Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrin cell adhesion molecules and colorectal cancer

The extracellular matrix (ECM) is a complex meshwork of proteins and carbohydrates which are synthesized and deposited in the vicinity of cells forming an organized intercellular network. The matrix not only provides a mechanical support where cells reside, but also has a dynamic function controlling cell shape, proliferation, migration, polarity, and differentiation. ' Specific receptors for several extracellular matrix proteins such as collagens, fibronectin, and laminin have been identified on various normal and transformed cells. ' There is evidence to suggest that these receptors may mediate the effects of extracellular matrix proteins on cell proliferation and differentiation via their structural link with cytoskeleton molecules such as actin, vinculin, and ta l i r~ . ~ In colorectal cancer, as in other malignant tumours, there is a prominent stroma containing known components of the normal ECM, including collagens (types I, 11, 11, V, and VI), fibronectin, and several prote~glycans. ~ In addition, a basement membrane composed of type IV collagen, entactin, nidogen, heparin sulphate, and other extracellular matrix proteins is normally interposed between the tumour cells and stroma with gaps, duplication, and fragmentation, particularly at points where the tumour appears to be inva~ive . ~ In recent years, there has been increasing evidence for the active role played by extracellular matrix proteins in controlling proliferation, differentiation, and gene expression of the tumour, as well as normal cells in vitro. ' Therefore there have been several attempts to investigate whether the grade of malignancy and invasiveness of a tumour in vivo could be explained in terms of abnormal distribution and function of ECM proteins and/or their abnormal interaction with tumour cells. No correlation has been found between the degree of tumour malignancy and the amount of collagens4 or fibronectin in the tumour
Autonomic function in reflex and non‐reflex epilepsy – an exploratory study

Seizures are known to affect diverse areas of the Central Autonomic Network (CAN) resulting in varied autonomic symptoms. The objectives of the study were to characterize neuro‐cardiac autonomic regulation in hot water epilepsy (HWE) with or without spontaneous seizure, and to analyze the effect of Carbamazepine (CBZ).
The early clinical diagnosis of osteoarthritis of the hip.

Osteoarthritis of the hip is a common condition physical therapists see in the clinic. The fundamental radiological and pathological characteristic of osteoarthritis of the hip is joint space loss. Consequently, the best radiological criterion used to detect osteoarthritis of the hip is by measuring joint space width. Because most physical therapists do not have immediate access to radiographs and do not have the ability to order radiographs, they must either rely on a physician to order a hip radiograph or rely on a clinical method to diagnose osteoarthritis of the hip. Radiographs, though usually helpful in the diagnosis of severe hip osteoarthritis, are not always beneficial in the diagnosis of mild or moderate hip osteoarthritis. In patients with severe hip osteoarthritis, radiographs usually show joint space narrowing, subchondral sclerosis, or osteophytes. However, patients with early osteoarthritis often do not show these kind of radiographic changes. Thus, relying only on radiographs to determine .
Research on unobservability problem for two-dimensional bearings-only target motion analysis

The observability for bearings-only target motion analysis is a very important problem. The bearings-only system is to be said observable if and only if the target motion parameters can be uniquely determined by noise-free bearing measurements. The problem of unobservability for hearing-only target tracking system is discussed in this paper based on the target that travels in the 2-dimentional space with a constant acceleration. Utilizing Gramm rule and rank of matrix, a new proposition that the bearing-only locating and tracking system remains unsolvable prior to an observer maneuver is presented and proved. By proving the proposition, it is shown that for certain type of observer movement the estimation process remains unobservable, even if the target moves with a constant accelerate. The work done in this paper is a valuable study in solving the bearings-only target motion analysis.
Aplicação do lean startup para a definição dos atributos de um serviço IoT

A disponibilidade de utilização de tecnologias digitais, tais como as denominadas de Internet of Things (IoT) tem apresentado a oportunidade de desenvolvimento de diversas possibilidades de negócio. Associado a estas oportunidades, o método Lean Startup tem por objetivo agilizar o projeto de novos negócios baseados principalmente em tecnologias digitais. Este artigo tem por objetivo reunir estas duas abordagens, por meio da aplicação do método de Lean Startup no desenvolvimento de um aplicativo que utiliza as tecnologias IoT. A partir disso, este artigo tem por objetivo realizar um ciclo de projeto seguindo o método de Lean Startup para a definição do Mínimo Produto Viável (MVP) de um aplicativo com tecnologias IoT. Foi realizada uma pesquisa de levantamento com 158 respondentes utilizando o método de análise conjunta baseada em escolhas. Os resultados da análise de regressão logística (Logit) indicam que os cinco atributos identificados para o aplicativo apresentam contribuição significativa (p-valor<0,05) na agregação de valor do serviço. A partir dos resultados foi possível direcionar o desenvolvimento do aplicativo para os atributos mais direcionados a escala de valor dos clientes.
Educating Staff in Food Hygiene

poisoning outbreaks and the emergence of hygiene problems with particular foods have given consumers a greater awareness of food safety. Over the last 10-15 years the catering industry has undergone a great deal of change. It has now become, in many sectors, a high-tech industry. IJnfortunately the level of awareness of food hygiene and food quality has not kept pace with these developments. Therefore we now have to raise our standards of operation in order to guarantee food safety to our customers. The publication of the Training Consultative document and the passing of the Food Safety Act have already brought
Risk Factors for Cervical Cancer: Results from a Hospital-Based Case-Control Study

The aim of this study was to investigate risk factors for cervical cancer in Turkish women. In a hospital-based case-control study in ‹stanbul, 209 patients with histologically confirmed cervical cancer were compared with 1050 controls, who were admitted to the different departments of the same hospital. Odds ratios (OR) and 95% confidence intervals (CI) were obtained from multivariate logistic regression analysis, fitted by the method of maximum likelihood. Risk factors for cervical cancer were found to be early age at first sexual intercourse (OR = 58.07, 95% CI: 27.88-120.95) and history of genital infection (OR = 5.17, 95% CI: 3.51-7.60). However, compared with controls, it was found that cases including higher education (OR = 0.18, 95% CI: 0.10-0.30), non-married (OR = 0.07, 95% CI: 0.04-0.12) and non-use of alcohol (OR = 0.30, 95% CI: 0.14-0.65) had a decreased risk for cervical cancer. Our results are supportive of the hypothesis that early age at first sexual intercourse and history of genital infection is related with the risk factors for cervical cancer. Therefore, monogamy, late commencement of sexual activity, personal hygiene and use of barrier contraceptive methods help towards primary prevention.
Human and mouse homologs of Escherichia coli DinB ( DNA polymerase IV ) , members of the UmuC y DinB superfamily

To understand the mechanisms underlying mutagenesis in eukaryotes better, we have cloned mouse and human homologs of the Escherichia coli dinB gene. E. coli dinB encodes DNA polymerase IV and greatly increases spontaneous mutations when overexpressed. The mouse and human DinB1 amino acid sequences share significant identity with E. coli DinB, including distinct motifs implicated in catalysis, suggesting conservation of the polymerase function. These proteins are members of a large superfamily of DNA damage-bypass replication proteins, including the E. coli proteins UmuC and DinB and the Saccharomyces cerevisiae proteins Rev1 and Rad30. In a phylogenetic tree, the mouse and human DinB1 proteins specifically group with E. coli DinB, suggesting a mitochondrial origin for these genes. The human DINB1 gene is localized to chromosome 5q13 and is widely expressed.
Michel Foucault: discourse in the modern medical consultation

This year will mark the 30th anniversary of the death of Michel Foucault. His contributions to the fields of philosophy, medical sociology and critical theory are considerable. However, as Hodges et al. recognise in this issue, mentions of Foucault’s work in medical journals are rare, except in publications which identify themselves as interdisciplinary and as crossing the boundaries between the social and medical sciences. When we consider why this may be, the possible reasons are widespread across the literature. The work of Foucault has been criticised as impenetrable (even by himself), often paradoxical and detached from the current realities of the institutions it describes. This perhaps explains its absence from biomedical spheres. However, much can be learned from Foucault’s seminal work on health care and institutions, and its broader interpretations and implications have great resonance for medical education.
Comparative perspectives on urban housing conditions

The objective of the analysis is to highlight the most significant aspects of change in the housing conditions of cities under study in the sub-region. We have focused on tenure transformation and affordability of housing with a particular emphasis on differences and similarities in these processes of change. The methodology used draws on the HABITAT urban and housing indicators. Data was collected by local experts in 18 cities in the sub-region under the methodological guidance of the Metropolitan Research Institute (MRI), Budapest. The following sections address patterns of tenure change, affordability of housing as well as emerging policy challenges associated with growing poverty.
A compositional framework for Markov processes

We define the concept of an “open” Markov process, or more precisely, continuous-time Markov chain, which is one where probability can flow in or out of certain states called “inputs” and “outputs. ” One can build up a Markov process from smaller open pieces. This process is formalized by making open Markov processes into the morphisms of a dagger compact category. We show that the behavior of a detailed balanced open Markov process is determined by a principle of minimum dissipation, closely related to Prigogine’s principle of minimum entropy production. Using this fact, we set up a functor mapping open detailed balanced Markov processes to open circuits made of linear resistors. We also describe how to “black box” an open Markov process, obtaining the linear relation between input and output data that holds in any steady state, including nonequilibrium steady states with a nonzero flow of probability through the system. We prove that black boxing gives a symmetric monoidal dagger functor sending open det.
The Attitudes and Behaviors of Current Medical Students towards Business Education and Training

Medical students often look into owning their own practice as an option for their career. However, many of them do not acquire the proper training for owning and operating a business, and ultimately end up making costly mistakes. Thus, the purpose of this study is to gauge how medical students perceive the importance of business education and training. Based on survey data from 137 current medical students from across the United States, our study found that the vast majority of medical students believe that business education and training is valuable. However, today’s MD/MBA programs do not appear to meet the current needs of medical students, as a broad MBA degree may not be the best fit for most medical students. Thesis Mentor: _______________________ Dr. Steven Charlier Honors Director: ______________________ Dr. Steven Engel December 2017 College of Business University Honors Program Georgia Southern University
A Model for Automatic Extraction of Slowdowns From Traffic Sensor Data

The ability to identify slowdowns from a stream of traffic sensor readings in an automatic fashion is a core building block for any application which incorporates traffic behaviour into its analysis process. The methods proposed in this paper treat slowdowns as valley-shaped data sequences that are found below a normal distribution interval. This paper proposes a model for slowdown identification and partitioning across multiple periods of time and it aims to serve as a first layer of knowledge about the traffic environment. The model can be used to extract the regularities from a set of events of interest with recurring behaviour and to assert the consistency of the extracted patterns. The proposed methods are evaluated using real data collected from highway traffic sensors
Hereditary Gastrointestinal Polyposis Syndromes: A Review Including Newly Identified Syndromes

There are multiple hereditary and non-hereditary polyposis syndromes that were originally categorized as adenomatous or hamartomatous. More recently, serrated polyps and their syndromes have been defined. Nearly all of these syndromes have a risk of colorectal cancer in the individuals and affected family members. Most of these syndromes are associated with extracolonic manifestations, including extracolonic tumors. The major clinical features, genetic mechanisms, and clinical management of Familial Adenomatous Polyposis (FAP), Peutz-Jeghers Syndrome (PJS), Juvenile Polyposis Syndrome (JPS), PTEN Hamartoma Syndrome (PTHS), and the more recently described syndromes MUTYH-Associated Polyposis, Hereditary Mixed Polyposis Syndrome, Serrated Polyposis Syndrome, and Polymerase Proofreading Associated Polyposis are summarized in this article.
Risk factors of urinary tract infection in pregnancy.

OBJECTIVES To determine the frequency, risk factors and pattern of urinary complaints during pregnancy. METHODS A descriptive study was conducted in the Obstetric and Gynaecology Department of Isra University Hospital, Hyderabad from 1st January to 30th August 2008. Total 232 women were selected to ascertain the frequency and pattern of urinary symptoms as well as the risk factors of urinary tract infection (UTI) such as age, parity, education, past history of UTI and haemoglobin among women attending an antenatal clinic. All pregnant women irrespective of age, parity and gestational age were included, while women with known underlying renal pathology, chronic renal disease, renal transplant, diabetes or taking immunosuppressant therapy were excluded. Informed consent was taken and data collected on a self designed proforma. All the women underwent complete examination of urine. Dipstick test was performed on midstream urine and urine was cultured incase of positive dipstick test and women with urinary symptoms. Data was analyzed on SPSS version 11. Odds ratio and 95% confidence interval were calculated among the categorical parameters by applying the Fisher's exact test. RESULTS Out of 232 women, 108(46.5%) reported urinary symptoms which were due to pregnancy induced changes on urinary system as no growth was obtained on urine culture, while 10 (4.3%) were due to underlying UTI. Most common urinary symptom in these women was abnormal voiding pattern 85 (40.3%) followed by irritative symptoms and voiding difficulties. Illiteracy, history of sexual activity, low socioeconomic (monthly income < Rs. 10,000 / month) group, past history of UTI and multiparity were found to be risk factors for UTI in these women. On complete urine examination, 222 (95.6%) patients either did not reveal any pus cells or had less than 5 WBC/HPF. Out of 108 cultures, only 10 (4.3%) specimens showed growth. E-coli was the most commonly detected organism 7 (3%) followed by S-aureus in 3 (1.3%). CONCLUSION The common urinary symptoms encountered in the studied women were abnormal voiding pattern followed by irritative symptoms. Majority of urinary symptoms were due to pregnancy related changes in the urinary system. Past history of UTI, sexual activity, lower socioeconomic group and multi parity were significant risk factors for UTI.
Survey on Resource Allocation in Phase-Level using MapReduce in Hadoop

: MapReduce is programming tool for Hadoop cluster. While allocating resources, MapReduce has two levels: Task-level and Phase-level. These levels should be used to check performance of each job. In existing system, the scheduling is focus on task level which tasks can have highly varying resource requirements during their lifetime and also its difficult to effectively utilize available resources to reduce job execution time. To address this limitation, this project proposes a PRISM (Phase and Resource Information - aware Scheduler MapReduce) which allocates a fine-grained resource at the phase-level to perform job scheduling. The job scheduling of prism is performed by the master node, which maintains a list of jobs in the system. Each node manager (slave node) periodically sends a heartbeat message to the scheduler. Upon receiving the status message from a node manager running on machine, the scheduler computes the utilization for set of candidate phases for the tasks using the jobs phase-level resource requirement. Then it select the phase with the highest utility for scheduling and update the resource utilization of the machine. This process is continued for until scheduled the phases of map and Reduce task is completed.
Landslide Inventory and Susceptibility Assessment for the Ntchenachena Area, Northern Malawi (East Africa)

Similar to other parts of the world, landslides are not a new phenomenon in Africa. They have been reported in Cameroon, Kenya, Uganda, Rwanda, Tanzania, and Ethiopia (Moeyerson 1988; 1989a; 1989b; Davies 1996; Westerberg and Christiansson 1998; Ngecu and Mathu 1999; Ingang’a and Ucakuwun 2001; Muwanga et al. 2001; Knapen et al. 2006). The East African region which includes Malawi, is a heterogeneous in terms of physiography, geomorphology and rainfall, and has a high susceptibility to slope movement. The high annual rainfall, high weathering rates, deforestation and slope material with a low shear resistance or high clay content are often considered the main preconditions for landslides (Knapen et al. 2006).
BRCA1 Contributes to Cell Cycle Arrest and Chemoresistance in Response to the Anticancer Agent Irofulven

Tumor suppressor gene BRCA1 is frequently mutated in familial breast and ovarian cancer. BRCA1 plays pivotal roles in maintaining genomic stability by interacting with numerous proteins in cell cycle control and DNA repair. Irofulven (6-hydroxymethylacylfulvene, HMAF, MGI 114, NSC 683863) is one of a new class of anticancer agents that are analogs of mushroom-derived illudin toxins. Preclinical studies and clinical trials have demonstrated that irofulven is effective against several tumor cell types. The exact nature of irofulven-induced DNA damage is not completely understood. We demonstrated previously that irofulven activates ATM and its targets, NBS1, SMC1, CHK2, and p53. In this study, we hypothesize that irofulven induces DNA double-strand breaks and that BRCA1 may affect chemosensitivity by controlling cell cycle checkpoints, DNA repair, and genomic stability in response to irofulven treatment. We observed that irofulven induces the formation of chromosome breaks and radials and the activation and foci formation of γ-H2AX, BRCA1, and RAD51. We also provided evidence that irofulven induces the generation of DNA double-strand breaks. By using BRCA1-deficient or -proficient cells, we demonstrated that in response to irofulven, BRCA1 contributes to the control of S and G2/M cell cycle arrest and is critical for repairing DNA double-strand breaks and for RAD51-dependent homologous recombination. Furthermore, we found that BRCA1 deficiency results in increased chromosome damage and chemosensitivity after irofulven treatment.
Comparing customer satisfaction in hyper stores in different parts of Delhi

The customer satisfaction not only a frill but as a foundation of retail store growth, today the focus has been shifted from financial benefits to soft areas where customer expectations are matched with retail stores performance. Better service quality is the only solution in the hands of retailers for the success of the retail grocery stores. A comparison between expectations and performance is known as service quality. Customer satisfaction is based on perceived service quality. Service quality is a vital factor for the success of the firm. Customer satisfaction occupies prominent position literarily in general as well as specifically in retail stores. The present study is an exploratory research work that was focused on comparison between the customer satisfactions in hyper stores operating in different parts of Delhi. A sample of 200 customers was considered for study.100 customers were taken from South-West Delhi and 100 were taken from NorthEast Delhi. Sample includes both male and female respondents. Data was collected from six different hyper stores. Three stores were from South-West Delhi and rest three stores from NorthEast Delhi. Random convenient sampling was used. Results revealed that there was no significant difference between the customer satisfaction.
Entrepreneurship Among Tribal Women in Artisanal Clusters in the North East: A Case Study of Mizoram

The North-Eastern (NE) states of India have the largest concentration of handlooms in the country (more than 65 per cent of the total looms). However, a large majority (62%) of the looms in NE states are engaged in domestic production only. Thenzawl, a remote handloom cluster in Mizoram, located in India’s North-East has thrived and grown and become a pool of entrepreneurship for the underprivileged tribal women. The weavers in this remote town have redefined the quintessential ‘marginalised woman weaver’ as a strongly motivated woman entrepreneur, who has transformed the role of weaving from being a mere wage earning activity or a domestic chore to a commercially viable enterprise, notwithstanding the number of looms owned. This paper has attempted to trace the growth of the Thenzawl handloom cluster, in terms of number of enterprises, number of looms, number of products manufactured and so on, on the basis of mapping undertaken by the researcher and also offers suggestions to initiate cluster development initiatives to enable the enterprises to sustain and grow.
SIVcpz in wild chimpanzees.

West-central African chimpanzees ( Pan troglodytes troglodytes ) harbor strains of simian immunodeficiency virus (SIVcpz) that are closely related to all three groups of human immunodeficiency virus 1 (HIV-1) (M, N, and O) and have thus been implicated as a reservoir for human infection ([1][1]).
Does Global Investor Sentiment Encourage Capital Inflows?: Evidence from Korea

This paper examines the effect of global investor sentiment on capital inflows in the Korean stock and bond markets. First, we conclude that global investor sentiment about Korea causes capital inflows to the Korean stock market to fluctuate. Second, we find that global investor sentiment about Korea causes foreign investors to modify their investments but not enough to induce rapid changes in capital inflows. Third, we show that positive sentiment about other Asia-Pacific countries causes foreign investors to invest more in Korean stock and bond markets. The results suggest that studies of global investor sentiment provide insight into determinants for international capital flows and have implications for capital flow management policies.