Miracle-dz/UniFAR-FTUs huggingface dataset:
An IEEE LOM Application Profile to Describe Serious Games «SG-LOM»

games have become an indispensable part of the training compared to traditional online training that is often seen as restrictive and boring sometimes by learners. However, despite the contribution and potential of serious games in the education, their integration in the learning process is limited, this is due to the lack of tools and features of tracking and assessment of the learner/Player. For this and after a study of existing standards for describing learning resources we find that they are incomplete when it comes to describe the serious games. This article explains how we can effectively deliver serious game for our students through LMS with a metadata schema to describe serious game as learning resources. This new metadata schema it is an application profile of IEEE LOM entitled "SG-LOM" which takes into account different evaluation studies and classifications of serious games. This metadata allows one hand to the serious games take advantage of features of tracking and assessments offered by these systems. On the other hand the LMS to complete their educational offer and reach a certain maturity.
A datacube approach to agro-geoinformatics

Agricultural maps produced from earth observation data are useful at several stages in the agricultural value chain and allow farmers to make rational and comprehensive decisions when planning, planting and growing new crops. Towards this direction, a platform for the online, real-time analysis of big earth observation data for precision agriculture applications has been designed and implemented. This platform currently provides services like vegetation detection, calculation of standard vegetation indices, canopy greenness estimation, land surface temperature estimation and time-series analytics. The service interface utilizes the OGC Web Coverage Processing Service (WCPS) standard which establishes analytics on spatio-temporal datacubes. Implementation of the service is based on the open-source scalable array engine, rasdaman.
First trimester prenatal diagnosis of trisomy 21 in discordant twins using fetal nuchal translucency thickness and maternal serum free b-hCG and PAPPA Screening for trisomy

Screening for trisomy 21 in twin pregnancies poses a serious clinical, ethical and moral dilemma (Reynolds, 1995), leading some authors to advocate that such screening should be discouraged (Wald et al., 1997). Nevertheless, algorithms have been developed (Wald et al., 1991; Spencer et al., 1994) for biochemical screening in twins during the second trimester which will allow detection of approximately 50% of cases when one twin is unaffected and the other affected (discordant twins). This theoretical model has been shown to work in routine screening practice (Verdin et al., 1997). Signi®cant interest is now focussed on moving screening for trisomy 21 into the ®rst trimester, when a combination of fetal nuchal translucency, maternal serum free b-hCG and PAPP-A have been shown to identify 90% of cases of trisomy 21 (Spencer et al., 1999) and 90% of other chromosomal anomalies (Tul et al., 1999; Spencer et al., 2000a, b, c). Sebire et al. (1996a) showed that fetal nuchal translucency could be used to screen both concordant and discordant twins for trisomy 21; and, more recently, data on the distribution of maternal serum biochemical markers has led to the development of a combined algorithm for screening twins in the ®rst trimester (Spencer, 2000). Here we present details of our ®rst case of twins in which trisomy 21 was prospectively detected and diagnosed.
Comparison of electromagnetic torque ripple in square wave and sine wave permanent magnet motor drives

This paper presents the comparison of torque ripple in a permanent magnet motor drive with trapezoidal and sine wave back EMFs, excited by quasi square and sinusoidal currents. The analysis is done for an application where the speed range requirement spans from 10 RPM to 500 RPM. The simulation results show that the permanent magnet motor drive with sinusoidal back EMF excited by a sinusoidal current, which is in phase with the back EMF, gives minimum torque ripple and maximum efficiency.
Insights into the Impact of Linker Flexibility and Fragment Ionization on the Design of CK2 Allosteric Inhibitors: Comparative Molecular Dynamics Simulation Studies

Protein kinase is a novel therapeutic target for human diseases. The off-target and side effects of ATP-competitive inhibitors preclude them from the clinically relevant drugs. The compounds targeting the druggable allosteric sites outside the highly conversed ATP binding pocket have been identified as promising alternatives to overcome current barriers of ATP-competitive inhibitors. By simultaneously interacting with the αD region (new allosteric site) and sub-ATP binding pocket, the attractive compound CAM4066 was named as allosteric inhibitor of CK2α. It has been demonstrated that the rigid linker and non-ionizable substituted fragment resulted in significant decreased inhibitory activities of compounds. The molecular dynamics simulations and energy analysis revealed that the appropriate coupling between the linker and pharmacophore fragments were essential for binding of CAM4066 with CK2α. The lower flexible linker of compound 21 lost the capability of coupling fragments A and B to αD region and positive area, respectively, whereas the methyl benzoate of fragment B induced the re-orientated Pre-CAM4066 with the inappropriate polar interactions. Most importantly, the match between the optimized linker and pharmacophore fragments is the challenging work of fragment-linking based drug design. These results provide rational clues to further structural modification and development of highly potent allosteric inhibitors of CK2.
Assessment of Surgical Operations for Ductal Carcinoma In Situ of the Breast

Abstract The choice of surgical procedure for the treatment of ductal carcinoma in situ (DCIS) remains clinically based. A meta-analysis was used to synthesize the results of 24 published clinical studies. Partial breast tissue excision appears to be as efficacious as mastectomy for the treatment of DCIS of the breast.
TIME SERIES ANALYSIS AND FORECASTING OF FOREST FIRE WEATHER

Forest fire is one of the most dangerous natural hazards around the world which meteorological factors are important for conducting forest fire. This objective is to compare the performances between Autoregressive Integrated Moving Average (ARIMA) and Holt-Winters (HW) models for the forecasting meteorological data including average wind speed, precipitation, temperature pressure and relative humidity in northern Thailand. As performance measures of models by using the minimum Mean Absolute Percentage Error (MAPE). The result showed that the HW model obtained better model with precipitation, pressure and relative humidity data. However ARIMA model appear to the better model with average wind speed and temperature data. Then we fit time series models to forecast meteorological factors year 2015.
Using Deep Web Technology in Scientific Data Sharing Platform

There's myriad of accessible information deposited in Deep Web, and the amount of the information is increasing rapidly. With the development of web application, there're more and more online databases, which make Deep Web a hot research topic. For the convenience of searching information in Scientific Data Sharing Platform, this paper does research of Deep Web application, and presents a system architecture of Deep Web data integration with details.
Artificial Vision for the Blind: Electrical Stimulation of Visual Cortex Offers Hope for a Functional Prosthesis

Electrical stimulation of the occipital cortex resulted in discrete photic sensations or "phosphenes" in two volunteers who had been totally blind for 7 and 28 years, respectively. Stimulation of multiple electrodes allowed one patient to recognize simple patterns, including letters. Both patients made an uneventful recovery, and the success of these experiments reinforces the hope that a functional visual prosthesis can be developed, although many problems remain to be solved.
Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass

Significance Change in the nervous system occurs in response to diverse inputs, both normal and pathological. Defining such changes is required for understanding normal nervous-system functions and pathologies—e.g., from learning and memory to intractable disease. A unique combination pharmacology strategy allows identification of distinct neuronal subclasses through their constant functional expression of a specific subset of signaling proteins. Phenotypic alterations in signaling for one specific neuronal subclass were tracked as a function of development. These alterations provide proof-of-principle that changes in individual types of neurons can be monitored as a function of learning, disease, or aging. Developing biomarkers and therapeutic interventions for intractable nervous-system pathologies will require simultaneously monitoring different neuronal subclasses for such changes early during disease progression. Change is intrinsic to nervous systems; change is required for learning and conditioning and occurs with disease progression, normal development, and aging. To better understand mammalian nervous systems and effectively treat nervous-system disorders, it is essential to track changes in relevant individual neurons. A critical challenge is to identify and characterize the specific cell types involved and the molecular-level changes that occur in each. Using an experimental strategy called constellation pharmacology, we demonstrate that we can define a specific somatosensory neuronal subclass, cold thermosensors, across different species and track changes in these neurons as a function of development. Cold thermosensors are uniformly responsive to menthol and innocuous cool temperature (17 °C), indicating that they express TRPM8 channels. A subset of cold thermosensors expressed α7 nicotinic acetylcholine receptors (nAChRs) but not other nAChR subtypes. Differences in temperature threshold of cold thermosensors correlated with functional expression of voltage-gated K channels Kv1.1/1.2: Relatively higher expression of KV1.1/1.2 channels resulted in a higher threshold response to cold temperature. Other signaling components varied during development and between species. In cold thermosensors of neonatal mice and rats, ATP receptors were functionally expressed, but the expression disappeared with development. This developmental change occurred earlier in low-threshold than high-threshold cold thermosensors. Most rat cold thermosensors expressed TRPA1 channels, whereas mouse cold thermosensors did not. The broad implications of this study are that it is now feasible to track changes in receptor and ion-channel expression in individual neuronal subclasses as a function of development, learning, disease, or aging.
[Change of serum soluble intercellular adhesion molecule and basic fibroblast growth factor in patients with acute cerebral infarction and its clinical significance].

OBJECTIVE To explore the changes of the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and basic fibroblast growth factor (bFGF) in serum of patients with acute cerebral infarction, and the effects of sICAM-1 and bFGF on cerebral infarction. METHODS ELISA was used to detect the serum sICAM-1 and bFGF of 55 patients with acute cerebral infarction (within 2 days) as well as 32 patients diagnosed as with other neurologic diseases (20 patients with sciatica and 12 with trigeminal neuralgia) and 30 healthy persons as controls. RESULTS (1) Both serum sICAM-1 and bFGF in the infarction group were significantly higher [(766.2 +/- 178.8) micro g/L and (17.4 +/- 8.2) micro g/L respectively] than in other disease control group [(529.6 +/- 76.7) micro g/L and (8.3 +/- 2.8) micro g/L respectively] and normal control group [(520.7 +/- 115.9) micro g/L and (5.8 +/- 2.7) micro g/L respectively] (P = 0.000). (2) Correlation analysis showed that there was a positive correlation between the level of serum sICAM-1 and bFGF (r = 0.471, P = 0.000), the level of sICAM-1 was also positively correlated with the number of leukocytes at acute stage (r = 0.285, P = 0.035), and a negative correlation between sICAM-1 and European stroke scale (r = -0.333, P = 0.013) was found. No significant correlation was observed between the level of sICAM-1 and the levels of serum cholesterol (r = -0.042, P = 0.758) or triglyceride (r = 0.061, P = 0.675). (3) Blood pressure seemed to have no influence on the content of sICAM-1 and bFGF after cerebral infarction, while the level of serum bFGF with large infarct size was obviously higher at acute stage. CONCLUSION The levels of sICAM-1 and bFGF increase significantly in the patients with acute cerebral infarction. sICAM-1 and bFGF mayin participate in the pathophysiologic process through inflammatory mechanism. The detection of serum sICAM-1 will be helpful in estimating the clinical severity and the determination of bFGF will be helpful in estimating the size of infarct lesion at acute stage of cerebral infarction.
A Cam Deformity Is Gradually Acquired During Skeletal Maturation in Adolescent and Young Male Soccer Players

Background: A cam deformity is a major risk factor for hip osteoarthritis, and its formation is thought to be influenced by high-impact sporting activities during growth. Purpose: To (1) prospectively study whether a cam deformity can evolve over time in adolescents and whether its formation only occurs during skeletal maturation and (2) examine whether clinical or radiographic features can predict the formation of a cam deformity. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: Preprofessional soccer players (N = 63; mean age, 14.43 years; range, 12-19 years) participated both at baseline and follow-up (mean follow-up, 2.4 ± 0.06 years). At both time points, standardized anteroposterior and frog-leg lateral radiographs were obtained. For each hip, the α angle was measured, and the anterosuperior head-neck junction was classified by a 3-point visual system as normal, flattened, or having a prominence. Differences between baseline and follow-up values for the α angle and the prevalence of each visual hip classification were calculated. Additionally, the amount of internal hip rotation, growth plate extension into the neck, and neck shaft angle were determined. Results: Overall, there was a significant increase in the prevalence of a cam deformity during follow-up. In boys aged 12 and 13 years at baseline, the prevalence of a flattened head-neck junction increased significantly during follow-up (13.6% to 50.0%; P = .002). In all hips with an open growth plate at baseline, the prevalence of a prominence increased from 2.1% to 17.7% (P = .002). After closure of the proximal femoral growth plate, there was no significant increase in the prevalence or increase in severity of a cam deformity. The α angle increased significantly from 59.4° at baseline to 61.3° at follow-up (P = .018). The amount of growth plate extension was significantly associated with the α angle and hip classification (P = .001). A small neck shaft angle and limited internal rotation were associated with cam deformities and could also significantly predict the formation of cam deformities (α angle >60°) at follow-up. Conclusion: In youth soccer players, cam deformities gradually develop during skeletal maturation and are probably stable from the time of growth plate closure. The formation of a cam deformity might be prevented by adjusting athletic activities during a small period of skeletal growth, which will have a major effect on the prevalence of hip osteoarthritis.
Control of retinoblastoma cell growth by differentiating agents: current work and future directions.

It has become clear over the last few years that malignant transformation for several tumors results from failure of embryonic tissue to properly differentiate and activation of a mechanism which triggers uncontrolled cellular proliferation. Retinoblastoma fits this pattern, in that early inactivation of regulatory genes leads to proliferation of cells that are arrested in a primitive stage of development. Cultured Y-79 human retinoblastoma cells, however, can be induced to differentiate to a more "normal" stage in development through the use of several naturally occurring agents, such as butyrate, cyclic AMP, and retinoic acid. These agents cause reversible growth inhibition (e.g., retinoic acid) or result in cell death (e.g., butyrate). Proteins translated from mRNAs isolated from Y-79 cells are dramatically altered by all the above substances. Thus, alteration in transcriptional activity and changes in macromolecular synthesis can lead to the transition of rapidly growing, non-differentiated retinoblastoma cells to a non-proliferating, more differentiated state. The changes of the mRNA species induced with the various agents we have utilized, supports the hypothesis that differentiation and growth inhibition in Y-79 cells are programmed genetic events which can be controlled at least in vitro. Screening and testing of differentiating agents could be clinically useful for the treatment of retinoblastoma as well as for better understanding the biological control mechanisms involved in tumor growth.
Factors Affecting Measurement of Salivary Cortisol and Secretory Immunoglobulin A in Field Studies of Athletes

Aims Biological and lifestyle factors, such as daily rhythm, caffeine ingestion, recent infection, and antibiotic intake, have been shown to influence measurements of salivary cortisol (SC) and secretory immunoglobulin A (sIgA). Current methodology in unsynchronized, field-based biomarker studies does not take these effects into account. Moreover, very little is known about the combined effects of biological and lifestyle factors on SC and sIgA. This study supports development of a protocol for measuring biomarkers from saliva collected in field studies by examining the individual and combined effects of these factors on SC and sIgA. Method At three time points (start of the pre-season; start of playing season; and end of playing season), saliva samples were collected from the entire squad of 45 male players of an elite Australian Football club (mean age 22.8 ± 3.5 years). At each time, point daily rhythm and lifestyle factors were determined via a questionnaire, and concentrations of both SC and sIgA via an enzyme linked immuno-sorbent (ELISA) assay of saliva samples. In addition, player times to produce 0.5 mL of saliva were recorded. Results Analysis of covariance of the data across the three time points showed that daily rhythm had a more consistent effect than the lifestyle factors of caffeine ingestion, recent infection, and antibiotic intake on SC, but not on sIgA. Data for sIgA and SC concentrations were then adjusted for the effects of daily rhythm and lifestyle factors, and correlational analysis of the pooled data was used to examine the relative effects of these two sources of influence on sIgA and SC. With the exception of time to produce saliva, the biological measures of stress were affected by players’ daily rhythms. When daily rhythm was taken into account the group of lifestyle factors did not have an additional effect. Discussion It is recommended that future studies measuring SC and sIgA make additional adjustments for the daily rhythm, in particular time since first sight of daylight, as small measurement errors of biomarkers can confound discrimination among study participants.
Effects of EMFs on some biological parameters in coffee plants (Coffea arabica L.) obtained by in vitro propagation

In vitro coffee seedlings were exposed to an electromagnetic field (EMF) of 2 mT during 3 minutes in establishment, multiplication, and acclimazation phases. Shoot and root lengths and leaf pair numbers of treated groups increased when compared to control; in addition to SOD, CAT, and APX activities of in vitro-treated groups showed a decrease in levels. Four months after the magnetic treatment was applied, the same parameters were evaluated. Shoot lengths, root lengths, the pair of leaves numbers, and CAT activity increased in treated plants. APX activity decreased in treatment seedlings, whereas SOD activity did not show a difference between experimental groups.
Face anti-spoofing based on image block difference and logistic regression analysis

Face recognition is one of the most widely used physiological biometrics. However, a printed photo or smartphone recording of a face can easily be presented to a face recognition camera to gain illegitimate access to a system. This paper presents an efficient anti-spoofing approach that can detect whether the face in front of the camera is genuine or fake. The proposed method uses the difference between pairwise discrete cosine transform coefficients and logistic regression as a machine learning algorithm. The experimental results show that the proposed approach outperforms the local binary patterns method, which is a representative technique in this research field.
Fast GPU-based computation of the sensitivity matrix for a PET list-mode OSEM algorithm

During the last decade, studies have shown that 3D list-mode ordered-subset expectation-maximization (LM-OSEM) algorithms for positron emission tomography (PET) reconstruction could be effectively computed and considerably accelerated by graphics processing unit (GPU) devices. However, most of these studies rely on pre-calculated sensitivity matrices. In many cases, the time required to compute this matrix can be longer than the reconstruction time itself. In fact, the relatively long time required for the calculation of the patient-specific sensitivity matrix is considered as one of the main obstacle in introducing a list-mode PET reconstruction algorithm for routine clinical use. The objective of this work is to accelerate a fully 3D LM-OSEM algorithm, including the calculation of the sensitivity matrix that accounts for the patient-specific attenuation and normalization corrections. For this purpose, sensitivity matrix calculations and list-mode OSEM reconstructions were implemented on GPUs, using the geometry of a commercial PET system. The system matrices were built on-the-fly by using an approach with multiple rays per detector pair. The reconstructions were performed for a volume of 188×188×57 voxels of 2×2×3.15 mm3 and for another volume of 144×144×57 voxels of 4×4×3.15 mm3. The time to compute the sensitivity matrix for the 188×188×57 array was 9 s while the LM-OSEM algorithm performed at a rate of 1.1 millions of events per second. For the 144×144×57 array, the respective numbers are 8 s for the sensitivity matrix and 0.8 million of events per second for the LM-OSEM step. This work lets envision fast reconstructions for advanced PET applications such as real time dynamic studies and parametric image reconstructions.