Miracle-dz/UniFAR-FTUs huggingface dataset:
During apoptosis of HL-60 and U-937 cells caspases are activated independently of dissipation of mitochondrial electrochemical potential.

Collapse of the mitochondrial potential (DeltaPsi(m)) during apoptosis has been linked with a release of cytochrome c and apoptosis-inducing factor (AIF) and activation of caspases. Using a laser scanning cytometer (LSC), an instrument that allows one to measure the same cells twice, first when they are alive and subsequently after their permeabilization, we explored whether dissipation of DeltaPsi(m) (measured supravitally) is a prerequisite for the activation of caspases (detected after cell fixation). Apoptosis of HL-60 cells was induced either by TNF-alpha combined with cycloheximide (CHX) or by the DNA topoisomerase I inhibitor camptothecin (CPT) and of U-937 cells by CPT, and DeltaPsi(m) was measured using the carbocyanine fluorochrome DiIC(1) (5). The marker of caspase activation was specific cleavage of poly(ADP) ribose polymerase (PARP) detected immunocytochemically. After 30 or 60 min treatment with TNF-alpha + CHX or 60 or 120 min with CPT a considerable proportion of cells (20-40%) demonstrated PARP cleavage with no evidence of DeltaPsi(m) collapse. Also present in these cultures (3-20%) were cells with collapsed DeltaPsi(m) whose PARP was not cleaved. The results provide direct evidence that in HL-60 and U-937 cells treated with TNF-alpha + CHX or CPT the dissipation of DeltaPsi(m) is not required for activation of caspases and these two events are independent of each other.
Using Cooja for WSN Simulations: Some New Uses and Limits

The Cooja/MSPSim network simulation framework is widely used for developing and debugging, but also for performance evaluation of WSN projects. We show in this paper that Cooja is not limited only to the simulation of the Contiki OS based systems and networks, but can also be extended to perform simulation experiments of other OS based platforms, especially that with RIOT OS. Moreover, when performing our own simulations with Cooja and MSPSim, we observed timing inconsistencies with identical experimentations made on actual hardware. Such inaccuracies clearly impair the use of the Cooja/MSPSim framework as a performance evaluation tool, at least for time-related performance parameters. We will present in this paper, as our contributions: On the one hand, how to use Cooja with projects not related to Contiki OS; On the other hand, the detailed results of our investigations on the inaccuracy problems, as well as the consequences of this issue, and give possible leads to fix or avoid it.
Prematurity at birth and adolescent depressive disorder

Summary Association between prematurity/low birthweight and adolescent depressive disorder studied using a case–control design within a prospective cohort study of 2032 adolescents. Odds for depressive disorder were 11-fold (95% C12–62) higher for the premature/low-birthweight participants after regression adjustment for major confounding factors. For premature/low-birthweight females, cumulative rates of depressive disorder over 30 months were 15.2% (95% C111.1–20.5) v. 1.8% (95% C11.6–2.1) in those with normal deliveries. Physiological adaptations in utero before full term may be implicated causally in some cases of depression in adolescence.
MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: Introducing microRNA pharmacogenomics

MicroRNAs are evolutionarily conserved small non-coding RNAs known to inhibit the translation of proteins by binding to the target transcript in the 3’ untranslated region. Functional polymorphisms in 3’ UTRs of several genes have been reported to be associated with diseases by affecting gene expression. The mechanism by which these polymorphisms affect gene expression and induce variability in a cell is not well understood. It has been suggested that these polymorphisms may interfere with regulatory elements that bind to untranslated region of a gene. Recently, a novel class of functional polymorphisms termed miRSNPs/polymorphisms was reported.1, 2 defined as a polymorphism present at or near a microRNA binding sites of functional genes that can affect gene expression by interfering with a miRNA function. The work elucidated the mechanism of a functional miRSNP 829C→T present in 3’ UTR of dihydrofolate reductase, an important drug target. The SNP interferes with the miR24 microRNA function and leads to DHFR over expression and methotrexate resistance. In this article we highlight the importance of these miRSNPs or miR-polymorphisms in gene regulation and the mechanism by which these miRSNPs can induce variability in the SNP expressing mutant cell by using drug resistance as an example.
Non-respiratory Symptoms and Well-Being in Asthmatics from a General Population Sample

Background. Different instruments have been developed to assess health-related quality of life (HRQL) in asthma patients. However, relatively few studies have assessed HRQL in asthma patients from a general population, and it is still unclear which instrument is most suitable. The purpose of this study was to compare HRQL in clinically verified asthmatics with subjects with respiratory symptoms without asthma and with subjects with no respiratory symptoms from a general population. The generic instrument Gothenburg Quality of Life (GQL) was used. A secondary aim was to study if GQL had any prognostic value in asthma. Methods. A cohort of three age groups in Sweden was investigated in 1990 using a respiratory questionnaire and GQL. The cohort consisted of 616 subjects with asthma, 488 subjects with respiratory symptoms but no asthma, and 347 subjects without respiratory symptoms. The participants were also investigated by spirometry and allergy testing. In a follow-up study, subjects were identified who had persistent and improved asthma. Results. The prevalence of 28 of the 30 common symptoms in GQL was significantly increased (p < 0.001) in subjects with asthma as compared to non-asthmatics. All symptoms in the domains heart and lung, head, musculoskeletal, tension, and depression were significantly increased among the asthmatics. The asthmatics also rated their physical well-being lower (p < 0.001) than subjects with no respiratory symptoms. Subjects with persistent asthma had a significantly higher prevalence of 7 of the 30 symptoms and lower social well-being than subjects showing improvement in asthma during the follow-up. All differences remained significant after adjusting for age, sex, and smoking habits. Conclusion. Subjects with asthma had different symptom-profiles compared to those of non-asthmatics, with a higher prevalence of both respiratory and non-respiratory symptoms. Asthma is also a disease that is related to low well-being. The use of quality-of-life questionnaires such as the GQL may provide useful information for evaluating the non-respiratory aspects of asthma as well as for assessing the impact of disease on health status and well-being.
A Dual-Port Access Structure of 3D Mesh-Based NoC

Since the length of wires between different layers, even between the top and bottom layers, is acceptably small in 3D mesh-based NoC (three-Dimensional mesh-based Network on Chip), a structure in which an IP (Intelligence Property) core in a certain layer directly connected to a proper router in another layer may efficiently decrease the average latency of messages and increase the maximum throughput. With this idea, in the paper, we introduce a dual-port access structure, in which each IP core except that in the bottom layer is connected to two routers in two adjacent layers, and, in particular, the IP core in the bottom layer can be directly connected to the proper router in the top layer. Furthermore, we derive the close form expression of the average number of hops of messages and also give the quantitative analysis of the performance when the dual-port access structure is used. All the analytical results reveal that the average number of hops is reduced and the system performance is improved, including a decrease of average latency and an increase of maximum throughput. Finally, the simulation results confirm our theoretical analysis and show the advantage of the proposed dual-port access structure with a relatively small increment of area overhead.
Bio-database compression using enhanced suffix array for pairwise sequence alignment

Sequence alignment is a bioinformatics application that determines the degree of similarity between nucleotide or amino acid sequences which is assumed to have same ancestral relationships. This sequence alignment method reads query sequence from the user and makes an alignment against large and genomic sequence data sets and locate targets that are similar to an input query sequence. Traditional accurate algorithm, such as Smith-Waterman and FASTA are computationally very expensive, which limits their use in practice. The current set of popular search tools, such as BLAST and WU-BLAST, employ heuristics to improve the speed of such searches. However, such heuristics can sometimes miss targets, in which many cases are undesirable. This paper provides BioDB Compression Tool using enhanced suffix array, to perform accurate and faster biological sequence analysis as an improvement on the computation time of existing tools in this area using data base compression. The main idea is to pick matched patterns of the query sequence and identify sequences in the database which share a large number of these matched patterns, thereby compressing the size of the database to very few sequences. Experiment results are cross validated using data mining technique. This shows that a new BioDB Compression developed effectively compresses the database and obtains very similar results compared to that traditional algorithm in approximately half the time taken by them.
Codon 219 polymorphism of PRNP in healthy Caucasians and Creutzfeldt-Jakob disease patients.

A number of point and insert mutations of the PrP gene (PRNP) have been linked to familial Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler-Scheinker disease (GSS). Moreover, the methionine/valine homozygosity at the polymorphic codon 129 of PRNP may cause a predisposition to sporadic and iatrogenic CJD or may control the age at onset of familial cases carrying either the 144-bp insertion or codon 178, codon 198, and codon 210 pathogenic mutations in PRNP. In addition, the association of methionine or valine at codon 129 and the point mutation at codon 178 on the same allele seem to play an important role in determining either fatal familial insomnia or CJD. However, it is noteworthy that a relationship between codon 129 polymorphism and accelerated pathogenesis (early age at onset or shorter duration of the disease) has not been seen in familial CJD patients with codon 200 mutation or in GSS patients with codon 102 mutation, arguing that other, as yet unidentified, gene products or environmental factors, or both, may influence the clinical expression of these diseases. 17 refs.
Construction d'une ontologie à partir d'une base de données relationnelle : approche dirigée par l'analyse des formulaires HTML

L'emergence et la generalisation du Web dans tous les domaines, a permis a de nombreuses entreprises d'offrir une variete de services et d'informations en ligne, suscitant ainsi un reel besoin de partage et d'interoperabilite. Cela necessite une infrastructure permettant a des agents logiciels d'exploiter, de composer et de raisonner sur les contenus constituants les ressources Web. Malheureusement, la notion d'ontologie qui est souvent au c½ur de cette infrastructure, n'est pas toujours disponible. Pour contribuer a resoudre ce probleme, nous preconisons un processus semi-automatique d'acquisition d'ontologie OWL a partir d'une base de donnees relationnelle en analysant par des techniques de retro ingenierie les formulaires HTML relatifs a une application web. L'objectif de cette demarche et de rendre exploitables par les machines, les bases de donnees relationnelles disponibles sur le Web, reduisant ainsi le cout de construction des ontologies.
Kummer's Special Case of Fermat's Last Theorem

One particularly elegant example of an application of modern algebraic number theory to a classical problem about the integers is found in Kummer’s special case of Fermat’s Last Theorem. In this paper, we reduce Fermat’s Last Theorem to the question of whether or not there exist integer solutions to x p + y p = z p for p an odd prime. We then give a thorough exposition of Kummer’s proof that no such solutions exist in the case that p does not divide the class number of Q(e 2i/p ), that is where p is a regular prime.
Generalized Kohn-Sham schemes and the band-gap problem.

As an alternative to the standard Kohn-Sham procedure, other exact realizations of density-functional theory ~generalized Kohn-Sham methods! are presented. The corresponding generalized Kohn-Sham eigenvalue gaps are shown to incorporate part of the discontinuity D xc of the exchange-correlation potential of standard KohnSham theory. As an example, a generalized Kohn-Sham procedure splitting the exchange contribution to the total energy into a screened, nonlocal and a local density component is considered. This method leads to band gaps far better than those of local-density approximation and to good structural properties for the materials Si, Ge, GaAs, InP, and InSb.
Repeated Games, Duality and the Central Limit Theorem

This paper is concerned with the repeated zero-sum games with one-sided information and standard signaling. We introduce here dual games that allow us to analyze the “Markovian” behavior of the uninformed player, and to explicitly compute his optimal strategies. We then apply our results on the dual games to explain the appearance of the normal density in the n-1/2-term of the asymptotic expansion of vn as a consequence of the Central Limit Theorem.
An Approximate Scheme of Oblivious Transfer with Probabilistic Receipt

An efficient scheme is proposed which achieves the oblivious transfer with probabilistic receipt, α-OT, approximately for 0 < α < 1. The proposed scheme approximates α-OT with 2−i-OT for i = 1, 2, . , k. It implements γ-OT for some γ such that (α − 2−k)/(1 − 2−k) < γ ≤ α with − log(1 − α) invocations of 2−1-OT and at most 2 invocations of 2−i-OT for each i = 2, . , k. These invocations can be executed in parallel. key words: oblivious transfer, approximation
Functional connectivity of dissociation in patients with psychogenic non-epileptic seizures

Introduction Psychogenic non-epileptic seizures (PNES) resemble epileptic seizures, but lack epileptiform brain activity. Instead, the cause is assumed to be psychogenic. An abnormal coping strategy may be exhibited by PNES patients, as indicated by their increased tendency to dissociate. Investigation of resting-state networks may reveal altered routes of information and emotion processing in PNES patients. The authors therefore investigated whether PNES patients differ from healthy controls in their resting-state functional connectivity characteristics and whether these connections are associated with the tendency to dissociate. Methods 11 PNES patients without psychiatric comorbidity and 12 healthy controls underwent task-related paradigms (picture-encoding and Stroop paradigms) and resting-state functional MRI (rsfMRI). Global cognitive performance was tested using the Raven's Matrices test and participants completed questionnaires for evaluating dissociation. Functional connectivity analysis on rsfMRI was based on seed regions extracted from task-related fMRI activation maps. Results The patients displayed a significantly lower cognitive performance and significantly higher dissociation scores. No significant differences were found between the picture-encoding and Stroop colour-naming activation maps between controls and patients with PNES. However, functional connectivity maps from the rsfMRI were statistically different. For PNES patients, stronger connectivity values between areas involved in emotion (insula), executive control (inferior frontal gyrus and parietal cortex) and movement (precentral sulcus) were observed, which were significantly associated with dissociation scores. Conclusion The abnormal, strong functional connectivity in PNES patients provides a neurophysiological correlate for the underlying psychoform and somatoform dissociation mechanism where emotion can influence executive control, resulting in altered motor function (eg, seizure-like episodes).
NI FROM FIRST-PRINCIPLES : IMPLICATIONS FOR TAILORING THE CREEP RATE OF NI-BASE SUPERALLOYS

To understand the effects of alloying elements on t he creep rate of Ni-base superalloys, factors entering into a second ary creep rate are calculated via first-principles calculations ba sed on density functional theory for 26 Ni 31X systems where X = Al, Co, Cr, Cu, Fe, Hf, Ir, Mn, Mo, Nb, Os, Pd, Pt, Re, Rh, Ru, Sc, i, Ta, Tc, Ti, V, W, Y, Zr, and Zn. They are volume, elastic prop erties, stacking fault energy, and diffusivity. It is foun d that shear modulus, Young’s modulus, and roughly stacking faul t energy show inverse correlation to the atomic volume of th e system. In addition, the closer the alloying elements to Ni, w ith respect to atomic volume and atomic number, the larger the pre dict d shear modulus, Young’s modulus, and stacking fault energy . Diffusivity calculations show that mid-row 5d trans ition metal elements, particularly Re, Os, and Ir, have the hig hest activation barrier for diffusion, while far-right or far-left row placement elements such as Y, Zn, and Hf, have the lowest act ivation energy barriers for diffusion. A creep rate ratio of ⁄ is calculated and the effect of the alloying elements shows 13 systems have a decreased creep rate relative to Ni, while 13 systems have an increased creep rate relative to Ni .
Time-variant characteristics for Vehicle-to-Vehicle communications in highway scenario

This paper presents the geometry-based stochastic model for V2V channels in highway scenario. The channel multipath components are divided into several taps by utilizing the method of tapped delay line structure, and the Doppler properties of each tap are analyzed. The time-variant characteristics as well as their influences on power spectrum density, Doppler shift and root mean square delay spread are presented.
On Enterprise Information System Research Trend—Based on the Keywords Frequency Analysis of Journal EIS 2007-2015

The journal of Enterprise Information Systems (EIS) was founded in 2007 by Taylor & Francis, selected by the Web of Science Citation Index Expanded in 2008, and included in EI. The research collects 219 papers published in the EIS from 2007 to 2015, and explores valuable information such as the present situation and hotspot trends in the research of the enterprise information systems by extracting and analyzing the keyword of those papers. Finally, we analyze and comment on 9 related papers with considering the trends: enterprise architecture, cloud computing services, ontology and semantic, data science and social networking, enterprise integration and systems science. The research can help relevant scholars to understand EIS research situation, and have a mind to EIS research trends.
PI3K: a rational target for ovarian cancer therapy?

Commentary to: Validation and Toxicity of PI3K/Akt Pathway Inhibition by HIV Protease Inhibitors in Humans John P. Plastaras, Neha Vapiwala, Mona S. Ahmed, Deborah Gudonis, George J. Cerniglia, Michael D. Feldman, Ian Frank, Anjali K. Gupta
PROJECT SUMMARY MEASUREMENT ERROR ESTIMATION AND CORRECTION METHODS TO MINIMIZE EXPOSURE MISCLASSIFICATION IN EPIDEMIOLOGICAL STUDIES

This project summary highlights recent findings from research undertaken to develop improved methods to assess potential human health risks related to drinking water disinfection byproduct (DBP) exposures. The primary objective of this research was to examine the utility of routinely collected monitoring data to estimate individual-level exposures in epidemiological studies. Another specific aim was to estimate the potential for exposure misclassification bias due to a variety of sources including (1) unmeasured spatial variability in town average surrogate measures and (2) lack of integration of individual water use practices data including exposure-modifying factors. In addition to quantifying potential exposure misclassification bias, we developed an approach to correct for measurement error that may cause this bias.
Cloud Computing - An on Demand Service Platform

computing required number of hardware and software resources which continuously changed or upgraded thus requiring customers and users to consistently pump in investments to upgrade their infrastructures. This required researchers to arrive at a solution where users and customers would have access to latest versions of hardware and software without requiring new investments. This led to the very concept of cloud computing where a customer or user pays only for the service rather than for the product (1). This paper is a base paper that gives a brief introduction to the cloud computing, from what technologies cloud computing is derived, its components, its merits and demerits, also main challenges to the cloud computing. This paper also helps to categorize the various services provided by any cloud service provider in some categories depending upon the type of service.
Exciton–erbium coupling and the excitation dynamics of Er3+ in erbium-doped silicon-rich silicon oxide

The exciton–erbium coupling and the excitation dynamics of Er3+ in erbium-doped silicon-rich silicon oxide are investigated using time-resolved measurements of Er3+ luminescence. The dependence of the Er3+ luminescence on the pump power and duration indicates that the exciton–erbium coupling is dominant over carrier–exciton coupling. The results further support the idea that the luminescent Er3+ ions are not in the Si nanoclusters but in the interface region surrounding the nanoclusters.
Structure of insulin: results of joint neutron and X-ray refinement.

Neutron diffraction data for porcine 2Zn insulin were collected to 2.2 A resolution from a single crystal deuterated by slow exchange of mother liquor. A joint neutron/X-ray restrained-least-squares refinement was undertaken using the neutron data, as well as the 1.5 A resolution X-ray data collected previously. The final R factors were 0.182 for the X-ray data and 0.191 for the neutron data. Resulting atomic coordinates were compared with the initial X-ray model, showing a total r.m.s. shift of 0.36 A for the protein and 0.6 A for the solvent. Protonation of a number of individual amino acids was investigated by analysis of the neutron maps. No D atoms were found between the carboxylates of Glu B13 which make an intermolecular contact, suggesting nonbonded interaction rather than the predicted hydrogen bond. Amide hydrogen exchange was investigated in a refinement of their atomic occupancies. Regions of unexchanged amide groups were found in the center of the B helices. The results of this study emphasize the limited amount of information available in neutron diffraction studies of proteins at resolution lower than 2 A.
mRNA EXPRESSION OF THE LIPID AND MECHANO-GATED 2P DOMAIN K + CHANNELS DURING RAT BRAIN DEVELOPMENT

mRNAs encoded by genes for the lipid-sensitive mechano-gated K + channels TREK-1, TREK-2, and TRAAK were detected in rat brain at different life-cycle stages: 18-day embryos, postnatal days 1, 7, 28, and 60 (adulthood). mRNA expression of TREK-1 or TREK-2 showed no appreciable changes during the development of cortex and hippocampus. TRAAK mRNA expression increased with development and reached an apparent maximum at postnatal day 28 in hippocampus and day 60 in cortex. These data suggest that TRAAK might be important in the development of rat brain.