Miracle-dz/UniFAR-FTUs huggingface dataset:
Endovascular Therapy for Childhood Ischemic Stroke

Patient: Female, 7-year-old Final Diagnosis: Stroke Symptoms: Aphasia Medication:— Clinical Procedure: — Specialty: Neurology Objective: Rare disease Background: Ischemic stroke can have a tremendously negative impact on the fitness and well-being of a child. Because endovascular interventions may be of benefit in the adult stroke population, many investigators have recently evaluated the safety and benefits of pharmacological and non-pharmacological options in the pediatric stroke population and compared pediatric patients to their adult counterparts. Some of these trials have had promising results, showing the positive effects of endovascular treatment in children with arterial acute ischemic stroke due to large-vessel occlusion (LVO). The 2015 American Heart Association/American Stroke Association guidelines suggest that mechanical thrombectomy with stent retrievers may be a consideration in some patients who are younger than 18 years and have severe LVO, when treatment (groin puncture) is initiated within 6 h of symptom onset. However, the method remains under-studied in this age group. Case Report: A 7-year-old girl presented with migraine-like headache, right arm and facial weakness, and expressive aphasia 9.5 h after symptom onset. Her PEDS-NIH stroke scale score was 4. Upon further investigations, she was found to have a left middle cerebral artery cryptogenic stroke with a distal left M1 clot, which was successfully treated with mechanical thrombectomy. Huge improvement was noticed during her subsequent physical examination. Conclusions: Endovascular therapy offers an exciting treatment option for the management of pediatric stroke. The extent of safety of mechanical thrombectomy among children who present with large-vessel occlusion over an extended time window remains unknown and warrants further investigations.
Title Dynamic Scaling of Virtualized , Distributed Service Chains : ACase Study of IMS

The emerging paradigm of network function virtualization advocates deploying virtualized network functions (VNFs) on standard virtualization platforms for significant cost reduction and management flexibility. There have been system designs for managing dynamic deployment and scaling of VNF service chains within one cloud datacenter. Many real-world network services involve geo-distributed service chains, with prominent examples of mobile core networks and IP Multimedia Subsystems (IMSs)). Virtualizing these service chains requires efficient coordination of dynamic VNF deployment across geo-distributed datacenters, calling for a new management system. This paper designs a dynamic scaling system for geo-distributed VNF service chains, using the case of an IMS. IMSs are widely used subsystems for delivering multimedia services among mobile users in a 3G/4G network, whose virtualization has been broadly advocated in the industry for reducing cost, improving network usage efficiency and enabling dynamic network topology reconfiguration for performance optimization. Our scaling system design caters to key control-plane and data-plane service chains in an IMS, combining proactive and reactive approaches for timely, costeffective scaling of the service chains. The design principles are applicable to scaling of other systems with multiple related service chains. We evaluate our system using real-world experiments on both an emulation platform and a geo-distributed public cloud.
Bernoulli--Dedekind Sums

Let $p_1,p_2,\dots,p_n, a_1,a_2,\dots,a_n \in \N$, $x_1,x_2,\dots,x_n \in \R$, and denote the $k$th periodized Bernoulli polynomial by $\B_k(x)$. We study expressions of the form \[ \sum_{h \bmod{a_k}} \ \prod_{\substack{i=1\\ i\not=k}}^{n} \ \B_{p_i}\left(a_i \frac{h+x_k}{a_k}-x_i\right). \] These \highlight{Bernoulli--Dedekind sums} generalize and unify various arithmetic sums introduced by Dedekind, Apostol, Carlitz, Rademacher, Sczech, Hall--Wilson--Zagier, and others. Generalized Dedekind sums appear in various areas such as analytic and algebraic number theory, topology, algebraic and combinatorial geometry, and algorithmic complexity. We exhibit a reciprocity theorem for the Bernoulli--Dedekind sums, which gives a unifying picture through a simple combinatorial proof.
Primary l fA meta-ana ysis o surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease

Radiotherapy has been the primary therapy for managing metastatic spinal disease; however, surgery that decompresses the spinal cord circumferentially, followed by reconstruction and immediate stabilization, has also proven effective. We provide a quantitative comparison between the “new” surgery and radiotherapy, based on articles that report on ambulatory status before and after treatment, age, sex, primary neoplasm pathology, and spinal disease distribution. Ambulation was categorized as “success” or “rescue” (proportion of patients ambulatory after treatment and proportion regaining ambulatory function, respectively). Secondary outcomes were also analyzed. We calculated cumulative success and rescue rates for our ambulatory measurements and quantified heterogeneity using a mixed-effects model. We investigated the source of the heterogeneity in both a univariate and multivariate manner with a meta-regression model. Our analysis included data from 24 surgical articles (999 patients) and 4 radiation articles (543 patients), mostly uncontrolled cohort studies (Class III). Surgical patients were 1.3 times more likely to be ambulatory after treatment and twice as likely to regain ambulatory function. Overall ambulatory success rates for surgery and radiation were 85% and 64%, respectively. Primary l f A meta-ana ysis o surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease
The Potential Role of Saliva In Protecting Against Dental Caries

Previously, extensive research studies indicated that the dental caries is the result of microbial infection, as do influence by dietary and host factors. Recently, research studies seek to identify caries risk factors as well as identify natural oral defenses that may protect against and prevent caries progression. The early detected and diagnosed dental disease in pediatric age; the more suitable treatment will be administrated, thus reducing the intensity incidence of caries.Saliva and it is components play a vital role in protecting oral structures. Saliva consists of proteins which can be informative fordisease detection and observation of oral health. Saliva proteins affect the survival of oral microorganisms by multiple innate defensive mechanisms as well, thus modulating the oral microbial flora. Therefore, the proteins composition of saliva involves in the primary line of protection in the oral cavity. Current research has generated abundant information that contributes to a better understanding of theroles salivary proteins in caries occurrence and prevention. This review summarizes the tooth-protective salivary proteins.
On the functional relevance of spatiotemporally-specific patterns of experience-dependent long noncoding RNA expression in the brain

ABSTRACT The majority of transcriptionally active RNA derived from the mammalian genome does not code for protein. Long noncoding RNA (lncRNA) is the most abundant form of noncoding RNA found in the brain and is involved in many aspects of cellular metabolism. Beyond their fundamental role in the nucleus as decoys for RNA-binding proteins associated with alternative splicing or as guides for the epigenetic regulation of protein-coding gene expression, recent findings indicate that activity-induced lncRNAs also regulate neural plasticity. In this review, we discuss how lncRNAs may exert molecular control over brain function beyond their known roles in the nucleus. We propose that subcellular localization is a critical feature of experience-dependent lncRNA activity in the brain, and that lncRNA-mediated control over RNA metabolism at the synapse serves to regulate local mRNA stability and translation, thereby influencing neuronal function, learning and memory.
A Mutation in CsYL2.1 Encoding a Plastid Isoform of Triose Phosphate Isomerase Leads to Yellow Leaf 2.1 (yl2.1) in Cucumber (Cucumis Sativus L.)

The leaf is an important photosynthetic organ and plays an essential role in the growth and development of plants. Leaf color mutants are ideal materials for studying chlorophyll metabolism, chloroplast development, and photosynthesis. In this study, we identified an EMS-induced mutant, yl2.1, which exhibited yellow cotyledons and true leaves that did not turn green with leaf growth. The yl2.1 locus was controlled by a recessive nuclear gene. The CsYL2.1 was mapped to a 166.7-kb genomic region on chromosome 2, which contains 24 predicted genes. Only one non-synonymous single nucleotide polymorphism (SNP) was found between yl2.1 and wt-WD1 that was located in Exon 7 of Csa2G263900, resulting in an amino acid substitution. CsYL2.1 encodes a plastid isoform of triose phosphate isomerase (pdTPI), which catalyzes the reversible conversion of dihydroxyacetone phosphate (DHAP) to glyceraldehyde-3-phosphate (GAP) in chloroplasts. CsYL2.1 was highly expressed in the cotyledons and leaves. The mesophyll cells of the yl2.1 leaves contained reduced chlorophyll and abnormal chloroplasts. Correspondingly, the photosynthetic efficiency of the yl2.1 leaves was impaired. Identification of CsYL2.1 is helpful in elucidating the function of ptTPI in the chlorophyll metabolism and chloroplast development and understanding the molecular mechanism of this leaf color variant in cucumber.
Metacognitive Agent for Training Negotiation Skills

Training negotiators remains a difficult and expensive proposition. Negotiators require complex cognitive skills such as theory-of-mind to be successful, but these skills can be difficult to train and measure. Here we present an agent designed to model theory-of-mind for learners and serve as a practice partner for complex negotiations. This agent employs instancebased learning to make decisions about its own actions and to reflect on the behavior of the opponent. This reflection process is used to provide a source of explicit feedback on the opponent’s strategy and behavior. In this paper we present evidence that the model is a plausible opponent for students learning negotiation. It is expected that practicing with this agent will improve theory-of-mind abilities in learners and, in turn, improve negotiation performance.
Using X-ray Diffraction Techniques for Biomimetic Drug Development, Formulation, and Polymorphic Characterization

Drug development is a decades-long, multibillion dollar investment that often limits itself. To decrease the time to drug approval, efforts are focused on drug targets and drug formulation for optimal biocompatibility and efficacy. X-ray structural characterization approaches have catalyzed the drug discovery and design process. Single crystal X-ray diffraction (SCXRD) reveals important structural details and molecular interactions for the manifestation of a disease or for therapeutic effect. Powder X-ray diffraction (PXRD) has provided a method to determine the different phases, purity, and stability of biological drug compounds that possess crystallinity. Recently, synchrotron sources have enabled wider access to the study of noncrystalline or amorphous solids. One valuable technique employed to determine atomic arrangements and local atom ordering of amorphous materials is the pair distribution function (PDF). PDF has been used in the study of amorphous solid dispersions (ASDs). ASDs are made up of an active pharmaceutical ingredient (API) within a drug dispersed at the molecular level in an amorphous polymeric carrier. This information is vital for appropriate formulation of a drug for stability, administration, and efficacy purposes. Natural or biomimetic products are often used as the API or the formulation agent. This review profiles the deep insights that X-ray structural techniques and associated analytical methods can offer in the development of a drug.
Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus

While dengue virus (DENV) infection imposes a serious challenge to the survival of humans worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most devastating pandemic in human history. A significant number of studies have shown that plant-derived substances could serve as potential candidates for the development of safe and efficacious remedies for combating these diseases. Different scientific databases were used to source for literature on plants used against these infections. Thirty-five studies described the traditional use of 25 species from 20 families for treating DENV infection with Carica papaya and Euphorbia hirta were the most widely used across different regions. 13 in vivo studies, 32 in vitro studies, and eight clinical studies were conducted on 30 species from 25 families against different DENV serotypes, while plants from 13 families were reported to inhibit different forms of SARS-CoV, all of which were investigated through in vitro studies. Phytoconstituents belonging to various chemical classes were identified to show a wide range of antiviral activity against these infections. Extensive studies on the potentials of medicinal plants are needed to confirm their efficacy. This paper reveals the capabilities of medicinal plants and their phytochemicals in inhibiting DENV and SARS-CoV infections.
Somatic Embryogenesis in Centaurium erythraea Rafn—Current Status and Perspectives: A Review

Centaurium erythraea (centaury) is a traditionally used medicinal plant, with a spectrum of secondary metabolites with confirmed healing properties. Centaury is an emerging model in plant developmental biology due to its vigorous regenerative potential and great developmental plasticity when cultured in vitro. Hereby, we review nearly two decades of research on somatic embryogenesis (SE) in centaury. During SE, somatic cells are induced by suitable culture conditions to express their totipotency, acquire embryogenic characteristics, and eventually give rise to somatic embryos. When SE is initiated from centaury root explants, the process occurs spontaneously (on hormone-free medium), directly (without the callusing phase), and the somatic embryos are of unicellular origin. SE from leaf explants has to be induced by plant growth regulators and is indirect (preceded by callusing). Histological observations and culture conditions are compared in these two systems. The changes in antioxidative enzymes were followed during SE from the leaf explants. Special focus is given to the role of arabinogalactan proteins during SE, which were analyzed using a variety of approaches. The newest and preliminary results, including centaury transcriptome, novel potential SE markers, and novel types of arabinogalactan proteins, are discussed as perspectives of centaury research.
Cartan Actions of Higher Rank Abelian Groups and their Classification

We study $\mathbb{R}^k$ actions with a dense set of Anosov elements and 1-dimensional coarse Lyapunov foliations. Such actions are called totally Cartan actions. When $k \ge 2$, we classify totally Cartan actions up to smooth conjugacy under mild transitivity assumptions. These are the first classification results for $k = 2$. When $k \ge 3$, we improve known partial results by removing the requirement of an invariant measure and related ergodicity assumptions. We are also for the first time able to work in low regularity.
Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective

Vitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air, perfluorocarbons, silicone oil and expansile gases serve only as a short-term solution and harbors various disadvantages. However, an ideal long-term substitute is yet to be discovered and recent research emphasizes on the potential of polymeric hydrogels as an ideal vitreous substitute. This review highlights the recent progress in the field of vitreous substitution. Suitability and adverse effects of various tamponade agents in present day clinical use and biomaterials in the experimental phase have been outlined and discussed. In addition, we introduced the anatomy and functions of the native vitreous body and the pathological conditions which require vitreous replacement.
Flavones, Flavonols, and Glycosylated Derivatives—Impact on Candida albicans Growth and Virulence, Expression of CDR1 and ERG11, Cytotoxicity

Due to the high incidence of fungal infections worldwide, there is an increasing demand for the development of novel therapeutic approaches. A wide range of natural products has been extensively studied, with considerable focus on flavonoids. The antifungal capacity of selected flavones (luteolin, apigenin), flavonols (quercetin), and their glycosylated derivatives (quercitrin, isoquercitrin, rutin, and apigetrin) along with their impact on genes encoding efflux pumps (CDR1) and ergosterol biosynthesis enzyme (ERG11) has been the subject of this study. Cytotoxicity of flavonoids towards primary liver cells has also been addressed. Luteolin, quercitrin, isoquercitrin, and rutin inhibited growth of Candida albicans with the minimal inhibitory concentration of 37.5 µg/mL. The application of isoquercitrin has reduced C. albicans biofilm establishing capacities for 76%, and hyphal formation by yeast. In vitro treatment with apigenin, apigetrin, and quercitrin has downregulated CDR1. Contrary to rutin and apigenin, isoquercitrin has upregulated ERG11. Except apigetrin and quercitrin (90 µg/mL and 73 µg/mL, respectively inhibited 50% of the net cell growth), the examined flavonoids did not exhibit cytotoxicity. The reduction of both fungal virulence and expression of antifungal resistance-linked genes was the most pronounced for apigenin and apigetrin; these results indicate flavonoids’ indispensable capacity for further development as part of an anticandidal therapy or prevention strategy.
Microstructural Origin of the Double Yield Points of the Metallocene Linear Low-Density Polyethylene (mLLDPE) Precursor Film under Uniaxial Tensile Deformation

The microstructural origin of the double yield points of metallocene linear low-density polyethylene (mLLDPE) precursor films has been studied with the assistance of the synchrotron radiation small- and wide-angle X-ray scattering (SAXS/WAXS). It has been shown that the microstructural origin of the double yield points is highly related to the initial orientation of the original precursor film. For less oriented mLLDPE precursor films, the rearrangement of lamellae and the appearance of the monoclinic phase are the microstructural origins of the first yield point. In comparison, for the highly-oriented mLLDPE precursor film, only the orthorhombic-monoclinic phase transition appears at the first yield point. The melting-recrystallization and the formation of the fibrillary structure happen beyond the second yield point for all studied mLLDPE precursor films. Finally, the detailed microstructural evolution roadmaps of mLLDPE precursor films under uniaxial tensile deformation have been established, which might serve as a guide for processing high-performance polymer films by post-stretching.
Indoor Radon Measurements in Plovdiv City

Radon is a radioactive gas that is formed naturally by the breakdown of uranium in soil, rock and water. Recent epidemiological findings from residential studies demonstrate a statistically significant increase of lung cancer risk from prolonged exposure to indoor radon. The new requirements of ICRP and WHO include the control of indoor exposure due radon and establishment of a reference level for the annual average activity concentration up to 300 Bq/m for existing dwellings and public buildings. In this paper the results of indoor radon survey in Plovdiv city are presented. Radonmeasurementsweremade in 44 dwellings and 91 kindergartens by using CR-39 nuclear track detectors. The detectors in dwellings were exposed for 6 months from October 2011 to May 2012 while the detectors in kindergartens for 3 month from January to April 2014. The average annual indoor radon concentration (GM) for dwelling was found to be 100 Bq/m and for kindergartens 230 Bq/m. The maximummeasurement value of radon concentration in dwellings was 930 Bq/m and for kindergartens 1094 Bq/m. The radon concentrations in dwellings were compared with that in kindergartens and the results show that kindergartens have a high indoor radon concentration than dwellings. A detailed statistical analysis of the building factors was presented as well as the risk from radon exposure was assessed.
Mimicking the Mammalian Plasma Membrane: An Overview of Lipid Membrane Models for Biophysical Studies

Cell membranes are very complex biological systems including a large variety of lipids and proteins. Therefore, they are difficult to extract and directly investigate with biophysical methods. For many decades, the characterization of simpler biomimetic lipid membranes, which contain only a few lipid species, provided important physico-chemical information on the most abundant lipid species in cell membranes. These studies described physical and chemical properties that are most likely similar to those of real cell membranes. Indeed, biomimetic lipid membranes can be easily prepared in the lab and are compatible with multiple biophysical techniques. Lipid phase transitions, the bilayer structure, the impact of cholesterol on the structure and dynamics of lipid bilayers, and the selective recognition of target lipids by proteins, peptides, and drugs are all examples of the detailed information about cell membranes obtained by the investigation of biomimetic lipid membranes. This review focuses specifically on the advances that were achieved during the last decade in the field of biomimetic lipid membranes mimicking the mammalian plasma membrane. In particular, we provide a description of the most common types of lipid membrane models used for biophysical characterization, i.e., lipid membranes in solution and on surfaces, as well as recent examples of their applications for the investigation of protein-lipid and drug-lipid interactions. Altogether, promising directions for future developments of biomimetic lipid membranes are the further implementation of natural lipid mixtures for the development of more biologically relevant lipid membranes, as well as the development of sample preparation protocols that enable the incorporation of membrane proteins in the biomimetic lipid membranes.