Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance Evaluation of the KRYPTOR Compact PLUS Analyzer-Based B.R.A.H.M.S. CgA Ⅱ KRYPTOR Assay for Chromogranin A Measurement

Numerous immunoassays have been developed to measure the levels of chromogranin A (CgA), a useful biomarker for diagnosing and monitoring generally heterogeneous neuroendocrine tumors (NETs). Here, we evaluated the imprecision and linearity of three such assays: KRYPTOR (ThermoFisher Scientific), NEOLISA (EuroDiagnostica), and CgA-RIA (CisBio), using 123 samples for each assay. The correlation coefficients between the assays were 0.932 (CgA-RIA versus NEOLISA), 0.956 (KRYPTOR versus CgA-RIA), and 0.873 (NEOLISA versus KRYPTOR). KRYPTOR showed good precision, with percent coefficients of variation less than 5% for low and high concentration quality controls. Linearity was maintained over a wide concentration range. Comparison of CgA levels from three disease entities (NETs, non-NET pancreatic tumors, and prostate cancer) and healthy controls showed that patients with NETs had significantly higher CgA levels (n = 57, mean: 1.82 ± 0.43 log ng/mL) than healthy individuals (n = 20, mean: 1.51 ± 0.23 log ng/mL; p = 0.018). No other significant differences between groups were observed. All three immunoassays showed strong correlations in measured CgA levels. Because KRYPTOR operation uses a fully automated random-access system and requires shorter incubation times and smaller sample volumes, the KRYPTOR assay may improve laboratory workflow while maintaining satisfactory analytical performance.
Simple assessment of farmland soil phosphorus loss risk at county scale with high landscape heterogeneity

In order to improve the existing phosphorus index assessment methods, using the interactive evaluation index (IEI) as an auxiliary variable, the geographically weighted regression (GWR) was adopted as prediction means. A method of regional soil phosphorus risk assessment was constructed by modifying phosphorus index model (MPIM). The GWR-IEI method more accurately predicted available phosphorus (AP) and soil organic matter (SOM), and the prediction precision and goodness of fit were high. Compared with the ordinary least square (OLS) method, the relative improvement of the root mean squared errors (RMSE) with the GWR-IEI method reached 28.95% for available phosphorus predicted, while that of SOM was 21.24%. The phosphorus loss risk of most of the study area (95.29%) was moderate to low. The areas featuring an extremely high phosphorus loss accounted for merely 0.33% of the total research area. Phosphorus loss depends on the effects of many factors. Areas which have strong source or transfer factors are not necessarily high-risk areas for phosphorus loss. Only the co-occurrence of transfer and source factors leads to high risk and greater potential for phosphorus loss. The GWR-IEI-MPIM method accurately reflected the degree of risk for phosphorus at the regional scale, which provides a valuable reference for risk assessment of phosphorus. Keywords: high landscape heterogeneity, GWR, county scale, simplified assessment DOI: 10.25165/j.ijabe. 20211402.6185 Citation: Ning H R, Liu Q M, Zhang S W, Ye H C, Shen Q, Zhang W T, et al. Simple assessment of farmland soil phosphorus loss risk at county scale with high landscape heterogeneity. Int J Agric & Biol Eng, 2021; 14(2): 126–134.
Geodynamic Modeling of Lithospheric Removal and Surface Deformation: Application to Intraplate Uplift in Central Mongolia

Intraplate surface deformation is enigmatic and the underlying mechanisms responsible are not fully understood. We use thermo‐mechanical numerical modeling to explore the conditions under which lithospheric removal processes can occur and investigate the timing and amplitude of consequent surface deformation. We allow lithospheric removal to develop dynamically and self‐consistently by applying a phase transition and density jump that is hypothesized to be a consequence of metamorphic eclogitization in a thickened crust, rather than simply imposing an initial dense block. By systematically varying parameters, we test their influence and control on lithospheric removal. We confirm that a weak and dense lower crust, a hot crust‐mantle boundary, and a convergent regime are critical requirements for delamination‐style removal. We apply these results to central Mongolia, which is an ideal natural laboratory for studying intraplate surface uplift because of its high topography and location in the continental interior. We determine that the physical parameters and structure inferred in this region match the conditions for delamination. Thus, model outputs are evaluated against the available observational evidence. We find that the removal of the lithosphere by delamination can explain: the dome‐shaped topographic pattern and elevated surface; the thin lithosphere and its structure; the elevated temperature at the crust‐mantle boundary. Additionally, it is hypothesized that delamination leads to magmatism due to mantle decompression melting, consistent with intraplate volcanism. Ultimately, the results suggest that lithospheric removal by delamination is a physically plausible mechanism and a potential explanation for intraplate uplift.
Socio-ecological resilience and environmental sustainability: case of avocado from Mexico

ABSTRACT Natural science impact assessments of sustainability evidence more closely than social and business studies frameworks that the interdependent planetary boundary (PB) limits are being breached. This brings to attention environmental ecological assessments are better placed as the starting point to inform how human action or inaction as socio-economic behaviours can influence environmental management resilience, rather than the other way around. This study identifies food security as a grand challenge. A socio-ecological cosmopolitan resilience framework is conceptualised and applied to the commodity case of the avocado from Michoacán, Mexico. Social, economic and policy issues are identified and captured as multi-level influences. These impact environmental management as biodiversity, land usage and freshwater sustainability at individual, firm and governmental levels. A variety of recommended simultaneous changes that may advance system-wide sustainability are considered as cultural, moral and governance dimensions for socio-ecological resilience. Our framework is important as natural science and social norms must inform business practice at all levels for environmental sustainability.
IN-VITRO CYTOTOXICITY ACTIVITY OF MALAXIS RHEEDEI SW METHANOL EXTRACT AGAINST HELA CELL LINE AND MCF- 7 CELL LINE.

Cancer is a group of diseases caused by loss of cell cycle control. Cancer is associated with abnormal uncontrolled cell growth . The study was aimed to evaluation of the anticancer activity of the Malaxis rheedei Sw. on the HeLa cell line and MCF- 7cell line. The whole plant part of the Malaxis rheedei methanolic extract were tested for its inhibitory effect on HeLa Cell Line and MCF- 7cell line. The cytotoxicity of Malaxis rheedei on HeLa cell and MCF- 7cell line were evaluated by the MTT assay. Malaxis rheedei methanolic extract has significant cytotoxicity effect on MCF- 7cell line in concentration range between 18.75 to 300 µ g/ml by using MTT assay and study also showed that inhibitory action on HeLa cell line inconcentration range between 18.75 to 300 µ g/ml by using MTT assay. Methanol extract of the whole plant part of Malaxis rheedei was found to be 7.3%, 16.6%, 25.4%, 36.3% and 47.1%toxic in HeLa cell line and 7.9%, 13.9%, 26%, 48.4% and 66.3% toxic in MCF- 7cell line. IC50 value of Malaxis rheedei on MCF- 7cell was 167.76 µg/ml and IC50 value of Malaxis rheedei on HeLa Cell was not found by MTT assay. From the performed assay, methanol extract of these drug shows greater activity on MCF- 7cell line and little activity on HeLa cell line and that mean Malaxis rheedei can be used as anticancer activity. Keywords : Cytotoxicity Activity, MTT Assay, Malaxis rheedei Sw. , HeLa Cell Line , MCF- 7Cell Line.
A design of composite spar/shear web with ZPR honeycombs and graded structures for wind turbine blades

Abstract It is of great essence to unveil relationship between structure, mechanical properties, and application of bionic design. Targeting at alleviating the debonding failure issue in the internal structures of the wind turbine blade, the reversed-semi-reentrant (RSRE) honeycomb and the angular gradient (AG) honeycomb with zero Poisson’s ratio are considered in the design of the spar/shear web structure. Through finite element methods, the mechanical behaviors of these two types of honeycombs were compared to that of the hexagonal honeycomb. The ability of the RSRE honeycomb to reduce the shear stress on the skin–core interface is proved. The AG honeycomb also proves to have advantages in improving the shear stress distribution inside the honeycomb. Then, the RSRE honeycomb and the AG honeycomb are assembled together to build a complete model of spar/shear web structure. The results of simulations of the whole model under different loading conditions show that these two honeycombs have effectively promoted the mechanical behaviors of the whole model.
Experimental Investigation on the Flow Resistance of a Staged Fuel Injector with Thermal Protection

The multistaged rotating swirling usually adopts the staged combustion and multiple point fuel supply, which has the advantages of high efficiency and low emissions. However, the high inlet temperature rise will cause autooxidation and fuel coking. Multiple fuel circuit mutual cooling technology by using different flight conditions is an effective measure for the thermal protection of the nozzle. But the complicated fuel circuit configuration inevitably increase the flow resistance in the fuel jet. This paper presents an experimental investigation of flow resistance of a triple-stage rotating swirling nozzle, concerning the effects of various factors on total pressure loss and friction factor in nozzle fuel circuit. The factors include fuel velocity V f , i , inlet temperature T f , i , and inlet Reynolds number Re f , i . The results show that the complicated fuel-cooled structure made flow resistance of the pilot fuel circuit much bigger than the main one. Meanwhile, the empirical correlations between the friction factor and the inlet Reynolds number have been fitted, which can be the reference for engineering design.
Impact of Sodium Glucose Cotransporter 2 Inhibitors on Nonalcoholic Fatty Liver Disease Complicated by Diabetes Mellitus

Sodium glucose cotransporter 2 (SGLT2), a type of membrane protein highly expressed in the kidney, can regulate plasma glucose through the glomerular filtration process by reabsorption from the kidney. SGLT2 inhibitors, which are newly developed oral antidiabetic drugs, can play a role in liver diseases by inhibiting SGLT2‐mediated renal glucose reabsorption and inducing glycosuria. Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease, resulting in severe liver dysfunction. During the progression of NAFLD, there are some hallmark complications, including lipid metabolism disorders, inflammation induction, and hepatocyte death. Herein, we review several SGLT2 inhibitors that are capable of protecting individuals with NAFLD from severe complications by inhibiting de novo lipogenesis, oxidative responses, inflammation induction, and hepatocyte death.
Multipolar Lattice Resonances in Plasmonic Finite-Size Metasurfaces

Collective lattice resonances in regular arrays of plasmonic nanoparticles have attracted much attention due to a large number of applications in optics and photonics. Most of the research in this field is concentrated on the electric dipolar lattice resonances, leaving higher-order multipolar lattice resonances in plasmonic nanostructures relatively unexplored. Just a few works report exceptionally high-Q multipolar lattice resonances in plasmonic arrays, but only with infinite extent (i.e., perfectly periodic). In this work, we comprehensively study multipolar collective lattice resonances both in finite and in infinite arrays of Au and Al plasmonic nanoparticles using a rigorous theoretical treatment. It is shown that multipolar lattice resonances in the relatively large (up to 6400 nanoparticles) finite arrays exhibit broader full width at half maximum (FWHM) compared to similar resonances in the infinite arrays. We argue that our results are of particular importance for the practical implementation of multipolar lattice resonances in different photonics applications.
Improvement in Hydrogen Sensing Response of Zinc Oxide Doped with Platinum

In this work, the effect of Platinum (Pt) as dopant on the structural, morphological and gas sensing properties of ZnO has been discussed. ZnO and Ptdoped ZnO nanoparticles were synthesized by facile and cost effective co-precipitation technique. XRD analysis revealed the formation of hexagonal wurtzite structure for pure and doped nanostructures which was further supported by Raman studies.Raman and X-Ray photoelectron spectroscopy (XPS) investigations also reveal the presence of defects in doped samples. The morphology of the synthesised samples has been studied by field emission scanning electron microscopy (FESEM). For gas sensing characteristics the synthesized particles were applied as thick film onto an alumina substrate and tested at different operating temperatures for hydrogen gas. Among all samples, 0.05% Pt doped ZnO exhibited enhanced sensing performance towardshydrogen. The increase in sensing response is attributed to presence of defects in doped sample and the catalytic nature of platinum.
Characterization of histones and their post-translational modifications using reversed-phse high performance liquid chromatography and mass spectrometry

ii DEDICATION . iv ACKNOWLEDGMENTS . v VITA. vii LIST OF TABLES. xvii LIST OF FIGURES. xix
Alih Fungsi Mall-Apartemen Menjadi Rumah Sakit Darurat Covid-19

Dalam melaksanakan percepatan penanganan virus Covid-19 di Indonesia, Presiden Joko Widodo menginstruksikan untuk pemanfaatan Gedung-gedung yang tidak terpakai untuk dijadikan rumah sakit darurat. Pemilik Lippo Group berniat membantu pemerintah dengan mengubah Mall Plaza Mampang menjadi Rumah Sakit Siloam (rumah sakit darurat Covid-19), dimana mall tersebut terletak pada gedung yang sama dengan Apartemen Nine Residence. Dengan demikian, para penghuni apartemen tersebut merasa keberatan akan pengalihan fungsi tersebut. Hal yang menjadi fokus penulis adalah proses alih fungsi yang dilakukan oleh pemilik gedung terhadap terhadap mall-apartemen Nine Residence yang dijadikan sebagai rumah sakit darurat Covid-19 dan terkait pertanggungjawaban pemilik bangunan atas pengalihan fungsi tersebut. Pada penelitian ini menggunakan jenis penelitian yuridis normatif kemudian pendekatan yang digunakan yaitu pendekatan undang-undang serta pendekatan kasus. Sumber data yang digunakan adalah data sekunder dan cara memperoleh bahan penelitian ini yaitu dengan studi perpustakaan. Hasil penelitian ini menunjukkan bahwa proses alih fungsi yang dilakukan oleh pemilik bangunan terhadap mall-apartemen tersebut harus memenuhi persyaratan administrative dan persyaratan teknis sesuai dengan fungsi bangunan gedung, Berdasarkan Undang-Undang Rumah Susun, tidak diatur secara jelas terkait pertanggungjawaban pemilik bangunan gedung terhadap penghuni apartemen Nine Residence, namun jika terdapat kerugian yang ditimbulkan oleh alih fungsi tersebut, maka pemilik bangunan gedung harus bertanggung jawab kepada penghuni bangunan gedung.
The Effects of Celebrity Characteristics on Purchase Intentions: A Focus on Consumer Concern of Environmental Issues

Consumer awareness about environmental problems is important in guiding their purchasing decisions. The aim of this research is to validate the moderating effect of environmental concern in two relationships: between celebrity–brand congruity and attitudes toward the brand and, between celebrity–brand congruity and purchase intentions, specifically when consumers are exposed to green advertising including a celebrity endorser. The data were collected via an online survey with young North American and Chilean people. Structural equation modeling was used to test hypotheses in both samples. The results show that the only endorser characteristic relevant to the model is celebrity–brand congruity and its relationship with environmental concern (β = 0.23 for North Americans and β = 0.35 for Chileans with p < 0.05). In conclusion, the consumers evaluate congruence between celebrity and brand based on their concern about environment, then consider brand ethicality, and later brand credibility, which generates an attitude toward the brand and purchase intention. Therefore, identifying the consumers environmental concern is key to developing an effective advertisement with an appropriate celebrity. This research helps to understand the green-marketing literature in a more detailed way, due to this moderating variable capable of enhancing purchase intentions of consumers.
On the Origin of Wake‐Up and Antiferroelectric‐Like Behavior in Ferroelectric Hafnium Oxide

Ferroelectric hafnium oxide (HfO2) is considered a very prospective material for applications in integrated devices due to its considerably large spontaneous polarization and superior thickness scaling. In fact, the evolution of the ferroelectric hysteresis upon field cycling plays an important role in most applications; especially the so‐called wake‐up effect that describes the increase of remanent polarization for initial field cycling, needs a profound understanding in HfO2. Herein, the discovery of electric field–induced crystallization in hafnium oxide is reported. In addition, differences in the wake‐up behavior are addressed that finally can be categorized into five different cases, all being relevant when describing the evolution of ferroelectricity. Moreover, analysis of the temperature dependence and transmission Kikuchi diffraction provides insight into the underlying physical mechanisms of different wake‐up behavior scenarios, and proves ferroelastic switching as the origin for the observed antiferroelectric‐like behavior. This knowledge provides clear procedures of 1) how to experimentally quantify and 2) how to prepare and manufacture hafnium oxide phases for the five different wake‐up types.
Low-cost Delivery and Telepresence Robot for COVID-19 Crisis

Purpose: The ongoing COVID-19 crisis has created the need for social distancing between medical staff and patients, therefore, healthcare robotics is increasingly important as regards infectious control. The purpose of this study was to design and fabricate a remote controlled transport robot that could provide an optimum technology base for developing countries, having dual functions of telepresence and delivery operations inside or outside buildings, is easy to assemble and also easily able to be cleaned using standard chemical agents.Methods: This machine was designed and fabricated to incorporate two main functions; delivery and telepresence. The robot consists of a base frame, DC motors for driving and steering systems, actuator motor for driving wheel elevation, Wi-Fi AP/Repeater, network camera, and a necessary a back-up power system.Results: This robot can be used both indoors and outdoors. It can carry loads of more than 80 kg. The machine can cross obstacles greater than 3 cm. It can be cleaned by disinfectant agents. An actuator motor can lift the driving wheels above the surface to prevent gear damage. Conclusion: This article demonstrates the concept of a healthcare telepresence and delivery robot that can provide distancing during the present COVID-19 crisis, using optimum technology for low and middle-income countries. In the future, the researcher should consider development of the delivery controls, combined with the telepresence system using the internet of things, to improve the navigation system, the manipulator system for supporting multi-floor transportation, and also other multi-functional purposes.
On packaging and product returns in online retail—Mailing boxes or sending signals?

Considerable research on merchandise returns has looked at marketing elements of the sales process (e.g., product display) and how they influence returns. However, marketing and order fulfillment processes are temporally decoupled in remote purchase situations such as online retail. While both are intricate parts of the overall sales transaction, it is logical to believe that elements of order fulfillment may also be influential in explaining and controlling merchandise return. This study focuses on the packaging aspect of the order fulfillment process to explore how it may influence return incidents in online retail. Following insights from Signaling Theory, we propose that a product's package is a signal that communicates valuable information about the product to the buyer. We partner with an online retailer to study the outcome of a natural experiment involving product packaging during order fulfillment. Our results show that packaging influences returns, reducing them most significantly if the signaling is consistent across packaging levels.
Phase‐field formulation of a fictitious domain method for particulate flows interacting with complex and evolving geometries

A distributed Lagrange multiplier/fictitious domain method in a phase‐field formulation for the simulation of rigid bodies in incompressible fluid flow is presented. The phase‐field method yields an implicit representation of geometries and thus rigid body particulate flows within arbitrary geometries can be simulated based on a fixed Cartesian grid. Therefore, a phase‐field based collision model is introduced in order to address contact of particles with arbitrary solid structures as boundaries. In addition, grain growth within the boundary geometry can be considered leading to changes in its shape during the simulation. The method is validated on benchmark problems and a convergence study is performed. Multiple numerical experiments are carried out in order to show the methods' capability to simulate problems with differently shaped rigid bodies and particulate flows involving complex boundary geometries like foam structures.
THE FEASIBILITY OF INTEGRATING INSIGHTS FROM CHARACTER EDUCATION AND SUSTAINABILITY EDUCATION – A DELPHI STUDY

ABSTRACT Although fostering values is promoted within sustainability education (SE), many educators appear concerned or conflicted about how, or whether, to approach values education. An interdisciplinary research project sought to draw on insights from character education (CE) in order to explore the problem. Using the Delphi technique, 12 CE and SE experts were gathered, via email, to explore their perceptions regarding the feasibility of integrating theoretical/practical insights from the CE and SE fields. Experts rated their agreement and made comments on 41 statements. Fourteen statements reached ‘consensus’. Thematic analysis revealed experts’ agreement on an ethical base of SE providing practical application of CE; a perceived tension between democracy, pluralism and normativity; reservations about the individual nature of CE; the need for CE, and SE, to more actively foster awareness of self as part of nature; a desire for holistic and interdisciplinary education; concern regarding exam-driven education and agreement on the need to re-examine the purpose of education. The findings reveal common ground between the two fields, as well as indicating where differences could be bridged and misunderstandings addressed, suggesting avenues for future collaboration and potential integration – possibilities that it would be fruitful to pursue through further interdisciplinary research.