Miracle-dz/UniFAR-FTUs huggingface dataset:
Are stem cells the future of healthcare

AbstractStem cell technology holds a key, although arguably not an exclusive position, in the future of healthcare. Alongside two other candidates worthy of this mantle – personalized cancer medicine and vaccine development – all three healthcare innovations are explored primarily from a scientific and also an ethics perspective. This insightful and informative essay secured its 12-year old author a place on Newcastle Upon Tyne's city universities’ ‘Leading Edge’ science programme in January 2012. The programme forges links between local academics and enthusiastic youngsters aged 12–14 years, selected from 13 participating schools. The aim is to motivate and inspire children to consider careers in science. Supported by their science teacher Jonny Instone, Gosforth Central Middle School's team of six, including the author, worked with Dr Ben Horrocks from the University of Newcastle Upon Tyne's Chemical Nanosciences Laboratories in the School of Chemistry. Their four-month nanotechnology project focused on.
Phenotypes and Genotypes of Mitochondrial Disease- Findings from A National Mitochondrial Disease Cohort (P2.061)

Objective: To better understand the demographic distribution of mitochondrial disease, phenotypic and genotypic variability and progression associated with mitochondrial disease. Background: The phenotypic and genotypic heterogeneity in mitochondrial disease often poses a considerable diagnostic challenge to clinicians and scientists. To date, there are few effective treatments and no known cure for mitochondrial disorders hence supportive care with multi-disciplinary input remains a fundamental element in daily clinical practice. However, the lack of natural history makes prognostication, long-term management, genetic counselling and discussion of reproductive options extremely difficult. Methods: The MRC Mitochondrial Disease Patient Cohort Study (UK) was developed in 2009. Patients with biochemical and/or genetic evidence of mitochondrial disease are recruited from three principal mitochondrial disease centres (Newcastle, London and Oxford) with additional 9 secondary centres. Data collated both retrospectively and prospectively include clinical phenotype, family pedigree, molecular genetics, muscle biopsy findings, blood tests, neurophysiological evaluation, brain and cardiac imaging investigations and Newcastle Mitochondrial Disease Adult Scale (NMDAS) scores in a systematic fashion. NMDAS and its paediatric equivalence are used to examine individual disease burden and progression. Results: There are 1165 patients (85[percnt] are adults) registered on the cohort. Sixty-five percent of patients have primary mitochondrial DNA mutations, 23[percnt] have mutations in nuclear genes and 12[percnt] have biochemical evidence of mitochondrial disease but genetically undetermined. The common neurological features (based on NMDAS, n=452) are myopathy (64[percnt]), chronic progressive external ophthalmoplegia (40[percnt]), cerebellar ataxia (39[percnt]), cognitive impairment (33[percnt]), dysphagia (21[percnt]), epilepsy (19[percnt]) and stroke-like episode (9[percnt]). Other systemic involvements are gastrointestinal (44[percnt]), endocrine/diabetes (22[percnt]) and cardiac (20[percnt]). Conclusion: This national cohort offers a unique opportunity to deep phenotype a large group of mitochondrial disease patients, bridge the gap in our understanding of disease progression, develop clinical guideline on patient care and facilitate patient recruitment for any future trials. Disclosure: Dr. Ng has nothing to disclose. Dr. Gorman has nothing to disclose. Dr. Nesbitt has nothing to disclose. Dr. Pitceathly has nothing to disclose. Dr. Grady has nothing to disclose. Dr. Schaefer has nothing to disclose. Dr. Bright has nothing to disclose. Dr. Feeney has nothing to disclose. Dr. Rahman has nothing to disclose. Dr. Poulton has nothing to disclose. Dr. Taylor has nothing to disclose. Dr. Hanna has received personal compensation for activities with Bristol-Myers Squibb as an employee. Dr. Turnbull has nothing to disclose. Dr. McFarland has nothing to disclose.
Ruminal Acidosis in Small Ruminants and its Therapeutic management

Ruminal lactic acidosis often referred to as grain overload, develops as a result of animals consuming large quantities of carbohydrates resulting in large economic losses and mortality. A total of 10 sheep and 5 goats aged from 3 month to 5 year were presented with history of accidental ingestion of rice and acute bloat. Animal presented were recumbent, anorectic, not ruminating, depressed with severe diarrhoea and distension of abdomen. All animals were having respiratory distress due to acute bloat hence gas was relieved by inserting 16 gauze needle in left paralumbar region. The pH of ruminal fluid ranged from 3–5 which indicated ruminal acidosis in all the animals. Rumen fluid colour was milky grey, consistency was watery with foul odour. On microscopic examination number of protozoa was nil. After relieving gas, simethicone was given intrarumen along with intravenous administration of ringers lactate. Sodium bicarbonate was given intraruminal and other supportives was recommended. The animals recovered uneventfully.
Gatot Subroto

Indicator of coffee resistance to leaf rust attack (Hemileia vastatrix) is needed to select superior coffee plants resistant to biotic stress. This study aimed to determine the relationship between the content of secondary metabolites and the intensity of leaf rust attack, therefore, it becomes a reference in the selection of future coffee plants. The experimental design used was a completely randomized design (CRD) with five coffee clones, including Komasti Maragogik, Usda, Andong sari, and HDT (Hybrido de Timor) as treatment. Each treatment consisted of 3 replications, and each replication consisted of 2 sample plants. Observations were made by observing the intensity of the attack, and plant metabolites such as phenolic content, flavonoids content, and antioxidant activity observed when the leaves had been attacked by H. vastatrix . The correlation analysis between leaf rust attack intensity and the plant metabolites showed a relationship between each observation variable. Flavonoid content in certain conditions can be used as an indicator to get Arabica coffee plants that are resistant to the attack of leaf rust. Received: 25th December 2018; Revised: 16th May 2019; Accepted: 21st May 2019
Further Scaling of Isabelle Technology

Over 32 years, Isabelle has made a long way from a small experimental proof assistant to a versatile platform for proof document development. There has always been a challenge to keep up with the natural growth of applications, notably the Archive of Formal Proofs (AFP). Can we scale this technology further, towards really big libraries of formalized mathematics? Can the underlying Scala/JVM and Poly/ML platforms cope with the demands? Can we eventually do 10 times more and better? In this paper I will revisit these questions particularly from the perspective of: • Editing: Prover IDE infrastructure and front-ends, • Building: batch-mode tools and background services, • Browsing: HTML views and client-server applications.
General Face Analysis Framework

Face analysis systems have recently gained popularity due to the large number of potential applications across a wide range of industries. Various types of information can be extracted from an image of a face including: face location and size, location of characteristic facial landmark points, 3D head pose, facial expression and emotion, gaze direc­ tion and biometric information (i.e. age, gender and race). Most of these problems are solved using machine learning techniques based on large sets of training samples. Fur­ thermore, information from these different tasks is often complementary and can be used to enhance the accuracy of the algorithms. A systematic overview of current ap­ proaches to face analysis tasks is presented as an intro­ duction to this growing research field.
Uso off label do bevacizumabe no tratamento da degeneração macular relacionada à idade

Durante os ultimos anos, cresceu o uso dos medicamentos off label, definidos comoaqueles utilizados para indicacoes terapeuticas nao previstas no registro concedido pelosorgaos regulatorios. Um exemplo recente e o uso do Bevacizumabe no tratamento dadegeneracao macular relacionada a idade (DMRI), doenca responsavel pela perda davisao associada ao envelhecimento. Objetivo: Relatar o uso de Bevacizumabe comomedicamento off label na terapeutica da DMRI. Metodo: Trata-se de estudo de revisaoda literatura narrativa realizado em periodicos nacionais e internacionais, com osdescritores bevacizumabe, off label, degeneracao macular relacionada a idade efarmacoeconomia. Resultados: A pesquisa apurou a descricao do uso do Bevacizumabepara DMRI em protocolos clinicos e artigos cientificos, dentre os quais destacaram-se umestudo clinico envolvendo 1200 pacientes e um instrumento legal do governo brasileirorecomendando o uso do Bevacizumabe para o tratamento de DMRI. Conclusoes: O usoda droga estudada na forma de injecao intravitrea (IV) para combate a DMRI, apresentaseefetivo, com boa margem de seguranca, e mecanismo de acao compativel quandocomparado a outras drogas. Destaca-se tambem a avaliacao farmacoeconomica quetrouxe resultados positivos quanto ao uso do Bevacizumabe no tratamento da DMRI.
Visualizing World Bank indicators through Google Earth

The goal of the project is to develop a large visual data resource for Google Earth using major education, gender, and health datasets. With global data increasingly being made public by organizations such as the World Bank, global data modeling has been a significant development in information visualization and geographical information systems. While there is a considerable amount of publicly owned and open-source data sets available, there has been minimal development beyond proof-of-concept ideas. The current research project is to model five major domains of the World Bank's global datasets. The global datasets being modeled are education, women and gender issues, health care access, life expectancy and wellness, and access to the Internet and technology. Each dataset is comprised of between 5-15 sub-elements that are being modeled as well. A data translation key has been developed for data migration into Google Earth's KML format, and modeling is expected to be finished by April 2011. After the Google Earth models are complete, the resulting KML files will be made available for public use. It is hoped that a greater global awareness will develop by using the World Bank/Google Earth data. Additionally, data development will be easier once the data key is published.
UvA-DARE (Digital Academic Repository) Markov Chain Monte Carlo and Variational Inference: Bridging the Gap Salimans,

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An Effective Energy Management of Nodes in MANET based Swarm Intelligence with Feature Selection Methods

Now-a-days constraints of hardware and resource efficient routing are very important for construct at Mobile Adhoc Network. Previous works describe the ABC and WO based energy efficiency. The proposal paradigm intends to reach a particular quality requirement for MANET. A novel Swarm Intelligence and Feature selection methods are developed to new routing algorithm for managing high energy. The protocol grouped together based on their structure, energy, computational complexity and path establishment. To evaluated and compares MANET routing protocols for wireless sensor network. Swarm intelligent found that not only energy as well as has the performance in both routing and Quality of Packet delivering. To using Feature selection method is to find optimal route which from feasible route. This method is to improve the quality of MANET and find intrinsic properties of energy management. The new proposal Improved Swarm Intelligence Routing Algorithm (ISRA) to have standard simulation and performance metrics for comparing different protocol using NS2 based simulator and discover the efficiency.
INVESTIGATION INTO A LAYERED APPROACH TO ARCHITECTING SECURITY-INFORMED SAFETY CASES

The paper describes a layered approach to analysing safety and security in a structured way and creating a security-informed safety case. The approach is applied to a case study – a Security Gateway controlling data flow between two different security domains implemented with a separation kernel based operating system in an avionics environment. We discuss some findings from the case study, show how the approach identifies and ameliorates important interactions between safety and security and supports the development of complex assurance case structures.
Blood feast: Exploring the erythrocyte‐feeding behaviour of the myxozoan Sphaerospora molnari

As the most abundant cell population in the blood, erythrocytes represent an attractive source of nutrients and a protective niche to a number of pathogens. Previously, we observed the attachment of the myxozoan parasite Sphaerospora molnari to erythrocytes of its host, common carp (Cyprinus carpio), raising a number of questions about the nature of this interaction.
Can radiology reflect patient satisfaction after hallux valgus surgery?

OBJECTIVES This study aims to define the first web space length (FWSL) as a new radiologic parameter, which may reflect patients' subjective satisfaction and be associated with American Orthopedic Foot and Ankle Society (AOFAS) score as an objective parameter. PATIENTS AND METHODS One hundred and fourteen patients (11 males, 103 females; mean age 43.4±13.2 years; range, 18 to 70 years) who underwent distal osteotomy between April 2010 and January 2018 were retrospectively reviewed. Patients were radiographically evaluated with pre- and postoperative standing foot anteroposterior and lateral X-rays. Hallux valgus angles (HVAs), intermetatarsal angle (IMA), and FWSL were measured. AOFAS scores were used for clinical evaluation. Satisfaction scores were obtained using a visual analog scale at the final follow-up. RESULTS The relationship between postoperative AOFAS score changes and postoperative HVA changes was statistically significant (p=0.001, p<0.1). The relationship between postoperative AOFAS values and postoperative FWSL changes was statistically significant (p<0.001, p<0.1). No statistically significant relationship was detected between postoperative AOFAS values and IMA changes (p=0.101, p>0.05). The relationship between AOFAS scores and satisfaction scale was statistically significant (r=0.695; p<0.001, p<0.01). The relationship between the satisfaction scale and FWSL was statistically significant (p=0.005, p<0.01). CONCLUSION The FWSL has an influence on patient satisfaction. It is correlated both with AOFAS scores and satisfaction scale. It can be used as a measurable parameter to detect patient satisfaction.
ORGAN DONATION AND TRANSPLANTATION: WHAT DO THE UPCOMING MEDICAL DOCTORS THINK ABOUT?

A majority of Europeans are willing to donate their organs after death; however there are differences among countries in the European Union. In Romania willingness to donate is low in the general population (31% in 2009), therefore educational strategies are necessary. Health care professionals should be primary information providers for the public. For this reason, we investigated the attitude of medical students towards organ donation and transplantation. From a total of 247 interviewed students, 81.8% were positive about donating own organs, while 65.5% were in favor of donating an organ of a close person, with a significant difference between preclinical years of study and final year (60% vs. 72%). Female students are more inclined to discuss about the topic of transplantation and organ donation, while married students manifest higher hesitation when deciding to donate a close person’s organ. Communication and emotional approach are keys of educational strategies in changing people’s behavior with regard to donation after death.
Calcium Antagonists-Induced Lower Urinary Tract Symptoms

Lower urinary tract symptoms (LUTS) are a group of obstructive and irritative urinary symptoms. These include storage, voiding, and post-micturition symptoms. LUTS are prevalent and bothersome in the rapidly growing ageing Australian population and they are associated with a significant deterioration in patients‟ quality of life (QoL). There are a number of risk factors for LUTS. These include medical conditions such as diabetes, stroke, Parkinson‟s disease along with some surgical procedures involving the pelvis or spinal cord. Ageing is also associated with structural and physiologic changes of the lower urinary tract which may contribute to LUTS. LUTS are often inappropriately thought of as a male only problem because of the high prevalence of benign prostatic hypertrophy (BPH) in older men; however, the development of LUTS is not gender specific and women may develop LUTS following menopause or post-hysterectomy. %%%%A number of drugs have been found to affect the bladder and the micturition process including the commonly prescribed calcium antagonists (CAs). CAs were the ninth most frequently prescribed group of drugs in Australia in the year 2008, with more than seven million prescriptions dispensed during that year. Apart for their effects relaxing the detrusor smooth muscle hence impairing micturition, CAs can also increase the production of urine through their natriuretic effect and cause constipation through their muscle relaxation and anti-cholinergic activity, which can further exacerbate LUTS. The association between CA use and LUTS is not well investigated. The aim of this research was to investigate the association between CA use and LUTS in males and females. Further to assess the consequences of CA-associated LUTS on users‟ QoL and receipt of treatment for LUTS. %%%%During the Phase 1 of this research, a review was conducted for all reports submitted to the Adverse Drug Reaction Advisory Committee (ADRAC) of Australia up until January 2009. The review revealed 80 reported cases (females 45 [56.2%], males 34 [42.5%]). The mean age of the patients was 63.4±14.1 years (range 36-99 years). Amlodipine was the most frequently reported drug and lercanidipine was the least reported. Pollakiuria and other obstructive urinary symptoms were the most commonly reported symptoms. More than half of the patients (46; 57.5%) had complete resolution of their LUTS after medication discontinuation while 10 (12.5%) patients did not recover; an outcome was not reported for the remaining 24 (30%) patients. The review highlighted the importance of including females and younger patients in future studies. Further, it also suggested that LUTS associated with CA use is reversible in the majority of cases following medication discontinuation. %%%%A study was conducted, in Phase 2 of this research, to investigate the relationship between CA-use and LUTS amongst hospitalised medical patients at Royal Perth Hospital. The study also looked at the impact of CA-associated LUTS on patients‟ urological QoL. A demographic questionnaire was…
Jasmonate Signaling during Arabidopsis Stamen Maturation

Abstract The last stages of stamen development, collectively called stamen maturation, encompass pollen viability, filament elongation and anther dehiscence or opening. These processes are essential for male fertility in Arabidopsis and require the function of jasmonate signaling. There is a good understanding of jasmonate synthesis, perception and transcriptional outputs in Arabidopsis stamens. In addition, the spatiotemporal localization of jasmonate signaling components at the tissue and cellular levels has started to emerge in recent years. However, the ultimate cellular functions activated by jasmonate to promote stamen maturation remain unknown. The hormones auxin and gibberellin have been proposed to control the activation of jasmonate synthesis to promote stamen maturation, although we hypothesize that this action is rather indirect. In this review, we examine these different areas, attempt to clarify some confusing aspects found in the literature and raise testable hypothesis that may help to further understand how jasmonate controls male fertility in Arabidopsis.
Prognostic value of high stanniocalcin 2 expression in solid cancers

Abstract Background: Several studies have explored the prognostic value of stanniocalcin 2 (STC2) in various cancers, but obtained inconsistent results. Therefore, this meta-analysis was performed to determine the prognostic and clinicopathologic significance of STC2 in various cancers. Methods: Eligible studies were identified by searching the online databases PubMed, Embase, Web of Science, and the China National Knowledge Infrastructure up to March 2019. Hazard ratios (HRs) with 95% confidence intervals (CIs) and were calculated to clarify the correlation between STC2 expression and prognosis of different cancers. Odds ratios (ORs) with 95% CI were selected to appraise the correlation between STC2 with clinicopathologic characteristics of patients with cancer. Results: A total of 16 eligible studies with 4074 patients with cancer were included in our meta-analysis. The results showed that high STC2 expression can predict poor overall survival (OS) for cancer (HR = 1.48, 95% CI: 1.15–1.90, P = .002). Subgroup analysis found that high STC2 expression was associated with worse OS in Asian (HR = 1.85, 95% CI: 1.35–2.55), the reported directly from articles group (HR = 1.39, 95% CI: 1.05–1.84), survival curves group (HR = 1.93, 95% CI: 1.36–2.74), and gastric cancer (HR = 1.43, 95% CI: 1.04–1.95). Furthermore, high STC2 expression was significantly related to advanced T stage (OR = 1.83, 95% CI: 1.17–2.86, P = .008), lymph node metastasis (OR = 2.29, 95% CI: 1.51–3.45, P < .001), lymphatic invasion (OR = 2.15, 95% CI: 1.53–3.02, P < .001), venous invasion (OR = 1.97, 95% CI: 1.30–2.99, P = .001), and more advanced clinical stage (OR = 2.36, 95% CI: 1.74–3.19, P < .001) Conclusion: Elevated expression of STC2 suggested a poor prognosis in patients with cancer and may serve as a new tumor marker to monitor cancer development and progression.