Miracle-dz/UniFAR-FTUs huggingface dataset:
A Fast and Robust Deep Convolutional Neural Networks for Complex Human Activity Recognition Using Smartphone

As a significant role in healthcare and sports applications, human activity recognition (HAR) techniques are capable of monitoring humans’ daily behavior. It has spurred the demand for intelligent sensors and has been giving rise to the explosive growth of wearable and mobile devices. They provide the most availability of human activity data (big data). Powerful algorithms are required to analyze these heterogeneous and high-dimension streaming data efficiently. This paper proposes a novel fast and robust deep convolutional neural network structure (FR-DCNN) for human activity recognition (HAR) using a smartphone. It enhances the effectiveness and extends the information of the collected raw data from the inertial measurement unit (IMU) sensors by integrating a series of signal processing algorithms and a signal selection module. It enables a fast computational method for building the DCNN classifier by adding a data compression module. Experimental results on the sampled 12 complex activities dataset show that the proposed FR-DCNN model is the best method for fast computation and high accuracy recognition. The FR-DCNN model only needs 0.0029 s to predict activity in an online way with 95.27% accuracy. Meanwhile, it only takes 88 s (average) to establish the DCNN classifier on the compressed dataset with less precision loss 94.18%.
The RabGAP Gene Family in Tomato (Solanum lycopersicum) and Wild Relatives: Identification, Interaction Networks, and Transcriptional Analysis during Plant Development and in Response to Salt Stress

RabGTPase activating proteins (RabGAP) are responsible for directing the deactivation of vesicular trafficking master regulators associated to plant development, the RabGTPase proteins. Recently, RabGAPs were identified in Arabidopsis and rice, but studies were not yet reported in tomato. Herein, we identified 24 RabGAP-encoding genes in cultivated tomato (Solanum lycopersicum) and its wild relative genomes (Solanum pimpinellifolium and Solanum pennellii). We analyzed them based on their exon-intron structures, conserved protein motifs, putative subcellular localizations, phylogenetic and gene duplications analyses, interaction networks, and gene expression patterns in tomato. Phylogenetic relationship analysis also indicated that RabGAP family is classified into seven subclasses, of which subclasses I and II are plant-exclusive. Furthermore, segmental duplication events and positive evolutionary forces are associated with the maintenance of the number and function of their members. On the other hand, the protein–protein interaction networks on tomato suggested that members of subclasses I, II, and III could be associated to endocytic traffic routes. In addition, the qRT-PCR experiments in S. lycopersicum and Solanum chilense exposed to a salt stress treatment validated the differential expression patterns of 20 RabGAP genes in different tissues, development stages, and stress conditions obtained through extensive microarray-based analyses. This work suggests the critical role of RabGAP family in the context of intracellular vesicular trafficking in tomato, particularly under conditions of abiotic stress. It also contributes to the breeding programs associated with the development of crops tolerant to salt stress.
The Reason for Growth Inhibition of Ulmus pumila ‘Jinye’: Lower Resistance and Abnormal Development of Chloroplasts Slow Down the Accumulation of Energy

Ulmus pumila ‘Jinye’, the colorful leaf mutant of Ulmus pumila L. , is widely used in landscaping. In common with most leaf color mutants, U. pumila ‘Jinye’ exhibits growth inhibition. In this study, U. pumila L. and U. pumila ‘Jinye’ were used to elucidate the reasons for growth inhibition at the physiological, cellular microstructural, and transcriptional levels. The results showed that the pigment (chlorophyll a, chlorophyll b, and carotenoids) content of U. pumila L. was higher than that of U. pumila ‘Jinye’, whereas U. pumila ‘Jinye’ had a higher proportion of carotenoids, which may be the cause of the yellow leaves. Examination of the cell microstructure and RNA sequencing analysis showed that the leaf color and growth inhibition were mainly due to the following reasons: first, there were differences in the structure of the thylakoid grana layer. U. pumila L. has a normal chloroplast structure and clear thylakoid grana slice layer structure, with ordered and compact thylakoids. However, U. pumila ‘Jinye’ exhibited the grana lamella stacking failures and fewer thylakoid grana slice layers. As the pigment carrier and the key location for photosynthesis, the close stacking of thylakoid grana could combine more chlorophyll and promote efficient electron transfer promoting the photosynthesis reaction. In addition, U. pumila ‘Jinye’ had a lower capacity for light energy absorption, transformation, and transportation, carbon dioxide (CO2) fixation, lipopolysaccharide biosynthesis, auxin synthesis, and protein transport. The genes related to respiration and starch consumption were higher than those of U. pumila L. , which indicated less energy accumulation caused the growth inhibition of U. pumila ‘Jinye’. Finally, compared with U. pumila ‘Jinye’, the transcription of genes related to stress resistance all showed an upward trend in U. pumila L. That is to say, U. pumila L. had a greater ability to resist adversity, which could maintain the stability of the intracellular environment and maintain normal progress of physiological metabolism. However, U. pumila ‘Jinye’ was more susceptible to changes in the external environment, which affected normal physiological metabolism. This study provides evidence for the main cause of growth inhibition in U. pumila ‘Jinye’, information for future cultivation, and information on the mutation mechanism for the breeding of colored leaf trees.
Nasal Surgery May Improve Upper Airway Collapse in Patients With Obstructive Sleep Apnea: A Drug-Induced Sleep Endoscopy Study.

OBJECTIVE The aim of this study is to evaluate the effects of nasal surgery in the upper airway (UA) collapse using drug induced sleep endoscopy (DISE) in a group of patients with obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS Prospective cohort of patients treated with nasal surgery between 2015 and 2016. All patients were diagnosed with mild to severe OSAHS. The inclusion criteria were age between 18 and 70 years, apnea-hypopnea index (AHI) higher than 15, and septal deviation. All patients had a DISE performed before surgery and 3 months after. The DISE findings were evaluated through the NOHL scale. RESULTS Thirty-four patients were included. Surgical success with subjective and objective improvement in nasal obstructions was achieved in all cases. The pattern of UA obstruction did change significantly following nasal surgery (P < 0.05). Before nasal surgery, 74% of the patients demonstrated multilevel obstruction. After nasal surgery, only 50% patients showed multilevel collapse (P < 0.05). Among patients with single-level collapse, the oropharynx was the most common location of obstruction. It became more frequent after nasal surgery was done (41% vs 21%, P < 0.05). Significant improvement was shown in hypopharyngeal collapse. Postoperative AHI decreased from a mean of 26.7 to 19 events/h, but this change was not significant. CONCLUSION Nasal surgery may improve hypopharyngeal collapses observed during DISE in patients with OSAHS. Thus, an improvement in nasal obstruction may also modify the surgical plan based on UA functional findings in OSAHS patients.
Strain engineering of ferroelectric KNbO3 for bulk photovoltaic applications: an insight from density functional theory calculations

A large ferroelectric (FE) polarization and low bandgap are essential to improving the bulk photovoltaic response which is the generation of photocurrent in the polar non-centrosymmetric materials such as FE perovskite oxides. Among various perovskite oxides, Potassium Niobate (KNbO3, KNO) is a promising FE material for bulk photovoltaic applications as its bandgap and polarization can be tuned effectively by strain, doping, or by applying an electric field. In this work, using the density functional theory calculations, we present an insight into the strain engineering of polarization, band structure, and optical properties of the cubic (C), tetragonal (T), and orthorhombic (O) structures of KNO. The tensile and compressive strain under the triaxial, biaxial, and uniaxial conditions are applied along the direction parallel and perpendicular to the polar axis of KNO structures. We find that the bandgap decreases along with a substantial increment of polarization on the application of tensile strain along the direction parallel to the polar axis. In T (O) phase at +2% strain, the polarization increases by 18 µC cm−2 (14 µC cm−2) in triaxial, 26 µC cm−2 (16 µC cm−2) in biaxial, and 29 µC cm−2 (29 µC cm−2) in uniaxial conditions with a considerable decreasing of bandgap with respect to zero strain condition. Therefore, wisely applying the tensile strain along the direction parallel to the polar axis, the photovoltaic efficiency of KNO can be improved.
Association study of the PDE4D gene and obsessive-compulsive disorder in a Chinese Han population.

OBJECTIVE Multiple evidence suggests an involvement of the PDE4D in mental disorders. Therefore we investigate the association between obsessive-compulsive disorder and a polymorphism of the single nucleotide polymorphisms of PDE4D gene in the Chinese Han population. METHODS We genotyped and performed a case-control association analysis of the PDE4D polymorphism rs1838733 in 400 obsessive-compulsive disorder patients and 459 healthy control subjects. RESULTS The site conformed to Hardy-Weinberg (P > 0.05), three genotypes (AA, AG, GG) of PDE4D gene rs1838733 were detected. We demonstrated four principal results. First, there were no significant differences between the case and health controls in the genotype and allele at rs1838733 (P > 0.05). Second, there were no significant differences in the allele and genotype frequency between different genders obsessive-compulsive disorder (P > 0.05). Third, the genotype of single nucleotide polymorphism rs1838733 was associated with late-onset obsessive-compulsive disorder and female late-onset obsessive-compulsive disorder (P < 0.05). CONCLUSION The present study is the first to verify the associations of single nucleotide polymorphisms rs1838733 of the PDE4D gene with obsessive-compulsive disorder in a Chinese Han population. We found the genotype of single nucleotide polymorphism rs1838733 was associated with the occurrence of late-onset v and female late-onset obsessive-compulsive disorder. Therefore, PDE4D may play a role in the pathogenesis of obsessive-compulsive disorder and may become a potential target for obsessive-compulsive disorder treatment in future research. Further studies should verify the current findings.
Emerging Role of Genetic Alterations Affecting Exosome Biology in Neurodegenerative Diseases

The abnormal deposition of proteins in brain tissue is a common feature of neurodegenerative diseases (NDs) often accompanied by the spread of mutated proteins, causing neuronal toxicity. Exosomes play a fundamental role on their releasing in extracellular space after endosomal pathway activation, allowing to remove protein aggregates by lysosomal degradation or their inclusion into multivesicular bodies (MVBs), besides promoting cellular cross-talk. The emerging evidence of pathogenic mutations associated to ND susceptibility, leading to impairment of exosome production and secretion, opens a new perspective on the mechanisms involved in neurodegeneration. Recent findings suggest to investigate the genetic mechanisms regulating the different exosome functions in central nervous system (CNS), to understand their role in the pathogenesis of NDs, addressing the identification of diagnostic and pharmacological targets. This review aims to summarize the mechanisms underlying exosome biogenesis, their molecular composition and functions in CNS, with a specific focus on the recent findings invoking a defective exosome biogenesis as a common biological feature of the major NDs, caused by genetic alterations. Further definition of the consequences of specific genetic mutations on exosome biogenesis and release will improve diagnostic and pharmacological studies in NDs.
Measurement uncertainty of β-lactam antibiotics results: estimation and clinical impact on therapeutic drug monitoring

Abstract Background Despite that measurement uncertainty data should facilitate an appropriate interpretation of measured values, there are actually few reported by clinical laboratories. We aimed to estimate the measurement uncertainty of some β-lactam antibiotics (β-LA), and to evaluate the impact of reporting the measurement uncertainty on clinicians’ decisions while guiding antibiotic therapy. Methods Measurement uncertainty of β-LA (aztreonam [ATM], cefepime [FEP], ceftazidime [CAZ], and piperacillin [PIP]) values, obtained by an UHPLC-MS/MS based-method, was estimated using the top-down approach called the single laboratory validation approach (EUROLAB guidelines). Main uncertainty sources considered were related to calibrators’ assigned values, the intermediate precision, and the bias. As part of an institutional program, patients with osteoarticular infections are treated with β-LA in continuous infusion and monitored to assure values at least 4 times over the minimal inhibitory concentration (4×MIC). We retrospectively evaluated the impact of two scenarios of laboratory reports on clinicians’ expected decisions while monitoring the treatment: reports containing only the β-LA values, or including the β-LA coverage intervals (β-LA values and their expanded measurement uncertainties). Results The relative expanded uncertainties for ATM, FEP, CAZ and PIP were lower than 26.7%, 26.4%, 28.8%, and 25.5%, respectively. Reporting the measurement uncertainty, we identified that clinicians may modify their decision especially in cases where 4×MIC values were within the β-LA coverage intervals. Conclusions This study provides a simple method to estimate the measurement uncertainty of β-LA values that can be easily applied in clinical laboratories. Further studies should confirm the potential impact of reporting measurement uncertainty on clinicians’ decision-making while guiding antibiotic therapy.
LINC01198 promotes proliferation and temozolomide resistance in a NEDD4-1-dependent manner, repressing PTEN expression in glioma

Background: Dysregulation of numerous lncRNAs has been recently confirmed in glioma; however, the majority of their roles and mechanisms involved in this notorious disease remain largely unclear. This study aims to explore the roles and molecular mechanisms of LINC01198 implicated in the proliferation and chemoresistance in glioma. Results: LINC01198 was elevated in glioma, and this predicted a poorer prognosis for patients with glioma. LINC01198 knockdown inhibited, while LINC01198 overexpression promoted, glioma cell proliferation and resistance to temozolomide. Mechanistically, NEDD4-1 (neural precursor cell expressed, developmentally downregulated 4, E3 ubiquitin protein ligase) and phosphatase and tensin homolog (PTEN) were recruited by LINC01198, which functioned as a scaffold. Moreover, we showed that LINC01198 exerted its oncogenic activities by enhancing the NEDD4-1-dependent repression of PTEN. Conclusions: Our study elucidated the role of oncogenic LINC01198 in glioma proliferation and temozolomide resistance, and this role may serve as a promising target for glioma therapy. Methods: LINC01198 expression in glioma tissues and that in paired normal tissues were measured by qRT-PCR. The functional roles of LINC01198 in glioma were demonstrated by a series of in vitro experiments. CCK-8 assay, RNA pulldown, RNA immunoprecipitation and western blotting were used to demonstrate the potential mechanisms of LINC01198.
Chemopreventive Role of Curcumin in benzo ( A ) pyrene induced Lung Carcinogenesis in mice via-modulation of Bcl-2 , p 53 , Caspase-3 , Cyp 1 A 1 , COX-2 and antioxidant defense system in Lung tissues

Benzo(A)Pyrene [B(a)P] has been reported to cause lipid peroxidation and decrease antioxidant enzymes activities by inducing oxidative stress in lung carcinogenesis. Curcumin has exhibited chemopreventive potential against a variety of cancers, including lung cancer. The potential protective and chemopreventive effects of curcumin against [B(a)P] -induced lung cancer in mice were investigated. One hundred male Swiss Albino mice were divided into four equal groups. Group Ι: (Control group) received no drugs. Group Π: (lung cancerinduced) mice injected with a single dose of [B(a)P] (100 mg/ kg b.wt, i.p). Group III: (lung cancer + curcumin treated) mice injected with [B(a)P] and treated with curcumin (100 mg/kg b.wt/day, orally) from 22th to 30th weeks. Group IV: (lung cancer + curcumin protected) mice received curcumin on alternate days from 1 day prior to [B(a)P] injection and was treated continuously with curcumin until 30th week. Blood and lung tissue samples were collected for determination of serum CEA, Haptoglobin (HPT), adenosine deaminase (ADA) and ɤ-GT, antioxidants enzymes (CAT, SOD, GPx, GST and GR), L-MDA, NO, GSH, Bcl-2, CYP1A1, P53, Caspase 3, DNA fragmentation and COX-2 in lung tissues. The obtained results revealed that, [B(a)P] potentially increased serum CEA, HPT, ADA, ɤGT in addition to COX-2, Caspase 3, L-MDA, NO, Bcl-2, CYP1A1, P53, and DNA fragmentation in lung tissues. However, enzymatic antioxidants status and GSH were significantly decreased. It could be concluded that, curcumin may be effective in reducing lung cancer by its radical scavenging activity and anti-inflammatory effect, regenerating endogenous antioxidant mechanisms and decreased caspase-3 and DNA fragmentation and attenuate Bcl-2, P53, CYP1A1 and COX -2 in lung tissues. These results indicate the possible efficiency of curcumin as a distinct chemopreventive agent in lung carcinogenesis.
Fertility trajectories and later-life depression among parents in England

We examine pathways between indicators of fertility tempo/quantum and depressive symptoms among parents aged 55+ with at least two children, using three waves of the English Longitudinal Study of Ageing. Using standard regression approaches and path analysis within the structural equation framework, we also investigate whether fertility trajectories mediated the association between childhood disadvantage and later-life depression. Results provide limited support for direct influences of fertility trajectories on depression, but indicate indirect linkages for both women and men. Associations are mediated by partnership history, social support, wealth, later-life smoking, and functional limitation. Associations between childhood disadvantage and later-life depression are partially mediated by fertility stressors. Results confirm the influence of life course experiences on depression at older ages and demonstrate the interlinked role of family and other life course pathways on later-life well-being.
Bio-Based PBT–DLA Copolyester as an Alternative Compatibilizer of PP/PBT Blends

The aim of this work was to assess whether synthesized random copolyester, poly(butylene terephthalate-r-butylene dilinoleate) (PBT–DLA), containing bio-based components, can effectively compatibilize polypropylene/poly(butylene terephthalate) (PP/PBT) blends. For comparison, a commercial petrochemical triblock copolymer, poly(styrene-b-ethylene/butylene-b-styrene) (SEBS) was used. The chemical structure and block distribution of PBT–DLA was determined using nuclear magnetic resonance spectroscopy and gel permeation chromatography. PP/PBT blends with different mass ratios were prepared via twin-screw extrusion with 5 wt% of each compatibilizer. Thermogravimetric analysis, differential scanning calorimetry, and dynamic mechanical analysis were used to assess changes in phase structure of PP/PBT blends. Static tensile testing demonstrated marked improvement in elongation at break, to ~18% and ~21% for PBT–DLA and SEBS, respectively. Importantly, the morphology of PP/PBT blends compatibilized with PBT–DLA copolymer showed that it is able to act as interphase modifier, being preferentially located at the interface. Therefore, we conclude that by using polycondensation and monomers from renewable resources, it is possible to obtain copolymers that efficiently modify blend miscibility, offering an alternative to widely used, rubber-like petrochemical styrene compatibilizers.
Effect of deprogramming splint and occlusal equilibration on condylar position of TMD patients – A CBCT assessment

ABSTRACT Objective: Assessment of clinical symptoms and condylar position of TMD patients using CBCT imaging with deprogramming splint therapy and occlusal equilibration. The hypothesis tested was the alleviation of symptoms of TMD with possible changes in condylar position occurs with this treatment. Methods: The condylar position of 12 TMD patients was observed from CBCT images, and clinically, symptom severity score, mouth opening, and range of motion were compared pre- and post-treatment. Results: All patients reported a statistically significant decrease in the symptom severity score and increase in mouth opening and range of motion (p < .05). A significant decrease was only achieved in the left anterior joint space (p < .05). Conclusion: Deprogramming splint therapy and occlusal equilibration benefitted patients with a reduction in clinical symptoms, and minor changes in condylar position were observed.
Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly

Significance Axon initial segments of vertebrate neurons integrate thousands of dendritic inputs and generate a single outgoing action potential. Giant ankyrin-G associates with most of the molecular components of axon initial segments and is required for their assembly. This study identified 3 human mutations of giant ankyrin-G resulting in impaired neurodevelopment in compound heterozygotes. These mutations prevent transition of giant ankyrin-G from a closed to an open conformation, which normally is regulated by phosphorylation of giant ankyrin-G during maturation of axon initial segments. Giant ankyrin-G thus functions in a signaling pathway that may contribute to activity-dependent plasticity of the axon initial segment as well as provide a therapeutic target for treatment of patients bearing giant ankyrin-G mutations. Giant ankyrin-G (gAnkG) coordinates assembly of axon initial segments (AISs), which are sites of action potential generation located in proximal axons of most vertebrate neurons. Here, we identify a mechanism required for normal neural development in humans that ensures ordered recruitment of gAnkG and β4-spectrin to the AIS. We identified 3 human neurodevelopmental missense mutations located in the neurospecific domain of gAnkG that prevent recruitment of β4-spectrin, resulting in a lower density and more elongated pattern for gAnkG and its partners than in the mature AIS. We found that these mutations inhibit transition of gAnkG from a closed configuration with close apposition of N- and C-terminal domains to an extended state that is required for binding and recruitment of β4-spectrin, and normally occurs early in development of the AIS. We further found that the neurospecific domain is highly phosphorylated in mouse brain, and that phosphorylation at 2 sites (S1982 and S2619) is required for the conformational change and for recruitment of β4-spectrin. Together, these findings resolve a discrete intermediate stage in formation of the AIS that is regulated through phosphorylation of the neurospecific domain of gAnkG.