Miracle-dz/UniFAR-FTUs huggingface dataset:
Chrono‐nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns

The circadian timing system governs daily biological rhythms, synchronising physiology and behaviour to the temporal world. External time cues, including the light‐dark cycle and timing of food intake, provide daily signals for entrainment of the central, master circadian clock in the hypothalamic suprachiasmatic nuclei (SCN), and of metabolic rhythms in peripheral tissues, respectively. Chrono‐nutrition is an emerging field building on the relationship between temporal eating patterns, circadian rhythms, and metabolic health. Evidence from both animal and human research demonstrates adverse metabolic consequences of circadian disruption. Conversely, a growing body of evidence indicates that aligning food intake to periods of the day when circadian rhythms in metabolic processes are optimised for nutrition may be effective for improving metabolic health. Circadian rhythms in glucose and lipid homeostasis, insulin responsiveness and sensitivity, energy expenditure, and postprandial metabolism, may favour eating patterns characterised by earlier temporal distribution of energy. This review details the molecular basis for metabolic clocks, the regulation of feeding behaviour, and the evidence for meal timing as an entraining signal for the circadian system in animal models. The epidemiology of temporal eating patterns in humans is examined, together with evidence from human intervention studies investigating the metabolic effects of morning compared to evening energy intake, and emerging chrono‐nutrition interventions such as time‐restricted feeding. Chrono‐nutrition may have therapeutic application for individuals with and at‐risk of metabolic disease and convey health benefits within the general population.
ZMILE, a multicomponent self-management intervention for adults with epilepsy: Rationale and description of the intervention

Objective: In this paper, we aim to provide a comprehensive description of the multicomponent self-management intervention for adults with epilepsy, ZMILE. Rationale or theory: Acquiring self-management skills has been shown to play a vital role in enabling patients with epilepsy overcoming (health-related) struggles in daily life and coping with limitations their condition poses on them. ZMILE is a course consisting of education (to increase concordance to treatment), goal-setting (proactive coping), and self-monitoring. Resources needed: The course is guided by two nurse practitioners and each patient is allowed to bring one family member or friend. Self-monitoring plays an important role and can be done through e-Health tools or written diaries. Processes involved: During and after the course, patients are required to work toward a personally defined goal using a five-step approach by means of pro-active coping. Moreover, patients are expected to use self-monitoring tools to reflect on their own behavior and identify ways to optimize medication intake when required. Quantification: ZMILE is provided in an outpatient setting over five weekly group sessions and one booster session. From the start, patients are encouraged to set individual goals. Each group session will have a different theme but part of every session is reflecting on personal goals and to learn from eachother. Conclusions: The ZMILE-intervention has been evaluated and may be a promising intervention in terms of effectiveness and feasibility for adults with epilepsy, relatives, and professionals. We present the adapted version which can be implemented in clinical practice.
Pseudomonas aeruginosa injection decreases drainage in lateral neck dissection for metastatic thyroid cancer.

Background Pseudomonas aeruginosa injection (PAI) has been proven effective against chylous fistula but not in decreasing drainage after lateral neck dissection (LND). To verify the safety of spraying PAI onto the surface of the traumatic cavity after total thyroidectomy with LND and to evaluate whether its application can reduce the drainage volume. Methods A total of 85 patients with metastatic papillary thyroid cancer (PTC) who agreed to total thyroidectomy with unilateral LND were recruited from March 2016 to September 2017. During the operation, PAI was applied in 44 patients, while 41 remaining patients served as the control group. The thyroid function and parathyroid function, drainage volume, hospital stay, and incidence of complications were compared between the two groups. Results The groups had few differences in age, gender, BMI, thyroid function, parathyroid function, diameter of tumor, and the number of the harvested lymph nodes. The median total drainage volume was significantly smaller and the mean hospital stay was obviously shorter in the PAI group compared to the non-PAI group. But the median volumes of peak 24-hour drainage which appeared during the first day after operation had few differences in the two groups. Postoperative fever in the PAI group was higher than in the non-PAI group. None of the patients had permanent recurrent laryngeal nerve paralysis and tumor recurrence on the 12th month after operation. Conclusions The application of PAI to the wound cavity after LND is safe and effective for reducing the drainage volume and hospital stay.
Shifts towards overweight and double burden of malnutrition among socio-economically vulnerable children: a longitudinal ecological analysis of Brazilian municipalities

Abstract Objective: To investigate the shifts and factors associated with different scenarios resulting from the prevalence of child stunting and overweight in Brazilian municipalities. Design: This is an ecological study using municipality-level panel data of stunting and overweight prevalence and socio-economic characteristics from 2008 to 2014. The municipalities were classified according to the WHO-UNICEF prevalence thresholds for stunting and overweight and were categorised into four nutritional scenarios: no burden (prevalence of stunting < 20 % and overweight < 10 %), stunting burden (prevalence of stunting ≥ 20 % and overweight < 10 %), overweight burden (prevalence of stunting < 20 % and overweight ≥ 10 %) and double burden (prevalence of stunting ≥ 20 % and overweight ≥ 10 %). Setting: Totally, 4443 Brazilian municipalities. Participants: Aggregated data of children under 5 years old enrolled in the Brazil’s conditional cash transfer programme (Bolsa Família). Results: A mean reduction from 14·2 % to 12·7 % in the prevalence of stunting and an increase from 17·2 % to 18·4 % in the prevalence of overweight were observed. The predominant scenarios were overweight burden and double burden. The odds of both scenarios increased with higher gross domestic product (GDP) per capita and decreased with higher unemployment rates. Stunting and double burden decreased with higher expected years of schooling, and stunting burden increased with household crowding. Conclusion: Our findings indicate an advanced nutrition transition stage in Brazil, associated mainly with municipal GDP per capita growth, which has contributed to increasing the burden of overweight alone or coexisting with stunting (double burden) among children in the most socio-economically vulnerable strata of the population.
Neurological Complications and Recovery Rates of Patients With Adult Cervical Deformity Surgeries

Study Design: Retrospective cohort study. Objective: This study aims to report the incidence, risk factors, and recovery rate of neurological complications (NC) in patients with adult cervical deformity (ACD) who underwent corrective surgery. Methods: ACD patients undergoing surgery from 2013 to 2015 were enrolled in a prospective, multicenter database. Patients were separated into 2 groups according to the presence of neurological complications (NC vs no-NC groups). The types, timing, recovery patterns, and interventions for NC were recorded. Patients’ demographics, surgical details, radiographic parameters, and health-related quality of life (HRQOL) scores were compared. Results: 106 patients were prospectively included. Average age was 60.8 years with a mean of 18.2 months follow-up. The overall incidence of NC was 18.9%; of these, 68.1% were major complications. Nerve root motor deficit was the most common complication, followed by radiculopathy, sensory deficit, and spinal cord injury. The proportion of complications occurring within 30 days of surgery was 54.5%. The recovery rate from neurological complication was high (90.9%), with most of the recoveries occurring within 6 months and continuing even after 12 months. Only 2 patients (1.9%) had continuous neurological complication. No demographic or preoperative radiographic risk factors could be identified, and anterior corpectomy and posterior foraminotomy were found to be performed less in the NC group. The final HRQOL outcome was not significantly different between the 2 groups. Conclusions: Our data is valuable to surgeons and patients to better understand the neurological complications before performing or undergoing complex cervical deformity surgery.
Pyridinic Nanographenes by Novel Precursor Design

Abstract In this work we present the solution‐synthesis of pyridine analogues to hexa‐peri‐hexabenzocoronene (HBC)—which might be called superpyridines—via a novel precursor design. The key step in our strategy was the pre‐formation of the C−C bonds between the 3/3’ positions of the pyridine and the adjacent phenyl rings—bonds that are otherwise unreactive and difficult to close under Scholl‐conditions. Apart from the synthesis of the parent compound we show that classical pyridine chemistry, namely oxidation, N‐alkylation and metal‐coordination is applicable to the π‐extended analogue. Furthermore, we present basic physical chemical characterizations of the newly synthesized molecules. With this novel synthetic strategy, we hope to unlock the pyridine chemistry of nanographenes.
Sorafenib Induced Hand-Foot Skin Reaction at Low Dose

© 2020 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow Sir, Sorafenib, a small multikinase inhibitor, is the Food and Drug Administration (FDA) approved for the treatment of advanced hepatocellular carcinoma and second‐line treatment of primary renal cell carcinoma (RCC). Out of the various cutaneous side effects known to it, hand‐foot skin reaction (HFSR) is one of the commonest cutaneous toxicity. We report a case of HFSR in a patient of RCC treated with sorafenib at the dose of 200 mg twice daily.
The Association between Moral Distress and Moral Courage in Nurses: A Cross-Sectional Study in Iran

Background: Moral distress and moral courage among healthcare professionals have received considerable attention in recent years. However, there is a paucity of studies investigating these topics among nurses. Thus, the present study aimed to evaluate the association between moral distress and moral courage among nurses in an Iranian sample population. Materials and Methods: The present cross-sectional study was conducted during February–December 2018. Corley's Moral Distress (MDS-R) and Sekerka's moral courage scales were used to collect the data. MDS-R is a 21-items scale which includes frequency and intensity ranges from 0 (never) to 4 (very frequently) and 0 (none) to 4 (great extent), respectively. In addition, the moral courage scale contains 15 items ranging from “never true” (1 point) to “always true” (7 points). In total, 225 eligible nurses were entered into this study. Finally, SPSS-16 was used for statistical analysis at the α = 0.05 level. Results: The mean scores of the frequency and intensity of moral distress and moral courage were 45.41 (95% CI = 43.37-47.45), 44.24 (95% CI = 42.98-45.42), and 59.63 (95% CI = 58.50-60.87), respectively. Eventually, a significant relationship was found between the moral courage and frequency of moral distress (r = 0.46, p < 0.001) and the intensity of moral distress (r = 0.73, p < 0.001). Conclusions: In general, encouraging healthcare managers and administrators is considered as crucial for developing supportive structures and highly sensitive management which promotes moral courage while reducing moral distress in nurses' work setting.
Factors Affecting Women's Adjustment to Postpartum Changes: A Narrative Review

Background: Postpartum period is associated with stress and pressure, and the woman must adjust herself to these changes. This study aimed to review the factors affecting women's adjustment to postpartum changes in conducted studies. Materials and Methods: This review was conducted by searching databases such as ISI Web of Science, Science Direct, Scopus, Cochrane, PubMed and Scientific Information Database (SID), Iranian Medical Articles Database (IranMedex), Iranian Research Institute for Information Science and Technology (IranDoc), and the Iranian Magazine Database (MagIran), as well as searching through Google Scholar (as a Web search engine) in December 2019. Publications from July 2004 to October 2019 were reviewed and limited to Persian and English. The keywords used included “Postpartum”, “Women's needs”, “Adjustment” and “Coping”. After reviewing the articles, out of 60 original articles, 17 articles were selected for final evaluation. Results: Factors affecting adjustment to postpartum changes were divided into personal and social factors. Personal factors included previous experiences, coping styles and strategies, personality traits, self-efficacy and awareness, and social factors included family and relatives, healthcare providers, cultural context, and laws and regulations. Conclusions: Adjustment to postpartum changes depends on the personal and social factors that can interact with each other. Women's awareness enables them to use positive coping strategies in this critical situation. Educating women's spouse and family members can contribute to increase the women's social support. Additionally, the law support guarantees the implementation of many interventions in promoting the mother's health.
Wykorzystanie suchego lodu do dezintegracji osadu czynnego nadmiernego w celu intensyfikacji procesu fermentacji metanowej

Disintegration by dry ice has a positive effect on the degree and rate of surplus activated sludge anaerobic digestion. By applying thermal disintegration the lysis of cells occurs in minutes instead of days. The intracellular and extracellular components are set free and are immediately available for biological degradation which leads to an improvement of the subsequent anaerobic process. Thermal disintegration by dry ice of the surplus activated sludge results in organic matter and a polymer transfer from the solid phase to the liquid. During disintegration process soluble chemical oxygen demand (SCOD) value and proteins concentration increase about 583 and 265 mg/dm, respectively. In the same time concentration of carbohydrates increase about 53 mg/dm. In addition the degree of thermal disintegration changed from 13% for the volume ratio of dry ice to surplus activated sludge 0.25:1 to 49% for the volume ratio of dry ice to sludge 1:1. The addition of thermal disintegrated sludge (30% SASDI of volume) to the digestion process leads to increased biogas production about 49%.
Botanical origin discrimination of Greek honeys: Physicochemical parameters vs Raman spectroscopy.

BACKGROUND The authenticity of honey is of high importance since it affects its commercial value. The discrimination of the origin of honey is of prime importance to reinforce the consumer trust. In this study four chemometric models were developed based on the physicochemical parameters according to European and Greek legislation and one using Raman spectroscopy to discriminate Greek honey samples from three commercial monofloral botanical sources. RESULTS The results of physicochemical (glucose, fructose, electrical activity) parameters chemometric models showed that the percentage of correct recognition was fluctuated from 92.2 to 93.8% with cross-validation 90.6-92.2%, and the placement of test set was 79.0-84.3% successful. The addition of maltose content in the previous discrimination models did not improve significantly the discrimination. The corresponding percentages of Raman chemometric model were found 95.3, 90.6, and 84.3%. CONCLUSION The five developed chemometric models presented similar and very satisfactorily results. Given that the recording of Raman spectra is simple, fast, a minimal amount of sample is needed for the analysis, no solvent (environmentally friendly) is used, and no specialized personnel are required we conclude that the chemometric model based on the Raman spectroscopy is an efficient tool to discriminate the botanical origin fir pine and thyme honey varieties. This article is protected by copyright. All rights reserved.
Thought-Actuated Wheelchair Navigation with Communication Assistance Using Statistical Cross-Correlation-Based Features and Extreme Learning Machine

Background: A simple data collection approach based on electroencephalogram (EEG) measurements has been proposed in this study to implement a brain–computer interface, i.e., thought-controlled wheelchair navigation system with communication assistance. Method: The EEG signals are recorded for seven simple tasks using the designed data acquisition procedure. These seven tasks are conceivably used to control wheelchair movement and interact with others using any odd-ball paradigm. The proposed system records EEG signals from 10 individuals at eight-channel locations, during which the individual executes seven different mental tasks. The acquired brainwave patterns have been processed to eliminate noise, including artifacts and powerline noise, and are then partitioned into six different frequency bands. The proposed cross-correlation procedure then employs the segmented frequency bands from each channel to extract features. The cross-correlation procedure was used to obtain the coefficients in the frequency domain from consecutive frame samples. Then, the statistical measures (“minimum,” “mean,” “maximum,” and “standard deviation”) were derived from the cross-correlated signals. Finally, the extracted feature sets were validated through online sequential-extreme learning machine algorithm. Results and Conclusion: The results of the classification networks were compared with each set of features, and the results indicated that μ (r) feature set based on cross-correlation signals had the best performance with a recognition rate of 91.93%.
A conserved malaria parasite antigen Pb22 plays a critical role in male gametogenesis in Plasmodium berghei

Gametogenesis, the formation of gametes from gametocytes, an essential step for malaria parasite transmission, is targeted by transmission‐blocking drugs and vaccines. We identified a conserved protein (PBANKA_0305900) in Plasmodium berghei, which encodes a protein of 22 kDa (thus named Pb22) and is expressed in both asexual stages and gametocytes. Its homologues are present in all Plasmodium species and its closely related, Hepatocystis, but not in other apicomplexans. Pb22 protein was localised in the cytosols of schizonts, as well as male and female gametocytes. During gamete‐to‐ookinete development, Pb22 became localised on the plasma membranes of gametes and ookinetes. Compared to the wild‐type (WT) parasites, P. berghei with pb22 knockout (KO) showed a significant reduction in exflagellation (~89%) of male gametocytes and ookinete number (~97%) during in vitro ookinete culture. Mosquito feeding assays showed that ookinete and oocyst formation of the pb22‐KO line in mosquito midguts was almost completely abolished. These defects were rescued in parasites where pb22 was restored. Cross‐fertilisation experiments with parasite lines defective in either male or female gametes confirmed that the defects in the pb22‐KO line were restricted to the male gametes, whereas female gametes in the pb22‐KO line were fertile at the WT level. Detailed analysis of male gametogenesis showed that 30% of the male gametocytes in the pb22‐KO line failed to assemble the axonemes, whereas ~48.9% of the male gametocytes formed flagella but failed to egress from the host erythrocyte. To explore its transmission‐blocking potential, recombinant Pb22 (rPb22) was expressed and used to immunise mice. in vitro assays showed that the rPb22‐antisera significantly inhibited exflagellation by ~64.8% and ookinete formation by ~93.4%. Mosquitoes after feeding on rPb22‐immunised mice also showed significant decreases in infection prevalence (83.3–93.3%) and oocyst density (93.5–99.6%). Further studies of the Pb22 orthologues in human malaria parasites are warranted.
Diabetic Control Agents and Their Impact on Cardiac Surgery Patients: A Clinical Overview

Chronic hyperglycemia is associated with poor cardiovascular surgical outcomes due to microvascular and macrovascular complications. This is a major concern as over one third of cardiovascular surgical patients have diabetes mellitus which greatly increases their risk of experiencing adverse cardiovascular events. A literature review was performed to identify articles discussing the effects of anti-diabetic medications (ADMs) on cardiovascular outcomes and surgical mortality and morbidity rates. Optimizing perioperative glucose levels remains a key factor in producing good surgical outcomes. In addition, recognizing gender differences, increasing patient satisfaction, and implementing dedicated diabetic teams all improve surgical mortality and morbidity rates in the diabetic population.
The Relation between Atherosclerosis Plaque Composition and Plaque Rupture

Background: Intima, media, and adventitia are three layers of arteries. They have different structures and different mechanical properties. Damage to intima layer of arteries leads to an inflammatory response, which is usually the reason for atherosclerosis plaque formation. Atherosclerosis plaques mainly consist of smooth muscle cells and calcium. However, plaque geometry and mechanical properties change during time. Blood flow is the source of biomechanical stress to the plaques. Maximum stress that atherosclerosis plaque can burden before its rupture depends on fibrous cap thickness, lipid core, calcification, and artery stenosis. When atherosclerotic plaque ruptures, the blood would be in contact with coagulation factors. That is why plaque rupture is one of the main causes of fatality. Method: In this article, the coronary artery was modeled by ANSYS. First, fibrous cap thickness was increased from 40 μm to 250 μm by keeping other parameters constant. Then, the lipid pool percentage was incremented from 10% to 90% by keeping other parameters unchanged. Furthermore, for investigating the influence of calcium in plaque vulnerability, calcium was modeled in both agglomerated and microcalcium form. Results: It is proved that atherosclerosis plaque stress decreases exponentially as cap thickness increases. Larger lipid pool leads to more vulnerable plaques. In addition, the analysis showed maximum plaque stress usually increases in calcified plaque as compared with noncalcified plaque. Conclusion: The plaque stress is dependent on whether calcium is agglomerated near the lumen or far from it. However, in both cases, the deposition of more calcium in calcified plaque reduces maximum plaque stress.