Miracle-dz/UniFAR-FTUs huggingface dataset:
MTI-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression

Membrane type 1 metalloprotease (MT1-MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly by activating pro-MMP2. We investigated the effects of MT1-MMP overexpression on in vitro and in vivo properties of human breast adenocarcinoma MCF7 cells, which do not express MT1-MMP or MMP-2. MT1-MMP and MMP-2 cDNAs were either transfected alone or cotransfected. All clones overexpressing MT1-MMP 1) were able to activate endogenous or exogenous pro-MMP-2, 2) displayed an enhanced in vitro invasiveness through matrigel-coated filters independent of MMP-2 transfection, 3) induced the rapid development of highly vascularized tumors when injected subcutanously in nude mice, and 4) promoted blood vessels sprouting in the rat aortic ring assay. These effects were observed in all clones overexpressing MT1-MMP regardless of MMP-2 expression levels, suggesting that the production of MMP-2 by tumor cells themselves does not play a critical role in these events. The angiogenic phenotype of MT1-MMP-producing cells was associated with an up-regulation of VEGF expression. These results emphasize the importance of MT1-MMP during tumor angiogenesis and open new opportunities for the development of antiangiogenic strategies combining inhibitors of MT1-MMP and VEGF antagonists. - Sounni, N. E. , Devy, L. , Hajitou, A. , Frankenne, F. , Munaut, C. , Gilles, C. , Deroanne, C. , Thompson, E. W. , Foidart, J. M. , Noel, A. MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression.
Propagación y conservación in vitro de siete especies de cactáceas del noreste del estado de Guanajuato

Protocols were developed for in vitro propagation of these seven cacti species distributed in northeast municipalities of the State of Guanajuato: Mammillaria geminispina , M. magnimamm , M. marcosii , M. mercadensi , M. petterssonii , Coryphanta radians and Ferocactus latispinus . Presence of kinetin one cytokinin, was essential for propagation of six species. The higher responses were obtained at mayor concentrations of the two grow regulators used; acido indoIacetico (IAA, for its acronym in spanish) = 4 mg/l and kinetin 10 mg/l, with average of 6.0, 6.0 and 9.2 sprouts per explant. Distinctively, Ferocactus latispinus p roduced 4.8 sprouts per explant, at the doses of IAA = 4 mg/l, in absence of kinetin, these results show variability in response to grow regulators, of different species of cacti family.
Systemic induction of salicylic acid‐related plant defences in potato in response to Rhizoctonia solani AG3PT

The necrotrophic pathogen Rhizoctonia solani affects potato (Solanum tuberosum) quality worldwide. The pathogen infects below-ground parts of potato during growth. Very little information is available on the extent of colonization of roots by R. solani AG3PT and especially on the defence responses in roots following sprout inoculation with the pathogen. It was hypothesized that infection of the primary sprout results in colonization of the roots by the pathogen, and that R. solani as a necrotroph induces jasmonic acid/ethylene (JA/ET)-related defence responses in sprouts and in the root. Seven well-described genes of general defence responses against fungal pathogens were selected for this study. The expression of these genes was investigated at the transcript level and, for four genes, at the protein level in roots and sprouts at 3, 6 and 13 days post-inoculation (dpi). In addition, the density of colonization of roots with R. solani AG3PT was analysed. Roots were quickly colonized by R. solani following sprout inoculation; however, the rapidly growing root was not further extensively colonized by the pathogen. Furthermore, an increase in transcript and protein levels of the defence-related genes associated with JA/ET(PR-2) and SA-dependent pathways (PR-1, PR-3 and PR-10) was detected in roots and sprouts at 3 and 6 dpi. However, the susceptible potato cultivar was not able to maintain the elevated transcript level of defence-related genes in roots and sprouts. The results underline that not only the JA/ ETbut also the SA-dependent pathway plays a role during interaction of the necrotrophic pathogen R. solani AG3PT with its host potato.
Research on Design Innovation Method Based on Multimodal Perception and Recognition Technology

In order to solve the problems of low efficiency and poor robustness of single-mode speech emotion recognition, this paper uses a multi-mode fusion mechanism to fuse speech and visual information across modes to build an audio-visual speech recognition (AVSR) system. The results show that the modal attention mechanism can automatically adjust to a more stable and reliable state according to the quality of a single signal, so that the audio-visual multimodal perception is accurate and the recognition efficiency is high.
Nuclear Factor- kappa B (NF-ҡB) Activation Gene Single Nucleotide Polymorphisms (SNP) Associated with the Risk of Psoriasis in Chinese Han People of Wuhan, Hubei Province

Background: Psoriasis is a chronic, life-long inflammatory disorder that primarily affects the skin. The etiopathogenesis of psoriasis remains elusive. The activation of the NF-ҡB/Rel transcription family, by nuclear translocation of cytoplasmic complexes, plays a critical role in inflammation through its ability to induce transcription of pro-inflammatory genes. This pathway is activated upon appropriate cellular stimulation, most often by signals related to pathogens or stress. Objective: To study TRAF3IP2 (rs33980500), TNFAIP3 (rs610604) and NFKBIA (rs12586317) gene activation single nucleotide polymorphisms are associated with risk of psoriasis in Chinese Han population of Wuhan city, Hubei Province. Materials and Methods: The genetic analysis included samples from 44 patients and 50 controls Original Research Article Malan et al.; AJRDES, 3(3): 46-55, 2020; Article no.AJRDES. 59323 47 was analyzed by Amplified Fragment Length Polymorphisms (AFLP System) using Applied Biosystems Gene Mapper 4.0. Results: The average age of clients was 47 years with an age range of 9–86 years and an average age of onset of 37 years. 38 were male (86.36%) and 6 (13.64%) were female, of which six patients (13.64%) had a family history of psoriasis. The psoriasis area severity index (PASI) was about 10.7 (range 3.5-24), this scale evaluates the severity of three clinical signs (erythema, induration and desquamation) on a scale from 0 to 4 (from none to maximum). However, our research on the Chinese community yielded lack of association for the SNP rs12586317, rs33980500, and rs610604 with P-values of 0.9177, 0.3482, and 0.2009, respectively. Conclusion: Genetic polymorphisms of NFKB1A (rs12586317), TRAF3IP2 (rs33980500) and TNFAIP3 (rs610604) were not associated with the susceptibility of psoriasis vulgaris in Chinese Han patients of Wuhan, Hubei province. However, the authors recommend a larger scale study.NFkB is a key regulatory element in a variety of immune and inflammatory pathways, in cellular proliferation and differentiation and in apoptosis, thus, orchestrates inflammation and other complex biological processes in cells. Drugs that act on NF-kB will be key in the treatment of most chronic dermatoses.
COVID-19 Pandemic in the World and its Relation to Human Development Index: A Global Study

: Coronaviruses are a large family and a subset of Coronaviridae that include common cold viruses and other severe diseases like severe acute respiratory syndrome (SARS-CoV), Middle East respiratory syndrome (MERS-CoV), and coronavirus disease 2019 (COVID-19). This is an ecological study based on statistics of the prevalence of coronavirus disease until 30 April 2020, based on the reports sent to the World Health Organization (WHO). This study investigates the distribution of the incidence and trend of the incidence rate of COVID-19 in countries, and its relation with the human development index (HDI) until 30 April 2020. The results showed that the most cases of coronavirus disease until the mentioned date were in the United States of America (1,003,947 cases), Spain (212,917 cases), Italy (203,591 cases), the United Kingdom (165,225 cases), and Germany (159,119 cases), in sequence. The results exhibited a significant positive correlation between the incidence of COVID-2019 and HDI in the world (r = 0.470, P < 0.0001).
Uric Acid Concentration With Risk Factors For Hypertensionwith Coronary Heart Disease Patients Who Do Moderaty Intensity Physical Exercise

Introduction: Complication of hypertension causes 45% of deaths from heart disease. Programs for improving quality of life in heart disease patients such as Cardiovascular Prevention and Rehabilitation program, usually includes one component, which is to do moderate-intensity physical exercise. previous study suggested that moderate-to-high intensity physical exercise could increase uric acid. Aim: To examine the correlation between uric acid concentration and risk factors for hypertension in patients with coronary heart disease who do moderate intensity physical exercise. Method: This was a retrospective study using data from medical records with cross-sectional design. The sampling method used purposive sampling based on subjective consideration and the availability of certain criteria. Analysis used chi-square analysis Results: The data were taken from medical records from 2012 until July 2019. Sampling, which appropriates for inclusion and exclusion criteria in Husada Utama Hospital, was 30 samples, 25 male, and 5 female. The majority of subjects in this research was 56-65 years old. The youngest was 40 years old while the oldest was 77 years old. Data analysis results showed that patients who had hypertension risk factors and increased uric acid were 17 patients (85%) and who did not have hypertension risk factors1. They did not experience an increase were seven people (70%) from the chi-square test. significant with p = 0.003 (p<0.05). Conclusion: There is a significant correlation between uric acid concentration and risk factors for hypertension in patients with coronary heart disease who do moderate-intensity physical exercise.
Operation assessment of an air-PCM unit for summer thermal comfort in a naturally ventilated building

ABSTRACT Due to the increasing energy use and greenhouse gas emissions related to HVAC applications in the residential sector, thermal energy storage with phase change materials has caught considerable attention in the last years. Their attractive storage capacity can be adapted to meet the energy needs of buildings. In this work, the design process of a prototype of an air-PCM unit is described, and the corresponding experimental tests are detailed. These experiments were carried out on a plus energy house prototype located in the Southwestern France, during the summertime of 2017. The thermal performance of this unit was assessed through indicators such as indoor air temperature, the operating time, and the Discomfort Degree Hours (DDH) within the house. The results suggest that the unit limits the indoor air temperature rise during its operation, keeping the temperature within the thermal comfort and therefore contributing to decreasing the thermal discomfort.
Discovery and investigation of 1-[4-(2-aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-piperidones as candidate antineoplastic agents: Our last 15 years study.

This review outlines the discovery and development of a novel series of 1-[4-2-aminoethoxy)phenylcarbonyl]- 3,5-bis-(benzylidene)-4-piperidones 5-8 as potential drug candidates over the last 15 years in our laboratory. Many of these compounds demonstrate excellent cytotoxic properties and are often more potent than contemporary anticancer drugs. Two highly important features of many of these molecules are first, the greater tumour-selective toxicity and second, the ability of these molecules to act as modulators of multi-drug resistance. The modes of action of some of the potent compounds are by apoptosis induction, generation of reactive oxygen species, activation of certain caspases and affecting mitochondrial functions. These molecules also display promising antimalarial and antimycobacterial properties. In a short term toxicity study, these molecules are well tolerated in mice. Structure-activity relationships, and a drug delivery system along with pharmacokinetic studies and metabolic stability of these compounds have been presented. The positive characteristics associated the series 5-8 warrants their further evaluations as candidate antineoplastic drug candidates.
A New Algorithm to Solve the Generalized Nash Equilibrium Problem

We try a new algorithm to solve the generalized Nash equilibrium problem (GNEP) in the paper. First, the GNEP is turned into the nonlinear complementarity problem by using the Karush–Kuhn–Tucker (KKT) condition. Then, the nonlinear complementarity problem is converted into the nonlinear equation problem by using the complementarity function method. For the nonlinear equation equilibrium problem, we design a coevolutionary immune quantum particle swarm optimization algorithm (CIQPSO) by involving the immune memory function and the antibody density inhibition mechanism into the quantum particle swarm optimization algorithm. Therefore, this algorithm has not only the properties of the immune particle swarm optimization algorithm, but also improves the abilities of iterative optimization and convergence speed. With the probability density selection and quantum uncertainty principle, the convergence of the CIQPSO algorithm is analyzed. Finally, some numerical experiment results indicate that the CIQPSO algorithm is superior to the immune particle swarm algorithm, the Newton method for normalized equilibrium, or the quasivariational inequalities penalty method. Furthermore, this algorithm also has faster convergence and better off-line performance.
Analisis Forensik Digital Storage pada Owncloud Drive

Penyimpanan data saat ini dapat menggunakan model Cloud. Cloud dapat di akses oleh beberapa user yang telah dibuatkan akun oleh admin. Semua aktivitas user terekam di history cloud. Tindak kejahatan dapat dilakukan dengan menghapus semua data penting yang ada pada Owncloud Drive yakni Nextcloud menggunakan salah satu admin dan menghapus histori pada cloud. Penelitian ini melakukan analis investigasi untuk mengethui siapa pelaku dan mengembalikan data yang sudah terhapus. Proses forensik digital storage pada owncloud drive (Nextcloud) dapat menggunakan metode dari National Institute of Standard and Technology (NIST) yang merupakan metode digital forensik yang digunakan secara umum oleh para peneliti di dunia. NIST dikembangkan untuk menyelesaikan simulasi kasus penyalahgunaan owncloud drive menggunakan skenario 5 akun yang terdiri dari satu admin dan user, pelaku melakukan kejahatan mengambil lalu menghapus data pada akun admin. Tahapan digital forensik NIST yakni pengumpulan data, pemeriksaan, analisis dan pelaporan. Berdasarkan proses investigasi yang dilakukan didapatkan laporan terkait pelaku kejahatan yang telah menghapus semua data penting yakni laporan keuangan, foto dokumentasi rahasia, dan beberapa data lainnya. Sebesar 75% data yang terhapus didapatkan kembali. Hasil penelitian ini juga didapatkan keterangan jejak pelaku kejahatan yang dibutuhkan sebagai barang bukti.
The Impact of Drought in Plant Metabolism: How to Exploit Tolerance Mechanisms to Increase Crop Production

Plants are often exposed to unfavorable environmental conditions, for instance abiotic stresses, which dramatically alter distribution of plant species among ecological niches and limit the yields of crop species. Among these, drought stress is one of the most impacting factors which alter seriously the plant physiology, finally leading to the decline of the crop productivity. Drought stress causes in plants a set of morpho-anatomical, physiological and biochemical changes, mainly addressed to limit the loss of water by transpiration with the attempt to increase the plant water use efficiency. The stomata closure, one of the first consistent reactions observed under drought, results in a series of consequent physiological/biochemical adjustments aimed at balancing the photosynthetic process as well as at enhancing the plant defense barriers against drought-promoted stress (e.g., stimulation of antioxidant systems, accumulation of osmolytes and stimulation of aquaporin synthesis), all representing an attempt by the plant to overcome the unfavorable period of limited water availability. In view of the severe changes in water availability imposed by climate change factors and considering the increasing human population, it is therefore of outmost importance to highlight: (i) how plants react to drought; (ii) the mechanisms of tolerance exhibited by some species/cultivars; and (iii) the techniques aimed at increasing the tolerance of crop species against limited water availability. All these aspects are necessary to respond to the continuously increasing demand for food, which unfortunately parallels the loss of arable land due to changes in rainfall dynamics and prolonged period of drought provoked by climate change factors. This review summarizes the most updated findings on the impact of drought stress on plant morphological, biochemical and physiological features and highlights plant mechanisms of tolerance which could be exploited to increase the plant capability to survive under limited water availability. In addition, possible applicative strategies to help the plant in counteracting unfavorable drought periods are also discussed.
Associative effect of monensin sodium to virginiamycin on the performance of beef steers in the initial feedlot phase

The objective was to evaluate the associative effect of monensin sodium to virginiamycin on the performance, dry matter intake, apparent digestibility and ingestive behavior of steers in the initial feedlot phase. The experiment lasted for 30 days, divided into two experimental periods. Thirty-six Angus Nellore steers, non-castrated, with a mean age of 10 months and an average weight of 300 kg, were divided into 18 pens. Animals were assigned to three treatments with six replications each, with the inclusion of the following additives: T1-monensin sodium, dose of 200 mg day-1; T2-monensin sodium, dose of 125 mg day-1 + virginiamycin, dose of 125 mg day-1; and T3-monensin sodium, dose of 200 mg day-1 + virginiamycin, dose of 125 mg day-1. All experimental procedures were previously submitted to the UNICENTRO Committee for Ethics in Animal Experimentation (CEUA), and were approved for execution (Official Letter 021/2019). The combination of monensin sodium with virginiamycin at a dose of 200 mg + 125 mg animal day-1 showed greater (P 0.05) difference in DM intake, with a mean value of 7.88 kg animal day-1. Regardless of the isolated or combined supplementation of the additives, no significant differences were detected in the analysis of the feeder and feces scores, ingestive behavior, and rectal temperature or infrared thermography during the evaluation period. The combination of monensin sodium with virginiamycin at 200 mg + 125 mg animal day-1 proved to be efficient in the initial feedlot period, determined by the greater weight gain and better feed conversion observed in this study.
Single-Cell RNA-seq Reveals a Subpopulation of Cells Underlying β Cell Expansion in the Postnatal Islets

Pancreatic β cells undergo significant expansion and maturation during human and rodent postnatal development. Here, we used single-cell RNA-seq to characterize gene expression patterns at various stages of mouse islet cell development and uncovered a population of cells that is most abundant during the early postnatal period. This cell population lacks expression of FLTP and expresses PDGF receptors. Each of these conditions have previously been associated with proliferative capacity in β cells suggesting that we have identified the proliferative competent of β cell mass expansion. The subpopulation co-express many endocrine lineage-specific genes and exhibits a downregulation of genes associated with mitochondrial oxidative phosphorylation and global protein synthesis. It has upregulated activity of genes in the Wnt, Hippo, PDGF, and Notch pathways and has a significantly higher proliferation potential than the more mature β population. We show that activity of the Notch pathway is required in postnatal β cell expansion where it serves to maintain an undifferentiated endocrine state in the polyhormonal cell population. Collectively, our study identifies a proliferative, progenitor-like cell subpopulation in the postnatal islet as the source of postnatal β cell expansion.
Role of "neuronal" gap junction proteins in regulating post-natal hippocampal neurodegeneration and neurogenesis in vitro and in vivo

Adult neural stem and progenitor cells (NPCs) are located within specific neurogenic niches, such as the subgranular zone of the dentate gyrus. Cell-cell communication through gap junction channels is believed to play an important role in embryonic neurogenesis. Connexins, the protein subunits of gap junctions, are expressed in NPCs and connexin36 (Cx36) is considered the prototypical neuronal connexin although a role in neurogenesis had yet to be assessed. Here, I examined the influence of Cx36 on NPC proliferation, specification, and survival in the hippocampus in vitro and in vivo in both wild type and Cx36 mice. Using cultured neurospheres from P0-P3 mice pup hippocampi, I show that Cx36 protein is first expressed upon engagement to a laminin matrix. Moreover, a Cx36 null mutation enhances neurogenesis under certain microenvironment conditions apparently by accelerating differentiation. Using thymidine analogs to label actively proliferating cells in uninjured mice and following kainic acid-induced seizures, I show that Cx36 deletion does not alter cell proliferation in the SGZ. However, the loss of Cx36 is neuroprotective following hippocampal injury without affecting neuroregenerative capacity. Finally, I demonstrate that the gap junction-like protein, pannexin2 (Panx2), is also expressed within mature neurons of the central nervous system (CNS) although functional channel activity and a role in neurogenesis have not elucidated. Here, I characterized the localization and morphology of Panx2 within hippocampal derived neurospheres in vitro and discovered that Panx2 exhibits a unique rod-like morphology with Type I and Type Ha NPCs. Together, these data implicate Cx36 in regulating postnatal NPC fate in the postnatal hippocampus and suggest a distinctive, regulatory role for Panx2 in neurogenesis.
A low‐insert loss and high‐return loss bandpass filter based on cut‐off rectangular waveguide for satellite communication application

This paper presents a low‐insert loss and high‐return loss bandpass filter (BPF). The proposed BPF consists of cut‐off rectangular waveguides and capacitive irises, showing an extremely low insert loss and a high return loss at 7.85‐8.5 GHz in the bandpass frequency range. The insert loss is less than 0.203 dB, the return loss is better than 30 dB and the attenuation exceeds 40 dB at 7.3 GHz and 9.05 GHz. Moreover, the fractional bandwidth of proposed BPF is 7.95%. The validity of the device was tested by comparison among experimental and simulation data; the results suggest that it is in satellite communication systems.