Miracle-dz/UniFAR-FTUs huggingface dataset:
Évaluation du NephroCheck® au sein d’une population à haut risque de lésion rénale aiguë : une étude prospective

Introduction : malgre les nouvelles definitions des lesions renales aigues (LRA), leur diagnostic reste difficile a definir et il persiste toujours un retard diagnostique. De nouveau biomarqueurs ont ainsi vu le jour dans le but d’ameliorer le delai diagnostique et d’essayer d’optimiser la prise en charge afin d’en diminuer les complications a court et a long terme. Le NephroCheck®, test urinaire, combine la mesure de deux nouveaux biomarqueurs : l’Insuline Growth factor binding protein 7 (IGFBP7) et le Tissue Inhibitor of Metallo Proteinase 2 (TIMP-2), tous deux marqueurs d’arret du cycle cellulaire. L’objectif etait d’evaluer les performances diagnostiques et pronostiques du NephroCheck® au sein d’une population de reanimation a haut risque de LRA. Methode : etude prospective observationnelle monocentrique de mars 2015 a juillet 2016 incluant tous les patients admis en reanimation presentant un syndrome de reponse inflammatoire systemique (SRIS). Un dosage de NephroCheck® etait realise a la 4e, 10e et 28e heure apres leur admission en reanimation. Le dosage de creatinine plasmatique etait realise a l’admission et quotidiennement jusqu’a J7. Les LRA etaient definies par la classification de KDIGO (KDIGO 1, 2 et 3). La performance diagnostique du NephroCheck® etait etudie. Le pronostic des patients etait evalue grâce au MAKE30 (Major Adverse Kidney Event), la necessite d’une epuration extra-renale et le risque de deces a J90. Les variations du NephroCheck® en fonction des injections d’aminosides ont egalement ete observees. Resultats : 148 patients ont ete inclus dans l’etude, 85 (57%) ont recu des aminosides. Au total 79 patients (50%) ont developpe une LRA et l’EER a ete necessaire chez 13 patients (9%). On retrouve une faible performance diagnostique du NephroCheck® pour predire la survenue d’une LRA dans les 24 a 48 heures avec une AUC-ROC de 0,63 [0,53-0,72]. Les performances pronostiques sont insuffisantes pour predire le risque de MAKE30 avec une AUC-ROC de 0,53 [0,43-0,63] mais apparait etre meilleure pour predire le recours a une EER avec une AUC-ROC de 0,74 [0,64-0,82]. On observe une augmentation significative du NephroCheck® apres une injection d’aminoside. Conclusion : nos resultats remettent en question la robustesse et l’utilite du NephroCheck® pour la prediction des LRA. Ses performances diagnostiques et pronostiques sont decevantes et restent insuffisantes pour en faire un marqueur infaillible de LRA au sein d’une population de reanimation a haut risque.
Chair Agency, Chair Preparation, and Academic Supports in Educational Leadership Doctoral Programs in the United States

Aim/Purpose The purpose of this exploratory qualitative case study was to understand dissertation chair agency, chair preparation, and academic supports provided by experienced Educational Leadership Ed.D. dissertation chairs in the United States. Background Previous research has identified attrition rates of 50-60 percent in education doctoral programs. This research helps identify the faculty profiles and academic supports provided by Educational Leadership faculty who have served on successful dissertation committees. Understanding these findings may help to improve retention and completion in other doctoral programs. Methodology This was an exploratory qualitative case study. Ten doctoral faculty who have successfully chaired 419 Ed.D. Educational Leadership dissertations at accredited U.S. colleges and universities were interviewed. Data were analyzed using the constant comparative method. Contribution The findings from this study contribute to the body of knowledge on doctoral retention and dissertation completion by providing information on promising practices from the perspective of dissertation chairs. Findings While successful dissertation chairs exhibited expertise as researchers, seven of the ten participants reported that they had limited training for Chair Agency, Chair Preparation, and Academic Supports 112 chairing dissertations. Academic supports included coursework that was organized coherently with a focus on opportunities for substantive feedback, writing support and research methodology. Recommendations for Practitioners Dissertation chairs should utilize their agency to ensure that the program has the proper resources to support doctoral education. This includes adequate writing support for graduate students, courses taught by faculty who are engaged in research and understand the requirements for completing a dissertation, and protecting faculty time so that they are able to provide students substantive feedback within coursework and at the dissertation phase. Recommendation for Researchers Researchers should continue to explore the causes of attrition in doctoral programs and identify specific actions that can be taken to improve program completion rates. Impact on Society Increasingly U.S. institutions of higher learning are being called to validate their success and improve retention rates. Understanding the faculty profiles and academic supports utilized by successful doctoral faculty has the potential to improve retention and thereby increase completion rates and consequentially alleviate the stressors that ABD students experience. Future Research Future research could focus on expanding the findings of this study by exploring the perspectives of faculty based on institution type and examining how socio-emotional factors such as student-student and faculty-student relationships are intentionally established in programs with high graduation rates.
CP-184 Correlations of vancomycin clearance during intermittent infusion with measured and estimated creatinine clearance in critically ill patients: 6 hour urine collection may be beneficial

Background Although vancomycin dosing recommendations are based on creatinine clearance estimated using the Cockcroft–Gault formula, it may not be optimal for critically ill patients due to their physiologic changes. A direct measure of creatinine clearance can provide more accurate information on renal function and dose adjustment of vancomycin. Purpose The objective of the current study was to determine vancomycin clearance during intermittent infusion and to explore its correlations with measured and estimated creatinine clearance in critically ill patients with normal renal function. Material and methods 20 critically ill patients who received treatment with vancomycin intermittent infusion were enrolled (16 men, 4 women, age 46.8±19.8 years, body mass index 24.0±2.8 kg/m2, estimated glomerular filtration rate (eGFR) 108.0±44.3 mL/min, Acute Physiology and Chronic Health Evaluation (APACHE) II score 12.7±5.0 at admission). Vancomycin clearance (CLvan) was determined 1–2 times for each patient during the study (n=32). Its correlation with measured creatinine clearance in 6 hour urine (CL6-h) and estimated creatinine clearance from the Cockcroft–Gault formula (CLCG) was investigated. Results Data analysis revealed that CL6-h was a stronger predictor of CLvan rather than CLCG (Pearson coefficient correlation=0.83 vs 0.67; p<0.001). The relationship between CLvan and CL6-h was utilised to develop the following equation to estimate clearance of vancomycin in the critically ill patients without renal impairment: CLvan (mL/min)=26.55+0.73 CL6-h ( mL/min). Conclusion Measured creatinine clearance estimated from a 6 hour urine collection is a simple test that provides more reliable and practical information compared with the Cockcroft–Gault formula for vancomycin dose adjustment in critically ill patients with normal renal function. References and/or acknowledgements We would like to acknowledge all of the patients who agreed to contribute to the study. No conflict of interest
Risk factors for uterine fibroids: reduced risk associated with oral contraceptives

As far as we can ascertain the presence of fibroids has not been regarded as a contraindication to oral contraceptive (OC) use in Britain although some authorities suggest that women with fibroids who are taking the pill should be kept under observation. Caution is however also counselled about the use of IUDs in women with fibroids so any patient selection is likely to have operated in relation to this birth control method as well; as we noted in our paper there was no relationship between use of an IUD and fibroids in our study. Perhaps more importantly all women giving a history of fibroids on recruitment to our study were excluded from the analysis (not just those with pathologically confirmed fibroids as incorrectly stated in our paper). 2 further points seem worth making. Firstly the fact that we found that the protective effect of OCs against fibroids increased with duration of use argues against selection bias being the explanation. Secondly a substantial number of women in our study 1st started to use OCs during the follow up period having switched from a diaphragm or an IUD. We found no evidence to suggest that OCs are likely to provoke fibroid complications either in the early months of use or later. In our view Dr. Ratners hypothesis does not offer an explanation for our findings. We would like to take this opportunity to point out a number of typographical errors in the article as printed: on page 360 column 2 line 4 from bottom of page should have read "with either 0.25 mg or 0.15 mg levonorgestrel brands"; in table 4 the drug name in the 2nd column should have been lynestrenol not lynestrol; and on page 361 column 1 line 5 from bottom of page should have read: "between cervicitis and fibroids" not "between urinary tract infections and fibroids. " (full text)
REDESENHO DOS PROCESSOS DE NEGÓCIOS COM BASE EM UMA ANÁLISE ABC MULTICRITÉRIO: Estudo de caso em uma prestadora de serviços no setor de asseio e conservação

Pompilio Guimarães Reis Filho (Institutos Superiores de Ensino do CENSA (ISECENSA) ) pompilio_reis@hotmail.com Rafaela Landim Gomes Siqueira (Instituto Tecnológico, das Ciências Sociais Aplicadas e da Saúde ) rafa_landim6@hotmail.com Romeu e Silva Neto (Instituto Tecnológico, das Ciências Sociais Aplicadas e da Saúde ) romeuesilvaneto@gmail.com Henrique Rego Monteiro da Hora (Instituto Federal Fluminense ) dahora@gmail.com Simone Vasconcelos Silva (Instituto Federal Fluminense ) simonevsinfo@yahoo.com. br
A Sm-MOF/GO nanocomposite membrane for efficient organic dye removal from wastewater

The instability of graphene oxide (GO) membranes in aqueous solutions restricts their application in wastewater treatment through the membrane separation technology. In this work, a nanocomposite membrane (Sm-MOF/GO) composed of samarium metal–organic frameworks (Sm-MOFs) and GO nanosheets was successfully fabricated via the filtration of the corresponding Sm-MOF/GO dispersions. The in situ growth of Sm-MOF with aqueous stability on the GO sheets prevented the adjacent GO layers from expanding in aqueous solutions, thus endowing the prepared Sm-MOF/GO membrane with a stable membrane skeleton structure. Besides, the successful loading of Sm-MOF enlarged the layer space of the composite membrane, which was beneficial for higher permeance. The optimization of the Sm-MOF loading contents was also investigated to prepare M-X (where X represents the mass ratio of the MOF raw material to the total mass of the reactants). Subsequently, the fabricated M-0.31 possessed a high permeance of 26 L m−2 h−1 bar−1, which was 3 times higher than that of a pure GO membrane; moreover, high rejections (>91%) to rhodamine B and methylene blue were obtained. After continuous 5.5 h filtration, the excellent rejection was still maintained as expected, indicating the long-term stability of M-0.31.
Habitat selection and genetic diversity of a reintroduced ‘refugee species’

A ‘refugee’ species is one with a current distribution that has been restricted to a subset of their former niche by threatening processes. Conservation opportunities for such species can be limited by a poor understanding of habitat requirements, where habitat models are based on current distributions and not the innate capacity of the animal to survive where threats are managed. We examined patterns of habitat selection by a putative refugee species, the threatened New Holland mouse Pseudomys novaehollandiae, following reintroduction into historic habitat (habitat that corresponds to a currently unoccupied component of its former niche). Current New Holland mouse populations exist predominantly in coastal heath habitat of select vegetation and fire history, and these environmental conditions differ greatly to those found across the species historical distribution. Using a novel, non‐invasive method of detection for the species, we investigated patterns of habitat selection following reintroduction into historic habitat, where the species primary threat of exotic predators has been removed. We also assessed the changes in genetic diversity measures across three stages of the reintroduction process (before, during and after) using microsatellite markers, to reflect on past efforts in maintaining genetic diversity. We found that historic habitat can still support New Holland mouse populations and identified more diverse potential habitat for the species. We also identified loss of alleles and an increased inbreeding coefficient at the captive breeding stage, but these findings were not statistically significant. This study expands on our limited understanding of habitat requirements and the fundamental niche of the New Holland mouse, highlighting new potential conservation opportunities.
Chromosome segregation is driven by joint microtubule sliding action of kinesins KIF4A and EG5

Successful cell division requires proper chromosome segregation during anaphase. Forces required for chromosome segregation in human cells are linked to sliding of antiparallel microtubules and sliding capacity has been demonstrated in vitro for multiple motor proteins, but the molecular mechanism of sliding in the spindle of human cells remains unknown. Using combined depletion and inactivation assays to explore redundancy between multiple targets together with CRISPR technology, we found that PRC1-dependent motor KIF4A/kinesin-4, together with EG5/kinesin-5 motor is essential for spindle elongation in human cells. Photoactivation of tubulin and super-resolution microscopy show that perturbation of both proteins impairs sliding, while decreased midzone microtubule stability cannot explain the observed anaphase arrest. Thus, two independent sliding modules power sliding mechanism that drives spindle elongation in human cells.
Design and Evaluation of a Mobile Phone-based Remote Patient Monitoring System for Heart Failure Management: A Focus on Self-care

Methods to improve self-care and clinical management of heart failure are required, especially in light of the anticipated increase in heart failure prevalence and associated high costs. Remote patient monitoring (RPM) has been shown to improve heart failure outcomes, but the feasibility and efficacy of mobile phone-based RPM systems are still unknown. The main objectives of this research were to investigate the optimal design of a mobile phone-based RPM system, and to determine the effects of the system on selfcare, clinical management, and health outcomes. A mobile phone-based RPM system was first developed using a user-centric design process. It was then evaluated with a six-month randomized controlled trial consisting of 100 patients attending a heart function clinic. The quality of life improved only for the intervention group, but both intervention and control groups improved with respect to
STEREOTACTIC RADIATION THERAPY IN PITUITARY ADENOMAS, IS IT BETTER THAN CONVENTIONAL RADIATION THERAPY?

Pituitary radiotherapy (RT) has undergone important progress in the last decades due to the development of new stereotactic techniques which provide more precise tumour targeting with less overall radiation received by the adjacent brain structures. Pituitary surgery is usually first-line therapy in most patients with nonfunctioning (NFPA) and functioning adenomas (except for prolactinomas and large growth hormone (GH) secreting adenomas), while RT is used as second or third-line therapy. The benefits of RT (tumour volume control and, in functional tumours, decreased hormonal secretion) are hampered by the long latency of the effect and the potential side effects. This review presents the updates in the efficacy and safety of the new stereotactic radiation techniques in patients with NFPA, GH-, ACTH- or PRL-secreting pituitary adenomas. Methods A systematic review was performed using PubMed and articles/abstracts and reviews detailing RT in pituitary adenomas from 2000 to 2017 were included. Results Stereotactic radiosurgery (SRS) and fractionated stereotactic RT (FSRT) provide high rates of tumour control i.e. stable or decrease in tumour size, in all types of pituitary adenomas (median 92 - 98%) at 5 years. Endocrinological remission is however significantly lower: 44-52% in acromegaly, 54-64% in Cushing's disease and around 30% in prolactinomas at 5 years. The rate of new hypopituitarism varies from 10% to 50% at 5 years in all tumour types and as expected increases with the duration of follow-up (FU). The risk for other radiation-induced complications is usually low (0-5% for new visual deficits, cranial nerves damage or brain radionecrosis and extremely low for secondary brain tumours), however longer FU is needed to determine rates of secondary tumours. Notably, in acromegaly, there may be a higher risk for stroke with FSRT. Conclusion Stereotactic radiotherapy can be an effective treatment option for patients with persistent or recurrent pituitary adenomas after unsuccessful surgery (especially if residual tumour is enlarging) and/or resistance or unavailability of medical therapy. Comparison with conventional radiation therapy (CRT) is rather difficult, due to the substantial heterogeneity of the studies. In order to evaluate the potential brain-sparing effect of the new stereotactic techniques, suggested by the current data, long-term studies evaluating secondary morbidity and mortality are needed.
Throughput Optimization of Multichannel Allocation Mechanism under Interference Constraint for Hybrid Overlay/underlay Cognitive Radio Networks with Energy Harvesting

By harvesting energy from ambient radio frequency (RF) signals, significant progress has been achieved in wireless networks self-maintaining their life cycles. Motivated by this and improved spectrum reuse by combined use of overlay/underlay modes of cognitive radio networks (CRNs), this paper proposes a novel multi-channel (m-channel) allocation performance maximization algorithm for low-power mobiles. CRNs, called secondary transmitters (STs), can harvest energy from RF signals by nearby active primary transmitters (PTs). In the proposed scheme, PTs and STs are distributed as independent homogeneous Poisson point processes and contact their receivers at fixed distances. Each PT contains a guard zone to protect its intended receiver from ST interference, and provides RF energy to STs located in its harvesting zone. Prioritization of STs during opportunistic allocation of channels is critical as properties like energy level and harvesting capability improve channel distribution performance. A novel metric is proposed that prioritizes STs based on initial energy levels, harvesting capability, and number of channels through which they can transmit. For comparison, three algorithms were considered: a greedy mechanism for m-channel allocation of hybrid CRNs without harvesting, the proposed m-channel allocation schemes based on maximum independent sets (MIS), and the proposed metric of hybrid CRNs with harvesting capability. The simulations show that the proposed m-channel allocation method based on MIS outperforms the greedy algorithm. The proposed m-channel allocation using the proposed metric on hybrid CRNs with energy harvesting ability produced the best performance of the three methods, proving the superiority of the proposed algorithm.
Physiology of the Eye

Just as is the case with entropy the size of a text-book is always increasing, and in view of the advances in this subject during the past decade one must congratulate the author on having been able to compress so much into a modest increase of I50 pages (as compared with the 2nd edition which appeared in I963). This ability to give an overall conspectus of many different aspects of physiology is one for which Dr. Davson is well known and one which is particularly important in the present instance. The physiology of the eye involves amongst other things excursions into electroand neurophysiology (Sections II and IV), optics (Section V), and the physiology of muscles (Section III), and must range from structural anatomy to questions of perception and experimental psychology. The author covers this wide variety of subjects admirably. The first two sections ("Vegetative Physiology and Biochemistry of the Eye" and "The Mechanisms of Vision") have undergone the greatest expansion compared with previous editions, and it is good to see a discussion of much recent work (as for instance that of Blakemore and -of Hubel and Wiesel) on the neurophysiology of perception and binocular vision in Section IV. The section on visual pigments could have been more detailed and more might have been included on the role of the retinal pigment epithelium in the metabolism of material from rod outer-segments. Another point of criticism concerns some of the figures; some of the half-tone reproductions are below standard, particularly Figs I3, 41, 313, and 3I4, where the contrast and detail leave much to be desired. Each chapter is followed by a very full list of references, making it possible to find the authority for any point cited in the preceding text, and while this has undoubtedly added to the bulk of the volume it makes it invaluable for reference. This indeed renders the work rather more than a student's text-book and it is, in the opinion of the present reviewer, a necessity for any institution or any investigator seriously concerned with research on the eye. It obviously contains more information than is likely to be required by students reading for professional qualifications in ophthalmology, but this should not deter them from obtaining the book which for years to come should provide them with much valuable information on the scientific background of their specialty.
Mechanical considerations in impaction bone grafting

In impaction grafting of contained bone defects after revision joint arthroplasty the graft behaves as a friable aggregate and its resistance to complex forces depends on grading, normal load and compaction. Bone mills in current use produce a distribution of particle sizes more uniform than is desirable for maximising resistance to shear stresses. We have performed experiments in vitro using morsellised allograft bone from the femoral head which have shown that its mechanical properties improve with increasing normal load and with increasing shear strains (strain hardening). The mechanical strength also increases with increasing compaction energy, and with the addition of bioglass particles to make good the deficiency in small and very small fragments. Donor femoral heads may be milled while frozen without affecting the profile of the particle size. Osteoporotic femoral heads provide a similar grading of sizes, although fewer particles are obtained from each specimen. Our findings have implications for current practice and for the future development of materials and techniques.