Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased risk of acute pancreatitis in patients with sjögren syndrome: A nationwide population-based cohort study

Background: Sjögren's syndrome (SS) is a chronic autoimmune disease with lymphocytic exocrine gland infiltration causing dry mouth and eyes. The disease can develop alone (primary SS, PSS) or with other autoimmune diseases (secondary SS, SSS). PSS has been suggested to increase the acute pancreatitis risk. However, whether all patients with SS share this higher risk remains uncertain. This nationwide population-based cohort study aimed to detect associations between SS and acute pancreatitis. Methods: We identified 11,922 individuals with SS cohort and 47,688 individuals without SS (non-SS cohort) between 2000 and 2010 from the Taiwan National Health Insurance database. We matched the individuals between the SS and non-SS cohorts according to age, gender, and index year at a 1:4 ratio. We used a Cox multivariable proportional-hazards model to determine the effects of SS on the acute pancreatitis risk. Results: The SS cohort had a higher acute pancreatitis risk than the non-SS cohort after covariate adjustments (adjusted hazard ratio [HR], 3.374; 95% confidence interval [CI], 2.869–3.969). Patients with PSS exhibited a 2.872-fold risk (95% CI, 2.611–3.901) and patients with SSS a 4.121-fold risk (95% CI, 3.752–5.124) for acute pancreatitis. Our subgroup analyses revealed that patients with SS and systemic lupus erythematosus (adjusted HR, 3.85; 95% CI, 3.259–4.999), rheumatoid arthritis (adjusted HR, 4.298; 95% CI, 3.862–5.286), systemic sclerosis (adjusted HR, 2.765; 95% CI, 2.26–3.68), or polymyositis (adjusted HR, 2.641; 95% CI,1.847–3.101) and dermatomyositis (adjusted HR, 3.77; 95% CI, 2.894–4.502) had higher acute pancreatitis risk. Conclusions: Patients with SS presented increased acute pancreatitis risks than patients without SS, and patients with SSS had higher acute pancreatitis risks than patients with PSS. Physicians should be aware of this increased risk in patients with SS.
Psychiatric Symptoms and Help-Seeking Behavior Among the Elderly: An Analysis of Racial and Gender Differences

This study of randomly selected black (N = 600) and white (N = 600) elderly individuals residing in Nashville, TN, ex- amines the relationship between psychiatric symptoms and utiliza- tion of both formal and informal resources of help among the black and white elderly. Relevant data were collected through face-to-face interviews with the elderly living either in their own homes or in the high-rise apartments for the elderly. Analyses of data show that significantly greater proporlions of the elderly with psychiatric symptoms in both samples use mental health professionals. Mental health services, however, were less frequently used as compared to the family physician or seeing the clergyman. Furthermore, in both samples, help from clergy, fnends/relatives or praying frequently was higher among the females than males. The elderly males tended to use drinking more than usual and going out for long walks as coping mechanisms. A discussion of these fmdings is provided.
Contaminação microbiológica de nebulizadores usados por pacientes com fibrose cística: um problema subestimado

Objetivo: Nebulizadores caseiros são usados rotineiramente no tratamento de pacientes com fibrose cística (FC). Este estudo objetiva avaliar a contaminação de nebulizadores utilizados por pacientes de FC que estão cronicamente colonizados por Pseudomonas aeruginosa e a associação da contaminação do nebulizador com a higienização, esterilização e método de secagem. Métodos: Um estudo transversal, observacional, multicêntrico foi conduzido em sete centros de referência de FC no Brasil para obter dados de registros médicos; foram feitas entrevistas estruturadas com os pacientes/ cuidadores e partes de nebulizadores (máscara e copo) foram coletados para cultura microbiológica. Resultados: No geral, 77 pacientes com FC foram incluídos. A frequência da contaminação do nebulizador foi de 71,6%. Candida spp. (52,9%), Stenotrophomonas maltophilia (11,9%), P. aeruginosa não mucoide (4,8%), Staphylococcus aureus (4,8%) e complexo Burkholderia cepacia (2.4%) foram os patógenos isolados mais comuns. A frequência de higienização dos nebulizadores foi de 97,4%, e 70,3% dos pacientes relata higienização, esterilização e secagem dos aparelhos. A lavagem com água da torneira e secagem das partes no tempo, em espaço aberto, aumentou significativamente (9 a 10 vezes) a chance de contaminação dos nebulizadores. Conclusões: Apesar dos relatos de frequente higienização dos nebulizadores, os métodos de limpeza e esterilização usados eram inadequados. Uma proporção significativa de nebulizadores foi contaminada com microrganismos potencialmente patogênicos para pacientes com FC. Estes resultados apoiam a necessidade de inclusão dos pacientes/cuidadores em programas educacionais e/ou novas estratégias para fornecimento de antibióticos inalatórios.
Chemoimmunotherapy combination: Potential option for metastatic NSCLC patients with EGFR mutation resistant to osimertinib.

e20618 Background: Osimertinib has been emerged as the standard selection in EGFR T790M-positive NSCLC patients who failed prior treatment with EGFR TKIs. However, acquired resistance to osimertinib is a growing clinical challenge. Despite the significant antitumor activity of Chemoimmunotherapy (CIT) combinations in NSCLC, clinical benefit in patients with EGFR mutations has not been shown obviously. Our objective was to assess the effectiveness and tolerability of CIT for metastatic EGFR-mutant NSCLC patients with acquired resistance to Osimertinib. Methods: We conducted a retrospective study in patients with sensitizing EGFR-mutant NSCLC who were resistant to Osimertinib and received anti-PD1 immunotherapy combined with chemotherapy at Chinese PLA General Hospital. Progression-free survival (PFS), overall survival (OS), overall response rate (ORR), and toxicities were examined. Results: Between Oct 2015 and Nov 2018, 11 patients were available for analysis, 45.5% male, 45.5% ECOG PS 0-1, median age 54 years, all pts who failed treatment with Osimertinib had received previously targeted therapies. In this CIT combination group, 6 [54.5%] of 11 pts received pembrolizumab and 5[54.5%] of 11 pts received Nivolumab anti-PD1 therapy, 8 [72.7%] of 11 pts received mono-chemotherapy and 3 [27.3%] of 11 pts received platinum-based doublet chemotherapy. The median PFS was 7.47 months (95% CI 3.04 to 11.89). Despite Median OS was not reached, the OS rate at one year was 6 [54.5%] of 11. The ORR was 5 [45.5%] of 11. Treatment-related adverse events (TRAE) of grade 3 or higher were reported in 6 [54.5%] of 11 patients. The most common grade 3 or worse TRAEs were fatigue (3 [27.3%] of 11) and anemia (3 [27.3%] of 11); The following ≥Grade 3 TRAEs occurred once: decreased neutrophil count, acute kidney injury, gastrointestinal bleeding. One patient discontinued treatment because of immune-associated gastroenteritis. Conclusions: In metastatic NSCLC patients with activating EGFR mutation resistant to Osimertinib, our single institution real-world experience in Chemoimmunotherapy combination shows promising activity and acceptable toxicity profile. Given the small number of patients studied, further clinical trials are warranted.
Expressions, emotions, and website design

The aim of the study was to investigate the relation between the design elements of web pages and (i) perceived usability, (ii) perceived expression and (iii) emotional responses. Two different websites, differing in content as well as in graphic design, colour schemes, the balance between text versus illustrations, etc., were evaluated in an experimental study involving altogether 20 subjects. Three main factors were identified that contributed to the perceived expression of the websites: graphic design; content; and perceived usability. Also the reported emotional responses appeared related to the same aspects.
A Study on Feature Extraction Techniques for Image Mosaicing System

In Image processing, mosaicing image is the combine two or more images of the same scene into one image. Image stitching "mosaicing" is the process of assembling images of the same scene into a large image. Image mosaicing/stitching is considered as an active research various applications such as photogrammetry, computer vision, remote sensing image processing, medical image analysis ,computer graphics etc. In this paper discuss a review of different feature extraction algorithms and compare the different extraction algorithms such as Harris corner detector, SIFT SURF, FAST, MSER, ORB detector etc.
Shakespeare's Unorthodox Biography: New Evidence of an Authorship Problem

Introduction Biographical Evidence What's the Question? Shakespeare's Footprints The Theatrical Scrapbook Inadmissible and Controversial Evidence Johannes Factotum Shake-speare in Sport Monstrous Theft The "Poet-Ape" Literary Paper Trails Misleading and Missing Evidence A Monument Without a Tomb The First Folio Shakespeare's Drinking Buddies Conspiracies and Chicanery Overwhelming Evidence Shakespere's Education Country Lad or Courtier Autobiographical "Echoes" Chronological Disorder A Playwright by Any Other Name Appendix Bibliography Index
Safety and Efficacy of Percutaneous Intraductal Radiofrequency Ablation Followed by Dual Stent Placement for Malignant Biliary Hilar Obstruction

창형 금속 스텐트를 사용하는 것이 바람직하다(3). 이론적으로 Purpose: To evaluate the safety and clinical efficacy of percutaneous intraductal radiofrequency ablation (RFA) followed by dual stent placement in advanced malignant biliary hilar duct obstruction. Materials and Methods: Between September 2013 and August 2015, ten patients with malignant biliary hilar duct obstruction who underwent percutaneous intraductal RFA followed by dual stent placement were included in this retrospective study. Technical success, clinical success, procedure-related complications, stent patency, and patient’s survival durations after treatment were investigated. Results: Percutaneous intraductal RFA followed by dual stent placement was successful in all patients; the technical success rate was 100%. No major complications were identified. After the procedure, serum total bilirubin levels were notably normalized, and therefore, percutaneous transhepatic biliary drainage (PTBD) catheter was successfully removed in 8 patients; the clinical success rate was 80%. Four patients with stent dysfunction associated with tumor ingrowth/overgrowth underwent a repeat PTBD procedure or secondary stent insertion. Mean stent patency and survival durations were 233.8 ± 35.6 days [95% confidence interval (CI), 164.0–303.5 days] and 387.2 ± 114.6 days (95% CI, 162.6–611.8 days), respectively. Conclusion: Percutaneous intraductal RFA combined with dual stent placement in advanced malignant biliary hilar duct obstruction is a safe and feasible palliative treatment option. Index terms Ablation Techniques Self Expandable Metallic Stents Bile Duct Neoplasms Cholestasis
A Survey on Various Approaches for Sentiment Analysis and Performance Optimization

:- Sentiment analysis, which is also known as opinion mining and is a part of text mining were we mine data to extract their opinion. People provide their opinion, comments, feedbacks and these are very important indicators. From opinion mining a company may get a feedback for their products from there users, so that they can improve it further on the basis of feedbacks. Politicians can also use it for analyze sentiment about their policies or some other political issues. This paper presents various technique used in the whole process of opinion mining and how different choices will affect our result. Here we will also see the problems that are still there in extracting the sentiment about a product.
Sistema de Vídeo-Vigilância sobre Ethernet com QoS Dinâmica

The use of multimedia applications within industrial systems has become commonplace. This integration derives from the need to improve both interaction between the system and the operators and the decision and control techniques. An example is process supervision with video which incorporates multimedia transmission and processing in a distributed environment. Normally, industrial systems rely on real-time network protocols, particularly Real Time-Ethernet (RTE), to provide low latency communication services. However the conventional RTE protocols offer Constant Bit-Rate (CBR) channels with static Quality of Service (QoS) management models, properties which conflict with the most common Variable Bit-Rate (VBR) nature of the multimedia traffic. This conflict makes the VBR to CBR adaptation difficult and increases the inefficiency on bandwidth usage. In this work a video surveillance application was developed, consisting of several cameras and a monitoring station. In this scenario the various cameras produce multimedia content which is sent to the monitoring station where the multiple streams can be viewed separately and where is possible to manage individually each stream’s QoS as well as the global QoS of the system. To accomplish this goal, this system used the FTT-SE network protocol that provides adaptable real time communication channels, which operational parameters can be changed at run time. The results show that this model of QoS management is appropriate for this type of scenario, and the implemented architecture provides a robust QoS management system.
Nucleus Pulposus Herniation

Nucleus pulposus herniation is the most common cause of sciatic pain and one of the most common indications for spine surgery worldwide. [1] This condition presents as a displacement of the nucleus pulposus beyond the intervertebral disc space. The disc anatomy consists of two main structures, the nucleus pulposus (NP) and the annulus fibrosus (AF). The nucleus pulposus is composed of water, type II collagen, chondrocyte-like cells, and proteoglycans. This unique composite allows the NP to be elastic, flexible under stress forces and to absorb compression. [2] The composition of the AF is mainly concentric layers of collagen type I fibers,[3] forming a fibrous tissue with helical disposition surrounding the NP, this structure is denser in the anterior part and is attached to the vertebral body by Sharpey fibers.
Conhecimento e importância atribuída a conteúdos curriculares de Patologia Oral por estudantes de Odontologia e cirurgiões-dentistas

This study aimed to evaluate the knowledge and importance attached to curricular contents of Oral Pathology by Dentistry students and dentists. The sample comprised 113 dentists and 55 senior Dentistry students in Rio de Janeiro /Brazil. Questionnaires and an exam form with ten multiple choice questions were applied to students and dentists. The responses were analysed on a descriptive perspective. The curricular contents of Oral Pathology considered the most rele¬vants were the viral and bacterial infections, the dental and oral structures development alterations and the pulpal and periapical pathologies.
Comparison of the effects of Purslane cream and Lanolin for treatment of Breast Fissure on Lactation Self-efficacy: A Randomized Clinical Trial

Introduction: Self-efficacy is an important motivating factor for success in lactation, so that increasing self-efficacy in the postpartum period leads to continued lactation. Performing lactation self-efficacy promotion interventions based on the sources of practical self-efficacy seems to be reasonable. Therefore, this study was performed with aim to compare the effect of Purslane cream and Lanolin for treatment of breast fissure on lactation self-efficacy. Methods: This double-blind randomized clinical trial was performed on 86 breastfeeding women with nipple fissure in Mashhad in 2016. The subjects were randomly assigned to two treatment groups of Purslane cream and Lanolin (n=43 in each group). Appropriate method of lactation and drug use were trained to both groups and they were asked to use treatment three times a day and up to one week. The score of nipple fissure was measured and recorded before the intervention, the third and eighth day after the intervention using the Store scale by the researcher. The tool of lactation self-efficacy was completed before the intervention and one day after treatment (8th day) through interview with the research units. Data were analyzed using SPSS software (version 22) and t-test, repeated measures variance analysis, Mann-Whitney, and Chi-square. PResults: According to the results of Mann-Whitney test, two groups were homogeneous in terms of mean score of fissure before the intervention, but there was significant difference between two groups on the third and eighth day (P <0.001). So that, recovery was faster observed in the Purslane creamgroup than Lanolin group. Self-efficacy score increased in both groups and this increase was significant in each group (P<0.001). However, this difference was not statistically significant when two groups were compared (P=0.434). Conclusion: Purslane cream in comparison with lanolin accelerated the recovery process of breast fissure and increased lactation self-efficacy score, although this difference was not significant.
64-bit reconfigurable adder for low power media processing

A new, highly reconfigurable carry-skip adder for media signal processing is presented. The proposed circuit can be partitioned to perform one 64-, two 32-, four 16- and eight 8-bit additions. Partitioning is obtained without increasing the critical path. When the AMS 0.35 /spl mu/m two-poly three-metal 3.3 V CMOS (CSD) process is used to produce the layout, the worst propagation delay and dissipation obtained is about 6.5 ns and 148 /spl mu/W/ MHz.
Interleukin-6 is potential target to de-couple checkpoint inhibitor-induced colitis from antitumor immunity.

2616 Background: A deep understanding of the immunobiology of checkpoint inhibitor (CPI) induced immune related toxicities, such as immune related enterocolitis (irEC), and how these compare to the immune signatures in tumors could lead to the development of strategies that de-couple autoimmunity from anti-tumor immunity. Methods: Total RNA from patient-matched irEC and normal colon FFPE tissue from patients [n = 12] receiving CPIs were profiled with the 770 gene NanoString nCounter PanCancer Immune Profiling Panel (NanoPCIP). The mean fold change in gene expression from normal vs. irEC inflamed colonic tissue and baseline vs. on-treatment tumor samples from patients responding or non-responding to ipilimumab based therapy were analyzed. C57BL/6 mice with B16.BL6 melanoma tumors were treated with systemic anti-IL-6 + anti-CTLA-4 vs. anti-CTLA4 alone vs. placebo and tumor size was measured. Results: In patients with irEC, the highest significantly upregulated differentially expressed gene (DEG) in inflamed colon tissue encoded for IL-6 (Fold change +24.1). None of the significant and highest upregulated DEGs in the colitis, including IL-6, were significantly upregulated in responding tumors. Interestingly, IL-6 was also the highest upregulated DEG in non-responding tumors numerically. When comparing mean fold changes across these analyses, the gene with the largest difference in upregulatation between colitis and responding tumors was IL-6; the other highest upregulated genes in colitis encoded for neutrophil and monocyte chemotactic molecules. In our mouse models, the addition of IL-6 blockade to anti-CTLA-4 therapy significantly improved tumor shrinkage compared to anti-CTLA-4 alone. Conclusions: Our data demonstrates that IL-6-mediated inflammation may be more prevalent in irEC and tumors not responding to CPIs than in tumors responding, and blocking IL-6 enhances CPI anti-melanoma activity. Targeting IL-6 may ameliorate irEC without hindering anti-tumor immunity.
Safety Implications of Low-Dose Amitriptyline in Neuropathic Pain

Background: Treatment guidelines in neuropathic pain list amitriptyline as a first-line option. Modest evidence on efficacy and safety concerns possibly shape the rationale behind dosing recommendations. An observational study was carried out to understand the usefulness of safety monitoring for this established medicine. Methods: Twenty-six (26) subjects were categorized into 2 groups: 13 patients under pain management receiving 10 mg amitriptyline daily for less than 12 months, and 13 patients under psychiatric care receiving a daily dose of 25–75 mg for over 12 months. Dose-related reference ranges were calculated and blood levels were assessed for the case examples presented. Adverse events and ECGs were collated. QT intervals were corrected using Bazett’s and Fridericia’s formulae. Side-effect frequencies were evaluated both within the research groups, and in the broader perspective of spontaneous ADR reporting through EudraVigilance. Results: The applicability of dose-related reference ranges, considering confounding factors such as drug interactions and metabolizer status, is discussed. Patients in both groups reported on average three side-effects, with drowsiness being reported more significantly in the 10 mg group and possibly attenuating with time; an observation not replicated for dry mouth. ADR reports with non-granulated information limit the usefulness of the data retrieved. Comparison of QT corrected with Bazett’s and Fridericia’s formulae suggests that Bazett’s may overestimate the number of patients on amitriptyline with QTc prolongation. Conclusions: This research supports the adoption of evolving research observations to understand the implications of dosing recommendations and safety assessments in attempt of delivering individualized treatment with minimal risk
A Microarray Cluster Algorithm Based on Dominant Set Segmentation

Clustering algorithms are wildly used in the research of microarray data to extract groups of genes or samples that are tightly coexpressed. In most of them, some parameters should be predefined artificially, however, it is very difficult to determine them manually without prior domain knowledge. To handle this problem, an iterative clustering algorithm is proposed. Firstly, by sorting the original data by dominant set, similar genes would be aligned together. It’s hard to specify the cluster boundary. A criterion is presented to partition a cluster from the sorted data according to the property that the distances between the inside elements are smaller than that of outside elements. The idea is to remove the cluster form the current data set, repeat the process, and stop the algorithm when the stop criterions are satisfied. The new clustering algorithm is analyzed on several aspects and tested on the published yeast cell-cycle microarray data. The results of the application confirm that the method is very applicable, efficient and has good ability to resist noise.