Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of metastatic clones derived from a metastatic variant of mouse colon adenocarcinoma 26.

A spontaneously metastatic variant (P-26-select) was selected from the murine colon adenocarcinoma 26 after repeated (26 times) cyclic in vivo passage of tumor cells from the lungs of mice bearing s.c. tumors. Clones were established from the cultured P-26-select cell line. These clones, the parent [P-no-select (culture cell line of colon 26 without in vivo selection)] and the metastatic variant (P-26-select) were then studied using three different assays to determine their metastatic potential. These assays included experimental metastasis, spontaneous metastasis from a nonresected s.c. growing tumor, and spontaneous metastasis following the resection of a primary footpad tumor. In general, there was an agreement among the results of these three assays of metastases, i.e., if a variant was spontaneously metastatic, it was also metastatic in the other assays of metastases. However, some experimentally metastatic clones did not necessarily show a high spontaneous metastatic potential to the lung. These results might indicate that the metastatic variant (P-26-select) is populated by spontaneously metastatic clones and also by clones which possess a propensity to metastasize experimentally. The morphology and growth properties of the clones were compared also.
Wind energy explained: Theory, Design, and application [Book Review]

WIND ENERGY EXPLAINED: THEORY, Design, and Application, by J.F. Manwell, J.G. McGowan, and A.L. Rogers, is intended to provide both a thorough and highly accessible introduction to the cross-disciplinary field of wind engineering. The economic viability and political appeal of wind power is on the increase, making this text a timely addition to the literature. It was developed to complement the increasing number of renewable/wind energy courses now available, it includes end-of-chapter tutorial sections, and it combines both academic and industrial experience. Its coverage spans every aspect of wind energy engineering
Community factors and hospital readmission rates.

OBJECTIVE To examine the relationship between community factors and hospital readmission rates. DATA SOURCES/STUDY SETTING We examined all hospitals with publicly reported 30-day readmission rates for patients discharged during July 1, 2007, to June 30, 2010, with acute myocardial infarction (AMI), heart failure (HF), or pneumonia (PN). We linked these to publicly available county data from the Area Resource File, the Census, Nursing Home Compare, and the Neilsen PopFacts datasets. STUDY DESIGN We used hierarchical linear models to assess the effect of county demographic, access to care, and nursing home quality characteristics on the pooled 30-day risk-standardized readmission rate. DATA COLLECTION/EXTRACTION METHODS Not applicable. PRINCIPAL FINDINGS The study sample included 4,073 hospitals. Fifty-eight percent of national variation in hospital readmission rates was explained by the county in which the hospital was located. In multivariable analysis, a number of county characteristics were found to be independently associated with higher readmission rates, the strongest associations being for measures of access to care. These county characteristics explained almost half of the total variation across counties. CONCLUSIONS Community factors, as measured by county characteristics, explain a substantial amount of variation in hospital readmission rates.
Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin.

Leptin is a polypeptide, mainly produced in white adipose tissue, and increases sympathetic nerve activity. A few studies investigated leptin's effect on peripheral vessels. We examined the vasorelaxant effects of human leptin on rat arteries. Arterial rings were precontracted with 1 x 10(-6) mol/l of phenylephrine, and leptin was superfused. Leptin relaxed phenylephrine-precontracted arterial rings in a dose-dependent manner. ED50 was calculated to 8.4 microg/ml. Removal of endothelium abolished the effects of leptin. Indomethacin (1 x 10(-5) mol/l) did not affect the vasorelaxation by leptin, whereas 1 x 10(-4) mol/l of N(omega)-nitro-L-arginine methyl ester (L-NAME) completely suppressed it. The inhibition was antagonized by 1 x 10(-4) mol/l of L-arginine. Leptin normally relaxed arterial rings during superfusion of K channel blockers, including 3 x 10(-5) mol/l of glibenclamide, 1 x 10(-6) of mol/l apamin, and 5 x 10(-7) mol/l of charybdotoxin. Low Cl(-) solution (8. 3 mmol/l) inhibited leptin-induced relaxation, but endothelium-independent vasodilatation by nitroprusside was not impaired at low Cl(-) solution. These results suggest that arterial relaxation by leptin is mediated by nitric oxide released from endothelium, and Cl(-) plays an important role in leptin-induced nitric oxide release.
Sulfated proteoglycans in the extracellular matrix of human breast tissues with infiltrating carcinoma

The size, content and distribution of sulfated proteoglycans, constituents of the extracellular matrix, were investigated in non‐neoplastic human breast tissues and in tissues with infiltrating carcinoma. Sulfated proteoglycans were identified as cupro‐linic‐blue‐positive elements on electron microscopy preparations by the method of the critical electrolyte concentration. Morphometric data indicated that the numerical density of PG per surface area (Na) in normal tissues was about 2 to 7 times higher respectively in dense or loose connective zone then that found in the corresponding zones of malignant tissues. By referring to the unit volume of tissue, the overall PG content (Nv) was found to be increased about 5 fold in nonneoplastic tissues. However, in tissues with carcinoma the average length of sulfated proteoglycans was about twice as long in dense and loose connective layers than in the corresponding connective zones of non‐neoplastic breast tissues. Our findings provide evidence of profound structural alterations of non‐collagenous constituents in the extracellular matrix of human mammary tissues concerned with infiltrating carcinoma.
High frequency ultrasound ( 22 MHz ) in the evaluation of malignant cutaneous neoplasms

Financial support: None Conflict of interest: None ABSTRACT Dermatologists have recently been incorporating diagnostic imaging techniques in the investigation of cutaneous lesions. The development of ultrasound devices with a frequency greater than 15MHz has led to the creation of the high-frequency ultrasound (HFUS), which enables the identification of the skin’s different layers and structures as well as appendages. This has expanded its use considerably in various dermatological conditions, particularly in cutaneous neoplasms. Its association with color Doppler allows the study of tumor microcirculation. In the present paper, the authors discuss the main clinical characteristics of malignant cutaneous neoplasms and how high-frequency ultrasound allows a better pre-operative evaluation of those lesions.
Characterization of mouse cellular deoxyribonucleic acid homologous to Abelson murine leukemia virus-specific sequences

The genome of Abelson murine leukemia virus (A-MuLV) consists of sequences derived from both BALB/c mouse deoxyribonucleic acid and the genome of Moloney murine leukemia virus. Using deoxyribonucleic acid linear intermediates as a source of retroviral deoxyribonucleic acid, we isolated a recombinant plasmid which contained 1.9 kilobases of the 3.5-kilobase mouse-derived sequences found in A-MuLV (A-MuLV-specific sequences). We used this clone, designated pSA-17, as a probe restriction enzyme and Southern blot analyses to examine the arrangement of homologous sequences in BALB/c deoxyribonucleic acid (endogenous Abelson sequences). The endogenous Abelson sequences within the mouse genome were interrupted by noncoding regions, suggesting that a rearrangement of the cell sequences was required to produce the sequence found in the virus. Endogenous Abelson sequences were arranged similarly in mice that were susceptible to A-MuLV tumors and in mice that were resistant to A-MuLV tumors. An examination of three BALB/c plasmacytomas and a BALB/c early B-cell tumor likewise revealed no alteration in the arrangement of the endogenous Abelson sequences. Homology to pSA-17 was also observed in deoxyribonucleic acids prepared from rat, hamster, chicken, and human cells. An isolate of A-MuLV which encoded a 160,000-dalton transforming protein (P160) contained 700 more base pairs of mouse sequences than the standard A-MuLV isolate, which encoded a 120,000-dalton transforming protein (P120).
Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies

Oncolytic viruses (OVs) are multimodal cancer therapeutics, with one of their dominant mechanisms being in situ vaccination. There is a growing consensus that optimal cancer therapies should generate robust tumor-specific immune responses. Immunogenic cell death (ICD) is a paradigm of cellular demise culminating in the spatiotemporal release of danger-associated molecular patterns that induce potent anticancer immunity. Alongside traditional ICD inducers like anthracycline chemotherapeutics and radiation, OVs have emerged as novel members of this class of therapeutics. OVs replicate in cancers and release tumor Ags, which are perceived as dangerous because of simultaneous expression of pathogen-associated molecular patterns that activate APCs. Therefore, OVs provide the target Ags and danger signals required to induce adaptive immune responses. This review discusses why OVs are attractive candidates for generating ICD, biological barriers limiting their success in the clinic, and groundbreaking strategies to potentiate ICD and antitumor immunity with rationally designed OV-based combination therapies.
Quantized Compressive Sensing for Low-Power Data Compression and Wireless Telemonitoring

In low-power wireless telemonitoring, physiological signals must be compressed before transmission to extend battery life. In this paper, we propose a two-stage data compressor based on quantized compressive sensing (QCS), where signals are first compressed by compressive sensing with a 50% compression ratio and then quantized with 2 bits per measurement. We also develop a reconstruction algorithm, called Bayesian de quantization (BDQ), to recover signals from the quantized compressed measurements. This algorithm exploits both the model of quantization errors and the correlated structure of physiological signals, which improves the quality of recovery. We validate the proposed data compressor and the recovery algorithm on wrist-type photoplethysmography data. This data are used to estimate the heart rate during fitness training. Results show that an average estimation error of 2.596 beats per minute is achieved using QCS and BDQ. This accuracy approaches the performance on non-compressed data, but we transmit n bits instead of n samples, which is a substantial improvement for low-power telemonitoring.
PSEUDOMONAS (FLAVOBACTERIUM) PISCICIDA BEIN COMB. NOV

tion Proc. 22:618, 1963), in a study of intracellular B. abortus by use of an electron microscope, reported that the progeny of phagocytized Brucella appear to remain within an ingestion vacuole. Membranes are not always found surrounding foreign particles, however. Litwin (J. Infect. Diseases 105:129, 1959; Ann. .N.Y. Acad. Sci. 98:145, 1962) showed that feline pneumonitis and trachoma viruses, growing within cells of the chorioallantoic membrane of the chick embryo, are not found in membrane-bound vesicles. Dale et al. (J. Biophys. Biochem. Cytol. 10:475, 1961) reported that 1 hr after infection vaccinia virus was found to lie freely in the cytoplasm in the majority of infected L cells. Chapman et al. (Am. J. Pathol. 42:619, 1963) demonstrated virus-like particles lying free in the cytoplasm of human wart cells. The presence of a membrane around intracellular Brucella, therefore, may indicate further differences between facultative and obligate intracellular parasites. The origin and possible significance of the surrounding membrane in the infection process remains to be determined. In agreement with the findings of Kessel et al., we found no differences in the morphology of intraand extracellular Brucella at this short time interval. Further observations at extended time intervals are necessary to establish whether Brucella undergo morphological changes in the intracellular environment.
Pitfalls and Windfalls in Corpus Studies of Pop / Rock Music

Background Over the past few decades, computational methods involving annotated collections of music—i.e., corpus studies— have emerged as a promising subfield within music research (cf. Temperley and VanHandel 2013; Shanahan 2016), afforded especially by recent developments in computing technology. In more recent years, corpus methods have begun to be used in the analysis of popular music. Extant corpora of pop/rock music, for example, range from those complied by a single author (e.g., Summach 2012; Tough 2013), to those created by multiple authors (e.g., Burgoyne et al. 2011; Temperley and de Clercq 2013), to those generated by computer algorithms (e.g., Bertin-Mahieux et al. 2011).
FurtherRemarks onStrict Input-to-State Stable LyapunovFunctions forTime-VaryingSystems ?

We study the stability properties of a class of time-varying nonlinear systems. We assume that non-strict input-to-state stable (ISS) Lyapunov functions for our systems are given and posit a mild persistency of excitation condition on our given Lyapunov functions which guarantee the existence of strict ISS Lyapunov functions for our systems. Next, we provide simple direct constructions of explicit strict ISS Lyapunov functions for our systems by applying an integral smoothing method. We illustrate our constructions using a tracking problem for a rotating rigid body.
The Effect of Socioeconomic Status on the Survival of People Receiving Care for HIV Infection in the United States

HIV-infected people with low socioeconomic status (SES) and people who are members of a racial or ethnic minority have been found to receive fewer services, including treatment with Highly Active Antiretroviral Therapy (HAART), than others. We examined whether these groups also have worse survival than others and the degree to which service use and antiretroviral medications explain these disparities in a prospective cohort study of a national probability sample of 2,864 adults receiving HIV care. The independent variables were wealth (net accumulated financial assets), annual income, educational attainment, employment status (currently working or not working), race/ethnicity, insurance status, use of services, and use of medications at baseline. The main outcome variable was death between January 1996 and December 2000. The analysis was descriptive and multivariate adjusted Cox proportional hazards regression analysis of survival. By December 2000, 20% (13% from HIV, 7% non-HIV causes) of the sample had died. Those with no accumulated financial assets had an 89% greater risk of death (RR=1.89, 95% CI=1.15–3.13) and those with less than a high school education had a 53% greater risk of death (RR=1.53, 95% CI=1.15–2.04 ) than their counterparts, after adjusting for sociodemographic and clinical variables only. Further adjusting for use of services and antiretroviral treatment diminished, but did not eliminate, the elevated relative risk of death for those with low SES by three of the four measures. The finding of markedly elevated relative risks of death for those with HIV infection and low SES is of particular concern given the disproportionate rates of HIV infection in these groups. Effective interventions are needed to improve outcomes for low SES groups with HIV infection.
The Benefits, Limitations, and Cost-Effectiveness of Advanced Technologies in the Management of Patients With Diabetes Mellitus

Background: Hypoglycemia mitigation is critical for appropriately managing patients with diabetes. Advanced technologies are becoming more prevalent in diabetes management, but their benefits have been primarily judged on the basis of hemoglobin A1c. A critical appraisal of the effectiveness and limitations of advanced technologies in reducing both A1c and hypoglycemia rates has not been previously performed. Methods: The cost of hypoglycemia was estimated using literature rates of hypoglycemia events resulting in hospitalizations. A literature search was conducted on the effect on A1c and hypoglycemia of advanced technologies. The cost-effectiveness of continuous subcutaneous insulin infusion (CSII) and real-time continuous glucose monitors (RT-CGM) was reviewed. Results: Severe hypoglycemia in insulin-using patients with diabetes costs $4.9-$12.7 billion. CSII reduces A1c in some but not all studies. CSII improves hypoglycemia in patients with high baseline rates. Bolus calculators improve A1c and improve the fear of hypoglycemia but not hypoglycemia rates. RT-CGM alone and when combined with CSII improve A1c with a neutral effect on hypoglycemia rates. Low-glucose threshold suspend systems reduce hypoglycemia with a neutral effect on A1c, and low-glucose predictive suspend systems reduce hypoglycemia with a small increase in plasma glucose levels. In short-term studies, artificial pancreas systems reduce both hypoglycemia rates and plasma glucose levels. CSII and RT-CGM are cost-effective technologies, but their wide adoption is limited by cost, psychosocial, and educational factors. Conclusions: Most currently available technologies improve A1c with a neutral or improved rate of hypoglycemia. Advanced technologies appear to be cost-effective in diabetes management, especially when including the underlying cost of hypoglycemia.
Observer-based event-triggered control for consensus of multi-agent systems with time delay

This paper studies the consensus of general linear multi-agent systems with or without time delays. The observer-based event-triggered control schemes will be considered. For the conventional distributed consensus protocol, we will not update the relative state in continuous time, i.e., the relative state will be updated by some events which happened in discrete time. A completely decentralized event-trigger will be designed for multi-agent systems. It is shown that all agents can achieve consensus by the proposed protocol, if we design some appropriate feedback gain matrices. Numerical simulations are also provided and the results show highly consistent with the theoretical results.
Popular Summary “ Overlap properties of clouds generated by a Cloud Resolving Models

The overlap properties of -850 snapshots of convective cloud fields generated by a Cloud Resolving Model are studied and compared with previously published results based on cloud radar observations. Total cloud fraction is overestimated by the random overlap assumption and underestimated by the maximum overlap assumption, as well as two standard implementations of the combined maximumhandom overlap assumption. When the overlap of two layers is examined as a function of vertical separation distance, the value of the parameter a measuring the relative weight of maximum ( ~ 1 ) and random (PO) overlap decreases in such a way that only layers less than 1 km apart can be considered maximally overlapped, while layers more than 5 km apart are essentially randomly overlapped. The decrease of a with separation distance is best expressed by a power law; exponential behaviour is, however, still a good approximation for separation distances up to 5 km.
A 2 year, open ended trial of methotrexate in systemic lupus erythematosus.

OBJECTIVE To investigate a possible role for methotrexate (MTX) in the treatment of patients with systemic lupus erythematosus (SLE) who require unacceptably high doses of glucocorticosteroids (GCS) for control of their disease. METHODS Twelve patients with SLE participated in this open ended prospective study. Patients with active renal or central nervous system (CNS) disease were excluded as were patients with liver disease. Serological variables, SLE disease activity index, joint count, and prednisone dose were serially evaluated. Data were analyzed using paired t test and contingency table analysis. RESULTS Arthritis was the major persistent problem in 7 patients: 1 patient had recurrent pleuropericarditis, 2 patients had refractory cutaneous lupus rashes and 2 had vasculitis. Three patients discontinued MTX because of side effects. The remaining 9 patients have been treated from 7-26 months. In 6 patients the GCS dose was reduced by an average of 42%. In 1 patient symptoms subsided and joint count was reduced without change in the GCS dose. GCS dosage was increased in 2 patients: 1 with recurrent serositis, 1 with persistent vasculitis. No apparent effect on anti-dsDNA antibodies, complement or erythrocyte sedimentation rate (ESR) was noted. CONCLUSION MTX appears to be useful in selected patients with SLE, especially those with persistent synovitis.
Benign breast disease at Wesley Guild Hospital, Ilesha, Nigeria.

UNLABELLED A prospective survey of 225 patients carried out over a period of 7years (1992 - 1999) to determine the pattern and outcome of benign breast diseases. Two hundred and seventeen (96.4%) were females and 8 males, with the age ranging from 14-63 years, mean 28.7 SD+10.6 years. The mean age for patients with fibroadenoma was 24 years and 31.6 years for fibrocystic disease of the breast. One hundred and ninety six patients (87.2%) presented with breast lumps or mass, non-menstrual cycle and menstrual cycle related pain in 39(17.3%) and 32(13%) patients respectively and nipple discharge in 60 patients (26.7%). Mean duration of symptoms was 0.91+0.64 years, 2 + 1.2 weeks for inflammatory lesions and 0.86 + 0.56 yers for benign tumours and also menstrual cycle related breast pain. Right side was involved in 162 patients (72%), 85(38%) left side and 77(34.2%) bilateral. Clinical diagnosis was fibrocystic disease 96(42.7%). Fibroadenoma 89 (39.5%), inflammatory conditions 35(15.7%), galactocele in 9(40%) and gynaecomastia in 7(3%) of the patients. Excisional or incisional biopsy was carried out in 197 patients (87.5%), antibiotic and analgestic administration in 35(15.6%) and 29(13%), respectively. Histopathologic analysis showed fibroadenoma in 91 (46.2%), fibrocystic disease 83 (42.2%), and others in 23 (11.6%) cases. The mean follow-up period was 10 months for tumours and I month for others. Postoperative complications were infrequent, there were recurrence either on the ipsilateral or contralateral breast in 10(4.4%) patients of which 3(1.3%) cases were malignant. CONCLUSION Fibroadenoma was the most common benign breast disease, followed by fibrocystic disease of the breast. Postoperative complications were uncommon.