Miracle-dz/UniFAR-FTUs huggingface dataset:
Life insurance and demographic change: An empirical analysis of surrender decisions based on panel data

Households buy life insurance as part of their liquidity management. The option to surrender such a policy can serve as a buffer when a household faces a liquidity need. In this study, we investigate empirically which individual and household specific sociodemographic factors influence the surrender behavior of life insurance policyholders. Based on the Socio-Economic Panel (SOEP), an ongoing wide-ranging representative longitudinal study of around 11,000 private households in Germany, we construct a proxy to identify life insurance surrender in the data. We use this proxy to conduct fixed effect regressions and support the results with survival analyses. We find that life events that possibly impose a liquidity shock to the household, such as birth of a child and divorce increase the likelihood to surrender an existing life insurance policy for an average household in the panel. The acquisition of a dwelling and unemployment are further aspects that can foster life insurance surrender. Our results are robust with respect to different models and hold conditioning on region specific trends; they vary however for different age groups. Our analyses contribute to the existing literature supporting the emergency fund hypothesis. The findings obtained in this study can help life insurers and regulators to detect and understand industry specific challenges of the demographic change.
Porphyromonas gingivalis Peptidyl Arginine Deiminase Can Modulate Neutrophil Activity via Infection of Human Dental Stem Cells

Periodontitis (PD) is a widespread chronic inflammatory disease in the human population. Porphyromonas gingivalis is associated with PD and can citrullinate host proteins via P. gingivalis peptidyl arginine deiminase (PPAD). Here, we hypothesized that infection of human dental follicle stem cells (hDFSCs) with P. gingivalis and subsequent interaction with neutrophils will alter the neutrophil phenotype. To test this hypothesis, we established and analyzed a triple-culture system of neutrophils and hDFSCs primed with P. gingivalis. Mitogen-activated pathway blocking reagents were applied to gain insight into stem cell signaling after infection. Naïve hDFSCs do not influence the neutrophil phenotype. However, infection of hDFSCs with P. gingivalis prolongs the survival of neutrophils and increases their migration. These phenotypic changes depend on direct cellular contacts and PPAD expression by P. gingivalis. Active JNK and ERK pathways in primed hDFSCs are essential for the phenotypic changes in neutrophils. Collectively, our results confirm that P. gingivalis modifies hDFSCs, thereby causing an immune imbalance.
Evidence-informed policy making at country level: lessons learned from the South African Tuberculosis Think Tank

BACKGROUND: National Tuberculosis Programmes (NTPs) require specialist input to support the development of policy and practice informed by evidence, typically against tight deadlines. OBJECTIVE: To describe lessons learned from establishing a dedicated tuberculosis (TB) think tank to advise the South African NTP on TB policy. INTERVENTION AND EVALUATION METHODS: A national TB think tank was established to advise the NTP in support of evidence-informed policy. Support was provided for activities, including meetings, modelling and regular telephone calls, with a wider network of unpaid expert advisers under an executive committee and working groups. Intervention evaluation used desktop analysis of documentary evidence, interviews and direct observation. RESULTS: The TB Think Tank evolved over time to acquire three key roles: an ‘institution’, a ‘policy dialogue forum’ and an ‘interface’. Although enthusiasm was high, motivating participation among the NTP and external experts proved challenging. Motivation of working groups was most successful when aligned to a specific need for NTP decision making. Despite challenges, the TB Think Tank contributed to South Africa's first ever TB and human immunodeficiency virus (HIV) investment case, and the decision to create South Africa's first ever ring-fenced grant for TB. The TB Think Tank also assisted the NTP in formulating strategy to accelerate progress towards reaching World Health Organization targets. DISCUSSION: With partners, the TB Think Tank achieved major successes in supporting evidence-informed decision making, and garnered increased funding for TB in South Africa. Identifying ways to increase the involvement of NTP staff and other experts, and keeping the scope of the Think Tank well defined, could facilitate greater impact. Think tank initiatives could be replicated in other settings to support evidence-informed policy making.
Influence of Maximal Strength on In-Water and Dry-Land Performance in Young Water Polo Players.

Keiner, M, Rähse, H, Wirth, K, Hartmann, H, Fries, K, and Haff, GG. Influence of maximal strength on in-water and dry-land performance in young water polo players. J Strength Cond Res XX(X): 000-000, 2018-Water polo is a multifaceted sport that is characterized by explosive actions, including sprint swimming, jumping, throwing, and struggling against opponents. Based on these factors, maximal and speed strength may be important characteristics to develop in-water polo players. However, more research is needed to further understand the relationship between various strength characteristics and water polo performance. Therefore, the primary purpose of this study was to examine the relationships between strength, speed strength, and markers of water polo performance in youth water polo players. Sixty-one male youth water polo players (10-14 years, 11.9 ± 1.3 years) had their 1-repetition maximum (1RM) bench press and squat, dry-land speed-strength performance (squat jump [SJ], countermovement jump [CMJ], and medicine ball throw), in-water performance (sprint swim and water jump), and anthropometric measurements assessed. Fifty to 60% of the variance in sprint performance was explained by the 1RM bench press and arm span. The influence of the bench press 1RM was more than twice that of the anthropometric factors. Maximum strength in the squat and speed-strength (jump height in SJ, CMJ) variables explained 18-25% variance in the eggbeater kick (a leg strike technique to stay above and jump out of water), and the bench press 1RM explained the 42% of the variance in loaded throws without the influence of anthropometric factors. This study suggests that upper- and lower-body maximal strength parameters are important predictors of the performance capacity of water polo players.
Epidemiology and patient characteristics of hepatitis D virus infection in the West of Scotland 2011‐2016

Worldwide 15-20 million individuals are infected with hepatitis delta virus (HDV) [1] . It is a small, single stranded RNA virus that is only able to infect individuals also infected with hepatitis B (HBV). It is transmitted sexually, via blood and perinatally. Those who are co-infected with HBV and HDV are at greater risk of liver fibrosis, earlier hepatic decompensation, liver cirrhosis and have an increased risk of hepatocellular carcinoma compared to those with HBV alone [1] . The only effective treatment for HDV is pegylated interferon. This article is protected by copyright. All rights reserved.
Nonuniform impacts of forward suppression on neural responses to preferred stimuli and nonpreferred stimuli in the rat auditory cortex

In natural conditions, human and animals need to extract target sound information from noisy acoustic environments for communication and survival. However, how the contextual environmental sounds impact the tuning of central auditory neurons to target sound source azimuth over a wide range of sound levels is not fully understood. Here, we determined the azimuth‐level response areas (ALRAs) of rat auditory cortex neurons by recording their responses to probe tones varying with levels and sound source azimuths under both quiet (probe alone) and forward masking conditions (preceding noise + probe). In quiet, cortical neurons responded stronger to their preferred stimuli than to their nonpreferred stimuli. In forward masking conditions, an effective preceding noise reduced the extents of the ALRAs and suppressed the neural responses across the ALRAs by decreasing the response strength and lengthening the first‐spike latency. The forward suppressive effect on neural response strength was increased with increasing masker level and decreased with prolonging the time interval between masker and probe. For a portion of cortical neurons studied, the effects of forward suppression on the response strength to preferred stimuli was weaker than those to nonpreferred stimuli, and the recovery from forward suppression of the response strength to preferred stimuli was earlier than that to nonpreferred stimuli. We suggest that this nonuniform forward suppression of neural responses to preferred stimuli and to nonpreferred stimuli is important for cortical neurons to maintain their relative stable preferences for target sound source azimuth and level in noisy acoustic environments.
An Adaptive Priority-Based Heuristic Approach for Scheduling DAG Applications with Uncertainties

In the context of large-scale distributed computing environments, among various DAG scheduling heuristics aiming at coping with severe uncertainties during task execution, those ones that try to maximize the parallelism of ready tasks seems to be promising. However, most of such heuristics consider only the DAG structure when making scheduling decision. When the information about task execution time (even though might be inaccurate) is given, it might be interesting to investigate whether this information should be taken into account during scheduling, and if yes, how to. This paper presents an adaptive priority-based heuristic, which properly considers the task execution time estimate and the DAG structure attributes in the task prioritization. The evaluation result shows the proposed approach obtains better scheduling performance than existing solutions.
Relevance of Aβ42/40 Ratio for Detection of Alzheimer Disease Pathology in Clinical Routine: The PLMR Scale

Background: Cerebrospinal fluid (CSF) biomarkers (Aβ peptides and tau proteins) improved the diagnosis of Alzheimer’s disease (AD) in research and clinical settings. We previously described the PLM-scale (Paris-Lille-Montpellier study), which combines Aβ42, tau, and phosphorylated ptau(181) biomarkers in an easy to use and clinically relevant way. The purpose of this work is to evaluate an optimized PLMR-scale (PLM ratio scale) that now includes the Aβ42/Aβ40 ratio to detect AD versus non-AD (NAD) participants in clinical routine of memory centers. Methods: Both scales were compared using 904 participants with cognitive impairment recruited from two independent cohorts (Mtp-1 and Mtp-2). The CSF Aβ42/Aβ40 ratio was measured systematically in Mtp-1, and only on biologically discordant cases in Mtp-2. Two different ELISA kit providers were also employed. The distribution of AD and NAD patients and the discrepancies of biomarker profiles were computed. Receiver Operating Characteristic curves were used to represent clinical sensitivity and specificity for AD detection. The classification of patients with the net reclassification index (NRI) was also evaluated. Results: Nine hundred and four participants (342 AD and 562 NAD) were studied; 400 in Mtp-1 and 504 in Mtp-2. For AD patients, the mean CSF Aβ42 and CSF Aβ42/40 ratio was 553 ± 216 pg/mL and 0.069 ± 0.022 pg/mL in Mtp-1 and 702 ± 335 pg/mL and 0.045 ± 0.020 pg/mL in Mtp-2. The distribution of AD and NAD differed between the PLM and the PLMR scales (p < 0.0001). The percentage AD well-classified (class 3) increased with PLMR from 38 to 83% in Mpt-1 and from 33 to 53% in Mpt-2. A sharp reduction of the discordant profiles going from 34 to 16.3% and from 37.5 to 19.8%, for Mtp-1 and Mtp-2 respectively, was also observed. The AUC of the PLMR scale was 0.94 in Mtp-1 and 0.87 in Mtp-2. In both cohorts, the PLMR outperformed CSF Aβ42 or Aβ42/40 ratio. The diagnostic performance was improved with the PLMR with an NRI equal to 44.3% in Mtp-1 and 28.8% in Mtp-2. Conclusion: The integration of the Aβ42/Aβ40 ratio in the PLMR scale resulted in an easy-to-use tool which reduced the discrepancies in biologically doubtful cases and increased the confidence in the diagnosis in memory center.
A time domain classification of steady-state visual evoked potentials using deep recurrent-convolutional neural networks

Steady-State Visual Evoked Potential (SSVEP) is one of the popular methods of brain-computer interfacing (BCI). It is used to translate the Electroencephalogram (EEG) signals into actions or choices. The main challenge in processing the SSVEP signal recognition is finding an appropriate intermediate representation to facilitate the classification task afterwards. In the literature, frequency domain analysis was extensively adopted as an intermediate representation for SSVEP classification. In this presented paper, we propose a deep learning model that uses a hybrid architecture based on Convolutional and Recurrent Neural Networks to classify SSVEP signals in the time domain directly. We achieved accuracy 93.59% compared to 87.40% for the state-of-the-art method: canonical correlation analysis in the frequency domain. The proposed architecture facilitates the real-time classification of SSVEP signals in the time domain for real-time applications such as robot cars and exoskeletons.
Value of Free-text Comments for Validating Cancer Cases Using Primary-care Data in the United Kingdom.

© 2018 Wolters Kluwer Health, Inc. All rights reserved. www.epidem. com | e41 Reproducibility: The results of the study were generated by RTI Health Solutions (RTI-HS) using data obtained from CPRD. RTI-HS developed proprietary code to perform the analyses on the data. Researchers desiring access to the data would be required to obtain permission from the study sponsor, obtain data use agreement with CPRD, and develop their own code. This study was funded by Astellas Pharma Global Development, Inc. The contract provides the research team independent publication rights. A.M., J.F. , J.K. , B.C., M.R. , E.P., L.M. , S.P.-G. , and A.A. are employees of RTI International, an independent, nonprofit research organization that does work for government agencies and pharmaceutical companies. W.J.A. , B.F. , and S.d. V. are employees of Astellas Pharma Global Development, the sponsors of this study. Value of Free-text Comments for Validating Cancer Cases Using Primarycare Data in the United Kingdom
LUBAC and ABIN-1 Modulate TRAIL-Based NF-κB Induction in Human Embryonic Kidney 293 Cells

Abstract Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to activate the canonical NF-κB pathway similar to TNF. The exact mechanism of the entire signaling cascade is still under investigation. The involvement of linear ubiquitylation as upregulating component has already been shown recently in some cell lines, but not in human embryonic kidney 293 (HEK293) cells. The downregulating function of the ABIN-1 (A20 binding and inhibitor of NF-κB) as linear ubiquitylation antagonist has been shown in combination with some NF-κB-inducing pathways, but not with TRAIL. We performed luciferase and western blot assays using HEK293 cells stimulated with either TRAIL (or TNF as a control) to analyze the involvement of linear ubiquitin chain assembly complex (LUBAC) components and the impact of ABIN-1 and ABIN-1-MAD (truncated form without A20 binding site) on NF-κB signaling. For overexpression experiments, we added plasmids of ABIN-1 and ABIN-1-MAD or LUBAC components HOIP, HOIL-1, or SHARPIN (single and combinations). For downregulation experiments five pairs of either SHARPIN, HOIL-1, or HOIP targeting miRNAs or one miRNA for ABIN-1 were designed and added. ABIN-1 and its truncated form ABIN-1-MAD reduced the NF-κB induction significantly indicating its involvement as antagonist (independent of deubiquitinase A20) of linear ubiquitylation in TRAIL-induced NF-κB signaling. In opposition, knockdown of ABIN-1 using a specific ABIN-1 miRNA led a clear increase of NF-κB signaling. Addition of single LUBAC components or combinations (except for SHARPIN with HOIL-1) resulted in clearly stronger NF-κB inductions. MiRNAs targeting LUBAC components significantly reduced NF-κB activation. Thus, in HEK293 cells linear ubiquitylation by LUBAC critically upregulates and ABIN-1 downregulates TRAIL-induced NF-κB signaling and may be interesting targets for future pathological therapies.
A Tighter Set-Membership Filter for Some Nonlinear Dynamic Systems

In this paper, we propose a tighter set-membership filter for some nonlinear dynamic systems by using an analytic method and a boundary sampling technique. The nonlinear dynamic systems can be linearized about the current estimate, then the remainder term is bounded in real time by an optimization ellipsoid, other than a priori remainder bound. For a 2-D radar system and a quadratic system, some regular properties can be derived for the remainder term, which helps us obtain a tighter bounding ellipsoid to cover the remainder. Moreover, the prediction step and the measurement update step are derived based on the recent optimization method and the on-line bounding ellipsoid of the remainder, so that a tighter set-membership filter can be achieved. The numerical examples demonstrate the effectiveness of the proposed filter.
Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides

We introduce a new class of semisynthetic fluorescent biosensors for the quantification of free nicotinamide adenine dinucleotide (NAD+) and ratios of reduced to oxidized nicotinamide adenine dinucleotide phosphate (NADPH/NADP+) in live cells. Sensing is based on controlling the spatial proximity of two synthetic fluorophores by binding of NAD(P) to the protein component of the sensor. The sensors possess a large dynamic range, can be excited at long wavelengths, are pH-insensitive, have tunable response range and can be localized in different organelles. Ratios of free NADPH/NADP+ are found to be higher in mitochondria compared to those found in the nucleus and the cytosol. By recording free NADPH/NADP+ ratios in response to changes in environmental conditions, we observe how cells can react to such changes by adapting metabolic fluxes. Finally, we demonstrate how a comparison of the effect of drugs on cellular NAD(P) levels can be used to probe mechanisms of action.
A global regulatory system links virulence and antibiotic resistance to envelope homeostasis in Acinetobacter baumannii

The nosocomial pathogen Acinetobacter baumannii is a significant threat due to its ability to cause infections refractory to a broad range of antibiotic treatments. We show here that a highly conserved sensory-transduction system, BfmRS, mediates the coordinate development of both enhanced virulence and resistance in this microorganism. Hyperactive alleles of BfmRS conferred increased protection from serum complement killing and allowed lethal systemic disease in mice. BfmRS also augmented resistance and tolerance against an expansive set of antibiotics, including dramatic protection from β-lactam toxicity. Through transcriptome profiling, we showed that BfmRS governs these phenotypes through global transcriptional regulation of a post-exponential-phase-like program of gene expression, a key feature of which is modulation of envelope biogenesis and defense pathways. BfmRS activity defended against cell-wall lesions through both β-lactamase-dependent and -independent mechanisms, with the latter being connected to control of lytic transglycosylase production and proper coordination of morphogenesis and division. In addition, hypersensitivity of bfmRS knockouts could be suppressed by unlinked mutations restoring a short, rod cell morphology, indicating that regulation of drug resistance, pathogenicity, and envelope morphogenesis are intimately linked by this central regulatory system in A. baumannii. This work demonstrates that BfmRS controls a global regulatory network coupling cellular physiology to the ability to cause invasive, drug-resistant infections.
The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors

Fungi, usually present as commensals, are a major cause of opportunistic infections in immunocompromised patients. Such infections, if not diagnosed or treated properly, can prove fatal. However, in most cases healthy individuals are able to avert the fungal attacks by mounting proper antifungal immune responses. Among the pattern recognition receptors (PRRs), C-type lectin receptors (CLRs) are the major players in antifungal immunity. CLRs can recognize carbohydrate ligands, such as β-glucans and mannans, which are mainly found on fungal cell surfaces. They induce proinflammatory immune reactions, including phagocytosis, oxidative burst, cytokine, and chemokine production from innate effector cells, as well as activation of adaptive immunity via Th17 responses. CLRs such as Dectin-1, Dectin-2, Mincle, mannose receptor (MR), and DC-SIGN can recognize many disease-causing fungi and also collaborate with each other as well as other PRRs in mounting a fungi-specific immune response. Mutations in these receptors affect the host response and have been linked to a higher risk in contracting fungal infections. This review focuses on how CLRs on various immune cells orchestrate the antifungal response and on the contribution of single nucleotide polymorphisms in these receptors toward the risk of developing such infections.
Martian plate tectonics

The northern lowlands of Mars may have been produced by plate tectonics. Preexisting old thick highland crust was subducted, while seafloor spreading produced thin lowland crust during Late Noachian and Early Hesperian time. In the preferred reconstruction, a breakup margin extended north of Cimmeria Terra between Daedalia Planum and Isidis Planitia where the highland-lowland transition is relatively simple. South dipping subduction occurred beneath Arabia Terra and east dipping subduction beneath Thatsis Montes and Tempe Terra. Lineations associated with Gordii Dotsum are attributed to ridge-parallel structures, while Phelegra Montes and Scandia Colles are interpreted as transform-parallel structures or ridge-fault-fault triple junction tracks. Other than for these few features, there is little topographic roughness in the lowlands. Seafloor spreading, if it occurred, must have been relatively rapid. Quantitative estimates of spreading rate are obtained by considering the physics of seafloor spreading in the lower C 0.4 g) gravity of Mars, the absence of vertical scarps from age differences across fracture zones, and the smooth axial topography. To the first order, the height of vertical scarps across fracture zones does not involve gravity. Crustal thickness at a given potential temperature in the mantle source region scales inversely with gravity. Thus, the velocity of the rough-smooth transition for axial topography also scales inversely with gravity. Plate reorganizations where young crust becomes difficult to subduct are another constraint on spreading age. Possible plate reorganizations, for example, the end of spreading through Alba Patera, occur when the ridge axis is far from the trench. That is, rapid plate motions are inferred to have placed young oceanic crust far from the ridge axis. The preferred full spreading rate 900 from the plate pole is 80 mm yr -1. Plate tectonics, if it occurred, dominated the thermal and stress history of the planet. A geochemical implication is that the lower gravity of Mars allows deeper hydrothermal circulation through cracks and hence more hydration of oceanic crust so that more water is easily subducted than on the Earth. Age and structural relationships from photogeology as well as median wavelength gravity anomalies across the now dead breakup and subduction margins are the data most likely to test and modify hypotheses about Mars plate tectonics.