Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of the AUU initiation codon in the negative feedback regulation of the gene for translation initiation factor IF3 in Escherichia coli

The expression of the infC gene encoding translation initiation factor IF3 is negatively autoregulated at the level of translation, i.e. the expression of the gene is derepressed in a mutant infC background where the IF3 activity is lower than that of the wild type. The special initiation codon of infC, AUU, has previously been shown to be essential for derepression in vivo. In the present work, we provide evidence that the AUU initiation codon causes derepression by itself, because if the initiation codon of the thrS gene, encoding threonyl‐tRNA synthetase, is changed from AUG to AUU, its expression is also derepressed in an infC mutant background. The same result was obtained with the rpsO gene encoding ribosomal protein S15. We also show that derepression of infCthrS, and rpsO is obtained with other ‘abnormal’ initiation codons such as AUA, AUC, and CUG which initiate with the same low efficiency as AUU, and also with ACG which initiates with an even lower efficiency. Under conditions of IF3 excess, the expression of infC is repressed in the presence of the AUU or other ‘abnormal’ initiation codons. Under the same conditions and with the same set of ‘abnormal’ initiation codons, the repression of thrS and rpsO expression is weaker. This result suggests that the infC message has specific features that render its expression particularly sensitive to excess of IF3. We also studied another peculiarity of the infC message, namely the role of a GC‐rich sequence located immediately downstream of the initiation codon and conserved through evolution. This sequence was proposed to interact with a conserved region in 16S RNA and enhance translation initiation. Unexpectedly, mutating this GC‐rich sequence increases infC expression, indicating that this sequence has no enhancing role. Chemical and enzymatic probing of infC RNA synthesized in vitro indicates that this GC‐rich sequence might pair with another region of the mRNA. On the basis of our in vivo results we propose, as suspected from earlier in vitro results, that IF3 regulates the expression of its own gene by using its ability to differentiate between ‘normal’ and ‘abnormal’ initiation codons.
SCALE: A Scalable Language Engineering Toolkit

In this paper we present SCALE, a new Python toolkit that contains two extensions to n-gram language models. The first extension is a novel technique to model compound words called Semantic Head Mapping (SHM). The second extension, Bag-of-Words Language Modeling (BagLM), bundles popular models such as Latent Semantic Analysis and Continuous Skip-grams. Both extensions scale to large data and allow the integration into first-pass ASR decoding. The toolkit is open source, includes working examples and can be found on http://github.com/jorispelemans/scale.
Estrogenic Activity of Cosmetic Components in Reporter Cell Lines: Parabens, UV Screens, and Musks

In this work, the estrogenic effects of three classes of substances included in cosmetic formulations—parabens, ultraviolet (UV) screens, and musk fragrances—were studied. Their estrogenic activity was measured with the use of three reporter cell lines: HELN, HELN ERα, and HELN ERβ. These three cell lines allowed for the measurement of estrogenic activity toward estrogen receptors α and β (ERα and ERβ), while taking nonspecific interactions into account. Eight of the 15 substances tested showed specific estrogenic activity with the following degree of potency on ERα: butylparaben > propylparaben > homosalate = octyl-dimethyl-PABA = 4-methyl-benzylidenecamphor = octyl-methoxycinnamate > ethylparaben = galaxolide. Among these active substances, parabens activated ERα and ERβ similarly, UV screens activated ERα moderately and had almost no effect on ERβ, and fragrances did not activate ERβ. Methylparaben, ethylparaben, musk moskene, celestolide, and cashmeran did not activate estrogenic responses up to 10−5 M. Musk ketone and benzophenone-3 were not considered estrogenic at 10−5 M. We thank S. Bintein and the MATE, France (Ministère de l’Aménagement du Territoire et de l’Environnement), for financial support. M. Manley, professional translator, improved the English.
DESIGN AND IMPLEMENTATION OF A LOW-VOLTAGE 2.4-GHZ CMOS RF RECEIVER FRONT-END FOR WIRELESS COMMUNICATION

This paper presents the design of a 1.5 V CMOS RF receiver front-end system which contains a low noise amplifier (LNA) with band pass filter and a down conversion mixer. An inter-stage matching network is added between the common-source and common-gate transistors in the LNA’s first stage to further lower the noise and enhance the overall gain. An inductor is used in this inter-stage matching network because of the extra capacitive of MOSFETs in the LNA. The maximum gain achieved of this LNA is 15 dB. The single square-law structure was implemented for this low power consumption and high linearity mixer. From the measured results, the whole receiver provides a conversion gain of 8.5 dB at 2.4 GHz with LO power input -3.5 dBm. The power dissipation of this front-end is 9 mW .
Capture of Target Cell Membrane Components via Trogocytosis Is Triggered by a Selected Set of Surface Molecules on T or B Cells1

Key events of T and B cell biology are regulated through direct interaction with APC or target cells. Trogocytosis is a process whereby CD4+ T, CD8+ T, and B cells capture their specific membrane-bound Ag through the acquisition of plasma membrane fragments from their cellular targets. With the aim of investigating whether the ability to trigger trogocytosis was a selective property of Ag receptors, we set up an assay that allowed us to test the ability of many different cell surface molecules to trigger trogocytosis. On the basis of the analysis of a series of surface molecules on CD4+ T, CD8+ T, and B cells, we conclude that a set of cell type-specific surface determinants, including but not limited to Ag receptors, do trigger trogocytosis. On T cells, these determinants include components of the TCR/CD3 as well as that of coreceptors and of several costimulatory molecules. On B cells, we identified only the BCR and MHC molecules as potentials triggers of trogocytosis. Remarkably, latrunculin, which prevents actin polymerization, impaired trogocytosis by T cells, but not by B cells. This was true even when the same Abs were used to trigger trogocytosis in T or B cells. Altogether, our results indicate that although trogocytosis is performed by all hemopoietic cells tested thus far, both the receptors and the mechanisms involved can differ depending on the lineage of the cell acquiring membrane materials from other cells. This could therefore account for the different biological consequences of Ag capture via trogocytosis proposed for different types of cells.
Analysis of an integrated offshore wind farm and seashore wave farm fed to a power grid through a variable frequency transformer

This paper presents the analyzed results of an integrated offshore wind farm (OWF) and seashore wave farm (WAF) connected to an onshore large power grid through a variable frequency transformer (VFT) to simultaneously achieve power-fluctuation mitigation and stability enhancement. The performance of the studied OWF is simulated by an equivalent aggregated 80-MW doubly-fed induction generator (DFIG) while the characteristics of the studied WAF are simulated by an equivalent aggregated 40-MW squirrel-cage induction generator (SCIG). Steady-state operating conditions of the studied system under various values of wind speed and axial speed are performed. A time-domain scheme based on a nonlinear system model subject to a disturbance condition is also carried out. It can be concluded from the simulation results that the proposed VFT can effectively stabilize the studied hybrid OWF and WAF under various disturbance conditions. The inherent fluctuations of the power injected to the power grid can also be effectively smoothed by the proposed VFT.
Information Technology Implementation Prioritization in Supply Chain: An Integrated Multi Criteria Decision Making Approach

The increasing rate of technology growth has resulted in decrease in cost of information. These technologies are helpful in coordinating the activities resulting in effective management of the supply chain. Literature shows that the use of Information Technology (IT) plays an important role in managing the processes of SCM. This has resulted in increasing use of IT in SCM. The computerization of SCM processes, if implemented in one go may result in failure. IT implementation prioritization in supply chain is a major issue before the planner as there is no clear cut formula to solve this problem. This paper considers components of SCM like material management, purchase management, production management, logistics and distribution and customer interface for IT implementation prioritization. Two multi-criteria decision making methods (MCDM) viz. analytical hierarchy process (AHP) and a technique for order preference by similarity to ideal solution (TOPSIS) are used in this paper. The novelty of the paper lies in integration of AHP and TOPSIS methods for IT implementation prioritization. The weights of the criterions and the alternatives are calculated using AHP method which is used as an input for TOPSIS analysis for prioritization of IT implementation.
Anger-Related Personality Traits and Carotid Artery Atherosclerosis in Untreated Hypertensive Men

Objective: To determine whether anger-related personality traits are associated with carotid artery atherosclerosis in untreated hypertensive patients. Methods: Study participants were 237 men with elevated blood pressure (systolic 140–180 mm Hg and/or diastolic 90–110 mm Hg) but untreated for hypertension. Average age was 56 years; 80% of subjects were white. Eighty-six percent had no history of antihypertensive treatment, and the remainder reported median lifetime treatment exposure of 4 months. Subjects were administered the Spielberger State-Trait Anger Expression Inventory, which measures tendencies to experience anger (Trait Anger) and modes of anger expression (Anger-In, Anger-Out, Anger-Control). Mean and maximum intima-medial thickness (IMT) and plaque occurrence in the extracranial carotid arteries were measured by B-mode ultrasonography. Results: Trait Anger was marginally (p = .065) related to mean and significantly (p < .05) related to maximum IMT, independent of standard risk factors (age, race, body mass index, education, smoking, fasting glucose, total:high-density lipoprotein cholesterol ratio). A component of Trait Anger, Angry Temperament, similarly predicted mean (p = .062) and maximum IMT (p < .05) and plaque occurrence (p < .05). Anger-Out predicted both mean and maximum IMT (p values <.01). Conclusions: An antagonistic disposition (Trait Anger), particularly a tendency to experience anger on minimal provocation (Angry Temperament) and a propensity to express anger outwardly (Anger-Out), are associated with heightened carotid atherosclerosis. These findings suggest that recently reported prospective associations between these anger dimensions and incident cerebrovascular disease may be mediated, in part, by increased atherosclerotic disease. ARIC = Atherosclerosis Risk in Communities; HDL = high-density lipoprotein; IMT = intima-medial thickening; REACT = University of Pittsburgh Reactivity and Cardiovascular Risk Trial; BP = blood pressure; SBP = systolic blood pressure; DBP = diastolic blood pressure; BMI = body mass index.
Mutagenicity of DDT in mice, Drosophila melanogaster and Neurospora crassa.

The pesticide DDT was examined for possible mutagenicity in mice, D. melanogaster and N. crassa. Through the use of the dominant-lethal assay it was found that acute oral doses of DDT (2 x 150 mg/kg body weight) in male mice induced dominant lethal mutations in early spermatid and spermato-cyte stages. Chronic oral doses of DDT (2 x 100 mg/kg body weight per week for 10 weeks) in male mice caused a persistent increase in the number of dominant lethal mutations. Histological sections showed that chronic treatment of mice with DDT caused changes in seminiferous tubule morphology and degeneration of B-type spermatogonia. Acute treatment of mice with DDT caused an increase in spermatocyte chromosome breakage, stickiness and precocious separation of the X and Y bivalent.
Electroencephalography of DSM‐III borderline personality disorder

ABSTRACT– The EEG's of hospitalized males with the sole diagnosis of borderline personality disorder (n= 37) were compared to those of a group with only dysthymic disorder (n= 31). Borderline patients were found to have significantly more marginal, definite, and combined (marginal and definite) abnormalities on the EEG. The most prevalent abnormality in the borderline was slow‐wave activity. The mixture of wave frequencies occurring in the electroencephalogram, known as fusing, occurred significantly more often in the borderline group compared to the dysthymic group. Severity of illness of the borderline group and the depressed group was not significantly correlated with EEG abnormality. Neurophysiologic implications for the pathogenesis of the borderline personality disorder are discussed in light of these findings.
ROSSO-in-praxi: a self-monitoring of blood glucose-structured 12-week lifestyle intervention significantly improves glucometabolic control of patients with type 2 diabetes mellitus.

BACKGROUND As healthy diet and physical activity can improve glucometabolic control in patients with type 2 diabetes, lifestyle changes should be the basis for each therapy. The only tool to visualize immediate effects of food pattern and exercise on blood glucose levels is self-monitoring of blood glucose (SMBG). Therefore, the aim of the 12-week lifestyle intervention ROSSO-in-praxi was to evaluate the impact of an SMBG-structured motivation and education program on glucometabolic and health parameters in diabetes patients not treated with insulin. METHODS Participants (n = 405) generated a seven-point blood glucose diurnal profile every 4 weeks, including actual weight, waist circumference, and steps/day. At baseline and the end of the study, glycated hemoglobin A1c (HbA1c), blood pressure, and cholesterol levels, lifestyle changes, and well-being (SF36 and Center for Epidemiologic Studies Depression Scale questionnaires) were assessed. RESULTS Three hundred twenty-seven participants (81%) completed the program and significantly improved quality of diet and physical activity, accompanied by an increase of >2,300 steps/day. Participants significantly reduced weight, body mass index, waist circumference, blood glucose, blood pressure, low-density lipoprotein cholesterol, and HbA1c by 0.3% (all P < 0.001), accompanied by increased physical and mental health and reduced depression measurements. Weight loss was significantly associated with overall improvements of glucometabolic and health parameters and mean reduction of 0.05% HbA1c/kg. CONCLUSIONS The evaluated SMBG-structured lifestyle intervention is applicable to motivate individuals with type 2 diabetes for lifestyle changes. Integration of this short-term, highly motivational, and low-cost intervention into basic therapy for patients without insulin therapy could strengthen patient empowerment in order to change lifestyle and to improve glucometabolic and general health.
A nested domain decomposition method for simulations of resistivity borehole micro-imaging tool

A nested domain decomposition method is proposed to study the responses of resistivity borehole micro-imaging tools used in the oil and gas exploration industry. The multiscale structure of an imaging problem is decomposed into several nested subdomains based on its geometric characteristics. Each subdomain is discretized independently, and numerical flux is used to couple all subdomains together. The nested domain decomposition scheme will lead to a block tridiagonal linear system, and the block Thomas algorithm is utilized here to eliminate the subdomain based iteration in the step of solving the linear system. Numerical results demonstrate the validity and efficiency of this method.
Online fraud transaction prevention system using extended visual cryptography and QR code

Now a days many people are doing online financial transactions. This transaction needs to be secure. There are various attacks present behind this. Phishing is one type of attack. For detecting this attack, various anti-phishing mechanisms are used. In phishing process, suppose cheater sends out thousands of phishing emails with a link to the fake website. Victims click on links in email believing it is legitimate. They enter personal information on that fake website. Fraudsters collect the stolen data and login into correct website. This is an overall process of phishing. We propose a new scheme for online fraud transaction prevention using extended visual cryptography and QR codes. This scheme uses extended visual cryptography for share generation. One time password is used for phishing website detection. Extended visual cryptography is used for converting the QR code into two shares. The system provides security for online users and detecting the phishing websites.
Noyau de Treelets appliqué aux graphes étiquetés et aux graphes de cycles

La chemoinformatique utilise des methodes issues de l'informatique, plus particulierement la theorie des graphes et l'apprentissage automatique, afin de classifier ou predire les proprietes de bases de molecules. Dans ce contexte, les noyaux sur graphes fournissent une approche interessante en combinant les methodes d'apprentissage automatique et la repre- sentation naturelle des molecules par graphes. Parmi les methodes basees sur les noyaux sur graphes, la decomposition du graphe en sous structures represente une importante famille de noyau. Dans cet article, nous presentons deux extensions d'un noyau precedemment base sur les sous structures non etiquetees a l'enumeration de sous structures etiquetees et a la prise en compte de l'information cyclique des molecules. Nous proposons egalement des methodes de selection de variables permettant de ponderer un ensemble de sous structures afin d'ameliorer la precision de la prediction
Phenotypic and genetic relationships between reproduction and milk production in dairy goats.

First lactations of 3286 Alpine, Nubian, Saanen, and Toggenburg does were used to assess consequences of correcting milk and fat yields for age and season of kidding and to estimate heritabilities and phenotypic and genetic relationships between milk production and reproductive traits. Does were classified into those that reproduced successfully during their first breeding year and those that did not and were held over to the following year before reproducing successfully. Heritabilities of milk and fat yield and fat percent adjusted for age-season were . 68, . 61, and . 54 for Alpines, Saanens, and Toggenburgs and . 35, . 54, and 1.09 for Nubians. Phenotypic and genetic correlations between date of kidding and unadjusted milk and fat yield were negative but were close to zero for adjusted yields. Phenotypic correlations for age of kidding with unadjusted milk and fat yields were positive and with adjusted yields were near zero. Genetic correlations for age at kidding with unadjusted yields were positive but with adjusted yields were negative but small. Selection on unadjusted milk yield of first lactation would lead to fewer reproductive successes during the first breeding year and later ages at kidding, but selection on adjusted yields would result in little correlated change in reproductive performance.
Investigation of factors related to employment outcome following traumatic brain injury: a critical review and conceptual model

Purpose: The purpose of this article is to critically review the literature to examine factors that are most consistently related to employment outcome following traumatic brain injury (TBI), with a particular focus on metacognitive skills. It also aims to develop a conceptual model of factors related to employment outcome. Method: The first stage of the review considered 85 studies published between 1980 and December 2003 which investigated factors associated with employment outcome following TBI. English-language studies were identified through searches of Medline and PsycINFO, as well as manual searches of journals and reference lists. The studies were evaluated and rated by two independent raters (Kappa = 0.835) according to the quality of their methodology based upon nine criteria. Fifty studies met the criteria for inclusion in the second stage of the review, which examined the relationship between a broad range of variables and employment outcome. Results: The factors most consistently associated with employment outcome included pre-injury occupational status, functional status at discharge, global cognitive functioning, perceptual ability, executive functioning, involvement in vocational rehabilitation services and emotional status. Conclusions: A conceptual model is presented which emphasises the importance of metacognitive, emotional and social environment factors for improving employment outcome.
MEDICAL IMAGING COMPUTING BASED ON GRAPHICAL PROCESSING UNITS FOR HIGH PERFORMANCE COMPUTING

The Design of GPU(Graphical Processing Unit) will well suitable for express the data parallel computations because GPU will specialized for parallel and today's digital images in medical are huge volume of collections in every day, however medical imaging produces demand to improve the medical diagnosis and procedures. This survey is provide graphical processing computations and hardware require to compute and give better information for diagnosis of Cancer Treatment using Radiation Therapy. It is important techniques to increase quality of medical image data clinically under pressure to make enriched data and improve accurate treatment and decrease the complications. Computer assisted medical treatment is more impact on now a days to diagnosis the patients in lifesaving . visualization techniques will help the doctors to minimize the overheads and better understanding with accurate manner, most challenging role of a doctor is to perform successfully operations taking decisions, potentially lifesaving with the help of medical imaging. Medical imaging plays a vital role to minimize the overheads of clinicians all over the world. Clinicians are under pressure by evolvement of medical imaging and understanding the problems of patients in an accurate manner. This can be clearly observed in the area of medical imaging computing, the associated diagnosis and medical treatment. The visualization system needs to be clear and gives quality imaging to perform the operations in desired manner. Central Processing Unit (CPU) has serial von Neumann processor ,which is highly optimized to perform series of computations . Replacing today's computers systems are taking a new turn unlike traditional processors with Graphical Processing Unit (GPU) because GPU(2) can handle Massive parallelism to compute high performance accelerator platform for parallel computing ,especially with efficient framework with excellent performance faster and fine for demanding tasks . GPU can increase performance when compared to CPU's which are serving in medical imaging because GPU perform and give quality digital images which help doctors for in treatment. GPU has graphics pipeline to fixed functionality with limited configuration for implement hardware efficiency this restriction helps for the programmers to allow different stages in high level programming languages. This impact to able creates unique