Miracle-dz/UniFAR-FTUs huggingface dataset:
Generating unit tests with descriptive names or: would you name your children thing1 and thing2?

The name of a unit test helps developers to understand the purpose and scenario of the test, and test names support developers when navigating amongst sets of unit tests. When unit tests are generated automatically, however, they tend to be given non-descriptive names such as “test0”, which provide none of the benefits a descriptive name can give a test. The underlying challenge is that automatically generated tests typically do not represent real scenarios and have no clear purpose other than covering code, which makes naming them di cult. In this paper, we present an automated approach which generates descriptive names for automatically generated unit tests by summarizing API-level coverage goals. The tests are optimized to be short, descriptive of the test, have a clear relation to the covered code under test, and allow developers to uniquely distinguish tests in a test suite. An empirical evaluation with 47 participants shows that developers agree with the synthesized names, and the synthesized names are equally descriptive as manually written names. Study participants were even more accurate and faster at matching code and tests with synthesized names compared to manually derived names.
Wideband Circularly Polarized UHF Crossed Monopole Antenna With Unequal Power Feed for Handheld Terminals

A wideband circularly polarized crossed monopole antenna for handheld terminals operating at UHF band is presented. Two quasi-orthogonal monopoles loaded with meandering lines of unequal end-length are employed for compact low-profile design. A feeding network composed of an unequal power divider and <inline-formula><tex-math notation="LaTeX"> ${\text{90}}^{\circ}$</tex-math></inline-formula> phase shifter is meant for achieving wide operating band and circularly polarized radiation. Moreover, the ground for the feeding networks also serves as half ground for the radiating part. With proper arrangement of the size of meandering lines and feeding network accordingly, the proposed antenna was finally designed as compact as 0.24 <inline-formula><tex-math notation="LaTeX">$\lambda$</tex-math> </inline-formula> <inline-formula><tex-math notation="LaTeX">$\times$</tex-math></inline-formula> 0.20 <inline-formula><tex-math notation="LaTeX">$\lambda$</tex-math></inline-formula> <inline-formula> <tex-math notation="LaTeX">$\times$</tex-math></inline-formula> 0.005 <inline-formula><tex-math notation="LaTeX"> $\lambda$</tex-math></inline-formula>. Our measurements of a fabricated prototype confirm that the proposed antenna has an impedance bandwidth (<inline-formula><tex-math notation="LaTeX">$\boldsymbol {|S_{11}|}$</tex-math></inline-formula> < <inline-formula><tex-math notation="LaTeX">$-$</tex-math></inline-formula> 10 dB) of 30% and a 3 dB axial-ratio bandwidth of 17% around the center frequency 380 MHz, with stable radiation patterns and realized gain. Moreover, the antenna can be folded along the ground edge for potential space saving when it is unused.
Inhibitory effect of an antibody to cryptic collagen type IV epitopes on choroidal neovascularization.

PURPOSE The wet form of age-related macular degeneration (AMD) occurs as a consequence of abnormal blood vessel growth from the choroid into the retina. Pathological angiogenesis during tumor growth and ocular disease has been associated with specific exposure of cryptic extracellular matrix epitopes. We investigated the presence of cryptic collagen IV epitopes in a murine model of choroidal neovascularization (CNV), and tested the effect on blood vessel growth of H8, a humanized antibody directed against a cryptic collagen type IV epitope. METHODS To induce experimental CNV in adult C57BL/6 mice, Bruch's membrane was ruptured using a diode laser. Subsequently, mice were treated with daily intraperitoneal (i.p.) injections of either H8 (10 mg/kg or 30 mg/kg) or an isotype-matched antibody control. Two weeks postinjection, choroidal flat mounts were immunostained with the blood vessel marker platelet/endothelial cell adhesion molecule-1 (PECAM-1) and H8. CNV was visualized using fluorescence microscopy and the CNV lesion area measured using Open Lab software. RESULTS Collagen type IV and the cryptic epitope were observed at the site of laser-induced lesions. Staining with H8 was first observed three days post injury, two days after MMP2 expression in CNV lesions, becoming most intense five days following laser injury and extending beyond the area of neovascularization. At 14 days post injury, H8 staining was reduced in intensity, colocalized with the area of CNV, and was nearly absent from the underlying choroidal vessels. In addition, mice treated with H8 had a significant dose-dependent decrease in the area of CNV as compared to isotype-matched antibody controls. CONCLUSIONS Results suggest that exposure of cryptic collagen type IV epitopes is associated with the incidence of CNV and that the humanized antibody H8 may provide a new treatment for CNV.
Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations

Rationale: Reducing asthma exacerbation frequency is an important criterion for approval of asthma therapies, but the clinical features of exacerbation‐prone asthma (EPA) remain incompletely defined. Objectives: To describe the clinical, physiologic, inflammatory, and comorbidity factors associated with EPA. Methods: Baseline data from the NHLBI Severe Asthma Research Program (SARP)‐3 were analyzed. An exacerbation was defined as a burst of systemic corticosteroids lasting 3 days or more. Patients were classified by their number of exacerbations in the past year: none, few (one to two), or exacerbation prone (≥3). Replication of a multivariable model was performed with data from the SARP‐1 + 2 cohort. Measurements and Main Results: Of 709 subjects in the SARP‐3 cohort, 294 (41%) had no exacerbations and 173 (24%) were exacerbation prone in the prior year. Several factors normally associated with severity (asthma duration, age, sex, race, and socioeconomic status) did not associate with exacerbation frequency in SARP‐3; bronchodilator responsiveness also discriminated exacerbation proneness from asthma severity. In the SARP‐3 multivariable model, blood eosinophils, body mass index, and bronchodilator responsiveness were positively associated with exacerbation frequency (rate ratios [95% confidence interval], 1.6 [1.2‐2.1] for every log unit of eosinophils, 1.3 [1.1‐1.4] for every 10 body mass index units, and 1.2 [1.1‐1.4] for every 10% increase in bronchodilatory responsiveness). Chronic sinusitis and gastroesophageal reflux were also associated with exacerbation frequency (1.7 [1.4‐2.1] and 1.6 [1.3‐2.0]), even after adjustment for multiple factors. These effects were replicated in the SARP‐1 + 2 multivariable model. Conclusions: EPA may be a distinct susceptibility phenotype with implications for the targeting of exacerbation prevention strategies. Clinical trial registered with www.clinicaltrials. gov (NCT 01760915).
Integrating the Daughter into Family Business Management

This paper presents guidelines for integrating daughters into family business management. Based upon the results of an empirical study of daughters working with their founder/fathers in 18 family-owned firms, this paper indicates that the daughter represents an often untapped resource within the family firm and may be particularly suited for working in collaboration with the father/founder to manage the family firm. Key aspects of the daughter's particular strengths in working with the father to manage the family firm are stressed, and steps for integrating the daughter into family firm management are proposed.
Asset Prices and Optimal Monetary Policy Rules

We construct a New Keynesian DSGE model that features financial frictions, investment frictions, long-run productivity risk and Epstein-Zin preferences. The model successfully reproduces key features of both asset prices and macroeconomic quantities such as consumption, investment, and output. Under this set up, we examine the implications of different monetary policy rules where the central bank responds to inflation, output and asset prices in the presence of productivity shocks, monetary policy shocks and financial shocks. This paper contributes to the current debate on how central bankers ought to respond to asset price volatility, in the context of an overall strategy for monetary policy.
Development of electromagnetic linear actuators for micro robots

For micro robotic applications, piezoelectric actuators are widely used, whereas electromagnetic actuators are not favored because of the complex structures and difficult fabrication. On the other hand, electromagnetic actuators have many merits that are suitable for robotic applications, such as relatively large displacement or stroke and no need of high voltage power supply. With the recent fast development of micro precision machining techniques, the fabrication of complex structures is no longer a problem. This paper presents our recent study of developing electromagnetic actuators for micro robotic applications, including a comparison between piezoelectric and electromagnetic actuators, design of two types of electromagnetic actuators, and fabrication and testing of a moving magnet tubular linear actuator.
Agonist-induced Localization of Gq-coupled Receptors and G Protein-gated Inwardly Rectifying K+ (GIRK) Channels to Caveolae Determines Receptor Specificity of Phosphatidylinositol 4,5-Bisphosphate Signaling*

G protein-gated inwardly rectifying K+ (GIRK) channels are parasympathetic effectors in cardiac myocytes that act as points of integration of signals from diverse pathways. Neurotransmitters and hormones acting on the Gq protein regulate GIRK channels by phosphatidylinositol 4,5-bisphosphate (PIP2) depletion. In previous studies, we found that endothelin-1, but not bradykinin, inhibited GIRK channels, even though both of them hydrolyze PIP2 in cardiac myocytes, showing receptor specificity. The present study assessed whether the spatial organization of the PIP2 signal into caveolar microdomains underlies the specificity of PIP2-mediated signaling. Using biochemical analysis, we examined the localization of GIRK and Gq protein-coupled receptors (GqPCRs) in mouse atrial myocytes. Agonist stimulation induced a transient co-localization of GIRK channels with endothelin receptors in the caveolae, excluding bradykinin receptors. Such redistribution was eliminated by caveolar disruption with methyl-β-cyclodextrin (MβCD). Patch clamp studies showed that the specific response of GIRK channels to GqPCR agonists was abolished by MβCD, indicating the functional significance of the caveolae-dependent spatial organization. To assess whether low PIP2 mobility is essential for PIP2-mediated signaling, we blocked the cytoskeletal restriction of PIP2 diffusion by latrunculin B. This abolished the GIRK channel regulation by GqPCRs without affecting their targeting to caveolae. These data suggest that without the hindered diffusion of PIP2 from microdomains, PIP2 loses its signaling efficacy. Taken together, these data suggest that specific targeting combined with restricted diffusion of PIP2 allows the PIP2 signal to be compartmentalized to the targets localized closely to the GqPCRs, enabling cells to discriminate between identical PIP2 signaling that is triggered by different receptors.
"Rendre la parole pour mieux soigner". Evaluation de la pratique des médecins généralistes sur l'utilisation d'interprète professionnel face à un patient non francophone ou utilisateur élémentaire de la langue française à Toulouse

La communication est un pivot dans la relation entre deux individus, elle est basee sur l'echange entre un emetteur et un recepteur qui sont deux humains complexes. Cette complexite se retrouvent dans la consultation medicale et peuvent etre une source de malentendus. D'autres obstacles existent, notamment lorsque le medecin et le patient n'ont pas de langue commune. Quelle est la pratique des medecins generalistes sur l'utilisation d'interprete professionnel? Pour repondre a ces objectifs, nous avons realise une etude quantitative observationnelle descriptive transversale declarative par telephone sur l'ensemble de la population de medecins generalistes installes a Toulouse et recevant des patients non francophones ou utilisateurs elementaires de la langue francaise. Nous avons retrouve 130 medecins sur les 275 medecins generalistes, ils recoivent des patients non francophones ou dit utilisateurs elementaires de la langue francaise. Seuls 9% des medecins ont deja eu recours a des interpretes professionnels et 74% a des interpretes informels. Les freins a l'utilisation d'interprete professionnel sont principalement la meconnaissance des structures proposant un service d'interpretariat professionnel, la complexite de sa mise en place et le cout. 75% l'utiliseraient s'il etait mis a leur disposition mais avec des reserves. 91% n'ont pas recu de formation. Les medecins generalistes a Toulouse n'ont pas recours aux interpretes professionnels ; ceci est lie aux difficultes d'acces et a la formation des medecins. Cette etude quantitative ouvre sur une etude pilote pour evaluer la faisabilite d'un dispositif d'acces a des interpretes professionnels pour les medecins generalistes a Toulouse.
Classification of Kinin Receptors

Abstract This minireview is divided into three parts: the first part refers to the characterization and classification of kinin receptors using agonists and antagonists in isolated tissues (classical pharmacology). Two kinin receptors have been considered on the basis of their distinct pharmacology, namely the B1 receptor of the rabbit aorta (rank order of potency of agonists: LysdesArg9BK > desArg9BK >= LysBK>BK; apparent affinities of antagonists Lys[Leu8]desArg9BK (pIC50 8.4 ) > [Leu8]desArg9BK (pIC50 7.4)>>>HOE 140, a B2 receptor antagonist, pIC50<5.0), and the B2 receptor of the rabbit jugular vein (potency of agonists: LysBK = BK>>> LysdesArg9BK = desArg9BK and HOE 140 (pIC50 9.0)>>>Lys[Leu8]desArg9BK, pIC50<5.0). The second part describes speciesrelated B1receptor subtypes, demonstrated by different pharmacological profiles of agonists and antagonists: human, rabbit and pig subtypes (LysdesArg9BK >> desArg9B K and Lys[Leu8]desArg9BK > [Leu8]desArg9BK) and dog, rat, mouse and hamster B1 receptors (desArg9BK = LysdesArg9BK and [Leu8]desArg9BK = Lys[Leu8]desArg9BK). Affinities of agonists and antagonists in some species (man, rabbit, pig) are significantly increased (at least 10-fold) by the presence of a Lys at their Nterminus. The last part describes species-related B2 receptor subtypes supported by results obtained with non-peptide receptor agonists (FR 190997) and antagonists (FR 173657). While BK acts as a full agonist in man, rabbit and pig, FR 190997 behaves as a full agonist on human, as partial agonist on rabbit, and as pure antagonist on pig B2 receptors. Various hypotheses are considered to interpret these findings.
Microwave-enhanced electrochemical cycling performance of the LiNi0.2Mn1.8O4 spinel cathode material at elevated temperature.

The well-established poor electrochemical cycling performance of the LiMn2O4 (LMO) spinel cathode material for lithium-ion batteries at elevated temperature stems from the instability of the Mn(3+) concentration. In this work, a microwave-assisted solid-state reaction has been used to dope LMO with a very low amount of nickel (i.e., LiNi0.2Mn1.8O4, herein abbreviated as LMNO) for lithium-ion batteries from Mn3O4 which is prepared from electrolytic manganese oxide (EMD, γ-MnO2). To establish the impact of microwave irradiation on the electrochemical cycling performance at an elevated temperature (60 °C), the Mn(3+) concentration in the pristine and microwave-treated LMNO samples was independently confirmed by XRD, XPS, (6)LiMAS-NMR and electrochemical studies including electrochemical impedance spectroscopy (EIS). The microwave-treated sample (LMNOmic) allowed for the clear exposure of the {111} facets of the spinel, optimized the Mn(3+) content, promoting structural and cycle stability at elevated temperature. At room temperature, both the pristine (LMNO) and microwave-treated (LMNOmic) samples gave comparable cycling performance (>96% capacity retention and ca. 100% coulombic efficiency after 100 consecutive cycling). However, at an elevated temperature (60 °C), the LMNOmic gave an improved cycling stability (>80% capacity retention and ca. 90% coulombic efficiency after 100 consecutive cycling) compared to the LMNO. For the first time, the impact of microwave irradiation on tuning the average manganese redox state of the spinel material to enhance the cycling performance of the LiNi0.2Mn1. 8O4 at elevated temperature and lithium-ion diffusion kinetics has been clearly demonstrated.
Methylprednisolone and Acute Spinal Cord Injury: An Update of the Randomized Evidence

Objectives. Randomized trials are widely recognized as providing the most reliable evidence for assessing efficacy and safety of therapeutic interventions. This evidence base is used to evaluate the current status of methylprednisolone (MPSS) in the early treatment of acute spinal cord injury. Methods. Medline, CINAHL, and other specified databases were searched for MeSH headings “methylprednisolone and acute spinal cord injury. ” The Cochrane Library and an existing systematic review on the topic were also searched. Results. Five randomized controlled trials were identified that evaluated high-dose MPSS for acute spinal cord injury. Three trials by the NASCIS group were of high methodologic quality, and a Japanese and French trial of moderate to low, methodologic quality. Meta-analysis of the final result of three trials comparing 24-hour high-dose MPSS with placebo or no therapy indicates an average unilateral 4.1 motor function score improvement (95% confidence interval 0.6–7.6, P = 0.02) in patients treated with MPSS. This neurologic recovery is likely to be correlated with improved functional recovery in some patients. The safety of this regimen of MPSS is evident from the spinal cord injury trials and a systematic review of 51 surgical trials of high-dose MPSS. Conclusion. High-dose MPSS given within 8 hours of acute spinal cord injury is a safe and modestly effective therapy that may result in important clinical recovery for some patients. Further trials are needed to identify superior pharmacologic therapies and to test drugs that may sequentially influence the postinjury cascade.
Unfavourable prognosis associated with K-ras gene mutation in pancreatic cancer surgical margins

Background: Despite intent to cure surgery with negative resection margins, locoregional recurrence is common in pancreatic cancer. Aims: To determine whether detection of K-ras gene mutation in the histologically negative surgical margins of pancreatic cancer reflects unrecognised disease. Patients: Seventy patients who underwent curative resection for pancreatic ductal adenocarcinoma were evaluated. Methods: All patients had surgical resection margins (pancreatic transection and retroperitoneal) that were histologically free of invasive cancer. DNA was extracted from these paraffin embedded surgical margins and assessed by quantitative real time polymerase chain reaction to detect the K-ras gene mutation at codon 12. Detection of K-ras mutation was correlated with standard clinicopathological factors. Results: K-ras mutation was detected in histologically negative surgical margins of 37 of 70 (53%) patients. A significant difference in overall survival was demonstrated between patients with margins that were K-ras mutation positive compared with negative (median 15 v 55 months, respectively; p = 0.0008). By univariate and multivariate analyses, detection of K-ras mutation in the margins was a significant prognostic factor for poor survival (hazard ratio (HR) 2.8 (95% confidence interval (CI) 1.5–5.3), p = 0.0009; and HR 2.8 (95% CI 1.4–5.5), p = 0.004, respectively). Conclusions: Detection of cells harbouring K-ras mutation in histologically negative surgical margins of pancreatic cancer may represent unrecognised disease and correlates with poor disease outcome. The study demonstrates that molecular-genetic evaluation of surgical resection margins can improve pathological staging and prognostic evaluation of patients with pancreatic ductal adenocarcinoma.
Analysis, design, and sensitivity study of substrate integrated waveguide circuits by using equivalent circuit models

The design of complex substrate integrated waveguide (SIW) circuits requires the use of sophisticated full-wave simulation tools. When the complexity of the circuit increases, the computational effort required for the analysis and especially for the optimization of complex SIW circuits becomes prohibitive. For this reason the use of equivalent circuit models is very beneficial. This paper presents the derivation of parametric and multimodal equivalent circuit models of SIW discontinuities, based on the boundary integral-resonant mode expansion (BI-RME) method. To proof the validity of the models, the use of these equivalent circuits for the modeling and design of some SIW circuits, as well as for fast sensitivity study, is presented.
Prevalence of gingival enlargement secondary to calcium channel blockers in patients with cardiovascular diseases

Aim: The purpose of the present study was to determine the prevalence and extent of gingival overgrowth in patients treated with calcium channel blockers for cardiovascular diseases. Background: Calcium channel blockers are widely used in the treatment of hypertension, vasoplastic angina, and cardiacarrythmias. Gingival overgrowth resulting from the use of calcium channel blockers is of primary concern to dentists. The purpose of the present study is to determine the prevalence and extent of gingival overgrowth in patients treated with calcium channel blockers for various cardiovascular diseases, to assess their periodontal status and to correlate the factors like age, sex, duration, dosage, type of drugs that result in gingival overgrowth. Materials and Methods: A cross-sectional study was done in cardiac patients treated with calcium channel blockers, visiting The Railway hospital, Perumbur, Chennai. Information regarding medical history, type, duration, dosage of medication were recorded and analyzed. The periodontal condition of the patients was assessed using the plaque index, gingival index, calculus index, papillary bleeding index, and extent of gingival overgrowth using appropriate indices. The data was later subjected to statistical analysis. Results: In this study, a total of 213 cardiac patients (145 males and 68 females) who met the inclusion and exclusion criteria were screened. The patients were between 19 and 69 years. Conclusions: From the results of the present study it can be concluded that gingival overgrowth does occur with calcium channel blockers. Elderly males appeared to be more susceptible to the development of drug-induced gingival overgrowth, which was independent of dosage, duration of drug administered but the presence of local factors seemed to aggravate the same.