Miracle-dz/UniFAR-FTUs huggingface dataset:
Encoding and Verification of a Computer-Interpretable Guideline: A Case Study of Pressure-Ulcer Management

This study examined ways to improve the accuracy of translating clinical practice guidelines (CPGs) into a computer-interpretable guideline (CIG) for pressure-ulcer management using the Shareable Active Guideline Environment (SAGE) guideline model, and aimed to verify the accuracy of the obtained CIG. The study was conducted using the following procedures: selecting CPGs, extracting rules from the selected CPGs, developing a CIG using the SAGE guideline model, and verifying the obtained CIG with test cases using an execution engine. The CIG for pressure-ulcer management was developed based on 38 rules and three algorithms at the semiformal representation level using MS Excel and MS Visio. The CIG was encoded by two Activity Graphs consisting of 115 instances representing algorithms and rules as knowledge elements in the SAGE guideline model. Two errors were found and corrected. Results of the study demonstrated that a CIG representing knowledge on pressure-ulcer management can be effectively developed using commonly available programs and the SAGE guideline model, and that the obtained CIG can be verified with a locally developed execution engine. The CIG developed in the study could contribute to health information management once it is implemented successfully in a clinical decision support system.
Automatic Label Placement in Maps and Figures: Models, Algorithms and Experiments

A road map can be interpreted as a graph embedded in the plane, in which each vertex corresponds to a road junction and each edge to a particular road section. In this chapter, we consider the cartographic problem to place non-overlapping road labels along the edges so that as many road sections as possible are identi ed by their name, i.e., covered by a label. We show that this is NP-hard in general, but the problem can be solved in O(n3) time if the road map is an embedded tree with n vertices. In the subsequent chapter we then show how to make both the model and the algorithm practicable. This chapter is based on and partly taken from joint work with Andreas Gemsa and Martin Nöllenburg [GNN14, GNN15, NN16].
Abuse of Nutmeg (Myristica fragrans Houtt.): Studies on the Metabolism and the Toxicologic Detection of its Ingredients Elemicin, Myristicin, and Safrole in Rat and Human Urine Using Gas Chromatography/Mass Spectrometry

Seeds of nutmeg are used as spice, but they are also abused because of psychotropic effects described after ingestion of large doses. It was postulated that these effects could be attributable to metabolic formation of amphetamine derivatives from the main nutmeg ingredients elemicin (EL), myristicin (MY), and safrole (SA). In a case of a suspected nutmeg abuse, neither such amphetamine derivatives nor the main nutmeg ingredients could be detected in urine. The metabolites of EL, MY, and SA were identified using gas chromatography-mass spectrometry in rat urine and their presence in human urine of the nutmeg abuser was confirmed. The identified metabolites indicated that EL, MY, and SA were once and twice hydroxylated at the side chain. In addition, EL was O-demethylated at 2 positions followed by side chain hydroxylation. MY and SA were demethylenated and subsequently methylated. In the human urine sample, the following metabolites could be identified: O-demethyl elemicin, O-demethyl dihydroxy elemicin, demethylenyl myristicin, dihydroxy myristicin, and demethylenyl safrole. As in the human urine sample, neither amphetamine derivatives nor the main nutmeg ingredients could be detected in the rat urine samples. Finally, toxicologic detection of nutmeg abuse was possible by identification of the described metabolites of the EL, MY, and SA in urine applying the authors' systematic toxicologic analysis procedure using full-scan gas chromatography-mass spectrometry after acid hydrolysis, liquid-liquid extraction of analytes, and microwave-assisted acetylation of extracted analytes.
Design of a variable gain and phase amplifier using double resonance and current conveyor circuits

Some radiofrequency applications require control of magnitude and phase of narrowband signals, such as beamforming networks for antenna arrays. An amplifier capable of varying magnitude and phase of a signal through control signals can be called a variable gain and phase amplifier (VGPA). In this paper a VGPA circuit is proposed which utilizes two double resonance circuits, each one with a voltage variable capacitor to produce magnitude and phase variations. To avoid excessive reflections at the output port, and to establish high impedance in certain parts of the circuit, two current conveyor circuits connected as voltage follower are used. Analysis of each stage as well as design methodology is presented. A design example is carried out and graphics for the properties of gain and phase are obtained using simulation tools. Although control of these characteristics is not independent, the advantage is that it can be done by a single circuit.
Role of adhesion molecules in mobilization of hematopoietic cells.

OBJECTIVE To study the changes of adhesion molecules' expressions during the recombinant human granulocyte-colony-stimulating factor (rhG-CSF) mobilization in peripheral blood stem cell transplantation (PBSCT), and to confirm the influence of rhG-CSF on hematopoietic stem cells, which are proposed to guide mobilization in PBSCT. METHODS Mice were injected subcutaneously with diluted rhG-CSF or normal saline for 7 days. The blood Sca-1(+) stem cell count and bone marrow (BM) nucleated cell count were enumerated. The expressions of CD49d and CD44 and the adhesive ability of mononuclear cells to bone marrow matrix (fibronectin) were examined by flow cytometry and (51)Cr adhesive assay, respectively. RESULTS The mobilizing effect of rhG-CSF on mice was the same as on humans. The number of Sca-1(+) cells in peripheral blood reached the peak on the seventh day, the BM nucleated cell count was reduced, and the expressions of CD49d and the cells' adhesive ability in BM and PB declined. CONCLUSIONS rhG-CSF can reduce some cell adhesion molecules' expressions and the adhesive ability of hematopoietic stem cells to BM matrix, therefore mobilizing hematopoietic stem cells (HSC) from the BM to the peripheral blood.
Operation Optimization for Performance Improvement of PV/converter Systems

Photovoltaic/converter modular system with cascaded configuration is always preferred for achieving relatively high voltage output, individual module MPPT and decreasing mismatching losses. However, the limit of conversion ratio brings about the issue that not all modules can operate at their maximum power points (MPP) under serious mismatching conditions. This paper mainly discussed this problem and proposed and approach that evaluated whether a low irradiation module should be bypassed or not. Simulations of representative cases were investigated and the results showed that limit of conversion ratio together with the lowest irradiation module's current restrained the operation current of other modules, which caused great losses. Further researches also demonstrated that such phenomenon could be settled by bypassing the low irradiation module.
A Longitudinal Examination of the Associations between Fathers' and Children's Attributions and Negative Interactions

The present investigation examined the concurrent and longitudinal relations between attributions and negative behavioral interactions in the context of the father-child dyad. Participants were 177 fathers and their young adolescents recruited from nonmetropolitan counties in the southeast. Results indicated that for children, attributions about their father play a significant role in their negative behavioral interactions with their father both within and across time. Interestingly, father’s earlier negative behavioral interactions with their children predicted children’s subsequent attributions about their father in the longitudinal analyses. In addition, both attributions and behavioral interactions were highly stable across time for both fathers and children.
Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation*

The death domain kinase, receptor interacting protein (RIP), is one of the major components of the tumor necrosis factor receptor 1 (TNFR1) complex and plays an essential role in tumor necrosis factor (TNF)-mediated nuclear factor κB (NF-κB) activation. The activation of NF-κB protects cells against TNF-induced apoptosis. Heat-shock proteins (Hsps) are chaperone molecules that confer protein stability and help to restore protein native folding following heat shock and other stresses. The most abundant Hsp, Hsp90, is also involved in regulating the stability and function of a number of cell-signaling molecules. Here we report that RIP is a novel Hsp90-associated kinase and that disruption of Hsp90 function by its specific inhibitor, geldanamycin (GA), selectively causes RIP degradation and the subsequent inhibition of TNF-mediated IκB kinase and NF-κB activation. MG-132, a specific proteasome inhibitor, abrogated GA-induced degradation of RIP but failed to restore the activation of IκB kinase by TNF, perhaps because, in the presence of GA and MG-132, RIP accumulated in a detergent-insoluble subcellular fraction. Most importantly, the degradation of RIP sensitizes cells to TNF-induced apoptosis. These data indicate that Hsp90 plays an important role in TNF-mediated NF-κB activation by modulating the stability and solubility of RIP. Thus, inhibition of NF-κB activation by GA may be a critical component of the anti-tumor activity of this drug.
Crawling for domain-specific hidden Web resources

The Hidden Web, the part of the Web that remains unavailable for standard crawlers, has become an important research topic during recent years. Its size is estimated to 400 to 500 times larger than that of the publicly indexable Web (PIW). Furthermore, the information on the hidden Web is assumed to be more structured, because it is usually stored in databases. In this paper, we describe a crawler which starting from the PIW finds entry points into the hidden Web. The crawler is domain-specific and is initialized with pre-classified documents and relevant keywords. We describe our approach to the automatic identification of Hidden Web resources among encountered HTML forms. We conduct a series of experiments using the top-level categories in the Google directory and report our analysis of the discovered Hidden Web resources.
Methods of oestrus prevention in dogs and cats: a survey of Turkish veterinarians’ practices and beliefs Métodos de prevención de estro en perros y gatos: una encuesta sobre las prácticas y creencias de médicos veterinarios de Turquía

Trescientos dos practicantes privados trabajando en Estambul, Ankara y Bursa y 35 miembros de Facultad pertenecientes a las Escuelas Veterinarias de Estambul, Ankara y Uluadg (Bursa) fueron encuestados mediante una entrevista personal, con el objeto de investigar las actitudes de los Médicos Veterinarios de Turquía hacia los métodos usados para la prevención de estro en perros y gatos, técnicas quirúrgicas para la esterilización, la edad a la cual los animales eran esterilizados y los materiales de sutura usados durante las cirugías. La mayoría de los veterinarios (60,2%) estaban a favor de la contracepción quirúrgica en perros y gatos y se determinó que la ovariohisterectomía era la técnica quirúrgica más común (97%). En perros, los veterinarios practicantes, comparado a especialistas, realizaron esterilización quirúrgica después del año de vida (P < 0,001). Sin embargo, en gatos, los especialistas prefirieron realizar la cirugía después del año de edad (9,8% vs. 25,9%) comparado a practicantes. Para la esterilización quirúrgica, la aproximación media ventral fue más común en perros (85%) mientras que en gatos la aproximación de flanco fue preferida (65%). El medicamento de primera opción para la contracepción fue el acetato medroxiprogesterona (68,8%) y 24% de los veterinarios consideró usar medicamentos sin licencia veterinaria para la prevención de estro en perros y gatos.
MODELLING TRUNCATED AND CLUSTERED COUNT DATA

Count response data often exhibit departures from the assumptions of standard Poisson generalized linear models. In particular, cluster level correlation of the data and truncation at zero are two common characteristics of such data. This paper describes a random components truncated Poisson model that can be applied to clustered and zero‐truncated count data. Residual maximum likelihood method estimators for the parameters of this model are developed and their use is illustrated using a dataset of non‐zero counts of sheets with edge‐strain defects in iron sheets produced by the Mobarekeh Steel Complex, Iran. The paper also reports on a small‐scale simulation study that supports the estimation procedure.
Prognostic Factors in Anterior Temporal Lobe Resections for Mesial Temporal Lobe Epilepsy: Multivariate Analysis

Summary: Purpose: Even though there have been several studies on the prognostic factors of temporal lobe epilepsy (TLE) after lobectomy, no studies have been performed for homogeneous mesial TLE. Furthermore, most studies on the predictors of outcome of epileptic surgery were based on univariate analyses and did not consider modern epileptic surgery investigation modalities such as brain magnetic resonance imaging (MRI) and positron emission tomography (PET). We attempted to identify the prognostic factors in anterior temporal lobectomy (ATL) for mesial TLE with multivariate analysis.
A framework using job sequencing algorithm for efficient dynamic resource management in cloud

The growth of Cloud Computing experienced in exponential in the last decade. Any application or system that are used in the past and which are going to be developed in future must be based on Cloud undoubtedly. Since cloud become inevitable in the present scenario the aspects of cloud are complex to define and hard to accomplish. As the Cloud enhanced in enormous size, the billing of usage of Clouds which is high in demand becomes the major threat to the world. Though there are more challenges in Cloud Computing, Dynamic Resource Management with low-cost is core problem to provide service to the end users in an efficient manner at various kinds of service levels. In this paper we propose simple design that makes it easier to provision the resource dynamically in the cloud environment as well as billing at lower cost. Staging of the design enables the cloud environment to provision all types of resources efficiently.
In Vitro Susceptibility of Isolates of Francisella tularensis Types A and B from North America

ABSTRACT Due to concern that Francisella tularensis, the causative agent of tularemia, may be used as a bioterrorist weapon, the Clinical and Laboratory Standards Institute recently provided a susceptibility testing method with breakpoints. Here, 169 isolates (92 type A and 77 type B) from North America were tested against seven antimicrobial agents (streptomycin, gentamicin, tetracycline, doxycycline, ciprofloxacin, levofloxacin, and chloramphenicol) used for the treatment of tularemia. The MICs for all of the isolates fell within the susceptible range. In addition, all isolates had MICs for erythromycin of 0.5 to 4 μg/ml, in contrast to an MIC of >256 μg/ml for the common laboratory strain LVS (live vaccine strain).
Prenatal Diagnosis in Combined Antithrombin and Factor V Gene Mutation

We report prenatal diagnosis in a family with combined antithrombin deficiency (type II heparin binding site) and factor V 506 Arg to Gln mutation. Both clinically unaffected parents are heterozygous for the antithrombin mutation, which results in a 99 Leu to Phe substitution, and the father is also heterozygous for the factor V gene defect. There is one daughter, homozygous for the antithrombin and heterozygous for the factor V mutations, who suffered a right‐sided hemiparesis at the age of 4 months due to occlusion of the left middle cerebral artery and a large left sided infarct followed by further thromboembolic events. The family requested prenatal diagnosis and chorionic villi was sampled at 12 weeks gestation. The fetus was shown to be heterozygous for the antithrombin and factor V gene mutations, the same genotype as the unaffected father. No further intervention was considered necessary. To our knowledge this is the first report of prenatal diagnosis in antithrombin deficiency.
Route for Bulk Millimeter Wave and Terahertz Metamaterial Design

A possible route for the design of 3-D metamaterials in the millimeter and terahertz (THz) frequency range is proposed in this paper. It consists of stacks of spatial filtering screens made of resonant subwavelength metallic elements deposited on polypropylene (PP) film substrates by a contact photolithography technique. A thorough characterization of PP films as a substrate in THz and its extension to millimeter waves is carried out. Then, a description of the fabrication process, followed by a thorough analysis of the yield of this process as well as the material properties, is reported. As a direct application, several filtering screens are studied, including the performance of multilayer configurations. It is shown that the losses do not increase significantly in the multilayer case, enabling both the fabrication and use of PP at these frequency ranges. Additionally, slow wave has been measured in a multilayer prototype. Full-wave electromagnetic simulations have been compared with measurement from several configurations, showing reasonably good agreement. These results open the possibility of implementing low-loss metamaterials in the millimeter and THz spectrum.
Genes Implicated in the Specification of the Eye in Drosophila or Vertebrates and Their Homologs

Although the eyes of all organisms have a common function, visual perception, their structures and developmental mechanisms are quite diverse. Recent research on eye development in Drosophila has identified a set of putative transcription factors required for the earliest step of eye development, specification of the field of cells that will give rise to the eye. These factors appear to act in a hierarchy, although cross-regulation may amplify the eye fate decision or promote progression to the next step. Surprisingly, homologous proteins are also involved in vertebrate eye development, suggesting that this regulatory network was present in a primitive common ancestor and that it has been adapted to control visual organ formation in multiple species. The identification of genes acting upstream and downstream of these transcription factors will contribute to our understanding of the establishment of a developmental field, as well as of the divergence of regulatory pathways controlling the formation of eye structures. BioEssays 21: 843–850, 1999. r 1999 John Wiley & Sons, Inc.
Les motivations des prises de contrôle : le cas des acquisitions par offre publique en France

Cette these propose une etude empirique sur le pourquoi des offres publiques d'achat et d'echange (OPA|E) en France sur la periode 1985-2002. Elle est structuree en trois parties : la description de notre problematique construite autour de la notion de creation de valeur et sur les divers cadres theoriques qui ont ete mobilises pour expliquer les FA le test d'un certain nombre de motivations theoriques des prises de controle en identifiant conjointement les caracteristiques des entreprises cibles et initiatrices d'OPA|E ; l'examen de la motivation disciplinaire en analysant la performance des entreprises cibles sur une longue periode avant l'OPA|E. Les resultats montrent que les motivations des OPA|E varient selon la periode analysee et different d'une vague a l'autre. L'hypothese disciplinaire n'apparait pas comme une motivation predominante dans les OPA|E realisees en France et, c'est plutot des considerations d'agence qui expliquent ces operations.
Metabolic and blood catecholamine responses to exercise during alkalosis.

The effects of metabolic alkalosis on muscle lactate accumulation and plasma catecholamine concentrations were studied in six highly trained subjects during short-term ergocycle exercises to exhaustion (375 W). The studies were performed after oral administration of NaHCO3 (alkalosis) and CaCO3 (placebo). There was a significant increase in resting blood pH after NaHCO3 ingestion (7.35 +/- 0.02) compared to placebo (7.27 +/- 0.02). A longer endurance time was achieved during alkalosis (75.3 +/- 8 s) than during control (61.5 +/- 2 s), but similar blood pH and HCO3- levels were found at exhaustion in both treatments. Metabolic alkalosis resulted in higher elevation in muscle lactate concentration (31.7 +/- 4.6 mmol.kg-1 wet weight) compared to control (17 +/- 4 mmol.kg-1 wet weight). Despite longer exercise duration in alkalosis, plasma norepinephrine and epinephrine concentrations at exhaustion were reduced by 30 and 34%, respectively. These results indicate that alkalosis increased muscle lactate accumulation during exhaustive exercise. These changes were associated with a reduced blood catecholamine response to exercise.
Fundamental study on multi-baseline SAR tomography by Pi-SAR-L2

The L-band fully polarimetric airborne SAR, called Pi-SAR-L2 has been operated by JAXA, Japan since 2012. Many datasets have collected. There are a few dataset collected by the repeat-pass observations among them. In this report, we apply the SAR tomography analysis to the repeat-pass multi-baseline dataset and verify the possibility of the SAR tomography by the Pi-SAR-L2.
Postoperative continuous wound infusion of ropivacaine has comparable analgesic effects and fewer complications as compared to traditional patient-controlled analgesia with sufentanil in patients undergoing non-cardiac thoracotomy.

OBJECTIVE To compare the postoperative analgesic effects of continuous wound infusion of ropivacaine with traditional patient-controlled analgesia (PCA) with sufentanil after non-cardiac thoracotomy. METHODS One hundred and twenty adult patients undergoing open thoracotomy were recruited into this assessor-blinded, randomized study. Patients were randomly assigned to receive analgesia through a wound catheter placed below the fascia and connected to a 2 ml/h ropivacaine 0.5% (RWI group) or sufentanil PCA (SPCA group). Analgesia continued for 48 h. Visual analogue scores (VAS) at rest and movement, Ramsay scores and adverse effects were recorded at 2, 8, 12, 24, 36 and 48 h after surgery. Three months after discharge, patient's satisfaction, residual pain and surgical wound complications were assessed. RESULTS General characteristics of patients were comparable between two groups. There were no statistical differences in the VAS scores and postoperative pethidine consumption between two groups (P > 0.05). However, when compared with SPCA group, the incidences of drowsiness, dizziness and respiratory depression, ICU stay and hospital expenditure reduced significantly in RWI group (P < 0.05). Patients' satisfaction with pain management was also improved markedly in RWI group (P < 0.05). CONCLUSION Continuous wound infusion with ropivacaine is effective for postoperative analgesia and has comparable effects to traditional PCA with sufentanil. Furthermore, this therapy may also reduce the incidences of drowsiness, dizziness, respiratory depression and decrease the ICU stay and hospital expenditure.