Miracle-dz/UniFAR-FTUs huggingface dataset:
Model for Educational Game Using Natural User Interface

Natural User Interface (NUI) is a new approach that has become increasingly popular in Human-Computer Interaction (HCI). The use of this technology is widely used in almost all sectors, including the field of education. In recent years, there are a lot of educational games using NUI technology in the market such as Kinect game. Kinect is a sensor that can recognize body movements, postures, and voices in three dimensions. It enables users to control and interact with game without the need of using game controller. However, the contents of most existing Kinect games do not follow the standard curriculum in classroom, thus making it do not fully achieve the learning objectives. Hence, this research proposes a design model as a guideline in designing educational game using NUI. A prototype has been developed as one of the objectives in this study. The prototype is based on proposed model to ensure and assess the effectiveness of the model. The outcomes of this study conclude that the proposed model contributed to the design method for the development of the educational game using NUI. Furthermore, evaluation results of the prototype show a good response from participant and in line with the standard curriculum.
Unilateral visual impairment and health related quality of life: the Blue Mountains Eye Study

Background: There has been considerable recent interest in the impact of unilateral visual impairment on functional status and wellbeing, particularly in relation to second eye cataract surgery. Aim: To determine if unilateral visual impairment has a measurable impact on health related quality of life (HRQOL) in an older community, as assessed by the generic, multidimensional 36 item short form health survey (SF-36). Methods: All participants of the second cross sectional Blue Mountains Eye Study (n = 3508) were invited to attend comprehensive eye examinations and complete an SF-36 questionnaire. Unilateral visual impairment was defined as visual acuity (VA) <6/12 in the worse eye and ≥6/12 in the better eye. Mild visual impairment was defined as VA <6/12 but ≥6/24, moderate as VA <6/24 but ≥6/60, and severe (blindness) as VA <6/60 in the worse eye. Cases with amblyopia (n = 48) were excluded. Results: Complete data were available for 3108 participants; 227 (7.3%) had unilateral visual impairment (148 mild, 29 moderate, 50 severe). Moderate to severe non-correctable unilateral impairment was associated with poorer SF-36 profiles. After adjusting for age and sex, this group had significantly poorer scores than the unimpaired group in three of eight domains (p<0.05); limitations as a result of physical problems, social function, limitations because of emotional problems, and in the mental component score. Mental domains were more affected than physical domains. Unilateral impairment from undercorrected refraction did not measurably affect HRQOL. Conclusions: Moderate to severe non-correctable unilateral visual impairment caused by eye diseases such as cataract had a measurable impact on HRQOL.
An Epidemiologic Approach to the Study of Acute Reversible Health Effects in the Workplace

We present an epidemiologic approach for the study of the irritant effects of sodium horate exposure that can he used to study acute reversible health effects more generally. Acute irritant responses, such as symptoms of nasal irritation or cough, are subjective. They may, however, be accompanied by transient airway obstruction, which can be objectively measured by a change in peak expiratory flow (PEF) or forced expiratory volume in one second (FEY). Because these physiologic responses are reversible and follow short-term peaks of exposure, they cannot be studied effectively using conventional epidemiologic methods of design and analysis. The proposed study design is a short-term prospective cohort study with frequently repeated measures of health effects and simultaneous measures of exposure. Because each subject passes through periods of high and low short-term exposure, the study has the form of a crossover design. This design permits each acute response to be linked to the corresponding short-term average exposure, providing the data necessary for dose-response analyses within subject. We present the results of the sodium borate study to illustrate the analysis of such data
Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity

Purpose. Brain-derived neurotrophic factor (BDNF) and basic fibroblast growth factor (bFGF) hold much promise for the protection of retinal ganglion cells against excitotoxic cell death. We tested the possibility of delivering these growth factors to retinal ganglion cells via an adeno-associated viral (AAV) vector and tested their efficacy in two models of excitotoxicity. Methods. Rat retinas were infected with AAV vectors encoding bFGF or BDNF. A control vector containing green fluorescent protein (GFP) was injected in the contralateral eye. Eyes were subjected to either an intravitreal injection of N-methyl-D-aspartate (NMDA) or optic nerve crush, and ganglion cell survival was evaluated. Results. AAV.CMV. bFGF and AAV.CBA. BDNF were neuroprotective against NMDA injection 1 month post-treatment. Additionally, AAV.CMV. bFGF was protective against optic nerve crush. Conclusion. AAV-mediated delivery of bFGF and BDNF can promote retinal cell survival following excitotoxic insult.
Vascular bed-specific hemostasis: Role of endothelium in sepsis pathogenesis

ObjectivesTo examine the role of vascular bed-specific pathways in determining the hemostatic phenotype in sepsis. Data Sources/Study Selection Published research and review articles related to hemostasis and endothelial cell biology. Data Extraction and Synthesis The results of published studies have been used to generate a hypothesis of vascular bed-specific hemostasis in sepsis. ConclusionsIn sepsis, coagulation is initiated by the extrinsic pathway and is amplified through the intrinsic pathway. In addition, the body’s natural anticoagulant mechanisms are significantly dampened. Together, these changes result in a net imbalance of hemostasis. The nature of this imbalance varies from one vascular bed to the next according to the local set point of the endothelium. These concepts lay an important foundation for understanding the pathophysiology of sepsis.
Controller performance assessment for multivariate switched systems: A tensor-product representation approach

This paper presents the tensor-product representation approach of multivariate switched linear systems for controller performance assessment, based on a suitable tensor-product representation of vectors and matrices. We obtain a representation theorem for multivariate switched linear systems. And, the stability properties of the tensor-product representation are investigated in depth, achieving the important result that any stable switched system admits a stable tensor-product representation of finite dimension. Moreover, the switched control performance analysis is performed on the projectors, the result of which is used to represent the performance of multivariate switched control systems. Finally, a numerical example is to verify the effectiveness of the proposed approach.
Joint proportional fairness admission control and superposition coding for OFDMA networks

In this paper, we aim to design an OFDMA frame-based resource allocation scheme allowing the power consumption minimization, the throughput enhancement and the queue's stability. We have proposed a novel proportional fairness admission control strategy in order to guarantee the desired QoS for each user. To increase the number of admitted users, we investigate a joint superposition coding and admission control process permitting to further exploit the multiuser diversity. Furthermore, we have suggested a power and bandwidth allocation scheme permitting to minimize power consumption while ensuring buffer's stability and satisfying the QoS requirements of users in a heavy load context. Numerical studies are conducted to evaluate the performance of the proposed algorithms in terms of served user and power consumption.
Rapamycin reduces renal hypoxia, interstitial inflammation and fibrosis in a rat model of unilateral ureteral obstruction.

PURPOSE The purpose of this study was to explore effects of rapamycin on renal hypoxia, interstitial inflammation and fibrosis, and the expression of transforming growth factor β1 (TGF-β1), vascular endothelial growth factor (VEGF), Flk-1 and Flt-1 in a rat model of unilateral ureteral obstruction (UUO). METHODS Male Sprague-Dawley rats (n=36) were randomly divided into three groups (n=12 per group): sham surgery, UUO and UUO plus rapamycin (0.2 mg/kg/d). Serum creatinine (Scr), blood urea nitrogen, uric acid, triglycerides, cholesterol and 24-h urine protein levels were measured. The extent of interstitial fibrosis was determined by Masson's trichrome staining. ED-1 positive macrophages, type III collagen, hypoxia, TGF-1, VEGF, Flk-1, and Flt-1 mRNA and protein expressions were detected using immunohistochemical staining, real-time PCR and Western blot. RESULTS UUO induced an elevation in Scr, renal hypoxia, inflammation, interstitial fibrosis, TGF-β1, VEGF, Flk-1, and Flt-1 mRNA and protein expression levels (P < 0.05). Rapamycin alleviated the UUO-induced renal hypoxia, infiltration of inflammatory cells and tubulointerstitial fibrosis (at days 3 and 7). Rapamycin also down-regulated the UUO-induced elevated expression levels of TGF-β1 and Flt-1 mRNA and protein (P < 0.05). Rapamycin decreased VEGF mRNA and protein expression at day 3, and increased Flk-1 mRNA and protein expression at day 7, compared with the UUO group (P < 0.05). CONCLUSION Rapamycin shows beneficial effects by reducing UUO-induced renal hypoxia, inflammation and tubulointerstitial fibrosis.
Argentinadansk: Semantiske, syntaktiske og morfologiske forskelle til rigsdansk

Argentinadansk, som det i dag tales af efterkommerne til udvandringen fra Danmark mellem ca. 1890 og 1930, adskiller sig fra rigsdansk grammatisk, leksikalsk og fonologisk. I denne artikel praesenterer vi syv af disse grammatiske og leksikalske saertraek inden for bojnings- og afledningsmorfologi, leksikologi, semantik, frasik og syntaks. Mere praecist ser vi pa leksikalske indlan fra spansk, udvidet brug af ere verbalafledningen, semantisk-syntaktisk udvidelse i argentinadanske verbalfraser, forekomsten af subjektlose saetninger og overrepraesentationen af frasen mere eller mindre . Mens vi tilskriver disse traek kontakten med det samfundsmaessigt dominerende sprog spansk, mener vi, at den inkonsistens i det argentinadanske genussystem, som vi ogsa inkluderer som argentinadansk saertraek, skyldes en kontaktuafhaengig udvikling. Analyserne er baseret pa et mindre datasaet af 16 talere, men vi har ved behov udvidet med data fra hele Corpus of South American Danish, som er en del af LANCHART-korpusset ved Kobenhavns Universitet. Det overordnede mal med denne artikel er et forste skridt pa vejen til at beskrive argentinadansk og netop at pege pa, om de traek, der adskiller argentinadansk fra rigsdansk, er et resultat af en direkte pavirkning fra spansk. Ud over dette tager vi beskrivelsen af de argentinadanske saertraek som anledning til at diskutere, hvad der skal til for at kunne tilskrive argentinadansk status som varietet.
Keeping an Eye on Chlamydia and Gonorrhea Conjunctivitis in Infants in the United States, 2010-2015.

To the Editor: W e read with interest the analysis conducted by Kreisel et al., who examined the national rates of reported neonatal conjunctivitis due to Chlamydia trachomatis and Neisseria gonorrhoeae in the United States. The emphasis was concern over the efficacy of neonatal ocular prophylaxis, as erythromycin is the only available preparation available in the United States. Neonatal ocular prophylaxis with silver nitrate, topical erythromycin, or tetracycline ointment, although effective for prevention of gonococcal ophthalmia, does not prevent chlamydial ophthalmia or nasopharyngeal colonization with C trachomatis or chlamydial pneumonia. Prospective studies of mother-to-infant transmission of C trachomatis conducted in the 1970s and 1980s suggested that neonatal ocular prophylaxis with silver nitrate did not prevent chlamydial conjunctivitis, nasopharyngeal infection, or pneumonia, as silver nitrate was routinely used for neonatal ocular prophylaxis at the time of those studies. Hammerschlag et al. screened 4357 pregnant women for C trachomatis infection; 341 (8%) were positive. Their infants were randomized to receive 1% silver nitrate, erythromycin, or tetracycline ophthalmic ointments at birth; 230 infants were followed up for 3 months for conjunctivitis, nasopharyngeal infection, and/or chlamydia pneumonia. The incidence of chlamydial conjunctivitis in these infants was 20%, 14%, and 11%, respectively (P > 0.25). There were also no differences in the incidence of nasopharyngeal infection (in infants with conjunctivitis and asymptomatic infection) or subsequent development of chlamydia pneumonia. Prenatal screening and treatment of pregnant women is the most effective way
Detection and defense of DDoS attack–based on deep learning in OpenFlow‐based SDN

Distributed denial of service (DDoS) is a special form of denial of service attack. In this paper, a DDoS detection model and defense system based on deep learning in Software‐Defined Network (SDN) environment are introduced. The model can learn patterns from sequences of network traffic and trace network attack activities in a historical manner. By using the defense system based on the model, the DDoS attack traffic can be effectively cleaned in Software‐Defined Network. The experimental results demonstrate the much better performance of our model compared with conventional machine learning ways. It also reduces the degree of dependence on environment, simplifies the real‐time update of detection system, and decreases the difficulty of upgrading or changing detection strategy.
Onco-fertilité : Impact des facteurs influençant la réserve ovarienne après chimiothérapie

La chimiotherapie induit une baisse de la fertilite en exercant une toxicite directe sur les ovaires entrainant une diminution du stock ovocytaire. Couramment utilise dans le traitement du cancer du sein, le cyclophosphamide (Cy) est une des drogues reconnue comme la plus gonadotoxique. Recemment, il a ete propose que le Cy provoquait une depletion folliculaire par une entree en croissance massive des follicules au repos. L’Hormone Anti-Mullerienne (AMH) etant un des facteurs regulant la sortie des follicules primordiaux de la reserve ovarienne, nous avons emis l’hypothese que cette hormone pourrait limiter la gonadotoxicite du Cy. Nous avons montre qu’un traitement par AMH recombinante chez des souris puberes traitees par Cy, permettait effectivement de limiter la depletion folliculaire. Sur le plan fondamental, nous avons mis en evidence que l’autophagie pouvait etre un des mecanismes impliques dans l’inhibition du recrutement folliculaire exercee par l’AMH. Enfin, la methode de reference consistant a evaluer la reserve ovarienne chez la souris etant particulierement longue et fastidieuse, nous avons developpe une technique de comptage folliculaire automatise en utilisant des methodes d’intelligence artificielle, et plus particulierement une approche de « deep learning».
Safety of ultrasound contrast agents: “Primum non nocere”?

In Belgium,UCA are refunded when ultrasound echocardiographywithout a contrast agent is not conclusive in the fol-lowing applications: (i) At rest, when the quality ofimages obtained without contrast agent makes the visu-alization of at least 5 contiguous segments of a totalof 17 not conclusive, and, (ii) during stress when thequality of the images obtained without contrast agentmakes the visualization of at least 2 contiguous seg-ments of a total of 17 not conclusive. The segmentationof the left ventricle is based on the recommendationsof the American Heart Association. The examinationswill be conducted by devices with software for har-monic imaging with a low mechanical index less thanor equal to 0.3, allowing the mandatory digitalarchiving of images before and after contrast. Evidenceshowing that the above conditions are met, must beheld available to the insurer by the medical provider.For echocardiography, the documents would be sub-jected to peer review.Although, UCA still account for a small proportionof diagnostic examinations
Biophysical and Motion Features Extraction for an Effective Home-Based Rehabilitation

In this paper, we describe ReMoVES (REmote MOnitoring Validation Engineering System) which is a newly developed platform for motion rehabilitation through serious-games and biophysical sensors. The main features of the system are highlighted: motion tracking capabilities are disclosed and compared with other solutions; the emotional state of the patient is evaluated with heart rate measurements and electrodermal activity monitoring during the execution of the functional exercises planned by the therapist. Preliminary results about the extraction of significant features from motion and biophysical data will be discussed: the personal rehabilitation program is meant to be performed at home by the patient himself while ReMoVES platform should deliver effective reports to the therapist about the training performance.
Evaluación del debido proceso como factor determinante de la legitimidad de la regulación contable colombiana: una aproximación

El presente documento propone un analisis de la legitimidad de la regulacion contable en Colombia, a partir del concepto de “debido proceso”, usando las categorias analiticas propuestas por Suchman y otros autores sobre legitimidad. El documento concluye que existe un deficit de legitimidad en el ordenamiento regulatorio contable en Colombia, en la medida en que los reguladores mismos incumplen el debido procesos en la emision de normas de contabilidad, en el marco de la convergencia decretada por la Ley 1314 de 2009, con consecuencias sobre la capacidad del ente regulador –Consejo Tecnico de la Contaduria Publica– y la calidad de la regulacion propiamente dicha.
Electroacupuncture at He-Mu points reduces P2X4 receptor expression in visceral hypersensitivity

Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats. Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome. Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X4 receptor immureactivity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X4 receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord.
A Unique Case of Increased 18F-FDG Metabolic Activity in the Soft Tissues of the Bilateral Upper Thighs Due to Immunizations in a Pediatric Patient

A case of a 7-month-old white female who was referred for 18F-fluorodeoxyglucose (FDG) Positron emission tomography/computed tomography (PET/CT) initial evaluation of a lytic skull lesion with presumed diagnosis of Langerhans cell histiocytosis is described. Incidentally, she was found to have hypermetabolic nodules in the soft tissues of her anterior thighs.
Differential Binding of the NFE3 and CP1/NFY Transcription Factors to the Human γ- and ε-Globin CCAAT Boxes (*)

Naturally occurring nondeletional mutations affecting the distal CCAAT box of the human γ-globin gene promoter result in hereditary persistence of fetal hemoglobin in adult life. Although the distal CCAAT box is the target of several factors, including CP1/NFY, CDP, GATA-1 and NFE3, only NFE3 binding activity is consistently sensitive to well characterized mutations in this region such as G−117 → A, C−114 → T, and Δ13 hereditary persistence of fetal hemoglobin. We extensively characterized the binding specificities of NFE3 and demonstrated that NFE3 has unique properties with respect to other CCAAT box-binding proteins. Affinity-purified NFE3 from erythroid K562 cells binds the distal but not the proximal human γ-globin CCAAT box, the single CCAAT box of the human ϵ-globin promoter, and the proximal CCAAT box of the evolutionarily related Galago crassicaudatus γ-globin gene. Within the ϵ-globin CCAAT box, NFE3 represents the major and almost exclusive binding activity. Disruption of such a binding site essentially inactivates the ϵ-globin promoter, suggesting that NFE3 plays an important role in the embryonic expression of this gene.
Evidence for the Involvement of the Na+-K+-ATPase in the Mechanism of Axonal Protein and Nucleoside Transport

Abstract [3H] Proline and [3H] uridine were injected into both eyes of the goldfish. 1 h before and after this injection 3 × 10-6 м ouabain was administrated unilaterally to the retina. 8 h and 24 h after tracer injection the radioactivity in the retina, optic nerve and tectum was measured. It is suggested that the inhibition of the neuronal Na+-K+-ATPase inside the retina is responsible for the reduction of the labelled material transported into the optic nerve.
Spectrum Sensing for Wireless Microphone Signals Using Multiple Antennas

Spectrum sensors for cognitive radio are expected to deploy multiple antennas to overcome the noise uncertainty problem and to minimize the effects of small-scale fading. Despite the requirement that these sensors must detect wireless microphone (WM) signals, several studies have focused either on general-purpose multiantenna detectors or on single-antenna WM detectors. We exploit the spatial structure and particular properties of WM waveforms to derive four multiantenna detectors for WM signals with different performance/complexity tradeoffs. These detectors are based on the generalized likelihood ratio (GLR) test, which is derived under several signal models exploiting either that the bandwidth of a WM signal never exceeds 200 kHz, that these signals have a constant magnitude (CM), or both. The proposed detectors do not require synchronization with the WM signal and are robust to the noise uncertainty problem and to small-scale fading. Using the simulation guidelines from the IEEE 802.22 standard, the novel multiantenna WM detectors are shown to outperform previous schemes, thus demonstrating the advantages of exploiting spatial correlation along with the WM signal structure.
Serotype diversity as a drawback in the surveillance of Shiga toxin-producing Escherichia coli infections in Brazil.

Shiga toxin-producing Escherichia coli (STEC) strains have emerged worldwide as an important cause of gastrointestinal diseases and complications in humans (Nataro & Kaper, 1998). Diarrhoea and haemolytic uraemic syndrome (HUS) associated with STEC have also been reported in patients with acquired immunodeficiency syndrome (AIDS) (Garcia Lara et al., 2000; Suthienkul et al., 2001; Pouessel et al., 2004). Although O157 : H7 is the prominent STEC serotype, in the last decade many non-O157 STEC strains were also reported in diarrhoea-associated illnesses and complications. Some outbreaks caused by non-O157 STEC strains have already been reported, although in many countries these organisms are more frequently associated with sporadic cases of diarrhoea, haemorrhagic colitis and HUS (Brooks et al., 2004; Pradel et al., 2000).