Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-stakeholder microgrids for resilience and sustainability

ABSTRACT The electricity grid is susceptible to numerous threats, especially severe weather events that have the potential to cause large-scale power outages. This has resulted in an increased emphasis on resilience against these events. Microgrids, small standalone power grids that have the ability to function independently from the greater electricity grid, have significant potential to improve response to environmental and anthropogenic crises. The vast majority of extant microgrids are generally small in scale, and operated under a conventional model of single operator, owner, and user. We argue that the ultimate potential of this approach will be in the development of multi-stakeholder microgrids which can combine a diversity of renewable and conventional power resources to respond to environmental hazards. The addition of stakeholders allows for increased diversification of generation sources, economies of scale, and other increased operational benefits and opportunities. However, there are significant challenges that arise with the additional layer of stakeholders in terms of governance, cost, and technical operations that can cause the multi-stakeholder model to be more difficult to implement. We develop the case for multi-stakeholder microgrids as a response to environmental hazards, and outline the challenges and questions facing the development of this form of microgrid.
Strained and unstrained Si nanowire FETs

Recent experimental results on Si nanowire MOSFETs are presented. The devices were fabricated in a top-down approach on unstrained and biaxial strained SOI substrates exhibiting good I-V characteristics with Ion/Ioff-ratios of 107 and off-currents as low as 10{−-su13}A. Subthreshold slopes of about 70mV/dec for SOI n- and p-FETs and 65mV/dec for strained SOI n-FETs were obtained. The on-current and transconductance of Si NW-FETs fabricated on strained SOI substrates are 2.5 and 2.1 times larger, respectively, due to the uniaxial tensile strain along the wires. Moreover, current transport on surfaces with different crystal orientation in NWs is employed to match on-currents of SOI n- and p-FETs.
Evaluation of IGF System Component Levels and Mitogenic Activity of Uremic Serum on Normal Human Osteoblasts

To test the hypothesis that impairment in bone formation in renal osteodystrophy in adults with chronic renal failure (CRF) might be mediated in part by alterations in circulating levels of the insulin-like growth factor (IGF) system components, we compared serum levels of IGF-I, IGF-II, IGF-binding protein (IGFBP)-3, IGFBP-4 and IGFBP-5 in adults with CRF (CRF patients with parathyroid hormone (PTH) < 100 pg/ml, PTH > 300 pg/ml and end-stage renal failure (ESRF) patients) versus age-matched controls. To evaluate the biological significance of alterations in circulating level of IGF system components, we compared the mitogenic activity of the sera on proliferation of normal human osteoblasts in vitro by using [3H]thymidine incorporation. We found severalfold increased serum levels of IGFBP-3 (2-fold), IGFBP-4 (5-fold) and slightly increased IGF-II levels in ESRF patients as well as a 2.6-fold increase in free IGF-I in CRF patients with PTH < 100 pg/ml. The mitogenic activity was found to be increased in serum of kidney failure patients compared to controls. This was most pronounced in CRF patients with PTH < 100 pg/ml showing also a significant increase in free IGF-I and the lowest levels of the IGF-inhibitory IGFBP-4. Our data support the hypothesis that alterations in serum levels of stimulating (i.e. free IGF-I) and inhibitory IGF system components (i.e. IGFBP-4) may influence osteoblastic cell proliferation in renal osteodystrophy.
Plants Utilize a Highly Conserved System for Repair of NADH and NADPH Hydrates1[W][OPEN]

The hydrates formed from NADH and NADPH by chemical or enzymatic damage are repaired in plants by highly conserved enzymes that are targeted to multiple compartments. NADH and NADPH undergo spontaneous and enzymatic reactions that produce R and S forms of NAD(P)H hydrates [NAD(P)HX], which are not electron donors and inhibit various dehydrogenases. In bacteria, yeast (Saccharomyces cerevisiae), and mammals, these hydrates are repaired by the tandem action of an ADP- or ATP-dependent dehydratase that converts (S)-NAD(P)HX to NAD(P)H and an epimerase that facilitates interconversion of the R and S forms. Plants have homologs of both enzymes, the epimerase homolog being fused to the vitamin B6 salvage enzyme pyridoxine 5′-phosphate oxidase. Recombinant maize (Zea mays) and Arabidopsis (Arabidopsis thaliana) NAD(P)HX dehydratases (GRMZM5G840928, At5g19150) were able to reconvert (S)-NAD(P)HX to NAD(P)H in an ATP-dependent manner. Recombinant maize and Arabidopsis epimerases (GRMZM2G061988, At5g49970) rapidly interconverted (R)- and (S)-NAD(P)HX, as did a truncated form of the Arabidopsis epimerase lacking the pyridoxine 5′-phosphate oxidase domain. All plant NAD(P)HX dehydratase and epimerase sequences examined had predicted organellar targeting peptides with a potential second start codon whose use would eliminate the targeting peptide. In vitro transcription/translation assays confirmed that both start sites were used. Dual import assays with purified pea (Pisum sativum) chloroplasts and mitochondria, and subcellular localization of GFP fusion constructs in tobacco (Nicotiana tabacum) suspension cells, indicated mitochondrial, plastidial, and cytosolic localization of the Arabidopsis epimerase and dehydratase. Ablation of the Arabidopsis dehydratase gene raised seedling levels of all NADHX forms by 20- to 40-fold, and levels of one NADPHX form by 10- to 30-fold. We conclude that plants have a canonical two-enzyme NAD(P)HX repair system that is directed to three subcellular compartments via the use of alternative translation start sites.
Social Media Marketing and Value Co-Creation: A System Dynamics Approach

Nowadays social media and brand communities provide virtual places where the consumers can publicize their opinions about products and services and play an active role as marketers, advertisers, value creators through electronic word-of-mouth. Since most of the times these dynamics flow out of business control, in order to pursue firms’ objectives, managers and marketers operating in many sectors look at the web social community with growing interest. The present chapter presents a system-wide analysis of the links and feedback mechanisms between the different aspects of value co-creation through social media marketing and brand communities. For the purpose, it is proposed a qualitative model built according to the principles of System Dynamics, a computer-aided methodology for policy analysis and design. Causal loop & stock-and-flows structures integrate the socioeconomic feedbacks between key variables, selected according to relevant literature, social media and brand communities observations, interview to consumer influencers.
Hybridization among the ancient mariners: characterization of marine turtle hybrids with molecular genetic assays.

Reports of hybridization between marine turtle species (family Cheloniidae) have been difficult to authenticate based solely on morphological evidence. Here we employ molecular genetic assays to document the sporadic, natural occurrence of viable interspecific hybrids between species representing four of the five genera of cheloniid sea turtles. Using multiple DNA markers from single-copy nuclear loci, eight suspected hybrids (based on morphology) were confirmed to be the products of matings involving the loggerhead turtle (Caretta caretta) x Kemp's ridley (Lepidochelys kempii) (N = 1 specimen), loggerhead turtle x hawksbill (Eretmochelys imbricata) (N = 2), loggerhead turtle x green turtle (Chelonia mydas) (N = 4), and green turtle x hawksbill (N = 1). Molecular markers from mitochondrial DNA permitted identification of the maternal parental species in each cross. The species involved in these hybridization events represent evolutionary lineages thought to have separated 10-75 million years ago (mya) and thus may be among the oldest vertebrate lineages capable of producing viable hybrids in nature. In some cases, human intervention with the life cycles of marine turtles (e.g., through habitat alteration, captive rearing, or attempts to establish new breeding sites) may have increased the opportunities for interspecific hybridization.
Dynamic resource allocation in adaptive wireless multiuser multicarrier systems

Modern wireless multiuser multicarrier systems (MU-MC) incorporate Dynamic Resource Allocation (DRA), Adaptive Modulation and Coding (AMC) and Power Control (PC) to exploit multiuser diversity and achieve higher system throughput. In the literature, only a few proposed algorithms deal with the contiguous DRA problem (contiguous collection of resources). This paper formulates this high complexity problem, provides suitable throughput estimation metrics and a simple yet efficient solution. The proposed algorithm allocates in each step a contiguous collection of resources to the pending user resulting in the highest estimated throughput. Simulation results show that in this way, considerably improved performance can be achieved in terms of overall system throughput and spectral efficiency, compared to more conventional approaches.
Acute Effects of Zatebradine on Cardiac Conduction and Repolarization

Zatebradine, a potent bradycardic agent, is believed to act selectively at the sinoatrial node. The selectivity of such a property relative to various electrophysiologic classes of action is not well defined. To characterize the electrophysiologic properties of zatebradine, the corrected sinus node recovery time, sinoatrial conduction time, conduction intervals, atrial effective refractory period and monophasic action potential duration in the ventricle were measured before and after incremental doses of zatebradine (0.1-1.5 mg/kg) in 15 anesthetized dogs. The electrophysiologic effects of zatebradine developed immediately after a single IV bolus dose, reaching steady-steady-state at 15 minutes with the maximum effect evident at 0.75 mg/kg. The IC50 was 0.23 mg/kg. There was no significant effect on the sinus node recovery time. The PR interval on the electrocardiogram was significantly increased when the dose was higher than 0.25 mg/kg. The duration of the P wave and the PA interval were not changed. Zatebridine greatly increased the AH (from 135 to 178 milliseconds) without changing the HH and HV intervals in His bundle recordings. The EC50 of this effect was 0.58 mg/kg. The QRS interval was not changed. The QTc was significantly increased from 0.43 to 0.56 s½ (P < 0.05). The action potential duration was significantly increased by high dose zatebradine (> 0.5 mg/kg), the EC50 for this effect was 0.76 mg/kg. The atrium effective refractory period was significantly increased (31%) with an EC50 0.69 mg/kg. These results indicate that zatebradine selectively inhibits sinus node automaticity at low doses. The inhibition of the AV nodal conduction and the lengthening of the refractory period and repolarization in the atria and the ventricles occur at higher dose.
The Redox Potential of the Plastoquinone Pool of the Cyanobacterium Synechocystis Species Strain PCC 6803 Is under Strict Homeostatic Control1[C][W]

The redox state of the plastoquinone pool of Synechocystis sp. strain PCC 6803 is regulated between narrow limits, in contrast to the more dynamic chlorophyll a fluorescence signal. A method is presented for rapid extraction of the total plastoquinone (PQ) pool from Synechocystis sp. strain PCC 6803 cells that preserves the in vivo plastoquinol (PQH2) to -PQ ratio. Cells were rapidly transferred into ice-cold organic solvent for instantaneous extraction of the cellular PQ plus PQH2 content. After high-performance liquid chromatography fractionation of the organic phase extract, the PQH2 content was quantitatively determined via its fluorescence emission at 330 nm. The in-cell PQH2-PQ ratio then followed from comparison of the PQH2 signal in samples as collected and in an identical sample after complete reduction with sodium borohydride. Prior to PQH2 extraction, cells from steady-state chemostat cultures were exposed to a wide range of physiological conditions, including high/low availability of inorganic carbon, and various actinic illumination conditions. Well-characterized electron-transfer inhibitors were used to generate a reduced or an oxidized PQ pool for reference. The in vivo redox state of the PQ pool was correlated with the results of pulse-amplitude modulation-based chlorophyll a fluorescence emission measurements, oxygen exchange rates, and 77 K fluorescence emission spectra. Our results show that the redox state of the PQ pool of Synechocystis sp. strain PCC 6803 is subject to strict homeostatic control (i.e. regulated between narrow limits), in contrast to the more dynamic chlorophyll a fluorescence signal.
Research on resolution of bistatic forward-looking SAR based on spatial wavenumber of the point target

In this paper, a novel method of spatial resolution analysis for low frequency (LF) ultra-wideband (UWB) bistatic forward-looking SAR (BFSAR) is presented, which is based on the wavenumber domain spectrum support of point target. First, the imaging geometry and signal model of the LF UWB BFSAR are established, and the wavenumber domain spectrum support of the point target is analyzed. Then, the analytical expression of the spatial resolution of LF UWB BFSAR is derived. Finally, the simulation experiment is carried out, and the results prove the correctness and validity of the proposed method of spatial resolution analysis.
Differences in the Effectiveness of Frontal Air Bags by Body Size Among Adults Involved in Motor Vehicle Crashes

Objective. There is concern that small stature occupants (particularly women) involved in motor vehicle crashes (MVCs) may be at risk of injury or death from frontal air bags, though evidence to substantiate this concern is lacking. We sought to assess how occupant body size (measured through height and weight) affects air bag effectiveness in mitigating the risk of serious injury, after adjusting for important crash factors. Methods. This was a retrospective cohort study using a national population-based cohort of adult front-seat occupants involved in MVCs as included in the National Automotive Sampling System Crashworthiness Data System database (NASS CDS) from 1995 to 2006. Drivers and front-seat passengers 15 years and older involved in MVCs involving passenger vehicles and light trucks were included in the analysis. The primary outcome was serious injury, defined as an Abbreviated Injury Scale (AIS) score ≥3 in any body region. Multivariable logistic regression models were used to test interaction terms (effect modification) between air bags, body size, and injury. The predicted probability of injury across body sizes was plotted to further illustrate potential differences. Results. Sixty-nine thousand three hundred eighty-seven adult front-seat occupants during the 12-year period were included in the analysis, of which 9333 (2.3%) were seriously injured. There was no evidence that height or weight modified air bag effectiveness among all crashes (p > .40). In primary frontal collisions, there was some evidence for effect modification by weight (p = .04) but not by height (p = .59). When assessed using air bag deployment, height was a strong effect modifier (p = .0078), but not weight (p = .43). Predicted probability figures confirmed that occupant height modifies the effect of air bag deployment, but there was no similar visual evidence for body weight. Conclusions. In this sample, we found no consistent evidence that body size modifies the overall effectiveness of frontal air bags. However, among crashes involving air bag deployment, the effect of deployment on injury differs by occupant height, with a relative increase in the odds of serious injury among smaller occupants. In such crashes, the probability of injury with (versus without) deployment began to increase with occupant heights less than 155 cm (5′), reaching a level of statistical difference below 138 cm (4′ 6″).
Dose and time dependent apoptotic response in a human melanoma cell line exposed to accelerated boron ions at four different LET

The aim was to investigate and compare the influence of linear energy transfer (LET), dose and time on the induction of apoptosis in a human melanoma cell line exposed to accelerated light boron (10B) ions and photons. Cells were exposed in vitro to doses up to 6 Gy accelerated boron ions (40, 80, 125 and 160 eV nm – 1) and up to 12 Gy photons (0.2 eV nm – 1). The induction of apoptosis was measured up to 9 days after irradiation using morphological characterization of apoptotic cells and bodies. In parallel, measurements of cell-cycle distribution, monitored by DNA flow cytometry, and cell survival based on the clonogenic cell survival assay, were performed. In addition, the induction and repair of DNA double-strand breaks (DSB), using pulsed-field gel electrophoresis (PFGE) were studied. Accelerated boron ions induced a significant increase in apoptosis as compared with photons at all time points studied. At 1 – 5 h the percentage of radiation-induced apoptotic cells increased with both dose and LET. At the later time points (24 – 216 h) the apoptotic response was more complex and did not increase in a strictly LET-dependent manner. The early premitotic apoptotic cells disappeared at 24 h following exposure to the highest LET (160 eV nm – 1). A postmitotic apoptotic response was seen after release of the dose-, time- and LET-dependent G2/M accumulations. The loss of clonogenic ability was dose- and LET-dependent and the fraction of unrejoined DSB increased with increasing LET. Despite the LET-dependent clonogenic cell killing, it was not possible to measure quantitatively a LET-dependent apoptotic response. This was due to the different time course of appearance and disappearance of apoptotic cells.
REPRODUCTION AND HYBRID LOAD IN ALL‐HYBRID POPULATIONS OF RANA ESCULENTA WATER FROGS IN DENMARK

Abstract All‐hybrid populations of the water frog, Rana esculenta, are exceptional in consisting of independently and to some extent sexually reproducing interspecific hybrids. In most of its range R. esculenta reproduces hemiclonally with one of the parental species, R. lessonae or R. ridibunda, but viable populations of diploid and triploid hybrids, in which no individuals of the parental species have been found, exist in the northern part of the range. We test the hypothesis that nonhybrids arise every year in these all‐hybrid populations, but die during larval development. Microsatellite markers were used to determine the genotypes of adults and abnormal and healthy offspring in three allhybrid populations of R. esculenta in Denmark. Of all eggs and larvae, 63% developed abnormally or died, with some being nonhybrid (genomes matching one of the parental species), many being aneuploid (with noninteger chromosome sets), a few being tetraploid, and many eggs possibly being unfertilized. The 37% surviving and apparently healthy froglets were all diploid or triploid hybrids. In all three populations, gametogenesis matched the pattern previously described for all‐hybrid R. esculenta populations in which most triploid adults have two R. lessonae genomes. This pattern was surprising for the one population in which triploid adults had two R. ridibunda genomes, because here it leads to a deficiency of gametes with an R. lessonae genome and should compromise the stability of this population. We conclude that faulty gametogenesis and mating between frogs with incompatible gametes induce a significant hybrid load in all‐hybrid populations of R. esculenta, and we discuss compensating advantages and potential evolutionary trajectories to reduce this hybrid load.
Plausible deductive reasoning plan for business mathematics learners

When the student is not able to solve a given problem, a plausible deductive reasoning process should be offered to him/her. Our final goal is a development of an e-Learning system which could help students not too much and not too little so that they can acquire as much deductive experience of independent work as possible. In the paper, we illustrate a solution plan graph which is a plausible deductive reasoning material with a concrete word problem. Our guiding principle for conducting the deduction is the thinking method of “working backwards” from the unknown. The paper also illustrates the details of the working backwards method.
Distinct lipopeptide production systems for WLIP (white line-inducing principle) in Pseudomonas fluorescens and Pseudomonas putida.

The interaction of WLIP (white line-inducing principle), a member of the viscosin group of Pseudomonas lipopeptides, with tolaasin, a lipopeptide mycotoxin secreted by Pseudomonas tolaasii, enables identification of the mushroom pathogen relying on formation of a lipopeptide coprecipitate between confronted colonies of an indicator strain (designated Pseudomonas 'reactans') and P. tolaasii. The WLIP non-ribosomal lipopeptide synthesis system of the mushroom isolate P. 'reactans' LMG 5329 (Wip) was identified and shown to be most similar to the Pseudomonas fluorescens SBW25 viscosin system (Visc), but remarkably different from the WLIP-generating Wlp system previously identified in the rice rhizosphere isolate Pseudomonas putida RW10S2. The Wlp machinery is composed of modules most similar to those recruited for biosynthesis of the non-viscosin-type lipopeptides putisolvin and entolysin by strains from the P. putida clade. In line with the pronounced synteny between the wip and visc flanking regions, strain LMG 5329 was identified as an authentic P. fluorescens closely related to strain SBW25. In both P. putida and P. fluorescens, WLIP production confers similar phenotypes of microbial antagonism and surface colonization. Genotypes other than wlp or wip were not identified among WLIP producers isolated from mushroom, maize rhizosphere or water.