Miracle-dz/UniFAR-FTUs huggingface dataset:
Overexpression of forkhead box M1 and urokinase-type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis

Forkhead box M1 (FOXM1) and urokinase-type plasminogen activator (uPA) are overexpressed and associated with the pathogenesis of multiple types of human malignancy. The aims of the present study were to investigate FOXM1 and uPA expression levels in human gastric cancer using tissue microarray techniques; determining their association with clinicopathological characteristics as well as their prognostic value. Tissue microarray blocks, comprising 436 gastric cancer cases and 92 non-cancerous adjacent normal gastric tissues, were analyzed for FOXM1 and uPA protein expression levels using immunohistochemistry. The results were analyzed statistically in association with various clinicopathological characteristics and overall survival rates. FOXM1 and uPA were detected in 78.67 (343/436) and 83.26% (363/436) of cancer samples, respectively. FOXM1 and uPA were not expressed in the 92 normal gastric tissue samples. In gastric cancer, FOXM1 and uPA levels were associated with tumor size, depth of invasion, tumor-node-metastasis (TNM) stage, lymph node metastasis, vessel invasion and distant metastases. The overall survival rate was significantly decreased in patients expressing FOXM1 and uPA compared with FOXM1- and uPA-negative patients. Coxs multivariate analysis revealed that age, depth of invasion and expression levels of FOXM1 and uPA are independent predictors of survival in patients with gastric cancer. These results indicated that increased FOXM1 and uPA expression levels are associated with the invasive and metastatic processes in human gastric cancer, and inversely associated with patient prognosis. Therefore, FOXM1 and uPA may serve as novel prognostic markers independent of, but supplementing, the TNM staging system.
Vascularization of cutaneous melanoma involves vessel co‐option and has clinical significance

This study was undertaken to determine the role and the fate of the peritumoural vascular plexus during the vascularization of human malignant melanoma (hMM) and in an appropriate murine melanoma model system. The prognostic significance of the vascularity of different tumour areas was also evaluated. Despite morphometry revealing several‐fold higher microvessel densities (MVDs) in the peritumoural tissue than at the centre of the tumour, the development of visceral metastases of hMM was exclusively correlated with the MVD of the tumour centre. Furthermore, the 5‐year survival of the patient group with low tumour centre MVD (<30/mm2, n=29) was 100%, compared to 1/16 patients alive with high tumour centre MVD (>30/mm2, n=16). Morphometric analysis and three‐dimensional reconstruction of vessel networks of both human and murine melanomas showed clearly that the peritumoural vascular plexus present at the melanoma base is continuously being incorporated into the growing tumour mass. Once vessels become incorporated, sprouting ceases and the proliferating endothelial cells (EC) take part only in vessel dilatation. Moreover, the immunohistochemical and ultrastructural characterization of microvessels demonstrated that the pericyte coverage of endothelial tubes was complete in all of the investigated areas, in both human and murine melanomas. Copyright © 2002 John Wiley & Sons, Ltd.
Piezoresistivity in vapor-deposited diamond films

We report the observation of a very large piezoresistive effect in both polycrystalline and homoepitaxial chemical‐vapor‐deposited diamond films. The gauge factor for polycrystalline p‐type diamond at 500 microstrains was found to be only 6 at room ambient, but increased rapidly with temperature, exceeding that of polycrystalline silicon (30) at 35 °C, and that of single‐crystal Si (120) at 50 °C. For strain and current flow in the [100] direction, the gauge factor of a (100)‐oriented homoepitaxial diamond film was found to be at least 550 at room temperature. Although the origins and unexpected temperature dependence of piezoresistive effect in diamond are not yet understood, these findings may suggest diamond‐based sensors with performance significantly superior to that of their Si counterparts.
Selected Cytokine Profiles during Remission in Bipolar Patients

Objectives: The aim of the study was to examine the cytokine status in bipolar patients during immediate remission after acute episodes of mania or depression and in patients with sustained (≥6 months) remission, compared with healthy controls. Methods: The study was performed on 121 bipolar patients, of whom 35 were in immediate remission after mania, 41 were in immediate remission after depression, and 45 were in >6-month remission on lithium monotherapy or lithium combined with other drugs. The control group consisted of 78 healthy individuals without any history of psychiatric or immunological illnesses. Serum concentrations of IL-1β, IL-2, IL-6, IL-10, TNF-α and IFN-γ were determined using the Human Th1/Th2 Cytometric Bead Array method. Results: The concentration of IL-10 was higher in patients in remission after mania and the concentration of IFN-γ was higher in those in remission after depression than in healthy controls. On the other hand, cytokine concentrations in patients with sustained remission were not different from those of healthy subjects. Conclusions: The results obtained in this study show that sustained remission in bipolar patients achieved mostly by lithium maintenance brings the cytokine status to a level similar to healthy control subjects.
Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

OBJECTIVE To present nationally representative data on the lifetime prevalence and comorbidity of 8 specific drug use disorders, separately for abuse and dependence, and mood and anxiety disorders. METHOD Data come from a representative sample (N=43,093) of the United States civilian, noninstitutional population 18 years and older. Diagnoses of mood, anxiety, and drug use disorders were based upon face-to-face personal interviews using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version (AUDADIS-IV). RESULTS Associations between specific mood and anxiety disorders and specific drug use disorders were virtually all positive and statistically significant (p<.05). In general, associations were greater for dependence than abuse, greater for mood than anxiety disorders, and in some instances stronger among women than men (p<.05). Large odds ratios also were observed for individuals with comorbid mood and anxiety disorders. CONCLUSION The comorbidity between specific mood and anxiety disorders and specific drug use disorders is pervasive in the U.S. population. Findings suggest that comorbid psychiatric disorders may increase the risk of greater involvement in more serious illicit drug use disorders and that the greater comorbidity between mood and anxiety and drug use disorders among women may reflect greater deviance and psychopathology among drug-using women than men. Findings also suggest that drug abuse prevention and intervention efforts should address other psychiatric conditions. Further, definitions of drug use disorder phenotypes should give careful consideration to other psychiatric conditions as meaningful characteristics of case heterogeneity.
Type-Specific Detection of Human Papillomaviruses in a Routine Laboratory Setting – Improved Sensitivity and Specificity of PCR and Sequence Analysis Compared to Direct Hybridisation

Abstract Human papillomaviruses (HPV) are known to cause cervical dysplasia and cervical carcinoma. We used a 3-step PCR protocol that allows rapid type-specific HPV testing in a routine laboratory setting: HPV-16-positive samples were determined using a specific Light-Cycler PCR; HPV-16-negative samples were amplified by nested PCR and typed by sequence analysis. During a period of 7 months, 1275 PCR-based HPV tests were performed. Of the 1275 samples, 829 samples tested negative for HPV and 446 tested positive, including 124 positives found in the initial HPV-16-specific Light-Cycler assay. Sequence analysis of 132 samples detected 18 HPV types that are not included in the widely used Hybrid Capture II assay. For comparison, the first 100 cervical specimens were tested in parallel using PCR and direct hybridisation (Hybrid Capture II assay). PCR detected HPV DNA in 23 samples that tested negative in the Hybrid Capture assay. Four out of 37 samples that tested positive for HPV in the Hybrid Capture test may be false positives, because sequence analysis detected HPV types not included in the probe mixtures. As rare and novel HPV types may also confer an oncogenic risk, highly sensitive and specific PCR assays will help in understanding cervical HPV infection and cervical cancer of unknown causes.
Loss Analysis of Interior Permanent Magnet Motors Considering Carrier Harmonics and Magnet Eddy Currents Using 3-D FEM

In this paper, we investigate losses of interior permanent magnet motors driven by PWM inverters using the 3-D finite element analysis, which can estimate the eddy current loss in the permanent magnet accurately. The calculated losses are compared with the measured results and the theoretical solution to verify the validity of the analysis. The method to decompose the electromagnetic field distribution into time-harmonic components is introduced in order to investigate the effects of the harmonic fields separately and to specify the main loss factors. The variation of the magnet eddy current loss due to the division of the magnet is also investigated. It is clarified that the eddy current loss in the permanent magnet is mainly produced by the carrier harmonics of the inverter and that the axial length of the divided magnet should be smaller than the skin depth of the eddy currents produced by the major harmonics for the loss reduction.
Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

Interleukin-2 (IL-2), which is a growth factor for T lymphocytes, can also sometimes be inhibitory. Thus, the proliferation of CD8+ T cells in vivo is increased after the injection of a monoclonal antibody that is specific for IL-2 (IL-2 mAb), perhaps reflecting the removal of IL-2–dependent CD4+ T regulatory cells (T regs). Instead, we show here that IL-2 mAb augments the proliferation of CD8+ cells in mice simply by increasing the biological activity of preexisting IL-2 through the formation of immune complexes. When coupled with recombinant IL-2, some IL-2/IL-2 mAb complexes cause massive (>100-fold) expansion of CD8+ cells in vivo, whereas others selectively stimulate CD4+ T regs. Thus, different cytokine-antibody complexes can be used to selectively boost or inhibit the immune response.
Occupational Injuries Due to Violence

Each year in the United States, an estimated 800 to 1,400 people are murdered at work, and an unknown number of nonfatal injuries due to workplace violence oocur. Based on Ohio's workers' compensation claims from 1983 through 1985, police officers, gasoline service station employees, employees of the real estate industry, and hotel/motel employees were found to be at the highest risk for occupational violent crime (OVC) injury and death. Grocery store employees, specifically those working in convenience food stores, and employees of the real estate industry had the most reported rapes. Four previously unidentified industries at increased risk of employee victimization were described. Identification of industries and occupations at high risk for crime victimization provides the opportunity to focus preventive strategies to promote employee safety and security in the workplace.
Transitory Assembly Scheduling based on deterministic Correlation Functions

We present a deterministic scheduling approach for flexible assembly lines and robotic workcells based on n-dimensional collision functions. By collision functions, the different process plans which include parallel robot operations are correlated and coordinated. Feasible schedules only exist for zero correlation. Coordination parameters are the release time intervals for each individual process. The scheduling algorithms rest upon an extended Gantt chart representation for the process plans which model the exclusive use of space resources.
SARA: Sandwiched attestation through remote agents for cluster-based wireless sensor networks

Cluster-based wireless sensor networks have advantages of scalability and efficient communication. However, a major security risk to cluster heads is a malicious code injection attack through which an adversary can completely control a cluster network to deliver fake data and obtain private data. Memory attestation scheme is an effective mechanism for attesting the firmware integrity of an embedded device. Unfortunately, existing hardware-based remote attestation scheme relying on a trusted platform module incurs a considerable storage overhead to cluster heads. Therefore, this article proposes a lightweight hardware-based remote attestation scheme that comprises two remote attestation protocols. A lightweight hardware security module without executing any complicated cryptographic computation is employed and can substantially reduce the development cost and energy consumption compared with the trusted platform module. In the proposed scheme, a base station can attest each individual cluster head while all cluster nodes can simultaneously attest their cluster head in regular intervals. Performance analysis indicates that the storage requirement for cluster heads is independent of the number of attestation sessions. Furthermore, the computational cost of cluster nodes for the proposed scheme is comparable to that of the trusted platform module–based scheme. The proposed scheme is particularly suitable for long-term applications based on lightweight cluster heads.
Influence of Tinnitus on Auditory Spectral and Temporal Resolution and Speech Perception in Tinnitus Patients

Although cochlear damage is believed to trigger the perception of tinnitus in the central auditory system, its pathophysiological mechanism is still unclear. We aimed to investigate the pathophysiology of tinnitus using psychoacoustic assessments of auditory spectral and temporal resolution and speech perception in noise. Human subjects with tinnitus and symmetric hearing thresholds were divided into three groups: nine unilateral tinnitus subjects with normal hearing thresholds (Group 1), 12 unilateral tinnitus subjects with hearing loss (HL; Group 2), and nine bilateral tinnitus subjects with HL. Fifteen normal-hearing subjects without tinnitus were also tested as a control group. Four different tests were administered: (1) the spectral-ripple discrimination (SRD) test, (2) the temporal modulation detection (TMD) test, (3) the Schroeder-phase discrimination (SPD) test, and (4) the speech recognition threshold (SRT) in noise test. There were no significant differences in SRD, TMD, and SPD between the tinnitus-affected ears (TEs) and non-tinnitus ears (NTEs) in Groups 1 and 2 (p > 0.05). In contrast, the TEs showed poorer SRTs than the NTEs in these two subject groups (p = 0.022 and 0.049). No inferiority of spectral/temporal resolution in TEs compared with NTEs suggests that there may be no more outer hair cell (OHC) damage on the tinnitus side given that damaged OHCs are associated with broadening the auditory filters. The decoupling of the SRT results from the spectral/temporal resolution data could imply that the occurrence of tinnitus does not depend upon the degree of damage to the OHCs, but rather upon different plastic changes in the central auditory system after cochlear damage. SIGNIFICANCE STATEMENT We can easily find unilateral tinnitus patients who have symmetric hearing thresholds. Our research question was what kind of difference would be responsible for the tinnitus in the tinnitus-affected ears but not in the non-tinnitus ears of subjects with symmetric hearing thresholds. The answer to this fundamental question could help us to understand the pathophysiology of tinnitus. We evaluated the potential influence of tinnitus upon the subjects' auditory spectral and temporal resolution and speech perception in noise by comparing these psychoacoustic performances between tinnitus-affected ears and non-tinnitus ears in the same subjects.
Torque and Field Currents Peculiarities Under Different Induction Machine Troubles

Motor current signature analysis (MCSA) is a method usually adopted to detect troubles in induction machines. However misunderstandings can be found about the mechanisms linking the anomalies to the current spectrum components. To improve the comprehension of these mechanisms a rotor flux observer to compute field current and torque current is proposed. Input currents and voltages and mechanical speed are the signals taken into account for the computation. The effects of mechanical unbalance and of mixed eccentricity and then the effect of a rotor asymmetry are considered. For the experiments a machine presenting an intrinsic rotor asymmetry and an intrinsic mixed eccentricity is utilized. A mechanical unbalance and an artificial increment of mixed eccentricity are introduced. The peculiarities of the considered variables due to the different troubles and their dependence on machine load are evidenced.
Structural Proteins of Vesicular Stomatitis Viruses

Three major and three minor structural proteins were identified by polyacrylamide gel electrophoresis of purified infectious virions of the Indiana serotype of vesicular stomatitis (VS) virus disrupted with acetic acid, 0.5 m urea, sodium dodecyl sulfate (SDS), and 2-mercaptoethanol. Molecular weights of the six virion proteins were estimated by comparative electrophoretic migration of known marker proteins in the presence of SDS. The following values were obtained: major proteins P6 ≅ 34,500, P5 ≅ 59,500, and P4 ≅ 81,500; minor proteins P3 ≅ 140,000, P2 ≅ 186,000, and P1 ≅ 275,000. P1 did not disaggregate in 8 m urea, but P2 and P3 did. The possibility that P1 is an uncleaved large polypeptide chain could not be ruled out. Six identical protein components were dissociated from Indiana VS virions grown in chick and mouse cells; no cellular proteins could be detected in purified virions. Of six proteins identified in virions of the New Jersey serotype, only the smallest protein (P6) could be distinguished from any of the six proteins of the Indiana serotype on the basis of migration in SDS gels. The defective T particles of Indiana VS virus contained the same six proteins in essentially the same proportions as those of the infectious B virions. Only P6 and P5 could be cleanly separated by preparative gel electrophoresis.
Factor Graph Aided Multiple-Symbol Differential Detection in the Broadcasting Phase of a Network Coding Based UWB Relay System

A factor-graph-aided multiple-symbol differential detection (FG-MSDD) is proposed and its performance is analyzed and evaluated in the broadcasting phase (i.e., the downlink phase) of an ultra-wideband (UWB) two-way relay system (TWRS). In the downlink of the TWRS, the relay is transmitting network-coded information to the sources, and each source node aims to calculate a posteriori probabilities (APPs) of the information symbols from the relay node. A sampling method based on the modified autocorrelation receiver is proposed for FG-MSDD, which has a trellis structure. The trellis can be decomposed into multiple subtrellises depending on the FG factorization. Then, a methodology for APPs is derived when the forward-and-backward message passing is performed on the subtrellises. The main advantage of FG-MSDD is that it exploits soft information accurately with the aid of the bidirectional message passing. In addition, the proposed FG-MSDD, in conjunction with any soft-input soft-output (SISO) decoding scheme, is capable of obtaining an iterative detection algorithm. Various performance evaluation results obtained by means of computer simulations have verified that the proposed algorithm improves detection performance for the noncoherent UWB TWRS.
Exploring Urban Tree Site Planting Selection in Mexico City through Association Rules

In this paper we present an exploration of association rules determine planting sites considering urban treeâs characteristics. In first step itemsets and rules are generated using the unsupervised algorithm Apriori. They are rapidly characterized in terms of tree planting sites. In a second step planting sites are fixed as target values to establish rules (a supervised version of the a priori algorithm). An original approach is also presented and validated for the prediction of the planting site of the species.
Defective urinary concentrating ability due to a complete deficiency of aquaporin-1.

Aquaporin-1, the archetypal water-channel protein,1 was initially identified in red cells and renal proximal tubular epithelium.2 The gene for aquaporin-1 (AQP1) on chromosome 7 colocalizes with the Colton blood-group antigen,3,4 and the Colton blood-group antigen polymorphism was identified as a substitution of a single amino acid in an extracellular domain of aquaporin-1.5 The International Blood Group Reference Laboratory has confirmed the existence of only six kindreds who lack the Colton blood group. Members of three of these kindreds were found to be homozygous for different mutations in the AQP1 gene, and their red-cell membranes had a complete .
New Modulation Techniques for a Leakage Current Reduction and a Neutral-Point Voltage Balance in Transformerless Photovoltaic Systems Using a Three-Level Inverter

Transformerless topologies of many topologies are widely used in photovoltaic (PV) systems because these topologies have many advantages in terms of the weight, size, and efficiency. A three-level inverter has an outstanding performance and is advantageous in the switching device selection than a two-level inverter. In the transformerless PV systems using the three-level inverter, the PV systems should suffer from the leakage current and generate the neutral-point voltage unbalance. To solve two problems, this paper proposes modulation techniques to reduce the leakage current and balance the dc-link voltages. The cause of the leakage current in the three-level inverter is analyzed. The proposed technique LMZVM using the large, medium, and zero vectors reduces the common mode voltage that causes the leakage current than that of the conventional PWM. Moreover, the proposed technique LMSVM using the large, medium, and small vectors balances the dc-link voltages with reduced CMV as the same in LMZVM. The effectiveness of the proposed techniques is verified by comparing its results with those of the convectional PWM. The results are obtained through simulations and experiments.
Integration of Health Promotion into Nursing Practice: A Case Study in Pakistan

The purpose of this study was to understand the concept of health promotion and perceptions related to the integration of health promotion in nursing practice in Pakistan. The study utilized the qualitative single case study approach to explore and describe the concept of health promotion, its significance and ways to integrate health promotion strategies in nursing practice. The data were collected from three different sources; focus group discussion among final year Post-RN BScN students, key informant interviews of practicing nurses, faculty, and MScN students, as well as a document review of the Post-RN BScN curriculum. Data analysis included a content and thematic analysis, yielding four major themes—”Health Promotion as Diverse”, “Health Promotion as Necessary”, “Health Promotion as Nursing Role”, and “Health Promotion as a Strategic Imperative”. Further, the findings highlighted the competencies, support mechanisms, and barriers which select nurses faced while integrating the health promotion strategies in practice.