Miracle-dz/UniFAR-FTUs huggingface dataset:
An effective coaxiality error measurement for twist drill based on line structured light sensor

 Abstract— Since the structure of twist drill is complex, it is hard and challenging for its coaxiality error measurement. In this paper, a novel mechanism, framework and method of coaxiality error measurement for twist drill is proposed. The mechanism includes encoder, PLC controller, line structured sensor and high precision turntable. First, profile point cloud data of the twist drill is collected through the line structured light sensor when the drill turns around in the controlling of PLC. Second, a GMM-based point cloud segmentation algorithm based on local depth features is investigated to extract blade back data. To improve the measurement accuracy, a statistical filter is designed to remove outliers during the target region extraction. Then, according to two characteristics of coaxiality error, an axis reconstruction method based on orthogonal synthesis of axisymmetric contour differences is presented, which is facilitated to pre-position the maximum deviation cross sections of the drill axis. Finally, the coaxiality error is measured through fitting the benchmark axis and the axis at the pre-positioned maximum deviation position. At the end, a large number of experiments are carried out, and it shows that our method is accuracy and robust.
Morbidity and Mortality of Red Foxes (Vulpes vulpes) and Gray Foxes (Urocyon cinereoargenteus) Admitted to the Wildlife Center of Virginia, 1993–2001

The medical records of 48 red foxes (Vulpes vulpes) and 35 gray foxes (Urocyon cinereoargenteus) examined at the Wildlife Center of Virginia (Waynesboro, Virginia, USA) from 1993 to 2001 were reviewed. The most common diagnosis in red foxes was orphaned (33%), followed by trauma (27%), undetermined diagnosis (23%), and sarcoptic mange (17%). Trauma (46%) was the most frequent cause of morbidity and mortality in gray foxes followed by orphaned (23%), undetermined (20%), toxoplasmosis (6%), presumptive canine distemper (3%), and rabies (3%). One gray fox had concurrent toxoplasmosis and presumptive canine distemper (3%). Similar diseases were detected in previous studies at a diagnostic laboratory; however in this study, trauma and orphaned animals were more common than infectious diseases. The lack of diagnostic information on some cases limited the usefulness of this study, and more emphasis should be placed on performing postmortem examinations of wildlife presented to wildlife rehabilitation centers.
A novel SU-8 electrothermal microgripper based on type synthesis of kinematic chain method

Microgrippers act as an important role in MEMS, it is necessary to explore new and systematic approach for microgripper design. A new systematic design procedure used for chevron electrothermal actuator driven microgrippers is developed. A novel microgripper is obtained by this procedure based on type synthesis of kinematic chain method. And a geometry optimization is also carried out. By a novel processing technology, the novel SU-8 microgripper with an actuator of three layer sandwich structure is fabricated. With only 423.1 mV, 108.5 mW and 77.8 °C temperature increase at the actuator, a 68.5 µm jaws gap change is obtain. And during the operation processes, the out-of plane displacement of the tip is always lower than 0.5 µm.
Three-Dimensional Lifting Model For Non-Homogeneous Loads

A 3-dimensional model and analysis methodology is suggested for treating lifting tasks when unbalanced loads are involved. The paper describes the biomechanical equations that are coupled with the worker’s posture geometry, to address a practical problem of non-symmetric lifting. The analysis has a dominant biomechanical modeling scope, as it contains a breakdown of the internal lifting forces resulting from posture and external loads acting on the body. The load model represents the acting forces due to unbalanced lifting, which is commonly found in industrial situations. The suggested model allows the user to simulate the influence of the practical load distribution, aiding safe design of a lifting job.
Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle.

The persistence of the broad-spectrum antiparasitic activity of endectocide compounds relies on their disposition kinetics and pattern of plasma/tissues exchange in the host. This study evaluates the comparative plasma disposition kinetics of ivermectin (IVM), moxidectin (MXD) and doramectin (DRM) in cattle treated with commercially available injectable formulations. Twelve (12) parasite-free male Hereford calves (180-210 kg) grazing on pasture were allocated into three groups of four animals each. Animals in each group received either IVM (Ivomec 1%, MSD AGVET, Rahway, NJ, USA), MXD (Cydectin 1%. American Cyanamid, Wayne, NJ, USA) or DRM (Dectomax 1%, Pfizer Inc., New York, NY, USA) by subcutaneous injection at a dose of 200 micrograms/kg. Jugular blood samples were collected from 1 h up to 80 days post-treatment, and plasma extracted, derivatized and analysed by high performance liquid chromatography (HPLC) using fluorescence detection. The parent molecules were detected in plasma between 1 h and either 70 (DRM) or 80 (IVM and MXD) days post-treatment. The absorption of MXD from the site of injection was significantly faster (absorption half-life (t1/2ab) = 1.32 h) than those of IVM (t1/2ab = 39.2 h) and DRM (t1/2ab = 56.4 h). MXD peak plasma concentration (Cmax) was reached significantly earlier (8.00 h) compared to those of IVM and DRM (4-6 days post-treatment). There were no differences on Cmax values: the area under the concentration-time curve (AUC) was higher for IVM (459 ng.d/mL) and DRM (627 ng.d/mL) compared to that of MXD (217 ng.d/mL). The mean plasma residence time was longer for MXD (14.6 d) compared to IVM (7.35 d) and DRM (9.09 d). Unidentified metabolites were detected in plasma: they accounted for 5.75% (DRM), 8.50% (IVM) and 13.8% (MXD) of the total amount of their respective parent drugs recovered in plasma. The comparative plasma disposition kinetics of IVM, MXD and DRM in cattle, characterized over 80 days post-treatment under standardized experimental conditions, is reported for the first time.
A Cross-Sectional Study of Set Shifting Impairments and Falling in Individuals with and without Parkinson’s Disease

INTRODUCTION. Individuals with Parkinson’s disease (PD) are at increased risk for falls, and exhibit deficits in executive function, including Set Shifting, which can be measured as the difference between parts B and A of the Trailmaking Test. METHODS. We conducted a cross-sectional study using baseline data of PD patients with and without freezing of gait (FOG) (n=69) and community-dwelling neurologically-normal older adults (NON-PD) (n=84) who had volunteered to participate in clinical rehabilitation research. Multivariate logistic regression analyses were performed to determine associations between Set Shifting, PD, and faller status, as determined by ≥1 self-reported falls in the previous 6 months, after adjusting for demographic and cognitive factors and clinical disease characteristics. RESULTS. Impaired Set Shifting was associated with previous falls after controlling for age, sex, overall cognitive function, PD, FOG, and PD disease duration (OR=1.29 [1.03-1.60]; P=0.02). In models controlling for age, sex, and overall cognitive function, PD was associated with increased fall prevalence among the study sample (OR=4.15 [95% CI 1.65-10.44], P<0.01) and FOG was associated with increased fall prevalence among the PD sample (OR=3.63 [1.22-10.80], P=0.02). Although the strongest associations between Set Shifting and falling were observed among PD without FOG (OR=2.11) compared to HOA (OR=1.14) and PD with FOG (OR=1.46) in a multivariate model that allowed for interaction between set shifting and PD status, there was insufficient evidence to reject the null hypothesis of no interaction. CONCLUSIONS. Set Shifting is associated with previous falls in non-demented older adults with and without PD. Highlights Individuals with PD are at increased risk for falls, although causes are unclear. Impaired Set Shifting was associated with falls in older adults with and without PD. Associations were strongest among those with PD but without freezing of gait.
Improving Stability of a DFIG-Based Wind Power System With Tuned Damping Controller

This paper focuses on the implementation of a damping controller for the doubly fed induction generator (DFIG) system. Coordinated tuning of the damping controller to enhance the damping of the oscillatory modes is presented using bacterial foraging technique. The effect of the tuned damping controller on converter ratings of the DFIG system is also investigated. The results of both eigenvalue analysis and the time-domain simulation studies are presented to elucidate the effectiveness of the tuned damping controller in the DFIG system. The improvement of the fault ride-through capability of the system is also demonstrated.
Understanding Prior Dropout in Psychotherapy

Little is known about clients who, although in need of a treatment and having the opportunity to take treatment, do not start it. To explore this topic, we conducted a retrospective study comparing 37 prior dropouts with 28 clients who underwent treatment (family therapy). Results showed that prior dropout clients presented symptoms for a longer period, attended previous family therapy and previous psychiatric urgency; while clients with previous psychiatric internment presented a strong tendency not to dropout. The findings suggest that previous experiences with specific mental health assistance influence the engagement in future treatments. Recommendations are made for the use of retrospective studies based on clinical records of clients, in order to detect predicting variables of prior dropout and avoid nonresponse problems at the time of design prevention strategies.
Association of tumorigenic and nontumorigenic (immunogenic) variants in a mouse t‐cell lymphoma with two distinct p53 mutations

An in vitro model system for xenogenization has been developed in which an immunogenic, nonmalignant phenotype was selected from a highly malignant T‐cell line (S49). We showed by single‐strand conformation polymorphism and DNA sequence analysis that specific point mutations in the p53 tumor suppressor gene correlated with a change from a tumorigenic to a nontumorigenic (immunogenic) phenotype. Specifically, we found that the highly malignant S49 cell line T‐60 contains an Arg→Gln substitution at residue 246 in exon 7 of p53. In contrast, nontumorigenic (immunogenic) variants (T‐25‐Adh and Rev‐1) exhibited a Gly→Ser substitution at residue 242 of p53. In two subsequent tumorigenic revertants derived from Rev‐1, we again found the Arg→Gln substitution at residue 246 that was found initially in the T‐60 cells. Thus, mutation at residue 246 of p53 was associated with a highly malignant phenotype, whereas a novel mutation at residue 242 of p53 appeared to be associated with a nonmalignant phenotype and may have actually protected the host through immunization. We conclude that mutation of residue 242 may represent a new class of permissive (nonmalignant) mutations in the mouse that are analogous to the Li‐Fraumeni mutation in humans. © 1993 Wiley‐Liss, Inc.
Baseline dependency of nicotine’s sensory gating actions: similarities and differences in low, medium and high P50 suppressors

Reduced suppression of the P50 auditory event-related potential in schizophrenia patients relative to normal controls is indicative of a sensory gating deficit and is one of the most robust findings reported for functional brain abnormalities in this disorder. However, there is considerable gating variability in patients and controls and there is little understanding as to how inter-individual differences moderate gating responses to drugs and nicotinic agonists in particular, which have shown potential to reverse gating deficits. In this study the effects of acutely administered nicotine (gum, 6 mg) on sensory gating in a paired (S1–S2) auditory stimulus paradigm were investigated in 57 healthy, non-smoking volunteers stratified as low (n = 19), medium (n = 19) and high (n = 19) P50 suppressors on the basis of three separate baseline derived gating indices, P50 ratios, P50 difference scores, and gating difference waveforms. Relative to placebo, nicotine consistently improved gating in low suppressors as stratified with all three gating indices, exerted no effects in medium suppressors and reduced gating in high suppressors. Analysis of individual stimulus (S1, S2) amplitudes showed distinctly different mechanisms of action underlying nicotine effects in individuals with low and high baseline suppression. The results parallel similar findings of baseline-dependency in the gating effects of several antipsychotic drugs in healthy volunteers and support the use of group segmentation as a translational model in novel cognitive drug development for schizophrenia.
Prolonged postictal encephalopathy

Eleven patients (6 males, 5 females; ages 7.5 to 40 years, mean 27.8) had prolonged postictal confusion lasting from 4 to 10 days. During that time, the EEG showed a typical encephalopathic pattern. Comprehensive evaluation ruled out the possibility of metabolic, toxic, drug-related, or ongoing nonconvulsive status epilepticus. We have designated this syndrome as prolonged postictal encephalopathy (PPIE). Nine of 11 patients were mildly to borderline mentally retarded. Ten had previous episodes of status epilepticus. Nine of 11 had minimal structural abnormalities (mainly diffuse cortical atrophy). Nine patients had multiple recurrent episodes of PPIE. All episodes occurred following a cluster of seizures: in 8 patients after a cluster of generalized tonic-clonic seizures, in 2 after complex partial seizures, and in 1 patient after a cluster of atypical absence seizures. This series suggests that vulnerability to develop PPIE exists in patients with diffuse structural abnormalities, mild to borderline mental retardation, a history of status epilepticus, and a tendency of seizures to cluster.
Lower frequency of NPM1 and FLT3‐ITD mutations in a South African adult de novo AML cohort

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hemopoietic progenitor cells diagnosed in individuals of any age, but with a median age of 67 years at presentation in adults. Assessment of the mutation status of nucleophosmin protein‐1 (NPM1) and FMS‐like tyrosine kinase 3 internal tandem duplication (FLT3‐ITD) is essential for the prognosis, and treatment of AML.
Effects of nutrition on timing of mineralization in teeth in a Peruvian sample by the Cameriere and Demirjian methods

Background: Few studies have been conducted among children to investigate the effects of malnutrition and race on the timing of tooth formation. Aim: The study investigated whether there is a significant association between nutritional status, gender, and the process of tooth mineralization. Subjects and methods: Orthopantomograms of 287 Peruvian schoolchildren, aged 9.5–16.5 years, were evaluated. For each individual, we considered the number of the seven right permanent mandibular teeth, with completely closed apical ends of roots (N0), sum of normalized open apices (S), and the Demirjian score (Ds). We also estimated individual age by the Cameriere and Demirjian methods, and assessed their accuracy. Results: For each age class, the distributions of N0, S and Ds in the two sub-populations of Peruvian children, undernourished and well nourished, were not statistically significant. The mean error (ME) in age estimation was 0.75 and 1.31 years for the Cameriere and Demirjian methods, respectively. Conclusions: Nutrition did not seem to affect the process of tooth growth. As regards the accuracy of age estimation, the Cameriere method yielded more accurate estimates than the Demirjian method.
An Important Proportion of Genital Samples Submitted for Chlamydia trachomatis Detection by PCR Contain Small Amounts of Cellular DNA as Measured by β-Globin Gene Amplification

ABSTRACT We assessed the quality of genital samples submitted forChlamydia trachomatis detection by PCR by a second PCR assay for the presence of human β-globin DNA. Endocervical and urethral samples were first tested by the COBAS AMPLICOR C. trachomatis assay (Roche Diagnostic Systems) with an internal control and were then amplified for the presence of β-globin DNA with primers PC04 and GH20. Samples that contained inhibitors were retested after dilution 1:10. A total of 407 genital samples (311 endocervical swabs from 311 women and 96 urethral swabs from 95 men and 1 woman) collected over a 1-month period were evaluated. The internal control could not be amplified, despite dilution, from 3 of 23 samples that were retested after dilution because of inhibition, leaving 404 samples that could be analyzed by PCR. Eleven samples tested positive forC. trachomatis. Thirty (7.4%) of the 404 samples were negative for β-globin. Twelve of the 23 undiluted samples that contained inhibitors tested positive for β-globin DNA. Amplification of β-globin DNA in samples submitted for C. trachomatisdetection by the COBAS AMPLICOR C. trachomatis assay demonstrated that an important proportion of the samples did not contain cellular DNA. Assessment of the quality of the samples for PCR analysis by β-globin amplification is feasible but cannot replace use of the internal control.
Effects of pomegranate seed oil on oxidant/antioxidant balance in heart and kidney homogenates and mitochondria of diabetic rats and high glucose-treated H9c2 cell line

Objective: Oxidative stress is a major cause of diabetes complications. The present study aimed to investigate the beneficial effects of Pomegranate Seed Oil (PSO) on diabetes-induced changes in oxidant/antioxidant balance of the kidney, heart and mitochondria from rats and H9c2 cell line. Materials and Methods: In these in vivo and in vitro studies, male rats were divided into four groups (twelve each): group 1 served as control, group 2-4 received a single dose of streptozotocin (60 mg/kg, i.p), groups 3 and 4 received PSO (0.36 and 0.72 mg/kg/daily, gavage), respectively. After three weeks, six rats of each group and one week later the remaining animals were anaesthetized and the hearts and kidneys were removed and homogenized. Mitochondrial fractions were separated and enzyme activities were measured in each sample. H9c2 cells were pretreated with high levels of glucose (35 mM), and then, incubated with PSO. Finally, cell viability test, reactive oxygen species production and lipid peroxidation were evaluated. Results: Significant reduction in enzymes activity (Superoxide dismutase, Glutathione S-transferase and Paraoxonase 1), compensatory elevation in Glutathione Reductase, Glutathione Peroxidase and Catalase activity followed by reduction after one week and significant elevation in Oxidative Stress Index (OSI) were observed in diabetic group. PSO treatment resulted in a significant increase in enzymes activity and decreased OSI values compared to diabetic group in both tissue and mitochondrial fractions. PSO remarkably decreased glucose-induced toxicity, ROS level and lipid peroxidation in H9c2 cells. Conclusion: Results suggested that PSO has a protective effect against diabetes-induced alterations in oxidant/antioxidant balance in tissues, mitochondrial and H9c2 cell line.
Antimicrobial Susceptibility Testing of Porcine Brachyspira (Serpulina) Species Isolates

ABSTRACT No standardized method for susceptibility testing of Brachyspira spp. is currently available. A broth dilution procedure was evaluated and used to test the activities of six antimicrobial agents for 108 isolates of Swedish porcine Brachyspira spp. representing biochemical groups I, II, and III. Group I corresponds to Brachyspira hyodysenteriae, group II corresponds to B. intermedia, and group III corresponds to B. murdochii and B. innocens. A panel was designed with the antimicrobial agents dried in tissue culture trays with wells that allowed a liquid volume of 0.5 ml in each and agitation of the broth when incubated on a shaker. The MICs were determined by using brain heart infusion broth with 10% fetal calf serum. For 10 isolates, the results obtained in broth were compared to the MICs obtained on two different types of agar. Different inoculum densities and incubation times were also compared. The concentrations at which 90% of the B. hyodysenteriae isolates (n = 72) were inhibited in the broth dilution test by tiamulin (0.25 μg/ml), tylosin (>256 μg/ml), erythromycin (>256 μg/ml), clindamycin (>4 μg/ml), virginiamycin (4 μg/ml), and carbadox (0.06 μg/ml) were determined. The MICs tended to be lower in broth than on agar. Differences in inoculum densities and incubation times had little influence on the MICs. The evaluated broth dilution test was simple to perform, the end points were easily read, and the results were reproducible and reliable. No isolates with decreased susceptibility to tiamulin were found among the Swedish isolates tested.
Utility of a rapid polymerase chain reaction panel for the detection of molecular changes in B-cell lymphoma.

OBJECTIVE To evaluate the utility of a polymerase chain reaction (PCR)-based, B-cell-related molecular panel in the diagnostic workup of hematologic specimens. DESIGN, SETTING, AND PATIENTS A PCR panel was applied to 89 specimens from 87 patients, including 55 cases (57 specimens) of known monoclonal B-cell lymphoma, 10 cases of Hodgkin's disease, 2 cases of T-cell lymphoma, and 20 specimens of polyclonal reactive lymphoid tissues. The panel comprised a seminested PCR procedure for immunoglobulin heavy-chain (IgH) gene rearrangement and unnested PCR detection of t(14;18) and t(11;14). RESULTS Immunoglobulin heavy-chain was detected in 63%, evidence of t(14;18) in 35%, and evidence of t(11;14) in 3.5% of all the B-cell lymphoma cases. Seventy-seven percent of all cases demonstrated IgH- and/or bcl-2-associated translocations using these primers. The IgH primers alone detected clonality in 82% (28/34) of the nonfollicular lymphomas and 35% (8/23) of the follicular lymphomas, with no false positives in the non-B-cell lymphoma specimens. The addition of two primer sets for the detection of both IgH and bcl-2/JH significantly improved the detection of molecular abnormalities in the follicular lymphoma group from 35% to 70% (16/23). However, no change was noted in the overall detection rate for the nonfollicular lymphoma group. Adding primers for bcl-1/JH did not change the overall detection rate for either group. CONCLUSIONS Seminested PCR for IgH detected monoclonality in the majority of the nonfollicular lymphomas and is a valuable diagnostic tool in this group. The combination of different primer sets for the detection of IgH gene rearrangement and bcl-2/JH is most desirable for follicular lymphomas.
Yersinia enterocolitica biotype 3B serotype 03 phage type II infection in pigs.

Pigs were examined on one farm for carrier status of yersiniae during a 6-year period. The most predominant strain of pathogenic Yersinia enterocolitica isolated from pig feces was the new biotype 3B serotype 03 phage type II. It was suggested that the disappearance of biotype 4 serotype 03 and biotype 2 serotype 05, 27 strains from this farm may be dependent on the protection against the intra-intestinal re-settlement by biotype 3B setotype 03.