Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanisms of activation of the leukocyte integrin LFA-1

This work was undertaken to characterise the interaction of the leukocyterestricted integrin LFA-1 (CD1la/CD18) with its ligands. LFA-1 function is critical for an immune response and, for example, allows leukocyte binding and transmigration across the endothelium, antigen presentation and cytotoxic T lymphocyte-mediated killing. The ligands for LFA-1 are the Intercellular Adhesion Molecules (ICAMs), with ICAM-1, ICAM-2 and ICAM-3 being the best characterised. The binding sites on ICAM-1 and ICAM-3 for LFA-1 were investigated with the use of antibodies and mutated proteins. The following regions were found to have a role in binding LFA-1: the CFG face of ICAM-3 domain 1; domain 2 of ICAM-1; a residue in domain 1 of ICAM-1 that is mutated at high frequency in African populations and is associated with susceptibility to cerebral malaria. Binding of Mg2+ or Mn2+ to the extracellular region of LFA-1 and intracellular signalling can both stimulate LFA-1 to adhere to ICAM-1, but by different processes. The former mechanism induces a high affinity form of LFA-1, which was shown to be achieved by an inter-domain movement involving the I domain of the LFA-1 α subunit. This is the first physical evidence for a conformational change occurring in an integrin upon activation. The mechanism by which intracellular signalling activates LFA-1 was demonstrated to involve calpaindependent clustering of LFA-1 in the membrane, thus increasing the avidity of LFA-1 for ICAM-1. Leukocyte Adhesion Deficiency-1 and Glanzmann's Thrombasthenia are genetic disorders in which mutations in the integrin genes result in absence of expression or expression of a non-functional integrin. The defects in function of leukocytes from a patient with clinical features of both disorders were studied. The results suggest that the patient has a novel form of integrin dysfunction in which integrins are expressed at normal levels, can be induced to bind their ligands by mechanisms which increase the affinity of interaction, but cannot be stimulated to bind ligand by intracellular signalling pathways.
Retención y desgaste de tres sistemas de "attachment" para prótesis totales mandibulares sobre implantes - Estudio in Vitro

Las sobredentaduras mandibulares retenidas por dos implantes son reconocidas como la primera opcion de tratamiento para pacientes edentulos, tal como recoge la Universidad McGill (Canada) en su declaracion de consenso publicada en 2002 y la sociedad britanica para el estudio de la odontologia protesica, en su declaracion de consenso de York, publicada en 2009. Al compararlas con protesis completas convencionales, proporcionan una mayor satisfaccion del paciente, una mayor capacidad masticatoria y una preservacion de altura de la cresta residual. El objetivo de este trabajo es evaluar la durabilidad y capacidad de retencion de attachments a largo del tiempo en inclinacion de 0°, 10° e 20° y en saliva artificial a 37°C. El diseno experimental tomo en cuenta la existencia de 3 tipos distintos de sistemas de attachments (Clix®: Preat Corporation, Santa Ynez, CA, United States; Dalbo-Plus®: Cendres+ Metaux, Biel/Bienne, Suiza; Locator®: Zest Anchors,Inc ,Escondido, United States), 3 inclinaciones diferentes y uno tipo de saliva artificial ( pH 7). Los 72 attachments fueron testados en una maquina de ensayo de fatiga durante 5400 ciclos (cinco anos) y se registraron los valores de retencion en ocho momentos diferentes (inicio, un mes, seis meses, un ano, dos anos, tres anos, cuatro anos, cinco anos). El analisis de los resultados demostro que la media de retencion (insercion y desinsercion) de los attachments fue siempre mayor en inclinacion de 0° do que en inclinacion de 20°. Todos los attachments del estudio han perdido valor maximo de retencion. La inclinacion influye en el valor de la fuerza intrinseca de cada attachment y tiene influencia en su durabilidad a lo largo del tiempo.
A Novel Cross-Layering Power Control Mechanism for AODV

Wireless networks are technologies with a growing interest in the area of telecommunications, such as the case of MANETs. Despite its advantages, MANETs present several challenges in the transmission of information due to the limited bandwidth, high error rate, energy consumption restriction, and variable topologies. The transmission power can significantly influence some of the aforementioned issues. This paper proposes Density Power Control Mechanism (DPCM), which employs a cross-layering approach between AODV (Ad-hoc On-Demand Distance Vector) routing protocol and the physical layer to adapt power transmission. DPCM aims to reduce collisions, maintain or improve the performance of AODV as well as to save power in the nodes. Our results indicate that our proposal can improve the performance of the network and save power at the same time. Moreover, it is especially useful for low- and medium-density scenarios.
Extending the Goals-Based Framework to Comprise Both Investment and Financial Planning

This article seeks to fill a void in the literature on goals-based planning. Most of the current work covers cases where clients already possess significant financial assets that they plan on totally or partially spending down, through expenses as well as various dynastic or philanthropic transfers. Yet, planners—be they focused on income/savings/expense management issues or conduct their work in the asset management sphere—have to deal with at least two other potential cases. Our analysis suggests that the goals-based planning approach has the potential to inject more texture into conversations with all clients. It also shows that there are significant, and at times even dramatic, differences in the ways one might deal with (1) an individual who is already wealthy and spending down his or her wealth, (2) another who may be wealthy but has unrealized nonfinancial wealth and ongoing current savings inflows, and (3) yet another who has a significant income and savings power but not enough accumulated financial wealth to live on. This is nothing more than the classical case of the difference between human and financial capital. Individuals in an asset decumulation mode have more financial than human capital, while those who are in an accumulation mode have more human than financial capital. As one might expect, this describes a full spectrum, and our “accumulation/decumulation case” falls somewhere between these extremes. TOPIC: Wealth management Key Findings • Goals-based wealth planning is the discipline most likely to help individuals and families achieve their goals, over the desired time horizons and with the desired sense of urgency or required probability of success and combines elements of both investment and financial planning. • There are three different personal finance scenarios that must be considered, rather than the sole wealth decumulation case usually considered. People still accumulating wealth also need help, whether they already have meaningful financial savings or are only starting to build them. • Though each scenario requires some change to the well-documented asset decumulation approach, they all benefit from the fact that discount rates used to evaluate future goals are both time-horizon and required-success-probability adjusted. • This approach may allow the creation of a completely new fee paradigm where advisory fees are based not on assets under advice but on measured progress toward the client’s goals.
Building capacity for dissemination and implementation to maximize research impact in a CTSA: The University of Wisconsin story

Abstract We report results of an 8-year process of stakeholder engagement aimed at building capacity in Dissemination and Implementation (D&I) research at the University of Wisconsin as part of the National Institutes of Health’s Clinical and Translational Science Award (CTSA). Starting in 2008, annual individual interviews were held with leaders of the Wisconsin CTSA’s community engagement core for strategic planning purposes. Interviews were followed by annual planning meetings that employed a facilitated group decision-making process aimed at identifying and prioritizing gaps in the translational research spectrum. In 2011, the stakeholder engagement process identified D&I as a primary gap limiting overall impact of the institution’s research across the translational spectrum. Since that time, our CTSA has created an array of D&I resources falling into four broad categories: (1) relationship building with D&I partners, (2) D&I skill building, (3) translational research resources, and (4) resources to support D&I activities. Our systematic process of stakeholder engagement has increased the impact of research by providing D&I resources to meet investigator and community needs. CTSAs could engage with leaders of their community engagement cores, which are common to all CTSAs, to adapt or adopt these resources to build D&I capacity.
Seismic-Resilient Electric Power Distribution Systems: Harnessing the Mobility of Power Sources

Mobile power sources (MPSs), including mobile emergency generators, truck-mounted mobile energy storage systems, and electric vehicles, have great potentials to be employed as grid-support resources during power grid emergency operating conditions to supply the critical loads and enhance the resilience of distribution system (DS) via a swift disaster restoration. We here investigate the MPS dispatch (i.e., routing and scheduling) in coordination with DS dynamic network reconfiguration. We propose a two-stage restoration scheme to facilitate the DS restoration following the high-impact low-probability (HILP) seismic disasters. In the first stage, a seismic hazard is simulated through a Monte Carlo simulation engine to estimate the unavailability of power distribution branches under a suite of seismic force scenarios. In the second stage, a mixed-integer nonlinear programming (MINLP) optimization model is formulated for DS restoration that cooptimizes the routing and scheduling of MPSs and DS dynamic network reconfiguration. The MINLP model is then linearized to a mixed-integer linear programming model to reduce the computation complexity, where the seismic-resilience recovery strategies are generated at different timescales. The efficacy of the proposed method is evaluated on the IEEE 33-node test system and the results verify a significant reduction in the load outages and an improved power system resilience to HILP earthquakes.
Attacks Toward Wireless Network-on-Chip and Countermeasures

A Wireless Network-on-Chip (WiNoC) offers a promising solution to reduce broadcast and long distance communication bottlenecks of conventional architectures by augmenting them with single hop wireless links. In this article, we discuss new security vulnerabilities and countermeasures to protect against them in a WiNoC based system. In particular, we describe Malicious Threshold Configuration (MTC) Attack, Disruptive Token Passing (DTP) Attack, Data Stealing by Broadcast (DSB) Attack and Hybrid Attack against the WiNoC. Our proposed countermeasure against MTC-OU (over-utilization) attack i.e., Source Destination checking mechanism decreases wireless hub utilization by 49% and network latency by many orders of magnitude compared to without countermeasure, causing system performance improvement. Another proposed countermeasure against DTP attacks i.e., detour mechanism improves the network throughout by 1.21x and 23x under DTP-AHT and DTP-DOS attacks respectively.
A Review Study on Educational Interventions Promoting Sexual Health of Children Under 12 Years

Context: Most children do not receive sexual education. This ignorance may adversely affect different dimensions of one’s sexual health. However, talking to children about this issue constantly but briefly can have positive impacts on their relationships and sexual health. This study aimed at reviewing different types of educational interventions related to the sexual health of children under 12 years.
Repurposing of Tamoxifen Against the Oral Bacteria.

Objectives Tamoxifen (TAM), which is used for treating breast cancer, has exhibited another important function as an antimicrobial agent. The objective of this study is to investigate the antibacterial action of TAM against the bacteria present in the human oral cavity. Materials and Methods The bacteria present in the human oral cavity were isolated from healthy individuals. Different concentrations of TAM were tested against the isolated bacteria. Additionally, bactericidal and bacteriostatic effects of TAM were also determined. Results Out of 23 isolated bacteria, a greater number of Gram-positive bacteria were highly susceptible to the low concentrations of TAM than Gram-negative bacteria. Kytococcus sedentarius, which is Gram-positive bacterium, and Pseudomonas stutzeri, which is Gram-negative bacterium, needed a high minimum inhibitory concentration value of TAM (2.5 mg/mL) to be inhibited by TAM's bacteriostatic action. Resistance to TAM was also observed in three strains of Gram-positive and four strains of Gram-negative bacteria. Conclusion TAM has shown a potential antibacterial effect against the bacteria present in the oral cavity, especially against Gram-positive bacteria. This effect is mostly bacteriostatic. This study also found bacterial resistance toward TAM.
Optimizing Interval Training Through Power-Output Variation Within the Work Intervals.

PURPOSE Maximal oxygen uptake (V˙O2max) is a key determinant of endurance performance. Therefore, devising high-intensity interval training (HIIT) that maximizes stress of the oxygen-transport and -utilization systems may be important to stimulate further adaptation in athletes. The authors compared physiological and perceptual responses elicited by work intervals matched for duration and mean power output but differing in power-output distribution. METHODS Fourteen cyclists (V˙O2max 69.2 [6.6] mL·kg-1·min-1) completed 3 laboratory visits for a performance assessment and 2 HIIT sessions using either varied-intensity or constant-intensity work intervals. RESULTS Cyclists spent more time at >90%V˙O2max during HIIT with varied-intensity work intervals (410 [207] vs 286 [162] s, P = .02), but there were no differences between sessions in heart-rate- or perceptual-based training-load metrics (all P ≥ .1). When considering individual work intervals, minute ventilation (V˙E) was higher in the varied-intensity mode (F = 8.42, P = .01), but not respiratory frequency, tidal volume, blood lactate concentration [La], ratings of perceived exertion, or cadence (all F ≤ 3.50, ≥ .08). Absolute changes (Δ) between HIIT sessions were calculated per work interval, and Δ total oxygen uptake was moderately associated with ΔV˙E (r = .36, P = .002). CONCLUSIONS In comparison with an HIIT session with constant-intensity work intervals, well-trained cyclists sustain higher fractions of V˙O2max when work intervals involved power-output variations. This effect is partially mediated by an increased oxygen cost of hyperpnea and not associated with a higher [La], perceived exertion, or training-load metrics.
ESPAÇOS LIVRES DE USO PÚBLICO NA PREVENÇÃO DO CRIME: UM ESTUDO SOBRE A REGIONAL 3 DE VILA VELHA - ES

The quality of urban life is directly linked to the development of social interaction and well-being, often promoted by the development of open spaces and its relation with green areas, directly influencing the physical and mental health of its users. The study starts from the analysis about the valuation of free spaces for public use and how these spaces can help in crime prevention. In this sense, the objective of this work was to survey the free spaces for public use and to understand how these spaces can aid in crime prevention in the municipality of Vila Velha ES. For this purpose, it was considered exclusively the area of Grande Aribiri (Regional 3), in order to identify and quantify these areas and their relation with the city. As a result, it was possible to identify that only 30% of the population of the whole Region is benefited with areas free of public use, so these areas do not serve the neighborhoods of the Region homogeneously.
The p Factor and the n Factor: Associations Between the General Factors of Psychopathology and Neuroticism in Children

Research across age groups has consistently indicated that psychopathology has a general factor structure such that a broad latent dimension (or p factor) captures variance common to all mental disorders as well as specific internalizing and externalizing factors. This research has found that the p factor overlaps substantially with trait negative emotionality (or neuroticism). However, less is known about the psychological substance of the specific factors of the general psychopathology model or how lower-order facets of neuroticism may relate to each psychopathology factor. We investigated the structure of neuroticism and psychopathology as well as associations between these domains using multimethod assessments in a sample of 695 preadolescent children. We found that both psychopathology and neuroticism may be well characterized by bifactor models and that there was substantial overlap between psychopathology (p) and neuroticism (n) general factors as well as between specific factors (Internalizing with Fear, Externalizing with Irritability).
Estimation of serum immunoglobulin E (IgE) level in allergic asthma andallergic rhinitis patients before and after treatment

Estimation of serum immunoglobulin E (IgE) level is a valuable diagnostic parameter in Allergic Asthma and allergic rhinitis[1,2]. This project work was done in collaboration with Dr. K. Sivanandhan who has been doing this research work for the last 20 years and has also established that Allergic Asthma and Allergic Rhinitis are curable diseases. Immunoglobulin ‘E’ (IgE) antibody has only been found in mammals and is associated with type I hypersensitivity reaction, where Immunoglobulin E level is found to be raised in a topic individuals and in some parasitic infestation like Schistsomiasis, Plasmodium falciparum etc… Atopic individuals (people who suffer from the Ig E mediated Allergies) can have upto 10 times the normal level of Ig E in their blood. In our study we took up 61 patients for IgE estimation both before and after treatment. The patients were treated by Dr. Sivanandhan with histaglobulin and other drugs. The Patients were from urban and rural areas comprising both male and females of all age groups. Out of 61 patients, 55 patients showed reduction in IgE Level (90.2%) and 6 patients showed no reduction in IgE level (9.8%) Clinically also, those patients with reduction in IgE level showed clinical improvement and these who did not have the reduction in IgE level also showed no clinical improvement. Among 61 patients 5 Patients showed 80% reduction in IgE level. 11 Patients showed 50- 80% reduction and 30 patients showed about 15-49% of reduction and 9 patients showed with 15% reduction IgE level after treatment. Hence, it is well established that the estimation of serum IgE level is a debendable laboratory data in patients suffering from allergic Asthma and allergic rhinitis.
Complicated measles in an 8-month old infant – a case report

Objective – To present a case of measles complicated by laryngotracheobronchitis and severe respiratory distress, and to emphasize the importance of vaccination. Case report – The authors report the case of an 8-month-old infant with fever, rash and wheezing. The diagnosis of measles complicated by laryngotracheobronchitis was made. The infant was admitted to the paediatric intensive care unit with severe respiratory distress, and required support with mechanical ventilation. The patient recovered fully. No nosocomial measles infections were identified. Conclusion – This case highlights the need for rapid diagnosis, appropriate treatment and determination of vaccination status of children with measles, in order to prevent complications.
Mixed-modality engagement assessment with biometrics

Getting feedback from users is the fundamental way for game designers to obtain insight for their game. However, the traditional methods of getting feedback in games have its limitations. Since users are often occupied with the game, it’s hard for game designers to get real-time, objective opinions from the player. This goal of this research is to build a model that take the GSR signal and postures as input and perform a real-time engagement evaluation that is going to help game designer capture the moment of dissatisfaction.
Recharging Methods of Electric Vehicles in Residential Distribution Systems

Received: 12 August 2019 Accepted: 16 November 2019 This paper presents unplanned and smart charging of Electric Vehicles (EV’s) in residential distribution systems. EVs are becoming attractive solution due to zero emission and efficient mode of transportation compared to conventional vehicles based on internal combustion engines. Electric Vehicle chargers are considered as irregular loads, which can affect the performance of distribution systems. Power utilities are facing challenges of possible overburdens, stresses, deviations in voltages and power losses from EV charging stations. The distribution network faces the possibilities of power outages and frequent voltage variations, which might be the result of unmanaged EV charging. This paper put forward a Smart Load Management (SLM) control methodology to control and manage several EV charging activities to reduce the stress on the distribution network and to improve distribution system reliability, security and the performance. Residential distribution system is simulated in MATLAB with unplanned charging of electric vehicles and results have been presented. The same residential distribution system is simulated with proposed algorithm and results are compared with unplanned charging of electric vehicles.
Optimal Decisions and Coordination in a Socially Responsible Supply Chain with Irresponsibility Risk

Many companies make some stakeholders pleased but others cannot. To help understand why, it is very important to study the coexistence of corporate social responsibility (CSR) and corporate social irresponsibility (CSI). This paper considers a manufacturer with irresponsibility risk in a centralized and decentralized socially responsible supply chain, and uses a Stackelberg game to investigate the optimal policies on price and CSR investment level. This paper also examines the influence of consumer responsibility awareness and CSR investment efficiency on the decision behaviors of the manufacturer and retailer. Moreover, we developed a new mechanism to coordinate the decentralized supply chain system, which consists of the retailer participating in CSR and revenue sharing. Our results indicate that the manufacturer’s and retailer’s optimal decisions may not be significantly influenced by consumer responsibility awareness, but the effect of CSR investment efficiency is significant. Our results also show that if the degree of retailer participation and the proportion of revenue sharing are of moderate size, then not only can the contract mechanism coordinate the decentralized socially responsible supply chain, but it can ensure that a win–win situation can be achieved by the supply chain members.