Miracle-dz/UniFAR-FTUs huggingface dataset:
Burning mouth syndrome (stomatodynia) sensile to duloxetine-a case report

Introduction: Burning mouth syndrome (BMS) is a chronic, idiopathic, intraoral mucosal pain condition in the absence of specific oral lesions and systemic disease. Among evidence-based pharmacological treatments for this disorder, topical and systemic clonazepam, levosulpiride, selective serotonin reuptake inhibitors have been used with partial results. Case: We report a case of a 65-year-old healthy woman with a 3year history of oral burning. Clinical and laboratory evaluations allowed us to make a diagnosis of burning mouth syndrome. She was treated with duloxetine (DLX) (60 mg PO qd), a selective serotonin, and norepinephrine reuptake inhibitor, obtaining a complete remission of symptoms, evaluated via standardized clinical rating scales (BPRS), and an improvement of her quality of life and level of functioning. Discussion: The pathogenesis of BMS still remains unclear. Recently, it has been suggested an underlying neuropathic mechanism, demonstrating a dysfunction in the trigeminal nociceptive pathways at peripheral and/or central nervous system level. The rationale behind the administration of duloxetine resides in its central mechanism of action, and analgesic effects previously demonstrated in diabetic peripheral neuropathy, and fibromyalgia. Also, it has been shown to reduce painful physical symptoms associated with depression. Conclusion: We hypothesize that duloxetine might represent a useful, effective, and additional therapeutic option in the treatment of BMS.
Distinct short-term plasticity at two excitatory synapses in the hippocampus

A single mossy fiber input contains several release sites and is located on the proximal portion of the apical dendrite of CA3 neurons. It is, therefore, well suited to exert a strong influence on pyramidal cell excitability. Ac- cordingly, the mossy fiber synapse has been referred to as a detonatororteachersynapseinautoassociativenetworkmod- els of the hippocampus. The very low firing rates of granule cells (Jung, M. W. & McNaughton, B. L. (1993)Hippocampus 3, 165-182), which give rise to the mossy fibers, raise the questionofhowthemossyfibersynapsetemporallyintegrates synaptic activity. We have therefore addressed the frequency dependence of mossy fiber transmission and compared it to associationalycommissural synapses in the CA3 region of the hippocampus. Paired pulse facilitation had a similar time course, but was 2-fold greater for mossy fiber synapses. Frequency facilitation, during which repetitive stimulation causes a reversible growth in synaptic transmission, was markedly different at the two synapses. At associationaly commissural synapses facilitation occurred only at frequen- cies greater than once every 10 s and reached a magnitude of about 125% of control. At mossy fiber synapses, facilitation occurred at frequencies as low as once every 40 s and reached a magnitude of 6-fold. Frequency facilitation was dependent on a rise in intraterminal Ca 21 and activation of Ca 21 ycal- modulin-dependent kinase II, and was greatly reduced at synapses expressing mossy fiber long-term potentiation. These results indicate that the mossy fiber synapse is able to integrate granule cell spiking activity over a broad range of frequencies, and this dynamic range is substantially reduced by long-term potentiation.
Interruptions of nursing activities: contributions to patient and professional safety

Results: We observed 2,295 activities, most of them were classifi ed as indirect patient care (38.6%) and direct patient care (22.5%). Seven hundred and nineteen (31.3%) interrupted activities were identifi ed, with mean of 1.6 interruptions in the same activity, thus totaling 1,180 interruptions. There was greater number of interruptions during the indirect care (44.7%), and their main sources were the nursing (43.3%), and the physicians and residents (16.5%) staffs. The number of individuals in the units (staff and family/visitors), the proportion of patients under high-dependency, the number of healthcare and allied professionals infl uenced the number of interruptions.
A new marsh-dwelling species of Eleutherodactylus from Haiti (Anura : Leptodactylidae)

A new species of leptodactylid frog (Eleutherodactylus) is described from a coastal mangrove marsh at the distal end of the Tiburon Peninsula in Haiti. It is a member of the bakeri series of the subgenus Euhyas, and is distinguished by its high-frequency call and unique reticulate skin texture. Direct development and thus, the ability to lay eggs on land far from any water source, almost certainly played a large part in the enor- mous radiation of the leptodactylid frog genus Eleutherodactylus (approx. 500 spp.). The rela- tively few species that have reinvaded aquatic niches usually occur along small upland streams; none is known to regularly inhabit coastal swamps or marshes with standing water. Hence, we were surprised to encounter a new species of Eleutherodactylus in a coastal marsh dominat- ed by red mangrove (Rhizophora mangle) at the distal (western) end of the Tiburon Peninsula of Haiti. MATERIALS AND METHODS The following abbreviations are used: EL, eye length; EN eye-naris distance; FTW, fingertip (III) width; HL, head length; HW, head width; kHz, kilohertz; SHL, shank length; SVL, snout- vent length; THL, thigh length; and TYM, tym- panum width. Museum abbreviations follow standardized usage (Copeia 1985:802-832). Measurements were taken with digital calipers (0.01 mm accuracy) and live weights were taken with a Pesola spring scale (0.01 g accuracy). Calls were recorded with a Sony TCM 5000 recorder and Electrovoice 635A microphone. Call anal- yses were made with a Digital Sona-Graph 7800 and Kay Sona-Graph 7900 printer. Terminology for call parameters follows Duellman and Trueb (1986).
INCIDENCE OF PASTEURELLA SPECIES FROM NEWLY BORN PNEUMONIC CALVES IN KAFR EL-SHEIKH GOVERNORATE

Samples were collected from pneumonic calves from both sex under one month in Kafrelsheikh Governorate (150 nasal swabs from living calves and 20 pneumonic calves lung tissues recently dead calves). Samples were examined for the presence of Mannheimia multocida and M. haemolytica. Isolation, biochemical and serologic al identification revealed that a total of 124 non-repeated bacterial isolates were recovered from 170 pneumonic calves samples. Isolation revealed that a total of 47 (37.9%) P. multocida and 38 (30.6%) of M. haemolytica isolates were recovered.
Harmonic spectra of BLDC motor supplied by a solar PV multilevel inverter

The multilevel inverters have been used especially in renewable energy aspects in order to assess total harmonic distortion (THD). THD is considered to produce a good quality of current signal of BLDC motor drive. In this paper, a solar PV inveter fed brushless DC (BLDC) motor drive is discussed considering two topologies of three phase multilevel inverters. These topologies are flying capacitor and clamped diode inverters. The inverter efficiency and output power have an effectiveness on THD values. A boost dc to dc converter using incremental conductance maximum power point tracking (INC-MPPT) is implemented with a solar PV. The mathematical model of the proposed systems ares tudied via simulation using Matlab/Simulink. The simulation results of a BLDC motor based on two multilevel inverters are compared with each other considering the THD and the utilization of the dc-bus voltage, the comparition verified that the clamped diode inverter has a better harmonic spectra.still the overshoot is a little bit high in the two types of inverter that are proposed.
Are Ethical Funds More Resistant to Crisis than Conventional funds?

The development of faith-based funds and socially r esponsible funds challenges modern portfolio theory as some investors move away from t he risk-return paradigm by constraining their portfolios to “ethical” investments. This typ e of investment attempts to balance the regard for morality of a firm’s activities and the regard for return on investment. Such ethical investors will shun companies whose behaviours they condemn, or focus on companies that represent values in which they believe. Hence, in addition to maximizing return and/or minimizing risk, they integrate non-pecuniary preferences in their i nvestment decisions (Gillet 2009). Ethical investments include a wide range of mutual funds, u nit trusts and equity indices that can be classified into socially responsible investment (fo llowing so-called Environmental, Social and Governance criteria) and faith-based investment (fo llowing for instance Christian or Islamic principles). Socially responsible and Islamic funds have grown considerably in the last 20 years, both in volume and value (Hoepner, Rammal, & Rezec 2011; Renneboog, Ter Horst, & Zhang 2012). On one side, the characteristics and p erformance of socially responsible funds and indices has been subject to many empirical stud ies which offer conflicting evidence (Leite & Cortez 2014; Renneboog, Ter Horst, & Zhang 2008). On the other side, the Islamic financial system survived the 2007-08 financial crisis, but w as it because of its moral and ethics standards or because the financial sector equities ar excluded of the Islamic oriented portfolios, as suggested by Jouini & Pastré (2009) ?
Carcinome épidermoïde de la vulve chez une patiente infectée par le VIH-1 en échec de traitement antirétroviral de première ligne

Le cancer de la vulve est une affection rarement rapportée dans la littérature. Chez la femme jeune, il est le plus souvent lié à l´infection par le papillomavirus humain (HPV) alors que chez les femmes ménopausées, chez qui ce cancer est plus fréquent, il serait lié à la carence œstrogénique. En outre, l´infection à VIH augmente le risque de survenue chez les femmes séropositives de néoplasies vulvaires du fait de la prévalence élevée de l´infection à HPV chez elles. Ainsi devant toute lésion suspecte de la vulve, une biopsie suivie d´un examen anatomo-pathologique devra être réalisée afin de poser le diagnostic. Nous rapportons le cas d´un carcinome épidermoïde de la vulve chez une patiente séropositive au VIH-1 en échec de traitement antirétroviral (ARV) de première ligne.
Epidemiology, Clinical Aspects, Laboratory Diagnosis and Treatment of Rickettsial Diseases in the Mediterranean Area During COVID-19 Pandemic: A Review of the Literature

The purpose of the present review is to give an update regarding the classification, epidemiology, clinical manifestation, diagnoses, and treatment of the Rickettsial diseases present in the Mediterranean area. We performed a comprehensive search, through electronic databases (Pubmed – MEDLINE) and search engines (Google Scholar), of peer-reviewed publications (articles, reviews, and books). The availability of new diagnostic tools, including Polymerase Chain Reaction and nucleotide sequencing has significantly modified the classification of intracellular bacteria, including the order Rickettsiales with more and more new Rickettsia species recognized as human pathogens. Furthermore, emerging Rickettsia species have been found in several countries and are often associated with unique clinical pictures that may challenge the physician in the early detection of the diseases. Rickettsial infections include a wide spectrum of clinical presentations ranging from a benign to a potentially life treating disease that requires prompt recognition and proper management. Recently, due to the spread of SARS-CoV-2 infection, the differential diagnosis with COVID-19 is of crucial importance. The correct understanding of the clinical features, diagnostic tools, and proper treatment can assist clinicians in the management of Rickettsioses in the Mediterranean area.
Experimental induction of blunt chest trauma in mice: A modified approach with evaluation in dummies and cadavers

Experimental chest trauma or blunt thoracic trauma using a blast wave mechanism is well established in animal models. The aim of the present study was to establish a complementary, murine experimental chest trauma model precisely defined by physical data and calculations. For this purpose, a device was developed using a dropped weight and physical properties, including velocity, energy and impact, were calculated. The device allowed for the maximum depth of impression to be measured. The device was first tested using blocks of modelling clay and was then applied to mouse cadavers. X-ray and dissection were performed to check for bone fractures and organ injuries following blunt chest traumas of increasing impact. Lesions and hemorrhages were observed in mouse cadavers which sustained a force equivalent to the energy of ~1 J.
Early experience with permanent pacemaker implantation at a tertiary hospital in Nigeria

Introduction artificial pacemakers generate electrical impulses and regulate the heart&acutes conduction system. They are often used to treat individuals with bradycardia. Permanent pacemaker implantation is a lifesaving procedure especially in patients with symptomatic bradyarrhythmias. The objectives was to evaluate the clinical attributes and outcomes of permanent pacemaker implantation in Ile-ife, Nigeria. Methods we retrospectively reviewed medical records of 22 patients who had pacemaker implantation from January 2015 to December 2019. Patient´s demographics, clinical presentation, diagnosis, comorbidities, type of device, complications and long-term follow up were studied. Results sixteen males (72.7%) and 6 females (27.3%) were recruited into the study with ages ranging between 54 and 84 years and a mean of 70.3 +8.7 years. The commonest symptom was easy fatigability (45.5%) followed by syncope (31.8%). The main indication for permanent pacemaker implantation was complete heart block (86.4%). Seventeen (77.3%) patients had hypertension as the comorbidity present at diagnosis. Single chamber (VVIR) pacemaker was implanted in 13(59.1%) patients while dual chamber (DDDR) was implanted in 9(40.9%) patients. Hematoma, pneumothorax and acute lead dislodgement were the complications observed in 3 patients. There was no statistical significance between the type of device implanted and the occurrence of complications, p-value 0. 186. There was no mortality and 15 patients (68.2%) are currently attending regular 6 monthly follow-up. Conclusion complete heart block is the most common indication for permanent pacemaker implantation and the procedure is safe with minimal complications and satisfactory outcomes.
Influence of rising sea temperature on commercial bivalve species of the US Atlantic coast

Two of the most important commercial molluscan fisheries along the U.S. Atlantic coast are for ocean quahogs Arctica islandica and Atlantic surfclams Spisula solidissima. Both species are common north of Cape Hatteras, North Carolina, their southern boundary. This paper describes how historical and possible future changes in ocean temperature have and could impact these species and their fisheries. Ocean quahogs are typically found in cold water and population genetic data from the mitochondrial cytochrome b gene indicate that the species range shifted in response to environmental warming and cooling since the last ice age, 10,000 years ago. Rising sea temperature in the future would likely cause an offshore and northward contraction of the ocean quahog's range. Atlantic surfclams are not as sensitive to high temperature as ocean quahogs. However, increased sea temperatures off Delaware and Virginia may be stressful because Atlantic surfclam populations in this region already have relatively low growth rates and meat weights associated with high intraspecific density.
Diverse Diets with Consistent Core Microbiome in Wild Bee Pollen Provisions

Bees collect pollen from flowers for their offspring, and by doing so contribute critical pollination services for our crops and ecosystems. Unlike many managed bee species, wild bees are thought to obtain much of their microbiome from the environment. However, we know surprisingly little about what plant species bees visit and the microbes associated with the collected pollen. Here, we addressed the hypothesis that the pollen and microbial components of bee diets would change across the range of the bee, by amplicon sequencing pollen provisions of a widespread small carpenter bee, Ceratina calcarata, across three populations. Ceratina calcarata was found to use a diversity of floral resources across its range, but the bacterial genera associated with pollen provisions were very consistent. Acinetobacter, Erwinia, Lactobacillus, Sodalis, Sphingomonas and Wolbachia were among the top ten bacterial genera across all sites. Ceratina calcarata uses both raspberry (Rubus) and sumac (Rhus) stems as nesting substrates, however nests within these plants showed no preference for host plant pollen. Significant correlations in plant and bacterial co-occurrence differed between sites, indicating that many of the most common bacterial genera have either regional or transitory floral associations. This range-wide study suggests microbes present in brood provisions are conserved within a bee species, rather than mediated by climate or pollen composition. Moving forward, this has important implications for how these core bacteria affect larval health and whether these functions vary across space and diet. These data increase our understanding of how pollinators interact with and adjust to their changing environment.
Fear of Rejection: Scale Development and Validation

The present article tries to define the construct of fear of rejection and describes the development of the fear of rejection scale. Fear of rejection can be defined as an irrational fear of being rejected before making any actual attempt. It may be the result of continuous rejection in the past. Fear of rejection can hamper the daily functioning of the person and hence affecting the overall physical and psychological health. It is a grave social problem getting its roots deepening in the lives of adolescents and young adults to be dealt with. The scale so developed was administered to 400 adolescents to determine its factor structure and the data collected were subjected to factor analysis by using SPSS 20. Principal Component Analysis (PCA) was carried out and varimax rotation technique was used for rotating the factors. PCA yielded simple three-factor structure. The three factors accounted for 52.38% of the variance. The present scale can be used for further research and for development programs in school/universities and organizations.
Efeito do extrato etanólico de sementes de Annona mucosa no desenvolvimento e comportamento alimentar de Spodoptera frugiperda

In Brazil, the fall armyworm Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is an important pest of maize and other crops including horticultural crops, soybean, rice, and cotton. Botanical insecticides are an interesting option for S. frugiperda management especially in organic production systems, and annonaceous derivatives have been considered a promising source of them. In light of this potential, we investigated the antifeedant and growth inhibitory effects of ethanolic extract from Annona mucosa seeds — ESAM (Annonaceae) against S. frugiperda using dietary exposure bioassays. ESAM decreased larval and pupal viabilities and also the pupal weight as well as increased the larval phase duration of S. frugiperda. Moreover, ESAM also caused an increase in the proportion of pupae and adults with morphological changes. However, ESAM did not cause antifeedant effect for 4-instar S. frugiperda larvae, though it decreased consumption throughout the time (post-ingestive toxicity).
Overexpression of Spondin-2 Is Associated with Recurrence-Free Survival in Patients with Localized Clear Cell Renal Cell Carcinoma

Background The spondin-2 (SPON2) gene is overexpressed in multiple malignant tumors and may promote tumor aggressiveness. However, its expression profile and functional roles in clear cell renal cell carcinoma (ccRCC) are still unclear. Methods SPON2 expression in ccRCC was evaluated using expression data from TCGA and GEO databases, then confirmed by local patient population (94 patients). The clinical significance of SPON2 expression was evaluated. Downregulation of SPON2 was performed using small-interfering RNA (siRNA). The effects of SPON2 silencing on cell proliferation, apoptosis, invasion, and migration in vitro were investigated. Results SPON2 was overexpressed in the majority of the ccRCC at both mRNA and protein levels. SPON2 expression was significantly correlated with stage, grade, and recurrence (all P < 0.05) in patients with localized ccRCC. The receiver operating characteristic (ROC) curve showed that SPON2 expression could serve as a predictor of recurrence. SPON2 expression was significantly associated with recurrence-free survival (RFS) in patients with localized ccRCC. Knocking down SPON2 resulted in suppressed cell invasion and migration in vitro. Conclusion SPON2 expression might function as a prognostic biomarker in patients with localized ccRCC.
A Depth of Deep Learning for Big Data and its Applications

:- Although Machine Learning (ML) has become synonymous for Artificial Intelligence (AI); recently, Deep Learning (DL) is being used in place of machine learning persistently. While machine learning is busy in supervised and unsupervised methods, deep learning continues its motivation for replicating the human nervous system by incorporating advanced types of Neural Networks (NN). If we apply Deep Learning to Big Data, we can ﬁnd unknown and useful patterns that were impossible so far. Deep Learning is applied in self driving cars, visual recognition, healthcare, transportation etc. Nowadays, companies have started to realize the importance of data availability in large amounts in order to make the correct decision and support their strategies. Big Data means extremely huge large data sets, which is heterogeneous whose characteristics (large volume, different forms, speed of processing), analyzed to ﬁnd the patterns, trends. This paper provides an introductory tutorial to the domain of deep learning for Big Data with its history, evolution, and introduction to some of the sophisticated neural networks such as Deep belief network , Convolutional Neural Network (CNN) and Recurrent Neural Network (RNN)
EVALUATION AND SCRUBBING OF BIOGAS GENERATION FROM AGRICULTURAL WASTES AND WATER HYACINTH

This study aimed to characterize anaerobic batch biodegradation of five co-digested mixtures in terms of methane yield and energy production as follows: Mixture 1 (potato waste + sugar beet leaves), mixture 2 (cattle dung), mixture 3 (water hyacinth + cattle dung), mixture 4 (rice straw + cattle dung + poultry droppings) and mixture 5 (bagasse + cattle dung). Effects of stirring, dry oxidation and water scrubbing processes on the biogas quality were also examined. The peak values of gas generation reached up to 0.344 and 0.476 L/L/day for control and handle stirring in case of mixture 5. The results showed significant differences in biogas production between control and stirring for different mixtures. The biogas generation increased by stirring with 60.33% compared to control. The highest values of CH4 were 75, 69.7 and 68.6% for mixtures 1, 5 and 3, respectively. The average CO2 ranged from 31.65 to 37.46%, while H2S contents ranged from 2017.6 to 2622.4 ppm. Average removal efficiencies of CO2 and H2S reached up to 94.84 and 97.2%, respectively. Upgrading biogas enriched it with methane content up to 95.71% and increased its calorific value up to 31.28 MJ/m. It could be concluded that, the mixing and stirring as well as dry oxidation and water scrubbing processes have an important role and efficacy in the biogas production quantity and quality. Recycling of wastes and biogas production requires strong governmental support to be successful.