Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of Mouse Short-chain Aldehyde Reductase (SCALD), an Enzyme Regulated by Sterol Regulatory Element-binding Proteins*

Sterol regulatory element-binding proteins (SREBPs) enhance transcription of genes encoding all of the proteins required for the cellular synthesis and uptake of cholesterol and unsaturated fatty acids. Here, we use suppression subtractive hybridization to identify a previously unrecognized SREBP-enhanced gene in mice. The gene encodes a membrane-bound enzyme that we designate SCALD, for short-chain aldehyde reductase. We expressed SCALD in bacteria, purified it extensively, and studied its catalytic properties in detergent solution. The enzyme specifically uses NADPH to reduce a variety of short-chain aldehydes, including nonanal and 4-hydroxy-2-nonenal. The enzyme also reduces retinaldehydes, showing equal activity for all-trans-retinal and 9-cis-retinal. Northern blot analysis indicates that SCALD is expressed most abundantly in mouse liver and testis. In the liver of mice, SCALD is suppressed by fasting and induced by refeeding, consistent with regulation by SREBPs. In testis, SCALD expression is restricted to pachytene spermatocytes, as revealed by visualization of mRNA and protein. SCALD is also expressed in four layers of the retina, including the outer segment of rods and cones, as revealed by immunohistochemistry. SCALD appears to be the mouse ortholog of the human protein that has been designated variously as prostate short-chain dehydrogenase/reductase 1, retinal reductase 1, and retinol dehydrogenase 11. In view of its ability to reduce short-chain aldehydes in addition to retinals, we propose that SCALD may be induced by SREBP in liver and other tissues to prevent toxicity from fatty aldehydes that are generated from oxidation of unsaturated fatty acids that are synthesized as a result of SREBP activity.
Low Neonatal Birth Weight as a Possible Predictive Factor for the Onset of Postpartum Eclampsia

Objective. To report about a case of complicated late postpartum eclampsia where neonatal low birth weight could be considered a predictive factor of placental sufferance. Methods. A 25-year-old woman, without medical or familiar history for hypertension or cerebrovascular diseases, underwent a normal spontaneous delivery with neonatal birth weight of 2340 g (9th percentile). Eight days later the patient presented sudden headache and generalized tonic–clonic seizures. Results. Blood hypertension and alterations in laboratory studies were detected; a diagnosis of late postpartum eclampsia was made. A CT scan showed subarachnoid hemorrhage (Hunt and hess grade I, Fisher grade III). Serial cerebral angiograms did not show any intracranial vascular malformations; epilepsy and hypertension were successfully medically treated; and a repeat CT examination showed the gradual resolution of subarachnoid hemorrhage. Headache progressively disappeared. Conclusions. Low neonatal birth weight could be linked to placental dysfunction and considered as a predictive factor for the onset of postpartum preeclampsia/eclampsia. We recommend a careful clinical and laboratory management of puerperium up to the first month postpartum, in particular in cases of “sine causa” neonatal low birth weight.
Excitatory amino acid receptors and synaptic transmission in the rat ventrobasal thalamus.

1. Extracellular single‐neurone recordings were made in the ventrobasal thalamus (v.b.t.) of urethane‐anaesthetized rats with multi‐barrel ionophoretic electrodes in order to test the hypothesis that excitatory amino acid receptors are involved in the responses of these neurones to stimulation of sensory afferents. 2. Responses of neurones to either physiological stimulation of hair and vibrissa follicle sensory afferents and to ionophoretically applied excitatory amino acids were challenged with the antagonists D‐2‐amino‐5‐phosphonovalerate (APV), kynurenate and gamma‐D‐glutamylaminomethyl sulphonate (GAMS). 3. In agreement with previous findings in other brain areas, ionophoretically applied APV was found to selectively antagonize responses of v.b. t. neurones to N‐methylaspartate (NMA), whereas GAMS was found to be moderately kainate selective. Kynurenate was found to be relatively non‐selective. 4. Responses of neurones to short‐duration (10‐20 ms) physiological stimulation of afferents were resistant to APV when this antagonist was applied with NMA‐selective ionophoretic currents. In contrast, these APV currents were adequate to antagonize responses to maintained physiological stimulation. 5. The broad spectrum excitatory amino acid antagonist kynurenate was found to block synaptic responses of v.b. t. neurones to both short‐duration and maintained stimuli when it was applied with currents which were sufficient to reduce responses to ionophoretic quisqualate. 6. GAMS was found to selectively block kainate responses in a proportion of the neurones tested. In such cases, there was little effect of the antagonist on the responses evoked by either short‐duration or maintained sensory stimuli. 7. It is concluded that excitatory amino acid receptors of both the NMDA and non‐NMDA type are involved in the synaptic responses of v.b. t. neurones to sensory afferent stimulation, and that the apparent synaptic pharmacology depends on the mode of stimulation of the afferent pathway.
The Study of Following Behavior to Bi-direction Pedestrian Flow with the Dynamic Preconscious Effect

Abstract In view of the preconscious behavior of pedestrian and walking speed differences, a lattice gas model of bi-direction pedestrian flow is established in this paper. According to the characteristics of pedestrian following behavior and preconscious dynamic change in different walking conditions, bi-direction pedestrian behavior model based on dynamic preconsciousness is constructed to study the bias decision-making behavior of pedestrian movement. Through numerical simulation, the influence of regional size, asymmetry and speed deviation on the Bi-direction pedestrian flow is analyzed. Results indicate that dynamic preconscious behavior enhances the stability of the system and reduces pedestrian congestion. The passing behavior of the high-speed pedestrian is the main cause for the congestion in the situation of high density. The speed difference will largely influence the anti-congestion ability of the system, so keeping the unity of the speed and group order would maintain the stability and the anti-congestion ability of the system for the whole system.
Worker Adaptation and Employer Accommodation Following the Onset of a Health Impairment

The responses of workers and their employers to the onset of work-limiting health impairments were investigated using data from the new Health and Retirement Study. The results indicate that many workers who suffer from health limitations are directly accommodated by their employers, and that those those who do not receive direct accommodation frequently adapt to their limitations by altering their job demands or by changing jobs. These findings point to the potential for adjustments on both sides of the market: by employers, in the form of job accommodation, and by employees, in the form of job change.
Software for camera calibration and 3D points reconstruction in stereophotogrammetry

This paper deals with the problem of a camera calibration for a photogrammetry and computer vision purposes. Mathematic formulation of the 3D point representation in an external space and its transformation into 2D image space is exposed. The pinhole camera model is used for a problem simplification The camera calibration problem represents intrinsic and extrinsic parameters determination. The stereo correspondence problem is outlined also. Finally the designed special software (Recon3D) for 3D reconstruction is presented.
Ultra-low power and ultra-low voltage devices and circuits for IoT applications

This paper reports new device trends of ultra-low power, ultra-low leakage, and ultra-low voltage for IoT applications. The SOTB technology achieves subthreshold leakage as low as 0.2pA/μm. Some device/circuit tricks for non-volatility and ultra-low voltage operation are reviewed.
A non‐invasive tape absorption method for recovery of inflammatory mediators to differentiate normal from compromised scalp conditions

Background/aims: A simple non‐invasive tape (SebutapeTM) adsorption method was used to recover inflammatory proteins from normal and compromised human scalp (i.e. dandruff and seborrheic dermatitis) in order to assess the inflammatory and immunologic changes relevant to these clinical conditions.
“It’s Complicated”—Sex Differences in Perceptions of Cross-Sex Friendships

ABSTRACT Surprisingly, little is known about how a person’s sex relates to beliefs about cross-sex friendships. In this study, participants completed a survey in which they provided separate estimates for the percentage of cross-sex friendships that contained secret “female-on-male” and “male-on female” sexual interest, indicated their optimism in the idea that males and females could be “just friends,” and reported their comfort with their partner forming a cross-sex friendship. Males were just as optimistic as females about the possibility and indicated similar levels of discomfort in response to imagining their partner entering into a cross-sex friendship. Furthermore, males did not provide higher estimates of sexual interest in cross-sex friendships compared to females. Instead, a more nuanced pattern emerged. Males (vs. females) provided higher estimates of male-to-female sexual interest, but females (vs. males) provided higher estimates of female-to-male sexual interest.
Use of wheelchairs and other mobility support devices.

Health Reports, Vol. 15, No. 3, May 2004 Statistics Canada, Catalogue 82-003 About 155,000 Canadians who were living in private households in 2000/01 needed a wheelchair to get around. This represents 0.6% of the total household population aged 12 or older (Table A). An additional 540,000 individuals (2.1%) needed other devices such as braces, canes or crutches. These figures on the use of “mobility support devices” in the household population are from the first cycle of the Canadian Community Health Survey, a general health survey conducted by Statistics Canada between September 2000 and October 2001.
Dietary anthocyanins as a complementary medicinal approach for management of inflammatory bowel disease

Inflammatory bowel disease (IBD) is thought to result from a chronic or relapsing activation of the immune system in the GI tract. A growing body of evidence confirms the health benefits of dietary anthocyanins as plant-derived natural agents. The aim of this review is to provide an overview of several natural products rich in anthocyanins used worldwide for the treatment of IBD. Anthocyanins possess both protective and therapeutic functions in the management of IBD by alleviating oxidative stress processes, cytoprotective functions, downregulation of inflammatory cytokines and suppressing cellular signaling pathways of inflammatory processes. In conclusion, the consumption of anthocyanin-rich natural formulations must be promoted on the basis of their possible function in the prevention and treatment of gastrointestinal inflammatory disorders.
Anxiety and depression in patients with chronic obstructive pulmonary disease (COPD). A review

A review of the literature revealed high comorbidity of chronic obstructive pulmonary disease (COPD) and states of anxiety and depression, indicative of excess, psychiatric morbidity in COPD. The existing studies point to a prevalence of clinical significant symptoms of depression and anxiety amounting to around 50%. The prevalence of panic disorder and major depression in COPD patients is correspondingly markedly increased compared to the general population. Pathogenetic mechanisms remain unclear but both psychological and organic factors seem to play a role. The clinical and social implications are severe and the concurrent psychiatric disorders may lead to increased morbidity and impaired quality of life. Furthermore, the risk of missing the proper diagnosis and treatment of a concurrent psychiatric complication is evident when COPD patients are treated in medical clinics. Until now only few intervention studies have been conducted, but results suggest that treatment of concurrent psychiatric disorder leads to improvement in the physical as well as the psychological state of the patient. Panic anxiety as well as generalized anxiety in COPD patients is most safely treated with newer antidepressants. Depression is treated with antidepressants according to usual clinical guidelines. There is a need for further intervention studies to determine the overall effect of antidepressants in the treatment of anxiety and depression in this group of patients.
Mitigation of Imperfect Carver-Induced Phase Distortions in a Coherent PM-RZ-QPSK Receiver

The impact of phase distortions caused by imperfect return-to-zero (RZ) pulse carving on 112 Gb/s polarization-multiplexed (PM)-RZ-quadrature-phase-shift-keying (QPSK) is investigated, and mitigation of the phase distortion is demonstrated by using digital signal processing technique. We show that carver-induced phase distortion causes an error in frequency offset estimation as well as sensitivity degradation. Based on the periodicity of distortion pattern, the phase distortion is compensated by estimating mean phase distortions for even and odd symbols after block phase estimation and subtracting these values from original symbols. The optical SNR penalty measured at 112 Gb/s PM-RZ-DQPSK signal is reduced from 3.8 to 1.1 dB with the help of correction algorithm.
Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene.

Introduction of the Herpes simplex virus thymidine kinase (HSV-tk) gene into target cells renders them susceptible to killing by ganciclovir (GCV). We are studying the use of HSV-tk-transduced T lymphocytes in the context of hematopoietic stem cell transplantation. We have previously shown, in vitro and in vivo, the occurrence of transduced cells resistant to GCV due to a deletion within HSV-tk. This deletion, a consequence of the presence of cryptic splice donor and acceptor sites, originates in the retroviral producer cell. Here we adopt two different methods that introduce third-base degenerate changes at the cryptic splice sites and so prevent splicing. Consequently, the HSV-tk protein is unaltered and the sensitivity of the target cells to GCV is preserved. The use of this mutated HSV-tk should reduce the likelihood of the development of resistant genetically modified cells during clinical trials.
Aperture fed wideband circularly polarized rectangular stair shaped dielectric resonator antenna

A circularly polarized rectangular stair shaped dielectric resonator antenna (DRA) is presented. The DRA is excited by a narrow rectangular slot and rotated 45/spl deg/ with respect to the sides of the DRA to generate circular polarization. A parametric study of the length to width ratio to optimize the axial ratio bandwidth is given. A 3 dB axial ratio bandwidth of 10.6% is achieved when the length to width ratio is 1.9.
A New Model for Converting Short Span Compression with Other Measurements to Ring Crush

Linerboard and medium for corrugated packaging has been traditionally marketed on the basis of Ring Crush (RCT) specifications. The current industry trend has replaced manual testing by automated in-line testing which excludes RCT but has basis weight, an ultrasonic stiffness index (TSI), and short span compression (SCT) commonly available. This paper shows how using a combination of these measurements with a non-linear mechanistic theory, equivalent RCT values can be calculated with a good reliability. The model is applied using a wide range of medium and linerboards obtained from 2 mills.
Wireless for peripheral nerve prosthesis and safety

Plethora of implant devices reported in the last decade are enabled using wireless power delivery and telemetry systems. In this work, we present the design of wireless a platform that enables a completely implantable peripheral nerve prosthesis. Large power (over 100mW) delivery and large bandwidth telemetry (1.3 Mbps) demanded by this prosthesis application are addressed by the proposed platform whilst still adhering to the regulatory specific absorption rate safety limits (2W/Kg). The wireless platform is built and verified using acute rodent experiments.
The Swedish Knee Arthroplasty Project

25 years ago, members of the Swedish Orthopedic Society, at a meeting in Uppsala, initiated a nationwide multicenter study which should monitor endoprosthetic knee surgery prospectively. The project evolved into the creation of a database, later known as the Swedish Knee Arthroplasty Register (SKAR), the oldest national arthroplasty register. It was a success and comprised more than 65,000 primary knee arthroplasties, with their revisions, at the end of 1999.
Evaluation of an adaptive power and error control algorithm for wireless systems

We study the performance of a unified power control and forward error correction control algorithm for mobile radio systems that attempts to maximize system capacity and minimize transmitter power utilization while satisfying user defined quality of service constraints. The algorithm is distributed, with each individual transmitter-receiver pair determining its own operating point with respect to power and error control parameters. Simulation results from a cellular system with mobile users show that this unified algorithm outperforms the schemes that use power control alone.
Optimization techniques for dynamic behavior modeling of digital CMOS VLSI circuits in nanometric technologies

In the field of logic simulation, the constant advance of technology influences remarkably in the circuits dynamic behavior. Our main aim is to increase precision of logic simulators by taking into account this influence. This task has two main objectives: (a) developing a model for logic gates that unifies the functional behavior and the dynamic one and (b) developing techniques that improve the characterization processes by using accurate and feasible characterization methods to reduce the error introduced during parameters extraction. The first task has yielded to develop the Internode model, what is based on a finite state machine that represents the internal state of the gate depending on the electrical local of its internal nodes. Such model allows simulators to take into account all the power consumption cases (not only the usually considered ones). On the second task, we have developed a characterization technique based on the use of sampled signals. This technique has improved measurement precision by 5%-8% in the SCMOS inverter case (350 nm technology).
Effects of daily oral administration of rifaximin and neomycin on faecal aerobic flora in rats.

The aim of this study was to compare the influence of rifaximin and neomycin on faecal flora in rats. The study was performed on 18 Wistar rats (three groups of six male animals). Group 1 received rifaximin (50 mg kg(-1)/day), group 2, neomycin (50 mg kg(-1)/day) and group 3 was used as control. Drugs were administered orally, once daily for 3 days. Faecal specimens, collected from each rat on day 3, were cultured for the quantitative and qualitative determination of aerobic microorganisms. Rifaximin treatment produced a marked reduction in the number of total aerobic bacteria and Salmonellae; neomycin caused reduction in Salmonellae, but did not cause statistically significant changes in total aerobic bacterial count. The binding of neomycin with faeces could explain this limited activity, which does not correlate with the in vitro susceptibility of the organism affected. These results confirm that rifaximin is suitable for topical treatment to reduce selected bacterial load in the gut intestines.
Stock market analysis from Twitter and news based on streaming big data infrastructure

Due to the rapid development of the web, services of social media and Internet of Things (IoT) are producing a huge volume of data in every second. This data is not only large, but also grows quickly and is difficult to analyze. Most of traditional big data framework can't process such data in real-time. For processing the data in real-time, many companies and researchers have started to develop new big data frameworks. The Apache Spark, Apache Flink and Apache Storm have been introduced for real-time data processing. With the new processing frameworks, it has become more efficient to analyze the streaming data. Stock market analysis is a hot issued domain to analyze the big streaming data. In this paper, we build a real-time processing system to analyze tweets for finding correlation with the stock market. System configuration, performance of our system is explained. With 77% accuracy of Twitter data classification, we got 80% of separation of increase/decrease of stock value.
Towards a computational theory of definite anaphora comprehension in English discourse

Abstract : This report investigates the process of focussing as a description and explanation of the comprehension of certain anaphoric expressions in English discourse. The investigation centers on the interpretation of definite anaphora, that is, on the personal pronouns, and noun phrases used with a definite article the, this, or that. Focussing is formalized as a process in which a speaker centers attention on a particular aspect of the discourse. An algorithmic description specifies what the speaker can focus on and how the speaker may change the focus of the discourse as the discourse unfolds. The algorithm allows for a simple focussing mechanism to be constructed: an element in focus, an ordered collection of alternate foci, and a stack of old foci. The data structure for the element in focus is a representation which encodes a limited set of associations between it and other elements from the discourse as well as from general knowledge. This report also establishes other constraints which are needed for the successful comprehension of anaphoric expressions. The focussing mechanism is designed to take advantage of syntactic and semantic information encoded as constraints on the choice of anaphora interpretation. These constraints are due to the work of language researchers; and the focussing mechanism provides a principled means for choosing when to apply the constraints in the comprehension process.
Preliminary Observations on the Ability of Hyperspectral Imaging to Provide Detection and Visualization of Bloodstain Patterns on Black Fabrics

Abstract: The analysis of bloodstain patterns can assist investigators in understanding the circumstances surrounding a violent crime. Bloodstains are routinely subjected to pattern analysis, which is inherently dependent upon the ability of the examiner to locate and visualize bloodstain patterns on items of evidence. Often, the ability to properly visualize bloodstain patterns is challenging, especially when the stain patterns occur on dark and/or patterned substrates. In this study, preliminary research was performed to better understand how near‐infrared reflectance hyperspectral imaging (HSI) could be used to observe bloodstain patterns on commonly encountered black fabrics. The ability of HSI to visualize latent bloodstains on several commonly encountered substrates is demonstrated. The images acquired through HSI are of sufficient quality to allow for differentiation between stains produced from an impact mechanism or a transfer mechanism. This study also serves as a proof of concept in the differentiation of multiple staining materials. Because of its ability to generate spectral data, the data provide a preliminary separation of stains where more than one type of stain existed.