Miracle-dz/UniFAR-FTUs huggingface dataset:
High levels of genetic structure in the Australian freshwater fish, Ambassis macleayi

Abstract The genetic structure of the freshwater fish Ambassis macleayi Castelnau 1878 was explored across the tropical catchments of the Gulf of Carpentaria Basin, northern Australia. The Gulf of Carpentaria provides a unique opportunity to explore simultaneously contemporary and historical gene flow resulting from unique climatic patterns and historical connectivity among catchments via a freshwater lake that existed during lower sea levels. The control region of the mtDNA genome and 4 microsatellite loci were used to detect significant genetic structure among and within catchments. Within catchments, genetic structure suggested that dispersal of A. macleayi is restricted, despite high levels of connectivity during summer monsoonal events. Among catchments, divergence appeared to be deeper than what would be predicted based on the last opportunity for connectivity via the lake of Carpentaria (∼10,000 years before present [ybp]). Overall, these results have important implications for A. macleayi and other members of this genus. If individuals are not proficient dispersers, recolonization after disturbance will be limited. Because of historical isolation among catchments, each catchment harbors unique genetic diversity that should be conserved independently.
2 Detecting Deterministic Functions in Functional-Logic Programs

This paper presents the integration of the optimization known as dynamic cut within the functional-logic system T OY . The implementation automatically detects deterministic functions at compile time, and includes in the generated code the test for detecting at run-time the computations that can actually be pruned. The outcome is a much better performance when executing deterministic functions including either or-branches in their definitional trees or extra variables in their conditions, with no serious overhead in the rest of the computations. The paper also proves the correctness of the criterion used for detecting deterministic functions w.r. t. the semantic calculus CRWL.
and YK Gupta lymphocytes of rats Evaluation of genotoxic potential of commonly used organophosphate pesticides in peripheral blood

Chlorpyrifos (CPF), methyl parathion (MPT), and malathion (MLT) are among the most extensively used organophosphate (OP) pesticides in India. DNA protein cross-links (DPC) and DNA strand breaks are toxic lesions associated with the mechanism(s) of toxicity of carcinogenic compounds. In the present study, we examined the hypothesis that individual and interactive genotoxic effects of CPF, MPT, and MLT are involved in the formation of DPC and DNA strand break. The DNA strand break was measured by comet assay and expressed as DNA damage index, while DPC estimation was carried out by fluorescence emission assay. The results showed that exposure of rat lymphocytes with CPF, MPT, and MLT caused significantly marked increase in DNA damage and DPC formation in time-dependent manner. MPT caused the highest damage, and these pesticides do not potentiate the toxicity of each other.
Nikolopoulos, L and Boulougouris, E and Khorasanchi, M (2016) Applications of holistic ship theory for the simulation driven optimization of the design and operation of large bulk carriers. In: Energy Efficient Ships

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GFAP and UCH-L 1 as outcome predictors in traumatic brain injury

Object: Biomarkers ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) may help detect brain injury, assess its severity and improve outcome prediction. This study aimed to evaluate their prognostic value during the first post-injury days. Methods: Serum UCH-L1 and GFAP were measured from 324 patients with traumatic brain injury (TBI) enrolled in a prospective study. The outcome was assessed using Glasgow Outcome Scale (GOS) or its extended version (GOSe). Results: Patients with full recovery had lower UCH-L1 concentrations on second day and patients with favourable outcome during the first two days than patients with incomplete recovery and unfavourable outcome. Patients with full recovery and favourable outcome had significantly lower GFAP concentrations on the first two days than patients with incomplete recovery or unfavourable outcome. There was a strong negative correlation with the outcome and UCH-L1 on the first three days and GFAP levels on the first two days. Both UCH-L1 and GFAP upon arrival distinguished patients with GOS 1-3 from GOS 4-5 patients but not patients with GOSe8 from GOSe 1-7. For UCH-L1 and GFAP to predict unfavourable outcome (GOS ≤ 3), the AUC was 0.727, and 0.723, respectively. Neither UCHL-1 nor GFAP was independently able to predict the outcome, when age, worst GCS, pupil reactivity, Injury Severity Score, and Marshall score were added into multivariate logistic regression model. Conclusion: GFAP and UCH-L1 are significantly associated with outcome but they do not add predictive power to commonly used prognostic variables in a TBI population of varying severities. M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Riikka Takala 8
An exploration of B2B social media practices in an era of digital transformation: the case of the pharmaceutical industry in Thailand

Research suggests that humans’ experiences have been significantly impacted by the digitisation of communication technologies (Castell, 2001). In this digital context, marketing practices in the B2B sector have shifted towards leveraging new technologies (Goggin, 2012) and new platforms such as social media. While some studies support the view that digitalisation processes have largely produced positive impacts, in turn creating marketing opportunities especially in emerging growing markets such as Thailand (Ansari and Phillips, 2011; Gross, 2014); others point to the associated tensions that arise from that particular digital environment where technology demands challenge firms’ traditional frames of reference, stability and resources, thus threatening current strategies (Andriessen et al, 2011; Santos and Eisenhardt, 2009). Tension is defined as “clash of ideas or principles or actions and… the discomfort that may arise as a result” (Stohl et al.; 2001 pp.353, 354). As such, leveraging the power of social media in B2B (Pharmaceutical sector) is somehow under investigated especially in the context where strong legal constraints are present (Ventrataram and Nagatode, 2014; Whalen, 2012; Liu, 2011). The aim of this study is to explore how and to what extent pharmaceutical stakeholders (firm, physician and pharmacist) are starting to leverage the power of social media communication. Sale force management and social media literature is utilized together with literature on communication and innovation management in B2B. Findings from 23 in depth interviews (6 physicians, 7 pharmacists and 10 managers from a leading global pharmaceutical firm) are analysed. Themes such as content acceptance, self-efficacy, control, managerial tensions, technical issue (security and privacy) and legislation impact are found to be relevant. In addition, cultural factors appear to also mediate engagement by stakeholders. Theoretical implication of social media communication in B2B sector under strong and evolving legislative conditions are discussed together with the emerging managerial implications for the pharmaceutical industry of digital transformation in an era of accelerated culture.
Bank Savings and Bank Credits in Nigeria: Determinants and Impact on Economic Growth

This study investigated the determinants of bank savings in Nigeria as well as examined the impact of bank savings and bank credits on Nigeria’s economic growth from 1970- 2006. We adopted two impact models; Distributed Lag-Error Correction Model (DL-ECM) and Distributed Model. The empirical results showed a positive influence of values of GDP per capita (PCY), Financial Deepening (FSD), Interest Rate Spread (IRS) and negative influence of Real Interest Rate (RIR) and Inflation Rate (INFR) on the size of private domestic savings. Also a positive relationship exists between the lagged values of total private savings, private sector credit, public sector credit, interest rate spread, exchange rates and economic growth. We therefore recommend, among others, that government’s effort should be geared towards improving per capita income by reducing the unemployment rate in the country in a bid to accelerate growth through enhanced savings.
2 Structural Coverage in Objective Caml by Esterel Technologies

This paper presents a non-intrusive method for Objective Caml code coverage analysis. While classic methods rewrite the source code to an instrumented version that will produce traces at runtime, our approach chooses not to rewrite the source code. Instead, we use a virtual machine to monitor instructions execution and produce traces. These low-level traces are used to create a machine code coverage report. Combined with control-flow debug information, they can be analyzed to produce a source code coverage report. The purpose of this approach is to make available a method to generate code coverage analysis with the same binary for testing and for production. Our customized virtual machine respects the same semantics as the original virtual machine; one of its original aspects is that it is implemented in the Objective Caml, the very language we build the tool for. This work is part of the Coverage project, which aims to develop open source tools for safety-critical embedded applications and their code generators.
POPULATION ASSESSMENT OF THE GRAY WHALE, ESCHRICHTIUS ROBUSTUS, FROM CALIFORNIA SHORE CENSUSES, 1967-80

Estimates of abundance by year were developed for the California-Chukotski stock of gray whales, from a 13­ year consecutive series ofshore censuses, conducted near Monterey, Calif. Annual estimates ofpopulation size range from a low of 10,414 for 1971-72 to a highof17,577 for 1979-80. Standard errors are about 10% of pop­ ulation estimates. During the 13 years censused, the population increased annually by 2.5%, concurrent with a 1.2% harvest in the Soviet subsistence fishery, indicating a 3.7% net annual productivity. Seasonal migratory timing was relatively constant during the study period. Gamma probability density func­ tion models ofthe annual migrations past Monterey had an overall mean day of 9 January, with a range from 8 to 19 January. A slight depression in mean hourly countfor0070-0800 h, during 1978·79 and 1979·80, contrast­ ed with a constant mean hourly count through 10 daylight hours during the previous 11 years. Aerial surveys of the offshore distribution ofsouthward migrating whales during 1979-80 agreed closely with those reported for 1978-79, indicating that 40% pass within 1 mile (1.6 km) of shore and 90% within 2 miles (3.2 km); In the shore censuses, about 20% of the passing whales were missed due to their distance offshore. The estimation of population size for large whales has traditionally been based upon information de­ rived from exploitation, e.g., catch per unit effort, mark-recapture, or related data (Allen 1980). Be­ cause of the recent decline in exploitation of marine mammals, assessment techniques based upon sight­ ing surveys are increasing in importance (Eberhardt et a1. 1979). The annual migration of the California stock of gray whales, Eschrichtius robustus (Lill­ jeborg 1861), makes it especially well suited to assessment by means of sighting surveys. Assess­ ment studies on this stock can potentially aid in the development of sighting survey field and analysis techniques, especially those in which the observer is stationary and the population mobile. This paper presents some recent developments in the use of shore-based census data for whale population as­ sessment, and the results of the 1979-80 gray whale census. Revised population estimates for the pre­ vious 12 annual censuses are also reported, along with a consideration ofchange in population size dur­ ing the period 1967-80. Each year during the northern winter the California stock of gray whales migrates from feeding waters in
SODIUM–OXYGEN ANTICORRELATION AND NEUTRON-CAPTURE ELEMENTS IN OMEGA CENTAURI STELLAR POPULATIONS

Omega Centauri is no longer the only globular cluster known to contain multiple stellar populations, yet it remains the most puzzling. Due to the extreme way in which the multiple stellar population phenomenon manifests in this cluster, it has been suggested that it may be the remnant of a larger stellar system. In this work, we present a spectroscopic investigation of the stellar populations hosted in the globular cluster ω Centauri to shed light on its still puzzling chemical enrichment history. With this aim, we used FLAMES+GIRAFFE@VLT to observe 300 stars distributed along the multimodal red giant branch of this cluster, sampling with good statistics the stellar populations of different metallicities. We determined chemical abundances for Fe, Na, O, and n-capture elements Ba and La. We confirm that ω Centauri exhibits large star-to-star variations in iron with [Fe/H] ranging from ∼−2.0 to ∼−0.7 dex. Barium and lanthanum abundances of metal-poor stars are correlated with iron, up to [Fe/H] ∼−1.5, while they are almost constant (or at least have only a moderate increase) in the more metal-rich populations. There is an extended Na–O anticorrelation for stars with [Fe/H] ≲−1.3 while more metal-rich stars are almost all Na-rich. Sodium was found to mildly increase with iron over the entire metallicity range.
Bergmann s rule in amphibians : combining demographic and ecological parameters to explain body size variation among populations in the common toad Bufo bufo

Large-scale patterns of body size variation are described by well-known generalizations such as Bergmann s rule; the generality and underlying causes of these patterns have been much debated. Intraspecific extension of this rule was tested in various ectotherms, and evidence was found for both Bergmann and converse Bergmann clines. In this study, we explored spatial patterns of variation in a widespread amphibian, the Common toad (Bufo bufo), along a 2240 km latitudinal gradient across Europe. We tested for covariation of adult body size, age and growth parameters with latitude, altitude, length of activity period and mean temperature during this period using both original and literature data. We selected 13 European populations, representing a latitudinal range from 43 to 63 N and altitudinal range from 15 to 1850 m a.s. l. The length of activity period (12–33 weeks) and Tmean (6.6–15.6 C) significantly decreased as latitude and altitude of these populations increased. Mean body size decreased as latitude increased (not with altitude), and increased with Tmean (not with length of activity period). Mean and minimal adult age increased with latitude and altitude, longevity increased with altitude only. Age increased as length of activity period decreased (not with Tmean). The growth coefficient (0.32–0.92 in males, 0.18–0.74 in females, available for six populations) decreased as altitude increased, and increased as both length of activity period and Tmean increased; latitudinal trend was non-significant. Our analysis shows that B. bufo clearly exhibited a converse Bergmann cline along latitudinal gradient, but not along altitudinal gradient; the main effect of elevation was on age. The effects of ecological conditions also differed: body size increased with Tmean, while age parameters were related to the length of activity period. This study highlights that, to identify causal factors underlying general ecogeographical rules, we have to take into account different phases of the life cycle, co-variation among life history traits and ecological factors acting on each of these traits. In amphibians with complex life cycles, lack of appropriate demographical or ecological data may affect our understanding of the variety of observed body size patterns.
Electron-phonon coupling in potassium-doped graphene: Angle-resolved photoemission spectroscopy

The electron-phonon coupling in potassium-doped graphene on Ir(111) is studied via the renormalization of the ${\ensuremath{\pi}}^{\ensuremath{\ast}}$ band near the Fermi level, using angle-resolved photoemission spectroscopy. The renormalization is found to be fairly weak and almost isotropic, with a mass enhancement parameter of $\ensuremath{\lambda}=0.28(6)$ for both the $\overline{K}\ensuremath{-}\overline{M}$ and the $\overline{K}\ensuremath{-}\overline{\ensuremath{\Gamma}}$ direction. These results are found to agree well with recent first-principles calculations.
"Everywhere" and "Here"

ABSTRACT The paper studies propositional logics in a bimodal language, in which the first modality is interpreted as the local truth, and the second as the universal truth. The logic S4UC is introduced, which is finitely axiomatizable, has the f.m. p. and is determined by every connected separable metric space.
B Signaling κ Involvement of Nuclear Factor-: In vivo and In vitro Human Prostate Cancer PC 3 Cells A Dietary Anthocyanidin Delphinidin Induces Apoptosis of Updated

Delphinidin, a major anthocyanidin present in many pigmented fruits and vegetables, possesses antioxidant, antiinflammatory, and antiangiogenic properties. In this study, we provide evidence that it could be developed as a novel agent against human prostate cancer (PCa). We observed that delphinidin treatment to human PCa LNCaP, C4-2, 22RN1, and PC3 cells resulted in a dose-dependent inhibition of cell growth without having any substantial effect on normal human prostate epithelial cells. We selected PC3 cells as a test model system because of their highly aggressive proliferative nature. Delphinidin treatment of cells resulted in a dosedependent induction of apoptosis and arrest of cells in G2-M phase. This induction of apoptosis seems to be mediated via activation of caspases because N-benzyloxycarbonyl-Val-AlaAsp(OMe)-fluromethylketone significantly reduced apoptosis induced by delphinidin. We also observed that delphinidin treatment of cells resulted in a dose-dependent decrease in (a) phosphorylation of IKB kinase ; (NEMO), (b) phosphorylation of nuclear factor-KB (NF-KB) inhibitory protein IKBA, (c) phosphorylation of NF-KB/p65 at Ser and NF-KB/p50 at Ser, (d) NF-KB/p65 nuclear translocation, and (e) NF-KB DNA binding activity. Delphinidin administration (2 mg, i.p. thrice weekly) to athymic nude mice implanted with PC3 cells resulted in a significant inhibition of tumor growth. Analysis of tumors from delphinidin-treated mice showed significant decrease in the expression of NF-KB/p65, Bcl2, Ki67, and PCNA. Taken together, our data suggest that delphinidin could be developed as an agent against human PCa. [Cancer Res 2008;68(20):8564–72]
Demethylation-induced overexpression of Shc 3 drives c-Raf-independent activation of MEK / ERK in HCC Short Title : Shc 3 / MVP / MEK / ERK promotes HCC progress

Invasion and intrahepatic metastasis are major factors of poor prognosis in patients with hepatocellular carcinoma (HCC). In this study, we show that increased Src homolog and collagen homolog 3 (Shc3) expression in malignant HCC cell lines associate with HCC invasion and metastasis. Shc3 was significantly upregulated in tumors of 33 HCC patient samples as compared to adjacent normal tissues. Further analysis of 52 HCC patient samples showed that Shc3 expression correlated with microvascular invasion, cancer staging, and poor prognosis. Shc3 interacted with major vault protein (MVP), resulting in activation of MEK1/2 and ERK1/2 independently of Shc1 and c-Raf; this interaction consequently induced epithelialmesenchymal transition (EMT) and promoted HCC cell proliferation and metastasis. The observed increase in Shc3 levels was due to demethylation of its upstream promoter, which allowed c-Jun binding. In turn, Shc3 expression promoted c-Jun phosphorylation in a positive feedback loop. Analysis of metastasis using a tumor xenograft mouse model further confirmed the role of Shc3 in vivo. Taken together, our results indicate the importance of Shc3 in HCC progression and identify Shc3 as a novel biomarker and potential therapeutic target in HCC. Research. on January 13, 2018. © 2018 American Association for Cancer cancerres.aacrjournals. org Downloaded from Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on January 12, 2018; DOI: 10.1158/0008-5472.CAN-17-2432
Young Children’s Use of ICT in Shanghai Preschools

In the context of ever-increasing presence of information communication technologies (ICT) in young children’s living and educational environments, early childhood education (ECE) policies and curriculum have begun to emphasise the importance of integrating ICT into early childhood practices and provide guidelines for the use of ICT in ECE settings. The current study aims to get a clearer picture of young children’s use of ICT in preschools and develop a better understanding of their experiences with the use of ICT in the classroom. Data were collected from a survey with 316 teachers in 20 public preschools and observations of young children’s ICT activities in two case study classrooms, as part of a larger study. The results show that many children had competences and high interest in using ICT and experienced pleasure and success during their ICT activities, but their overall access to ICT was low, and active and meaningful ICT use was very limited. This paper concludes by suggesting the provision of sufficient reliable hardware and appropriate software for young children to explore the potential of ICT. And EC teachers need to develop effective pedagogies that can support the children’s learning with and through the use of ICT.
Classification of Gene Expression Data by Gene Combination using Fuzzy Logic

The goal of microarray experiments is to identify genes that are differentially transcribed with respect to different biological conditions of cell cultures and samples. Among the large amount of genes presented in gene expression data, only a small fraction of them is effective for performing a certain diagnostic test. Hence, one of the major tasks with the gene expression data is to find groups of co regulated genes whose collective expression is strongly associated with the sample categories or response variables. A framework is improved/ modified in this report to find informative gene combinations and to classify gene combinations belonging to its relevant subtype by using fuzzy logic. The genes are ranked based on their statistical scores and highly informative genes mare filtered. Such genes are fuzzified to identify 2-gene and 3-gene combinations and the intermediate value for each gene is calculated to select top gene combinations to further classify gene lymphoma subtypes by using fuzzy rules. Finally the accuracy of top gene combinations is compared with clustering results. The classification is done using the gene combinations and it is analyzed to predict the accuracy of the results. The work is implemented using java language.