Miracle-dz/UniFAR-FTUs huggingface dataset:
Der Teufelskreis aus Schmerz, Angst und Bewegungsvermeidung: Ursachen und mögliche Auswege

8 Menschen mit chronischen Schmerzen haben mitunter Angst vor bestimmten Bewegungen. Sie vermeiden entsprechende Aktivitäten, bauen körperlich ab und leiden schlimmstenfalls unter noch stärkeren Schmerzen und Depressionen. Die Ursache für ihre ‚Kinesiophobie‘ liegt in bewegungsassoziierten Negativerfahrungen, im sozialen Umfeld und auch in der unbeabsichtigten Fehlkommunikation oder etwaigen Verunsicherung von Therapeuten. Die Expositionstherapie sowie das Graded-Activity-Konzept helfen, um den Teufelskreis des Angst-Vermeidungs-Modells zu durchbrechen.
Assessment of Suicidality Risk Factors and Its Management at Poison Control Center Cairo University

This study aimed at assessing the suicidality risk factors and its management among adolescents. A descriptive correlational design was utilized in this study. Convenient sample consisted of 300 suicidal attempters was selected; who were admitted to Poison Control Center, Cairo University over a period of three months. Tools for data collection; Socio-demographic/medical data sheet, Perceived Social Support Scale, Beck Depressive Inventory Scale, Beck Suicidal Ideation Scale, Life Stressors questionnaire and Management questionnaire. Results revealed that most of attempters were female adolescents, showed a higher tendency to be single, unemployed, moderate education , resided urban areas, using drug self poisoning ,showed none previous attempts ,high suicidal ideation , moderate depression and the most prominent problems were family problems. Attempters found to have received low family support, high friend support and receive only medical management. Suicide attempters need social and emotional support from their significant others. [Nareman Aly, Sayeda Abdel Latief , Ahmed Abdel Latief, and Abdel Rahman El Naggar. Assessment of Suicidality Risk Factors and Its Management at Poison Control Center Cairo University(Adolescence suicidality). J Am Sci 2012;8(9):724-728]. (ISSN: 1545-1003). http://www.jofamericanscience. org. 99
Effects of Whole Body Electromyostimulation on Muscle Activity and Muscle Thickness of Rectus Femoris, and Muscle Thickness of Abdominis Muscle in Healthy Adults

Background: Whole body-electromyostimulation (WB-EMS) is widely used for the rehabilitation and recovery of patients with various neuromusculoskeletal disorders.Objects: To objectively measure changes in lower extremity and abdominal muscles after sit-to-stand dynamic movement training using WB-EMS.Methods: A total of 46 healthy adults (23 experimental and 23 control subjects) performed sit-to-stand exercise; the experimental group with WB-EMS, and the control group without WB-EMS. The muscle activity of the lower extremity, and the muscle thickness of the lower extremity and abdominal muscles were measured before and after the intervention.Results: In terms of electromyographic activity, there was a significant interaction effect for the rectus femoris (RF) muscle (F=30.212, p=.000). With regards to ultrasonographic imaging, the muscle thickness of the RF muscle had a significant interaction effect at the muscle contraction ratio (F=8.071, p=.007). The deep abdominal muscles, such as the transverse abdominal (TrA) and internal oblique (IO) muscles, also showed significant interaction effects at the muscle contraction ratio (F=5.474, p=.024, F=24.151, p=.000, respectively)Conclusion: These findings suggest that WB-EMS may help to improve the muscular activity of the RF muscle, and the muscle thickness of the RF muscle and deep muscles such as the TrA and IO muscles.
Online Consumers’ Buying Behavior Perspective on Instagram Platform

The study aims at analyzing the influence of Celebrity Endorser, Information Quality, Viral Marketing and Trust on Purchase Decision of @21onshop Instagram Account. Within the conduct of the study, the data that had been gathered were the primary data that had been attained by means of online questionnaire distribution from February until April 2019. The number of sample that had been involved was 195 people and these samples were selected by means of incidental sampling technique. Then, the researcher tested the data validity, the data reliability and the hypotheses within the study by means of Structural Equation Modelling in LISREL Program. The results of the study show that both Celebrity Endorser and Viral Marketing do not have significant influence on Purchase Decision over Instagram whereas both Information Quality and Consumer Trust have significant influence on Purchase Decision over Instagram.
Effekte pharmakologischer Interventionen auf Muskelatrophie im Mausmodell der amyotrophen Lateralsklerose (ALS)

XV 1 EINLEITUNG . 1 1.1 Amyotrophe Lateralsklerose. 1 1.1.1 Grundlagen des Krankheitbildes . 1 1.1.2 Ursachen. 2 1.1.3 Therapie . 6 1.2 Kachexie . 8 1.2.1 Definition . 8 1.3 Regulation des Kataund Anabolismus. 9 1.3.1 Energiestoffwechsel . 9 1.3.2 Inflammation . 11 1.3.2.1 Zytokine . 12 1.3.3 Proteinstoffwechsel im Skelettmuskel . 13 1.3.3.1 Myostatin-Signalkaskade . 14 1.3.3.2 Akt-Signalkaskade . 18 1.3.3. 3 Ubiquitin-Proteasom-System . 19 1.3.3.4 Apoptose . 22 1.3.3.5 Autophagie . 23 1.4 Beta-Blocker . 25 1.5 Zielsetzung . 27
Heurísticas para Data Augmentation en NLP: Aplicación a Revisiones de Artículos Científicos

espanolLas tecnicas de data augmentation son esenciales para entrenar algoritmos de machine learning, donde el conjunto de datos inicial es mas pequeno que lo requerido debido a la complejidad del modelo. En modelos de aprendizaje automatico, la robustez del proceso de entrenamiento depende altamente de grandes volumenes de datos etiquetados, los cuales son costosos de producir. Un enfoque eficaz para tratar con este problema es generar automaticamente nuevos ejemplos etiquetados usando tecnicas de data augmentation. En el procesamiento del lenguaje natural, en particular en el idioma espanol, hay una falta de tecnicas bien definidas que permitan incrementar un conjunto de datos. En este articulo, se proponen un conjunto de heuristicas para data augmentation en NLP, las cuales son aplicadas en el dominio de las revisiones de articulos cientificos. EnglishData augmentation techniques are essential for training machine learning algorithms, where the initial data set is smaller than required due to the model complexity. In machine learning models, the robustness of the training process is highly dependent on large volumes of labeled data, which are expensive to produce. An effective approach to deal with this problem is to automatically generate new tagged examples using data augmentation techniques. In the processing of natural language, particularly in the Spanish language, there is a lack of well-defined techniques that allow increasing a set of data. In this article, we propose a set of heuristics for data augmentation in NLP, which are applied to the domain of reviews of scientific articles.
Modeling and Control of the UGV Argo J5 with a Custom-Built Landing Platform

This thesis aims to develop a detailed dynamic model and implement several navigation controllers for path tracking and dynamic self-leveling of the Argo J5 Unmanned Ground Vehicle (UGV) with a custom-built landing platform. The overall model is derived by combining the Argo J5 driveline system with the wheelsterrain interaction (using terramechanics theory and mobile robot kinetics), while the landing platform model follows the Euler-Lagrange formulation. Different controllers are, then, derived, implemented to demonstrate: i. ) self-leveling accuracy of the landing platform, ii. ) trajectory tracking capabilities of the Argo J5 when moving in uneven terrains. The novelty of the Argo J5 model is the addition of a vertical load on each wheel through derivation of the shear stress depending on the point’s position in 3D space on each wheel. Static leveling of the landing platform within one degree of the horizon is evaluated by implementing Proportional Derivative (PD), Proportional Integral Derivative (PID), Linear Quadratic Regulator (LQR), feedback linearization, and Passivity Based Adaptive Controller (PBAC) techniques. A PD controller is used to evaluate the performance of the Argo J5 on different terrains. Further, for the Argo J5 landing platform ensemble, PBAC and Neural Network Based Adaptive Controller (NNBAC) are derived and implemented to demonstrate dynamic self-leveling. The ii emphasis is on different controller implementation for complex real systems such as Argo J5 Landing platform. Results, obtained via extensive simulation studies in a Matlab/Simulink environment that consider real system parameters and hardware limitations, contribute to understanding navigation performance in a variety of terrains with unknown properties and illustrate the Argo J5 velocity, wheel rolling resistance, wheel turning resistance and shear stress on different terrains.
Steatometry and elastometry as methods of noninvasive diagnostics of pancreatic steatosis and fibrosis in children

Background. Obesity is associated with accumulation of fat in parenchymal organs, including pancreas, with formation of its steatosis. Pancreatic steatosis can lead to chronic inflammation and fibrosis of the pancreas. Limitation in invasive studies in children causes need of development and implementation of advanced non-invasive methods for pancreatic observation. The purpose of our study was to investigate the possibility of ultrasound diagnosis of steatosis and fibrosis of the pancreas in children using steatometry (estimation of ultrasound attenuation) and elastometry. Materials and methods. We examined 60 children hospitalized in the Department of Pediatric Gastroenterology of SI “Institute of Gastroenterology of NAMS of Ukraine”. The patients were grouped on the basis of of obesity and overweight presence: group 1 consisted of 44 patients with obesity and overweight, group 2 consisted of 16 children with normal weight. Sonological research, elastometry, steatometry of the pancreas were made using apparatus Ultima PA Expert (“Radmir”, Ukraine). The presence and degree of pancreatic steatosis using pair-wise comparison of pancreatic echogenicity with renal and retroperitoneal fat echogenicity. Results. 25 patients of group 1 (56.8 %) were found to have sonological signs of pancreatic steatosis; third of patients had sonographic signs of non-specific inflammatory changes in the pancreas. We found that the average coefficient of ultrasound attenuation was significantly higher in children of group 1 compared to group 2 (p < 0.05) and amounted to (2.45 ± 0.39) dB/cm in group 1 and (1.8 ± 0.23) dB/cmin group2. The average pancreas stiffness in children with normal weight group was higher compared to patients with obesity and overweight, but the significance of differences was not sufficient and amounted (3.69 ± 0.78) kPa in group 1 and (3.78 ± 0.27) kPa in group 2. Conclusions. We established that the average coefficient of ultrasound attenuation during pancreatic sonological study in children with obesity and overweight was significantly higher compared to the patients with normal weight that can be explained by the presence of pancreatic steatosis in children with obesity/overweight. The study demonstrates the possibility of steatometry and elastometry usage for diagnosis of pancreatic steatosis and fibrosis in children.
Exploring the roles of the SMC5/6 complex in cancer, ageing and kidney disorders

PRESENTACIÓN. INTRODUCTION. 1 Maintenance of genomic integrity. 1.1 Sources of DNA damage and the DDR response. 1.2 Replication stress is a major threat to genomic integrity. 1.3 Homologous recombination-mediated repair and processing of Holliday junctions. 1.4 Consequences of replication stress in mitosis. 2 Physiological outcome of defective DNA damage response. 2.1 Genomic instability can trigger cancer and ageing. 2.2 Defective DNA repair syndromes. 2.2.1 Premature ageing syndromes. 2.2.2 Cancer-prone syndromes. 2.3 DNA damage and kidneys disorders. 3 Structural Maintenance of Chromosomes. 3.1 Architecture of the SMC5/6 complex. 3.2 The enigmatic role the SMC5/6 complex in chromosome maintenance. 3.3 Mutations of the SMC5/6 complex in humans. OBJECTIVES. 13
Promising Effect of Treatment at Early Adolescent Age: A Case Report

Aim of this study was to see the effect of bionator in early permanent dentition phase. Bionator from its inception and evolution of the appliance itself has been widely accepted as a more competent class II corrector. The bionator has both dentalveolar and skeletal effect. This appliance can be used successfully in growing patient with certain class II malocclusion. It also simplifies the fixed appliance phase. An 11-year-old boy was treated with bionator appliance and treatment results were demonstrated in following case report. In permanent dentition, bionator produce similar effect as in mixed dentition phase. With proper case selection and good patient cooperation, we can obtain a significant result with bionator appliance.
Propagación de Erato polymnioides, en combinaciones de sustratos, reguladores de crecimiento y agrupación de plántulas

espanolErato polymnioides es una especie hiperacumuladora de metales pesados que puede utilizarse en proyectos de biorremediacion en zonas mineras. A pesar de su importancia, no se conocen procesos de propagacion de esta especie, por lo que se planteo identificar condiciones optimas para su propagacion en condiciones de invernadero. Se realizaron varios ensayos; los primeros fueron basados en 4 clases de sustratos y 2 concentraciones de reguladores de crecimiento aplicados en estacas; para el segundo grupo, se usaron 2 clases de sustratos y plantulas, germinadas de alrededor de 2 meses, que se colocaron de manera agrupadas y sin agrupar. Del ensayo con estacas se observo mayor formacion y crecimiento de raices, brotes y hojas en suelo del sitio en el que se desarrolla la especie, con y sin paclobutrazol, mientras que la agrupacion de 3 plantulas germinadas y sembradas en abono/turba presentaron las mejores respuestas de prendimiento. Los resultados muestran que la especie se desarrolla mejor en sustratos preparados cuando esta en etapas iniciales, mientras que cuando es propagada por estacas se adapta mejor al sustrato del sitio de donde provienen, el cual se caracteriza por alto contenido de arcilla y, posiblemente, microorganismos que tengan una relacion simbiotica con la especie. EnglishErato polymnioides is a hyperaccumulating species of heavy metals which can be used in bioremediation projects in mining areas. Despite its importance, no propagation processes for this species are known, thus it was proposed to identify optimal conditions for its propagation under greenhouse conditions. Some trials were performed; the first ones were based on 4 classes of substrates and 2 concentrations of growth regulators applied to cuttings. For the other trials, 2 kinds of substrates and seedlings, germinated for about two months were used, the seedlings were grouped or ungrouped. The cuttings trial showed greater root formation and growth, shoots and leaves in soil of the site in which the species develops, with and without paclobutrazol, while the group of 3 seedlings germinated and sown in organic fertilizer/peat presented the best performance responses. The results show that this species develops better on prepared substrates when it is in early stages, whereas when it is propagated by cuttings it adapts better to the substrate from the site they come from, which is characterized by high clay content and possibly microorganisms which have a symbiotic relationship with the species.
A case series of uterine rupture: a continuing cause of maternal and fetal morbidity!

Background: Uterine rupture is defined as a full-thickness separation of the uterine wall and the overlying serosa. It is a rare peripartum complication associated with severe maternal and neonatal morbidity and mortality. The objective of this study was to review the incidence of ruptured uterus and evaluate associated risk factors, maternal and fetal complications. Methods: 14 case notes were reviewed for every patient with a ruptured uterus for a period of 4 years, from January 2012 to December 2015. Results: 79% patients had uterine rupture while in labour. Three patients were not in labour (two had a spontaneous rupture at 28/40 and 33/40 weeks respectively and for one patient it was found during an elective C/S). Two out of five patients with 2 previous C/S ruptured at 28 and 33 weeks respectively. Two or more C/S were associated with increased risk of prelabour rupture uterus as highlighted by the three cases. Conclusions: Challenging diagnosis and cases of prelabour rupture may necessitate prepregnancy counselling and antenatal LUS thickness USS in certain cases.
NaDaMaNis (Nano Daun Mangrove dan Jeruk Nipis sebagai Pasta Gigi Herbal Antibakteri)

Kesehatan mulut dan gigi tidak kalah pentingnya dengan kesehatan bagian tubuh yang lain. Karies gigi adalah penyakit infeksi pada gigi yang disebabkan oleh Streptococcus mutans. Pasta gigi yang memiliki aktivitas antiplak dan antimikroba sangat dibutuhkan untuk mencegah pertumbuhan mikroorganisme penyebab karies gigi. Penggunaan bahan herbal yang memiliki kemampuan sebagai antibakteri yaitu daun mangrove dan jeruk nipis. Tujuan penelitian ini adalah mengetahui proses pembuatan sediaan pasta gigi herbal, uji sifat fisik pasta gigi herbal, dan mengetahui uji antibakteri pada sediaan pasta gigi herbal dari daun mangrove dan jeruk nipis. Metode yang digunakan dalam penelitian pembuatan sediaan pasta gigi herbal yaitu metode eksperimental trial and error dengan penambahan ekstrak daun mangrove yang dijadikan dalam bentuk nanopartikel dengan hasil uji Particle Size Analyzer sebesar 10,9 nm dan ekstrak jeruk nipis ke dalam sediaan pasta gigi herbal sebagai antibakteri. Ekstrak daun mangrove dan ekstrak jeruk nipis didapatkan dari proses ekstrasi metode maserasi menggunakan pelarut etanol 96%. Formulasi sediaan pasta gigi menggunakan variasi nano ekstrak daun mangrove dan ekstrak jeruk nipis sebanyak 1 gram, 1,1 gram, dan 1,2 gram. Hasil formulasi terbaik dari sediaan pasta gigi herbal antibakteri adalah formulasi 3 dilihat dari hasil uji evaluasi sediaan meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji stabilitas, uji antibakteri, dan uji Ca dalam saliva. Kata kunci: pasta gigi, daun mangrove, jeruk nipis
Primary Percutaneous Coronary Interventions in Cancer Patients

Cardiovascular disease and cancer increasingly coexist, therefore optimum management is required in order to treat the underlying malignancy and to reduce morbidity and mortality associated with cardiovascular diseases. Primary PCI in patients with active cancer and coronary artery disease presents particular challenges for clinicians. Special considerations include radiation and chemotherapy-induced vascular damage, primary or secondary thrombocytopenia, presence of coagulopathies, vascular access complications and increased risk of stent thrombosis. Although PCI is performed in a minority of cancer patients, it is not associated with worse long‐term cardiovascular outcomes. Conservative management of ACS in cancer patients offers poor survival rates. In the majority of cancer patients with acceptable prognosis or cancer survivors, well planned and performed PCI is probably the best option.
Protective effect of grifolin against brain injury in an acute cerebral ischemia rat model

Purpose: To evaluate the protective effects of grifolin against brain injury in an acute cerebral ischemia rat model. Methods: Rats were assigned to five groups: control, negative control, and grifolin (50, 100, and 200 mg/kg, p.o.) treated groups, which received the drug for 2 weeks. All the animals were sacrificed at the end of the protocol, and tissue homogenates were prepared from isolated brain tissue. Glutathione peroxidase (GPX), superoxide dismutase (SOD), malondialdehyde (MDA), and nitric oxide (NO), as oxidative stress indicators, were determined for the tissue homogenates of the ischemic rats. Inflammatory mediators (cytokines and nuclear factor kappa B p65, NF κB), DNA damage, and ATP and caspase 3 levels in the tissue homogenates were also assessed. Results: Treatment with grifolin increased SOD and GPX significantly and decreased MDA and NO levels in tissue homogenates of the cerebral ischemic rats compared with those in the negative control group ( p < 0.05). Treatment with grifolin also attenuated the altered levels of inflammatory mediators (cytokines and NF-κB), caspase 3, and ATP levels in the tissue homogenate of cerebral ischemic rats ( p < 0.05). The results of comet assay on the tissue homogenate suggest that treatment with grifolin reduced or prevented damage. Conclusions: The results show that treatment with grifolin protects against neuronal damage in acute cerebral ischemic rats via its anti-inflammatory and anti-oxidant properties. Keywords: Neuroprotection, Cerebral ischemia, Brain injury, DNA, Grifolin, Anti oxidant
Prehabilitation and its relevance to patient outcome

Prehabilitation is defined as the process of enhancing an individual’s functional capacity to enable him or her to withstand a forthcoming stressor e.g. major surgery. Its use in sports refers to the form of strength training required to prevent injuries before they happen and has the origin from the words “pre”+ “rehabilitation” and is probably the source from where the word moved into medical jargon. In medical practice prehabilitation refers to the process of “enhancing a patient’s functional capacity before surgery with the aim of improving post-operative outcome”.
The process of setting micronutrient recommendations.

Micronutrient recommendations are derived using a risk analysis paradigm. This commonly involves a process of three, separate yet interconnected, risk activities to assess, communicate and manage risk. Research has suggested a lack of transparency in the application of risk analysis activities during the process of setting micronutrient recommendations. The aim of this thesis was to identify the practical challenges of communicating risk internally - between experts and/or stakeholders - and understand the implications of these challenges for achieving a transparent micronutrient risk analysis process. A series of three international qualitative studies were conducted which employed narrative literature, interview and case study methods. Research was primarily related to the process of setting folate and vitamin D dietary reference values (DRV) or regarding the implementation of DRV via food-based dietary guidelines (FBDG). Results identified challenges to the communication of risk across all three risk activities (risk assessment, risk communication and risk management). These challenges included clarifying the terms of reference between risk assessors and risk managers during the DRV problem formulation stage; equivocal lay involvement and ambiguous handling of uncertain (unknown, indefinite, unreliable) evidence during DRV risk assessment; inconclusive evidence of successful risk communication (FBDG); and ubiquitous inconsistency of DRV/FBDG terminology throughout risk analysis. Findings suggested specific areas where effective (valid and credible) internal communication of risk is required between risk experts and/or stakeholders involved in the risk analysis process. This is distinct from, and in addition to, traditional risk communication activities conducted with the general public/stakeholders outside the risk analysis process. Overcoming the challenge of communicating risk is a prerequisite for achieving a transparent micronutrient risk analysis, and can aid future debates on the pre-eminent micronutrient recommendation setting process.