Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of Cold‐Inducible RNA‐Binding Protein in the Normal Endometrium, Endometrial Hyperplasia, and Endometrial Carcinoma

&NA; Cold‐inducible RNA‐binding protein (CIRP), an 18‐kD protein in the mouse and human, is induced by lowering the temperature of cultured cells. CIRP is possibly a cell cycle regulator because its overexpression results in prolongation of G1 phase in vitro. We investigated the immunohistochemical expression of CIRP in 39 endometrial carcinomas, 12 endometrial hyperplasias, and 27 normal endometria using polyclonal antibody against CIRP and confirmed by Western blot analysis. CIRP was localized in the nuclei of glandular, stromal, and endothelial cells. The intensity of CIRP expression in glandular cells during the menstrual cycle was inversely proportional to its proliferative (Ki‐67) activity, whereas it remained unchanged in stromal and vascular endothelial cells. The intensity of CIRP expression in hyperplastic glands was variable, whereas CIRP expression was absent or markedly reduced in most of the endometrial carcinomas. These results suggest that CIRP may participate in the cell cycle regulation of normal endometrium and the loss of its expression may be involved in endometrial carcinogenesis.
110GHz power splitting/combining network based on waveguide rat-race hybrid

In this paper, a 110 GHz power splitting/combining network based on waveguide rat-race hybrid is proposed, which has the merits of low insertion loss and excellent consistency in amplitude and phase. The simulation results show that at the frequency 100-110 GHz, the return loss is superior to 20 dB, and the insertion loss is less than 0.5 dB. The measurement results of the fabricated power splitting/ combining network show that at the frequency 105-110 GHz, the return loss is superior to 16 dB, and the insertion loss is less than 3.4 dB.
The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation

Targeting immune cells that support tumor growth is an effective therapeutic strategy in tumor entities such as melanoma. M2-like tumor-associated macrophages (TAM) sustain tumor growth by secreting anti-inflammatory cytokines, proteases and growth factors. In this study, we show that a protein derived from M2-like macrophages namely the shedded ectodomain of Lyve-1 (sLyve-1) decreases human HT144 and murine B16F1 melanoma cell proliferation significantly by acting as a decoy receptor for low-molecular weight hyaluronic acid (LMW-HA) although the LMW-HA/Lyve-1 interaction on lymphatic endothelial cells has been described to induce lymphangiogenesis. This is in line with our finding that the number of LYVE-1+ TAM decreases in higher human melanoma stages and that the early growth of B16 transplant tumors is enhanced in Lyve-1 knockout mice when compared to wild-type mice due to an increased melanoma cell proliferation. LYVE-1 expressing TAM are however true M2 macrophages as they co-express typical M2-markers such as CD163 and CD206. The results of the present study highlight the necessity to carefully determine the net effect particular TAM subpopulations have on tumors before establishing a treatment to target these immune cells.
Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia

In early pregnancy, trophoblasts and the fetus experience hypoxic and low-nutrient conditions; nevertheless, trophoblasts invade the uterine myometrium up to one third of its depth and migrate along the lumina of spiral arterioles, replacing the maternal endothelial lining. Here, we showed that autophagy, an intracellular bulk degradation system, occurred in extravillous trophoblast (EVT) cells under hypoxia in vitro and in vivo. An enhancement of autophagy was observed in EVTs in early placental tissues, which suffer from physiological hypoxia. The invasion and vascular remodeling under hypoxia were significantly reduced in autophagy-deficient EVT cells compared with wild-type EVT cells. Interestingly, soluble endoglin (sENG), which increased in sera in preeclamptic cases, suppressed EVT invasion by inhibiting autophagy. The sENG-inhibited EVT invasion was recovered by TGFB1 treatment in a dose-dependent manner. A high dose of sENG inhibited the vascular construction by EVT cells and human umbilical vein endothelial cells (HUVECs), meanwhile a low dose of sENG inhibited the replacement of HUVECs by EVT cells. A protein selectively degraded by autophagy, SQSTM1, accumulated in EVT cells in preeclamptic placental biopsy samples showing impaired autophagy. This is the first report showing that impaired autophagy in EVT contributes to the pathophysiology of preeclampsia.
Chemical composition, allelopatic and cytotoxic effects of essential oils of flowering tops and leaves of Crambe orientalis L. from Iran

Crambe orientalis L. (Brassicaceae), a perennial herb, is indigenous to Iran. The essential oils of flowering tops and leaves of the plant were evaluated by GC-MS. Our results showed that while 2-methyl-5-hexenitrile (19.5%) and benzyl cyanide (16.9%) were the major components of flowering tops oil, the oil of the leaves was dominated by octyl-acetate (54.3%) and butenyl-4-isothiocyanates (22.6%). The oils exhibited modest allelopatic effects on lettuce. The leaf oil showed high-cytotoxic effects against Mc-Coy cell lines, with an RC50 value of 16 µg mL−1.
IoT application development: Home security system

One of the prominent application segment of Internet of Things framework is in the Security Sector. It is important to arrive at a unique low cost solution to prevent theft and ensure security to members of the home. The Internet of Things(IoT) Layered Architecture based design approach assists the system designer to conveniently differentiate the system component requirements distinctly at various layers. This papers highlights the model driven development process for Home Security System. It remarks the uses of customers end application such as Telegram to securely transmit information through layers of IoT architecture. This paper aims at providing a low-power, cost effective and unobtrusive IoT based home security system which assist in presence detection, identification and authentication of stranger. The proposed solution makes use of USB Webcam as an image capturing unit, Electric Door Strike as an actuator and Telegram which has an amazing feature as Telegram Bot which provide APIs to build solutions which is compatible with Raspberry Pi IoT infrastructure.
Long‐term therapy of chronic hepatitis B with lamivudine

Lamivudine therapy induces improvements in chronic hepatitis B in a high proportion of patients, but prolonged therapy is limited by the development of viral resistance. We analyzed clinical responses and virologic resistance in 27 patients treated continuously with lamivudine for 2 to 4 years. Serum transaminases, hepatitis B virus (HBV) DNA by both branched DNA (bDNA) signal amplification and quantitative polymerase chain reaction were monitored at 4‐ to 8‐week intervals. Virologic resistance to lamivudine was confirmed by the presence of mutations in the YMDD motif of the polymerase gene by restriction fragment‐length polymorphism analysis. Serum HBV‐DNA levels decreased rapidly in all treated patients, falling by 4 to 5 logs within 1 year. Transaminase levels also decreased and were normal in 70% of patients at 1 year, at which point liver histology had improved in 81% of patients. Viral resistance began to emerge after 8 months of therapy, eventually developing in 14 patients, including 76% of hepatitis B e antigen (HBeAg)‐positive patients but only 10% of HBeAg‐negative patients. Lamivudine withdrawal led to reappearance of wild‐type HBV species, but retreatment led to more rapid reappearance of the mutant virus. Clinical, serum biochemical, and histologic improvements were maintained in the 13 patients who did not develop resistance. Thus, long‐term therapy with lamivudine resulted in maintained improvements in virologic, biochemical, and histologic features of disease in most patients with HBeAg‐negative chronic hepatitis B and in the subgroup of HBeAg‐positive patients with high serum transaminase levels. A high rate of resistance limited efficacy, particularly in patients who remained HBeAg positive on therapy.
Economic Compensation of Cultivated Land Protection Based on CVM

The underlying reasons of the loss of cultivated land resources in China lie in inadequate understanding of the total value of cultivated land resources,and China fails to establish the reasonable interest adjustment mechanism.All of these realities resulting in the different comparative benefits between cultivated land and non-agricultural land.Therefore,giving economic compensation to cultivated land protectors is a necessary choice to promote cultivated land protection.The determination of compensation standard is the core of economic compensation of cultivated land protection,and the value of cultivated land resources is the basis of determining compensation standard.Through a comprehensive analysis of the composition of the value of cultivated land resources,this paper considers that the total value of cultivated land resources should include market value and non-market value.Through the revelation of the meaning and the essence of the economic compensation of cultivated land protection,we indicate that the scope of economic compensation should only include the non-market value with positive externalities,which is the ecological value and the social value of cultivated land resources.The non-market value which is calculated by scientific and reasonable method can be the basis for determining compensation standard,contingent valuation method(CVM) can be regarded as a calculation model for determining compensation standard.This paper takes Ruzhou City Henan Province for example,and uses CVM to calculate the economic compensation standard.
The proper folding of a long C‐terminal segment of the yeast Lys14p regulator is required for activation of LYS genes in response to the metabolic effector

Transcription of lysine genes in Saccharomyces cerevisiae is dependent on Lys14p and on α‐aminoadipate semialdehyde (αAASA), an intermediate of the pathway. The two‐thirds C‐terminal end of Lys14p is sufficient to ensure the activation function of the protein and its modulation by αAASA. Here, we show that no single discrete domain of Lys14p is able to activate transcription and that most of the deleted LexA–Lys14p proteins are inactive even in the presence of a high αAASA concentration. The point mutations abolishing the activation capacity of Lys14p are distributed all over the entire C‐terminal segment. Although the deletion of 20 residues rich in leucine and located downstream of the DNA‐binding domain converts Lys14p to a constitutive transcriptional activator, our analysis provides evidence that the modulation process of Lys14p activity does not involve an effector‐dependent masking/unmasking mechanism. Furthermore, we show that the protein chaperone Hsp82p is required for full activation of LYS genes by the αAASA‐activated Lys14p as well as by the constitutive Lys14p. Our results suggest that the proper folding of the two‐thirds C‐terminal portion of Lys14p is essential not only to activate transcription but also to modulate it according to αAASA concentration.
Individual-adapted facial shape transformation based on subspace learning

As the use of high-resolution digital images continues to increase, there is a growing interest in facial image warping or facial image transformation, which is the process of making visual changes to facial images. Several facial image transformation techniques have been proposed and used in many applications. However, most of these techniques warp or transform a facial image to a pre-defined target image. As a result, the transformed image may not maintain the individual features, and sometimes an unnatural facial image is produced. In this paper, we propose a novel subspace learning based method for automatic individual-adapted facial shape transformations. In our proposed method, we first prepared a database containing several tens of pairs of facial images and their manually generated target images, and then constructed a facial shape subspace. We then projected both original facial shapes and their target image shapes onto the subspace and used the B-spline method to estimate the mapping functions from the original shapes to their target shapes. By using the mapping function, the target image shape points of a test facial image could be automatically generated, thus maintaining the original individual features.
Digital mammographic tumor classification using transfer learning from deep convolutional neural networks

Abstract. Convolutional neural networks (CNNs) show potential for computer-aided diagnosis (CADx) by learning features directly from the image data instead of using analytically extracted features. However, CNNs are difficult to train from scratch for medical images due to small sample sizes and variations in tumor presentations. Instead, transfer learning can be used to extract tumor information from medical images via CNNs originally pretrained for nonmedical tasks, alleviating the need for large datasets. Our database includes 219 breast lesions (607 full-field digital mammographic images). We compared support vector machine classifiers based on the CNN-extracted image features and our prior computer-extracted tumor features in the task of distinguishing between benign and malignant breast lesions. Five-fold cross validation (by lesion) was conducted with the area under the receiver operating characteristic (ROC) curve as the performance metric. Results show that classifiers based on CNN-extracted features (with transfer learning) perform comparably to those using analytically extracted features [area under the ROC curve (AUC)=0.81]. Further, the performance of ensemble classifiers based on both types was significantly better than that of either classifier type alone (AUC=0.86 versus 0.81, p=0.022). We conclude that transfer learning can improve current CADx methods while also providing standalone classifiers without large datasets, facilitating machine-learning methods in radiomics and precision medicine.
Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep ApneaSyndrome

Aim: The aim of this study was to assess the insulin resistance and serum leptin levels in patients with obstructive sleep apnea syndrome (OSAS), and to compare body mass indexes (BMI) of OSAS patients with matched controls without OSAS. Method: Twenty eight patients having apnea-hypopnea index (AHI)≥5 included in the study. Thirty two healthy subjects assumed as a control group. Venous blood was obtained in the fasting state for the measurement of glucose, insulin and leptin levels. Insulin resistance index was based on the homeostasis model assesment method (HOMAIR).
Exploring sustainability science: Knowledge, institutions and innovation

Global sustainability concerns long-term constraints on resources, including, among others, food, water and energy. The challenge of sustainability is the reconciliation of society’s development goals with the planet’s environmental limits over the long term (Clark and Dickson, 2003). The new field of sustainability science now being developed aims at understanding the fundamental character of interactions among natural, human and social systems (Clark and Dickson, 2003; Kates et al., 2001; Komiyama and Takeuchi, 2006). Sustainability science concerns various domains, including nature (for example, climate, oceans, rivers, plants and other components of the natural environment), technology (for example, machinery, chemicals, biotechnology, materials and energy) and society (for example, economy, industry, finance, demography, culture, ethics and history). The academic landscape of sustainability science likewise consists of clusters of diverse disciplines (Kajikawa et al., 2007).
Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression.

Phosphatidylserine (PS) exposure on the surface of cells has been considered a characteristic feature of apoptosis. However, we demonstrate herein that externalization of PS occurs in a cell-type-specific, albeit caspase-dependent, manner. Moreover, we could find no correlation in six different cell lines between the level of expression of the phospholipid (PL) scramblase and the capacity of these cells to externalize PS during apoptosis. Overexpression of PL scramblase in Raji cells, which exhibit low constitutive expression of this enzyme, by retroviral transduction of PL scramblase or treatment of the cells with interferon-alpha, failed to confer the capacity to expose PS in response to apoptotic stimuli. However, the lack of PS exposure in some cell types was not due to their inability to translocate PS molecules to the cell surface, since incubation with thiol reactive agents, such as N-ethylmaleimide, disulfiram and diamide, yielded rapid and pronounced PS exposure in all cell lines. These data suggest that plasma membrane PS exposure is not an obligatory component of the apoptotic phenotype, and that PL scramblase is not the sole determinant of PS externalization in apoptotic cells when this occurs.
Relationship between fertility duration and in vivo sperm storage in broiler breeder hens.

1. Seventy Hubbard hens, 75 weeks of age, were divided into groups containing equal numbers of hens on the basis of duration of fertility. Average fertile periods were 14.5 d (long, L) and 6.9 d (short, S). Each hen was artificially inseminated (AI) on three consecutive days with an average of 1.61 X 10(9)/0.05 ml spermatozoa per insemination. Seven hens from each group were killed 1, 3, 6, 9, and 13 d after insemination. 2. Three longitudinal sections of uterovaginal junction were evaluated microscopically for spermatozoal storage capacity by assigning each sperm host gland (SHG) to one of 5 categories: unscorable, empty, one to 5 spermatozoa, 6 to 20 spermatozoa and greater than 20 spermatozoa. 3. The only significant difference in sperm storage at any time between the L and S duration groups occurred at day 1 after AI, when L duration hens possessed significantly more glands with more than 20 spermatozoa. 4. One day after AI the proportion of SHG containing sperm were 28.8% (L group) and 18.6% (S group). There was a significant decrease in the number of glands containing 1 to 5, 6 to 20 and greater than 20 spermatozoa between days 1 to 3 in both groups. 5. Numbers of glands in all categories containing sperm decreased throughout the 13-d period. The L duration group possessed 18.5% more glands with 1 to 5, 6 to 20 and greater than 20 spermatozoa than the S duration group. 6. There were no significant differences between groups in the proportion of unscorable or empty glands throughout, which ranged from 35.9 to 56.8% and 36.3 to 47.1%, respectively. (ABSTRACT TRUNCATED AT 250 WORDS)
A Novel Method for onLine Monitoring Engine Oil Quality Based on Tapered Optical Fiber Sensor

This paper introduces a highly sensitive, rapid, and low-cost sensing method for online analysis of engine oil quality and predicts the exact time of oil expiration. The multi-mode optical fiber is tapered with great accuracy in measuring the fresh and expired oil refractive indices in mechanical systems. In this paper, the length and diameter of the tapered area of the fiber are optimized by the chemical etching method in different time periods using 20% (V/V) hydrofluoric acid. The oil acts as the external medium for this sensor, and any changes in quality, particle size, and pollution of the oil will consequently affect optical properties, such as the variation in the optical power output. By comparing the optical powers between fresh and used oil, the exact quality of the oil is predicted.
Functional analysis of the chromo domain of HP1.

Heterochromatin protein 1 (HP1) is a non‐histone chromosomal protein in Drosophila with dosage‐dependent effects on heterochromatin‐mediated gene silencing. An evolutionarily conserved amino acid sequence in the N‐terminal half of HP1 (the ‘chromo domain’) shares > 60% sequence identity with a motif found in the Polycomb protein, a silencer of homeotic genes. We report here that point mutations in the HP1 chromo domain abolish the ability of HP1 to promote gene silencing. We show that the HP1 chromo domain, like the Polycomb chromo domain, has chromosome binding activity, but to distinct chromosomal sites. We constructed a chimeric HP1‐Polycomb protein, consisting of the chromo domain of Polycomb in the context of HP1, and show that it binds to both heterochromatin and Polycomb binding sites in polytene chromosomes. In flies expressing chimeric HP1‐Polycomb protein, endogenous HP1 is mislocalized to Polycomb binding sites, and endogenous polycomb is misdirected to the heterochromatic chromocenter, suggesting that both proteins are recruited to their distinct chromosomal binding sites through protein‐protein contacts. Chimeric HP1‐Polycomb protein expression in transgenic flies promotes heterochromatin‐mediated gene silencing, supporting the view that the chromo domain homology reflects a common mechanistic basis for homeotic and heterochromatic silencing.
In press: Journal of Experimental Psychology: Human Perception and Performance Optimal task-sets override attentional capture by rare cues

Many studies converge on the conclusion that spatially irrelevant precues do not capture attention when cue and target features do not match. However, a recent study reported that rare onset cues captured attention even though observers searched for a non-matching color target. Hence, attentional capture by rare onsets cues might be cognitively impenetrable (Folk & Remington, 2015). Although we replicated these findings (Experiment 1), we hypothesized that capture by rare onset cues can be prevented when the target display promotes a stronger task-set for the target or suppression of the cue features (i.e., a white onset). Therefore, we presented the color target together with a single white nontarget, and indeed found that the rare onset cues failed to capture (Experiment 2). Moreover, we examined the previous suggestion that frequency effects are limited to onset cues by presenting rare color cues with non-matching color targets (Experiment 3). We observed capture by rare color cues, but again, capture could be prevented when a nontarget in the cue color was added to the target display (Experiment 4). Overall, these findings suggest that capture by rare cues can be prevented when the suppressive bias against nontarget features is optimally directed against the cue properties.
In good times and bad: p73 in cancer

It is widely accepted in cancer biology that p53 has a tumor suppressive activity, which is lost during tumorigenesis most frequently by mutations in the p53 gene. The discovery of p73 as the first homologue of p53 raised immediate expectations about p53-like tumor suppressor activities. Although tumors show changes in the expression level of p73 and differences in the expression pattern of p73 isoforms, mutations are not commonly observed making it difficult to infer p73's role in tumorigenesis. An experimental model of human cell transformation closely mimics the expression changes observed in cancer patients and provides novel insights into the regulation and function of p73 in the various steps on the road to malignant transformation. p53-like isoforms of p73 (TAp73) are upregulated early during the transformation process in response to RB pathway alterations and block progression to the fully transformed state. Antagonists of TAp73 such as the dominant-negative p73 protein ΔNp73 overcome this block and pave the way to full transformation. Here we review these findings in the context of patient data and recent advances on molecular aspects of p73 function and discuss the implications for p73 as a target for cancer therapy.