Miracle-dz/UniFAR-FTUs huggingface dataset:
A study of regulatory T cells in allogeneic haematopoietic stem cell transplantation

vi Declarations . vii Acknowledgements . viii Abbreviations . ix 1. Introduction . 1 1.1 History of Allogeneic Haematopoietic Stem Cell Transplantation . 3 1.2 Current Allogeneic Haematopoietic Stem Cell Transplantation . 5 Pre-­‐Transplant Conditioning . 5 1.2. 1 Donor Selection . 6 1.2. 2 Stem Cell Source . 7 1.2. 3 Graft Manipulation . 8 1.2. 4 1.3 Engraftment and Immune Reconstitution . 10 1.4 Graft-­‐versus-­‐Host Disease . 12 Acute Graft-­‐versus-­‐Host Disease . 12 1.4. 1 Chronic Graft-­‐versus-­‐Host Disease . 17 1.4. 2 1.5 Other Complications of Haematopoietic Stem Cell Transplantation . 23 Failed Engraftment . 23 1.5. 1 Relapse . 23 1.5. 2 Infection . 24 1.5. 3 1.6 Regulatory T cells . 25 Human Treg markers . 25 1.6. 1 Treg Development . 28 1.6. 2 Treg Function . 30 1.6. 3 1.7 Regulatory T cells in Allogeneic Haematopoietic Stem Cell Transplantation . 32 Regulatory T cells and Graft-­‐versus-­‐Host Disease . 33 1.7. 1 Increasing Regulatory T cells Post-­‐Transplant . 35 1.7. 2 1.8 Aims and Hypotheses . 40
Implementation of the Wang Landau Algorithm to Cubic Lattice Knots

The mathematical study of circular polymers in biology and medical science often involves modeling them as 3-dimensional self avoiding polygons as using sampling algorithm to understand their behaviour. The BFACF Algorithm is an ergodic Markov Chain Monte Carlo method that samples the space of self-avoiding lattice polygons of fixed knot type and varying length. However, using this method to generate large independent and identically distributed(iid) sets of polygons is expensive computationally and challenging as the length of the chain increase. With the objective to improve the sampling efficiency and expand the functionality of the sampling process, we implement the Wang Landau algorithm. This algorithm provides an improved way to sample polygons related by BFACF moves; also, it samples uniformly with respect to different energies, such as writhe and bending energy. In this work, we compared the sampling distribution obtained by each algorithm for a variety of knot types and lengths. The comparison shows high coherency between these two sampling methods, which validates the implementation. The Wang Landau algorithm provides a more efficient and precise tool that helps us understand the behavior of polymers. Sampling data obtain by Wang Landau algorithm shows the relative probability of pairwise energy states and overall distribution for all energy states.
A testbed for cybersecurity assessment of industrial and iot-based control systems

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. A testbed for cybersecurity assessment of industrial and iot-based control systems Mohamad Kaouk, Francois-Xavier Morgand, Jean-Marie Flaus
Chapter 6 Domestication and Welfare in Farmed Fish

The domestication of fish species is still in its early stages when compared to terrestrial animals. The effects of domestication on welfare of farmed fishes are complex to study because fish differ from livestock in genetics, physiology and behaviour, and experience different sensory worlds. Consequently, empathy with fish and understanding of their needs becomes more problematic than with land animals. Additionally, the acknowledgement and study of mental dimensions of fish existence is very recent. We discuss that higher levels of domestication in fish do not necessarily correspond to better welfare because (1) artificial selection by the aquaculture industry is mostly focused on production-related traits such as growth, and this selection process may have unknown negative effects on welfare-related traits; (2) the number of fish species presently farmed (circa 300) is 10-fold higher than land animals, rendering the establishment of standard welfare guidelines extremely complicated; (3) the current paradigm of the Five Freedoms guiding welfare is out-dated and was designed for livestock; and (4) there are still severe knowledge gaps in the biology of farmed fishes, especially in welfare-related traits. The implementation of humane farming systems should integrate industry, science and ethics in an open dialogue in order to produce relevant results.
On-orbit Potential Measurement of H-II Transfer Vehicle

No.165 On-orbit Potential Measurement of H-II Transfer Vehicle Abstract— JAXA developed the Advanced Technology Onorbit Test Instrument for space Environment-mini (Atotie-mini) with Kyushu Institute of Technology to measure the potential of H-II Transfer Vehicle. The following issues are reported in this report. Atotie-mini integrated on HTV-4 was launched on August 4 2013. Atotie-mini was automatically activated when HTV-4 arrived at the orbit, and started the potential measurement. Atotie-mini acquired the potential data for approximately one month, which was almost equal to the entire operation time of HTV. During the operation, the HTV potential shows -25V to 40V in sunshine. The measurement results on several operation phase of HTV are reported in detail. JAXA developed the Advanced Technology Onorbit Test Instrument for space Environment-mini (Atotie-mini) with Kyushu Institute of Technology to measure the potential of H-II Transfer Vehicle. The following issues are reported in this report. Atotie-mini integrated on HTV-4 was launched on August 4 2013. Atotie-mini was automatically activated when HTV-4 arrived at the orbit, and started the potential measurement. Atotie-mini acquired the potential data for approximately one month, which was almost equal to the entire operation time of HTV. During the operation, the HTV potential shows -25V to 40V in sunshine. The measurement results on several operation phase of HTV are reported in detail. Keywords—HTV, Potential measurement, Plasma interactions.
1 5 A pr 2 01 9 Dynamically Generated Synthetic Electric Fields for Photons

Static synthetic magnetic fields give rise to phenomena including the Lorentz force and the quantum Hall effect even for neutral particles, and they have by now been implemented in a variety of physical systems. Moving towards fully dynamical synthetic gauge fields allows, in addition, for backaction of the particles’ motion onto the field. If this results in a time-dependent vector potential, conventional electromagnetism predicts the generation of an electric field. Here, we show how synthetic electric fields for photons arise self-consistently due to the nonlinear dynamics in a driven system. Our analysis is based on optomechanical arrays, where dynamical gauge fields arise naturally from phonon-assisted photon tunneling. We study open, one-dimensional arrays, where synthetic magnetic fields are absent. However, we show that synthetic electric fields can be generated dynamically. The generation of these fields depends on the direction of photon propagation, leading to a novel mechanism for a photon diode, inducing nonlinear unidirectional transport via dynamical synthetic gauge fields.
Policy of Universal Basic Education in Nigeria : An Examination of its Effectiveness on Implementation and Management

The intention of this paper is to thoroughly discuss the universal basic education in Nigeria, from its overview, how it was in the past to its expected outcome. In this paper, we examine the effectiveness in terms of aims, implementation and plan of action regarding Nigerian policy of universal basic education. The paper further discusses alternative courses of action to enhance parents understanding on the importance of education so that they can share the same value to their children. In addition, we also emphasize the provision of training and education for teachers is to increase their teaching competency and enhance their influential in the quality of basic education in the country. The presence of transparency and accountability especially from the management of funds which come from donors, such as private individuals and significant international actors is significantly emphasized.
A simple and fast sampling method for chemical analyses and densitometry of bones through rib biopsies in cattle 1

Malafaia P., Salcedo Y.T. G. , Uscategui R.A. R. , Souza V.C. , Costa D.F. A. & Berchielli T.T. 2017. A simple and fast sampling method for chemical analyses and densitometry of bones through rib biopsies in cattle. Pesquisa Veterinária Brasileira 37(1):31-35. Departamento de Nutrição Animal e Pastagem, Instituto de Zootecnia, Universidade Federal Rural do Rio de Janeiro, Campus de Seropédica, BR 465-Km 7, Seropédica, RJ 23890-000, Brazil. E-mail: malafaia_ufrrj@yahoo.com. br We developed and evaluated a fast and simple method to obtain suitable bone samples for densitometry and chemical analysis through biopsies of the 12th rib of cattle. The postoperative recovery, dry matter intake (DMI) and average daily weight gain (ADG) was evaluated in 36 Nellore steers, nine of which were randomly selected for the control group and 27 others were rib biopsied. Every 30 days, rib biopsy was performed in nine steers, using a corded-electric pistol-grip drill coupled with a hole saw of a 3mm diameter pilot drill bit. This rib biopsy technique provided a suitable sample obtained in a fast way and allowed the surgeon to work alone with the animal slightly sedated and restrained in the crush. Dry matter intake (DMI) was not affected in biopsied animals. At the end of the experimental period (116 days) the average daily weight gain (ADG) was similar in the steers biopsied or not. The described method provided rib samples from cattle suitable for densitometry and chemical analysis of bone tissue without effects on health and performance. This information could greatly increase the accuracy for the diagnosis of phosphorus deficiency in cattle raised on pasture and allow the evaluation of bone metabolism in experimental animals.
determiner under balancing selection Duplication and concerted evolution in a master sex

Supplementary data tml http://rspb.royalsocietypublishing. org/content/suppl/2013/03/05/rspb.2012. 2968.DC1. h "Data Supplement" References http://rspb.royalsocietypublishing. org/content/280/1758/20122968.full. html#ref-list-1 This article cites 63 articles, 37 of which can be accessed free Subject collections (122 articles) molecular biology  (1436 articles) evolution  (24 articles) bioinformatics  Articles on similar topics can be found in the following collections
An integrative method for microRNA target prediction

MicroRNAs (miRNAs) are small non-coding RNA molecules that are critical to gene expression in human cells. They typically act as silencers, inhibiting genes through protein-mediated interactions with target mRNA transcripts that share certain complementary sequences with the miRNA. In light of recent findings that miRNA exists outside the cell as a means of cell-to-cell communication, it is becoming increasingly important to be able to identify mRNA targets of individual miRNAs. Several purely sequence-based approaches to miRNA target prediction already exist—typically using rule-based approaches to calculate scores based on free energy and sequence complementarity—but they suffer from high false-positive rates and individually consider only a narrow subset of features known to be significant. It would be useful to integrate such approaches with experimental datasets, such as those generated by HITS-CLIP, with the aim of enhancing the specificity of target prediction. To this end, I review existing methods, then present an initial attempt to develop a predictive model derived from the integration of the TargetScan and miRanda algorithms with HITS-CLIP and expression datasets.
A Simulation Model of a Pull Production System for a Flexible PCB Assembly Line

We consider the production system of one model of flexible printed circuits (FPCs) that has the highest production volume. Currently, it operates under a push system, which has flow time higher than the target and high work in process (WIP). The management wants to see if the Kanban system can solve these issues. We develop simulation models of the current push system and the proposed Kanban system to determine the optimal lot size that yields low flow times and low WIP. To combine both measures, we consider the production cost. The optimal lot size is found to be 25 sheets (1 sheet consists of 10 FPCs). At this lot size, the flow time to produce 16,000 FPCs reduces from 59,800 seconds to 52,600 ± 10.10 seconds (-12%), and the WIP level decreases from 409 pieces to 156 pieces (-62%).
Revisiting the Multipurpose Property of Sampling Weights

The recent article by Professor R.J.A. Little (Little 2012) includes a discussion of alternative basic philosophies of official statistics production. In this letter, we wish to bring to the attention of JOS readers another, related fundamental property of significance for official statistics production, which we believe is related to the matter that Prof. Little discusses. Use of sampling weights is a feature that probably distinguishes survey sampling most from other statistical disciplines. In survey practice, statisticians have traditionally called for them to satisfy the so-called multipurpose property (Särndal 2007), that is, that a single set of sampling weights is used to estimate all population variables in a multipurpose survey. Another key concept in official statistics production is auxiliary information. It occurs at different stages: the sampling design (Cochran 1977), the construction of estimators (Särndal et al. 1992), the treatment of nonresponse (Särndal and Lundström 2005), the imputation methods (Haziza 2009), to name perhaps the most noteworthy. Auxiliary information in statistical offices is nowadays abundant, available, up-to-date and of good quality for statistical purposes. We contend that this increasing availability of auxiliary information invites us to consider putting aside the multipurpose property. We reason as follows. From a purely theoretical standpoint, there is no reasoning that supports the multipurpose property. Moreover, adhering to methodological rigour in sampling weights construction, one can easily find reasons not to have a single set of weights. Let us consider, for instance, nonresponse treatment. Reweighting for nonresponse (see e.g., Särndal and Lundström 2005; Bethlehem et al. 2011) is an elaborate technique where either calibrating against benchmark auxiliary information or modelling response propensity (also using auxiliary information) assists in the weight adjustment and bias reduction. Regarding calibrating, to take a specific example, the following statement by Ranalli (2008) is enlightening in this respect:
Measuring spatial mobility using cell phone data-towards new perspectives on accessibility

Mohall, M. 2015. Measuring spatial mobility using cell phone data – towards new perspectives on accessibility. Kulturgeografiska institutionen, Arbetsrapportserie, Uppsala universitet. In recent years, spatial data derived from cell phones has become increasingly recognized as a valuable data source for urban analysis. Using a sizeable dataset depicting the physical movements of several million Swedish and Danish cell phones during 24 hours, an analysis of aggregated individual mobility levels and mobility patterns is conducted. The analysis covers two measurements of mobility, total diurnal mobility and commuting mobility. Findings indicate that phone data may provide seminal insights on otherwise scarcely accessible information on how space is experienced and interacted with depending on the individual's residential location. The data is analysed using a broad set of spatial analysis techniques incorporating both statistical and visual representations of spatial mobility and spatial relationships.
Individual characteristics that determines re-employment probabilities of displaced workers in Sweden

This paper studies the relationship between individual characteristics of displaced workers and the probability of re-employment. A competing risks hazard model is used, distinguishing between exits from joblessness to self-employment and to paidemployment respectively. All individuals that were between 25 and 55 years of age at the time of displacement, that suffered from at least one year of joblessness after being displaced between 1990 and 1998 due to establishment closures that occurred between 1990 and 2001 are included, allowing for the closure procedure to be between one and three years long. Each individual is followed, from the year of displacement until the year of re-employment or at the latest, ten years after displacement. Semi-parametric estimation techniques for discrete time data are used, and in consistency with previous research the results show that subgroups of the jobless individuals experience different re-employment probabilities. The results suggest that a non-immigrant, high incomeearner in the mid-thirties, with short tenure at the closing establishment, and who was not displaced early in the closure process and who has lived in the same city for a long time, faces the greatest probability of becoming re-employed. Furthermore, men and individuals with self-employment experience face lower probabilities of re-employment in paid-employments compared to their counterparts. This relationship is however reversed when studying the probability of leaving joblessness for self-employment. Men, immigrants, high income-earners, displaced from smaller establishments, previously self-employed and those with shorter tenure in previous employment are found to be more likely to enter self-employment than their counterparts. Positive duration dependence is prevalent in re-employment probability, suggesting that search activity is increased or reservation wage decreased over time. The probability of self-employment entry is however decreasing the first years of joblessness following displacement, displaying initial negative duration dependence.
Establishing a sound foundation through electroacoustic verification

Within Early Hearing Detection and Intervention (EHDI) programs, timely and accurate hearing assessment establishes the groundwork for early and optimal intervention for infants with permanent hearing loss. Many families choose personal hearing aids as part of a comprehensive intervention program for their child with hearing loss. Audiologists who provide hearing aids to the pediatric population have a responsibility to provide safe, accurate, and suitable hearing aids to their patients. The appropriateness of the hearing aid fitting is a critical component to achieving successful outcomes for children with hearing loss. This paper describes current, evidence-based strategies for the fitting of hearing aids to the pediatric population. Recent guidelines and protocols will be reviewed with a goal to highlight relevant clinical procedures. The importance of measuring the real-ear-to-coupler difference (RECD) and how it is applied in the pediatric hearing aid fitting process will be examined. Simulated (coupler-based) real-ear verification will also be described to support the evaluation of hearing aid performance in relation to individualized prescriptive targets. These components provide a solid foundation for optimal communication development opportunities for infants and young children who wear hearing aids. 12
Commutation Cell for Battery Charging using PV Panels in A Single Conversion Stage by using High-Voltage Gain Boost Converter C

This paper presents a novel high-voltage gain boost converter topology based on the three-state commutation cell for battery charging using PV panels and a reduced number of conversion stages. The presented converter operates in zero-voltage switching (ZVS) mode for all switches. By using the new concept of single-stage approaches, the converter can generate a dc bus with a battery bank or a photovoltaic panel array, allowing the simultaneous charge of the batteries according to the radiation level. The operation principle, design specifications, and experimental results from a 500-W prototype are presented in order to validate the proposed structure.
Study of Structural and Electronic Properties of KCaF 3 Type Fluoro-Perovskite

Results of structural and energy bands in case of KCaF3 fluoro perovskite is presented in this paper. Calculation is done by using full-potential linearized augmented plane wave (FP-LAPW) method within density functional theory. Energy gap obtained for the case is 6.1 eV and it is wide band insulator. Keywords— Band gap, density of state, energy bands, perovskite, insulator.
The Impact of School Culture on Serbian Primary Teachers ’ Job Satisfaction

This paper presents the results of research into the impact of school culture on teacher job satisfaction. The participants were 362 teachers from 57 primary schools in Serbia. Three dimensions of school culture (Teacher Professionalism and Goal Setting, Professional Treatment by the Administration, Teacher Collaboration) and nine dimensions of job satisfaction (Pay, Promotion, Supervision, Fringe Benefits, Contingent Rewards, Operating Procedures, Co-Workers, Nature of Work, Communication) were measured. The results indicate that all three dimensions of school culture are directly related to the job satisfaction of teachers in primary schools in Serbia, but that Professional Treatment by the Administration has the strongest influence. The teachers’ gender and age were used as moderators of the relationship between the school culture dimensions and the job satisfaction dimensions. The results of hierarchical regression analysis show that the moderating effect of gender has been confirmed in two dimensions of job satisfaction: Fringe Benefits and Operating Procedures, while the moderating effect of age can be seen in four dimensions of job satisfaction: Fringe Benefits, Operating Procedures, Co-Workers and Communication. School culture has been shown to influence primary teachers’ job satisfaction. Considering that school culture can be improved, it is possible to improve teachers’ job satisfaction as well.
Identification of a novel S 6 K 1 splice variant coding for the p 60S 6 K 1 isoform

I. V. Zaiets, V. V. Holiar, V. V. Filonenko © 2019 I. V. Zaiets et al.; Published by the Institute of Molecular Biology and Genetics, NAS of Ukraine on behalf of Biopolymers and Cell. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited UDC 577