Miracle-dz/UniFAR-FTUs huggingface dataset:
Age-Related Dysfunction in Lung Barrier Function in Health and Disease Dysregulated Nox 4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury

Palumbo S, Shin Y-J, Ahmad K, Desai AA, Quijada H, Mohamed M, Knox A, Sammani S, Colson BA, Wang T, Garcia JG, Hecker L. Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol 312: L297–L308, 2017. First published January 6, 2017; doi:10.1152/ajplung.00305. 2016. —Acute respiratory distress syndrome (ARDS) is a devastating critical illness disproportionately affecting the elderly population, with both higher incidence and mortality. The integrity of the lung endothelial cell (EC) monolayer is critical for preservation of lung function. However, mechanisms mediating EC barrier regulation in the context of aging remain unclear. We assessed the severity of acute lung injury (ALI) in young (2 mo) and aged (18 mo) mice using a two-hit preclinical model. Compared with young cohorts, aged mice exhibited increased ALI severity, with greater vascular permeability characterized by elevated albumin influx and levels of bronchoalveolar lavage (BAL) cells (neutrophils) and protein. Aged/injured mice also demonstrated elevated levels of reactive oxygen species (ROS) in the BAL, which was associated with upregulation of the ROS–generating enzyme, Nox4. We evaluated the role of aging in human lung EC barrier regulation utilizing a cellular model of replicative senescence. Senescent EC populations were defined by increases in -galactosidase activity and p16 levels. In response to lipopolysaccharide (LPS) challenge, senescent ECs demonstrate exacerbated permeability responses compared with control “young” ECs. LPS challenge led to a rapid induction of Nox4 expression in both control and senescent ECs, which was posttranslationally mediated via the proteasome/ubiquitin system. However, senescent ECs demonstrated deficient Nox4 ubiquitination, resulting in sustained expression of Nox4 and alterations in cellular redox homeostasis. Pharmacological inhibition of Nox4 in senescent ECs reduced LPS-induced alterations in permeability. These studies provide insight into the roles of Nox4/senescence in EC barrier responses and offer a mechanistic link to the increased incidence and mortality of ARDS associated with aging.
Should You Find out what Motivates Your Employees before They Run Away

Employee motivation is vital to the future success of the organizations because if it is identified correctly, managers can step aside the high costs associated with turnover. While the competition is steady with other companies to attract and to retain workers to meet the demand of the consumers, the management must gain a better understanding of what motivates their workers in order to overtake the high costs associated with turnover; managers must attempt to understand what motivates their staffs. [1] Therefore; employee motivation is an important topic for the organizations. This study desires to provide the practitioners in the aircraft industry and the comparisons of employee’s motivation and goals.
The Role of Trust as an Informal Mechanism in the Management Control System of Performance Effectiveness

Performance is a variable explaining the effectiveness of internal control systems that managed based on management accounting information and functions. There are some aspects of behavior that remain unexplained in understanding the effectiveness of the performance of organizations and individuals affected by the data and accounting functions. In addition, social mechanisms such as culture, honesty, group identification and trust play an important role in mitigating agency problems. This study aims to investigate what and how the role of trust in organizational performance is. It develops and tests a conceptual relation model between trust and performance through organizational commitment and job satisfaction. It also examines contextual factors in the form of cognitive orientation of the conceptual model that has been built. The data were collected by using questionnaire-based survey method for the employees based on the criteria of having direct supervisors and directly responsible for them, and a minimum work period of one year. They were analyzed using SEM PLS. It shows that organizational commitment mediates the positive relationship between trust and job satisfaction. The positive relationship between trust and performance is mediated by organizational commitment and job satisfaction. It also shows that cognitive orientation influences the relationship between job satisfaction and performance. This study contributes to the management accounting literature, that is, a conceptual relationship model of trust to performance in the realm of empirical research
European Heart Journal – Quality of Care & Clinical Outcomes launched in July The emergence of treatments that improve cardiovascular outcomes has triggered a new field of research

Executive Director of Interventional Cardiovascular Programs at the Brigham and Women’s Hospital Heart & Vascular Center, and Professor of Medicine at Harvard Medical School, Dr Deepak L. Bhatt, MD, MPH, FACC, FAHA, FSCAI, FESC, has strong research interests in the realms of stenting, acute coronary syndromes, preventive cardiology, antiplatelets, anticoagulants, lipid-modifying therapy, carotid intervention, peripheral artery disease, and transcatheter aortic valve replacement (TAVR). An advocate of bringing rigorous randomized clinical trial methodology to areas where it has not traditionally been used, he is also the editor of a number of prominent publications and a highly-cited author.
Smart mechanosensing machineries enable migration of vascular smooth muscle cells in atherosclerosis-relevant 3 D matrices † Running title : Mechanosensing machineries in 3 D matrices

At the early stage of atherosclerosis, neointima is formed due to the migration of vascular smooth muscle cells (VSMCs) from the media to the intima. VSMCs are surrounded by highly adhesive 3D matrices. They take specific strategies to cross various 3D matrices in the media, including heterogeneous collagen and mechanically-strong basement membrane. Migration of VSMCs is potentially caused by biomechanical mechanism. Most in vitro studies focus on cell migration on 2D substrates in response to biochemical factors. How the cells move through 3D matrices under the action of mechanosensing machineries remains unexplored. In this review, we propose that several interesting tension-dependent machineries act as “tractor”— posterior myosin II accumulation, and “wrecker” – anterior podosome maintaining, to power VSMCs ahead. VSMCs embedded in 3D matrices may accumulate a minor myosin II isoform, myosin IIB, at the cell rear. Anisotropic myosin IIB distribution creates cell rear, polarizes cell body, pushes the nucleus and reshapes the cell body, and cooperates with a uniformly-distributed myosin IIA to propel the cell forward. On the other hand, matrix digestion by podosome further promote the migration when the matrix becomes denser. Actomyosin tension activates Src to induce podosome in soft 3D matrices and retain the podosome integrity to steadily digest the matrix.
EVIDENCE THAT EFFEROCYTOSIS IS IMPAIRED IN ATHEROSCLEROSIS

Circulation. 2017;135:476–489. DOI: 10.1161/CIRCULATIONAHA.116. 025684 476 Yoko Kojima, MD, PhD Irving L. Weissman, MD Nicholas J. Leeper, MD ABSTRACT: The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque. Although apoptotic cells are cleared quickly in almost all other tissue beds, their removal appears to be significantly impaired in the diseased blood vessel. Emerging evidence indicates that this phenomenon is caused by a defect in efferocytosis, the process by which apoptotic tissue is recognized for engulfment by phagocytic cells such as macrophages. Genetic and experimental data suggest that efferocytosis is impaired during atherogenesis caused by dysregulation of so-called eat me ligands, which govern the edibility of cells undergoing programmed cell death. The following is a summary of recent data indicating that efferocytosis is a major unappreciated driver of lesion expansion but also a reversible defect that can potentially be targeted as a means to prevent plaque progression.
Priority Frequency and dynamics of ex-vivo AML-culture initiating cells reflect patients’ outcome.

: (188 out of 250) Acute Myeloid Leukemia (AML) is sustained by a sub-population of rare Leukemia initiating cells (LICs) detected in the xenograft assay by their capacity to self-renew and to generate non-LICs in vivo . The xenotransplantation model captures functional properties of LICs that have clinical prognostic value. However, the long duration of this in vivo assay has hampered its use as a prognostic tool. Here, we show using an ex vivo co-culture system, that intermediate and poor risk AML patient samples at diagnosis have a 5 to 7 times higher frequency of Leukemic-Long Term Culture-Initiating cells (L-LTC-ICs) compared to the good risk group. We defined a Fluorescence Dilution Factor (FDF) parameter that monitors sample proliferation over 1 week and established a strong correlation of this parameter with the L-LTC-IC frequency. A higher FDF was found for poor prognostic AMLs or for samples capable of engrafting NSG mice compared to good risk AMLs or non-engrafters. Importantly, FDF could classify normal karyotype-intermediate risk patients into 2 groups with a significant difference in their overall survival, thus making this non-genetic and non-in vivo approach a new clinically relevant tool for a better diagnosis of AML patients.
AND METHODS HBeAg Standard Two vials of first WHO International Standard ( IS ) for HBeAg

Background & Aim: Hepatitis B viruse-antigen (HBeAg) is an affordable viral marker to assess viral replication kinetics and response to antiviral therapy. In the absence of confirmatory assays, discrepant or false-positive HBeAg results are resolved by screening for other HBV markers. We standardized an in-house HBeAg neutralization assay (HBeAg-NT) to confirm HBeAg in clinical samples. Methods: The performance and reliability of this assay were evaluated by first WHO International Standard for HBeAg (first WHO-IS HBeAg) from Paul Ehrlich Institute and clinical samples (n = 150) from chronic HBV carriers. Of these, 71 HBeAg-positive sera were used for HBeAgNT. Results: Concentrations spanning 0.25–10 U of first WHO-IS HBeAg and clinical samples (S/Co ranges from 1.00 to 10.00) were neutralized completely in the HBeAg-NT. Conclusions: HBeAg-NT is a simple, cost-effective, and reliable direct approach to confirm HBeAg in clinical samples which precludes the need for screening additional HBV markers in low resource settings. J. Clin. Lab. Anal. 00:1–4, 2016. © 2016 Wiley Periodicals, Inc.
Lipopolysaccharide of Aggregatibacter actinomycetemcomitans upregulates inflammatory cytokines

Mizutani H, Ishihara Y, Izawa A, Fujihara Y, Kobayashi S, Gotou H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Kamei H, Kikuchi T, Yamamoto G, Mitani A, Nishihara T, Noguchi T. Lipopolysaccharide of Aggregatibacter actinomycetemcomitans up-regulates inflammatory cytokines, prostaglandin E2 synthesis and osteoclast formation in interleukin-1 receptor antagonist-deficient mice. J Periodont Res 2013; 48: 748–756. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Species-Mediated Signaling Mice by Mitochondrial Reactive Oxygen Deficient - Aggravated Arthritis in IEX-1 Enhanced Th17 Differentiation and

CD4 + Th1 and Th17 cells both can cause autoimmune diseases, either alone or collaboratively, if left unchecked. However, what determines the dominant Th effector phenotype in a speciﬁc autoimmune disease remains poorly understood. Our present investigation shows that null mutation of IEX-1 promotes differentiation of Th17 cells but compromises the survival of Th1 cells. The differential effect gave rise to a greater number of Th17 cells, a higher level of IL-17 production, and more severe arthritis in IEX-1 knockout mice than in wild-type mice after immunizations with collagen. IEX-1 deﬁciency-facilitated Th17 cell differentiation was mediated by the increased formation of reactive oxygen species (ROS) at mitochondria following T cell activation, as suggested by marked inhibition of Th17 induction with ROS scavenger N -acetylcysteine or mitoquinone, a speciﬁc inhibitor for mitochondrial ROS production. Mitochondrial ROS augmented the expression of B cell-activating transcription factor, which may contribute to increased IL-17 production in the absence of IEX-1, in light of its importance in IL-17 transcription. The results demonstrate that mitochondrial ROS contribute signiﬁcantly to the dominant Th effector phenotype in autoimmunity in addition to the cytokine milieu. The Journal of Immunology , 2012, 189: 000–000.
CrossLang: the system of cross-lingual plagiarism detection

Plagiarism and text reuse become more available with the Internet development. Therefore it is important to check scientific papers for the fact of cheating, especially in Academia. Existing systems of plagiarism detection show the good performance and have a huge source databases. Thus now it is not enough just to copy the text “as is” from the source document to get the “original” work. Therefore, another type of plagiarism become popular — cross-lingual plagia-rism. We present a CrossLang system for such kind of plagiarism detection for English-Russian language pair. The key idea for Cross-Lang system is that we use the monolingual approach. We have a suspicious Russian document and English reference collection. We reduce the task to one language — we translate the suspicious document into English with the help of machine translation sys-tem. After this step we perform the subsequent document analysis. There are two main stages at this analysis: source retrieval stage and document comparison stage. Both of these stages are adapted for our task. At source retrieval stage we need to find the most relevant documents from collection for a given translated suspicious document. Therefore the algorithm is based on aggregation of semantically close words into word classes and thus handles the cases of reformulated passages. The following document comparison is based on phrase embeddings that are trained in unsupervised and semi-supervised regimes. We evaluate CrossLang on the existing and generated datasets. We demonstrate the performance of the whole approach. We integrate the CrossLang in Antiplagiat system (most popular and well-known plagiarism detection system in Russia and CIS) and provide technical characteristics. We also provide the analysis of the system performance.
Kinetics of relativistic electrons undergoing small recoils in periodic structures and matter

We developed a general method for evaluating the energy spectrum evolution of relativistic charged particles that have undergone small quantum losses, such as the ionization losses when the electrons pass through matter and the radiation losses in the periodic fields. These processes are characterized by a small magnitude of the recoil quantum as compared with the particle's initial energy. The 'detector' function for arbitrary recoil spectrum is derived in addition to the straggling function. These functions are determined by the average number of scattering events undergone by the particle over the length of the detector (ionization losses) or the periodic field and the specific spectrum of the recoil. Moments for both the straggling function and the detector function are derived. The minimum average number of recoils, above which both functions depend only upon the mean energy of recoil quantum, is estimated. The average of this number is about 10 recoil events.
Development Experience on the Design of a Wearable Mobile System

Wearable devices have emerged in the last years with new applications that provide user convenience. Healthcare, sports, safety are some examples of areas in which wearable devices have been used. This paper overviews wearable architectures found in the literature and presents a novel wearable for monitoring ecological environments. The wearable includes a Head-UP Display (HUD) assembled with Google Cardboard API and sensors connected to a development board. Our wearable device provides several functionalities such as distance measurement to objects and weather conditions monitoring. Camera and green lasers combined with a digital image processing algorithm are used to measure the distance to objects. We different development boards to build the system.
Lessons from Hurricane Katrina Storm Surge on Bridges and Buildings

The storm surge associated with Hurricane Katrina caused tremendous damage along the Gulf Coast in Louisiana, Mississippi, and Alabama. Similar damage was observed subsequent to the Indian Ocean tsunami of December 26, 2004. In order to gain a better understanding of the performance of engineered structures subjected to coastal inundation due to tsunami or hurricane storm surge, the writers surveyed damage to bridges, buildings, and other coastal infrastructure subsequent to Hurricane Katrina. Numerous lessons were learned from analysis of the observed damage, and these are reported herein. A number of structures experienced significant structural damage due to storm surge and wave action. Structural members submerged during the inundation were subjected to significant hydrostatic uplift forces due to buoyancy, enhanced by trapped air pockets, and to hydrodynamic uplift forces due to wave action. Any floating or mobile object in the nearshore/onshore areas can become floating debris, affecting structures in two ways: impact and water damming. Foundation soils and foundation systems are at risk from shear- and liquefaction-induced scour, unless designed appropriately.
3 THE MODELS : NEW TWO-DIMENSIONAL PACKING PROBLEMS

We present the transcript of the IFORS distinguished lecture delivered by the author on invitation of SOBRAPO and IFORS. The lecture concerned the development of an interdisciplinary research motivated by an application in mobile telecommunication systems, a project jointly developed by four research teams. The presentation follows the typical steps of a classical operations research study, and aims at reviewing the main theoretical and practical results that were obtained.
Glycerolipidome peculiarities of the smallest green picoeukaryote 8 Ostreococcus tauri 9

1Laboratoire de Biogenèse Membranaire, UMR 5200, CNRS, Université de Bordeaux BP81, F-33882 12 Villenave D'Ornon, France 13 2Rothamsted Research, Biological, Chemistry, Harpenden, AL5 2JQ, United Kingdom 14 3Laboratoire de Biologie Cellulaire et Végétale, UMR 5168 CNRS, CEA, INRA, Université Grenoble 15 Alpes, BIG, CEA-Grenoble, 38054 Grenoble, Cedex 9, France 16 §-Corresponding Author. 17 One sentence abstract. 18 Plastidial and non-plastidial structural lipids displayed distinctive and highly regulated fatty acid 19 patterns, exhibited features of distinct lineages and fueled the synthesis of highly unsaturated TAGs. 20
Inhibition by Cyclomarin A Structural Basis of Mycobacterial Protein Structure and Folding :

10.1074/jbc.M113. 493767 Access the most updated version of this article at doi: . JBC Affinity Sites Find articles, minireviews, Reflections and Classics on similar topics on the Alerts: When a correction for this article is posted • When this article is cited • to choose from all of JBC's e-mail alerts Click here http://www.jbc. org/content/288/43/30883.full. html#ref-list-1 This article cites 33 references, 4 of which can be accessed free at
Spatial and temporal covariation in the recruitment and abundance of Atlantic salmon populations in the Baltic Sea

Synchronous trends in the abundance of hatchery and wild Baltic salmon populations are examined using correlation analysis. The river catch of wild adult salmon, the recruitment of age 0+ wild salmon parr, and the recapture rate of tagged hatchery smolts are positively correlated among rivers in the Baltic Sea. The spatial correlation among populations is greater than reported for other anadromous salmonids. Baltic salmon populations have undergone low frequency, high amplitude changes in abundance during the past 200 years. Recent production levels have been supported largely by hatcheries. EVorts to conserve the remaining wild populations through fisheries regulation appear to be having a positive eVect on spawner abundance. 1999 International Council for the Exploration of the Sea
EFFECTIVE 3 D REGULARIZED XFEM FOR PULL-OUT OF STEEL BARS IN CONCRETE , BENDING AND SHEAR TESTS ON FRP-REINFORCED CONCRETE BEAMS

We present an effective three-dimensional tool for modeling the influence on the structural behavior of the mechanical behavior of the interface between steel bars and FRP plates glued to concrete beams. The proposed tool reproduces the pull out of the bars and the detachment of the FRP plates. Both opening and sliding of the interface between reinforcements and beam are accounted for. The tool is based on the regularized extended finite element method (XFEM) developed by the authors: the discontinuities are regularized and a mechanically consistent variational formulation is adopted. The considered cases range from the simulation of pull-out tests of steel rebars, to the simulation of single-lap tests in shear and three point bending tests in FRP-reinforced concrete beams.
FtsH facilitates proper biosynthesis of photosystem I in Arabidopsis 6 thaliana

5 FtsH facilitates proper biosynthesis of photosystem I in Arabidopsis 6 thaliana 7 8 Sari Järvi, Marjaana Suorsa, Luca Tadini, Aiste Ivanauskaite, Sanna Rantala, Yagut 9 Allahverdiyeva, Dario Leister and Eva-Mari Aro 10 11 Molecular Plant Biology, Department of Biochemistry, University of Turku, FI-20520, 12 Turku, Finland 13 14 Plant Molecular Biology (Botany), Department of Biology I, Ludwig-Maximilians15 Universität München (LMU), Großhaderner Straße 2, 82152 Planegg-Martinsried, Germany 16 17 One sentence summary: FtsH proteases assist biosynthesis of photosystem I 18 19 Author contributions: S. J., M.S., Y.A. and E. -M.A. designed the research. S.J., M.S., A.I., 20 L.T. and S.R. performed the research. S. J., M.S., D.L. , Y.A. and E. -M.A. analyzed the data 21 and wrote the article. 22 23 Funding: This research was supported by the Academy of Finland projects 271832 and 24 273870 (E.-M.A.) and by the German Science Foundation (DFG, FOR 2092) (D.L.). 25 26 Present addresses: 3 Department of Biosciences, University of Milan, I-20133, Milano, Italy 27 28 Address correspondence to evaaro@utu.fi. 29 30 Plant Physiology Preview. Published on May 2, 2016, as DOI:10.1104/pp.16. 00200
A Content Analysis of Emotional and Rational Appeals in Selected Products Advertising

A content analysis of 200 television commercials was conducted in order to identify the frequency of emotional and rational appeals under important product categories. The study also investigated the most preferred appeals by rural and urban children of Punjab.480 respondents in the age group 8-14 years were selected for the study. Age and gender differences with respect to preferences in regard to appeals were also analyzed. The study indicated that all number of appeals present in food and beverages were large and the least were present in the case of toys and games. Emotional appeals like fun and happiness, jingles and slogans, humor was present in every commercial forming the base of appeals in commercials. The most typical appeals in commercials aimed at male children were action-adventure, sports, and play, whereas commercials aimed at female children emphasized nurturing, physical attractiveness, friendship, and romance. Having the best, competition, and achievement were the dominant appeals in commercials aimed at male teenagers, whereas romance, sexuality, and belonging to a group were emphasized in commercials aimed at female teenager.