Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of left ventricular assist device pressure-flow characteristic on exercise physiology: Assessment with a verified numerical model

Current left ventricular assist devices are designed to reestablish patient’s hemodynamics at rest but they lack the suitability to sustain the heart adequately during physical exercise. Aim of this work is to assess the performance during exercise of a left ventricular assist device with flatter pump pressure-flow characteristic and increased pressure sensitivity (left ventricular assist device 1) and to compare it to the performance of a left ventricular assist device with a steeper characteristic (left ventricular assist device 2). The two left ventricular assist devices were tested at constant rotational speed with a verified computational cardiorespiratory simulator reproducing an average left ventricular assist device patient response to exercise (EXE↑) and a left ventricular assist device patient with no chronotropic and inotropic response (EXE→). According to the results, left ventricular assist device 1 pumps a higher flow than left ventricular assist device 2 both at EXE↑ (6.3 vs 5.6 L/min) and at EXE→ (6.7 vs 6.1 L/min), thus it better unloads the left ventricle. Left ventricular assist device 1 increases the power delivered to the circulation from 0.63 W at rest to 0.67 W at EXE↑ and 0.82 W at EXE→, while left ventricular assist device 2 power shows even a minimal decrease. Left ventricular assist device 1 better sustains exercise hemodynamics and can provide benefits in terms of exercise performance, especially for patients with a poor residual left ventricular function, for whom the heart can hardly accommodate an increase of cardiac output.
Value of Cardiogoniometry in Diagnosis of Coronary Artery Disease in Patients with Suspected Stable Ischemic Heart Disease: A Systematic Review and Meta-Analysis.

Cardiogoniometry (CGM) has been proposed as a new diagnostic tool for coronary artery disease (CAD) in recent years. Although different studies have evaluated the diagnostic value of CGM in CAD diagnosis, no pooled analysis of its diagnostic accuracy has been performed so far. This study aimed to assess the value of CGM in diagnosing CAD in patients with suspected stable ischemic heart disease (SIHD). This was a systematic review and meta-analysis conducted on available literature until May 2018. Studies considered coronary angiography as the reference standard for CAD diagnosis and reported CGM diagnostic value parameters were included. No language and time restrictions for enrolling the studies were considered. Statistical analysis was performed using Meta-DiSc software.The findings of the 10 studies published in 9 articles were enrolled in the meta-analysis. Overall pooled sensitivity was 71.7% (69.1 to 74.1; Cochrane Q = 39.5; P < 0.00001; I2 = 77.3%), and pooled specificity was 78.8% (76.3 to 81.1; Cochrane Q = 37.39; P < 0.00001; I2 = 75.9%). Regarding Egger's regression test (P = 0.32), there was no published bias in the studies.It seems that CGM, as an easy-to-use and non-invasive modality, should be considered as a part of risk stratifying strategies for CAD in patients with SIHD, mainly in patients with contraindications for stress tests. However, further studies with a high quality of methodology are still needed to assess the diagnostic value of CGM for CAD in patients with suspected SIHD.
Supporting older people with multimorbidity: The care burden of home health-care assistants in Ireland

ABSTRACT The treatment burden inherent in self-managing multiple chronic conditions (multimorbidity) is recognized, but there has been little examination of the care burden experienced by paid home health-care assistants (HCAs) who support older people with multimorbidity. Focus groups were conducted with HCAs in Ireland and data were coded using a thematic analysis approach. Care burden of HCAs was linked with lack of knowledge and information, poor communication, insufficient time and resources, gaps in medication support and work-related stress. Strategies are required to reduce the care burden of HCAs, who are essential stakeholders supporting growing numbers of older people with multimorbidity.
EPHA2 Polymorphisms in Estonian Patients with Age-Related Cataract

Abstract Background: Ephrin receptors (Ephs) are tyrosine kinases that together with their ligands, ephrins, are considered important in cell–cell communication, especially during embryogenesis but also for epithelium homeostasis. Studies have demonstrated the involvement of mutations or common variants of the gene encoding Eph receptor A2 (EPHA2), in congenital cataract and in age-related cataract. This study investigated a number of disease-associated single nucleotide polymorphisms (SNPs) in EPHA2 in patients with age-related cataract. Materials and methods: The study included 491 Estonian patients who had surgery for age-related cataract, classified as nuclear, cortical, posterior subcapsular and mixed lens opacities, and 185 controls of the same ethnical origin. Seven SNPs in EPHA2 (rs7543472, rs11260867, rs7548209, rs3768293, rs6603867, rs6678616, rs477558) were genotyped using TaqMan Allelic Discrimination. Statistical analyses for single factor associations used χ2-test and logistic regression was performed including relevant covariates (age, sex and smoking). Results: In single-SNP allele analysis, only the rs7543472 showed a borderline significant association with risk of cataract (p = 0.048). Regression analysis with known risk factors for cataract showed no significant associations of the studied SNPs with cataract. Stratification by cataract subtype did not alter the results. Adjusted odds ratios were between 0.82 and 1.16 (95% confidence interval 0.61–1.60). Conclusions: The present study does not support a major role of EphA2 in cataractogenesis in an Estonian population.
Effectiveness of switching to very low nicotine content cigarettes plus nicotine patch versus reducing daily cigarette consumption plus nicotine patch to decrease dependence: An exploratory randomized trial.

BACKGROUND AND AIMS The United States Food and Drug Administration has proposed regulation to require cigarettes contain very low nicotine content (VLNC). In contrast, reducing the number of cigarettes per day (CPD) is the most common current method to reduce nicotine. This trial aims to explore whether gradually transitioning to VLNC cigarettes plus nicotine patch or reducing CPD plus nicotine patch is more effective at decreasing nicotine dependence. DESIGN A two-arm, individually randomized open label trial. SETTING Community setting, Vermont, USA PARTICIPANTS: 68 adult daily smokers (40% female) of ≥ 10 cigarettes/day who were not planning to quit in the next 30 days. INTERVENTIONS All participants smoked study cigarettes with a nicotine yield similar to most commercial cigarettes ad lib for 1 week (baseline). Participants then gradually reduced to 70%, 35%, 15% and 3% of baseline nicotine over 4 weeks by either a) transitioning to lower nicotine content cigarettes (N=36) or b) reducing the number of full nicotine cigarettes (N=32). All participants received nicotine patches. MEASUREMENTS The primary outcome was change in nicotine dependence assessed at baseline and weekly during the intervention with the Nicotine Dependence Syndrome Scale. FINDINGS Dependence declined over time for both VLNC and CPD participants but declined more for VLNC (mean decrease in z-score of 1.0) than CPD (mean decrease in z-score of 0.5) participants over time (interaction p=.018). CONCLUSIONS Transitioning to very low nicotine content cigarettes reduced nicotine dependence over a 4-week period to a greater extent than reducing cigarettes per day when both conditions were aided by nicotine patch.
Controlling tumor invasion: bevacizumab and BMP4 for glioblastoma.

AIM Bevacizumab has been reported to result in increased tumor invasion when used to treat malignant glioma. We hypothesized that BMP4 would prevent diffuse tumor infiltration induced by bevacizumab for malignant glioma in a xenograft model. METHODS Human glioblastoma (GBM) tumor cells were implanted in the striatum of immunocompromised mice. The animals were treated with bevacizumab and BMP4. Tumor growth and invasion were measured. RESULTS The bevacizumab-treated mice had increased survival compared with control animals (p = 0.02). BMP4 alone did not result in improved survival (p = 1.0). The bevacizumab (p = 0.006) and bevacizumab plus BMP4 (p = 0.006) groups demonstrated significantly decreased total tumor size compared with control. Tumor invasion was significantly decreased in the bevacizumab (p = 0.005), BMP4 (p = 0.04) alone and bevacizumab plus BMP4 (p = 0.002) groups compared with control. No synergistic effect between bevacizumab and BMP4 was observed. CONCLUSION Bevacizumab treatment did not result in diffuse infiltration of human GBM in a mouse xenograft model. BMP4 did have an independent favorable effect on GBM that was not synergistic with bevacizumab treatment.
Integrated PM Machine Design for an Aircraft EMA

This paper looks at the requirements and challenges of designing a permanent-magnet (PM) motor for a directly driven electromechanical actuator for aerospace applications. Having a directly driven system, the intermediate gearbox is eliminated, bringing advantages in terms of lower component count and reduced jamming probability. The design of a low-speed high pole number PM motor will be investigated as a potential solution. The main goals of the design are a high level of actuator integration in order to minimize weight and volume, fault tolerance, and high reliability. The design will be tailored to the requirements of a typical midspoiler actuation system for a large civil aircraft.
Sensing sociability: Individual differences in young adults' conversation, calling, texting, and app use behaviors in daily life.

Sociability as a disposition describes a tendency to affiliate with others (vs. be alone). Yet, we know relatively little about how much social behavior people engage in during a typical day. One challenge to documenting social behavior tendencies is the broad number of channels over which socializing can occur, both in-person and through digital media. To examine individual differences in everyday social behavior patterns, here we used smartphone-based mobile sensing methods (MSMs) in four studies (total N = 926) to collect real-world data about young adults' social behaviors across four communication channels: conversations, phone calls, text messages, and use of messaging and social media applications. To examine individual differences, we first focused on establishing between-person variability in daily social behavior, examining stability of and relationships among daily sensed social behavior tendencies. To explore factors that may explain the observed individual differences in sensed social behavior, we then expanded our focus to include other time estimates (e.g., times of the day, days of the week) and personality traits. In doing so, we present the first large-scale descriptive portrait of behavioral sociability patterns, characterizing the degree to which young adults engaged in social behaviors and mapping these behaviors onto self-reported personality dispositions. Our discussion focuses on how the observed sociability patterns compare to previous research on young adults' social behavior. We conclude by pointing to areas for future research aimed at understanding sociability using mobile sensing and other naturalistic observation methods for the assessment of social behavior. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Revisiting the Softmax Bellman Operator: New Benefits and New Perspective

The impact of softmax on the value function itself in reinforcement learning (RL) is often viewed as problematic because it leads to sub-optimal value (or Q) functions and interferes with the contraction properties of the Bellman operator. Surprisingly, despite these concerns, and independent of its effect on exploration, the softmax Bellman operator when combined with Deep Q-learning, leads to Q-functions with superior policies in practice, even outperforming its double Q-learning counterpart. To better understand how and why this occurs, we revisit theoretical properties of the softmax Bellman operator, and prove that $(i)$ it converges to the standard Bellman operator exponentially fast in the inverse temperature parameter, and $(ii)$ the distance of its Q function from the optimal one can be bounded. These alone do not explain its superior performance, so we also show that the softmax operator can reduce the overestimation error, which may give some insight into why a sub-optimal operator leads to better performance in the presence of value function approximation. A comparison among different Bellman operators is then presented, showing the trade-offs when selecting them.
Modelling of Early Viral Kinetics and Pegylated Interferon-α2b Pharmacokinetics in Patients with HBeAg-Positive Chronic Hepatitis B

Background Pegylated interferon α2b (PEG-IFN-α2b) is effective for the treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B, although its mechanism of action remains unclear. HBeAg loss is achieved in 36% of patients after one year of PEG-IFN-α2b treatment and combination therapy with lamivudine is not superior to PEG-IFN-α2b monotherapy. Methods Early pharmacokinetics and viral kinetics were analysed in patients treated for 52 weeks with PEG-IFN-α2b with or without lamivudine. Results After 4 weeks of treatment, there was a median viral decline of 2.94 log10 copies/ml in those treated with PEG-IFN-α2b and lamivudine and only 0.45 log10 copies/ml in the PEG-IFN-α2b monotherapy group. Peak PEG-IFN-α2b levels were reached approximately one day after administration and subsequently declined exponentially, consistent with a viral load rebound near to baseline levels at the end of the dosing period in most patients receiving PEG-IFN-α2b monotherapy. Modelling of pharmacokinetics and viral kinetics data in this group revealed that viral load was minimal 3.6 days after PEG-IFN-α2b administration, the mean maximal and mean antiviral effectiveness was 70% and 48% with a mean infected cell loss rate of 0.07 per day, while no significant biphasic decline was observed. Conclusions PEG-IFN-α2b induces a sustained response in a considerable number of patients despite limited direct antiviral activity during the first weeks of antiviral therapy.
The primary motivation of sexual homicide offenders in China: Was it for sex, power and control, anger, or money?

BACKGROUND Information on sexual homicides in China is scarce, particularly with respect to the offenders' primary motivation for the offence. AIMS Our aim was to examine how offence characteristics of sexual murderers relate to different primary motivations. METHODS The offender, victim, and offence characteristics of 67 sexual homicides, derived from police data of three regions and published case reports (1994-2017), were explored and compared according to offenders' primary motivation. RESULTS Heterosexual sexual homicides were committed by offenders who were mainly driven by power and control, sex, and anger, compared with slightly over half of those who motivated primarily by financial gain. Sexual murderers whose killing was mainly driven by sex, money, and anger were more likely to target strangers, whereas offenders who motivated primarily by power and control were more likely to target an intimate partner. Victim abduction was more frequently seen in offenders who were motivated predominantly by money than other motives. Relative to financial gain as primary motivation, sexual killers who were mainly driven by sex, power and control, and anger were more likely to mutilate their victim. IMPLICATIONS FOR PRACTICE This study adds data to a field rarely studied anywhere and hardly at all in China. Findings may offer some help for criminal investigators who need to prioritise their investigative strategies. Once the individual is convicted and sentenced, they may help direct management and/or therapeutic strategies.
Solid-State Characterization of Nevirapine

The purpose of this investigation is to characterize nevirapine from commercial samples and samples crystallized from different solvents under various conditions. The solid-state behavior of nevirapine samples was investigated using a variety of complementary techniques such as microscopy (optical, polarized, hot stage microscopy), differential scanning calorimeter, thermogravimetric analysis, Fourier transform infrared spectroscopy and powder X-ray diffractometry. The commercial samples of nevirapine had the same polymorphic crystalline form with an anhedral crystal habit. Intrinsic dissolution of nevirapine was similar for both the commercial batches. Powder dissolution showed pH dependency, with maximum dissolution in acidic pH and there was no significant effect of particle size. The samples recrystallized from different solvent systems with varying polarity yielded different crystal habits. Stirring and degrees of supersaturation influenced the size and shape of the crystals. The recrystallized samples did not produce any new polymorphic form, but weak solvates with varying crystal habit were produced. Recrystallized samples showed differences in the x-ray diffractograms. However, all the samples had the same internal crystal lattice as revealed from their similar melting points and heat of fusion. The intrinsic dissolution rate of recrystallized samples was lower than the commercial sample. It was found that the compression pressure resulted in desolvation and partial conversion of the crystal form. After compression, the recrystallized samples showed similar x-ray diffractograms to the commercial sample. Amorphous form showed slightly higher aqueous solubility than the commercial crystalline form.
Design of Approximate 2-Degree-of-Freedom controller for interleaved PFC boost converter

Making power factor and harmonics distortion of power supply better are needed. An interleaved boost converter is used for an active PFC (Power Factor Correction) for reducing ripples. In the PFC boost converter, if a duty ratio, a load resistance and an input voltage are changed, the dynamic characteristics are varied greatly. This is a prime reason of difficulty of controlling the PFC boost converter. In this paper, a robust digital controller of the interleaved PFC boost converter using an A2DOF (Approximate 2-Degree-Of-Freedom) method for keeping up high power factor and low harmonics against any load is proposed. Experimental studies using a microcontroller for the controller demonstrate that this type of digital controller is effective to improve power factor and to suppress the output voltage variation at the sudden load change and the sudden input voltage change.
Prevalence of enteropathic Escherichia coli in dogs with acute and chronic diarrhoea

Samples of faeces from 57 dogs with acute diarrhoea, 82 dogs with chronic diarrhoea, 34 clinically healthy household dogs and 88 kennelled control dogs were analysed by hybridisation, using DNA probes to detect enteropathogenic Escherichia coli (EPEc) and enterotoxigenic E coli (ETEC), verocytotoxin-producing E coli (VTEC), enterohaemorrhagic E coli (EHEC), enteroinvasive E coil (EIEc) and enteroaggregative E coli (EAggEC). Samples of duodenal juice from 60 of the 82 dogs with chronic diarrhoea were also examined. Significantly more of the dogs with diarrhoea were excreting EPEC (acute 35.1 per cent, chronic 31.7 per cent) and VTEC (acute 24.6 per cent, chronic 28 per cent) than the kennelled dogs (EPEC 17.1 per cent, VTEC 0 per cent) or the household control dogs (EPEC 6 per cent, VTEC 5.9 per cent). Enteropathic E coli was also detected in the duodenal juice of 23 of 60 (38.3 per cent) of the dogs with chronic diarrhoea. The EPEC attaching and effacing A (eaeA) gene and the verocytotoxin 1 (Vri) gene coding for vTEC were often found together. There was good agreement between in vitro studies and hybridisation for the detection of eaeA and VTri. Isolates from the dogs with diarrhoea adhered significantly more to Hep-2 cells, and vr -positive strains from the dogs with diarrhoea consistently killed more than 50 per cent of Vero cells.
Hypergeometric special solutions to additive difference Painlevé equations by Padé method

We have studied Pad\'e interpolation problems on an additive grid, related to additive difference ($d$-) Painlev\'e equations of type $E_7^{(1)}$, $E_6^{(1)}$, $D_4^{(1)}$ and $A_3^{(1)}$. By solving those problems, we can derive time evolution equations, Lax pairs of scalar type and determinant formulae of special solutions, for the corresponding $d$-Painlev\'e equations. We show how the special solutions are expressed as determinant formulae by using terminating (generalized) hypergeometric functions.
Skewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients.

OBJECTIVE Fc gamma receptors of class IIa (Fc gamma RIIa) occur in 2 allelic forms, with either a low (IIa-R131) or a high (IIa-H131) affinity for complexed IgG2 and IgG3. This polymorphism might have implications for the handling of immune complexes. Therefore, we determined the distribution of the Fc gamma RIIa allotypes in patients with systemic lupus erythematosus (SLE), with or without a history of lupus nephritis. METHODS We studied 95 unrelated white European patients with SLE, as defined by the American College of Rheumatology criteria, 50 of whom had a history of lupus nephritis, and 69 healthy white European control subjects. Fc gamma RIIa allotypes were determined by immunophenotyping of blood monocytes. RESULTS It was found that lupus nephritis was significantly associated with the "low affinity" Fc gamma RIIa R/R131 allotype and with the R131 allele, compared with healthy controls. No significant association was found upon comparison of groups with and without nephritis. CONCLUSION SLE patients with a history of lupus nephritis have an abnormal distribution of Fc gamma RIIa allotypes. Fc gamma RIIa may well play a role in the pathogenesis of lupus nephritis, since IIa-R/R131 SLE patients seem to have a higher incidence of developing this complication.
Cryptosporidium hominis Subtypes and Enterocytozoon bieneusi Genotypes in HIV‐Infected Persons in Ibadan, Nigeria

Cryptosporidium and Enterocytozoon are common opportunistic pathogens in HIV+ patients in developing countries, especially those do not have access to antiretroviral therapy. To determine the distribution of genotypes/subtypes of Cryptosporidium and Enterocytozoon bieneusi, faecal specimens were collected from 132 HIV+ persons attending a tertiary hospital in Ibadan, Nigeria. By polymerase chain reaction, eight and ten patients were identified as positive for Cryptosporidium spp. and E. bieneusi, respectively. Seven of the Cryptosporidium specimens were identified as C. hominis, while the remaining one as the new species C. viatorum recently identified in the United Kingdom. DNA sequencing of the 60‐kDa glycoprotein gene showed that the C. hominis belonged to three common subtype families: Ia (in three patients), Ib (in one patient) and Ie (in one patient). In contrast, DNA sequencing of the E. bieneusi internal transcribed spacer products showed the occurrence of genotypes associated with both humans (Peru 8 in one patient, Nig2 in two patients and a new genotype in one patient) and animals (D in one patient and Type IV in five patients). Low CD4+ cell count was identified as a risk factor for both cryptosporidiosis and microsporidiosis.