Miracle-dz/UniFAR-FTUs huggingface dataset:
Sea-Level Highstand Chronology from Stable Carbonate Platforms (Bermuda and The Bahamas)

A history of sea-level highstands representing the past 1.2 my is assembled from geological and geo-chronological data from Bermuda and the Bahamas. Outcrops of marine and eolian limestones exhibit sea-level indicators on tectonically stable islands. Because of the low-lying nature of the islands, they preserve a record of both highstand (limestone) and lowstand (paleosol) events. Geomorphology and sequence stratigraphy are critical for ranking deposit age, while U-series, amino acid racemization (AAR), electron spin resonance (ESR), and paleomagnetics have provided absolute and relative age estimates. In Bermuda, two early Pleistocene marine sequences are estimated to be > 700 ka and > 880 ka. The younger of the two is associated with a + 22 m marine terrace cut into the older Walsingham Fm, which exposes marine limestones at < + 5 m a.s. l. During the latter half of the middle Pleistocene (Stages 11, 9, and 7; 500 to 180 ka), sea level rose above the present at least three times to approximately +4 m, +4m, and +2.5 m, respectively. Stage 5e includes at least two major positive oscillations of sea level (early at +4 m and late at ≥+6 m). The two 5e marine units are separated by an extensive, rubified protosol, interpreted as evidence of a minor regression (interstadial) of several thousand years. The late Sangamonian (Southampton Fm) is characterized by an extensive skeletal eolianite on high-energy shorelines, offlapped by a - 1 m to + 1 m marine deposit dated at ca. 85 ka. There is no evidence to support a Holocene sea level rising significantly above the present datum. Unlike tectonic coastline and isotopic studies that require major assumptions of constant uplift and temperature/ice-volume/salinity in order to calculate ancient sea levels, precise elevations of paleo-seduced can be obtained from deposits on stable carbonate platforms. Regardless, the inexact models provided by deep-sea oxygen isotope and U-series dating of uplifted reef terraces are valuable to establish a framework for the timing, duration and relative magnitude of Quaternary high sea levels.
Anticoagulant Treatment of HIT Recent guidelines from the American College of Chest Physicians

Due to familiarity, short half-life, ease of monitoring, and the availability of a reversal agent, heparin remains the anticoagulant of choice for cardiac operations requiring cardiopulmonary bypass (CPB). However, occasionally patients require CPB but should not receive heparin, most often because of acute or subacute heparin-induced thrombocytopenia (HIT). In these cases, if it is not feasible to wait for the disappearance of HIT antibodies, an alternative anticoagulant must be selected. A number of non-heparin anticoagulant options have been explored. However, current recommendations suggest the use of a direct thrombin inhibitor such as bivalirudin. This review describes the use of heparin alternatives for the conduct of CPB with a focus on the direct thrombin inhibitors.
Transplant Rejection TLR Signals Promote IL-6/IL-17-Dependent

Acute allograft rejection has often been correlated with Th1 differentiation, whereas transplantation tolerance is frequently associated with induction of regulation. The discovery of the Th17 phenotype has prompted its scrutiny in transplant rejection. Although IL-17 has recently been observed in settings of acute allograft rejection and drives rejection in T-bet-deﬁcient mice that have impaired type 1 T cell responses, there is little evidence of its requirement during acute rejection in wild-type animals. We and others have previously shown that TLR9 signaling by exogenous CpG at the time of transplantation is sufﬁcient to abrogate anti-CD154-mediated acceptance of fully mismatched cardiac allografts. In this study, we investigated the mechanism by which acute rejection occurs in this inﬂammatory context. Our results indicate that CpG targets recipient hemopoietic cells and that its pro-rejection effects correlate both with prevention of anti-CD154-mediated conversion of conventional CD4 (cid:1) T cells into induced regulatory T cells and with the expression of IFN- (cid:2) and IL-17 by intragraft CD4 (cid:1) T cells. Moreover, the combined elimination of IL-6 and IL-17 signaling abrogated the ability of CpG to promote acute cardiac allograft rejection. Thus, proinﬂammatory signals at the time of transplantation can change the quality of the effector immune response and reveal a pathogenic function for IL-6 and IL-17 in wild-type recipients. The Journal of Immunology, 2009, 182: 6217–6225. suppression. In addition, TLR signals may prevent iTreg generation in anti-CD154 mAbs-treated recipients by further antagonizing the development of dominant suppression, thereby resulting in allograft rejection. The purpose of our study was to identify the mechanisms of action of CpG by studying the effects of CpG on iTregs and monitoring the impact of TLR9 signaling on effector T cells and mechanisms of rejection. Our results demonstrate that CpG targets hemopoietic cells of recipient origin and promotes acute cardiac allograft rejection in a novel manner that depends on IL-6 and IL-17 and is distinct from acute rejection in untreated wild-type recipients.
Emergency evacuation of people with disabilities: A survey of drills, simulations, and accessibility

Abstract A natural or man-made disaster may destabilize the structure of a building and endanger the lives of its occupants. Evacuating occupants in the shortest possible time is the first reaction in such situations, often referred to as indoor emergency evacuation. Indoor emergency evacuations pay little attention to people with disabilities (PWD) who face additional challenges in emergency situations than people without disabilities. This work highlights the major findings in literature with regard to emergency evacuation of PWD and underscores the related shortcomings and gaps for future research. Current studies can be categorized in: evacuation drills, computer evacuation models, and indoor accessibility measures for PWD. Evacuation drills are focused on assessing the ability of PWD to negotiate different surface types and bottlenecks, but none on understanding their behavior and decisions during an emergency evacuation. Computer simulations are focused on developing evacuation plans by minimizing the overall evacuation time, but fail to capture the dynamics, uncertainties, and complexities in a real-world evacuation scenario. Only few studies are devoted to measuring the accessibility of indoor environments to PWD, most of which are not suitable for wayfinding purposes. Finally, we discuss research gaps in developing indoor spatial models, accessible, personalized, and collaborative wayfinding, and real-time dynamic evacuation systems with accessible user-interfaces.
Risk Aversion and Planning Horizon

Number of empirical studies seem to reject the additive separability of preferences that is assumed in most theoretical models of the life cycle. We show that, when additive separability is abandoned, and interactions between consumptions at different dates are taken into account, an interesting relation emerges between risk aversion and length of planning horizon. Specifically, we show that when consumptions at different dates are specific substitutes, risk aversion increases with horizon length. This may explain the surprising empirical finding that individuals seem to increase the share of wealth held in risky assets as they become older.
Prevalence and antimicrobial susceptibility of Staphylococci isolated from the vagina of healthy ewes Prevalência e susceptibilidade aos antimicrobianos de Staphylococci isolados de vagina de ovelhas sadias

The aims of this study were identify the species of Staphylococcus sp. from the vagina of healthy ewes and determine their in vitro susceptibility to antibiotics. Sterile cotton swabs were used to collect samples from the vagina of 24 ewes. Standard bacteriological procedures were conducted. Coagulase-positive Staphylococcus species (COPS) represented 60% of the isolates and were significantly more resistant to antibiotics than coagulase-negative isolates. Resistance to antibiotics was frequently observed, and 66.6% of the isolates showed resistance to at least one tested drug. Ciprofloxacin was the most active antimicrobial agent (100%), while Penicillin G was the less effective (40% of resistance). This study confirms the presence of Staphylococcal isolates in the vagina of ewes, with predominance of CoPS isolates resistant to various antibiotics. This study contributes to a better knowledge about the role of Staphylococcus species in the ewe’s vagina and their antimicrobial susceptibility, collaborating for a better treatment of the vaginitis determined by these bacteria.
Ironing, Sweeping, and Multidimensional Screening

We provide existence proofs and characterization results for the multidimensional version of the multiproduct monopolist problem of Mussa and Rosen (1978). These results are also directly applicable to the multidimensional nonlinear pricing problems studied by Wilson (1993) and Armstrong (1996). We establish that bunching is robust in these multidimensional screening problems, even with very regular distributions of types. This comes from a strong conflict between participation constraints and second order incentive compatibility conditions. We consequently design a new technique, the sweeping procedure, for dealing with bunching in multidimensional contexts. This technique extends the ironing procedure of Mussa and Rosen (1978) to several dimensions. We illustrate it on two examples: we first solve a linear quadratic version of the bidimensional nonlinear pricing problem, where consumers' types are exponentially distributed. The solution involves pure bundling for consumers with low demands. The second example is the bidimensional version of the Mussa and Rosen problem when consumers' types are uniformly distributed on a square. The solution is such that the seller offers a full differentiation of products in the upper part of the qualities spectrum, but only limited choice for lower qualities. This seems to be a quite general pattern for multidimensional screening problems. The sweeping procedure is potentially applicable to other multidimensional screening problems.
Attosecond pulse generation from aligned molecules—dynamics and propagation in H2+

The dynamics and propagation effects in attosecond (asec) pulse generation from high-order harmonic generation (HHG) of aligned one-dimensional (1D) H2+ molecules are investigated from numerical solutions of fully coupled Maxwell and time-dependent Schrödinger equations (Maxwell-TDSEs), in the highly nonlinear nonperturbative regime of laser–molecule interaction. Density, laser-phase and propagation length effects are studied on the total electric field and nonlinear polarization from the Maxwell-TDSE for intense few cycle (800 nm) laser pulses interacting with a 1D H2+ gas. We show how single and double asec pulses can be generated and propagated as a function of the phase of individual harmonics created by ultrashort intense laser pulses in aligned H2+ molecules. We find furthermore extension of maximum HHG plateaux with increasing gas pressure.
Running title : Parasitoid dynamics during a psyllid outbreak

Insect herbivore outbreaks frequently occur and this may be due to factors that restrict top-down control by parasitoids, for example, host–parasitoid asynchrony, hyperparasitisation, resource limitation and climate. Few studies have examined host–parasitoid density relationships during an insect herbivore outbreak in a natural ecosystem with diverse parasitoids. We studied parasitisation patterns of Cardiaspina psyllids during an outbreak in a Eucalyptus woodland. First, we established the trophic roles of the parasitoids through a species-specific multiplex PCR approach on mummies from which parasitoids emerged. Then, we assessed host–parasitoid density relationships across three spatial scales (leaf, tree and site) over one year. We detected four endoparasitoid species of
A Cell-Penetrating Peptide Fused Phage Lysin Kills Intracellular MRSA 1 in Keratinocytes and Treatment for Skin Infections of Mice 2

14 Staphylococcus aureus (S. aureus) is the major pathogen that causes skin and skin 15 structure infections, which is able to survive and persist in keratinocytes of the 16 epidermis. Since the evolution of multi-drug resistant bacteria, the use of phages and 17 their lysins presents a promising alternative approach. In this study, a cell wall 18 hydrolase (also called lysin) derived from Staphylococcus phage JD007, short for 19 JDlys, was identified. The JDlys showed a strong lytic activity against MRSA strains 20 from different sources and multilocus sequence typing (MLST) types. Furthermore, a 21 fusion protein named CPPTat-JDlys, which consisted of a cell-penetrating peptide 22 (CPPTat) fused to JDlys, was used to kill intracellular methicillin-resistant S. aureus 23 (MRSA) infection. CPPTat-JDlys, which the fusion of CPPTat almost has not affected 24 the bacteriolytic activities of JDlys, was able to effectively eliminate intracellular 25 MRSA and alleviate the inflammatory response and cell damage caused by MRSA. 26 Specifically, CPPTat-JDlys was capable to combat MRSA-induced murine skin 27 infections and consequently expedite the healing of cutaneous abscesses. These data 28 suggested that the novel antimicrobial of CPP-JDlys may be a worthwhile candidate 29 to treat the skin and skin structure infections caused by MRSA. 30
Earth Pressure Distribution for Deep Excavations in Gravel Formations

There are no available guidelines for lateral earth pressure envelope in gravel formations, especially for high gravel content, ranged from 70 to 86%. Design of retaining structures and anchors in gravel is typically based on empirical experience and that was often too conservative. Therefore, this research collects twenty-five deep excavation cases in gravel deposits in Taichung areas. The value of apparent earth pressure had the tendency to increase as the depth of excavation increased. Comparison was made with the apparent earth pressure envelopes recommended by Peck (1969), Terzaghi and Peck (1967), and Tschebotarioff (1951). The acquired shape of the envelope was trapezoid and similar to the ones suggested by Terzaghi-Peck and Tschebotarioff. However, the value of the coefficient of apparent earth pressure was less than half of the values suggested by Terzaghi-Peck and Tschebotarioff. The distributions of apparent earth pressure at different excavation depths, 15, 20, and 27 m, could be obtained and normalized based on this study. The shape of the envelopes is similar to the one suggested by Tschebotarioff (1951), but the apparent earth pressure is much less.
Molecular Differences between DTFL and nodal FL 1 Duodenal type and nodal follicular lymphoma differ by their immune microenvironment rather than their mutation profiles Short title : Molecular Differences between DTFL and nodal FL

Robert-Bosch-Krankenhaus, Stuttgart, Germany; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology Stuttgart, and University of Tuebingen, Stuttgart, Germany; Dr. Senckenberg Institute of Pathology, University Hospital of Frankfurt, Frankfurt am Main, Germany; Princess Margaret Cancer Centre, Toronto, ON, Canada; Center for Cancer Genome Discovery, DanaFarber Cancer Institute, Boston, MA; University Hospital Muenster, Department of Medicine A, Blood First Edition Paper, prepublished online August 20, 2018; DOI 10.1182/blood-2018-03-837252
Shedding course of bovine respiratory syncytial virus and bovine parainfluenza 3 virus in calves vaccinated intranasally

Abstract Shedding time of bovine respiratory syncytial virus (BRSV) and bovine parainfluenza virus 3 (BPIV3) in calves vaccinated intranasally with modified live Rispoval RS-PI3 vaccine was determined. Blood and nasal swabs were collected on selected days before and after vaccination. Antibodies against BRSV and BPIV3 were tested by Respiratory ELISA Pentakit and the viral RNA was detected by RT-PCR. Twenty eight days after administration of the vaccine, a marked increase of specific antibody titres to BRSV and BPIV3 was detected in vaccinated calves. All animals were RT-PCR positive both for BRSV and BPIV3. Both viruses were excreted with nasal discharges within 8 d after vaccination but the course of shedding in individual calves was variable.
In Vitro Antioxidant and Anticancer Activities of Some Local Plants from Bolu Province of Turkey

Polyphenolic compounds of plant origin are of growing interest in cancer prevention and treatment especially because of their antioxidant potential contributing anticarcinogenic and antimutagenic effects. The diversity of Turkeys’ flora is remarkable for the development of new nutraceuticals or pharmaceuticals. In the present study, five local underutilized plant species: Kaldirik (Trachystemon orientalis), Sirken (Chenopodium album), Yagli Mancar (Rumex spp.1), Efelek (Rumex spp.2), Ebegumeci (Malva spp.) that are located in the Bolu Region of Turkey were investigated spectrophotometrically for total phenolic content and antioxidant capacity. Methanolic plant extracts were assessed for in vitro antioxidant activity by DPPH and CUPRAC assays. The cytotoxicity of plant extracts (100 to 1000 μg/mL) on MCT-7 cell lines were determined by MTT assay. The strongest antioxidant activities were shown for Rumex spp.1 and Rumex spp.2 with total phenolic contents of 26.71 and 16.17 mg Gallic acid equivalent/g dry weight (dw), respectively. Rumex spp.1 exhibited the highest total antioxidant capacity with 110.51 mg Trolox equivalent/g. Phenolic compound analysis done by Ultra-Fast Liquid Chromatography (UFLC) showed that both of the plants contain rutin, gallic acid, chlorogenic acid at most. The strongest cytotoxic activity was shown for Rumex spp.1 at highest concentration (1000 μg/mL) of these extracts with 56% cell viability.
Momentum Strategies and Karachi Stock Exchange

The objectives of this study is to investigate the momentum effect in Karachi stock exchange by taking the CAPM model as an assumption of investor’s momentum hypothesis. This study analyzed 16 momentum strategies based on partial rebalancing, Docile, and equal weighted techniques. The data of 83 companies listed at KSE-100 Index from 2007 to 2014 has used for analysis. The returns of winner portfolio were positive only in 1 out of 16 strategies while the returns of zero cost portfolios were positive in four out of 16 strategies. Moreover a diminishing trend in losses stated in 14 strategies has observed. Our analysis confirmed that loser portfolio is solitarily producing profit of our zero cost portfolios. We have also examined that weather returns have been earned due to Manager Performance or Systematic Risk. In all momentum strategies the value of beta and alpha confirmed that Return can be boosted by taking short position in loser’s portfolio with respect to winner portfolio and it also confirmed that there is no need to take more excessive risk. This study concluded that Winner and winner minus loser’s portfolio firms of KSE do not follow the momentum effect while loser’s portfolio firms of KSE follow the momentum effect. This study concluded and found low and significant momentum effect at Karachi stock exchange and these results are aligned with Mohsin (2012), Ji, Griffin and Martin (2003), Chui, and Rouwenhorst (1999). A further possibility of momentum shall exist in KSE if the sample increases and uses the daily data of listed company at KSE-100 index. Keywords: Karachi Stock Exchange, Momentum strategies, Momentum portfolio, Winner portfolio, Loser’s Portfolio, Zero cost portfolios, Systematic Risk.
The Relationship of Coping Responses and Metacognitive Beliefs with Addiction Potential in Male and Female Students, Behbahan University of Medical Sciences, Iran

This article aims to study the relationship of coping responses and metacognitive beliefs with addiction potential in male and female students studying in Behbahan University of Medical Sciences. Applying convenience sampling method, the sample size consisted of all students in Behbahan University of Medical Sciences. A correlational study was performed. Coping Response Inventory (CRI), Metacognitive Questionnaire (MCQ), and Addiction Potential Scale (APS) were administered to collect data. Pearson correlation coefficient and multivariate regression were employed to analyze the data. The results showed that coping responses are found to have a reverse and significant relationship with addiction potential. Metacognitive beliefs are found to have a reverse and significant relationship with addiction potential. Coping responses and metacognitive beliefs are found to have a reverse and significant relationship with addiction potential in students. No significant difference was found between male and female students in Behbahan University of Medical Sciences concerning coping responses, metacognitive beliefs, and addiction potential. According to above results, the effect of metacognitive beliefs is higher than coping responses. Significance level is a =0.05 in this study.
A nascent and modular repertoire of T 6 SS effectors

Secretion systems play a central role in infectious diseases by enabling pathogenic bacteria to deliver virulence factors into target cells. The type VI secretion system (T6SS) mediates bacterial antagonism in various environments including eukaryotic niches, such as the gut. This molecular machine injects lethal toxins directly in target bacterial cells. It provides an advantage to pathogens encountering the commensal flora of the host and indirectly contributes to colonization and persistence. Yet, the T6SS is not employed for the sole purpose of bacterial killing and several T6SS effectors are dedicated to the subversion of eukaryotic cells. As described for type III and type IV secretion systems, these effectors impede host cell functions and promote immune evasion, thereby enabling successful infection.
Bishop or Consequence ? Cerebral Asymmetry and Language Development : Cause , Correlate

, (2013); 340 Science Dorothy V. M. Bishop or Consequence? Cerebral Asymmetry and Language Development: Cause, Correlate, This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): June 1, 2014 www.sciencemag. org (this information is current as of The following resources related to this article are available online at http://www.sciencemag. org/content/340/6138/1230531.full. html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag. org/content/340/6138/1230531.full. html#ref-list-1 , 21 of which can be accessed free: cites 84 articles This article http://www.sciencemag. org/content/340/6138/1230531.full. html#related-urls 1 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag. org/cgi/collection/neuroscience Neuroscience subject collections: This article appears in the following