Miracle-dz/UniFAR-FTUs huggingface dataset:
Rarely seen autoimmune polyglandular syndrome; Type 3B complicated with celiac disease

Otoimmun poliglanduler sendrom (OPS) farkli otoimmun hastaliklarin kombinasyonudur. Klinik kriterler baz alinarak OPS'nin dort ana tipi tariflenmistir.Tip 3 formu; Addison hastaligi olmadan, otoimmun tiroid hastaliklarindan birine Tip 1 diabetes mellitus (Tip 3A) veya kronik atrofik gastrit, pernisiyoz anemi, colyak hastaligi, otoimmun hepatit (Tip 3B), vitiligo,alopesi,myastenia graves (Tip 3C), kollajen hastaliklar, vaskulit (Tip 3D) gibi otoimmun hastaliklarin eslik ettigi sendromdur. Colyak hastaligi (CD), guclu bir genetik etkiye sahip immun aracili bir hastaliktir. Tip 1 diabetes mellitus (T1DM) ve OTH, insanlarin bu hastaliklardan etkilendigi ve Colyak hastaligi gelisimi icin yuksek risk tasiyan iyi tanimlanmis iki hastaliktir. Burada T1DM ve OTH tanilari ile beraber Colyak hastaligi ile komplike olmus 32 yasinda kadin bir hastayi yani OPS Tip 3B sendromunu sunmaktayiz.
Forming intermediate spatial resolution of microscopy images for continuous zooming on multi-resolution processing system

Digital zooming especially on microscopy image has attempted to improve their quality of measurement into a better assessment. However, since the field of view of high-resolution image are not wide despite of the fact that high-resolution image has more information detail and low-resolution image has their merits which is bring a big picture of the whole structure, we need to observe the sample in any scale. This problem was been solved by developing dual-view of high and low images resolution1 but in a single interpolated images. The goal of this research is utilize multi-resolution images to develop smooth zooming magnification of microscopy image. In order to achieve smooth zooming magnification on different condition of the images, scheme process will be needed. First, we took a several spatial images of the same sample based on the different objective lens, author was used 4 objective lens which are 10×, 20×, 50× and 150× magnification. In this synthesize phase, we interpolate lower resolution image for synthesize purpose with the next higher resolution image of the sample. Second, continue to looking for the feature point of both images with SIFT feature point method until we synthesize both images. Third, author treat this synthesized image with discrete fourier transform (DFT) with low-pass filter as the same size with numerical aperture (NA) that was input on the first phase. Then the fourth phase is looping this processes until intermediate images are generated enough to be blend with pyramid blend method. In this article we also try to make a system that can arbitrarily generate intermediate image with hierarchical system.
Non-antibiotic management for Clostridium difficile infection

Clostridium difficile infection (CDI) is a key cause of diarrheal illness due to outbreaks by the hypervirulent C. difficile NAP1/027 strain. The mainstay and time-honored antibiotic therapies for the management of CDI apart from killing C. difficile, also disturbs the standard healthy gut flora leading to dysbiosis. Mismanagement of antibiotics has led to a widespread increase in antibiotic resistance which has jeopardized the efficacy of antibiotics. This article has shed some light on the present-day vista of non-antibiotic approaches to combat CDI which include bacteriotherapy (fecal microbiota transplant, probiotics, non-toxigenic C. difficile spores), immunoglobulin therapy (monoclonal antibodies, polyclonal antibodies, bovine antibodies, whey protein concentrate, colostrum, C. difficile vaccine), photodynamic therapy and other miscellaneous therapies like the use of adsorbents, prebiotics and corticosteroids.
NightBalance Sleep Position Treatment Device Versus Auto-Adjusting Positive Airway Pressure for Treatment of Positional Obstructive Sleep Apnea.

STUDY OBJECTIVES Compare treatment efficacy and objective adherence between the NightBalance sleep position treatment (SPT) device and auto-adjusting positive airway pressure (APAP) in patients with exclusive positional obstructive sleep apnea (ePOSA) defined as a supine apnea-hypopnea index (sAHI) ≥ 2 times the nonsupine AHI (nsAHI) and a nsAHI < 10 events/h. METHODS This prospective multicenter randomized crossover trial enrolled treatment naive participants with ePOSA (AHI ≥ 15 events/h and nsAHI < 10 events/h) or (AHI > 10 and < 15 events/h with daytime sleepiness and nsAH < 5 events/h). Polysomnography and objective adherence determination (device data) were performed at the end of each 6-week treatment. Patient device preference was determined at the end of the study. RESULTS A total of 117 participants were randomized (58 SPT first, 59 APAP first). Of these, 112 started treatment with the second device (adherence cohort) and 110 completed the study (AHI cohort). The AHI on SPT was higher (mean ± standard deviation, 7.29 ± 6.8 versus 3.71 ± 5.1 events/h, P < .001). The mean AHI difference (SPT-APAP) was 3.58 events/h with a one sided 95% confidence interval upper bound of 4.96 events/h (< the prestudy noninferiority margin of 5 events/h). The average nightly adherence (all nights) was greater on SPT (345.3 ± 111.22 versus 286.98 ± 128.9 minutes, P < .0001). Participants found the SPT to be more comfortable and easier to use and 53% reported a preference for SPT assuming both devices were equally effective. CONCLUSIONS Treatment with SPT resulted in non-inferior treatment efficacy and greater adherence compared to APAP in ePOSA suggesting that SPT is an effective treatment for this group. CLINICAL TRIAL REGISTRATION Registry: ClinicalTrials.gov; Title: The POSAtive Study: Study for the Treatment of Positional Obstructive Sleep Apnea; Identifier: NCT03061071; URL: https://clinicaltrials.gov/ct2/show/NCT03061071.
Advanced Glycation End Products (AGEs), Receptor for AGEs, Diabetes, and Bone: Review of the Literature

Abstract Diabetes compromises bone cell metabolism and function, resulting in increased risk of fragility fracture. Advanced glycation end products (AGEs) interact with the receptor for AGEs (RAGE) and can make a meaningful contribution to bone cell metabolism and/or alter function. Searches in PubMed using the key words “advanced glycation end-product,” “RAGE,” “sRAGE,” “bone,” and “diabetes” were made to explain some of the clinical outcomes of diabetes in bone metabolism through the AGE–RAGE signaling pathway. All published clinical studies were included in tables. The AGE–RAGE signaling pathway participates in diabetic complications, including diabetic osteopathy. Some clinical results in diabetic patients, such as reduced bone density, suppressed bone turnover markers, and bone quality impairment, could be potentially due to AGE–RAGE signaling consequences. However, the AGE–RAGE signaling pathway has some helpful roles in the bone, including an increase in osteogenic function. Soluble RAGE (sRAGE), as a ligand decoy, may increase in either conditions of RAGE production or destruction, and then it cannot always reflect the AGE–RAGE signaling. Recombinant sRAGE can block the AGE–RAGE signaling pathway but is associated with some limitations, such as accessibility to AGEs, an increase in other RAGE ligands, and a long half-life (24 hours), which is associated with losing the beneficial effect of AGE/RAGE. As a result, sRAGE is not a helpful marker to assess activity of the RAGE signaling pathway. The recombinant sRAGE cannot be translated into clinical practice due to its limitations.
Robotic biotissue curriculum for teaching the robotic pancreatoduodenectomy

Minimally invasive surgery has revolutionized the face of surgical practice. Use of the robot in pancreas surgery is emerging as a feasible and effective technique. Its wide-spread implementation remains hindered by the significant learning curve. We describe how the biotissue curriculum at the University of Pittsburgh can decrease the learning curve and lead to systematic implementation of the technique. The Biotissue Curriculum is the second step of the proficiency-based robotic surgery curriculum at the University of Pittsburgh. It is comprised of suture drills and four biotissue drills: the running hepaticojejunostomy (RHJ), interrupted hepaticojejunostomy (IHJ), gastrojejunostomy (GJ) and pancreatojejunostomy (PJ). The purpose is the deliberate practice of the operative steps with frequent objective feedback for trainees toward a designated standard of proficiency. The role of the biotissue curriculum, in the context of the robotic curriculum, in mitigating the learning curve is also explored. The implementation of a training curricula that includes inanimate or biotissue practice is important for future surgical practice when adopting the robotic pancreatoduodenectomy (RPD) considering a low number of cases per trainee and the need for safe implementation of new techniques. Outcomes on robotic gastrointestinal and specifically pancreas surgery have shown feasibility and non-inferiority compared to the open approach. The biotissue curriculum in the context of the proficiency based robotic curriculum serves to help trainees achieve proficiency while mitigating the learning curve.
Antimicrobial susceptibility of bacteria isolated from children infected eyes in Benha University hospital

The aim of current study is to characterize bacteria isolated from eye infections and evaluate the effectiveness of some antimicrobials found in eye drops in the Egyptian Market. Clinical bacterial isolates were recovered from patients having conjunctivitis from Benha University Hospital and identified using standard microbiological techniques. Antimicrobial susceptibility of these isolates against various antimicrobials was tested by the disc diffusion method. A total of eighty one bacterial isolates were identified in this study, 30 Gram positive isolates and 51 Gram negative isolates. The major bacterial isolates were Pseudomonas aeruginosa (37%) and Staphylococcus spp. (37%). All the isolates were susceptible to fluroquinolones, and almost all of them were susceptible to aminoglycoside antibiotics. While 75 isolates were susceptible to tetracycline and 71 isolates were susceptible to chloramphenicol. High resistance rates were observed for both bacitracin (45.7%) and fusidic acid (60.4%). Seven isolates were multidrug resistant (MDR). This study demonstrated that isolates from infected eye were highly sensitive to fluroquinolones and aminoglycosides. This study recommends that antimicrobial susceptibility should be performed for bacteria isolated from patients’ eyes before antimicrobial therapy to avoid emergence of MDR isolates
Clinical and radiological outcome of distal femur fractures treated surgically with locking compression plate

The incidence of distal femur fractures has increased significantly during recent decades, and the incidence is highest in older women and in adolescent boys and men. The present study was undertaken to assess the functional and radiological outcome of internal fixation of fractures of distal end femur surgically managed by distal femoral locking compression plate. Also to evaluate the effectiveness and complications of distal end femur fractures treated with locking compression plate based on rate of union, time till union, rate of infection, varus and valgus mal-alignment and fixation failures. A prospective study consisted of n = 32 subjects with distal femur fractures admitted to the Department of Orthopaedics, Mahatma Gandhi Memorial Hospital, Warangal, was conducted in the Department of Orthopaedics, Kakatiya Medical College, Warangal, Telangana, India for a period of one year. The subject’s age ranged from 18 – 74 years. Of n = 32 subjects, 28 cases showed radiological union within 20 weeks and the average time for union was 16 weeks. Delayed union was found in 2 cases. 2 cases operated for supracondylar fracture non-union with implant failure had delayed union which took 13 months for union. Weight bearing without pain was achieved in n = 30 cases with mean time 12.2 weeks. 8 cases had limb length shortening: < 1 cm in 3 cases and 1 – 2 cm in 1 patient, more than 2 cm shortening was seen in 4 cases. Functional outcome was assessed at the end of 1 year in terms of regaining the lost knee function using NEER’s Scoring System. Out of n = 32 subjects, n = 30 (93.75%) had excellent to fair results with no major complications. The functional outcome was Excellent in n = 19 (59.38%) subjects, Good in n = 6 (18.75%), Fair in n = 5 (15.63%) and Poor in only 2 (6.25%) cases. Conclusion: The locking compression plate represents an evolutionary approach to the surgical management of distal femoral fractures, but it does not completely solve the age old problems of nonunion and mal-union. It is an economical and safe fixation system for the treatment of fracture of any part of the long bones. The rate of union as well as increased range of motion, improved healing rate, restoration of articular surface, better biomechanical stability, decreased complication rates, decreased incidence of re-operation, early rehabilitation makes it a good treatment option. Therefore, if preoperative planning and biomechanical principles are followed, LCP may provide excellent fixation in difficult situations offering good treatment option.
Uma abordagem Branch and Bound para RCPSP em um ambiente de computação colaborativa

Um projeto pode ser representado por uma rede de atividades formando um grafo de precedencia, direcionado e aciclico. Quando a quantidade de recursos existentes e limitada, o problema de determinacao do menor tempo de realizacao do projeto e conhecido como RCPSP (Resource Constrained Project Scheduling). A solucao otima para o problema RCPS e reconhecidamente NP-hard. Este artigo mostra um algoritmo distribuido para a solucao otima do problema RCPS usando uma abordagem branch and bound. Este algoritmo foi implementado e avaliado num ambiente de computacao colaborativa, do tipo peer to peer, com escalonamento adaptativo distribuido para balanceamento de carga nos nos computacionais. Os resultados sugerem a escalabilidade do algoritmo apenas com a adicao de nos computacionais.
Integrated Modalities Search Framework for Digital English Language Text Holy Qur’an and Tafsir

English text is commonly used online for English language and other languages as well. This is one of its attributes that makes its usage gains more popularity than others. English text version of Holy Qur’an and Tafsir can be readable by those who cannot read the Arabic version in the transliterated form. However, a non-Arab native recitation might be different from the Arab native. Nevertheless, both Arab and non-Arab require the knowledge of Tafsir for understanding Quran word-by-word and its applications. Due to the availability of transliterated English text version of Quran, it is possible to further utilize the Text processing aspect of generic online search engine architecture to further deliver the knowledge of Quran. This research uses qualitative explorative approaches to present a framework through which “meaning”, “teaching”, “civilization”, “scientific miracles” and “Aqidah and Ibadah” are integrated for any English transliterated term of Quran into English explanation source through the knowledge of Tafsir. As a result, online user’s query will extract desirable sequences of refined integration of Quran explanation inculcating knowledge composition of Holy Qur’an and Tafsir. Three short surahs of Holy Qur’an and Tafsir are used for the evaluation of the proposed framework. Text processing procedure is applied and a corpus of the English transliterated terms explanation by Tafsir of Holy Qur’an and Tafsir are generated. This framework is suitable for the design of search engine suitable for spreading the knowledge of Holy Qur’an and Tafsir.
Screening and identification of potential target genes in head and neck cancer using bioinformatics analysis

Head and neck cancer (HNC) is the sixth most common cancer worldwide. Recent studies on the pathogenesis of HNC have identified some biochemical associations of this disease, but the molecular mechanisms are not clear. To explore the genetic alterations in head and neck tumors, to identify new high-specificity and high-sensitivity tumor markers, and to investigate potentially effective therapeutic targets, in silico methods were used to study HNC. The GSE58911 microarray dataset was downloaded from the Gene Expression Omnibus online database to identify potential target genes in the carcinogenesis and progression of HNC. Differentially expressed genes (DEGs) were identified and functional enrichment analysis was performed. In addition, a protein-protein interaction network was also constructed, and gene analysis was undertaken using Search Tool for the Retrieval of Interacting Genes and Cytoscape. A total of 648 differentially expressed genes were identified. Kyoto Encyclopedia of Genes and Genomes pathway and Gene Ontology functional enrichment analysis of DEGs included muscle system process, extracellular matrix organization, actin binding, structural molecule activity, structural constituent of muscle, extracellular region part, ECM-receptor interaction, amoebiasis, focal adhesion, drug metabolism-cytochrome P450, and chemical carcinogenesis. There were 26 hub genes identified and biological process analysis revealed that these genes were mainly enriched in extracellular matrix organization, serine-type endopeptidase activity, extracellular matrix, and complement and coagulation cascades. Survival analysis revealed that interleukin (IL)-8 (C-X-C motif chemokine ligand 8), IL1B, and serpin family A member 1 may be involved in the carcinogenesis of HNC. In summary, the DEGs and hub genes identified in the present study may increase understanding of the molecular mechanisms of development of HNC and provide potential target genes for clinical diagnosis and targeted therapy.
Stochastic outlook of two non-identical unit parallel system with priority in repair

Abstract The crux of the study is to investigate a two non-identical unit parallel system where priority is given to first unit. The system consists of two non-identical units arranged in parallel configuration. System failure occurs when both the units stop Working. Weibull failure and repair time distributions of each unit are taken. Several measures of system effectiveness, such as reliability, MTSF, steady state availability, expected profit etc., useful to system managers are obtained by using regenerative point technique. Further, recognizing the fact that the life testing experiments are very time consuming, the parameters representing the reliability characteristics of the system/unit are assumed to be random variables. Both informative and non-informative prior are used for the Bayesian analysis. Therefore, a simulation study is also conducted for analysing the considered system model both in classical and Bayesian setups.
Self-control, social learning theory, social bonds and binge drinking: Results from a national sample

ABSTRACT Binge drinking is still an issue among adolescents. The current study applies the theories of low self-control, social learning theory, and social bond theory to adolescent binge drinking. The data for this study comes from the 2011 Monitoring the Future Survey form two that is a nationally representative sample. The study found support for low self-control and social bond theory (i.e., definitions). The researchers also provide appropriate policy implications.
Caracterización de las alteraciones del sistema inmune innato en la lesión medular crónica

1 Unidad de Bioquímica y Biología Molecular, Departamento de Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, España. 2 Laboratorio de Enfermedades del Sistema Inmune, Departamento de Medicina y Especialidades Médicas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, España.
A new tomographic based keypoint descriptor using heuristic genetic algorithm

Keypoint descriptor is a fundamental component in many computer vision applications. Considering both computational complexity and discriminative power, SURF descriptor among non-binary and BRISK among binary descriptors are the prominent techniques in the field. Although, these descriptors have shown remarkable performance, but they are still suffering weaknesses such as lack of robustness against image transformations and distortions, especially blur, JPEG compression and lightening variation. To address this matter, a new and robust keypoint descriptor is proposed in this research which is adapted from Tomographic-Image-Reconstruction technique. Convolution of associated image patch and predefined Gaussian smoothed sensitivity maps yield a matrix whose entities demonstrate the average intensity of the pixels at the convolved pixels in the image patch. The initial descriptor vector is built by calculating the absolute differences of all possible pairs of matrix. Then, the most discriminative features of this initial descriptor vector are detected by Heuristic Genetic Algorithm (GA). The Experimental result showed that proposed keypoint descriptor outperformed some existing techniques especially in blur, JPEG compression and illumination variation while it has reasonable performance in other image transformations.
A cognitively plausible model for anaphora resolution

Anaphora resolution a is complex problem as it deals with syntax, semantics and discourse. The subject is well studied in field of psycholinguistics, where multiple preferences were discovered, and in the field of computational linguistics, where many systems have been developed to perform anaphora resolution in documents. Nevertheless, the work done in the two fields remains disconnected. We investigate how we can bridge the gap by exploiting the options for making a cognitively plausible model for anaphora resolution. Such model can be beneficent for both fields as it can inspire computational linguistics with findings about how humans process anaphora, and help the psycholinguistic community developing large coverage, incremental models simulating the human processing of anaphora.
Avoiding Complications Associated With Anemia Following Total Joint Arthroplasty

As the number of total knee arthroplasty surgeries exponentially rise over the next decade, there will be a parallel rise in the complications observed. Patients who undergo total knee arthroplasties will be at an increased risk for postoperative anemia and allogenic blood transfusions (ABTs). The range of complications associated with perioperative anemia and ABTs include increased length of stay (LOS) in the hospital, increased surgical site infections/periprosthetic joint infections, and mortality. There are many perioperative blood conservation strategies that can be utilized to help optimize a patient, prevent excessive bleeding, and reduce the need for possible ABTs. Although there is extensive research on this topic, there is a lack of consensus on the best strategy to help prevent perioperative anemia and the complications associated with it. Surgeons should be able to recognize perioperative anemia and utilize the information in this section to prevent its unnecessary complications.
Geodesign in Pampulha cultural and heritage urban area: Visualization tools to orchestrate urban growth and dynamic transformations

This paper discusses the role of visualization in Geodesign methodology considering its applications in the case study of the region of Pampulha in Belo Horizonte, Minas Gerais, Brazil. In order to consider the opinion of the participants, their efforts were recorded in different steps of the process, at different stages of Geodesign iterations, and different possibilities of visualization were tested. The methodology of Geodesign was applied in different applications and with different tools. The goal was to determine whether different techniques and tools used in the process of Geodesign contributed to improved understanding of data and problem context, and to derive guidelines for improved Geodesign techniques and tools.