Miracle-dz/UniFAR-FTUs huggingface dataset:
Heart rate and heart rate variability response to the transpiration of vortex-water by Begonia Eliator plants to the air in an office during visual display terminal work.

OBJECTIVES This study explores the effects of vortex-water transpired from indoor greenery to office air, in relation to heart rate and heart rate variability during exposure to an electromagnetic field (EMF) from a visual display terminal (VDT). DESIGN The study followed a randomized prospective single group cross-over design. SUBJECTS Fifty (50) healthy volunteers, seated in any ordinary working posture in front of a VDT. INTERVENTION Electrocardiography was measured in five 10-minute sequential tests. The VDT was turned off during the first test and switched on for the subsequent four tests. During tests 3 and 4, one of two Begonia Eliator plants, irrigated with either tap water or vortex-rotated (active) tap water during growth, was placed adjacent to the VDT. Heart rate, heart rate variability (HRV) and power spectral density (PSD) were analyzed. RESULTS The heart rate was unchanged at the start of EMF exposure. The time domain measurements indicated a significant decrease in heart rate and a significant increase in HRV, accompanied by higher vagal tone in the presence, and finally in the absence, of the active plant. PSD parameters revealed significantly higher total power, as well as an increase in low frequencies (LF) and high frequencies (HF) in the condition induced by the active plant as well as after its removal. Very low frequencies (VLF) increased at EMF exposure whereas normally HF power decreased, accompanied by a rise in LF power and LF/HF ratio. HF power was higher at exposure to the active compared to the control plant. Spectral power density diagrams revealed an intensified spectral power band at frequencies of around 0.1 Hz at the condition of both plants, indicating systemic autonomic stability. CONCLUSIONS The findings suggest that the parasympathetic response was associated with reduced heart rate, implicating restoration and maintenance of metabolic energy resources mediated by an involuntary adaptation to active plant-related stimuli.
Myogenic changes of the levator ani muscle in premenopausal women: The impact of vaginal delivery and age

The aim of this study was to evaluate the impact of parity and age on histomorphology of the pelvic floor muscles in female cadavers of reproductive age and to find out whether there is evidence of myogenic or neurogenic muscle injury. In a cross‐sectional study 45 premenopausal unfixed and fresh female cadavers were studied. Four groups were defined: nulliparous and parous women under the age of 40 and over 40 years of age. The pelvic floor was biopsied at six standardized locations. For evaluation of the quantitative parameters and fiber type identification, actomyosin ATPase at pH 9.4 was used. For histomorphological evaluation, sections were stained with hematoxylin/eosin, van Gieson, and Gomori trichrome. The circumference of type I fibers is significantly larger in nulliparous women younger than 40 years compared to nulliparae older than 40 years. Comparing these groups, the form factor of type II fibers also increases significantly, presenting a more circular cell form. Compared to nulliparae, vaginal delivery led to a significant difference regarding the presence of centrally located nuclei, fibrosis, and variation in fiber diameter. In nulliparous women, these significant changes were also found with increasing age. In women with a history of vaginal delivery, no further increase in these characteristics could be detected with increasing age. Comparing the three different biopsy sites, all three changes were more pronounced in the ventral part. There was no evidence of grouped fiber atrophy, small angulated fibers, or type grouping in any of the biopsy specimens. Aging and vaginal childbirth lead to histomorphological changes of the pelvic floor muscle that are consistent with changes of myogenic origin. Evidence of neurogenic damage could not be demonstrated. Neurourol. Urodynam. 17:197–205, 1998. © 1998 Wiley‐Liss, Inc.
A Scalable Bloom Filter Based Prefilter and Hardware-Oriented Predispatcher

Presented in this paper a scalable bloom filter based prefilter and a hardware-oriented predispatcher pattern matching mechanism for content filtering applications, which are scalable in terms of speed, the number of patterns and the pattern length. Prefilter algorithm is based on a memory efficient multi-hashing data structure called bloom filter. According to the statistics of simulations, the filter ratio can reach up to 60% if the whole engine has been trained well. It has been showed that this engine could enhance the capabilities of general-purpose IDS solutions.
Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults.

BACKGROUND Obesity and type 2 diabetes are well-known risk factors for the development of nonalcoholic fatty liver disease (NAFLD). However, NAFLD is not rare in nonobese, nondiabetic adults. The aim of this study was to evaluate the metabolic significance of NAFLD in nonobese, nondiabetic adults. METHODS This study examined 768 nonobese (body mass index [BMI] [calculated as weight in kilograms divided by the square of height in meters], > or =18.5 and <30) (460 normal-weight and 308 overweight subjects), nondiabetic individuals older than 30 years who participated in a medical checkup. All the subjects had negative serologic findings for hepatitis B and C viruses and had an alcohol intake less than 140 g/wk. A standard interview, anthropometrics, a biochemical study, and abdominal ultrasonography were conducted. RESULTS The prevalence of NAFLD in the enrolled subjects was 23.4%. In the normal-weight (BMI, > or =18.5 and <25) and overweight (BMI, > or =25 and <30) groups, NAFLD was a significant predictor of insulin resistance and other metabolic disorders, including hypertriglyceridemia and hyperuricemia. The odds ratio of the metabolic disorders in subjects with NAFLD compared with those without NAFLD in the normal-weight group was higher than that in the overweight group. Multiple logistic regression analysis showed that sex, waist circumference, triglyceride level, and insulin resistance were independently associated with NAFLD in the normal-weight group. CONCLUSIONS Nonalcoholic fatty liver disease is closely associated with metabolic disorders, even in nonobese, nondiabetic subjects. Nonalcoholic fatty liver disease can be considered an early predictor of metabolic disorders, particularly in the normal-weight population.
Associations between diet and (in)activity behaviours with overweight and obesity among 10–18-year-old Czech Republic adolescents

Abstract Objectives To assess the prevalence of normal weight, overweight and obesity among 10–18-year-old Czech Republic adolescents and to assess the association between energy balance-related behaviours and overweight/obesity. Design Cross-sectional data from ‘The 6th Nation-wide Anthropological Survey of Children and Adolescents 2001 Czech Republic’ have been used. Setting Height and weight were objectively measured. Data on adolescents’ behaviours were assessed with self-reported questionnaires. Background variables were assessed by means of a parental questionnaire. Multi-level logistic regression analyses were conducted to assess behavioural risk factors of being overweight/obese. Subjects Data on 31 228 adolescents aged 10–18 years were included in the present study. Results The highest prevalence of being overweight or obese was found among boys and younger adolescents. Boys were more physically active, watched more television (TV) and used the computer more often than did girls. Being on a diet and skipping meals were positively associated with being overweight/obese, independent of gender. In boys (10–14 years old), inverse associations with being overweight/obese were found when being more physically active. Monitoring weight showed inverse relations with being overweight/obese in 15–18-year-old girls. Watching TV more than 7 h a week was positively associated with being overweight/obese in 15–18-year-old girls, and was found to be negatively associated in boys of the same age group. Conclusions These behaviours should be targeted when preventing overweight and obesity among Czech Republic adolescents. Studies using better measures of energy balance-related behaviours are needed.
Proximitäts- und Aktivitätserkennung mit mobilen Endgeräten

Mit der immer groseren Verbreitung mobiler Endgerate wie Smartphones und Tablets aber auch am Korper getragener Technik (Wearables), ist die Vision einer ubiquitar von Computern durchzogenen Welt weitgehend Realitat geworden. Auf Basis dieser uberall verfugbaren Technologien lassen sich mehr und mehr kontextbezogene Anwendungen umsetzen, also solche, die ihre Diensterbringung an die aktuelle Situation des Benutzers anpassen. Ein wesentliches Kontextelement ist dabei die Proximitat (Nahe) eines Benutzers zu anderen Benutzern oder Objekten. Dabei ist diese Proximitat nicht nur rein ortlich zu verstehen, sondern ihre Bedeutung kann auf samtliche Kontextelemente ausgedehnt werden. Insbesondere ist auch die Ubereinstimmung von Aktivitaten verschiedener Benutzer von Interesse, um deren Zusammengehorigkeit abzuleiten. Es existiert gerade im Hinblick auf ortliche Nahe eine Reihe von Standardtechnologien, die eine Proximitatserkennung grundsatzlich erlauben. Alle diese Verfahren weisen jedoch deutliche Schwachen im Hinblick auf Sicherheit und Privatsphare der Nutzer auf. Im Rahmen dieser Arbeit werden drei neue Verfahren zur Proximitatserkennung vorgestellt. Dabei spielen die Komponenten "Ort" und "Aktivitat" jeweils in unterschiedlichem Mase ein wichtige Rolle. Das erste Verfahren benutzt WLAN-Signale aus der Umgebung, um sichere, d.h. unfalschbare, Location Tags zu generieren, mit denen ein privatsphare-schonender Proximitatstest durchgefuhrt werden kann. Wahrend das erste Verfahren rein auf ortliche Nahe abzielt, berucksichtigt das zweite Verfahren implizit auch die Aktivitat der betrachteten Benutzer. Der Ansatz basiert auf der Auswertung und dem Vergleich visueller Daten, die von am Korper getragenen Kameras aufgenommen werden konnen. Die Grundidee des dritten Verfahrens besteht darin, dass auch rein auf Basis von Aktivitaten bzw. Aktivitatssequenzen eine kontextuelle Proximitat zwischen verschiedenen Nutzern festgestellt werden kann. Zur Umsetzung dieser Idee ist eine sehr feingranulare Aktivitatserkennung notwendig, deren Machbarkeit in dieser Arbeit ebenfalls gezeigt wird. Zusammengenommen werden in der vorliegenden Arbeit mehrere Wege aufgezeigt, unterschiedliche Arten von kontextueller Proximitat auf sichere und privatsphare-schutzende Weise festzustellen.
Double-blind randomized controlled trial to determine extent of amnesia with midazolam given immediately before general anaesthesia.

BACKGROUND Anterograde, but not retrograde, amnesia has been demonstrated following midazolam administration. However, there have been no studies investigating whether or not immediate retrograde amnesia can be produced with midazolam. METHODS After ethics committee approval and consent, 40 adult patients undergoing surgery and general anaesthesia were randomly allocated to one of four groups: midazolam 2 mg, midazolam 5 mg, midazolam 10 mg or control (normal saline). Measurements were made from 12 min prior to induction of anaesthesia, and the study drug was administered 8 min prior to induction of anaesthesia. Midazolam effects were measured using visual recognition of posters, recall of specific events, bispectral index (BIS) and sedation visual analogue score. RESULTS Recognition and recall rates were similar between groups up until the time of study drug administration, with no evidence of retrograde amnesia (all P>0.3). There was a dose-dependent deterioration in visual recall (P=0.002), event recollection (P<0.001), BIS (P<0.001) and sedation score (P<0.001) following i.v. midazolam when compared with control. CONCLUSIONS We found no evidence that i.v. midazolam 2-10 mg produces immediate retrograde amnesia. Midazolam causes anterograde amnesia in a dose-responsive manner.
De la Unión Bancaria a la Unión de Mercado de Capitales

La finalidad del articulo es analizar los objetivos, y avances realizados hasta la fecha por la Union de Mercado de Capitales en Europa (UMC), identificando las diferencias y complementariedades con la Union Bancaria (UB). En este sentido, aunque la formulacion mas concreta del objetivo fundacional de la UMC era «desbancarizar Europa», no cabe duda de que existen importantes complementariedades entre la financiacion que proveen los bancos y la obtenida a traves de los mercados de capitales, siendo esta especialmente apropiada para empresas con marcado caracter innovador y un alto potencial de crecimiento.
Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice.

N-acetylcysteine is the drug of choice for the treatment of acetaminophen poisoning, yet the mechanism of protection in vivo is unknown. Prevention of liver injury could result from decreased production of the toxic intermediate(s), from increased capacity to detoxify the toxic intermediate(s) or from increased ability of the tissue to withstand or even repair the molecular damage caused by the toxic species. Treatment of mice with N-acetylcysteine (1200 mg/kg p.o.) was found to prevent the hepatic damage caused by 1000 mg/kg p.o. of acetaminophen. Possible mechanisms for this hepatoprotective effect were examined by measurement at different time points of acetaminophen and its metabolites in plasma, urine, bile and whole-body homogenates and by evaluation of the changes in these parameters caused by treatment with N-acetylcysteine. A high-pressure liquid chromatographic method was developed to measure the majority urinary metabolites of acetaminophen and was validated by desorption chemical ionization mass spectral analysis of individual metabolites. Minimal differences in the concentration of unchanged acetaminophen and metabolites in whole-body homogenates at 4, 6 and 24 hr postdose were noted for N-acetylcysteine-treated vs. vehicle-treated mice. These results are incompatible with a decreased formation of the toxic species secondary to delayed acetaminophen absorption from the gastrointestinal tract or with an increased clearance of acetaminophen via nontoxic pathways such as sulfation as plausible mechanisms for the observed hepatoprotection. (ABSTRACT TRUNCATED AT 250 WORDS)
Two cases of acute dexmedetomidine withdrawal syndrome following prolonged infusion in the intensive care unit

Prolonged infusion of dexmedetomidine, an α2-adrenoreceptor agonist anesthetic used in the intensive care unit, produces a withdrawal syndrome of sympathetic over-activity, characterized by tachycardia, hypertension and agitation, but there is no recommended standard treatment for this syndrome. We describe two patients with a clinical diagnosis of acute dexmedetomidine withdrawal and its management with oral clonidine. We utilized the principle of managing acute drug withdrawal with longer acting medications. These two cases demonstrated the benefit of using oral, longer acting clonidine to manage acute withdrawal from shorter-acting, intravenous dexmedetomidine.
Security analysis and the improvement of the sequential multi-signature scheme based on discrete logarithm

In this paper, a class of sequential multi-proxy signature schemes are attacked. It includes existential forgery attack. The scheme has many shortcomings. A new enhanced and can resist forgery attack sequential multi signature scheme is proposed, which based on the improved of the original scheme. The new scheme improved the parameters of the original scheme, improved parameter improve the shortcomings of the scheme, which set reasonable, it is correct.
Efficient Cluster-based Routing Protocol for Wireless Sensor Networks with Mobile Sink using CRSSI

Recent advancement in wireless sensor networks are used in various applications like space exploration, habitat monitoring, and medical treatment target tracking, military surveillance, environmental monitoring, etc. Wireless sensor networks consist of various nodes which contains limited power source, therefore the energy and the lifetime of each wireless sensor nodes must be utilized efficiently. In cluster-based routing protocols with movable sink, routing depends on the cluster head (CH), the traditional schemes of CH selection depend on the residual energy of the node with random cluster head selection. In our view the previous schemes are not an efficient methodology to achieve the energy efficiency and improve the life time of the wireless sensor nodes, because the random cluster head selection with one or two metrics is not an efficient scheme to achieve the high energy efficiency and improve the lifetime of the wireless sensor nodes, with mobile sink. Most optimal solution for the above challenge is cluster based routing protocol with efficient cluster head (CH) selection and cluster-based routing scheme for mobile sink with cluster received signal strength indicator (CRSSI). The simulation results show that the CRSSI scheme achieves high energy efficiency 9.1 % over PI (perpendicular intersection) and 9.8 % over LEACH (low energy adaptive clustering hierarchy), improved life time of the nodes (10 % over PI and 16 % over LEACH) and high packet delivery ratio (19.7 % over PI and 26 % over LEACH). This is achieved through an efficient CH and an efficient cluster-based routing with three metrics, the residual energy of the node, position of sensor node and the transmission and reception count of the node and all these metrics values received through cluster received signal strength indicator (CRSSI). The proposed scheme CRSSI evaluates the performance in different scenarios in terms of energy efficiency, life time of the nodes and packet delivery ratios and performs better compare to PI and LEACH protocols.
An all-digital on-chip clock generator using relative reference modeling

An all-digital on-chip clock generator is proposed in this paper. It features the tolerance of process, voltage and temperature variation according to the special algorithm. The clock generator depends on CMOS standard delay cell without any external clock source, and the periods of CMOS standard delay cell are calculated by the linear polynomial fitting. The proposed on-chip clock generator has been implemented in 180 nm CMOS. The output clock is 10MHz~40MHz adjustable, and tolerates the process, voltage and temperature variation. The frequency error is less than 2.9% with 1.6V-1.8V supply voltage and 0°C-80°C temperature variation. The phase noise is -116.44 dBc/Hz @ 25 MHz offset.
Failure to Suppress Plasma Glucagon Concentrations by Orally Administered Glucose in Diabetic Patients After Treatment

Plasma glucagon response to glucose in diabetic subjects was observed before and after treatment. In normal subjects, plasma glucagon concentrations decreased substantially after an oral glucose load. In all diabetic patients before treatment, plasma glucagon was not suppressed and rather tended to rise paradoxically despite pronounced hyperglycemia. In diabetics treated with sulfonylurea or insulin, basal plasma glucagon concentrations were significantly lower than those in patients who were not treated. However, plasma glucagon response to an oral glucose load was not normalized by successful treatment with sulfonylurea or insulin, in spite of improvement of glucose tolerance. These results suggest that the insensitivity of the A-cell to hyperglycemia exists after treatment, and this abnormal plasma glucagon response to glucose after treatment may be caused either by impaired response of endogenous insulin to glucose, which is sustained even after treatment, or by an intrinsic defect of the A-cell.
Human dermal fibroblast subpopulations; differential interactions with vascular endothelial cells in coculture: Nonsoluble factors in the extracellular matrix influence interactions

The superficial dermis of adult human skin contains a complex arcading microvasculature that provides nutrient support to the overlying epidermis. We propose that the unique subpopulations of dermal fibroblasts located in the superficial dermis contribute to the organization and maintenance of this elaborate microvasculature. This possibility was tested in a coculture system in which distinct subpopulations of adult human dermal fibroblasts were grown to form high‐density lawns that were then seeded with human umbilical vein vascular endothelial cells (EC). The fibroblast subpopulation cultured specifically from the papillary dermis supported a robust array of highly branched tube‐like structures. In contrast, fibroblasts cultured from the reticular dermis provided an anemic level of support for the formation of tube‐like structures. These varied interactions with vascular EC were not due to the differential production of the potent pro‐angiogenic factors vascular endothelial growth factor‐A or fibroblast growth factor‐2. Instead, the extracellular matrix and/or molecules bound to this matrix appeared to contain instructions that modulated these differential fibroblast–vascular EC interactions. One matrix‐binding growth factor, hepatocyte growth factor/scatter factor, was identified that was both differentially expressed by papillary and reticular dermal fibroblasts and which was shown to be physiologically relevant in the coculture model. These studies highlight the importance of fibroblasts in supporting and maintaining vascular integrity. Furthermore, these studies have important implications for wound repair and may help to explain how fibroblasts contribute to the etiology of nonhealing wounds.
Some characteristics of heavy and light bands of Rickettsia prowazekii on Renografin gradients

Suspensions of partially purified Rickettsia prowazekii yielded two bands of organisms when centrifuged to equilibrium in Renografin density gradients. Rickettsiae from the lower, heavy band were defective in their infective and metabolic activities, as compared to organisms from the light band. The greater density in Renografin of heavy-banding organisms was due to their lack of permeability barrier to it, as evidenced by the absence of plasmolysis in hypertonic Renografin. In contrast, light-banding rickettsiae were able to exclude Renografin, since they were plasmolyzed in it. The proportion of heavy-banding organisms in a rickettsial suspension was influenced by the growth phase they were in when harvested from infected yolk sacs, as well as by the conditions and media to which they subsequently were exposed. We have concluded that these defective forms arise from the degeneration of light-banding rickettsiae. This separation of two functional classes of rickettsiae in Renografin density gradients has been exploited (i) to increase the uniformity of the suspensions by removing many noninfectious particles and (ii) to determine rapidly the integrity of certain properties of the cytoplasmic membrane of organisms exposed to a variety of conditions.
Astrocytes as support for axonal regeneration in the central nervous system of mammals

Reactive astrocytes are one of the main impediments for axonal regeneration in the central nervous system of mammals. Using mice KO for GFAP and vimentin, we show that reinnervation occurs after an hemisection of the spinal cord, mainly through sprouting of controlateral intact serotoninergic and cortico‐spinal axons, thanks to the absence of glial reactivity. This reinnervation is paralleled by the restoration of impaired locomotion of the ipselateral hindleg. Future applications to spinal cord injured patients are discussed. GLIA 43:91–93, 2003. © 2003 Wiley‐Liss, Inc.