Miracle-dz/UniFAR-FTUs huggingface dataset:
Systematic review of evidence for different treatment settings in anorexia nervosa.

AIM To compare outcomes in anorexia nervosa (AN) in different treatment settings: inpatient, partial hospitalization and outpatient. METHODS Completed and published in the English language, randomized controlled trials comparing treatment in two or more settings or comparing different lengths of inpatient stay, were identified by database searches using terms "anorexia nervosa" and "treatment" dated to July 2014. Trials were assessed for risk of bias and quality according to the Cochrane handbook by two authors (Madden S and Hay P) Data were extracted on trial quality, participant features and setting, main outcomes and attrition. RESULTS Five studies were identified, two comparing inpatient treatment to outpatient treatment, one study comparing different lengths of inpatient treatment, one comparing inpatient treatment to day patient treatment and one comparing day patient treatment with outpatient treatment. There was no difference in treatment outcomes between the different treatment settings and different lengths of inpatient treatment. Both outpatient treatment and day patient treatment were significantly cheaper than inpatient treatment. Brief inpatient treatment followed by evidence based outpatient care was also cheaper than prolonged inpatient care for weight normalization also followed by evidence based outpatient care. CONCLUSION There is preliminary support for AN treatment in less restrictive settings but more research is needed to identify the optimum treatment setting for anorexia nervosa.
Man's best friend: what can pet dogs teach us about non‐Hodgkin's lymphoma?

Animal models are essential for understanding lymphoma biology and testing new treatments prior to human studies. Spontaneously arising lymphomas in pet dogs represent an underutilized resource that could be used to complement current mouse lymphoma models, which do not adequately represent all aspects of the human disease. Canine lymphoma resembles human lymphoma in many important ways, including characteristic translocations and molecular abnormalities and similar therapeutic responses to chemotherapy, radiation, and newer targeted therapies (e.g. ibrutinib). Given the large number of pet dogs and high incidence of lymphoma, particularly in susceptible breeds, dogs represent a largely untapped resource for advancing the understanding and treatment of human lymphoma. This review highlights similarities in molecular biology, diagnosis, treatment, and outcomes between human and canine lymphoma. It also describes resources that are currently available to study canine lymphoma, advantages to be gained by exploiting the genetic breed structure in dogs, and current and future challenges and opportunities to take full advantage of this resource for lymphoma studies.
Enhancement by Thymectomy of Tumor Formation by Oncogenic Adenoviruses∗

Summary Adenoviral serotypes 1, 7, 8, 14, 21, and 24 were inoculated into thymectomized and nonthymectomized newborn Syrian hamsters because of their suspect oncogenicity in an initial screening program. Enhanced oncogenicity attributable to thymectomy at 1 week of age was observed when type 7 was inoculated subcutaneously. Tumor incidence increased from 4 to 17%. About 14% of the thymectomized hamsters inoculated with adenovirus 21 had tumors although this virus produced no tumors in intact animals of this series. All surviving animals remain under observation.
Temperature-Dependent Demography of Aulacaspis yasumatsui (Hemiptera: Diaspididae)

ABSTRACT Aulacaspis yasumatsui Takagi continues to threaten the extinction of the endemic and endangered Cycas taitungensis (Shen et al.) in Taiwan. Failure to understand its population demographic parameters in detail will continue to hinder the success of pest management practices. An in-depth knowledge of the development, survival, and fecundity of A. yasumatsui under different environmental conditions is necessary to understand its' population growth. The demography of A. yasumatsui was studied in the laboratory based on the age-stage, two-sex life table at 20, 23, 25, 28, and 31°C, 70% relative humidity, and a photoperiod of 16:8 (L:D) h. The intrinsic rate of increase (r) under these temperatures was 0.06, 0.07, 0.09, 0.10, and 0.08 d-1, respectively. The net reproductive rate (R0) was 46.27, 47.78, 69.50, 96.08, and 56.65 offsprings per individual and the mean generation time (T) was 65.60, 55.81, 47.82, 44.15, and 51.42 d, respectively. A. yasumatsui does well at warmer temperatures (25–28°C); however, its performance is disrupted at lower temperatures. This study provides insight on how to minimize growth and destruction of A. yasumatsui and conservation of Cy. taitungensis; new cycad reserves should be set up in cooler areas in Taiwan.
A Support for Organizational Learning Needs

Knowledge and competences capital of an organization are increasingly crucial. The organization survival depends mainly on its capacity to access new knowledge, to diffuse its competences quickly and to exploit and preserve its expertise fields efficiently and durably. Thus today, organizations are aware of the necessity to become learning organizations and to maximize organizational learning. Organizational learning process is composed by three sub-processes: a learning process, a knowledge management process and a social process. A web platform based on learning organization memory can answer to needs of all these sub-processes. This paper's aim, within the approach MEMORAe, is to model and design an organizational learning support. To that end, in order to take into account all the identified needs, it proposes to associate: educational engineering (e-learning), knowledge engineering (knowledge management and semantic web) and social engineering (web 2.0 technologies). This support is a web platform using ontologies, semantic annotations and Web 2.0 technologies in order to organize, share, and capitalize organizational competences, knowledge and resources. This article specifies concepts of learning organization, organizational learning and it underlines the existence of the three different sub-processes in this learning form: learning, knowledge management and social. It presents all these sub-processes and their needs. Then it presents its approach in describing learning organizational memory modelling and how it takes into account learning, knowledge management and social sub-processes. Finally, it describes the platform E-MEMORAe2.0 as tool to support organizational learning.
Viral tracer studies indicate contamination of marine waters by sewage disposal practices in key largo, Florida

Domestic wastewater disposal practices in the Florida Keys are primarily limited to on-site disposal systems such as septic tanks, injection wells, and illegal cesspits. Poorly treated sewage is thus released into the highly porous subsurface Key Largo limestone matrix. To investigate the fate and transport of sewage in the subsurface environment and the potential for contamination of marine surface waters, we employed bacteriophages as tracers in a domestic septic system and a simulated injection well in Key Largo, Florida. Transport of bacteriophage (Phi)HSIC-1 from the septic tank to adjacent surface canal waters and outstanding marine waters occurred in as little as 11 and 23 h, respectively. Transport of the Salmonella phage PRD1 from the simulated injection well to a canal adjacent to the injection site occurred in 11.2 h. Estimated rates of migration of viral tracers ranged from 0.57 to 24.2 m/h, over 500-fold greater than flow rates measured previously by subsurface flow meters in similar environments. These results suggest that current on-site disposal practices can lead to contamination of the subsurface and surface marine waters in the Keys.
Organization of ascending hypothalamic projections to the rostral forebrain with special reference to the innervation of cholinergic projection neurons

Axonal projections from hypothalamic nuclei to the basal forebrain, and their relation to cholinergic projection neurons in particular, were studied in the rat by using the anterograde tracer Phaseolus vulgaris‐leucoagglutinin (PHA‐L) in combination with choline acetyltransferase (ChAT) immunocytochemistry. Discrete iontophoretic PHA‐L injections were delivered to different portions of the caudal lateral hypothalamus, as well as to various medial hypothalamic areas, including the ventromedial, dorsomedial, and paraventricular nuclei, and anterior hypothalamic and medial preoptic areas. The simultaneous detection of PHA‐L‐labeled fibers/terminals and ChAT‐positive neurons was performed by using nickel‐enhanced diaminobenzidine (DAB) and nonenhanced DAB as chromogens. Selected cases were investigated at the electron microscopic level.
My dad’s a ‘barbie’ man and my mum’s the cooking girl

Academics from a variety of disciplines claim that gender has an influence on men’s and women’s food choices and portion sizes at mealtime and snack time. While these socially constructed norms present health-related implications for both men and women, it is arguable that men have a greater risk of problems associated with overweight as a consequence of gendered food choices and dietary practices. This article reports on qualitative research data attained from Australian boys in early childhood and middle primary school years. The data were thematically analysed using inductive analysis. The voices of boys provide the opportunity to understand how gendered food choices, among males, emerge in contemporary Western culture. Such research can also potentially play a role in developing strategies to assist boys in making healthy food selection, which will ultimately assist their food-related health literacy as they move towards adolescence and adulthood.
Clinical correlates of akathisia in acute psychiatric inpatients

&NA; This study identified acute and chronic akathisia in acute psychiatric inpatients receiving conventional antipsychotic medication, and evaluated the clinical characteristics, risk factors and clinical implications of the condition. Akathisia and other movement disorders were systematically assessed in patients consecutively admitted to an acute psychiatric ward over one year. Akathisia was diagnosed in 15 (21%) of 72 patients. Akathisia, developing as an acute condition in seven patients, generally presented with the subjective experience of dysphoria and unease without restless movements. This acute akathisia developed during the first few days of hospitalization and was associated with both a higher average dose of antipsychotic medication and a greater increase in dosage. In the remaining eight cases, akathisia was already present on admission, and thus classified as chronic. Those patients with chronic akathisia exhibited both subjective restlessness and the characteristic restless movements. Chronic akathisia was unrelated to antipsychotic dosage. The proportion of patients with akathisia who discontinued drug treatment was significantly higher than that for patients without the condition. Patients with acute akathisia tended to drop‐out of treatment and those with the chronic form tended to have treatment withdrawn by the prescribing clinician. One interpretation is that the subjective distress of acute akathisia may be particularly difficult for patients to tolerate and leads them to stop medication, while patients with more chronic akathisia may have become more accepting of the experience. Repetitive movements of the legs were observed more commonly in those with chronic rather than acute akathisia, and may represent a way of achieving some limited respite.
Genetics of muscle strength and power: Polygenic profile similarity limits skeletal muscle performance

Abstract Environmental and genetic factors influence muscle function, resulting in large variations in phenotype between individuals. Multiple genetic variants (polygenic in nature) are thought to influence exercise-related phenotypes, yet how the relevant polymorphisms combine to influence muscular strength in individuals and populations is unclear. In this analysis, 22 genetic polymorphisms were identified in the literature that have been associated with muscular strength and power phenotypes. Using typical genotype frequencies, the probability of any given individual possessing an “optimal” polygenic profile was calculated as 0.0003% for the world population. Future identification of additional polymorphisms associated with muscular strength phenotypes would most likely reduce that probability even further. To examine the genetic potential for muscular strength within a human population, a “total genotype score” was generated for each individual within a hypothetical population of one million. The population expressed high similarity in polygenic profile with no individual differing by more than seven genotypes from a typical profile. Therefore, skeletal muscle strength potential within humans appears to be limited by polygenic profile similarity. Future research should aim to replicate more genotype–phenotype associations for muscular strength, because only five common genetic polymorphisms identified to date have positive replicated findings.
Pilot testing of the ‘Haemo‐QoL’ quality of life questionnaire for haemophiliac children in six European countries

Summary. In a multinational working group, an instrument (Haemo‐QoL) to assess quality of life in children/adolescents with haemophilia and their parents has been developed. In co‐operation with haemophilia treatment centres in six European countries, approximately 10 children/adolescents with haemophilia per country and their parents were asked to participate in the pilot‐testing. Both self‐reported and parent‐reported questionnaires were provided for two age‐groups of children (4–16 years). Medical data was collected from physicians from patient files. Answers to open questions from participants (58 children and 57 parents) confirmed the content of 116 of the preliminary items. Cognitive debriefing revealed that the majority of the Haemo‐QoL was rated favourably, but 29 questions were recommended to be omitted and several items to be reformulated. Preliminary psychometric testing of the revised 77 item questionnaire in the same sample showed acceptable reliability and validity, which will be examined in a subsequent study with a larger patient sample.
Gene Expression Patterns of the Fibroblast Growth Factors and Their Receptors During Myogenesis of Rat Satellite Cells

Satellite cells are the myogenic precursors in postnatal muscle and are situated beneath the myofiber basement membrane. We previously showed that fibroblast growth factor 2 (FGF2, basic FGF) stimulates a greater number of satellite cells to enter the cell cycle but does not modify the overall schedule of a short proliferative phase and a rapid transition to the differentiated state as the satellite cells undergo myogenesis in isolated myofibers. In this study we investigated whether other members of the FGF family can maintain the proliferative state of the satellite cells in rat myofiber cultures. We show that FGF1, FGF4, and FGF6 (as well as hepatocyte growth factor, HGF) enhance satellite cell proliferation to a similar degree as that seen with FGF2, whereas FGF5 and FGF7 are ineffective. None of the growth factors prolongs the proliferative phase or delays the transition of the satellite cells to the differentiating, myogenin+ state. However, FGF6 retards the rapid exit of the cells from the myogenin+ state that routinely occurs in myofiber cultures. To determine which of the above growth factors might be involved in regulating satellite cells in vivo, we examined their mRNA expression patterns in cultured rat myofibers using RT-PCR. The expression of all growth factors, excluding FGF4, was confirmed. Only FGF6 was expressed at a higher level in the isolated myofibers and not in the connective tissue cells surrounding the myofibers or in satellite cells dissociated away from the muscle. By Western blot analysis, we also demonstrated the presence of FGF6 protein in the skeletal musle tissue. Our studies therefore suggest that the myofibers serve as the main source for the muscle FGF6 in vivo. We also used RT-PCR to analyze the expression patterns of the four tyrosine kinase FGF receptors (FGFR1-FGFR4) and of the HGF receptor (c-met) in the myofiber cultures. Depending on the time in culture, expression of all receptors was detected, with FGFR2 and FGFR3 expressed only at a low level. Only FGFR4 was expressed at a higher level in the myofibers but not the connective tissue cell cultures. FGFR4 was also expressed at a higher level in satellite cells compared to the nonmyogenic cells when the two cell populations were released from the muscle tissue and fractionated by Percoll density centrifugation. The unique localization patterns of FGF6 and FGFR4 may reflect specific roles for these members of the FGF signaling complex during myogenesis in adult skeletal muscle. (J Histochem Cytochem 48:1079–1096, 2000)
Small supernumerary marker chromosomes (sSMC) in humans

Small supernumerary marker chromosomes (sSMC), defined as additional centric chromosome fragments too small to be identified or characterized unambiguously by banding cytogenetics alone, are present in 0.043% of newborn children. Several attempts have been made to correlate certain sSMC with a specific clinical picture, resulting in the description of several syndromes such as the i(18p)-, der(22)-, i(12p)- (Pallister Killian syndrome) and inv dup(22)- (cat-eye) syndromes. However, most of the remaining sSMC including minute-, ring-, inverted-duplication- as well as complex-rearranged chromosomes, have not yet been correlated with clinical syndromes, mostly due to problems in their comprehensive characterization. Here we present an overview of sSMC, including the first attempt to address problems of nomenclature and their modes of formation, problems connected with mosaicism plus familial occurrence. The review also discusses the frequency of sSMC in prenatal, postnatal, and clinical cases, their chromosomal origin and their association with uniparental disomy. A short review of the up-to-date approaches available for sSMC characterization is included. Clinically relevant correlations concerning the presence of a specific sSMC and its phenotypic consequences should become available soon.
Maximum power point tracking techniques for solar water pumping systems

In this paper, we present a comparative study of single sensor-based maximum power point tracking (MPPT) techniques for solar photovoltaic (PV) water pumping systems. A conventional hill climbing algorithm is employed to find and track the MPP, using the information obtained from either a voltage sensor or a tachometer or a manometer. The results of experiment are included and explained to validate the proposed techniques.
LEO satellite communication networks - a routing approach

In the modern world of telecommunications, the concept of wireless global coverage is of the utmost importance. However, real global coverage can only be achieved by satellite systems. Until recently, the satellites were in geostationary orbit and their high altitude could not allow real-time communication such as cellular networks. The development of LEO satellite networks seems to overcome this limit. However, LEO satellite systems have specific characteristics that need to be taken into account. In the same manner, the TCP/IP standard was developed for terrestrial network. The need is then to come up with a solution that would permit the use of TCP/IP on LEO satellite networks without losing too many packets. The idea is to develop a routing algorithm that maximizes the RTT delays compared to the TCP timer granularity. For that matter, we use an FSA-based link assignment that simulates the satellite constellation as a fixed network for a predetermined time interval. In this configuration, the problem becomes a static routing problem where an algorithm can find the best solution. Copyright © 2003 John Wiley & Sons, Ltd.
Effects of Tissue Fixation and Processing on Proliferating Cell Nuclear Antigen (PCNA) Immunohistochemistry

Cell kinetics information is one of the most important indicator of treatment response and relapse in many types of human neoplasms. However, previous techniques for estimating proliferating rates have been complex, time-consuming, and not easily utilized with routine clinical materials. A monoclonal antibody (MoAb), PClO of Novacastra Lab. in UK, that recognizes a fixationand processing-resistant epitope of proliferating cell nuclear antigen (PCNA) has recently been employed to investigate the distribution of PCNA in tissue. This immunohistological method has particular advantages over other techniques with respect to the preservation of cellular and tissue architecture and also due to its relative simplicity of methodology and rapidity of results. Moreover, neither in vivo nor in vitro labeling is required and radioactivity can be avoided. Furthermore, the highly homologous nature of PCNA suggests that this protein plays an essential role in DNA synthesis in eukaryocytes (1). Therefore, the PCNA immunohistological method can be employed with not only animal but also plant tissues. PCNA immunoreactivity has been detected after fixation in a wide range of solutions including formalin and alcohol, but the duration of fixation can greatly alter the identifiability of PCNA immunoreactivity (2). More recently, cultured human cancer cells have been used to obtain excellent results following a protocol that employs 1 % paraformaldehyde in phosphate buffer pH 7.4 for 2 min at room temperature followed by methanol for 10 min at -20°C (3), and the usefulness of PClO has been evaluated as an S phase probe in flow cytometric analysis after various fixation procedures on human cell lines (4). In this study, the effects of various fixatives and fixation duration on PCNA immuno-
Hebbian induction of long-term potentiation of Aplysia sensorimotor synapses: partial requirement for activation of an NMDA-related receptor

Long-term potentiation (LTP) of Aplysia sensorimotor synapses in cell culture can be induced by pairing sensory neuron activity with depolarization of the motorneuron. This pairing-induced LTP is prevented by perfusion with D, L-2-amino-5-phosphononovalerate (APV), a selective antagonist for the N-methy-D-aspartate (NMDA) subclass of glutamate receptors. Repeated pairing of presynaptic activity with postsynaptic depolarization induces LTP comprising both APV-sensitive and APV-insensitive components. Infusing BAPTA, a selective Ca2+ chelator, into the postsynaptic motorneuron completely blocks pairing-induced LTP. These results demonstrate that Aplysia sensorimotor synapses are capable of hebbian LTP-similar to that exhibited by synapses in the mammalian hippocampus - and suggest a role for this type of synaptic plasticity in classical conditioning of the defensive withdrawal reflex of Aplysia.