Miracle-dz/UniFAR-FTUs huggingface dataset:
Panic Disorders: Current Perspectives

The overview article that follows reports the major ideas and data presented by the speakers and the symposium moderator, Richard I. Shader, MD, Professor and Chairman of the Department of Psychiatry of the Tufts University School of Medicine and Psychiatrist-in-Chief at the New England Medical Center. Donald F. Klein, MD, Director of Research at the New York State Psychiatric Institute and Professor of Psychiatry at the Columbia University College of Physicians and Surgeons, gave an overview of the concepts and diagnosis of panic disorders. Lactate challenge testing, as it is currently being studied at the New York State Psychiatric Institute, was described by Michael R. Liebowitz, MD, Assistant Professor of Clinical Psychiatry at the Columbia University College of Physicians and Surgeons and Director of the Anxiety Disorders Clinic at the New York State Psychiatric Institute. Raymond R. Crowe, MD, Professor of Psychiatry at the University of Iowa, outlined his and Dr. Russell Noyes' findings about the genetic aspects of panic disorders. David V. Sheehan, MD, Assistant Professor of Psychiatry at Harvard Medical School and Director of the Hypnosis and Psychosomatic Medical Unit of the Massachusetts General Hospital, summarized the success and failure of various regimens used in their research protocols to treat panic disorders and also presented a tentative classification system for these disorders. He was followed by Bernard J. Carroll, MD, PhD, who compared the findings of the dexamethasone suppression test in anxious and depressed patients. Dr. Carroll is Professor of Psychiatry and Acting Chairman of the Department of Psychiatry at the University of Michigan. F. Andrew Gaffney, MD, Assistant Professor of Medicine and Cardiology at the University of Texas Health Science Center (Dallas), described the mitral valve prolapse syndrome and its relationship to panic disorders. The pharmacokinetics of psychotropic drugs were reviewed briefly by David J. Greenblatt, MD, Professor of Psychiatry and Associate Professor of Medicine at the Tufts University School of Medicine and Chief of the Division of Clinical Pharmacology in the Departments of Psychiatry and Medicine at the New England Medical Center.
THE INFLUENCE OF DEUTERATION AND TURBULENT DIFFUSION ON THE OBSERVED D/H RATIO

The influence of turbulent mixing on the chemistry of the interstellar medium (ISM) has so far received little attention. Previous studies of this effect have suggested that it might play an important role in mixing the various phases of the ISM. In this paper, we examine the potential effects of turbulent diffusion on the deuterium chemistry within molecular clouds. We find that such mixing acts to reduce the efficiency of deuteration in these clouds by increasing the ionization fraction and reducing freeze-out of heavy molecules. This leads to lower abundances for many deuterated species. We also examine the influence of turbulent mixing on the transition from atomic hydrogen to H2 and from atomic deuterium to HD near the cloud edge. We find that including turbulent diffusion in our models serves to push these transitions deeper into the cloud and helps maintain a higher atomic fraction throughout the cloud envelope. Based on these findings, we propose a new process to account for the significant scatter in the observed atomic D/H ratio for galactic sightlines extending beyond the Local Bubble. Although several mechanisms have been put forward to explain this scatter, they are unable to fully account for the range in D/H values. We suggest a scenario in which turbulent mixing of atomic and molecular gas at the edges of molecular clouds causes the observed atomic D/H ratio to vary by a factor of ∼2.
Olfactory transduction in ciliated receptor neurons of the Cabinza grunt, Isacia conceptionis (teleostei: haemulidae)

The ciliated receptor neurons of fish olfactory organs are thought to transduce amino acids through a cAMP‐dependent transduction pathway, but direct physiological evidence for this hypothesis remains scarce and is confined to catfish and trout. We investigated olfactory transduction in a marine fish, the Cabinza grunt Isacia conceptionis (Perciformes, Teleostei). The olfactory epithelium was characterized using light and electron microscopy, and isolated ciliated receptor neurons were recorded with the perforated patch‐clamp technique. Cells were stimulated with puffer pipettes containing amino acid odourants, IBMX plus forskolin or 8bromo‐cAMP. All three stimuli triggered transient inward currents at a holding potential of −70 mV and responses with outward‐rectifying current–voltage relationships. The characteristics of the transduction currents induced by each stimulus were similar across cells and indistinguishable within the same cell, supporting the hypothesis of a cAMP pathway mediating transduction of amino acids in ciliated olfactory receptor neurons.
Expresión de proteínas heterólogas en plantas por medio del virus de la Sharka

En esta tesis se estudian los vectores de expresion basados en el virus de la sharka (PPV), compaando su comportamiento en diferentes huespedes herbaceos a nivel de sintomatologia, acumulacion viral, expresion de la proteina heterologa y estabilidad de la secuencia insertada. Se estudia la estabilidad de los vectores virales basados en PPV insertando diferentes secuencias heterologas y analizando los diferentes comportamientos observados. Por otro lado, en esta Tesis se han modificado los vectores virales existentes a nivel de secuencia y a nivel de expresion: obteniendo expresion constitutiva mediante plantas trangenicas que incorporan genoma parcial o completo de PPV. Es el primer caso descrito con plantas transgenicas que poseen como trangen el genoma completo de PPV y de PPV insorporando la secuencia de la proteina de la fluorescencia verde. Por ultimo se ha conseguido desarrollar por primera vez una doble quimera en la que se expresan dos proteinas heterologas de forma simultanea e independiente expresadas en el mismo foco celular mediante PPV.
Card Games and Algebra Tic Tacmatics on Achievement of Junior Secondary II Students in Algebraic Expressions

This study investigated the Card Games and Algebra tic-Tacmatics on Junior Secondary II Students’ Achievement in Algebraic Expressions. Three research questions and three null hypotheses guided the study. The study adopted the pre-test, post-test control group design. A total of two hundred and forty (240) Junior Secondary School II students were used as sample for this study. The experimental group was taught using games while the control group was taught using the conventional (lecture) method. Algebraic Achievement Test (AAT) was used to collect data for this study. AAT was validated by three experts in mathematics education and measurement and evaluation respectively. The reliability index of AAT was 0.79. Mean and standard deviation were used to answer the research questions while ANCOVA was used to test the hypotheses at 0.05 level of significance. The findings of the study showed among others that there was a significant difference between students taught algebraic expressions with games and those taught without games, there was also a significant difference between the achievement of males and females taught algebraic expressions with games and those taught without games in favour of the males.
Experimental validation of the moving long base-line navigation concept

This paper presents the moving long base-line (MLBL) navigation concept as well as simulation and experimental results. This multiple vehicle navigation technique consists of using vehicles fitted with accurate navigation systems as moving reference transponders to which other vehicles, fitted with less capable navigation systems, can acoustically range to update their position. Reliable acoustic communications are mandatory for the real time implementation of this navigation scheme. However, while enabling MLBL, acoustic communications reduce the range update rate and introduce delays that need to be dealt with in the navigation algorithm. Simulation results show that relative navigation accuracy between vehicles can be maintained although the absolute navigation accuracy of each vehicle decreases over time. This is a key enabling factor for AOFNC missions where contacts are called by vehicles and re-acquired by other vehicles in real-time.
Reducing the Number of Solutions of NP Functions

We study whether one can prune solutions from NP functions. Though it is known that, unless surprising complexity class collapses occur, one cannot reduce the number of accepting paths of NP machines [17], we nonetheless show that it often is possible to reduce the number of solutions of NP functions. For finite cardinality types, we give a sufficient condition for such solution reduction. We also give absolute and conditional necessary conditions for solution reduction, and in particular we show that in many cases solution reduction is impossible unless the polynomial hierarchy collapses.
Avaliação de abordagens alternativas de previsão no estudo de séries de vazões

O presente trabalho discute a influencia do uso de diferentes formas de previsao construidas em estudos de series mensais de vazoes fluviais. Uma das maneiras usualmente adotadas pelo Setor Eletrico Brasileiro (SEB) e o uso de 12 preditores lineares mensais do tipo periodico auto-regressivo, e previsoes recursivas para horizontes mais longos que um passo a frente. Uma alternativa possivel e a utilizacao de um unico modelo para toda a serie e realizar de maneira direta para horizontes de mais de um passo a frente. Os resultados computacionais obtidos neste trabalho indicam que a forma frequentemente adotada pelo SEB pode nao ser a mais adequada para a solucao do problema. Os estudos de caso indicam tambem que a arquitetura de redes neurais artificiais do tipo maquina de aprendizado extremo alcancou melhor desempenho que os modelos lineares.
Studium przypadku jako metoda badania relacji międzyorganizacyjnych w marketingowym procesie budowania marki terytorium w oparciu o kulturę – koncepcja badań

Streszczenie: Artykuł ma na celu przybliżenie znaczenia specyfiki wykorzystania studium przypadku (case study) jako metody badawczej pozwalającej na opisanie relacji międzyorganizacyjnych w marketingowym procesie budowania marki miasta i regionu w oparciu o kulturę. Badania mają na celu identyfikację determinant wpływających na skuteczną współpracę administracji samorządowej (urząd miasta, urząd marszałkowski) z instytucjami kultury (muzea, ośrodki kultury, teatry itd.) w kontekście realizacji procesów marketingowych zorientowanych na budowanie marki terytorium w oparciu o kulturę. Projekt ma też na celu określenie motywów nawiązywania i utrzymywania relacji współpracy z perspektywy miejskich i regionalnych instytucji kultury oraz samorządowej administracji publicznej. Opracowanie ma charakter pracy koncepcyjnej.
Back Propagation Grouping: Load Balancing at Global Scale When Sources Are Skewed

Load balancing is the salient problem in data stream processing systems and also in complex event processing systems. And the imbalance in operational workers becomes extremely apparent as the scale is up with more workers and skewed datasets. In this paper, we find out that the upstream skewed sources can also exacerbate the load imbalance in the downstream workers and this bottleneck cannot be handled well by existing schemes. Thus, we propose a novel stream partitioning solution called BACK PROPAGATION GROUPING (BPG), and its core components are key splitting, back propagation and calibration signal. We verify BPG in theory and test it on both real-world and synthetic data streams. The results show that the imbalance is 10–100x less with BPG than with the previous state-of-the-art. And this metric translates into an improvement of up to 34% in throughput when deployed on Apache Storm cluster. In conclusion, BPG mitigates the load imbalance dramatically on highly skewed datasets and especially when the sources are also skewed.
A new (cartesian) reaction-path model for dynamics in polyatomic systems, with application to H-atom transfer in malonaldehyde

A new kind of reaction-path model for describing reactions in polyatomic molecular systems is presented, based on the cartesian coordinates of the atoms. Not only does this lead to a simpler treatment of the interaction between the ‘system’(i.e. the reaction coordinate) and the ‘bath’(the other degrees of freedom) than earlier reaction-path, models based on the (curvilinear) steepest-descent reaction path, but in many cases it also provides a more natural description of the dynamics. The resulting Hamiltonian has the standard form of a cartesian ‘system’ linearly coupled to a harmonic ‘bath’, the dynamics of which is treated in this paper by the basis set method of Makri and Miller (J. Chem. Phys., 1987, 86, 1451). Application to a model of H-atom transfer in malonaldehyde shows that the overall approach (both the cartesian reaction-path model and the basis-set method treatment of the dynamics) is quite successful.
Symptoms associated with gastroesophageal reflux disease: development of a questionnaire for use in clinical trials.

UNLABELLED Many persons who suffer from GERD report additional symptoms, e.g., chest pain, dyspepsia, dysphagia, that are often not measured in clinical trials even though they may be distressing to the GERD sufferer. The primary goal of this study was to develop and assess the psychometric characteristics of a new GERD symptom scale measuring frequency, severity, and distress. The GERD Symptom Assessment Scale (GSAS) was administered to a sample of 169 GERD sufferers at baseline and two weeks. Internal consistency, construct validity, and test-retest reliability were assessed. Responsiveness was evaluated using clinical trial data assessing drug efficacy. RESULTS Internal consistency was >0.80 for the symptom severity and distress scales. All three scales showed stability over two weeks (ICC >0.70). Both validity hypotheses were supported. Comparison of effect sizes showed the GSAS is sensitive to changes in severity of symptoms. In conclusion, the GSAS is a reliable, valid, and responsive measure of GERD symptoms.
Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity*

Endothelial nitric-oxide synthase (eNOS) and caveolin-1 are associated within endothelial plasmalemmal caveolae. It is not known, however, whether eNOS and caveolin-1 interact directly or indirectly or whether the interaction affects eNOS activity. To answer these questions, we have cloned the bovine caveolin-1 cDNA and have investigated the eNOS-caveolin-1 interaction in an in vitrobinding assay system using glutathione S-transferase (GST)-caveolin-1 fusion proteins and baculovirus-expressed bovine eNOS. We have also mapped the domains involved in the interaction using anin vivo yeast two-hybrid system. Results obtained using both in vitro and in vivo protein interaction assays show that both N- and C-terminal cytosolic domains of caveolin-1 interact directly with the eNOS oxygenase domain. Interaction of eNOS with GST-caveolin-1 fusion proteins significantly inhibits enzyme catalytic activity. A synthetic peptide corresponding to caveolin-1 residues 82–101 also potently and reversibly inhibits eNOS activity by interfering with the interaction of the enzyme with Ca2+/calmodulin (CaM). Regulation of eNOS in endothelial cells, therefore, may involve not only positive allosteric regulation by Ca2+/CaM, but also negative allosteric regulation by caveolin-1.
Physiological and Acoustic Correlates of Perceived Stress

In speech production, syllables that are stressed differ from those that are unstressed along at least four parameters: duration, fundamental frequency, overall intensity, and spectral composition. This paper reviews acoustic and physiological studies concerned with these features and how they might be accounted for by a single physiological mechanism. The perception of stress is then considered in the context of recent experiments that manipulated these parameters either singly or multi-dimensionally. The results of this line of experimentation suggest that the perception of stress, like its production, is related to a complex of acoustic features.
Impact of cancer on work and education among adolescent and young adult cancer survivors.

PURPOSE To examine the impact of cancer on work and education in a sample of adolescent and young adult (AYA) patients with cancer. PATIENTS AND METHODS By using the Adolescent and Young Adult Health Outcomes and Patient Experience Study (AYA HOPE)-a cohort of 463 recently diagnosed patients age 15 to 39 years with germ cell cancer, Hodgkin's lymphoma, non-Hodgkin's lymphoma, sarcoma, and acute lymphocytic leukemia from participating Surveillance, Epidemiology, and End Results (SEER) cancer registries-we evaluated factors associated with return to work/school after cancer diagnosis, a belief that cancer had a negative impact on plans for work/school, and reported problems with work/school after diagnosis by using descriptive statistics, χ(2) tests, and multivariate logistic regression. RESULTS More than 72% (282 of 388) of patients working or in school full-time before diagnosis had returned to full-time work or school 15 to 35 months postdiagnosis compared with 34% (14 of 41) of previously part-time workers/students, 7% (one of 14) of homemakers, and 25% (five of 20) of unemployed/disabled patients (P < .001). Among full-time workers/students before diagnosis, patients who were uninsured (odds ratio [OR], 0.21; 95% CI, 0.07 to 0.67; no insurance v employer-/school-sponsored insurance) or quit working directly after diagnosis (OR, 0.15; 95% CI, 0.06 to 0.37; quit v no change) were least likely to return. Very intensive cancer treatment and quitting work/school were associated with a belief that cancer negatively influenced plans for work/school. Finally, more than 50% of full-time workers/students reported problems with work/studies after diagnosis. CONCLUSION Although most AYA patients with cancer return to work after cancer, treatment intensity, not having insurance, and quitting work/school directly after diagnosis can influence work/educational outcomes. Future research should investigate underlying causes for these differences and best practices for effective transition of these cancer survivors to the workplace/school after treatment.
Comparative growth of ectomycorrhizal basidiomycetes (Hebeloma spp.) on organic and inorganic nitrogen

In the largely organic soils in which ectomycorrhizas are commonly found, a preference for absorbing organic nitrogen over mineral forms is likely to be an advantage, especially where mineralisation rates are low. To determine rates of both independent and preferential growth of ectomycorrhizal basidiomycetes on organic and inorganic nitrogen, strains of Hebeloma were grown on nutrient agar media containing either NH4+ or glutamic acid as the sole source of nitrogen, on both single medium and split plate Petri dishes. Growth rates on the split plate Petri dishes, where the fungi had access to both nitrogen sources, were generally greater than on the single medium dishes. Growth on glutamic acid was at least equal to, and usually greater than, that on NH4+. In some cases growth on NH4+ alone appeared severely inhibited, a condition that was partially alleviated by access to glutamic acid on the split plates Petri dishes. This highlights a potential pitfall of single nitrogen source growth studies. The greater growth of most strains on glutamic acid suggests an adaptation to organic nitrogen utilisation in these strains. If this is so in soils with low mineralisation rates, direct uptake of amino acids by ectomycorrhizal plants could by‐pass the bottle neck that requires mineral nitrogen to be made available for plant uptake.
Functional role of BK virus tumor antigens in transformation

We have examined the role of the human papovavirus BK virus (BKV) tumor (T) antigen(s) in the maintenance of transformation and have identified the domain of T antigen essential for transformation. BKV-transformed BHK 21 and NIH 3T3 cells expressing antisense T-antigen RNA lose their ability to grow in soft agar, indicating the need for the continued expression of T antigen for the maintenance of the transformed phenotype. Experiments using translation termination linker insertion and deletion mutagenesis of BKV T antigen demonstrate that amino acids 356 to 384 are essential for transformation. Although BKV T antigen shares 100, 95, and 82% amino acid homology with that of simian virus 40 (SV40) for the nuclear localization signal, p53-binding domain, and DNA-binding domain, respectively, the transformation domains of BKV and SV40 T antigens share only 54% homology. Also, BKV T antigen lacks a substantial portion of the ATPase domain of SV40, and our results indicate the dispensability of the remaining portion for transformation by this protein. We suggest that the differences in the amino acids in the identified transformation domains together with the differences in the ATPase domains may account for the differences in the transformation potentials of the two proteins.
Analysis of a Positional Candidate Gene for Inflammatory Bowel Disease: NRAMP2

Summary: Genome scans have identified a region spanning 40 cM on the long arm of chromosome 12 as a susceptibility locus for inflammatory bowel disease (IBD). This locus contains several candidate genes for IBD, one of which is the gene for the natural resistance associated macrophage protein 2 (NRAMP2). This protein is a divalent cation transporter and is expressed in many cells and tissues. The putative role of this protein in innate immunity prompted us to investigate a possible relationship between NRAMP2 and IBD. We assessed the frequency of four restriction fragment length polymorphisms (IVS2+11A/G, IVS4+44C/A, 1254T/C, and IVS15Exl6‐16C/G) in a group of 155 Crohn's disease (CD) patients, 114 ulcerative colitis (UC) patients, and 189 healthy controls. Linkage analysis was performed in a group of 70 families with multiple members suffering from IBD. We searched for additional intragenic markers and mutations by sequence analysis of the natural resistanceassociated macrophage 2 gene of 33 CD patients, with a positive family history for IBD. We identified one novel restriction fragment length polymorphism in intron 15 of the gene. The frequency of the rare allele is: 0.08 in our control population. An increased frequency of this allele was found in CD patients but this difference did not reach statistical significance. A weak association between CD and homozygosity for the G allele of the IVS2+11A/G was found (OR [odds ratio] = 2.2, CI [confidence interval] = 1.3‐3.9, &khgr;2 = 8.4, p = 0.013). Nonparametric linkage analysis and transmissions disequilibrium tests did not provide evidence for linkage of NRAMP2 to IBD, UC, or CD. Sequence analysis of the exons and the iron‐responsive element in a panel of 33 CD patients did not reveal any mutations in NRAMP2. Our association, linkage, and sequence analysis in IBD shows that the putative genetic risk factor on chromosome 12 likely is not NRAMP2. The weak association between the G/G genotype of IVS2+11A/G and CD may be due to linkage disequilibrium with a nearby disease‐causing gene.