Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of rheumatoid arthritis with interstitial lung disease by in removal stasis.

Objective: To observe the effect of removal stasis on rheumatoid arthritis (RA) with interstitial lung disease (ILd). Methods: 80 Patients were divided into treatment group (60 cases) and control group (20 cases). Patients in the treatment group were treated by Dantaohuaxian Decoction and prednisone 0.5mg. kg-1.d-1, Azathioprine 50mg/d. Patients in the control group were treated by prednisone 0.5mg. kg-1.d-1, Azathioprine only. The therapeutic course for both groups was three months. Results: The results of blood gas analysis, pulmonary function tests, ESR showed that the treatment group was better than the control group (P0.05). There was significant difference of total effective rate in symptoms between the treatment group (73.33%) and the the control group (45.0%). Conclusion: Removal stasis with Dantaohuaxian Decoction was effective on rheumatoid arthritis patients with interstitial lung disease.
Venlafaxine for treatment of chemotherapy-induced neuropathic pain

Peripheral neuropathy (PN) is a common toxicity of frequently used chemotherapy agents. Pain in these patients may sometimes be a difficult problem to manage. To palliate symptoms we administered venlafaxine in our patients suffering from chemotherapy induced peripheral neuropathy. 12 patients with cancer, 10 of whom had unremitting painful chemotherapy-induced peripheral neuropathy and 2 had been suffering from severe paresthesia, numbness, walking difficulty without pain, used 75 mg venlafaxine extended release capsules for 8 weeks. Symptoms and adverse effects were evaluated before and after treatment. Median VAS score declined to 0 at the 8 th week from its baseline median value of 45. This decline in pain severity was significant (P≤0.001). Other symptoms did not improve. As a side effect, drowsiness increased from 0% of cases reported baseline to 75% at the 8 th week (P=0.041). Two patients gave up due to the toxicity. Venlafaxine seems to effectively improve chemotherapy induced neuropathic pain with moderate manageable toxicity. This observation warrants further study for comparison with other antidepressants. [Turk J Cancer 2004;34(3):110-113]
2,5-Bis{2,2-bis[4-(dimethylamino)phenyl]ethenyl}-N,N′-diphenyl-N,N′-dipropylbenzene-1,4-diamine

The title compound, C60H68N6, was prepared by Horner olefination of a terephthaldialdehyde and a diarylmethyl phosphonate. There is one half-molecule, located on an inversion centre, in the asymmetric unit. The dihedral angle between the plane of the vinylene unit and the central ring is 36.79 (15)°, while those between the vinylene unit and the lateral phenyl rings are 53.04 (10) and 53.74 (9)°.
Comparing the Effect of Motivational Interviewing and Standard Nutrition Education on Promoting Adherence to Weight Loss Program in Obese and Overweight Women: A Randomized Clinical Trial

Background and purpose: Prevalence of overweight and obesity is significantly increasing which imposes heavy costs on individuals and communities. Motivational interviewing is a client-based and direct approach to elevate intrinsic motivation and changing people's behavior by exploring and resolving ambiguities. The health benefits of motivational interviewing have been widely acknowledged. Our survey aimed to evaluate the effects of motivational interviewing on promoting adherence for weight loss program in overweight and obese women. Materials and methods: In a randomized clinical trial we recruited 100 overweight and obese women attending a nutrition clinic. The subjects were randomly divided into a control group and intervention group (n=50 per group). Data was collected using a checklist in pre-test, 2 and 6 month follow-up. Data analysis was performed in SPSS (ver. 16) applying independent t-test and Repeated measure ANOVA. Results: The mean weights in the control and intervention groups were 75.9 ± 6.05 and 74.2 ± 6.95, respectively. Women in the intervention group participated more in motivational interviewing sessions (14.2 times vs. 9.6 times). They also completed the checklists for their dietary intake and physical exercise more than the control group (16.1cases vs. 9.8 cases). There was a significant difference in weight loss between the two groups (P<0.001). Conclusion: Motivational interviewing with usual weight loss education was found to have beneficial outcomes.
Navigator program for breast cancer trial recruitment and enrollment at a county hospital

598 Background: Only a small fraction of patients with breast cancer are enrolled on clinical trials, fewer from minority and underserved populations. Limited resources in county hospitals accentuate barriers to accrual. Methods: We designed a Patient Navigator program at the Breast Clinic at Parkland Hospital in Dallas, which serves a primarily Hispanic and African American population. Patients were identified at first diagnosis of breast cancer or at the time of recurrence. Demographic and clinical details were entered into a database and appropriate queries and secondary screening were performed to identify candidates to several open trials. At subsequent clinic visits, patients were systematically approached by study coordinators and faculty physicians. The number of eligible candidates, number of patients enrolled and reasons for not enrolling were recorded. Results: The Navigator program was fully implemented in October 2003 and data through October 2004 are presented. A total of 373 patients were s.
(Z)-3-(2,4-Dichlorobenzyl)-1,5-benzothiazepin-4(5H)-one

In the title compound, C16H11Cl2NOS, the seven-membered thiazepine ring adopts a distorted twist-boat conformation. The dihedral angle between the mean plane of the benzothiazepine ring system and the benzene ring is 78.6 (1)°. The molecular conformation is stabilized by a weak intramolecular C—H⋯Cl hydrogen bond, which generates an S(5) ring motif. In the crystal, pairs of N—H⋯O hydrogen bonds link inversion-related molecules into dimers, generating R 2 2(8) ring motifs. The crystal packing also features alternating π–π interactions between benzothiazepine benzene rings [inter-centroid distance = 3.740 (3) Å] and dichlorobenzene rings [inter-centroid distance = 3.882 (3) Å] to consolidate a three-dimensional architecture.
Uso de tromboelastografía en cirugías de trasplante hepático y hepatectomías

Abreviaturas: CE = concentrado eritrocitario CID = coagulacion intravascular diseminada CP = crioprecipitados CF = concentrados fi brinogeno Fib = fi brinogeno FT = factor tisular HGM = Hospital General de Mexico PFC = plasma fresco congelado PL = plaquetas TEG = tromboelastografia TEP = tromboembolismo pulmonar TH = trasplante de higado TM = transfusion masiva TP = tiempo de protrombina TTPa = tiempo de tromboplastina activado TRALI = lesion pulmonar aguda producida por transfusion o transfusion related acute lung injury ROTEM = tromboelastometria rotatoria
Citicoline in the Treatment of Essential Tremor

Objectives: To evaluate the clinical efficacy of Citicoline for the treatment of patients affected by essential tremor. Methods: The study was conducted in the Neurology Department at King Hussein Medical Centre. A total of 18 subjects were non-randomly selected and enrolled in the study (8 males, 10 females), with a mean age of 62.6 years. The primary outcome measure was the degree of tremor compared to baseline as measured by the Clinical Rating Scale for Tremor. Results: The mean duration of symptoms among the study group was 6 years. All patients were evaluated at least twice, at enrollment and 8 weeks after starting treatment. The dose was 2ml twice daily (equivalent to 400mg /daily) taken orally. Seven subjects showed marked improvement on Clinical Rating Scale for Tremor. Seven subjects showed moderate improvements, and 2 subjects showed mild improvement, and two subjects showed no change. The overall improvement in all treated subjects was 89% (T-Value = 8.42, PValue = 0.000). The main side effects encountered during the treatment period were gastrointestinal symptoms in two subjects (11%), anxiety in one subject (6%), headache in one subject (6%), dizziness in one subject (6%), and insomnia in another (6%).
Targeting T-bet for Prevention of Graft-Versus-Host Disease and Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

viii Chapter 1: Background . 1 1.1 T-bet: a master regulator shaping immune responses . 1 1.1.1 T-bet in innate immunity . 1 1.1.2 T-bet in adaptive immunity . 3 1.1.3 T-bet in disease . 5 1.2 Allo-HSCT, GVHD, and GVL . 7 1.3 Helper T-cell differentiation: general pathways and characteristics . 10 1.3.1 The Th1/Th2 cell paradigm . 12 1.3.2 Differentiation and characteristics of Th17 cells . 13 1.3.3 Interaction of Th17 cells with Th1, Th2, and Tregs . 14 1.4 Helper T-cell subsets in GVHD: experimental and translational evaluations . 16 1.4. 1 Transcription factors involved in T-cell differentiation in GVHD . 16 1.4. 1.1 Th1: T-bet, STAT1, STAT4, c-Rel. 16 1.4. 1.2 Th17: RORγt, STAT3, AhR, and IRF4 . 19 1.4. 1.3 Tregs: Foxp3 . 20 1.4. 2 Effector cytokines of distinct T-cell subsets: contribution to GVHD. 21 1.4. 2.1 Th1: IFN-γ, TNF-α, and IL-2 . 21 1.4. 2.2 Th17: IL-17, TGF-β, IL-21, IL-23, and IL-6 . 23 1.4. 3 Reciprocal differentiation of Th1, Th2, and Th17 cells in GVHD . 26 1.5 Helper T-cell subsets in GVHD: clinical strategies . 27 1.5. 1 Current findings of the role of T-cell subsets in clinical GVHD . 27 1.5. 2 New approaches to target T-Cell differentiation for controlling GVHD in clinic . 28 1.6 Roles of CD8 T cells in GVHD development and mediating GVL effect . 33 ii 1.7 Effect of APCs in GVHD and GVL . 34 1.7. 1 APCs populations. 34 1.7. 1.1 Hematopoietic APCs . 34 1.7. 1.2 Nonhematopoietic APCs . 35 1.7. 2 Pathways of antigen presentation after allo-HSCT . 36 1.7. 3 Effect of APCs in GVHD . 36 1.7. 3.1 DCs in GVHD . 36 1.7. 3.2 B cells in GVHD . 37 1.7. 3.3 Macrophages in GVHD . 38 1.7. 3.4 Nonhematopoietic APCs in GVHD . 38 1.7. 4 Roles of APCs in mediating GVL effect . 39 1.7. 5 Strategies to targeting APCs in allo-HSCT . 39 Chapter 2: T-bet is Critical for the Development of Acute Graft-versus-Host Disease through Controlling T cell Differentiation and Function . 41 2.1 Abstract . 41 2.2 Introduction . 42 2.3 Materials and methods . 43 2.3.1 Mice . 43 2.3.2 BMT models . 44 2.3.3 Flow cytometry and serum cytokine detection . 45 2.3.4 Microarray and real-time PCR . 45 2.3. 5 In vitro generation of Th17 cells and Th17-mediated GVHD model . 47 2.3. 6 Statistics . 47 2.4 Results . 48 2.4. 1 T-bet is required for CD4 T-cell mediated acute GVHD . 48 2.4. 2 T-bet is important for GVHD induction in miHA-mismatched model. 50 2.4. 3 Differential gene profiles of T-bet and IFN-γ CD4 T cells after allo-BMT . 51 2.4. 4 T-bet regulates T-cell pathogenicity through IFN-γ-independent manners . 53 2.4. 5 T-bet controls the optimal function of Th17 cells in GVHD induction . 56 2.4. 6 T-bet donor T cells largely preserve the GVL effect by neutralizing IL-17 in allo-BMT recipients . 60 2.5 Discussion . 63
Original Contribution VANCOMYCIN-RESISTANT ENTEROCOCCI IN HOSPITALIZED PATIENTS WITH URINARY TRACT INFECTIONS - FIRST REPORT IN BULGARIA

Vancomycin-resistant enterococci (VRE) present a serious problem in a hospital setting because they reduce treatment options in enterococcal infections. Using the conventional tests and the Sceptor MIC/ID System (BBL), we analysed 2 VRE strains isolated from the urine of patients at the University Hospital in Stara Zagora, Bulgaria. In vitro susceptibility testing was done using the DDM (Bayer – Kirby) and MIC (Agar Dilution Method; E-test). Resistance to high-level aminoglycosides (HLAR) was determined by DDM using disk containing Gentamicin 120 µg. The E. faecalis isolates were a strain with multiresistance to high-level aminoglycosides, beta-lactams, fluoroquinolones, and Vancomycin but susceptible to Teicoplanin. E. faecium, the second urine isolate, was equally multiresistant to high-level aminoglycosides, beta-lactams, fluoroquinolones, and Vancomycin but susceptible to Teicoplanin. The problem of VRE in Bulgaria already exists. It is imperative to monitor the enterococcal infections in the hospitals now, when they are still sporadic.
Mr 92,000 Type IV Collagenase Is Increased in Plasma of Patients with Colon Cancer and Breast Cancer

Overproduction of matrix metalloproteinases (MMPs) is a common characteristic of metastatic cancer cells. Since MMPs can be identified in plasma, we proposed that enhanced MMP-9 secretion by invasive cancer cells may be detected by plasma assay. To this end, we developed a specific sandwich enzyme-linked immunosorbent assay which uses two mouse monoclonal antibodies to human M r 92,000 type IV collagenase (MMP-9). The plasma concentration of MMP-9 (mean ± SD) in 60 healthy subjects (9 ± 11 ng/ml), 136 patients without cancer, and 179 patients with cancer of the lung, genitourinary tract, or lymphomas-leukemias did not differ significantly. In contrast, plasma MMP-9 was significantly increased ( P < 0.01) in 122 patients with gastrointestinal tract cancer and breast cancer (18 ± 23 and 21 ± 22 ng/ml, respectively). Whereas carcinoembryonic antigen levels were significantly increased in patients with stage IV gastrointestinal cancer, MMP-9 concentrations were not significantly increased in patients with metastatic disease as compared to those with nonmetastatic cancer. Combining both assays improves sensitivity of detection of colon cancer. MMP-9 was also significantly increased during pregnancy which is consistent with the extensive ongoing tissue remodeling and the leaching of the tissue proteinase into plasma.
Combining Self Organizing Maps and Multilayer Perceptrons to Learn Bot-Behavior for a Commercial Computer Game

Traditionally, the programming of bot behaviors for commercial computer games applies rule-based approaches. But even complex or fuzzyfied automatons cannot really challenge experienced players. This contribution examines whether bot programming can be treated as a pattern recognition problem and whether behaviors can be learned from recorded games. First, we sketch a technical computing interface to a commercial game that allows rapid prototyping of classifiers for bot programming. Then we discuss the use of self organizing maps to represent manifolds of high dimensional game data and how multilayer perceptrons can model local characteristics of such manifolds. Finally, some experiments in elementary behavior learning are presented.
INCREDIBLE THERAPEUTIC BENEFITS OF GLYCIRRHIZA GLABRA

lycyrrhiza glabra has been used in medicine for more than 4000 years. The earliest record of its use in medicine is found in 'code Hammurabi' (2100 BC). It was also one of the important plants mentioned in Assyrian herbal (2000BC). Hippocrates (400BC) mentioned its use as a remedy of ulcers and quenching of thirst. Theophrastos of Lesbos, writing in the fourth century BC wrote that 'It has the property of quenching thirst if one holds it in the mouth'. Dioscorides gave the plant its botanical name (Greek glukos = sweet, riza = root). Its 13th century English name was Lycorys, a corruption of glycyrrhiza. Liquorice (Glycyrrhiza glabra) has long been used for both culinary and medical purposes. It is widely used in bronchial problems such as catarrh, bronchitis, cold, flu and coughs. It reduces irritation of the throat and yet has an expectorant action. It produces its demulcent and expectorant effects. It is used in relieving stress. It is a potent healing agent for tuberculosis, where its effects have been compared to hydrocortisone. Glycyrrhiza is also effective in helping to reduce fevers (glycyrretinic acid has an effect like aspirin), and it may have an antibacterial action as well. Its use in the treatment of chronic inflammations such as arthritis and rheumatic diseases, Anti- inflammatory, chronic skin conditions, and autoimmune diseases in general.
ACCF/SCAI/SVMB/SIR/ASITN 2007 Clinical Expert Consensus Document on Carotid Stenting

2007;49;126-170 J. Am. Coll. Cardiol. H. Stein, Cynthia M. Tracy, Robert A. Vogel, and Deborah J. Wesley Lindner, Gerald M. Pohost, Richard S. Schofield, Samuel J. Shubrooks, JR, James Eisenberg, Cindy L. Grines, Mark A. Hlatky, Robert C. Lichtenberg, Jonathan R. Harrington, Jonathan Abrams, Jeffrey L. Anderson, Eric R. Bates, Mark J. Rundback, Robert D. Safian, Michael A. Sloan, Christopher J. White, Robert A. William A. Gray, Kenneth Ouriel, Eric D. Peterson, Kenneth Rosenfield, John H. Donald E. Casey, Jr, Christopher U. Cates, Gary R. Duckwiler, Ted E. Feldman, Biology, Society of Interventional Radiology, Eric R. Bates, Joseph D. Babb, Cardiovascular Angiography and Interventions, Society for Vascular Medicine and American Society of Interventional & Therapeutic Neuroradiology, Society for Committee on Carotid Stenting) (ACCF/SCAI/SVMB/SIR/ASITN Clinical Expert Consensus Document Task Force on Clinical Expert Consensus Documents Carotid Stenting: A Report of the American College of Cardiology Foundation ACCF/SCAI/SVMB/SIR/ASITN 2007 Clinical Expert Consensus Document on This information is current as of January 4, 2011 http://content.onlinejacc. org/cgi/content/full/49/1/126 located on the World Wide Web at: The online version of this article, along with updated information and services, is
(2E)-1-(2,6-Dichloro-3-fluorophenyl)-3-phenylprop-2-en-1-one

In the title compound, C15H9Cl2FO, the F atom shows positional disorder over two positions, with site-occupancy factors of 0.747 (4) and 0.253 (4). The dihedral angle between the rings is 86.37 (10)°. In the crystal, C—H⋯O contacts connect the molecules into chains along the c axis. The shortest inter-centroid distance between two aromatic systems is 3.6686 (12) Å and is apparent between the halogenated rings.
1′-Methyl-3′-(4-methylbenzoyl)-4′-[5-(2-thienyl)-2-thienyl]spiro[acenaphthylene-1,2′-pyrrolidin]-2(1H)-one

In the title compound, C32H25NO2S2, the mean plane through the five-membered pyrrolidine ring, which exhibits an envelope conformation, makes dihedral angles of 82.3 (1) and 83.9 (9)° with the benzene ring and the acenaphthylene ring system, respectively. The dihedral angle between the thiophene rings is 19.0(3)°. The crystal structure shows C—H⋯π and π–π interactions [centroid–centroid distance = 3.869 (2) Å].
2-Acetyl-3,5,5,9-tetramethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-one

The title compound, C17H22O2, was semi-synthesized from a mixture of α-atlantone (Z) and α-atlantone (E), which were isolated from the essential oil of the Atlas cedar (cedrus atlantica). The molecule consists of fused six- and seven-membered rings. The seven-membered ring is in a screw-boat conformation.
Transmisión de Agregatibacter actimomycetemcomitans en Familias con Periodontitis Crónica: Una Revisión de Literatura Transmission of Agregatibacter actimomycetemcomitans in families with chronic periodontitis: A literature review

SUMMARYThis literature review cross-contaminationevidence of periodontal pathogens, specificallyAggregatibacter actinomycetemcomitansbetween members of the same family,which includes spouses and children, aswell as to identify the more importanttransmission routes. Describing the possibleroutes of transmission of periodontalbacteria could lead to methods to preventor reduce microbial cross-contaminationbetween family members and possiblyreduce disease transmission.Key words: Periodontitis, microbiology,transmission, Aggregatibacter actinomycetemcomitans.
Phase III trial of nilotinib versus imatinib as first-line targeted therapy of advanced gastrointestinal stromal tumors (GIST).

10501^ Background: Nilotinib (N) is a Bcr-Abl, KIT, and PDGFR tyrosine kinase inhibitor. This Phase III trial compared N and imatinib (I) as first-line therapy of advanced GIST. Accrual was stopped when a futility boundary was crossed at interim analysis (IA). This final analysis of the core study examined the effect of mutation on outcomes. Methods: Patients (pts) with unresectable and/or metastatic GIST who had no prior antineoplastic therapy or had recurrence ≥6 months (mos) after adjuvant I were randomized 1:1 to open-label N 400 mg bid or I 400 mg qd (400 mg bid for KIT exon 9 mutants). The primary endpoint was progression-free survival (PFS) per adjudicated central review. Enrollment targeted 736 pts to observe 375 events, yielding 90% power to detect a hazard ratio (HR) of 0.71 (median, 28 [N] and 20 [I] mos) with two-sided 5% type I error. Prior to IA, crossover was allowed only for pts with progressive disease (PD); after IA, pts on N with or without PD were offered I. Results: At IA, the PFS HR .
Management of Acute Rhinosinusitis, Bronchitis Syndromes, and Acute Otitis Media

PURPOSE: The most common community-acquired acute respiratory illnesses (ARIs) are acute rhinosinusitis, acute bronchitis/acute exacerbation of chronic bronchitis in adults, and acute otitis media in children. This review focuses on the judicious use of empiric antimicrobial therapy for the treatment of these syndromes. EPIDEMIOLOGY: ARIs affect 30 million patients in the United States and cost approximately US$1.3 billion annually. They are the most common indications for prescription of antimicrobial agents. REVIEW SUMMARY: Identifying patients who have bacterial ARIs is essential to curbing inappropriate antimicrobial use and related escalation in costs. The most common bacterial causes of ARIs include Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Approximately 25% of S pneumoniae are resistant to penicillins and macrolides, wh ereas one third of H influenzae and nearly 100% of M catarrhalis produce β-lactamases. Because 15% to 75% of patients with bacterial ARIs may recover spontaneously, antimicrobials should be used as per published guidelines. Finally, minimizing/eliminating exposure to risk factors for ARIs (eg, smoking, allergens) and emphasizing protective practices such as breast-feeding in infancy are essential as preventive measures. TYPE OF AVAILABLE EVIDENCE: Systematic reviews/meta-analyses, randomized-controlled trials, controlled prospective and retrospective cohort studies, and unstructured reviews. GRADE OF AVAILABLE EVIDENCE: Good. CONCLUSION: ARIs are a significant cause of morbidity and contribute significantly to US health costs. The diagnosis of ARIs is mainly clinical and treatment remains largely empiric; awareness in addition to practice of published guidelines for diagnosis and treatment of these syndromes is crucial. Antimicrobial therapy should be used selectively and preventive measures considered whenever feasible. (Adv Stud Med. 2005;5(7):344-350)
Grado en Óptica y Optometría

Goal: The main objective of this work is to reach a consensus for the follow-up and treatment of ocular hypertensive patients and to consider the role of the optometrist in the management of these patients. Methods: A literature review of protocols for monitoring these types of patients will be done; therefore the consensus will be based on the criteria of the main scientific societies. Results: In this protocol for the follow-up of a patient with ocular hypertension we have mainly adopted the NICE recommendations, which set out a series of tests and treatment guidelines to be performed on all patients with OHT, POAG or suspected POAG. Conclusions: In conclusion, to manage ocular hypertensive patient we should follow NICE guidelines, doing a series of tests routine for all patients with OHT or suspected POAG. The healthcare professionals who treat these patients should be aware of treatment options, evaluating the need to start or not a therapy, and if so, determine the patterns of management and monitoring of it.