Miracle-dz/UniFAR-FTUs huggingface dataset:
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide-induced apoptosis in human pulmonary vascular endothelial cells

ObjectiveReactive oxygen species initiate pulmonary vascular endothelial cell damage leading to an increase in endothelial permeability resulting in the production of pulmonary edema. Apoptosis signal-regulating kinase (ASK)-1 is a ubiquitously expressed mitogen-activated protein kinase kinase kinase (MAPKKK) that activates the MKK3/MKK6-p38 MAPK and the SEK1-c-Jun N-terminal kinase (JNK) signaling cascade. ASK1 has been implicated in cytokine- and stress-induced apoptosis. However, little is known about the role of ASK1 in apoptosis in hydrogen peroxide (H2O2)-stimulated pulmonary vascular endothelial cells and how ASK1-mediated apoptosis is executed. To clarify this issue, we examined the role of ASK1-p38 MAPK/JNK cascade in apoptosis and caspase-3 activation in H2O2-stimulated pulmonary vascular endothelial cells. DesignExperimental laboratory study. SettingUniversity laboratory. SubjectsNormal human pulmonary artery endothelial cells. InterventionsWestern blot analysis and quantification of apoptosis in cells. Measurements and Main ResultsThe results showed that H2O2 induced ASK1 phosphorylation and concomitantly p38 MAPK and JNK phosphorylation as well as induced caspase-3 activation in pulmonary vascular endothelial cells. To further characterize the role of ASK1 cascade in H2O2-induced apoptosis of pulmonary vascular endothelial cells, the dominant negative form of ASK1-stably transfected porcine artery endothelial cells was used. p38 MAPK and JNK phosphorylation, caspase-3 activation, and apoptosis in the dominant negative form of ASK1-stably transfected porcine artery endothelial cells were depressed compared with those in the parental porcine artery endothelial cells. ConclusionASK1-p38 MAPK/JNK cascade regulates apoptosis of H2O2-stimulated human pulmonary vascular endothelial cells.
Mortality in eating disorders

Synopsis Crude mortality rates and mortality rates standardized against a British reference population have been calculated for a group of 460 consecutive patients with eating disorders seen between 1971 and 1981 in a tertiary referral centre for eating disorders. Crude mortality rates were 3·3% and 3·1% in the anorexia nervosa and bulimia nervosa groups respectively. Standardized rates demonstrated a six-fold increase in mortality in the anorexia nervosa group. The most common cause of death in this group was found to be suicide, with the risk of death remaining high for at least eight years after initial assessment. Specific associations of increased mortality were: being in the lowest weight group at the time of presentation, and having recurrent hospital admissions for eating problems.
THE FINITE STRIP METHOD FOR ACOUSTIC AND VIBROACOUSTIC PROBLEMS

The finite strip method, widely employed in structural mechanics, is extended to solve acoustic and vibroacoustic problems. The acoustic part of the formulation, including how to handle the most typical acoustic boundary conditions and the fluid structure interaction, is presented. Several realistic problems where the three-dimensional domain of interest has extrusion symmetry are solved. These examples illustrate the advantages of the method: it has smaller computational costs than the finite element method and consequently the analyzed frequency range can be increased.
Categorization of regional and foreign accent in 5- to 7-year-old British children

This study examines children's ability to detect accent-related information in connected speech. British English children aged 5 and 7 years old were asked to discriminate between their home accent from an Irish accent or a French accent in a sentence categorization task. Using a preliminary accent rating task with adult listeners, it was first verified that the level of accentedness was similar across the two unfamiliar accents. Results showed that whereas the younger children group behaved just above chance level in this task, the 7-year-old group could reliably distinguish between these variations of their own language, but were significantly better at detecting the foreign accent than the regional accent. These results extend and replicate a previous study (Girard, Floccia, & Goslin, 2008) in which it was found that 5-year-old French children could detect a foreign accent better than a regional accent. The factors underlying the relative lack of awareness for a regional accent as opposed to a foreign accent in childhood are discussed, especially the amount of exposure, the learnability of both types of accents, and a possible difference in the amount of vowels versus consonants variability, for which acoustic measures of vowel formants and plosives voice onset time are provided.
Etude comparative de stratégies de sélection de prédicteurs pour l'attribution d'auteur

The authorship attribution problem can be viewed as a categorization problem. To determine the most effective features to discriminate between different writers (or categories), we have evaluated seven feature selection functions (e.g., pointwise mutual information, information gain, odds ratio, χ, or correlation coefficient). We have also considered two selection functions proposed in the context of authorship attribution. To compare these approaches, we have selected a newspaper corpus (Glasgow Herald) composed of 5,408 articles written by twenty columnists. Using the KLD (Zhao & Zobel, 2007) and the Delta (Burrows, 2002) attribution scheme, we found that some simple selection functions tend to produce results comparable to more complex ones. MOTS-CLÉS : Sélection de prédicteurs, attribution d'auteur, catégorisation de textes.
Saccharomyces cerevisiae mata mutant cells defective in pointed projection formation in response to α‐factor at high concentrations

We have isolated Saccharomyces cerevisiae MATa mutant cells that do not form a pointed projection but elongate in response to α‐factor at high concentrations. Complementation tests defined three genes, PPF1, PPF2, and PPF3 (for pointed projection formation), necessary for pointed projection formation. Allelism tests with genes known to be needed for projection formation revealed that PPF1 is identical to SPA2, while PPF2 and PPF3 are not allelic to SST2, STE2, SPA2, BEM1 or SLK1/SSP31/BCK1. The morphology of MATa ppf mutants treated with high concentrations of α‐factor is similar to that of MATa PPF cells treated with α‐factor at low concentrations. Quantitative mating tests showed that PPF2 and PPF3 are not essential for mating in either MATa or MATα background. Monitoring of division arrest and expression of an α‐factor‐inducible gene revealed that mutations in the PPF genes do not affect the responses of MATa cells to low concentrations of α‐factor. Unlike wild‐type cells, the ppf mutants exhibited early recovery from α‐factor‐induced division arrest. Furthermore, vegetatively growing ppf3‐1 cells are slightly defective in cell separation of mother and daughter cells and in selection of the correct bud sites in all cell types. These results indicate that PPF2 and PPF3 are involved in the response to α‐factor at high concentrations and that PPF3 is also required for proper establishment of polarity in vegetative growth.
A through wall UWB RADAR with mechanical sweeping system

This paper presents a UWB Radar system with mechanical scanning. The advantages of UWB technology for radar are exposed, followed by a description of the mechanical scanning system. Finally, we use image processing to detect a target through a wall. We measure the impact of the radiation pattern of two antennas to improve the cross-range resolution.
Forecasting in Financial Data Context

This paper aims to compare the application of most common forecasting techniques within financial data context such as regression analysis and artificial neural network, according to the most popular forecasting efficiency indices. Findings depicted that robust regression has an advantages over the least square regression and ANN, in financial data analysis because of outliers derived from business cycles. To this aim, relationship between earning per share, book value of equity per share and share price as price model and earnings per share, annual change of earning per share and return of stock as return model scrutinized implementing robust and least square regressions as well as ANN. Based on results, it can be concluded that the robust regression can provide better and more reliable analysis owing to eliminating or reducing the contribution of outliers and influential data. Therefore, robust regression outperforms OLS and ANN, and can be recommended reaching more precise analysis in financial data context.
Manic-Depressiveness, Obsessive-Compulsive Tendencies, and Suicidality in Kuwaiti College Students

In a sample of 87 Kuwaiti undergraduates (20 men, 67 women), obsessive-compulsive scores were associated with scores on measures of mania, depression, and suicidal thoughts. Multiple stepwise regression indicated that (a) obsession, suicidal attempts, and suicidal threats were predictors of depression, (b) depression, suicidal attempts, and obsession predicted suicidal thoughts, (c) age, doubting, and sex were predictors of suicidal threats, and (d) suicidal thoughts, depression, and obsession were predictors of suicidal attempts.
New Enzyme-Linked Chemiluminescent Immunosorbent Digoxin Assay Is Free From Interference of Chinese Medicine DanShen

Abstract: DanShen is a traditional Chinese medicine indicated for cardiovascular diseases. The potential interference of DanShen with serum digoxin measurement was investigated using a new enzyme-linked chemiluminescent immunosorbent (ECLIA) digoxin assay. Aliquots of drug-free serum were supplemented with ethyl acetate extract of DanShen (4 different brands studied), and apparent digoxin concentrations were measured by the ECLIA as well as fluorescence polarization immunoassay (FPIA) and a turbidimetric assay for comparison. Mice were also fed 4 DanShen preparations and apparent digoxin concentrations were subsequently measured. In another experiment, serum pools containing digoxin were further supplemented with DanShen extracts and digoxin concentrations were measured again by all 3 assays. No apparent digoxin concentration was observed when aliquots of drug-free serum pools were supplemented with DanShen and digoxin concentrations were measured by the ECLIA or the turbidimetric assay. In contrast, significant apparent digoxin concentrations were observed using FPIA, and the highest apparent digoxin concentration was observed with brand 4 of DanShen extract. Similarly, when mice were fed with this herb, significant apparent digoxin concentrations were also observed using FPIA, but neither ECLIA nor turbidimetric assay showed any apparent digoxin concentration. When aliquots of digoxin pool were further supplemented with various DanShen extract, the apparent digoxin concentrations were significantly increased when FPIA was used. In contrast, digoxin concentrations in the presence of DanShen extract compared well with the digoxin concentration of the original pool when ECLIA or turbidimetric assay was used. We conclude that DanShen does not interfere with serum digoxin measurement using a more recently released ECLIA digoxin assay.
From therapeutic community to self-sufficient community.

The authors believe that the concepts of therapeutic community and community psychiatry have been too narrowly understood and have been limited in application by various organizational strictures. They believe that through a greater understanding of social systems (through systems theory) natural communities such as the family and the larger social constellation can realize their potential as sources of help. The changes required to help systems such as institutional and community treatment programs become therapeutic include achieving consensus and commitment. To do so, a leader must replace traditional authoritarian leadership with a dynamic, coactive process of directing and moving with responsible people toward a common goal.
Dietary Energy Balance Modulates Prostate Cancer Progression in Hi-Myc Mice

Male Hi-Myc mice were placed on three dietary regimens [30% calorie restriction (CR), overweight control (modified AIN76A with 10 kcal% fat), and a diet-induced obesity regimen (DIO) 60 kcal% fat]. All diet groups had approximately similar incidence of hyperplasia and low-grade prostatic intraepithelial neoplasia in the ventral prostate at 3 and 6 months of age. However, 30% CR significantly reduced the incidence of in situ adenocarcinomas at 3 months compared with the DIO group and at 6 months compared with both the overweight control and DIO groups. Furthermore, the DIO regimen significantly increased the incidence of adenocarcinoma with aggressive stromal invasion, as compared with the overweight control group (96% vs. 65%, respectively; P = 0.02) at the 6-month time point. In addition, at both 3 and 6 months, only in situ carcinomas were observed in mice maintained on the 30% CR diet. Relative to overweight control, DIO increased whereas 30% CR reduced activation of Akt, mTORC1, STAT3, and NFκB (p65) in ventral prostate. DIO also significantly increased (and 30% CR decreased) numbers of T-lymphocytes and macrophages in the ventral prostate compared with overweight control. The mRNA levels for interleukin (IL) 1α, IL1β, IL6, IL7, IL23, IL27, NFκB1 (p50), TNFα, and VEGF family members were significantly increased in the ventral prostate of the DIO group compared with both the overweight control and 30% CR diet groups. Collectively, these findings suggest that enhanced growth factor (Akt/mTORC1 and STAT3) and inflammatory (NFκB and cytokines) signaling may play a role in dietary energy balance effects on prostate cancer progression in Hi-Myc mice. Cancer Prev Res; 4(12); 2002–14. ©2011 AACR.
Influence of left ventricular lead position relative to scar location on response to cardiac resynchronization therapy: a model study.

AIMS It is unclear how the position of the left ventricular (LV) lead relative to a scar affects the haemodynamic response in patients with dyssynchronous heart failure receiving cardiac resynchronization therapy. We investigated this complex interaction using a computational model. METHODS AND RESULTS The CircAdapt computational cardiovascular system model was used to simulate heart failure with left bundle branch block (LBBB). Myocardial scar was induced in four different regions of the LV free wall (LVFW). We then simulated biventricular pacing (BVP) in each heart, in which LV lead position was varied. The LV lead position leading to maximal acute change in LV stroke volume (SV) was defined as optimal lead position. In LBBB without scar, SV increase was maximal when pacing the LVFW region most distant from the septum. With a scar adjacent to the septum, maximal response was achieved when pacing remote from both the septum and the scar. When the scar was located further from the septum, the BVP-induced increase of SV was small. For all hearts, pacing from the optimal LV lead position resulted in the most homogeneous distribution of local ventricular myofibre work and the largest increase in summed left and right ventricular pump work. CONCLUSIONS These computer simulations suggest that, in hearts with LBBB and scar, the optimal LV lead position is a compromise between a position distant from the scar and from the septum. In infarcted hearts, the best haemodynamic effect is achieved when electromechanical resynchronization of the remaining viable myocardium is most effective.
Eye Gaze Calculation Based on Nonlinear Polynomial and Generalized Regression Neural Network

In this paper, we present a method of calculating the direction of the line of sight, which is based on nonlinear polynomial and generalized regression neural network, using a active infrared light source system. First of all, we get a model to map the gaze parameter to the gaze point under the circumstances of a static head with nonlinear polynomial and Generalized regression neural network are then used to compensate for different head position, so that nonlinear mapping function is extended to any head position, and then we can accurately estimate the gaze under head movement. The experiment and application in an interactive graphical interface system have verified the validity of this method.
A TEMPORAL MAP IN GEOSTATIONARY ORBIT: THE COVER ETCHING ON THE EchoStar XVI ARTIFACT

Geostationary satellites are unique among orbital spacecraft in that they experience no appreciable atmospheric drag. After concluding their respective missions, geostationary spacecraft remain in orbit virtually in perpetuity. As such, they represent some of human civilization's longest lasting artifacts. With this in mind, the EchoStar XVI satellite, to be launched in fall 2012, will play host to a time capsule intended as a message for the deep future. Inspired in part by the Pioneer Plaque and Voyager Golden Records, the EchoStar XVI Artifact is a pair of gold-plated aluminum jackets housing a small silicon disk containing 100 photographs. The Cover Etching, the subject of this paper, is etched onto one of the two jackets. It is a temporal map consisting of a star chart, pulsar timings, and other information describing the epoch from which EchoStar XVI came. The pulsar sample consists of 13 rapidly rotating objects, 5 of which are especially stable, having spin periods <10 ms and extremely small spin-down rates. In this paper, we discuss our approach to the time map etched onto the cover and the scientific data shown on it, and we speculate on the uses that future scientists may have for its data. The other portions of the EchoStar XVI Artifact will be discussed elsewhere.
Supplementation-time Dependence of Growth Factors in Promoting Tendon Healing

Growth factors potentially promote tendon healing. Understanding the right time to administer growth factors and the dosage of growth factors are prerequisites for designing effective cytokine therapy. We investigated the supplementation-time dependence of the effects of platelet-derived growth factor isoform B at various dosages on tendon healing, and the temporal responsiveness of healing tendon toward platelet-derived growth factor. Platelet-derived growth factor isoform B at various dosages (0, 10, 100, or 1000 ng) was delivered into the gap wound of rat patellar tendons via microsyringe injection on Day 3 or Day 7 after injury. Tendon specimens were harvested on Day 14 for measurement of cell proliferation, pyridinoline content, and mechanical properties. We found increased proliferative response only when the growth factor was supplemented on Day 3 after injury, whereas supplementation on Day 7 resulted in greater peak load, cross-sectional area, and pyridinoline content. The ultimate stress did not change. Our findings suggest supplementation of platelet-derived growth factor isoform B at Day 7 benefits the mechanical properties and maturation of healing tendons. We also found platelet-derived growth factor receptor β expressing cells at the remodeling site as much as 6 months after injury, suggesting healing tendon also may be responsive to long-term delivery of platelet-derived growth factor.
Diagnosis, Prophylaxis, and Treatment of Headaches in the Athlete

Background. Headaches are a common entity in the ambulatory population. Physicians involved in sports medicine must be able to accurately diagnose headaches in athletes and whether they are exacerbated by exertion. Many medications have proven or theoretical negative effects on athletic performance. Thus, we should consider all aspects of medical management and determine which therapy is least intrusive to the athlete's performance. We planned this review because of the small number of papers available on the effects of various medications on athletic performance. Methods. We used MEDLINE to search from 1992 to current citations, using the medical subject headings of headache, prophylaxis, treatment, review, athletes, and exercise, alone or in combination. Results. Fifty-two articles were identified and deemed appropriate for inclusion in this review. Conclusions. Acute therapy for tension headaches in the athletic population is best done with nonsteroidal anti-inflammatory drugs. Prophylaxis of chronic, recurrent tension headaches is best accomplished by night-time tricyclic antidepressants (especially nortriptyline) or selective serotonin reuptake inhibitors. Acute therapy for athletes with migraines is best managed with sumatriptan or DHE 45 and prophylaxis can be accomplished with verapamil, antidepressants, or valproate. Exertional, cluster, and structural/infectious headaches are also discussed briefly.
Managers and Students as Newsvendors

We compare how experienced procurement managers and students solve the newsvendor problem. We find that managers broadly exhibit the same kind of pull-to-center bias as students do. Also, managers use information and task training no better than students. The performance of managers is positively affected by the level of their education and their level in the organizational hierarchy. We discuss implications for theory and for how ordering might be improved in practice. This paper was accepted by Teck Ho, decision analysis.
STUDIES ON THE MECHANISMS OF ACTION OF VARIOUS PHTHALANILIDE DERIVATIVES BY CROSS-RESISTANCE AND TISSUE CULTURE.

In lines of leukemias P815 and P388 resistance has been developed to three Wander derivatives of different structures. Cross-resistance between the various members of this series has been studied. The lack of cross-resistance between certain of these derivatives suggests different mechanisms of action. In tissue culture with cells of leukemia P815Y there appears to be reasonably good correlation between in vivo and in vitro antileukemic activity. The Wander compounds so far studied are absorbed rapidly by the cells, but it takes 48–72 hours for the inhibitory effect to become evident. This technic would appear useful for screening and studying mechanisms of action of the Wander compounds.
An AC Josephson Voltage Standard up to the Kilohertz Range Tested in a Calibration Laboratory

This paper describes the development of an automated ac quantum voltmeter toward a turnkey system, which can be used for calibration of common dc and ac voltage standards. The setup was tested in an accredited commercial calibration laboratory to characterize Fluke 5700A calibrators and voltage standards. The measured voltage in dependence on various parameters is presented in the range of dc to 2 kHz with amplitudes up to 10 V. The uncertainty components are discussed, and the system relevant Type B uncertainty for ac voltage calibrations is 0.15 μV/V. The contribution of the leakage current is investigated in detail and found to be notable for frequencies above 1 kHz due to parasitic capacitances. The combined measurement uncertainty for calibration ac voltages is less than 0.62 μV/V (k = 1 and 40 Hz-1 kHz) and is limited by the noise of the calibrator. Comparison measurements at Physikalisch-Technische Bundesanstalt have been done and confirm the system reproducibility.
Noise radar concept and design for critical infrastructure surveillance in the SCOUT project

In the paper the system concept of critical infrastructure protection is presented. The described system is developed within the framework of FP7 European Union project on Multitech SeCurity system for intercOnnected space control groUnd staTions (SCOUT). The goal of the SCOUT project is to study, design and analyze a risk-based approach of a security system relying on multiple technologies. The noise radar is one of key sensor in the system, which is able to detect and track a wide spectrum of threats. The signal processing in the noise radar is described along with its applicability in the system.