Miracle-dz/UniFAR-FTUs huggingface dataset:
The Stable Isotope Use in the Exploration of Bioavailability and Metabolism of Magnesium

Magnesium (Mg) is a biologically essential mineral and Mg deficiency is known to lead to severe biochemical and symptomatic disorders. Radioactive isotopes and, more recently, stable isotopes have been used as research tools to determine intestinal Mg absorption in humans and animals under different nutritional and physiological conditions. Mg isotopes are given orally or orally plus intravenously and analysed in faeces and/or in plasma and urine in order to calculate intestinal Mg absorption and possibly endogenous Mg excretion. Mg isotopes have been also used to assess exchangeable pools of Mg under nutritional and physiopathological conditions. Mg isotopes are given intravenously and analysed in plasma and urine to calculate the size and half-life of the various Mg exchangeable pools. Finally, Mg isotopes have been used to study the mechanisms of Mg cellular exchange. To this end, erythrocytes or other types of cells are loaded with Mg isotope or incubated in an isotope-rich medium in order to study the Mg flux and its mechanisms. This paper is a report on the use of stable Mg isotopes and their advantages in these different fields of Mg absorption and metabolism. The studies available have clearly demonstrated that stable isotopes provide a useful research tool for determining intestinal Mg absorption, and represent a precious research tool for the study of Mg metabolism and the assessment of Mg status.
An ExpTime Upper Bound for ALC with Integers (Extended Version)

Concrete domains, especially those that allow to compare features with numeric values, have long been recognized as a very desirable extension of description logics (DLs), and significant efforts have been invested into adding them to usual DLs while keeping the complexity of reasoning in check. For expressive DLs and in the presence of general TBoxes, for standard reasoning tasks like consistency, the most general decidability results are for the so-called ω-admissible domains, which are required to be dense. Supporting non-dense domains for features that range over integers or natural numbers remained largely open, despite often being singled out as a highly desirable extension. The decidability of some extensions of ALC with non-dense domains has been shown, but existing results rely on powerful machinery that does not allow to infer any elementary bounds on the complexity of the problem. In this paper, we study an extension of ALC with a rich integer domain that allows for comparisons (between features, and between features and constants coded in unary), and prove that consistency can be solved using automata-theoretic techniques in single exponential time, and thus has no higher worst-case complexity than standard ALC. Our upper bounds apply to some extensions of DLs with concrete domains known from the literature, support general TBoxes, and allow for comparing values along paths of ordinary (not necessarily functional) roles.
Validation of the RHL30 digital gene expression assay as a prognostic biomarker for relapsed Hodgkin lymphoma

Despite continuing improvements in the management of classical Hodgkin lymphoma (cHL), relapse remains associated with a risk of lymphoma‐related mortality. The biological composition of relapse tumour biopsies shows interpatient variability, which can be leveraged to design prognostic biomarkers. Here, we validated the RHL30 assay, a previously reported gene expression model in an independent cohort of 41 patients with relapsed cHL. Patients classified as high‐risk by the RHL30 assay had inferior failure‐free survival (FFS) after autologous stem cell transplantation (2‐year FFS 41% vs. 92%, P = 0·035). The RHL30 model is a robust biomarker that risk‐stratifies patients considered for autologous stem cell transplantation.
The mechanism of Arhalofenate in alleviating hyperuricemia―Activating PPARγ thereby reducing caspase‐1 activity

Hyperuricemia (HUA) is an important risk factor for renal diseases and contributes to gout. Arhalofenate (Arha) has been proved to have uricosuric activity as an inhibitor of URAT1, organic anion transporter 4 (OAT4) and OAT10. However, the effects of Arha on HUA remain unknown. The objective of this study was to investigate whether Arha could alleviate HUA and uncovered the underlying mechanism in vitro. HK‐2 cells were exposed to uric acid (UA) to simulate HUA in vitro. Then cells were treated with Arha, caspase‐1 inhibitor Belnacasan (Beln), caspase‐11 inhibitor Wedelolactone (Wede) and PPARγ inhibitor Mifobate, respectively. The alteration of cell proliferation, inflammation, pyroptosis and expression of related proteins were detected. Results showed that UA exposure inhibited cell viability and increased IL‐1β and IL‐18 generation in a concentration dependent manner. Meanwhile, UA activated the cleavage of gasdermin D (GSDMD), enhanced the protein expression of URAT1, OAT4, TLR4, caspase‐1, and caspase‐11 and reduced PPARγ expression. While the presence of Arha or Beln enhanced cell viability and inhibited cleavage of GSDMD. Wede slightly increased cell viability but failed to prevent GSDMD cleavage. The expression of related proteins except caspase‐11was also recovered by Arha. Beln and Wede partially rescued related proteins level except PPARγ compared with model group. Besides, the co‐treatment of Mifobate blunted the effects of Arha on cell viability and expression of GSDMD, TLR4, and caspase‐1. In conclusion, Arha inhibited UA transport as well as preventing inflammation and pyroptosis via activating PPARγ thereby blocking caspase‐1 activation of HUA in vitro.
SA-RPL: a scheduling-aware forwarding mechanism in RPL/TSCH-operated networks

Wireless sensor networks have shown to be a promising technology for industrial automation in which continuous monitoring is a critical requirement. Deploying an energy-aware sensor network permits increasing the network lifetime and prolonging the monitoring operation. IEEE 802.15. 4e and RPL have been used as de-facto protocols at the access and network layer in low power and low-rate wireless networks. Specifically, the time slotted channel hopping (TSCH) of 802.15. 4e has been designed to provide a reliable access method in low power and lossy networks. More importantly, the combination of TSCH and RPL facilitates providing load-balancing together with energy-saving in such networks. This paper proposes schedule aware RPL (SA-RPL) which aims at prolonging the network lifetime while improving load balancing. It periodically collects scheduling matrix information form TSCH to compute a new measure for selecting the next hop at the network layer. More precisely, the parent with minimum number of occupied cells is more likely to be chosen as the preferred parent. To evaluate the performance of SA-RPL, we modified a distributed management scheme already developed in NS2 simulator. Simulation results show that SA-RPL, compared with other methods, prolongs the network lifetime up to two times and achieves a more uniform energy consumption distribution without decreasing other performance metrics.
A novel site on the chromosome of Staphylococcus aureus influencing the level of methicillin resistance: genetic mapping

The methicillin resistance determinant (mec) maps on linkage group II of the chromosome of Staphylococcus aureus [1]. It resides on an inserted DNA sequence which is not present in sensitive strains [2], and might be located on a transposable element. Most methicillin-resistant strains show a characteristic expression of heterogeneous levels of methicillin resistance [3]. The methicillin resistance level could be lowered by inserting Tn 551, a transposon coding for erythromycin resistance (Ermr), into a specific site on the chromosome of methicillin resistant strains [4]. A genetic analysis of the insertion sites of two such mec inactivating Tn551 transposons is presented in this paper. Cotransformation and cotransduction showed that both Tn551 were mapping between tyrA and thrA and were not linked to the mec determinant. The expression of the methicillin resistance depends therefore not only upon the presence of a mec determinant, but also upon the activity of a chromosomal marker of unknown functions.
Industry application of marbling genetics: a brief review

Improved marbling performance has been recognised for many years as an important objective for the high value export sector of the Australian beef industry. Over the last decade there have been several developments that have provided breeders with substantially better information on which to base breeding decisions aimed at improved marbling performance. These include the application of real-time ultrasound scanning for intramuscular fat percentage (IMF%); the derivation of genetic parameters involving IMF%; the incorporation of IMF% in multi-trait genetic evaluation; and, the industry adoption of selection index technology to assist in optimal multi-trait selection including marbling performance. It is argued that a major constraint to the genetic improvement in beef palatability traits, including marbling performance, has been the inadequate communication of effective market signals and poor information flow through the beef supply chain. This situation is unlikely to change unless the industry achieves a greater degree of vertical co-ordination and improved linkage across the supply chain from the producer to the consumer. There is a need for the implementation of genuine value based marketing systems that provide an appropriate financial incentive for seedstock and commercial beef producers to adopt breeding and management strategies that emphasise the improvement of beef palatability and marbling. The application of gene marker technology will provide future opportunities, as well as additional challenges, in the quest for achieving improved marbling performance.
Common neural and transcriptional correlates of inhibitory control underlie emotion regulation and memory control

Abstract Inhibitory control is crucial for regulating emotions and may also enable memory control. However, evidence for their shared neurobiological correlates is limited. Here, we report meta-analyses of neuroimaging studies on emotion regulation, or memory control and link neural commonalities to transcriptional commonalities using the Allen Human Brain Atlas (AHBA). Based on 95 functional magnetic resonance imaging studies, we reveal a role of the right inferior parietal lobule embedded in a frontal–parietal–insular network during emotion regulation and memory control, which is similarly recruited during response inhibition. These co-activation patterns also overlap with the networks associated with ‘inhibition’, ‘cognitive control’ and ‘working memory’ when consulting the Neurosynth. Using the AHBA, we demonstrate that emotion regulation- and memory control-related brain activity patterns are associated with transcriptional profiles of a specific set of ‘inhibition-related’ genes. Gene ontology enrichment analysis of these ‘inhibition-related’ genes reveal associations with the neuronal transmission and risk for major psychiatric disorders as well as seizures and alcoholic dependence. In summary, this study identified a neural network and a set of genes associated with inhibitory control across emotion regulation and memory control. These findings facilitate our understanding of the neurobiological correlates of inhibitory control and may contribute to the development of brain stimulation and pharmacological interventions.
Kinship bereavement and psychological well-being of U.S. Chinese older women and men

ABSTRACT This study examined the relationship of kinship bereavement with the psychological well-being of Chinese American older women and men. Data from the Population Study of ChINese Elderly were used. Respondents were asked if their spouse, children/grandchildren, siblings, close relatives, and friends had died. Widowhood was associated with more loneliness for both genders. For women, close relative/friend loss was associated with more stress, and children/grandchildren loss was linked to stronger anxiety. Only coefficients for close relative in the stress model were significantly different between genders. The variation in patterns of kinship bereavement may be attributed to Chinese cultural attitudes toward death.
Marketing des traces : du tracking, des contre-mesures et de leur efficacité

RÉSUMÉ. D'un Web de documents à l'intérêt commercial incertain, porté par des pionniers croyant au partage des connaissances, le Web a par la suite évolué vers une forme collaborative et temps réel rentabilisée par la publicité. Cette dernière a évoluée vers la publicité ciblée incluant la publicité comportementale basée sur la collecte massive de traces d'usage. Ces traces proviennent de différents dispositifs de tracking incluant les adresses IP (IP tracking), les désormais connus cookies ou les empreintes (p. ex. browser fingerprinting et canvas fingerprinting). Si la collecte s'est au départ limitée au poste de travail (essentiellement au travers du navigateur), elle a pu par la suite s'étendre aux smartphones et objets connectés. En a découlé le marketing des traces et l'économie de l'attention auxquels les digital natives ont été précocement confrontés. Diverses contres-mesures ont été progressivement déployées par les utilisateurs (paramétrage, extensions, p. ex. bloqueurs de publicités), par des services d'anonymisation (p. ex. VPN et proxy), par les éditeurs euxmêmes ou par le régulateur (p. ex. RGPD). Ce papier exploratoire propose, d'une part, une présentation de la structuration du secteur de la publicité en ligne suivie par un état de l'art sur les outils de tracking qui y sont déployés, d'autre part, un inventaire et une analyse des contre-mesures déployées ainsi que de leur efficacité. Nous montrons en particulier l’évolution rapide des techniques utilisées et l’hétérogénéité de la couverture offerte par des dispositifs protecteurs a priori équivalents.
Desenvolvimento de cafeeiros (Coffea arabica L.) enxertados submetidos a diferentes níveis de reposição de água

Conduziu-se o presente trabalho com o objetivo de avaliar o desenvolvimento de diferentes cultivares de cafeeiro, enxertadas ou nao, quando submetidas a diferentes niveis de reposicao de agua na fase de implantacao da lavoura, na ausencia de nematoides. O experimento foi conduzido em casa-de-vegetacao no Setor de Cafeicultura do Departamento de Agricultura da Universidade Federal de Lavras, no periodo de marco de 2002 a setembro de 2002. O delineamento estatistico utilizado foi em blocos casualizados, em esquema fatorial 4 x 2 x 5, envolvendo quatro cultivares: Acaia Cerrado MG1474, Icatu Amarelo IAC-3282, IAPAR-59 e Rubi MG-1192, dois tipos de mudas (pe franco e enxertadas) e cinco niveis de reposicao de agua (40%, 60%, 80%, 100% e 120% da evapotranspiracao), com intervalos entre as irrigacoes de dois dias. Foram utilizadas 3 repeticoes com 3 plantas por parcela, perfazendo um total de 40 tratamentos, 120 parcelas e 360 plantas no experimento. As caracteristicas avaliadas foram: diâmetro de caule (mm), altura de plantas (cm), numero de pares de folhas no ramo ortotropico, numero de ramos plagiotropicos, massa seca das raizes (g) e massa seca da parte aerea (g). Concluiu-se que plantas oriundas de mudas, das cultivares estudadas, enxertadas sobre Apoata IAC-2258, desenvolvem-se menos que as oriundas de pe franco na fase de implantacao da lavoura, em solos isentos de nematoides; o desenvolvimento do sistema radicular da Apoata IAC-2258 (porta-enxerto) nao e alterado pelo uso de diferentes enxertos de porte alto ou baixo; quando nao ha limitacao hidrica pronunciada, as plantas oriundas de mudas em pe franco desenvolvem-se mais que as plantas provenientes de mudas enxertadas; porem, em condicoes de deficit pronunciado, ambas tem seu desenvolvimento igualmente prejudicado no periodo de implantacao da lavoura, em solos isentos de nematoides.
Pertinence of Telehealth in a Rush Conversion to Virtual Allergy Practice during the COVID-19 Outbreak.

Telephone consultation is one of the most basic forms of telehealth [1], which is based on a wide range of information and communication technologies, enabling external companies and institutions to reach a multitude of users and paving the way for data collection and management interventions [2,3]. The COVID-19 pandemic has led to an unexpected transition from in-person care to telehealth involving not only primary care, but also medical specialties. In Spain, one of the hardesthit countries in the world for recorded cases of COVID-19, specialist care is provided predominantly by public hospitals via outpatient clinics [4]. We describe our experience facing the challenge of creating a “virtual” allergy department in a tertiary care referral hospital and a peripheral outpatient facility serving a population of 430 021 inhabitants in Tenerife, Spain. This study was approved by the Ethics Committee (CEIC) of Hospital Universitario de Canarias, Tenerife, Spain on February 27, 2020 (reference number ISM-DER-2019-01). Our daily routine electronic consultations—in use from April 2012—are text-based, asynchronous, and storeand-forward bidirectionally between a referring clinician and a specialist, thus enabling prioritization of in-person visits according to the medical information provided [5]. Unexpectedly, changes that would typically require months of planning ahead were condensed to go fully virtual in less than 48 hours from Saturday, March 14, when the mandatory national emergency quarantine was declared in Spain. By expeditiously adopting telehealth, the Servicio Canario de Salud, which is the main local stakeholder, granted access through a virtual private network so that specialist medical staff could optimize the number of patients coming in [6]. The number of clinicians who physically staff the office was reduced dramatically to 1 physician and 2 nurses per day, while the remaining staff provided telehealth from their home. Furthermore, in-person care was limited to essential procedures (ie, drug desensitization, administration of biologics, and venom immunotherapy). A specific in-person protective health care circuit was developed (only 1 patient per waiting room) so that patients could receive care with a reduced risk of exposure. 14. Kalchiem-Dekel O, Yao X, Levine SJ. Meeting the challenge of identifying new treatments for type 2-low neutrophilic asthma. Chest. 2020;157:26‐33. 15. Ilmarinen P, Tuomisto LE, Niemelä O, Danielsson J, Haanpaa J, Kankaanranta T, et al. Comorbidities and elevated IL-6 associate with negative outcome in adult-onset asthma. Eur Respir J. 2016;48:1052‐62.
Fcγ Receptor I–Coupled Signaling in Peripheral Nociceptors Mediates Joint Pain in a Rat Model of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is often accompanied by joint pain and inflammation. Previous studies have demonstrated that functional Fcγ receptor I (FcγRI) is expressed in dorsal root ganglion (DRG) neurons and might contribute to pain in rodent models of antigen‐induced arthritis (AIA). This study was undertaken to elucidate the roles of nociceptive neuronal FcγRI–coupled signaling in the development of joint pain in AIA.
Vertical migration of rays leads to the development of a double-storied phenotype in the cambium of Aesculus turbinata

In the vascular cambium of Aesculus turbinata (Blume) the double-storied structure develops slowly. Initially, the arrangement of primary rays is nonstoried. New secondary rays are initiated during cambial expansion. Rays grow by addition of new initials at both ray margins and then split by the intrusive elongation of adjacent fusiform cells. The repetitive splits give rise to groups of several rays of common descent. Initially, the secondary rays are also nonstoried. Later, they become organized into horizontal tiers. This results from the vertical migration of ray initials in the vascular cambium. Controlled polar additions and eliminations of ray-cell initials at the opposite margins of the ray continue until it reaches the appropriate position within the storey of fusiform initials. We postulate that there are at least two mechanisms for the formation and maintenance of ray tiers in cambium. They are unrelated to cell inclination changes, which as described earlier, are known to sometimes induce a do.
Krasilnikovia gen. nov., a new member of the family Micromonosporaceae and description of Krasilnikovia cinnamonea sp. nov.

A novel actinomycete strain was isolated from sandy soil collected in Bangladesh. The culture formed pseudosporangia on short sporangiophores directly above the surface of the substrate mycelium. The pseudosporangia developed singly or in clusters and each pseudosporangium contained many non-motile oval to reniform spores with a smooth surface. The strain 3-54(41)T contained meso-diaminopimelic acid in the cell wall, predominant menaquinone MK-9(H6), and galactose, mannose, xylose and arabinose in the whole-cell hydrolysate. The diagnostic phospholipid was phosphatidylethanolamine, and branched iso-C16:0 (44.0%), iso-C14:0 (13.0%) and unsaturated C18:1 (ω9c) (12.0%) were detected as the major cellular fatty acids. The acyl type of the peptidoglycan was glycolyl, and mycolic acids were not detected. The G+C content of the DNA was 71 mol%. The chemotaxonomic data indicate that this strain belongs to the family Micromonosporaceae. Phylogenetic analysis based on 16S rDNA sequence data also suggested that the strain 3-54(41)T falls within this family. On the basis of phylogenetic analysis and the characteristic patterns of signature nucleotides as well as the morphological and chemotaxonomic data, our isolate is proposed to be Krasilnikovia gen. nov., and this strain should be classified as the species Krasilnikovia cinnamonea sp. nov. in the family Micromonosporaceae. The type strain is 3-54(41)T (=JCM 13252T = MTCC 8094T).
Combinational Treatment of Doxorubicin With Neoadjuvant Docetaxel for Different Subtypes of Patients With Breast Cancer

Aim: The aim of this study is to characterize the effect of chemotherapy drug doxorubicin with neoadjuvant drug docetaxel for different molecular subtypes. Methods: A total of 83 patients with late-stage breast cancer were chosen to undergo treatment and compared to these patients to the combinational treatment to identify the molecular characteristics that can predict the responses. Results: Total response rate is 81.9% (68/83 patients). Among them, 7 patients show pathological complete response of 8.4%, 12 patients show clinical complete response of 14.5%, 49 patients show partial response of 59%, and 15 patients show stable disease of 18.1%. The comparison among different subtypes of breast cancer, including luminal A, luminal B, basal-like, and ERBB2+ subtypes, did not show statistical significant differences to the treatment of combinational treatment for the complete response rate, including pathological complete response and clinical complete response. Comparing with luminal A and luminal B subtypes, the ERBB2+ and basal-like subtypes have better complete response and response rate rates. The disease-free survival rate and overall survival rate at 29 months after treatment did not show statistical significant differences among different subtypes of patients with breast cancer. Conclusion: The molecular subtypes of breast cancer can predict responses to the combinational treatment of doxorubicin with docetaxel, and ERBB2+ and basal-like subtypes have better response rate and complete response rate. There is correlation of estrogen receptor and KI-67 level changes with response rate as well, where KI-67 high patients are more sensitive to the treatment.