Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute myocarditis presenting as acute coronary syndrome: role of early cardiac magnetic resonance in its diagnosis

Background In patients presenting with acute cardiac symptoms, abnormal ECG and raised troponin, myocarditis may be suspected after normal angiography. Aims To analyse cardiac magnetic resonance (CMR) findings in patients with a provisional diagnosis of acute coronary syndrome (ACS) in whom acute myocarditis was subsequently considered more likely. Methods and results 79 patients referred for CMR following an admission with presumed ACS and raised serum troponin in whom no culprit lesion was detected were studied. 13% had unrecognised myocardial infarction and 6% takotsubo cardiomyopathy. The remainder (81%) were diagnosed with myocarditis. Mean age was 45±15 years and 70% were male. Left ventricular ejection fraction (EF) was 58±10%; myocardial oedema was detected in 58%. A myocarditic pattern of late gadolinium enhancement (LGE) was detected in 92%. Abnormalities were detected more frequently in scans performed within 2 weeks of symptom onset: oedema in 81% vs 11% (p<0.0005), and LGE in 100% vs 76% (p<0.005). In 20 patients with both an acute (<2 weeks) and convalescent scan (>3 weeks), oedema decreased from 84% to 39% (p<0.01) and LGE from 5.6 to 3.0 segments (p=0.005). Three patients presented with sustained ventricular tachycardia, another died suddenly 4 days after admission and one resuscitated 7 weeks following presentation. All 5 patients had preserved EF. Conclusions Our study emphasises the importance of access to CMR for heart attack centres. If myocarditis is suspected, CMR scanning should be performed within 14 days. Myocarditis should not be regarded as benign, even when EF is preserved.
NH Approach: Social Responsibility Performance Measurement Case of Mining Industries in Indonesia Stock Exchange

Thisresearch aims to measure the performance of social responsibility of companies in mining industries that are traded in Indonesia Stock Exchange by using NH Approach measurement model. NH Approach is a model of social responsibility performance that is compiled in an integrated manner so that various dimensions of social responsibility take into account such as in terms of environmental dimensions, society, energy, employees, products or consumers, and other forms of social responsibility dimension. The result of the performance measurement of social responsibility shows that in general the grade of social responsibility performance is moderate. That's because of the weak regulation and weak awareness of corporations' understanding about social responsibility. Keywords—Legitimacy, Social Responsibility Performance,
Chronométrage et perception temporelle

Cet article permet de dresser un portrait de certaines avenues contemporaines de recherches dans le domaine de la perception du temps. Après une brève description de différentes catégories d’expériences temporelles, l’article décrit la manière dont la recherche sur le temps psychologique s’inscrit dans une perspective psychophysique. Ensuite, un regard est posé sur ce qui fait varier la sensibilité au temps et la durée perçue. Quatre sources majeures susceptibles de faire varier cette sensibilité sont recensées : la modalité dans laquelle sont délimités les intervalles à estimer, la longueur des délimiteurs, le nombre de présentations des intervalles et le fait de compter explicitement ou non au moment d’estimer le temps. Lorsque l’accent est mis sur la durée perçue des intervalles, trois facteurs d’influence importants sont retenus : l’attention, l’espace entre les délimiteurs ainsi que l’émotion et son expression. L’article enchaîne avec une brève recension des bases biologiques du traitement de l’information temporelle et prend fin sur la description de perturbations du rapport au temps dans quelques pathologies (schizophrénie, maladie de Parkinson et dépression). This article provides an overview of some contemporary research avenues in the field of timing and time perception. After a brief description of different categories of temporal experiences, the article describes how research on psychological time falls within a psychophysical perspective. Next, some factors changing sensitivity to time or perceived duration are reported. Four main sources affecting this sensitivity are identified : the modality in which the intervals to be estimated are marked, the length of the markers, the number of intervals presented, and whether people are counting explicitly or not when estimating time. When emphasis is placed on the perceived duration of intervals, 3 important factors of influence are retained : attention, the space between markers and emotion and its expression. The biological bases required for processing temporal information are then briefly reviewed, and the article ends with the description of perturbations of the relation to time in some pathologies (schizophrenia, Parkinson’s disease and depression).
Reliability and validity test for employee rewards & customer service training and service recovery performance: mediation of organizational commitment in hotel industry

In this study, reliability tests were checked using Cronbach Alpha. Validity tests were checked with all types of validities. Collected data were analysed using SPSS, Excell and AMOS. Results of the reliability revealed that items of rewards, customer service training, organizational commitment and service recovery performance are greater reliability. Convergent validity was measured by unstandardized regression weights (path significance), standardized regression weights (standardized factor loadings), average variance extracted and construct reliability. As per unstandardized regression weights, employee rewards have convergent validity problem. But, customer service training, organizational commitment and service recovery performance have higher convergent validity. In terms of average variance extracted, employee rewards has the problem of convergent validity. Customer service training and organizational commitment have moderate convergent validity. Service recovery performance has higher convergent validity. Results of construct reliability revealed that employee rewards has the problem of construct reliability. Customer service training and organizational commitment have moderate construct reliability. Service recovery performance has higher construct reliability. Results of discriminant validity revealed that values between employee rewards and customer service training; customer service training and organizational commitment; organizational commitment and service recovery performance are somewhat higher. But, all other variables and construct have lower values than others.
Quantitative determinations of neurons and glial cells in the nuclei of the facial and vestibular nerves in man, monkey and dog

The number of Neurons and the Neuronal and glial density per volume of the facial and the vestibural nuclei in two brain stems on each side in man, monkey and dog were counted. The average number of Neurons in the facial nucleus in man (12,500) is greater than in the monkey (4,600), but lower than in the dog (15,800). On the contrary, in the vestibural nuclei the total number of Neurons in man (245,00) is greater than in the monkey (143,000) as in the dog (134,000). The Neuronal density varies considerably in different nucei and different species of animals. At the same time, the glial density is much more even. In all the nuclei the glial density is highest in the dog, lower in the monkey and still lower in man.
Clinical inquiries. Can we prevent splenic rupture for patients with infectious mononucleosis?

■ Evidence summary The annual incidence of infectious mononucleosis is somewhere between 345 and 671 cases per 100,000 in the US; it is highest in the adolescent age group. Splenic rupture is the leading cause of death in infectious mononucleosis, occurring in 0.1% to 0.2% of all cases. Based on this figure, approximately 100 cases of rupture may occur yearly in the US, only a few of which are reported. A retrospective analysis of 8116 patients with infectious mononucleosis at the Mayo Clinic estimated the risk of spontaneous splenic rupture to be 0.1% of cases, correlating with rates found in other studies. The study’s criteria for definite spontaneous rupture are: no recent trauma; recent symptoms; hematologic, serologic, and histologic (splenic) evidence of infectious mononucleosis. Five patients with rupture (average age, 22) were identified; 3 were male. Splenectomy was performed for all patients. Follow-up over 33-years found all patients healthy with minimal subsequent illness. A review of 55 cases found almost all splenic ruptures occurred between the fourth and twenty-first days of illness, and that all affected spleens were enlarged, although only half were palpable on exam. Ninety percent of the ruptures occurred in males, and more than half were nontraumatic. There was no correlation between severity of illness and suscepBrett H. Foreman, MD Carolina Family Practice and Sports Medicine, Cary, NC
Architectural elements in nucleoprotein complexes: interchangeability of specific and non‐specific DNA binding proteins.

Integration host factor (IHF) is required in lambda site‐specific recombination to deform the DNA substrates into conformations active for recombination. HU, a homolog of IHF, can also deform DNA but binds without any apparent sequence specificity. We demonstrate that HU can replace IHF by cooperating with the recombinase protein, integrase, to generate a stable and specific complex with electrophoretic mobility and biochemical activity very close to the complex formed by IHF and integrase. The eukaryotic HMG1 and HMG2 proteins differ entirely in structure from HU but they also bind DNA non‐specifically and induce or stabilize deformed DNA. We show that the eukaryotic HMG1 and HMG2 proteins cooperate with integrase at least as well as does HU to make a defined structure. We also find that the eukaryotic core histone dimer H2A‐H2B can replace IHF, suggesting that the histone dimer is functional outside the context of a nucleosome. HU and the HMG proteins not only contribute to the formation of stable complexes, but they can at least partially replace IHF for the integrative and excisive recombination reactions. These results, together with our analysis of nucleoprotein complexes made with damaged recombination sites, lead us to conclude that the cooperation between HU and integrase does not depend on protein‐protein contacts. Rather, cooperation is manifested through building of higher order structures and depends on the capacity of the non‐specific DNA binding proteins to bend DNA. While all these non‐specific binding proteins appear to fulfil the same bending function, they do so with different efficiencies. This probably reflects subtle structural differences between the assembled complexes.
The Instructional Design for the Web-Based Collaborative Learning System

The benefits of the development of continued social interactions among individuals in an educational environment have been well documented in the literature. Nonetheless, few instructional design strategies are available to instructors for the development of Web-base learning environment. The instructional design strategies basing on the social interaction theory and corresponding instructional activities that have been imported into our previous system have been introduced and the Theoretical foundation of these strategies has been discussed in this paper.
[Atherosclerosis and cerebral infarction].

BACKGROUND Approximately half of all cerebral infarctions are caused by artery-to-artery emboli from atherosclerotic plaques in the aorta and pre- or intracranial arteries. This review article presents an update on the development of atherosclerotic plaques, and discusses the diagnostic and therapeutic implications of new pathophysiological knowledge of atherosclerosis in relation to cerebral infarction. MATERIAL AND METHODS The article is based on our own clinical-neurological experience and publications mainly on intima-media thickness (IMT) and ultrasound in the diagnosis of cerebrovascular disease, identified through a Medline search. RESULTS Unstable plaques have a thin and vulnerable capsule, inflammatory cells, high fat content and often intra-plaque bleeding. Calcium deposition and organized fibrous tissue have a stabilizing effect. The development of atherosclerosis and biological characteristics of plaques can be explained by known vascular risk factors and genetic disposition. Ultrasound examination of the aorta and pre-cerebral arteries can be used to assess the degree of atherosclerosis and to provide important information regarding patients' risk of cerebrovascular disease. INTERPRETATION New knowledge regarding the pathophysiology of atherosclerosis can improve prediction of a patient's risk for ischemic stroke. This forms the basis for a better and more individualized prophylactic treatment of cerebrovascular disease.
On-line interrogation of pebble bed reactor fuel

Pebble bed reactors are characterized by multipass fuel systems in which spherical fuel pebbles are circulated through the core until they reach a proposed burnup limit (80,000 - 100,000 MWD/MTU). For such reactors, the fuel is assayed on-line to ensure that the burnup limit is not breached. We considered assaying the fuel using an HPGe detector to perform passive gamma-ray spectrometry of fission products. Since neither fresh nor irradiated fuel is readily available, computer simulations were utilized to identify the radionuclides that can be used as burnup indicators, and to visualize the gamma ray spectra at various levels of burnup. Specifically, we used the ORIGEN-MONTEBURNS-MCNP code system. This allowed the establishment of the burnup dependent one-group gas reactor cross sections for the radionuclides of interest. Subsequently, ORIGEN was used to simulate in-core pebble depletion to establish the irradiated pebble isotopics. Finally, the codes MCNP and SYNTH were used to simulate the response of the HPGe gamma-ray spectrometer. The results show that absolute and relative indicators can be used on-line to determine unambiguously the enrichment and burnup on a pebble-by-pebble basis. The activity of Cs-137 or the activity ratio of Co-60/Cs-134 can be combined with the activity ratio of Np-239/I-132 to yield the enrichment and burnup information. To use the relative indicators, a relative efficiency calibration of the gamma-ray spectrometer can be performed using the La-140 gamma lines that are emitted by the irradiated pebble. I-132, Cs-134, Cs-137, La-140 and Np-239 are produced upon the irradiation of the fuel. Co-60 is produced by doping the fuel with a small amount (/spl sim/100 ppm) of Co-59. Using this approach, the uncertainty in burnup determination due to factors such as power history variation, efficiency calibration, and counting statistics is expected to remain within /spl plusmn/5%.
Characteristics of Exposure to Particles due to Incense Burning inside Temples in Kanpur, India

ABSTRACTIncense burning in temples is a common and popular ritual in India and other Asian countries. This study aims at assessing the quantity and size segregated distribution of particulate matter in temples of Kanpur city, India. Active air sampling was performed in three temples using the Micro Orifice Uniform Deposit Impactor (MOUDI). PM10 mass concentrations as high as 2184 µg m–3 were recorded inside the temples. Mass concentration values for all samples exceeded the Central Pollution Control Board (CPCB) National Ambient Air Quality Standard (NAAQS) of 100 µg m–3. Particle counts were high, and more than 99% of the numbers of particles generated were PM2.5. Particle coagulation is an active mechanism leading to formation of polydispersed particles. Most abundant particles occur in the accumulation mode (dp < 1 µm). Ventilation conditions and amount of incense burned are major factors affecting particle size distribution. Exposure through inhalation, to critically high concentrations of fine particulate matter generated via incense smoke especially for worshippers who frequent the temple and temple workers, raises health concerns. The results clearly indicate that incense smoke is a major source of particulate matter in the temple microenvironment and their chemical characteristics need further examination.
Distribution of Cortical Interneurons in Grey Matter Heterotopia in Patients with Epilepsy

Summary: Purpose: Grey matter heterotopia are well‐defined malformations of the cortex often associated with severe epilepsy. Defects have been identified in genes, including DCX and FLN1, that influence radial migration of postmitotic cells from the ventricular zone to the cortical plate. A proportion of cortical γ‐aminobutyric acid (GABA)‐containing interneurons may arise from the ganglionic eminence of the ventral telencephalon. We aimed to identify the subtypes and localisation of interneurons within grey matter heterotopia relative to cortex.
Dual-Source Energy Storage – Control and Performance Advantages in Advanced Vehicles

This paper introduces a methodology for evaluating and segregating load requirements and characteristics to size hybrid energy source/storage elements for handling the types of loads for which they are best suited. This work focuses on investigating the use of a dual-source battery and ultracapacitor pack in place of the seemingly unattainable (in satisfying cost, power, energy, and reliability requirements) single-battery solution that is being sought for hybrid electric applications. However, this methodology is general enough to be applied (with adequate knowledge of load profiles) to any application with two or more source/storage elements. A prerequisite for segregating loads is to use “expert” knowledge to characterize the various sources’ strengths and weaknesses. Component role segregation should facilitate (1) various control method evaluation for real-time implementation of the multi-source solution (without prior profile knowledge), and (2) optimization routines to further adjust component sizing and control variables to maximize fuel economy objectives and minimize mass, volume, and (possibly) cost objectives. This paper provides the general methodology and an example battery and ultracapacitor combination for a midsize hybrid electric vehicle.
Impaired growth hormone secretion in the adult population: relation to age and adiposity.

Growth hormone (GH) release was studied in adults of normal stature, ages 21-86 yr. The subjects were 85-115% of ideal body weight, between the 5th and 95th percentiles in height, and free of active or progressive disease. 9 to 12 individuals in each decade from thirds to ninth were evaluated. The following criteria of GH status were measured: serum GH concentration, analyzed by radioimmunoassay at half-hour intervals for 4 h after onset of sleep, and at 1-h intervals from 8 a.m. to 4 p.m. in 52 subjects; daily retention of N, P, and K in response to 0.168 U human (h)GH/kg body wt3/4/day in 18 subjects; and plasma somatomedin C (SmC) level before and during exogenous hGH treatment in 18 subjects. All 10 individuals, 20-29 yr old, released substantial amounts of endogenous GH during both day and night (average peak serum GH obtained during day and night was 7.3 and 20.3 ng/ml, respectively); average plasma SmC was 1.43 U/ml (95% tolerance limits, 0.64-2.22 U/ml). There was no significant effect of exogenous hGH on elemental balances or on plasma SmC. In contrast, 6 of 12 individuals 60-79 yr old showed the following evidences of impaired GH release; peak waking and sleeping serum GH less than 4 ng/ml; plasma SmC less than 0.38 U/ml; a significant retention in N, P, and K; and a significant rise in plasma SmC, in response to exogenous hGH. Plasma SmC, serum GH during sleep, serum GH during the day, retentions of N, P, and K in response to exogenous hGH, and rise in plasma SmC in response to hGH were all intercorrelated (P less than 0.05). Plasma SmC less than 0.38 U/ml corresponded to peak nocturnal serum GH less than 4 ng/ml. The prevalence of plasma SmC less than 0.38 U/ml increased progressively from age 20 to 90: third decade, 0%; fourth, 11%; fifth, 20%; sixth, 22%; seventh, 42%; eight, 55%; and ninth, 55%. Within each decade, plasma SmC was inversely related to adiposity.
Surface chemical properties of purified root cell walls from two tobacco genotypes exhibiting different tolerance to manganese toxicity.

Surface chemical characteristics of root cell walls extracted from two tobacco genotypes exhibiting differential tolerance to Mn toxicity were studied using potentiometric pH titration and Fourier transform infrared spectroscopy. The Mn-sensitive genotype KY 14 showed a stronger interaction of its cell wall surface with metal ions than did the Mn-tolerant genotype Tobacco Introduction (T.I.) 1112. This observation may be attributed to the relatively higher ratio of COO(-) to COOH in KY 14 cell walls than that found in the cell walls of T.I. 1112 in the pH range of 4 to 10. For both genotypes, the strength of binding between metal ions and cell wall surface was in the order of Cu > Ca > Mn > Mg > Na. However, a slightly higher preference of Ca over Mn was observed with the T.I. 1112 cell wall. This may explain the high accumulation of Mn in the leaves of Mn-tolerant genotype T.I. 1112 rather than the high accumulation of Mn in roots, as occurred in Mn-sensitive KY 14. It is concluded that surface chemical characteristics of cell walls may play an important role in plant metal ion uptake and tolerance.
Cutting Edge: Oral Type I IFN-τ Promotes a Th2 Bias and Enhances Suppression of Autoimmune Encephalomyelitis by Oral Glatiramer Acetate1

IFN-τ, a novel type I IFN that possesses immunomodulatory properties, lacks toxicity normally associated with other type I IFNs. We examined the effects of oral IFN-τ alone and in combination with oral glatiramer acetate in experimental allergic encephalomyelitis (EAE). By comparison of oral administration of IFN-α, -β, and -τ to myelin basic protein-specific TCR-transgenic mice, we demonstrate these type I IFNs promote secretion of the Th2 cytokine IL-10 with similar efficiency. Whereas IFN-α and -β induced IFN-γ secretion, a Th1 cytokine, IFN-τ did not. Oral IFN-τ alone suppressed EAE. When suboptimal doses were administered orally in combination to wild-type mice, IFN-τ and glatiramer acetate had a synergistic beneficial effect in suppression of EAE. This combination was associated with TGF-β secretion and enhanced IL-10 production. Thus, IFN-τ is a potential candidate for use as a single agent or in combination therapy for multiple sclerosis.