Miracle-dz/UniFAR-FTUs huggingface dataset:
The transfer of best practices: how to build a culture of benchmarking and continuous learning – part 1

Features two case studies. The first of these focuses on Royal Mail, provider of a universal delivery service within the UK. Notes how total quality management has evolved within the organization and how the role of internal good practice has underpinned the development of a continuous improvement environment. Identifies the key enablers for the effective transfer of good practice and the process models adopted. The second case study focuses on Texas Instruments Europe, part of the TI Group and a previous winner of the European Foundation for Quality Management Award. Investigates how different sources provide an extensive database of knowledge for the organization wishing to locate best practices. Identifies the approach adopted to best practice sharing in order to remain focused and achieve maximum benefits within the shortest timeframe. The organization has set up its own office of best practice (OBP) to support the best practice drive and the article focuses on how the OBP expertise is deployed to maximum effect within the organization.
[Indications of laparoscopic general and digestive surgery. Evidence based guidelines of the French society of digestive surgery].

AS. Tous droits réservés. Document téléchargé le 12/12/2019 Il est interdit et illég la littérature. Ces recommandations interviennent dix ans après celles formulées par l’Anaes en 1994 [1]. Une recherche bibliographique a été faite dans trois bases de données (Medline, Embase et Cochrane Library) sur la période de juin 1990 à septembre 2005, en retenant comme langue de publications le français et l’anglais. Nous avons retenu les articles originaux portant sur la laparoscopie en pathologie digestive bénigne et maligne :
Linking E-Government to Good Governance for Sustainable Development in Small Island Developing States

이 논문에서는 도서개발국가들(Small Island Developing States)을 대상으로 전자정부의 발전과 거버넌스와의 관계를 실증적으로 분석하고 있다. 기존 문헌들은 대부분 전자 정부 발전과 거버넌스와의 선형적 관계를 가정하여, 전자정부의 발전이 거버넌스의 다양한 측면에 긍정적 영향을 미치고 있다고 보고하고 있다. 그러나 이 논문에서는 두 변수의.
Electron microscope tomography: further demonstration of nanocontacts between caveolae and smooth muscle sarcoplasmic reticulum

A spatial relationship between caveolae and sarcoplasmic reticulum (SR) in smooth muscle cells (SMC) was previously reported in computer‐assisted three‐dimensional reconstruction from transmission electron microscope serial sections. The knowledge of the three‐dimensional organization of the cortical space of SMC is essential to understand caveolae function at the cellular level. Cellular tomography using transmission electron microscopy tomography (EMT) is the only available technology to reliably chart the inside of a cell and is therefore an essential technology in the study of organellar nanospatial relationships. Using EMT we further demonstrate here that caveolae and peripheral SR in visceral SMC build constantly spatial units, presumably responsible for a vectorial control of free Ca2+ cytoplasmic concentrations in definite nanospaces.
Phenomenology and measurement of circumscribed interests in autism spectrum disorders

Circumscribed interests (CI) are important and understudied symptoms that affect individuals with autism spectrum disorders (ASD). The present study sought to develop quantitative measures of the content, intensity and functional impairment of CI in 50 children with high-functioning ASD compared to an age-, IQ-, and gender-matched sample of 50 typically developing (TD) peers. The Interests Scale, a parent-rating questionnaire, and the Interview for Repetitive Behaviors, a semi-structured interview, were used to assess CI. Groups did not differ on the number of interests children held, but they did differ on types of interests and impairment associated with them. The interests of ASD participants were more likely to be nonsocial in nature (e.g. mechanical systems) than TD participants. Parents of children with ASD endorsed higher degrees of functional impairment on metrics including frequency, interference, resistance when interrupted, flexibility, and accommodation required, as well as less involvement of other people, than parents of children with TD. These findings suggest that interests of individuals with ASD differ qualitatively and in intensity from individuals with TD. The present study offers further support for the notion that CI reflect a clinically significant feature of ASD that warrants intervention in some children.
Targeted : How Technology is Revolutionizing Advertising and the Way Companies Reach Consumers Ed. 1

Far from the catchy television spots and sleek magazine spreads are the comparatively modest ads that pop up on websites and in Internet searches. But don’t be fooled—online advertising is exploding. Growing at a compound annual rate near 20%, it is now the second-largest advertising channel in the United States. Part history, part guidebook, part prediction for the future, Targeted tells the story of the companies, individuals, and innovations driving this revolution. It takes readers behind the scenes—examining the growth of digital advertising, its enormous potential, and the technologies that are changing the game forever. Leading the way is real-time bidding, which offers advertisers unprecedented precision in targeting ads and measuring their effectiveness. From keyword micro-markets and ad serving systems to aggregated virtual audiences and new business models, Targeted is sweeping in scope and stripped of technical complexity. It is an essential resource for anyone interested in finding and connecting with customers in the vast and shifting Internet universe.
An acute bout of exercise modulate the inflammatory response in peripheral blood mononuclear cells in healthy young men

Abstract Context: Exercise increases the levels of circulating inflammatory mediators. Objective: Does an acute bout of exercise affect the mRNA gene expression level of inflammatory markers in peripheral blood mononuclear cells (PBMCs) and contribute to the circulating levels of inflammatory mediators? Materials and methods: Ten healthy, non-smoking men (22–28 years old) performed 1-hour cycling at 70% of VO2 max. Results: The gene transcripts of CXCL16, IL-1β, IL-8, COX-2, TXB21 and GATA3 were significantly up-regulated in PBMCs. Serum levels of CXCL16, IL-6, TNFα and IL-10 were also significantly increased after exercise. Discussion and conclusion: Increased mRNA transcription of inflammatory genes in PBMCs may contribute to increased level of inflammatory markers after an acute bout of exercise. The increased mRNA levels of GATA-3 and TXB21 may indicate that T cell lymphocytes are activated and secrete cytokines into the circulation. It needs to be further investigated if exercise changes the Th1/Th2 balance.
Switching on p53: an essential role for protein phosphorylation?

The p53 tumour suppressor protein coordinates widespread changes in gene expression in response to a range of stress stimuli. p53 is regulated primarily through ubiquitylation and protein turnover mediated by its transcriptional target, MDM2. Induction and activation of p53 is achieved largely through uncoupling the p53/ MDM2 interaction, with various stress stimuli employing different but overlapping mechanisms to achieve this. p53 undergoes a range of post-translational modifications including multi-site phosphorylation, acetylation, methylation and ubiquitylation. DNA damage pathways in particular engender a large number of phosphorylation events, both in p53 itself and in regulatory partners including MDM2 and MDM4; these modifications mediate both the induction of p53 and stimulation of its activity. Surprisingly, other p53-activating stimuli do not promote multi-site phosphorylation. Moreover, simply uncoupling p53 and MDM2 pharmacologically can induce a robust p53 response. Various lines of evidence propose that activation of p53 via the DNA damage pathways is dispensable for p53-mediated tumour suppression and, by implication, that phosphorylation is not required. In contrast to this view, however, emerging evidence from animal models indicates that phosphorylation may indeed impact on tumour suppression, albeit in a possibly selective manner. Here we review the role of phosphorylation in regulating the p53 response in comparison to mechanisms employed by other stress signalling pathways. We consider its effects on biological outcome and reflect on issues that have yet to be addressed.
THE SuperTIGER INSTRUMENT: MEASUREMENT OF ELEMENTAL ABUNDANCES OF ULTRA-HEAVY GALACTIC COSMIC RAYS

The SuperTIGER (Super Trans-Iron Galactic Element Recorder) instrument was developed to measure the abundances of galactic cosmic-ray elements from 10Ne to 40Zr with individual element resolution and the high statistics needed to test models of cosmic-ray origins. SuperTIGER also makes exploratory measurements of the abundances of elements with 40 < Z ⩽ 60 and measures the energy spectra of the more abundant elements for Z ⩽ 30 from about 0.8 to 10 GeV/nucleon. This instrument is an enlarged and higher resolution version of the earlier TIGER instrument. It was designed to provide the largest geometric acceptance possible and to reach as high an altitude as possible, flying on a standard long-duration 1.11 million m3 balloon. SuperTIGER was launched from Williams Field, McMurdo Station, Antarctica, on 2012 December 8, and made about 2.7 revolutions around the South Pole in 55 days of flight, returning data on over 50 × 106 cosmic-ray nuclei with Z ⩾ 10, including ∼1300 with Z > 29 and ∼60 with Z > 49. Here, we describe the instrument, the methods of charge identification employed, the SuperTIGER balloon flight, and the instrument performance.
A Retrospective Survival Analysis of Anatomic and Prognostic Stage Group Based on the American Joint Committee on Cancer 8th Edition Cancer Staging Manual in Luminal B Human Epidermal Growth Factor Receptor 2-negative Breast Cancer

Background: Current understanding of tumor biology suggests that breast cancer is a group of diseases with different intrinsic molecular subtypes. Anatomic staging system alone is insufficient to provide future outcome information. The American Joint Committee on Cancer (AJCC) expert panel updated the 8th edition of the staging manual with prognostic stage groups by incorporating biomarkers into the anatomic stage groups. In this study, we retrospectively analyzed the data from our center in China using the anatomic and prognostic staging system based on the AJCC 8th edition staging manual. Methods: We reviewed the data from January 2008 to December 2014 for cases with Luminal B Human Epidermal Growth Factor Receptor 2 (HER2)-negative breast cancer in our center. All cases were restaged using the AJCC 8th edition anatomic and prognostic staging system. The Kaplan-Meier method and log-rank test were used to compare the survival differences between different subgroups. SPSS software version 19.0 (IBM Corp., Armonk, NY, USA) was used for the statistical analyses. Results: This study consisted of 796 patients with Luminal B HER-negative breast cancer. The 5-year disease-free survival (DFS) of 769 Stage I–III patients was 89.7%, and the 5-year overall survival (OS) of all 796 patients was 91.7%. Both 5-year DFS and 5-year OS were significantly different in the different anatomic and prognostic stage groups. There were 372 cases (46.7%) assigned to a different group. The prognostic Stage II and III patients restaged from anatomic Stage III had significant differences in 5-year DFS (&khgr;2 = 11.319, P = 0.001) and 5-year OS (&khgr;2 = 5.225, P = 0.022). In addition, cases restaged as prognostic Stage I, II, or III from the anatomic Stage II group had statistically significant differences in 5-year DFS (&khgr;2 = 6.510, P = 0.039) but no significant differences in 5-year OS (&khgr;2 = 5.087, P = 0.079). However, the restaged prognostic Stage I and II cases from anatomic Stage I had no statistically significant differences in either 5-year DFS (&khgr;2 = 0.440, P = 0.507) or 5-year OS (&khgr;2 = 1.530, P = 0.216). Conclusions: The prognostic staging system proposed in the AJCC 8th edition refines the anatomic stage group in Luminal B HER2-negative breast cancer and will lead to a more personalized approach to breast cancer treatment.
Single-Dose Pharmacokinetics of Indinavir and the Effect of Food

ABSTRACT Indinavir sulfate is a human immunodeficiency virus type 1 (HIV-1) protease inhibitor indicated for treatment of HIV infection and AIDS in adults. The purpose of this report is to summarize single-dose studies which characterized the pharmacokinetics of the drug and the effect of food in healthy volunteers. Indinavir concentrations in plasma and urine were obtained by high-pressure liquid chromatography and UV detection assay methods. The results indicate that indinavir was rapidly absorbed in the fasting state, with the time to the maximum concentration in plasma occurring at ∼0.8 h for all doses studied. Over the 40- to 1,000-mg dose range studied, concentrations in plasma and urinary excretion of unchanged drug increased greater than dose proportionally. The nonlinear pharmacokinetics were attributed to the dose-dependent oxidative metabolism of first-pass metabolism as well as to metabolism in the systemic circulation. Renal clearance slightly exceeded the glomerular filtration rate, suggesting a net tubular secretion component. At high concentrations in plasma, tubular secretion appeared to be lowered because there was a trend for a decreased renal clearance. Administration of 400 mg of indinavir sulfate following a high-fat breakfast resulted in a blunted and decreased absorption (areas under the concentration-time curves [AUCs], 6.86 μM·h in the fasted state versus 1.54 μM·h in the fed state; n = 10). However, two types of low-fat meals were found to have no significant effect on the absorption of 800 mg of indinavir sulfate (AUCs, 23.15 μM·h in the fasted state versus 22.71 and 21.36 μM·h, respectively, in the fed state; n = 11). Immediately following dosing, the concentrations of indinavir in urine often exceeded its intrinsic solubility. To reduce the risk of nephrolithiasis, it is recommended that indinavir sulfate be administered with water.
A Comparison Between the Seventh and Sixth Editions of the American Joint Committee on Cancer/International Union Against Classification of Gastric Cancer

Objective:To evaluate the prognostic significance of the seventh edition TNM staging classification for gastric cancer. Background:The seventh edition TNM staging system for gastric cancer was adopted by the American Joint Committee on Cancer/International Union Against Cancer on January 1, 2010, and included major revisions. Methods:The authors analyzed data retrospectively collected on patients with gastric cancer who underwent surgery at the Affiliated Hospital of Qingdao University Medical College between 2000 and 2008. A total of 964 patients with gastric cancer who underwent R0 surgical resection were included. Results:The relative risk (RR) for the seventh edition T classification was found to increase steadily and reasonably compared with the sixth edition. However, the RR for the sixth edition N classification was found to increase steadily and reasonably compared with the seventh edition classification. Cox regression multivariate analysis showed that the sixth edition N classification was superior to the seventh edition N classification as an independent prognostic factor. In survival analysis, the seventh edition TNM classification provided a more detailed classification; however, some subgroups of the seventh edition TNM classification did not demonstrate significantly different survival rates. The combination of the seventh edition T classification and the sixth edition N classification, with ideal RR results, showed significantly different survival rates except for IA and IB. Conclusions:The combination of the seventh edition T classification and the sixth edition N classification seems to provide the optimal prognosis.
Accuracy of optimized branched algorithms to assess activity-specific physical activity energy expenditure.

PURPOSE To assess the activity-specific accuracy achievable by branched algorithm (BA) analysis of simulated daily living physical activity energy expenditure (PAEE) within a sedentary population. METHODS Sedentary men (n = 8) and women (n = 8) first performed a treadmill calibration protocol, during which HR, accelerometry (ACC), and PAEE were measured in 1-min epochs. From these data, HR-PAEE and ACC-PAEE regressions were constructed and used in each of six analytic models to predict PAEE from ACC and HR data collected during a subsequent simulated daily living protocol. Criterion PAEE was measured during both protocols via indirect calorimetry. The accuracy achieved by each model was assessed by the root mean square of the difference between model-predicted daily living PAEE and the criterion daily living PAEE (expressed here as percent of mean daily living PAEE). RESULTS Across the range of activities, an unconstrained post hoc-optimized BA best predicted criterion PAEE. Estimates using individual calibration were generally more accurate than those using group calibration (14% vs 16% error, respectively). These analyses also performed well within each of the six daily living activities, but systematic errors appeared for several of those activities, which may be explained by an inability of the algorithm to simultaneously accommodate a heterogeneous range of activities. Analyses between mean square error by subject and activity suggest that optimization involving minimization of root mean square for total daily living PAEE is associated with decreased error between subjects but increased error between activities. CONCLUSIONS The performance of post hoc-optimized BA may be limited by heterogeneity in the daily living activities being performed.
Recommandation argumentée de ressources pédagogiques au sein d'un écosystème apprenant

Un ecosysteme apprenant est un ensemble coherent compose de biocenes de formation favorisant un « apprentissage ensemble » base sur l'echange et le partage de connaissances et/ou de competences pour mieux reussir un projet commun. Les biocenes de formation sont varies et profitent de l'avancee des technologies de l'information et de la communication. Ainsi, la plateforme MEMORAe est un environnement de collaboration organise autour d'un ensemble d'ecosystemes apprenants partageant des ressources pedagogiques issues de biocenes de formation. Bien que partagees, ces ressources peuvent presenter un degre de pertinence plus ou moins fort selon les membres de l'ecosysteme et l'objectif vise. Dans cet article, nous proposons une approche de recommandation argumentee de ressources pedagogiques au sein d'un ecosysteme apprenant. Cette approche est basee sur un systeme de vote permettant a chaque membre de l'ecosysteme de juger la pertinence d'une ou de plusieurs ressources pedagogiques se trouvant a sa disposition dans son ecosysteme apprenant. Mots-cles : Ecosysteme apprenant, systeme de vote, systeme de recommandation, ressource pedagogique.
Facile and scalable synthesis of silicon-based nanocomposites with slitlike nanopores: a solid-state exfoliation reaction using layered CaSi₂.

Silicon-based nanocomposites with slitlike nanopores were prepared by heating a mixture of layered CaSi2 and NiCl2. The formation mechanism is based on a solid-state exfoliation reaction wherein the formation of CaCl2 promotes the extraction of Ca from CaSi2, thereby exfoliating the layered structure. The nanocomposites showed anode capacity for lithium ion batteries up to 804 mA h g(-1).
Correction: Free-Riding Behavior in Vaccination Decisions: An Experimental Study

Citation: The PLOS ONE Staff (2014) Correction: Free-Riding Behavior in Vaccination Decisions: An Experimental Study. PLoS ONE 9(3): e94066. doi:10.1371/journal.pone. 0094066 Published March 27, 2014 Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The essential William James

This title offers an intelligent and insightful exploration of the most notable works of the influential thinker and philosopher, William James. William James (1842-1910) was one of the most original and influential thinkers of the late 19th and early 20th centuries. As a professor at Harvard University he published many works that had a wide-ranging impact on both psychology and philosophy. His "Principles of Psychology" was the most important English-language work on the mind since Locke's Essay Concerning Human Understanding. This intelligent volume covers the primary topics for which James is still closely studied - the nature of experience, the functions of the mind, the criteria for knowledge, the definition of 'truth,' and ethical and religious philosophy - providing readers with a fascinating tour of James' most noteworthy achievements.
Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis.

OBJECTIVE In approximately 25% of synovial tissues from rheumatoid arthritis (RA) patients, infiltrates of T cells, B cells, and follicular dendritic cells (FDCs) are spatially organized into structures resembling lymph nodes with germinal centers. The remainder of the tissues lack FDCs and show either a diffuse or an aggregated T cell and B cell infiltrate. To gain more insight into this specific disease process, we sought to identify the genes expressed in RA tissues with ectopic lymphoid structures. METHODS Gene expression profiling of RA synovial tissues was determined by complementary DNA microarray analysis and quantitative real-time polymerase chain reaction. The presence of lymphoid follicles and localization of interleukin-7 (IL-7) in synovial tissue sections was determined by immunofluorescence staining using specific antibodies. RESULTS Findings of gene expression analysis confirmed previous reports that tissues with lymphoid structures showed elevated expression of CXCL13, CCL21, CCR7, and lymphotoxin alpha and beta messenger RNA. In addition, the tissues also showed enhanced expression of the chemokines CXCL12 and CCL19 and the associated receptors CXCR4 and CXCR5, which are important for the attraction of T cells, B cells, and dendritic cells. Pathway analysis revealed increased expression of genes involved in JAK/STAT signaling, T cell- and B cell-specific pathways, Fcepsilon receptor type I signaling in mast cells, and IL-7 signal transduction in the tissues with ectopic lymphoid follicles, accompanied by increased expression of IL-7 receptor alpha (IL-7Ralpha)/IL-2Rgamma chains and IL-7. Protein expression of IL-7 in RA tissues was localized within fibroblast-like synoviocytes, macrophages, and blood vessels and was colocalized with extracellular matrix structures around the B cell follicles. CONCLUSION Activation of the IL-7 pathway may play an important role in lymphoid neogenesis, analogous to its role in the development of normal lymphoid tissue.