Miracle-dz/UniFAR-FTUs huggingface dataset:
How Do Educational Researchers Utilize from Social Media?

Gunumuzde kullanim oranlari gittikce artan sosyal medyadan bireyler farkli yollarla faydalanmaktadirlar. Bu kesif arastirmasinda, egitim arastirmacilarinin sosyal medya kullanimlari ve sosyal medyayi egitim amacli bir arastirma, ogretim ve ogrenim ortami olarak kullanmalari hakkindaki gorusleri arastirilmistir. Bu calismaya egitim alaninda calisma yapan toplam 207 arastirmaci katilmistir. Sonuclar, arastirmacilarin %62'sinin, onceki egitim calismalari icin sosyal medyadan yararlandigini ve bunlarin %90'inin, yakin gelecekte de egitim calismalari icin sosyal medyadan yararlanmayi planladiklarini gostermektedir. Egitim arastirmacilarinin cogu, egitim calismalarinda sosyal medyanin kullanimi hakkinda olumlu dusunceye sahiptirler. Ancak egitim calismalarinda sosyal medya kullanimiyla ilgili literaturun yetersizliginden sikayetcidirler. Calismaya katilan arastirmacilardan Bilgisayar ve Ogretim Teknolojileri Egitimi Bolumu'nde calisan akademik personelin sosyal medyadan daha etkili yararlandiklari gorulmustur. Genc arastirmacilarin sosyal medyayi daha cok kullanma egiliminde olduklari bulunmustur. Ayni zamanda sosyal medyayi gunluk yasamlarinda daha etkin kullanan arastirmacilar egitim calismalarinda da sosyal medyadan daha yogun yararlanmaktadirlar. Egitim arastirmacilarinin teknik bilgi eksikliklerinin giderilerek sosyal medya ogelerini benimsemeleri ve kullanmalari tesvik edilebilir.
“Fake” Tariff News: Is Corporate America Concerned with Trade Wars?

The effect a trade war would have on corporate America is a widely disputed hot topic. On one hand, the trade dispute may discourage abusive trade practices by foreign companies; on the other, it may hurt American exporters, raise costs for manufacturers, and interrupt companies’ supply chains. The authors shed some light on this question by examining the language of earnings call transcripts in the April–August 2018 period, the earliest voluntary disclosure by US companies to communicate their views on this topic to investors. They find that the tone of the conference calls in which companies mention trade tariffs is more negative than a matched control sample. They also find that investors do not share in the pessimism expressed by call participants, and actually reward tariff talk with higher but more volatile stock returns. TOPICS: Fundamental equity analysis, legal/regulatory/public policy, performance measurement
Synaptic Plasticity and Pain: Role of Ionotropic Glutamate Receptors

Pain hypersensitivity that develops after tissue or nerve injury is dependent both on peripheral processes in the affected tissue and on enhanced neuronal responses in the central nervous system, including the dorsal horn of the spinal cord. It has become increasingly clear that strengthening of glutamatergic sensory synapses, such as those established in the dorsal horn by nociceptive thin-caliber primary afferent fibers, is a major contributor to sensitization of neuronal responses that leads to pain hypersensitivity. Here, the authors review recent findings on the roles of ionotropic glutamate receptors in synaptic plasticity in the dorsal horn in relation to acute and persistent pain.
Endoplasmic reticulum: a dynamic patchwork of specialized subregions.

Already in 1955, the endoplasmic reticulum (ER)1 was recognized to include a smooth and a rough portion, distinguished by the attached ribosomes (SER and RER, respectively). Soon thereafter, ribosomes were detected also on the outer membrane of the nuclear envelope (NE), which since then has been included in the ER (see Palade, 1975, and references therein). Membrane continuities between the SER and the RER, as well as between the RER and the NE, have been demonstrated in a variety of cells. As a consequence, the ER membrane is widely viewed as a continuous sheet enclosing a single lumen. This continuity warrants the ER the status of an organelle, i.e., a discrete intracellular structure surrounded by membrane boundaries. In functional terms, this concept coincides with that of a "compartment. " However, problems in defining the ER as a compartment stem from the coexistence in this organelle of multiple, sometimes apparently antithetic, functions. Moreover, in recent models of intracellular membrane traffic, static distinctions such as that between ER and the Golgi complex (GC) are being reinterpreted as the result of complex dynamic equilibria (Pelham, 1991; Klausner et al., 1992; Mellman and Simons, 1992). By now, new criteria are therefore needed to establish which structure belongs to which compartment. A large body of evidence has documented the key role that the C-terminal motif KDEL, recognized by a specific recycling receptor, plays in maintaining resident proteins within the ER lumen (Munro and Pelham, 1987; Lewis and Pelham, 1992). Among the KDEL-bearing proteins, at least two work coordinately to assist protein folding within the ER: BiP, an ATPase capable of interacting with misfolded or unassembled proteins, and protein disulfide isomerase (PDI) (see Gething and Sambrook, 1992 and references therein). In view of their function in chaperoning nascent proteins, BiP and PDI were originally thought to be restricted to the RER. However, recent results demonstrate the apparently uniform dis-
Real time electrocardiogram wave peak detection algorithm and its implementation on FPGA

A real time Electrocardiogram wave peak detection algorithm with low latency has been developed. It can detect different component wave peaks, viz., P, Q, R, S and T from digitized samples. The algorithm has been implemented using Xilinx Spartan-III xc3s400tq144-5 FPGA module. For the purpose of detection of ECG wave peaks, during a training period of 6 second, a slope and polarity based signature is learned from the incoming ECG signal, which is sampled at 1 kHz frequency. These detected signatures of individual wave peaks of the concerned are then used for detection of subsequent individual component wave peaks. R, T and P waves are detected with 98.8%, 97.98% and 97.75% respectively using ptbdb and mitdb data from Physionet. The design consumed 35% resources of FPGA.
Meta-analysis of Viscocanalostomy Versus Trabeculectomy in Uncontrolled Glaucoma

PurposeCompare the efficacy and safety profile of viscocanalostomy versus trabeculectomy in uncontrolled glaucoma. Patients and MethodsWe looked through various search engines for randomized controlled trials directly comparing viscocanalostomy with trabeculectomy. Outcome measurements we examined were mean intraocular pressure difference at 6 months, 12 months, and 24 months, mean difference in postoperative number of antiglaucomatous medications and relative risk of adverse events. Subgroup analysis looked at studies that included 1 eye per patient, studies that included only white patients, studies with only primary open angle glaucoma, studies that did not allow the use of intraoperative mitomycin C in trabeculectomy treatment, studies that did not allow any postoperative use of antimetabolites, and studies with and without the use of postviscocanalostomy Nd:YAG goniopuncture. ResultsTen randomized controlled trials were selected and included in the meta-analysis with a total of 458 eyes of 397 patients with medically uncontrolled glaucoma. At 6 months, mean intraocular pressure difference was 2.25 mm Hg (95% confidence interval 1.38-3.12), at 12 months it was 3.64 mm Hg (2.74, 4.54), whereas at 24 months it was 3.42 mm Hg (1.80, 5.03). Trabeculectomy was found to have a significantly better pressure-lowering outcome (P<0.0001). Relative risk of adverse events such as perforation of Descemet membrane, hypotony, hyphema, shallow anterior chamber, and cataract formation, were found to be 7.72 (2.37, 25.12), 0.29 (0.15, 0.58), 0.50 (0.30, 0.84), 0.19 (0.08, 0.45), and 0.31 (0.15, 0.64), respectively. Viscocanalostomy had a significantly higher relative risk of intraoperative perforation of Descemet membrane, whereas trabeculectomy had significantly more postoperative adverse events (P⩽0.008). ConclusionsTrabeculectomy was found to have a greater pressure-lowering effect compared with viscocanalostomy. However, viscocanalostomy had a significantly better risk profile.
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures

Green fluorescent protein has revolutionized cell labeling and molecular tagging, yet the driving force and mechanism for its spontaneous fluorophore synthesis are not established. Here we discover mutations that substantially slow the rate but not the yield of this posttranslational modification, determine structures of the trapped precyclization intermediate and oxidized postcyclization states, and identify unanticipated features critical to chromophore maturation. The protein architecture contains a dramatic ≈80° bend in the central helix, which focuses distortions at G67 to promote ring formation from amino acids S65, Y66, and G67. Significantly, these distortions eliminate potential helical hydrogen bonds that would otherwise have to be broken at an energetic cost during peptide cyclization and force the G67 nitrogen and S65 carbonyl oxygen atoms within van der Waals contact in preparation for covalent bond formation. Further, we determine that under aerobic, but not anaerobic, conditions the Gly-Gly-Gly chromophore sequence cyclizes and incorporates an oxygen atom. These results lead directly to a conjugation-trapping mechanism, in which a thermodynamically unfavorable cyclization reaction is coupled to an electronic conjugation trapping step, to drive chromophore maturation. Moreover, we propose primarily electrostatic roles for the R96 and E222 side chains in chromophore formation and suggest that the T62 carbonyl oxygen is the base that initiates the dehydration reaction. Our molecular mechanism provides the basis for understanding and eventually controlling chromophore creation.
Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Objective: To investigate the associations between head and neck cancer (HNC) risk and occupations. Methods: We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC × (OR − 1)/OR.1 Results: Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR = 1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR = 1.38; 95% CI 1.13 to 1.69), painters (OR = 1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC. Conclusions: We found associations between certain occupations and HNC risks, including for subsites, with a duration–response relationship.
Structural modeling and characterization of a thermostable lipase from Bacillus stearothermophilus P1.

The moderate thermophilic bacterium Bacillus stearothermophilus P1 expresses a thermostable lipase that was active and stable at the high temperature. Based on secondary structure predictions and secondary structure-driven multiple sequence alignment with the homologous lipases of known three-dimensional (3-D) structure, we constructed the 3-D structure model of this enzyme and the model reveals the topological organization of the fold, corroborating our predictions. We hypothesized for this enzyme the alpha/beta-hydrolase fold typical of several lipases and identified Ser-113, Asp-317, and His-358 as the putative members of the catalytic triad that are located close to each other at hydrogen bond distances. In addition, the strongly inhibited enzyme by 10 mM PMSF and 1-hexadecanesulfonyl chloride was indicated that it contains a serine residue which plays a key role in the catalytic mechanism. It was also confirmed by site-directed mutagenesis that mutated Ser-113, Asp-317, and His-358 to Ala and the activity of the mutant enzyme was drastically reduced.
Molecular approach to aquatic environmental bioreporting: differential response to environmental inducers of cytochrome P450 monooxygenase genes in the detritivorous subalpine planktonic Crustacea, Daphnia pulex

In order to examine the usefulness of detoxifying genes as molecular markers in different chemical environments, isolation of cytochrome P450 genes (CYPs) belonging to the CYP4 family was performed in different samples from two subalpine populations of Daphnia pulex. The use of degenerate primers allowed us to isolate seven cDNAs. Four of them were assigned to the CYP4C subfamily, and were closely related to previously isolated crustacean CYP4s while the others were assigned to new CYP4AN and CYP4AP subfamilies. Expression studies, using semiquantitative polymerase chain reaction (PCR) followed by Southern blot hybridization with specific probes revealed differences in CYP4C32 and CYP4AP1 expressions between the two populations, which differ in the polyphenol richness of the vegetation surrounding their aquatic habitat. Further exposure to toxic dietary polyphenols showed different CYP induction patterns. Taken together, these preliminary results suggest a possible involvement of CYP4s in the ecological differentiation of subalpine D. pulex populations related to the polyphenol richness of the environmental vegetation. CYP4s may thus be considered as possible molecular markers in aquatic environmental bioreporting.
A simple method for the synthesis of nanosized Ti3AlC2 powder in NaCl–KCl molten salt

ABSTRACT Herein we report, a simple novel method to synthesize nanosized Ti3AlC2 powder from Ti, Al, and C powders in NaCl–KCl molten salt. It is more conducive to the formation of Ti3AlC2 at higher salt/precursor materials ratio and particle size of Ti3AlC2 powder dramatically decreases with increasing mass ratio of the salt to precursor materials. Fine-grained Ti3AlC2 powder is successfully synthesized at 950○C for 5 h or at 1000○C for 2 h with a salt/precursor materials ratio of 10:1. Ti3C2 MXene is also prepared by etching fine-grained Ti3AlC2 precursor in HF solution at 60°C for 2 h. GRAPHICAL ABSTRACT IMPACT STATEMENT It is the first time that nanosized ternary carbide Ti3AlC2 powder has been synthesized by a simple, high efficiency and relatively low-temperature process.
Robot-mounted through-wall radar for detecting, locating, and identifying building occupants

We have assembled programmed, and demonstrated a robot-mounted motion-detection radar suitable for through-wall operation. Our radar, which employs of pulse-Doppler techniques, is designed to look through building walls and locate moving targets. The radar's signal-processing algorithms use both time-domain and frequency-domain clues to classify detected motion as arising from: (1) the ambient background; (2) mechanical motion; or (3) human activity. In the case of human motion, our routines also attempt to identify the occupant's particular activity, e.g., resting, walking, talking.
A Single-Phase Grid-tied PV based Trans-Z-Source Inverter Utilizing LCL filter and Grid Side Current Active Damping

As grid-connected Photovoltaic (PV) based inverters are being used more, these systems play a more important role in the electricity generation by distributed power generators. Power injection to the grid needs to meet predefined standards. In this work, a PV based inverter consist of a Trans-Z-Source network performing as DC-DC power conversion level, is connected to the grid through a LCL filter. The connection through an LCL filter offers certain advantages, but it brings also the disadvantage of having a resonance frequency. A systematic mathematical design procedure for PR controller parameters along with active damping factor is presented and the overall control system leads to a considerably low value of grid current THD. Meanwhile the Maximum Power Point Tracking (MPPT) of the PV arrays is obtained by a modified INC method. Simulations in various conditions are carried out in MATLAB/Simulink environment and results depict suitable performance of the system with designed parameters.
La perspective temporelle, l’âge et l’investissement en produits bancaires d’épargne par les consommateurs adultes

L’objet du present travail est d’etudier les influences respectives de la perspective temporelle et de l’âge sur l’acquisition de produits bancaires d’epargne ; et de procurer aux institutions bancaires une comprehension profonde du comportement d’investissement du consommateur adulte. Les enjeux sont de taille vu que le consommateur adulte constitue une cible fructueuse et permanente pour le marche des produits d’epargne, mais que paradoxalement, l’epargne des menages souffre d’une baisse et d’une optique a court terme. A ce titre, il s’agit de comprendre les motivations du consommateur adulte en termes d’epargne et de lui proposer des produits qui permettent de satisfaire ses besoins a differents stades de sa vie. Nos resultats montrent que differentes facettes de la perspective temporelle influencent l’acquisition de produits d’epargne et que l’âge joue un role moderateur.
Fungal morphology and fragmentation behavior in a fed-batch Aspergillus oryzae fermentation at the production scale.

It is well known that high-viscosity fermentation broth can lead to mixing and oxygen mass transfer limitations. The seemingly obvious solution for this problem is to increase agitation intensity. In some processes, this has been shown to damage mycelia, affect morphology, and decrease product expression. However, in other processes increased agitation shows no effect on productivity. While a number of studies discuss morphology and fragmentation at the laboratory and pilot scale, there are relatively few publications available for production-scale fungal fermentations. The goal of this study was to assess morphology and fragmentation behavior in large-scale, fed-batch, fungal fermentations used for the production of protein. To accomplish this, a recombinant strain of Aspergillus oryzae was grown in 80 m(3) fermentors at two different gassed, impeller power-levels (one 50% greater than the other). Impeller power is reported as energy dissipation/circulation function (EDCF) and was found to have average values of 29.3 +/- 1.0 and 22.0 +/- 0.3 kW m(-3) s(-1) at high and low power levels, respectively. In all batches, biomass concentration profiles were similar and specific growth rate was < 0.03 h(-1). Morphological data show hyphal fragmentation occurred by both shaving-off of external clump hyphae and breakage of free hyphae. The fragmentation rate constant (k(frag)), determined using a first-order model, was 5.90 and 5.80 h(-1) for high and low power batches, respectively. At the end of each batch, clumps accounted for only 25% of fungal biomass, most of which existed as small, sparsely branched, free hyphal elements. In all batches, fragmentation was found to dominate fungal growth and branching. We speculate that this behavior was due to slow growth of the culture during this fed-batch process.
Identification of Trace Sterols in the Seeds of Foxtail Millet (Setaria italica Beauv.).

Trace sterols in the seeds of foxtail millet (Setaria italica Beauv.) were investigated by GC-MS. Eleven of these trace sterols, i.e., brassicasterol, episterol, 24-methyllathosterol, 24-ethyllathosterol, avenasterol, 24-methylenecholesterol, fucosterol, isofucosterol, 24-methyl-5α-cholest-24(28)-en-3β-ol, 24-ethyl-5α-cholest-24(28)Z-en-3β-ol, and 24-ethyldesmosterol, were identified, suggesting that the previously reported high content of sitostanol was possibly contaminated with a small amount of isofucosterol.
First-principles study of the hexahalogenotechnetate ( IV ) ions TcX 2 6 [ X = Cl , Br ]

We report all-electron scalar relativistic calculations of the structural and electronic properties of the octahedral hexahalogenotechnetate(IV) ions TcX 6 [X = Cl, Br] using spin-polarized density functional theory. The calculated bond distances are in good agreement with X-ray diffraction (XRD) and extended X-ray absorption fine structure (EXAFS) data available for salts of hexachloride and hexabromide technetate ions. Molecular-orbital analysis shows the importance of the hybridization between Tc 4d orbitals and p orbitals of the ligands. Normal modes of vibration of the hexachloride and hexabromide complexes of Tc and Re have also been computed and assessed by comparison with spectral data for salt crystals of technetate/rhenate complex ions. 2010 Elsevier B.V. All rights reserved.
Development and validation of knowledge management performance measurement constructs for small and medium enterprises

Purpose – This paper aims to address the lack of previous studies and to propose a reliable and valid knowledge management performance measurement (KMPM) model for small and medium enterprises (SMEs). Design/methodology/approach – A survey instrument containing 13 constructs and 49 items was initially developed and posted to small and medium-sized consultancy firms in Malaysia. Reliability and validity analysis was performed to ensure the quality of the instrument. Findings – The developed survey instrument was shown to be reliable, valid and suitable to be applied in SMEs to evaluate their knowledge management (KM) performance. Research limitations/implications – The present study is limited to SMEs in the service sector. The results are not suitable to be generalized to the manufacturing sector or larger organizations without further research. Practical implications – This study would provide SMEs with a better understanding on KMPM and also a guideline to refer to when measuring their KM performance. A.
[Expression of Gal-3 and CD82/KAI1 proteins in non-small cell lung cancer and their clinical significance].

OBJECTIVE To study the expression of galectin 3 (Gal-3) and CD82/KAI1 proteins in non-small cell lung cancer (NSCLC) and the correlation between their expression and clinical significance. METHODS The expression of Gal-3 and CD82/KAI1 proteins was detected by immunohistochemistry in 160 specimens of NSCLC and 20 specimens of normal lung tissue. RESULTS The positive rates of Gal-3 and CD82/KAI1 proteins in the NSCLC were 63.8% and 37.5%, respectively, the positive rates of Gal-3 and CD82/KAI1 proteins in the normal lung tissue were 25.0% and 95.0%, respectively, and there was a significant difference between the two groups (P < 0.01). The expression of Gal-3 and CD82/KAI1 proteins was significantly correlated with the grade of tumor, lymph node metastasis, and pathological-TNM stages (all P < 0.05). Spearman analysis showed that there was a negative correlation between expressions of Gal-3 and CD82/KAI1 in NSCLC (r = -0.732, P < 0.01). Overexpression of Gal-3 and low expression of CD82/KAI1 were related to poor prognosis: the survival rate was significantly lower in the positive Gal-3 group (survival time: 23.0 ± 17.5 months) than that in the negative group (survival time: 71.6 ± 21.6 months) (P < 0.01). The survival rates of the CD82/KAI1-positive group (survival time: 72.5 ± 19.5 months) and CD82/KAI1-negative group (survival time: 21.6 ± 16.1 months) were significantly different (P < 0.01). Multivariate analysis indicated that pTNM stage and positive expression of Gal-3 and CD82/KAI1 are independent prognostic factors of NSCLC (P < 0.01). CONCLUSIONS The expression of Gal-3 and CD82/KAI1 may be related to the initiation, development and metastasis of NSCLC. Combined detection of Gal-3 and CD82/KAI1 has an important role in predicting the progression and prognosis of NSCLC.