Miracle-dz/UniFAR-FTUs huggingface dataset:
Results of a pilot intervention trial to improve antiretroviral adherence among HIV-positive patients.

A small pilot trial of a multicomponent (behavioral strategies, simplified patient information, and social support) and multidisciplinary (cognitive-behavioral therapy and nursing) medication adherence intervention was conducted for HIV-infected adults prescribed antiretrovirals. Patients (N = 33) were randomly assigned to the intervention condition or standard care. Compared to the control group, patients in the intervention condition had significantly higher self-efficacy to communicate with clinic staff (p = .04) and to continue treatment (p = .04), were significantly more likely to be using behavioral and cognitive strategies (p = .01 and p = .04), reported significantly higher life satisfaction (p = .03), reported significantly increased feelings of social support (p = .04), and showed a trend toward an increase in taking their medications on schedule (p = .06). The intervention, however, did not appear to affect health-related anxiety or to significantly improve adherence to dose. Implications for future intervention planning are discussed.
Social isolation, loneliness, and all-cause mortality in older men and women

Both social isolation and loneliness are associated with increased mortality, but it is uncertain whether their effects are independent or whether loneliness represents the emotional pathway through which social isolation impairs health. We therefore assessed the extent to which the association between social isolation and mortality is mediated by loneliness. We assessed social isolation in terms of contact with family and friends and participation in civic organizations in 6,500 men and women aged 52 and older who took part in the English Longitudinal Study of Ageing in 2004–2005. A standard questionnaire measure of loneliness was administered also. We monitored all-cause mortality up to March 2012 (mean follow-up 7.25 y) and analyzed results using Cox proportional hazards regression. We found that mortality was higher among more socially isolated and more lonely participants. However, after adjusting statistically for demographic factors and baseline health, social isolation remained significantly associated with mortality (hazard ratio 1.26, 95% confidence interval, 1.08–1.48 for the top quintile of isolation), but loneliness did not (hazard ratio 0.92, 95% confidence interval, 0.78–1.09). The association of social isolation with mortality was unchanged when loneliness was included in the model. Both social isolation and loneliness were associated with increased mortality. However, the effect of loneliness was not independent of demographic characteristics or health problems and did not contribute to the risk associated with social isolation. Although both isolation and loneliness impair quality of life and well-being, efforts to reduce isolation are likely to be more relevant to mortality.
Regulatory Monoubiquitination of Phosphoenolpyruvate Carboxylase in Germinating Castor Oil Seeds*♦

Phosphoenolpyruvate carboxylase (PEPC) is a tightly regulated enzyme situated at the core of plant C-metabolism. Although its anaplerotic role and control by allosteric effectors, reversible phosphorylation, and oligomerization have been well documented in the endosperm of developing castor oil seeds (COS), relatively little is known about PEPC in germinating COS. The initial phase of COS germination was accompanied by elevated PEPC activity and accumulation of comparable amounts of pre-existing 107-kDa and inducible 110-kDa immunoreactive PEPC polypeptides (p107 and p110, respectively). A 440-kDa PEPC heterotetramer composed of an equivalent ratio of non-phosphorylated p110 and p107 subunits was purified from germinated COS. N-terminal microsequencing, mass spectrometry, and immunoblotting revealed that both subunits arose from the same gene (RcPpc3) that encodes the p107 subunit of a phosphorylated 410-kDa PEPC homotetramer in developing COS but that p110 is a monoubiquitinated form of p107. Tandem mass spectrometry sequencing of a diglycinated tryptic peptide identified Lys-628 as p110's monoubiquitination site. This residue is conserved in vascular plant PEPCs and is proximal to a PEP-binding/catalytic domain. Incubation with a human deubiquitinating enzyme (USP-2 core) converted the p110:p107 PEPC heterotetramer into a p107 homotetramer while significantly reducing the enzyme's Km(PEP) and sensitivity to allosteric activators (hexose-Ps, glycerol-3-P) and inhibitors (malate, aspartate). Monoubiquitination is a non-destructive and reversible post-translational modification involved in the control of diverse processes such as transcription, endocytosis, and signal transduction. The current study demonstrates that tissue-specific monoubiquitination of a metabolic enzyme can also occur and that this modification influences its kinetic and regulatory properties.
The mouse pericardium: It allows passage of particulate matter from the pleural to the pericardial cavity

Frog erythrocytes injected into the pleural cavity of mice reached the pericardial cavity. Pericardial pores that connect the two cavities were the routes of the migration. As soon as 5 minutes after injection, frog erythrocytes were surrounded and phagocytosed by attached macrophages in milky spots facing the pericardial cavity. The pericardial pores may function in an allied self‐defense mechanism between the pleural and pericardial cavities in this species.
Characterizing large earthquakes before rupture is complete

The early stages of M7 to M9 earthquakes show that large events can be distinguished from larger ones well before rupture is complete. Whether earthquakes of different sizes are distinguishable early in their rupture process is a subject of debate. Studies have shown that the frequency content of radiated seismic energy in the first seconds of earthquakes scales with magnitude, implying determinism. Other studies have shown that recordings of ground displacement from small to moderate-sized earthquakes are indistinguishable, implying a universal early rupture process. Regardless of how earthquakes start, events of different sizes must be distinguishable at some point. If that difference occurs before the rupture duration of the smaller event, this implies some level of determinism. We show through analysis of a database of source time functions and near-source displacement records that, after an initiation phase, ruptures of M7 to M9 earthquakes organize into a slip pulse, the kinematic properties of which scale with magnitude. Hence, early in the rupture process—after about 10 s—large and very large earthquakes can be distinguished.
Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: relevance to inflammation in rheumatoid arthritis.

OBJECTIVE To investigate the in vitro effect of activated protein C (APC), a natural anticoagulant and novel antiinflammatory agent, on the regulation of the gelatinases matrix metalloproteinase 2 (MMP-2) and MMP-9. METHODS Synovial fibroblasts and peripheral blood monocytes isolated from patients with rheumatoid arthritis (RA) or osteoarthritis (OA) and Mono Mac6 cells were used in this study. After treatment, cells and culture supernatants were collected for zymography, enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, and Western blot analysis. RESULTS Fibroblasts and monocytes from RA patients produced substantially more MMP-9 than did those from OA patients; however, there was no difference in MMP-2 production. The addition of recombinant APC markedly reduced MMP-9 at the gene and protein levels. In contrast, APC up-regulated and activated MMP-2. Using a blocking antibody to the endothelial protein C receptor (EPCR), we showed that the inhibition of MMP-9 by APC was EPCR-dependent. Furthermore, APC directly suppressed the production of tumor necrosis factor (TNF) and the activation of NF-kappaB and MAP kinase p38, and inhibitors of NF-kappaB or p38 reduced the production of MMP-9, suggesting that APC inhibits MMP-9 by blocking TNF, NF-kappaB, and p38. Thus, APC acts on MMP-9 by binding to EPCRs on the cell surface and, subsequently, inhibiting the intracellular activation of the proinflammatory signaling molecules NF-kappaB and p38. CONCLUSION APC appears to be the first physiologic agent to inhibit the production of proinflammatory MMP-9, yet increase antiinflammatory MMP-2 activity. Our results provide the initial evidence that APC may be beneficial in the prevention of inflammation and joint destruction in RA.
A four-channel analysis of the tactile sensitivity of the fingertip: frequency selectivity, spatial summation, and temporal summation

Thresholds were measured for the detection of vibratory stimuli of variable frequency and duration applied to the index fingertip and thenar eminence through contactors of different sizes. The effects of stimulus frequency could be accounted for by the frequency characteristics of the Pacinian (P), non-Pacinian (NP) I, and NP III channels previously determined for the thenar eminence (Bolanowski et al., J Acoust Soc Am 84 : 1680-1694, 1988; Gescheider et al., Somatosens Mot Res 18: 191- 201, 2001). The effect of changing stimulus duration was also essentially identical for both sites, demonstrating the same amount of temporal summation in the P channel. Although the effect of changing stimulus frequency and changing stimulus duration did not differ for the two sites, the effect of varying the size of the stimulus was significantly greater for the thenar eminence than for the fingertip. The attenuated amount of spatial summation on the fingertip was interpreted as an indication that the mechanism of spatial summation consists of the operations of both neural integration and probability summation.
Effectiveness and cost-effectiveness of echocardiography and carotid imaging in the management of stroke.

Specific interventions included in the review Studies of imaging strategies were eligible for inclusion: transthoracic echocardiography (TTE), transoesophageal echocardiography (TEE), carotid ultrasound (CUS), magnetic resonance imaging (MRA) and cerebral angiography. Other ultrasonic strategies and noninvasive carotid imaging techniques were excluded. The review also investigated the efficacy and safety of carotid endarterectomy (CEA) following carotid imaging.
Developmental Phenotype of a Membrane Only Estrogen Receptor α (MOER) Mouse*

Estrogen receptors (ERs) α and β exist as nuclear, cytoplasmic, and membrane cellular pools in a wide variety of organs. The relative contributions of each ERα pool to in vivo phenotypes resulting from estrogen signaling have not been determined. To address this, we generated a transgenic mouse expressing only a functional E domain of ERα at the plasma membrane (MOER). Cells isolated from many organs showed membrane only localized E domain of ERα and no other receptor pools. Liver cells from MOER and wild type mice responded to 17-β-estradiol (E2) with comparable activation of ERK and phosphatidylinositol 3-kinase, not seen in cells from ERαKO mice. Mating the MOER female mice with proven male wild type breeders produced no pregnancies because the uterus and vagina of the MOER female mice were extremely atrophic. Ovaries of MOER and homozygous Strasbourg ERαKO mice showed multiple hemorrhagic cysts and no corpus luteum, and the mammary gland development in both MOER and ERαKO mice was rudimentary. Despite elevated serum E2 levels, serum LH was not suppressed, and prolactin levels were low in MOER mice. MOER and Strasbourg female mice showed plentiful abdominal visceral and other depots of fat and increased body weight compared to wild type mice despite comparable food consumption. These results provide strong evidence that the normal development and adult functions of important organs in female mice requires nuclear ERα and is not rescued by membrane ERα domain expression alone.
Control of Glycopeptide‐Resistant Enterococci in an Oncology Unit

Enterococci are responsible for 10–12% of nosocomial infections. Since 1987 the incidence of glycopeptide‐resistant enterococci (GRE; termed vancomycin‐resistant enterococci in the United States) has increased dramatically. The mechanism of GRE is well understood and involves mutation of a single terminal amino acid in a peptidoglycan precursor leading to reduced vancomycin affinity. Studies implicated antibiotic selection pressure as a major risk factor for GRE infection and colonization. In the hematology unit of a London hospital, GRE emerged in December 1993, with 38% of patients positive in a point prevalence study. Between December 1993 and June 1995, 13 patients acquired GRE bacteremia, five of whom died. Between 1995 and 1996 a prospective sequential study was undertaken to determine the effect of changing antibiotic treatment of febrile neutropenia (FN). All patients admitted to the hematology unit were enrolled in the study. In phase 1, treatment continued with ceftazidime monotherapy. In phase 2, piperacillin‐tazobactam replaced ceftazidime, and enhanced infection control measures were encouraged. In phase 3, therapy returned to ceftazidime. In phase 1, 57% of patients became colonized or infected with GRE. Phase 2, which was divided into two 4‐month cohorts, showed a significant reduction in GRE acquisition, falling to 8% colonization and no clinical infections in the second 4 months. In phase 3, despite heightened infection control procedures, the acquisition rate rose to 36%.
Differential barometry in personal navigation

In many personal navigation applications accurate altitude information is required. Finding a correct floor in a tall building or precise guidance in multi-layer intersection is not possible with two-dimensional navigation system. Satellite navigation systems provide altitude information, but accuracy is not necessarily sufficient for this kind of situations. Barometers can be used to improve the accuracy and availability of the altitude solution. The objective of this study was to find relevant error sources of barometer based altitude in the context of personal navigation. MEMS barometer data were collected in several scenarios where different disturbances affect the pressure reading. To separate error sources, reference barometer at known altitude was used. The results show that barometers in differential mode provide highly accurate altitude solution, but local disturbances in pressure need to be taken into account in the application design.
Modeling of two-dimensional dynamic temperature distribution of a LPCVD process and control design by MPC

Low pressure chemical vapor deposition (LPCVD) is a familiar method for thin film growing in semiconductor manufacture. The surface temperature of wafers is studied in this work which plays the most important role in impacting the film's thickness and roughness. The calculation of configuration factors which are the key varibles in LPCVD process thermal modeling is shown. Then, the two-dimensional dynamic model of temperature distribution of wafers is established by studying the radiation and conduction in the depositing furnace. The result of this simulation model is compared with which in reference article. Finally, the temperature distribution is controlled to keep it uniform by predict control designing.
Alignment and precession of a black hole misaligned with its accretion disc: application to low-mass X-ray binaries

A thin viscous accretion disc around a Kerr black hole, which is warped due to the Lense-Thirring (LT) effect, was shown to cause the spin axis of the black hole to precess and align with the outer disc. We calculate the total LT torque acting on the black hole, and compute the alignment and precession time-scales for both persistent and transient accretors. In our analysis, we consider the contribution of the inner disc, as it can stay misaligned with the black hole spin for a reasonable range of parameter values. We find that the alignment time-scale increases with a decrease in the Kerr parameter below a critical Kerr parameter value, contrary to earlier predictions. Besides, the time-scales are generally longer for transience than the time-scales calculated for persistent accretion. From our analysis of the transient case, we find that the black hole in the low mass X-ray binary (LMXB) 4U 1543-47 could be misaligned, whereas that in the LMXB XTE J1550-564 has aligned itself with the outer disc. The age of the LMXB H 1743-322 is estimated assuming a misaligned disc. We also find that the black hole in a typical Galactic LMXB can take a significantly longer time to align than what was estimated in the past. This may have an important implication on the measurement of black hole spin using the continuum X-ray spectral fitting method.
Align-and-Attend Network for Globally and Locally Coherent Video Inpainting

We propose a novel feed-forward network for video inpainting. We use a set of sampled video frames as the reference to take visible contents to fill the hole of a target frame. Our video inpainting network consists of two stages. The first stage is an alignment module that uses computed homographies between the reference frames and the target frame. The visible patches are then aggregated based on the frame similarity to fill in the target holes roughly. The second stage is a non-local attention module that matches the generated patches with known reference patches (in space and time) to refine the previous global alignment stage. Both stages consist of large spatial-temporal window size for the reference and thus enable modeling long-range correlations between distant information and the hole regions. Therefore, even challenging scenes with large or slowly moving holes can be handled, which have been hardly modeled by existing flow-based approach. Our network is also designed with a recurrent propagation stream to encourage temporal consistency in video results. Experiments on video object removal demonstrate that our method inpaints the holes with globally and locally coherent contents.
Natural Product Target Network Reveals Potential for Cancer Combination Therapies

A body of research demonstrates examples of in vitro and in vivo synergy between natural products and anti-neoplastic drugs for some cancers. However, the underlying biological mechanisms are still elusive. To better understand biological entities targeted by natural products and therefore provide rational evidence for future novel combination therapies for cancer treatment, we assess the targetable space of natural products using public domain compound-target information. When considering pathways from the Reactome database targeted by natural products, we found an increase in coverage of 61% (725 pathways), relative to pathways covered by FDA approved cancer drugs collected in the Cancer Targetome, a resource for evidence-based drug-target interactions. Not only is the coverage of pathways targeted by compounds increased when we include natural products, but coverage of targets within those pathways is also increased. Furthermore, we examined the distribution of cancer driver genes across pathways to assess relevance of natural products to critical cancer therapeutic space. We found 24 pathways enriched for cancer drivers that had no available cancer drug interactions at a potentially clinically relevant binding affinity threshold of < 100nM that had at least one natural product interaction at that same binding threshold. Assessment of network context highlighted the fact that natural products show target family groupings both distinct from and in common with cancer drugs, strengthening the complementary potential for natural products in the cancer therapeutic space. In conclusion, our study provides a foundation for developing novel cancer treatment with the combination of drugs and natural products.
Topic-Enhanced Memory Networks for Personalised Point-of-Interest Recommendation

Point-of-Interest (POI) recommender systems play a vital role in people's lives by recommending unexplored POIs to users and have drawn extensive attention from both academia and industry. Despite their value, however, they still suffer from the challenges of capturing complicated user preferences and fine-grained user-POI relationship for spatio-temporal sensitive POI recommendation. Existing recommendation algorithms, including both shallow and deep approaches, usually embed the visiting records of a user into a single latent vector to model user preferences: this has limited power of representation and interpretability. In this paper, we propose a novel topic-enhanced memory network (TEMN), a deep architecture to integrate the topic model and memory network capitalising on the strengths of both the global structure of latent patterns and local neighbourhood-based features in a nonlinear fashion. We further incorporate a geographical module to exploit user-specific spatial preference and POI-specific spatial influence to enhance recommendations. The proposed unified hybrid model is widely applicable to various POI recommendation scenarios. Extensive experiments on real-world WeChat datasets demonstrate its effectiveness (improvement ratio of 3.25% and 29.95% for context-aware and sequential recommendation, respectively). Also, qualitative analysis of the attention weights and topic modeling provides insight into the model's recommendation process and results.
Fallout: Reading Kernel Writes From User Space

Recently, out-of-order execution, an important performance optimization in modern high-end processors, has been revealed to pose a significant security threat, allowing information leaks across security domains. In particular, the Meltdown attack leaks information from the operating system kernel to user space, completely eroding the security of the system. To address this and similar attacks, without incurring the performance costs of software countermeasures, Intel includes hardware-based defenses in its recent Coffee Lake R processors. In this work, we show that the recent hardware defenses are not sufficient. Specifically, we present Fallout, a new transient execution attack that leaks information from a previously unexplored microarchitectural component called the store buffer. We show how unprivileged user processes can exploit Fallout to reconstruct privileged information recently written by the kernel. We further show how Fallout can be used to bypass kernel address space randomization. Finally, we identify and explore microcode assists as a hitherto ignored cause of transient execution. Fallout affects all processor generations we have tested. However, we notice a worrying regression, where the newer Coffee Lake R processors are more vulnerable to Fallout than older generations.