Miracle-dz/UniFAR-FTUs huggingface dataset:
Salmonella Populations inside Host Cells

Bacteria of the Salmonella genus cause diseases ranging from gastroenteritis to life-threatening typhoid fever and are among the most successful intracellular pathogens known. After the invasion of the eukaryotic cell, Salmonella exhibits contrasting lifestyles with different replication rates and subcellular locations. Although Salmonella hyper-replicates in the cytosol of certain host cell types, most invading bacteria remain within vacuoles in which the pathogen proliferates at moderate rates or persists in a dormant-like state. Remarkably, these cytosolic and intra-vacuolar intracellular lifestyles are not mutually exclusive and can co-exist in the same infected host cell. The mechanisms that direct the invading bacterium to follow the cytosolic or intra-vacuolar “pathway” remain poorly understood. In vitro studies show predominance of either the cytosolic or the intra-vacuolar population depending on the host cell type invaded by the pathogen. The host and pathogen factors controlling phagosomal membrane integrity and, as consequence, the egress into the cytosol, are intensively investigated. Other aspects of major interest are the host defenses that may affect differentially the cytosolic and intra-vacuolar populations and the strategies used by the pathogen to circumvent these attacks. Here, we summarize current knowledge about these Salmonella intracellular subpopulations and discuss how they emerge during the interaction of this pathogen with the eukaryotic cell.
Patterns of human growth.

From the combination of knowledge and actions, someone can improve their skill and ability. It will lead them to live and work much better. This is why, the students, workers, or even employers should have reading habit for books. Any book will give certain knowledge to take all benefits. This is what this patterns of human growth tells you. It will add more knowledge of you to life and work better. Try it and prove it.
Towards a technology and agglomeration platform of the colombian caribbean shipyard sector

The need to create the conditions to improve the productivity and competitiveness of the shipyard sector in the Caribbean Region, is framed in the greatest challenges and technological advances, especially in the adoption of technologies in the naval industry, which implies the making of investment decisions Based on the development of research and development activities. Agglomeration (clusterization) tend to define articulating and animating agents that allow the establishment of a technological and competitiveness agenda (technological platform) for the adoption of a new model based on innovation and technological development. The world-wide experiences of the role of the generation of technologies are varied, not only from the private but also public scope for the competitive improvement in the shipyard sector. In the Caribbean region, thanks to COTECMAR's trajectory, some of its capabilities could be oriented to define, on the one hand, the medium- and long-term strategy for the shipyard sector, on the other, to establish a market and technology intelligence center and finally to define itself as An animator between the different public and private actors that lead to the development of important technology projects based on innovative processes of transfer and commercialization, without losing its mission of being a guarantor of National Security and Defense.
Immunoregulation Mother‐Fetus/Newborn, a RoIe for Anti‐idiotypic Antibodies

The presence of antibodies of fe tal origin in the newborn In recent studies of the ontogeny of secretory immunity in man it was found that secretory IgA (SIgA) as well as IgM (SIgM) appeared in the saliva of the newborn ( I ) . No proof was found that these antibodies originated from the mother. Actually evidence against this possibility appeared from the investigation of the newborn of a mother with hypogammaglobulinemia lacking IgA and IgM but given IgG as immunoglobulin prophylaxis. The newborn infant had IgA and IgM antibodies of the secretory type in the saliva and meconium against a pool of E. wli 0 antigens and/or poliovirus type 1 (1). The poliovirus was chosen as a critical antigen since it was most unlikely that the fetus and the mother could have been exposed to this antigen. Only vaccination with inactivated poliovirus vaccine is permitted in Sweden, therefore there are no vaccine strains in the country. This vaccination which covers about 99 % of the population, has eliminated wild poliovirus strains, except a few isolated imports. The presence of antibodies to the poliovirus in a newborn in the absence of the antigen makes it necessary to find another explanation for the induction of these antibodies.
Financial accessibility and inclusive value systems for finance, tax and accounting practices: Advocacy and design recommendations for accessible practices and disability tax rights.

There is a proportionally significant marginalized aging and disabled population in Canada from perspectives of equitable financial means and access. While in recent years there has been increased effort from the federal and provincial governments through the Income Tax Act of ongoing incremental tax provisions and adjustments in order to integrate and provide equal opportunity to people with disabilities, these efforts do not reflect a comprehensive and coordinated approach, or a coherent disability tax strategy. Issues such as the cost outlay of disabilities (medication, support, and treatments), access and stability in the labor force, caregiver and family support, retraining and higher education and general income support are all outstanding issues in need of much reform [20]. It is therefore necessary to persist in efforts to make positive change and actively build on prior political successes to continue to push for tax policy reform to promote equal access and integration within the broader society. This report investigates design strategies and opportunities for influencing dialogue between the federal departments and agencies, advocacy groups and the disadvantaged general public, based on a deep understanding of the impact of disabilities on families, the disability tax provisions and existing support mechanisms in order to arrive at meaningful recommendations to reduce social gaps and to reduce economic inequality.
Propofol’s Effects on the Fetal Brain for Non-Obstetric Surgery

While the use of Propofol has been increasing in usage for general surgical procedures since its release to market, there has been little work done on its potential link to neurotoxicity in humans. Only recently, following the release of a warning label from the United States Food and Drug Administration (USFDA) regarding a potential link to “neurotoxicity” in the neonate, did the surgical and anesthesiology communities become more aware of its potential for harm. Given the widespread use of this drug in clinical practice, the warning label naturally raised controversy regarding intrapartum Propofol usage. While intended to generate further studies, the lack of a viable anesthetic alternative raises issues regarding its current usage for surgical procedures in pregnant women. To answer the question whether current evidence is supportive of Propofol usage at its current levels in pregnant women, this review summarizes available evidence of fetal Propofol exposure in animal studies.
Speech enhancement using optimal non-linear spectral amplitude estimation

A speech enhancement system which utilizes an optimal (in the minimum mean square error sense) short-time spectral amplitude estimator is described. The derivation of the optimal estimator is based on modeling speech as a quasi-periodic signal, and on applying spectral decomposition. The optimal spectral amplitude estimator and a recently developed vector spectral subtraction amplitude estimator, are round to be nearly equivalent. The optimal spectral amplitude estimator coincides with a Wiener spectral amplitude estimator at high signal to noise ratio (SNR) values, and is found to be superior to it at low SNR values. The enhanced speech obtained by using the proposed system, is less spectrally distorted, although contains some more residual noise, than the enhanced speech obtained by using the Wiener spectral amplitude estimator, in the same system. In addition, it is free of the "musical noise" characteristic to the spectral subtraction algorithm. Both systems, the proposed one and spectral subtraction, have approximately the same complexity.
A study on the efficacy of body-mind-spirit group therapy for patients with breast cancer.

AIMS AND OBJECTIVES This study aims to understand the effects of culturally enriched body-mind-spirit group therapy on anxiety, depression and holistic well-being among women with breast cancer and to examine patients' views on what aspects of group therapy worked to enhance their health. DESIGN The study was designed using multiple methods, which consisted of a randomised controlled trial and a focus group interview. METHODS A total of 16 subjects in the control group received the standard care of a physician's treatment at the outpatient department. In addition to standard care, 12 subjects in the experimental group received 10 sessions of weekly body-mind-spirit group therapy for 180 minutes each. This therapy integrates concepts and practices of traditional Chinese medicine and Western medicine (e.g. positive psychology and forgiveness therapy). The subjects in the experimental group were invited to participate in a focus group interview regarding their perceptions of the change mechanisms that occurred in group therapy. RESULTS The results of analysis of covariance indicated that after a two-month trial, there was a similarity between the experimental and control groups in reducing the scores of Beck depression inventory and increasing the scores of body-mind-spirit well-being. However, subjects in the experimental group had a better reduction of the scores of state anxiety inventory than subjects in the control group. The qualitative analysis yielded eight domains: (i) imparting of information, (ii) interpersonal learning, (iii) catharsis, (iv) universality, (v) group cohesiveness, (vi) altruism, (vii) instillation of hope and (viii) existential factors. These domains illustrate how the therapeutic effects of group therapy worked to reduce patients' anxiety. CONCLUSION The culturally sensitive body-mind-spirit group therapy reduced anxiety among outpatients with breast cancer. RELEVANCE TO CLINICAL PRACTICE The involvement of mental health nurses in providing group therapy for cancer patients could enhance the quality of care in psycho-ontological nursing.
Value Creating Determinants Of Enterprise Risk Management And Its Economic Value Added

The aim of this research paper is to gain insights into the value creating determinants of enterprise risk management (ERM) implementation and its economic value added (EVA). Data for this study was collected using questionnaire survey and published reports of public listed companies. Empirical examination of the pertinent value creation hypotheses involves bivariate correlation and regression analysis in examining the association and impact of ERM implementation towards various factors of EVA measurement as well as value maximization elements. The results of the study reveal that ERM implementation significantly enhances the net operating profit after tax, return on invested capital; whilst reduces the cost of financial distress, cost of external financing, informational asymmetries, agency problem and the weighted average cost of capital of the companies. Nevertheless, the findings show insignificant relationship between ERM implementation and lowering the tax burden of the companies. This study contributes to the existing literature on the value maximization theory of ERM by linking it with the measurement factors for economic value added analysis. © 2018 Published by Future Academy www.FutureAcademy. org.UK
Low NK Cell Activity in Chronic Fatigue Syndrome (CFS) and Relationship to Symptom Severity

Background: Natural killer (NK) cells act as an immune surveillance against invading pathogens and tumors. NK cell cytotoxicity (NKCC) has been reported to be decreased in patients with CFS.Methods: The objective of this review was to conduct an analysis of available publications that reported NKCC data in CFS in order to evaluate any relationships to case definitions used to define CFS and symptom severity.Results: Of 17 studies that evaluated NKCC in patients with CFS, defined using the CDC 1988 and/or 1994 case definition (CD), 88% (15/17) concluded that NKCC was decreased in CFS patients compared to normal controls. The NKCC decrease was seen using two established methods, 51Cr release (11/13) and flow cytometry (4/4). The mean percent decrease in NKCC using the CDC 1988 CD (66.3%) was significantly greater than that using the CDC 1994 CD (49.7%) (p 0.5). Finally, seven studies investigating the ability of various agents to augment NKCC in patients with CFS showed increases of NKCC with both in vitro exposure (4/5) and in vivo exposure using randomized trials (2/2). Conclusions: Low NKCC is commonly seen in CFS and is associated with increase symptom severity.
What risks do exchange-traded funds pose?

There has been remarkable growth in the exchange-traded fund (ETF) market over the past decade. For many investors in equities and bonds, ETFs have become a preferred investment vehicle, providing low-cost exposure to diversified portfolios through the tracking of an index, while also allowing frequent on-market trading. Notwithstanding these clear benefits to investors, ETFs may pose some market risks. Among the main risks is that heavy trading of ETFs adds to co-movement and volatility in security prices. Price dynamics in periods of stress could also be affected by investor expectations about continued high liquidity or possible impairment of the ETF primary-secondary market trading mechanism. Risks may become more acute if complex ETF structures were to grow to a bigger share of activity.
Synthesis and characterization of diblock and gel-forming pentablock copolymers of tertiary amine methacrylates, poly(ethylene glycol), and poly(propylene glycol)

Novel pH-sensitive gel-forming pentablock copolymers based on commercially available Pluronic (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), PEO-b-PPO-b-PEO) triblock copolymers and cationic diblock copolymers based on poly(ethylene glycol) methyl ether (PEGME) were synthesized by oxyanionic polymerization. Polymerization of the cationic moiety, poly((diethylamino)ethyl methacrylate), PDEAEM, was initiated by a difunctional potassium alcoholate of the triblock Pluronic copolymer F127 (PEO106−PPO69−PEO106) or PEGME. The difunctionality of the initiation using the triblock macroinitiator, indicating formation of a pentablock copolymer rather than a tetrablock copolymer, was verified by functionalized termination of the living polymer chains. Critical micellization temperatures (cmt) of the synthesized polymers were obtained from differential scanning calorimetry for the pentablock materials. The pentablock copolymers retained the thermoreversible gel-forming properties of Pluronic F12.
Possible Applications of Industry 4.0 Based on Customer Relationship Management in Bakery

Production of bakery products went through a long and gradual transformation from individual, craft to modern industrial production. Today, the production of bakery products has been developed by mass high-automated industrial production. Although production plants that find their economic justification mostly on the expenditure side of reduction of production costs and production processes, the modern business requires a change of the income side, where development of relations with consumers has more important role. Production of bakery products had all the features of mass production until recently. Due to the importance of bakery products in the nutrition of people, particularly in developed parts of the world, demand for bakery products could be considered as non-elastic, since the price, quality and range of bakery products were basically irrelevant to the volume of demand for these products. However, at the end of the twentieth century the purchasing power of the population, as well as the level of information, knowledge and self-awareness, significantly influenced the consumption of bakery products. The modern consumer changes the structure of food in the nutrition and he is no longer satisfied with a mass-produced product, but requires a product that is “tailored” according to his needs. The manufacturing capabilities of modern, numerically controlled machines that make Industry 4.0, allow the production of “tailored” products according to the needs of individual consumers. Consequently, transformation and transition from mass to individualized bakery product production requires a scientific and systematic approach.
Creating a Culture to Promote Shared Decision Making at Group Health

Copyright 2013 by the National Academy of Sciences. All rights reserved. The views expressed in this commentary are those of the authors and not necessarily of the authors’ organization or of the Institute of Medicine. The commentary is intended to help inform and stimulate discussion. It has not been subjected to the review procedures of the Institute of Medicine and is not a report of the Institute of Medicine or of the National Research Council. Creating a Culture to Promote Shared Decision Making at Group Health
Multiple failure analysis with restoration paths matrix

The paper studies the concept of restoration paths (RP) matrix for analysis and performance evaluation of link restoration schemes. The RP matrix provides a very useful tool for computing single, double and multiple failure analysis of network restorability. It can be constructed for any link restoration scheme, regardless of unique scheme architecture or pattern. For this reason, the RP matrix can be used to compare various link restoration schemes. We present a description of the RP matrix, provide examples of it for well-known network architectures, and compute mathematical formulas to calculate various performance parameters of the network from network topology info and the RP matrix.
Endotoxin levels in settled airborne dust in European schools: the HITEA school study.

Indoor exposure to microbial agents is known to influence respiratory health. Besides home exposure, exposure in schools can affect respiratory health. In this study, we measured endotoxin in settled dust in primary schools in three European countries from three different geographical regions with different climates. Our aim was to characterize endotoxin levels in primary schools and evaluate associations with potential determinants. Endotoxin levels were repeatedly assessed in 23 schools in Spain (n = 7), the Netherlands (n = 10), and Finland (n = 6) using electrostatic dustfall collectors. In total, 645 measurements were taken in 237 classrooms. Endotoxin levels differed significantly between countries; Dutch schools had the highest levels, while Finnish schools showed the lowest levels. In each country, differences in endotoxin levels were observed between schools and over the sampling periods. Estimates improved after adjustment for sampling period. Factors affecting endotoxin levels in a school differed per country. In general, endotoxin levels were higher in lower grades and in classrooms with higher occupancy. School endotoxin levels may contribute significantly to total endotoxin exposure in children and teachers. As the correlation between the repeated measurements is reasonable, single endotoxin measurements form a reasonable basis for estimating annual endotoxin levels in schools.
Does corporate sustainability practices have an impact on financial performance: A study based on BIST manufacturing firms

Purpose- Corporate Sustainability notion has become very important in recent years with sustainable development, which is defined as fulfillment of current needs without risking fulfillment of future generations' needs. Especially in the last two decades, the relationship between financial performance and corporate sustainability has been questioned extensively in large masses particularly business and academic world. The purpose of this study is to analyze the corporate sustainability practices and its impact on financial performance. Methodology - It focuses on relationship between corporate sustainability practices and financial performance. In order to reach this aim corporate sustainability checklist is established and companies are classified according to their sustainability levels. Publicly traded companies from BIST 100 (excluding finance sector) are used as a sample. Data is gathered from theirs annual reports for the years between 2012-2017. Findings- MANOVA analysis is used to analyze the relationship between the sustainability levels and the financial performance indicators. The results implied that sustainability levels have statistically significant effect between the group means of 3 variables. These are Current Ratio, Gross Profit Margin and Corporate Governance Index. For Current Ratio variable, there is a significant difference between sustainable and least sustainable category for 10 % significance level. For CG Index variable, there is a significant difference between most sustainable and sustainable category and most sustainable and least sustainable category for 5 % significance level. For Gross Profit Margin variable, there is a significant difference between most sustainable and sustainable category for 5 % significance level. Conclusion- In many studies it is found that there is a positive relationship between corporate social sustainability and firm financial performance. Our study supports that companies incorporate sustainability issues into their business operations are better able to leverage their resources toward stronger financial performance and shareholder value creation.We were able find a significant relationship between Current Ratio, Gross Profit Margin and Corporate Governance Index. The paper contributes to the literature by offering a more holistic approach to corporate sustainable performance measurement and its relationship between financial performance.
Avoiding steroids in solid organ transplantation

The excellent results obtained today in solid-organ transplantation allow the envisaging of an improvement in long-term quality of life with a functioning graft. One way for this to be achieved is by the reduction, or even better, the avoidance, of steroid-based immunosuppression. Avoidance of steroids is indeed known to enhance the physical and psychological well being of the allograft recipient. This paper reviews the current status of steroid-free immunosuppression in renal, pancreatic, hepatic, intestinal, and cardiac transplantation.
Confocal reflectance imaging of folliculitis in vivo: correlation with routine histology

Near‐infrared confocal reflectance microscopy (CM) is a high‐resolution non‐invasive imaging technique with promising future in dermatology. A pustular lesion from a 35‐year‐old male with a known history of folliculitis was non‐invasively viewed with CM and later biopsied. Optical sections were correlated with routine histology, This optical technique allows us to view non‐invasively transverse skin sections to a conirolled depth in real time. In the CM images, tissue can be visualized with cellular and subeellular detail as shown by imaging infiltrating neutrophils (PMNs) within the subcorneal pustule of a superficial folliculitis in vivo.