Miracle-dz/UniFAR-FTUs huggingface dataset:
Remote multiple intracranial hemorrhage in multiple metastatic lung adenocarcinoma following decompression of posterior fossa lesion: Unknown cause

Cerebral metastasis can present with hemorrhage. However, multiple hemorrhages in metastatic lesions following surgical decompression of a single lesion are never reported. We report a case of cerebral metastasis from lung cancer that developed multiple hemorrhages in supratentorial metastatic lesions following surgical resection of an infratentorial lesion.
Amélioration de la qualité de vie des patients neuromusculaires insuffisants respiratoires : optimisation de la phonation et de la déglutition

L’atteinte neuromusculaire, responsable notamment d’une degradation des muscles, entraine une insuffisance respiratoire severe. Cette derniere constitue la composante majeure de la maladie, tant en termes de pronostic que de prise en charge. A ce jour, seule la ventilation mecanique permet de compenser l’affection respiratoire. Elle s’impose donc comme indication therapeutique incontournable et son efficacite n’est plus a prouver. En effet, l’utilisation de la ventilation mecanique a permis l’impact de l’atteinte respiratoire tres tot le pronostic vital. En 40 ans, ce traitement a permis d’allonger considerablement l’esperance de vie des malades, passant pour par exemple les myopathies de Duchenne de Boulogne de 15 ans a plus de 30 ans a l’heure actuelle.Aujourd’hui, pour ces personnes dont la duree de vie a pu etre allongee, se pose l’inevitable question de leur Qualite de vie, d’autant plus que cet allongement de vie s’accompagne d’une aggravation de la deficience musculaire et donc des dysfonctions motrices. De plus, il apparait que la ventilation mecanique, si elle assure un confort respiratoire indispensable, accroit considerablement le niveau de dependance des malades et fait emerger chez eux de nouvelles problematiques identitaires, psychosociales ou meme economiques. Il s’avere essentiel d’identifier les consequences de la maladie et du Handicap qu’elle entraine. Il convient ensuite d’analyser l’impact direct de la ventilation mecanique sur la qualite de vie des malades et notamment son effet deletere sur la communication et la deglutition des patients. L’objectif principal de ce travail est de proposer en reponse a notre problematique des alternatives visant a ameliorer la qualite de vie des patients en optimisant les deux grandes fonctions physiologiques que sont la parole et la deglutition
Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy.

The rapidity and duration of the response of non-transferrin-bound iron (NTBPI) to chelation therapy are largely unknown and have important implications for the design of optimal chelation regimens. Methodology was developed to measure simultaneously NTBPI, deferoxamine (DFO), and its major metabolite. NTBPI was present in all but 2 of 28 thalassaemia major (TM) patients who had received conventional subcutaneous DFO the previous night, suggesting a short duration of NTBPI clearance by DFO. The detailed kinetics of NTBPI were therefore studied in response to intravenous DFO at 50 mg/kg/27 h for 48 hours and compared in 17 regularly transfused TM and 8 untransfused thalassaemia intermedia (TI) patients to determine the influence of hypertransfusion and iron overload on NTBPI response. Before DFO infusion, NTBPI was present in all patients and was significantly higher in TI (4.52 +/- 0.53 mumol/L) than TM (2.92 +/- 0.03 mumol/L; P = .03). NTBPI values in TM correlated with transferrin saturation (r = .6, P = .03) but not with serum ferritin. Removal of NTBPI by intravenous DFO is in a biphasic manner. The initial rapid rate constant (alpha) was similar in TI (1.5 hour-1) and TM (1.6 hour-1), but the subsequent beta phase was slower (0.04 hour-1) in TI when compared with TM (0.4 hour-1, P = .002). Detectable NTBPI persisted during the beta phase, particularly in TI, despite an excess of plasma DFO also being present (steady state 8 mumol/L). On cessation of DFO infusion, NTBPI reappearance was rapid; the kinetics also being biphasic. The rapid initial rate constant (alpha = 2.5 hour-1) lasted less than 30 minutes and was approximately equal to the summation of the initial rate constant for removal of DFO (1.8 hour-1) and its major metabolite (0.6 hour-1). This was followed by a slower return to pretreatment levels, usually between 6 and 12 hours, which was faster in TI than in TM. This marked NTBPI lability supports the use of continuous rather than intermittent DFO in high risk patients.
Towards prolonged lifetime for large-scale Information-Centric Sensor Networks

Information-Centric Sensor Networks (ICSNs) are a class of context-aware communication networks that provide an infrastructure for knowledge-based intelligent information service provisioning to anyone, anywhere and at any time. It provides the sensed information to the end-user based on application requirements. To cater to the needs of ICSNs applications, WSNs may need to be deployed on a very large scale. Maintaining network connectivity and longevity in such a large scale deployment of sensor nodes, while catering to the application and service requirements of the ICSN is a challenging task because sensor nodes are very resource constrained in terms of power, communication range and processing capabilities. Hence, we propose the use of cognitive nodes in the underlying WSN, which can help to achieve better management of the sensor network's resources. The cognitive nodes make use of the requested information to learn the dynamic network environment, and make decisions based on the application requirements and current network conditions. Cognitive nodes will use information stored in their knowledge base to help with resource management in the sensor network while catering to the service requirements of the ICSN. The main contribution of this work is to provide a strategy for their deployment in large-scale WSNs used in ICSN applications.
De la pénétration en milieu granulaire

L'objectif de ce travail reside dans la comprehension de la force sur un objet penetrant un milieu granulaire. A partir de mesures de forces sur un cylindre en penetration a vitesse constante, nous avons caracterise cette force qui est independante de la vitesse imposee, proportionnelle au diametre du cylindre et varie non-lineairement avec la taille des grains. En complement, nous avons mesure le champ de vitesse des grains : celui-ci est stationnaire et l'ecoulement est incompressible. On observe une localisation du cisaillement dans une zone proche du cylindre avec une dependance spatiale exponentielle gouvernee par le diametre du cylindre. Un modele hydrodynamique s'appuyant sur la theorie cinetique etendue aux regimes d'ecoulements denses reproduit correctement cette localisation et fournit des lois d'echelles pour la force similaires aux resultats experimentaux. En definissant un nombre de Reynolds granulaire, nous avons montre que ce regime est l'equivalent d'un regime visqueux de Stokes a petit nombre de Reynolds. Il existe une transition vers un autre regime a grand Reynolds ou les profils de vitesses perdent leur symetrie amont-aval et la force change sans doute d'expression. Enfin, le cas de l'impact d'un projectile ou ces deux regimes existent successivement a aussi ete etudie experimentalement et numeriquement. L'existence d'un terme supplementaire de force proportionnelle au carre de la vitesse est sans doute issue du regime a grand Reynolds. Les deux termes donnent lieu a deux temps caracteristiques dont le temps d'arret est fonction et a l'origine d'un temps d'arret plus court pour une vitesse d'impact plus grande.
Phenotypic Effects of Biglycan Deficiency Are Linked to Collagen Fibril Abnormalities, Are Synergized by Decorin Deficiency, and Mimic Ehlers‐Danlos‐Like Changes in Bone and Other Connective Tissues

Decorin (dcn) and biglycan (bgn), two members of the family of small leucine‐rich proteoglycans (SLRPs), are the predominant proteoglycans expressed in skin and bone, respectively. Targeted disruption of the dcn gene results in skin laxity and fragility, whereas disruption of the bgn gene results in reduced skeletal growth and bone mass leading to generalized osteopenia, particularly in older animals. Here, we report that bgn deficiency leads to structural abnormality in collagen fibrils in bone, dermis, and tendon, and to a “subclinical” cutaneous phenotype with thinning of the dermis but without overt skin fragility. A comparative ultrastructural study of different tissues from bgn‐ and dcn‐deficient mice revealed that bgn and dcn deficiency have similar effects on collagen fibril structure in the dermis but not in bone. Ultrastructural and phenotypic analysis of newly generated bgn/dcn double‐knockout (KO) mice revealed that the effects of dcn and bgn deficiency are additive in the dermis and synergistic in bone. Severe skin fragility and marked osteopenia characterize the phenotype of double‐KO animals in which progeroid changes are observed also in the skin. Ultrastructural analysis of bone collagen fibrils in bone of double‐KO mice reveals a complete loss of the basic fibril geometry with the emergence of marked “serrated fibril” morphology. The phenotype of the double‐KO animal mimics directly the rare progeroid variant of human Ehlers‐Danlos syndrome (EDS), in which skin fragility, progeroid changes in the skin (reduced hypodermis), and osteopenia concur as a result of impaired glycosaminoglycan (GAG) linking to bgn and dcn core proteins. Our data show that changes in collagen fibril morphology reminiscent of those occurring in the varied spectrum of human EDS are induced by both bgn deficiency and dcn deficiency in mice. The effects of an individual SLRP deficiency are tissue specific, and the expression of a gross phenotype depends on multiple variables including level of expression of individual SLRPs in different tissues and synergisms between different SLRPs (and likely other macromolecules) in determining matrix structure and functional properties.
3-D image guidance for minimally invasive robotic coronary artery bypass.

BACKGROUND The introduction of a robot-assisted microsurgical system has made endoscopic coronary artery bypass grafting (ECABG) possible. Despite the success of this approach, surgeons still require better visualization tools for pre-surgical planning and intra-operative image guidance. Such visualization tools could, for example, assist in the placement of thoracic ports to acquire optimum access to the target vessels. In this paper we discuss the essential steps toward image-guided completely endoscopic coronary bypass surgery with robot assistance, and we present our preliminary efforts toward the development of a three-dimensional (3-D) virtual cardiac surgical planning platform (VCSP) for ECABG. METHODS Preoperative 3-D images of the thorax acquired with computed tomography and electrocardiogram-gated magnetic resonance imaging are imported into VCSP. Using VCSP, a user may interactively visualize and manipulate the simulated thoracic ports in 3-D within the reconstructed thoracic region. We have also implemented a virtual endoscope to simulate the endoscopic view observed by the surgeon during the operation. Once the port placements for optimal access to the target vessels are determined, the positions of the simulated tools can be recorded and marked on the patient to specify the positions for port incisions. RESULTS A static thorax phantom was used to verify the port placements obtained from VCSP simulations. The angles and the distances between the ports, the endoscope and the markers that were placed on the surface of the phantom were measured, and the results were compared with those obtained from simulation. The physical measured distances and angles agreed with the simulated results with average errors of 4 mm and 2 degrees, respectively. CONCLUSIONS The VCSP image-guided surgical system allows a surgeon to visualize a patient's thorax in a 3-D interactive environment for planning surgical procedures, and to determine the optimum port placement based on preoperative 3-D images. However, during an operation, the positions and orientation of the heart and the coronary arteries are changed from their corresponding locations in the preoperative images due to carbon-dioxide insufflation, lung deflation, and dynamic motions of the beating heart. One of our future goals of this project is the use of mathematical models that correct for these changes so that our system could be applied to intra-operative image guidance.
The influence of document presentation order and number of documents judged on users' judgments of relevance

This article attempts to verify the hypothesis of the document presentation order by an empirical, two-stage experiment. It aims to identify the relationship between number of documents judged and order effect. The results indicate that significant order effect takes place when 15 and 30 documents are presented. Sets with 45 and 60 documents still reveal the order effect. However, subjects are not influenced by order of presentation when the set of documents has 5 and 75 members, respectively.
A CCD clock controller ASIC using novel design techniques integrated in a CMOS 0.8μm SOI high voltage process

An ASIC designed to provide the clock signals to the focal plane CCDs for the SNAP satellite project is presented. A prototype has been implemented in a CMOS 0.8 mum SOI high voltage process in order to accommodate a 20 V output swing. The circuit consists of a main charge pump multiplying the 4 V power supply voltage +/-16 V followed by a controlled current source setting the clock voltage plateaus. A bridge of switches provides the clock voltage transitions at the output. This circuit is designed to operate at room temperature for test purpose and at 140 K, which will be the operating temperature. Novel design techniques used in this chip will be presented in detail along with measurement results obtained on the prototypes.
Euroscepticism Revisited - Regional Interest Representation in Brussels and the Link to Citizen Attitudes towards European Integration

Recent scholarship has suggested that nation-states will gradually fade away in favor of regions and super-regions as the main actors within a European Union characterized by strong regional identities. At the same time, recent developments have shown that citizen support for European integration is essential for any future development of the Union. The puzzle inspiring this paper is the finding that the greatest support for the EU increasingly stems from minority nationalist, or strong identity regions seeking to bypass their central states to achieve their policy goals at the EU level. This paper empirically tests this suggestion, while shedding light on the relationship between the quality of representation of regional interests at the EU level and positive citizen attitudes towards the EU. In particular, it finds two explanations for cross-regional variation in the relationship between Euroscepticism and representation: (1) a cultural explanation, embodied by differences in the nature and quality of representation between regions that are linguistically distinctive and regions that are not; and (2) an institutional explanation, embodied by differences in the nature and quality of representation between regions from federal and non-federal member states. The paper uses an eclectic methodological approach, first utilizing multivariate regression analysis, estimating logistic and ordinal logit models that help explain variation in Euroscepticism at the regional level. The results are then complemented by the findings of indepth elite interviews of regional representatives—more specifically the directors of a selection of the many regional information offices present in Brussels. This paper takes the study of Euroscepticism to a new level, as most previous scholarly work has focused on explanations at the individual or at the member state level. At the same time it strengthens the notion of a growing importance of a “Europe of the regions. ”
Influence of the Melissa officinalis Leaf Extract on Long-Term Memory in Scopolamine Animal Model with Assessment of Mechanism of Action

Melissa officinalis (MO, English: lemon balm, Lamiaceae), one of the oldest and still most popular aromatic medicinal plants, is used in phytomedicine for the prevention and treatment of nervous disturbances. The aim of our study was to assess the effect of subchronic (28-fold) administration of a 50% ethanol extract of MO leaves (200 mg/kg, p.o.) compared with rosmarinic acid (RA, 10 mg/kg, p.o.) and huperzine A (HU, 0.5 mg/kg, p.o.) on behavioral and cognitive responses in scopolamine-induced rats. The results were linked with acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and beta-secretase (BACE-1) mRNA levels and AChE and BuChE activities in the hippocampus and frontal cortex of rats. In our study, MO and HU, but not RA, showed an improvement in long-term memory. The results were in line with mRNA levels, since MO produced a decrease of AChE mRNA level by 52% in the cortex and caused a strong significant inhibition of BACE1 mRNA transcription (64% in the frontal cortex; 50% in the hippocampus). However, the extract produced only an insignificant inhibition of AChE activity in the frontal cortex. The mechanisms of MO action are probably more complicated, since its role as a modulator of beta-secretase activity should be taken into consideration.
Did human speech originate in coordinated vocal music?

In the course of a seven-year study of the vocal sound system of gelada monkeys (Theropithecus gelada) I have discovered several basic functions of gelada sounds which throw some crucial light on possible functions and social contexts of early human speech. Too often, when dealing with these aspects of early human speech, scholars have restricted their speculation to only one function and social situation: the symbolic function of referring to objects in the world and the social situation of transferring such referential information from person to person. During the analysis of 1000 hours of recordings of gelada vocal sequences produced by captive geladas in conditions approaching natural social intercourse, two basic functions of these vocal strings have become obvious through description of the geladas' use of their sounds. These two functions, the poetic and the phatic (see Jakobson 1960), are essentially independent of the symbolicreferential function, however broadly conceived, and of the informationtransfer social situation, and they are crucial for understanding the place of vocal sounds in gelada social life. If the remains of the exclusive expression of these two functions that we find in human choral music really are analogous to gelada coordinated vocal displays, then we should seriously consider them in speculating on early human speech. There is a long tradition in speculation on the functions and social contexts of very early speech of considering only the symbolic-referential function and the information-transfer social situation. Jane Lancaster (1968) expresses this most baldly when she sees 'environmental reference' as the great achievement in the evolution of early human speech. If one thought of speech as merely a collection of words, a large collection of referential signs to be sure, but merely a vocabulary of such
Sequence Elements in Both Subunits of the DNA Fragmentation Factor Are Essential for Its Nuclear Transport*

DNA cleavage is a biochemical hallmark of apoptosis. In humans, apoptotic DNA cleavage is executed by DNA fragmentation factor (DFF) 40. In proliferating cells DFF40 is expressed in the presence of its chaperone and inhibitor DFF45, which results in the formation of the DFF complex. Here, we present a systematic analysis of the nuclear import of the DFF complex. Our in vitro experiments demonstrate that the importin α/β-heterodimer mediates the translocation of the DFF complex from the cytoplasm to the nucleus. Both DFF subunits interact directly with the importin α/β-heterodimer. However, importin α/β binds more tightly to the DFF complex compared with the individual subunits. Additionally, the isolated C-terminal regions of both DFF subunits together bind importin α/β more strongly than the individual C termini. Our results from in vivo studies reveal that the C-terminal regions of both DFF subunits harbor nuclear localization signals. Furthermore, nuclear import of the DFF complex requires the C-terminal regions of both subunits. In more detail, one basic cluster in the C-terminal region of each subunit, DFF40 (RLKRK) and DFF45 (KRAR), is essential for nuclear accumulation of the DFF complex. Based on these findings two alternative models for the interaction of importin α/β with the DFF complex are presented.
A RF TX low insertion loss reconfigurable bandpass filter based on highly linear 65nm CMOS active inductors for cellular applications

This paper presents the design and implementation of a bandpass filter with very low insertion losses (<0.5dB) for cellular transmitters, with 0dBm capabilities. In order to obtain a high integration of the filter with existing fully digital architectures, it has been designed in CMOS 65nm technology. This filter takes full advantage of previously developed highly linear and high Q active inductors in CMOS. We present a design methodology based on filter frequency reconfigurability (1.72.1GHz) while preserving linearity and low insertion losses on this wide frequency range.
Polysulfone/pyrene membranes: a new microwell assay platform for bioapplications.

The use of PSU-Py prepared by click chemistry as a platform in membrane-bottom microwell plates for oxidase and hydrolase/oxidase-based enzyme assays is studied. For the GOx assay, the postulated fluorescence mechanism is based on the consumption of glucose by dissolved oxygen and GOx in the microwell plates covered with the PSU-Py membrane. For the AG-GOx assay, maltose is used as AG substrate and hydrolyzed to glucose which is then oxidized by the GOx activity. It is shown that the PSU-Py membrane acts as a fluorescence indicator of the enzymatic reactions, and both GOx and AG/GOx enzyme assays are successfully applied for glucose, maltose and acorbose analysis in the range 0.125-2.0 × 10(-3) M glucose, 0.05-0.5 × 10(-3) M maltose, and 0.0125-0.1 mg · mL(-1) acorbose, respectively.
Predictors of global functioning and employment 10 years following traumatic brain injury compared with orthopaedic injury

Abstract Objective: The aim of this study was to prospectively investigate predictors of global functioning and employment 10 years following traumatic brain injury (TBI) compared with orthopaedic trauma. Research design: Prospective cohort. Methods: Ninety-seven individuals with complicated mild-to-severe TBI and 91 with traumatic orthopaedic injury were followed-up at 10 years post-injury. Global functioning (GOS-E) and employment status were recorded. Results: Groups did not differ on global functioning or employment status. Post-TBI, shorter PTA and less severe orthopaedic injuries were associated with better global functioning; and shorter PTA and younger age were associated with employment. Following traumatic orthopaedic injury, younger age was associated with employment, but not after excluding individuals no longer in the labour force. Conclusions: In this sample, demographic factors and injury severity contribute to long-term outcomes following TBI, but not orthopaedic trauma. PTA continues to influence outcomes 10 years following TBI. There is ongoing detrimental influence of orthopaedic injuries on global functioning for individuals with TBI, suggesting a potential benefit in greater clinical attention to these injuries. Further understanding of the complex interplay between these predictors and other personal and environmental factors will contribute to improving individualized rehabilitation.