Miracle-dz/UniFAR-FTUs huggingface dataset:
Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia.

There are no effective therapeutics for cognitive impairments associated with schizophrenia (CIAS), which includes deficits in executive functions (working memory and cognitive flexibility) and episodic memory. Compounds that have entered clinical trials are inadequate in terms of efficacy and/or tolerability, highlighting a clear translational bottleneck and a need for a cohesive preclinical drug development strategy. In this review we propose hippocampal-prefrontal-cortical (HPC-PFC) circuitry underlying CIAS-relevant cognitive processes across mammalian species as a target source to guide the translation-focused discovery and development of novel, procognitive agents. We highlight several G protein-coupled receptors (GPCRs) enriched within HPC-PFC circuitry as therapeutic targets of interest, including noncanonical approaches (biased agonism and allosteric modulation) to conventional clinical targets, such as dopamine and muscarinic acetylcholine receptors, along with prospective novel targets, including the orphan receptors GPR52 and GPR139. We also describe the translational limitations of popular preclinical cognition tests and suggest touchscreen-based assays that probe cognitive functions reliant on HPC-PFC circuitry and reflect tests used in the clinic, as tests of greater translational relevance. Combining pharmacological and behavioral testing strategies based in HPC-PFC circuit function creates a cohesive, translation-focused approach to preclinical drug development that may improve the translational bottleneck currently hindering the development of treatments for CIAS.
Suicidal behavior is four times more frequent in university students with bipolar disorder assessed by an online version of Mood Disorder Questionnaire

Introduction: Bipolar disorder (BD) in young people is frequently associated with suicidal behavior. The main objective of this research is to evaluate if university students who have BD show more suicidal behavior than those who do not have BD. Materials and Methods: 583 university students from Fortaleza, Brazil, participated in this study. Volunteers over 18 years of age who were attending public or private universities from March to December 2019 were able to participate. A sociodemographic and clinical questionnaire and the Mood Disorder Questionnaire (MDQ) were filled out. According to MDQ, participants were classified into three groups: 1) individuals without BD (n=318); 2) individuals with subthreshold BD symptoms (n=160); 3) individuals with BD (n=105). Results: Compared to those who do not have BD, individuals with BD had four times less plans for the future (x2=16.00; p=0.000), considered four times life less worth living (x2=13.44; p=0.001), assumed two times more frequently death as welcome if it comes (x2=19.10; p=0.000), thought two times more about getting hurt (x2=75.32; p=0.000), had seven times more specific plans to die (x2=39.93; p=0.000) and had four times more suicide attempts (x2=33.50; p=0.000). Conclusions: Suicidal behavior was four times more prominent in university students with BD than in those who did not have BD.
Seed dormancy removal treatments and germnaton characterstcs of Acer trautvetteri Medvedev seeds

In this study, seed dormancy removal and germination characteristics of Acer trautvetteri Medvedev, is one of the major maple species of the eastern Black Sea region, were studied. To do that, the seeds were collected in 2008 three times with aproximately 15-days intervals. In order to remove dormancy, several germination treatments were applied. The treatments were (1) different seed collection time, (2) soaking in water, (3) cold-moist stratification and (4) GA3 (gibberellic acid) application. The treated seeds were germinated in growing chamber at 5 0C and in greenhouse conditions. This research indicated that seeds of Acer trautvetteri exhibit physiological dormancy and require stratification period to remove seed dormancy. The highest germination percentage in the growing chamber subjected to GA3 application after eight weeks of stratification treatment was 66 % for Acer trautvetteri seeds. The highest germination percentage in greenhouse was obtained with cold stratification after eight weeks (81 %). Although GA3 treatment had a positive effect on germination in growth chamber + 5 0C, GA3 treatment had a negative effect on germination in greenhouse conditions. Soaking in water of nonstratified seeds wasn’t any significant difference on seed germination. There was a positive correlation between seed collection time and germination (r=0.59). As a result, the third collection time (in october) should be preferred as seed collection time in Acer trautvetteri seeds, considering that it may vary according to the climatic conditions of the year.
Procedimiento para el análisis biomecánico de la variabilidad del movimiento en el lanzamiento de disco

The analysis on the technique of the sport movements from the study of the variability of the movement is a new approach to the evaluation, diagnosis and control of the sport techniques. It was known of the existence of diverse investigations on the technique of the Launching of the Disk, however these they have not focused their analyses from the variability; neither they have offered procedures to make the analysis from this perspective. The objective of this paper is: to establish a procedure for the study of the variability of the technique in the Launching of Disk. The study was centered in a case of the masculine sex that has 15 years and that it trains Launching of the Disk in the School of Initiation Sport Scholar of Villa Clara. Cuba. As the research methods of the theoretical and empiric level were used as the study of cases, the study of the Biomechanics and the statistical-mathematical analysis. it is possible to verify that single two parameters showed high variability in the 9 made launchings, while the rest if it achieves a deviation standard smaller and therefore little variability in the movements, also, a high satisfaction of the users existed with the used procedure. The index obtained when applying the technical IADOV indicates that the introductory users' satisfaction exists with the certain indicators.
Working Capital Management Impact on Economic Value Addition of the Poultry Industry in Nigeria

The poultry industry as a key player under the category of Small and Medium-Sized Enterprises (SMEs) in the Agricultural sector makes critical use of the component of working capital and their contribution to the economy of the country is a direct variable of the value addition generated.The efficiency and judicious utilisation of the key components of the working capital components combined with the peculiarity and uncertainties associated with the Nigerian business environment can make or mar the success of such SMEs operating in the poultry industry and this is a focus of this study. The study employed survey design with cluster sampling approach. The study population is made up of Poultry farmers in 162 farms as registered with the Poultry Association of Nigeria-Ogun State Chapter with the total of 200 farm managers, this number exclude farm attendants and other non-managerial staff as they are task staff . The Cochran formula was used to obtain a sample size of 150. The owners/managers and other participants in these farms were selected through a multi-stage sampling technique which involves the stratified, proportionate, and simple random sampling method. The instrument validity was done through scrutiny and evaluation by the research supervisors and experts in the study area, and reliability was determined via Cronbach’s alpha coefficient computed from pilot study responses. By the use of instrument codes, responses were processed into quantitative data for descriptive and empirical analysis. The analysis revealed that all proxies of working capital management practices such as cash management, accounts receivable management, accounts payable management and inventory management have a significant positive effect on economic value addition of the poultry industry (Adjusted R2= 0.057, F-statistics = 2.485.: p= 0.035<0.05). Thus, the study concluded that working capital management proxies, of cash management, accounts receivable management, accounts payable management and inventory management, has a significant positive effect on the economic value added of poultry industry in Ogun State, Nigeria.
A biosensing platform for sensitive detection of concanavalin A based on fluorescence resonance energy transfer from CdTe quantum dots to graphene oxide

In this paper, we constructed a novel fluorescence resonance energy transfer (FRET) system between CdTe quantum dots (QDs) and graphene oxide (GO) for sensitive detection of concanavalin A (Con A). In this system, CdTe QDs as an energy donor and GO as an energy acceptor were both covalently functionalized by glucosamine via an amide linkage. The specific combination of Con A with glucosamine could bring CdTe QDs and GO into appropriate proximity and therefore induce efficient energy transfer. The concentration of Con A caused modulation of the energy transfer efficiency between GO and QDs, thus enabling Con A detection. Under the optimized experimental conditions, the decrease of fluorescence intensity ratio I/I0 (I0 and I are the fluorescence intensity of the sensing system in the absence and presence of Con A, respectively) is proportional to the concentration of Con A in the range of 9.8–196.1 nM. This method has high sensitivity with the detection limit as low as 3.3 nM. The results suggested that the graphene FRET platform could be used for sensitive and selective sensing of Con A and could be applied for protein–carbohydrate interaction studies.
Do e-athletes move? A study on physical activity level and body composition in elite e-sports

Purpose: The aim of this study is to determine the effect of e-sports on physical activity level and body composition. Material: The athletes who participated in the study were 19.92± 2.21 years of age, 1.73±0.04 m body height and 78.35±6.52 kg body weight. A total of 137 athletes participated in the study, including 27 from Turkey, 47 from South Korea and 63 from the United States (USA). The data was collected by e-mail from the sports clubs. The athletes who representing their country in international competitions involved in the study. The data obtained were evaluated in the SPSS program. Results: According to the findings of the study, the body mass index (BMI) of e-sport athletes is 26.03±1.85, the number of physical activity steps is 6646±3400 and the daily e-sport hours are 9.34±1.12. The BMI was determined as USA 26.12, South Korea 26.02 and Turkey 25.84 respectively. The number of physical activity steps was identified as 5255 steps in the US, 7785 steps in South Korea and 7909 steps in Turkey. The daily e-sports hour is set at US 9.63 hours, Turkey 9.29 hours and South Korea 8.97 hours. In comparison of country-based athletes, there was a significant difference between physical activity level and daily e-sports hours at p<0.05. The value of BMI is not different. Although it is not statistically related to the physical activity level and BMI. There was no statistically significant relationship between daily e-sports hours and BMI and physical activity step counts. However, as the time of e-sports increases, BMI increases and the number of physical activity steps decreases. Conclusions: As a result it is seen in the findings of the research that athletes dealing with e-sports are included in the fat group as a body composition and their daily physical activity steps are low. In addition, according to the results of the research, e-sports are thought to have negative effects on physical health. Thanks to the physical activity programs to be applied to these athletes, it is thought that their body composition and physical activity levels can be improved.
Urban metabolic system of water for the 21st century

Since human activity is about to outgrow the natural capacity, thus becoming a prominent affector to the environment, an urban/regional water system that minimizes influence on the environment, but at the same time, satisfies the human needs must be considered. This is necessary to keep well being urban/industrial areas side-by-side with the external nature. To address this problem, new systems of water and wastewater treatment as well as new methods of water utilization are coming up. The considerations and issues related to the planning and design of such water systems are discussed in this paper.
Data-driven multichannel poststack seismic impedance inversion via patch-ordering regularization

Seismic acoustic impedance inversion plays an important role in reservoir prediction. However, single-trace inversion methods often suffer from spatial discontinuities and instability due to poor-quality seismic records with spatially variable signal-to-noise ratios or missing traces. The specified hyperparameters for seismic inversion cannot be suitable to all seismic traces and subsurface structures. In addition, conventional multichannel inversion imposes lateral continuity with a prespecified mathematical model. However, the inversion results constrained with specified lateral regularization are inferior when the subsurface situations violate the hypothesis. A data-driven multichannel acoustic impedance inversion method with patch-ordering regularization is introduced, in which the spatial correlation of seismic reflection is used. The method decomposes the seismic profile into patches and constructs the patch-ordering matrix based on the similarity among seismic patches to record the impedance structural extension. So the patch-ordering matrix can record the spatial extension of the acoustic impedance. Then, a simple regularization with difference operators of varying weights can reduce the random noise presented in the inverted impedance profile, stabilize the inversion result, and enhance the spatial continuity of the layer extension. The objective function for multichannel poststack seismic impedance inversion can be constructed by integrating the observed seismic record and the spatial continuity in the form of patch-ordering regularization, and it can be solved effectively with the limited-memory BFGS algorithm. The synthetic and field data tests illustrate the improvement of accuracy and lateral continuity of inverted results with our method, compared to conventional model-based inversion results.
Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification

The Wnt pathway activates target genes by controlling the {beta}-catenin-T-cell factor (TCF) transcriptional complex during embryonic development and cancer. This pathway can be potentiated by R-spondins, a family of proteins that bind RNF43/ZNRF3 E3 ubiquitin ligases and LGR4/5 receptors to prevent Frizzled degradation. Here we demonstrate that, during Xenopus anteroposterior axis specification, Rspo2 functions as a Wnt antagonist, both morphologically and at the level of gene targets and pathway mediators. Unexpectedly, the binding to RNF43/ZNRF3 and LGR4/5 was not required for the Wnt inhibitory activity. Moreover, Rspo2 did not influence Dishevelled phosphorylation in response to Wnt ligands, suggesting that Frizzled activity is not affected. Further analysis indicated that the Wnt antagonism is due to the inhibitory effect of Rspo2 on TCF3/TCF7L1 phosphorylation that normally leads to target gene activation. Consistent with this mechanism, Rspo2 anteriorizing activity has been rescued in TCF3-depleted embryos. These observations suggest that Rspo2 is a context-specific regulator of TCF3 phosphorylation and Wnt signaling.
Full-Scale Implementation of RES and Storage in an Island Energy System

The field of energy, specifically renewable energy sources (RES), is considered vital for a sustainable society, a fact that is clearly defined by the European Green Deal. It will convert the old, conventional economy into a new, sustainable economy that is environmentally sound, economically viable, and socially responsible. Therefore, there is a need for quick actions by everyone who wants to move toward energy-efficient development and new environmentally friendly behavior. This can be achieved by setting specific guidelines of how to proceed, where to start, and what knowledge is needed to implement such plans and initiatives. This paper seeks to contribute to this very important issue by appraising the ability of full-scale implementation of RES combined with energy storage in an island power system. The Greek island power system of Astypalaia is used as a case study where a battery energy storage system (BESS), along with wind turbines (WTs), is examined to be installed as part of a hybrid power plant (HPP). The simulation’s results showed that the utilization of HPP can significantly increase RES penetration in parallel with remarkable fuel cost savings. Finally, the fast response of BESS can enhance the stability of the system in the case of disturbances.
Assessment of Risk Factors of Hypertension among Pakistani People Living in Populated Cities of the Country

The association between diet, age, gender, socioeconomic status, ethnicity and hypertension are well recognized among developing countries. However, the main factors causing hypertension in Pakistan are still not clear. Hypertension is complex and multi factorial. The current article summarizes some of the known factors responsible for hypertension within populated cities of Pakistan. This review was focused on ethnic group of people living within country. Random or multistage screening, socioeconomic status or hypertensive condition was considered during selection of subjects. The dietary patterns in relation with hypertension and other health problems were studied. Studies showed a prominent occurrence among urban adults, particularly women. The Diet transition towards the DASH Diet has been attributed to lower blood pressures. This review highlights the fact that dietary pattern, socioeconomic status, gender, age and obesity is associated with hypertension.
A PHARMACOEPIDEMIOLOGICAL STUDY ON THE SIDE EFFECTS OF INDAPAMIDE

Although thiazide-like diuretics were initially known to have little or no metabolic side-effects, some later evidence showed some of their adverse reactions. We aimed to survey their side-effects in long term administration. We conducted a prospective pharmacovigilance study on the metabolic side-effects of indapamide in the V Internal Medicine Clinic Iași, Romania, between 2016 and 2018. Thirty hypertensive patients were monitored regarding glycaemia, uricemia and kaliemia before starting indapamide administration (T0), after at least three months of administration (T1) and after at least some other three months of withdrawal (T2). A significant increase of glycaemia and uricemia appeared after three months of administration of indapamide, which disappeared in most of the cases after stopping the treatment. A significant decrease of kaliemia was also noted under treatment and it was reversible after stopping indapamide. The incrimination of indapamide in producing hyperglycaemia, hyperuricemia or hypokalaemia was certain or probable in eight cases and possible in five cases according to the WHO-UMC (2010) algorithm for causality assessment. Thiazide-like diuretics may expose to the same metabolic risks as thiazide-type diuretics. Precautious administration in case of already present hypokalaemia could be protective. Larger studies are needed in order to define the dose, the period of administration or other associated factors that could expose to an increased risk of side-effects.
Experiencia del aprendizaje de la Educación Superior ante los cambios a nivel mundial a causa del COVID-19

La experiencia de aprendizaje en la educacion superior se ha visto afectada ante la crisis mundial por el COVID-19. Se ha realizado una encuesta a un grupo de 117 estudiantes y profesores de diferentes universidades de Iberoamerica, donde se ha observado los problemas que se enfrentan los estudiantes para recibir sus clases de manera en linea, el cual puede ser ocasionado por el nivel de conectividad o la ausencia de un equipo tecnologico. A su vez, los mismos estudiantes sienten que las evaluaciones son mas estrictas y duras al evaluar. Por otro lado, los profesores se enfrentan al uso de plataformas tecnologicas para ofrecer sus cursos, evaluar los estudiantes y transmitir las clases. Por lo tanto, hay unas nuevas competencias que deben ser adquiridas para dictar un curso en linea, de tal manera que motive al estudiante durante su aprendizaje.
El Covid-19 y la necrocorrupción del capitalismo neoliberal

El actual desafío global del coronavirus confirma la insostenibilidad de la organización capitalista del mundo. En su fase neoliberal, el capitalismo socava las posibilidades de una sociedad ecológicamente sostenible que se guíe por valores comunitarios abiertos a la vida. Esta destrucción del mundo compartido descansa en procesos de corrupción que se basan últimamente en la modelación capitalista de la subjetividad humana —un proceso que se presta a un análisis teológico político. Así, este proceso corruptivo va más allá del ámbito institucional, para generar una distorsión holística de la praxis humana que se refleja incluso en condiciones sociopáticas. La crisis del Covid-19 puede motivar una acción política de largo alcance que plantee la implementación de cambios paradigmáticos en la sensibilidad global. Esta lucha podría movilizar una matriz comunitaria enraizada en una respetuosa relación humana hacia los otros y la naturaleza.
Contamination of Polyvinyl Chloride Cling Films from Cardboard Packaging

An analytical screening was undertaken with the aim of investigating the occurrence of di‐isobutylphthalate (DIBP) in polyvinyl chloride (PVC) cling films for food contact applications and its source of contamination throughout a converting process. Although raw plastic materials used by producers are free from phthalates and analytical evidences confirm their absence after the extrusion process, DIBP can be found in final rolls packaged into cardboard packaging during storage.
A Multi-Layer Model for Transpiration of Urban Trees Considering Vertical Structure

As the intensity of the urban heat island effect increases, the cooling effect of urban trees has become important. Urban trees cool surfaces during the day via shading, increasing albedo and transpiration. Many studies are being conducted to calculate the transpiration rate; however, most approaches are not suitable for urban trees and oversimplify plant physiological processes. We propose a multi-layer model for the transpiration of urban trees, accounting for plant physiological processes and considering the vertical structure of trees and buildings. It has been expanded from an urban canopy model to accurately simulate the photosynthetically active radiation and leaf surface temperature. To evaluate how tree and surrounding building conditions affect transpiration, we simulated the transpiration of trees in different scenarios such as building height (i.e., 1H, 2H and 3H, H = 12 m), tree location (i.e., south tree and north tree in a E-W street), and vertical leaf area density (LAD) (i.e., constant density, high density with few layers, high density in middle layers, and high density in lower layers). The transpiration rate was estimated to be more sensitive to the building height and tree location than the LAD distribution. Transpiration-efficient trees differed depending on the surrounding condition and plant location. This model is a useful tool that provides guidelines on the planting of thermo-efficient trees depending on the structure or environment of the city.