Miracle-dz/UniFAR-FTUs huggingface dataset:
IN VITRO ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACTS FROM SOME LAVANDULA SPECIES CULTIVATED IN ROMANIA

The antioxidant activity of five samples of Lavandulae flowers (L. angustifolia ssp. angustifolia, L. hybrida, L. angustifolia spp. pyrenaica, L. angustifolia spp. angustifolia cv. Munstead and cv. Hidicote Blue) harvested from Romania was investigated using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging and ferrous ion chelating assays. Total polyphenolic content (mg/g dried extract) was also determined. In both antioxidant assays, all lavender extracts showed significant and concentration-dependent activities. The ferrous ion chelating effect was superior to DPPH radical scavenging effect. Ethanolic extract from Lavandula hybrida was found to be the most active (IC 50 = 73.53 ∝g/mL in DPPH scavenging assay and IC 50 =49.90 ∝g/mL in ferrous ion chelating assay). Except Lavandula hybrida and Lavandula angustifolia cv. Munstead, there is no strict positive relationship between the polyphenolic content and antioxidant activity of extracts. Rezumat Extracte etanolice din cinci specii de Lavandula (L. angustifolia ssp. angustifolia, L. hybrida, L. angustifolia spp. pyrenaica, L. angustifolia spp. angustifolia varietatile Munstead și Hidicote Blue) cultivate in Romania au fost investigate in ceea ce privește activitatea antioxidantă și conținutul in polifenoli totali. Au fost utilizate testul de scavenger de radicali DPPH (2,2-difenil-1-picrilhidrazil) și cel de chelatare a ionilor Fe 2+ . Toate extractele de lavandă prezintă o activitate antioxidantă importantă și dependentă de concentrație. Acțiunea de chelatare a ionului feros este superioară celei de scavenger de radicali DPPH. Cea mai activă specie este Lavandula hybrida (CI 50 = 73.53 ∝g/mL și respectiv, CI 50 =49.90 ∝g/mL). Cu excepția extractelor de Lavandula hybrida și Lavandula angustifolia varietatea Munstead, nu există o corelație strict pozitivă intre conținutul in polifenoli și proprietățile antioxidante ale extractelor de lavandă.
Gastroparesis in diabetes mellitus: an ultrasonographic study.

BACKGROUND AND AIM To investigate diabetic gastro-paresis, a complication of diabetes mellitus and its determinants. MATERIAL AND METHODS A group of 36 patients with diabetes and 20 healthy controls, with comparable age and sex ratio were investigated with an established ultrasonographic method. A mixed test meal of 400 kcal was given. Antral fasting and postprandial area, postprandial distension and emptying time were assessed. Glucose control was estimated by the measurement of fasting and postprandial glucose as well as by assessing HbA1c. RESULTS Antral area was nonsignificantly larger in diabetes mellitus. Postprandial antral area and postprandial antral distension were higher in diabetes than in the controls. The prevalence of gastroparesis was 52.7%, without differences between the two types of diabetes: 53.8% in type I and 52.2% in type II diabetes mellitus. Gastroparesis was associated with poor short and long time control of blood glucose and with positive parasympathetic tests. Gastroparesis did not correlate with symptoms. CONCLUSION Gastroparesis is a real complication in diabetes mellitus and can be documented using an ultrasonographic method. Poor glucose control and autonomic neuropathy are associated with gastroparesis.
HIV Prevention Needs of Sex-Trading Injection Drug-Using Black Men Who Have Sex With Both Men and Women

This study examined HIV prevention program needs from the perspective of injection drug—using men who have sex with both men and women involved in sex trade. Focus groups were conducted involving an exploratory sample (N = 105) of men who met the following parameters: African American, injection drug—using behavior, men who have sex with men and women, and men who frequent parks and other areas for sex trade in Baltimore City and surrounding areas, aged between 18 and 40 years. Data suggest that an HIV prevention program is needed that includes a safe space specifically for the IDU-MSM/W sex-trade community, comprehensive services including treatment for substance abuse and job assistance, and methods for improving HIV-prevention, such as communication skills to increase condom use during sex. These findings provide a better understanding of a population for which little is known, and identifies HIV prevention program needs for the IDU-MSM/W community involved in sex trade.
An introduction to network address shuffling

Moving Target Defense (MTD) has been proposed as a new revolutionary technology to alter the asymmetric situation between attacks and defences. Network address shuffling is an important branch of MTD technology. However, there is no systematic introduction to network address shuffling. In this paper, we present a brief introduction to the research achievements of network address shuffling according to two shuffling patterns which are identified and defined by us. We then summarize and analyze the supporting techniques and related features for each network address shuffling technique mentioned in this paper. What's more, the key issues to implement an effective network address shuffling mechanism are discussed, with the expectation of invigorating subsequent research.
A unified 7.5nm dash-type confined cell for high performance PRAM device

We present a new-type confine structure within 7.5 nm width dash-contact for sub 20 nm generation PRAMs. Phase change material (PCM) by chemical vapor deposition (CVD) was perfectly filled in a 7.5 nm width dash-contact without void along with 30 nm depth. By adopting confined CVD-PCM, we were able to reduce the reset current below ~160 muA and to obtain high reliability. In addition, the programming time of dash-confined cell was much improved to 50 ns due to volume confinement of PCM cell. Consequently, we firstly demonstrate the high performance of the 7.5 nm width confined cell, which is the smallest size close to physical limit.
An Efficient Approach to Detect Concept Drifts in Data Streams

Due to the presence of data streams in many applications like banking, sensor networks, and telecommunication, data stream mining has gained increased attention. Data stream is continuous, ordered sequence of data instances arriving at a rapid rate. One of the key challenges while learning from data streams is the detection of concept drift, i.e., changes in data distribution underlying data streams, observed over time. Drifts being either gradual or sudden, several algorithms have been put forward for detection of different kinds of drift. However, most of them work on only one of these kinds of drift. These algorithms show hampered output if different types of drift are mixed. To solve this issue, there is need of a single system that can handle all drifts simultaneously. In this paper, we propose a system that detects both kinds of drift efficiently. Our system combines features of the online classifier as well as a blockbased classifier to achieve the goal. We further analyzed drifts to find out missing values of attributes to be the root cause. Our system handles missing values in different ways for more improved performance.
OLIG‐1 and 2 gene expression and oligodendroglial tumours

OLIG 1/2 genes encode basic helix‐loop‐helix transcription factors that play a critical role in motor neurone and oligodendrocyte fate specification during development. Two recent studies in which OLIG transcripts were detected by in situ hybridization have reported a high expression of the OLIG genes in oligodendrogliomas. This suggests that the detection of these lineage markers could become an adjunct to the classic morphological diagnosis of these tumours. There are problems in the diagnosis of oligodendroglioma. To date, all other known oligodendrocyte lineage markers have failed to label specifically neoplastic oligodendrocytes. Deletions on chromosome 1p and 19q are much more frequent in oligodendrogliomas than in astrocytomas but these molecular alterations are not constant. For the future, when routinely available, immunohistochemical techniques using anti‐OLIG antibodies on paraffin embedded tissues will allow a systematic study of a large series of tumours so that we will know the specificity and sensitivity of this investigation in diagnosis.
Changing typology of brain death liver donors: characteristics and impact of risk factors on short-term outcome.

BACKGROUND/AIMS An effective recruitment plan and the use of donors with risk factors are essential means of compensating for the lack of organs, but mean a significant change in the type of donor. This study defines the characteristics of the donors currently used, evaluates their impact on short-term outcome and underlines the need for a different approach to organ selection. METHODOLOGY Data concerning 244 patients were collected for the study of donor characteristics by age groups, and the multivariate analysis of the associated risk factors. RESULTS There were no significant differences other than the cause of donor death and the appearance of the organ. The annual percentage of donors aged more than 60 years has increased from 5.2% to 47.6%; the percentage of organs from over-60-year-old donors discarded after bioptic sampling was 25.6% (10.4% for donors aged < 60 years). Perioperative mortality did not significantly differ on the basis of donor age (p = 0.186). CONCLUSIONS Today's liver donors are mainly subjects who have died of cerebrovascular disease, often at an age of > 60 years, and are also affected by other diseases or metabolic alterations. They require a different method of evaluation and, in those aged more than 60 years, the routine use of histological examinations in organ selection. Furthermore, the judicious extension of the inclusion criteria and the characteristics of the currently available donors do not seem to affect short-term, post-transplant outcome.
Lack of Association of Multidrug Resistance Gene-1 Polymorphisms with Treatment Outcome in Chronic Myeloid Leukemia Patients Treated with Imatinib

Background: Despite the impressive results obtained with imatinib, inadequate response or resistance are observed in certain patients. It is known that imatinib is a substrate of a multidrug resistance gene ( MDR1 ). Thus, interindividual genetic differences linked to single nucleotide polymorphisms in MDR1 may influence the metabolism of imatinib. The present study has aimed to examine the impact of MDR1 polymorphisms on the hematologic and cytogenetic responses in 70 chronic myeloid leukemia patients who received imatinib. Methods: We used a polymerase chain reaction followed by restriction fragment length polymorphism to identify different profiles of 1236C>T, 2677G>T and 3435C>T in MDR1 . Results: The distribution of the three SNPs in responders and poor responders did not show any particular trend (P>0.05). The T allele was slightly higher in responders, but not significantly regardless of the type of SNP (40.3% vs. 33.8% for 1236C>T; 25% vs. 14.7% for 2677G>T and 33.3% vs. 22% for 3435C>T). The dominant model showed a similar trend (P>0.05). Diplotypes composed by the T allele in different exons were frequent in responders. Haplotype analysis showed that 1236C-2677G-3435C was slightly higher in poor responders (60.02%) compared to responders (50.42%). However, 1236T-2677T-3435T was frequent in responders (16.98%) compared to poor responders (13.1%). Overall, none of the haplotypes were associated with IM response in our cohort (global haplotype association test, P=0.39). Conclusion: The identification of 1236C>T, 2677G>T and 3435C>T polymorphisms may not be advantageous to predict imatinib response for our chronic myeloid leukemia patients.
NUT Midline Carcinoma: Morphoproteomic Characterization with Genomic and Therapeutic Correlates.

NUT midline carcinoma is a rare entity arising primarily in the midline of teenagers and young adults. Genomically, it is associated with a translocation involving a nuclear protein in testis (NUT) gene with other genes, most commonly, the BRD4 gene. The resultant is a partial or near total block in differentiation of tumor cells into mature squamous elements. Such tumors are resistant to conventional therapy with a reported mean survival at less than 1 year. In this study, we investigated two cases with genomic confirmation as NUT midline carcinoma by morphoproteomic analysis using immunohistochemical antibodies. Our results showed overexpression, largely in the undifferentiated cells of the tumors of: 1) Stemness marker, SRY (sex determining region Y)-box 2 (Sox2); 2) Constitutive activation of the mTORC2 pathway with expression of total insulin-like growth factor-1 receptor (IGF-1R[Tyr1165/1166]), and nuclear p-mTOR (Ser 2448) and p-Akt (Ser 473); and 3) c-Myc, silent mating type information regulation 2 homolog 1 (Sirt1) and histone methyltransferase enhancer of Zeste, Drosophila, homolog 2 (EZH2) as molecular impediments to differentiation. These data were analyzed through the use of QIAGEN's Ingenuity(®) Pathway Analysis (IPA(®), QIAGEN Redwood City, www.qiagen. com/ingenuity). The results established the interconnection of these pathways and molecules, and identified several pharmacogenomic agents--melatonin, metformin, vorinostat, curcumin, and sulforaphane--that have the potential to remove the block in differentiation and lead to the establishment of a more benign form of NUT midline carcinoma.
A compact threshold voltage model for gate misalignment effect of DG FD SOI nMOS devices considering fringing electric field effects

This paper reports an analysis of gate misalignment effect on the threshold voltage of double-gate ultrathin fully depleted silicon-on-insulator nMOS devices using a compact model considering the fringing electric field effect, biased at zero-bias V/sub DS/. Using the conformal mapping transformation approach, a closed-form compact model considering the fringing electric field effect in the nongate overlap region has been derived to provide an accurate prediction of the threshold voltage behavior as verified by the two-dimensional simulation results.
The hepatitis C virus and its relationship to the clinical spectrum of NANB hepatitis

This quadrennial review on non-A, non-B (NANB) hepatitis is being written at a propitious time since knowledge of this disease has expanded exponentially in the past year following the cloning of the primary causative agent, now designated the hepatitis C virus (HCV). For the first time, the nature of this virus is known, including its basic genomic organization and its tentative taxonomic link to the arthropod-borne flaviand pestiviruses. In addition, the development of a serologic assay to detect antibody to HCV (anti-HCV) has allowed for seroepidemiologic surveys and new insights into the NANB hepatitis disease spectrum. This report will briefly review what was known about NANB hepatitis and its causative agent prior to the cloning of HCV and will integrate this with recent discoveries relating the virology, molecular biology and serology of this agent and their relationship to clinical disease, transmission patterns, treatment and prevention.
A case of diploid/triploid mosaicism with dental Blaschko lines.

Introduction Diploid/triplod mosaicism is a rare, but well-known malformation syndrome. In about 75% of cases, the chromosomal analysis in peripheral blood is normal and the diagnosis needs to be established by tissue sampling, usually on cultured fibroblasts from a skin biopsy; recently, easier and less invasive methods have been applied, using interphase fluorescence in-situ hybridization and microarray-based comparative genomic hybridization (Cheung et al., 2007; Locatelli et al., 2005). About half of the patients with diploid/triploid mosaicism present with mental retardation, growth retardation, truncal obesity, body and/or facial asymmetry, hypotonia, cutaneous syndactyly and clinodactyly of fingers and toes and malformed low-set ears (Van de Laar et al., 2002).
Laser Spectroscopy and Magneto-Optical Trapping of Rubidium Atoms

of the Thesis Laser Spectroscopy and Magneto-Optical Trapping of Rubidium Atoms by David E. Sproles Master of Scientific Instrumentation in Physics Stony Brook University 2008 This thesis describes experiments on laser spectroscopy and magnetooptical trapping of Rb atoms. We perform polarization spectroscopy with a novel high-power diode laser system. An ultrahigh vacuum apparatus in the 10−10 Torr regime has been built which allows trapping of ultracold clouds of rubidium atoms. These atoms can be moved in a mechanically translated magnetic trap from the trapping region into the lower pressure region of the system with minimal losses. We demonstrate magento-optical trapping of ultracold atoms, with atom numbers up to 10 atoms and temperatures below 1mK, as observed by fluorescence imaging.
A Comparative Study Using Discriminant Analysis on a Questionnaire Survey Regarding Project Managers’ Cognition and Team Characteristics

The purpose of this study is to create a model of a relationship in which the dependent variable is the result of a project and the independent variables are the characteristics of human resources. We attempted a comparative evaluation of discriminant analyses with a statistical model and a machine learning model using assessments of the results of projects and team characteristics derived from questionnaire survey data. The results of the evaluation demonstrate that the machine learning model shows a higher discrimination rate within the range of the data used in the analysis, but it became clear that the discrimination rate worsens in comparison with the statistical model when extrapolated.
Impact of cytogenetic abnormalities on the management of skull base chordomas.

OBJECT Cytogenetic studies of chordomas are scarce and show multiple changes involving different chromosomes. These abnormalities are implicated in the pathogenesis of chordoma, but the clinical significance of these changes is yet to be determined. In this study, the authors discuss the cytogenetic changes in a large series of skull base chordomas with long-term follow-up and focus on the impact of these changes on the prognosis, progression, and management of the disease. METHODS The karyotypes of chordomas in 64 patients (36 men and 28 women) were studied in relation to survival and recurrence or progression over a mean follow-up period of 48 +/- 37.5 months. The standard G-banding technique was used for karyotype analysis. Statistical analysis was performed with the Fisher exact test and ORs, and Kaplan-Meier curves were generated for survival and recurrence/progression of disease. RESULTS Seventy-four percent of de novo chordomas had normal karyotypes and a 3% recurrence rate; there was a 45% recurrence rate in de novo tumors with abnormal karyotypes (p < 0.01). Recurrent tumors were associated with a high incidence of abnormal karyotype (75%). The OR for recurrence in lesions with an abnormal versus a normal karyotype was 12. Aberrations in chromosomes 3, 4, 12, 13, and 14 were associated with frequent recurrence and decreased survival time. Ninety-five percent of cases with progression involved chromosome 3 and/or 13. The median survival time was 4 months when both of these chromosomes had aberrations (p = 0.02). CONCLUSIONS Chordomas with normal karyotypes were associated with a low rate of recurrence and a long patient survival, and recurrent chordomas were associated with an abnormal karyotype, disease progression, and poor survival. De novo chordomas with normal karyotypes may be amenable to radical resection and adjunctive proton beam therapy. Recurrent and de novo chordomas with abnormal karyotypes were associated with complex cytogenetic abnormalities and a poor prognosis, particularly in the presence of aberrations underlying tumor progression in chromosomes 3, 4, 12, 13, and 14.
Acute reversible cerebellar lesions associated with metronidazole therapy

A 27-year-old man with acute lymphoblastic leukemia developed ataxia, dysarthria, and confusion 2 weeks after initiating metronidazole therapy for Clostridium difficile colitis. Brain MRI revealed cytotoxic edema, without contrast enhancement, in the cerebellar dentate nuclei (figure, A and B), dorsal pons, and medulla. Metronidazole …
Cardiovascular Responses to Somatosensory Stimulation and Their Modulation by Baroreflex Mechanisms

Exposure of experimental animals to noxious somatic stimulations sometimes induces sustained hypertension. Information regarding the medullary projections of somatic afferents and the neurotransmitters involved in them is incomplete. The present investigation in urethane-anesthetized, artificially ventilated, adult male Wistar rats was undertaken to clarify some of these issues. It was observed that the inhibition of contralateral, ipsilateral, or bilateral rostral ventrolateral medullary pressor area (RVLM) with muscimol attenuated the pressor and tachycardic responses to sciatic nerve stimulation. Similar inhibition of the medial subnucleus of the solitary tract (mNTS) exaggerated the cardiovascular responses to sciatic nerve stimulation. Interruption of the baroreflex by microinjections of ionotropic glutamate receptor antagonists into the mNTS or barodenervation also exaggerated the responses to sciatic nerve stimulation. Unilateral stimulation of the aortic nerve blocked the cardiovascular responses to the sciatic nerve stimulation. These results indicated that in the rat, the ascending afferents in the sciatic nerve project bilaterally to the RVLM as well as mNTS; an excitatory amino acid, probably glutamate, is released in the mNTS in response to the sciatic nerve stimulation; and barodenervation or blockade of baroreflex in the mNTS exaggerates, while baroreceptor stimulation inhibits, cardiovascular responses to somatosensory stimulation.
Drugs and recovery: a challenge for a few?

To the Editor: I read with great interest the recent article by Walker-Batson and colleagues,1 in which the authors show that the administration of dextroamphetamine and speech/language therapy facilitated recovery from aphasia. We also investigated the efficacy of high-dose bromocriptine, prescribed according to a dose-escalating protocol, combined with speech therapy in a double-blind study.2 Patients showed a significant improvement in language (verbal latency, repetition, reading comprehension, dictation, and free speech) during treatment, yet we considered the study negative. The high frequency of contraindication to bromocriptine administration in the enrollment phase (44% of the aphasic patients) allowed us to treat only a small sample of patients. Moreover, we observed an elevated occurrence of side effects during the active phase of the drug. Remarkably, none of the patients enrolled into the study of Walker-Batson et al had …
Coronary Arteries in Physiological Hypertrophy: Echocardiographic Evidence of Increased Proximal Size in Elite Athletes

One hundred and twenty-five healthy, male top-level athletes were evaluated by echocardiography (Echo) and assigned to six groups according to the size of the left ventricular mass (L. V. Mass), calculated according to Devereux R. B. et al.: less than or equal to 200, 201-250, 251-300, 301-350, 351-400, or greater than 400 g. Echo evaluation of coronary artery (c.a.) proximal size was performed following the method described by Kalavathy et al. (J Am Coll cardiol 1986, 8, 1119-1124). Two of us separately conducted the measurement of the c.a. diameter at congruent to 1 cm from the respective aortic ostium on M-Mode tracings and 2-D end-diastolic frames. The inter-observer variability was lower for the M-Mode (4.2%) than 2D (9.3%) measurements: the correlation between A and B observers equals r = 0.867 for the right c.a. , and r = 0.859 for the left main c.a.