Miracle-dz/UniFAR-FTUs huggingface dataset:
Abstract 4489: IL-10 blockade reactivates antitumor immunity in human colorectal cancer liver metastases

Background: Colorectal cancer (CRC) is the 4th most common cancer in the US, and the liver is the most common site of metastatic disease. Immune checkpoint inhibitor therapy has not been successful in achieving a clinical response in most patients with CRC liver metastases (CRCLM). The liver is known to induce tolerance to foreign antigens as a result of immunosuppressive cytokines including IL-10. We hypothesized that blockade of IL-10 signaling in CRCLM would potentiate tumor infiltrating lymphocyte (TIL)-mediated tumor cell death. Methods: We performed single-cell RNA sequencing (scRNAseq) of CRCLM using the 10x platform to evaluate for expression of IL-10 or IL-10 receptor (IL-10R) RNA within the tumor (n=8). To confirm if the IL-10R protein was present within the tumor microenvironment (TME), we also performed immunohistochemistry (IHC) (n=3). In order to study the functional effects of IL-10 blockade, we utilized a tumor slice culture (TSC) model, which allows for the study of cancers with their intact TME including immune cells. For TSCs, cores (6 mm diameter) were taken from freshly resected sterile human CRCLM and cut to 250 µm thick slices using a vibratome (n=3). Duplicate slices were treated with either IgG control or anti-IL-10 monoclonal antibodies and cultured for up to 6 days. To evaluate for histological evidence of necrosis and cell apoptosis within the tumor slice, we stained slides with either hematoxylin and eosin (HE 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4489.
Correlates of Body Composition and Nutritional Status of 9-12 Year Old School Going Children in Kochi

Assessment of body composition is important in the management of many illnesses as well as in the assessment of nutritional status. Human body composition varies widely from one population to another, as age related patterns of changes in body size and composition differ among populations. The study was conducted in 63 urban children of age 9-12 years from two schools in Ernakulam District, Kerala by purposive sampling method. Interview schedule was used for data collection. Anthropometric parameters of the subjects namely weight, height, body mass index, mid upper arm circumference, waist and hip circumference, waist hip ratio, sum of skin fold thickness were taken. Body composition was computed by two equations namely Mcardle et al and Deurenberg predictive equations. The collected data was analyzed by appropriate statistical analysis. On classifying the subjects according to BMI percentiles it was observed that 17.9 per cent of boys and 8.4 per cent of girls belong to the underweight, 10.3 per cent and 20.8 per cent of boys and girls were overweight respectively. The remaining had a normal BMI. The body fat per cent calculated using Deurenberg Predictive equation (1991) was 16.4 percent in boys and 20.4 percent in girls and by McArdle Predictive equations (1986) was 15.9 percent in boys and 16.8 percent in girls. On studying Pearson's correlation of anthropometric parameters with per cent body fat it was evident that there exists a positive correlation (P<.01) between all the anthropometric parameters and per cent body fat, indicating that there is an increase in the anthropometric dimensions of an individual. On studying, Pearson's correlation between SSFT and anthropometric parameters, it was evident that there exists a positive correlation (P<.01) between all the anthropometric parameters indicating increased subcutaneous fat. On studying the Pearson's correlation of nutrient intake with per cent body fat and fat mass, it was found that there was no significant correlation between these parameters. The findings provide a picture of the correlates of body composition and nutritional status of school going children aged 9-12 years.
Blood Stream Infections in Children with Malignancies: A Single Center Experience Risk Factors, Microbiological Isolates and Sensitivity Pattern

Aim: To determine risk factors, microbiological isolates and antibiotic sensitivity pattern of blood stream infections of pediatric malignancies. Study Design: A prospective single center cohort study included Children with malignancies that developed one or more episodes of septicemia during the period of their treatment and follow up. Place and Duration of Study: We included 46 children who were admitted to the Pediatric oncology Unit of Tanta University Hospitals, Egypt, over the period of six months. The included children had a microbiologically confirmed blood stream infections. Methodology: Positive blood cultures by BacT/ALERT were sub cultured on MacConkey agar, Original Research Article Amer et al.; MRJI, 18(3): 1-12, 2017; Article no.MRJI. 30595 2 blood agar, chocolate agar, and sabouraud agar. VITEK 2 Compact 15 was used for verification of bacterial identification and MIC determination. Results: Sixty seven blood stream infections were detected in 46 patients. Hematological malignancies (67.4%) and neutropenia (69.7%) were the major risk factors. Gram positive bacteria represented (53.7%) including mainly coagulase negative Staphylococci (38.9%) and Streptococci (30.6%). Methicillin resistance was detected in all S. aureus, 71.4% of Coagulase negative Staphylococci that were sensitive to ciprofloxacin (85.7%, 100%), gentamycin (85.7%, 100%) and clindamycin (71.4%) respectively. Gram negative bacteria represent (46.3%) mainly Klebsiella pneumoniae (38.7%). ESBL in Enterobacteriaceae was (81.3%) with sensitivity to ciprofloxacin, amikacin, piperacillin/ tazobactam and sulbactam/ cefoperazone (100%, 100%, 69.2%, 53.8%) respectively. Carbapenem resistance was detected in one isolate of K. pneumoniae, two P. aeruginosa and two A. baumanii. Intestinal translocation of Klebsiella pneumoniae in (41.7%, 5/12) and P. aeruginosa (40%, 2/5), as well as in the four detected cases of central line blood stream infections. Conclusion: The application of infection control guidelines and the strict antibiotic policy are mandatory for each institute. Selective digestive decontamination is considered to limit translocation. Carbapenem resistance was alarming and mandating more evaluation of β-lactam/βlactamase inhibitors in treatment of ESBL Enterobacteriaceae.
Relationship between Sunspot Numbers and Mean Annual Precipitation: Application of Cross-Wavelet Transform—A Case Study

Observations show that the Sun, which is the primary source of energy for the Earth’s climate system, is a variable star. In order to understand the influence of solar variability on the Earth’s climate, knowledge of solar variability and solar–terrestrial interactions is required. Knowledge of the Sun’s cyclic behavior can be used for future prediction purposes on Earth. In this study, the possible connection between sunspot numbers (SSN) as a proxy for the 11-year solar cycle and mean annual precipitation (MAP) in Iran were investigated, with the motivation of contributing to the controversial issue of the relationship between SSN and MAP. Nine locations throughout Iran were selected, representing different climatic conditions in the country. Cross-wavelet transform (XWT) analysis was employed to investigate the temporal relationship between cyclicities in SSN and MAP. Results indicated that a distinct 8–12-year correlation exists between the two time series of SSN and MAP, and peaks in precipitation mostly occur one to three years after the SSN maxima. The findings of this study can be beneficial for policymakers, to consider future potential droughts and wet years based on sunspot activities, so that water resources can be more properly managed.
Photo/thermo-responsive and size-switchable nanoparticles for chemo-photothermal therapy against orthotopic breast cancer

Tumor penetration of nanocarriers is still an unresolved challenge for effective drug delivery. Herein, we described a size-switchable nanoplatform in response to an external near-infrared (NIR) laser for transcellular drug delivery. The nanoplatform was constructed with a poly(N-isopropylacrylamide) (PNIPAM)-based nanogel encapsulating chitosan-coated single-walled carbon nanotubes, followed by loading a chemotherapeutic drug, doxorubicin (DOX). In mice bearing orthotopic breast tumors, the photothermal effect from single-walled carbon nanotubes upon NIR irradiation potently inhibited tumor growth. The antitumor effect of the nanomedicine with NIR irradiation might be attributed to its capability of transcellular transport and tumor penetration in mice. In addition, the nanomedicine with NIR irradiation could elicit an antitumor response by increasing cytotoxic T cells and decreasing myeloid-derived suppressor cells. These results validated the application of photo/thermo-responsive nanomedicine in the orthotopic model of breast cancer.
Fiscal Consolidations and Informality in Latin America and the Caribbean

The transmission mechanisms of fiscal policy are significantly affected by informality in the labour market. Extending a narrative database of fiscal consolidations in 14 countries from Latin America and the Caribbean between 1989 and 2016 in order to account for heterogeneity in terms of commitment to the reforms, I show that tax-based and spending-based multipliers are both recessionary and do not significantly differ one from another in this region. Furthermore, these multipliers decline in absolute value as the level of labour informality increases in the economy, although evidences are less robust for spending-based consolidations. An analysis of the effects of tax-based consolidations on private demand suggests that labour market informality constitutes a short-term social buffer that attenuates the contractionary effects of this type of policy by increasing investment opportunities through tax evasion and entrepreneurial alternatives to unemployment for dismissed workers.
Psychometric Properties of the Clinical Assessment of Prosocial Emotions: Version 1.1 (CAPE 1.1) in Young Males Who Were Incarcerated

The Clinical Assessment of Prosocial Emotions: Version 1.1 (CAPE 1.1) uses structured clinical judgments to diagnose the “with limited prosocial emotions” specifier for Conduct Disorder. This study examined (a) the internal consistency and interrater agreement, and (b) the convergent and divergent validity of the CAPE 1.1 in 72 young males who were incarcerated in two Spanish juvenile detention centers (age range = 14–22 years). The CAPE 1.1 showed good interrater agreement for making the diagnosis of the specifier and adequate internal consistency. The CAPE 1.1 was associated with other measures of callous–unemotional traits, but less consistently associated with other dimensions of psychopathy. Youth who met diagnostic criteria for the specifier scored higher on externalizing problems, but did not differ from other youth who were incarcerated on internalizing problems. These results provide preliminary support for the psychometric properties of the CAPE 1.1 for the clinical assessment of the specifier.
Why preen others? Predictors of allopreening in parrots and corvids and comparisons to grooming in great apes

Allogrooming in primates serves not only a hygienic function, but also plays a crucial role in maintaining strong affiliative bonds between group members, which in turn, underpin the emergence of cooperative behavior. In contrast, although allopreening occurs in many avian species, we know little about its social functions. Our study addresses this issue by investigating allopreening in a broad comparative data set including six corvid and nine parrot species. We assessed whether rates of allopreening initiations, proportion of time spent allopreening, and the number of grooming partners in captive group-housed birds were comparable to patterns observed in captive chimpanzees and bonobos. While parrots and corvids were found to have similar rates of social grooming to bonobos and chimpanzees, Pan species dedicated significantly more time to social grooming. Animals in larger groups had more grooming partners, but when controlling for the number of potential partners, birds tended to have fewer grooming interaction partners than Pan species. We then investigated whether allopreening in parrots and corvids was predicted by behavioral markers of affiliative social bonds (close physical proximity, active feeding, and low levels of agonistic behavior). Results revealed that providing allopreening to a partner was significantly predicted by often being in close proximity, but not engagement in active feeding or agonistic behavior. We examined the region allopreened in a subset of species and found that preening a partner's head was predicted by both close physical proximity and active feeding, while body allopreening was only predicted by close physical proximity. Head preening may confer more hygienic benefits to recipients, and thus, may be more selectively provided to valued partners. Results support the hypothesis that allopreening in corvids and parrots helps maintain social bonds with an individual's most important social partners, showing some similarities to allogrooming in primates.
Mathematical Model, Optimal Control and Transmission Dynamics of Avian Spirochaetosis

Avian Spirochaetosis is an acute endemic tick-borne disease of birds, caused by Borrelia anserins, a species of Borrelia bacteria. In this paper, we present a compartmental mathematical model of the disease for the bird population and Tick population. The disease steady-state and the conditions for reaching a stable disease-free steady state are determined. The analysis by Lyapunov method shows both local and global stability. Further investigation involves the introduction of controls to the model; the existence and uniqueness of optimal control are established. Finally, the effect of the controls is investigated using numerical solutions.
Costochodral graft with abdominal fat as Interpositinal graft versus costochodral graft alone for reconstruction of temporomandibular joint in bilateral ankylosis in adults: randomized controlled clinical trial

Aim: The aim of this study was to evaluate the improvement of function and reduction of recurrence rate in patients with bilateral temporomandibular joint ankylosis treated with costochondral graft and interpositional fat compared to costochondral graft alone. Materials and Methods: This was a randomized controlled trial conducted on 10 adult patients with bilateral TMJ ankylosis. In control group, TMJ reconstruction was performed with costochondral graft after gap arthroplasty. While in the intervention group, the same procedure was performed with the addition of autogenous abdominal fat graft as interposition material. All patients were followed up for at least 6 months. The primary outcome was the percentage of patients with reankylosis in each group. The secondary outcome was the change in maximal incisal opening (MIO) after 6 months. Results: Both groups showed no recurrence. Intervention group showed lower change in the MIO (1.8 ± 0.84 mm) compared to the control group (2.4 ± 0.89 mm). Conclusions: Interpositional abdominal fat with costochondral graft TMJ reconstruction for management of bilateral temporomandibular joint ankylosis was found to be beneficial with promising results regarding maintained gained range of mandibular function, with relapse avoidance. However with no evidence of recurrence in any of our cases and the non significant difference in MIO, its superiority over costochondral graft TMJ reconstruction has not been proved yet.
Understanding Customer Preferences Using Image Classification - A Case Study

Today, companies have a large amount of data at their disposal. In addition to classic data in text or table form, the number of images also increases enormously. This is particularly the case if the customer contact exists via the Internet, e.g., social networks, blogs or forums. If these images can be evaluated, they lead to a better understanding of the customer. Improved recommendations can be made and customer satisfaction can be increased. This paper shows by means of support vector machines (SVM), convolutional neural networks (CNN) and cluster analyses how it is possible for companies to evaluate image data on their own and thus to understand and classify the customer. The data of travel platform users serve as a case study. Advantages and disadvantages of, as well as prerequisites for SVMs and CNNs are pointed out and segmentation of the users on the basis of their images is made.
The results of perforated peptic ulcer surgery; a single center experience of 86 patients

Objective: At the present time, eradication of the helicobacter pylori infection is dramatically reduced the risk of the peptic ulcer disease. Whereas, complication rate of the peptic ulcer, such as perforations or bleedings have not reduced significantly yet. The aim of the current study is to analysis the surgical treatment outcomes of our experience in 86 patients with peptic ulcer perforation. Material and methods: Between January 2012 and December 2017, 86 patients who were operated emergently for perforated peptic ulcer disease with GrahamÂ’s omental patch procedure in our hospital were included in this study. Demographic, clinical data, diagnostic studies, surgical procedures, operative findings, postoperative complications and patient follow-up were analyzed. Results: The mean age was (41.57±16.09) years. Out of 86 cases there were 65 (75.6%) male patients and 21 (24.4%) female patients. The mean operation time was 66.98±18.61 minutes. The mean hospital stay period was 7.95±2.02. In three months follow- up period, endoscopy was done to all of these patients and peptic ulcer disease was not seen in any of them. Conclusion: Our findings revealed that GrahamÂ’s omental patch repair is still a useful method for perforated peptic ulcer disease. Low complication rates, low duration of hospital stay and also low postoperative morbidity can be achieved with good preoperative and postoperative supportive care in open surgery for peptic ulcer perforation. Laparoscopic surgery should be performed only in the presence of experienced surgeon and also in the presence of sufficient laparoscopic materials.
ConGaLSAR: A Constellation of Geostationary and Low Earth Orbit Synthetic Aperture Radar

Synthetic aperture radar (SAR), with its all-weather and day/night capabilities, plays an important role in Earth observation. Traditionally, SAR satellites fly in low Earth orbits, which can result in fast Doppler accumulation but long revisiting intervals. Although increasing the number of satellites extends the observation coverage significantly, a complex constellation leads to unacceptable cost. The geosynchronous SAR system realizes sustained observations for a specific area; however, the long integral time results in the obvious defocusing of objects, even in micro-motion. To achieve a fast response and a short revisiting time with high accuracy and low costs, a constellation of imaging radar satellites called Constellation of Geostationary and Low Earth Orbit SAR (ConGaLSAR) is proposed in this letter; ConGaLSAR employs a novel transponding mode (MirrorSAR) to economically achieve efficient revisiting and phase/time synchronizations. In this system, the ground echoes are amplified by the low-orbit satellites and then retransmitted back to the illuminating system for sampling and downlinking. In view of the specific geometry of the system, the sensitivity, resolutions, and effective observing area are discussed and precisely defined. Based on the theoretical analyses, a typical case of ConGaLSAR, consisting of one geostationary orbit illuminator and 24 low-orbit transponders, can achieve a 92.4-min revisiting interval and 3-m resolution for the Pacific Ocean.
Short-term (2 years) results of primary total hip replacement in 40 mobile elderly patients with fractured neck of femur

Background The option of primary total hip replacement in patients with fractured neck of femur gives satisfactory functional results, which evokes the idea of this research to study the outcome of total hip replacement (THR) in patients older than 60 years having fractured neck of femur. Patients and methods A total of 40 active patients older than 60 years were included in our series. Patients were operated after a mean of 5 weeks after fracture. All patients were operated on by THR, under regional anesthesia, using modified Hardinge approach in lateral position. Postoperatively, all patients were allowed to bear weight as tolerated on the second day after operation. All patients were followed up at 6 weeks, 3 months, 6 months, and every 6 months thereafter. Results The results were good in all patients at 3 months, excellent in 23 patients at 6 months, and excellent among all at 2-year follow-up, with mean harris hip score (HHS) of 94. Conclusion Primary THR is a good line of treatment in active patients older than 60 years with fractured neck of femur.
Initial Experience with Laparoscopic Mini-gastric Bypass in Korean Obese Patients

Purpose: To report our initial experience with laparoscopic mini-gastric bypass (LMGB) in Korean obese patients. Materials and Methods: From July 2016 to February 2018, 14 male patients underwent LMGB for morbid obesity at a single institution. Five trocars were placed in a U-shape formation and 1 trocar was placed at the epigastrium as a liver retractor; a window was created between the vagal nerve and lesser curvature at the gastric angle for entering the lesser sac; a narrow gastric tube (∼100-120 ml volume) was made; a linear-stapled gastrojejunostomy was created after bypassing the jejunum 200 cm from the Treitz’ ligament; and the Petersen defect was closed to prevent internal hernia. Patient demographics, operative time, estimated blood loss, postoperative hospital stay, complications, weight loss, and resolution of comorbidities were evaluated during 1 year of follow-up. Results: All procedures were successful by laparoscopy. The average age was 29 (19-49) years; weight, 164.9 (127-250) kg; and body mass index, 51.0 (42.4-81.6) kg/m. In 1 case, nephrectomy was simultaneously performed for early renal cell carcinoma. The mean operative time was 148.8 (120-175) min. The mean postoperative hospital stay was 1.9 (1-4) days. The percentage excess weight loss at 1, 3, 6, 9, and 12 months was 16.6%, 31.0%, 41.4%, 45.4%, and 50.4%, respectively. The resolution rate of type 2 diabetes mellitus, hypertension, and dyslipidemia was 75%, 40%, and 66.7%, respectively. There was no major complication including mortality during the follow-up. Conclusion: LMGB is a technically simple, safe, and effective procedure in Korean obese patients.
The influence of emotional dissonance, emotional intelligence and organizational commitment on job satisfaction of employees of Bank BUMN in Indonesia

This study aims to determine emotional dissonance, emotional intelligence as well as organizational commitment and their influences on job satisfaction of employees of Bank BUMN (state-owned banks) in Indonesia. The approach used in this research is a quantitative approach. The research population is 283 front office employees from 7 state-owned banks in Indonesia consisting of tellers, customer services staff, and marketing staff. All the 283 populations studied entirely. The methods of data analysis used multiple linear regression analysis. The results of test and analysis show that emotional dissonance has a negative and significant effect on job satisfaction of employees of Bank BUMN in Indonesia, emotional intelligence has a significant effect on employee job satisfaction and commitment have a positive and significant impact on job satisfaction of employees of Bank BUMN in Indonesia.