Miracle-dz/UniFAR-FTUs huggingface dataset:
Executive Functions in Patients with Familial versus Sporadic Schizophrenia and Their Parents

Background: The aim of this study was to investigate the executive functions in patients with sporadic schizophrenia (SS) and familial schizophrenia (FS), and the executive functions in their parents. Methods: The study included 30 patients with FS and their 37 parents with a positive family history of schizophrenia; 30 patients with SS and their 44 parents; 30 controls matched with the patients for gender, age and education, and 40 controls matched with the parents for gender, age and education (211 subjects in total). All the subjects were interviewed with the Structured Clinical Interview for DSM-IV-Axis I (SCID-I). The executive functions were assessed using the Verbal Fluency Test (VFT), the Trail Making Test (TMT), the Wisconsin Card Sorting Test (WCST) and the Stroop Test. Results: Patients with FS and their parents, and patients with SS performed significantly worse than their controls on the VFT, TMT, WCST and the Stroop test. There were no statistically significant differences between parents of patients with SS and their controls on any of the tests except for the Stroop color score. FS parents performed significantly worse than SS parents on all tests. FS patients performed significantly worse than SS patients on the VFT, TMT, Stroop test. Conclusion: Previous studies that investigated the cognitive functions of relatives of patients with schizophrenia brought out inconsistent results. The present study investigated relatives with and without a family history of schizophrenia separately and found that executive functions were impaired only in parents with a positive family history of schizophrenia. These findings suggest that impairment in executive functions may represent a genetic endophenotype for schizophrenia.
Expression of feline type‐C virus in normal and tumor tissues of the domestic cat

Tumor and normal tissues from domestic cats were examined for FeLV and RD‐114 specific nucleic acids and proteins. Virus‐positive tissues showed a 100‐ to 200‐fold higher level of FeLV and a 200‐ to 400‐fold higher level of FeLV p30 than virus‐negative tumors and normal cat tissues. In contrast, the levels of RD‐114 viral RNA and p30 antigen were comparable in the majority of tumorous and normal tissues examined. When the DNA of these tissues was examined for FeLV‐related sequences, the virus‐positive tumors were found to contain extra copies of FeLV DNA. Virus‐negative tumors contained DNA sequences homologous with FeLV but the copy number of these sequences could not be distinguished from normal tissues. The results indicate that in certain FeLV‐induced type‐C lymphoproliferative diseases, extra type‐C sequences not present in normal tissues can be identified.
A Construction of Knowledge Base for Personality Estimation based on Submitted Text Data in Twitter or Blogs

The personality that is estimated based on documents of blogs or tweets in Twitter can not agree in the senderâs real personality. It is important that we recognize the difference between these estimated and real personalities. This paper constructs a knowledge-base for extracting the senderâs virtual personality in customer-generated media. We focus on senderâs emotions that are included in senderâs posts for automatic personality estimation. We examined the correlation between the ratio of each emotion term (anger, sadness, fear, disappointment, regret, guilt, shame, pleasure, and ease) in all sentences of each participant and the values of NEO-FFI (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness to Experience) based on the experiment that human subjects who stayed in each senderâs character answered to NEO-FFI.As an evaluation result, we find out that the senderâs virtual personality is potentially-correlated with emotions in senderâs posts.
Elliptic systems with boundary blow-up: existence, uniqueness and applications to removability of singularities

In this paper we consider the elliptic system $\Delta u = u^p -v^q$, $\Delta v= -u^r +v^s$ in $\Omega$, where the exponents verify $p,s>1$, $q,r>0$ and $ps>qr$, and $\Omega$ is a smooth bounded domain of $R^N$. First, we show existence and uniqueness of boundary blow-up solutions, that is, solutions $(u,v)$ verifying $u=v=+\infty$ on $\partial \Omega$. Then, we use them to analyze the removability of singularities of positive solutions of the system in the particular case $qr\leq 1$, where comparison is available.
The State of the Art in Adaptive Information Agents

With the exponential growth of the Internet, information seekers are faced with the so-called problem of information overload. Adaptive Information Agents have been developed to alleviate this problem. The Main issues in the development of these agents are document representation, learning, and classification. Various paradigms have been explored for the development of adaptive information agents, and the performance of these agents differs in terms of computational efficiency, classification effectiveness, learning autonomy, exploration capability, and explanatory power. To develop a basic under-standing of the pros and cons of these paradigms, some representative information agents are examined. Such a review also serves to identify a general for the development of the next generation adaptive information agents.
EARNING A SCALE AND ROTATION INVARIANT INTEREST OPERATOR FROM HUMAN EYE FIXATIONS Bachelorproject

When humans look at an image they actively scan it, the eyes jump from one fixation point to another. These fixations represent the saliency of those points in the image. In previous studies Kienzle et al. (2006,2007) trained a Support Vector Machine (SVM) with these salient locations to calculate the saliency for new images without the use of biologically motivated methods. This model however does not take rotation and scale invariance into account. We developed methods that introduce rotation and scale invariance to Kienzle et al.'s model. The results of these models show that adding rotation invariance to the model increases it's performance, while adding scale invariance to the model does not improve the performance. Furthermore we developed a new way of selecting negative examples that are used to train the SVM, this method showed improvements in all models.
Transporters on Demand

ABC transporter trafficking in rat liver induced by cAMP or taurocholate and [35S]methionine metabolic labeling followed by subcellular fractionation were used to identify and characterize intrahepatic pools of ABC transporters. ABC transporter trafficking induced by cAMP or taurocholate is a physiologic response to a temporal demand for increased bile secretion. Administration of cAMP or taurocholate to rats increased amounts of SPGP, MDR1, and MDR2 in the bile canalicular membrane by 3-fold; these effects abated after 6 h and were insensitive to prior treatment of rats with cycloheximide. Half-lives of ABC transporters were 5 days, which suggests cycling of ABC transporters between canalicular membrane and intrahepatic sites before degradation. In vivo [35S]methionine labeling of rats followed by immunoprecipitation of (sister of P-glycoprotein) (SPGP) from subcellular liver fractions revealed a steady state distribution after 20 h of SPGP between canalicular membrane and a combined endosomal fraction. After mobilization of transporters from intrahepatic sites with cAMP or taurocholate, a significant increase in the amount of ABC transporters in canalicular membrane vesicles was observed, whereas the decrease in the combined endosomal fraction remained below detection limits in Western blots. This observation is in accordance with relatively large intracellular ABC transporter pools compared with the amount present in the bile canalicular membrane. Furthermore, trafficking of newly synthesized SPGP through intrahepatic sites was accelerated by additional administration of cAMP but not by taurocholate, indicating two distinct intrahepatic pools. Our data indicate that ABC transporters cycle between the bile canaliculus and at least two large intrahepatic ABC transporter pools, one of which is mobilized to the canalicular membrane by cAMP and the other, by taurocholate. In parallel to regulation of other membrane transporters, we propose that the “cAMP-pool” in hepatocytes corresponds to a recycling endosome, whereas recruitment from the “taurocholate-pool” involves a hepatocyte-specific mechanism.
Hydrology and nutrient effects on food-web structure in ten lake superior coastal wetlands

We examined the effects of hydrology and nutrients on the food webs of ten coastal wetlands on Lake Superior, using published stable isotope food web data for three wetlands and original data from seven additional systems in order to span regional hydrologic and nutrient enrichment gradients. We used a dual-source isotope mixing model to estimate the proportion of carbon in fish that originated from planktonic versus periphytic invertebrates, and we related carbon source to 1) nutrient enrichment, 2) hydraulic residence time, and 3) an index of nutrient loading that incorporates residence time and nutrient concentrations. There was no relationship between nutrient enrichment and the proportion of planktonic versus periphytic C in fish. Proportion of planktonic C in fish increased significantly with hydraulic residence time (F = 5.68, R2 = 0.42, p = 0.044). Riverine wetlands generally had lowest proportions of planktonic C in fish, dendritic wetlands were intermediate, and lagoon wetlands had highest proportions. A regression between the loading index and planktonic C in fish was an improvement over the residence time regression (F = 11.7, R2 = 0.59, p = 0.009). We conclude that coastal wetland food webs are strongly affected by hydrology and further by nutrient enrichment. This work has implications for the development of food web-based ecological indicators of nutrient enrichment and the use of hydrology as a classification factor in the prediction of nutrient effects on food webs.
Role of dendritic cells in the immune response against allografts

Graft-derived ‘passenger’ dendritic cells have been classically considered as the instigators of acute organ rejection. However, recent advances have revealed that dendritic cells are also involved in the induction/maintenance of peripheral tolerance. This paper briefly reviews the most recent knowledge of the role of donor and recipient dendritic cells during the immune response against allografts, and of the clinical potential of ‘tolerogenic’ dendritic cells.
A study on the probability distribution of the residents load harmonic collective effect based on cloud theory

This paper introduced the cloud theory briefly firstly, then presents a method based on the cloud theory to access the collective harmonic influence of the residential loads, which can identify the harmonic sources so as to determine the harmonic suppression scheme. For the residential harmonic current probability distribution has multiple peak values, the cloud transformation method has more advantages than the normal distribution method. The analysis results of practical cases prove that the cloud transform is capable of fitting the harmonic current distribution curves in high precision, and presenting the multi-modal characteristics of the distribution curves well.
Towards a teleo-social agent category

This paper presents a new category of social agents in multiple agent systems. This new class of agent, named teleo-social agents, is concerned with both maintenance and protection of the group central goal. The knowledge level of the teleo-social agent consists of a) the components, composition laws, behaviour laws and medium of the group, b) the social tasks the agent can apply to it, and c) a social balance-oriented control model. This type of agent is introduced by referring to its use in simulation of development projects.
Nucleotide sequence of the gene encoding the serotype-specific antigen of human (Wa) rotavirus: comparison with the homologous genes from simian SA11 and UK bovine rotaviruses

The nucleotide sequence of human (Wa) rotavirus genome segment 9, which encodes the serotype-specific antigen VP7, has been determined. Comparison of the deduced amino acid sequence of Wa VP7 protein to the sequences of simian SA11 and UK bovine VP7 proteins shows that the majority of the amino acid differences are clustered between amino acid residues 37 through 49, 65 through 75, 87 through 105, 122 through 126, 146 through 149, 178 through 181, and 208 through 242. A hydrophilicity profile of the three proteins reveals correlations between hydrophilic peaks, potentially antigenic determinants, and certain clusters of amino acid changes.
Measure groundwater pumping induced subsidence with D-InSAR

InSAR technology is applied to measuring surface deformation caused by groundwater extraction in this Paper. Cangzhou city, where the most severe ground subsidence in China has occurred, is selected as the work area. Residential, industrial and agricultural water of this region is provided by groundwater pumping and large-area funnel-shape subsidence has formed. Several meters of land subsidence has lead to great damage to urban infrastructure in the past decades. ERS1/2 and JERS-1 SAR data are both collected to detect the deformation in the past few years. This area is seriously affected by the vegetation coverage and large deformation, so the ERS interferograms often contain too much noise except ERS1/2 tandem, which is only preferable for DEM formation. JERS seems to be a little more robust than ERS in this case. Coherence of JERS pairs is not as good as expected, but regional error estimating and appropriate filtering can help to improve the interferogram. Trend and shape and magnitude of the deformation are clear after flattening and unwrapping. Appropriate land use and land cover are considered. And efforts are still being paid to improve processing method to deal with the noise caused by vegetation and atmospheres to get more precise measurements. InSAR technology is expected to be applied in other cities in China to monitor land subsidence induced by groundwater, gas, and oil pumping.
A single episode of neonatal seizures permanently alters glutamatergic synapses

and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997;277:813–817. 20. Casserly I, Topol E. Convergence of atherosclerosis and Alzheimer’s disease: inflammation, cholesterol, and misfolded proteins. Lancet 2004;363:1139–1146. 21. Thompson WD. Effect modification and the limits of biological inference from epidemiologic data. J Clin Epidemiol 1991; 44:221–232. 22. Peters R, Beckett N, Nunes M, et al. A substudy protocol of the hypertension in the Very Elderly Trial assessing cognitive decline and dementia incidence (HYVET-COG): an ongoing randomised, double-blind, placebo-controlled trial. Drugs Aging 2006;23:83–92. 23. Birns J, Markus H, Kalra L. Blood pressure reduction for vascular risk: is there a price to be paid? Stroke 2005;36: 1308–1313. 24. Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006;355:549–559.
Thermal performance of a flux-switching permanent magnet machine for an integrated starter generator in hybrid electric vehicles

This paper investigates the thermal performance of a three-phase 10kW flux-switching permanent magnet (FSPM) machine used as an integrated starter generator (ISG) for hybrid electric vehicles, where the temperature rise experiments are conducted under different operating conditions. Also, the thermal analysis of the FSPM machine is simplified into one-dimensional steady heat conduction with two heat sources in cylindrical coordinates. In addition, an analytic formula for temperature distribution of the FSPM machines is proposed and verified by thermal finite element method (FEM) analysis. Finally, optimizations on the cooling system are conducted by analytical calculations and verified by computational fluid dynamics (CFD) predictions.
Application of “human-in-the-loop” control to a biped walking-chair robot

This paper presents the research on stability for biped walking-chair robot with human-in-the-loop. The inherent properties of the biped system which is developed for the disable people to replace traditional wheelchairs are analyzed. Control of the robot for the gait and navigation is introduced. Posture stability computation method based on ZMP (zero moment point) theory is discussed. Some suggestions about the future research are also presented.
Inhibition of Adrenocortical Carcinoma by Diphtheria Toxin Mutant CRM197

Background: In this study, we investigated the effect of CRM197 treatment in human adrenocortical carcinoma (AC) implanted in nude mice. CRM197 is a non-toxic mutant of diphtheria toxin that binds heparin-binding epidermal growth factor-like growth factor (HB-EGF) which is implicated in the proliferative activity of several tumor cells. Methods: HB-EGF expression in AC cells was evaluated by reverse transcription PCR and Western blot. AC tumors were implanted in nude mice and then treated with CRM197. Effects of treatment on angiogenesis and apoptosis were investigated by immunohistochemistry and Western blot. The effects on cell invasion and migration were investigated with a matrigel invasion assay. Results: We demonstrated that human AC cells express HB-EGF. A treatment with CRM197 blocked growth, reduced angiogenesis and induced apoptosis in AC tumors implanted in nude mice. CRM197 also inhibited invasion and migration of these tumor cells. Conclusions: These data support the evidence for anticancer properties of CRM197 in AC tumors.
[Whole blood citrulline levels in patients with coeliac disease].

UNLABELLED Citrulline is a non-protein amino acid synthesized by the intestine. Whole blood citrulline concentrations in patients with coeliac disease have not been reported. The aim of the study was determination of the amino acid concentrations in coeliacs on gluten-free diet and gluten-containing diet. MATERIAL AND METHODS 61 patients with coeliac disease were studied. Whole blood citrulline were determined in dried blood spots by tandem mass spectrometry. One-way analysis of variance and the Bonferroni post hoc test for multiple comparisons were used to determine differences among groups under study. RESULTS Mean citrulline levels were higher in patients on strict gluten-free diet comparing to those newly diagnosed (32.2 +/- 8.7 vs. 24.9 +/- 5.7 micromol/l; p = 0.025). CONCLUSION Whole blood citrulline concentration may be a simple biochemical marker for diagnosis and monitoring enterocyte loss in coeliac disease.
Clinical Implication of ST Segment Depression in aVR & aVL in Patients with Acute Inferior Wall Myocardial Infarction

Objectives: The aim of the study was to assess the role of ST segment depression in the limb leads aVR and aVL for the diagnosis of acute posterior wall infarction and the identification of infarct related artery (IRA) in patients with acute inferior wall MI. Methods: In 159 patients with I-STEMI, 127 (80%) had RCA occlusion and 32 (20%) had LCX occlusion. In the ECG algorithms, RCA occlusion was indicated by ST depression in lead aVL higher than lead aVR and no ST depression in lead aVL and aVR. LCX occlusion was indicated by ST depression in lead aVR higher than or equal to lead aVL and no ST depression in aVL and aVR. Results: The sensitivity, specificity, positive and negative predictive values of these algorithms were high (98%, 82%, 92% and 95% for RCA occlusion and 83%, 98%, 95% and 92% for LCX occlusion). Conclusion: The ECG algorithms can reliably identify the culprit artery in I-STEMI. ST segment depression in limb leads aVR and aVL with avR ≥ aVL helps to diagnose left circumflex artery as a culprit IRA in an acute inferior wall MI.
Optimizing the use of anti-tumor necrosis factor in the management of patients with Crohn’s disease

Since the approval of the first anti-tumor necrosis factor (anti-TNF) therapy in late 1998, the treatment for Crohn’s disease (CD) has been revolutionized. Anti-TNF therapy has been consistently shown in numerous clinical trials to be effective for patients with more aggressive perianal, internal penetrating, and fistulizing CD. However, the loss of clinical remission is frequent and only one-third of patients remain in clinical remission at 1 year. The pharmacokinetics of anti-TNF is highly variable among patients and could be influenced by many factors including serum albumin, gender, body weight, systemic inflammation and route of administration. The main factor impacting anti-TNF pharmacokinetics and efficacy is the development of immunogenicity where antidrug antibodies accelerate anti-TNF drug clearance. In this review paper, we evaluate the role of combination therapy with anti-TNF drugs and immunomodulators, the role of therapeutic drug monitoring, and strategies to recapture loss of clinical response in order to improve both short- and long-term outcomes in CD patients.
Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas

A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells in normal epithelia, and FGFR3b was localized in the cytoplasm and nucleus in non‐FGFR3b mutant OSCC. Overexpressed FGFR3b protein on plasma membranes was noted in OSCC bearing the FGFR3b mutation. Enhanced tyrosine kinase activity of G697CFGFR3b was confirmed. Our results indicate that G697C is an activating mutation causing constitutive ligand‐independent FGFR3b signaling. This mutation may be involved in the progression of OSCC and thus the FGFR3b coding sequence may have diagnostic or prognostic value for OSCC. © 2005 Wiley‐Liss, Inc.
Modal Analysis of Dissimilar Plate Metal Joining with Different Thicknesses using MIG Welding

This paper presents a study of the dynamic behavior of joining hybrid parts, stainless steel and aluminum alloy, by MIG welding. The objective is to analyze the effect of welding on dissimilar plates of stainless steel and aluminum. A finite element model of joining stainless steel and aluminum alloy by welding was built using a structural threedimensional (3D) solid modeling element. Impact testing using hammer excitation and accelerometer response measuring techniques was conducted to measure the vibration properties of the hybrid parts. The natural frequency and the mode shape graph from experimental modal analysis were then compared with the results that were obtained from finite elements (FE) and showed good agreement. Joining welding gives effect to dynamic properties (mode shape) of modal analysis, especially mode 1,3 (bending pattern) and mode 4 (second twisting). The results show significant points about the effect of MIG welding of dissimilar plate in terms of their dynamic properties compared to welding of the same material. Through comparison of the simulation results and the experimental measurements, it can be assumed that, besides the welding-brazing process, other key manufacturing processes such as cladding, buttering and heat treatment should also be taken into account to accurately predict the dynamic properties in the whole range of dissimilar metal joining.
Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency.

During childhood and young adulthood, the skeleton accrues virtually all the bone mineral it will ever have.1 Since the aging process is associated with bone loss, the more bone mass one gains in the formative years, the less likely it is that increased bone resorption and decreased bone formation will result in osteoporosis. Hence, the failure to achieve optimal peak bone mass is a pathogenetic mechanism in osteoporosis. The sex steroids are critically important in helping to establish peak bone mass for both sexes. Girls with estrogen deficiency do not achieve optimal peak bone mass.2–4 Similarly, achievement of peak .