Miracle-dz/UniFAR-FTUs huggingface dataset:
HIV-related disabilities: an extra burden to HIV and AIDS healthcare workers?

Background: Healthcare workers have been at the forefront of dealing with the impact of HIV and AIDS at all stages of the pandemic. This brings new challenges to include disability into HIV care. However, the implications for healthcare workers in an already fragile health system along with HIV-related disabilities in persons living with HIV are little understood. This study examined the healthcare workers’ perspective on disability in HIV care. Method: This article describes a qualitative study using in-depth interviews with 10 healthcare workers in a semi-urban hospital setting in KwaZulu-Natal, South Africa. The study aimed to understand healthcare workers’ experiences with disability in the context of HIV. The International Classification of Functioning Disability and Health (ICF) was used as a guiding framework to understand disability. Results: Healthcare workers described HIV-related disabilities on all three levels of disability, namely impairments/ body function, activity limitations and participation restrictions, as affecting the livelihood of their patients and household members. Issues also arose from disability and stigma that were perceived as affecting adherence to antiretroviral treatment. In addition, healthcare workers encounter challenges in dealing with the increased needs of care and support for those people living with HIV who experience HIV-related disabilities. They indicated a limited ability to cope and respond to these needs. Primarily they arrange additional referrals to manage complex or episodic disabilities. Participants also identified issues such as excessive work load, lack of resources and training and emotional challenges in dealing with disability. Conclusion: Healthcare workers need support to respond to the increased needs of people living with HIV who have HIV-related disabilities. Responses need to reflect: 1) increase in rehabilitative staff including in community outreach programmes; 2) skills training in HIV-related disability; and 3) psychosocial support for healthcare workers.
Children's emotional associations with colors.

In this study children's emotional associations with colors were investigated. Sixty children (30 girls, 30 boys), equally divided into groups of 5-year-olds and 6 1/2-year-olds, were asked their favorite color and were then shown nine different colors, one at a time and in a random order. For each color, children were asked, "How does (the color) make you feel? " All children were able to verbally express an emotional response to each color, and 69% of children's emotional responses were positive (e.g., happiness, excitement). Responses also demonstrated distinct color-emotion associations. Children had positive reactions to bright colors (e.g., pink, blue, red) and negative emotions for dark colors (e.g., brown, black, gray). Children's emotional reactions to bright colors became increasingly positive with age, and girls in particular showed a preference for brighter colors and a dislike for darker colors. Boys were more likely than girls were to have positive emotional associations with dark colors. Potential sources for children's color-emotion concepts, such as gender-related and idiosyncratic experiences, are discussed.
Evidence for Cooperativity between the Four Binding Sites of Dimeric ArsD, an As(III)-responsive Transcriptional Regulator*

ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli. It possesses two-pairs of vicinal cysteine residues, Cys12-Cys13 and Cys112-Cys113, that potentially form separate binding sites for the metalloids that trigger dissociation of ArsD from the operon. However, as a homodimer it has four vicinal cysteine pairs. Titration of the steady-state fluorescence of ArsD with metalloids revealed positive cooperativity, with a Hill coefficient of 2, between these sites. Disruption of the Cys112-Cys113site by mutagenesis of arsD, but not the Cys12-Cys13 site, largely abolished this cooperativity, indicative of interactions between adjacent Cys112-Cys113 sites within the dimer. The kinetics of metalloid binding were determined by stopped flow spectroscopy; the rate increased in a sigmoidal manner, with a Hill coefficient of 4, indicating that the pre-steady-state measurements reported cooperativity between all four sites of the dimer rather than just the intermolecular interactions reported by the steady-state measurements. The kinetics of Sb(III) displacement by As(III) revealed that the metalloid-binding sites behave differentially, with the rapid exchange of As(III) for Sb(III) at one site retarding the release of Sb(III) from the other sites. We propose a model involving the sequential binding and release of metalloids by the four binding sites of dimeric ArsD, with only one site releasing free metalloids.
Battery State-Of-Charge Estimation Based on a Dual Unscented Kalman Filter and Fractional Variable-Order Model

State-of-charge (SOC) estimation is essential for the safe and effective utilization of lithium-ion batteries. As the SOC cannot be directly measured by sensors, an accurate battery model and a corresponding estimation method is needed. Compared with electrochemical models, the equivalent circuit models are widely used due to their simplicity and feasibility. However, such integer order-based models are not sufficient to simulate the key behavior of the battery, and therefore, their accuracy is limited. In this paper, a new model with fractional order elements is presented. The fractional order values are adaptively updated over time. For battery SOC estimation, an unscented fractional Kalman filter (UFKF) is employed based on the proposed model. Furthermore, a dual estimation scheme is designed to estimate the variable orders simultaneously. The accuracy of the proposed model is verified under different dynamic profiles, and the experimental results indicate the stability and accuracy of the estimation method.
A Fuzzy-Multiagent Service Restoration Scheme for Distribution System With Distributed Generation

This paper proposes a new multiagent control system (MACS) for service restoration in distribution systems with integrated distributed generation (DG) units. First, the MACS detects and locates faults, then decides the optimal reconfiguration of the network for restoring de-energized loads, and finally regulates the nodes voltages. Unintentional islanding operation of DG units is avoided and different postfault response modes of DG unit are addressed in the MACS design. The MACS has a hybrid centralizeddecentralized structure where agents are arranged in two layers with different responsibilities and communication capabilities. Agents at load buses in the first layer can only communicate directly with its next neighbor load agents on the same feeder and to its feeder agent, whereas the higher level agents in the second layer can communicate directly with each other. This MACS structure reduces the possibilities of control system failures for a moderate communication network infrastructure. Full dynamic simulation model for evaluating the MACS is implemented.
Ulcerative colitis and colorectal cancer. A population-based study.

BACKGROUND The risk of colorectal cancer is increased among patients with ulcerative colitis. The magnitude of this increase in risk and the effects of the length of follow-up, the extent of disease at diagnosis, and age at diagnosis vary substantially in different studies. METHODS To provide accurate estimates of the risk of colorectal cancer among patients with ulcerative colitis, we studied a population-based cohort of 3117 patients given a diagnosis of ulcerative colitis from 1922 through 1983 who were followed up through 1984. RESULTS Ninety-two cases of colorectal cancer occurred in 91 patients. As compared with the expected incidence, the incidence of colorectal cancer in the cohort was increased (standardized incidence ratio [ratio of observed to expected cases] = 5.7; 95 percent confidence interval, 4.6 to 7.0). Less extensive disease at diagnosis was associated with a lower risk; for patients with ulcerative proctitis, the standardized incidence ratio was 1.7 (95 percent confidence interval, 0.8 to 3.2); for those with left-sided colitis, 2.8 (95 percent confidence interval, 1.6 to 4.4); and for those with pancolitis (extensive colitis, or inflammation of the entire colon), 14.8 (95 percent confidence interval, 11.4 to 18.9). Age at diagnosis and the extent of disease at diagnosis were strong and independent risk factors for colorectal cancer. For each increase in age group at diagnosis (less than 15 years, 15 to 29 years, 30 to 39 years, 40 to 49 years, 50 to 59 years, and greater than or equal to 60 years), the relative risk of colorectal cancer, adjusted for the extent of disease at diagnosis, decreased by about half (adjusted standardized incidence ratio = 0.51; 95 percent confidence interval, 0.46 to 0.56). The absolute risk of colorectal cancer 35 years after diagnosis was 30 percent for patients with pancolitis at diagnosis and 40 percent for those given this diagnosis at less than 15 years of age. CONCLUSIONS Close surveillance and perhaps even prophylactic proctocolectomy should be recommended for patients given a diagnosis of pancolitis, especially those who are less than 15 years of age at diagnosis.
Electrophysiological correlates of face distortion after-effects

When observers are exposed to a distorted face the perceived configuration of a subsequently presented face is altered, a phenomenon called face distortion after-effect (FDAE). We compared the face-related components of the event-related potential (ERP) after adaptation to noise images—veridical and distorted faces. We found large bilateral adaptation effects on the P100 and N170 components that are related to face detection. Moreover, we found smaller adaptation effects on the N170, recorded over the right hemisphere, which can be related to the behavioural distortion after-effect and to face configurations. Our results suggest that the observed ERP adaptation effects are general for various steps of face processing and that the FDAEs similarly to gender after-effects are related to the early face-specific ERP components.
Maximizing Throughput of Delay-Sensitive NFV-Enabled Request Admissions via Virtualized Network Function Placement

Network Function Virtualization (NFV) has attracted significant attention from both industry and academia as an important paradigm change in network service provisioning. Most existing studies on admissions of NFV-enabled requests focused on deploying dedicated Virtualized Network Function (VNF) instances to serve each individual request without exploring the sharing of VNF instances among multiple user requests. However, with ever-growing demands of user services, exclusive usages of VNF instances in most networks drastically degrade the network performance and largely under-utilize the VNF instance resources. In this paper, we jointly explore two different VNF instance scaling techniques, horizontal scaling and vertical scaling techniques, to improve the network throughput while minimizing the operational cost of the network, where horizontal scaling that migrates some existing VNF instances from their current locations to new locations to allow the VNF instances to be shared by multiple requests to reduce the resource consumption and operational cost of the network, and vertical scaling that instantiates new VNF instances to meet the demands of new request admissions if existing VNF instances sharing becomes more expensive or the end-to-end delay requirements of currently executing requests will be violated. We first propose a unified framework of maximizing the network throughput, by admitting as many as NFV-enabled requests while meeting the end-to-end delay requirements of the admitted requests. We then provide an Integer Linear Programming (ILP) solution for the problem when the problem size is small. Otherwise, we devise an efficient algorithm through a non-trivial reduction that reduces the problem to the minimum-weight feedback arc set problem and the generalized assignment problem (GAP). We finally conduct experiments to evaluate the performance of the proposed algorithm. Experimental results demonstrate that the proposed algorithm outperforms a baseline algorithm and achieves a performance on a par with its optimal ILP solution.
Patient-controlled sedation: a novel approach to sedation management for mechanically ventilated patients.

BACKGROUND Patient self-administration of medications for analgesia and procedural sedation is common. However, it is not known whether mechanically ventilated ICU patients can self-administer their own sedation to manage symptoms. METHODS This descriptive pilot study examined the safety, adequacy, and satisfaction of patient-controlled sedation (PCS) with a convenience sample of critically ill, mechanically ventilated patients (N = 17) in the ICUs at University of Minnesota Medical Center, Fairview, Minneapolis, Minnesota. Dexmedetomidine was administered via a patient-demand infusion pump system for a maximum of 24 h. Pumps were programmed with basal infusion plus patient-triggered boluses; nurses adjusted the basal infusion based on a dosing algorithm. Data were collected on sedation adequacy, additional dosing of analgesics and sedatives, hemodynamic parameters, safety of PCS, patient satisfaction with PCS, and nurse satisfaction with PCS. RESULTS Although a majority of the hemodynamic values were within the established safety parameters for the study, 25% of patients experienced mild adverse physiologic effects. Furthermore, despite patients' perception of sedation adequacy with PCS, 70% received supplemental opiates or benzodiazepine medications while participating in the study. Patients rated dexmedetomidine PCS favorably for self-management of anxiety, level of relaxation obtained, and comfort in self-administering sedation. Nurses also were generally satisfied with PCS as a method of sedation, dexmedetomidine as the sedative, and patient response to the sedation. CONCLUSIONS PCS warrants further investigation as a means to promote comfort in mechanically ventilated critically ill patients.
Motion perception using spatiotemporal frequency analysis

Motion information is extracted by identifying the temporal signature associated with the textured objects in the scene. We present a new computational framework for motion perception. Our methodology considers spatiotemporal frequency (STF) domain analysis to extract the optical flow information. First, we show that a sequence of image frames can be used to extract the motion parameters for the different regions in a dynamic scene using the basic Fourier transform properties in the STF analysis approach. A detailed analytical description of this model to interchangably extract motion and depth parameters and results to highlight their salient properties are presented. <<ETX>>
Effect of tobacco on periodontal disease and oral cancer

INTRODUCTION Periodontal disease and oral cancer are common health hazards. Epidemiological investigations show that smoking, periodontal disease and oral cancer are closely related. Tobacco is one of the major risk factors for periodontitis and oral cancer. METHODS A systematic literature review was performed. To identify relevant studies, the following online databases were searched using specific keywords: PubMed, Web of Science and CNKI. RESULTS Tobacco not only possesses an addictive effect, but it aggravates periodontal disease by promoting the invasion of pathogenic bacteria, inhibiting autoimmune defense, aggravating the inflammatory reaction, and aggravating the loss of alveolar bone. According to current evidence, tobacco significantly aggravates the development and progression of periodontal disease and oral cancer, and periodontal disease may be related to the prevalence of oral cancer. CONCLUSIONS Clinicians should strongly recommend that smokers undertake a strategy to stop smoking to avoid the exacerbation of nicotine-related periodontal disease and to reduce the incidence of oral cancer.
Sodium – lauryl – sulphate – induced cutaneous irritation

Reactivity of white and hispanic skin after exposure to sodium tauryl sulphate (SLS) has been investigated. The tests were performed on the back as follows: untreated skin, skin pre‐treated with short‐term occlusion and delipidized skin. Irritant reactions were induced by applying 0.5% and 2.0% SLS via Finn chamber patch tests and monitored by means of laser Doppler velocimetry (LDV), transepidermal water loss (TEWL) and stratum corneum water content (WC). Higher TEWL, LDV and WC were recorded for 2.0% SLS when compared to 0.5% SLS and baselines. Differences between while and hispanic skin reactivity were recorded. TEWL and WC responses showed a greater sensitivity in hispanics possibly reflecting a different modulation of the water burner function after chemical exposure. On the other hand, the microcirculatory response, as long as detected with LDV, was similar in the 2 groups. Correlations between these data and findings observed in other races are discussed.
CD44 in Cancer

CD44 is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, chemokines, and growth factors to the corresponding receptors, and docking of proteases at the cell membrane, as well as in signaling for cell survival. All these biological properties are essential to the physiological activities of normal cells, but they are also associated with the pathologic activities of cancer cells. Experiments in animals have shown that targeting of CD44 by antibodies, antisense, and CD44-soluble proteins markedly reduces the malignant activities of various neoplasms, stressing the therapeutic potential of anti-CD44 agents. Furthermore, because alternative splicing and posttranslational modifications generate many different CD44 sequences, including, perhaps, tumor-specific sequences, the production of anti-CD44 tumor-specific agents may be a realistic therapeutic approach. However, in many cancers (renal cancer and non-Hodgkin's lymphomas are exceptions), a high level of CD44 expression is not always associated with an unfavorable outcome. On the contrary, in some neoplams CD44 upregulation is associated with a favorable outcome. Even worse, in many cases different research groups analyzing the same neoplastic disease reached contradictory conclusions regarding the correlation between CD44 expression and disease prognosis, possibly due to differences in methodology. These problems must be resolved before applying anti-CD44 therapy to human cancers
Whole-organism high-throughput screening against Trypanosoma brucei brucei

Introduction: Human African trypanosomiasis (HAT) occurs as a result of infection with the protozoan parasites Trypanosoma brucei gambiense and T.b. rhodesiense and is nearly always fatal without treatment. However, current therapeutic options are severely limited and there is a desperate need for new compounds to treat the disease. Whole-cell high-throughput screening (HTS) is a technique frequently used to identify compounds with trypanocidal activity. Areas covered: The authors examine the development of whole-organism HTS assays for T.b. brucei. The authors describe the successes achieved through HTS and discuss the advantages and disadvantages of whole-organism HTS. Expert opinion: Despite hundreds of trypanocidal molecules being identified by whole-organism HTS, very few have progressed into preclinical development. The failure of molecules identified by HTS to progress along the drug development pathway is due to a multitude of factors including undrug-like molecules and molecules having poor pharmacodynamics/kinetic properties. Future studies should focus on screening libraries that contain drug-like molecules that possess some of the properties required in the final compound.
Sedation during spinal anesthesia.

BACKGROUND Central neuraxial anesthesia has been reported to decrease the dose of both intravenous and inhalational anesthetics needed to reach a defined level of sedation. The mechanism behind this phenomenon is speculated to be decreased afferent stimulation of the reticular activating system. The authors performed a two-part study (nonrandomized pilot study and a subsequent randomized, double-blind, placebo-controlled study) using the Bispectral Index (BIS) monitor to quantify the degree of sedation in unmedicated volunteers undergoing spinal anesthesia. METHODS Twelve volunteers underwent BIS monitoring and observer sedation scoring (Observer's Assessment of Alertness/Sedation Scale [OAA/S]) before and after spinal anesthesia with 50 mg hyperbaric lidocaine, 5%. Subsequently, 16 volunteers blinded to the study were randomized to receive spinal anesthesia with 50 mg hyperbaric lidocaine, 5% (n = 10) or placebo (n = 6) and underwent BIS and OAA/S monitoring. RESULTS In part I, significant changes in BIS scores of the volunteers occurred progressively (P = 0.003). The greatest variations from baseline BIS measurement occurred at 30 and 70 min. In part II, there were significant decreases in OAA/S and self-sedation scores for patients receiving spinal anesthesia versuscontrol patients (P = 0.04 and 0. 01, respectively). The greatest decrease in OAA/S scores occurred at 60 min. BIS scores were similar between groups (P = 0.4). CONCLUSIONS Spinal anesthesia is accompanied by significant sedation progressively when compared with controls as measured by OAA/S and self-sedation scores. This effect was not related to block height. The late sedation observed by OAA/S at 60 min may indicate a second mechanism of sedation, such as delayed rostral spread of local anesthetics. BIS was not a sensitive measure of the sedation associated with spinal anesthesia in the randomized, blinded portion of this study.
A compact fractal structure based rectenna with the rectifier circuit integrated

A compact rectenna using a microstrip patch antenna based on a fractal model and with the rectifier circuit integrated into the same physical structure has been designed and implemented. The proposed compact rectenna, implemented on a low cost FR-4 substrate, can harverst RF power from 2.4 GHz (ISM band) with a good efficiency (∼48%). The suggested rectenna has been manufactured and experimentally characterized, showing a good agreement with the expected simulated results.