Miracle-dz/UniFAR-FTUs huggingface dataset:
Propuesta de una batería neuropsicológica de evaluación cognitiva para detectar y discriminar deterioro cognitivo leve y demencias

El diagnostico precoz y etiologico del sindrome demencial en la practica clinica sigue siendo la evaluacion neuropsicologica mediante el estudio del perfil cognitivo del paciente y el analisis cualitativo y cuantitativo de las funciones, tanto deficitarias como preservadas. En este articulo se describe una bateria neuropsicologica de evaluacion cognitiva para detectar deterioro cognitivo leve en cualquiera de sus formas clinicas y demencia, y para discriminar entre los principales perfiles del sindrome demencial en funcion de su clasificacion topografica y etiologia (frontotemporales, temporoparietales, subcorticales, corticosubcorticales y multifocales). Esta bateria se implementa en la consulta especializada de evaluacion neuropsicologica del Servicio de Neurologia del Complejo Hospitalario de Navarra. Se exponen no solo las pruebas que componen el protocolo de evaluacion, sino los modelos teoricos que se consideran mas apropiados para su interpretacion.
Is the Alternative Exchange achieving its objectives? A capital structure perspective

Orientation: Despite their significant contribution to the South African economy, the majority of small and medium enterprises (SMEs) fail because of lack of access to appropriate types of capital. The Alternative Exchange (AltX) was established to address the lack of access to equity finance for SMEs. Research purpose: This study aims to determine whether the AltX has adequately enabled access to equity finance for the firms listed thereon. Motivation for the study: This study was motivated by the apparent lack of SME access to appropriate forms of finance. By evaluating the effectiveness of the AltX, the study seeks to investigate whether further measures are required to enable access to equity finance for SMEs. Research design, approach and method: A quantitative methodology was employed and panel regression models were used to compare the levels of equity and debt of firms listed on the AltX to those listed on the Johannesburg Securities Exchange’s (JSE) main board. In this manner, the study aims to determine whether AltX firms enjoy the same level of access to capital markets as their counterparts on the JSE. Main findings: The findings indicate that firms listed on the AltX have significantly higher levels of debt than those listed on the JSE’s main board. This debt tends to be the more accessible yet risky short-term debt. Practical/managerial implications: The findings infer that despite the establishment of the AltX, SMEs still face considerable constraints to accessing equity finance and, as such, may be compelled to consider other means of raising finance. Contribution/value-add: This study contributes to the research on SMEs in South Africa and suggests that further interventions are required to enable their access to appropriate forms of finance.
THE IMPACT OF AUDIT COMMITTEE EFFECTIVENESS ON AUDIT QUALITY: EVIDENCE FROM THE MIDDLE EAST

This study examines the effect of the characteristics of the audit committee, as a tool of corporate governance, on audit quality (as measured by audit fees and type of audit agent) among insurance companies listed on the Amman Stock Exchange (ASE), Jordan. The empirical study was conducted on data of all 23 listed insurance companies for the period of 2013-2017, resulting in 115 observations. Findings of multivariate analyses indicate that companies with larger audit committees and containing a high proportion of non-executive and independent directors are more likely to incur higher audit fees and hire big four audit agents, signalling their prominent level of audit quality. In contrast, more diligent audit committees are more likely to select non-big four auditing firms requiring lower audit fees. The study contributes to the existing body of literature by focusing on the role of the audit committee in enhancing audit quality, especially where there is a lack of such study in emerging economies, especially in the Middle East. The findings of the current study could be useful for regulators and policy makers in the Middle East and Arab region, particularly when they are about to review and set guidelines for effective audit committee characteristics.
Building Reputation Through Environmental Disclosure

Stakeholder’s concern for environmental sustainability makes corporate environmental responsibility become one of the company's requirements to improve reputation. A well-managed environmental program will give some benefit for the surrounding community and also enhance the company's reputation. The purpose of this study is to explain the effect of environmental disclosure on corporate reputation and to explain whether the independent commissioner can moderate that influence. The population of this study is a manufacturing company listed on the Indonesia Stock Exchange (IDX) which received an assessment on Corporate Image Index, so the observations of this research is 80 samples. Method used for data analysis is using multiple regression test. This study uses the Corporate Image Index (CII) by Frontier Consulting Group as a measurement of the company's reputation as its novelty. The paper finds that environmental disclosure affects the company's reputation in Indonesia especially in manufacturing companies. In addition, this research proves that independent commissaries can moderate the influence of environmental disclosure against reputation. The research implications for managers are about the company's reputation can be improved through their responsibility to the environment described in the environmental disclosure.
Retinal imaging tool for assessment of the parapapillary atrophy and the optic disc

Ophthalmic diseases such as glaucoma are associated with pr ogressive changes in the structure of the optic disc (OD) and parapapillary atrophy (PPA). Thes e structural changes may therefore have relevance to other systemic diseases. The size and loca tion of OD and PPA can be used as registration landmarks for monitoring changes in featur es of the fundus of the eye. Retinal vessel evaluation, for example, can be used as a biomarker fo r the effects of multiple systemic diseases, or co-morbidities. This thesis presents the first computer-aided measuring tool that detects and quantifies the progression of PPA automatically on a 2D retinal fundus image in the presence of image noise. An automated segmentation syst em i described that can detect features of the optic nerve. Three novel approaches are expl or d that extract the PPA and OD region approximately from a 2D fundus image. The OD region is segmented using (i) a combination of active contour and morphological operations, ( ii) a modified Chan-Vese algorithm and (iii) a combination of edge detection and ellipse fitting methods. The PPA region is identified from the presence of bright pixels in the temporal zone f the OD, and segmented using a sequence of techniques, including a modified Chan-Vese app ro ch, thresholding, scanning filter and multi-seed region growing methods. The work demon strates for the first time how the OD and PPA regions can be identified and quantified from 2D fund us images using a standard fundus camera. Declaration of originality I hereby declare that the research recorded in this thesis an d the thesis itself was composed and originated entirely by myself in the School of Engineering a t The University of Edinburgh.
Self-inactivating retroviral vectors for gene therapy of X-linked severe combined immunodeficiency.

X-Linked severe combined immunodeficiency (SCID-X1) is caused by mutations in the gene encoding the common cytokine receptor gamma chain, yc, resulting in profound defects in both cellular and humoral immunity. Although allogeneic bone marrow transplantation has proved highly successful, HLA-mismatched procedures are associated with significant morbidity and mortality. This disease is therefore a good candidate for gene therapy and sustained correction of 19 SCID-X1 patients have been reported in two clinical trials. However, the occurrence of severe adverse advents in one trial has highlighted the potential side-effects of retroviral gene transfer and reinforced the need to develop safer gene therapy vectors. A series of self-inactivating (SIN) gammaretroviral and lentiviral vectors for the treatment of SCID-X1 have consequently been developed. To reduce the potential for insertional mutagenesis mediated by the duplicated viral LTR sequences, alternative internal regulatory elements have been incorporated into the vector backbone. These include both endogenous (human elongation factor la - EFS) and viral (spleen focus forming virus - SFFV) promoters. In vitro, the SIN retroviral vectors were able to regulate yc expression on the cell surface of SCID-X1 cell lines and restore the lymphoid differentiation potential of Il2rg" haematopoietic progenitor cells. Functional correction of the immunological defect in the SCID-X1 mouse model was also achieved at similar levels for the both the SIN retroviral vectors and the LTR-regulated clinical vector. To further improve upon safety, lentiviral vectors were developed incorporating the endogenous human IL2RG promoter to regulate physiological expression of yc. In vitro and in vivo analysis of the promoter indicated a degree of haematopoietic tissue specificity and restoration of functional yc-receptor complexes was achieved following transduction of a SCID-X1 T cell line with a lentiviral vector incorporating this promoter however phenotypic correction of the yc-deficient mouse was unsuccessful. These results demonstrate that SIN retroviral vectors for SCID-X1 are effective in restoration of the immune defect in the yc-deficient murine model. The SIN design together with an endogenous (EFS) promoter might provide a potentially less mutagenic but equally effective vector for gene therapy of SCID-X1.
A molecular-genetic study of Congenital Nystagmus.

Nystagmus is a disorder of eye movement characterised by irregular, uncontrolled and repetitive eye movements. It can occur in a broad spectrum of clinical situations and diseases or it may occur in isolation and an inherited disorder. Surprisingly little is known about the underlying mechanisms of ocular-motor control. Similarly, the pathophysiological mechanisms underpinning nystagmus is also poorly understood. By studying pedigrees in whom nystagmus seems to be inherited as an isolated trait (Congenital Idiopathic Nystagmus), it may be possible to identify some of the genetic causes of this disorder and subsequently understand the pathophysiology. This thesis describes a molecular genetic study of congenital nystagmus. A clinical phenotyping study is followed by linkage analysis and positional cloning. A novel nystagmus gene is investigated in a large cohort of Congenital Idiopathic Nystagmus (CIN) patients and X-inactivation studies are performed. Subsequently, cell culture and RT-PCR work is performed to study expression of this gene. Additionally a pedigree with an atypical congenital nystagmus disorder is investigated and a new mutation within a known cerebellar disease gene is identified. This work contributed to the identification of the first gene for Congenital Idiopathic Nystagmus (CIN). The first detailed temporal expression study of the FRMD7 nystagmus gene was also performed in this study which has directed further studies into the pathogenesis of CIN. Identification of a new mutation in the CACNA1A gene in a pedigree with nystagmus and subtle cerebellar signs has lead to the consideration of this gene in patients who present to hospital with isolated atypical nystagmus.
A biometric study of basal metabolism in man

Internet Archive BookReader A biometric study of basal metabolism in man. The BookReader requires JavaScript to be enabled. 1 2 A BIOMETRIC STUDY OF BASAL METABOLISM IN MAN. D.F C.D. R M. M H.Full text is available as a scanned copy of the original print version. Get a printable copy PDF file of the complete article 471K, or click on a page image below.Access. Show PDF in full window Full Text PDF. A Comparison of the Basal Metabolism of Normal Men and Women PNAS 1915 1 2 104 105. Full Text.Page 134 Rubners law that the metabolism is proportional to the superficial area of an animal. In other words, the metabolism varies as the amount of heat loss.A Biometric Study of the Basal Metabolism in Man. J, Butterfield, G, Marcus, R. Accuracy of equations to predict basal metabolic rate in older women. J Am Diet.A BIOMETRIC STUDY OF HUMAN BASAL METABOLISM. Measurements on 136 men, 103 women and 94 new-born infants have been analyzed biometrically.The estimated BMR value is multiplied by a number that corresponds to the individualss. In the monograph A Biometric Study Of Basal Metabolism In Man.Introduction: The Basal Energy Expenditure BEE is the amount of energy necessary to the human body to.
Evaluation of Allergic Hypersensitivity to 2,4-D, Malathion, and Captafol in Mice

Evaluation of Allergic Hypersensitivity to 2,4-D, Malathion, and Captafol in Mice by Janette R. Cushman, Doctor of Philosophy Utah State University, 1982 Major Professor: Joseph C. Street Department: Interdepartmental Program in Toxicology 2,4Dspecific IgE antibodies were detected in serum of BALB/c mice using the rat passive cutaneous anaphylaxis (PCA) test following the second intraperitoneal immunization wi th 1, 10 , or 100 ug of 2 , 4-D-keyhole limpet hemocyanin (KLH) conjugate administe red with aluminum hydroxide adjuvant . The groups that received 1 ug of 2 , 4D conj ugate had the highest antibody titers (geome tric mean of 60) . A paper radioallergosorbent test (PRAST) was developed for determination of 2,4-Dspecific IgE. The PRAST was equally as sensitive as and showed a positive correlation with the PCA assay. The anhydride of the diacid metabolite of malathion (MMA) coupled to KLH elicited MMA-specific IgE following secondary immunization with 10 and 100 ug and tertiary immunizations with 1, 10, and 100 ug of conjugate. The highest PCA titers (geometric means of 208 and 195) were found after three immunizations with 10 or 100 ug of conjugate, respectively. A PRAST for MMAspecific
Análisis de calidad del agua para uso recreacional en la microcuenca del Arroyo Cuñapirú (Rivera, Uruguay)

La calidad de los cursos de agua depende de las variables ambientales, componentes de las cuencas y efectos antrópicos. Debido a que los sistemas fluviales son un importante recurso para la vida humana es imprescindible controlar la emisión de contaminantes, así como también realizar evaluaciones sistemáticas. La introducción de agentes extraños provenientes de la actividad humana, puede modificar los ecosistemas alterando la calidad del agua. El presente trabajo comparó la calidad del agua de 15 estaciones de muestreo en el Arroyo Cuñapirú, cuantificando variables microbiológicas y parámetros fisicoquímicos. Las variables microbiológicas arrojaron valores elevados de coliformes fecales en la mayor parte de los muestreos, lo que indicó aportes elevados de nutrientes. Se apreció una correlación positiva entre la conductividad, oxígeno disuelto, nitratos y sulfatos (primer componente principal). Nuestros resultados evidencian la necesidad de una visión integral, multivariada, con el fin de comprender los efectos de las actividades humanas sobre los ecosistema. Con este enfoque fue posible evaluar la calidad del agua con fines recreativos en la micro cuenca del Arroyo Cuñapirú.
RedR: effective support in response to changing humanitarian needs

Case studies from 20 years of RedR's humanitarian experience are presented to demonstrate recent evolutions in technologies and management systems appropriate for the effective relief of suffering during and after major disasters. Trends identified include increasing urbanisation of humanitarian response, greater demand for professionalisation and for professional infrastructure services and roles for support organisations such as RedR in developing and promoting effective relief through resource development and learning support at all levels. RedR's 2,500 peer-reviewed members worldwide form a significant professional humanitarian expertise network that can assist in coordination of humanitarian response. Field training courses provide neutral venues for frank exchange of experiences, which must be regularly captured in publications such as Engineering in Emergencies.
Measuring outcome after stroke

Stroke is the second most common cause of death worldwide. However stroke is not invariably fatal and survivors may experience major physical, social and psychological problems. The United Kingdom government identified the improvement of the quality of life of stroke survivors as a key objective in the recent "Health of the Nation" consultative document. The concept of health related quality of life has developed over the past few years. Although there is no one universally agreed definition, there are several instruments which claim to measure at least some aspects of health related quality of life. These instruments have not been extensively tested in stroke patients, so the hypothesis which I shall test in this thesis is as follows: that a simple instrument can prove a feasible, valid, reliable, and clinically useful measure of health related quality of life in stroke survivors. I selected a simple measure of health related quality of life (the EuroQol questionnaire) and evaluated its validity in a sample of patients with stroke. A small, but important proportion of patients were unable to complete EuroQol questionnaires either by themselves or by interview, so I investigated whether a proxy (e. g. a spouse or carer) could assess the patient's health status after stroke accurately and without bias. Previous studies comparing one or more different health status instruments did not involve strictly random allocation, so could not provide reliable information on the "best" measure of quality of life to use in stroke patients. I therefore performed a study in a sample of survivors of stroke which directly compared the EuroQol and SF36 by using a strict random allocation of questionnaires. It was not possible to compare quantitatively the reliability and validity of the EuroQol and SF-36; however, a qualitative comparison suggested their reliability was similar and they appeared to be sampling broadly the same areas of health.
Theoretical and experimental behavior of suspension pressurized metered dose inhalers

22 SECTION 1 OVERVIEW OF PRESSURIZED METERED DOSE INHALERS . 24 CHAPTER 1 INTRODUCTION TO PRESSURIZED METERED DOSE INHALERS . 27 Summary . 27 1. Inhalation Drug Delivery . 28 2. What are pMDIs? 30 3. In Vitro Product Performance Metrics for pMDIs . 36 4. Quality of pMDIs by Design. 38 CHAPTER 2 ADVANCES IN METERED DOSE INHALER TECHNOLOGY: HARDWARE DEVELOPMENT . 40 Summary . 40
Cerebrovascular accident in β‐thalassemia major (β‐TM) and β‐thalassemia intermedia (β‐TI)

Chronic hypercoagulable state expressed clinically by thromboembolic events has been described in thalassemia. One of the affected organs is the brain where symptomatic and asymptomatic damage has been reported. The present report describes seven cases who presented with the signs of cerebrovascular accident (CVA), five ischemic and two with hemorrhage. Two of them died. All patients were splenectomized, five received regular blood transfusions, and their ferritin levels were between 1,200 and 3,000 mg %. In addition, four patients had congestive heart failure and atrial fibrillation, and three had “Bronze diabetes,” The recommendation on the basis of the results is that well‐designed clinical trials are indicated to monitor asymptomatic brain damage by magnetic resonance imaging in splenectomized patients over the age of 20 years, who are not regularly transfused and have a high risk to develop thromboembolic events. In this subset of patients, anticoagulant and/or antiplatelet therapy should be considered. Moreover, treatment of additional complications resulting from iron overload, which may contribute to the etiology of CVA such as cardiac failure and arrhythmia with or without “bronze diabetes,” is mandatory. Am. J. Hematol. , 2008. © 2007 Wiley‐Liss, Inc.
Association of Number of Children in a Household on the Nutritional Intake of Latino Women

Background: Latinos are the largest minority group in the U.S. Studies have found an inverse relationship between acculturation and many aspects of healthy eating. Furthermore, Latinos have the highest prevalence of being overweight in the U.S. The Latino population in the U.S. presents a major health concern. Public health professional need to identify the major cultural, psychological and environmental factors that propagate the worsening of Latinos diets when they embed themselves into the culture of the U.S. There have been many sociodemographic factors found to be associated with poor dietary intake. However, one area that there is a gap in literature is nutritional intake in regards to number of children in a household. It is important to explore if the factors associated with number of children in a household have an influence on the nutritional intake and psychosocial variables among Latino women in the U.S. Thus, public health professionals can help support families that demonstrate poor diet. Methods: One hundred and seventy nine adult Latino residents of North Carolina completed a questionnaire on their health behaviors, health status, and demographics at a tienda they regularly purchased food. Analyses of the secondary data used 68 Latino women from the original data set. These were households with mothers and their children. Nutritional intake and psychosocial variables of the Latino women were analyzed in regards to number of children in a household. Results: Multiple Linear Regression and Multivariate Logistic Regression analyses were conducted. After adjusting for potential confounding variables of marital status, SES, years in the U.S., and hours worked, results suggest a significant positive association between number of children in a Latino woman's household and her fruit and vegetable intake. Results for fat intake, soda intake, fast food consumption, level of social support for healthy eating she receives, barriers to fruit and vegetable consumption she faces, selfefficacy she has for fruit and vegetable consumption and behavioral strategies for fat she employs were not significantly related to number of children in her household in this present study. Discussion: The positive correlation between family size and fruit and vegetable consumption was a surprising result. A number of possible explanations are provided in the discussion. Follow-up research should examine if the significant association between fruit and vegetable consumption and number of children in a household for Latino women is supported by other studies that have a larger sample size. If this association is confirmed, research should examine why this association holds true.