Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation of TLR 4 / MyD 88 signaling with early miscarriage

To study correlation between TLR4/MyD88 signaling and early miscarriage, thirty women with early miscarriage and thirty women with induced absorption after 6to 10-week pregnancy were enrolled. Chorion and decidual tissues were collected from all patients. TLR4 and MyD88 were detected with immunohistochemical staining and then quantified. Certain cytokines were quantified. HE staining showed that in the presence of early pregnancy loss, trophoblast layer was thinner, cells became flattened, denatured or necrotic and highly acidophilic and fibrosis of connective tissue in villi axis was enhanced in chorion; while in decidua, connections among decidual cells became looser, a part of cells were disassembled or enucleated and cells were highly acidophilic. Serum IL-8 and TNF-α were significantly higher (P < 0.01) while IL-6 is significantly lower (P < 0.01) in early miscarriage patients. Before treatment, serum IL-8 and TNF-α were significantly higher while IL-6 is significantly lower (P < 0.01) in tocolysis patients than those in control group. There was no significant difference among successful and failed tocolysis patients (P > 0.05). Serum IL-8 and TNF-α in successful tocolysis patients were lower while IL-6 was higher after than those before treatment (P < 0.01) and not significantly different from those in control patients (P > 0.05). TLR4 and MyD88 in both chorion and decidual tissue are correlated with occurrence of early miscarriage.
A Novel Replica Allocation Approach Depth-First Iterative-Deepening for Handling Selfishness in

2 Abstract:: In mobile unexpected networks (MANET), nodes move freely and therefore the distribution of access requests changes dynamically. Duplicate allocation in such a dynamic atmosphere may be a important challenge. The communication price has become an outstanding issue influencing the performance of duplicate allocation within the MANET environment. In reality, however, some nodes might egotistically decide solely to work part, or not in the least, with alternative nodes. These selfish nodes may then scale back the knowledge accessibility within the network. In this paper, the impact of selfish nodes in a very mobile unexpected network from the angle of duplicate allocation is examined. This can be termed as selfish duplicate allocation. Especially, a selfish node detection formula is developed during this research work that considers partial selfishness and novel replica allocation technique to properly deal with selfish replica allocation. Depth-First Iterative-Deepening formula is used during this in this work for higher performance.
Recognition from Data Streams of Human Motion Sensor Using Accelerated PSO Swarm Search Feature Selection Algorithm

Human motion sensing technology gains tremendous popularity nowadays with practical applications such as video surveillance for security, hand signing, and smart-home and gaming.These applications capture humanmotions in real-time fromvideo sensors, the data patterns are nonstationary and ever changing. While the hardware technology of such motion sensing devices as well as their data collection process become relatively mature, the computational challenge lies in the real-time analysis of these live feeds. In this paper we argue that traditional data mining methods run short of accurately analyzing the human activity patterns from the sensor data stream. The shortcoming is due to the algorithmic design which is not adaptive to the dynamic changes in the dynamic gesture motions. The successor of these algorithms which is known as data stream mining is evaluated versus traditional datamining, through a case of gesture recognition overmotion data by usingMicrosoftKinect sensors.Three different subjects were asked to read three comic strips and to tell the stories in front of the sensor. The data stream contains coordinates of articulation points and various positions of the parts of the human body corresponding to the actions that the user performs. In particular, a novel technique of feature selection using swarm search and accelerated PSO is proposed for enabling fast preprocessing for inducing an improved classification model in real-time. Superior result is shown in the experiment that runs on this empirical data stream. The contribution of this paper is on a comparative study between using traditional and data stream mining algorithms and incorporation of the novel improved feature selection technique with a scenario where different gesture patterns are to be recognized from streaming sensor data.
Development and validation of instrument for assessing patients’ knowledge, attitude, and practice (KAP) on uncomplicated malaria management

Objectives: To develop and validate patients’ knowledge, attitudes, and practice instrument for uncomplicated malaria (PKAPIUM). Material and Methods: A draft PKAPIUM scale was developed after the review of relevant literature and malaria treatment guidelines, and six experts validated its content. Monte Carlo simulation principle was followed in arriving at 300 patients populations whose data were used to reduce the items based on “Kaiser’s eigenevalue-greater-than-one rule. ” This was followed by the test of validity and reliability to assess the psychometric properties of the instrument. Results: The items content validity indices (I-CVI) and the scale CVI (S-CVI) using universal agreement (UA) within experts (S-CVI/UA) and average CVI (S-CVI/Ave) approaches were good (0.8–1.00), with absence of items’ floor or ceiling effects. Twenty-one items were retained in the new scale arranged under four factors with average variance extracted (AVE) and square root AVE values of 0.58–0.70 and 0.76–0.84, respectively, suggesting convergent and discriminant validities. The goodness-of-fit results [Chi-square (CMIN/DF) = 3.07, p = 0.00], standardized root mean square residual = 0.070, root mean square error approximation = 0.08 confirmed the hypothesized factor structures of the scale whose internal consistency of Cronbach’s alpha and composite reliability values were 0.74 and 0.82, respectively, and stability of ICC = 0.92 [95% confidence interval : 0.87–0.95, F = 43 (p = 0.51)]. Conclusion: The validity and reliability of the PKAPIUM were in acceptable ranges.
Production of Oyster Mushroom (Pleurotus ostreatus) on Substrate Composed from Wheat Straw, Waste Paper and Cotton Seed Waste

Due to the recent insights of the mushroom nutritional and medicinal advantages, interests in mushroom production and consumption have been increasing. The main aim of this paper is to report the effect of substrates’ composed from different mix ratio of wheat straws, waste paper and cotton seed waste on growth, yield and yield related parameters of oyster (Pleurotus ostreatus) mushroom. The experiment was conducted from December 20017 to March 2018. There were five treatments (T1-T5) with two replications in randomized complete design. The quantitative data were collected and analyzed. The results of this experiments indicated that, the fastest mycelia run was recorded from T4 (19.5 days) for complete colonization and the slowest from T1 (28 days) for complete colonization. Fewer days from colonization to primordial formation was taken for treatment T3 and T4 (2.5 days), while more days taken for T5 (4 days. Larger cap diameter (11.19 cm) was recorded for the mushroom grown on T1. While smaller cap diameter 96.23) was recorded for the mushroom grown on T4, shortest stipe length was recorded from the mushroom on T5 while longest stipe length was recorded for T2, (4.11); highest number of fruits recorded for T3 (41.44) while lowest number of fruits recorded for T5 (22.07). Highest number of aborts recorded for T2 (18.78, while the lowest was recorded for T5 (10.37); Highest number of bunches recorded for T4, (4) while the lowest number of bunches recorded for T5 (1.38). Maximum number of fruits 41.44 (T3), highest biological efficiencies 191.745 (T5), were produced from the different substrate composed from wheat straw, waste paper supplemented with cotton seed waste. Treatments T3 and T4 of this experiment gave maximum total biomass and Biological efficiency so that it could be recommended for pilot or large scale production of oyster mushroom.
Facile Green Fabrication of Gold Nanoparticles using Desmostachya Bipinnata and its Biomedical Application Studies

Gold nanoparticles has many applications in medical field such as drug delivery, bio-imaging, cancer therapy etc. Green fabrication of gold nanoparticles was studied using Desmostachya bipinnata (Halfa grass or Darbha). The aqueous extract of this used as reducing agent, mixed with the Chloroauric acid solution and the mixture was kept under continuous stirring. The color change of the solution into ruby red indicates the formation of gold nanoparticles was observed. The synthesized gold nanoparticles was characterized using UVVisible spectrophotometer, the SPR band formed at 560.0 nm. Further, the synthesised gold nanoparticles were subjected to antioxidant property and anti-bacterial activity.
Four-year Incident Neuropathy and its Risk Factors in Subjects with Type 2 Diabetes.

Objective The study assessed the four-year incidence of diabetic peripheral neuropathy (DPN) and the risk factors that can predict incident neuropathy in a south Indian population with type 2 diabetes. Research Design and Methods 1175 diabetic individuals were identified with known diabetes at baseline. At baseline, individuals underwent assessment of fasting plasma glucose and HbA1c levels, body mass index, waist-hip ratio, blood pressure, blood cholesterol and lipid levels, and ophthalmic evaluation including visual acuity, specular microscopy of the corneal endothelium, cataract grading and diabetic retinopathy assessment. Subjects were re-examined after four years for the assessment of incident neuropathy; 713 individuals were found eligible at follow-up. The presence of neuropathy was assessed at baseline and at follow-up and was defined as a Vibration Perception Threshold of ≥ 20 Volts. Results : The four-year incidence of any neuropathy was 28.4%. Factors predictive of incident diabetic neuropathy were greater age at baseline (OR =1.068), higher body mass index (OR =1.034), presence of diabetic retinopathy (OR =4.879) and lower socioeconomic status (OR =4.841), when adjusted for several potential confounding factors. Conclusion The four-year incidence of diabetic neuropathy in a south Indian population with type 2 diabetes is 28% and can be predicted by ophthalmic and clinical variables. These factors may be utilized in the assessment, monitoring and intervention in individuals with diabetes in an effort to prevent or delay the development of diabetic peripheral neuropathy.
MOBIUS: Towards the Next Generation of Query-Ad Matching in Baidu's Sponsored Search

Baidu runs the largest commercial web search engine in China, serving hundreds of millions of online users every day in response to a great variety of queries. In order to build a high-efficiency sponsored search engine, we used to adopt a three-layer funnel-shaped structure to screen and sort hundreds of ads from billions of ad candidates subject to the requirement of low response latency and the restraints of computing resources. Given a user query, the top matching layer is responsible for providing semantically relevant ad candidates to the next layer, while the ranking layer at the bottom concerns more about business indicators (e.g., CPM, ROI, etc.) of those ads. The clear separation between the matching and ranking objectives results in a lower commercial return. The Mobius project has been established to address this serious issue. It is our first attempt to train the matching layer to consider CPM as an additional optimization objective besides the query-ad relevance, via directly predicting CTR (click-through rate) from billions of query-ad pairs. Specifically, this paper will elaborate on how we adopt active learning to overcome the insufficiency of click history at the matching layer when training our neural click networks offline, and how we use the SOTA ANN search technique for retrieving ads more efficiently (Here "ANN'' stands for approximate nearest neighbor search). We contribute the solutions to Mobius-V1 as the first version of our next generation query-ad matching system.
A Multiplayer Voice-Enabled Game Platform

— As elder people become an increasingly large portion of the general population, mental health problems are becoming more common. Diseases such as dementia are the more common in the elder population, and lead to the gradual deterioration of various mental processes. As there is no cure for dementia, there is a big focus on its early detection, as well as Cognitive Stimulation which aims to delay the loss of cognitive ability. However, there are not yet many technological solutions that allow elders to undergo cognitive stimulation exercises in a group context without supervision. This work aims to develop a multiplayer game to be applied in the context of cognitive stimulation. The game, based on the format of a quiz, serves as a platform for elders to exercise their memory in a more interactive way. The multiplayer component allows players to compete with each other, promoting social interaction which is essential for cognitive stimulation. This project also implements Speech and Language Technologies, such as speech synthesis and recognition, present in the VITHEA platform (Virtual Therapist for Aphasia Treatment) that served as an inspiration for this project. The architecture and design of the game aimed to simulate the experience of participating in a question and answer gameshow, using elements like a virtual agent to act as a gameshow host.
Experimental study of eddy viscosity for breaking waves on sloping bottom and comparisons with empirical and numerical predictions

Focus is on the turbulence for a plunging breaker. Laser Doppler anemometer point measurements were used to determine the velocity matrix of a breaking wave on a sloping bottom. Using the Reynolds stress anisotropy for incompressible fluid, it was found that the ensemble averaged measured velocity predicted eddy viscosity is associated with peaks, which are absent in the broadly accepted empirical predictions. The instantaneous eddy viscosity coefficient was determined according to the Reynolds stresses, modified mean velocity and its gradient components and turbulent kinetic energy. The modified mean velocity and its derivatives improve eddy viscosity predictions during the wave period, which gives evidence that the velocity used corresponds well to a rotational part. In addition to the measurement predictions, empirical formulae were used to estimate the eddy viscosity values during the wave period. Furthermore, a meshless numerical model is proposed to determine artificial viscosity and demonstrate its dependence on eddy viscosity in the case of weakly compressible fluid.
Current Searching Methodology and Retrieval Issues: An Assessment

Abstract : The study examined the current state of searching and the preferred method as indicated by the participants. Their views were analyzed and present in several categories. They are: preferred method of searching; status of searching methodology and its future; search systems' performances and the ability to effectively measure these systems; improvements needed in search systems; future role of catalogers and indexers; and searching in the future.
Macro and Microanatomical Study on the Uropygial Gland of the Mule Duck

The study on the gross and histological aspects of the uropygial gland of Mule duck was conducted on ten adult Mule ducks. The uropygial gland was a yellowish-creamy sebaceous gland located under the skin dorsal to the last caudal vertebra. It composed of two pear-shaped elongated lobes and papilla surrounded by downy feather. It was enclosed in a dense irregular connective capsule containing collagen and reticular fibers but devoid from smooth muscle fibers. Each lobe had secretory tubules and one excretory duct. The secretory tubules were arranged into two zones; the central and the peripheral. The epithelium of the secretory tubules was arranged in three layers; the basal, intermediate and secretory cell layers. The secretion of the uropygial gland was made up of lipids and carbohydrates which contribute to the water-repellent properties of the feather coat and serve as protection against microorganism infection.
Up-regulation of SPARC is associated with tumor progression and epithelial SPARC expression is correlated with poor survival and MMP-2 expression in patients with breast carcinoma

Objective: To investigate the potential involvement of secreted protein acidic and rich in cysteine (SPARC) in the progression of the breast tumor and to determine its association with outcome variables and matrix metalloproteinases (MMPs) expression in patients with breast carcinoma (BC). Methods: SPARC expression was examined in 8 pairs of BC tissues and surrounding normal tissues at mRNA and protein levels by qRT-PCR, RNAscope in situ hybridization (ISH), Western blotting, and immunohistochemistry techniques. Immunohistochemical staining of SPARC was done in 26 normal breasts, 76 ductal carcinoma in situ (DCIS), and 198 BC samples. In addition, immunohistochemical staining was performed for MMP-2 and MMP-9 in BC. Results: SPARC expression at mRNA and protein levels was significantly increased in BC tissues compared to the surrounding normal tissues (P < 0.05 and P < 0.01, respectively). RNAscope ISH and immunohistochemistry of SPARC confirmed an increase in SPARC expression in BC tissues compared with the normal tissues. Epithelial SPARC expression increased continuously from normal breast through DCIS to BC (P < 0.001). In patients with BC, high epithelial SPARC expression was associated with worse disease-free survival and overall survival (P = 0.002 and P = 0.048, respectively) and independently predicted worse disease-free survival (P = 0.002). Epithelial SPARC expression was significantly correlated with MMP-2 expression (P < 0.05). Conclusion: Up-regulation of SPARC contributes to breast tumor progression. SPARC expression may be a useful biomarker for the prognostic prediction in patients with BC. SPARC can control extracellular matrix degradation through up-regulation of MMP-2.
Variation of Serum Prostate-Specific Antigen in Men with Prostate Cancer Managed with Active Surveillance

To describe fluctuations in PSA levels in men managed with AS to determine if a single PSA increase is a consistent measure to trigger intervention. We evaluated data on 541 men on AS from 1995 through 2011. PSA variation was described by studying the Kaplan-Meier probability of patients’ PSA levels reaching 4 or 7 ng/mL, going below those thresholds, and then rising to those thresholds again. We also examined PSA variation by calculating the Kaplan-Meier probability of a PSA change followed by an equal or greater change in the opposite direction. We analyzed data on 541 AS patients with a median of 8 PSA measurements (IQR, 6– 12) on AS for a median of 4 years (IQR, 2–6). The 5-year estimate of the probability of reaching a threshold PSA of 7 ng/mL was 40% (95% CI, 35%–46%) and the 5-year estimate of subsequently falling below this threshold was 90% (95% CI, 82%–95%). The 5 year estimate of a PSA direction change was 95% (95% CI, 93–97%) overall and 56% (95% CI, 51%–61%) for PSA direction changes of ≥1 ng/mL. We observed a high probability of variability in PSA levels for men on AS. Corresponding author: Behfar Ehdaie, MD, MPH, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 353 East 68th Street, New York, NY 10065, ehdaieb@mskcc.org. Contribution: All authors (BE, BYP, DDS, PR, VL, KT, JE, and PTS) have contributed equally to the study design, conduct of the study, data collection and analysis, manuscript draft. Attestation: All authors attest to approving the final manuscript. BE, BYP, and DDS have reviewed the original study data and data analysis and attest to the integrity of the original data and the analysis reported in this manuscript. BE and BYP are the archival authors who are responsible for maintaining the study records. Financial Disclosures: None IRB: The data used in this study were reviewed by the IRB and granted a Waiver of Authorization determined to be exempt from human subject research consent requirement. HHS Public Access Author manuscript BJU Int. Author manuscript; available in PMC 2017 October 01. Published in final edited form as: BJU Int. 2016 October ; 118(4): 535–540. doi:10.1111/bju.13328. A uhor M anscript
Demonstrating the SPIDER Runtime for Reconfigurable Dataflow Graphs Execution onto a DMA-based Manycore Processor

Embedded manycore architectures offer energy-efficient super-computing capabilities but are notoriously difficult to program with traditional parallel programming Application Programming Interfaces (APIs). To address this challenge , dataflow Models of Computation (MoCs) are increasingly used as their high-level of abstraction eases the automation of computation mapping, memory allocation, and communication management. Reconfigurable dataflow is a class of dataflow MoC that fosters a unique trade-off between application dynamicity and predictability. This demonstration presents the first embedded runtime manager enabling the execution of reconfigurable dataflow graphs on a Non-Uniform Memory Access (NUMA) architecture. The proposed runtime dynamically deploys reconfigurable dataflow graphs onto clustered Processing Elements (PEs) through the Networks-on-Chips (NoCs) of the manycore architecture. An open-source implementation on the Kalray MPPA R processor demonstrates the feasibility and the great potential of such a runtime.
Two-Chip Wireless H2S Gas Sensor System Requiring Zero Additional Electronic Components

We describe a wireless hydrogen sulfide (H2S) gas sensor system comprised of two integrated circuits: a chemically-sensitive field effect transistor (CS-FET) sensor and a single-chip micro-mote (SCµM). The sensor IC is a bulk transistor functionalized to respond to H2S. The SCµM IC uses an ARM Cortex M0 to digitize sensor voltage via an ADC and transmit data through a 2.4GHz FSK transmitter based on an ultra-small, crystal-free, free-running ring oscillator. The IC pair has combined volume <4mm3, requires only a power source & antenna and no additional components, and has been demonstrated to acquire signals resulting from H2S gas and wirelessly transmit results at 2.4GHz.
Advanced Abdominal and Thoracic Malignancies . Cytoreduction and Cavity Hyperthermic Chemoperfusion Treatment

Since the end of 90’ there has been an increasing applying of peritoneal cavity chemoHyperthermic Perfusion (HIPEC) to treat peritoneal carcinos is from abdominal solid tumours. Following the pioneering experience of Paul Sugarbaker, more than 200 world-wideCenters now treat selected cases of PC from Ovarian, Gastric, Colon, Pseudomyxoma peritonei tumours and those coming directly from the peritoneal serosa, Mesothelioma. Hipec is a suitable and logical option particularly following complete (absence of residual tumour) or optimal (residual tumour less than 2.5 mm in diameter) cyto reduction and it has the goal of killing those Peritoneal Free Cancer Cells (PFCCs) present at the end of the surgical tumour removal in more than 75% of cases. Results from thousands of pubblications and cytations in literature demonstrates that in presence of limited peritoneal carcinosis [1,2] but even in more selected diffused cases the advantage of the treatment combination, Complete cyto reducion and Hipec, is clear in more than 40% of cases, reaching long term survival and even definitive cure in lots of patients. Complete resection of coexistent hepatic metastases doesn’t impact on successful rates [3].