Miracle-dz/UniFAR-FTUs huggingface dataset:
Aldosterone-mediated regulation of ENaC α, β, and γ subunit proteins in rat kidney

Aldosterone stimulates sodium transport in the renal collecting duct by activating the epithelial sodium channel (ENaC). To investigate the basis of this effect, we have developed a novel set of rabbit polyclonal antibodies to the 3 subunits of ENaC and have determined the abundance and distribution of ENaC subunits in the principal cells of the rat renal collecting duct. Elevated circulating aldosterone (due to either dietary NaCl restriction or aldosterone infusion) markedly increased the abundance of alphaENaC protein without increasing the abundance of the beta and gamma subunits. Thus, alphaENaC is selectively induced by aldosterone. In addition, immunofluorescence immunolocalization showed a striking redistribution in ENaC labeling to the apical region of the collecting duct principal cells. Finally, aldosterone induced a shift in molecular weight of gammaENaC from 85 kDa to 70 kDa, consistent with physiological proteolytic clipping of the extracellular loop as postulated previously. Thus, at the protein level, the response of ENaC to aldosterone stimulation is heterogenous, with both quantitative and qualitative changes that can explain observed increases in ENaC-mediated sodium transport.
A Preliminary Experimental Examination of the Effect of Emotion Dysregulation and Impulsivity on Risky Behaviors Among Women With Sexual Assault–Related Posttraumatic Stress Disorder

Posttraumatic stress disorder (PTSD) is associated with a wide range of risky behaviors (e.g., substance use and risky sexual behaviors); however, few studies have examined mechanisms that may underlie risky behaviors in this population. The present study utilized a prospective experimental design to examine the effects of emotion dysregulation and impulsivity on risky behaviors across time. Thirty women with sexual assault–related PTSD were randomly assigned to receive emotion modulation (EM), impulsivity reduction (IR), or healthy living (HL; comparison condition) skills trainings. Participants completed measures of emotion dysregulation, impulsivity, and risky behaviors pre-manipulation and 1-month post-manipulation. Participants in the EM and IR conditions reported a significant reduction in risky behaviors from pre- to post-manipulation relative to the HL condition. Changes in emotion dysregulation from pre- to post-manipulation fully accounted for reductions in risky behaviors over time. Results provide preliminary experimental support for the role of emotion dysregulation in risky behaviors.
Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels

Apolipoprotein E (apoE) is one of the major protein constituents of chylomicron and very‐low‐density lipoprotein (VLDL) remnants and plays a central role as a ligand in the receptor‐mediated uptake of these particles by the liver. Including the most common variant, apoE3, 30 apoE variants have been characterized. At present, 14 apoE variants have been found to be associated with famiiial dysbetalipoproteinemia, a genetic lipid disorder characterized by elevated plasma cholesterol and triglyceride levels and an increased risk for atherosclerosis. Seven apoE variants were found to be associated with other forms of hyperlipoproteinemia. This report presents an overview of all currently known apoE variants and their effects on lipoprotein metabolism. © 1994 Wiley‐Liss, Inc.
Benefits of thin‐shelled acetabular components for metal‐on‐metal hip resurfacing arthroplasty

The theoretical advantage of using thinner acetabular components in hip resurfacing has not yet been clinically verified. Our purpose was to test the hypothesis of bone conservation and assess the effects of using a thinner acetabular component on hip biomechanics and clinical outcome. We compared the bone conservation, biomechanical results, and functional outcomes between hips in 35 patients who received bilateral metal‐on‐metal resurfacing arthroplasties with acetabular components of 5 mm thickness on one side and 3.5 mm thickness on the other. Acetabular abduction angle and acetabular anteversion were measured using Ein‐Bild‐Röentgen‐Analysis software. Medial acetabular wall thickness and position of the hip center of rotation were measured using Image J software. The change in position of the hip center of rotation was minimal and did not reach significance. Thin‐shelled components showed greater bone conservation on the acetabular side measured by an increase in the medial acetabular wall thickness. Bone conservation on the femoral side was achieved as well with thin shells. Range of motion, pain scores, and complication rates were comparable. No appreciable difference was found in bone‐cup radiographic appearance between the two types of components. These data suggest that patients can experience good clinical outcomes for resurfacing with either thin or thick‐shelled acetabular components. However, thin‐shelled components preserve acetabular bone stock and allow the use of a larger femoral component. The use of thinner acetabular components is an improvement in bone conservation for a hip resurfacing design. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1665–1670, 2010
Comparison ASL and DCE-MRI Perfusion Map in Small Animal Model of Cancer

This paper is focused on quantitative perfusion analysis using pulsed ASL (FAIRRARE) and DCE-MRI (using high- and low-molecular-weight contrast agents) in a mouse tumour model. Tumour blood-flow maps of both methods were compared using visual assessment, region analysis (median, percentiles), scatter plots and correlation coefficients. ASL blood-flow estimates matched the DCE-MRI blood-flow estimations in some cases. Possible reasons for poor match in the other cases were investigated. This study indicates that in tumour perfusion analysis, we might profit from the combination of ASL and DCEMRI instead of using just one of them.
Data warehouses in MongoDB vs SQL Server: A comparative analysis of the querie performance

Due to its historical nature, data warehouses require that large volumes of data need to be stored in their repositories. Some organizations are beginning to have problems to manage and analyze these huge volumes of data. This is due, in large part, to the relational databases which are the primary method of data storage in a data warehouse, and start underperforming, crumbling under the weight of the data stored. In opposition to these systems, arise the NoSQL databases that are associated with the storage of very large volumes of data inherent to the Big Data paradigm. Thus, this article focuses on the study of the feasibility and the implications of the adoption of a NoSQL database, within the data warehousing context. MongoDB was selected to represent the NoSQL systems in this investigation. In this paper will be explained the processes required to design the structure of a data warehouse and typically dimensional queries in the MongoDB system. The undertaken research culminates in the performance analysis of queries executed in a traditional data warehouse, based on the SQL Server system, and an equivalent data warehouse based on the MongoDB system.
DEPTH FROM RELATIVE NORMAL FLOW FIELDS

Abstrlet--Most of the depth from image flow algorithms has to rely on either good initial guesses, or some assumptions about the object surfaces to achieve solutions that agree with the physical world. Waxman and Sinha point out that those restrictions can be relaxed if depth is computed from a relative image flow field. Since image flow determination is relatively much more difficult than normal flow determination, it is of interest to develop an algorithm to recover depth from normal flows. In this paper, we have shown that similar results can be obtained from relative normal flow fields as from relative image flow fields. We have implemented a normal flow estimation algorithm, and applied our algorithm to recover depth from intensity images.
[Microarray analysis of differentially expressed genes in peripheral leucocytes derived from severe preeclampsia and normotensive pregnancies].

OBJECTIVE To investigate genes involved in the mechanisms underlying the progression of severe preeclampsia. METHODS We conducted a multiregional gene expression analysis using peripheral leucocytes from patients with preeclampsia and normal controls. Total RNA was extracted from peripheral blood of six severe preeclampsia and five normotensive pregnancies. We performed genome-wide expression profiling using Affymetrix HG_U133 plus 2.0 chips to screen out differentially expressed genes of 2 fold or more and q_value < 5.4%. Using Gene Ontology we identified the function of differentially expressed genes after cluster analysis. RESULTS Among the 47 000 genes that were screened in the microarray, 140 genes were found to be differentially expressed between normal and preeclamptic pregnancies. Eighty six up-regulated candidate genes were mainly involved in cysteine metabolism urea cycle and metabolism of amiogroups, proteasome, TGF-beta signaling pathway, and the ratio of calponin2 (CNN2), matrix metallopeptidase 8 (MMP8), V-set and immunoglobulin domain containing 4 (VSIG4), proteasome 26S subunit ATPase 5 (PSMC5) was evidently increased in preeclampsia patients. Among 54 down-regulated candidates, natural killer cell mediated cytotoxicity, antigen processing and presentation, metabolism of xenobiotics by cytochrome P450 were the main pathways. KIR3DL2, AKR1C3, CHURC1 and SLC25A13 were obviously decreased in preeclampsia patients. CONCLUSIONS The gene expression of peripheral leucocytes in preeclampsia patients is significantly different from that of uncomplicated pregnancies. CNN2, MMP8, VSIG4, PSMC5, KIR3DL2, AKR1C3, CHURC1 and SLC25A13 may be involved in the molecular mechanisms underlying the progression of severe preeclampsia.
Topology optimization of monostatic radar networks with wide-beam antennas

In this paper, the algorithm for topology optimization of monostatic radar networks is presented. Possibility to include antenna pattern of each particular radar makes this algorithm novel. In this algorithm, the Fisher information matrix is used as the figure of merit of the target localization accuracy. Antenna pattern of each single radar is included through exploitation of the dependence of the variance of the target range estimation upon its elevation and azimuth. Numerical results show that areas of the target's high localization accuracy are mainly determined by the radars' antenna patterns, which proves importance of antenna patterns consideration by optimizing radar network topology.
OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR SUCCESSIVE INDEPENDENCE AND BEHAVIORAL CONTRAST IN A CLOSED ECONOMY

Two pigeons had access to multiple concurrent schedules of reinforcement for 24 hours per day in their home cages. The variable-interval schedules comprising the multiple concurrent schedules were varied across 16 conditions. In three sets of conditions, one schedule was varied while its concurrent alternative and the concurrent schedules in the other component were held constant. Behavioral contrast was observed; that is, as the rate of reinforcement arranged by the varied schedule decreased, response rates on the constant schedules typically increased. These conditions formed part of two larger sets of conditions in which the concurrent schedules in one multiple-schedule component remained constant while the concurrent schedules in the other component were varied. Successive independence was found, in that behavior allocation during the constant component did not vary as a function of the reinforcer ratios in the varied component. Successive independence between components in multiple concurrent schedules is a robust result that occurs in closed economies and under conditions that promote behavioral contrast.
Vein grafts to augment flexor tendon repairs: a biomechanical study on strength and gap resistance

The ultimate tensile repair strength and gap formation of the pig extensor tendons repaired with a standard 4-strand Savage with epitendinous suture repair, was compared with a new technique of adding a vein sleeve. Force and displacement data were recorded, and video images during linear cyclic loading up to failure. At 35 N, video-graphic observation detected significantly smaller gap lengths in the standard and vein repair specimens compared with standard repair specimens (p = 0.047). The incidence of 3 mm gaps between the repaired tendon ends in the standard repair group was 20 %, but no 3 mm gaps were seen in the standard and vein specimens. The addition of a vein sleeve increased the ultimate tensile strength of the standard repair from 50.4 N (4.5) to 55.4 N (4.5); this was statistically significant (p = 0.03). This study demonstrated that the addition of a vein graft prevented gap formation and increased ultimate tensile strength of tendon repair.
Imatinib mesylate (STI571) treatment in patients with chronic‐phase chronic myelogenous leukaemia previously submitted to autologous stem cell transplantation

Summary. Imatinib mesylate (STI571) is a highly effective and well‐tolerated treatment for patients with chronic‐phase chronic myeloid leukaemia (CML), but information on its efficacy and tolerance in intensively pretreated patients is scarce. Thirty‐three chronic‐phase CML patients who were resistant or intolerant to interferon (IFN) and had been previously submitted to autologous stem cell transplantation were treated with imatinib for a median of 14 months (range: 6–19 months). Seven patients were in haematological response (HR) at the start of treatment; the remaining 26 attained a HR at a median of 3 weeks (range: 1–4 weeks). Major cytogenetic response rates at 3, 6 and 12 months were 42%, 45% and 55%, respectively, including 21%, 24% and 33% complete responses. Grade 3–4 neutropenia, thrombocytopenia and anaemia developed in 33%, 27% and 12% of patients respectively. Non‐haematological toxicity included superficial oedema (21% of patients), gastrointestinal symptoms (18%), muscle cramps (15%), skin rash and liver enzyme increase (3% each). These results were not significantly different from those in 65 chronic‐phase CML patients, resistant or intolerant to interferon without a previous ASCT, who were included in the same protocol. Imatinib mesylate is effective and safe in chronic‐phase CML patients with a previous history of intensive treatment.
A 0.2 V-1.8 V 8T SRAM with Bit-interleaving Capability

: An 8T SRAM with bit-interleaving capability is designed for ultra-dynamic voltage scaling applications. An adaptive body-biasing scheme is designed to improve the stability of 8T cell, which achieves 1.5 times higher noise margin compared to the non-body-biased 8T cell. Also, a write driver is presented to enable the bit-interleaving structure, thus achieving high soft-error tolerance. A prototype 1-kb SRAM is fabricated in a standard 0.18 µm CMOS process. The measurement results show that the proposed design ful ﬁ ls the functionality under supply voltage from 1.8 V to 0.3 V (0.2 V when the write wordline is boosted to 0.36 V) and the total power is reduced by four times of magnitude.
Seed Predation and Seedling Mortality in the Recruitment of a Shrub, Haplopappus venetus (Asteraceae), along a Climatic Gradient

Haplopappus venetus is a characteristic shrub of the coastal sage scrub of southern California. Its relative frequency decreases rapidly and significantly from the coast to the central valleys of southern California. Insect damage to developing flowers and seeds is high (35-61%). Experimental exclusion of predispersal flower and seed predators caused a significant increase in the number of viable seeds released because of: (I) a decrease in insect-caused abortion of flower heads (1 1%), (2) an increase in pollination success (19%), and (3) a decrease in damage to developing seeds (104%). A significant and proportionate increase in the number of seedlings established at sites over the climatic gradient from coast to inland valleys followed the exclusion of seed predators. In the inland area, however. extremely high mortality among established seedlings prevented recruitment of juveniles. Mortality of established adult plants, in contrast, was higher at the coast than inland (41 vs. 31%, respectively), suggesting that the geographic difference in the abundance of juveniles would persist. These results differ from those for a parallel experiment on H. squarrosus in which juvenile recruitment was determined by differential predispersal seed predation along the gradient and was not altered by differential mortality among seedlings. Consequently, I conclude that insect seed predation can be the critical factor limiting population recruitment, as in the case of H. squarrosus, but it need not be, as in the case of H. venetus. In the latter case, seedling mortality patterns, superimposed on seed predation, were critical to an explanation of plant recruitment and occurrence over the climatic gradient.
Natural History of the Minimally Abnormal Papanicolaou Smear

Objective We sought to determine the natural history of the cytologic and colposcopic changes in patients with minimal abnormalities on their Papanicolaou smears (atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion [SIL]). Methods Between November 1988 and November 1990, 632 women with abnormal Papanicolaou smears as listed above were evaluated at Los Angeles County-Olive View Medical Center. Each had review of cytology, repeat Papanicolaou smear, and colposcopy of the lower genital tract. We excluded those who were pregnant or had findings demonstrative of moderate dysplasia or worse, or had a cervical biopsy for any other indication. Women with symptomatic vaginal discharge were treated and remained in the study. Subjects were followed every 3 months with repeat Papanicolaou smear and colposcopy for a minimum of 9 months. If at any time the Papanicolaou smear or colposcopy was consistent with moderate dysplasia or worse, directed biopsies and endocervical curettage were performed, and treatment was given accordingly. Two hundred ninety-four patients fulfilled all inclusion criteria and had adequate follow-up data. Results Nine months after enrollment, 42 of 91 women (46.2%) with atypical squamous cells had persistent changes, none had progression, and 49 (53.8%) had regression to normal. In those with low-grade SIL, 37 of 203 cases (18.2%) persisted, seven (3.4%) progressed, and 159 (78.3%) regressed by 9 months. Patients in the first group were more likely to have persistence of the cytologic abnormalities than were those in the second (P < .01). Only the latter group progressed to high-grade dysplasia during the 9-month study interval. Conclusion The majority of women with confirmed minimal cytologic changes on Papanicolaou smear will have complete colposcopic and cytologic regression over a short interval.
GSR Responses to Fear-Related Stimuli

GSR responses to a set of tachistoscopically presented color slides were compared for 10 Ss who reported intense fear of spiders and 10 Ss admitting no unreasonable fears. Employing the index, ratio of response to spider-pictures over response to neutral stimuli (landscapes), perfect discrimination between the 2 groups of Ss was obtained.
Neurodevelopmental Outcome of Treatment of Symptomatic CMV Infection with Ganciclovir

Rationale: Cytomegalovirus (CMV) infection is a common cause for neurodisability among poor populations in developing countries, including Bangladesh. Some studies have shown that ganciclovir therapy is effective in reducing neurodevelopmental morbidity; while others remain equivocal. Objective : The objective of this study was to evaluate neurodevelopmental outcome of children with symptomatic CMV treated with ganciclovir compared to matched control. Methods: Out of 218 children seropositive for CMV admitted into the neurology ward between 2003-2006, 91 were treated with intravenous ganciclovir for 2-3 weeks; of whom 43 came for follow-up at an interval of 3 months to 1 year. At each visit neurodevelopmental status was recorded for cognition, vision and hearing. 41 untreated age-matched cases with follow-up records were retrospectively enrolled as control. Results: Among treated children compared to untreated controls, there was significant improvement in hearing (58% vs. 27%; p value=.012). Improvement remained consistent, without statistical significance, for vision (53% vs. 39%; p value=.071)) and cognition (51% vs. 54%; p value=.344). Conclusion: Ganciclovir treatment improved neurodevelopmental outcomes of very young children with symptomatic CMV infection. In a country where limited resources are available for children with disability, early recognition and treatment of CMV infection is recommended. DOI: http://dx.doi. org/10.3329/bjch.v35i3. 10498 Bangladesh J Child Health 2011; Vol 35 (3): 97-101
Effects of EGFR tyrosine kinase inhibitor erlotinib in prostate cancer cells in vitro

Erlotinib is a small‐molecule tyrosine kinase inhibitor targeted EGFR, known to be overexpressed in a variety of cancers, including prostate cancer. Clinical trials showed insignificant clinical benefit in patients with castration resistant prostate cancer both when EGFR inhibitors were administered as monotherapy or in association with antiandrogens or chemotherapeutics. Why, differently to other tumors, have EGFR inhibitors been so ineffective in human prostate cancer? This is the question that we have set in this report.
Third annual collaborative editing workshop

Collaborative editing systems support groups of people editing a document together over the computer network. People may work simultaneously on the same document, simultaneously on different copies of the document, or at different times on the original or copied document. The document types include text, diagrams, more complicated graphic objects, images, CAD drawings, multimedia, etc. Collaborative editing research addresses many fundamental and challenging issues facing the designers of real-time groupware systems in general.