Miracle-dz/UniFAR-FTUs huggingface dataset:
Orally-based information

Purpose – The purpose of this paper is to explore a new research area: orally‐based information.Design/methodology/approach – The study utilizes a social constructionist approach. The social constructionist meta‐theory, which holds that contributions to knowledge can be made orally, frames it.Findings – The paper explicates how orality, or word‐of‐mouth transactions, conveys information; describes approaches for investigating orally‐based information; and articulates the need for future information behavior investigations that focus on orality.Research limitations/implications – The research exploration focuses on face‐to‐face oral data. It calls for increased attention to orally‐based information, and offers tentative suggestions for accomplishing this goal.Practical implications – The results provide insight that assist in understanding how orally‐based information intersects with information behavior, knowledge management, information policy, cultural heritage, and professional development that involve.
VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801.

PURPOSE Our previous phase II trial for treating human T-lymphotropic virus type I-associated adult T-cell leukemia-lymphoma (ATLL) with vincristine, cyclophosphamide, doxorubicin, and prednisone (VCAP), doxorubicin, ranimustine, and prednisone (AMP), and vindesine, etoposide, carboplatin, and prednisone (VECP) showed promising results. To test the superiority of VCAP-AMP-VECP over biweekly cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), we conducted a randomized controlled trial exclusively for ATLL. PATIENTS AND METHODS Previously untreated patients with aggressive ATLL were assigned to receive either six courses of VCAP-AMP-VECP every 4 weeks or eight courses of biweekly CHOP. Both treatments were supported with granulocyte colony-stimulating factor and intrathecal prophylaxis. RESULTS A total of 118 patients were enrolled. The complete response (CR) rate was higher in the VCAP-AMP-VECP arm than in biweekly CHOP arm (40% v 25%, respectively; P = .020). Progression-free survival rate at 1 year was 28% in the VCAP-AMP-VECP arm compared with 16% in the CHOP arm (P = .100, two-sided P = .200). Overall survival (OS) at 3 years was 24% in the VCAP-AMP-VECP arm and 13% in the CHOP arm (P = .085, two-sided P = .169). For VCAP-AMP-VECP versus biweekly CHOP, grade 4 neutropenia, grade 4 thrombocytopenia, and grade 3 or 4 infection rates were 98% v 83%, 74% v 17%, and 32% v 15%, respectively. There were three toxic deaths in the VCAP-AMP-VECP arm. CONCLUSION The longer OS at 3 years and higher CR rate with VCAP-AMP-VECP compared with biweekly CHOP suggest that VCAP-AMP-VECP might be a more effective regimen at the expense of higher toxicities, providing the basis for future investigations in the treatment of ATLL.
Selective knockdown of AT 1 receptors by RNA interference inhibits Val 5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells

Li XC, Zhuo JL. Selective knockdown of AT1 receptors by RNA interference inhibits Val-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells. Am J Physiol Cell Physiol 293: C367–C378, 2007. First published April, 11, 2007; doi:10.1152/ajpcell.00463. 2006. —Receptor-mediated endocytosis of extracellular ANG II has been suggested to play an important role in the regulation of proximal tubule cell (PTC) function. Using immortalized rabbit PTCs as an in vitro cell culture model, we tested the hypothesis that extracellular ANG II is taken up by PTCs through angiotensin type 1 receptor (AT1; or AT1a) receptor-mediated endocytosis and that inhibition of ANG II endocytosis using a selective AT1 receptor small-interfering RNA (siRNA; AT1R siRNA) or endocytotic inhibitors exerts a physiological effect on total and apical sodium and hydrogen exchanger isoform 3 (NHE-3) protein abundance. Western blots and live cell imaging with FITC-labeled ANG II confirmed that transfection of PTCs with a human specific AT1R siRNA for 48 h selectively knocked down AT1 receptor protein by 76 5% (P 0.01), whereas transfection with a scrambled siRNA had little effect. In nontransfected PTCs, exposure to extracellular ANG II (1 nM) for 60 min at 37°C increased intracellular ANG II accumulation by 67% (control: 566 55 vs. ANG II: 943 160 pg/mg protein, P 0.05) and induced mitogen-activated protein kinase extracellular signal-regulated kinase (ERK) 1/2 phosphorylation (163 15% of control, P 0.01). AT1R siRNA reduced ANG II endocytosis to a level similar to losartan, which blocks cell surface AT1 receptors (557 37 pg/mg protein, P 0.05 vs. ANG II), or to colchicine, which disrupts cytoskeleton microtubules (613 12 pg/mg protein, P 0.05 vs. ANG II). AT1R siRNA, losartan, and colchicine all attenuated ANG II-induced ERK1/2 activation and total cell lysate and apical membrane NHE-3 abundance. The scrambled siRNA had no effect on ANG II endocytosis, ERK1/2 activation, or NHE-3 expression. These results suggest that AT1 receptor-mediated endocytosis of extracellular ANG II may regulate proximal tubule sodium transport by increasing total and apical NHE-3 proteins.
GLOBAL INNOVATION MANAGEMENT IN WIRELESS COMMUNICATIONS INDUSTRY

Companies competing in global markets are facing the challenge to globalize their innovation processes. They need to identify new market needs and to access evolving markets around the globe. Leaving those markets unchallenged to competitors could impact their home markets. To serve these markets with innovative products they have to simultaneously identify, access and develop new technological know-how all over the globe. Today many countries are investing heavily in technology related research to support their industries. Hence important new technological know-how is no longer limited to US, Europe and Japan. R&D leaders and researchers struggle to understand global innovation competence and its impact on their business. This paper analyzes global innovation competence in the Wireless Communication Industry. It is no accident that industry leaders lost their leadership positions within just a few years. The authors examine the industry evolution in this context and discuss the basic problems of the need to implement processes supporting innovations in a global setting. Wireless communications companies are competing more and more on the basis of their competence to innovate on the global level. This competence requires many different skills. Strategies, organizational structures and effective processes are needed to access and integrate geographically dispersed knowledge in order to maximize the global innovation competence. It also requires a capability to manage the relationships between culturally diverse institutions, including standards and regulatory bodies, and knowledge/technology clusters and their interactions.
The Role of Innovation Intermediaries in Innovation Systems

The paper investigates the role of innovation intermediaries in sector-specific regional innovation systems. Innovation is viewed as a non-linear, iterative process and open process involving multiple actors from different parts of the innovation system. The paper studies in particular innovation intermediaries that provide support to firms in the regional innovation system through the fulfillment of key innovation system functions. The implication of the fulfillment of innovation system functions by innovation intermediaries in the Scandinavian food sector context is examined through in-depth interviews and analysis of secondary documents. It concludes with a discussion on the potential of enabling innovation intermediaries to play a more strategic role in regional innovation system.
Low-intensity microwave radiation and the virulence of Agrobacterium tumefaciens strain B6

When virulent cells of Agrobacterium tumefaciens strain B6 were exposed to low-level microwave radiation at a frequency of 10,000 MHz and an intensity of 0.58 mW/cm2 for 30 to 120 min, a 30 to 60% decrease in their ability to produce tumors on potato and turnip disks was observed. This microwave exposure did not affect the viability of these bacteria or their ability to attach to a tumor-binding site nor did it induce thermal shock. This loss of virulence was reversible within 12 h.
Analysis of cognition commonality using descriptive corpus

This paper aims to discover the cognition commonality among several people while observing a physical object by analysis of large amount of descriptive about the object. The methodology contains four major tasks: (1) object description corpus collection, (2) linguistic processing of the corpus, (3) analysis of the descriptive sentences, and (4) building the cognition commonality model. The description of an object can be decomposed into several partial structure patterns (PSP) which are the combination of major component keywords plus the corresponding attributes. Perform statistical analysis on the PSP reveal the structural of the cognition commonality about the target object. Taking the wild birds in Taiwan as experiment target, our study had discovered the common structure of how an object is described. The results are useful as the authors are building a bird inquiring system which allows users to query about a specific bird by input the cognized
Big data in healthcare: What is it used for?

Big data analytics is a growth area with the potential to provide useful insight in healthcare. Whilst many dimensions of big data still present issues in its use and adoption, such as managing the volume, variety, velocity, veracity, and value, the accuracy, integrity, and semantic interpretation are of greater concern in clinical application. However, such challenges have not deterred the use and exploration of big data as an evidence source in healthcare. This drives the need to investigate healthcare information to control and reduce the burgeoning cost of healthcare, as well as to seek evidence to improve patient outcomes. Whilst there are a number of well-publicised examples of the use of big data in health, such as Google Flu and HealthMap, there is no general classification of its uses to date. This study used a systemic review methodology to create a categorisation of big data use in healthcare. The results indicate that the natural classification is not clinical application based, rather it falls into four broad categories: administration and delivery, clinical decision support (with a sub category of clinical information), consumer behaviour, and support services. Further, the results demonstrate that the use of big data in all examples in the literature is not singular in its approach and each study covers multiple use and application areas. This study provides a baseline to assess the proliferation of the use of big data in healthcare and can assist in the understanding the breadth of big data applications.
Expression Pattern of Chemokine Receptors and Chemokine Release in Inflammatory Erythroderma and Sézary Syndrome

Background: Erythroderma can be caused by inflammatory dermatoses or cutaneous T-cell lymphoma. Even if chemokines and their receptors are involved in the skin-selective lymphocyte recruitment, their role in inflammatory erythroderma is yet unclear. Objective: To evaluate the chemokine release (TARC, MDC, IP-10) and to define the expression pattern of Th1- (CCR5, CXCR3) and Th2-related (CCR4) chemokine receptors in inflammatory erythroderma and Sézary syndrome (SS). Materials and Methods: Flow cytometry has been carried out on both circulating and skin-infiltrating T lymphocytes; serum chemokine levels have been evaluated using ELISA techniques. Results: CCR4, CCR5 and CXCR3 were expressed on about 40% of peripheral blood lymphocytes and on the majority of skin-infiltrating lymphocytes in the inflammatory erythroderma patients, whereas the leukemic CD4+CD26– subpopulation in SS was characterized by a high CCR4 expression without a concurrent increase in CCR5 or CXCR3. TARC, MDC and IP-10 serum levels were significantly increased in both erythrodermic and SS patients. Conclusions: Our results confirm that SS is a Th2 disorder with a selective expression of CCR4, whereas inflammatory erythroderma shares an overexpression of both Th1- and Th2-related chemokine receptors, suggesting an activation of different pathways driving reactive lymphocytes to the skin.
A new AC technique for accurate determination of channel charge and mobility in very thin gate MOSFET's

A new method is described for determining the channel charge and mobility of a MOS transistor as a function of gate bias from the ac admittance measurements. The admittance of the conduction channel of the MOSFET is derived from a transmission line model. The peaks of theG/\omegaversus ω curves are used to deduce gate-channel capacitance and mobility. The mobile carrier density and mobility in very thin-oxide MOSFET's can be measured more accurately using this ac method, since a zero lateral field and a uniform mobile charge distribution along the channel is maintained with zero drain-source voltage and interface trap effects are reduced by using high test frequencies. Measured data on the electron mobility versus gate voltage are presented for 90-A gate dielectric MOS transistors.
Low-cost 60 GHz 3D printed lens fed by a planar source with WR15 transition integrated on FR4 PCB

We present in this paper a cost-effective, high-gain V-band lens antenna system. The lens is illuminated by a planar antenna integrated on standard FR4 PCB along with a built-in connector using a fin-line microstrip-to-waveguide transition (enabling WR15 waveguide connection). The lens has an elliptical dome-type design destined to be manufactured in ABS plastic using 3D printing. The proposed antenna solution achieves high gain (> 28 dBi) in V band (57–66 GHz) and targets low-cost backhaul links that will be required in 5G small cells.
Pay-as-you-go financing: the volatility of the financial equilibrium of the Pension Funds

In order to simplify let us consider a compulsory pension fund, which provides only old-age pensions at the attainment of the retirement age. It is assumed that in any year t-h all members enter the scheme at age x and the number of the new entrants is equal to h t N − . Under these conditions, at the time t> x (stationary state), the amount of contributions and benefits will be expressed as follows:
Wideband phase shifter with stub loaded transmission line

This paper presents a modified architecture for a wide band phase shifter. The proposed design consists of a main line with a T-network and a modified conventional reference line with an L-network. For quick prototyping, the design examples are demonstrated to work for several phase shifts upto 90° for a wide bandwidth. To verify the given design procedure, a 90° phase shifter, working at 1.8 GHz, is prototyped on Rogers5880 with substrate thickness of 1.575 mm and dielectric constant of 2.2. The prototype is able to provide the 90° phase difference over a bandwidth of 106% considering only 3° of phase ripples. The measured results matches well with the simulated results and thus verifies the design technique.
Healing After Columbine: Reflections of Psychoanalytic Responders To Community Trauma

Following the shootings at Columbine High School on April 20, 1999, the Denver Psychoanalytic Society provided both immediate and long-term interventions to those closely impacted by the tragedy. In this effort, analytically trained volunteers faced many personal challenges and role adjustments. To address these issues a reflective study group was formed twenty months after the traumatic event. Group discussions revealed a surprising number of residual symptoms from secondary trauma, as well as opportunities for shared coping among analysts. Little has been written about the very human and subjective responses of analysts in such circumstances. These experiences may be helpful to others in today's world of terrorism and unexpected violent events.
Aggregation of Cricket Activity in Response to Resource Addition Increases Local Diversity

Crickets are often found feeding on fallen fruits among forest litter. Fruits and other sugar-rich resources are not homogeneously distributed, nor are they always available. We therefore expect that crickets dwelling in forest litter have a limited supply of sugar-rich resource, and will perceive this and displace towards resource-supplemented sites. Here we evaluate how sugar availability affects cricket species richness and abundance in old-growth Atlantic forest by spraying sugarcane syrup on leaf litter, simulating increasing availability, and collecting crickets via pitfall trapping. We found an asymptotic positive association between resource addition and species richness, and an interaction between resource addition and species identity on cricket abundance, which indicates differential effects of resource addition among cricket species. Our results indicate that 12 of the 13 cricket species present in forest litter are maintained at low densities by resource scarcity; this highlights sugar-rich resource as a short-term driver of litter cricket community structure in tropical forests. When resource was experimentally increased, species richness increased due to behavioral displacement. We present evidence that the density of many species is limited by resource scarcity and, when resources are added, behavioral displacement promotes increased species packing and alters species composition. Further, our findings have technical applicability for increasing sampling efficiency of local cricket diversity in studies aiming to estimate species richness, but with no regard to local environmental drivers or species-abundance characteristics.
Informing and transforming on the web: an empirical study of response to banner ads for functional and expressive products

This article examines the effectiveness of banner ads for functional and expressive products. The results from a large empirical study show that there are major differences between the performances of banner ads for the two product types. Banner ads can work as transporters of consumers to target ads and as ads in themselves with direct communication effects. The study indicates that banner ads work better as transporters to target ads for functional products, whereas banner ads for expressive products work better through ad impressions. It is also found that consumers who click on banner ads for expressive products tend to be greater users of and be more positively disposed towards the brand. The differences between consumers' responses to advertising for the two product types, conceptualised as informing and transforming on the web, are discussed.
Life-Threatening Respiratory Tract Disease with Human Bocavirus-1 Infection in a 4-Year-Old Child

ABSTRACT The disease spectrum associated with human bocavirus-1 infection remains to be fully defined. We report a case of bocavirus-1-associated bronchiolitis, leading to severe respiratory failure and extracorporeal membrane oxygenation in a 4-year-old child, and suggest blood testing for human bocavirus-1 in children with severe respiratory tract infection.
Accurate RGB-D camera based on structured light techniques

Recently, RGB-D cameras have been widely used to perform 6-D pose estimation of target objects for robotic manipulation. Such applications require accuracy shape measurements for 3-D modeling of the objects. In this work, we develop an RGB-D camera based on the structured light (SL) techniques with gray-code encoding and decoding. The intrinsic and extrinsic parameters of the camera system are determined by a calibration process. 3-D reconstruction of the object surface is based on a ray triangulation principle by computing the intersection point. In the implementation, we construct an RGB-D sensing system with an industrial camera and a digital light projector. In the experiments, real world objects are used to test the feasibility of the proposed method. The evaluation carried out using planar objects has demonstrated the accuracy of our RGB-D camera system.
Temporal dynamics of the cellular, humoral and cytokine responses in chickens during primary and secondary infection with Salmonella enterica serovar Typhimurium

Salmonella enterica serovar Typhimurium (S. Typhimurium) infections cause systemic disease in the young chick, whereas in the older chicken the infection is mainly restricted to the intestine. Chickens infected orally with S. Typhimurium (F98) at 6 weeks of age and re-infected 10 weeks later were monitored for antibody production, T-cell proliferation and production of selected cytokines (interferon-γ, interleukin-1β and transforming growth factor-β4). A strong coordinated antigen-specific humoral and cellular immune response was temporally linked to resolution of the primary infection. Enhanced levels of mRNA encoding the cytokines, interleukin-1β, transforming growth factor-β4 and interferon-γ were also evident during early phases of primary infection. Secondary infection was restricted to the intestine and of shorter duration than primary infection. Splenic immune responses were not further enhanced by secondary infection; indeed, antigen-specific proliferation was significantly reduced at 1 day after secondary infection, which may be interpreted as the trafficking of reactive T cells from the spleen to the gut.
CONTRACTING STRATEGIES FOR EU TRACEABILITY REQUIREMENTS

A principal-agent problem was specified to define the equilibrium solution of a contracting strategy for a U.S. supplier exporting wheat to meet EU traceability requirements. The buyer (principal) offers a contract, the supplier (agent) accepts the contract, and then the supplier decides whether to offer a contract to the farmer. Nature at each level of the supply chain represents uncertainty due to adventitious commingling and imperfect information. Results indicate farmers would require 9 c/bu and suppliers 8 c/bu to induce their participation in the contracting strategy.
A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans.

BACKGROUND CYP27B1 hydroxylase catalyzes the conversion of 25 hydroxyvitamin D(3) (25OHD(3)) to 1,25(OH)(2)D(3), the most active natural vitamin D metabolite, which plays a role in the regulation of immunity and cell proliferation. We therefore investigated two single nucleotide polymorphisms in the CYP27B1 hydroxylase gene for an association with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus. METHODS Patients with Addison's disease (n=124), Hashimoto's thyroiditis (n=139), Graves' disease (n=334), type 1 diabetes mellitus (n=252) and healthy controls (n=320) were genotyped for the promoter (-1260) C/A polymorphism and for the intron 6 (+2838) C/T polymorphism of the CYP27B1 gene. Patients and controls were compared using genotype-wise and allele-wise X(2) testing. RESULTS A significant association was found between allelic variation of the promoter (-1260) C/A polymorphism and Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus (P=0.0062, P=0.0173, P=0.0094 and P=0.0028 respectively). Significant differences were also observed for the intron 6 (+2838) C/T polymorphism (P=0.0058) in Hashimoto's thyroiditis but not for the other autoimmune endocrine diseases. CONCLUSIONS The CYP27B1 promoter (-1260) C/A polymorphism appears to be associated with endocrine autoimmune diseases but the CYP27B1 intron 6 (+2838) C/T polymorphism appears to be associated only with Hashimoto's thyroiditis. These results imply a regulatory difference of the CYP27B1 hydroxylase to predispose to endocrine autoimmunity.