Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential survival gains in the treatment of myocardial infarction

Objectives: To evaluate the potential impact of complete implementation of guideline recommendations in myocardial infarction (MI) care, and contrast this with new innovations. Design: Modelling of potential events prevented from literature-based treatment effects and observed guideline recommendation utilisation rates. Setting: Hospital-based care. Participants: Nationwide registry of 1630 patients with MI adjusted for age, gender and GRACE score extrapolated to a population of 10 000 patients. Interventions: Literature-based efficacy estimates associated with guideline-recommended treatments and a putative treatment providing a 10–30% 12-month event reduction. Main outcome measures: Mortality and recurrent MI or stroke by 30 days and 30 days to 12 months. Results: Adjusted-mortality rates for optimally managed patients with ST-segment MI (STEMI) and non-ST-segment MI (NSTEMI) to 30 days were 0.6% and 2.5%, respectively. Adjusted mortality from 30 days to 12 months was 1.8% among optimally managed patients. No reperfusion occurred in 31% of patients with STEMI. Fewer than four guideline treatments were prescribed in 26% of patients at discharge. Compared with in-hospital care, better application of secondary prevention treatments provided the greater absolute gains (STEMI 23 lives/10 000 patients by 30 days, NSTEMI 43 lives/10 000 by 30 days and secondary prevention 104 lives/10 000 by 12 months). A putative novel treatment reducing mortality by 30% among optimally managed patients would save a further 4 lives/10 000 by 12 months. Conclusions: Potential gains from improved clinical effectiveness in MI care are likely to compare favourably with benefits achieved though innovations, and should inform priorities in research and implementation strategies for improving MI outcomes.
Creativity and Sustainable Tourism Development

The article justifies the need for targeted development of destination creativity as a sustainable tourism resource. The economic significance and the way this resource adds value to tourism is outlined. The role of creativity in tourism development is identified on the basis of the systematization of discussions existing in scientific literature and comparisons between creative and traditional forms of tourism. The specifics of tourism demand and supply of creative tourism experiences are consistently analyzed. Specific conclusions are made that could contribute to the sustainable development of tourism in Bulgaria based on the analysis carried out.
Research on Intelligent Home System based on Wireless Sensor Network

At present, the existing smart home subsystem uses different hardware and software and communication protocol. It has a single function and does not have a remote intelligent terminal and some of the traditional smart home system uses wired network set up, they have maintenance problems and poor system scalability. So it is difficult to form a true sense of the intelligent home system, it is difficult to achieve a unified remote monitoring and centralized monitoring. Smart home system based on wireless sensor network can make up the above shortcomings
Vaccines: An Innovative Approach to Treating Cancer

Recent scientific advances have expanded our understanding of the immune system and its response to malignant cells. Clinical trials are under way that attempt to translate this knowledge into effective cancer therapies. Vaccine therapy, an innovative approach to cancer treatment, attempts to activate the immune system to recognize cancer cells and eliminate them from the body. Preventive vaccines that already have been approved will have an impact on the incidence of certain cancers, and research is ongoing into treatment vaccines for various cancers.
The Failure Syndrome

Using the financial records of over 350 small businesses the authors attempt to identify symptoms that will forecast the failure of small businesses. These symptoms are grouped into three categories: (1) personal characteristics, (2) managerial deficiencies, and (3) financial shortcomings. The casual characteristics and incidence of the symptoms within each category are then analyzed. People possessing these symptoms are inflicted with what the authors call the “Failure Syndrome. ”
Transmembrane Signals and Intracellular “Second Messengers” in the Regulation of Quiescent B‐Lymphocyte Activation

The physiology of B lymphocytes is regulated by antigen, a large number of cellderived soluble molecules {cytokines) and perhaps by direct cell-cell contact. Historically, these species have been defined based upon their ability to modulate B-cell proliferative and antibody-forming cell responses. In retrospect, this is somewhat analogous to studying the effect of a dash of pepper on the ultitnate complexity of a bouillabaisse. Clearly the effects of many of these factors, while physiologically important, may not impinge, or may impinge too subtly, on cell proliferation or differentiation, to modify the B-cell response to tnitogens such as LPS. Recently, seveial laboralories have begun to focus their efforts on delineation of other, more rapid changes in lytnphocyte biology which follow ligand binding, such as IL-2 receptor expression. lL-2 secretion, increased Ia expression, and blastogenesis. as well as intervening cell physiologic events involved in coupling receptor occupancy to cell biologic responses. Studies of such parameters have revealed functional roles for some regulatory species which were not previously recognized. Unfortunately delineation of these new parameters has led to increasing confusion regarding the definition of lymphocyte "activation". For the purpose of this discussion, we will consider "activation" to be any change in lymphocyte physiology which could increase the cells" efficiency in mounting an imtnune response. Thus. IL-4 induction of Ia expression by quiescent B-cells will be considered activation because increased Ia expression appears to improve the ability of the B-cell to interact productively with helper T-cells.
Cellulose hydrolysis by the cellulases produced by Talaromyces emersonii when grown on different inducing substrates.

Pulp obtained from the processing of sugar beet at a local factory is mixed with molasses and sold as cattle food. However, the value of the pulp would be increased considerably if its constituent cellulose and hemicellulose fractions could be converted to fermentable sugars. To this end we are investigating the enzymic hydrolysis of beet pulp using the cellulase system produced by the thermophilic fungus, Talaromyces emersonii. In this Communication, we report on the initial results of studies. (Refs. 21).
FACTORS INFLUENCING ADOPTION OF FIBER OPTICS BY TELECOMMUNICATION COMPANIES IN KENYA

Purpose: The study sought to determine factors influencing adoption of fiber optics by telecommunication companies in Kenya Methodology: The study adopted a descriptive research. Results: Results indicated that majority of the respondents agreed that supplying commercial premises with fiber broadband will help businesses grow and benefit the local economy by facilitating flexible working patterns, enabling new startup businesses, and helping to improve the performance of existing businesses. Results indicated that cost was a key determinant in fibre optics adoption. Results indicated that majority of the respondents agreed that regulation reduces not only the investment incentives of regulated infrastructure operators but also those of potential entrant infrastructure operators who benefit from a risk-free option due to mandatory access obligations asymmetrically imposed on them, past regulation in first-generation broadband markets has clearly shaped the expectations for NGA regulations and pending decisions on NGA regulations have already led to substantial regulatory uncertainty, which constitutes another investment impediment. Results indicated security influenced adoption of fibre optics by telecommunication companies in Kenya. Finally, results also indicated that the respondents agreed that security technology providers need to prepare their technologies in order to address potential mandates for critical infrastructure protection of public cloud environments, computer viruses can proliferate through such a network and erase hard disks and intermediate files and cause system crashes and encryption, scanning files before downloading from the network, and anti-virus programs can alleviate most of the virus problem Unique contribution to theory, practice and policy: It was recommended in this study that the main telecom operators need to install more fiber optic cable not only in the urban areas but should also extend it to the rural areas to enable the whole Kenyan population to enjoy the benefits that accrue to its installation.
ER‐based double icre fusion protein allows partial recombination in forebrain

Here we describe the generation of a new tamoxifen‐inducible double Cre fusion protein generated by fusing two ERT2 domains onto both ends of the iCre recombinase (a codon improved Cre recombinase). This Cre fusion protein (ERiCreER) had a twofold increased activity in cell culture assays than the previously described MerCreMer Cre double fusion protein. ERiCreER was targeted to the brain by placing it under the control of the promoter from the CamKIIα gene using a 170 kb BAC. The fusion protein was detected in hippocampus, cortex, striatum, thalamus, and hypothalamus but not in cerebellum. The ERiCreER was cytoplasmatic in the absence of tamoxifen and translocated into the nucleus upon tamoxifen administration. The activity of the ERiCreER was tested in vivo by mating the CamKIIα ERiCreER transgenic line with mice harbouring exon 10 of the CREB gene flanked by two LoxP sites. In the absence of tamoxifen, no background activity was detected in mice older than 6 months. After tamoxifen administration, most if not all of the ERiCreER fusion protein translocated from the cytoplasm to the nucleus; however, only 5–10% of the “floxed” CREB allele was recombined. Recombination was also visualised at the cellular level by following the upregulation of the CREM protein, which corresponds precisely with CREB loss/recombination. Unlike in other tissues (Sohal et al., 2001; Tannour‐Louet et al., 2002), it appears that in brain, although ERiCreER can bind tamoxifen, the Cre‐recombinase cannot be fully activated. genesis 34:208–214, 2002. © 2002 Wiley‐Liss, Inc.
Pengaruh Karakteristik Perusahaan terhadap Pengungkapan Modal Intelektual dalam Prospektus Ipo

This study aims to empirically examine the effect of firm characteristics (industrial sector, firm age, retained ownership, firm size, and year when the firm went public) on intellectual capital information disclosure in IPO prospectuses. The study replicate previous research done by Alcaniz et al. (2015). The sample consists of 169 companies listed on Indonesia Stock that going public between 2007-2015. The extent of IC disclosure is collected and measured by using the IC disclosure index and framework proposed by Alcaniz et al. The mutiple regression analysis is used to examine the associations of five potential explanatory variables with intellectual capital disclosure level. The results provide evidence that industrial sector, firm size and year when the firm went public significantly influence IC disclosure in an IPO prospectus. The high-tech companies, larger companies, and those whose went public after 2009 provide more information about IC in IPO prospectuses. The other variables, age and retained ownership, were not significant.
LEADERSHIP STYLE, ORGANIZATIONAL COMMUNICATION, AND EMPLOYEE PARTICIPATION TO INCREASE EMPLOYEE READINESS IN FACING CHANGES IN BUSINESS ENVIRONMENT

The aim of this study is to analyze the influence of leadership style, organizational communication, and employee participation on employee readiness for changes in business environment at Small-Medium Enterprises (SMEs) in creative economy industrial sector, in partnership program of PT Pertamina (Persero) with criteria of having been established for at least 5 years, employing 20-99 personnels. Based on the criteria, only 3 SMEs meet the requirements; they are located in Bogor, Depok and Jakarta. This study involved 40 people, consisting of SME owners and employees. This study conducted descriptive analysis as well as Structural Equation Modeling PLS. The study resulted that both leadership style and organizational communication brought positive impact directly to employee participation, as well as positive impact indirectly to employee readiness for changes in business environment. In addition, employee participation also created direct positive influence to employee readiness for changes in business environment. The study results also suggest owners to actively communicate regarding planning for changes to improve employee participation. Nonetheless, both SME owners and PT Pertamina (Persero) shall continuously conduct relevant trainings.
The distribution of RNA polymerase in Escherichia coli is dynamic and sensitive to environmental cues

Despite extensive genetic, biochemical and structural studies on Escherichia coli RNA polymerase (RNAP), little is known about its location and distribution in response to environmental changes. To visualize the RNAP by fluorescence microscopy in E. coli under different physiological conditions, we constructed a functional rpoC–gfp gene fusion on the chromosome. We show that, although RNAP is located in the nucleoid and at its periphery, the distribution of RNAP is dynamic and dramatically influenced by cell growth conditions, nutrient starvation and overall transcription activity inside the cell. Moreover, mutational analysis suggests that the stable RNA synthesis plays an important role in nucleoid condensation.
Controversy and Consensus in Disaster Mental Health Research

Abstract Controversies regarding the mental health consequences of disasters are rooted both in disciplinary orientations and in the widely varied research strategies that have been employed in disaster mental health studies. However, despite a history of dissensus, there are also key issues on which researchers agree. Disasters constitute stressful and traumatic experiences. However, vulnerability to such experiences, as well as to more chronic Stressors, is socially structured, reflecting the influence of socio-economic status and other axes of stratification, including gender, race, and ethnicity. Disaster events differ in the extent to which they generate stress for victims. A holistic perspective on disaster mental health would take into account not only disaster event characteristics, but also social-systemic sources of both acute and chronic stress, secondary and cumulative Stressors, and victims internal and external coping capacities. Resumen Las controversias acerca de las consecuenciasen la salud mentalpor el impacto de los desastres, encuentran su origen en la orientación disciplinaria y en una ampliavariedad de estrategias empleadas en los estudios de salud mental en desastres. Sin embargo, a pesar de la historia de desacuerdos, hay varias cuestiones de importancia en las que los investigadores coinciden. Los desastres constituyen experiencias traumáticas. Sin embargo, la vulnerabilidad a dichas experiencias, así como a estresores más crónicos, se encuentran socialmente estructurados, reflejando la influencia del estatus socioeconómico y de otros ejes de estratificación, incluyendo sexo, edad, raza y cultura. Los desastres difieren en la extensión del estrés que provocan en las víctimas. Una perspectiva holtística de la salud mental en los desastres, debe considerar no solo las características del evento, sino también el origen sistémico-social del estrés agudo y crónico, así como los estresores secundarios y acumulativos, además de las capacidades de manejo internas y externas de las víctimas.
Transformerless DC-DC converter with high voltage gain based on a switched-inductor structure applied to photovoltaic systems

In photovoltaic (PV) systems, high step-up dc-dc converters are required to manage the power flow. Since the output voltage of photovoltaic source is lower than the grid voltage level, dc-dc converters with high voltage gain are the solution in transformerless topologies. A high step-up dc-dc Ćuk converter with switched-inductor is proposed in this paper. The presented topology is designed to application in current source inverters (CSI) and unfolding inverters. Furthermore, to validate theoretical analysis, a 200W prototype is implemented. Lastly, a dc rectified sinusoidal output current modulation is performed to validate its application in unfolding inverters.
Initial Returns, Long Run Performance and Characteristics of Issuers: Differences in Indian IPOs Following Fixed Price and Book building Processes

Initial returns (or underpricing) and long run performance of IPOs have been researched extensively across countries. Recent research on IPOs has also been focused on differences in pricing and allocation mechanisms across countries. Indian IPO markets provide a natural setting for comparing the characteristics of issuers, initial returns and long run performance of IPOs coming out with fixed price versus book building route. On a sample of 84 Indian IPOs (20 book-build and 64 fixed-price) from the period 1999 to 2002, we find that the fixed price offerings are used by issuers offering large proportion of their capital by raising a small amount of money. In contrast, book building is opted for by issuers offering small proportion of their stocks and mobilizing larger sums of money. Unlike in the early nineties, the activity in Indian IPO markets is now increasingly following trend of “industry-specific waves” of IPOs as most of the IPOs in our sample are from sectors, which were “hot” during the period. Consistent with the evidence from other countries, initial returns are higher and more uncertain on fixed price offerings. Again in line with evidence elsewhere, all types of Indian IPOs in our sample under performed in the first two years subsequent to listing. We also find some evidence that the IPOs from issuers belonging to industries under the spell of “hot issue” market, under perform more than the rest.
A review of recent trends and challenges in 3 D printing

The recent developments in 3D printing also known as “Additive Manufacturing” or AM have revolutionized the modern manufacturing process and the engineering design process. Emerging use of 3D printing technology is prevalent in automotive, manufacturing, aerospace, pharmaceutical industry & healthcare, fashion, retail and sports. In this paper, the author propose to review the recent trends and challenges in 3D printing technology. The technological advancements in extrusion materials, design & processes, equipment's capability have brought down the cost of manufacturing. The proposed paper will review latest developments in 3D printing material types, manufacturing techniques, equipment types, and the development of standards for selecting material, quality control, and 3D printing machinery. World demand for 3D printers and related materials and software is projected to rise 21 percent per year to $5.0 billion in 2017 per freedoniagroup. It is about time to educate the future designers, engineers and entrepreneurs on 3D printing. A typical course curriculum is also proposed to add an elective course in the mechanical engineering department in one of the Michigan regional universities.
Effects of ozone on lung function and lung diseases

Ozone (O3) is an air pollutant produced by sunlight-driven reactions involving the oxides of nitrogen and volatile organic compounds. The population of many large metropolitan areas in the US is exposed to high levels of O3, particularly in the summer months. Individuals exposed to O3 levels in human experiments at higher than common ambient levels develop reversible reductions in lung function often associated with symptoms, such as airway hyperreactivity and lung inflammation. Animal models have helped characterize potential mechanisms of lung injury from O3 exposure. Defining the adverse effects of chronic exposure to ambient levels of O3 on lung function and disease have been challenging, in part due to the presence of co-pollutants, such as particulate matter. The US Environmental Protection Agency's 1997 revised standard for O3 (0.08 ppm averaged over 8 hours) is designed to provide better protection to susceptible individuals. The revised standard is being implemented following the failure of court challenges.
Huangqi injection in the treatment of chronic heart failure

Background: To evaluate the clinical effectiveness and safety of Huangqi injection (HI) in treating chronic heart failure (CHF) systematically. Methods: A literature search was conducted for retrieving randomized controlled trials (RCTs) on CHF treated by HI in the Cochrane Library, PubMed, Embase, China Biology Medicine disc, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database up to June, 6, 2017, and then the included RCTs were assessed by the Cochrane Risk of Bias Assessment Tool. The clinical total effective rate, left ventricular ejection fraction (LVEF), and others outcomes were analyzed by Review Manager 5.3 in random-effect model, the funnel plot were depicted as well. Meanwhile, the sensitivity analysis was carried out by STATA 12.0. Results: Sixteen RCTs involved 1864 patients were included. The result of HI group was more efficient in the clinical total effective rate (RR = 1.19, 95% confidence intervals (95% CI) [1.14–1.26], P < . 00001). In addition, HI plus western medicine (WM) could improve LVEF (MD = 4.64, 95% CI [3.52–5.75], P < .00001), and others cardiac indexes. Meanwhile, a combination of HI and WM also can perfect 6 minutes walk test (6MWT). Three RCTs reported no serious adverse drug events/adverse drug reactions occurred. Conclusion: Compared with WM, a combination of HI and WM was more efficacious in improving the clinical total effective rate, and perfect patients’ condition, but more evidence-based medicine researches needed to support this study further.
Molecular Basis for Increased Susceptibility of Isolates with Atazanavir Resistance-Conferring Substitution I50L to Other Protease Inhibitors

ABSTRACT Protease inhibitors (PIs) are highly effective drugs against the human immunodeficiency virus (HIV), yet long-term therapeutic use is limited by emergence of HIV type 1 (HIV-1) protease substitutions that confer cross-resistance to multiple protease inhibitor drugs. Atazanavir is a highly potent HIV protease inhibitor with a distinct resistance profile that includes effectiveness against most HIV-1 isolates resistant to one or two PIs. The signature resistance substitution for atazanavir is I50L, and it is frequently (53%) accompanied by a compensatory A71V substitution that helps restore viability and increases atazanavir resistance levels. We measured the binding affinities of wild-type (WT) and I50L/A71V HIV-1 proteases to atazanavir and other currently approved PIs (ritonavir, lopinavir, saquinavir, nelfinavir, indinavir, and amprenavir) by isothermal titration calorimetry. Remarkably, we find that all of the PIs have 2- to 10-fold increased affinities for I50L/A71V protease, except for atazanavir. The results are also manifested by thermal stability measures of affinity for WT and I50L/A71V proteases. Additional biophysical and enzyme kinetics experiments show I50L/A71V protease is a stable enzyme with catalytic activity that is slightly reduced (34%) relative to the WT. Computational modeling reveals that the unique resistance phenotype of I50L/A71V protease likely originates from bulky tert-butyl groups at P2 and P2′ (specific to atazanavir) that sterically clash with methyl groups on residue L50. The results of this study provide a molecular understanding of the novel hypersusceptibility of atazanavir-resistant I50L/A71V-containing clinical isolates to other currently approved PIs.