Miracle-dz/UniFAR-FTUs huggingface dataset:
Using information technology productively: practices and factors that enhance the success of IT

This paper explores the factors and practices that influence the benefits provided by IT. The study uses the results of a questionnaire survey completed by the head of the IT department of 81 Australian organisations. To ascertain the level of success, the benefits of IT on 16 measures of organisational performance were evaluated. A hierarchical cluster analysis was conducted to subdivide these performance measures into manageable groups. Four sets of factors were examined: (1) Profile of the IT department, including budget and number of levels in the IT department, (2) Role of the IT department in the organisation's strategic planning, (3) Scope of issues addressed within the IT strategy, and (4) Profile of the organisation, including number of employees, annual sales, and principal ownership. Canonical correlation analysis was carried out to investigate the relationship between these practices and IT success. The findings clearly reveal that benefits are generally enhanced by maximising the role of IT in the organisation's overall strategy and by augmenting the number of issues addressed within the IT strategy. Increasing the investment into IT and the number of levels within the IT department enhanced quality and the value of products and services, but impeded the availability of stock (i.e. inventory levels of parts). Finally, organisational size and principal ownership did not appear to influence the benefits of IT.
Cyclic Adenosine 3 , 5-Monophosphate Analogues Modulate Rat P $ acental Cell Growth and Differentiation 1

Cyclic adenosine 3’,S’-monophosphate (cAMP) has been implicated in the control of placental function. The present investigation was designed to evaluate the actions of cAMP analogues on the control of rat placental development. Two model systems were used to assess the actions of cAMP in the placenta: 1) a rat placental cell line and 2) rat labyrinth placental explants. Elevation of intracellular cAMP via treatment with cAMP analogues, 3-isobutyl-J -methylxanthine, forskolin, or cholera toxin inhibited placental cell DNA synthesis whereas treatment with an analogue to cyclic guanosine 3’,5’-monophosphate was without effect. The inhibitory actions of dibutyryl cAMP on DNA synthesis were at least partially reversible and were not the result of metabolic toxicity. Dibutyryl cAMP had dramatic effects on the organization and morphology of placental cells growing in vitro and diminished the ability of the placental cells to grow following transplantation into allogeneic hosts. Dijferentiatio n-associated characteristics of rat placental cells were also affected by cAMP, cAMP analogues stimulated placental cell progesterone release and inhibited placental cell alkaline phosphatase activity. Dibutyryl cAMP had effects on placental labyrinth explants similar to its effects on the placental cell line. Dibutyryl cAMP inhibited explant outgrowth while stimulating explant release of progesterone. In summary, cAMP effectively modulates the growth and differentiation of rat placental cells in vitro.
Clinical Trials and Molecular Radiotherapy

73 This issue of “WJNM” is heavily biased in favor of the use of radionuclides in molecular radiotherapy. This is of course appropriate, as the journal has strong links with the World Association for Radionuclide Molecular Therapy (WARMTH). We, the editorial team, are very proud that many authors from institutions around the globe choose this journal to publish their results and share possibilities for treating patients with a range of benign and malignant conditions. Newer radionuclides such as Re-188 and Lu-177 are being coupled to new pharmaceuticals, and these enable an increasing range of therapies to be developed. However, there remains a real issue. In the hands of enthusiastic nuclear medicine physicians, many patients receive effective treatments targeted to their particular clinical problem with minimal toxicity, functioning as truly personalized medicine, but worldwide this only applies to a minority of patients suffering from any particular disease. The use of molecular radiotherapy is still not universal. For many molecular radiotherapy techniques, the chance of a patient having access to a particular treatment may be down to nothing more than luck. They are fortunate if they are born in a particular country or even a particular city and are looked after by a doctor who has knowledge of molecular radiotherapy techniques, who is willing to refer to a nuclear medicine physician trained to administer that treatment. Surprisingly, it is not just a matter of money. In many cases, a patient living in one of the world’s richest economies such as the USA or Japan may have as much chance of referral as a patient living in Togo or Bhutan.
Historic demography and phylogenetic relationship of Euthynnus species based on COI sequence analyses

Euthynnus species are epipelagic migratory tuna species, with global distribution. They occur in the open waters but usually remain close to the shoreline. In present study, historic demography and phylogenetic relationship of Euthynnus species were examined using sequence data from portions of the mitochondrial COI gene. A total of 35 sequences were retrieved from NCBI. Mismatch distribution analyses suggested a late Pleistocene population expansion of E. affinis and E. alletteratus. Neutrality test for E. alletteratus fails to reject the null hypothesis of neutral evolution while COI sequences of E. affinis are found to be at genetic equilibrium. Phylogenetic analysis suggest that E. alletteratus is the most ancestral species while E. affinis is more closely related to E. lineatus than E. alletteratus.
Repairing iatrogenic root perforations.

BACKGROUND Post preparation is an integral part of restoring endodontically treated teeth in indicated cases. Iatrogenic perforation of the root can result from preparing post space and can severely compromise the prognosis of the tooth. CASE DESCRIPTION Two years after a patient's maxillary lateral incisor was restored with a post-retained composite resin, he went to a dental school emergency clinic with a chief complaint of soft-tissue swelling adjacent to the tooth. The authors took a periapical radiograph that revealed evidence of a circumscribed radiolucent lesion associated with the distal midroot area and a periapical radiolucency. Based on the radiograph, the authors suspected that the canal preparation for the post and the post placement had perforated the root at the base of the post. CLINICAL IMPLICATIONS The authors used a combined surgical and orthograde approach with a biocompatible restorative material and a clear, plastic light-transmitting post to repair the iatrogenic perforation.
Role of MT‐MMPs and MMP‐2 in pancreatic cancer progression

Activation of matrix metalloproteinase‐2 (MMP‐2) by the membrane‐type matrix metalloproteinases (MT‐MMPs) has been associated with tumor progression. In the present study, we examined the role of MMP‐2 and its activators MT1‐MMP, MT2‐MMP and MT3‐MMP in pancreatic tumor cell invasion and the development of the desmoplastic reaction characteristic of pancreatic cancer tissues. Northern blot analyses revealed that transcript levels of MT1‐MMP and MT2‐MMP, but not MT3‐MMP, were enhanced in pancreatic cancer tissues (n = 18) compared with both chronic pancreatitis (n = 9) and healthy pancreas (n = 9). A good correlation was found between MT1‐MMP and both MMP‐2 expression (p < 0.01) and activity in pancreatic cancer tissues. In addition, expression and activation of MMP‐2 were strongly associated with the extent of the desmoplastic reaction in pancreatic cancer tissues. Invasion assays showed a good correlation between MMP‐2 expression and activity and the invasive potential of pancreatic cancer cell lines. In cell lines with high levels of MMP‐2 expression and activity, the MMP inhibitor Batimastat led to significant reduction of the number of invading cells. Our results suggest that MT1‐MMP is involved in the progression of pancreatic cancer via activation of MMP‐2. MMP‐2 itself plays an important role in tumor cell invasion and appears to be associated with the development of the characteristic desmoplastic reaction in pancreatic cancer. Int. J. Cancer 85:14–20, 2000. © 2000 Wiley‐Liss, Inc.
An Innovative Risk Assessment Tool for Prospective Risk Analysis to Improve the Quality in Health Care: The Bow-Tie

In healthcare, serious adverse events and medical errors can easily occur jeopardizing patient safety and continuity of treatment [1]. However, studies have revealed that identifying risks and working on analyzing and mitigating them, have proven to lower down undesirable and preventable healthcare associated events [2]. The Health and Safety Executive defines hazard as ‘’ anything that may cause harm, such as chemicals, electricity, working from ladders, an open drawer etc.’’ and risk as ‘’the chance, high or low, that somebody could be harmed by these and other hazards, together with an indication of how serious the harm could be’’ [3]. In healthcare, there are several events that could be prevented such as falls in hospitals, surgical site infections, drugs’ side effects and post-operative complications and having a risk assessment model in place would help deployment of barriers to prevent the occurrence of these events.
On the Standardization of Total Prostate-Specific Antigen: an Exercise with Two Reference Preparations

Abstract In this study, 112 serum samples were analyzed for total prostate-specific antigen with three well-established assays i.e. Tandem R and Tandem E (both from Hybritech Inc., San Diego, USA) and Prostatus Free/Total from Wallac Oy, Turku, Finland. Thirty-two samples were collected from prostate cancer patients, 32 from patients with benign prostate hyperplasia and 48 from men participating in a screening study for prostate cancer. The aim of the study was to compare the results before and after recalculation with the data obtained with two reference preparations for total prostate-specific antigen: Stanford 90:10 PSA Calibrator and Certified Reference Material 613 Prostate-Specific Antigen. Comparing the actual results revealed almost perfect correlations between Tandem R and Tandem E and between both Tandem assays and Prostatus. We observed statistically significant differences in accuracy between Tandem R and Tandem E: y(Tandem E)= 1.05 × (Tandem R)+0.07, and between Tandem E and Prostatus: y(Prostatus)= 0.94 × (Tandem E)+0.02 In both comparisons prostate-specific antigen values ranged from 0–40 μg/l. Recalculation with both reference preparations did not solve these discrepancies. One exception was the combination Tandem R and Tandem E. The application of either reference preparation solved the differences in accuracy here. In conclusion, even after recalibration, assays for total prostate-specific antigen are still not completely interchangeable.
Acetylcholinesterase activity rises in rat cerebrospinal fluid post‐ictally; effect of a substantia nigra lesion on this rise and on seizure threshold

1 The activity of acetylcholinesterase (AChE) in the cerebrospinal fluid (CSF) of rats increased by 53% following an electroconvulsive shock (ECS) while non‐specific cholinesterase (nsChE) activity was unchanged. 2 A flurothyl‐induced seizure failed to elicit a change in the AChE activity of CSF. 3 A bilateral lesion of the substantia nigra pars reticulata abolished the rise in AChE activity in the CSF but did not diminish the increase of seizure threshold which follows a convulsion. 4 These data suggest that AChE is released from the substantia nigra following a seizure but indicate that the change is not associated with the rise in seizure threshold which occurs.
p-Curve and Effect Size

Journals tend to publish only statistically significant evidence, creating a scientific record that markedly overstates the size of effects. We provide a new tool that corrects for this bias without requiring access to nonsignificant results. It capitalizes on the fact that the distribution of significant p values, p-curve, is a function of the true underlying effect. Researchers armed only with sample sizes and test results of the published findings can correct for publication bias. We validate the technique with simulations and by reanalyzing data from the Many-Labs Replication project. We demonstrate that p-curve can arrive at conclusions opposite that of existing tools by reanalyzing the meta-analysis of the “choice overload” literature.
Fibroblast Growth Factor 23, Hepatocyte Growth Factor, Interleukin‐6, High‐Sensitivity C‐Reactive Protein and Soluble Urokinase Plasminogen Activator Receptor. Inflammation Markers in Chronic Haemodialysis Patients?

Sera from 84 haemodialysis (HD) patients and 68 healthy blood donors were analysed with commercially available ELISA techniques for fibroblast growth factor 23 (FGF‐23), hepatocyte growth factor (HGF), interleukin‐6 (Il‐6), high‐sensitivity C‐reactive protein (hs‐CRP) and soluble urokinase plasminogen activator receptor (suPAR), to find a possible correlation of FGF‐23 and HGF with the earlier recognized inflammatory markers Il‐6 and hs‐CRP or suPAR. All patients studied had significantly elevated levels of FGF‐23, HGF, hs‐CRP and suPAR as compared to the controls. Il‐6 and hs‐CRP correlated for patients (R = 0.6) as well as for patients and controls altogether. Ln (natural logarithm) of HGF correlated weakly with Ln Il‐6 and Ln CRP (R 0.28–0.37). Ln FGF‐23 correlated only with Ln HGF (r = −0.25) in controls. Ln HGF correlated with ln suPAR (r = 0.6) in both patients and controls. Although elevated as compared to controls, we found no correlation of FGF‐23 with the recognized inflammatory markers Il‐6, hs‐CRP, nor HGF or the new marker suPAR in HD patients. Ln HGF correlated with Ln Il‐6, Ln CRP and Ln suPAR. Although probably involved in vessel disease, FGF‐23 and HGF may play other roles than acting in inflammatory vessel disease in HD patients. Further studies are necessary to evaluate the role of these immunological markers in chronic haemodialysis patients with atherosclerosis.
Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw 110 Induces the Proteasome-Dependent Degradation of the Catalytic Subunit of DNA-Dependent Protein Kinase

Herpes simplex virus type 1 (HSV-1) infection causes the active degradation of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), and this process is reliant on the expression of the HSV-1 immediate-early protein Vmw110. In this study we investigated in more detail the mechanism by which the degradation occurs, the domains of Vmw110 which are required, and whether Vmw110 is by itself sufficient for the effect. We found that proteasome inhibitors prevented the degradation of DNA-PKcs, indicating the involvement of a proteasome pathway. Furthermore, the continued activity of DNA-PK during infection in the presence of these inhibitors indicated that Vmw110 does not directly alter the enzyme activity of DNA-PKcs prior to its degradation in a normal infection. Indeed, Vmw110 was found to bind to neither the catalytic nor Ku subunits of DNA-PK. Using mutant Vmw110 viruses we show that the RING finger domain of Vmw110 is essential for the induced degradation of DNA-PKcs but that the ability of Vmw110 to bind to a cellular ubiquitin-specific protease (HAUSP) is not required. When expressed in the absence of other viral proteins, Vmw110 was sufficient to cause the degradation of DNA-PKcs, indicating that the effect on the stability of DNA-PKcs was a direct consequence of Vmw110 activity and not an indirect Vmw110-dependent effect of virus infection. Finally, the Vmw110-induced degradation of DNA-PKcs and loss in DNA-PK activity appears to be beneficial to HSV-1 infection, as virus replication was more efficient in cells lacking DNA-PKcs, especially at low multiplicities of infection.
Subgingival biofilm formation.

The human body contains numerous distinctive ecosystems that provide a unique environment for colonizing microorganisms. The periodontal pocket is one such microniche. This environment is partially sheltered from the physical shear forces in the oral cavity and contains the hard, nonshedding surfaces of the tooth root along with the shedding surfaces of gingival mucosa. The junctional epithelium, which is attached to the tooth root, is poorly differentiated, lacks keratinization and has relatively wide intercellular spaces. Consequently, junctional epithelium is permeable and allows the migration of polymorphonuclear leukocytes into the periodontal pocket. Furthermore, the tissues in the periodontal pocket are bathed in gingival crevicular fluid, a serum exudate with antioxidant properties. The initial bacterial colonizers attach to the available surfaces, as discussed elsewhere in this volume of Periodontology 2000. Later colonizers attach to the antecedent organisms and assemble into polymicrobial communities. The biofilms on the hard surfaces develop into spatially organized structures that can extend several hundred micrometers from the surface. By contrast, the epithelial surfaces, which are continually being sloughed and replenished, tend to be colonized with monolayers of microorganisms. However, several of the more pathogenic species of bacteria are able to invade the gingival cells and tissues where they can remain viable and thus constitute a nidus of infection. Interspecies adherence interactions help to shape the temporal and spatial development of the complex bacterial consortia in the gingival crevice. Bacteria within these communities encounter high cell densities and, in consequence, community living involves adaptation to higher (and unevenly distributed) levels of metabolic by-products, secondary metabolities and other secreted molecules, and to the sporadic availability of nutrients and oxygen. Bacterial inhabitants of biofilms are known to both collaborate (e.g. through nutritional cross-feeding) and compete (e.g. through production of bacteriocins) as they strive to optimize their adaptation to these environmental constraints. Bacteria can also communicate with one another through a variety of sensing and response systems based on either cell-to-cell contact or detection of soluble mediators. The signaling molecules are processed through transcriptional and post-transcriptional networks and they allow bacterial inhabitants of biofilms to coordinate activities at a group or community level. An understanding of the mechanisms of subgingival biofilm formation and development needs, therefore, to accommodate the multiple interspecies interactions that occur in polymicrobial communities.
Association Between the Density of Mossy Fiber Sprouting and Seizure Frequency in Experimental and Human Temporal Lobe Epilepsy

Summary: Purpose: If the sprouting of granule cell axons or mossy fibers in the dentate gyrus is critical for the generation of spontaneous seizures in temporal lobe epilepsy (TLE), one could hypothesize that epileptic animals or humans with increased sprouting would have more frequent seizures. This hypothesis was tested by analyzing the data gathered from experimental and human epilepsy.
Pitheciid research comes of age: Past puzzles, current progress, and future priorities

For a long time, members of the Pitheciidae were among the least studied of all Neotropical primates. But times have changed. Here, we trace the trajectory of this change and show how the articles in this special edition illustrate new knowledge and developments in our understanding of pitheciid ecology, behavior, and conservation. We propose new directions and priorities for future research, especially to ensure the effective conservation of pitheciids, and demonstrate how studies of this family are now the focus of hypothesis‐driven research that not only allows the details of this family's biology to be explored, but will allow its biology to be compared with other primate lineages. Am. J. Primatol. 78:487–492, 2016. © 2015 Wiley Periodicals, Inc.
Multivariate Outlier Detection and Treatment in Business Surveys with Missing Values.

Multivariate outlier detection based on the Mahalanobis distance with the BACON-EEM algorithm, the TRC algorithm and the ER algorithm is presented and imputation of outliers and further missing values is discussed. The methods are illustrated with a data set on Swedish municipalities. The relation between outliers, influential observations and selective editing is explored. Finally robust multivariate imputation with survey data is discussed.
Conceptual Modeling Meets Domain Ontology Development: A Reconciliation

Domain﻿ontologies﻿and﻿conceptual﻿models﻿similarly﻿capture﻿and﻿represent﻿concepts﻿from﻿the﻿real﻿ world﻿for﻿inclusion﻿in﻿an﻿information﻿system. ﻿This﻿paper﻿examines﻿challenges﻿of﻿conceptual﻿modeling﻿ and﻿domain﻿ontology﻿development﻿when﻿mapping﻿to﻿high-level﻿ontologies. ﻿The﻿intent﻿is﻿to﻿reconcile﻿ apparent﻿differences﻿and﻿position﻿some﻿of﻿the﻿inherent﻿challenges﻿in﻿these﻿closely-coupled﻿areas﻿of﻿ research,﻿while﻿providing﻿insights﻿into﻿recognizing﻿and﻿resolving﻿modeling﻿difficulties. KeywORDS Conceptual Model, Construct, Domain Ontology, Knowledge Representation, Mapping, Real World, Representation, Semantics
Towards Better Quality Assurance of the Electrical Integrity of Superconducting Accelerator Magnets

Production, assembling and operation of the superconducting (SC) accelerator magnets are substantially different than that of conventional accelerators. A properly designed set of actions addressing the electrical integrity at all stages of SC magnet lifecycle i.e. its design, testing, installation and operation are expected to shorten the commissioning phase and to extend the lifetime of the accelerator, also reducing the time for interventions during operation of magnet circuits. A coherent approach to the integrity of electrical circuits is crucial for their lifetime and safe operation. The coherent Electrical Quality Assurance (ELQA) strategy shall span the design, production, testing and operation of the accelerator. The lack of such strategy can cause the investigation and mitigation of electrical faults during final testing of magnet circuits and operation very difficult and ineffective as at this point the possibilities are significantly reduced as compared to the potential of earlier phases. This paper aims to present the main elements of the ELQA from the perspective of the electrical engineering. Presented strategy is based on several years of experience with testing of SC magnets. In the authors' opinion, the implementation of the proposed strategy at the early stage of a project is decisive to protect against and effectively cope with the electrical problems in complex systems like SC accelerator magnet circuits.
60-GHz CMOS 2 × 2 artificial-magnetic-conductor monopole on-chip antenna array for phased-array RF receiving system

This paper presents a 60-GHz CMOS 2 × 2 artificial magnetic conductor (AMC) monopole on-chip antenna array in 90-nm CMOS technology for phased-array RF receiving system. With the AMC structure, the radiation efficiency and power gain of the on-chip monopole antenna increases from 6% to 15% and from -9 to -5 dBi at 60 GHz, respectively. On-wafer beam steering measurement shows that the antenna-array main beam can scan to ±25° in the XZ plane. The chip size is 3.1 × 3.8 mm2.
Effects of a very low fat, high fiber diet on serum hormones and menstrual function implications for breast cancer prevention

Background. Low fat, high fiber dietary interventions that decrease blood estrogen levels may reduce breast cancer risk. Asian women consuming their traditional low fat, high fiber diets have lower blood estrogen levels before and after menopause and lower rates of breast cancer compared with Western women. The current controlled feeding study of premenopausal women was designed to determine the effects of a very low fat (10% of calories) and high fiber (35–45g/day) diet on blood estrogen levels and menstrual function.