Miracle-dz/UniFAR-FTUs huggingface dataset:
Technologies to enhance self-directed learning from hypertext

With the growing popularity of the World Wide Web, materials presented to learners in the form of hypertext have become a major instructional resource. Despite the potential of hypertext to facilitate access to learning materials, self-directed learning from hypertext is often associated with many concerns. Self-directed learners, due to their different viewpoints, may follow different navigation paths, and thus they will have different interactions with knowledge. Therefore, learners can end up being disoriented or cognitively-overloaded due to the potential gap between what they need and what actually exists on the Web. In addition, while a lot of research has gone into supporting the task of finding web resources, less attention has been paid to the task of supporting the interpretation of Web pages. The inability to interpret the content of pages leads learners to interrupt their current browsing activities to seek help from other human resources or explanatory learning materials. Such activity can weaken learner engagement and lower their motivation to learn. This thesis aims to promote self-directed learning from hypertext resources by proposing solutions to the above problems. It first presents Knowledge Puzzle, a tool that proposes a constructivist approach to learn from the Web. Its main contribution to Web-based learning is that self-directed learners will be able to adapt the path of instruction and the structure of hypertext to their way of thinking, regardless of how the Web content is delivered. This can effectively reduce the gap between what they need and what exists on the Web. SWLinker is another system proposed in this thesis with the aim of supporting the interpretation of Web pages using ontology based semantic annotation. It is an extension to the Internet Explorer Web browser that automatically creates a semantic layer of explanatory information and instructional guidance over Web pages. It also aims to break the conventional view of Web browsing as an individual activity by leveraging the notion of ontology-based collaborative browsing. Both of the tools presented in this thesis were evaluated by students within the context of particular learning tasks. The results show that they effectively fulfilled the intended goals by facilitating learning from hypertext without introducing high overheads in terms of usability or browsing efforts.
Association of the p 53 Codon 72 Polymorphism with Colorectal Cancer in South West of Iran

The p53 tumor suppressor gene plays two important roles in genomic stability: blocking cell proliferation after DNA damage until it has been repaired, and starting apoptosis if the damage is too critical. Codon 72 exon4 polymorphism (Arg72Pro) of the P53 gene has been implicated in cancer risk. Various studies have been done to investigate the status of p53 at codon 72 for arginine (Arg) and proline (Pro) alleles in different populations and also the association of this codon 72 polymorphism with various tumors. Our objective was to investigate the possible association between P53 Arg72Pro polymorphism and susceptibility to colorectal cancer among Isfahan and Chaharmahal Va Bakhtiari (a part of south west of Iran) population. We investigated the status of p53 at codon 72 for Arg/Arg, Arg/Pro and Pro/Pro allele polymorphisms in blood samples from 145 colorectal cancer patients and 140 controls by Nested-PCR of p53 exon 4 and digestion with BstUI restriction enzyme and the DNA fragments were then resolved by electrophoresis in 2% agarose gel. The Pro allele was 279 bp, while the Arg allele was restricted into two fragments of 160 and 119 bp. Among the 145 colorectal cancer cases 49 cases (33.79%) were homozygous for the Arg72 allele (Arg/Arg), 18 cases (12.41%) were homozygous for the Pro72 allele (Pro/Pro) and 78 cases (53.8%) found in heterozygous (Arg/Pro). In conclusion, it can be said that p53Arg/Arg genotype may be correlated with possible increased risk of this kind of cancers in south west of Iran. Keywords—TP53, Polymorphism, Colorectal Cancer, Iran
Unraveling the mechanisms of the vertebrate circadian clock: zebrafish may light the way

Most organisms display oscillations of approximately 24 hours in their physiology. In higher organisms, these circadian oscillations in biochemical and physiological processes ultimately control complex behavioral rhythms that allow an organism to thrive in its natural habitat. Daily and seasonal light cycles are mainly responsible for keeping the circadian system properly aligned with the environment. The molecular mechanisms responsible for the control of the circadian clock have been explored in a number of systems. Interestingly, the circadian oscillations that are responsive to environmental stimuli are present very early during development. This review focuses on the advantages of using the zebrafish to study the development of the vertebrate circadian system and light‐dependent signaling to the clock. BioEssays 24:419–426, 2002. © 2002 Wiley Periodicals, Inc.
Destination Memory for Emotional Information in Older Adults

Background/Study Context: Destination memory, remembering the destination of the information that one tells, shows significant age-related decline. In the present paper, the authors sought to determine whether destination memory can be improved in older adults using emotional stimuli. This aim was motivated by findings showing better context memory for emotional than for neutral information in older adults. Methods: Younger and older adults were asked to tell neutral facts to three types of faces: a neutral one, an emotionally positive one, and an emotionally negative one. On a later recognition test, participants were asked to associate each previously told fact with the face to whom it was told. Results: Destination memory performance was better for facts told to negative than to positive faces, and the latter memory was better than for neutral faces in older adults. Conclusion: Older adults seem to place higher emphasis on emotional material relative to neutral faces, showing better memory for the association between statements and emotional faces. Mohamad El Haj is now at SCALab UMR CNRS 9193- Université de Lille, France.
Development of resistance to chlorhexidine diacetate in Pseudomonas aeruginosa and the effect of a "residual" concentration.

Stable resistance in Pseudomonas aeruginosa NCIMB 10421 was obtained by step-wise exposure to gradually increasing concentrations of chlorhexidine diacetate (CHX). Repeated exposure to a proposed "residual" (sub-MIC) concentration of CHX also created stable resistance. Resistance was also developed by a single exposure to the "residual" concentration of CHX, but this was unstable. Similar experiments with Escherichia coli and CHX or cetylpyridinium chloride resulted in no significant increase in resistance. Antibiotic susceptibility profiles of the CHX-resistant P. aeruginosa cultures showed no cross-resistance, although some of the cultures were resistant to benzalkonium chloride.
The Effects of Chronic Conditions and Elderly Background on the Development of Elderly Mobility Function

This study aims to analyze the influence of chronic conditions and chronic diseases on elderly mobility function in Indonesia using the panel data of IFLS 3, IFLS 4, and IFLS 5. The sample is a balanced panel of elderly aged 60 and above in IFLS 5, who have completed retrospective information and can be traced back since IFLS 3. This study uses the random-effects ordered logistic models. The self-assessed health status, marital status, residence area, working status, body mass index, education, gender, and age are used as covariates. The results suggest that the elderly probability of experiencing limited mobility function is increasing with age; while chronic conditions and chronic diseases such as diabetes, heart disease, and stroke significantly affect the impairment of mobility function of the elderly in Indonesia. Other covariates also have significant effects on elderly mobility function, except for residence area and marital status variables. Keywords— Chronic Conditions, Chronic Diseases, Elderly, IFLS, Mobility Function, Panel Data, Random-effects ordered logistic models
The Prevalence of Foot Ulceration and its Correlates in Type 2 Diabetic Patients: a Population‐based Study

The prevalence of peripheral neuropathy, peripheral vascular disease, and foot ulceration in Type 2 diabetic patients in the community were determined in a community‐based study. Eight hundred and eleven subjects (404 male, 407 female, mean age 65.4 (range 34–90) years, diabetes duration 7.4 (0–50) years) from 37 general practices in three UK cities were studied. Neuropathy was diagnosed clinically using modified neuropathy disability scores which were ascertained using structured interviews and clinical examinations by one observer in each city. Peripheral vascular disease was diagnosed if a history of revascularization was present or ≥ 2 foot pulses were absent. History of current or previous foot ulceration was recorded. The prevalence of neuropathy was 41.6% (95% confidence limits 38.3–44.9%) and the prevalence of PVD, 11% (9.1–13.7%). Forty‐eight percent of neuropathic patients reported significant neuropathic symptoms. Forty‐three patients (5.3% (3.8‐6.8%)) had current or past foot ulcers; 20 of these were pure neuropathic ulcers, 13 neuroischaemic, 5 pure vascular, and 5 were unclassified. Multiple logistic regression showed history of amputation, neuropathy disability score, and peripheral vascular disease to be significantly associated with foot ulceration after adjusting for age and diabetes duration. A substantial proportion of Type 2 diabetic patients, often elderly patients who do not attend hospitals, suffered from peripheral neuropathy and peripheral vascular disease. These patients are at risk of foot ulceration and may benefit from preventive footcare.
An Improved Activity Recognition Method Based on Smart Watch Data

Activity recognition is mainly used in health care, authentication and many other fields. Activity recognition based on a smart watch usually performs much better than any other means of activity recognition in these areas. With its small size, high integration and multi-function, smart watch holds more advantages over the devices used in image based activity recognition, for example, a monitor, which is usually location fixed and view limited. In this paper, we collected data of five behaviors, i.e. stand, walk, run, upstairs, downstairs from the accelerometer on a smart watch. These data are classified with CART decision tree. Experimental results prove that the proposed method improves the accuracy of activity recognition.
Computer Aided Polyp Detection with Texture Analysis

We present a novel pipeline for computer-aided detection (CAD) of colonic polyps by integrating texture analysis with volume rendering and conformal colon flattening. Using our method, the 3D polyp automatic detection problem is converted into a 2D image analysis problem. The colon surface is first segmented and extracted from the CT data set of the abdomen, which is then mapped to a 2D rectangle using conformal mapping. This flattened colon is rendered using a direct volume rendering technique with a translucent electronic biopsy transfer function. The polyps are detected by a 2D clustering method on the flattened image. The false positives are further reduced by analyzing the volumetric shape features of suspicious regions. Compared with shape based methods, our method is more efficient without the need of computing curvature and other shape parameters for the whole colon wall.
The Economic Impact of Relationship Bonding Tactics: A Research Agenda

The shifting of the transactional marketing paradigm into relational marketing has been paid more attention, particularly concerning the need to trace what the relational dimensions are that can bring superior financial performance. The research on relational marketing that focuses on relation quality is one area of research that is being developed from the relational marketing perspective.Nevertheless, there are still few research projects that give a complete explanation of the impact of the relational quality (satisfaction, trust, commitment) on the company's financial performance. Therefore, we need to explore and scrutinize the financial impact with respect to the relational quality of the company-customer relationship. The relational quality of the company-customer relationship is influenced by various customer-attracting tactics, which eventually have the potential to create a behaviour (the length of the relationship, cross purchase, up-grade, customer asset management (CUSAM)), as well as influencing a customer's attitude (positive word of mouth (WOM), price insensitivity, a tendency to not move away to another company). This conceptual p33 aper is intended to retrace the financial impact (return on investment (ROI)) and the stakeholder's value (Tobin's Q) from the relationship bonding tactics with respect to the relationship quality and CUSAM through the development of a conceptual framework that is able to explain the phenomenon.
Mitochondrial Changes in Adenocarcinoma of the Pancreas

Abstract The aim of our study was to analyse the mitochondrial ultrastructure in primary ductal adenocarcinomas of the pancreas and to compare it with normal pancreatic cells. 52 samples of adenocarcinoma of the pancreas obtained by surgical resection or by endosonographic biopsy were examined. Compared to normal mitochondrial ultrastructure in non-tumorous cells, the mitochondria in cancer cells had a dense matrix and condensed configuration or with lucent-swelling matrix associated with disarrangement and distortion of cristae and partial or total cristolysis. Functionally, these structural alterations presume the presence of hypoxia-tolerant and hypoxia-sensitive cancer cells.
Competency Based Curriculum Development Model of Operations Managers in Indonesian Logistics Industry

Indonesia’s robust economic growth after struggling from financial crisis during last decade is having a progressive effect on its logistics industry. But, the deficiency of competency development programs and training for operations managers in this sector generates a static improvement if compared to the other nations. Calibrating competencies and skills of operations manager in this industry along its education curriculum is critical to make a standpoint in Indonesian economy. This study is outlined to fill the gap of competencies’ necessity in this area and try to formulate the adaptive approach and understanding. Engaging an intensive literature review and collaborated with the analytic hierarchy process (AHP), this study identified several critical competencies that need to strengthen to establish national competency standard that could be employed for training and education curriculum development.
The stability of exponential backoff protocols for Slotted-Aloha with saturated queues

The Slotted-Aloha protocol has been widely studied in the past forty-five years. Nonetheless, when the Exponential Backoff (EB) is used to stabilize its behavior, the characterization of stability conditions have eluded all efforts. Here we prove that the EB with geometric law i ↦ b<sup>−i−i</sup><inf>0</inf>, with queues in saturation, is ergodic if and only if b > 1 and the initial offset is i<inf>0</inf> > 1, for any number of users. If i<inf>0</inf> = 0 the system is transient, and null recurrent for 0 < i<inf>0</inf> ≤ 1, where some intermediate behavior is possible, since not all backoff indexes are unstable.
Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans

Endogenous circadian clocks are robust regulators of physiology and behavior. Synchronization or entrainment of biological clocks to environmental time is adaptive and important for physiological homeostasis and for the proper timing of species-specific behaviors. We studied subjects in the laboratory for up to 55 days each to determine the ability to entrain the human clock to a weak circadian synchronizing stimulus [scheduled activity–rest cycle in very dim (≈1.5 lux in the angle of gaze) light–dark cycle] at three ≈24-h periods: 23.5, 24.0, and 24.6 h. These studies allowed us to test two competing hypotheses as to whether the period of the human circadian pacemaker is near to or much longer than 24 h. We report here that imposition of a sleep–wake schedule with exposure to the equivalent of candlelight during wakefulness and darkness during sleep is usually sufficient to maintain circadian entrainment to the 24-h day but not to a 23.5- or 24.6-h day. Our results demonstrate functionally that, in normally entrained sighted adults, the average intrinsic circadian period of the human biological clock is very close to 24 h. Either exposure to very dim light and/or the scheduled sleep–wake cycle itself can entrain this near-24-h intrinsic period of the human circadian pacemaker to the 24-h day.
Definition 2 ( Constrained Frequent Itemset Mining ) A constraint on itemsets is a function C : 2

The constraint-based pattern discovery paradigm was introduced with the aim of providing to the user a tool to drive the discovery process towards potentially interesting patterns, with the positive side effect of achieving a more efficient computation. In this paper we review and extend the state-of-the-art of the constraints that can be pushed in a frequent pattern computation. We introduce novel data reduction techniques which are able to exploit convertible anti-monotone constraints (e.g., constraints on average or median) as well as tougher constraints (e.g., constraints on variance or standard deviation). A thorough experimental study is performed and it confirms that our framework outperforms previous algorithms for convertible constraints, and exploit the tougher ones with the same effectiveness. Finally, we highlight that the main advantage of our approach, i.e., pushing constraints by means of data reduction in a level-wise framework, is that different properties of different constraints can be exploited all together, and the total benefit is always greater than the sum of the individual benefits. This consideration leads to the definition of a general Apriori-like algorithm which is able to exploit all possible kinds of constraints studied so far.
Periodontal regeneration of an intrabony osseous defect with combination of platelet rich fibrin and bovine derived demineralized bone matrix: A case report

Background: The ultimate goal of periodontal therapy is regeneration of tissues destroyed by periodontal disease. Previously, various bone graft materials have been tried for management of osseous defects resulting from the disease process. However, the trend has now shifted towards application of endogenous regenerative therapy. The recent introduction of Choukroun’s Platelet Rich Fibrin (PRF), has revolutionalized the field of dentistry. PRF, a rich source of autologous growth factors and cytokines, is an upcoming therapeutic approach in the management of periodontal osseous defects. Combination of autologous PRF and the otherwise commercially available bone grafts holds a promising potential of enhanced bone regeneration. Aim: The aim of this case report is to present the management of an intrabony osseous defect with combination of Platelet Rich Fibrin & Bovine derived demineralised bone matrix with clinical and radiographic evaluations for a 6 months follow up period. Material and Methods: A 40 year old female patient presented with the chief complaint of pain in relation to #13. Clinical evaluation revealed probing pocket depth (PPD) of 10mm and clinical attachment level (CAL) of 11mm distal to #13. Digital Radiographic analysis revealed angular bone loss in the region. Surgical therapy involved management by means of open flap debridement and placement of combination of autologous PRF and demineralized bone matrix in the combined wall defect. PRF was also used as membrane to secure the defect. Result: Post-operative evaluations revealed significant reduction in PPD and CAL gain at the end of 6 months. Also radiographic evidence of bone formation was observed as early as 3 months with almost complete fill by 6 months post-operatively. Conclusion: The combination therapy using platelet rich fibrin with demineralised bone matrix poses to be a rapid, effective and promising grafting modality for the management of intrabony osseous defects.
Challenges of Natural Resources Conservation Management in Mekit Ecotourism Sites, Ethiopia

This study tried to investigate major challenges of natural resources conservation management in Mekit from local governments, local communities, community project managers, culture and tourism office experts. A total of 188 purposively and systematically selected respondents using simple random and snowball sampling technique to gather quantitative and qualitative data. Both primary and secondary data were collected through semi-structured interviews, questionnaires, FGD and documents. Quantitative data were analyzed using descriptive statistical analysis with the help of SPSS version 22 to investigate major challenges of natural resources conservation management. Regardless of Mekit is rich with a variety of natural resources; it has been highly challenged due to agricultural land expansion, deforestation and population expansion. Mean and standard deviation values of respondents showed that ecotourism site of Mekit has been still affected by illegal hunting, local communities have no sense of ownership, free grazing, human wildlife conflict, land ownership problems, involuntary evacuation of local communities from their site, less government participation, poor collaboration and coordination among stakeholders. Thus, all relevant stakeholders shall capitalize on natural resources conservation initiatives whilst strongly working on challenges of natural resources conservation management to encourage sustainable livelihoods development of Mekit in particular and Ethiopia in general.
Sudden Infant Death Syndrome During Weekends and Holidays in Norway in 1967-1985

A few previous studies have revealed an increased risk for sudden infant death syndrome (SIDS) during weekends and holidays suggesting environmental factors as potential trigger mechanisms for death. In the present study, the weekend/holiday effect has been assessed on the basis of 1480 SIDS cases in 19 Norwegian counties during a 19-year period (1967-85). The phenomenon has been confirmed for 17 of the 19 counties. Special attention has been attached to differences in the geographical and seasonal distribution of the phenomenon. Deaths of other causes in infancy did not display such a dependency on the day of the week.
Ureaplasma diversum in bull semen in Australia: its detection and potential effects.

BACKGROUND The primary objective of this study was to confirm the infection status of Ureaplasma diversum in Australian bulls and to identify morphological changes of sperm from U. diversum-positive bulls. METHODS Fresh semen samples were taken from 29 sexually active beef bulls from suspect herds in the Riverina/Upper Murray region. U. diversum was identified using PCR analyses and culture of the organism. RESULTS Nine of the bulls were PCR-positive for U. diversum but none of these had genital lesions. Sperm from infected bulls showed increased incidence of abnormal tails (bent and coiled), as well as surface abnormalities (i.e. small protuberances or lumps). CONCLUSIONS The results suggest impairment of sperm function and possibly fertility. Further investigations into the potential role of U. diversum as a pathogen for Australian cattle are warranted.