Miracle-dz/UniFAR-FTUs huggingface dataset:
Oxidative Modifications of Parkin Underlie its Selective Neuroprotection in Adult Human Brain

The mechanisms by which Parkinson disease-linked parkin confers neuroprotection of human dopamine cells remain elusive. We hypothesized that its cysteines mediate multiple anti-oxidant effects in the midbrain. By studying >60 control specimens, we found that in adult human brain - but not in skeletal muscle- parkin is mostly aggregated and insoluble due to oxidative modifications, such as at C253. In vitro, parkin’s oxidation directly reduces hydrogen peroxide (H2O2) to water. In parkin-deficient human brain, H2O2 concentrations are elevated. In dopamine toxicity studies, wild-type parkin -but not disease-associated mutants-prevents neural death by lowering H2O2 and sequestering radicals within insoluble aggregates. Parkin conjugates dopamine metabolites at the human-specific residue C95 and augments melanin formation in vitro. Using epitope-mapped antibodies, we found that in adult Substantia nigra neurons parkin localizes to neuromelanin within LAMP-3/CD63-positive lysosomes. We conclude that parkin’s own oxidation, previously considered a loss-of-function event, underlies three neuroprotective effects in adult midbrain: its cysteines participate in H2O2 reduction, dopamine radical conjugation and the formation of neuromelanin.
Association analysis between genes involved in the inflammatory response, mean plasma levels and variability of CRP in post myocardial infarction survivors

There is convincing evidence that atherosclerosis has typical features of an inflammatory disease. Local inflammation in the artery wall is accompanied by a systemic low-grade inflammatory response, which can be measured by C-reactive protein (CRP). This work investigated the influence of genetic variation in thirteen innate immunity genes on CRP plasma concentrations in myocardial infarction survivors and assessed the genetic impact of the within-subject variability. Therefore, CRP was measured repeatedly and 114 polymorphisms were genotyped and statistically analyzed. The obtained associations contribute to the understanding of the genetics of CRP in a population at high risk, especially in terms of gene-environment interactions.
The Efficacy of Palifermin on Oral Mucositis and acute GVHD after Hematopoietic Stem Cell Transplantation in Hematologic Malignancy Patients: A Systematic Review and Meta-analysis study

Oral mucositis (OM) is one of the most common side effects after hematopoietic stem cell transplantation (HSCT) and palifermin is used for prophylactic use to prevent OM. We conducted a meta-analysis study that evaluates the efficacy of palifermin on OM after HSCT in hematologic malignancy patients. Databases of PubMed/Medline, Web of Science and Cochrane Library for English-language publications were searched for finding the relevant studies. The RevMan 5.3 software with random-effects models (odds ratio (ORs) and 95% confidence intervals (CIs)) was used for to estimate of the efficacy of palifermin in palifermin group compared with control group. Begg's and Egger's tests were used for assessment of bias between the studies. Ten studies were included in the meta-analysis study. The results of the meta-analyses showed that there were significant differences in OM (grade 1-4) [odds ratio (OR) = 0.17; 95%CI= 0.10,0.29; p <0.00001], OM (grade 2-4) [OR= 0.11; 95%CI= 0.05,0.24; p <0.00001], OM (grade 3-4) [OR= 0.22; 95%CI= 0.15,0.33; p <0.00001], after auto-HSCT for OM (grade 1-4) [OR= 0.13; 95%CI= 0.04, 0.35; p <0.0001], OM (grade 2-4) [OR= 0.03; 95%CI= 0.00, 0.21; p =0.0006] or OM (grade 3-4) [OR= 0.25; 95%CI= 0.13, 0.48; p <0.0001], after allo-HSCT for OM (grade 1-4) [OR= 0.23; 95%CI= 0.11, 0.51; p =0.0002], OM (grade 2-4) [OR= 0.14; 95%CI= 0.03, 0.74; p =0.012] or OM (grade 3-4) [OR= 0.19; 95%CI= 0.08, 0.46; p =0.0002] and fever [OR=0.51; 95%CI=0.29, 0.87; p = 0.01], but there were no significant differences in acute graft versus host disease (aGVHD) grades, infection and blood stream infection between two groups. The meta-analysis showed that palifermin was associated with reductions in the incidence and severity of OM and also was effective and safe on OM after allo- or auto-HSCT, but did not seem to effect on the incidence and severity of aGVHD.
Novel wearable cooling device for early initiation of targeted temperature management in the Emergency Department

Background: Targeted temperature management (TTM) is an important component of post-cardiac arrest care. Studies have suggested that cooling is associated with better outcomes. The aim of this study was to evaluate the cooling efficacy of a protocol including a novel cooling device in the Emergency Department. Methods: This was a single-center, pre-post cohort study of post-cardiac arrest patients with return of spontaneous circulation (ROSC), for whom TTM was initiated at a tertiary hospital between April 2010 and December 2017. A surface cooling device which uses a graphite cooling material in an insulating suit was introduced in July 2015. The target temperature was 34.0 °C with TTM continued in the ICUs. The primary outcome was time from ROSC to target temperature (TT). Results: Of 124 patients included, 40 were in the intervention period and 84 in the control period. Time from ROSC to TT was significantly lower in the intervention period at 119 [interquartile range (IQR), 65–250] minutes versus 482 (IQR, 356–596) minutes (P Conclusions: Use of a novel cooling device in the ED resulted in a shorter time to target temperature. As it is reusable and does not require a power source, it has potential to be an affordable solution for pre- hospital and transport cooling.
Subjective-existential interpretation of ideas about the educational environment of students in a situation of prolonged academic failure

The article analyzes the features of ideas about the educational environment of students who have been in a situation of educational failure for a long period of time. Analysis and interpretation of the results are conducted on the basis of a subjective-existential approach to personality. The main position of the given approach assumes the presence of opportunities and basic needs of the person for the demonstration (self-fulfillment) of himself in various spaces of being. Blocking these opportunities (objective or subjectively understood) deprives a person of subjective activity. The article poses and remains open the question of personal dispositions of situations of failure. Variants of ideas about the forming environment of underachieving (according to objective parameters) students are viewed. The study defined the relationship between the leading trends of the environment (personality data in representations) and real achievements of the personality in these specific situational conditions. The levelling of activity as an environmental parameter in the representations of underachieving students is shown. Being space is not interpreted by the person as providing an opportunity to be active at low objective indicators of the success of activities implemented in this environment.
Ad Hoc On-demand Distance Vector Inherent Techniques Comparison for Detecting and Eliminating the Black Hole Attack Nodes in Mobile Ad Hoc Network

It is important to connect wirelessly a group of moving mobile nodes together in a static or dynamic form, to transfer digital data between them, this form known as a mobile ad hoc network. This private network can be used in different essential situations where it depends on each connected mobile node to deliver and pass the data between them, without any fixed access point or router. Unfortunately, there are different types of attacks that can affect these nodes, and steal or corrupt the data inside, one of these attacks called the black hole attack. In this paper, a compared study will be done between two major innovative techniques derived from the ad hoc on-demand distance vector routing protocol to avoid the black hole attack; the paper will compare the two techniques in delay, throughput and packet dropping efficacy.
CaptureCompendium: a comprehensive toolkit for 3C analysis

DNA folding within nuclei is a highly ordered process, with implications for gene regulation and development. An array of chromosome conformation capture (3C) methods have been developed to investigate how DNA is packaged within nuclei and to interrogate specific interactions. While these methods use different approaches to examine target loci (many-versus-all) or the entire genome (all-versus-all), they all rely on the core principle of endonuclease digestion and proximity-based ligation to re-arrange genomic order to reflect the three-dimensional nuclear conformation. This sequence reorganization creates novel chimeric DNA fragments which require specialist bioinformatic tools to analyze and visualize. Despite this need for specialist bioinformatic skills, the core biological importance of genome folding has seen widespread methodological uptake. To service the needs of experimentalists using the many-versus-all Capture-C family of methods we have developed CaptureCompendium; a toolkit of software to simplify the design, analysis and presentation of 3C experiments.
Tradition and Transformation in a Chinese Family Business

List of figures List of tables Acknowledgements Notes Part I 1 Introduction 2 Politics, economy, and society of post-war Hong Kong 3 A life history of Fong 4 To produce or to die: the development of Fong's manufacturing business 5 Beyond manufacturing: the development of Fong's showroom business 6 From a manufacturer to a brand: the development of Fong's retail business Part II 7 Jan cing mei management 8 The crises 9 The transformers and the transformation 10 The eternal return of the Chinese boss 11 Conclusion References Glossary Index
İngilizce Öğretiminde İşbirlikli Öğrenme Destekli Eğitsel Eğlenceli Etkinliklerin Öğrencilerin Motivasyonlarına Etkisi

Bu arastirmanin amaci, Ingilizce ogretiminde isbirlikli ogrenme destekli egitsel eglenceli etkinliklerin ogrencilerin motivasyonlarina etkisini belirlemektir. Bu arastirma Elazig Namik Kemal Ilkogretim okulunda bulunan 105 besinci sinif ogrencisi icerisinden yansizlik olcutune gore secilen toplam 68 ogrenci uzerinde yurutulmustur. Arastirmada on test-son test kontrol gruplu deneysel desen uygulanmistir. Veriler Kara (2008) tarafindan Turkceye uyarlanan “Egitimde Motivasyon Olcegi (EMO)” ile elde edilmistir. Verilerin istatistiksel analizleri sonucunda isbirlikli ogrenme destekli egitsel eglenceli etkinliklerin ogrencilerin motivasyon duzeyleri uzerinde anlamli etkiye sahip oldugu gorulmustur.
MANAGEMENT OF LARGE PERIAPICAL LESIONS BY NON SURGICAL ENDODONTIC APPROACH - TWO CASE REPORTS

Aim: To report two cases of conservative nonsurgical management of periapical lesion of odontogenic cause. Background: Small periapical lesions of endodontic origin usually heal by conventional endodontic therapy alone. Earlier larger periapical lesions are treated by surgical intervention for complete cure, but nowadays conservative nonsurgical management of such lesions are preferred as it eliminates the possible complications of surgery and has wider patient compliance and acceptance. Case description: In the first case, a periapical cystic lesion associated with mandibular left central incisor and in the second case, large periapical lesion (> 4mm) in relation to right maxillary lateral incisor and canine were treated conservatively by conventional endodontic therapy employing calcium hydroxide iodoform paste as intracanal medicament. Clinical significance: These treatments were successful as evidenced by relief of symptoms and radiographic evaluation. Conclusion: Large periapical lesions can resolve by nonsurgical endodontic therapy employing calcium hydroxide intracanal inter appointment medicament. Keywords: Periapical lesions, Non surgical management, Calcium hydroxide.
A rare case of primary umbilical endometriosis in a nulliparous female confirmed on imaging and histopathology: Case report

Endometriosis is a common gynaecological condition, the pelvis being the most common site. Extrapelvic sites including intestinal tract, urinary tract, omentum, thorax, surgical scars and umbilicus are less common sites and are difficult to diagnose. Majority of extrapelvic cases occur at surgical scar sites. Occurrence of umbilical endometriosis in a patient without any previous surgical history is a very rare condition. So, we are going to report the case of a primary umbilical endometriosis in a 40 years old nulliparous female presented with complaints of pain abdomen associated with bleeding per vaginum and cyclical bleeding from umbilical region since 2 months.This paper summarises the topic of umbilical endometriosis and discusses the radiological and clinical implication of this unusual condition.
Enlightenment Teaching of Engineering Cognition for Junior High School Students Based on Linear Function

The earlier the enlightenment teaching of engineering cognition is conducted, the better for fostering engineering talents. In China, the knowledge about linear function or univariate equation is taught to the students in their junior high school period. This should be a precious opportunity for enlightenment teaching of engineering based on application of linear function in routine life. In the present investigation, an example is shown how to explain the application of linear function in routine life and its meaning in chemical and material engineering field. The example is about the quantitative detection of a blue dye’s concentration in the polluted water. Meanwhile, an advanced nanomaterial electrospun nanofibers was explored to treat the polluted water. The experiments were very vivid, greatly deepening the impressions of the junior high school students on the linear equation, enlightening their engineering cognition from a standpoint of mathematics. Enlightenment teaching of engineering cognition can be carried out on the junior high school students when they are taught about the fundamental mathematics knowledge. The Important Role of Mathematics in Engineering To a certain meaning, engineering is an application of science and mathematics [1]. Through this application, the material and energy properties of nature can be made efficient, reliable and useful to human beings in the shortest time and with the least human and material resources through various structures, machines, products, systems and processes. In modern society, the word "engineering" can be defined as the process of transforming an existing entity (natural or man-made) into an artificial product of anticipated use value through an organized group of people, using relevant scientific knowledge and technical means, based on a set of envisaged objectives. Fig. 1 The important role of mathematics in all kinds of engineering disciplines Engineering knowledge is mainly based on mathematics, physics, chemistry, and the resulting materials science, solid mechanics, fluid mechanics, thermodynamics, transport process and system analysis. According to the relationship between engineering and science, all branches of engineering have a wide variety of functions, such as research (applying concepts, principles and experimental 5th Annual International Conference on Social Science and Contemporary Humanity Development (SSCHD 2019) Copyright © 2019, the Authors. Published by Atlantis Press. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). Advances in Social Science, Education and Humanities Research, volume 376
Development and validation of a LC-ESI-MS/MS method for simultaneous whole blood analysis of 51 new psychoactive substances

In recent years, there has been a great increase in seizures and forensic analysis of new psychotropic substances (NPS) in the state of Rio Grande do Sul. The analysis of these compounds needs to be performed in biological samples in cases of violent deaths. A sensitive and reliable liquid chromatography-tandem mass spectrometry with electrospray ionization interface (LC-ESI-MS/MS) method was developed and validated for qualitative analysis of 51 NPS in whole blood forensic samples. Synthetic cathinones, phenethylamines, opioids, tryptamines, synthetic cannabinoids, and other hallucinogens and stimulants were included in the method. The validation parameters assessed were speciﬁcity, limit of detection, retention time precision, and matrix effect. Drug free pools (n=6) were used for validation, including post mortem samples as well as from living individuals. Adulterants, pharmaceuticals, metabolites, and other illicit drugs, totalling 39 compounds, were analyzed and no interference was noticed. The detection limits obtained were suitable for evaluation at recreational and non-fatal levels of consumption, mostly. The results revealed an appropriate matrix effect in 24 out of 51 substances tested, indicating the potential for future quantitative analysis with this method for these drugs. The developed and validated method is easy to implement, fast, with low cost, and suitable for use in routine forensic toxicology laboratory analysis.
Reconhecimento de Ações por RNA em Aplicações de Robótica Social

: Action recognition has been gaining interest in research due to its vast array of applications. In this paper, it is proposed an action recognition method using Artiﬁcial Neural Networks(ANN), applying a dimension reduction to the system inputs. This method is intended to be used on social robotics, thus it required a personalized dataset which has eleven action classes, being two of them neural actions. Dynamic Time Warping (DTW) is our base line for comparison and validation of the proposed method. method, already utilized in the literature. The simulations were done applying both methods to our dataset and show the results on confusion matrixes. The proposed method has a better performance than the DTW, specially considering the neutral actions with the other ones
Regional Mechanical Properties and Regeneration of the Mandibular Condylar Cartilage

The temporomandibular joint (TMJ) is one of the most complex articulating joints in the body. In addition, the surface of the condyle is mandibular condylar cartilage (MCC), which consists of different populations of cells within each of its layers. Damage or displacement to the disc and other abnormalities of the jaw can lead to eventual degeneration of the MCC. If downstream degeneration of the cartilage continues to progress, the avascular nature of the joint renders the tissue unable to regenerate on its own. Prior studies have attempted regeneration of the mandibular condyle with limited success. Regional viscoelastic properties of the MCC are also not well characterized, making the target of regeneration therapies unclear for this tissue. This dissertation aims to elucidate the regional mechanical properties, and providing a tissue engineering alternative through the use of soft biomaterials for the MCC. First, the regional compressive properties of the porcine TMJ disc and MCC were evaluated through the use of the transversely isotropic biphasic theory. Mechanical and viscoelastic properties of the five different regions of these tissues were evaluated and compared with one another. The results demonstrated higher compressive properties in the posterior region of the disc and also estimated the moduli in different planes, the Poisson’s ratio, and permeability of the MCC. Next, the focus shifted to determining the efficacy of using various soft biomaterials for the mandibular condyle regeneration of an osteochondral defect in the goat model. Acellular polyglycol sebacate and gelatin sponge scaffolds demonstrated cartilage regeneration with presence of collagen II and glycosaminoglycans after 3 months of healing. In hopes of using a cell-laden therapy, in vitro studies with BMSCs and also native cells of the mandibular condyle were conducted. Gelatin hydrogels supported differentiation of BMSCs towards a cartilage lineage, and a gelatin hydrogel composite supported chondrogenesis, and inhibited both mineralization and chondrocyte hypertrophy. Compressive properties of the in vitro scaffolds were also comparable to the measured values of the native MCC. The results of this dissertation give rise to an understanding of the viscoelastic properties of the MCC and give insight on promising soft biomaterials.
From Clinic to Program: PRIDe and the evolution of LGBTQ+ Healthcare at Einstein Medical Center Philadelphia

CONTINUED ON PAGE 2 In 2015, Dr. Michele Style, resident physician and co-founder of Einstein Health Network’s Pride Clinic, treated a patient who presented with advancedstage cervical cancer. Although the patient had health insurance and lived within walking distance of the hospital, she had avoided preventive care, including routine Pap smears. During the course of her treatment the woman disclosed that she identifies as a lesbian and feared she would be judged and unwelcome at the hospital due to her sexual orientation. As such, she had avoided pursuing life-saving screenings that could have prevented the progress of her cancer. Unfortunately, her story reflects a much larger trend in healthcare access and outcomes.
Fatores associados à pressão de língua em pacientes pós-acidente vascular cerebral

Introdução: A prática clínica fonoaudiológica no ambiente hospitalar mostra que existe alta prevalência de disfagia em pacientes pós-acidente vascular cerebral. Objetivo: Verificar se o tempo de ocorrência e o tipo do acidente vascular cerebral, o hemicorpo acometido por hemiplegia, a gravidade do deficit neurológico, a presença e o grau de disfagia interferem na pressão de língua de pacientes internados pós-acidente vascular cerebral. Métodos: Estudo realizado com 31 pacientes. Foi aplicado protocolo da avaliação da disfagia, prova de mobilidade lingual e mediu-se a pressão de língua com o Iowa Oral Performance Instrument (IOPI). Foram realizadas três medidas da pressão anterior e três da pressão posterior. Os dados foram analisados por meio de estatística apropriada, com nível de significância de 5%. Resultados: Apenas a presença de disfagia se mostrou associada estatisticamente à pressão de língua, sendo que os pacientes pós-acidente vascular cerebral disfágicos apresentaram pressão anterior e posterior média e máxima da língua menor que aqueles sem a presença de disfagia. O tempo de ocorrência do acidente vascular cerebral, o tipo e o hemicorpo acometido e a gravidade do deficit neurológico não apresentaram associação com a pressão lingual. Dentre os 15 participantes que apresentaram a dificuldade de deglutição, 14 (93,3%) foram classificados com disfagia leve e um (6,7%) com disfagia moderada. Conclusão: Verificou-se que a disfagia, ainda que de grau leve, foi o fator preponderante para diminuição da pressão de língua em pacientes que sofreram acidente vascular cerebral.
On convergence of subspaces generated by dilations of polynomials. An application to best local approximation

We study the convergence of a net of subspaces generated by dilations of polynomials in a finite dimensional subspace. As a consequence, we extend the results given by Zó and Cuenya [Advanced Courses of Mathematical Analysis II (Granada, 2004), 193–213, World Scientific, 2007] on a general approach to the problems of best vector-valued approximation on small regions from a finite dimensional subspace of polynomials.