Miracle-dz/UniFAR-FTUs huggingface dataset:
Different Perspectives on the Boomerang: How Adult Daughters and their Parents Experience the Move Back Home

Though the phenomenon of young adults moving in with their parents is not a new one, it is one that has certainly become more common in recent decades. A new life stage of “emerging adulthood” has become the norm, in which young adults delay marriage and career jobs in order to pursue other goals. This stage is, in part, marked by fluidity in residence. Yet even as a growing number of “boomerang kids” move back in with their parents, there is a gap in the research regarding this phenomenon’s effect on various parts of the family system. This study set out to address this gap by comparing separate interviews from young adult boomerangs and their parents. Findings suggest a disparity between parental and young adult opinions on a variety of topics, most notably: expected household responsibility, parent/child closeness, loss of autonomy, and appreciation. However, similarities emerged regarding the parental home as a safe haven, the arrangement as providing financial security, and the fact that all adult children reported being ready to move out. Ideally, the findings presented here will help illuminate both the similarities and disparities in the experiences of parents and their young adult children who return after launch, in order to increase empathy and promote a healthy family system.
Vécu de "l'affaire Mediator®" par le médecin généraliste et conséquences sur sa pratique de prescription et sur sa relation au système de pharmacovigilance : étude qualitative auprès de médecins généralistes picards

Introduction : Le benfluorex a ete largement prescrit hors AMM en France et a montre une defaillance de l’ensemble des acteurs du circuit du medicament, notamment du systeme de pharmacovigilance. Il s’agissait, a partir du vecu de l’affaire par le medecin generaliste, d’explorer les changements eventuels dans sa pratique de prescription, et dans son rapport au systeme de pharmacovigilance. Methode : Une enquete qualitative par entretiens semi-diriges a ete realisee aupres de 14 medecins generalistes jusqu’a saturation des donnees. Resultats : Cette etude a retrouve des ameliorations des pratiques de prescription, notamment hors indication, des medecins generalistes, malgre des elements motivant encore un mesusage des medicaments. Les medecins avaient conscience de la necessite de notifier les effets indesirables medicamenteux en pharmacovigilance mais exprimaient des reticences envers cette notification. Discussion : Cette etude a mis en relief plusieurs themes : un risque persistant de mesusage des medicaments, qui pourrait a terme favoriser l’emergence de nouvelles affaires identiques a celle du Mediator®, et une amelioration necessaire de la participation des medecins generalistes au systeme de pharmacovigilance. Conclusion : Des campagnes de sensibilisation des medecins generalistes aux risques lies a la prescription hors AMM et aux moyens disponibles de notification des effets secondaires medicamenteux sembleraient interessantes.
The Effect of Eight-Week Combined Exercise Training Program with Sweet Almond Supplementation on Plasma Levels of Leptin and Orexin in Overweight Women

Background: The purpose of this study was to investigate the effect of an eight-week combined exercise training program with sweet almond supplementation on plasma levels of leptin and orexin in overweight women. Methods: This research was a quasi-experimental study. The statistical population consisted of 60 overweight women with a body mass index (BMI) of 25-30 kg/m2 who were randomly divided into four groups of training, training-sweet almond supplement, supplement, and control. The participants participated in three training sessions weekly and consumed sweet almond supplementation for eight consecutive weeks. The participants' blood samples were taken 24 hours before the first session and after the last session, in a 12-hour fasting state. Liptin concentrations were measured using Pishtaz Teb Inc. kits. Orexin levels were determined through enzymatic method using the Virro Inc. kit. A two-way repeated measures ANOVA was conducted to analyze the inter- and intra-group variance. The overall alpha significance level was set at P ≤ 0.05 for all the statistical analyses. Results: Eight weeks of combined exercise training with sweet almond supplementation Showed a significant reduces in serum level leptin concentration and increased the plasma orexin levels. Conclusion: According to the results of the present study It can be used from combined training and sweet almonds to reduce appetite and lose weight in overweight women.
Evaluation of Jones County's Alternative School program

The Jones County Alternative School Program (JCASP) was established during school year 1995-1996 and was designed for students who chronically interfere with their own learning and/or the education process of others and who require additional attention and structure beyond that provided through a traditional education program. In this study, high school students were studied with regard to academic achievement, attendance, self-concept, discipline, and goal setting opportunities before and after attendance at the alternative school. Data were gathered from school years 2000-2001, 2001-2002, 2002-2003, 2003-2004 and 2004-2005 from student records, surveys, observations, and stored computer records. Analysis of the data showed a statistically significant difference in the attendance rate, academic achievement, and discipline referrals of students who had been previously enrolled in the JCASP. Data revealed an improvement in student grade point average, attendance rate and discipline. However, no statistically significant differences were found in their self-concept or perceived opportunities for goal setting.
EEG etter søvndeprivering hos pasienter med epilepsisuspekte anfall

Background. The purpose of this study was to investigate to what extent sleep deprivation provokes epileptiform discharges in EEG in patients with suspected epilepsy. Material and methods. Data from 189 adults and children with unspecified seizures who had had EEG after sleep deprivation were evaluated retrospectively. Previous standard EEGs were without epileptiform discharges. The patients’ final diagnosis were collected from the medical records. Results. 13 % of the patients demonstrated epileptiform activity in their sleep deprivation EEG, and significantly more epileptiform activity was found in patients with generalized tonic-clonic seizures and absences. None of the patients with a history of syncope showed epileptiform activity. The activation rate was higher in patients with an abnormal standard EEG compared to those with a normal standard EEG. The sensitivity of sleep deprivation EEG in this study was 35 %, specificity 98 % and positive predictive value 92 %. Interpretation. Sleep deprivation EEG seems to have greatest diagnostic value in patients with generalized tonic-clonic seizures, absences and abnormal standard EEG. Formålet med undersøkelsen var å finne ut om og eventuelt i hvilken grad søvndeprivering fremkaller epileptiform aktivitet i EEG hos pasienter med epilepsisuspekte anfall. EEG-journalene til 189 voksne og barn som hadde vært til EEG etter søvndeprivering ble gjennomgått retrospektivt. Alle hadde standard-EEG uten epileptiform aktivitet. Endelig diagnose etter såkalt søvndeprivert EEG ble registrert fra pasientens hovedjournal. 13 % av pasientene hadde epileptiform aktivitet i søvndeprivert EEG, med høyest andel hos dem med generelle kramper og absenser. Ingen av synkopepasientene hadde epileptiform aktivitet i søvndeprivert EEG. Andelen epileptiform aktivitet i søvndeprivert EEG var høyest hos pasienter med patologisk standard-EEG. Sensitiviteten av søvndeprivert EEG var i denne studien 35 %, spesifisiteten 98 % og positiv prediktiv verdi 92 %. Søvndeprivert EEG har størst diagnostisk verdi hos pasienter med generelle kramper, absenser og patologisk standard-EEG.
Intrahepatic Cholestatic Hepatitis after Ajmaline and Flecainide Application in a Patient withVentricular Tachycardia and Cyp2d6 Polymorphism

Intrahepatic cholestatic hepatitis is a rare but therapy-limiting side effect of antiarrhythmic drugs, in literature only few reports are related to the subscription of ajmaline [1-3]. As potential causes for development of intrahepatic cholestatic hepatitis drug-triggered autoimmune reactions as well as direct toxic effects are recently discussed. However, the mechanism of this severe hepatic side effect remains unclear.
Examination of Neutrophil, Platelet, Monocyte-Lymphocyte Ratios in Adolescents with Bipolar Disorder-Manic Episode and Depression

How to cite this article: Usta MB, Aral A, Sahin B, Bozkurt B, Karabekiroglu K. Examination of neutrophil-, platelet-, and monocyte-lymphocyte ratios in adolescents with bipolar disorder-manic episode and depression. Dusunen Adam The Journal of Psychiatry and Neurological Sciences 2019;32:328-333. Examination of neutrophil, platelet, and monocytelymphocyte ratios in adolescents with bipolar disorder-manic episode and depression
EFFECT OF SIMVASTATIN ON RENAL FUNCTION AND IMPAIRMENT FOLLOWING TO THE UNILATERAL URETHRAL OBSTRUCTION IN RAT

Background: Obstructive uropathy indicates any possible obstruction in urinary flow. At the end stage, obstruction cause changes in the renal function. Competitive HMG-CoA reductase inhibitors, like simvastatin, decrease serum lipid level. It is shown that statines have organ protective effects following different impairments. The aim of this study was the evaluation of simvastatin effect on renal function and impairment following unilateral urethral obstruction in rat. Materials and Methods: In this experimental study 50 adult male rats (Sprague-Dawley), subjected to unilateral urethral obstruction (UUO), were divided randomly into five groups including control, UUO, UUO/SIM (simvastatin), Sham-operated and sham/SIM group. The control group received the drug solvent for 15 days. In UUO group, animals received the drug solvent postoperatively. Animals in UUO/SIM group received simvastatin (2 mg/kg/twice a day) for 15 days (starting one day before operation). Sham and sham/SIM groups were subjected to surgery without urethral obstruction. Blood samples were collected on day 0, 3, 7 and 14 after surgery to measure creatinine, urea and cholesterol levels of the serum. Rats were sacrificed for histopathological evaluation on day 14. Using one-way ANOVA analysis, Tukey's post hoc and student t-test, data were analyzed. Result: The evaluation of biochemical parameters showed that, compared to control the group, the level of creatinine, urea and cholesterol in the UUO group were significantly increased 7 and 14 day postoperative (P Conclusion: Our findings showed that the urethral obstruction decreased renal function and caused severe impairment in renal tissue. Simvastatin decreased the tissue lesions induced by the obstruction of urethra. Of course, the protective effects of simvastatin in humans need more research.
Propofol versus midazolam in sedation for upper gastrointestinal endoscopy

Background: Upper gastrointestinal endoscopy [either diagnostic or therapeutic] is widely practiced under conscious sedation. However, the standard sedative agent or drug combination is not yet well established.Aim of the work: Comparison between propofol-fentanyl and midazolam-fentanyl for sedation in upper gastrointestinal endoscopy.Patients and methods: Sixty patients from those scheduled to undergo upper gastrointestinal endoscopy at the Gastrointestinal Endoscopy Unit were included. Patients were divided into two equal groups: propofol-fentanyl and midazolam fentanyl. The Anesthetist scheduled to perform the procedures was oriented by the drug, while patients did not know the sedating drug. Prior to the procedure, a clinical history and physical examination was carried out, and throughout the procedure the patient was monitored for blood pressure, heart rate, respiratory rate, and oxygen saturation. Both groups were compared regarding time to recovery, patient satisfaction, physician satisfaction and adverse events.Results: Recovery time was significantly shorter, patient and physician satisfaction scores were significantly higher among propofol group. On the other side, systolic blood pressure was significantly lower in propofol group at midpoint and recovery times, while oxygen saturation was significantly reduced in midazolam group at intermediate point of the procedure. Finally, hypoxia was significantly higher among midazolam group [reported in 20.0%], versus [none] in propofol group. No other adverse events were encountered.Conclusion: Propofol is better sedative than midazolam for upper gastrointestinal endoscopy. Thus, it should be used as a first-line drug in sedation in our endoscopy units.
Clinical judgment and care behavior by nurses in postoperative pain management

The objectives of this descriptive research were: to investigate the clinical judgment of nurses regarding postoperative pain, their caring behaviors in postoperative pain management, and the relationship between nurses’ clinical judgment regarding postoperative pain and nurses’ caring behaviors in postoperative pain management. A sample of 260 professional nurses who worked in the surgical wards of two regional and two provincial hospitals in southern Thailand under the Ministry of Public Health administration were used in the study. The content of the instruments were all validated. The internal consistency reliability coefficients of the two parts of nurses’ caring behavior in the postoperative pain management questionnaire were 0.72 and 0.78 and for nurses’ clinical judgment regarding postoperative pain questionnaire was 0.85. The data were analysed using descriptive statistics and Spearman’s Rank Correlation. The results indicated that subjects rated nurses’ clinical judgment regarding postoperative pain as ‘good’ with a mean of 3.98 (score 1-5). It was also found that the aspect in which nurses made the best clinical judgment was in understanding of the patients with a mean of 4.19. Overall, the subjects rated nurses’ caring behavior in postoperative pain management as ‘good’ with a mean of 34.26. (total score = 37). There was no significant relationship between nurses’ clinical judgment regarding postoperative pain and nurses’ caring behaviors in postoperative pain management. This finding may be partly due to the restricted range of scores on these two questionnaires. A replication study is recommended and further development of the instruments, particularly nurses’ clinical judgment questionnaire is suggested.
The Developmental Origins of Health and Disease (DOHaD)

For years many have believed that genetic heritage defined one’s destiny, if an individual would grow to be healthy, or if he or she would suffer from chronic illness or cancer. Recent scientific evidence and the field of epigenetics has proven this to be untrue. Certainly, the DNA sequence and the genetic code are fixed; but the field of epigenetics has shown how methylation and other chemical modifications of the genome directly influence the production of proteins that can alter the phenotype of an organism. This article will lay out the supporting research, the details on how the internal and external environments influence genetic function, and will allow the reader to develop an action plan necessary to influence the genetic code, with the goal of then moving the individual toward optimal health. These research details will enable health care professionals in every field of medicine to work with patients on positively influencing the genetic output in order to improve the quality of life and longevity.
The Role of Lipids in Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma is the fastest growing cause of cancer-related mortality worldwide, with few treatment options and a 70% recurrence rate. This trend is driven largely by the recent surge in incidence of metabolic syndrome, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis. Given the central role of the liver in lipid homeostasis, altered hepatic lipid metabolism has been identified as a contributing factor to hepatocellular carcinoma. Neoplastic cells are highly dependent on lipid metabolism as a source of energy and to support rapid cell division, and fatty acid derivatives play key roles in cell signaling. Aberrant expression of liver fatty acid–binding protein and changes in the ratio of saturated to unsaturated triacylglycerols have been shown to be associated with disease severity and subtype. This chapter focuses on metabolic reprogramming and dysregulation of lipid metabolism as hallmarks of hepatocellular carcinoma.
A Meta-Analysis of the Effects of Exercise Programs on Glucose and Lipid Metabolism and Cardiac Function in Patients with TypeII Diabetes Mellitus

PURPOSE This study was a systematic review and meta-analysis of the effects of exercise programs in patients with type II diabetes mellitus. METHOD Two investigators systematically searched and reviewed English articles from PUBMED from 1988 to 2004, selecting randomized controlled trials on structured exercise programs for DM patients. Out of 87 studies identified, a meta analysis was done for eleven studies which satisfied inclusion criteria and focused on glycemic indices, lipid indices, and cardiac function indices. RESULTS The means and standard deviations were compared for experimental groups that received exercise-only or exercise and diet programs and control groups that received no intervention or only diet education. The groups were considered homogeneous as the p value of the Q score in each variable group was over 0.05. The experimental groups demonstrated a moderate positive effect on HbA1c and VO2max (d=0.55 & 0.5), and a small positive effect on fasting blood glucose and cholesterol (d=0.38 & 0.27) compared to the control groups. HDL and LDL cholesterol levels, however, showed a very low positive effect (d=0.11 & 0.12) in the experimental groups. Aerobic exercise was more beneficial than resistance exercise on HbA1c (d=0.59 vs 0.28) in the groups. CONCLUSIONS Regular exercise has a positive effect on HbA1c, fasting blood glucose, total cholesterol, HDL cholesterol, LDL cholesterol, and VO2max in Type 2 diabetic patients.
Trajectories of Burden and Depression in Caregivers Following Traumatic Injury: The Role of Resilience

As part of an effort to understand psychological consequences among family members of patients sustaining a traumatic injury, medical research has turned to the role of resilience – or the ability to bounce back from and maintain psychological well-being in the wake of an adverse event— in mitigating the potential distress (i.e., depression and burden) of caregiving (Bonanno, 2004; Roberson et al., under review). This study sought to examine the ability for trait-resilience to predict trajectories of distress over the course of a year among 124 family members and loved ones of patients admitted to a Level I Trauma Center. A cross-lagged path model examining resilience, burden, and depression at baseline, 3, 6, and 12 months after injury showed that, while depression strongly predicted later burden, resilience was not a significant predictor of either outcome in the model. When depression and burden were subjected to a person-centered analysis (i.e., latent growth curve analysis), two major classes were identified: caregivers with high, chronic distress (33% of the sample) and low-moderate distress that declined over time. A three-class solution for caregiver burden further identified a moderate, increasing trajectory class. Predictive discriminant analyses revealed that trait-resilience was a major differentiating trait between class membership (rs = .23 for depression; rs = .32 for burden); further, presence of PTSD symptoms at baseline, gender, and history of depression were shown to be strong factors in distinguishing class membership across both outcomes. This study helps shed insight into the well-being of caregivers in the wake of a loved one's traumatic injury, in addition to possible identifying risk factors while patients are still admitted in the ICU. Lastly, the study provides alternatives for analyses that focus on longitudinal outcomes, particularly person- vs. variable-centered solutions.
Temporomandibular Disorders: An Evidence-Based Approach to Diagnosis and Treatment

Daniel M. Laskin, D.D.S., M.S.; Charles S. Greene, D.D.S.; William L. Hylander, D.D.S., Ph.D., editors, Hanover Park, IL: Quintessence Publishers, 2006. 540 pp., illustrated $158.00 hardcover ISBN 0-86715-447-0 This new textbook on temporomandibular disorders (TMD) is edited by three true veterans
Achieving Academic Success After School: A Randomized Evaluation of the Higher Achievement Program 1

We conduct a RCT of a high-quality, comprehensive, and time-intensive after-school and summer supplemental-education program targeted at students in middle school. We find that the program significantly increases students’ problem solving and reading comprehension scores two years after baseline. The program also causes students to reassess their perceptions of their own academic abilities. We find no evidence that the program improves test scores after one year or that the program changes students perceptions of the support they receive from adults or their peers. We also do not find that the program improves students’ test scores or other outcomes over the summer of 2010. However, their test scores also do not decrease over the summer as they do for many students. Finally, we find evidence that the program increases students’ desire to attend competitive area high schools rather than their local public schools. Surprisingly, the program also increases the rate at which students report misbehaving.
Nonparametric volatility change detection

We consider a nonparametric heteroscedastic time series regression model and suggest testing procedures to detect changes in the conditional variance function. The tests are based on a sequential marked empirical process and thus combine classical CUSUM tests from change point analysis with marked empirical process approaches known from goodness‐of‐fit testing. The tests are consistent against general alternatives of a change in the conditional variance function, a feature that classical CUSUM tests are lacking. We derive a simple limiting distribution and in the case of univariate covariates even obtain asymptotically distribution‐free tests. We demonstrate the good performance of the tests in a simulation study and consider exchange rates as a real data application.
Kindesmisshandlung: interdisziplinärer Kinderschutz

Zusammenfassung Die zunehmende Aufmerksamkeit für das Thema Kindesmisshandlung hat in den letzten Jahren zu grundlegenden Veränderungen geführt. Das Bundeskinderschutzgesetz und die neue S3+-Kinderschutzleitlinie (KSL) der AWMF bieten effektive Mittel gegen den Missbrauch. Fundiertes Wissen über das klinische Bild, die beteiligten Akteure und die Gesetzeslage sind Voraussetzungen, um medizinischen Kinderschutz effektiv gestalten zu können.
Biomarkers in neurocritical care

Since the 1950s, interests in biomarkers of neuronal injuries have increased significantly. Most of the earliest work involves studies in traumatic brain injury (TBI) and cerebral ischaemia. In 1976, Rudman et al. published a classic study on cerebrospinal fluid (CSF) cyclic adenosine monophosphate levels in TBI as a putative marker of the depth of coma after injury. [2,3] In 1988, Vaagenes et al. studied the levels of brain creatine kinase (CK) in CSF in dogs after cardiac arrest and shows that peak activity at 48–72 h post‐arrest correlated with poor outcome. [4] This was translated to human 6 years later and found that the increase in CK activity in CSF reflects permanent brain damage. [5] Despite the ubiquitous use of CK to investigate cardiac injury, it had never been part of the routine blood work for neurological injury.