Miracle-dz/UniFAR-FTUs huggingface dataset:
Mycotoxins Contamination of Food in Somalia

A paper was recently published in the American Chemical Society (ACS) Journal of Agricultural and Food Chemistry (JAFC) by scientists from the Queens University, Belfast, Northern Ireland, UK and their collaborators. A total of 140 samples (42 maize, 40 sorghum, and 58 wheat) were collected from a number of markets in Mogadishu, Somalia, and analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) multi-mycotoxin method that could detect 77 toxins. All of the maize samples tested contained eight or more mycotoxins, with aflatoxin B1 (AFB1) and fumonisin B1 (FB1) levels reaching up to 908 and 17 322 μg/kg, respectively, greatly exceeding the European Union (EU) and USA allowed limits and guidance values for these toxins. This write up is intended to bring to the attention of the Somali Government and Somali Community at large the serious nature of the risks presented by the issue of contamination of food and animal feed with toxins, at levels well beyond the limits set by advanced industrialized countries as well as international organizations such the World Health Organization (WHO). This review will:
Mathematical Model for Pneumonia Dynamics among Children

There are major advances which have been made to understand the epidemiology of infectious diseases. However, more than 2 million children in the developing countries still die from pneumonia each year. The eorts to promptly detect, eectively treat and control the spread of pneumonia is possible if its dynamics is understood. In this paper, we develop a mathematical model for pneumonia among children under ve years of age. The model is analyzed using the theory of ordinary dierential equations and dynamical systems. We derive the basic reproduction number, R0, analyze the stability of equilibrium points and bifurcation analysis. The results of the analysis shows that there exist a locally stable disease free equilibrium point, E f when R0 1.The analysis also shows that there is a possibility of a forward bifurcation.
Evaluation of antithrombotic and anti-ischemic effects of Morinda citrifolia in renal autotransplantation in rats.

Bobrek transplantasyonu, son donem bobrek yetmezliginin tedavisi amaciyla, insanlardaki kadar yaygin olmamakla birlikte, kedi ve kopekler icin de kullanilan bir renal replasman tedavisidir. Iskemi/reperfuzyon hasari ise bobrek nakillerinde kacinilmaz olarak karsimiza cikan ve gecikmis gref fonksiyon bozukluguna neden olarak nakledilen organin yasam suresini kisaltan bir etken olarak varligini surdurmektedir. Bu calisma ile tropikal bir meyveden elde edilen Morinda citrifolia meyve suyunun bobrek ototransplantasyonu sonrasi olusan iskemi/reperfuzyon hasari uzerine etkilerini degerlendirmek amaclanmistir. Bu maksatla agirliklari 300-350 g arasinda degisen, 24 adet Spraque-Dawley irki erkek sican, Kontrol, M1 ve M2 olmak uzere 3 gruba ayrildi. Preoperatif olarak, Kontrol grubundaki sicanlara % 0,9 NaCl solusyonu (0,5 ml/gun), M1 grubuna Morinda citrifolia meyve suyu (0,5 ml/gun), M2 grubuna ise yine Morinda citrifolia meyve suyu (1 ml/gun) oral yolla 7 gun boyunca uygulandi. Sicanlar 8. gun anesteziye alinarak, ortotopik unilateral bobrek ototransplantasyonu gerceklestirildi. Sicanlara, 24 saatlik reperfuzyon suresi sonunda otanazi islemi uygulandi ve iskemik bobrekler alinarak histopatolojik incelemeye gonderildi. Kesitler, histopatolojik muayene sonuclarina gore, tubul fircamsi kenar kaybi, mononukleer hucre infiltrasyonu, dejenerasyon, tubul lumenleri icinde hyalin olusumu, tromboz ve tubuler nekroz parametreleri acisindan degerlendirilerek skorlandi. Mononukleer hucre infiltrasyonu acisindan M2 grubu ile M1 ve Kontrol grubu arasindaki fark ise onemli bulundu (P<0,05). Histopatolojik kesitlerin hicbirinde tromboz varligina rastlanmadi. Sonuc olarak sicanlarda, Morinda citrifolia meyve suyunun bobrek ototransplantasyonlari sonrasi olusan, iskemi/reperfuzyon hasari uzerine onemli bir iyilestirici etkisi olmadigi sonucuna varildi
Quadratus Lumborum Block for Back Pain Related to Pancreatic
Cancer – A Report of Two Cases

Pancreatic cancer is often accompanied by severe pain. Patients typically experience upper abdominal and/or thoracolumbar back pain. For those cases failing to respond to standard medical management, as suggested by the World Health Organization, interventions designated at interruption of the sympathetic axis (such as neurolysis of the celiac plexus or splanchnic nerves) have been shown to be efficacious. Other than axial drug delivery, there are few interventional alternatives in patients with pancreatic cancerrelated pain. There is little knowledge regarding the therapeutic effects of treating peripheral somatic soft tissue among oncological patients. Here we report on 2 such patients, whose back pain improved following a quadratus lumborum block. Two patients diagnosed with pancreatic cancer presented with severe back pain. The pain pattern and patients’ physical exams were compatible with myofascial pain arising from the quadratus lumborum muscle, possibly irritated by the abdominal tumor. Advanced pain management, including long- and short-acting opioids and adjuvants, as well as celiac plexus neurolytic block, failed to provide satisfactory pain relief. Given the apparent muscular origin of the pain, a bilateral ultrasound-guided quadratus lumborum block was performed. Four weeks post procedure, the 2 patients reported substantial pain relief supported by reduced consumption of pain medication and improved functional status. No adverse events or complications were observed in either case. In the patients described here, quadratus lumborum block proved to be safe and efficacious in alleviating back pain related to pancreatic cancer. In our opinion, clinicians should be aware of the possible contribution of a myofascial component to pain in pancreatic cancer and in cancer-related pain in general. Key words: Quadratus lumborum block, cancer pain, pancreatic cancer, pain control, myofascial pain syndrome, interventional pain management
High-dose chemotherapy of germ-cell tumors - is it the end of the road?

Cell Tumors) stanowi1 niewiele ponad 1 proc. wszystkich nowotworów z3oœliwych. Jednak w grupie mê¿czyzn pomiêdzy 20. i 35. rokiem ¿ycia s1 one najczêœciej rozpoznawanymi nowotworami z grupy guzów litych [1]. Od chwili wprowadzenia schematu BEP jako standardowego leczenia pierwszego rzutu, rokowanie u pacjentów z t1 chorob1, nawet w zaawansowanym stadium (IIB–IIIB), jest jednym z najlepszych w onkologii [2, 3, 4]. Szacuje siê, ¿e szansê na wyleczenie ma nawet 90 proc. wszystkich chorych, z tego 75–80 proc. z nich uzyskuje trwa31 ca3kowit1 remisjê ju¿ po leczeniu pierwszego rzutu. Jednak nie wszyscy pacjenci maj1 równie dobre rokowanie. W ocenie rokowania i w podejmowaniu decyzji terapeutycznych u chorych z guzami zarodkowymi wa¿n1 rolê odgrywa podzia3 na grupy prognostyczne, opracowany przez IGCCCG (International Germ Cell Cancer Collaborative Group) (tab. 1.). U pacjentów z grupy niskiego ryzyka powszechnie przyjêtym standardem jest obecnie podanie 3 kursów chemioterapii BEP, co pozwala na uzyskanie 95 proc. ca3kowitych remisji. Chorzy, u których stwierdza siê niekorzystne czynniki prognostyczne (grupa œredniego i wysokiego ryzyka) powinni otrzymaæ 4 kursy chemioterapii BEP. Pozwala to jednak na wyleczenie tylko 50–65 proc. tych pacjentów. Dodatkowo, w obu grupach, standardowe leczenie obejmuje resekcjê pozosta3ych po chemioterapii zmian resztkowych (jednak tylko przy normalizacji markerów i oczywiœcie jedynie wtedy, gdy taki zabieg jest wykonalny). W œwietle najnowszych doniesieñ, uzupe3niaj1ce leczenie chirurgiczne w istotny sposób zwiêksza odsetek wyleczeñ [5, 6, 7, 8, 9].
SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression

Background: Chemoresistance is a significant obstacle to the effective treatment of breast cancer (BC), resulting in more aggressive behavior and worse clinical outcome. The molecular mechanisms underlying breast cancer chemoresistance remain unclear. Our microarray analysis had identified the overexpression of a small molecular glycoprotein serglycin (SRGN) in multidrug-resistant BC cells. Here, we aimed to investigate the role of SRGN in chemoresistance of breast cancer and elucidate the underlying mechanisms. Methods: SRNG overexpression was identified using microarray analysis and its clinical relevance was analyzed. To investigate the role of SRGN, we performed various in vitro and in vivo studies, as well as characterization of serum and tissue samples from BC patients. Chemosensitivity measurement, gene expression interference, immunofluorescence staining, mammosphere assay, flow cytometry analysis, luciferase reporter assay, ChIP-qPCR, coimmunoprecipitation, and immunohistochemistry were performed to explore the potential functions and mechanisms of SRGN. Results: We confirmed overexpression of SRGN in chemoresistant BC cells and in serum and tissue samples from BC patients with poor response to chemotherapy. SRGN specifically predicted poor prognosis in BC patients receiving chemotherapy. Mechanistically, SRGN promoted chemoresistance both in vitro and in vivo by cross-talking with the transcriptional coactivator YES-associated protein (YAP) to maintain stemness in BC cells. Ectopic YAP expression restored the effects of SRGN knockdown. Inversely, YAP knockdown rescued the effects of SRGN overexpression. The secreted SRGN triggered ITGA5/FAK/CREB signaling to enhance YAP transcription. Reciprocally, YAP promoted SRGN transcription in a TEAD1-dependent manner to form a feed-forward circuit. Moreover, the YAP/RUNX1 complex promoted HDAC2 transcription to induce chemoresistance and stemness in BC cells. Importantly, the SRGN levels were positively correlated with the YAP and HDAC2 levels in chemoresistant BC tissues. YAP and HDAC2 acted downstream of SRNG and correlated with poor outcomes of BC patients receiving chemotherapy. Conclusions: Our findings clarify the roles and mechanisms of SRGN in mediating chemoresistance in breast cancer and suggest its use a potential biomarker for chemotherapeutic response. We believe that novel therapeutic strategies for breast cancer can be designed by targeting the signaling mediated by the crosstalk between SRGN and YAP.
Applications of Control Charts in Medicine and Epidemiology

We consider two applications of control charts in health care. The first involves the comparison of four methods designed to detect an increase in the incidence rate of a rare health event, such as a congenital malformation. A number of methods have been proposed: among these are the Sets method, two modifications of the Sets method, and the CUSUM method based on the Poisson distribution. Many of the previously published comparisons of these methods used unrealistic assumptions or ignored implicit assumptions which led to misleading conclusions. We consider the situation where data are observed as a sequence of Bernoulli trials and propose the Bernoulli CUSUM chart as a desirable method for the surveillance of rare health events. We compare the steady-state average run length performance of the Sets methods and its modifications to the Bernoulli CUSUM chart under a wide variety of circumstances. Except in a very few instances we find that the Bernoulli CUSUM chart performs better than the Sets method and its modifications for the extensive number of cases considered. The second application area involves monitoring clinical outcomes, which requires accounting for the fact that each patient has a different risk of death prior to undergoing a health care procedure. We propose a risk-adjusted survival time CUSUM chart (RAST CUSUM) for monitoring clinical outcomes where the primary endpoint is a continuous, time-to-event variable that is right censored. Risk adjustment is accomplished using accelerated failure time regression models. We compare the average run length performance of the RAST CUSUM chart to the risk-adjusted Bernoulli CUSUM chart, using data from cardiac surgeries to motivate the details of the comparison. In order to make the comparisons between the two charts as fair as possible, the RAST CUSUM chart is based on the assumption that the survival times follow a log-logistic distribution. The comparisons show that the RAST CUSUM chart is more efficient at detecting deterioration in the quality of a clinical procedure than the risk-adjusted Bernoulli CUSUM chart, especially when the fraction of censored observations is not too high. We also present a RAST CUSUM chart based on the Weibull distribution as an alternative to the log-logistic RAST CUSUM chart. We address details regarding the implementation of a prospective monitoring scheme using the RAST CUSUM chart.
Post–market In vitro Equivalency Evaluation of Paracetamol Tablets in Kedah, Malaysia

Six brands of paracetamol (acetaminophen) 500 mg tablets have been evaluated using specific quality control tests for uniformity of weight, hardness, friability, content, disintegration and dissolution with the aim to assess its bioequivalence. The results obtained have been discussed in details using monographs in United States Pharmacopeia and British Pharmacopoeia. In conclusion, despite some apparent minor differences in tablet hardness and disintegration time profiles, the dissolution characteristics of various paracetamol tablets appears to be similar and not significantly different from various manufacturers.
Interpretable Deep Visual Place Recognition

We propose a framework to interpret deep convolutional models for visual place classification. Given a deep place classification model, our proposed method produces visual explanations and saliency maps that reveal the understanding of images by the model. To evaluate the interpretability, t-SNE algorithm is used for mapping and visualization of these latent visual explanations. Moreover, we use pre-trained semantic segmentation networks to label all objects appearing in the visual explanations for our discriminative models. This work has two main goals. The first one is to investigate the consistency of visual explanations by different models. The second goal is to investigate whether visual explanations are meaningful and interpretable or not in an unsupervised manner. We find that varying the CNN architecture leads to variations in the discriminative visual explanations, but these visual explanations are interpretable.
ENHANCED REMOVAL OF CRUDE OIL IN SOIL BY CO Bacillus subtilis CONTAMINATED SOIL IN KANO STATE, NIGERIA

There is increasing concern over the issues of environmental pollution especially one caused by hydrocarbon. Soil samples were obtained from oil contaminated fields in Kano and screened for crude oil utilizing bacterial populations. The composition of the bacterial isolates recovered from the contaminated soil include Bacillus subtilis 3 (37.5%), Bacillus cerrus 2 (25%), Pseudomonas aeruginosa 2 (25%) and Staphylococcus aureus 1 (12.5%). All the isolates were able to utilized Bonny light crude oil as a source of car varying extent. B. subtilis and P. aeruginosa, with very high ability in utilizing the crude oil, were used as co-culture for this bioremediation studies, and were subjected to 5% of crude oil for 56 days at room temperature. The isolates ability to grow in crude oil within the incubation period with co had the highest microbial counts of 1.05±1.04 x 10 B. subtilis had the least count on the zero day of the experiment with mean value of 6.90±1.15 x 10 cfu/ml. The results of the study indicated the potentials of Co subtilis and P. aeruginosa in treating oil spills contaminated soil.
Psychological Well-being of government and private aided Higher Secondary School Teachers

Teachers have always played vital roles in the reconstruction of the society. This study is intended to gain knowledge about Psychological Well-being of Male and Female teachers working in government and private aided higher Secondary schools. This problem has sociological, psychological and educational significance. For that purpose 180 Teachers were selected from different schools out of which 90 were taken government schools and the remaining 90 were taken from Private school. The Psychological Well-being Scale were administered on the selected sample to know their level of Psychological Well-being. Statistical „t‟-test and correlation was applied to analyze the data. It was found that there is significant difference in the psychological well-being of male and female teachers. It was also found that there is significant difference in the psychological well-being of government and private aided school teachers. Key word: psychological well-being, types of school, gender Psychological well-being is about lives going well. It is the combination of feeling good an d functioning effectively. Sustainable well-being does not require individuals to feel good all the time the experience of painful emotions is a normal part of line, and being able to manage these negative or painful emotions is essential for long-term well-being. Psychological well-being is, however, compromised when negative emotions are extreme or very long lasting and interfere with a person's ability to function in his or her daily life. The concept of feeling not only the positive emotions of happiness and contentment, but also such emotions as interest, engagement, confidence, and affection the concept of functioning effectively involver the development of one's potential having some control over one's life, having a sense of purpose and experiencing positive relationship. Who where health is defined as "a state of complete physical mental and social Research Guru Volume-12, Issue-1(June-2018) (ISSN:2349-266X)
Studying full higher order affinity normalized cut

摘 要: 已有的高阶算法中,构建相似模型时仅使用少量超边构建稀疏相似模型,同时高阶相似模型仅考虑使用 单阶的高阶相似关系. 为解决这两个问题,以规范割算法为基础,采用直推式学习技术,从标准化和非标准化拉氏 矩阵两个角度分别构建全相似高阶模型和全相似多阶相似模型. 根据规范割算法构建直推式学习框架,然后展示 该框架如何在算法中训练全相似关系. 研究结果显示,在所提出的算法中超边之间的全相似关系能以一个简洁的 形式应用. 以此为基础,将多阶全相似关系进行融合,提出融合多阶信息的全相似多阶相似模型. 将构建的全相似 高阶相似模型和全相似多阶相似模型应用到规范割算法框架中,提出全相似高阶规范割算法和全相似多阶规范 割算法. 在两种高阶相似模型中,全相似张量采用稀疏张量逆的形式,并且该逆矩阵可以转换为规范割框架中稀 疏张量特征分解问题. 将所提出的算法应用于运动分割,并与现有的高阶算法进行对比,实验结果显示,所提出的 算法具有一定的优势. 关键词: 全相似高阶模型;全相似多阶模型;直推式学习;规范割;运动分割 中图分类号: TP301.6 文献标志码: A
Ruijin robotic thoracic surgery: robot-assisted Ivor Lewis esophagectomy

We are going to share the experience of robotic surgery for esophageal carcinoma. A 46-year-old patient who has esophageal squamous cell carcinoma underwent robotic-assisted Ivor-Lewis esophagectomy in our center. The patient was discharged on postoperative day 8 without any perioperative complications. The postoperative pathologic stage was pT1N0M0.
A Capacious Scrutiny on Automatic Test Packet Generation

These days networks are not getting any smaller, they are increasing in size and it is becoming tedious job for network administrators to debug the network, since they rely on traditional tools such as ping and traceroute for this job. This paper puts forward an automated and systematic approach to test and debug a network called Automatic Test Packet Generation (ATPG). ATPG produces a model which is not dependent on devices after reading configuration from routers. The model is used to generate minimum number of test packets to cover every link in a network and each rule in network. ATPG is capable of investigating both functional and performance problems. Test packets are sent at regular intervals and separate technique is used to localize faults. The working of few offline tools which automatically generate test packets are also given, but ATPG goes beyond the earlier work in static checking (Checking liveness and fault localization).
Phosphoinositide specific phospholipase Cγ1 inhibition-driven autophagy caused cell death in human lung adenocarcinoma A549 cells in vivo and in vitro

Our previous studies indicated that phosphoinositide specific phospholipase Cγ1 (PLCγ1) was involved in autophagy induction in colon and hepatic carcinoma cells. However, whether and how PLCγ1 regulation in human lung adenocarcinoma is linked to autophagy remains unclear. Here, we assessed the protein expression of PLCγ1 in human lung adenocarcinoma tissue using immunohistochemistry assay and the relationship between PLCG1 and autophagy in The Cancer Genome Atlas Network (TCGA) using Spearman correlation analysis and GSEA software. Furthermore, the interaction between PLCγ1 and autophagy-related signal molecules was investigated in human lung adenocarcinoma A549 cells treated with different inhibitors or transduction with lentivirus-mediated PLCγ1 gene short-hairpin RNA (shRNA) vectors using MTT, clonogenicity, Transwell migration, RT-PCR, Caspase-3, mitochondrial transmembrane potential, and western blotting assays, as well as transmission electron microscope technique. Additionally, the effect of shRNA/PLCγ1 alone or combined with autophagic activator Lithium Chloride (LiCl) on tumor growth and metastasis was measured using immunohistochemistry and assays in A549 xenograft nude mouse model. The results showed that increased PLCγ1 expression occurred frequently in human lung adenocarcinoma tissue with higher grades of T in TNM staging classification. PLCγ1 significantly enriched in autophagic process and regulation, which negatively regulating autophagy was enriched in higher expression of PLCγ1. PLCγ1 inhibition partially reduced cell proliferation and migration of A549 cells, with an increased autophagic flux involving alterations of AMPKα, mTOR, and ERK levels. However, PLCγ1 inhibition-driven autophagy led to cell death without depending on Caspase-3 and RIP1. Additionally, the abrogation of PLCγ1 signaling by shRNA and combination with autophagic activator LiCl could efficaciously suppress tumor growth and metastasis in A549 xenograft nude mice, in combination with a decrease in P62 level. These findings collectively suggest that reduction of cell proliferation and migration by PLCγ1 inhibition could be partially attributed to PLCγ1 inhibition-driven autophagic cell death (ACD). It highlights the potential role of a combination between targeting PLCγ1 and autophagy pathway in anti-tumor therapy, which may be an efficacious new strategy to overcome the autophagy addition of tumor and acquired resistance to current therapy.
The effects of TGF-b1 and IGF-I on the biomechanics and cytoskeleton of single chondrocytes

Objective: Ascertaining how mechanical forces and growth factors mediate normal and pathologic processes in single chondrocytes can aid in developing strategies for the repair and replacement of articular cartilage destroyed by injury or disease. This study examined effects of transforming growth factor-b1 (TGF-b1) and insulin-like growth factor-I (IGF-I) on the biomechanics and cytoskeleton of single zonal chondrocytes.