Miracle-dz/UniFAR-FTUs huggingface dataset:
Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence

Adherence to the medical regimen continues to rank as a major clinical problem in the management of patients with essential hypertension, as in other conditions treated with drugs and life-style modification. This article reviews the psychometric properties and tests the concurrent and predictive validity of a structured four-item self-reported adherence measure (alpha reliability = 0.61), which can be easily integrated into the medical visit. Items in the scale address barriers to medication-taking and permit the health care provider to reinforce positive adherence behaviors. Data on patient adherence to the medical regimen were collected at the end of a formalized 18-month educational program. Blood pressure measurements were recorded throughout a 3-year follow-up period. Results showed the scale to demonstrate both concurrent and predictive validity with regard to blood pressure control at 2 years and 5 years, respectively. Seventy-five percent of the patients who scored high on the four-item scale at year 2 had their blood pressure under adequate control at year 5, compared with 47% under control at year 5 for those patients scoring low (P < 0.01).
Inhibition by baclofen of NMDA-activated current in rat dorsal root ganglion neurons.

AIM To explore the modulatory effect of baclofen on NMDA-activated current in rat dorsal root ganglion (DRG) neurons. METHODS Whole-cell patch-clamp technique was used to record NMDA-activated current in isolated DRG neurons. Drugs were applied by rapid solution exchange. RESULTS Preapplication of baclofen 1-100 mumol.L-1 induced a concentration-dependent inhibition of the inward NMDA-activated current markedly. NMDA (100 mumol.L-1)-activated current was inhibited by 52% +/- 14% (n = 11, P < 0.01) by preapplication of baclofen 100 mumol.L-1. The inhibitory effect of baclofen was reversible, and was removed by saclofen 100 mumol.L-1, which was a selective antagonist of GABAB receptor. CONCLUSION Preapplication of baclofen exerts an inhibitory effect on NMDA-activated current in the primary sensory neurons.
Target Tracking using Signal Strength Differences for Long-Range IoT Networks

Radio based positioning or tracking solutions typically require wideband signals or phase coherent antennas. In this paper, we present a target tracking method based on received non-coherent signal strength differences (RSSDs) between antennas for outdoor Internet-of-things (IoT) scenarios. We introduce an RSSD model based on classical path-loss models. With known antenna patterns and antenna array geometries, the RSSD model enables direct mapping between RSSD and angle of arrival, without involving parameters like transmit power, path-loss coefficient, etc. The RSSD model is then exploited in a recursive Bayesian filtering method for target tracking where a particle filter-based implementation is used. The performance is evaluated using outdoor measurements in a low-power wide area network (LoRaWAN) based IoT system. Besides, we also investigate the potential of the RSSD model for AoA estimation. The experimental results show the capability of the proposed framework for real-time target/AoA tracking; reasonable accuracy is achieved even when using non-averaged RSS measurements and under non line-of-sight (NLoS) conditions. Furthermore, the non-coherent approach has low computational complexity, scales well, and is flexible to allow for different antenna array configurations.
Tranylcypromine: A review

In the six years since it was added to the antidepressant agents, tranylcypromine has attracted wide attention because of toxic side reactions and disputed efficacy. It was the first clinically important nonhydrazine monoamine oxidase inhibitor, and it remains Widely used. This review attempts fully to present the history, pharmacology, clinical toxicology, and evidence for the degree of clinical value of the drug in the treatment of depression. The hypertensive syndrome most notable among the drug's adverse reactions probably occurs very infrequently but is largely an unpredictable phenomenon. Fifty‐four of the fifty‐six published clinical trials have been assessed. Many were uncontrolled, encumbered by other concurrent treatments and heterogeneous patient samples, or inadequately reported. Assessment of trials indicated that the drug alone was beneficial in reactive and psychoneurotic depressions, while it tended not to influence agitated, psychotic, or endogenous depressions. Where the drug was compared to other treatments for depreSsion, it was found equivalent or superior to other monoamine oxidase inhibitors in several trials, while it was generally inferior to iminodibenzyl compounds and to electroshock treatment. The findings support a view that tranylcypromine is not the treatment of choice for depression but that it may be indicated where other drugs or ECT have failed.
Methylseleninic acid inhibits microvascular endothelial G1 cell cycle progression and decreases tumor microvessel density

Our previous work has shown that the cancer chemopreventive effect of selenium may in part be mediated by its antiangiogenic activities and that methylseleninic acid (MSeA) can induce G1 arrest of human umbilical vein endothelial (macrovascular) cells. The objectives of the current study are to verify MSeA‐induced G1 arrest effect in microvascular endothelial cells and to elucidate the molecular mediators and targets involved. Flow cytometric analysis after MSeA exposure (2–10 μM) of telomerase‐immortalized microvascular endothelial (TIME) cells for 24 hr showed aconcentration‐dependent increase of G1‐arrested cells. MSeA (3 μM) treatment delayed the mitogen‐stimulated progression of TIME cells from G1 to S phase. These effects of MSeA were accompanied by an early transient (6 hr) upregulation of P21/CIP1 and P27/KIP1 and a delayed modest increase of P16/INK4a (12 hr). MSeA increased P27/KIP1 mRNA transcript level and slowed the turnover of P21/CIP1 protein. MSeA‐treated cells contained elevated levels of bound P16/INK4a within the CDK4/6/cyclin D1 complexes as well as bound P21/CIP1 and P27/KIP1 within the CDK2/cyclin E complex and decreased their kinase activities. MSeA suppressed the mitogen/CDK‐driven phosphorylative inactivation of retinoblastoma (Rb) protein, diminishing E2F1 release from Rb. In vivo, daily oral MSeA treatment of nude mice bearing subcutaneously inoculated human prostate cancer DU145 xenografts inhibited tumor growth in a dose‐dependent manner. The microvessel density of the tumors in the high MSeA group was decreased by more than half from the control. An inhibition of mitogen‐stimulated proliferation of endothelial cells by MSeA may therefore contribute to the inhibition of tumor angiogenesis. © 2007 Wiley‐Liss, Inc.
Parents' education, cognitive ability, educational expectations and educational attainment: interactive effects.

BACKGROUND The models that have been used so far to describe the process underlying educational attainment have been almost always linear. Little research has been aimed at studying interactions among the determinants of educational attainment. AIM The aim of the study is to examine the interactions between parents' education, cognitive ability and educational expectations in determining educational attainment. SAMPLE Participants were 8570 Americans who were born between 1957 and 1964. METHOD The information was taken from the National Longitudinal Survey of Youth. Information about parents' education, cognitive ability and educational expectations was taken from the 1979 survey. Information about educational attainment was taken from the 1991 survey. RESULTS The findings indicate that there is an offsetting relationship between the education of the two parents in the formation of expectations, but not in the determination of attainment; and that, both for expectations and for attainment, the cognitive ability of the child has an offsetting relationship with mother's education but not with father's education. The findings also indicate that there is a synergistic relationship between cognitive ability and educational expectations in determining educational attainment. CONCLUSIONS There are theoretically meaningful interactions between the determinants of educational attainment. The pattern of these interactions capture some of the intricate psychological processes underlying the combined influence of background variables and children's characteristics on educational attainment.
Comments/Responses Poor Dental Health and Dementia

gression and lack of fluctuation of symptoms, which resulted from a variation in clinical progression of HE and difficulties in detecting fluctuation within low-stage HE. Acute onset and fluctuation of symptoms are considered essential features of delirium, but the possibility of delirium should not be excluded if any one of the core features exists. The present case also indicates that maintaining appropriate lavatory conditions at emergency shelters is important not only for preventing infections, but also for maintaining good excretory habits.
Optimization Based Sliding Mode Control in Active Suspensions: Design and Hardware-in-the-Loop Assessment

The paper presents an optimization based sliding mode controller designed to provide the correct amount of force to the actuator of an active suspension system in order to guarantee ride comfort. First, the description of the mechanics of the active suspension system is provided. Then, the mathematical state space form of the quarter-car active suspension model is introduced. A Sliding Mode Control controller is designed to properly manage the active force production. The parameters of the proposed controller are tuned, relying on an optimization procedure, so as to improve the quality of the ride, in particular in terms of ride comfort, road holding and suspension deflection. First, the performance of the controlled active suspension are assessed in simulation using the formulated quarter-car mode. Then, the proposed optimized sliding mode controller is tested on an experimentally validated full-car model of a Range Rover Evoque in a Hardware-in-the-Loop (HiL) test rig available at the Automotive Engineering Department of TU Ilmenau, also comparing its performance with those obtained by using a standard PID controller. The HiL test rig is equipped with an active electromechanical suspension system. Simulation and HiL test results confirm that the proposed SMC controller provides better ride quality than the standard PID controller, which corroborates its suitableness for practical implementation.
Efficacy and safety of TMC278 in antiretroviral-naive HIV-1 patients: week 96 results of a phase IIb randomized trial

Objective:TMC278 is a next-generation nonnucleoside reverse transcriptase inhibitor highly active against wild-type and nonnucleoside reverse transcriptase inhibitor-resistant HIV-1 in vitro. The week 96 analysis of TMC278-C204, a large dose-ranging study of TMC278 in treatment-naive HIV-1-infected patients, is presented. Design:Phase IIb randomized trial. Methods:Three hundred sixty-eight patients were randomized and treated with three blinded once-daily TMC278 doses 25, 75 or 150 mg, or an open-label, active control, efavirenz 600 mg once daily, all with two nucleoside reverse transcriptase inhibitors. The primary analysis was at week 48. Results:No TMC278 dose–response relationship for efficacy and safety was observed. TMC278 demonstrated potent antiviral efficacy comparable with efavirenz over 48 weeks that was sustained to week 96 (76.9–80.0% and 71.4–76.3% of TMC278-treated patients with confirmed viral load <50 copies/ml, respectively; time-to-loss of virological-response algorithm). Median increases from baseline in CD4 cell count with TMC278 at week 96 (138.0–149.0 cells/μl) were higher than at week 48 (108.0–123.0 cells/μl). All TMC278 doses were well tolerated. The incidences of the most commonly reported grade 2–4 adverse events at least possibly related to study medication, including nausea, dizziness, abnormal dreams/nightmare, dyspepsia, asthenia, rash, somnolence and vertigo, were low and lower with TMC278 than with efavirenz. Incidences of serious adverse events, grade 3 or 4 adverse events and discontinuations due to adverse events were similar among groups. Conclusion:All TMC278 doses demonstrated potent and sustained efficacy comparable with efavirenz in treatment-naive patients over 96 weeks. TMC278 was well tolerated with lower incidences of neurological and psychiatric adverse events, rash and lower lipid elevations than those with efavirenz. TMC278 25 mg once daily was selected for further clinical development.
A Cross-Sectional Survey of Nonspecific Low Back Pain Among 2083 Schoolchildren in China

Study Design. A cross-sectional survey of 2083 schoolchildren. Objective. To investigate the prevalence of nonspecific low back pain (LBP) among schoolchildren aged between 10 and 18 years in China. Summary of Background Data. LBP have been a serious health problem in schoolchildren. On the basis of literature, the lifetime occurrence of nonspecific LBP in children and adolescents varies between 7% and 72%, but little is known about LBP among this demographic group in China. Methods. Schoolchildren aged 10 to 18 years were sampled from two grades in an elementary school and four grades in a secondary school. Participants were asked to fill in a questionnaire on LBP. The questionnaire addressed demographic items, anthropometric factors and characteristics of nonspecific LBP, such as frequency, duration, nature, pain scale. Nonspecific LBP is defined as the pain in the back from the 12th ribs to the buttock area without organic factors. A total of 2235 questionnaires were distributed, of which 2100 were answered, a response rate of 93.7%. Among those answers, 2083 (977 from male students and 1106 from female students) provided measurable data. Results. The occurrence of nonspecific LBP was high, with 29.1% students suffering from this condition in the past 3 months (24.7% in boys, 33.1% in girls). In addition, an increased occurrence was observed with age. The occurrences of LBP in 10 to 14 years and 15 to 18 years were 21.5% and 38.2%, respectively. In several aspects of LBP, statistically significant differences were observed between boys and girls, including the frequency of the pain (P = 0.003), the nature of the pain (P = 0.000), the likelihood of seeking for medical assistance (P = 0.007), the impact on normal daily life (P = 0.016), and the occurrence of LBP after bending over the desk for a period of time (P = 0.024). Female students had more frequent LBP and were less willing to see a physician. In addition, more female students (45/366) had LBP accompanied with radiating pain than male students (20/241). Conclusion. There is a high prevalence of LBP in Chinese schoolchildren. The occurrence of LBP increases with age in both sexes. LBP is significantly more prevalent in girls.
Clinical significance of Smac and Ki-67 expression in pancreatic cancer.

BACKGROUND/AIMS Tumors generally progress due to disruption in the balance between cellular proliferation and apoptosis. Thus, regulators of these processes tend to have altered expression in tumors, making them useful diagnostic and prognostic markers in the clinic. Here, we explored the potential usefulness of proteins involved in each of these processes, Smac (apoptosis) and Ki-67 (proliferation), in pancreatic cancer. METHODOLOGY We collected 35 pancreatic cancer samples and 12 normal pancreas samples and applied immunohistochemistry and pathology to determine the expression of these two proteins and their correlation with clinicopathology of the tumors. RESULTS Both Smac (35/35) and Ki-67 (33/35) were significantly more highly expressed in pancreatic tumors than in normal pancreas (1/12 and 2/12, respectively; p<0.05). However, no correlation was detected between Smac and Ki-67 expression in these tumors. Importantly, Smac expression was correlated only with pathological grade (p<0.05), while Ki-67 expression was correlated with pathological grade, lymph node metastasis, and clinical stage (p<0.05). CONCLUSIONS The higher expression of Smac and Ki-67 appear to play a role in the pathogenesis of pancreatic cancer. Combined detection of these proteins may improve the prognostic evaluation of this disease.
5G-enabled Edge Computing for MapReduce-based Data Pre-processing

The notion of edge computing, including fog computing, is to shift tasks to process data generated from sensing systems from the server-side to the network edge. Data directly measured by sensing systems tend to contain noise and loss and be in a non-canonical representation. Pre-processing for such data is often needed to reduce noise and to translate the data to a canonical representation. MapReduce processing, which was originally designed to be executed on a cluster of high-performance servers, is also useful for pre-processing data generated at the edge of a network. To support edge computing, we previously developed an approach to enable processing in embedded computers connected through wired or wireless local area networks in a peer-to-peer manner. The purpose of this paper is to extend our existing approach to give it the ability to work 5G networks. The extended approach connects nodes at the edge to base stations but not directly nodes. This paper describes the extension and its performance. The extension is based on our previous approach but has several contributions in common with other embedded computing systems for 5G networks.
Les factorisations en matrices non-négatives. Approches contraintes et probabilistes, application à la transcription automatique de musique polyphonique.

La transcription automatique de la musique est l'operation qui consiste, partant du seul contenu audio, a produire une representation symbolique (par exemple un fichier MIDI) d'un morceau de musique. Si la transcription de musique monodique est aujourd'hui bien maitrisee, le cas de la musique polyphonique est en revanche un probleme largement ouvert. Les decompositions de matrices en valeurs propres et en valeurs singulieres sont des techniques classiques d'algebre lineaire utilisees dans un grand nombre d'applications de traitement du signal. Elles permettent de representer efficacement les donnees observees en utilisant un nombre limite d'atomes elementaires. Contrairement a d'autres techniques de representations du signal, ces atomes ne sont pas recherches au sein d'un dictionnaire pre-defini, mais sont extraits des donnees elles-memes. La factorisation en matrices non-negatives (NMF) est une technique analogue d'algebre lineaire, qui reduit le rang tout en fournissant des atomes a valeurs exclusivement positives, plus facilement interpretables. Elle fournit conjointement un dictionnaire extrait des donnees et la decomposition de ces memes donnees dans ce dictionnaire. Ce memoire est consacre a l'etude theorique et experimentale detaillee de ces methodes. Il poursuit plusieurs objectifs : l'amelioration des performances des systemes de transcription qui les utilisent, de la pertinence semantique des representations mi-niveau produites, et du controle des proprietes theoriques et pratiques des algorithmes existants et originaux mis en œuvre au cours de la these.
Effects of checklist interface on non-verbal crew communications

The investigation looked at the effects of the spatial layout and functionality of cockpit displays and controls on crew communication. Specifically, the study focused on the intra-cockpit crew interaction, and subsequent task performance, of airline pilots flying different configurations of a new electronic checklist, designed and tested in a high-fidelity simulator at NASA Ames Research Center. The first part of this proposal establishes the theoretical background for the assumptions underlying the research, suggesting that in the context of the interaction between a multi-operator crew and a machine, the design and configuration of the interface will affect interactions between individual operators and the machine, and subsequently, the interaction between operators. In view of the latest trends in cockpit interface design and flight-deck technology, in particular, the centralization of displays and controls, the introduction identifies certain problems associated with these modern designs and suggests specific design issues to which the expected results could be applied. A detailed research program and methodology is outlined and the results are described and discussed. Overall, differences in cockpit design were shown to impact the activity within the cockpit, including interactions between pilots and aircraft and the cooperative interactions between pilots.
Posterior Cerebral Infarction following Loss of Guide Wire

Stroke after internal jugular venous cannulation typically leads to acute carotid or vertebral arteries injury and cerebral ischemia. We report the first case of delayed posterior cerebral infarction following loss of guide wire after left internal jugular venous cannulation in a 46-year-old woman with a history of inflammatory bowel disease. Our observation highlights that loss of an intravascular guide wire can be a cause of ischemic stroke in patients undergoing central venous catheterization.
TERAPIA RACIONAL EMOTIVA: UNA REVISION ACTUALIZADA DE LA INVESTIGACIÓN

Con la finalidad de llevar a cabo una actualizacion de la investigacion en Terapia Racional Emotiva, se hizo una revision de los ultimos cuatro anos de lo publicado en la revista Journal of Rational Emotive and Cognitive-Behavior Therapy. Se plantean las bases teoricas de la Terapia Racional Emotiva y se presentan los resultados de la revision bibliografica. En la misma, se encuentra que los principales temas de investigacion en el campo fueron el perfeccionismo, el uso del midnfulness, la procrastinacion, rumiacion y el afrontamiento al estres. Se plantea y discute la investigacion actual en este campo de la psicoterapia.
Eating Dysfunctions in College Women: The Roles of Depression and Attachment to Fathers

Abstract The authors examined the roles of depression and attachment to fathers in college women's eating dysfunctions. Three-hundred six undergraduate women completed (1) a diagnostic measure of eating dysfunctions that categorized them as asymptomatic, symptomatic but not eating disordered, or eating disordered; (2) 3 dimensional measures of attachment to fathers; and (3) a dimensional measure of depression. Depression was directly related to severity of participants' eating dysfunction; the eating-disordered group had scores consistent with clinical depression. After controlling for depression, 3 facets of attachment to fathers significantly differentiated the 3 groups.
Simulación de procesos híbridos de destilación-pervaporación para la deshidratación de soluciones acuosas de etanol

Se evaluaron procesos hibridos de separacion destilacion-pervaporacion mediante simulaciones realizadas por el acople entre el simulador comercial de procesos quimicos Aspen Plus 7.3® con Excel 2007® y Matlab R2012b®, se tomo como caso de estudio la deshidratacion del etanol debido a la importancia que tiene este compuesto para la industria del alcohol carburante. La evaluacion de los procesos hibridos se centro en el consumo de energia y los resultados fueron comparados con los obtenidos en referentes bibliograficos para los procesos de separacion no convencionales utilizados en la actualidad.