Miracle-dz/UniFAR-FTUs huggingface dataset:
Facebook usage in promoting the academia expertise

This paper means to contemplate online social media usage on knowledge sharing among academia. In the past, numerous researches have been done to investigate how people in general make utilization of this innovation. However there are still restricted studies on how this technological advancement affects the scholarly world. Moreover, in Malaysia most research done in studying the effect of social media is focused on students rather than from academia perspective. For this study, Facebook is chosen as one of online social networking tool for knowledge sharing. Firstly, this study is begun with the exploration of factors that motivate the academia to share their insight through online networking. From the literature review analysis, ability to communicate with colleagues is the most cited reason showing the adoption of social media tools by academia. To understand more on how the Malaysian academia utilizes Facebook as a medium of knowledge sharing, a content analysis on a Facebook page is done. Content analysis is used to study the frequency of post as well as topics discussed among the academia. The findings reveal that there are four main topics regularly shared by the academia which are are information and current news, motivational quote, personal advice from life experience and program promoted.
Molecular Docking Studies of Novel Palmitoyl‐ligands for Cyclooxygenase‐2

An in silico approach was adopted to identify potential cyclooxygenase‐2 inhibitors through molecular docking studies. The in vivo studies indicated that synthetic palmitoyl derivatives of salicylic acid, para amino phenol, para amino benzoic acid, and anthranilic acid possessed significant pharmacological activities like anti‐inflammatory, analgesic, and antipyretic activities. None of the tested substances produced any significant gastric lesions in experimental animals. In an attempt to understand the ligand–protein interactions in terms of the binding affinity, the above synthetic molecules were subjected to docking analysis using AutoDock. The palmitoyl derivatives palmitoyl anthranilic acid, palmitoyl para amino benzoic acid, palmitoyl para amino phenol, and palmitoyl salicylic acid showed better binding energy than the known inhibitor diclofenac bound to 1PXX. All the palmitoyl derivatives made similar interactions with the binding site residues of cyclooxygenase‐2 as compared to that of the known inhibitor. Thus, structure‐based drug discovery approach was successfully employed to identify some promising pro‐drugs for the treatment of pain and inflammation.
Possible means of introduction of bluetongue virus serotype 8 (BTV-8) to Sweden in August 2008: comparison of results from two models for atmospheric transport of the Culicoides vector

In September 2008, bluetongue virus serotype 8 (BTV-8) infection was detected for the first time in Sweden, in a dairy herd on the west coast. Two different previously published operational atmospheric dispersion models indicate that midges from infected regions in Europe are likely to have reached Sweden by atmospheric transport during an estimated infection window. Both models indicated that the likely dates for the incursion of midges were overnight on August 6 to 7 and August 14 to 15; however, the less constrained model indicated a number of additional possible dates. The distribution of infected herds detected by active surveillance coincides with the regions that were indicated by the models to have been reached by midges from regions in Denmark and Germany with infected herds. It is likely that several points of introduction of infected midges occurred, possibly on different occasions. No alternative routes for introduction of the infection to Sweden were identified, supporting the theory that BTV-8 was introduced by infected midges carried by the wind.
ENT1 regulates ethanol-sensitive EAAT2 expression and function in astrocytes.

BACKGROUND Equilibrative nucleoside transporter 1 (ENT1) and excitatory amino acid transporter 2 (EAAT2) are predominantly expressed in astrocytes where they are thought to regulate synaptic adenosine and glutamate levels. Because mice lacking ENT1 display increased glutamate levels in the ventral striatum, we investigated whether ENT1 regulates the expression and function of EAAT2 in astrocytes, which could contribute to altered glutamate levels in the striatum. METHODS We examined the effect of ENT1 inhibition and overexpression on the expression of EAAT2 using quantitative real-time PCR and measured glutamate uptake activity in cultured astrocytes. We also examined the effect of 0 to 200 mM ethanol doses for 0 to 24 hours of ethanol exposure on EAAT2 expression and glutamate uptake activity. We further examined the effect of ENT1 knockdown by a specific siRNA on ethanol-induced EAAT2 expression. RESULTS An ENT1-specific antagonist and siRNA treatments significantly reduced both EAAT2 expression and glutamate uptake activity while ENT1 overexpression up-regulated EAAT2 mRNA expression. Interestingly, 100 or 200 mM ethanol exposure increased EAAT2 mRNA expression as well as glutamate uptake activity. Moreover, we found that ENT1 knockdown inhibited the ethanol-induced EAAT2 up-regulation. CONCLUSIONS Our results suggest that ENT1 regulates glutamate uptake activity by altering EAAT2 expression and function, which might be implicated in ethanol intoxication and preference.
Interior-Point Methods: Worst Case and Average Case Analysis of a Phase-I Algorithm and a Termination Procedure

We are interested in the average behavior of interior-point methods (IPMs) for linear programming problems (LPs). We use the rotation-symmetry-model as the probabilistic model for the average case analysis. This model had been used by Borgwardt in his average case analysis of the simplex-method. IPMs solve LPs in three phases. First, one has to find an appropriate starting point, then a sequence of interior points is generated, which converges to the optimal face. Finally, the optimum has to be calculated, as it is not an interior point. We present upper bounds on the average number of iterations in the first and the third phase by looking at random figures of the underlying polyhedron. These bounds show, that IPMs solve LPs in strongly polynomial time in the average case, so only the dimension parameters and not the encoding length of the problem determine the average behavior of IPMs.
Extending Regional Seismic Travel Time (RSTT) Tomography to New Regions

Lowering the global seismic detection threshold can be accomplished by introducing data recorded at regional distances (<2000 km from the event) into global monitoring systems. Unfortunately, introduction of regional data degrades average epicenter accuracy compared to locations constrained solely by data recorded at greater distances. Location accuracy degrades because regional seismic travel time (RSTT) prediction error is generally greater than prediction error for waves that travel to greater distances. In previous work we developed a computationally efficient method to capture the first-order effects of three-dimensional (3-D) crust and upper mantle structure on RSTTs. Previous results demonstrate that RSTT prediction accuracy is greatly improved by seismic tomography, in which model velocities are adjusted so that predicted travel times are in agreement with travel times that are based on a dataset of accurate event locations and arrival-time measurements. We have conducted RSTT tomography for the regional phases Pn, Pg, Sn, and Lg across Eurasia and for the Pn phase across North America. After tomography across Eurasia and North America, rigorous tests find that the standard deviation of Pn travel time residuals is reduced from approximately 1.75 seconds (ak135 model) to approximately 1.25 seconds. Further, the median location error is reduced from approximately 15 km to 9 km for network configurations that effectively average out measurement error. Reduction of epicenter error, millisecond travel time computation, and the flexibility to compute travel times between arbitrary points on/in the globe all make the RSTT method ideal for routine location work and for use in seismic monitoring systems. Extension of RSTT tomography to additional regions is a necessary step towards making the RSTT approach truly global and therefore attractive to monitoring agencies, such as the International Data Center at the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO), the National Earthquake Information Center (NEIC), and the International Seismic Centre (ISC). Geographic extension of RSTT tomography through regional cooperation is currently being pursued. In the regional cooperation approach, scientists from study regions participate in the development of high-quality data sets, tomography, and model validation. A regional cooperation approach works towards producing the most complete tomographic data set, and it provides a better understanding of the RSTT approach to the international scientific community.
Database Marketing Analyzing And Managing Customers

Thank you very much for downloading database marketing analyzing and managing customers. Maybe you have knowledge that, people have look numerous times for their chosen readings like this database marketing analyzing and managing customers, but end up in infectious downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they juggled with some malicious bugs inside their computer.
Robust Tube-Based Predictive Control for Visual Servoing of Constrained Differential-Drive Mobile Robots

This paper proposes a control strategy for the vision-based control problem of a nonholonomic constrained differential-drive mobile robots with bounded disturbance by using robust tube-based model predictive control (MPC) method. The proposed control strategy mainly consists of an ancillary state feedback controller and an MPC control for a nominal robotic system. First, the state-error kinematics of the nominal system is converted into a chained form system, and then its MPC optimization is computed to deal with a quadratic programming optimization problem by integrating a linear variable inequality-based primal-dual neural network (LVI-PDNN). Next, the gain scheduling of the ancillary state feedback is obtained via solving robust pole assignment using LVI-PDNN. An optimal state trajectory is thus generated for the nominal robotic system by the MPC without various uncertainties, the ancillary state feedback control forces the state variables to be constrained within an invariant designed tube. Finally, extensive experimental results on stabilization control of the nonholonomic mobile robot are provided to verify the effectiveness of the proposed robust tube-based MPC.
Visual sensors for remote metering in public networks

New research trends in energy grids and water networks push toward ICT solutions for allowing remote metering of consumptions. In the paper, after an introduction to the European Standards on smart metering, a visual sensor thought to solve typical metering problems in water public networks is described. Particular detail is given to its hardware and software solutions and to the perspective of integration with analogous gas and electric energy metering devices.
The Risk of Securities-based Crowd-funding in China and its Preventive Measures

In recent years, securities-based crowdfunding has been developed rapidly in China. But investors are facing the risk of information asymmetry, law, financial business, operation and information security. This paper sorts the risks by using FAHP, and shows that: the degree of prominence from high to low is information asymmetry risk, law risk, financial business risk, operation risk and information security risk. Therefore, the governor should implement the system of mandatory disclosure of information, make immunity for small public issuing, ensure that the share would be resoled freely and keep circulation channels unobstructed , strengthen the construction of information security system and finally implement the investor protection system, so as to promote securities-based crowdfunding to develop in a healthy way.
Physiologic and Biochemical Effects of Immobilization on Muscle

Muscle strength rapidly declines during limb immobilization because of a decrease in muscle size and a decrease in tension per unit of muscle cross-sectional area. Muscle fatigability also increases rapidly after limb immobilization. Muscles within limbs fixed by plaster casts have (1) lower levels of resting glycogen and adenosine triphosphate (ATP), (2) a more rapid depletion of muscle glycogen and ATP during work, (3) a greater increase in lactate during work, and (4) a decreased capacity to oxidize fatty acids during work. The greatest loss of absolute muscle mass occurs at the beginning of muscle wasting with subsequent loss of muscle being exponential. A significant decrease in the rate of protein synthesis in muscles is observable at the sixth hour of limb immobilization, which most likely initiates the net loss of muscle protein. A change in the amount of either translational or elongational factor is most likely responsible for the early decrease in this rate of protein synthesis.
Reduced competitive ability in an invasive plant

One explanation for successful plant invaders is that they evolved to be more competitive. An intuitive prediction of this Evolution of Increased Competitive Ability (EICA) hypothesis never previously tested is that invasive populations should outcompete their native ancestors in a common environment. We tested this idea in a diallel competition experiment with Alliaria petiolata where offspring from native and invasive populations were grown alone or in all pairwise combinations. While without competition, there were no differences between native and invasive populations, native populations outperformed invasive ones when competing against each other. Our results contradict the EICA hypothesis and we conclude that it does not not hold for Alliaria petiolata. Instead, we formulate a new ERCA (Evolutionary Reduced Competitive Ability) hypothesis: if there is less competition in the invasive range and competitive ability involves traits that have a fitness cost, then selection might act against it, thereby reducing intraspecific interactions too.
Female Infertility and Antioxidants

Aim: Many studies have implicated oxidative stress in the pathogenesis of infertility causing diseases of the fe- male reproductive tract. The aim of this study was to review the current literature on the effects of antioxidant therapy and to elucidate whether antioxidant supplementation is useful to prevent and/or treat infertility and poor pregnancy outcomes related to various obstetric and gynecologic conditions. Methods: Review of recent publications through Pubmed and the Cochrane data base. Results: Antioxidant supplementation has been shown to improve insulin sensitivity and restore redox balance in patients with PCOS. Supplementation with RU486, Curcuma longa, melatonin, caffeic acid phenethyl ester (CAPE) and catechins may induce remission and halt disease progression in endometriosis. Selenium therapy may improve pregnancy rates in unexplained infertility. Currently there is no evidence to substantiate the use of antioxidants to prevent or treat preeclampsia. Up to 50-60% of recurrent pregnancy loss may be attributable to oxidative stress. Observational studies have confirmed a link between antioxidant-poor diet and recurrent pregnancy loss. Conclusion: Although many advances are being made in the field of antioxidants therapy, there is a need for further investigation using randomized controlled trials within a larger population to determine the efficacy and safety of antioxidant supplementation.
The Effects of Carvedilol Administration on Cardiopulmonary Resuscitation in a Rat Model of Cardiac Arrest Induced by Airway Obstruction

BACKGROUND: Carvedilol is a nonselective &bgr;-adrenoceptor and selective &agr;1-adrenoceptor blocker and is widely used in the treatment of patients with hypertensive and/or chronic heart failure because, unlike classic &bgr;-blockers, this drug has additional endothelium-dependent vasodilatory effects. We evaluated the effects of oral administration of carvedilol on cardiopulmonary resuscitation (CPR) in a rat model of cardiac arrest (CA) induced by airway obstruction. METHODS: Twenty-four rats were randomly assigned to 2 groups: control group (no medication) and treatment group (oral administration of carvedilol [10 mg/kg/d] for 5 days) (n = 12 per group). All the animals were anesthetized, and CA was induced by obstructing the airway. Three minutes after CA, the animals were revived by administering CPR. The rate of chest compressions (CCs) was 240 to 260 CCs/min and the depth of CCs was adjusted to maintain the diastolic arterial blood pressure between 25 to 30 mm Hg in both groups. Epinephrine (0.02 mg/kg) was administered after 5 minutes of CPR. No other therapy was administered before, during, or after CA. RESULTS: The time interval between airway obstruction and CA in the treatment group was significantly longer than in the control group (230 ± 27 vs 203 ± 24 seconds; P < 0.05). The rate of return of spontaneous circulation in the treatment group was significantly higher than in the control group (92% vs 50%; P < 0.05). Acidosis and increased glucose and tumor necrosis factor-&agr; concentrations in the treatment group were significantly lower than in the control group. CONCLUSIONS: The results of our study showed that rats that had been administered oral carvedilol for several days were more resistant to CA induced by airway obstruction, and when CA did occur, were more likely to be resuscitated. These findings suggest that carvedilol may prolong the safe ischemic time induced by respiratory failure.
Inhibition of Low Threshold Calcium Channels by Angiotensin II in Adrenal Glomerulosa Cells through Activation of Protein Kinase C (*)

In adrenal glomerulosa cells, low threshold voltage-activated (T-type) calcium channels play a crucial role in coupling physiological variations of extracellular potassium to aldosterone biosynthesis. Angiotensin II markedly reduced the activity of these channels by shifting their activation curve toward positive voltage values. This inhibition of the channels resulted in a marked decrease of the cytosolic free calcium concentration maintained by potassium. This effect was abolished by losartan, a specific antagonist of the angiotensin II AT1 receptor. Hormone action on T-type channels appeared to be mediated by protein kinase C because 1) it was mimicked by phorbol ester and diacylglycerol, and 2) it was significantly reduced by decreasing protein kinase C activity with specific inhibitors such as chelerythrine chloride or a pseudosubstrate of the enzyme, as well as by protein kinase C down-regulation. Similarly, protein kinase C activation reduced the cytosolic calcium response to potassium and the steroidogenic action of this agonist. Low threshold T-type calcium channels therefore appear as potential sites for the modulation of steroidogenesis by protein kinase C in adrenal glomerulosa cells.
Tax Compliance and Information Provision - A Field Experiment with Small Firms

We study a field experiment on tax compliance in Slovenia. Small accounting companies were randomly assigned to an untreated control group and two treatment groups. Companies in the first treatment group received a letter that highlighted the importance of paying taxes and informed about the likelihood of becoming subject to an audit. In the second treatment group, tax officers from the tax authorities handed out in person the same letter that companies in the first treatment group received by post. The results indicate that such letters can increase compliance, and trigger even more compliance if handed over in person. These findings are in line with the theoretical predictions that we derive to rationalize the experiment.
Subsequent anti-VEGF therapy after first-line anti-EGFR therapy improved overall survival of patients with metastatic colorectal cancer

Colorectal cancer is one of the leading causes of cancer deaths worldwide. Due to targeted therapy, overall survival (OS) of metastatic colorectal cancer (mCRC) patients has been significantly increased over the past decade. However, the best sequencing of the therapeutic agents to be used in RAS wild-type subgroup is still under research. To determine the efficacy of targeted therapy, we collected randomized controlled trials which included patients receiving anti-epidermal growth factor receptor (EGFR) monoclonal antibody as first-line therapy in RAS/KRAS wild-type mCRC. In our study, we found that OS was significantly improved by anti-vascular endothelial growth factor (VEGF) agent after first-line anti-EGFR therapy. Our results revealed that it is a sensible treatment strategy to try anti-VEGF agent after first-line combination therapy with anti-EGFR monoclonal antibody for RAS/KRAS wild-type mCRC.
Overview of Management and Functional Activities in Nigerian Banking Industry

Banks and banking has become synonymous with business management and economic development. The importance of banks to the economy ofevery nation cannot be overemphasized. It is in most cases the driver of the economy in most countries. This is because it deals with the monetary policies while the ministry of finance deals with the fiscal policies. This paper discusses the various roles of various office holders within the banking industry in Nigeria as well as the credit risks involved in the administration and management of loans. It recommends a holistic and inclusive management of both banks and credits to the economic health of the nation
Dynamic sharing of radio spectrum: a brief history

This article reviews the various approaches to dynamic sharing of spectrum that have been employed over time, identifies the costs and benefits of these approaches, and offers conclusions on the characteristics of radio services that benefit most from the use of dynamic sharing. Dynamic sharing is a powerful tool for spectrum management. It offers the opportunity for substantial efficiency gains. Modern technology, especially embedded computer controllers, makes this spectrum management technique much more viable than it was in the past. Dynamic spectrum sharing will be a valuable tool in the era of low-cost radios. It works best when the time scale of fluctuations in the use of the radio channel are small relative to license terms-that is it works better with telephone calls than with broadcast signals
Project Characteristics and Group Communication: An Investigation

Individuals working with other people as a group over a sustained period of time is the best way to design and implement systems that meet society's needs. This chapter presents a research study which examined the effects of technological complexity on project group communication. The same project teams performed three separate projects involving the development of an HTML website, the development of a local-area network (LAN), and the development of blueprints for a wide-area network (WAN). Each of the projects exposed groups to a different level of complexity. The results of the study indicated differences in group information sharing, group communication focus, and group gatekeeping activities. In each of these cases, the groups had greater communication with the less complex project task, the HTML project. The study did not find significant differences in group communication concerned with member withdrawal or group conflict.