Miracle-dz/UniFAR-FTUs huggingface dataset:
Benefits of Yoga in Respiratory Diseases

Breathing sustains life, natural breathing brings happiness and keep healthy. It clears the mind and calms all the emotions hence it can helps in release of the vitalizing flow of energy within us. Air pollution is responsible for various respiratory diseases such as nasal allergy, asthma, chronic bronchitis and lung cancer. It has been found that Yoga has improved pulmonary parameters in several scientific studies, both in healthy as well as in diseased individuals. It helps in increase in vital capacity, tidal volume, FeV1, Fev1/FVC ratio, expiratory reserve volume, breath holding time and many other pulmonary parameters. These changes suggest a potential preventive and therapeutic role of yoga in pulmonary diseases.It is a method of learning which aims to attain the unity of mind, body and spirit through three main yoga steps includes exercise, breathing and meditation. Results of previous research studies report that many people with serious respiratory ailments have found a solution in yoga. It has been proventhattheyogic practices help in prevention, control as well as rehabilitation of many respiratory diseases. A vital scientific and therapeutic aspect of yoga is Pranayama. Few exercises of pranayama are like Anulomaviloma, Kapalbhati, Bhramari which are the components of yoga and are the best remedies which can be help to tackle respiratory illness caused by air pollution and other naturally occurring respiratory diseases.
Randomized phase III study of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic adenocarcinoma of the pancreas (MPACT).

LBA148 Background: nab-Paclitaxel (nab-P, 130 nm albumin-bound paclitaxel) provides tumor selective localization via transcytosis across the endothelium, potential tumor uptake via macropinocytosis, and improved pharmacokinetics vs cremophor-paclitaxel. In vitro, nab-P increased tumoral gemcitabine (G) levels, and in a phase I/II study in metastatic pancreatic cancer (mPC) nab-P + G showed promising activity. Methods: Patients (pts) with mPC were randomized to nab-P 125 mg/m2, followed by G 1000 mg/m2 on days 1, 8, and 15 every 4 weeks or G 1000 mg/m2 weekly for 7 weeks (cycle 1), then on days 1, 8, and 15 every 4 weeks (≥ cycle 2). For the primary endpoint of overall survival (OS), 608 events from 842 patients provided a power of 0.9 to detect a HR of 0.769 (2-side α = 0.049). Results: 861 pts received therapy. Baseline pt characteristics were well balanced. Median age was 63 years, Karnofsky performance status was 90-100 in 60% and ≤80 in 40% of pts, 43% had head of pancreas lesions, 84% had liver and 3.
266Loss of pumilio 1 phosphorylation turns off the regulation of miRNA-221 on gene p27kip1 in the heart

MicroRNAs regulate gene expression post-transcriptionally via complementary sequence pairing of mRNA 3'UTR and miRNA seed region. MiR-221 downregulates p27kip1 Cyclin-dependent kinase inhibitor 1B (p27), a cell cycle inhibitor, through direct targeting. The down-regulation of p27 caused by miR-221 upregulation induces cancer cell proliferation and has been reported to be closely associated with human cancer metastasis. This regulation is dependent on the existence of pumilio 1 (PUM1). Meanwhile miR-221 mimics protect cardiac myocytes against ischemic injury. It is a potential therapeutic target for cardioprotection. We investigated whether miR-221 targeted p27 in the heart. To test the hypothesis that the regulation of miR-221 on p27 is abolished in the heart due to lack of RNA binding protein (RBP) PMU1 phosphorylation but not due to p27 3'UTR shortening. Primary cardiac fibroblasts (cFB) were isolated and cultured under normoxia and hypoxia. After transfections of miR-221 mimics and mimic control (MC), cell proliferation was assessed by cell number, CCk-8 and Ki67 staining. In vivo rats undergoing left coronary artery ligation (MI) and Sham were treated with intravenous miR-221 mimics. Cells or cardiac tissue were collected to measure p27 and PUM1 by RT-qPCR and Western blot (WB). Full length p27 (coding plus 3'UTR sequence) and 3'UTR p27 sequence were quantified using specific primers. The ratio of 3'UTR/Full length was compared to indicate changes between groups. The ratios of 3'UTR/Full length were compared to indicate changes between groups. MiR-221 mimics significantly downregulated the expression of p27 mRNA and protein in cFB in both normoxia and hypoxia. P27 downregulation led to cFB proliferation, which could be abrogated by p27 overexpression. miR-221 mimic treatment increased cardiac miR-221 by ∼2–5 fold in Sham and ∼15 fold in MI. Whilst p27 expression was not affected in either Sham or MI hearts. Simultaneously α-SMA+ cells, an indication of cFB number and activation, were reduced by miR-221 mimic in Sham and MI heart. The ratios of p27 3'UTR/full length did not vary significantly between cultured cFB and heart (Sham and MI), indicating the 3'UTR length did not vary between cFB and the whole heart. PUM1 mRNA expression was stable in cFB and the heart. However, phosphorylated PUM1 was highly expressed in cFB but completely diminished in Sham and MI hearts. MiR-221 downregulated p27 in primary cFB and induced cell proliferation in vitro. miR-221 could not regulate cardiac p27 expression nor increase cFB proliferation in vivo. MiR-221 induced p27 regulation was correlated with the presence or absence of phosphorylated PUM1. For the first time, we demonstrated that loss of phosphorylated PUM1 turns off the regulation of miRNA-221 on gene p27 in the heart. The mechanism of PUM1 phosphorylation warrant future investigation.
Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis

This large, retrospective case-control study of electronic health records from 56 million unique adult patients examined whether or not treatment with a Tumor Necrosis Factor (TNF) blocking agent is associated with lower risk for Alzheimer’s disease (AD) in patients with rheumatoid arthritis (RA), psoriasis, and other inflammatory diseases which are mediated in part by TNF and for which a TNF blocker is an approved treatment. The analysis compared the diagnosis of AD as an outcome measure in patients receiving at least one prescription for a TNF blocking agent (etanercept, adalimumab, and infliximab) or for methotrexate. Adjusted odds ratios (AORs) were estimated using the Cochran-Mantel-Haenszel (CMH) method and presented with 95% confidence intervals (CIs) and p-values. RA was associated with a higher risk for AD (Adjusted Odds Ratio (AOR) = 2.06, 95% Confidence Interval: (2.02–2.10), P-value <0.0001) as did psoriasis (AOR = 1.37 (1.31–1.42), P <0.0001), ankylosing spondylitis (AOR = 1.57 (1.39–1.77), P <0.0001), inflammatory bowel disease (AOR = 2.46 (2.33–2.59), P < 0.0001), ulcerative colitis (AOR = 1.82 (1.74–1.91), P <0.0001), and Crohn’s disease (AOR = 2.33 (2.22–2.43), P <0.0001). The risk for AD in patients with RA was lower among patients treated with etanercept (AOR = 0.34 (0.25–0.47), P <0.0001), adalimumab (AOR = 0.28 (0.19–0.39), P < 0.0001), or infliximab (AOR = 0.52 (0.39–0.69), P <0.0001). Methotrexate was also associated with a lower risk for AD (AOR = 0.64 (0.61–0.68), P <0.0001), while lower risk was found in patients with a prescription history for both a TNF blocker and methotrexate. Etanercept and adalimumab also were associated with lower risk for AD in patients with psoriasis: AOR = 0.47 (0.30–0.73 and 0.41 (0.20–0.76), respectively. There was no effect of gender or race, while younger patients showed greater benefit from a TNF blocker than did older patients. This study identifies a subset of patients in whom systemic inflammation contributes to risk for AD through a pathological mechanism involving TNF and who therefore may benefit from treatment with a TNF blocking agent.
La luxation récidivante antérieure de l'épaule survenant après 40 ans.

: Twenty-four recurrent dislocations of the shoulder with an onset after the age of 40 years have been operated on using the Trillat technique. The results have been studied with a mean follow-up of 10 years. This type of lesion, which is not rare, forming five per cent of cases in the authors series between 1953 and 1982, deserves separate consideration because of the frequency of associated rupture of the rotator cuff which seems to arise as a consequence of the first dislocation. There were 75 per cent of indirect tuberosity signs and 20 per cent of elevations of the humeral head before operation. It is responsible for osteoarthritis in the shoulder found in the follow-up. There were 70 per cent of osteoarthritic shoulders and 50 per cent of cases with elevation of the humeral head. The clinical results obtained, without any associated procedures on the cuff, were investigated by the criteria established for the surgery of shoulder instability (Rowe). They were satisfactory, with 63 per cent of good objective results and 88 per cent of satisfied patients. There appears to be a beneficial effect from the downward displacement of the subscapularis which should be taken into account as well as consideration of treatment for the lesions of the rotator cuff.
Brain-derived neurotrophic factor in relation to central obesity in children with sleep disordered breathing

Introduction Sleep disordered breathing (SDB) represents common comorbidities of childhood obesity leading to interrupted sleep and sleep deprivation. Sleep deprivation alters secretion of brain-derived neurotrophic factor (BDNF), which is an appetite regulator. However, little is known about the relation between BDNF and central obesity in children with SDB. The aim of the study was to evaluate BDNF level and anthropometric indices in relation to SDB in children with obesity Material and methods A prospective case-control study was conducted on 30 children with obesity (BMI > 95th percentile) and 30 healthy lean children (BMI 5th-85th percentile). Polysomnographic, anthropometric data and BDNF serum level were obtained from all included children. Serum level of BDNF and anthropometric indices of obesity were assessed in relation to SDB in children with obesity. Regression analysis was done to determine predictors for SDB in children with obesity. Results In comparison to healthy controls, anthropometric indices of central obesity were significantly higher while BDNF was significantly lower in obese children, especially those with SDB. Respiratory disturbance index has a significant positive correlation with anthropometric indices of central obesity and a significant negative correlation with BDNF level. Central obesity and decreased BDNF were associated with 2-fold increased risk for SDB. Waist circumference/height ratio and neck circumference/height ratio have 89.5%, 75% sensitivity and 81.23%, 84.62% specificity at a cutoff point > 0.62, > 0.24 respectively for prediction of SDB in children with obesity. Conclusions Central obesity and decreased BDNF represent independent predictors for SDB in children with obesity. Anthropometric indices adjusted to height are a simple screening tool for SDB in obese children.
The effect of fat mass and lean mass on Bone Mineral Density in military premenopausal women

Aims: Fat mass and lean mass are two main components that build our body weight which have different effects on bone mineral density (BMD). To investigate the relative contribution of lean and fat mass to BMD, 42 premenopausal military officers were studied. Methods: Fat mass, lean mass and BMD were measured by whole body scanning with dualenergy X-ray absorptiometry (DEXA). Correlation of fat mass and lean mass with BMD through different parts and also whole body of the subjects were calculated. Results: A negative correlation existed between BMD and fat mass in both whole body and the lower limbs but was not statistically significant. However, our analysis demonstrated that BMD had a significant positive correlation with the lean mass through upper and lower limbs. Conclusion: The results of this study indicate that the Lean mass is a strong predictor of BMD in premenopausal women in the upper and lower limbs.
GP240 Vitamin d sufficiency and cytokines level in newborns born by mothers with obesity

Introduction Presence of obesity in mothers negatively affects antenatal life and decreases the sufficiency of Vitamin D in newborns. Recently, cytokines role in the regulation of the condition of the immune system during the development and in the course of infectious diseases was actively studied. Work objective Vitamin D and cytokines level (interleukin-1β (IL-1β), interleukin-6 (IL-6)) analysis in newborns, born by mothers with obesity. Methods during the first 3 days of life a laboratory study of 78 newborns was conducted: 54 (69.2%) were born by mothers with obesity, control group (CG) – 24 (30.8%) children. Results Mean gestational age of children, born by mothers with obesity – 37.7±0.3 weeks, CG - 39.3±0.2 weeks (p<0.001). Body weight of newborns – 3345.0 [2600.0–3980.0] grams and 3350.0 [3060.0–3785.0] grams respectively. In children of mothers with obesity the level of Vitamin D was 7.7 [4.0–14.5] ng/ml, which is 1.3 times lower, than in the CG – 10.1 [7.4–16.6] ng/ml (p>0.05); IL-1β content – 23.7 [12.4–45.6] pg/ml and 8.5 [3.3–46.0] pg/ml respectively (p<0.05); IL-6 level - 84.4 [49.6–194.6] pg/ml and 26.5 [11.2–79.2] pg/ml respectively (p<0.001). In women with obesity, 45 (83.3%) children were mature, 9 (16.7%) – premature. Mean gestational age of mature newborns – 38.4±0.2 weeks, premature - 33.8±0.6 weeks (p<0.001). Body weight of mature children was 3,680.0 [2,958.0–4,040.0] grams, premature - 2,000.0 [1525–2065] grams (p<0.001). Median level of 25(OH)D in mature newborns - 8.8 [4.0–14.6] ng/ml, in premature – 4.0 [3.9–4.5] ng/ml (p<0.01); IL-1β - 20.4 [11.2–34.0] pg/ml and 38.1 [32.0–93.8] pg/ml respectively (p<0.01); IL-6 - 84.6 [56.6–166.8] pg/ml, versus 64.6 [32.0–161.6] pg/ml (p>0.05). In mothers with obesity, 14 (25.9%) newborns had intrauterine infection, calcidiol level was 6.4 [4.0–13.4] ng/ml; IL-1β - 17.4 [9.2–23.9] pg/ml; IL-6 - 92.8 [45.6–190.6] pg/ml, which is 3.5 times higher, than in the CG (p<0.01). Conclusions The vast majority of newborns, born by mothers with obesity, had hypovitaminosis D, these children also had conclusively high level of IL-1β and IL-6. In newborns with intrauterine infection, IL-1β and IL-6 content reaches the highest level versus the CG.
Exploring health professionals' perceptions of promoting oral health in children

Objectives: The study aimed to explore the views of health professionals with regard to their role in oral health promotion and their understanding of the issues surrounding the delivery of effective oral health promotion within their daily practice. Method: A focus group was conducted with school nurses (n=6) and health visitors (n=3) who had recently completed the ‘Evidence Based Public Health’ core module as part of their higher degree Specialist Community Public Health Nurse (SCPHN) programme of study (May 2014). A 12-item focus group interview schedule was devised in which face and content validity were established. A thematic analysis was then undertaken in which themes and sub-themes were identified. Results: Three over-arching themes were identified: the ‘responsibility’ the participants felt they had towards their clients, the responsibility the parents should have towards their children's oral health and the responsibility of the state and its policies; the main ‘barriers’ encountered in the par.
The Need for Change: An Examination of the Centers for Disease Control and Prevention's Chlamydia Screening Recommendations

Chlamydia trachomatis is a bacterial infection spread through sexual contact, including oral, anal and vaginal sex. This largely asymptomatic infection is highly prevalent in the United States and has been for the past 40 years: indeed, chlamydia is the most common sexually transmitted disease (STD) in the United States. Left untreated, chlamydia can cause Pelvic Inflammatory Disease (PID), ectopic pregnancy, and infertility in women; complications are rare in men. Screening for this infection is necessary for its control and prevention and is a matter of great importance to public health. Currently, the Centers for Disease Control and Prevention (CDC) recommend annual chlamydia screening for all sexually active women aged 25 years and younger, older women with risk factors (new sex partners or multiple sex partners), and all sexually active men who have sex with men (MSM). This thesis examines the history of the CDC's chlamydia screening recommendations, the implications of the CDC's recommendation that all sexually active young women be screened for the infection, and the barriers to following current chlamydia screening recommendations. Through a close analysis of available evidence, this thesis asserts that the CDC's chlamydia screening recommendations are inconsistent, have not been updated to align with current diagnostic testing developments, place the burden of the disease upon women, further stigmatize people who are marginalized, and most importantly, fail to include sexually active heterosexual young men, a population that transmits the infection to women. New chlamydia screening recommendations are necessary based on the lack of control over disease prevalence, the unequal burden of the disease on women, and the increased feasibility of diagnostic measures for men. Consequently, the CDC's guidelines should be updated. The guidelines should continue to recommend the annual screening of all sexually active women aged 25 and under and also recommend the annual screening of all sexually active young men aged 25 and under, as well as men and women over the age of 25 with risk factors.
INFLUÊNCIA DO TIPO DE PRÓTESE TOTAL DUPLA NA FUNÇÃO MASTIGATÓRIA Influence of denture type in the dual masticatory function

Introduction: The harmony of occlusal contacts is a very significant factor in the interaction of the dentures to the stomatognathic system. There is no standard occlusal that incorporates all the variables required by patients in need of removable dentures. Objective: to analyze masticatory function between different types of denture double. Methods: we performed tests of masticatory performance with artificial test food using the method of sieves. Participants (20 edentulous subjects, four males and sixteen females, aged between 44 and 87 year average of 67.1, all denture wearers double to more than 5 years and not more than 10), statistical analyzes were performed using the program Pastversion 2.15, applying the test “t” test and Analysis of Variance (ANOVA). The value of statistical significance was set at 5%, ie P ≤ 0.05. Results: the results revealed similarity between the three prostheses used in the experiment, compared the test scores of all groups masticatory However when comparing groups prostheses in use versus bilateral balanced occlusion showed better results sieves 1 and 5. Conclusion: These data suggest that the type of denture double interfere in masticatory performance and better results were seen with new prostheses.
Associatio between biomarkers in the long-term prognosis of ischemic stroke

Aim: Predicting of the stroke prognosis has utmost importance as the disease has a heavy socioeconomical burden. For this reason, instruments such as stroke severity scales, stroke volume calculations and various biomarkers are used for determination of prognosis. NIHS scale, stroke volume, stroke type, neutrophil/lymphocyte ratio and C-reactive protein levels were reported to be associated with stroke prognosis. In this study we aim to investigate the relationship between these parameters with 8-year-survival from stroke. Materials and Methods: Between January 2010 and January 2012, all patients aged over 18 and diagnosed with arterial stroke were retrospectively investigated. Data regarding survival status were obtained from Death Reporting System (https://obs.gov.tr/) under the surveillance of Ministry of Health. NIHS scale, stroke volume, stroke subtype, neutrophil/lymphocyte ratio and C- reactive protein levels were obtained and compared in deceased and living patients and association between those parameters and survival was sought. Results: Advanced age, male gender, NIHS scale, stroke volume, stroke subtype, neutrophil/lymphocyte ratio were associated with stroke survival. C-reactive protein levels were not be found associated. Conclusion: Our results were consistent with the literature and, NIHS scale, stroke volume, stroke subtype, neutrophil/lymphocyte ratio predicted the stroke prognosis. As there is not enough data present in the literature, our findings were remarkable.
A phase Ib study of pembrolizumab following trans-arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC): PETAL

e16195 Background: Trans-arterial chemoembolization (TACE) is the gold-standard for intermediate stage HCC. We hypothesised the ischemic and cytotoxic effect of TACE to boost anti-cancer immunity and to synergise with the anti PD-1 pembrolizumab (pembro). We designed a phase Ib study to test the safety and preliminary efficacy of pembro after TACE in intermediate HCC. Methods: PETAL study will enroll up to 32 patients with intermediate HCC to receive pembro 200 mg every 3 weeks for up to 1 year or until disease progression or unacceptable toxicity. The first safety-run-in phase includes 6 patients: if no dose limiting toxicities (DLTs) emerge over a 21-day window after first pembro, the others are enrolled in the expansion phase. Pembro is given within 30 days after 1 or 2 TACEs. The first phase includes 1 patient scoring Child-Pugh (CP)-B7 and the remaining have to be CP-A. Safety is the primary endpoint and is measured as the incidence of treatment-related adverse events (TRAEs), graded according to NCI CTCAEv4. Efficacy is the secondary endpoint and is evaluated as progression free survival (PFS) from first TACE, according to mRECIST criteria. Survival is estimated using Kaplan-Meier method. All the patients who have received at least one dose of pembro are evaluable for safety. Results: At the time of data cut-off, on the 14th of January 2022, 14 patients had received at least one dose of pembro. The median age was 72 (IQR: 63.3-74.6), 79% were male, 71% were cirrhotic, 29% had viral hepatis and 43% ECOG PS 1. One patient had Child-Pugh (CP) class B7 and 13 had A. The median number of nodules was 1.5 (IQR:1-2.8), and 4.1 cm (IQR: 3.7-4.5) the median diameter. Overall, 5 patients received 2 TACEs and 9 had 1. Patients received a median of 4.5 cycles (IQR: 2.3-6.5) of pembro. No DLTs emerged in the first phase. Treatment-related adverse events (TRAE) of any grade (G) were reported in 86% of participants, 21% of participants experienced G3 TRAEs, and there were no G4 or G5 TRAEs. Specific skin-related toxicity was the most frequently reported (35%) TRAE. No patients had treatment-related liver toxicity. Causes of treatment discontinuation were PD (n=7), TRAEs (n=1), clinical deterioration in the CP B patient (n=1), COVID pandemic (n=2) and withdrawal of consent (n=1); at the time of data cut-off, mPFS from first TACE was 10.8 months (95%CI: 6.63-14.97). Conclusions: Adjuvant pembro following TACE is manageable and tolerable with signs of activity. These results prompt the investigation in larger trials. Clinical trial information: NCT03397654. [Table: see text]