Miracle-dz/UniFAR-FTUs huggingface dataset:
Stem Cell Rev and Rep

Repair of damaged myocardium with pluripotent stem cell derived cardiomyocytes is becoming increasingly more feasible. Developments in stem cell research emphasize the need to address the foreseeable problem of immune rejection following transplantation. Pluripotent stem cell (PSC) derived cardiomyocytes have unique immune characteristics, some of which are not advantageous for transplantation. Here we review the possible mechanisms of PSC-derived cardiomyocytes rejection, summarize the current knowledge pertaining to immunogenicity of such cells and describe the existing controversies. Myocardial graft rejection can be reduced by modifying PSCs prior to their differentiation into cardiomyocytes. Overall, this approach facilitates the development of universal donor stem cells suitable for the regeneration of many different tissue types.
Seeing what we expect to see : attachment style and the perception of facial expressions

iv ACKNOWLEDGEMENTS v INTRODUCTION ~ 1 ~ . REVIEW OF THE RELAVENT LITERA $ METHOD . ~ 21 RESULTS ~ 31 DISCUSSION 41 APPENDIX A. TABLES OF RESULTS ~ 49 APPENDIX B. SPSS PRINTOUTS 52 APPENDIX C. EXPERIENCES IN CLOSE RELATIONSHIPS . IlWENTORY 61 APPENDIX D. APPRAISAL OF EMOTIONS SCALE 63 APPENDIX E. FACIAL EXPRESSION RECOGNITION INSTRUCTIONS 64 ~, _ REFERENCES CITED ~ 65
Using Successive Censuses to Reconstruct the African-American Population, 1930-1990

The Census Bureau's program to estimate the completeness of decennial census counts for age, sex, and race groups relies principally upon what it terms "demographic analysis. " The essence of this approach is to introduce extraneous information on the number of births, deaths, and migrations, derived from noncensus sources, to estimate the true size of each birth cohort at the time of a census (Robinson et al., 1993; Himes and Clogg, 1992). Comparison of this alternative estimate to the census count provides an estimate of the degree of under or over-enumeration in the census, often termed the census undercount. Acceptance of the estimated undercount implies that the census itself is irrelevant to estimating the true size of the population; whatever deficiencies it contained would be accurately and completely revealed by comparison to the estimate based on demographic analysis.
Homology Modelling of Hypoxanthin–Guanine

Hypoxanthin-guanine phosphoribosyltransferase (HPRT) is responsible for catalyzing a reaction which breaks down uric acid in the body. The lack of this enzyme creates a build-up of uric-acid, leading to a neurological problem, joint pain and kidney problem. The condition is called Lesch-Nyhan Syndrome. A comparative modelling of the protein Hypoxanthin-guanine phosphoribosyltransferase is performed using the modeling program modeller9v3.The following structure validation programs PROCHECK, PROSA, VERIFY3D and WHATIF are used. Descret Optimized Protein Energy (DOPE), is a statistical potential used to asses homology model in protein structure prediction. Predicted model can be useful to develop new inhibitor against Lesch-Nyhan Syndrome. CASTp can be used to study surface features and functional regions of proteins. *Corresponding author: Jyotsna choubey, Sub -DIC Bioinformatics center, NIT Raipur (C.G.) 492010, India, Fax: 0771-4062385; Tel:07714062385; E-mail: joys.choubey@gmail.com, ashish.dic@gmail.com Received August 06, 2009; Accepted September 22, 2009; Published September 25, 2009 Citation: Choubey J, Patel A, Khatri S, Dewangan R, Gupta SK, et al. (2009) Homology Modell ing of Hypoxanthin-Guanine hosphoribosyltransferase, Enzyme Involved in Salvage Pathway of Purine Metabolism. J Comput Sci Syst Biol 2: 259-261. doi:10.4172/ jcsb.1000039 Copyright: © 2009 Choubey J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
GEOGRAPHICAL ANALYSIS OF ROAD TRANSPORTATION OF ETHIOPIA MUSHIR ALI AND HAILEMARIAM MEAZA

Roads are considered efficient in transportation system to provide quick, short and medium distance services for the socio-economic development of the country. They are life line for the remote areas where supply and exchange of goods and services are performed by roads. The distribution of roads is not homogenous and orderly fashion to stimulate sectors of economy of developing countries. The present study was conducted in Ethiopia keeping consideration of the objectives to assess growth and distribution of roads by area, population, and to explain causes for regional variations of road development. Secondary data were used for geographical analysis of Ethiopian roads distribution and inter-regional variations between 1992 and 2009. The analysis of the data reflects that growth of constructed roads was 9.86% per year and it was 34.69% during 1993-1994. There was high share of well connected kebeles (73-92%) by community roads in Tigray and Afar regional states. However, availability of roads per 1000 km 2 was higher 96.2 km in Southern Nations Nationalities People Region and Dare Dawa. The length of kebele roads by inhabited area and by high accessibility within 2 km from the roads was in southern and western states.
Segmentation de scènes extérieures à partir d'ensembles d'étiquettes à granularité et sémantique variables

In this work, we present an approach that leverages multiple datasets annotated using different classes (different labelsets) to improve the classification accuracy on each individual dataset. We focus on semantic full scene labeling of outdoor scenes. To achieve our goal, we use the KITTI dataset as it illustrates very well the focus of our paper : it has been sparsely labeled by multiple research groups over the past few years but the semantics and the granularity of the labels differ from one set to another. We propose a method to train deep convolutional networks using multiple datasets with potentially inconsistent labelsets and a selective loss function to train it with all the available labeled data while being reliant to inconsistent labelings. Experiments done on all the KITTI dataset's labeled subsets show that our approach consistently improves the classification accuracy by exploiting the correlations across data-sets both at the feature level and at the label level.
Geochemical Pathways of Fluoride and Boron in the Alluvialaquifer of the Dwarka River Basin, India

Dwarka river basin, situated in the Birbhum district of West Bengal, India is endemic to fluorosis as groundwater contains fluoride as high as 14 mg/L (permissible limit 1.5 mg/L). Co-existence of boron (B) and fluoride (F –1 ) in groundwater, sometimes acts as a tool to predict the source of fluoride. This research was carried out with an objective to identify the geochemical relationship of these two elements and to find out their source(s) in groundwater. pH of groundwater of the study area was mostly neutral to alkaline, F – generally ranged from 0.1 to 10.6 mg/L and boron ranged from 0.01 to 0.5 mg/L. Fluoride and boron showed a strong positive correlation indicating similar source. Fluorapatite observed in sediment samples was considered to be the main source of fluoride. Clay minerals found in the sediment sample were considered to be the most probable source of boron.
Cultural Competency and Child Custody Evaluations: An Initial Step

Cultural diversity and sensitivity are increasingly important factors to consider when choosing who should be appointed to perform a child custody evaluation and how the evaluation should be conducted. This article will discuss factors for attorneys to consider when deciding which evaluator to choose to perform a child custody evaluation and what methods and procedures might be useful for an evaluator to employ when conducting an evaluation of a culturally diversity family unit.
Analysis on Accuracy of Charge-Pumping Measurement with Gate Sawtooth Pulses-Electron Devices, IEEE Transactions on

Charge-pumping (CP) measurement is performed on MOSFET’s with their gates tied to sawtooth pulses. Influence of both rise time (tr) and fall time (tf ) on the CP current of the devices with different channel lengths is investigated at different pulse frequencies. Results show that the dominant mechanism affecting the measurement accuracy is the energy range of interface-trap distribution Dit(E) swept by the gate signal for frequencies below 500 kHz and carrier emission for frequencies above 500 kHz. For frequencies higher than 600 kHz, incomplete recombination could be an additional mechanism when tf is too short. Hence, it is suggested that low frequency is more favorable than high frequency, especially for sawtooth pulses with long tr and short tf , due to little carrier emission and negligible geometric effects even for devices as long as 50 m. However, if high frequency (e.g., 1 MHz) is required to obtain a sufficiently large S/N ratio in the CP current, sawtooth pulses with equaltr and tf should be chosen for the least carrier emission effect and thus more reliable results on interface-state density. Moreover, for both sawtooth and trapezoidal pulses with a typical amplitude of 5 V, a lower limit of 200 ns for tr and tf is necessary to suppress all the undesirable effects in devices shorter than at least 20 m.
Big Five Personality Traits and Disabling Chronic Low Back Pain: Association with Fear-Avoidance, Anxious and Depressive Moods

Purpose Physical dysfunction in chronic low back pain patients is influenced by psychological variables rather than by pain severity. Assessing personality traits may help clinicians address the complexity of patients’ experiences and design treatments that target these vulnerabilities. This study aimed to identify the distinguishing personality traits of a cohort of patients with disabling chronic low back pain and to determine associations between those traits and fear-avoidance beliefs, depressive, and anxious moods. Patients and Methods This cross-sectional study included 102 chronic low back pain patients (57% male), who failed standard management and were referred to a multidisciplinary rehabilitation program. All patients completed the five domains of the NEO Personality Inventory (NEO PI)–Revised (Neuroticism, Extraversion, Openness to experience, Agreeableness and Conscientiousness), the Tampa Scale for Kinesiophobia (TSK), and the Hospital Anxiety and Depression Scale (HADS). One-sample t-test was used to compare sample personality means with average population norms. Association between the five personality domains with TSK and HADS was assessed using Pearson’s correlation, adjusted for patient demographics and pain-related variables. Linear regression was used to estimate associations adjusted for covariates. Results Both men and women had significantly lower scores in the Openness to experience domain and significantly higher scores in the Conscientiousness domain than the general population norms. After adjusting for covariates, Neuroticism was associated with higher fear-avoidance, depression and anxiety scores. Conversely, Extraversion and Openness to experience negatively correlated with depression scores. Extraversion also inversely correlated with fear-avoidance. Conscientiousness negatively correlated with depression and anxiety after adjustment. Conclusion Patients with disabling chronic low back pain show personality characteristics that deviate significantly from the normal population norms but do not reach maladaptive forms of personality disorders. Clinicians would benefit from assessing patients’ personality traits to address protective and risk factors for psychological distress, particularly in difficult-to-treat, highly disabled low back pain patients.
Nivicolous myxomycetes in agar culture: some results and open problems

A method to cultivate nivicolous species of myxomycetes in agar is proposed. Sixty three specimens of nivicolous myxomycetes representing 10 taxa (9 species and 1 variety) from 5 genera and 3 families were tested for ability to germinate in agar plates at room temperature. Germination occurred in 28 specimens of 6 species. In some samples microplasmodia started to appear at the same conditions, but in most samples further developmental stages were observed only when cultures were kept at +2°C. Two species (Lepidoderma chailletii and Physarum nivale) showed plasmodia formation, but we did not manage to cause sporulation. Partial sequences of the SSU gene obtained from cultured amoebae of two L. chailletii and one P. nivale specimens were identical to those obtained from their spores and comparison with GenBank sequences proved species identity. Some data about tolerance of L. chailletii amoebae to low temperatures were obtained that could be helpful in understanding the ecology of nivicolous myxomycetes.
Methylenetetrahydrofolate reductase polymorphism and capecitabine-induced toxicity in patients with gastric cancer

Purpose: To evaluate the effect of methylenetetrahydrofolate reductase (MTHFR) polymorphism on toxicity in gastric cancer (GC) patients treated with capecitabine. Methods: One hundred and twenty-six GC patients were treated with capecitabine in the study. DNA from GC patients was genotyped for MTHFR A1298C using direct sequencing. Toxicity evaluations were graded. Clinical response was assessed. Results: In 87.3 % of the patients, capecitabine toxicity was observed. As for MTHFR A1298C polymorphism, 55.6 % patients who exhibited it were associated with reduced MTHFR activity. MTHFR A1298C was associated with capecitabine-related toxicity (p = 0.008); in addition, MTHFR A1298C was significantly associated with gastrointestinal toxicity (p = 0.026), but not with other types of toxicity. Conclusion: The findings suggest that MTHFR A1298C may be useful for predicting toxicity in GC patients receiving capecitabine treatment, especially gastrointestinal toxicity. Keywords: MTHFR, Polymorphism, Gastric cancer, Toxicity
Commentary: Authenticating Social Media Evidence in California, the Social Media Capital of the World

Hollywood, California, is known as the movie capital of the world. But Silicon Valley, California, has become the social media capital of the world. Social media companies such as Facebook, YouTube, and Twitter now reach more than two billion people around the world every day.1 Americans alone spend approximately 61/2 hours per week on social media, which equates to checking their social media almost 17 times per day and at least once every waking hour.2 The dramatic increase in social media activity has created a treasure trove of evidence for both criminal and civil attorneys. This article will highlight three California cases that provide guidance on how to authenticate and lay the proper foundation for social media evidence.
EQUAL OPPORTUNITIES AND THE RECONCILIATION OF WORK AND FAMILY WITHIN THE CONSTRUCTION PROCESS

In 1996 the Latham Working Group Eight (WG8) report criticized the construction industry for its poor equal opportunities record. Since the publication of the report, a significant amount of research has been conducted within the industry on equal opportunities. Most of this work has concentrated on women, and little attention has been paid to the circumstances of other under-represented groups such as ethnic minorities, or the issues affecting disabled workers, both employed and seeking work within the industry. Furthermore, the issue of creating balance and harmony between employees’ work and home life (reconciliation of work and family) has also been relatively ignored. This paper discusses the meaning of the terms “equal opportunities” and “reconciliation of work and family” and the ways in which the industry could benefit from improvements in their implementation. The paper also discusses the findings of preliminary research by the authors, which was undertaken to establish the awareness and knowledge of, the legislation and directives which promote equality of opportunity and the reconciliation of work and family; and the attitudes towards their implementation amongst a sample of construction organizations. The preliminary study has found that, although most of those sampled were aware of both the legislation concerned with and the concepts of equal opportunities and family-friendliness, few of the organizations indicated that they implemented polices which would actively promote either issue. Many respondents also indicated that the nature and culture of the industry prevented it from becoming more equal and family friendly. The paper concludes by setting out an agenda for further research in this field.
Foreign direct investment, institutions and economic growth: threshold effect

This paper examines whether the effect of foreign direct investment on economic growth is dependent upon the institutional level for the MENA region divided into middle (oil importer) and high-income countries (oil exporter). Using GMM system, our results show that FDI alone plays an ambiguous role in contributing to economic growth covering the period from 1980-2013. Under the threshold regression, technique developed by Caner and Hansen (2004) we find that institutions are important factors in explaining FDI. It is found that FDI enhances growth through government stability and corruption in the MENA region. Results highlight that even if countries are above the institutionnal threshold, the effect of FDI on growth are higher in the middle income countries than in the high income countries.
Implementation of the Educational Program Among the Patients Treated Surgically Due to the Damage of the Part of the Centural Spine

Introduction . Treatment of patients with spine disorders is a subject of interest to many medical disciplines. Most patients complaining of back pain are successfully cured with conservative methods, some require surgical procedures. In the entire therapy process, regardless of the method of treatment, patient education cannot be ignored. Aim . Evaluation of the implementation of the educational program conducted among patients treated surgically for diseases of the cervical spine. Material and Methods . The research was conducted among 156 patients on the Neurosurgery and Neurotraumatology Ward of The University Hospital No. 2 in Bydgoszcz, treated surgically for diseases of the cervical spine. The original educational program was carried out during the hospitalization of the patient in the ward. The program evaluations were planned through a preliminary and final verifying survey for each participant of the program. The collected material was subject to statistical analysis. Results . Women constituted a larger group — 102 respondents (64.6%). The average age of the respondents was — 54.2 years. Before the implementation of the program, 92 people (58.2%) said they had partial knowledge of cervical spine diseases, but 48 respondents (30.4%) said they knew very little and only 6 patients (3.8%) indicated that they knew a lot. After the education, the vast majority of respondents claimed that their knowledge about life with cervical spondylosis disorders had improved significantly — 149 people (94.3%). Conclusions . The respondents evaluated the program very well; almost all of them acknowledged that their state of knowledge about the life and prevention of spine diseases had definitely improved. There was a significant improvement of the respondents’ knowledge on the causes of back pain, mainly in people with primary education. (JNNN 2018;7(3):96–103)
The Comparison of the Efficacy and Safety of Intralesional Triamcinolone Acetonide and Methotrexate Injections for the Treatment of Fingernail Psoriasis

Received/Geliş Tarihi: 04.01. 2018 Accepted/Kabul Tarihi: 27.04. 2018 Objectives: Studies have demonstrated that the clinical efficacy and remission duration of intralesional corticosteroids in nail psoriasis are highly variable. Moreover, good clinical results have been reported after methotrexate injection in a case study with nail psoriasis. This study aimed to investigate the efficacy and safety of intralesional injection of triamcinolone acetonide and methotrexate in patients with fingernail psoriasis. Materials and Methods: Thirty-two patients diagnosed with fingernail psoriasis with at least three affected nails were included. Diluted triamcinolone acetonide, methotrexate and serum physiologic solution were randomly injected into three different fingernails having similar nail area psoriasis severity index (NAPSI) scores for four sessions. We compared the signs of nail matrix and nail bed involvement. The severity of fingernail psoriasis was investigated using NAPSI and modified NAPSI. Results: The responses evaluated by the NAPSI scores were similar in nails treated with methotrexate and triamcinolone acetonide. The improvement of the signs of nail matrix involvement was significantly higher in nails treated with methotrexate, but the improvement of the signs of nail bed involvement was similar in all groups. The improvement of onycholysis was significant only in nails treated with triamcinolone. On the other hand, the improvement of pitting and leukonychia were significant only in nails treated with methotrexate. Conclusion: Methotrexate injection might be a better treatment choice for fingernail psoriasis with the signs of nail matrix involvement and triamcinolone acetonide injection for the fingernail psoriasis with the signs of nail bed involvement.
The intracellular pathogen Chlamydia trachomatis targets proteins of the ESCRT machinery

Chlamydia trachomatis is an obligate intracellular human pathogen. It is the first infectious cause of blindness and the most common cause of sexually transmitted diseases of bacterial origin. Using a strain of C. trachomatis serovar L2 expressing a fluorescent protein we developed microscopy and flow cytometry based methods to quantify several steps of its developmental cycle. These methods will facilitate future studies aimed at testing anti-bacterial compounds or various culture conditions. Chlamydiae interfere with many cellular processes, in particular via the secretion of bacterial proteins through a type 3 secretion (T3S) system. We identified a family of proteins that possess T3S signals. They share a domain designated as DUF582, which is only found in pathogenic chlamydiae. We showed that the five DUF582 proteins of C. trachomatis are expressed from the mid phase of infection. We demonstrated that the protein Hrs is a common interactor for the DUF582. In addition the N-terminal part of the DUF582 protein CT619 interacts with Tsg101. Hrs and Tsg101 are both important components of the ESCRT machinery, which is an ancient machinery required for several processes involving membrane fission.Using RNA interference we showed that Hrs and Tsg101 are dispensable for bacterial entry and growth. This last result suggest that DUF582 proteins actually prevent Hrs and/or Tsg101 driven processes. Alternatively, the bacteria might highjack the ESCRT machinery but redundant mechanisms would explain the absence of phenotype on bacterial development observed in the silencing experiments. We discuss three hypotheses as to the possible role of the DUF582 proteins in infection.