Miracle-dz/UniFAR-FTUs huggingface dataset:
A selective oleic acid albumin agar medium for tubercle bacilli.

Summary A selective medium for Mycobacterium tuberculosis and Myco. bovis has been developed containing polymyxin B 200 units per ml, carbenicillin 100 γ per ml, amphotericin B 10 γ per ml and trimethoprim 10 or 20 γ per ml in 7H10 oleic acid albumin agar. When the centrifuged deposit from sputum, liquefied by treatment with dithiothreitol, was plated directly on to the selective medium, less than 1 per cent. of plates were contaminated and the viable counts were about 240 per cent. higher than parallel counts after treatment of the deposit with NaOH and plating on 7H10 medium without drugs. A comparison of results on medium with and without the selective drugs showed that the drugs slowed the early growth of Myco. tuberculosis in slide culture and reduced viable counts by, at most, 10 per cent. Improved anti-fungal cover could be obtained with no reduction in viable counts by increasing the concentration of amphotericin B to 50 γ per ml.
Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: A systematic review

Background:Recombinant activated factor VII (factor VIIa) is a prohemostatic agent that can be used for patients with complicated coagulation disorders. Recombinant factor VIIa is, however, increasingly used for several other indications, including patients with a preexistent normal coagulation system but who experience serious bleeding, for example, after major surgery or trauma. Data Source:We performed a systematic review of all published and unpublished clinical studies using MEDLINE (1966–2004) and all other sources available to assess the available evidence on the efficacy and safety of recombinant factor VIIa in patients with or without coagulation disorders. Study Selection:We found 483 articles related to the pharmacologic use of recombinant factor VIIa, including 28 clinical trials, 124 case series, and 176 case reports, which were all considered for this review. Data Synthesis:Recombinant factor VIIa is an effective and relatively potent prohemostatic agent in approximately 90% of patients with hemophilia and inhibiting antibodies and other types of complex coagulation disorders. The application of recombinant factor VIIa in other patients who experience severe bleeding is promising, and although sound evidence from controlled clinical trials is only scarcely available so far, forthcoming trials are likely to provide more substantiation for this use. Recombinant factor VIIa appears to be relatively safe with a 1–2% incidence of thrombotic complications based on published trials. Conclusions:More randomized controlled clinical trials are required to assess the efficacy and safety of recombinant factor VIIa for patients without a preexistent coagulation disorder and with severe bleeding. In the meantime, off-label use of recombinant factor VIIa may be considered in patients with life-threatening bleeding.
Quelques modèles et méthodes pour l'étude de la cognition

Dossier de travaux incluant un echantillon de 12 publications sur les themes suivants: - Perception des lettres - Modeles de codage de donnees - Modeles de codage d'images - Reseaux de neurones et apprentissage supervise - Methodes de calcul des parametres de modeles - Methodes de validation de modeles et bases de donnees comportementales
Expression of epidermal growth factor (EGF) and the EGF receptor in the porcine oviduct.

The production, secretion, and localization of epidermal growth factor (EGF) and the distribution of the EGF receptor (EGF-R) were examined in the isthmus (I) and ampulla (A) of the oviducts from cyclic (C) and early-pregnant (P) gilts. Sexually mature gilts (n = 20) were divided equally into two groups: C and P. P gilts were bred twice (at 0 and 24 h), and all gilts were killed 48 h after onset of estrus. After removal of reproductive tracts, oviducts were isolated, flushed, opened longitudinally, divided by anatomical region, cut into 1-3-mm3 pieces, and placed in Dulbecco's modified Eagle's Essential medium (DMEM: F-12 + ITS [insulin, 5 micrograms/ml; transferrin, 5 micrograms/ml; and selenious acid, 5 ng/ml] + antibiotic). Half the tissue and medium were immediately homogenized and centrifuged, and the supernatant was removed. The remaining tissue was cultured in the medium for 24 h at 37 degrees C and 5% CO2, then prepared similarly for analysis. EGF was measured in the supernatant by a heterologous RIA. Concentration of EGF was expressed as nanogram/milliliter of EGF per milligram of protein in wet tissue. EGF concentrations were present in both regions of the oviducts of C and P gilts. It was greater in I than in A tissues for both C (I = 16.21 ng/ml vs. A = 13.91 ng/ml; p < 0.05) and P gilts (I = 14.27 ng/ml vs. A = 12.53 ng/ml; p < 0.10). Higher concentrations of EGF were found in I tissue of C gilts than in P gilts (C = 16.21 ng/ml vs. P = 14.27 ng/ml; p < 0.05). The media assayed from cultured explants of I and A sections from C and P gilts gave results that were highly correlated with those of immediately prepared tissue sections. Localization of EGF in frozen oviductal tissue sections was demonstrated by immunohistochemistry. The primary site of EGF immunostaining occurred in the epithelial cells (with highest intensity at the apical border) of both C and P gilts. A and I tissue sections from C gilts showed localization of EGF immunostaining mainly in epithelial cells and lamina propria cells, while those from P gilts stained less intensely. The presence of EGF-R was shown by incubating tissue imprints and frozen sections with EGF-erythrosin isothiocyanate, which revealed that EGF-R were distributed mainly on the membranes of epithelial cells. The study indicates that EGF and EGF-R are present in oviductal epithelial cells in both C and P gilts, with the highest concentration of EGF in C gilts. (ABSTRACT TRUNCATED AT 250 WORDS)
Extraskeletal myxoid chondrosarcoma of the cerebellopontine angle presenting during pregnancy

Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft-tissue sarcoma, which usually occurs in the lower extremities. It is often associated with chromosomal translocations. The clinical, radiological and pathological findings in extraskeletal myxoid chondrosarcoma, with an origin in the cerebellopontine angle, are described along with the issues associated with management of this tumour presenting acutely in a 26-year-old woman who was 20 weeks pregnant.
Predicting difficult intubation

Two pre‐operative tests for the prediction of difficult intubation are assessed. A modified Mallampati test and a measurement of thyromental distance were performed at the pre‐operative visit of 244 patients whose tracheas were subsequently intubated under general anaesthesia. Patients in whom the posterior pharyngeal wall could not be visualised below the soft palate, who also had a distance of less than 7 cm between the prominence of the thyroid cartilage and the bony point of the chin proved significantly more likely to present difficulty with intubation. The performance of these two simple tests on all patients before operation should allow the majority of cases of difficult intubation to be anticipated.
Preview Cues: Enhancing Access to Multimedia Content

We describe preview cues, a lightweight mechanism to assist exploration of multimedia content. A preview cue provides a preview of the kind of content/information associated with an area (as opposed to an instance) of a domain. Preview cues associate media files and their meta data with the label of a topic in a domain. A lightweight gesture such as brushing a cursor over a label initiates playback of the preview cue file associated with that label. With these cues, users can preview the type of content associated with an area of a domain in order to decide whether or not that area is of interest for further exploration before having to select it. In this paper we describe the preview cues mechanism. We look at one case study of an implementation of preview cues in the audio domain, and we present the results of a user study of preview cue deployment. We conclude with a discussion of issues for future research.
Kinetic Data on the Inhibition of High‐affinity Choline Transport into Rat Forebrain Synaptosomes by Choline‐like Compounds and Nitrogen Mustard Analogues

Abstract: A series of choline analogues and nitrogen mustard derivatives were evaluated as inhibitors of high‐affinity transport of choline in rat forebrain synaptosomes. When synaptosomes were preincubated for 10 min with choline mustard aziridinium ion, monoethylcholine and monoethylcholine mustard aziridinium ion, the agents appeared to be equipotent as inhibitors of high‐affinity uptake (Ki=2.63, 3.15 and 2.72 μm, respectively). Acetylcholine mustard aziridinium ion was less potent than these compounds (Ki= 27.8 μm), but it was more potent than ethoxycholine and ethoxycholine mustard aziridinium ion (Ki= 500 and 403 μm) as a blocker of choline transport. From study with these compounds it was concluded that the high‐affinity choline transport mechanism shows specificity for hydroxylated compounds over those in which the same hydroxyl has been acetylated (10‐fold) and that the carbonyl oxygen of the acetylated analogues is important, as its removal (to form the ethylether derivative) decreased affinity another 20‐fold. The presence of an aziridinium ring on the quaternary nitrogen in place of two methyl groups did not affect the blocking of transport at 10 min of inhibitor preincubation and replacement of a methyl group on the nitrogen by an ethyl group did not alter affinity for the high‐affinity carrier. The aziridinium ring on the nitrogen of the mustard analogues was important, however, in determining the extent of reversibility of the binding of these agents to the carrier protein. Choline transport was not restored by washing synaptosomes that were incubated with choline mustard aziridinium ion or monoethylcholine mustard aziridinium ion, but was readily obtained in washed synaptosomes preincubated with monoethylcholine, hemicholinium‐3, or pyrrolcholine. The results indicate that the mustard analogues may be potent alkylators of the high‐affinity choline carrier and thus, useful agents in monitoring acetylcholine turnover in systems where the carrier is blocked.
Estimating Natural Selection Acting on Stream‐Dwelling Atlantic Salmon: Implications for the Restoration of Extirpated Populations

Abstract: Efforts to restore populations to locations from which they have been extirpated may be hampered by maladaptation in the introduced group because they came from a different environment. Estimates of natural selection acting on the new population can be used to deduce maladaptation and tailor efforts to reduce its effects. We estimated natural selection acting on Atlantic salmon ( Salmo salar ) undergoing restoration to the Connecticut River ( U.S.A. ). More than 3500 mark‐recapture records in a small tributary ( West Brook, Massachusetts ) were used to estimate selection acting on body length, body mass, condition factor, and growth. Estimates were obtained for three to four different cohorts, two age classes ( second and third years of life ), and two seasons ( winter and summer ). We found little evidence that any of the traits were subject to strong directional selection ( favoring larger or smaller trait values ). Interestingly, fish that were larger or had higher condition factors rarely survived at higher rates, a result conflicting with the conventional “bigger is better” expectation. We also found little evidence that any of the traits were subject to strong or consistent stabilizing selection ( favoring trait values near the mean ). Our results suggest that the specific traits we examined are not limiting adaptation and are probably not preventing the population from becoming self‐sustaining. Future efforts should concentrate on other potentially limiting traits, such as the timing of smolt migration. Our results also suggest that any additional introductions of exogenous fish need not be concentrated on the size or growth of juveniles in potential source populations.
ND10 Protein PML Is Recruited to Herpes Simplex Virus Type 1 Prereplicative Sites and Replication Compartments in the Presence of Viral DNA Polymerase

ABSTRACT Herpes simplex virus type 1 (HSV-1) infection results in the disruption of ND10 (also called nuclear bodies, PODs, or PML-associated bodies), which are nuclear matrix domains of unknown function present in mammalian cells. After ND10 disruption, viral transcription and DNA replication occur in globular nuclear domains called replication compartments. In this report we define four stages of infection by using antibodies to ICP8 (also called SSB and UL29) and the ND10 antigen PML. Immediately after infection, cells contain intact ND10 as detected by staining for PMLs (stage I); within 1 hour, however, ND10 are disrupted and cells begin to exhibit diffuse staining for the major viral DNA binding protein, ICP8 (stage II). After all ND10 have been disrupted, foci which resemble but are not equivalent to ND10 appear, containing both PML and ICP8 (stage III). Cells infected with mutants defective in the helicase-primase or origin binding protein are unable to form stage III foci. Cells infected with a mutant that is null for the polymerase catalytic subunit, however, form stage III-like ICP8 foci which do not contain PML. Thus, stage III foci recruit the cellular PML protein in the presence but not the absence of HSV polymerase. PML was recruited to stage III foci in some but not all cells infected with a mutant defective in the polymerase accessory protein, UL42. Thus, UL42 is not required for the recruitment of PML to viral foci. In wild-type infection, stage III cells are quickly replaced by cells containing replication compartments (stage IV). PML and ICP8 staining are both observed within replication compartments, indicating a potential role for PML in HSV-1 replication. Models for the role of ND10 proteins in the formation of replication compartments are discussed.
Hatha yoga on body balance

Background: A good body balance requires a proper function of vestibular, visual, and somatosensory systems which can be reach with exercise practice and/or yoga. Aim: To determine the effects of a 5-month hatha yoga training program on body balance in young adults. Materials and Methods: This study used a controlled, nonrandomized design, where the experimental group underwent a 5-month training program and were then compared with the control group that had a sedentary lifestyle. A convenience sample of 34 out of 40 men aged 25-55 years old (34.0 ± 0.9) were deemed eligible for this study. They were randomly divided into two groups: Experimental and control groups. Subjects in the experimental group were engaged in 60 min sessions of hatha yoga three times a week for 5 months. We evaluated postural control by measuring the limit of stability and velocity of oscillation (VOS) in three conditions of the balance rehabilitation unit (BRU) and through field procedures (four position, plane, flamingo, hopscotch, and dynamic test). Results: We observed differences (P < 0.05) in postintervention scores between the groups regardless of BRU parameters and field procedures (except for flamingo) even after adjusting for preintervention scores, suggesting that these changes were induced by hatha yoga training. The partial eta squared on BRU parameters ranged from 0.78 (VOS1)-0.97 (COP2), and from 0.00 (flamingo)-0.94 (four position) for the field procedures. Conclusions: Our results provide substantial evidence that postural control in healthy young adults can be improved through practicing hatha yoga.
Outcomes of patients with cystic fibrosis undergoing lung transplantation with and without cystic fibrosis‐associated liver cirrhosis *

Nash EF, Volling C, Gutierrez CA, Tullis E, Coonar A, McRae K, Keshavjee S, Singer LG, Durie PR, Chaparro C. Outcomes of patients with cystic fibrosis undergoing lung transplantation with and without cystic fibrosis‐associated liver cirrhosis. Clin Transplant 2012: 26: 34–41. © 2011 John Wiley & Sons A/S.
DNA Immunotherapies for Type 1 Diabetes

vaccines, monoclonal antibodies, and other adjuvant agents that have shown synergistic effects. In one possible scenario, autoantigen-specific immunotherapies could be used over the long-term as stand-alone treatments, with the occasional help of systemic immune modulators depending on disease severity. Regardless of the strategy to be chosen, there is a strong case to be made for including plasmid DNA immunotherapy in future treatments of type 1 diabetes.
Validity and Reliability of the Eysenck Personality Inventory with Outpatients

A validity and reliability study of the Eysenck Personality Inventory, Form A and Form B, is reported for 274 females and 303 male outpatients attending a community mental health center. Findings were similar to those published for randomized samples. The present study helped to sustain interest in the inventory as a research tool with psychological outpatients.
Tool support for traceability management of software artefacts with DevOps practices

Software development process encompasses multiple types of and differentiated versions of artefacts during the corresponding lifecycle. These artefacts are vulnerable to artefact drift or erosion when the product being developed gets changed. As a result different artefacts are subject to differential rates of updates compared to each other. Managing the software artefacts is one of the major problems in software industry. When the software process evolves the inconsistencies between artefacts also be evolve and it occurs within different rates. Traceability between software artefacts is considered as a very important factor in today development process. Traceability between artefacts helps the software professionals to track back and forth between artefacts. In order to identify and visualize different relationships between a selected set of software artefact types, Software Artefacts Traceability Analyzer (SAT-Analyzer) was designed and developed. This tool at present is supporting traceability management for requirement specification, design specification and source code. In this paper the work carried out extending SAT Analyzer to support DevOps practices with traceability. This research has considered the Testing artefacts, Configuration artefacts and Deployment artefacts for traceability management within DevOps practices. Adding continuous integration support to this tool is a main area of work as part of the research. Hence SAT Analyzer is linked with Jenkins continuous integration tool. At the same time the existing visualization of SAT Analyzer was enhanced to support DevOps related operations and testing, configuration and deployment traceability links. The evaluation of the modified SAT Analyzer was carried out with a case example and discussed in the paper.
Alcalosis posthipercápnica en pacientes con enfermedad pulmonar obstructiva crónica exacerbada

La alcalosis posthipercapnica (APH) es una complicacion frecuente de la ventilacion mecanica (AMV) en pacientes con EPOC exacerbado. Metodologia: Estudio retrospectivo de 232 expedientes con EPOC exacerbado; se seleccionaron los 30 que requirieron AMV y se excluyeron 10 por ser AMV no invasiva. Resultados: Edad promedio: 74 ± 11 anos, APACHE: promedio 18 ± 7 (8-38), 13 hombres (65%); 16 sobrevivieron, mortalidad: 20%. Se dividieron en pacientes sin PHA (n = 11, 55%) y con PHA (n = 9, 45%). Se obtuvo CO2 previo a AMV: 70 ± 27 (31-114) y 87 ± 11 (68-99) en pacientes sin PHA y con PHA respectivamente (p = 0.09), dia 1: 44 ± 6 (30-50) y 61 ± 19 (35-89) con p = 0.01, dia 3 y 6 sin diferencia signifi cativa. HCO3: los valores significativos fueron el dia 1, 3 y 6: dia 1, 26 ± 3.9 vs 37 ± 7, p = 0.0001, dia 3: 27 ± 4 vs 38 ± 5.5, p = 0.0001 y dia 6: 30 ± 5 vs 41 ± 6, p = 0.0001. Mortalidad: 18.2% y 22.2% con PHA y sin PHA respectivamente, sin diferencia. La estancia hospitalaria fue de16 ± 4 vs 26 ± 15 y p = 0.04. Conclusiones: Pacientes con EPOC y PHA tienen mayor estancia hospitalaria y dias de AMV. Hay incremento persistente del bicarbonato, sin relacion a cambios en el PaCO2, diureticos, perdida gastrointestinal o administracion de HCO3
The 10-year follow-up of a randomised trial of long-chain polyunsaturated fatty acid supplementation in preterm infants: effects on growth and blood pressure

Objective To test the hypothesis that consumption of infant formulas containing long-chain polyunsaturated fatty acids (LCPUFAs) by preterm infants would favourably influence growth, body composition and blood pressure (BP) at age 10 years. Methods This was a follow-up study of a preterm cohort (<35 weeks and birth weight <2000 g) randomly assigned to unsupplemented or LCPUFA-supplemented formulas to 9 months post term. The setting was a research clinic at Yorkhill Hospital for Sick Children, Glasgow, UK. A total of 107 children aged 9–11 years who participated in the original randomised controlled trial (45% follow-up) took part. Main outcome measures were: (1) anthropometry, (2) body composition and (3) BP. Results There were no differences in growth or BP between randomised groups for the whole cohort. However, girls who had received LCPUFA-supplemented formula were heavier (42.20 (SD 9.61) vs 36.94 (9.46) kg, p=0.05), had greater skin fold thicknesses (biceps 10.7 (3.3) vs 8.5 (3.6) mm, p=0.03; suprailiac 16.7 (8.2) vs 12.0 (7.5) mm, p=0.03) and higher BP (mean 82.2 (8.4) vs 78.1 (6.2) mm Hg, p=0.04: systolic 111.4 (10.1) vs 105.9 (9.0) mm Hg, p=0.04: diastolic 64.8 (8.4) vs 61.1 (5.4) mm Hg, p=0.05). Differences in weight SD score (0.85 (95% CI 0.13 to 1.58), p=0.02), Ln sum of skin fold thicknesses (0.27 (0.02 to 0.52), p=0.04) and BP (mean 4.6 mm Hg (0.43 to 8.84), p=0.03; systolic 6.1 (0.45 to 11.7), p=0.04) remained after adjustment for prerandomisation confounders. Differences in BP were not significant following adjustment for current weight. Conclusions Girls born preterm and randomised to LCPUFA-supplemented formula showed increased weight, adiposity and BP at 9–11 years, which might have adverse consequences for later health. No effects were seen in boys. Long-term follow-up of other LCPUFA supplementation trials is required to further investigate this finding.
A Look into the Concept of Diphthongisation in Bantu: A Case of Shona

This is a qualitative analysis of the traditional position in theoretical linguistics that Bantu languages have only monophthong vowels. It assesses the pronunciation of some of the typical Shona syllables involving vowels that do not qualify to be treated as monophthongs by some Shona speakers in Harare and Masvingo provinces where Zezuru and Karanga varieties of the language are traditionally spoken. It argues that vowels used in such environments are similar to their counterparts that are treated as diphthongs in certain English environments. The overall position is that the general resolution that has been made long ago (that Bantu languages do not have diphthongs and triphthongs) qualifies to be treated as one of the implicational universals that have been made on the languages which need to be dismissed right away. The paper observes that in the beginning such vowels might have been pronounced as chains of vowels but not anymore probably due to the language’s constant contact with Romance languages like English. The research recommends the carrying out of more researches to determine the position of such implicational universal resolutions on Bantu languages Keywords : Diphthongs, Monophthongs, triphthongs, Bantu language