Miracle-dz/UniFAR-FTUs huggingface dataset:
An Assessment of the Impact of Wind Generation on System Frequency Control

Rising wind generation penetrations and the distinctive inertial characteristics of associated turbine technology will impact system frequency control. While wind production will displace conventional synchronous plant, empirical study data presented also suggest that the relationship between the total stored turbine kinetic energy and the total system power production for wind is a variable that exhibits significant nonlinearity. Changing trends in system frequency behavior of a power system following the loss of the largest generator are studied in detail here, using simplified frequency control models and extensive simulations of wind penetration scenarios over an extended multiyear timeframe. The system frequency response is characterized by the rate of change of frequency and the frequency nadir. Results show that increasing levels of doubly fed induction generators and high-voltage dc interconnection alter the frequency behavior significantly, and that system operators may have to be proactive in developing solutions to meet these challenges.
Book Reviews

In Hidden Champions: Lessons from 500 of the World’s Best Unknown Companies, Hermann Simon introduces us to 500 little-known, low-profile, but very successful, mostly family firms in Germany. Some of these firms make products with which most of us are familiar, such as Brita (85% world market share in point-of-use water filtration systems), Stihl (30% world market share in chain saws), and Tetra (50% world market share in tropical fish foods). Even with sometimes staggering world market shares, these firms remain largely uncelebrated. This is due sometimes to the nature of their products, such as those used in a manufacturing processes; subsumed in such end products as car sunroofs, perfume fragrances, and artificial hip joints; or simply too insignificant to notice, such as pencils, screws, or buttons. An equally important reason for low profiles is their desire for anonymity. These firms are explicit in their policies of not dealing with the press or even academic researchers. Simon uses three criteria in selecting his hidden champions: (1) Number one or two in the world market or number one in the European market in terms of market share; if market share is unknown, a company must be a leader relative to its strongest competitors. (2) Not more than $1 billion in sales revenue (4.4% of sample exceed this limit). (3) Low public visibility and awareness. The hidden champions are found in almost every industry and clearly dominate their markets. The mean world and relative market shares are 30.2% and 1.56%, respectively, the latter representing the ratio of the champion’s world market share to that of its nearest competitor. This indicates the average champion is 56% larger than its nearest competitor. Further, 76.5% of the sample are closely held, usually translated as family held, and only 2.4% are publicly held. The median age of the champion firm is 47 years, the oldest being founded in 1753; almost 8% are over 150 years old. Simon contrasts his champions to better known, more spectacular success stories such as Microsoft, Intel, Nintendo, etc. Typically, the hidden champions: • grow more slowly • compete in more stable markets and depend less on fashion and boom cycles • have to grow by crossing borders from the very outset, since their market in any one country is small
Diagnosis, localization, and management of pheochromocytoma pitfalls and follow‐up in 41 patients

Forty‐one patients who had pheochromocytoma are described. These patients represent the experience of the authors over the last 19 years. The diagnoses, investigations, treatments, and pitfalls of this study and the management of these patients are described. The most sensitive screening test was the urinary measurement of catecholamines, vanillylmandelic acid (VMA), and metanephrines. The most useful localizing procedure was the metaiodobenzylguanidine (MIBG) scintigraphy and computed tomography (CT). After careful alpha and beta adrenergic blockade in 32 patients, no complications occurred during or after tumor resection. When this procedure was ignored even in patients who had normal blood pressure before surgery, severe cardiovascular complications occurred and two patients died. In familial pheochromocytoma, bilateral adrenalectomy with preservation of normal adrenal cortical tissue when possible may be the method of choice, but careful follow‐up is warranted.
Development of Mobile EEF Learning System (MEEFLS) for Mobile Learning Implementation in Kolej Poly-Tech MARA (KPTM)

Authors : M. E. Marwan, A. R. Madar, N. Fuad Abstract : Mobile learning (m-learning) is a new method in teaching and learning process which combines technology of mobile device with learning materials. It can enhance student's engagement in learning activities and facilitate them to access the learning materials at anytime and anywhere. In Kolej Poly-Tech Mara (KPTM), this method is seen as an important effort in teaching practice and to improve student learning performance. The aim of this paper is to discuss the development of mlearning application called Mobile EEF Learning System (MEEFLS) to be implemented for Electric and Electronic Fundamentals course using Flash, XML (Extensible Markup Language) and J2ME (Java 2 micro edition). System Development Life Cycle (SDLC) was used as an application development approach. It has three modules in this application such as notes or course material, exercises and video. MEELFS development is seen as a tool or a pilot test for m-learning in KPTM.
A Service Discovery System based on Zookeeper with Priority Load Balance Strategy

The paper present a Dynamic Service Discovery System[1] with a Priority Load Balance Strategy. The system not only integrates Zookeeper[2] and tradition web project written with Spring and SpringMVC to achieve the dynamic service discovery function, which feeds the basic needs of the Priority Load Balance Strategy. The experimental test result shows that the new system has lots of advantages over the Traditional Service-Oriented Architecture and the load balance module gets a better performance.
Phospholipid biosynthesis and poliovirus genome replication, two coupled phenomena.

Poliovirus infection leads to an increase of phospholipid synthesis and the proliferation of new membranes, giving rise to a great number of cytoplasmic vesicles in the infected cells. Viral RNA replication is physically associated with these newly‐synthesized membranes. Cerulenin, an inhibitor of lipid biosynthesis, effectively blocks the growth of poliovirus in HeLa cells. The presence of cerulenin after virus entry prevents the synthesis of poliovirus proteins. However, if this antibiotic is added at later stages of the virus replication cycle, it has no effect on viral translation itself, nor on the proteolytic processing and myristoylation of poliovirus proteins. The synthesis of viral, but not cellular RNA is selectively inhibited by cerulenin. Analysis of the viral RNA made in poliovirus‐infected cells by specific minus‐or plus‐stranded RNA probes suggests a selective blockade by cerulenin of plus‐strand RNA synthesis. Finally, the synthesis of phospholipids and the proliferation of membranes does not take place if cerulenin is added to the culture medium. These findings indicate that continuous phospholipid synthesis is required for efficient poliovirus genome replication and provide new insights towards the understanding of the molecular events that occur during poliovirus growth.
Supercontinuum generation by self-phase modulation and induced phase modulation at fused silica thin plate array

Supercontinuum (SC) optical pulse generation using solid nonlinear media is demonstrated for a femtosecond laser pulse with relatively narrow initial spectrum width of ∼20 nm (50 fs, FWHM). We propose two methods for obtaining SC pulses with good beam quality. The first method is to increase the number of thin fused silica plates and optimize their position arrangement along the optical path using SPIDER measurements. The second method is to employ induced-phase modulation by the second-harmonic pulses in the thin plates. We obtain SC pulses ranging from 450 to 900 nm, which is comparable to pulses generated by a rare-gas filled hollow core fiber.
Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis

Objective To evaluate the effectiveness of replacing dietary saturated fat with omega 6 linoleic acid, for the secondary prevention of coronary heart disease and death. Design Evaluation of recovered data from the Sydney Diet Heart Study, a single blinded, parallel group, randomized controlled trial conducted in 1966-73; and an updated meta-analysis including these previously missing data. Setting Ambulatory, coronary care clinic in Sydney, Australia. Participants 458 men aged 30-59 years with a recent coronary event. Interventions Replacement of dietary saturated fats (from animal fats, common margarines, and shortenings) with omega 6 linoleic acid (from safflower oil and safflower oil polyunsaturated margarine). Controls received no specific dietary instruction or study foods. All non-dietary aspects were designed to be equivalent in both groups. Outcome measures All cause mortality (primary outcome), cardiovascular mortality, and mortality from coronary heart disease (secondary outcomes). We used an intention to treat, survival analysis approach to compare mortality outcomes by group. Results The intervention group (n=221) had higher rates of death than controls (n=237) (all cause 17.6% v 11.8%, hazard ratio 1.62 (95% confidence interval 1.00 to 2.64), P=0.05; cardiovascular disease 17.2% v 11.0%, 1.70 (1.03 to 2.80), P=0.04; coronary heart disease 16.3% v 10.1%, 1.74 (1.04 to 2.92), P=0.04). Inclusion of these recovered data in an updated meta-analysis of linoleic acid intervention trials showed non-significant trends toward increased risks of death from coronary heart disease (hazard ratio 1.33 (0.99 to 1.79); P=0.06) and cardiovascular disease (1.27 (0.98 to 1.65); P=0.07). Conclusions Advice to substitute polyunsaturated fats for saturated fats is a key component of worldwide dietary guidelines for coronary heart disease risk reduction. However, clinical benefits of the most abundant polyunsaturated fatty acid, omega 6 linoleic acid, have not been established. In this cohort, substituting dietary linoleic acid in place of saturated fats increased the rates of death from all causes, coronary heart disease, and cardiovascular disease. An updated meta-analysis of linoleic acid intervention trials showed no evidence of cardiovascular benefit. These findings could have important implications for worldwide dietary advice to substitute omega 6 linoleic acid, or polyunsaturated fats in general, for saturated fats. Trial registration Clinical trials NCT01621087.
Machine learning based rate adaptation in DASH to improve quality of experience

Video is becoming one of the biggest traffic generating elements and the current progressive download approach has been found inefficient in terms of resource utilization. A machine learning based approach is proposed for the video streaming with DASH (Dynamic adaptive streaming over HTTP) as an underlying architecture to help client adapt to the changing streaming environment. The reason for using machine learning for adaptation is to make client learn about the environment that too in unsupervised manner. This way the redundant work of adaptation for similar network signatures is eliminated, therefore running time complexity is reduced. The results of our work showed improved QoE and efficient bandwidth utilization, (upto 68.5%), compared with the already present DASH algorithms.
IDENTIFICATION OF G 2607 A MUTATION IN EGFR GENE WITH A SIGNIFICATIVE RATE IN MOROCCAN PATIENTS WITH NASOPHARYNGEAL CARCINOMA

The epidermal growth factor receptor (EGFR) is involved in the regulation of several cellular processes and in the development of many human cancers. Somatic mutations of EGFR at tyrosine kinase domain have been associated with clinical response to tyrosine kinase inhibitors (TKIs) in lung cancer patients. In this study, we evaluated the frequency of point mutations in EGFR for future use of TKI in clinical treatment of nasopharyngeal carcinoma (NPC). Sixty Moroccan patient specimens of NPC were analysed for EGFR mutations in the region delimiting exons 18 and 21 by direct sequencing. Our results showed the absence of mutations in the EGFR kinase domain in these exons in all 60 analysed specimens. Sequence analysis of the EGFR-TK domain, revealed the presence of (G2607A) polymorphism at exon 20. The genotypes AA and GA were found respectively in 39 (65%) and 16 (26.6%) cases. Statistical analysis showed no difference between the polymorphism and either gender or age of patients. Mutations in EGFR kinase domain are rare events in NPC biopsies, suggesting, that treatment of NPC patients with TKI may not be effective. However, EGFR G2607A polymorphism at exon 20 is frequent in NPC cases and could be associated to clinical response to TKI therapy.
Pentobarbitone inhibition of catecholamine secretion

1 The perfused isolated cow adrenal gland was used to investigate the effect of barbituric acid, phenobarbitone and pentobarbitone on catecholamine secretion. 2 Pentobarbitone reduced catecholamine secretion induced by a number of drugs which cause exocytosis. The concentration of pentobarbitone which caused a 50% inhibition of catecholamine secretion was for acetylcholine 5·6 × 10−5m, for carbachol 6·3 × 10−5m, for histamine 1·6 × 10−4m, for (+)‐amphetamine 4·4 × 10−5m and for potassium chloride 1·5 × 10−4m. The degree of inhibition by pentobarbitone was not dependent on the concentration of the secretagogue. 3 Pentobarbitone (up to 10−3m) did not inhibit the catecholamine release that was induced by acetyldehyde or by calcium chloride; it inhibited slightly (34%) the catecholamine secretion induced by tyramine. 4 Catecholamine release induced by carbachol was also inhibited by phenobarbitone (50% inhibition at 2·8 × 10−4m (n = 7)) but was unaffected by barbituric acid. 5 Pentobarbitone had no effect on spontaneous or on (+)‐amphetamine‐ or tyramine‐induced release of catecholamines from isolated chromaffin vesicles of cow adrenal medulla. 6 It is concluded that pentobarbitone inhibits catecholamine release by preventing a configurational change in the structure of the membrane of the chromaffin cell which is a necessary link between receptor activation and catecholamine release.
Novel methodology for assessment of prophylactic platelet transfusion therapy by measuring increased thrombus formation and thrombin generation

Currently, patients developing severe thrombocytopenia during chemotherapy treatment are prophylactically transfused with platelets. We developed two platelet function tests to report the improved haemostasis in the transfused patients, which were capable of detecting aberrant responsiveness of the platelets after transfusion. First, in a whole‐blood flow test, platelet adhesion and thrombus formation were determined under high‐shear flow conditions. Second, the procoagulant function of platelets was assayed in platelet‐rich plasma by measurement of thrombin generation. Experimental conditions were established, where flow‐induced adhesion and thrombin generation test parameters increased semi‐linearly with the platelet concentration, and informed on the activation properties of platelets. The transfusion effects were evaluated for 38 thrombocytopenic patients, who were transfused with platelets stored in plasma or in synthetic medium (platelet additive solution II). In most but not all patients, transfusion resulted in increased adhesion and thrombus formation, as well as in improved platelet‐dependent coagulation. Taken together, the increase in platelet count after transfusion explained 57% of the overall improvement in platelet function. In acute graft‐versus‐host disease, thrombus formation was normal, while platelet‐dependent coagulation was higher than expected. We conclude that assessment of flow‐induced adhesion and thrombin generation in acquired thrombocytopenia adequately determines the improved haemostatic activity by transfused platelets.
Identification of the Activating and Conjugating Enzymes of the NEDD8 Conjugation Pathway*

NEDD8 is a ubiquitin-like molecule that can be covalently conjugated to a limited number of cellular proteins, such as Cdc53/cullin. We have previously reported that the C terminus of NEDD8 is efficiently processed to expose Gly-76, which is required for conjugation to target proteins. A combination of data base searches and polymerase chain reaction cloning was used to identify a cDNA encoding human UBA3, which is 38% identical to the yeast homologue, 22% identical to human UBA2, and 19% identical to the C-terminal region of human UBE1. The human UBA3 gene is located on chromosome 3p13 and gave rise to a 2.2-kilobase pair transcript that was detected in all tissues. Human UBA3 could be precipitated with glutathione S-transferase (GST)-NEDD8, but not with GST-ubiquitin or GST-sentrin-1. Moreover, human UBA3 could form a β-mercaptoethanol-sensitive conjugate with NEDD8 in the presence of APP-BP1, a protein with sequence homology to the N-terminal half of ubiquitin-activating enzyme. We have also cloned human UBC12 and demonstrated that it could form a thiol ester linkage with NEDD8 in the presence of the activating enzyme complex. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway should allow for a more detailed study of the role of NEDD8 modification in health and disease.
Algorithmic trading, market efficiency and the momentum effect

The evidence put forward by Zhang (2010) indicates that algorithmic trading can potentially generate the momentum effect evident in empirical market research. In addition, upon analysis of the literature, it is apparent that algorithmic traders possess a comparative informational advantage relative to regular traders. Finally, the theoretical model proposed by Wang (1993), indicates that the informational differences between traders fundamentally influences the nature of asset prices, even generating serial return correlations. Thus, applied to the study, the theory holds that algorithmic trading would have a significant effect on security return dynamics, possibly even engendering the momentum effect. This paper tests such implications by proposing a theory to explain the momentum effect based on the hypothesis that algorithmic traders possess Innovative Information about a firm’s future performance. From this perspective, Innovative Information can be defined as the information derived from the ability to accumulate, differentiate, estimate, analyze and utilize colossal quantities of data by means of adept techniques, sophisticated platforms, capabilities and processing power. Accordingly, an algorithmic trader’s access to various complex computational techniques, infrastructure and processing power, together with the constraints to human information processing, allow them to make judgments that are superior to the judgments of other traders. This particular aspect of algorithmic trading remains, to the best of my knowledge, unexplored as an avenue or mechanism, through which algorithmic trading could possibly affect the momentum effect and thus market efficiency. Interestingly, by incorporating this information variable into a simplified representative agent model, we are able to produce return patterns consistent with the momentum effect in its entirety. The general thrust of our results, therefore, is that algorithmic trading can hypothetically generate the return anomaly known as the momentum effect. Our results give credence to the assumption that algorithmic trading is having a detrimental effect on stock market efficiency.
A methodological study of an intravenous fat tolerance test with Intralipid R emulsion.

The fat emulsion IntralipidR has been used as a tracer substance for plasma triglyceride in an intravenous fat tolerance test (IVFTT). A single intravenous injection of the emulsion was given; the turbidity of blood samples taken during the next 40 minutes was determined nephelometrically, and the elimination rate and various methodological aspects have been studied. Elimination followed first order kinetics so that a semilogarithmic plot gave a straight line for which the slope k2 could be calculated. Identical results were obtained whether venous plasma or capillary whole blood samples were used. The determination of turbidity due to the IntralipidR emulsion was not affected by the plasma concentration of ‘endogenous’ lipids. Storage of the plasma samples for two weeks before reading did not affect the k2 value. K2 was highly reproducible in the same individual from one day to another. It is suggested that the intravenous fat tolerance test described could be a convenient tool for the study of hyperlipi.
Sharing knowledge to achieve development goals

In 1996 the World Bank launched a comprehensive knowledge sharing initiative, based on the understanding that development knowledge is a global public good that belongs to everyone, and from which everyone should benefit. The main objectives were to develop a world-class knowledge management system and to improve and expand the sharing of development knowledge with clients and partners, as well as among Bank staff, in order to improve the quality of Bank operations and to enhance the capacity of client countries to achieve their development goals. But has the Bank met these objectives? To answer this question, this report discusses the Operations Evaluation Department's assessment of the knowledge initiative.
Determinants of foreign direct investment in tourism : the case of Malawi

Foreign Direct Investment, in spite of several challenges, is hailed as one of the vehicles for economic development, especially in developing countries. In the tourism industry, FDI brings much needed capital, technology, marketing skills and operations systems that would otherwise not be available in the host country. Both developed and developing countries are always competing to attract FOi to their countries. The primary goal of this study was therefore to investigate factors that investors consider when undertaking FOi into the tourist accommodation sector in Malawi. Malawi remains one of the few countries in Africa which has not attracted meaningful FOi into its tourist accommodation sector. The objective of the study is fourfold; to analyse foreign direct investment, to identify country and industry level factors that influence tourism FOi, to analyse Malawi's general investment climate and to make recommendations to government and industry on attracting FOi. The study conducted a literature study on general FOi and tourism-specific FOi and the Malawi investment climate. An empirical study was carried out, through a quantitative research method. The sample was derived using a probability sampling method and was extracted from a national tourist accommodation database. The research found that there is a strong relationship between the source country of tourist accommodation FOi in Malawi and tourist source countries. It also found that economic factors, perception and infrastructure, government policy, competitiveness and nature are important considerations when investing in the Malawi tourist accommodation sector, in that order. Industry level factors that respondents found important are protection of investment, availability of fresh water, labour disturbances I unrest and tourist receipts. Whilst the Malawi government uses investment incentives as a key to FOi attraction, researchers found that incentives are not ranked as important to prospective investors.