Miracle-dz/UniFAR-FTUs huggingface dataset:
Parallel meshfree computation for parabolic equations on graphics hardware

The objective of this study is to develop a parallel algorithm of the meshfree method for solving parabolic equations. We assume that parallel computation is performed using graphics hardware, and the algorithm's design depends on the architecture of the device. The meshfree method employed in this study is the modified version of the radial point interpolation method, and the matrix assembly process in the algorithm is divided into smaller subprocesses that can be computed independently in parallel.
A note on the last new vertex visited by a random walk

A “cover tour” of a connected graph G from a vertex x is a random walk that begins at x, moves at each step with equal probability to any neighbor of its current vertex, and ends when it has hit every vertex of G. The cycle Cn is well known to have the curious property that a cover tour from any vertex is equally likely to end at any other vertex; the complete graph Kn shares this property, trivially, by symmetry. Ronald L. Graham has asked whether there are any other graphs with this property; we show that there are not. © 1993 John Wiley & Sons, Inc.
Aspects of Metabolic Plasticity in Mammals The Hibernation Continuum : Physiological and Molecular

Physiol. Soc. ESSN: 1548-9221. Visit our website at http://www.the-aps.org/. American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. ©2015 Int. Union Physiol. Sci./Am. the physiological developments. It is published bimonthly in February, April, June, August, October, and December by (formerly published as News in Physiological Science) publishes brief review articles on major Physiology by gest on A uust 1, 2016 http://physioline.physiology. org/ D ow nladed fom
The spectrum of movement disorders in Glut‐1 deficiency

To assess the spectrum of movement disorders, we reviewed video recordings and charts of 57 patients with Glut‐1 deficiency. Eighty‐nine percent of patients with Glut‐1 deficiency syndrome had a disturbance of gait. The most frequent gait abnormalities were ataxic‐spastic and ataxic. Action limb dystonia was observed in 86% of cases and mild chorea in 75%. Cerebellar action tremor was seen in 70% of patients, myoclonus in 16%, and dyspraxia in 21%. Nonepileptic paroxysmal events occurred in 28% of patients, and included episodes of ataxia, weakness, Parkinsonism and nonkinesogenic dyskinesias. The 40 patients (70%) who were on the ketogenic diet had less severe gait disturbances but more dystonia, chorea, tremor, myoclonus, dyspraxia, and paroxysmal events compared with the 17 patients on a conventional diet. Poor dietary compliance and low ketonuria appear to trigger the paroxysmal events in some patients. Gait disturbances and movement disorders are frequent in patients with Glut‐1 deficiency and are signs of chronic and intermittent pyramidal, cerebellar and extrapyramidal circuit dysfunction. These clinical symptoms reflect chronic nutrient deficiency during brain development and may be mitigated by chronic ketosis. © 2009 Movement Disorder Society
A New Fuzzy Mathematical Model in Recycling Collection Networks: A Possibilistic Approach

Focusing on the environmental issues, including the reduction of scrap and consumer residuals, along with the benefiting from the economic value during the life cycle of goods/products leads the companies to have an important competitive approach. The aim of this paper is to present a new mixed nonlinear facility locationallocation model in recycling collection networks by considering multi-echelon, multi-suppliers, multi-collection centers and multifacilities in the recycling network. To make an appropriate decision in reality, demands, returns, capacities, costs and distances, are regarded uncertain in our model. For this purpose, a fuzzy mathematical programming-based possibilistic approach is introduced as a solution methodology from the recent literature to solve the proposed mixed-nonlinear programming model (MNLP). The computational experiments are provided to illustrate the applicability of the designed model in a supply chain environment and to help the decision makers to facilitate their analysis. Keywords—Location-allocation model; recycling collection networks; fuzzy mathematical programming.
Alemtuzumab with corticosteroid minimization for pediatric deceased donor renal transplantation: A seven‐yr experience

Alemtuzumab is a monoclonal antibody targeting CD52 receptors on B and T lymphocytes and is an effective induction agent in pediatric renal transplantation. We report a seven‐yr experience using alemtuzumab induction and steroid‐free protocol in the pediatric population as safe and effective. Twenty‐one pediatric deceased donor renal transplants were performed at a single academic institution. All received induction with single‐dose alemtuzumab and were maintained on a steroid‐free protocol using TAC and MMF immunosuppression. There were 15 males and six females in the study whose ages ranged from one to 19 yr. The average follow‐up was 32 months (range from 12 to 78.2 months and median 33.7 ± 23.7 months). All patients had immediate graft function. Graft survival was 95%, and patient survival was 100%. Mean 12 and 36 months eGFR were 63.33 ± 21.01 and 59.90 ± 15.27 mL/min/1.73m2, respectively. Three patients developed acute T‐cell‐mediated rejection due to non‐adherence while no recipients developed cytomegalovirus infection, PTLD, or polyoma BK viral nephropathy. Steroid avoidance with single‐dose alemtuzumab induction provides adequate and safe immunosuppression in pediatric deceased donor renal transplant recipients receiving TAC and low‐dose MMF maintenance therapy.
Impacts of non-negligible electron trapping/detrapping on the NBTI characteristics in silicon nanowire transistors with TiN metal gates

Impacts of electron trapping/detrapping on the negative bias temperature instability (NBTI) characteristics in silicon nanowire transistors (SNWTs) with metal gates are experimentally studied in this paper. It is demonstrated that large amounts of as-grown defects, including both electron traps and hole traps, are induced by nanowire structure due to multiple surface crystal orientations of the cylinder nanowires. Quite different from conventional planar devices, both stress and recovery of NBTI in SNWTs are evidently impacted by electron trapping/detrapping behavior, due to the enhanced electrical field with cylinder surrounded gate, increased electron traps in the gate dielectrics and electron injection from metal gates. The generation of new-born trap-precursors in the gate dielectrics of SNWTs was also observed and the generation kinetics is discussed. These new-born precursors can be converted into traps after experiencing a grounded recovery phase and a pulse state, leading to additional unexpected reliability degradation of SNWTs.
Least squares optimization of a polynomial threshold for wavelet domain denoising

Wavelet based techniques have been used for a number of years to denoise signals. This paper focuses on optimizing a polynomial based non-linear threshold. This threshold has several features that make it well suited for use in optimized and adaptive frameworks. The optimization of this threshold is presented using a least squares based technique and the results are compared to two traditional wavelet threshold techniques.
An unilateral master-slave hand system with a force-controlled slave hand

We have developed a new unilateral master-slave hand system. The master system consists of a master arm which has a 3-DOF parallel link mechanism and a 3-DOF wrist mechanism, and a dataglove that is usually used for a virtual reality system. The slave system has a 6-DOF arm and a 16-DOF four-fingered hand. In general, a slave system is controlled by position with reference to a master system position. In this system, when an operator makes the slave system work on a complicated task, he must look at the slave carefully and let his arm and hand manipulate discretely. In the new master-slave system, each finger of the slave hand has a fingertip tactile sensor, and it is controlled by position and force. When an operator has knowledge of a task and handling objects and sets the slave fingertip stiffness, the operation can be performed easily by handling the master arm and hand to a rough position.
Characterizing the Effects of Caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments

ABSTRACT We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.
X‐ray diffraction evidence of collagen molecular packing and cross‐linking in fibrils of rat tendon observed by synchrotron radiation.

X‐ray diffraction patterns of fibres from 90 day (mature) rat‐tail tendons were investigated using synchrotron radiation. The specimens were kept isometric at their corresponding in vitro rest length, and effects of pH and ionic strength were studied during short X‐ray exposures. The results indicate that fibrils, equilibrated in physiological Ringer prior to exposure, have segregated lateral regions of well ordered collagen molecular packing. Lowering the ionic strength or the pH to 4.0 causes an order/disorder transition during which the fibril crystallinity decreases. At pH 3.5 a dramatic increase in the lateral swelling was observed. This effect was absent for fibres pretreated with sodium borohydride. The results are interpreted on the basis of cross‐linking phenomena whereby the aldimine cross‐link seems to be a controlling component of the lateral packing arrangement of collagen molecules.
Development of an epitope-based HIV-1 vaccine strategy from HIV-1 lipopeptide to dendritic-based vaccines

ABSTRACT Introduction: Development of a safe, effective and globally affordable Human Immunodeficiency Virus strain 1 (HIV-1) vaccine offers the best hope for future control of the HIV-1 pandemic. However, with the exception of the recent RV144 trial, which elicited a modest level of protection against infection, no vaccine candidate has shown efficacy in preventing HIV-1 infection or in controlling virus replication in humans. There is also a great need for a successful immunotherapeutic vaccine since combination antiretroviral therapy (cART) does not eliminate the reservoir of HIV-infected cells. But to date, no vaccine candidate has proven to significantly alter the natural history of an individual with HIV-1 infection. Areas covered: For over 25 years, the ANRS (France Recherche Nord&Sud Sida-HIV hépatites) has been committed to an original program combining basic science and clinical research developing an epitope-based vaccine strategy to induce a multiepitopic cellular response against HIV-1. This review describes the evolution of concepts, based on strategies using HIV-1 lipopeptides towards the use of dendritic cell (DC) manipulation. Expert commentary: Understanding the crucial role of DCs in immune responses allowed moving from the non-specific administration of HIV-1 sequences with lipopeptides to DC-based vaccines. These DC-targeting strategies should improve HIV-1 vaccine efficacy.
Bordetella holmesii: Comparison of Two Isolates from Blood and a Respiratory Sample

Interest in Bordetella holmesii is increasing, but very little is known about this bacterium, which can be isolated from both blood and respiratory samples. In this study, we compared a B. holmesii isolate from the blood sample of an adult with bacteremia with another isolate from a nasopharyngeal swab from an adult with whooping cough syndrome. Genetic analysis was carried out, targeting relevant genes, and virulence properties were studied in cellular and animal models. Our genomic analysis provided no evidence of traits specific to either blood or respiratory isolates of B. holmesii. Neither isolate was cytotoxic to human tracheal epithelial cells. Both isolates were only weakly invasive and they did not persist within epithelial cells for less than 48 h.
Comparison of stator current, axial leakage flux and instantaneous power to detect broken rotor bar faults in induction machines

This paper shows the practical demonstration of different factors that make it possible to overcome any shortcoming concerning the detection of broken rotor bar fault in the machines using the fault frequency components from the current, flux and instantaneous power signals under different levels of loading. Unlike previous studies that generally used single sensor type to detect broken rotor bar fault using current sensor at full-load conditions, or limited number of load cases, this research examines the use of multiple type sensors i.e. current, voltage, axial flux and instantaneous power to detect the broken rotor bar fault using standard fault frequencies. This paper also shows the importance to examine the variability in their amplitudes to other effects apart from load and fault severity.
HYPOGLYCEMIA IN TOLBUTAMIDE-TREATED DIABETES; REPORT OF TWO CASES WITH MEASUREMENT OF SERUM INSULIN.

THE OCCURRENCE of severe and protracted hypoglycemia in diabetic patients treated with sulfonylureas is rare. Most reported cases have been related to the administration of chlorpropamide1and only a few to tolbutamide.2Recently, data collected by Christensen et al3have called attention to the relationship of tolbutamide-induced hypoglycemia with the simultaneous administration of sulfonamide drugs. We have observed two patients with severe hypoglycemia, who both were under treatment with tolbutamide and sulfisoxazole. Furthermore, to our knowledge, there have been no reports of the measurement of serum insulin during such hypoglycemia; therefore, the following two cases are presented. Report of Cases Case 1 (PBBH-1-14-75). — An 81-year-old white woman was admitted because of an acute respiratory infection. Four previous admissions were for treatment of carcinoma of the rectosigmoid. On admission she was given 3 gm of erythromycin the first day, then 2 gm each day for seven days. Three
Edema as the presenting symptom of cystic fibrosis: difficulties in diagnosis.

Edema, hypoproteinemia, and anemia may be the presenting symptoms in young infants with cystic fibrosis (CF) of the pancreas. These symptoms are believed to be due to defective protein digestion and malabsorption secondary to trypsin and chymotrypsin deficiency, and are seen most frequently in infants fed either a soy bean formula 1 that contains a trypsin inhibitor, 2 or human milk that has a lower protein content than most commercial formulas. 3 Other causes of this symptom complex include inadequate intake of protein, decreased protein synthesis in severe liver disease, increased protein degradation in transient dysproteinemia, pseudohypoproteinemia in states of plasma volume expansion such as congestive heart failure, or when there is protein loss in the urine as in the nephrotic syndrome or into the gut in exudative enteropathy. The finding of an elevated chloride concentration in the sweat is the cornerstone of the diagnosis of CF. There have been
Genome Sequence of the Marine Janibacter Sp. Strain HTCC2649

ABSTRACT Janibacter sp. strain HTCC2649 is a novel marine member of the Actinobacteria, family Intrasporangiaceae, and is closely related to Janibacter melonis CM2104T and Knoellia sinensis HKI 0119T. The organism was isolated from a sample collected at Hydrostation S south of Bermuda by using high-throughput culturing techniques. Here we present the genome sequence of Janibacter sp. strain HTCC2649.
pfcrt Polymorphism and Chloroquine Resistance in Plasmodium falciparum Strains Isolated in Cambodia

ABSTRACT Plasmodium falciparum chloroquine resistance was first detected in Cambodia in the early sixties. Treatment with chloroquine was abandoned 20 years ago. In vitro chloroquine sensitivity monitoring indicates that all eastern Cambodian isolates were sensitive to chloroquine, whereas most isolates collected from western provinces displayed reduced susceptibility to chloroquine. This indicates that the rate of chloroquine resistance remains high and stable in this region in the absence of chloroquine pressure. Characterization of codons 72 to 78 and 218 to 220 of pfcrt revealed six distinct haplotypes, four of which had never been described. The frequency of each haplotype depended on the geographical origin of the samples. The CVIETIF//ISS haplotype was detected in 92% of western Cambodian isolates and in 11% of isolates collected from the eastern province, where CVMNKIF//ISA and CVIDTIF//ISS predominate. The detection of an intermediate haplotype from a susceptible area with 76T/220A, suggests that acquisition of chloroquine resistance might be a stepwise process, during which accumulation of point mutations modulates the response to chloroquine. The association of the K76T mutation with chloroquine resistance was not clear. The mutation was detected in resistant and susceptible samples, suggesting that additional factors are involved in chloroquine resistance. By contrast, the pfcrt D/N75E mutation was strongly associated with the in vitro chloroquine resistance in Cambodian isolates. The N86 allelic form of pfmdr1 was detected in all isolates, consistent with a poor association with resistance to chloroquine. This indicates that in vitro resistance to chloroquine was associated with accumulation of point mutations in pfcrt.
On-line adaptive neural training algorithm for an induction motor flux observer

This paper presents a new algorithm for induction motor stator flux observation. The novel procedure is based on a neural network with on-line adaptive training. The network topology is a standard multilayer perceptron (MLP) network and the training algorithm is based on sliding mode control (SMC) theory. The main characteristic of this novel observer is the adaptability of the gain (learning rate), which is obtained from sliding surface so that system stability is guaranteed. The neural network stator flux observer employed here does not require previous training or speed measurement. The on-line adaptive training algorithm for the neural network is described, as well as its application to a stator flux observer of an induction motor drive. Neural observer performance is demonstrated by simulations results
Partial discharge source discrimination using a support vector machine

Partial discharge (PD) measurements are an important tool for assessing the health of power equipment. Different sources of PD have different effects on the insulation performance of power apparatus. Therefore, discrimination between PD sources is of great interest to both system utilities and equipment manufacturers. This paper investigates the use of a wide bandwidth PD on-line measurement system consisting of a radio frequency current transducer (RFCT) sensor, a digital storage oscilloscope and a high performance personal computer to facilitate automatic PD source identification. Three artificial PD models were used to simulate typical PD sources which may exist within power system apparatus. Wavelet analysis was applied to pre-process measurement data obtained from the wide bandwidth PD sensor. This data was then processed using correlation analysis to cluster the discharges into different groups. A machine learning technique, namely the support vector machine (SVM) was then used to identify between the different PD sources. The SVM is trained to differentiate between the inherent features of each discharge source signal. Laboratory experiments where the trained SVM was tested using measurement data from the RFCT as opposed to conventional measurement data indicate that this approach has a robust performance and has great potential for use with field measurement data.
Experiences of staff in dealing with client sexuality in services for teenagers and adults with intellectual disability.

Previous studies have focused on staff attitudes to sexuality rather than their experience of dealing with sexual incidents. A self-completion questionnaire was devised in which seven scenarios were proposed relating to client sexuality (e.g. public masturbation and accusation of sexual abuse). Staff noted whether or not they had encountered this type of incident, and if so, how confident they felt (or would feel) in dealing with it, and whether or not they would enlist the help of colleagues. Questionnaires were sent to all statutory, voluntary and private service providers (including schools) within one community health and social services trust area in Northern Ireland, and 150 staff responded. Around two-thirds of staff reported having dealt with at least one of the seven incidents listed. Staff with previous experience of the incident listed, felt that they could deal with it more confidently in future, as did staff working in residential services rather than day services. The latter group of staff were more likely to enlist the help of colleagues than were residential staff. Nearly 50% of staff identified more training and clear policy guidelines as the two means of increasing their confidence in dealing with issues of client sexuality. These results highlight the need for staff training that spans agencies and results in common approaches to client sexuality. Suggestions for further research are noted.
[The expression and clinical significance of SphK1 and nuclear factor-κB p65 in human colon carcinoma].

OBJECTIVE To investigate the expression of sphingosine kinase 1 (SphK1) and NF-κB in colon carcinoma tissues and their correlation with clinicopathologic features. METHODS Sixty-six paraffin-embedded colon carcinoma samples and 66 fresh colon carcinoma samples were tested using immunohistochemistry, RT-PCR and Western blot, respectively. RESULTS In 66 fresh colon carcinoma samples, the positive rate of SphK1 and NF-κB mRNA expression were 84.85%(56/66) and 74.24% (49/66), while the positive rate of SphK1 and NF-κB protein detected by Western blot were 78.79% (52/66) and 69.70% (46/66). The positive rates were higher than those in the adjacent tissues [mRNA: 63.64% (42/66), 48.49% (32/66); protein: 57.58% (38/66), 45.45% (30/66)] and the normal mucosa [mRNA: 42.42% (28/66), 25.76% (17/66); protein: 36.36% (24/66), 24.24% (16/66)], with statistical significances (all P values < 0.05). The mean expressive levels of SphK1 and NF-κB mRNA and protein in colon carcinoma were both significantly higher than those in the adjacent tissues and the normal mucosa (mRNA: 0.55 ± 0.06 vs 0.35 ± 0.05 vs 0.25 ± 0.05, 0.75 ± 0.06 vs 0.43 ± 0.05 vs 0.30 ± 0.04; protein: 0.77 ± 0.05 vs 0.38 ± 0.06 vs 0.12 ± 0.03, 0.45 ± 0.08 vs 0.23 ± 0.05 vs 0.13 ± 0.03; all P values < 0.05). There was a close correlation between SphK1 and NF-κB expression levels (r = 0.459, P = 0.036). The results of immunohistochemistry were similar to those of RT-PCR and Western blot. Overexpression of SphK1 and NF-κB in colon carcinoma was related with depth of invasion, distant and lymph node metastasis and Dukes' stages (all P values < 0.05). The expression of SphK1 was also related with differentiation (P < 0.05). CONCLUSIONS Overexpression of SphK1 and NF-κB may be involved in the pathogenesis and progression of colon carcinoma. Moreover, SphK1 and NF-κB may be correlated with the invasion and metastasis of colon carcinoma.
The determination of relative kidney function in obstructive uropathy with 99Tcm-DMSA.

In this investigation differential kidney function studies were carried out for eight patients with obstructive uropathy and seven patients who did not suffer from obstruction. The aim of this investigation was to determine whether possible retention of 99Tcm-DMSA in the dilated system would lead to overestimation of the functional mass of an obstructed kidney. The clinical examination took place 4 and 24 h after i.v. injection of the 99Tcm-DMSA. From our results we conclude that this is not a major problem. It appeared that the 4 h values are as reliable as the 24 h values in the clinical situation.