Miracle-dz/UniFAR-FTUs huggingface dataset:
Polymer Optical Fiber Sensors in Healthcare Applications: A Comprehensive Review

Advances in medicine and improvements in life quality has led to an increase in the life expectancy of the general population. An ageing world population have placed demands on the use of assistive technology and, in particular, towards novel healthcare devices and sensors. Besides the electromagnetic field immunity, polymer optical fiber (POF) sensors have additional advantages due to their material features such as high flexibility, lower Young’s modulus (enabling high sensitivity for mechanical parameters), higher elastic limits, and impact resistance. Such advantages are well-aligned with the instrumentation requirements of many healthcare devices and in movement analysis. Aiming at these advantages, this review paper presents the state-of-the-art developments of POF sensors for healthcare applications. A plethora of healthcare applications are discussed, which include movement analysis, physiological parameters monitoring, instrumented insoles, as well as instrumentation of healthcare robotic devices such as exoskeletons, smart walkers, actuators, prostheses, and orthosis. This review paper shows the feasibility of using POF sensors in healthcare applications and, due to the aforementioned advantages, it is possible to envisage a further widespread use of such sensors in this research field in the next few years.
A Function-Centered Taxonomy of Visual Attention

It is suggested that the relationship between visual attention and conscious visual experience can be simplified by distinguishing different aspects of both visual attention and visual experience. A set of principles is first proposed for any possible taxonomy of the processes involved in visual attention. A particular taxonomy is then put forward that describes five such processes, each with a distinct function and characteristic mode of operation. Based on these, three separate kinds—or possibly grades—of conscious visual experience can be distinguished, each associated with a particular combination of attentional processes.
Deep ECG-Respiration Network (DeepER Net) for Recognizing Mental Stress

Unmanaged long-term mental stress in the workplace can lead to serious health problems and reduced productivity. To prevent this, it is important to recognize and relieve mental stress in a timely manner. Here, we propose a novel stress detection algorithm based on end-to-end deep learning using multiple physiological signals, such as electrocardiogram (ECG) and respiration (RESP) signal. To mimic workplace stress in our experiments, we used Stroop and math tasks as stressors, with each stressor being followed by a relaxation task. Herein, we recruited 18 subjects and measured both ECG and RESP signals using Zephyr BioHarness 3.0. After five-fold cross validation, the proposed network performed well, with an average accuracy of 83.9%, an average F1 score of 0.81, and an average area under the receiver operating characteristic (ROC) curve (AUC) of 0.92, demonstrating its superiority over conventional machine learning models. Furthermore, by visualizing the activation of the trained network’s neurons, we found that they were activated by specific ECG and RESP patterns. In conclusion, we successfully validated the feasibility of end-to-end deep learning using multiple physiological signals for recognition of mental stress in the workplace. We believe that this is a promising approach that will help to improve the quality of life of people suffering from long-term work-related mental stress.
Changes in Content of Polyphenols and Ascorbic Acid in Leaves of White Cabbage after Pest Infestation

Crops, such as white cabbage (Brassica oleracea L. var. capitata (L.) f. alba), are often infested by herbivorous insects that consume the leaves directly or lay eggs with subsequent injury by caterpillars. The plants can produce various defensive metabolites or free radicals that repel the insects to avert further damage. To study the production and effects of these compounds, large white cabbage butterflies, Pieris brassicae and flea beetles, Phyllotreta nemorum, were captured in a cabbage field and applied to plants cultivated in the lab. After insect infestation, leaves were collected and UV/Vis spectrophotometry and HPLC used to determine the content of stress molecules (superoxide), primary metabolites (amino acids), and secondary metabolites (phenolic acids and flavonoids). The highest level of superoxide was measured in plants exposed to fifty flea beetles. These plants also manifested a higher content of phenylalanine, a substrate for the synthesis of phenolic compounds, and in activation of total phenolics and flavonoid production. The levels of specific phenolic acids and flavonoids had higher variability when the dominant increase was in the flavonoid, quercetin. The leaves after flea beetle attack also showed an increase in ascorbic acid which is an important nutrient of cabbage.
Analysis of the Effects of Day-Time vs. Night-Time Surgery on Renal Transplant Patient Outcomes

Sleep deprivation and disruption of the circadian rhythms could impair individual surgical performance and decision making. For this purpose, this study identified potential confounding factors on surgical renal transplant patient outcomes during day and night. Our retrospective cohort study of 215 adult renal cadaver transplant recipients, of which 132 recipients were allocated in the “day-time” group and 83 recipients in the “night-time” group, primarily stratified the patients into two cohorts, depending on the start time. Within a 24 h operational system, “day-time” was considered as being from 8 a.m. to 8 p.m. and “night-time” from 8 p.m. to 8 a.m. Primary outcomes examined patient and graft survival after three months and one year. Secondary outcomes included the presence of acute rejection (AR) and delayed graft function (DGF), as well as the rate of postoperative complications. In log-rank testing, “day-time” surgery was associated with a significantly higher risk of patient death (p = 0.003), whereas long-term graft survival was unaffected by the operative time of day. The mean cold ischemia time (CIT), which was 12.4 ± 5.3 h in the “night-time” group, was significantly longer compared to 10.7 ± 3.6 for those during the day (p = 0.01). We observed that “night-time” kidney recipients experienced more wound complications. From our single-centre data, we conclude that night-time kidney transplantation does not increase the risk of adverse events or predispose the patient to a worse outcome. Nevertheless, further research is required to explore the effect of fatigue on nocturnal surgical performance.
In-Depth Characterization of Bioactive Extracts from Posidonia oceanica Waste Biomass

Posidonia oceanica waste biomass has been valorised to produce extracts by means of different methodologies and their bioactive properties have been evaluated. Water-based extracts were produced using ultrasound-assisted and hot water methods and classified according to their ethanol-affinity (E1: ethanol soluble; E2: non-soluble). Moreover, a conventional protocol with organic solvents was applied, yielding E3 extracts. Compositional and structural characterization confirmed that while E1 and E3 extracts were mainly composed of minerals and lipids, respectively, E2 extracts were a mixture of minerals, proteins and carbohydrates. All the extracts showed remarkably high antioxidant capacity, which was not only related to phenolic compounds but also to the presence of proteins and polysaccharides. All E2 and E3 extracts inhibited the growth of several foodborne fungi, while only E3 extracts decreased substantially the infectivity of feline calicivirus and murine norovirus. These results show the potential of P. oceanica waste biomass for the production of bioactive extracts.
DNA Methylation Status in Cancer Disease: Modulations by Plant-Derived Natural Compounds and Dietary Interventions

The modulation of the activity of DNA methyltransferases (DNMTs) represents a crucial epigenetic mechanism affecting gene expressions or DNA repair mechanisms in the cells. Aberrant modifications in the function of DNMTs are a fundamental event and part of the pathogenesis of human cancer. Phytochemicals, which are biosynthesized in plants in the form of secondary metabolites, represent an important source of biomolecules with pleiotropic effects and thus provide a wide range of possible clinical applications. It is well documented that phytochemicals demonstrate significant anticancer properties, and in this regard, rapid development within preclinical research is encouraging. Phytochemicals affect several epigenetic molecular mechanisms, including DNA methylation patterns such as the hypermethylation of tumor-suppressor genes and the global hypomethylation of oncogenes, that are specific cellular signs of cancer development and progression. This review will focus on the latest achievements in using plant-derived compounds and plant-based diets targeting epigenetic regulators and modulators of gene transcription in preclinical and clinical research in order to generate novel anticancer drugs as sensitizers for conventional therapy or compounds suitable for the chemoprevention clinical setting in at-risk individuals. In conclusion, indisputable anticancer activities of dietary phytochemicals linked with proper regulation of DNA methylation status have been described. However, precisely designed and well-controlled clinical studies are needed to confirm their beneficial epigenetic effects after long-term consumption in humans.
Mathematical Modeling of Mucociliary Clearance: A Mini-Review

Mucociliary clearance is an important innate host defense of the mammalian respiratory system, as it traps foreign substances, including pollutants, pathogens, and allergens, and transports them out of the airway. The underlying mechanism of the actuation and coordination of cilia, the interplay between the cilia and mucus, and the formation of the metachronal wave have been explored extensively both experimentally and mathematically. In this mini-review, we provide a survey of the mathematical models of mucociliary clearance, from the motion of one single cilium to the emergence of the metachronal wave in a group of them, from the fundamental theoretical study to the state-of-the-art three-dimensional simulations. The mechanism of cilium actuation is discussed, together with the mathematical simplification and the implications or caveats of the results.
Symmetry, Structure, and Emergent Subsystems

Symmetries impose structure on the Hilbert space of a quantum mechanical model. The mathematical units of this structure are the irreducible representations of symmetry groups and I consider how they function as conceptual units of interpretation. For models with symmetry, the properties of irreducible representations constrain the possibilities of Hilbert space arithmetic, i.e.\ how a Hilbert space can be decomposed into sums of subspaces and factored into products of subspaces. Partitioning the Hilbert space is equivalent to parsing the system into subsystems, and these emergent subsystems provide insight into the kinematics, dynamics, and informatics of a quantum model. This article provides examples of how complex models can be built up from irreducible representations that correspond to `natural' ontological units like spins and particles. It also gives examples of the reverse process in which complex models are partitioned into subsystems that are selected by the representations of the symmetries and require no underlying ontological commitments. These techniques are applied to a few-body model in one-dimension with a Hamiltonian depending on an interaction strength parameter. As this parameter is tuned, the Hamiltonian runs dynamical spectrum from integrable to chaotic, and the subsystems relevant for analyzing and interpreting the dynamics shift accordingly.
Improving the Utility of Compiler Fuzzers

Aggressive random testing tools, or fuzzers, are impressively effective at finding bugs in compilers and programming language runtimes. For example, a single test-case generator has resulted in more than 460 bugs reported for a number of production-quality C compilers. However, fuzzers can be hard to use. The first problem is that failures triggered by random test cases can be difficult to debug because these tests are often large. To report a compiler bug, one must often construct a small test case that triggers the bug. The existing automated test-case reduction technique, delta debugging, is not sufficient to produce small, reportable test cases. A second problem is that fuzzers are indiscriminate: they repeatedly find bugs that may not be severe enough to fix right away. Third, fuzzers tend to generate a large number of test cases that only trigger a few bugs. Some bugs are triggered much more frequently than others, creating needle-in-the-haystack problems. Currently, users rule out undesirable test cases using ad hoc methods such as disallowing problematic features in tests and filtering test results. This dissertation investigates approaches to improving the utility of compiler fuzzers. Two components, an aggressive test-case reducer and a tamer, are added to the fuzzing workflow to make the fuzzer more user friendly. We introduce C-Reduce, an aggressive test-case reducer for C/C++ programs, which exploits rich domain-specific knowledge to output test cases nearly as good as those produced by skilled humans. This reducer produces outputs that are, on average, more than 30 times smaller than those produced by the existing reducer that is most commonly used by compiler engineers. Second, this dissertation formulates and addresses the fuzzer taming problem: given a potentially large number of random test cases that trigger failures, order them such that diverse, interesting test cases are highly ranked. Bug triage can be effectively automated, relying on techniques from machine learning to suppress duplicate bug-triggering test cases and test cases triggering known bugs. An evaluation shows the ability of this tool to solve the fuzzer taming problem for 3,799 test cases triggering 46 bugs in a C compiler. To my wife and my parents, for their unwavering love, support, and encouragement
LncRNA MEG3 inhibits cell proliferation and induces apoptosis in laryngeal cancer via miR‐23a/APAF‐1 axis

Long non‐coding RNA (LncRNA) MEG3 serves a regulatory role in the progression of several types of cancer, but the role of MEG3 in laryngeal cancer is still unknown. The aim of this study was to explore the regulatory role and mechanism of MEG3 in laryngeal cancer. MEG3 expression in 50 laryngeal cancer tissue samples was detected by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR). The effects of MEG3 overexpression on laryngeal cancer cells were investigated in vitro and in vivo. The mechanism of competitive endogenous RNA (ceRNA) was validated through luciferase reporter assay, RT‐qPCR and Western blotting. MEG3 was down‐regulated in laryngeal cancer tissues, and the low MEG3 expression was associated with advanced clinical stage. Additionally, MEG3 overexpression inhibited the proliferation and induced the apoptosis of laryngeal cancer cells in vitro and in vivo. Particularly, MEG3 bound to miR‐23a specifically and a reciprocal negative regulation existed between miR‐23a and MEG3. Moreover, MEG3 up‐regulated apoptotic protease activating factor‐1 (APAF‐1), a known miR‐23a's target, thereby leading to the activation of caspase‐9 and caspase‐3. Meanwhile, these activated effects were rescued by miR‐23a overexpression. In conclusion, the present study demonstrated that MEG3 functions as a novel tumour suppressive LncRNA in laryngeal cancer for the first time. Furthermore, MEG3 may act as a ceRNA to regulate APAF‐1 expression by competitive binding to miR‐23a, thereby regulating the progression of laryngeal cancer.
Author's Response

Sir, I am grateful to those who have offered a thoughtful commentary on my report of dismemberments carried out by a necrofetishist. It is true that H€akk€anen-Nyholm et al. (1) have proposed the concept of psychotic dismemberment; offenders who dismember whilst suffering from delusions borne of schizophrenia. However, to my knowledge, the concept has gained little traction. Indeed, in a recent review of 55 dismemberments in New York, more than four times the number of dismemberments examined by H€akk€anen-Nyholm et al. (1), the concept of psychotic dismemberment is not even mentioned (2). Whilst I do not reject the concept per se, I am minded to agree with P€uschel and Koops (3), and Konopka et al. (4) that psychotic dismemberment does not warrant a specific category of its own. The appeal of the current categorizations is their mutual exclusivity. Indeed, in the case I describe there was movement between categories, but not an overlap. Psychotic dismemberment confuses the simplicity of current categorizations by offering the opportunity for them to become blurred, can the psychotic offender not be aggressive or offensive in his actions? To offer a little clarification on some other points raised by my report, I would like to explain what the offender meant when he said “alcohol would decide who would be a victim. ” It was his modus operandi to lure men to his home and then reduce them to a weakened state, whereby he could more easily subdue them with an attack, by plying them with alcohol. He too would drink alcohol. On several occasions, he became so intoxicated he did not attack the men, or did so but failed to subdue them. Indeed, the police were called after men had successfully repelled his attack and visited his home whilst bodies lay underneath the floorboards. The trigger in the offender that progressed him from defensive mutilation to mutilation fuelled by hatred was the realization that the loneliness he endured would return when his dead “partners” left him; something he had not realized until after the first murder victim had been dispatched. I would also say that whilst I do not disagree with authors who assert that dismemberment can be sexually motivated, and I reiterate that in the case I present the offender was a necrofetishist, a very specific type of necrophile, in this instance there is no evidence to suggest such a motivation. The sexual element existed only until bodies showed outward signs of decay, when he viewed them as people with whom he shared a relationship; sex was a part of that relationship. Once decay and decomposition began the relationship ended, anger then replaced any sexual desire, anger that his “partners” had left him and he would once again be returned to loneliness.
Einstein’s quadrupole formula from the kinetic-conformal Hořava theory

We analyze the radiative and nonradiative linearized variables in a gravity theory within the family of the nonprojectable Hořava theories, the Hořava theory at the kinetic-conformal point. There is no extra mode in this formulation, the theory shares the same number of degrees of freedom with general relativity. The large-distance effective action, which is the one we consider, can be given in a generally-covariant form under asymptotically flat boundary conditions, the Einstein-aether theory under the condition of hypersurface orthogonality on the aether vector. In the linearized theory, we find that only the transverse-traceless tensorial modes obey a sourced wave equation, as in general relativity. The rest of variables are nonradiative. The result is gauge-independent at the level of the linearized theory. For the case of a weak source, we find that the leading mode in the far zone is exactly Einstein’s quadrupole formula of general relativity, if some coupling constants are properly identified. There are no monopoles nor dipoles in this formulation, in distinction to the nonprojectable Horava theory outside the kinetic-conformal point. We also discuss some constraints on the theory arising from the observational bounds on Lorentz-violating theories.
State of the Art of Natural Killer Cell Imaging: A Systematic Review

Natural killer (NK) cell therapy is a promising alternative to conventional T cell-based treatments, although there is a lack of diagnostic tools to predict and evaluate therapeutic outcomes. Molecular imaging can offer several approaches to non-invasively address this issue. In this study, we systematically reviewed the literature to evaluate the state of the art of NK cell imaging and its translational potential. PubMed and Scopus databases were searched for published articles on the imaging of NK cells in humans and preclinical models. Study quality was evaluated following Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) criteria. We pooled studies as follows: Optical, magnetic resonance imaging (MRI) and nuclear medicine imaging with a total of 21 studies (n = 5, n = 8 and n = 8, respectively). Considering the limitation of comparing different imaging modalities, it appears that optical imaging (OI) of NK cells is very useful in a preclinical setting, but has the least translational potential. MRI provides high quality images without ionizing radiations with lower sensitivity. Nuclear medicine is the only imaging technique that has been applied in humans (four papers), but results were not outstanding due to a limited number of enrolled patients. At present, no technique emerged as superior over the others and more standardization is required in conducting human and animal studies.
HIV pre‐exposure prophylaxis for adolescent girls and young women in Africa: from efficacy trials to delivery

Adolescent girls and young women (AGYW) in Africa have high HIV incidence despite scale‐up of HIV testing and HIV treatment. Placebo‐controlled trials of tenofovir‐based pre‐exposure prophylaxi (PrEP) in diverse populations demonstrated that PrEP works with close to 100% effectiveness if taken with high, but not perfect, adherence. Divergent efficacy estimates among African AGYW led to demonstration and implementation projects to better understand motivations for HIV prevention, uptake, adherence and persistence to PrEP. To inform PrEP programmes, the design and initial findings from PrEP demonstration projects for AGYW are reviewed.