Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic associations between interpersonal needs and suicidal ideation in a sample of individuals with eating disorders

Abstract Background Over half of individuals with eating disorders experience suicidal ideation at some point in their lives, yet few longitudinal studies have examined predictors of ideation in this at-risk group. Moreover, prospective research has focused on relatively distal or trait-level factors that are informative for distinguishing who is most at risk but not when. Little is known about more proximal or state-level risk factors that fluctuate within an individual, which is critical for determining when a person is most likely to engage in suicidal behaviors. Methods Women (N = 97) receiving treatment for their eating disorder completed questionnaires weekly to assess suicidal ideation and interpersonal constructs (i.e. perceived burdensomeness, thwarted belongingness) theorized to be proximal predictors of suicidal desire. Longitudinal multilevel models were conducted to examine both within- and between-person predictors of suicidal ideation across 12 weeks of treatment. Results Statistically significant within-person effects for burdensomeness (β = 0.06; p < 0.001) indicate that when individuals have greater feelings of burdensomeness compared to their own average, they also experience higher suicidal ideation. We did not find any significant influence of thwarted belongingness or the interaction between burdensomeness and belongingness on suicidal ideation. Conclusions This study was the first to examine dynamic associations between interpersonal constructs and suicidal ideation in individuals with eating disorders. Results are only partially consistent with the Interpersonal Theory of Suicide and suggest that short-term changes in burdensomeness may impact suicidal behavior in individuals with eating disorders.
Frizzled-2 small interfering RNA protects hepatic BRL-3A cells against Hypoxia / Reoxygenation via modulation of autophagy.

BACKGROUND/AIMS Autophagy plays a positive role in the prevention of liver damage after hepatic ischemia-reperfusion injury (HIRI); however, the molecular mechanism is still a mystery. Understanding the molecular events behind this injury may have important implications for devising proper strategies for managing liver injury. This study investigated the effects of Frizzled-2 expression on autophagy as well as Ca2+ concentration and apoptosis in BRL-3A cells. MATERIALS AND METHODS BRL-3A cells exposed to the hypoxia/reoxygenation (H/R) condition were used as an in vitro HIRI hepatic cell model. The transfection of Frizzled-2 small interfering RNA (siRNA) or expression vector was performed to silence or overexpress Frizzled-2 in BRL-3A cells. The intracellular Ca2+ concentration was monitored by the fluorescence of Ca+. Western blot was used to detect autophagy-related proteins and apoptotic marker Caspase-3. The cellular autophagosome was observed by a transmission electron microscope. RESULTS Beclin-1 and Atg7 expressions were considerably induced by H/R treatment, and this induction was attenuated by Frizzled-2 siRNA in BRL-3A cells. The LC3B-II/I ratio was inhibited by H/R treatment, although it was considerably induced by Frizzled-2 siRNA. The overexpression of Frizzled-2 induced intracellular Ca2+ concentration and expressed autophagy-related proteins and Caspase-3 except for the suppression of LC3B-II/I ratio in BRL-3A cells in the normoxia condition. CONCLUSION The overexpression of Frizzled-2 mimicked H/R treatment and suppressed autophagy activity, whereas Frizzled-2 siRNA induced cellular autophagy and attenuated the H/R-induced hepatic injury in BRL-3A cells. These developments suggest that Frizzled-2 siRNA protects hepatic BRL-3A cells from the injury of H/R via autophagy modulation.
POWER ALLOCATION AND ECHO CANCELLATION ANALYSIS FOR COOPERATIVE MIMO-OFDMA CHANNEL

Multiple Inputs and Multiple Output (MIMO) and Orthogonal Frequency Division Multiplexing (OFDM) system have the potential to attain high capability on the propagation setting. The reduction of power consumption in co-operative multiuser OFDMA systems is a great challenge in multipath environment. The power distribution among multi users in relay path has more complexity when compared to that of the shortest path. Subcarrier resource allocation move toward is the main interest in this paper, it is a method that is based upon the nodes that are able to transmit as well as receive on adjacent OFDM subcarriers at the same time. In this particular approach there will be a performance trade off in realistic conditions as adjacent subcarriers will not be totally isolated and readily available on the receiving subcarriers that are adjacent to those that are transmitting and there will be no interference. In this paper we look into the performance of such cooperative OFDMA systems under realistic conditions and relay path of cooperative communication on different modulations like 16QAM, 64QAM, 128QAM AND 256QAM using power consumptions for this propose we proposed a transceiver structure to reduce the interference between transmitting subcarriers as well as at the receiving subcarriers. Its performance can be stated terms of signal to interference and noise ratio (SINR) and is evaluated by both analysis and simulation and it is incorporated into a recently proposed cooperation strategy for OFDMA systems to examine its performance under the realistic structure.
Pathogenicity of the entomopathogenic fungus

Rhipicephalus evertsi evertsi is an economically-important tick of livestock in Africa mainly due to its ability to transmit Babesia equi to horses, Anaplasma marginale to cattle and to cause paralysis in lambs, adult sheep and calves. This study investigated the pathogenicity and hence the bio-control potential of Metarhizium anisopliae to eggs and all other off-host stages of R. e. evertsi. The eggs and larvae were infected by placing them on filter paper wetted with conidial suspension. Tick instars were infected by dipping in M. anisopliae suspenssion (1×10 3 –10 8 conidia/ml) and incubated together with the eggs at 25°C and 100% relative humidity (RH). The m ortality of eggs and all tick stages tested increased with increasing conidial concentration and were higher (P>0.05) in conidia formulated in oil than in those formulated in water. For instance, the LC50 in unfed larvae was 1×10 4 conidia /ml in oil formulation and
Targeting EZH2 by microRNA-449a inhibits osteosarcoma cell proliferation, invasion and migration via regulation of PI3K/AKT signaling pathway and epithelial-mesenchymal transition.

OBJECTIVE Osteosarcoma (OS) is one common bone malignant tumor prevailing in young adults and children. It is increasingly recognized microRNA 449a (miR 449a) as an anti-tumor factor in various tumours. However, little is known about the biological significance of miR 449a in OS. The intent of our study was to seek the prognostic values of miR-449a in OS. PATIENTS AND METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to examine the level of miR-449a expression in 48 pairs of OS tissues and para-cancerous specimens, and the relationship between miR-449a level and clinical features of OS patient prognosis was analyzed. Moreover, we measured the miR-449a expression levels in OS cells. Transwell assay was further performed to investigate whether miR-449a influenced MG63 cell migration and invasion, which was important for malignant metastases. RESULTS Quantitative real-time polymerase chain reaction (qRT-PCR) analysis demonstrated a notable decrease of miR-449a expressions in OS. The declined miR-449a expression was relevant with the poor prognosis and malignant clinicopathologic characteristics of OS patients. Thereafter, the functional assay was performed to determine the role of miR-449a in OS progression. Results of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assays and transwell assays indicated that miR-449a overexpression significantly repressed OS cell proliferation, invasion, and migration. Furthermore, luciferase reporter assay showed that enhancer of zeste homolog 2 (EZH2) was a downstream target of miR-449a in OS cells. Additionally, Western blot analysis demonstrated that miR-449a exerted anti-OS functions via the regulation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway and epithelial-mesenchymal transition. We also indicated that miR-449a restoration could inhibit in vivo tumor growth. CONCLUSIONS These results manifested that miR-449a may thus be used as a therapeutic target in OS treatments.
Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy

Pregnancy constitutes a major challenge to the maternal immune system, which must tolerate fetal alloantigen encoded by paternal genes. In addition to their role in inducing maternal-fetal immune tolerance, accumulating evidence indicates that decidual immune cells are involved in several processes required for a successful pregnancy, including trophoblast invasion as well as tissue and spiral artery remodeling. Innate lymphoid cells (ILCs), an important branch of the innate immune system, which has expanded rapidly in recent years, are strong actors in mucosal immunity, tissue homeostasis and metabolism regulation. With the recent identification of ILCs in the human decidua, the role of ILCs at the maternal-fetal interface raises concern. Herein, we review the presence and characterization of ILCs in the human decidua, as well as their function in normal pregnancy and pathological pregnancy, including reproductive failure, preeclampsia and others.
Rate of Pseudophakic Cystoid Macular Edema Using Intraoperative and Topical NSAIDs Alone without Steroids.

PURPOSE To determine the rate of postoperative cystoid macular edema (CME) in patients undergoing cataract surgery treated with intraoperative intracameral and postoperative topical NSAIDs without steroids. SETTING Academic outpatient surgery center in Bermuda Run, NC DESIGN:: Retrospective cohort study METHODS:: A retrospective chart review was performed. Patients were identified through a medical record search tool using criteria of procedure code CPT 66984, a single surgeon and a date range from 1/1/2016 through 12/31/2017. Medical records were reviewed to determine intraoperative and postoperative medication regimen, visual outcome, and development of postoperative CME. Patients with a history of uveitis, diabetic macular edema, retinal vein occlusions, epiretinal membranes, vitreomacular traction or any prior history of macular edema were excluded. Additionally, any patients with less than 6 weeks of postoperative follow-up were excluded. RESULTS Overall, 824 patient records were reviewed, and the analysis included 504 eyes. Two eyes developed postoperative CME (rate = 0.40%, 95% confidence interval 0.0005 to 0.0143). CONCLUSION The rate of CME in patients treated with intraoperative and postoperative nonsteroidal anti-inflammatory drugs without steroids was low and below historical rates derived from a literature review of CME development with the use of steroids.
A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile

The goals of our study were to determine the possible association of interleukin (IL)-31 with Th17 cytokine profile in serum and to quantify retinoic acid-related orphan receptor C (RORC) mRNA expression in psoriatic arthritis (PsA) patients. This cross-sectional study was conducted in 50 patients with PsA and 30 control subjects (CS) matched by age and gender. The cytokine serum levels were quantified by magnetic bead–based assay using the Bio-Plex MAGPIX system, and RORC mRNA expression was determined by quantitative polymerase chain reaction (qPCR). As a result, significant differences in IL-31 were observed between study groups (77.23 pg/mL in PsA vs 64.4 pg/mL in CS, P < 0.001) and Th17 cytokine profile serum levels (IL-17A: 6.36 pg/mL in PsA vs 2.97 pg/mL in CS, P = 0.02; IL-17F: 44.15 pg/mL in PsA vs 23.36 pg/mL in PsA, P = 0.01; IL-17E: 3.03 pg/mL in PsA vs 0.82 pg/mL in CS, P < 0.001; IL-21: 36.45 pg/mL in PsA vs 12.44 pg/mL in CS, P = 0.02); however, significant differences were not observed for IL-23 (31.2 pg/mL in PsA vs 53.26 pg/mL in CS, P = 0.58). Furthermore, positive correlations between IL-31 and Th17 cytokine profile serum levels were found (IL-17A: rs = 0.64, P < 0.001; IL-17F: rs = 0.73, P < 0.001; IL-17E: rs = 0.70, P < 0.001; IL-21: rs = 0.54, P = 0.002; IL-23: rs = 0.5, P < 0.01). Regarding RORC gene expression, the PsA group showed an increase of 6.85-fold compared to the CS group. We did not find any association between the serum levels of cytokines and RORC gene expression. In conclusion, in PsA, there are increased serum levels of IL-31, IL-17A, IL-17F, IL-17E, and IL-21, but not IL-23. Moreover, there was a positive correlation of IL-31 with the Th17 cytokine profile and a high RORC gene expression. Altogether, these findings suggest a proinflammatory contribution of IL-31 in close association with the Th17 cytokine profile in PsA.
Activation of Retinal Angiogenesis in Hyperglycemic pdx1−/− Zebrafish Mutants

Progression from the initial vascular response upon hyperglycemia to a proliferative stage with neovacularizations is the hallmark of proliferative diabetic retinopathy. Here, we report on the novel diabetic pdx1−/− zebrafish mutant as a model for diabetic retinopathy that lacks the transcription factor pdx1 through CRISPR-Cas9–mediated gene knockout leading to disturbed pancreatic development and hyperglycemia. Larval pdx1−/− mutants prominently show vasodilation of blood vessels through increased vascular thickness in the hyaloid network as direct developmental precursor of the adult retinal vasculature in zebrafish. In adult pdx1−/− mutants, impaired glucose homeostasis induces increased hyperbranching and hypersprouting with new vessel formation in the retina and aggravation of the vascular alterations from the larval to the adult stage. Both vascular aspects respond to antiangiogenic and antihyperglycemic pharmacological interventions in the larval stage and are accompanied by alterations in the nitric oxide metabolism. Thus, the pdx1−/− mutant represents a novel model to study mechanisms of hyperglycemia-induced retinopathy wherein extensive proangiogenic alterations in blood vessel morphology and metabolic alterations underlie the vascular phenotype.
Modified Wilkinson Compact Wide Band (2-12GHz) Equal Power Divider

A novel compact wideband (2-12 GHz) Wilkinson equal power divider on microstrip line is proposed in this paper. In this paper, a novel approach to the design of a Wideband (2-12) power divider is presented. In order to achieve the wideband performance, the divider is established by introducing variable width of microstrip line between input lines to output lines of different impedance. Finally, a compact power divider is designed, and it is demonstrated that 3 dB powers splitting from one input port to two output ports is achieved. In addition, good impedance matching at all the three ports and excellent isolation between two output ports are obtained over the specified 2-12 GHz WB range. The simulated and measured input return loss is approximately 21 dB at center frequency 7.92 GHz. The average insertion loss, and group delay are around 3 dB (including the 3-dB power-dividing insertion loss) and around 0.09 ns over across the WB. In addition, the measured and simulated isolation between the output ports is approximately 25 dB at center frequency 7.92 GHz.
Association Between Patterns of Alcohol Use and Short-Term Risk of Suicide Attempt Among Patients With and Without Reported Suicidal Ideation

Supplemental Digital Content is available in the text Objective: To evaluate the association between patterns of alcohol use and short-term risk of suicide attempt among patients with and without reported suicidal ideation. Methods: Kaiser Permanente Washington electronic health record data were used to identify mental health visits (1/1/2010-6/30/2015) with documented assessments for unhealthy alcohol use (AUDIT-C) and suicidal ideation (PHQ-9 ninth question). Logistic regression fit using generalized estimating equations were used to conduct visit-level analyses, accounting for correlation between individuals’ assessments. Separate models evaluated the association between (1) level of alcohol consumption and (2) frequency of heavy episodic drinking (HED), in combination with suicidal ideation (any vs none), with suicide attempt within 90 days following each visit. Primary models adjusted for age, gender, race/ethnicity and visit year. Results: Of 59,705 visits (43,706 unique patients), 372 (0.62%) were followed by a suicide attempt within 90 days. The risk of suicide attempt was significantly higher for patients reporting suicidal ideation across all levels of alcohol consumption compared to patients reporting low-level alcohol use and no suicidal ideation, particularly high-level use (OR 9.77, 95% CI, 6.23–15.34). Similarly, risk of suicide attempt was higher for patients reporting suicidal ideation across all levels of HED relative to those reporting no HED or suicidal ideation, particularly HED monthly or more (OR 6.80, 95% CI 4.77–9.72). Among patients reporting no suicidal ideation, no associations were observed. Conclusions: Findings underscore the potential value of offering alcohol-related care to patient reporting suicidal ideation. Additional strategies are needed to identify suicide risk among those reporting no suicidal ideation.
滤泡性淋巴瘤相关基因突变的研究进展

Progress in the research of gene mutations in follicular lymphoma Zhou Yu, Shi Yuankai Department of Medical Oncology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing 100021 Corresponding author: Shi Yuankai, Email: syuankai@cicams.ac. cn
Distributed Routing for Interference Minimization in Cognitive Radio Networks

: We investigate the problem of total interference minimization at primary user under the constraint of end-to-end data rate in cognitive radio networks. To solve the problem a cross layer approach is adopted. Closed form expression for power allocation is obtained and from which routing metric and spectrum assignment policy is also extracted. Distributed implementation related to the proposed optimal routing, power allocation and channel allocation scheme is also proposed. Simulation results show that o ur proposed optimal approach succeeds in reducing interference to primary user in a significant manner.
Effective forewarning requires central route processing: Theoretical improvements on the counterargumentation hypothesis and practical implications for scam prevention

Financial scams have caused tremendous financial damage globally. In Japan, the police forewarn people by equipping them with scam-prevention techniques or providing awareness regarding examples of previous scams; however, this does not appear to effectively prevent the damage, as many scam victims do not remember these warnings when faced with actual scam encounters. Considering that scammers often use appeal to emotion techniques, peripheral processing during scam attempts might disturb people’s abilities to recall the warnings on scammers’ modus operandi, thus leading to failed counter-arguing efforts. We verified this hypothesis in an experimental setting by asking 162 participants to remember given forewarnings and resist deceptive advertisements. The results showed that participants gave the advertisers’ manipulative intent a higher rating only when they processed the advertisement through a central route, in addition to being forewarned. This means that forewarning had no effect when participants processed the advertisement through a peripheral route. Moreover, forewarning recollection levels mediated the effect of processing route on this rating, which suggests that remembering forewarnings is necessary to generate counterarguments. This result expands the theory on forewarning effects and explains why people are susceptible to scam victimization. Furthermore, it provides implications for scam prevention.
Coronary Artery Disease Risk Factors among Females in a Tertiary Cardiac Centre in Nepal: A Case Control Study

Background: Although in recent decades risk factors of Coronary Artery Disease (CAD) have markedly increased, little is known about its relationship among Asian females. The principal aim of the study is to determine the prevalence of CAD risk factors among a target female population in Nepal. Methods: A case control study was conducted at tertiary cardiac centre of Kathmandu from August 2013 to September 2014. Study participants identified with CAD (n=52) were matched for age with controls (n=52). Anthropometric and laboratory data were collected and a semi-structured interview was utilized to obtain information on socio-demographic, behavioural, psychosocial and physiological/ biochemical risk factors. Variables were assessed using frequency tables and Pearson’s Chi-Square tests for two independent proportions. Binary logistic regression was used to investigate the potential predictors of CAD. Results: CAD was significantly associated with ethnicity, ever smoked, harmful use of alcohol, moderate physical activity, more than 12 sitting hours per day, family history, total cholesterol, HDL-C and hypertension. Regression analysis indicated alcohol intake (P<0.01), LDL-C, diabetes (P<0.01), BMI ≥ 27.5 kg/m2 (P<0.01) as significant predictors of CAD. Conclusion: Diabetes, drinking alcohol, LDL-C and generalized obesity were found to be significant predictors of CAD. Aside from family history, all associated risk factors within our study population are modifiable risk factors. CAD has been identified as public health priority in Nepal given the current and predicted burden of all forms of heart disease within the country. Further research in women in developing countries will be key, given the rising levels of risk factors and morbidity rates within the region.
Distribution of Arsenic and Heavy Metals from Mine Tailings dams at Obuasi Municipality of Ghana

This present study investigated the issue of gold mine tailings dams as a potential source of arsenic and other trace elements contamination and their dissolution into the adjoining environmental media in Obuasi Municipality of Ghana. One active (Sanso tailings dam) and two abandoned (Pompora and Dokyiwa) mine tailings dams in Obuasi gold mine site, were selected for the collection and analysis of the tailings. The concentrations of As, Fe, Mn, Cu and Zn were determined using an atomic absorption spectrometer (AAS, Varian Models 240FS). The total concentrations of elements in the mine tailings were up to 1752 mg/kg As, 75.16 wt. % Fe, 1848.12 mg/kg Mn, 92.17 mg/kg Cu and 7850 177.56 mg/kg Zn. Sulfate was the dominant anion throughout the leachate, reaching a maximum dissolved concentration of 58.43 mg/L. The mine tailings were contaminated with much higher concentrations of As and heavy metals than the Netherlands soil protection guideline values. Leaching levels of As were in the range of 0.04–0.56 %, presenting high proportions for the total arsenic content in the mine tailings.