Miracle-dz/UniFAR-FTUs huggingface dataset:
Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure.

Bioenergetic and hemodynamic consequences of cellular redox manipulations by 0.2-20 mM pyruvate were compared with those due to adrenergic stress (0.7-1.1 microM norepinephrine) using isolated working guinea-pig hearts under the conditions of normoxia, low-flow ischemia, and reperfusion. 5 mM glucose (+ 5 U/l insulin) + 5 mM lactate were the basal energy-yielding substrates. To stabilize left ventricular enddiastolic pressure, ventricular filling pressure was held at 12 cmH2O under all conditions; this preload control minimized Frank-Starling effects on ventricular inotropism. Global low-flow ischemia was induced by reducing aortic pressure to levels (20-10 cmH2O) below the coronary autoregulatory reserve. Reactants of the creatine kinase, including H+ and other key metabolites, were measured by enzymatic, HPLC, and polarographic techniques. In normoxic hearts, norepinephrine stimulations of inotropism, heart rate x pressure product, and oxygen consumption (MVO2) were associated with a fall in the cytosolic phosphorylation potential [( ATP]/[( ADP].[Pi]] as judged by the creatine kinase equilibrium. In contrast, infusion of excess pyruvate (5 mM) markedly increased [ATP]/[( ADP].[Pi]) and ventricular work output, while intracellular phosphate decreased; MVO2 remained constant under the same conditions. During reperfusion following ischemia, pyruvate effected striking and concentration-dependent increases in MVO2, phosphorylation potential, and inotropism. Pyruvate dehydrogenase flux was augmented during reperfusion hyperemia followed by near-complete recoveries of [ATP]/([ADP].[Pi]), contractile force, heart rate x pressure product, and MVO2 in the presence of 5-10 mM pyruvate. Pyruvate also attenuated ischemic adenylate degradation. Omission of glucose from the perfusion medium rendered pyruvate ineffective in postischemic hearts. Similarly, excess lactate (5-15 mM) or acetate (5 mM) failed to reenergize reperfused hearts and severe depressions of MVO2 and inotropism developed despite the presence of glucose. Apparently, subcellular redox manipulations by pyruvate dissociated stimulated mitochondrial respiration and increased inotropism from low cytosolic phosphorylation potentials. This was evidence against the extramitochondrial [ADP]. [Pi]/[ATP] ratio being the primary factor in the control of mitochondrial respiration. The mechanism of pyruvate enhancement of inotropism during normoxia and reperfusion is probably multifactorial. Thermodynamic effects on subcellular [NADH]/[NAD+] ratios are coupled with a rise in the cytosolic [ATP]/[( ADP].[Pi]) ratio at constant (normoxia) or increased (reperfusion) MVO2. (ABSTRACT TRUNCATED AT 400 WORDS)
An adaptive router architecture for heterogeneous 3D Networks-on-Chip

Three dimensional Network-on-Chip (3D NoC) is becoming increasingly popular to address the on-chip communication demands of modern multi-core systems. However, architectural framework of the 3D router uses more buffer resources than conventional 2D routers. Also, homogeneous 3D NoC topologies have more TSVs which have a costly and complex manufacturing process. To improve the performance and manufacturing cost in 3D NoCs we propose adaptive router architectures for heterogeneous and homogeneous 3D NoCs which combine both the area and performance benefits of static 2D and 3D router architectures. Experimental results show that with a negligible penalty of up to 0.4% in maximum operating frequency, we achieved performance improvement of up to 34% by replacing 2D static routers with adaptive routers in heterogeneous architectures.
Anomaly Detection with ANN and SVM for Telemedicine Networks

— In eveloped with rtificial Neural n intrusion kno AIDA among o achine learnin atabases. Therea etwork commun ehavior. The fir fferent real-wor nalyze the perf ulnerabilities are ere developed fferences on de pplying tradition nd support vecto
A printed monopole loaded with a non-Foster matching network in the VHF band; radiation considerations

Loading an electrically small antenna (ESA) with non-Foster active matching networks (MN) is an interesting way to obtain broad impedance bandwidth. Locating one of these active networks in the antenna structure itself can be advantageous especially when the application requires a compact design. The introduction of the so called sensitivity (Sens) parameter allows finding a suitable placement for the MN. Some radiation considerations can be described, according to the antenna plus MN topology chosen at a low sensitivity point.
Genetics, genomics and other molecular approaches: example of salt-sensitive hypertension.

S alt sensitivity has long been suspected to be involved in not only the development of arterial hypertension but also to trigger endothelial dysfunction [1] and alter vessel wall properties of large arteries without any effect on or beyond blood pressure elevation [2]. It is, therefore, comprehensible that UK/US/Canada/Europe and WHO recommendations were launched to generally reduce salt intake to less than 6 and 5 g/day, respectively. In the US, it is even recommended to reduce daily salt intake to less than 4 g in individuals above 40 years of age, Blacks, and those with hypertension. He et al. [3] were able to show that a modest reduction in salt intake caused significant decrease in blood pressure (and urinary albumin and pulse wave velocity, but perhaps blood pressureassociated) in different ethnic groups consisting of Whites, Blacks and Asians. It has been suggested that very-low-salt diets may have unintended adverse consequences [4], especially among patients with a more prominent counterregulatory response of the renin–angiotensin system. In an observational follow-up study of the Trials Of Hypertension Prevention, Cook et al. [5] showed that a 25–35% dietary salt reduction in individuals with prehypertension resulted in a 25–30% lower risk of cardiovascular outcomes in the long term (10–15 years post trial). With respect to more general health benefit approaches, using a coronary heart disease (CHD) policy model, salt intake reduction of about 3 g/day has been projected to substantially reduce the development of CHD, stroke, myocardial infarction and deaths from any cause in the US [6]. With these epidemiological studies in mind, possible interindividual differences in the clinical response to salt reduction
Functional antagonism between members of the myb family: B‐myb inhibits v‐myb‐induced gene activation.

The oncogene v‐myb and its cellular progenitor c‐myb encode nuclear, DNA binding phosphoproteins that control the expression of certain target genes in immature hematopoietic cells. Here, we report the isolation of a myb‐related chicken gene, chicken B‐myb. We show that expression of B‐myb, unlike that of c‐myb, is not restricted to hematopoietic cells, suggesting that B‐myb functions in a broader spectrum of cell types than c‐myb. We have identified the authentic chicken B‐myb protein as a nuclear protein of approximately 110 kDa. We show that the B‐myb protein specifically recognizes v‐myb binding sites in vitro and that binding is mediated by an N‐terminally located DNA binding domain. Although B‐myb protein recognizes myb binding sites, B‐myb fails to transactivate several myb‐responsive gene constructs as well as the endogenous myb‐responsive gene mim‐1. Instead, we find that B‐myb represses v‐myb‐ and c‐myb‐mediated activation of the mim‐1 gene, most likely by competing with other myb proteins for binding sites. Our results raise the possibility that B‐myb is an inhibitory member of the myb family.
Programming Cells to Work for Us

The past decade has witnessed the rise of an exciting new field of engineering: synthetic biology. Synthetic biology is the application of engineering principles to the fundamental components of biology with the aim of programming cells with novel functionalities for utilization in the health, environment, and energy industries. Since its beginnings in the early 2000s, control design principles have been used in synthetic biology to design dynamics, mitigate the effects of uncertainty, and aid modular and layered design. In this review, we provide a basic introduction to synthetic biology, its applications, and its foundations and then describe in more detail how control design approaches have permeated the field since its inception. We conclude with a discussion of pressing challenges in this field that will require new control theory, with the hope of attracting researchers in the control theory community to this exciting engineering area.
Family history of irritable bowel syndrome is the major determinant of persistent abdominal complaints in young adults with a history of pediatric recurrent abdominal pain.

AIM To assess the late outcome of teen-agers with a previous history of recurrent abdominal pain (RAP) or irritable bowel syndrome (IBS). METHODS A group of 67 children with RAP referred to the department from January 1986 to December 1995 was followed up between 5 and 13 years after the initial diagnosis by means of a structured telephone interview. We hypothesized that those patients with persistent adult IBS-like symptoms would be significantly more likely to report a family history of IBS in comparison with adults with no persistent abdominal complaint. RESULTS Out of the 52 trackable subjects, 15 were found to present IBS-like symptoms at follow-up (29%) whereas the majority (37 subjects) did not. Subjects with IBS-like symptoms were almost three times more likely to present at least one sibling with similar symptoms compared to subjects not complaining (40.0% vs 16.0%), respectively (P < 0.05 at Student t test). Subjects with IBS-like symptoms also reported a higher prevalence of extra-intestinal symptoms, such as back pain, fibromyalgia, headache, fatigue and sleep disturbances. CONCLUSION The study confirms previous observations indicating that pediatric RAP can predict later development of IBS. The latter appears to be greatly influenced by intrafamilial aggregation of symptoms, possibly through the learning of a specific illness behavior.
Relationships Between Cell-Free DNA and Serum Analytes in the First and Second Trimesters of Pregnancy

OBJECTIVE: To assess the relationship between first- and second-trimester cell-free DNA levels and maternal serum screening markers. METHODS: First- and second-trimester residual maternal serum samples from 50 women were obtained. First-trimester (pregnancy-associated plasma protein A and &bgr;-hCG) and second-trimester serum analytes (&bgr;-hCG, alpha-fetoprotein, unconjugated estriol, and inhibin A) had been measured at the time of sample receipt. All fetuses were male as confirmed by birth records. Cell-free DNA was extracted and measured by real-time quantitative polymerase chain reaction amplification using glyceraldehyde phosphate dehydrogenase and DYS1 as markers of total DNA and fetal DNA, respectively. Determination of linear associations between first- and second-trimester serum markers and cell-free DNA levels using Pearson correlations was performed. RESULTS: Statistically significant correlations between first-trimester pregnancy-associated plasma protein A multiples of the median and both total (r=0.36, P=.016) and fetal (r=0.41, P=.006) DNA in the first trimester were observed. There were no significant correlations between first-trimester serum human chorionic gonadotropin or any second-trimester serum marker with DNA levels. CONCLUSION: Correlation between serum pregnancy-associated plasma protein A and first-trimester circulating cell-free fetal and total DNA levels is a novel finding. Pregnancy-associated plasma protein A is a glycoprotein of placental origin, and its correlation to cell-free fetal DNA in maternal serum suggests a common tissue origin through apoptosis of placental cells. However, because pregnancy-associated plasma protein A and cell-free DNA were only marginally correlated and cell-free DNA can be reliably detected in the first trimester, the addition of cell-free DNA to serum screening strategies may be helpful in predicting adverse pregnancy outcome. LEVEL OF EVIDENCE: II
Functional neuroimaging of attention in the auditory modality

PREVIOUS functional neuroimaging studies of attention have emphasized the visual modality. We developed an auditory version of the continuous performance test (CPT) that included simple, focused and divided attention conditions. Positron emission tomographic (PET) scans were acquired during CPT performance in normal young adults and then submitted to statistical parametric mapping. Simple attention brought about a large region of activation involving the anterior cingulate gyrus and the right anterior/mesial frontal lobe. Focused and divided attention CPT conditions were compared but there were few significant differences. The findings are consistent with activation of an anterior attention network during auditory attention, without involvement of posterior attention structures which are more likely to vary in accordance with sensory modality.
Staphylococcal scalded skin syndrome due to burn wound infection.

UNLABELLED Introduction. The staphylococcal scalded skin syndrome is an acute exfoliation of the skin caused by exfoliative toxins A and B. Although Staphylococcus aureus is a common cause of burn wound infection, SSSS following burn wound infection is rare. Method. A retrospective review of all SSSS cases admitted to a regional burns service between January 2008 and January 2012 was undertaken. Results. Two cases of SSSS were reported during this time period as occurring following burns injury. The first case was a 17-month-old boy who had been hospitalized for a conservative treatment of 6% total body surface area (TBSA) mixed depth scald burns. On day four he developed exfoliation of 85% TBSA. The second case was a ten-month-old boy who sustained a 1% TBSA scald burn and was managed conservatively in the community by his general practitioner. On day five, he developed exfoliation of 80% TBSA. Staphylococcus aureus was isolated from the burn wounds in both cases. CONCLUSION These two cases show that it is vital for burns surgeons and intensive care specialists to be aware of the possibility of SSSS occurring in patients with burn injuries with its potential devastating effects.
Central and peripheral clocks in cardiovascular and metabolic function

The molecular circadian clock entrains biological rhythms to a 24‐hour schedule. Aspects of cardiovascular physiology and, indeed, the incidence of myocardial infarction and stroke are also subject to diurnal variation. The use of rodent models of disrupted clock function has begun to elucidate the role of the molecular clock in the pathophysiology of cardiovascular and metabolic disease. Yet taught by time, my heart has learned to glow for other's good and melt at other's woe. Homer.
The effects of perfluorination on carbohydrate-pi interactions: computational studies of the interaction of benzene and hexafluorobenzene with fucose and cyclodextrin.

The effect of benzene fluorination on C-H.pi interactions is studied using a number of computational methods applied to a range of intermolecular complexes. High level wavefunction methods (CCSD(T)) predict a slightly greater interaction energy for complexes of benzene with methane or fucose, compared to corresponding complexes involving hexafluorobenzene. A number of more approximate treatments, DFT with the M06-2X functional, PM3-D* and MM methods, give interaction energies within 1 kcal mol(-1) of the high level values, and also correctly predict that the interaction energy is slightly greater for benzene compared to hexafluorobenzene. However, the DFT-D model used here predicts that the interaction energy is slightly greater for hexafluorobenzene. Molecular dynamics simulations, employing the GLYCAM-06 force field, validated here, are used to model the complexes of benzene and hexafluorobenzene with beta-cyclodextrin in aqueous solution. We predict the binding free energies of the complexes to be within 0.5 kcal mol(-1), and suggest that the different chemical shifts of the H5 protons observed in the two complexes arise from their slightly different structures, rather than from different binding energies.
Study of magnetization switching for MRAM based memory technologies : a dissertation

This Dissertation is protected by copyright and/or related rights. It has been brought to you by ScholarWorks@UNO with permission from the rights-holder(s). You are free to use this Dissertation in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself.
Physical work capacity of firemen. With special reference to demands during fire fighting.

During work in hot environments with a self-contained compressed air line breathing apparatus (SCCALBA) firemen perform physically arduous work and are exposed to severe heat loading. In view of the overloading risk involved, firemen should receive regular medical checkups with exercise tests and electrocardiography (ECG). Four hundred and seventeen firemen from 20 to 59 a of age in the Stockholm Fire Service performed exercise tests, including ECG, at intensities of 100, 150 and 200 W. The calculated maximal aerobic power declined with increasing age. Forty-seven firemen (11 0/0) were unable to complete the exercise test. Thirty of these men were in the oldest age group (50-59 a), of which 34 % failed to complete the test. The test was usually stopped prematurely because of physical exhaustion, but ECG changes, high blood pressure, and joint pain were also common causes of interruptions in the oldest age group. On the basis of the above results and earlier measurements during simulated fire fighting in a SCCALBA, recommendations on the future examinations of the physical work capacity of firemen are discussed. Thus, a fireman should be capable of performing bicycle ergometer work for 6 min at an intensity of 200 W. In order to allow for the age-induced decline in physical work capacity, a prospective fireman should be able to perform exercise at 250 W in the preemployment examination. It is suggested that exercise tests with ECG recordings should be performed every fifth year up to the age of 40 and every other year thereafter. Moreover, no fireman over the age of 50 should be allowed to perform fire fighting in a SCCALBA. Efficient physical training at least twice a week should be a part of every fireman`s regular duties.
The usefulness of trauma scores in determining the life threatening condition of trauma victims for writing medical-legal reports

Objectives: In the Turkish legal system the severity of the victim’s injury determines the severity of the criminal penalty, and the life threatening condition stated in the medical-legal report is one of the main determinants for injury severity. The aim of this study is to investigate the effectiveness and usefulness of the trauma scores in determining the life threatening condition of trauma victims from the forensic aspect in order to write accurate medical-legal reports. Methods: Data of 296 forensic cases with blunt and penetrating trauma were obtained. The life threatening condition of patients stated in the medical-legal reports according to the criteria based on traditional forensic opinion were examined. For each case, Injury Severity Score (ISS), Revised Trauma Score (RTS), and Trauma and Injury Severity Score (TRISS) were calculated. The ROC curve analysis was used to investigate the success of the trauma scores in distinguishing patients with/without life threatening conditions. Logistic regression analysis was performed to measure the association between trauma scores and life threatening conditions. Results: The relations between all scores and groups (with and without life threatening risk) were found statistically significant. ISS was the most successful method in distinguishing traumatised patients both in a life threatening or non life threatening condition. Conclusions: Trauma scores can be used for making more objective, standardised, and accurate judgement on whether the injury was a life threatening one or not. These advantages of using trauma scores in such situations will also be helpful for the conclusion of the lawsuits shortly, but further studies are needed to confirm these findings.
Shape and structure for image matching and retrieval

We report on methods for using object shape and structure for matching a pair of images or an image and a drawing. These methods can be used in combination with the several methods using color and texture already in use in content based image retrieval (CBIR). Matching methods are based on edges, corners, and ribbons and the relations among them and can be controlled for rotation, translation, and scale invariance. Good results are shown on a small but diverse sample of images with man-made structure. Although we have been oriented toward CBIR because image parts are put into correspondence, the methods are also of general use in object tracking, recognition, registration, structural stereo, or perhaps even detection of shot boundaries in video.
L'enseignement du littéraire dans le secondaire algérien à l'ère du numérique

Leibniz voulait developper des boussoles du savoir ; il desirait generaliser les cartes et les repertoires de contenus. Il voulait faire l'inventaire du tresor public (le " thesaurus ") des savoirs disponibles, creer une immense memoire virtuelle de la culture et des arts. Tablant sur cette richesse, il voulait en profiter pour rearticuler les notions, pour construire des rangements en etoile, amenager des carrefours, multiplier les raccordements reticulaires, visualiser les relations entre les informations par des tableaux de correspondances. Il voulait que le transversal l'emporte sur le sectoriel, que les liens horizontaux ou diagonaux reunissent ce que l'on croyait disjoint. Immense reve panoptique, synoptique, combinatoire. Il voulait substituer a la multiplicite asservissante une representation plus compacte. Il pensait que la veritable science est source de simplification, et qu'elle s'abrege en s'augmentant. A l'ere des reseaux et du numerique, l'idee fondamentale de Leibniz parait plus actuelle que jamais. Son reve prend une actualite brulante, au moment ou se dessinent les " societes du savoir " et ou l'on s'interroge sur leur orientation, en particulier sur les necessaires reformes de l'education, vivier central, strategique de nos societes futures (Queau, 2010). L'introduction des technologies de l'information et de la communication dans le programme du secondaire algerien represente une restructuration globale de la pedagogie et des programmes qui est instituee afin d'ameliorer la qualite des apprentissages et de faire progresser la reorganisation de l'enseignement. L'ensemble de ces variables etant constamment interrogees a l'interieur d'une nouvelle vision de l'acte de formation dans lequel " l'approche par la competence " fonde la matrice de tout le systeme. C'est dans cette optique que nous envisageons d'analyser et de detailler l'ensemble des moyens proposes pour l'enseignement du texte litteraire face aux nouvelles fonctions du reseau numerique. Cette situation nous conduit a nous interroger sur l'apprentissage de ce type de texte ou l'implication de la production de sens et la saisie de la signifiance sont de mise. Quelle langue abordee, celle du numerique ou celle du litteraire ? L'enjeu est certainement de taille, surtout si le texte se prete a plusieurs lectures lorsqu'il est presente dans son contexte. Par texte, il nous faudra donc faire la distinction entre texte numerise et texte du livre papier. Notre article presente un corpus (compose dans des classes de lettres du secondaire) qui nous a permis d'analyser les pratiques pedagogiques, les enjeux didactiques et pedagogiques, ainsi que les activites orales et ecrites que peut presenter l'enseignement du texte litteraire lie aux technologies numeriques.