Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute Ischemic Stroke Treatment: An Emergency A. Organization and Management

The control of health expenditure has become one of the main axes of health policy. Cost studies are an indispensable tool for determining the economic impact of disease and for assigning the material and human resources required for the prevention, diagnosis, treatment, and follow-up of patients with different diseases. Cost studies in stroke are necessary due to the increasing incidence of this disease which represents a significant cause of death and invalidity in adults and produces important hospital and social spending, and for which patients must be treated in specialized units (stroke units). The principal cost-determining factors in most studies are those generated by hospital admission (principally hospital stay). Other cost-determining factors include severity, stroke subtype or the fate of patients on discharge. Future health policies aimed at optimizing economic resources must be directed towards reducing hospital stay and minimizing patient disability. Copyright © 2004 S. Karger AG, Basel Introduction Since the availability of economic resources for the health system is limited, one of the priority objectives of health policy in developed countries is cost control, without compromising the quality of care. The economic repercussions of different diseases depend mainly on their incidence, the severity of their sequelae, and the cost of measures needed for diagnosis, treatment, and follow-up. According to the World Health Organization, stroke represents the second most common cause of death and the principal cause of invalidity in adults [1–3], and in Spain it is the principal cause of mortality due to specific entities in women, according to the data of the National Institute of Statistics. The progressive aging of the population will produce an increase in patients with stroke and, consequently, an increase in health expenditure [4]. In addition, the techniques used for the diagnosis of stroke are costly, treatments administered are for life, and the sequelae caused by cerebrovascular disease in survivors require long-term rehabilitation and occasionally permanent institutionalization. In recent years, the treatment of stroke has changed substantially as a consequence of the indubitable benefit obtained by patients treated in specialized units (stroke units), the surge of innovative diag-
Quantum interference beyond the fringe

The discovery 30 years ago of the interference of pairs of photons signaled the onset of an era for quantum optics Thirty years ago, Len Mandel, together with his students Jeff Ou and C. K. Hong, published a description of a remarkably simple experiment (1), the consequences of which have had dramatic implications for quantum science and technology. The experiment consisted of sending two elementary particles of light, photons, onto opposite sides of a piece of glass that had been coated with a thin film to give it a reflectivity of 50% (see the figure). They observed that the two photons always left by the same side at the output, though it was not possible to determine beforehand which side that would be. This is completely surprising if one considers the behavior of particles as indivisible, identical entities obeying the laws of classical physics. It is easy to see that in such a circumstance, one might expect there to be four equally likely output configurations, only two of which consist of the particles occupying the same outputs. The phenomenon is a beautiful manifestation of the interference of a quantum field; in this case, the bosonic field associated with photons. The effect would be entirely the opposite with fermionic fields associated with electrons—both particles would always leave by different sides.
Multidimensional Mobility Metric for Continuous Gait Monitoring using a Single Accelerometer

Mobility has been measured in the form of gait analysis – a method used to assess the physical functioning of a human. Many health-related clinical and pathological gait analysis applications have been proposed in the last decades. Gait analysis research has been predominantly conducted in laboratories in a discipline-specific manner. The main measurement approach is to monitor intrinsic gait patterns in natural settings such as home or work. Our proposed mobility assessment approach is to assess gait along three major gait dimensions: intensity, symmetry, and variability. This multidimensional metric uses a single accelerometer to assess the three dimensions so that the gait metric is continuously applied to mimic the natural human gait in daily life. Initial experimental results demonstrate its practical use in different gait patterns with various gait speeds.
L'influence du gouvernement d'entreprise et du co-commissariat aux comptes sur la détermination des honoraires d'audit des sociétés cotées françaises

Notre recherche a pour but, en utilisant des information disponibles grâce a la publication des honoraires d'audit par une partie des entreprises cotees francaises, de tester un modele de determinants des honoraires d'audit integrant l'influence des caracteristiques specifiques du co-commissariat aux comptes a la francaise. En accord avec les recherches anterieures, nous controlons que les honoraires d'audit sont positivement lies avec la taille, la complexite de l'entreprise, et la cotation sur un marche anglo-saxon (Londres ou New York). Notre recherche montre que les mecanismes de gouvernement d'entreprise contribuent a renforcer le controle exerce par les auditeurs et que le pourcentage d'administrateurs independants se traduit par une augmentation des honoraires d'audit. Enfin, concernant le co-commissariat aux comptes, nos resultats mettent en evidence une double prime aux BIG 4 dans le contexte francais et confirment que la fourniture de services autres que l'audit entraine une augmentation des honoraires d'audit legaux.
Analysis of the small signal dynamic performance of synchronous generators under unbalanced operating conditions

This work presents a thorough study about the effects of load unbalance in the dynamics of a power system that can be modeled as a single machine (synchronous generator) connected to an infinite bus. The main motivation for such a study is to better understand the behavior of power distribution systems when distributed synchronous generators with such typical topology are present, which is common in several countries around the world, including Brazil. The focus of this paper is the dynamic behavior of the system after small perturbations, as characterized by the system eigenvalues, focusing on the electromechanical oscillation frequencies and damping ratios, as affected by the load unbalance. In this work, other typical characteristics are also analyzed, such as the AVR and PSS gains, when well- or poorly-tuned. All the analysis is done through the estimation of these eigenvalues via a rotational invariant technique (ESPRIT method) from nonlinear simulations performed on ATP.
Provision of care following prevention of mother-to-child HIV transmission services in resource-limited settings

Objective:To evaluate the provision of care for mother and child after institution of prevention of mother-to-child transmission (PMTCT) of HIV services. Design:As part of an effort to improve services, we undertook a review of our multicountry PMTCT program. Methods:Review of key indicators from our PMTCT database and reporting practices from January 2005 to June 2006 throughout 18 resource-limited countries. Results:1 066 606 pregnant women were counseled and tested, and 102 336 tested HIV-positive. Antiretroviral prophylaxis was dispensed to 81 384 mothers and 52 342 HIV-exposed infants. From available reporting, 1388 pregnant women were dispensed antiretroviral drugs for treatment and 9060 children received cotrimoxazole prophylaxis at 6 weeks. Conclusions:PMTCT services are integrated into maternal-child health services but adult and pediatric care and treatment programs often function independently, without coordination or linkages. Integrating care into maternal-child health services and linking mother's HIV status to child are necessary for HIV-infected mothers and HIV-exposed children to receive appropriate follow-up and treatment.
Filtrado de respuestas parciales en arquitecturas de recuperación de información distribuidas

El gran incremento del volumen de informacion disponible en linea desde hace unas decadas hace necesarias, cada vez mas, tecnicas de recuperacion de informacion con el objetivo de gestionar, recuperar y filtrar la informacion disponible por estos medios, Las lineas de investigacion actuales han descubierto la existencia de un cuello de botella en el canal de respuesta de las arquitecturas de recuperacion de informacion distribuida, debido, principalmente, al gran numero de respuestas parciales y su consiguiente influencia sobre las arquitecturas de comunicaciones y sobre los brokers de usuario. Por un lado, si disminuimos el numero de respuestas parciales generados por cada servidor de consulta, disminuimos la precision de la respuesta final; por el otro lado, si disenamos una arquitectura de comunicaciones que soporte el trafico generado obtenemos un claro cuello de botella al ordenar los resultados parciales en los brokers de usuario con el fin de seleccionar la respuesta final. La solucion que propone este trabajo consiste en una arquitectura filtrada de comunicaciones implementada mediante nodos programables, los cuales forman una subred que posee la capacidad de procesar de forma transparente el trafico que la atraviesa, con el objetivo de reducir la cardinalidad de las respuestas parciales. Asi pues la principal ventaja de usar nodos programables en vez de, por ejemplo, brokers es la transparencia; lo que permite construir infraestructuras de canales de respuesta altamente flexibles y facilmetne modificables en tiempo de ejecucion. Este trabajo analiza, disena, realiza, mide y discute un conjunto de algoritmos de filtrado de respuestas parciales (aquello tradicionalmente usados en ambitos de recuperacion de informacion y la familia de algoritmos BGFAST-Buffered and Grooved Filter with Adaptative and Scaled Threshold) ademas de una arquitectura de nodo programable (VAIN-Value Added Indepent Node), los cuales conjuntamente permiten r
Effect of β-mannanase on the digestibility of diets with different protein sources in dogs determined by different methodologies.

This experiment aimed at evaluating the effects of including the enzyme, β-mannanase, in dog (Canis lupus familiaris) diets based on either poultry (Gallus gallus domesticus) by-product meal (PBM) or soybean [Glycine max (L.) Merr. ] Meal (SBM). The second objective was to evaluate 3 methods for determining energy and nutrient digestibility values in diets fed to dogs: total fecal collection (TFC) and use of aia or crude fiber (CF) as a marker. Eight dogs were allotted to a replicated latin square (4 by 4) design. There were 2 diets based on PBM as the major protein source and 2 diets based on SBM as the major protein source. Within each protein source, 1 diet contained no β-mannanase and 1 diet contained 0.01% β-mannanase. Diets were fed for an adaptation period of 5 d followed by 5 d of TFC. Fecal score (1 = watery feces to 5 = dry, hard pellets), pH, DM, and fecal volume were determined. The apparent total tract digestibility (ATTD) of DM, OM, CP, ether extract (EE), N-free extract (NFE), and GE, and ME content were calculated using the methods of TFC, AIA, and CF. Data were analyzed as a 2 by 2 by 3 split-split-plot design (β-mannanase, protein source, and digestibility calculation procedure). There were interactions between protein source and β-mannanase (P < 0.05). Supplementation of β-mannanase increased ATTD of nutrients and energy and ME (+ 195.3 kcal/kg) and also reduced fecal production in the diet with SBM, but not in the diet that contained PBM. There was an interaction between digestibility calculation procedure and protein source (P < 0.05). The use of AIA overestimated ATTD of the diets containing PBM, but digestibility values estimated based on TFC and CF were not different. Dogs fed diets containing SBM produced more feces with greater moisture content and lower pH compared with dogs fed the PBM diet (P < 0.05). Addition of 0.01% β-mannanase increased (P < 0.05) the digestibility and ME content of the diets containing SBM, but did not improve (P > 0.05) fecal texture. Results indicated that values for ATTD of energy and nutrients in diets containing sbm are not different if they are calculated based on TFC, AIA, or CF, but use of AIA may result in an overestimation of values for ATTD of energy and nutrients in diets containing PBM.
The labelling approach to precise resource analysis on the source code , revisited ?

The labelling approach is a technique to lift cost models for non-functional properties of programs from the object code to the source. It allows to perform precise resource analysis of programs directly on the source code, reconciling functional and non functional analysis. The labelling approach is based on the preservation of the structure of the high level program in every intermediate language used by the compiler. In order to prove the cost model correct, the semantics of programs is described with a labelled transition system that makes the program structure observable. The original version of the labelling approach does not simply scale to function calls and it may not work properly with source instructions that have several predecessors. In the talk we will present an improved version that take cares of both limitations and that is more modular. Most of the results presented have being mechanised in the interactive theorem prover Matita.
A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells*

Previous studies have established constitutive activation of Stat3 protein as one of the molecular changes required for tumorigenesis. To develop novel therapeutics for tumors harboring constitutively active Stat3, compounds from the NCI 2000 diversity set were evaluated for inhibition of Stat3 DNA-binding activity in vitro. Of these, a novel platinum (IV) compound, IS3 295, interacted with Stat3 and inhibited its binding to specific DNA-response elements. Further analysis suggested noncompetitive-type kinetics for the inhibition of Stat3 binding to DNA. In human and mouse tumor cell lines with constitutively active Stat3, IS3 295 selectively attenuated Stat3 signaling, thereby inducing cell growth arrest at G0/G1 phase and apoptosis. Moreover, in transformed cells, IS3 295 repressed expression of cyclin D1 and bcl-xL, two of the known Stat3-regulated genes that are overexpressed in malignant cells, suggesting that IS3 295 mediates anti-tumor cell activity in part by blocking Stat3-mediated sub-version of cell growth and apoptotic signals. Together, our findings provide evidence for the inhibition of Stat3 activity and biological functions by IS3 295 through interaction with Stat3 protein. This study represents a significant advance in small molecule-based approaches to target Stat3 and suggests potential new applications for platinum (IV) complexes as modulators of the Stat3 pathway for cancer therapy.
Critical Dimension and Real-Time Temperature Control for Warped Wafers

Abstract In this paper, we present the experimental results on Critical Dimension (CD) control via real-time temperature control for warped wafers. As opposed to run-to-run control where information from the previous wafer or batch is used for control of the current wafer or batch, the approach here is real-time and make use of current information for control of the current wafer CD. In this paper we demonstrate that real-time control of the post-exposure bake temperature to give nonuniform temperature distribution across the warped wafer can reduce CD nonuniformity across the wafer.
All-trans Retinoic Acid Upregulates Reduced CD38 Transcription in Lymphoblastoid Cell Lines from Autism Spectrum Disorder

Deficits In social behavior In mice lacking the CD38 gene have been attributed to Impaired secretion of oxytocin. In humans, similar deficits in social behavior are associated with autistic spectrum disorder (ASD), for which genetic variants of CD38 have been pinpointed as provisional risk factors. We sought to explore, in an in vitro model, the feasibility of the theory that restoring the level of CD38 in ASD patients could be of potential clinical benefit. CD38 transcription is highly sensitive to several cytokines and vitamins. One of these, all-trans retinoic acid (ATRA), a known inducer of CD38, was added during cell culture and tested on a large sample of N = 120 lymphoblastoid cell (LBC) lines from ASD patients and their parents. Analysis of CD38 mRNA levels shows that ATRA has an upmodulatory potential on LBC derived from ASD patients as well as from their parents. The next crucial issue addressed in our study was the relationship between levels of CD38 expression and psychological parameters. The results obtained indicate a positive correlation between CD38 expression levels and patient scores on the Vineland Adaptive Behavior Scale. In addition, analysis of the role of genetic polymorphisms in the dynamics of the molecule revealed that the genotype of a single-nucleotide polymorphism (rs6449182; C>G variation) in the CpG island of intron 1, harboring the retinoic-acid response element, exerts differential roles in CD38 expression in ASD and in parental LBC. In conclusion, our results provide an empirical basis for the development of a pharmacological ASD treatment strategy based on retinoids.
Lysosomal response of a murine macrophage-like cell line persistently infected with Coxiella burnetii

The lysosomal response of a murine macrophage-like tumor cell line (J774) during persistent infection with Coxiella burnettii was examined. By using acid phosphatase as a lysosomal marker, it was shown that phagosome-lysosome fusion occurred in J774 cells persistently infected with C. burnetii. This observation was verified using thorium dioxide, an electron-dense compound that is sequestered in secondary lysosomes. The phagolysosomes contained viable replicating rickettsiae. Spectrofluorometric analysis indicated that the phagolysosomal pH of persistently infected cells was acidic. In attempts to correlate rickettsial survival with lysosome function, the activities of several lysosomal enzymes were assayed in both infected and uninfected cells. Activities of acid phosphatase and beta-acetylglucosaminidase were not significantly altered during infection. However, infected cells appeared to display slightly higher intracellular lysozyme, beta-glucuronidase, and beta-galactosidase activities.
Comparing transformer derating computed using the harmonic loss factor FHL and K-factor

The transformer losses will increase while it is supplying nonlinear load current. The derating measure for normal transformers is always taken to limit the temperature of windings or top-oil. In this paper, the formulations how to calculate the maximum permissible rms non-sinusoidal load current (Imax) using the harmonic loss factors FHL and K-factor were introduced. The difference of them was also reasoned and a case study illustrated the process of reasoning. The applications of these two factors were discussed too. Imax computed using FHL for normal transformer is more economical because Imax computed using K-factor is more conservative. Based on the actual monitoring data of harmonic component, K-factor is suitable for selecting right transformers in design and FHL for establishing transformers operation capability, therefore there is a harmonic loss margin when the transformers supply non-sinusoidal load.
Use of selective serotonin reuptake inhibitor medications for the treatment of child and adolescent mental illness

Comprehensive clinical management plans for treating depression or anxiety disorders in children and adolescents frequently include the use of selective serotonin reuptake inhibitor (SSRI) medications. This statement reviews empirical data regarding the effectiveness of specific SSRI medications, monitoring guidelines, and potential adverse effects of SSRI use including risk of suicidality. SSRI medications can be effective in treating child and adolescent depression and anxiety disorders. Untreated depressive illness may be more harmful than appropriate use of SSRI medication. Physicians should ensure careful elicitation and documentation of baseline depressive and anxious symptoms before initiating SSRI medication. Following medication initiation, patients should also be closely monitored for potential adverse effects, including suicidal ideation and behaviour.
Analysis of the Induced Stresses in Silicon During Thermcompression Cu-Cu Bonding of Cu-Through-Vias in 3D-SIC Architecture

A new approach to 3D stacking of chips is being developed at IMEC and is called 3D-stacked IC (3D-SIC). In this approach, interconnection between strata is achieved by thermo-compression bonding of Cu-vias to a Cu-landing pad. In this paper we use finite element methods to study the influence of the resultant induced stresses in silicon as a result of CTE mismatch between silicon and copper and that also caused by the applied thermo-compression bonding force. Bonding temperature is found to be the main cause of induced stresses during thermo-compression bonding. The induced stresses decreased with a decrease in the silicon thickness. The keep-away-zone of the transistors from the influence of stresses from the Cu-vias is found to be dependent on the diameter of the Cu-via and the doping concentration of the transistors.
The Impact of Cooperative Learning on Numerical Methods Course

Numerical Methods is a course that can be conducted using workshops and group discussion. This study has been implemented on undergraduate students of level two at the Faculty of Engineering, International Islamic University Malaysia. The Numerical Method course has been delivered to two Sections 1 and 2 with 44 and 22 students in each section, respectively. Systematic steps have been followed to apply the student centered learning approach in teaching Numerical Method course. Initially, the instructor has chosen the topic which was Euler’s Method to solve Ordinary Differential Equations (ODE) to be learned. The students were then divided into groups with five members in each group. Initial instructions have been given to the group members to prepare their subtopics before meeting members from other groups to discuss the subtopics in an expert group inside the classroom. For the time assigned for the classroom discussion, the setting of the classroom was rearranged to accommodate the student centered learning approach. Teacher strength was by monitoring the process of learning inside and outside the class. The students have been assessed during the migrating to the expert groups, recording of a video explanation outside the classroom and during the final examination. Euler’s Method to solve the ODE was set as part of Question 3(b) in the final exam. It is observed that none of the students from both sections obtained a zero grade in Q3(b), compared to Q3(a) and Q3(c). Also, for Section 1(44 students), 29 students obtained the full mark of 7/7, while only 10 obtained 7/7 for Q3(a) and no students obtained 6/6 for Q3(c). Finally, we can recommend that the Numerical Method course be moved toward more student-centered Learning classrooms where the students will be engaged in group discussion rather than having a teacher one man show. Keywords—Teacher centered learning, student centered learning, mathematic, numerical methods.