Miracle-dz/UniFAR-FTUs huggingface dataset:
AB0153 Effect and Mechanism of Intestinal Clostridium on the Development of Rheumatoid Arthritis

Background The study evaluated the relationship between conditioned pathogen clostridium and rheumatoid arthritis (RA) using collagen-induced arthritis (CIA) animal model. Methods SPF DBA/1 mice were randomly divided into 4 groups (n=6). Enema administration of clostridium which were from RA patients was started on 2 weeks before injection of the II collagen in Mouse and lasted for 5 weeks. Mouse was sacrificed 13 weeks after injection of the II collagen. Serum level of TNF-α, IL-1β and IL-23 were observed, and four-point arthritis indexes were also assessed. Knee joints were assessed according to the histopathology. Results Arthritis incidence, the number of arthritic limbs per arthritic mouse and the arthritic severity scores were higher in CIA-Clostridium group than the CIA group after the 13 weeks of the immunization, however, the difference was not statistically significant (P>0.05). As compared with the CIA (TNF-α: 239.7±59.9pg/ml, IL-1β: 190.0±55.0pg/ml), the TNF-α: (301.1±19.2pg/ml, P <0.01) and IL-1β (247.2±32.0pg/ml, P<0.05) were significantly increased. Conclusions Present research suggests that Clostridium may not induce the arthritis directly. Enema administration of Clostridium may have effect on the disease, but the effect was not statistically significant. Clostridium vaccination combining collagen-induced could significantly increase the level of cytokines in peripheral blood of CIA mice, such as TNF-αand IL-1β. References Vaahtovuo, J., et al., Fecal microbiota in early rheumatoid arthritis. J Rheumatol, 2008. 35(8): p. 1500-5. Brand, D.D. , K.A. Latham, and E.F. Rosloniec, Collagen-induced arthritis. Nat Protoc, 2007. 2(5): p. 1269-75. van de Loo, F.A. , et al., Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum, 1995. 38(2): p. 164-72. Zhang, F. , G. Meng, and W. Strober, Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol, 2008. 9(11): p. 1297-306. Cua, D.J., et al., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature, 2003. 421(6924): p. 744-8. Murphy, C.A. , et al., Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med, 2003. 198(12): p. 1951-7. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.1094
ORGANIZATIONAL CULTURE AS MATRIX OF CORPORATE ETHICS

Multiculturalism is now one of the greatest challenges in the Western society. It supposes a deeper awareness of the various cultures involved in a given society. Of course, the well‐known cultural and ethnic groups must basically be involved in such a social change. But, since the arising and growth of business ethics as a field of research, the business world as a social institution has revealed itself as a complex network of subcultures. So, the “organizational culture” has become an “a priori concept” in business ethics. Although many researches deal with corporate culture, very few authors emphasize its structural elements. A systemic view of the organizational culture expresses how we cannot develop a corporate ethics without at least a “fore‐understanding” or, at best, a critical judgment on the organizational culture of a given corporation. I will describe the four subsystems of the organizational culture and their ethical implications.
The Hemodynamic Mechanism of Pounding in the Neck in Atrioventricular Nodal Reentrant Tachycardia

ALTHOUGH the diagnosis of atrioventricular nodal reentrant tachycardia is made on the basis of electrophysiologic criteria, the symptoms and results of physical examination in patients with this arrhythmia may differ from those in patients with other forms of supraventricular tachycardia.1 2 3 4 The present study suggests that among patients with supraventricular tachycardia, only those with atrioventricular nodal reentrant tachycardia feel pounding in the neck during the arrhythmia. They also have higher right atrial pressures and more pronounced reversal of flow in the superior and inferior vena cava during atrial systole than patients with other forms of supraventricular tachycardia. The feeling of regular, .
Hsp90 Inhibitors are Promising Radiosensitizers for Radiotherapy

Heat shock protein 90(Hsp90)is an ATP-dependent molecular chaperone protein.The Hsp90 superchaperone complex assists folding and function of a variety of client proteins.Many oncoproteins are Hsp90 client proteins.Compared to normal cels,tumor cels require higher Hsp90 chaperone activity;therefore,targeting Hsp90 with chemical inhibitors disrupts multiple oncogenic processes and has potent antitumor activity.Many Hsp90 inhibitors are currently being tested in preclinical or clinical trials.This review summarizes published data concerning radiosensitization of human tumor cels in in vitro and in vivo tumor models with Hsp90 inhibitors.
Apps for Asthma: Design suggestions after first-hand experiences using available asthma self-management applications by teens and their healthcare provider

6. Panzera, A.D., Schneider, T. , Martinasek, M. , Bryant, C.A. , Lindenberger, J. & McDermott, R.J. (2013). Adolescent Asthma Self-Management: Patient and Parent Caregiver Perspectives on Using Social Media to Improve Care. Unpublished manuscript. Apps for Asthma: Design suggestions after first-hand experiences using available asthma self-management applications by teens and their healthcare provider Tali Schneider, MPH, CHES, Anthony Dominic Panzera, MPH Social Marketing Group Florida Prevention Research Center University of South Florida College of Public Health
Monitoring training loads in elite tennis DOI:10.5007/1980-0037.2010v12n3p217

Training load (TL) is influenced by both training volume and training intensity. A precise understanding of the TLs completed during training is crucial to achieve desirable training outcomes and to avoid overtraining. TL can be monitored in many different ways; however, we recommend the session-rate of perceived exertion (session-RPE) method for quantifying TL because of its low cost and because it is easy to understand and relatively simple to implement. In this report, we provide data regarding TLs collected during the 2008 Roland Garros Tournament. Our experience in tennis suggests the session-RPE method to be a valuable tool that can be used to control training and to avoid excessive TLs. We also believe that accurate monitoring of TL will enable the coach to better understand of the sports training process, ultimately leading to the improvement of performance.
Influence of Daotan Decoction on the Expression of ICAM-1 in Cerebrovascular Endothelial Cells of Rat

Objective To study the intervention of Daotan Decoction to the expression of ICAM-1 in cerebrovascular endothelial cells. Methods Cerebrovascular endothelial cells were cultured to observed the influence of ICAM-1 expression,which was induced by TNF-α,by the way of immunocytochemistry methods. Results Compared with control group,the expression of ICAM-1 in model group was time-dependent (P0.05). And compared with model group,Daotan Decoction could significantly restrain ICAM-1 expression (P 0.05). Conclusion Daotan Decoction could restrain ICAM-1 expression induced by TNF-α in different phase.
A Fully Non-Metallic Gas Turbine Engine Enabled by Additive Manufacturing Part I: System Analysis, Component Identification, Additive Manufacturing, and Testing of Polymer Composites

The research and development activities reported in this publication were carried out under NASA Aeronautics Research Institute (NARI) funded project entitled "A Fully Nonmetallic Gas Turbine Engine Enabled by Additive Manufacturing. " The objective of the project was to conduct evaluation of emerging materials and manufacturing technologies that will enable fully nonmetallic gas turbine engines. The results of the activities are described in three part report. The first part of the report contains the data and analysis of engine system trade studies, which were carried out to estimate reduction in engine emissions and fuel burn enabled due to advanced materials and manufacturing processes. A number of key engine components were identified in which advanced materials and additive manufacturing processes would provide the most significant benefits to engine operation. The technical scope of activities included an assessment of the feasibility of using additive manufacturing technologies to fabricate gas turbine engine components from polymer and ceramic matrix composites, which were accomplished by fabricating prototype engine components and testing them in simulated engine operating conditions. The manufacturing process parameters were developed and optimized for polymer and ceramic composites (described in detail in the second and third part of the report). A number of prototype components (inlet guide vane (IGV), acoustic liners, engine access door) were additively manufactured using high temperature polymer materials. Ceramic matrix composite components included turbine nozzle components. In addition, IGVs and acoustic liners were tested in simulated engine conditions in test rigs. The test results are reported and discussed in detail.
Forskningsrefleksioner over Dansk Turismes Mange Udfordringer

Det her anlagte perspektiv på dansk turismes mange udfordringer beror på turismeforskning, undervisning og kompetenceudvikling i det danske turisterhverv gennem de seneste to årtier. Artiklen giver et overblik over centrale udfordringer for dansk turisme, og sætter samtidig rammen for denne særudgave. Som socialt og økonomisk fænomen undersøges turisme som multidisciplinært forskningsfelt for at afdække dets økonomiske og udviklingsmæssige vækstpotentiale; policy; innovation; marketing, motivation og betydning; som performance og transformation; som udtryk for, og resultat af globalisering; og som middel til en mere bæredygtig udvikling. Artiklen påpeger afstanden mellem de, der skaber viden og de der bruger viden (f.eks politikere og turisterhvervet), som skal mindskes for at kunne understøtte en strategisk og mere bæredygtig turismeudvikling. Artiklen konkluderer, at der er behov for nye samarbejdsrelationer, kritisk refleksion og politisk vision for at omsætte de mange udfordringer til muligheder, hvilket ultimativt må adressere hvilken form for turisme vi ønsker at have i Danmark.
Black Fever among the Ethnic Santal People in Bangladesh

The study tries to find out the scenario of black fever among the Santal people in Bangladesh. Santal patient health seeking behaviors related with their community people decision, free treatment consideration, preferable healthcare option. Those the entire thing is related with culture. The study is explorative and to some extent descriptive in nature that enforces to adopt mixed with qualitative and quantitative data as well as secondary and primary data. Research shows that 81% patient depend too much on treatment of indigenous physician (Kabiraj). Also barriers of accessing health care are the prevailing factor for health seeking behavior. 92% respondents said awareness and knowledge regarding black fever has too much impact. 43% people are influenced by church and Non-Governmental Organization (N.G.O) during decision making regarding treatment. 54% patients state that, skin turns into more black after taking medicine. Economic condition of lower class people has too much impact on health seeking behavior also. Santal people traditional practice is responsible attacked by black fever. If we will able to conscious ethnic people, dying and suffering regarding black fever will dissolve.
Medical Comorbidity is Associated with Persistent Index Hip Pain after Primary THA

Objective— To characterize whether medical comorbidity predicts persistent moderate-severe pain after total hip arthroplasty (THA) Methods— We analyzed the prospectively collected data from the Mayo Clinic Total Joint Registry for patients who underwent primary or revision THA between 1993–2005. Using multivariable-adjusted logistic regression analyses, we examined whether certain medical comorbidities were associated with persistent moderate-severe hip pain 2- or 5-years after primary or revision THA. Odds ratios (OR), along with 95% confidence intervals (CI) and p-value are presented. Results— The primary THA cohort consisted of 5,707 THAs and 3,289 THAs at 2- and 5-years, and revision THA, 2,687 and 1,627 THAs, respectively. In multivariable-adjusted logistic regression models, in the primary THA cohort, renal disease was associated with lower odds of moderate-severe hip pain (OR, 0.6; 95% CI, 0.3, 1.0) at 2-years. None of the comorbidities were significantly associated at 5-years. In the revision THA cohort, heart disease was significantly associated with higher risk (OR, 1.7; 95% CI, 1.1, 2.6) at 2-years and connective tissue disease with lower risk (OR, 0.5; 95% CI, 0.3, 0.9) of moderate-severe hip pain at 5-years follow-up. Conclusion— This study identified new correlates of moderate-severe hip pain after primary or revision THA, a much-feared outcome of hip arthroplasty. Patients with these comorbidities should be informed regarding the increased risk or moderate-severe index hip pain, so that they can have a fully informed consent and realistic expectations.
Spinal anestezi altinda yapilan lomber disk cerrahilerinin retrospektif değerlendirmesi Retrospective evaluation of outcomes in lumbar disc surgery with spinal anesthesia

Objective: We investigated feasibility, possible advantages and disadvantages of spinal anesthesia in lomber disc surgery. Methods: We retrospectively analyzed a total of 100 patients operated for elective lomber spinal surgery under spinal anesthesia. Results: Spinal anesthesia was sufficient for lumbar disc surgery in 97 of 100 patients. Three patients received general anesthesia due to insufficient spinal block. Aller gic reaction was observed in one patient receiving general anesthesia, and treated with intravenous steroid and antihistaminic drugs. We observed bradycardia and hypotension necessitating ephedrine administration in eight patients, post dural puncture headache in 10 patients (two patients were discharged at 4 and 7 days later therefore), who received spinal anesthesia. Following spinal anesthesia, patients required first analgesic at 10th hour. Patients receiving general anesthesia demanded first an algesic in the post operative care unit. Conclusion: We are of the opinion that spinal anesthesia may be safely used in lumbar disc surgeries, provided that patients are not positioned until sufficient anxiolytic and spinal block are established. J Clin Exp Invest 2014; 5 (1): 54-58 Key word: Spinal anesthesia, spinal surgery, intraoperative complications, postoperative pain OZET Amac: Lomber disk cerrahisinde spinal anestezinin uygu
WORKSITE HEALTH PROMOTION

INTRODUCTION Socioeconomic factors are powerful determinants of health. Current discourse abounds with references to addressing social determinants of health to improve the health and well-being of people and populations. Certainly, from a worksite health promotion perspective, social determinants of health play an important part in the health, well-being, and functional status of employees. In fact, in early 2010, we wrote a column in ACSM’s Health & Fitness Journal on exactly this topic (1). We considered a “causal chain” of determinants of premature deaths and highlighted how social determinants of health relate to health behaviors, biological markers, diagnosed disease, and premature death (see Figure 1). Biological markers included the early indicators (or signal events) for subsequent disease diagnoses, the topic of our earlier column on the 2018 Physical Activity Guidelines for Americans (2). This time, we consider the relationship between physical activity and the upstream social determinants of health themselves among members of the workforce.
Creating and purifying an observation instrument using the generalizability theory

Abstract The control of quality of data it is one of the most relevant aspects in observational researches. The Generalizability Theory (GT) provides a method of analysis that allows us to isolate the various sources of error measurement. At the same time, it helps us to determine the extent to which various factors can change and analyze the effect on the generalizability coefficient. In the work shown here, there are two studies aimed to creating and purifying an observation instrument, Observation Protocol in the Teaching Functions (Protocolo de Funciones Docentes, PROFUNDO, v1 and v2), for behavioral assessment which has been carried out by instructors in a social-affective out-of-school program. The reliability and homogeneity studies are carried out once the instrument has been created and purified. The reliability study will be done through the GT method taking both codes (c) and agents (a) as differential facets in. The generalization will be done through observers using a crossed multi-faceted design (A × O × C). In the homogeneity study the generalization facet will be done through codes using the same design that the reliability study.
PERDA NO VALOR RECUPERÁVEL DE ATIVOS: FATORES EXPLICATIVOS DO NÍVEL DE EVIDENCIAÇÃO DAS EMPRESAS DE CAPITAL ABERTO BRASILEIRAS

This work aims to identify significant factors that explain the level of disclosure of the loss in the recoverable value of assets in public companies in Brazil. To measure the level of disclosure we calculated an index of disclosure based on five metrics drawn from the disclosure requirements contained in the statement CPC-01. The data for calculating rates were obtained through content analysis in the footnotes and Statement of Income of companies. After calculating the disclosure index (that is the dependent variable in this study), we employed a multiple linear regression model to test six hypotheses formed based on the following independent variables: size, profitability, audit firm, corporate governance, internationalization and debt. The results show that, on average, larger firms audited by Big Four tend to have a higher level of adequacy to the disclosure requirements of the CPC-01, and at the significance level of 10% firms with larger debt index and a differentiated level of corporate governance, on average, to have a greater level of adequacy to disclosure requirements issued by the CPC-01.
On the problem of detecting effects of lifestyle on cognitive change in adulthood: Reply to Pushkar et al. (1999).

The authors respond to issues raised about data from the Victoria Longitudinal Study and further explain concerns regarding evidence for the engagement hypothesis. Discussion focuses on the use of social stratification variables such as occupational prestige and educational attainment as measures of an engaged lifestyle. It is argued that (a) tests of the hypothesis should focus on the relationship of behavior and activities thought to be proximal beneficial influences on adult cognitive development: (b) persuasive evidence for engagement effects from existing data require demonstration of effects of intellectual activities that are statistically independent of associations of social status with intellectual and cognitive development; and (c) currently available longitudinal data do not provide definitive evidence regarding the benefits of an engaged lifestyle on cognitive change.
As experiências de consumo na perspectiva da teoria da cultura do consumo: identificando possíveis interlocuções e propondo uma agenda de pesquisa

The question that this essay addresses is the established fact that consumer research needs to incorporate into its analysis elements of the notion of experiential consumption and the perception that Brazilian researchers have ignored a number of subjects that lead to a better understanding of the acts of consumption, their subjects and cultural contexts. Therefore, the main objective here is to discuss a proposal for dialogue between the literature of consumer culture and discussions arising from the notion of experiential consumption by emerging research issues and propose methodological alternatives to the understanding of consumer experiences with a perspective of consumer culture. The conclusion is that it is not only possible, but also highly desirable, to establish rich and fruitful discussions about the possibilities of dialogue between these fields and propose new epistemologies and methodologies that contribute to a perspective that encompasses the understanding of the demand for both experiential and a cultural phenomenon approaches.
A Survey on Knowledge, Attitude, Belief and Practice related to HIV/AIDS among MSM

Objective To understand the MSM' s(men who have sex with men) knowledge, attitude, belief and practice (KABP) related to HIV/AIDS. Methods MSM volunteers were trained and sent to bars, parks and massage parlors to conduct KABP survey, distribute health education materials and provide anonymous HIV testing. Results Multiple sex partners were common among MSM. 36.9% of MSM had regular partners, while 53.8% had sexual contact with women.The rate of consistent condom use for active oral, passive oral, insertive anal, and receptive anal sexs were 6.2%,6.5%, 30.9% and 40.5 % , respectively. 23.8 % of MSM stated STD symptoms. 40.4 % of MSM did not consider them at the risk of HIV infection; 78.6 % gave right answers about HIV transmission routes, but only 36.9 % to 65.5 % did so about other STD and HIV/ AIDS knowledge. Eleven( 13.84 %) MSM took HIV test with one being positive. Conclusion Multiple sex partners and unprotected sex have put MSM at the risk of STD and HIV/AIDS.
Double-Row, Transosseous-Equivalent Suture-Bridge Repair for Supraspinatus Tears: Power Up the Healing

Arthroscopic rotator cuff repair is one of the most commonly performed surgeries in orthopedics. The primary goal of this procedure is to reduce shoulder pain and restore its function so that patients may return to some of their preinjury activities. Arthroscopic double-row transosseous-equivalent or suture-bridge repair techniques have become increasingly popular over the last decade. This repair technique, which uses 2 rows of suture anchors to recreate a biomechanically favorable healing environment at the anatomic footprint of the rotator cuff, produces a strong fixation construct with improved tendon-to-bone contact and compression over the anatomic footprint. The addition of this technique to one’s armamentarium has the potential to lead to improved patient outcomes after rotator cuff repair. In this review, we will detail some of the technical pearls on how to perform a double-row transosseous-equivalent repair and power up the healing of rotator cuff tears involving the supraspinatus.
A Case Study of Organizational Stress in Elite Sport

This paper is an investigation of organizational stress in elite athletes. Fifteen elite athletes from the UK were interviewed with regard to potential sources of organizational stress in preparation for major international competitions. Four main organizational stress issues were examined: environmental issues, personal issues, leadership issues, and team issues. The main environmental issues that were revealed were: selection, the training environment, and finances. The main personal issues were: nutrition, injury, and goals and expectations. The main leadership issues revealed were: coaches, and coaching styles. The main team issues were: team atmosphere, support network, roles, and communication. The results are presented largely in the form of direct quotes to convey the intricate nature of the issues. The results are discussed in terms of the important practical and theoretical implications of organizational stress in elite sport, particularly for those researchers and practitioners who wish to gain a better understanding of elite performers as they prepare for major international competitions. Also, some possible strategies for coping with organizational stress in elite sport are discussed.