Miracle-dz/UniFAR-FTUs huggingface dataset:
Myocardial infarction with non-obstructive coronary arteries: A comprehensive review and future research directions

Acute coronary syndromes constitute a variety of myocardial injury presentations that include a subset of patients presenting with myocardial infarction with non-obstructive coronary arteries (MINOCA). This acute coronary syndrome differs from type 1 myocardial infarction (MI) regarding patient characteristics, presentation, physiopathology, management, treatment, and prognosis. Two-thirds of MINOCA subjects present ST-segment elevation; MINOCA patients are younger, are more often female and tend to have fewer cardiovascular risk factors. Moreover, MINOCA is a working diagnosis, and defining the aetiologic mechanism is relevant because it affects patient care and prognosis. In the absence of relevant coronary artery disease, myocardial ischaemia might be triggered by an acute event in epicardial coronary arteries, coronary microcirculation, or both. Epicardial causes of MINOCA include coronary plaque disruption, coronary dissection, and coronary spasm. Microvascular MINOCA mechanisms involve microvascular coronary spasm, takotsubo syndrome (TTS), myocarditis, and coronary thromboembolism. Coronary angiography with non-significant coronary stenosis and left ventriculography are first-line tests in the differential study of MINOCA patients. The diagnostic arsenal includes invasive and non-invasive techniques. Medical history and echocardiography can help indicate vasospasm or thrombosis, if one finite coronary territory is affected, or specify TTS if apical ballooning is present. Intravascular ultrasound, optical coherence tomography, and provocative testing are encouraged. Cardiac magnetic resonance is a cornerstone in myocarditis diagnosis. MINOCA is not a benign diagnosis, and its polymorphic forms differ in prognosis. MINOCA care varies across centres, and future multi-centre clinical trials with standardized criteria may have a positive impact on defining optimal cardiovascular care for MINOCA patients.
Current status of the genetic susceptibility in attenuated adenomatous polyposis

Adenomatous polyposis (AP) is classified according to cumulative adenoma number in classical AP (CAP) and attenuated AP (AAP). Genetic susceptibility is the major risk factor in CAP due to mutations in the known high predisposition genes APC and MUTYH. However, the contribution of genetic susceptibility to AAP is lower and less understood. New predisposition genes have been recently proposed, and some of them have been validated, but their scarcity hinders accurate risk estimations and prevalence calculations. AAP is a heterogeneous condition in terms of severity, clinical features and heritability. Therefore, clinicians do not have strong discriminating criteria for the recommendation of the genetic study of known predisposition genes, and the detection rate is low. Elucidation and knowledge of new AAP high predisposition genes are of great importance to offer accurate genetic counseling to the patient and family members. This review aims to update the genetic knowledge of AAP, and to expound the difficulties involved in the genetic analysis of a highly heterogeneous condition such as AAP.
Palm Prints for Infant Identification

substitute for any other safeguard, but a means of positive and permanent identification in case of disputed identity or loss of identity during hospitalization and throughout life. It may be used in coordination with prevailing technics for establishing identification. Experiments with infants' footprints have proved that they are valuable only psychologically, because they are of no reference value after the first ten days. The many fine wrinkles on the soles of the newborn infant render the patterns indistinct and make it difficult to get all the patterns necessary for a complete classification. There is wide variability in the patterns and the extent to which the sole lines run up the side of the foot and under the toes. Toe and fingerprints have proved to be impracticable because of the difficulty in securing perfect rolled prints of all ten tiny digits for classifying by the standard method. These deductions eliminate all areas except the palms on which the characteristics of the palmar papillary ridges make identifications by palm prints possible. In his manual on palm printing, Dr. Pond says:
Dynamic Changes Of Body Image And Quality Of Life In Breast Cancer Patients

Purpose Dynamic changes of body image and quality of life (QoL) in breast cancer patients were not commonly investigated. We aimed to compare the dynamic changes in QoL and body image of breast cancer survivors receiving breast-conserving surgery or total mastectomy within 5–10 years after surgery. Methods Patients with non-metastatic breast cancer who received surgery were invited to complete the World Health Organization Quality of Life–Brief (WHOQOL-BREF) questionnaire and the Body Image Scale (BIS) within 10 years after surgery. We applied kernel smoothing methods to capture the dynamic changes of the patients’ QoL and body image within 5 years after surgery. We also constructed multiple linear regression models to identify predictive factors for QoL and body image. Results A total of 581 patients were collected, and 211 of them received breast-conserving surgery. There were no statistically significant differences in QoL and body image for breast-conserving surgery versus total mastectomy, but the former showed fluctuating trends. BIS was a predictor of every item and domain in the WHOQOL-BREF in the multiple linear regression model, and explanatory of the trends of dynamic change over time. Patients without lymph node dissection seemed to have less positive feelings but were more satisfied with sexual activities. Conclusion Body image is predictive of the QoL of breast cancer patients. Dynamic changes of body image and QoL would be useful for shared decision-making regarding surgery in breast cancer patients.
Toxoplasma gondii And Neospora caninum In Brain Tissue Of Rodents In North-West Iran

Purpose Rodents live in proximity to humans and domestic animals. These creatures can serve as reservoir hosts for many zoonotic parasites; therefore, they increase the risk of human infections. The aim of this study was to investigate Toxoplasma gondii and Neospora caninum in rodents caught in Meshgin-Shahr District, Iran. Patients and methods In a cross-sectional study, brain samples were collected from 70 rodents caught in Meshgin-Shahr District during March and December 2015. The specimens were examined for exposure to T. gondii and N. caninum with molecular methods. Results Seventy rodents were caught, including 50 Meriones persicus, 11 Mus musculus and 9 Cricetulus migratorius. Thirty rodents were female and 40 were males. Using PCR (B1 gene), T. gondii was detected in 7.1% (5/70) of the rodents while N. caninum was not detected. The prevalence of Toxoplasma infection was higher in female rodents (4.28%) compared to male rodents (2.86%), but the difference was not significant. Conclusion The results showed a low risk of T. gondii and N. caninum among rodents. Finally, further research is needed to understand the role of these rodent species in the transmission of the above protozoan pathogens to humans and livestock in this area.
Talus Osteochondritis Dissecans: Treatment With Matrix-based Autologous Chondrocyte Implantation

Osteochondral lesions of the talus are a common occurrence especially in sports, occurring 6.5% of all ankle sprains. Inherently talar cartilage is unable to repair itself secondary to the lack of blood supply, and it is incapable of healing through the typical inflammatory phase. Such damage can be irreversible and lead to the onset of osteoarthritis. There are many surgical repair options for osteochondral lesion of the talus. However, a trial of conservative therapy is warranted especially because studies have shown that this does not adversely affect the outcome of the surgery. Ideally, the treatment options should focus on restoring the articular cartilage surface, normal hyaline cartridge, and improvement of patient's symptoms and function. Conventional surgical techniques, such as drilling and microfractures, try to address these goals through bone stimulation. However, these reparative techniques form disorganized fibrocartilage regenerate, which lacks the durability and many of the mechanical properties of the hyaline cartilage that normally covers the articular surfaces. In addition, poorer outcomes have been associated with lesions that are larger than 1 cm2. There have been recent advances in surgical techniques to address these issues. The autologous chondrocyte implantation and matrix-based chondrocyte implantation use cells that are harvested from the body for the repair of chondral defect. These biological approaches for the treatment of chondral defects of the talus are introduced here.
Patterns of postmeal insulin secretion in individuals with sulfonylurea-treated KCNJ11 neonatal diabetes show predominance of non-KATP-channel pathways

Objective Insulin secretion in sulfonylurea-treated KCNJ11 permanent neonatal diabetes mellitus (PNDM) is thought to be mediated predominantly through amplifying non-KATP-channel pathways such as incretins. Affected individuals report symptoms of postprandial hypoglycemia after eating protein/fat-rich foods. We aimed to assess the physiological response to carbohydrate and protein/fat in people with sulfonylurea-treated KCNJ11 PNDM. Research design and methods 5 adults with sulfonylurea-treated KCNJ11 PNDM and five age, sex and body mass index-matched controls without diabetes had a high-carbohydrate and high-protein/fat meal on two separate mornings. Insulin(i) and glucose(g) were measured at baseline then regularly over 4 hours after the meal. Total area under the curve (tAUC) for insulin and glucose was calculated over 4 hours and compared between meals in controls and KCNJ11 cases. Results In controls, glucose values after carbohydrate and protein/fat were similar (median glucose tAUC0-4h21.4 vs 19.7 mmol/L, p=0.08). In KCNJ11 cases glucose levels were higher after carbohydrate than after protein/fat (median glucose tAUC0-4h58.1 vs 31.3 mmol/L, p=0.04). These different glycemic responses reflected different patterns of insulin secretion: in controls, insulin secretion was greatly increased after carbohydrate versus protein/fat (median insulin tAUC0-4h727 vs 335 pmol/L, p=0.04), but in KCNJ11 cases insulin secretion was similar after carbohydrate and protein/fat (median insulin tAUC0-4h327 vs 378 pmol/L, p=0.50). Conclusions Individuals with sulfonylurea-treated KCNJ11 PNDM produce similar levels of insulin in response to both carbohydrate and protein/fat meals despite carbohydrate resulting in much higher glucose levels and protein/fat resulting in relatively low glucose levels. This suggests in an inability to modulate insulin secretion in response to glucose levels, consistent with a dependence on non-KATP pathways for insulin secretion. Trial registration number NCT02921906.
The Association Between Subclinical Hypothyroidism and Sleep Quality: A Population-Based Study

Background and Aim The relationship between subclinical hypothyroidism (SHYPO) and sleep quality is still unclear. Our objective was to compare the sleep quality between SHYPO patients and a control group with normal thyroid function. Methods A total of 2224 patients with SHYPO and 12,622 euthyroid (EUTH) control group patients were included in the present study. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. The sleep outcomes were compared to explore the association between SHYPO and sleep quality. Furthermore, we tried to identify the risk factors of poor sleep in SHYPO patients. Results Compared to the EUTH control patients, SHYPO patients had a higher PSQI score (6.83 ± 2.67 vs 6.64 ± 2.63, p =0.004) and a higher proportion of poor sleepers (67.09% vs 64.75%, p =0.033). Moreover, subjects with SHYPO were associated with poorer sleep (Odd Ratio (OR) 1.120, 95% Confidence Intervals (CI) 1.016 to 1.235, p =0.023), longer sleep latency (OR 1.162, 95% CI 1.053 to 1.282, p =0.003), and shorter sleep duration (OR 1.148, 95% CI 1.019 to 1.293, p =0.023) after adjusting for potential confounders. Furthermore, we found that lower age, lower body mass index, and women were risk factors for poor sleep quality in SHYPO patients. Conclusion Our findings suggest a relationship between SHYPO and poor sleep quality in a large Chinese population.
Is it time to separate EPA from DHA when using omega-3 fatty acids to protect heart and brain?

DOI:10.1097/MCO.0000000000000632 Support for high intakes of the bioactive omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosapentaenoic acid (DHA), for decreasing risks of cardiovascular diseases (CVD) began almost four decades ago. This was initiated by the publication of studies on Greenland Inuits, trials investigating effects on CVD risk factors and then the diet and reinfarction trial and GISSI-Prevenzione secondary prevention trials [1]. However, ‘negative’ trials followed, leading to controversies as to the benefits of omega-3 fatty acids in the prevention of both coronary heart diseases and stroke [2]. A 2018 Cochrane Library systematic review concluded that overall EPA and DHA have little or no effect for primary or secondary prevention of cardiovascular diseases [3]. Most clinical trials and reviews assessing the effects of omega-3 fatty acids in CVD and other conditions reported on combinations of EPA and DHA for the experimental interventions. With the recent publication of the strongly positive results of the reduction of cardiovascular events with icosapent ethyl–intervention trial (REDUCE-IT) [4] on the effects of a high dose of an ethyl ester of EPA (no DHA included) there has been a renewed enthusiasm for using omega-3 fatty acids to prevent and treat CVD affecting both heart and brain [5]. The findings of REDUCE-IT also highlight the question as to whether EPA might be more effective than DHA in preventing and/or treating CVD. Over the past 15 years, there has been increasing evidence that EPA and DHA are associated with different clinical and molecular effects. As one example, a number of studies and reviews have suggested that EPA is more effective than DHA in the treatment of depressive mood disorders [6]. Furthermore, a number of recent publications now detail differences between EPA and DHA on how they affect plasma lipids and lipoproteins, endothelial function and hemodynamics, platelet function and coagulation, blood pressure and heart rate responses, glycemic control, as well as other factors related to CVD [7–9]. REDUCE-IT and the earlier JELIS study (Japan EPA Lipid Intervention Study) [10] provide a basis for considering EPA to be more effective than DHA
Gene–environment interactions between HPA-axis genes and childhood maltreatment in depression: a systematic review

Abstract Objective: Gene–environment (GxE) interactions may comprise an important part of the aetiology of depression, and childhood maltreatment (CM), a significant stressor, has consistently been linked to depression. Hence, in this systematic review, we aimed to investigate the interaction between hypothalamus–pituitary–adrenal axis (HPA-axis) genes and CM in depression. Methods: We conducted a literature search using the Pubmed, Embase, and PsychINFO databases in adherence with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. We included studies investigating GxE interactions between HPA-axis genes [Angiotensin Converting Enzyme (ACE), Arginine Vasopressin (AVP), Corticotrophin Releasing Hormone (CRH), Corticotrophin Releasing Hormone Receptor 1 (CRHR1), Corticotrophin Releasing Hormone Receptor 2 (CRHR2), FK506 binding protein (FKBP5), Nuclear Receptor subfamily 3 group C member 1 (NR3C1), Nuclear Receptor subfamily 3 group C member 2 (NR3C2)] and CM in depression. Results: The literature search identified 159 potentially relevant studies. Following screening, 138 of these were excluded. Thus, 21 studies, investigating a total of 51 single nucleotide polymorphisms, were included in the final study. The most prevalent genes in the current study were CRHR1 and FKBP5. Significant GxE interactions were reported in seven of eight studies for CRHR1:rs110402 and CM, and in five of eight studies for FKBP5:rs1360780 and CM. In summary, our results suggest possible GxE interactions between CRHR1, FKBP5, NR3C1, and NR3C2 and CM, respectively. For the remaining genes, no relevant literature emerged. Conclusions: We find that genetic variation in four HPA-axis genes may influence the effects of CM in depression.
Sound matters: The impact of auditory deprivation on movement precision in rowing

Abstract Purpose of the study was to quantify the importance of auditory feedback for movement precision in elevated rowing task difficulty with elite athletes under normal and masked hearing conditions. It was hypothesized that rowing with masked hearing would reduce the precision of movement, particularly at the non-usual/less-preferred stroke frequencies (SF). Self-reported questionnaires helped to understand the difficulty of the task. Twenty rowers completed 2 × 1000 m-distance-blocks, each separated into 4 × 250 m, with increasing SF 18, 20, 22 24 strokes/minute once with normal and once with masked hearing. Precision was determined as the deviation between the SF target and the SF actually performed (DSF). Athletes’ subjective perception was requested before and after the experiment. A 2 (hearing condition) × 4 (SF 18, 20, 22, 24) repeated measures ANOVA showed systematically larger DSF during masked hearing for all SFs compared to the DSF in the normal hearing condition (p < .01). Further, the highest DSFs were found for SF 18 and 24 in both hearing conditions (no interaction effect). The athletes’ perception of the relevance of natural movement sounds for their rowing performance changed when evaluated before and after the experiment. Rowing without hearing was evaluated as mentally more demanding than physically. The results confirmed our initial assumptions and showed the relevance of natural auditory information for movement precision in rowing practice, even at a high level of expertise.
A case of mitoxantrone extravasation

Introduction Mitoxantrone is a chemotherapeutic agent approved for various diseases. The literature has been conflicting in classifying mitoxantrone as a vesicant or irritant. Case report We report a patient who had an extravasation of mitoxantrone. Mitoxantrone was administered in 50 ml normal saline. After mitoxantrone was completely infused, the site appeared edematous and the blue color of mitoxantrone developed beneath the skin. The patient reported pain. Management and outcome: The extravasation was treated with dexrazoxane and cold compresses. The pain improved each day. However, blistering developed five weeks later and the patient ultimately required surgical intervention for debridement and grafting. Discussion Extravasation events are rare and there are few controlled studies. Because of the similarities in chemical structures and mechanism of actions between mitoxantrone and anthracyclines, mitoxantrone extravasation is often treated similar to anthracyclines. Mitoxantrone's classification is unclear, as some literature classifies it as a vesicant and others as an irritant. Our case supports the categorization of mitoxantrone as a vesicant.
Role of patient‐centred outcomes after hospital discharge: a state‐of‐the‐art review

The traditional approach for measuring outcomes after surgery involves ascertaining whether a patient survived surgery while avoiding major complications. This approach does not capture the full spectrum of events that are meaningful to patients, especially because mortality risks after elective surgery are relatively low, and different complication types vary considerably with respect to their impact on postoperative recovery. This review discusses the application, advantages, disadvantages and select examples of patient‐centred outcomes in peri‐operative medicine. When applied appropriately, these outcomes complement traditional clinical outcomes, identify important changes in postoperative function that impact patients without discernible complications and ensure that the definition of success after surgery is more meaningful to all relevant stakeholders.
Correlation between new OCT parameters and metamorphopsia in advanced stages of epiretinal membranes

To correlate metamorphopsia provided by M‐CHARTS and ectopic inner foveal layers (EIFL) or ‘central bouquet’ abnormality (CBA) in patients with advanced stages of epiretinal membrane (ERM) following the novel Optical Coherence Tomography (OCT)‐based grading scheme.
Vis-a-Vis: Visual Exploration of Visualization Source Code Evolution

Developing an algorithm for a visualization prototype often involves the direct comparison of different development stages and design decisions, and even minor modifications may dramatically affect the results. While existing development tools provide visualizations for gaining general insight into performance and structural aspects of the source code, they neglect the central importance of result images unique to graphical algorithms. In this article, we present a novel approach that enables visualization programmers to simultaneously explore the evolution of their algorithm during the development phase together with its corresponding visual outcomes by providing an automatically updating meta visualization. Our interactive system allows for the direct comparison of all development states on both the visual and the source code level, by providing easy to use navigation and comparison tools. The on-the-fly construction of difference images, source code differences, and a visual representation of the source code structure further enhance the user’s insight into the states’ interconnected changes over time. Our solution is accessible via a web-based interface that provides GPU-accelerated live execution of C++ and GLSL code, as well as supporting a domain-specific programming language for scientific visualization.