Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemoradiation with FOLFOX plus cetuximab in locally advanced cardia or esophageal cancer: Final results of a GERCOR phase II trial (ERaFOX).

8 Background: Chemoradiotherapy (CRT) for locally advanced cardia and esophageal cancer is based on 5-FU combined with cisplatin, which could be favorably replaced by oxaliplatin (Ox). Cetuximab (C) has demonstrated synergism with both radiotherapy (RT) and platinum-based chemotherapy. ERaFOX trial was evaluating the safety and efficacy of the addition of C to CRT with FOLFOX. METHODS Main inclusion criteria were: stage III squamous cell or adenocarcinoma of the esophagus or gastroesophageal junction; WHO PS 0-1; age 18-80 years; weight loss <15% in the last 6 months. Patients (pts) received 2 cycles of FOLFOX induction therapy (Ox 85 mg/m2/d1, folinic acid 400 mg/m2/d1, 5-FU 2,400 mg/m2/d1-2, q2w) plus C (first infusion 400 mg/m2 then 250 mg/m2, q1w), then RT 50.4 Gy (1.8Gy/d x 28 fractions) with FOLFOX plus C (same doses, except 5-FU 1,800mg/m2/d1-2). Tumor evaluation was performed at the end of CRT (RECIST and endoscopic ultrasonography). The primary endpoint was overall response rate (ORR), with a 50% threshold for efficacy (Simon Minimax two-stage design). RESULTS From Nov 2007 to Feb 2010, 80 pts were enrolled in 12 centers. The characteristics of the 79 eligible pts were (1 ineligible pt for stage IV disease): male/female 60/19, median age 63 (23-79), PS 0/1/ND 47/31/1, squamous/adenocarcinoma/undifferentiated 53/25/1; esophagus/cardia 74/5; median daily caloric intake 1,720 Kcal (550-3160). 74 pts were treated by CRT (5 pts experienced anaphylaxis during the first cetuximab infusion). ORR (ITT) was achieved in 61 pts (77.2%), 6 pts (7.6%) had stable disease, and 9 pts (11.4%) had disease progression (3 pts were not evaluable). Grade 3-4 toxicities induction therapy/CRT were (%): neutropenia: 7.6/28.4; febrile neutropenia: 0.0/2.7; vomiting: 1.3/4.0; mucositis: 1.3/5.4; diarrhea: 3.8/2.7; dysphagia-esophagitis: 1.3/13.5; rash: 7.6/10.8; allergy 8.9/0.0. One toxic death (1.3%) occurred after CRT related to esophagitis with GI bleeding. CONCLUSIONS Threshold for efficacy was reached with an ORR of 77.2%. Chemoradiotherapy with FOLFOX plus cetuximab is active and has an acceptable toxicity profile in patients with locally advanced cardia or esophageal cancer. No significant financial relationships to disclose.
Plesiomonas Shigelloides And Sucrose‐Positive Edwardsiella Tarda Bacteremia In A Man With Obstructive Jaundice

INTRODUCTION Plesiomonas shigelloides and Edwardsietla tarda are organisms not commonly isolated from human extraintestinal sources. Most human isolates of both species are from feces specimens of patients with gastroenteritis, particularly after a history of ingesting seafood. 13 A patient admitted with obstructive jaundice secondary to a benign common bile duct stricture grew Plesiomonas shigelloides from 4 blood culture bottles and an Edwardsiella species from a further 2 blood culture bottles. The source of these organisms was not ascertained biliary fluid was unable to be collected at endoscopic retrograde cholangiopancreatography, while fecal specimens failed to isolate either organism found in the blood cultures. Isolated reports in the literature have described cases where either P. shigelloides or E. tarda were isolated from biliary fluid 4'5 this would also seem the most likely source of infection for the patient described above, given that he had no history of gastroenteritis nor of ingesting seafood prior to his presentation.
Tissue expression of the Schistosoma mansoni 28 kDa glutathione S-transferase

The expression of the Schistosoma mansoni 28 kDa glutathione S-transferase (Sm28) was studied using molecular (PCR, in situ hybridization), and immunocytochemical techniques. The presence of Sm28 was demonstrated in all developmental stages of the parasite except the intra-uterine immature egg. In the parenchyma of male and female adult worms the distribution of Sm28 was limited to a subpopulation of parenchymal cells and to the dorsal tubercles of the male. The tegument, the muscles, the digestive tract, the neural mass, the vitelline glands, and mature gametes were not immunoreactive. Immature germinal cells in both sexes, and the ootype in the female genital system, were found to express Sm28. Deposits of immunoreactive material on host skin following cercarial penetration, exfoliation from the male tubercles, and especially emission of Sm28 from eggs in hepatic granulomas are suspected to be a source of antigen during the parasite infection. The reduction in worm fecundity previously observed in immunization experiments may result from an antibody response directed against Sm28 present in the ootype. There was no cross-reactivity observed, under the experimental conditions used, between the anti-Sm28 sera and either vertebrate or invertebrate host tissue.
Osteoporose (OP) - prevenção e tratamento, uma visão atual

A osteoporose e suas conseqüências têm despertado, por ser considerada um problema moderno de saúde pública, a atenção dos governos, especialmente dos países desenvolvidos e, mais recentemente, daqueles considerados em desenvolvimento ou semiindustrializados. Com o apoio da mídia nacional e internacional, a divulgação dos conhecimentos e informações nessa área da patologia médica tem propiciado a milhões de seres humanos em todo o mundo, refletir sobre as nefastas conseqüências dessa síndrome que hoje sabemos, começa a ser desenvolvida na infância e na puberdade, quando o patrimônio ósseo está sendo estabelecido, por meio da indução genética. Portanto, as gerações que ainda não completaram a formação de suas reservas ósseas têm, desde já, adequadamente orientadas, a possibilidade de um futuro mais tranqüilo com relação à expectativa do desenvolvimento da osteoporose e de suas graves fraturas, baseadas numa estrutura profilática devidamente planificada. Esse raciocínio, é claro, pode ser aplicado, principalmente, nos países mais desenvolvidos, onde grande parte da população não só tem acesso aos serviços médicos, como também é mais bem cuidada, nutrida e esclarecida. Desse modo, acreditamos que assim deve ser iniciada a prevenção coletiva da osteoporose. Sabemos que é durante a infância e a adolescência que a massa óssea de um indivíduo é formada. Então, aqueles indivíduos que receberem uma dieta rica em cálcio e um programa adequado e constante de exercícios físicos, capitalizarão seu patrimônio ósseo futuro. Na realidade, musculaturas bem desenvolvidas, por sua vez, através do efeito piezoelétrico induzirão a construção de ossos mais sólidos. Podemos dizer que essa dieta começa na fase de lactação, em que crianças amamentadas desenvolvem mais massa óssea que aquelas não amamentadas. A base da dieta alimentar na merenda escolar deve conter entre 1000 e 1200 mg de cálcio por dia, estimulando hábitos alimentares diversos e adequados. Quanto ao estímulo à atividade física, as
Is CT During Arterial Portography Useful for the Preoperative Evaluation of Liver Metastases from Pancreatic Carcinoma?

We evaluated computed tomography during arterial portography (CTAP) for the preoperative evaluation of liver metastases from pancreatic carcinoma. Thirty-one patients with invasive ductal carcinoma of the pancreas underwent CTAP for evaluation of liver metastasis. Diagnostic accuracy of CTAP was compared with that of intravenous contrast-enhanced CT (IVCT). In this series, both CTAP and IVCT showed the same diagnostic accuracy for the patients. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of both CT examinations for detecting liver metastases were 60% (three of five), 100% (26 of 26), 100% (three of three), 93% (26 of 28), and 94% (29 of 31), respectively. CTAP did not confer any advantage over IVCT for the preoperative evaluation of liver metastases from pancreatic carcinoma.
Relevance of the Quality of Partner Relationships and Maternal Health to Early Child Wellness

Objective: To examine the relationship between child health and maternal relationship quality with a spouse/partner, self-rated health, depressive symptoms, and social support. Methods: In a cross-sectional study, structured interviews were completed with 595 mothers in 2002. Women were recruited from a random sample of households in low-income communities of Teresina, Piauí. Child health status was assessed with the Eisen Infant Health Rating Scale and a composite index of child fever, worms, or diarrhea in the past 2 weeks. Exposure variables included maternal relationship quality, self-rated health, depressive symptoms, and social support. Analyses included multivariable linear and logistic regression modeling, controlling for sociodemographics. Results: Both a high-quality partner relationship and good/excellent maternal self-rated health were significantly associated with higher scores on the Eisen Infant Health Rating Scale (â = 0.9; 95% confidence interval [CI]: 0.3–1.4 and &bgr; = 1.1; 95% CI: 0.7–1.6, respectively). Every 5-point increase in depressive symptoms was negatively associated with infant health scores (&bgr; = −0.3; 95% CI: −0.4 to −0.1) and with recent child wellness (lack of fever, diarrhea, or worms) (odds ratio = 0.9 95%; CI: 0.8–1.0). Conclusion: Maternal factors, such as partner relationship quality and health status, may be important to child health and should be considered for inclusion in confirmatory longitudinal studies.
Eziopitant. Pfizer.

Pfizer is developing ezlopitant, a neurokinin-1 antagonist, for the potential treatment of irritable bowel syndrome (IBS). The compound had undergone phase II trials in the US and Europe, and phase I in Japan for treatment of chemotherapy-induced emesis [290988], [320737], [329187]. A phase II, double-blind, randomized study was performed to assess the safety and efficacy of ezlopitant for the control of cisplatin-induced emesis. Treatment was well tolerated [290988]. Although the compound effectively controls emesis, it is less effective in controlling nausea, and development has been discontinued for the emesis indication [347367]. Ezlopitant has undergone a pilot study in 14 IBS patients [367631].
Chronological development of elevated aminotransferases in a nonalcoholic population

The incidence and risk factors of nonalcoholic fatty liver disease (NAFLD) have never been prospectively determined. To determine the frequency and risk factors of NAFLD and chronological ordering between NAFLD, weight gain, and features of insulin resistance, a historical cohort study was conducted in a Japanese workplace. A cohort free of previous liver injury, alcohol consumption of more than 140 g/wk, and hepatitis B or C infection (529 of 1,537 subjects), and a subcohort of 287 subjects free of insulin resistance–related features were identified. Elevated aminotransferases in nonalcoholics were used as a surrogate for NAFLD. High aminotransferases together with weight gain of more than 2 kg and insulin resistance–related features in the subcohort were sought for up to 5 years. The incidence of high aminotransferases was 31 per 1,000 person‐years (71 events). A significant interaction occurred between age and sex in the development of high aminotransferases. In subjects younger than age 40 years, male sex (hazard ratio [HR]: 4.6), elevated body mass index (HR: 2.1), hypertension (HR: 2.6), and low high‐density lipoprotein cholesterol (HR: 2.8) increased the risk of high aminotransferases, whereas age (HR: 0.6 for each 5 years) decreased the risk. In subjects older than age 40 years, glucose intolerance (HR: 5.3) was the only significant risk factor. In the subcohort, weight gain preceded high aminotransferases and other insulin resistance–related features, which appeared sequentially in order of low high‐density lipoprotein cholesterol, hypertriglyceridemia/hypertransaminasemia/hypertension, and glucose intolerance. In conclusion, this cohort study clearly showed chronological ordering and an association between development of elevated aminotransferases and risk factors of NAFLD. (HEPATOLOGY 2005;41:64–71.)
SIW compact diplexer

A compact diplexer fabricated on substrate-integrated waveguide (SIW) technology is presented. The diplexer is a coupled-resonator network with no additional elements such as power dividers, composed exclusively of six SIW resonators coupled through inductive irises, with one transmission zero at each channel that improves the selectivity. The close physical proximity of the resonators and the leakage associated to via-hole walls characteristic of the SIW technology are the main challenge of this design. However, this effect can be taken into account, as proved by a fabricated prototype with pass bands around 8 GHz.
Pulmonary granulocyte margination is increased in patients with inflammatory bowel disease.

The pulmonary granulocyte content of the lung was quantified in patients with inflammatory bowel disease (IBD) after injection of 111In-labelled granulocytes and compared with patient controls, who, on the basis of their negative white cell scans, were not considered to have active inflammation. The mean ratios of lung:liver count rates per pixel on the posterior gamma camera image in patient controls was 0.34 (S.D. 0.16, n = 8) at 1-1.5 h after injection of the cells, and 0.29 (S.D. 0.14, n = 18) at 2-4 h. This ratio was higher in patients with active IBD at both imaging times: 0.45 (0.13, n = 13, P > 0.05) and 0.44 (0.1, n = 19, P < 0.001). Patients with inactive IBD also had increased ratios at both imaging times: 0.6 (0.14, n = 7, P < 0.01) and 0.54 (0.15, n = 12, P < 0.001), respectively. In a further group of 12 patients with active IBD, there was no correlation between the lung:liver ratio and the severity of the IBD as assessed by whole-body 111In retention at 4-6 days after labelled cell injection. These patients were treated for 3 weeks with an oral, non-absorbable corticosteroid, after which there was a significant decrease in disease activity but no significant change in the lung:liver ratio. Inflammatory bowel disease appears to be associated with abnormal pulmonary granulocyte accumulation. It is not apparently related to disease activity but may be the result of an associated pulmonary abnormality.
Energy efficient reconfigurable antenna for ultra-low power IoT devices

This paper presents a very low consuming re-configurable antenna suitable for ultra-low power internet-of-things (IoT) devices. Thanks to the use of a Digital Tunable Capacitor (DTC), the antenna can be reconfigured to obtain good impedance matching and optimized efficiency for different configurations of the close environment.
STATIN TREATMENT WITHDRAWAL IN ISCHEMIC STROKE: A CONTROLLED RANDOMIZED STUDY

procedures. The document went through seven cycles of review over the course of 2 years. Approximately 140 individuals had the opportunity to review the document; their input was incorporated. The timing of publication was determined by this complex process. The letter states that the conflicts between the ILADS published recommendations and the AAN and IDSA Guidelines “have established two standards of care. ” However, the Summary and Disclaimer section of the ILADS document states “they were not intended to be a standard of medical care. ”3 Finally, the letter emphasizes the “obligation to acknowledge scientific uncertainty. ”We agree completely. The AAN explicitly acknowledges scientific uncertainty in its Classification of Recommendations (Appendix 3), requiring, e.g., consistent Class I studies for a Level A recommendation.1 Each recommendation is reached by systematically reviewing all relevant studies, explicitly specifying the Class of evidence of each. Insofar as the ILADS Guidelines are presented as an alternative “evidence-based guideline” it is helpful to assess them by the same standards. The processes of ILADS Guideline development and review are not explicitly stated. The evidence cited consists of 66 references. Almost half are reviews, meeting presentations, opinion pieces, studies in progress, or articles from non-Medline journals. One is a selfpublishedWeb site. Of the remainder, three address treatment response and are not cited in the IDSA or AAN Guidelines. Two of these are anecdotal case series (two and four patients); one involves treatment of erythema migrans (in Europe). No studies were explicitly assessed for quality of evidence. Table 1, summarizing Strength of Evidence, compares ILADS conclusions to the 2000 IDSA Guideline.6 For five items IDSA reached no conclusion because data were lacking; ILADS rates the data II or III for these items, without identifying additional studies. In five conditions ILADS rates the strength of the evidenceAbut data quality II or III. “A” conclusions require at least two Class I studies (AAN criterion). We agree with Stricker and Johnson that Guidelines must be based on an unbiased rigorous assessment of the available data. We believe the AAN Guideline easily meets this standard. J. Halperin, MD, C.T. Bever, MD, A.L. Belman, MD, L. Dotevall, MD, G. Gronseth, MD, L. Krupp, MD, E. Logigian, MD, E.D. Shapiro, MD, G.P. Wormser, MD, St. Paul, MN
An Animal Model for Endotracheal Tube–Related Laryngeal Injury Using Hypoxic Ventilation

Objectives. To explore whether hypoxic ventilation could allow a practical animal model of laryngotracheal injury secondary to endotracheal intubation. Study Design. Randomized controlled animal study. Setting. Animal laboratory in a tertiary pediatric hospital. Subjects and Methods. Eight Sus scrofa piglets (15-18 kg) were anesthetized and intubated for 4 hours, with a 6-mm cuffed endotracheal tube. They were randomly assigned to either constant hypoxic ventilation (oxygen saturation under 70%) or nonhypoxic ventilation. Endotracheal tube cuff pressure was manually controlled and maintained at a constant level. After 4 hours, fluorescein dye was administered intravenously to highlight areas of hypoperfusion within the larynx. The animals were euthanized at the end of the procedure, and the larynx and trachea were harvested for gross and histological examination. The pathologist was blinded to the ventilation group. The severity of laryngeal injury was graded between 0 and 4 by a senior pathologist. Results. The experiment protocol was successfully completed in all animal subjects. The animals undergoing hypoxic ventilation showed a significantly higher median injury grade than the nonhypoxic animals (2 vs 1, respectively; P = .003). Damage was significantly worse in the hypoxic group at all anatomical sublevels. Conclusions. Endotracheal tube–related laryngeal injury was demonstrated after only 4 hours of intubation using this animal model, and hypoxic ventilation increased the severity of injury. This study therefore provides an animal model that may be suitable for future investigation and prevention of intubation injury.
Accuracy and stability of hyperopic treatments

Purpose of review Treatment of hyperopia presents greater challenges than treatment of myopia for multiple reasons, including the fact that hyperopia tends to progress with age and becomes more symptomatic with the loss of accommodation. Recent findings Despite these issues, surgeons have multiple options to treat hyperopia successfully. Modern laser vision correction has high success rates for most patients and performs acceptably in the presence of high hyperopia or high cylinder. Early studies combining excimer laser treatment with collagen cross-linking (CXL) suggest that this may improve refractive stability. Recent studies have also described femtosecond lenticule extraction and use of a solid-state laser in place of the excimer. In addition to cornea-based treatment, long-term studies of a hyperopic phakic intraocular lens have shown excellent visual outcomes and good safety. Cross-linking is increasingly being applied to the hyperopia that follows radial keratotomy. Summary The established treatments for hyperopia continue to accumulate evidence supporting their safety and efficacy. The next step forward in treatment may arise from combining these treatments with CXL to stabilize the cornea long-term.
Direction-of-Arrival Channel Measurements with Real MIMO Prototype at 4.6 GHz

The carrier frequency between 4.4 GHz to 4.6 GHz is a promising spectrum for 5G mobile communications. In this paper, the MIMO channels at 4.6 GHz are measured and analyzed with massive MIMO TDD prototype. The DoA in uplink and downlink channels are investigated, with which channel reciprocity is analyzed. The measured scenarios cover LOS, NLOS, and blockage channels in outdoor microcell environment. Channel calibrations via air interface are performed in transmit antennas and receive antennas in order to estimate the spatial spectrum of the channels. DFT and MUSIC algorithms are presented for DoA estimation. Based on the channel measurements and analysis, we find that the MIMO channels are well symmetric in terms of channel impulse response profile and DoA in downlink and uplink. The channel symmetry, however, is weakened for blockage and NLOS, particularly in case of near-field blockage and full-blocked NLOS. These findings are beneficial information to the design of 5G systems.
Design of cylindrically bent antenna array on LCP substrate with large coverage at 60 GHz

The relative permittivity and homogeneity of LCP material have been characterized within the whole 60 GHz frequency band using the microstrip ring resonator (MRR) method. Using a circuit model, the gap capacitance of the MRR has been taken into account in order to improve the accuracy of the determined relative permittivity. The results show that the relative permittivity of LCP is almost constant (εr ≈ 3.1) within the whole 60 GHz frequency band. The homogeneity of LCP is within 1.5% across the LCP panel. A cylindrically bent antenna based on LCP substrate has been designed, which has 56.3–67.0 GHz bandwidth and 6 dBi gain. With the proposed equilateral triangle grid array topology and sub-array switching, the cylindrically bent antenna array with 16 antenna elements has 13.8 dBi gain up to ±60° scan angles.
Use of Gammaglobulin to Lower Elevated Natural Killer Cells in Patients with Recurrent Miscarriage.

OBJECTIVE To evaluate the effectiveness of intravenous immunoglobulin (IVIG) in patients presenting with recurrent miscarriage and abnormally elevated natural killer (NK) cells. STUDY DESIGN This retrospective patient controlled evidence level II-2 pilot study was conducted at Cohen Center, P.A. , Medical City Dallas Hospital. Ninety women with a history of recurrent miscarriage (average, 5) and elevated NK cells were retrospectively evaluated to document the outcome of their treatment with IVIG. RESULTS Of 90 women with elevated NK cells who received IVIG treatment, 78 (86.7%) became pregnant. Sixty-four (82.0%) of those pregnancies had a successful viable outcome. Fourteen (18.0%) gestations ended as first trimester miscarriages. CONCLUSION We conclude at evidence level II-2 that, with adequate precautions, low-dose IVIG therapy is safe and effective for women with immunologic abortion and documented abnormally elevated NK cells.