Miracle-dz/UniFAR-FTUs huggingface dataset:
Interphase (resting) nuclei, chromosomal vesicles and amitosis

Interphase nuclei iiicluding those of normal aiid malignant fibroblasts probably consist of closely packed, firmly adherent, swollen chromosomes (chromosomal vesicles or karyomeres) . This concept is based on the following considerations. (a) I n early cleavages of invertebrate, fish and ainphibian eggs chromosomes remain separate a t end of anaphase, swell into discrete chromosomal resicles during telophase and then become adherent into coiiipact interphase nuclei. (b) Aberrant chromosomal vesicles a re found in the cytoplasm after cells a re subjected during niitosis to certain agents aiid in some iiialignaiit cells in ordinary hanging drop cultures. ( c ) Loss of adhesion between chromosomal vesicles offers an explanation for the iiiechaiiics of amitosis, partial cleavage and fragment at ion of int erphase nuclei without c ~ topla smic cleavage. (d) It helps to explain certain nuclear phenomena of normal aiid malignant fibroblasts and other cells, namely, (1) shrinkage of indiridual chromosomes during prophase and swelling of the daughter chromosome mass during telophase; (2) The maintenance of nucleolar patterns (number, location, size, shape) during interphase because adhesion of chromosomal vesicles would prevent nucleolar shifting; and (3) The mainte-
A Comprehensive Review on International Capital Asset Pricing Models

In concerning with performance evaluation of investment portfolios , various models have been developed. Some of these models are limited to one factor while the others are composed of several f actors. Trend of globalization and expansion of investment activities in different markets led to introdu ce and develop the international capital asset pricing model. This model evaluated the performance of various compone nts of the investment portfolio that has been composed of varieties of currency basis. Furthermore, this m odel predicts the efficiency and effectiveness of a complex portfolio that including investments in various financial marke ts, but those results based on a uniform currency. Finally, it can provide a comprehensive perspective for inv estors in the case of interpretation of results. This paper describes the models of international capital asset pricing (ICAPM) for measurement of risk and return in the international asset returns based on different currencies in global por tfolio, widely-used risk factors such as inflation, exchange rate, and forward premium. In addition, for pr ofound study, the paper reviewed the results of previous and recent studies in this regards.
Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis: A Prospective Study

Background:Prospective data on incidence, characteristics, and risk factors for cryptococcal meningitis immune reconstitution inflammatory syndrome (CM-IRIS) are lacking. Methods:Prospective study of 65 antiretroviral therapy (ART)-naive HIV-infected cryptococcal meningitis (CM) patients, who started ART after initiation of antifungal treatment. CM-IRIS definition: (1) cerebrospinal fluid (CSF) culture-confirmed CM, (2) symptom resolution before starting ART, (3) adherence to fluconazole and ART, (4) recurrence of CM symptoms after starting ART, (5) immunologic and/or virologic response to ART, (6) no alternative diagnosis. Results:ART was started at a median of 47 days from CM diagnosis. CM-IRIS developed in 11 of 65 (17%), at a median 29 days from starting ART. No factors at first CM episode (fungal burden, rate of clearance, CSF, or HIV parameters) predicted those at risk of CM-IRIS. At 6 months on ART, IRIS patients had greater CD4 rise from baseline (220 vs. 124 × 106 cells /L in non-IRIS, P = 0.01), and 4 of 11 CM-IRIS patients died compared with 14 of 54 non-IRIS patients (P = 0.5). For those developing CM-IRIS, CSF proinflammatory cytokines interferon γ, tumour necrosis factor α, and interleukin 6, did not differ between first CM and CM-IRIS episode. Conclusions:Patients with CM-IRIS had greater immune restoration in response to ART. Although common and potentially fatal, larger prospective studies are needed to determine whether CM-IRIS, in patients treated initially with amphotericin B, is associated with any increase in overall mortality.
An acoustic study of penultimate accentuation in three varieties of French

The aim of this paper is to provide an acoustical account of penultimate accentuation in some varieties of French. We compare stretches of spontaneous speech produced by 8 Swiss speakers (4 Neuchâtel speakers and 4 Wallis speakers, hereafter "regional varieties") with the productions of a group of 4 Parisian speakers (hereafter "standard variety"). The results of our study show that penultimate accentuation is less frequent in Parisian French than in the Swiss varieties. More interestingly, the study reveals that the phenomenon has different acoustic correlates not only between the standard variety and the regional varieties, but also within the two regional varieties: while Wallis speakers tend to be closer to Parisian speakers using melodic cues to mark their penultimate syllable as prominent, speakers from Neuchâtel tend to prefer using durational cues to do so.
Kinerja Pengelolaan Dana Pada Pasar Modal Indonesia

The mutual fund is a fast growing, flexible and sizely attainable product, hence make it as favourable choice for the investors. As in other developing countries, however, the management of the fund invested in mutual fund is done by pointed fund manager. This paper raises and answers the question of how efficient the fund management is. This paper ustilizes the decomposition return model on the monthly data set from 2002-2006 in Indonesia. The model derived, enable us to trace and decompose the management performance into (i) the allocation policy skill, (ii) the security selection skill and (iii) the market timing strategy or the tactical asset allocation abilty. The model estimation result shows significant management capabilities on allocating the fund into suitable asset class. We record that the best asset allocation policy was on February 2002, June 2004, August 2004 and February 2006. In line with this, another result shows the negatif contribution of the short term-tactical asset allocation as conformed by several previous studies; Treynor-Mazuy (1996), Wardhani (2003), and Henriksson (1984) among others. There is an exception for February 2006 where a successful market timing strategy contributed an additional 7.34% return. The security selection strategy is confirmed to have a positive and significant impact on the mutual fund performance. During the observation period, the best security selection strategy was achieved on February, March and July 2002, September 2003, and March, October, and December 2005. For these certain period, the security selection activities gave more than 2% additional monthly return. The policy implication is straightforward; a more intensively monitoring on the implementation of the planned asset allocation to give a safer financial investment environment for the investors. This paper also suggest the investment manager to provide a sufficient information about the portfolio’s risk profile. Our quantitative description has shown a large varieties both on return and risk across the mutual fund manager showing their varied risk taking behaviour, on which the investor has a right to know.
Impact of random telegraph noise on ring oscillators evaluated by circuit-level simulations

Random Telegraph Noise (RTN) has become dominant with transistor rapid scaling in recent years. We simulate RTN-induced frequency fluctuation of Ring Oscillators (ROs) using a circuit-level simulator to replicate measurement results from previous works. Consequently, we can predict dependences of frequency fluctuation on operating voltages, number of ROs stages, gate widths, and body biases.
A Decision-Making Framework to Analyze Important Dimensions of M&A Performance

This chapter develops a decision-making framework to analyze important dimensions of mergers and acquisitions. Using a PLS approach, we show that strategic deals’ performance – measured by means of synergy realization, relative performance (compared to the competition), and absolute performance – is determined by three dimensions: strategic logic, organizational behavior, as well as finance. We find that the following significant variables, which stem from each of these dimensions, should be taken into account to ensure a successful deal: market similarities, market complementarities, operational similarities, operational complementarities, market power, purchasing power, acquisition experience, relative size, and due diligence.
Oral Contraceptives and In Vivo Cytogenetic Studies

Cytogenetic studies of peripheral blood lymphocyte cultures were done on 7 young women prior to and after 1 and 2 months of oral contraceptive use. No significant change in chromosome breaks or mitotic index was revealed when each of the 7 women served as her own control nor when findings in 4 additional young women who had been using oral contraceptives for more than 3 years were compared to those from 4 controls. These results differ from several other studies in vivo which did not use each patient as her own control.
Active power injection control of a photovoltaic system through ultracapacitor storage

This document presents a three-phase grid-connected power injection system for a photovoltaic power source with control of the injected active power through an energy storage system based on ultracapacitors. The ultracapacitor technology offers high power density that matches properly in a Smart-Grid scenario with the need of active power regulation for quasi-manageable energy ability. A voltage source inverter injects the power into the grid, while a bidirectional direct current converter regulates the charge of the ultracapacitor. In this way, the ultracapacitor could be charged when the active power needed in the grid is below the photovoltaic power, it could be discharged in the opposite case, and, if the ultracapacitor is saturated the power point tracked depends on the reference, injecting the desired active power in every assumption. The system has been implemented in a prototype through a FPGA/processor controller, so the hardware/software co-design is detailed. Finally, the performance of the configuration is exposed via experimental tests.
A Novel Method for Partially Adaptive Broadband Beamforming

In this paper, a novel subband-selective generalized sidelobe canceller (GSC) for partially adaptive broadband beamforming is proposed. The blocking matrix of the GSC is constructed such that its columns constitute a series of bandpass filters, which select signals with specific angles of arrival and frequencies. This results in bandlimited spectra of the blocking matrix outputs, which is further exploited by a subband decomposition prior to running independent unconstrained adaptive filters in each non-redundant subband. We discuss the design of both the blocking matrix using a genetic algorithm for an efficient sum-of-power-of-two coefficient format and the filter bank for the subsequent subband decomposition. By these steps, the computational complexity of our subband-selective GSC is greatly reduced compared to other adaptive GSC schemes, while performance is comparable or even enhanced due to subband decorrelation, as simulations indicate.
New Trends in Service Science and Education for Service Innovation

Service science is a new trans-disciplinary science and technology in the 21st century. In this chapter, firstly, new definitions of service and new directions for service are described for innovations in various industries. Service science should cover not only traditional service industries but also important basic industries such as information or manufacturing industries. Then, the importance of a system’s approach to creating service values is emphasized. In particular, system science and knowledge science are important from the viewpoint of maximizing service value. Finally, education for service innovation considering such trends is proposed and evaluated by implementing it as a management course for professionals in business.
Upending the Uncanny Valley

Although robotics researchers commonly contend that robots should not look too humanlike, many artforms have successfully depicted people and have come to be accepted as great and important works, with examples such as Rodin's Thinker, Mary Cassat's infants, and Disney's Abe Lincoln simulacrum. Extending this tradition to intelligent robotics, the authors have depicted late sci-fi writer Philip K Dick with an autonomous, intelligent android. In doing so, the authors aspire to bring robotic systems up to the level of great art, while using the technology as a mirror for examining human nature in social AI development and cognitive science experiments.
Tau numbers, natural density, and Hardy and Wright's theorem 437

An element of the set T= {n:τ(n) is a factor of n} is called a Tau number, where τ(n) denotes the number of divisors of the integer n. We determine the natural density of this set by use of Hardy and Wright's Theorem 437 (4th ed.).
Plasma total homocysteine: instigator or indicator of cardiovascular disease?

Abstract Cardiovascular disease (CVD) is a major cause of morbidity and mortality in developed countries. However, traditional risk factors cannot fully account for this. In the last 20 years, there has been an explosion of interest in plasma total homocysteine (tHcy) as a potential modifiable risk factor for CVD. Recent meta-analyses of epidemiological studies support the concept that increased tHcy concentrations are associated with CVD. This has led to the ‘homocysteine hypothesis’, which states that lowering plasma tHcy using folic acid and other B-vitamins will reduce the risk of CVD. In experimental studies, homocysteine has been shown to cause oxidative stress, endothelial cell dysfunction and promote thrombogenesis. However, data from recent large randomized controlled trials have shown that there is no clinical benefit to lowering plasma tHcy concentrations with folic acid and other B-vitamins. This lack of effect of tHcy lowering strongly suggests that homocysteine is not an instigator but merely an indicator of CVD.
Perceptions on organic farming and selected organic fertilizers by subsistence farmers in Ga-Rankuwa, Pretoria, South Africa

Organic farming, which is a form of alternative or sustainable agriculture, makes a major contribution to the improvement of food security globally through recycling of natural resources. This study assessed 60 subsistence farmers’ perceptions of organic farming. Descriptive statistical analyses of randomly selected subsistence farmers indicated that the majority of respondents (80.0%) had previous knowledge of organic farming but had failed to practise it because they could not afford it. In addition, they thought organic fertilizers, such as dry sewage, human faeces and human urine were unacceptable because of their smell, their unhygienic nature and the respondents’ fear of disease epidemics. The female respondents’ order of decreasing preference for organic fertilizers was animal droppings > animal urine > human faeces > sewage > human urine, whereas for males it was chicken droppings > cow dung > animal urine > sewage and human urine > human faeces. Respondents with no high school education regarded chicken droppings most positively as an organic fertilizer (93.2%), followed by cow dung (84.1%), animal urine (66.0%) and human urine (27.3%), whereas the majority of respondents with tertiary education preferred sewage and human faeces as organic fertilizers. Fifty per cent of the respondents showed a willingness to convert to organic farming, dependent on the availability of information and education.
Characterization of a transcription factor involved in mother cell specific transcription of the yeast HO gene.

The yeast HO gene, which encodes an endonuclease involved in initiating mating type interconversion, is expressed in mother cells but not in daughters. It has been demonstrated that the SWI5 gene, which is an activator of HO expression, plays a critical role in this differential mother/daughter expression of HO. In this paper we describe the cloning and sequencing of the SWI5 gene. The predicted amino acid sequence derived from the cloned SWI5 gene shows homology with the repeated DNA‐binding domains (‘zinc fingers’) of Xenopus transcription factor TFIIIA. A region of the HO promoter involved in the SWI5‐dependent transcriptional activation of HO was identified by deletion analysis of the HO promoter in the chromosome, and by testing the ability of HO DNA fragments to activate transcription in the context of a heterologous promoter. The SWI5 gene product was overproduced in yeast from the GAL1‐10 promoter, since the SWI5 protein is made at very low levels in wild‐type strains, and protein extracts were used to demonstrate that the SWI5 protein binds in vitro to a segment of the HO promoter required for transcriptional activation in vivo.
Bacteriological survey of tuberculous lymphadenitis in southeast England, 1981-1989.

STUDY OBJECTIVE--The aim was to detect any changing trends in the nature and incidence of tuberculous lymphadenitis in southeast England and to determine whether there is any evidence for an increase in this disease that could be related to HIV infection. DESIGN--Mycobacteria isolated from patients with lymphadenitis in the years 1981 to 1989 were identified. Information was available on the age, sex, and ethnic origin of the patients and the anatomical site from which the mycobacterium was isolated. SETTING--The Public Health Laboratory Service Regional Tuberculosis Centre at Dulwich, which receives over 95% of mycobacteria isolated in southeast England. MAIN RESULTS--From 1980 to 1989, cultures were received from 1817 patients with mycobacterial lymphadenitis: 1677 were M tuberculosis, 25 M bovis, 21 M africanum, and 94 were other (environmental) species. In comparison with a survey conducted in the same region in 1973-80, the number of ethnic Indian subcontinent patients with lymphadenitis due to M tuberculosis had dropped by 30% and the number of European patients had dropped by 43% and showed a continuing decline and a shift towards an older age group. By contrast, there was a 20% increase in the number of cases due to environmental mycobacteria. The number of species causing such infections had increased and a greater proportion of patients were adults. Three patients infected by environmental mycobacteria were known to be HIV positive. CONCLUSIONS--The incidence of lymphadentis due to M tuberculosis is declining but cases due to environmental mycobacteria are increasing, with a greater diversity of species and more adult patients. There is no conclusive evidence for an impact of HIV infection on the incidence and nature of mycobacterial lymphadenopathy in southeast England, but this cannot be ruled out.
The Motivations for Adopting Sustainability Disclosure

The aim of this paper is to explore the literature regarding sustainability and extended reporting frameworks, to catalogue various typologies of reporting frameworks, to investigate the motivation by organisations to adopt such frameworks, and to identify the extent of their use in Australia. We start by defining corporate social responsibility (CSR) and sustainability and provide a brief overview of the historical development of the concepts of sustainability. Key to this is understanding stakeholders and their importance as a motivator for organisations to adopt sustainability reporting frameworks. We outline the background to the development of new reporting frameworks by examining the academic literature in the area of sustainability research. We identify and catalogue 11 new reporting and social accounting guidelines, and focus on the development of one particular framework, the Global Reporting Initiative (GRI), and investigate the extent of its use in Australia. We find the motivation for adopters of sustainability reporting frameworks is to attempt to communicate with their stakeholders the performance of management in achieving long-run corporate benefits, such as improved financial performance, increased competitive advantage, profit maximisation, and the long-term success of the firm.
VPN Enterprise Network Construction Based on Security

It first introduces widespread emergence of network the branches increased and security issues during the enterprise development and internationalization process. To use the VPN technology for network construction based on a comprehensive analysis the enterprise network system requirements and security requirements. It designed commercial IPsec VPN network security based on third layer (network layer), and IPsec security system construction structure. It formed enterprises. In reduces the cost. At the same time, it effectively improves the convenience and safety of enterprise network security.
Knowledge Intensive Business Services and Regional Policy

The economic importance of the Knowledge Intensive Business Services (KIBS) sector is increasing as its direct share of production grows, and as it increasingly provides knowledge inputs to firms in other sectors within more open innovation strategies. This chapter considers the implications for regional policy. It starts by discussing the nature of KIBS and their role in innovation. It then examines the changing scale of KIBS and the extent to which they are regionally concentrated. Key messages from neoclassical growth theory are then set out on the processes through which KIBS can be expected to contribute to regional economic growth, including discussion of potential cumulative causation processes at regional level. The implications of the theory are drawn out in terms of the types of market failures that policy should seek to address and how it may do so. The question is also posed of whether this is largely a field for regional policy or for national innovation policy. The chapter concludes by identifying some important questions for further research.
Variety in hybridity in sport organizations and their coping strategies

Abstract The governance of national governing bodies of sports such as sport federations is becoming increasingly complex. An important driver of this is the widening of the scope of activities of these federations, from servicing local sports clubs or providing sport activities, to involvement in professional sports and media businesses and aspiring to a wider social role in accordance with governmental objectives. This development is analysed from the viewpoint of hybridization of organizations. Hybridity appears when organizations cannot (or can no longer) be described as completely belonging to the civil communities, private sector, or state sector and become an organization containing a mix of sectorial, structural, and/or mission related elements. Quantitative and qualitative data is used to analyse how many of the national sport federations become more hybrid in their goals, use of resources, governance model and even in their identity. Since hybridity can create problematic tensions and governance dilemmas, the way in which the federations react to this development has also been studied. Hybridity has consequences for the role of different stakeholders in the governance process. Not all federations are involved in hybridization, but if they are, they are capable of coping with this by adapting their strategy. Some of them, however, are opting to develop into branch organizations and become fully hybrid organizations.