Miracle-dz/UniFAR-FTUs huggingface dataset:
Diaphragm muscle thinning in patients who are mechanically ventilated.

BACKGROUND Approximately 40% of patients in medical ICUs require mechanical ventilation (MV). Approximately 20% to 25% of these patients will encounter difficulties in discontinuing MV. Multiple studies have suggested that MV has an unloading effect on the respiratory muscles that leads to diaphragmatic atrophy and dysfunction, a process called ventilator-induced diaphragmatic dysfunction (VIDD). VIDD may be an important factor affecting when and if MV can be discontinued. A sensitive and specific diagnostic test for VIDD could provide the physician with valuable information that might influence decisions regarding extubation or tracheostomy. The purpose of this study was to quantify, using daily sonographic assessments, the rate and degree of diaphragm thinning during MV. METHODS Seven intubated patients receiving MV during acute care were included. Using sonography, diaphragm muscle thickness was measured daily from the day of intubation until the patient underwent extubation or tracheostomy or died. We analyzed our data using standard descriptive statistics, linear regression, and mixed-model effects. RESULTS The overall rate of decrease in the diaphragm thickness of all seven patients over time averaged 6% per day of MV, which differed significantly from zero. Similarly, the diaphragm thickness decreased for each patient over time. CONCLUSION Sonographic assessment of the diaphragm provides noninvasive measurement of diaphragmatic thickness and the degree of diaphragm thinning in patients receiving MV. Our data show that diaphragm muscle thinning starts within 48 h after initiation of MV. However, it is unclear if diaphragmatic thinning correlates with diaphragmatic atrophy or pulmonary function. The relationship between diaphragm thinning and diaphragm strength remains to be elucidated.
Random Forest as a Predictive Analytics Alternative to Regression in Institutional Research.

In institutional research, modern data mining approaches are seldom considered to address predictive analytics problems. The goal of this paper is to highlight the advantages of tree-based machine learning algorithms over classic (logistic) regression methods for data-informed decision making in higher education problems, and stress the success of random forest in circumstances where the regression assumptions are often violated in big data applications. Random forest is a model averaging procedure where each tree is constructed based on a bootstrap sample of the data set. In particular, we emphasize the ease of application, low computational cost, high predictive accuracy, flexibility, and interpretability of random forest machinery. Our overall recommendation is that institutional researchers look beyond classical regression and single decision tree analytics tools, and consider random forest as the predominant method for prediction tasks. The proposed points of view are detailed and illustrated through a simulation experiment and analyses of data from real institutional research projects.
Lone atrial fibrillation: what do we know?

Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Despite the common association of AF with cardiovascular disease, some patients can be classified as ‘lone AF’. The latter is essentially a diagnosis of exclusion, and should be preceded by careful evaluation, including thorough collection of medical history, physical examination, blood pressure measurement, laboratory tests, ECG, echocardiography and, possibly, chest x-ray and exercise testing. Lone AF patients were initially thought to have a good prognosis with respect to thromboembolism and mortality, compared with the general AF population, but more recent data suggest otherwise. This review focuses on the clinical epidemiology and management aspects of lone AF, as well as various associated novel risk factors, such as familial, genetic and socioeconomic factors, alcohol, sports activity and biochemical markers.
Influence of activation state of ErbB-2 (HER-2) on response to adjuvant cyclophosphamide, doxorubicin, and fluorouracil for stage II, node-positive breast cancer: study 8541 from the Cancer and Leukemia Group B.

PURPOSE ErbB-2 (human epidermal growth factor receptor 2) overexpression may be predictive of relative resistance and/or sensitivity to specific chemotherapeutic agents. Results from a previous study from the Cancer and Leukemia Group B (CALGB 8541) demonstrated an interaction between ErbB-2 and increasing dose of adjuvant cyclophosphamide, doxorubicin, and fluorouracil (CAF) chemotherapy. Other studies have suggested that evaluation of the phosphorylated/activated form of ErbB-2 might be more precise in defining the impact of ErbB-2 in breast cancer. We have evaluated tumor tissue sections from CALGB 8541 patients to determine whether the interaction of ErbB-2 with CAF dose is dependent on ErbB-2 activation state, and whether phosphorylated ErbB-2 is an adverse prognostic factor in patients treated with CAF. PATIENTS AND METHODS Patients were randomly assigned to one of three dosing regimens of CAF. Paraffin samples from 992 of 1,572 patients who participated in CALGB 8541 were available. Of the 570 tumors with any staining for ErbB-2, 488 had tissue available for assay for phosphorylated ErbB-2, which was performed by immunohistochemistry. RESULTS Of 910 total assessable cases, 112 of 488 ErbB-2-positive cases (23%) stained positively for phosphorylated ErbB-2. The previously described interaction of dosing regimen of CAF with ErbB-2 was not dependent on phosphorylation status of ErbB-2. CONCLUSION Monitoring phosphorylation of ErbB-2 with an antiphospho-ErbB-2 antibody did not add further precision to identifying those patients most likely to benefit from increased dose of anthracycline-based adjuvant chemotherapy. Favorable outcomes are observed in ErbB-2-overexpressing patients treated with high-dose CAF regardless of ErbB-2 phosphorylation state.
Effects of Carbamazepine and Oxcarbazepine on the Reproductive Endocrine Function in Women with Epilepsy

Summary: Purpose: The aim of the study was to compare the effects of carbamazepine (CBZ) and oxcarbazepine (OXC) on the reproductive endocrine function in women with epilepsy. OXC is a novel antiepileptic drug (AED), and the occurrence of reproductive dysfunction in women treated with OXC monotherapy for epilepsy has not been studied previously.
CEFTA agreement as a vehicle for economic cooperation in see

The aim of this paper is to indicate the importance of economic cooperation for the development of regional economy of CEFTA countries and achieving better results using advantages of joint projects and access to third markets. As a free trade agreement, CEFTA has facilitated increased cooperation in the region, particularly among traditional partners that welcome the use of zero-rate customs. Ten years after signing the agreement, marked by constant improvement of trading terms between partners, CEFTA members have to find new ways to increase their trade in the conditions of economic stagnation and expand it with the EU countries. New synergies have to be achieved in order to raise trade above the current level. Also, every CEFTA member has to make an effort to resolve political conflicts and remove any nontariff barriers that could limit current cooperation. Finally, the importance of CEFTA is paramount for accession of each Western Balkan country to the EU.
Studies in Cranial Suture Biology: IV. Temporal Sequence of Posterior Frontal Cranial Suture Fusion in the Mouse

&NA; The biology underlying normal and premature cranial suture fusion remains unknown. To develop a model for normal cranial suture fusion, the temporal sequence of the posterior frontal cranial suture fusion in the mouse was determined. To do this, all the cranial sutures of three distinct strains of mice (CD‐1, CF‐1, and C57bl‐6) were studied histologically for fusion at sequential time points. Two studies were set up using group A mice (n = 72, all sutures studied) and group B mice (n = 78, only the posterior frontal suture studied, but more precisely along its anatomic length). In the group A cranial suture study, mice were sacrificed starting at newborn age and then every 5 days until age 50 days. In addition, two mature mice (250 days old) from each strain were sacrificed. In all three mouse strains, histologic examinations showed that the anterior frontal, sagittal, coronal, lambdoid, and occipitointerparietal sutures remained patent at up to 50 days of age and were patent in the 250‐day mature mice. However, examination of the midpoint of the posterior frontal suture showed patency at 30 days, partial fusion at 35 days, and complete fusion by 40 days. These data prompted the posterior frontal suture fusion study. In the group B posterior frontal suture fusion study, mice were sacrificed at age 23 days and then every 2 days until 47 days of age. The anterior, midpoint, and posterior aspects of the posterior frontal suture were examined: The anterior aspect fused between 25 and 29 days; the midpoint fused between 31 and 37 days; and the posterior aspect fused between 39 and 45 days. These data indicate that fusion of the posterior frontal cranial suture in the mouse proceeds in a defined temporal sequence from an anterior to posterior direction in three distinct strains of mice, while in the same mice all other cranial sutures remain patent. By describing and understanding the fusion of the normal posterior frontal suture, a biologic basis of normal suture development and fusion can be established and used as a comparison for murine cranial sutures altered surgically, biochemically (with growth factors), or genetically (with craniosynostotic phenotypes).
Inactivated bovine herpesvirus 1 induces apoptotic cell death of mitogen-stimulated bovine peripheral blood mononuclear cells

Bovine herpesvirus 1 (BHV-1) is able to inhibit the proliferation of bovine peripheral blood mononuclear cells. Here, we have demonstrated that live BHV-1 and, interestingly, inactivated BHV-1 can induce apoptosis of mitogen-stimulated bovine peripheral blood mononuclear cells in vitro.
The Impact of liquidity on Economic Growth in America's Economy Using a New Approach TVP-FAVAR

This article explores the impact of inflation rate on Economic Growth of the state. There is an immense effect of monetary policy on Economic Growth of the country. In this regard variables have been studied to prove the hypothesis. The data of past 47 years from 1970 to 2016 has been used for driving the result. To determine the relationship between two liquidity on Economic Growth TVP-FAVR technique has been used. Based on the results of liquidity in th e short term, medium term and long term positive impact on economic growth.
Drivetrain design for an ultra light electric vehicle with high efficiency

The complete drivetrain for a single person ultra light electric vehicle (EV) is optimized towards a minimal total weight and a maximal average efficiency for different driving cycles. The EV is named ELBEV, which is an acronym for Ecologic Low Budget Electric Vehicle. The single person ultra light EV is a tricycle, with two driven and steering front wheels and one rear wheel. The drivetrain of each front wheel consists of an outer rotor permanent magnet synchronous motor (PMSM), a single-stage gearbox and the power electronics with converter and controller print. The drivetrain is optimized for the New European Driving Cycle, the New York City Cycle and the Federal Test Procedure. For the optimization of the drivetrain analytical models are used to calculate the losses and the efficiency. The optimized parameters of the motor are: the number of pole pairs, the number of stator slots and the outer rotor radius of the motor. Furthermore, an analytical model for the single-stage gearbox is implemented for different gear ratios (GRs). The optimized parameters for the gearbox are: the number of teeth and the module of each gear combination and the total mass of the gearbox for each GR. The analytical models are fast, and useful for designing a good PMSM in combination with a single-stage gearbox. The optimization of the complete drivetrain is always a compromise between total average efficiency over the drive cycle and the total mass of the drivetrain.
Desired Turbulence? Gut-Lung Axis, Immunity, and Lung Cancer

The microbiota includes different microorganisms consisting of bacteria, fungi, viruses, and protozoa distributed over many human body surfaces including the skin, vagina, gut, and airways, with the highest density found in the intestine. The gut microbiota strongly influences our metabolic, endocrine, and immune systems, as well as both the peripheral and central nervous systems. Recently, a dialogue between the gut and lung microbiota has been discovered, suggesting that changes in one compartment could impact the other compartment, whether in relation to microbial composition or function. Further, this bidirectional axis is evidenced in an, either beneficial or malignant, altered immune response in one compartment following changes in the other compartment. Stimulation of the immune system arises from the microbial cells themselves, but also from their metabolites. It can be either direct or mediated by stimulated immune cells in one site impacting the other site. Additionally, this interaction may lead to immunological boost, assisting the innate immune system in its antitumour response. Thus, this review offers an insight into the composition of these sites, the gut and the lung, their role in shaping the immune system, and, finally, their role in the response to lung cancer.
Anaesthesia in patients with dementia

Purpose of review The next couple of decades will be characterized by an increase in life expectancy, leading to an older population. As the incidence of Alzheimer's dementia and vascular dementia is rising with age, the future anaesthesiologist will be increasingly confronted with perioperative care of patients with impaired cognitive function. This paper tries to highlight some topics specifically related to demented patients. Recent findings Psychometric testing and behaviour vary according to the type of dementia. Neuroanatomical and biochemical correlates for different types of dementia are more precise and better documented. Evidence exists that cognition may be impaired for weeks after anaesthesia, but the mental capacities of those who have undergone surgery are comparable to those of age controls in the long term. Most research efforts are focused on improving the daily functioning of people with cognitive impairment. Several new anticholinesterases are being evaluated. It is advantageous to keep cognition optimal throughout the perioperative period. Neuroleptics may be badly tolerated and, most importantly, pain pathways may be differentially affected in dementia. Summary Anaesthesia in the demented patient may be complicated by a number of potential problems, including the comorbid pathology, the concomitant anticholinesterase activity, the need for normoventilation, monitoring of anaesthesia depth and the evaluation of postoperative pain. Anaesthesia in variant Creutzfeldt-Jakob disease is aimed at preventing the spread of the causing prion. There is a broad consensus that early return to the preoperative level of cognition is to be pursued, with the help of short-acting drugs and loco-regional anaesthesia.
THE ERA OF AGING CHILDREN AND ELDERLY PARENTS: SOMETHING NEW IN EMOTIONAL EPIDEMIOLOGY

kind of personal conflicts with this paper. Author Contributions: Blandine Bénet: manuscript preparation. Jean-François Alexandra: physician in charge of the patient and helped write the manuscript. Valérie Andrieu: performed bone marrow aspiration and took part in the last reading of the manuscript. Frederic Sedel: helped in the diagnosis and manuscript preparation. Nadine Ajzenberg: manuscript preparation. Thomas Papo: took part in the last reading of the manuscript. Sponsor’s Role: None.
A Political Ecology of Exurbia in the Sunbelt: Lessons from an Award-Winning, “Unworkable” Plan

Sarasota County, Florida’s award-winning Sarasota 2050 plan established the county as a leader in smart growth. The plan promotes a system of clustered development and open space as an alternative to sprawl beyond Sarasota’s growth boundary. Although adopted in 2002, by 2011, no projects had broken ground under the plan, which critics deemed “unworkable. ” This article presents a case study of exurban political ecology in Sarasota to provide insight into the derailment of a promising strategy for managing exurban growth. Sarasota 2050’s policies were undermined by extra-local factors, including the recession and reduced state oversight of planning, and by incompatible policy agendas pursued by local interest groups. Also problematic was the plan’s cluster approach—a spatial strategy that rationalizes large landowner, planning, and conservation interests, but does little to address rural restructuring. The case points to the need for new planning strategies that mediate competing interests in exurbia.
A New Method for Avoiding the Truncation Error in Near-Field Antennas Measurements

A new method to avoid the truncation error in antenna near-field measurements is presented. The approach relies on the concept of information content of the field. According to this point of view, the truncation problem is solved by picking up the information that is lost due to the finite size of scanning area, in points of the space reachable by the measurement system. The method can be applied to any scanning geometry, including the planar and cylindrical ones, whenever the set-up allows to vary the distance between the antenna under test and the probe during the scanning procedure. Application of the method to cylindrical near-field scanning is numerically investigated, assessing the effectiveness of the proposed technique
Two RGS proteins that inhibit Galpha(o) and Galpha(q) signaling in C. elegans neurons require a Gbeta(5)-like subunit for function.

BACKGROUND Gbeta proteins have traditionally been thought to complex with Ggamma proteins to function as subunits of G protein heterotrimers. The divergent Gbeta(5) protein, however, can bind either Ggamma proteins or regulator of G protein signaling (RGS) proteins that contain a G gamma-like (GGL) domain. RGS proteins inhibit G protein signaling by acting as Galpha GTPase activators. While Gbeta(5) appears to bind RGS proteins in vivo, its association with Ggamma proteins in vivo has not been clearly demonstrated. It is unclear how Gbeta(5) might influence RGS activity. In C. elegans there are exactly two GGL-containing RGS proteins, EGL-10 and EAT-16, and they inhibit Galpha(o) and Galpha(q) signaling, respectively. RESULTS We knocked out the gene encoding the C. elegans Gbeta(5) ortholog, GPB-2, to determine its physiological roles in G protein signaling. The gpb-2 mutation reduces the functions of EGL-10 and EAT-16 to levels comparable to those found in egl-10 and eat-16 null mutants. gpb-2 knockout animals are viable, and exhibit no obvious defects beyond those that can be attributed to a reduction of EGL-10 or EAT-16 function. GPB-2 protein is nearly absent in eat-16; egl-10 double mutants, and EGL-10 protein is severely diminished in gpb-2 mutants. CONCLUSIONS Gbeta(5) functions in vivo complexed with GGL-containing RGS proteins. In the absence of Gbeta(5), these RGS proteins have little or no function. The formation of RGS-Gbeta(5) complexes is required for the expression or stability of both the RGS and Gbeta(5) proteins. Appropriate RGS-Gbeta(5) complexes regulate both Galpha(o) and Galpha(q) proteins in vivo.
Ergodic bilevel optimization

—In image and signal processing and beyond, quantities of interest are often reconstructed from noisy measurements by means of suitable convex optimization problems. While model based approaches usually assume that the ingredients of the problem are a priori known, data driven approaches are motivated by situations where the objective function or constraints of the problem are partially unknown and shall be learned from data. This gives rise to bilevel optimization problems in which the original convex problem (hereafter referred to as the lower-level problem) appears as a constraint. Applying gradient based algorithms to bilevel optimization problems poses the difﬁculty to differentiate through the solution operator of the lower-level problem. In this contribution, we consider the approach to unroll a ﬁxed number of update steps of the Chambolle-Pock algorithm applied to the lower-level problem in order to accomplish this kind of differentiation approximately. We investigate the asymptotic behavior of the resulting gradients and conclude that unrolling ergodic averages instead of ordinary iterates can have a positive effect upon the learning dynamics.
The SOCS box—Adapting proteins for ubiquitination and proteasomal degradation

The suppressor of cytokine signalling (SOCS) box was first identified in the SH2‐containing SOCS box family (cytokine‐inducible SH2‐containing protein, SOCS1–7) and is a 40‐amino acid motif, which functions to recruit an E3 ubiquitin ligase complex consisting of the adapter proteins elongins B and C, Rbx2 and the scaffold protein Cullin5. The SOCS box is found in a diverse array of intracellular signalling molecules, many of which contain different protein interaction domains such as SPRY and WD40 domains, leucine and ankyrin repeats or other functional domains such as GTPases. In general, the SOCS box‐containing proteins are thought to act as substrate‐recognition modules to mediate the polyubiquitination and subsequent degradation of substrate proteins by the 26S proteasome. © 2012 IUBMB Life, 64(4): 316–323, 2012
Deciphering the Responses of Root Border-Like Cells of Arabidopsis and Flax to Pathogen-Derived Elicitors1[C][W]

Root border-like cells of flax and Arabidopsis activate innate immunity responses to elicitors involving both callose deposition and cell wall extensin reorganization. Plant pathogens including fungi and bacteria cause many of the most serious crop diseases. The plant innate immune response is triggered upon recognition of microbe-associated molecular patterns (MAMPs) such as flagellin22 and peptidoglycan. To date, very little is known of MAMP-mediated responses in roots. Root border cells are cells that originate from root caps and are released individually into the rhizosphere. Root tips of Arabidopsis (Arabidopsis thaliana) and flax (Linum usitatissimum) release cells known as “border-like cells. ” Whereas root border cells of pea (Pisum sativum) are clearly involved in defense against fungal pathogens, the function of border-like cells remains to be established. In this study, we have investigated the responses of root border-like cells of Arabidopsis and flax to flagellin22 and peptidoglycan. We found that both MAMPs triggered a rapid oxidative burst in root border-like cells of both species. The production of reactive oxygen species was accompanied by modifications in the cell wall distribution of extensin epitopes. Extensins are hydroxyproline-rich glycoproteins that can be cross linked by hydrogen peroxide to enhance the mechanical strength of the cell wall. In addition, both MAMPs also caused deposition of callose, a well-known marker of MAMP-elicited defense. Furthermore, flagellin22 induced the overexpression of genes involved in the plant immune response in root border-like cells of Arabidopsis. Our findings demonstrate that root border-like cells of flax and Arabidopsis are able to perceive an elicitation and activate defense responses. We also show that cell wall extensin is involved in the innate immunity response of root border-like cells.