Miracle-dz/UniFAR-FTUs huggingface dataset:
The use of digital channels to create customer relationships

The interest in relationship marketing and especially relationship dynamics among academics and practitioners is growing. The focus is on expanding maintaining relationships to the whole relationship life cycle, including relationship initiation. However, research concerning relationships in a digital context or in a context where customer-company interactions occur through technology interfaces is scarce. To our knowledge there is no research on how the relationships begin in such a context. This paper explores the role of digital channels in the creation of customer relationships. Digital channels denote methods for customer-company interactions through technology interfaces such as e-mail, Short Message Service (SMS), and webpages. An exploratory qualitative study was conducted with business executives. The findings indicate that identifying relationship initiation is challenging and that the initiation differs between Business-to-Business (B2B) and Business-to-Customer (B2C) relationships. Digital and interpersonal contacts are frequently used simultaneously in creating customer relationships. Digital marketing activities such as search engine advertisements and direct e-mails are important. The paper integrates a digital perspective to relationship dynamics research. It contributes to e-service research by focusing on relationship dynamics. It also extends relationship marketing research by exploring relationship initiation.
Which Ad Works, When, Where, and how Often? Modeling the Effects of Direct Television Advertising

The authors develop a model to decompose the effects of television advertising for a toll-free referral service, at the hourly level. The model estimates which ad works, when, in which station, and for how long. Results of the analysis show that ads do stimulate direct response, but their effects dissipate very rapidly. Effectiveness and profitability vary substantially by creative, television station, and station x time of the day. The results underscore the need for managers to undertake such analyses and for researchers to use such a disaggregate approach.
Herding Behavior of Lenders in P2P Lending Markets and Its Rational Test:Evidence from PaiPaiDai Market

Online P2Plending market is different from traditional credit market due to multiple lenders,prominent social aspect of lending,and the great uncertainty when judging a borrower's creditworthiness.Using data from PaiPaiDai online market,we tested lenders' investment decisions.Our result shows:There is prominent herding behavior in P2Plending market,which means the potential lenders' investment decisions are positively influenced by their peers;Besides,instead of mimicking their peers' decisions passively,the potential lenders take both a listing's risk attributes and peers' investment decisions into consideration,which is testified to be rational herding.
A STUDY OF PERSISTENT METOPIC SUTURE IN DRY SKULLS IN CENTRAL INDIA

Address for Correspondence: Dr. Sameer Sathe, HIG A-16, PCMS Campus, Peoples Medical College, Bhanpur, Bhopal (MP), Pin 462037, India. E-Mail: ansh251103@yahoo.co.in Introduction: Metopic suture is present between developing frontal bones. It disappears approximately by 2-3 years and latest by 8 years of age. The persistence of this suture is termed as metopism. It may persist normally without any clinical implications. However, it may be confused with skull fracture in Post mortem studies or on imaging studies. Clinically it may be present in few genetic or metabolic disorders. Materials and Methods: This study was conducted on 70 human adult dry skulls. The skulls were inspected at the Norma Frontalis for the presence of the Metopic suture. The sutures were classified as complete and incomplete types. Observations and Results: Out of 70 skulls studied, a complete metopic suture was found in 2 skulls (2.85%), whereas an incomplete suture was observed in 3 skulls (4.28%). The remaining 65 skulls (92.85 %) of the skulls did not show any metopic suture. Conclusion: The present study showed the incidence of metopic sutures in adult skulls of central India. The present study is clinically useful in the fields of Radiology and Medicolegal purposes.
Determinants of stunting: The role of education, information and childcare practices in Mozambique DRAFT

Stunting prevalence rates in Mozambique are very high (41 percent), especially in rural areas (46 percent). Recent research shows that consumption growth alone will not be sufficient to solve the problem of malnutrition. To investigate the role of other determinants of stunting I use a two step approach with specific attention to the role of childcare knowledge and practices, education and access to information. In rural areas I find that the positive effect of mother’s education works entirely through its effect on better childcare knowledge and practices, which then have a positive effect on anthropometric outcomes. Hence, continuous investment in girls’ education will lead to better childcare practices and better anthropometrics in areas where community services are in short supply and household level practices play a more important role. In the shortterm the education channel may be complemented by improving mothers’ knowledge through other information channels such as radio programmes or direct visits by health workers. * Department of Economics, University of Copenhagen. All comments highly welcome. Please send to kvdb@econ.ku. dk The work was initially prepared as a background paper to the Mozambique Poverty, Social and Gender Assessment while working at the World Bank in Maputo.
Bank Merger in Mexico Post Crisis 1994, Under the Vision of the Resource-Based Theory

The strength of the companies is sustained in the resources that it owns, that can be considered like a barrier to the entrance for other companies, these resources can be tangible and intangible, the case of the baking sector these resources were affected by the crisis of 1994, devastated with the anti-crisis measures and the entrance of foreign competitors at the end of the 90´s decade, under this surroundings we analyze the acceleration of the concentration at the Mexican banking system based on the theory based on the resources. The central problem is how these resources accelerated the concentration of the banking sector and the lack of a strategy to face the new challenge. To have competitive advantages in resources and a solid global expansion strategy, foreign banks were able to climb to a position in the Mexican banking system, with the subsequent generation of barriers to entry to maintain its leadership.
On the role of monoamine oxidase for the inactivation of dopamine in brain.

Evidence is presented that monoamine oxidase is involved in the metabolism of dopamine in brain. Thus 3,4-dihydroxyphenylacetic acid has been demonstrated to occur in the brains of three species investigated, including man. That this acid was derived from dopamine after oxidative deamination seemed probable as it was found to be localized in the same areas of the brain as dopamine and it disappeared after inhibition of monoamine oxidase with iproniazid. The capacity of this enzyme in brain seemed to be sufficient for the plausible inactivation rate of dopamine in this tissue.
Vertical Relationships and Financial Performance of Brazilian Companies in the Electricity Distribution Supplier Sector (2001-2003)

Competition and the quest for competitive advantages on the market are prompting companies to reshape the profiles of their relationships with their customers and suppliers. They are opting for approaches based more on cooperation, trust, loyalty and quality, instead of bargaining power or clout that that might well be used by vertical scope participants as a way opportunistically pressuring these relationships. Based on the constructs of Durand (1999), this paper investigated the relationship between the possibility of substituting relationships with suppliers and buyers, viewed as resources by companies in the power generator, transformer, electric motor and control and distribution equipment sectors, and the financial and market performance of these firms, grounded on a resource-based view. The findings demonstrated that the less substitutable their relationship with customers, the worst the financial performance of the companies in the target sectors. Inversely, the less substitutable the relationships with their main suppliers, the better their financial performance. Financial performance was measured by the following variables: return on assets, operating margin or return on sales and the profits generation capacity rating. Based on the homogeneity and specific characteristics of the target sectors, the findings may be explained by other theories, such as the Transaction Costs Theory and the industrial organisation itself, as noted by Porter (1980) and often neglected. These findings will certainly direct the academic community towards new research projects and reflections, in addition to offering a contribution to studies involving non-financial variables that affect the value creation of the companies, which is an international trend.
Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas

The current treatment strategies for glioblastoma have limited health and survival benefits for the patients. A common obstacle in the treatment is chemoresistance. A possible strategy to evade this problem may be to combine chemotherapeutic drugs with agents inhibiting resistance mechanisms. The aim with this study was to identify molecular pathways influencing drug resistance in glioblastoma-derived cells and to evaluate the potential of pharmacological interference with these pathways to identify synergistic drug combinations. Global gene expressions and drug sensitivities to three chemotherapeutic drugs (imatinib, camptothecin and temozolomide) were measured in six human glioblastoma-derived cell lines. Gene expressions that correlated to drug sensitivity or resistance were identified and mapped to specific pathways. Selective inhibitors of these pathways were identified. The effects of six combinations of inhibitors and chemotherapeutic drugs were evaluated in glioblastoma-derived cell lines. Drug combinations with synergistic effects were also evaluated in non-cancerous epithelial cells. Four drug combinations had synergistic effects in at least one of the tested glioblastoma-derived cell lines; camptothecin combined with gefitinib (epidermal growth factor receptor inhibitor) or NSC 23766 (ras-related C3 botulinum toxin substrate 1 inhibitor) and imatinib combined with DAPT (Notch signaling inhibitor) or NSC 23766. Of these, imatinib combined with DAPT or NSC 23766 did not have synergistic effects in non-cancerous epithelial cells. Two drug combinations had at least additive effects in one of the tested glioblastoma-derived cell lines; temozolomide combined with gefitinib or PF-573228 (focal adhesion kinase inhibitor). Four synergistic and two at least additive drug combinations were identified in glioblastoma-derived cells. Pathways targeted by these drug combinations may serve as targets for future drug development with the potential to increase efficacy of currently used/evaluated chemotherapy.
A hexapod walking machine with decoupled freedoms

Legged locomotion over irregular terrain is composed of body-propelling motion and terrain-adapting motion. Although conventional walking machines with three degrees-of-freedom for each leg can adapt their feet on irregular ground using flexible leg freedom, such machines generally require a tremendously complex control scheme for the body-propelling motion. A walking machine with decoupled freedoms is based on the idea that body-propelling motion is realized by only one degree-of-freedom, and this freedom can be perfectly decoupled from the freedoms for terrain adaptability. As an application of such a walking machine, a hexapod walking machine using an approximate straight line mechanism was developed and several basic experiments were performed to demonstrate the properties of this type of walking machine.
The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing*

Inhibitor of apoptosis (IAP) proteins are widely expressed throughout nature and suppress cell death under a variety of circumstances. X-linked IAP, the prototypical IAP in mammals, inhibits apoptosis largely through direct inhibition of the initiator caspase-9 and the effector caspase-3 and -7. Two additional IAP family members, cellular IAP1 (cIAP1) and cIAP2, were once thought to also inhibit caspases, but more recent studies have suggested otherwise. Here we demonstrate that cIAP1 does not significantly inhibit the proteolytic activities of effector caspases on fluorogenic or endogenous substrates. However, cIAP1 does bind to caspase-3 and -7 and does so, remarkably, at distinct steps prior to or following the removal of their prodomains, respectively. Indeed, cIAP1 bound to an exposed IAP-binding motif, AKPD, on the N terminus of the large subunit of fully mature caspase-7, whereas cIAP1 bound to partially processed caspase-3 in a manner that required its prodomain and cleavage between its large and small subunits but did not involve a classical IAP-binding motif. As a ubiquitin-protein isopeptide ligase, cIAP1 ubiquitinated caspase-3 and -7, concomitant with binding, in a reaction catalyzed by members of the UbcH5 subfamily (ubiquitin carrier protein/ubiquitin-conjugating enzymes), and in the case of caspase-3, differentially by UbcH8. Moreover, wild-type caspase-7 and a chimeric caspase-3 (bearing the AKPD motif) were degraded in vivo in a proteasome-dependent manner. Thus, cIAPs likely suppress apoptosis, at least in part, by facilitating the ubiquitination and turnover of active effector caspases in cells.
Creating sustainable futures by innovation from within. Radical change is in demand of radical innovation

We are currently in a crisis (e.g. climate change, the breakdown of the financial system, species extinction, worldwide poverty, etc.). Some claim this a ‘crisis of crisis’. Others refer to the current state as a ‘systemic crisis’ and the momentum of a great bifurcation. This raises the question whether or not we will have the opportunity of choice to change at the very moment of the bifurcation. Are we able to provide an innovation design that does not only address the problems but that enables involved stakeholders to anticipate their interconnected sustainable futures? We argue that prevailing innovation design approaches have fundamental shortcomings. We suggest to rethink and redesign – not to re-engineer – these innovation processes, if we want to address effectiveness rather than efficiency, radical and at the same time profound and sustainable innovation rather than incremental innovation.
Job Search Institutions and Job Match Quality

We examine empirically the impacts of time-limited unemployment insurance (UI) and active labor market programs (ALMP) on the duration and outcome of job search. We find that time invested in job search normally pays off in the form of higher earnings once a job match is formed. But jobs accepted close to UI exhaustion are of significantly lower quality than jobs accepted earlier in the search process. Participation in ALMP raises the probability of eventually finding a job as well as the level of expected earnings, but at the cost of lengthening job search. The programs are cost-effective under realistic assumptions regarding the value of within-program production.
A Survey of Big Data in Social Networking and Media Interaction

Data is orgin of the any system. Data continue their scaling at various types. Achieving an automated system in digital media world deals with massive amounts of data that collect over the time in www. It was updated every second around the world using social networks. Social networks provide the opportunity to connect as personnel, professional and entertained. This survey is aims to demonstrate the massive amount of data utilization in social networking and media recommendation. There are varieties of social networking websites are available in www. Main objective of this survey is to how people are connected with social networks and how TV media are utilizing the social networks to rate the programs and channel.
Central administration of melanin-concentrating hormone increases alcohol and sucrose/quinine intake in rats.

BACKGROUND Alcohol is a caloric compound that can contribute to energy intake. Therefore, peptides that regulate energy balance likely modify the motivation to consume alcohol. Melanin-concentrating hormone (MCH) regulates energy homeostasis and has been implicated in other behaviors that impact alcohol consumption (i.e., anxiety, fluid balance, and reward). We tested the hypothesis that MCH would decrease the motivation to consume alcohol secondarily to reducing anxiety. METHODS Rats were trained to drink 10% ethanol or an isocaloric concentration of sucrose with use of a sucrose-fading technique. MCH (1, 5, or 10 microg) or its saline vehicle was administered into the third cerebral ventricle (i3vt), and intake of ethanol or sucrose and chow was assessed for 2 hr. Alcohol-naïve rats were evaluated in an elevated plus maze after i3vt MCH (10 microg), neuropeptide Y, or saline administration. RESULTS Contrary to the hypothesis, MCH dose-dependently increased alcohol intake: saline = 0.7 +/- 0.1 g/kg, 1 microg MCH = 1.0 +/- 0.1 g/kg, 5 microg MCH = 1.2 +/- 0.1 g/kg, and 10 microg MCH = 1.8 +/- 0.3 g/kg (p < 0.01), and this was true whether water was simultaneously available or not. MCH also significantly increased sucrose intake (saline = 1.0 +/- 0.3 g/kg, 10 mug MCH = 1.4 +/- 0.5 g/kg; p < 0.05). MCH had no effect on time spent in the open arms (54.3 +/- 11.5 sec) relative to saline (58.2 +/- 23.8 sec), whereas neuropeptide Y, a known anxiolytic, increased time spent on the open arms (119.2 +/- 22 sec, p < 0.05). CONCLUSIONS We conclude that MCH nonspecifically increases ingestive behavior. Furthermore, MCH had no apparent effect on anxiety. The ability of MCH to increase alcohol and/or sucrose intake may be explained by the effect of MCH on energy balance and/or reward processes.
ACCOUNTING FOR CARING AND ACCOUNTABILITY IN THE INSTITUTIONALIZATION OF COMPETITIVE TENDERING

This paper analyses how the institutionalization of competitive tendering during procurement of public health care services affects budgetary accountability of public decision makers. Competitive tendering in welfare States, such as Finland, has brought considerable capital market pressures into the ways of thinking and doing of public decision makers. Local and multinational corporations have received a niche in which to use their innovative and production skills as a source of power to compete for resources that are in the hands of public decision makers. In the institutional change, the traditional decision making process, previously dominated by political and legal rationalities, in public sector organizations, was expected to switch to sound business minded ways of handling public procurement bids, offers and contracts dominated by capital market mechanisms. Previous literature documents major institutional change failures. How various circuits of power involved in public procurement processes affect budgetary accountability of public decision makers, however, remain an under-researched accounting field. This paper fills this gap by extending the institutional conceptual framework of management accounting change proposed by Burns and Scapens (2000) to the framework of circuits of power proposed by Clegg (1989). A practical motivation is to show how practitioners and policy makers can enhance accountability of public decision makers through the institutionalization of public procurement mechanisms whose outcomes in terms of costs and service quality they can control. Findings, based on intensive field research over a period of 4 years in regional city in Finland, confirm the theoretical reasoning of the paper with policy implications.
The Cyclin E/Cdk2 Substrate p220NPAT Is Required for S-Phase Entry, Histone Gene Expression, and Cajal Body Maintenance in Human Somatic Cells

ABSTRACT Cyclin E/Cdk2, a central regulator of the G1/S transition, coordinates multiple cell cycle events, including DNA replication, centrosome duplication, and activation of the E2F transcriptional program. Recent studies suggest a role for cyclin E/Cdk2 in activation of histone transcription during S phase via the Cajal body-associated protein p220NPAT, and in addition, p220 can promote S-phase entry independently of histone transcriptional activation when overexpressed. Here we have examined the requirement for p220 in histone transcription, cell cycle progression, and Cajal body function through analysis of human somatic HCT116 cells engineered to contain a conditional p220 allele. p220 is required for proliferation of HCT116 cells, as assessed after expression of Cre recombinase in p220flox/− cells. This defect was due to an inability of these cells to transit from G0/G1 into S phase, and cell cycle arrest occurred in the presence of elevated Cdk2 kinase activity. Expression of human papillomavirus E7, but not E6, eliminated cell cycle arrest in response to p220 depletion. Optimal expression of all four core histone genes required p220, as did optimal transcription of a histone H4 promoter-luciferase construct. Basal histone H4 expression in G0/G1, although p220 dependent, occurs in the absence of detectable phosphorylation of p220 on Cdk2 sites. Cells lacking p220 displayed defects in the localization of the Cajal body component p80coilin as cells progressed from G0 to S phase in response to mitogenic signals. These finding indicate that p220 is an essential downstream component of the cyclin E/Cdk2 signaling pathway and functions to coordinate multiple elements of the G1/S transition.
Studies on the function of two adjacent N6, N6-dimethyladenosines near the 3' end of 16S ribosomal RNA of Escherichia coli. IV. The effect of the methylgroups on ribosomal subunit interaction

The effect of the presence or absence of the methylgroups of the m2(6)Am2(6)A sequence near the 3' end of 16S rRNA of Escherichia coli on the interaction of the ribosomal subunits has been studied, using wild-type (methylated) and mutant (unmethylated) ribosomes. Subunit exchange experiments and competitive association experiments show a strong preference of the 50S subunit for association with methylated 30S subunits. The results indicate that the equilibrium constant of the reaction 70S in equilibrium with 30S + 50S is dependent on the methylgroups; mutant 30S.50S couples are less stable than wild-type 30S.50S couples. It is postulated that the methylgroups also stimulate the interaction between 30S subunits and initiation factor IF-3.