Miracle-dz/UniFAR-FTUs huggingface dataset:
Object-based estimation of dense motion fields

Motion estimation belongs to key techniques in image sequence processing. Segmentation of the motion fields such that, ideally, each independently moving object uniquely corresponds to one region, is one of the essential elements in object-based image processing. This paper is concerned with unsupervised simultaneous estimation of dense motion fields and their segmentations. It is based on a stochastic model relating image intensities to motion information. Based on the analysis of natural images, a region-based model of motion-compensated prediction error is proposed. In each region the error is modeled by a white stationary generalized Gaussian random process. The motion field and its segmentation are themselves modeled by a compound Gibbs/Markov random field accounting for statistical bindings in spatial direction and along the direction of motion trajectories. The a posteriori distribution of the motion field for a given image sequence is formulated as an objective function, such that its maximization results in the MAP estimate. A deterministic multiscale relaxation technique with regular structure is employed for optimization of the objective function. Simulation results are in a good agreement with human perception for both the motion fields and their segmentations.
The Matrix Reloaded: How Sensing the Extracellular Matrix Synchronizes Bacterial Communities

ABSTRACT In response to chemical communication, bacterial cells often organize themselves into complex multicellular communities that carry out specialized tasks. These communities are frequently referred to as biofilms, which involve the collective behavior of different cell types. Like cells of multicellular eukaryotes, the biofilm cells are surrounded by self-produced polymers that constitute the extracellular matrix (ECM), which binds them to each other and to the surface. In multicellular eukaryotes, it has been evident for decades that cell-ECM interactions control multiple cellular processes during development. While cells both in biofilms and in multicellular eukaryotes are surrounded by ECM and activate various genetic programs, until recently it has been unclear whether cell-ECM interactions are recruited in bacterial communicative behaviors. In this review, we describe the examples reported thus far for ECM involvement in control of cell behavior throughout the different stages of biofilm formation. The studies presented in this review have provided a newly emerging perspective of the bacterial ECM as an active player in regulation of biofilm development.
Tribute to Dr Jacques Rogge: muscle activity and fatigue during hiking in Olympic dinghy sailing

Abstract ‘A tribute to Dr J. Rogge’ aims to systematically review muscle activity and muscle fatigue during sustained submaximal quasi-isometric knee extension exercise (hiking) related to Olympic dinghy sailing as a tribute to Dr Rogge’s merits in the world of sports. Dr Jacques Rogge is not only the former President of the International Olympic Committee, he was also an orthopaedic surgeon and a keen sailor, competing at three Olympic Games. In 1972, in fulfilment of the requirements for the degree of Master in Sports Medicine, he was the first who studied a sailors’ muscle activity by means of invasive needle electromyography (EMG) during a specific sailing technique (hiking) on a self-constructed sailing ergometer. Hiking is a bilateral and multi-joint submaximal quasi-isometric movement which dinghy sailors use to optimize boat speed and to prevent the boat from capsizing. Large stresses are generated in the anterior muscles that cross the knee and hip joint, mainly employing the quadriceps at an intensity of 30–40% maximal voluntary contraction (MVC), sometimes exceeding 100% MVC. Better sailing level is partially determined by a lower rate of neuromuscular fatigue during hiking and for ≈60% predicted by a higher maximal isometric quadriceps strength. Although useful in exercise testing, prediction of hiking endurance capacity based on the changes in surface EMG in thigh and trunk muscles during a hiking maintenance task is not reliable. This could probably be explained by the varying exercise intensity and joint angles, and the great number of muscles and joints involved in hiking. Highlights Dr Jacques Rogge, former president of the International Olympic Committee and Olympic Finn sailor, was the first to study muscle activity during sailing using invasive needle EMG to obtain his Master degree in Sports Medicine at the Ghent University. Hiking is a critical bilateral and multi-joint movement during dinghy racing, accounting for >60% of the total upwind leg time. Hiking generates large stresses in the anterior muscles that cross the knee and hip joint. Hiking is considered as a quasi-isometric bilateral knee extension exercise. Muscle activity measurements during sailing, recorded by means of EMG, show a mean contraction intensity of 30-40% maximal voluntary contraction with peaks exceeding 100%. Hiking performance is strongly related to the development of neuromuscular fatigue in the quadriceps muscle. Since maximal strength is an important determinant of neuromuscular fatigue during hiking, combined strength and endurance training should be incorporated in the training program of dinghy sailors.
The Effect of Work Activity in Pregnancy on the Risk of Severe Preeclampsia

Summary: The aim of this study was to evaluate the impact of type of employment and level of physical activity at work on the risk of severe preeclampsia. For this purpose, we carried out a case control study of 160 nulliparous pregnant women with severe preeclampsia and 320 normotensive nulliparous controls who received prenatal care from members of one medical staff. The type of employment and the level of physical activity sustained at work were ascertained at birth through an interview based on a standard questionnaire. The degree of physical activity at work was assessed by a 4‐level activity score based on type of work, physical intensity, posture at work, and weekly working hours. In logistic regression analysis, after adjustment for potential confounders (maternal age, time of stopping work, prepregnancy body mass index, social status of the partner, history of previous abortion, and prepregnancy smoking status), clerical workers had a significantly lower risk of severe preeclampsia than women who were unemployed at the beginning of pregnancy (OR 0.53, 95% CI 0.30, 0.96). In multivariate analysis, there was a significant linear trend relating the degree of physical activity at work, to the risk of preeclampsia (likelihood chi‐square = 9.38, 3 df, p = 0.002). We then restricted the analysis to women who had ever worked in pregnancy (n = 339) also adjusting for confounders, and found that clerical workers were still at significantly lower risk of severe preeclampsia dian women not formally employed (OR 0.2,95% CI 0.08,0.49). In addition, moderate/high physical activity at work was associated with a 2‐fold increase in the risk of severe preeclampsia compared to mild activity (OR 2.08, 95% CI 1.11,3.88). We conclude that moderate to high physical activity at work seems to increase the risk of severe preeclampsia.
Performance sensor for tolerance and predictive detection of delay-faults

This paper presents the Scout Flip-Flop, a new performance Sensor for toleranCe and predictive detectiOn of delay-faUlTs in synchronous digital circuits. The sensor is based on a new master-slave Flip-Flop (FF), the Scout FF, with built-in functionality to locally (inside the FF) create two distinct guard-band windows: (1) a tolerance window, to increase tolerance to late transitions, making the Scout's master latch transparent during an additional predefined period after the clock trigger; and (2) a detection window, which starts before the clock edge trigger and persists during the tolerance window, to inform that performance and circuit functionality is at risk. When a PVTA (Process, power-supply Voltage, Temperature and Aging) variation occurs, circuit performance is affected and a delay-fault may occur. Hence, the existence of a tolerance window, introduces an extra time-slack by borrowing time from subsequent clock cycles. Moreover, as the predictive-error detection window starts prior to the clock edge trigger, it provides an additional safety margin and may be used to trigger corrective actions before real error occurrence, such as clock frequency reduction. Both tolerance and detection windows are defined by design and are sensitive to performance errors, increasing its size in worst PVTA conditions. Extensive SPICE simulations allowed characterizing the new flip-flop and simulation results are presented for 65nm CMOS technology, using Berkeley Predictive Technology Models (PTM), showing Scout's effectiveness on tolerance and predictive error detection.
Adenosine Diphosphate-Induced Platelets Aggregability in Polysomnographically Verified Obstructive Sleep Apnea

Obstructive sleep apnea syndrome (OSAS) is a risk factor for arterial thrombosis and cardiovascular morbidity. Activated platelets play key roles in the development of atherothrombosis, thus may be involved in these complications of OSAS. Herein, we evaluated the relationship between severity of OSAS and the degree of platelet aggregates as a marker of activated platelets in 64 patients with OSAS. Platelet aggregations were determined by means of optical aggregometry, using adenosine diphosphate (ADP) as an agonist. Compared with the control group, ADP-induced platelet aggregability was increased in patients with total OSAS, severe OSAS, and in mild to moderate OSAS. Moreover, ADP-induced platelet aggregation was correlated with the Epworth sleepiness scale (ESS) in patients with severe OSAS. Obstructive sleep apnea syndrome is associated with enhanced platelets aggregations, which may predispose the cardiovascular sequels. The ESS may be important in predicting platelet activation and thus atherothrombotic complications in those with OSAS.
Urban Emergency Management: Planning and Response for the 21st Century

Urban Emergency Management: Planning and Response for the 21st Century takes the concepts and practices of emergency management and places them in the context of the complex challenges faced by the contemporary city. Cities provide unique challenges to emergency managers. The concentrated population and often dense layering of infrastructure can be particularly susceptible to disasters? both natural and human-caused. The book provides guidance across all phases of emergency management, including prevention and all-hazards approaches.Presents an all-hazards and all-phases approach to emergency management, including natural hazards and human-caused disastersCovers the human capital and political and leadership qualities needed by urban emergency managersTargets the needs of emergency management in urban settings
Late coronary occlusion after intracoronary brachytherapy.

BACKGROUND Intracoronary brachytherapy appears to be a promising technology to prevent restenosis. Presently, limited data are available regarding the late safety of this therapeutic modality. The aim of the study was to determine the incidence of late (>1 month) thrombosis after PTCA and radiotherapy. METHODS AND RESULTS From April 1997 to March 1999, we successfully treated 108 patients with PTCA followed by intracoronary beta-radiation. Ninety-one patients have completed at least 2 months of clinical follow-up. Of these patients, 6.6% (6 patients) presented with sudden thrombotic events confirmed by angiography 2 to 15 months after intervention (2 balloon angioplasty and 4 stent). Some factors (overlapping stents, unhealed dissection) may have triggered the thrombosis process, but the timing of the event is extremely unusual. Therefore, the effect of radiation on delaying the healing process and maintaining a thrombogenic coronary surface is proposed as the most plausible mechanism to explain such late events. CONCLUSIONS Late and sudden thrombosis after PTCA followed by intracoronary radiotherapy is a new phenomenon in interventional cardiology.
Secrecy-Oriented Transmitter Optimization for Visible Light Communication Systems

Securing visible light communication (VLC) systems with physical-layer technologies has drawn increasing attention. In this paper, we leverage both transmit beamforming and jamming techniques to enhance communication secrecy for a multiple-input single-output (MISO) VLC system with presence of multiple eavesdroppers. The transmit beamformer and jamming precoder are jointly optimized in the sense that the signal-to-noise ratio (SNR) of the legitimate user is maximized subject to maximum SNR constraints imposed on eavesdroppers, as well as light-emitting diode (LED) optical power constraints. Despite the fact that the corresponding optimization problem has a nonconvex fractional form, we are able to determine its locally optimal solution via Charnes-Cooper transformation and minorization-maximization algorithm. Furthermore, we study the extension to a more complicated scenario where perfect channel state information at the transmitter (CSIT) is not available. The superiority of the proposed algorithms is finally verified via simulations.
Transthoracic echocardiography for cardiopulmonary monitoring in intensive care

Background and objective: To evaluate the feasibility of an abbreviated focus assessed transthoracic echocardiographic protocol, consisting of four standardized acoustic views for cardiopulmonary screening and monitoring. Methods: The protocol was applied in 210 patients in a 20-bed multidisciplinary intensive care unit in a university hospital. When inconclusive, an additional transoesophageal echocardiographic examination was performed. Diagnosis, indication, acoustic window, position and value were recorded. Significant pathology, load, dimensions and contractility were assessed. Results: Two-hundred-and-thirty-three transthoracic and four transoesophageal echoes were performed. The protocol provided usable images of the heart in 97% of the patients, 58% subcostal, 80% apical and 69% parasternal. Images through one window were obtainable in 23%, through two windows in 41% and through three windows in 34%. In 227 patients (97.4%) the focus assessed echo protocol contributed positively. In 24.5% of cases the information was decisive, in 37.3% supplemental and in 35.6% supportive. Conclusions: By means of an abbreviated, focus assessed transthoracic echo protocol it is feasible to visualize the haemodynamic determinants for assessment and optimization. One or more useful images are obtainable in 97% of critically ill patients.
Measurements of Serum Levels of Nitrate Ions in Men and Women: Implications of Endothelium‐Derived Relaxing Factor in Blood Pressure Regulation and Atherosclerosis

Summary: As endothelium‐derived nitric oxide (NO) is a potent vasodilator and degraded into nitric ions, we measured serum levels of nitrate (NO‐3) concentrations as an index of endothelium‐derived NO, to assess its role in blood pressure regulation. Because serum NO3− levels in men were significantly elevated compared to those in women, data from these two groups were analyzed separately. In men, multiple regression analysis revealed that NO3− significantly correlated with age, systolic blood pressure, body mass index (BMI), and total cholesterol. Blood pressure correlated with age, BMI, and NO3− with multivariate analysis. In women, NO3− significantly correlated with age, systolic blood pressure, and total cholesterol with a simple correlation. With multiple regression analysis, serum NO3− highly correlated with serum levels of triglyceride and total cholesterol and age. The blood pressure correlated with four parameters, i.e., total cholesterol, age, BMI, and NO3−. In summary, serum NO3‐ levels seem to relate to serum lipids and glucose levels and blood pressure, which strongly suggests that production of endothelium‐derived NO is increased in the atherosclerotic process.
Alternative Approaches to Comparative nth-Degree Risk Aversion

This paper extends the three main approaches to comparative risk aversion—the risk premium approach and the probability premium approach of Pratt (1964) [Risk aversion in the small and in the large. Econometrica 32(1-2):122–136] and the comparative statics approach of Jindapon and Neilson (2007) [Higher-order generalizations of Arrow-Pratt and Ross risk aversion: A comparative statics approach. J. Econom. Theory 136(1):719–728]—to study comparative nth-degree risk aversion. These extensions can accommodate trading off an nth-degree risk increase and an mth-degree risk increase for any m, such that [Formula: see text]. It goes on to show that, in the expected utility framework, all of these general notions of comparative nth-degree risk aversion are equivalent and can be characterized by the concept of (n/m)th-degree Ross more risk aversion of Liu and Meyer (2013) [Substituting one risk increase for another: A method for measuring risk aversion. J. Econom. Theory 148(6):2706–2718]. This paper was accepted by Han Bleichrodt, decision analysis.
The Vmax of the Ca2+-ATPase of Cardiac Sarcoplasmic Reticulum (SERCA2a) Is Not Altered by Ca2+/Calmodulin-dependent Phosphorylation or by Interaction with Phospholamban*

Earlier studies (Hawkins, C., Xu, A., and Narayanan, N. (1994) J. Biol. Chem. 269, 31198-31206) have suggested that the Vmax of Ca2+ uptake is enhanced up to 2-fold through phosphorylation of Ser38 in the cardiac Ca2+-ATPase (SERCA2a) by calmodulin-dependent protein kinase (CaM kinase). It is difficult, however, to determine whether stimulation is caused by phosphorylation of the Ca2+-ATPase or by phosphorylation of phospholamban in cardiac microsomes. We have expressed SERCA2a in HEK-293 cells in the presence or absence of phospholamban and measured the effects on Ca2+ uptake activity of phosphorylation of microsomal proteins by CaM kinase or protein kinase A (PKA). We found no effect on the Vmax of Ca2+ uptake following phosphorylation by CaM kinase or PKA in either the presence or absence of phospholamban. The K0.5 for Ca2+ dependence of Ca2+ transport, however, was shifted following phosphorylation by either CaM kinase or PKA in those microsomes containing both SERCA2a and phospholamban, but not in those expressing only SERCA2a. Thus, we cannot confirm earlier reports of stimulation of SERCA2a activity by CaM kinase II phosphorylation of Ser38. Our studies, however, emphasize the need for adequate controls for measurement of Vmax.
Role of the TRAF Binding Site and NF-κB Activation in Epstein-Barr Virus Latent Membrane Protein 1-Induced Cell Gene Expression

ABSTRACT In this study, we investigated the induction of cellular gene expression by the Epstein-Barr Virus (EBV) latent membrane protein 1 (LMP1). Previously, LMP1 was shown to induce the expression of ICAM-1, LFA-3, CD40, and EBI3 in EBV-negative Burkitt lymphoma (BL) cells and of the epidermal growth factor receptor (EGF-R) in epithelial cells. We now show that LMP1 expression also increased Fas and tumor necrosis factor receptor-associated factor 1 (TRAF1) in BL cells. LMP1 mediates NF-κB activation via two independent domains located in its C-terminal cytoplasmic tail, a TRAF-interacting site that associates with TRAF1, -2, -3, and -5 through a PXQXT/S core motif and a TRADD-interacting site. In EBV-transformed B cells or transiently transfected BL cells, significant amounts of TRAF1, -2, -3, and -5 are associated with LMP1. In epithelial cells, very little TRAF1 is expressed, and only TRAF2, -3, and -5, are significantly complexed with LMP1. The importance of TRAF binding to the PXQXT/S motif in LMP1-mediated gene induction was studied by using an LMP1 mutant that contains alanine point mutations in this motif and fails to associate with TRAFs. This mutant, LMP1(P204A/Q206A), induced 60% of wild-type LMP1 NF-κB activation and had approximately 60% of wild-type LMP1 effect on Fas, ICAM-1, CD40, and LFA-3 induction. In contrast, LMP1(P204A/Q206A) was substantially more impaired in TRAF1, EBI3, and EGF-R induction. Thus, TRAF binding to the PXQXT/S motif has a nonessential role in up-regulating Fas, ICAM-1, CD40, and LFA-3 expression and a critical role in up-regulating TRAF1, EBI3, and EGF-R expression. Further, D1 LMP1, an LMP1 mutant that does not aggregate failed to induce TRAF1, EBI3, Fas, ICAM-1, CD40, and LFA-3 expression confirming the essential role for aggregation in LMP1 signaling. Overexpression of a dominant form of IκBα blocked LMP1-mediated TRAF1, EBI3, Fas, ICAM-1, CD40, and LFA-3 up-regulation, indicating that NF-κB is an important component of LMP1-mediated gene induction from both the TRAF- and TRADD-interacting sites.
Anti‐C1q antibodies in hepatitis C virus infection

Autoantibodies against C1q have been described in many immune‐complex diseases including hypocomplementaemic urticarial vasculitis and systemic lupus erythematosus (SLE). No study has focused on the role of anti‐C1q antibodies in hepatitis C virus (HCV) infection. The aim of this study was (i) to evaluate the prevalence of anti‐C1q antibodies in HCV infection; and (ii) to analyse the association of anti‐C1q antibodies with clinical and biological features of HCV–mixed cryoglobulinaemia (MC) vasculitis. We searched for anti‐C1q antibodies using an enzyme‐linked immunosorbent assay (ELISA) test in 111 HCV patients (75 had cryoglobulin and 23 systemic vasculitis), 60 SLE patients and 109 blood donors. Anti‐C1q antibodies were detected in 26% of HCV patients compared to 10% of healthy donors (P < 0·01), and 38% in patients with SLE. Although there was a higher prevalence of anti‐C1q antibodies among HCV patients with type III cryoglobulin (50%, P < 0·01), the overall prevalence of anti‐C1q antibodies was similar in HCV patients being cryoglobulin‐positive or cryoglobulin‐negative (26%versus 25%, P = 0·98). A significant association was found between anti‐C1q antibodies and low C4 fraction of complement (P < 0·05). No association was found between anti‐C1q antibodies and HCV genotype, severity of liver disease or with specific clinical signs of HCV–MC vasculitis. This study shows an increased prevalence of anti‐C1q antibodies in HCV‐infected patients. Anti‐C1q antibodies were associated with low C4 levels. No association was found between anti‐C1q antibodies and HCV–MC vasculitis, nor between anti‐C1q antibodies and cryoglobulinaemia.
Effect of predigestion factors on the apparent digestibility of protein for swine determined by the Mobile Nylon Bag Technique.

Five Yorkshire x Lacombe barrows (45 kg initial wt) fitted with duodenal cannulas approximately 10 cm from the pyloric sphincter were used to determine the influence of the pH of the predigestion solution (pH 1.0, 1.5, 2.0 or 2.5), pepsin activity (189 vs 377 IU/liter) and duration of predigestion (0, 1.5, 2.5 or 4.0 h) on the apparent digestibility of the protein in soybean meal (SBM), meal and bone meal (MBM) or canola meal (CM) determined with the Mobile Nylon Bag Technique (MNBT). An additional six barrows were used to determine protein digestibility by conventional methods. Protein digestibilities determined using conventional digestibility techniques were 93.1 +/- . 7, 79.1 +/- 1.8 and 79.3 +/- 1.4% for the SBM, MBM and CM diets, respectively. Protein digestibilities determined with the MNBT were highest at pH 2.0 for all three protein sources. Increasing pepsin activity from 189 to 377 IU/liter resulted in a slight increase in the digestibility of SBM and CM, but not of MBM. The absence of predigestion (0 h) resulted in a dramatic reduction in protein digestibility; predigestion times of 1.5 or 2.5 h usually resulted in lower protein digestibilities than did a predigestion time of 4.0 h. The closest agreement between results obtained by the MNBT and conventional digestibility studies occurred with a pH of 2.0, a predigestion time of 4.0 h and a pepsin activity of 377 IU/liter.