Miracle-dz/UniFAR-FTUs huggingface dataset:
Embedded control system development using UML for automatic doors

In this paper, we propose a design pattern with the unified modeling language (UML) for the automatic door control system development, and we define a UML class diagram to describe structural aspect of system, and we also define a set of sequence diagrams to specify behavior of system. The UML is a new industrial standard for the software system modeling. It is a graphical language with “Taxi Display” to express the aspects of system construction, and the UML has been presented in software system development widely. Generally, the automatic door system is one kind of systems which are widely used in modern buildings. The automatic door system is an embedded control system that includes three components, such as the motor, the sensor, and the controller.
High-dose regimen of interleukin-2 and interferon-alpha in combination with lymphokine-activated killer cells in patients with metastatic renal cell cancer.

Seventy-two patients with metastatic renal cell cancer were treated with the combination of high-dose interleukin-2 (IL2), interferon-alpha (IFN alpha), and lymphokine-activated killer cells (LAK). Seventeen patients were entered in a feasibility part of the study (protocol 1) and 55 in an efficacy part (protocol 2). Protocol 2 differed from protocol 1 in the addition of IFN alpha to the first 5 days of IL2 infusion. Each patient was planned to receive two induction cycles. IL2, 18 MIU/m2/day, was administered continuously i.v. on days 1-5, and IFN alpha, 5 MIU/m2/day (protocol 2), was administered i.m. on days 1-5, followed by three daily lymphaphereses on days 7-9. On day 12, treatment was resumed with IL2 and IFN alpha on days 12-15 and LAK reinfusions on days 12-14. In protocol 1, three complete (CR) and one partial (PR) responses were achieved (response rate 24%). The median duration of response and the median survival were 18.1 and 13.9 months, respectively. The 3-year survival was 35%. Of the 51 evaluable patients in protocol 2, 6 achieved a CR and 13 a PR (response rate 37%). The median duration of response was 11.1 months. The median survival was 16.9 months. The 3-year survival was 35%. There were three treatment-related deaths. Other severe toxicities included hypotension, cardiotoxicity, pulmonary edema, renal toxicity, and infectious complications. In the two induction cycles, only 54 and 42% of the planned doses could be administered. We conclude that the use of high-dose regimens of IL2 and IFN alpha is not warranted, unless we can define more accurately which patients may experience long-term survival as a result of treatment.
Control of the necrosed tissue volume during noninvasive ultrasound surgery using a 16-element phased array.

Focused high-power ultrasound beams are well suited for noninvasive local destruction of deep target volumes. In order to avoid cavitation and to utilize only thermal tissue damage, high frequencies (1-5 MHz) are used in ultrasonic surgery. However, the focal spots generated by sharply focused transducers become so small that only small tumors can be treated in a reasonable time. Phased array ultrasound transducers can be employed to electronically scan a focal spot or to produce multiple foci in the desired region to increase the treated volume. In this article, theoretical and experimental studies of spherically curved square-element phased arrays for use in ultrasonic surgery were performed. The simulation results were compared with experimental results from a 16-element array. It was shown that the phased array could control the necrosed tissue volume by using closely spaced multiple foci. The phased array can also be used to enlarge a necrosed tissue volume in only one direction at a time, i.e., lateral or longitudinal. The spherically curved 16 square-element phased array can produce useful results by varying the phase and amplitude setting. Four focal points can be easily generated with a distance of two or four wavelengths between the two closest peaks. The maximum necrosed tissue volume generated by the array can be up to sixteen times the volume induced by a similar spherical transducer. Therefore the treatment time could be reduced compared with single transducer treatment.
Identification of mammary carcinogens in rodent bioassays

Results from chemical carcinogenesis studies in rodents are useful to identify substances in our environment that may contribute to cancer development. The National Toxicology Program (NTP) was established in 1978 to coordinate research and testing of potential human carcinogens and to publish the Report on Carcinogens, which lists human carcinogens. The results for over 500 chemicals tested in the NTP 2‐year bioassays have been published in Technical Reports and include data for chemical, agent, or complex mixture exposures. The bioassays have identified 42 chemicals that induce tumors in the rodent mammary gland. The physical and chemical characteristics of the carcinogens vary, but epoxides (including chemicals metabolized to epoxides) and nitro‐containing compounds are well represented. The 9th Report on Carcinogens, issued in 2000, lists 21 of the 42 chemicals as human carcinogens including benzene, ethylene oxide, 1,3‐butadiene, isoprene, chloroprene, C.I. basic red 9, and C.I. acid red 114. Ethylene oxide was associated with increased breast cancer risk in an epidemiologic study, whereas other listed chemicals, for which human data are available, display different target organ specificity. Bioassays other than those conducted by the NTP also provide information about rodent mammary gland carcinogens. Several carcinogen exposures are associated with breast tumor induction in both humans and rodents including radiation, diethylstilbestrol, and estrogens. These studies demonstrate that route, timing and frequency of exposure, and genetic factors contribute to the overall susceptibility to breast cancer development. More information is needed on the effects of chemicals to which humans are exposed and the manner by which they influence breast cancer risks. Environ. Mol. Mutagen. 39:150–157, 2002. Published 2002 Wiley‐Liss, Inc.
Developing an E-textbook for the Consumer and Family Sciences Class: Challenges and Rewards

This report describes the self-publishing journey, challenges and methods of development, impact, the value of a self-published e-textbook in tenure decisions, and recommendations. This journey lead to the self-publishing of an e-textbook for iPad® delivery at a Midwest university 2 for a course on electronic distribution and hotel management in the Consumer and Family Sciences curriculum. Factors leading to this decision included the context of the digital hospitality world, industry standards, technology use by students, lack of interest by major publishers, e-textbook and iPad learning research, and iPad technical and training support available to a cohort of faculty on campus.
The Balanced Scorecard System as a Performance Measurement Tool for Public Sector Organisations: The Case of the Media Information Communications Technology Sector Education Training Authority (MICT-SETA), Republic of South Africa

This work focuses on enriching the already available theory concerning public sector management. Experiential validation of employing the Balanced Scorecard for the public sector organisations is examined. An interpretive paradigm in combination with an action research strategy was employed in carrying out the study. The data were collected using both focus group discussions and personal interviews. The analysis was through content and interpretation examination. It is assumed that this study, having focused on one authority whose function is to enhance skills development within the information and communications technology sector in South Africa. The results in this work indicate Original Research Article Mopaki and Mutono; BJAST, 18(1): 1-9, 2016; Article no.BJAST. 29531 2 that public organisations should endeavour to put people they serve (clients) at the forefront of their strategic plans. This result confirms the results reported by Kaplan and Norton [9]. Still the study findings indicated that bodies that fund public organisations should as well be taken as stakeholders in the organisational strategic plan, and require to be satisfied in order to ensure continuity of funding. Departmental balanced scorecards should be embraced in contrast to an entire organisational balanced scorecard which seems to be a suggestion from some researchers and scholars. The core advantage with this is that it enhances corporation as opposed to individualism and leads to cohesion rather than divisions.
PDK1 Recruitment to the SHPS-1 Signaling Complex Enhances Insulin-like Growth Factor-I-stimulated AKT Activation and Vascular Smooth Muscle Cell Survival*

In vascular smooth muscle cells, exposed to hyperglycemia and insulin-like growth factor-I (IGF-I), SHPS-1 functions as a scaffold protein, and a signaling complex is assembled that leads to AKT activation. However, the underlying mechanism by which formation of this complex activates the kinase that phosphorylates AKT (Thr308) is unknown. Therefore, we investigated the mechanism of PDK1 recruitment to the SHPS-1 signaling complex and the consequences of disrupting PDK1 recruitment for downstream signaling. Our results show that following IGF-I stimulation, PDK1 is recruited to SHPS-1, and its recruitment is mediated by Grb2, which associates with SHPS-1 via its interaction with Pyk2, a component of the SHPS-1-associated complex. A proline-rich sequence in PDK1 bound to an Src homology 3 domain in Grb2 in response to IGF-I. Disruption of Grb2-PDK1 by expression of either a Grb2 Src homology 3 domain or a PDK1 proline to alanine mutant inhibited PDK1 recruitment to SHPS-1, leading to impaired IGF-I-stimulated AKT Thr308 phosphorylation. Following its recruitment to SHPS-1, PDK1 was further activated via Tyr373/376 phosphorylation, and this was required for a maximal increase in PDK1 kinase activity and AKT-mediated FOXO3a Thr32 phosphorylation. PDK1 recruitment was also required for IGF-I to prevent apoptosis that occurred in response to hyperglycemia. Assembly of the Grb2-PDK1 complex on SHPS-1 was specific for IGF-I signaling because inhibiting PDK1 recruitment to SHPS-1 had no effect on EGF-stimulated AKT Thr308 phosphorylation. These findings reveal a novel mechanism for recruitment of PDK1 to the SHPS-1 signaling complex, which is required for IGF-I-stimulated AKT Thr308 phosphorylation and inhibition of apoptosis.
Providing Learning Incentives and the Use of a Multi-Purpose Performance Measure

This paper analyses the role of leading indicators that provide a firm manager with learning incentives of firm-specific skills. The effectiveness of leading indicators varies with contract scheme hired between the firm owner and the firm manager. I show that the leading indicator complements the outcome’s role of incentive provision at the sacrifice of information rent caused by the information asymmetry regarding manager’s learning capacity.
The relationship between corporate governance and ownership structures of firms listed at the Nairobi stock exchange

vi LIST OF FIGURES . vii LIST OF TABLES . viii CHAPTER ONE :INTRODUCTION . 1 1.1 Background to the Study . 1 1.1.1 Corporate Governance Structures . 3 1.1.2 Ownership Structures . 4 1.1.3 Nairobi Stock Exchange . 4 1.2 Statement of the Problem . 5 1.3 Objective of the Study . 6 1.4 Importance of the Study . 7 CHAPTER TWO: LITERATURE REVIEW . 8 2.
Bruxisma related to levodopa therapy.

To the Editor. — During the investigation phase of levodopa (L-Dopa) therapy for Parkinson's disease, clinicians have reported a wide range of side effects. Fortunately most are not serious; however, several are difficult to control without nullifying the dose or the effectiveness of the drug. In many instances, such as the case reported here, the physician faces the challenge of detecting and managing side effects. The abnormal involuntary movements that result from levodopa therapy frequently appear in the face, lips, and tongue and are often termed "mouthing" movements. Movements of the extremities may resemble chorea or athetosis. Forced hyperventilation, neck jerking, or slow arm or leg movements that are not actually choreal or athetosic still do not fit into other common classifications of abnormal movements. These signs are a limiting factor in dosage, and as they develop, the physician must weigh their severity against the patient's relief from the symptoms of
in Firms, Contracts, and Other Governance Structures

This paper explores how governance structures (defined as ex ante allocations of decision rights and payoff rights) affect how parties adapt to changing circumstances. Our model allows for an arbitrary number of parties and an arbitrary number of decision rights, payoff rights, and assets (inseparable bundles of decision rights and payoff rights). We solve for the governance structure that maximizes expected social surplus under spot adaptation, and also for the (typically different) governance structure that maximizes surplus under relational adaptation. We offer three complementary interpretations of our model: a theory of the firm without specific investments; a theory of decision rights allocated between firms via contract; and a theory of alternative governance structures such as alliances, networks, and joint ventures.
Photodynamic Studies of Metallo 5,10,15,20‐Tetrakis(4‐methoxyphenyl) porphyrin: Photochemical Characterization and Biological Consequences in a Human Carcinoma Cell Line ¶

The photodynamic activities of the free‐base 5,10,15,20‐tetrakis(4‐methoxyphenyl)porphyrin (TMP) and their metal complexes with zinc(II) (ZnTMP), copper(II) (CuTMP) and cadmium(II) (CdTMP) have been compared in two systems: reverse micelle of n‐heptane/sodium bis(2‐ethylhexyl)sulfosuccinate/water bearing photooxidizable substrates and Hep‐2 human larynx carcinoma cell line. The quantum yields of singlet molecular oxygen, O2(1Δg), production (ΦΔ) of TMP, ZnTMP and CdTMP in tetrahydrofuran, were determined yielding values of 0.65, 0.73 and 0.73, respectively, while O2(1Δg) formation was not detected for CuTMP. In the reverse micellar system, the amino acid l‐tryptophan (Trp) was used as biological substrate to analyze the O2(1Δg)‐mediated photooxidation. The observed rate constants for Trp photooxidation (kobsTrp) were proportional to the sensitizer quantum yield of O2(1Δg). A value of ∼2 × 107 s−1M−1 was found for the second‐order rate constant of Trp (krTry) in this system. The response of Hep‐2 cells to cytotoxicity photoinduced by these agents in a biological medium was studied. The Hep‐2 cultures were treated with 1 μM of porphyrin for 24 h at 37°C and the cells exposed to visible light. The cell survival at different light exposure levels was dependent on ΦΔ. Under these conditions, the cytotoxic effect increases in the order: CuTMP ≪ TMP < ZnTMP ∼ CdTMP, correlating with the production of O2(1Δg). A similar behavior was observed in both the chemical and biological media indicating that the O2(1Δg) mediation appears to be mainly responsible for the cell inactivation.
Crosstalk between Hippo signalling and miRNAs in tumour progression

The Hippo signalling pathway co‐ordinately modulates cell regeneration and organ size, and its deregulation contributes to tumorigenesis through many cellular processes, including overproliferation, apoptosis resistance and cell migration. Recent discoveries have shed new light on how microRNAs (miRNAs) are closely linked to the Hippo pathway in tumour progression. Hippo signalling has been reported to affect widespread miRNA biogenesis. In turn, several miRNAs regulate Hippo signalling, which contributes to carcinogenesis. This article will provide an overview of the crosstalk between Hippo signalling and miRNAs in the development of cancer and further appraise potential targets for therapeutic intervention.
Ketorolac Use for Postoperative Pain Management Following Lumbar Decompression Surgery: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial

Study Design. Prospective randomized double-blind placebo-controlled study. Objective. The objective of this study was to assess the efficacy of Ketorolac in reducing postoperative pain and morphine requirements following primary multilevel lumbar decompression surgery. Summary of Background Data. The use of opioid medications following surgical interventions can be complicated by related side effects such as respiratory depression, somnolence, urinary retention, and delayed time to oral intake. The use of Ketorolac, a potent nonopioid, nonsteroidal anti-inflammatory drug, is an attractive alternative to morphine as many of the opioid-related side effects can be avoided. Methods. After Institutional Review Board approval, 25 patients who underwent a primary multilevel lumbar decompression procedure were randomly assigned to receive either Ketorolac or placebo in a double-blinded fashion. After surgery, all patients were allowed to receive intravenous morphine on an as needed basis. Morphine requirements were then recorded immediately postoperative, at 6, 12, and at 24 hours postoperative. A patient’s overall hospital course morphine requirement was also assessed. Patient postoperative pain levels were determined using the Visual Analog Pain Scale and were documented at 4, 8, 12, 16, 24, and 36 hours postoperative. Results. There were no significant differences in available patient demographics, intraoperative blood loss, or postoperative Hemovac drain output between study groups. Morphine equivalent requirements were significantly less at all predetermined time points in addition to the overall hospital morphine requirement in patients randomized to receive Ketorolac. Visual Analog Pain Scores were significantly lower in patients randomized to receive Ketorolac immediately postoperative in addition to 4, 12, and 16 hours postoperative. There were no identifiable postoperative complications associated with the use of Ketorolac. Conclusion. Intravenous Ketorolac seems to be a safe and effective analgesic agent following multilevel lumbar decompressive laminectomy. Patients can expect lowermorphine requirements and better pain scores throughout their postoperative course.
Can Codes of Conduct Work? Evaluating the Effectiveness of Privatised Corporate Governance

Over the last couple of decades, the world has witnessed a spectacular increase in the size and number of Transnational Corporations (TNCs). This explosion has resulted in the overseas practices of such companies coming under intense scrutiny, and has highlighted that in most cases, governments lack the resources necessary to ensure TNC compliance to international standards in key areas such as labour rights, environmental pollution, and social justice. As a direct result of the failure of national and international attempts to regulate corporate behaviour, recent years have seen the mushrooming of a number of codes aimed at regulating corporate behaviour, and an increased focus on corporate social responsibility. This chapter will attempt to evaluate the effectiveness of such codes of ethical corporate conduct in the light of available evidence, focusing on the conceptualisation of such regulatory mechanisms, and their relationship to the larger corpus of corporate social, commercial, and ethical interactions. The work will then seek to evaluate the effectiveness of such codes as instruments of privatised governance, particularly through the examination of corporate stakeholder behaviour and recent examples of global best practice.
Secure Data Sharing and Privacy Preserving Authentication Protocol for Cloud Environment

: Cloud computing is an evolving data interactive paradigm to perceive user’s data remotely stored in an online cloud server. It provides great benefits for the users to enjoy the on-demand cloud applications without considering the local infrastructure restrictions. During the data accessing, different users may be in alliance, and thus data sharing becomes remarkable to achieve productive advantages. The existing security solutions mainly focus on the authentication to realize that a users destitution data cannot be illegally accessed, but neglect a minute privacy matter during a user challenging the cloud server to request other users for data sharing. The challenged access request itself may disclose the users privacy no matter whether or not it can obtain the data access permissions. The proposed system suggest a multi-user sharing privacy-preserving authentication protocol to address above privacy issue for cloud storage.
How People Really Use the Mobile Web: A Framework for Understanding Motivations, Behaviors, and Contexts

Mobile data services offer a viable and growing alternative means of accessing the World Wide Web and have drawn significant attention from the mobile industry. However, design efforts are hampered by the fact that we do not fully understand people’s motivations, behaviors, and contexts of use when they access the Web on their phones in naturalistic settings. To help address this need, the authors conducted a study to explore the following questions for U.S. mobile phone users: (1) What motivations lead people to access the Web on their mobile phones? ;(2) What do they do? ; and (3) Where do they do it? We studied active U.S. mobile Web users via questionnaires, semi-structured interviews, and a field diary system that participants used to record their daily Web activities. Based on the findings from Part One of the study, they constructed a taxonomy of behaviors, motivations, and contexts associated with mobile Web usage. In Parts Two and Three, the authors validated the taxonomy as well as compared iPhone versus non-iPhone user behaviors. The authors conclude this report of the three-part study by considering the design implications of their findings and future research directions for further understanding the mobile Web.
Plastic multiwell plates to assay avian infectious bronchitis virus in organ cultures of chicken embryo trachea

Simple assay systems for infectivity titrations of avian infectious bronchitis virus (IBV) in chicken embryo trachea organ cultures (OC) were developed using plastic multiplate wells with one tracheal ring per well; these assays appeared to be much more satisfactory than the conventional rolled-tube method. The medium, 0.05 M HEPES (N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid)-buffered Eagle minimal essential medium was not changed during observation. A medium containing 0.4% bovine serum albumin did not influence the virus yield, but did stabilize virus viability during storage. Reproducibility of results obtained in the OC system was confirmed by performing replicate titrations of the Beaudette strain with three different passage histories. The mean virus titers in the OC were lower than those in chicken embryos, depending on the IBV passage histories. The time required for ciliostasis was related not only to the concentration of virus, but also to the IBV passage history. Application of OC techniques for the constant serum-variable virus neutralization test gave low neutralization indexes with excellent reproducibility as compared with those obtained in the chicken embryo assay system. Also, the slopes of neutralization curves obtained by assays in OC were less steep than those seen in the chicken embryo system.
Blogging by the dead

In this article we present a concept for a ubiquitous service that allows memories to be saved and stored during an individual's lifetime, and later, after death, for those memories to be published and experienced at the specific geographic location where they were created. We call this concept Blogging by the Dead. The proposed technical solution for publishing memories at a specific geographic location is based on current existing technologies, and consists of a cross between GPS systems, mobile Internet, and fixed Internet. Through the concept of Blogging by the Dead we explore ways to combine modern technology with century old habits at the end of life.