Miracle-dz/UniFAR-FTUs huggingface dataset:
Synaptic Specificity in the Zebrafish Lateral Line

The proper wiring of the vertebrate brain represents an extraordinary developmental challenge, requiring billions of neurons to select their appropriate synaptic targets. In view of this complexity, simple vertebrate systems provide necessary models for understanding how synaptic specificity arises. The posterior lateral-line organ of larval zebrafish consists of polarized hair cells organized in discrete clusters known as neuromasts. Here I show that each afferent neuron of the posterior lateral line establishes specific contacts with hair cells of the same hair-bundle polarity. I quantify this specificity by modeling the neuron as a biased selector of hair-cell polarity and find evidence for bias from as early as 2.5 days post-fertilization. More than half of the neurons form contacts on multiple neuromasts, but the innervated organs are spatially consecutive and the polarity preference is consistent. Using a novel reagent for correlative electron microscopy, HRP-mCherry, I show that these contacts are indeed afferent synapses bearing vesicle-loaded synaptic ribbons. Moreover, afferent neurons reassume their biased innervation pattern after hair-cell ablation and regeneration. By documenting specificity in the pattern of neuronal connectivity during development and in the context of organ regeneration, these results establish the posterior lateral-line organ as a vertebrate system for the in vivo study of synaptic specificity. In order to shed light on the mechanism for this specificity, I investigated whether afferent neurons distinguish hair-cell polarities by analyzing differences in the synaptic signaling between oppositely polarized hair cells. By examining two mutant zebrafish lines with defects in mechanoelectrical transduction, I found that afferent neurons can form specific synapses in the absence of stimulus-evoked patterns of synaptic release. Asking next whether this specificity could arise through intrinsically generated patterns of synaptic release, I found that the polarity preference persisted in two mutant lines lacking essential synaptic proteins. These results indicate that lateral-line afferent neurons do not utilize synaptic activity to distinguish hair-cell polarities and suggest that molecular markers of hair-cell polarity guide prepatterned afferents to form the appropriate synapses. iii ACKNOWLEDGMENTS I would never have reached this point without the support and encouragement of my family. I wish to thank: my parents, Moises and Ruth, for dedicating their lives to the care of my siblings and me, spoiling us with a peaceful and nurturing home environment; Isaac and Belanie, my siblings, who although younger than me, continue to impress me through their hard work and enthusiastic pursuit of success; my grandparents, Zeide and Bube, …
Moderately clipped LASSO for the high-dimensional generalized linear model

The least absolute shrinkage and selection operator (LASSO) is a popular method for a high-dimensional regression model. LASSO has high prediction accuracy; however, it also selects many irrelevant variables. In this paper, we consider the moderately clipped LASSO (MCL) for the high-dimensional generalized linear model which is a hybrid method of the LASSO and minimax concave penalty (MCP). The MCL preserves advantages of the LASSO and MCP since it shows high prediction accuracy and successfully selects relevant variables. We prove that the MCL achieves the oracle property under some regularity conditions, even when the number of parameters is larger than the sample size. An e ﬃ cient algorithm is also provided. Various numerical studies conﬁrm that the MCL can be a better alternative to other competitors.
Grappling with anisotropic data, pseudo-merohedral twinning and pseudo-translational noncrystallographic symmetry: a case study involving pyruvate kinase

Biomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8041, New Zealand, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Victoria, Australia, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia, and Institute of Fundamental Sciences, Massey University, PO Box 11-222, Palmerston North 4442, New Zealand. *Correspondence e-mail: renwick.dobson@canterbury.ac. nz
Analysis of Soybean Price Transmission between Major Brazilian Producing Areas: A Co-integration and Causality Approach

Soybean production plays a significant role in both the Brazilian and in the world economy. A relevant issue to be observed in agribusiness management is related to its price transmission. The main objective of this paper aims to analyze the price transmission process among major Brazilian soybean producing areas: States of Mato Grosso, Paraná, Rio Grande do Sul and Goiás, covering the period from January 2008 to December 2015. In order to fulfill this objective a bivariate co-integration test for soybean prices, as well as the autoregression vector model (VAR) for the Granger causality analysis and function Impulse response. The results showed that there is price transmission between all the states analyzed, except for the State of Goiás.
Dark Matter in Gauge Mediation from Emergent Supersymmetry

We investigated the viability of neutralino dark matter in the gauge mediation from emergent supersymmetry proposal. In this proposal, supersymmetry is broken at Planck scale and consequently, the gravitino is superheavy and completely decouples from the low energy theory. Squarks and sleptons obtain their soft masses dominantly through gauge mediation with other mechanisms highly suppressed. The lightest supersymmetric partner, in contrast to traditional gauge mediation, is a neutralino which is also a dark matter candidate. By explicit calculation of the low energy spectra, the parameter space was constrained using the WMAP observed relic density of dark matter, LEP2 Higgs mass bounds, collider bounds on supersymmetric partners and exotic B-meson decays. We found that the model has intriguing hybrid features such as a nearly gauge-mediated spectrum (the exception being the superheavy gravitino) but with a dominant mSUGRA-like binostau coannihilation channel and at large tanβ, A-resonance-like annihilation.
Intelligent Autonomous Wheelchair for Indoor Navigation

- Manually controlling an electric powered wheelchair is a challenging task, especially for dependent individuals with movement disabilities. A solution to improve user’s mobility is to implement an autonomous navigation algorithm on powered wheelchairs. This paper presents a unique approach to achieve inexpensive and robust semi-autonomous assisted navigation for existing powered wheelchairs. Our prototype wheelchair platform is capable of localization, as well as robust obstacle avoidance, using only a commodity RGB-D camera and wheel odometry. It uses the localization data to autonomously plan and traverse to the desired goal locations in a known indoor environment.
University of Dundee Glycaemic control trends in people with Type 1 diabetes in Scotland 2004-2016 Scottish Diabetes Research Network Epidemiology Group; Mair, Colette; Wulaningsih,

Aims/hypothesis The aim of this work was to examine whether glycaemic control has improved in those with type 1 diabetes in Scotland between 2004 and 2016, and whether any trends differed by sociodemographic factors. Methods We analysed records from 30,717 people with type 1 diabetes, registered anytime between 2004 and 2016 in the national diabetes database, which contained repeated measures of HbA1c. An additive mixed regression model was used to estimate calendar time and other effects on HbA1c. Results Overall, median (IQR) HbA1c decreased from 72 (21) mmol/mol [8.7 (4.1)%] in 2004 to 68 (21)mmol/mol (8.4 [4.1]%) in 2016. However, all of the improvement across the period occurred in the latter 4 years: the regression model showed that the only period of significant change in HbA1c was 2012–2016 where there was a fall of 3 (95% CI 1.82, 3.43) mmol/mol. The largest reductions in HbA1c in this period were seen in children, from 69 (16) mmol/mol (8.5 [3.6]%) to 63 (14) mmol/mol (7.9 [3.4]%), and adolescents, from 75 (25) mmol/mol (9.0 [4.4]%) to 70 (23) mmol/mol (8.6 [4.3]%). Socioeconomic status (according to Scottish Index of Multiple Deprivation) affected the HbA1c values: from the regression model, the 20% of people living in the most-deprived areas had HbA1c levels on average 8.0 (95%CI 7.4, 8.9) mmol/mol higher than those of the 20% of people living in the least-deprived areas. However this difference did not change significantly over time. From the regression model HbA1c was on average 1.7 (95% CI 1.6, 1.8) mmol/mol higher in women than in men. This sex difference did not narrow over time. Conclusions/interpretation In this high-income country, we identified a modest but important improvement in HbA1c since 2012 that was most marked in children and adolescents. These changes coincided with national initiatives to reduce HbA1c including an expansion of pump therapy. However, in most people, overall glycaemic control remains far from target levels and further improvement is badly needed, particularly in those from more-deprived areas.
Distributed execution and evaluation system

DJEES is a distributed system for job execution and evaluation. It was implemented using the latest technologies. The core of the system is a Mesos framework that manages the cluster resources. The jobs are isolated using Docker containers, and output is persisted into the Cassandra database. The system combines distributed fault-tolerant technologies to provide a scalable, fault-tolerant environment where users can run their jobs.
Distribution of household assets in Croatia

* The author wants to thank the two anonymous referees, as well as Maja Bukovšak, Vedran Šošić, Krunoslav Zauder, Mate Rosan, Ervin Duraković, Lana Ivičić and Ivica Rubil for their useful comments and suggestions. I would like to express my gratitude to Mrs Frédérique Savignac from the HFCN, the co-author in the paper by Arrondel, Roger and Savignac (2014) for providing a part of the Stata module to integrate generalized ordered probit models with multiple imputed and weighted data. This paper presents the views of the author and should not be interpreted as reflecting the views or opinions of the Croatian National Bank. ** Received: October 21, 2019 Accepted: February 24, 2020
Predictive Factors for Endoscopic Stenting Patency and Patient Survival in Unresectable Malignant Biliary Obstruction: A Cohort Study at a Tertiary Institution

Aim: Factors associated with the biliary stent dysfunction and long-term survival are not clearly established. To analyze factors associated with stent patency in palliative biliary drainage (BD) and to evaluate the factors associated with patient survival. Material and M ethods: Observational retrospective study with consecutive inclusion of patients with unresectable biliopancreatic tumours who underwent BD by ERCP between January-2015 and December-2016. To analyze the factors associated with patient survival, the hazard ratio obtained through a Cox model was used. The follow-up review period was limited up to January 2018 (from at least one year after the endoscopic procedure) or the patient´s death. Results: Forty-four patients were included during the study period. The clinical success rate of overall biliary stents was 93.2% and total AE rate was 18.2%. The basal biliary stent was functional in 79.5%; in the remaining cases, endoscopic reinterventions were necessary. The median time until the loss of stent patency was 131 days (Q1-Q3; 85-387days). None of the parameters analyzed were associated with stent dysfunction. The patients who required endoscopic reinterventions had a longer survival time (median of 422days [Q1-Q3; 281-520] vs 162days [Q1-Q3; 37-264], p=0.001). Oncological treatment, partially covered self-expandable metal stent, and high albumin were statistically associated with a longer survival. Conclusions: The majority of biliary stents were functional, without the need to repeat the ERCP sessions. The need for stent repermeabilization did not negatively influence patient survival.
Face recognition using viola-jones depending on python

In this paper, the proposed software system based on face recognition the proposed system can be implemented in the smart building or any VIP building need security interring in general, The human face will be recognized from a stream of pictures or video feed, this technology recognizes the person according to the specific algorithm, the algorithm that employed in this paper is the Viola–Jones object detection framework by using Python. The task of the proposed facial recognition system consists of two steps, the first one was detected the human face from live video using the webcamera in the computer, and the second step recognizes if this face allowed to enter the building or not by comparing it with the existing database, the two steps depending on the OpenCV python by importing cv2 method for detecting the human face, the frames can be read or written to file with the cv2.imread and cv2.imwrite functions respectively Finally, this proposed software system can be used to control access in smart buildings as a rule and the advancement of techniques connected around there, Providing a security system is one of the most important features must be achieved in the smart buildings, this proposed system can be used as an application in a smart building as a security system. Face recognition is one of the most important applications using today for practical facial recognition. The proposed software system, depending on using OpenCV (open source computer vision) is a popular computer vision library, in 1999 this library started by Intel. The platform library sets its focus on real-time image processing and includes patent-free implementations of the latest computer vision algorithms. OpenCV 2.3. 1 now comes with a programming interface to C, C++, Python, and Android. OpenCV library of python, the three algorithms that will be used in this proposed system. The currently available algorithms are: Eigenfaces → createEigenFaceRecognizer(). Fisherfaces → createFisherFaceRecognizer(). Local Binary Patterns Histograms → createLBPHFaceRecognizer(). Finally the proposed system provide entering to the building just for the authorized person according to face recognition algorithem.
Management of Epithelial Ovarian Cancer in Older Patients in the Adam Malik Central Hospital of Medan

Ovarian cancer is the eighth most common cancer in women and is ranked 18th most common cancer in the world. Based on SEER, 47% of ovarian cancers occur in women over 65 years of age. Decreased life expectancy in older ovarian cancer patients can be due to: more aggressive cancer cells at old age; resistance of cancer cells to chemotherapy; individual patient factors; inadequate surgery and suboptimal chemotherapy. As many as 75% of women with ovarian cancer are diagnosed at an advanced stage so the prognosis is poor. Consideration of chemotherapy doses, scheduling, route and time, is very important to determine the safest and most effective treatment with consideration of geriatric assessment, such as functional dependence, organ function, comorbidity, polypharmacy, social support, and cognition/psychosocial factors. The purpose of this study was to determine the characteristics and treatment of ovarian cancer in older patients, especially in H. Adam Malik General Hospital, Medan. Data about ovarian cancer were obtained from the cancer registry, and through SIRS data (Hospital information system, Sistem informasi rumah sakit) with following keywords: ovarian cancer and malignant ovarian tumor corresponding to ICD10. After that, results search were filtered for patients older than 60 years old, and checked one by one to ensure that the patient was diagnosed with ovarian cancer. Then, the characteristics and management of the patient were obtained from the medical record. This research was conducted at Haji Adam Malik Hospital which is a class A general hospital in Medan as well as a referral hospital of Development Area A which covers the provinces North Sumatra, Nanggroe Aceh Darussalam, West Sumatra, and Riau. Through SIRS data, we found that 132 patients were diagnosed with ovarian cancer and malignant ovarian tumor from 2016-2018. From the cases registered at H Adam Malik General Hospital, only 15 cases were in accordance with screening criteria, namely patients over the age of 60 years. Most patients were aged between 66-70 years (53.33%), histopathologically had the adenocarcinoma mucinous type (33.33%), and most were in stage IIIC (20%). For surgery, we found optimal primary debulking of 53.33%, suboptimal primary debulking of 33.33% and 13,345 primary debulking were not carried out. More patients had ASA scores with a range of 0-1 (53.33%) than patients with ASA scores of 2-3 (33.33%). 5 patients had good outcome (53.33%), 1 patient passed away (33.33%), and there was as much as 53.33% loss of follow-up with unknown outcome. Conclusion: the management of ovarian cancer in older patients in Dr. H. Adam Malik Hospital is in accordance with EBM.
Title: A Review on Effect of Covid-19 in Pregnant Women Running title: A Comprehensive Analysis on Effect of COVID-19 and other viral outbreaks on Pregnant Women

Coronavirus Disease 2019 (COVID-19) is an emerging disease with a rapid increase in cases and deaths since its first discovery in December 2019, in Wuhan, China. Limited data on COVID-19 during pregnancy are available; however, information on diseases associated with other highly pathogenic coronaviruses (i.e., severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) may provide insight into the effects of COVID-19 during pregnancy. Coronaviruses cause illness ranging from the common cold to severe respiratory disease and death. The data indicate a ~5-day incubation period (range-2-14 days). The average age of hospitalized patients was 49-56 years, with an underlying illness a third to half. Children were rarely mentioned. Within hospitalized cases men were more frequent (5473 percent). Fever, cough, myalgia, vomiting and diarrhoea are common symptoms. This review aims at giving a in depth understanding on COVID-19 by comparing its effect with SARS and MERS to evaluate its severity in recent times in pregnant women. The results of varied studies showed that COVID-19 effected pregnant women at severe rate and there is an alarming need to look into this aspect in order to prevent this heinous effect on foetus.
Fistula Excision with Sphincter Repair and/ or Approximation Leaving Long Braided Sutures for Drainage of Intersphencteric Space for Management of Fistula in Ano

Background: Fistula-in-ano is the most common form of perineal sepsis. Typically, a fistula includes an internal opening, a track, and an external opening. The external opening might acutely appear following infection and/or an abscess, or more insidiously in a chronic manner. Objective: To analyze the results of surgical excision of intersphencteric, transsphencteric or suprasphencteric perianal fistula by fistula excision with sphincter repair and / or approximation leaving braided sutures for drainage Patients and method: In this prospective study a group consisted of 124 patients with intersphencteric, transsphencteric or suprasphencteric perianal fistulae were treated with fistula excision followed by sphincter repair and / or approximation leaving the ends of the threads long for drainage of intersphencteric space. All patients were observed along one year after surgery for complications, recurrence and / or incontinence Results: The technique was done under spinal anesthesia for 92 patients (74 %) and under general anesthesia for the other 32 patients (26 %). The median operative time was 30 minutes; ranging from 25 to 40 min. there were no postoperative deaths. Hospital stay was less than 24 hrs for all patients. The overall recurrence rate was 4.8 %, with no permanent incontinence. Conclusion: This technique has shown to be highly effective and applicable for management of intersphencteric, transsphencteric or suprasphencteric perianal fistula with low recurrence rate (4.8%), no permanent incontinence and good patient satisfaction.
EFFECTS OF INSECTICIDE-INDUCED REDUCTION IN LEPIDOPTERAN LARVAE ON REPRODUCTIVE SUCCESS OF HOODED WARBLERS

We examined the effects of an insecticide-induced reduction of lepidopteran larvae due to spraying of Bacillus thuringiensis to eradicate gypsy moths (Lymantria dispar) on the reproduction of Hooded Warblers (Wilsonia citrina). Treatment plots had two appli- cations of Bacillus in 1994. No Bacillus application occurred in 1995. Reductions in lepidop- teran larvae were demonstrated by pheromone traps and arthropod samples from oak (Quer- cus spp.) foliage. We analyzed the following reproductive parameters: nesting success, num- ber of eggs, number of fledglings, egg mass, mass of nestlings at day 5, growth rates, feeding rates, and prey items brought to nestlings. Of these reproductive parameters, three showed both statistical and biological differences. Nesting success was higher in the control than in the treatment zone in 1995, but not in 1994. Nestling masses at day 5 increased over the duration of the breeding season in the treatment zone but not in the control zone. Differences in feeding rates between treatment and control zones occurred only for small clutches. Over- all, the reduction of lepidopteran larvae due to Bacillus application appeared to have only minimal effects on reproduction in Hooded Warblers. Received 9 September 1996, accepted 8
Which Caribou? Misnaming population units leads to conservation

In reviewing the genetic, morphological, behavioural, and ecological distinctiveness of caribou throughout Canada, the Committee on the Status of Endangered Wildlife in Canada (COSEWIC) (2011) divided “Southern Mountain caribou” (c.f. COSEWIC 2002) into three designatable units (DU) for conservation purposes: Northern Mountain (DU7), Central Mountain (DU8), and Southern Mountain (DU9) populations of woodland caribou. These new designations mean that each is considered a “wildlife species” according to the Species at Risk Act. Recent federal and provincial government reports refer to “Southern Mountain caribou,” conflating Southern Mountain, Central Mountain, and nine of the 45 subpopulations of Northern Mountain caribou into one pseudo-population, with clear conservation consequences. For example, in 2018, a federal decision on an emergency order required the Minister of Environment and Climate Change Canada (ECCC) to ascertain whether there were immediate threats to the survival or recovery of the Southern Mountain population of woodland caribou. By conflating two ecotypes and part of another into “Southern Mountain caribou”—an obsolete, geographical grouping not used since 2002—ECCC’s assessment falsely informed the Minister that there were 3,764 “Southern Mountain caribou,” when in fact there were only 1,240 in the Southern Mountain (DU9) population. Other errors arising from the first distorted the number and trajectories of extant subpopulations. Instead of issuing the emergency order, the Minister entered into protracted negotiations with the province on recovery planning that continue at this writing. The nomenclatural ambiguity can be resolved by 1) using the currently accepted taxonomy naming Osborn’s caribou a valid subspecies, R. t. osborni, instead of Northern Mountain population of woodland caribou, 2) using original English names for Mountain caribou and Rocky Mountain caribou, and 3) basing conservation actions on these distinct phylogenetic units as per COSEWIC (2011, 2014).