Miracle-dz/UniFAR-FTUs huggingface dataset:
Robotic endoscopic surgery of the skull base: a novel surgical approach.

OBJECTIVE To describe a novel robotic surgical approach that allows adequate endoscopic access for resection of tumors involving the anterior and central skull base and allows 2-handed, tremor-free, endoscopic dissection and precise suturing of dural defects. DESIGN Transnasal endoscopic approaches are being increasingly used for surgical access and resection of tumors of the anterior and central skull base. One major disadvantage of this approach is the inability to provide watertight dural closure and reconstruction, which limits its safety and widespread adoption in surgery of intracranial skull base tumors. Other disadvantages include limited depth perception and several ergonomic constraints. Four human cadaver specimens were used for this study. The surgical approach starts with bilateral sublabial incisions and wide anterior maxillary antrostomies (Caldwell-Luc). Transantral access to the nasal cavity is gained through bilateral wide middle meatal antrostomies. A posterior nasal septectomy facilitates bilateral access by joining both nasal cavities into 1 surgical field. The da Vinci Surgical System is then "docked" by introducing the camera arm port through the nostril and the right and left surgical arm ports through the respective anterior and middle antrostomies, into the nasal cavity. A 5-mm dual-channel endoscope coupled with a dual charge-coupled device camera is inserted in the camera port and allows for 3-dimensional visualization of the surgical field at the surgeon's console. Using the robotic surgical arms, the surgeon may perform endoscopic anterior or posterior ethmoidectomy, sphenoidotomy, or resection of the middle or superior turbinates depending on the extent of needed surgical exposure. In addition, resection of the cribriform plate is performed robotically with sharp dissection of the skull base. The dural defect is then repaired with a 6-0 nylon suture. RESULTS Adequate access to the anterior and central skull base, including the cribriform plate, fovea ethmoidalis, medial orbits, planum sphenoidale, sella turcica, suprasellar and parasellar regions, nasopharynx, pterygopalatine fossa, and clivus, was obtained in all cadaveric dissections. The 3-dimensional visualization obtained by the dual-channel endoscope at the surgeon's console provided excellent depth perception. The most significant advantage was the ability of the surgeon to perform 2-handed tremor-free endoscopic closure of dural defects. CONCLUSIONS Transantral robotic surgery provides adequate endoscopic access to the anterior and central skull base. To our knowledge, this is the first study to report the feasibility and advantages of robotic-assisted endoscopic surgery of the skull base. This novel approach also allows for 3-dimensional, 2-handed, tremor-free endoscopic dissection and precise closure of dural defects. These advantages may expand the indications of minimally invasive endoscopic approaches to the skull base.
Gonadotropin-releasing hormone (GnRH) analog suppression renders polycystic ovarian disease patients more susceptible to ovulation induction with pulsatile GnRH.

Pulsatile GnRH administration consistently restores normal reproductive hormone levels and ovulation in women with hypogonadotropic hypogonadism, but is less effective in those with polycystic ovarian disease (PCOD). We pharmacologically created a hypogonadotropic condition with a GnRH analog (GnRH-A) in six women with PCOD to investigate the role of deranged gonadotropin secretion in PCOD and to improve the response to pulsatile GnRH ovulation induction. Before GnRH and GnRH-A treatment the women with PCOD had increased LH pulse frequency [one pulse every 55 +/- 2 (+/- SE) min; P less than 0.05] and LH pulse amplitude (10.9 +/- 1.4 U/L; P less than 0.05) compared to normal women in the follicular phase of their menstrual cycle. Each PCOD woman completed one cycle of pulsatile GnRH administration for ovulation induction before (pre-A cycles; n = 6) and one or two cycles after (post-A cycles; n = 9) GnRH-A administration [D-Ser(tBu)6-Des,Gly10-GnRH; 300 micrograms, sc, twice daily for 8 weeks]. Pulsatile GnRH (5 micrograms/bolus) was given at 60-min intervals using a Zyklomat pump. Daily blood samples were drawn during the pulsatile GnRH ovulation induction cycles for the determination of serum LH, FSH, estradiol (E2), progesterone, and testosterone, and pelvic ultrasonography was done at 1- to 4-day intervals. Mean (+/- SE) serum LH levels were elevated during the pre-A cycle (49.2 +/- 3.1 IU/L) and decreased to normal levels during the post-A cycles (19.6 +/- 1.4 IU/L; P less than 0.0001). Mean testosterone concentrations were lower during the post-A cycles [88 +/- 2 ng/dL (3.1 +/- 0.1 nmol/L)] than during the pre-A cycles [122 +/- 3 ng/dL (4.2 +/- 0.1 nmol/L); P less than 0.0001]. In the follicular phase of the post-A cycles E2 levels were significantly lower [81 +/- 5 pg/mL (300 +/- 20 pmol/L) vs. 133 +/- 14 pg/mL (490 +/- 50 pmol/L); P less than 0.0001], preovulatory ovarian volume was smaller (24.6 +/- 2.0 vs. 31.4 +/- 2.4 cm3; P less than 0.01), and the FSH to LH ratio was higher (0.56 +/- 0.03 vs. 0.16 +/- 0.01) than in the pre-A cycle, suggesting more appropriate function of the pituitary-gonadal axis. Excessive LH and E2 responses to pulsatile GnRH administration in the early follicular phase of the pre-A cycle were abolished in the post-A cycles. (ABSTRACT TRUNCATED AT 400 WORDS)
Gender wage discrimination across Portuguese territory and its local determinants

Discrimination practices against women within the labour market are widely common and a matter of great concern for academics, policymakers and the society at large. Focusing on wage discrimination practices, this study aims at understanding the role that demand factors play in explaining the wage discrimination gap in Portugal. Using a rich matched employer-employee data set Quadros de Pessoal we explore cross-regional variations to identify the role of labour demand on the gender wage gap. Estimating a mincerian wage equation that accounts for worker, rm and job characteristics, the empirical estimates revealed a total hourly wage discrimination gap of -13.6 log points in mainland, varying from -0.4 to -24.4 log points across Portuguese counties. This reinforces the existence of a territorial heterogeneity in wage discrimination practices that enables us to use county variations to identify the impact of local labour market forces on the wage discrimination gap. Regarding the demand side factors, the regression results at the county level showed that municipalities with a higher share of workers in the secondary sector exhibit a larger discrimination gap. Contrarily, counties with a higher share of workers employed in micro establishments and with a higher share of minimum wage earners exhibit a smaller discrimination gap. On the labour supply side, the results revealed a positive impact of the youth activity rate (from 25 to 34 years old) on the discrimination gap, i.e., employers in counties with a higher supply of workers aged 25-34 seem to have more room to discriminate against women. Fi-
Cerebral Small Vessel Disease and Motoric Cognitive Risk Syndrome: Results from the Kerala-Einstein Study.

BACKGROUND The contribution of cerebral small vessel disease to cognitive decline, especially in non-Caucasian populations, is not well established. OBJECTIVE We examined the relationship between cerebral small vessel disease and motoric cognitive risk syndrome (MCR), a recently described pre-dementia syndrome, in Indian seniors. METHODS 139 participants (mean age 66.6 ± 5.4 y, 33.1% female) participating in the Kerala-Einstein study in Southern India were examined in a cross-sectional study. The presence of cerebral small vessel disease (lacunar infarcts and cerebral microbleeds (CMB)) and white matter hyperintensities on MRI was ascertained by raters blinded to clinical information. MCR was defined by the presence of cognitive complaints and slow gait in older adults without dementia or mobility disability. RESULTS Thirty-eight (27.3%) participants met MCR criteria. The overall prevalence of lacunar infarcts and CMB was 49.6% and 9.4% , respectively. Lacunar infarcts in the frontal lobe, but no other brain regions, were associated with MCR even after adjusting for vascular risk factors and presence of white matter hyperintensities (adjusted Odds Ratio (aOR): 4.67, 95% CI: 1.69-12.94). Frontal lacunar infarcts were associated with slow gait (aOR: 3.98, 95% CI: 1.46-10.79) and poor performance on memory test (β: -1.24, 95% CI: -2.42 to -0.05), but not with cognitive complaints or non-memory tests. No association of CMB was found with MCR, individual MCR criterion or cognitive tests. CONCLUSIONS Frontal lacunar infarcts are associated with MCR in Indian seniors, perhaps, by contributing to slow gait and poor memory function.
Book review: Singh, L., Joseph, K. and Johnson, D., editors. 2015: Technology, Innovations and Economic Development: Essays in Honour of Robert E. Evenson

Singh, L. , Joseph, K. and Johnson, D. , editors. 2015: Technology, Innovations and Economic Development: Essays in Honour of Robert E. Evenson. London: SAGE. xxxv + 335 pp. £42.00 (Hardback). ISBN: 978-93-515-0269-2.
Multicolorful Carbon Dots for Tumor Theranostics.

BACKGROUND Cancer is a great threat of human health worldwide due to the uncontrollable spread of malignant cells throughout the body. Accurate diagnosis and targeted therapy approaches are critical factors for cancer treatment. Combination of therapeutic and diagnostic agents in a single nanocarrier enables to simultaneously monitor the cancer progression and tune disease therapy with minimum side effect. OBJECTIVE Carbon dots are a novel class of small fluorescence carbon nanostructures with size less than 10 nm at least in one dimension, which exhibit excellent optical properties, larger surface area to volume ratio and low toxicity. The unique properties of carbon dots make it as an ideal carrier for incorporation of cancer targeting moieties, bio-imaging agents and antineoplastic agents in one delivery system. METHODS An literature search was conducted using Web of Science to find out articles related to carbon dots and tumor theranostics. RESULTS Numerous applications of carbon dots in cancer theranostics have been reported during the past 10 years. This review introduces a brief history and basic fluorescent properties of carbon dots, and then discusses synthesis strategies and applications of carbon dots in biological imaging, targeted anti-cancer drug delivery, photodynamic therapy, photothermal therapy as well as gene delivery for cancer theranostics. Future directions of carbon dots in cancer theranostics are also highlighted.
Redispatching Active and Reactive Powers Using a Limited Number of Control Actions

This paper deals with some essential open questions in the field of optimal power flow (OPF) computations, namely: the limitation of the number of controls allowed to move, the trade-off between the objective function and the number of controls allowed to move, the computation of the minimum number of control actions needed to satisfy constraints, and the determination of the sequence of control actions to be taken by the system operator in order to achieve its operation goal. To address these questions, we propose approaches which rely on the computation of sensitivities of the objective function and inequality constraints with respect to control actions. We thus determine a subset of controls allowed to move in the OPF, by solving a sensitivity-based mixed integer linear programming (MILP) problem. We study the performances of these approaches on three test systems (of 60, 118, and 618 buses) and by considering three different OPF problems important for a system operator in emergency and/or in normal states, namely the removal of thermal congestions, the removal of bus voltage limits violation, and the reduction of the active power losses.
Essays in Earnings, Academic Productivity, and School Competition

This thesis consists of three self-contained essays evaluating current issues in earnings, academic productivity, and school competition. The first chapter, coauthored with Anindya Sen, looks at returns to post-secondary education and the gender gap in Ontario. We construct a unique individual level panel dataset consisting of earnings of public sector employees of the Government of Ontario, facilitated by the Ontario Salary Disclosure Act which reveals earnings of $100,000 or more. Individual earnings from 2005-2013 were merged with publicly available profiles on www.linkedin. com, which contains details on educational attainment, field of study, job experience, and specific occupation. There are significant field specific differences in returns to post-secondary education. In terms of graduate education, on average, while Ph.D.’s earn a premium relative to undergraduates, there is a modest gender gap in earnings of doctoral degree holders, which is not present among undergraduates. The sample period also experienced significant salary increases for female undergraduates. However, there are significant gender differences in the proportion of individuals who are managers and also in earnings of senior managers belonging to early cohorts. By creating and utilizing a unique panel data from several different sources including the Ontario Ministry of Finance, EconLit, Web of Science, Online CVs, and so forth on all tenured and tenure track professors in 16 Ontario economic departments over 1996 to 2012, the second chapter intends to analyze the pay and position of those professors to see how co-authorship affect an economist’s research productivity and how research productivity impacts pay and promotion. The study demonstrates that there is a significant return to co-authored publications relative to solo-authored publications in Ontario universities. The investigation of the relationship between co-authorship and productivity reveals that co-authored publications are associated with higher citation counts. Our research has also demonstrated that higher quality publications have a greater effect on salary, and the likelihood of promotion is positively associated with past performance. The estimates also suggest that some gender differences exist concerning the impact of co-authored publications on the likelihood of promotion. Finally, we find that in Ontario, economists are more likely to co-author with their colleagues,who have the similar ability, experience, and research interest. We found no gender-sorting effect among Ontario economists. In the last chapter, I use a data set obtained from the Ontario Ministry of Education and the Educational Quality and Accountability office (EQAO) to estimate whether average school performance is affected by competition from other nearby schools. The availability of data on a panel of schools allows me to control for the potentially confounding effects
Doppler predictors of inducibility of atrial fibrillation in patients with WPW syndrome and atrioventricular re-entrant tachycardia

Background — Atrial fibrillation (AF) in patients with Wolff-Parkinson-White syndrome (WPW) may induce complex ventricular arrhythmias resulting in sudden cardiac death. It is essential to find an effective non-invasive diagnostic method allowing to select patients at risk of life-threatening arrhythmias. Our objective was to examine Doppler predictors of AF in patients with WPW and atrioventricular re-entrant tachycardia (AVRT). Material and methods — 65 patients with WPW and AVRT (33 men, mean age 39 ± 11y) were prospectively studied. In all patients TTE was performed with measurements of left ventricle (LV) diameters, volumes and parameters of systolic and diastolic function.TTE was followed by invasive electrophysiology study (EPS) and radiofrequency current ablation of accessory pathway. AF lasting at least 30 s was induced in 29 (44.6%) patients during EPS. Reduction of right upper pulmonary vein (RUPV) systolic velocity (P < 0.005) and systolic to diastolic velocity ratio (P < 0.005) and increase in atrial reversal velocity (P < 0.05) of RUPV flow and difference between duration of RUPV atrial reversal flow and A wave of mitral profile (P < 0.05) were associated with increased risk of AF in patients with WPW syndrome and AVRT. Systolic and atrial reversal velocities were identified as independent predictors of AF in those patients. Conclusions — Systolic and atrial reversal right upper pulmonary vein flow velocities have been shown to be independent predictors of AF inducibility in patients with Wolff-Parkinson-White syndrome and atrioventricular re-entrant tachycardia.
Hartmann wavefront sensors and their application at FLASH.

Different types of Hartmann wavefront sensors are presented which are usable for a variety of applications in the soft X-ray spectral region at FLASH, the free-electron laser (FEL) in Hamburg. As a typical application, online measurements of photon beam parameters during mirror alignment are reported on. A compact Hartmann sensor, operating in the wavelength range from 4 to 38 nm, was used to determine the wavefront quality as well as aberrations of individual FEL pulses during the alignment procedure. Beam characterization and alignment of the focusing optics of the FLASH beamline BL3 were performed with λ(13.5 nm)/116 accuracy for wavefront r.m.s. (w(rms)) repeatability, resulting in a reduction of w(rms) by 33% during alignment.
The importance of hand use to discharge of interpositus neurones of the monkey.

1. Monkey interpositus neurones show large discharge modulations during reaching to grasp, however, the same neurones show little or no modulation during operation of devices that exercise individual forelimb joints. We tested the hypothesis that grasping during the reach‐to‐grasp is necessary for eliciting high discharge modulation. 2. Three monkeys (Macaca mulatta) moved an articulated lever between low and high target zones. While in the lower zone the monkey's hand was at its waist, in the upper zone its hand was in a position that required forelimb extension at right‐angles to the body axis. Small drawers adjacent to the target zones contained raisins, and the drawers could be remotely opened. Thus, we could elicit two types of reaches having similar trajectories: one reach involved limb transport while holding the lever handle, and the other involved limb transport while forming the hand to grasp a raisin. 3. Eighty‐one neurones from two monkeys, mostly from interpositus with some from adjacent regions of dentate, were tested during device use and reaching to grasp: 93% of the neurones discharged at high rates during at least one of the tasks. Of these, about half increased discharge rate solely during reaching to grasp; the other half showed some increase during device use but only discharged strongly during reaching to grasp. Overall, discharge modulations during the reach‐to‐grasp averaged twice as high as during the corresponding device movement (112 versus 56 impulses s‐1). 4. Individual neurones consistently discharged with characteristic patterns during the reach‐to‐grasp with rates often exceeding 300 impulses s‐1. Discharge during the reach‐to‐grasp was independent of reach trajectory: discharge patterns and amplitudes were similar when reaching from either the lower or upper target zone to the upper raisin drawer as when reaching from the upper target zone to the upper raisin drawer. Reach direction also made little difference: reaches from the upper target zone to the lower drawer typically elicited similar discharge modulation as those from the lower target zone to the upper drawer. 5. High discharge rates associated with grasping were independent of the item being grasped: typically, grasping the device handle elicited as high discharge rates as grasping a raisin. 6. The hypothesis was confirmed that grasping is critical for eliciting high discharge modulation in interpositus during reaching to grasp. Discharge pattern and modulation do not vary with reach direction or amplitude of the reach and, therefore, it is unlikely that intermediate cerebellum controls these features of the reach‐to‐grasp. (ABSTRACT TRUNCATED AT 400 WORDS)
Smad7 blocks transforming growth factor-β1-induced gingival fibroblast-myofibroblast transition via inhibitory regulation of Smad2 and connective tissue growth factor.

BACKGROUND Transforming growth factor-β1 (TGF-β1), its downstream signaling mediators (Smad proteins), and specific targets, including connective tissue growth factor (CTGF), play important roles in tissue remodeling and fibrosis via myofibroblast activation. We investigated the effect of overexpression of Smad7, a TGF-β1 signaling inhibitor, on transition of gingival fibroblast to myofibroblast. Moreover, we analyzed the participation of CTGF on TGF-β1-mediated myofibroblast transformation. METHODS To study the inhibitory effect of Smad7 on TGF-β1/CTGF-mediating gingival fibroblast transition into myofibroblasts, we stably overexpressed Smad7 in normal gingival fibroblasts and in myofibroblasts from hereditary gingival fibromatosis (HGF). Myofibroblasts were characterized by the expression of the specific marker isoform α of the smooth muscle actin (α-SMA) by Western blot, flow cytometry, and immunofluorescence. Enzyme-linked immunosorbent assay for type I collagen was performed to measure myofibroblast activity. CTGF's role on myofibroblast transformation was examined by enzyme-linked immunosorbent assay and small interference RNA. RESULTS TGF-β1 induced the expression of α-SMA and CTGF, and small interference RNA-mediating CTGF silencing prevented fibroblast-myofibroblast switch induced by TGF-β1. In Smad7-overexpressing fibroblasts, ablation of TGF-β1-induced Smad2 phosphorylation marked decreased α-SMA, CTGF, and type I collagen expression. Similarly, HGF transfectants overexpressing Smad7 demonstrated low levels of α-SMA and phospho-Smad2 and significant reduction on CTGF and type I collagen production. CONCLUSIONS CTGF is critical for TGF-β1-induced gingival fibroblast-myofibroblast transition, and Smad7 overexpression is effective in the blockage of myofibroblast transformation and activation, suggesting that treatments targeting myofibroblasts by Smad7 overexpression may be clinically effective in gingival fibrotic diseases, such as HGF.
WORKING PAPER SERIES: WPS/0027 Statistical Modelling of Second Round Qualification at FIFA World Cup Tournaments

In this paper, we model the predictors of second round qualification at FIFA World Cup tournaments. We utilize data covering the last four tournaments namely 2002, 2006, 2010 and 2014. We employ the methodology of Norton et al. (2004) to estimate the predictors. Also, we establish how the significance of these predictors differs across the participating continents. In addition, we determine the likelihood of single continent and continent pair dominance in the second round stage. We hope to revisit these findings as new rules unfold and notable changes that may alter the existing trend become evident.