Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of the effects of three cryoprotectants on the cryopreservation of mouse subcutaneous tissue under different conditions

The subcutaneous tissue of animals contains different cell types, and different cells have different requirements for cryopreservation. This establishes obstacles that need to be overcome in the clinical application of tissue preservation. In the present study, the effects of different freezing rates and various concentrations of cryoprotectants on the cryopreservation of subcutaneous tissue of mice were compared, and these results provided basic research data that can be used to explore the optimal cryopreservation method for tissue. The effects of three cryoprotectants, dimethyl sulfoxide, glycerinum and 1,2-propanediol, and their concentrations on the cryopreservation of subcutaneous tissue of mice were compared with slow and rapid freezing rates. The results revealed that under various cryopreservation conditions, the percentage of fibroblasts that grow from the tissue following slow cryopreservation (19.8%) was significantly higher than that following rapid freezing (6.7%) at osmotic equilibrium for 10-20 min (P<0.05). After 19 days of culture, under the conditions of slow freezing, with 10, 20 and 30% glycerinum as a cryoprotectant, respectively, fibroblasts grew from 26.0, 16.7 and 16.7% of the tissues, respectively. No fibroblasts were indicated in the tissue mass cultured in any other tissue blocks treated with cryopreservation solutions. Under the condition of rapid freezing, fibroblasts grew from 6.7 and 6.7% tissue blocks of 20% DMSO and 10% glycerinum, respectively, following 19 days of culture. No fibroblasts were identified in the tissue mass cultured in the other tissue blocks treated with cryopreservation solutions, and no fibroblasts were identified in the tissue blocks without osmotic balance before freezing.
Analysis in Integer and Fractional Dimensions: Index

Preface 1. A prologue: mostly historical 2. Three classical inequalities 3. A fourth inequality 4. Elementary properties of the Frechet variation - an introduction to tensor products 5. The Grothendieck factorization theorem 6. An introduction to multidimensional measure theory 7. An introduction to harmonic analysis 8. Multilinear extensions of the Grothendieck inequality 9. Product Frechet measures 10. Brownian motion and the Wiener process 11. Integrator 12. A '3/2n- dimensional' Cartesian product 13. Fractional Cartesian products and combinatorial dimension 14. The last chapter: leads and loose ends.
Evolution of entrepreneurial motivation: the transition from economic necessity to entrepreneurship

Most of the small business operators in Tanzania. as well as other developing countries started business as a result of economic necessity. It therefore becomes of interest to know the extent to which they are entrepreneurial in the sense of wanting to develop substantial enterprises and whether this behaviour changes over time. This study sought to explain the process through which this evolution occurs. Five cases of Tanzanian owner-managers who reported to have started business activity due to economic necessity were analysed. using the grounded theory approach. the constant comparative method and a replication strategy. The results suggest that the owner-manager who starts a business because of economic necessity is uncommitted to both the business and the entrepreneurial career. He is merely hanging on an activity. For this reason. his/her future orientation is qUite passive and therefore growth motivation is non-existent or extremely low. In the occasions where he/she evolves into a serious entrepreneur desiring and pro~ctively seeking substantial growth. he/she must go through a number of sequential stages. He/she must first stabilise his personal life. acquire commitment to the business. stabilise the business and acquire commitment to the career. A number offactors influence the direction and pace of this evolution. A favourable external environment. resources that are useful only in the context of the firm and interest in the activity Enterprise development initiatives in developing countries should also aim at enhancing growth motivation and in particular the process of evolution from economic necessity to entrepreneurship. This can help minimise defoult rates when lending to micro and small enterprise operators. This knowledge can also be used for sensitising ownermanagers in the process through which they are evolving and thereby accelerating it.
Intelligent Condition-Based Monitoring Techniques for Bearing Fault Diagnosis

In recent years, intelligent condition-based monitoring of rotary machinery systems has become a major research focus of machine fault diagnosis. In condition-based monitoring, it is challenging to form a large-scale well-annotated dataset due to the expense of data acquisition and costly annotation. The generated data have a large number of redundant features which degraded the performance of the machine learning models. To overcome this, we have utilized the advantages of minimum redundancy maximum relevance (mRMR) and transfer learning with a deep learning model. In this work, mRMR is combined with deep learning and deep transfer learning framework to improve the fault diagnostics performance in terms of accuracy and computational complexity. The mRMR reduces the redundant information from data and increases the deep learning performance, whereas transfer learning, reduces a large amount of data dependency for training the model. In the proposed work, two frameworks, i.e., mRMR with deep learning and mRMR with deep transfer learning, have explored and validated on CWRU and IMS rolling element bearings datasets. The analysis shows that the proposed frameworks can obtain better diagnostic accuracy compared to existing methods and can handle the data with a large number of features more quickly.
Assessment of Children's Social Skills: Recent Developments, Best Practices, and New Directions.

This article provides an overview of some of the recent developments in assessing social skills of children and youth, as well as a discussion of "best practices" in conducting assessment and linking assessment to effective intervention. Naturalistic behavioral observation and behavior rating scales are proposed as the 2 assessment methods that should be considered primary or "first-line" choices for social skills assessment. A review of some specific tools that have been developed within these 2 assessment methods is provided. Interviewing and sociometric techniques, although not necessarily primary methods of assessment for children's social skills, sometimes may be an important part of an assessment design, or "second-line" choices. Projective-expressive techniques or objective self-report instruments for assessing children's social skills sometimes may help illuminate the overall assessment results but should never be used as primary assessment methods for social skills; thus, these methods are consid.
A Influência do Eixo Visuo-Podal na Regulação do Equilíbrio Morfoestático em Idosos

Introdução. A boa postura é o estado de equilíbrio musculoesquelético que protege as estruturas de sustentação do corpo, podendo diminuir a possibilidade de quedas e suas consequências. Queda é o deslocamento não intencional do corpo com incapacidade de correção em tempo hábil, sua etiologia é bastante complexa e o sistema sensorial proprioceptivo tem apresentado fortes evidências como fator causal. Embora essas correlações tenham sido negligenciadas pela maioria dos profissionais de saúde, a correção do sistema sensorial proprioceptivo, através de seus principais elementos: visual (convergência) e podal (valgo/varo), parece fundamental para a obtenção do equilíbrio postural. Objetivo. Discutir a influência visual e podal no equilíbrio morfoestático em idosos, bem como a prevenção de eventuais quedas. Método. Foi realizada uma busca nas bases de dados: Index Medicus; Biological Abstracts; Pub Med; Bireme; PEDro e Lilacs e selecionados os artigos pertinentes ao tema. Discussão. A Posturologia Clínica visa resgatar o controle postural com estímulos mantidos em tempo hábil para promover mudanças no sistema sensorial e esquema corporal (neuroplasticidade), prevenindo quedas pela funcionalização do alinhamento e da estabilidade. Conclusão. As quedas ocorrem independente da idade e a regulação do eixo visuo-podal parece resgatar o equilíbrio postural e prevenir as quedas em idosos.
Electronic transitions with quantum trajectories. II

The quantum trajectory method (QTM) is applied to nonadiabatic electronic transitions. Equations of motion in a Lagrangian framework are derived for the probability density, velocity, position, and action functions for a discretized wave packet moving along coupled potential energy surfaces. In solving these equations of motion, we obtain agreement with exact quantum results computed by solving the time-dependent Schrodinger equation on a space-fixed grid. On each of the coupled potential energy surfaces, the dynamics of the trajectories is fully quantum mechanical, i.e., there are no “surface–hopping transitions. ” We present a detailed analysis of the QTM results including density changes, complex oscillations of the wave functions, phase space analysis, and a detailed discussion of the forces that contribute to the evolution the trajectories.
Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease

It is often difficult to assess small bowel recovery in adults with coeliac disease on a gluten-free diet (GFD). This prospective study compares changes in intestinal permeability with changes in intestinal biopsy at various intervals after commencing a GFD. Intestinal permeability was measured by lactulose/rhamnose absorption from 1 week to 24 months after commencing a GFD. Intestinal morphometry was measured by villus area, crypt length and mitotic count per crypt at diagnosis and after commencing a GFD. Median intestinal permeability values decreased from 0.47 (n = 35) at diagnosis to 0.25 (n = 17) after 1 week and to 0.16 (n = 18) after 2 months of a GFD. Rhamnose absorption improved significantly at an early stage, from 6.6% (untreated) to 15.4% at 3 months of a GFD, whereas the decrease in lactulose permeation took longer: from 3.4% (untreated) to 0.8% after 12 months of a GFD. Mean villus area (n = 29) was reduced to 16% of control values at diagnosis, and improved to a maximum of 48% after 6 months on a GFD, but did not change thereafter. Mean crypt length and mitotic count per crypt were increased by 222% and 356% respectively at diagnosis, and these parameters remained elevated at 172% and 216% above control values after 6 months of a GFD. We conclude that intestinal permeability improves within 2 months after starting a GFD, but that measurable intestinal biopsy improvement requires ingestion of a GFD for at least 3-6 months, and even then remains incomplete.
Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture

Historically, two strategies have been used to dissect the insulin signal transduction pathway. One was to start at the insulin receptor and work down the signal transduction pathway from the plasma membrane. The other was to select a physiological action of insulin, namely the mechanism by which insulin stimulates glycogen synthesis, and then work backwards towards the receptor. The hope was that eventually the groups working down from the top of the insulin signalling pathway would meet up with those working upwards from the bottom of the pathway. This has now happened, and in this lecture I will describe the recent advances that have linked the research from both ends of the insulin signal transduction pathway. I will also discuss how these findings have enabled pharmaceutical companies to embark on novel programmes to develop improved therapies for the treatment of diabetes in the future.
Association of killer cell immunoglobulin-like receptor gene polymorphisms with Graves′ disease

Ninety-six Graves′ disease (GD) patients and 96 randomly matched healthy controls were enrolled to detect the genotypes of the killer cell immunoglobulin-like receptor (KIR, 11 loci) by PCR-SSP. The results indicated that the gene frequency of KIR2DS4 was significantly lower in GD group compared with that of the control group (0.500 vs 0.856, P0.01, RR=0.58), suggesting a negative relationship between pathogenesis of Graves′ disease and KIR2DS4 gene.
Uterotrophic effect of a saturated fatty acid 17‐ester of estradiol‐17β administered orally to juvenile rats Note

In comparison to estradiol‐17β, the naturally synthesized estradiol‐17β‐17‐fatty acid esters are potent estrogens when administered subcutaneously. A lipophilic character of estradiol‐17‐esters could partially protect them from metabolic inactivation. In order to compare their relative estrogenic potency when administered orally, the uterotrophic response to different dosages (0, 2.5, 25, 250 and 2500 nmol/kg BW/day) of estradiol‐17β and estradiol‐17β‐17‐stearate was assessed in juvenile Sprague‐Dawley female rats. Estrogens were administered by oral gavage once a day for 6 days. On the 7th day uterus and vagina were dissected, weighed, and examined microscopically. At 2.5 and 25 nmol/kg BW/day, no difference was detected in the uterus weight compared to control animals which received the vehicle alone (corn oil). At 250 nmol/kg BW/day, the uterotrophic response was maximal in estradiol‐17β‐17‐stearate‐treated animals (×2.40–2.70), whereas it was moderate in estradiol‐17β‐treated rats (×1.86) at the same dosage. This differential weight gain effect of estradiol‐17β‐17‐stearate was correlated with typical microscopic changes in uterus and vagina. The results are in favour of a stronger estrogenic effect of orally given lipoidal estrogens compared to estradiol‐17β. This could be explained by a slower but sustained absorption of estradiol‐17β released from estradiol‐17β‐17‐stearate by esterases and/or by a facilitated transfer of esters in the lymphatic circulation.
From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters Note

For three decades, we have known that estrogens alter the development of the mammalian reproductive system in predictable ways. In mice exposed prenatally to diethylstilbestrol (DES) or other estrogens, the male offspring exhibit structural malformations including cryptorchidism, epididymal cysts and retained Mullerian ducts. The estrogen‐associated alterations in the genital tract phenotype can be usefully considered as a model called Developmental Estrogenization Syndrome. While estrogen treatment during critical periods of morphogenesis of the male reproductive system has been associated with these changes, the mechanisms at the molecular level are still being discovered. Parallel findings on the hormones involved in Mullerian duct regression and testicular descent have helped guide research on the mechanisms of developmental estrogenization of the male. Cellular localization of molecular signals associated with key steps in genital tract development, use of mice with gene disruption, and knowledge of the mechanisms underlying persistent changes in gene expression are beginning to provide a blue print for both the physiological role and pathological effects of estrogens in reproductive tract development. Since many of the same biological principles underlie genital tract morphogenesis in mammals, one may expect some of the same changes in males of other species exposed to estrogen during the appropriate developmental periods.
The Influence of heat stress on semen quality and serum biochemical indexon beef breeding bull

Limousin bulls and 5 Charolais bulls were used to examine the influences of heat stress on semen quality and blood biochemical parameters. The results showed that: (1) In heat stress period, semen motility, percentage of motile sperm and percentage intact acrosome were at the lowest level ( P 0 01) (2) Compared with non heat stress period, the mean concentrations of blood serum testosterone (4 15 pg/mL), T 3 (1 11 pg/mL), LH (48.12 pg/mL), cortisol (4 89 pg/mL) were at the lowest level ( P 0 01) (3) Compared with spring, autumn and winter, the blood sugar was decreased by 38 3%? 12 1% and 19 9% ( P 0 01) (4) During heat stress period, the serum sodium? potassium? calcium and magnesium were at the lowest level compared with non heat stress period (5) In summer, the serum GPT(33 55 U/L) and GOT(75 39 U/L) were at the highest level, but serum CK(47 92 U/L) were on the contrary.
Change in size and abundance of the yeast-like endosymbiote during the interaction between brown planthopper,Nilaparvata lugens(Stl),and resistant-variety rice

There are mass of yeast-like endosymbiote(YLES) in abdomen fat body of brown planthopper(BPH) Nilaparvata lugens(Stl),which plays vital physiological and nutritional roles on the BPH.In this study,the effects of the interaction between BPH and BPH-resistant rice(cv.IR26 with Bph1 and cv.IR36 with bph2 vs.the susceptible cv.TN1) on size and abundance of YLES were studied by the cryostat microtome method in combination with the photomicrography and by using the haemacytometer.Compared with the length and width of YLES in BPH reared on susceptible-variety rice TN1,the length of YLES decreased with 23.2%-24.4% and 18.0%-32.7%,the width of YLES decreased with 24.4%-28.8% and 8.6%-30.6%,respectively,when BPH fed on IR26 and IR36 for three successive generations.And the abundance of YLES also significantly decreased when BPH fed on IR26 and IR36 relative to TN1.Moreover,there was the lowest abundance of YLES after BPH fed on IR26 for two generations,and the abundance of YLES increased after the third generation.It is presumed that the interaction between BPH and BPH-resistant rice may result in smaller YLES and less abundance of YLES.
From Sugar to Revolution

In this original and provocative study, Myriam Chancy reads the catastrophic history of the Caribbean in the narrative and visual fictions of a number of remarkable women artists, disclosing hitherto uncharted maps of time and voice and remembrance. A work of studied insight, engaged criticism, and graceful sentences, it will alter not only the frames in which Haiti, Cuba, and the Dominican Republic are represented, but the very conditions for a gendered and transnational inquiry into the Caribbean present. – David Scott, Columbia University; Editor,
Phylogeography of the Marine Gastropod Reticunassa festiva Complex (Nassariidae) in the Coast of China

ABSTRACT Revealing cryptic biodiversity and understanding their evolutionary histories is important to predict how climate change promoted diversification. The marine gastropod Reticunassa festiva is a common species distributed along the coast of China Seas and possesses cryptic diversity. In the present study, the phylogeographic pattern of R. festiva is investigated to test the potential mechanism that drove its diversification in China coastal regions using the mitochondrial cytochrome oxidase subunit I (COI) and nuclear 28S rDNA sequences. Three highly divergent COI clades (Clades A, B, and C) with considerable differences in genetic distances, haplotype diversity, and nucleotide diversity among each other were identified. The estimated divergence time between the two dominant clades (Clades A and B) was 2.0711 Ma, corresponding to the third major cool period in the Pleistocene. The sea surface temperature fluctuation in the subtropical ancient East China Sea could be the major drivers for the diversification of the two R. festiva clades. It is also suggested that the distribution pattern of Clades A and B is shaped by two major ocean currents. This study provides evidence for the correlation between species diversification and climate change in the NW Pacific during the Pleistocene.
Explainable Deep Learning for Thai Stock Market Prediction Using Textual Representation and Technical Indicators

In this paper, we proposed a deep neural network to predict the Thailand stock market (SET index) with the capability to analyze both numerical and textual inputs altogether. The datasets include twelve-years market data with generated technical indicators (73 time-series) and Thai economic news headlines from various online sources. The proposed model consists of a long-short term memory model and textual representations to predict one-day-ahead percentage market changes. We experiment on two textual representation approaches, which is the Hierarchical neural network and Bidirectional Encoder Representations from Transformers (BERT) together with aggregated embedding. The three-year average experimental results show that adding textual representation increase profit of 6.9% on the proposed strategy-free metric. Next, the Hierarchical approach performs considerably better than the BERT method showing up to 4.4% profit increase. Finally, we demonstrate another advantage of the hierarchical approach for model interpretability using the integrated gradient attribution methods. This interpretability lets us analyze the underlying textual relevance and also for future model improvement.
Research on Fabric Defect Detection Based on Deep Fusion DenseNet-SSD Network

Defect detection to control the quality of fabrics is one of the key tasks in the production process of fabrics. Although significant progress has been made in the research of fabric defect detection, while traditional methods are still difficult to cope with complex and variable defect shapes. In order to solve these problems, this paper proposes an adaptive fabric defect detection method based on DenseNet-SSD algorithm to improve the performance of fabric defect detection. This method uses the DenseNet network to replace the backbone network VGG16 in the SSD algorithm, which strengthens the transfer between feature maps, alleviates the problem of gradient disappearance and reduces the number of network parameters. Compared with SSD, it improves network detection accuracy and real-time performance. The accuracy in the test set is 78.6mAP and the detection speed is 61FPS.
Change of blood sugar and plasma insulin levels of fishes in glucose tolerance test.

In order to compare the ability to utilize carbohydrate of carp Cyprinus carpio, red sea bream Chrysophrys major, and yellowtail Seriola quinqueradiata (which were reared on the diets with 0%, 10%, and 40% dextrin for 30 days), they were subjected to a glucose tolerance test. The fishes istration than the response of normal human beings. The glucose tolerance of yellowtail was lowest, followed by red sea bream, and carp in increasing order. The fishes exhibited a similar pattern of change in plasma insulin levels after the administration of glucose. However, the maximum level of plasma insulin and a ratio of the maximum plasma insulin level to the maximum blood sugar level (Max. IRI/Max. BS) was lowest in yellowtail, followed by red sea bream and carp in increasing order. Futhermore, in all species, the 40% dextrin diet groups showed a higher response of blood sugar, a lower response of insulin, and a lower value of Max. IRI/Max. BS than those of the 0% and 10% groups.