Miracle-dz/UniFAR-FTUs huggingface dataset:
Sustenance and sustainability: maximizing the impact of school gardens on health outcomes

Abstract Objective School garden programmes have become popular action-oriented learning environments in many countries, often driven by converging priorities of environmental sustainability and healthful diets. Many of these programmes have assessed the impact on dietary intake, specifically fruit and vegetable intake, and related dietary behaviours, such as knowledge, preference, motivation, intention and self-efficacy to eat and prepare fruit and vegetables. The objective of the present study was twofold: (i) to review published garden-based programmes conducted in schools targeting dietary intake and/or determinants of dietary behaviour in children; and (ii) to identify similar strategies and components employed by these garden-based programmes. Design The review included thirteen studies that have examined the impact of garden-based programmes conducted in school, either during school hours or in after-school settings, on dietary behaviours in children (kindergarten through 8th grade students). Results Three of the reviewed studies did not have a comparison or control group and simply evaluated within-group changes after a garden intervention. None of the reviewed studies were randomized, but were assigned based on school’s interest and timing of new school gardens being built. Out of the eleven programmes that examined dietary intake, six found that the programme resulted in increased vegetable intake, whereas four showed no effect. Seven of the eight studies that measured preference found that the programmes resulted in increased preference for vegetables. Gardening programmes also resulted in improved attitudes towards, willingness to taste, identification of and self-efficacy to prepare/cook fruit and vegetables. Similar strategies/components employed by the majority of the programmes included: ‘hands on’ curriculum, incorporation of a cooking component, providing the instructors, parental and stakeholder support, food provision and using the garden as the focal point for media promotion. Conclusions Some of the garden programmes resulted in increased vegetable intake, which has positive implications for both environment sustainability and health-related outcomes. Further, the majority resulted in some improvement in behaviour determinants more generally. However, more research is warranted to understand how to achieve long-term improvements in dietary behaviours and how to sustain the garden-based programmes in schools.
Image segmentation based on Fuzzy hypergraph Model

This paper proposes a fuzzy hypergraph model (FHM) for image representation. This model uses both local and globe information of images rely on location space and color space respectively. And by using hypergraph, this model could represent the complex relationships between more than two pixels instead of simple graph which only represent pairwise relationships. This paper uses a semi-supervised learning method which aims to FHM to segment image. Experimental results on various images show that the proposed method is good at classifying the unlabeled pixels.
g-linolenic acid therapy of human glioma-a review of in vitro , in vivo , and clinical studies

g-linolenic acid (GLA) induced apoptosis of tumor cells without harming normal cells. Both cyclo-oxygenase (COX) and lipoxygenase (LO) inhibitors did not inhibit the selective tumoricidal action of GLA in some, but not all, tumor cells suggesting that GLA by itself is active. In contrast, anti-oxidants such as vitamin E blocked the tumoricidal action of GLA. GLA-treated tumor but not normal cells produced a 2–3-fold increase in free radicals and lipid peroxides. GLA decreased the anti-oxidant content of tumor cells, expression of oncogenes ras, and Bcl-2, enhanced the activity of p53, protected normal cells and tissues from the toxic actions of radiation and anti-cancer drugs, enhanced the cytotoxic action of anti-cancer drugs and reversed tumor cell drug resistance. In the animal glioma model, GLA induced tumor regression and preserved the surrounding normal brain tissue. In three open-label clinical studies, intra-tumoral injection of GLA induced signifi cant reduction of glioma without any signifi cant side effects. The low neurotoxicity of GLA to normal brain neurons and selective activity against tumor cells suggests that it could be an effective anti-glioma molecule.
SIGNIFICANT Laparoscopic better than open in all three parameters Contralateral Occult Hernia Detection And Less Tissue Handling Made Lpec Superior Contralateral Occult Hernia Detection And Less Tissue Handling Made Lpec Superior

Introduction: Herniotomy /open surgery has been the time honored treatment for congenital inguinal hernia. Laparoscopic surgery has recently emerged as an alternative but wider adoption of laparoscopic surgery remains controversial.Therefore the need for comparison of the two techniques for addressing congenital inguinal hernia propelled us to prospectively evaluate the differences and outcomes. Methods: This prospective study was conducted in our hospital from July 2015 to July 2016 with the approval of the hospital ethical committee.60 children underwent either Laparoscopic Surgery(38) OR Open Surgery(22) for congenital inguinal hernia. Operative time, intra and postoperative complications, postoperative pain, hospital stay and cosmetics aspects were recorded and compared for difference in outcome. Patients were followed for an average of 4months to evaluate the outcomes. Results: In open surgery unilateral herniotomy was done. In laparoscopic surgery, contralateral patency of processusvaginalis was detected intraoperative and repaired simultaneously. Laparoscopic surgeries were quicker to perform than open surgeries. Cosmesis, complications, postop pain were less in laparoscopic Surgery than Open Surgery. Conclusion: We conclude that LPECmethod is a safe and efficacious procedure with its own advantages that should be viewed as an acceptable alternative to the traditional open approach.
The Database Normalization Theory and the Theory of Normalized Systems: Finding a Common Ground

Database normalization theory offers formalized guidelines how to reduce data redundancy and thus problems that it causes in databases. More lately, researchers have started to formalize ideas that the problems caused by unwanted dependencies and redundancy can be observed in case of any modular system like software, hardware, or organization. To tackle these problems, they have proposed the theory of normalized systems that complete application frees systems of combinatorial effects and thus the impact of a change in a system does not depend on the system size. At the time of writing this paper, the explanations of the theory of normalized systems do not say much about database normalization. We think that the theories are deeply related. In this paper, we search a common ground of the database normalization theory and the theory of normalized systems.
Classification of digital signals in cognitive radio based on second-order statistical approach

An approach for multiclass digital signal classification based on second-order statistical features and multiclass Support Vector Machine (SVM) classifier is proposed. The proposed system is designed to recognize three different modulation schemes such as DPSK, PSK and MSK. The 2nd order cumulants of the real and imaginary parts of the complex envelope are extracted and these statistical features are given to multiclass SVM classifier for classification. The modulated signals are passed through the Rayleigh channel and Additive White Gaussian Noise (AWGN) channel before feature extraction. The evaluation of the system is carried on using 400 generated signals. The overall classification rate of the proposed system for various SNR levels is over 83%.
HuM291, a humanized anti-CD3 antibody, is immunosuppressive to T cells while exhibiting reduced mitogenicity in vitro.

BACKGROUND OKT3, a mouse monoclonal antibody (Ab) specific for the human CD3 complex on T cells, is a potent immunosuppressive agent used for the treatment of acute allograft rejection. The utility of the drug has been limited by a neutralizing anti-mouse Ab response and adverse side effects resulting from T cell activation and systemic cytokine release. T cell activation is caused by OKT3-mediated cross-linking of T cells and Fc receptor-bearing cells. Studies in the mouse model have shown that global T cell activation is not necessary for immunosuppression, as Fc receptor-nonbinding anti-CD3 Abs can suppress graft rejection in the absence of the activation effects seen with Fc receptor-binding Abs. Thus, a humanized anti-CD3 antibody with a low affinity for Fc receptors might improve immunosuppressive therapy by reducing the side effects associated with OKT3. METHODS We developed a mouse monoclonal Ab, M291, which competes with OKT3 for binding to T cells. Humanized, complementary-determining region-grafted versions of M291 featuring various Fc were engineered, including a previously described IgG2 mutant deficient in Fc receptor binding (HuM291). RESULTS Compared with OKT3 and HuM291-IgG1, HuM291 was significantly less mitogenic to T cells in vitro and induced the release of much lower levels of the cytokines tumor necrosis factor-alpha, interferon-gamma, and interleukin-10. Despite this reduction in T cell activation, HuM291 retained the ability to modulate the CD3 complex and inhibit the mixed lymphocyte reaction. CONCLUSIONS When evaluated in vivo, HuM291 may be an immunosuppressive agent associated with less of the acute toxicity and immunogenicity seen with OKT3 therapy.
DESIGN AND SIMULATION OF A FLOATING BRIDGE FOR OPEN-ENDED WINDING MOTOR DRIVE APPLICATIONS

In this paper a dual two-level inverter is presented which reduces the size and weight of the system for an open end winding induction motor drive application. This paper presents a dual three phase open end winding induction motor drive. The drive consists of a three phase induction machine with open stator phase windings and dual bridge inverter supplied from a single DC voltage source. The aim of this topology is to eliminate the requirement for a bulky isolation transformer whilst achieving multi-level output voltage waveforms. To achieve multi-level output voltage waveforms a floating capacitor bank is used for the second of the dual bridges. The capacitor voltage is regulated using redundant switching states at half of the main dc link voltage. This particular voltage ratio (2:1) is used to create a multi-level output voltage waveform with three levels. The fuzzy controller is the most suitable for the human decision-making mechanism, providing the operation of an electronic system with decisions of experts. A modified modulation scheme is used to improve the waveform quality of this dual inverter. This paper also compares the losses in dual inverter system in contrast with single sided threelevel NPC converter. By using the fuzzy controller for a nonlinear system allows for a reduction of uncertain effects in the system control and improve the efficiency. By using the simulation results we can analyze the proposed method.
Progress in the development of thermocouple calibration at Rh-C eutectic point

The rhodium-carbon (Rh-C) eutectic-point (1657 °C) cell having an outer diameter of 44 mm and a height of 297 mm was constructed for thermocouple calibration. The melting and freezing curves at the Rh-C eutectic point were evaluated using type R thermocouples. The repeatability of the melting and freezing curves, the effect of the surrounding temperature, and the heat flux effect in the cell were evaluated.
Neutrophils, Not Monocyte/Macrophages, are the Major Splenic Source of Postburn IL-10

Burn induces myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature polymorphonuclear neutrophils (PMNs) and monocytes, which protect against infection. Previous work from our laboratory demonstrated that inflammatory monocytes (iMos) were the major MDSC source of TNF-&agr; in the postburn spleen, and we hypothesized that they were also the major source of postburn IL-10. To test this hypothesis, we examined cytokine production by postburn CCR2 knockout (KO) mice, which have fewer iMos than burn wild-type (WT) splenocytes, but equal numbers of PMNs and F4/80 macrophages. Using cell sorting and/or intracellular cytokine techniques, we examined IL-10 production by postburn PMNs and iMos. Finally, we compared IL-10 production by postburn PMNs and iMos with culture-derived MDSCs. Splenocytes from postburn CCR2 KO mice produced less IL-6 and TNF-&agr; than WT burn splenocytes in response to LPS, but KO and WT burn splenocytes produced equal amounts of IL-10 in response to peptidoglycan. Depletion of PMNs from postburn splenocytes led to reductions in IL-10 and increases in IL-6 and TNF-&agr; in response to peptidoglycan, but not in response to LPS. Sorting or intracellular cytokine techniques gave consistent results: Burn PMNs made more IL-10 than sham PMNs and also more IL-10 than burn or sham iMos. Polymorphonuclear neutrophil and iMos subpopulations from culture-derived MDSCs produced the same cytokine profiles in response to LPS and peptidoglycan as did the PMNs and iMos from postburn spleens: PMNs made IL-10, whereas iMos made IL-6. Finally, LPS-induced mortality of burn mice was made worse by anti-Gr-1 depletion of all PMNs and 66% of iMos from burn mice. This suggests that PMNs play a primarily anti-inflammatory role in vitro and in vivo.
Evidence-based medicine in day surgery

Purpose of review To present the evidence available for the management of pain, for the prevention of nausea and vomiting, and for the best anaesthetic technique during ambulatory surgery. Recent findings Paracetamol and nonsteroidal anti-inflammatory drugs are effective analgesics with a low number needed to treat, and are recommended when not contraindicated. Droperidol, dexamethasone and ondansetron are equally effective in the prevention of postoperative nausea and vomiting during ambulatory surgery. The choice of the anaesthetic technique appears to play a minor role in recovery from anaesthesia or in the occurrence of minor postoperative complications or home discharge, except for the use of total intravenous anaesthesia for the prevention of postoperative nausea and vomiting. Summary Pain should be prevented adequately and treated vigorously. Postoperative nausea and vomiting is common and should be prevented in the at-risk patient. The choice of inhalation agents during ambulatory surgery is of minor importance in recovery from anaesthesia.
A zero suppressed binary decision diagram-based test set relaxation for single and multiple stuck-at faults

This paper presents a new zero suppressed binary decision diagram (ZBDD)-based approach for obtaining larger number of relaxed bits. These test sets find major application in reducing the power consumed during testing. Experiments performed on single and multiple stuck-at faults using ZBDDs show better results in terms of percentage of relaxation over the existing comparable BDD-based approaches. Moreover using these relaxed test vectors and by suitable X-filling methods average switching activity (ASA) of the circuit can be reduced, which will reduce the power dissipation during testing.
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits

Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gα subunits and thus facilitate termination of signaling initiated by G protein-coupled receptors (GPCRs). RGS proteins hold great promise as disease intervention points, given their signature role as negative regulators of GPCRs—receptors to which the largest fraction of approved medications are currently directed. RGS proteins share a hallmark RGS domain that interacts most avidly with Gα when in its transition state for GTP hydrolysis; by binding and stabilizing switch regions I and II of Gα, RGS domain binding consequently accelerates Gα-mediated GTP hydrolysis. The human genome encodes more than three dozen RGS domain-containing proteins with varied Gα substrate specificities. To facilitate their exploitation as drug-discovery targets, we have taken a systematic structural biology approach toward cataloging the structural diversity present among RGS domains and identifying molecular determinants of their differential Gα selectivities. Here, we determined 14 structures derived from NMR and x-ray crystallography of members of the R4, R7, R12, and RZ subfamilies of RGS proteins, including 10 uncomplexed RGS domains and 4 RGS domain/Gα complexes. Heterogeneity observed in the structural architecture of the RGS domain, as well as in engagement of switch III and the all-helical domain of the Gα substrate, suggests that unique structural determinants specific to particular RGS protein/Gα pairings exist and could be used to achieve selective inhibition by small molecules.
A Comparison of the Efficacy and Safety of Irbesartan/Hydrochlorothiazide Combination Therapy with Irbesartan Monotherapy in the Treatment of Moderate or Severe Hypertension in Diabetic and Obese Hypertensive Patients: A Post-Hoc Analysis Review

Abstract Hypertension is difficult to treat in patients with type 2 diabetes mellitus (T2DM) or obesity. Combination therapies are often required to effectively lower blood pressure (BP) and attain BP goals. In this post-hoc analysis of 2 prospective, randomized, controlled studies in patients with uncontrolled or untreated moderate or severe hypertension, the efficacy and safety of treatment with irbesartan/hydrochlorothiazide (HCTZ) and irbesartan was assessed in 2 separate analyses: patients with diabetes (n = 143) and by obesity status (n = 1125). Patients received irbesartan/HCTZ (150 mg/12.5 mg titrated to 300 mg/25 mg) or irbesartan (150 mg titrated to 300 mg) for 7 (severe hypertension study) or 12 (moderate hypertension study) weeks. Efficacy comparisons between treatment groups were performed using Fisher's exact tests. After 7 to 8 weeks of treatment, systolic BP (SBP)/diastolic BP (DBP) decreased in patients with diabetes by 26.9/17.8 mm Hg and 21.8/15.8 mm Hg after irbesartan/HCTZ and irbesartan treatment, respectively (P [SBP] = 0.09, P [DBP] = 0.27). In obese patients (n = 544), SBP/DBP decreased by 29.4/20.2 mm Hg and 20.1/15.9 mm Hg after irbesartan/HCTZ and irbesartan treatment, respectively (P < 0.0001). More patients with T2DM reached the BP goal of < 130/80 mm Hg at week 7 to 8 in the irbesartan/HCTZ group than in the irbesartan group (12% vs 5%), although not statistically significant (P = 0.22). Significantly more obese patients reached their respective BP goals in the irbesartan/HCTZ group than in the irbesartan group (48% vs 23%; P < 0.0001). Treatment-emergent adverse event rates were similar between treatment groups regardless of the presence of diabetes or body mass index (BMI) status. In patients with moderate or severe hypertension and with a BMI ≥ 30 kg/m2, initial treatment with irbesartan/HCTZ combination therapy was more effective than irbesartan monotherapy.
Analysis of features of selected models for simulation of lightning threat

A comparison of currents and fields calculated for two models of a lightning strike to a lightning protection system is presented. One model is a simulation of a real lightning strike, taking into account the length of the lightning channel. The second one simulates the experimental setup with a lumped generator of surge currents. Differences resulting from disregarding of the lightning channel length are discussed.
Response to pegylated interferon plus ribavirin in HIV‐infected patients with chronic hepatitis C due to genotype 4

Summary. Hepatitis C virus (HCV) genotypes 1 and 4 respond less well to pegylated interferon (pegIFN) plus ribavirin (RBV) therapy. For this reason most studies merge these two genotypes when assessing virological response. However, in most trials the HCV genotype 4 population is rather small, and conclusions are mainly derived from what occurs in HCV‐1 patients. All HCV‐4 patients coinfected with HIV who received pegIFN plus RBV in two different multicentre studies, PRESCO and ROMANCE, conducted respectively in Spain and Italy, were retrospectively analyzed. Baseline plasma HCV‐RNA, proportion of patients with HCV‐RNA <10 IU / mL at week 4 (rapid virological response), and HCV‐RNA declines >2 logs at week 12 (early virological response, EVR) were all assessed as predictors of sustained virological response (SVR). Overall, 75 patients (60 men) were evaluated. Median age was 40 years and median CD4 count 598 cells / mm3; 49% had plasma HIV‐RNA <50 copies / mL; 71% had elevated liver enzymes and 31% had advanced liver fibrosis (Metavir F3–F4). Median serum HCV‐RNA was 5.7 log IU / mL. Rapid virological response was attained by 10 (20%) patients and EVR by 26 (42%). Using intention‐to‐treat and on‐treatment (OT) analyses, SVR was achieved by 21 / 75 (28%) and 21 / 62 (34%) of HCV‐4 patients, respectively. In the multivariate analysis (OT), baseline HCV‐RNA (OR 0.09 for every log increment; 95% CI: 0.01–0.7) and EVR (OR: 7.08; 95% CI: 1.8–27.2) were significantly and independently associated with SVR. This is the largest series of HIV‐infected patients with chronic hepatitis C due to HCV‐4 treated with pegIFN plus RBV examined so far and the results show that HCV‐4 behaves similarly to HCV‐1. Therefore, these patients should be considered as difficult to treat population. Baseline serum HCV‐RNA and EVR are the best predictors of SVR in HCV‐4 / HIV‐coinfected patients.
Un análisis comparativo de los programas de fomento de empleo autónomo en España

En este articulo se lleva a cabo un analisis de los programas de fomento del empleo autonomo en Espana, tanto a nivel nacional como autonomico. Las principales politicas nacionales son el programa de capitalizacion de las prestaciones por desempleo, los microcreditos del ICO, el programa "Emprender en femenino" y los desarrollados bajo la OM 21/02/86. En el ambito autonomico, dada la variedad de medidas, se realiza un analisis comparativo en terminos de requisitos de los solicitantes, exclusiones, obligaciones de los beneficiarios y cuantia de la subvencion.