Miracle-dz/UniFAR-FTUs huggingface dataset:
WHY AND HOW TO CAPTURE THE SEMANTICS OF WEB USER INTERFACES

Structured data on the Web has become very important over the last few years. Schema.org has proven to be the most recognized vocabulary for structuring data on the Web. However, most annotations using Schema.org's vocabulary describe exclusively content on websites. Today, these structured content data are mainly consumed by search engines to automatically browse websites with high speed and accuracy and to take over search efforts for humans. Annotated web user interfaces can hardly be found on websites or applications. Schema.org’s offered vocabulary to describe actions in a structured way plays a minor role on websites or applications and is mainly applied on rich emails. Also most structured data tools and platforms do not support the annotation of actions triggered via the user interface of a website or application. In this paper we motivate the importance of a semantic description of web user interfaces and present possible application areas to consume these structured data. Thereon, we investigate the suitability of Schema.org for the semantic enrichment of web user interfaces. Since there are hundreds of classes and properties in Schema.org, we present a conceptual model of Schema.org classes and properties suitable to annotate user interfaces of websites or applications. We also show to what extent interactive elements on HTML5 websites or applications can be automatically mapped to these model elements. As a proof of concept we introduce Schemator , our WYSIWYG tool to support the semantic enrichment process of web user interfaces. Schemator is not only a comfortable structured data tool but acts also as a SAAS platform to store and manage structured web interface data separated from the underlying websites and applications.
The occurrence of infective endocarditis with Staphylococcus lugdunensis bacteremia: A retrospective cohort study and systematic review

defined as at least 1 positive blood culture, admitted to Barnes-Jewish Hospital/Washington University from January 2006 to December 2014 • We identified 75 patients with SLB using the Barnes Medical Informatics Database, and excluded one patient because his chart was not available for review. • Demographic and clinical characteristics for the cohort were determined at the onset of bacteremia, which was defined as the date of the first positive blood culture • The Barnes-Jewish Hospital microbiology laboratory used the VersaTREK system for processing of blood cultures for the duration of this study. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) was the primary method of identifying bacteria from 2012 onward • IE was defined according to the 2000 Modified Duke Criteria. Severity of illness was assessed using the Pittsburgh bacteremia score (PBS) and systemic inflammatory response syndrome (SIRS) criteria • Descriptive statistics were used to describe the demographic and clinical characteristics of the study population. • Kaplan-Meier survival analyses and log-rank tests were used to determine differences in overall survival. Onset of bacteremia was defined as the date of the first positive blood culture, and censoring was performed on December 31, 2014. • Nonparametric bootstrapping methods consisting of random repeated sampling with replacement 1,000 times was performed to determine 95% confidence intervals (CI) for proportions of IE in patients with SLB • Systematic review of scientific literature was also performed. All original observational studies that determined the proportion of IE among patients with SLB The occurrence of infective endocarditis with Staphylococcus lugdunensis bacteremia: A retrospective cohort study and systematic review Lemuel R. Non, MD and Carlos A. Q. Santos, MD, MPHS
Sepsis-associated organ dysfunction and increased supportive care are associated with high serum interleukin-6 levels

Introduction: Detection of sepsis and septic shock is essential, since any delay in initiating a proper treatment is associated with a worse prognosis. Objective: To evaluate levels of interleukin-6 (IL-6) early in the onset of the evolution of sepsis associated-organ dysfunction and its relation to the need for more advanced supportive therapies. Methods: This is a prospective study at a 43-bed mixed Medical-surgical Intensive Care Unit (ICU) in a university hospital. Patients admitted to the ICU, over 18 years of age, with severe sepsis or septic shock and who presented the first organ dysfunction in less than 48 hours of admission to the ICU were included. We monitored in a daily basis the advanced supportive therapies, need for vasopressors, mechanical ventilation, or renal replacement therapy (RRT), until hospital discharge or death. Blood samples to measure the serum IL-6 levels were collected at the time of inclusion in the study, at 12 and 24 hours later. Patients were divided into two groups according to serum IL-6 levels at admission (Low IL-6: 1,000 pg/ml). Results: The need for norepinephrine was significantly higher in the group with High IL-6 (100%) than in the group with Low IL-6 (62.5%) (p = 0.009). RRT was also more frequent in patients with High IL-6 than in those with Low High IL-6 (87.5% vs. 55.5%, respectively, p = 0.056). Conclusion: These findings suggest that the evaluation of serum IL-6 level is useful in the early phase of the severe sepsis and septic shock in order to identify higher-risk patients.
The impact of alternative splicing on RNA subcellular localization

Background: Alternative splicing, a ubiquitous phenomenon in eukaryotes, provides a regulatory mechanism for the biological diversity of individual genes. Most studies have focused on the e↵ects of alternative splicing for protein synthesis. However, the influence of alternative splicing on the RNA subcellular localization has rarely been studied. Results: By analyzing RNA-seq data from subcellular fractions across thirteen human cell lines, we observed that splicing is apparent to promote cytoplasmic localization. We also discovered that intron retention is preferred by transcripts localized in the nucleus. Short and structurally stable introns show a positive correlation with nuclear localization. Such introns are predicted to be preferentially bound by MBNL1, an RNA-binding protein that contains two nuclear localization signals. Conclusions: Our findings reveal that alternative splicing plays an important role in regulating RNA subcellular localization. This study provides valuable clues for understanding the biological mechanisms of alternative splicing.
Korelasi kadar hepcidin dan asupan makanan dengan serum transferrin reseptor dan hemoglobin pada remaja stunted overweight

Background: Stunted overweight is associated with mild chronic inflammation. The state of inflammation will increase the expression of hepcidin, which affects the iron status of the body, besides the intake of protein, iron, and vitamin C. Objective: To analyze the correlation of hepcidin levels and food intake (protein, iron, vitamin C) with serum transferrin receptors (sTfR) and hemoglobin in stunted overweight adolescents. Method: The design of research was cross-sectional. The subjects were 64 adolescents stunted overweight aged 15-18 years in four high/vocational schools in the Banyumanik District, Semarang City. Measurement the level of hepcidin and sTfR was u sing the ELISA method and h a emoglobin was u sing Cyanomethemoglobin method. Data on protein, iron, vitamin C intake was u sing the SQ-FFQ method. Bivariate analysis was using Pearson and Spearman correlation test then followed by multiple linear regression analysis. Results: The result showed that 8 9.1% subjects had adequate intake of protein , 54.7% subjects had low intake of vitamin C, 76.6% subjects had low intake of iron. Hepcidin levels in all subjects were 100% normal. There were 7.8% s ubjects with a low sTfR and 7.8% with a low haemoglobin level. Stati s tic test showed there w as correlation between hepcidin with haemoglobin and sTfR (p 1 = 0,010 r 1 = -0,319, p 2 = 0,001, r 2 = 0,569). From food intake, only intake iron was correlated with haemoglobin but not with sTfR. There was significant difference between the mean of haemoglobin and sTfR among girls and boys. Further analysis, showed that only hepcidin was a weak negative determinant for sTfR (R 2 = 0,120). The determinant factors for haemoglobin were gender (p=0,001) and hepcidin (p =0,004) with the value of R 2 = 0,577. Conclusion: Hepcidin correlated with sTfR and haemoglobin while iron intake only correlated with hemoglobin.
Soft tissue reconstruction after lower extremity limb-sparing pediatric sarcoma resection

Aim: Limb salvage is the treatment of choice for lower extremity bone sarcomas in children. To date, peers have not described algorithms for soft tissue reconstruction of these defects. This paper is to report a large single center series of lower extremity salvage after sarcoma treatment, with algorithm. Methods: The authors performed a retrospective review of patients undergoing resection of lower extremity bone sarcomas at a single center over 12 years. Results: In total, 65 children (29 girls, 36 boys) with a mean age of 13 years (range 2.9-23.3 years) underwent resection of a lower leg sarcoma with limb-salvage. Tumors types included 50 osteosarcomas, and 15 Ewing sarcoma family of tumors. The types of reconstruction utilized included: 34 primary closures, 22 gastrocnemius and soleus flaps, 3 bipedicled flaps, 2 sural artery flaps, 1 pedicled anterolateral thigh flap, 3 pedicled posterior thigh flaps for subsequent above-knee amputations. No free flap based reconstructions were performed. An algorithm for reconstruction of leg defects in the setting of limb-salvage surgery is presented. Successful limb salvage rate was 95.4%. Limb salvage failed in 3 patients and they required amputation. Finally, 56 patients were able to ambulate without assistance at last follow-up. Conclusion: The authors present an algorithm for the reconstruction soft tissue after resection of lower extremity bone sarcomas. The use of these techniques helps to decrease complications and maximize function in children with these tumors. ABSTRACT
An Empirical Study on the Financial Competitiveness Evaluation System of Stock Exchange Listed SMEs of Gujarat, India

The purpose of this study is to identify the financial factors that enhance the financial competitiveness of small and medium enterprises (SMEs) in Gujarat, India. The principal component analysis has been applied to extract the financial factors from financial performance ratios of a sample size of 38 stock exchange SMEs, based in Gujarat, India. The ranking has been given to the SMEs based upon their factor score and comprehensive score. The results show that profitability, management efficiency, liquidity and leverage factors are the major factors affecting the financial competitiveness of SMEs. The study covers only one state of the country, and the findings from different states may differ and need to get verified. Despite the highest contribution of SMEs in the GDP of India, there exist very few Indian studies on SME competitiveness. This study contributes to filling this gap.
PTU-034 Expression of connective tissue growth factor by human intestinal myofibroblasts and effect of rho-kinase inhibition

Introduction Connective tissue growth factor (CTGF) has been implicated in the development of fibrosis in different organs, including stricture formation in Crohn's disease. As a profibrotic mediator, CTGF acts downstream and together with transforming growth factor β (TGF-β). Expression of TGF-β has previously been shown to be altered in myofibroblasts isolated from mucosal samples affected by inflammatory bowel disease. Rho-kinase is a downstream mediator of RhoA, a GTP-binding protein that is believed to regulate a number of myofibroblast functions. The aims of this study were to investigate (i) the expression of CTGF by human intestinal myofibroblasts isolated from mucosal samples obtained from different individuals and (ii) the effect of the Rho-kinase inhibitor Y-27632 on CTGF expression by intestinal myofibroblasts. Methods Myofibroblasts were isolated from normal colonic mucosal samples (obtained from operation resection specimens) and established in pure culture. Myofibroblasts were cultured in medium containing 0.1% or 10% fetal calf serum (FCS). CTGF transcript expression was studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and expression of protein (in cell lysates) by Western blot analysis. Following incubation with Y-27632 (final concentration 100 μM), changes in myofibroblast cell morphology, expression of CTGF and programmed cell death (analysis of the sub-G1 region of the cell cycle by flow cytometry) were studied. Results Studies by RT-PCR showed that when grown in 10% FCS, intestinal myofibroblast cultures from 5 mucosal tissue donors expressed CTGF transcript. Expression of CTGF protein was confirmed by western blot analysis of intestinal myofibroblasts grown in 10% FCS (n=7 donors). By contrast, when cultured in 0.1% FCS, only 2 out 5 donors expressed CTGF protein (0.1% FCS vs 10% FCS: p<0.03). Exposure to Y-27632 led to change in morphology to spindle-shaped cells, with all the myofibroblasts affected by 24 h. When cultured for 24 h with 10% FCS, Y-27632 led to a reduction in expression of CTGF protein by intestinal myofibroblasts isolated from 6 donors. However, there was no significant difference in the number of myofibroblasts undergoing programmed cell death between those cultured in medium only, compared to cells exposed to Y-27632 (events in sub-G1 region of cells cycle: 203.8 (SEM 51.62) vs 393.0 (64.91), p=0.10). Conclusion 1. Myofibroblasts isolated from normal human colonic mucosal samples are capable of expressing CTGF. 2. The Rho-kinase inhibitor Y-27632 reduces expression of CTGF protein by colonic myofibroblasts. 3. The Rho-kinase pathway may be a suitable therapeutic target in stricturing Crohn's disease.
The Relationship Between XRCC1 and XRCC6 Genes Polymorphisms and Renal Cell Carcinoma

The Relationship Between XRCC1 and XRCC6 Genes Polymorphisms and Renal Cell Carcinoma Sayed Alireza Mirsane, Shima Shafagh, and Sayed Mojtaba Mirsane Genetic Sciences Student and Researcher, Qom and Surgical Technologist, Kashan University of Medical Sciences, Kashan, IR Iran General Surgery Specialist, Medical School, Kashan University of Medical Sciences, Kashan, IR Iran Instructor of Education Office, Isfahan, IR Iran Corresponding author: Sayed Alireza Mirsane, Genetic Sciences Student and Researcher, Qom and Surgical Technologist, Kashan University of Medical Sciences, Kashan, IR Iran, E-mail: alireza.seyed70@gmail.com
Hydrogen detection using membrane-type surface stress sensor

This study shows a possibility of the application of a membrane-type surface stress sensor (MSS) with a Pd film to a hydrogen sensor. It was able to detect hydrogen concentrations from 5 to 40000 ppm in a nitrogen gas mixture. In the case of a conventional sensor using a hydrogen-occluding material, it is necessary to wait for a state of saturation. In contrast, the proposed method can detect hydrogen quickly by the initial rate of hydrogen absorption. The relationship between the initial absorption rate and hydrogen concentration is explained by considering the two-step reaction kinetics of hydrogen absorption into bulk Pd via Langmuir dissociative adsorption on surface.
Peptide arrays incubated with three collections of human sera from patients infected with mosquito-borne viruses

Global outbreaks and epidemics caused by emerging or re-emerging mosquito-borne viruses are becoming more common. These viruses belong to multiple genera including Flavivirus and Alphavirus and often cause non-specific or asymptomatic infection, which can confound viral prevalence studies. In addition, many acute phase diagnostic tests rely on the detection of viral components such as RNA or antigen. Standard serological tests are often not reliable for diagnosis after the acute phase due to cross-reactivity among viruses (e.g. flaviviruses). In order to contribute to development efforts for mosquito-borne serodiagnostics, we incubated 137 human sera on individual custom peptide arrays that consisted of over 866 unique peptides in quadruplicate. Our bioinformatics workflow to analyze these data incorporated machine learning, statistics, and B-cell epitope prediction. The unprocessed array data can be useful in separate meta-analyses that can be applicable to diverse efforts including the development of new pan-flavivirus antibodies, more accurate epitope mapping, and vaccine development against these viral pathogens.
Comparative Study of the In-Vitro Dissolution Profile of Griseofulvin Tablets Formulated with Kolliphor HS-15, Sodium Lauryl Sulphate and PEG 4000

the drug has resulted in high dosing of the drug even though it is prepared as micro-sized and ultra-micro sized particles. Abstract: Objective: Griseofulvin, an antifungal drug belongs to the class II of the Biopharmaceutical Classification System (BCS). It has the characteristics of poor aqueous solubility and good lipid permeability. Attempts have been made severally to improve the solubility and hence release of griseofulvin from different dosage forms. The study aimed to evaluate the effect of the different surfactants- Kolliphor® HS-15 (KHS 15), Sodium lauryl sulphate (SLS) and Polyethylene glycol (PEG) 4000 on the in-vitro dissolution and release of griseofulvin from compressed tablets. Method: Griseofulvin tablets were formulated with different concentrations of the surfactants and a control batch without surfactants using the wet granulation method. Dissolution test was carried out on the formulated tablets in 1000ml of 80% methanol. Comparisons were made amongst the dissolution profiles of the formulated tablets and a commercial brand using model dependent and independent methods. MANOVA was used in the analysis of percent drug release of the tablets. Result: All the different methods of comparing in-vitro dissolution are important. The tablets formulated with surfactants had better dissolution profiles than the control batch. Tablets containing PEG 4000 exhibited the best dissolution. The PEG 4000 containing tablet batches exhibited anomalous mechanism of drug release while the other batches of griseofulvin tablets including the commercial brand all exhibited quasi- Fickian mechanism of drug release. Conclusion: PEG 4000 containing tablets had the best dissolution profile. At the concentrations used, SLS and Kolliphor® HS 15 only had marginal improvement of griseofulvin dissolution compared with the control batch.
Assessment of the basal metabolic rate (BMR) with dual energy x-ray absorptiometry (DXA) in the management of the obese patient

Poster: "ESSR 2012 / P-0067 / Assessment of the basal metabolic rate (BMR) with dual energy x-ray absorptiometry (DXA) in the management of the obese patient" by: "F. Ponti, S. Brocchi, D. Diano, G. Peluso, E. Grillini, C. Sassi, G. Battista, A. Bazzocchi; Bologna/IT"
Evidence-Based Learning: Futures

With the introduction of learning design in early 2000 and learning analytics in 2012, the OU has led the way in how teachers make complex decisions to design interactive courses, and how students can maximise their learning potential. The next obvious steps would be to include AI, personalisation, and student-led learning analytics to provide learning opportunities that meet the unique needs of each learner, but whether this would be technically feasible and pedagogically desirable will be discussed. In this chapter we will look at recent and future developments concerning the “holy trinity” of learning design, learning analytics, and how teachers can help institutions like the OU to ensure that our current and future students’ needs are met. Furthermore, we will reflect on the affordances and limitations of learning design and learning analytics to help teachers to adapt their teaching and learning practices to meet learners’ needs.
DECREASED PAIN SCALE BASED ON CRITICAL PAIN OBSERVATION TOOL (CPOT) AND BEHAVIORAL PAIN SCALE NON-INTUBATED (BPS-NI) IN PATIENTS WITH REDUCED CONSCIOUSNESS BY CLASSICAL MUSIC INTERVENTION IN UNS HOSPITAL

Patient with reduced consciousness needs attention to their comfort as well as pain during treatment. Listening to classical music caused relaxation and pain reduction. This study aimed to determine the effect of classical music on the CPOT score, BPS-NI, and cortisol levels in patients with reduced consciousness. The research was conducted by using a pretest-posttest control group design. 18 patients were divided into the control group (C) and the classical music group (M). Classical music was played for 3 days respectively that consisted of 3 sessions per day. Furthermore, each patient was tested for cortisol levels on the third day. Comparative test of mean difference between pre-intervention and post-intervention obtained significant results in CPOT (p= 0.000) and BPS-NI (p= 0.001) measurements in all groups. Tukey's post-hoc test obtained significant results in which the M group had a lower mean score. The mean of cortisol level was higher in M group (14.7 μg/dL) compared to the C group (12.96 μg/dL), although not significant statistically (p= 0.67). Listening to classical music for patients with reduced consciousness decreased the pain scale. This was supported by the average of cortisol levels that were higher in the M group, considering that cortisol was a hormone that prevents pain.
Lower Socio-economic Status and Cardiovascular Disease: Role of Healthcare Facility and Policy in India

Background: Cardio-vascular disease (CVD) is one of the main cause of mortality Worldwide and India is no exception. Unlike developed countries, where both CVD prevalence and mortality has been established to affect lower socio-economic status (SES), in India there is no consensus among researchers over socio-economic patterning of CVD prevalence but the mortality rate has been reported to disproportionately affect the economically weaker sections. Aims & Objectives: This article, focuses at the issue of how lack of good healthcare facilities and non-supportive health policies are affecting CVD mortality positively among lower SES of India. Challenges of the Indian healthcare system in context of lower SES can be described in terms of the issue of availability, accessibility and affordability. Inadequate policy and public healthcare system either leads to the problem of high Out-of-Pocket Payments (OPP) or opting out of the treatment, which further increases poverty and mortality among them. Moreover, limited insurance coverage and inadequate regulatory policies for alcohol and tobacco-leading CVD risk factors among lower SES groups – do little to discourage its use among them. Conclusion: Since, lower SES people in India are already under the burden of communicable diseases, government should take immediate steps to control the mortality among them by creating a supportive environment through pro-poor health policies and healthcare facilities.