Miracle-dz/UniFAR-FTUs huggingface dataset:
Validating the Voodoo Doll Task as a Proxy for Aggressive Parenting Behavior.

OBJECTIVE Six studies (N = 1,081 general population parents) assessed the validity of the Voodoo Doll Task (VDT) as a proxy for aggressive parenting behaviors. METHODS Participants were given an opportunity to symbolically inflict harm by choosing to stick "pins" into a doll representing their child. RESULTS Individual differences in parents' trait aggression (Studies 1, 2, and 6), state hostility (Study 3), attitudes towards the corporal punishment of children (Study 4), self-control (Study 6), depression (Study 6), and child physical abuse risk (Study 6) were associated with increased pin usage. Further, parents used more pins after imagining their child perform negative behaviors compared to after imagining their child perform positive behaviors (Study 5). A number of demographic variables also were associated with pin usage: Fathers used pins more than mothers and parents' education level was inversely related to pin usage. Finally, on average, parents viewed the VDT as slightly uncomfortable, but not objectionable, to complete (Study 6). CONCLUSIONS Our evidence suggests that the VDT may serve as a useful proxy for parent-to-child aggression.
A Zero Current Switching AC-AC Resonant Converter for Three Phase Induction Heating

This paper proposes the concept of three phase AC to AC resonant converter for Induction heater. As compared with basic converters, AC to AC resonant converter has advantages of less components count, low cost, high reliability and better efficiency. A closed loop control structure is proposed in this paper for controlling three phase resonant converter. Finally, this proposed system is experimentally verified using Matlab/Simulink.
Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures

Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters. Design Prospective, open-label, long-term mechanism of action study. Setting University clinic. Methods MTX was initiated at a single weekly oral dose of 7.5 mg and dose adjusted for efficacy and toxicity for the duration of the study. Standard measures of disease activity were performed at baseline and every 6–36 months. Serum cytokine measurements in blood together with lymphocyte surface immunophenotypes and stimulated peripheral blood mononuclear cell (PBMC) cytokine production were assessed at each clinical evaluation. Results Cytokine concentrations exhibited multiple significant correlations with disease activity measures over time. The strongest correlations observed were for interleukin (IL)-6 (r=0.45, p<0.0001 for swollen joints and r=0.32, p=0.002 for tender joints) and IL-8 (r=0.25, p=0.01 for swollen joints). Significant decreases from baseline were observed in serum IL-1B, IL-6 and IL-8 concentrations. The most significant changes were observed for IL-6 (p<0.001). Significant increases from baseline were observed in IL-2 release from PBMCs ex vivo (p<0.01). In parallel, multiple statistically significant correlations were observed between MTX PKC measures and immune parameters. The change in swollen joint count correlated inversely with the change in area under the curve (AUC) for MTX (r=−0.63, p=0.007). Conclusions MTX therapy of patients with RA is accompanied by a variety of changes in serum cytokine expression, which in turn correlate strongly with clinical disease activity and MTX pharmacokinetics (PKCs). These data strongly support the notion that MTX mediates profound and functionally relevant effects on the immunological hierarchy in the RA lesion.
Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report

Rhinitis is an umbrella term that encompasses many different subtypes, several of which still elude complete characterization. The concept of phenotyping, being the definition of disease subtypes on the basis of clinical presentation, has been well established in the last decade. Classification of rhinitis entities on the basis of phenotypes has facilitated their characterization and has helped practicing clinicians to efficiently approach rhinitis patients. Recently, the concept of endotypes, that is, the definition of disease subtypes on the basis of underlying pathophysiology, has emerged. Phenotypes/endotypes are dynamic, overlapping, and may evolve into one another, thus rendering clear‐cut definitions difficult. Nevertheless, a phenotype‐/endotype‐based classification approach could lead toward the application of stratified and personalized medicine in the rhinitis field. In this PRACTALL document, rhinitis phenotypes and endotypes are described, and rhinitis diagnosis and management approaches focusing on those phenotypes/endotypes are presented and discussed. We emphasize the concept of control‐based management, which transcends all rhinitis subtypes.
Pubertal Changes in Serum Leptin Levels in Adolescents with Type 1 Diabetes Mellitus: A Controlled Longitudinal Study

The mechanism of the pubertal delay seen in some adolescents with type 1 diabetes mellitus is not entirely clear. Since leptin has been implicated as a neuroendocrine modulator of puberty, we measured serum leptin levels longitudinally in 24 post-'honeymoon' patients with diabetes mellitus (M/F = 15/9) with a mean (+/- SD) age of 10.5 +/- 0.9 years and 26 controls (M/F = 15/11) with a mean age of 10.0 +/- 1.1 years. Physical examinations; serum leptin, IGF-I, IGFBP-3 and IGFBP-1 levels; and bone age X-rays were performed annually for up to 48 months. Glycosylated hemoglobin (HbA1c) was measured 2-4 times a year in patients with diabetes mellitus. Serum leptin levels strongly correlated with the body mass index z-scores (BMI-Z) in both controls (r = 0.666, p <0.00001) and diabetic patients (r = 0.577, p <0.00001). Girls had increased serum leptin levels for a given BMI compared to boys (p <0.005). There were no significant differences in serum leptin levels of patients with diabetes mellitus compared to controls, nor were differences seen when the groups were stratified by age, Tanner stage, or gender. There were also no significant correlations between serum leptin levels and degree of metabolic control (i.e. HbA1c) or insulin dose standardized for body weight. Although there was no significant diabetes-related or metabolic control-related delay in bone age z-score or pubertal development, there was a significant negative correlation between HbA1c and growth velocity z-score, indicating that children with poor diabetes control had modest but significant slowing of growth. It is concluded that neither pubertal development nor serum leptin levels are significantly altered in adolescents with diabetes mellitus managed with standard therapy. The potential role of leptin in initiation of pubertal development is not easily demonstrable in observational studies.
Electrostatic Graphene Loudspeaker

Graphene has extremely low mass density and high mechanical strength, and key qualities for efficient wide-frequency-response electrostatic audio speaker design. Low mass ensures good high frequency response, while high strength allows for relatively large free-standing diaphragms necessary for effective low frequency response. Here, we report on construction and testing of a miniaturized graphene-based electrostatic audio transducer. The speaker/earphone is straightforward in design and operation and has excellent frequency response across the entire audio frequency range (20 Hz–20 kHz), with performance matching or surpassing commercially available audio earphones.
La formación de una cartera óptima de activos: una guía para no especialistas

La gestion financiera ha sufrido un acelerado proceso de sofisticacion en las ultimas decadas. La complejidad de algunos productos financieros ha sido citada, incluso, como una de las causas de la actual crisis financiera, en cuyo origen se situa la crisis de las hipotecas «subprime». Este articulo no pretende ser una guia de autoayuda para que cualquier persona no especialista en finanzas pueda abordar la dificil tarea de construccion de una cartera optima de activos, sino aportar un esquema a seguir para entender las fases que un especialista completa hasta la construccion de una cartera optima, asi como conocer los factores que hay que tener en cuenta para evaluar correctamente el riesgo financiero y el grado de aversion al mismo de los inversores. En definitiva, se pretende aportar al no especialista una serie de instrumentos para poder evaluar correctamente la gestion realizada por el especialista.
Classification using Machine Learning Techniques

Large amount of information are available online on web.The discussion forum, review sites, blogs are some of the opinion rich resources where review or posted articles is their sentiment, or overall opinion towards the subject matter. The opinions obtained from those can be classified in to positive or negative which can be used by customer to make product choice and by businessmen for finding customer satisfaction . This paper studies online movie reviews using sentiment analysis approaches. In this study, sentiment classification techniques were applied to movie reviews. Specifically, we compared two supervised machine learning approaches SVM, Navie Bayes for Sentiment Classification of Reviews. Results states that Naïve Bayes approach outperformed the svm. If the training dataset had a large number of reviews, Naive bayes approach reached high accuracies as compare to other.
Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery

Introduction: Cancer cells acclimatize to the harsh tumor microenvironment by altering cellular metabolism in favor of aerobic glycolysis. This process provides a source of energy and also generates essential components for macromolecular biosynthesis, which enables cellular survival. As the dependence of cancer cells on glycolysis affects tumorigenesis, it has become an attractive target for therapeutic intervention. Several preclinical studies have shown the effectiveness of using biological targets from the glycolytic pathway for anticancer therapy. Areas covered: This review provides an insight into the glycolytic pathway, highlighting potential targets for glycolytic inhibition. We then discuss recent advancement in delivery strategies that have the potential to circumvent some of the problems posed by current glycolytic inhibitors, enabling resurrection of abandoned therapeutic agents. Expert opinion: Targeting the glycolysis pathway is a tactical approach for cancer therapy. However, the current nonspecific therapeutic strategies have several drawbacks such as poor bioavailability, unfavorable pharmacokinetic profile and associated nonspecific toxicity, thereby limiting preclinical investigation. In recent years, nanoparticle systems have received recognition for the delivery of therapeutic agents directly to the tumor tissue. Thus, it is envisaged that this strategy can be expanded for the delivery of current glycolytic inhibitors specifically to tumor tissues providing improved anticancer activity.
Histone H2B gene transcription during Xenopus early development requires functional cooperation between proteins bound to the CCAAT and octamer motifs

The ubiquitously expressed transcription factor Oct-1 and several other members of the POU domain protein family bind to a site, termed the octamer motif, that functions in the promoter and enhancer regions of a variety of genes expressed under diverse conditions. An octamer motif present in a conserved histone H2B-specific promoter element is required for S-phase-specific transcription of mammalian histone H2B genes in cultured cells. We have previously shown that the octamer motif in a Xenopus histone H2B gene promoter was inactive in nondividing frog oocytes. Here we show that the octamer motif, in addition to regulatory elements (TATAA, CCAAT, and ATF motifs) that are active in oocytes, is required for maximal H2B gene transcription in developing frog embryos. Factors binding to each of the H2B upstream promoter elements are present in oocytes and increase slightly in abundance during early development. The activity of the H2B octamer motif in embryos is not specifically associated with increased binding by Oct-1 or the appearance of novel octamer-binding proteins but requires the presence of an intact CCAAT motif. Our results indicate that synergistic interactions among promoter-bound factors are important for octamer-dependent H2B transcription. We suggest that the activity of the H2B promoter is regulated primarily by changes in the interactions between proteins already bound to the promoter rather than by alterations in their intrinsic abilities to bind DNA.
Prospective evaluation of a protocol for reduced glucocorticoid replacement in transsphenoidal pituitary adenomectomy: prophylactic glucocorticoid replacement is seldom necessary

Background Most pituitary surgery centres prescribe perioperative glucocorticoids to subjects undergoing transsphenoidal pituitary adenomectomy (TSA), despite reports suggesting this may be unnecessary. Evidence‐based guidelines for glucocorticoid use in TSA have recently been published but there are no prospective studies of their utility.
Molecular Basis for LLT1 Protein Recognition by Human CD161 Protein (NKRP1A/KLRB1)

Human Th17 cells express high levels of CD161, a member of the killer cell lectin-like receptor (KLR) family (also referred to as NK receptor-P1A (NKRP1A) or KLRB1), as a representative marker. CD161 is also expressed on natural killer (NK) cells and NKT cells. Lectin-like transcript 1 (LLT1), another KLR family member, was recently identified as a ligand for CD161. This interaction may play pivotal roles in the immunomodulatory functions of Th17 cells as well as those of NK and NKT cells. However, the molecular basis for the interaction is poorly understood. Here we show that the extracellular domain of CD161 bound directly to LLT1 with a Kd of 48 μm and with the fast kinetics typical of cell-cell recognition receptors. Mutagenesis revealed that the similar membrane-distal β-sheet and loop regions of both CD161 and LLT1 were utilized for the binding, and notably, these regions correspond to the ligand-binding sites for major histocompatibility complex (MHC)-recognizing KLRs. Furthermore, we found a pair of detrimental mutations for both molecules that restored the binding. These results reveal a new template model for the recognition mode between the KLR family members and provide insights into the molecular mechanism underlying Th17/NK/NKT-mediated immune responses.
LA CULTURA EN las organizaciones empresariales

Este trabajo tiene como proposito hacer la propuesta de un concepto de cultura que pretende ser util para el estudio de las organizaciones empresariales y de los actores sociales que en ellas participan. La propuesta se constniye sobre la base del analisis y del acercamiento de tres perspectivas: los estudios sobre cultura organizacional, los estudios mexicanos sobre cultura obrera y la corriente socio-antropologica que define la cultura como significacion. Cada una de estas tradiciones teoricas aporta elementos valiosos que, sistematizados en un conjunto coherente, contribuyen a la constitucion de una teoria de la cultura que tiene un valor heuristico para la investigacion en el campo de las organizaciones empresariales y sus actores. El trabajo tiene cuatro partes. En la primera se ubican los estudios culturales en el panorama actual de los estudios sobre las organizaciones. En la segunda se analizan las propuestas teoricas de los estudiosos de la cultura organizacional. En la tercera se analizan las aportaciones de los estudios mexicanos sobre cultura obrera. En la ultima parte se hace el planteamiento de la propuesta teorica que relaciona la perspectiva socio-antropologica con las otras dos, y se pone un ejemplo que hace ver su utilidad para el estudio de las organizaciones empresariales y sus actores.
W-band transmitter and receiver modules for 10-Gb/s impulse radio

Using InP HEMT technologies, we developed transmitter and receiver modules based on impulse radio (IR) architecture that are capable of 10-Gb/s data transmission in W-band frequencies. The new modules achieve ON/OFF keying modulation without using local oscillators, mixers, or other components that had been needed in previous millimeter-band modules. The transmitter, consisting of a 6.5-ps pulse modulator and a band-pass filter with 5-stage microstrip coupled lines, emits wavelets, or RF pulses, with a full width at half maximum of less than 80 ps and a voltage amplitude of 76 mVpp, occupying frequencies between 78–93 GHz. The receiver is composed of a low-noise amplifier (LNA), an envelope detector, and a limiting amplifier. The group delay property of the LNA, opposite to that of a waveguide to microstrip line transition in the module, makes the received signal distortion smaller, resulting in a reduction in intersymbol interference (ISI). As results of a back-to-back test, error free transmission/reception (BER≪10−12) was confirmed with a test pattern of PRBS 231-1 at the OC-192 compliant data rate of 9.95328 Gb/s. These results established the basic technologies for simple and compact IR-based systems, which could be used as an alternative to fiber optic cables.
Narrative Structure in Maupassant: Frames of Desire

This essay explores the dynamics of framed narrative through readings of two Maupassant stories that illustrate the range of potential in the frame. Scrutiny of “La rempailleuse” and “En voyage” reveals, in particular, how a frame modifies the effect of, and reaction to, the narrative it surrounds. The more general principle that emerges is that the seemingly gratuitous border consisting of the “extra” narrator and his addressees operates, paradoxically, against closure, casting the reader into a metacommunicative realm where a second sign system springs from the first. Thus, in “En voyage,” romantic love, the thematic content, serves as the basis for a poetics of narrative and illuminates the larger implications of the interminability of the paratactic structure. Issues addressed are the strategies latent in the frame and the way the form itself calls into question the very nature and function of narrative.
Adaptive magnetizing current observer of single-phase collector motor drive

Adaptive magnetizing current observer of single-phase collector motor has been proposed in the paper. The electro-mechanical energy conversion in a single-phase collector motor is being represented trough a system of nonlinear differential equations that includes the resistances and dynamic inductivities of the armature and field winding, spinning E.M. F. The observer gain matrix is designed to achieve quickly and accurately performance by the definition of a non-linear reference model. The experimental results show the improvements with regard to the robustness of parameter uncertainties and load disturbances in the proposed scheme. The observer performance has been very good even though the load torque is varying.
Cytolysis by CCR5-Using Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Is Dependent on Membrane Fusion and Can Be Inhibited by High Levels of CD4 Expression

ABSTRACT T-tropic (X4) and dualtropic (R5X4) human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins kill primary and immortalized CD4+ CXCR4+ T cells by mechanisms involving membrane fusion. However, because much of HIV-1 infection in vivo is mediated by M-tropic (R5) viruses whose envelope glycoproteins use CCR5 as a coreceptor, we tested a panel of R5 and R5X4 envelope glycoproteins for their ability to lyse CCR5+ target cells. As is the case for CXCR4+ target cells, HIV-1 envelope glycoproteins expressed by single-round HIV-1 vectors killed transduced CD4+ CCR5+ cells in a membrane fusion-dependent manner. Furthermore, a CD4-independent R5 HIV-1 envelope glycoprotein was able to kill CD4-negative target cells expressing CCR5, demonstrating that CD4 is not intrinsically required for the induction of death. Interestingly, high levels of CD4 expression protected cells from lysis and syncytium formation mediated by the HIV-1 envelope glycoproteins. Immunoprecipitation experiments showed that high levels of CD4 coexpression inhibited proteolytic processing of the HIV-1 envelope glycoprotein precursor gp160. This inhibition could be overcome by decreasing the CD4 binding ability of gp120. Studies were also undertaken to investigate the ability of virion-bound HIV-1 envelope glycoproteins to kill primary CD4+ T cells. However, neither X4 nor R5X4 envelope glycoproteins on noninfectious virions caused death in primary CD4+ T cells. These results demonstrate that the interaction of CCR5 with R5 HIV-1 envelope glycoproteins capable of inducing membrane fusion leads to cell lysis; overexpression of CD4 can inhibit cell killing by limiting envelope glycoprotein processing.
Parent‐Child Relationship Disorders. Part I. Parental Overprotection and the Development of the Parent Protection Scale

There is a spectrum of parental protective behaviors promoting child safety and security, ranging from neglect to overprotection. This paper describes the development and psychometric properties of a new measure of parental protective behaviors toward children age 2 to 10 years, the Parent Protection Scale (PPS). Items were selected to represent key dimensions of protective behaviors. Factor analyses suggested four subscales: Supervision, Separation Problems, Dependence, and Control. The PPS has acceptable internal consistency, test-retest reliability, and clinical validity. Norms by child age in the form of cutoff points corresponding to +1 SD were determined. Clinical and research uses for the PPS are noted.
Effects on Carbon Storage of Conversion of Old-Growth Forests to Young Forests

Simulations of carbon storage suggest that conversion of old-growth forests to young fast-growing forests will not decrease atmospheric carbon dioxide (CO2) in general, as has been suggested recently. During simulated timber harvest, on-site carbon storage is reduced considerably and does not approach old-growth storage capacity for at least 200 years. Even when sequestration of carbon in wooden buildings is included in the models, timber harvest results in a net flux of CO2 to the atmosphere. To offset this effect, the production of lumber and other long-term wood products, as well as the life-span of buildings, would have to increase markedly. Mass balance calculations indicate that the conversion of 5 x 109 to 1.8 x 109 megagrams of carbon to the atmosphere.