Miracle-dz/UniFAR-FTUs huggingface dataset:
Abstract A19: Identification of Heregulin (HRG) expression as a driver of a difficult-to-treat cancer phenotype and development of a companion diagnostic for the HRG-ErbB3 targeting drug seribantumab

Heregulin (HRG) is the cognate ligand of the ErbB3 receptor and has been identified as a potent driver of a distinct tumor cell phenotype characterized by enhanced survival that appears to be inherently more resistant to standard of care therapies. Seribantumab (MM-121) is a fully human monoclonal antibody designed to block HRG from binding to ErbB3 and to prevent the establishment of HRG-driven cancer cell survival in response to cytotoxic therapies. Clinical evidence from randomized studies suggests that patients who receive standard therapy have shorter progression-free survival (PFS) when their tumors are positive for HRG RNA expression compared to patients receiving standard therapy with HRG-negative tumors. The addition of seribantumab was able to enhance the anti-tumor effect of these respective standard therapies and prolong PFS in patients with HRG-positive tumors. Profiling data indicates that positive HRG expression can be found in more than a third of most solid tumors identifying a high unmet medical need. In order to identify HRG-driven tumors with a more difficult-to-treat phenotype, an RNA in situ hybridization (ISH) diagnostic assay has been developed. Details will be presented illustrating the benefits of RNA ISH over alternate detection methods for HRG. This includes the visualization of tumor cell HRG expression with high sensitivity and specificity in small tissue specimens such as fine needle aspirates and core needle biopsies. This assay is currently being used to select patients for inclusion into diagnostic-driven clinical studies. Citation Format: Sara Mathews, Gregory Finn, Arthur J. Kudla, Victoria Rimkunas, Peter Laivins, Gavin MacBeath, Akos Czibere, Jason Baum. Identification of Heregulin (HRG) expression as a driver of a difficult-to-treat cancer phenotype and development of a companion diagnostic for the HRG-ErbB3 targeting drug seribantumab. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr A19.
Facing Elderly Recipients in Combined Liver-Kidney Transplantation.

DOI: 10.1097/TP.0000000000003148 FACING ELDERLY RECIPIENTS IN COMBINED LIVER-KIDNEY TRANSPLANTATION Burcin Ekser, MD, PhD (1) Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Address correspondence to: Burcin Ekser, MD, PhD, Transplant Division, Department of Surgery, Indiana University School of Medicine, 550 University Blvd, Room 4601, Indianapolis, IN, 46202, Telephone: 317-948-3835; Fax 317-968-1254, Email: bekser@iupui.edu ORCID: 0000-0003-0741-8007 (Word counts: Abstract none; main text 980; References 10; Table 1)
Spannungsfelder in der stationären Betreuung alter Menschen

3 1 Einleitung . 6 1.1 Ausgangslage . 6 1.2 Forschungsstand . 7 Stationäre Alterseinrichtungen und Pflegepersonal . 7 Bewohner*innen und deren Angehörigen . 7 UBA . 8 2 Forschungsplan und Datengrundlage . 8 2.1 Qualitative Aktenanalyse . 8 2.2 Quantitative Aktenund Institutionsanalyse. 9 2.3 Validierungsworkshop . 9 3 Ergebnisse der qualitativen Aktenanalyse: Vier Beschwerdebereiche. 10 3.1 Veränderte Alltagsbedingungen . 11 3.2 Inadäquate Pflegehandlung . 13 3.3 Komplexe Betreuungssituation . 15 3.4 Konflikthafter Angehörigenkontakt . 17 4 Ergebnisse der quantitativen Aktenund Institutionsanalyse . 19 4.1 Quantitative Aktenanalyse: Beschwerdeakten und Institutionen . 19 Verteilung Beschwerdebereiche und Beschwerdemelder*innen . 19 Beschwerdebereiche und Beschwerdeakten pro Institution . 21 4.2 Quantitative Institutionsanalyse: SOMED-Kennzahlen . 21 Rechtsformen . 22 Mittelwertsund Medianvergleiche . 25 5 Zusammenfassung der Ergebnisse . 28 6 Schlussfolgerungen . 30 Literatur . 31 Anhang . 33 A Vergleiche Involvierte – Schweiz resp. Kanton ZH nach Rechtsform . 33 B Vergleich Beschwerdebereiche nach Rechtsform . 37 C Mittelwertund Medianvergleiche SOMED-Kennzahlen (ungewichtet) . 38 D Mittelwertund Medianvergleiche SOMED-Kennzahlen (gewichtet) . 42
La mesure de la qualité de vie : nouvel horizon dans l’évaluation des traitements des enfants présentant un syndrome de gilles de la tourette

Les enfants presentant le syndrome de Gilles de la Tourette (SGT) ont besoin de traitements efficaces et adaptes a leur realite clinique complexe. L’evaluation de l’effet des traitements ciblant la gestion des tics est principalement determinee par des mesures objectives. Or, ces mesures ne considerent pas la perception de l’enfant, contrairement a des instruments de mesure evaluant la qualite de vie qui permettent d’avoir un regard global sur la vie de l’enfant, en allant au-dela des symptomes qu’il presente. L’objectif de cette etude est d’identifier et d’analyser les instruments de mesure utilises dans la litterature scientifique pour evaluer la qualite de vie des enfants ayant le SGT. Des caracteristiques specifiques ont ete ciblees pour faire cette analyse, dont les proprietes psychometriques, le repondant, l’administration, l’adaptation sur le plan developpemental et la presence d’un modele conceptuel. Un total de huit instruments evaluant la qualite de vie ont ete cibles dans la presente revue de litterature, parmi ceux-ci, deux instruments de mesure font l’objet de recommandations. Cette etude facilitera le choix d’un clinicien ou d’un chercheur francophone qui desire employer un tel instrument, en lui permettant de tenir compte du point de vue de l’enfant ayant le SGT lors de l’evaluation de l’effet d’un traitement.
The Practice of Multiple Shari'ah Board Directorship and Fiduciary Duties

This chapter examines the legal paradigm of the application of multiple Shari’ah board directorship practice from the common law context of directorial fiduciary duties. It employs the critical legal studies approach to analyse the principles, legislations, case laws, policies, and guidelines in the United States, European Union, the United Kingdom, Ireland and Germany. This study scrutinises the polarity of views concerning the pragmatic Masyaqqah (necessity) surrounding the practice in discussion: the Masyaqqah that encourages and one that discourages the application of the practice and places these against the two predominant directorial fiduciary duties under the common law system namely, the duty to act bona fide and in the best interest of the company, and the duty to avoid conflict of interest. Whilst the practice has proven to benefit Islamic financial institutions (‘IFIs’), the findings also notice the substantial risks it could inflict on the IFIs’ business operations; some which could seriously damage their Shari’ah compliance assurance.
Tarifa para la línea amarilla de la empresa “Mi Teleférico”. Una aproximación a través de un Peak Load Pricing

La problematica del transporte urbano en la ciudad de La Paz, Bolivia, que incluye la complejidad de su topografia, el crecimiento del parque automotor y la desmesurada congestion vehicular que se presenta en las diferentes horas del dia, da lugar a la creacion de la empresa estatal “Mi Teleferico”, la cual se constituye en la primera empresa de transporte masivo por cable en la ciudad, conectando los diferentes vecindarios de la urbe y enlazando las ciudades de La Paz y El Alto. Este servicio de transporte se caracteriza por contar con una capacidad instalada que le permite cubrir las diferentes demandas que se presentan en una jornada, otorgando una solucion tecnologica compatible con las caracteristicas de la ciudad y los requerimientos de los consumidores.
Report of a Phase II Study of Proteasome Inhibitor Bortezomib (Velcade) in Patients with Relapsed or Refractory T-Cell Lymphoma.

The 26S proteasome plays a vital role in degrading regulatory proteins such as p53, p21, p27, NF-kB, I-kB, and bcl-2, that govern cell cycle, transcription factors activation, apoptosis and cell trafficking. Thus, the mechanisms by which bortezomib elicits its antitumor activity may vary among tumor types, and the extent to which each affected pathway is critical to the inhibition of tumor growth could also differ. The aim of this study was to determine the efficacy and toxicity of bortezomib in previously pretreated patients with peripheral T-cell lymphoma unspecified (PTCLU) and cutaneous T-cell lymphomas (CTCL). Each patient had to meet the following inclusion criteria to be enrolled in the study: histologically confirmed PTCLU or CTCL (according to REAL/WHO classification); any stage, any IPI, any bone marrow status; second or more relapse or refractory disease; age ≥ 18; ECOG performance status ≤ 2; Hb ≥ 10 g/dL, ANC ≥ 1.5x10 9 /L and platelets ≥ 100 x 10 9 /L; normal hepatic, renal and cardiac functions; and voluntary written informed consent. Bortezomib was given at 1.3 mg/m 2 IV push on days 1, 4, 8 and 11 every 21 days. Restaging was done every 2 cycles. Patients were treated for up to a total of 6 cycles unless removed from study for failure to respond or toxicity. The response criteria were those recommended by NCI sponsored Working Group. A total of 30 patients will be enrolled; so far 10 patients entered and preliminary results of this trial will be presented.
Real-Time State-of-Charge Tracking Embedded in the Advanced Driver Assistance System of Electric Vehicles

Range anxiety has remained a critical technological bottleneck in electric vehicles (EVs). The issue lies in the fact that the estimation of the EV's batteries state of charge (SoC) is still inaccurate and unreliable due to the complex and nonlinear characteristics of the batteries. To tackle the problem, this paper presents a novel real-time mixed SoC estimation algorithm for the EV's lithium-ion batteries for implementation in an advanced driver assistance system (ADAS). The mixed estimation algorithm combines: i) an improved Coulomb counting method (CCM) that takes into account the battery state-of-health, operating temperature, and aging effect, ii) a model-based method (MBM) that represents a real-time recursive structure of the battery, and iii) a bottom-up based method (BUBM) that takes into account a variety of the environmental conditions, traffic conditions, auxiliary loads, and driver's behavior. To validate the proposed algorithm, several laboratory tests under real-time driving cycles have been conducted on a Manganese-oxide Li-ion cell of a 2012 Nissan Leaf battery cell. Furthermore, the effectiveness of the model has been demonstrated by driving the Nissan Leaf along a selected route in Australia. The results demonstrate a great accuracy for the SoC estimation compared to previous models.
Degradation Modeling and Condition-Based Maintenance Decision-Making for Dy-namic System in S-plane

Degradation modeling and maintenance decision-making based on degradation information are two majors issues in the ﬁeld of reliability and maintenance research. This paper proposes an s-plane (complex plan) approach to deal with these two issues. A well-known mass-spring-damper dynamic system is considered as a case study. The loss of spring stiffness and of damper friction degrade the system performance over time. We show that the location of the system pole in the s-plane could be a good indicator to characterize the degradation of the whole system. Based on such an indicator, a maintenance policy is proposed to reduce as much as possible maintenance costs. We use the distance between the current and initial locations of the system pole to trigger maintenance on the system. Without any direct information on the components, we exploit the relative location of the system pole in the s-plane to decide which component (spring, damper or both) should be replaced. The performances of the proposed policy are pointed out via numerical comparisons with a more classical policy.
C4d Glomerular Deposits and Disease Progression in Native Idiopathic Membranous Nephropathy

Introduction: Since 1989 when Kusunoki et al. described C4d renal deposits in native idiopathic membranous nephropathy (nIMN) their role in disease progression has not been clarified yet. Recent studies have identified C4d glomerular staining as a marker of negative progression of renal function in a primary glomerular disease like IgA nephropathy. We have retrospectively analysed 15 consecutive formalin-fixed paraffin-embedded kidney biopsies from patients with nIMN (7F, 8M) performed in our Unit from October 1995 to February 2011. Methods: Kidney sections were stained using polyclonal rabbit IgG anti-human C4d antibodies. Normal renal tissue was obtained from heart-beating braindead donors before kidney harvesting. Positive control biopsy was a humoral kidney rejection with intense C4d staining. Data are expressed as M ± SD. Results: Ten (5F, 5M) of 15 nIMN kidney biopsies showed global and diffuse C4d glomerular capillary staining (C4d+). At 6-month follow-up (C4d+ 31 ± 26 months, C4d– 29 ± 31 months; P = NS) we observed a significantly higher 24-hour urinary protein excretion rate (UPr) in C4d+ (P = 0.0051 vs. C4d–), and a significantly lower MDRD eGFR (P = 0.0337 vs. C4d– at diagnosis) when compared with data at disease presentation. Conclusion: Our data suggest that C4d glomerular capillary deposits in nIMN with a follow-up longer than 6 months might be a negative prognostic factor for both UPr and eGFR. We are aware that our study has limitations like the relatively short term follow-up and the little number of biopsy analysed. Nevertheless, the association between increasing UPr, worsening of renal function and glomerular deposits of C4d in nIMN patients might deserve reporting and eventually confermation by further investigations.
Development of the Scintillating Fiber detector for timing measurements in the Mu3e experiment

The subject of this thesis is the development and characterization of one of the timing sub-systems in the Mu3e experiment - namely the Scintillating Fiber detector. Prototypes of staggered scintillating fibers with a diameter of 250 um are constructed in two distinct readout configurations within the scope of the present work. Silicon photomultipliers with different geometries are further explored for the optical readout of the fibers. The prototypes are then characterized in accelerated proton and electron beams, as well as with radioactive strontium sources. To evaluate their performance, the author developed dedicated data acquisition systems featuring established instruments for nuclear physics experiments and novel digitizing electronics. Following a comprehensive analysis, a time resolution better than 280 ps and an efficiency above 95 % are measured with the produced scintillating fiber ribbons. As a result, their feasibility for the Mu3e experiment is proven. The design of the fiber detector is refined based on the observed results and the experience gained in handling and producing these prototypes.
Morphological determinants of jumping performance in the Iberian green frog

Abstract Predation is one of the main selective forces in nature, frequently selecting potential prey for developing escape strategies. Escape ability is typically influenced by several morphological parameters, such as morphology of the locomotor appendices, muscular capacity, body mass, or fluctuating asymmetry, and may differ between sexes and age classes. In this study, we tested the relationship among these variables and jumping performance in 712 Iberian green frogs Pelophylax perezi from an urban population. The results suggest that the main determinant of jumping capacity was body size (explaining 48% of variance). Larger frogs jumped farther, but jumping performance reached an asymptote for the largest frogs. Once controlled by structural body size, the heaviest frogs jumped shorter distances, suggesting a trade-off between fat storage and jumping performance. Relative hind limb length also determined a small but significant percentage of variance (2.4%) in jumping performance—that is, the longer the hind limbs, the greater the jumping capacity. Juveniles had relatively shorter and less muscular hind limbs than adults (for a given body size), and their jumping performance was poorer. In our study population, the hind limbs of the frogs were very symmetrical, and we found no effect of fluctuating asymmetry on jumping performance. Therefore, our study provides evidence that jumping performance in frogs is not only affected by body size, but also by body mass and hind limb length, and differ between age classes.
SYSTEMIC AND FUNCTIONAL CHARACTERISTICS OF GERUND AS A POLYFUNCTIONAL UNIT OF THE ENGLISH LANGUAGE

The article deals with the speci c characteristics of gerundial forms as polyfunctional units used in online mass media texts. Both the linguistic aspect of gerundial forms, including semantic, syntactical and stylistic features, and a cognitive discursive aspect of polyfunctional units use in mass media are studied. The purpose of the study is a complex analysis for discovering systemic and functional characteristics of gerundial forms use in English mass media. The material chosen for the research process is based on the mass media discourse presented in the format of online media texts of the British social and political newspapers and magazines (The Guardian, The Times, The Independent, The Economist, The Week, The Telegraph). Following methods have been used as the methodological basis of the research due to its main purpose that deals with the linguistic and linguo-cognitive analysis of gerundial forms: sampling method, descriptive method, functional-stylistic analysis and contextual analysis. Academic novelty of the paper is that polyfunctional units are studied from the point of view of discourse analysis and relations between linguistic units and cognitive-discursive factors. As a result of the research it has been stated that functional features of gerundial forms contribute to discovering the systemic character of polyfunctionality. In conclusion, it should be mentioned that mental propositional structures are objectively associated with the conceptual content of the gerund as a polyfunctional unit. The dynamic character of the above propositional structures is able to provide polyfunctional units verbalization in the format of either nominative or verbal structures.
Piloting an Integrated, Interprofessional Programme for People Living With Type II Diabetes: Outcomes and Experiences

This paper reports quantitative and descriptive qualitative findings from a mixed-methods study exploring and evaluating the outcomes and experiences of clients, staff and students piloting an integrated interprofessional programme for community members with type II diabetes. The one-day per week, eight-week programme included interprofessional appointments, group education sessions and case conferences led by students from exercise and nutrition, health promotion, nursing, occupational therapy, oral health, physiotherapy, podiatry and counselling psychology. Participants shared their experiences in individual interviews or focus groups. Client outcomes were evaluated using basic clinical indicators and the Canadian Occupational Performance Measure (COPM) that assesses client goal satisfaction and performance. While only small expected changes to clinical indicators were noted, there were moderate increases in mean COPM scores for performance and satisfaction. Descriptive qualitative analysis identified enjoyment from working as a team, better client outcomes and new knowledge or learning as the most frequent experiences. Findings suggested increased self-management empowerment for clients and their support people, while students and staff experienced both learning from, appreciating and educating each other about their own and others’ roles, and better collaboration. The success of the pilot programme has led to its continuation; however, timing and resourcing challenges noted by participants could threaten sustainability and accommodation of more clients and students.
Testing Contextualized Word Embeddings to Improve NER in Spanish Clinical Case Narratives

In the Big Data era, there is an increasing need to fully exploit and analyze the huge quantity of information available about health. Natural Language Processing (NLP) technologies can contribute by extracting relevant information from unstructured data contained in Electronic Health Records (EHR) such as clinical notes, patients’ discharge summaries and radiology reports. The extracted information can help in health-related decision making processes. The Named Entity Recognition (NER) task, which detects important concepts in texts (e.g., diseases, symptoms, drugs, etc.), is crucial in the information extraction process yet has received little attention in languages other than English. In this work, we develop a deep learning-based NLP pipeline for biomedical entity extraction in Spanish clinical narratives. We explore the use of contextualized word embeddings, which incorporate context variation into word representations, to enhance named entity recognition in Spanish language clinical text, particularly of pharmacological substances, compounds, and proteins. Various combinations of word and sense embeddings were tested on the evaluation corpus of the PharmacoNER 2019 task, the Spanish Clinical Case Corpus (SPACCC). This data set consists of clinical case sections extracted from open access Spanish-language medical publications. Our study shows that our deep-learning-based system with domain-specific contextualized embeddings coupled with stacking of complementary embeddings yields superior performance over a system with integrated standard and general-domain word embeddings. With this system, we achieve performance competitive with the state-of-the-art.
Preoperative optimization of the chronic pain patient: enhanced recovery before surgery

This book is a combination of pain medicine and psychology. It targets optimising the chronic pain before surgery to prevent the development of chronic post-surgical pain and to prevent the flair of acute on chronic pain episodes. The book has 11 chapters. First chapter describes the scope of the problem, the economic burden and related complications. There is an overview of consequences of pain chronification and opioid use. Multiple papers are cited with detailed results on pre-op and post-op problems of opioids with effects on length of stay and success rates of surgery