Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of sleep deprivation on audio-visual reaction time in resident doctors – a measure of task performance

s: Background: Sleep deprivation accounts for impaired perception, difficulties in concentration, vision disturbances and slower reactions. Resident doctors experience acute sleep loss during their 24 hr duty period superimposed on a chronic sleep deprived state. Objective: The purpose of this study was to evaluate the effect of sleep deprivation on auditory reaction time and visual reaction time (task performance) in resident doctors due to extended duty hours. Methodology: The audio-visual reaction time was measured at the start and end of 24 hr duty period in 30 resident doctors. Digital Display Response Time apparatus was used to measure the reaction time. Results: The audio-visual reaction time was increased significantly (p<0.05) at the end of the 24 hr duty period. Conclusion: 24 hrs of sleep deprivation as a result of extended duty hours significantly increases the audio-visual reaction time. This decreases the task performance in resident doctors, increases lapses in concentration and causes cognitive slowing. All of this might become an issue in relation to patient safety.
Molecular Bases of the Membrane Association Mechanism Potentiating Antibiotic Resistance by New Delhi Metallo-β-Lactamase 1

Resistance to last-resort carbapenem antibiotics is an increasing threat to human health, as it critically limits therapeutic options. Metallo-β-lactamases are the largest family of carbapenemases, enzymes that inactivate these drugs. Among MBLs, New Delhi metallo-β-lactamase 1 has experienced the fastest and largest worldwide dissemination. This success has been attributed to the fact that NDM-1 is a lipidated protein anchored to the outer membrane of bacteria, while all other MBLs are soluble periplasmic enzymes. By means of a combined experimental and computational approach, we show that NDM-1 interacts with the surface of bacterial membranes in a stable, defined conformation, in which the active site is not occluded by the bilayer. Although the lipidation is required for a long-lasting interaction, the globular domain of NDM-1 is tuned to interact specifically with the outer bacterial membrane. In contrast, this affinity is not observed for VIM-2, a natively soluble MBL. Finally, we identify key residues involved in the membrane interaction of NDM-1, which constitute potential targets for developing therapeutic strategies able to combat resistance granted by this enzyme.
Influence of Cellular DNA Content on Survival in Ovarian Carcinoma

Flow cytometric analysis of nuclear DNA content was performed on paraffin-embedded tissue from 153 ovarian epithelial carcinomas.The DNA ploidy, DNA index, and S phase fraction were determined without knowing the final outcome of the patients. Fifty-one (38%) of the 134 classifiable histograms were considered to be diploid, 70 (52%) aneuploid, and 13 (10%) multiploid. The DNA index was a better prognostic factor for survival than DNA ploidy; 48% of the patients with a small DNA index (less than 1.3) survived for 5 years after the diagnosis, in contrast to 14% of the patients with a large DNA index (greater than 1.3) (P<.0001). Carcinomas with a small S phase fraction (less than 11%) were associated with favorable survival (P=.0002). In multivariate analysis, the size of the residual tumor at surgery (P<.001), the DNA index (P=.001), and the S phase fraction (P=.05) were the only significant independent prognostic factors. The results indicate that flow cytometric nuclear DNA content analysis provides important additional information for the estimation of survival in ovarian carcinoma
Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation.

The role of insulin-induced receptor autophosphorylation in its internalization was analyzed by comparing 125I-labeled insulin (125I-insulin) internalization in Chinese hamster ovary (CHO) cell lines transfected with normal (CHO.T) or mutated insulin receptors. In four cell lines with a defect of insulin-induced autophosphorylation, 125I-insulin internalization was impaired. By contrast, in CHO.T cells and in two other CHO cell lines with amino acid deletions or insertions that do not perturb autophosphorylation, 125I-insulin internalization was not affected. A morphological analysis showed that the inhibition is linked to the ligand-specific surface redistribution in which the insulin-receptor complexes leave microvilli and concentrate on nonvillous segments of the membrane where endocytosis occurs.
Psychometric Validation of Stress and Compliance Scale for Diabetes (SCSD) in Penang, Malaysia

Purpose : To provide factorial analytical findings, and to construct validation and normative data for Malaysian diabetic patients in Penang. Method : A population-based survey was conducted in Penang, Malaysia during Nov 2012 to March 2013. Cluster random sampling technique was employed for the selection of participants in the community. A total of 1924 diabetic patients of age ≥ 18 years (mean age = 39.51 years) were approached; 992 of them were female and 932 male. LISREL 8.30 program was used for assenting factor analysis. Chi-square (χ 2 )/df (degree of freedom) ratio, GFI (goodness of fit index), AGFI (adjusted goodness of fit index) and root mean square error of approximation (RMSEA) were used to evaluate the fit of the model (two-factor). Results : Barlett’s test of sphericity was 1603.417 (p < 0.001) while Kaiser-Meyer-Olkin measure of sampling adequacy was 0.83. Varimax rotation was conducted with these two identified factors. Factor A integrated items 1, 2, 3, 6, 9 and 10, labeled as ‘Perceived Stress’ while Factor B contained items 4, 5, 7, 8 and labeled as ‘Perceived Compliance’. Item variance showed 45.73 % of accountability with Factor A and 13.43 % with Factor B. Mandatory factor analysis for the two-factor of Malaysian version of PSS yielded: GFIs χ 2 (39) = 127.846, p < 0.001, χ 2 /df= 4.1; GFI = 0.97; AGFI = 0.96; RMSEA = 0.06 and CFI = 0.99. Conclusion : SCSD-10 is a reliable tool for assessing stress and compliance among diabetics living in a society. Keywords : Diabetes mellitus, Malaysia stress scale, Stress and compliance scale for diabetes, Stress, Validation, Factor analysis, Barlett’s test, Kaiser-Meyer-Olkin measure
Analyse symbolique de sourires de personnages virtuels

Resume. Afin de concevoir des personnages virtuels capables d’exprimer differents types de sourire durant une interaction avec un utilisateur, nous avons collecte une base de donnees de sourires de personnage virtuel directement crees par des utilisateurs. Cette base de donnees a ete exploree a travers une analyse symbolique descriptive et supervisee afin d’identifier les caracteristiques morphologiques et dynamiques des sourires d’amusement, de politesse et d’embarras. Une analyse non-supervisee de la base de donnees a permis de mettre en evidence d’autres types de combinaisons de sourires.
Changing Mental Health Care in the Cities of Europe

’The debate is over’ was the somewhat surprising headline in a leading European newspaper on the W.H. O. sponsored conference ’Changing mental health care in the cities of Europe’, which was held from April 10-13 1991 in Amsterdam, the Netherlands. After half a century of debate on the issue of deinstitutionalisation the question is not any more if we should close the large mental hospitals, but what follows the closure and how
Sarcoma fusocelular de conjuntiva ocular, reporte de un caso y revisión de la literatura

Los sarcomas oculares en pacientes sin sindrome de inmunodefi ciencia adquirida son en􀆟 dades extremadamente raras. Existen pocos casos reportados de sarcomas originados en la conjun􀆟 va; sin embargo, recientemente ha habido un aumento signifi ca􀆟 vo en la presentacion de informes de sarcomas oculares y anexiales oculares debido a la epidemia del virus de inmunodefi ciencia humana. Presentamos el caso de un paciente masculino de 63 anos de edad con historia de neoformacion granulomatosa en el ojo izquierdo a nivel de la conjun􀆟 va, cerca del canto externo, de 12 meses de evolucion. Se realiza reseccion no oncologica de la lesion por cirujano o􀅌 almologo en noviembre de 2013, con reporte histopatologico de tumor maligno mesenquimatoso con patron fusocelular con IHQ posi􀆟 va a vimen􀆟 na++++; presenta recidiva del tumor con crecimiento progresivo y presencia de vision borrosa a los nueve meses de la reseccion. Se realiza exenteracion orbitaria del ojo izquierdo, la cual se lleva a cabo sin complicaciones; presento adecuada evolucion postoperatoria. Se envia pieza quirurgica a patologia, reportandose sarcoma fusocelular de bajo grado. Se decide presentar el caso dada su rareza
NETWORK ON CHIP BASED HARDWARE ACCELERATORS FOR COMPUTATIONAL BIOLOGY

by Souradip Sarkar, Ph.D. Washington State University December 2010 Chair: Partha Pratim Pande The focus of this thesis is the design and performance evaluation of Network on Chip (NoC) based multi-core hardware accelerators for computational biology. Sequence analysis and phylogenetic reconstruction are the two problems in this domain wh ch have been addressed here. The basic characteristic of sequence analysis is that t is data intensive in nature whereas the kernel operation in phylogenetic reconstruction i s compute intensive. Due to exponentially growing sequence databases, computing sequence align ment at a large-scale is becoming expensive. An effective approach to speed up this operation is o integrate a very high number of processing elements in a single chip so that the ma ssive scales of fine-grain parallelism inherent in this application can be exploited efficie ntly. Network-on-Chip (NoC) is a very efficient method to achieve such large scale integration. The phylogeneti c r construction application involves solving the breakpoint median problem which reduces to s olving multiple instances of the Traveling Salesman Problem (TSP). Specificall y, we (i) propose optimized NoC architectures for different sequence alignment algorithms t at were originally designed for distributed memory parallel computers, (ii) a custom NoC archi te ture for solving the
New Digital LLRF System for HIT

The Heidelberg Ion Therapy Center HIT is in clinical operation since 2009. The accelerator complex consists of a linear accelerator and a synchrotron to provide carbon ions and protons for clinical use as well as helium and oxygen ions. The analog LLRF system for the linac should be replaced after more than 10 years of continuous operation. In its life-time the LLRF caused no interruption of the clinical operation with a downtime of more than 15 minutes. In order to keep the reliability in the next 10 years at least as high, a new digital LLRF system is planned. Further difficulties for the installation of a new system are due to the clinical full time usage of the accelerator and the short maintenance slots of only two days in series.
Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle

Insulin and contraction increase GLUT4 translocation in skeletal muscle via distinct signaling mechanisms. Akt substrate of 160 kDa (AS160) mediates insulin-stimulated GLUT4 translocation in L6 myotubes, presumably through activation of Akt. Using in vivo, in vitro, and in situ methods, insulin, contraction, and the AMP-activated protein kinase (AMPK) activator AICAR all increased AS160 phosphorylation in mouse skeletal muscle. Insulin-stimulated AS160 phosphorylation was fully blunted by wortmannin in vitro and in Akt2 knockout (KO) mice in vivo. In contrast, contraction-stimulated AS160 phosphorylation was only partially decreased by wortmannin and unaffected in Akt2 KO mice, suggesting additional regulatory mechanisms. To determine if AMPK mediates AS160 signaling, we used AMPK α2-inactive (α2i) transgenic mice. AICAR-stimulated AS160 phosphorylation was fully inhibited, whereas contraction-stimulated AS160 phosphorylation was partially reduced in the AMPK α2i transgenic mice. Combined AMPK α2 and Akt inhibition by wortmannin treatment of AMPK α2 transgenic mice did not fully ablate contraction-stimulated AS160 phosphorylation. Maximal insulin, together with either AICAR or contraction, increased AS160 phosphorylation in an additive manner. In conclusion, AS160 may be a point of convergence linking insulin, contraction, and AICAR signaling. While Akt and AMPK α2 activities are essential for AS160 phosphorylation by insulin and AICAR, respectively, neither kinase is indispensable for the entire effects of contraction on AS160 phosphorylation.
Lossless feedback amplifier design

Lossless feedback can be applied to three types of microwave amplifiers: (1) high gain amplifiers (HGA) Mason 1954 (2) low noise amplifiers (LNA) Vendelin 1975 and (3) high power amplifiers (HPA). The LNA and HPA are duals of each other. This paper gives a tutorial review of all three feedback amplifiers.
Therapeutic Human Papillomavirus ( HPV ) Vaccines

Cervical cancer trends to occur in midlife. Most cases are found in women younger than 50. More than 15% of cases of cervical cancer are found in women over 65 but, these cancers rarely arrise in women who have regular tests for cervical cancer screening before they were 65. The most important etiological factor in cervical cancer and precursor lesions is persistent infection by HPV. Thus, an effective HPV vaccine program will be decreasing mortality and morbidity of diseases mediated HPV. FDA [Food and Dreug Administration of the United States] approved to two profilactic vaccines for prevention of HPV dissemination. These vaccines have no therapeutic efficacy on infections and lesions of HPV. Studies on therapeutic vaccines have been proceeding. Therapeutic vaccines purposes be developed cellular immunity against infected cells by stimulating the patients’ immune responses [1].
Adaptación del modelo LTI de canal PLC a las condiciones de la red eléctrica colombiana

espanolActualmente se considera la red electrica como objeto de estudio con el fin de establecer procesos de comunicacion a alta frecuencia, y por esta razon es importante tener un modelo de canal capaz de estimar su comportamiento en un contexto residencial. Aunque en la literatura es posible encontrar varias clases de modelo de canal PLC, ninguno de los documentos presenta un modelo que se ajuste completamente a las condiciones de la red electrica colombiana. En vista de lo anterior, este articulo presenta una adaptacion del modelo lineal e invariante en el tiempo (LTI), propuesto por el grupo PLC de la Universidad de Malaga (Espana), el cual es considerado en Europa como uno de los modelos mas aceptados y capaz de estimar con gran precision el comportamiento de un canal PLC en entornos residenciales. Ademas, para la propuesta del modelo de simulacion del canal propuesto se usara la herramienta Generador de canal PLC (GC_PLC), desarrollada por el mismo grupo, la cual e adaptada a los parametro electricos existentes en Colombia. Al final del documento se presentan los resultados obtenidos bajo el entorno de simulacion para varias condiciones del canal, lo cual fomentara el desarrollo de nuevos proyectos de investigacion relacionados con el uso de la tecnologia PLC, dado que una de las mayores limitaciones para este tipo de estudios es la falta de una herramienta y un modelo para simular el canal PLC.PALABRAS CLAVES: Comunicaciones por linea de Potencia, Modelo de canal PLC, Modelo Lineal e Invariante en el tiempo, Red Electrica. EnglishThe electrical network is currently considered object of study in order to establish communication processes at high frequency, and for this reason it is important to have a channel model capable of estimating their behavior in a residential context. Although in the literature it is possible to find several classes of PLC channel models, none of the papers presents a model that fully adjust to the conditions of the Colombian electrical network. In view of the foregoing, this article presents an adaptation to the Linear and time invariant (LTI) model proposed by the group PLC of the University of Malaga (Spain), which is considered in Europe as one of the most accepted models, capable of estimating with great approximation the behavior of a channel PLC in residential environments. In addition, for the purposes of model simulation of the proposed canal will be using the tool Generator of Channel PLC (GC_PLC), developed by the same group, which is adapted to the existing electrical parameters in Colombia. At the end of the paper are observed the results obtained under simulation environment for various conditions of channel, which will encourage the development of new research projects, related to the use of PLC technology, since one of the major limitations to this type of study is due to the lack of a tool and a model to simulate a channel PLC.KEYWORDS: Electrical network, PLC channel model, Linear and time invariant model, Power Line Communications.
Analysis of the contactless power transfer system using modelling and analysis of the contactless transformer

In this paper, the electrical characteristics of the contactless transformer is presented using conventional coupled inductor theory. Compared with the conventional transformer, a contactless transformer has large airgap, long primary wire and multi-secondary wire. So contactless transformer has large leakage inductance, small magnetizing inductance and poor coupling coefficient. Therefore, large magnetizing current flows through entire primary system due to small magnetizing inductance and the overall system efficiency will be low. In high power applications, contactless transformer is so bulky and heavy that it should be split by some light and small transformers. So contactless transformer needs several small transformer modules which are connected series or parallel to transfer the primary power to the secondary one. This paper shows analysis and measurement results of the each contactless transformer module and comparison results between series-connection and parallel-connection of the contactless transformer. The results are verified on the simulation based on the theoretical analysis and the 30 kW experimental prototype
Trade Multilateralism in Crisis: Limitations of Current Debates on Reforming the WTO, and Why a Game-Changer is Necessary

The problems confronting trade multilateralism have deep roots; technocratic fixes within the WTO, while important, can play only a small part in resolving them. A fundamental rethinking and renegotiation on the narratives that underpin globalisation is necessary if we are to address the crisis trade multilateralism faces today. This chapter offers some concrete recommendations to facilitate this.
Variability of branching of the a. coeliaca (truncus coeliacomesentericus) in the guinea pig (Cavia aperea f. porcellus).

The authors studied branching of the a. coeliaca (the truncus coeliacomesentericus) in a group of Peruvian short-haired guinea pigs, with special reference to its variability. After the animals had been anaesthetized, their arterial bed was injected with red-dyed latex, fixed and dissected. In all 30 guinea pigs (100%), blood was supplied to the unpaired organs of the abdominal cavity by a truncus coeliacomesentericus arising from the aorta abdominalis at fundus ventriculi level. In 53.3% of the cases, the truncus coeliacomesentericus divided into a truncus gastrolienalis sending out an a. gastrica sinistra and an a. lienalis, and to a truncus hepatomesentericus which split up into an a. hepatica communis and a. mesenterica cranialis. An a. coeliaca (tripus Halleri) was found in only one guinea pig (3.3%), as a branch of the truncus coeliacomesentericus. In the remaining cases, the truncus branched in the most varied ways. The a. gastrica sinistra was most frequently (60%) a branch of the truncus gastrolienalis. In 21 cases (70%) there was a single a. gastrica sinistra and in nine cases (30%) it was doubled. In 29 cases (96.7%) the a. hepatica communis arose from the truncus hepatomesentericus. The classic type of division of the a. hepatica communis to an a. hepatica propria and an a. gastroduodenalis was observed in every case (100%). In 100% of the cases, the a. hepatica propria terminated in a r. dexter and a r. sinister to the liver. An a. cystica, as a direct branch of the a. hepatica propria, was formed in 28 cases (93.3%). In every case (100%) the a. pancreaticoduodenalis cranialis was a branch of the a. gastroduodenalis. An a. gastrica dextra was recorded in only eight cases in the series (26.7%)--in 23.3% as a branch of the a. hepatica propria and in 3.3% as a branch of the a. cystica. Duplication of this artery was found in one case (3.3%). An a. lienalis was found in 28 cases (93.3%), as a direct branch of the truncus gastrolienalis; in two cases (6.7%) it was doubled. An a. gastroepiploica sinistra and a. gastroepiploica dextra were present in 100% of the cases. Inter-organ arterial anastomoses were found in 22 guinea pigs (73.3%)--between the spleen and the stomach (36.7%), between the pancreas and the stomach (10%), between the stomach, spleen and pancreas (10%) and, in the remaining cases, as various combinations of these connections. (ABSTRACT TRUNCATED AT 400 WORDS)
Attention-deficit/hyperactivity disorder: an update on medication adherence and persistence in children, adolescents and adults

Suboptimal adherence to treatment regimens is a major obstacle to treatment efficacy and positive outcomes for patients. While poor adherence is common across a variety of chronic conditions, an area which presents unique challenges to clinicians and researchers is non-adherence among pediatric populations. These challenges are well illustrated by the management of attention-deficit/hyperactivity disorder (ADHD), a pervasive pediatric psychiatric condition. The average rates of non-adherence in children and adults ranged between 15 and 87%. Factors predicting increased adherence/persistence included the use of long-acting formulations, younger age, Caucasian background, family structure and the presence and treatment of comorbidities. Decreased adherence/persistence were predicted by multiple daily dosing, family history of ADHD, experiences of adverse effects, stigma and treatment inefficacy. The broad range of non-adherence rates identified reflects the complexities of adherence research in ADHD, and highlights the need for better standardization of adherence/persistence definitions and measurement approaches.
Notice of RetractionResearch about dynamic inflation object impacting on our country's economy

This paper constructs a dynamic stochastic general equilibrium model to analyze the behavior of the unobserved inflation target implicitly included in China's monetary policy in a New Keynesian framework. The empirical evidence suggests that the model is suitable for research on monetary policy and monetary business cycle. The results also support the assumption that China's monetary policy has a dynamic endogenous inflation target which could stabilize inflation. Furthermore, the target responds positively to the productivity shock and negatively to the consumer's demand shock.