Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor de células granulares de piel mamaria : Estudio morfológico de dos casos mostrando inmunorreactividad frente a-inhibina

Introduction: Granular cell tumors (GCT) are infrequent in the breast, accounting for only a small proportion (6-8%) of all GCT, often manifesting as lesions affecting the mammary skin. Material and methods: 8000 breast biopsy specimens of mammary (with 2200 breast cancer diagnoses), processed over a 19 year period at La Fe University Hospital of Valencia, were reviewed by means of a retrospective morphological study (optical, immunohistochemical and ultrastructural examination) based on the original paraffin-embedded material for possible GCT. Results: Two cases of GCT with mammary skin involvement were found, with two different clinical presentations (CGT as a single tumor nodule and CGT as multiple tumoral lesions associated with a mastectomy scar). In addition to other already well known characteristics (cytoplasmic granules PAS + diastase resistant, positivity for S-100, VT and CD68, and numerous lysosomal dense bodies at ultrastructural level) both cases showed immunohistochemical reactivity against (a-inhibin. Conclusions: GCT affecting mammary skin shows immunoreactivity against a-inhibin, a feature which extends the applicability of this antibody on adding it to the existing immune marker panel for diagnosis of CGT.
Hip involvement and its predicting factors in Turkish ankylosing spondylitis: a single center experience

Yard. Doç. Dr. Dilek Solmaz. Nam›k Kemal Üniversitesi Sa¤l›k ve Uygulama Araflt›rma Hastanesi, ‹ç Hastal›klar› Anabilim Dal›, Romatoloji Bilim Dal›, Tekirda¤. e-posta: d.solmaz2012@gmail.com Ç›kar çak›flmas› / Conflicts of interest: Ç›kar çak›flmas› bulunmad›¤› belirtilmifltir. / No conflicts declared. www.raeddergisi. org doi:10.2399/raed.15. 20592 Karekod / QR code: Ankilozan spondilitte kalça tutulumu ve iliflkili faktörler: Tek merkez deneyimi
Bismuth Oxide Nanoparticles Induced Oxidative Stress-Related Inflammation in SH-SY5Y Cell Line

DOI : 10.26650/IstanbulJPharm.2019. 19020 Bismuth (III) oxide nanoparticles’ (Bi2O3-NPs) unique physicochemical properties attracted the attention in biological, industrial, technological and medical fields. Concurrently, increasing numbers of studies revealing their potential toxic effects and possible toxicity mechanisms are ongoing. In this study, we assessed the toxic potentials of Bi2O3-NPs in human SH-SY5Y neuroblastoma cell line. After Bi2O3-NPs characterization using TEM, the cytotoxic potentials were evaluated by MTT and LDH assays. The induction of reactive oxygen species production was evaluated by H2DCFDA. In order to evaluate the oxidative damages, the changes in antioxidant catalase and superoxide dismutase and glutathione levels were determined. The cellular death pathway and the role of immune response were studied by measuring the mRNA expression levels of related genes. Our results showed that Bi2O3-NPs decreased the cell viability through disruption on mitochondrial activity (IC50:77.57 μg/mL) and membrane integrity (LDH%50:16.97 μg/mL). At 50 μg/mL Bi2O3-NPs, the production of reactive oxygen species (ROS) was induced significantly as well as the catalase and superoxide dismutase levels. In immune response, the mRNA expression levels of interleukin (IL)-6 were increased more than 1.5-fold in all doses; whereas, TNF-α, NF-ĸB and MAPK8 expressions were remained unchanged. Consequently, Bi2O3-NPs induced oxidative stress-related inflammation via activation of pro-inflammatory cytokine, IL-6. You may cite this article as : Oztas E, Abudayyak M, Aykanat B, Can Z, Baram E, Ozhan G (2019). Bismuth Oxide Nanoparticles Induced Oxidative Stress-Related Inflammation in SH-SY5Y Cell Line. Istanbul J Pharm 10.26650/IstanbulJPharm.2019. 19020.
Lessons in medical ethics

Age of medi cine is as old as the age of human on the earth. The doctor today is a scientist, technologist and healer at the same time. simple and uniform. Nor is the ethics simply a matter between the doctor and society with its entire economic and political dimension is involved in much bigger way. Certain basic traditional thoughts given by ancient Indian teachers like Hippocrates, Charaka, Sushrutha and Vagbhata are still become relevant. Medic as a normative discipline but as a practical course with its own problems and considerations. As per Indian outlook, the role of ethics is certainly vast and varied, from treating a common cold, to controversy on euthanasia, from the simple obligations of a family doctor, to the specialist services in the high cost, high technology five star nursing homes.
New horizons in the characterization and treatment of acute myeloid leukemia

division of Pediatric Oncology/Hematology (headed by prof.dr. G.J.L. Kaspers), in the setting of the VUmc Institute for Cancer and Immunology (V-ICI) at the VU university medical center, Amsterdam, the Netherlands. From June 2002 until May 2006 the research was performed at the laboratory of Pediatric Oncology/Hematology and from May 2006 onwards in the Hematology Laboratories of the Cancer Center Amsterdam (VUmc-CCA).
Physicochemical Characteristics and Antioxidant Capacity of Traditional Yogurt Fortified with Grape (Vitis vinifera L.) Seed Extract at Different Levels

Bu calismanin amaci, antioksidan aktivitesi yuksek uzum cekirdegi ekstrakti elde etmek ve farkli konsantrasyonlardaki cekirdek ekstraktlari ile takviye edilmis geleneksel yogurtlarin kalite ozelliklerini arastirilmasidir. Bu amacla ilk olarak sicak su ekstraksiyonu uygulanarak en yuksek antioksidan aktiviteye sahip Vitis vinifera L. uzum cekirdegi ekstrakti uretmek icin ekstraksiyon kosullari optimize edilmistir. Yogurtlarin zenginlestirilmesi 0.1 - 0.15 ve 0.2 g/100g ekstrakt duzeyinde yapilmistir. Yogurt numunelerinin antioksidan, fizikokimyasal, mikrobiyal ve duyusal ozellikleri analiz edilmistir. Sonuclara gore, zenginlestirilmis yogurt numunelerinin antioksidan aktivitesinin daha yuksek oldugunu ve kontrol numunelerine kiyasla % 14'e kadar daha fazla antioksidan aktivite gosterdikleri tespit edilmistir. Yogurt numunelerinin ise fizikokimyasal ozelliklerini korunmustur. Duyusal analizlerde 0.1 g / 100 g ekstrakt iceren ornekler genel kabul gormede en yuksek puana sahip olmasina ragmen, 0.2 g / 100 g iceren ornekler panelistlerce olumsuz algilanmistir. Sonuc olarak, uzum cekirdegi ekstrakti geleneksel yogurt uretiminde tat ve antioksidan ozelligini arttirmak icin kullanilabilir. 0.1-0.15 g / 100 g duzeyinde uzum cekirdegi ekstrakti ile zenginlestirme, fonksiyonel yogurt uretiminde makul olmakta ve olumlu saglik etkileri acisindan tuketicilerin begenisine daha fazla hitap etmektedir.
Physical Healthcare and Promotion in Mental Health Nursing

It is essential for mental health nurses to understand the physical health needs of people with mental health disorders in order to provide holistic care. Yet these people often have their physical health needs unrecognised or poorly managed. This book is a practical and informative guide to the physical health care of people with mental health illnesses. It covers a range of health-promotion strategies, including exercise, diet and oral health, and assessment, intervention and skills for common physical disorders found in people with mental-health problems. It takes a recovery perspective and emphasises the importance of communication and collaborative care for adherence to healthy lifestyles.
A primer on the diagnosis of child abuse and neglect

Child abuse and neglect is an international public health problem affecting all races, religions and socioeconomic groups. The World Health Organization (WHO) has defined child abuse as “all forms of physical and/or emotional ill-treatment, sexual abuse, neglect or negligent treatment or commercial or other exploitation resulting in actual or potential harm to the child’s health, survival, development or dignity in the context of a relationship of responsibility, trust, or power” [1]. Identifying abused children is challenging because abuse can take many forms and does not necessarily include physical injury. Child abuse affects children of all ages. Some physical abuse stems from child punishment for misbehaviours, which may take many forms and is influenced strongly by culture, societal views and tolerance of different forms of punishment [2]. The corporal punishment of children is tolerated in many countries and ranges from minor forms (slap on the buttocks) to more severe forms (e.g. caning and other injurious beatings). The purpose of this article is to provide some general structure to the identification and medical evaluation of suspected child abuse. Types of abuse
NATPGE: Understanding registered nurses' attitudes towards post graduate education

Nursing education is a dynamic process designed to enable nurses to competently meet the healthcare needs of society. Health system restructuring has been associated with diminishing postgraduate specialist nursing numbers worldwide. Valid instruments that monitor and evaluate nurses’ attitudes to gauge educational barriers and facilitators are a central component in planning effective education, and have been unavailable. Overall both the CE and the RNs ranked the NATPGE, using the CVI, as a realistic training platform that would be useful for evaluating RNs’ attitudes towards postgraduate education. The comments received from the CE resulted in some minor changes to the wording of some items for better clarity and simplicity. No particular concerns were raised about any of the items by the CE. The CE was agreeable that the items were arranged in a positively and negatively worded sequence, which was intentional as to prevent response bias. The present research indicates very good content and face validity and whilst the test-retest reliability overall was moderate, several individual questions did have poor kappa values.
Neurointensive Care Unit and neurointensivist: Do we need them?

has established that as a result of care by a dedicated neurointensivist in NICU charged with managing all aspects of these patients (as opposed to care provided in general ICU), victims of TBI, haemorrhagic stroke and subarachnoid haemorrhage have lower mortality, better functional outcome and reduced length of stay. The team‐based approach using neurointensivist to manage neurosurgical subarachnoid haemorrhage patients, merits further study of a successful model of care. [2] This improved outcome may not benefit patients of intracranial haematoma who tend to have poor outcomes regardless of the presence of a neurocritical care unit and neurointensivist. [3] Recent data have highlighted favourable outcome and lower mortality in neurosurgical patients attended to by a team of devoted neurointensivists. [4,5] It is now known that neurological/neurosurgical patients undergo more invasive intracranial and haemodynamic monitoring, tracheostomy and nutritional support and receive less intravenous sedation than patients in general ICU. [6] In addition, management of these patients in NICU results in lower cost of care than a National Benchmark of USA. [7]
Mémoire et viellissement: Modifications objectives, autoévaluation et facteurs biologiques

Cet article regroupe des resultats d'une enquete effectuee aupres de 442 personnes âgees, entre 65 et 93 ans, sur les themes suivants : a) changements correles avec l'âge intervenants au niveau de differentes fonctions de la memoire ; b) relation entre la performance objective de la memoire et l'auto-evaluation; c) facteurs biologiques ayant une influence sur differentes fonctions de la memoire. Les resultats demontrent que la capacite de la memoire de travail, le pouvoir episodique de recouvrement et la performance de la memoire a long terme sont fortement lies a l'avance en âge, alors que l'exploitation automatique de l'experience n'est pas touchee. On peut constater que les personnes âgees sont en mesure d'apprecier avec realisme leurs performances. Des variables biologiques (vitamine C, betacarotene, ferritine, force musculaire) ont en outre une valeur de prediction significative au niveau de differents parametres de la memoire.
Carbon nanotubes accelerated growth by iron nanoparticles under microwave heating

Abstract In this paper, the rapid growth characteristics of CNTs synthesized by microwave (MW) heating of ferrocene and graphite powders under argon atmosphere were investigated. The SEM and TEM results show that most of the iron nanoparticle (NPs) catalysts exhibited aggregated morphology. Meanwhile, dense clusters of CNTs with the maximum length up to 30 μm are formed on the aggregation of Fe NPs under MW-irradiation 30 seconds, while from the dispersed Fe NPs in general are carbon nano-onions, short and fine CNTs. Therefore, the rapid growth of the CNTs is associated with the aggregated morphology and the subsequent coalescent process of iron NPs. It is speculated that the formation of the growth sites of CNTs provided on the Fe NPs during the coalescence of them is a crucial factor for the ultrafast growth of CNTs.
Early Experience with a Modern Generation Knee System: Average 2 Years’ Follow-up

Arthritis in the knee is a leading cause of pain and disability with total knee arthroplasty (TKA) often the treatment of choice after failure of more conservative treatments. TKA has been demonstrated to be one of the most successful procedures performed. However, despite the good long-term survivorship rates, patient satisfaction is still an issue post TKA with over 20% of patients exhibiting patient dissatisfaction most commonly due to anterior knee pain (over 18-28% patients) and mediolateral or varus-valgus instability. Recent studies have demonstrated that collateral ligament strains are altered post TKA which may lead to laxity and/or tightness of the ligaments resulting in patient discomfort, pain, stiffness and/or instability post TKA. As a result, it may be beneficial to ensure ligamentous strains after TKA are similar or close to the native situation. The purpose of this study was to evaluate the clinical and radiographic results of the Unity Knee™ Total Knee System (Corin Ltd, Cirencester, UK), a modern generation, single-radius total knee replacement (TKR) and its accompanying instrumentation which is designed to help maintain proper ligament balance and restore the medial jointline. A total of 89 knees (89 patients) were implanted with the device in a single surgeon series. All patients were assessed using the American Knee Society Score (AKSS), the Oxford Knee Score (OKS), and radiographs. There was 1 revision due to infection and Kaplan-Meier survivorship was 98.9% at 2 years. The mean AKSS knee score for the total cohort was 87.1 ± 7.98 and the mean Oxford Knee score was 45.89 + 3.69. Radiographic review found no signs of radiographic failure in any of the knees. This study demonstrates good survivorship, clinical, and radiographic results at 2 years for this TKR.
Développement pubertaire et fonction ovarienne après greffe rénale chez la petite fille

But de l’etude : evaluation du deroulement pubertaire et de la fonction ovarienne apres greffe renale chez la petite fille. Patients et methodes : Etude monocentrique, retrospective et partiellement prospective. Dix-neuf patientes âgees de 19.6±4.2 ans et greffees renales avant 16 ans ont consulte a l’hopital pediatrique Necker-Enfants Malades (APHP) a Paris de septembre 2014 a janvier 2015. Les donnees sur le deroulement pubertaire, la croissance, la fonction renale et les traitements ont ete analysees. De maniere prospective, un bilan hormonal a ete preleve. Resultats : L’âge moyen du debut de la puberte (S2) etait de 12.6±1.9 (10-16) ans et l’âge moyen de la menarche de 14.5±1.6 (12.5-17.5) ans. La taille finale etait significativement abaissee par rapport a la taille cible (-1 DS±1.73 n=16 vs +0.67 DS±0.93 n=19, p=0.0035). Toutes recevaient un traitement immunosuppresseur avec un inhibiteur de la calcineurine, un anti metabolite et des corticoides. Ni l’âge a la transplantation, ni la dose de corticoides ou la fonction renale au moment de la puberte n’influencaient significativement l’âge du S2 ou l’âge de la menarche. Cinq des 10 jeunes filles sans traitement hormonal presentaient des troubles du cycle : 3 des menorragies, 1 une amenorrhee, 1 une spaniomenorrhee. Les taux plasmatiques medians de FSH etaient de 5.2±2.75 (2.8-96) UI/L n=8. Trois patientes avaient des taux plasmatiques d’AMH inferieurs a 1 ng/ml, une de ces patientes avait une FSH a 96UI/L. La moitie des jeunes filles a qui une vaccination HPV a ete proposee ont accepte de la faire. Conclusion : Dans notre cohorte de jeunes filles greffees renales avant l’âge de 16 ans, le deroulement pubertaire s’est effectue de maniere normale avec un âge a la menarche legerement superieur a celui rapporte dans la population generale. Meme si elle semble globalement conservee, la fonction ovarienne peut etre alteree. L’evaluation de la sante osseuse en fin de croissance et de la fonction ovarienne fait partie du suivi gynecologique de la jeune fille greffee renale.
EFFECTS OF ANETHUM ON BLOOD TRIGLYCERIDE, CHOLESTEROL AND LIPOPROTEINS IN COMPARISON TO GEMFIBROZIL

با توجه به عوارض داروهای سنتتیک و اینکه استفاده از داروهای گیاهی پذیرش بیشتری در بین بیماران دارد، در این مطالعه، بر آن شدیم تا تاثیر آنتوم (داروی گیاهی) که به عنوان داروی پایین آورنده چربی خون در سالهای اخیر در ایران مورد استفاده قرار گرفته است بر تری گلیسیرید، کلسترول و لیپوپروتئین های خون در مقایسه با ژمفیبروزیل و همچنین تعیین عوارض ناشی از این دو دارو را در بیماران داوطلب بررسی کنیم. این مطالعه به صورت مداخله ای بر روی 77 بیمار داوطلب مبتلا به هیپرلیپیدمی که به صورت تصادفی به دو گروه تقسیم شدند، انجام شده است. گروه اول ژمفیبروزیل (900 میلی گرم روزانه) و گروه دیگر آنتوم (6 قرص روزانه) دریافت کردند و پس از دو ماه درمان، لیپیدهای خون اندازه گیری شد. آنتوم، کلسترول توتال را 18 و تری گلیسیرید را 38/7 کاهش داد و بر HDL تاثیری نداشت. ژمفیبروزیل تری کلیسیرید را 7/32 و کلسترول توتال را 41/9 کاهش وHDL را 91/3 افزایش داد. در این مطالعه ژمفیبروزیل تری گلیسرید را بیشتر از آنتوم کاهش (05/0 P
Aktivitas Antioksidan Ekstrak Etanol Umbi Sarang Semut (Myrmecodia tuberosaJack.)Terhadap Kadar SOD (Superoxide Dismutase) Dan MDA (Malonildiadehide) Sel Darah Merah Domba

ABSTRAK Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan umbi sarang semut ( Myrmecodia Tuberosa Jack). Umbi sarang semut di ekstraksi menggunakan etanol 80% secara maserasi dan dilakukan pengujian karakteristik ekstrak meliputi nilai rendemen, kadar air, dan skrining awal fitokimia. Uji aktivitas antioksidan di lakukan secara in vitro dengan mengukur kadar S uperox ide dismutase (SOD) dan Malonildialdehid e (MDA) sel darah merah domba pada 6 kelompok perlakuan, yaitu: kelompok kontrol normal, kontrol negatif, kontrol positif (vitamin C), ekstrak dosis 0,6mg/ml, 1,2 mg/ml, dan 2,4 mg/ml. Hasil penelitian terhadap karakteristiik ekstrak menunjukan ekstrak memiliki nilai rendemen 19,63%, susut pengeringan 12,26%, dengan kandungan kimia alkaloid, flavonoid, terpenoid, saponin. Hasil pemeriksaan kadar SOD dan MDA menunjukan semua dosis ekstrak dapat meningkatkan kadar SOD dan menurunkan kadar MDA yang sebanding dengan vitamin C (P<0,05). K ata kunci : Myrmecodia t uberosa , antioksidan, S uperox ide dismutase , Malonildialdehid e , Sel darah merah domba ABSTRACT The aim of this research was to determine the antioxidant activity of ant nest bulb ( Myrmecodia Tuberosa Jack). Ant nest bulb was extracted using ethanol 80% by maceration and was tested for the characteristic of extract, especiallyyield of the extract, lost on drying, and preliminary phytochemical screening. Antioxidant activity was carried out in vitro by measuring the levels ofS uperox ide dismutase (SOD) and Malonildialdehid e (MDA) sheep's red blood cells in 6 treatment groups: normal control group, positive control (vitamin C), extract dose 0.6 mg/ml, 1.2 mg/ml, and 2.4 mg/ml. The result for characteristic of the extract showed that yield of extraction was 19.63%, lost on drying was 12.26%, and the chemical content of the extract were alkaloids, flavonoids, terpenoids, and saponins. The examination of SOD and MDA levels showed that all doses of the extract can increase SOD levels and lower MDA levels comparable to vitamin C (P < 0.05). Keyword : Myrmecodia t uberosa, antioxidant, S uperox ide dismutase, Malonildialdehid e , Sheep Red Blood Cells
Development of split luciferase complementation probes sensing KRAS/effector interaction

KRAS is the most frequently mutated oncogene in human cancers. Clinically effective therapy targeting KRAS, however, has not been developed to date despite the decades of intensive efforts. Among various therapeutic approaches taken, blocking the interaction between KRAS and the effector proteins is one of the effective strategies to inhibit KRAS signaling in diseases. Here we have developed the highly-sensitive split ELuc (Emerald Luc, an enhanced luciferase from click beetle) probes which detect the interaction between KRAS (wild-type, G12C and G12D active mutants) and the effector proteins such as BRAF, CRAF, and three RalGEFs (RalGDS, RGL2, and RGL3). The probe pairs transiently co-transfected into 293T cells yielded significantly strong luminescence signals in all combination of KRAS and effector probes but not with negative control probes, indicating the specificity and the sensitivity of the probes. As expected, KRAS G12C and G12D active mutant probes yielded higher signals than KRAS wild-type probe in any combination with effector probes. The novel probe systems described here will be useful tools for the discovery of KRAS genotype- or effector-specific inhibitors. The developed probes were able to detect KRAS/effector interaction in cells with high sensitivity and specificity in the microplate format, suggesting the application of this assay system to high-throughput screen to identify compounds affecting KRAS/ effector interaction. Since any combination of KRAS (wild-type, G12C, G12D) and effector (BRAF, CRAF, RalGDS, RGL2, RGL3) probes yielded the strong signal, our assay probes will be a useful tool to develop KRAS genotype- or effector-specific inhibitors.
The potential function and clinical application of FGF21 in metabolic diseases

As an endocrine hormone, fibroblast growth factor 21 (FGF21) plays a crucial role in regulating lipid, glucose, and energy metabolism. Endogenous FGF21 is generated by multiple cell types but acts on restricted effector tissues, including the brain, adipose tissue, liver, heart, and skeletal muscle. Intervention with FGF21 in rodents or non-human primates has shown significant pharmacological effects on a range of metabolic dysfunctions, including weight loss and improvement of hyperglycemia, hyperlipidemia, insulin resistance, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD). Due to the poor pharmacokinetic and biophysical characteristics of native FGF21, long-acting FGF21 analogs and FGF21 receptor agonists have been developed for the treatment of metabolic dysfunction. Clinical trials of several FGF21-based drugs have been performed and shown good safety, tolerance, and efficacy. Here we review the actions of FGF21 and summarize the associated clinical trials in obesity, type 2 diabetes mellitus (T2DM), and NAFLD, to help understand and promote the development of efficient treatment for metabolic diseases via targeting FGF21.