Miracle-dz/UniFAR-FTUs huggingface dataset:
European neuroborreliosis: Long term follow-up

Lyme disease is the most common human tick borne disease in the northern hemisphere, and the southern coastline of Norway is a high endemic region regarding Lyme disease. European Lyme neuroborreliosis (LNB) often presents with a sub acute painful lymphocytic meningoradiculitis (Bannwarth syndrome) with or without paresis in the abdominal wall, the limbs or muscles innervated by cranial nerves. Central nervous system involvement as encephalitis, myelitis and vasculitis is rare. Most LNB patients experience marked improvement in neurological symptoms within weeks to a few months after antibiotic treatment, but years after treatment 10 – 50% report persisting or new symptoms including fatigue, concentration difficulties and musculoskeletal problems. Remaining complaints after adequately treated Bb infections are often named Post Lyme Disease Syndrome (PLDS). The prevalence and impact of PLDS is debated since similar symptoms are common in the general population, and there are few European controlled studies on the issue. Most studies on outcome after LNB are conducted in the US, and as Borrelia genotype and the clinical picture of Lyme disease in the US differ somewhat from what we find in Europe, the study results are not necessarily transferable to European patients. Aims Our aim was to assess the long-term impact of LNB on Health Related Quality of Life (HRQoL) in a controlled study of well-characterized adult European LNB patients. We also wanted to compare the neuropsychological (NP) functioning by assessing executive/attention functions, processing speed and memory in a group of adult LNB patients 30 months after treatment to a matched control group. Finally, we wanted to identify clinical, demographical or laboratory factors associated with a reduced HRQoL and fatigue after treatment of LNB. Patients and methods A cohort of 50 patients was followed for 30 months after treatment for LNB. The patients were recruited from a treatment study conducted in southern Norway comparing per oral doxycycline to intravenous ceftriaxone. All patients were living in the geographical region of Agder Counties, and received treatment between May 2004 and December 2007. The LNB patients brought a control person from the same geographical area, matched for age, gender and education level. Exclusion criterion for the controls was a history of acknowledged LNB.
SNP rs2157719 in the CDKN2B-AS1 gene may influence cup-to-disc ratio in patients with primary open angle glaucoma

Background: Several studies have provided strong evidence that gene variants at the cyclin-dependent kinase inhibitor 2B antisense non-coding RNA (CDKN2BAS1) locus of 9p21 is an important risk factor in the development of primary open angle glaucoma (POAG) making it a strong candidate for risk factor screening. Objectives: The present study investigated the possible association of SNP rs2157719 in CDKN2B-AS1 with POAG and specific glaucoma indices used to assess disease severity in a Saudi cohort. Materials and methods: Genotyping of SNP rs2157719 was performed in 85 unrelated POAG cases and 95 normal controls of Saudi origin using Taq-Man® realtime PCR assay and its association with the POAG and other clinical indices was evaluated. Results: The genotype frequencies did not deviate significantly from the Hardy-Weinberg equilibrium (p>0.05). The minor ‘G’ allele frequency was observed to be 0.18 in cases and 0.21 in controls. Both the genotype and allele frequencies did not vary significantly between cases and controls. However, the homozygous mutant genotype (G/G) was found to be significantly associated with family history of glaucoma (p= 0.018), smoking (p= 0.033) and awareness of glaucoma (p= 0.039). In addition, carriers of the heterozygous (A/G) genotype had significantly higher cup/disc ratio (p= 0.028) as compared to the wild-type. Conclusion: SNP rs2157719 in the CDKN2B-AS1 is not associated with POAG but may affect cup-to-disc ratio and thereby modulate optic nerve pathology.
A ALIMENTAÇÃO E SEU LUGAR NA HISTÓRIA:OS TEMPOS DA MEMÓRIA GUSTATIVA

O texto trata do estado da arte relativo ao tema da Historia da Alimentacao, destacando os conceitos, fundamentos e referenciais teorico-metodologicos colocados em evidencia por meio de uma importante base historiografica, com obras, textos e projetos de pesquisa que apontam o lugar da alimentacao na Historia.
Un état de l'art des méthodes de localisation de symboles dans les documents graphiques

Dans cet article, nous proposons un panorama de methodes de localisation de symboles dans les documents graphiques. Nous les divisons suivant deux categories : les approches structurelles et les pixelaires. Les approches structurelles sont basees souvent sur des representations de types graphes et possedent generalement une etape de segmentation prealable des documents en primitives. Le symbole est ensuite detecte via une etape de regroupements de primitives et sous certaines conditions. Dans les approches pixelaires, la localisation est effectuee directement sur les documents sans etape prealable de segmentation.
Helicobacter pylori: Basic Mechanisms to Clinical Cure

Since its rediscovery 10 years ago, Helicobacter pylori has reshaped our thinking about the course of peptic ulcer disease. Our approach to the patient with a duodenal ulcer has become one of attempting eradication therapy at the time of first diagnosis, in the hope of curing the ulcer disease. Gastric and duodenal ulceration are only two of the manifestations of this chronic antral infection; other complications of H pylori include gastritis, gastric cancer and possible maltomas. Therapy of H pylori infection is complicated and involves dual therapy with an antibiotic plus a protein pump inhibitor, such as omeprazole 20 mg bid plus amoxicillin 1 g bid for two weeks, triple or quadruple therapy with bismuth, two antibiotics and an H2-receptor antagonist. Vaccination against H pylori is on the far horizon.
Orchestrer les actifs pour rester concurrentiel. La trajectoire stratégique de Raytheon.

Quelle peut etre la strategie d'une entreprise pour rester concurrentielle dans un environnement en pleine mutation ? Les acteurs du changement modifient-ils leurs representations et leurs pratiques au rythme de ces ruptures ? A partir du cas de Raytheon, industrie de defense americaine, l'auteure montre comment une entreprise essaie d'aborder le futur de maniere durablement innovante, comment elle construit sa « capacite dynamique ». A chaque changement important de l'environnement (fin de la Guerre Froide, revolution technologique actuelle), l'entreprise a cherche a orchestrer au mieux ses actifs pour anticiper l'avenir. Mais vendre et acheter des actifs, tout en reorganisant ses propres ressources, le tout sous l'oeil vigilant des marches financiers qui ne manquent pas d'interpreter les nominations des dirigeants, voila qui laisse deviner l'incertitude qui pese sur le succes d'une telle orchestration
Measurement of Pressure During Intravenous Therapy

To the Editor:— A simple technique for monitoring central venous pressure has been employed in patients at the Veterans Administration Hospital, Brecksville, Ohio, for the past two years. It consists of inserting a No. 16 gauge polyethylene tube percutaneously through a 14-gauge, short bevel needle and threading the tubing into the superior vena cava. This technique is considered better and more easily accomplished than previously described techniques of antecubital cut-down or subclavicular cannulization of the subclavian vein. Dissatisfaction with the latter techniques led to the utilization of the internal jugular vein as a route for monitoring central venous pressures and for administering intravenous therapy. 1,2 Technique:— The patient is placed in the Trendelenburg position and sterile technique is employed. Working from a cephalad position, the physician infiltrates a local anesthetic (1% lidocaine) into an area approximately 3 cm lateral to the midsternal line and 2 to 3 cm above the
The hospital delay analysis of intravenous thrombolysis process among ischemic stroke patients based on value stream mapping

Objective: To analyze systematically the effect of value stream map of intravenous thrombolysis process among ischemic stroke patients and to provide the basis for process optimization. Methods: Totally 31 ischemic stroke patients with intravenous thrombolysis were recruited by purposive sampling methods and were followed up throughout the whole study. We drawed the value stream map and analyzed the activities in the hospital. Results: The mean time of hospital intravenous thrombolysis among ischemic stroke patients was 81-196 minutes, the process time was 45-98 minutes, the delay time was 36-98 minutes. Conclusion: The intravenous thrombolysis process among ischemic stroke patients has a great improvement space. The key measures to optimize intravenous thrombolysis process were timely and accurate evaluation, the cooperation and communication of each department, visual management, and diverse informed consent form.
Exposure informed testing under REACH

De mate waarin mensen blootstaan aan chemicalien kan het aantal testen met proefdieren beinvloeden dat nodig is om de veiligheid van een stof te beoordelen. Dit betekent dat bepaalde onderzoeken niet nodig zijn als mensen of organismen in het milieu niet of nauwelijks aan een stof staan blootgesteld (Exposure Based Waiving, EBW). Hierdoor zijn minder proefdieren nodig. Bij relatief hoge blootstellingen kunnen juist extra testen met proefdieren nodig zijn (Exposure Based Triggering, EBT). Goede kennis van deze blootstelling via modellering of meting is hiervoor onontbeerlijk, zowel voor EBW als EBT. Dit geldt voor alle relevante stadia in de levenscyclus van een stof, van productie tot de afvalfase. Alleen dan kan gezegd worden of een blootstelling niet of juist wel relevant is. Het gaat om blootstelling van de mens, direct via consumentenproducten of op de werkplek of indirect via het milieu, en om blootstelling van organismen in het milieu. Het RIVM en TNO hebben onderzocht hoe dit onderdeel van teststrategieen kan worden aangewend om proefdiergebruik te verminderen. Het rapport is een deelproduct van het Europese Zesde Kaderproject OSIRIS (Optimized Strategies for Risk Assessment of Industrial Chemicals through Integration of Non-Test and Test Information). Doel van dit project is om teststrategieen te ontwikkelen voor toepassing onder REACH die het proefdiergebruik kunnen verminderen. De nieuwe Europese Verordening voor registratie, beoordeling, autorisatie en beperkingen voor chemische stoffen (REACH) verplicht de industrie om een registratiedossier voor haar stoffen in te dienen. De verplichte testen zijn in REACH vastgelegd en afhankelijk van de hoeveelheid stof die op de markt komt. Onder bepaalde voorwaarden, zoals de mate van blootstelling, kan hiervan worden afgeweken.
Human Resource Management: Guidelines for Effective Introduction of Microcomputer Technology

Microcomputer technology has matured to a point at which its successful assimilation depends more on the proper management of personnel and less on the features of the technology. This article presents a case study that demonstrates how lead users can be identified and recruited to provide a support infrastructure to peers throughout the initiation stage within the organization. The article recommends that managers of microcomputer technology develop an understanding of different user types and apply adaptive human resource management practices
Non-perturbative approaches to transport in nanostructures and granular arrays

1- Introduccion Los conceptos sobre los que versa el trabajo giran en torno a las interacciones electrostaticas y de intercambio en nano-granos metalicos, redes granulares y su efecto en el transporte. Una nueva tecnica, basada en la descripcion de la superconductividad mediante la accion de un rotor cuantico, y de la misma familia que las tecnicas de bosones esclavos se empleo para describir la coexistencia de el bloqueo de Coulomb y del efecto Kondo en nanoestructuras metalicas. Se realizaro un analisis de la dependencia de estos efectos con los detalles espectrales de la nanoestructura, y se derivaron las consecuencias fisicas que esto tienen en el transporte a traves de sistemas granulares dentro de la ""Teoria de "" campo medio dinamico"" (DMFT), y en concreto en la transicion metal-aislante de Mott. 2- La descripcion del Bloqueo de Coulomb mediante el rotor cuantico. Hicimos una revision cuidadosa de la description del bloqueo de Coulomb en terminos de la dinamica effectiva de la fase del sistema de nanoestructuras normales, como un caso particular de las tecnicas desarrolladas al principio de los ochenta para descibir microscopicamente la dinamica de la fase superconductora en las uniones Josephson. Esto sirve de introduccion tecnica al campo. Se discuteron los conceptos de bloqueo de Coulomb, el cotunneling, la conductancia y la energia de carga renormalizada en el contexto del formalismo. 3- La tjescription del Bloqueo de Coulomb y del efecto Kondo mediante el metodo del rotor esclavo. Una tecnica, analoga a la de los bosones esclavos pero basada en el metodo del rotor cuantico se empleo para describir la coexistencia de ambos efectos de Kondo y de bloqueo de Coulomb en nanoestructuras. Es capaz de tratar nanoestructuras caoticas con un espectro arbitrario. La accion efectiva involucra a fermiones y al rotor y fue tratada dentro de una ""aproximacion sin cruces"" (Non-crossing approximati
The OctaVis: a VR-device for rehabilitation and diagnostics of visuospatial impairments

In an age of unprecedented technological impact on our cognition, this thesis presents interdisciplinary research on a virtual reality device meant to enhance traditional therapy of impairments in spatial thinking resulting from an accident, a stroke or some neuro-degenerative disease. Analyzing common strategies and goals in neuro-psychological therapy, a stark resemblance with general tactics from gameand virtual environment design is disclosed (empowerment, interaction, personal meaning, flow, etc). Additionally, noticing the inability of traditional therapy to transfer training success to real-life situations, a grocery-shopping task tackling executive functions, spatial memory, orientation, and recognition is introduced as a promising rehabilitation scenario for visuospatial recovery. Following the research results on presence and its effects on taskperformance and skill-transfer, the development of a novel VR device – the OctaVis– is presented. It consists of eight touch screens surrounding the patient with a 360◦ panorama view. The patient is seated on an office chair equipped with a joystick in the armrest to move forward/backward and a rotary encoder in the shaft of the chair to determine the virtual moving direction. Being CE-certified, the device meets both, patient and hospital requirements (space & cost efficiency, low maintenance, easy to use by nontechnical staff). To render the virtual environment, while meeting project demands, a custom render framework for a single PC hosting three GPUs to drive eight monitors has been developed and optimized to render the supermarket (4M triangles) at more than 70 fps. To evaluate the device, first, the extension of the horizontal field of view from 135◦ (three displays) to 360◦ (eight displays) is examined regarding its effect on spatial presence and on the accuracy in a pointing task. Second, driving the full eight screens, the effect of embodied self-rotation using the same measures is explored. In particular, navigation by rotating the world while the user is sitting stable is compared to a stable world and a self-rotating user. Finally, several clinical trials with patients confirm the OctaVis to provide stable learning, to generalize training success into real reality, and even to outperform standard diagnostic tests.
Etudes expérimentales et numériques des instabilités non-linéaires et des vagues scélérates optiques

Ces travaux de these rapportent l’etude des instabilites non-lineaires et des evenements extremesse developpant lors de la propagation guidee d’un champ electromagnetique au sein de fibresoptiques. Apres un succinct rappel des divers processus lineaires et non-lineaires menant a lageneration de super continuum optique, nous montrons que le spectre de celui-ci peut presenterde larges fluctuations, incluant la formation d’evenements extremes, dont les proprietes statistiqueset l’analogie avec les vagues scelerates hydrodynamiques sont abordees en detail. Nous presentonsune preuve de principe de l’application de ces fluctuations spectrales a la generation de nombres etde marches aleatoires et identifions le phenomene d’instabilite de modulation, ayant lieu lors de laphase initiale d’expansion spectrale du super continuum, comme principale contribution a la formationd’evenements extremes. Ce mecanisme est etudie numeriquement et analytiquement, en considerantune categorie de solutions exactes de l’equation de Schrodinger non-lineaire presentant descaracteristiques de localisations singulieres. Les resultats obtenus sont verifies experimentalement,notamment grâce a un systeme de caracterisation spectrale en temps reel et a l’utilisation conjointede metriques statistiques innovantes (ex : cartographie de correlations spectrales). L’excellent accordentre simulations et experiences a permis de valider les predictions theoriques et d’acceder aune meilleure comprehension des dynamiques complexes inherentes a la propagation non-lineaired’impulsions optiques.
Technology Studies to Meet the Needs of People With Dementia and Their Caregivers

The aim of this article is to present the findings of a review of studies that focused on technology supporting people with dementia and their caregivers. A literature search was carried out in eight scientific literature databases covering literature published between January 1992 and February 2007. A total of 46 studies providing original data and one review were included in this review. Analyses covered the aims of the studies, the technology used, study design, methods, outcome variables, and results. Most studies were carried out in residential care and focused on the needs of formal caregivers. Only a few studies involved people with dementia actively using the technology. The studies are difficult to compare because of the large variety of aims, technologies, design, and outcome measurements. There is a need for more research in this area, in particular, with people who have a mild stage dementia living in the community.
Appropriate Assessment Strategy for Student Nurses: Practice and Theory?

The study examines student nurse attainment of pass grades at both theoretical and practical level. The rationale for the importance of this research is that it would provide an insight into whether the levels of assessment in the first year are appropriate. This research may also demonstrate whether students are more likely to pass practical assessments assessed by mentors in practice or theoretical assessments marked by academic staff in universities. It is pertinent to re-examine the curriculum and type of assessments that pre-registration student nurses undertake, in light of the recent drive for adding in care and compassion into the nursing curriculum following the Mid-Staffordshire enquiry and the subsequent Frances report. There is evidence which has demonstrated that mentors out in practice rarely fail students in their practical assessments.
Remix : une architecture pour la recherche dans les masses de données indexées

Le projet ReMIX a pour objectif de proposer une architecture materielle destinee a accelerer la recherche d'information dans les masses de donnees. Son coeur est une memoire de tres grande capacite etroitement couplee a des ressources reconfigurables. On peut alors acceder rapidement aux donnees (comparativement a des support de stockage de type disque magnetique) et envisager des strategies de recherche innovantes orientees, notamment, sur l'indexation des donnees. La programamtion du systeme ReMIX est prise en charge par un framework qui guide le concepteur depuis la specification d'une nouvelle application jusqu'a sa mise en oeuvre sur le support reconfigurable. Cet article presente les motivations, l'architecture et l'environnement de programmation du systeme ReMIX.
A Novel Method for Perception and Map Construction of Environment Information Based on Laser Range Finder

A method for perception and map construction of the unknown environmental information is described in this paper by analyzing and processing the data measured by laser range finder (LRF). The structure of the laser range finder, the structure of its returned measurement data, its working principle, and communication protocol are presented. The physical meaning of the data are studied and illustrated as well as its representation methods. The corresponding algorithm routine and the GUI interface program are introduced. Experiments are conducted to verify the range finding accuracy of the sensor and the data visualization method is also introduced. Results indicate that the proposed method is sufficiently valid and can satisfy the desired requirements.
Assessing treatment response in pancreatic cancer: role of different imaging criteria

Poster: "ECR 2017 / C-0634 / Assessing treatment response in pancreatic cancer: role of different imaging criteria" by: "E. Boninsegna1, R. Negrelli1, G. A. Zamboni1, G. Avesani2, R. Manfredi1, R. Pozzi-Mucelli1; 1Verona/IT, 2Bolzano/IT"
Deploying and maintaining a campus grid at Clemson University

Many institutions have all the tools needed to create a local grid that aggregates commodity compute resources into an accessible grid service, while simultaneously maintaining user satisfaction and system security. In this thesis, the author presents a three-tiered strategy used at Clemson University to deploy and maintain a grid infrastructure by making resources available to both local and federated remote users for scientific research. Using this approach virtually no compute cycles are wasted. Usage trends and power consumption statistics collected from the Clemson campus grid are used as a reference for best-practices. The loosely-coupled components that comprise the campus grid work together to form a highly cohesive infrastructure that not only meets the computing needs of local users, but also helps to fill the needs of the scientific community at large. Experience gained from the deployment and management of this system may be adapted to other grid sites, allowing for the development of campus-wide, grid-connected cyberinfrastructures.
Ground presuppositions – presupposizioni di 'fondo': uno sguardo nuovo su un fenomeno classico

Cette these propose que les presuppositions les plus prototypiques sont non pas les 'presuppositions discursives', liees aux declencheurs discursifs (groupes nominaux en position referentielle, phrases clivees, verbes factifs, implicatifs, de jugement, etc.); mais bien les 'presuppositions de base' : a savoir, les distinctions ontologiques entre humains, animaux, vegetaux, concrets, lieux, etc. Les premieres sont 'presuppositions' seulement dans la mesure ou elles ressemblent aux secondes. La these adopte une notion 'fonctionnelle' de presupposition. Les presuppositions discursives remplissent la fonction de presupposition seulement pour un acte de parole contingent ; les presuppositions de base, en revanche, remplissent la fonction de presupposition pour toute notre forme de vie. La difference ne reside pas dans cette fonction, mais bien dans l'ampleur de la pratique par rapport a laquelle elle est remplie.