Miracle-dz/UniFAR-FTUs huggingface dataset:
Suivi longitudinal des endoprothèses coronaires par analyse de séquences d'images de tomographie par cohérence optique.

Cette these porte sur la segmentation et la caracterisation des arteres coronaires et des endoprotheses (stent) en imagerie de Tomographie par Coherence Optique (OCT). L’OCT est une imagerie de tres haute resolution qui permet d’apprecier des structures fines comme la couche intimale de la paroi vasculaire et les mailles du stent (struts). L’objectif de cette these est de proposer des outils logiciels autorisant l’analyse automatique d’un examen avec un temps d’execution compatible avec une utilisation peroperatoire. Ces travaux font suite a la these de Dubuisson en OCT, qui avait propose un premier formalisme pour la segmentation de la lumiere et la detection des struts pour les stents metalliques. Nous avons revisite la chaine de traitement pour ces deux problemes et propose une methode preliminaire de detection de stents en polymere bioresorbable. Une modelisation surfacique du stent a permis d’estimer une serie d’indices cliniques a partir des diametres, surfaces et volumes mesures sur chaque coupe ou sur l’ensemble de l’examen. L’apposition du stent par rapport a la paroi est egalement mesuree et visualisee en 3D avec une echelle de couleurs intuitive. La lumiere arterielle est delimitee a l’aide d’un algorithme de recherche de plus court chemin de type Fast Marching. Son originalite est d’exploiter l’image sous la forme helicoidale native de l’acquisition. Pour la detection du stent metallique, les maxima locaux de l’image suivis d’une zone d’ombre ont ete detectes et caracterises par un vecteur d’attributs calcules dans leur voisinage (valeur relative du maximum, pente en niveau de gris, symetrie.). Les pics correspondant a des struts ont ete discrimines du speckle environnant par une etape de regression logistique avec un apprentissage a partir d’une verite terrain construite par un expert. Une probabilite d’appartenance des pics aux struts est construite a partir de la combinaison des attributs obtenue. L’originalite de la methode reside en la fusion des probabilites des elements proches avant d’appliquer un critere de decision lui aussi determine a partir de la verite terrain. La methode a ete evaluee sur une base de donnees de 14 examens complets, a la fois au niveau des pixels et des struts detectes. Nous avons egalement valide de facon exhaustive une methode de recalage non rigide d’images OCT exploitant des amers apparies par un expert sur les examens source et cible. L’objectif de ce recalage est de pouvoir comparer les examens coupe a coupe et les indices calcules aux memes positions a des temps d’acquisition differents. La fiabilite du modele de deformation a ete evaluee sur un corpus de quarante-quatre paires d’examens OCT a partir d’une technique de validation croisee par Leave-One-Out.
Some clinical, biochemical and genetic observations on hemoglobin C.

Recent observations (1, 2) in certain American Negroes, of a previously unrecognized abnormal hemoglobin, now designated as hemoglobin C,2 constitute a significant advance in knowledge of familial anemias. The introduction of filter paper electrophoresis (3, 4) for identification of abnormal hemoglobins (5, 6) has facilitated the study of specimens of hemoglobin from a large number of subjects. With this laboratory procedure, the presence of hemoglobin C alone or in combination with another hemoglobin can readily be detected. This report deals with the clinical and hematological manifestations which have been encountered in patients with hemoglobin C. Of the total of twelve individuals included in the present study, one patient was found to have hemoglobin C alone, and thus represented the homozygous state for the gene for this abnormal hemoglobin. Five patients had the combination of genes for sickle and C hemoglobin and therefore belong to the group of patients with "sickle cell-hemoglobin C disease" (7) first described by Kaplan, Zuelzer, and Neel (1). The findings in six individuals with a mixture of hemoglobin C and normal hemoglobin are summarized in the discussion. The finding of a patient whose hemoglobin was entirely of the "C" variety afforded an opportunity to study some of the physico-chemical characteristics of this abnormal hemoglobin, which are included in the present report.
The Role of Genetics Among Stroke Risk Factors : Discussion of Two Rare Genetic Syndromes Associated with Stroke and Literature Review

Ad dress for Cor res pon den ce/Ya z›fl ma Ad re si: Eda Kılıç Çoban MD, Bakırköy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Clinic of 3rd Neurology, İstanbul, Türkiye Phone: +90 212 409 15 15-18 40 E-mail: eda_coban@yahoo.com Re cei ved/Ge lifl Ta ri hi: 05.03. 2014 Ac cep ted/Ka bul Ta ri hi: 21.10. 2014 Stroke is defined as a focal or global neurologic impairment of sudden onset that lasts more than 24 hours or leads to death. The non-modifiable risk factors of stroke include age, race, and sex, and modifiable risk factors include smoking, hypertension, diabetes, and obesity. Previous studies have shown that these risk factors may be responsible for approximately 50% of patients who present with stroke. However, no risk factors were identified in the remaining half, and genetics may have been responsible for this group. In this manuscript, we present 2 patients with rare genetic syndromes, Marfan’s syndrome and Robinow syndrome, who were referred to our clinic with stroke and had no other identifiable risk factors, and highlight the role of genetic syndromes in stroke etiology.
TRANSLATING SINGULAR THIRD PERSONAL PRONOUNS: OBSERVATIONS FROM THE INDONESIAN AND JAPANESE CLASSROOMS

Pertimbangan status bahasa Inggris sebagai bahasa global membuat bahasa tersebut dihargai di seluruh dunia, serta banyak orang yang inginmempelajarinya sampai pada tingkat kemahiran tertentu. Namun, sama halnya belajar bahasa lain bahwa belajar bahasa Inggris bukan hal yang mudah, seperti yang saya buktikan dari pengalaman mengajar ketika di Indonesia dan Jepang. Berdasarkan pengamatan sebagai bukti anekdot, ada beberapa pertimbangan topik yang sangat spesifik yaitu kata ganti orang ketiga tunggal dan menganalisis tantangan yang muncul pada saat saya mengajar topik tersebut bagi siswa-siswa asing ketika berada di Indonesia dan Jepang With Englishâ€™s status as a global language, learning the language has become increasingly important with language fluency highly valued and prized around the world. However, as is the case with learning any other language, learning English is not an easy task, as can be attested to based on my teaching experiences in Indonesia and Japan. Drawing upon observations as anecdotal evidence, I consider a very specific topic - namely, singular third personal pronouns - and analyze the specific set of unique challenges that my Indonesian and Japanese students face with this part of speech.
Effect on Chest Deformation of Simultaneous Correction of Pectus Excavatum with Scoliosis

Objective This paper is to understand the effect of simultaneous correction of pectus excavatum with scoliosis and to provide some useful information for clinical orthopedic surgery design. Methods The method of a three-dimensional reconstruction has been used to the reconstruction of the chest model of pectus excavatum with scoliosis, and the numerical stimulation has been conducted to the process of minimally invasive correction. Three kinds of correction methods have been considered in the numerical simulation, stretch spine, stretch spine and minimally invasive correction at the same time, and release stretch spine after stretch spine and minimally invasive correction of pectus excavatum at the same time. Results It is found that stretch spine may help to correction of scoliosis but aggravate the sternum collapse, and release stretch spine after stretch spine and minimally invasive correction at the same time could not only be good at scoliosis but also improve the collapse of the sternum, which could help to improve the heartbeat and breath of the patients. Conclusion Among the three kinds of correction methods, release stretch spine after stretch spine and minimally invasive correction at the same time could help to improve both the scoliosis and the collapse of the sternum.
The construction of a new Yanomami round-house

The results of a complete quantitative survey of the plant species used in the construction of a recently built communal Yanomami round-house (yano) are presented, together with descriptions of construction techniques and nomenclature. A total of 52 species were recorded as having been used. The most important species employed were Xylopia sp. (Annonaceae) for rafters and tie beams, Manilkara huberi (Sapotaceae) and Centrolobium paraense (Leguminosae) for posts, Socratea exorrhiza (Palmae) for walls and thatch supports, Geonoma baculifera (Palmae) for thatch, and Heteropsis flexuosa (Araceae) for lashing. The choice of species is discussed in the light of recent changes in the lifestyle of the Yanomami and is compared with records of other indigenous Amazonian architecture. RESUMO. -Sao apresentados os resultados de um levantamento completo das especies vegetais utilizadas na construcao de uma habitacao coletiva Yanomami (yano) recentemente erigida, juntamente com descricoes das tecnicas e nomenclatura dessa construcao. Foi registrado um total de 52 especies, das quais as mais importantes sao: Xylopia sp. (Annonaceae) para vigas e traves de amarracao, Manilkara huberi(Sapotaceae) e Centrolobium paraense (Leguminosae) para postes, Socratea exorrhiza (Palmae) para paredes e esteios do teto de palha, Geonoma baculifera (Palmae) para teto de palha e Heteropsis flexuosa (Araceae) para amarracao, Discute-se a selecao de especies a luz de recente rnudancas no estilo de vida Yanomami, selecao essa que e comparada a descricao da arquitetura de outros povos indfgenas da Amazonia.
Healthcare-Seeking Behavior and Sexual Behavior of Patients With Sexually Transmitted Diseases in Nairobi, Kenya

Background Sexualand health-seeking behaviors are important components of sexually transmitteddisease (STD)control. Goals Togenerate data for improved STD prevention and care, and to assess sexualbehavior and relevant health-seekingbehavior. StudyDesign A questionnaire to elicit social, demographic,healthcare-seeking, and sexual behavior information was administered to 471patients attending the referral clinic for STDs in Nairobi,Kenya. Results Alarge proportion of the patients had sought treatment in public and privatesectors before attending the clinic for STDs. Women waited longer than men toseek medical care. In addition, women more than men engaged in sex whilesymptomatic, mostly with their regular partner. Condoms were used rarelyduring illness. In their self-reports, 68% of the men admitted to havingextramarital affairs, and 30% to paying for sex, yet they blamed their wivesfor theirSTDs. Conclusion Healtheducation messages in Kenya need adaptation to improve health-seeking behaviorand safe sexpractices.
New Drug Developments for Bipolar Mania December

The disorder is frequently unrecognized, misdiagnosed, and not optimally managed. Moreover, no agent has been specifically developed on the basis of an understanding of the pathophysiology of the illness or mechanism of action of effective treatments. The current gold standard treatment for BP is lithium, whose mood-stabilizing effects are believed to occur via distinct cellular signaling pathways/targets, such as glycogen synthase kinase 3 inhibition (considered to regulate cellular apoptosis), and other potential downstream cellular mechanisms. In addition to lithium, valproate, and carbamazepine, several atypical antipsychotics (including asenapine) are FDA-approved for the treatment of acute bipolar mania (Table). While these drugs have certainly provided relief for many individuals with BP, significant issues with tolerability and efficacy remain. For instance, clinicians may find themselves in situations in which better-tolerated agents are less effective, and vice versa. In addition, balancing efficacy with adverse effects that affect adherence, such as sedation and weight gain, underscore the urgent need to develop novel and more effective treatments. Recent clinical findings Findings from a meta-analysis indicate that the following agents were more effective than placebo for mania: aripiprazole, asenapine, carbamazepine, cariprazine, haloperidol, lithium, olanzapine, paliperidone, quetiapine, risperidone, tamoxifen, valproate, and ziprasidone). 4 Limited data suggest large effect sizes for carbamazepine, cariprazine, haloperidol, risperidone, and tamoxifen. Another large meta-analysis evaluated the comparative efficacy of aripiprazole, asenapine, carbamazepine, valproate, gabapentin, haloperidol, lamotrigine, lithium, olanzapine, quetiapine, risperidone, topiramate, and ziprasidone at therapeutic doses for treatment of acute mania.5 The study concluded that antipsychotic drugs were significantly more effective than mood stabilizers; olanzapine, risperidone, and quetiapine were better tolerated than haloperidol. Risperidone, olanzapine, and haloperidol were particularly efficacious. Most of the trials were short (typically 3 weeks),
Flexor tendon repair: a comparative study between a knotless barbed suture repair and a traditional four-strand monofilament suture repair

We compared the tensile strength of a novel knotless barbed suture method with a traditional four-strand Adelaide technique for flexor tendon repairs. Forty fresh porcine flexor tendons were transected and randomly assigned to one of the repair groups before repair. Biomechanical testing demonstrated that the tensile strengths between both tendon groups were very similar. However, less force was required to create a 2 mm gap in the four-strand repair method compared with the knotless barbed technique. There was a significant reduction in the cross-sectional area in the barbed suture group after repair compared with the Adelaide group. This would create better gliding within the pulley system in vivo and could decrease gapping and tendon rupture.
A Neutrosophic Image Retrieval Classifier

In this paper, we propose a two-phase Content-Based Retrieval System for images embedded in the Neutrosophic domain. In this first phase, we extract a set of features to represent the content of each image in the training database. In the second phase, a similarity measurement is used to determine the distance between the image under consideration (query image), and each image in the training database, using their feature vectors constructed in the first phase. Hence, the N most similar images are retrieved.
Assessing maternal attachment: first step toward the prevention of child abuse.

Effective treatment of child abuse must be initiated long before abuse begins by identifying the potential child abuser. The obstetric nurse can initiate this process in the first crucial postpartum days by assessing maternal attachment. Through careful observation and interviewing she can identify families-at-risk, and she can then become instrumental in the development and implementation of an effective system of referral and follow-up care. As a result of her efforts such families can be assisted to cope adequately with the stresses of their parental roles, and in extreme cases, serious tragedy may be averted.
Biomass smoke as a risk factor for chronic obstructive pulmonary disease: effects on innate immunity

Chronic obstructive pulmonary disease (COPD), a major cause of mortality and morbidity worldwide, is considered an archetypical disease of innate immunity, where inhaled particles and gases trigger an inflammatory response, favoring tissue proliferation in small airways and tissue destruction in lung parenchyma, in addition to the recruitment of immune cells to these compartments. Although cigarette smoking is still considered the main risk factor for developing COPD, the trend of proposing biomass smoke (BS) exposure as a principal risk factor is gaining importance, as around 3 billion people worldwide are exposed to this pollutant daily. A considerable amount of evidence has shown the potential of BS as an enhancer of lung inflammation. However, an impairment of some innate immune responses after BS exposure has also been described. Regarding the mechanisms by which biomass smoke alters the innate immune responses, three main classes of cell surface receptors—the TLRs, the scavenger receptors and the transient receptor potential channels—have shown the ability to transduce signals initiated after BS exposure. This article is an updated and comprehensive review of the immunomodulatory effects described after the interaction of BS components with these receptors.
Localization of the membrane-associated thiol oxidase of rat kidney to the basal-lateral plasma membrane.

The localization of the membrane-associated thiol oxidase in rat kidney was investigated. Fractionation of the kidney cortex by differential centrifugation demonstrated that the enzyme is found in the plasma membrane. The crude plasma membrane was fractionated by density-gradient centrifugation on Percoll to obtain purified brush-border and basal-lateral membranes. Gamma-Glutamyltransferase, alkaline phosphatase and aminopeptidase M were assayed as brush-border marker enzymes, and (Na+ + K+)-stimulated ATPase was assayed as a basal-lateral-membrane marker enzyme. Thiol oxidase activity and distribution were determined and compared with those of the marker enzymes. Its specific activity was enriched 18-fold in the basal-lateral membrane fraction relative to its activity in the cortical homogenate, and its distribution paralleled that of (Na+ + K+)-stimulated ATPase. This association indicates that thiol oxidase is localized in the same fraction as (Na+ + K+)-stimulated ATPase, i.e. the basal-lateral region of the plasma membrane of the kidney tubular epithelium.
ESTUDIO DE LA VIRULENCIA DE CEPAS MUTANTES DE CANDIDA ALBICANS EN EL ORGANISMO MODELO GALLERIA MELLONELLA

Candida albicans es responsable de una amplia variedad de infecciones mucosas y sistemicas, con una tasa de mortalidad del 35-60%, representando la cuarta causa de infecciones del torrente sanguineo adquiridas en hospitales de EE. UU. Se comparo la sobrevivencia de larvas de G mellonella, infectadas con las mutantes de C. albicans, con la virulencia reportada para estas cepas en el modelo de raton. Durante este experimento se estudiaron tres cepas de Candida albicans; mnt1-mnt2Δ, mnn4Δ y pmr1Δ. Los datos obtenidos de la cepa con el gen mnn4 eliminado discrepan significativamente con los reportados en el raton y sugieren que la relevancia del manosilfosfato durante la patogenesis de C. albicans es hospedero especifico. De Igual manera, para la delecion del gen mnt1-mnt2Δ los datos de virulencia generados en el modelo vertebrado no correlacionan con los obtenidos en larvas de G. mellonella. Finalmente, los resultados en pmr1Δ demostraron que la glicosilacion normal no se requiere para el crecimiento in vitro, pero es esencial para la virulencia de C. albicans. Consideramos que el modelo de G. mellonella permite el estudio a la respuesta de virulencia bajo un diferente kit de defensas antimicrobianas que permitira una mayor comprension los mecanismos de virulencia de C. albicans.
Local and systemic toxicity of nanoscale debris particles in total hip arthroplasty

Over the past 30 years joint replacement prostheses have been developed and refined to enhance durability and reproducibility. Total hip joint arthroplasty is being performed in an increasing number of younger patients; therefore orthopaedic surgeons seek implants with a longer life span. With regards to the progress of mechanical behaviour of the biomaterials used in an arthroplasty, little is known about the long‐term biological effects of wear debris. Owing to the composition of the prostheses currently in use, systemic exposure to chromium (Cr), cobalt (Co), nickel (Ni) and aluminium (Al) alloys occurs as a result of the formation of metal wear nano‐particles that are released both from metal‐on‐metal and polyethylene‐on‐metal bearings, resulting in a postoperative increase in metal ion levels at different organ sites. These particles circulate both locally and systemically, penetrate cell plasma membranes, bind to cellular proteins and enzymes and modulate cytokine expression. Their physiologic effects are poorly understood and their potential toxicity, hypersensitivity and carcinogenicity remain a cause for concern. In this article we will address the issue of whether these nanoscale degradation products are associated with adverse, clinically significant local or systemic toxicologic sequelae. Copyright © 2012 John Wiley & Sons, Ltd.
Toxoplasmosis and primary central nervous system lymphoma in HIV infection: diagnosis with MR spectroscopy.

PURPOSE To differentiate intracranial lymphoma from Toxoplasma gondii lesions in patients infected with the human immunodeficiency virus, by means of localized spin-echo proton magnetic resonance (MR) spectroscopy. MATERIALS AND METHODS Twenty-seven lesions were studied (18 T gondii lesions, nine lymphoma lesions) at 1.5 T. Spectra were acquired at an echo time of 135 msec from voxels centered on the lesions. Both visual analysis and spectral fitting were used to obtain metabolite ratios for choline (Cho), creatine (Cr), N-acetyl (NA), lactate, and lipids. RESULTS Three spectral categories were seen. One had large lipid peaks with suppression of other metabolites. Another had an elevated Cho/Cr ratio with relatively diminished NA. The third had features of the other two. Examples of each spectrum type were acquired from both T gondii and lymphoma lesions. Neither method of analysis allowed differentiation between lesion types. MR spectroscopy showed an overlap of spectra. CONCLUSION The authors conclude that toxoplasmosis and lymphoma cannot be differentiated with spin-echo proton MR spectroscopy at 135 msec.
[Maxillofacial rehabilitation: success or failure? Why?]

INTRODUCTION Most malocclusions are dysfunctional in origin and multidisciplinary care appears essential to correct as well as to maintain the orthopedic treatments performed. However, some "re-"educational therapies do not always deliver the desired results and the persistence of dysfunctions can thus compromise the stability of long-term results of orthodontic treatments. MATERIAL AND METHOD Through a review of the literature, this article analyzes the former and current theories regarding maxillofacial rehabilitation. RESULTS The two theories explaining failures in maxillofacial rehabilitation still need to be considered today because, so far, there are few data on the subject. DISCUSSION The current evolution in the neurosciences makes it possible to achieve a better understanding and an improved technique regarding this type of reeducation, thus promoting greater adaptability on the part of the therapist.