Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparison of the changes in cardiac output and systemic vascular resistance during exercise following high-fat meals containing DHA or EPA

Long-chain n-3 PUFA can lower blood pressure (BP) but their acute effects on cardiac output, BP and systemic vascular resistance (SVR) in response to dynamic exercise are uncertain. We compared the effects of high-fat meals rich in EPA (20 : 5n-3), DHA (22 : 6n-3) or oleic acid (control) on cardiac output, BP and SVR in response to exercise stress testing. High-fat meals (50 g fat) containing high-oleic sunflower oil enriched with 4·7 g of either EPA or DHA v. control (high-oleic sunflower oil only) were fed to twenty-two healthy males using a randomised cross-over design. Resting measurements of cardiac output, heart rate and BP were made before and hourly over 5 h following the meal. A standardised 12 min exercise test was then conducted with further measurements made during and post-exercise. Blood samples were collected at fasting, 5 h postprandially and immediately post-exercise for the analysis of lipid, glucose and 8-isoprostane-F2α (8-iso-PGF2α). Plasma concentrations of EPA and DHA increased by 0·22 mmol/l 5 h following the EPA and DHA meals, respectively, compared with the control (P < 0·001). Resting cardiac output and 8-iso-PGF2α increased similarly following all meals and there were no significant differences in cardiac output during exercise between the meals. SVR was lower at 5 h and during exercise following the DHA but not EPA meal, compared with the control meal, by 4·9 % (95 % CI 1·3, 8·4; P < 0·01). Meals containing DHA appear to differ from EPA with regard to their effects on cardiovascular haemodynamics during exercise.
Pneumocystis jirovecii Pneumonia in AIDS Patients

Jose M. Varela1, Francisco J. Medrano1, Eduardo Dei-Cas2,3 and Enrique J. Calderon1 1Instituto de Biomedicina de Sevilla and CIBER de Epidemiologia y Salud Publica, Internal Medicine Service, Virgen del Rocio University Hospital. Seville, 2Parasitology-Mycology Service (EA4547), Centre of Biology Pathology, Lille-2 University Hospital Centre, Faculty of Medicine, Univ. Lille Nord de France, 3Biology & Diversity of Emerging Eukaryotic Pathogens, Institut Pasteur de Lille, Lille, 1Spain, 2,3France
Desarrollo de sistema Scada y análisis de controladores pi para la regulación de nivel en el tanque principal de la estación de mezcla IPA2

En septiembre de 2015, la espol inauguro el laboratorio de control de procesos industriales, para el cual se adquirio la planta de entrenamiento IPA26. Este equipo es una linea de envasado a escala, que se compone de una variedad de estaciones de produccion. Las estaciones van desde mezcla, hasta sellado y almacenamiento, entre otras. Una de las estaciones se denomina ipa2, la cual tiene por funcion exclusiva originalmente el proceso de mezcla entre dos tintas en un fluido base (agua). La programacion del controlador proporcionada por el fabricante de IPA2, para desempenar esta funcion, usa logica secuencial.
Matlab simscape simulation of an open voltage algorithm based maximum power point tracker for battery charging PV system

Currently, Photovoltaic (PV) energy is the most important energy resource in electrical power applications around the world since it is inexhaustible, clean and pollution free. As the output power from the PV arrays changing with solar irradiance and temperature, so it is necessary to operate the photovoltaic (PV) system at the maximum power point (MPP) to increase the power extraction from the solar panel. For this effective operation and maximum power extraction from a PV system, Maximum power point tracking (MPPT) algorithm plays a vital role by operating the PV energy system near the MPP. In this work, amongst several existing well established MPPT algorithms, the open voltage (OV) based algorithm is chosen for simulation of a PV system using Matlab / Simscape. As maximum power point (MPP) can be attained with a certain amount of load from the PV power system, so load matching is an important concept of MPPT algorithms. Here, the performances of this open voltage (OV) based algorithm method is evaluated for different values of solar radiation and battery was used as load to see the charging performance for the algorithm.
Shape from texture: the homogeneity hypothesis

The authors show how a maximum likelihood estimator can be constructed for homogeneous texture. The estimator turns out to be strikingly simple. It simply enforces, iteratively, coincidence of the centroid of the observed elements with the centroid of the imaging window. Whereas the estimator is based on first moments, error bounds are obtained, the authors show, from second moments. Experiments indicate that, for real textures, orientation estimates fall well inside predicted bounds. <<ETX>>
Role of strange quarks in quasielastic neutrino scattering.

Confirming our previous proposal, we show within a continuum random-phase approximation calculation that the ratio of proton-to-neutron neutrino-induced quasielastic yield is a sensitive way to determine the strange quark axial form factor of the nucleon. Particularly, we find that the ratio is virtually independent of final state interactions (accounted for by a finite-range force derived from the Bonn meson-exchange potential) and nuclear structure effects. We present the ratio calculated for the neutrino beam available in an experiment currently approved at LAMPF.
Repair of critical bone defects with injectable platelet rich plasma/bone marrow-derived stromal cells composite: experimental study in rabbits.

BACKGROUND Platelet-rich plasma (PRP) has been applied to promote bone healing and developed as a novel material for bone regeneration. This study aimed to investigate the feasibility of PRP carrier to deliver bone marrow derived stromal cells (BMSCs) and regenerate bone tissues to reconstruct critical bone defects in rabbits. METHODS Critical sized defect were made on eighteen rabbits' crania and treated by different composites: BMSCs/PRP (n=6); Autogenous particulate cancellous bone group (n=6) and PRP alone group (n=6). The defects were evaluated by gross observation, radiographic examination, histological examination, and mechanical examination at 12 weeks postoperatively. RESULTS The results showed that repair of bone defect was the least in PRP alone group, and significant new bone formation could be observed in BMSCs/PRP group and particulate cancellous bone group, radiopacity area in BMSCs/PRP group attained 76.5%, which was in the same range of that in autogenous particulate cancellous bone group (82.4% in radiopacity area), compressive strength of engineered bone in BMSCs/PRP group attained 71% of that in autogenous particulate cancellous bone group (p<0.05). CONCLUSION These data implicated that BMSCs delivered from PRP gel can repair bony defect in immunocompetent animals, and the tissue engineered bone in BMSCs/PRP group is comparable to autogenous particulate cancellous bone group for the repair of critical-sized bone defect.
Membrane Proteins in Human Neutrophils - Identification and Characterization of Lipid Rafts in Subcellular Organelles

The human neutrophil is an important effector cell in acute inflammation and in the innate immune response against bacteria and fungi. When immune reactions occur in the tissue in response to antigen challenge, neutrophils are the first cells to enter the site of inflammation. The neutrophil is equipped with a vast amount of receptors that both interact with inflammatory mediators and host tissue as well as with the prey. These receptors are found on the cell surface but are also stored in different types of granules and vesicles in the cell. By mobilizing the granules and vesicles to various extents and thereby upregulate receptors to the plasma membrane, the mature neutrophil can modulate its communication with the environment. One granule type, the azurophil granules, primarily delivers a killing machinery to intracellular organelles containing a prey that has been engulfed. These granules have traditionally been regarded as classical lysosomes, but their membrane is so far largely uncharacterized. The aim of this thesis was to elucidate details regarding azurophil granule membrane composition in order to further understand their role in neutrophil function. The studies led to identification of so-called lipid rafts in the azurophil and other granule membranes, and a detailed characterization of the azurophil granule lipid rafts with regard to protein composition was thus performed. One of the proteins identified in azurophil granule membranes was stomatin. This protein was present also in other granule/vesicle membranes and the plasma membrane. Furthermore, the protein was localized to lipid rafts. Apart from stomatin, the azurophil granule membrane rafts contained a vast number of proteins, of possible importance for membrane structure/integrity and fusion. The fact that several cytoskeletal proteins also were identified, suggests that the granule membrane is organized in much the same way as the plasma membrane. The thesis also includes studies on the neutrophil receptors for galectin-3, a potent activator of extravasated human neutrophils. Since granule mobilization is a prerequisite for galectin-3-induced activation of the cells, the receptors have been suggested to be granule localized. Here, galectin-3-binding proteins from specific/gelatinase granules were isolated, and among these, CD66a and CD66b were identified as the most plausible receptor candidates. The CD66b is a glycophosphatidyl inositol (GPI)-linked protein that was found to be localized to lipid rafts, suggesting that raft-associated signaling may be of importance for the galectin-3-induced neutrophil responses. 91-628-6953-1 978-91-628-6953-1
Safety and Tolerability of the Lidocaine Patch 5%, a Targeted Peripheral Analgesic: A Review of the Literature

The safety, tolerability, and efficacy of the lidocaine patch 5% (Lidoderm®), a targeted peripheral analgesic with an FDA‐approved indication for the treatment of postherpetic neuralgia, has been well established. Recent case reports and studies have suggested potential efficacy in other neuropathic and nonneuropathic pain conditions. Several pharmacokinetic studies have demonstrated minimal systemic absorption with 12‐, 18‐, and 24‐hour/day dosing. Mean maximum plasma concentrations have shown the lidocaine patch to possess a minimal risk for systemic toxicities or drug‐drug interactions. The most common adverse events generally involve mild skin reactions. There have been no drug‐drug interactions noted in clinical trials. Recent evidence suggests that extended application does not result in A‐β‐mediated sensory loss at the application site, which is particularly important in patients who already have a degree of sensory loss due to their underlying condition. The lidocaine patch provides a treatment option that carries a relatively low systemic adverse event and drug‐drug interaction risk burden, even with continuous application of up to four patches per day.
Magnetic field environments at power frequency inside modern buildings

This paper presents the results of indoor ELF magnetic field environments measured for three kinds of place (home, office, and school) using various electrical devices. Both the fields emitted by devices in isolation and in composite environments were measured. For composite environments, measurements were made with a distance interval of 0.5 m in grids at heights of 0.3 m, 1 m and 1.5 m above the floor ground respectively. It was found that the magnetic field environment in a typical home is the worst and that in school classroom is the best. This is understandable as many electric appliances are used in a home, while few electric appliances are used in a classroom. For devices in isolation, the measurements were made with an interval of 0.05 m so that the field strength versus distance from the source can be found. Results show that the magnetic fields at close proximity could reach as high as 36 μT, 14 μT and 3.2 μT for the exhaust fan in kitchen, LCD TV set in living room, and desktop computer and typing machine in office, respectively. In general, the magnetic field strength decayed rapidly to less than 0.2 μT at 1 m away from the power unit of the device.
Energy Levels and Metabolizable Energy : Protein Ratio for Male Broiler Chicks from 22 to 42 Days of Age

Levels of metabolizable energy (ME) of 2,900, 3,100 and 3,300 kcal and energy to protein ratio (EM: PB) of 128, 148, 168 and 188 kcal/%CP were evaluated with male broiler chicks from 22 to 42 days of age, assigned to a completely randomized 3 x 4 factorial design, where each treatment had four replications of 18 birds. Increasing the ME: CP ratio resulted in linear decreasing effect on feed intake, live weight, weight gain, crude protein intake, energy intake, carcass weight, breast meat weight, drumsticks weight and linearly increased abdominal fat percentage within each level of energy. The 148 ME:CP ratio (20,95% CP) in the level of 3100 kcal ME met the broilers requirements to optimum growth from 22 to 42 days of age, while 188 ME:CP ratio was inadequate. Because of the high costs, decreasing EM: PB ratio must be evaluated to optimize a production system where the carcass quality is also considered.
Prospect and discussion on the relay system configuration of intelligent substation

The technical characteristic of smart grid is the realization of Information, digitization, automation and interaction. The relay equipments of intelligent substation are important components of smart grid, under the “four basic requirements of qualities” (sensitivity, selectivity, speed and reliability), its configuration is divided into two layers: process level and substation level. The process level is individually to set the protection configuration according to the primary equipments, and it can be placed near the primary equipments. In the end it will unit with the primary equipments together as one, and the protection will adopts distributed configuration; the substation level will be equipped with centralized back-up protection, which adopts self-adaptive and on-line real-time self-tuning technology.
Foreground Detection Utilizing Structured Sparse Model via l1,2 Mixed Norms

Foreground object detection is a crucial technique of intelligent surveillance systems, and it is still a challenging problem in complex scenes with illumination variations and dynamic backgrounds. Intuitively, the foreground object pixels are often not sparsely distributed but tend to be clustered. Motivated by this hypothesis, we present a new structured sparse model to extract foreground objects, which introduces the spatial neighborhood information into a unified optimization framework by l1,2 mixed norms. Simultaneously, we also give the solving method of the proposed model in details. Moreover, we apply the model to the sparse signal recovery and background subtraction in videos. In the experiments, better performance is obtained over previous methods. The experimental results validate the hypothesis and the effectiveness of the proposed method.
Persistent migration of neuroblasts from the subventricular zone to the injured striatum mediated by osteopontin following intracerebral hemorrhage

We investigated intracerebral hemorrhage (ICH)‐induced lateral migration of neuroblasts and the mechanism underlying this migration. ICH model was induced by collagenase injection into the striatum of adult wild‐type and osteopontin (OPN) knockout mice. In the wild‐type mice, the lateral migration of neuroblasts from the ipsislateral subventricular zone (SVZ) towards the hematoma started at day 3 and continued up to day 28 after ICH. In addition to migrating towards the hematoma, neuroblasts also migrated to the area of ipsilateral striatum remote to the hematoma. The migrating neuroblasts were closely associated with activated astrocytes and blood vessels in the injured striatum. Following ICH, the expression of OPN was up‐regulated in the ipsilateral striatum from day 1 to day 28. In vitro, OPN treatment did not affect the proliferation of neural progenitors, but enhanced the trans‐well and radial migration of neural progenitors. In vivo, OPN deficiency did not affect the proliferation of neural progenitors in the SVZ. However, following ICH a significant decrease in lateral neuroblast migration was observed in the OPN knockout mice compared with the wild‐type mice. These results suggest that increased OPN expression in the injured striatum plays a significant role in the lateral migration of neuroblasts following ICH.
Hystérésis magnétique sous contraintes mécaniques : modèle de loi de comportement adapté à la simulation de structures

Au cœur des dispositifs electromagnetiques, les materiaux magnetiques sont de plus en plus souvent soumis a des chargements magneto-mecaniques multiaxiaux complexes. Le dimensionnement et l'optimisation des dispositifs necessitent donc la mise en œuvre de modeles capables de rendre compte de ce comportement. En particulier, la representation de l'hysteresis magnetique est cruciale lors de l'evaluation des pertes. En nous basant sur la version vectorielle du modele de Jiles-Atherton, nous proposons d'introduire les effets magneto-mecaniques en utilisant une approche multi-echelle anhysteretique. Le modele permet de decrire raisonnablement l'evolution de la permeabilite, du champ coercitif et des pertes par hysteresis des materiaux soumis a des chargements magneto-mecaniques. Ce modele est ensuite associe a la methode des elements finis pour evaluer l'effet des contraintes d'assemblage sur les pertes par hysteresis dans le rotor d'une machine a reluctance variable.
MixGF: Spectral Probabilities for Mixture Spectra from more than One Peptide*

In large-scale proteomic experiments, multiple peptide precursors are often cofragmented simultaneously in the same mixture tandem mass (MS/MS) spectrum. These spectra tend to elude current computational tools because of the ubiquitous assumption that each spectrum is generated from only one peptide. Therefore, tools that consider multiple peptide matches to each MS/MS spectrum can potentially improve the relatively low spectrum identification rate often observed in proteomics experiments. More importantly, data independent acquisition protocols promoting the cofragmentation of multiple precursors are emerging as alternative methods that can greatly improve the throughput of peptide identifications but their success also depends on the availability of algorithms to identify multiple peptides from each MS/MS spectrum. Here we address a fundamental question in the identification of mixture MS/MS spectra: determining the statistical significance of multiple peptides matched to a given MS/MS spectrum. We propose the MixGF generating function model to rigorously compute the statistical significance of peptide identifications for mixture spectra and show that this approach improves the sensitivity of current mixture spectra database search tools by a ≈30–390%. Analysis of multiple data sets with MixGF reveals that in complex biological samples the number of identified mixture spectra can be as high as 20% of all the identified spectra and the number of unique peptides identified only in mixture spectra can be up to 35.4% of those identified in single-peptide spectra.
BASES TEÓRICAS PARA LA ELABORACIÓN DE UN PROGRAMA EDUCATIVO DE INTERVENCIÓN PSICOMOTRIZ EN NIÑOS CON TDAH

El Trastorno por Deficit de Atencion con Hiperactividad (TDAH) tiene importantes repercusiones psicosociales y es una de las principales causas de fracaso escolar. Tanto su diagnostico como su tratamiento farmacologico se han incrementado notablemente en los ultimos anos por lo que diversos organismos internacionales han aconsejado que las intervenciones conductuales y educativas sean las medidas principales en este trastorno. Los ninos con TDAH deben ser atendidos en una escuela inclusiva que permita responder a las necesidades de todos los alumnos. El concepto de psicomotricidad como tecnica educativa o terapeutica esta muy cercano a los principios de la educacion inclusiva. La psicomotricidad pretende el desarrollo o el restablecimiento de las capacidades del nino, no solo de las psicomotoras sino tambien de las cognitivas, afectivas y sociales, utilizando para ello el cuerpo y sus movimientos. En este trabajo de revision teorica se justifica el uso de la psicomotricidad en el TDAH, sobre todo por las alteraciones en las habilidades psicomotoras que presentan muchos de estos ninos, y se proporcionan las bases teoricas para la elaboracion de un programa educativo de intervencion psicomotriz en ninos con este trastorno, junto con los objetivos psicomotores, cognitivos, afectivos y comunicativos de un programa de estas caracteristicas, asi como la metodologia de intervencion psicomotriz.
Polycistronic viral vectors.

Traditionally, vectors for gene transfer/therapy experiments were mono- or bicistronic. In the latter case, vectors express the gene of interest coupled with a marker gene. An increasing demand for more complex polycistronic vectors has arisen in recent years to obtain complex gene transfer/therapy effects. In particular, this demand is stimulated by the hope of a more powerful effect from combined gene therapy than from single gene therapy in a process whose parallels lie in the multi-drug combined therapies for cancer or AIDS. In the 1980's we had only splicing signals and internal promoters to construct such vectors: now a new set of biotechnological tools enables us to design new and more reliable bicistronic and polycistronic vectors. This article focuses on the description and comparison of the strategies for co-expression of two genes in bicistronic vectors, from the oldest to the more recently described: internal promoters, splicing, reinitiation, IRES, self-processing peptides (e.g. foot-and-mouth disease virus 2A), proteolytic cleavable sites (e.g. fusagen) and fusion of genes. I propose a classification of these strategies based upon either the use of multiple transcripts (with transcriptional mechanisms), or single transcripts (using translational/post-translational mechanisms). I also examine the different attempts to utilize these strategies in the construction of polycistronic vectors and the main problems encountered. Several potential uses of these polycistronic vectors, both in basic research and in therapy-focused applications, are discussed. The importance of the study of viral gene expression strategies and the need to transfer this knowledge to vector design is highlighted.
Wiener LMS Channel Estimation and Tracking Algorithm for OFDM Systems with Transmitter Diversity

A Wiener LMS channel estimation and tracking algorithm for OFDM systems with transmitter diversity was proposed. The algorithm used Wiener prediction technology to improve the ability of tracking channel. The simulation results show that the algorithm achieved reliable channel estimation. The performance is improved greatly compared with conventional algorithm LMS algorithm and decision directed algorithm proposed by LiYe and this improvement is obvious under fast varying channel
Low Voltage Design Techniques and Considerations for Integrated Operational Amplifier Circuits

The pertinent literature on low voltage Operational Amplifiers is surveyed and techniques suitable for operation at low power supply voltages are identified. Designs implemented in standard Bipolar, BiCMOS, and CMOS technologies are classified and characterized. The lower limit of the power supply voltage is identified as well as the performance tradeoffs that are sacrificed as that limit is approached. The three aforementioned technologies are compared quantitatively and qualitatively.