Miracle-dz/UniFAR-FTUs huggingface dataset:
The circadian rhythm of the perinatal mortality rate in Switzerland.

The authors examine the relation between the perinatal mortality rate (PMR), birth weight in four categories, and hour of birth throughout the week in Switzerland, using data on 672,013 births and 5,764 perinatal deaths recorded between 1979 and 1987. From Monday to Friday, the PMR follows a circadian rhythm with a regular increase from early morning to evening, with a peak for babies born between 7 and 8 p.m. This pattern of variation has two main components: The circadian rhythms for the proportion of births in the four weight categories and the PMR circadian rhythm for babies weighing more than 2.5 kg. According to a cosinor model, which describes about 40% of the total variation in the PMR, the most important determinants are changes in the proportions of births: Low birth weight increases toward the afternoon and night. Mechanisms underlying the weight-specific timing of birth are discussed, including time selection of birth according to obstetric risks, the direct effect of neonatal and obstetric care, and chronobiologic behavior.
Dynamic clustering for multicell cooperative processing in mobile communications

Multicell cooperative processing (MCP) has been recognized as a promising technique for enhancing the spectral efficiency of future wireless systems. However, MCP inevitably requires increased radio feedback and backhaul overhead. Therefore, only a limited number of base stations can cooperate for an affordable system complexity in practice. In this paper, we propose a novel dynamic clustering scheme for the cellular system incorporating MCP. The clusters are formed dynamically from users' point of view to minimize the co-channel interference, and are allowed to be overlapped. The objective of the clustering scheme is rate maximization of the cell-edge users. Compared with some conventional cooperation clustering schemes, the proposed scheme has proven to provide a good trade-off between user rates and overhead. Simulation results show that the user rates of the proposed scheme with a cluster consisting of two sectors can reach up to 95% of its upper bound.
The effects of wetland habitat structure on Florida apple snail density

Wetlands often support a variety of juxtaposed habitat patches (e.g., grass-, shrub- or tree-dominated) differentially suited to support the inhabiting fauna. The proportion of available habitat types has been affected by human activity and consequently has contributed to degrading habitat quality for some species. The Florida apple snail (Pomacea paludosa) has drawn attention as a critical prey item for wetlands wildlife and as an indicator of wetlands restoration success in peninsular Florida, USA. An apparent contradiction has evolved wherein this species appears intolerant of drying events, but these disturbances may be necessary to maintain suitable habitat structure for apple snails. We recently reported that assertions regarding intolerance to dry downs in this species were inaccurate. Here, we compared snail density in habitats with (wet prairie) and without (slough) emergent macrophytes, as well as evaluating the effects of structural attributes within the broad wet prairie habitat type. Snail densities were greater in prairies relative to sloughs (χ2= 12.90, df= 1, P=0.0003), often by a factor of two to three. Within wet prairie habitats, we found greater snail densities in Panicum hemitomon as compared to Eleocharis cellulosa (χ2=31.45, df=1, P=0.0001). Significantly fewer snails were found in dense E. cellulosa as compared to habitats with lower stem density (χ2= 10.73, df=l, P=0.011). Our results indicate that wet prairie habitat supports greater snail densities than Nymphaea- dominated slough. Our results have implications for wetlands water management in that continuous inundation has been shown to convert wet prairie to slough habitat, and we suggest this should be avoided in support of apple snails and their predators.
Comparison of natural adsorbents for metal removal from acidic effluent

Abstract Adsorption tests were carried out in acidic synthetic solutions (pH 2.0) using 20 g 1‐1 of various natural adsorbents and 0.25 mM of 11 different metals. In decreasing order, the most efficient adsorbents tested were: oyster shells, cedar bark, vermiculite, cocoa shells and peanut shells. In contrast, weak metal adsorption was demonstrated by: red cedar wood, peat moss, pine wood, corn cobs and perlite. Metal adsorption capacities in acidic synthetic solution followed the order Pb2+> Cr3+> Cu2+> Fe2+> A13+> Ni2+> Cd2+> Mn2+> Zn2+>> Ca2+, Mg2+. Alkaline treatment (0.75 M NaOH) increased the effectiveness of metal removal for the majority of adsorbents. In contrast, acid treatment (0.75 M H2SO4) either reduced or did not affect the adsorption capacity of the materials tested. Finally, oyster shells, red cedar wood, vermiculite, cocoa shells and peanut shells, were effective natural adsorbents for the selective recovery of lead and bivalent chromium from acidic effluent.
Mating patterns, relatedness and the basis of natal philopatry in the brown long‐eared bat, Plecotus auritus

The brown long‐eared bat, Plecotus auritus, is unusual among temperate zone bats in that summer maternity colonies are composed of adult males and females, with both sexes displaying natal philopatry and long‐term association with a colony. Here, we describe the use of microsatellite analysis to investigate colony relatedness and mating patterns, with the aim of identifying the evolutionary determinants of social organization in P. auritus. Mean colony relatedness was found to be low (R = 0.033 ± 0.002), with pairwise estimates of R within colonies ranging from −0.4 to 0.9. The proportion of young fathered by males in their own colony was investigated using a Bayesian approach, incorporating parameters detailing the number of untyped individuals. This analysis revealed that most offspring were fathered by males originating from a different colony to their own. In addition, we determined that the number of paternal half‐sibs among cohorts of young was low, inferring little or no skew in male reproductive success. The results of this study suggest that kin selection cannot account for colony stability and natal philopatry in P. auritus, which may instead be explained by advantages accrued through the use of familiar and successful roost sites, and through long‐term associations with conspecifics. Moreover, because the underlying causes of male natal dispersal in mammals, such as risk of inbreeding or competition for mates, appear to be avoided via extra‐colony copulation and low male reproductive skew, both P. auritus males and females are able to benefit from long‐term association with the natal colony.
Connecting Supreme Court Decisions, Media Coverage, and Public Opinion: The Case of Lawrence v. Texas

Many scholars have examined the relationship between public opinion and the U.S. Supreme Court, but most researchers have often failed to take into account the fact that the press mediates this relationship. Due to the public’s lack of independent knowledge about Supreme Court decisions, the media has the potential to play an influential role in the communication and interpretation of Supreme Court decisions. In this article, we examine the relationship between the Supreme Court, the media, and public opinion. First, we examine whether increased public tolerance on gay and lesbian issues has resulted in increased media coverage of gay-related cases before the Supreme Court. Second, we examine how media coverage of the Court’s 2003 decision to strike down state sodomy laws in Lawrence v. Texas may have been associated with decreased public support for gay and lesbian civil rights. Our analysis suggests that increased support for gay and lesbian civil rights may have lead to increased media attention to the Lawrence case and that the tone of this coverage may have subsequently resulted in an observed decrease in support for gay and lesbian civil rights following the Court’s decision. We also suggest that the release of a highly critical dissenting opinion by the Court in the case may have encouraged negative media coverage and the resulting shift in public opinion. Our research has broad implications for media coverage of Supreme Court decisions.
Role of nitric oxide as an inhibitory neurotransmitter in the canine pyloric sphincter.

Experiments were performed to test the hypothesis that enteric inhibitory neurotransmission in pyloric muscles is mediated by NO. Junction potentials were recorded with intracellular microelectrodes from cells near the myenteric and submucosal surfaces of the circular muscle layer. Inhibitory junction potentials (IJPs) were apamin sensitive and were reduced by arginine analogues [NG-nitro-L-arginine-methyl ester (L-NAME) and NG-monomethyl-L-arginine (L-NMMA)]. The effects of arginine analogues were reversed by L-arginine. Inhibition of IJPs unmasked excitatory JPs (EJPs) in the myenteric region and increased excitability of cells in the submucosal region. IJPs were also reduced by oxyhemoglobin. As with arginine analogues, reduction in IJPs increased EJP amplitude. Combination of L-NAME and oxyhemoglobin completely blocked IJPs, suggesting that NO, or an NO-containing compound, mediated the enteric inhibitory nerve responses. Exogenous NO hyperpolarized membrane potential, and these responses were also reduced by apamin. The magnitude of the responses to a given dose of NO was similar in cells of the myenteric and submucosal regions, suggesting that relatively smaller IJPs in submucosal cells may be due to a lower density of enteric inhibitory innervation in the submucosal region. The effects of NO were mimicked by 8-bromoguanosine 3',5'-cyclic monophosphate (cGMP) and M & B 22948, a specific cGMP phosphodiesterase inhibitor, suggesting that the hyperpolarization response to NO may be mediated by enhanced production of cGMP. IJPs were also prolonged by M & B 22948. IJPs and NO disrupted normal electrical rhythmicity in cells in the myenteric region. This may provide a basis for inhibitory effects of enteric inhibitory nerve stimulation on sphincter pressure in pyloric canal in vivo. (ABSTRACT TRUNCATED AT 250 WORDS)
Synopsis: Economy-wide impacts of the Productive Safety Net Programme (PSNP)

The findings from this study reveal that, on an economy-wide ba-sis, the benefits of PSNP significantly exceed the cost of PSNP transfers. New income created by PSNP benefits households that do not receive cash transfers; these non-beneficiaries benefit as markets transmit PSNP impacts to them through local and national markets. Documenting the total benefits, including benefits to non-beneficiaries, is critical to garner support for PSNP. Our analysis shows that PSNP achieves both social and productive goals by raising income in beneficiary households while stimulating local and national production. This should be good news to both finance and social welfare ministries.
Cardiac myosin-induced myocarditis. Heart autoantibodies are not involved in the induction of the disease.

We recently demonstrated that cardiac myosin is capable of inducing autoimmune myocarditis in genetically predisposed mice. This disease parallels coxsackievirus B3-induced autoimmune myocarditis in many respects and is associated with high-titer autoantibodies specific for cardiac myosin. The following lines of evidence suggest that these autoantibodies are not involved in the induction of autoimmune myocarditis: 1) immunoperoxidase staining of heart sections from cardiac myosin-immunized A/J and A.SW mice revealed IgG depositions only along damaged muscle fibres in infiltrated areas, but not in intact tissue; 2) myosin autoantibodies did not bind to the surface of viable cardiac myocytes isolated from mice, but only reacted with myocytes permeabilized with detergent; 3) mice treated with a single high dose of cyclophosphamide, which reduces the humoral immune response, still developed severe myocarditis, despite the fact that their autoantibody titers were reduced to the level of adjuvant-injected controls; and 4) passive transfer of high-titer myosin autoantibodies failed to induce myocarditis, although the titers in the recipients were comparable to those found in mice with cardiac myosin-induced disease. Together, the results suggest that high-titer myosin autoantibodies are secondary rather than primary to the disease.
Dynamic Glycosylation of Nuclear and Cytosolic Proteins

O-Linked N-acetylglucosamine (O-GlcNAc) glycosylation is a dynamic modification of eukaryotic nuclear and cytosolic proteins analogous to protein phosphorylation. We have cloned and characterized a novel gene for an O-GlcNAc transferase (OGT) that shares no sequence homology or structural similarities with other glycosyltransferases. The OGT gene is highly conserved (up to 80% identity) in all eukaryotes examined. Unlike previously described glycosyltransferases, OGT is localized to the cytosol and nucleus. The OGT protein contains multiple tandem repeats of the tetratricopeptide repeat motif. The presence of tetratricopeptide repeats, which can mediate protein-protein interactions, suggests that OGT may be regulated by protein interactions that are independent of the enzyme's catalytic site. The OGT is also modified by tyrosine phosphorylation, indicating that tyrosine kinase signal transduction cascades may play a role in modulating OGT activity.
Arabidopsis Enhanced Drought Tolerance1/HOMEODOMAIN GLABROUS11 Confers Drought Tolerance in Transgenic Rice without Yield Penalty1[W][OA]

AtEDT1/HDG11 improves stress tolerance and grain yield in rice. Enhancing drought tolerance without yield decrease has been a great challenge in crop improvement. Here, we report the Arabidopsis (Arabidopsis thaliana) homodomain-leucine zipper transcription factor Enhanced Drought Tolerance/HOMEODOMAIN GLABROUS11 (EDT1/HDG11) was able to confer drought tolerance and increase grain yield in transgenic rice (Oryza sativa) plants. The improved drought tolerance was associated with a more extensive root system, reduced stomatal density, and higher water use efficiency. The transgenic rice plants also had higher levels of abscisic acid, proline, soluble sugar, and reactive oxygen species-scavenging enzyme activities during stress treatments. The increased grain yield of the transgenic rice was contributed by improved seed setting, larger panicle, and more tillers as well as increased photosynthetic capacity. Digital gene expression analysis indicated that AtEDT1/HDG11 had a significant influence on gene expression profile in rice, which was consistent with the observed phenotypes of transgenic rice plants. Our study shows that AtEDT1/HDG11 can improve both stress tolerance and grain yield in rice, demonstrating the efficacy of AtEDT1/HDG11 in crop improvement.
International market structure and competitiveness at the malted beer: from 2003 to 2012

Barley malt beer is the world's most consumed alcoholic drink and its industry represents a multibillion dollar international trade. Th e paper's main goal is to contribute with the analysis of this industry in terms of its international competitiveness and market structure. It utilizes the data regarding exports and imports for malted beer available in the International Trade Centre's Trade Map database and it refers to the period of ten years (2003-2012). Th e method used to expose the industry's competitiveness and market structure consisted in the calculation of (i) Revealed Comparative Advantage (RCA); (ii) Relative Position of Market (RPM); (iii) Hirschman-Herfi ndahl index (HHI) and (iv) Net Export In- dex (NEI). Th e fi ndings show a high concentration for both the import and export markets and the detainers of the largest shares are: (1) the United States of America for imports and (2) Mexico, the Netherlands, Belgium and Germany for ex- ports. It was possible to identify the players in the market structure based on exporters, importers and both importers and exporters, stressing their position in the market.
Astrocytic endogenous glial cell derived neurotrophic factor production is enhanced by bone marrow stromal cell transplantation in the ischemic boundary zone after stroke in adult rats

Bone marrow stromal cells (BMSCs) facilitate functional recovery in rats after focal ischemic attack. Growing evidence suggests that the secretion of various bioactive factors underlies BMSCs' beneficial effects. This study investigates the expression of glial cell derived neurotrophic factor (GDNF) in the ischemic hemisphere with or without BMSC administration. Adult male Wistar rats were subjected to 2 h of middle cerebral artery occlusion followed by an injection of 3 × 106 BMSCs (n = 11) or phosphate‐buffered saline (n = 10) into the tail vein 24 h later. Animals were sacrificed seven days later. Single and double immunohistochemical staining was performed to measure GDNF, Ki67, doublecortin, and glial fibrillary acidic protein expression as well as the number of apoptotic cells along the ischemic boundary zone (IBZ) and/or in the subventricular zone (SVZ). BMSC treatment significantly increased GDNF expression and decreased the number of apoptotic cells in the IBZ (P < 0.05). GDNF expression was colocalized with GFAP. Meanwhile, BMSCs increased the number of Ki‐67 positive cells and the density of DCX positive migrating neuroblasts (P < 0.05). GDNF expression was significantly increased in single astrocytes collected from animals treated with BMSCs, and in astrocytes cocultured with BMSCs after OGD (P < 0.05). Our data suggest that BMSCs increase GDNF levels in the ischemic hemisphere; the major source of GDNF protein is reactive astrocytes. We propose that the increase of GDNF in response to BMSC administration creates a hospitable environment for local cellular repair as well as for migrating neuroblasts from the SVZ, and thus contributes to the functional improvement. © 2010 Wiley‐Liss, Inc.
Corporate governance and cost of equity: empirical evidence from Latin American companies

Purpose This paper aims to investigate the extent to which corporate governance (CG) systems adopted by Latin American listed firms affect their cost of equity capital. Several studies on the link between the two aforementioned dimensions have been carried out, but none in the context of Latin American firms. Design/methodology/approach A CG index is created by taking into account the peculiarities of each country and the recommendations given by the corresponding CG institutes. In particular, to assess the level of CG quality, three sub-indexes have been identified: “Disclosure”, “Board of Directors” and “Shareholder Rights, Ownership and Control Structure”. Findings The results indicate a negative relationship between CG quality and the cost of equity. In particular, the “Disclosure” component is the one mostly affecting the cost of equity. Research limitations/implications This study contributes to the literature by adding knowledge on the relationship between CG and cost of capital considering, for the first time, the overall Latin American market. Practical implications The paper proves that institutional investors all over the world are disposed to pay a premium to invest in firms with effective CG standards; moreover, this premium is higher in emerging countries such as those analyzed in this paper, rather than in developed countries. Originality/value To the authors' knowledge, this is the first paper empirically investigating the relationship between CG and cost of capital in Latin America.
The Virulence Regulator Sae of Staphylococcus aureus: Promoter Activities and Response to Phagocytosis-Related Signals

ABSTRACT The two-component system SaeRS of Staphylococcus aureus is closely involved in the regulation of major virulence factors. However, little is known about the signals leading to saeRS activation. A total of four overlapping transcripts (T1 to T4) from three different transcription starting points are expressed in the sae operon. We used a β-galactosidase reporter assay to characterize the putative promoter regions within the saeRS upstream region. The main transcript T2 is probably generated by endoribonucleolytic processing of the T1 transcript. Only two distinct promoter elements (P1 and P3) could be detected within the saeRS upstream region. The P3 promoter, upstream of saeRS, generates the T3 transcript, includes a cis-acting enhancer element and is repressed by saeRS. The most distal P1 promoter is strongly autoregulated, activated by agr, and repressed by sigma factor B. In strain Newman a mutation within the histidine kinase SaeS leads to a constitutively activated sae system. Evaluation of different external signals revealed that the P1 promoter in strain ISP479R and strain UAMS-1 is inhibited by low pH and high NaCl concentrations but activated by hydrogen peroxide. The most prominent induction of P1 was observed at subinhibitory concentrations of α-defensins in various S. aureus strains, with the exception of strain ISP479R and strain COL. P1 was not activated by the antimicrobial peptides LL37 and daptomycin. In summary, the results indicate that the sensor molecule SaeS is activated by alteration within the membrane allowing the pathogen to react to phagocytosis related effector molecules.
Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior*

The biological underpinnings and the pathological lesions of psychiatric disorders are centuries-old questions that have yet to be understood. Recent studies suggest that schizophrenia and related disorders likely have their origins in perturbed neurodevelopment and can result from a large number of common genetic variants or multiple, individually rare genetic alterations. It is thus conceivable that key neurodevelopmental pathways underline the various genetic changes and the still unknown pathological lesions in schizophrenia. Here, we report that mice defective of the nicastrin subunit of γ-secretase in oligodendrocytes have hypomyelination in the central nervous system. These mice have altered dopamine signaling and display profound abnormal phenotypes reminiscent of schizophrenia. In addition, we identify an association of the nicastrin gene with a human schizophrenia cohort. These observations implicate γ-secretase and its mediated neurodevelopmental pathways in schizophrenia and provide support for the “myelination hypothesis” of the disease. Moreover, by showing that schizophrenia and obsessive-compulsive symptoms could be modeled in animals wherein a single genetic factor is altered, our work provides a biological basis that schizophrenia with obsessive-compulsive disorder is a distinct subtype of schizophrenia.