Miracle-dz/UniFAR-FTUs huggingface dataset:
Merhamet Korkusu: Tanımı, Nedenleri ve Önlenmesi

Bireyin, ruh sagligin icin yapilan tum islemler, olumlu duygu ve dusunceleri arttirmaya ve olumsuz duygu ve dusunceleri da azaltmaya yoneliktir. Fakat bazi bireyler, olumlu duygu ve dusuncelerden kacarlar, onlardan korkarlar. Merhamet duygusu, kimi insanlarin farkli nedenlerden dolayi, korktugu, cekindigi, kendinden uzaklastirmaya calistigi duygulardan biri olabilmektedir. Merhamet korkusu hem merhamet yoksunlugundan hem de merhamet duygusunun varligindan korkmaktan kaynaklanan bir durumdur. Bu korku hem bireyin sagligini olumsuz etkilemekte hem de toplumsal iliskilerin bozulmasina neden olabilmektedir. Ayrica merhamet korkusu, depresyon, stres, empati, aleksitimi, yemek bozuklugu, mutluluk korkusu, post travmatik stres bozuklugu, kaygi ve panik atak bozuklugu gibi saglik sorunlariyla iliskilidir. Bu sorunlarla ilgili verilecek herhangi bir tedavinin basarili olabilmesi icin merhamet korkusunun tanimlanabilmesiyle yakin baglara sahiptir. Merhamet korkusunun kokenin de bazen cocukluk travmalari bazen de cocuklukta anne babayla kurulamayan sicak iliski yoklugu onemli bir neden olarak gorulmektedir. Bu makalede merhamet korkusu kavraminin taniminin yapilmasi, iliskili oldugu kavramlarin aciklanmasi, konuyla ilgili olcme araclarinin tanitilmasi ve bu yolla konu hakkinda yardim farkindaliginin arttirilmasi amaclanmistir. Bu amac dogrultusunda ulasilabilir guncel kaynaklar incelenmis ve gerekli degerlendirmelerde bulunulmustur.
Enhancing the Therapeutic Effects of Ethyl Pyruvate on Gastric Cancer through Knockdown of YAP1 Expression

Yes-associated protein (YAP) plays a critical role in tumor formation and malignancy of many cancers and has been shown to be the important therapeutic target. Ethyl pyruvate (EP), a stable lipophilic pyruvate derivative, is a potent inhibitor of high mobility group box-B1 (HMGB1) release and exerts significant anti-inflammatory activities. Previously, we reported the high expression of YAP1 and the antitumor effects of EP in gastric cancer (GC). However, whether small hairpin RNA (shRNA)-mediated knockdown of YAP1 expression enhances the antitumor effects of EP on GC is elusive. After GC SGC-7901 cells infected with lentivirus-mediated YAP1 shRNA vector were treated with 20mmol/L EP, the expression levels of HMGB1, receptor for advanced glycation endproducts (RAGE) and Protein kinase B (AKT) were identified by Real-time PCR and Western blot assays. Cell proliferative activities and independent growth were examined by MTT and colony formation assays, and their migration and metastasis were evaluated by wound-healing and Transwell assays. Cell apoptosis and cycle distribution were assessed by flow cytometry. As a result, EP coupled with YAP1 shRNA significantly decreased the expression levels of HMGB1, RAGE and AKT, inhibited the proliferative activities and migration and metastasis capabilities, and induced apoptosis and cycle arrest in GC cells compared with the single EP treatment. Taken together, knockdown of YAP1 enhances the inhibitory effects of EPon GC cells through inhibition of the HMGB1-RAGE and AKT pathways, and this may provide an attractive strategy for the treatment of GC.
INFLUENCE OF NON SURGICAL THERAPY ON SERUM ALBUMIN AND WBC COUNT IN DIABETIC AND NON DIABETICS WITH CHRONIC PERIODONTITIS

BACKGROUND: Periodontal disease is a complex, multifactorial, chronic inflammatory disease that involves destruction of Periodontium. Many systemic diseases have been implicated as risk factors or risk indicators in periodontal disease. Clinical research over the past decades has led to an improved understanding and appreciation of periodontal pathogens. It has been indicated that there might be a difference between serum Albumin levels and WBC count among Diabetic and non-Diabetic patients with chronic periodontitis. AIM: The aim of my study is to evaluate levels of serum Albumin and WBC [WHITE BLOOD CELLS] count in Diabetic and non-Diabetic patients with chronic periodontitis before and after phase I therapy. Materials and methods : 20 patients were divided in to two groups i.e., Group A [Diabetic], Group B [non Diabetic]. Clinical parameters like Gingival index [GI], Plaque index [PI], Probing depth [PD], Clinical attachment level [CAL] were recorded at baseline. Furthermore Biochemical parameters like serum Albumin, WBC counts were assessed at baseline and at 1 month after nonsurgical periodontal therapy. Results : The present study showed significant gain in serum Albumin and reduced values of WBC count in both groups with more gain in serum Albumin levels & decrease in WBC count more pronouncedly in Group B. Conclusion: Within the limitations of the study there is a significant correlation of serum Albumin and WBC levels. An elevated WBC count, along with a decreased value of serum Albumin has been observed before Scaling and root planning [SRP] . However after SRP decreased values of WBC, along with elevated values of serum Albumin has been observed there by establishing a correlation between periodontitis WBC and serum Albumin levels. Keywords: Periodontitis, serum Albumin, WBC, Diabetic, non-Diabetic.
A feasibility study into setting up a unique café in Cardiff, which will provide a different but cosy café experience.

iii Acknowledgements.iv Chapter 1: Introduction . 11 1.0. Introduction . 12 1.1. Overview of Enterprise Project . 12 1.2. Background of business . 12 1.3. Background of the café industry . 13 1.4. Main Aim: . 13 1.5. Objectives of Enterprise: . 14 1.6. Project Structure . 15 1.7. Summary . 15 Chapter 2: Literature Review . 16 2.0. Literature review . 17 2.
GRAPHICAL PASSWORD AUTHENTICATION - SURVEY

The most common computer authentication approach is to use alphanumerical usernames and passwords. This method has been proven to have vast drawbacks. For example, users tend to choose passwords that can be easily guessed. On the other hand, if a password is difcult to guess, then it is frequently difcult to remember. To address this problem, some researchers have developed authentication strategies that use images as passwords. In this paper, we conduct a complete survey of the current graphical password techniques. We classify these strategies into two categories: recognition-based and recall-based approaches. We discuss the strengths and barriers of each technique and point out the future research instructions in this area. We also try to answer two necessary questions: “Are graphical passwords as secure as text-based passwords? ”; “What are the important design and implementation issues for graphical passwords? ” This survey will be useful for data protection researchers and practitioners who are involved in nding an choice to text-based authentication methods.
Temporal networks: a review and opportunities for infrastructure simulation

ABSTRACT Complex network theory (CNT) has been providing the platform to simulate, analyze, and visualize different complex interdependent networks. Despite the successes of simulating and analyzing infrastructure networks based on their static topological characteristics using CNT, there remain some challenges pertaining to considering the temporal variation within such networks. This is an important aspect, especially that most infrastructure (e.g., transportation and power) networks are dynamic (i.e., evolve over time) and vary not only spatially but also temporally. In this respect, the current study focuses on first presenting a review of temporal network topological characteristics and modeling approaches. The different graphical representation techniques of temporal networks are then summarized and compared to their static counterparts. Finally, the study highlights the fact that considering the time dimension in simulating complex networks is a relatively new research field that presents new research frontiers for breakthrough opportunities in simulating complex interdependent infrastructure networks.
Immunotherapy of a squamous cell carcinoma in the perianal region using autologous dendritic cells in a horse

Summary A 23-year-old Trakehner mare was referred to the Department of Large Animal Medicine with an ulcerative cleft tumour dorsal of the anus and in poor body condition. An infiltrative growing squamous cell carcinoma (SCC) was diagnosed. Surgical treatment was not an option because of the tumour localisation and topical chemotherapy caused severe side effects (coprostasis), therefore an immunological therapeutic approach involving autologous monocyte-derived dendritic cells (DC) presenting tumour antigen on their surface was chosen. Dendritic cells were administered to the patient three times at intervals of four weeks to induce an immune response against the SCC. The tumour regressed in size, the ulcerated surface healed, body condition improved and coprostasis subsided. Six and a half months later small papillomatous neoplasms at the tumour scar led to a fourth treatment. During follow-up, those recurrences remained indifferent; the mare showed physiological behaviour and returned to leisure riding. This case report describes the effectiveness of so far infrequently described immunotherapy with DC in horses.
Should adults with a first episode of VTE undergo thrombophilia testing to prevent recurrent VTE?

Although the risk of recurrent venous thromboembolism (VTE) is slightly higher in patients heterozygous for the factor V Leiden mutation or for the prothrombin G20210A mutation compared with patients without these mutations, testing for these mutations is not associated with a change in the VTE recurrence rate over not testing (SOR: B, meta-analysis of cohort studies and single case-control study). Copyright © 2019 by Family Physicians Inquiries Network, Inc. DOI 10.1097/EBP.0000000000000513
The ergogenic effects of Eurycoma longifolia Jack: A pilot study.

Eurycoma longifolia Jack (ELJ), which contains quassinoids such as eurycomalacton, eurycomanon, and eurycomanol, has been reported to have aphrodisiac properties and to increase testosterone levels in men. Previous studies have established that the testosterone supplementation increases fat free mass, muscle strength, and muscle mass, which are important for physical function and athletic performance. Thus, the objective of this study was to investigate the effect of the increase in testosterone levels, obtained by administration of ELJ, on body composition and muscle strength and size in men.
Pomalidomide (POM) with or without low-dose dexamethasone (LoDEX) in patients (Pts) with relapsed and refractory multiple myeloma (RRMM): MM-002 phase II age subgroup analysis.

8532 Background: POM demonstrated clinical efficacy and favorable tolerability in RRMM pts previously treated with lenalidomide (LEN) and bortezomib (BORT), in the randomized, multicenter, open label MM-002 phase II trial. This analysis evaluated whether the efficacy and tolerability of POM+LoDEX treatment is consistent across age subgroups. Methods: Pts with RRMM who had received ≥ 2 prior therapies, including LEN and BORT, and were refractory to their last regimen were randomized to either POM+LoDEX (POM 4 mg/day, days 1–21 of a 28-day cycle; LoDEX 40 mg/week) or POM alone. End points included progression-free survival (PFS), response rate (based on EBMT criteria), response duration, and safety. A post-hoc analysis based on age (≤ 65 vs. > 65 yrs) was conducted. Results: A total of 221 pts with a mean age of 64 yrs (range 34–88) were randomized to POM+LoDEX (n = 113) or POM (n = 108). The efficacy outcomes and the most common treatment emergent grade 3/4 adverse events (AEs) for the age subgroups accord.
BIOREMEDIATION OF HEXAVALENT CHROMIUM WIDELY DISCHARGED IN LEATHER TANNING EFFLUENTS

The hexavalent chromium salts are widely used in many industries worldwide including leather tanning industry. The residues of these salts are discharged into the environment causing serious health hazardous to human, animals and plants. The chemical remediation of the Cr VI residues is costly and adds more pollutants to the environment. Therefore, the bioremediation of toxic hexavalent chromium residues is the aim of this study. For this purpose, the soil and wastewater samples from the heavily contaminated sites near tanneries were used for the isolation of Cr VI resistant bacteria. A total of 33 bacterial isolates was obtained from samples grown on LB medium amended with 50 mgL-1 potassium di chromate (Cr VI). These isolates were screened for their growth in the medium amended with Cr VI concentrations ranging between 100 and 200 mgL-1. Seven isolates showed tolerance to the highest concentration. These isolates were subjected to analysis of 16S rDNA genes followed by RFLP of the PCR product. The most promising isolate (No.3) that withstood the highest Cr VI concentration was further subjected to 16S rDNA gene nucleotide sequence. This isolate turned to be Microbacterim spp. with 98% similarity to the standard strain in the gene bank. The sequence was deposited in NCBI data bank under accession number mk878392. The efficiency of this indigenous strain of bacteria in removal of Cr VI from aquas solution showed that it was capable to remove 30% of Cr VI within first 20 hours then exponential increase took place after additional 20 hours. The total removal of Cr VI reached 97.2% after 96 hours of incubation. The immobilization of the strain on either alginate or chitosan accelerated the removal of Cr VI that reached 90% removal in 18 hours. This strain seems very promising as potential bioremediation agent for hexavalent chromium residues. The efficiency of this indigenous strain of bacteria in removal of Cr VI from aquas solution showed that this strain was capable to remove 30% of Cr VI in the first 20 hours then exponential increase took place after additional 20 hours. The total removal of Cr VI reached 97.2% after 96 hours of incubation. The immobilization of the same strain on either alginate or chitosan accelerated the removal of Cr VI that reached 90% removal in 18 hours. This strain looks very promising to develop as potential bioremediation agent for hexavalent chromium residues.
Asymmetric Effects of the Fiscal Balance on Monetary Variables: Evidence from Emerging Economies

This paper investigates the nonlinear impacts of fiscal balances on interest rates, exchange rates and inflation in large emerging economies. The paper applies asymmetric cointegration modelling in a nonlinear autoregression distributed lag framework to discriminate the effects of negative and positive changes in the fiscal balance on monetary variables in BRICs. This approach is advantageous to the analysis of dynamic asymmetric relationships in both the long and short run regardless of whether variables are a mix of I(0) and I(1). A distinctive feature of this study is that the main result indicates that monetary variables react differently to negative and positive changes in fiscal balances over the long run for Brazil and India, but not for the others. Since interest rates and inflation are more sensitive to worsening fiscal position, fiscal consolidation is an essential criterion for the effectiveness of monetary policy in the economies characterised with large fiscal imbalance and debt stocks, such as Brazil and India. The implementation of expansionary fiscal policy should be reconsidered carefully in economies with a better fiscal performance like China and Russia, since the persistently rising budget deficits eventually countered the effectiveness of monetary policy by keeping market interest rates and inflation at high levels. This paper provides evidence in favour of the dominant role of fiscal policy to stabilise monetary variables in large emerging economies. We also highlight the importance of long-term fiscal sustainability to improve the monetary policy effectiveness.
Coverage Decision-Making for Orthopedics Interventions in the Health Transformation Program in Iran: A Multiple Criteria Decision Analysis (MCDA)

Introduction: All governments, regardless of available resources, should move to establish a balance between the conflict of resource scarcity of health system and health care services required. This study applied a multi criteria decision analysis (MCDA) approach to contribute to priority-setting and the coverage decision-making on including uninsured orthopedics interventions in the healthcare transformation plan’s subsidized in Iran during year 2015. Methods: This study was conducted in four phases: a comprehensive review of studies related to the methods and criteria for prioritizing health services, identifying prioritization criteria, scoring and finalizing them, weighting of the criteria identified, and planning for a prioritized uninsured coverage for orthopedics intervention. Results: After screening the retrieved titles via PRISMA, from 350 papers, 12 studies were included. The main criteria used for the priority step in the health sector were as follows: safety, efficacy, need, existence of alternative procedures, life expectancy impact, cost, cost-effectiveness, catastrophic health expenditure, impact on the budget, acceptance of social/economic and equity in access. According to the viewpoint of the experts, the safety criteria had maximum weight (0.4) and equity in access had the least weight (0.03). Finally, ten uninsured orthopedics services were prioritized with a score of 9.01 to 5.01. Conclusions: This practical and real-life project significantly contributed to rational, apparent, and unbiased priority-setting practice by using the MCDA methodology. Prioritizing and weighting the criteria in this study indicated that the Iranian policymakers should pay more attention to clinical aspects and benefits of the service than financial issues. This could indicate that there are social perspective and health as the public right in the country.
Detecting regional dominant movement patterns in trajectory data with a convolutional neural network

ABSTRACT Detecting movement patterns with complicated spatial or temporal characteristics is a challenge. The past decade has witnessed the success of deep learning in processing image, voice and text data. However, its application in movement pattern detection is not fully exploited. To address the research gap, this paper develops a deep learning approach to detect regional dominant movement patterns (RDMP) in trajectory data. Specifically, a novel feature descriptor called directional flow image (DFI) is firstly proposed to store the local directional movement information in trajectory data. A DFI classification model called TRNet is designed based on convolutional neural network. The model is then trained with a synthetic trajectory dataset covering 11 classes of commonly encountered movement patterns in reality. Finally, a sliding window detector is built to detect RDMP at multiple scales and a clustering-based merging method is proposed to prune the redundant detection results. Training of TRNet on the synthetic dataset achieves considerably high accuracy. Experiments on a real-world taxi trajectory dataset further demonstrate the effectiveness and efficiency of the proposed approach in discovering complex movement patterns in trajectory data.
Runtime analysis of Android apps based on their behaviour

In the modern world, Smartphones are everywhere and Android is the most used operating system. To protect these devices against malicious actions, the behaviour of Android apps needs to be studied. Current tooling does not provide complete insight into the behaviour of an Android app. A tool was built to observe what goes on inside an Android app. The tool can hook all functions and change the outcome of a function call. It is possible to log all method calls to observe when a method is called, with their arguments and return values. Every call the app makes inside the JVM can be shown and a complete picture of the application can be obtained. During this process the app stays responsive and will not slow down significantly. The information provided can be used for building a call graph, finding vulnerabilities or checking for app detection mechanisms.
Novel treatments for asthma: Corticosteroids and other anti- inflammatory agents.

Asthma management is a challenge due to the prevalence of disease in the world. Based on the immunological and inflammatory mechanisms of asthma, corticosteroids and anti-inflammatory participate greatly in the treatment plan. Due to different reasons, there is still an unmet need to develop new agents in this field. A lot of compounds with anti-inflammatory effect are investigated in both pre-clinical and clinical studies.
Tidig viktuppgång vid anorexia nervosa ger god prognos : Intensiv familjebaserad behandling ger bäst resultat

Vid anorexia nervosa orsakar svalten de allvarligaste symtomen, och risken for ett langdraget forlopp okar ju langre patienten ar i svalt. Avgorande for behandlingsresultatet ar att hava svalten sn .
Characteristics of Hospital Stays Involving Malnutrition, 2013

Undernutrition is a form of malnutrition characterized by a lack of adequate calories, protein, or other nutrients needed for tissue maintenance and repair.1 Malnutrition (undernutrition) occurs among approximately 3 percent of adult hospital inpatient stays in the United States and is associated with increased morbidity, mortality, and health care costs.2 Adult hospitalizations with a diagnosis of malnutrition have a longer length of stay, higher costs, more comorbidities, and 5 times the likelihood of death, compared with other adult hospital stays.3
Molecular structure, DFT studies, Hirshfeld surface analysis, energy frameworks, and molecular docking studies of novel (E)-1-(4-chlorophenyl)-5-methyl-N′-((3-methyl-5-phenoxy-1-phenyl-1H-pyrazol-4-yl) methylene)-1H-1, 2, 3-triazole-4-carbohydrazide

Abstract The synthesis of the compound and its crystal structure having a monoclinic crystal system has been reported earlier. Optimized bond lengths and angles are showing good agreements with experimental data using DFT/B3LYP method. Energy of highest occupied molecular orbital and lowest unoccupied molecular orbital has been predicted to analyze the stabilities of compound. Crystal explorer 17.5 helps to visualize intermolecular interactions and its contributions to each interaction within molecule. The preeminence of dispersion energy component over the other components was established by interaction energy calculations and lattice energy framework analysis using same software. The molecular docking study was performed for molecule using AutoDock software.