Miracle-dz/UniFAR-FTUs huggingface dataset:
Body Dissatisfaction in Women With Eating Disorders: Relationship to Early Separation Anxiety and Insecure Attachment

Objective: It has been suggested that an insecure style of attachment may be one of the factors implicated in the etiology of body dissatisfaction, which, in turn, is a risk factor for eating disorders. The present study analyzed the association among early separation anxiety, insecure attachment, and body dissatisfaction in a clinical sample of 96 women with anorexia nervosa (n = 31) or bulimia nervosa (n = 65). Methods: Body dissatisfaction was measured using the Body Shape Questionnaire (BSQ), early separation anxiety was measured using the Separation Anxiety Symptom Inventory (SASI), and adult attachment style was measured using the Attachment Style Questionnaire (ASQ). Results: In both anorectic and bulimic women, BSQ scores were strongly correlated with SASI and ASQ scores. In a hierarchical regression model controlling for the confounding effects of body mass index and depressive symptoms, early separation anxiety and preoccupied attachment emerged as significant predictors of high levels of body dissatisfaction. Conclusions: Based on the cross-sectional findings of this study, insecure attachment appears to be a consistent correlate of negative body image evaluations in women with either anorexia nervosa or bulimia nervosa. If future prospective studies will confirm that an insecure style of attachment plays a role in promoting the development of body dissatisfaction, prevention and treatment of disordered eating pathology might be enhanced by focusing greater attention on attachment relationships. AN = anorexia nervosa; ASQ = Attachment Style Questionnaire; BDI = Beck Depression Inventory; BN = bulimia nervosa; BMI = body mass index; BSQ = Body Shape Questionnaire; SASI = Separation Anxiety Symptom Inventory.
New least squares registration algorithm for data fusion

A new least-squares registration (NLSR) algorithm is developed to accurately estimate and correct the systematic errors of a data fusion system. First, the two-sensor registration problem is expressed by an averaged least-squares (LS) criterion function of the sensor measurements. The criterion function is optimized by a Newton algorithm. Then, the algorithm is extended to multiple-sensor case. The accuracy of the proposed estimation scheme achieves the Cramer-Rao bound (CRB). Theoretical analysis and simulations are employed to assess the performance of the proposed algorithm.
Segregation of non‐p.R132H mutations in IDH1 in distinct molecular subtypes of glioma

Mutations in the gene encoding the isocitrate dehydrogenase 1 gene (IDH1) occur at a high frequency (up to 80%) in many different subtypes of glioma. In this study, we have screened for IDH1 mutations in a cohort of 496 gliomas. IDH1 mutations were most frequently observed in low grade gliomas with c.395G>A (p.R132H) representing >90% of all IDH1 mutations. Interestingly, non‐p.R132H mutations segregate in distinct histological and molecular subtypes of glioma. Histologically, they occur sporadically in classic oligodendrogliomas and at significantly higher frequency in other grade II and III gliomas. Genetically, non‐p.R132H mutations occur in tumors with TP53 mutation, are virtually absent in tumors with loss of heterozygosity on 1p and 19q and accumulate in distinct (gene‐expression profiling based) intrinsic molecular subtypes. The IDH1 mutation type does not affect patient survival. Our results were validated on an independent sample cohort, indicating that the IDH1 mutation spectrum may aid glioma subtype classification. Functional differences between p.R132H and non‐p.R132H mutated IDH1 may explain the segregation in distinct glioma subtypes. © 2010 Wiley‐Liss, Inc.
Next generation optical access technologies

The TWDM-PON primary solution for FSAN NG-PON2 is optional WDM-PON overlay. Other technologies have their merits, but higher risk in 2015 time frame (target of FSAN NG-PON2). NG-PON uses expected for wireline and wireless backhaul, business . The future research directions are the following: low cost technologies within existing standards framework (components, systems); reduce operational cost; support multi-provider and multi-service (business, residential, backhaul); green access solutions (in CO and at CPE); and new long-term concepts beyond standards (needs compelling advantage over standard solution and at lower cost).
An empirical evaluation of auction-based task allocation in multi-robot teams

Task allocation is an important topic in multiagent and multi-robot teams. In recent years, there has been much research on the use of auction-based methods to provide a distributed approach to task allocation. Team members bid on tasks based on local information, and the allocation is based on these bids. The focus of prior work has been on optimal allocations and has established that auction-based methods perform well in comparison with optimal methods, with the advantage of scaling better. Here we take a different approach, comparing auction-based methods not on the optimality of the allocation, but on the efficient execution of the allocated tasks. This approach factors in aspects such as the utilisation of the team members and the degree to which they interfere with each others' progress, giving a fuller picture of the practical use of auction-based methods.
Genomic Comparison between a Virulent Type A1 Strain of Francisella tularensis and Its Attenuated O-Antigen Mutant

ABSTRACT We report the complete genome sequences of TI0902, a highly virulent type A1 strain, and TIGB03, a related, attenuated chemical mutant strain. Compared to the wild type, the mutant strain had 45 point mutations and a 75.9-kb duplicated region that had not been previously observed in Francisella species.
Genetic analysis of Indian subjects with clinical features of possible type IIa hypercholesterolemia

We performed genetic analysis in 55 patients with clinical features of possible type IIa hypercholesterolemia and 76 normolipemic healthy subjects for mutations and polymorphisms in the low‐density lipoprotein (LDL) receptor (LDLR), apolipoprotein B‐100 (APOB), apolipoprotein E (APOE), and hepatic lipase (LIPC) genes to elucidate the important genetic factors that can influence cholesterol levels in our population. None of the subjects showed mutations in part of exon 26 of the APOB gene, whereas two class 5 mutations were identified in exon 9 of the LDLR gene. First, an E387K mutation was observed in a Gujarati family in which both the parents were heterozygous for the mutation. Second, a L393R mutation was observed in a 38‐year‐old female. We found no correlation between LIPC −514C/T genotypes and cholesterol levels whereas the apoε4 allele frequency was significantly higher in cases and the apoE4 genotype was found to influence total cholesterol levels. J. Clin. Lab. Anal. 21:375–381, 2007. © 2007 Wiley‐Liss, Inc.
Efficient Error-Correcting Viterbi Parsing

The problem of error-correcting parsing (ECP) using an insertion-deletion-substitution error model and a finite state machine is examined. The Viterbi algorithm can be straightforwardly extended to perform ECP, though the resulting computational complexity can become prohibitive for many applications. We propose three approaches in order to achieve an efficient implementation of Viterbi-like ECP which are compatible with beam search acceleration techniques. Language processing and shape recognition experiments which assess the performance of the proposed algorithms are presented.
Effekte einer niedrigschwelligen ambulanten Adipositasbetreuung

Zusammenfassung Adipositas hat in der westlichen Welt bereits epidemieartige Ausmaße erreicht und zählt derzeit zu den zentralen Gesundheitsproblemen. Da es derzeit weder eine optimale Therapie der Adipositas im Kindes- und Jugendalter noch eindeutige Aussagen zu Erfolgsfaktoren einer Therapie gibt, sind wir der Frage nachgegangen, wie sich der Gewichtsverlauf bei einer niedrigschwelligen ambulanten Betreuung gestaltet und welche Prädiktoren es für eine erfolgreiche Teilnahme (Gewichtsstagnation oder -abnahme ausgedrückt in BMI-SDS) gibt. Das hier gewählte Betreuungskonzept ist typisch für Betreuungskonzepte in Deutschland. Eine Wirksamkeitsanalyse (Versorgungsforschung) solcher „Tägliche Praxis“-Vorgehensweisen existiert bisher nicht.
Mineral trioxide aggregate: a new material for endodontics.

BACKGROUND Mineral trioxide aggregate, or MTA, is a new material developed for endodontics that appears to be a significant improvement over other materials for procedures in bone. It is the first restorative material that consistently allows for the overgrowth of cementum, and it may facilitate the regeneration of the periodontal ligament. CASE DESCRIPTION The authors present five cases in which MTA was used to manage clinical problems. These included vertical root fracture, apexification, perforation repair and repair of a resorptive defect. In each case, MTA allowed bone healing and elimination of clinical symptoms. CLINICAL IMPLICATIONS Materials such as zinc oxide-eugenol cement and resin composite have been used in the past to repair root defects, but their use resulted in the formation of fibrous connective tissue adjacent to the bone. Because it allows the overgrowth of cementum and periodontal ligament, MTA may be an ideal material for certain endodontic procedures.
Regression Discontinuity Designs with Multiple Assignment Variables ∗ Yizhuang

In this paper, I extend current research on regression discontinuity (RD) designs with multiple assignment variables. I discuss the assumptions underlying the validity of such RD designs, and introduce graphical methods that check for violations of these assumptions. Instead of estimating a scalar treatment effect as in RD designs with a single assignment variable, I propose estimating treatment functions that are defined on the boundaries that separate different treatment groups in the assignment variable space. I generalize a local linear regression method currently used for estimation of said treatment functions, and separately develop a novel estimation method using thin plate regression splines. The performances of these estimation methods are assessed through an extensive simulation study based closely on real data.
Understanding the GeneRank Model

GeneRank is a new mathematical model in Bioinformatics, that is used in generating prioritized gene lists by exploiting biological background information. It is a modification of PageRank in the popular search engine Google. Using the matrix decomposition technique we find in this paper that there two dominant portions in the output of GeneRank. One is the information from the microarray data, and the other is the previous knowledge about the biological function of genes. The solution of the GeneRank can be approximated well by the linear combination of the two parts. Numerical results show the significance of the dominant parts. Thus the results of this paper give an understanding of GeneRank model.
Psychosocial Factors and Progression From Prehypertension to Hypertension or Coronary Heart Disease

PURPOSE This study explored the influence of trait anger and long-term psychological stress on progression to hypertension and incident coronary heart disease (CHD) in persons with prehypertension. METHODS A secondary data analysis was performed using the Atherosclerosis Risk in Communities (ARIC) study, a cohort of men and women aged 45 to 64 years at enrollment. Participants with blood pressures in the prehypertension range at the second visit conducted between 1990 and 1992, free of heart disease or stroke, and observed through the end of the ARIC study (1996–1998) were included (N = 2,334). The main outcomes were progression from prehypertension to hypertension and prehypertension to CHD or CHD death. RESULTS After adjusting for various covariates, high levels of trait anger, compared with low/moderate levels (odds ratio [OR] 1.53; 95% confidence interval [CI], 1.05–2.24), were associated with progression from prehypertension to hypertension. After stratifying on sex, trait anger was predictive for men only (OR 1.71; 95% CI 1.04–2.83). In survival analysis, trait anger was associated with progression to CHD for men (hazard ratio [HR] 1.92; 95% CI, 1.07–3.54). Long-term psychological stress was also associated with risk of incident CHD (HR 1.68; 95% CI 1.18–2.40). CONCLUSIONS High levels of trait anger in middle-aged prehypertensive men were associated with increased risk of progressing to hypertension and incident CHD. Long-term stress was also associated with increased risk of incident CHD in both men and women.
A Trajectory of Increasing Activity and the Elaboration of Chemosensory Modality: A New Perspective on Vertebrate Origins

Abstract This article reviews recent advances in comparative biological studies of vertebrate origins, with the aim of revisiting the long-standing controversy concerning these origins. Since early vertebrate evolution is paralleled by an evolutionary trend towards increasing activity, I focus on the evolution of respiratory and circulatory systems and discuss their potential roles in early vertebrate evolution. I give particular attention to the nasohypophyseal duct, an orifice characteristically found in agnathan vertebrates, and hypothesize that this duct originally functioned to convey oxygen dissolved in seawater to the respiratory gills. The chemosensory cell population that originated from the wall of the duct became the incipient olfactory organ and played a role in the organization of feeding behavior. An increase in chemosensory receptor genes via large-scale genomic evolution in the vertebrate lineage caused the repertoire of chemosensory cells to diversify and led to the appearance of the integrative center, including telencephalic structures typically lacking in protochordates.
Draft Genome Sequence of Deinococcus sp. Strain RL Isolated from Sediments of a Hot Water Spring

ABSTRACT Deinococcus sp. strain RL, a moderately thermophilic bacterium, was isolated from sediments of a hot water spring in Manikaran, India. Here, we report the draft genome (2.79 Mbp) of this strain, which contains 62 contigs and 2,614 coding DNA sequences, with an average G+C content of 69.4%.
Temporal analysis of blood–brain barrier disruption and cerebrospinal fluid matrix metalloproteinases in rhesus monkeys subjected to transient ischemic stroke

Blood–brain barrier (BBB) disruption plays an important role in pathophysiological progress of ischemic stroke. However, our knowledge of the dynamic change of BBB permeability and its mechanism remains limited. In the current study, we used a non-human primate (NHP) MCAO model and a serial CSF sampling method that allowed us to determine the dynamic change of BBB permeability by calculating the CSF/serum albumin ratio (AR). We showed that AR increased rapidly and significantly after ischemia, and the fold increase of AR is highly correlated with the infarction size during the subacute phase. Moreover, we determined the temporal change of MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-13, TIMP-1, and TIMP-2 in CSF and serum. Each MMP and TIMP showed different change patterns when comparing their values in CSF and serum. Based on the longitudinal dataset, we showed that the fold increase of MMP-9 in serum and CSF are both correlated to infarction size. Among the measured MMPs and TIMPs, only MMP-2, MMP-13, and TIMP-2 in CSF correlated with AR to some extent. Our data suggest there is no single MMP or TIMP fully responsible for BBB breakdown, which is regulated by a much more complicated signal network and further investigations of the mechanisms are needed.
Links between production and consumption of electricity with economic performance in Mexico

Understanding the causal directions between electricity consumption (EC)/electricity production (EP) and Gross Domestic Product (GDP) is helpful for policymakers in order to design, redesign, and implement effective energy policies. Although there are many studies on this issue, no consistent conclusion exists. In this paper, we provide an updated analysis of such relationship for Mexico. We employ three causality tests and find no evidence of causal relation between EC/EP and GDP between 1965 and 2014. This has implications for the Mexican energy legislation liberalizing the electricity generation sector. Our results suggest that Mexican policymakers should consider enriching the bill by further designing policies that seek to promote enhanced generation output and capacity.
Binding of steroid modulators to recombinant cytosolic domain from mouse P-glycoprotein in close proximity to the ATP site.

We recently found that recombinant NBD1 cytosolic domain corresponding to segment 395-581 of mouse mdr1 P-glycoprotein bound fluorescent 2'(3')-N-methylanthraniloyl-ATP (MANT-ATP) with high affinity [Dayan, G. , Baubichon-Cortay, H. , Jault, J.-M. , Cortay, J. -C. , Deléage, G. , & Di Pietro, A. (1996) J. Biol. Chem. 271, 11652-11658]. The present work shows that a longer 371-705 domain (extended-NBD1), including tryptophan-696 as an intrinsic probe, which bound MANT-ATP with identical affinity, also interacted with steroids known to modulate anticancer drug efflux from P-glycoprotein-positive multidrug-resistant cells. Progesterone, which is not transported, its hydrophobic derivatives medroxyprogesterone acetate and megestrol acetate, and Delta6-progesterone produced nearly a 50% saturating quenching of the domain intrinsic fluorescence, with dissociation constants ranging from 53 to 18 microM. The even more hydrophobic antiprogestin RU 486 produced a complete quenching of tryptophan-696 fluorescence, in contrast to more hydrophilic derivatives of progesterone containing hydroxyl groups at positions 11, 16, 17, and 21 and known to be transported, which produced very little quenching. A similar differential interaction was observed with full-length purified P-glycoprotein. The steroid-binding region within extended-NBD1 appeared distinct from the nucleotide-binding site as the RU 486-induced quenching was neither prevented nor reversed by high ATP concentrations. In contrast, MANT-ATP binding was efficiently prevented or displaced by RU 486, suggesting that the hydrophobic MANT group of the bound nucleotide analogue overlaps, at least partially, the adjacent steroid-binding region revealed by RU 486.
Promising Experimental Therapies for Metastatic Melanoma

Advanced melanoma has the highest per-death loss of years of potential life expectancy second only to adult leukemia. The incidence of melanoma continues to rise worldwide at approximately 3% per year, and in 2009 there were an estimated 68,720 new cases in the United States and 8650 deaths (Balch et al. 2009). According to Surveillance Epidemiology and End Results (SEER) data, roughly 4% of melanomas are metastatic at time of diagnosis. Locally advanced or recurrent unresectable, and disseminated melanoma is notoriously unresponsive to standard treatment, and is associated with a dismal prognosis. Patients with metastatic melanoma have a median survival of 8 months and 2-year survival rates of 10% to 15%. (Tsao et al. 2004). Until March of 2011, only 2 drugs were approved by the Food and Drug Administration (FDA) in the United States (US) for metastatic melanoma: interleukin 2 (IL-2) and dacarbazine (ipilimumab was approved in March of 2011 and will be discussed in this chapter). Dacarbazine is an alkalyting agent that in 1975 became the first chemotherapeutic drug approved by the US FDA for metastatic melanoma. Response rates for this regimen were 20% in a 30-year overview (Serrone et al. 2000), whereas more recent studies showed response rates in the 10-14% range (Bedikian et al. 2006; Chapman et al. 1999; Middleton et al. 2000). Temozolomide, an orally available congener of dacarbazine, was shown to be non-inferior in efficacy in comparison to dacarbazine in a randomized phase III trial (Middleton et al. 2000). Temozolomide had a similar objective response rate and overall survival compared to dacarbazine, and a significantly longer disease free survival. IL-2 was approved by the US FDA in 1998 for the treatment of metastatic melanoma. Single agent IL-2, when given in high dose intravenous boluses, leads to objective responses in 16% of patients, with complete responses in 6% and partial responses in 10%. Many patients maintained a complete response even after 7 years follow-up (Atkins et al. 2000). The toxicities of high dose IL-2 are substantial, including constitutional symptoms (fevers, chills, fatigue), hypotension, renal insufficiency, emesis, diarrhea and thrombocytopenia, and up to 2% of mortality is directly related to the treatment (Atkins et al. 2000). A systemic review of 41 randomized clinical trials including patients receiving various treatment schedules including biochemotherapy did not show improved progression-free survival (PFS) or overall survival (OS) (Eigentler et al. 2003). More recently, another meta-analysis of 18 trials involving nearly 2,500 patients with metastatic melanoma suggested an increase in response rate to biochemotherapy, but overall survival was not improved (Ives et al. 2007). Until today, biochemotherapy and combination chemotherapy built upon IL-2 and dacarbazine or temozolomide has not shown statistically
A CULTURA ORGANIZACIONAL VISTA COMO UM VEÍCULO DA ALIENAÇÃO E DO INSTRUMENTALISMO: UMA ANÁLISE SOB A LUZ DA TEORIA INSTITUCIONAL

RESUMO: As consequencias das acoes das organizacoes na sociedade sao um aspecto que deve ser sempre verificado pelas diversas ramificacoes das ciencias sociais. Um desses aspectos mais relevantes, a Cultura Organizacional, e analisada neste ensaio sob a luz da Teoria Institucional. O artigo aborda os aspectos alienantes das acoes empresariais e que fazem com que o instrumentalismo rompa as fronteiras da empresa e dissemine-se pela sociedade, fortalecendo a cultura do individualismo. Conclui que aspectos como o discurso da ideologia gerencial e a falta de rigor cientifico das teorias organizacionais da corrente da cultura de empresa atuam como legitimadores da acao empresarial e como fatores alienantes e de propagacao do instrumentalismo na sociedade. Palavras-chave: Cultura Organizacional. Alienacao. Instrumentalismo. Teoria Institucional.
Predictors of colorectal screening in rural Colorado: testing to prevent colon cancer in the high plains research network.

CONTEXT Colorectal cancer is the second leading cause of cancer death in the United States, yet screening rates are well below target levels. Rural communities may face common and unique barriers to health care, particularly preventive health care. PURPOSE To establish baseline attitudinal, knowledge, belief, and behavior measures on colorectal cancer screening and to identify barriers to or predictors of colorectal cancer screening. METHODS As part of a controlled trial using a quasi-experimental, pretest, post-test design, we conducted a baseline telephone survey of 1,050 rural eastern Colorado residents aged 50 years and older. Smaller counties were over-sampled to ensure a minimum of 30 completed interviews per county. FINDINGS Seventy-seven percent reported they ever had a colorectal cancer screening test and 59% were up-to-date on at least 1 test. The most important independent predictors of being up-to-date were having visited a doctor or other health care practitioner for a checkup in the past year, having personal or family history of colon polyps or cancer, and having asked for a colorectal cancer screening test. Financial concerns were reported reasons for not obtaining fecal occult blood testing by 18% and colonoscopy by 21%. CONCLUSIONS This study suggests that health care providers should be vigilant in counseling their patients 50 and older to have a colorectal cancer test. Community programs designed to promote colon cancer screening should encourage residents to have regular contact with their primary care physician and ask their doctor for a screening test. Additionally, programs should provide financial assistance for testing for low-income and uninsured patients.