Miracle-dz/UniFAR-FTUs huggingface dataset:
Assembly and cell surface presentation of NMDA receptors

NMDA receptors composed of GluN1 (GRIN1) and various combinations of GluN2 (GRIN2) subunits (GluN2A, GluN2B, GluN2C and GluN2D) are all delivered to the plasma membrane where they are anchored to postsynaptic density regions via the interaction with the PSD-95 family of proteins (DLG1, DLG2, DLG3 and DLG3) (Cui et al. 2007). Details of trafficking from the endoplasmic reticulum to the plasma membrane for the majority of GluN1:GluN2 di-heteromers and tri-heteromers, except for GluN1:GluN2B NMDA receptors, are not known. calmodulin-dependent kinase, CaMKII, is enriched in postsynaptic density (PSD) and co-localizes with NMDA receptors. CaMKII can independently bind to alpha-actinin-2 (ACTN2), densin-180 (LRRC7) and the NMDA receptor subunit GluN2B (GRIN2B). Any of the four CAMK2 isoforms, CAMK2A, CAMK2B, CAMK2D or CAMK2G, which associate to form homomeric or heteromeric CaMKII dodecamers, can bind to ACTN2 and GluN2B, while LRRC7 shows the highest affinity for CAMK2A. Binding of CaMKII to the NMDA receptor-associated proteins is independent of CaMKII phosphorylation
The continuing struggle to clean London's air (加藤秀雄教授・外岡豊教授・山下勇一教授退職記念号)

Pollution from smoke has been a problem ever since people first started to make fires in order to cook food, to keep warm, and to work metals. The problem became far worse in London with its rapid growth and industrialisation during the nineteenth century, but little effective action was taken until the London fog of 5 to 8 December 1952 that resulted in the premature death of between 3,500 and 4,000 people. The Clean Air Act then led to a steady reduction in smoke and sulphur dioxide concentrations, aided by the replacement of coal by oil and then of oil by gas from the North Sea. The early regulations limiting air pollutant emissions from vehicles were effective, and were progressively strengthened. However, over the last decade it has become increasingly evident that many vehicles that meet the requirements of the regulations under test conditions, fail to do so on the road. Nitrogen dioxide (NO 2) emissions from diese engined passenger cars and light trucks are a particular problem, with little prospect of London meeting the NO 2 requirements of the European Union Ambient Air Quality Directive for some years. The Mayor of London introduced a Low Emission Zone in 2008 and is now proposing to supplement this with an Ultra-Low Emission Zone from 2020 in the hope of achieving compliance with the Directive. Introduction Pollution from smoke has been a problem ever since people first started to make fires in order to cook food, to keep warm, and to work metals. London in particular had long been recognised as having an air pollution problem resulting from the burning of coal in particular, with a Royal Proclamation prohibiting the burning of sea coal (1) as early as the fourteenth century. At this time coal was mainly used in industrial processes such as the production of lime for use in building construction (Brimblecombe 1987). It was not until the seventeenth century that coal began to be used to a significant extent to heat people ’ s homes but many founds its sulphurous fumes objectionable. John Evelyn (1661) presented King Charles II with a treatise entitled Fumifugium: or the Inconveniencie of the Aer and Smoak of London Dissipated on the problem of smoke, suggesting that smoke pollution would shorten the lives of people living in London. There is plenty of evidence of interest in the causes and effects of air pollution in the eighteenth century, but it was hardly an age of environmental activism. Physicians advised their asthmatic and consumptive patients to move to the country where they could avoid the harmful effects of city air (Brimblecombe 1987). But even the country was not immune from the effects of London smoke. Gilbert White (1789), the vicar The continuing struggle to clean London ’ s air 199 社会科学論集 第148号 2016.8 The continuing struggle to clean London ’ s air
Physiotherapeutic approach on the late phase of chikungunya: a case report

Introducao: o boletim epidemiologico de abril de 2016 informou 39.017 casos provaveis de febre de chikungunya no pais. Na fase aguda da doenca os principais sintomas sao: febre alta, poliartralgia, dores nas costas, dor de cabeca e fadiga; enquanto que na fase tardia estao presentes a poliartralgia ou dores musculo-esqueleticas, que frequentemente apresentam-se com duracao prolongada. Descricao: o paciente apresentava na fase tardia como principais queixas: dores severas nas articulacoes dos tornozelos, punhos, cotovelos e ombros. O manejo clinico foi constituido de sessoes com ultrassom continuo com frequencia de 1 MHz, Laser infravermelho com dosagem de 4J e 3s por ponto; TENS-burst com largura de pulso de 250 us e Frequencia de 2Hz, realizado por 10 dias. O tratamento fisioterapeutico proposto foi inovador, pois nao ha na literatura tratamentos complementares que possam diminuir o uso de analgesicos e causar conforto prolongado ao paciente ratificado pelo EVA e o SF-36. Discussao: o uso do ultrassom e do laser de baixa intensidade sao utilizados no tratamento de manifestacoes reumaticas cronicas com o objetivo de reduzir a inflamacao, dor e rigidez articular. Por conseguinte, foi notavel a reducao do quadro algico e melhora da qualidade de vida da paciente ao longo de dez sessoes consecutivas com o protocolo proposto no presente estudo, sendo assim surge a necessidade de novas pesquisas acerca do assunto para que seja possivel fazer um manejo clinico baseado em evidencias sobre o tema.
Up-Regulation of Insulin/Insulin-Like Growth Factor-I Hybrid Receptors during Differentiation of HT29-D4 Human Colonic Carcinoma Cells.

To assess the autocrine function of insulin-like growth factor II (IGF-II) in the balance of proliferation and differentiation in HT29-D4 human colonic cancer cells, we studied the expression of IGF-I receptors (IGF-IR) and insulin receptors (IR) in relation to the state of cell differentiation. IGF-IR and IR were expressed in both undifferentiated and enterocyte-like differentiated HT29-D4 cells. IGF-IR had two isoforms with a 97-kDa and a 102-kDa β-subunit. In addition, HT29-D4 cells expressed hybrid receptors (HR) formed by the association of two αβ heterodimers from both IR and IGF-IR. HR were evidenced through 1) inhibition of IGF-I binding by the B6 anti-IR antibody and 2) immunoprecipitation with the α-IR3 anti-IGF-IR antibody, which revealed an additional 95-kDa IR β-subunit that disappeared when the heterotetrameric receptor was dissociated by disulfide reduction into αβ heterodimers before immunoprecipitation. Like IGF-IR, HR had a high affinity for IGF-I (Kd, ∼1.5 nm), but did not bind insulin .
Forecasting of Particleboard Consumption in Iran Using Univariate Time Series Models

The performance of the Autoregressive Integrated Moving Average )ARIMA) model and Double and Holt-winters exponential smoothing techniques for forecasting the consumption of particleboard in Iran are compared. Annual time series data from 1978 to 2009 in the modeling process, and observations from 2010 to 2012 were used to check the accuracy of the models’ forecasting performance. Also, the models’ performances were calculated in terms of RMSE criterion, and the consumption of particleboard in Iran was forecasted up to the year 2017 using the most appropriate model. The results of comparing different forecast models showed that the ARMA (2,1) model yielded the lowest RMSE value compared to the other two models, which makes it more appropriate for the prediction of consumption of particleboard in Iran. Results also revealed that there might be an increasing trend in the consumption of particleboard, i.e., an average annual increasing rate calculated as 5% for particleboard. Thus, it was predicted that the consumption of particleboard would increase from 901,652 m3 in 2012 to 1,178,320 m3 in 2017.
Zur Ideengeschichte von Buchführung, Kostenrechung und Controlling vor dem Hintergrund ihres historischen Kontexts

This essay provides a survey of the evolution and the developments of bookkeeping, internal cost accounting and management control and Covers a time-period of over 5.500 years. It starts with the first written texts of man-kind, economic writings from ancient Mesopotamia, and in the following discusses ages such as the ancient world of Greeks and Romans, the medieval times and feudalism, absolutism and mercantilism, the Industrial Revolution and finally the 20th century including the present times. It is shown that the developments in bookkeeping and cost accounting have regularly been a reaction to contemporary problems and influenced by the Zeitgeist. Other than in hitherto existing summaries on the history of bookkeeping and accounting, which chronologically enumerate different techniques and practices, this text additionally delivers an outline of each particular era and its characteristics of economy, society and organisational structures. Therefore this paper -which addresses students of economics and business administration, practitioners, researchers from different fields as well as people generally interested in the economy - sensitises to the complex and interdisciplinary coherences of "the economy" necessary for an understanding of this subject.
Anaphylactic or anaphylactoid reactions in patients undergoing cardiac surgery.

OBJECTIVE To examine the clinical features, treatment, and outcome of anaphylactic and anaphylactoid reactions during cardiac surgery. DESIGN Retrospective descriptive study. SETTING A specialized referral anesthetic allergy clinic at a university teaching hospital. PARTICIPANTS Twenty-three cardiac surgical patients referred after reactions resembling anaphylaxis. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS The database of the anesthetic allergy clinic was examined, and the data for patients who developed anaphylactic or anaphylactoid reactions were collated and summarized. Twenty-three cardiac surgical patients who experienced signs of anaphylactic or anaphylactoid reactions during anesthesia and surgery from 8 cardiac surgical centers in a major city were referred to the clinic. Cephalosporin antibiotics (30%) and gelatin solutions (Hemaccel) (26%) were the most common (56%) causes of the reactions. Most reactions occurred before the start of cardiopulmonary bypass. Although metaraminol was the first vasopressor used in 18 of 23 patients, it was not effective in 14 patients. Response to epinephrine was immediate and effective in 88% of cases. Rapid placement onto cardiopulmonary bypass facilitated a good outcome and permitted all but one operation to proceed as planned. No intraoperative or postoperative deaths were recorded. CONCLUSION Of the anaphylactic and anaphylactoid reactions, 60% occurred before cardiopulmonary bypass, and these were caused by antibiotics and gelatin solution. The results from this limited database showed that cardiac surgery proceeded without complications after cardiovascular collapse caused by anaphylactic or anaphylactoid reactions. Rapid institution of cardiopulmonary bypass may be life-saving and should be considered.
Visualizing Oceans of Data: Educational interface design

The Oceans of Data project is an NSF-funded, 2-year interdisciplinary review of literature and expert opinion pertinent to making interfaces to large scientific databases accessible to and usable by novice learners and their instructors. The Visualizing Oceans of Data Knowledge Status Report (KSR) presents cross-cutting and visualization-specific guidelines that highlight how interface design features can address and ameliorate challenges novice users face as they navigate complex databases to find data, and construct and look for patterns in maps, graphs, animations and other data visualizations. Integrating information from hundreds of diverse sources, the resulting report is a set of over seventy guidelines that represents a synthesis of knowledge derived from key bodies of literature in the cognitive sciences, neurosciences, learning sciences, computer sciences, and many other disciplines. This paper presents the results of this work in the form of a small sampling of example guidelines from the full Visualizing Oceans of Data report.
Association of Genetic Variation in Il28B with Hepatitis C Treatment-Induced Viral Clearance in the Chinese Han Population

Background Genome-wide association studies have recently shown that the rs12979860 polymorphism in IL28B is associated with the response to chronic hepatitis C treatment. The aim of this study was to investigate whether rs12979860 could be used as a predictive marker for end-of-treatment response (ETR) or sustained virological response (SVR) in the Chinese Han population. Methods The rs12979860 genotype was detected in 259 individuals infected with HCV by DNA sequencing. Among them, 120 patients were administered complete pegylated interferon-α and ribavirin combination therapy and 92 patients were followed for 24 weeks after the cessation of treatment and were divided into different groups according to outcomes of treatment. Results The rs12979860 genotype CC was the primary genotype (87.64%, 227/259) and genotype TT was found in only one individual within this cohort. The patients with the rs12979860 genotype CC had higher rates of ETR (P=0.0044) and SVR (P=0.0046) than the patients with N-CC (CT or TT). In multivariate analyses, the rs12979860 genotype CC was associated with a substantial difference in rates of achieving ETR (odds ratio [OR] 8.983, 95% confidence interval [CI] 2.173–37.145; P=0.0024) and SVR (OR 24.298, 95% CI 2.27–259.90; P=0.0083). Conclusions This study demonstrated for the first time that the rs12979860 variation in IL28B could be a predictor of ETR and SVR in Chinese Han patients infected with HCV. The high frequency of the rs12979860 genotype CC might explain why the SVR rate is higher than that of the average global population.
Negative Symptoms, Trauma, and Autobiographical Memory: An Investigation of Individuals Recovering From Psychosis

Psychological research on negative symptoms in schizophrenia is scarce. The aim of this study was to explore the relationship between negative symptoms and trauma in individuals recovering from a psychotic illness. Specifically, the aim was to examine the association between negative symptoms and traumatic reactions to psychosis and to hospitalization. We were also interested in the association between traumatic reactions and autobiographical memory. The design was a cross-sectional investigation of 38 people recovering from functional psychotic illness. Hypotheses were examined using correlations between measures of negative symptoms, posttraumatic avoidance, and specificity of autobiographical retrieval. Negative symptoms were found to be significantly associated with avoidance of traumatic memories related to psychosis and hospitalization and with a lack of specificity in autobiographical recall. Further analysis showed that avoidance related to psychosis and low specificity in recall were significant predictors of negative symptoms. These data suggest that people who avoid traumatic memories of psychosis and hospitalization have more negative symptoms and retrieve fewer specific autobiographical memories. The possibility that negative symptoms may be reactive is explored, along with the implications for our theoretical and clinical understanding. The methodological limitations of the study and ideas for future research are discussed.
Processus inter et intra dans l'acquisition et le fonctionnement du langage

L'etude des processus d'acquisition et du fonctionnement du langage est un domaine de choix pour cerner les contributions de l'inter et de l'intrasubjectif ainsi que la complexite et la fecondite de leurs interrelations. D'une part, le langage, etant un objet de connaissance social par nature, arbitraire et conventionnel, ne peut s'acquerir qu'a travers l'intersubjectivite : c'est a travers le langage d'autrui, a travers les echanges qui se deroulent dans l'interaction avec autrui, que l'enfant est confronte aux proprietes de l'objet langagier aussi bien dans sa structure (signification, lexique et grammaire), que dans ses fonctions communicatives (la pragmatique). De ce point de vue, on peut supposer que differentes strategies employees par l'adulte dans son interaction avec l'enfant sont susceptibles de susciter du progres. D'autre part, s'agissant de l'acquisition stable et autonome de connaissances nouvelles, a chaque moment, l'influence des experiences intersubectives ne peut se comprendre qu'en relation avec l'intrasubjectif, c'est a dire, en rapport avec la maniere qu'a l'enfant d'agir en retour, du type de traitement que l'enfant peut faire de ses experiences intersubjectives, ainsi qu'avec l'etat de connaissance que l'enfant a d'autres aspects du langage et de son niveau de developpement plus general.
Homological algebra of knots and BPS states

It is known that knot homologies admit a physical description as spaces of open BPS states. We study operators and algebras acting on these spaces. This leads to a very rich story, which involves wall crossing phenomena, algebras of closed BPS states acting on spaces of open BPS states, and deformations of Landau-Ginzburg models. One important application to knot homologies is the existence of "colored differentials" that relate homological invariants of knots colored by different representations. Based on this structure, we formulate a list of properties of the colored HOMFLY homology that categorifies the colored HOMFLY polynomial. By calculating the colored HOMFLY homology for symmetric and anti-symmetric representations, we find a remarkable "mirror symmetry" between these triply-graded theories.
A Series Resonant Energy Storage Cell Voltage Balancing Circuit

A novel cell voltage equalizer using a series <inline-formula> <tex-math notation="LaTeX">$LC$ </tex-math></inline-formula> resonant converter is proposed for series-connected energy storage devices, namely, battery or super (or ultra)-capacitor cells. The proposed circuit is an active voltage equalization circuit for energy storage devices that is low cost, small in size, and equalizes the voltages quickly. Compared to the state-of-the-art solutions, the proposed series <inline-formula> <tex-math notation="LaTeX">$LC$ </tex-math></inline-formula> resonant circuit eliminates the complexity of multiwinding transformers, and it can balance series-connected energy storage devices in a short time by transporting energy successively between the cells having highest voltage difference. The detailed circuit operation and theoretical analysis are provided. Simulation and experimental results are presented to demonstrate the voltage equalization process from an initial voltage difference of 527 mV to a final difference of 10 mV in 900 s for three series-connected supercapacitor cells.
Optimal Value of Series Capacitors for Uniform Field Distribution in Transmission Line MRI Coils

Transmission lines are often used as coils in high field magnetic resonance imaging (MRI). Due to the distributed nature of transmission lines, coils based on them produce inhomogeneous field. This work investigates application of series capacitors to improve field homogeneity along the coil. The equations for optimal values of evenly distributed capacitors are derived and expressed in terms of the implemented transmission line parameters. The achieved magnetic field homogeneity is estimated under quasistatic approximation and compared to the regular transmission line resonator. Finally, a more practical case of a microstrip line coil with two series capacitors is considered.
Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells

ABSTRACT It has been shown previously that some immortalized human cells maintain their telomeres in the absence of significant levels of telomerase activity by a mechanism referred to as alternative lengthening of telomeres (ALT). Cells utilizing ALT have telomeres of very heterogeneous length, ranging from very short to very long. Here we report the effect of telomerase expression in the ALT cell line GM847. Expression of exogenous hTERT in GM847 (GM847/hTERT) cells resulted in lengthening of the shortest telomeres; this is the first evidence that expression of hTERT in ALT cells can induce telomerase that is active at the telomere. However, rapid fluctuation in telomere length still occurred in the GM847/hTERT cells after more than 100 population doublings. Very long telomeres and ALT-associated promyelocytic leukemia (PML) bodies continued to be generated, indicating that telomerase activity induced by exogenous hTERT did not abolish the ALT mechanism. In contrast, when the GM847 cell line was fused with two different telomerase-positive tumor cell lines, the ALT phenotype was repressed in each case. These hybrid cells were telomerase positive, and the telomeres decreased in length, very rapidly at first and then at the rate seen in telomerase-negative normal cells. Additionally, ALT-associated PML bodies disappeared. After the telomeres had shortened sufficiently, they were maintained at a stable length by telomerase. Together these data indicate that the telomerase-positive cells contain a factor that represses the ALT mechanism but that this factor is unlikely to be telomerase. Further, the transfection data indicate that ALT and telomerase can coexist in the same cells.
Automatic failure analysis system for high density DRAM

In this paper, the automatic failure analysis method based on the random bit failure causing the major yield drop in DRAM and the analysis system named "SEC FAILURE ANALYSIS SYSTEM" are discussed. This system is developed for the accurate and rapid electrical analysis of the failure in a statistical manner in order to make a quick feedback to the manufacturing process.
Interactive Tooth Segmentation of Dental Models

The accurate segmentation of the teeth from the triangle mesh is an important step in computer-aided orthodontic. Because teeth come in different shapes and their arrangements vary substantially from one individual to another, tooth segmentation is difficult. This paper proposes a new method to accurately segment the teeth interactively. Based on curvature values of the triangle mesh, feature points are connected to feature regions. After feature lines are extracted from regions, feature contour can be obtained with the help of user supplied information. Using feature contour, the tooth are segmented accurately and individually
A Context-Aware based Authorization System for Pervasive Grid Computing

— This paper describes the authorization system architecture for Pervasive Grid environment. It discusses the characteristics of classical authorization system and requirements of the authorization system in pervasive grid environment as well. Based on our analysis of current systems and taking into account the main requirements of such pervasive environment, we propose new authorization system architecture as an extension of the existing grid authorization mechanisms. This architecture not only supports user attributes but also context attributes which act as a key concept for context-awareness thought. The architecture allows authorization of users dynamically when there are changes in the pervasive grid environment. For this, we opt for hybrid authorization method that integrates push and pull mechanisms to combine the existing grid authorization attributes with dynamic context assertions. We will investigate the proposed architecture using a real testing environment that includes heterogeneous pervasive grid infrastructures mapped over multiple virtual organizations. Various scenarios are described in the last section of the article to strengthen the proposed mechanism with different facilities for the authorization procedure.