Miracle-dz/UniFAR-FTUs huggingface dataset:
The mitochondrial protein SLC25A43 and it's possible role in HER2-positive breast cancer

The mitochondria have been identified as key players of apoptosis, cell proliferation and cell cycle regulation. However, the role of mitochondria in breast cancer and treatment failure remains unclear. We have previously shown a common deletion of the gene SLC25A43 in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. This gene is coding for a mitochondrial inner membrane transporter and, to date, little is known about the function of this protein. We have also found that low protein expression of SLC25A43 significantly correlates with a lower S phase fraction in HER2-positive breast cancer. The aim of this study was to investigate whether knockdown (KD) of SLC25A43 could have an effect on the cytotoxicity of different cytostatic drugs using MCF10A, MCF7 and BT-474 cells. Following siRNA-mediated KD of SLC25A43, one non-malignant and two breast cancer cell lines were exposed to the anthracycline epirubicin or the taxane paclitaxel. The HER2-positive breast cancer cells were also exposed to the targeted therapy trastuzumab and dual exposure to trastuzumab and paclitaxel. We found that KD of SLC25A43 resulted in a decreased cytotoxic effect of paclitaxel in the two cancer cell lines (P<0.05). Further analysis of cell cycle phase distribution showed that KD increased the paclitaxel-induced G2/M block in these two cell lines (P<0.05). KD of SLC25A43 also reduced the inhibitory effect of trastuzumab on cell proliferation in the HER2-positive cancer cell line BT-474 (P<0.05), and the drug-induced G0/G1 block (P<0.05). Moreover, SLC25A43 influenced the percentage of Ki-67-positive cells. Our findings demonstrate that the mitochondrial protein SLC25A43 affects drug efficacy and cell cycle regulation following drug exposure in breast cancer cell lines.
Enhancing synchrony in multiplex network due to rewiring frequency

Most of the previous studies on synchrony in multiplex networks have been investigated using different types of intralayer network architectures which are either static or temporal. Effect of a temporal layer on intralayer synchrony in a multilayered network still remains elusive. In this paper, we discuss intralayer synchrony in a multiplex network consisting of static and temporal layers and how a temporal layer influences other static layers to enhance synchrony simultaneously. We analytically derive local stability conditions for intralayer synchrony based on the master stability function approach. The analytically derived results are illustrated by numerical simulations on up to five-layers multiplex networks with the paradigmatic Lorenz system as the node dynamics in each individual layer.
Milieuzorg in bedrijven; strategie en organisatie

Geconstateerd wordt dat het wettelijk kader voor het toezicht op de financiering van pensioenaan­ spraken, op zich een groot goed, in Nederland niet bevorderlijk heeft gewerkt voor de ontwikke­ ling en ondersteuning van de jaarverslaggevingspraktijk en dat de internationale ontwikkelingen, vooral die in de Angelsaksische landen, een nieuwe impuls kunnen geven om achterstand in te lopen. Met dit laatste wordt niet gesteld dat die internati­ onale ontwikkelingen tot kopiëring of transplanta­ tie in Nederland moeten leiden, wel dat toekomst­ gerichte waarderingsstelsels veel meer aandacht verdienen dan ze tot heden kregen. Deze stelling geldt wellicht minder de verslaglegging van pen­ sioenfondsen, zeker wel die van de jaarrekenin­ gen van ondernemingen.
Pharmacological, neurochemical and functional characterisation of the MIA model of experimental osteoarthritis

More than 10 million adults consult their GP each year with arthritis and related conditions. Significantly, painful osteoarthritis imposes a much more significant limitation on function than non-­‐painful osteoarthritis. This has lead to a focus on therapies that offer symptomatic relief for sufferers of painful osteoarthritis. Many existing analgesics that are able to partially reduce patients’ pain have undesirable adverse effects when given chronically, especially in elderly patients. Hence the need for greater understanding of the mechanisms involved in osteoarthritis pain, to aid the development of more effective, better-­‐tolerated analgesics. The MIA model of experimental osteoarthritis uses a single intraarticular injection of the metabolic inhibitor monoiodoacetate (MIA) to induce a joint degeneration that closely resembles osteoarthritis. In rats, the model is associated with joint pain that refers to the hindpaw. This PhD thesis presents work characterizing functional plasticity in the MIA model using spinal cord electrophysiology, behavioural pharmacology and immunohistochemistry. The role of spinal and peripheral nerve hyperpolarization-­‐activated cyclic nucleotide gated cation (HCN) channels in osteoarthritis pain was assessed using the HCN channel blocker, ZD7288. These experiments and others using the KCNQ potassium channel blocker XE991, demonstrate novel physiological roles for these ion channels in nociception. Electrophysiology experiments show that the novel analgesic tapentadol, a joint opioid receptor agonist/noradrenaline reuptake inhibitor, is able to reduce nociceptive spinal activity in the MIA model. Lastly, a series of experiments evaluate the biochemically, behaviourally and pharmacologically distinct phenotypes of two variants of the MIA model. The data gathered in this thesis illustrate a number of novel features of this experimental model of osteoarthritis pain, and will inform the development of novel analgesics for osteoarthritis.
Integrating Healthcare with Information and Communications Technology

Part 1: Transforming Healthcare Services Using ICT. Integrating Healthcare. Information Systems (IS) Integration Approaches in Healthcare. Modernizing Healthcare really connecting for health? Integrating Healthcare with ICT. The National Programme for IT (NPfIT): Is there a better way? Part 2: Electronic Health Records. Electronic Records for Patient Centred Healthcare. Integrating Electronic Health Records. Socio-Technical Approaches to EHRs. Part 3: Global ICT Adoption and Implementation in Healthcare. New IT and the Kaiser Chiefs: EMR integration in the Aloha State. Some insights into the National Healthcare Systems of the United Kingdom and the Netherlands. Customer Value and Lean Operations in Healthcare.
The Transmission Mechanism Of Dutch Disease In Nigeria

This study was on the transmission mechanism of Dutch Disease in Nigeria. The term Dutch Disease otherwise known as Hollandis syndrome, came into existence in 1977 when the British Journal titled the Economist first used it. It was used to connote a situation in which discovery of natural gas in large quantity in the Netherland led to mass movement of labour from their industrial sector to their newly discovered gas sector, reduction in agricultural and industrial exports and increase in gas export. This study investigated at least two sources through which Dutch Disease could be transmitted to the Nigerian economy namely: through non-diversification of the economy and through foreign aid received. Data covering the period of 1960 ? 2015 were sourced from the Central Bank Statistical Bulleting and World Development Indicator 2016. Data on Gross Domestic Product (GDP), oil, agriculture, industry and manufacturing sectors were analysed using both the Ordinary Least Squares and the Bayesian Vector Autoregressive techniques and found that the oil sector dominated and relegated agricultural, industrial and especially manufacturing sub-sector of industry to the background. This confirmed existence of Dutch Disease in Nigeria. Data on foreign aid received, import and export and GDP were also analysed using the Bayesian version of autoregressive model and found that as foreign aid received was rising, import was rising and export falling which further confirmed the existence of Dutch Disease in Nigeria. Based on these findings the study recommended (i) diversification of the economy through improved and mechanised agricultural and industrial sector especially the manufacturing sub-sector. (ii) Reduction in foreign aid receive to boost export and decrease import or alternatively to divert such foreign aid to improve our agricultural and industrial productions. (iii) Government should fight corruption by demonetising the over pampered and over monetised political sector of the economy and divert such money to diversify the economy.
Osteoporosis: Diagnosis, Prevention, Therapy

Epidemiology of Osteoporosis. - Biology of Bone. - Pathogenesis of Osteoporosis. - Subgroups of Osteoporosis. - Risk Factors for Fractures. - Clinical Evaluation of Osteoporosis. - Bone Density in Osteoporosis. - Laboratory Evaluation of Osteoporosis. - Prevention of Osteoporosis. - Physical Activity and Exercise Programs. - Treatment Strategies in Osteoporosis. - Management of Pain in Osteoporosis. - Calcium and Vitamin D. - Hormones for Replacement Therapy. - Bisphosphonates. - Selective Oestrogen-Receptor Modulators. - Peptides of the Parathyroid Hormone Family. - Strontium Ranelate. - Calcitonin and Fluoride. - Combination and Sequential Therapies. - Future Directions. - Adherence and Monitoring of Osteoporosis Therapy. - Osteoporotic Fractures. - Pregnancy and Lactation. - Osteoporosis in Men. - Osteoporosis in Children. - Immobilization Osteoporosis. - Osteoporosis in Medical Disciplines. - Osteoporosis and Drugs. - AIDS Osteopathy. - Renal Osteopathy. - Localized Osteopathies. - Periprosthetic Osteoporosis and Aseptic Loosening of Prostheses. - Oral Bone Loss, Periodontitis and Osteoporosis. - Disorders of Bone Due to Tumours. - The Metabolic Syndrome - A Major Cause of Osteoporosis in the World Today.
Flujo sanguíneo cerebral

Entre el 15 y 25% del gasto cardíaco está dirigido al cerebro, con un flujo sanguíneo cerebral (FSC) de 40-50 mL/100 g de tejido cerebral/min. El FSC está determinado por el consumo metabólico de oxígeno cerebral (CMRO2), influida por la autorregulación mediante la resistencia vascular cerebral (RVC), y por la presión de perfusión cerebral (PPC), que es la diferencia entre la PAM y la PIC(1,2). El CMRO2 corresponde, en un 40%, al gasto energético basal (en su mayor parte para mantener el potencial de membrana, por lo que no es modificable por fármacos pero sí termosensible) y en un 60% al gasto energético funcional (no termosensible pero sí modificable por fármacos). El 90% de este CMRO2 corresponde al tejido neuronal y sólo un 10% al tejido de sostén o glía (el cual supone más del 50% del volumen encefálico). El CMRO2 se encuentra entre 4-6 mL/100 g de tejido cerebral/min. Así, situaciones patológicas como la anemia o la hipoxia reducirán el contenido arterial de oxígeno, pudiendo determinar una entrega cerebral de oxígeno inadecuada(1). La autorregulación cerebral se basa en la modificación de la RVC (vasodilatación o vasoconstricción) con el fin de mantener un FSC acorde a las necesidades metabólicas cerebrales de O2 de cada momento. Está determinada en gran parte por la presión parcial arterial de dióxido de carbono (PaCO2), por la PAM y, en menor medida, por la presión parcial arterial de oxígeno, la adenosina, el pH, etcétera. Así, cuando la PaCO2 cerebral es alta (mayor trabajo metabólico), la RVC cae (vasodilatación), aumentando el FSC y la entrega cerebral de oxígeno (CDO2). Lo contrario ocurre cuando la PaCO2 disminuye (menor trabajo metabólico; vasoconstricción). Se estima que el FSC varía en un 4% por cada mmHg de CO2, en normotensión. Con la PAM ocurre algo similar, regulándose el FSC para proteger al tejido cerebral de caídas o alzas bruscas de presión que pudiesen comprometer la CDO2. Sin embargo, estas autorregulaciones tienen límites por encima o por debajo de los cuales el FSC se torna absolutamente dependiente de la PAM(3). En la figura 1 se resumen los principales mecanismos que afectan el flujo sanguíneo cerebral. Existen diversos métodos para la valoración del flujo sanguíneo cerebral, entre los cuales se encuentran:
Pregestational Diabetes and Congenital Heart Defects: Role of Reactive Oxygen Species

ii Co-Authorship Statement . iv Acknowledgment . v Table of Content . vii List of Tables . xiii List of Figures . xiv List of Appendices . xvii List of Abbreviations, Symbols and Nomenclature . xviii 1 CHAPTER 1 . 1 1.1 PREGESTATIONAL DIABETES . 1 1.2 HEART DEVELOPMENT . 2 1.2.1 Origin of Heart Fields . 3 1.2.2 Heart looping . 4 1.2.3 Septation of Ventricles and Atria . 6 1.2. 4 Septation of the Outflow Tract . 9 1.2. 5 Physiology of Fetal Heart . 9 1.2. 6 Molecular Regulators of Early Heart Development . 10 1.2. 7 Transcription Factor Interactions . 13 1.2. 8 Regulators of Endocardial Cushion Development . 14 1.2. 9 Morphological Aspect of Coronary Artery Development . 17 1.2.10 Molecular Regulators of Coronary Artery Development . 20 viii 1.3 CONGENITAL HEART DEFECTS . 22 1.3. 1 Genetics and Environmental Basis of CHDs . 22 1.3. 2 Types of Congenital Heart Defects . 23 1.3. 3 Atrial Septal Defects . 23 1.3. 4 Ventricular Septal Defects . 24 1.3. 5 Atrioventricular Septal Defects . 25 1.3. 6 Tetralogy of Fallot . 26 1.3. 7 Dextro-Transposition of the Great Arteries . 27 1.3. 8 Double Outlet Right Ventricle . 28 1.3. 9 Hypoplastic coronary artery disease . 28 1.4 Mechanism of CHDs in Pregnancies Affected by Diabetes . 29 1.4. 1 ROS Regulation of Growth and Development . 31 1.4. 2 Glutathione and Its Precursor N-Acetylcysteine . 32 1.5 OVERALL HYPOTHESIS AND AIMS . 34 1.6 REFERENCES . 38 2 Chapter 2 . 57 2.1 CHAPTER SUMMARY . 58 2.2 INTRODUCTION . 59 2.3 METHODS . 60 2.3. 1 Animals . 60 2.3. 2 Induction of Diabetes Mellitus and N-Acetylcysteine Treatment . 60 2.3. 3 Histological Analysis . 61 2.3. 4 Analysis of Superoxide Levels . 62
Essential nursing skills : clinical skills for caring

1 Infection prevention and control 2 Observation and monitoring 3 Resuscitation 4 Vascular access and intravenous therapy 5 Blood transfusion 6 Nutrition and hydration 7 Medicines management 8 Elimination 9 Peri-operative Care 10 Patient hygiene 11 Respiratory care 12 Reduced mobility
Produce Safety, Perceived Risk, and Consumer Choice

Virginia Cooperative Extension programs and employment are open to all, regardless of age, color, disability, gender, gender identity, gender expression, national origin, political affiliation, race, religion, sexual orientation, genetic information, veteran status, or any other basis protected by law. An equal opportunity/affirmative action employer. Issued in furtherance of Cooperative Extension work, Virginia Polytechnic Institute and State University, Virginia State University, and the U.S. Department of Agriculture cooperating. Edwin J. Jones, Director, Virginia Cooperative Extension, Virginia Tech, Blacksburg; M. Ray McKinnie, Administrator, 1890 Extension Program, Virginia State University, Petersburg. Produce Safety, Perceived Risk, and Consumer Choice
Diversification Benefits, Where Art Thou?

Following the global financial crisis, a portfolio concentrated in US large cap equity and aggregate fixed income has provided higher returns than diversified portfolios through 2019. Such a prolonged experience causes investors to question the benefits of diversification. This leads us to use a longer history of data across 15 asset classes to understand the historical benefits of diversifying a portfolio with international equity, real assets, and below-investment-grade fixed income. The authors’ results portray the frequency and magnitude of risk-adjusted return improvement coming from different diversifying asset classes over five-year holding periods. The authors find that certain asset classes, such as below-investment-grade fixed income, regularly improve risk-adjusted return of the portfolio, while other asset classes like commodities improve risk-adjusted returns less frequently. Further, they observe that some asset classes do not deliver meaningful risk-adjusted return improvements in the presence of other asset classes. Their conclusion is that investors should continue to build diversified portfolios, but in doing so they should consider that some asset classes more consistently improved risk-adjusted returns than others. TOPICS: Wealth management, retirement, fixed-income portfolio management Key Findings • Certain asset classes, such as below-investment-grade fixed income, have provided consistent diversification benefits through time, while other asset classes, such as commodities (despite its low correlation to other asset classes), have less frequently improved portfolio performance. • Some asset classes have not delivered meaningful portfolio diversification benefits in the presence of other asset classes during the periods we examined. • We observe cyclicality in the improvement of portfolio returns from holding a more diversified portfolio. The periodicity appears longer than the US business cycle. Moreover, the time series of relative price-to-earnings ratios of US and international equity appears to move countercyclically with the outperformance of diversified portfolios.
Towards Integrated Peacebuilding: Comprehensively Integrating Psychosocial Factors in Peacebuilding Trainings and Programmes for Increased Impact

The need for more extensive and practical self-care and professional care for peacebuilders: Peacebuilding practitioners are often working under extremely challenging conditions, which often lead to stress, tension, and reduced productivity, but also to burn-out, depression, or substance abuse. The impact this has upon the quality of peacebuilders’ work is often underestimated. Front-line workers need to be supported in maintaining their own well-being but have rarely been trained or educated in practical stress and self-management tools to effectively handle this aspect of peacebuilding work. This has been repeatedly confirmed by International Association for Human Values’ (IAHV) engagements in conflict zones around the world, including by the attendees of IAHV’s workshop at the conference “Shaping the Future of Peace Training in Europe and Beyond” in Vienna, October 1–2, 2018.
Security Issues and Challenges on Wireless Sensor Networks

Wireless Sensor Networks (WSNs) are emerging as a rich field of active research that is involved different aspects. Nowadays, sensors are used in many domains as applications that can monitor and control. These domains include applications such as environmental, home, commercial, military, health, etc. WSNs are used in numerous applications that involves sensitive information needs to be secure and confidential. Especially in applications that deal with top secret information such as military applications. Therefore, the important of security issues in WSNs have received potential attention from designers, developers, and security professionals. Moreover, this type of network is highly vulnerable to numerous security attacks due to its resource constraints and mobility. This paper gives comprehensive details in WSN constraints, vulnerabilities, and security attacks. In addition, the paper investigates the recent countermeasures that are used to counter WSN attacks in terms of their achievements and limitations. The paper concludes that security is the key to success for WSN applications, However, still many critical security problems are remained unsolved. Moreover, when designing an adequate security solution; productivity, usability, mobility, resource constraints and privacy preservation should all be taken into account. Therefore, a huge challenge still facing researchers and designers to bring up sufficient solutions to secure WSN applications.
ABC of clinical electrocardiography

Preface. 1 Introduction. I-Leads, Rate, Rhythm and Cardiac Axis: Steve Meek (Royal United Hospitals, Bath), Francis Morris (Northern General Hospital, Sheffield). 2 Introduction. II-Basic Terminology: Steve Meek (Royal United Hospitals, Bath), Francis Morris (Northern General Hospital, Sheffield). 3 Bradycardias and Atrioventricular Conduction Block: David Da Costa (Northern General Hospital, Sheffield), William J Brady (University of Virginia), June Edhouse (Stepping Hill Hospital, Stockport). 4 Atrial Arrhythmias: Steve Goodacre (University of Sheffield), Richard Irons (Princess of Wales Hospital, Bridgend). 5 Junctional Tachycardias: Demas Esberger (Queen's Medical Centre, Nottingham), Sallyann Jones (Queen's Medical Centre, Nottingham), Francis Morris (Northern General Hospital, Sheffield). 6 Broad Complex Tachycardia-Part I: June Edhouse (Stepping Hill Hospital, Stockport), Francis Morris (Northern General Hospital, Sheffield). 7 Broad Complex Tachycardia-Part II: June Edhouse (Stepping Hill Hospital, Stockport), Francis Morris (Northern General Hospital, Sheffield). 8 Acute Myocardial Infarction-Part I: Francis Morris (Northern General Hospital, Sheffield), William J Brady (University of Virginia). 9 Acute Myocardial Infarction-Part II: June Edhouse (Stepping Hill Hospital, Stockport), William J Brady (University of Virginia), Francis Morris (Northern General Hospital, Sheffield). 10 Myocardial Ischaemia: Kevin Channer (Royal Hallamshire Hospital, Sheffield), Francis Morris (Northern General Hospital, Sheffield). 11 Exercise Tolerance Testing: Jonathan Hill (Barts and the London NHS Trust), Adam Timmis (London Chest Hospital). 12 Conditions Affecting the Right Side of the Heart: Richard A Harrigan (Temple University School of Medicine, Philadelphia), Kevin Jones (Bolton Royal Hospital). 13 Conditions Affecting the Left Side of the Heart: June Edhouse (Stepping Hill Hospital, Stockport), R K Thakur (Michigan State University), Jihad M Khalil (Michigan State University). 14 Conditions not Primarily Affecting the Heart: Corey Slovis (Vanderbilt University Medical Center), Richard Jenkins (Northern General Hospital, Sheffield). 15 Paediatric Electrocardiography: Steve Goodacre (University of Sheffield), Karen McLeod (Royal Hospital for Sick Children, Glasgow). 16 Cardiac Arrest Rhythms: Robert French (Medical College of Wisconsin), Daniel DeBehnke (Medical College of Wisconsin), Stephen Hawes (Wythenshaw Hospital, Manchester). 17 Pacemakers and Electrocardiography: Richard Harper (Temple University Hospital, Philadelphia), Francis Morris (Northern General Hospital, Sheffield). 18 Pericarditis, Myocarditis, Drug Effects, and Congenital Heart Disease: Chris A Ghammaghami (University of Virginia), Jennifer H Lindsey (University of Virginia Health System). Self Assessment Quiz. Index
Monetary Policy and Bank Equity Values in a Time of Low and Negative Interest Rates

Does banks' exposure to interest rate risk change when interest rates are very low or even negative? Using a high-frequency event study methodology and intraday data, we find that the effect of surprise interest rate cuts announced by the ECB on European bank equity values ? an effect that is normally positive ? has become negative since interest rates in the euro area reached zero and below. Since then, a further unexpected cut of 25 basis points in the short-term policy rate lowered banks' stock prices by about 2% on average, compared to a 1% increase in normal times. In the cross section, this 'reversal' was far more pronounced for banks with a more traditional, deposit-intensive funding mix. We argue that the reversal as well as its cross-sectional pattern can be explained by the zero lower bound on interest rates on retail deposits.