Miracle-dz/UniFAR-FTUs huggingface dataset:
Environmental polycyclic aromatic hydrocarbons mixture, in human blood levels, decreased oestradiol secretion by granulosa cells via ESR1 and GPER1 but not ESR2 receptor

Tissue-dependent oestrogenic and anti-oestrogenic activity of polycyclic aromatic hydrocarbons (PAHs) has been suggested. In this study, the effect of two PAH mixtures, M1 composed of all 16 priority pollutants and M2 composed of five (noted in the highest levels) compounds, on follicle-stimulating hormone receptor (FSHR) expression, basal or FSH-induced oestradiol (E2) secretion and aromatase cytochrome P450 (P450arom) protein expression, by non-luteinised human granulosa cell line (HGrC1) was determined. In addition, the consequences of gene silencing of oestrogen receptor alfa (siESR1), oestrogen receptor beta (siESR2) and a G protein-coupled receptor (siGPER1) on the above parameters were described. Neither PAH mixture had an effect on basal FSHR protein expression; however, both mixtures increased FSH-induced FSHR expression. Decreased E2 secretion and P450arom expression was also demonstrated. In both basal and FSH treated cells, siESR1 and siGPER1 reversed the inhibitory effect of the mixtures on E2 secretion; however, in siESR2 cells, the inhibitory effect was still observed. This study showed that both classic ESR1 and GPER1 were involved in the inhibitory effect of both PAH mixtures on E2 secretion and confirmed that expression of P450arom could be downregulated through the aryl hydrocarbon receptor and additionally through the ESR2.
Blink: Fast Connectivity Recovery Entirely in the Data Plane

We present B link, a data-driven system that leverages TCP-induced signals to detect failures directly in the data plane. The key intuition behind B link is that a TCP ﬂow exhibits a predictable behavior upon disruption: retransmitting the same packet over and over, at epochs exponentially spaced in time. When compounded over multiple ﬂows, this behavior creates a strong and characteristic failure signal. B link efﬁciently analyzes TCP ﬂows to: (i) select which ones to track; (ii) reliably and quickly detect major trafﬁc disruptions; and (iii) recover connectivity—all this, completely in the data plane. We present an implementation of B link in P4 together with an extensive evaluation on real and synthetic trafﬁc traces. Our results indicate that B link: (i) achieves sub-second rerouting for large fractions of Internet trafﬁc; and (ii) prevents unnecessary trafﬁc shifts even in the presence of noise. We further show the feasibility of B link by running it on an actual Toﬁno switch.
Exploration of Wireless Sensor Network Based on RSSI Positioning Algorithm

<p class="0abstract"><span lang="EN-US">Based on the security of the receiving signal strength indicator positioning algorithm, the RSSI positioning algorithm in the environment of witch attack, wormhole attack and replication attack has largely failed</span><span lang="EN-US">. </span><span lang="EN-US">Although existing security </span><span lang="EN-US">positioning</span><span lang="EN-US"> algorithms can effectively prevent attacks from occurring, the massive consumption of network resources can’t be ignored. </span><span lang="EN-US">Therefore, a tolerable security positioning method is proposed for each of the three attacks in order to improve the security of positioning. </span><span lang="EN-US">According to the node's physical information, the attack node is detected. </span><span lang="EN-US">Through simulation experiments, compared with the traditional indoor security </span><span lang="EN-US">positioning</span><span lang="EN-US"> method, the proposed algorithm can significantly reduce the intervention of witch attack, wormhole attack and replication attack on positioning error. </span><span lang="EN-US">While achieving the goal of combating attacks, it reduces the computational complexity, decreases node energy consumption, and extends the network life cycle. </span></p>
Loom: Flexible and Efficient NIC Packet Scheduling

In multi-tenant cloud data centers, operators need to ensure that competing tenants and applications are isolated from each other and fairly share limited network resources. With current NICs, operators must either 1) use a single NIC queue and enforce network policy in software, which incurs high CPU overheads and struggles to drive increasing line-rates (100Gbps), or 2) use multiple NIC queues and accept imperfect isolation and policy enforcement. These problems arise due to inﬂexible and static NIC packet schedulers and an inefﬁcient OS/NIC interface. To overcome these limitations, we present Loom, a new NIC design that moves all per-ﬂow scheduling decisions out of the OS and into the NIC. The key aspects of Loom’s design are 1) a new network policy abstraction: restricted directed acyclic graphs (DAGs), 2) a programmable hierarchical packet scheduler, and 3) a new expressive and efﬁcient OS/NIC interface that enables the OS to precisely control how the NIC performs packet scheduling while still ensuring low CPU utilization. Loom is the only multiqueue NIC design that is able to efﬁciently enforce network policy. We ﬁnd empirically that Loom lowers latency, increases throughput, and improves fairness for collocated applications and tenants.
Spatial synchrony in the response of a long range migratory species (Salmo salar) to climate change in the North Atlantic Ocean

A major challenge in understanding the response of populations to climate change is to separate the effects of local drivers acting independently on specific populations, from the effects of global drivers that impact multiple populations simultaneously and thereby synchronize their dynamics. We investigated the environmental drivers and the demographic mechanisms of the widespread decline in marine survival rates of Atlantic salmon (Salmo salar) over the last four decades. We developed a hierarchical Bayesian life cycle model to quantify the spatial synchrony in the marine survival of 13 large groups of populations (called stock units, SU) from two continental stock groups (CSG) in North America (NA) and Southern Europe (SE) over the period 1971–2014. We found strong coherence in the temporal variation in postsmolt marine survival among the 13 SU of NA and SE. A common North Atlantic trend explains 37% of the temporal variability of the survivals for the 13 SU and declines by a factor of 1.8 over the 1971–2014 time series. Synchrony in survival trends is stronger between SU within each CSG. The common trends at the scale of NA and SE capture 60% and 42% of the total variance of temporal variations, respectively. Temporal variations of the postsmolt survival are best explained by the temporal variations of sea surface temperature (SST, negative correlation) and net primary production indices (PP, positive correlation) encountered by salmon in common domains during their marine migration. Specifically, in the Labrador Sea/Grand Banks for populations from NA, 26% and 24% of variance is captured by SST and PP, respectively and in the Norwegian Sea for populations from SE, 21% and 12% of variance is captured by SST and PP, respectively. The findings support the hypothesis of a response of salmon populations to large climate‐induced changes in the North Atlantic simultaneously impacting populations from distant continental habitats.
Identification and Management of Insomnia in Alzheimer's Disease.

As a continuing medical education provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), Primary Care Education Consortium (PCEC) requires any individual in a position to influence educational content to disclose any financial interest or other personal relationship with any commercial interest. This includes any entity producing, marketing, re-selling or distributing health care goods or services consumed by, or used on, patients. Mechanisms are in place to identify and resolve any potential conflict of interest prior to the start of the activity. In addition, any discussion of off-label, experimental, or investigational use of drugs or devices will be disclosed by the faculty. Dr. Roth discloses that he serves on the advisory boards for Eisai, Idorsia Janssen, Jazz, and Merck.
A Fast and Efficient Measurement System for Nuclear Spin Relaxation Times in Atomic Vapors

With the rapid progress of cutting-edge research such as quantum measurement technology, nuclear magnetic resonance (NMR) gyroscopes represent a major development direction of high-precision micro-miniature gyroscopes, which have significant advantages such as high precision, small size, and low power consumption. It is meaningful to measure the relaxation times of noble-gas atoms which are crucial indicators to accurately and quickly characterize the vapor cell performance as a core component of gyroscopes. In this paper, a test platform for relaxation time is built and an automatic relaxation time test system based on free induction decay (FID) and the π pulse method is designed to accelerate the relaxation time test. Firstly, the formula of the atomic dynamic process based on the Bloch equation was deduced, a GUI (Graphical User Interface) simulation based on the derived differential equation was conducted, and the moving process of the magnetic moment was visually described. Then, the virtual instrument was used to integrate multiple test instruments into an auto-test system, and LabVIEW programming was used for control to realize the automation of the test process on the test platform. Finally, the test results in different conditions were compared. The results show that the test system is stable and reliable with excellent man–machine interaction, and the measurement efficiency was increased by about 185%, providing an effective test scheme for vapor cell performance.
Zika and Flavivirus Shell Disorder: Virulence and Fetal Morbidity

Zika virus (ZIKV) was first discovered in 1947 in Africa. Since then, sporadic ZIKV infections of humans have been reported in Africa and Asia. For a long time, this virus was mostly unnoticed due to its mild symptoms and low fatality rates. However, during the 2015–2016 epidemic in Central and South America, when millions of people were infected, it was discovered that ZIKV causes microcephaly in the babies of mothers infected during pregnancy. An examination of the M and C proteins of the ZIKV shell using the disorder predictor PONDR VLXT revealed that the M protein contains relatively high disorder levels comparable only to those of the yellow fever virus (YFV). On the other hand, the disorder levels in the C protein are relatively low, which can account for the low case fatality rate (CFR) of this virus in contrast to the more virulent YFV, which is characterized by high disorder in its C protein. A larger variation was found in the percentage of intrinsic disorder (PID) in the C protein of various ZIKV strains. Strains of African lineage are characterized by higher PIDs. Using both in vivo and in vitro experiments, laboratories have also previously shown that strains of African origin have a greater potential to inflict higher fetal morbidity than do strains of Asian lineage, with dengue-2 virus (DENV-2) having the least potential. Strong correlations were found between the potential to inflict fetal morbidity and shell disorder in ZIKV (r2 = 0.9) and DENV-2 (DENV-2 + ZIKV, r2 = 0.8). A strong correlation between CFR and PID was also observed when ZIKV was included in an analysis of sets of shell proteins from a variety of flaviviruses (r2 = 0.8). These observations have potential implications for antiviral vaccine development and for the design of cancer therapeutics in terms of developing therapeutic viruses that penetrate hard-to-reach organs.
Overcoming developing world challenges of cochlear implantation: Chinese perspective

Purpose of review Over a short period, China has adopted cochlear implants and emerged as a burgeoning market. This represents a valuable case study for emerging countries in terms of planning, initiating, and growing cochlear implant programs. Recent findings Although many challenges such as funding, establishing infrastructure, and recipient community support have been addressed, many more remain. Consistent rapid escalation in numbers has been driven by push-and-pull factors. Federal, state, and private funding have all played a role. Summary The review highlights the massive need for hearing rehabilitation that currently exists in China. The shortfall can only be addressed by a purposeful and coordinated approach involving government policy, The China Disabled Persons Federation, the industry partnering with hearing and medical professionals and the deaf community.
Evaluation of the Toxicity and Neurological Effects of Fulranumab in Adult Cynomolgus Monkeys

Fulranumab, an anti-human nerve growth factor antibody, was evaluated in a series of nonclinical toxicology studies. No treatment effects were observed in adolescent cynomolgus monkeys in standard design, repeat-dose toxicology studies of up to 6 months. Adverse effects on the developing nervous system were observed in offspring of pregnant cynomolgus monkeys treated with fulranumab. Subsequent studies including detailed morphologic investigations of the nervous system did reveal fulranumab-related changes in adult cynomolgus monkeys; this article is focused on those findings. A single dose of ≥1 mg/kg fulranumab administered subcutaneously (SC) caused a decrease in neuron and sympathetic ganglion size (superior cervical ganglion), observed morphologically and stereologically, with a resulting appearance of increased glial cell density. Similar results were observed in repeat-dose (15 to 52 weeks) toxicity studies at ≤50 mg/kg/wk fulranumab SC. These effects recovered after a 3-month treatment-free period. Fulranumab did not cause any neuronal death, necrosis, apoptosis, or any apparent decrease in function of sympathetic neurons/ganglia at any time point examined. A no observed effect level (NOEL) was established at 0.25 mg/kg fulranumab SC every 4 weeks for 28 weeks.
The efficacy of combined l‐carnitine and l‐acetyl carnitine in men with idiopathic oligoasthenoteratozoospermia: A systematic review and meta‐analysis

The purpose of our analysis is to identify the effect of l‐carnitine (LC) and l‐acetyl carnitine (LAC) on the semen parameters of men with idiopathic oligoasthenoteratozoospermia (iOAT). We performed a comprehensive search to ascertain all the trials about LC and LAC in the treatment of iOAT and compared the results, including percentage of total sperm motility, sperm concentration, percentage of forward sperm motility, semen volume, percentage of atypical forms, total motile spermatozoa, forward motile spermatozoa and the number of pregnancies between the two groups that treated with LC + LAC or placebo respectively. Seven randomised controlled trials (RCTs) involving 693 patients were included in our analysis. We found that patients who treated with LC and LAC had significantly increased the percentage of forward sperm motility (MD 6.98; 95% CI 1.06–12.90; p = .02), total motile spermatozoa (MD 16.45; 95% CI 8.10–24.79; p = .0001), forward motile spermatozoa (MD 13.01; 95% CI 11.08–14.94; p < .00001) and the number of pregnancies (OR 3.76; 95% CI 1.66–8.50; p = .002). However, no significant differences were found in other semen indicators between the two groups. LC and LAC can significantly increase part of the semen parameters. The combination therapy of LC and LAC is effective in the men with iOAT.
Are the measurement properties of incremental exercise tests similar between patients with COPD and CHF?

We investigated whether the differences in exercise limitation between patients with chronic obstructive pulmonary disease (COPD) or chronic heart failure (CHF) affect the repeatability or responsiveness of incremental exercise tests. Patients with COPD (Medical Research Council dyspnoea grade 2–5) and patients with CHF (New York Heart Association class II–IV) performed two incremental shuttle walk tests (ISWT) following familiarisation and two incremental cycle ergometer tests (ICE) within 2 weeks. Both tests were repeated on completion of a pulmonary rehabilitation (PR) programme. One hundred and twelve patients were recruited. In response to exercise, patients with COPD were more likely than patients with CHF to have a ventilatory limitation (p < 0.001) and less likely to have a cardiovascular limitation (p < 0.001). The ISWT distance and ICE peak volume of oxygen uptake (VO2Peak) were similarly repeatable (p = 0.11 and p = 0.47 for time and disease effect) and responsive to PR (p = 0.44 and p = 0.67) between diseases. There was no difference in repeatability or responsiveness with either a ventilatory or cardiovascular limitation to exercise (p > 0.20 for all comparisons). The coefficient of repeatability across the cohort was 60 m for the ISWT and 0.270 L/minute for ICE VO2Peak. The minimum important difference (MID) for the ISWT in both diseases for PR was 30 m. The repeatability and responsiveness of the ISWT distance and ICE VO2Peak are similar between patients with COPD and CHF and are unaffected by differences in exercise limitation. A change of 60 m in the ISWT or 0.270 L/minute in ICE VO2Peak is required to be 95% certain that a true change has occurred within an individual patient. For a group of patients with either COPD or CHF, the MID for the ISWT distance is estimated to be 30 m.
Complex, Contemporary, and Unconventional

In the 2018 U.S. midterm elections, a record number of Native American candidates ran for office at all levels of government. To better understand how these 104 candidates intersected with Indigenous political issues and movements to increase Native American voter turnout, we study 723,269 tweets about or by these candidates and 15,476 tweets associated with the #NativeVote movement between October 6, 2018 and February 5, 2019. We use a mixed methods approach to identify issues that emerge in the Native Candidates data set, including issues of representation and protean usage of the "Make America Great Again" hashtag #maga. When examining the feeds of selected candidates, we find that there can be a disconnect between the issues that candidates align themselves with on social media and the issues that they are associated with by others. We also find evidence of Indigenous issues spanning a vast political spectrum and being coupled with other issues in different ways by different candidates and audiences. Finally, we examine the intersection between Native American candidates and the\#NativeVote movement to discover emergent issue networks, including networks around voter suppression and Indigenous political action. Critically, we discuss how our interdisciplinary Indigenous feminist approach to social media analysis illuminates issues of marginalized communities in both a systematic and inductive manner that allows us to discover new patterns and issues with limited a priori knowledge about a complex system.
Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches

Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II which causes vasoconstriction. ACE inhibitors reduce blood pressure by inhibiting ACE. A well-known adverse drug reaction to ACE inhibitors is ACE inhibitor-induced angioedema (ACEi-AE). Angioedema is a swelling of skin and mucosa, which can be fatal if the airway is compromised. We have performed a systematic review of the evidence suggesting that genetic polymorphisms are associated with ACEi-AE and evaluated the methodological approaches of the included studies. The Cochrane Database of Systematic Reviews, Google Scholar, and PubMed were searched. Studies investigating the association between genetic markers and ACEi-AE were included. The Q-genie tool was used to evaluate the quality of the study methodologies. Seven studies were included. With the exception of one whole genome study, all of the included studies were candidate gene association studies. Study quality assessment scores ranged from 36 to 55. One study was found to be of good quality, suggesting that the detected associations may be unreliable. The inferior quality of some studies was due to poor organization, lack of analyses and missing information. Polymorphisms within XPEPNP2, BDKRB2–9/+ 9 and neprilysin genes, were reported to be associated with increased risk of ACEi-AE. However, due to low quality, these associations need to be confirmed in larger studies.
MicroRNA‐576‐5p enhances the invasion ability of trophoblast cells in preeclampsia by targeting TFAP2A

Preeclampsia (PE) is a common pregnancy‐related syndrome characterized by hypertension and proteinuria, and a major cause of maternal mortality. Therefore, there is an urgent need to identify early biomarkers of PE. The aim of the present study was to identify the functions of miR‐576‐5p in PE.
Hair cortisol levels and mental health problems in children and adolescents exposed to victimization

Abstract Youths who experience multiple forms of victimization are at a heightened risk for psychopathology across the lifespan. The hypothalamic-pituitary-adrenal (HPA) axis is a key target for the investigation of neurobiological changes induced by chronic stress and violence exposure. The measurement of hair cortisol concentration allows the investigation of long-term HPA activity and its association with victimization. The present study investigated the impact of exposure to polyvictimization in Latin-American children and adolescents on hair cortisol levels. We investigated association among cortisol, mental health problems and victimization. The study included 83 youths (mean age 10.84 years-old) from southern Brazil. We assessed self-reported victimization scores (Juvenile Victimization Questionnaire - JVQ-R2), mental health problems (Child Behavior Checklist - CBCL/6-18), and hair cortisol concentrations for the previous 30 days. The results showed an association between exposure to multiple forms of victimization and higher concentrations of hair cortisol; the results also showed that cortisol levels and mental health problems were associated with the severity of polyvictimization. These findings suggest that preadolescent victimization is associated with hyperactivation of HPA axis and with increased risk of mental health issues.
Beneficial effect of polaprezinc on cardiac function post-myocardial infarction

Background: Polaprezinc is clinically used for the treatment of gastric ulcers. It induces the mobilization of mesenchymal stem cells and the mRNA expression of insulin-like growth factor-1 in vascular endothelial cells in order to protect injured gastric tissue or skin. Methods: The current study population included 50 patients with primary acute myocardial infarction (AMI). After percutaneous coronary intervention, the subjects were randomly divided into 2 groups, namely, the nonpolaprezinc and polaprezinc groups. Peripheral blood and urinary samples were collected in a specific time to analyze zinc concentration, cardiac enzymes, and the levels of the inflammation marker interleukin-6. To evaluate the cardiac function, echocardiography was performed upon admission to the hospital and at 9 months post-AMI. Results: The urine and blood zinc levels of the polaprezinc group were higher compared with those of the non-polaprezinc group at 8 days after percutaneous coronary intervention. The mean interleukin-6/maximal creatine phosphokinase level was significantly reduced in the polaprezinc group (0.024 [0.003–0.066] vs. 0.076 [0.015–0.212], respectively; P = .045). In addition, echocardiography revealed that the ejection fraction of the nonpolaprezinc group was not significantly increased between day 3 and 9 months post-AMI (53 [49–60.8] vs. 59.5 [52–69.3], respectively; P = .015). However, a significant increase was detected in the ejection fraction of the polaprezinc group at the 2 time points (54 [51–57] vs. 62 [55–71], respectively; P < .01). Conclusions: The results of the present study suggest that polaprezinc has an anti-inflammatory effect and improves cardiac function after AMI.