Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling and implementation of a fully-digital integrated per-core voltage regulation system in a 28nm high performance 64-bit processor

This paper describes modeling and implementation of a fully digital integrated linear voltage regulation system implemented in a 28nm x86-64 core to reduce power gating entry or exit latency. Running on a 100 MHz clock, the controller samples voltage using a time-to-digital converter, and controls a set of PFETs organized in a ring topology around the CPU cores to drop voltage down to a specified target value. A simple analytical model is developed and validated through fast Matlab-Simulink simulation, enabling quick design turnaround and reducing schedule impact. The regulation system is designed to support input-output voltages in the range 1.3 V - 0.55 V. Digitally-controlled header resistance values range from 1.5 Ω to 2 mΩ. Stable processor behavior is observed down to 0.6 V, enabling fast pseudo-power gating entry and exit. In a high-performance x86-64 dual-core microprocessor chip, the controller enables an effective 6% frequency increase for lightly threaded applications by increasing the boost state residency.
Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats

Context: Metabolic syndrome (MetS) has become one of the major health burdens worldwide. To date, no single pharmacological agent has been developed to correct metabolic abnormalities associated with MetS. Use of indigenous medicinal plants as alternative medicines against MetS could be beneficial due to multiple therapeutic usage, easy availability, and relatively few side effects. Objective: To investigate the protective effect of Clerodendron glandulosum Coleb. (Verbenaceae) aqueous leaf extract (CgE) against experimentally induced MetS in rats. Methods: Changes in body weight, food and fluid intake, plasma glucose, insulin, fasting insulin resistance index (FIRI), plasma total lipid profile, free fatty acids (FFA), oral glucose tolerance test (OGTT), blood pressure and vascular reactivity have been investigated in various experimental groups. Results: Fructose+CgE groups recorded significant decrement (P <0.05) in plasma glucose, insulin, FIRI, total cholesterol, triglycerides, LDL, VLDL and FFA, whereas plasma HDL level was significantly increased (P <0.05) along with an efficient clearance of glucose during OGTT and lowered area under curve values. FRU+CgE groups also showed significantly decreased (P <0.05) mean arterial blood pressure along with decreased vasoconstriction and increased vasorelaxation in response to administration of various pharmacological agents. These results were comparable with metformin treated rats. Discussion: C. glandulosum leaf extract ameliorates experimentally induced MetS by improving dyslipidemia and insulin resistance. Conclusion: This study provides the first pharmacological evidence for the protective role of C. glandulosum leaves against experimentally induced MetS. Thus, therapeutic use of C. glandulosum in controlling MetS is indicated.
Biology of Intervertebral Disc Aging and Degeneration: Involvement of the Extracellular Matrix

Study Design. A review of current knowledge and opinions concerning the biologic changes that take place during development, maturation and degeneration of the intervertebral disc. Objective. To provide an overview of the changes that occur in structure and composition of the extracellular matrix of the intervertebral disc and to explain the origin of such changes and their functional consequences. Summary of Background Data. The structure of the intervertebral disc, and, in particular, the composition of its extracellular matrix, changes throughout life, ultimately resulting in tissue degeneration in the adult. Methods. A review of the published scientific literature. Results. In the young disc, the outer anulus fibrosus and inner nucleus pulposus have clear physical and molecular properties, although these differences become less distinct in the adult. The age changes are due to variations in both the abundance and structure of the macromolecules, particularly aggrecan, and the structural variations may be due to changes in both synthesis and degradation. It is not clear how many of the changes are by design to adapt to the altered environment of the growing spine. However, it is commonly thought that the degradative changes are detrimental to disc function, a property that is exacerbated by the inability of the mature avascular disc to remove and replace accumulated degradation products. The rate at which these detrimental changes occur may vary between individuals because of genetic, biomechanical, and nutritional differences. Such changes are thought to form the basis of tissue loss associated with disc degeneration. Conclusion. Changes in intervertebral disc structure throughout life ultimately result in tissue degeneration and the need for medical intervention. Current research is aimed at trying to restore the integrity of the degenerate disc matrix by biologic means, although at present it is not clear what the structure of the most appropriate repair tissue should be or how it can be achieved.
High Quantum Efficiency and Low Droop of 400-nm InGaN Near-Ultraviolet Light-Emitting Diodes Through Suppressed Leakage Current

High quantum efficiency and low efficiency droop of 400-nm InGaN near-ultraviolet (NUV) light-emitting diodes (LEDs) are achieved using Al<sub>0.05</sub>Ga<sub>0.95</sub>N quantum barriers and 3-nm thin Al<sub>0.3</sub>Ga<sub>0.7</sub>N insertion layer on last barrier before p-Al<sub>0.15</sub>Ga<sub>0.85</sub>N electron blocking layer. At 100 A/cm<sup>2</sup>, for the fabricated 0.1-mm<sup>2</sup>-size LEDs with special designed barriers, the external quantum efficiency increases from 23.8% to 40.7%, and the efficiency droop ratio decreases from 40.5% to as low as 10.3%, as compared with the conventional NUV LEDs. APSYS simulations reveal that a significant suppressed leakage current is the main reason for the performance enhancement.
2007 The Dynamics of Technological Learning in Industrialisation

9 Biographical Note 10 INTRODUCTION 11 ANALYTICAL FRAMEWORK 13 DYNAMICS OF TECHNOLOGICAL LEARNING: A CASE 17 Duplicative Imitation Stage 17 Creative Imitation Stage 20 Innovation Stage 23 IMPLICATIONS FOR OTHER DEVELOPING COUNTRIES 27 REFERENCES 31 THE UNU/INTECH DISCUSSION PAPER SERIES 33
Exploration of the CC-EMA attack towards efficient evaluation of EM information leakage

This paper discusses the efficiency of the CC-EMA (Clockwise Collision based ElectoroMagnetic Analysis) attack on hardware implementation of 128-bit AES (Advanced Encryption Standard) block cipher. The analysis efficiency of CC-EMA was first discussed on a white-box setting, i.e., using a known-key AES (Advanced Encryption Standard) hardware [10]. Then, more realistic attack scenario was applied for CC-EMA, where the secret key of AES hardware was unknown, i.e., black-box analysis, and the attack efficiency in the key recovery was briefly discussed in [11]. In this paper, we revisit the previous work for CC-EMA and explore the attack efficiency of CC-EMA furthermore in order to evaluate the information leakage from proximal EM measurements of IC (Integrated Circuit) devices. In order to evaluate the attack efficiency under various attack environments, we construct a simulation environment, where the intensity of EM radiation is parameterised assuming that it follows a normal distribution. As a result, we show that CC-EMA attack delivers equal or superior performance in the key recovery compared to the CEMA (Correlation EMA) attack and the key can be recovered by CC-EMA with less than 1100 EM measurements, in such case that the EM intensity for CC could be measured distinctly.
Synchronization and Partial Synchronization Experiments with Networks of Time-Delay Coupled Hindmarsh-Rose Neurons

We study experimentally synchronization and partial synchronization in networks of Hindmarsh–Rose model neurons that interact through linear time-delay couplings. Our experimental setup consists of electric circuit board realizations of the Hindmarsh–Rose model neuron and a coupling interface in which the interaction between the circuits is defined. With this experimental setup we test the predictive value of theoretical results about synchronization and partial synchronization in networks.
Heparin Therapy for Congenital Antithrombin III Deficiency in Pregnancy

A patient with congenital antithrombin III deficiency and a history of thromboembolic events prior to pregnancy was successfully treated with subcutaneous heparin alone throughout two pregnancies. Although adjuvant antithrombin III infusions may have a role in the treatment of this disorder, especially in the peripartum period, there is no evidence that this approach is superior to heparin therapy alone. We present this case as further evidence that heparin therapy alone appears to be a safe and effective treatment for pregnant patients with this rare but serious disorder.
Performance of the Abbott RealTime CT/NG for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae

ABSTRACT A multicenter clinical study was conducted to evaluate the performance characteristics of the Abbott RealTime CT/NG assay, a multiplex real-time PCR assay, for simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae. The specimens were collected from a total of 3,832 male and female subjects at 16 geographically diverse sites. Specimens included male and female urine samples, male urethral swabs, female endocervical swabs, and self-collected and clinician-collected vaginal swabs. Specimens were tested with the automated Abbott RealTime CT/NG assay, Aptima Combo 2 assay (Gen-Probe), ProbeTec ET CT/GC assay (Becton Dickinson), and culture for N. gonorrhoeae. The Aptima Combo 2 assay, the ProbeTec assay, and the N. gonorrhoeae culture were used as the reference assays. For each subject, a patient infected status (PIS) was determined based on the combined results from the reference assays. The overall prevalence in female subjects was 8.9% for C. trachomatis and 3.8% for N. gonorrhoeae. The overall male prevalence was 18.2% for C. trachomatis and 16.7% for N. gonorrhoeae. The overall sensitivity and specificity of the Abbott RealTime CT/NG assay were 92.4% and 99.2% for C. trachomatis and 96.9% and 99.7% for N. gonorrhoeae, respectively. In comparison, the sensitivity and specificity, respectively, for the Aptima Combo 2 assay were 94.5% and 99.0% for C. trachomatis and 96.1% and 99.5% for N. gonorrhoeae, and those for the ProbeTec ET assay were 90.3% and 99.5% for C. trachomatis and 92.0% and 97.3% for N. gonorrhoeae in this study. The Abbott RealTime CT/NG assay offers C. trachomatis and N. gonorrhoeae dual detection with high sensitivity and specificity. The automated assay provides a useful alternative nucleic acid amplification assay for clinical laboratories and clinicians.
Incorporating organizational innovation as a missing link in the examination of the EO-performance linkage

Drawing from resource-based view (RBV), this study generally aimed to investigate the relationship between entrepreneurial orientation (EO), organizational innovation, and organizational performance.It also examined the mediating effect of organizational innovation on the relationship between EO and organizational performance.To achieve these objectives, data were gathered from the owners/managers of manufacturing SMEs in the west coast of Peninsular Malaysia.Of 531 questionnaires distributed, only 331 (60.5%) were analyzed PLS-SEM.Significance levels of 0.05 and 0.01 were used as the critical level for decision making on the hypotheses.All hypotheses on the direct and indirect relationships between the EO and organizational performance of SMEs was supported.The finding strongly supported the RBV theory when the main effect of EO and mediating effects of organizational innovation displayed significant change in the relationship.
Interactions entre rythmes rapides et rythmes lents dans la représentation de l’information olfactive dans le réseau bulbaire

Une particularite de la modalite sensorielle olfactive est la nature complexe du stimulus chimique a representer. Les cellules sensorielles de la cavite nasale sont sensibles aux traits physico-chimiques des molecules et transmettent cette information vers le bulbe olfactif, premier relais central de cette modalite. L’organisation des voies de projection vers le bulbe entraine une spatialisation de l’activite dans cette structure, ce qui constitue un mode de representation de l’information mais qui n’est pas suffisant a lui seul. Le bulbe olfactif est egalement marque par des phenomenes dynamiques preponderants. Tout d’abord le rythme respiratoire, qui organise temporellement le niveau d’activation de l’appareil sensoriel, ensuite les oscillations des potentiels de champs locaux, et enfin les oscillations sous-liminaires des potentiels de membrane des cellules. Ces elements dynamiques pourraient etre le support de la formation d’assemblees de neurones, sous-populations de cellules synchronisees transitoirement et permettant la representation de l’information suivant un principe spatio-temporel. Les travaux presentes dans cette these sont bases sur l’enregistrement conjoint des activites unitaires des cellules du bulbe, des oscillations des potentiels de champs locaux et de la respiration en reponse a des stimulations olfactives. Nous montrons les relations existant entre les differents phenomenes dynamiques et comment ils permettent d’organiser l’activite des cellules pour aboutir a la formation d’assemblees de neurones fonctionnelles. Nous mettons particulierement en evidence le role central de la respiration dans le fonctionnement integre du bulbe olfactif.
Dementia and mortality in persons with Down's syndrome.

BACKGROUND Numerous studies have documented that persons with Down's syndrome (DS) are at an increased risk of Alzheimer's disease (AD). However, at present it is still not clear whether or not all persons with DS will develop dementia as they reach old age. METHODS We studied 506 people with DS, aged 45 years and above. A standardized assessment of cognitive, functional and physical status was repeated annually. If deterioration occurred, the patients were examined and the differential diagnosis of dementia was made according to the revised Dutch consensus protocol and according to the ICD-10 Symptom Checklist for Mental Disorders. We compared our findings with those reported in the literature. RESULTS The overall prevalence of dementia was 16.8%. Up to the age of 60, the prevalence of dementia doubled with each 5-year interval. Up to the age of 49, the prevalence is 8.9%, from 50 to 54, it is 17.7%, and from 55 to 59, it is 32.1%. In the age category of 60 and above, there is a small decrease in prevalence of dementia to 25.6%. The lack of increase after the age of 60 may be explained by the increased mortality among elderly demented DS patients (44.4%) in comparison with non-demented patients (10.7%) who we observed during a 3.3-year follow-up. There was no decrease in incidence of dementia in the age group of 60 and above. Our findings are very similar to those published in the literature. Patients with dementia were more frequently treated with antiepileptic, antipsychotic and antidepressant drugs. The history of depression was strongly associated with dementia. CONCLUSIONS Our study is one of the largest population-based studies to date. We found that despite the exponential increase in prevalence with age, the prevalence of dementia in the oldest persons with DS was not higher than 25.6%.
What Can Educators Do to Better Prepare Women for Leadership Positions in the Hospitality Industry? The Perspectives of Women Executives in Hong Kong

ABSTRACT This study aimed to identify areas of training that universities could include in their undergraduate programs to better equip female graduates to pursue their leadership aspirations. Hong Kong was the research setting. In-depth interviews were conducted with 24 female executives in the hospitality and tourism industry. The soft skills shown to best prepare women to assume managerial positions included social and professional communication, nonverbal communication, building confidence, and leadership. The research indicated the prominence of soft skills over hard skills in today’s workplace. It yielded the novel finding that nonverbal communication and building confidence are important competencies for female graduates seeking leadership positions.
Polytetrafluoroethylene and bovine mesenterial vein grafts for hemodialysis access: a comparative study.

PURPOSE This study aimed to evaluate the safety and patency rate of bovine mesenterial vein grafts (BMVG) for vascular access (VA) in hemodialysis patients (HDP), compared to expanded polytetrafluorethylene (ePTFE grafts) over a mid- to long-term period. METHODS Patency and complication rate of 23 consecutive HDP with BMVG for VA were compared to a control group consisting of 23 similar HDP with ePTFE grafts. In both groups, the graft was placed preferably in a forearm loop configuration. The same surgeon performed all procedures. All patients were followed over a period of 4 yrs. RESULTS Graft placement was successful in all patients. Patency rates did not differ significantly in both groups. However, there were less severe complications in the BMVG group. CONCLUSION The BMVG is a viable alternative for HD access in patients where autologous construction is not possible, and should be given priority in patients with a failed ePTFE graft or high risk for infection.
Assessment of the Level of Disease State Knowledge among Hypertensive Patients in Public Sector Tertiary Care Hospitals of Quetta, Pakistan.

: Hypertension (HTN) is major health concern worldwide. More than 50% of deaths worldwide due to Hypertension as stated by WHO. Hypertension may lead to primarily cardiovascular diseases, cancers, chronic respiratory diseases and diabetes. Cardiovascular diseases (CVDs) are the main causes of mortality in persons with hypertension. This study aims to assess the disease state knowledge of Hypertension in hypertensive patients of two tertiary public sector hospitals of Quetta city Pakistan. The cross-sectional has been conducted in two public sector tertiary care hospitals with 273 sample size towards Hypertension was assessed by using pre-validated questionnaire which was approved by the research committee of faculty of Pharmacy. All analyses were performed by using SPSS 22.The result showed that maximum respondents 80.6% have adequate knowledge regarding hypertension. Mean comparison result showed that there is statistically significant difference among Locality (p <0.001), Ethnicity (p <0.001), Level of Education (p 0.002), Occupation (p 0.004) and Income (p 0.002) which shows statistically significant difference in the knowledge score. The results of study showed that Hypertensive patients have adequate knowledge about their disease and the prime source of reliable information is taken from health care providers and family and friends’. The findings showed that most of patients are aware towards the disease knowledge and its management to overcome further hypertensive problem or risk of other diseases.
Efficient separation and analysis of peroxisomal membrane proteins using free‐flow isoelectric focusing

We have elaborated a protocol for the fractionation of both hydrophilic and hydrophobic proteins using as a model the matrix and membrane compartments of highly purified rat liver peroxisomes because of their distinct proteomes and characteristic composition with a high quota of basic proteins. To keep highly hydrophobic proteins in solution, an urea/thiourea/detergent mixture, as used in traditional gel‐based isoelectric focusing (IEF), was added to the electrophoresis buffer. Electrophoresis was conducted in the ProTeam free‐flow electrophoresis (FFE) apparatus of TECAN separating proteins into 96 fractions on a pH 3–12 gradient. Consecutive sodium dodecyl sulfate‐polyacrylamide gel electrophoresis (SDS‐PAGE) analysis demonstrated that both matrix and the integral membrane proteins of peroxisomes could be successfully fractionated and then identified by mass spectrometry. This is documented by the detection of PMP22, which is the most hydrophobic and basic protein of the peroxisomal membrane with a pI > 10. The identification of 96 prominent spots corresponding to polypeptides with different physical and chemical properties, e.g., the most abundant integral membrane polypeptides of peroxisomes and specific ones of the mitochondrial and microsomal membrane, reflects the fractionation potential of free‐flow (FF)‐IEF, accentuating its value in proteomic research as an alternative perhaps superior to gel‐based IEF.
Grundlagen der elektrischen Energietechnik : Versorgung, Betriebsmittel, Netzbetrieb, Überspannungen und Isolation, Sicherheit

Aus den Besprechungen: . ". Im gesamten Buch wird die Arbeit mit Modellen, die die Anschauung fordern und die mathematische Behandlung erzwingen, bevorzugt. Zur Vorbereitung dient der 2. Abschnitt, mit den elektrischen Betriebsmitteln, Transformatoren und rotierenden Maschinen, Freileitungen sowie Mittel- und Hochspannungskabel. Sie werden an Modellen und Ersatzbildern erlautert und praxisnahe Bezuge, insbesondere auch aus okonomischer Sicht, vorgenommen. Das Buch schliesst mit einer geschickt ausgewahlten Zusammenstellung der wichtigsten Literatur und einem knappen Sachverzeichnis ab. Der Student lernt durch das Literaturverzeichnis auch wichtige Verbandspublikationen und Forschungsberichte sowie Tagungsbande kennen, die auf dem Sektor der Elektroenergieversorgung in seinem spateren Beruf eine Rolle spielen. Ohne jeden Zweifel ist dieses Hochschullehrbuch hinsichtlich Stoffauswahl, Systematik und Methodik, Darstellung, Prazision und Aussagen in Wort, Schrift, Gleichung und Zeichnung gelungen; es wird nicht nur fur Studenten, sondern auch fur den in der Praxis stehenden Ingenieur von Wert sein. Dies um so mehr, als jahrelange Erfahrungen in Industrie und Hochschule, die die beiden Autoren als Ingenieure und Hochschullehrer in ihrem Berufsleben sammeln konnten, im moglichen Umfang nachnutzungsbereit niedergelegt sind. " #"Energietechnik"#
Design of Compact Dual-Band Power Dividers With Frequency-Dependent Division Ratios Based on Multisection Coupled Line

In this paper, a design method of compact dual-band power dividers with frequency-dependant power division ratios in two separated bands is proposed. A multisection coupled-line scheme is presented that takes advantage of the different odd- and even-phase velocities of a microstrip implemented coupled line. The proposed method is applicable to an extended frequency ratio of 1.4-3 compared to the formerly investigated coupled-line dual-band transformer. The design procedures are demonstrated by two design examples, and measurements of the implemented circuits are made for verification.