Miracle-dz/UniFAR-FTUs huggingface dataset:
THE 2012 RISE OF THE REMARKABLE TYPE IIn SN 2009ip

Recent observations by Mauerhan et al. have shown the unprecedented transition of the previously identified luminous blue variable (LBV) and supernova (SN) impostor SN 2009ip to a real Type IIn SN explosion. We present ∼100 optical R- and I-band photometric measurements of SN 2009ip obtained between UT 2012 September 23.6 and October 9.6, using 0.3–0.4 m aperture telescopes from the Coral Towers Observatory in Cairns, Australia. The light curves show well-defined phases, including very rapid brightening early on (0.5 mag in 6 hr observed during the night of September 24), a transition to a much slower rise between September 25 and September 28, and a plateau/peak around October 7. These changes are coincident with the reported spectroscopic changes that most likely mark the start of a strong interaction between the fast SN ejecta and a dense circumstellar medium formed during the LBV eruptions observed in recent years. In the 16-day observing period, SN 2009ip brightened by 3.7 mag from I = 17.4 mag on September 23.6 (MI ≃ −14.2) to I = 13.7 mag (MI ≃ −17.9) on October 9.6, radiating ∼3 × 1049 erg in the optical wavelength range. As of 2012 October 9.6, SN 2009ip is more luminous than most Type IIP SN and comparable to other Type IIn SN.
Stability Versus Maneuverability in Aquatic Locomotion1

Abstract The dictionary definition of stability as “Firmly established, not easily to be changed” immediately indicates the conflict between stability and maneuverability in aquatic locomotion. The present paper addresses several issues resulting from these opposing requirements. Classical stability theory for bodies moving in fluids is based on developments in submarine and airship motions. These have lateral symmetry, in common with most animals. This enables the separation of the equations of motion into two sets of 3 each. The vertical (longitudinal) set, which includes motions in the axial (surge), normal (heave) and pitching directions, can thus be separated from the lateral-horizontal plane which includes yaw, roll and sideslip motions. This has been found useful in the past for longitudinal stability studies based on coasting configurations but is not applicable to the analysis of turning, fast starts and vigorous swimming, where the lateral symmetry of the fish body is broken by bending motions. The present paper will also examine some of the aspects of the stability vs. maneuverability tradeoff for these asymmetric motions. An analysis of the conditions under which the separation of equations of motions into vertical and horizontal planes is justified, and a definition of the equations to be used in cases where this separation is not accurate enough is presented.
[Assessing and predicting recovery from a coma following traumatic brain injury: contribution of neuroradiological data].

OBJECTIVE Literature review concerning the contribution of neurological imaging to the assessment of traumatic lesions and the prognosis of traumatic coma. MATERIAL AND METHODS Interrogation of scientific databases Medline, Embase and Current Contents via key-words. One hundred and seventy-one articles were picked up out of which 67 were analysed according to the French ANAES' rules. Results and discussion are drawn from the literature data and the author's experience. RESULTS AND DISCUSSION In the acute stage the diagnosis approach prevails the prognostic dimension, is confused by secondary complications. Computerized-Tomography (CT) remains the best imaging modality, allowing a quick diagnosis of most of injuries, especially those which require an emergency treatment. But its predictive value in coma outcome is low. Although magnetic resonance imagery (MRI) is more sensitive, it does not at the acute stage lead to therapeutic modifications, increases the costs and is thus not necessary. MRI angiography may show cranial vessel injury which need specific therapeutic procedures. In the subacute or chronic stage after a severe head injury, CT is useful for the follow up and may provide some prognostic informations. But MRI with classical sequences has a higher sensitive and predictive power. Diffusion weighted imaging has not so far made the proof of it's predictive value. Proton MR spectroscopy seems to be able to provide data correlated with neurological outcome (NAA/Cr), but is not of routine use. Single-photon emission tomography is also useful to assess brain injury sequelae in the chronic stage; positron-emission tomography still remains a research technology. These 2 modalities have not yet a prognostic value. CONCLUSION In the acute stage CT remains the best imaging modality. In the subacute and chronic stage MRI has the highest predictive power. Special sequences raise new hopes. Single-photon emission tomography and positron-emission tomography have not yet a prognostic value.
Phase I/II study of resection and intraoperative cesium-131 radioisotope brachytherapy in patients with newly diagnosed brain metastases.

OBJECT Resected brain metastases have a high rate of local recurrence without adjuvant therapy. Adjuvant whole-brain radiotherapy (WBRT) remains the standard of care with a local control rate > 90%. However, WBRT is delivered over 10-15 days, which can delay other therapy and is associated with acute and long-term toxicities. Permanent cesium-131 ((131)Cs) implants can be used at the time of metastatic resection, thereby avoiding the need for any additional therapy. The authors evaluated the safety, feasibility, and efficacy of a novel therapeutic approach with permanent (131)Cs brachytherapy at the resection for brain metastases. METHODS After institutional review board approval was obtained, 24 patients with a newly diagnosed metastasis to the brain were accrued to a prospective protocol between 2010 and 2012. There were 10 frontal, 7 parietal, 4 cerebellar, 2 occipital, and 1 temporal metastases. Histology included lung cancer (16), breast cancer (2), kidney cancer (2), melanoma (2), colon cancer (1), and cervical cancer (1). Stranded (131)Cs seeds were placed as permanent volume implants. The prescription dose was 80 Gy at a 5-mm depth from the resection cavity surface. Distant metastases were treated with stereotactic radiosurgery (SRS) or WBRT, depending on the number of lesions. The primary end point was local (resection cavity) freedom from progression (FFP). Secondary end points included regional FFP, distant FFP, median survival, overall survival (OS), and toxicity. RESULTS The median follow-up was 19.3 months (range 12.89-29.57 months). The median age was 65 years (range 45-84 years). The median size of resected tumor was 2.7 cm (range 1.5-5.5 cm), and the median volume of resected tumor was 10.31 cm(3) (range 1.77-87.11 cm(3)). The median number of seeds used was 12 (range 4-35), with a median activity of 3.82 mCi per seed (range 3.31-4.83 mCi) and total activity of 46.91 mCi (range 15.31-130.70 mCi). Local FFP was 100%. There was 1 adjacent leptomeningeal recurrence, resulting in a 1-year regional FFP of 93.8% (95% CI 63.2%-99.1%). One-year distant FFP was 48.4% (95% CI 26.3%-67.4%). Median OS was 9.9 months (95% CI 4.8 months, upper limit not estimated) and 1-year OS was 50.0% (95% CI 29.1%-67.8%). Complications included CSF leak (1), seizure (1), and infection (1). There was no radiation necrosis. CONCLUSIONS The use of postresection permanent (131)Cs brachytherapy implants resulted in no local recurrences and no radiation necrosis. This treatment was safe, well tolerated, and convenient for patients, resulting in a short radiation treatment course, high response rate, and minimal toxicity. These findings merit further study with a multicenter trial.
Enhanced Slotted Aloha Protocols for Underwater Sensor Networks with Large Propagation Delay

Recently underwater sensor networks (UWSN) attracted large research interests. Medium access control (MAC) is one of the major challenges faced by UWSN due to the large propagation delay and narrow channel bandwidth of acoustic communications used for UWSN. Widely used slotted aloha (S-Aloha) protocol suffers large performance loss in UWSNs, which can only achieve performance close to pure aloha (PAloha). In this paper we theoretically model the performances of S-Aloha and P-Aloha protocols and analyze the adverse impact of propagation delay. According to the observation on the performances of S-Aloha protocol we propose two enhanced S-Aloha protocols in order to minimize the adverse impact of propagation delay on S-Aloha protocol. The first enhancement is a synchronized arrival S-Aloha (SA-Aloha) protocol, in which frames are transmitted at carefully calculated time to align the frame arrival time with the start of time slots. Propagation delay is taken into consideration in the calculation of transmit time. As estimation error on propagation delay may exist and can affect network performance, an improved SA-Aloha (denoted by ISAAloha) is proposed, which adjusts the slot size according to the range of delay estimation errors. Simulation results show that both SA-Aloha and ISA-Aloha perform remarkably better than S-Aloha and P-Aloha for UWSN, and ISA-Aloha is more robust even when the propagation delay estimation error is large.
DOES BATEMAN'S PRINCIPLE APPLY TO BROADCAST‐SPAWNING ORGANISMS? EGG TRAITS INFLUENCE IN SITU FERTILIZATION RATES AMONG CONGENERIC SEA URCHINS

Evolutionary biologists generally invoke male competition and female choice as mechanisms driving sexual selection. However, in broadcast‐spawning organisms sperm may be limiting and females may compete, in the Darwinian sense, for increased mating success. In this study, I investigate how species differences in egg and sperm traits result in different patterns of fertilization among three closely related sea urchins (Strongylocentrotus purpuratus, S. franciscanus, and S. droebachiensis). Field studies demonstrate that all three species achieve similar percentages of eggs fertilized when eggs and sperm are released simultaneously. However, when sperm must disperse before encountering eggs, differences arise among species such that those with the smaller eggs and faster but shorter‐lived sperm achieve relatively fewer fertilizations than do species with larger eggs and slower but longer‐lived sperm. A field hybridization experiment, field estimates of sperm dispersal, correlations of egg size to field rates of fertilization, laboratory studies of fertilization kinetics, and a simulation model all suggest that it is attributes of the egg (probably egg size) that are responsible for the differences. These patterns of fertilization match the species' patterns of dispersion; species that do well only when sperm and eggs are released in close proximity are more aggregated, species that do relatively well when sperm and eggs are released farther apart are more dispersed. These results are consistent with the notion that eggs of different species are adapted to maximize reproductive success under different degrees of sperm limitation and suggest that male competition and female choice may not be an appropriate dichotomy in broadcast‐spawning organisms.
Ein neues Leitbild für Unternehmen

In der Industrial Ecology wird das Ziel verfolgt, industrielle Systeme nach dem Vorbild der Natur als industrielle Okosysteme zu gestalten. Die leitbildhafte Orientierung verspricht Unternehmen Zukunftsfahigkeit. Dabei geht es um eine resiliente Ressourcenwirtschaft, die Nutzung von Null-Emissionstechniken und die Ausschopfung uberbetrieblicher Synergien.
University-Affiliated Alcohol Marketing Enhances the Incentive Salience of Alcohol Cues

We tested whether affiliating beer brands with universities enhances the incentive salience of those brands for underage drinkers. In Study 1, 128 undergraduates viewed beer cues while event-related potentials (ERPs) were recorded. Results showed that beer cues paired with in-group backgrounds (logos for students’ universities) evoked an enhanced P3 ERP component, a neural index of incentive salience. This effect varied according to students’ levels of identification with their university, and the amplitude of the P3 response prospectively predicted alcohol use over 1 month. In Study 2 (N = 104), we used a naturalistic advertisement exposure to experimentally create in-group brand associations and found that this manipulation caused an increase in the incentive salience of the beer brand. These data provide the first evidence that marketing beer via affiliating it with students’ universities enhances the incentive salience of the brand for underage students and that this effect has implications for their alcohol involvement.
Functional Characterization of a Eukaryotic Melibiose Transporter1[OA]

Pathogenic fungi drastically affect plant health and cause significant losses in crop yield and quality. In spite of their impact, little is known about the carbon sources used by these fungi in planta and about the fungal transporters importing sugars from the plant-fungus interface. Here, we report on the identification and characterization of MELIBIOSE TRANSPORTER1 (MBT1) from the hemibiotrophic fungus Colletotrichum graminicola (teleomorph Glomerella graminicola), the causal agent of leaf anthracnose and stalk rot disease in maize (Zea mays). Functional characterization of the MBT1 protein in baker’s yeast (Saccharomyces cerevisiae) expressing the MBT1 cDNA revealed that α-d-galactopyranosyl compounds such as melibiose, galactinol, and raffinose are substrates of MBT1, with melibiose most likely being the preferred substrate. α-d-Glucopyranosyl disaccharides like trehalose, isomaltose, or maltose are also accepted by MBT1, although with lower affinities. The MBT1 gene shows low and comparable expression levels in axenically grown C. graminicola and upon infection of maize leaves both during the initial biotrophic development of the fungus and during the subsequent necrotrophic phase. Despite these low levels of MBT1 expression, the MBT1 protein allows efficient growth of C. graminicola on melibiose as sole carbon source in axenic cultures. Although Δmbt1 mutants are unable to grow on melibiose, they do not show virulence defects on maize.
Is the identification of the external branch of the superior laryngeal nerve mandatory in thyroid operation? Results of a prospective randomized study.

BACKGROUND The aim of this study was to investigate the incidence of injury to the external branch of the superior laryngeal nerve (EBSLN) with 2 different surgical approaches. METHODS From 1998 to 2000, 289 consecutive patients undergoing thyroidectomy were randomly divided into 2 groups. In group A (137 patients [215 upper pole ligations]), the superior thyroid artery was ligated after identification of the EBSLN. In group B (152 patients [244 upper pole ligations]), the superior thyroid artery's branches were ligated separately close to the gland. In all patients, a phoniatric evaluation with videostrobolaryngoscopy and spectrographic examination was performed. RESULTS The 2 groups were well matched regarding age, sex, thyroid pathological findings, and type of operation. In group A, the EBSLN was not clearly identified in 11.6% of cases. Alterations of EBSLN function were absent in both groups of patients, either postoperatively or 1 and 6 months after operation. Group B showed statistically significant shorter operative time compared with that for group A. CONCLUSIONS Even if the EBSLN often crosses the superior thyroid pedicle, especially in large goiters, this study demonstrated that accurate distal ligation of the branches of the superior thyroid artery is a safe technique to prevent EBSLN injury.
Probability of Negative Mycobacterium tuberculosis Complex Cultures Based on Time to Detection of Positive Cultures: a Multicenter Evaluation of Commercial-Broth-Based Culture Systems

ABSTRACT We conducted a multicenter study to determine whether Mycobacterium tuberculosis complex (MTBC) cultures in automated broth-based systems could reliably be considered negative sooner than 6 weeks. Laboratory sites used Bactec MGIT or BacT/Alert and tracked results of time to detection of all mycobacteria (TTD-all, n = 1547) and of MTBC (TTD-MTBC, n = 466) over 6-month periods from primarily (93%) respiratory specimens. Cumulative percentages by day detected and median TTD of initial and follow-up specimens were analyzed. The median TTD-MTBC for MGIT (n = 6 sites) was 14 days. For laboratories using standard processing procedures, 100% of MTBC were detected from initial and follow-up specimens in 28 and 35 days, respectively, and no yield of MTBC on solid or MGIT liquid media was observed after 5 weeks. The median TTD-MTBC for BacT/Alert (n = 3 sites) was 18 days, with 95% and 100% detected within 37 and 42 days, respectively. Analysis of TTD of positive MTBC cultures in broth can predict the probability of culture negativity at defined time points. Receipt of interim negative reports earlier than 6 weeks could assist clinicians in considering alternative diagnoses and could alter the timing and prioritization of public health interventions. Laboratories should analyze their own TTD data to inform protocol decisions. Laboratories using MGIT could issue reports of no growth of MTBC on initial specimens as early as 4 weeks and for patients undergoing treatment as early as 5 weeks postinoculation.
Heart failure in patients with atrial fibrillation in Europe: a report from the EURObservational Research Programme Pilot survey on Atrial Fibrillation

The purpose of this study was too describe the associated baseline features of AF patients with heart failure (HF) with reduced and preserved ejection fraction (HFrEF and HFpEF). Secondly, we assessed symptomatic status and their clinical correlates. Finally, we examined independent predictors for ‘heart failure’ at the 1‐year follow‐up period.
Behavioral signs of acute pain produced by application of endothelin‐1 to rat sciatic nerve

WE examined whether endothelin-1 (ET-1), a potent vasoconstrictive peptide secreted in high concentration by metastatic prostate cancer cells, produces endothelin receptor-dependent pain behavior when applied to rat sciatic nerve. ET-1 (200–800 μM) applied to the epineurial surface of rat sciatic nerve produced reliable, robust, unilateral hindpaw flinching lasting 60 min. Preemptive systemic morphine completely blocked this effect in a naloxone-reversible manner, suggesting that this behavior was pain-related. Equipotent doses of epineurially applied epinephrine had no effect, suggesting that ET-1 effects are on tissue sites other than sciatic nerve microvessels. Prior and co-administration of BQ-123, an endothelin-A (ETA) receptor antagonist, also blocked ET-1-induced hindpaw flinching establishing that pain behavior induced by ET-1 application to rat sciatic nerve is ETA receptor mediated.
Barley MLA Immune Receptors Directly Interfere with Antagonistically Acting Transcription Factors to Initiate Disease Resistance Signaling[C][W]

The barley immune receptor MLA mediates disease resistance against powdery mildew fungal pathogens. Upon activation, MLA directly interacts with two antagonistically acting transcription factors, MYB6 and WRKY1. MYB6 positively regulates basal and MLA-mediated immune responses, while MYB6 DNA binding is antagonized by direct association with WRKY1 but enhanced by MLA interaction. The nucleotide binding domain and Leucine-rich repeat (NLR)–containing proteins in plants and animals mediate pathogen sensing inside host cells and mount innate immune responses against microbial pathogens. The barley (Hordeum vulgare) mildew A (MLA) locus encodes coiled-coil (CC)–type NLRs mediating disease resistance against the powdery mildew pathogen Blumeria graminis. Here, we report direct interactions between MLA and two antagonistically acting transcription factors, MYB6 and WRKY1. The N-terminal CC signaling domain of MLA interacts with MYB6 to stimulate its DNA binding activity. MYB6 functions as a positive regulator of basal and MLA-mediated immunity responses to B. graminis. MYB6 DNA binding is antagonized by direct association with WRKY1 repressor, which in turn also interacts with the MLA CC domain. The activated form of full-length MLA10 receptor is needed to release MYB6 activator from WRKY1 repression and to stimulate MYB6-dependent gene expression. This implies that, while sequestered by the WRKY1 repressor in the presence of the resting immune receptor, MYB6 acts as an immediate and positive postactivation signaling component of the active state of MLA during transcriptional reprogramming for innate immune responses.
T2*-weighted MRI findings of superficial siderosis.

A 52-year-old man presented with progressive hearing loss and gait disturbance. Neurological examination showed mild cognitive impairment, cerebellar ataxia, and bilateral sensorineural hearing loss. Cerebrospinal fluid analysis showed xanthochromic fluid with an increased protein level (135 mg/dL) and the absence of red blood cells. Magnetic resonance imaging showed extensive hypointensity, which delineated the surfaces of the brainstem, cerebellum, sylvian fissure, and spinal cord, on T2-weighted images (Picture 1a, b). These findings were differentiated more clearly on T2*-weighted images (Picture 1c, d, arrows), therefore we diagnosed superficial siderosis. No obvious causes of chronic subarachnoid hemorrhage were identified. Superficial siderosis is caused by chronic hemosiderin deposition in the subpial layers of the brain and spinal cord, which leads to gradual progressive neurologic deterioration (1). T2*weighted imaging and susceptibility-weighted imaging can sensitively detect hemosiderin deposition and their usefulness for the diagnosis of superficial siderosis has been reported (2). T2*-weighted images greatly contributed to determination of the diagnosis in this case.
Reduced Stacked Multicell converter with minimized stored energy of flying capacitors

In this paper a new configuration of flying capacitor based multicell converter with a fewer number of power electronic switches has been introduced. Using the proposed configuration of Stacked Multicell converter, the number of output voltage levels and the RMS are doubled and the output voltage frequency spectrum has been improved. Also, the number and rating of components and the converter losses are decreased in comparison with conventional flying capacitor based converters. Furthermore, proposing a matrix configuration in this converter, the total stored energy of flying capacitors can be minimized. This configuration is based on Stacked Multicell converter and achieved by removing the switches generating negative half cycle of output waveform, which decreases the number of high frequency switches to half, and adding only two low-frequency switches to a matrix based structure of Stacked Multicell converter. A modified Phase Shifted Pulse Width Modulation control scheme has been applied to the proposed topology in order to maintain the natural balancing capability of flying capacitors. The simulation results obtained from PSCAD/EMTDC software confirm the validation of this proposed configuration advantages and its control method.