Miracle-dz/UniFAR-FTUs huggingface dataset:
Fine Tuning of Electrical Transport and Dielectric Properties of Epoxy/Carbon Nanotubes Composites via Magnesium Oxide Additives

The dielectric properties of epoxy/MWCNT (multi-walled carbon nanotubes)/MgO hybrid composites with a fixed MWCNT amount of 0.12 vol.% (0.2 wt.%) and varying MgO concentrations up to 3 vol.% were investigated in broad frequency (20–40 GHz) and temperature (20–500 K) ranges. The composites with up to 2 vol.% MgO nanoparticles concentration showed a significant increase of DC conductivity in relation to their non MgO-containing counterparts. The optimal content of MgO was found, i.e., 0.46 vol.%, which gave up to 2.5 orders of magnitude larger DC conductivity than those of the samples prepared without MgO additives. Using various amounts of MgO, it is possible to predictably vary the broadband electromagnetic properties of the composites, even entirely eliminating the electrical percolation. Electrical transport at different temperatures can be substantially controlled by the addition of given amounts of MgO. The broadband properties are discussed in terms of the distribution of relaxation times, which are proven to be an effective, noninvasive, and simple tool for checking composite fabrication issues, such as the distribution of MWCNT aggregates within the epoxy matrix.
Assessment of Radio-Induced Damage in Endothelial Cells Irradiated with 40 kVp, 220 kVp, and 4 MV X-rays by Means of Micro and Nanodosimetric Calculations

The objective of this work was to study the differences in terms of early biological effects that might exist between different X-rays energies by using a mechanistic approach. To this end, radiobiological experiments exposing cell monolayers to three X-ray energies were performed in order to assess the yields of early DNA damage, in particular of double-strand breaks (DSBs). The simulation of these irradiations was set in order to understand the differences in the obtained experimental results. Hence, simulated results in terms of microdosimetric spectra and early DSB induction were analyzed and compared to the experimental data. Human umbilical vein endothelial cells (HUVECs) were irradiated with 40, 220 kVp, and 4 MV X-rays. The Geant4 Monte Carlo simulation toolkit and its extension Geant4-DNA were used for the simulations. Microdosimetric calculations aiming to determine possible differences in the variability of the energy absorbed by the irradiated cell population for those photon spectra were performed on 10,000 endothelial cell nuclei representing a cell monolayer. Nanodosimetric simulations were also carried out using a computation chain that allowed the simulation of physical, physico-chemical, and chemical stages on a single realistic endothelial cell nucleus model including both heterochromatin and euchromatin. DNA damage was scored in terms of yields of prompt DSBs per Gray (Gy) and per giga (109) base pair (Gbp) and DSB complexity was derived in order to be compared to experimental data expressed as numbers of histone variant H2AX (γ-H2AX) foci per cell. The calculated microdosimetric spread in the irradiated cell population was similar when comparing between 40 and 220 kVp X-rays and higher when comparing with 4 MV X-rays. Simulated yields of induced DSB/Gy/Gbp were found to be equivalent to those for 40 and 220 kVp but larger than those for 4 MV, resulting in a relative biological effectiveness (RBE) of 1.3. Additionally, DSB complexity was similar between the considered photon spectra. Simulated results were in good agreement with experimental data obtained by IRSN (Institut de radioprotection et de sûreté nucléaire) radiobiologists. Despite differences in photon energy, few differences were observed when comparing between 40 and 220 kVp X-rays in microdosimetric and nanodosimetric calculations. Nevertheless, variations were observed when comparing between 40/220 kVp and 4 MV X-rays. Thanks to the simulation results, these variations were able to be explained by the differences in the production of secondary electrons with energies below 10 keV.
Greatwall-Endosulfine: A Molecular Switch that Regulates PP2A/B55 Protein Phosphatase Activity in Dividing and Quiescent Cells

During the cell cycle, hundreds of proteins become phosphorylated and dephosphorylated, indicating that protein kinases and protein phosphatases play a central role in its regulation. It has been widely recognized that oscillation in cyclin-dependent kinase (CDK) activity promotes DNA replication, during S-phase, and chromosome segregation, during mitosis. Each CDK substrate phosphorylation status is defined by the balance between CDKs and CDK-counteracting phosphatases. In fission yeast and animal cells, PP2A/B55 is the main protein phosphatase that counteracts CDK activity. PP2A/B55 plays a key role in mitotic entry and mitotic exit, and it is regulated by the Greatwall-Endosulfine (ENSA) molecular switch that inactivates PP2A/B55 at the onset of mitosis, allowing maximal CDK activity at metaphase. The Greatwall-ENSA-PP2A/B55 pathway is highly conserved from yeast to animal cells. In yeasts, Greatwall is negatively regulated by nutrients through TORC1 and S6 kinase, and couples cell growth, regulated by TORC1, to cell cycle progression, driven by CDK activity. In animal cells, Greatwall is phosphorylated and activated by Cdk1 at G2/M, generating a bistable molecular switch that results in full activation of Cdk1/CyclinB. Here we review the current knowledge of the Greatwall-ENSA-PP2A/B55 pathway and discuss its role in cell cycle progression and as an integrator of nutritional cues.
Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype

The kinase AKT2 (PKB) is an important mediator of insulin signaling, for which loss-of-function knockout (KO) mutants lead to early onset diabetes mellitus, and dominant active mutations lead to early development of obesity and endothelial cell (EC) dysfunction. To model EC dysfunction, we used edited human pluripotent stem cells (hPSCs) that carried either a homozygous deletion of AKT2 (AKT2 KO) or a dominant active mutation (AKT2 E17K), which, along with the parental wild type (WT), were differentiated into ECs. Profiling of EC lines indicated an increase in proinflammatory and a reduction in anti-inflammatory fatty acids, an increase in inflammatory chemokines in cell supernatants, increased expression of proinflammatory genes, and increased binding to the EC monolayer in a functional leukocyte adhesion assay for both AKT2 KO and AKT2 E17K. Collectively, these findings suggest that vascular endothelial inflammation that results from dysregulated insulin signaling (homeostasis) may contribute to coronary artery disease, and that either downregulation or upregulation of the insulin pathway may lead to inflammation of endothelial cells. This suggests that the standard of care for patients must be expanded from control of metabolic parameters to include control of inflammation, such that endothelial dysfunction and cardiovascular disorders can ultimately be prevented.
Influence of Biologically Oriented Preparation Technique on Peri-Implant Tissues; Prospective Randomized Clinical Trial with Three-Year Follow-Up. Part I: Hard Tissues

Purpose: The objective of this prospective randomized clinical trial (RCT) was to analyze and compare the clinical behavior of three types of prosthesis supported by single implants in the posterior region after three years functional loading. Materials and Methods: Seventy-five implants were divided into three groups according to the type of prosthetic restoration: screw-retained crown (Group GS); cemented crown without finishing line (biologically oriented preparation technique) (Group GBOPT); and conventional cemented crown with finishing line (Group GCC). The clinical behavior of each restoration type was analyzed after 3 years functional loading by analyzing radiographic peri-implant bone loss. Results: GBOPT obtained the least bone loss (p < 0.01) in comparison with GS and GCC. Conclusions: Bone loss around implants is related to the type of prosthetic restoration it supports, whereby cemented BOPT crowns present less bone loss.
Prevalence and Sources of Second-Hand Smoking Exposure among Non-Smoking Pregnant Women in an Urban Setting of Vietnam

Exposure to second-hand smoke (SHS) among non-smoking pregnant women can lead to adverse maternal and fetal outcomes. A cross-sectional study was performed from July to August 2016 among 432 pregnant women at Bach Mai Hospital, Hanoi, Vietnam, to assess the prevalence and sources of SHS exposure among non-smoking pregnant women. Socio-economic characteristics and information regarding SHS exposure of participants were collected. Multivariable logistic regression was employed to identify associated factors. Overall, 92.6% and 64.5% of pregnant women were exposed to SHS in their lifetime and in the last 30 days, respectively. Cafeterias and restaurants had the highest proportion of pregnant women exposed to SHS. Those who reported that “smoking is allowed at home” (OR = 3.18; 95%CI = 1.97–5.13); going to working place (OR = 1.86; 95%CI = 1.08–3.19), going to state authority offices (OR = 1.98; 95%CI = 1.15–3.41), and cafeterias (OR = 1.96; 95%CI = 1.22–3.16) had the highest risk of SHS exposure in the last 30 days. We have found a high proportion of SHS exposure among non-smoking pregnant women in Vietnam. This comes from a multitude of sources, including homes, workplaces, cafeterias, and restaurants. The data emphasises the need for further intervention to address this health issue.
Mouse t-complex protein 11 is important for progressive motility in sperm†

Abstract The t-complex is defined as naturally occurring variants of the proximal third of mouse chromosome 17 and has been studied by mouse geneticists for decades. This region contains many genes involved in processes from embryogenesis to sperm function. One such gene, t-complex protein 11 (Tcp11), was identified as a testis-specific gene whose protein is present in elongating spermatids. Later work on Tcp11 localized TCP11 to the sperm surface and acrosome cap and implicated TCP11 as important for sperm capacitation through the cyclic AMP/Protein Kinase A pathway. Here, we show that TCP11 is cytoplasmically localized to elongating spermatids and absent from sperm. In the absence of Tcp11, male mice have severely reduced fertility due to a significant decrease in progressively motile sperm; however, Tcp11-null sperm continues to undergo tyrosine phosphorylation, a hallmark of capacitation. Interestingly, null sperm displays reduced PKA activity, consistent with previous reports. Our work demonstrates that TCP11 functions in elongated spermatids to confer proper motility in mature sperm. Summary sentence T-complex protein 11, Tcp11, encodes a cytoplasmic protein expressed in the late stages of spermiogenesis that is important for sperm motility.
The Replication Crisis as Market Failure

This paper begins with the observation that the constrained maximisation central to model estimation and hypothesis testing may be interpreted as a kind of profit maximisation. The output of estimation is a model that maximises some measure of model fit, subject to costs that may be interpreted as the shadow price of constraints imposed on the model. The replication crisis may be regarded as a market failure in which the price of “significant” results is lower than would be socially optimal.
Star cluster formation caught in the act at z = 6 3619

We report on a superdense star-forming region with an effective radius (Re) smaller than 13 pc identified at z = 6.143 and showing a star formation rate density SFR ∼ 1000 M yr−1 kpc−2 (or conservatively >300 M yr−1 kpc−2). Such a dense region is detected with S/N 40 hosted by a dwarf extending over 440 pc, dubbed D1. D1 is magnified by a factor 17.4(±5.0) behind the Hubble Frontier Field galaxy cluster MACS J0416 and elongated tangentially by a factor 13.2 ± 4.0 (including the systematic errors). The lens model accurately reproduces the positions of the confirmed multiple images with a rms of 0.35 arcsec. D1 is part of an interacting star-forming complex extending over 800 pc. The SED-fitting, the very blue ultraviolet slope (β −2.5, Fλ ∼ λ), and the prominent Lyα emission of the stellar complex imply that very young (<10−100 Myr), moderately dust-attenuated (E(B − V) < 0.15) stellar populations are present and organized in dense subcomponents. We argue that D1 (with a stellar mass of 2 × 107 M ) might contain a young massive star cluster of M 106 M and MUV −15.6 (or mUV = 31.1), confined within a region of 13 pc, and not dissimilar from some local super star clusters (SSCs). The ultraviolet appearance of D1 is also consistent with a simulated local dwarf hosting an SSC placed at z = 6 and lensed back to the observer. This compact system fits into some popular globular cluster formation scenarios. We show that future high spatial resolution imaging (e.g. E-ELT/MAORY-MICADO and VLT/MAVIS) will allow us to spatially resolve light profiles of 2–8 pc.
RENEWAL PARADIGM OF THE LDII COMMUNITY

This article attempts to explore the dynamics of the Lembaga Dakwah Islam Indonesia (LDII) or Indonesian Islamic Da’wah Institution community in Kediri of East Java, Indonesia in maintaining its existence, transforming and seeing the processes, patterns and strategies that developed by the LDII. The article elaborates how social actors of the LDII carry out social practices continuously, so that LDII can continue to survive, develop, and reform the doctrine and religious identity paradigm and its organizational identity thus being accepted by people in the region. The role of the actors as the agent in changing the character of the movement is discussed in this work. They have made strategies including building closeness to the authorities, building attitudes of openness, changing the image of the organization, strengthening identity, establishing dialogue and public cooperation with the Indonesian Ulema Council (MUI – Majelis Ulama Indonesia) that positioning LDII as a heretical and splinter organization, and establishing cooperation with Religious Community Organizations (Ormas) that are considered mainstream, such as NU (Nahdatul Ulama) and Muhammadiyah. This work attempts to provide materials and considerations in dealing with the issue raising between the flow of splinters and established groups.
NELLCOR PULSE OXIMETRY MOTION TESTING

The Nellcor N-600x pulse oximeter from Medtronic has shown motion tolerance and compliance with recently introduced specifications and recommendations of the International Standards Organization and the United States Food and Drug Administration. Novel use of monitoring equipment and metrics has provided a chain of evidence that demonstrates compliance to the test protocol and industry recommendations.
The Theoretical Legacies of Cultural Materialism and Marvin Harris , In Studying Societies and Cultures : Marvin Harris ’ s Cultural Materialism and Its Legacy .

Cultural materialism has many virtues, foremost amo ng them its explicit appeal to the epistemology of science, but the paradigm is fundamentally flawed i n ways that will severely limit its usefulness as a guideline for future anthropological research and analysis. W hen anthropology finally emerges as a mature scient ific discipline (one devoted exclusively to discovering facts and generating theories in the genuine scientific senses of the terms), the theoretical principles of cultur al materialism will not play a major role. On the o ther hand, Marvin Harris was a proponent of several essential propositions that will serve as a blueprint for the construction of a mature science of anthropology. T he legacy of cultural materialism will be distinct from the legacy of Marvin Harris.
30 Jahre Lärmschutz am Arbeitsplatz – erfolgreiche Prävention ?

I n Deutschland wird der Anteil der Arbeitnehmer, die oberhalb der Auslöseschwelle von 85 dB(A) Tageslärmexpositionspegel exponiert sind, von Experten auf 7 bis 11 % geschätzt. Das heißt, in Deutschland sind zwischen 3 und 4,5 Mio. Arbeitnehmer Schalldruckpegeln von über 85 dB(A) am Arbeitsplatz ausgesetzt. Bei den anerkannten Berufskrankheiten stand die Lärmschwerhörigkeit 2005 mit 39 % an erster Stelle, gefolgt von der Asbestose mit 15 %. In Bild 1 zeigt sich für die Lärmschwerhörigkeit ein rapider Anstieg der Anzeigezahlen von 1970, die sich bis 1977 auf über 20 000 etwa verzehnfacht hatten [3]. Anschließend setzte eine ebenso starke Abnahme der jährlichen Fallzahl bis auf rund 8 200 im Jahr 1984 ein. Danach zeigte sich ein unregelmäßiger, insgesamt jedoch ansteigender Verlauf bis auf gut 13 500 Verdachtsanzeigen im Jahre 1993. Seither weist die Anzeigenzahl wieder einen fallenden Trend auf. Die seit 1978 verfügbaren Zahlen der als Lärmschwerhörigkeit anerkannten Berufskrankheiten liegen deutlich unter denen der Anzeigen auf Verdacht. Sie verlaufen jedoch annähernd parallel. Ein deutlicher Zuwachs war von 1992 auf 1993 zu verzeichnen (von 3 962 auf 6 266 Fälle), der vorwiegend auf die neu eingeführte Anerkennung von Versicherungsfällen auch ohne Eintritt des Leistungsfalls zurückzuführen sein dürfte. Der Versicherungsfall ist bereits bei Vorliegen eines regelwidrigen Körperoder Geisteszustandes gegeben, auch wenn weder eine behandlungsbedürftige Krankheit im Sinne der Krankenversicherung noch eine renten berechtigende Minderung der Erwerbsfähigkeit (als Beispiel für einen Leistungsfall) vorliegt. Der Verlauf der Zahl der neuen Renten folgte bis 1985 ungefähr dem Verlauf der Anzeigen bzw. der Anerkennungen. Seither bewegte er sich bis 1991 bei etwa 900 bis 1 200 Fällen jährlich. Danach setzte ein Anstieg bis auf 1 425 Fälle im Jahr 1996 ein, gefolgt von einem deutlichen Rückgang bis auf 486 Fälle im Jahr 2005. Es scheint, dass mit Einführung der flächendeckenden Gehörvorsorgeuntersuchungen [4] und weiterer Lärmschutzmaßnahmen in den 1970er Jahren bis etwa 1985 alle Altfälle von beruf licher Lärmschwerhörigkeit erfasst wurden. Mit „Altfällen“ sind diejenigen Fälle gemeint, die schon in den 1950er und 1960er Jahren erfasst worden wären, wäre eine flächendeckende Gehörvorsorge vorhanden gewesen. Das heißt, ab etwa 1985 kann man davon ausgehen, dass nur neue Fälle beruflicher Lärmschwerhörigkeit in den Berufskrankheitenstatistiken (BK 2301) dokumentiert wurden. In den letzten Jahrzehnten unternahmen Arbeitgeber, Arbeitnehmer, Sicherheitsfachkräfte, Betriebsärzte, Berufsgenossenschaften und andere Unfallversicherungsträger große Anstrengungen im Bereich des Lärmschutzes am Arbeitsplatz. Aber erst seit 1997 ist ein leichter Rückgang der neuen BK2301-Renten zu verzeichnen. Kann dieser Rückgang als Erfolg der Lärmschutzmaßnahmen an den Arbeitsplätzen in den letzten 30 Jahren angesehen werden?
Personality Characteristics, Motivations and Usage Patterns of Social Networking Sites among University Students

Sosyal ag siteleri (SAS) bu gunlerde tum yas gruplarinda oldukca populer hale gelmistir ve ozellikle genc nufusun da ilgisini cekmektedir. Bu ortamlar kullaniciya kamuya acik bir profil olusturma imkanini ve diger kullanicilarla etkilesim olanagini saglar. Bir SAS sosyal bir internet sayfasi olabilecegi gibi sosyal ag sitesi uzerinden edinilmis bir sitede olabilir. Bu calisma sosyal ag sitelerine bagli kullanici profilllerinin tanimlamalarini incelemek icin tasarlanmistir. Calismanin amaci ise universite ogrencilerinin sosyal ag sitelerini kullanmaya iten faktorleri daha iyi anlamak ve bu konuda daha kapsamla bilgi sunabilmektedir. Calisma kapsaminda ozellikle cinsiyet, motivasyon faktorleri ve kisilik degiskenlerinin SAS bagimliligi uzerindeki etkisi incelenmistir. Calismani bagimsiz degiskenleri cinsiyet, kisilik ozellikleri ve SAS kullanimina yonelik kisisel sebepler iken bagimli degisken SAS kullanim sikligi olarak belirlenmistir. Calisma sonucunda kisilik ozellikleri ile SAS bagimliligi arasinda anlamli bir iliski bulunmamakla beraber cinsiyet farkliliginin SAS bagimligi uzerinde kismi bir etkisi olabilecegi saptanmistir. Motivasyon faktorlerinden ise sadece rahatlatici ve eglence motivasyonlarinin SNS bagimliligini yordadigi bulunmustur.
Alternative Measures of the Cost of Equity Capital for the Federal Reserve Banks ’ Payments Services : Technical Supplement to the 2004 PSAF Review

In this technical supplement, we provide additional information on the methods used to generate alternative measures of the Federal Reserve Banks’ cost of equity capital (COE) examined within the context of the 2004 PSAF Review. Specifically, we discuss: the construction of a more focused peer group of bank holding companies; our ex-ante model selection criteria; the various CAPM model specifications we examined and their empirical results; and incorporating BHC leverage ratios into the analysis.
Exploiting Symmetry in Elemental Computation and Assembly Stage of GPU-Accelerated FEA

Finite element analysis (FEA) is one of the most popular numerical methods for solutions of boundary value problems in partial differential equations (PDEs). Owing to the computational load of handling fine meshes and complex geometries in many real-world problems coupled with the data-parallel and throughput-intensive nature of FEA computation, it is considered a highly suitable candidate for Graphics processing units (GPU) based acceleration. This work aims to accelerate the elemental stiffness calculation and assembly stages of FEA on a single GPU by exploiting the symmetric nature of the elemental and global stiffness matrix. The key idea of the implementation is to design GPU kernels that calculate and assemble only the lower triangular part of the local stiffness matrix into the global stiffness matrix. This leads to (a) reduced FLOP count and (b) reduced memory storage and access, which, in turn results in an overall reduced execution time. The elemental stiffness matrix is computed by assigning each GPU thread to one entry of the elemental stiffness matrix. The assembly stage is performed in two steps for computing the indices and values of the global stiffness matrix. For handling the race condition in assembly, mesh coloring and atomics-based approaches are implemented. The results from the proposed implementation is compared to a standard GPUbased version of the implementation that computes and assembles the complete elemental stiffness matrices. Hexahedral meshes with up to three million nodes are tested for the performance analysis. The proposed implementation is found to be approximately twice as fast as the standard implementation for both elemental calculation and assembly stages.
GAMIFICATION AND MOTIVATION: A PRELIMINARY SURVEY

Nowadays, computer/video games are increasingly becoming part of the daily activities of students of all ages. Computer/video games have also been shown to support student motivation and learning. In order to effectively gamify learning, educators need to understand the related aspects regarding games, motivational psychology and also pedagogy. This paper discusses a number of different approaches employed in gamification in terms of motivational psychology and pedagogy. The first section introduces on motivational factors that affect learning and also behavioral change among learners. The second section elaborates on a case study done to investigate the students’ interest and opinions towards computer/video game. The final section of the paper concludes with a paragraph that proposed pedagogical strategies when implementing gamification as an education tool.