Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficiency of hydrolyzed brewery yeast (Progut®) in weaned piglet's diet

Two groups of weaned piglets (N=46), crossbreed (SLxLW) x Pietrain, the same sex proportions, aged 28 days were involved in the investigation. Piglets from all groups were fed on feed mixture for weaned piglets with 22% of crude protein and 13.84 MJ ME/kg until 21st day of the trial and with 19% of crude protein and 13.74 MJ ME/kg until 35th day of the experiment. The experimental group was added 0.2% Progut® in the feed mixture, during the whole experimental period. Body weight, haematological and some biochemical parameters were determined 7th, 21st and 35th day of the trial. No significant differences were determined in average body mass and concerned biochemical parameters (glucose, creatinine, triglycerides, total protein, albumin, globulin, haptoglobin, C-reactive protein). Total leukocytes count was higher (P>0.05) in the experimental group (E) 21st and 35th day, but significantly higher (P<0.01) share of lymphocytes. We found positively strong correlation between total protein and globulin (r=0.86) in the experimental group, and strong positively correlation (r=0.84) between total protein and albumin in the control group. Significantly (P<0.05) strong negative correlation between triglyceride and total protein concentration (r=-0.83), and triglyceride and globulin concentration (r=-0.90) were determined in the experimental group of piglets. Dietary addition of hydrolyzed brewery yeast influenced both cellular and humoral immune response.
Poly(ADP-ribose) Polymerase Null Mouse Cells Synthesize ADP-ribose Polymers*

Poly(ADP-ribose) polymerase (PARP) (EC 2.4.2.30), the only enzyme known to synthesize ADP-ribose polymers from NAD+, is activated in response to DNA strand breaks and functions in the maintenance of genomic integrity. Mice homozygous for a disrupted gene encoding PARP are viable but have severe sensitivity to γ-radiation and alkylating agents. We demonstrate here that both 3T3 and primary embryo cells derived from PARP−/− mice synthesized ADP-ribose polymers following treatment with the DNA-damaging agent,N-methyl-N′-nitro-N-nitrosoguanidine, despite the fact that no PARP protein was detected in these cells. ADP-ribose polymers isolated from PARP−/− cells were indistinguishable from that of PARP+/+ cells by several criteria. First, they bound to a boronate resin selective for ADP-ribose polymers. Second, treatment of polymers with snake venom phosphodiesterase and alkaline phosphatase yielded ribosyladenosine, a nucleoside diagnostic for the unique ribosyl-ribosyl linkages of ADP-ribose polymers. Third, they were digested by treatment with recombinant poly(ADP-ribose) glycohydrolase, an enzyme highly specific for ADP-ribose polymers. Collectively, these data demonstrate that ADP-ribose polymers are formed in PARP−/− cells in a DNA damage-dependent manner. Because the PARP gene has been disrupted, these results suggest the presence of a previously unreported activity capable of synthesizing ADP-ribose polymers in PARP−/− cells.
Experimental tooth movement into bone induced by recombinant human bone morphogenetic protein-2.

OBJECTIVE The development of biomaterials for secondary bone grafting to the alveolar cleft, recombinant human morphogenetic protein-2 (rhBMP-2) may have great potential to promote osseous regeneration. The purpose of this study was to investigate the osteoinductive activity of low-dose rhBMP-2 (10 microg/100 microL) and the biological response of newly generated bone to orthodontic stimulation, compared with previous results using high-dose rhBMP-2 (40 microg/100 microL). METHOD After extraction of the maxillary first premolars, bone defects were surgically created in eight adult beagle dogs using a 5-mm-diameter trepan bar. The rhBMP-2 with a PLGA/gelatin sponge complex (PGS) made of gelatin and polylactic acid polyglycolic acid copolymer was immediately implanted. The osteoinductive activity of rhBMP-2 and tooth movement into the newly generated bone was evaluated based on histological and morphometric examination. RESULTS Dramatic histological and morphometric differences were found in the time course of bone remodeling between low- and high-dose rhBMP-2. The onset of bone remodeling occurred significantly earlier in low-dose rhBMP-2. During experimental tooth movement, in contrast to high-dose rhBMP-2, with which root resorption occurred, only partial cementum resorption occurred on the pressure side with low-dose rhBMP-2. CONCLUSION These results indicated that the proper dosage of rhBMP-2 should be determined for successful clinical application.
A pseudo-pipelined VLSI architecture of two elliptic curve scalar multiplications

Two elliptic curve scalar multiplications (ECMLT) are used in some important elliptic curve encryption algorithms, a pseudo-pipelined VLSI architecture of two ECMLTs over GF(2m) is proposed for these algorithms. The proposed architecture includes three word-serial finite field (FF) multipliers, and each FF multiplier has word size w. Implemented using FPGA, two ECMLTs are computed in approximately 4⌈m/w⌉(m-1)clock cycles in the proposed architecture. Compared with the architectures proposed by other authors recently, it is shown that the computation time for two ECMLTs is the shortest by using our proposed architecture.
Comparaison de critères de pureté pour l'intégration de connaissances en clustering semi-supervisé

Résumé. L’utilisation de connaissances pour améliorer les processus de fouille de données a mobilisé un important effort de recherche ces dernières années. Il est cependant souvent difficile de formaliser ce type de connaissances, comme celles-ci sont souvent dépendantes du domaine. Dans cet article, nous nous intéressons à l’intégration de connaissances sous la forme d’objets étiquetés dans les algorithmes de clustering. Plusieurs critères permettant d’évaluer la pureté des clusters sont présentés et leur comportement est comparé sur des jeux de données artificiels. Les avantages et les inconvénients de chaque critère sont analysés pour aider l’utilisateur à faire un choix.
“ The Determinants of Patient Satisfaction in the United States ”

Hospitals and other healthcare facilities face a problem in determining how to efficiently allocate resources to achieve optimal patient satisfaction at a relatively reasonable cost. This paper examines national data to gain insight on which variables are significant determinants of patient satisfaction. Using 2014 hospital specific patient satisfaction data from the Centers for Medicare & Medicaid Services, 2014 gross hospital revenue data from the American Hospital Directory and additional state-level data, this study ultimately determines the characteristics of hospitals which patient’s take most into account when reflecting upon their experience within the hospital setting.
Interaction of two unequal corotating vortices

Previous high-resolution contour dynamics calculations [Dritschel and Waugh, Phys. Fluids A 4, 1737 (1992)] have shown that in two-dimensional inviscid flow the interaction of two unequal corotating vortices with uniform vorticity is not always associated with vortex growth and may lead to vortices smaller than the original vortices. In the present study, we investigate whether these results also hold for two-dimensional vortices with continuous vorticity distributions. Similar flow regimes are found as for uniform vorticity patches, but the variation of the flow regimes with the initial vortex radii and peak vorticities is more complicated and strongly dependent on the initial shape of the vorticity profile. It is found that the “halo” of low-value vorticity, which surrounds the cores of continuous vortices, significantly increases the critical distance at which the weaker vortex is destroyed. The halo also promotes the vortex cores to merge more efficiently, since it accounts for a substantial part of t.
Comparison of pharmacokinetics and pharmacodynamics of docetaxel and Cisplatin in elderly and non-elderly patients: why is toxicity increased in elderly patients?

PURPOSE Following phase I studies of docetaxel and cisplatin in patients with non-small-cell lung cancer, the recommended doses of docetaxel were different for elderly (> or = 75 years) and non-elderly (< 75 years) patients. To elucidate the mechanism of the difference, the pharmacokinetics of docetaxel and cisplatin were investigated in two phase II studies separately conducted in elderly and non-elderly patients. PATIENTS AND METHODS Twenty-seven elderly and 25 non-elderly patients were treated with three weekly administrations of docetaxel and cisplatin every 4 weeks. Doses of docetaxel were 20 and 35 mg/m(2) for elderly and non-elderly patients, respectively. All patients received 25 mg/m(2) of cisplatin. The pharmacokinetics and pharmacodynamics of docetaxel and cisplatin were compared in elderly and non-elderly patients. RESULTS There were no differences in pharmacokinetics of docetaxel or cisplatin between elderly versus non-elderly patients with regard to clearance and volume of distribution. In the pharmacodynamic analysis, neutropenia was positively correlated with the area under the concentration-time curve for docetaxel but not for cisplatin. In evaluating the relationship between neutropenia and the area under the concentration-time curve of docetaxel, elderly patients experienced greater neutropenia than those predicted by a pharmacodynamic model developed in non-elderly patients; the residual for prediction of the percent change in neutrophil count was -11.2% (95% CI, -21.8 to -0.5%). CONCLUSION The pharmacokinetics of docetaxel and unchanged cisplatin were not different between elderly and non-elderly patients. The elderly patients were more sensitive to docetaxel exposure than the non-elderly patients, resulting in the different recommended doses for the phase II studies.
The Genexpress IMAGE knowledge base of the human brain transcriptome: a prototype integrated resource for functional and computational genomics.

Expression profiles of 5058 human gene transcripts represented by an array of 7451 clones from the first IMAGE Consortium cDNA library from infant brain have been collected by semiquantitative hybridization of the array with complex probes derived by reverse transcription of mRNA from brain and five other human tissues. Twenty-one percent of the clones corresponded to transcripts that could be classified in general categories of low, moderate, or high abundance. These expression profiles were integrated with cDNA clone and sequence clustering and gene mapping information from an upgraded version of the Genexpress Index. For seven gene transcripts found to be transcribed preferentially or specifically in brain, the expression profiles were confirmed by Northern blot analyses of mRNA from eight adult and four fetal tissues, and 15 distinct regions of brain. In four instances, further documentation of the sites of expression was obtained by in situ hybridization of rat-brain tissue sections. A systematic effort was undertaken to further integrate available cytogenetic, genetic, physical, and genic map informations through radiation-hybrid mapping to provide a unique validated map location for each of these genes in relation to the disease map. The resulting Genexpress IMAGE Knowledge Base is illustrated by five examples presented in the printed article with additional data available on a dedicated Web site at the address http://idefix.upr420. vjf.cnrs. fr/EXPR++ +/ welcome.html.
P2Y1 Receptor-evoked Glutamate Exocytosis from Astrocytes

ATP, released by both neurons and glia, is an important mediator of brain intercellular communication. We find that selective activation of purinergic P2Y1 receptors (P2Y1R) in cultured astrocytes triggers glutamate release. By total internal fluorescence reflection imaging of fluorescence-labeled glutamatergic vesicles, we document that such release occurs by regulated exocytosis. The stimulus-secretion coupling mechanism involves Ca2+ release from internal stores and is controlled by additional transductive events mediated by tumor necrosis factor-α (TNFα) and prostaglandins (PG). P2Y1R activation induces release of both TNFα and PGE2 and blocking either one significantly reduces glutamate release. Accordingly, astrocytes from TNFα-deficient (TNF–/–) or TNF type 1 receptor-deficient (TNFR1–/–) mice display altered P2Y1R-dependent Ca2+ signaling and deficient glutamate release. In mixed hippocampal cultures, the P2Y1R-evoked process occurs in astrocytes but not in neurons or microglia. P2Y1R stimulation induces Ca2+-dependent glutamate release also from acute hippocampal slices. The process in situ displays characteristics resembling those in cultured astrocytes and is distinctly different from synaptic glutamate release evoked by high K+ stimulation as follows: (a) it is sensitive to cyclooxygenase inhibitors; (b) it is deficient in preparations from TNF–/– and TNFR1–/– mice; and (c) it is inhibited by the exocytosis blocker bafilomycin A1 with a different time course. No glutamate release is evoked by P2Y1R-dependent stimulation of hippocampal synaptosomes. Taken together, our data identify the coupling of purinergic P2Y1R to glutamate exocytosis and its peculiar TNFα- and PG-dependent control, and we strongly suggest that this cascade operates selectively in astrocytes. The identified pathway may play physiological roles in glial-glial and glial-neuronal communication.
Implications of nonrandom seed abscission and global stilling for migration of wind‐dispersed plant species

Migration of plant populations is a potential survival response to climate change that depends critically on seed dispersal. Biological and physical factors determine dispersal and migration of wind‐dispersed species. Recent field and wind tunnel studies demonstrate biological adaptations that bias seed release toward conditions of higher wind velocity, promoting longer dispersal distances and faster migration. However, another suite of international studies also recently highlighted a global decrease in near‐surface wind speeds, or ‘global stilling’. This study assessed the implications of both factors on potential plant population migration rates, using a mechanistic modeling framework. Nonrandom abscission was investigated using models of three seed release mechanisms: (i) a simple drag model; (ii) a seed deflection model; and (iii) a ‘wear and tear’ model. The models generated a single functional relationship between the frequency of seed release and statistics of the near‐surface wind environment, independent of the abscission mechanism. An Inertial‐Particle, Coupled Eulerian‐Lagrangian Closure model (IP‐CELC) was used to investigate abscission effects on seed dispersal kernels and plant population migration rates under contemporary and potential future wind conditions (based on reported global stilling trends). The results confirm that nonrandom seed abscission increased dispersal distances, particularly for light seeds. The increases were mitigated by two physical feedbacks: (i) although nonrandom abscission increased the initial acceleration of seeds from rest, the sensitivity of the seed dispersal to this initial condition declined as the wind speed increased; and (ii) while nonrandom abscission increased the mean dispersal length, it reduced the kurtosis of seasonal dispersal kernels, and thus the chance of long‐distance dispersal. Wind stilling greatly reduced the modeled migration rates under biased seed release conditions. Thus, species that require high wind velocities for seed abscission could experience threshold‐like reductions in dispersal and migration potential if near‐surface wind speeds continue to decline.
Immunoreactions involving platelet. VI. Reactions of maternal isoantibodies responsible for neonatal purpura. Differentiation of a second platelet antigen system.

Although there is some evidence that neonatal thrombocytopenic purpura, which occurs in otherwise normal children born of healthy mothers, is caused by maternal antibodies formed against fetal platelets (1-3), lack of reliable serologic techniques generally has prevented convincing demonstration of the responsible antibodies and has precluded thorough investigation of the properties and inheritance of specific platelet antigens presumed to be involved. Because experience in this laboratory has shown that complement fixation is the most sensitive technique for detecting several different types of antiplatelet antibodies (4-6), this technique was applied in a search for antibodies in the sera of normal mothers who had given birth to thrombocytopenic infants. In the present report the isoantibodies which were found are characterized, and the sensitivity of the complement fixation technique is compared with that of other techniques employed in attempts to detect antiplatelet antibodies.
Kth best algorithm for fuzzy bilevel programming

Organizational decision making often involves two decision levels. When the leader at the upper level attempts to optimize hislher objective, the follower at the lower level tries to find an optimized strategy according to each of possible decisions made by the leader. Furthermore, such bilevel decision making may involve uncertain parameters which appear either in the objective functions or constraints of the leader or the follower. Following our previous work, this study first proposes a fuzzy parameter bilevel programming model and related theories. It then develops an approximation Kth-Best algorithm for solving such fuzzy bilevel programming problems. A numerical example further illustrates the proposed algorithm.
An Approximation Scheme for Optimal Multicast Routing with Multiple QoS Constrains

This paper studies the problem of optimal multicast routing with multiple Quality-of-Service (QoS) constrains (OMRMC), which is regarded as a critical component in networks. However, it is not very efficient and effective for the existing algorithms. An undirected and connected graph G with m edges and n nodes is modeled to find a multicast routing tree from source to destination subset D in this paper, and a novel approximation algorithm called APP-OMRMC is proposed for OMRMC. The theoretical validations for the proposed method are presented to show its efficiency. After that, the different networks with different types of service are evaluated. Experimental results show that the proposed method APP-OMRMC is capable of finding the optimal (or minimum-cost) multicast routing tree with the approximation factor (1+ ε ) and time complexity of O(m τ K-1 ).
IST: Role of GIS in crime mapping and analysis

In most recent years crime analysis has become a broad-spectrum term that needs a lot of research on crime analysis and crime mapping. Crime mapping and spatial analysis accompaniments all of them and plays an integral role in the intrinsically new form of crime representation, visualization and to respond satisfactorily to the problem of criminality. This research blends statistical methods (cluster analysis) and spatial models created with GIS, established on police crime reports. This paper puts on the diverse utilities of GIS to recognize the hot spots of crime in addition to encourage the advancement of investigation inclination strategy for policing. The functional approach in the present investigation for crime mapping can be successfully applied for improvement of user-interfaces stage for the advancement of safe city strategies.
High performance deep neural network on low cost mobile GPU

In recent years, machine learning based on deep neural networks (DNN) is playing an increasingly important role. Artificial intelligence applications using DNN are achieving higher and higher accuracy levels. However, the multi-layer characteristic of a DNN makes for huge computational complexity consumption requirements. In order to feasibly run DNN applications on mobile devices, an efficient DNN flow optimized for a mobile GPU is desired. In this paper, a mobile-GPU-accelerated DNN flow is proposed. By the proposed input buffer address remapping scheme, shader assembly code optimization and kernel merging between computing nodes, 10.6 FPS is achieved in a 35.2 GFLOPS mobile GPU with 94.9mJ per frame, which is a 58x speed up and a 104x more energy efficient compared to a pure mobile CPU solution. Compared with state-of-the-art GPU accelerator devices and libraries, the proposed scheme provides a 226%~1000% higher computing efficiency.
Considerations of Protein Subpockets in Fragment‐Based Drug Design

While the fragment‐based drug design approach continues to gain importance, gaps in the tools and methods available in the identification and accurate utilization of protein subpockets have limited the scope. The importance of these features of small molecule–protein recognition is highlighted with several examples. A generalized solution for the identification of subpockets and corresponding chemical fragments remains elusive, but there are numerous advancements in methods that can be used in combination to address subpockets. Finally, additional examples of approaches that consider the relative importance of small‐molecule co‐dependence of protein conformations are highlighted to emphasize an increased significance of subpockets, especially at protein interfaces.
A Visual Approach to the Empirical Analysis of Social Influence

This paper starts from the observation that social networks follow a power-law degree distribution of nodes, with a few hub nodes and a long tail of peripheral nodes. While there exist consolidated approaches supporting the identification and characterization of hub nodes, research on the analysis of the multi-layered distribution of peripheral nodes is limited. In social media, hub nodes represent social influencers. However, the literature provides evidence of the multi-layered structure of influence networks, emphasizing the distinction between influencers and influence. The latter seems to spread following multi-hop paths across nodes in peripheral network layers. This paper proposes a visual approach to the graphical representation and exploration of peripheral layers and clusters to exploit underlying concept of k-shell decomposition analysis. The core concept of our approach is to partition the node set of a graph into hub and peripheral nodes. Then, a power-law based modified force-directed method is applied to clearly display local multi-layered neighbourhood clusters around hub nodes. Our approach is tested on a large sample of tweets from the tourism domain. Empirical results indicate that peripheral nodes have a greater probability of being retweeted and, thus, play a critical role in determining the influence of content. Our visualization technique helps us highlight peripheral nodes and, thus, seems an interesting tool to the visual analysis of social influence.
Patch Antennas partially filled with CRLH cells for Self-Diplexed Antennas for RFID Application

In this paper two dual-frequency (2.45 GHz and 1.72 GHz) self-diplexed two-port antennas based on patches partially filled with CRLH cells are proposed. The polarization at both ports can be either equal or orthogonal linear polarizations. The proposed radiator allows a multi-frequency performance keeping an easy manufacturing structure. The high isolation level is achieved thanks to a joint effect of the proposed feeding structure plus the addition of bandpass filters based on SSR coupled to the feeding lines. The isolation levels between each port are quite large for either polarization. This avoids the use of external filters or diplexers getting reduced-size self-diplexed antennas.