Miracle-dz/UniFAR-FTUs huggingface dataset:
Bilateral jaw fracture after long term treatment with bisphosphonates. A case report.

espanolLos bifosfonatos son farmacos ampliamente utilizados en el tratamiento de numerosas enfermedades. Diferentes profesionales utilizan los bifosfonatos para tratar complicaciones de patologias oncologicas, osteoporosis y patologias reumatologicas. Sin embargo, a pesar de los efectos beneficos, existen efectos secundarios consecuente al utilizo de este tipo de medicamento. Por ejemplo, la osteonecrosis maxilar es mas frecuente en pacientes tratados con bifosfonatos. En este sentido, la posibilidad de desarrollar osteonecrosis maxilar es del 0,812% cuando la medicacion es administrada por via intravenosa y del 0,01% en caso de administracion oral. Ademas, cuando se realiza una extraccion dental el riesgo incrementa de un 0,34%. Este articulo presenta el caso de una paciente de 66 anos que sufrio una fractura bilateral y espontanea de la mandibula tras el utilizo de bifosfonatos durante un largo periodo de tiempo. Es importante enfatizar que, en este caso, el paciente no habia sido sometido a intervenciones de cirugia oral en los meses previos. El principal objetivo de este estudio es focalizar la atencion sobre las posibles complicaciones provocadas por este medicamento. EnglishBisphosphonates represent type of medication used for treating numerous pathologies. In fact, more and more clinicians utilize bisphosphonates for dealing oncological diseases, rheumatic pathologies and severe osteoporosis. Despite its benefits, various undesirable side effects have also been associated with the use of these drugs. For instance, patients who receive bisphosphonates present a greater risk of suffering osteonecrosis of jaw. Indeed, the possibility of experiencing this complication is around 0,812% when bisphosphonates are administered intravenously. In contrast, the risk is about 0,01% with oral administration. However, when a tooth extraction is carried out the risk rises to 0,34%. This report presents the case of a 66 years old woman who suffered a bilateral jaw fracture after prolonged treatment with bisphosphonates. Interestingly, no invasive dental procedures were referred by patient. The main aim of this paper is to focus the attention on the serious complications that this treatment may show in the long term.
The Community Earth System Model Version 2 (CESM2)

An overview of the Community Earth System Model Version 2 (CESM2) is provided, including a discussion of the challenges encountered during its development and how they were addressed. In addition, an evaluation of a pair of CESM2 long preindustrial control and historical ensemble simulations is presented. These simulations were performed using the nominal 1° horizontal resolution configuration of the coupled model with both the “low‐top” (40 km, with limited chemistry) and “high‐top” (130 km, with comprehensive chemistry) versions of the atmospheric component. CESM2 contains many substantial science and infrastructure improvements and new capabilities since its previous major release, CESM1, resulting in improved historical simulations in comparison to CESM1 and available observations. These include major reductions in low‐latitude precipitation and shortwave cloud forcing biases; better representation of the Madden‐Julian Oscillation; better El Niño‐Southern Oscillation‐related teleconnections; and a global land carbon accumulation trend that agrees well with observationally based estimates. Most tropospheric and surface features of the low‐ and high‐top simulations are very similar to each other, so these improvements are present in both configurations. CESM2 has an equilibrium climate sensitivity of 5.1–5.3 °C, larger than in CESM1, primarily due to a combination of relatively small changes to cloud microphysics and boundary layer parameters. In contrast, CESM2's transient climate response of 1.9–2.0 °C is comparable to that of CESM1. The model outputs from these and many other simulations are available to the research community, and they represent CESM2's contributions to the Coupled Model Intercomparison Project Phase 6.
A Network Flow Based Energy-Efficient Backhauling Algorithm for mm-Wave Small Cell Networks

The millimeter wave small cell backhaul network is one of the key solutions in 5G small cell backhaul. However, a lot of new challenges will be faced the multi-hop path planning is designed. In this paper, a flow network based energy efficient backhaul path planning algorithm (FBPA) is proposed for highly dense millimeter wave small cell networks so that the backhaul path planning with maximum throughput as well as minimum energy consumption is obtained. Firstly, the backhaul path planning problem is modelled as an integer programming (IP) problem, which is always a NP -hard problem. Then, a liner relaxation technique is used to make the problem be easier to resolve. Finally, the FBPA algorithm is proposed to find the path planning with minimum cost and maximum flow. Extensive simulations are conducted, the simulation results show that the backhaul throughput is improved by about 66.7% and energy efficiency is decreased by nearly 10% when the FBPA is compared to the existing path planning algorithm.
Intérêt de l'utilisation des facteurs plaquettaires (PRF) dans les comblements sous-sinusiens : revue systématique de la littérature

Le sinus lift est une methode chirurgicale qui permet d'elever le plancher sinusal et ainsi augmenter la hauteur de l'os maxillaire posterieur. Les sinus lift utilisent generalement une xenogreffe comme materiau de comblement. Le PRF (Platelet-Rich Fibrin) est obtenu a partir d'une prise de sang directement au cabinet et permet d'avoir rapidement une matrice cicatricielle permettant la regeneration rapide d'un os. L'utilisation des facteurs plaquettaires dans les sinus lift en materiau de comblement seul ou combine a une xenogreffe de type bio os comme materiau de regeneration a ete etudie grâce a une revue systematique de la litterature. Sur un total de 115 articles potentiels seulement 13 articles ont ete selectionnes dont 6 articles etudiant du PRF seul, 6 articles avec du PRF en complement de Bio-oss® et un article comparant le PRF seul et une allogreffe L'etude approfondie de ces articles a permis de conclure que l'utilisation seule du PRF comme materiau de comblement ne peut confirmer son avantage par rapport aux autres techniques de sinus lift du fait d'un trop petit nombre d'etudes avec peu d'echantillon et avec un niveau scientifique faible. De meme l'utilisation du PRF combine a un Bio-oss® ne permettrait pas un gain de temps de cicatrisation significatif. Le faible niveau de preuve scientifique de ces etudes ne justifie pas l'apport de PRF dans les xenogreffes. L'utilisation du PRF dans le cadre des sinus lifts n'est pas encore justifiee en pratique quotidienne. De nombreuses preuves scientifiques sont encore necessaires pour prouver son efficacite.
The Ocular Glymphatic Clearance System

Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified a novel ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve. Amyloid-β (Aβ) was cleared from the vitreous via a pathway driven by the ocular-cranial pressure difference. After traversing the lamina barrier, intra-axonal Aβ was cleared via the perivenous space and subsequently drained to lymphatic vessels. Light-induced pupil constriction enhanced, while atropine or raising intracranial pressure blocked efflux. In two distinct murine models of glaucoma, Aβ leaked from the eye via defects in the lamina barrier instead of directional axonal efflux. The discovery of a novel pathway for removal of fluid and metabolites from the intraocular space prompts a reevaluation of the core principles governing eye physiology and provides a framework for new therapeutic approaches to treat common eye diseases, including glaucoma. One Sentence Summary Glymphatic pathway clears ocular amyloid-β via optic nerve and fails in glaucoma.
Combinatorial action of transcription factors in open chromatin contributes to early cellular heterogeneity and organizer mesendoderm specification

During gastrulation, mesoderm is induced in pluripotent cells, concomitant with dorsal-ventral patterning and establishing of the dorsal axis. How transcription factors operate within the constraints of chromatin accessibility to mediate these processes is not well-understood. We applied chromatin accessibility and single cell transcriptome analyses to explore the emergence of heterogeneity and underlying gene-regulatory mechanisms during early gastrulation in Xenopus. ATAC-sequencing of pluripotent animal cap cells revealed a state of open chromatin of transcriptionally inactive lineage-restricted genes, whereas chromatin accessibility in dorsal marginal zone cells more closely reflected the transcriptional activity of genes. We characterized single cell trajectories in animal cap and dorsal marginal zone in early gastrula embryos, and inferred the activity of transcription factors in single cell clusters by integrating chromatin accessibility and single cell RNA-sequencing. We tested the activity of organizer-expressed transcription factors in mesoderm-competent animal cap cells and found combinatorial effects of these factors on organizer gene expression. In particular the combination of Foxb1 and Eomes induced a gene expression profile that mimicked those observed in head and trunk organizer single cell clusters. In addition, genes induced by Eomes, Otx2 or the Irx3-Otx2 combination, were enriched for promoters with maternally regulated H3K4me3 modifications, whereas promoters selectively induced by Lhx8 were marked more frequently by zygotically controlled H3K4me3. Our results show that combinatorial activity of zygotically expressed transcription factors acts on maternally-regulated accessible chromatin to induce organizer gene expression.
A case of spontaneous subarachnoid hemorrhage and intraventricular hemorrhage with negative computed tomography angiography findings

Brain computed tomography angiography (CTA) is a useful tool for detecting subarachnoid hemorrhage (SAH) and cerebral aneurysms, but less reliably when cerebral aneurysms which are smaller than 2 mm. We present a case of spontaneous SAH and intraventricular hemorrhage (IVH) with negative findings on brain CTA. Due to the clinical presentation and positive neurologic examination, lumbar puncture was performed and xanthochromia of cerebrospinal fluid (CSF) had been noted. Cerebral angiography was performed and showed a small unruptured saccular cerebral aneurysm (<2 mm).
Efecto modulador ex vivo de los fármacos biológicospara la enfermedad inflamatoria intestinal sobre lascélulas mononucleares de sangre periférica y lamucosa intestinal

Inflammatory bowel disease comprises a group of chronic disorders of the gastrointestinal tract mainly classified into Crohn's disease and ulcerative colitis. It is a serious condition that affects millions of people worldwide and which precise etiology remains unknown. Despite the variety of pharmacological treatments available, such us the new biological drugs, there is no effective treatment to cure this pathology and the current goal is to induce and maintain remission to improve the quality of life of these patients. Biological drugs can act on different targets that have a key role in the disease, however their mechanisms of action are partly understood. This work aims to evaluate the ex vivo modulatory effect of biological drugs with different targets –infliximab, inflectra and adalimumab (anti-TNF-α), and vedolizumab (antiintegrin α4β7)– on the migration of peripheral blood mononuclear cells (PBMCs) to the intestinal mucosa in healthy patients. To this end, PBMCs were obtained and cultured in the absence/presence of biological drugs. Afterwards, migratory surface markers (beta7, CCR2, CCR5, CCR6 and CCR9) of the subpopulations of antigen presenting cells (APCs) were characterized by flow cytometry, as well as their capacity to migrate towards different intestinal chemoattractants (CCL2, CCL25 and MAdCAM1) on a transwell culture model. This study demonstrates the blockade that vedolizumab exerts on integrin α4β7, reducing the expression of beta7 on the surface of APCs. In contrast, anti-TNF-α drugs seem to increase the expression of this integrin in monocytes. Functional assays on transwell model show that ligand CCL2 induces the most potent effect over the spontaneous migration of APCs. Moreover, after culture with biological drugs, this study suggests that the ex vivo modulatory effect of biological drugs over the recruitment of APCs might be preferentially mediated through ligand CCL2. This work highlights the role of biological drugs over the migratory capacity of circulating APCs towards the intestinal mucosa in healthy individuals, setting the basis to further explore this mechanism of action in inflammatory bowel disease patients.
Family Structure and Literacy Level as Correlates of Post-traumatic Stress among Victims of Human Trafficking in Nigeria

Victims of human trafficking suffer a plethora of psychological problems and it has been one of much deliberation by governments and other human rights organizations. Thepresent study examined the family structure and literacy levels as predictors of Post-Traumatic stress among a group of selected victims of human trafficking. A cross-sectional survey design was adopted in the study. Accidental sampling technique was performed to select seventy-eight (78) victims of human trafficking who were in different zones of the National Agency for Trafficked Persons (NAPTIP). Post-traumatic Stress Scale, developed by Keane et al (1984) was used to gather necessary information for the study with Cronbach’s Alpha of . 92. Three hypotheses were formulated as well as tested by using Pearson Product Moment Correlation and independent t-test analysis. The results showed that literacy level, [r (78) = . 24; p > 0.05] and family structure [r (78) = . 31; p > 0.01] were significantly correlates with Post-Traumatic Stress. Based on the findings, it is recommended Original Research Article Okeke and Ogbonnaya; AJMAH, 17(1): 1-11, 2019; Article no.AJMAH. 52427 2 that National Agency for Trafficked Persons should engage victims into therapeutic and educational programmes and using clinical interventions to help boost self-esteem, self-awareness and psycho-emotional development of these victims to reduce trauma-related problems associated with activities of human trafficking.
Quantitative impacts of mandatory integrated reporting

This paper aims to examine the impact of the 2011 mandatory introduction of integrated reporting ( ) on the financial performance, risk and institutional shareholding of listed companies in South Africa to assess whether there is a benefit to and which may encourage greater adoption of it globally. It contrasts the results with two other African stock exchanges (Nigeria and Egypt with no mandatory ) and examines whether quality also has an impact on these and on environmental, social and governance (ESG) disclosure scores. ,A series of multivariate ordinary least squares regressions was estimated on a range of financial, risk, institutional and ESG data from firms on the three African stock exchanges, between 2006 and 2015. ,Financial performance and risk in South African firms appear to have decreased since the start of mandatory reporting, but institutional shareholding has increased. The production of higher quality reports is associated with decreased financial performance and risk, higher institutional shareholding and increased ESG scores. ,This study is first to test the quantitative effects of and quality on a broad range of financial performance and risk measures and the level of institutional shareholding. It also adds to the literature by assessing how the quality of can impact the ESG scoring of the business. Hence, this study is of interest to firms looking to adopt for its benefits and to regulatory bodies considering the mandatory adoption of in support of achievement of national social and environmental goals.
Vapour pressures, evaporation behaviour and airborne concentrations of hazardous drugs: implications for occupational safety

Dr Kiffmeyer is head of the environmentalmedicine working group, Dr Kube is head of theanalytical laboratory, Dr Opiolka is projectmanager in the department of chemicalengineering, Professor Schmidt is head of thedepartment of chemical engineering and scientificmanager of the institute, and Mr Schoppe isbusiness manager at the Institute of Energy andEnvironmental Technology, Duisburg, Germany.Dr Sessnick is owner of the consultancy practiceExposure Control in Wijchen, the Netherlands.Correspondence to Dr Kiffmeyer, Institute ofEnergy and Environmental Technology,Bliersheimer Strasse 60, D-47229 Duisburg,Germany
A Multicenter Phase II Study Using a Dose Intensified Pediatric Regimen in Adults with Untreated Acute Lymphoblastic Leukemia.

Background: In children with ALL, current chemotherapy regimens produce an event-free survival (EFS) of greater than 80%. Adults with ALL have a much poorer prognosis, with EFS rates of 30–40%. Recent retrospective studies suggest that young adult patients may have superior outcomes when treated on more intensive pediatric regimens, but prospective studies are lacking. A phase II trial was performed in an effort to determine if an intensive pediatric regimen can be administered to adults with ALL. Methods: The therapeutic backbone of this protocol is based upon the high-risk arm of the DFCI Childhood ALL Consortium Protocol 00–01. Patients with newly diagnosed ALL were enrolled and received intensive multiagent remission induction chemotherapy, which included doxorubicin, prednisone, vincristine, high-dose methotrexate, high-dose asparaginase, and triple intrathecal therapy. CNS prophylaxis included triple intrathecal therapy and cranial radiation. Intensification therapy consisted of 3 week courses of doxorubicin, vincristine, dexamethasone, 6-mercaptopurine and 30 weeks of high-dose asparaginase that was individually dosed in order to maintain asparagine depletion. Continuation therapy consisted of 3 week courses of vincristine, dexamethasone, methotrexate and 6-mercaptopurine for a total of 2 years from an established complete remission (CR). Results: 71 patients have been enrolled to date. Although there was no initial upper age restriction, the protocol was amended to include only patients between the ages of 18–50 with de novo ALL; this amendment excluded 4 patients from the analysis. Two patients were enrolled but never received therapy. Demographic data are available for 61 evaluable patients. The median age was 28 years, (range, 18–50), 65% were male, 75% had B-lineage phenotype, and 13% were Philadelphia chromosome positive. In the 54 patients for whom response data was available, the 4 week CR rate was 82%. Among the patients who had the opportunity to complete Intensification therapy, asparaginase data was available for 23 patients, 18 (78%) of whom completed all 30 weeks. One death occurred during induction therapy from sepsis. Four patients developed grade 3 pancreatitis and one patient died of grade 5 pancreatitis. The latter case represented the only remission death on study. There were two cases of osteonecrosis, 10 cases of thrombosis/embolism and 12 cases of neutropenic infection that occurred during the post-remission period. At the median follow-up time of 18.4 months, the estimated EFS is 75% (95%CI: 61–89%) and the overall survival is 79% (95%CI: 65–93%). Conclusions: These results suggest that administration of a dose intensified pediatric-like strategy is feasible. Although the high EFS rate requires longer follow up and larger confirmatory studies, such intensive treatment of young adults with ALL could represent a major therapeutic advance.
A PRIORIDADE DE UMA ONTOLOGIA FUNDAMENTAL DO SER-MÉDICO: UMA CONTRIBUIÇÃO PARA ÉTICA MÉDICA

Este artigo tem como objetivo discutir o sentido ( Sinn ) da ocupacao medica. Atraves de uma estrutura de abordagem baseada na ontologia fundamental de Martin Heidegger, procuramos estabelecer os criterios para uma justa apropriacao do sentido da ocupacao medica, bem como contribuir para o campo da Bioetica, enquanto disciplina, instaurando uma nova perspectiva para a Etica medica. Entendemos que a Bioetica se assenta sobre uma determinada interpretacao do ente, inteiramente herdeira da metafisica da Modernidade e que este entendimento amputado da experiencia humana tem suas consequencias para a etica medica. Isto posto, convidamos o leitor a um pensar que seja capaz de considerar a praxis do medico de um modo mais integral, a proposta de um novo paradigma para se acessar e se pensar as indagacoes da Bioetica sobre o ser-medico .
Post-radiational ureteric fibrosis with extrarenal renal failure as a rare complication after adjuvant treatment of gastric cancer - a case report

Dotychczas nie ustalono zasad leczenia skojarzonego u chorych na raka zolądka. W wielu ośrodkach u chorych, u ktorych stwierdza sie niekorzystne czynniki rokownicze, po radykalnej gastrektomii stosuje sie schemat Macdonalda polegający na skojarzeniu napromieniania i podawania fluorouracylu. Statystycznie u ponad 30% pacjentow poddanych chemioradioterapii wystepują powazne powiklania. W niniejszej pracy przedstawiono przypadek chorego, u ktorego wystąpilo zwloknienie moczowodow z nastepową niewydolnością nerek po zastosowaniu schematu Macdonalda w leczeniu uzupelniającym raka zolądka. Jest to powiklanie rzadkie, mogące stanowic zagrozenie zycia chorego. Stan sprawności chorego mimo jego zaawansowanego wieku i wspolistniejących chorob byl bardzo dobry. Z powodu niekorzystnych czynnikow prognostycznych u pacjenta zastosowano chemioterapie. Na podstawie tego przypadku mozna wnioskowac, ze kwalifikacje do takiego leczenia nalezy przeprowadzac szczegolnie ostroznie. W pracy przedstawiono rowniez inne metody leczenia uzupelniającego u chorych na raka zolądka.
Global analysis of a multi-group viral infection model with age structure

ABSTRACT In this paper, we consider a multi-group viral infection model with age structure and general incidence. We first give the positivity and boundedness of the solutions. Then, we study the local stability of the equilibria and uniform persistence of this model. Moreover, we establish the global results by constructing Lyapunov functionals. Finally, two special cases are presented to verify the validity of our theoretical results.