Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of a novel large-field cone bipolar cell type in the primate retina: Evidence for selective cone connections

Abstract Parallel processing of visual information begins at the first synapse in the retina between the photoreceptors and bipolar cells. Ten bipolar cell types have been previously described in the primate retina: one rod and nine cone bipolar types. In this paper, we describe an 11th type of bipolar cell identified in Golgi-stained macaque retinal whole mount and vertical section. Axonal stratification depth, in addition to dendritic and axonal morphology, distinguished the “giant” cell from all previously well-recognized bipolar cell types. The giant bipolar cell had a very large and sparsely branched dendritic tree and a relatively large axonal arbor that costratified with the DB4 bipolar cell near the center of the inner plexiform layer. The sparseness of the giant bipolar’s dendritic arbor indicates that, like the blue cone bipolar, it does not contact all the cones in its dendritic field. Giant cells contacting the same cones as midget bipolar cells, which are known to contact single long-wavelength (L) or medium-wavelength (M) cones, demonstrate that the giant cell does not exclusively contact short-wavelength (S) cones and, therefore, is not a variant of the previously described blue cone bipolar. This conclusion is further supported by measurement of the cone contact spacing for the giant bipolar. The giant cell contacts an average of about half the cones in its dendritic field (mean ± s.d. = 52 ± 17.6%; n = 6), with a range of 27–82%. The dendrites from single or neighboring giant cells that converge onto the same cones suggest that the giant cell may selectively target a subset of cones with a highly variable local density, such as the L or M cones.
Alpha-Methylacyl-CoA Racemase: A Novel Tumor Marker Over-expressed in Several Human Cancers and Their Precursor Lesions

&agr;-Methylacyl-CoA racemase (AMACR) is a mitochondrial and peroxisomal enzyme involved in the metabolism of branched-chain fatty acid and bile acid intermediates. Recently, AMACR has been demonstrated to be over-expressed in localized and metastatic prostate cancer, suggesting that it may be an important tumor marker. This study examines AMACR expression in a variety of human cancers and their precursor lesions. A survey of online Expressed Sequence Tags (ESTs) and Serial Analysis of Gene Expression (SAGE) databases revealed that AMACR was over-expressed in multiple cancers. The findings were confirmed by AMACR immunohistochemistry performed on several tissue microarrays containing common human tumors, including prostate, colon, and breast. Based on prior work, AMACR protein expression was divided into two categories: negative (negative to weak staining intensity) and positive (moderate to strong staining intensity). AMACR protein over-expression was found in a number of cancers, including colorectal, prostate, ovarian, breast, bladder, lung, and renal cell carcinomas, lymphoma, and melanoma. Greatest over-expression was seen in colorectal and prostate cancer with positive staining in 92% and 83% cases, respectively. AMACR over-expression was present in 44% of breast cancer cases. AMACR was also over-expressed in precursor lesions. Sixty-four percent of high-grade prostatic intraepithelial neoplasia and 75% colonic adenomas demonstrated positive AMACR protein expression. Reverse transcriptase-polymerase chain reaction for AMACR using laser capture microdissected prostate tissue confirmed gene over-expression at the mRNA level. In conclusion, our study suggests that AMACR is potentially an important tumor marker for several cancers and their precursor lesions, especially those linked to high-fat diets.
(EDUCATION AND FREE MARKET: A TROUBLING RELATIONSHIP)

Education is under pressure today from policies vi'hose aim is to turn it from an universal right into a market commodity. These also try to make some educational fields to comply with market procedures. Two important factors reinforce this trend, as this paper shows. Firstly, the discourse from the Economy of the Education as an academic discipline. According to this trend, education is
Stratum adiposum, A Special Structure of the African Catfish Skin (Clarias gariepinus, Burchell 1822)

The skin histology of Clarias gariepinus, a scaleless teleost from south central Africa, is described. The African catfish epidermis is composed of epithelial cells representing 62.3% of volumetric density (Vv), club cells (Vv = 25.7%), mucous cells (Vv = 10.5%) and melanocytes (Vv = 1.4%). Its thickness amounts to approximately 240 μm. The dermis is distinguished by two well differentiated layers, the stratum adiposum, containing prominent amounts of adipose tissue, which forms large, oblong compartments circumscribed by dense connective tissue, and the stratum compactum, which is rich in compacted collagen fibres. Compared with other catfish species the dermis thickness is considerably thicker ranging from 1.3 to 2.3 mm. The function of this type of skin is discussed.
Symmetrical digital gangrene after a high dose intravenous infusion of epinephrine and dopamine following resuscitation from cardiac arrest

Symmetrical digital gangrene (SDG) is mostly due to low cardiac output and disseminated intravascular coagulation (DIC) (table 1). 1 We describe a 36-year-old right-handed man with SDG requiring amputation of 14 digits. He had received continuous intravenous infusion of epinephrine and dopamine given for a cardiac arrest that developed 1 hour after resection of a meningioma (table 2). In cardiogenic shock, he had decreased responsiveness, sinus tachycardia (135 bpm) and arterial hypotension (50/45 mm Hg). Advanced cardiac life support with mechanical ventilatory support was instituted. The administration of inotropic agents stabilised blood pressure to around 110/65, heart rate at 98 and mean arterial pressure (MAP) at 70 mm Hg. The patient's responsiveness improved gradually, but cardiovascular instability made him inotropic dependant. View this table: Table 1 Causes of symmetrical digital gangrene View this table: Table 2 Drug therapy On day 3 postcardiac arrest, acute gangrene of the tips of 10 toes and right 4 fingers developed. There was painful inflammatory oedema with erythematous reaction in the regions of demarcation between the normal and the gangrenous areas. All …
Restoration of Dlk1 and Rtl1 Is Necessary but Insufficient to Rescue Lethality in Intergenic Differentially Methylated Region (IG-DMR)-deficient Mice*

In the Dlk1-Dio3 imprinted domain, an intergenic differentially methylated region (IG-DMR) regulates the parental allele-specific expression of imprinted genes. The maternally inherited deletion of IG-DMR (IG-DMR(−/+)) results in perinatal lethality because of the overexpression of paternally expressed genes and repression of maternally expressed noncoding RNAs (ncRNAs), including Gtl2. To better understand the possible contribution of paternally expressed genes to the lethality, we attempted to rescue the lethality of IG-DMR(−/+) mutants by restoring the paternally expressed genes. Because the paternally inherited Gtl2 deletion (Gtl2(+/−)) induced a decrease in the expression of paternally expressed genes, we crossed female IG-DMR heterozygous mice and male Gtl2 heterozygous mutant mice. The resultant IG-DMR(−/+)/Gtl2(+/−) double mutant mice had normal expression levels of paternally expressed genes, and none of them showed perinatal lethality; however, most mice showed postnatal lethality with decreased expression of the maternally expressed ncRNAs. Thus, we inferred that paternally expressed genes are necessary for perinatal survivability and that maternally expressed ncRNAs are involved in postnatal lethality.
Relationship of seminal plasma antioxidants and serum male hormones with sperm chromatin status in male factor infertility

We explored the relationship between sperm chromatin integrity, hormone levels, seminal plasma total antioxidant capacity (TAC), and routine sperm parameters in men with male factor (MF, n = 81) and non-male factor (NMF, n = 52) infertility. Semen and blood were collected and examined from men undergoing evaluation for infertility in the Avicenna Infertility Clinic. We have examined each patient for serum hormones (LH, FSH, E2, DHEA), sperm chromatin damage, level of protamination and seminal plasma TAC. Levels of FSH, LH, sperm chromatin damage, and abnormal protamination were significantly higher in MF vs. NMF groups (p < 0.001). Sperm chromatin damage was correlated with percentage of CMA3- positive sperm (r = 0.64, p < 0.001) and with sperm concentration (r = −0.36, p < 0.001), motility (r = −0.21, p < 0.05), and morphologically normal spermatozoa (r = −0.29, p < 0.001). Linear regression showed sperm chromatin damage was related to percentage of CMA3- positive sperm (p < 0.001) in ungrouped patients. It was related to both percentage of CMA3- positive sperm and serum DHEA in the MF group (p < 0.001 and p < 0.05, respectively). Sperm chromatin maturity assessed by CMA3 test was inversely related to sperm chromatin damage assessed by the toludine blue assay. Male factor infertility associated with sperm chromatin damage may be related to sperm protamination and to serum DHEA.
Distributed Resource Reservation in Hybrid MAC With Admission Control for Wireless Mesh Networks

Providing guaranteed quality of service (QoS) for multimedia applications is a challenging topic in wireless mesh networks (WMNs). This paper proposes a distributed resource reservation (RR) mechanism with novel admission control to guarantee QoS performance of real-time sessions (RTSNs) while improving bandwidth utilization in WMNs. The proposed RR mechanism establishes logical clusters (LCs) for identifying interference relationships between nodes and avoids simultaneous transmissions from interfering nodes. Following the established LCs, a cooperative contention and collision-free channel access is achieved in hybrid medium access control (MAC) for multihop data forwarding in WMNs. To efficiently utilize the scarce resources in a contention-free period, soft and hard resources are reserved for RTSNs according to their QoS demands. This is achieved by a novel admission control algorithm. Furthermore, an analytical model is derived for investigating the RR parameters of the proposed mechanism. Simulation results show that the proposed mechanism guarantees the QoS for RTSNs while improving bandwidth utilization.
Identification of Two Novel Coccidian Species Shed by California Sea Lions (Zalophus californianus)

Abstract: Routine fecal examination revealed novel coccidian oocysts in asymptomatic California sea lions (Zalophus californianus) in a rehabilitation facility. Coccidian oocysts were observed in fecal samples collected from 15 of 410 California sea lions admitted to The Marine Mammal Center between April 2007 and October 2009. Phylogenetic analysis using the full ITS-1 region, partial small subunit 18S rDNA sequence, and the Apicomplexa rpoB region identified 2 distinct sequence clades, referred to as Coccidia A and Coccidia B, and placed them in the Sarcocystidae, grouped with the tissue-cyst–forming coccidia. Both sequence clades resolved as individual taxa at ITS-1 and rpoB and were most closely related to Neospora caninum. Coccidia A was identified in 11 and Coccidia B in 4 of 12 sea lion oocyst samples successfully sequenced (3 of those sea lions were co-infected with both parasites). Shedding of Coccidia A oocysts was not associated with age class, sex, or stranding location, but yearlings represented the majority of shedders (8/15). This is the first study to use molecular phylogenetics to identify and describe coccidian parasites shed by a marine mammal.
Hyperbaric oxygen, vasculogenic stem cells, and wound healing.

SIGNIFICANCE Oxidative stress is recognized as playing a role in stem cell mobilization from peripheral sites and also cell function. RECENT ADVANCES This review focuses on the impact of hyperoxia on vasculogenic stem cells and elements of wound healing. CRITICAL ISSUES Components of the wound-healing process in which oxidative stress has a positive impact on the various cells involved in wound healing are highlighted. A slightly different view of wound-healing physiology is adopted by departing from the often used notion of sequential stages: hemostatic, inflammatory, proliferative, and remodeling and instead organizes the cascade of wound healing as overlapping events or waves pertaining to reactive oxygen species, lactate, and nitric oxide. This was done because hyperoxia has effects of a number of cell signaling events that converge to influence cell recruitment/chemotaxis and gene regulation/protein synthesis responses which mediate wound healing. FUTURE DIRECTIONS Our alternative perspective of the stages of wound healing eases recognition of the multiple sites where oxidative stress has an impact on wound healing. This aids the focus on mechanistic events and the interplay among various cell types and biochemical processes. It also highlights the areas where additional research is needed.
Multiliteracies and Multilingualism

The Multiliteracies Project aims to develop a pluralistic educational response to trends in the economic, civic and personal spheres of life which impact on meaning-making and therefore on literacy. These changes call for a new foundational literacy which imparts the ability to understand increasingly complex language and literacy codes; the ability to use the multiple modes in which those codes are transmitted and put to use; and the capacity to understand and generate the richer and more elaborate meanings they convey (Lo Bianco and Freebody 1997).
Human Milk Research for Answering Questions about Human Health

Concerns regarding human milk in our society are diverse, ranging from the presence of environmental chemicals to the health of breastfed infants and the economic value of breastfeeding to society. The panel convened for the Technical Workshop on Human Milk Surveillance and Biomonitoring for Environmental Chemicals in the United States, held at the Hershey Medical Center, Pennsylvania State College of Medicine, on 24–26 September 2004, considered how human milk research may contribute to environmental health initiatives to benefit society. The panel concluded that infant, maternal, and community health can benefit from studies using human milk biomonitoring. Unlike other biological specimens, human milk provides information regarding exposure of the mother and breastfed infant to environmental chemicals. Some of the health topics relevant to this field of research include disorders of growth and development in infants, cancer origins in women, and characterization of the trend of exposure to environmental chemicals in the community. The research focus will determine the design of the study and the need for the collection of alternative biological specimens and the long-term storage of these specimens. In order to strengthen the ability to interpret study results, it is important to identify reference ranges for the chemicals measured and to control for populations with high environmental chemical exposure, because the amount of data on environmental chemical levels in human milk that is available for comparison is extremely limited. In addition, it will be necessary to validate models used to assess infant exposure from breastfeeding because of the variable nature of current models. Information on differences between individual and population risk estimates for toxicity needs to be effectively communicated to the participant. Human milk research designed to answer questions regarding health will require additional resources to meet these objectives. We thank the following organizations for generously providing support for the workshop: the American Chemistry Council; the Centers for Disease Control and Prevention (C13/CCU323635-01); the Department of Health and Human Services, Health Resources and Services Administration (HHSH240200415021P); Health Canada (H405-03-ExSD079/4500078209); 3M; Pennsylvania State University College of Medicine; the Research Foundation for Health and Environmental Effects; and the U.S. Environmental Protection Agency, Office of Children’s Health (CH-83213101-0). The opinions expressed in this article are those of the authors and do not necessarily reflect the views and/or policies of their affiliations.
On the Relationship of Coral Allene Oxide Synthase to Catalase

A heme domain of coral allene oxide synthase (cAOS) catalyzes the formation of allene oxide from fatty acid hydroperoxide. Although cAOS has a similar heme active site to that of catalase, cAOS is completely lacking in catalase activity. A close look at the hydrogen-bonding possibilities around the distal His in cAOS suggested that the imidazole ring is rotated by 180° relative to that of catalase because of the hydrogen bond between Thr-66 and the distal His-67. This could contribute to the functional differences between cAOS and catalase, and to examine this possibility, we mutated Thr-66 in cAOS to Val, the corresponding residue in catalase. In contrast to the complete absence of catalase activity in wild type (WT) cAOS, T66V had a modest catalase activity. On the other hand, the mutation suppressed the native enzymatic activity of the formation of allene oxide to 14% of that of WT cAOS. In the resonance Raman spectrum, whereas WT cAOS has only a 6-coordinate/high spin heme, T66V has a 5-coordinate/high spin heme as a minor species. Because catalase adopts a 5-coordinate/high spin structure, probably the 5-coordinate/high spin portion of T66V showed the catalase activity. Furthermore, in accord with the fact that the CN affinity of catalase is higher than that of WT cAOS, the CN affinity of T66V was 8-fold higher than that of WT cAOS, indicating that the mutation could mimic the heme active site in catalase. We, therefore, propose that the hydrogen bond between Thr-66 and distal His-67 could modulate the orientation of distal His, thereby regulating the enzymatic activity in cAOS.
The Type B Behavior Pattern as a Moderating Variable of the Relationship between Stressor Chronicity and Health Behavior

To test the hypotheses that Type B individuals would engage in more preventive and less risk-related behaviors under high stress than Type As, 155 students were administered questionnaires pertaining to the TABP, daily hassles, and health behavior. As predicted, in six out of seven regression analyses, Type Bs engaged in more preventive, and fewer risk-related behaviors under high stress, than those who self-reported as Type A. Self-regulation mechanisms are proposed to help account for these effects.
Methods of dynamic scaling with VM for high availability server clusters

We propose VM placement control methods to select VM addition server, and to select movement server of VM. We consider to keep redundancy for server trouble. We confirm that proposed methods can control VM in accordance with the state of each server without increasing servers more than required even if VM added at random. We implement a new scheduling method by the proposed methods in OpenStack and confirm scheduling is changed.
DEBATING THE SHARING ECONOMY

The " sharing economy " has attracted a great deal of attention in recent months. Platforms such as Airbnb and Uber are experiencing explosive growth, which, in turn, has led to regulatory and political battles. Boosters claim the new technologies will yield utopian outcomes—empowerment of ordinary people, efficiency, and even lower carbon footprints. Critics denounce them for being about economic self-interest rather than sharing, and for being predatory and exploitative. Not surprisingly, the reality is more complex. This essay, based on more than three years of study of both non-profit and for-profit initiatives in the " sharing economy, " discusses what's new and not so new about the sector and how the claims of proponents and critics stack up. While the for-profit companies may be " acting badly, " these new technologies of peer-to-peer economic activity are potentially powerful tools for building a social movement centered on genuine practices of sharing and cooperation in the production and consumption of goods and services. But achieving that potential will require democratizing the ownership and governance of the platforms.
Analysis on optical properties for various types of light emitting diode

In this paper, comparison on wall-plug efficiency for the infrared (IR) emitter, warm-white LED and multi-chips LED has been studied. The main objective of this work is to provide a specific reference on wall-plug efficiency between various types of LED. Optical measurement is carried out at constant current of 1.0A under ambient temperature of 26.0 ± 1.0oC. It is found that IR emitter offers the highest wall-plug efficiency (34.5%) compared to warm-white LED (18.4%) and multi-chips LED (29.3%). In addition, influence of forward current on optical power for all the LEDs has also been discussed. As a result, optical power increases with increasing of forward current.
Self-Heating During submicrosecond Current Transients in Pr0.7Ca0.3MnO3-Based RRAM

In filamentary RRAM, the role of self-heating in set/reset (by ion transport) is well established. However, in nonfilamentary Pr0.7Ca0. 3MnO3 (PCMO) RRAM, self-heating during set/reset has not been explored. Recently, we have shown self-heating to explain nonlinearity in dc IV characteristics. In this paper, we present the observation of self-heating using transient current during pulses. We show that the cooling timescale is limited by measurement system timescale (~30 ns). The self-heating-based experimental current transient timescale is longer (50-100 ns) and is not described by simple exponential decay. To explain this behavior, self-heating in PCMO RRAM (where Joule heating and current increase create a positive feedback) is implemented into technology computer aided design simulations. Simulations produce excellent agreement with experiments. Eventually, simulations deviate from experiments when thermally assisted ionic transport during set/reset is not included in the model. To interrupt the continuous self-heating, an n-pulse-train with cooling time between pulses versus single pulse-based set/reset experiment was designed with the same peak bias time. Set/reset effectiveness degrades as n increases while effect of increasing cooling time confirmed a cooling timescale of ~30 ns. Overall, self-heating provides a consistent explanation of the transient currents. Thus, this paper establishes that self-heating considerations must be included for PCMO-based RRAM modeling and design.