Miracle-dz/UniFAR-FTUs huggingface dataset:
Lean in service industries: A literature review

Lean service is an amalgamation of tools and practices which, if applied appropriately, would definitely improve the existing quality of operations and ensure the generation of a large amount of favourable financial and economic outcomes and improve the behaviour of the workforce. As a result, it assumes of great significance in the fiercely competitive modern world. This article presents a comprehensive bibliographic study about the various lean service practices through a variety of approaches like service improvement, manufacturing, supply chain, market and retailing approaches, etc. Thus it gives a clear view on how the lean services are implemented in various sectors and the contribution of lean service towards improving the quality in the services provided while reducing the costs.
Designing Caregiver-Implemented Shared-Reading Interventions to Overcome Implementation Barriers.

PURPOSE This study presents an application of the theoretical domains framework (TDF; Michie et al., 2005), an integrative framework drawing on behavior-change theories, to speech-language pathology. METHODS A multistep procedure was used to identify barriers affecting caregivers' implementation of shared-reading interventions with their children with language impairment (LI). The authors examined caregiver-level data corresponding to implementation issues from two randomized controlled trials and mapped these to domains in the TDF as well as empirically validated behavior-change techniques. RESULTS Four barriers to implementation were identified as potentially affecting caregivers' implementation: time pressures, reading difficulties, discomfort with reading, and lack of awareness of benefits. These were mapped to 3 TDF domains: intentions, beliefs about capabilities, and skills. In turn, 4 behavior-change techniques were identified as potential vehicles for affecting these domains: reward, feedback, model, and encourage. An ongoing study is described that is determining the effects of these techniques for improving caregivers' implementation of a shared-reading intervention. CONCLUSIONS A description of the steps to identifying barriers to implementation, in conjunction with an ongoing experiment that will explicitly determine whether behavior-change techniques affect these barriers, provides a model for how implementation science can be used to identify and overcome implementation barriers in the treatment of communication disorders.
Draft Genome Sequence of Lutibaculum baratangense Strain AMV1T, Isolated from a Mud Volcano in Andamans, India

ABSTRACT The 4.3-Mb genome of Lutibaculum baratangense strain AMV1T, isolated from a soil sample collected from a mud volcano in Andamans, India, is reported. The draft genome of strain Lutibaculum baratangense AMV1T consists of 4,300,776 bp with a G+C content of 66.93 mol% and 4,198 predicted coding regions, including 56 RNAs.
Antagonist‐induced supersensitivity of mGlu1 receptor signalling in cerebellar granule cells

We investigated the effect of 24 h sustained treatment with the mGlu1 receptor antagonist CPCCOEt on mGlu1 receptor signalling in primary cultures of rat cerebellar granule cells. In the absence of ionotropic glutamate (iGlu) blockers, the maximal inositol phosphate (IP) response (Emax) but not the potency of glutamate was significantly increased when cells were pre‐exposed for 24 h with CPCCOEt. When the contribution of iGlu receptors to the glutamate‐induced IP response was eliminated with the use of DNQX, the Emax was again increased but also the concentration eliciting 50% of the maximal glutamate stimulus was significantly decreased. In the absence of iGlu receptor inhibitors, the Emax of quisqualate, which likely mediates IP accumulation only via the mGlu1 receptor, was significantly increased in CPCCOEt‐pretreated cells. Also, less quisqualate was needed to reach the same IP effect. The potency of R193845, a selective mGlu1 receptor antagonist, was significantly decreased in antagonist‐pretreated cells. These findings demonstrate that 24 h sustained antagonist treatment can render mGlu1 receptors in neurons supersensitive to agonists, with a concomitant decrease in the effectiveness of antagonists.
Efficiency in goods distribution collaboration in cities - SAMLIC

The number of zones for unloading goods in the city centre is often small compared to the number of delivery addresses and carriers. The attendant phenomenon is congestion and its subsequent costs. One way to reduce these effects is to implement retail consolidation centres. Some trials have been carried out on urban distribution centres and a few implementations have been made. More research and knowledge is still needed. The SAMLIC project is one contribution to increase the knowledge in this field about urban distribution. A local network for Linkoping freight forwarders took the initiative to create an economically and logistically efficient system. During a nine-week trial period in the spring of 2004, coordinated distribution to the centre of Linkoping was carried out. Three freight forwarders took part in this project. The trial shows that the number of lorries needed decreased by a third, the total time for the distribution by a fifth and the total driving distance in the centre by about fifty per cent. The following paper describes this trail and an implementation proposal as well as the process of trying to implement it.
The OMERACT filter for Outcome Measures in Rheumatology.

198 It is of note that the OMERACT process has been emulated by 2 other independent groups: one in the field of chronic juvenile arthritis5, and one in ankylosing spondylitis6. The former first developed a core set followed by response criteria, closely mimicking the process of the American College of Rheumatology and OMERACT for adult rheumatoid arthritis. The latter initially formulated a core set for ankylosing spondylitis, but has since decided to bring their process under the OMERACT umbrella.
Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 Development

The development of Th subset is accompanied by subset-specific chromatin remodeling of cytokine gene loci. In this study, we show that the C-terminal, but not the N-terminal zinc finger (N-finger) of GATA-3 mediates the association with the IL-4/IL-13 intergenic DNase I hypersensitive site and the induction of an extended DNase I hypersensitivity on the IL-4/IL-13 locus. Consistently, deletion of the transactivation domains or the C-finger, but not the N-finger, abrogated the induction of IL-4 and IL-13 as well as the down-regulation of IFN-γ. In contrast, the N-finger of GATA-3 was indispensable for the binding to the IL-5 promoter and the induction of IL-5. The selective use of the N-finger may underlie the differential roles of GATA-3 in the induction of IL-4, IL-13, and IL-5.
Extending the reach of microprocessors: column and curious caching

This thesis proposes column caching and curious caching, two mechanisms that enable caches to be dynamically customized, improving performtance and resource control and enabling novel functionality. Column caching provides the ability to partition a cache between address regions while curious caching provides the ability for devices other than the master to insert data into the cache. Column and curious caching provide simple, controlled ways to dynamically change the traditionally static replacement policy that treats all memory and cache locations the same. These mechanisms were conceived during the design of START-VOYAGER, a highperformance parallel system. That effort demonstrated how current memory hierarchies and bus protocols interfere with fast communication. Though the mechanisms were originally developed for communciation, they are surprisingly useful elsewhere. For example, column/curious caching can minimize pollution, reduce miss rates, improve multitasking/multithreading performance, reduce or eliminate read latencies and implement new functionalities such as bus-accessal$1e SRAM within the cache. This thesis motivates column and curious caching by high-performance communciation, evaluates these adaptive mechanisms for communication and other uses and proposes various implementations designed for different constraints. It demonstrates how these simple mechanisms can enable substantial performance improvements and support a wide range of additional functionality. Thesis Supervisor: Arvind Title: Professor of Computer Science Thesis Supervisor: Larry Rudolph Title: Principal Research Scientist
Manual Response Set in a Stroop-like Task Involving Categorization of English and Japanese Words Indicates a Common Semantic Representation

The present study examined the semantic representation for English and Japanese words. A previous study using the interlingual word categorization showed Japanese words affected the semantic processing of English words, but English words did not affect the semantic processing of Japanese words. The present study tested the interlingual word categorization by a manual response instead of the vocal response. Analysis showed English words also affected the semantic processing of Japanese words. The common semantic representation for English and Japanese words was discussed.
Long Noncoding RNA H19-Derived miR-675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells

The lncRNA H19 and its mature product miR-675 have recently been shown to be upregulated and promote the progression of gastric cancer. However, the detailed function and underlying molecular mechanism of H19/miR-675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that H19 depended on miR-675 to enhance the proliferation and invasion of gastric cancer AGS cells, and the expression of miR-675 was positively correlated with H19 in patients with gastric cancer. Subsequently, the tumor-suppressor runt domain transcription factor 1 (RUNX1) was confirmed to be a downstream molecule of H19/miR-675 axis, since overexpression of H19 or miR-675 significantly decreased RUNX1 expression in AGS cells, and knockdown of H19 or miR-675 enhanced RUNX1 expression. More importantly, a series of assays further demonstrated that introduction of RUNX1 abrogated H19/miR-675-induced Akt/mTOR pathway activation and the following cellular proliferation and invasion of AGS cells. To our knowledge, this is the time to demonstrate that RUNX1 serves as a link between H19/miR-675 axis and Akt/mTOR signaling and is a pivotal mediator in gastric cancer progression induced by H19/miR-675. Thus, our study provides important clues for understanding the key roles of lncRNA-miRNA functional network and identifying new therapeutic targets for gastric cancer.
Transmission of Escherichia coli O157:H7 infection in Minnesota child day-care facilities.

OBJECTIVE Escherichia coli O157:H7 infection can cause hemorrhagic colitis and hemolytic uremic syndrome. Since 1988 the Minnesota Department of Health has carried out surveillance for this infection. To assess the occurrence of person-to-person transmission within day-care facilities, we investigated facilities where an infected child attended after onset of symptoms. DESIGN Parents of children less than 5 years old with E coli O157:H7 infection were interviewed from July 1988 through December 1989. If the child attended day care after onset, stool cultures were obtained from other children in attendance and their parents were interviewed. If there was presumptive evidence of ongoing E coli O157:H7 transmission in a facility, all preschool children were excluded from attending day-care facilities until two consecutive stool cultures were negative. RESULTS Sixty-eight cases of E coli O157:H7 infection were identified in Minnesota during the 18-month period, including 29 cases identified through investigations at nine day-care facilities. There was evidence of person-to-person transmission in all nine facilities. The median number of infected children per facility was two (range, two to 18), and the median attack rate was 22% (range, 3% to 38%). The median age of the primary case at each facility was 26 months (range, 12 to 59 months). There was no evidence of further transmission at facilities where children were temporarily excluded until two consecutive stool cultures were negative. CONCLUSION Person-to-person transmission of E coli O157:H7 is common when infected preschool children attend day care while symptomatic. The number of unrecognized day-care outbreaks in the United States may be substantial due to the lack of routine testing for this pathogen in stool cultures, the absence of public health surveillance in many regions, and incomplete follow-up of infected children. Temporary exclusion of all children was an effective control strategy in this population, but additional investigations are needed to determine the optimal intervention.
Using ABM in managing territorial health services: the “home-care” case in Tuscan Health System

In recent years in Italy, as in other European countries, profound changes have been introduced in health care at both the central and the regional levels. Most of them were oriented towards a shift from “hospital-centred” healthcare to healthcare based more on territorial services. This transition pursues two objectives: giving more effective responses to citizens’ needs and reducing public health expenditure. Changes that involve organizational structure must also be carried out with the introduction of measurement tools that can help in planning and can control the changes. Starting from the experiences of the healthcare system of the Tuscan Region of Italy, the paper aims to provide an experience of the ABM approach to measure both output and efficiency of territorial health services. Activity Based Management provides an appropriate method to examine territorial activities and to meet the fact-finding needs of national and regional policy, by considering the issues indicated by the territorial managers of the Tuscan healthcare system and the regional and national experiences in recent years. ABM focuses on managing activities as the route to improving value for users and for the local healthcare unit; this is accomplished by the measurement of activities and resources that determine the costs and performance of territorial services. This approach requires organization and integration of sets of data belonging to different systems such as financial and operational systems. The ABM model is complex but it can be used by policy makers for strategic perspective and for continuous improvement. Moreover, ABM meets managers’ demands, as the Tuscan territorial managers have confirmed in interviews. On the basis of experience obtained in territorial long term homecare , the paper underscores the principal issues arising from the process of conducting an ABM project in territorial health services through strong involvement of healthcare workers. The paper also presents the main outputs achieved. JEL Classification: I10, I18
Power-law link strength distribution in paper cocitation networks

A network is constructed by nodes and links, thus the node degree and the link strength appear as underlying quantities in network analysis. While the power‐law distribution of node degrees is verified as a basic feature of numerous real networks, we investigate whether the link strengths follow the power‐law distribution in weighted networks. After testing 12 different paper cocitation networks with 2 methods, fitting in double‐log scales and the Kolmogorov‐Smirnov test (K‐S test), we observe that, in most cases, the link strengths also follow the approximate power‐law distribution. The results suggest that the power‐law type distribution could emerge not only in nodes and informational entities, but also in links and informational connections.
Microfluidic valves based on TiO2 coating with tunable surface wettability between super hydrophilic and super hydrophobic

A new simple microfluidic valve, which utilizes titanium dioxide (TiO2) nanoparticles tunable surface wettability between super hydrophilic and super hydrophobic to switch the valve on/off, is presented in this paper. TiO2 nanoparticals are coated using liquid phase deposition (LPD) technique in the selected areas of silicon microchannels. After coating, a fresh TiO2 film is super hydrophilic, and liquid can flow over the TiO2 coated channel easily due to the capillary (valve open). After baking the channel covered with a PDMS film at 200 °C, the contact angle of the TiO2 film increases to 154 degree quickly in 10 minutes, resulting in a stop of liquid flow at the TiO2 film (valve closed). When the TiO2 film is exposed to a UV illumination, the film becomes super hydrophilic, and the valve is open again. The switch duration of the microfluidic valve between on and off status is less than 15 minutes. This type of microfluidic valve provides potential applications to microfluidic systems, especially the lab-on-chip systems.
Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors

One hope to maintain the benefits of antiviral therapy against the human immunodeficiency virus type 1 (HIV-1), despite the development of resistance, is the possibility that resistant variants will show decreased viral fitness. To study this possibility, HIV-1 variants showing high-level resistance (up to 1,500-fold) to the substrate analog protease inhibitors BILA 1906 BS and BILA 2185 BS have been characterized. Active-site mutations V32I and I84V/A were consistently observed in the protease of highly resistant viruses, along with up to six other mutations. In vitro studies with recombinant mutant proteases demonstrated that these mutations resulted in up to 10(4)-fold increases in the Ki values toward BILA 1906 BS and BILA 2185 BS and a concomitant 2,200-fold decrease in catalytic efficiency of the enzymes toward a synthetic substrate. When introduced into viral molecular clones, the protease mutations impaired polyprotein processing, consistent with a decrease in enzyme activity in virions. Despite these observations, however, most mutations had little effect on viral replication except when the active-site mutations V32I and I84V/A were coexpressed in the protease. The latter combinations not only conferred a significant growth reduction of viral clones on peripheral blood mononuclear cells but also caused the complete disappearance of mutated clones when cocultured with wild-type virus on T-cell lines. Furthermore, the double nucleotide mutation I84A rapidly reverted to I84V upon drug removal, confirming its impact on viral fitness. Therefore, high-level resistance to protease inhibitors can be associated with impaired viral fitness, suggesting that antiviral therapies with such inhibitors may maintain some clinical benefits.
Mobile teledermatology is here to stay

1 Visser MJ, Verberk MM, van Dijk FJ et al. Wet work and hand eczema in apprentice nurses; part I of a prospective cohort study. Contact Dermatitis 2014; 70:44–55. 2 Apfelbacher CJ, Funke U, Radulescu M, Diepgen TL. Determinants of current hand eczema: results from case–control studies nested in the PACO follow-up study (PACO II). Contact Dermatitis 2010; 62:363–70. 3 Lysdal SH, Johansen JD, Flyvholm MA, Søsted H. A quantification of occupational skin exposures and the use of protective gloves among hairdressers in Denmark. Contact Dermatitis 2012; 66:323–34. 4 Committee on Hazardous Substances. TRGS 401. Risks resulting from skin contact – identification, assessment, measures. Available at: http://www.baua. de/en/Topics-from-A-to-Z/Hazardous-Substances/ TRGS/pdf/TRGS-401.pdf (last accessed 6 January 2015). 5 Weistenhofer W, Wacker M, Bernet F et al. Occlusive gloves and skin conditions: is there a problem? Results of a cross-sectional study in a semiconductor company. Br J Dermatol 2015; 172:1058– 65. 6 Weistenh€ofer W, Baumeister T, Drexler H, K€ utting B. How to quantify skin impairment in primary and secondary prevention? HEROS: a proposal of a hand eczema score for occupational screenings Br J Dermatol 2011; 164:807–13.
Effects of sequential bouts of resistance exercise on androgen receptor expression.

PURPOSE Increased serum testosterone (TST) occurs in response to resistance exercise and is associated with increased muscle mass. However, the effects of elevated TST and sequential resistance exercise bouts on androgen receptor (AR) expression in humans are not well known. This study examined three sequential bouts of heavy-resistance exercise on serum total TST, sex hormone-binding globulin (SHBG) and free androgen index (FAI), skeletal muscle AR mRNA and protein expression, and myofibrillar protein content. METHODS Eighteen untrained males were randomly assigned to either a resistance-training [RST (N = 9)] or control group [CON (N = 9)]. RST performed three lower-body resistance exercise bouts, each separated by 48 h. At each exercise bout, RST performed three sets of 8-10 repetitions at 75-80% one-repetition maximum using the squat, leg press, and leg extension exercises, respectively, whereas CON performed no resistance exercise. Muscle biopsies were obtained immediately before the first exercise bout and 48 h after each of the three bouts, whereas blood samples were obtained immediately before, immediately after, and 30 min after each bout. Data were analyzed with two-way ANOVA and bivariate correlations. RESULTS Serum TST and FAI were significantly increased after each exercise bout (P < 0.05); however, there were no significant changes for SHBG. AR mRNA and protein were significantly increased (P < 0.05) after the second and third exercise bouts, respectively, and were significantly correlated to TST and FAI (P < 0.05). Myofibrillar protein increased after the third bout (P < 0.05). CONCLUSIONS Three sequential bouts of heavy resistance exercise increases serum TST and are effective at up-regulating AR mRNA and protein expression that appears to correspond to subsequent increases in myofibrillar protein.