Miracle-dz/UniFAR-FTUs huggingface dataset:
Phlegmasia cerulea dolens with compartment syndrome: A complication of femoral vein catheterization

Objective: Central venous catheterization is commonly performed in the critically ill. The femoral vein is widely accepted as an insertion site with complications thought to be comparable to other central access sites. We used serial ultrasound examinations with Doppler to examine the evolution of a heretofore undescribed complication of femoral vein catheterization, phlegmasia cerulea dolens with compartment syndrome. Design: Serial ultrasounds were performed in patients before the insertion of femoral venous catheters and sequentially every 48 hrs while the catheters were in place. The noncatheterized leg served as a control. Setting: A trauma and life support center of a tertiary multidisciplinary critical care unit. Patient: A 32‐yr‐old man with respiratory failure as a consequence of a severe community‐acquired pneumonia that required central venous access for antibiotics because no peripheral sites could be obtained. Interventions: None. Measurements and Main Results: The initial ultrasound examination of both legs before femoral catheter insertion revealed no sign of venous thrombosis. Ultrasound of the catheterized leg at 48 hrs revealed a small nonocclusive thrombosis, whereas the opposite leg remained normal. At 72 hrs, the catheterized leg had clinical and ultrasonographic evidence of a massive thrombosis. A compartment syndrome defined by pressure measurements soon ensued and required emergent surgical release. Conclusions: This case report and a review of the available literature suggest that thrombosis associated with femoral vein catheterization should be considered when clinicians decide where to obtain central venous access when multiple sites are available. This report also suggests the utility of serial ultrasound examinations to define clinically nonapparent thrombosis as an early indicator of a potentially catastrophic complication.
Identification of the substrate‐binding exosites of two snake venom serine proteinases: molecular basis for the partition of two essential functions of thrombin

The venom of the South American snake Bothrops jararaca contains two serine proteinases, bothrombin and the platelet‐aggregating enzyme PA‐BJ, which share 66% sequence identity. Each of these proteinases possesses one of the two essential procoagulant functions of thrombin—the clotting of fibrinogen and platelet aggregation. Thus, bothrombin clots fibrinogen but has no direct effect on platelets, unless in the presence of exogenous fibrinogen. PA‐BJ induces platelet aggregation by interacting with the protease‐activated platelet receptor without clotting fibrinogen. On the other hand, thrombin possesses two extended surfaces. One is composed of basic and hydrophobic residues (exosite I) and the other one of basic residues only (exosite II). These exosites are involved in the recognition of physiological macromolecular substrates. In order to identify the corresponding exosites in bothrombin and PA‐BJ and understand the molecular basis of the partition of the two procoagulant functions of thrombin among the two snake venom enzymes, we used molecular modeling to obtain models of their complexes with their natural substrates fibrinogen and a fragment of the protease‐activated platelet receptor, respectively. In analogy to thrombin, each of the enzymes presents two exosites. Nonetheless, the exosites contain a smaller proportion of basic residues than thrombin does (45–72%), reducing thus the functional diversity of the enzymes. In addition, the composition of exosite I is different in both enzymes. We identify those residues in exosite I that could contribute to the differences in specificity. Finally, allostery does not seem to mediate macromolecular substrate recognition by these enzymes. Copyright © 2003 John Wiley & Sons, Ltd.
A dual-slot diversity antenna with isolation enhancement using parasitic elements for mobile handsets

Isolation is a critical problem in the design of MIMO antennas and diversity antennas because it deteriorates the performance of multi-antenna system. In this paper, a dual-slot diversity antenna with isolation enhancement using parasitic elements for mobile handsets is presented. It consists of two symmetric slot elements. In order to improve the isolation, two parasitic monopole elements are added. The measured results show that the two slot elements are well matched in the whole UMTS band where the −6 dB criterion (VSWR ≪ 3) is satisfied. Meanwhile, across the band high isolation (S21 ≪ −18.5 dB) is obtained. Moreover, the antenna can provide pattern diversity to mitigate multipath fading.
Aid-Growth Association and Role of Economic Policies: New Evidence from South and Southeast Asian Countries

The present article aims to study the implications of foreign aid on GDP per capita in the seven middle-income countries of South and Southeast Asia from 1990 to 2016. The influence of foreign aid on GDP per capita is studied in a policy-driven environment, for which a policy index using government consumption expenditure, inflation and trade openness is constructed. The outcomes of the study confirm that aid–policy interaction has a significant and positive impact on economic growth in the region. The results are calculated using the two-stage least-squares model, as foreign aid is included as an endogenous variable in the study. This approach enables us to assess the indirect effect of monetary, fiscal and trade policies on GDP per capita, as the constructed policy index is used as an instrument for foreign aid. The results of the study ascertain that besides current aid–policy interaction, the preceding years’ aid–policy interaction also has a positive and significant impact on GDP per capita in the region. The inclusion of a policy index in the analysis enables us to evaluate the effectiveness of economic policies while determining the level of GDP per capita in South and Southeast Asian countries. Therefore, the study proposes that while assessing the influence of aid-financed programmes on GDP growth of a country, the economic policies of recipient countries need to be considered. The bottom line is that foreign aid, economic policies and economic growth of aid-recipient countries are inextricably linked.
Comparison of F1 Bos indicus x Hereford cows in central Texas: I. Reproductive, maternal, and size traits.

Cows (n = 116) sired by Angus, Gray Brahman, Gir, Indu-Brazil, Nellore, and Red Brahman bulls and from Hereford dams were evaluated (when bred to the same breed of bull) for reproductive performance and cow weight and height and their calves (n = 1,161) were evaluated for birth and weaning weight in central Texas (temperate winters and subtropical summers). Cows were born from 1982 to 1985 and their calves were born from 1985 to 1999. Crossbred cows sired by Angus had a higher (P < 0.10) occurrence of calving difficulty than Gir, Indu-Brazil, Nellore, and Red Brahman crossbreds. Calves from Gir crossbreds had lighter (P < 0.10) birth weight (34.8 kg) than calves from Angus and Red Brahman crossbreds (39.4 and 37.2 kg). Calves from Angus crossbreds cows had lighter (P < 0.001) weaning weight (227.0 kg) than calves from Bos indicus crossbreds. Cows sired by Angus were lighter (P < 0.10) as mature cows (520.69 kg) than Gray Brahman, Indu-Brazil, and Red Brahman crossbreds (585.6, 571.9, and 577.6 kg, respectively). They also had smaller (P < 0.05) hip height (124.7 cm) than Bos indicus crossbreds. Mature cows sired by Indu-Brazil had greater (P < 0.05) hip height (138.3 cm) than Gir crossbreds (133.8 cm). Differences among sire breeds were noted within cow age categories (2 through 14 yr of age) for pregnancy rate, calf crop born, calf survival rate (as a trait of cow), and calf crop weaned. Angus and Indu-Brazil crossbred cows were lower (P < or = 0.10) than Gir and Nellore crossbreds for pregnancy rate, calf crop born, and(or) calf crop weaned at some, but not all, ages. Indu-Brazil crossbreds had a lower (P < or = 0.10) calf survival rate than most other breed groups at ages 11 to 14 yr. The results of this study indicate that Nellore and Gir crossbreds, but not Indu-Brazil, could perform as well or better than breeds traditionally used in cross-breeding programs of U.S. cow-calf production.
Partial Randomness Hashing for Large-Scale Remote Sensing Image Retrieval

With the rapid progress of satellite and aerial vehicle technologies, large-scale remote sensing (RS) image retrieval has recently become an important research issue in geosciences. Hashing-based searching approaches have been widely employed in content-based image retrieval tasks. However, most hash schemes compromise between learning efficiency and retrieval accuracy, and can thus barely satisfy the precise requirements in RS data analysis. To address these shortcomings, we introduce a partial randomness scheme for learning hash functions, which is referred to as partial randomness hashing (PRH). Specifically, for constructing hash functions, a part of model parameter values are randomly generated and the remaining ones are trained based on RS images. The randomness enables an efficient hash function construction and the trained model parameters encode characteristics from RS images. The coplay between random and trained model parameters results in both efficient and effective learning scheme for constructing hash functions. Experiments on two large public RS image data sets have shown that our PRH method outperforms state of the arts in terms of both learning efficiency and retrieval accuracy.
Parallel TSQR-TLS and QR-TLS factorization for joint time delay and frequency estimation

In this paper we present two methods for joint estimation of time of arrival (TOA) and frequency of arrival (FOA) for multiple incident sources based on the subspace decomposition techniques called QR-TLS and TSQR-TLS. The proposed methods employ a pair of spatially separated sensors to receive the multiple incident source signals. A data matrix is constructed in a form of a Henkel matrix from the multiple snapshot of the received signal. The information of both TOA and FOA of the multiple incident sources is extracted from the data matrix by applying QR technique in the first method and a recent idea of tall skinny QR (TSQR) factorization in the second method. The estimates of the TOA and FOA are obtained from the signal subspace by applying total least squares (TLS) method. The simulation results are presented to assess the performance of the proposed method. The effect of parametric variations on the performance has also been analyzed. Further, the computational times of the proposed methods are also compared with each other.
Patients' outlook, experience, and satisfaction with hysterectomy, bilateral oophorectomy, and subsequent continuation of hormone replacement therapy.

OBJECTIVE Our purposes were to investigate patients' opinions of hysterectomy, bilateral oophorectomy, and hormone replacement therapy and to evaluate whether their outlook and experience influenced the overall satisfaction and continuation of hormone replacement therapy. STUDY DESIGN We conducted a questionnaire survey of 200 patients before and 2 years after hysterectomy with or without bilateral oophorectomy. Postoperatively all patients received long-term estradiol and testosterone replacement. The inquiries of patients' views included (1) preoperative awareness of indication and outlook, (2) postoperative recovery, symptom relief, and experiences with hormone replacement therapy, (3) perceived benefits and problems, (4) changes in physical well-being, psychologic state, and sexual activity, (5) continuation of hormone replacement therapy, and (6) overall satisfaction. RESULTS The outlook toward hysterectomy, bilateral oophorectomy, and hormone replacement therapy was positive in 77.4%, 87.1%, and 76.3%, respectively. The experience was positive in the majority, with a satisfactory postoperative recovery (70.6%), complete symptom relief (77.9%), and minimal side effects with hormone replacement therapy (5.2%). The benefits included improved physical well-being (79.9%), lower depressive symptoms (32.0%), and better sexuality (31.4%). The continuation rate of hormone replacement therapy was 97.4%, and overall satisfaction was positive in 88.7% of patients. The independent predictors of satisfaction were outlook toward hysterectomy and incomplete symptom relief. CONCLUSION The outcome of hysterectomy, bilateral oophorectomy, and hormone replacement therapy was satisfactory to most patients.
Diagnosis of venous access port-related infections.

The accumulation of infected clots under the silicone septum of the reservoir of venous access ports (VAPs) has been reported. We analyzed the relationship between these deposits and the occurrence of VAP-related bloodstream infections (VAP-BSIs) by (1) evaluating the accuracy of paired quantitative blood cultures for diagnosing VAP-BSI before the removal of the device and (2) assessing the accuracy of cultures of the tip and septum (i.e., the internal lumen of the VAP) for diagnosing VAP-BSI after removal of the device. Over a 16-month period, all VAPs removed were prospectively investigated. Before VAP removal, paired quantitative blood cultures were 77% sensitive and 100% specific and had a positive predictive value of 100% and a negative predictive value of 98% for diagnosing VAP-BSI. After VAP removal, tip culture was only 46% sensitive, whereas septum culture was 93.3% sensitive for confirming the diagnosis of VAP-BSI. Thus infected deposits that accumulate under the VAP septum are the source of VAP-BSI.
JRC PESETA III Project: Economic integration and spillover analysis

This report details the economic integration of the biophysical impact results of the JRC PESETA III project. Six impact areas have been fully integrated: labour productivity, river floods, coastal floods, energy, agriculture and human mortality due to heatwaves. A second objective of the economic task has been to explore the degree to which climate impacts cross geographical borders, the so-called spillover analysis. The global transboundary analysis has been made for the four sectors for which global impact estimates are available: labour productivity, river floods, energy, and agriculture. This document presents the methodology and main results of the economic assessment.
Lamin A and lamin C form homodimers and coexist in higher complex forms both in the nucleoplasmic fraction and in the lamina of cultured human cells

We have investigated and quantified the nuclear A-type lamin pool from human HeLa S3 suspension cells with respect to their distribution to detergent soluble and insoluble fractions. We devised a sequential extraction protocol and found that maximally 10% of A-type lamins are recovered in the soluble fraction. Notably, lamin C is enriched in low detergent fractions and only with 0.5% Nonidet P-40 lamin A and C are recovered in ratios nearly equivalent to those found in whole cell extracts and in the lamina fraction. Authentic nucleoplasmic proteins such as LAP2a, pRB and p53 are co-extracted to a large part together with the A-type lamins in these fractions. By sucrose density centrifugation we revealed that the majority of lamins co-sedimented with human IgG indicating they form rather small complexes in the range of dimers and slightly larger complexes. Some lamin A - but not lamin C - is obtained in addition in a much faster sedimenting fraction. Authentic nuclear proteins such as PCNA, p53 and LAP2a were found both in the light and the heavy sucrose fractions together with lamin A. Last but not least, immunoprecipitation experiments from both soluble fractions and from RIPA lysates of whole cells revealed that lamin A and lamin C do not form heterodimers but segregate practically completely. Correspondingly, immunofluorescence microscopy of formaldehyde-fixed cells clearly demonstrated that lamin A and C are localized at least in part to distinct patches within the lamina. Hence, the structural segregation of lamin A and C is indeed retained in the nuclear envelope to some extent too.
In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in corticobasal degeneration

Corticobasal degeneration (CBD) is a neurodegenerative parkinsonian disorder of unknown cause that shows considerable clinical heterogeneity. In CBD, activated microglia have been shown to be associated closely with the extensive tau pathology found in the affected basal ganglia, brainstem nuclei, and cortical regions. We report on the use of [11C](R)‐(1‐[2‐chlorophenyl]‐N‐methyl‐N‐[1‐methylpropyl]‐3‐isoquinoline carboxamide) (PK11195) positron emission tomography (PET), a marker of peripheral benzodiazepine binding sites (PBBS) that are expressed by activated microglia, to demonstrate in vivo the degree and distribution of glial response to the degenerative process in 4 patients with CBD. Compared with normal age‐matched controls, the CBD patient group showed significantly increased mean [11C](R)‐PK11195 binding in the caudate nucleus, putamen, substantia nigra, pons, pre‐ and postcentral gyrus, and the frontal lobe. [11C](R)‐PK11195 PET reveals a pattern of increased microglial activation in CBD patients involving cortical regions and the basal ganglia that corresponds well with the known distribution of neuropathological changes, which may therefore help to characterize in vivo the underlying disease activity in CBD. © 2004 Movement Disorder Society
Una visión crítica del problema de indeterminación de la distribución del ingreso en el sistema económico de Piero Sraffa

The model by Piero Sraffa (Sraffa (1960)) proposes and indeterminacy in the distribution of income, which has important implications since its arbitrary determination modifies relative prices among goods. This paper shows that when we include equations of production and the Ramsey´s 1928 model of demand for goods, the indeterminacy of the Sraffian system disappears provided there is full employment of labor. Relative prices of goods in terms of wages are determined as a variant of the labor theory of value, nonetheless.
An Atopy-Associated Polymorphism in the Ectodomain of the IL-4Rα Chain (V50) Regulates the Persistence of STAT6 Phosphorylation1

Several commonly occurring polymorphisms in the IL-4Rα have been associated with atopy in humans; the Q576R and the S503P polymorphisms reside in the cytoplasmic domain, whereas the I50 to V50 polymorphism resides in the extracellular domain of the IL-4Rα. The effects of these polymorphisms on signaling remain controversial. To determine the effect of the polymorphisms on IL-4 signaling in human cells, we stably transfected the human monocytic cell line U937 with murine IL-4Rα cDNA bearing the I or V at position 50 and the P503/R576 double mutant. Each form of the murine IL-4Rα mediated tyrosine phosphorylation of STAT6 in response to murine IL-4 treatment similar to the induction of tyrosine phosphorylation by human IL-4 signaling through the endogenous human IL-4Rα. After IL-4 removal, tyrosine-phosphorylated STAT6 rapidly decayed in cells expressing I50 or P503R576 murine IL-4Rα. In contrast, STAT6 remained significantly phosphorylated for several hours after murine IL-4 withdrawal in cells expressing the V50 polymorphism. This persistence in tyrosine-phosphorylated STAT6 was associated with persistence in CIS mRNA expression. Blocking IL-4 signaling during the decay phase using the JAK inhibitor AG490 or the anti-IL-4Rα Ab M1 abrogated the persistence of phosphorylated STAT6 observed in the V50-IL-4Rα-expressing cells. These results indicate that the V50 polymorphism promotes sustained STAT6 phosphorylation and that this process is mediated by continued engagement of IL-4Rα, suggesting enhanced responses of V50 IL-4R when IL-4 is limiting.
Robust Scheduling and Power Control for Vertical Spectrum Sharing in STDMA Wireless Networks

We study the robust transmission scheduling and power control problem for spectrum sharing between secondary and primary users in a spatial reuse time-division multiple access (STDMA) network. The objective is to find a robust minimum-length schedule for secondary users (in terms of time slots) subject to the interference constraints for primary users and the traffic demand of secondary users. We consider the fact that power allocation based on average (or estimated) link gains can be improper since actual link gains can be different from the average link gains. Therefore, transmission of the secondary links may fail and require more time slots. We also consider this demand uncertainty arising from channel gain uncertainty. We propose a column generation-based algorithm to solve the scheduling and power control problem for secondary users. The column generation method breaks the problem down to a restricted master problem and a pricing problem. However, the classical column generation method can have convergence problem due to primal degeneracy. We propose an improved column generation algorithm to stabilize and accelerate the column generation procedure by using the perturbation and exact penalty methods. Furthermore, we propose an efficient heuristic algorithm for the pricing problem based on a greedy algorithm. For the simulation scenario considered in this paper, the proposed stabilized column generation algorithm can obtain the optimal schedules with 18.85% reduction of the number of iterations and 0.29% reduction of the number of time slots. Also, the heuristic algorithm can achieve the optimality with 0.39% of cost penalty but 1.67×10-4 times reduction of runtime.
Blood flow in functional cysts and benign ovarian neoplasms in premenopausal women.

To assess the value of transvaginal color Doppler sonography in the differentiation of functional cysts from benign ovarian neoplasms in premenopausal women, 100 premenopausal women with the diagnosis of adnexal mass were enrolled in a prospective study. All patients underwent transvaginal color Doppler sonography during the follicular phase. We evaluated 107 masses. Tumor volume and morphology were assessed, as were tumor blood flow location, the number of vessels, the resistive and pulsatility indices, and the peak systolic velocity. Patients were followed up after 8 to 10 weeks by transvaginal sonography. Functional cysts were considered when spontaneous resolution occurred. Surgery was performed if a tumor enlarged or persisted after two scans. Thirty‐nine (36.5%) cysts regressed spontaneously and 68 (63.5%) were removed surgically. Seven of the latter were follicular or luteal cysts and were considered to be functional cysts. No carcinoma was found. Arterial blood flow was detected in 28 (60.8%) functional cysts and in 42 (68.8%) benign neoplasms (P = 0.3446). The vessels were located peripherally in 27 (94.6%) functional cysts and in 37 (88.1%) benign neoplasms (P = 0.2226). No differences were found between functional cysts and benign neoplasms in mean resistive index (0.65, 95% confidence interval: 0.59 to 0.71 versus 0.64, 95% confidence interval: 0.60 to 0.69), mean pulsatility index (1.47, 95% confidence interval: 1.17 to 1.84 versus 1.57, 95% confidence interval: 1.26 to 1.86), number of vessels (1.1, 95% confidence interval: 0.7 to 1.3 versus 1.4, 95% confidence interval: 1.1 to 1.8), and peak systolic velocity (28.6 cm/s, 95% confidence interval: 24.7 to 34.2 versus 24.9 cm/s, 95% confidence interval: 21.6 to 28.3). We concluded that transvaginal color Doppler sonography is not useful to discriminate between functional ovarian cysts and benign ovarian neoplasms in premenopausal women.