Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of High-Molecular-Weight Glutenin Subunits and Their Coding Genes from Aegilops umbellulata

The high_molecular_weight (HMW) glutenin subunits and their coding genes from Aegilops umbellulata Zhuk. (UU, 2n = 2x = 14) were characterized using SDS_PAGE analysis and molecular approaches. SDS_PAGE analysis showed that the 1Ux subunits from four different accessions possessed electrophoretic mobilities close to, or slower than, that displayed by the 1Dx2.2 subunit of common wheat. The electrophoretic mobilities of the 1Uy subunits were generally similar to those shown by the 1Dy subunits of common wheat. The complete open reading frames of the 1Ux and 1Uy genes were amplified by PCR and subsequently cloned and sequenced. Amino acid sequence comparisons suggested that the primary structure of the 1Ux and 1Uy subunits were identical to that of published HMW glutenin subunits from related species. Phylogenetic analysis indicated that the HMW glutenin subunits of Ae. umbellulata were most closely related to those encoded by the D genome of Triticeae.
Radiomics and Bladder Cancer: Current Status

Giovanni E. Cacciamania,b,1, Nima Nassiria,1, Bino Varghesec, Marissa Maasa, Kevin G. Kingc, Darryl Hwangc, Andre Abreua, Inderbir Gilla and Vinay Duddalwara,b,c,1,∗ aUSC Institute of Urology and Catherine and Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA bNorris Cancer Center, University of Southern California, Los Angeles, CA, USA cDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Partial Purification, Characterization, and Application of Extracellular Aspartic Protease from Lactobacillus casei WSP in Producing the Bioactive Peptides with Antibacterial and Antioxidant Activity

Lactobacillus casei WSP-derived an aspartic protease was sequentially purified by using chromatography gel filtration sephadex G-50. It resulted in a 22.81-fold increase of specific activity (51.5 U/mg) with a final yield of 1.9%. The estimated molecular weight of the purified enzyme was 37 kDa and showed gelatinolytic activity in zymogram assay. The enzyme exhibited optimum activity at 40ºC and pH 6 with casein as the substrate. Enzyme activity was significantly inhibited by pepstatin A (0.5 mM and 1 mM), confirming that this enzyme is a group of aspartic proteases, while other inhibitors such as EDTA, PMSF and iodoacetic acid showed no inhibition effect on the activity of enzyme. The addition of metal ion to the enzyme decreased enzyme activity, indicating the proteolytic enzyme was metal ion- dependent. Denaturant such as DDT tended to increase caseinolytic activity. Furthermore, this enzyme was capable of generating the new peptides from skimmed milk with the size 8 kDa, 10 kDa and 15 kDa. These peptides have potential as antibacterial and antioxidant agents.
Comparison of the Effect of Oral versus Injectable Vitamin D on Serum Level of Vitamin D in Children with Vitamin D Deficiency Referred to the Taleghani Hospital in Gorgan

Introduction: Vitamin D deficiency in children is associated with short stature, underdevelopment, respiratory infections, and many other features that increase the risk of childhood complications. Various studies have been conducted on different and appropriate strategies for the treatment of vitamin D deficiency that there are disagreements about the use of vitamin D3 or vitamin D2, oral versus intramuscular (IM), fixed or titrated doses, low daily doses or intermittent high doses. (17) This study also attempts to answer one of these cases and designed to compare the effect of vitamin D injectable form versus oral pearl vitamin D on serum vitamin D level in children with vitamin D deficiency referred to Taleghani Gorgan Training Center. Material and Methods: In this study, one group was given 1 pearl vitamin D every week for eight weeks, and the second group was given a single dose of vitamin D 300,000 unit after 1 month and 3 months of treatment. Serum vitamin D levels were measured in all patients at Taleghani Gorgan Medical Center by one person and with one kit at all stages (baseline, 1 month, and 3 months after treatment). Results: In this study, 118 patients were enrolled in the study, 5 in the oral treatment group and 4 in the injection treatment group were excluded due to lack of follow-up, discontinuation of medication and incomplete patient records. Finally, 54 patients were in the oral treatment group and 55 in the injection treatment group. The mean age of the patients was 8.21 years. The frequency distribution of patients in both groups was evaluated by gender. In the oral treatment group, 22 (40.7%) were male, and 15 (27.3%) were male. Which was not statistically significant (p = 0.138)the changes in vitamin D 4 weeks after treatment and 3 months after treatment did not differ by gender and body mass index. (p >0.05). Changes in vitamin D levels 4 weeks after treatment and 3 months after treatment in the oral and injection groups were evaluated by age (less than 8 years old / over 8 years old), which was statistically significant in the oral treatment group. (p >0.05). But in the injection treatment group, the increase in vitamin D after 4 weeks was significantly greater in the age of 8 and less compared to the age of greater than 8 years (27.60 vs. 20.85 and p = 0.048,). In Long-term, 3 months later, there was no difference. (p>0.05) Conclusion: The results of the present study and previous studies show that both oral and injectable vitamin D therapy is equally effective in treating this deficiency in children. However, our study has shown that in younger children, injectable form in the short term yields a better response, but further studies with larger sample sizes are needed to generalize these results.
Label Free DNA Detection Techniques Using Dielectric Modulated FET: Inversion or Tunneling?

In this paper, a feasibility estimation of inversion and tunneling based n-type dielectric modulated transistor has been extensively carried out for label free DNA detection. The sensing ability of the devices are investigated based on shift in threshold voltage and on-current (<inline-formula> <tex-math notation="LaTeX">$I_{on}$ </tex-math></inline-formula>) with respect to change in permittivity, angle of orientation, and negative charge density of DNA biomolecules. The investigation results show that n-channel Tunneling Field Effect Transistor (TFET) has better sensing capability than n-channel Inversion Mode Field Effect Transistor (IMFET) without compromising on scaling issues. When DNA biomolecules are anchored in the nanogap region, the n-channel IMFET exhibits the shift in threshold voltage and adequate sensitivity. However, it requires a high gate bias to detect the biomolecule. In the case of n-channel TFET, steep subthreshold swing with high <inline-formula> <tex-math notation="LaTeX">$I_{on}$ </tex-math></inline-formula> is observed at low gate bias. Consequently, the sensitivity of TFET is enhanced by 63% when compared with IMFET. This results show TFET devices are superior and can replace the existing IMFET with cost effectiveness. The design and comparative evaluation of the devices are carried out with 2D Silvaco TCAD.
Weighted Phase Retrieval of Fourier Measurement With Outliers: Measurement Structure and Reconstruction Algorithm

Phaseless measurement is widely used in various fields, and phase retrieval is a key step in signal reconstruction of phaseless measurement. The occurrence of outliers will cause the optimal solution of the traditional phase retrieval objective function to deviate from the original signal, thereby reducing the reconstruction accuracy. This article modifies the objective function by introducing a weight vector so that its optimal solution will still approximate the original signal when outliers appear and proposes a specific implementation strategy for this idea under the background of Fourier phase retrieval. For the weight vector, we design a two-channel measurement structure using a discrete Fourier transform frequency-domain cyclic shift theorem and mask technique to obtain a weight vector. For the improved objective function, we use the majorization–minimization framework to derive an iterative algorithm to get an optimal solution. Extensive simulation and hardware experiments show that the proposed method can effectively suppress the adverse effects of outliers.
Bridging Tao Psychotherapy and Person-Centered Psychotherapy: One Psychotherapist’s Journey

This study aims to seek ‘What are the similarities and differences of Tao psychotherapy and person-centered psychotherapy“ by using a biographical narrative approach. The subject summarizes the results, called the psychotherapist who is a native Korean with Western training in Person-centered psychotherapy, exposed to Tao psychotherapy returning to her homeland. Her expertise in both Tao psychotherapy and person-centered experience shows that the similarities are two points that both approaches seek a therapist’s maturing his/her personality, and the therapist’s presence itself can be therapeutic. In terms of differences, issues related to dealing with “self-in-relations”, holistic approach, and format of therapy being brief and directive are presented. Finally, the discussion will be suggested in the context of psychotherapeutic culture and national culture.
Adaptive Spectral–Spatial Multiscale Contextual Feature Extraction for Hyperspectral Image Classification

In this article, we propose an end-to-end adaptive spectral–spatial multiscale network to extract multiscale contextual information for hyperspectral image (HSI) classification, which contains spectral feature extraction (FE) and spatial FE subnetworks. In spectral FE aspect, different from previous methods where features are obtained in a single scale, which limits the accuracy improvement, we propose two schemes based on band grouping strategy, and the long short-time memory (LSTM) model is used for perceiving spectral multiscale information. In spatial subnetwork, on the foundation of existing multiscale architecture, the spatial contextual features which are usually ignored by previous literature are successfully obtained under the aid of convolutional LSTM (ConvLSTM) model. Besides, a new spatial grouping strategy is proposed for convenience of ConvLSTM to extract the more discriminative features. Then, a novel adaptive feature combining way is proposed considering the different importance of spectral and spatial parts. Experiments on three public data sets in HSI community demonstrate that our methods achieve competitive results compared with other state-of-the-art methods.
Science Based Stockpile Stewardship, Uncertainty Quantification, and Surrogate Reactions

Stewardship of this nation's nuclear weapons is predicated on developing a fundamental scientific understanding of the physics and chemistry required to describe weapon performance without the need to resort to underground nuclear testing and to predict expected future performance as a result of intended or unintended modifications. In order to construct more reliable models, underground nuclear test data is being reanalyzed in novel ways. To improve the interpretation of these experiments with quantified uncertainties, improved nuclear data is required. As an example, the thermonuclear yield of a device was often inferred through the use of radiochemical detectors. Conversion of the detector activations observed to thermonuclear yield was accomplished through explosion code calculations (models) and a good set of nuclear reaction cross-sections. Because of the unique high-fluence environment of an exploding nuclear weapon, many reactions occurred on radioactive nuclides, for which only theoretically calculated cross-sections are available. Surrogate nuclear reactions at STARS/LIBERACE offer the opportunity to measure cross-sections on unstable nuclei and thus improve the quality of the nuclear reaction cross-section sets. One radiochemical detector that was loaded in devices was mono-isotopic yttrium ({sup 89}Y). Nuclear reactions produced {sup 87}Y and {sup 88}Y which could be quantified post-shot as a ratio more » of {sup 87}Y/{sup 88}Y. The yttrium cross-section set from 1988 is shown in Figure 1(a) and contains approximately 62 cross-sections interconnecting the yttrium nuclides. The 6 experimentally measured cross-sections are shown in Figure 1(b). Any measurement of cross-sections on {sup 87}Y or {sup 88}Y would improve the quality of the cross-section set. A recent re-evaluation of the yttrium cross-section set was performed with many more calculated reaction cross-sections included. « less
Is Vision for Action Unconscious?

Empirical work and philosophical analysis have led to widespread acceptance that vision for action, served by the cortical dorsal stream, is unconscious. I argue that the empirical argument for this claim is unsound. That argument relies on subjects’ introspective reports. Yet on biological grounds, in light of the theory of primate cortical vision, introspection has no access to dorsal stream mediated visual states. It is wrongly assumed that introspective reports speak to absent phenomenology in the dorsal stream. In light of this, I consider a different conception of consciousness’s relation to agency in terms of access. While theoretical reasons suggest that the inaccessibility of the dorsal stream to conceptual report is evidence that it is unconscious, this position begs important questions about agency and consciousness. I propose a broader notion of access in respect of the guidance of intentional agency as the crucial link connecting agency to consciousness.
An Optimized Dielectric-Metal-Dielectric Refractive Index Nanosensor

In this article, a nanoscale refractive index sensor with double rectangular silver slots perpendicularly coupled with a pair of horizontal dielectric-metal-dielectric (DMD) waveguides is proposed. The simulation of the transmission spectra, deploying the finite integration scheme, shows a linear relationship with the refractive index. Parameters of the suggested sensor have been thoroughly optimized to upgrade its sensing competency. The results achieve a maximum sensitivity of 1228.67 nm/RIU and a high resolution of $8.72\times {10^{-7}}$ RIU, making the schematic an attractive option for commercial and research purposes. Additionally, the capability of the nanosensor as a temperature detector is tested and found to be operable for a freezing point as low as −100° C. Also, the device has undergone simulations of undesirable manufacturing defects, which can occur in real-time and has demonstrated a high degree of tolerance. The presented sensor, therefore, can be treated as a notable solution for on-chip gadgets with all these numerous features and shows promise for future development in the plasmonic refractive index sensor domain.
Identification of differentially expressed genes in the commercially important agarophyte, Gracilaria gracilis, following nitrogen deprivation

The red agarophytic alga, Graci/aria gracilis, occurs naturally within Saldahna Bay, South Africa. Graci/aria species are commercially exploited for their hydrocolloid agar, valued at US$132 million per annum (F AO, 2002). G. gracilis is thus a valuable resource for South Africa in terms of generating foreign currency through export. Nitrogen limitation occurring within Saldahna Bay during the summer to autumn months, however, is considered to be the major factor preventing commercial cultivation of G. gracilis. Algae possess various survival mechanisms that generally involve the activation or repression of various gene regulatory systems. Such regulatory systems aid in preserving energetic homeostasis at a cellular level, thereby allowing maximal algal survival during adverse environmental conditions. Microarray technology is a highthroughput global gene analysis tool, allowing for the simultaneous identification of thousands of differentially expressed genes in a single assay. Combined with genomic technologies such as genetic engineering, microarray technology has the potential to identifY genes that confer enhanced in vivo tolerance to a specific stress. In the current investigation, microarray technology was utilized to identifY genes differentially expressed in G. gracilis in response to nitrogen limitation. A total of 39 differentially expressed genes were identified. Ofthe 35 genes that were sequenced, 13 were assigned a putative function based on sequence similarity to genes deposited in various databases. The remaining sequences corresponded to either unknown hypothetical proteins or else had no significant homology to any of the sequences in the databases. Overall, the current investigation has provided a foundation for future research into the biological role(s) of Un ive rsi ty of Ca pe To wn
A Scalable, General Purpose Circuit Model for Vanadium Compensated, Semi-Insulating, Vertical 6H-SiC PCSS

6H-SiC photoconductive semiconductor switches (PCSS) are new alternative of high power microwave (HPM) or RF generators with the special potential of compactness, tunable frequency and pulse width due to the superior material properties. For PCSS behavior investigation including on-resistance and transient, optical absorption, carrier process, and circuit elements are commonly important issues. This brief builds the major physics framework from the expressions of these influence factors considering simplicity and reliability. According to the basic physics models, a scalable, general model of vanadium compensated, semi-insulating (VCSI), vertical 6H-SiC PCSS is constructed in PSpice. The experiments are performed to verify this circuit model. Consequently, the correspondence between the measured results and simulation results proves its applicability.
Biomarker Analysis in A Randomized Phase 2 Study of Panitumumab Versus Cetuximab in Colorectal Cancer (WJOG6510GTR)

Background: The randomized phase II WJOG6510G study demonstrated the non-inferiority of panitumumab to cetuximab in terms of progression-free survival (PFS) in patients with wild-type KRAS exon 2 metastatic colorectal cancer. In this study, we performed exploratory analyses of updated survival data using the KRAS exon 2 and RAS/BRAF statuses. Methods: Patients with wild-type KRAS exon 2 metastatic colorectal cancer who experienced progression after the failure of fluoropyrimidine, oxaliplatin, and irinotecan were randomized to receive panitumumab or cetuximab in combination with irinotecan. An independent central laboratory performed RAS/BRAF testing using a PCR-reverse sequence-specific oligonucleotide method. Results: In the updated analysis of 121 enrolled patients after a median follow-up of 31.3 months, the median PFS was 5.4 months in the panitumumab arm, versus 4.3 months in the cetuximab arm (hazard ratio [HR]=0.68). The median overall survival (OS) times were 14.9 and 12.5 months in the panitumumab and cetuximab arms, respectively (HR=0.68). In 83 analyzed patients, RAS/BRAF testing identified 19 (23%) and 4 patients (5%) with RAS and BRAF mutations, respectively. In the wild-type RAS and BRAF population, trends of better PFS (6.5 months versus 4.6 months; HR=0.57) and OS (15.3 months versus 11.8 months; HR=0.77) were observed for panitumumab. Conclusions: In this updated analysis, panitumumab was associated with a modest survival benefit versus cetuximab in patients with centrally confirmed wild-type KRAS exon 2 metastatic colorectal cancer as well as in the wild-type RAS and BRAF population.
Energy Savvy Network Joining Strategies for Energy Harvesting Powered TSCH Nodes

This article presents methods that enable batteryless energy harvesting powered time-synchronized channel hopping (TSCH) wireless sensor nodes to join a network with less energy wastage. Network joining of TSCH nodes is very power hungry yet inevitable process to form a working wireless sensor network (WSN). Since the energy level from energy harvesting is scarce, energy passive methods are essential. A duty-cycled network joining process in combination with an appropriate capacitor size is proposed here as they are among the factors that can be easily controlled without extra energy. When a node joins the network in a duty-cycled manner, other nodes may join the network during the gap time, which reduces energy wastage of the nodes in waiting. With an appropriate capacitor size, the capacitor can be charged up within a reasonable time and power up the node for a sufficiently long time, which increases the probability to complete the network joining process of the node. With the combination of a join duty cycle of 50% with a 100-mF capacitor, a WSN was successfully formed by two energy harvesting powered wireless sensor nodes in one network joining attempt.
Predesign of a flexible multibody system excited by moving load using a mechatronic system approach

In this paper, a new analytical approach to object oriented modeling is presented for the predesign of a multibody system. We investigate the dynamic behavior of a system of interconnected components using the modeling language Modelica. In engineering, beam-masses are often used as design models. In fact, the considered system is composed of a flexible beam subjected to a moving load and supporting one or more translating elastic subsystems. Each subsystem is controlled by a vibration absorber and the structure is affected dynamically only through the moving character of the load. The problem of calculation of the dynamic response of this system is very important in many engineering applications such as in the predesign and analysis of a robotic portal systems, machine tools and bridge crane systems. The object oriented modeling approach will be presented to demonstrate the importance of this approach to parametric investigation. It will illustrate how subsystems from Modelica Standard Library can be connected to the developed structure in order to study the vibrational behavior of such a system. For validation purpose, results are compared with those reported in the literature.