Miracle-dz/UniFAR-FTUs huggingface dataset:
Global Aesthetics Consensus: Hyaluronic Acid Fillers and Botulinum Toxin Type A—Recommendations for Combined Treatment and Optimizing Outcomes in Diverse Patient Populations

Background: Combination of fillers and botulinum toxin for aesthetic applications is increasingly popular. Patient demographics continue to diversify, and include an expanding population receiving maintenance treatments over decades. Methods: A multinational panel of plastic surgeons and dermatologists convened the Global Aesthetics Consensus Group to develop updated guidelines with a worldwide perspective for hyaluronic acid fillers and botulinum toxin. This publication considers strategies for combined treatments, and how patient diversity influences treatment planning and outcomes. Results: Global Aesthetics Consensus Group recommendations reflect increased use of combined treatments in the lower and upper face, and some midface regions. A fully patient-tailored approach considers physiologic and chronologic age, ethnically associated facial morphotypes, and aesthetic ideals based on sex and culture. Lower toxin dosing, to modulate rather than paralyze muscles, is indicated where volume deficits influence muscular activity. Combination of toxin with fillers is appropriate for several indications addressed previously with toxin alone. New scientific data regarding hyaluronic acid fillers foster an evidence-based approach to selection of products and injection techniques. Focus on aesthetic units, rather than isolated rhytides, optimizes results from toxin and fillers. It also informs longitudinal treatment planning, and analysis of toxin nonresponders. Conclusions: The emerging objective of injectable treatment is facial harmonization rather than rejuvenation. Combined treatment is now a standard of care. Its use will increase further as we refine the concept that aspects of aging are intimately related, and that successful treatment entails identifying and addressing the primary causes of each. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V.
Selective Induction of Colon Cancer Cell Apoptosis by 5-Fluorouracil in Humans

To assess the mechanism of action of 5-fluorouracil (5-FU) apoptosis (AI) and proliferation (PI) indices were determined histochemically in colon carcinoma and normal colon tissue of 7 patients treated preoperatively with 5-FU (300 mg/m2/day for 5 days) and 11 controls. 5-Fluorouracil induced apoptosis selectively in malignant colonocytes (AI in 5-FU-group: 0.126±0.016 [mean±SEM] vs. 0.065±0.012 in controls; P<0.05), but not in normal colonocytes. 5-Fluorouracil had no effect on the PI of either normal or malignant colonocytes. 5-Fluorouracil-induced apoptosis did not correlate with clinical outcome at 24 months. We conclude that 5-FU: (a) induces apoptosis selectively in colon cancer cells, while it spares the normal colonic mucosa, and (b) has no effect on colonocyte proliferation under the conditions of our protocol. This effect of 5-FU may contribute to its chemotherapeutic activity in human colon cancer.
Spread through air spaces (STAS): prognostic impact of a semi-quantitative assessment.

Following validation in two large independent cohorts from the US and Germany (1,2), the concept of spread through air spaces (STAS) was introduced for pulmonary adenocarcinomas (ADC) in the 2015 World Health Organization (WHO) Classification for lung cancer and subsequently validated and extended (3). Now, Uruga et al . provided evidence that a semi-quantitative assessment of STAS might provide additional prognostic information (4).
Light-Directed Tuning of Plasmon Resonances via Plasmon-Induced Polymerization Using Hot Electrons

The precise morphology of nanoscale gaps between noble-metal nanostructures controls their resonant wavelengths. Here we show photocatalytic plasmon-induced polymerization can locally enlarge the gap size and tune the plasmon resonances. We demonstrate light-directed programmable tuning of plasmons can be self-limiting. Selective control of polymer growth around individual plasmonic nanoparticles is achieved, with simultaneous real-time monitoring of the polymerization process in situ using dark-field spectroscopy. Even without initiators present, we show light-triggered chain growth of various monomers, implying plasmon initiation of free radicals via hot-electron transfer to monomers at the Au surface. This concept not only provides a programmable way to fine-tune plasmons for many applications but also provides a window on polymer chemistry at the sub-nanoscale.
On elimination of variables in the study of singularities in positive characteristic

The objective of this paper is to discuss invariants of singularities of algebraic schemes over fields of positive characteristic, and to show how they yield the simplification of singularities. We focus here on invariants which arise in an inductive manner, namely by successive elimination of variables. When applied to hypersurface singularities they lead us to a refinement of the notion of multiplicity. The main theorem proves that, under some numerical conditions expressed by these invariants, singularities can be simplified by blowups at centers prescribed by this refinement.
A low cost approach to acoustic filters acting as GPR cooperative targets for passive sensing

Ground Penetrating RADAR (GPR) is a classical sub-surface analysis tool widely used in civil engineering and environmental investigations. Currently limited to monitoring passive buried dielectric and conductivity interfaces, the instrument is perfectly suited to probe cooperative targets made of piezoelectric substrates designed to convert the incoming electromagnetic wave to an acoustic wave. The surface acoustic wave (SAW) velocity is strongly dependent on the physical environment of the transducer, allowing for sensing such quantities as temperature, stress or the presence of chemical compounds. In order to demonstrate the compatibility of SAW sensors acting as cooperative targets probed by GPR, we investigate the use of widely available commercial SAW filters for sensing purposes. Dedicated software for recording the Malå ProEx GPR signal and digital signal processing algorithms for extracting the physical quantity are demonstrated.
Review of integrated vehicle dynamics control architectures

Most of the chassis systems are developed by automotive suppliers to improve a specific vehicle performance. Drivers, and consequently vehicle manufacturers, are more concerned by the overall behaviour of the Vehicle. Many coordination architectures have been proposed in the literature in order to integrate different chassis systems in a single vehicle. In this paper, these architectures are compared and discussed. Two major classes are proposed: Downstream and Upstream Coordination. The purpose of this classification is to help car manufacturers and suppliers standardize an Integrated Vehicle Dynamics Control architecture for faster and more flexible designs.
Detección de neuropatía autonómica cardíaca con maniobras de baja complejidad en atención ambulatoria

Introduccion: la neuropatia autonomica cardiaca (NAC) es una de las complicaciones mas seria y menos estudiada de la diabetes. La alteracion en la variabilidad de la frecuencia cardiaca es el indicador mas precoz de NAC. Actualmente el diagnostico se realiza con las maniobras de Ewing. No todos los centros del pais cuentan con los profesionales capacitados y/o el equipo necesario. Objetivo: detectar NAC con maniobras de baja complejidad y comparar resultados con las pruebas de Ewing. Materiales y metodos: estudio observacional y transversal. Se evaluaron 24 pacientes de la Unidad de Nutricion del Hospital Carlos G. Durand entre el 1 de junio y el 30 de noviembre del 2011. Se realizaron los test de Ewing, se efectuo la medicion de FC y TA en tres posiciones, y se midio el QTc. Resultados: la media de la edad de la muestra poblacional fue de 56,54 anos (47-72), y 15 eran mujeres (62,5%). En las variables de TA y QTc, se hallaron valores dentro de lo normal. En 20 pacientes (83,3%), los valores de FC se encontraron fuera de la normalidad, con un valor predictivo positivo del 80% (VPP) y un valor predictivo negativo del 25% (VPN), con una sensibilidad del 84% (S) y una especificidad del 20% (E). Los resultados de las pruebas de Ewing fueron patologicos en 19 pacientes (S 93%). Conclusion: las maniobras de baja complejidad como la falta de variedad en la frecuencia cardiaca (FVFC), no suplantan al gold estandar pero aportan un elemento de alta sospecha clinica. (AU)
Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect.

BACKGROUND The lack of smart and controllable gene vectors with high safety and efficiency is still a main obstruction for clinical applications of gene therapy. Recently, the external physical stimuli, such as near infrared light induced temperature elevation, have been applied to enhance the gene transfection efficiency and specificity. The aim of this paper is to fabricate chitosan functionalized CuS nanoparticles (CuS@CS NPs) with small size and higher biocompatibility for enhanced gene delivery by photothermal effect. METHODS CuS@CS NPs were successfully prepared by simple hydrothermal method. The biocompatibility was detected by MTT method and hymolytic analysis. pEGFP-C1was used as gene model, and its expression efficiency was detected by fluorescence microscopy and flow cytometry to investigate the effect of photothermal effect on the transfection efficiency. RESULTS The CuS@CS NPs around 15 nm were successfully engineered. The modification of CuS nanoparticles with chitosan conduced to higher physiological stability and biocompatibility. The utilization of CuS@CS NPs in combination with external near infrared (NIR) laser irradiation could enhance gene transfection efficiency due to photothermal effect. The gene transfection efficiency of CuS@CS NPs found to increase from 5.05±0.54% (0 min) to 23.47±1.27% (10 min), significantly higher than the free polyethylenimine (18.15±1.03%). CONCLUSION CuS@CS NPs showed great capability to control gene delivery by an external NIR laser irradiation and enhance the gene transfection efficiency and specificity because of convenient preparation, stabilized optical properties, excellent photothermal effect and good biocompatibility. It encourages further exploration of the CuS@CS NPs as a photocontrollable nanovector for combined photothermal and gene therapy, as well as image guided therapy.
Weighted graph algorithms with Python

Python implementation of selected weighted graph algorithms is presented. The minimal graph interface is defined together with several classes implementing this interface. Graph nodes can be any hashable Python objects. Directed edges are instances of the Edge class. Graphs are instances of the Graph class. It is based on the adjacency-list representation, but with fast lookup of nodes and neighbors (dict-of-dict structure). Other implementations of this class are also possible. In this work, many algorithms are implemented using a unified approach. There are separate classes and modules devoted to different algorithms. Three algorithms for finding a minimum spanning tree are implemented: the Boruvka's algorithm, the Prim's algorithm (three implementations), and the Kruskal's algorithm. Three algorithms for solving the single-source shortest path problem are implemented: the dag shortest path algorithm, the Bellman-Ford algorithm, and the Dijkstra's algorithm (two implementations). Two algorithms for solving all-pairs shortest path problem are implemented: the Floyd-Warshall algorithm and the Johnson's algorithm. All algorithms were tested by means of the unittest module, the Python unit testing framework. Additional computer experiments were done in order to compare real and theoretical computational complexity. The source code is available from the public GitHub repository.
Survivale Network Design Problems with High Connectivity Requirement

Cette these s'inscrit dans le cadre d'une etude polyhedrale des problemes de conception de reseaux fiables avec forte connexite. En particulier, nous considerons les problemes dits du sous-graphe k-arete-connexe et de conception de reseau k-arete-connexe avec contrainte de borne lorsque k _>3. Dans un 1er temps, nous etudions le probleme du sous-graphe k-arete-connexe. Etant donne un graphe non oriente et value G = (V, E) et un entier positif k, le probleme du sous-graphe k-arete-connexe consiste a determiner un sous-graphe de G de poids minimum telle qu'il existe k chaines arete-disjointes entre chaque paire de sommets de V. Nous discutons du polytope associe a ce probleme lorsque k _>3. Nous introduisons une nouvelle famille d'inegalites valides pour le polytope et presentons plusieurs familles d'inegalites valides. Pour chaque famille d'inegalites, nous etudions les conditions sous lesquelles ces inegalites definissent des facettes. Nous discutons aussi du probleme de separation associe a chaque famille d'inegalites ainsi que d'operations de reduction de graphes. En utilisant ces resultats, nous developpons un algorithme de coupes et branchements pour le probleme et donnons des resultats experimentaux. Ensuite, nous etudions le probleme de conception de reseaux k-arete-connexe avec contrainte de borne. Soient G = (V, E) un graphe value non oriente, un ensemble de demandes D _C V x V et deux entiers positifs k et L. Le probleme de conception de reseaux k-arete-connexe avec contrainte de borne consiste a determiner un sous-graphe de G de poids minimum telle qu'entre chaque paire de sommets {s, t} E D, il existe k chaines arete-disjointes de longueur au plus L. Nous etudions ce probleme dans le cas ou k _>2 et L E {2, 3}. Nous examinons la structure du polytope associe et montrons que, lorsque I D I = 1, ce polytope est completement decrit par les inegalites dites de st-coupe et de L-chemin-coupe avec les inegalites triviales. Ce resultat generalise ceux de Huygens et al. [75] pour k = 2, L E {2, 3} et Dahl et al. [35] pour k _>2, L = 2. Enfin, nous nous interessons au probleme de conception de reseau k-arete-connexe avec contrainte de borne lorsque k _>2, L E {2, 3} et I D I _> 2. Le probleme est NP-difficile dans ce cas. Nous introduisons quatre nouvelles formulations du probleme sous la forme de programmes lineaires en nombres entiers. Celles-ci sont basees sur la transformation du graphe G en graphes orientes appropries. Nous discutons du polytope associe a chaque formulation et introduisons plusieurs familles d'inegalites valides. Pour chacune d'elles, nous decrivons des conditions pour que ces inegalites definissent des facettes. En utilisant ces resultats, nous developpons des algorithmes de coupes et branchements et de coupes, generation de colonnes et branchements pour le probleme. Nous donnons des resultats experimentaux et menons une etude comparative entre les differentes formulations
Local SVD inverse of robot Jacobians

This study presents a fast inverse kinematics algorithm for a class of robots, including PUMA and SCARA. It decomposes a robot Jacobian into a product of sub-matrices to locate singularities. Singular value decomposition (SVD) is applied to each singular sub-matrix to find a local least-squares inverse. Perfect inverses are derived for all non-singular sub-matrices. The proposed algorithm is extremely fast. A total inverse requires 54 flops for PUMA and 43 for SCARA. Simulation and experiment are conducted to test the accuracy and real-time speed of the algorithm.
An Integrated Approach to Forecast the Future Requests of User by Weblog Mining

With the wide availability of information over the internet and amount of its’ potential users’ makes it challenging for service provider to make such relevant information available to users in a fast and personalized manner nowadays, resulting in decrease in the web performance. One way to tackle with this challenging issue is to use prediction or recommendation technique, which can make users to discover future offerings. Web Usage Mining is a discipline, where the navigational access behavior of users’ over the web is tracked and scrutinized. By collecting and analyzing this behavior of user activities, websites owner can easily identify the web access patterns of its users’. The mining of user access logs could help to improve the performance of search engines, since users have a specific goal when searching for information. In this paper, an approach is proposed to get more accurate prediction results by using both bi-clustering and greedy search method. The predictions of users’ future access requests will be made by this can improve the accuracy of results and will helps in order to reduce the search time. General Terms Data Mining
An Exposed Domain in the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Induces Neutralizing Antibodies

ABSTRACT Exposed epitopes of the spike protein may be recognized by neutralizing antibodies against severe acute respiratory syndrome (SARS) coronavirus (CoV). A protein fragment (S-II) containing predicted epitopes of the spike protein was expressed in Escherichia coli. The properly refolded protein fragment specifically bound to the surface of Vero cells. Monoclonal antibodies raised against this fragment recognized the native spike protein of SARS CoV in both monomeric and trimeric forms. These monoclonal antibodies were capable of blocking S-II attachment to Vero cells and exhibited in vitro antiviral activity. These neutralizing antibodies mapped to epitopes in two peptides, each comprising 20 amino acids. Thus, this region of the spike protein might be a target for generation of therapeutic neutralizing antibodies against SARS CoV and for vaccine development to elicit protective humoral immunity.
Oxidant stress and carcinogenesis

Oxidant carcinogens are of particular relevance to human carcinogenesis because of their ubiquitous occurrence in our environment and their generation in tissues by metabolic reactions and inflammatory processes [1,2]. Oxidants can act at several stages in malignant transformation. They induce permanent DNA sequence changes in the form of point mutations [3,4], deletions, gene amplification and rearrangements which may result in the activation of protooncogenes or the inactivation of tumour suppressor genes. Besides hereditary structural DNA alterations oxidants can trigger epigenetic pathways which result in the transitory activation of genes which participate in the regulation of growth and differentiation. Over the last several years we have studied the cytoplasmic signal transduction pathways and the nuclear events which are activated in mammalian cells by a burst of extracellular active oxygen of the type released into tissues by inflammatory leucocytes [5]. We observed that pathways used by polypeptide growth factors and hormones are also activated by oxidants. A rapid increase in Ca2+ represents a crucial initial trigger. Oxidants stimulate the phosphorylation of the ribosomal subunit S6 [6], the phosphotransferase activity of protein kinase C and induce its translocation to the plasma membrane [7]. On the genomic level, oxidants increase the expression of the growth-competencerelated protooncogenes c-fos, c-jun and c-myc as well as p-actin [8,9]. Protein phosphorylation participates in c-fos induction by oxidants since kinase inhibitors suppress the reaction (P. Amstad, G. Shah & P. Cerutti, unpublished). In addition to these growthfactor-type reactions, oxidants activate pathways which are unique to them [l]. They induce DNAstrand breakage mostly via the stimulation of a Ca2+dependent endonuclease [ 101 and, the poly ADP
Demonstration of High-Density Removable Disk System Using Barium-Ferrite Particulate and CoPtCr-SiO$_2$Thin Film Flexible Media

To make removable, flexible disk drives (FDDs) a practical solution for modern backup, archiving, and data sharing, current areal density capabilities must be improved. In this paper, we study prototype drive-level performance of two types of flexible media. Using giant magneto-resistive heads, a partial-response maximum-likelihood channel, and a robust error-correction coding scheme, we evaluated signal-to-noise ratios, byte-error rates, pulse widths, and off-track read capabilities for each media type. Our results demonstrate the feasibility of FDD areal densities at 17.5 Gb/in2 using barium-ferrite particulate media, and 31 Gb/in2 using CoPtCr-SiO2 sputtered media
A Design of 6-bit 125-MS/s SAR ADC in 0.13-µm MM/RF CMOS Process

The design of a 6bit 125MS/s Successive Approximation (SAR) Analog to Digital Converter (ADC) that uses modified switching technique has been presented in this paper. This modified switching technique requires only half the number capacitors and achieves a switching energy reduction of about 91.5% when compared with conventional SAR ADC approach. This scheme also reduces by half the DAC capacitor array output settling time during bit cycling sequence. This SAR ADC with modified switching technique has been designed and simulated in UMC 0.13u MM/RF CMOS process. This design works with the clock frequency of 1GHz achieving a maximum sampling rate of 125MS/s and consumes 5.16mW power with 1.2V supply voltage and 800mVpp differential input range. The simulated dynamic performance indicates an SNDR and SFDR of 37.97dB and 54.35dB respectively.
Human Cancer Biology Expression and Functional Significance of HtrA 1 Loss in Endometrial Cancer

Purpose: The purpose of this study was to determine if loss of serine protease HtrA1 in endometrial cancer will promote the invasive potential of EC cell lines. Experimental design: Western blot analysis and immunohistochemistry methods were used to determine HtrA1 expression in EC cell lines and primary tumors, respectively. Migration, invasion assays and in vivo xenograft experiment were performed to compare the extent of metastasis between HtrA1 expressing and HtrA1 knocked down clones. Results:Western blot analysis of HtrA1 in 13 EC cell lines revealed complete loss of HtrA1 expression in all seven papillary serous EC cell lines. Downregulation of HtrA1 in Hec1A and Hec1B cell lines resulted in a threeto fourfold increase in the invasive potential. Exogenous expression of HtrA1 in Ark1 and Ark2 cells resulted in threeto fourfold decrease in both invasive and migration potential of these cells. There was an increased rate of metastasis to the lungs associated with HtrA1 downregulation in Hec1B cells compared to control cells with endogenous HtrA1 expression. Enhanced expression of HtrA1 in Ark2 cells resulted in significantly less tumor nodules metastasizing to the lungs compared to parental or protease deficient (SA mutant) Ark2 cells. Immunohistochemical analysis showed 57% (105/184) of primary EC tumors had low HtrA1 expression. The association of low HtrA1 expression with high-grade endometrioid tumors was statistically significant (P 1⁄4 0.016). Conclusions: Collectively, these data indicate loss of HtrA1 may contribute to the aggressiveness and metastatic ability of endometrial tumors. Clin Cancer Res; 17(3); 427–36. 2010 AACR.
A proxy partially blind signature approach using elliptic curve cryptosystem

Partially blind signature is cryptographic system that is used in several protocols including e-cash and e-commerce systems. In proxy partially blind signature, part of the message is approved by the signer and the signature supplicant. Elliptic curve discrete logarithmic (ECDL) is an extremely difficult to solve problem as compared to any standard inverse operation of a one-way-trap door function including discrete logarithm problem or factorisation problem. In this paper, we propose a new proxy partially blind signature scheme based on ECDL. The main attractive features of the proposed scheme are the low computational cost and the low communication overhead. Moreover, the new scheme provides an extra level of security properties of both the partially blind signature and proxy signature. Several security analysis are shown to prove the security and the efficiency of the proposed scheme.