Miracle-dz/UniFAR-FTUs huggingface dataset:
Pathologic Outcomes in Men with Low-risk Prostate Cancer Who Are Potential Candidates for Contemporary, Active Surveillance Protocols

The purpose of this study was to determine whether contemporary active surveillance (AS) protocols could sufficiently discriminate significant from indolent tumors in men with low-risk prostate cancer. We retrospectively analyzed 312 patients with low-risk prostate cancer treated with radical prostatectomy. After exclusion of patients with fewer than 10 cores taken at biopsy and those who received neo-adjuvant treatment, 205 subjects satisfied the final inclusion criteria. Five widely accepted AS protocols were employed in this study. A total of 82.0% of the patients met the inclusion criteria of at least one protocol, and 18% did not meet any criteria of published AS protocols. A significant proportion of patients had non-organ-confined disease (8.6% to 10.6%) or a Gleason score of 7 or greater (18.6% to 23.9%) between the different AS criteria. Among patients who did not meet any AS criteria, 32.4% of patients had a pathologically insignificant cancer. Our results indicated a significant adverse pathology in patients who met the contemporary AS protocols. On the other hand, some patients in whom expectant management would be appropriate did not meet any criteria of published AS protocols. None of the clinical or histological criteria reported to date is able to sufficiently discriminate aggressive tumors from indolent ones. Graphical Abstract
Severe alpha1-antitrypsin deficiency (PiZ homozygosity) with membranoproliferative glomerulonephritis and nephrotic syndrome, reversible after orthotopic liver transplantation.

BACKGROUND/AIMS Nephropathy associated with alpha1-antitrypsin deficiency is assumed to be an unusual entity. We describe the case of a 23-year-old woman with severe alpha1-antitrypsin (PiZ homozygosity) deficiency who developed hepatic cirrhosis in childhood, and glomerulonephritis and nephrotic syndrome in adult life. METHODS/RESULTS A renal biopsy was consistent with membranoproliferative glomerulonephritis. An immunofluorescence study revealed the presence of alpha1-antitrypsin (PiZ) in the subendothelial region of the glomerular basement membrane. The renal disease was reversible after orthotopic liver transplantation. CONCLUSIONS The presence of abnormal PiZ protein in the subendothelial region of the glomerular basement membrane may suggest a possible role for this protein in the pathogenesis of glomerulonephritis. The case should add impetus to the search for alpha1-antitrypsin deficiency in any patient presenting with combined liver and renal disease, in the absence of evidence of hepato-renal syndrome, and illustrates that liver transplantation alone may reverse the nephropathy associated with alpha1-antitrypsin deficiency.
Receptor model source attributions for Utah's Salt Lake City airshed and the impacts of wintertime secondary ammonium nitrate and ammonium chloride aerosol

Communities along Utah's Wasatch Front are currently developing strategies to reduce daily average PM2.5 levels to below National Ambient Air Quality Standards during wintertime persistent stable atmospheric conditions, or cold-air pools. Speciated PM2.5 data from the Wasatch Front airshed indicate that wintertime exceedances of the PM2.5 standard are mainly driven by high levels of ammonium nitrate. Stable wintertime conditions foster the formation of ammonium nitrate aerosol when sufficient sources of NOx, ammonia, and oxidative capacity exist. However, this work demonstrates that secondary ammonium chloride aerosol can also be a significant source of secondary wintertime PM2.5 if sufficient sources of atmospheric chlorine exist. Two factor analysis techniques, positive matrix factorization (PMF) and Unmix, were used to identify contributors to PM2.5 at three monitoring stations along Utah's Wasatch Front: Bountiful, Lindon, and Salt Lake City. The monitoring data included chemically speciated PM2.5 data for 227, 227, and 429 days at each location, respectively, during the period from May 2007 through May 2011. PMF identified 10–12 factors and Unmix identified 4–5 factors for each of the locations. The wintertime PMF and Unmix results showed large contributions from secondary PM2.5 when PM2.5 concentrations exceeded 20 μg/m3. PMF identified both ammonium nitrate and ammonium chloride aerosol as significant secondary contributors to PM2.5 (10–15% of total PM2.5 from ammonium chloride) during wintertime pollution episodes. Subsequent ion balance analysis of the monitoring data confirmed the presence of significant ammonium chloride aerosol on these highly polluted days at all three monitoring sites. The directly emitted primary PM2.5 portions of the source attribution results were further compared to county-level emissions inventories and showed generally good agreement for Salt Lake City and Lindon during wintertime except for wood smoke and fugitive dust, which have higher contributions in the receptor modeling results than in the emissions inventories. Implications: The study suggests that secondary ammonium chloride aerosol can be a significant source of wintertime PM2.5 in an ammonia-rich environment, like the Wasatch Front airshed, if sufficient sources of atmospheric chlorine exist. During wintertime, cold-air-pool events, the source attribution results generally agree with the county emission inventories with the exception of wood smoke and cooking sources. At the Salt Lake City monitoring station, the estimated contributions from wood smoke and cooking are nearly double those of the corresponding inventory, suggesting that they are nearly as important as gasoline emissions.
Roles of the hepcidin–ferroportin axis and iron in cancer

Hepcidin is a low-molecular-weight hepatic peptide that regulates iron homeostasis, and acts by causing the degradation of its receptor, the cellular iron exporter ferroportin. On the basis of the major role of the hepcidin–ferroportin axis in iron regulation, recently several studies have discussed its expression and influence on the development and prognosis of cancer. Iron plays a pivotal role in homeostasis. However, insights into the mechanisms of normal iron regulation have provided a new perspective on the basic mechanisms, biological rationale, and pathophysiologic implications of changes in iron metabolism in cancer. Besides being a crucial stimulus for cancer, iron dysfunction also causes cancer-related anemia. In this review, we discuss aspects of the hepcidin–ferroportin axis and iron regulation, as well as the inherent connections between them in cancer. We also attempt to consider the possibility in theory of novel targets for further individualized therapy. However, many molecular mechanisms and functions of these regulators remain unclear.
The Challenges of Efficiency and Security of International Food Value Chains

The paper identifies the main challenges the regulators face while improving efficiency and security of the food value chains. Author found that efficiency and added value at various levels of international food value chain are different, hence it is advisable to analyse each chain level separately. Supported by the efficiency oriented perspective for security of international food value chains, author argues that it enables, on the one hand, to reduce the specific consumption of natural resources and, on the other hand, to decrease prices for finished food products, making them accessible to most part of society. The paper also contains the guidelines for scholars, regulators and food business, who wish to improve the efficiency and security of the food value chains and looking for appropriate way and tools.
Need for uniqueness as antecedents to purchase behaviour amongst Indian youth PAPER RETRACTED

In the developing countries there has been a transition in social values and aspirations of the consumers. This may be attributed to changing lifestyles due to globalisation and awareness about self. Our research was targeted for measuring need for uniqueness (NFU) in Indian youth and their attitudes towards purchase of luxury brand as their expression of individuality. Our research findings suggest that Indian youth did not exhibit high NFU however; luxury brands for them do connote status and expression of individuality. The Indian social system has been witnessing an evolution from traditional family centric values towards more of individual-centric values, thus the trait of NFU and expression of self-identity amongst Indian youth may become more prominent in the future. While marketing global luxury brands in India, advertising may play a major role for creating and conveying a new identity to the consumers while maintaining a balance with traditional family value systems.
Retrovirally Mediated Transfer of a G Protein-coupled Receptor Kinase (GRK) Dominant-negative Mutant Enhances Endogenous Calcitonin Receptor Signaling in Chinese Hamster Ovary Cells

G protein-coupled receptor kinases (GRKs) initiate pathways leading to agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. However, the role of GRKs in modulation of signaling properties of native receptors has not been clearly defined. Here we addressed this question by generating Chinese hamster ovary (CHO) cells stably expressing a dominant-negative mutant of GRK2 (DN-GRK2), K220R, using retrovirally mediated gene transfer, and we assessed function of the endogenously expressed calcitonin (CT) receptors. We found that CT-mediated responses were prominently enhanced in CHO cells expressing DN-GRK2 compared with mock-infected control CHO cells with ∼3-fold increases in CT-promoted cAMP production in whole cells and adenylyl cyclase activity in membrane fractions. CT-promoted phosphoinositide hydrolysis was also enhanced in DN-GRK2 cells. The number of CT receptors was increased ∼3-fold in DN-GRK2 cells, as assessed by125I-salmon CT-specific binding, and this was associated with increased CT receptor mRNA levels. These results indicate that DN-GRK2 has multiple consequences for CT receptor signaling, but a primary effect is an increase in CT receptor mRNA and receptor number and, in turn, enhanced CT receptor signaling. As such, our findings provide a mechanistic basis for previous observations regarding agonist-promoted down-regulation of CT receptors and for resistance and escape from response to CT in vitroand in vivo. Moreover, the data suggest that blunting of receptor desensitization by DN-GRK2 blocks a GRK-mediated tonic inhibition of CT receptor expression and response. We speculate that GRKs play a similar role for other G protein-coupled receptors as well.
Urban Wastewater Management in the United States: Past, Present, and Future

as either centralized, where all the wastewater is collected and conveyed to a central location for treatment or disposal, or decentralized, where the wastewater is primarily treated or disposed of on-site or near the source. Historically, municipalities, consulting engineers, and individuals have had the option of centralized or decentralized wastewater management and could have chosen from a variety of collection and disposal technologies to implement the management strategy. Although these options were available, the majority of engineers, public health officials, policy makers, and members of the public typically preferred one management strategy and one technology to the others. The reasons for a particular preference were based on a combination of cost, urban development patterns, accepted scientific theories, tradition, religious attitudes, prevailing public opinion on sanitation, the contemporary political environment, and many other factors. The development of urban wastewater management strategies and technologies from the early nineteenth century to the present
Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate

Background Individuals with non syndromic cleft lip with or without cleft palate (NSCL±P) present high frequency of dental anomalies, which may represent complicating factors for dental treatment. The aim of this study was to investigate the prevalence of dental anomalies inside cleft area in a group of Brazilians with NSCL±P. Material and Methods Retrospective analysis of 178 panoramic radiographs of patients aged from 12 to 45 years old and without history of tooth extraction or orthodontic treatment was performed. Association between cleft type and the prevalence of dental anomalies was assessed by chi-square test with a significance level set at p≤ 0.05. Results Dental anomalies were found in 88.2% (n=157) of the patients. Tooth agenesis (47.1%), giroversion (20%) and microdontia (15.5%) were the most common anomalies. Individuals with unilateral complete cleft lip and palate (CLP, p<0.0001), bilateral complete CLP (p=0.0002) and bilateral incomplete CLP (p< 0.0001) were more affected by tooth agenesis than individuals with other cleft types. The maxillary lateral incisors were the most affected teeth (p<0.0001). Conclusions The present study revealed a high frequency of dental anomalies inside cleft region in NSCL±P patients, and further demonstrated that patients with unilateral complete CLP and bilateral incomplete CLP were frequently more affected by dental anomalies. Moreover, our results demonstrate that dental anomalies should be considered during dental treatment planning of individuals affected by NSCL±P. Key words:Nonsyndromic cleft lip with or without palate, dental anomaly, tooth agenesis, microdontia.
Integrating MR imaging into the clinical workup of pregnant patients suspected of having appendicitis is associated with a lower negative laparotomy rate: single-institution study.

PURPOSE To determine if integrating magnetic resonance (MR) imaging into the workup of right lower quadrant pain in pregnant patients was associated with improved outcomes as measured by the negative laparotomy rate (NLR) and the perforation rate (PR). MATERIALS AND METHODS Institutional review board approval was obtained for this retrospective review of medical records. Two hundred sixty-seven pregnant patients who underwent either surgery (n = 82) or an MR imaging examination (n = 217) because of suspicion of appendicitis between January 1, 1996, and August 31, 2011, were identified. Relevant ultrasonographic and MR imaging reports were classified as showing true-positive, false-positive, true-negative, false-negative, or equivocal findings. MR imaging utilization was analyzed to define pre- and post-MR imaging cohorts. NLR and PR were calculated for both cohorts and were compared by using a Fisher exact probability test. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for MR imaging were calculated. RESULTS MR imaging was introduced into the clinical workup in 2004. From 1996 to 2003, the NLR for pregnant patients was 55% (17 of 31), and the PR was 21% (three of 14). From 2004 to 2011, the NLR was 29% (15 of 51), and the PR was 26% (nine of 35). The 47% decline in the NLR ([55%-29%]/55%) was statistically significant (P = .02). The change in PR was not significant (P > .99). The sensitivity, specificity, PPV, and NPV of MR imaging in the diagnosis of appendicitis were 89% (17 of 19), 97% (187 of 193), 74% (17 of 23), and 99% (187 of 189), respectively. CONCLUSION The routine incorporation of MR imaging into the clinical workup for suspicion of appendicitis in pregnant patients at this institution was associated with a decrease in the NLR of 47% without a significant change in the PR. SUPPLEMENTAL MATERIAL http://radiology.rsna. org/lookup/suppl/doi:10.1148/radiol.12121027/-/DC1.
Maternal serum soluble fms‐like tyrosine kinase‐1 at 12, 22, 32 and 36 weeks' gestation in screening for pre‐eclampsia

To examine the distribution of maternal serum soluble fms‐like tyrosine kinase‐1 (sFlt‐1) at 12, 22, 32 and 36 weeks' gestation in singleton pregnancies that develop pre‐eclampsia (PE) and examine the performance of this biomarker in screening for PE.
Corneal topographic and pachymetric screening of keratorefractive patients.

PURPOSE To review the incidence of corneal abnormalities detected in the preoperative examination, using videokeratography and pachymetry that excluded patients from laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK). METHODS We conducted a chart review of consecutive patients who had a preoperative examination and were excluded from refractive surgery. RESULTS Eighteen patients from 1,392 refractive candidates (1.3%) were designated as poor candidates for LASIK or PRK based on corneal topography and/or pachymetry. Thirteen patients (0.9%) were identified as having keratoconus suspect, keratoconus, or pellucid marginal degeneration. Five patients (0.4%) were excluded due to thin corneas (<490 microm) despite normal corneal topography. CONCLUSIONS Corneal topography and pachymetry are indispensable tools in the preoperative screening of refractive surgery candidates.
Arabinoxylans and Arabinogalactans: A Comprehensive Treatise

The functional and nutraceutical importance of various foods is often attributed to the bioactive molecules present in them. A number of components have been studied but dietary fiber and its different constituents are of prime consideration. Among these, arabinoxylan (AX) and arabinogalactan (AG) are of significant importance in that they hold potential in improving the quality of the baked products along with providing health benefits against various ailments. However, the improvements are dependent on their molecular weights, cross linkages, and solubility. Water-Extractable Arabinoxylan (WEAX) is more effective as compared to Water-Unextractable Arabinoxylan (WUEAX). In this review article, efforts were directed to describe the structural and molecular conformations of these functional ingredients. The discussion has been made regarding the functional properties of AX and AG, for example, improvements in water absorption capacities, dough stability time, and viscosity. They also improve the baking absorption of flour that is positively correlated with bread volume, the most important criterion for stakeholders. The arguments are also provided on the detrimental effects on gluten quality with some possible solutions. Their role in improving the quality and extending the shelf life of bread by reducing the process of staling and retrogradation is the main idea presented in the article. The nutraceutical perspectives were also highlighted as they are helpful in regulating blood cholesterol which thereby protect the body from cardiovascular disorders like atherosclerosis. Additionally, they act as prebiotics for microorganisms residing in the gastrointestinal tract.
Regulating International Finance: The Genesis and Transformation of Central Banking Practices

This dissertation investigates the development of f inancial regulation since the nineteenth century through central banks’ governing practices in indus trial countries. Since central banks adopted the lender-of-last-resort function in the 1870s, th ey ave been continuously contributing to the stabilization of financial markets. However, the na ture of their governing practices has transformed. This dissertation addresses the sociol ogical and historical underpinnings of central banks’ authority. By combining theoretical insights from interactionist sociology (e.g., Pierre Bourdieu, Norbert Elias, and Etienne Wenger) and fr om the philosophy of modernity (e.g., Hannah Arendt, Michel Foucault, and Jürgen Habermas ), it looks into the crucial role of knowledge for financial governance in general and c entral banks’ authority in particular. Knowledge shapes governance in two ways. It structu ally creates the conditions of possibility for certain practices to develop and it cognitively represents reality. Such representations become incorporated into the background knowledge of the c ommunity of practice. The thesis highlights the importance of modern science for governance to occur. The rise of science in economics and finance has transformed legitimate representations of the financial environment and concepts of competence and credibility defining who is entitled to act. The dissertation details three practices of financial stabilization by central banks through time, each of which stem from a distinct
Negative behavior during marital conflict is associated with immunological down‐regulation.

&NA; Although increased morbidity and mortality have been reliably associated with social isolation and less satisfying personal relationships, relatively little is known about the underlying biopsychosocial mechanisms. We assessed problem‐solving behaviors and changes in immune function in 90 newlywed couples who were admitted to a hospital research unit for 24 hours. Subjects who exhibited more negative or hostile behaviors during a 30‐minute discussion of marital problems showed greater decrements over 24 hours relative to low negative subjects on four functional immunological assays (natural killer cell lysis, blastogenic response to two mitogens, and the proliferative response to a monoclonal antibody to the T3 receptor), as well as larger increases in the numbers of total T lymphocytes and helper T lymphocytes. High negative subjects had higher antibody titers to latent Epstein‐Barr virus than low negative subjects, consistent with down‐regulated immune function. Women were more likely to show negative immunological changes than men. The discussion of marital problems also led to larger increases in blood pressure that remained elevated longer in high negative subjects than low negative subjects. Positive or supportive problem‐solving behaviors were not related to either immunological or blood pressure changes. These physiological differences were particularly noteworthy because marital satisfaction was high in both groups, and couples had been selected on the basis of stringent mental and physical health criteria. These data provide additional support for the link between personal relationships and immune function.
Validity of Thromboelastometry for Rapid Assessment of Fibrinogen Levels in Heparinized Samples During Cardiac Surgery: A Retrospective, Single-center, Observational Study.

OBJECTIVE To assess the validity of fibrinogen assay of rotational thromboelastometry (FIBTEM)-derived estimates of fibrinogen in samples collected during cardiopulmonary bypass in cardiac surgical patients by comparison to Clauss method fibrinogen concentration. DESIGN Retrospective observational study. SETTING Single university hospital center. PARTICIPANTS Human participants. INTERVENTIONS Retrospectively obtained laboratory assays including rotational thromboelastometry (ROTEM) and Clauss fibrinogen assay. MEASUREMENTS AND MAIN RESULTS A retrospective review was performed of anesthesia records at a single university teaching hospital during a 1-year period. From paired samples taken near the end of cardiopulmonary bypass, fibrinogen concentrations (Clauss method) were compared with FIBTEM-derived measures of maximal clot firmness (MCF) and clot amplitude at 10 minutes (A10) using Spearman's rank correlation, linear regression, and receiver operating characteristic curve analysis. The study included 1,077 patients. Clauss fibrinogen was correlated strongly with FIBTEM amplitudes (r = 0.78 for MCF and A10; p<0.01). The correlation was related inversely to hemoglobin concentration (p<0.01). The area under the receiver operating characteristic curve was 0.95; the optimal FIBTEM A10 cutoff for diagnosis of a fibrinogen concentration of<1.5 g/L was ≤8 mm. CONCLUSIONS The FIBTEM was a valid point-of-care method for estimating the fibrinogen concentration during cardiopulmonary bypass and may be used for prediction of hypofibrinogenemia before separation from the extracorporeal circuit.