Miracle-dz/UniFAR-FTUs huggingface dataset:
Mod´ elisation, Estimation et Optimisation de la consommation des interconnexions dans les SOC

Les SOC d'aujourd'hui sont de plus en plus complexes et rec-quierent donc beaucoup de ressources de calcul; ce qui impli queun fort volume de donne´es a stocker en me´moire ou a commun i-quer entre les unite´s de calcul. Pour transmettre ces donn´ ees entreles unite´s (me´moires, processeurs .) des bus ou des re´s eaux surpuce sont utilise´s.Dans les SOC actuels, la consommation due aux interconnexio nspeut repre´senter jusqu'a 50%de laconsommation totale de lapuce[1]. De plus, la re´duction des dimensions des transistors e t des lspose un proble me de plus en plus important au niveau du temps depropagation et de l'e´nergie dus aux interconnexions [2]. Beaucoup de travaux, a diffe´rents niveaux d'abstraction autour del'optimisationde laconsommation desinterconnexions ont e´te´pro-pose´s. Malheureusement, la plupart des techniques d'opti misationpropose´es dans la litte´rature ne sont plus efcaces en ter me dere´duction delaconsommation. Ceciestduaufaitque leslo ngueursd'interconnexion que l'on trouve actuellement dans les SOC sontplus courtes qu'avant. Il devient donc indispensable de pre ndre encompte la consommation des interconnexions lors de l'e´val uationde la consommation d'une puce. Pour ce faire il est ne´ce´ssa ired'utiliser des outils d'estimation de la consommation des i ntercon-nexions lors des premie res phases de l'e´laboration d'un s yste me. Ileste´galement ne´ce´ssaire deproposer de nouvelles techn iques d'op-timisation de la consommation des interconnexions re´pond ant auxspe´cicite´s des interconnexions actuelles.La suite de cet article pre´sentera dans un premier temps les pa-rame tresa prendreencomptelorsdelamode´lisation(de´ laietconsom-mation) des interconnexions, ainsi que les mode les de cons omma-tion de´veloppe´s. La troisie me partie pre´sentera les r´ esultats expe´ri-mentaux obtenus sur l'e´valuation des techniques de re´duc tion de laconsommationa l'aidedel'outil.Base´esurlesre´sultat sexpe´rimentauxcette partie proposerae´galement les pistesa suivre pour les optimi-sations futures.
Expansions of geometries

Abstract For n < ω, expand the structure (n, S, I, F) (with S the successor relation, I, F as the initial and final element) by forming graphs with edge probability n −α for irrational α, with 0 < α < 1. The sentences in the expanded language, which have limit probability 1, form a complete and stable theory.
Delayed gastric emptying and gastric autoimmunity in type 1 diabetes.

OBJECTIVE Delayed gastric emptying and/or gastrointestinal symptoms occur in 30-50% of diabetic patients. Known contributing factors are autonomic neuropathy and acute hyperglycemia, but the role of gastric autoimmunity has never been investigated, although 15-20% of type 1 diabetic patients exhibit parietal cell antibodies (PCAs). We studied gastric motility in diabetes in relation to PCA status, autonomic nerve function, HbA(1c), thyroid-stimulating hormone (TSH), Helicobacter pylori (HP), acid production, and gastric histology. RESEARCH DESIGN AND METHODS Gastric emptying of solids and liquids (measured by (13)C-octanoic acid and (13)C-glycine breath tests, respectively) was tested in euglycemic conditions in 42 type 1 diabetic patients (male/female: 29/13; 15 PCA+; mean age 40 +/- 15 years; mean HbA(1c) 7.8 +/- 0.9%). Gastrointestinal symptoms, autonomic nerve function (Ewing tests), PCA status (indirect immunofluorescence), gastric histology, and acid secretion (pentagastrin) were assessed. RESULTS Solid gastric emptying was delayed in 40% and liquid emptying in 36% of patients. Gastric motility did not correlate with symptoms. PCA status, gastric morphology, and acid secretion were similar in those with and without gastroparesis. HbA(1c) level (beta = 1.34, P = 0.011) was the only risk factor for delayed solid emptying in a logistic regression model testing HbA(1c), autonomic nerve function, PCA, HP status, age, sex, diabetes duration, and TSH. Half-emptying time for liquids correlated with TSH level (r = 0.83, P < 0.0001) and autonomic neuropathy score (r = -0.79, P = 0.001). CONCLUSIONS We found that approximately 50% of type 1 diabetic patients studied had delayed gastric emptying that did not correlate with symptoms. Gastric autoimmunity did not contribute to diabetic gastroparesis. Metabolic control was worse in patients with delayed solid emptying.
Clinical outcomes in patients treated for coronary in-stent restenosis with drug-eluting balloons: Impact of high platelet reactivity

Background The impact of high platelet reactivity (HPR) on clinical outcomes after elective percutaneous coronary interventions (PCI) with drug-eluting balloons (DEB) due to in-stent restenosis (ISR) is unknown. Objective We sought to evaluate the prognostic importance of HPR together with conventional risk factors in patients treated with DEB. Methods Patients treated with DEB due to ISR were enrolled in a single-centre, prospective registry between October 2009 and March 2015. Only patients with recent myocardial infarction (MI) received prasugrel, others were treated with clopidogrel. HPR was defined as an ADP-test >46U with the Multiplate assay and no adjustments were done based on results. The primary endpoint of the study was a composite of cardiovascular mortality, MI, any revascularization or stroke during one-year follow-up. Results 194 stable angina patients were recruited of whom 90% were treated with clopidogrel. Clinical characteristics and procedural data were available for all patients; while platelet function testing was performed in 152 subjects of whom 32 (21%) had HPR. Patients with HPR had a higher risk for the primary endpoint (HR: 2.45; CI: 1.01–5.92; p = 0.03). The difference was primarily driven by a higher risk for revascularization and MI. According to the multivariate analysis, HPR remained a significant, independent predictor of the primary endpoint (HR: 2.88; CI: 1.02–8.14; p = 0.04), while total DEB length and statin treatment were other independent correlates of the primary outcome. Conclusion HPR was found to be an independent predictor of repeat revascularization and MI among elective patients with ISR undergoing PCI with DEB.
Genetic metamorphosis of herpes simplex virus-1 into a biological therapeutic for human cancer

Over the past decade, rapid progress has been made in engineering safe, replicating herpes simplex virus-1 (HSV-1) mutants for use as biological oncolytic agents in the treatment of human cancer. While initial efforts demonstrated the potential of HSV-1 mutants as antitumour agents, they relied on viruses that were not sufficiently attenuated. Following its identification as the major viral neurovirulence determinant, mutations in the γ34. 5 gene were subsequently incorporated into oncolytic strains. Despite the fact that γ34. 5 mutant derivatives can be safely administered to mice, non-human primates and humans, their efficacy is limited because, like many weakened viral strains, they replicate poorly in a number of cell types, including cancer cells. Strategies to improve the oncolytic properties of γ34. 5 mutant derivatives through further genetic manipulation are reviewed. In addition, traditional treatment modalities that incorporate viral inoculation, along with efforts to elicit an antitumour immune response following treatment with γ34. 5 derivatives, are discussed.
A Unique Set of Interactions: The MSU Sustained Partnership Model of Nurse Practitioner Primary Care

Purpose To present a unified conceptual model that identifies the integral processes of nurse practitioner (NP) care delivery and that integrates major structural influences and potential outcomes. The model is further characterized to delineate the unique and “value‐added” nature of NP primary care and to describe how this nature may be correlated with specific clinical outcomes. Data Sources Extensive review of the literature, relevant conceptual models, clinical experiences of the authors, and two sets of qualitative data exploring differences between NP practice and other practices. Conclusions The basis of NP primary care is the unique provider‐client relationship that develops within the primary care setting. This relationship is oriented toward (a) helping clients become empowered to more appropriately manage their own care in a way that will best meet their needs, (b) encouraging mutual decision making, (c) ensuring clients’ continuity of care, and (d) providing a holistic approach to primary care. The major structural influences are NP role components, interdisciplinary practice relationships, budget resources and payer mix, and environmental characteristics. The potential outcomes are increased healthpromoting behaviors, improved utilization of care, higher client satisfaction levels, and improved health status. Implications for Practice NPs can use this model to articulate the unique contribution of NP practice and its interrelationships within the broader primary care setting. Practicing NPs can use this framework to better understand the complexities of their current and future primary care practices. Faculty can utilize the concepts to help guide students’ understanding of their prospective roles as advanced practice nurses. Finally, this conceptual framework can inform research about specific NP processes and related outcomes. A clearly delineated model that accurately depicts structures, processes, and outcomes relevant to NP primary care can strengthen NP education, distinguish NP practice, and advance evidenced‐based research linking NP practice and outcomes.
Cascadability study for optical label swapping using synchronous phase modulation

We experimentally investigate the cascadability of optical label swapping using a synchronous phase modulation technique without wavelength conversion in a recirculating loop to emulate multihop networks. We find that the power penalties for both label and payload are below 1 dB at 10-7 bit-error rate after five hops. We also show that a system penalty can be maintained below 1 dB for an accumulated timing mismatch of 20% of bit period using synchronous phase modulation-based optical label swapping. The results show the potential to save up to 80% of wavelength converters in optical packet switched networks applications
Cooling history of Atlantis Bank oceanic core complex: Evidence for hydrothermal activity 2.6 Ma off axis

We report 26 (U‐Th)/He zircon ages from Atlantis Bank, Southwest Indian Ridge, which constrain time scales and rates of lower crustal cooling in ultraslow spreading oceanic crust in this setting. Samples from the detachment fault surface indicate that denuded oceanic crust cooled rapidly (<1 Ma), yielding cooling rates >1200°C/Ma, consistent with existing models for the cooling of oceanic crust. (U‐Th)/He zircon ages from samples collected along N–S and E–W trending faults scarps record young ages inconsistent with standard cooling models for lower oceanic crust. These samples have a mean (U‐Th)/He zircon age 2.6 Ma younger than their corresponding igneous crystallization ages and record cooling through 200°C well outside the rift valley. Similar anomalously young ages are recorded by zircon, sphene, and apatite fission track data from ODP Hole 735B. We interpret these young ages as recording an off‐axis thermal/heating event associated with localized high‐temperature (>300°C) hydrothermal fluid flow resulting from underplated mafic magmas.
Sobrecarga de ferro transfusional em portadores de anemia falciforme: comparação entre ressonância magnética e ferritina sérica * Transfusional iron overload in patients with sickle cell anemia: comparison between magnetic resonance imaging and serum ferritin

bioquímicos Materiais 32 portadores anemia falciforme, submetidos magnética fígado. sequências gradiente-eco spin-eco. intensidade sequência pelas médias regiões interesse fígado musculatura razão intensidade (RIS) fígado/músculo. hepática estimada ferro (CHEF) Objective: To identify predictive variables of iron overload in patients with sickle cell anemia, correlating biochemical and imaging markers. Materials and Methods: The authors developed a cross-sectional study involving 32 patients with sickle cell anemia who were evaluated for ferritin and iron serum levels and submitted to liver magnetic resonance imaging with one spin-echo and five gradient-echo sequences. The signal intensity was obtained at each sequence, corresponding to the arithmetical mean of the measurements on regions of interest in the liver and paraspinal muscles to obtain the liver/muscle signal intensity ratio (SIR). Based on such SIR, the liver iron concentration (LIC) was estimated by means of the following formula: e [5.808 (0.877 – (1.518 × IW)] , where T2* is the SIR on the sequence with echo time = 13 ms and IW is the SIR on the intermediate-weighted sequence. Patients were grouped according to their blood transfusion regimen (regular monthly versus sporadic transfusions). Results: The comparison between the transfusion groups was based on clinical-laboratory variables, with significant differences in SIR, LIC and serum ferritin levels: the group with regular transfusions demonstrated greater hepatic iron overload. Conclusion: Magnetic resonance imaging is an efficient tool for evaluating liver iron overload in patients with sickle
Smartphone Assisted Language Learning and Autonomy

In the present study we investigate the advantages of using smartphones in an English as a foreign language EFL classroom. We compared two groups of Japanese university students who were either prohibited from using their smartphones in the classroom, or encouraged to use them for academic purposes, examining whether those using smartphones in their EFL lessons would show a tendency toward being autonomous. The results indicated that students who were encouraged to use their smartphones during class were inclined to study more in their free time as well as show signs of autonomy by taking charge of their learning and consider ways to improve their own study habits and English proficiency. Our conclusion is that language teachers and learners should be encouraged to use smartphones in the classroom as a means of fueling the desire to learn.
Professional Quality of Life of Veterans Affairs Staff and Providers in a Patient-Centered Care Environment

Changes to the work environment prompted by the movement toward patient-centered care have the potential to improve occupational stress among health care workers by improving team-based work activities, collaboration, and employee-driven quality improvement. This study was conducted to examine professional quality of life among providers at patient-centered care pilot facilities. Surveys were conducted with 76 Veterans Affairs employees/providers at facilities piloting patient-centered care interventions, to assess demographics, workplace practices and views (team-based environment, employee voice, quality of communication, and turnover intention), and professional quality of life (compassion satisfaction, burnout, and secondary traumatic stress). Professional quality-of-life subscales were not related to employee position type, age, or gender. Employee voice measures were related to lower burnout and higher compassion satisfaction. In addition, employees who were considering leaving their position showed higher burnout and lower compassion satisfaction scores. None of the work practices showed relationships with secondary traumatic stress.
The effect of Sterilex Ultra for disinfection of dental unit waterlines.

AIM To evaluate the effect of a disinfectant agent based on hydrogen peroxide (Sterilex Ultra, Sterilex Corporation, Maryland, USA) on the microbiological water quality in dental unit waterlines (DUWL). SETTING Six older dental units were disinfected with Sterilex Ultra and another six units with sodium hypochlorite. The results were compared to six non-disinfected units examined during a period without patient treatment. OUTCOME MEASURE The number of colony forming units of bacteria (cfu)/ml of water was determined according to European Standards on water quality. DESIGN The water quality was initially determined during a six week period, and subsequently in more detail for two weeks. Finally, the effect of prolonged administration of Sterilex Ultra was investigated for six weeks. RESULTS Instillation of Sterilex Ultra according to the recommendations of the manufacturer initially reduced the number of bacteria in DUWL to <10(2) cfu/ml. However, following daily, as well as prolonged administration of Sterilex Ultra a gradual recolonisation was observed resulting in bacterial numbers >10(4) cfu/ml in a number of units. Major differences between the number of cfu/ml in individual units were observed. CONCLUSION Neither daily nor extended administration of Sterilex Ultra was capable of maintaining an acceptable water quality in these older dental units.
Mycotoxins in aquaculture: Occurrence in feeds components and impact on animal performance

In the last years there is a trend to replace fish meal as a source of protein by less expensive sources of protein from plant origin. As a result of this trend, aquaculture feeds have a higher risk of being contaminated with one or more types of mycotoxins. Mycotoxins are secondary metabolites produced by fungi and highly toxic to animals. Despite the limited number of studies on the effect of mycotoxins on aquaculture species, there is increasing evidence that mycotoxins can cause several pathologies and growth problems in different fish and shrimp species. A recent survey on the occurrence of mycotoxins in feed components showed that analyzed samples from different regions were contaminated with one (74%) or more (40%) mycotoxins. Despite good screening programs, selection of high quality raw materials and feed ingredients and good storage conditions it is very difficult to guarantee the absence of mycotoxins in aquaculture feeds. Therefore it is urgent to find suitable ways to face the problem through an effective management of the risks posed by mycotoxins contaminations. The current paper presents an overview of the effects of mycotoxins on fish and shrimp performance and the occurrence of these mycotoxins in feed components.
The impact of shown emotions by an ECA on a subject in an iterated prisoner's dilemma

The goal of this research was to test if there is an impact of shown emotions by an ECA on a human being (subject) in an iterated prisoner’s dilemma. To answer this question, a literature study has been done on the different aspects of trust. These aspects contributed on building a relation of trust between the ECA and the subject. After this relation of trust has been established, the impact of different emotions on the subject has been tested. The experiment, which is a game, has been done by 43 people. The experiment showed no significant impact of the shown emotions by an ECA on a subject in an iterated prisoner’s dilemma. This has been tested by a statistical analysis on the results of the experiment. Although a relationship has not been found between the shown emotions and the actions taken by a subject in an iterated prisoners dilemma, it does not mean there is no relation. Further research should be done on this relation.
Personalisation of Therapy – clinical impact and relevance of genetic mutations in tumours

As technological advances in genetic sequencing and the parallel reduction in costs of sequencing make testing more accessible, genomic profiling of tumours is increasingly becoming integrated into routine clinical care. This personalisation of medical care is especially relevant in the area of oncology, where interest in tumour testing as part of standard care has dramatically increased. Tumour genomic profiles are particularly interesting, as they harbour mutations acquired temporally as somatic events, and less commonly, may reveal defects that have been inherited through the germline. Numerous techniques can be utilised to interrogate the tumour genomic landscape, ranging from tried and tested techniques, such as karyotyping, to full mutational analysis using more modern next and third generation technologies. The challenge for the clinician is no longer predominantly in accessing genomic technologies, but rather in interpreting complex reports, and separating relevant clinically actionable mutations from incidental mutations reflective of the damaged DNA repair mechanisms that are intrinsic to the neoplastic process. This may be especially difficult if the mutational spectrum includes variants in less well-studied genes, or in genes not commonly implicated as drivers of the cancer under investigation. Increasing utilisation of genomic profiling of cancers has informed our understanding that the timing of a mutation in a particular gene is as relevant as the gene in which it occurs in determining the neoplastic course. Once the key driver mutations in a cancer have been identified, the next challenge is to find and utilise an appropriate agent that targets the specific defect. Many hundreds of targeted agents have been designed and put through rigorous in vitro and phase 1 or even phase 2 trials, but few have made it into routine clinical use to date. In this review, we discuss the underlying mechanisms of genomic changes and mutational signatures that can be potentially targeted for therapeutic benefit, and some successful targeted agents that have been developed to date.
Energy efficiency performances of selective switch OFF algorithm in LTE mobile networks

Energy efficiency is one of main challenges for the evolution of mobile networks. Many solutions have been already proposed by literature studies, and one promising technique is given by selective switch OFF schemes applied to booster cells in presence of a coverage layer. This mechanism permits to save energy by dynamically switching off redundant cells in conditions of low traffic, while maintaining the minimum QoS requested in the network. Nevertheless, in order to evaluate the real gains achievable by the operator in terms of decrease in energy consumption, these theoretical solutions should be implemented in a real network; from this point of view, ON-OFF algorithms in literature often result not suitable for a real implementation because of practical constraints and hardware capabilities of commercial equipment. The real performances of a selective switch OFF scheme have been assessed in a test bench with real eNodeB LTE in an opportune scenario of interest and with commercial terminals. Achieved gains obtained in high traffic conditions are encouraging also to open research activity in order to have future sustainable mobile communication systems.
Identification of Gremmeniella abietina Races with Random Amplified Polymorphic DNA Markers

Seven random amplified polymorphic DNA (RAPD) markers amplified from four oligonucleotides (10-mers) by the polymerase chain reaction were used to distinguish between the North American and European races of Gremmeniella abietina, the causal agent of Scleroderris canker of conifers. Forty-three isolates of the pathogen from 11 different host species originating from 11 countries, states, and provinces were tested; race designation was consistent with results from immunogenic and soluble-protein assays. By using RAPD markers, it was possible to identify G. abietina races by DNA amplifications directly from fruiting bodies, thus eliminating the need to culture the fungus, as is necessary with immunogenic and soluble-protein assays. Two isolates which had been previously classified as intermediate were clearly identified as belonging to either one of the two races by using RAPD markers. No interracial hybrids were detected in our survey. Patterns of amplification products from the European race in North America were identical to patterns of European isolates, further substantiating that this is an introduced race to the North American continent.