Miracle-dz/UniFAR-FTUs huggingface dataset:
Chromosome 4q31‐34 panic disorder risk locus: Association of neuropeptide Y Y5 receptor variants

There is strong evidence for a genetic contribution to the pathogenesis of panic disorder, with a recent linkage study pointing toward a risk locus on chromosome 4q31‐q34 [Kaabi et al., 2006 ]. Since the neuropeptide Y (NPY) system has been reported to be involved in the pathophysiology of anxiety and in particular panic disorder and the genes coding for NPY Y1, Y2, and Y5 receptors are located in the suggested risk region (4q31‐q32), variants in the NPY, NPY Y1, Y2, and Y5 genes were investigated for association with panic disorder in a sample of 230 German patients with panic disorder and matched healthy controls. A synonymous (Gly‐426‐Gly) NPY Y5 coding variant (rs11946004) as well as haplotypes including rs11946004 and an intronic NPY Y5 variant (rs11724320) were significantly associated with panic disorder (P = 0.027), with the effect originating from the subgroup of female patients (P = 0.030), particularly with concurrent agoraphobia (P = 0.002–0.019). No association was observed for any variants located in the genes coding for NPY, NPY Y1, or Y2. The present results provide preliminary support for an influence of NPY Y5 receptor variants on the etiology of panic disorder in a potentially gender‐specific manner further strengthening the evidence for a risk locus on chromosome 4q31‐q34 in anxiety disorders. However, in order to allow for conclusive evaluation of the present finding and to exclude a false positive result, further studies in larger, independent, preferably family based samples are warranted. © 2007 Wiley‐Liss, Inc.
Foot morphologic characteristics and risk of exercise-related injury.

OBJECTIVE It is widely accepted that persons with flat or high-arched feet are at increased risk of exercise-associated injury, even though this purported association has not been scientifically evaluated. We evaluate the risk of exercise-associated injury among young men with flat, normal, and high-arched feet. DESIGN A prospective study of 246 US Army Infantry trainees followed up over a rigorous 12-week training program. All subjects were evaluated prior to onset of training. Evaluation included photographs of the right, weight-bearing foot that were digitized and utilized to make several measures of arch height. SETTING An army initial entry training center. SUBJECTS All trainees beginning army training on 2 successive weeks were potential volunteers. There were no criteria for exclusion other than declining to participate (n = 3). The subjects were healthy, active young men with a mean age of 20.3 years. OUTCOME MEASURE The occurrence of a lower-extremity musculoskeletal injury resulting in a visit to and a diagnosis by an army physician or physician assistant. Treating physicians and physician assistants were blind to participation status and were not study staff members. RESULTS On univariate analysis, there was an association between arch height and risk of injury using several alternative operational definitions of foot type. The 20% with the flattest feet were at the lowest risk (reference group; odds ratio, 1.0), with adjusted odds ratios for any musculoskeletal injury of 3.0 (P < .05) for the middle 60% group and 6.1 (P < .05) for the highest 20% group. CONCLUSIONS These findings do not support the hypothesis that low-arched individuals are at increased risk of injury, and they have implications for runners, exercise enthusiasts, and clinicians. It may be possible to prevent substantial morbidity among active populations by identifying individuals at high risk and advising alternate activities.
Using Six Hats' Strategy In Enhancing Supervisory Skills Of Efl Counsellors And Their Intellectual Flexibility

T he main aim of the current study was to investigate the effect of the six hats' strategy on enhancing supervisory skills of English counsellors and their intellectual flexibility. The study was conducted in Beni Suef educational district. Twenty five EFL supervisors acting on as one study group were trained on supervisory skills using six hats' strategy . Statistical analysis of the data revealed that there were statistically significant differences between the mean scores of the experimental group students in the pre and post administration in the supervisory skills' situational test as well as in the intellectual flexibility' scale in favor of the post administration. The magnitude effect was big; thereby proving the effect of the six hats' strategy.
Probiotics for the management of neonatal hyperbilirubinemia: a systematic review of randomized controlled trials

Abstract Background: Neonatal jaundice requiring phototherapy is associated with significant socioeconomic burden including hospital readmission, prolonged hospital stay, and separation of the baby from mother. Objectives: To assess the efficacy and safety of probiotics in reducing the need for phototherapy and its duration in neonatal hyperbilirubinemia. Methods: A systematic review of randomized controlled trials (RCTs) of probiotic supplementation for prevention or treatment of jaundice in neonates (any gestation or weight) using the Cochrane methodology. Primary outcome was the duration of phototherapy. Secondary outcomes included incidence of jaundice, total serum bilirubin (TSB) level at 24, 48, 72, 96 h, and day 7, duration of hospital stay, and adverse effects (e.g. probiotic sepsis). Results were summarized as per GRADE guidelines. Results: Nine RCTs (prophylactic: six trials, N = 1761; therapeutic: three trials, N = 279) with low to high risk of bias were included. Meta-analysis (random-effects model) showed probiotic supplementation reduced duration of phototherapy [N = 415, mean difference (MD): −11.80 (−17.47, −6.13); p < . 0001; level of evidence (LOE): low]. TSB was significantly reduced at 96 h [MD: −1.74 (−2.92, −0.57); p = . 004] and 7 d [MD: −1.71 (−2.25, −1.17); p < . 00001; LOE: low] after probiotic treatment. Prophylactic probiotics did not reduce the incidence of jaundice significantly [N = 1582, relative risk (RR): 0.56 (0.25, 1.27); p = . 16; LOE: low]. There were no probiotic-related adverse effects. Conclusion: Limited low-quality evidence indicates that probiotic supplementation may reduce the duration of phototherapy in neonates with jaundice. Routine use of probiotics to prevent or treat neonatal jaundice cannot be recommended. Large well-designed trials are essential to confirm these findings.
Simultaneous amino acid substitutions at antigenic sites drive influenza A hemagglutinin evolution

The HA1 domain of HA, the major antigenic protein of influenza A viruses, contains all of the antigenic sites of HA and is under continual immune-driven selection. To resolve controversies on whether only a few or many residue sites of HA1 have undergone positive selection, whether positive selection at HA1 is continual or punctuated, and whether antigenic change is punctuated, we introduce an approach to analyze 2,248 HA1 sequences collected from 1968 to 2005. We identify 95 substitutions at 63 sites from 1968 to 2005 and show that each substitution occurred very rapidly. The rapid substitution and the fact that 57 of the 63 sites are antigenic sites indicate that hitchhiking plays a minor role and that most of these sites, many more than previously found, have undergone positive selection. Strikingly, 88 of the 95 substitutions occurred in groups, and multiple mutations at antigenic sites sped up the fixation process. Our results suggest that positive selection has been ongoing most of the time, not sporadic, and that multiple mutations at antigenic sites cumulatively enhance antigenic drift, indicating that antigenic change is less punctuated than recently proposed.
Zinc tolerance, uptake, and accumulation in the wetland plants Eriophorum angustifolium, Juncus effusus, and Juncus articulatus

Metal tolerance in plants is thought to evolve following exposure to elevated metal levels in the soil. However, there are examples of species that appear to have developed constitutive metal tolerance without apparent exposure to metals. In previous studies, populations from contaminated and non-contaminated sites of the wetland plants Typha latifolia, Phragmites australis, and Glyceria fluitans were found to be equally tolerant to high concentrations of metals. In this study, zinc uptake and growth responses of populations of Eriophorum angustifolium, Juncus effusus, and Juncus articulatus from zinc-contaminated and non-contaminated sites were compared as part of a research project investigating metal tolerance in wetland plants. The populations were grown hydroponically in zinc-amended nutrient solutions. Juncus articulatus could not grow in the presence of elevated zinc concentrations, and no growth differences between populations were observed. Both populations of Juncus effusus from contaminated and non-contaminated sites grew well in moderately elevated zinc concentrations, but growth was inhibited at the higher treatment levels. Growth of Eriophorum angustifolium was inhibited less than growth of Juncus effusus at the higher zinc treatment levels. Both populations were able to tolerate concentrations of zinc of up to 100 μmol L−1. The findings for Juncus effusus and Eriophorum angustifolium support the theory that wetland plants tend to be tolerant to exposure to high levels of metals, but the results for Juncus articulatus suggest that this is not a general rule.
Protein kinase activity associated with the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10)

The large subunit of the herpes simplex virus type 2 (HSV-2) ribonucleotide reductase (RR1) is demonstrated to possess serine/threonine-specific kinase activity. Computer-assisted sequence analysis identified regions within the amino terminus of ICP10 that are homologous to the catalytic domain of known protein kinases (PKs). An in vitro kinase assay confirmed the ability of ICP10, immunoprecipitated from either HSV-2-infected cells or from cells transfected with an ICP10 expression vector, to autophosphorylate and transphosphorylate exogenous substrates in the presence of ATP and Mg2+. The HSV-1 RR1 was shown to be negative for PK activity under these conditions. PK activity was localized to a 57-kDa amino-terminal region within ICP10 that lacked RR activity.
Hypermethylation of DAPK1 is an independent prognostic factor predicting survival in diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. Improvements in overall survival have been observed with the introduction of rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), however, prognostic markers are still needed. Methylation of the death associated protein kinase (DAPK or DAPK1) gene and TP53 mutations are likely to have prognostic value in DLBCL. We have assessed TP53 mutations and allelic DAPK1 methylation patterns in a cohort of 119 DLBCL patients uniformly treated with R-CHOP-like regimens. We found that DAPK1 promoter methylation was associated with shorter overall survival (p=0.017) and disease-specific survival (p=0.023). In multivariate analyses DAPK1 methylation remained as an independent prognostic factor predicting disease-specific survival (p=0.038). When only considering individuals heterozygous for the rs13300553 SNP monoallelic methylation of the A-allele was associated with shorter overall- and disease-specific survival (p<0.001). Patients carrying both DAPK1 methylation and a TP53 mutation had an inferior survival compared to patients carrying only one of these molecular alterations, however, this was borderline statistically significant. Allele-specific DAPK1 methylation patterns were also studied in a cohort of 67 multiple myeloma patients, and all of the methylated multiple myeloma samples heterozygous for the rs13300553 SNP were methylated on both alleles.
The function of ABCB transporters in auxin transport

Plant ATP-binding cassette (ABC) transporters consist of largest family members among many other membrane transporters and have been implicated in various functions such as detoxification, disease resistance and transport of diverse substrates. Of the ABC-B/multi-drug resistance/P-glycoprotein (ABCB/MDR/PGP) subfamily, at least five members have been reported to mediate cellular transport of auxin or auxin derivatives. Although single mutant phenotypes of these genes are milder than PIN-FORMED (PIN) mutants, those ABCBs significantly contribute for the directional auxin movement in the tissue-level auxin-transporting assay. Uniformly localized ABCB proteins in the plasma membrane (PM) are generaly found in different plant species and stably retained regardless of internal and external signals. This implies that these ABCB proteins may play as basal auxin transporters.
Comparison of Haplotype Inference Methods Using Genotypic Data from Unrelated Individuals

Objective: Haplotypes are gaining popularity in studies of human genetics because they contain more information than does a single gene locus. However, current high-throughput genotyping techniques cannot produce haplotype information. Several statistical methods have recently been proposed to infer haplotypes based on unphased genotypes at several loci. The accuracy, efficiency, and computational time of these methods have been under intense scrutiny. In this report, our aim was to evaluate haplotype inference methods for genotypic data from unrelated individuals. Methods: We compared the performance of three haplotype inference methods that are currently in use – HAPLOTYPER, hap, and PHASE – by applying them to a large data set from unrelated individuals with known haplotypes. We also applied these methods to coalescent-based simulation studies using both constant size and exponential growth models. The performance of these methods, along with that of the expectation-maximization algorithm, was further compared in the context of an association study. Results: While the algorithm implemented in the software PHASE was found to be the most accurate in both real and simulated data comparisons, all four methods produced good results in the association study.
Spontaneous miniature outward currents in mechanically dissociated rat Meynert neurons

1 Spontaneous miniature outward currents (SMOCs) were observed in mechanically dissociated rat Meynert neurons using nystatin perforated patch recordings under voltage‐clamp conditions. 2 SMOCs were blocked by apamin, a selective blocker of small conductance Ca2+‐activated K+ (SK) channels, but not by blockers for other types of Ca2+‐activated K+ channel. 3 Ryanodine (10‐100 μm) reduced both the amplitude and frequency of SMOCs. Caffeine (1 mm) increased the SMOC frequency. Blockers of the sarco/endoplasmic reticulum Ca2+‐ATPase completely abolished SMOCs, indicating a requirement for functioning sarco/endoplasmic reticulum (SR/ER) Ca2+ stores. 4 Both Cd2+‐containing and Ca2+‐free solutions partially inhibited SMOC frequency, a result which suggests that Ca2+ influx contributes to, but is not essential for, SMOC generation. 5 Thus, SMOCs are SK currents linked to ryanodine‐ and caffeine‐sensitive SR/ER Ca2+ stores, and are only indirectly influenced by extracellular Ca2+ influx. The development of this new, minimally invasive mechanical dissociation method has revealed that SMOCs are common in native CNS neurons.
An axiomatics for nonstandard set theory, based on von Neumann–Bernays–Gödel Theory

Abstract We present an axiomatic framework for nonstandard analysis—the Nonstandard Class Theory (NCT) which extends von Neumann–Gödel–Bernays Set Theory (NBG) by adding a unary predicate symbol St to the language of NBG (St(X) means that the class X is standard) and axioms—related to it—analogs of Nelson's idealization, standardization and transfer principles. Those principles are formulated as axioms, rather than axiom schemes, so that NCT is finitely axiomatizable. NCT can be considered as a theory of definable classes of Bounded Set Theory by V. Kanovei and M. Reeken. In many aspects NCT resembles the Alternative Set Theory by P. Vopenka. For example there exist semisets (proper subclasses of sets) in NCT and it can be proved that a set has a standard finite cardinality iff it does not contain any proper subsemiset. Semisets can be considered as external classes in NCT. Thus the saturation principle can be formalized in NCT.
Big data modeling framework for crowdfunding cloud

The crowdfunding market is experiencing rapid growth, with more than 1,200 active platforms in 2015. These platforms generate a huge amount of open financial data in real time. Data management is critical for the success of crowdfunding ecosystems, which include platform providers, fund providers, and fund seekers. This poses a unique research challenge as the data management field has not studied how to manage big data in the cloud computing scenario. In this paper we develop a framework for managing big data from multiple crowdfunding platforms that will be serviced by one cloud computing system. Our research objective is to propose a novel data management paradigm that deals with diverse data models that evolve constantly. Specifically, we (1) outline a set of common features for typical crowdfunding models, (2) describe typical evolutionary data model changes, and (3) present a novel data modelling approach that deals with data diversity and evolution efficiently in one cloud. We also discuss several research challenges in managing big data from multiple industries under one cloud.
Analyzing Organizational Commitment and the Effect on Job Turnover in Nurse Residents

A consistent definition of competence in nursing is needed considering the significance to nursing professional development. The author bridges the gap between previous concept analyses of competence by creating an overarching model, while discussing the relationship to quality of nursing care. Significance of competence and quality care to nursing professional development is explored. The author concludes with implications for nursing professional development practice and research, while highlighting the relevance to professional nursing.
More than meets the eye: on the importance of retail cigarette merchandising

Point-of-sale activity is important enough to get the attention of the senior management of transnational firms and to be the subject of sophisticated research aimed to realise “intrusive visibility” better through creative design, command attention and convey brand imagery. The result of this is the promotional “positioning” of products, and the creation of both friendly familiarity and perceived popularity. The intended results include increased sales of cigarettes as a product or “category growth”.
Reduced hippocampal LTP in mice lacking a presynaptic protein: complexin II

The SNAP receptor (SNARE) complex is a core complex specialized for synaptic vesicle exocytosis, and the binding of SNAPs to the complex is an essential step for neurotransmitter release. Complexin I and II have been identified as SNARE‐complex‐associated proteins. Importantly, complexins compete with α‐SNAP for binding to the complex, suggesting that complexins may modulate neurotransmitter release process. To examine this possibility and to understand the physiological function of complexins, we generated complexin II knockout mice. The complexin‐II‐deficient mice (–/–) were viable and fertile, and appeared normal. Electrophysiological recordings in the mutant hippocampus showed that ordinary synaptic transmission and paired‐pulse facilitation, a form of short‐term synaptic plasticity, were normal. However, long‐term potentiation (LTP) in both CA1 and CA3 regions was impaired, suggesting that complexin II may not be essential for synaptic vesicle exocytosis, but it does have a role in the establishment of hippocampal LTP.
The sentinel node in breast cancer--a multicenter validation study.

BACKGROUND Pilot studies indicate that probe-guided resection of radioactive sentinel nodes (the first nodes that receive drainage from tumors) can identify regional metastases in patients with breast cancer. To confirm this finding, we conducted a multicenter study of the method as used by 11 surgeons in a variety of practice settings. METHODS We enrolled 443 patients with breast cancer. The technique involved the injection of 4 ml of technetium-99m sulfur colloid (1 mCi [37 MBq]) into the breast around the tumor or biopsy cavity. "Hot spots" representing underlying sentinel nodes were identified with a gamma probe. Sentinel nodes subjacent to hot spots were removed. All patients underwent a complete axillary lymphadenectomy. RESULTS The overall rate of identification of hot spots was 93 percent (in 413 of 443 patients). The pathological status of the sentinel nodes was compared with that of the remaining axillary nodes. The accuracy of the sentinel nodes with respect to the positive or negative status of the axillary nodes was 97 percent (392 of 405); the specificity of the method was 100 percent, the positive predictive value was 100 percent, the negative predictive value was 96 percent (291 of 304), and the sensitivity was 89 percent (101 of 114). The sentinel nodes were outside the axilla in 8 percent of cases and outside of level 1 nodes in 11 percent of cases. Three percent of positive sentinel nodes were in nonaxillary locations. CONCLUSIONS Biopsy of sentinel nodes can predict the presence or absence of axillary-node metastases in patients with breast cancer. However, the procedure can be technically challenging, and the success rate varies according to the surgeon and the characteristics of the patient.
THE MEDIATION INFLUENCE OF VALUE RELEVANCE OF ACCOUNTING INFORMATION, INVESTMENT DECISION AND DIVIDEND POLICY ON THE RELATIONSHIP BETWEEN PROFITABILITY AND THE COMPANY’S VALUE

This study aimed to analyze the influence of profitability on the company's value, and determine whether this influence intervenes the value relevance of accounting information, investment opportunities and dividend policy, assuming that investors act rationally so that the fundamental aspects of the financial statements become major factor in the shares investment decision. The contribution of this research is to provide input to the management about the importance of maintaining and improving performance in order to give satisfaction to investors and provide expectations for the return on investment which can ultimately increase the company’s value. This study design is causality with the unit of analysis is the samples taken by purposive sampling technique on a population of listed companies on the IDX Kompas 100 index from 2011 - 2014. The analysis technique used is Path Analysis. The results from this study are: 1. Profitability has significant and positive influence on the company’s value; 2. Profitability has no significant and positive influence on the value relevance of accounting information; 3. Profitability has negative and significant influence on investment opportunities; 4. Profitability has significant and positive influence on the dividend policy; 5. The value relevance of accounting information has significant and negative influence on the company’s value; 6. The investment opportunities have no significant and positive influence on company’s value; 7. Dividend policy has no significant and positive influence on company’s value; 8. The value relevance of accounting information, investment opportunities and dividend policy have not been able to mediate the influence of profitability on company’s value.