Miracle-dz/UniFAR-FTUs huggingface dataset:
Synthesis of NiO Nanostructures by Sonocatalyzed Microwave Irradiation Technique and Their Acetone Sensing Properties

Abstract Nickel oxide (NiO) nanostructures were synthesized by sonocatalyzed microwave irradiation technique, followed by calcination process. Electron microscopic images of NiO powder calcined at 500 °C revealed coexistence of nanorods and spherical nanoparticles. The NiO powders calcined at 600 and 700 °C composed of spherical nanoparticles, where a larger particle size was observed for the powder calcined at 700 °C. The acetone sensor response of the fabricated NiO sensors revealed that shape and size of the NiO particles affected the response. The response increased with increasing acetone gas concentration, which reached a maximum value at the operating temperature of 325 °C.
Re-reading the OECD and education: the emergence of a global governing complex – an introduction

ABSTRACT This article introduces the Special Issue ‘Re-reading the OECD and education: the emergence of a global governing complex’. Its distinctive contribution is related to its dual epistemological aims: to explore how different conceptual lenses and methodological approaches add to our understanding of the OECD as an intergovernmental organisation; and second, to understand the ways in which the strategic activities and priorities of the OECD have been constructed, historically and contemporarily, and the implications in terms of governance and education on a global scale. Broadly, this dual dynamic – of ‘seeing the OECD’ and ‘seeing like the OECD’ – has generated the papers included in this Special Issue. Our Introduction outlines the specific foci and contributions of these papers with reference to four thematic lines of analysis in the research literature: (i) the changing capacities and positions of the OECD in global governance; (ii) the main ideas and styles of reasoning underpinning OECD governance; (iii) the formal and informal processes and workings of OECD’s policy formation; and (iv) the impact and wider implications of the OECD in education policy and practice.
On the numerical simulation of Time-Space fractional coupled nonlinear SchröDinger equations utilizing Wendland's compactly Supported function collocation method

This research describes an efficient numerical method based on Wendland’s compactly supported functions to simulate the time-space fractional coupled nonlinear Schrödinger (TSFCNLS) equations. Here, the time and space fractional derivatives are considered in terms of Caputo and Conformable derivatives, respectively. The present numerical discussion is based on the following ways: we first approximate the Caputo fractional derivative of the proposed equation by a scheme order O(∆t2−α), 0 < α < 1 and then the Crank-Nicolson scheme is employed in the mentioned equation to discretize the equations. Second, applying a linear difference scheme to avoid solving nonlinear systems. In this way, we have a linear, suitable calculation scheme. Then, the conformable fractional derivatives of the Wendland’s compactly supported functions are established for the scheme. The stability analysis of the suggested scheme is also examined in a similar way to the classic Von-Neumann technique for the governing equations. The efficiency and accuracy of the present method are verified by solving two examples.
The State of the Art in Methodologies of Course Recommender Systems - A Review of Recent Research

In recent years, education institutions have offered a wide range of course selections with overlaps. This presents significant challenges to students in selecting successful courses that match their current knowledge and personal goals. Although many studies have been conducted on Recommender Systems (RS), a review of methodologies used in course RS is still insufficiently explored. To fill this literature gap, this paper presents the state of the art of methodologies used in course RS along with the summary of the types of data sources used to evaluate these techniques. This review aims to recognize emerging trends in course RS techniques in recent research literature to deliver insights for researchers for further investigation. We provide a systematic review process followed by research findings on the current methodologies implemented in different course RS in selected research journals such as: collaborative, content-based, knowledge-based, Data Mining (DM), hybrid, statistical and Conversational RS (CRS). This study analyzed publications between 2016 and June 2020, in three repositories; IEEE Xplore, ACM, and Google Scholar. These papers were explored and classified based on the methodology used in recommending courses. This review has revealed that there is a growing popularity in hybrid course RS and followed by DM techniques in recent publications. However, few CRS-based course RS were present in the selected publications. Finally, we discussed future avenues based on the research outcome, which might lead to next-generation course RS.
Addressing Parental Vaccine Hesitancy and Other Barriers to Childhood/Adolescent Vaccination Uptake During the Coronavirus (COVID-19) Pandemic

Routine childhood immunizations are proven to be one of the most effective public health interventions at controlling numerous deadly diseases. Therefore, the CDC recommends routine immunizations for children and adolescent populations against vaccine-preventable diseases e.g., tetanus, pertussis, diphtheria, etc. This current review sought to examine barriers to pediatric vaccine uptake behaviors during the COVID-19 pandemic. We also explored the implications for parental vaccine hesitancy/delay during an ongoing health crisis and proposed recommendations for increasing vaccine confidence and compliance. Our review determined that the receipt for vaccinations steadily improved in the last decade for both the United States and Tennessee. However, this incremental progress has been forestalled by the COVID-19 pandemic and other barriers i.e. parental vaccine hesitancy, social determinants of health (SDoH) inequalities, etc. which further exacerbate vaccination disparities. Moreover, non-compliance to routine vaccinations could cause an outbreak of diseases, thereby, worsening the ongoing health crisis and already strained health care system. Healthcare providers are uniquely positioned to offer effective recommendations with presumptive languaging to increase vaccination rates, as well as, address parental vaccine hesitancy. Best practices that incorporate healthcare providers’ quality improvement coaching, vaccination reminder recall systems, adherence to standardized safety protocols (physical distancing, hand hygiene practices, etc.), as well as, offer telehealth and outdoor/drive-through/curbside vaccination services, etc. are warranted. Additionally, a concerted effort should be made to utilize public health surveillance systems to collect, analyze, and interpret data, thereby, ensuring the dissemination of timely, accurate health information for effective health policy decision-making e.g., vaccine distribution, etc.
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory

Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the telencephalon. However, the nucleus incertus (NI) of the pontine tegmentum provides a strong GABAergic and peptidergic innervation of the hippocampus, basal forebrain, amygdala, prefrontal cortex, and related regions; and represents a parallel source of ascending modulation of cognitive and emotional domains. NI GABAergic neurons express multiple peptides, including neuromedin-B, cholecystokinin, and relaxin-3, and receptors for stress and arousal transmitters, including corticotrophin-releasing factor and orexins/hypocretins. A functional relationship exists between NI neurons and their associated peptides, relaxin-3 and neuromedin-B, and hippocampal theta rhythm, which in turn, has a key role in the acquisition and extinction of declarative and emotional memories. Furthermore, RXFP3, the cognate receptor for relaxin-3, is a Gi/o protein-coupled receptor, and its activation inhibits the cellular accumulation of cAMP and induces phosphorylation of ERK, processes associated with memory formation in the hippocampus and amygdala. Therefore, this review summarizes the role of NI transmitter systems in relaying stress- and arousal-related signals to the higher neural circuits and processes associated with memory formation and retrieval.
Conceptualising Primary-Secondary School Transitions: A Systematic Mapping Review of Worldviews, Theories and Frameworks

There is continued interest internationally in primary-secondary school transitions. Fourteen literature reviews of primary-secondary transitions have been published over the last 20 years, however none of them have systematically analysed primary-secondary school transition ontology, i.e., researchers’ worldviews, theories/models and frameworks. This is a major gap in these reviews and the papers published in this area; this is of concern as it is difficult to trust the robustness of a study if its foundation, such as researchers’ conceptualisation of transitions, is not visible. Therefore, using the Evidence for Policy and Practice Information and Co-ordinating Centre (EPPI-Centre) approach, we undertook a systematic mapping review, of empirical studies published internationally between 2008 and 2018. Our objectives were to explore researchers’ and research participants’ conceptualisation of transitions, the conceptual framework used by the researchers and their discourse about transitions. Of the 96 studies included in this systematic mapping review, most had not clearly defined transition, and even when conceptualisation was explicit, it did not underline the research design or frame the findings. Most researchers adopted previously used theoretical frameworks.These theoretical frameworks can be beneficial; however, as the researchers did not adapt or develop them in the context of transitions research, it limits a meta-theoretical understanding of transitions. Further, the majority did not report study participants’conceptualisation of transitions. Similarly, a large number of researchers adopted a negative discourse about primary-secondary school transitions, with some using a mixed discourse and only two papers had a primarily positive discourse. This systematic mapping review is original and significant as it is the first study to provide a review of school transitions ontology and offers unique insights into the conceptual and methodological gaps that international transitions researchers should address.
Silencing of the TRIM58 Gene by Aberrant Promoter Methylation is Associated with a Poor Patient Outcome and Promotes Cell Proliferation and Migration in Clear Cell Renal Cell Carcinoma

To investigate the underlying molecular mechanism of tripartite motif-containing 58 (TRIM58) in the development of clear cell renal cell carcinoma (ccRCC), we explored TRIM58 expression and methylation in tumor tissues and the association with clinicopathological features and prognosis of tissue samples; Moreover, we examined the direct gene transcription of TRIM58-specific DNA demethyltransferase (TRIM58-TET1) by the CRISPR-dCas9 fused with the catalytic domain of TET1 and the biological functions in RCC cells. In this study, we demonstrate that TRIM58 is frequently downregulated by promoter methylation in ccRCC tissues, associated significantly with tumor nuclear grade and poor patient survival. TRIM58-TET1 directly induces demethylation of TRIM58 CpG islands, and activates TRIM58 transcription in RCC cell lines. Besides, DNA demethylation of TRIM58 by TRIM58-TET1 significantly inhibits cell proliferation and migration Overall, our results demonstrate that TRIM58 is inactivated by promoter methylation, associates with tumor nuclear grade and poor survival, and TRIM58 DNA demethylation could directly activate TRIM58 transcription and inhibit cell proliferation and migration in RCC cell lines.
Invasion Success of Bunias orientalis (Warty Cabbage) in Grasslands: A Mesocosm Experiment on the Role of Hydrological Stress and Disturbance

Climate change is altering precipitation patterns, with higher frequency and magnitude of extreme events. Specifically, longer and more pronounced waterlogged conditions are predicted after rain spells as well as more frequent droughts, especially in Central Europe. Such hydrological changes can severely affect species performance and alter the function of ecosystems, as well as favor plant invasions. Competition with native communities may change depending on water stress. Bunias orientalis is an invasive plant that may benefit from disturbance or precipitation changes. We conducted a 3-year mesocosm experiment in a common garden to investigate how invasion success of B. orientalis in native German grassland communities is affected by varying hydrological conditions (from very dry to waterlogged). We measured the establishment and growth of B. orientalis in varying water table depths in bare soil (simulating disturbance) vs. in the community. Establishment and biomass of B. orientalis was generally highest under non-stress conditions. The species was also highly tolerant to dry conditions, but only when growing in bare soil. However, performance of B. orientalis was generally low, whereby interspecific competition in communities greatly limited invasion success. This might be due to the low competitive ability of the species in conditions of hydrological stress and the near-natural grassland communities with an extensive mowing regime used in our experiment. Our results suggest that invasion success of B. orientalis in grasslands will not increase if precipitation patterns change toward more extreme events. However, disturbance that creates bare soil patches might favor B. orientalis under drought conditions.
Adverse Childhood Experiences and Early Maladaptive Schemas as Predictors of Cyber Dating Abuse: An Actor-Partner Interdependence Mediation Model Approach

The increasing role that new technologies play in intimate relationships has led to the emergence of a new form of couple violence, cyber dating abuse, especially among adolescents and young adults. Although this phenomenon has received increased attention, no research has investigated predictors of cyber dating abuse taking into account the interdependence of the two partners. The study examines adverse childhood experiences (abuse, neglect, and witnessed intimate partner violence) and early maladaptive schemas (emotional deprivation and abandonment) as possible predictors of young adults’ perpetrated and suffered cyber dating abuse. Adopting a dyadic approach, mediational models in which adverse childhood experiences were assumed to be related to individual and partner’s cyber dating abuse through individual early maladaptive schemas were tested. 134 couples completed online self-reports of the variables of interest, including a bidimensional measure of cyber dating abuse assessing pressure-aggression and control-monitoring. Actor-partner interdependence mediation model analyses were conducted. Results indicated that the emotional deprivation schema mediated the association between adverse childhood experiences and cyber dating abuse, whereas the abandonment schema did not. Specifically, more frequent experiences of emotional abuse and physical neglect during childhood were indirectly related to increased likelihood of perpetrating cyber dating pressure-aggression as well as of perpetrating and suffering cyber dating control-monitoring in both males and females. These associations were mediated by a stronger internalization of the emotional deprivation schema and were supported by both self-reported and partner-reported data. Also, a strong and direct association was found between childhood exposure to intimate partner violence by the opposite-sex parent and cyber dating pressure-aggression by females or control-monitoring by both males and females. These findings help to clarify the potential negative effects of specific adverse childhood experiences and early maladaptive schemas on the tendency to perpetrate and suffer cyber abuse in romantic relationships. The implications for prevention and treatment programs are noted and avenues for future research are described.
The Limitless Future of RNA Therapeutics

Recent advances in the generation, purification and cellular delivery of RNA have enabled development of RNA-based therapeutics for a broad array of applications. RNA therapeutics comprise a rapidly expanding category of drugs that will change the standard of care for many diseases and actualize personalized medicine. These drugs are cost effective, relatively simple to manufacture, and can target previously undruggable pathways. It is a disruptive therapeutic technology, as small biotech startups, as well as academic groups, can rapidly develop new and personalized RNA constructs. In this review we discuss general concepts of different classes of RNA-based therapeutics, including antisense oligonucleotides, aptamers, small interfering RNAs, microRNAs, and messenger RNA. Furthermore, we provide an overview of the RNA-based therapies that are currently being evaluated in clinical trials or have already received regulatory approval. The challenges and advantages associated with use of RNA-based drugs are also discussed along with various approaches for RNA delivery. In addition, we introduce a new concept of hospital-based RNA therapeutics and share our experience with establishing such a platform at Houston Methodist Hospital.
PLAU1 Facilitated Proliferation, Invasion, and Metastasis via Interaction With MMP1 in Head and Neck Squamous Carcinoma

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant neoplasm; it is associated with high morbidity and mortality. Thus, understanding the molecular mechanisms underlying its initiation and progression is critical for establishing the most appropriate treatment strategies. We found that urokinase-type plasminogen activator (PLAU1) was upregulated and associated with poor prognosis in HNSCC. Silencing of PLAU1 inhibited the proliferation, colony-formation, migration, and invasion abilities of HNSCC cells in vitro and reduced the expression of matrix metalloproteinase 1 (MMP1), whereas PLAU1 overexpression significantly enhanced the growth, the colony-formation, migration, and invasion abilities, and the xenograft tumor growth of HNSCC cells in vivo and increased the expression of MMP1. The Co-IP assay verified that PLAU1 interacted with MMP1. A positive correlation between PLAU1 and MMP1 expression was observed in HNSCC samples. si-RNAs against MMP1 reversed the aggressive effects of PLAU1 overexpression in HNSCC. Taken together, our data revealed that PLAU1 facilitated HNSCC cell proliferation, invasion, and metastasis via interaction with MMP1.
Impact of Early Life Nutrition on Children’s Immune System and Noncommunicable Diseases Through Its Effects on the Bacterial Microbiome, Virome and Mycobiome

The first 1000 days of life, including the intrauterine period, are regarded as a fundamental stepping stone for the development of a human. Unequivocally, nutrition during this period plays a key role on the proper development of a child, both directly through the intake of essential nutrients and indirectly by affecting the composition of the gut microbiota. The gut microbiota, including bacteria, viruses, fungi, protists and other microorganisms, is a highly modifiable and adaptive system that is influenced by diet, lifestyle, medicinal products and the environment. Reversely, it affects the immune system in multiple complex ways. Many noncommunicable diseases (NCDs) associated with dysbiosis are “programmed” during childhood. Nutrition is a potent determinant of the children’s microbiota composition and maturation and, therefore, a strong determinant of the NCDs’ programming. In this review we explore the interplay between nutrition during the first 1000 days of life, the gut microbiota, virome and mycobiome composition and the development of NCDs.
Consuming Costly Prey: Optimal Foraging and the Role of Compensatory Growth

Some prey are exceptionally difficult to digest, and yet even non-specialized animals may consume them—why? Durophagy, the consumption of hard-shelled prey, is thought to require special adaptations for crushing or digesting the hard shells to avoid the many potential costs of this prey type. But many animals lacking specializations nevertheless include hard-bodied prey in their diets. We describe several non-mutually exclusive adaptive mechanisms that could explain such a pattern, and point to optimal foraging and compensatory growth as potentially having widespread importance in explaining costly-prey consumption. We first conducted a literature survey to quantify the regularity with which non-specialized teleost fishes consume hard-shelled prey: stomach-content data from 325 teleost fish species spanning 82 families (57,233 stomach samples) demonstrated that non-specialized species comprise ~75% of the total species exhibiting durophagy, commonly consuming hard-shelled prey at low to moderate levels (~10–40% as much as specialists). We then performed a diet survey to assess the frequency of molluscivory across the native latitudinal range of a small livebearing fish, Gambusia holbrooki, lacking durophagy specializations. Molluscivory was regionally widespread, spanning their entire native latitudinal range (>14° latitude). Third, we tested for a higher frequency of molluscivory under conditions of higher intraspecific resource competition in Bahamian mosquitofish (Gambusia spp.). Examining over 5,300 individuals, we found that molluscivory was more common in populations with higher population density, suggesting that food limitation is important in eliciting molluscivory. Finally, we experimentally tested in G. holbrooki whether molluscivory reduces growth rate and whether compensatory growth follows a period of molluscivory. We found that consumption of hard-shelled gastropods results in significantly reduced growth rate, but compensatory growth following prior snail consumption can quickly mitigate growth costs. Our results suggest that the widespread phenomenon of costly-prey consumption may be partially explained by its relative benefits when few alternative prey options exist, combined with compensatory growth that alleviates temporary costs.