Miracle-dz/UniFAR-FTUs huggingface dataset:
Urocytograms in normal children and various abnormal conditions.

Urethral cytology was quantitated and the results analyzed statistically with the following new findings. Increased estrogen effect in prepubertal girls compared to male controls. Increased estrogen effect in postpubertal compared to prepubertal males. Estrogen effect was partially blocked by the agent or agents causing premature adrenarche. Depo-Provera produced a change in the cytology of girls with sexual precocity similar to that produced in adult subjects by progestational steroid administration. Non-nucleated cells, not previously quantitated in pediatric patients, varied inversely with increased estrogen effect. In addition, the recently reported findings of increased estrogen effect in premature thelarche and adolescent gynecomastia were confirmed.
AEROBIC AND ANAEROBIC BACTERIAL COUNTS OF NASAL WASHINGS: PRESENCE OF ORGANISMS RESEMBLING CORYNEBACTERIUM ACNES

Watson, Elinor D. (Washington University, St. Louis, Mo.), Nanci J. Hoffman, Richard W. Simmers, and Theodor Rosebury. Aerobic and anaerobic bacterial counts of nasal washings: Presence of organisms resembling Corynebacterium acnes. J. Bacteriol. 83:144–148. 1962. —Aerobic and anaerobic colony counts in blood agar were made of 40 samples of nasal washings from five healthy adults. The anaerobic counts were consistently and significantly higher, in line with findings previously reported by others for skin, saliva, and feces. Catalase-forming diphtheroids utilizing lactate anaerobically, tentatively identified as members of the Corynebacterium acnes group, were conspicuous in the anaerobic cultures.
Direct Detection and Coherent Optical Time-Domain Reflectometry With Golay Complementary Codes

We extend the Golay coded Optical Time Domain Reflectometry OTDR technique for the first time from direct-detection to coherent OTDR, investigating the unique issues arising in the coherent setting regarding signal processing operations and efficient real-time implementation of the DSP in practical coherent OTDR receivers and the resulting OTDR performance. We also derive detailed signal flow block diagrams for direct-detection and coherent OTDRs and use an intuitive analogy between spatial speckle and temporal coherent fading noise to guide the selection of OTDR system parameters. We present extensive simulations of the OTDR signal and noise flow accounting for all major effects including the optical source coherence and the backscatter random fading.
Survey of Service Description Languages and Their Issues in Cloud Computing

Along with the growing popularity of cloud computing technology, the amount of available cloud services and their usage frequency are increasing. In order to provide a mechanism for the efficient enforcement of service-relevant operations in cloud environment, such as service discovery, service provision, and service management, a completed and precise service specification model is highly required. In this paper, we conducted a survey on existing service description languages applied in three different domainsgeneral services, Web/SOA services, and cloud services. We discussed and compared the past literature from seven major aspects, which are: (1) domain, (2) coverage, (3) purpose, (4) representation, (5) semantic expressivity, (6) intended users, and (7) features. Additionally, two core dimensions semantic expressivity and coverage are employed to categorize and analyse the key service description languages by using Magic Quadrant methodology. These two dimensions are regarded as the most essential factors for the evaluation of a service description model. Based on this analysis, we concluded that Unified Service Description Language (USDL) is the language with the widest coverage from business, technical and operational aspects, while OWL-S is the one that has the highest semantic expressivity. At last, critical research issues on cloud service description languages are identified and analysed. The solution of these issues requires more research efforts on the standardization of cloud service specification, which will eventually enhance the development of cloud industry.
Developmental expression pattern of the cdo gene

CDO is a cell‐surface protein of the immunoglobulin/fibronectin type III repeat family that positively regulates myogenic differentiation in vitro. To gain a better understanding of the role of cdo during vertebrate development, we carried out an extensive in situ hybridization study to characterize its expression pattern from postimplantation to late stages of mouse embryogenesis and in rat brain from E13 to adult. Our results show a broad pattern of cdo expression that is spatially and temporally restricted during embryogenesis. In the central nervous system (CNS), cdo expression is detected as early as E7.5 and maintained in the dorsal ventricular zones of the brain and spinal cord, becoming increasingly restricted in the adult. High levels of cdo are detected in developing sensory organs, such as the eye and ear. Outside the CNS, cdo is expressed mainly in neural crest and mesodermal derivatives, including skeletal muscle precursors. Overall, the highest levels of cdo expression are seen from E9.0 to E15.5. The temporal onset and restricted expression of cdo suggest that cdo plays a role in the determination and/or differentiation of a number of cell types during embryogenesis. © 2000 Wiley‐Liss, Inc.
The impact of foot ulceration and amputation on mortality in diabetic patients. I: From ulceration to death, a systematic review

A great deal of emphasis, clinical and financial, is placed on limb salvage efforts in diabetic patients suffering from lower extremity ulceration. This is because of the impression that amputation in such patients may be a proximal cause of death. While amputation is certainly a negative clinical outcome, it is not entirely clear that it causes death.
The Orbiten Free Software Survey

Free software is supposedly developed by a loosely organised "community" of programmers. However it has been quite unknown until now who, except for some well-known celebrities, belongs to this community, and more importantly how contributions are distributed. The authors present a first survey of free software authorship, with the emphasis not on building a census or even a "hall of fame", but on identifying patterns of concentration and distribution of contribution. The sample code size is not necessarily representative and there are several errors due to the automated and vast nature of the task of identifying and crediting authors. Nevertheless, comprehensive data is collated for the first time, and can be scrutinised in detail on the survey Web site.
Balanced Bandpass Filter Using Stub-Loaded Ring Resonator and Loaded Coupled Feed-Line

A balanced bandpass filter is proposed based on stub-loaded ring resonators (SLRRs) and loaded coupled feed-lines (CFLs) with high selectivity and common-mode (CM) rejection. By controlling the coupling coefficient of the CFLs, three transmission poles within the differential passband are achieved. The CFLs are loaded with open- and short-circuited stubs at the end of the traditional parallel-coupled feed-lines, which resulting in multiple transmission zeros (TZs) in differential mode (DM) and CM to improve the passband selectivity and CM suppression, simultaneously. Finally, the proposed filter is designed and fabricated, the simulated and measured results are in good agreement. The filter shows low insertion loss, multiple transmission zeros, high selectivity and enhanced CM rejection.
Occupational asthma cases notified to OSH from 1996 to 1999.

AIMS To update notifications to the Occupational Safety and Health Service of the Department of Labour (OSH) Notifiable Occupational Disease System (NODS) from June 1996 to the beginning of 1999. METHODS All notifications received for non-asbestos related occupational respiratory disease were reviewed to confirm the clinical diagnosis, occupational causation, and to identify the causative agent where possible. RESULTS 54 cases of asthma were notified, of which 21 (39%) were accepted as being occupationally caused. These cases arose from 'predictable' industries. CONCLUSIONS NODS offers sentinel data from interested practitioners and workplaces. Occupational asthma and other occupational respiratory diseases remain poorly notified to this system. NODS confirms the presence of occupational asthma in New Zealand from predictable and preventable causes not dissimilar to other countries. This data collection system needs supplementation by other mechanisms.
Allosuppression of B cells in vitro by graft‐vs.‐host reaction‐derived T cells is caused by cytotoxic T lymphocytes

An acute graft‐vs.‐host reaction (GVHR) was induced by i.v. injection of 108 lymphoid cells from C57BL/10 (B10) donors (H‐2b/b) into adult non‐irradiated (B10 x DBA/2)F1 mice (H‐2b/d). Previous experiments have established that spleen cells obtained from such GVHF1 mice suppress the primary antibody response of normal F1 spleen cells to sheep red blood cells. This type of suppression was termed “allosuppression”, and it was shown to be mediated by Ly‐2+ T cells of donor origin that react against H‐2 antigens of the host. It was unclear, however, whether the actual mechanism of allosuppression was due to suppressive factors generated by donor T cells or whether the latter killed the F1 B cells. Here, we show that for their suppressive effect GVHF1 spleen cells need direct cell contact with F1 spleen cells; no suppressive effect was measured in a double‐chamber culture system in which the GVHF1 spleen cells were separated from the responding normal F1 spleen cells by a cell‐tight membrane filter. The suppressive effect only affected cells expressing the appropriate H‐2 class I alloantigen; in mixed cultures of irradiated F1 spleen cells and GVHF1 spleen cells with third‐party B cells the antibody response of the third‐party B cells was not suppressed. GVHF1 spleen cells showed cytotoxic T lymphocyte (CTL) activity specific for the allogeneic F1 H‐2 antigen. The suppressive effect of the GVHF1 spleen cells did not differ from that exerted by cloned CTL specific for MHC class I alloantigens; cloned CTL suppressed the primary antibody response of murine spleen cells without affecting the response of third‐party B cells added to the cultures. The combined findings show that “allosuppression” in vitro is not due to suppression of F1 B cells, but to a direct killing of these cells by alloreactive CTL.
Proteomic characterization of the effects of clofibrate on protein expression in rat liver

Clofibrate is a peroxisome proliferator known to induce liver tumours in rats. A proteomics study was conducted to provide new insights into the molecular mechanisms of clofibrate‐induced non‐genotoxic hepatocarcinogenesis. Rats were treated with 250 mg/kg day clofibrate orally and sacrificed after 7 days. Proteins extracted from the liver were analysed by 2‐DE using DIGE technology. The protein identification performed by MS showed that clofibrate induced up‐regulation of 77 proteins and down‐regulation of 27 proteins. The highest expression ratios corresponded to proteins involved in a series of biochemical pathways such as lipid metabolism, fatty acid metabolism, amino acid metabolism, protein metabolism, citric acid cycle, xenobiotic detoxification and oxidative stress. Proteins implicated in cell proliferation and apoptosis, such as prohibitin, 10‐formyl tetrahydrofolate dehydrogenase, senescence marker protein‐30, pyridoxine 5'‐phosphate oxidase and vimentin, were also identified as being regulated. These results provide leads for further investigations into the molecular mechanisms of liver tumours induced by clofibrate. In addition, MS results showed that a series of regulated proteins were detected as several spots corresponding to different pI and/or Mr. Differential effects on those variants could result from specific PTM and could be a specific molecular signature of the clofibrate‐induced protein expression modulation in rat liver.
Immunomodulation in Endometrial Cancer

Endometrial cancer is the most frequent gynecological cancer and the fourth most common cancer in women in the developed world. Over the last decade, immunotherapy has been the focus of intense investigation as a form of cancer treatment whereby the treatment initiates a host immune response ultimately eradicating the tumor. It has been suggested that in endometrial cancer and many other forms of cancer, immunosuppression poses a significant obstacle at inducing antitumor immunity by immunotherapy. This review will look at the different studies that have identified immunomodulation of T cells, cytokines and macrophages, and regulation of apoptotic and angiogenic factors in endometrial cancer patients that may contribute to the inefficiency of immunotherapy.
Rickettsia parkeri as a Paradigm for Multiple Causes of Tick‐Borne Spotted Fever in the Western Hemisphere

Abstract: Among the many contributions made to rickettsiology by entomologist and rickettsiologist Ralph R. Parker was his discovery in 1937 of a novel rickettsia isolated from the Gulf Coast tick, Amblyomma maculatum. This bacterium was subsequently characterized as a unique rickettsial species in 1965 and named Rickettsia parkeri in honor of its discoverer. During the next several decades R. parkeri was generally considered as one of several “nonpathogenic” spotted fever group (SFG) rickettsiae that resided in ticks of the United States. The identification of novel rickettsioses on other continents during the last two decades of the twentieth century provided important evidence of the frequent coexistence of multiple and unique tick‐borne SFG rickettsiae sharing common geographic regions. Surprisingly, this paradigm, which was repeatedly demonstrated in Europe, Africa, and Australia during the last 10 years, had no confirmed correlate in the United States until 2002, when R. parkeri was isolated from a patient from the state of Virginia. Several pieces of epidemiologic, laboratory, and clinical evidence are compelling enough to suggest that this infection has occurred in other U.S. patients who reside within the range of the Gulf Coast tick. Just as important are new data indicating relatively high infection rates of A. maculatum ticks with R. parkeri, documenting the occurrence of R. parkeri in Amblyomma triste ticks from Uruguay, and providing evidence that other Amblyomma species might serve as efficient vectors of R. parkeri. The recognition of R. parkeri as a cause of disease in humans will hopefully encourage a closer examination for specific etiologies of tick‐borne spotted fever rickettsioses in the United States and other countries of the Western Hemisphere.
Al-Quran themes classification using ontology

Knowledge representations of Al-Quran involved the classification of contents for understanding the readers.In information technology environment, the representation and classification approaches must be understood by human and computer in order to ensure the correct semantics of Al-Quran knowledge.Current approaches used conventional methods such as taxonomy, hierarchy or tree structure, which only provides a concept definition without linked to another possibility of knowledge explanation.This research aims to explore the approach to represent and classify the Al-Quran knowledge by using ontology.The ontology model for Al-Quran is developed according to the themes of Al-Quran knowledge as described in Syammil Al-Quran Miracle the Reference.The ontology approach has shown that the Al-Quran knowledge can be classified and presented to the readers systematically. Moreover, the ontology structure that representing the relationships among the theme concepts in Al-Quran was reviewed and validated by the domain experts in Al-Quran.
Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor(*)

The mitogen-activated protein kinase (MAP kinase) pathway is thought to play an important role in the actions of neurotrophins. A small molecule inhibitor of the upstream kinase activator of MAP kinase, MAP kinase kinase (MEK) was examined for its effect on the cellular action of nerve growth factor (NGF) in PC-12 pheochromocytoma cells. PD98059 selectively blocks the activity of MEK, inhibiting both the phosphorylation and activation of MAP kinases in vitro. Pretreatment of PC-12 cells with the compound completely blocked the 4-fold increase in MAP kinase activity produced by NGF. Half-maximal inhibition was observed at 2 μM PD98059, with maximal effects at 10-100 μM. The tyrosine phosphorylation of immunoprecipitated MAP kinase was also completely blocked by the compound. In contrast, the compound was without effect on NGF-dependent tyrosine phosphorylation of the pp140 receptor or its substrate Shc and did not block NGF-dependent activation of phosphatidylinositol 3′-kinase. However, PD98059completely blocked NGF-induced neurite formation in these cells without altering cell viability. These data indicate that the MAP kinase pathway is absolutely required for NGF-induced neuronal differentiation in PC-12 cells.
Different Microtubule Motors Move Early and Late Endocytic Compartments

Important progress has been made during the past decade in the identification of molecular motors required in the distribution of early and late endosomes and the proper trafficking along the endocytic pathway. There is little direct evidence, however, that these motors drive movement of the endosomes. To evaluate the contributions of kinesin‐1, dynein and kinesin‐2 to the movement of early and late endosomes along microtubules, we made use of a cytosol‐free motility assay using magnetically isolated early and late endosomes as well as biochemical analyses and live‐cell imaging. By making use of specific antibodies, we confirmed that kinesin‐1 and dynein move early endosomes and we found that kinesin‐2 moves both early and late endosomes in the cell‐free assay. Unexpectedly, dynein did not move late endosomes in the cell‐free assay. We provide evidence from disruption of dynein function and latrunculin A treatment, suggesting that dynein regulates late endosome movement indirectly, possibly through a mechanism involving the actin cytoskeleton. These data provide new insights into the complex regulation of endosomes’ motility and suggest that dynein is not the major motor required to move late endosomes toward the minus end of microtubules.
Osteogenesis imperfecta in childhood: prognosis for walking.

OBJECTIVES We studied the predicted value of disease-related characteristics for the ability of children with osteogenesis imperfecta (OI) to walk. STUDY DESIGN The severity of OI was classified according to Sillence. The parents were asked to report the age at which the child achieved motor milestones, the fracture incidence, and the age and localization of the first surgical intervention. The present main means of mobility was classified according to Bleck. RESULTS There were 76 replies to the 98 questionnaires, of which 70 were included (type I, 41; type III, 11; type IV, 18). The type of OI was strongly associated with current walking ability, as was the presence of dentinogenesis imperfecta. Patients with type III and IV had a lower chance of ultimately walking compared with those with type I. Children with more than 2 intramedullary rods in the lower extremities had a reduced chance of walking than patients without rods. Rolling over before 8 months, unsupported sitting before 9 months, the ability to get in sitting position without support before 12 months, and the ability to get in a standing position without support before 12 months showed positive odds ratios. In Bleck > or = 4, multivariate analysis revealed that only the presence of rodding (yes/no) in the lower extremities had additional predictive value to the type of OI. The presence of dentinogenesis imperfecta and rodding (yes/no) had additional value in Bleck > or = 5. CONCLUSION The type of OI is the single most important clinical indicator of the ultimate ability to walk. Information about motor development adds little. The early achievement of motor milestones contributes to the ability of independent walking when the type of OI is uncertain. Intramedullary rodding of the lower extremities is primarily related to the severity of the disease and in this way provides consequences for the ability to walk.
A survey of problems and approaches in wireless-based indoor positioning

Indoor positioning is a key technology that enables the development of various smart and autonomous indoor applications. In recent years, wireless device is considered a promising technology enabler for indoor positioning despite facing various problems in the form of spatial, temporal, and device variation. Here we present a survey of problems in wireless-based indoor positioning and the state-of-the-art approaches aimed to solving those problems. This survey paper discusses various positioning metrics, parametric and non-parametric models to deal with spatial and temporal variation, as well as various methods that address device heterogeneity. In addition, some interesting fusion approaches are discussed. This paper aims to help researchers understand the current state of progress in wireless-based indoor positioning and identify areas that still need more research and improvement.
Clinical, genetic, and biochemical characterization of a Leber hereditary optic neuropathy family containing both the 11778 and 14484 primary mutations.

Four mitochondrial DNA (mtDNA) mutations at nps 3460, 11778, 14484, and 14459 account for roughly 90% of cases of Leber hereditary optic neuropathy (LHON) and are designated as "primary" LHON mutations since they act as major predisposition factors for LHON. Although each primary mutation can arise independently on different mtDNA backgrounds during human evolution, they characteristically do not co-occur in LHON patients. We report here a family with the simultaneous occurrence of the 11778A and 14484C mutations. Neuro-ophthalmological examination of the proband, a nine-year-old Caucasian female, revealed the bilateral optic atrophy, central scotomas, and reduced visual acuity typical of LHON. Her mother had normal appearing optic discs and is today visually asymptomatic. Analysis of the proband blood mtDNA revealed that she harbored both the 11778A (heteroplasmic, 94% mutant) and the 14484C (homoplasmic mutant) mutation. This genotype was maintained in proband lymphoblasts and transmitochondrial cybrids. The mother also had both mutations, with the 14484C mutation homoplasmic in all cell types examined. However, only 31% of her blood mtDNAs carried the 11778 mutation, which segregated to essentially 100% wild-type in lymphoblast and cybrid mtDNA. Complex I-linked respiration and specific enzyme activity were consistently lowest in proband lymphoblast and cybrid mitochondria compared to those from the mother, 11778A patients, 14484C patients, or controls, thus demonstrating both a deleterious synergistic interaction between the 11778A and 14484C mutations and the magnitude of 11778A-associated complex I dysfunction. Remarkably, spontaneous vision recovery occurred in the proband, highlighting the complexities encountered when associating mtDNA genotype and complex I function with LHON expression.