Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiac baroreflex control in humans during and immediately after brief exposure to simulated high altitude

To examine the baroreflex response in humans during and immediately after acute hypoxia exposure, the cardiac baroreflex sensitivity (BRS) was studied using adaptation of RR intervals in response to spontaneous systolic blood pressure fluctuations (sequences methodology) in 11 unacclimatized subjects. All measurements were made under fixed breathing rate, and realized consecutively at baseline level (20 min), at an inspired oxygen concentration of 11% (15 min) and again under normoxic conditions (20 min; recovery period). The spontaneous baroreflex response decreases progressively during hypoxic exposure, causing a tachycardic response at this FiO2 without any significant alteration of the systolic or diastolic blood pressure. The magnitude of decrease for this variable at the end of exposure averaged 42·9 ± 15·6%. The simultaneous spectral analysis of heart rate (HR) variability in hypoxic condition confirmed an alteration in the parasympathetic activity (HFnu: −17·8 ± 30·9% versus basal conditions, P<0·01) counterbalanced by an exaggerated sympathetic activity (LFnu: +33 ± 42·4%, P<0·05) at the sinus node. Interestingly, we could observe an enhanced cardiac baroreflex response during the period following the inhalation of the hypoxic mixture (+130·6 ± 15·6% of basal conditions, P<0·001). There is a relationship with a significant and abrupt increase in the parasympathetic control of HR (mean HR reached 111 ± 8·1% of the mean basal HR, P<0·01). These results suggest that brief exposure to hypoxia under rate‐controlled ventilation is associated with a significant alteration in the spontaneous cardiac baroreflex. This important cardiac autonomic imbalance is followed by a significant increase in the cardiac parasympathetic drive even after the disappearance of the hypoxic stimulus.
Analysis and Design of a Thermoelectric Energy Harvesting System With Reconfigurable Array of Thermoelectric Generators for IoT Applications

In this paper, a novel thermoelectric energy harvesting system with a reconfigurable array of thermoelectric generators (TEGs), which requires neither an inductor nor a flying capacitor, is proposed. The proposed architecture can accomplish maximum power point tracking (MPPT) and voltage conversion simultaneously via the reconfiguration of the TEG array, and demonstrate significantly improved power conversion efficiency over the conventional switching converter and switched-capacitor architectures. Two systematical scaling approaches—powers-of-two scaling and maximum-factor scaling—are presented and analyzed to serve as the design guideline, catering for reconfigurable TEG arrays of different sizes. In order to optimize the chip area required, a custom-designed, multi-level hierarchy and systematically scalable switch array that requires a reasonable number of switches is also developed to enable the reconfiguration of the TEG array. The 16-node and 12-node versions of the proposed system have been implemented in a standard 0.35- $\mu \text{m}$ CMOS process. Measurement results verify the analysis, and confirm that the proposed system can maintain a higher than 88.8% efficiency over a wide range of temperature gradients.
Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors

Germline mutations and deletions of SMARCB1/INI1 in chromosome band 22q11.2 predispose patients to rhabdoid tumor and schwannomatosis. Previous estimates suggested that 15–20% of rhabdoid tumors were caused by an underlying germline abnormality of SMARCB1. However, these studies were limited by case selection and an inability to detect intragenic deletions and duplications.
Bioremediation of petroleum-contaminated soil by a combined system of biostimulation–bioaugmentation with yeast

This paper presents a study of the effect of a combined biostimulation–bioaugmentation treatment applied to a clay-loam soil contaminated with 16,300 mg/kg of total petroleum hydrocarbons (TPH), which comprised 51% saturated hydrocarbons and 31% aromatic hydrocarbons. The bioaugmentation was performed with yeast Candida tropicalis SK21 isolated from petroleum-contaminated soil. The strain was able to grow in a pH range of 3–9 in liquid culture, and the optimum pH was found to be 6 for both growth and biosurfactant production. At pH 6, 96% and 42% of TPH were degraded by the strain at the initial diesel oil concentrations of 0.5% and 5% (v/v), respectively. The remediation via inoculating the yeast removed 83% of TPH in 180 days while the experiment with the indigenous microorganisms alone removed 61%. Microbial enumeration showed that the yeast SK21 could grow good in the soil. It was also found that dehydrogenase and polyphenoloxidase activities in soil were remarkably enhanced by the inoculation of the yeast.
Equalizer Sharing in Wireless Communications: Simulation Study

This paper presents a simulation study for code-division multiplex system, over time varying channels. The scheme investigated here uses a sharing technique for the signal processing unit between the transmitter and the receiver to improve the performance of the system. This technique minimizes the effect of inter-symbol interference (ISI). The data itself is transmitted in the form of blocks of data symbols separated by blocks of no signal. The appropriate length of each data block depends on the channel parameters expected and the allowed complexity. The impulse response is required to be known at the transmitter which is the requirement for all systems that employ coding at the transmitter.
Hepatitis C therapy in non‐genotype 1 patients: the near future

Summary. Worldwide, 50–70 million subjects are infected with an hepatitis C virus (HCV) genotype 2, 3, 4, 5 or 6. In these patients, the combination of PEG‐INF‐α and ribavirin remains the currently approved standard‐of‐care treatment. The identification of different potential therapeutic targets in the HCV life cycle has led to the development of both direct antiviral agents (DAAs) and reagents targeting host functions essential for viral replication. DAAs comprise so far first‐generation, second‐wave and second‐generation NS3/4A protease inhibitors (PIs), nucleos(t)ide (NIs) and non‐nucleoside inhibitors of the NS5B RNA polymerase and NS5A complex inhibitors. The main host‐protein‐directed antiviral agents are cyclophilin inhibitors and silibinin. Whereas the launch of first‐generation PIs was a major landmark in the management of genotype 1 (GT‐1)‐infected patients, these drugs are inactive in most non‐GT‐1‐infected patients. Several of these and other drugs have now reached phase II and even phase III clinical stage development. The purpose of this article is to provide an overview of the clinical results recently reported for the treatment for non‐GT‐1 HCV infection with a focus on the most promising new compounds and combinations.
Spermaturia in two normal boys without other signs of puberty

Nysom K, Pedersen JL, Jørgensen M, Nielsen CT, Müller J, Keiding N, Skakkebæk NE. Spermaturia in two normal boys without other signs of puberty. Acta Paediatr 1994:83:520–1. Stockholm. TSSN 0803–5253
Uptake of dextran‐coated monocrystalline iron oxides in tumor cells and macrophages

Although several dextran‐coated iron oxide preparations are in preclinical and clinical use, little is known about the mechanism of uptake into cells. As these particles have been shown to accumulate in macrophages and tumor cells, we performed cellular uptake and inhibition studies with a prototypical monocrystalline iron oxide nanoparticle (MION). MION particles were labeled with fluorescein isothiocyanate or radioiodinated and purified by gel permeation chromatography. Two preparations of MION particles were used in cell experiments: nontreated MION and plasma‐opsonized MION purified by gradient density purification. As determined by immunoblotting, opsonization resulted in C3, vitro‐nectin, and fibronectin association with MION. Incubation of cells with fluorescent MION showed active uptake of particles in macrophages both before and after opsonization. In C6 tumor cells, however, intracellular MION was only detectable in dividing cells. Quantitatively, 125I‐labeled MION was internalized into cells with uptake values ranging from 17 ng (in 9L gliosarcoma) to 970 ng iron per million cells for peritoneal macrophages. Opsonization increased MION uptake into macrophages sixfold, whereas it increased the uptake in C6 tumor cells only twofold. Results from uptake inhibition assay suggest that cellular uptake of nonopsonized (dextran‐coated) MION particles is mediated by fluid‐phase endocytosis, whereas receptor‐mediated endocytosis is presumably responsible for the uptake of opsonized (protein‐coated) particles.
From Social Play to Social Games and Back

The social dimensions can take many forms in games and play cultures. The phenomenon of social network games, especially the historical evolution of Facebook games, provides an interesting opportunity to explore of the social aspects of game creation and play cultures. The social and cultural frames of social play and networks have become increasingly central areas to explore in game research. Around years 2006-2007, games distributed through social network services became known as ‘social games’, even though their actual characteristics do not necessarily rely primarily on social interaction, or real-time social play, for example. Nevertheless, social play and social network services have had a central role for the design and use of these games, and it is important to understand how they have operated – as games, and as playful elements in particular kind of social media environment. This chapter draws upon a decade of research in the field of casual and social games, and highlights the interrelations between player experiences, game and service design features, as well as industry business models in this area. Finally, the chapter also reflects on the future directions of social game play, and its research.
Cardiac MRI of the normal and hypertrophied mouse heart

With the development of recent transgenic techniques, studies involving mice offer opportunities to increase understanding of cardiac disease. This provides motivation for the current study to perform noninvasive evaluation of the normal and hypertrophied mouse heart with MRI. By acquiring EGG and respiratory signals, the MR image acquisition was gated to both the cardiac and respiratory cycles. Combining a spin‐warp imaging sequence with an RF surface coil resulted in short‐axis images that allowed quantification of in vivo cardiac mass. Excellent agreement between MRI‐determined (y) and postmortem heart weight (x) was obtained: y = 0.991x + 1.43 (r = 0.996). Isoproterenol, at 282 μMmol/kg body weight (BW) and 573 μMmol/kg BW, induced a dose‐dependent increase in the ratio of heart weight to BW of 16.8 ± 1.09% and 24.1 ± 1.71 %, respectively, which was accurately measured by MRI. These results demonstrate the ability of MRI to non‐invasively monitor cardiac anatomy in the mouse.
PAF-degrading acetylhydrolase is preferentially associated with dense LDL and VHDL-1 in human plasma. Catalytic characteristics and relation to the monocyte-derived enzyme.

In human plasma, platelet activating factor (PAF)-degrading acetylhydrolase (acetylhydrolase) is principally transported in association with LDLs and HDLs; this enzyme hydrolyzes PAF and short-chain forms of oxidized phosphatidylcholine, transforming them into lyso-PAF and lysophosphatidylcholine, respectively. We have examined the distribution, catalytic characteristics, and transfer of acetylhydrolase activity among plasma lipoprotein subspecies separated by isopycnic density gradient ultracentrifugation; the possibility that the plasma enzyme may be partially derived from adherent monocytes has also been evaluated. In normolipidemic subjects with Lp(a) levels < 0.1 mg/mL, acetylhydrolase was associated preferentially with small, dense LDL particles (LDL-5; d = 1.050 to 1.063 g/mL) and with the very-high-density lipoprotein-1 subfraction (VHDL-1; d = 1.156 to 1.179 g/mL), representing 23.9 +/- 1.7% and 20.6 +/- 3.2%, respectively, of total plasma activity. The apparent Km values for PAF of the enzyme associated with such lipoproteins were 89.7 +/- 23.4 and 34.8 +/- 4.5 mumol/L for LDL-5 and VHDL-1, respectively: indeed, the Km value for LDL-5 was some 10-fold higher than that of the light LDL-1, LDL-2, and LDL-3 subspecies, whereas the Km of VHDL-1 was some twofold greater than those of the HDL-2 and HDL-3 subspecies. Furthermore, when expressed on the basis of unit plasma volume, the Vmax of the acetylhydrolase associated with LDL-5 was some 150-fold greater than that in LDL-1 (d = 1.019 to 1.023 g/mL). No significant differences in the pH dependence of enzyme activity or in sensitivity to protease inactivation, sulfydryl reagents, the serine protease inhibitor Pefabloc, or the PAF antagonist CV 3988 could be detected between apo B-containing and apo A-I-containing lipoprotein particle subspecies. Incubation of LDL-1 (Km = 8.4 +/- 2.6 mumol/L) and LDL-2 (d = 1.023 to 1.029 g/mL; Km = 8.4 +/- 3.3 mumol/L) subspecies with LDL-5, in which acetylhydrolase had been inactivated by pretreatment with Pefabloc, demonstrated preferential transfer of acetylhydrolase to LDL-5. Acetylhydrolase transferred to LDL-5 from the light LDL subspecies exhibited a Km of 9.4 +/- 2.2 mumol/L, a value characteristic of the particle donors. Finally, acetylhydrolase (Km = 23.4 +/- 7.6 mumol/L) released by adherent human monocytes in culture was found to bind preferentially to small, dense LDL subspecies upon incubation of Pefabloc-inactivated plasma with monocyte supernatant. (ABSTRACT TRUNCATED AT 400 WORDS)
Evolution of Government Policies on Guiding Corporate Social Responsibility in China

This paper aims to unearth the ways in which the Chinese government uses policies to guide corporate social responsibility (CSR) development in China. Co-word analysis, cluster analysis, and network analysis were conducted on the relevant policy documents from 2005 to 2013 from the Chinese government. This paper illustrates the evolution of industry involvement in metagovernance of CSR, the evolution of intergovernmental relations in CSR policy formulation, and the evolution of policy relations on guiding CSR. The quantitative text analysis on policy documents reveals policy intentions and maps policy process, advancing understanding of policy orientation and evolution. The CSR reports of the same period of the State Grid in China are used as empirical evidence to validate the policy evolution. This work presents the overall evolution of the ways in which the Chinese government deployed its guiding strategy on CSR, and empirically demonstrates the organization of metagovernance maneuvered by China’s government to promote CSR development in China. It provides perspective and methods to analyze China’s networked government policies, and empirically answers the central question of metagovernance about the ways in which the organization of metagovernance is carried out.
Reliability of the International Knee Documentation Committee Radiographic Grading System

Background The International Knee Documentation Committee (IKDC) forms are commonly used to measure outcomes after anterior cruciate ligament (ACL) reconstruction. The knee examination portion of the IKDC forms includes a radiographic grading system to grade degenerative changes. The interrater and intrarater reliability of this radiographic grading system remain unknown. Hypothesis We hypothesize that the IKDC radiographic grading system will have acceptable interrater and intrarater reliability. Study Design Case series (diagnosis); Level of evidence, 4. Methods Radiographs of 205 ACL-reconstructed knees were obtained at 5-year follow-up. Specifically, weightbearing posteroanterior radiographs of the operative knee in 35° to 45° of flexion and a lateral radiograph in 30° of flexion were used. The radiographs were independently graded by 2 sports medicine fellowship—trained orthopaedic surgeons using the IKDC 2000 standard instructions. One surgeon graded the same radiographs 6 months apart, blinded to patient and prior IKDC grades. The percentage agreement was calculated for each of the 5 knee compartments as defined by the IKDC. Interrater reliability was evaluated using the intraclass correlation coefficient (ICC) 2-way mixed effect model with absolute agreement. The Spearman rank-order correlation coefficient (rs) was applied to evaluate intrarater reliability. Results The interrater agreement between the 2 surgeons was 59% for the medial joint space (ICC = 0.46; 95% confidence interval [CI] = 0.35-0.56), 54% for the lateral joint space (ICC = 0.45; 95% CI = 0.27-0.58), 49% for the patellofemoral joint (ICC = 0.40; 95% CI = 0.26-0.52), 63% for the anterior joint space (ICC = 0.20; 95% CI = 0.05-0.34), and 44% for the posterior joint space (ICC = 0.28; 95% CI = 0.15-0.40). The intrarater agreement was 83% for the medial joint space (rs = .77, P < .001), 86% for the lateral joint space (rs = .76, P < .001), 81% for the patellofemoral joint (rs = .79, P < .001), 91% for the anterior joint space (rs = .48, P < .001), and 69% for the posterior joint space (rs = .64, P < .001). Conclusions While intrarater reliability was acceptable, interrater reliability was poor. These findings suggest that multiple raters may score the same radiographs differently using the IKDC radiographic grading system. The use of a single rater to grade all radiographs when using the IKDC radiographic grading system maximizes reliability.
Potential role of tRNAs in wheat and Lolium mitochondrial rps7 transcript processing.

The wheat mitochondrial gene for ribosomal protein S7 exhibits multiple transcripts that share the same 3' terminus but range in overall length from 3.4 to 0.7 kb because of 5'end-maturation events. The longest detectable precursor RNA maps precisely to the 3' end of a chloroplast-origin tRNA-Phe gene, consistent with it providing signals for endonucleolytic cleavage. Steady-state levels of precursor RNAs were seen to be lower in seedlings than in germinating embryos, although the degree of editing within untranslated regions (UTRs) was higher in seedlings. In another grass, Lolium multiflorum Lam. , rps7 displays transcripts of 1.3 and 0.7 kb, and although the distal 5' UTRs are unrelated in sequence to those of wheat, the 5' terminus of the longer transcript also maps to a tRNA gene, in this case the native mitochondrial-type tRNA-Ser. Our findings illustrate the plasticity of plant mitochondrial transcriptional units and the recruitment of chloroplast-origin sequences for the expression of mitochondrial genes.
Fetal umbilical artery velocity waveforms and subsequent neonatal outcome

Summary. Flow velocity waveforms (FVWs) from the fetal umbilical artery were recorded from 2178 pregnant women over a 6‐year period. All of them had an obstetric factor indicating increased risk of fetal compromise. A total of 6749 studies was recorded. The systolic diastolic (AB) ratio was measured and classified as normal (<95th centile), elevated (95–99th centile), high (>99th centile) or extreme (absent diastolic flow). The results of these studies have been related to subsequent fetal and neonatal outcome. An abnormal umbilical artery FVW was associated with shorter gestation and infants with lower birthweight, shorter length and lower ponderal index. There was a highly significant association between an abnormal FVW and the birth of an infant small for gestational age. The significance of the association increased with the increased abnormality of the umbilical artery FVW and this was independent of gestational age. Preterm infants associated with high or extreme AB ratios spent twice as long in the neonatal nursery than those with normal AB ratios. Analysis of 794 pregnancies studies serially indicated that an abnormal FVW in which the AB ratio was increasing, in contrast to a decreasing AB ratio, predicted a poor outcome for both size at birth and duration of neonatal intensive care. We conclude that in high risk pregnancy Doppler umbilical artery FVW studies predict the most compromised fetuses in terms of growth retardation and requirements for neonatal intensive care.
Triphasic decline of hepatitis C virus RNA during antiviral therapy

When patients chronically infected with hepatitis C virus (HCV) are placed on antiviral therapy with pegylated interferon (IFN)‐α or IFN‐α plus ribavirin (RBV), HCV RNA generally declines in a biphasic manner. However, a triphasic decline has been reported in a subset of patients. A triphasic decline consists of a first phase (1‐2 days) with rapid virus load decline, followed by a “shoulder phase” (4‐28 days) in which virus load decays slowly or remains constant, and a third phase of renewed viral decay. We show that by including the proliferation of both uninfected and infected cells, a viral kinetic model can account for a triphasic HCV RNA decay. The model predicts that a triphasic decline occurs only in patients in which a majority of hepatocytes are infected before therapy. The shoulder phase does not represent the intrinsic death rate of infected cells, but rather the third phase slope is close to the intrinsic death rate of infected cells when overall drug efficacy is close to 1. Conclusion: Triphasic responses can be predicted from a generalization of existent viral kinetic models through the inclusion of homeostatic proliferation of hepatocytes. This generalized model can also explain the viral kinetics seen in flat partial responders. Finally, the enhanced third phase in patients treated with IFN‐α in combination with RBV versus patients treated with IFN‐α alone can be explained by a mutagenic effect of RBV against HCV. (HEPATOLOGY 2007;46:16–21.)
Effective event description using trend template language and efficient intrusion detection

Trend template language, TTL, is considerably a new approach for describing computer intrusion events. Its inherent strength of linguistic constructs could help describe events more effectively which can help detection process overcome limitations of current intrusion detection techniques to detect attack trends. Some researches have been already conducted establishing the strength and possibilities of TTL as an event description language over some traditional approaches. This article goes further with TTL and dissects the possibilities and limitations of TTL and trend detection with practical view point.