pathology due to excessive disc pressures.
Comparison of valsartan and amlodipine on ambulatory blood pressure variability in hypertensive patients

ABSTRACT We tested the hypothesis that calcium channel blockers (CCBs: amlodipine group, n = 38)) are superior to angiotensin receptor blockers (ARBs: valsartan group, n = 38) against ambulatory blood pressure variability (BPV) in untreated Japanese hypertensive patients. Both drugs significantly reduced ambulatory systolic and diastolic BP values. With regard to BPV, standard deviation (SD) in SBP did not change with the administration of either drug, but the ARB significantly increased SD in awake DBP (12 ± 4–14 ± 4 mmHg). The ARB also significantly increased the coefficients of variation (CVs)in awake and 24-h SBP/DBP (all P < 0.05), but amlodipine did not change the CV. CCB significantly reduced the maximum values of awake SBP (193 ± 24–182 ± 27 mmHg, P = 0.02), sleep SBP (156 ± 18–139 ± 14 mmHg, P < 0 .001), and awake and sleep DBP (P < 0.01 in both cases), but the ARB did not change the maximum BP values. In conclusion, a once-daily morning dose of CCB amlodipine was more effective at controlling ambulatory BPV than ARB valsartan, especially in reducing maximum BP levels.
Founding Family and Auditor Choice: Evidence from Taiwan

Research Question/Issue From an agency perspective, we investigate whether family ownership and control configurations are systematically associated with a firm's choice of auditor. Our analysis focuses on three different characteristics of family ownership and control: family ownership (cash flow rights), disparity between cash flow and voting rights held by family owners (cash–vote divergence), and the family identities of CEOs. Research Findings/Insights Our findings suggest that different family ownership and control configurations lead to different agency effects. The alignment effect prevails in family firms with greater family ownership, founder CEOs, and professional CEOs, whereas the entrenchment effect prevails when there is greater cash–vote divergence. Despite the presence of two distinct types of agency effects, regardless of differences in family ownership and control configurations, none of these firms are inclined to appoint higher-quality auditors. Theoretical/Academic Implications This study advances our understanding of the varied agency effects arising from family ownership, cash–vote divergence, and the family identities of CEOs, as well as the impact of family ownership and control features on auditor choice. Our empirical evidence provides a unique insight, showing that higher-quality auditors do not tend to be appointed in firms where family alignment with outside investors is relatively strong, as this lowers demand for such auditors. In addition, although family entrenchment may create greater outside investor demand for higher-quality auditors, such demand is difficult to realize. Practitioner/Policy Implications Auditors are an important external governance mechanism. This study offers insights for policy makers, family owners, auditors, and other capital market participants, with regard to the varied effects of different family ownership and control features on auditor choice.
Family Medicine in the Research Revolution

National Institutes of Health (NIH) funding has contributed to improvements in the health of the nation, but the pace of progress, particularly in the war on cancer, has been frustratingly slow. Departments of family medicine receive less NIH funding than all other specialties. Although numerous factors contribute to low family medicine funding levels, persistent undervaluing of primary care plays a paramount role. Fueled by the harsh reality that our nation's health is unconscionably poor, we are entering a new era in our nation's research enterprise, a virtual research revolution. The 3 components of this revolution are the NIH roadmap, personalized medicine, and the Clinical and Translational Science Awards. Each of these elements will contribute to a growing emphasis on translational research. Translational research demands formation of innovative structures in academic health centers (AHCs) to enable them to address questions of vital relevance to improving public health. Service research, funded by the Agency for Healthcare Research and Quality, the Centers for Disease Control and Prevention, and foundations, defines a new approach to research with high potential to improve the health of communities. To be a part of the research revolution, departments must rely on senior researchers to secure funding and provide mentorship for junior investigators. Junior investigators must relentlessly pursue answers to questions of direct relevance to improving health. Finally, department chairs have the obligation to identify research mentors, find ways to fund research gaps, and create a culture of scholarship and investigation. Advocating for AHCs to commit to improving the health of the regions they serve can have a substantial impact on the types of questions that centers choose to study and, ultimately, on the health of the communities they serve.
Lessons from rare maladies: leukocyte adhesion deficiency syndromes

Purpose of reviewThe leukocyte adhesion deficiency (LAD) syndromes are rare genetically determined conditions with challenging clinical features. These immunodeficiencies also provide insights that are broadly relevant to the biology of leukocytes, platelets, intercellular interactions, and intracellular signaling. Recent discoveries merit their review in the context of existing knowledge. Recent findingsNew activities of &bgr;2 integrins, which are deficient or absent in LAD-I, and new &bgr;2 integrin-dependent functions of neutrophils and other leukocytes have recently been identified. Genetic defects and mechanisms accounting for impaired fucosylation of selectin ligands and defective selectin binding and signaling in LAD-II are now apparent. LAD-III, which presents with bleeding similar to that in Glanzmann thrombasthenia and platelet dysfunction in addition to impaired leukocyte adhesion, is now known to be due to absence of KINDLIN-3, a cytoplasmic protein that acts cooperatively with TALIN-1 in activating &bgr;1, &bgr;2, and &bgr;3 integrins. Understanding of the leukocyte adhesion cascade and interactions of leukocytes with inflamed endothelium, which are impaired in each of the LAD syndromes, continues to be refined. SummaryAlthough LAD syndromes are rare maladies, their investigation is generating new knowledge directly applicable to the diagnosis and care of patients and to fundamental paradigms in immunobiology and hemostasis.