Miracle-dz/UniFAR-FTUs huggingface dataset:
Hydrocolonic sonography for evaluating inflammatory bowel disease.

OBJECTIVE The purpose of our study was to compare the usefulness of hydrocolonic sonography and (99m)Tc-hexamethylpropyleneamine oxime (HMPAO)--labeled leukocyte scintigraphy in the examination of patients with inflammatory bowel disease, using precise sonographic criteria of bowel involvement. SUBJECTS AND METHODS Sixty-eight consecutive patients with active inflammatory bowel disease (34 ulcerative colitis and 34 Crohn's disease), 12 with inactive inflammatory bowel disease, and 10 control subjects were prospectively studied. Patients with active disease underwent clinical assessment, hydrocolonic sonography, scintigraphy, and colonoscopy within 72 hr, whereas patients with inactive disease and control subjects underwent clinical examination and hydrocolonic sonography. RESULTS Involvement of a colonic segment by active inflammatory bowel disease was best defined by mucosal thickness greater than 1.5 mm, bowel wall thickness greater than 4 mm, mucosal irregularity, or the absence of haustra; and involvement of the terminal ileum by bowel wall thickness greater than 4 mm. Using these criteria, hydrocolonic sonography had 100% sensitivity for identifying patients with active inflammatory bowel disease and a greater overall accuracy (87%) than scintigraphy (77%) in the assessment of disease extension. In addition, strong correlation was shown between a hydrocolonic sonography activity index and clinical and endoscopic activity indexes. CONCLUSION This prospective study provides precise sonographic criteria for the definition of bowel involvement by active inflammatory bowel disease. Hydrocolonic sonography has a greater accuracy than scintigraphy for assessing disease extension and activity. Therefore, hydrocolonic sonography should be considered a first-choice technique to complete the study of inflammatory bowel disease after confirmation of the diagnosis by histology.
Role of Rb Family in the Epigenetic Definition of Chromatin

Epigenetic changes can influence a variety of cellular processes from regulation of gene transcription to proper chromosome segregation. The molecular activities that dictate the assembly, maintenance and regulation of chromatin structure are beginning to be identified. A recent study demonstrates that the Rb family of tumour suppressors plays a major role in global chromatin structure. In addition to the well-known function of Rb family inducing a repressive chromatin state around euchromatic promoters, Rb proteins have a direct role in the assembly of pericentric and telomeric heterochromatin domains. In particular, the Rb family maintains histone 4 lysine 20 tri-methylation (H4K20) at these constitutive heterochromatin domains. Lack of the Rb family results in decreased H4K20 tri-methylation, coincidental with chromosome segregation defects and abnormal telomere elongation, two processes frequently altered in human cancer. Maintenance of heterochromatic domains, such as those of centromeres and telomeres, may represent a novel tumour suppressor function for the Rb family by ensuing genomic stability.
Judgments of slant on the basis of foreshortening.

By analogy with Stavrianos' (1945) finding for linear perspective, it was proposed that the effectiveness of foreshortening as a slant cue would increase as a function of visual angle. Surfaces of vertical lines slanted around a vertical axis were monocularly viewed at three horizontal visual angles and four angles of slant. An adjustment method was used to record apparent slant. An analysis of variance showed significant F ratios for visual angle and angle of slant thus supporting the hypothesis that increasing visual angle increases the effectiveness of slant judgments. However, subjects' verbal reports indicated that slant may not be perceived when only foreshortening is available as a cue.
Linkage limits the power of natural selection in Drosophila

Population genetic theory shows that the efficacy of natural selection is limited by linkage—selection at one site interferes with selection at linked sites. Such interference slows adaptation in asexual genomes and may explain the evolutionary advantage of sex. Here, we test for two signatures of constraint caused by linkage in a sexual genome, by using sequence data from 255 Drosophila melanogaster and Drosophila simulans loci. We find that (i) the rate of protein adaptation is reduced in regions of low recombination, and (ii) evolution at strongly selected amino acid sites interferes with optimal codon usage at weakly selected, tightly linked synonymous sites. Together these findings suggest that linkage limits the rate and degree of adaptation even in recombining genomes.
Involvement of Cholecystokinin in Food Intake: III. Oestradiol Potentiates the Inhibitory Effect of Cholecystokinin Octapeptide on Food Intake in Ovariectomized Rats

The role of Cholecystokinin in a model of hypophagia, oestradiol‐treated Ovariectomized rats, was investigated. Implantation of oestradiol‐filled constant‐release implants in rats made obese by ovariectomy potentiated the inhibitory effect of intraperitoneal injection of Cholecystokinin octapeptide on food intake after 24 h of food deprivation. The alterations in the concentration of Cholecystokinin in pjasma and of cholecystokinin‐like immunoreactivity in cerebrospinal fluid produced by deprivation of food for 24 h and subsequent food intake for 1 h were unaffected by the oestradiol treatment as was the amount of food consumed during 1 h. Oestradiol‐treated rats deprived of food for 6 h, however, consumed less food during a 15‐min test than controls. Treatment with oestradiol blunted the decrease in the concentration of cholecystokinin‐like immunoreactivity in the cerebrospinal fluid in response to 6 h of food deprivation. No alterations in the concentration of Cholecystokinin in plasma occurred after this period of food deprivation and subsequent feeding during 15 min in either oestradiol‐treated or control rats. Thus, treatment with oestradiol enhances responsivity to exogenous Cholecystokinin octapeptide and changes the response of endogenous levels of cholecystokinin‐like immunoreactivity in the cerebrospinal fluid to a short period of food deprivation. It is suggested that these effects are caused by an action of oestradiol on Cholecystokinin pathways in the brain. The results support the suggestion that hunger in the rat is inversely related to the decrease in the concentration of cholecystokinin‐like immunoreactivity in the cerebrospinal fluid.
Test Cases Selection Based on Source Code Features Extraction

Extracting valuable information from source code automatically was the subject of many research papers. Such information can be used for document traceability, concept or feature extraction, etc. In this paper, we used an Information Retrieval (IR) technique: Latent Semantic Indexing (LSI) for the automatic extraction of source code concepts for the purpose of test cases’ reduction. We used and updated the open source FLAT Eclipse add on to try several code stemming approaches. The goal is to check the best approach to extract code concepts that can improve the process of test cases’ selection or reduction.
Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading

ABSTRACT Skeletal muscle atrophy caused by unloading is characterized by both decreased responsiveness to myogenic growth factors (e.g., insulin-like growth factor 1 [IGF-1] and insulin) and increased proteolysis. Here, we show that unloading stress resulted in skeletal muscle atrophy through the induction and activation of the ubiquitin ligase Cbl-b. Upon induction, Cbl-b interacted with and degraded the IGF-1 signaling intermediate IRS-1. In turn, the loss of IRS-1 activated the FOXO3-dependent induction of atrogin-1/MAFbx, a dominant mediator of proteolysis in atrophic muscle. Cbl-b-deficient mice were resistant to unloading-induced atrophy and the loss of muscle function. Furthermore, a pentapeptide mimetic of tyrosine608-phosphorylated IRS-1 inhibited Cbl-b-mediated IRS-1 ubiquitination and strongly decreased the Cbl-b-mediated induction of atrogin-1/MAFbx. Our results indicate that the Cbl-b-dependent destruction of IRS-1 is a critical dual mediator of both increased protein degradation and reduced protein synthesis observed in unloading-induced muscle atrophy. The inhibition of Cbl-b-mediated ubiquitination may be a new therapeutic strategy for unloading-mediated muscle atrophy.
Expression of bFGF and TGF-beta 2 in experimental myopia in chicks.

PURPOSE To determine factors that control ocular enlargement in experimental form-deprivation myopia and to clarify the mechanism of form-deprivation myopia. METHODS After the left eyes of 20 chicks were monocularly occluded for 2 weeks, protein, basic fibroblast growth factor (bFGF) and transforming growth factor (TGF)-beta 2 contents in samples of constant area (circular button, diameter = 8.5 mm) in the retina-retinal pigment epithelium (RPE)-choroid and the sclera in the posterior region of control and myopic eyes were determined by enzyme-linked immunosorbent assay. RESULTS The bFGF content (per circular button) and bFGF concentration (per mg protein) were significantly lower in the sclera in the posterior region of the myopic eyes than in control eyes. The bFGF content and concentration were similar in the retina-RPE-choroid in myopic and control eyes. The TGF-beta 2 content and concentration were significantly higher in myopic eyes in both the retina-RPE-choroid and the sclera (P < 0.05). CONCLUSIONS These results are consistent with the possibility that bFGF and TGF-beta 2 regulate ocular enlargement or respond to myopiagenic mechanisms in form-deprivation myopia.
High‐dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study

Amyloid light chain (AL) amyloidosis is the result of a clonal plasma cell expansion, in which monoclonal light chains transform to amyloid deposit in various tissues and can lead to organ dysfunction and organ failure. The median survival of patients with AL amyloidosis without therapy is 10–14 months. With high‐dose melphalan (HDM) and autologous stem cell transplantation (ASCT), haematological and clinical remission rates of up to 50% of treated patients have been reported from phase II studies. HDM followed by ASCT appears to prolong survival in patients, if haematological remission can be reached. In this phase II study, we evaluated vincristine, adriamycin and dexamethasone (VAD) as induction chemotherapy prior to stem cell mobilization and HDM with ASCT. The regimen was, in general, feasible in patients with AL amyloidosis, but VAD chemotherapy had a considerable World Health Organization (WHO) grade III–IV toxicity (25%) and mortality (7%) rate. VAD pretreatment did not interfere with stem cell mobilization and HDM with ASCT was possible in 86% of patients. The overall treatment efficacy was comparable with reported results of HDM and ASCT without preceding chemotherapy. We could not show an additional benefit of VAD induction in terms of increasing haematological response rate; however the 13% mortality rate after HDM and ASCT in our series was lower than the previous report.
Predicting the Potential for Risky Behavior Among Those "Too Young" to Drink as the Result of Appealing Advertising

A survey of 273 children in Washington state used a predrinking behavior index as a behavioral outcome to assess media effects on precursors to drinking among children for whom alcohol consumption is not yet occurring. It also examined age trends in relevant beliefs and behaviors. Perceptions of advertising desirability, the extent to which it seemed appealing, increased steadily from third to ninth grade, whereas identification with portrayals, the degree to which individuals wanted to emulate portrayals, leveled off after sixth grade. Expectancies, positive social benefits perceived to be associated with drinking alcohol, also increased with age, particularly between sixth and ninth grade. When demographics and grade level were controlled, desirability predicted identification, and both predicted expectancies, which is consistent with media decision-making theory. Expectancies correlated with alcohol predrinking behavior, and expectancies predicted risky behavior, with demographics and grade level controlled. Predrinking behavior and reported risky behavior were correlated. The results provide cross-sectional support for the view that beliefs and desires developing by third grade prime children for future decisions regarding substance use.
Distributed parametric amplification at 1.3 µm in 25-km single-mode fiber

Distributed parametric amplification (DPA) at 1.3-μm wavelength range is experimentally demonstrated, the first time to the best of our knowledge, in a spool of 25-km SMF. Multi-channel amplification is achieved with ~ 3-dB on-off gain.
HLA-DRB1*01 association with Henoch-Schönlein purpura in patients from northwest Spain.

OBJECTIVE To examine the HLA-DRB1 phenotypes of patients with Henoch-Schönlein purpura (HSP) and determine if associations exist with disease susceptibility, clinical heterogeneity, or severe systemic complications. METHODS A retrospective study was performed on an unselected population of patients from Northwest Spain with HSP classified according to proposed criteria. Patients were included in this study if they had at least one year of followup. Fifty Caucasian patients (25 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-DRB1 genotyped from DNA using molecular based methods. RESULTS During the course of the disease, renal manifestations, especially hematuria, and severe gastrointestinal (GI) manifestations (bowel angina or GI bleeding) were observed in more than 60% of the patients. Twenty percent of patients had persistent renal involvement (renal sequelae). Patients with HSP had a significantly higher frequency of the HLA-DRB1*01 phenotype compared to matched controls. The HLA-DRB1*07 phenotype was also significantly reduced compared with controls. Patients with severe GI manifestations or with persistent renal involvement did not exhibit any specific HLA-DRB1 association other than the underlying association with HLA-DRB1*01. CONCLUSION HSP in a population from Northwest Spain is significantly associated with HLA-DRB1*01.
Bias in estimated online leaf carbon isotope discrimination due to woody tissues

Branch or shoot chamber measurements integrate over both foliar and woody tissue carbon dioxide (CO2) fluxes and their associated influences on the carbon isotopic composition of atmospheric/headspace CO2. Here, we quantified the bias introduced by woody tissue carbon isotope fluxes on apparent leaf 13C discrimination (Δ13Capparent) estimates, using laser spectroscopy under controlled conditions. CO2 efflux from woody tissues of defoliated beech saplings in the dark was strongly related to temperature (R2 = 0.78), which served as the basis to model light-dependent woody tissue photosynthesis (R2 = 0.72). We then quantified the contributions of leaf and woody tissues to leaf Δ13Capparent of foliated beech saplings in the light. Unbiased foliar Δ13C was 1.1 to 4.9 ‰ lower than leaf Δ13Capparent, depending on photosynthetic rates of woody tissues. Therefore, we strongly recommend accounting for isotope-related bias due to woody tissues when estimating leaf Δ13Capparent based on branch or shoot chamber measurements.
Mandarin Prosodic Phrase Prediction based on Syntactic Trees

Prosodic phrases (PPs) are important for Mandarin Text-To-Speech systems. Most of the existing PP detection methods need large manually annotated corpora to learn the models. In this paper, we propose a rule based method to predict the PP boundaries employing the syntactic information of a sentence. The method is based on the observation that a prosodic phrase is a meaningful segment of a sentence with length restrictions. A syntactic structure allows to segment a sentence according to grammars. We add some length restrictions to the segmentations to predict the PP boundaries. An F-Score of 0.693 was obtained in the experiments, which is about 0.02 higher than the one got by a Conditional Random Field based method.
REM behavior disorder and excessive daytime somnolence in Machado–Joseph disease (SCA‐3)

We reported previously that behavior suggestive of rapid eye movement sleep behavior disorder (RBD) was markedly increased in a small population of SCA‐3 patients. We, therefore, asked patients and nonpatient attendees at an SCA‐3 annual clinic to complete a questionnaire soliciting RBD‐like behavior. Our results support the previous observation that RBD‐like behaviors are significantly increased in SCA‐3. © 2003 Movement Disorder Society
AN INTEGRATED MICROFLUIDIC PLATFORM FOR NEGATIVE SELECTION AND ENRICHMENT OF CIRCULATING TUMOR CELLS

Circulating tumor cells (CTCs) are indicators for cancer diagnosis and prognosis. In this work, a new integrated microfluidic system capable of un-biased and sensitive “negative” enrichment of CTCs was developed. By using anti-human CD45 coated magnetic beads, leukocytes were removed by external magnetic force, leaving behind an enriched target cell population. The results demonstrated that the developed chip was capable of performing CTC negative enrichment with comparable performance as the conventional benchtop method while offering significant advantages in rapid incubation and potential for automation, suggesting the developed chip is promising for standardized CTC isolation platform.
Association and linkage of juvenile MS with HLA-DR2(15) in Russians

Abstract—The aim of this study was to determine the role of the HLA-DRB1 gene [6p21] in susceptibility to juvenile MS (JMS) (age at onset ≤15 years) of children of Russian descent. Association of DR2(15) with JMS has been found by the comparison of patients with JMS with both unrelated and affected family-based healthy controls. The linkage of DR2(15) with JMS was shown by transmission disequilibrium test. There were no significant differences in the frequencies of DRB1 alleles and genotypes between 56 patients with JMS and 234 patients with MS with age at onset ≥16 years.
基于Net Micro Framework框架的物联网网关的研究

物联网网关在物联网时代扮演着非常重要的角色，本文对基于NetMicroFramework平台的多协议及网络自适应的物联网网关系统进行了研究，对实现感知网络与传统通信网络连接和不同类型感知网络之间的协议转换的物联网网关功能进行了分析。
Evaluation of process variability on current for nanotechnologies devices

The continuous shrinking of devices has introduced new challenges to integrated circuit design, mainly to deal with the parametric variations in process parameters. This paper presents an evaluation of the process variability on the current Ids of nanotechnologies devices, individually and simultaneously, taking into account the correlation among them. The results show that the deviation from mean value is quite significant ≈ 16% for high performance models. The variation of L has the dominant effect on the overall variation of the device in high performance models while the dominant effect on the overall variation of the device in low power models still being due to Vth variations. Lastly, the effect of process parameter variations deteriorates with technology scaling, with a considerable increase in the deviation from the 22 nm to 16 nm technology.
An eight-channel add-drop filter using vertically coupled microring resonators over a cross grid

An eight-channel add-drop cross-grid vertically coupled microring resonator (VCMRR) filter is proposed and demonstrated. The cross grid comprises a grid-like array of buried channel waveguides which perpendicularly cross through each other, VCMRRs at each of the cross-grid nodes serve as the wavelength selective add-drop filters. Measured crosstalk levels at the crossings are typically less than -30 dB. Rings with a nominal radius of 10 /spl mu/m are used to achieve a free-spectral range of 20 nm and optical bandwidths of 1 nm, while changes of the radii in increments of 50 nm lead to a nominal channel spacing of 5.7 nm.
The research on space vector control of induction motor system based on rotor field orientation

In this paper, the mathematical model of induction motor based on rotor field orientation in synchronous frame is introduced. Based on this, the decoupling of stator voltage is implemented using the feed forward decoupling current controller. The problem in the accuracy of flux estimation is settled using voltage model and current model flux mixing observer. Torque regulator and speed regulator are designed to ensure the precise of current amplitude, phase tracking and accurate control of speed through dual closed-loop control of current and speed loop. The SVPWM control strategy is applied to control induction motor. The simulation results show that the proposed scheme is feasible and the space vector control system has a fast dynamic respond.
An Architecture for Visualisation and Interactive Analysis of Proteins

Data sets in the biological domain are often semantically complex and difficult to integrate and visualise. Converting between the file formats required by interactive analysis tools and those used by the global databases is a costly and error prone process. This paper describes a data model designed to enable efficient rendering of and interaction with biological data, and two demonstrator applications from different fields of protein analysis that provide co-ordinated views of data held in the underlying model
Individual Student Characteristics: Can Any Be Predictors Of Success In Online Classes?

Pearson product–moment correlations found significant relationships between students' grades in the online class and their GPA, attendance at a class orientation session, the number of previous course withdrawals, ASSET reading scores, the number of previous online courses, age, and ACT English scores. Regression analysis found that two variables serve as the best predictors: attendance at an orientation session, and the student's grade point average.
Combination of Hyperammonaemia and Tachyarrhythmia in a Newborn with Carnitine-acylcarnitine Translocase Deficiency

Carnitine-acylcarnitine translocase (CACT) deficiency is one of the fatty acid oxidation defects that presents early in the newborn period. It is known to be associated with a high mortality with a number of the earlier reported cases presenting as sudden infant death syndrome. Like most inborn errors of metabolism, presentation of CACT deficiency is rather non specific. Typical biochemical profile is one of hypoketotic hypoglycaemia with hyperammonaemia. While hyperammonaemia is a common feature for other IEMs like urea cycle disorders and organic acidurias, cardiac arrhythmias especially ventricular tachyarrhythmia are less commonly seen in them compared with fatty acid oxidation defects. Furthermore, patients with CACT deficiency may present without hypoglycaemia. We hereby reported a 5 day old male infant who was diagnosed to have CACT deficiency at post mortem examination. He presented with respiratory distress, deteriorated very rapidly and succumbed within 48 hours of presentation. Though hypoglycaemia was absent at initial presentation, hyperammonaemia and tachyarrhythmias were observed during the course of his rapid deterioration. We believe a combination of neonatal hyperammonaemia together with tachyarrhythymias should raise a strong clinical suspicion towards fatty acid oxidation defects. In Hong Kong CACT deficiency should be considered in this clinical context as it is one of the more commonly seen fatty acid oxidation defects among the Southern Chinese population.