Miracle-dz/UniFAR-FTUs huggingface dataset:
EC-Store: Bridging the Gap between Storage and Latency in Distributed Erasure Coded Systems

Cloud storage systems typically choose between replicating or erasure encoding data to provide fault tolerance. Replication ensures that data can be accessed from a single site but incurs a much higher storage overhead, which is a costly downside for large-scale storage systems. Erasure coding has a lower storage requirement but relies on encoding/decoding and distributed data retrieval, which can result in straggling requests that increase response times. We propose strategies for data access and data movement within erasure-coded storage systems that significantly reduce data retrieval times. We present EC-Store, a system that incorporates these dynamic strategies for data access and movement based on workload access patterns. Through detailed evaluation using two benchmark workloads, we show that EC-Store incurs significantly less storage overhead than replication while achieving better performance than both replicated and erasure-coded storage systems.
SYSTEM IDENTIFICATION AND DEREVERBERATION OF SPEECH SIGNALS IN THE SINGLE-SIDEBAND TRANSFORM DOMAIN

Single-Side-Band transform (SSB) is an important realvalued time-frequency representation, often preferred in applications involving speech signals. In this paper, the problems of system identification and dereverberation are addressed using the SSB transform. First, an analytical relation between the input and the output signals is derived in the SSB domain. Then, a system identification routine is formulated for a band-to-band approximation of that relation. Second, the dereverberation problem is addressed, using a statistical model for the acoustic impulse response (AIR) function. Exact and approximate representations of the AIR and the reverberant signal are derived directly in the SSB domain. The performance of the dereverberation algorithm is evaluated as a function of the representation complexity. Finally, the SSB and the short-time Fourier transform (STFT) representations are compared for the application of dereverberation.
On the Observed Relationships between Wintertime Variability in Kuroshio–Oyashio Extension Sea Surface Temperatures and the Atmospheric Circulation over the North Pacific

Observational analyses reveal that wintertime variations in sea surface temperatures (SST) in the Kuroshio–Oyashio Extension (KOE) region of the North Pacific are associated with two distinct and robust patterns of atmospheric variability: 1) a pattern that peaks in amplitude approximately 2–3 weeks prior to large KOE SST anomalies and is consistent with atmospheric forcing of the SST field and 2) a very different pattern that lags SST anomalies in the KOE region by approximately a month. The latter pattern is dominated by low sea level pressure anomalies and turbulent heat fluxes directed into the atmosphere over warm SST anomalies and is interpreted as the transient atmospheric response to SST anomalies over the KOE region. The results contribute to a growing body of evidence that suggests variations in SSTs in the midlatitude oceans are capable of significantly influencing the large-scale atmospheric circulation, especially near western boundary currents.
A Corpus with Multi-Level Annotations of Patients, Interventions and Outcomes to Support Language Processing for Medical Literature

We present a corpus of 5,000 richly annotated abstracts of medical articles describing clinical randomized controlled trials. Annotations include demarcations of text spans that describe the Patient population enrolled, the Interventions studied and to what they were Compared, and the Outcomes measured (the ‘PICO’ elements). These spans are further annotated at a more granular level, e.g., individual interventions within them are marked and mapped onto a structured medical vocabulary. We acquired annotations from a diverse set of workers with varying levels of expertise and cost. We describe our data collection process and the corpus itself in detail. We then outline a set of challenging NLP tasks that would aid searching of the medical literature and the practice of evidence-based medicine.
Design principles of a microtubule polymerase

Stu2/XMAP215 microtubule polymerases use multiple tubulin-binding TOG domains and a lattice-binding basic region to processively promote faster elongation. How the domain composition and organization of these proteins dictate polymerase activity, end localization, and processivity is unknown. We show that polymerase activity does not require different kinds of TOGs, nor are there strict requirements for how the TOGs are linked. We identify an unexpected antagonism between the tubulin-binding TOGs and the lattice-binding basic region: lattice binding by the basic region is weak when at least two TOGs engage tubulins, strong when TOGs are empty. End-localization of Stu2 requires unpolymerized tubulin, at least two TOGs, and polymerase competence. We propose a ‘ratcheting’ model for processivity: transfer of tubulin from TOGs to the lattice activates the basic region, retaining the polymerase at the end for subsequent rounds of tubulin binding and incorporation. These results clarify design principles of the polymerase.
Succession of embryonic and the intestinal bacterial communities of Atlantic salmon (Salmo salar) reveals stage‐specific microbial signatures

Host‐associated microbiota undergoes a continuous transition, from the birth to adulthood of the host. These developmental stage‐related transitions could lead to specific microbial signatures that could impact the host biological processes. In this study, the succession of early‐life and intestinal bacterial communities of Atlantic salmon (starting from embryonic stages to 80‐week post hatch; wph) was studied using amplicon sequencing of 16S rRNA. Stage‐specific bacterial community compositions and the progressive transitions of the communities were evident in both the early life and the intestine. The embryonic communities showed lower richness and diversity (Shannon and PD whole tree) compared to the hatchlings. A marked transition of the intestinal communities also occurred during the development; Proteobacteria were dominant in the early stages (both embryonic and intestinal), though the abundant genera under this phylum were stage‐specific. Firmicutes were the most abundant group in the intestine of late freshwater; Weissella being the dominant genus at 20 wph and Anaerofilum at 62 wph. Proteobacteria regained its dominance after the fish entered seawater. Furthermore, LEfSe analysis identified genera under the above ‐ mentioned phyla that are significant features of specific stages. The environmental (water) bacterial community was significantly different from that of the fish, indicating that the host is a determinant of microbial assemblage. Overall the study demonstrated the community dynamics during the development of Atlantic salmon.
Retinal Vascular Segmentation using Random Forest

Accurate extraction of retinal blood vessels from the fundus has recently become a vital task in computer aided diagnosis of retinopathy. In this work, we describe an automated method based on simple edge detection features and random forest to locate the blood vasculature in images. The method was evaluated on the publicly-available DRIVE database which has been established to enable comparative studies on segmentation of blood vessels in retinal images [1]. The proposed method achieved 93.96% accuracy, which despite its simplicity, can be considered as a comparable result to that reported by the most accurate methods in literature.
Accommodation, Convergence, and Stereopsis in Dyslexic Schoolchildren

BACKGROUND: Previous studies have shown a correlation between reading problems and binocular function, but few studies have assessed visual skills in dyslexic students, particularly in Iranian Farsi-language students. This study is aimed to determine some of the binocular functions of dyslexic children and compare it with a group of age, sex, and social class-matched control children. MATERIALS AND METHODS: We conducted a case–control study on 27 dyslexic children and 40 age, sex, and social class-matched control children (all between 7 and 13 years old) in grades one to six. This study was performed at three elementary schools in Tehran, Iran. Monocular and binocular near point of accommodation (NPA) were measured using the subjective push-up method, near point of convergence (NPC) was determined using the standard push-up technique, and stereoacuity was tested with the Titmus stereotypes in all of the children. RESULTS: Mean NPA of the right eye was 6.90 cm in dyslexic group and 5.98 cm in the control group (P = 0. 003). Mean NPA of the left eye in dyslexic children was 7.32 cm and in the control group was 6.23 cm (P = 0. 003). Mean binocular NPA was 6.66 cm in dyslexic and 6 cm in the control group (P = 0. 049). However, mean NPC (P = 0.33) and mean stereoacuity (P = 0.785) did not differ significantly between the dyslexic and control groups. CONCLUSION: Our findings showed a reduced monocular and binocular NPA in dyslexic children so that this function should be assessed by an optometric clinician in children with dyslexia.
Dissipative solitons with extreme spikes in the normal and anomalous dispersion regimes

Prigogine’s ideas of systems far from equilibrium and self-organization (Prigogine & Lefever. 1968 J. Chem. Phys. 48, 1695–1700 (doi:10.1063/1.1668896); Glansdorff & Prigogine. 1971 Thermodynamic theory of structures, stability and fluctuations. New York, NY/London, UK: Wiley) deeply influenced physics, and soliton science in particular. These ideas allowed the notion of solitons to be extended from purely integrable cases to the concept of dissipative solitons. The latter are qualitatively different from the solitons in integrable and Hamiltonian systems. The variety in their forms is huge. In this paper, one recent example is considered—dissipative solitons with extreme spikes (DSESs). It was found that DSESs exist in large regions of the parameter space of the complex cubic–quintic Ginzburg–Landau equation. A continuous variation in any of its parameters results in a rich structure of bifurcations. This article is part of the theme issue ‘Dissipative structures in matter out of equilibrium: from chemistry, photonics and biology (part 1)’.
Antibiotic Resistance Characterization of Environmental E. coli Isolated from River Mula-Mutha, Pune District, India

In the current study, ceftazidime- and ciprofloxacin-resistant—or dual drug-resistant (DDR)—E. coli were isolated from river Mula-Mutha, which flows through rural Pune district and Pune city. The DDR E. coli were further examined for antibiotic resistance to six additional antibiotics. The study also included detection of genes responsible for ceftazidime and ciprofloxacin resistance and vectors for horizontal gene transfer. Twenty-eight percent of the identified DDR E. coli were resistant to more than six antibiotics, with 12% being resistant to all eight antibiotics tested. Quinolone resistance was determined through the detection of qnrA, qnrB, qnrS and oqxA genes, whereas cephalosporin resistance was confirmed through detection of TEM, CTX-M-15, CTX-M-27 and SHV genes. Out of 219 DDR E. coli, 8.2% were qnrS positive and 0.4% were qnrB positive. Percentage of isolates positive for the TEM, CTX-M-15 and CTX-M-27 genes were 32%, 46% and 0.9%, respectively. None of the DDR E. coli tested carried the qnrA, SHV and oqxA genes. Percentage of DDR E. coli carrying Class 1 and 2 integrons (mobile genetic elements) were 47% and 8%, respectively. The results showed that antibiotic resistance genes (ARGs) and integrons were present in the E. coli isolated from the river at points adjoining and downstream of Pune city.
Estimating an Individual’s Probability of Revision Surgery After Knee Replacement: A Comparison of Modeling Approaches Using a National Data Set

Abstract Tools that provide personalized risk prediction of outcomes after surgical procedures help patients make preference-based decisions among the available treatment options. However, it is unclear which modeling approach provides the most accurate risk estimation. We constructed and compared several parametric and nonparametric models for predicting prosthesis survivorship after knee replacement surgery for osteoarthritis. We used 430,455 patient-procedure episodes between April 2003 and September 2015 from the National Joint Registry for England, Wales, Northern Ireland, and the Isle of Man. The flexible parametric survival and random survival forest models most accurately captured the observed probability of remaining event-free. The concordance index for the flexible parametric model was the highest (0.705, 95% confidence interval (CI): 0.702, 0.707) for total knee replacement and was 0.639 (95% CI: 0.634, 0.643) for unicondylar knee replacement and 0.589 (95% CI: 0.586, 0.592) for patellofemoral replacement. The observed-to-predicted ratios for both the flexible parametric and the random survival forest approaches indicated that models tended to underestimate the risks for most risk groups. Our results show that the flexible parametric model has a better overall performance compared with other tested parametric methods and has better discrimination compared with the random survival forest approach.
Automatic segmentation of pupil using local histogram and standard deviation

This paper presents a novel approach for automatic pupil segmentation. The proposed algorithm uses local histogram and standard deviation based adaptive thresholding method that looks for the region that has the highest probability of having the pupil. We have tested our proposed algorithm on two public databases namely: CASIA v1.0 and MMU v1.0. Experimental results show that the proposed method has satisfying performance and good robustness against the reflection in the pupil.
Maternal Serum and Breast Milk Adiponectin: The Association with Infant Adiposity Development

The prevalence of childhood obesity is increasing at an alarming rate in Malaysia. Metabolic changes during pregnancy are critical to the development of infant adiposity, due to imbalanced adipokines production. Hence, we aimed to investigate the association of maternal serum and breast milk adipokines with infant adiposity development. The study was conducted from April 2010 until December 2012. A total of 155 healthy pregnant mothers aged 19 to 40 years were recruited during the first and second trimester in Kelantan, Malaysia. Data consisted of maternal sociodemographic details, anthropometry and clinical biochemistry analysis; and the infant’s anthropometry and feeding patterns. Maternal fasting serum and breast milk samples were analysed for adiponectin and leptin levels. Data collection was performed in the second and third trimester of pregnancy, and continued with follow-up visits at birth, two, six, and 12 months postpartum. Multiple linear regression (MLR) analyses were performed to examine the associations between maternal serum and breast milk adiponectin and leptin and infant adiposity development. MLR models showed that, in the first year, as maternal serum and breast milk adiponectin increased, infant weight, BMI-for-age Z scores and abdominal circumference significantly decreased (p < 0.05). Maternal serum and/or breast milk adiponectin was associated with first-year infant adiposity development.
Endoplasmic reticulum stress is involved in the T‐2 toxin‐induced apoptosis in goat endometrium epithelial cells

T‐2 toxin is one of the trichothecene mycotoxins commonly found in animal feed and agricultural products. Ingestion of T‐2 toxin by animals results in acute and chronic diseases, as well as reproductive failure. This study aimed at investigating the role of endoplasmic reticulum (ER) stress in T‐2 toxin‐induced apoptosis in goat endometrium epithelial cells. Flow cytometry and cell viability assay showed that T‐2 toxin significantly induced cell apoptosis, which was accompanied with increased expression of cleaved‐caspase‐3. The altered expression of two ER stress markers CHOP and GRP78 proved that ER stress is involved in the T‐2 toxin‐induced apoptosis. 4‐phenylbutyrate pretreatment was applied to relieve the ER stress, pretreated endometrium epithelial cells showed a decreased apoptosis level and the expression pattern of CHOP and GRP78 was reversed. The key genes involved in signaling pathways of ER stress‐associated apoptosis were examined, which showed that the IRE1‐JNK and PERK‐ATF4‐CHOP signal transduction pathways are both activated. Moreover, the level of cytokines including interleukin (IL)‐1β, IL‐6, IL‐10 and tumor necrosis factor‐α decreased in the T‐2 toxin‐treated cells. While the 4‐phenylbutyrate pretreatment elevates the cytokine levels after T‐2 treatment. Collectively, these results suggest that ER stress contributes to the T‐2 toxin‐induced apoptosis and decreased cytokine levels in goat endometrium epithelial cells. This study offers new insight into the molecular mechanisms of T‐2 toxicity on reproductive cells.
Adverse Childhood Experiences and Hospital-Treated Self-Harm

Adverse childhood experiences (ACEs) have been implicated in a range of negative health outcomes in adulthood, including increased suicide mortality. In this study, we explored the relationship between ACEs and hospital-treated self-harm. Specifically, we investigated whether those who had a history of repeat self-harm reported more ACEs than those who had self-harmed for the first time. Patients (n = 189) admitted to two hospitals in Glasgow (UK) following first-time (n = 41) or repeated (n = 148) self-harm completed psychosocial measures. Univariate analyses revealed that those presenting with repeat self-harm reported higher depressive symptoms, anxiety symptoms, intent to die, and ACEs, and lower dependent attachment style. However, only ACEs, along with female gender and depressive symptoms, significantly differentiated between the repeat self-harm group and the first-time self-harm group in the multivariate model. Controlling for all other psychosocial variables, participants who reported 4+ ACEs were significantly more likely to be in the repeat self-harm group as compared to those who experienced 0–3 ACEs. This finding highlights the pernicious effect of exposure to multiple ACEs. Further research is urgently required to better understand the mechanisms that explain this relationship. Clinicians should be aware of the extent of the association between ACEs and repeat self-harm.
A dysprosium quantum gas in highly controllable optical traps

In this thesis we present Bose-Einstein condensation of a gas of dysprosium atoms. Our cooling procedure relies on a Zeeman slower and a narrow-line magneto-optical trap. For better optical access we load the atoms directly in an optical dipole trap and transport them to a glass cell, where the atoms are loaded into a crossed optical trap. There we employ forced evaporative cooling towards condensation. We measure the linewidth of the broad 421 nm transition to be Γ421/2π = (33± 1) MHz. By measurements of the trap frequencies in the optical traps we derive the dynamic polarizability to (102±20) a.u. at λ = 1070 nm and (82±13) a.u. at 1064 nm. Additionally, we give an estimate of 10.5 a.u. at 532 nm. We further employ a micrometer-resolution imaging system for in-trap imaging of the quantum gas. There we use phase-contrast imaging to nondestructively probe the latter. With the elctro-optical deflector system set up during this thesis the imaging system can be used to imprint tailored optical potentials.
Will Becoming More Creative Make us More Tolerant?

Abstract This commentary attempts to address the question of “Why creativity matters? ” from the perspective of social psychology, by pointing out processes, which promote creativity while diminishing prejudices. I argue that through enhancing creativity, stereotyping can be reduced which can translate to the further improvement of intergroup relations. The common correlates of low prejudices and creativity supporting this hypothesis, are presented in this paper and comprise: (1) cognitive flexibility, (2) openness to experience and (3) perspective taking. Further, I invoke the existing literature regarding the link between schema-inconsistencies and creativity, which highlights the interrelatedness of these processes, but views creativity as an outcome, rather than a tool for social change. The assumed relationship can be seen as an opening to numerous future research paths, as it can give rise to various detailed questions from the points of view of basic and applied psychology.
Let’s do it “again”: A First Computational Approach to Detecting Adverbial Presupposition Triggers

We introduce the novel task of predicting adverbial presupposition triggers, which is useful for natural language generation tasks such as summarization and dialogue systems. We introduce two new corpora, derived from the Penn Treebank and the Annotated English Gigaword dataset and investigate the use of a novel attention mechanism tailored to this task. Our attention mechanism augments a baseline recurrent neural network without the need for additional trainable parameters, minimizing the added computational cost of our mechanism. We demonstrate that this model statistically outperforms our baselines.
Advance care planning for frail older people in China: A discussion paper

As the aging population, including frail older people, continues to grow in Mainland China, quality of life and end-of-life care for frail older people has attracted much attention. Advance care planning is an effective way to improve end-of-life care for people with advanced diseases, and it is widely used in developed countries; however, it is a new concept in Mainland China. The effects of advance care planning and its acceptability in Mainland China are uncertain because of its culture-sensitive characteristics. The objective of this article is to discuss the serious social issue of caring for frail older people and illustrate the possibility of implementing advance care planning in nursing homes in Mainland China through a review of relevant literature, which will focus on legislation, healthcare system engagement, public engagement, and cultural issues. Recommendations to promote and implement advance care planning include choosing nursing homes as a proper setting, establishing an ethical climate, and enhancing public awareness.
Tumor necrosis factor superfamily 15 promotes lymphatic metastasis via upregulation of vascular endothelial growth factor‐C in a mouse model of lung cancer

Lymphatic metastasis is facilitated by lymphangiogenic growth factor vascular endothelial growth factor‐C (VEGFC) that is secreted by some primary tumors. We previously identified tumor necrosis factor superfamily 15 (TNFSF15), a blood vascular endothelium‐derived cytokine, in lymphatic endothelial cells, as a key molecular modulator during lymphangiogenesis. However, the effect of TNFSF15 on tumor lymphatic metastasis and the underlying molecular mechanisms remain unclear. We report here that TNFSF15, which is known to inhibit primary tumor growth by suppressing angiogenesis, can promote lymphatic metastasis through facilitating lymphangiogenesis in tumors. Mice bearing tumors induced by A549 cells stably overexpressing TNFSF15 exhibited a significant increase in densities of lymphatic vessels and a marked enhancement of A549 tumor cells in newly formed lymphatic vessels in the primary tumors as well as in lymph nodes. Treatment of A549 cells with TNFSF15 results in upregulation of VEGFC expression, which can be inhibited by siRNA gene silencing of death domain‐containing receptor‐3 (DR3), a cell surface receptor for TNFSF15. In addition, TNFSF15/DR3 signaling pathways in A549 cells include activation of NF‐κB during tumor lymphangiogenesis. Our data indicate that TNFSF15, a cytokine mainly produced by blood endothelial cells, facilitates tumor lymphangiogenesis by upregulating VEGFC expression in A549 cells, contributing to lymphatic metastasis in tumor‐bearing mice. This finding also suggests that TNFSF15 may have potential as an indicator for prognosis evaluation.