Miracle-dz/UniFAR-FTUs huggingface dataset:
The Profile of BCR-ABL1 Fusion Gene in Childhood Leukemia at “Dharmais” Cancer Hospital

Background: BCR-ABL1 fusion gene, which originated from t (9;22), is an important biomarker for diagnosis, therapeutic approach, and prognosis in childhood leukemia. However, there are no data in Indonesia about the profile of BCR-ABL1 fusion gene for this disease. This study intends to demonstrate the profile of the BCR-ABL1 fusion gene in childhood leukemia at “Dharmais” Cancer Hospital. Methods: This descriptive retrospective study included 79 patients with childhood leukemia who performed the BCR-ABL1 examination in “Dharmais” Cancer Hospital during 2008–2018. Demographic data, leukemia types, BCR-ABL1 examination results, and protein isoforms developed by BCR-ABL1 fusion were obtained from Cancer Registry Data. Results: Among 79 patients’ data recorded in this study, 65.8% (52/79) were male and 34.2% (27/79) were female. A total of 74.7% (59/79) patients were diagnosed with Chronic Myelogenous Leukemia (CML), 21.5% (17/79) with Acute Lymphoblastic Leukemia (ALL), and 3.8% (3/79) with Acute Myelogenous Leukemia (AML). The profile of positive BCR-ABL1 in CML patients was 72.8% (43/59). About 97.7% (42/43) of CML patients with positive BCR-ABL1 fusion gene expressed 210-kDa protein, while only 2.3% (1/43) expressed 190-kDa protein. Conclusions: This study found that, from a total of 79 respondents, 45 of them showed a positive BCR-ABL result, with details of 43 in CML and 2 in ALL. Among the total of 43 CML patients with positive BCR-ABL1, 42 (97.7%) of them expressed 210-kDa protein isoform. Further research to investigate the relationship between protein isoforms and their clinical effects may also be important to discuss. The valuable recommendation suggests that BCR-ABL1 examination should be performed for all childhood leukemia patients in Indonesia, especially for CML and ALL.
Parkinsonismo atípico: diagnóstico diferencial

Parkinson’s disease is known for many years, however, only in 1920 the neurologic community acknowledge the existence of other disorders with overlapping symptomatology, creating the need to differentiate this disorders. Nowadays, this symptomatology is known for parkinsonism and is characterized for the combination of six cardinal signs: rest tremor, rigidity, bradykinesia, loss of postural reflexes, flexed posture and motor blocks. Although Parkinson’s disease is considered the most common etiology, other causes are not rare. Hereupon, it is necessary an update on how to differentiate the diversity of etiologies. The current diagnosis criteria allow the differential diagnosis, nevertheless, the inaccuracy of diagnosis is still a relatively common finding. These dissertation goals are to make a bibliographic revision about parkinsonism diagnosis, identify new available information and to establish grid lines to help clinics to accomplish a correct differential diagnosis of parkinsonism cases.
Representation, Execution, and Interaction for Human-Robot Cognitive-Enabled Handover Tasks

—Robots presence increases to help reduce workers fatigue in factories. They are anticipated to become companions in households. Both environments can be widely different but in order to bring value to humans they need to be able to carry out tasks together with us. Teaming up with robots requires us to change our approach to building autonomous systems. A fundamental difference is the need for a form of cognition to adopt collaborative behaviors and adapt to situations while performing actions. This article focuses on human-robot handovers and describes a semantic model of the task as well as its integration in the robot reasoning, decision making, and interaction processes.
The Sensitivity and Specificity of Chicago Sky Blue (CSB) Dye in Comparisson with Potassium Hydroxide (KOH) Method for Superficial Dermatomycosis

Superficial dermatomycosis is a skin, nail and hair infection caused by fungal pathogen. Based on the pathogen, this infection can be divided into dermatophytosis, pityriasis versicolor and superficial candidiasis. The rapid and proper diagnosis is necessary to determine the initial theraphy and prevent the treatment delay. Superficial dermatomycosis diagnosis can be performed using anamnesis, physical examination or supporting investigation. The routine investigation method commonly use Potassium Hydroxide (KOH) because the KOH method is easy to be performed, rapid, simple and affordable. Chicago Sky Blue (CSB) is a dye to give a better color contrast to the fungi so the fungi would be easier to be detected. Objectives of this research is to observe the sensitivity and specifity difference of Chicago Sky Blue (CSB) dye and Potassium Hydroxide (KOH) methods for Superficial Dermatomycosis. The research was performed using cross sectional design analitical obsevation with 30 research subjects. The subjects consist of 15 superficial dermatomycosis patients and 15 non-superficial dermatomycosis patients. The samples were taken from the patients lesion swabs. The samples were checked using KOH and CSB, then observed by the medical analyst. The superficial dermatomycosis samples consist of mostly dermathophytosis (53.33%), then pityriasis versicolor (26.67%) and superficial candidiasis (20%). The sensitivity and specificity of KOH were 86.67% and 100%, respectively. The sensitivity and specificity of CSB were 93.33% and 100%, respectively. The CSB dye method has a higher sensitivity than KOH. The fungal elements are nicely dyed and more easily detected using CSB dye.
A Novel Identity-based Broadcast Authentication Scheme with Batch Verification for Wireless Sensor Networks

Message broadcasting is a fundamental data transmission service in wireless sensor networks (WSNs), which enables a great many users to join the network dynamically and spread messages. However, due to the open network environment, attackers can easily eavesdrop on traffic, inject false data messages, or modify legitimate content. So, many broadcast authentication schemes have been proposed to ensure the integrity and authenticity of messages transmitted in WSN, but these schemes suffer from higher computational overhead due to hash-to-point operation or certification management. To reduce the computational and communication costs, we first propose a novel Identity (ID)-based signature scheme with message recovery, and then construct an identity-based signature broadcast authentication scheme (ISBAS). In our scheme, the original messages do not require to be transmitted with its generated signature. Authentication process can recover the original message. Moreover, a larger number of messages can be verified simultaneously with batch verification. The security analysis indicates our scheme achieve known security requirements and the performance analysis proves it to be efficient.
Experimental Study on Anti-Tumor Effect of Dendrobium candidum Polysaccharides

OBJECTIVE To study the inhibitory effect of Dendrobium candidum polysaccharides(DP)on tumor growth(in vivo in vitro),discuss the possible mechanism of DP tumor-inhibition.METHODS The inhibitory effect of DP on tumor growth was observed in the mice models with implanted sarcoma 180(S180). Internal organ index change was analyzed in tumor-bearing mouse.The levels of IL-2 and TNF-α in serum were investigated by ELISA assay.The cyto-toxicity on human tumor cell lines(Hepatoma SMMC27721)was determined by cell counting kit-8(CCK-8)assay.RESULTS Mice sarcoma S180 in vivo and human hepatoma SMMC27721 in vitro were inhibited seriously by DP.The index of thymus and spleen and the levels of IL-2 and TNF-α in mice serum were effectively increased by DP.CONCLUSION DP has a remarked anti-tumor effect,its mechanism probably based on promotion of immune organ function and immune ability.
Sequence Analysis of Barley Stripe Mosaic Virus China Strain (BSMV-CH) RNA1

【Objective】This study was conducted to obtain the full-length cDNA of BSMV-CH RNA1, analyze its sequence and determine its phylogenetic relationship with foreign strains. 【Method】 The full-length cDNA of BSMV-CH RNA1 was obtained by RT-PCR from the total RNA extracted from the barley leaves infected by BSMV-CH, and cloned into pMD18 vector for sequencing. The sequence together with sequences of BSMV RNA1 available in Genbank were used for nucleotide identity analysis and molecular phylogenetic reconstruction. 【Result】The full-length cDNA of BSMV-CH RNA1 was 3 795 bp (AY789693) with a 5' cap in the 5'-terminal, a polyA structure and a tRNA-like structure in the 3' terminal. An open reading frame (ORF) was found in BSMV-CH RNA1. The ORF was 3 417 bp and deduced to encode the replicase with 1 138 amino acids. BSMV-CH RNA1 shares 95.4%-95.6% nucleotides identity with that of other strains, and the replicase shares 94.9%-95.2% and 96.5%-96.8% identities with that of other strains in nucleotides and amino acids, respectively. BSMV-CH RNA1 has more polyA in the 3' terminal than that of other stains. 【Conclusion】 The genetic relationship between BSMV-CH or CV42 and other strains is obviously lower than that among other strains. Though BSMV-CH and CV42 are relatively close to each other, BSMV-CH is a new strain that is different from CV42.
Option Pricing Accumulated with Operational Risk

In this paper we distinguish between operational risks depending on whether the operational risk naturally arises in the context of model risk. As the pricing model exposes itself to operational errors whenever it updates and improves its investment model and other related parameters. In this case, it is no longer optimal to implement the best model. Generally, an option is exercised in a jump-diffusion model, if the stock price either exactly hits the early exercise boundary or the price jumps into the exercise price region. However paths of the diffusion process are continuous. In this paper the impact of operational risk on the option pricing through the implementation of Mitra’s model with jump diffusion model is presented. A partial integral differential equation is derived and the impact of parameters of Merton’s model on operational risk and option value by operational value at risk measure is employed. The option values in the presence of operational risk on data set are computed and some of the results are presented.
Association of integrons and inserted gene with antibiotics resistance of 100 strains of Aclnetobacter baumannii isolates

Objective To explore the antibiotics resistance,integrons expression and antibiotics-resistant gene of Aclnetobacter baumannii isolates.Methods 100 strains of Aclnetobacter baumannii were isolated from clinical specimens.VITEK-64 system was used to identify the bacteria and test their susceptibility to 14 antibiotics.Class 1,2 and 3 integron integrase genes(intI 1,2 and 3) were detected by PCR.Inserted gene cassettes of variable regions in intI 1 positive isolates were detected with PCR combined with sequence analysis.Results Except amikacin and cefoperazone/sulbactam,the resistance rate of Aclnetobacter baumannii to other 12 antibiotics was higher than 60.0%,and multiple antibiotics-resistance rate was 88.0%. Integron integrase genes were observed in 64 of 100 strains of Aclnetobacter baumannii;all were intI 1.In integron positive strains,the resistance rate to common antibiotics was much higher than that in integron negative strains.In intI 1 positive strains,variable regions of integron were amplified in 54 of 64;three inserted gene cassettes were observed including aac(6′)-Ib-cr-arr-3-dfrA27(14 strains),aacA4-catB8-aadA1(24 strains),and aacC1-orfA-orfB-aadA1(16 strains). Conclusion Class1 integron expression is associated with multiple antibiotics resistance of Aclnetobacter baumannii in clinical isolates.This class 1 integron mainly carries gene cassettes of resistance to aminoglycosides antibiotics early used,trimethoprim and chloromycetin.
Lack of clearly defined role for anti-programmed death-(ligand) 1 therapy in epidermal growth factor receptor mutated non-small cell lung cancer.

We thank the authors who contributed thoughtful editorials to this journal in response to our phase II study evaluating pembrolizumab in epidermal growth factor receptor (EGFR)-mutant, programmed death-ligand 1 (PD-L1)+, tyrosine kinase inhibitor (TKI) naive patients with advanced non-small cell lung cancer (NSCLC). Specifically, the comments by Tay et al . , Casaluce and Gridelli, and Ward and Morgensztern, were insightful and perceptive both with respect to the interpretation of our study and the more general topic of anti-PD-(L)1 therapy in EGFR-mutant NSCLC (1-3). There are a number of issues raised by these editorials that we would like to further emphasize in this correspondence.
Comparing survey methods to assess the conservation value of a community‐managed protected area in western Tanzania

The ability of low-status protected areas under community management to achieve a conservation objective is frequently questioned, particularly in developing countries. The lack of sound, scientific-based biodiversity monitoring frequently undermines attempts to evaluate the extent to which these areas are contributing to biodiversity conservation. Based on data collected between 2008 and 2010 in a Forest Reserve under community management in western Tanzania, our study tested fives methods: camera trapping, walking line transects, vehicle transects, opportunistic encounters and indirect signs, to find the most appropriate for future monitoring. Method comparisons confirmed a higher performance of camera trapping compared to other methods for the ability to detect species. However, our results identified the need of a better survey design to ensure a sound monitoring in the future. Besides method comparisons, our study provides the first fine-scale data on mammal communities in such a low-status protected area. Combined methods allow the identification of 49 species of medium and large mammals, a surprisingly high diversity for such area. These findings outline the potential conservation value of this type of protected area and call for better biodiversity monitoring throughout complexes of protected areas of different statuses and management regimes. Resume La capacite des aires protegees de faible statut sous gestion communautaire e atteindre des objectifs de conservation est souvent remise en question, specialement dans les pays en developpement. Le manque de suivi efficace et scientifique de la biodiversite empeche souvent toute tentative d'evaluer dans quelle mesure ces aires contribuent a la conservation de la biodiversite. En se basant sur des donnees collectees entre 2008 et 2010 dans une reserve forestiere geree de facon communautaire dans l'ouest de la Tanzanie, notre etude a teste cinq methodes : pieges photographiques, transects parcourus a pied, en vehicule, rencontres opportunistes et signes indirects, afin de voir laquelle est la plus appropriee pour un suivi a venir. La comparaison des methodes a confirme que les pieges photographiques avaient de meilleures performances que les autres methodes pour pouvoir detecter les especes. Cependant, nos resultats ont identifie le besoin d'une etude mieux concue pour garantir un suivi correct a l'avenir. En plus de la comparaison des methodes, notre etude apporte les premieres donnees fines sur des communautes animales dans une aire a faible statut de protection. La combinaison des methodes a permis l'identification de 49 especes de moyens et grands mammiferes une diversite surprenante pour une telle aire. Ces resultats soulignent la valeur de conservation potentielle de ce type d'aire protegee et soulignent la necessite d' un meilleur suivi de la biodiversite dans les complexes d'aires protegees beneficiant de differents statuts et regimes de gestion.
Differential Cry toxin detection and effect on Brevicoryne brassicae and Myzus persicae feeding on artificial diet

The literature about effects of genetically modified plants expressing Cry toxins has several contrasting results regarding detection and effects of Cry toxins on aphids. To test the hypothesis that this variation could be due to a lack of controlled exposure, and not just a lack of toxicity, we used an artificial aphid rearing system to detect acquisition and examine potential effects of Cry1Ac and Cry1F on mortality and population growth rate of cabbage aphid, Brevicoryne brassicae (L.), and green peach aphid, Myzus persicae (Sulzer) (both Hemiptera: Aphididae). Using enzyme‐linked immunosorbent assay (ELISA), Cry1Ac and Cry1F were not detected in B. brassicae feeding on any of the Cry diets, whereas in M. persicae, Cry1Ac was detected in 55% of samples exposed alone or in combination with Cry1F, and Cry1F was detected in 67% of samples exposed alone or in combination with Cry1Ac. The toxins reduced the net population growth rate of M. persicae, but not of B. brassicae. For M. persicae, the reduction in growth rate was similar for Cry1Ac and Cry1F and there was no synergism from co‐feeding the aphids with both Cry toxins. The toxins had no detectable effect on survival of either aphid species. Variability in detection and effects of Cry toxins on aphids may not depend only on the presence and level of a Cry toxin in the phloem, and on differential experimental conditions as previously suggested, but may also depend on some characteristic of the aphid that remains to be determined.
Análisis de dependencias entre las variables de arquitectura empresarial empleando ecuaciones de relaciones difusas y su aplicación a la mejora de la toma de decisiones en las organizaciones

Resumen—Actualmente la Arquitectura Empresarial es una práctica que contribuye a incrementar el desempeño de la organización a través de las Tecnologías de la Información. Los constantes cambios y la complejidad a los que se enfrentan las empresas en el mundo real constituyen desafíos para los directivos que son difíciles de manejar en el entorno empresarial. La necesidad de disponer de una empresa saludable basada en la integración y la mejora continua del desempeño, demanda de instrumentos más eficientes que permitan evaluar la Arquitectura Empresarial a través de todas las dimensiones. En este trabajo se propone un instrumento formal de análisis de las principales variables que soportan la Arquitectura Empresarial de una organización. Se establece y cuantifica la relación causa-efecto existente entre ellas a partir de un conjunto de reglas de dependencia difusas generadas a partir del conocimiento entregado por un conjunto de expertos de diferentes empresas. A partir de las reglas difusas obtenidas se puede, por un lado, evaluar su correcta definición desde un punto de vista teórico; y por otro, establecer prioridades de mejora teniendo en cuenta el grado de dependencia de las variables en el sistema. Para conseguir esto empleamos las ecuaciones de relaciones difusas que, además de ayudar a tratar la incertidumbre, sirven de herramienta de apoyo para la toma decisiones y la gestión exitosa de la Arquitectura Empresarial.
Platelet-rich plasma in hamstring muscle injuries in professional soccer players. A pilot study

1 Department of Sport Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation 2 Russian National Soccer Team, Moscow, Russian Federation 3 Department of Musculoskeletal Disorders, University of Salerno School of Medicine, Surgery and Dentistry, Salerno, Italy 4 Centre for Sports and Exercise Medicine, Queen Mary University of London, London, UK 5 Institute of Science and Technology in Medicine, Keele University School of Medicine, Stoke on Trent, UK 6 Department of Orthopaedics No1, Pirogov National Medical & Surgical Center, Moscow, Russian Federation
Population genetics of Pecten maximus of the Northeast Atlantic coast

Abstract Studies on genetic differentiation of populations of the bivalve Pecten maximus have been attempted since the availability of protein electrophoresis techniques in the early 1980s. Restriction fragment analysis of PCR amplified mtDNA fragments was applied to improve the knowledge on the population genetics on the species. Samples from two Norwegian locations were compared, and no clear genetic difference was revealed among them. Data from these Norwegian populations were also compared to corresponding data from British populations, and it was concluded that they differentiate genetically. Thus the British and Norwegian scallop populations apparently belong to separate gene pools.
Molecular Detection of Some Virulence Genes in Stahpylococcusaureus Isolated from Different Human Clinical Specimens

Staphylococcus aureus is a significantbacteria in numerous simple and more severe diseases of humansbecause it possessesmanyvirulence factors which controlled byvarious genes that promoteinvention of thehost cells.A total of Ninetyisolates of Staphylococcus aureus obtained from various human clinical specimensdistributed asurine samples (30/90) (33.3%), wound swabs (28/90) (31.1%), blood samples (24/90) (26.7%)and sputum swabs (8/90) (8.9%). The clinical specimens were submitted to diagnostic microbiologylaboratories of Al-Hillah Teaching Hospital,Babylon maternity and children’s Hospital and AL-MahaweelGeneral Hospital during the interval from April to September 2019, in Babylon Governorate, Iraq.The multiplex PCR assay was achieved to identify Fourselected virulence genes such as (sea, seb, eta andtst) in S. aureus strains by using specific primers and depending from sizes of the products PCR amplicons.Each90 isolates of S.aureus in human clinicalspecimens were examined.T he results revealed that,the mostfrequent gene is sea 74 (82.2%), followed by seb gene 71(78.9%), tstgene 44 (48.9%) and etagene 32(35.6%) was reported as the least frequent detected gene.Furthermore, it was found that, the predominancetoxin genes represent the highestrate in S.aureus strainsisolated from wound swabs 85 (38.5%), followed by bloodsamples 69(31.2%), urine samples 54(24.4%) andfinally the sputum swabs 13 (5.9%).
Transforming Development Knowledge THE MILLENNIUM VILLAGES: LESSONS ON EVALUATING INTEGRATED RURAL DEVELOPMENT

Most development interventions are complex, comprising several interacting activities affecting multiple outcomes. Impact evaluations of such interventions are widespread, but the literature offers little guidance on how to assess the cost-effectiveness of such integrated projects. We review the literature that conducts cost-effectiveness analyses of multiple interventions alongside impact evaluations in lowand middle-income countries. Only seven studies are identified in areas as diverse as de-worming, school support, conditional cash transfers, early childhood development, and social funds. We find that none of the applied approaches can be effectively employed in all instances, though each of them can be applied in some special cases. Furthermore, none of the studies reviewed addresses output synergies. Given the rising numbers of impact assessments in development practice and their importance for policy, research needs to develop sound methods to assess the cost-effectiveness of integrated interventions.
Control of seedling emergence by ground cover and seed predation in relation to seed size for some old-field species

A field experiment was conducted to test whether control of seedling emergence by ground cover and seed predation depended on seed size. Sown seeds of 12 oldfield species with seed masses ranging from 0.06 to 12.2 mg were used for the test. Species response to experimental removal of ground cover and (or) to the addition of a cage to reduce seed predation was recorded. Results were used to determine the relationship between seed mass and effects of ground cover and (or) seed predation on seedling emergence. Adding a cage to reduce seed predation did not increase seedling emergence significantly for each of the four species with the smallest seeds (<0.14 mg). In contrast, seedling emergence increased significantly for each of the eight species with larger seeds (.)