Miracle-dz/UniFAR-FTUs huggingface dataset:
Follow-Up of Pathological Stage I and IIA Supradiaphragmatic Hodgkin's Disease Primarily Treated with Radiotherapy

One hundred and fifty-five consecutive previously untreated adult patients with supradiaphragmatic pathologic stage IA (71) and IIA (84) Hodgkin's disease treated only with radiotherapy (RT) at the Istituto Nazionale Tumori of Milano from 1970 to 1978 were reviewed. Staging procedures included lymphangiography and laparotomy in all cases. Most patients were irradiated with a conventional cobalt machine. Mantle fields were adopted for 36.8% of cases, mainly at stage I, whereas 63.2% received mantle plus paraaortal irradiation. Doses were above 40 Gy for involved sites and 35–40 Gy for prophylactically irradiated nodes. Minimum and median follow-up were 30 months and 6 years, respectively. All patients achieved complete remission at the end of RT. As of June 1981, 89 of 155 patients (57.5%) were alive and free from progression, 60.6% at stage I, and 54.8% at stage II. Relapses occurred in 54 of 155 cases (35%) after a median free interval of 21 months. Marginal recurrences accounted for 5.8%, true recurrences for 9%, nodal extensions for 8.4%, and extranodal extensions for 11.6%. Males older than 40 years and mediastinal involvement were correlated with higher relapse rates. Salvage treatment consisted of RT alone in 8 patients and chemotherapy plus or minus RT in 44, whereas 2 patients died before a new treatment could start. As of June 1981, 38 of 54 relapsed patients (70.4%) were alive and disease free, whereas 2 were alive with evidence of disease. Actuarial overall survival at 6 years was 90.3% for all cases, 97.1% for stage I, and 84.8% for stage II. Treatment toxicity was analyzed, and problems concerning surgical staging procedures, optimal RT and role of chemotherapy as primary or salvage treatment were discussed.
Combined therapy with PJ34, a poly(ADP‐ribose)polymerase inhibitor, reduces tissue plasminogen activator‐induced hemorrhagic transformations in cerebral ischemia in mice

Recombinant tissue‐type plasminogen activator (rt‐PA) is presently the only pharmacological treatment approved for thrombolysis in patients suffering from ischemic stroke. Although reperfusion of ischemic tissue is essential, the use of rt‐PA is limited due to its narrow therapeutic window and risk of hemorrhagic transformations. Recent studies have shown that rt‐PA amplifies the post‐ischemic activation of the nuclear enzyme poly(ADP‐ribose)polymerase (PARP). This enzyme has been shown to contribute to both the breakdown of the blood brain barrier and spontaneous hemorrhagic transformations after ischemia. We therefore examined the capacity of PJ34 (N‐(6‐oxo‐5,6‐dihydrophenanthridin‐2‐yl)‐2‐(N,N‐dimethylamino) acetamide hydrochloride), a potent inhibitor of PARP, to reduce the hemorrhagic transformations that occur after rt‐PA in mice with permanent focal cerebral ischemia. Ischemia was produced by intraluminal occlusion of the left middle cerebral artery and treated with vehicle, rt‐PA (10 mg/kg, i.v., 6 h after occlusion) or rt‐PA plus PJ34 (3, 6 or 12 mg/kg, i.p., at ischemia onset and 4 h later). Hemorrhagic transformations, neurological examination, and infarct volumes were evaluated 48 h after the onset of ischemia. Delayed administration of rt‐PA resulted in increased hemorrhagic transformations and aggravated the neurological deficit. Giving PJ34 (3 mg/kg) markedly reduced the hemorrhagic transformations, an effect not owing to a modification of matrix metalloprotease activity. Furthermore, PJ34 improved the neurological functions of rt‐PA‐treated ischemic mice. To conclude, the PARP inhibitor PJ34 makes rt‐PA safer in experimental ischemic stroke.
Is the proof of the pudding in the eating? » - Comparaison entre l’Alternative Investment Market et Alternext

En matiere d'organisation boursiere dediee aux petites et moyennes entreprises (PME), lesucces de l'Alternative Investment Market (AIM) aurait etabli ce segment du London Stock Exchange comme le benchmark, dont l'Alternext serait une declinaison manquee. Cet article tend a infirmer cette proposition. D'abord, la performance d'Alternext (2005-2012) est moins mauvaise que ce qu'ont pu faire accroire les critiques formulees, notamment lorsqu'on la compare a celle de l'AIM au meme stade de developpement. Ensuite, les caracteristiques de l'AIM ne permettent pas de l'eriger en modele d'organisation boursiere dediee aux entreprises moyennes ou petites : le succes semble se fonder moins sur les services que l'AIM fournit a des societes modestes ou innovantes que sur l'arbitrage reglementaire qu'accomplissent des capitalisations assez importantes. Ce constat pose avec acuite la question de la nature et de l'organisation d'un marche boursier adapte aux specificites des PME.
Conformational switches in the VPAC1 receptor

The vasoactive intestinal peptide receptor 1 (VPAC1) belongs to family B of GPCRs and is activated upon binding of vasoactive intestinal peptide (VIP) and pituitary AC‐activating polypeptide neuropeptides. Widely distributed throughout body, VPAC1 plays important regulatory roles in human physiology and physiopathology. Like most members of the GPCR‐B family, VPAC1 receptor is predicted to follow the actual paradigm of a common ‘two‐domain’ model of natural ligand action. However the precise structural basis for ligand binding, receptor activation and signal transduction are still incompletely understood due in part to the absence of X‐ray crystal structure of the whole receptor and to significant structural differences with the most extensively studied family of receptor, the GPCR‐A/rhodopsin family. Here, we try to summarize the current knowledge of the molecular mechanisms involved in VPAC1 receptor activation and signal transduction. This includes search for amino acids involved in the two‐step process of VIP binding, in the stabilization of VPAC1 inactive and active conformations, and in binding and activation of G proteins.
An empirical study of online shopping customer satisfaction in China: a holistic perspective

Purpose – The purpose of this study is to identify factors that may influence Chinese customers' online shopping satisfaction, including those which are ignored by prior studies, from the perspective of total online shopping experience.Design/methodology/approach – In this paper, the authors propose a model of the satisfaction process in the e‐commerce environment, identifying key constructs proposed by prior studies and developing hypotheses about which dimensions of online retailer constructs are significant predictors of online shopper satisfaction. The authors test the hypotheses through multiple regression analysis based on a survey of 1,001 online customers.Findings – The analysis suggests that eight constructs – information quality, web site design, merchandise attributes, transaction capability, security/privacy, payment, delivery, and customer service – are strongly predictive of online shopping customer satisfaction, while the effect of response time is not significant.Research limitations/impli.
A Temporal Model of Vertical Relationships

Purpose: The authors developed a model framework for buyer–supplier relationships and used it to extend theory in 4 areas: (a) maintenance of long-term relationships; (b) conversion of relationships from adversarial to cooperative; (c) changes in relationships over their lives; and (d) levels of commitment and trust between partners. Methodology/approach: The authors analyzed existing research on buyer–seller relationships and theoretical concepts in various disciplines to develop a 3-stage temporal relationship model consisting of pre-deal (t–1), deal enactment (t), and deal continuation (t+1) stages. From the model and existing research, the authors drew propositions for relationships in the areas of buyer and seller power, several forms of commitment and trust, intellectual capital, and financial performance. Findings: Briefly, the authors proposed that (a) at the pre-deal stage, increased buyer power may instigate supplier input commitment or vice versa; (b) at deal enactment, both parties may commit to a written contract and build contractual trust through a low degree of relational commitment; and (c) in the deal continuation stage, contractual trust, and attitudinal commitment of one of the parties is likely to foster attitudinal commitment in the other party. The authors found that buyer's and supplier's total commitment fosters goodwill trust and helps build intellectual capital and financial performance, and that the weaker party in the relationship likely gains more from the partnership than the stronger party. Research implications: In addition to existing research, the authors used several actual situations to provide support for our propositions. However, more research should be done in all areas to additionally confirm our propositions and otherwise add to theory development. Practical implications: By looking at buyer–seller relationships in three stages, the authors developed several implications for both parties. These included long-term results of short-term actions, importance of industry factors on buyer and seller commitment, and the role of commitment in determining whether long-term relationships are developed. Originality/value/contribution: The authors extended and coordinated existing theory by consolidating the implications of previous research into a cohesive buyer–supplier relationship model. This model should enable both researchers and managers to better comprehend the dynamics of vertical relationships with a multi-dimensional, reciprocal approach. The results should also provide managers an additional tool to gauge and forecast the fate of a relationship by analyzing levels of trust and commitment as the relationship progresses.
Asymmetrical slit Si waveguide TE-TM mode converter

An asymmetrical slit waveguide TE-TM mode converter is investigated for integrating with a Si waveguide optical isolator. We fabricated the mode converter of which structure is compatible with a Si Mach-Zehnder interferometer waveguide optical isolator. A TE-TM mode conversion of 89% was measured at a wavelength of 1.55 μm in the device with 8-μm-long slit.
Comparison of Wastewater Treatment using Activated Carbon from Bamboo and Oil Palm: An Overview

Developing country causes growth of industries sectors. Despite that industrial sectors releases massive amount of waste water into the environment. At the same time, the increasing number of vehicles in Malaysia promotes the development of automobile workshop that produces huge amount of wastewater as well. Wastewater contains high level of suspended total solids and leave untreated. For instance oil, grease, dyestuff, chromium, phosphate in washing products and colouring, as well as heavy metals such as lead, cadmium, barium and others potential metals. All these hazardous wastes directly pollute the environment especially the groundwater and harm the ecosystem. In order to minimize and reduce the impact to the environment, the wastewater needed to be treated using technology such as permeable reactive barrier (PRB). Activated carbon is one of the PRB utilised. It is a compromised material for treatment of wastewater where there are varieties of sources to produce activated carbon. Malaysia as an active agricultural country, massive amount of agriculture wastes can be turned into activated carbon. They are two methods used to produce activated carbon, namely furnace heat processing and microwave processing. The usage of furnace and microwave instruments can produce different quality of activated carbon due to different mechanism involves. Furnace heat processing transferred the heat from external to the internal but microwave processing is vice versa. In this article, a brief overview of activated carbon usage for wastewater treatment is highlighted.
The Mechanism of Inactivation of Human Platelet Factor Va from Normal and Activated Protein C-resistant Individuals (*)

The inactivation of human platelet factor Va by activated protein C (APC) was analyzed by functional assessment of cofactor activity and Western blotting analysis to visualize the factor Va fragments accompanying proteolysis. Platelets were treated with thrombin to facilitate both their activation as well as the release and further activation of platelet factor Va, followed by APC addition. The rates of inactivation were donor-dependent such that 15-60% of the initial cofactor activity was lost within 5 min of APC addition with as much as 10-20% of the activity still remaining after 2 h of incubation. Western blot analysis using a monoclonal antibody that recognizes an epitope between amino acid residues 307 and 506 of the factor V molecule suggested that the factor Va activity resistant to APC inactivation was due to residual heavy chain. Furthermore, in contrast to studies with normal plasma-derived factor Va, two possible cleavage mechanisms could explain the platelet factor Va fragments observed. APC can cleave platelet factor Va initially at Arg, with subsequent cleavages occurring at Arg and Arg. Alternatively, APC can cleave at Arg initially, with further cleavage at Arg then at Arg or at Arg followed by cleavage at Arg. Similar results were obtained if platelets were removed from the inactivation mixtures and phospholipid vesicles were used to supply the membrane surface required for inactivation, suggesting that the order of platelet factor Va peptide bond cleavage or the amount of cofactor activity remaining was not altered by either of these surfaces. Thus, APC is unable to effect the complete inactivation of platelet factor Va, even though it would appear that the same cleavages which render the plasma cofactor inactive are occurring in the platelet cofactor. Analogous protocols were used to study an individual heterozygous for the Arg Gln mutation (Factor V Leiden, Factor V). With respect to the mutant platelet factor Va in the presence of APC, >70% of the initial cofactor activity remained after 1 min, with 30% activity still remaining after 2 h. As seen in studies of the APC-catalyzed inactivation of plasma factor Va, proteolysis of the mutant platelet factor Va confirms that even though cleavage at Arg will occur in the absence of cleavage at Arg, the rate of inactivation is slower. Collectively these data suggest that when compared to normal plasma factor Va, differences in normal platelet factor Va which define: 1) whether the heavy chain is susceptible to cleavage at Arg or Arg and 2) the extent to which it is cleaved initially at Arg, in contrast to cleavage of Arg, will define both the extent and rate of inactivation.
Evaluating Empirical Research into Music in Advertising: A Congruity Perspective

ABSTRACT This research provides a review and analysis of empirical studies focusing upon cognitive and affective response to music in advertising. It draws together an apparently disparate literature to reach conclusions that will be valuable to advertising practitioners and academics. Findings are categorized by introducing 10 original definitions of music/advertising congruity (score, mood, repetition, association, valence, semantic, genre, image, tempo, and timbre). This highlights the emergence of a coherent pattern in which increased music/advertising congruity contributes synergistically to communications effectiveness by enhancing purchase intent, brand attitude, recall facilitation, and affective response. However, additional evidence indicates that future research should assess the benefits of using more artfully incongruous musical stimuli.
Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts.

In addition to acyl-CoA, purified glycerol-3-phosphate acyltransferases from pea and spinach chloroplasts can also use acyl-(acyl-carrier protein), acyl-ACP, as a substrate for glycerol 3-phosphate acylation. The enzyme fractions showed absolute specificity for glycerol 3-phosphate as acyl acceptor. Dihydroxyacetone phosphate was ineffective. Glycerol 3-phosphate was almost exclusively acylated at the C-1 position. If mixtures of palmitoyl-ACP, stearoyl-ACP and oleoyl-ACP were offered, the oleoyl group was preferred. These data fully agree with previous experiments on these enzymes carried out with various acyl-CoA thioesters. Kinetic data determined with different acyl-ACPs as substrates are consistent with the observed fatty acid selectivity for the oleoyl group. Double labelling experiments with mixtures of oleoyl-ACP and oleoyl-CoA demonstrated a preference for ACP-thioesters. Monoacylglycerol-3-phosphate acyltransferase, localized in the envelope of chloroplasts, can also utilize acyl-ACP as substrate. Envelope fractions of spinach as well as of pea showed a high specificity for the palmitoyl group when ACP-thioesters or CoA-thioesters were offered and directed this acyl group to the C-2 position of the glycerol backbone. Results from competition experiments with [14C]palmitoyl-ACP and [3H]palmitoyl-CoA indicate that the membrane-bound acyltransferase preferably uses ACP-thioesters for the acylation of 1-acylglycerol 3-phosphate. According to fatty acid selectivities and specificities the main product of the recombined acyltransferase systems in chloroplasts of 16:3 plants as well as 18:3 plants is a phosphatidic acid with the oleoyl group at C-1 and the palmitoyl group at C-2 whereas molecules with the oleoyl group at both positions are not synthesized. Under appropriate conditions the phosphatidic acid formed by the soluble acyltransferase and spinach envelope was rapidly converted to monogalactosyl diacylglycerol in the presence of UDP-galactose. In analogous assays with acyltransferase and envelope from pea only a low proportion of labelled phosphatidic acid was converted via diacylglycerol to monogalactosyl diacylglycerol. In both systems monogalactosyl diacylglycerol synthesized in the presence of C16:0-thioesters and C18:1-thioesters carried C18:1 at C-1 and C16:0 at C-2 in agreement with the fatty acid selectivity of the acyltransferase systems.
The personal characteristics of happiness: An EEG study

Previous studies have indicated that the level of happiness associated with various life domains, for example, have reported measuring well-being by Gross National Happiness (GNH). However, during the past two decades, most studies have employed questionnaires to measure the GNH index. This study investigated the level of happiness in neural correlates of individuals by using coherence analysis of EEG data. Twenty healthy volunteers (men) participated in this study, and the mean age of the participants was 20.0 ± 2.0 years. The results showed that greater than little coherent connections were associated with higher levels of happiness. In conclusion, the EEG measures appear to be an effective tool for personal characteristics of happiness.
ACCEPTANCE AND USAGE OF EXTENSIBLE BUSINESS REPORTING LANGUAGE: AN EMPIRICAL REVIEW

Extensible Business Reporting Language (XBRL) is a language based on XML that provides an effective solution for the preparation, presentation and exchange of International Financial Reporting Standards. Many researchers examined the adoption, acceptance or usage of XBRL but none have clarified a direct link between the acceptance of technology and how it affects XBRL users. So, a significant issue to answer is: What is the level of acceptance of XBRL in the European region? Particularly, a new acceptance model was developed based on Technology Acceptance Model 2 (TAM2) in order to test XBRL usage and its impact with five major constructs. The sample consists of 100 listed companies from European Union countries such as United Kingdom, Germany, Spain, Italy, France, Denmark, The Netherlands, Switzerland, Belgium, Luxemburg and Poland. The results reveal that a great number of companies in the European Union are satisfied with the output and the perspectives of XBRL acceptance and usage. The above argument is supported by the positive correlation found in this research among independent constructs and the dependent factors of XBRL acceptance and usage. Europe appears to be a strong supporter of XBRL technology, so non adopters of XBRL can use the results of this study and decide whether XBRL is a useful tool for them or not.
Endogenous nociceptin/orphanin‐fq in the dorsal hippocampus facilitates despair‐related behavior

Nociceptin/orphanin‐FQ (N/OFQ) peptide and its receptor (NOP: N/OFQ opioid peptide receptor) are highly expressed in the hippocampus, but their functional role remains poorly understood. We recently showed that hippocampal N/OFQ inhibits learning and memory abilities in mice. Here, we investigated whether the endogenous peptide also regulated emotional responses at the level of the hippocampus. Bilateral infusions of the selective NOP receptor antagonist, UFP‐101 (1–3 nmol/side), into the dorsal hippocampus produced antidepressant‐like effects in the mouse forced swim and tail suspension tests comparable with those obtained with the prototypical antidepressant, fluoxetine (10–30 mg/kg, intraperitoneal). In the light‐dark test, neither UFP‐101 (1–3 nmol/side) nor N/OFQ peptide (1–3 nmol/side) modified anxiety measures when injected at behaviorally active doses in the dorsal hippocampus. These findings show a clear dissociation in the involvement of hippocampal N/OFQ system in anxiety‐ and despair‐related behaviors. We conclude that the dorsal hippocampus is a brain region in which there is an important N/OFQ modulation of mnemonic processes and adaptive emotional responses associated to despair states. © 2010 Wiley‐Liss, Inc.
Development of genomic GMACE

The use of genomics to enhance national genetic evaluation systems of dairy cattle is quickly becoming standard practice. The current MACE procedure used by Interbull may not accommodate these new “genomically-enhanced” national evaluations. An important assumption in MACE may no longer be valid in the genomics era, the assumption that national evaluations used as input were derived from independent data sets. Genomic predictions are limited by the amount of data currently available within individual countries. Groups of countries may share data, genotypes and/or predicted marker effects to improve genomic predictions, and this will create the need for a modified MACE system, which can account for non-zero residual correlations among genomic predictions from these countries. A system modified for genomics (GMACE) is presented with examples and preliminary results from an application to simulated Brown Swiss data for 9 countries.