Miracle-dz/UniFAR-FTUs huggingface dataset:
A CPW fed X-Band antenna for satellite & radar applications

This paper presents the analysis of simple, compact, CPW- fed monopole aperture antenna with 10dB return loss (VSWR<;2) band from 8 GHz to 12GHz for X-band applications. The antenna includes ground plane, rectangular slot and a crossed rectangular exciting stub. The antenna is very simple and easy to fabricate. The proposed antenna is designed on an inexpensive FR4_Epoxy substrate with dielectric constant of εr =4.4 and with the size of 30mm×25mm×1.5mm The fundamental parameters of the antenna such as bandwidth return loss, radiation pattern, and gain are obtained All justifies the acceptable antenna standards. Simulation tool, based on the finite element method (HFSS V 13.0) has been used to analyze and optimize the proposed antenna Antenna is applicable for radar and satellite communication system It covers complete X-band (8-12) GHz and having the efficiency of 97%.
Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer

We extensively allelotyped a panel of 71 microdissected primary surgically resected non small cell lung cancer (NSCLC) tumors to identify chromosomal regions that are likely to contain tumor suppressor genes (TSGs) or associated with clinicopathologic and prognostic effects. Loss of heterozygosity (LOH) was detected by genotyping of 177 microsatellite markers and correlation of LOH with clinicopathologic parameters and prognosis was analyzed. Twenty markers showed an LOH frequency greater than 48%, and 8 of them (2p23.3, 2p24.3, 2q35, 6p22.2, 7p14.3, 7p22.2, 17q24.3 and 21q22.3) were novel in NSCLC. The high LOH regions were confirmed by further aligning continuous LOH regions from another set of 24 NSCLC tissues and defining 7 minimal deletion regions ranging from 1.29 to 12.26 cM. The aberrations of 8 markers showed a significant correlation with alteration of p16 and Rb proteins, suggesting the gene(s) located in the chromosomal loss that may interact with p16/Rb pathway. In addition, markers specifically associated with smoking, histology types and tumor stages were identified and the linked candidate TSGs were suggested. For example, marker D1S1612 closely linked with Mig‐6 gene was associated with smoking patients, squamous cell carcinoma patients and late‐stage patients. Furthermore, 3 markers, D2S2968, D6S2439 and D7S1818, were significantly associated with poor prognosis of NSCLC patients using both univariate and multivariate Cox's regression analyses (p = 0.035, 0.022 and 0.006, respectively). These markers can potentially be used for early lung cancer detection, outcome measurement and the positional cloning of new TSGs whose loss of function contributes to NSCLC tumorigenesis. © 2005 Wiley‐Liss, Inc.
Pronase Digestion of Carious Dentin

The aim of this study was to investigate the individual capabilities of the proteolytic enzyme preparation Pronase™, the enzyme collagenase and sodium hypochlorite to disintegrate and solubilize carious dentin. Samples of carious dentin, and samples of sound dentin for comparison, were extracted 4 times in succession for 24 h with buffered solutions of Pronase. Separate carious dentin samples were extracted in the same manner with buffered solutions of collagenase or with aqueous sodium hypochlorite. The extracts, the solid residues left over after the extractions and untreated samples of carious and sound dentin were digested with sulfuric acid–H2O2 and then analyzed for nitrogen content by a special adaptation of the Berthelot color reaction. Although Pronase did not attack sound dentin, it solubilized more than 90% of the nitrogen present in carious dentin. Collagenase solubilized approximately 66% of the nitrogen, whereas sodium hypochlorite released only 12–20% of the nitrogen of carious dentin. In clinical dentistry, chemical disintegration of carious dentin may reduce the need for mechanical removal of sound tooth structure.
Flexibility effects on the control system performance of large scale robotic manipulators

Structural flexibility of robotic manipulators becomes significant and limits the performance of a control system when manipulators are large structures, manipulating on large payloads, and/or operating at high speeds. The question of when a manipulator can be considered rigid or must be considered flexible is studied as a function of manipulator dynamics and task characteristics. Results are interpreted in simple quantitative forms which can be used as design and analysis tools to decide whether or not the manipulator flexibility will be a significant factor for a given task condition. The limitations imposed by the manipulator flexibility on the joint variable feedback control system performance is determined using linear and nonlinear methods. The closed loop eigenstructure behavior of finite dimensional models under joint variable feedback is studied and results are compared with the previously reported results.
CRFR1 is expressed on pancreatic β cells, promotes β cell proliferation, and potentiates insulin secretion in a glucose-dependent manner

Corticotropin-releasing factor (CRF), originally characterized as the principal neuroregulator of the hypothalamus-pituitary-adrenal axis, has broad central and peripheral distribution and actions. We demonstrate the presence of CRF receptor type 1 (CRFR1) on primary β cells and show that activation of pancreatic CRFR1 promotes insulin secretion, thus contributing to the restoration of normoglycemic equilibrium. Stimulation of pancreatic CRFR1 initiates a cAMP response that promotes insulin secretion in vitro and in vivo and leads to the phosphorylation of cAMP response element binding and the induction of the expression of several immediate-early genes. Thus, the insulinotropic actions of pancreatic CRFR1 oppose the activation of CRFR1 on anterior pituitary corticotropes, leading to the release of glucocorticoids that functionally antagonize the actions of insulin. Stimulation of the MIN6 insulinoma line and primary rat islets with CRF also activates the MAPK signaling cascade leading to rapid phosphorylation of Erk1/2 in response to CRFR1-selective ligands, which induce proliferation in primary rat neonatal β cells. Importantly, CRFR1 stimulates insulin secretion only during conditions of intermediate to high ambient glucose, and the CRFR1-dependent phosphorylation of Erk1/2 is greater with elevated glucose concentrations. This response is reminiscent of the actions of the incretins, which potentiate insulin secretion only during elevated glucose conditions. The presence of CRFR1 on β cells adds another layer of complexity to the intricate network of paracrine and autocrine factors and their cognate receptors whose coordinated efforts can dictate islet hormone output and regulate β cell proliferation.
Théorie L^p avec poids pour les équations d'Oseen dans des domaines non bornés

Cette these est consacree a l'analyse theorique des equations d'Oseen posees dans des regions non bornees. Le modele d'Oseen est une version linearisee des equations de Navier-Stokes decrivant un ecoulement de fluides visqueux incompressibles autour d'un obstacle borne. On choisit de poser le probleme dans un cadre fonctionnel faisant intervenir des poids anisotropes, qui permettent de decrire le comportement a l'infini des solutions et de tenir compte de la zone paraboloidale, appelee le sillage, apparaissant derriere l'obstacle durant l'ecoulement. Dans un premier temps, dans ce nouveau cadre, nous demontrons des resultats de densite et des inegalites de Hardy. Dans un deuxieme temps, nous montrons l'existence, l'unicite et la regularite de solutions. Les resultats sont d'abord etablis dans l'espace entier, puis dans un domaine exterieur.
Vérification formelle du respect de valeurs morales dans les SMA

L’utilisation croissante d’agents autonomes artiﬁciels dans des secteurs comme le milieu hospitalier ou les transports amene a reﬂechir au respect de regles morales partagees par tous. Le probleme est d’autant plus crucial que les regles morales informellement validees par tous sont souvent incompatibles les unes avec les autres, et que ce sont souvent des regles ethiques qui amenent l’humain, suivant les circonstances, a privilegier telle ou telle regle morale. Utiliser la preuve pour veriﬁer qu’un agent respecte bien des regles morales et ethiques pourraient aider a accroitre la conﬁance que nous pouvons avoir en de telles unites logicielles. Dans cet article, nous montrons, en nous appuyant sur une etude de cas, comment, a partir de regles morales a priori contradictoires mais ordonnees par des regles ethiques exprimant un systeme de valeurs, nous parvenons a deﬁnir un ensemble de proprietes formelles qui, lorsqu’elles sont etablies par un agent, permettent d’assurer que l’agent en question respecte bien la regle ethique souhaitee.
Giant Piezoresistance Measured in n-Type Nanothick Si Layer That Has Interface With $\hbox{SiO}_{2}$

A giant piezoresistive coefficient is, for the first time, experimentally measured for n-type nanothick silicon. Compared to n-type bulk silicon, the nanothick silicon resistors exhibit at least one order of magnitude higher piezoresistive coefficient. Based on 2-D quantum confinement effect, our theoretic calculation indicates that the piezoresistive sensitivity will decrease and approach to zero, along with continually thinning the n-type silicon resistor. Thus, quantum effect is not responsible for the giant piezoresistance of the n-type nanothick silicon. By phenomenon analysis and qualitative modeling, we attribute the obtained giant piezoresistance to stress-enhanced Si/SiO2 interfacial electron trapping effect. Hence, the giant piezoresistance in n-type nano thick silicon is dominantly originated from electron concentration change, instead of equivalent mobility change in conventional piezoresistance of bulk silicon.
A novel hardware accelerator guideline for ANN with high performance

Artificial Neural Network (ANN) is widely used in machine learning and artificial intelligence areas. But ANN requires a long running time and induces a high power consumption when running on a GPU or CPU which may hinder its application in embedded system. This paper proposes a hardware accelerator design guideline for ANN with arbitrary scales and depths. We take full consideration of the hardware scale, performance and power consumption.
MicroRNA-126–mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors

Lineage specification is thought to be largely regulated at the level of transcription, where lineage-specific transcription factors drive specific cell fates. MicroRNAs (miR), vital to many cell functions, act posttranscriptionally to decrease the expression of target mRNAs. MLL-AF4 acute lymphocytic leukemia exhibits both myeloid and B-cell surface markers, suggesting that the transformed cells are B-cell myeloid progenitor cells. Through gain- and loss-of-function experiments, we demonstrated that microRNA 126 (miR-126) drives B-cell myeloid biphenotypic leukemia differentiation toward B cells without changing expression of E2A immunoglobulin enhancer-binding factor E12/E47 (E2A), early B-cell factor 1 (EBF1), or paired box protein 5, which are critical transcription factors in B-lymphopoiesis. Similar induction of B-cell differentiation by miR-126 was observed in normal hematopoietic cells in vitro and in vivo in uncommitted murine c-Kit+Sca1+Lineage− cells, with insulin regulatory subunit-1 acting as a target of miR-126. Importantly, in EBF1-deficient hematopoietic progenitor cells, which fail to differentiate into B cells, miR-126 significantly up-regulated B220, and induced the expression of B-cell genes, including recombination activating genes-1/2 and CD79a/b. These data suggest that miR-126 can at least partly rescue B-cell development independently of EBF1. These experiments show that miR-126 regulates myeloid vs. B-cell fate through an alternative machinery, establishing the critical role of miRNAs in the lineage specification of multipotent mammalian cells.
Upper Bounds for the Selection of the Cryptographic Key Lifetimes: Bounding the Risk of Key Exposure in the Presence of Faults

With physical attacks threatening the security of current cryptographic schemes, no security policy can be developed without taking into account the physical nature of computation. In this article we first introduce the notion of Cryptographic Key Failure Tolerance, then we offer a framework for the determination of upper bounds to the key lifetimes for any cryptographic scheme used in the presence of faults, given a desired (negligible) error-bound to the risk of key exposure. Finally we emphasize the importance of choosing keys and designing schemes with good values of failure tolerance, and recommend minimal values for this metric. In fact, in standard environmental conditions, cryptographic keys that are especially susceptible to erroneous computations (e.g., RSA keys used with CRT-based implementations) are exposed with a probability greater than a standard error-bound (e.g., 2−40) after operational times shorter than one year, if the failurerate of the cryptographic infrastructure is greater than 1.04× 10−16 failures/hours.
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis.

Understanding the regulation of hepatic glucose metabolism had its foundation in the elucidation of several pathways, but recent advances have come from the application of molecular genetics. Five years ago little was known about the primary structure of the key regulatory enzymes. Since then, the primary sequence of liver GK, 6-PF-1-K, Fru-1,6-P2ase, PK, PEPCK, and 6-PF-2-K/Fru-2,6-P2ase have been derived from cDNA sequences and/or determined by direct protein sequencing. This has provided new insights into the molecular mechanisms of catalysis and the regulation of these enzymes by covalent modification. Isolation of the cDNAs for these enzymes also has allowed for the quantitation of specific mRNAs and permitted analysis of hormonal control of specific gene expression. The genes for these enzymes have been isolated and sequenced, and their promoter regions are being identified and characterized. Hormone response elements have been delineated in several of the promoters. The promoter regions for 6-PF-2-K/Fru-2,6-P2ase and Fru-1,6-P2ase have also been identified, and future research will focus on the elucidation of the mechanisms whereby hormones regulate the expression of these genes. A number of generalizations can be made about the regulation of gene expression of glycolytic/gluconeogenic enzymes. First, there is coordinate hormonal regulation of gene expression and these effects are consonant with their physiologic actions. Insulin induces the mRNAs that encode glycolytic enzymes and represses the mRNAs that encode gluconeogenic enzymes; cAMP has opposite effects. Both can increase or decrease transcription. Whereas insulin and cAMP affect all of these mRNAs, glucocorticoids appear to have a more restricted action. Second, transcriptional and posttranscriptional regulatory mechanisms are involved. The synthesis of all of the mRNAs discussed is regulated by hormones. Relatively little is known about how mRNA stability is regulated in general, but it is clear that PEPCK mRNA is stabilized by agents that increase the rate of transcription of the gene. Under appropriate metabolic signals this dual control of mRNA synthesis and stability provides for a long-term increase in PEPCK mRNA and protein. Studies with PK mRNA are less direct, but suggest a similar dual mechanism. It will be interesting to see whether multilevel regulation is restricted to these two mRNAs, both of which are involved in the same substrate cycle, or whether the stability of other mRNAs involved in hepatic glucose metabolism is also affected. Third, glucose appears to be important in the regulation of these hepatic genes. (ABSTRACT TRUNCATED AT 400 WORDS)
Ultra-short 25-nm-gate lattice-matched InAlAs/InGaAs HEMTs within the range of 400 GHz cutoff frequency

We have succeeded in fabricating ultra-short 25-nm-gate InAlAs/InGaAs high electron mobility transistors (HEMTs) lattice-matched to InP substrates. The two-step-recessed gate technology and low temperature processing at below 300/spl deg/C allowed the fabrication of such ultra-short gates. DC measurements showed that the 25-nm-gate HEMT had good pinchoff behavior. We obtained a cutoff frequency f/sub T/ of 396 GHz, within the range of 400 GHz f/sub T/, for the 25-nm-gate HEMT. This f/sub T/ is the highest value get reported for any type of transistor, and the gate length of 25 nm is the shortest value ever reported for any compound semiconductor transistor that exhibits device operation.
General Principles Chapter 1 Anatomical and physiological changes in pregnancy and their implications in clinical practice

Pregnancy is associated with profound anatomical, physiological, biochemical and endocrine changes that affect multiple organs and systems. These changes are essential to help the woman to adapt to the pregnant state and to aid fetal growth and survival. However, such anatomical and physiological changes may cause confusion during clinical examination of a pregnant woman. Similarly, changes in blood biochemistry during pregnancy may create difficulties in interpretation of results. Conversely, clinicians also need to recognise pathological deviations in these normal anatomical and physiological changes during pregnancy to institute appropriate action to improve maternal and fetal outcome.
New modeling techniques in multi-space CAD

This paper investigates new wavelet-based multiresolution modeling techniques in CAD. MRA techniques are extended to detail feature transplanting and detail feature copying from previous MRA editing including sweep editing, fractional editing, synthesis editing and detail blending. Two new editing methods called detail feature transplanting and detail feature copying are added to previous sweep editing, fractional editing, synthesis editing and detail blending. Detail feature transplanting editing is a way to transplant detail features of a curve/surface to another curve/surface. Detail feature copying editing is a way to copy or move detail features on the same curve/surface.
PV power conditioning system with LLC resonant converter in DCM

This paper presents a DC-DC power conditioning system for photovoltaic (PV) panels. A series loaded resonant converter with galvanic isolation, also known as an LLC resonant converter is used to interface PV arrays to the batteries within an energy management system. The LLC converter is operated in discontinuous conduction mode (DCM) in order to minimize the switching losses, even with the wide input voltage range. This mode of operation also makes LLC converters easy to parallel, which is desirable when multiple micro-converters are used instead of a centralized inverter. A perturb and observe maximum power point tracking (MPPT) algorithm is implemented with just a voltage sensor. Its performance is compared to that of an MPPT algorithm using both voltage and current feedback. In this paper the PV power conditioning system is designed and implemented in the laboratory. Experimental measurements demonstrate the power conditioning system functionality.
High accuracy surface modeling method combined with auxiliary variables for soil mapping

High accuracy surface modelling (HASM) is a spatial interpolation technique based on the fundamental theorem of surfaces, which can be applied to soil property interpolation. This study proposed modified HASM methods combined with ancillary variables for improved interpolation of soil properties. To evaluate the performance of HASM, we compared its performance with other classical methods such that ordinary kriging (OK), ordinary kriging combined geographic information (OK-Geo), stratified kriging (SK), and so on. To do so, predicted and measured values were compared using the mean error (ME), mean absolute error (MAE), root mean square error (RMSE) and prediction efficiency (PE). The results have shown that HASM generally performs better than the other methods with a lower estimation bias. Much more details were presented in the HASM maps for soil properties due to the combination of different types of geographic information which gave abrupt boundary for the spatial variation of soil properties.
Technology scaling: The CoolCubeTM paradigm

Scaling race towards aggressive nodes is getting more and more difficult as dimensions are getting close to the atoms ones. New solutions have to be investigated to find new ways of scaling while keeping the Moore's law benefits in terms of area, power, performance and cost. These solutions should leverage on existing technologies for reducing their development cost by proposing new usages. Also, as cost of designing complex systems explodes, these new technologies should come with design techniques close to existing ones without increasing their complexity. Finally, current technological issues such as increased complexity of Back-End-Of-Line (BEOL) with the successive delays of Extreme-Ultra-Violet lithography should be solved. This multi-dimensional problem makes candidates difficult to emerge. The sequential 3D CoolCubeTM technology is one of them: bringing very fine pitch 3D interconnects and leveraging on existing technologies, it's opening the door to real 3D-VLSI with the hope of reducing the actual pressure on BEOL while providing real 3D routing possibilities. However, many roadblock in terms of design still exist. In this paper, we show three aspects of design methodology showing its growing maturity and a PPA analysis based on this methodology showing that gains can meet the classical scaling requirements.
Soliton dynamics of hydrogen-bonded networks: A mechanism for proton conductivity.

The dynamics of protons in hydrogen-bonded quasi one-dimensional networks is described in terms of a diatomic lattice model with a doubly periodic on-site potential. The discrete system is reduced to a continuum double sine-Gordon equation for the protonic part plus an easily solvable differential equation for the heavy part. Its two-component kink solitons correspond to the ionic and Bjerrum defects. The correct response of these solitonic defects to an externally applied electric field makes this system a suitable model for qualitative and quantitative description of the protonic conductivity in hydrogen-bonded networks.
Power System State Estimation with Measurement Deficiency: An Observability/Measurement Placement Algorithm

Measurement system failures and modeling constraints may make it impossible for the power system state estimator to estimate bus voltage magnitudes and angles at every bus in the power system from the available real-time measurements. Such a measurement deficiency may be remedied by adding pseudo measurements of estimated bus loads. This paper presents a combined observability/measurement placement algorithm that both tests the measured network for observability and evaluates pseudo measurement sites as to the desirability of their inclusion into the measurement set.
Lysophosphatidic acid enhances collagen deposition and matrix thickening in engineered tissue

The time needed to produce engineered tissue is critical. A self‐assembly approach provided excellent results regarding biological functions and cell differentiation because it closely respected the microenvironment of cells. Nevertheless, the technique was time consuming for producing tissue equivalents with enough extracellular matrix to allow manipulations. Unlike L‐arginine supplementation that only increased accumulation of collagen in cell culture supernatant in our model, addition of lysophosphatidic acid, a natural bioactive lipid, did not modify the amount of accumulated collagen in the cell culture supernatant; however, it enhanced the matrix deposition rate without inducing fibroblast hyperproliferation and tissue fibrosis. Copyright © 2013 John Wiley & Sons, Ltd.