Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgeons' Perspective of a Newly Initiated Electronic Medical Record

The American Recovery and Reinvestment Act mandates “meaningful use” of an electronic health record (EHR) to receive current financial incentives and to avoid future financial penalties. Surgeons' ongoing adoption of an EHR nationally will be influenced by the early experiences of institutions that have made the transition from paper to electronic records. We conducted a survey to query surgeons at our institution regarding their perception of the EHR 3 months after institutional implementation. A total of 59 surveys were obtained from 24 senior staff and 35 residents. Results showed that surgeons believed the EHR was more effective as a billing tool than as a form of clinical documentation and believed the billing was more complete and accurate with the EHR. Surgeons also expressed concern that the EHR would negatively impact patient satisfaction, but in spite of this, they indicated that their personal quality of life was not negatively impacted.
Scalable System for Textual Analysis of Stock Market Prediction

—Stock Market Prediction is a problem that people deal with when they want to predict market trend. For short-term investment, news is one of the most important factors that has influence on stock price. Based on this idea, our target issue is to build a scalable stock market prediction system, which can process Chinese news articles in order to produce a prediction model. With this system, we can speed up the model training process and take into account more training source, e.g., posts from China’s microblog service, Sina Weibo. Also, with the emergence of cloud computing, a scalable system can lease more resources from cloud to serve the growing work. Our solution about building this system is using mature open source project, such as Hadoop for parallel computing, Mahout for scalable machine learning, and Jieba for Chinese text segmentation. We provide a basic algorithm for stock trend prediction, build the software stack, collect the news in Taiwan during March 2009 to May 2014 and also run some experiments to evaluate scalability of this system. The result shows that in this application, Jieba Chinese text Segmentation tool can scale well with multiprocessing, namely, 80 percent faster with four parallel processes compared to sequential mode. However, Mahout does not show significant speedup in this scenario.
Doing words together: assessing joint problem solving in a Scrabble task

Doing words together: assessing joint problem solving in a Scrabble task Riccardo Fusaroli Aarhus University, Aarhus, Denmark Svend Ostergaard Aarhus University, Aarhus, Denmark Joanna Raczaszek-Leonardi University of Warsaw (UW) Johanne Bjorndahl Aarhus University, Aarhus, Aarhus, Denmark Frederik Stjernfelt Copenhagen University Kristian Tyl´en Aarhus University, Aarhus, Aarhus, Denmark Abstract: In this paper we test the effects of social interactions in embodied problem solving by employing a Scrabble-like setting. 28 pairs of participants had to generate as many words as possible from 2 balanced sets of 7 letters, which they could manipulate, either individually or collectively. Collaborating makes pairs significantly more productive (M=68.7 SD=16.7) than the best of the two individuals alone (M=63.3, SD=19): F(1,28)=5.66, p=. 024, 2=. 17. Two parameters have a significant impact on the efficacy of collaboration: i)Pairs, whose performance is more similar in individual trials, gain higher benefit from collaboration: R(1,27)=-0.51, R2=. 26, p=. 005. ii)Pairs having the collective condition first perform better: F(1,28)=8.55, p=. 007, 2=. 23. This points to collaboration catalysing optimal solution strategies which can be used in the successive individual trial.
Efficient Security Solution for Privacy Cloud Services

In this paper, we exhibit a novel protection protecting security answer for cloud services. We manage client nameless access to cloud benefits and imparted stockpiling servers. Our answer furnishes enlisted clients with unacknowledged access to cloud services. Our answer offers unacknowledged verification. This implies that clients' close to home qualities (age, legitimate enrollment, fruitful installment) can be demonstrated without uncovering clients' character. Accordingly, clients can utilize services without any risk of profiling their conduct. Then again, if clients break supplier's tenets, their right to gain entrance rights are renounced. We dissect current security safeguarding answers for cloud services and layout our answer in light of cutting edge cryptographic segments. Our answer offers nameless access, unlinkability and the privacy of transmitted information. Also, we execute our answer and we yield the trial comes about and look at the execution with related arrangements.
Idiopathic intracranial hypertension

Objective: To determine the prevalence and nature of sinovenous obstruction in idiopathic intracranial hypertension (IIH) using auto-triggered elliptic-centric-ordered three-dimensional gadolinium-enhanced MR venography (ATECO MRV). Methods: In a prospective controlled study, 29 patients with established IIH as well as 59 control patients underwent ATECO MRV. In a randomized blinded fashion, three readers evaluated the images. Using a novel scoring system, each reader graded the degree of stenosis seen in the transverse and sigmoid sinuses of each patient. Results: There was excellent agreement across the three readers for application of the grading system. Substantial bilateral sinovenous stenoses were seen in 27 of 29 patients with IIH and in only 4 of 59 control patients. Conclusion: Using ATECO MRV and a novel grading system for quantifying sinovenous stenoses, the authors can identify IIH patients with sensitivity and specificity of 93%.
Propulsion of Microorganisms by Surface Distortions.

Swimming strategies of microorganisms must conform to the principles of self-propulsion at low Reynolds numbers. Here we relate the translational and rotational speeds to the surface motions of a swimmer and, for spheres, make evident novel constraints on mechanisms for propulsion. The results are applied to a cyanobacterium, an organism while motile mechanism is unknown, by considering incompressible streaming of the cell surface and oscillatory, tangential surface deformations. Finally, swimming efficiency using tangential motions is related to the surface velocities and a bound on the efficiency is obtained. {copyright} {ital 1996 The American Physical Society. }
Continuous performance test differences among schizophrenic out-patients living in high and low expressed emotion environments

Background. High expressed emotion (EE) in families reliably predicts relapse in schizophrenia leading to the assumption that high EE stresses patients and is the cause of relapse. Attempts at validating the stressful properties of high EE using autonomic skin conductance measures have been inconclusive. Since memory loaded vigilance tasks are sensitive to stress, we used a memory loaded version of the Continuous Performance Test (CPT) to see if test performance would change in the presence and absence of high or low EE relatives. If high EE was stressful, performance should decline in their presence of high EE relatives. If low EE was protective against stress performance should improve in the presence of low EE relatives. Methods. The CPT was administered to 41 schizophrenic and 51 normal control participants. CPT testing was conducted in the absence, then presence, then absence of high or low EE relatives. Results. Control participants had significantly greater CPT scores than schizophrenic participants; there was no effect of the relative's presence or absence on CPT performance for either the high or low EE group. Schizophrenic participants from high EE homes demonstrated significantly better, rather than worse, CPT scores than those in low EE homes. Conclusions. These findings fail to support the notion of high EE as stressor, but show that high EE and low EE patient groups perform a vigilance task significantly differently. We propose that patients from low EE groups may be underaroused relative to their high EE counterparts and that this underarousal leads to less than optimal performance on the CPT.
Dynamics of sine-Gordon solitons in the annular Josephson junction.

The annular Josephon junction allows for the study of undisturbed soliton (fluxon) motion in the absence of collisions. With new experimental methods and design we have realized for the first time a fully controllable way of introducing individual fluxons or antifluxons into such as system. This has allowed us to study multisoliton behavior and to make a comparison with existing soliton-chain perturbation theory. An unforseen crossover in the dynamical behavior at high velocities is tentatively interpreted in terms of soliton bunching
A non-comparative assessment of tolerability and efficacy of duloxetine in the treatment of depressed patients with Parkinson's disease

Objective: Depression is a comorbidity affecting quality of life (QoL) in patients with Parkinson's disease (PD) and requires appropriate treatment. This study evaluated the tolerability, safety, and efficacy of duloxetine 60 mg once daily for 12 weeks in PD patients with major depressive disorder (MDD). Research and design methods: Non-comparative, open-label, multi-center study. Main outcome measures: Tolerability was evaluated by discontinuation rate (acceptable if ≤ 19%) due to treatment-emergent adverse events (TEAEs) and motor symptoms (UPDRS). Safety measures were TEAEs, the UKU side effect rating scale, vital signs, weight, laboratory tests, and ECG. Efficacy measures included HAMD-17, BDI, CGI-S, PGI-I, and pain VAS. QoL was measured by PDQ-39. Results: Of the 151 patients enrolled, 8.6% (95% upper CI: 13.3%) discontinued the study due to TEAEs. Worsening in PD-related tremor and rigidity was not observed, activities of daily living significantly improved and UKU subscales progressively decreased. Clinically significant abnormalities in laboratory findings were limited to four cases of hypercholesterolemia and one increase of total bilirubin, CPK, and fasting glucose. Blood pressure, weight, and ECG did not change from baseline. HAMD-17 and PDQ-39 total score and individual domains, BDI, CGI-S, and PGI-I total scores significantly improved. Conclusions: Duloxetine seems well tolerated and likely effective in the treatment of depression associated with PD, with no detrimental effects in PD signs and symptoms.
Activity Spaces, Route Choices, and Neighborhoods: Assessing the Built Environment Associations with Walking Trips

Physical inactivity is one of the leading causes of the obesity epidemic. Bicycling and walking for transportation, also called active travel, is one strategy to address inactive lifestyles. There is growing evidence that supportive built environments can encourage active travel. The goal of this dissertation is to conduct an in-depth inquiry into walking and the built environment with three interrelated studies. The first study develops methods for assessing walkability within individual activity spaces: the geographic region accessible to an individual during a given walking trip. It uses three summary measures for walkability within activity spaces: i) the average walkability score across block segments (representing the general level of walkability in the activity space); ii) the standard deviation (representing the walkability variation), and; iii) the network autocorrelation (representing the spatial coherence of the walkability pattern). It assesses the method using data from an empirical study of built environment walkability and walking behavior in Salt Lake City, Utah, USA. It visualizes and maps these activity space summary measures to compare walkability among individuals’ trips within their neighborhoods. Results indicate that there is little match between walkability attribute summaries at Census geographies and summaries at activity spaces. This suggests Census geographies are not appropriate to summarize built environment
Antecedents of Social Innovation - Conceptual Model Proposition

In the last two decades, social entrepreneurship (SE) theory has become a broad and multifaceted stream of research. Social entrepreneurs approach social problems through novel ways, introducing innovative solutions that couple social capital and market instruments. Taken that innovation is considered by many the backbone of successful entrepreneurial ventures, the study of innovation in SE context is much needed to understand the distinctive features and origins of SE ventures. Social innovation profoundly changes the routines, resource combinations of the social system in which it occurs. Based on extensive literature review, this article aims to establish if, why and how, in given environmental and market contexts, social innovation occur. The study explores the building blocks and dynamics of social innovation in SE context. It starts with conceptualizations of social problems as sources of any social entrepreneurial venture. It then turns to the identification of necessary components of social innovation. The article presents an integrated process-based view of social innovation and its antecedents. The findings will hopefully lead to stretching the existing theory beyond an often-travelled path and allow the formulation of testable hypotheses.
The Ras/Protein Kinase A Pathway Acts in Parallel with the Mob2/Cbk1 Pathway To Effect Cell Cycle Progression and Proper Bud Site Selection

ABSTRACT In Saccharomyces cerevisiae, Ras proteins connect nutrient availability to cell growth through regulation of protein kinase A (PKA) activity. Ras proteins also have PKA-independent functions in mitosis and actin repolarization. We have found that mutations in MOB2 or CBK1 confer a slow-growth phenotype in a ras2Δ background. The slow-growth phenotype of mob2Δ ras2Δ cells results from a G1 delay that is accompanied by an increase in size, suggesting a G1/S role for Ras not previously described. In addition, mob2Δ strains have imprecise bud site selection, a defect exacerbated by deletion of RAS2. Mob2 and Cbk1 act to properly localize Ace2, a transcription factor that directs daughter cell-specific transcription of several genes. The growth and budding phenotypes of the double-deletion strains are Ace2 independent but are suppressed by overexpression of the PKA catalytic subunit, Tpk1. From these observations, we conclude that the PKA pathway and Mob2/Cbk1 act in parallel to determine bud site selection and promote cell cycle progression.
Predicting and Interpreting the Structure of Type IV Pilus of Electricigens by Molecular Dynamics Simulations

Nanowires that transfer electrons to extracellular acceptors are important in organic matter degradation and nutrient cycling in the environment. Geobacter pili of the group of Type IV pilus are regarded as nanowire-like biological structures. However, determination of the structure of pili remains challenging due to the insolubility of monomers, presence of surface appendages, heterogeneity of the assembly, and low-resolution of electron microscopy techniques. Our previous study provided a method to predict structures for Type IV pili. In this work, we improved on our previous method using molecular dynamics simulations to optimize structures of Neisseria gonorrhoeae (GC), Neisseria meningitidis and Geobacter uraniireducens pilus. Comparison between the predicted structures for GC and Neisseria meningitidis pilus and their native structures revealed that proposed method could predict Type IV pilus successfully. According to the predicted structures, the structural basis for conductivity in G.uraniireducens pili was attributed to the three N-terminal aromatic amino acids. The aromatics were interspersed within the regions of charged amino acids, which may influence the configuration of the aromatic contacts and the rate of electron transfer. These results will supplement experimental research into the mechanism of long-rang electron transport along pili of electricigens.
Low-frequency noise behavior of La-doped HfSiON/metal gate nMOSFETs

We investigate the low-frequency noise characteristics of HfSiON/metal gate nMOSFETs with and without La-doping and report new findings on the impact of La-doping on low-frequency noise of the nMOSFETs. The La-doped devices show lower noise intensity than the un-doped devices and it is attributed to the reduced trap density (Nt) and tunneling attenuation length (λ) caused by the La-doping. In the case of submicron devices, however, the La-doped devices show additional mobility-fluctuation noise at low-field condition and the additional noise intensity increases as the gate length decreases. These results indicate that the advantage of low noise of La-doping technique can decrease or even disappear in case of short-channel devices used for analog applications.
How does social sustainability feature in studies of supply chain management? A review and research agenda

Purpose The purpose of this paper is to examine how social sustainability is considered in the study of supply chain management, thereby identifying key areas for future researchers to develop. Design/methodology/approach A systematic literature review of 109 studies is conducted. The papers have been analysed with a particular focus on their definition of social sustainability, research methods used, the central themes covered and the evolution of the debate including theories and the main findings. Findings Findings show that, first, researchers have thus far focused on principles for managing social change, developing measures for performance, identifying drivers and barriers, with few studies considering the social practices, particularly at the micro level and in the context of small and medium-sized enterprises. Second, findings also reveal that there is less consideration of the suppliers’, as opposed to the buyers’, perspective. Research limitations/implications This review focuses only on social sustainability within supply chain management, without considering the economic and environmental dimensions. Practical implications This review provides the key themes and areas for managers/practitioners to consider when implementing social sustainability in supply chains. It also provides insights into under-researched areas together with the need for future researchers to move beyond frameworks and develop more tools and instruments for measuring social performance in practice. Originality/value This paper is one of the few studies that consider the social dimension of sustainability exclusively within the context of supply chains, providing insights and implications for further research.
Unfavorable effect of knee immobilization on Achilles tendon healing in rabbits

This study was undertaken to assess the effect of knee immobilization on the treatment of Achilles tendon rupture. After their Achilles tendons were severed, rabbits were divided into 2 groups. In Group A, only the ankle joint was immobilized. In Group B, both the knee and ankle joints were immobilized. At 4 weeks after surgery, both the ultimate tensile force and stiffness of the severed tendons were significantly greater in Group A than in Group B. In Group A, dense collagen fibers were seen in the repaired tendons, and the bundles of collagen fibers were parallel to one another along the axis of the tendons. In contrast, in Group B, dilated veins and capillaries were seen in the repaired tendons, and the proliferation of connective tissue containing collagen fibers was severely reduced around these veins and capillaries and was in general irregular and uneven. These results suggest that knee immobilization retards the healing of a ruptured Achilles tendon without suture, due to congestion and tension deprivation produced by keeping the tendon static.
Survey Analysis on the usage and Impact of Whatsapp Messenger

WhatsApp is a popular mobile application for providing instant messaging service in smartphones. It uses Internet services to communicate different type of text and multimedia messages between users or groups. Its users worldwide have crossed the figure of one billion in February 2016. The effect of WhatsApp on our lives, culture, and society keeps on increasing. It is also becoming popular tool for marketing in businesses and publicity in politics. This growth has also drawn the attention of researchers to understand the implications and effect of WhatsApp on its user’s social and personal life. We investigated the usage and effect of WhatsApp in the regions of Northern India. We performed an internet based survey using open-source Lime survey software and obtained responses. Total 460 responses had been received in which only 136 responses were considered for analysis those have completed all questions and having more than 18 years of age. The users in India made a slow shift from all social networking sites to WhatsApp in a quick span of time. This survey results show that there is a significant impact of WhatsApp on its users. Around 66% of WhatsApp users believe that WhatsApp has improved their relationship with friends. More than 63% of its users think it is not harmful for them. There are several other analyses presented in this paper based on age-groups and gender of WhatsApp users. This survey analysis may be useful for academicians and researchers for understanding the behavior of WhatsApp users and reflect the possibility of using WhatsApp in education, social services and governance.
Effects of the W153L Substitution in HIV Reverse Transcriptase on Viral Replication and Drug Resistance to Multiple Categories of Reverse Transcriptase Inhibitors

ABSTRACT A W153L substitution in HIV-1 reverse transcriptase (RT) was recently identified by selection with a novel nucleotide-competing RT inhibitor (NcRTI) termed compound A that is a member of the benzo[4,5]furo[3,2,d]pyrimidin-2-one NcRTI family of drugs. To investigate the impact of W153L, alone or in combination with the clinically relevant RT resistance substitutions K65R (change of Lys to Arg at position 65), M184I, K101E, K103N, E138K, and Y181C, on HIV-1 phenotypic susceptibility, viral replication, and RT enzymatic function, we generated recombinant RT enzymes and viruses containing each of these substitutions or various combinations of them. We found that W153L-containing viruses were impaired in viral replicative capacity and were hypersusceptible to tenofovir (TFV) while retaining susceptibility to most nonnucleoside RT inhibitors. The nucleoside 3TC retained potency against W153L-containing viruses but not when the M184I substitution was also present. W153L was also able to reverse the effects of the K65R substitution on resistance to TFV, and K65R conferred hypersusceptibility to compound A. Biochemical assays demonstrated that W153L alone or in combination with K65R, M184I, K101E, K103N, E138K, and Y181C impaired enzyme processivity and polymerization efficiency but did not diminish RNase H activity, providing mechanistic insights into the low replicative fitness associated with these substitutions. We show that the mechanism of the TFV hypersusceptibility conferred by W153L is mainly due to increased efficiency of TFV-diphosphate incorporation. These results demonstrate that compound A and/or derivatives thereof have the potential to be important antiretroviral agents that may be combined with tenofovir to achieve synergistic results.