Miracle-dz/UniFAR-FTUs huggingface dataset:
Numerical Investigation on Flow Characteristics and Aerodynamic Performance of a 1.5-Stage SCO2 Axial-Inflow Turbine with Labyrinth Seals

The leakage problem of supercritical carbon dioxide (SCO2) axial-inflow turbine brings great challenges to the efficiency and security of the power system. Labyrinth seals are usually utilized to improve the leakage characteristics of the blade tip. In this paper, a 1.5-stage SCO2 axial-inflow turbine is established and labyrinth seals are arranged on the top of the first stage stator and rotor blades. The effects of seal clearance, groove on seal cavity surface and circle groove shape on flow characteristics and aerodynamic performance under different pressure ratio are investigated. Increasing seal clearance can significantly weaken the turbine performance. Arranging rectangle, circle and V-shaped grooves on the seal cavity surface near the outlet of the seal gap can enhance the energy dissipation, reduce the relative leakage and improve the power and efficiency. Increasing the groove width can improve the aerodynamic performance while the effect of the groove depth is weak. The configuration where the circle groove width is 50% of the pitch of seal tooth achieves the best performance with the relative leakage of stator1 and rotor, power and efficiency of 6.04 × 10−3, 8.09 × 10−3, 3.467 MW and 86.86% respectively. With an increase in pressure ratio, the relative leakage increases firstly and then remains almost constant. The power increases while the efficiency increases firstly and then decreases, reaching the peak value under the design condition.
Fabrication of Long Range Surface Plasmon Polariton Biosensors incorporating Optical Waveguides and Encapsulated Microfluidic Channels via Wafer Bonding

A microfabricated structure incorporating optical waveguides and closed microfluidic channels is an essential component in realizing a practical long range surface plasmon polariton (LRSPP) biosensor. This has been achieved through advances in fabrication processes to realize reliable optical waveguides, and by development of a reliable wafer bonding process to create closed fluid channels. An existing process for fabrication of gold waveguides was modified by introducing ultra-shallow trenches to recess waveguides and present a planar surface for bonding. An improved fluidic channel etching process was characterized and successfully employed, yielding very smooth channel surfaces free from curtaining and grass issues. Optical performance of the complete bonded chips was demonstrated and verified using a cutback measurement method, producing an attenuation loss of 4.92 dB/mm. An alternative hot embossing process for formation of microfluidic channels on a TOPAS substrate was investigated.
Visualization of a business plan

In the investment process, business planning is viewed as the optimization of an organization’s movement towards a strategic development goal in a competitive, risk, uncertainty, and dynamic market environment. The article substantiates the relevance and relevance of a broader and more thoughtful application of visual models in a business plan for successful managerial diagnostics, comprehensive comparison of alternative solutions, increasing the effectiveness of communications and securing partnerships. Visualization helps to make a potential investor not a passive observer of the business plan development process and appraiser of the proposed business idea, but an interested and active person involved in the project discussion, helping to take a fresh look at the company's strengths and weaknesses, threats and opportunities of the environment. The author discusses the information needs of groups of influence on the project, features and information and analytical potential of each element of visual content, the main sections and aspects of the project, as objects of effective visualization, and also provides specific illustrative examples. The effective effect of graphical models is explained from the standpoint of cognitive visualization ideas, when visual information is assigned the role of an important tool not only to gain knowledge, but also to increase the effectiveness of mental operations of comparison, generalization, situational analysis, analogy, choice of actions.
Genetic characterization of a schoolgirl infection with novel reassortant H5N6 avian influenza virus.

A 10-year-old schoolgirl was laboratory confirmed infection with H5N6 subtype highly pathogenic avian influenza (HPAI) virus in Suzhou city in November, 2018 (JSSZ01). Hemagglutinin (HA) gene of this H5N6 virus belonged to 2.3. 4.4 H5 clade and the HA linkage peptide of JSSZ01 strain was RERRRKR↓GLF with multiple basic amino acids. Q226L and G228S mutations were not observed, but S128P, S137A, T160A substitutions in receptor binding sites (RBS) were discovered. Resistance mutation D198N in neuraminidase (NA) protein was also identified in this strain. Besides, 11 amino acids (59-69AAs) deletion was identified in NA stalk region. Most genes of JSSZ01 exhibited the highest identity with previous H5N6 viruses, but its PA segment sequence was highly similar to previous avian H3 viruses (Accession Number: EPI596567 or EPI590058), indicating that JSSZ01 may be generated by gene reassortment.
Psychosis-related disturbances

Approximately 50% to 80% of persons diagnosed with Alzheimer? s disease (AD) have some type of behavioral or psychiatric condition (eg, agitation, psychosis, and/or disinhibition). Agitation is defined in the context of restlessness, irritability, and resistiveness. Psychosis is recognized as a disturbance in the perception of objective reality. Disinhibition means a chronic loss of social restraint. In the case of AD, disinhibition can present as aggression, hyperactivity, and socially intrusive behavior. Such conditions can be burdensome for physicians and caregivers to manage. Consequences may include caregiver burnout or illness, patient abuse, and even institutionalization for the patient. Management of behavioral disturbances is no longer primarily handled by psychiatrists, but is now entering the realm of family practice and primary care. This article provides evaluation methods and treatment options for the aforementioned behavioral disturbances.
Field trials of phytomining and phytoremediation: A critical review of influencing factors and effects of additives

Abstract Plant-based technologies including phytomining, phytoextraction, phytodegradation, phytostabilization and phytovolatilization have drawn much attention during the last decade. To examine the feasibility of these nature-based solutions to accumulate, degrade, stabilize or volatize metal(loid)s and/or organic contaminants, an increasing number of field studies have been conducted. This review critically evaluates influencing factors in phytomining and phytoremediation approaches, including contaminant concentrations, fertilizer application and chelating agent addition, planting characteristics (e.g. plant density, seeding, cropping and harvesting methods), and soil properties (e.g. salinity, soil texture and soil pH). A proper trial design will assure the robustness of the results if these factors were taken into consideration seriously. We also summarized knowledge about additives used in field trials, especially biological waste-derived amendments such as biochar, compost, sewage sludge and manure. According to the literature reviewed, controversy remains whether these amendments can promote the plant performance. In addition, the utilization of microorganisms and transgenic plants in field trials, and the associated biosafety concerns such as horizontal gene transfer were discussed. Future research should examine the ecological risks associated with phytomining and phytoremediation (e.g. the secondary migration of contaminants due to improper handling of harvested plants). It is suggested that the results of field studies should guide commercial applications of phytomining and phytoremediation. Graphical Abstract
Extensive review of cloud resource management techniques in industry 4.0: Issue and challenges

Resource provisioning in the cloud is the most popular business model for any service provider due to profit that is based on how resources are distributed among users in Industry 4.0. Moreover, much research carried out to provide a better resource provisioning system to service providers; however, efficient resource provisioning may save the environments too. This study presents an extensive analysis of different resource provisioning systems based on concert parameters. More than 250 relative research articles have been considered for this study, out of these 125 articles has been processed for comparative analysis on the basis of different performance metrics. This study highlights the classifications of resource management techniques, objective functions, and open research challenges and issues while analyzing resource management techniques. It also provides the depth knowledge of uses of performance metrics utilization based on its classifications.
Intraperitoneal Chemotherapy in Ovarian Cancer

Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer death in women. Primary surgery, followed by adjuvant chemotherapy is the basis of treatment for this disease. A standard treatment includes primary surgery and if possible optimal debulking surgery (tumor residue of < 1 cm), followed by a chemotherapy; paclitaxel-carboplatin is the standard regimen in ovarian cancer. Given that the main method of spreading this disease is in the peritoneal cavity, the systemic chemotherapy brings about numerous complications; moreover, as the method of prescribing a drug inside the peritoneum causes a high drug concentration in the peritoneal cavity, conducting an intraperitoneal chemotherapy has been examined clinically. In cases of ovarian cancer recurrence, performing a secondary cytoreductive surgery, in addition to hyperthermic intraperitoneal chemotherapy (HIPEC), has led to a good survival among patients. Currently, studies are ongoing to better explain the effects of this treatment method compared to previous methods.
Breaking the Kolmogorov Barrier in Model Reduction of Fluid Flows

Turbulence modeling has been always a challenge, given the degree of underlying spatial and temporal complexity. In this paper, we propose the use of a partitioned reduced order modeling (ROM) approach for efficient and effective approximation of turbulent flows. A piecewise linear subspace is tailored to capture the fine flow details in addition to the larger scales. We test the partitioned ROM for a decaying two-dimensional (2D) turbulent flow, known as 2D Kraichnan turbulence. The flow is initiated using an array of random vortices, corresponding to an arbitrary energy spectrum. We show that partitioning produces more accurate and stable results than standard ROM based on a global application of modal decomposition techniques. We also demonstrate the predictive capability of partitioned ROM through an energy spectrum analysis, where the recovered energy spectrum significantly converges to the full order model’s statistics with increased partitioning. Although the proposed approach incurs increased memory requirements to store the local basis functions for each partition, we emphasize that it permits the construction of more compact ROMs (i.e., of smaller dimension) with comparable accuracy, which in turn significantly reduces the online computational burden. Therefore, we consider that partitioning acts as a converter which reduces the cost of online deployment at the expense of offline and memory costs. Finally, we investigate the application of closure modeling to account for the effects of modal truncation on ROM dynamics. We illustrate that closure techniques can help to stabilize the results in the inertial range, but over-stabilization might take place in the dissipative range.
Bioactive compounds and antioxidant activity of mangaba

The present study aimed to assess the behavior of bioactive compounds and total antioxidant activity of two mangaba varieties (H. speciosa var. gardneri and H. speciosa var. cuyabensis) during storage, in two ripening stages. The fruit were harvested from the Germplasm bank of the School of Agronomy, at two ripening stages: “mature green” (mature fruit picked from the tree) and “fallen” (ripe fruit collected from the ground). After collection, they were transported to the laboratory, washed under running water, immersed in chlorine solution at 100 mg L-1 for 10 minutes, left to dry and stored under ambient conditions (22±1ºC and 90±5% RH). The fruit were analyzed to determine ascorbic acid content, total extractable polyphenols, yellow flavonoids and antioxidant activity using ferric reducing antioxidant power (FRAP) and ABTS (2,2’-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid). Analyses were performed daily until the mangaba were unfit for sale, using 3 repetitions with 3 fruit each. The maximum conservation time was eight days for “mature green” and two days for “fallen" fruit. The cuyabensis variety exhibited greatest ascorbic acid content at both ripening stages, in addition to higher antioxidant activity, and was therefore found to have the best potential to be marketed as a “superfruit”.
Identifying and Targeting Immune Escape Mechanisms in Epstein-Barr Virus-Driven Lymphoproliferative Disease

2011; 118:600. (Oral Presentation) Martin K, Lustberg ME, Yan F, Patton JT, Porcu P, Nuovo G, Cavaliere R, Baiocchi RA. Successful treatment of Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder (PCNS-PTLD) with Zidovudine (AZT), Ganciclovir (GCV), Rituximab and Dexamethasone: a Single-Institution Case Series. Blood (ASH Annual Meeting Abstract). 2011; 118:3067. Alinari L, Yan F, Smith P, Patton JT, Quinion C, Yu B, Earl CT, Lustberg ME, Villagomez L, Hertlein EK, Byrd JC, Ayers L, Motiwala T, Majumder S, Li C, Sif S, Jacob ST, Baiocchi RA. Protein Arginine Methyltransferase 5 (PRMT5) Overexpression Is xi Essential for Epstein-Barr Virus-Driven B-Cell Transformation. Blood (ASH Annual Meeting Abstracts). 2012; 120:2378. Patton JT, Hartlage AS, Pan L, Lustberg ME, Drohan CM, Martin MF, Kinghorn AD, Caligiuri MA, Grever MR, Lucas DM, Baiocchi RA. Silvestrol Modulates Indirect AntiTumor Activity and Potentiates Immune Response to Epstein-Barr Virus-Driven Lymphoproliferative Disease. Blood. (ASH Annual Meeting Abstracts) 2013; 122:4422. Dugan J , Haverkos BM, Martin KL, Martin MF, Lustberg ME, Patton JT, Nuovo, Fengting Yan F, Cavaliere R, Kenney SC, Fingeroth J, Lozanski G, Ramos JC, Porcu P, Caligiuri MA, and Robert A. Baiocchi RA. Epstein-Barr Virus Kinase-Targeted Therapy for Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder. Blood (ASH Annual Meeting Abstracts). 2014; 124:1750 Hartlage AS, Liu T, Patton JT, Garman SL, Zhang X, Kurt H, Lozanski G, Lustberg ME, Caligiuri MA, Baiocchi RA. The Epstein-Barr Virus Lytic Protein BZLF1 As a Candidate Target Antigen for Vaccine Development. Blood (ASH Annual Meeting Abstracts). 2014; 124:4489 Patton JT, Mitchell ML, Pan L, Kinghorn AD, Grever, MR, Lucas, DM, Baiocchi, RA. Identifying and Targeting Cytotoxic Tumor-Associated Macrophages in Epstein-Barr Virus-Driven Lymphoproliferative Disease. Blood (ASH Annual Meeting Abstracts). 2014;
Dynamic On-Demand Fog Formation Offering On-the-Fly IoT Service Deployment

With the increasing number of IoT devices, fog computing has emerged, providing processing resources at the edge for the tremendous amount of sensed data and IoT computation. The advantage of the fog gets eliminated if it is not present near IoT devices. Fogs nowadays are pre-configured in specific locations with pre-defined services, which limit their diverse availabilities and dynamic service update. In this paper, we address the aforementioned problem by benefiting from the containerization and micro-service technologies to build our on-demand fog framework with the help of the volunteering devices. Our approach overcomes the current limitations by providing available fog devices with the ability to have services deployed on the fly. Volunteering devices form a resource capacity for building the fog computing infrastructure. Moreover, our framework leverages intelligent container placement scheme that produces efficient volunteers’ selection and distribution of services. An Evolutionary Memetic Algorithm (MA) is elaborated to solve our multi-objective container placement optimization problem. Real life and simulated experiments demonstrate various improvements over existing approaches interpreted by the relevance and efficiency of (1) forming volunteering fog devices near users with maximum time availability and shortest distance, and (2) deploying services on the fly on selected fogs with improved QoS.
Circulating tumor cell (CTC) as a prognostic marker in primary lung cancer.

e22041 Background: Circulating tumor cell (CTC) can be a useful marker in early diagnosis and monitoring therapeutic effects for patients with malignant tumors, but clinical significance of CTC in primary lung cancer remains unclear. We previously showed that CTC was a useful surrogate marker of distant metastasis in primary lung cancer (Clin Cancer Res 2009). In this study, we evaluated the prognostic value of CTC in the same cohort of patients. Methods: A total of 125 patients (median age, 67 years; 39 females and 86 males) with primary lung cancer (9 with small cell and 116 with non-small cell) were prospectively evaluated. At the time of enrollment into the study, 7.5 mL of peripheral blood was sampled from each patient, and an EpCAM-based detection system (CellSearch) was used for detection of CTC. CTC was detected in 38 patients (CTC-positive) and not detected in 87 patients (CTC-negative). Results: The median overall survival time (MST) and survival rate at 5 years after enrollment were significant.
Alltag und Rheuma

Zusammenfassung Für Menschen mit rheumatischen Erkrankungen ist der Alltag mit vielen Hürden versehen. Um Informationen über die Lebenssituation und die Unterstützungsmöglichkeiten für rheumakranke Menschen zu erhalten, hat die Deutsche Rheuma-Liga 2013/2014 eine Befragung bei Nichtmitgliedern (n=200) und Mitgliedern (n=325) durchgeführt. Für die Befragung wurde eine Stichprobe aus der Grundgesamtheit der Mitglieder der Landesverbände der Deutschen Rheuma-Liga und der Deutschen Vereinigung Morbus Bechterew gezogen. Die Nichtmitglieder wurden über Ärzte und Anzeigen rekrutiert. Es wurde sichergestellt, dass die befragten Mitglieder und Nichtmitglieder anteilig in Alter, Geschlecht und Diagnosen der Gesamtheit der Mitglieder der Rheuma-Liga entsprechen. In der Befragung der Deutschen Rheuma-Liga werden Familie und Partnerschaft als Ressource für Hilfe und Unterstützung bei der Krankheitsbewältigung benannt. Flexibilität im Hinblick auf die eigene Lebensplanung wird von Betroffenen als Grundvoraussetzung zur Bewältigung von steigenden funktionellen Einschränkungen erlebt. Autonomie und Selbstversorgung haben eine hohe Bedeutung für die Betroffenen. In der Befragung nannten die Betroffenen Mitglieder und Nichtmitglieder Einschränkungen durch die Erkrankung am häufigsten für den Bereich Hobbies und Sport, danach Alltag. 2013 haben immer noch mehr als ein Drittel der Befragten einen Hilfebedarf bei Haushaltsführung und Einkaufen angegeben. Von den Mitgliedern wurde dabei häufiger ein Hilfebedarf angegeben. Hilfe wird v. a. durch Mitglieder der Familie, durch Partner, Eltern, Geschwister, sowie durch Kinder und Schwiegerkinder in Anspruch genommen. Barrieren werden durch gesellschaftliche Rahmenbedingungen häufig erst produziert, z. B. durch bauliche Gegebenheiten, andere Hürden resultieren aus den krankheitsbedingten Funktionsbeeinträchtigungen und erfordern einen Ausgleich dieser Nachteile. Beides ist rechtlich in vielen Bereichen in Deutschland umfassend geregelt. Hier sollten Betroffene unterstützt werden, diese Rechte wahrzunehmen. Die Unterstützung durch den behandelnden Arzt ist dabei von hoher Bedeutung. Auch im Hinblick auf den Erhalt der Erwerbsfähigkeit kommt den behandelnden Ärzten aufgrund der Wechselwirkungen zwischen persönlichen Eigenschaften, Umweltfaktoren und den körperlichen Wirkungen der Erkrankung, die die berufliche Teilhabe beeinflussen, eine Schlüsselrolle zu.
Philosophical perspective on the humanization through a prism of the civilizing process (based on socio-anthropological ideas of N. Elias and M. Foucault)

The purpose of this publication is to considering the relationship between humanization and civilizing process, informing by Elias's and Foucault's studies. Theoretical basis of this research is founded on comparative analysis, phenomenological approach and generalization. Originality of this exploration is to the discovering of the similarities and also differences in Elias's and Foucault's viewpoints on civilizing process in the context of clarifying the basic meanings of humanization. Conclusions. As we believe one can point to some similarity in anthropological and sociocultural views of Elias and Foucault. First and foremost, both of them supported the thesis about of mutability of so-called human nature, that is, its conditionality by structural social changes. Secondly, Elias and Foucault are confident in that the history of cultures ("civilizations") is to the history of institutional struggle against human impulses and drives with a goal of their "modeling" in accordance with conventional social imperatives. Not only Elias, but also Foucault's post-structuralism call under question the civilizational interpretation of culture as such, that is any attempt to perspective on culture as a product exclusively of certain religious ideals and tradition. Elias proved convincingly that culture also depends on real social landscape, essential transformation of that does impact on essential transformation entire value system. And finally, within framework of these studies, the cultures are considered from point of view the degree of their civilizing in the sense of "humanizing", that is defined by them, first of all, as a long process of rationalization of behavioral patterns in terms of the strengthen of affective control and self-constraint, and also as cultivating a specific aversion to the pain in its both physiological and moral meanings . In other words, the attitude of society and its culture to violence is the most significant marker of the level of its civilization, hence its humanization. two great figures - they are both historical, they are both focused on the power, and on the history of what Foucault calls "the subject", and a "genealogy of subjectivity" ( Binkley, Dolan, Ernst & Wouters, 2010: 54-55 ). We can agree with their statement, namely that "for Elias these were less a problem a power, and more lin-ked to changes in the unique figurations of social groups" ( p. 67 ). But, Cas Wouters ( 2010 ), for instance, claimed that "Foucault's analysis of power and government is not sociologically precise enough, it remains philosophically vague and abstract" ( p. 73 ). In this instance, we'd like to clarify, that "vague and abstract" philosophical analysis of Foucault was related to his quite critical account of the Civilizing process that was inherent not only Foucault, but almost the entire social philosophy of 20 th century. Society")