Miracle-dz/UniFAR-FTUs huggingface dataset:
Project Synergy: co‐designing technology‐enabled solutions for Australian mental health services reform

Project Synergy aims to test the potential of new and emerging technologies to enhance the quality of mental health care provided by traditional face‐to‐face services. Specifically, it seeks to ensure that consumers get the right care, first time (delivery of effective mental health care early in the course of illness). Using co‐design with affected individuals, Project Synergy has built, implemented and evaluated an online platform to assist the assessment, feedback, management and monitoring of people with mental disorders. It also promotes the maintenance of wellbeing by collating health and social information from consumers, their supportive others and health professionals. This information is reported back openly to consumers and their service providers to promote genuine collaborative care. The online platform does not provide stand‐alone medical or health advice, risk assessment, clinical diagnosis or treatment; instead, it supports users to decide what may be suitable care options. Using an iterative cycle of research and development, the first four studies of Project Synergy (2014–2016) involved the development of different types of online prototypes for young people (i) attending university; (ii) in three disadvantaged communities in New South Wales; (iii) at risk of suicide; and (iv) attending five headspace centres. These contributed valuable information concerning the co‐design, build, user testing and evaluation of prototypes, as well as staff experiences during development and service quality improvements following implementation. Through ongoing research and development (2017–2020), these prototypes underpin one online platform that aims to support better multidimensional mental health outcomes for consumers; more efficient, effective and appropriate use of health professional knowledge and clinical skills; and quality improvements in mental health service delivery.
Outcomes of splanchnic vein thrombosis in patients with myeloproliferative neoplasms in a single center experience

Myeloproliferative neoplasms (MPNs) are a group of hematologic malignancies characterized by overlapping clinical features including an increased thrombotic potential. Splanchnic vein thrombosis (SVT) has a known association with MPNs, in which 8.2% of SVTs occur in the setting of an underlying MPN. A main consequence of SVT is portal hypertension, which can lead to complications including esophageal variceal bleeding (EVB) and ascites. The impact of treating the underlying MPN at time of SVT on these hepatic outcomes is unknown.
N-glycosylation of the CmeABC multidrug efflux pump is needed for optimal function in Campylobacter jejuni.

Campylobacter jejuni is a prevalent gastrointestinal pathogen associated with increasing rates of antimicrobial resistance development. It was also the first bacterium demonstrated to possess a general N-linked protein glycosylation pathway capable of modifying >80 different proteins, including the primary Campylobacter multidrug efflux pump, CmeABC. Here we demonstrate that N-glycosylation is necessary for the function of the efflux pump and may, in part, explain the evolutionary pressure to maintain this protein modification system. Mutants of cmeA in two common wildtype strains are highly susceptible to erythromycin, ciprofloxacin and bile salts when compared to the isogenic parental strains. Complementation of the cmeA mutants with the native cmeA allele restores the wildtype phenotype, whereas expression of a cmeA allele with point mutations in both N-glycosylation sites is comparable to the cmeA mutants. Moreover, loss of CmeA glycosylation leads to reduced chicken colonization levels similar to the cmeA knock-out strain, while complementation fully restores colonization. Reconstitution of C. jejuni CmeABC into Escherichia coli together with the C. jejuni N-glycosylation pathway increases the erythromycin minimum inhibitory concentration and decreases ethidium bromide accumulation when compared to cells lacking the pathway. Molecular dynamics simulations reveal that the protein structures of the glycosylated and non-glycosylated CmeA models do not vary from one another, and in vitro studies show no change in CmeA multimerization or peptidoglycan association. Therefore, we conclude that N-glycosylation has a broader influence on CmeABC function most likely playing a role in complex stability.
The Frequency and Risk Factors of Delayed Graft Function in living Donor Kidney Transplantation and Its Clinical Impact on Graft and Patient Survival in Part of Middle East.

Delayed graft function (DGF) is a form of acute renal failure which results in increased post-transplantation allograft immunogenicity and risk of acute rejection episodes in addition to decreased long-term survival. Its incidence and risk factors have been extensively studied, especially after deceased donation. Until now, only few data has been published on DGF in living donor kidney transplant recipients. The present study was performed to investigate the frequency and risk factors of DGF among living- kidney transplant recipients. In this retrospective study, data had been collected from existing local hospital registries in three countries (Iran, Kingdom of Saudi Arabia (KSA) , and Kuwait ).
West-Central African Pleistocene lowland forest evolution revealed by the phylogeography of Misonne’s soft-furred mouse

We studied the phylogeographical structure of Praomys misonnei (Rodentia: Muridae) in west-Central Africa based on 113 individuals from 31 localities and the sequencing of two mitochondrial genes (Cytb and CO1). Two clades can be identified through maximum likelihood, bayesian and network analyses: the first one is limited to the Korup National Park, while the second one has a broad geographical distribution in west-Central Africa. The second clade can be further divided into three sub-clades. The results of neutrality tests and mismatch distributions indicate that a population expansion occurred in these sub-clades. During the middle or upper Pleistocene, the west-Central African populations of P. misonnei may have been isolated in four different forest refugia, followed by population expansion and secondary contact during more humid periods. High genetic diversity was observed in the region of the Bakossi highlands, and the Cameroon Volcanic Line limits the geographical distribution of clades. Thus it seems likely that this volcanic line has in the past constituted a barrier that prevented the east–west exchange between P. misonnei populations through the expansion of the montane forest habitat. Our results also highlight the role of the Sanaga and Ogooué-Ivindo rivers in shaping P. misonnei genetic structure.
Assessment of immunomodulator biomarkers (Tnf-α, Il-1β and Il-6) in liver of Capoeta umbla for biomonitoring of pollution in Uzuncayir Dam Lake (Tunceli, Turkey)

This study was aimed to monitor water pullution of Uzuncayir Dam Lake using the changes of IL-6, IL1β and TNF-α levels in Capoeta umbla (Heckel, 1843) liver tissue at ten stations in March and September 2011. In this study C. umbla (Heckel, 1843) was used as the indicator organism. Tumor necrosis factor-α (TNF-α), interlekuin1β (IL-1β) and interleukin-6 (IL-6) levels were determined in samples of the liver tissue by ELISA kit. The lowest mean IL-1β levels were found at station 6. The mean IL-1β was reached its maximum level at station 2. The difference between the mean levels of IL-6 was found to be significant (p<0.05) amoung stations. The IL-6 levels were significantly increased in September at stations 1, 2, 7 and 8 (p<0.01) compared to the values in March. The mean levels of TNF-α were found to be significant (p<0.05) amoung stations. The TNF-α levels significantly decreased in September at stations 1 and 9 (p<0.01). TNF-α, IL-1β and IL-6 levels in C. umbla can be used as early diagnostic indicators against adverse environmental events and useful and reliable bioindicators in determining the pollution of the aquatic ecosystem.
Behaviour of Hens Fed a Glycanase Enzyme in a Wheat and Triticale Diet

Caged laying hens (26-38 weeks-of-age) were fed a wheat and triticale diet with and without a commercia l glycanase enzyme. Various pecking and behavioural activities of hens were monitored at 28 and 36 weeks, including the measurement of excreta pH, dry matter and moisture content. There was little influence of enzyme supplementation on he n behaviour, although there was a significant reduction (P<0.05) of trampling and increase (P<0.05) in stereotype head flicking observed in hens fed enzymes. A stepwise procedure indicated 38% of the variation associated with excreta pH was explained by excreta dry matter, excreta moisture, light intensity, receiving tail and body pecks. Receiving body pecks, giving vent pecks, excreta moisture, trampling, excreta pH, receiving tail pecks and head flicks were the variables most closely associated with light intensity. This study only identified a few changes in hen behaviour from feeding enzymes. More comprehensive investigations are required.
Kinins and Endothelial Control of Vascular Smooth Muscle

ved hyperpolarizing factor. nitric oxide. prostaglandins. angiotensin-conv erting enzyme ABSTRACT Plasma and vascular kinins stimulate the production of endothelium-deri ved nitric oxide, prostacyclin and hyperpolarizing factor (which regulates the func­ tion of vascular smooth muscle), and endothelial interactions with blood cells. The role of kinins in vasomotion is detennined by the rate of production of the peptides by kininogenases and their degradation by kininases, in particular angiotensin-conv
Biodemas de cepas do Trypanosoma cruzi isoladas de humanos de três áreas endêmicas de Minas Gerais

In order to study the biological behavior of T. cruzi strains and to determine a putative association between their biodeme and the clinical forms of Chagas disease, 14 strains isolated from humans were evaluated. The individuals were from the municipalities of Pains, Iguatama and Berilo (Minas Gerais State). The biological behavior was evaluated in albino swiss mice, weighing 10 to 15 grams, which were infected with 1x104 blood tripomastigotes. The infectivity, parasitemia, tripomastigote morphology, virulence and the tissue distribution of the protozoan were analyzed. A behavior similar to biodeme II (Sao Felipe strain) was observed in 9 strains, while 5 stocks were characterized as belonging to biodeme III. It was not possible to establish a relationship between the biodeme strain and the severity of the disease in the patients.
Identification of the most prevalent and spatially disperse virus on chilli at Northern and Eastern part of Bangladesh

The study was undertaken with a view to determining the reduction of growth and yield contributing characters due to inculpative effect of viruses in chilli (Capsicum annum L.). The results of symptomatological study among nine locations from two districts namely Sylhet and Rangpur in Bangladesh revealed that the incriminating disease incidence was 11.74% to 55.90% depending on the location. The highest prevalence (55.90%) was in Biswanath and the lowest (11.74%) was in Mithapukur. The highest plant height reduction was in Rangpur Sadar (18.27%), lowest at Kanaighat (14.14%). The highest fruit number reduction was in Mithapukur (72.49%), The highest fruit weight reduction was in Biswanath (40.64%). The lowest Fruit number and fruit weight reduction were respectively 21.18% and 22.41% at Pirgong. In order to formulate management practices for the control of virus diseases of chilli, reliable tests are required for its detection. DAC-ELISA was found as the suitable tests for the detection of viruses. In this experiment three antisera i.e. Cucumber mosaic virus (CMV), Potato virus Y (PVY), Chilli veinal mottle virus (ChVMV) were used to detect the virus separately. However, only CMV antisera gave the positive result against the virus. The results suggested that CMV as causal organism of that diseases.
On the Theory of Membrane Fusion. The Stalk Mechanism

Based on literary data, conditions necessary for membrane fusion are discussed. It is proposed that fusion mechanisms should be classified according to the primary act involving a change in the membrane structure. Two principal fusion mechanisms are identified: the stalk mechanism, starting with the appearance of a stalk between approaching membranes, and the adhesion mechanism which involves bilayer reorganization as a result of a tight junction of the membranes. The origin and evolution of the monolayer and bilayer stalks between membranes are analysed. Using the expression for the elastic energy of the stalk it was possible to find the value of the spontaneous curvature of its membrane, K,, at which the existence of a stalk is in principle possible. It is shown that, within the framework of the stalk mechanism, there exists a possibility of either the formation of a stalk of a finite radius, or complete fusion. The Xs values have been determined at which one of the variants occur. The energy barrier of the hydrophobic interaction and the elastic energy barrier, which have to be overcome by the membranes to form the stalk are analysed. The theoretical analysis of the stalk formation mechanism is supported by experimental data. It has been shown by freeze-fractu re electrone microscopy that the addition of Ca +2, Mg+2, Mn+2 or Cd +2 to suspensions of egg phosphatidylcholine and cardiolipin (1:1 or 3:1) leads to the formation of numerous intramembrane particles (imp's) and crater-like (stalk) structures.
EFFECTS OF ARGININE ON CYTOKINES AND NITRIC OXIDE SYNTHESIS IN BROILERS

The effect of dietary supplement of arginine on immunoglobulin, cytokine and nitric oxide (NO) synthesis in broilers was investigated. Three hundred one-day-old Arbor Acre mixed-sex broiler chickens were randomly allotted to five dietary treatments with six replicates in each treatment and ten chickens within each replicate. The five treatments viz., the basal diet with 0 (arginine-deficient group), 4.5 (arginine-normal group, control), 9.0, 13.5,and 18.0 g/kg arginine. The feeding experiment period was 42 days. The results of in vivo experiments showed that with increasing levels of dietary arginine, interleukin (IL)-2, NO content and inducible nitric oxide synthase (iNOS) activity in serum as well as iNOS mRNA expression in the ileum and liver of broiler chickens increasedquadratically at the age of 21 d(P<0.05). In addition, positive effects of arginine tended to be suppressed when addition of arginine in the diet was increased to 18.0 g/kg. The results of in vitro experiment indicated that, IL-2 and iNOS content increased quadratically with increasing addition of arginine (P<0.01), and 80 μg/mL arginine supplement group had the highest value. Dietary arginine improved the levels of IL-2, NO and iNOS expression in a quadratic dose-dependent manner.
Review: Water stress in sheep raised under arid conditions

Chedid, M. , Jaber, L. S. , Giger-Reverdin, S. , Duvaux-Ponter, C. and Hamadeh, S. K. 2014. Review: Water stress in sheep raised under arid conditions. Can. J. Anim. Sci. 94: 243–257. Sheep breeds which are indigenous to arid and semi-arid regions are known for their ability to adapt to rustic environments, to climatic variations as well as to shortages in resources. Water scarcity, often combined with heat stress, is a common challenge facing these animals, causing physiological perturbations and affecting the animal's productivity. This review reports the effect of different forms of water stress on physiological indicators, blood parameters, thermoregulation and immunological status in sheep. Although the breed effect may be significant, the following are generally observed common responses: drop in feed intake and weight loss, increase in evaporative cooling through panting, production of a small volume of highly concentrated urine, haemoconcentration, high blood osmolality, and immunosuppression. Prolon.
Alcohol and Female Puberty

Alcohol consumption during early adolescence may suppress the secretion of specific female reproductive hormones, thereby delaying puberty and adversely affecting the maturation of the reproductive system. These effects occur through several mechanisms, including altered production and secretion by the ovaries of estradiol, a key steroid hormone involved in the timing and regulation of female reproductive events. Alcohol can affect estradiol production by interfering with the normal function of regulatory hormones produced by the brain and the pituitary gland. Recent research has demonstrated additional potential mechanisms for alcohol’s effects on female reproductive capability, including interference with specific regulatory systems located entirely within the ovary. Such “intraovarian” systems include the insulin-like growth factor-1 (IGF-1) and nitric oxide (NO) systems. Alcohol can dampen the stimulatory effects of the ovarian IGF-1 system and can increase the inhibitory effects of the ovarian NO system. These effects combine to decrease estradiol secretion. Thus, alcohol impairs ovarian function not only by interfering with hormonal communication between the brain, pituitary gland, and ovaries but also by directly altering the function of regulatory systems within the ovaries themselves. These results provide further evidence of the risks of underage drinking and the importance of its prevention.
Role of capillary endothelium in the clearance of chylomicrons. A model for lipid transport from blood by lateral diffusion in cell membranes.

TRIGLYCERIDE, phospholipid, and cholesterol absorbed from the intestines are transported in the blood stream in the form of chylomicrons and very low density lipoproteins (VLDL). " There is considerable evidence that triglyceride of chylomicrons and VLDL is hydrolyzed during uptake from blood and that this process is catalyzed by lipoprotein l ipase. * Lipoprotein lipase activity is found in tissues that utilize triglyceride, and the level of activity in individual tissues (adipose tissue, heart, muscle, and mammary gland) varies with nutritional and physiological states that affect triglyceride uptake, such as fasting,*"" diabetes," pregnancy,'» and lactation. *" Lipoprotein lipase activity is released readily to the blood stream by heparin injection, suggesting that the enzyme is present in or near the vascular bed. '• "• lf Studies in several laboratories have shown that chylomicron triglyceride is not utilized directly by liver. "" Instead, the triglyceride is hydrolyzed to free fatty acid (FFA) by lipoprotein lipase in peripheral tissues, and some of the FFA formed is released to the blood to be taken up by liver. "" Although cholesteryl ester in chylomicrons is taken up primarily by liver,*'" this process occurs only after most of the triglyceride in chylomicrons has been removed by the action of lipoprotein lipase in peripheral tissues. " The fate of phospholipids and unesterified cholesterol in chylomicrons has not been determined. It is possible that lecithimcholesterol acyltransferase activity (LCAT) in
A Survey of Password Schemes in Different Contexts

We conduct user surveys to investigate user preferences on password schemes for mobile devices. By preforming face-to-face interviews with several individuals and testing several hypotheses, we were able to provide insight on end users and their views on where password schemes should be used. The investigation also indicates that users value access speed and minimal gestures over security and memorability. Through the surveys, we also find out users are not caring about shoulder-surfing attacks although the shoulder-surfing resistance is one of the major research topics on security. The surveys also show strong interest from users to protect individual applications with password schemes.
The Effects of Egg Weight and Storage Time on Egg Weight Loss and Hatchability Traits in Japanese Quail

This study examined the effects of egg weight and storage time on egg weight loss and hatchability traits. Egg were stored for 1, 3, 5. 7. 9 and 11 days, and collected into 3 egg weight groups (light, medium and heavier). Storage room temperature was 18-20°C and relative humidity was 55-58%. Eggs were weighted individually at laying, before placing into hatching, on days 5, 10, 14 and 18 of the hatching period to determine egg weight loss. Fertility and hatchability values decreased with the storage time. Higher fertility and less hatching were observed in heavier egg weight group. There was no significant differences between egg weight groups in terms of egg weight loss, while egg weight loss was higher in especially 9 and 11 days storage time groups (P
Modelling Hospital Surge with Data-Driven Discrete Event Simulation

Many Canadian hospitals run at or near capacity, frequently experiencing congestion due to surges in demand. “Surge Protocols” that formally define when and what kind of operational steps can be taken to alleviate congestion are routinely in use. Decisions across the hospital, regarding bed capacity and allocation, staffing levels, and the surgical block schedule influence the frequency and severity of congestion, which in turn manifests in high bed occupancy, delayed admissions, a crowded Emergency Department, surgical cancellations and increased use of surge protocols. A generic, data-driven, discrete event simulation is presented that helps hospitals assess the impact of hospital wide decisions and surge policies on each area of the hospital. The model was developed in cooperation with two hospitals, and then applied at two additional hospitals.
Impact of Modified Clays on the Infant Oyster ( Crassostrea gigas )

In this study infant oyster ( Crassostrea gigas, ～0.2cm ) was examined as experiment object to investigate the potential environmental influences on the benthic organism of HDTMA organic modified clays and PAC inorganic modified clay. The 96 h acute tests revealed the LC50 of organic and inorganic modified clay are 4.62 g/L and 2.67 g/L separately. In the concentration of 0.1 g/L, which has a high efficiency to remove harmful algae cells , the chronic test showed modified clays have no obvious toxicity on C. gigas survival percentages, and growth rates in modified clays were almost the same as those of control in the chronic test. Filtering rates increased 3～4 times than at the beginning of the culture. Both clays were never found to have negative effects on the gill and digestive gland super microstructure of infant C. gigas yet. During the clay flocculation used for algae bloom control, such as the Heterosigma akashiwo and Prorocentrum donghaiense, C. gigas survial suggested clay flocculation methods would increase infant C. gigas survival rate apparently due to the control algae plankton livability, growth and production. Therefore, HDTMA organic modified clays and PAC inorganic modified clay flocculation have prospective future as an emergent measure in controlling harmful algal blooms as emergency methods.
A Process for Evaluating Parametric Models for Mechanical Systems Simulation : the Case of a Sailboat

Emilien Lavigne, MerConcept, emilienlavigne@merconcept.com Benoît Piquemal, MerConcept, benoitpiquemal@merconcept.com Adeline Bourdon Université de Lyon, CNRS INSA-Lyon, LaMCoS UMR 5259 F-69621 Villeurbanne France, adeline.bourdon@insa-lyon.fr Simon Chesne, Université de Lyon, CNRS INSA-Lyon, LaMCoS UMR 5259 F-69621 Villeurbanne France, simon.chesne@insa-lyon.fr Goulven Guillou, Lab-STICC/UBO, goulven.guillou@univ-brest.fr Jean-Philippe Babau, Lab-STICC/UBO, babau@univ-brest.fr