Miracle-dz/UniFAR-FTUs huggingface dataset:
The plurilingual classroom and ELT: The challenge to overcome tensions between aboriginal languages and hegemonic languages

This pedagogic proposal describes a CLIL (Content and Language Integrated Learning) project for the secondary school English language classroom that integrates English, art and citizenship education with the aim to promote a hetereglossic view of language practices in multicultural ELT classrooms and the development of intercultural competences in the framework of linguistic rights. The project is intended to be developed in twelve lessons with 15-16 year-olds. Students will read and research, through the use of different multimodal material, about the importance of preserving local aboriginal languages; they will also develop cooperative works (murals, bilingual version of English songs, timelines) that relate and integrate local languages with English.
Attentional Effects of Masked Famous Faces (But Not Names) and Subjective Evaluations of a Target Person

Two experiments are reported using a 1986 version of the dot-probe paradigm of MacLeod, Mathews, and Tata, in which the masked subliminal faces of famous persons were differentially associated with attention depending on participants' attitudes toward the famous person. There was attentional avoidance of the faces of persons invoking high disgust (Exp. 1, n = 20) or dislike (Exp. 2) but attentional orientation toward the faces of persons invoking low disgust or liking. In Exp. 2 (n = 28), this effect was apparent for the faces but not the names of famous persons, despite evidence that the famous names were recognised without awareness. The aversion of attention from faces, but not the names of famous persons who are regarded in a negative light but who are not particularly threatening, may suggest an automatic tendency to avoid making eye contact with an undesirable person thereby avoiding unwanted social interaction.
Analisis Kemampuan Earning untuk Memprediksi Future Operating Cash Flow pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Jakarta

This research is a case study on manufacturing firms engaged in consumption that go public on the Jakarta Stock Exchange. The purpose of this study was to analyze the influence of accrual and cash flow to future operating cash flow in companies manufacturing sector consumption listed in the Jakarta Stock Exchange. This study uses linear regression to see the large contribution of each independent variable in influencing the future operating cash flow. The hypothesis of this research is the accrual and cash flow on future operating cash flow. Based on the results of t test is concluded, that the most significant variables affect future operating cash flow. The results showed that both in aggregate earnings and divided into the accrual and cash flow components have a significant impact on future operating cash flow.
Characterization of the Dictyostelium Homolog of Chromatin Binding Protein DET1 Suggests a Conserved Pathway Regulating Cell Type Specification and Developmental Plasticity

ABSTRACT DET1 (De-etiolated 1) is a chromatin binding protein involved in developmental regulation in both plants and animals. DET1 is largely restricted to multicellular eukaryotes, and here we report the characterization of a DET1 homolog from the social amoeba Dictyostelium discoideum. As in other species, Dictyostelium DET1 is nuclear localized. In contrast to other species, where it is an essential protein, loss of DET1 is nonlethal in Dictyostelium, although viability is significantly reduced. The phenotype of the det1− mutant is highly pleiotropic and results in a large degree of heterogeneity in developmental parameters. Loss of DET1 results in delayed and abnormal development with enlarged aggregation territories. Mutant slugs displayed cell type patterning with a bias toward the prestalk pathway. A number of DET1-interacting proteins are conserved in Dictyostelium, and the apparently conserved role of DET1 in regulatory pathways involving the bZIP transcription factors DimB, c-Jun, and HY5 suggests a highly conserved mechanism regulating development in multicellular eukaryotes. While the mechanism by which DET1 functions is unclear, it appears that it has a key role in regulation of developmental plasticity and integration of information on environmental conditions into the developmental program of an organism.
Drinking typography established by scheduled induction predicts chronic heavy drinking in a monkey model of ethanol self-administration.

BACKGROUND We have developed an animal model of alcohol self-administration that initially employs schedule-induced polydipsia (SIP) to establish reliable ethanol consumption under open access (22 h/d) conditions with food and water concurrently available. SIP is an adjunctive behavior that is generated by constraining access to an important commodity (e.g., flavored food). The induction schedule and ethanol polydipsia generated under these conditions affords the opportunity to investigate the development of drinking typologies that lead to chronic, excessive alcohol consumption. METHODS Adult male cynomolgus monkeys (Macaca fascicularis) were induced to drink water and 4% (w/v in water) ethanol by a Fixed-Time 300 seconds (FT-300 seconds) schedule of banana-flavored pellet delivery. The FT-300 seconds schedule was in effect for 120 consecutive sessions, with daily induction doses increasing from 0.0 to 0.5 g/kg to 1.0 g/kg to 1.5 g/kg every 30 days. Following induction, the monkeys were allowed concurrent access to 4% (w/v) ethanol and water for 22 h/day for 12 months. RESULTS Drinking typographies during the induction of drinking 1.5 g/kg ethanol emerged that were highly predictive of the daily ethanol intake over the next 12 months. Specifically, the frequency in which monkeys ingested 1.5 g/kg ethanol without a 5-minute lapse in drinking (defined as a bout of drinking) during induction strongly predicted (correlation 0.91) subsequent ethanol intake over the next 12 months of open access to ethanol. Blood ethanol during induction were highly correlated with intake and with drinking typography and ranged from 100 to 160 mg% when the monkeys drank their 1.5 g/kg dose in a single bout. Forty percent of the population became heavy drinkers (mean daily intakes >3.0 g/kg for 12 months) characterized by frequent "spree" drinking (intakes >4.0 g/kg/d). CONCLUSION This model of ethanol self-administration identifies early alcohol drinking typographies (gulping the equivalent of 6 drinks) that evolve into chronic heavy alcohol consumption in primates (drinking the equivalent of 16 to 20 drinks per day). The model may aid in identifying biological risks for establishing harmful alcohol drinking.
Natural history of primary snoring in school-aged children: a 4-year follow-up study.

BACKGROUND The objective of this study was to examine the natural history of childhood primary snoring (PS) and to identify predictive clinical symptoms and risk factors associated with PS progression to obstructive sleep apnea (OSA). METHODS Children aged 6 to 13 years old who received a diagnosis of PS in our previous community-based OSA prevalence study were invited to undergo repeat polysomnography (PSG) at 4-year follow-up. Subjects with an obstructive apnea hypopnea index (OAHI) ≥ 1 were classified as having OSA at follow-up. RESULTS Seventy children (60% boys) with a mean age of 14.7 ± 1.8 years were analyzed in this follow-up study. The mean duration of follow-up was 4.6 ± 0.6 years. At follow-up, 26 subjects (37.1%) progressed to OSA, of whom five (7.1%) had moderate to severe disease (OAHI ≥ 5). Twenty-two (31.4%) remained at PS, and 18 (25.7%) had complete resolution of their snoring with normal PSG. Persistent snoring had a positive predictive value of 47.7% and a negative predictive value of 86.4% for progression from PS to OSA. Multivariate logistic regression analysis showed that persistent overweight/obesity was a significant risk factor for the development of OSA at follow-up, with an OR of 7.95 (95% CI, 1.43-44.09). CONCLUSIONS More than one-third of school-aged children with PS progressed to OSA over a 4-year period, although only 7.1% developed moderate to severe disease. Weight control may be an important component in the management of PS because obesity was found to be a significant risk factor for PS progression.
Gender Equity in Contemporary Marriages: The Decision Making Perspective

The female gender, more especially, has not benefitted from gender equity arrangement in Nigeria mostly due to socio-cultural constraints and non-possession of empowering instruments. This is most evident in marriages which are enduring contact point for adult males and females. However; with the contracting of contemporary marriages that is apparently characterized by lesser regard for traditional gender-disparity values, and increasing socio-economic equality of spouses, this paper found it imperative to examine gender equity in such marriages with particular focus on decision making. Quantitative data was obtained from 665 respondents who had been in contemporary marriage in the last 20 years in the Benin metropolis. The nature of decision making as it affects the ability of a spouse to access opportunities and resources was measured with the giving of “approval” or not. Perception on equal decision making between spouses was measured using a five-response Likert scale made up of four Liken-type items. Results indicate significantly high odds of a husband not approving of his wife acquiring higher education, registering and participating in politics, and individually acquiring property. Also significant difference exist in the perception of equal decision making between male and female; and there is a significant relationship between the age of spouses and their disposition towards equal decision making. Accordingly, it is recommended that empowering females should be sustained and negative perception of equal decision making between spouses should be eroded.
Association of adiponectin receptor (Adipo-R1/-R2) expression and colorectal cancer.

INTRODUCTION Human adiponectin (ApN) is a 30 kDa glycoprotein of 244-amino acids which is extensively produced by adipocytes. ApN acts via two receptors, namely adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Studies have shown the presence of Adipo-R1 and Adipo-R2 expression immunohistochemically in human colorectal cancers (CRCs). However, only a few studies exist which investigated effects of adiponectin receptor expression on CRC characteristics. OBJECTIVES In the present study, we aimed to explore Adipo-R1/-R2 expression in human colorectal cancers and any association with clinicopathological characteristics and survival. MATERIALS AND METHODS The study enrolled 58 colorectal cancer patients with tumor resection and a control group of 30 subjects with normal colon mucosa. RESULTS Positivity for Adipo-R1/-R2 expression was significantly more common in the control group in comparison to the patient group (both p<0.001). There was no significant association between Adipo-R1/-R2 expression and clinicopathological characteristics including age, sex tumor location, pTNM stage, Duke's stage, metastasis, histological differentiation, perineural invasion, venous invasion sex, lymphatic invasion, cancer-related mortality, tumor size and recurrence. Adipo- R1/-R2 positivity was also not significantly linked to progression-free or overall survival [p values (0.871, 0.758 ) and (0.274, 0.232), respectively]. CONCLUSIONS Although significantly reduced Adipo-R1/-R2 expression was found in colorectal cancer patients, it had no influence on survival.
Enhancement of murine macrophage binding of and response to bacterial lipopolysaccharide (LPS) by LPS‐binding protein

We have studied the effects of highly purified rabbit lipopolysaccharide (LPS)‐binding protein (LBP) on the ability of murine bone marrow‐derived macrophages to respond to bacterial LPS. Macrophage responses studied include the secretion of tumor necrosis factorα, production of arginine‐derived nitrite (NO2−), and killing of an intracellular pathogen, Leishmania enriettii. Macrophages from either CBA or LPS‐hyporesponsive C3H/HeJ mice exhibited significantly greater sensitivity to LPS in the presence of LBP Furthermore, both CBA and C3H/HeJ macrophages demonstrated an LBP‐depen‐ dent enhancement of LPS binding. These results suggest that C3H/HeJ macrophages are capable of binding LPS‐ LBP complexes and support the hypothesis that hypo‐ responsiveness in this strain involves a step subsequent to LPS binding. Furthermore, these findings provide additional evidence of the important role played by the acute‐ phase plasma protein LBP in modifying host response to LPS.
Distributional Impacts of Energy Taxes

Despite popularity among economists for their efficiency, energy pollution taxes enjoy less political support than standards-based regulation because of common perceptions that they burden the poor relative to the rich. However, the literature on pollution tax incidence and consumption surveys in Mexico, the United Kingdom, and the United States, suggest energy taxes need not be as regressive as often assumed. This paper demonstrates that the incidence of such taxes varies according to the energy commodities that are taxed, the physical, social and climatic characteristics of jurisdictions in which they are implemented, and how the revenue is used. It is also shown that the variation in household energy expenditure within income groups is greater than variation across income groups in many cases. These horizontal equity impacts are reviewed, as are their implications for policy making.
Design of highly emissive polymer dot bioconjugates for in vivo tumor targeting.

Nanoparticle-based diagnostic and therapeutic agents have attracted considerable interest because of their potential for clinical oncology and other biomedical research. [1] Versatile nanostructures have been demonstrated for in vivo applications, such as lipid and polymeric nanocapsules for drug delivery,[2] iron oxide nanoparticles for magnetic resonance imaging,[3] gold nanoparticles for X-ray computed tomography,[4] and quantum dots (Qdots) for fluorescence imaging. [5] Qdots represent one of the exciting nanotechnologies translated to biology in the past decade. The size-tunable luminescence makes them appealing as multicolor fluorophores for biological labelling, imaging, and sensing. [6,7] For in vivo applications, however, the intrinsic toxicity of Qdots is of critical concern,[8] which may impede their final clinical translation. Therefore, the design of bright probes with biologically benign materials is highly desirable for many in vivo clinical applications.
Photographer preference or image purpose? An investigation of posing bias in mammalian and non-mammalian species

Portraits of human adults typically exhibit leftward biases—that is, they depict individuals with their left cheek prominently featured. The purpose of this study was to determine if photographs of human infants and photographs of non-human animals also display these leftward biases. We observed significant leftward biases in photographs of infants and non-human animals. The only exception to this was a rightward bias observed for photographs of non-mammalian species that were found on personal websites. As the species sampled were likely unaware of the purpose of the photographs, our data are consistent with the interpretation that these biases reflect the preference of the photographer.
A Krein Space Approach to  $H_{\infty}$ Filtering of Discrete-Time Nonlinear Systems

In this paper, a Krein space approach to finite horizon H∞ filtering is proposed for a class of affine nonlinear discrete-time systems. It is shown that the problem of H∞ nonlinear filtering can be converted into a minimum of an indefinite quadratic form. Hence, a relationship between H∞ nonlinear filter in Hilbert space and nonlinear estimation in Krein space is established. By using first-order Taylor approximation and Krein space projection, a sufficient and necessary condition for the minimum is derived. Moreover, a feasible solution of the H∞ nonlinear filter can be obtained by recursively computing Riccati recursions. Finally, a numerical example and one kind of integration filter are used to demonstrate the effectiveness of the proposed method.
Localization algorithm for large-scale wireless sensor networks based on FCMTSR-support vector machine

Sensor node localization is one of research hotspots in the applications of wireless sensor network field. A localization algorithm is proposed in this article which is based on improved support vector machine for large-scale wireless sensor networks. For a large-scale wireless sensor network, localization algorithm based on support vector machine faces to the problem of the large-scale learning samples. The large-scale training samples will lead to high burden of the training calculation, over learning, and low classification accuracy. In order to solve these problems, this article proposed a novel scale of training sample reduction method (FCMTSR). FCMTSR takes the training sample as point set, get the potential support vectors, and remove the non-boundary outlier data immixed by analyzing relationships between points and set. To reduce the calculation load, fuzzy C-means clustering algorithm is applied in the FCMTSR. By the FCMTSR, the training time is reduced and the localization accuracy is improved. Through the simulations, the performance of localization based on FCMTSR-support vector machine is evaluated. The results prove that the localization precision is improved 2%, the training time is reduce 55% than existing localization algorithm based on support vector machine without FCMTSR. FCMTSR-support vector machine localization algorithm also addresses the border problem and coverage hole problem effectively. Finally, the limitation of the proposed localization algorithm is discussed and future work is present.
The rs1447295 and DG8S737 markers on chromosome 8q24 and cancer risk in the Polish population

Several recent association studies implicate three neighbouring regions of chromosome 8q24 as the site of prostate cancer susceptibility loci. One region contains both a microsatellite marker DG8S737 and a single nucleotide polymorphism rs1447295. Both have been consistently associated with prostate cancer risk in several populations. However, studies to date have not inquired whether the susceptibility associated with this particular region of 8q24 extends to other cancer sites. We genotyped 3822 cases of cancer of various sites and 1807 controls for rs1447295 polymorphism. A positive association was seen for prostate cancer, but not for any of the other sites studied [odds ratios (ORs) ranging from 0.8 to 1.1]. Prostate cancer cases and controls were genotyped for both rs1447285 and DG8S737. Significant ORs were observed for the A allele of rs1447285 (OR = 1.4; P = 0.01) and the −8 allele of DG8S737 (OR = 1.6; P = 0.006). The association was particularly strong for men with familial prostate cancer (OR = 2.0, P = 0.004 for the A allele; OR = 3.5, P<0.0001 for the −8 allele). The OR associated with the A allele of rs1447295 was slightly higher for aggressive tumours (Gleason score 8 or more) (OR = 1.5), than for tumours with Gleason score 7 and below (OR = 1.3). In conclusion, the relationship between the rs1447295 and DG8S737 polymorphic variants on chromosome 8q24 and prostate cancer risk is seen in the Polish population to a similar degree as it has been observed elsewhere. Although the carcinogenic mechanism associated with this particular locus of 8q24 is unclear it appears to be specific to prostate cancer.
Human resource management and employee well-being: towards a new analytic framework

The mutual gains model suggests that HRM should benefit both individuals and organisations. However, the dominant models within HRM theory and research continue to focus largely on ways to improve performance, with employee concerns very much a secondary consideration. Furthermore, pressures at work and in society more widely are creating an increasing threat to employee well-being. If employee concerns and the threats to well-being are to be taken seriously, a different analytic framework for HRM is required. The article sets out an alternative approach to HRM that gives priority to practices designed to enhance well-being and a positive employment relationship, proposing that both elements are essential. Evidence is presented to support the choice of practices and to argue that these also hold the potential to improve both individual and organisational performance. It therefore offers a different path to mutual gains. The research and policy implications of this approach are discussed.
Changing from intermittent to continuous water supply and its influence on service level benchmarks: a case study in the demonstration zone of Nagpur, India

Abstract A dearth in infrastructure and operations significantly reduces the expected benefits of safe drinking water provision. Intermittent water supplies are characterized by inefficient demand and supply management owing to operational inadequacies eventually causing physical deterioration of infrastructure and inconvenience to consumers, resulting in consumer dissatisfaction. Conversion from intermittent to continuous water supply was undertaken in a demonstration zone of Nagpur, India, with a population of about 150,000 people. Data related to the infrastructural, operational, managerial and financial capabilities were used to determine service level benchmarks (SLBs) — pre- and post-intervention — to quantify the improvement due to continuous water supply interventions. The post-intervention data analysis clearly indicated substantial improvement in post-intervention SLBs, consequently paving the way for the conversion of the water supply of the entire city to continuous mode.
Simultaneous determination of polymorphism in N-acetyltransferase 1 and 2 genes by reverse line blot hybridization.

Polymorphism in N-acetyltransferases NAT1 and NAT2 may contribute to differences in cancer susceptibility of subjects exposed to alkylating compounds. We developed a robust method for simultaneous determination of these NAT polymorphisms: Reverse line blot (RLB) hybridization, based on PCR followed by allele-specific oligo hybridization. On a membrane, allele-specific oligonucleotide probes of the NAT genes (NAT1*4, *3, *10, *11 and NAT2*4, *5, *6, *7, *12) were applied in lines. After separate amplification of the NAT genes, simultaneous hybridization of these products in lines perpendicular to the lines with oligonucleotide probes was performed, followed by nonradioactive detection. This resulted in hybridization patterns, representing the NAT genotype of an individual. RLB hybridizations were conducted on DNA from 240 Dutch Caucasian participants in an ongoing case-control study on colorectal adenoma (including 126 polyp-free control subjects). Results were in complete agreement with those obtained by commonly used methods, i.e., allele-specific PCR and PCR-RFLP. Allele-frequencies in the polyp-free control group were similar to those described in the literature. RLB hybridization is, however, considerably faster and cheaper than the common assays. Moreover, expansion with allelic variants of other genes is relatively easy, which makes RLB hybridization very useful for multiplex analysis of numerous polymorphisms in epidemiological studies.