Miracle-dz/UniFAR-FTUs huggingface dataset:
The sintering densification and microstructure evolutions of Ti-1Al-8V-5Fe alloy with Si additions

ABSTRACT The cost-efficient Ti-1Al-8V-5Fe-xSi (denoted Ti-185-xSi hereafter, x = 0, 0.15, 0.3, 0.45, 0.6, 0.75) alloys are synthesized by cold compaction and sintering powder metallurgy (PM) technology using TiH2 and high-pure FeV80 powders. The sintering densification, microstructural evolutions and mechanical behavior of Ti-185-xSi alloys sintered at 1350°C are investigated. The results show that the Si element is favorable to enhance the sintered density of Ti-185 alloys, which should be limited to ≤0.3%. The amount and average size of precipitate Ti5Si3 increase in the Ti-185 alloys with increasing Si content. Meanwhile, the Rockwell hardness of Ti-185 alloy also displays an increasing tendency, suggesting the Si element can improve the hardness of Ti-185. The Ti-185–0.15Si alloy possesses a better comprehensive mechanical property of strength (937 ± 8 MPa) and elongation (3.5%). The high-performance Ti-185 alloy is successfully prepared using low-cost FeV80 master alloy with slight Si impurity instead of costly V.
miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.

BACKGROUND Oral squamous cell carcinoma (OSCC) is an important malignant disease around the world. Aberrant expression of MicroRNAs (miRNAs) has been implicated in carcinogenesis of various cancers. In previous studies, up-regulation of miR-181 was observed when OSCC progressed from leukoplakia, dysplasia to invasive carcinoma. However, the function of miR-181 in oral tumorigenesis remains unclear. MATERIALS AND METHODS The expression levels of miR-181 in the tissue and plasma of OSCC patients were measured by quantitative RT-PCR. The correlation between miR-181 level and multiple clinical variables were then checked by Mann-Whitney test and Wilcoxon matched pairs test. To study the functional meaning of up-regulated miR-181, migration assay and invasion assay by transwells and colony forming assay were applied to analyze the tumorigenic phenotypes of OSCC cells with ectopical expression of miR-181. RESULTS Among different clinical variables, over-expression of miR-181 was correlated with lymph-node metastasis, vascular invasion, and a poor survival. Functional assays revealed ectopically over-expressed miR-181 would enhance cell migration and invasion, but not the ability of anchorage-independent growth of OSCC cells. In addition, the up-regulation of miR-181 could be detected both in tumor tissues and plasma. CONCLUSION miR-181 may enhance lymph-node metastasis through regulating migration, which could potentially be exploited as a putative biomarker for patients with OSCC.
Deep Brain Stimulation of the Internal Globus Pallidus for Generalized Dystonia Associated with Spinocerebellar Ataxia Type 1: A Case Report

Ataxia is a common movement disorder aﬀecting primarilybalance and coordination. The cerebellar circuitry is most com-monlyinvolved,buttherecanalsobeinvolvementofconnectedstructures, including the thalamus, globus pallidus, and striatum(1,2). Thereisasubsetofataxicsyndromesthatareinheritedinanautosomaldominantfashion.Spinocerebellarataxiatype1(SCA1)isaninheritedformofataxiaassociatedwithabnormalCAGrepeatson the ataxin 1 gene on chromosome 6 (3). The highly variableclinical features of this disorder are well documented and mayinclude dystonia, parkinsonism, cognitive dysfunction, and othermovementdisordersinadditiontoataxia(1,4). Deepbrainstimula-tion(DBS)oftheglobuspallidusinternus(GPi)hasbeenestablishedasatreatmentforgeneralizeddystonia.Recentimagingtechniques,suchasdiﬀusiontensorimaging(DTI),provideaninvivoestimationoftheanatomicaltractsaﬀectedbyDBS(5). WepresentacaseofgeneralizeddystoniainapatientwithgeneticallyconﬁrmedSCA1whorespondedwelltobilateraldeepbrainstimulationoftheGPi.
Should we be looking for and treating isolated calf vein thrombosis?

Management of isolated calf deep vein thrombosis is an area of significant international debate and variable clinical practice. Both therapeutic anticoagulation and conservative management carry risk. As clinical care of suspected and confirmed venous thromboembolic disease increasingly becomes the remit of emergency medicine, complex decisions are left to practising clinicians at the front door. We aim to provide a contemporary overview of recent evidence on this topic and associated challenges facing clinicians. Given the lack of high-level evidence, we present this work as a narrative review, based on structured literature review and expert opinion. A decision to manage calf thrombosis is principally dependent on the risk of complications without treatment balanced against the risks of therapeutic anticoagulation. Estimates of the former risks taken from systematic review, meta-analysis, observational cohort and recent pilot trial evidence include proximal propagation 7%–10%, pulmonary embolism 2%–3% and death <1%. Fatal bleeding with therapeutic anticoagulation stands at <0.5%, and major bleeding at approximately 2%. Estimates of haemorrhagic risk are based on robust data from large prospective management studies of venous thromboembolic disease; the risks of untreated calf deep vein thrombosis are based on small cohorts and therefore less exact. Pending further trial evidence, these risks should be discussed with patients openly, in the context of personal preference and shared decision-making. Anticoagulation may maximally benefit those patients with extensive and/or symptomatic disease or those with higher risk for complication (unprovoked, cancer-associated or pregnancy).
Long term survival after trimodal therapy in malignant pleural mesothelioma.

PRINCIPLES Trimodal therapy results in long term survival in a small fraction of patients with malignant pleural mesothelioma, particularly in patients having epithelial histology, R0-resection and no nodal involvement. This study analyses the outcome after trimodal therapy including extrapleural pneumonectomy. METHODS From 2000 to 2005 41 patients with histologically verified malignant pleural mesothelioma were included. Diagnosis and nodal status were confirmed by surgery. 21 patients (51%) underwent trimodal therapy with 655 days (63-2,567 days) of median follow-up. Postoperative complications, mortality, long term survival and recurrence rates were analysed retrospectively. RESULTS Neoadjuvant chemotherapy consisted of a combination of platinum based agents (n = 19) with gemcitabine (n = 15) or pemetrexed (n = 4). Extrapleural pneumonectomy was the standard procedure for surgery. 13 patients (62%) had postoperative complications. 16 patients (76%) received postoperative adjuvant radiotherapy. There was a 30-day mortality of 4.8% in the trimodal group. Survival rates in the trimodal group were 71% after one, 28% after two and 10% after five years. There were no significant differences regarding age, tumour stage, cell type or lymph node involvement. Tumour recurrence occurred after one and two years in 44% and in 83% respectively. CONCLUSIONS The majority of patients considered for surgical resection of malignant pleural mesothelioma have regionally advanced disease. In those receiving trimodal therapy long term survival is achieved only in a minority of patients. In view of the time consuming and intensive treatment it should be offered only in carefully selected patients as new surgical approaches such as pleurectomy/decortication have shown high efficacy rates regarding patients' survival.
Consejeria en alimentación, actividad fÍsica y tabaco: Instrumento fundamental en la practica profesional

El objetivo de este articulo es presentar una actualizacion de los fundamentos teoricos y metodologicos de la consejeria y la evidencia sobre su eficacia, relacionandola con la practica de los equipos de salud y analizando los desafios futuros. Se describen las bases teoricas, las orientaciones de politica del Ministerio de Salud de Chile, las estrategias recomendadas a nivel internacional y los aportes de los participantes de un programa de capacitacion realizado por el INTA con 312 profesionales (nutricionistas, kinesiologos y odontologos en su mayoria). Se presenta el analisis de las condiciones en la Atencion Primaria de Salud para implementar la consejeria en alimentacion, actividad fisica y tabaco en forma sistematica. Se discute la necesidad de adoptar medidas para el mejoramiento de la practica y su contribucion a un abordaje preventivo de los graves problemas de sedentarismo, obesidad y tabaquismo en la poblacion chilena.
Measurement of the Physical Properties of Aerosols in a Fullerene Factory for Inhalation Exposure Assessment

Assessment of human exposure is important for the elucidation of potential health risks. However, there is little information available on particle number concentrations and number size distributions, including those of nanoparticles, in the working environments of factories producing engineered nanomaterials. The authors used a scanning mobility particle sizer and an optical particle counter to measure the particle number size distributions of particles ranging in diameter (D p ) from 10 nm to >5000 nm in a fullerene factory and used scanning electron microscopy to examine the morphology of the particles. Comparisons of particle size distributions and morphology during non-work periods, during work periods, during an agitation process, and in the nearby outdoor air were conducted to identify the sources of the particles and to determine their physical properties. A modal diameter of 25 nm was found in the working area during the non-work period; this result was probably influenced by ingress of outdoor air. During the removal of fullerenes from a storage tank for bagging and/or weighing, the particle number concentration at D p <50 nm was no greater than that in the non-work period, but the concentration at D p >1000 nm was greater during the non-work period. When a vacuum cleaner was in use, the particle number concentration at D p <50 nm was greater than that during the non-work period, but the concentration at D p >1000 nm was no greater. Scanning electron microscopy revealed that the coarse particles emitted during bagging and/or weighing were aggregates/agglomerates of fullerenes; although origin of particles with D p <50 nm is unclear.
Oscillations in exchange coupling and magnetoresistance in metallic superlattice structures: Co/Ru, Co/Cr, and Fe/Cr.

Mise en evidence d'une interaction d'echange intercouche antiferromagnetique et d'une magnetoconductivite en saturation dans les superreseaux Co/Cr et Co/Ru. La magnetoconductivite et l'interaction d'echange oscille avec l'epaisseur des couches
Caveolin-associated Filamentous Actin (Cav-actin) Defines a Novel F-actin Structure in Adipocytes*

Dynamic actin remodeling has been implicated in the translocation of the insulin-responsive glucose transporter 4 (GLUT4) to the plasma membrane in adipocytes. Here we show that fully differentiated 3T3L1 adipocytes have unique cortical filamentous actin structure, designated Cav-actin (caveolae-associated F-actin). During 3T3L1 adipocyte differentiation, rhodamine-phalloidin staining demonstrated the formation of a cortical actin cytoskeleton that is composed of small dot-like F-actin spikes lining the inside of the plasma membrane. Double labeling with a caveolin antibody indicated that these F-actin spikes emanate from organized rosette-like clusters of caveolae/lipid raft microdomains. In contrast, there was no obvious relationship between F-actin and caveolin localization and/or organization in 3T3L1 preadipocytes (fibroblasts). Treatments of differentiated adipocytes with latrunculin B, Clostridium difficile toxin B or a dominant-interfering TC10 mutant (TC10/T31N) disrupted the Cav-actin structure without significantly affecting the organization of clustered caveolae. Similarly, disruption of the clustered caveolae with methyl-β-cyclodextrin also dispersed the Cav-actin structure. These data demonstrate that this novel Cav-actin structure is organized through clustered caveolae but that the formation of caveolae-rosettes are not dependent upon F-actin.
An analytic algorithm based position and orientation detection using a tri-axial magnetoresistive sensor

In this paper, a novel electromagnetic tracking system for detecting two-dimentional (2D) position and 1D orientation is proposed. This system utilizes the geomagnetic field and the magnetic field generated by the 2.5 kHz alternating signal from a uniaxial source coil. By extracting amplitudes, phases, and direct current component from the outputs of a triaxial magnetoresistive sensor, the tracking parameters of the sensor can be calculated by explicit analytical equations. Since the algorithm implmentation is based on analytic equations, this method is much simpler, faster, and more applicable than other tracking methods. The experimental results show that the method works satisfactorily with good accuracy when working in the space of 100mm × 120mm, which the root mean square position error is 2.0mm and the mean orientation error is 0.7° while the mean absolute position error is 1.9mm and the absolute orientation error is 0.6°.
Generalised Complementarity Analysis: identifying the most precious places for the conservation of Species, Functional and Phylogenetic Diversity

The most precious places for conservation are those that make the largest contribution to regional, national or global biodiversity. The two key concepts for determining the contribution of a specific site are Complementarity (the gain in diversity achieved when adding that site to a set of other sites) and Irreplaceability (here defined as the overall complementarity of that site when compared to a range of possible combinations of other sites). Generalised Complementarity Analysis (GCA) is a mathematical framework that provides an exact analytical solution for the expected complementarity (gain in diversity) of a focal site, when added to a set of other sites of a given size (m). Diversity is defined very generally to allow for complementarity to be calculated for species richness, Functional Diversity or Phylogenetic Diversity. The expected irreplaceability of a focal site is then defined in GCA as the area under the curve of expected complementarity values for all possible values of m. GCA is much more computationally efficient than existing algorithmic approaches and is scalable to very large numbers of sites. Because complementarity and irreplaceability are calculated for all possible combinations of sites, GCA serves as a null model for systematic conservation planning algorithms that seek to optimise site selection. However, because truly irreplaceable sites remain so under all possible site selections, GCA is a powerful conservation planning tool in its own right, providing an efficient means of identifying the world’s most precious places for conservation.
Hybrid Distance Field Computation for Volumetric Datasets (ST)

Distance fields are a widely investigated area within the area of Volume Graphics. Research is divided between applications; such as — skeletonisation, hypertexture, voxelisation, acceleration of rendering techniques, correlation and collision detection; and the fundamental algorithmic calculation of the distance fields. This paper concentrates on the latter by presenting a new method for calculating distance fields and comparing it with the current best approximate method and the true Euclidean distance field. Details are given of the algorithm, and the acceleration methods that are used for calculating the true distance field. Brief descriptions of applications for these accurate distance fields are given at the end of the paper.
The effect of thyrotropin releasing hormone on measures of mood in normal women.

Abstract 1 A double blind controlled trial of the psychotropic effects of thyrotropin releasing hormone (TRH) on normal women is described. 2 Single oral doses of this hormone, compared with identical placebo, had no effect on conventional measures of mood, but did cause definite effects as measured by clinical ethological observations of videotaped interviews.
Qualidade de vida de pessoas com doenças crônicas

Objetivo: identificar a qualidade de vida de pessoas com doencas cronicas, internadas em hospitais de Anapolis Goias. Metodo: trata-se de uma pesquisa quantitativa, transversal descritiva, utilizando o questionario WHOQOL – bref. Com amostra de 31 pacientes internados em dois hospitais da rede publica de saude de Anapolis/Goias com idade 57±1,34 anos, sendo a amostra representada por 15 homens e 16 mulheres, que apresentavam uma ou mais, dos principais tipos de doencas cronicas, sendo elas a hipertensao arterial, diabetes, câncer e doencas cardiovasculares. Foi feita uma analise descritiva dos dados. Resultados: com resultados no dominio fisico, a maioria dos individuos pesquisados foi classificada com 22,6% “muito ruim” 29% em “ruim”; no dominio psicologico com 32,3% como “nem boa e nem ruim”; no dominio social a maioria ja obteve um melhor resultado com 48,4% na classificacao “bom”; dominio ambiente com 45,2% “boa” e de acordo com a percepcao dos individuos a qualidade de vida foi classificada com 41,9% “nem boa, nem ruim”. Consideracoes finais: o estudo identificou que as pessoas com doencas cronicas avaliadas neste estudo, consideram sua qualidade de vida “nem ruim nem boa”, principalmente nos aspectos fisicos e psicologicos, a doenca cronica pode sim, ter afetado a qualidade de vida. Porem, traz resultados satisfatorios no dominio social, como apoio familiar e o dominio ambiente.
The Protein Tyrosine Kinase Tec Regulates a CD44highCD62L− Th17 Subset

The generation of Th17 cells has to be tightly controlled during an immune response. In this study, we report an increase in a CD44highCD62L− Th17 subset in mice deficient for the protein tyrosine kinase Tec. CD44highCD62L− Tec−/− CD4+ T cells produced enhanced IL-17 upon activation, showed increased expression levels of IL-23R and RORγt, and IL-23–mediated expansion of Tec−/− CD4+ T cells led to an increased production of IL-17. Tec−/− mice immunized with heat-killed Streptococcus pneumoniae displayed increased IL-17 expression levels in the lung postinfection with S. pneumoniae, and this correlated with enhanced pneumococcal clearance and reduced lung inflammation compared with Tec+/+ mice. Moreover, naive Tec−/− OT-II CD4+ T cells produced higher levels of IL-17 when cultured with OVA peptide-loaded bone marrow-derived dendritic cells that have been previously activated with heat-killed S. pneumoniae. Taken together, our data indicated a critical role for Tec in T cell-intrinsic signaling pathways that regulate the in vivo generation of CD44highCD62L− effector/memory Th17 populations.
Determining important factors on fish consumption with conjoint analysis in Tekirdag, Turkey

In the world, there is an increasing consumption trend from red meat to white meat, especially to the fish. Despite the known benefits of fish consumption on human health, it is still not at the desired level in Turkey. The average fish consumption is 5.58 kg per capita in Turkey, and it is below the World (14.9 kg) and the EU (16.89 kg) average fish consumption. The aim of the study was to determine the importance level given to the factors that respondents consider when purchasing fish. In this study, surveys were conducted with 248 respondents. Conjoint analysis was used to determine the most important factors that influence respondents while purchasing fish. According to the results, fish consumption per capita in Tekirdag is 14.69 kg per year. In conjoint analysis results for all respondents, the most important factors in fish consumption are price (34.2%), form (31.4%), production method (26.9%) and supply channel (7.5%). The factors that influence respondents are changing according to the income groups. While price is the most important factor for respondents with a monthly income 1210 EUR or less, respondents with monthly income 1210 EUR and above pay attention to the processing type factor. Fish price and form are the most important factors for respondents. Retailers should aim to deliver fresh fish to consumers with a low-price policy. Due to this, it is needed to establish fish markets where necessary food controls and inspections are made, consumers relied, complying with European Union standards, fresh and cheap fish is sold.
Resource Allocation in SWIPT Enabled Heterogeneous Cloud Small Cell Networks with Incomplete CSI

Heterogeneous cloud small cell network (HCSNet) with energy harvesting is a promising technique in the next generation mobile communications. However, the cross- tier and co-tier co-channel interference can be severe due to the spectrum sharing in inter-tier and intra- tier of HCSNet. This paper investigates the problem of power allocation and subchannel assignment with the consideration of cross-tier/co-tier interference mitigation, energy harvesting and incomplete channel state information. The power allocation problem in HCSNet is modeled as a non-cooperative game by introducing a time-varying cross-tier/co-tier interference pricing with simultaneous wireless information and power transfer. Subchannel allocation is modeled as a non-cooperative potential game by minimizing the the total interferences experienced by users on each subchannel. Iterative scheme of power optimization and subchannel allocation is proposed to obtain the Nash equilibrium points. Simulation results are presented to verify the effectiveness of the proposed algorithms in HCSNet.
The Stress and Strain of Triathlon Racing in Different Thermal Environments

Athletic endurance competitions in hot environments have become more relevant in professional sports. The inception for this thesis was to understand why a group of elite endurance triathletes repeatedly failed to perform in hot environments. The subsequent aims were to explore the physiological basis of elite endurance performance in the heat, with a focus on cerebrovascular responses because they seemed relevant and yet remained relatively less well explored. Four sequential studies addressed the thesis: 1) observe and measure athletes’ physiology and race behaviour, 2) measure physiological responses from shortduration, maximal-intensity exercise in controlled temperate (TEMP) vs hot