Miracle-dz/UniFAR-FTUs huggingface dataset:
Unmet Medical Needs in Glioblastoma Management and Optimal Sequencing of the Emerging Treatment Options

The standard treatment for patients with newly-diagnosed glioblastoma multiforme includes microsurgical tumor resection, external beam radiation in combination with temozolomide (TMZ) chemotherapy, and then adjuvant chemotherapy with TMZ alone. In addition, there are new drugs targeting different key players in tumorigenesis and angiogenesis in malignant gliomas that are currently being tested in clinical trials. Thus, more sophisticated molecular and genetic profiling will be necessary to determine which patients are most likely to benefit from the specific treatment options. In cases of unavoidable tumor recurrence, no clear standard of therapy exists, and there is no expert consensus on how to treat these patients. Re-resection, re-radiation, or changes in chemotherapeutic schedule or drug are general options, but each has to be considered on a case-by-case basis. In addition, institutions often have some mostly experimental local or systemic approaches that are considered in recurrent glioblastomas. This has led to growing uncertainty as to how to treat patients with glioblastomas and recurrent disease and when to use which therapeutic option. Decision-making also depends on the time point of therapy onset, and therefore also the correct detection of real tumor progression. Magnetic resonance imaging (MRI) has been demonstrated to have diagnostic limitations in cases of ‘‘pseudoprogression’’ after multimodal therapy and in patients treated with antiangiogenic drugs. Thus, new imaging techniques such as MR spectroscopy, MR FLAIR sequences, ADC maps, and nuclear medicine imaging with O-(2-[F]fluoroethyl)-L-tyrosine positron emission tomography (FET-PET) or other tracers will be of almost as much importance in the treatment of glioblastoma as the different tumor therapies in due time.
Information and Communication Technologies and Family: Patterns of Use, Life Cycle and Family Dynamics

Information and Communication Technologies (ICTs) broadly designate hardware devices (e.g., computers, smartphones, webcams) as well as software and applications used on these devices (e.g., email, videoconferencing, online social networks) which underpin digital culture [1,2]. Given the exponential growth in the use of these resources over the last two decades, ICTs nowadays represent an integrative part of contemporary family life [2,3]. According to Eurostat’s last publication [4], 81% of European households had computers with internet access in 2014. This is particularly true for 93% of the households in Norway, 90% in the U.K., 74% in Spain and 65% in Portugal. Regarding the USA, 87% of adults used the internet in 2014 [5]. More recent data indicate that 92% American adults have a cell phone, 68% have a smartphone and 45% have a tablet computer in 2015 [6].
Dementia: international comparisons

Taking England as the reference, and looking at a number of other high-income countries, comparisons have been made in relation to: demography; attitudes towards dementia; approaches to diagnosis of dementia; funding arrangements and availability; range and balance of services (including long-term care and nursing home provision), interventions and therapies; role of informal care givers; role of voluntary sector and government services; programmes/services in place especially for older people.
René Kager, Joe Pater and Wim Zonneveld (2004). Constraints in phonological acquisition. Cambridge: Cambridge University Press. Pp. ix+417.

After several years of being cited as in press, the long-anticipated volume Constraints in phonological acquisition, edited by René Kager, Joe Pater andWim Zonneveld, finally appeared in spring 2004. * This is the first edited volume to be published that is devoted exclusively to phonological acquisition from the perspective of Optimality Theory. The volume includes important contributions from some of the leading figures in Optimality Theory and/or phonological acquisition. Descriptive, experimental and computational studies relating to typical first-language acquisition and foreign-word adaptation are included. The volume is unparalleled in these respects, and should serve as essential reading for researchers and students interested in phonological acquisition or Optimality Theory. In fact, the volume has already achieved considerable success, as evidenced by its many citations in the work of others. Naturally, as with any volume, some shortcomings are also expected, and this volume has its share. On balance, however, the strengths of the volume certainly outweigh its weaknesses. My review begins with a brief critique of each of the eleven chapters and then turns to a consideration of the volume’s shortcomings. In fairness to all, it is important to keep in mind that there was a rather considerable lag between the times when the volume was conceived and ultimately published. Several of the chapters were drawn from a 1998 workshop on phonological acquisition held in Utrecht. Additionally, some of the work appeared in one form or another dating as far back as 1994. As a result, much of the volume reflects acquisition research that was conducted in the early stages of Optimality Theory. This review will thus attempt to fill in some of the gaps by identifying current challenges and relevant work.
Percutaneous Repair for Recurrent Mitral Regurgitation After Surgical Repair: A Mitraclip Experience

ABSTRACT Background: The aim of our study was to evaluate the acute feasibility and short-term efficacy of mitral valve repair using the MitraClip device in patients with prior surgical repair. Mitral regurgitation (MR) may recur after surgical repair. Because reoperation is associated with significant mortality and morbidity, a transcatheter approach appears appealing. Methods: Between April 2015 and December 2016, 12 patients with MR after a previous surgical repair underwent the MitraClip procedure. Procedural details, intraoperative echocardiographic features, and baseline and 30-day clinical follow-up data were analyzed and compared to those of patients undergoing MitraClip therapy with no prior surgical repair (n = 54) within the same timeframe. Results: Past medical history, MR severity, and NYHA class did not differ between the two groups. A MitraClip was deployed in all 12 patients in the surgical repair (SR) group and in 51 patients in the no surgical repair (NR) group. Induction of mitral stenosis precluding final device deployment occurred in one and two cases, respectively. The procedure was associated with successful reduction of MR to ≤ moderate in all SR patients and in 47 (96%) NR patients. Total procedural time, fluoroscopy time, time from transseptal access to first MitraClip release, and final diastolic gradients were not different between the groups. Clinical outcomes—NYHA class and KCCQ scores—were not different at 30 days. Conclusions: In selected patients with recurrent MR after surgical repair, the MitraClip procedure is feasible and effective without significant increase in procedural time, fluoroscopy time, diastolic mitral gradient compared to MitraClip therapy in patients without prior surgical repair.
Macro-data: a new approach for the development of tele-expertise applications

The aim of this paper is to present new methods for tele-expertise applications design, based on an original concept of macro-data representation, modeling and management. A macro-data is an aggregation of several data types, including signals and images, their semantic and syntactic representation, as well as the syntax of their presentation. It may encapsulate existing standards like RTF, SCP-ECG and DICOM, and may be represented using the XML language for electronic data interchange. The macro-data model-based design facilitates and speeds-up the filling of the patient records, and allows to presence data presentation at the target site. Using the UML notation, we present a complete software architecture model integrating user-specific macro-data models management. The result is the development of an application, based on generic object components, called "Expert-Assist".
Software component reliability analysis

This paper describes an approach to analyzing software reliability using component analysis. It walks through a 6-step procedure for performing software component reliability analysis. The analysis can begin prior to testing the software and can help in selecting testing strategies. It uses the Extended Execution Time (EET) reliability growth model at the software component level. The paper describes how to estimate model parameters from characteristics of the software components and characteristics of how test cases and operational usage stress the software components. The order in which test cases are run is used in combining component models to arrive at a composite reliability growth model of the software for the testing period. The paper walks through an example illustrating the effects on reliability growth of: selecting test cases based on an operational profile versus selecting them based on uniform coverage of test cases; and incremental delivery of software components to system test. The paper contrasts the described approach to other approaches currently used to analyze software reliability growth during testing. The analysis can be done using commercial data analysis programs.
İŞYERİNDE SANAL TEMBELLİK DAVRANIŞI VE ETKİN ZAMAN YÖNETİMİ İLİŞKİSİ: BİR KAMU KURUMUNDA ARAŞTIRMA

Zaman yonetimi gunumuz isletmelerindeki en buyuk rekabet silahlarindan birisidir. Orgutun zamanindan alikonulan bir dakika bile buyuk onem tasimaktadir. Teknolojinin yayginlasmasi ile beraber internet, bilgisayarlar ve akilli telefonlar insan hayatinin her anini isgal eder hale gelmistir. Internet ve bilgisayar teknolojileri is yapma yontemlerini pratiklestirerek ve kisaltarak isletmeler icin vazgecilmez bir is gorme vasitasi haline gelmistir. Ancak internet yararlarinin yani sira bircok sorunu da beraberinde getirmektedir. Isgorenlerin interneti mesai saatleri icinde is disi amaclarla kullanmalari gunumuzde sik karsilasilan bir durum haline gelmistir. Literaturde sanal tembellik adi verilen bu davranis isletmelerde zaman, maliyet ve verimlilik kayiplarina neden olmakta, isletmeyi cesitli yasal yaptirimlarla karsi karsiya birakabilmektedir. Bu calismanin amaci, isyerinde sanal tembellik davranisi ve etkin zaman yonetimi arasindaki iliskiyi ortaya koymaktir. Arastirma sonucunda, zaman yonetimi olceginin alt boyutu olan zaman tuzaklarinin sanal tembellik davranisini pozitif yonde etkiledigi tespit edilmistir.
The intra-and inter-day reproducibility of the FitroDyne as a measure of multi-jointed muscle function.

Reprinted from Isokinetics and Exercise Science, Vol 24, Fernandes, J., Lamb, K. , & Twist, C. , The intra- and inter-day reliability of the FitroDyne as a measure of multi-jointed muscle function, pp. 39-49, Copyright (2016), with permission from IOS Press
Estudo do estado de diferenciao da clula mioepitelial nas neoplasias de glndula salivar

Study of the myoepithelial cell differentiation state in salivary gland tumors. The myoepithelial cell (MC) in salivary gland tumors is presented at different stages of differentiation. The cell presents specific muscles actin (SMA) and Citokeratin (CK)14 in normal gland. On the other hand, there is a participation of extracellular matrix components, as the laminin (LN), in the morphogenesis and cito differentiation of the glands structures. Considering that, we decided to study the different stages of the MC differentiation through SMA expression, the CK 14, as well as the LN participation in this process. Tumors which present the MC participation were used: pleomorphic adenoma, myoepithelioma, adenoma of basal cells, adenoid cystic carcinoma. The immunohistochemical of avidine-biotine analysis of the specimens was done. Results showed that the presence of SMA was rare, as well as the presence of CK 14 that was only noticed on the well formed ductiforms structures. On the other hand, LN was presented adjacent to the MC, independently on the expression of CK 14 and SMA, and in the strom of the differentiated and indifferentiated tumors. Results show that it is possible to identify different stages of myoepithelial differentiation through CK 14 and SMA expression, but it seems there is not a correlation between the LN and the MC tumor differentiation, considering that the MC tumor differentiation keeps secreting LN, even if defectively after oncogenic stimulus.
Use and diversion of illicit methadone – under what circumstances does it occur, and potential risks associated with continued use of other substances

Background: Concerns about prescribed methadone diversion are ongoing. This research investigated motivations for methadone diversion and continued use of street-sourced substances. Methods: Questionnaires completed with 886 past year users of methadone recruited in and out of prescribing agencies. Topics covered included current prescribing, obtaining/providing methadone, reasons for using illicit methadone and other substance use. Results: Missing appointments (prescription pick-up or reviews) were the most common reasons for use of diverted methadone but the most common course of action in these circumstances was to use other street-sourced substances. Topping up dosage levels was also a common reason for obtaining illicit methadone. The most common reason diverting methadone was to “help another substance user out”. Concurrent and simultaneous use of a variety of substances whilst prescribed methadone was common. Conclusion: Reasons for using diverted methadone are primarily related to service use and provision. Treatment services will need to consider their role in reducing demand for diverted methadone. Unlike previous work the diversion of prescribed methadone appears to be most often motivated by altruism. Simultaneous and concurrent polysubstance use increases health risks, and with the extent of these risks not fully understood, individuals are “gambling” with their usage patterns.
Automatic quantification of retinal photoreceptor integrity to predict persistent disease activity in neovascular age-related macular degeneration using deep learning

Purpose Using deep learning (DL)-based technique, we identify risk factors and create a prediction model for refractory neovascular age-related macular degeneration (nAMD) characterized by persistent disease activity (PDA) in spectral domain optical coherence tomography (SD-OCT) images. Materials and methods A total of 671 typical B-scans were collected from 186 eyes of 186 patients with nAMD. Spectral domain optical coherence tomography images were analyzed using a classification convolutional neural network (CNN) and a fully convolutional network (FCN) algorithm to extract six features involved in nAMD, including ellipsoid zone (EZ), external limiting membrane (ELM), intraretinal fluid (IRF), subretinal fluid (SRF), pigment epithelium detachment (PED), and subretinal hyperreflective material (SHRM). Random forest models were probed to predict 1-year disease activity (stable, PDA, and cured) based on the quantitative features computed from automated segmentation and evaluated with cross-validation. Results The algorithm to segment six SD-OCT features achieved the mean accuracy of 0.930 (95% CI: 0.916–0.943), dice coefficients of 0.873 (95% CI: 0.847–0.899), a sensitivity of 0.873 (95% CI: 0.844–0.910), and a specificity of 0.922 (95% CI: 0.905–0.940). The six-metric model including EZ and ELM achieved the optimal performance to predict 1-year disease activity, with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.980, the accuracy of 0.930, the sensitivity of 0.920, and the specificity of 0.962. The integrity of EZ and ELM significantly improved the performance of the six-metric model than that of the four-metric model. Conclusion The prediction model reveals the potential to predict PDA in nAMD eyes. The integrity of EZ and ELM constituted the strongest predictive factor for PDA in nAMD eyes in real-world clinical practice. The results of this study are a significant step toward image-guided prediction of long-term disease activity in the management of nAMD and highlight the importance of the automatic identification of photoreceptor layers.
A systematic review of research on discharge summaries in Europe

Background The hospital discharge summary, a succinct resume of a specific episode of care, is a highly relevant health record to support continuity of care of a patient moving between providers, levels of care and across national borders. This is particularly relevant in light of the recently adopted Directive 2011/24 on the application of patients' rights in cross-border healthcare. Methods …
Cranial manipulation : theory and practice : osseous and soft tissue approaches

1. A brief historical perspective. 2. Cranial fundamentals revisited. Exercises: refining cranial palpation skills 3. Integration with medicine - the scope of cranial work 4. The biodynamic model of osteopathy in the cranial field. 5. Chiropractic in the cranial field. 6. Cranial movement: mechanical and subtle 7. Cranial bones: assessment and manipulation. 8. Cranial implications of muscular and fascial distress. 9. Assessment and treatment of key cranially associated muscles 10. Positional release and cranial pain and dysfunction. 11. Cranial therapy and dentistry. 12. Clinical applications of cranial manipulation Appendix 1. Soft tissue manipulation fundamentals Appendix 2. Cranial treatment and the infant. Index
Model Based Energy Management and State Estimation for the Robotic Electric Vehicle ROboMObil

An innovative energy management framework – focusing on the spatial vehicle motion – is developed and evaluated by simulations with realistic test scenarios using a multiphysical Modelica model of ROboMObil. Additionally, a novel method is proposed, and evaluated with ROboMObil, to automatically construct real-time capable, discrete-time, nonlinear state estimation algorithms with constraint handling from multi-physical, continuous-time Modelica models.
Internationalizing the Business Program—A Perspective of a Small School

Abstract The internationalization of the business curriculum is a strategic change that business schools must embrace if they are to prepare students for careers in a global business environment. Various approaches to internationalization exist, but they depend on the availability of resources, administrative commitment, and the level of internationalization that the school wants to achieve. In this article, the authors review various aspects of internationalizing a business program and describe the experience of a small private college.
Langzeitergebnisse und Analysen von Zusammenhängen 5 Jahre nach Varizenstripping

Zusammenfassung Ziel: Überprüfung der Rezidivquote und -einteilung sowie Analyse weiterer Zusammenhänge. Patienten, Methode: 5 Jahre postoperativ wurden bei 93 Patienten 131 operierte Krossen (inguinal: 117, popliteal: 14) klinisch sowie doppler- und duplexsonographisch nachuntersucht (Quote: 48 %). Die Befunde wurden in 4 Gruppen eingeteilt: 1) Krossenrezidive mit Indikation zur Rekrossektomie, 2) operationsbedürftige Befunde ohne Indikation zur Rekrossektomie, 3) Rezidivvarikosis ohne klinische Relevanz und 4) keine Rezidivvarikosis. Aktuelle Beschwerden, Nebendiagnosen und klinische Einteilungen wurden dokumentiert. Ergebnisse: 8.5 % der Patienten wiesen inguinale, 28,6 % popliteale Rezidive auf (in Bezug auf die jeweils operierten Krossen. Gesamt: 10,7 %). 11,5 % der Patienten wurden Gruppe 2 zugeordnet, 77,8 % Gruppe 3 und 4. In den Analysen der Zusammenhänge fanden sich signifikante Unterschiede zwischen Beschwerdesymptomatik und Nachuntersuchungsbefund sowie BMI und Nachuntersuchungsbefund. Schlussfolgerungen: Trotz korrekter Krossektomie finden sich operationsbedürftige Krossenrezidive. Adipöse Patienten entwickeln diese signifikant häufiger. Die Indikation zur operativen Sanierung einer Insuffizienz der Vena saphena parva (VSP) sollte aufgrund höherer Rezidivquoten eher zurückhaltend gestellt werden. Die gewählte Rezidiveinteilung erweist sich als sinnvoll.
Response to concurrent cetuximab: radiotherapy following failure of platinum-based induction chemotherapy in squamous cell carcinoma of the larynx

Abstract Concurrent chemoradiation is the standard of care in the non-surgical management of locally advanced squamous cell carcinoma (SCC) of the larynx. Cetuximab can be used as an alternative to platinum for concomitant radiotherapy and the addition of cetuximab to cisplatin has been reported to improve response rates compared with cisplatin alone. We report two cases of patients who progressed through platinum-based induction chemotherapy and subsequently achieved a complete response with concurrent cetuximab radiotherapy.
PREVALENCE OF OBESITY IN 12–14 YEAR OLD CHILDREN IN ZANJAN, IRAN AND SOME RELATED FACTORS

Background and purpose: Obesity in childhood can cause obesity and its associated health problems in adulthood. This study aimed at determining the prevalence of obesity and some related factors in high school male and female adolescents in Zanjan, Iran. Materials and methods: This cross-sectional study was conducted in 1366 adolescents aged 12 to14 years who were randomly recruited from high schools in Zanjan, 2013. The weight, height and the body mass index (BMI) of all participants were measured. A researcher made questionnaire was used to record information including birth history, feeding pattern, family history of obesity, and sleeping and activity times. Results: The participants included 57.1% (n=780) females. Among the girls and boys 4.5% and 3.1% were found to be obese, respectively. The prevalence of overweight and obesity was 12.2% and 3.9%, respectively. There was a significant relationship between obesity and birth weight, formula or breastmilk feeding, time of starting solid foods, family history of obesity, physical activity, time spent watching TV, taking snacks, and having rice during a week (P< 0.05). Conclusion: High prevalence of obesity and overweight among adolescents in Zanjan calls for efficient programs to prevent childhood obesity. Therefore, families should be provided with necessary information about healthy lifestyle and nutrition.
Caractérisation des mécanismes naturels de vieillissement de lambris de bâtiments en bois

Nowadays, it is not common knowledge to know when it is appropriate to reapply a new coating. The aim of this study was to find an indicator to monitor the coating state. Different wood opaque paints have undergone weathering in both Florida and Arizona. The results confirm the necessity to have a tailor-made solution for monitoring the coating state. The characterization of the wood beneath the coating has been done with an ATR-FTIR. The monitoring of both the lignin and the cellulose crystallinity has been realized. It appeared that the lignin seems to indicate an early loss of performance of the coating protective layer. However some limits exist in the experimental design and further experiment should be processing.
Pushing HiiMap into the Kernel: An easy-to-use Implementation of a real Locator/Identifier-Split

While the Internet in its current form delivers a wide variety of services to its users, the underlying architecture is facing more and more problems, which might inhibit its future success. Among several ideas of improvement, the so-called locator/identifier-split is the most promising. However, practically using a locator/identifier-split for testing purposes is quite complicated, as its whole functionality is not provided in current systems and has to be realized by the user in the application layer. In this work we present an implementation of the HiiMap locator/identifier-split protocol in the Linux kernel and evaluate it in the G-Lab testbed. This implementation provides a programming interface for applications that is as easy as opening a standard Internet socket. All features of the locator/identifier split are handled by that module. Furthermore, mobility and network interface changes are fully supported by the kernel module.