Miracle-dz/UniFAR-FTUs huggingface dataset:
Statistical Modeling of Hunting Success Using Hunter Surveys

Different methods are available to estimate the wildlife population development. In this paper a method based on hunter surveys of a Spanish game preserve is proposed. A Poisson model is fitted to estimate the relationship between hunting success and other independent variables. In order to find the most appropriate model, a model selection procedure based on repeated cross validation is used to determine which explanatory variables describe the hunting success better in terms of prediction ability. The estimated model is successful in the case of the red legged partridge (Alectoris rufa). The model can be used for applying different management criteria in a game preserve. Some possibilities are demonstrated for particular scenarios.
AMD3100, a Potent and Specific Antagonist of the Stromal Cell-Derived Factor-1 Chemokine Receptor CXCR4, Inhibits Autoimmune Joint Inflammation in IFN-γ Receptor-Deficient Mice1

Autoimmune collagen-induced arthritis (CIA) in IFN-γR-deficient DBA/1 mice was shown to be reduced in severity by treatment with the bicyclam derivative AMD3100, a specific antagonist of the interaction between the chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4. The beneficial effect of the CXCR4 antagonist was demonstrable when treatment was initiated between the time of immunization and appearance of the first symptoms. Treatment also reduced the delayed-type hypersensitivity response to the autoantigen, collagen type II. These observations are indicative of an action on a late event in the pathogenesis, such as chemokine-mediated attraction of leukocytes toward joint tissues. The notion of SDF-1 involvement was further supported by the observation that exogenous SDF-1 injected in periarthritic tissue elicited an inflammatory response that could be inhibited by AMD3100. The majority of leukocytes harvested from inflamed joints of mice with CIA were found to be Mac-1+ and CXCR4+, and AMD3100 was demonstrated to interfere specifically with chemotaxis and Ca2+ mobilization induced in vitro by SDF-1 on Mac-1+/CXCR4+ splenocytes. We conclude that SDF-1 plays a central role in the pathogenesis of murine CIA, by attracting Mac-1+/CXCR4+ cells to the inflamed joints.
A super-lyophobic PDMS micro-tunnel as a novel microfluidic platform for oxidized Galinstan®

We report a micro pillar array-based super-lyophobic poly(dimethyl siloxane) (PDMS) micro-tunnel as a novel microfluidic platform for oxidized Galinstan<sup>®</sup>. Liquid-metal alloy, Galinstan<sup>®</sup> was expected to be widely utilized in many MEMS applications due to its favorable properties. However, the fact that Galinstan<sub>®</sub> gets easily oxidized and wets on almost nearly any surface is the difficult challenge for utilization of Galinstan<sup>®</sup>. We studied various pitch distance micro pillar arrays and evaluated lyophobicity of Galinstan<sup>®</sup> using static contact angle and sliding angle. A unique approach to fabricate 3-dimensional (3-D) lyophobic micro-tunnel structure was designed using flexible PDMS, which can overcome the limitation of current lithography techniques. It was demonstrated the movement of oxidized Galinstan<sup>®</sup> without wetting.
A Message-Efficient Peer-to-Peer Search Protocol Based on Adaptive Index Dissemination

Resource search is a fundamental problem in large-scale and highly dynamic Peer-to-Peer (P2P) systems. Unstructured search approaches are widely used because of their flexibility and robustness. However, such approaches incur high communication cost. The index-dissemination-based search is a kind of efficient unstructured search approach. We investigate such approaches with respect to minimize the system communication cost. Based on a dynamic system model that peers continuously leave and join, we solve two problems. One problem is how to efficiently disseminate and maintain a given number of indices. Another is to determine the optimal number of indices for each resource object of a given popularity. Finally, we propose an optimized index dissemination scheme which is fully decentralized and self-adaptive. A remarkable advantage is that the scheme yields no additional communication cost to achieve the self-adaptive feature.
[Aetiologies of lithium overdose: 10-year experience of Marseille poison centre].

OBJECTIVE Lithium is used for control of bipolar disorders. In order to precise the different circumstances at the origin of poisonings, the authors present the cases of lithium intoxication observed in the Marseille poison centre between January 1991 and December 2000. STUDY DESIGN Retrospective study. METHODS Three hundred and four cases were observed during the studied period (1 patient a case), concerning 6 different circumstances. For 3 of them, the symptoms were mild: accidental ingestion with children (13 cases); mistakes on the quantities of ingested tablets (43 cases); elevation of lithium blood level due to diuretic therapy (8 cases). For 2 other circumstances, the clinical signs were more severe: treated patients who developed renal failure (15 cases, 6 patients managed in intensive care unit [ICU], 1 death) or dehydration (35 cases, 8 patients treated in ICU and 1 death). Finally, the most severe cases were collected with suicide attempts. Fifty-six percent of the patients were managed in ICU, 5% needed haemodialysis, 10% had cardiac (repolarization disturbances) or neurological (seizures) complications, 2% died. CONCLUSION The severity of lithium poisonings depends of the circumstances. Ingestion of high quantities of sustained released tablets is the most dangerous situation. Accidental ingestion, even with children, must be considered as less severe situations.
The SoC design of a versatile biomedical signal processor for potentiostat

This paper presents a versatile and portable System on a Chip (SoC) biomedical signal processor which collects and analyzes biomedical signals in real-time. Measurements of the melatonin-mixed potassium ferrocyanide solution and patient specimen experiment are presented for verification. The measurement results show that this proof-of-concept prototype functions as a traditional potentiostat with high precision discrete components.
Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women.

BACKGROUND Exposure to environmental tobacco smoke (ETS) is considered to be a major lung cancer risk factor for never smokers. We investigated the hypothesis that never-smoking women who are exposed to ETS and develop lung cancer are a genetically susceptible population. METHODS Archival tumor tissues were analyzed from 106 never-smoking women enrolled in a case-control study of ETS (and other personal and environmental factors) and lung cancer risk. We analyzed germline polymorphisms in genes that have been associated with cancer susceptibility and whose products activate (cytochrome P450 1A1 [CYP1A1]) and detoxify (glutathione S-transferases M1 [GSTM1] and T1 [GSTT1]) chemical carcinogens found in tobacco smoke. RESULTS When compared with never smokers who had no ETS exposure and developed lung cancer (n = 55), never smokers with exposure to ETS who developed lung cancer (n = 51) were more likely to be deficient in GSTM1 activity (i.e., were GSTM1 null) because of a genetic polymorphism in the GSTM1 gene (odds ratio = 2.6; 95% confidence interval = 1.1-6.1). A statistically significant rising trend in risk occurred with increasing ETS exposure (two-sided P =. 02), reaching a more than sixfold excess risk in those exposed to 55 pack-years of ETS (ETS pack-year = ETS produced by an active smoker, within a confined space such as a room, who smokes one pack of cigarettes a day for a year). No evidence was found of associations between GSTT1 deficiency or the CYP1A1 valine variant and lung cancer risk due to ETS exposure. CONCLUSIONS A common genetic polymorphism divides the population of never smokers into two groups of approximately equal size, one (homozygous carriers of the GSTM1 null allele) that has a statistically significant greater risk of lung cancer from ETS than the other (heterozygous or homozygous carriers of the wild-type GSTM1 allele).
UBC9 Autosumoylation Negatively Regulates Sumoylation of Septins in Saccharomyces cerevisiae*

Sumoylation regulates a wide range of cellular processes. However, little is known about the regulation of the SUMO machinery. In this study, we demonstrate that two lysine residues (Lys-153 and Lys-157) in the C-terminal region of the yeast E2-conjugating enzyme Ubc9 are the major and minor autosumoylation sites, respectively. Surprisingly, mutation of Lys-157 (ubc9K157R) significantly stimulates the level of Ubc9 autosumoylation at Lys-153. The functional role of Ubc9 autosumoylation is exemplified in our findings that cell cycle-dependent sumoylation of cytoskeletal septin proteins is inversely correlated with the Ubc9 autosumoylation level and that mutation of the Ubc9 autosumoylation sites results in aberrant cell morphology. Our study elucidates a regulatory mechanism that utilizes automodification of the E2 enzyme of the sumoylation machinery to control substrate sumoylation.
Experimental strategies for identification of cis-regulatory elements

Gene expression is regulated by multi-protein complexes binding to short non-coding regions of genomic DNA, called cisregulatory elements. A long-term goal of genomics is to identify and annotate all essential elements of the genome. Most coding elements of the genome have been identified and annotated; however, most regulatory elements have not. This chapter describes a method for the high throughput identification of DNA-protein interactions to identify cisregulatory elements. Introduction DNA protein interactions control gene expression An important aspect of the analysis of genomic DNA is not only identifying its structure or sequence, but also its function. If its function is to encode sequences of amino acids, decoding it is trivial. The human genome encodes at least two important functions. The first, DNA sequence that encodes protein sequence, has now been almost completely identified. The second, DNA sequence that binds specific proteins, is almost completely unknown. In eukaryotes, the DNA sequence that binds specific proteins is known as cisregulatory elements. Multi-protein complexes bind to these short, specific DNA sequences regulating the transcription process. The human genome contains vast amounts of cis-regulatory elements, most of which have not yet been identified. These regulatory sequences are responsible for directing spatial and temporal patterns of gene expression, which affect metabolic requirements and developmental programs. Cis-regulatory elements are generally less than 20 base pairs and usually located in the promoter region of the regulated gene. The regulatory elements can be located upstream or downstream from the transcription start site. The simplest binding model involves a molecule (a particular region in a single protein tertiary structure, P) that can bind to a specific binding site (a specific sequence of DNA, D) and form a resulting complex, C, which can enhance or repress expression.
CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo

Chromosomal translocations that generate oncogenic fusion proteins are causative for most pediatric leukemias and frequently affect the MLL/KMT2A gene. In vivo modeling of bona fide chromosomal translocations in human hematopoietic stem and progenitor cells is challenging but essential to determine their actual leukemogenic potential. We therefore developed an advanced lentiviral CRISPR-Cas9 vector that efficiently transduced human CD34+ hematopoietic stem and progenitor cells and induced the t(11;19)/MLL-ENL translocation. Leveraging this system, we could demonstrate that hematopoietic stem and progenitor cells harboring the translocation showed only a transient clonal growth advantage in vitro. In contrast, t(11;19)/MLL-ENL-harboring CD34+ hematopoietic stem and progenitor cells not only showed long-term engraftment in primary immunodeficient recipients, but t(11;19)/MLL-ENL also served as a first hit to initiate a monocytic leukemia-like disease. Interestingly, secondary recipients developed acute lymphoblastic leukemia with incomplete penetrance. These findings indicate that environmental cues not only contribute to the disease phenotype, but also to t(11;19)/MLL-ENL-mediated oncogenic transformation itself. Thus, by investigating the true chromosomal t(11;19) rearrangement in its natural genomic context, our study emphasizes the importance of environmental cues for the pathogenesis of pediatric leukemias, opening an avenue for novel treatment options.
Bacteria Induced Morphologic Changes.∗

Summary Inoculation of Streptococcus sp. into germfree rats resulted in dramatic cecal changes within 24 hours. The weight of the cecum and its contents were reduced almost 50% and an apical aggregate of lymphatic tissue appears as a grossly visible entity, lacking only the more densely clumped nature of that found in classic rats. Exploratory work with mice confirmed this observation. Although the size (weight or surface area) of the cecal wall of the germfree rats is twice the size of that in classic rats, no change was noted when germfree rats were monoinoculated with Streptococcus sp. The cervical lymph nodes increased 3-fold following inoculation of germfree mice. This exploratory work illustrates the potential of gnotophoric animals in the study of defense mechanisms. The authors acknowledge the assistance of G. G. Caldwell in the bacteriological work.
A 40-Gb/s transmitter with 4∶1 MUX and subharmonically injection-locked CMU in 90-nm CMOS technology

A low-power low-jitter 40-Gb/s transmitter incorporating triple-resonance technique and subharmonically injection-locked CMU is presented. Designed and fabricated in 90-nm CMOS technology, this chip provides 4∶1 multiplexing and achieves 454 fs,rms output data jitter while consuming only 325 mW from a 1.5-V supply.
[Exploration of Renal Microcirculation Perfusion During Cardiopulmonary Bypass with Contrast-enhanced Ultrasound].

OBJECTIVE To investigate the alteration of renal microcirculation perfusion during cardiopulmonary bypass (CPB) in adult patients with contrast-enhanced ultrasound (CEU). METHODS Six patients undergoing cardiac surgery with CPB and twelve patients undergoing non-cardiac surgery were enrolled and classified into CPB group and control group. CEU images of kidney were collected at the point of 30 min after CPB or 5 min after anesthesia induction respectively. Time intensity curve (TIC) was derived from three regions of interest (ROD. superficial cortex, deep cortex and medulla. Parameters including wash in slope (a), area under curve (AUC), peak intensity (PI) and time to peak (TTP) were calculated based on gamma-variant function. RESULTS CEU showed a significant reduction of AUC in all three regions (superficial cortex, deep cortex and medulla) during CPB, compared with anesthetic condition. Ultrasound contrast agent-related adverse reactions were not occurred in all enrolled patients. CONCLUSION Renal microcirculation perfusion was dramatically reduced during CPB, especially in the medulla. CEU could be detected the renal microcirculation perfusion in the perioperative period of cardiac surgery.
Copy Move Image Forgery Detection using Wavelet transform

Image manipulation is not a new trend and it exists from the time when photography was innovated. In the recent years, many forgery detection methods and techniques are proposed. Photo image forgery may include Copy-Move Forgery or Cloning and Copy-Create Image Forgery. There are few methods for forgery detection. Though many image forgery detections previously exist, with the change in algorithms the efficiency in the outputs will also be varied. The algorithm that implemented, identifies the forged part in the copy move forged input image. The algorithm is implemented using wavelet transform. For feature extraction, average information, that is, entropy of blocks of the image is calculated. The algorithm could able to identify the forged part in image which was copied and moved or copied, moved and scaled. Due to result efficiency we can use it in identifying forged images in civil, military and in other security essential services.
Detecting volatile organic compounds using a resonant microcantilever-based system

This paper presents a system based on an array of eight micro-cantilevers for volatile organic compounds (VOC) detection. Sensors based on a micromechanical array of silicon and diamond cantilevers are sensitized for the detection of analytes using polymer coatings. Connections to the sensors are not permanent and they can be easily changed for another application or for maintenance. Detections of VOCs are demonstrated.
On isometry groups and maximal symmetry

We study problems of maximal symmetry in Banach spaces. This is done by providing an analysis of the structure of small subgroups of the general linear group GL(X ), where X is a separable reflexive Banach space. In particular, we provide the first known example of a Banach space X without any equivalent maximal norm, or equivalently such that GL(X ) contains no maximal bounded subgroup. Moreover, this space X may be chosen to be super-reflexive. In memory of Greg Hjorth (1963–2011) and Nigel Kalton (1946–2010).
Kinectics studies of adsorption of RR-120 dye using spirulina platensis microalgae and commercial activated carbon as adsorbents from aqueous effluents

Comparative study of the removal of the dye Reactive Red 120 (RR-120) from aqueous effluents from textile industry using microalgae Spirulina platensis (SP) and commercial active carbon (AC) were carried out. The batch adsorption systems were evaluated with respect to pH, agitation time, temperature and initial concentration of the dye. The maximum adsorption capacity for dye RR-120 were found at pH 2 and 298K. The general kinetic model was the most appropriate to explain the adsorption of RR-120 using SP and CA. The SP and AC adsorbents showed good performance for treatment of simulated textile industrial effluents by removing from 94.4 to 99.0% and from 93.6 to 97.7%, respectively, of dye mixtures in high saline concentrations.
Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree

To investigate the expressions of 15‐lipoxygenase (15‐LO) and 5‐lipoxygenase (5‐LO) in leukocytes and the changes of blood lipoxin A4(LXA4), leukotriene (LT)B4 and LTC4 in children with asthma, and to explore the relationship between the blood eicosanoids and one of serum high‐sensitivity C‐reactive protein (hsCRP), interleukin (IL)‐5, IL‐8 and IL‐13 and IgE in children with asthma.
High‐resolution 3D radial bSSFP with IDEAL

Radial trajectories facilitate high‐resolution balanced steady state free precession (bSSFP) because the efficient gradients provide more time to extend the trajectory in k‐space. A number of radial bSSFP methods that support fat–water separation have been developed; however, most of these methods require an environment with limited B0 inhomogeneity. In this work, high‐resolution bSSFP with fat–water separation is achieved in more challenging B0 environments by combining a 3D radial trajectory with the IDEAL chemical species separation method. A method to maintain very high resolution within the timing constraints of bSSFP and IDEAL is described using a dual‐pass pulse sequence. The sampling of a unique set of radial lines at each echo time is investigated as a means to circumvent the longer scan time that IDEAL incurs as a multiecho acquisition. The manifestation of undersampling artifacts in this trajectory and their effect on chemical species separation are investigated in comparison to the case in which each echo samples the same set of radial lines. This new bSSFP method achieves 0.63 mm isotropic resolution in a 5‐min scan and is demonstrated in difficult in vivo imaging environments, including the breast and a knee with ACL reconstruction hardware at 1.5 T. Magn Reson Med 71:95–104, 2014. © 2013 Wiley Periodicals, Inc.
EM-driven compact cell topology selection for explicit size reduction of hybrid rat-race couplers

An optimization-based approach to size reduction of hybrid microwave couplers is proposed. Our technique allows for selection of the most appropriate compact cell (as an elementary building block of a miniaturized coupler) that ensures minimum footprint area of the entire circuit. The selection process is coupled with an explicit coupler size reduction realized by direct gradient-based optimization of the cell dimensions. Satisfaction of electrical performance parameters is ensured by means of a penalty function approach. The presented methodology is explained and demonstrated using a hybrid rat-race coupler of a rectangular type, implemented in microstrip technology and operating at 1 GHz. For circuit size reduction, a pool of four compact cells of various topologies is considered.
Altered Expression of Angiopoietins During Blood-Brain Barrier Breakdown and Angiogenesis

Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) belong to a novel family of endothelial growth factors that function as ligands for the endothelial-specific receptor tyrosine kinase, Tie-2. Ang-1 reduces endothelial permeability of noncerebral vessels and has a major role in vascular stabilization and maturation, whereas Ang-2 is thought to be an endogenous antagonist of the action of Ang-1 at Tie-2. Expression of these ligands at the mRNA and protein level were studied during both blood-brain barrier (BBB) breakdown and cerebral angiogenesis occurring in the rat cortical cold-injury model by RT-PCR analysis and immunohistochemistry respectively, during a time course of 6 hours to 6 days. In addition, immunohistochemical detection of fibronectin was used to detect BBB breakdown at the lesion site and dual labeling was used to determine whether the vessels demonstrating BBB breakdown expressed endothelial Ang-1 or Ang-2. Endothelial Ang-1 and Tie-2 proteins were present in all cerebral vessels of normal brain including those of the choroid plexuses, whereas both these proteins as well as Ang-2 were present in choroid plexus epithelium and in ependymal cells, suggesting that angiopoietins have an autocrine effect on these cell types as well. In contrast, in the early phase after injury during the known period of BBB breakdown, increased Ang-2 mRNA and protein and decreased endothelial Ang-1 and Tie-2 proteins were observed. Two to 6 days after injury, the progressive increase in Ang-1 mRNA and protein and the decrease in Ang-2 coincided with cerebrovascular angiogenesis. Confocal microscopy showed colocalization of both Ang-1 and Ang-2 in endothelium of lesion vessels, and our observation of colocalization of Ang-1 and Ang-2 in polymorphonuclear leukocytes and macrophages has not been reported previously. This study demonstrates that Ang-1 is an important factor in maintaining normal homeostasis in the brain. Thus Ang-1 therapy may have therapeutic potential in reducing BBB breakdown and the ensuing edema after massive brain injury.
Diagnosis of Intermittent Faults with Conditional Preferences

Diagnosis of intermittent faults is significantly different from diagnosis of permanent faults, especially when selecting one or several preferred diagnoses. In this paper, we describe a new modeling approach for intermittent faults based on Past Time Linear Temporal Logic (PTLTL), and we suggest a conditional diagnosis selection approach based on Conditional Preference theories. We describe how intermittent faults can create diagnosis instability and show how our approach can be used to mitigate it. We then describe an incremental way to compute diagnoses at each time step, and a reduction of the incremental diagnosis computation to a MaxSAT query. Finally we discuss some limitations of our diagnoser and how they can be overcome.