Miracle-dz/UniFAR-FTUs huggingface dataset:
İn vivo floresan görüntüleme ve in vivo uygulamalarda kullanılan florofor bileşikler

Bir dalga boyundaki isikla uyarildiginda, daha uzun dalga boyunda isik ureten maddelere (molekullere/bilesiklere) floresan maddeler; bu olguya floresan isima denir. Geleneksel olarak kultur ve hucre izlemelerinde kullanilan floresan isimaya dayali goruntuleme teknikleri, son on-yillarda in vivo izlemelerde de kullanilmaya baslanmistir. FLIM, FRET, FRI gibi in vivo goruntuleme duzenekleri cogunlukla kucuk laboratuvar hayvanlarina uygulanirlar ve ilgilenilen protein veya biyo-molekulun gercek zaman-mekanda in vivo goruntulerinin alinmasini olanakli kilarlar. Bu duzenekler genel olarak, hayvanin uzerine konacagi sahne, bir floresan uyarici isik kaynagi, gelen ve emisyon isik filtreleri, kamera aparati (CCD kamera) ve datalari alip analiz eden bir yazilim programi elemanlarindan olusmaktadirlar. Herhangi bir in vivo izleme sisteminde, oncelikle hedef protein ya bir dogal floresan reporter proteinle kaynastirilir ya da uygun gorulen floresan boya (florofor bilesik) ile kimyasal olarak isaretlenir; bundan sonra isaretli protein canli bunyede izlenir. Basarili bir in vivo izleme icin uygun floresan probun secilmesi cok onemlidir. In vivo uygulamalarda kullanilan floresan problar genel olarak hedef gozetmeyen problar, hedefli aktif problar, hedefli aktive edilebilen problar ve nano-partikuller seklinde siniflandirilabilirler. Bu konudaki teknolojinin ilerlemesi ve daha etkili floresan problarin kesfedilmesi floresan isimaya dayali in vivo izlemelerin daha yaygin olarak kullanilmalarina yol acacaktir. Bu izlemeler sayesinde hastaliklarin etiyoloji, prognoz ve tedavi surecleri hakkinda daha detayli bilgilere ulasilacagi ongorulmektedir. Bu derlemede floresan isimanin mekanizmasi, floresan isima prensibine dayali olarak calisan ve onemli gorulen in vivo goruntuleme sistemleri ve florofor bilesikler hakkinda bilgi verilmesi ve konuyla ilgili onemli calismalarin gozden gecirilmesi hedeflenmistir.
Ultralow Thermal Resistance across the Solid–Ionic Liquid Interface Caused by the Charge-Induced Ordered Ionic Layer

The understanding and regulation of thermal transport across the solid-liquid interface, especially the electrical double layer (EDL) formed by ionic liquid (IL), is significant for the reasonable design of the efficient thermal dissipation capabilities in the field of chemical engineering. In the present work, by large-scale molecular dynamics simulation method, we reveal that rather than the strong solid-liquid interaction, the atomic structure of EDL dominates the entire interfacial thermal transport across solid-IL interfaces. The simulation results show that as the surface charge increases, interfacial thermal resistance (ITR) will decrease in two stages, sharp firstly and then slowly. Two-dimensional structure factors, geometry state of cation, and solid-liquid interfacial energy for different surface charge demonstrate that the evaluation of EDL agrees well with the trend of ITR. Furthermore, the vibrational spectrum and frequency-dependent heat flow also indicate that the high ordered EDL will enh.
Anticancer effect of the ethanol extract of Annona muricata L. leaves and fruit in cancer induced mice

Objective: The present study was carried out to evaluate the anticancer property of ethanol extract of Annona muricata L. Leaves and fruit against Ehrlich ascites carcinoma in Swiss albino mice. Materials and Methods: The experimental animals were divided into five groups. Group I: (Normal group) Normal mice were received (0.2 ml Saline), Group II: (Cancer group) 20 mice were intraperitoneally received EAC cells (2×10cells/mouse I.P.), Group III: (EAC + leaves extract) 20 mice were orally treated after 48 hours from injection of EAC cell with a dose of 200mg/kg body weight daily for 9 consecutive days, Group IV: (EAC + fruit extract) mice were orally treated after 48 hours from injection of EAC cell with a dose of 200mg/kg body weight daily for 9 consecutive days, Group V: (EAC+ cisplatin), 20 mice were intraperitoneally treated with cisplatin after 48 hours from injection with EAC at a daily dose of 2 mg/kg body weight for 9 consecutive days. Total experimental period was 11 days, after 24 h from the last dose, 8 mice in each group were anesthetized by diethyl ether and sacrificed for the histopathological examination of liver tissue. Results: The extracts showed residual tumor growth on the surface of the liver without infiltration and mild inflammation. Conclusion: From the result it can be found that the ethanol extract of Annona muricata L. Leaves and fruit showed anticancer effect when compared to the tumor group.
East meets West: Evaluations of the potential role of early life conditions on adult ovarian steroid levels in Mongolian and German women

Interaction networks shaped by social processes constitute the substrate on which various phenomena of interest to human biology occur, for example, epidemics, diffusion of health information, and the exertion of social influence related to health. Understanding the structure of network formation is thus crucial to our understanding of how relational human interactions mediate key biosocial outcomes. Research in this area has been hampered by a lack of high-quality data on the formation and structure of contact networks. Using Wireless Sensor Network (WSN) technology, measured the temporal dynamics of close-proximity interaction networks during a typical school day in a high school in the San Francisco Bay Area. Participants wore small wireless sensors which send and receive radio signals to and from other sensors nearby. This technology allowed us to collect dynamic contact network data with unparalleled precision. At a 94% coverage, we collected 762,868 CPIs at a maximal distance of 3 meters among 788 individuals. The data revealed a high density network with typical small world properties and a relatively homogenous distribution of both interaction time and interaction partners among subjects. Computer simulations of the spread of an influenza-like disease on the weighted contact graph are in good agreement with absentee data during the most recent influenza season. Analysis of targeted immunization strategies suggested that contact network data are required to design strategies that are significantly more effective than random immunization. Immunization strategies based on contact network data were most effective at high vaccination coverage
XPS and IR Spectroscopic Studies of Titanyl and Vanadyl Complexes with Etioporphyrin II

aIvanovo State University of Chemistry and Technology, 153000 Ivanovo, Russia bMIREA – Russian Technological University, 119571 Moscow, Russia cKotel’nikov Institute of Radio Engineering and Electronics RAS, 141190 Fryazino, Russia dInstitute of Solid State Physics RAS, 142432 Chernogolovka, Russia eLLC NPF Fire Protection Engineering Laboratory, 606016 Dzerzhinsk, Russia @Corresponding author E-mail: valeryfom@rambler.ru
Current Status of Bovine Tuberculosis in Ogbomoso Area of Oyo State

2 Abstract: This study investigated Bovine tuberculosis in 17676 cattle slaughtered in "Attenda" abattoir of Ogbomoso area of Oyo state between November 2004 - October 2005. The granulomatious lesions in lung, lymphnode (mediastinal, bronchial regrophanygeal and messerteric) liver, spleen and intestine were observed in 97 cattle out 17676 and they were positive by Ziehl - Neelsen (acid-fast) technique. There was no significant difference at P>0.05 between percentage status in both dry and rainy season with 0.54% and 0.57% respectively, also in organ and sex distribution in both male and female. Of the 97 tuberculosis lesions found 57 were found in males while 44 occurred in female. The most affected organs were lungs at 49 (48.51%) and lymphnode 26 (25.74%) while the least affected organs were spleen and small intestine 4 (3.96%) and oesophagus and diaphragmatic muscles were not affected at all (0.0%)respectively while. The conclusion drawn was that overall percentage status of 0.55% was observed in cattle slaughtered in Ogbomoso area of Oyo state and this is of epidemiological importance to both human medics, veterinarian and for public health.
Characteristics of leaching agents for heavy metal extraction and safe utilisation of pig farm biogas residues

The continuous development of biogas engineering in recent years has been accompanied by an increasing number of biogas-residue types in the environment. The existence of various heavy metal elements in biogas residues, particularly excessive amounts of zinc and copper in pig farm biogas residues, hinders their safe utilisation. Several studies have focused on an effective composition for biogas residues or on their effects on soil and plants. However, few investigations regarding the removal of harmful substances from biogas residues have been conducted. The characteristics of heavy metals leached from pig farm biogas residues using eight types of leaching agents were analysed in this study. It is expected that, based on this study, different uses for biogas residues can be developed under the premise of security. The results showed that the most suitable extractant of heavy metals from pig farm biogas residues was EDTA2Na. The leaching rates increased over time. The leaching rates of copper and zinc after 2 h were 21.91% and 48.66%, respectively. After being leached for 2 h by EDTA-2Na, the concentration of zinc met the requirements for moderate alkaline soil, according to the Control Limits against Harmful Substances in Composts for Agricultural Use (DB44/T 361-2006) standard.
Antibacterials From Plants of the Tropical Rain Forests of Borneo

The tropical rain forests of Borneo are global hotspots for plant biodiversity which also harbour diverse chemical compounds and play an important role in folk medicine. Such phytochemicals have potential medicinal properties including as antibacterials. The search for new and novel antibacterials and resistance-modifying compounds is urgently required as the overuse or abuse of antibiotics has rendered many ‘last line of defence’ antibiotics ineffective. This study attempted to screen plant extracts from 5 selected plant families from Borneo for antibacterial activities. In addition to isolating and elucidating the structures of the compounds, bio-guided assay (broth dilution assay and agar dilution assay) were used to screen the plant extracts as well as the potency of the bioactive compounds isolated. Various chromatographic and spectroscopic techniques were employed to isolate the bioactive compounds from the extracts and to elucidate their structures respectively. Investigations were also undertaken to understand the mechanisms of action through various selected assays (accumulation, inhibition of biofim formation assay, and plate conjugation assays). This study led to the isolation of mainly phenolic compounds (e.g. xanthones, coumarins and styryllactones) but also some terpenoids (e.g. iridiod and diterpenes) and an alkaloid. They were either broad spectrum against different strains of both Gram-positive and Gram-negative and acid-fast bacilli or specific against one type of bacteria. Styryllactones and an alkyl benzoic acid isolated from Goniothalamus longistipetes exhibited broad-spectrum activities against Gram-positive, Gram-negative and acid-fast bacteria. Prenylated xanthones (STP10) isolated from Garcinia celebica gave the best activities against Gram-positive bacteria including the resistant strains with activities of between 1-4 µg/mL while STP10 also showed the best activities against Mycobacterium bovis BCG at 1.98 µg/mL This was followed by a diterpene (STP19) at 3.91 µg/mL while a styryllactone isomer (STP7), a pyranone (STP11) and a diterpene (STP18) all displayed an MIC of 7.81 µg/mL. Additionally, the diterpene (STP19) showed the best activities in inhibiting both bacterial efflux pumps and Inhibition of biofim assay. The alkyl benzoic acid (STP6) also inhibited the transfer of the bacterial plasmid pKM101 in plate conjugation assay with a 70% reduction. One of the styryllactones (STP8) screened exhibited the best activities against liver cancer (Hep G2) cell lines with IC50 at 0.986 µg/mL All the bioactive compounds followed the Lipinski’s rule of 5 for druglikeness.
Biofabrication of Silver nanoparticles using Cocculus hirsutus leaf extract and their antimicrobial efficacy

There is an increasing demand for the easily administered dosage forms and oral routes of drug administration have wide acceptance upto 50-60% of total dosage forms. The oral fast dissolving systems are defined as oral drug delivery systems that dissolve or disintegrate within a few seconds to a few minutes of placement in the mouth and that do not require water to aid swallowing. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-disintegrating tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed orally disintegrating tablets, as they may take up to a minute to completely disintegrate. Oral delivery is currently receiving the highest standards. Achieving the highest standards in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Fast- or mouth dissolving OR Orally disintegrating tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water.
Effect of Indomethacin on the Peritoneum of Rabbits on Peritoneal Dialysis

We studied the ultrastructural changes induced by intraperitoneal indomethacin on the visceral peritoneum of rabbits treated by peritoneal dialysis. We observed two outstanding effects: a) an increase in the number and size of endothelial vesicles and b) an almost complete disappearance of the endothelial intercellular spaces. The mechanisms of these changes are discussed.
Platelet-rich fibrin and its application in periodontics: a review of literature

La fibrina rica en plaquetas (FRP) es un concentrado plaquetario de segunda generacion que nos brinda, en un coagulo o membrana, gran cantidad de factores de crecimiento, leucocitos y citoquinas que se obtienen mediante la centrifugacion de sangre autogena. Su facil preparacion y manipulacion a diferencia de otros preparados plaquetarios hacen que pueda ser usada en la practica clinica diaria. La presente revision bibliografica tiene como objetivo describir las propiedades biologicas y las aplicaciones clinicas de la FRP en la cirugia mucogingival (cobertura radicular) y en el levantamiento del piso del seno maxilar.
HPLC analysis of extracts of fresh petals of Papaver Rhoeas l.

Papaver rhoeas L. (Papaveraceae) is an annual grass native to many regions of the world, which is known to possess several pharmacological activities. It is also known that represent a rich source of anthocyanins. In this study, the content of the anthocyanin was determined in the examined various extracts of fresh petals by HPLC analysis. The most represented anthocyanins in the extracts of Papaver rhoeas L. are delphinidin-3-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-rutinoside, peonidin-3-O-glucoside, petunidin-3-O-glucoside, petunidin-3-acetylglucoside, and delphinidin-3-p-coumaroylglucoside. Acyl derivatives of anthocyanins in the water extract have not been identified. By comparing the contents of individual anthocyanins, the glycosides (polar) are better extracted with 50% alcohol solution, and their acyl derivatives are better extracted with pure alcohol. The water solution is the least suitable for anthocyanin extraction.
Effect of Processing Conditions on the Quality of Wheat Protein

Wheat protein determines the biochemical and rheological properties of most wheat products. The final product depends critically upon the balance between different ratios of proteins that interact with each other through various processing methodologies. Protein is the most substantial component of our intake. As we belongs to Asia, wheat is enriched source of protein for us. Excessive amount of protein is found in wheat grain as compared to wheat flour. Wheat grains is transformed into variety of food products by enduring various food processing techniques. Nutritional quality is been correlatively effected by milling. Cell wall lysing in this process inflate the nutrients whereas it result in polysaccharide by stripping off wheat nutritional layers. Solubility of wheat protein rises through mixing which is further essential in dough kneading. Structural and functional properties of proteins is affected upon heating. Proteins became denature through heating and shearing during extrusion.
Quality indicators in the treatment of acute ischemic stroke

Cerebrovascular diseases are a global medical and social issue because of the high morbidity, disability and mortality they cause. WHO announces 15 million new ischemic strokes per year globally, with 5 million associated deaths and 5 million patients left permanently disabled. Thrombolysis (TL) with tissue plasminogen activator (rt-PA) is currently an approved differentiated pharmacotherapeutic treatment of ischemic stroke (IS) in its acute phase. There is irrefutable evidence of better health results and efficient clinical management of ischemic strokes within an integrated therapeutic approach as a key factor for improving the functional outcome in stroke patients. Quality is one of the most widely discussed issues in the theory and practice of disease management. Strict compliance with the standards for ischemic stroke treatment is an indicator of high quality patient management.
CLASS clarification: reaffirms the medical importance of the analyses and results

From BMJ USA 2002;September:522 We appreciate the opportunity to correct the inaccuracies in the article by Juni et al,1 which appear to be based on an incomplete understanding of the CLASS design, data, and statistical issues. Contrary to the editorial's assertions, there were no post hoc changes in the study design or the outcome definitions. The CLASS authors reviewed all the data and decided the 6-month analyses were most appropriate for initial publication,2 while the FDA chose 9-month data as most appropriate for a recent label change.3 Despite differing medical judgment for the time interval that best reflected the data, and contrary to the BMJ editorial allegations, the conclusions were similar. CLASS was a single study with the objective of comparing the rate of ulcer complications with celecoxib versus traditional NSAIDs. The need for two protocols was prespecified to ensure blinding of study medications. One protocol included celecoxib 400 mg BID and ibuprofen 800 mg TID; the other included celecoxib 400 mg BID and diclofenac 75 mg BID. Aside from this difference and the inclusion of quality of life measures in one protocol, the protocols were …
Estimation of blood alcohol content with bioimpedance spectroscopy

Alcohol consumption prior to driving a vehicle is a serious problem and currently the second most common cause of fatal accidents. The gold standard to assess Blood Alcohol Content (BAC) in the evaluation of fitness to drive is the Alcohol Dehydrogenase (ADH) method, using a blood sample obtained from the driver. In daily practice, however, breath alcohol is measured, even though it is less reliable compared with the ADH method. This study examines the feasibility of using bioimpedance as a measure for BAC. For this, Bioimpedance Spectroscopy (BIS) measurements were made in 12 healthy males while they were drinking alcohol, until reaching a BAC of 0.8%. A reference group of 9 healthy individuals drank the same amount of water. In the group drinking alcohol the extracted parameters showed a trend towards higher impedance with increasing alcohol intake; comparison of the extracellular resistance Re at the beginning and the end of the trials, these values showed a significant change (p = 0.042). In contrast, the reference group showed no significant change. In addition, the area under (ROC) curves for Re changes show good detection capabilities for 0.3%, 0.5% and 0.8%. Therefore, under certain conditions, BIS can be used to measure BAC with high specificity and sensitivity.
Myocardial deformation in African hypertensive patients with heart failure: an analysis using speckle tracking echocardiography

II DEDICATION . V ACKNOWLEDGEMENTS . VI TABLE OF CONTENTS . i LIST OF FIGURES . v LIST OF TABLES . vi NOMENCLATURE . vii 1.0 INTRODUCTION . 1 1.1 HYPERTENSIVE HEART DISEASE . 1 1.1.1 HYPERTENSION INDUCED HEART FAILURE . 3 1.2 SPECKLE TRACKING ECHOCARDIOGRAPHY . 5 1.2. 1 STRAIN . 5 1.2. 2 LEFT VENTRICULAR TWIST . 8 1.2. 3 LV STRAIN IN HYPERTENSION . 11 1.2. 4 LV TWIST IN HEART FAILURE . 12 1.3 BIOMARKERS IN HYPERTENSIVE HEART DISEASE AND MYOCARDIAL DEFORMATION . 15 1.4 IMPLICATIONS . 26 -
Organic Sensitizers for High Efficiency Dye-Sensitized Solar Cells

i DEDICATION . ii ACKNOWLEDGEMENTS . iii TABLE OF CONTENTS . iv LIST OF FIGURES . vi LIST OF TABLES . xi LIST OF SCHEMES. xiii CHAPTER 1: INTRODUCTION TO ENERGY CONSUMPTION. 1 CHAPTER 2: A STABLE PANCHROMATIC GREEN DUAL ACCEPTOR, DUAL DONOR ORGANIC DYE FOR DYE-SENSITIZED SOLAR CELLS IN DSCS. 6 CHAPTER 3: MOLECULAR ENGINEERING OF NEAR INFRARED ABSORBING THIENOPYRAZINE DOUBLE DONOR DOUBLE ACCEPTOR ORGANIC DYES FOR DYE-SENSITIZED SOLAR CELLS . 33 CHAPTER 4: QUINOXALINE-BASED DUAL DONOR, DUAL ACCEPTOR ORGANIC DYES FOR DYE-SENSITIZED SOLAR CELLS . 70 CHAPTER 5: DONOR−ACCEPTOR−DONOR THIENOPYRAZINES VIA Pd-CATALYZED C−H ACTIVATION AS NIR FLUORESCENT MATERIALS. 87 CHAPTER 6: TOWARD TIGHTLY BOUND CARBOXYLIC ACID-BASED ORGANIC DYES FOR DYE-SENSITIZED SOLAR CELLS . 117 CHAPTER 7: IODINE BINDING WITH THIOPHENE AND FURAN BASED DYES FOR DSCS. 142 CHAPTER 8: OVERALL CONCLUSIONS. 172 REFERENCES . 174 LIST OF APPENDICES . 187 APPENDIX A. ADDITIONAL INFORMATION FROM CHAPTER 2 . 188 APPENDIX B. ADDITIONAL INFORMATION FROM CHAPTER 3 . 200 APPENDIX C. ADDITIONAL INFORMATION FROM CHAPTER 4 . 207
ACUTE PANCREATITIS IN A PACIENT WITH CHOLEDOCHOLITHIASIS TREATED BY ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY. CASE REPORT

Methods and material: We will discuss the case of a patient TA, 69 years old, with known history of biliary colic, biliary lithiasis (ultrasonography), who underwent ERCP for choledocholithiasis diagnosed. Anamnesis, clinical exam and laboratory investigations lead to the diagnosis of acute pancreatitis. Results: The patient is assigned to surgery. Cloudy serosanguinous fluid and pancreatic necrosis areas are found. The evolution is favorable with improved general and biological state. The patient was discharged surgically healed. Conclusion: ERCP can be complicated by pancreatitis, even in the hands of an experienced doctor. Severe acute necrotico- hemorrhagic or supurative pancreatitis requires delayed emergency surgery, after complex patient stabilization.