Miracle-dz/UniFAR-FTUs huggingface dataset:
Depression and 1-year prognosis in unstable angina.

BACKGROUND Depression is common after acute myocardial infarction and is associated with an increased risk of mortality for at least 18 months. The prevalence and prognostic impact of depression in patients with unstable angina, who account for a substantial portion of acute coronary syndrome admissions, have not been examined. METHODS Interviews were carried out in hospital with 430 patients with unstable angina who did not require coronary artery bypass surgery before hospital discharge. Depression was assessed using the 21-item self-report Beck Depression Inventory and was defined as a score of 10 or higher. The primary outcome was 1-year cardiac death or nonfatal myocardial infarction. RESULTS The Beck Depression Inventory identified depression in 41.4% of patients. Depressed patients were more likely to experience cardiac death or nonfatal myocardial infarction than other patients (odds ratio, 4.68; 95% confidence interval, 1.94-11.27; P<.001). The impact of depression remained after controlling for other significant prognostic factors, including baseline electrocardiographic evidence of ischemia, left ventricular ejection fraction, and the number of diseased coronary vessels (adjusted odds ratio, 6.73; 95% confidence interval, 2.43-18.64; P<.001). CONCLUSIONS Depression is common following an episode of unstable angina and is associated with an increased risk of major cardiac events during the following year.
Food Security, Poverty, and Human Development in the United States

Access to food is essential to optimal development and function in children and adults. Food security, food insecurity, and hunger have been defined and a U.S. Food Security Scale was developed and is administered annually by the Census Bureau in its Current Population Survey. The eight child‐referenced items now make up a Children's Food Security Scale. This review summarizes the data on household and children's food insecurity and its relationship with children's health and development and with mothers' depressive symptoms. It is demonstrable that food insecurity is a prevalent risk to the growth, health, cognitive, and behavioral potential of America's poor and near‐poor children. Infants and toddlers in particular are at risk from food insecurity even at the lowest levels of severity, and the data indicate an “invisible epidemic” of a serious condition. Food insecurity is readily measured and rapidly remediable through policy changes, which a country like the United States, unlike many others, is fully capable of implementing. The food and distribution resources exist; the only constraint is political will.
Biological responses of the marine diatom Chaetoceros socialis to changing environmental conditions: A laboratory experiment

Diatoms constitute a major group of phytoplankton, accounting for ~20% of the world’s primary production. It has been shown that iron (Fe) can be the limiting factor for phytoplankton growth, in particular, in the HNLC (High Nutrient Low Chlorophyll) regions. Iron plays thus an essential role in governing the marine primary productivity and the efficiency of biological carbon pump. Oceanic systems are undergoing continuous modifications at varying rates and magnitudes as a result of changing climate. The objective of our research is to evaluate how changing environmental conditions (dust deposition, ocean warming and acidification) can affect marine Fe biogeochemistry and diatom growth. Laboratory culture experiments using a marine diatom Chaetoceros socialis were conducted at two temperatures (13°C and 18°C) and under two pCO2 (carbon dioxide partial pressure) (400 μatm and 800 μatm) conditions. The present study clearly highlights the effect of ocean acidification on enhancing the release of Fe upon dust deposition. Our results also confirm that being a potential source of Fe, dust provides in addition a readily utilizable source of macronutrients such as dissolved phosphate (PO4) and silicate (DSi). However, elevated atmospheric CO2 concentrations may also have an adverse impact on diatom growth, causing a decrease in cell size and possible further changes in phytoplankton composition. Meanwhile, ocean warming may lead to the reduction of diatom production and cell size, inducing poleward shifts in the biogeographic distribution of diatoms. The changing climate has thus a significant implication for ocean phytoplankton growth, cell size and primary productivity, phytoplankton distribution and community composition, and carbon (C), nitrogen (N), phosphorus (P), silicon (Si) and Fe biogeochemical cycles in various ways.
Formation of Specific Efferent Connections in Organotypic Slice Cultures from Rat Visual Cortex Cocultured with Lateral Geniculate Nucleus and Superior Colliculus

Cells in the cerebral cortex project to many distant regions in the brain. Each cortical target receives input from a specific population of cells which have a characteristic morphology and which are located in a distinct cortical layer. In an attempt to learn about the mechanisms by which this stereotypic output pattern is generated during development, we have studied the formation of cortical projections in an in vitro system. Slices from developing rat visual cortex were cocultured with slices from the superior colliculus, the major target of cells in layer 5, and the lateral geniculate nucleus, the major target of cells in layer 6. Cortical neurons which established connections with tectal and thalamic explants were retrogradely labelled with fluorescent dyes. It was found that, in vitro, different populations of neurons project to these two targets, and that the laminar position and cellular morphology of the projecting cells were similar to their in vivo counterparts. These specific connections were established when the target explants were placed either next to the white matter or next to the pial side of cortical slice cultures. The axons of cells projecting to ectopic positioned explants reoriented their trajectories and grew through the cortical grey matter directly towards their targets. Thus subcortical targets exert an orienting effect specifically on their innervating cells and attract growing axons of the appropriate cells at a distance. These results suggest that different targets release different molecules that act selectively on specific populations of neurons. Therefore, chemotropic guidance is likely to play a significant role in the development of specific connections between cortical neurons and their target areas.
Neurobehavioral Functioning in Children with Fetal Alcohol Spectrum Disorder

Neurobehavioral functioning of 50 Canadian children diagnosed with Fetal Alcohol Spectrum Disorder (FASD) was evaluated. The aims of this study were to identify specific areas of weakness in neurobehavioral functioning, to examine whether neurobehavioral functioning was related to various predictor variables, and to determine which measures differentiated between children given a brain score of 2 (possible dysfunction) and 3 (probable dysfunction). Participants displayed difficulties with many aspects of intelligence, memory, executive functioning, and attention. Measures of Full scale and Verbal IQ, as well as memory for faces and numbers differentiated between children with a brain 2 and 3 ranking. An interesting pattern of strengths and weaknesses emerged as well as significant differences related to ethnic background, gender, and age. Aboriginal children and Caucasian children with FASD do not appear to show the same pattern of strengths and weaknesses in neurobehavioral functioning.
Ethanol-induced cephalic apoptosis requires phospholipase C-dependent intracellular calcium signaling.

BACKGROUND Although the ability of ethanol to elicit neural crest cell apoptosis is well documented, the initial target of ethanol in these cells, and the biochemical pathway leading to their apoptosis, have yet to be determined. Recent work in preimplantation mouse embryos demonstrates that ethanol induces a phospholipase-C (PLC)-dependent calcium transient that mediates ethanol's effects. We tested whether a similar effect on calcium and PLC is involved in ethanol-induced neural crest apoptosis. METHODS Chicken embryos were collected and loaded with Fluo-3-AM to assess the effects of ethanol on intracellular calcium levels. Pharmacological agents were used to determine the sources and mechanism of intracellular calcium increases. In separate experiments, embryos were treated in ovo with pharmacological modulators of calcium signaling prior to ethanol exposure, and resulting levels of cell death were assessed by using the vital dye acridine orange. RESULTS Ethanol exposure caused a localized increase in intracellular calcium levels in embryonic neural folds within 15 sec of ethanol exposure. Ethanol-induced apoptosis was specifically blocked by chelation of intracellular calcium before ethanol exposure. Pretreatment with the PLC inhibitor U73122 blocked ethanol-induced apoptosis as well as the intracellular calcium transient. Depletion of extracellular calcium resulted in a partial block of ethanol-induced apoptosis. CONCLUSIONS Ethanol exposure alters calcium signaling within the neurulation-stage chicken embryo in a PLC-dependent manner. Increases in intracellular calcium and PLC activity are necessary for ethanol's induction of apoptosis within cephalic populations. These effects likely represent an early and crucial event in the pathway leading to ethanol-induced cell death.
Computed Tomography Perfusion Using First Pass Methods for Lung Nodule Characterization

Objective:To evaluate computed tomography (CT) perfusion using first pass methods for lung nodule characterization. Methods:Fifty-seven patients with 51 malignant and 6 benign nodules underwent first-pass, dynamic contrast-enhanced-CT (50 mL, 3–5 mL/s.). Kinetic analysis tools were CT Perfusion 3 (GEMS, Milwaukee, WI), a distributed parameter model approach, yielding blood volume (BV; mL/100 g), blood flow (BF; mL/min/100 g), mean transit time (1/s), and permeability surface area (mL/min/100 g), and an in-house Patlak-style analysis yielding fractional BV (mL/100 g) and an estimate of extraction (Kps, mL/100 g/min). Results:CT Perfusion 3 parameters in malignant and benign nodules were: mean transit time 10.1 ± 0.9 1/s versus 11.1 ± 3.1 1/s (ns), permeability surface 23.3 ± 9.1 mL/min/100 g versus 19.6 ± 10.3 mL/min/100 g (ns), BF 111.3 ± 8.7 mL/min/100 g versus 39.1± 5.7 mL/min/100 g (P < 0.001), BV 9.3± 0.7 mL/100 g versus 4.1 ± 1.1 mL/100 g (P < 0.002); Patlak parameters were: Kps 13.3 ± 1.2 mL/100 g/min versus 3.9 ± 0.8 mL/100 g/min (P < 0.001), BV 8.4 ± 0.8 mL/100 g versus 3.6 ± 1.3 mL/100 g (P < 0.01). The two kinetic methods show good agreement for BV estimation (Bland–Altman plot). The limits of agreement (bias ±2 standard deviation of bias) were 1.2 ± 5.3 mL/100 g. Conclusion:CT Perfusion using first pass modeling appears feasible for lung nodule characterization. Given the short acquisition duration used, weaknesses of the modeling methods are exposed. Nonetheless, microvascular characterization in terms of BF, BV, or Kps appears useful in distinguishing malignant from benign nodules.
Nasolacrimal Stents for the Treatment of Epiphora: Technical Problems and Long-Term Results

Purpose: To evaluate the long-term effectiveness of nasolacrimal stents for the treatment of obstructive epiphora, and the complications related to the procedure. Methods: This study is a non-randomized prospective clinical trial. Eighty-five patients underwent fluoroscopally-guided placement of polyurethane stent in 86 lacrimal systems for the treatment of severe idiopathic obstructive epiphora. The sites of obstruction were: sac-duct junction (n = 65), sac (n = 10), and nasolacrimal duct (n = 11). The procedure was performed in an outpatient basis under local anesthesia. Patients were followed for a mean of 24 months (1-84) with clinical examinations and/or dacryocystography. Clinical success was defined as symptoms resolution or improvement, and the patency of the lacrimal system to irrigation. Results: Stent placement was technically successful in 76 (88.4%) eyes. Technical failures (11.6%) were caused by inability to pass the guide-wire through the lacrimal system. Immediate complications occurred in 19 (22%) eyes, were mild and included: self-limited epistaxis (7), mild palpebral hematoma (7), moderate pain (3), lacrimal puncta bleeding (1), palpebral emphysema (1), and false passage (1). Of the 76 inserted stents, 33 (43.4%) became occluded, and 43 (56.6%) remained patent after a mean of 24 months. Mean duration of stent patency was 38 months. Clinical success was achieved in 40 (52.6%) of the successfully implanted stents. Conclusions: The procedure is well tolerated and can be performed on an outpatient basis. Patency decreases with follow-up, and, in the long-term, the success rate is inferior to that achieved by external dacryocystorhynostomy. However, it many be considered as a valid alternative to surgery in selected patients.
Brain Bioenergetics and Cognitive Ability

We obtained 31P magnetic resonance spectra from the brains in vivo of 101 males (range 6–72 years). In addition, cognitive test data were obtained from 42 boys (6–13 years) and from 26 adult males (22–56 years) of this test group. Significant correlations were observed in both adults and children between various inorganic phosphate (Pi)-containing 31P peak ratios [e.g. Pi/adenosine triphosphate (ATP)] and (predominantly verbal) cognitive tasks. No change in the Pi/ATP ratio was observed across the age range studied. Brain pH was shown to decrease significantly with age in a relationship best described by a decaying exponential. This indicated that brain pH does not stabilize at adult values until at least the late teens. We explored the possibility of a relationship between brain pH and neuronal density. In particular, we noted that our previous observation of a relationship between pH and IQ in children was not readily detected in the adult populations, whereas phosphorus metabolite ratios (in particular, those containing Pi) were found to correlate with (predominantly verbal) cognitive task performance in both adults and children. We assessed how these observations may be interpreted in the context of a metabolic vs. histological debate.
Comparison of feature selection and classification combinations for cancer classification using microarray data

High throughput gene expression data can be used to identify biomarker profiles for classification. The accuracy of microarray based sample classification depends on the algorithm employed for selecting the features (genes) used for classification, and the classification algorithm. We have evaluated the performance of over 2000 combinations of feature selection and classification algorithms in classifying cancer datasets. One of these combinations (SVM for ranking genes + SMO) shows excellent classification accuracy using a small number of genes across three cancer datasets tested. Notably, classification using 15 selected genes yields 96% accuracy for a dataset obtained on an independent microarray platform.
Output power characteristics of tunable erbium-doped fiber ring lasers

The output power characteristics of a widely tunable erbium-doped fiber ring laser (EDFRL) have been analyzed. The effects of emission wavelength, total intracavity loss, erbium ion clustering, output coupling ratio, and active fiber length are investigated. A comprehensive theoretical model based on a two-level laser model with consideration of pair-induced quenching is proposed. To achieve good performance in an EDFRL, especially for a widely tunable bandwidth of over 100 nm and high slope efficiency, numerical results, which are in good quantitative agreement with the experimental results, indicate that minimization of the intracavity loss as well as optimization of the active fiber length and the output coupling ratio are very important. It is found that the existence of erbium ion clusters in the active fiber can help an EDFRL to emit at a longer wavelength, and hence may be favorable for achieving L-band laser although the output power is reduced and the power flatness is degraded significantly. These findings are useful for the design and optimization of erbium-doped fiber lasers, especially for tunable fiber lasers operating in the longer band or L-band.
Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2‐polarizing conditions

Background Human thymic stromal lymphopoietin (TSLP) is expressed in the human asthmatic lung and activates dendritic cells (DCs) to strongly induce proallergic T‐helper type 2 (Th2) cell responses, suggesting that TSLP plays a critical role in the pathophysiology of human asthma. Th2 cells are predominantly involved in mild asthma, whereas a mixture of Th1 and Th2 cells with neutrophilic inflammation, probably induced by Th17, affects more severe asthmatic disease. Exacerbation of asthmatic inflammation is often triggered by airway‐targeting RNA viral infection; virus‐derived double‐stranded RNA, Toll‐like receptor (TLR)3 ligand, activates bronchial epithelial cells to produce pro‐inflammatory mediators, including TSLP.
Acute myeloid leukaemia in the elderly: a review

The majority of patients with acute myeloid leukaemia (AML) are elderly. Advancements in supportive care and regimen intensification have resulted in improvements in clinical outcomes for younger AML patients, but analogous improvements in older patients have not been realized. While outcomes are compromised by increased comorbidities and susceptibility to toxicity from therapy, it is now recognized that elderly AML represents a biologically distinct disease that is more aggressive and less responsive to therapy. Some patients tolerate and benefit from intensive remission‐induction approaches, while others are best managed with less aggressive strategies. The challenge is to differentiate these groups based on host‐related and biological features, in order to maximize the therapeutic benefit and minimize toxicity. As more is understood about the complicated pathogenesis and molecular basis of AML, there are more opportunities to develop and test targeted therapies. Elderly patients, with their narrow therapeutic window, are well positioned to derive a benefit from these novel agents, and therefore, despite a difficult past, there are reasons to be optimistic about the future of elderly AML.
Plague into the 21 st Century

As an ancient scourge, plague caused deadly epidemics in medieval Europe, and in the 20th century, it caused extensive mortality in India and Vietnam. Crossing into the 21st century, it has attracted particular attention as a potential bioweapon, for which a new vaccine needs to be developed. Human plague syndromes are mainly bubonic, septicemic, and pneumonic, all caused by the bacterium Yersinia pestis. Considerable strides have been made in understanding the causative organism’s virulence, although plague has persisted as a killer disease in Africa, Asia, and the Americas [1]. This update focuses on epidemiological trends, bacterial virulence, diagnosis, and treatment of plague.
Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells

Pathogenic yeast Cryptococcus neoformans causes devastating cryptococcal meningoencephalitis. Our previous studies demonstrated that C. neoformans hyaluronic acid was required for invasion into human brain microvascular endothelial cells (HBMEC), which constitute the blood–brain barrier. In this report, we demonstrate that C. neoformans hyaluronic acid interacts with CD44 on HBMEC. Our results suggest that HBMEC CD44 is a primary receptor during C. neoformans infection, based on the following observations. First, anti‐CD44 neutralizing antibody treatment was able to significantly reduce C. neoformans association with HBMEC. Second, C. neoformans association was considerably impaired using either CD44‐knock‐down HBMEC or C. neoformans hyaluronic acid‐deficient strains. Third, overexpression of CD44 in HBMEC increased their association activity towards C. neoformans. Fourth, confocal microscopic images showed that CD44 was enriched at and around the C. neoformans association sites. Fifth, upon C. neoformans and HBMEC engagement, a subpopulation of CD44 and actin translocated to the host membrane rafts. Our results highlight the interactions between C. neoformans hyaluronic acid and host CD44 and the dynamic results of these interactions, which may represent events during the adhesion and entry of C. neoformans at HBMEC membrane rafts.
The Returns and Risk of Dynamic Investment Strategies: A Simulation Comparison

Historical stock market returns and risk can be quite different from historical stock investors’ returns and risk because of different timing and magnitude of investment flows. As Dichev (2007) points out, investors’ returns equal stock market returns only if the investors choose a buy-and-hold (BH) strategy; other strategies involve different timing and magnitude of investment flows, which create differences. With BH, investors do nothing no matter how stock prices change during the period of investment. With a contrarian or concave strategy, they buy more as prices fall and sell as they rise, whereas with a momentum or convex strategy, they sell as prices fall and buy as they rise. Contrarian and momentum strategies both make adjustments depending on price changes; therefore, both often make investment returns and risk unequal to the BH strategy. How, specifically, are the returns and risk different? As Perold and Sharpe (1988) demonstrate, while BH gives straight-line payoff diagrams, momentum and contrarian strategies create convex and concave payoff curves, respectively. These two strategies generally yield very different return distributions. Momentum and contrarian strategies can be seen as mirror images of one another on either side of the BH strategy. Therefore, it is interesting to know how these two dynamic strategies change returns and risk. Through Monte Carlo simulations, this paper compares the investment returns and risk of three strategies: (1) BH, (2) a contrarian strategy, constant-mix (CM), and (3) a momentum strategy, constant-proportion portfolio insurance (CPPI). The simulated results show that CM has the highest median returns followed by BH and then CPPI. In terms of value-at-risk, CPPI has the lowest risk, while CM has the