Miracle-dz/UniFAR-FTUs huggingface dataset:
Adecuación de soluciones de anonimato al problema de la privacidad de localización en WSN

Resumen—Los patrones de trafico caracteristicos de las redes inalambricas de sensores (WSNs) dan lugar al problema de la privacidad de localizacion. De manera similar, el trafico de los usuarios en Internet revela informacion sensible que puede ser protegida mediante sistemas de comunicacion anonima (ACS). Por ello, este trabajo analiza la posibilidad de adaptar las soluciones de anonimato tradicionales al problema particular de las redes de sensores. Hasta el momento estas soluciones habian sido rechazadas sin un analisis riguroso, argumentando simplemente que eran demasiado exigentes computacionalmente para los nodos sensores. Nuestros resultados demuestran que, en general, algunos ACS no cumplen los requisitos de privacidad necesarios en WSNs mientras que otros, que si los cumplen, se valen de una cantidad de recursos que superan la capacidad de los sensores.
A Categorical Approach for Recognizing Emotional Effects of Music

Recently, digital music libraries have been developed and can be plainly accessed. Latest research showed that current organization and retrieval of music tracks based on album information are inefficient. Moreover, they demonstrated that people use emotion tags for music tracks in order to search and retrieve them. In this paper, we discuss separability of a set of emotional labels, proposed in the categorical emotion expression, using Fisher's separation theorem. We determine a set of adjectives to tag music parts: happy, sad, relaxing, exciting, epic and thriller. Temporal, frequency and energy features have been extracted from the music parts. It could be seen that the maximum separability within the extracted features occurs between relaxing and epic music parts. Finally, we have trained a classifier using Support Vector Machines to automatically recognize and generate emotional labels for a music part. Accuracy for recognizing each label has been calculated; where the results show that epic music can be recognized more accurately (77.4%), comparing to the other types of music.
Regulation of DNA Replication During the Cell Cycle: Roles of Cdc7 Kinase and Coupling of Replication, Recombination, and Repair in Response to Replication Fork Arrest

DNA replication is central to cell growth, development, and generation of tissues and organs. Recent advances in understanding replication machinery have revealed striking conservation of components involved in the processes of DNA replication, from yeasts to human. The conservation extends even to bacteria for some basic components of replication apparatus. Eukaryotic DNA replication is regulated at various stages to ensure strict regulation during cell cycle. We have identified a novel mammalian kinase, Cdc7‐ASK (Activator of S phase Kinase), that plays a key role at the entry into S phase as a molecular switch for DNA replication. This kinase is specifically activated during S phase and triggers the firing of DNA replication by phosphorylating an essential DNA helicase component of the replication complex. Environmental stresses such as DNA damages or depletion of essential nutrients for DNA synthesis lead to unscheduled arrest of DNA replication forks. In bacteria, this leads to induction of altered modes of DNA replication, which may repair DNA damages, facilitate reassembly of replication machinery at the stalled replication fork, or do both. In eukaryotes, blocking replication forks usually induces both checkpoint responses, which prevent premature progression of cell cycle events before precise completion of the preceding cell cycle stage, and the recombinational repair system for the lesions. Possible common bases in recognition of stalled replication forks in bacteria and eukaryotes will be discussed. Furthermore, we will discuss the potential of replication and checkpoint proteins as targets of anticancer agents as well as possible novel technology for stem cell amplification through manipulation of DNA replication.
A 3.5-year follow-up of Internet-delivered cognitive behavior therapy for major depression

Background Internet-delivered cognitive behavior therapy (ICBT) for major depression has been tested in several trials, but only with follow-ups up to 1.5 years. Aim The aim of this study was to evaluate the outcome of ICBT 3.5 years after treatment completion. Methods A total of 88 people with major depression were randomized to either guided self-help or e-mail therapy in the original trial. One-third was initially on a waiting-list. Treatment was provided for eight weeks and in this report long-term follow-up data were collected. Also included were data from post-treatment and six-month follow-up. A total of 58% (51/88) completed the 3.5-year follow-up. Analyses were performed using a random effects repeated measures piecewise growth model to estimate trajectory shape over time and account for missing data. Results Results showed continued lowered scores on the Beck Depression Inventory (BDI). No differences were found between the treatment conditions. A large proportion of participants (55%) had sought and received additional treatments in the follow-up period. A majority (56.9%) of participants had a BDI score lower than 10 at the 3.5-year follow-up. Conclusions People with mild to moderate major depression may benefit from ICBT 3.5-years after treatment completion.
Calcul par éléments finis des pertes supplémentaires dans les motorisations performantes

Les pertes supplementaires en charge dans les machines electriques representent une contribution non-negligeable aux pertes totales. Elles constituent un point cle pour une evaluation exacte de l’efficacite energetique des moteurs. L’objectif de ce travail a donc ete d’investiguer les pertes supplementaires, de determiner et de quantifier leurs origines tout en effectuant une modelisation precise des machines electriques etudiees. Le modele de calcul des pertes supplementaires, developpe dans la these, est base sur l’essai normalise de bilan de puissances. L’utilisation de ce dernier necessite des modeles de calcul des pertes fer et des pertes par courants induits harmoniques. Le choix s’est porte sur des modeles de calcul des pertes en post-traitement d’un code par elements finis. Ces modeles ont ete testes dans un premier temps sur une machine synchrone a aimants permanents (MSAP) ou l’influence des harmoniques de decoupage a ete etudiee. Ensuite, les pertes supplementaires ont ete calculees pour un moteur de 500 kW et deux moteurs de 6 kW a barres droites et inclinees. Plusieurs etudes ont ete effectuees sur les origines des pertes supplementaires, comme les flux de fuite d’extremites, les flux de fuite zig-zag ainsi que les flux de fuite d’inclinaison, et leurs contributions ont ete quantifiees. La comparaison des resultats simules avec les mesures issues des essais effectues sur la MSAP et sur les deux maquettes montre une bonne concordance. Ces resultats demontrent la capacite des modeles proposes a estimer les pertes fer, les pertes par courants induits et les pertes supplementaires avec une bonne precision pour differents types de machines electriques et differents points de fonctionnements.
Kinetics of p24 antigenemia, IgM, IgG antibodies to p24 and p41 and Ig virus isolation in rabbits experimentally infected with HIV-1.

In rabbits experimentally infected with 1.10(5) u.i. /ml HIV, IgM antibodies were detected 10-15 days after infection, reaching peak value two weeks later and remaining stable for two weeks long. Then a the IgM serotiters progressively decreased and were negative at ten weeks. HIV p24 antigen was detected ten-fifteen days after infection, reaching peak value five-six weeks later. Antigenemia subsequently decreased and reached a second peak after nine weeks. In our experimental conditions, the antigenemia persisted throughout the observation period. The IgG antibody titer reached a maximum two weeks after infection; the time course showed a decrease after ten weeks, followed by progressively decreasing fluctuating course. After twenty four weeks of infection the serotiter values though lower were always positive. Three-four weeks after infection we detected IgG antibodies to the major core protein p24. Reactivity of IgG antibodies to gp41 was observed earlier than reactivity to p24; these antibodies were detected over six months after infection. Viruses indistinguishable from HIV were isolated from the peripheral blood mononuclear cells of infected rabbits 30, 60 and 180 days after infection. These data further confirm that the rabbit may serve as an economical and reproducible model for HIV infection in which vaccines and antiviral agents could be tested.
Efficacy of intracoronary nicardipine in the treatment of no‐reflow during percutaneous coronary intervention

Objectives: The goal of this study was to evaluate the safety and efficacy of nicardipine in reversing no‐reflow during percutaneous coronary intervention (PCI). Background: No‐reflow is a common complication of PCI in patients with acute coronary syndromes or venous bypass graft disease. Although nicardipine has an attractive pharmacological profile and has been used clinically to treat no‐reflow, there is a paucity of published data regarding its effectiveness in this setting. Methods: We conducted a retrospective analysis of 72 consecutive patients who received intracoronary nicardipine to reverse no‐reflow during coronary intervention. Qualitative TIMI flow grade and quantitative TIMI frame count methods were used to assess the efficacy of nicardipine. Results: A mean of 460 ± 360 mcg of intracoronary nicardipine was used. No‐reflow was successfully reversed with complete restoration of TIMI 3 flow in 71 of 72 patients (98.6%). TIMI flow grade improved from 1.65 ± 0.53 prior to nicardipine to 2.97 ± 0.24 after treatment (P < 0.001). TIMI frame count decreased from 57 ± 40 at the time of no‐reflow to 15 ± 12 after nicardipine administration (P < 0.001). Nicardipine therapy was well tolerated without adverse hemodynamic or chronotropic effects.Conclusions: In this largest series to date, intracoronary nicardipine was demonstrated to be a safe and highly effective pharmacological agent to reverse no‐reflow during PCI. © 2006 Wiley‐Liss, Inc.
End-to-end musical key estimation using a convolutional neural network

We present an end-to-end system for musical key estimation, based on a convolutional neural network. The proposed system not only out-performs existing key estimation methods proposed in the academic literature; it is also capable of learning a unified model for diverse musical genres that performs comparably to existing systems specialised for specific genres. Our experiments confirm that different genres do differ in their interpretation of tonality, and thus a system tuned e.g. for pop music performs subpar on pieces of electronic music. They also reveal that such cross-genre setups evoke specific types of error (predicting the relative or parallel minor). However, using the data-driven approach proposed in this paper, we can train models that deal with multiple musical styles adequately, and without major losses in accuracy.
Comparison of Sympathetic Nerve Activity in Normotensive and Hypertensive Subjects

A microneurographic technique was used to record multiunit sympathetic activity in skin and muscle nerves of 24 healthy subjects and 21 hypertensive subjects. In both groups, the sympathetic activity recorded during rest appeared in bursts following one of two highly different temporal patterns—one characteristic for muscle nerves and the other characteristic for skin nerves. Muscle nerve sympathetic activity probably consisting of vasoconstrictor impulses, occurred in bursts that followed the pulse rhythm and waxed and waned in inverse relation to spontaneous blood pressure fluctuations. Transient random elevations of blood pressure above a certain level caused total suppression of the sympathetic bursts. This inhibitory blood pressure level was higher in hypertensive subjects than it was in normotensive subjects, suggesting an elevated baroreflex working range in hypertension. No other important differences in muscle nerve sympathetic activity were noted between the two groups. Skin nerve sympathetic activity, probably consisting of both vasoconstrictor and sudomotor impulses, had a similar temporal pattern in normotensive and hypertensive subjects at rest: bursts of variable duration occurred randomly or were loosely related to the respiratory rhythm. In both groups of subjects, the strength of this activity increased in response to arousal stimuli, mental stress, and body cooling. These findings emphasize the necessity of having highly standardized experimental conditions in future studies aimed at a quantitative comparison of the absolute strength of sympathetic activity in normotensive and hypertensive subjects.
The Role of Task-Specific Training in Rehabilitation Therapies

Abstract Task-oriented therapy is important. It makes intuitive sense that the best way to relearn a given task is to train specifically for that task. In animals, functional reorganization is greater for tasks that are meaningful to the animal. Repetition alone, without usefulness or meaning in terms of function, is not enough to produce increased motor cortical representations. In humans, less intense but task-specific training regimens with the more affected limb can produce cortical reorganization and associated, meaningful functional improvements.
The effects of interferon on granulopoiesis in vitro

Colony formation by myeloid progenitor cells (CFU‐c) in agar was inhibited to the same extent by heterogeneous human leucocyte IFN (IFN‐Le) and 2 different cloned IFN‐a2 preparations, but ∼10 times less by cloned IFN‐α1; cluster formation remained unaffected by any of the interferons. An antiproliferative effect is suggested by both lower cell yield and DNA synthesis in IFN containing liquid cultures. Incubation of cells with IFN for 18 h prior to plating with colony stimulating factor (CSF) reduced colony formation, indicating an altered responsiveness of CFU‐c to CSF. In IFN treated cultures no consistent block of morphological differentiation occurred, but granulocyte alkaline phosphatase activity was reduced. Thus, IFN may play a modulatory role on functional markers. Our results indicate that the effects observed with heterogeneous preparations are due to IFN and not to impurities and that various differentiation parameters are unequally affected by IFN.
CEREBRAL PALSY AND NEWBORN CARE. III: ESTIMATED PREVALENCE RATES OF CEREBRAL PALSY UNDER DIFFERING RATES OF MORTALITY AND IMPAIRMENT OF LOW‐BIRTHWEIGHT INFANTS *

To maintain a stable over‐all prevalence of handicap, the rate of handicap among survivors must decline in parallel to the decline in mortality among live births. The 24 per cent decline in mortality among low‐birthweight infants in New York City between 1962 and 1976 requires a 35 to 39 per cent decline in the rate of neurological impairment among lowbirthweight survivors simply to avoid the production of an increased number of handicapped children in the population as a whole.
Two element MIMO antenna using Substrate Integrated Waveguide (SIW) horn

This paper presents a two element Multiple Input Multiple Output (MIMO) system based on H-plane horn antenna. Surface Integrated Waveguide technology has been used in order to increase the isolation between antenna elements. The antenna operates at 3.8 GHz and has a gain of 7.92 dB, which make it suitable for wireless communication application. This antenna takes advantage of both MIMO systems and SIW. MIMO system provides high data rate with diversity performance while SIW technology makes it compact and planar.
Cerebral ischemia, cell cycle elements and Cdk5

Stroke is a devastating disorder that significantly contributes to death, disability, and healthcare costs. New therapeutic strategies have been recently focusing on the development of neuroprotective agents that could halt the underlying mechanisms of neuronal death leading to brain damage. Accumulating evidence implicates proteins that are normally involved in the regulation of the cell cycle to neuronal death following ischemic insult, suggesting that these proteins could be suitable targets for stroke therapy. In this brief review, we present in vitro and in vivo arguments linking cell cycle molecules, i.e., cyclins, mitotic cyclin‐dependent kinases (Cdks), as well as non‐mitotic Cdk5, to ischemic neuronal death. We also report the evaluation of the potential of Cdk inhibitors as neuroprotective strategy for ischemic injury.
Generation and Therapeutic Efficacy of Highly Oligomer-Specific β-Amyloid Antibodies

Oligomers of the β-amyloid (Aβ) peptide have been indicated in early neuropathologic changes in Alzheimer's disease. Here, we present a synthetic Aβ20-42 oligomer (named globulomer) with a different conformation to monomeric and fibrillar Aβ peptide, enabling the generation of highly Aβ oligomer-specific monoclonal antibodies. The globulomer-derived antibodies specifically detect oligomeric but not monomeric or fibrillar Aβ in various Aβ preparations. The globulomer-specific antibody A-887755 was able to prevent Aβ oligomer binding and dynamin cleavage in primary hippocampal neurons and to reverse globulomer-induced reduced synaptic transmission. In amyloid precursor protein (APP) transgenic mice, vaccination with Aβ globulomer and treatment with A-887755 improved novel object recognition. The cognitive improvement is likely attributable to reversing a deficit in hippocampal synaptic spine density in APP transgenic mice as observed after treatment with A-887755. Our findings demonstrate that selective reduction of Aβ oligomers by immunotherapy is sufficient to normalize cognitive behavior and synaptic deficits in APP transgenic mice.
Inhaled nitric oxide for the prevention of bronchopulmonary dysplasia

This review provides the readers with background information on the state of the art and science of inhaled nitric oxide (iNO) as therapy for prevention or amelioration of bronchopulmonary dysplasia (BPD) in preterm infants. The goal is to review and critique relevant published information. A total of six clinical trials, all placebo-controlled, four out of six blinded, four out of six multi-centered with a predetermined outcome of reduction in death or BPD, have been reported in full text. These definitive studies have included a total of > 2100 preterm, mostly very preterm, infants. Their designs were informed by results of earlier non-definitive studies which cumulatively enrolled > 350 preterm patients. This very substantial experience provides a firm framework for asserting that iNO will be useful in this population of patients. The use of iNO can reduce the occurrence of BPD and possibly the severity of the disorder. Optimal time of initiation, dosing (both initial dose, duration of treatment and possibly the route of administration) and most importantly, optimal patient subset selection, are not determined. Any clear adverse neurological finding in iNO-treated infants will of course limit or halt the use of this promising therapy.
Positive and Negative Correlations Between Confidence and Accuracy for the Same Events in Recognition of Categorized Lists

Different researchers have reported positive, null, and negative relationships between confidence and accuracy in reports from memory. One possible reason for this paradox is the variety of materials used across experiments, but the two experiments reported in this article show that positive and negative confidence-accuracy correlations can be observed using a single procedure and the same materials. Subjects studied words from semantic categories and then took a recognition test while making confidence ratings. For previously studied items, positive correlations between confidence and accuracy were obtained using three different measures. Yet when confidence-accuracy correlations were assessed for unstudied items from studied categories, the correlations were zero or negative. The critical factors in determining when negative correlations will be found are the similarity of lures to presented items and the type of analysis used. These results indicate that one should be cautious about relying on confidence of recognition when rememberers must decide among highly similar events.
Phenotypic and ultrastructural characterization of a medullary thymocyte acute lymphoblastic leukemia with cellular procoagulant activity

The phenotypic and ultrastructural characterization of the blast cells from a T‐cell acute lymphoblastic leukemia (T‐ALL) that was associated with disseminated intravascular coagulation (DIC) is described. The bone marrow blasts were considered to represent neoplastic medullary thymocytes and were acid phosphatase (+), terminal deoxynucleotidyl transferase (‐), acid alpha‐naphthyl acetate esterase (‐), E‐rosette (+) at 4°C and 37°C, Fc‐ and C3‐receptor (‐), and cALLA‐, la‐, 9.6+, OKT3+, OKT4+, OKT6+/‐, OKT8+, OKT10+. On transmission electron miscroscopic study, the predominant cell was 6 μm in diameter and possessed an irregular nucleus, moderate‐sized nucleolus, marginated heterochromatin, abundant Golgi elements and granules, and prominent intermediate filaments. The cells were analyzed with normal and factor‐deficient human plasmas and contained significant amounts of tissue factor‐like procoagulant activity. This is the first report of a well‐characterized medullary thymocyte T‐ALL in which DIC was an accompanying feature, and the first demonstration of tissue factor‐like procoagulant activity in acute lymphoblastic leukemia. In view of thrombohemorrhagic phenomena observed in association with other medullary thymocyte leukemias, these findings suggest that tissue factor‐like procoagulant activity may be a characteristic of medullary thymocyte‐derived lymphoid leukemias.
Long-term Chelation Therapy in Thalassaemia Major: Effect on Liver Iron Concentration, Liver Histology, and Clinical Progress

A prospective trial of continuous chelation therapy in children with homozygous thalassaemia on a high transfusion regimen was started in April 1966. The effect of treatment on iron concentration in the liver and on hepatic histology was examined in 49 biopsy specimens obtained from nine chelator-treated patients and nine control patients between April 1966 and April 1973. Chelation therapy was associated with a significant reduction in liver iron concentration, and by the end of the trial the values for the two groups showed no overlap. A similar difference was seen in the amount of hepatic fibrosis, which showed little or no change in the chelator-treated patients but was progressive in the controls. No major clinical differences were seen, probably because both groups included several older children who were heavily loaded with iron at the start of the trial. Among the younger patients, however, puberty was delayed in four of five controls but in only one of four chelator-treated children. Prepubertal growth rate was significantly greater in the chelator-treated patients than in the controls.