Miracle-dz/UniFAR-FTUs huggingface dataset:
Hepatitis C virus type 1b (II) infection in France and Italy. Collaborative Study Group.

OBJECTIVE To analyze the distribution of hepatitis C virus (HCV) genotypes among patients positive for antibody to HCV (anti-HCV) according to age, severity of liver disease, and duration of infection; to investigate the influence of HCV genotypes on response to interferon-alpha therapy; and to study HCV viremia levels in relation to genotypes and severity of liver disease. DESIGN Cross-sectional study. SETTING 3 university hospitals and 2 research units. PATIENTS 3 groups of French and Italian patients with chronic HCV infection and detectable serum HCV RNA: Group 1 included 35 patients with hepatocellular carcinoma; group 2, 71 patients with cirrhosis who did not have hepatocellular carcinoma; and group 3, 114 patients with chronic active hepatitis. 106 of the patients with chronic hepatitis or cirrhosis were treated with interferon-alpha (3 MU subcutaneously 3 times/wk for > or = 6 months). MEASUREMENTS Genotyping by polymerase chain reaction with capsid-specific primers; serum HCV RNA by branched DNA (bDNA) signal amplification. RESULTS Hepatitis C virus genotype 1b (II) was the most prevalent genotype (61.8%). In a univariate analysis, it was associated with older age (< 40 years, 47.4%; > or = 60 years, 80.4%; P = 0.001), longer duration of disease (< or = 10 years, 40.4%; > or = 20 years, 86.7%; P = 0.005), and cirrhosis with or without hepatocellular carcinoma (78.4% compared with 53.8% for chronic hepatitis; P < 0.001). Viremia levels did not differ between patients infected with HCV type 1b (II) and those infected with other HCV genotypes. Patients with HCV type 1b (II) responded to interferon-alpha therapy significantly less than did patients with other HCV genotypes (P = 0.01). In a multivariate analysis, age and cirrhosis were independently associated with HCV genotype 1b (II). Genotype and HCV viremia level were independent predictors of response to interferon-alpha therapy. CONCLUSIONS The prevalence of HCV genotypes in French and Italian patients has been changing; the prevalence of HCV type 1b (II) infection has progressively decreased, although it still accounts for most HCV-related cirrhosis and hepatocellular carcinoma. High HCV viremia levels and HCV genotype type 1b (II) are independent predictors for poor response to interferon-alpha therapy and should be considered in the management of patients with HCV infection.
(2SR,3SR)-Isopropyl 3-{[dimethyl(phenyl)silyl]methyl}-2-hydroxy-2-vinylpent-4-enoate

The relative configuration of the title compound, C19H28O3Si, which was synthesized using a dienolate-[2,3]-Wittig rearrangement, was corroborated by single-crystal X-ray diffraction analysis. The Si—C bond distances are in the range 1.858 (2)–1.880 (2) Å and an intramolecular O—H⋯O hydrogen bond helps to stabilize the molecular conformation.
Role of hypoxia‐inducible factor‐1α expression in regulatory T cells on nasal polypogenesis

Hypoxia‐inducible factor‐1α (HIF‐1α) is considered as a key molecule in regulating Th17:regulatory T‐cells (Tregs) balance. The aims of this study were to investigate whether HIF‐1α is associated with the RORγ (RAR‐related orphan receptor gamma) expression of Tregs in nasal polyps and to verify whether Staphylococcus enterotoxin B (SEB) is involved in this process.
Langzeitergebnisse nach operativer Dekompression des Sulcus-ulnaris-Syndroms

In dieser Studie wurden die Langzeitergebnisse nach operativer Dekompression des Sulcus-ulnaris-Syndroms untersucht. Die praoperativen Daten wurden aus den Akten entnommen, die postoperativen Daten mittels Fragebogen durch telefonische Interviews erhoben. Parameter waren praoperativen Befunde, Dauer der postoperativen Beschwerden und zum Zeitpunkt des Interviews noch bestehende Beschwerden. Die Ergebnisse der Studie zeigen einen Zusammenhang zwischen dem praoperativen Schweregrad des Sulcus-ulnaris-Syndroms und dem Operationsergebnis. Es wurde eine neue Einteilung des Sulcus-ulnaris-Syndroms vorgenommen, in die auch elektrophysiologische Untersuchungsergebnisse einfliesen.
MORAL DISTRESS AND PSYCHOLOGICAL EMPOWERMENT IN CRITICAL CARE NURSES CARING FOR ADULTS AT END OF LIFE

Background Critical care nurses providing care for adults at the end of life may encounter moral distress when they cannot do what they believe is ethically correct. Psychological empowerment can decrease moral distress among critical care nurses. Objectives To describe the relationships between moral distress, psychological empowerment, and demographics in critical care nurses caring for patients at the end of life. Method A total of 277 critical care nurses were surveyed via the Moral Distress Scale and the Psychological Empowerment Instrument. Responses were scored on a Likert scale of 1 to 7. Results Moral distress intensity was high (mean 5.34, SD 1.32) and positively correlated with age (r = 0.179, P = .01). Moral distress frequency was moderate (mean 2.51, SD 0.87) and negatively correlated with nurses’ collaboration in end-of-life patient care conferences (r = -0.191, P = .007). Psychological empowerment scores (mean 5.31, SD 1.00) were high and positively correlated with age (r = 0.139, P = .03), years of experience (r = 0.165, P = .01), collaboration in end-of-life-care conferences (r = 0.163, P = .01), and end-of-life-care education (r = 0.221, P = .001) and were negatively correlated with moral distress frequency (r = -0.194, P = .01). Multiple regression analysis revealed that empowerment was a significant predictor of moral distress frequency (β= .222, P < .01). Conclusion The significant negative correlation between psychological empowerment and frequency of moral distress in these nurses indicated that nurses with higher perceived empowerment experience moral distress less often. This finding is of particular interest as interventions to decrease moral distress are sought. (American Journal of Critical Care. 2013;22:143-152) MORAL DISTRESS AND PSYCHOLOGICAL EMPOWERMENT IN CRITICAL CARE NURSES CARING FOR ADULTS AT END OF LIFE
Immunology of respiratory syncytial virus infection: eosinophils, cytokines, chemokines and asthma

The severity of illness at the time of respiratory syncytial virus (RSV) infection undoubtedly represents the summation of a variety of factors. The risk of developing lower respiratory illness (LRI) at the time of infection is related to several measures of socioeconomic status, particularly crowding. This suggests that the quantity of virus with which an individual is inoculated is an important contributing factor to the outcome of infection. In addition infants whose airflow is somewhat limited in comparison with other infants of the same age are more likely to develop virusinduced wheezing illnesses in the first few years of life. 3 There is also evidence that the immune response to RSV infection plays a part in determining the development of LRI. The magnitude of RSV-specific antibody responses in the IgG, IgM and IgA isotypes in infants who develop LRI at the time of RSV infection is similar to that in infants whose illness is restricted to the upper respiratory tract. In contrast RSV-specific IgE antibody responses occur in many infants with RSV infection and may be quantitatively greater in those who develop wheezing. 7 Lymphoproliferative responses to RSV antigen are at least as strong in infants with bronchiolitis as they are in those with upper respiratory infection (URI) alone. 11 Therefore bronchiolitis does not appear to occur as a result of a deficiency in humoral or cellular immunity. A fundamental current concept of asthma is that it represents an inflammatory disease of the airway. The asthmatic airway is infiltrated with activated T helper lymphocytes and eosinophils. 13 The migration of these cells to the airway is thought to be controlled by the beta-chemokines, among them macrophageinflammatory protein (MIP)1-alpha, eotaxin and regulated on activation, normal T cell expressed and secreted (RANTES). Furthermore the lymphocytes present in the airway in allergic asthma primarily produce interleukins (IL) 4 and 5 and, to a lesser extent, interferon gamma (IFN-gamma). IL-4 and IL-5 are believed to be important in asthma in that they are responsible for induction of IgE responses and assist in the chemotaxis and activation of eosinophils. Unique immunologic pathways involving eosinophils, beta-chemokines and those cytokines produced by type 2 helper (Th2) lymphocytes therefore appear to contribute to the pathogenesis of asthma. In this report we emphasize how similar aberrant responses may contribute to the development of RSV bronchiolitis.
Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors

Multiple regulatory domains within the -100 region of the beta interferon (IFN-beta) promoter control the inducible response of the IFN gene to virus infection. In this study, we demonstrate that the formation of NF-kappa B-specific complexes on the positive regulatory domain II (PRDII) precedes the onset of detectable IFN-beta transcription in Sendai virus-infected cells. By using NF-kappa B subunit-specific antibodies, a temporal shift in the composition of NF-kappa B subunits in association with the PRDII domain is detected as a function of time after virus infection. Furthermore, a virus-induced degradation of I kappa B alpha (MAD3) protein is observed between 2 and 8 h after infection; at later times, de novo synthesis of I kappa B alpha restores I kappa B alpha to levels found in uninduced cells and correlates with the down regulation of IFN-beta transcription. In cotransfection experiments using various NF-kappa B subunit expression plasmids and two copies of PRDII/NF-kappa B linked to a chloramphenicol acetyltransferase reporter gene, we demonstrate that expression of p65, c-Rel, or p50 or combinations of p50-p65 and p65-c-Rel differentially stimulated PRDII-dependent transcription. Coexpression of I kappa B alpha completely abrogated p65-, c-Rel-, or p65-p50-induced gene activity. When the entire IFN-beta promoter (-281 to +19) was used in coexpression studies, synergistic stimulation of IFN-beta promoter activity was obtained when NF-kappa B subunits were coexpressed together with the IFN regulatory factor 1 (IRF-1) transcription factor. Overexpression of either I kappa B or the IRF-2 repressor was able to abrogate inducibility of the IFN-beta promoter. Thus, multiple regulatory events--including differential activation of DNA-binding NF-kappa B heterodimers, degradation of I kappa B alpha, synergistic interaction between IRF-1 and NF-kappa B, and decreased repression by I kappa B and IRF-2--are all required for the transcriptional activation of the IFN-beta promoter.
Implementation of a low-cost and low-power batteryless transceiver SoC for UHF RFID and wireless power transfer system

This paper describes a low-power, high-performance RFID tag and wireless power transfer IC for according to the requirements of the EPC Class 1 Generation 2. Operating in the frequency ranges of 860 ~ 960 MHz, the reading operation of tag IC is the -15 dBm minimum power sensitivity. The tag IC consists of an analog part for modulation/demodulation/oscillation, a digital control logic part for controlling the transceiver functionality, and a 512-bit non-volatile memory (NVM) for storing EPC code and a unique identification number. The UHF RFID tag IC is implemented in the 0.18 μm CMOS standard technology. The overall power consumption is only 6 μW at 1.3 V supply voltage. The chip size is 610 μm × 615 μm.
Datapoints: acceptability of asking parents about their children's traumatic symptoms.

866 L is known about the effectiveness of mental health interventions to help child trauma victims. Concerns about the ethics of asking children and their families about the children’s traumatic experiences have hindered research in this area. Some studies have suggested that asking trauma victims about their experiences may increase their psychological distress (1), whereas others have shown that questioning does not significantly increase their distress (2). To understand the ethical issues, we measured the acceptability of asking parents of child trauma victims about their children’s traumatic experiences. As part of a larger study to assess the impact of a school-based mental health program in Los Angeles (3), 1,887 students in grades 3 to 8 completed self-report forms about violence exposure, posttraumatic stress disorder symptoms, and depressive symptoms. Parents of the 418 students who reported high rates of violence exposure and clinical levels of posttraumatic stress symptoms were interviewed about their children’s emotions and behavior, their knowledge and beliefs about the effects of violence on children, and their attitudes toward mental health treatment. At the end of the interview, parents were asked to assess their interview experience with a 5-point Likert scale. As Figure 1 shows, of the 418 parents who completed the interview, 369 (88 percent) reported that answering the questions was either a pleasant or somewhat pleasant experience. Only eight parents (2 percent) reported that it was either a somewhat unpleasant or unpleasant experience. Participating parents were primarily Latino (401 parents, or 96 percent) and female (337 parents, or 81 percent). No significant differences were found by parents’ race or ethnicity, education level, marital status, or employment status or by the severity of the children’s symptoms or the amount of violence that the children were exposed to. Acceptability of Asking Parents About Their Children’s Traumatic Symptoms
Physico-chemical characterization and kinetic study of methylene blue adsorption onto a Moroccan Bentonite

A Moroccan Benonite taken from a geological site in the North-Eastern Rif of Morocco has been characterized by XRF, CEC measurements, XRD, IRTF, SEM and N2 adsorption/desorption at -196 °C. The results showed that the structure of the purified bentonite (PB) is constituted exclusively of monmorillonite and some Mg and Fe cations replace Al in the octahedral sheet. The specific surface area developed is of 74 m g, and the diameters of pores are superior to 38 Å indicating the presence of mesopores. The adsorption study of methylene blue (MB) onto PB showed that the percentage removal of this molecule can reach 99.6%, and the amount of MB adsorbed depends closely on adsorbent dosage, pH and solution temperature. The results of the adsorption tests showed that the experimental data fitted very well the pseudo second order model. Also, it was found that for temperatures ≤ 45 °C, the adsorption process proceeds by surface adsorption followed by an internal diffusion into the particles with Ea=49.7 kJ.mol-1; while for temperatures ≥ 55 °C, it is governed by an internal diffusion into the particles with Ea = 2.3 kJ.mol. The low Ea values are characteristic of physical adsorption.
SPEARMAN’S HYPOTHESIS TESTED COMPARING SAUDI ARABIAN CHILDREN AND ADOLESCENTS WITH VARIOUS OTHER GROUPS OF CHILDREN AND ADOLESCENTS ON THE ITEMS OF THE STANDARD PROGRESSIVE MATRICES

Summary Spearman’s hypothesis tested at the level of items states that differences between ethnic groups on the items of an IQ test are a function of the g loadings of these items, such that there are small differences between ethnic groups on items with low g loadings and large differences between ethnic groups on items with high g loadings; this has been confirmed in a limited number of studies. In this paper, Spearman’s hypothesis was tested, comparing a group of Saudi children and adolescents (N=3209) with other groups of children and adolescents from Denmark, Cyprus, Croatia, Bosnia, South Africa, Estonia, Ukraine, Ireland, Russia and Chile (total N=9333). The analyses were carried out on twelve comparisons between the Saudi Arabian children and the other children. Spearman’s hypothesis was confirmed less strongly than in other large-scale studies with a mean weighted r value of 0.44. The relevance of these findings for the discussion on the causes of group differences is discussed.
The Exocytosis Regulator Synaptotagmin V Controls Phagocytosis in Macrophages1

Synaptotagmins (Syts) play a key role in the regulation of Ca2+-triggered exocytosis and membrane fusion events, two crucial events associated to the phagocytic process. In the present study, we investigated the role of Syt V, a regulator of focal exocytosis, in phagocytosis. In macrophages, Syt V is localized on recycling endosomes and on filopodia-like structures and is recruited to the nascent phagosomes independently of the phagocytic receptor engaged. Silencing of Syt V by RNA interference revealed a role for this protein for phagocytosis, particularly under conditions of high membrane demand. In contrast, silencing of Syt V had no effect on the recruitment of the lysosomal marker LAMP1 to phagosomes, indicating that phagosome maturation is not regulated by Syt V. Collectively, these results illustrate the importance of Syt V in the regulation of an important innate function of macrophages. Furthermore, our results are consistent with the concept that focal exocytosis of endocytic organelles is a key event in phagocytosis and suggest that Syt V regulates this process.
Ecological responses of Antarctic krill to environmental variability: can we predict the future?

Abstract Antarctic krill are a key species in the Southern Ocean ecosystem, and their life cycle appears to be correlated with, and by implication dependent upon, seasonal sea ice dynamics. Moving from correlations with environmental parameters to an understanding of the mechanisms that lead to these correlations may allow predictions of the consequences of climate change on the distribution of favourable habitat for Antarctic krill. During winter cruises in 2001 and 2002 in the region west of the Antarctic Peninsula, one of the most rapidly warming regions on the planet, ice camps were established for periods of 3–9 days. Timing of sea ice advance, chlorophyll a concentrations in ice cores, and growth rates and pigment content of larval krill all differed significantly between winters. Growth rates and pigment content of larval krill from the same ice floe were correlated, suggesting that growth rates in winter are a function of the biomass of the sea ice microbial community. Apossible mechanism underlying the correlation between recruitment success and timing of ice advance is proposed. In conjunction with other postulated habitat requirements, this proposed mechanism allows for speculation about future changes in the geographic location of favourable habitat for Antarctic krill.
Understanding 3D Mid-Air Hand Gestures with Interactive Surfaces and Displays: A Systematic Literature Review

3D gesture based systems are becoming ubiquitous and there are many mid-air hand gestures that exist for interacting with digital surfaces and displays. There is no well defined gesture set for 3D mid-air hand gestures which makes it difficult to develop applications that have consistent gestures. To understand what gestures exist we conducted the first comprehensive systematic literature review on mid-air hand gestures following existing research methods. The results of the review identified 65 papers where the mid-air hand gestures supported tasks for selection, navigation, and manipulation. We also classified the gestures according to a gesture classification scheme and identified how these gestures have been empirically evaluated. The results of the review provide a richer understanding of what mid-air hand gestures have been designed, implemented, and evaluated in the literature which can help developers design better user experiences for digital interactive surfaces and displays.
Content Recommendation System Based on Private Dynamic User Profile

Internet is overwhelming, personalized content recommendation system offers spam filtering service and suggests useful information to the end users. It is a hotspot in the research area of content management on WWW. Traditional recommendation systems do the data mining on web access logs, discover user's access patterns, and filter the information on behalf of the user at the server side. One critical limitation of traditional recommendation system is the lack of user's private daily data, such as schedules, favorite websites and personal emails. The reason for this limitation is the privacy leak issue when the server holds much more private user data. To solve this problem, this paper presents an agent-based personalized recommendation method called Content REcommendation System based on private Dynamic User Profile (CRESDUP). The system collects and mines the private data of user at the client side, discovers, stores and updates private Dynamic User Profile (DUP) at the client side. The system fetches preferred message from the content server according to DUP. An important usage of this technology is a personalized advertising system in the RSS (Rich Site Summary, or RDF Site Summary) reader application. Our experiment shows that the system can utilize DUP to identify the customers' potential preferences and deliver the more preferred messages, especially the advertisements, to people who are interested.
Factors Associated with the Development of Heterotopic Ossification in Two Different Types of Hip Prosthesis

The Authors evaluated the incidence and the dimensions of heterotopic ossifications (HO) in two groups of patients in which two different types of prosthesis were implanted. The first group of 31 patients had received an alumina-alumina Rosenthal-SAMO total hip replacement, while the second group (79 patients) had a metal-polyethylene Charnley low friction arthroplasty. While the total incidence of HO was similar, the HO were significantly smaller in the first group (all grade I according to Brooker)(3). The patients’ clinical files were retrospectively examined, but it was not possible to find any significant difference for the following parameters: age, sex, side, previous homolateral surgery, diagnosis, operating team, operating time, type of anaesthesia, and blood loss during surgery. The only difference was in the number of suction drains positioned: two in the first group and one in the second. Even if it is impossible to draw a definite conclusion, we postulate that the decrease in volume and duration of the periprosthetic haematoma, and the smaller amount of debris caused by the alumina-alumina coupling, could be of protective value.
LimeDS and the TraPIST Project: A Case Study

Real-Time Travel Information (RTTI) for rail commuters is still used inefficiently today and is rarely combined with other knowledge to come to a truly personalised and situation-aware multimodal travelling assistance. It is up to the travellers themselves to look for important info about their trip through static schedules or dedicated non-personalised applications. In a highly dynamic context such as that of public transportation, it would make life easier if one was able to consult the right information at the right time (removing superfluous information), for a variety of multimodal public transportation options, taking into account the context of the person travelling. In this paper we present the LimeDS framework, allowing application developers to rapidly define data workflows from a variety of data sources, deploy these workflows in a scalable and resilient manner and expose results to client applications as REST endpoints. A Proof-of-Concept (PoC) shows how our proposed framework can be used to tie together different open transportation data sources in order to create highly dynamic multimodal travel assistance applications by semantically enriching the data into knowledge, checking for ontological consistency and reason over the resulting knowledge.