Miracle-dz/UniFAR-FTUs huggingface dataset:
Perfectionism and the Five-Factor Model of Personality: A Meta-Analytic Review

Over 25 years of research suggests an important link between perfectionism and personality traits included in the five-factor model (FFM). However, inconsistent findings, underpowered studies, and a plethora of perfectionism scales have obscured understanding of how perfectionism fits within the FFM. We addressed these limitations by conducting the first meta-analytic review of the relationships between perfectionism dimensions and FFM traits (k = 77, N = 24,789). Meta-analysis with random effects revealed perfectionistic concerns (socially prescribed perfectionism, concern over mistakes, doubts about actions, and discrepancy) were characterized by neuroticism ( r c + = .50), low agreeableness ( r c + = −.26), and low extraversion ( r c + = −.24); perfectionistic strivings (self-oriented perfectionism, personal standards, and high standards) were characterized by conscientiousness ( r c + = .44). Additionally, several perfectionism–FFM relationships were moderated by gender, age, and the perfectionism subscale used. Findings complement theory suggesting that perfectionism has neurotic and non-neurotic dimensions. Results also underscore that the (mal)adaptiveness of perfectionistic strivings hinges on instrumentation.
Perceived campus safety as a mediator of the link between gender and mental health in a national U.S. college sample

ABSTRACT Men and women tend to have different mental health outcomes. The purpose of this study is to examine the reason for gender differences in college students’ mental health. We examined perceived campus safety as an explanation for the relationship between gender and mental health in college students. According to the social structure and psychological distress paradigm, women are objectively disadvantaged, which creates a sense of powerlessness and causes distress. We hypothesized that perceived campus safety would mediate the relationships between gender and psychological distress as well as gender and sleep disturbances. To test these hypotheses, we examined data from the Spring 2010 American College Health Association National College Health Assessment II (ACHA-NCHA II) survey (N = 95,712) using multilevel structural equation modeling. Results confirmed that perceived campus safety partially mediated the relationship between gender and psychological distress as well as gender and sleep disturbances when controlling for victimization and general health. Women reported that they felt less safe than men on campus and experienced more psychological distress and sleep disturbances. The results of this study suggest that campus administrators could promote student well-being by addressing women’s safety concerns.
Praktyka grozy i praktyki narracyjne. Creepypasta: niesamowitości (w) sieci

PRACTICES OF THE GOTHIC AND NARRATIVE PRACTICE. CREEPYPASTA: THE OTHERWORLDINESS ON THE NET Creepypasta are “true otherworldly stories” spread on the Internet. To be more precise, these stories are characteristic of the contemporary urban folklore. They are referred to as “true stories” or “stories from life”. Their specificity consists in theircirculation (the Internet), their origins and dissemination (copy and paste), the material adapting themes from urban legends and rumors, and the preference for the fantastic and otherworldly. The article contains an analysis of the activity of “pl.creepypasta. wikia.com,”a Polish Internet portal, looking the engagement of its users in the context of the emergence of the institution of the author/editor of texts belonging to Internet folklore.
Modélisation électromagnétique des composants passifs multi-spires multi-couches

Il est classique de constater que la majorite du volume d'un convertisseur d'electronique de puissance est occupee par les composants passifs. Les evolutions actuelles que connait l'electronique de puissance vont donc dans le sens d'une meilleure occupation de l'espace grâce aux techniques de realisation permettant une meilleure integration des composants passifs et une meilleure maitrise de l'environnement. Dans ce cadre, les composants planars presentent un fort avantage concernant les techniques de dimensionnement et d'interconnexion. Ils sont a l'heure actuelle la cle de progres importants realises dans la conception de convertisseur a forte puissance volumique. Pour pousser plus loin ces avantages, un travail important concernant l'optimisation volumique de ces composants a ete engage. Il porte tout d'abord sur la modelisation electromagnetique permettant de modeliser leur comportement electrique. Ce travail devra ensuite etre poursuivi par une modelisation thermique. Cet article porte sur la premiere etape et presente, dans une premiere partie, une methode de modelisation par plaque adaptee aux composants bobines planars. Cette methode sera ensuite etendue pour modeliser les comportements electriques des composants integres presentant des couplages electromagnetiques et electrostatiques. Une modelisation analytique des composants hybrides multi-spires multi-couches LCT constitue la deuxieme partie de cet article. Enfin elle sera confrontee a des mesures realisees sur un LCT en circuit imprime Kapton cuivre 14 couches, 3 spires par couche.
Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence

Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially in the adolescent period when neural maturation may make users particularly vulnerable to the effects of Δ-9-tetrahydrocannabinol (THC) on brain structure. In the current study, we used voxel-based morphometry to compare gray matter volume (GMV) in forty-six 14-year-old human adolescents (males and females) with just one or two instances of cannabis use and carefully matched THC-naive controls. We identified extensive regions in the bilateral medial temporal lobes as well as the bilateral posterior cingulate, lingual gyri, and cerebellum that showed greater GMV in the cannabis users. Analysis of longitudinal data confirmed that GMV differences were unlikely to precede cannabis use. GMV in the temporal regions was associated with contemporaneous performance on the Perceptual Reasoning Index and with future generalized anxiety symptoms in the cannabis users. The distribution of GMV effects mapped onto biomarkers of the endogenous cannabinoid system providing insight into possible mechanisms for these effects. SIGNIFICANCE STATEMENT Almost 35% of American 10th graders have reported using cannabis and existing research suggests that initiation of cannabis use in adolescence is associated with long-term neurocognitive effects. We understand very little about the earliest effects of cannabis use, however, because most research is conducted in adults with a heavy pattern of lifetime use. This study presents evidence suggesting structural brain and cognitive effects of just one or two instances of cannabis use in adolescence. Converging evidence suggests a role for the endocannabinoid system in these effects. This research is particularly timely as the legal status of cannabis is changing in many jurisdictions and the perceived risk by youth associated with smoking cannabis has declined in recent years.
Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair

Background: The impact of gut microbiota on the regulation of host physiology has recently garnered considerable attention, particularly in key areas such as the immune system and metabolism. These areas are also crucial for the pathophysiology of and repair after myocardial infarction (MI). However, the role of the gut microbiota in the context of MI remains to be fully elucidated. Methods: To investigate the effects of gut microbiota on cardiac repair after MI, C57BL/6J mice were treated with antibiotics 7 days before MI to deplete mouse gut microbiota. Flow cytometry was applied to examine the changes in immune cell composition in the heart. 16S rDNA sequencing was conducted as a readout for changes in gut microbial composition. Short-chain fatty acid (SCFA) species altered after antibiotic treatment were identified by high-performance liquid chromatography. Fecal reconstitution, transplantation of monocytes, or dietary SCFA or Lactobacillus probiotic supplementation was conducted to evaluate the cardioprotective effects of microbiota on the mice after MI. Results: Antibiotic-treated mice displayed drastic, dose-dependent mortality after MI. We observed an association between the gut microbiota depletion and significant reductions in the proportion of myeloid cells and SCFAs, more specifically acetate, butyrate, and propionate. Infiltration of CX3CR1+ monocytes to the peri-infarct zone after MI was also reduced, suggesting impairment of repair after MI. Accordingly, the physiological status and survival of mice were significantly improved after fecal reconstitution, transplantation of monocytes, or dietary SCFA supplementation. MI was associated with a reorganization of the gut microbial community such as a reduction in Lactobacillus. Supplementing antibiotic-treated mice with a Lactobacillus probiotic before MI restored myeloid cell proportions, yielded cardioprotective effects, and shifted the balance of SCFAs toward propionate. Conclusions: Gut microbiota–derived SCFAs play an important role in maintaining host immune composition and repair capacity after MI. This suggests that manipulation of these elements may provide opportunities to modulate pathological outcome after MI and indeed human health and disease as a whole.
The prognostic value of mean platelet volume to platelet count ratio in older patients with non-ST elevation acute coronary syndrome receiving primary percutaneous coronary intervention: a retrospective study.

BACKGROUND The aim of this study was to investigate the value of the mean platelet volume to platelet count (MPV/P) ratio for predicting in-hospital and long-term cardiac mortality in older non-ST elevation-acute coronary syndrome (NSTE-ACS) patients after primary percutaneous coronary intervention (PCI). METHODS We retrospectively reviewed 452 older NSTE-ACS patients who received primary PCI. The patients were divided into two groups based on MPV/P ratios: high MPV/P group (N.=150) defined as a value in the third tertile (>0.056628) and low MPV/P group (N.=302) in the lower two tertiles (≤0.056628). Clinical outcomes included non-fatal reinfarction, heart failure, and cardiac mortality. RESULTS Multivariate analyses showed that high MPV/P and MPV values were independent predictors of cardiac mortality. The in-hospital cardiac mortality of the high MPV/P group was higher than the low MPV/P group (1.3% vs. 14.7%, P<0.001). The rates of heart failure and cardiac mortality in one year were significantly higher in the high MPV/P group compared to the low MPV/P group (P<0.05). The cut-off value of MPV/P for predicting cardiac death was 0.067107, with a sensitivity of 0.707 and a specificity of 0.868. MPV/P was superior to MPV (z=9.235, P<0.001) for predicting cardiac mortality. CONCLUSIONS High MPV/P and MPV values are independent predictors of cardiac mortality in older patients with NSTE-ACS receive primary PCI. Moreover, MPV/P is better than MPV for predicting cardiac mortality.
Performance evaluation of disposable inhalable aerosol sampler at a copper electrorefinery

Abstract This study evaluates the performance of the disposable inhalable aerosol sampler (DIAS), a new sampler developed to be more cost-effective than the traditional inhalable particle samplers and comparable to the inhalable particle sampling convention. Forty-eight pairs of the DIAS prototype and the IOM sampler were utilized to collect copper exposure measurements (23 personal and 25 area) at an electrorefinery facility. The geometric mean (GM) value of ratios of exposure data (DIAS/IOM) was 1.1, while the GM of ratios (DIAS/IOM) was 1.6 for the area exposure data, revealing 84% of the ratios were greater than one. For both personal and area exposure data, the concordance correlation coefficient tests revealed significant disagreements between the two types of samplers and suggested precision as the source of the disagreement. The estimated mean concentration was higher for the DIAS compared that for the IOM for the area exposure data (p < 0.05), while the results were comparable for the personal exposure data (p = 0.49). Overall, the DIAS generated higher exposure results compared to the IOM sampler for the area exposures. For the personal exposures, the findings were inconclusive due to inconsistent results of factors aforementioned. This study is limited to one metal component (copper) of the dust at a worksite. To date, this is the first field evaluation using personal exposure data to test the performance of the DIAS and the second evaluation using area exposure data. Thus, it will be necessary to conduct additional field evaluations with various elements to further evaluate the performance of the DIAS. In addition, particle migration to the internal walls of the cap was observed during the transportation of collected samples to a laboratory for both sampler types (6.4% for the DIAS and 7.4% for the IOM). Occupational health and safety professionals should be aware of potential errors caused from transferring samples from a field to a laboratory and should be careful not to exclude particles collected on the caps.
μ‐Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid‐induced hyperalgesia

μ‐Opioid receptors (MORs) are expressed peripherally and centrally, but the loci of MORs responsible for clinically relevant opioid analgesia are uncertain. Crossing Oprm1flox/flox and AdvillinCre/+ mice completely ablates MORs in dorsal root ganglion neurons and reduces the MOR expression level in the spinal cord. Presynaptic MORs expressed at primary afferent central terminals are essential for synaptic inhibition and potentiation of sensory input by opioids. MOR ablation in primary sensory neurons diminishes analgesic effects produced by systemic and intrathecal opioid agonists and abolishes chronic opioid treatment‐induced hyperalgesia. These findings demonstrate a critical role of MORs expressed in primary sensory neurons in opioid analgesia and suggest new strategies to increase the efficacy and reduce adverse effects of opioids.
Prediction of Post Operative Complication in Patients with Valvular Heart Surgery Based on O2 Challenge Test and A-A Gradient

Patients with valvular heart diseases may have more physiological lung derangements and therefore at current study we studied correlation of O2 challenge, A-AG tests and spirometry values of patients who underwent valve surgery on post op respiratory complications. Method: 180 adult patients undergoing non-emergency cardiac valvular surgery were studied. On operating room all patients had arterial blood gas profile (ABG) at room air, 20 minutes after putting on ventilator with 100% O2, and pump oxygenator. Pulmonary function tests, alveolar Oxygen Pressure, mean Arterial pressure of carbon dioxide and alveolar -arterial gradients measured. Results: FEV1, FVC and FEV1/FVC%, pressure of arterial Blood Gasses (O2 and CO2) with fraction of inspired oxygen of 100% and air (PO2-100 and PO2-air), were significantly different between patients with POPC and patients without POPC (p-value <0.05). Indeed PO2-100 and PO2-air were significantly lower in patients with POPC. A-AG100 (p-value: 0.02) and A -AG21 (p-value: 0.02) were significantly higher in patients with POPC in comparison with patients without POPC. The AUC of A-AG100 for predicting POPC was 0.59 (95% confidence interval (CI) 0.51-0.67). The optimal cut point of A-AG100 was 311 and showed evidence of high relatively sensitivity of 80% and a negative predictive value of 61%. Conclusion: Valvular heart surgery still has significant post op complication and mortality. There is significant correlation between A-AG100, A-AG21 percent, PaO2100, and FEV1/FVC with post op complications in these patients. We recommend measurement of these values in pre op evaluation of patient who need cardiac surgery.
LOADng-IoT: An Enhanced Routing Protocol for Internet of Things Applications over Low Power Networks

The Internet of Things (IoT) is an emerging paradigm that proposes the connection of objects to exchange information in order to reach a common objective. In IoT networks, it is expected that the nodes will exchange data between each other and with external Internet services. However, due to deployment costs, not all the network devices are able to communicate with the Internet directly. Thus, other network nodes should use Internet-connected nodes as a gateway to forward messages to Internet services. Considering the fact that main routing protocols for low-power networks are not able to reach suitable performance in the displayed IoT environment, this work presents an enhancement to the Lightweight On-demand Ad hoc Distance-vector Routing Protocol—Next Generation (LOADng) for IoT scenarios. The proposal, named LOADng-IoT, is based on three improvements that will allow the nodes to find Internet-connected nodes autonomously and dynamically, decreasing the control message overhead required for the route construction, and reducing the loss of data messages directed to the Internet. Based on the performed assessment study, which considered several number of nodes in dense, sparse, and mobility scenarios, the proposed approach is able to present significant results in metrics related to quality-of-service, reliability, and energy efficiency.
R-CHOP without radiation in frontline management of primary mediastinal B-cell lymphoma

Abstract Prior to the introduction of rituximab, primary mediastinal B-cell lymphoma (PMBCL) had high rates of treatment failure with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), prompting the use of consolidative mediastinal radiation or more intensive chemotherapy regimens. Cure rates improved dramatically with rituximab, but mediastinal radiation was still commonly employed with R-CHOP. We performed a retrospective review of patients treated with R-CHOP alone without radiation for PMBCL. Of 43 patients with PMBCL, 16 received R-CHOP alone. High-risk factors included 56% with bulky disease, 75% with elevated LDH, 25% with SVC syndrome, and 13% with stage IV disease. Three-year progression-free survival (PFS) and overall survival (OS) were 93% and 100% respectively. These results suggest that R-CHOP alone has a high cure rate in PMBCL while avoiding the side effects of mediastinal radiation.
Dynamic heart rate response to multi‐day unsupported ultra‐endurance cycle racing: a case report

What is the main observation in this case? Ultra‐endurance cycle racing is known to lead to suppressed heart rates as a product of time spent racing. This case report identifies a racer who experienced this phenomenon initially, but then uniquely experienced an overall increase in heart rate late in the race. What insight does it reveal? In this case, unique chronotropic disturbances to heart rate occurred as a result of the many extreme demands of ultra‐endurance racing. Work should now focus on identifying the frequency of this response in other racers and whether the main causes are physiological, environmental or genetic in nature.
Sustainable Porous Carbon Materials Derived from Wood-Based Biopolymers for CO2 Capture

Porous carbon materials with tunable porosities and functionalities represent an important class of CO2 sorbents. The development of porous carbons from various types of biomass is a sustainable, economic and environmentally friendly strategy. Wood is a biodegradable, renewable, sustainable, naturally abundant and carbon-rich raw material. Given these advantages, the use of wood-based resources for the synthesis of functional porous carbons has attracted great interests. In this mini-review, we present the recent developments regarding sustainable porous carbons derived from wood-based biopolymers (cellulose, hemicelluloses and lignin) and their application in CO2 capture.
University of Birmingham Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck

Metastases to the cervical lymph nodes from a occult primary (CUP) of head and neck squamous carcinomas has been increasing in presentation (HNSCC). Modern diagnostic workup, including clinical evaluation, conventional imaging, FDG-PET/CT and panendoscopy/tonsillectomy enables detection of the primary site in over half of all cases, and is associated with significantly improved survival rates. Recent studies have demonstrated the utility of novel molecular pathology and transoral surgical techniques in improving diagnosis and treatment. We present a new, evidence-based protocol incorporating these novel diagnostic modalities. It aims to identify the site of the primary tumor, and determine the stage of the disease, including extranodal extension. This information can personalise treatment recommendations, rationalise combinations of treatment modalities, and thereby potentially minimise toxicity and improving functional outcomes. *Manuscript (without author details) Click here to view linked References
Nanosystèmes électromécaniques pour la biodétection : intégration d'un moyen de transduction et stratégies de biofonctionnalisation

Avec une limite de detection ultime pouvant atteindre le yoctogramme (1 yg = 10-24 g), les nanosystemes electromecaniques (NEMS) employes comme capteurs gravimetriques presentent un fort potentiel pour la detection ultra-sensible et sans marquage de molecules biologiques. A l’heure actuelle, plusieurs defis restent cependant a relever avant de pouvoir envisager de maniere realiste leur utilisation comme outils de biodetection. Ces travaux de these adressent en particulier l’integration du moyen de transduction et le developpement de strategies de biofonctionnalisation. En vue de repondre a la premiere problematique, l’integration d’une couche piezoelectrique a base de Titano-Zirconate de Plomb (PZT) selon une approche de fabrication collective de reseaux de NEMS par voie descendante a ete developpee et caracterisee.Deux approches de biofonctionnalisation adaptees a une organisation de NEMS en reseaux,respectivement basees sur le depot localise de materiel biologique par impression moleculaire et sur la structuration par photolithographie d’une couche bioreceptrice a base de polymeres a empreintes moleculaires (MIP), ont ensuite ete mises en oeuvre et ont permis de demontrer une premiere preuve de concept. Ces differentes contributions constituent un premier pas dans le developpement des NEMS pour des applications de biodetection.