Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of prednisone withdrawal on the new metabolic triad in cyclosporine-treated kidney transplant patients.

BACKGROUND Cardiovascular disease is a major cause of morbidity and mortality after renal transplantation. Prednisone (Pred) maintenance therapy is associated with risk factors for atherosclerosis. Therefore, we were interested in quantifying the effects of Pred withdrawal on body weight and waist circumference as well as on metabolic markers of coronary heart disease risk. METHODS Twenty-six cyclosporine-treated renal transplant patients (13 men and 13 women) were evaluated before and after at least 11 months (16 +/- 2.9 months) of Pred withdrawal. A complete fasting lipoprotein-lipid profile as well as anthropometric measurements were obtained from each patient. RESULTS Pred withdrawal was associated with a 6.0% reduction of body weight (-4.34 +/- 5.40 kg; P < 0.05) and with a 7.7% decrease in waist girth (-7.13 +/- 5.75 cm; P < 0.005) in women, whereas no change in these variables were observed in men. In both genders, plasma low-density lipoprotein (LDL) cholesterol and triglyceride concentrations were unaffected by Pred withdrawal, whereas plasma high-density lipoprotein (HDL) cholesterol levels decreased by 14.0% in women (-0.22 +/- 0.22 mmol/L; P < 0.005) and 22.0% in men (-0.36 +/- 0.28 mmol/L; P < 0.005). Pred withdrawal was associated with a significant reduction in plasma apolipoprotein B concentrations in both women (-0.28 +/- 0.15 g/L; -24.6%; P < 0.0001) and men (-0.22 +/- 0.19 g/L; -20.5%; P < 0.005). A significant reduction in fasting insulin was observed in both women (-27.8 +/- 27.9 pmol/L; -25.3%; P < 0.005) and men (-25.0 +/- 32.8 pmol/L; -21.4%; P < 0.05), whereas the LDL peak particle size was unaffected by Pred withdrawal. CONCLUSIONS Pred withdrawal modifies several anthropometric and metabolic cardiovascular risk factors in renal transplant patients. Furthermore, female patients may derive further benefits of Pred withdrawal resulting from the concomitant loss of body weight and abdominal fat.
Prognostic Significance of CD30 (Ki-1 /Ber-H2) Expression in Primary Cutaneous Large-Cell Lymphomas of T-Cell Origin A Clinicopathologic and Immunohistochemical Study in 20 Patients primary cutaneous large-cell

The histologic and immunophenotypical features of 20 primary cutaneous large-cell lymphomas of T-cell origin were investigated and correlated with clinical data to obtain prognostically relevant criteria. Histologic evaluation, using the updated Kiel classification, showed that these large-cell lymphomas represent a morphologic spectrum, often mak-ing classification rather arbitrary. It is therefore concluded that the clinical relevance of histologic subtyping is limited for this group of lymphomas. Immunophenotypical studies revealed significant differences between CD30-positive and CD30-nega-tive lymphomas. CD30-positive lymphomas generally presented with localized skin disease, and had afavorableprognosis (9 of I Opatients alive and in complete remission; median survival, 3 7 months). In contrast, CD30-negative lymphomas often presented with or rapidly developed generalized disease; all patients died of lymphoma (median survival, 17 months). These findings suggest that CD30 expression is an important prognostic parameter for this
Myoglobin Clearance during Continuous Veno-Venous Hemofiltration with or without Dialysis

The management of acute myoglobinuric renal failure, the major complication of rhab-domyolysis, continues to be a treatment dilemma for the clinician as limited therapeutic options are available. Previously, we have demonstrated that continuous arteriovenous hemofiltration (CAVH) is an effective technique for removing myoglobin in an animal model. In the present study, swine were administered four grams of equine myoglobin intravenously and underwent the continuous veno-venous hemofiltration (CVVH) procedure for six hours each. Animals were studied in each of the following groups: CVVH at a pump rate 100 ml/minute, CVVH at a pump rate 200 ml/minute and CVVH at a pump rate 100 ml/minute plus dialysis at a dialysate flow rate of one Liter/h. Once the filtering process was initiated there was a rapid and sustained production of ultrafiltrate in all groups. The amount of myoglobin excreted in the ultrafiltrate over the six-hour filtering period was 688, 948 and 570 mg which corresponded to 17, 24 and 14 percent of the administered dose, respectively, for the three treatments. In comparison to previous CAVH experiments, CVVH removed more circulating myoglobin and the addition of the dialysis component did not appear to improve removal. Based on these findings, it appears that the CVVH hemofiltration system is a viable option for the removal of systemic myoglobin.
Angiogenesis in the central nervous system: a role for vascular endothelial growth factor/vascular permeability factor and tenascin-C. Common molecular effectors in cerebral neoplastic and non-neoplastic "angiogenic diseases".

Human pathological conditions of the central nervous system (CNS) associated with angiogenesis (i.e. neovascularization) include neoplastic, as well as infectious, ischemic, and traumatic processes. Upregulation of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) and tenascin-C (TN-C) is spatially and temporally related to neovascularization. Spatially, VEGF/VPF and TN-C are both found at the site of neovascularization, but they are not detected in areas of normal brain or in areas without neovascularization. Temporally, VEGF/VPF and TN-C are found at the peak of angiogenesis and are not detected when angiogenesis had ceased.
Cushing's syndrome associated with a chemodectoma and a carcinoid tumour

We present a case of Cushing's syndrome where 111In‐octreotide scanning provided evidence for the presence of two neuroendocrine tumours. Uptake in the right neck corresponded to a chemodectoma, but there was no change in the clinical condition or fall in ACTH levels following surgical resection. Uptake in the left chest was assumed to relate to a bronchial carcinoid, but a tumour could not initially be localized on magnetic resonance imaging (MRI), spiral CT scanning or on selective venous sampling.
Literature on Jim Crow

Southern black life? along with the influence of white racism on class, gender, and power relationships? is central to much of the recent historical literature. Black experience mirrored? and con tinues to mirror? the caste structure of American society over time and place. Until the 1960s, historians largely ignored blacks, the majority of whom lived in the South. There they had struggled behind "the Veil that hung between us and Opportunity," as W. E. B. Du Bois declared in 1903. During the 1970s, however, social his tory infused a "bottom up" approach in slavery, emancipation, and civil rights studies. By the late 1980s, a number of scholars, some using oral history, expanded the study of "the two worlds within and without the Veil" (1). Schol ars now emphasize "black agency" even as they explore the reality of "white supremacy. " Both themes mark contemporary scholarship, un derscoring the importance of sources and per spectives to historical interpretation.
Human Infection with MERS Coronavirus after Exposure to Infected Camels, Saudi Arabia, 2013

We investigated a case of human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) after exposure to infected camels. Analysis of the whole human-derived virus and 15% of the camel-derived virus sequence yielded nucleotide polymorphism signatures suggestive of cross-species transmission. Camels may act as a direct source of human MERS-CoV infection.
Vitamin D deficiency prevalence and risk factors among pregnant Chinese women

Abstract Objective To evaluate vitamin D deficiency prevalence and risk factors among pregnant Chinese women. Design A descriptive cross-sectional analysis. Setting China National Nutrition and Health Survey (CNNHS) 2010–2013. Subjects A total of 1985 healthy pregnant women participated. Possible predictors of vitamin D deficiency were evaluated via multiple logistic regression analyses. Results The median serum 25-hydroxyvitamin D level was 15·5 (interquartile range 11·9–20·0, range 3·0–51·5) ng/ml, with 74·9 (95 % CI 73·0, 76·7) % of participants being vitamin D deficient (25-hydroxyvitamin D <20 ng/ml). According to the multivariate logistic regression analyses, vitamin D deficiency was positively correlated with Hui ethnicity (P=0·016), lack of vitamin D supplement use (P=0·021) and low ambient UVB level (P<0·001). In the autumn months, vitamin D deficiency was related to Hui ethnicity (P=0·012) and low ambient UVB level (P<0·001). In the winter months, vitamin D deficiency was correlated with younger age (P=0·050), later gestational age (P=0·035), higher pre-pregnancy BMI (P=0·019), low ambient UVB level (P<0·001) and lack of vitamin D supplement use (P=0·007). Conclusions Vitamin D deficiency is prevalent among pregnant Chinese women. Residing in areas with low ambient UVB levels increases the risk of vitamin D deficiency, especially for women experiencing advanced stages of gestation, for younger pregnant women and for women of Hui ethnicity; therefore, vitamin D supplementation and sensible sun exposure should be encouraged, especially in the winter months. Further studies must determine optimal vitamin D intake and sun exposure levels for maintaining sufficient vitamin D levels in pregnant Chinese women.
Nouveau-nés de mères dysthyroïdiennes : impact de la mise en place d'un protocole en maternité. L'expérience amiénoise

Le fœtus presente une immaturite thyroidienne le rendant dependant de la fonction thyroidienne maternelle durant la grossesse. Il existe un risque de dysthyroidie neonatale en cas de dysthyroidie maternelle auto-immune. De nombreux bilans thyroidiens etaient donc realises chez les nouveau-nes des que la mere presentait un antecedent de dysthyroidie. Nous avons inclus entre le 1er janvier 2011 et le 31 aout 2013 tous les nouveau-nes ayant eu un bilan thyroidien en maternite. Durant cette periode, les bilans chez les bebes etaient realises des qu’un antecedent de dysthyroidie etait craint chez la maman, prouve ou non et que la dysthyroidie soit auto-immune ou non. Tous ces bebes etaient revus en consultation. Un protocole a ete instaure en septembre 2013 afin de cibler les bilans a realiser chez les nouveau-nes. Si la dysthyroidie maternelle n’etait pas auto-immune, aucun bilan ne devait etre realise chez le nouveau-ne. Entre le 1er septembre 2013 et le 30 juin 2015, nous avons inclus les meres avec dysthyroidie auto-immune ayant eu un bilan en cours de grossesse, les meres dysthyroidiennes d’etiologie encore inconnue a l’accouchement et les nouveau-nes de ces mamans. Seuls les nouveau-nes avec bilan biologique anormal etaient suivis en endocrinologie. Le protocole a permis de reduire significativement le nombre de nouveau-nes preleves pour bilan thyroidien de 2,6% a 1,5% (p=0,001), permettant egalement une diminution du volume de sang preleve. Le nombre de nouveau-nes suivis diminuait egalement. L’adequation au protocole n’est pas parfaite mais s’ameliore au fil des semestres. Le protocole a donc permis d’ameliorer le confort des nouveau-nes en maternite en reduisant le nombre de prelevements sanguins et en rassurant les parents des nouveau-nes aux bilans thyroidiens normaux qui ne necessitaient pas de suivi.
Global 𝒦-exponential trackers for nonholonomic chained-form systems based on LMI

Global 𝒦-exponential controllers are constructed for the tracking control problem of nonholonomic systems in chained form. Compared to previously published papers, a difference is that the reference targets are allowed to converge to a point exponentially. By using a novel transformation and the cascade-design method, the tracking control problem is converted into a stabilisation problem composed of two simple subsystems. Then the LMI-design approach is developed for the stabilising one of the above two subsystems. Assumptions on the reference signal is much more relaxed than our previous papers. A peculiar character of the presented methodology is that global 𝒦-exponential tracking can be successfully obtained for nonholonomic chained-form systems without the popular condition of persistent excitation or not converging to zero. Simulation results on a unicycle mobile robot and an articulated vehicle are presented to show the validity of the proposed strategy.
Modelos de intervención global en personas con trastorno del espectro autista

Hace 30 anos, el autismo se consideraba un trastorno raro de la infancia y frecuentemente se asociaba a la ausencia de conciencia social, dificultades significativas en el lenguaje y discapacidad intelectual grave [1]. Actualmente, los trastornos del espectro autista (TEA) son reconocidos como un conjunto de trastornos del neurodesarrollo que presentan una amplia variedad de expresiones clinicas y que comparten las siguientes caracteristicas: dificultades en el desarrollo de la interaccion social reciproca, dificultades en el desarrollo del lenguaje y la comunicacion verbal y no verbal, y patrones de interes restringido y presencia de conductas repetitivas y restrictivas. Los TEA representan principalmente los trastornos generalizados del desarrollo (TGD) definidos en el Manual diagnostico y estadistico de los trastornos mentales, cuarta edicion, texto revisado, como trastorno autista, sindrome de Asperger y TGD no especificado. Ademas, las ultimas revisiones sugieren que la proporcion de discapacidad intelectual en esta poblacion se aproxima al 50% [2]. A lo largo de los ultimos 25 anos, debido a los cambios conceptuales y categoriales, asi como al desarrollo de metodos de deteccion y diagnostico y al aumento de prevalencia (1 de cada 150, 1 de cada 110) [3,4], los TEA se han convertido en una de las formas mas comunes dentro de las discapacidades del desarrollo [5]. El sustancial aumento del numero de ninos con TEA ha conllevado el aumento de la demanda de servicios de atencion; asimismo, ha favorecido que se planteen cuestiones tales como los procedimientos de deteccion, diagnostico y tratamiento mas apropiados y eficaces. Con instrumentos validos de diagnostico y procesos de cribado precoces, tenemos una oportunidad magnifica para identificar a los ninos con TEA en el segundo ano de vida [6] y poderles proporcionar una intervencion temprana de alta calidad. Cuanto mas temprano se inicia la intervencion en la vida de estos ninos, mejores resultados se evidencian [7]. Las respuestas a las cuestiones anteriores nos hacen reflexionar sobre que decisiones tomar en cuanto a la practica clinica y educativa para los ninos y adultos con TEA y sus familias [8]. Por ello, los modelos de Modelos de intervencion global en personas con trastorno del espectro autista
A patient with HIV-1 superinfection.

An HIV-1–infected patient had a rebound in viremia when antiviral therapy was discontinued as part of a vaccine research protocol. Careful studies showed that this patient was infected initially with subtype AE of the virus but then became infected with subtype B. There was no evidence of dual infection, so the data indicate that this is a case of superinfection with a different strain of HIV-1. Natural infection does not necessarily produce cross-clade protection, a finding that may have implications for the development of a vaccine against HIV-1.
Price Dynamics in a Vertical Sector: The Case of Butter

We develop a reduced-form model of price transmission in a vertical sector, allowing for refined asymetric, contemporaneous and lagged, own and cross price effects. The model is used to analyze wholesale-retail price dynamics in the US butter market. The analysis provides strong evidence of asymmetric price transmissions. It documents the complex nature of nonlinear price dynamics in a vertical sector and its implications for the distribution of future prices. It finds evidence that the asymmetric response to shocks is stronger in the sort run for retail prices, and in the longer run for wholesale prices.
Porous alumina with shaped pore geometries and complex pore architectures fabricated by cyclic anodization.

The fabrication of three-dimensional (3D) architectures withnanoscale dimensions is still an evolving research area ofnanotechnology. Various methodologies including conven-tional and unconventional fabrications, such as photolitho-graphy, scanning beam lithography, molding, embossing, andimprinting, have been developed in the past decade.
Molecular mechanisms of altered cholesterol metabolism in rats with spontaneous focal glomerulosclerosis.

BACKGROUND Imai rats exhibit spontaneous focal glomerulosclerosis (FGS), which is marked by heavy proteinuria, severe hyperlipidemia, and progressive renal insufficiency beginning at 8 to 10 weeks of age. In an earlier study, we reported severe skeletal muscle and adipose tissue lipoprotein lipase, and very low-density lipoprotein (VLDL) receptor deficiencies, which account for elevated plasma VLDL and triglycerides in Imai rats at 34 weeks of age. In this study, we investigated key factors involved in cholesterol metabolism. METHODS Male Imai and Sprague-Dawley control rats were fed a regular rat chow and observed from age 8 through 34 weeks. Hepatic 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase, cholesterol 7alpha-hydroxylase, low-density lipoprotein (LDL) receptor and acyl Co A:cholesterol acyltransferase (ACAT) were measured by Western blot and plasma lecithin:cholesterol acyltransferase (LCAT) protein was measured by enzyme-linked immunosorbent assay (ELISA). RESULTS At 34 weeks of age, the Imai rats showed severe proteinuria, hypoalbuminemia, 60% reduction in glomerular filtration rate (GFR), elevated plasma total and LDL cholesterol and LDL/high-density lipoprotein (HDL) ratio. Imai rats showed a twofold elevation of hepatic HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis, but no significant change in cholesterol 7alpha-hydroxylase, the rate-limiting enzyme in cholesterol catabolism to bile acids. This was accompanied by and largely due to a threefold down-regulation of hepatic LDL receptor, which limits hepatic uptake of LDL; and a threefold up-regulation of hepatic ACAT (P < 0.01), which augments esterification of hepatocyte free cholesterol, thus, limiting cholesterol-mediated feedback regulation of cholesterol synthesis and catabolism. Moreover, plasma LCAT concentration was severely depressed (by fourfold) in Imai rats. This abnormality can impair HDL-mediated cholesterol transport from extrahepatic tissues to the liver. CONCLUSION The study revealed marked abnormalities of the key proteins involved in regulation of hepatic cholesterol metabolism. These abnormalities can account for severe dysregulation of cholesterol metabolism in Imai rats with spontaneous FGS, which closely resembles FGS in humans.
Management of Cataracts in Patients With Glaucoma

The management of the glaucoma patient who has visually significant cataracts is a practical but complex topic. As glaucoma is a chronic, potentially progressive disease that can lead to irreversible blindness, ophthalmologists should develop a treatment approach with emphasis based on the severity of glaucoma rather than on cataract alone. Trabeculectomy remains an effective surgical choice, especially in glaucoma patients with advanced disease who require a low and steady IOP. In planning for cataract surgery, surgeons should be mindful of the alterations of astigmatism in terms of power and axis, axial length fluctuation as a result of trabeculectomy, and the relative position of the IOL after surgery. As glaucoma is a potentially progressive disease, surgeons who treat patients with coexistent glaucoma and cataracts must consider that future glaucoma surgery may be necessary when planning for the cataract surgery. A complete discussion of alternatives would go beyond the limited scope of this study. Regardless of the procedures used, the surgeon should consider the secondary effects of both glaucoma surgery and cataract surgery and their impact on each other when developing an individualized treatment plan.
SUPERCONDUCTIVITY IN DOMAINS WITH CORNERS

We study the two-dimensional Ginzburg-Landau functional in a domain with corners for exterior magnetic field strengths near the critical field where the transition from the superconducting to the normal state occurs. We discuss and clarify the definition of this field and obtain a complete asymptotic expansion for it in the large $\kappa$ regime. Furthermore, we discuss nucleation of superconductivity at the boundary.
Proteinuria: a new marker of long-term graft and patient survival in kidney transplantation.

BACKGROUND Proteinuria developing after renal transplantation is associated with increased renal failure. Moreover, proteinuria in the general population has been shown to be associated with morbidity and mortality due to cardiovascular disease, which is the main cause of death in renal transplant patients. The purpose of the present study was to investigate whether persistent proteinuria following renal transplantation was associated with a worse patient and graft survival. METHODS We analysed kidney recipients included in the Spanish Chronic Allograft Nephropathy Study (n = 3365). Proteinuria at 1 year post-transplantation was analysed as a categorical variable (< 0.5, 0.5-1, > 1 g/day). RESULTS Post-transplant proteinuria at 1 year was detected in 15.3% of patients. Graft survival in proteinuric patients was significantly lower as compared with patients without proteinuria and the survival was worse with increasing amounts of proteinuria. In the groups with proteinuria, renal graft function at the time of the analysis was worse than in the group without proteinuria. Patient survival was lower in patients with proteinuria although there was no difference between the two groups of proteinuric patients. The main cause of death was vascular disease in all groups of patients but especially in proteinuric patients. The relative risk of graft failure and patient death was higher in proteinuric patients: graft failure [0.5-1 g/day: 2.33 (1.79-3.01, P<0.0001); > 1 g/day: 3.46 (2.73-4.39, P<0.0001)], patient death [0.5-1 g/day: 2.05 (1.39-3.01, P = 0.0002); > 1 g/day: 2.3 (1.55-3.39, P<0.0001)]. CONCLUSIONS Proteinuria, as in native kidney disease, is an excellent marker of poor long-term allograft prognosis and is an independent risk factor for total and cardiovascular mortality in the renal transplant population.
2D Spherical Spaces for Face Relighting under Harsh Illumination

In this paper, we propose a robust face relighting technique by using spherical space properties. The proposed method is done for reducing the illumination effects on face recognition. Given a single 2D face image, we relight the face object by extracting the nine spherical harmonic bases and the face spherical illumination coefficients. First, an internal training illumination database is generated by computing face albedo and face normal from 2D images under different lighting conditions. Based on the generated database, we analyze the target face pixels and compare them with the training bootstrap by using pre-generated tiles. In this work, practical real time processing speed and small image size were considered when designing the framework. In contrast to other works, our technique requires no 3D face models for the training process and takes a single 2D image as an input. Experimental results on publicly available databases show that the proposed technique works well under severe lighting conditions with significant improvements on the face recognition rates. Keywords—Face synthesis and recognition, Face illumination recovery, 2D spherical spaces, Vision for graphics.