Miracle-dz/UniFAR-FTUs huggingface dataset:
Aid policy in transition economies: impact on growth and migration

This thesis addresses aid in transition economies with regard to its effectiveness in enhancing growth (chapter 1 ), the allocation criteria (chapter 2 ), as well as its relationship with migration in the context of the policy coherence for development (chapter 3 ). This thesis contributes to the debate on aid conditionality with respect to the quality of macroeconomic policies, and of structural policy and institutional reforms. We identify a positive impact of aid on growth, but reject the conditionality issue. Aid does not necessarily perform better in a sound policy environment. The same goes for structural policy reforms and institutions. Our results indicate that a recipient's initial conditions play an important role in the process of macroeconomic adjustment and restructuring; furthermore, it appears that in countries with bad initial conditions aid is more effective in enhancing growth. However, the effect of initial conditions seems to decrease over time. This thesis adds to the literature on the criteria of aid allocation and the issue of donors' motivations for providing aid, while stressing, amongst the aid allocation criteria, the role of governance, considered as a signal of aid being put to good use, and, consequently, of improving aid allocation patterns. Finally, this thesis takes part to the debate about the necessity of a joint implementation of development policies vis-µa-vis developing countries, by studying aid in relation to migration. We show that aid and migration are substitutes above a threshold of about $7300 US per capita (PPP 2000 prices). For countries below this threshold, increases in income per capita, as a consequence of efficient aid policy, initially stimulate rather than dampen emigration; thus, for these countries, there is a trade-off between aid and migration policies. By identifying this threshold, we underline the importance of a coherent implementation of these policies, while considering their potential shortcomings.
Cerebral microbleeds in CADASIL

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy leading to recurrent cerebral infarcts and dementia. Intracerebral hemorrhage (ICH) has been described sporadically in patients with CADASIL, suggesting that the affected arteries in CADASIL are not bleed-prone. However, the presence of cerebral microbleeds, which often remain undetected on conventional MRI, has not been determined in CADASIL. Objective: To determine whether cerebral vessels in patients with CADASIL are prone to microbleeding. Methods: T2*-weighted gradient echo MRI, which is highly sensitive for visualizing microbleeds, was performed in patients with CADASIL and their family members (n = 63). Known risk factors for ICH were determined for all individuals. On an exploratory basis, the presence of cerebral microbleeds was correlated with demographic variables, vascular risk factors, disease progression, ischemic MR lesions, and genotype. Results: Cerebral microbleeds were present in 31% of symptomatic CADASIL mutation carriers, predominantly in the thalamus. Vascular risk factors such as hypertension did not account for the microbleeds in these patients. Factors associated with microbleeds were age (p = 0.008), Rankin disability score (p = 0.017), antiplatelet use (p = 0.025), number of lacunae on MRI (p = 0.009), and the Arg153Cys Notch3 mutation (p = 0.017). After correction for age, only the Arg153Cys mutation remained significantly associated with the presence of microbleeds. Conclusion: Patients with CADASIL have an age-related increased risk of intracerebral microbleeds. This implies that they may have an increased risk for ICH, which should be taken into account in CADASIL diagnosis and patient management.
Effects of recombinant activated factor VII on coagulation measured by thromboelastography in liver transplantation

Besides the conventional laboratory tests, thromboelastography (TEG) is used to monitor hemostasis during liver transplantation. A previous pilot study suggested a beneficial effect of recombinant activated factor VII (rFVIIa) on transfusion requirements in liver transplantation. In the present study, we assess the effects of rFVIIa on coagulation variables and TEG. In six study patients, the prothrombin time (PT), the activated partial thromboplastin time (aPTT) and TEG variables [reaction time (r), kinetic time (k), or clot formation time, α angle (α), and maximal amplitude (MA)] were recorded before and after the administration of a bolus of 80 μg/kg rFVIIa. These patients were compared with six controls who did not receive rFVIIa. In contrast with the control group, a significant shortening of PT (P = 0.028) and aPTT (P = 0.028), r (P = 0.046) and k (P = 0.043) values, and a significant incline of the α angle (P = 0.028) were noticed after injection of rFVIIa, whereas MA increased not significantly (P = 0.075). rFVIIa rapidly improved coagulation variables in liver transplant patients including PT and aPTT. Of the TEG variables, r, k and α angle significantly improved, and MA showed a trend to increase. These data suggest that rFVIIa not only influences the speed of clot formation, but also the physical properties of the clot, which cannot be detected by routine coagulation tests.
Housing bubbles assessment 2005-2010: Experiences in Klang Valley, Malaysia

During the period 2005-2010, Klang Valley had experienced a dramatic run-up in housing prices. However, once the housing price deviates too much from its fundamental value, it may give rise to problems and even generates subprime crisis. This paper will discuss whether there are housing bubbles in selected Klang Valley areas based on different district by incorporating the examination of macro-economic indicators with micro measures, using a comprehensive set of indicators to test the bubbles. The analysis on housing bubble merely lingered around two specific residential property, they are double story type and condominium type. The study is done on five carefully selected district in Klang Valley using the Rational Expectation Model and FamaFrench Three Factor Model. Generally, the study focuses on the existence of housing bubble that stemmed directly from the housing price and the expected housing price in the study area. The study exhibited that the expected price creates very high positive bond towards the market price thus making it the main contributor to the increasing prices of sale and rental within the property market. The general finding of this paper strongly suggested that the existence of housing bubbles in Klang Valley residential property market is getting bigger and stronger.
Barriers to minority participation in breast carcinoma prevention trials

Breast carcinoma prevention trials must recruit large cohorts of women who have an above‐average risk of developing breast carcinoma. Recruitment for the Study of Tamoxifen and Raloxifene (STAR) trial required volunteers to complete a risk assessment questionnaire form (RAF). Women whose estimated risk of developing breast carcinoma in the next 5 years was ≥ 1.67% based on the Gail model were invited to participate in STAR. Less than 4% of participants in the previously conducted P1 (tamoxifen vs. placebo) trial were minority women. We, therefore, studied barriers to minority participation in STAR among black, white, and Hispanic women who completed an RAF.
Blood-based protein biomarkers for diagnosis of Alzheimer disease.

OBJECTIVE To identify plasma biomarkers for the diagnosis of Alzheimer disease (AD). DESIGN Baseline plasma screening of 151 multiplexed analytes combined with targeted biomarker and clinical pathology data. SETTING General community-based, prospective, longitudinal study of aging. PARTICIPANTS A total of 754 healthy individuals serving as controls and 207 participants with AD from the Australian Imaging Biomarker and Lifestyle study (AIBL) cohort with identified biomarkers that were validated in 58 healthy controls and 112 individuals with AD from the Alzheimer Disease Neuroimaging Initiative (ADNI) cohort. RESULTS A biomarker panel was identified that included markers significantly increased (cortisol, pancreatic polypeptide, insulinlike growth factor binding protein 2, β(2) microglobulin, vascular cell adhesion molecule 1, carcinoembryonic antigen, matrix metalloprotein 2, CD40, macrophage inflammatory protein 1α, superoxide dismutase, and homocysteine) and decreased (apolipoprotein E, epidermal growth factor receptor, hemoglobin, calcium, zinc, interleukin 17, and albumin) in AD. Cross-validated accuracy measures from the AIBL cohort reached a mean (SD) of 85% (3.0%) for sensitivity and specificity and 93% (3.0) for the area under the receiver operating characteristic curve. A second validation using the ADNI cohort attained accuracy measures of 80% (3.0%) for sensitivity and specificity and 85% (3.0) for area under the receiver operating characteristic curve. CONCLUSIONS This study identified a panel of plasma biomarkers that distinguish individuals with AD from cognitively healthy control subjects with high sensitivity and specificity. Cross-validation within the AIBL cohort and further validation within the ADNI cohort provides strong evidence that the identified biomarkers are important for AD diagnosis.
An Experimental Investigation of Product Competition and Marketing in Social Networks

We conduct computational experiment using Facebook data to evaluate competing firms’ initial market seeding and subsequent targeted marketing strategies that influence consumers’ new product adoption decisions. We find that firms generally overspend their advertising budget in the market seeding phase. In the subsequent market advertising phase, a coupon strategy (equivalent to price discount) generally yields higher market share than the strategy of distributing free product samples. The effect is more significant when both price and product quality are low. We offer managerial insights into firms’ effective competition strategies for new product introduction in the presence of consumers’ word of mouth effects in social networks.
Reconstitution of O-Specific Lipopolysaccharide Expression in Burkholderia cenocepacia Strain J2315, Which Is Associated with Transmissible Infections in Patients with Cystic Fibrosis

ABSTRACT Burkholderia cenocepacia is an opportunistic bacterium that infects patients with cystic fibrosis. B. cenocepacia strains J2315, K56-2, C5424, and BC7 belong to the ET12 epidemic clone, which is transmissible among patients. We have previously shown that transposon mutants with insertions within the O antigen cluster of strain K56-2 are attenuated for survival in a rat model of lung infection. From the genomic DNA sequence of the O antigen-deficient strain J2315, we have identified an O antigen lipopolysaccharide (LPS) biosynthesis gene cluster that has an IS402 interrupting a predicted glycosyltransferase gene. A comparison with the other clonal isolates revealed that only strain K56-2, which produced O antigen and displayed serum resistance, lacked the insertion element inserted within the putative glycosyltransferase gene. We cloned the uninterrupted gene and additional flanking sequences from K56-2 and conjugated this plasmid into strains J2315, C5424, and BC7. All the exconjugants recovered the ability to form LPS O antigen. We also determined that the structure of the strain K56-2 O antigen repeat, which was absent from the LPS of strain J2315, consisted of a trisaccharide unit made of rhamnose and two N-acetylgalactosamine residues. The complexity of the gene organization of the K56-2 O antigen cluster was also investigated by reverse transcription-PCR, revealing several transcriptional units, one of which also contains genes involved in lipid A-core oligosaccharide biosynthesis.
TLR3 deficiency in herpes simplex encephalitis

Objective: To determine the proportion of children with herpes simplex encephalitis (HSE) displaying TLR3 deficiency, the extent of TLR3 allelic heterogeneity, and the specific clinical features of TLR3 deficiency. Methods: We determined the sequence of all exons of TLR3 in 110 of the 120 patients with HSE enrolled in our study who do not carry any of the previously described HSE-predisposing mutations of TLR3 pathway genes (TLR3, UNC93B1, TRIF, TRAF3, and TBK1). All the new mutant TLR3 alleles detected were characterized experimentally in-depth to establish the causal relationship between the genotype and phenotype. Results: In addition to the 3 previously reported TLR3-deficient patients from the same cohort, 6 other children or young adults with HSE carry 1 of 5 unique or extremely rare (minor allele frequency <0.001) missense TLR3 alleles. Two alleles (M374T, D592N) heterozygous in 3 patients are not deleterious in vitro. The other 3 are deleterious via different mechanisms: G743D+R811I and L360P heterozygous in 2 patients are loss-of-function due to low levels of expression and lack of cleavage, respectively, and R867Q homozygous in 1 patient is hypomorphic. The 3 patients' fibroblasts display impaired TLR3 responses and enhanced herpes simplex virus 1 susceptibility. Overall, TLR3 deficiency is therefore found in 6 (5%) of the 120 patients studied. There is high allelic heterogeneity, with 3 forms of autosomal dominant partial defect by negative dominance or haploinsufficiency, and 2 forms of autosomal recessive defect with complete or partial deficiency. Finally, 4 (66%) of the 6 TLR3-deficient patients had at least 1 late relapse of HSE, whereas relapse occurred in only 12 (10%) of the total cohort of 120 patients. Conclusions: Childhood-onset HSE is due to TLR3 deficiency in a traceable fraction of patients, in particular the ones with HSE recurrence. Mutations in TLR3 and TLR3 pathway genes should be searched and experimentally studied in children with HSE, and patients with proven TLR3 deficiency should be followed carefully.
Communication-aware computing for edge processing

We consider a mobile edge computing problem, in which mobile users offload their computation tasks to computing nodes (e.g., base stations) at the network edge. The edge nodes compute the requested functions and communicate the computed results to the users via wireless links. For this problem, we propose a Universal Coded Edge Computing (UCEC) scheme for linear functions to simultaneously minimize the load of computation at the edge nodes, and maximize the physical-layer communication efficiency towards the mobile users. In the proposed UCEC scheme, edge nodes create coded inputs of the users, from which they compute coded output results. Then, the edge nodes utilize the computed coded results to create communication messages that zero-force all the interference signals over the air at each user. Specifically, the proposed scheme is universal since the coded computations performed at the edge nodes are oblivious of the channel states during the communication process from the edge nodes to the users.
The Mos pathway regulates cytoplasmic polyadenylation in Xenopus oocytes

Cytoplasmic polyadenylation controls the translation of several maternal mRNAs during Xenopus oocyte maturation and requires two sequences in the 3' untranslated region (UTR), the U-rich cytoplasmic polyadenylation element (CPE), and the hexanucleotide AAUAAA. c-mos mRNA is polyadenylated and translated soon after the induction of maturation, and this protein kinase is necessary for a kinase cascade culminating in cdc2 kinase (MPF) activation. Other mRNAs are polyadenylated later, around the time of cdc2 kinase activation. To determine whether there is a hierarchy in the cytoplasmic polyadenylation of maternal mRNAs, we ablated c-mos mRNA with an antisense oligonucleotide. This prevented histone B4 and cyclin A1 and B1 mRNA polyadenylation, indicating that the polyadenylation of these mRNAs is Mos dependent. To investigate a possible role of cdc2 kinase in this process, cyclin B was injected into oocytes lacking c-mos mRNA. cdc2 kinase was activated, but mitogen-activated protein kinase was not. However, polyadenylation of cyclin B1 and histone B4 mRNA was still observed. This demonstrates that cdc2 kinase can induce cytoplasmic polyadenylation in the absence of Mos. Our data further indicate that although phosphorylation of the CPE binding protein may be involved in the induction of Mos-dependent polyadenylation, it is not required for Mos-independent polyadenylation. We characterized the elements conferring Mos dependence (Mos response elements) in the histone B4 and cyclin B1 mRNAs by mutational analysis. For histone B4 mRNA, the Mos response elements were in the coding region or 5' UTR. For cyclin B1 mRNA, the main Mos response element was a CPE that overlaps with the AAUAAA hexanucleotide. This indicates that the position of the CPE can have a profound influence on the timing of cytoplasmic polyadenylation.
Double blind dose-response study of zidovudine in AIDS and advanced HIV infection. Nordic Medical Research Councils' HIV Therapy Group.

OBJECTIVE--To compare the efficacy and side effects of 400 mg, 800 mg, and 1200 mg zidovudine daily in patients with AIDS or advanced HIV infection. DESIGN--Randomised, double blind, parallel group multicentre study. SETTING--Hospital departments of infectious diseases and dermatology in Denmark, Sweden, Norway, Finland, and Iceland. SUBJECTS--474 patients: 126 (27%) with AIDS; 248 (52%) with HIV related symptoms; 100 (21%) with low CD4+ cell counts. INTERVENTIONS--Zidovudine 400 mg (160 patients), 800 mg (158), or 1200 mg (156) daily. All patients received one capsule from each of three bottles four times daily. MAIN OUTCOME MEASURES--Survival; incidence of new HIV related events; CD4+ cell count; quality of life; incidence of haematological side effects. RESULTS--460 (97%) of the 474 patients had not received zidovudine previously. The median follow up period was 19 months, during which the death rates in the three treatment groups were 23% (36/160 patients), 23% (36/158), and 19% (30/156) respectively (p = 0.49; log rank test). One year after the trial was terminated the death rates were 38% (61/160), 41% (64/158), and 44% (68/156) respectively (p = 0.54). There was no significant difference between the groups in time to a new AIDS defining event or death, average number of events per patient, decline in CD4+ cell counts, wellbeing (visual analogue scale), or Karnofsky score. Zidovudine was withdrawn in 132 (28%) patients, mainly because of side effects (71 cases; 15%). The incidences of anaemia and leucopenia, time to first dose reduction, and numbers of patients withdrawn were all dose related. CONCLUSION--Zidovudine should be limited to 400-600 mg daily in patients with AIDS or advanced HIV infection.
Matching Level And Investors’ Heterogeneous Beliefs

This study investigated the relation between matching level and investors’ heterogeneous beliefs using listed firm (KOSPI) data in Korea. This study is based on prior research that reported that the higher the matching level, the less the noise included in accounting earnings and the higher the earnings quality. Karpoff (1986), Bamber (1987), Ajinkya, Atiase, & Gift (1991) and Dormeier (2011) explain that if there are different interpretations among investors regarding intrinsic value of a company, as a result, the trading volume can represent investors’ heterogeneous beliefs. Whereas the previous studies on matching level analyzed what kind of impact matching level improvement has on earnings quality, accumulated market adjusted return, foreign ownership, future earnings response coefficient (FERC) and bond credit rating. However, these studies have problems in measuring the matching level. So this study suggested additional proxy on matching level in addition to the proxy used in previous studies. Specifically, we analyzed the matching level model of Paek’s (2011b) by using the Prais-Winsten estimation method and then used the calculated explanatory power (Adj.R 2 ) as a proxy for the additional matching level. To empirically analyze hypothesis of this study, we used firm-year observation from 4,094 firms listed on Korean Stock Exchange over the period from 2003 to 2011. We found that matching level regression coefficient consistently showed significantly negative values for each measurement. Moreover, we analyzed additionally by measuring the calculated regression coefficient (β 2 ) of current expenses as matching level response coefficient after analyzing Dichev and Tang’s (2008) matching level measuring model by Prais-Winsten estimation method. It showed that regression coefficient of the current expenses and trading volume have negative correlation. This is consistent with this study, and it can be analyzed that as matching level improves, investors’ heterogeneous beliefs decrease. According to microeconomics theory of Mas-Colell, Whinston, and Green (1995), trading volume is explained to affect price changes. However, accounting and related studies analyze the information effect by using price change only. In this sense, this study is meaningful in that it conducted an analysis on the information effect of matching level through trading volume. In addition, this study contributes to understand the microscopic structure of the capital market.
Antibodies to conserved epitopes of the HIV-1 envelope in sera from long-term non-progressors: prevalence and association with neutralizing activity

Objective:Previous studies have shown that broadly neutralizing antibodies (NAb) are more frequent in long-term non-progressors (LTNP) than in other HIV-1 infected patients, but nothing is known about the envelope regions targeted by these broadly NAb. We investigated whether the breadth of neutralizing activity of sera was associated with the presence of specific antibodies (2F5- and/or 4E10-like, b12-like or 2G12-like antibodies) directed against conserved epitopes known to be involved in broad neutralization. Methods:We assessed the ability of sera from 67 LTNP of the French ANRS cohort (ANRS CO15) to neutralize four heterologous primary isolates of four various clades. Competitive and non-competitive ELISA were developed for the specific comparison of levels of antibodies against these specific epitopes in neutralizing and non-neutralizing sera from LTNP. Results:We found that higher 2G12-like antibody levels were significantly associated with the broadest neutralizing activity in sera from LTNP. Levels of 2G12-like antibodies were higher in the sera that neutralized the four isolates than in the others, with a median of 5.7 μg/ml [interquartile range (IQR), 2.7–9.3 μg/ml] versus 2.3 μg/ml (IQR, 1.1–3.9 μg/ml) (Mann–Whitney test, P = 0.03). Levels of antibodies against the other targeted envelope epitopes did not differ significantly between broadly and non-broadly neutralizing sera. Conclusion:These results suggest that the antigenicity of the ‘silent face’ of gp120 that exposes the 2G12 epitope should be analysed in more detail, to find ways to induce broadly neutralizing antibodies.