Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing the Content Validity of a New Patient-Reported Measure of Barriers to Antiretroviral Therapy Adherence for Electronic Administration in Routine HIV Care: Proposal for a Web-Based Delphi Study

Background Adherence to lifesaving antiretroviral therapy (ART) for HIV infection remains a challenge for many patients. Routine screening for barriers to ART adherence could help make HIV care more patient-centered and prevent virologic rebound or failure. Our team is currently developing a new HIV-specific patient-reported outcome measure (PROM) of these barriers for use in Canada and France along with a digital app for its electronic administration. In our previous work, we developed the PROM’s multidimensional conceptual framework and generated 100 English items, which have been translated to French. Objective This study aims to use a Web-based Delphi to help validate and select the content of this new HIV-specific PROM, based on the perspective of anglophone and francophone patients and providers in Canada and France. Here, we present the proposal for this Delphi. Methods This modified Delphi will involve a diverse panel of patients (n=32) and providers (n=52) recruited especially from the 9 sites of the PROM development study (site locations in Canada: Montreal, Toronto, Vancouver; in France: Paris, Nantes, Clermont-Ferrand, Saint-Martin, Cayenne). Overall, 2 rounds of Web-based questionnaires will be conducted. The threshold for consensus is set at 60% and will determine which items are carried forward to the second round. Per item, 3 aspects will be rated: importance as a barrier to ART adherence, relevance for HIV care, and clarity. In both rounds, space will be available for free text comments. Overall comprehensiveness will be assessed in the second round. Results This study has undergone a methodological review by experts in patient-oriented research. It has received approval from a research ethics board of the McGill University Health Centre. It is financially supported, in part, by the Canadian Institutes of Health Research’s Strategy for Patient-Oriented Research-Quebec Support Unit (M006). As of May 21, 2019, 15 people living with HIV and 25 providers completed the first round of the Delphi (24 from Canada and 16 from France). Conclusions To our knowledge, this is the first Delphi to seek consensus on the most relevant and clinically actionable barriers to ART adherence, collecting opinions on an extensive list of barriers. Drawing on a relatively large and diverse panel of HIV patients and providers, it essentially engages key stakeholders in decision making about the PROM’s final content, helping to ensure its utility and adoption. International Registered Report Identifier (IRRID) PRR1-10.2196/12836
Preeclampsia: Effect on the Fetus and Newborn

Preeclampsia (PE) is the most common medical complication in pregnancy and a major cause of maternal and fetal morbidity and mortality. This disease is a great challenge for obstetricians because there are no effective interventions to treat or prevent it, and antenatal care involves a difficult balance between the risks for women to continue pregnancy and the risks for the baby’s early birth. Fetal complications in PE are directly related to gestational age and the severity of maternal disease and include increased rates of preterm delivery, intrauterine growth restriction, placental abruption, and perinatal death. The major complications for the newborn are related to prematurity, although the data on the morbidity and outcome for preterm infants of women who have PE are conflicting, and few studies address this issue. The pathogenesis of PE involves abnormal placentation associated with immune and vascular events that result in endothelial dysfunction and clinical manifestations of PE. This disease has been associated with imbalance in angiogenic factors and oxidative stress. Nevertheless, only a limited number of studies have been carried out on fetuses and newborns that suggest that infants born from women who have PE are exposed to increased oxidative stress. Because oxidative stress and free radicals may play roles in several neonatal diseases, a direct effect of maternal disease on neonatal outcome is expected, and further research on such neonates, in the short- and long-term, is urgently needed.
Inspection of Deep Packet Inspection in Real-time for Performance Testing: A Framework

In order for a deep packet inspection engine to be effective in matching traffic, both directions of traffic flow need to be seen by the classifier. The traffic generated by the source and the replies generated by the destination thus need to be passed through the classifier. It is therefore necessary to separate “Good traffic” from “Bad traffic” to optimize performance of communication networks and mitigate the risk imposed on these once closed computer systems. Enterprise and service provider customers develop, maintain and operate network infrastructure in order to support the applications required to perform their day to day tasks. These applications have certain requirements and expectations from the infrastructure, including access to public networks, and thus rely on quality of service (Q0S) controls to manage network traffic. QOS controls are used to ensure non-critical applications do not hamper the operation of critical ones, all the while providing fair access to all legitimate applications. QOS systems are increasingly being used as firewalls, filtering bad traffic and allowing good traffic to traverse the network without delay. The proposed system designs and develop a cost effective tool to perform deep packet inspection over real-time traffic.
Auflösungsverbessernde rekonstruktion von PET-bildern mit dem iterativen OSEM-algorithmus

Ziel: Verbesserung der raumlichen Auflosung in der Positronenemissionstomographie (PET) durch Beruck-sichtigung der Abbildungseigenschaften des Scanners bei der iterativen Bildrekonstruktion. Methodik: Alle Messungen erfolgten am Ganzkorper-PET- System ECAT EXACT HR+ im 3D-Modus. Die 3D-Sino-gramme wurden mit dem Fourier-Rebinning-Algorithmus (FORE) in 2D-Sinogramme umsortiert, so dass fur die Bildrekonstruktion 2D-Algorithmen eingesetzt wurden. Die Abbildungseigenschaften des Scanners wurden durch eine raumlich veranderliche Linienabbildungsfunktion (LSF) charakterisiert, die mit Kupfer-64-Linienquellen vermessen wurde. Diese Information wurde verwendet, um die physikalischen Prozesse, die bei der PET-Mes-sung zur Auflosungsverschlechterung fuhren, bei der 2D-Bildrekonstruktion mit dem iterativen OSEM-Algo-rithmus zu berucksichtigen. Um die Abbildungseigen-schaften des hochauflosenden OSEM-Algorithmus zu evaluieren, wurden Messungen an einem Zylinder-, dem Hotspot-Jaszczack- und dem Hoffmann-3D-Brain-Phantom sowie Patientenuntersuchungen analysiert. Ergebnisse: Die Abbildungscharakteristika des Scanners konnten durch eine Gauss-formige LSF beschrieben werden, deren Halbwertsbreite von 4,8 mm im Zentrum auf 5,5 mm im radialen Abstand von 10,5 cm zu-nimmt. Durch die Einbeziehung der LSF in die Iterations-formel konnte die raumliche Auflosung uber das be-trachtete Gesichtsfeld auf 3,0 bzw. 3,5 mm verbessert werden. Die Auswertung ergab, dass der hochauflosen-de OSEM-Algorithmus zu einer besseren Kontrastauf-losung in den Aktivitatsverteilungen fuhrt und zu einer erhohten Genauigkeit bei der Quantifizierung von Akti-vitatskonzentrationen in kleinen Strukturen, ohne dass es zu einem Anstieg des Bildrauschens oder gar zur Ausbildung von Artefakten kommt. Schlussfolgerung: Die Orts- und Kontrastauflosung von PET-Bildern kann durch den evaluierten Restaurations-algorithmus deutlich verbessert werden, was fur die Untersuchung von Patienten mit Hirnerkrankungen als auch von Kleintieren von Interesse ist.
Risk Factors of Choledocholithiasis after Distal Gastrectomy for Gastric Cancer

Citation: Asaumi Y, Sakatoku M, Hayashi S, Ohta N, Nozaki Z, et al. (2018) Risk Factors of Choledocholithiasis after Distal Gastrectomy for Gastric Cancer. Int J Surg Res Pract 5:066. doi.org/10.23937/23783397/1410066 Received: April 09, 2018: Accepted: April 19, 2018; Published: April 21, 2018 Copyright: © 2018 Asaumi Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. International Journal of Surgery Research and Practice Open Access ISSN: 2378-3397
Modeling of actuator systems using multilayer electrostrictive materials

A general model for fuel injection valves using multilayer electrostrictive materials actuators is established. Based upon finite element approach, the model describes the dynamic behaviors of the multilayer electrostrictive actuators and correlates with dynamics of other lumped-parameter components to form overall system state equations for the fuel injector. Simulations are performed for the system using LiF, RbI, and NaF electrostrictive materials with different number of layers to form the actuators.
The Association between Osteoporosis and Early Menopause following Hysterectomy

The Association Between Osteoporosis and Early Menopause Following Hysterectomy by Mia Meeyaong-Won Botkin MPH, Walden University, 2012 MS, California State University, Fullerton, 2000 BS, University of California, Los Angeles, 1998 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Health Walden University May 2016
Reconstructing Cortical Dynamics with Magnetoencephalography

The dynamics of neural information processing are complicated, and determining the sequence and mode of activation is equally important to determining which areas activate. Magnetoencephalography (MEG) and electroencephalography (EEG) noninvasively measure the electromagnetic fields directly generated by neuronal currents in the human brain. The potential to accurately localize these signals has emerged with the advent of dense, whole-head sensor arrays. Adaptive spatial filtering techniques such as beamforming are often used reconstruct the sources of MEG/EEG activity. I have developed extensions to apply beamforming to more experimental paradigms as well as a method for more accurate validation with intracranial EEG.Beamformers poorly resolve brain sources that are strongly correlated temporally with one another, as might be expected for an auditory experiment. I presented a method to reject the contribution of potentially interfering sources in a user-defined suppression region while allowing for source reconstruction at other specified regions. Performance of the algorithm was validated with data from simulations and an auditory MEG experiment.Few methods exist for localizing spectral power changes with MEG. I described a novel method that uses beamformers optimized for time-frequency source reconstruction from MEG data. The performance of the method was demonstrated with simulated sources and was also applied to real MEG data from a finger movement task. Modulations in both the beta band and, importantly, the high gamma band were revealed in sensorimotor cortex and found to be statistically significant across subjects. These results were additionally validated by intracranial EEG data from two epilepsy patients. Another compelling finding was high frequency activity (30-300 Hz) in the cerebellum.Finally, while intracranial recordings are considered the gold standard for validating noninvasive measurements, often electrode locations are not precisely known. One common method, CT-MRI coregistration, may result in a localization error of more than 10 mm. To address this, I developed a procedure to link preoperative MRIs, surgical photographs, and postimplant X-rays with projective transforms.
Por qué plantear el tratamiento con liraglutida en los pacientes con diabetes tipo 2

Liraglutide is a GLP‐1 receptor agonist indicated for the treatment of type 2 diabetes. This drug has an excellent efficacy/safety profile and differential properties, as well as beneicial effects on several parameters of beta cell function (proinsulin ratio: insulin, HOMA‐B, irst and second insulin secretion phase and maximum insulin secretion, HOMA‐IR) that equal or surpass those of its comparators. When added to monotherapy or in oral antidiabetic drug PALABRAS CLAVE
Faster Evolutionary Multi-Objective Optimization via GALE, the Geometric Active Learner

Faster Evolutionary Multi-Objective Optimization via GALE, the Geometric Active Learner by Joseph Krall Doctor of Philosophy in Computer Science West Virginia University Tim Menzies, Ph.D., Chair Goal optimization has long been a topic of great interest in computer science. The literature contains many thousands of papers that discuss methods for the search of optimal solutions to complex problems. In the case of multi-objective optimization, such a search yields iteratively improved approximations to the Pareto frontier, i.e. the set of best solutions contained along a trade-off curve of competing objectives. To approximate the Pareto frontier, one method that is ubiquitous throughout the field of optimization is stochastic search. Stochastic search engines explore solution spaces by randomly mutating candidate guesses to generate new solutions. This mutation policy is employed by the most commonly used tools (e.g. NSGA-II, SPEA2, etc.), with the goal of a) avoiding local optima, and b) expand upon diversity in the set of generated approximations. Such ”blind” mutation policies explore many sub-optimal solutions that are discarded when better solutions are found. Hence, this approach has two problems. Firstly, stochastic search can be unnecessarily computationally expensive due to evaluating an overwhelming number of candidates. Secondly, the generated approximations to the Pareto frontier are usually very large, and can be difficult to understand. To solve these two problems, a more-directed, less-stochastic approach than standard search tools is necessary. This thesis presents GALE (Geometric Active Learning). GALE is an active learner that finds approximations to the Pareto frontier by spectrally clustering candidates using a near-linear time recursive descent algorithm that iteratively divides candidates into halves (called leaves at the bottom level). Active learning in GALE selects a minimally most-informative subset of candidates by only evaluating the two-most different candidates during each descending split; hence, GALE only requires at most, 2Log2(N) evaluations per generation. The candidates of each leaf are thereafter non-stochastically mutated in the most promising directions along each piece. Those leafs are piece-wise approximations to the Pareto frontier. The experiments of this thesis lead to the following conclusion: a near-linear time recursive binary division of the decision space of candidates in a multi-objective optimization algorithm can find useful directions to mutate instances and find quality solutions much faster than traditional randomization approaches. Specifically, in comparative studies with standard methods (NSGA-II and SPEA2) applied to a variety of models, GALE required orders of magnitude fewer evaluations to find solutions. As a result, GALE can perform dramatically faster than the other methods, especially for realistic models.
Developments in Business Simulation & Experiential Learning, Volume 27, 2000 THE GLOBAL BUSINESS GAME: A STRATEGIC MANAGEMENT AND INTERNATIONAL BUSINESS SIMULATION

The millenium's newest computer-based business game will be presented by its author. The presentation will cover the rationales for the various design decisions that were made, the wide array of talents assembled by its publisher, South-Western College Publishing, and a "walking tour" of the simulation's Player and Game Administrator Windows-based applications. The Global Business Game is a very flexible simulation set in the television set manufacturing industry. Players face the challenge of working with companies that are under attack, must compete internationally if they are to survive and must provide a wider base of consumers with sets possessing greater complexity. To insure a "world class" learning experience for all players, the simulation offers the following features which can be added or subtracted from the game by the Game Administrator: • Global Focus. Competition is based in coun
Cohabitation in Great Britain: evidence from the General Household Survey

The authors examine the extent of consensual unions in Britain using data from the 1979 General Household Survey. Separate sections are included on current cohabitation cohabitation among single women cohabitation among separated and divorced women cohabitation before first marriage and inter-marital cohabitation. Some comparisons are made with the situation in other Western European countries. (ANNOTATION)
Sistem Pemantauan Kinerja Serta Pengaturan Mesin Packing Secara Otomatis Pada Pabrik Wafer Dengan Zigbee

Pada p erancangan ini dirancang sebuah sistem yang berfungsi untuk mengawasi kinerja dan mengatur operasi mesin packaging pada pabrik wafer secara otomatis dengan menggunakan zigbee sebagai media komunikasi data. Pemantauan dilakukan melalui layar komputer yang menampilkan representasi dari mesin yang dipantau. Pemantauan meliputi kuantitas produk yang dihasilkan dan keadaan mesin produksi. Pengaturan meliputi penanganan masalah ketika terjadi masalah pada saat produksi berlansung, seperti downtime pada salah satu mesin packaging supaya target produksi tercapai. Rancangan ini menampilkan keadaan mesin saat beroperasi (ON) dan saat tidak beroperasi (OFF), menjaga kestabilan suhu heater, pengaturan ulang proses produksi secara otomatis apabila terjadi downtime pada salah satu mesin. Berdasarkan hasil pengujian, rancangan ini berhasil sesuai dengan tujuan perancangan ini.
A propagation overview

Recent progress in propagation research. for wireless channels is reviewed. The emphasis is on the use of arrays for exploring the 3-dimensional character of propagation. The concept of clusters is important and appears both in indoor and outdoor environments, as well as in the delay domain. This has led to a new understanding of especially urban propagation. Arrays are also important for multiuser discrimination, and the relevant propagation aspects are discussed. MIMO systems rely heavily on a sufficient number of independent channels, which again are very dependent on angular and polarization properties of the propagation channel.
Pengembangan dan implementasi kurikulum penting untuk meningkatkan kualitas pembelajaran

Kurikulum sebagai program pengajaran suatu jenjang pendidikan dirancang oleh guru dengan cara mengorgani¬sasikan isi dan bahan pelajaran dalam bentuk dokumen. Mengacu pada dokumen pembelajaran yang telah dirancang oleh guru, pada prinsipnya implementasi kurikulum dalam bentuk pengalaman belajar harus lebih mudah dan efektif untuk dikomu-nikasikan ke berbagai pihak seperti pimpinan sekolah, pengawas sekolah, pelak¬sana dan staf pendukung lainnya. Sasaran utama pengembangan kurikulum adalah peserta didik, masyarakat, dan subjek yang akan diajarkan. Adapun model kurikulum berkaitan dengan rancangan pembelajaran yang dapat digunakan untuk menerjemahkan sesuatu ke dalam realitas, yang sifatnya lebih praktis. Oleh karena itu, rencana, ide-ide, atau gagasan-gagasan yang akan dituliskan ke dalam suatu dokumen kurikulum seyo¬gia¬nya berpegang pada acuan teknis kuri¬kulum sebagai rencana. Rencana dan ide ide diformulasikan dalam dokumen kurikulum yang selanjutnya diimplementasikan dalam kegiatan belajar mengajar. Proses implementasi kurikulum untuk semua bidang studi atau mata pelajaran selalu menggambarkan keterkaitan proses dengan, tujuan dan konten, kejelasan teori belajar, keterkaitan dengan sosial, budaya, teknologi, ketersediaan fasilitas dan alat, alokasi waktu, fleksibilitas, peran guru dan siswa, peran evaluasi dan feedback mechanism.
Nachhaltige Erweiterung der Geodateninfrastruktur für 3D-Geodaten auf Basis von CityGML - am Beispiel der EU-Umgebungslärmkartierung

Die EU-Umgebungslarmrichtlinie fordert ab 2007 fur die Schallquellen Strase, Schiene, Flugverkehr und Industrieanlage die Berechnung von Schallemissionen und deren Darstellung in Larmkarten. Hierfur werden erstmals grosflachig und landesweit Geodaten und Fachdaten in der dritten Dimension benotigt. Diese Daten mussen rasch und flexibel fur die Zustandigen der Larmkartierung bereitgestellt werden. NRW hat sich entschlossen, die Datenbereitstellung uber den Ausbau der Geodateninfrastruktur GDI NRW mit weiteren Web Services zu realisieren. Hierbei spielt das Austauschformat CityGML eine wesentliche Rolle. Hersteller von Larmsoftware und Visualisierungstools implementieren derzeit den Zugriff auf die Web Services uber CityGML.
A Logic Test to Minimize Test Data Volume By Single Cycle Access Structure

This research proposes a a logic test to minimize test data volume by single cycle access structure. It eliminates the peak power consumption problem of conventional shiftbased scan chains and reduces the activity during shift and capture cycles. This leads to more realistic circuit behavior during stuck at and atspeed tests. It enables the complete test to run at much higher frequencies equal or close to the one in functional mode. It will be shown, that a lesser number of test cycles can be achieved compared to other published solutions. The test cycle per net based on a simple test pattern generator algorithm without test pattern compression is below 1 for larger designs and is independent of the design size. Results are compared to other published solutions on ISCAS’89 net lists. The structure allows an additional onchip debugging signal visibility for each register. The method is backward compatible to full scan designs and existing test pattern generators and simulators can be used with a minor enhancement. It is shown how to combine the proposed solution with built in self test (BIST) and massive parallel scan chains.
Streptococci in Dairy Farms: Isolation, Antibiogram Pattern and Disinfectant Sensitivity

A total of 700 different samples were collected from dairy cows and their surrounding environment from different dairy farms located in Kafr El-Sheikh including; milk (150 samples from clinically suspected cases and another 150 samples from apparently healthy cows) and swabs from teats, milking machines and hands of workers as well as bedding materials (100 samples/each) for isolation and identification of Streptococcus species. It was found that 82 samples were positive for California Mastitis Test (CMT) indicative for subclinical mastitis. Also, it was found that the frequency of isolation of Streptococcus species from clinical mastitis milk samples was 44 % (66 isolate) and 37.8% (31 isolate) in milk subclinical mastitis milk samples while the frequency of isolation of Streptococcus spp. from environmental samples revealed that the highest frequency was recorded in the examined samples of bedding materials (57%) followed by milking machine swabs (43%) and teat swabs (42%) then lastly hand swabs (23%). Moreover, the biochemical identification of the obtained Streptococci clarified the presence of Str. agalactiae, Str. dysgalactiae, Str. bovis and Str. uberis with various rates. Antibiogram pattern of S. agalactiae demonstrated high level of resistance against Chloramphenicol (90%) followed by Co-Trimoxazole (78%) while the highest sensitive antibiotic was Spiramycin (72%) followed by Gentamicin (70%) while that of S. uberis demonstrated high level of resistance against Amoxicillin (78%) followed by Amoxyclav (72%) while the highest sensitive antibiotic was Spiramycin (78%) followed by Cefotaxime (64%) and Gentamicin (60%). Finally, four commercial types of disinfectant commonly used in dairy farms including Iodine, Phenol, Virkon S® and TH4; beside Rosemary (Rosmarinus officinalis) which was a herbal agent rich in phenolic compounds with high antimicrobial activity were tested against the obtained isolates of Streptococci.