Miracle-dz/UniFAR-FTUs huggingface dataset:
Somatic p 53 Mutations in Human Breast Carcinomas in an Icelandic Population : A Prognostic Factor 1

Mutations in the p53 gene are among the most common genetic changes in human carcinomas. They have been found in many tumor types includ ing colon, lung, and breast. We have used constant dÃ©naturantgel electrophoresis in order to screen samples from 109 breast carcinomas for mutations in four conserved regions, exons 5, 7, and 8, of the p53 gene. Samples were also analyzed for allelic loss of the p53 gene and of markers more distal on chromosome 17p. Mutations were confirmed by DNA sequencing. Mutations were found in 18 of the 109 samples (16.5%). Loss of heterozygosity at 17p was detected in the majority of informative mutated cases. All cases were also screened for germ line mutations, but none were found. The results obtained were analyzed with respect to clinical parameters and prognosis. There was a significant association between p53 mutation and low content of estrogen receptor protein in the tumors (/' = 0.01). An association with poor prognosis was strongly indi cated by mortality rates that were 37.5% among the patients with p53 mutation and 9.4% for the control group (mean follow up, 32 months). P53 mutation was found to be the strongest negative factor against sur vival in a covariate survival analysis (P = 0.001).
CHAP-E: A Plan Execution Assistant for Pilots

Pilots have benefited from ever-increasing and evolving automation techniques for many decades. This automation has allowed pilots to handle increasingly complex aircraft with greater safety, precision, and reduced workload. Unfortunately, it can also lead to misunderstandings and loss of situational awareness. In the face of malfunctions or unexpected events, pilots sometimes have an unclear picture of the situation and what to do next or must find and follow written procedures that do not take into account all the details of the particular situation. Pilots may also incorrectly assume the mode or state of an automated system and fail to perform certain necessary actions that they assumed the automated system would handle. To help alleviate these issues, we introduce the Cockpit Hierarchical Activity Planning and Execution CHAP-E system. CHAP-E provides pilots with intuitive graphical guidance on what actions need to be performed and when they need to be performed based on the aircraft and automation state, and projection of this state into the future. This assists pilots in both nominal and off-nominal flight situations.
Analysis of Vibration in Permanent Magnet Synchronous Machines due to Variable Speed Drives

This paper introduces an analytical approach to investigate the stator vibration in permanent magnet synchronous motor due to variable-speed drives. The origin of vibration is studied first. Using an electromechanical impulse response, a direct link between the electrical input to the stator windings and acceleration of the stator is established. This model allows for efficient and accurate computation of the stator vibration in permanent magnet synchronous machines. Simulations and experiments are conducted to validate the claims.
A note of fingerspelling recognition by hand shape using higher-order local auto-correlation features

The fingerspelling recognition by hand shape is an important step for developing a human-computer interaction system. A method of fingerspelling recognition by hand shape using higher-order local auto-correlation(HLAC) features is proposed. From the experimental results, the proposed method is promising. And to reduce image resolution and to thresholding an image are shown to be effective. In this paper, in order to further improve the fingerspelling recognition performance, we have proposed the use of division of an image in extracting HLAC features. The results show that the division of an image is effective for fingerspelling recognition by hand shape.
Classification of Skin Cancers using Radial basis Function Network

This paper suggests a model for classifying skin lesions into benign and malignant melanoma using radial basis function network (RBFN). The model initially converts the color image into gray image and then applies Median filter for removing thin hairs and other noises. It then segments the cancerous region through segmentation and then extracts features that represent the characteristics of the skin lesion. The RBFN then processes the computed features and classifies the skin lesion either as a benign or a malignant. The paper discusses with intermediate results on sample skin images and exhibits the elegant performance of the suggested model.
A Real-time Hand Gesture Recognition System

Hand gesture recognition can be used in many applications such as interactive data analysis or American Sign Language detection. Current systems are either expensive, unable to run in real time, or require the user wear devices such as custom gloves. We propose an inexpensive solution for predicting hand gestures in real time that uses Microsoft’s Kinect camera. Our system involves training a random forest classifier with a color glove, and then predicting at a pixel level a naked hand. Our system predicts all pixels at about 10 fps, and is resilient to environment differences in prediction. We also conduct extensive experiment studying the random forest classifier and reveal some interesting properties.
Mean-Square Stability and Adaptive Learning in Regime-Switching Models * ( Job Market Paper )

This paper analyzes the necessary and sufficient conditions for stability under recurring structural changes. Using a finite state Markov process to model stochastically evolving, state-dependent parameters I find that by employing the conditions unique to mean-square stability, the minimum state variable (MSV) solution, found in non-linear models of this reduced form, is also stable in the learning sense. However, the choice of parameter values limits the robustness of this result. Furthermore, to illustrate this outcome I develop empirical results for a model similar to Cagan’s 1956 work on hyperinflation for Germany and the United States. I find that during the time of active currency market intervention, monetary policy was not mean-square stable for both the U.S. and Germany. JEL Classifications: E5, F4
Application of Chebyshev Polynomials to Calculate Density and Fugacity Using SAFT Equation of State to Predict Asphaltene Precipitation Conditions

Equations of state are the essential tools to model physical and chemical processes in which fluids are involved. The majority of PVT calculations carried out for oil and gas mixtures are based on a cubic equation of state (EoS). This type of equations dates back more than a century to the famous Van der Waals equation (Van der Waals, 1873). The cubic equations of state most commonly used in the petroleum industry today are very similar to the Van der Waals equation, but it took almost a century for the petroleum industry to accept this type of equation as a valuable engineering tool. The Redlich and Kwong EoS (Redlich & Kwong, 1949) was modified from the VdW with a different attractive term, the repulsive term being the same. Since 1949 when Redlich and Kwong (RK) formulated their two-parameter cubic EoS, many investigators have introduced various modifications to improve ability of RKEoS. Two other well-known cubic equations are Soave-Redlich-Kwong (SRK), (Soave, 1972) and Peng-Robinson (PR) (Peng & Robinson, 1976) equations which have different formulation of the attractive term and are popular in the oil industry in the thermodynamic modeling of hydrocarbon fluids.
Electromagnetic non-destructive evaluation of fiberglass/aluminum laminates using HTS SQUID magnetometers

The aerospace and aeronautical industries pay much attention to improve flight safety of the airlines. In aircraft design it is important to couple low structural weight with high damage tolerance. For this reason, a new class of advanced composite materials, named Fiber/Metal Laminates (FML), which combine the best features of organic matrix composites and metals, are used. In this work, a nondestructive evaluation of FML specimens based on an eddy-current technique that uses an HTS SQUID (Superconductive QUantum Interference Device) magnetometer is proposed. The aim is to demonstrate that this technique is capable of detecting the presence of damage hidden by plastic deformation after impact events.
Identification of GIRK 2-4 subunits in human esophageal smooth muscle cells

Acetylcholine (ACh) secreted from the vagus nerve contributes to the physiological and pathological regulation of the contraction and relaxation of human esophageal smooth muscle. Expression of acetylcholine-sensitive G protein-activated inwardly rectifying potassium channels (GIRKs) occurs widely in the heart, nervous system and gastrointestine, but the role of GIRKs in the esophagus remains unclear. In the present study, expression of the GIRK1-4 subunits in mRNA and total protein was examined in human esophageal smooth muscle cells (SMCs) by reverse transcription polymerase chain reaction (RT-PCR) and Western blotting. mRNA and protein expression of the GIRK2-4 subunits was detected in human esophageal longitudinal muscle (LM) and circular muscle (CM) cells. However, GIRK1 mRNA and protein were not observed in either the esophageal LM or CM. This study is the first to identify the expression of GIRK2-4 subunits in human esophageal SMCs.
A happiness cups system for holding-cup motion recognition and warming-care delivery

In this paper, a Happiness Cups (H-cups) system is proposed to bi-directionally convey the holding-cup motions of paired cups between two remote users. To reach such a goal, a H-cups system is functional through three important components. Firstly, a paired cups embedded with an accelerometer sensor, which is used to transmit the 3-Dimensional acceleration signals to a motion recognizer App designed on an Android phone, and receive the remote recognized motion to blink the specific color on local cup's RGB-LED by Bluetooth. Secondly, an App dealt with the holding-cup motion recognition from cup, which is based on DTW and SVM classifiers, and send the local recognized motion through a midway server then transmit to the remote paired cup by internet. Finally, a midway server is established and used to exchange and forward the recognized holding-cup motion between two paired cups, in which five holding-cup motions, including, drinking, horizontal shaking, vertical shaking, swaying and toasting are proposed and recognized by DTW and SVM. The experimental results indicate that the recognition accuracy of user's holding-cup motion are able to reach 88.0% and 92.4% in terms of DTW and SVM, respectively.
Moving Object Detection Using a Stereo Camera Mounted on a Moving Platform

In this paper, we propose a method for detecting moving objects using a moving stereo camera. First, the camera motion parameters are estimated by using optical flow with a stereo camera. Second, the optical flow occurring in the background is removed. Finally, moving objects are detected individually by labeling the remaining optical flow. The proposed method is evaluated through experiments using two pedestrians in an indoor environment.
Animal Manure as Alternatives to Commercial Fertilizers in the Southern High Plains of the United States: How Oklahoma Can Manage Animal Waste

The Southern High Plains (SHP) in the United States is one of the leading livestock producing regions in the US (Wright et al., 2010). More than 7 million fed cattle, which accounts for about 30% of the nation’s production, are currently marketed annually in this region (Biermacher et al., 2005). Most recognize the Oklahoma Panhandle as the epicenter of the 1930’s Dust Bowl in the U.S., but over the past two decades swine production in the Oklahoma Panhandle has increased 164 fold as illustrated in Figure 1 (Lowitt, 2006). Today the Panhandle is one of the more important swine producing regions in the U.S (Park et al., 2010). As elsewhere in the U.S., e.g. Iowa and North Carolina, the exponential rise in swine numbers was from the intensification of swine production, i.e. including concentrated animal feeding operations (CAFOs) and other large scale feeding operations (Williams, 2006). The Oklahoma Senate Bill 518 was passed in 1991, which eased restrictions on large concentrated animal feeding operations (Carreira et al., 2006). A similar story has taken place in Eastern Oklahoma, which experienced a similar exponential growth of poultry production in the 1990’s (Fochta, 2002). Approximately 48.2 million birds were produced in Oklahoma during 2007 (NASS, 2007). Over the past two decades, the continuous application of poultry litter, a mixture of bedding material and manure, on some poultry farm’s soils has led to a build-up of phosphorus (M3-P), at times exceeding 150 and 200 mg kg-1 (Penn et al., 2011). Because of current environmental regulations that prevent further P application once thresholds are met, there now exists a need to move the poultry litter off-farm (Van Horn, et al., 1996; Collins and Basden, 2006). The large-scale animal feeding operations in beef cattle, swine, and poultry production have played a major role in the economy of the southern high plains region (Carreira et al., 2007). The introduction of the animal production industries has provided a more profitable alternative to traditional agricultural enterprises in the region, such as wheat and stocker cattle, which have struggled to remain competitive with producers in the more profitable Corn Belt. For instance, the swine industry’s economic importance in the Oklahoma
H∞ control and filtering with sampled measurements

In this paper, H<sub>∞</sub> control and filtering problems for sampled-data systems are studied. Necessary and sufficent conditions are obtained for the existence of controllers and filters that satisfy a specified H<sub>∞</sub> performance bound. And when these conditions hold formulae for controller and filter satisfying the H<sub>∞</sub> bound are alos given.
Technique for rapid, in-line characterization of switching history in partially depleted SOI technologies

Switching history arising from body potential deviations in partially depleted (PD) SOI devices is a key technology performance metric and real-time feedback on switching history trends is important in reducing SOI technology development cycle times. Detailed switching history can be obtained from time resolved gate delay measurements but these are ill-suited to in-line test in terms of lack of automation, required equipment or test time. We have developed a technique and circuit to enable the in-line measurement of average switching history to an accuracy of a few percent - sufficient for process development needs. The circuit requires only "DC" inputs, is self-timed, self-calibrating and tested with conventional in-line parametric testers.
The HVTN : Strategic Accomplishments of the First Decade and Beyond

Tracey Day, Cecilia Morgan, Adi Ferrara, and Jim Kublin Welcome to a new edition of the HVTNews, the newsletter of the HIV Vaccine Trials Network. Our newsletter’s mission is to provide timely updates on the science of HIV vaccines, and the science of the HVTN. To that end, this issue features discussions that include innate immunity studies at the HVTN, the possible impact of the RV144 Correlates Analyses on future vaccine trials, and the Network’s ongoing commitment to its study participants via our VISP testing service. Our featured article in this issue is a look back at the Network’s achievements in 12 years of operation, and the impact it had on the HIV vaccine field.
Ambipolar Black Phosphorus MOSFETs With Record n-Channel Transconductance

Ambipolar black phosphorus MOSFETs with record n-channel extrinsic transconductance are reported. The devices consist of multilayer black phosphorus aligned to a local back-gate electrode with 10-nm-thick HfO<sub>2</sub> gate dielectric. Before passivation, devices with 0.3-μm gate length behaved as p-MOSFETs with peak extrinsic transconductance, g<sub>m</sub>, of 282 μS/μm at V<sub>DS</sub> = -2 V. After passivation, the same devices displayed the ambipolar behavior, and when tested as n-MOSFETs, had peak g<sub>m</sub> = 66 μS/μm at V<sub>DS</sub> = +2 V, and similar devices on the same wafer had g<sub>m</sub> as high as 80 μS/μm. These results are an important step toward the realization of high-performance black phosphorus complementary logic circuits.
Band offsets of atomic-layer-deposited Al2O3 on GaAs and the effects of surface treatment

The metal gate/high-k dielectric/III-V semiconductor band alignment is one of the most technologically important parameters. We report the band offsets of the Al/Al2O3/GaAs structure and the effect of GaAs surface treatment. The energy barrier at the Al2O3 and sulfur-passivated GaAs interface is found to be 3.0±0.1 eV whereas for the unpassivated or NH4OH-treated GaAs is 3.6 eV. At the Al/Al2O3 interface, all samples yield the same barrier height of 2.9±0.2 eV. With a band gap of 6.4±0.05 eV for Al2O3, the band alignments at both Al2O3 interfaces are established.
A Novel Phase Shifter for Ku-Band High-Power Microwave Applications

A novel phase shifter used to adjust the output phase of high-power microwave (HPM) is investigated. It is noticed that the waveguide wavelength and propagation constant of the TE10 mode are functions of the wide side dimension of the rectangular waveguide, and therefore the output phase of the microwave can be adjusted by changing the wide side dimension. In this paper, an HPM waveguide phase shifter with the wide side dimension adjustable is designed and analyzed numerically. No dielectric or metal pins are involved in this phase shifter, and the microwave propagates in the TE10 mode. In addition, it has a high power-handling capacity. Results show that the phase shifter could operate at a frequency of 15.2 GHz, and the phase of the wave can be adjustable in a range of 0 °-360 ° with a transmit efficiency over 96%. The dimensions of the phase shifter are 13.8 mm × 7.9 mm with a phase shifting length of 139 mm. This novel phase shifter is of interest to HPM applications and higher microwave band.
Effects of information structure, syllable structure, and voicing on nuclear falling pitch accents in German

Previous work showed that tonal alignment distinguishes information status (given/new), that syllable structure affects alignment and that the scaling and alignment of tones correlate with focus. We investigate the interaction of these effects on the tonal realization of nuclear falling accents in German. In a production experiment, syllable structure [± open syllable] and voicing of the following consonant [± voice] was systematically varied in four different information structure contexts: broad focus, narrow focus, contrastive focus and givenness. The results show that [± voice] of the following consonant had a significant effect: The F0 peak of the nuclear falling accents is systematically realized in the post-accented syllable if it was followed by a [+voice] consonant while it is realized towards the end of the accented syllable if it was followed by [-voice] consonant. The results further replicate well-established effects of information structure on the tonal alignment and scaling. The reported results will add to a growing body of studies on fine phonetic detail. In addition, results will also have consequences for annotation of German intonation.
Equivalent circuit model for modular high voltage power generation architectures

This paper introduces the unified equivalent circuit model for modular high voltage(HV) power generation architectures. The HV generation architectures are introduced considering the modularity of key HV components such as transformers or rectifier circuits firstly. An equivalent resister and capacitor circuit network is adopted to model the HV transformer and multi-stage voltage multiplier circuit for HV generation architectures to simplifies the analysis, design and optimization for HV generation architectures. The expressions of equivalent resister and capacitor network in modular HV generation architectures are deduced. Based on the proposed equivalent circuit model, a 400kHz switching frequency 500W 20kV output HV generator prototype based on modular HV architecture is built to validate the equivalent circuit model. The experimental results of HV generator prototype are given finally.
Scanning the Immunopathogenesis of Psoriasis

Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been profoundly revised following recent advances in the understanding of its pathophysiology. In the current model, a crosstalk between keratinocytes, neutrophils, mast cells, T cells, and dendritic cells is thought to create inflammatory and pro-proliferative circuits mediated by chemokines and cytokines. Various triggers, including recently identified autoantigens, Toll-like receptor agonists, chemerin, and thymic stromal lymphopoietin may activate the pathogenic cascade resulting in enhanced production of pro-inflammatory and proliferation-inducing mediators such as interleukin (IL)-17, tumor necrosis factor (TNF)-α, IL-23, IL-22, interferon (IFN)-α, and IFN-γ by immune cells. Among these key cytokines lie therapeutic targets for currently approved antipsoriatic therapies. This review aims to provide a comprehensive overview on the immune-mediated mechanisms characterizing the current pathogenic model of psoriasis.
WZ-GaN based Quasi-Read ATT diode: A novel high-power THz device with reduced parasitic resistance

Simulation investigation is carried out on the single drift region and Quasi-Read type hexagonal GaN based IMPATT devices for Terahertz frequency operation. It is observed that Quasi-Read GaN IMPATT may generate a RF power density of ∼43×1010 Wm−2 with an efficiency of 20%, whereas its flat profile counterpart is capable of delivering a power density of 31×1010 Wm−2 with an efficiency of 17%. The total parasitic series resistance, including the effects of ohmic contact resistances, has been found to be a major problem that reduces the RF power output of the THz IMPATTs significantly. The study reveals that the value of RS decreases by 30% as the doping profile of the diode changes from flat to Quasi-Read type with the incorporation of the charge bump. This study establishes the advantages of Quasi-Read type IMPATT over its flat profile counterpart to realize a high-power source in the THz regime.
Calculation of a constant Q spectral transform

The frequencies that have been chosen to make up the scale of Western music are geometrically spaced. Thus the discrete Fourier transform (DFT), although extremely efficient in the fast Fourier transform implementation, yields components which do not map efficiently to musical frequencies. This is because the frequency components calculated with the DFT are separated by a constant frequency difference and with a constant resolution. A calculation similar to a discrete Fourier transform but with a constant ratio of center frequency to resolution has been made; this is a constant Q transform and is equivalent to a 1/24‐oct filter bank. Thus there are two frequency components for each musical note so that two adjacent notes in the musical scale played simultaneously can be resolved anywhere in the musical frequency range. This transform against log (frequency) to obtain a constant pattern in the frequency domain for sounds with harmonic frequency components has been plotted. This is compared to the conventio.