Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic alteration and prospective signaling pathways of miR-517 a-3 p in bladder cancer : a study based on miRNA sequencing data and bioinformatics methods

Purpose: To explore the clinicopathological value and prospective function of microRNA-517a-3p (miR517a-3p) in bladder cancer (BC). Methods: The clinical importance of miR-517a-3p expression and genetic alteration in BC was unraveled by using The Cancer Genome Atlas (TCGA), cBioPortal, Gene Expression Omnibus (GEO) and ArrayExpress. The potential target genes of miR-517a-3p were obtained via the combination of predicted genes and down-regulated genes post miR-517a-3p transfection in vitro from microarray (GSE39093). The probable signaling pathways were further evaluated with multiple bioinformatics approaches. Results: MiR-517a-3p expression was significantly higher in the samples of pathologic N stage (N1-N3), pathologic stage (III-IV) and patients with lymphovascular invasion than that of their counterparts (P<0.05) based on data from TCGA. The amplification was the only alteration type which counted for 3% (14/412) in BC as indicated by cBioPortal. A total of 858 genes were gained by prediction from at least two predicting programs. Compared to control cells, there were 4844 genes downexpressed after BC cells (BOY and T24) were transfected with miR-517a-3p. Only “hsa05200: Pathways in cancer” was significantly enriched via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis (P<0.05). Three significant pathways were discovered in PANTHER pathway analysis (P<0.05). Hub genes, such as CREB1, MAPK1, RPS6KA5, SMAD3 and PPARA, were identified by protein-protein interaction. Conclusion: The results in this study indicate that miR-517a-3p may play a potential role in the occurrence and development of BC, especially its genetic alteration, via various signal pathways. However, the exact mechanism still needs to be ascertained by in vitro and in vivo experiments.
CARCASS TRAITS OF CROSSBRED RABBIT BUCKS FED DIETS SUPPLEMENTED WITH PUMPKIN STEM WASTE

A study was conducted to evaluate the effect of supplementing diets with varying levels of pumpkin stem waste (PSW) on carcass traits as well as performance of rabbits. Twenty four crossbred (Dutch x Chinchilla) rabbit bucks aged 6 to 7 weeks were divided into four treatment groups of six (6) bucks each with two bucks per replicate. The bucks were randomly allotted to four dietary treatments arranged as follows; T1 (basal diet only); T2 (basal diet + 5% PSW); T3 (basal diet + 10% PSW); T4 (basal diet + 15% PSW). Each diet was fed to a group of the six rabbit bucks. At the end of 56 days, 8 bucks were slaughtered (2 per treatment). Results obtained indicate that bucks fed diets T2, T3 and T4 increased in feed intake significantly (p < 0.05) compared to those fed the control diet while daily weight gain, feed conversion ratio and cost per weight gain indicated no significant differences (P > 0.05) . However, carcass traits particularly abdominal fat and liver weights indicate significant reduction (P < 0.05) as dietary pumpkin stem increased. These results suggest that supplementing rabbit diets with pumpkin stem waste could increase feed intake as well as improve meat quality due to fat reduction.
Organochlorine insecticide residues in raw milk sold in Córdoba , Colombia

In this investigation organochlorine pesticide residues in raw milk from Dairy herds in Cordoba were determined. During the extraction procedure it was used acolumn of diatomaceous earth as eluting system and a mixture of n-hexane-acetone-ethyl acetate (4:2:1), followed by 5% methanol in hexane. For the determination we used a gas Chromatograph Perkin Elmer, Autosystem XL with electron capture detector, splitless injection mode, a capillary column Rtx-5 30m, 0.25 mm id and 0.25 μm film thickness. The recovery rates for certain pesticides were between 88.5 and 96%, the detection limits were defined between 0.01 and 0.04 ng/g, with relative standard deviations less than 6%. In the 63 samples tested p, p'-DDT, αHCH, δ-HCH, aldrin, dieldrin, endrin, heptachlor, heptachlor epoxide and γ-chlordane were determined, establishing concentrations between 27.1 and 469.6 ng/g. The frequencies of occurrence ranged between 1.6 and 65.1% for heptachlor and p, p'-DDT, respectively. The older population that lives in the subregions: Middle Sinú, San Jorge and Savannas were exposed to high health risk associated with the concentration of α-HCH, aldrin and dieldrin in raw milk.
Application of methods of strategic management in developing urban renewal programs in the largest cities in Poland

Development and implementation of strategies in public sector organisations or in networks of private and public entities is strongly prone to influences of political nature. One of the key functions of the development program in the city is either elimination or limitation of negative impacts of potential conflicts which may emerge among the participants of local development system of the city. Strategy or any other shorter-term development program requires wide consensus, gaining which should enable all the actors to achieve their individual and common objectives. Methods of development of a strategy must create conditions and climate for cooperation and reduce tension. K. Wrana proposes performing subjective analysis by which there will be created a list of entities creating local development system [1]. These organisations need to be equipped with particular tools which will firstly facilitate the process of selection, evaluation and identification of relations between the participants of strategic process, secondly – facilitate the analysis of local macroand microenvironment, thirdly – determine threats, opportunities, advocates and adversaries, as well as strengths and weaknesses of the concept of development. Finally – local development system must be also equipped with tools that facilitate identification of problems and needs, creation of solutions of the identified problems and issues, as well as mechanisms of evaluation and ranking them. For the first step, the Wrana recommends the following:  Identification of organisations having impact of strategic directions of development of the city, particularly the ones that control resources,  Description and explanation of behaviour of particular entities, identification of their individual objectives,  Modelling of mutual relations between the identified organisations in order to identify the areas of potential cooperation.
on the Lactic Acid Bacteria Probiotic in the Control of

Control and prevention of diseases such as coccidiosis, salmonellosis, and campylobacteriosis in the poultry industry are particularly important. Coccidiosis is the most common diseases in broilers, and salmonellosis and campylobacteriosis are two food-borne important diseases in human caused from food animals. Iran's climate is appropriate for the spread of the coccidiosis and has caused great economic losses in the poultry industry (Baba Ahmadi et al. 2009). This disease is caused by a parasite known as Eimeria. The parasite multiplies in the digestive system, and leads to the mortality, malabsorption and reduced growth in the broilers and decreased egg production in laying hens (Lillehoj et al. 2004). Drugs and live vaccine are two main methods to control this disease. However, due to problems caused by longterm consumption of medicines and high cost of vaccines, the use of more effective and safer methods are needed (Dalloul and Lillehoj, 2006; Williams, 2006). On the other hand, Salmonella and Campylobacter are the agents of the most important food-borne infectious diseases in humans and the poultry products are the most important sources of human infection with these bacteria. Gram-negative bacterium Campylobacter jejuni is the pathogen of this intestinal food borne disease. Since the ban on the use of antibiotic growth stimulants in Europe, problems caused by Salmonella have increased. It was reported that 24% of the examined broiler flocks were positive for Salmonella colonization (European Food Safety Authority, 2007). Roles of probiotic microorganisms in digestive physiology are contributed to enhancing animals health and reducing the incidence of gastrointestinal diseases. Banning the use of antibiotics as growth promoters in poultry in many countries has been contributed to the increasing use of probiotics because long-term use of antibiotics causes antibiotic resistance of pathogenic bacteria in poultry and subsequently in the man, the vaccines are also costly. Salmonellosis, campylobacteriosis and coccidiosis infections are the most common intestinal diseases in the poultry industry. The pathogens causing these diseases are Salmonella enteritidis, Campylobacter jejuni, and Eimeria tenella, respectively. Probiotics are able to control these diseases. Certainly, controlling the causes of these disease outbreaks will promote the public health. On the other hand, the probiotics increase bird resistance against the invasion of Eimeria that may lead to protect against coccidiosis. This review deals to the potential of lactic acid probiotic bacteria to control coccidiosis, campylobacteriosis and salmonellosis.
Impact of Biofield Energy Healing Treatment: Evaluation of AntiRheumatoid Activity Using Synovial Sarcoma Cell Line (SW982)

The present research was performed to monitor the anti-rheumatoid action of Consciousness Energy Healing based DMEM medium using synovial sarcoma cell line, SW982. The study included the evaluation of bone health potential using inflammatory parameter, IL-8. The test item (DMEM medium) was divided into three parts, first part received a one-time Consciousness Energy Healing Treatment by a renowned Biofield Energy Healer, Mahendra Kumar Trivedi and was labeled as the one-time Biofield Energy Treated (BT-I) DMEM, while second part received the two-times the Biofield Energy Treatment and is denoted as BT-II DMEM. The third part did not receive any treatment and defined as the untreated DMEM group. Cell viability assay using MTT method showed that the cell viability of SW982 cells was 113.8% and 88.3% in the BT-I and BT-II groups, respectively. The BT-I group demonstrated significant (p≤0.001) inhibition of IL-8 by 27.74%, while BT-II group also showed a significant (p≤0.001) inhibition of IL-8 by 45.66% as compared to the untreated DMEM group. In conclusion, the data suggested that the Consciousness Energy Healing Treatment significantly inhibited the pro-inflammatory cytokine (IL-8) that showed anti-rheumatic action and can also be used in other bone and inflammatory disorders such as osteoporosis, Paget’s disease of bone, rickets, deformed bones, osteomalacia, osteoma, stress, aging, bone loss, and fractures along with autoimmune disorders and overall quality of life.
Intelligent Vehicle Global Path Planning Based on Improved Particle Swarm Optimization

Intelligent Transportation System (ITS) is able to reduce traffic jams and the incidence of accidents, and it is the current research hotspot. Intelligent vehicle is the key element of ITS, and path planning is one of the key technologies of intelligent vehicle. Particle Swarm Optimization (PSO) is a swarm-based intelligence algorithm. Using PSO for path planning can achieve good results. In order to improve PSO to get a better path planning result, a nonlinear inertia weight is proposed. The improved PSO and traditional PSO are compared in a global complex environment and the simulation results show that the improved PSO has a shorter path and better real-time performance.
PARALLEL MICROCONTROLERS AT 89 C 52 : PARALLEL PROCESSORS IN EMBEDDED SYSTEM APPLICATION OF ROBOTICS

ABSTRAK Paralelisme merupakan isu yang sedang berkembang dalam dunia teknologi informasi. Sistem ini menjadi alternatif bagi penyeimbangan antara kinerja dan biaya. Akan tetapi, migrasi suatu sistem menjadi sistem paralel dapat memunculkan isu-isu baru dalam hal komunikasi dan koordinasi di antara prosesor-prosesor. Di samping itu, suatu sistem paralel umumnya memiliki struktur dan cara kerja yang rumit karena ditujukan untuk menyelesaikan berbagai permasalahan yang rumit pula. Makalah ini mencoba untuk menyajikan pembangunan sistem paralel dengan menggunakan mikrokontroler yang merupakan prosesor murah, berkemampuan rendah, dan terbatas pada penggunaan spesifik, tetapi telah memiliki fasilitas-fasilitas minimum sebagai suatu sistem komputer. Untuk itu, rangkaian mikrokontroler juga dapat dibentuk menjadi suatu sistem paralel dengan kemampuan cukup baik untuk aplikasi-aplikasi tertentu. Salah satu implementasi kontroler yang terus berkembang dengan pesat adalah dalam dunia robotika. Robot-robot yang semakin kompleks akan memerlukan prosesor-prosesor terpisah untuk menangani beberapa fungsinya yang modular. Dengan demikian, konsep-konsep paralelisme yang dihasilkan dari sistem paralel mikrokontroler ini dapat diadaptasi untuk diterapkan dalam robotika. Analisis mengenai hal ini juga akan disajikan pada bagian akhir makalah. Kata Kunci: Parallel, Microcontroller, Embedded System, Robotics
Hypertension Intensive Cholesterol Reduction Lowers Blood Pressure and Large Artery Stiffness in Isolated Systolic Hypertension

OBJECTIVES We sought to investigate the effects of intensive cholesterol reduction on large artery stiffness and blood pressure in normolipidemic patients with isolated systolic hypertension (ISH). BACKGROUND Isolated systolic hypertension is associated with elevated cardiovascular morbidity and mortality and is primarily due to large artery stiffening, which has been independently related to cardiovascular mortality. Cholesterol-lowering therapy has been efficacious in reducing arterial stiffness in patients with hypercholesterolemia, and thus may be beneficial in ISH. METHODS In a randomized, double-blinded, cross-over study design, 22 patients with stage I ISH received three months of atorvastatin therapy (80 mg/day) and three months of placebo treatment. Systemic arterial compliance was measured noninvasively using carotid applanation tonometry and Doppler velocimetry of the ascending aorta. RESULTS Atorvastatin treatment reduced total and low-density lipoprotein cholesterol and triglyceride levels by 36 2% (p 0.001), 48 3% (p 0.001) and 23 5% (p 0.003), respectively, and increased high density lipoprotein cholesterol by 7 3% (p 0.03). Systemic arterial compliance was higher after treatment (placebo vs. atorvastatin: 0.36 0.03 vs. 0.43 0.05 ml/mm Hg, p 0.03). Brachial systolic blood pressure was lower after atorvastatin treatment (154 3 vs. 148 2 mm Hg, p 0.03), as were mean (111 2 vs. 107 2 mm Hg, p 0.04) and diastolic blood pressures (83 1 vs. 81 2 mm Hg, p 0.04). There was a trend toward a reduction in pulse pressure (71 3 vs. 67 2 mm Hg, p 0.08). CONCLUSIONS Intensive cholesterol reduction may be beneficial in the treatment of patients with ISH and normal lipid levels, through a reduction in large artery stiffness. (J Am Coll Cardiol 2002; 39:1020–5) © 2002 by the American College of Cardiology Foundation
Geophagy by the Bonnet Macaques ( Macaca radiata ) of Southern India : A Preliminary Analysis

Bonnet macaques (Macaca radiata) in the Marakkanam Reserved Forest of southern India consume termitaria soils. Samples from the ingested termite mounds are compared with samples taken from the surrounding uneaten soils in an attempt to determine why the termitaria soils are eaten. Particle size, clay and primary mineral composition, geochemistry and scanning electron microscopic analyses are used to search for a possible explanation for geophagy among the bonnet macaques. Kaolin minerals abound throughout the Marakkanam soil sample suite. But the termitaria soils are distinguished by the presence of small amounts of smectite. An abundance of kaolin minerals in combination with small amounts of smectite strongly resembles the mineralogy of eko, a traditional African remedy for stomach ailments, and Kaopectate, a western anti-diarrhoeal preparation. The percentage of mature leaves and fruits of Azadirachta indica consumed by the bonnet macaques is relatively high. Plant feeding deterrents, such as, acid detergent fibre (ADF) and the inherent nature of the fruits of Azadirachta indica, when consumed in large quantities to act as a purgative, could cause gastrointestinal upsets and diarrhoea. At Marakkanam, bonnet macaques ingest termitaria earth that would act as a pharmaceutical agent to alleviate gastrointestinal upsets and control diarrhoea.
Using Micro-robots as a Tool for Insect Behavior Studies

This paper presents a multidisciplinary experiment setup inspired on the LEURRE project where robots are used for animal behavior studies in a robot/animal mixedsociety. Crickets of the species Gryllus bimaculatus are let interact with micro-robots equipped with decoys or lures. Unlike previous work, here we use the robots as tools focusing on the insect study itself rather than attempting to design an autonomous robot that mimics cricket behavior. A set of experiments is performed demonstrating the new ways in which even simple open-loop robot movement playback can be successfully used for animal behavior exploration. These experiments focused on the comparative study of the escaping behavior of dominant and subordinate male crickets after a dominance dispute is settled. Results are shown and discussed.
ISO DR-Core (ISO 24617-8): Core Concepts for the Annotation of Discourse Relations

This paper summarizes ISO 24617-8 (ISO DR-Core), a new part of the ISO SemAF framework for semantic annotation. Within this framework a range of standards is developed to support the interoperable annotation of semantic phenomena. The effort to develop a standard for the annotation of semantic relations in discourse is split into two parts, of which ISO 24617-8 concerns the first part, formulating desiderata for the annotation of discourse relations and providing clear definitions for a set of ‘core’ discourse relations, based on an analysis of a range of theoretical approaches and annotation efforts. Following the ISO principles for semantic annotation, an abstract syntax as well as a concrete XML-based syntax for annotations were defined, together with a formal semantics. Mappings are provided between the ISO core relations and various other annotation schemes.
Foreign Direct Investment , Foreign Aid and Incomes Inequality in Selected African and South American Countries

There is growing evidence that income inequality has been increasing over the years, and that it has consequences for social stability and peace because extreme inequality often leads to civil unrest and violence. Given an increasing level of resource transfers to developing countries in the forms of foreign direct investment (FDI) and foreign aid (FA) as well as growth in international trade over the years, an interesting research question arises—how have these resources affected income distribution in developing countries? While both of these foreign capital resources have been found to significantly influence the scope and rate of economic growth in developing countries, very few studies have directly tested the effect of FDI and FA on income inequality in developing countries, especially for African and South American countries where the problems of economic growth and income distribution need to be addressed. Also, there is literature suggesting both positive and negative effects of globalization or openness of economies, thus making it an issue requiring empirical verification. In an effort to fill in the gap in the literature, this paper reports results of an empirical study examining the impact of openness, FDI and FA on income inequality in 71 selected African and South American countries for the period 1970-2014.
Magnetic lump model for the hysteresis frequency dependence of a polymer matrix

Based on complex space discretized hysteresis model of the ferromagnetic materials (including both macroscopic and microscopic eddy currents contributions), a simplified magnetic lump model of a polymer matrix material filled with magnetic particles is proposed in this paper. Due to its intrinsic nature, even for high percentage of magnetic particles, the tested sample exhibit high resistivity. This property implies a high limitation of the macroscopic eddy currents development. Considering this characteristic, the model proposed is limited to the microscopic eddy currents (related to the domain wall motions) contribution, and then checked and validated by comparing simulated/measured results on a large frequency bandwidth. A quite simple consideration of the frequency magnetic hysteresis dependence in such flexible magnetic materials is established and consolidated by testing it on a new material the validity of the microscopic eddy currents model.
THE INFLUENCE OF THE PREPARATION OF THE RADICULAR DENTINE SURFACE ON ITS ADHESION TO HERCULITE MATERIAL

The aim of this study is to compare the influence of EDTA and citric acid on adhesion between radicular dentine and composite material Herculite. Appropriate adhesion between filling material and tooth structure constitutes proper protection against coronal leakage, indispensable to achieve a satisfactory effects in dentistry treatment. Forty human teeth molars roots, removed from dentistry indications were used in this study. Twenty randomly selected teeth were sliced perpendicularly to the long axis of dental radices (I group), following 20 parallely (group II). In the group I dentinal tubules were parallel to the analysed surface, whereas in group II perpendicular. Transversal and longitudinal teeth profiles were randomly divided into two subgroups of ten teeth each and activated by solutions which are commonly used in endodontic treatment and 37% ortophosphoric acid. Slices of all teeth were covered with a bonding system OptiBond Solo Plus and light cured. On the surfaces prepared in this way, Herculite composite material with using special form of 3 mm in diameter, was applied. The findings reveal that there are not statistical differences in shear strength between the dentine and Herculite material. Also the direction of the dentinal tubules does not influence the shear strength of the analysed
Product Life Cycle, Learning, and Nominal Shocks

This paper documents a new set of stylized facts on how pricing moments depend on product age and emphasizes how this heterogeneity is crucial for the amplification of nominal shocks to the real economy. Exploiting information from a unique panel containing billions of transactions in the U.S. consumer goods sector, we show that our empirical findings are consistent with a narrative in which firms face demand uncertainty and learn through prices. Such a mechanism of active learning from prices can strongly influence an economy’s aggregate price level and can thus be important for assessing the degree of monetary non-neutrality. To quantify this, we build a general equilibrium menu cost model with active learning and exogenous entry that features heterogeneity in pricing moments over the life cycle of products. Under this setup, firms engage in active learning to deal with uncertainty on their demand curves. Firms choose prices not only to maximize static profits, but also to create signals to obtain valuable information on their demand. In the calibrated version of our model, the cumulative real effects of a nominal shock are approximately three times as large compared to a standard price-setting model. The main intuition behind this result is that active learning weakens the selection effect. Price changes are mainly determined by forces of active learning and, hence, become more orthogonal to aggregate shocks, which reduces the aggregate price flexibility of the economy.