Miracle-dz/UniFAR-FTUs huggingface dataset:
Entwicklung ganzheitlicher logistischer Auditverfahren

KURZFASSUNG: Die Bedeutung der Logistik als integrale Unternehmensfunktion nimmt kontinuierlich zu und viele Unternehmen betrachten ihre Logistik bereits als entscheidenden Wettbewerbsvorteil. Um die Fahigkeit der eigenen Logistik richtig bewerten zu konnen und darauf folgend Verbesserungspotentiale bestmoglich einschatzbar zu machen, braucht es geeignete Verfahren. Diese Veroffentlichung stellt drei bereits bestehende bzw. gerade in Entwicklung befindliche Auditverfahren zur Bewertung der logistischen Strome dar, zeigt wie diese untereinander interagieren konnen um solidere Ergebnisse zu erbringen als es bei einer Einzelanwendung der Fall ware und in welchen Situationen sie adaptiv am sinnvollsten eingesetzt werden sollten. 1 EINLEITUNG Eine Erhebung der logistischen Leistungsfahigkeit erfordert die parallele Betrachtung der drei logistischen Strome (Materialfluss, Informationsfluss und Wertefluss), was aber mit einer erheblichen Komplexitat einhergeht [1]. Das stellt fur viele Unternehmen ein intern nicht mehr bewaltigbares Vorhaben dar. Die zentrale Fragestellung lautet hiermit: Wie kann die gesamtheitliche logistische Struktur eines Unternehmens so erfasst, abgebildet und gemessen werden, dass diesem Unternehmen mit moglichst geringem Aufwand konkrete logistische Verbesserungspotentiale aufgezeigt werden konnen? Zur Beantwortung dieser Fragen, wurden die nachfolgend vorgestellten Auditverfahren entwickelt sowie existierende Verfahren angepasst.
Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry of Dextran and Dextrin Derivatives

Application of matrix-assisted laser desorption/ionization (MALDI) to the analysis of dextran and dextrin derivatives, specifically glucose saccharides, by time-of-flight (TOF) mass spectrometry is reported. MALDI-TOF analysis was carried out on alpha-, beta-and gamma-cyclodextrin, two O-methylated beta-cyclodextrins of differing degrees of substitution (DS) and dextrans (a linear glucose saccharide), as pure and doped solutions and as mixtures of two or more of these analytes. Doping was carried out with trace amounts of inorganic salts. The purpose of the analysis of the cyclodextrins was to determine whether they would form inclusion complexes with the various added cations, or whether less specific cation addition/exchange was occurring either prior to desorption or in the gas phase.
Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins

Camptothecins (CPT) activate S or G2-M arrest and the homologous recombination (HR) repair pathway in tumor cells. In this process, both checkpoint kinases 1 and 2 (Chk1 and Chk2, respectively) are activated, but their differential roles, especially in the coordination of checkpoint and repair control, and potential clinic relevance remain to be fully elucidated. In this study, the repairable double-strand breaks were induced in human colon cancer HCT116 cells by 1-h exposure to 25 or 100 nmol/L CPT and its novel derivative chimmitecan. The cellular disposal of double-strand breaks was reflected as the progressive dispersal of γ-H2AX foci, reduction of “comet” tails, dynamic activation of RAD51-mediated HR repair, and reversible G2-M arrest. In this model, the differential kinetics of Chk1 and Chk2 activation was characterized by the progressively increased phosphorylation of Chk2 until 72 h, the degradation of Chk1, and the disappearance of phosphorylated Chk1 48 h after drug removal. Using RNA interference, we further showed that Chk2 was essential to G2-M arrest, whereas Chk1 was mainly required for HR repair in CPT-treated HCT116 cells. Moreover, Chk2, rather than Chk1, predominated over the control of cell survival in this model. The differential roles of Chk1 and Chk2 in regulating HR repair and G2-M phase arrest were also confirmed in HT-29 colon cancer cells. Together, these findings systematically dissect the differential roles of Chk1 and Chk2 in a favorable model pursuing CPT-driven DNA damage responses, providing critical evidence to further explore checkpoint modulation, especially Chk2 inhibition as a therapeutic strategy in combination with CPT. [Mol Cancer Ther 2008;7(6):1440–9]
Feasibility and Profitability of Optimization by Data-Type Specification in Ruby

The paper aims at proposing methods to achieve performance optimization using data-type specification in an object-oriented programming language, Ruby. In particular, the addition operator has been considered in detail in the paper to prove the advantages of the proposed approach. To support the idea, experiments were conducted to establish the feasibility and profitability of the optimization in Ruby using data-type specification and finally it is shown that the proposed methodology results in significant speedups in dynamically typed languages, like Ruby.
Inhibition of amino acid transport into lymphoid cells by the glutamine analog L-2-amino-4-oxo-5-chloropentanoate.

Transport of L-glutamine and of the chloroketone glutamine analog L-2-amino-4-oxo-5-chloropentanoate into lymphoid cells is mediated by the same system. Arginine and a number of other amino acids (e.g., glutamate, aspartate, and lysine) are transported to a much lesser extent by this system. However, after uptake of the chloroketone into the cells, the transport of glutamine, arginine, and other amino acids is markedly inhibited, due evidently to reaction of the chloroketone with intracellular components that are involved in amino acid transport. The chloroketone acts more effectively on growing than on resting cells. Treatment of lymphoid cells with the chloroketone or with L-chloro-2,4-dinitrobenzene leads to rapid and complete depletion of intracellular glutathione without affecting cell viability. These reagents appear to be useful experimental tools for studies of glutathione function and metabolism.
Going Beyond the Classic News Narrative Convention: The Background to and Challenges of Immersion in Journalism

The disappearance of the screen’s physical barrier, the fourth wall, challenges many of the narrative conventions traditionally used in the traditional journalistic account. This is an area in which we are still taking the first steps, but these moves have already raised interesting narratological challenges. Technological development allows us not only to have the sensation of being elsewhere, but also of interacting with the storytelling elements. In this article, the author reviews the steps that have been taken up to the present time in the use of these platforms for news and shows the reflections carried out by disciplines connected with narrative construction on the challenges of this new way to tell the story of what is happening in the world. The implications of being inside the scene of the action and being able to interact with it means rethinking the conventions of audiovisual editing and the visual perspective of the audience, as well as the relevance of the three-dimensional nature of real sound and the freedom to act inside the story without modifying the real course of the events.
New beamforming method based on radial- basis function neural network processing in SαSG distribution noise environments

The under-determined problem of the blind source separation (BSS) for chaotic signals is intractable. A BSS algorithm is proposed and realized in this paper, which is also applied into a secret communication scheme. Both theoretical analysis and numerical simulations demonstrate that the proposed method is of higher security and precision for recovered source signals even when channel noise is very high.
Normas de completamento de radicais de palavras portuguesas

O uso da memoria implicita revela-se quando o desempenho numa tarefa e facilitado mesmo na ausencia de recordacao consciente da experiencia previa (Graf & Schacter, 1985). Grande parte da investigacao sobre a recuperacao nao consciente baseou-se na utilizacao de tarefas de memoria implicita que tem vindo igualmente a ser utilizadas no estudo da producao nao consciente de memorias falsas no paradigma DRM (Deese, 1959; Roediger & McDermott, 1995). Este procedimento experimental consiste na apresentacao de listas de palavras associadas a uma palavra-chave nao apresentada, designada de item critico, seguida de tarefas de evocacao e/ou reconhecimento. O presente estudo debruca-se sobre a construcao de normas de completamento de 223 radicais de palavras portuguesas, elaboradas a partir de listas de associados criadas de raiz para o contexto portugues (Albuquerque, 2005). O material aqui apresentado podera ser usado em varios estudos, nomeadamente os que envolvam tarefas de memoria implicita de completamento de palavras.
ISOLATION OF ESCHERICHIA COLI FROM YOUNG LIONS, DOGS AND SHEEP WITHDETERMINATION OF ANTIBIOTIC RESISTANCE

E. coli were isolated from fecal samples and the antibiotic resistance pattern of E. coli was determined by means of disc diffusion assay. The resistance pattern determined streptomycin, amoxicillin, ciprofloxacin, ceftriaxone amoxicillin/clavulanic acid, cefepimeandazteronam. E. coli were isolates reported as resistant to more than five antibiotics (multidrug-resistant). This might result from expansion of the antibiotic resistance image among animals and from the animals to human living in close contact with them. The present study designed to isolate Escherichia coli and estimate its antibiotic resistance that isolated from young lions, dogs and sheep to establish occurrence of levels antibiotic resistance.
The Effect of Chronic Oral Desipramine on Capsaicin-Induced Allodynia and Hyperalgesia: A Double-Blinded, Placebo-Controlled, Crossover Study

The tricyclic antidepressants are often used for the treatment of neuropathic pain. In this study, we evaluated one of these drugs on human cutaneous experimental pain. A randomized, double-blinded, placebo-controlled, crossover design methodology was conducted. Subjects participated in 2 14-day study sessions separated by a 7-day washout period. One session was with desipramine and one with placebo. At baseline, Day 7, and Day 15, quantitative sensory testing was performed to thermal and mechanical stimuli. On Day 15 only, intradermal capsaicin was injected on the volar aspect of the forearm followed by an assessment of pain and hyperalgesia. Oral desipramine had no significant effect on acute sensory thresholds, pain, secondary hyperalgesia, or flare response induced by intradermal capsaicin. Mean peak plasma levels of desipramine were within the therapeutic range for the treatment of depression. This study further supports a lack of effect of the tricyclic antidepressants on acute nociception and experimentally-induced secondary hyperalgesia.
Password Capabilities Revisited

With reference to a distributed system consisting of nodes connected by a local area network, we present a new formulation of the password capability paradigm that takes advantage of techniques of symmetric-key cryptography to represent password capabilities in memory. We assign a cryptographic key to each application; the password capabilities held by a process of a given application are encrypted by using the key of this application. Passwords are associated with object types; two or more objects of the same type, which are allocated in the same node, share the same set of passwords. Our password capability paradigm preserves all the advantages concerning simplicity in access right representation and administration (distribution, verification, review and revocation) that characterize the classical paradigm, while keeping the memory requirements for password storage low, and solving the problems connected with password capability stealing and forging.
Data Compression in Smart Distribution Systems via Singular Value Decomposition

Electrical distribution systems have been experiencing many changes in recent times. Advances in metering system infrastructure and the deployment of a large number of smart meters in the grid will produce a big volume of data that will be required for many different applications. Despite the significant investments taking place in the communications infrastructure, this remains a bottleneck for the implementation of some applications. This paper presents a methodology for lossy data compression in smart distribution systems using the singular value decomposition technique. The proposed method is capable of significantly reducing the volume of data to be transmitted through the communications network and accurately reconstructing the original data. These features are illustrated by results from tests carried out using real data collected from metering devices at many different substations.
Grid interaction of DG units with a modified mixed cascade flying capacitor multicell inverter

Grid interaction of DG units with a novel hybrid flying capacitor multicell converter which is suitable for hybrid systems, is presented in this paper. Multicell inverters have important advantages which make them a flexible solution for medium voltage/high power applications such as: lower rating of switches and lower output voltage THD. Proposed configuration of multicell inverter requires less number of switches in comparison with typical flying capacitor multicell inverters. Simulation results using MATLAB software are demonstrated to confirm theory.
The Contour Deformation Method for Calculating the High-Frequency Scattered Field by the Fock Current on the Surface of the 3-D Convex Cylinder

In this paper, the high-frequency diffracted waves like the creeping waves are comprehensively analyzed by the Fock currents. On invoking the contour deformation method, the highly oscillatory Fock currents are efficiently calculated. Furthermore, the workload for the calculation of Fock currents is frequency-independent. To capture the high-frequency wave physics phenomenon, the Fock current is separated into the classical physical optics (PO) current and the nonuniform (NU)-Fock current along the shadow boundary and in the deep shadow region. To calculate the highly oscillatory scattered wave fields from the Fock current, quadratic approximations of the phase functions in the integrand are adopted. On invoking the numerical steepest descent path (NSDP) method, the scattered wave fields are efficiently calculated with frequency-independent computational effort and error controllable accuracy in each frequency-independent segment. Meanwhile, the high-frequency creeping wave coming from the NU-Fock current is efficiently captured by the NSDP method. Numerical results for the Fock currents, the high-frequency NU-diffracted and scattered far fields on the convex cylinders are given to validate the efficiency of the proposed method. Furthermore, the contour deformation method for computing the Fock currents offers a clear physical picture for the high-frequency wave fields on the convex scatterer.
Sensory and Motor Characterization in the Postnatal Valproate Rat Model of Autism

Although autism is diagnosed according to three core features of social deficits, communication impairments, and repetitive or stereotyped behaviors, other behavioral features such as sensory and motor impairments are present in more than 70% of individuals with autism spectrum disorders (ASD). Exposure of rat pups to the teratogen valproate during sensitive periods of brain development has been shown to elicit behavioral features associated with autism diagnosis and has been proposed as a valid animal model of the disorder. The purpose of this study was to characterize sensory and motor performance in rats postnatally treated with valproate. Thirty-four rat pups were injected with either valproate (150 mg/kg) or saline on postnatal days 6–12. Auditory and tactile startle as well as auditory sensory gating was assessed during both the juvenile and adolescent stages of development; motor testing was conducted during late adolescence and included a sunflower seed eating task and a vermicelli handling task. Valproate-treated rats were underresponsive to auditory stimuli, showed deficits in auditory sensory gating, and demonstrated impairments in motor speed and performance. These findings suggest that postnatal valproate treatment elicits sensory and motor features often seen in individuals with ASD. Further, the hyposensitivity seen in postnatally valproate-treated rats contrasted with hypersensitivity previously reported in prenatally valproate-exposed rats. This suggests that timing of teratogenic exposure during early brain development may be important to consider when investigating the neurobiological basis of sensorimotor impairments in ASD.
As estratégias das indústrias de farinha de trigo e de massas alimentícias do Rio Grande do Sul

A pesquisa identifica as estrategias praticadas nas industrias de farinha de trigo e de massas alimenticias do Rio Grande do Sul no ano de 2007. E uma pesquisa exploratoria baseada nas estrategias competitivas de Porter (1980) e de Mintzberg (1988), que utiliza na analise dados de questionarios respondidos pelas empresas. Os resultados da pesquisa mostram que entre as estrategias de Porter, destacam-se a de custos mais baixos, na industria de farinha de trigo, e a diferenciacao, na industria de massas. Entre as tipologias de Mintzberg, a qualidade do produto e considerada pelos gestores como sendo o grande diferencial competitivo nas duas industrias.
Tensor based dimension reduction for polarimetric SAR data

With the development of target decomposition theorems for polarimetric synthetic aperture radar (PolSAR) data, various informative polarimetric descriptors could be obtained. The redundancy among these descriptors poses a hindrance to accurate classification. In this paper, we propose a tensor-based dimension reduction technique, which aims to obtain a lower-dimensional intrinsic feature set from the high-dimensional polarimetric manifold. We combine 48 polarimetric features together and formulate them as a third-mode tensor. The spatial information is taken into consideration for feature reduction. Experimental results in comparison with principal component analysis (PCA), independent component analysis (ICA) and Laplacian Eigenmaps (LE) proves its effectiveness.
Clinical Practice Guidelines for the Prevention and Treatment of Mucositis

Dorothy M. Keefe, MD Mark M. Schubert, DDS, MSD Linda S. Elting, DrPH Stephen T. Sonis, DMD, DMSc Joel B. Epstein, DMD, MSD Judith E. Raber-Durlacher, DDS, PhD Cesar A. Migliorati, DDS, PhD Deborah B. McGuire, PhD, RN Ronald D. Hutchins, MSLS Douglas E. Peterson, DMD, PhD for the Mucositis Study Section of the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology
Experimental investigation of the impact of SEM chamber conditions on the contact resistance of in-situ nanoprobing

This paper reports the experimental investigation of the impact of vacuum chamber conditions (cleanliness level and vacuum pressure) of scanning electron microscopy (SEM) on the contact resistance of two-point in-situ nanoprobing. Using two typical types of conductive nanoprobe, two-point electrical nanoprobing is performed on silicon nanowires, during which changing trends of the nanoprobing contact resistance with the levels of SEM chamber cleanliness and vacuum pressure are quantified. This experimental results can serve as a guideline to evaluate electrical contacts of nanoprobing and instruct how to reduce the contact resistance in SEM-based two-point nanoprobing applications.
Interlobe communication in multiple calcium‐binding site mutants of Drosophila calmodulin

We have generated mutants of Drosophila calmodulin in which pairs of calcium‐binding sites are mutated so as to prevent calcium binding. In all sites, the mutation involves replacement of the —Z position glutamate residue with glutamine. Mutants inactivated in both N‐terminal sites (B12Q) or both C‐terminal sites (B34Q), and two mutants with one N‐ and one C‐terminal site inactivated (B13Q and B24Q) were generated. The quadruple mutant with all four sites mutated was also studied. UV‐difference spectroscopy and near‐UV CD were used to examine the influence of these mutations upon the single tyrosine (Tyr‐138) of the protein. These studies uncovered four situations in which Tyr‐138 in the C‐terminal lobe responds to a change in the calcium‐binding properties of the N‐terminal lobe. Further, they suggest that N‐terminal calcium‐binding events contribute strongly to the aberrant behavior of Tyr‐138 seen in mutants with a single functional C‐terminal calcium‐binding site. The data also indicate that loss of calcium binding at site 1 adjusts the aberrant conformation of Tyr‐138 produced by mutation of site 3 toward the wild‐type structure. However, activation studies for skeletal muscle myosin light chain kinase (SK‐MLCK) established that all of the multiple binding site mutants are poor activators of SK‐MLCK. Thus, globally, the calcium‐induced conformation of B13Q is not closer to wild type than that of either the site 1 or the site 3 mutant. The positioning of Tyr‐138 within the crystal structure of calmodulin suggests that effects of the N‐terminal lobe on this residue may be mediated via changes to the central linker region of the protein.
Lateral rectal ligaments contain important nerves

The contents of the so-called lateral rectal ligaments are defined differently in surgical and anatomical texts. In surgical texts the middle rectal arteries are referred to as the main structures within them1–3. In contrast, the meticulous anatomical work by Sato and Sato4 has shown that arteries are found in only about 20 per cent of cadaver dissections, whereas nerve branches from the pelvic plexuses, also called the neurovascular bundles, are uniformly constant structures within the ligaments. This view of the lateral ligaments as important nervecontaining structures is supported by clinicophysiological results after sphincter-saving surgery reported in the Japanese literature5,6. The autonomic nerve supply of the lower rectum has been postulated to arise from the pelvic side wall plexuses4,7. The close relationship of the ligaments to the pelvic plexuses, which contain merging sympathetic and parasympathetic nerve fibres, makes the dissection of the ligaments crucial in maintaining genitourinary function8,9. However, Enker et al.10 recently considered the ligaments to be structures that are surgically developed by medial traction during operation. This view has been further established by the same group after cadaveric studies11. The objective of this investigation was to study the nervous contents of the lateral rectal ligaments in a surgical series of patients.