Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic Value of Pre-Infarction Angina Combined with Mean Platelet Volume to Lymphocyte Count Ratio for No-Reflow and Short-Term Mortality in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Background The aim of the present study was to investigate the clinical predictive value of pre-infarction angina (PIA) combined with mean platelet volume to lymphocyte count ratio (MPVLR) for no-reflow phenomenon and short-term mortality in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). Material/Methods A total of 1009 STEMI patients who had undergone PCI were enrolled and subdivided into 4 groups based on the occurrence of PIA and the presence of MPVLR above or below the cutoff value. Analysis of the predictors of the no-reflow phenomenon and 90-day mortality was conducted. Further, evaluation and comparison of the clinical predictive value of PIA, MPVLR, and their combination were done. Results Both MPVLR (odds ratio [OR]=1.476, 95% confidence interval [CI]: 1.401 to 1.756, P<0.001; hazard ratio [HR]=1.430, 95% CI: 1.287 to 1.643, P<0.001) and PIA (OR=0.905, 95% CI: 0.783 to 0.986, P<0.001; HR=0.878, 95% CI: 0.796 to 0.948, P<0.001) were independent predictors of no-reflow phenomenon and 90-day mortality. Spearman’s rank correlation test revealed that MPVLR (r=−0.297, P<0.001), monocyte to lymphocyte count ratio (MLR) (r=−0.211, P<0.001) and neutrophil to lymphocyte count ratio (NLR) (r=−0.389, P<0.001) in peripheral blood were significantly negatively correlated with postoperative left ventricular ejection fraction (LVEF). Upon comparing the area under curve (AUC), the MPVLR combined with PIA achieved better performance in differentiating no-reflow phenomenon (AUC=0.847, 95% CI: 0.821 to 0.874) and 90-day mortality (AUC=0.790, 95% CI: 0.725 to 0.855), than the GRACE score, MPVLR and PIA alone, and had similar performance to all other pairwise combinations of the GRACE score, MPVLR and PIA. Conclusions High MPVLR and PIA were independent predictors of the no-reflow phenomenon and 90-day mortality in patients with STEMI after PCI. Moreover, Combined application of MPVLR and PIA can effectively predict the occurrence of the no-reflow phenomenon and 90-day mortality.
Analysis of Cold-Developed vs. Cold-Acclimated Leaves Reveals Various Strategies of Cold Acclimation of Field Pea Cultivars

Peas (Pisum sativum L.) belong among the world’s oldest domesticated crops, serving as a source of proteins, complex carbohydrates, vitamins and minerals. Autumn sowing allows a higher biomass production as well as the avoidance of the drought and heat stresses of late spring. However, the character of European continental winters limits plant growth and development through cold stress. This work sought parameters that reflect the cold tolerance of pea plants and consequently to suggest an afila-type pea cultivar with resilience to European continental winters. For this purpose, we employed indoor remote sensing technology and compared the 22-day-long acclimation to 5 °C of four pea cultivars: Arkta, with normal leaves and the known highest cold resistance to European continental winters, and Enduro, Terno and CDC Le Roy, all of the afila type. Besides evaluation of shoot growth rate and quenching analysis of chlorophyll fluorescence (ChlF) by imaging methods, we measured the chlorophyll content and ChlF induction with a nonimaging fluorometer. Here we show that the acclimation to cold of the Arkta exhibits a different pattern than the other cultivars. Arkta showed the fastest retardation of photosynthesis and shoot growth, which might be part of its winter survival strategy. Terno, on the other hand, showed sustained photosynthetic performance and growth, which might be an advantageous strategy for spring. Surprisingly, Enduro showed sustained photosynthesis in the stipules, which transferred and acclimated to 5 °C (cold-acclimated). However, of all the cultivars, Enduro had the strongest inhibition of photosynthesis in new stipules that developed after the transition to cold (cold-developed). We conclude that the parameters of ChlF spatial imaging calculated as averages from whole plants are suboptimal for the characterization of various cold acclimation strategies. The most marked changes were obtained when the new cold-developed leaves were analyzed separately from the rest of the plant.
Treatment Algorithm for Mild and Moderate-to-Severe Ulcerative Colitis: An Update

Background: Patient care in ulcerative colitis (UC) remains challenging despite an array of established treatment options and emerging new therapies. The management of UC therapy should be guided by the endoscopic extent of inflammation, disease severity, and prognostic factors of poor outcome. Complete remission, defined as durable symptomatic and endoscopic remission without corticosteroid therapy, is the desired treatment goal. Summary: This review focuses on treatment recommendations for different clinical scenarios in moderate-to-severe UC: Active UC of any extent not responding to aminosalicylates, steroid-dependent UC, steroid-refractory UC, immunomodulator-refractory UC, and acute severe UC. Comprehensive treatment algorithms for daily clinical practice were developed based on published guidelines and current literature. Key Messages: While current treatment options including a number of biologicals and small molecules have evolved UC treatment to achieve sustained remission in a majority of patients, upcoming treatment options with different molecular pathways and different modes of actions will further increase the need for personalized medicine.
Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine

There is a trend to use medicinal plants for primary medical care or as dietary supplements; however, the safety of many of these plants has not been studied. The objective of this work was to determine the toxic effect of the aqueous extract of Calea ternifolia (C. zacatechichi), known popularly as “dream herb” in vivo and in vitro in order to validate its safety. In vivo, the extract had moderate toxicity on A. salina. In vitro, the extract induced eryptosis of 73% at a concentration of 100 μg·mL−1 and it inhibited CYP3A by 99% at a concentration of 375 μg/mL. After administering 8.5 mg/kg of C. ternifolia to rats, we found a reduction in platelets and leukocytes and an increase in urea and the liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Histological analysis showed spongiform changes in the proximal tubules of renal tissue and a lymphoid infiltrate in liver tissue. This plant is used in the treatment of diabetes, and it is commercialized as a dietary supplement in several countries. Our results show renal and hepatic toxicity; therefore, more profound research on the toxicity of this plant is needed.
Oxygenated and Nitrated Polycyclic Aromatic Hydrocarbons in Ambient Air—Levels, Phase Partitioning, Mass Size Distributions, and Inhalation Bioaccessibility

Among the nitrated and oxygenated polycyclic aromatic hydrocarbons (NPAHs and OPAHs) are some of the most hazardous substances to public health, mainly because of their carcinogenicity and oxidative potential. Despite these concerns, the concentrations and fate of NPAHs and OPAHs in the atmospheric environment are largely unknown. Ambient air concentrations of 18 NPAHs, 5 quinones, and 5 other OPAHs were determined at two urban and one regional background sites in central Europe. At one of the urban sites, the total (gas and particulate) concentrations of Σ10OPAHs were 10.0 ± 9.2 ng/m3 in winter and 3.5 ± 1.6 ng/m3 in summer. The gradient to the regional background site exceeded 1 order of magnitude. Σ18NPAH concentrations were typically 1 order of magnitude lower than OPAHs. Among OPAHs, 9-fluorenone and (9,10)-anthraquinone were the most abundant species, accompanied by benzanthrone in winter. (9,10)-Anthraquinone represented two-thirds of quinones. We found that a large fraction of the target substance particulate mass was carried by submicrometer particles. The derived inhalation bioaccessibility in the PM10 size fraction is found to be ≈5% of the total ambient concentration of OPAHs and up to ≈2% for NPAHs. For 9-fluorenone and (9,10)-anthraquinone, up to 86 and 18%, respectively, were found at the rural site. Our results indicate that water solubility could function as a limiting factor for bioaccessibility of inhaled particulate NPAHs and OPAHs, without considerable effect of surfactant lipids and proteins in the lung lining fluid.
To share or withhold? Contract negotiation in buyer-supplier-supplier triads

Purpose This paper seeks to fill the literature gap that lacks of exploring negotiation strategy with competing partners under asymmetric production-cost information. The purpose of this paper is to examine firms’ optimal contract negotiation strategies in buyer–supplier–supplier triads where there are concurrent negotiations between the retailer and two competing manufacturers. Design/methodology/approach The authors consider a two-echelon supply chain, in which the retailer has the option of segmented or unified negotiation policy, whereas the two competing manufacturers can withhold or share production cost information in the negotiation. Based on game theory, the authors derive the manufacturers’ optimal wholesale prices and the retailer’s optimal retail prices with eight possible scenarios. Optimal strategic choices and operational decisions are then explored through the comparative analysis of equilibriums of eight possible scenarios. Findings The authors find that the retailer will adopt different negotiation strategies depending on manufacturers’ decisions on sharing or withholding their production-cost information. When both manufacturers share their production-cost information, the retailer will adopt a unified negotiation policy. The high-efficiency manufacturer should adopt the same information-sharing strategy as the low-efficiency manufacturer in order to gain more profit. Originality/value The modelling helps to bring further clarity in supply chain contract negotiation by offering a conceptual framework to enhance our understanding of the effects of information-sharing strategy and negotiation policy in the negotiation process form the perspectives of all engaging parties. Managerial insights derived from the research will enable retailers and manufacturers to make informed and better strategic and operational decisions to improve market competitiveness.
Social Cognition in Individuals with Progressive Multiple Sclerosis: A Pilot Study Using TASIT-S

Abstract Objective: Individuals with multiple sclerosis (MS) can have difficulty on tasks requiring social cognition, including Theory of Mind (ToM) and facial affect recognition. However, most research on social cognition in MS has focused on Relapsing–Remitting MS; less is known about deficits in individuals with progressive MS. This pilot study examined the social cognitive abilities of individuals with progressive MS on a dynamic social cognition task: The Awareness of Social Inference Test – Short Form (TASIT-S). Methods: Fifteen individuals with progressive MS and 17 healthy controls performed TASIT-S, which includes 3 subtests assessing facial affect recognition and ToM. Results: The MS group was impaired on all subtests of TASIT-S, including Emotion Evaluation, Social Inference – Minimal, and Social Inference – Enriched, which examine facial affect recognition and ToM. Deficits on TASIT-S were significantly correlated with several cognitive abilities including working memory, learning memory, and verbal IQ. Conclusions: Our findings suggest individuals with progressive MS were impaired across multiple social cognition domains as assessed by the TASIT-S. Furthermore, social cognitive abilities were related to cognitive abilities such as visuospatial memory and executive abilities. Results are discussed in terms of social cognition deficits in MS and how they relate to cognitive abilities.
Onset of Regular Smoking Before Age 21 and Subsequent Nicotine Dependence and Cessation Behavior Among US Adult Smokers

This study assessed the association of regular smoking initiation before age 21 years with nicotine dependence and cessation behaviors among US adult smokers. Data came from the 2014–2015 Tobacco Use Supplement to the Current Population Survey. We found that onset of regular smoking at age 18 to 20 years was associated with higher odds of nicotine dependence and lower odds of attempting and intending to quit. These outcomes were observed with regular smoking initiation at age 18 to 20 as well as before age 18, suggesting that efforts to prevent access to tobacco products before age 21 could reduce nicotine addiction and promote cessation later in life.
Does Time-Delay Feedback Matter to Small Target Motion Detection Against Complex Dynamic Environments?

Discriminating small moving objects in complex visual environments is a significant challenge for autonomous micro robots that are generally limited in computational power. Relying on well-evolved visual systems, flying insects can effortlessly detect mates and track prey in rapid pursuits, despite target sizes as small as a few pixels in the visual field. Such exquisite sensitivity for small target motion is known to be supported by a class of specialized neurons named as small target motion detectors (STMDs). The existing STMD-based models normally consist of four sequentially arranged neural layers interconnected through feedforward loops to extract motion information about small targets from raw visual inputs. However, feedback loop, another important regulatory circuit for motion perception, has not been investigated in the STMD pathway and its functional roles for small target motion detection are not clear. In this paper, we assume the existence of the feedback and propose a STMD-based visual system with feedback connection (Feedback STMD), where the system output is temporally delayed, then fed back to lower layers to mediate neural responses. We compare the properties of the visual system with and without the time-delay feedback loop, and discuss its effect on small target motion detection. The experimental results suggest that the Feedback STMD prefers fast-moving small targets, while significantly suppresses those background features moving at lower velocities.
Hardware-Conscious Stream Processing

Data stream processing systems (DSPSs) enable users to express and run stream applications to continuously process data streams. To achieve realtime data analytics, recent researches keep focusing on optimizing the system latency and throughput. Witnessing the recent great achievements in the computer architecture community, researchers and practitioners have investigated the potential of adoption hardware-conscious stream processing by better utilizing modern hardware capacity in DSPSs. In this paper, we conduct a systematic survey of recent work in the field, particularly along with the following three directions: 1) computation optimization, 2) stream I/O optimization, and 3) query deployment. Finally, we advise on potential future research directions.
Alpha-Linolenic Acid-Enriched Butter Promotes Fatty Acid Remodeling and Thermogenic Activation in the Brown Adipose Tissue

Supplementation with n-3 long-chain (LC) polyunsaturated fatty acids (PUFA) is known to promote thermogenesis via the activation of brown adipose tissue (BAT). Agricultural products that are biofortified with α-linolenic acid (ALA), the precursor of n-3 LC PUFA, have been launched to the market, but their impact on BAT function is unknown. This study aimed to evaluate the effects of ALA-biofortified butter on lipid metabolism and thermogenic functions in the BAT. C57BL/6 mice were fed a high-fat diet containing ALA-biofortified butter (n3Bu, 45% calorie from fat) for ten weeks in comparison with the isocaloric high-fat diets prepared from conventional butter or margarine. The intake of n3Bu significantly reduced the whitening of BAT and increased the thermogenesis in response to acute-cold treatment. Also, n3Bu supplementation is linked with the remodeling of BAT by promoting bioconversion into n-3 LC PUFA, FA elongation and desaturation, and mitochondrial biogenesis. Taken together, our results support that ALA-biofortified butter is a novel source of n-3 PUFA, which potentiates the BAT thermogenic function.
Modelling pathogen spread in a healthcare network: Indirect patient movements

Inter-hospital patient transfers (direct transfers) between healthcare facilities have been shown to contribute to the spread of pathogens in a healthcare network. However, the impact of indirect transfers (patients re-admitted from the community to the same or different hospital) is not well studied. This work aims to study the contribution of indirect transfers to the spread of pathogens in a healthcare network. To address this aim, a hybrid network–deterministic model to simulate the spread of multiresistant pathogens in a healthcare system was developed for the region of Lower Saxony (Germany). The model accounts for both, direct and indirect transfers of patients. Intra-hospital pathogen transmission is governed by a SIS model expressed by a system of ordinary differential equations. Our results show that the proposed model reproduces the basic properties of healthcare-associated pathogen spread. They also show the importance of indirect transfers: restricting the pathogen spread to direct transfers only leads to 4.2% system wide prevalence. However, adding indirect transfers leads to an increase in the overall prevalence by a factor of 4 (18%). In addition, we demonstrated that the final prevalence in the individual healthcare facilities depends on average length of stay in a way described by a non-linear concave function. Moreover, we demonstrate that the network parameters of the model may be derived from administrative admission/discharge records. In particular, they are sufficient to obtain inter-hospital transfer probabilities, and to express the patients’ transfers as a Markov process. Using the proposed model, we show that indirect transfers of patients are equally or even more important as direct transfers for the spread of pathogens in a healthcare network.
Lexical Sememe Prediction using Dictionary Definitions by Capturing Local Semantic Correspondence

Sememes, defined as the minimum semantic units of human languages in linguistics, have been proven useful in many NLP tasks. Since manual construction and update of sememe knowledge bases (KBs) are costly, the task of automatic sememe prediction has been proposed to assist sememe annotation. In this paper, we explore the approach of applying dictionary definitions to predicting sememes for unannotated words. We find that sememes of each word are usually semantically matched to different words in its dictionary definition, and we name this matching relationship local semantic correspondence. Accordingly, we propose a Sememe Correspondence Pooling (SCorP) model, which is able to capture this kind of matching to predict sememes. We evaluate our model and baseline methods on a famous sememe KB HowNet and find that our model achieves state-of-the-art performance. Moreover, further quantitative analysis shows that our model can properly learn the local semantic correspondence between sememes and words in dictionary definitions, which explains the effectiveness of our model. The source codes of this paper can be obtained from this https URL.
Sugarcane Bagasse as an Efficient Biosorbent for Methylene Blue Removal: Kinetics, Isotherms and Thermodynamics

Adsorption in biomass has proven to be a cost-effective option for treatment of wastewater containing dyes and other pollutants, as it is a simple and low cost technique and does not require high initial investments. The present work aimed to study the adsorption of methylene blue dye (MB) using sugarcane bagasse (SCB). The biomass was characterized by scanning electron microscopy (SEM). Adsorption studies were conducted batchwise. Kinetics, adsorption isotherms, and thermodynamics were studied. The results showed that SCB presented a maximum adsorption capacity of 9.41 mg g−1 at 45 °C after 24 h of contact time. Adsorption kinetics data better fitted the pseudo-second order model, indicating a chemical process was involved. The Sips’s three-parameter isotherm model was better for adjusting the data obtained for the adsorption isotherms, indicating a heterogeneous adsorption process. The process showed to be endothermic, spontaneous, and feasible. Therefore, it was concluded that SCB presented as a potential biosorbent material for the treatment of MB-contaminated waters.
Long non-coding RNA Ftx promotes osteosarcoma progression via the epithelial to mesenchymal transition mechanism and is associated with poor prognosis in patients with osteosarcoma.

OBJECTIVE Long non-coding RNA Ftx (lncRNA Ftx) is involved in a variety of cancers. However, the association between lncRNA Ftx and osteosarcoma is still unclear. In this study, we investigated the correlation between lncRNA Ftx and osteosarcoma, and the regulative effect of Ftx on the migration and invasion of osteosarcoma cells, as well as its molecular mechanism. METHODS Expression levels of lncRNA Ftx in osteosarcoma tissues and adjacent non-tumor corresponding tissues (ANCTs) were detected using quantitative real-time PCR (qRT-PCR). Differences in patient survival were determined by the Kaplan-Meier method and a log-rank test. The Cox regression analysis was used for univariate and multivariate analyses of prognostic values. Human osteosarcoma cell lines Saos2 and HOS were transfected with the pcDNA-Ftx constructs. The scratch wound healing assay and Transwell assay were used to assess cell migration and invasion capability, respectively. Western blot analysis was conducted to investigate the expression of mesenchymal and epithelial markers. RESULTS The results showed that the lncRNA Ftx group was higher in osteosarcoma tissues compared with the ANCTs group. Expression of lncRNA Ftx was correlated with the clinical stage and distant metastasis (P<0.05). The overall survival rate was lower in the high lncRNA Ftx group than in the low lncRNA Ftx group (log-rank test, P<0.05). Multivariate analysis revealed that in osteosarcoma patients, higher lncRNA MEG3, advanced clinical stage, and distant metastasis were all independent predictors of overall survival. Cell research showed that transfection of lncRNA Ftx significantly promoted the migration and invasion ability of osteosarcoma cells. In addition, E-cadherin was decreased, while N-cadherin and Snail-1 were increased, at both the protein and mRNA levels. Pre-treatment with Snail-1 siRNA abrogated the promotion effect of Ftx on the migration and invasion of osteosarcoma cells. CONCLUSIONS Increased expression of lncRNA Ftx could not only be a biomarker for progression and prognosis of osteosarcoma, but also could regulate the development of osteosarcoma via the epithelial to mesenchymal transition (EMT) mechanism.