Miracle-dz/UniFAR-FTUs huggingface dataset:
Membranoproliferative glomerulonephritis and C3 glomerulopathy in children: change in treatment modality? A report of a case series

Abstract Background Membranoproliferative glomerulonephritis (MPGN) with immune complexes and C3 glomerulopathy (C3G) in children are rare and have a variable outcome, with some patients progressing to end-stage renal disease (ESRD). Mutations in genes encoding regulatory proteins of the alternative complement pathway and of complement C3 (C3) have been identified as concausative factors. Methods Three children with MPGN type I, four with C3G, i.e. three with C3 glomerulonephritis (C3GN) and one with dense deposit disease (DDD), were followed. Clinical, autoimmune data, histological characteristics, estimated glomerular filtration rate (eGFR), proteinuria, serum C3, genetic and biochemical analysis were assessed. Results The median age at onset was 7.3 years and the median eGFR was 72 mL/min/1.73 m2. Six children had marked proteinuria. All were treated with renin–angiotensin–aldosterone system (RAAS) blockers. Three were given one or more immunosuppressive drugs and two eculizumab. At the last median follow-up of 9 years after diagnosis, three children had normal eGFR and no or mild proteinuria on RAAS blockers only. Among four patients without remission of proteinuria, genetic analysis revealed mutations in complement regulator proteins of the alternative pathway. None of the three patients with immunosuppressive treatment achieved partial or complete remission of proteinuria and two progressed to ESRD and renal transplantation. Two patients treated with eculizumab revealed relevant decreases in proteinuria. Conclusions In children with MPGN type I and C3G, the outcomes of renal function and response to treatment modality show great variability independent from histological diagnosis at disease onset. In case of severe clinical presentation at disease onset, early genetic and biochemical analysis of the alternative pathway dysregulation is recommended. Treatment with eculizumab appears to be an option to slow disease progression in single cases.
Pre- and postoperative headache in patients with meningioma

Background Meningiomas are generally slowly growing intracranial tumors. They are often incidentally diagnosed, given that symptoms may be absent even in cases of an enormous tumor size. Headache is a frequent but not consistent symptom. Therefore, we examined the association between structural, biochemical and histochemical tumor parameters with preoperative as well as postoperative occurrence of headache. Methods In our study, we prospectively investigated 69 consecutive patients enrolled for meningioma neurosurgery. Anatomical, histological and biochemical parameters were acquired, and headache parameters were registered from the clinical report and from a questionnaire filled by the patients before neurosurgery. The headache was re-evaluated one year after neurosurgery. The study was designed to exploratively investigate whether there is an association of acquired clinical and biological parameters with the occurrence of preoperative and postoperative headache. Results Edema diameter and the proliferation marker MIB-1 were negatively associated with the incidence and intensity of preoperative headache, while the content of prostaglandin E2 in the tumor tissue was positively associated with preoperative headache intensity. Headache was more prevalent when the meningioma was located in the area supplied by the ophthalmic trigeminal branch. Compared to preoperative headache levels, an overall reduction was observed one year postoperative, and patients with a larger tumor had a higher headache remission. In parietal and occipital meningiomas and in those with a larger edema, the percentage of the headache remission rate was higher compared to other locations or smaller edema. Multivariable analyses showed an involvement of substance P and prostaglandin E2 in preoperative headache. Conclusions The study demonstrates new associations between meningiomas and headache. The postoperative headache outcome in the presented patient sample is encouraging for the performed neurosurgical intervention. These results should be tested in a prospective study that incorporates all patients with meningiomas.
Extraction of templates from phrases using Sequence Binary Decision Diagrams

Abstract The extraction of templates such as ‘regard X as Y’ from a set of related phrases requires the identification of their internal structures. This paper presents an unsupervised approach for extracting templates on-the-fly from only tagged text by using a novel relaxed variant of the Sequence Binary Decision Diagram (SeqBDD). A SeqBDD can compress a set of sequences into a graphical structure equivalent to a minimal deterministic finite state automata, but more compact and better suited to the task of template extraction. The main contribution of this paper is a relaxed form of the SeqBDD construction algorithm that enables it to form general representations from a small amount of data. The process of compression of shared structures in the text during Relaxed SeqBDD construction, naturally induces the templates we wish to extract. Experiments show that the method is capable of high-quality extraction on tasks based on verb+preposition templates from corpora and phrasal templates from short messages from social media.
Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages)

Diabetic patients exhibit serum AGE accumulation, which is associated with reactive oxygen species (ROS) production and diabetic cardiomyopathy. ROS-induced PKCδ activation is linked to mitochondrial dysfunction in human cells. However, the role of PKCδ in cardiac and mitochondrial dysfunction caused by AGE in diabetes is still unclear. AGE-BSA-treated cardiac cells showed dose- and time-dependent cell apoptosis, ROS generation, and selective PKCδ activation, which were reversed by NAC and rotenone. Similar tendency was also observed in diabetic and obese animal hearts. Furthermore, enhanced apoptosis and reduced survival signaling by AGE-BSA or PKCδ-WT transfection were reversed by kinase-deficient (KD) of PKCδ transfection or PKCδ inhibitor, respectively, indicating that AGE-BSA-induced cardiomyocyte death is PKCδ-dependent. Increased levels of mitochondrial mass as well as mitochondrial fission by AGE-BSA or PKCδ activator were reduced by rottlerin, siPKCδ or KD transfection, indicating that the AGE-BSA-induced mitochondrial damage is PKCδ-dependent. Using super-resolution microscopy, we confirmed that PKCδ colocalized with mitochondria. Interestingly, the mitochondrial functional analysis by Seahorse XF-24 flux analyzer showed similar results. Our findings indicated that cardiac PKCδ activation mediates AGE-BSA-induced cardiomyocyte apoptosis via ROS production and may play a key role in the development of cardiac mitochondrial dysfunction in rats with diabetes and obesity.
Child-adult differences in neuromuscular fatigue are muscle-dependent.

The aim of this study was to compare the development and etiology of neuromuscular fatigue of the knee extensor (KE) and plantar flexor (PF) muscles during repeated maximal voluntary isometric contractions (MVIC) between children and adults. Twenty-one prepubertal boys (9-11 years) and 24 men (18-30 years) performed two fatigue protocols consisting in a repetition of 5-s isometric MVIC of the KE or PF muscles interspersed with 5-s passive recovery periods until MVIC reached 60% of its initial value. The etiology of neuromuscular fatigue of the KE and PF muscles was investigated by means of non-invasive methods such as the surface electromyography, single and doublet magnetic stimulation, twitch interpolation technique and NIRS. The number of repetitions performed was significantly lower in men (15.4 ± 3.8) than boys (38.7 ± 18.8) for the KE fatigue test. In contrast, no significant difference was found for the PF muscles between boys and men (12.1 ± 4.9 and 13.8 ± 4.9 repetitions, respectively). Boys displayed a lower reduction in potentiated twitch torque, low-frequency fatigue and muscle oxygenation than men whatever the muscle group considered. In contrast, voluntary activation level and normalized EMG data decreased to a greater extent in boys than men for both muscle groups. To conclude, boys experienced less peripheral and more central fatigue during repeated MVICs than men whatever the muscle group considered. However, child-adult differences in neuromuscular fatigue were muscle-dependent since boys fatigued similarly to men with the PF muscles and to a lower extent with the KE muscles than men.
Anti-NMDAR Encephalitis in a 13-Year-Old Female: A 24-Month Clinical Follow-Up

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare autoimmune disorder manifesting as seizures, movement disorders, and psychiatric changes. However, there have been few case reports concerning this disorder in South Korean children. The current case report describes a pediatric patient with anti-NMDAR encephalitis. A 13-year-old female patient developed clonic movements of the right arm followed by aphasia, paresthesia, and right-sided hemiparesis. The electroencephalogram (EEG) results indicated electroclinical seizures arising from the left temporal area. Brain magnetic resonance imaging (MRI) revealed high signal intensity and cortical swelling in left temporal lobe. Anti-NMDAR antibodies were detected in the cerebrospinal fluid (CSF). The patient was treated with intravenous immunoglobulin and high-dose methylprednisolone and showed partial improvement in language skills, paresthesia, and motor power. The brain MRI and EEG results also indicated improvement. However, anti-NMDAR antibodies persisted in the CSF. After four doses of rituximab, the patient exhibited complete recovery of language and motor skills, and was seizure free under treatment with antiepileptic medication. There were no residual anti-NMDAR antibodies in the CSF at her 24-month follow-up visit. This case report elucidates the benefits of early intervention using rituximab to improve neurological deficits and achieve baseline recovery in patients with anti-NMDAR encephalitis.
Impact of performance status and transfusion dependency on outcome of patients with myelodysplastic syndrome, acute myeloid leukemia and chronic myelomonocytic leukemia treated with azacitidine (PIAZA study)

Azacitidine (Vidaza®) is the standard treatment for patients with higher‐risk myelodysplastic syndromes (MDS) not eligible for allogeneic stem cell transplantation. In the noninterventional study PIAZA, we evaluated the effectiveness and safety of azacitidine treatment in 149 patients with higher‐risk MDS, chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) in routine clinical practice.
Monolingual and Cross-lingual Information Retrieval in Cultural Microblog at CLEF 2018

For CLEF 2018, we focus on cultural microblog search. The aim of this work is to find relevant microcritics in a monolingual and cross lingual context about films. This task is challenging due to the short length of the query and of the documents. For the monolingual context we propose to expand the query using a probalistic weighting scheme. For the french-english cross language task, we used a state of the art approach based on query transation.
PIVETed-Granite: Computational Phenotypes through Constrained Tensor Factorization

It has been recently shown that sparse, nonnegative tensor factorization of multi-modal electronic health record data is a promising approach to high-throughput computational phenotyping. However, such approaches typically do not leverage available domain knowledge while extracting the phenotypes; hence, some of the suggested phenotypes may not map well to clinical concepts or may be very similar to other suggested phenotypes. To address these issues, we present a novel, automatic approach called PIVETed-Granite that mines existing biomedical literature (PubMed) to obtain cannot-link constraints that are then used as side-information during a tensor-factorization based computational phenotyping process. The resulting improvements are clearly observed in experiments using a large dataset from VUMC to identify phenotypes for hypertensive patients.
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells

Climbing fibers (CFs) provide instructive signals driving cerebellar learning. However, conflicting experimental studies have been reported about the reliability of CF mediated Ca2+ influx in Purkinje cell (PC) distal dendrites. Mechanisms causing the wide variation in duration and spikelet numbers of complex spikes (CSs) have not been explored systematically. Using a new experimentally validated PC model, we describe the full range of modifiability of CF responses to explain the experimental data and make new predictions. We find voltage state gates the initiation and propagation of dendritic spikes. PC dendrites exhibit inhomogeneous excitability with individual branches as computational units for CF input. Somatic CSs are regulated by voltage state, CF activation phase and instantaneous CF firing rate. Concurrent synaptic inputs can affect CSs by modulating dendritic responses in a spatially precise way. These voltage- and branch-specific CF responses will increase dendritic computational capacity and give PCs an active role in integrating CF signals.
Organizing Health Care Networks: Balancing Markets, Government and Civil Society

Much is changing in health care organization today. A perspective or paradigm that is gaining ever increasing momentum is that of translational, extramural and integrated care. Current research suggests many potential benefits for integrated care and health care networks but the ethical issues are less frequently emphasized. Showing that integrated care can be beneficial, does not mean it is automatically ethically justified. We will argue for three ethical requirements such health care networks should meet. Subsequently we will look at the mechanisms driving the formation of networks and examine how these can cause networks to meet or fail to meet these ethical requirements or obligations. The three mechanisms we will examine are government, civil society and market mechanisms, which, we argue, should be balanced properly. Each mechanism is able to provide a relevant ethical perspective to health care networks. However, when the balance is skewed towards a single mechanism, health care networks might fail to promote one or more of the ethical requirements.
Incorporating fossils into the Pinaceae tree of life.

PREMISE OF THE STUDY Pinaceae have a rich but enigmatic early fossil record, much of which is represented by permineralized seed cones. Our incomplete knowledge of morphology and anatomy in living and extinct species poses an important barrier to understanding their phylogenetic relationships and timing of diversification. METHODS We expanded a morphology matrix to 46 fossil and 31 extant Pinaceae species, mainly adding characters from stem and leaf anatomy and seed cones. Using parsimony and Bayesian inference, we compared phylogenetic relationships for extant taxa with and without fossils from the morphology matrix combined with an alignment of plastid gene sequences. KEY RESULTS Combined analysis of morphological and molecular characters resulted in a phylogeny of extant Pinaceae that was robust at all nodes except those relating to the interrelationships of Pinus, Picea, and Cathaya and the position of Cedrus. Simultaneous analysis of all fossil and extant species did not result in changes in the relationships among the extant species but did greatly reduce branch support. We found that the placement of most fossils was sensitive to the method of phylogenetic reconstruction when analyzing them singly with the extant species. CONCLUSIONS A robust phylogenetic hypothesis for the main lineages of Pinaceae is emerging. Most Early Cretaceous fossils are stem or crown lineages of Pinus, but close relationships also were found between fossils and several other extant genera. The phylogenetic position of fossils broadly supports the existence of extant genera in the Lower Cretaceous.
Challenges in Taking Sexual History: A Qualitative Study of Indian Postgraduate Psychiatry Trainees

Context: In India, psychiatrist is an important point of helpseeking for sexual complaints. A detailed sexual history can go a long way in understanding sexual difficulties. In this background, there is inadequate information on the difficulties that psychiatry postgraduate trainees experience while taking a sexual history as part of a routine mental health evaluation. Aims: The aim was to study the difficulties experienced by postgraduate psychiatry trainees while taking sexual history as a part of routine mental health evaluation. Setting: This study was conducted in an Indian medical college general hospital psychiatry setting. Materials and Methods: This is a qualitative study using focus group discussions and in-depth interviews with postgraduate psychiatry trainees. Statistical Analysis: Content analysis was used to identify direct and latent themes. Results: Thematic saturation was achieved with 17 participants. Major themes of difficulties that emerged included trainee-related factors such as gender and sociocultural background of the trainee; patient-related factors such as age, gender, and sexual orientation; setting-related factors; and language-related difficulties. Conclusions: Specific and regular training in taking a sexual history is essential in addressing the difficulties faced by postgraduate psychiatry trainees in India.
WBI at CLEF eHealth 2018 Task 1: Language-independent ICD-10 Coding using Multi-lingual Embeddings and Recurrent Neural Networks

This paper describes the participation of the WBI team in the CLEF eHealth 2018 shared task 1 (“Multilingual Information Extraction ICD-10 coding”). Our contribution focus on the setup and evaluation of a baseline language-independent neural architecture for ICD-10 classification as well as a simple, heuristic multi-language word embedding space. The approach builds on two recurrent neural networks models to extract and classify causes of death from French, Italian and Hungarian death certificates. First, we employ a LSTM-based sequenceto-sequence model to obtain a death cause from each death certificate line. We then utilize a bidirectional LSTM model with attention mechanism to assign the respective ICD-10 codes to the received death cause description. Both models take multi-language word embeddings as inputs. During evaluation our best model achieves an F-score of 0.34 for French, 0.45 for Hungarian and 0.77 for Italian. The results are encouraging for future work as well as the extension and improvement of the proposed baseline system.
Adversarial Domain Adaptation for Variational Neural Language Generation in Dialogue Systems

Domain Adaptation arises when we aim at learning from source domain a model that can perform acceptably well on a different target domain. It is especially crucial for Natural Language Generation (NLG) in Spoken Dialogue Systems when there are sufficient annotated data in the source domain, but there is a limited labeled data in the target domain. How to effectively utilize as much of existing abilities from source domains is a crucial issue in domain adaptation. In this paper, we propose an adversarial training procedure to train a Variational encoder-decoder based language generator via multiple adaptation steps. In this procedure, a model is first trained on a source domain data and then fine-tuned on a small set of target domain utterances under the guidance of two proposed critics. Experimental results show that the proposed method can effectively leverage the existing knowledge in the source domain to adapt to another related domain by using only a small amount of in-domain data.
Overview of the HAHA Task: Humor Analysis Based on Human Annotation at IberEval 2018

This paper presents the HAHA task at IberEval 2018, the first challenge on humor appreciation in the Spanish language. The challenge proposes two tasks related to humor in language: automatic detection and automatic rating of humor in Spanish tweets. In this challenge, we used a corpus of 20,000 annotated tweets in Spanish, where each tweet indicates if it is humorous and the humorous ones contain a funniness score. We summarize the submitted systems and present the general results for both tasks.
Comparative analysis of decidual and peripheral immune cells and immune‐checkpoint molecules during pregnancy in wild‐type and PACAP‐deficient mice

PACAP is a neuropeptide having a major relevance in the nervous system and in several peripheral organs including those of the reproductive system. PACAP‐deficient mice have several morphological, biochemical, behavioral defects, and show reduced fertility. Female reproductive functions such as fertility, mating behavior, maternal behaviors, and implantation alterations have been widely investigated, but no comparative immune analyses are available in pregnant wild‐type (WT) and PACAP knockout (KO) mice.
Relationship between Craving and Early Relapse in Alcohol Dependence: A Short-Term Follow-up Study

Background: The role of craving in alcohol dependence and its relationship with relapse has been studied widely in the past decade. The present study was undertaken to assess the role of craving in short-term relapse of patients seeking treatment for alcohol dependence and changes in craving score at the end of detoxification and at follow-up. Materials and Methods: A total of 34 male individuals with alcohol dependence (excluding comorbid drug dependence, organic or psychiatric disorder), after detoxification and discharge, consented. No anticraving medicine, aversive or psychotherapy, was advised. They were diagnosed on the International Statistical Classification of Diseases-10 using Diagnostic Interview for Genetic Studies. Severity of Alcohol Dependence Questionnaire (SADQ) and Clinical Institute Withdrawal Assessment Scale–Alcohol-Revised (CIWA-AR) were administered at the time of admission. Penn Alcohol Craving Scale (PACS) was applied at the time of discharge and follow-up to measure craving for alcohol. Results: Out of a total of thirty patients analyzed after dropout, 21 relapsed at the end of 1 month. On comparing PACS scores between relapsed and nonrelapsed patients, the difference was significant at both time points, i.e., at discharge and follow-up (t = 4.15, P < 0.0001 and t = 4.01, P < 0.001, respectively). In the total sample, SADQ and CIWA-AR scores were positively correlated (r = 0.47, P = 0.009). PACS at discharge was compared with PACS at follow-up, of which the correlation was high (r = 0.832, P < 0.0001). Conclusion: Craving seems to be a main factor related to relapse. Its measurement with PACS can be a useful tool to predict subsequent drinking and to identify individual risk for relapse during treatment.