Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of oestrogen receptor and oestrogen‐inducible genes ps2 and erd5 in large bowel mucosa and cancer

Since there is a preponderance of large bowel cancer in males, both in humans and in experimental models, and hormone replacement therapy is protective, a role for sex steroid hormones in the pathogenesis of this neoplasm seems likely. Evidence of functional oestrogen receptor has been looked for in large bowel mucosa and cancer. Expression of oestrogen receptor, and of the oestrogen‐inducible receptor‐associated genes pS2 and ERD5, was sought. Oestrogen receptor mRNA was detected in cancers and paired normal mucosae in equal amounts. In situ hybridization identified stromal cells above the muscularis mucosae that were positive for oestrogen receptor mRNA. pS2 mRNA was also detected, with a signal intensity significantly higher in normal mucosa compared with cancers, whereas the reverse was seen with ERD5 mRNA levels. pS2 and ERD5 were expressed in epithelium, with the former in a greater amount in distal colon and rectum than proximal colon. Although oestrogen‐inducible and receptor‐associated genes are expressed in large bowel mucosa, their expression does not correlate with oestrogen receptor. © 1998 John Wiley & Sons, Ltd.
Enterprise Energy Management from a Practical Perspective: A Case Study of Anyang Iron and Steel Enterprise

With the rapid development of “The Belt and Road Initiative”, China has made many improvements in cutting overcapacity and increasing the energy efficiency. As a result, the successful and effective practices of energy management and energy conservation and emission reduction of some Chinese enterprises can be beneficial for other countries along the Belt and Road to learn and use for reference. In this sense, this paper studies the enterprise energy management practice by studying and analyzing the example of Anyang Iron and Steel Enterprise. In the study, five subsystems including energy policy and objectives, energy management structure, consciousness of energy saving, energy information management and management practice in process level and three energy-saving methods consisting of technical method, managerial method and structural method are studied in details in order to understand the real situation of energy management practice in the iron and steel firm. Based on the above, it also summarizes ten useful industrial energy management principles. As a result, this study of energy management practice, on one hand, offsets the lack of literature review to some degree, on the other hand, it summaries the experience and principles of energy management in Anyang Iron and Steel Enterprise benefiting for other enterprises to learn from and make future improvements.
Multiparticle correlations in complex scattering and the mesoscopic Boson Sampling problem

We consider the many-body scattering of non-interacting identical particles in mesoscopic chaotic cavities. A complete enumeration of all interfering paths allows us to discriminate single-particle effects from many-body interference due to quantum indistinguishability. In the thermodynamic limit of large particle number massive quantum interference results in a macroscopic, coherent manifestation of many-body correlations. We also incorporate mesoscopic dephasing, present even when the particles scatter simultaneously. Under further simplifications characteristic for optical scenarios, our methods can be used to address open issues related to the Boson Sampling problem.
An efficient method for the field uniformity analysis of anechoic chambers

An efficient geometric optics (GO) method is successfully developed for the field uniformity (FU) analysis and converted to an in-house computer-aided design (CAD) software tool for anechoic chamber design. It can help anechoic chamber companies to select the right radio absorbing materials for a chamber to meet the desired specs. Simulation and measurement results are obtained and compared, and good agreement is obtained. It is shown that this method is accurate and efficient for chamber simulation, especially at high frequencies.
One-year outcomes of women started on antiretroviral therapy during pregnancy before and after the implementation of Option B+ in Malawi: A retrospective chart review.

OBJECTIVE To compare one-year outcomes of women started on antiretroviral therapy (ART) during pregnancy in the pre-Option B+ era to those in the Option B+ era. METHODS A retrospective chart review was performed at three sites in Malawi. Women were included in the 'pre-Option B+' cohort if they started ART during pregnancy for a CD4 count < 350 cells/mm3 or WHO 3/4 condition and in the 'Option B+' cohort if they started ART during pregnancy regardless of CD4 count or clinical stage. One-year outcomes were compared using Fisher's exact and ANOVA F-tests. RESULTS A higher proportion of women in the pre-Option B+ cohort started ART at WHO stage 3/4 (11.9% versus 1.1%, P < 0.001), switched ART regimens (5.9% versus 0%, P = 0.002), or died in the first year after starting treatment (3.9% versus .5%, P = 0.05). While more women in the Option B+ cohort had poor adherence or defaulted, these differences were not significant. CONCLUSIONS At our study sites, the transition to Option B+ has been associated with ART initiation in women with less advanced HIV infection, improved medication tolerability, and lower mortality. Further research is needed to better understand outcomes of Option B+.
Identification of Itk/Tsk Src Homology 3 Domain Ligands*

The tyrosine kinase Itk/Tsk is a T cell specific analog of Btk, the tyrosine kinase defective in the human immunodeficiency X-linked agammaglobulinemia and in xid mice. T lymphocytes from Itk-deficient mice are refractory to mitogenic stimuli delivered through the T cell receptor (TCR). To gain insights into the biochemical role of Itk, the binding properties of the Itk SH3 domain were examined. An optimal Itk SH3 binding motif was derived by screening biased phage display libraries; peptides based on this motif bound with high affinity and selectivity to the Itk SH3 domain. Initial studies with T cell lysates indicated that the Itk SH3 domain bound Cbl, Fyn, and other tyrosine phosphoproteins from TCR-stimulated Jurkat cells. Under conditions of increased detergent stringency Sam 68, Wiskott-Aldrich Syndrome protein, and hnRNP-K, but not Cbl and Fyn, were bound to the Itk SH3 domain. By examining the ability of different SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP.
An understanding of the electronic bipolar resistance switching behavior in Cu / TiO 2 / ITO structure

In this study, TiO2 films and devices were prepared by sol-gel method. The bipolar resistive switching phenomena was observed in the Cu/TiO2/ITO device. The conduction mechanism of devices were analyzed. It was found that the conduction mechanism is dominated by space charge limited current in high resistance state, and Schottky emission in low resistance state.
AN IMPACT OF ANIMAL BREED ON THE COMPOSITION OF FATTY ACIDS IN MUSCULUS LONGISSIMUS DORSI

The aim of the research was to assess the breed impact on the composition of fatty acids in the musculus longissimus dorsi comparing 500-day-old bulls bred under the same conditions. The study investigated the structure of fatty acids in musculus longissimus dorsi of the following cattle breeds: Angus, Hereford, Charolaise, Limousin, Lithuanian black and white crossbred with Charolais (LBW x CH), Lithuanian black and white crossbred with Limousines (LBW x LI), Lithuanian black and white crossbred with Simmental (LBW x SI), and the Lithuanian red Limousines hybrids (LR x LI). The breed had the most significant impact on the total amount of monounsaturated and total amount of omega-6 fatty acids (p<0.05, p<0.05). There were significant differences determined in average values of omega–3 fatty acids (p<0.05) depending on breed. A lower ratio of omega-6/ omega-3 fatty acids was observed in pure-bred bulls. The meat of pure-bred bulls contained a slightly larger amount of saturated fatty acids compared to the crossbred bulls. There was a strong correlation between polyunsaturated / saturated fatty acids ratio and the amount of omega – 3, when r = 0.934. The amounts of trans-fatty acid isomers were not affected by breed (p≥0.05). The research results revealed that cattle breed affects the composition of fatty acids in the muscular longissimus dorsi.
Genetics , genome-wide association study , and genetic improvement of dairy fertility traits 1

Before fertility traits were incorporated into selection, dairy cattle breeding primarily focused on production traits, which resulted in an unfavorable decline in the reproductive performance of dairy cattle. This reduced fertility is constantly challenging the dairy industry on the efficiency and sustainability of dairy production. Recent development of genomic selection on fertility traits has stabilized and even reversed the decreasing trend, showing the effectiveness of genomic selection. Meanwhile, genome-wide association studies (GWAS) have been performed to identify quantitative trait loci (QTL) and candidate genes associated with dairy fertility, providing a better understanding of the genetic architecture of fertility traits. In this review, we provide an overview of the genetics of fertility traits, summarize the findings from existing GWAS of female fertility in dairy cattle, and update the recent research progress in US dairy cattle. Because of the polygenic nature of fertility traits, many GWAS of dairy fertility tended to be underpowered. Only 1 major QTL, on BTA18, was identified across multiple studies. This QTL was associated with a range of fertility traits from conception to calving, but the candidate gene or mutation is still missing. Collectively, with the promising success from genomic selection but low power of GWAS on dairy fertility traits, this review calls for continuous data collection of fertility traits to enable more powerful studies of dairy fertility in the future.
Magnetic Tunnel Junctions with an Al and Al-Hf-Al Oxide Barrier Formed by Ozone Oxidation

Magnetic tunnel junctions (MTJs) with the barrier oxidized by ozone were studied. Tunnel magnetoresistance (TMR) ratio of about 30 % in the junctions with an ozone oxidized barrier is almost the same as those with plasma oxidized barrier. However, junction resistance of the ozone oxidized specimen was one order magnitude lower than that of plasma oxidized one. The plasma free oxidation process could eliminate the possible structural damage by an oxygen ion bombardment and give improved control over the tunnel barrier. In addition to this, we have modified the oxide barrier by forming Hf oxide layer in the middle of Al oxide. The junctions with Hf-inserted barrier show higher TMR ratio and weaker temperature dependence than those with the conventional Al oxide barrier. The enhancement of TMR by the introduction of Hf layer might be due to the reduction of defects in the barrier.
X‐linked Charcot‐Marie‐Tooth disease with novel c.47A>T GJB1 gene mutation

Dear Editor, With interest we read the research report on genetic analysis in Serbian patients with CharcotMarie-Tooth (CMT) disease (Keckarevic-Markovic et al., 2009). The authors report five novel GJB1 (connexin32) gene mutations in X-linked CMT (CMTX1), and among these was a single case with a c.47A>T (p.His16Leu, Reference sequence NM 000166.5) mutation. CMTX1 has been associated with a c.47A>C (p.His16Pro) mutation at the same codon in the GJB1 gene (Bone et al., 1997), listed in the inherited peripheral neuropathies mutation database (http://www.molgen.ua.ac.be/CMTMutations). However, in the absence of a pedigree that demonstrates segregation of the mutation only in affected family members, the possibility of genetic polymorphism cannot be ruled out. We recently found the c.47A>T (p.His16Leu) GJB1 mutation in a family of Turkish origin. The proband was a woman aged 26 (II-1 in Table 1) who presented with pain radiating from the neck into the arms, paresthesias in the fingers and feet, muscle cramps, and exertional fatigability of the limbs. The neurological examination was normal. Nerve conduction studies showed an axonal polyneuropathy. Extensive laboratory investigations and cerebrospinal fluid analysis were normal. Sural nerve biopsy revealed mild loss of large myelinated nerve fibres, some axonal degeneration, and few clusters of regenerating axons. Onion bulb formations were not prominent, but thin myelinated fibres enveloped by up to two Schwann cell sheath layers (pseudo-onion bulbs) were observed more frequently. There were no signs of inflammatory infiltration or vascular inflammation. Although there appeared to be no other affected family members, a tentative diagnosis of CMT was made for which at that time (prior to 1993) genetic analysis was not possible. She was
Expression and polymorphism of ADAM32 gene and its association with somatic cell count in Holstein-Friesian cows

The aims of this study were to confirm ADAM32 gene expression in selected bovine tissues and identify potentially functional polymorphisms within the 5’flanking region. The associations between the polymorphism within ADAM32 and somatic cell count in the Holstein-Friesian cow’s milk were examined. Expression studies of ADAM32 in different tissues performed by RT-PCR revealed the presence of the ADAM32 transcript in the liver, mammary and pituitary gland and leukocytes, except for monocytes. Comparative sequencing analysis of 870 bp PCR amplicons obtained from four different Bos taurus breeds and the Bison bonasus fragment of the ADAM32 5’ flanking region showed a 21 bp insertion/deletion at position -541 nt to -520 nt and the occurrence of seven SNPs. In silico analysis of the 1180 bp 5’ flanking region of ADAM32 indicated that the 21 bp deletion abolished putative binding sites for six transcription factors associated with the immune system. A population of one hundred and two Polish Holstein-Friesian bulls and 241 cows progeny of 15 heterozygous (InsDel) sires were screened. The frequency of genotypes (for sires) were observed at 0.765, 0.235, 0.0 for DelDel, InsDel and InsIns, respectively, whereas for cows the frequencies are as follows: 0.365, 0.510 and 0.125. The association study performed within the group of daughters of heterozygous sires revealed that cows with the DelDel genotype showed significantly higher somatic cell counts than those with the InsIns genotype (P=0.013). No significant association was found between cows’ genotypes and milk production traits.
A varying patient safety profile between black and nonblack adults with decreased estimated GFR.

BACKGROUND Chronic kidney disease is a high-risk condition for a variety of adverse safety events, yet little is known about differential rates of safety events across racial groups with decreased kidney function. We sought to examine the incidence of an array of disease-specific adverse safety events in black versus nonblack patients with decreased estimated glomerular filtration rate (eGFR). STUDY DESIGN Retrospective observational study of a national US Veterans Affairs cohort. SETTINGS & PARTICIPANTS Veterans with eGFR <60 mL/min/1.73 m(2) and one or more hospitalization during federal fiscal year 2005 (n = 70,154). PREDICTOR Self-reported race/ethnicity dichotomized as black or nonblack. OUTCOMES Hospital discharge coding for Agency for Healthcare Research and Quality (AHRQ) patient safety indicators (PSIs), laboratory records for detection of hyperkalemia and hypoglycemia, and pharmacy records to determine dosing of 4 selected medications. MEASUREMENTS Relationship between race and disease-specific patient safety events. RESULTS Black veterans were more likely than nonblack veterans to experience one type of safety event (33% vs 32%, respectively) and multiple types of safety events (32% vs 23%, respectively; both P < 0.001). After adjustment, black veterans were 11% and 36% more likely to have at least one episode of hyperkalemia and hypoglycemia, respectively, than nonblack veterans, but were 14% less likely to experience a medication error (all P < 0.001). There was no association between the occurrence of AHRQ PSIs and race after adjustment. LIMITATIONS Use of administrative data has a risk of imprecision in coding; Veterans Affairs cohort may limit generalizability. CONCLUSIONS Black veterans with decreased eGFR are more likely to experience a broad array of safety events than nonblacks with decreased eGFR, with a preponderance of metabolic disturbances rather than medication errors or AHRQ PSIs. The differential safety phenotype in blacks versus nonblacks may have implications for preventive strategies to improve patient safety in an integrated health care system.
Decision making with and without feedback: The role of intelligence, strategies, executive functions, and cognitive styles

We investigated the effects of intelligence, decision-making strategies, and general cognitive styles on the role of feedback in making decisions under risk. A total of 100 healthy volunteers were assessed with the Game of Dice Task (GDT). A total of 50 participants performed the original GDT, and 50 participants performed a modified GDT in which no feedback was provided. A neuropsychological test battery and questionnaires assessing strategy application and cognitive styles were administered to all participants. Participants who performed the original GDT had higher net scores than those who performed the modified GDT. The benefit of feedback was moderated by participants' intelligence and strategy application.
Species and Size Composition of Seahorses ( Genus Hippocampus , Family Syng nathidae ) in the Coastal Waters and Local Market of Kota Kinabalu

Seahorse diversity (Genus Hippocampus, Family Syngnathidae), species identification, size composition and sexual diphormism were conducted from November 2012 to March 2013 in selected coastal waters around Kota Kinabalu, Sabah and local market trade. Six species of seahorses were identified in the study: (1) Hippocampus barbouri, (2) H. comes, (3) H. kelloggi, (4) H. kuda, (5) H. spinosissimus and (6) H. trimaculatus. All six species were sold at the local market and the dried seahorses were obtained mainly by local fishermen using trawl by-catch method and traded as traditional medicine, souvenirs and other uses. By direct samplings, four species: (1) H. barbouri, (2) H. comes, (3) H. kuda, and (4) H. spinosissimus were identified in various different habitats of Kota Kinabalu coastal waters. Based on the result, H. comes was the largest in size among the four fresh/live species found (147-150, 148.25±1.26mm), whereas H. barbouri was the smallest species (118-140, 129±7.81mm). For the dried samples, H. kelloggi was the largest (218-265mm, 245.25±14.55 mm) and H. barbouri was the smallest (105-142mm, 127.21±10.01 mm). From statistics, no significance difference (P>0.05) was observed in lengths between male and female in every seahorse species and there was no sexual size dimorphism in any of the species. The findings from the study are significant in providing several baseline data for marine conservation purposes of the unique seahorses.
Is the cortical blindness due to diaschisis?

Cortical blindness is defined as a loss of vision that is caused by bilateral occipital lobe lesions. Many reports of patients with cortical blindness describe bilateral occipital lesions visualized on morphologic and functional imaging studies. The authors present the case of a patient who became cortically blind after a hemorrhagic lesion of the right occipital lobe. CT failed to reveal bilateral occipital involvement, but the brain SPECT showed decreased perfusion of both parleto-occipital areas. The brain SPECT findings correlated better with the clinical status. SPECT may be more useful than CT for detecting functional brain abnormalities, and the clinical and imaging findings of the present patient could be attributed to the transhemispheric diaschisis.
Dose escalation of low molecular weight heparin to manage recurrent venous thromboemblic events despite systemic anticoagulation in cancer patients.

e20580 Background: Cancer patients with venous thromboembolism (VTE) are at high risk of recurrent VTE. The rate of recurrent VTE ranges from 9 to 17% despite therapy with low molecular weight heparins (LMWH) or vitamin K antagonists (VKA) respectively. To date, no published evidence is available to guide treatment of cancer patients with recurrent VTE. We sought to evaluate the benefit and risk of LMWH dose escalation in cancer patients with recurrent VTE. METHODS Retrospective cohort study was conducted in consecutive cancer outpatients referred for management of an objectively confirmed, symptomatic, recurrent VTE while receiving an anticoagulant. Patients were treated with either dose escalation of weight-adjusted LMWH in patients already anticoagulated with LMWH or initiation of a therapeutic dose LMWH in patients who were taking a VKA. All patients were followed for a minimum of 3 months after the index recurrent VTE. RESULTS Seventy cancer patients with a recurrent VTE despite ongoing anticoagulation were included. The median time between the initial VTE to the index recurrence was 3.5 months (range 0.3 to 193 months). At the time of the recurrence, 67% of patients were on LMWH, while 33% were on VKA. Following the treatment with either dose escalation or initiation of LMWH, a total of 6 patients (8.6%; 95% confidence interval (CI): 4.0% to 17.5%) had a second recurrent VTE during the three-month follow-up period, at an event rate of 9.9 per 100 patient-years (95% CI: 2.0 to 17.8). The median time between the index and second recurrent VTE was 1.9 months (range 0.6 to 3.0 months). One patient (1.4%; 95% CI: 0.3% to 7.7%), or 1.6 per 100 patient-years (95% CI: 0.0% to 4.8%) of follow-up, had a major bleeding event. The median time between the index recurrent VTE to death was 11.4 months (range 0 to 83.9 months). CONCLUSIONS Patients with recurrent VTE have a poor prognosis. Escalating the dose of LMWH can be effective for treating cases that are resistant to standard, weight-adjusted doses of LMWH or a VKA. [Table: see text].