Miracle-dz/UniFAR-FTUs huggingface dataset:
Sex does not influence impairments in popliteal endothelial-dependent vasodilator or vasoconstrictor responses following prolonged sitting.

An acute bout of prolonged sitting (PS) impairs the popliteal artery flow-mediated dilation (FMD) response. Despite equivocal reductions in mean shear rate, young women demonstrate an attenuated decline in popliteal FMD versus young men. However, it is uncertain whether popliteal endothelial-dependent vasoconstrictor responses [low-flow mediated constriction (L-FMC)] are similarly affected by PS and/or if sex differences exist. We tested the hypothesis that women would have attenuated reductions in both popliteal FMD and L-FMC responses following an acute bout of PS. Popliteal FMD, and L-FMC responses were assessed via duplex ultrasonography before and after a 3-hour bout of PS. These responses were then compared between 10 men (24±2 years) and 10 women (23±2 years) matched (P>0.13) for habitual levels of objectively measured physical activity (via PiezoRx) and sedentary time (via activPAL). At baseline, men and women exhibited similar (P>0.46) popliteal FMD (4.8±1.2% vs. 4.5±0.6%) and L-FMC (-1.7±1.0% vs. -1.9±0.9%) responses. Both sexes experienced identical (group: P>0.76; time: P<0.001) PS-induced impairments in popliteal FMD (-2.8±1.4% vs. -2.6±0.9%) and L-FMC (1.3±0.7% vs. 1.4±0.7%). In young adults, sex did not influence the negative PS-induced FMD, L-FMC or microvascular responses in the lower limb. As such, our findings suggest that young men and women are similarly susceptible to the acute negative vascular effects of PS. Future studies should extend these findings to older, less physically active adults and/or patients with vascular disease.
Early recovery of neuronal functioning in the sensory cortex after nerve reconstruction surgery

Background: Nerve reconstructive surgery induces a transient loss and a prolonged and a gradual return of sensory inputs to the brain. It is unknown whether, following this massive peripheral denervation, the brain will experience a prolonged period of severe, intrinsic dysfunction. Objective: We aim to investigate the mechanisms of return of processing function in cortical neurons. Methods: We used the whisker model in rats to evaluate the functional recovery in the somatosensory cortex after a nerve reconstruction surgery. Multi-unit recording in the barrel cortex was performed in lightly anesthetized rats while their whiskers were stimulated by a whisker stimulator. Results: We observed a loss of neuronal responses to whisker stimulation 1 week after surgery, which started to recover 2 weeks after surgery. Following the surgery, only 11.8% of units had principle whiskers (PWs) returned to their original status while 17.7% had PWs different from their original status, indicating the effect of aberrant reinnervation on the whisker response map. Conclusions: Robust neuronal responses to sensory stimulation even when only sparse sensory inputs are available in the early recovery phase. During this phase, aberrant reinnervation induces disorganized whisker tuning, a finding that might be account for the hypoesthesia and paresthesia during early recovery after nerve reconstruction.
Effects of fish caudal fin sweep angle and kinematics on thrust production during low-speed thunniform swimming

ABSTRACT Scombrid fish lunate caudal fins are characterized by a wide range of sweep angles. Scombrid that have small sweep-angle caudal fins move at higher swimming speeds, suggesting that smaller angles produce more thrust. Furthermore, scombrids occasionally use high angles of attack (AoA) suggesting this also has some thrust benefit. This work examined the hypothesis that a smaller sweep angle and higher AoA improved thrust in swimmers by experimentally analyzing a robophysical model. The robophysical model was tested in a water tunnel at speeds between 0.35 and 0.7 body lengths per second. Three swept caudal fins were analyzed at three different AoA, three different freestream velocities, and four different Strouhal numbers, for a total of 108 cases. Results demonstrated that the fin with the largest sweep angle of 50° resulted in lower thrust production than the 40° and 30° fins, especially at higher Strouhal numbers. Larger AoA up to 25° increased thrust production at the higher Strouhal numbers, but at lower Strouhal numbers, produced less thrust. Differences in thrust production due to fin sweep angle and AoA were attributed to the variation in spanwise flow and leading edge vortex dynamics. Summary: The study examines the impact of scombrid fish caudal fin sweep angle and angle of attack on thrust production across a range of Strouhal numbers using a robophysical model.
Dyslipidemia and Meibomian Gland Dysfunction: Utility of Lipidomics and Experimental Prospects with a Diet-Induced Obesity Mouse Model

Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease and loss of ocular surface homeostasis. Increasingly, several observational clinical studies suggest that dyslipidemia (elevated blood cholesterol, triglyceride or lipoprotein levels) can initiate the development of MGD. However, conclusive evidence is lacking, and an experimental approach using a suitable model is necessary to interrogate the relationship between dyslipidemia and MGD. This systematic review discusses current knowledge on the associations between dyslipidemia and MGD. We briefly introduce a diet-induced obesity model where mice develop dyslipidemia, which can serve as a potential tool for investigating the effects of dyslipidemia on the meibomian gland. Finally, the utility of lipidomics to examine the link between dyslipidemia and MGD is considered.
Neuroacanthocytosis: a case report of chorea-acanthocytosis.

Neuroacanthocytosis is a rare progressive neurodegenerative disease, including Chorea-acanthocytosis, McLeod syndrome, Huntington's disease-like 2, and pantothenate kinase-associated neurodegeneration, where Choreaacanthocytosis occupies the main entity of this disease group. Here, a classic case of Chorea-acanthocytosis is reported that exhibited gradually deteriorating abnormal movements of limbs and face, swallowing difficulty, and lip and cheek biting for the past two years. Peripheral blood smears revealed that 35% of the red blood cells were acanthocytes and electron microcopy scans clearly showed the morphology of acanthocytes. VPS13A gene sequencing found a heterozygous novel VPS13A gene mutation (c.80dupT). Brain magnetic resonance imaging scans showed moderate anterior horn dilation of lateral ventricles and bilateral atrophy of the head of caudate nucleus. Several suggestive features are summarized to provide diagnostic clues for Chorea-acanthocytosis and facilitate future diagnosis and treatment.
Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer

The antipsychotic drug pimozide has been found to exhibit anticancer effects. Previously, it was demonstrated that pimozide inhibits hepatocellular carcinoma (HCC) cell growth, but its pharmacodynamic characteristics remain unclear. The aim of the present study was to investigate the reversibility and mechanism of the ability of pimozide to inhibit cell proliferation in liver cancer. Cell viability was determined by Cell Counting Kit-8 and colony formation assay. The cell cycle distribution was analyzed by flow cytometry with Ki-67 and PI staining. ROS production of HCC cells was detected with DCFH-DA and inhibited with NAC treatment. Western blot assay was performed to detect the expression of related signaling molecules in HCC cells. Our results showed that pimozide promoted G0/G1 phase arrest in HCC cell lines without significant cell death. Its anti-proliferative effects on HCC cells were reversible, consistent with involvement of cell quiescence and reactive oxygen species (ROS) production. Pimozide enhanced inhibition of HCC cell proliferation by sorafenib. In conclusion, elucidation of pimozide's reversible proliferation inhibition in liver cancer and additive activity with a well-established anticancer drug warrants further exploration of the potential of pimozide as an adjuvant anticancer therapy.
Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies

Different diseases and disorders that affect the kidneys include, but are not limited to, glomerulonephritis, diabetic nephropathy, polycystic kidney disease, kidney stones, renal fibrosis, sepsis, and renal cell carcinoma. Kidney disease tends to develop over many years, making it difficult to identify until much later when kidney function is severely impaired and undergoing kidney failure. Although conservative care, symptom management, medication, dialysis, transplantation, and aggressive renal cancer therapy are some of the current strategies/approaches to kidney disease treatment, new preventative targeted therapies are needed. Epidemiological studies have suggested that a diet rich in fruits and vegetables is associated with health benefits including protection against kidney disease and renal cancer. Resveratrol, a polyphenol found in grapes and berries, has been reported to have antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, neuroprotective, and anti-cancer properties. The current review summarizes the existing in vitro and in vivo animal and human studies examining the nephroprotective effects of resveratrol.
Does Involuntary Neural Activation Increase Public Goods Contributions

In a laboratory experiment, we use a public goods game to examine the hypothesis that human subjects use an involuntary eye-detector mechanism for evaluating the level of privacy. Half of our subjects are "watched" by images of a robot presented on their computer screen. The robot—named Kismet and invented at MIT—is constructed from objects that are obviously not human with the exception of its eyes. In our experiment, Kismet produces a significant difference in behavior that is not consistent with existing economic models of preferences, either self- or other-regarding. Subjects who are "watched" by Kismet contribute 29% more to the public good than do subjects in the same setting without Kismet.
Grey Lungs and Blue Moods: Smoking Cessation in the Context of Lifetime Depression History

Objective: To present an overview of the relationship between depression and cigarette smoking and to provide recommendations for clinicians who wish to help patients with a history of depression to stop smoking. Method: English language journal articles published in the last 15 years on clinical material related to depression history, smoking cessation and related health issues were collected via MEDLINE, PsycINFO and Cochrane Library database searches. Results: Nicotine dependence is associated with increased rates of depression prior to and after taking up smoking as well as increased rates of suicidal ideation. Depression history is associated with increased rates of nicotine dependence, problems with smoking cessation and depression after cessation. While nicotine replacement and counselling are effective for smoking cessation, standard smoking cessation strategies may not pay sufficient attention to the needs of smokers with a depression history. Some antidepressants (bupropion and nortriptyline) are particularly effective for those with a lifetime depression history as they appear to assist with dysphoria during withdrawal and prevent relapse. Psychological and lifestyle strategies, such as motivational interviewing, relaxation exercises and mood charts, assist in mood regulation over and above the standard smoking cessation treatments for smokers with a depression history, who require more attention to relapse of depression and smoking after quitting. Conclusions: There is a complex and circular relationship between depression, smoking and medical illness that complicates smoking cessation in those who have a history of depression. Depression-history smokers require a multimodal approach to assist with mood regulation and nicotine withdrawal. Further research is required to identify effective strategies to reduce smoking in this context.
Right-wing authoritarianism, social dominance orientation, and prejudice

Right-wing authoritarianism and social dominance orientation have been proposed as 2 major individual-difference variables underlying prejudice. This study examined the relationships of these variables to 3 forms of prejudice-affective responses, stereotyping, and attitudes toward equality enhancement-directed at 2 social groups-African Americans and homosexuals. Canonical correlation analyses showed that social dominance orientation was related to most forms of prejudice directed toward both groups and that right-wing authoritarianism was related to affective responses to and stereotyping of homosexuals. In addition, it was found that, as predicted by the social dominance model, stereotyping mediated the relationships between social dominance orientation and other forms of prejudice and that social dominance orientation mediated gender differences in expressions of prejudice.
Attention in character-classification tasks: Evidence for the automaticity of component stages.

SUMMARY Most theories of attention predict that engaging a subject in demanding concurrent activity will increase choice reaction time by an amount proportional to the attention demands of the choice task. The attention demands of mental operations within the choice task can be assessed by extending Sternberg's additivefactors method. Parameters associated with those processing stages that demand attention will interact with the amount of concurrent activity (i.e., will have greater effects with concurrent activity than without), but parameters associated with automatic processing stages will not (i.e., the joint effects will be additive). This analysis was applied to eight character-classification experiments. The classification task was either performed alone or in the retention interval of a short-term memory task which required ordered recall of 7 digits. According to the extended additive-factors method, the important effects are the interactions of classification-task parameters with memory load. The first two experiments reported validate the method with a memory-search task. Interactions were obtained between memory load and target-set size whose magnitude depended on the amount of practice with specific target sets. Inferences about attention demand and automaticity were shown to be consistent with those drawn from another criterion for automaticity, based on a different aspect of the data. The remaining six experiments examined four stages sufficient to perform a visual-search task (encoding, comparison, decision, and response selection). Memory load did not interact with parameters associated with encoding, decision and response-selection stages, and of three parameters associated with the comparison stage (target-set size, array size, and the presence or absence of a bar marker indicating the target's position), only target-set size interacted with memory load (Experiments 1 and 2). It was concluded that most of the processing involved in character classification does not require attention, and this was taken as evidence against models that identify attention with specific processingstructures. The results were interpreted as supporting the view that attention is a limited capacity to activate processing structures internally, and the role of attention in preparing, maintaining, and executing mental operations is discussed.
Beyond the Pages of a Book: Interactive Book Reading and Language Development in Preschool Classrooms.

The effects of a book reading technique called interactive book reading on the language and literacy development of 4-year-olds from low-income families were evaluated. Teachers read books to children and reinforced the vocabulary in the books by presenting concrete objects that represented the words and by providing children with multiple opportunities to use the book-related words. The teachers also were trained to ask open-ended questions and to engage children in conversations about the book and activities. This provided children with opportunities to use language and learn vocabulary in a meaningful context. Children who were in the interactive book reading intervention group scored significantly better than children in the comparison group on Peabody Picture Vocabulary Test-III and other measures of receptive and expressive language. Book reading and related activities can promote the development of language and literacy skills in young children.
Von Neumann machine

The most influential paper in the history of computer science, whether or not anyone else expressed similar ideas earlier, was written in 1946 by John von Neumann, then on the staff of the Institute for Advanced Study at Princeton University, in collaboration with Arthur W. Burks and Herman H. Goldstine. Its title is "Preliminary Discussion of the Logical Design of an Electronic Computing Instrument," and the ideas it contains, collectively known as the von Neumann machine, have provided the foundation for essentially all computer system developments since that date.
Emergent Literacy in the Preschool Years

Recent surveys of national literacy standards have prompted a barrage of accusations that schools are not doing their job (e.g. Sydney Morning Herald, 16 Sept. 1997). It is widely accepted that children who have not made the breakthrough to literacy by the end of Year 2 are likely to have continuing problems. There is less agreement about when literacy starts. The Australian Language and Literacy Council (1995) states that what children bring to school is the critical factor in literacy, and neurological research indicates that the first three years of life are a critical learning period (Newberger, 1997). The purpose of this paper is to invite early childhood staff to review their programs to ensure that children are supported in their emergent literacy. Suggestions are made of ways in which staff can provide appropriate emergent literacy experiences and of the learning that can take place through these experiences.
Method of Avoiding the Speed Decay in Random Waypoint Mobility Model

The stabilization of the average nodal speed was critical to research some performances′ evaluation and analysis of Ad hoc networks by simulation. Random Waypoint Mobility Model suffers from speed decay—average nodal speed decreased until converging to some long-term average. Such decay is unsound for simulations that collect results averaged over time, complicating the experiments, and the assumption that steady-state lasts over all simulation makes the results unreliable, collected before average nodal speed arrives at real steady-state. This paper demonstrates via mathematical analysis that speed decay is in general inevitable deriving some conclusions, and then using them provides an improved model iRWP that can effectively avoid the speed decay.
MÜŞTERİ MEMNUNİYETİ TAHMİNİNDE YAPAY SİNİR AĞLARI, LOJİSTİK REGRESYON VE AYIRMA ANALİZİNİN PERFORMANSLARININ KARŞILAŞTIRILMASI

Bu calismada Musteri Memnuniyetinin tahmini icin Yapay Sinir Aglari, Lojistik Regresyon ve Ayirma Analizinin performanslari karsilastirilmistir. Veriler Usak’taki kamu hastanelerinde 2007 yilinda yapilan hasta memnuniyetini olcmeyi amaclayan bir anket uygulanarak elde edilmistir ve 364 hastayi kapsamaktadir. Sonuclar Yapay Sinir Aglarinin diger yontemlere gore musteri memnuniyetini daha iyi tahmin ettigini gostermistir
Data Mining Based on Privacy Preserving

The purpose of Privacy Preserving Data Mining(PPDM) is discovering accurate patterns and perfect results without precise access to the original data.The requirements of PPDM are put forward.Based on data hiding,PPDM methods are divided into three types:SMC,anonymization and data distortion,and they are evaluated under accuracy,privacy and complexity.
Stability of Rank 2 Ulrich Bundles on Projective K3 Surfaces

Let $F\subseteq\mathbb P ^{a+1}$ be a non-degenerate $K3$ surface of degree $2a$, where $a\ge2$. In this paper we deal with Ulrich bundles on $F$ of rank $2$. We deal with their stability and we construct $K3$ surfaces endowed with families of non-special Ulrich bundles of rank $2$ for each $a\ge2$.
A Literature Survey on Key Aggregate Cryptosystem for Multi File Data Sharing in Cloud

In cloud, data sharing plays an important role. This survey explains how to securely, efficiently and flexibly distribute the data with others in cloud. This survey depicts a key-aggregate or public key cryptosystem, which produces a constant size ciphertext such that efficient delegacy of ciphertext is possible. This new scheme can aggregate several set of secret keys into a solitary key and using this solitary key, multiple files can be decrypted and the files that are outside the ciphertext remain confidential. This aggregate key is stored in a smart card and can be shared with others in a safe channel.
THE GRAMMATICAL ACCURACY, COHESION AND COHERENCE OF THAI STUDENTS’ ENGLISH WRITING AT DARAWITHAYA SCHOOL, NARATHIWAT – THAILAND

Writing has been recognized as an important skill to be mastered by all students both English as Foreign Language (EFL) and English as Second Language (ESL) students since many universities around the world offer writing courses. Hence, this study attempts to analyze the grammatical accuracy, cohesion, and coherence of Thai Students’ English Writing at Darawithaya School. This study is designed to investigate (1) the grammatical accuracy on Students’ Writing, and (2) the cohesion and coherence on Students’ Writing. The participant of the study consists of 14 Second Grade Students of Senior High School who enroll Academic Education at Darawithaya School, Narathiwat – Thailand. Since this study is descriptive qualitative approach, the data is documentation from students’ writing work. Some guidelines and rubric are used in this research for analyzing. The findings reveal that there are 73 errors are found on 14 students’ composition in this study. They occur on singular/plural followed by subject omission, the use of article, pronoun, preposition, verb omission, S-V agreement, word formation, tense, and extraneous subject. Consequently, those errors make students’ grammatical accuracy value varied from one student to other students.
Vehicular Ad Hoc Networks

Vehicular Ad Hoc Network (VANET) is an emerging new technology integrating Ad Hoc network, cellular technology and wireless LAN (WLAN) to achieve vehicle to vehicle and vehicle to infrastructure communication for intelligent transportation systems (ITS). VANETs are distinguished from other kinds of Ad Hoc networks by node movement characteristics, their hybrid network architectures and new application scenarios. The vehicular network provides wide variety of services, ranging from safety-related warning systems to improved navigation mechanisms as well as information and entertainment applications. Therefore, VANETs pose many unique networking research challenges, and the design of efficient routing protocols that not only forward packets with good end to end delay but also take into consideration the reliability and progress in data packets forwarding. In this paper, we provide a review of VANETs architecture, its characteristics, applications various routing protocols and challenges.