Miracle-dz/UniFAR-FTUs huggingface dataset:
Do you look where I look? Attention shifts and response preparation following dynamic social cues

Studies investigating the effects of observing a gaze shift in another person often apply static images of a person with an averted gaze, while measuring response times to a peripheral target. Static images, however, are unlike how we normally perceive gaze shifts of others. Moreover, response times might only reveal the effects of a cue on covert attention and might fail to uncover cueing effects on overt attention or response preparation. We therefore extended the standard paradigm and measured cueing effects formore realistic, dynamic cues (video clips),while comparing response times, saccade direction errors and saccade trajectories. Three cues were compared: A social cue, consisting of a eye-gaze shift, and two socially less relevant cues, consisting of a head tilting movement and a person walking past. Similar results were found for the two centrally presented cues (eye-gaze shift and head tilting) on all three response measures, suggesting that cueing is unaffected by the social status of the cue. Interestingly, the cue showing a person walking past showed a dissociation in the direction of the effects on response times on the one hand, and saccade direction errors and latencies on the other hand, suggesting the involvement of two types of (endogenous and exogenous) attention or a distinction between attention and sacadic response preparation. Our results suggest that by using dynamic cues and multiple response measures, properties of cueing can be revealed that would not be found otherwise.
The role of the chlamydial effector CPAF in the induction of genomic instability.

The role of CPAF in chlamydial virulence is justifiably a tangle of confusion. CPAF is a potent and promiscuous cysteine protease capable of cleaving many proteins (Zhong, 2011). Over the 13 years since the original characterization of CPAF in the laboratory of Guaming Zohng (Zhong et al ., 2001) chlamydial researchers have contributed a long list of identified CPAF cleavable target proteins of both chlamydial and host origin (A Conrad et al ., 2013). However, careful studies by the Tan and Sutterlin group convincingly demonstrated that the majority of CPAF activity in infected cells is actually sequestered in the chlamydial inclusion and that biochemical assays relying on cell homogenization in many cases released the sequestered CPAF allowing degradation of ‘targets’ that would not interact with CPAF under biological conditions (Chen et al ., 2012). Thus, the question becomes not what host proteins does CPAF cleave but what host proteins does CPAF have access to and when does it gain this access. New data from the investigation of growth and virulence phenotypes of two mutant strains of chlamydia null for CPAF activity isolated by Emily Snavely in the Valdivia laboratory have added critical observations that have evolved our understanding of the role of CPAF in pathogenesis (Snavely et al ., 2014). The Valdivia laboratory observed that CPAF null strains follow the same developmental cycle and produce normal appearing …
Medical Treatment of Primary Internal Hemorrhoidal and External Hemorrhoidal Disease

The aim of this study was to assess the medical treatment in comparison with hemorrhoidectomy in the management of primary grade-4 internal hemorrhoidal disease (IH) and external hemorrhoidal disease (CH). Group I (medical treatment): 127 patients (59 IH, 68 CH) were prospectively collected and medically treated using oral tablet of micronized purified flavonoid fraction (MPFF) containing 450 mg of diosmin and flavonoids expressed as 50 mg hesperidin, with dosage of 6 tablet per day for 4 days, 4 tablet per day for 3 days, and 2 tablet per day until the signs and symptoms clinically disappear or the end of observation time of 6 weeks. Group II (hemorrhoidectomy): 119 post-hemorrhoidectomy patients (50 IH and 69 CH) were observed with respect to postoperative bleeding, pain, urinary retention, soiling, constipation, recurrence. Statistical calculation using chi-square test to compare the sign and symptom of Group I and Group II. In Group I: the hemorrhoidal piles, bleeding, pain and oozing were progressively decreasing, and all complaints finally disappeared between 1 and 6 weeks without any MPFF’s adverse reaction. In Group II: postoperative bleeding, pain, soiling, urinary retention, and constipation were noted. It showed as ignificant outcome in Group I in comparison with Group II (bleeding, p=0.012; pain, p=0.000), soiling, urinary retention, anal stenosis and constipation.
The design of sum-of-cisoids rayleigh fading channel simulators assuming non-isotropic scattering conditions

In this letter, we introduce the Riemann sum method (RSM) as an effective tool for the design of sum-of-cisoids (SOC) simulators for narrowband mobile Rayleigh fading channels under non-isotropic scattering conditions. We compare the performance of the RSM with that of the generalized method of equal areas (GMEA) and the Lp-norm method (LPNM), which were until now the only methods available for the design of SOC simulators for non-isotropic scattering channels. The obtained results indicate that the RSM is better suited than the GMEA and the LPNM to emulate the channel's autocorrelation function (ACF), whereas the latter two methods are more precise regarding the approximation of the envelope distribution. The results also show that the benefits of increasing the number of cisoids are more significant in the case of the RSM than in the case of the GMEA and LPNM. Owing to its simplicity and good performance, the RSM can be used to design flexible simulation platforms for the laboratory analysis of mobile communication systems operating in non-isotropic scattering environments.
Immunophenotyping of interstitial infiltrate does not distinguish between BK virus nephropathy and acute cellular rejection

Introduction: BK virus nephropathy (BKVN) is a significant cause of late renal allograft loss. It is characterized histologically by an interstitial nephritis that can be difficult to distinguish from acute cellular rejection (ACR). We investigated whether immunophenotyping of the infiltrate would aid this distinction.
Lessons from mouse models of thyroid cancer.

BACKGROUND Thyroid cancer is the most common endocrine tumor and is increasing in incidence. The aim of this study was to review mouse models of differentiated thyroid cancer and how they elucidate human thyroid cancer biology. SUMMARY Differentiated thyroid cancer, primarily papillary and follicular, comprises the majority of thyroid cancers. There has been tremendous growth in the cross-talk between basic science and clinical practice for thyroid cancer management. Insight into the framework of genes responsible for differentiated thyroid cancer has been gained through the use of mouse models. Common genetic alterations found in human papillary thyroid cancer such as RET/PTC rearrangements or the BRAF(V600E) mutation have genetically modified mouse counterparts. These and other preclinical mouse models have validated the importance of the cyclic adenosine monophosphate (cAMP)/protein kinase A and mitogen-activated protein kinase (MAPK) signaling pathways in papillary thyroid cancer (PTC). RAS mutations have a role in both papillary and follicular thyroid cancer development. Mice with overactivation of the phosphatidylinol-3-kinase (PI3K)-AKT and/or thyrotropin-regulated signaling pathways have been found to develop follicular thyroid cancer. Additional mouse models of thyroid cancer that utilize inducible expression systems are in development or are being characterized and will better reflect the majority of human thyroid cancers which are non-hereditary. Advances in in vivo imaging of mice allow for earlier detection of metastasis and the ability to follow tumor growth or regression which may be used in evaluation of pharmaceutical agents. CONCLUSIONS Mouse models have expanded our understanding of the altered signaling pathways that contribute to thyroid cancer tumorigenesis and provide a powerful tool to develop novel diagnostic approaches and therapies.
On XPM Mitigation in WDM Fiber-Optic Systems

The impact and possible mitigation of interchannel nonlinearity is investigated in single-polarization wavelength-division multiplexing systems by evaluating, both analytically and by simulation, the achievable information rate for a Gaussian-modulated channel surrounded by Gaussian- or constant-envelope-modulated channels. Different number of channels, link configurations, and mitigation strategies are considered. It turns out that a Kalman equalizer can be effective in the ideal case of distributed amplification but fails for practical systems with long spans and lumped amplification.
SMALL SIGNAL STABILITY ANALYSIS USING FUZZY CONTROLLER AND ARTIFICIAL NEURAL NETWORK STABILIZER

Power system Stabilizers are used in order to damp out the low frequency oscillations which are due to disturbances. This paper attempts to investigate the performance of Conventional Power System Stabilizer (CPSS), Fuzzy Logic Power System Stabilizer (FLPSS) and Artificial Neural Network based Power System Stabilizer (ANNPSS) under Prefault and Postfault conditions for different loadings. The parameters of Conventional Power System Stabilizer (CPSS) is designed using Pole-Placement Technique and the parameters of Fuzzy logic Power System Stabilizer (FLPSS) is tuned to their optimal values in order to minimize the overshoot in step response of rotor angle
Comparison of O-Linked Carbohydrate Chains in MUC-1 Mucin from Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines:

MUC-1 mucin is considered to be aberrantly glycosylated in breast, ovary, and other carcinomas in comparison with mucin from corresponding normal tissues. In order to clarify these differences in glycosylation, we have compared the O-linked carbohydrate chains from MUC-1 immunoprecipitated from [3H]GlcN-labeled breast epithelial cell lines (MMSV1-1, MTSV1-7, and HB-2) derived from cells cultured from human milk, with three breast cancer cell lines (MCF-7, BT-20, and T47D). Analysis by high pH anion chromatography showed that the normal cell lines had a higher ratio of GlcN/GalN and more complex oligosaccharide profiles than the cancer cell lines. Structural analyses were carried out on the oligosaccharides from MTSV1-7 and T47D MUC-1, and the following structures were proposed. MUC-1 from T47D had rather a simple glycosylation pattern, with NeuAcα2-3Galβ1-3GalNAc-ol, Galβ1-3GalNAc-ol, and GalNAc-ol predominating; in contrast, MUC-1 from MTSV1-7 had more complex structures, including a number of disialo, core 2 species, i.e. NeuAcα2-3Galβ1-4GlcNAcβ1-6[NeuAcα2-3Galβ1-3]GalNAc-ol and NeuAcα2-3Galβ1-4GlcNAcβ1-6[NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-3]GalNAc-ol. Double-labeling experiments with [3H]GlcN and 14C-aminoacids and analysis of GalNAc or GalNAc-ol:protein ratios in MUC-1 showed that there was also a significant difference in the degree of glycosylation of the mucin between the two cell types. We conclude that MUC-1 from breast cancer cell lines has simpler, and fewer, carbohydrate chains than MUC-1 from normal breast epithelial cells, and that these differences, combined or separately, explain the differential tumor specificity of some MUC-1 antibodies and T cells.
ON THE RELATIONSHIP BETWEEN ABUNDANCE AND DISTRIBUTION OF SPECIES

How environmental conditions and population processes determine the abundance and distribution of species is a central problem of ecology and biogeography. Although it has long been recognized that abundance and distribution are intimately interrelated, the nature of this relationship has not been investigated systematically over the range of spatial scales from local populations to entire geographic ranges of species. On a local scale, i.e., the small habitat patches that constitute most ecologists' study areas, the relationship between population density and spatial distribution of individuals has been studied by many population and community ecologists (e.g., Andrewartha and Birch 1954; Krebs 1978, and numerous references therein). Distribution on a large geographic scale has usually been regarded as the special province of biogeography, whose practitioners often have little experience or interest in population ecology (but see, e.g., Grinnell 1922; MacArthur 1972; Walter 1979; Rapoport 1982; Brown and Gibson 1983). Thus few investigators have systematically studied variation in population density over the geographic range of species. Recently, however, several authors have presented data that suggest a general relationship between local population density and spatial distribution on a geographic scale (e.g., Rabinowitz 1981; Hanski 1982a, 1982b, 1982c; Bock and Ricklefs 1983; J. T. Emlen et al., MS). Here I reanalyze and synthesize some of the diverse information available on the relationship between abundance and distribution. These data suggest extremely general patterns within and among species that appear to hold for organisms as diverse as vascular plants, intertidal invertebrates, terrestrial arthropods, planktonic crustaceans, and terrestrial vertebrates. I develop a general theory to explain these relationships. This conceptual construct and the empirical observations that motivated it focus attention on problems that span the boundaries between the traditional disciplines of population ecology, community ecology, biogeography, population genetics, and evolution. Clarification of terminology should facilitate understanding of what follows. The paper is concerned with the relationship between two attributes of populations and species: the density of individuals within a local area and the extent of the distribution of individuals in space. I shall often use the term abundance to
Upper Extremity Function and Occupational Performance in Children With Spastic Cerebral Palsy Following Lower Extremity Botulinum Toxin Injections

We studied the effect of botulinum toxin A injections to the lower extremities of spastic cerebral palsy children on upper limb body function and occupational performance. A total of 16 children with spastic cerebral palsy, aged 2 to 8 years, Gross Motor Function Classification System levels I-IV, referred to a child neurology outpatient clinic for botulinum toxin A injections to the lower limbs, underwent 4 assessments: 1 month prior to injection, immediate pre injection, and at 1 and 5 to 6 months post injection. Three tools were used to test everyday function (Canadian Occupational Performance Measure and the Pediatric Evaluation of Disability Inventory) and upper extremity body function (Quality of Upper Extremity Skills Test). Significant improvement was documented between the immediate preinjection and the 2 postinjection assessments, indicating that improvement lasted for at least 6 months. Botulinum toxin A injections to the lower extremities in children with cerebral palsy improve upper limb body function and occupational performance.
Conception de réseaux de distribution pour une personnalisation produit : une contextualisation à l'échelle du continent Africain

Face a la forte concurrence internationale, de nombreuses entreprises manufacturieres orientent leurs investissements vers les marches africains pour accroitre leur part de marche et rester competitives sur le marche mondial. Ces marches sont effet en plein essor mais demandent des produits de grande diversite. En depit de cette attractivite, les flux commerciaux en Afrique demeurent faibles en raison de la faible qualite des infrastructures et de l’absence d’ecosystemes logistiques regionaux connectant les pays africains de maniere fiable et efficace.C’est pourquoi cette these de doctorat s’interesse a la modelisation et a la resolution du probleme de conception de reseaux de distribution hybrides en Afrique, integrant des plateformes de distribution et de personnalisation finale des produits. Ces reseaux incluent, en amont, des hubs regionaux servant de porte d’entree vers les marches d’une region continentale. Le report de la personnalisation finale en aval du reseau logistique permet de reduire les delais de livraison aux marches et le cout de distribution tout en maintenant une economie d’echelle. La methodologie que nous proposons repose sur deux grands axes de recherche :▪ Le premier axe vise a definir la localisation des hubs logistiques regionaux, sur la base d’une analyse multicriteres floue, version amelioree de TOPSIS floue et d'AHP ;▪ Le deuxieme axe aborde conception de reseaux de distribution hybrides servant des marches fortement diversifies (exemple : marches des engrais). Nous avons propose deux nouveaux modeles d'optimisation multi-objectifs minimisant le cout total d’exploitation et d’investissement, maximisant la proximite des produits aux marches et minimisant les dommages sur les produits finis durant leur distribution. Le premier modele est deterministe tandis que le deuxieme propose une conception flexible alignee sur la dynamique et l’incertitude de l’evolution des marches africains.
Paranasal Manifestations of Early Stage Chronic Lymphocytic Leukemia

GEREÇ VE YÖNTEMLER: Bu çalışma 40 hastayı içeren bir klinik çalışma olarak yapılmıştır. Grup KLL (n=20) herhangi bir tedavi almamış hematoloji kliniği tarafından takip edilen erken evre KLL hastalarından oluşturuldu. Kontrol grubu (n=20) burun tıkanıklığı nedeniyle konka cerrahisi geçirmiş hastalardan oluşturuldu. Tüm hastaların paranazal sinus tomografileri çekilip Lund Mackay sistemine gore skorlandı ve sinüzit bulguları kaydedildi. Tüm hastaların alt konka başından alınan biyopsi materyalleri, NF-kB and TNF-α primer antikorları ile immünohistokimyasal olarak boyandı.
Personal monitoring technique for mercury vapor in air and determination by flameless atomic absorption.

A method is described for the collection of air samples containing mercury vapor and subsequent determination by cold vapor atomic absorption (AA) analysis. The mercury vapor is trapped in a small glass tube containing hopcalite granules. Mercury is removed from the hopcalite by treatment with nitric acid. The mercury is reduced to elemental form with stannous chloride and the determination is completed by cold vapor atomic absorption, using either an AA spectrophotometer or a mercury vapor detector. Nanogram quantities of mercury can be measured accurately, using a minimum of field sampling equipment. Since air sample volume is unlimited, the method can be applied to a wide range of vapor concentrations. In addition to personal monitoring, stack and community air quality measurements can be performed with this technique.
Apport des réseaux de capteurs connectés au suivi des cultures.

Acquerir de maniere tres reguliere des observations au cœur des parcelles et les valoriser en elements d’aide a la decision pour l’ensemble des parcelles d’un territoire est un element essentiel pour faciliter le travail des acteurs du monde agricole. A ce titre, les Reseaux de Capteurs Sans Fil (RCSF) sont une des technologies les plus prometteuses car ils sont complementaires des solutions existantes (satellites, capteurs embarques, stations meteorologiques), qui presentent des resolutions spatiales ou temporelles trop faibles. Afin de repondre aux limites actuelles des outils d’aide a la decision agricoles, l’objectif general du projet est de concevoir, mettre en œuvre et evaluer un systeme d’information complet, allant de l’installation d’un RCSF operationnel, jusqu’au conseil a l’agriculteur ou au technicien. Mis en œuvre en Champagne-Ardenne, le projet Casdar CROCUS a permis d’evaluer l’interet technique et economique de cette technologie, mais aussi de dresser un panorama des perspectives pour l’amelioration des conseils aux agriculteurs. A ce titre, CROCUS est une implementation pionniere de l’Internet des objets (IoT) dans les parcelles agricoles.
Modeling and identification of the nociceptive system using psychophysical measurements

Efficient treatment for pain disorders could benefit from improved diagnostic tools by identifying defective nociceptive processes. To develop such a tool, this thesis follows a system approach by building plausible computational models. To offer a mechanism-based interpretation, we perform mathematical analysis on these models. In particular, we use psychophysical measurements from human subjects to perform parameter estimation and identifiability analysis. We start with building neurophysiology-based models, representing both peripheral and central nociceptive subsystems for a nociceptive detection task using electrocutaneous stimulation. In addition, we incorporate psychophysical observations of detection thresholds for a qualitative validation. In turn, it provides explanatory insights into the underlying mechanisms. In particular, our analysis reveals that the observed dependence of thresholds on the interpulse interval of double-pulse stimuli could be attributed to specific properties in central nociceptive subsystems. Next, with the developed model, we investigate nociceptive neuroplasticity. In a case study using a topical capsaicin patch, simulation results agree with observations qualitatively, and suggest that capsaicin-induced central neuroplasticity can last over a month. For a more quantitative assessment of the nociceptive system, we address estimation and identifiability of system parameters with stimulus-response pairs measured from individual subjects. A necessary condition for structural identifiability on stimulus properties follows from our theoretical analysis. Our study demonstrates the applicability of profile likelihood to assess identifiability in a nonlinear physiology-based model using psychophysical measurements. Further applications of our approach might facilitate mechanism-based differential diagnosis of malfunctioning nociceptive processes. We formulate the staircase procedures utilized in the experimental detection task as Markov models. Both our theoretical analysis and simulations reveal the existence of a bias in the threshold estimate from logistic regression. This finding also suggests that in order to estimate system parameters, one should use measured stimulus-response pairs rather than intermediate threshold estimates. Lastly, with respect to computational modeling and analysis, we point out prospective research directions including modeling of other relevant nociceptive processes as well as possible integration with other psychophysical measurements. We discuss how possible usage of the developed computational tools might advance our understanding of pain disorders towards clinical diagnosis to differentiate malfunctioning subsystems.
Characterization of Seed Storage Proteins from Chickpea Using 2D Electrophoresis Coupled with Mass Spectrometry

Proteomic analysis was employed to map the seed storage protein network in landrace and cultivated chickpea accessions. Protein extracts were separated by two-dimensional gel electrophoresis (2D-GE) across a broad range 3.0–10.0 immobilized pH gradient (IPG) strips. Comparative elucidation of differentially expressed proteins between two diverse geographically originated chickpea accessions was carried out using 2D-GE coupled with mass spectrometry. A total of 600 protein spots were detected in these accessions. In-gel protein expression patterns revealed three protein spots as upregulated and three other as downregulated. Using trypsin in-gel digestion, these differentially expressed proteins were identified by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) which showed 45% amino acid homology of chickpea seed storage proteins with Arabidopsis thaliana.