Miracle-dz/UniFAR-FTUs huggingface dataset:
Variables Related to Organizational Commitment in Health Professionals

Three measures of organizational commitment were related to scores from the Multidimensional Job Satisfaction Scale in a sample of 1121 health professionals to ascertain the organizational factors which were associated with commitment. Opportunity for personal growth or self-actualization and physical working conditions were related to all three forms of commitment. Affective and Normative Commitment were also enhanced in organizations with promotion systems perceived as fair. Organizational groups which also had satisfactory pay scales and supervisors perceived as possessing positive job-related skills had enhanced Affective Commitment; the presence of coworkers with positive attributes was related to Normative Commitment and high opportunities for promotion to Continuance Commitment.
How can Apache help to teach and learn automatic control?

Searching for examples to encourage and motivate students in a subject is not a trivial task. Future Computer Science and Telecommunications Engineers tend to look at Automatic Control reluctantly. They do not relate their working life to it. But, if we blend examples from two areas: telecommunications and control, maybe we can change their minds. These engineers work with web servers: systems that deal with a lot of requests and must give fast and reliable service to users. CPU and memory usage could improve their performance if automatic control techniques are applied. Apache is one of the most well known web servers and it is at this point where Apache can help us.
Risperidone implicated in the onset of tardive dyskinesia in a young woman

The aim of this case report is to highlight that risperidone may cause and ameliorate tardive dyskinesia. A 16 year old white women with a 12 month history of schizophrenia, developed buccolingual masticatory tardive dyskinesia after receiving risperidone 6 mg. She had received small dosages of typical antipsychotics before and during receiving risperidone for short periods. Recommencement of risperidone with 2 mg and increasing to 6 mg resulted in improvement in tardive dyskinesia and up until now she remains free of any abnormal involuntary movements.
No-carrier-added 123I-MIBG: An initial clinical study in patients with phaeochromocytoma

Radioiodinated meta-iodobenzylguanidine (MIBG) is used routinely for imaging and targeted radiotherapy of tumours derived from the neural crest. Since active uptake of MIBG by the noradrenaline transporter (NAT) makes a greater contribution to total drug accumulation than passive uptake when MIBG is present at low concentrations, tumour-specific uptake should be enhanced by the administration of lower molar amounts of MIBG. This could be achieved through the use of MIBG with a high specific activity. Commercially available preparations of 123I-MIBG have specific activities of approximately 200 MBq·mg−1. We have synthesized and used no-carrier-added (n.c.a.) 123I-MIBG produced by an iododesilylation reaction (specific activity 0.7 TBq·mg−1). We report here the first clinical studies comparing the commercially available and n.c. a. MIBG diagnostic preparations. Five patients with known phaeochromocytoma were studied. Unlike studies in animal models, no consistent improvement in tumour uptake was observed with the n.c. a. material. A larger patient group is required to determine whether there are significant differences between the two preparations, before proceeding to studies at therapeutic activity levels of n.c. a. 131I-MIBG. Even with no improvement in tumour uptake, n.c. a. MIBG may be the favoured formulation for therapeutic applications to reduce the molar amount of drug injected.
Symmetry and Synchrony in Coupled Cell Networks 3 Exotic Patterns

This paper continues the study of patterns of synchrony (equivalently, balanced colorings or flow-invariant subspaces) in symmetric coupled cell networks, and their relation to fixed-point spaces of subgroups of the symmetry group. Our aim is to provide a group-theoretic explanation of the "exotic" balanced coloring previously discussed in Part 2. Here we show that the pattern can be obtained as a projection into two dimensions of a fixed-point pattern in a three-dimensional lattice. We prove a general theorem giving sufficient conditions for such a construction to lead to a balanced coloring, for an arbitrary direct product of group networks.
Transcription Factor Binding Sites – Model Comparison and Site Discovery by Correlation with Gene Expression

This thesis concerns transcription factor proteins and statistical analysis of their binding sites in the DNA sequence. We use the REDUCE method, which finds binding sites by using the sites’ correlation with gene expression data from microarray experiment to select potential candidates. We apply REDUCE on the human genome to discover binding sites to transcription factors that discriminate between different NCI-60 cancer cell lines. Different types of models used for representing the binding sites are also compared, and we especially focus on the newly introduced QPMEME method, which is a biophysical approach for estimating the binding free energy between the proteins and the DNA sequence. The QPMEME method represents the binding sites as energy matrices and is similar to the Support Vector Machines method for pattern recognition. A novel measure for comparing binding site models is introduced, where the discovered binding sites’ correlation with gene expression is used as a proxy for the models’ biological significance. We compare the energy matrix model to the widely used weight matrix model, comparing their correlation with the expression levels during the cell cycle of the yeast Saccharomyces Cerevisiae. Bindningsställen till transkriptionsfaktorer jämförelse av modeller och upptäckt av bindningställen genom korrelation med genuttryck
Staphylococcus aureus SaeR/S‐regulated factors reduce human neutrophil reactive oxygen species production

Neutrophils are the first line of defense after a pathogen has breached the epithelial barriers, and unimpaired neutrophil functions are essential to clear infections. Staphylococcus aureus is a prevalent human pathogen that is able to withstand neutrophil killing, yet the mechanisms used by S. aureus to inhibit neutrophil clearance remain incompletely defined. The production of reactive oxygen species (ROS) is a vital neutrophil antimicrobial mechanism. Herein, we test the hypothesis that S. aureus uses the SaeR/S two‐component gene regulatory system to produce virulence factors that reduce neutrophil ROS production. With the use of ROS probes, the temporal and overall production of neutrophil ROS was assessed during exposure to the clinically relevant S. aureus USA300 (strain LAC) and its isogenic mutant LACΔsaeR/S. Our results demonstrated that SaeR/S‐regulated factors do not inhibit neutrophil superoxide (O2−) production. However, subsequent neutrophil ROS production was significantly reduced during exposure to LAC compared with LACΔsaeR/S. In addition, neutrophil H2O2 production was reduced significantly by SaeR/S‐regulated factors by a mechanism independent of catalase. Consequently, the reduction in neutrophil H2O2 resulted in decreased production of the highly antimicrobial agent hypochlorous acid/hypochlorite anion (HOCl/−OCl). These findings suggest a new evasion strategy used by S. aureus to diminish a vital neutrophil antimicrobial mechanism.
Functionality and reliability of resistive RAM (RRAM) for non-volatile memory applications

Various RRAM concepts are currently being investigated (Oxide based RAM, Conductive Bridge RAM), all showing pros and cons depending on the architecture and memory stack. As the specifications are strongly application-dependent, it is likely that the RRAM technology will be bound to a specific market segment. In this paper, we discuss the potential of RRAM for non-volatile memory applications, among them: storage class memory, embedded memory, programmable logic, mass storage and neuromorphic applications. By means of experimental studies and simulations, we analyze the role of the integrated materials on the memory performances and reliability and try to propose optimized stacks suitable for each targeted application.
High gain boost converter with quasi-resonant switched capacitor and coupled inductor

This paper presents a new cascade boost converter topology composed of a zero-current switching switched-capacitor (ZCS SC) quasi-resonant (QR) converter and a coupled inductor conversion scheme. A front ZCS SC converter is proposed to improve the current stress problem during power flow control processing. It is able to provide a high voltage conversion ratio using a set of switched-capacitors with a small series connected resonant inductor for obtaining ZCS switching. The converter operating principle of the proposed conversion scheme is described in detail circuit model analysis. Simulations and experimental results are carried out to verify the performance of the proposed high voltage gain converter.
Survival after recurrence of medulloblastoma in the contemporary era.

2068 Background: Greater than 70% of patients diagnosed with medulloblastoma today are cured. However, salvage therapy after recurrence remains widely varied. Survival after recurrence of medulloblastoma has not been reported in an unselected cohort of patients in the contemporary era. METHODS With approval of the Institutional Review Board, medical records were reviewed for 55 patients diagnosed with medulloblastoma between 2000 and 2010, and treated at Seattle Children's Hospital, the largest pediatric cancer center in the Pacific Northwest, with referrals from Washington, Alaska, Montana, Idaho and Wyoming. Forty-seven children over the age of three at initial diagnosis were considered for this analysis. The following variables were collected for patients diagnosed with recurrent or progressive disease: age at diagnosis, gender, stage, histology, time to relapse, site of relapse, treatment after relapse, and time to death or last contact. Survival was described according to the method of Kaplan and Meier and comparisons were made using the log rank test. RESULTS Fourteen of 47 patients (30%) experienced recurrent or progressive medulloblastoma. The median age at diagnosis was 9 years (range 5.8 to 15.9), and 71% (n=10) were male. Most patients had localized disease (M0, 78.6%), classic histology (78.6%) and gross total resection (92.9%) at initial diagnosis. The median time from diagnosis to recurrence was 18.0 months (range 3.6 - 62.6), and site of recurrence was metastatic in 86% (n=12). The median survival after relapse was 6.8 months (range 0.7 - 77.9); 3-year survival after relapse was 19%. There were trend associations between longer survival and having received additional chemotherapy (median survival 6.8 vs. 1.3 months, p = 0.06) and radiation therapy (15.4 vs. 4.4 months, p=0.13), but not research therapy (2.8 vs. 10.3 months, p =0.69.) Conclusions: Recurrence of medulloblastoma is much more likely to be metastatic than reported in previous eras. Within the limits of our small sample, our data suggest a potential survival benefit from re-treatment with cytotoxic chemotherapy and radiation even in heavily pre-treated patients. This report serves as a baseline against which to evaluate novel therapy combinations.
Effect of Preoperative Deformity on Arthroscopic and Open Ankle Fusion Outcomes

Introduction: Coronal deformity is considered a relative contraindication for arthroscopic ankle fusion. This study assessed whether preoperative coronal ankle joint deformity influenced the outcome of arthroscopic ankle fusion. Methods: Ninety-seven patients had 62 arthroscopic and 35 open ankle fusions between 2005 and 2012. Clinical outcomes were prospectively recorded with use of the Ankle Osteoarthritis Scale (AOS) and Ankle Arthritis Scale (AAS) preoperatively and at 6, 12, and 24 months and final follow-up. Radiological alignment was measured using the tibiotalar angle, the tibial plafond angle, the lateral talar station, and the lateral tibiotalar angle. Both groups had the same demographics. Results: Preoperative deformity was the same regarding sagittal alignment and overall coronal alignment, but the arthroscopic group had less tibial deformity (tibial plafond angle range 0-19 degrees vs 0-43 degrees). At final follow-up, the mean AOS was 34.2 for arthroscopic (95% confidence interval [CI], 23.3-45.2) vs 33.9 for open (95% CI, 17.8-49.9). The AAS at final follow-up was 26.0 for arthroscopic (95% CI, 21.0-31.0) vs 27.5 for open (95% CI, 19.7-35.2). Both groups had the same tibiotalar angle, lateral talar station, and lateral tibiotalar angle at follow-up. Regression analyses revealed no influence of type of surgery, preoperative deformity, postoperative radiological alignment, age, sex, body mass index, smoking status, etiology of the arthritis, and need for bone grafting on outcome scores (all P > .05). Conclusion: Arthroscopic and open ankle fusion yielded equivalent results for both patient-reported outcome measure and radiographic alignment in patients with coronal and sagittal joint deformity. Patients with higher tibial plafond angles more often underwent open fusion. Level of Evidence: III, comparative series.
Fast event detection method for residential load Demand Side Management

This paper focuses on the application of fast event detection algorithm, to be implemented in a Demand Side Management (DSM) program for Home Energy Management Systems (HEMS). Such HEMS are especially challenging when renewable generation and storage are available, and when electrical demand has to be coordinated with available generation by shifting residential loads which requires load event detection. In this work, we propose a simple and fast load event detection which allows to keep more software and hardware resources for load identification algorithm. Experimental results are performed on some residential loads such as lighting (LED and Compact fluorescent lamp), Kettle and refrigerator to prove the effectiveness of the proposed approach.
Echanges de masse et de chaleur entre deux phases liquides stratifiées dans un écoulement à bulles

Lors d'un hypothetique accident majeur dans un reacteur a eau sous pression, la degradation du coeur peut produire un bain stratifie, traverse par un flux de bulles. Ce dernier influence grandement les transferts thermiques, dont l'intensite est determinante dans le deroulement de l'accident. Dans ce contexte, ce travail porte sur une modelisation de type interface diffuse pour l'etude d'ecoulements incompressibles, anisothermes, composes de trois constituants non miscibles, sans changement de phase. Dans les methodes a interface diffuse, l'evolution du systeme est decrite a travers la minimisation d'une energie libre. L'originalite de notre approche, inspiree du modele de Cahn-Hilliard, reside dans la forme particuliere de l'energie que nous proposons, qui permet d'avoir un modele algebriquement et dynamiquement consistant, au sens suivant : d'une part, l'energie libre triphasique coincide exactement avec celle du modele de Cahn-Hilliard diphasique quand seulement deux des phases sont presentes ; d'autre part, si une phase est initialement absente alors elle n'apparaitra pas au cours du temps, cette derniere propriete etant stable vis a vis des erreurs numeriques. L'existence et l'unicite des solutions faibles et fortes sont demontrees en dimension 2 et 3 ainsi qu'un resultat de stabilite pour les etats metastables. La modelisation d'un systeme ternaire en ecoulement anisotherme est ensuite poursuivie par couplage des equations de Cahn-Hilliard avec celles du bilan d'energie et de Navier-Stokes ou les contraintes surfaciques sont prises en compte a travers des forces volumiques capillaires. L'ensemble est discretise en temps et en espace de facon a preserver les proprietes du probleme continu (conservation du volume, estimation d'energie). Differents resultats numeriques sont presentes, depuis le cas de validation de l'etalement d'une lentille entre deux phases jusqu'a l'etude des transferts de masse et de chaleur a travers une interface liquide/liquide traversee par une bulle ou un train de bulles.
Position Paper : A Roadmap for High Assurance Cryptography

Although an active area of research for years, formal verification has still not yet reached widespread deployment. We outline the steps needed to move from low-assurance cryptography, as given by libraries such as OpenSSL, to high assurance cryptography in deployment. In detail, we outline the need for a suite of high-assurance cryptographic software with per-microarchitecture optimizations that maintain competitive speeds with existing hand-optimized assembly and the bundling of these cryptographic primitives in a new API that prevents common developer mistakes. A new unified API with both formally verified primitives and an easy-to-use interface is needed to replace OpenSSL in future security-critical applications.
THE EFFECTS OF PARENTAL ATTITUDES ABOUT PAIN MANAGEMENT USING ANALGESICS ON THE CHILD ’ S SELF PAIN REPORT

There has been a shift in the management of pediatric pain from the hospital to home setting. Therefore, parents are largely responsible for adequately managing their child’s pain. Unfortunately, parents under treat children’s pain and parental attitudes about using pain medication for children have been highlighted as a barrier. This study examined the impact of parental attitudes on child pain report in pediatric cancer patients, a population vulnerable to the experience of chronic and recurrent pain. Two hundred and eight families of children between the ages of 8-18 who were diagnosed with cancer participated in this study. Parents filled out the Medication Attitudes Questionnaire (MAQ), a survey that assessed three factors of belief about analgesic use for children, including: appropriate use, fear of side effects, and avoidance. The results showed no difference in parental attitudes between children in pain and children without pain. Parental analgesic attitudes were not significantly related with child pain severity except in the case of avoidance or the belief that pain medication would work best only if it is given when the pain is severe. Contrary to what was anticipated, as avoidance increased child pain severity decreased. Further research will inform the complex relationship between parent’s attitudes on pain and children’s reported pain. This will help to improve the child’s quality of life while reducing the physical and psychological aspects on pain.
SELECTIVE SCREENING, ISOLATION AND CHARACTERIZATION OF ANTIMICROBIAL AGENTS FROM MARINE ACTINOMYCETES

Objectives: The present study was concerned with the isolation, screening and characterization of the actinomycetes from the sediments, which are collected from different locations of Bay of Bengal. Materials: Selective enrichment and pretreatment strategies can enhance isolation and screening of novel marine actinomycetes. A total of 15 marine samples were collected from different locations of the Bay of Bengal starting from Visakhapatnam to Singarayakonda. The pre-heat treatment method and a combination of 3 enrichment media were found to be effective in selectively isolating marine actinomycetes. The top five potent isolates were subjected to detailed morphological, cultural, biochemical and physiological characterization. Results: A total of 93 marine actinomycetes were isolated. The antimicrobial activity was studied with all the 93 isolates. The preliminary study of 93 isolates for antimicrobial activity by cross streak method indicated that 36 isolates have antagonistic properties. All these 36 isolates were subjected to submerged fermentation studies. It was observed that 16 isolates (17.2%) exhibited antibacterial activity, 9 isolates (9.6%) showed antifungal activity while 11 isolates (11.8%) showed both antibacterial and antifungal activities. Conclusion: The present study was an attempt to use different methods to screen, select and isolate marine actinomycetes, with intrinsic antimicrobial activity against a variety of microbial pathogens, from the sediments of Bay of Bengal.
YENİLİKÇİ ÖĞRETMEN ÖZELLİKLERİ: BİR ÖLÇEK GELİŞTİRME ÇALIŞMASI

Gunumuzde bilim ve teknolojide meydana gelen degisimler hayatimizin her alanini etkilemektedir. Surekli degisen bir toplum icerisinde egitim sistemi de degismek zorundadir. Hizli degisimlerin ve gelismelerin yasandigi yuzyilimizda, ogretmenlerin de yenilikci ogretmen ozelliklerine sahip olmasi gerekmektedir. Bu calismanin amaci, ogretmenlerin yenilikci ogretmen ozelliklerini belirleyebilmek icin “Yenilikci Ogretmen Ozellikleri Olcegi”ni gelistirmektir. Bu amacla olcegin deneme uygulamasi formu, literatur taranarak, ogretmenlerin ve uzmanlarin gorusleri alinarak olusturulmustur. 105 maddelik madde havuzundan ayni anlama gelen maddeler uzman gorusleri alinarak arastirmacilar tarafindan cikartilmis ve formda 83 madde kalmistir. Olcegin deneme uygulamasi 83 maddeyle yapilmistir. Ankara ilindeki 14 ozel ve kamu fen lisesinde gorev yapmakta olan 200 ogretmene arastirmacilar tarafindan yuz yuze uygulanmistir. Deneme uygulamasi olceginin verileri analiz edildiginde, olcegin genelinden elde edilen Cronbach α guvenirlik katsayisi (.95) guvenirligin yuksek oldugunu gostermektedir. Acimlayici Faktor Analizi (AFA) yapilmis, olcek 53 maddelik, dort faktorlu bir yapida olusmustur. Faktorler “yeniliklere acik ogretmen”, “bilisim teknolojilerine acik ogretmen”, “ogrenmeye acik ogretmen” ve “gelisime ve isbirligine acik ogretmen” olarak nitelendirilmistir. Olcegin tumu icin Cronbach α=0.85 ve her bir alt boyut icin hesaplanan Cronbach α katsayilarinin 0.70’in uzerinde olmasi olcegin butun olarak ve alt boyutlarinin kendi icinde tutarli olduklarina isaret etmektedir. Daha sonra 389 ogretmen uzerinde asil uygulama yapilmistir. Yapilan DFA sonuclarina gore deneme uygulamasinda ortaya konulan yapinin dogrulandigi gorulmustur. Sonuc olarak, yapilan tum gecerlik ve guvenirlik islemleri, olcegin ogretmenlerin yenilikci ogretmen ozelliklerini belirlemede gecerli ve guvenilir bicimde kullanilabilecek bir olcme araci oldugunu ortaya koymaktadir.
Blood-Based Biomarkers Could Help Identify Subclinical Brain Damage Caused by Arterial Hypertension.

ABSTRACT Arterial hypertension is the most prevalent non-communicable disease worldwide, and has long been recognized as a major risk factor for cardiovascular and cerebrovascular diseases. High blood pressure has deleterious consequences on the main target organs (heart, kidney, brain), and several studies have shown that brain damage is more frequent than heart and kidney involvement. Silent lesions can subsequently lead to cognitive decline, dementia or stroke. Nevertheless, screening for subclinical brain deterioration is rarely performed because it requires imaging techniques whose scarcity and high cost rule out routine use by primary care physicians. The challenge is thus early detection of asymptomatic brain lesions with cost-effective techniques to test thousands of patients in the community. In this review we present an update on the status of biomarkers explored as alternatives for early detection of brain damage in arterial hypertension, potentially useful to identify patients needing referrals for brain MRI: ambulatory blood pressure monitoring, quantitative retinal microvascular assessment, quantitative electroencephalography, carotid ultrasonography, neurocognitive studies and blood-based biomarkers. We place special emphasis on blood-based biomarkers, for which our group reported the first preliminary evidence of an association between serum neuron-specific enolase and severity of white matter lesions in patients with essential hypertension. This review consequently explores the potential for blood-based biomarkers to provide a faster, cheaper and more accessible early-detection solution, particularly beneficial in resource-limited settings such as Cuba’s.