Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative evaluation of Nickel-Titanium closed coil spring and Elastomeric chain for canine retraction . A Randomized Clinical Trial

Introduction:Preadjusted Edgewise appliance (MBT) has popularized the use of sliding mechanics, which has become the most commonly used method of achieving space closure in orthodontics. In the quest for the most efficient method of delivering constant retractive force to the teeth, NiTi closed coil springs and the elastomeric chains have been the most commonly used modalities. The aim of this investigation was to find out and compare the rate of mandibular canine retraction with NiTi closed coil spring and elastomeric chain delivering 200grams of force with sliding mechanics using preadjusted edgewise appliances. Methods:In this Randomized clinical trial, 30 patients with bimaxillary dentoalveolar protrusion to be treated with 1st premolar extraction and high anteroposterior anchorage requirement, were included. All of them were bonded with 0.022 MBT bracket prescription. After alignment and leveling, each patient was assigned a number,then allocated into a groups with the help of computer-generated random number table. The mandibular canine retraction was started in the two groups with the help of NiTi closed coil spring and Elastomeric chain delivering 200grams of force and at each visit after 4 weeks interval, the force levels were checked and calibrated at every appointment for 3months. Results:A statistically significant difference was seen between the rate of mandibular canine retractionusing NiTi closed coil spring and elastomeric chains. However, the difference seemed to be clinically non-significant. The mean rate of space closure for NiTi closed coil spring and the Elastomeric chain was 1.62±0.14mm/month and 1.33±0.13mm/month respectively. Conclusion:NiTi closed coil spring was found to be more efficient in retracting the mandibular canine, the difference however was clinically non-significant. Additionally, the clinician should take into account the considerable cost factor associated with NiTi closed coil springs. Thus, Elastomeric chains present as a suitable alternative to NiTi coil spring for space closure in sliding mechanics. -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 12-10-2018 Date of acceptance: 27-10-2018 -------------------------------------------------------------------------------------------------------------------------------------
Expression and Clinical Significance of miR-185 in Tissues of Colon Carcinoma

Objective To investigate the expression of the miR-185 in tissue of colon carcinoma and its clinical significance. Methods The tissue specimens and paracancerous tissues of 52 cases were collected and compared.Hybridization in situ was used to detect the miR-185 expiession in those speeimens.Results The positive expression rate of the miR-185 was 13.46%in colon carcinoma which was lower than the control group(84.62%)(P0.01). It suggested that the miR-185 expression was associated with advanced clinical stage and with lymph node metastasis,stageⅢ/Ⅳwere higher thanⅠ/Ⅱtumor(P0.05),tumors with lymph node metastasis were lower than tumors without lymph nixie metastasis in colon carcinoma(P0.01). Conclusions MiR-185 may play an important role in the proliferation,and metastasis of colon carcinoma,and it could he an indicator in the diagnosis and prognosis of colon carcinoma,miR-185 can be used as a predictive biomarker.
Design Considerations for Steel Fiber Reinforced Concrete Reported by ACI Committee 544

D. V. Reddy George C. Hoff Norman M. Hyduk Roop L. Jindal Colin D. Johnston Charles W. Josifek David R. Lankard Brij M. Mago Henry N. Marsh, Jr.* Assir Melamed Nicholas C. Mitchell Henry J. Molloy D. R. Morgan A. E. Naaman Stanley L. Paul+ Seth L. Pearlman V. Ramakrishnan James I. Daniel Secretary Ralph C. Robinson E. K. Schrader* Morris Schupack* Shah Somayaji J. D. Speakman R. N. Swamy Peter C. Tatnall B. L. Tilsen George J. Venta Gary L. Vondran Methi Wecharatana Gilbert R. Williamson+ C. K. Wilson Ronald E. Witthohn George Y. Wu Robert C. Zellers Ronald F. Zollo
COMBINING PROPOFOL AND REMIFENTANIL PHARMACOKINETIC AND PHARMACODYNAMIC MODELS IN THE OPERATING ROOM : AN OBSERVATIONAL STUDY by

Remifentanil and propofol are commonly used together for total intravenous anesthesia. Though their synergistic pharmacodynamic interaction has been characterized with surrogate measures in volunteers, the relationship of these surrogate measures to actual surgical stimuli has not been validated prospectively in the operating room. This study combines a set of propofol and remifentanil pharmacokinetic (PK) and pharmacodynamic (PD) models to estimate their PD interaction and predicts the resulting likelihood of sedation and analgesia intraoperatively. With IRB approval and informed consent, we studied 24 ASA physical status I, II, and III patients scheduled for laproscopic surgery receiving total intravenous anesthesia. Standard anesthetic practice was not altered for this study. Responses and nonresponses to the intraoperative stimuli of laryngoscopy and skin incision were recorded. The predicted effect-site concentrations at these data points, and at the loss and return of responsiveness, were plotted on response-surface models for corresponding surrogate measures determined in volunteers. Patient observations were compared to pharmacodynamic predictions. Methods to reduce differences between the model predictions and observations in the patients are identified and discussed. The results of this study suggest that tracheal intubation, a surgical milestone, is more stimulating than the surrogate measure of laryngoscopy alone. The PK-PD
Demographic , Histopathological Patterns And Clinical Profile of Oral Squamous Cell Carcinoma At A Tertiary Level Referral Hospital In Jharkhand

Oral cancer is one of the most common cancer in India. The aim of this study was to analyze retrospectively the demographic, histopathological and clinical profile of oral squamous cell carcinoma patients who attended a tertiary level care referral hospital in Jharkhand. A total of 324 biopsy proven cases of OSCC were studied. The data was collected for a period of June 2015 to December 2017 . The cases were analyzed in terms of age,gender,duration of symptoms,habits(tobacco and alcohol consumption),site of primary tumour and stage at presentation and the results were formulated to chart the trends. Male to female ratio was 2.48:1. Most of the patients of OSCC belonged to the age group of 51-60 years(26.54%). Buccal mucosa was found to be the most common primary site of involvement. Majority of the patients presented in stage IVA (40.12%). Well differentiated SCC (56.79%)was the most predominant histological variant in this study. This study hence showed that OSCC is very widespread in this region and majority of cases presented at advanced stages due to lack of awareness. Early detection and intervention is required to decrease the morbidity and mortality associated with oral squamous cell carcinoma.
A Compound Poisson-Gamma Trade Model

The paper builds a new statistical model of aggregate trade flows from microfoundations, which can be estimated by maximum likelihood, and is not subject to three important potential biases identified in the literature on gravity equation estimation: sample selection, heteroskedasticity, and heterogeneity bias. The model delivers estimates of the determinants of the intensive and extensive margins of exporting, as well as the number of local and exporting firms, using only aggregate trade flows. The model is tested on simulated data and compares favourably to other widely used estimation techniques.
In-silico study of flavonoids from Cassia tora as potential anti-psoriatic agent

Psoriasis is a skin disease that affect 2-3 % of the world’s population. As a shift from the popular focus on plant fatty acid, fifteen flavonoids from Cassia tora were evaluated in-silico for their ability to bind to fifteen anti-psoriatic targets. It was observed that all the flavonoids made varying degrees of favourable binding interactions with each of the protein targets. London dG scoring method identified that five compounds had higher binding affinity toward TNF-α, BTK, PAD and SPK than their co-crystallized ligands. Twelve of the flavonoids made better binding interactions with AA2R, PK and PKC than their co-crystallized inhibitors whereas all the compounds except 6 had lower free binding energy toward P38MK, IL-17A, PDE-4, CCS and Jak-3 than their native ligands. Only the docking scores of three molecules (1, 2 and 8) ranked lower than the reference ligands of S1PR and Rac1. Moreover, it was noted that only 2 interacted with IL-23 with binding affinity comparable to its native ligand. The docking scores of the studied flavonoids highlight the presence of highly polar group (especially sugar) as a vital structural requirement for strong binding with the target proteins.
MULTI-OBJECTIVE OPTIMIZATION FOR AN ENHANCED MULTI-CORE SNIPER SIMULATOR

In this paper we present a four objectives automatic design space exploration methodology for the Sniper multi-core simulator using our multi-objective optimization tool called FADSE. Our target was to search for the quasi-optimal Pareto CPU microarchitectures which simultaneously optimize the following four objectives: integration area, processing performance, energy consumption and thermal behavior. The temperature metric represents the 4 objective added by us in the automatic optimization process, which provides for sure a more realistic design space exploration. With the proposed improvements we have found, for each of the objectives, better configurations than the original Gainestown 4 cores microarchitecture configuration used by Sniper. Also, the experimental results showed that the automatic optimization in the 4-objectives space provides better Pareto configurations than our previous methodology, working in a 3-objectives space.
Aging of carotid bodies and atherosclerosis of carotid arteries

Background. Carotid arteries supply blood to the carotid bodies, organs that generate respiratory responses to hypoxia. Carotid body parenchyma undergoes degenerative changes with age. The aim of the present study was to investigate the hypothesis that atherosclerosis of the carotid arteries, leading to blood flow obstruction and consequently hypoxia, could underlie age-changes in the carotid bodies. Material and methods. The study was performed on anesthetized rats in two age groups: young — 2 months and old — 24 months of age. Fragments of the carotid body bifurcation were dissected for an ultrastructural evaluation. Resuts. There were only minor changes in the elastin layer of the arterial wall with breaks in this layer continuity, increased number of collagen fibrils, and changed fenotype of smooth muscle cells. Conclusions. Relatively small age-changes in the carotid arteries, which cannot cause blood flow obstruction, do not seem to explain profound degeneration of aged carotid bodies. Age-changes in the carotid bodies may thus reflect a process of true physiological aging. key words: atherosclerosis, carotid artery, carotid body, chemoreceptors Adres do korespondencji: mgr Aneta Dymecka Zakład Neurobiologii Oddychania, Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN ul. Pawińskiego 5, 02–106 Warszawa e-mail: dymeckaa@cmdik.pan. pl tel. /faks: (022) 668 54 16 Wstęp Kłębki szyjne, zlokalizowane w pobliżu rozwidlenia się tętnicy szyjnej wspólnej na tętnicę szyjną zewnętrzną i wewnętrzną, odgrywają kluczową rolę w stymulacji oddychania w odpowiedzi na hipoksję. Stymulację zapoczątkowują komórki chemoreceptorowe kłębków, które są ułożone w „gronka” otoczone tkanką łączną i gęstą siecią naczyń kapilarnych. W badaniach przeprowadzonych na szczurach wykazano, że ultrastruktura kłębków szyjnych wraz z wiekiem ulega zmianom degeneracyjnym [1]. Przyczyna tych zmian pozostaje jednak niejasna. Może ona zależeć od niedotlenienia parenchymy kłębków w wyniku upośledzonego przepływu krwi w naczyniach doprowadzających do nich krew, którymi są tętnice szyjne. Tym bardziej, iż wiadomo, że tętnice te, zwłaszcza rejon rozwidlenia tętnicy szyjnej wspólnej, jest u ludzi szczególnie podatny na zmiany miażdżycowe. Wynika to z szybkości i turbulencji przepływu krwi, co powoduje uszkodzenie komórek śródbłonka [2]. Zmiany w kłębkach mogą też być wyrazem procesu starzenia się organu per se. Celem niniejszej pracy była próba rozróżnienia między tymi dwoma mechanizmami przez porównanie zależnych od wieku zmian w tętnicach szyjnych u szczura. Materiał i metody Badaniem objęto 10 szczurów rasy Wistar, płci męskiej w wieku 2 i 24 miesiące. Zwierzęta poddano narkozie a-chloralozowo-uretanowej podanej dootrzew-
Optimization of the efficiency of search operations in the relational database of radio electronic systems

The increase of interoperability of radio electronic systems used in the Armed Forces requires the processing of very large amounts of data. Requirements for the integration of information from many systems and sensors, including radar recognition, electronic and optical recognition, force to look for more efficient methods to support information retrieval in even-larger database resources. This paper presents the results of research on methods of improving the efficiency of databases using various types of indexes. The data structure indexing technique is a solution used in RDBMS systems (relational database management system). However, the analysis of the performance of indices, the description of potential applications, and in particular the presentation of a specific scale of performance growth for individual indices are limited to few studies in this field. This paper contains analysis of methods affecting the work efficiency of a relational database management system. As a result of the research, a significant increase in the efficiency of operations on data was achieved through the strategy of indexing data structures. The presentation of the research topic discussed in this paper mainly consists of testing the operation of various indexes against the background of different queries and data structures. The conclusions from the conducted experiments allow to assess the effectiveness of the solutions proposed and applied in the research. The results of the research indicate the existence of a real increase in the performance of operations on data using indexation of data structures. In addition, the level of this growth is presented, broken down by index types.
Economic and Environmental Assessment of Extra Virgin Olive Oil Processing Innovations

Economic and Environmental Assessment of Extra Virgin Olive Oil Processing Innovations Anna I. De Luca, Teodora Stillitano, Giacomo Falcone *, Giacomo Squeo, Francesco Caponio, Alfio Strano, Giovanni Gulisano. "Mediterranea" University of Reggio Calabria – Department of Agriculture “AGRARIA”, Feo di Vito 89122 Reggio Calabria Italy Università degli Studi di Bari Aldo Moro Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Via Amendola 165/A – 70126, Bari, Italy giacomo.falcone@unirc.it
Institutional Repository In uence of carbon nanotubes on the rheology and dynamic mechanical properties of polyamide-12 for laser sintering

The rheological behaviour of polymer nanocomposites is very important for polymer processing and understanding the structure-properties relationship. In this paper, the rheological properties of a polyamide 12 (PA12) carbon nanotube (CNT) nanocomposite for laser sintering were studied. Compared to neat PA12, the presence of CNTs resulted in higher storage modulus (G0), loss modulus (G00) and viscosity (h). With an increase in temperature, viscosity showed an unusual increase for both PA12 and the PA12-CNT nanocomposites, which is likely to result from incomplete melting of powder particles. Dynamic mechanical analysis was carried out to examine the effect the CNTs were having on the laser sintered parts. The laser sintered PA12-CNT nanocomposite had an increased elastic modulus compared to that of neat PA12. The CNT and polymer matrix interaction hindered the chain motions, which resulted in higher loss modulus and decreased the thermal expansion coefficient. Crown Copyright 2014 Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
- 1-Assessing the effectiveness of antimicrobial agents infused in polyurethane composite rubber flooring products in the control of bacterial pathogens

The viability of nosocomial and community-acquired bacterial pathogens was assessed on polyurethane composite rubber flooring products containing three different antimicrobial agents. Samples containing three concentrations of zinc pyrithione, N-butyl-1,2-benzisothiazolin-3-one, or inorganic silver-glass zeolite were tested in three separate assays using gram (+) and gram (-) bacterial species. A direct contact assay (JISZ 2801) was optimized to mimic real-world conditions and a time-course study revealed that zinc pyrithione incorporated into the polyurethane moisture cure adhesive used as a binder for the rubber flooring composition was effective at inhibiting bacterial growth, including communityand hospital-acquired methicillin resistant Staphylococcus aureus (MRSA) strains. MRSA strains isolated from rubber flooring at a local exercise facility were found to exhibit differential sensitivity to antimicrobial agents, demonstrating that levels of inhibition can vary substantially depending on the strain used. Other factors affecting sensitivity to the antimicrobial agents include metabolites in the incubation solution, incubation temperature, and age of rubber sample or the extent they have been washed. Results suggest that the inclusion of zinc pyrithione based antimicrobial agents in polyurethane composite rubber flooring products can effectively inhibit the growth of pathogenic bacteria commonly encountered in gymnasiums or other public environments that utilize resilient rubber flooring products. Approaches to maximize the level of control will be discussed, as well as areas of future research.
Novel orodispersible compositions of nutraceuticals prepared by the technology of extrusion-spheronization

Article history: Received on: 18/12/2016 Accepted on: 12/02/2017 Available online: 30/04/2017 European Medicines Agency (EMA) characterized liquid formulations as most appropriate for pediatric population but this includes drawbacks of lesser stability, more shelf space and dosing error in comparison to solid oral dosage forms. Orodispersible systems hold great promise for children as they are easy to administer, do not require additional water, are difficult to spit out, stable, thus combining advantages of solid and liquid oral dosage forms. The aim of the present research was development of orodispersible pellets of Calcium and Cholecalciferol, as nutraceuticals using the technology of Extrusion – Spheronization. Calcium deficiency is manifested in the bones and teeth of all young animal species, including humans. Effects include stunted growth, poor quality bones and teeth, bone malformation. The experimental work included optimization of the extrusion – spheronization processing parameters and choice of excipients, which critically affected the product quality to produce orodispersible pellets. The developed orodispersible pellets had satisfactory quality control parameters and formed soft palatable mass on contact with salivary fluid which could be easily swallowed. The in vitro dissolution studies indicated rapid release of active and the pellets were found to be stable. An additional advantage of these orodispersible pellets is sprinkling over soft food, juices etc for food fortification prior to administration.
INVESTIGATION OF STRUCTURAL AND ELECTRICAL PROPERTIES OF Ce 3 + IONS SUBSTITUTED Cd-Co FERRITES

a Department of Physics, Government College University, Faisalabad 38000, Pakistan b Department of Physics, Bahauddin, Zakariya University Multan, 60800, Pakistan c Department of Physics, The University of Lahore, 1-kM Raiwind Road, Lahore, Pakistan d Cardiovascular and Metabolic Research Unit, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, Canada e Department of Physics, COMSATS University, Islamabad, Lahore Campus,54500 Lahore, Pakistan
Research on Addiction Quarterly Journal of Drug Abuse

Objective: This study was an attempt to investigate the effect of music therapy on addicts’ state-trait anxiety rate in the stage of drug-free rehabilitation. Method: A quasiexperimental research design, along with pretest-posttest and control group was employed for the conduct of this study. The statistical population of the study included the addicts in the rehabilitation stage who had referred to the Clean Collaborators Rehabilitation Camp in Ardebil Province in November 2014. From this population, the number of 32 addicts in 16-50-year-old age range was selected as the participants of the study by convenience sampling method. State-Trait Anxiety Inventory was used for data collection. Results: The results of multivariate covariant analysis showed that there is a significant difference between control and experimental groups in state and trait anxiety. In other words, the state and trait anxiety of addicts in the experimental group had been reduced after music therapy. Conclusion: Considering the obtained results, it can be concluded that music therapy alone or along with other psychological interventions can be an effective method for reducing addicts’ anxiety in drug-free rehabilitation stage.
Extensional-flow theory with application to fibre drawing .

Extensional or elongational flows are most commonly associated with the study of rheology following the work of Trouton (1906). In this paper we outline an asymptotic method for the derivation of an extensional-flow model for the drawing of fibres. We obtain ODEs describing the change in area of the cross-section and the temperature from preform to fibre. In general, these are coupled with a 2D transverse-flow problem describing the evolution of the geometry in the cross-section due to surface tension and pressure. The accuracy of the model is demonstrated by comparison with experiments and finiteelement simulations, and its computational efficiency is briefly discussed. Models may be obtained for other extensional flows using similar methods. Introduction Honey dripping from a spoon is an extensional (or elongational) flow; gravity causes the fluid to stretch. Such flows are ubiquitous in nature and industry and include fibre drawing (or spinning), the float glass process used for making sheet glass, and a spider spinning a web. Extensional flows are also used in rheometry to measure the extensional viscosity of liquids. Trouton is the father of extensional rheometry, publishing in 1906 [18] two theoretical explanations and results from experiments (including application of a tensile force to a rod of viscous fluid and gravitational spinning of a fluid thread) which showed the extensional viscosity of a Newtonian fluid to be three times its shear viscosity. Today the extensional viscosity for a Newtonian fluid is often called the Trouton viscosity and the ratio of the extensional and shear viscosities is called the Trouton ratio. The Trouton ratio is readily derived by considering, as did Trouton [18], the elongation of a uniform cylinder of (essentially) incompressible isotropic viscous fluid, assuming the rate of elongational strain to be uniform in any cross-section. Concurrently with elongation at rate e it must contract at rate e/2 in the transverse directions. Setting x to be the axis along which elongation occurs, and y and z to be the transverse directions, the rate-ofstrain tensor is