Miracle-dz/UniFAR-FTUs huggingface dataset:
Trends in Adolescent Substance Use and Perception of Risk from Substance Use

An adolescent’s perception of the risks associated with substance use is an important determinant of whether he or she engages in substance use. For example, youths who perceive high risk of harm are less likely to use drugs than youths who perceive low risk of harm.1 Thus, providing adolescents with credible, accurate, and age-appropriate information about the harm associated with substance use is a key component in prevention programming.2 Expanding upon research that shows the predictive nature of risk perceptions to subsequent substance use among adolescents,3,4 the National Survey on Drug Use and Health (NSDUH) provides an opportunity to conduct a cross-sectional analysis of the changes over time in the prevalence of substance use and perceptions of risk. Although crosssectional analysis cannot confirm that increases in substance use are a direct result of decreases in perceptions of risk, this report examines how rates of substance use and perceived risk vary over time and in relation to each other. Understanding the relationship between risk perception and substance use during adolescence may help to better target health promotion messages and increase the effectiveness of prevention and intervention programs.
Uso de SCRATCH en el aprendizaje de Programación en Educación Superior

In recent years, the term computational thinking and Scratch programming language have broken into the teaching stage, primarily at the level of elementary and high school education. However, there are no studies that support the use of Scratch language at a higher level, thus the aim of this research was the verification of the development of computational thinking among the students of the First Semester of the Computer Science Degree of the Central University of Ecuador based on the eight dimensions of computational thinking that are: identification of patterns, use of instructions, variables, sequence, operators, reuse, abstraction, operation and error detection. For this purpose, a quasiexperimental design with pre-test-post-test and intact groups was applied, with a quantitative, field approach with documentary support and explanatory level. Subsequently, the SPSS tool was used for the statistical analyzes, both for the calculation of the measures of central tendency and the standard deviation, as well as in the verification of the hypotheses by means of T tests and in the elaboration of statistical figures. The results obtained evidenced a greater development in the levels of computational thinking with the students of the First Semester of the Computer Science Career of the Central University of Ecuador who used Scratch.
Interventional electrophysiology in advanced heart disease atrial fibrillation and heart failure

-4! Table-of-contents-. -5! List-of-figures-. -12! List-of-tables-. -14! 1! Introduction-. -15! 1.1! Background-. -15! 1.2! Atrial-fibrillation-in-heart-failure-. -16! 1.2. 1! Impact! on! morbidity! and! mortality! 17! 1.2. 2! Atrial! fibrillation! promoting! heart! failure! 19! 1.2. 3! Heart! failure! promoting! atrial! fibrillation! 20! 1.3! Management-of-atrial-fibrillation-. -23! 1.3. 1! Atrial! fibrillation! in! context! 23! 1.3. 2! Medical! therapy! 25! 1.3. 3! NonBmedical! therapy! 31! 1.3. 4! Rate! versus! rhythm! control! 34! 1.4! Interventional-Electrophysiology-. -42! 1.4. 1! Historical! Background! 42! 1.4. 2! Radiofrequency! Ablation! 42! 1.4. 3! Development! of! AF! ablation! 43! 1.4. 4! Pulmonary! Vein! Isolation! 47!
Joint Management of CPU and NVDIMM for Breaking Down the Great Memory Wall

To provide larger memory space with lower costs, NVDIMM is a production-ready device. However, directly placing NVDIMM as the main memory would seriously degrade the system performance because of the “great memory wall” caused by the fact that in NVDIMM, the slow memory (e.g., flash memory) is several orders of magnitude slower than the fast memory (e.g., DRAM). In this article, we present a joint management framework of host/CPU and NVDIMM to break down the great memory wall by bridging the process information gap between host/CPU and NVDIMM. In this framework, a page semantic-aware strategy is proposed to precisely predict, mark, and relocate data or memory pages to the fast memory in advance by exploiting the process access patterns, so that the frequency of the slow memory accesses can be further reduced. The proposed framework with the proposed strategy was evaluated with several well-known benchmarks and the results are encouraging.
Impact of Janani Suraksha Yojana on institutional delivery rate, incidence of rupture uterus and feto-maternal outcome related to uterine rupture

Background: To study the impact of janani suraksha yojana (JSY) on institutional delivery rate, incidence of rupture uterus in pregnant women, maternal and fetal mortality rate related to rupture uterus. Methods: 33 cases of rupture uterus which occurred before -implementation of JSY in our hospital in one year duration i.e Jan 2007-Dec 2007 (group 1) were studied and compared with 41 cases which occurred after implentation of JSY in one year i.e. July 2014-Jun 2015 (group 2). This is a retrospective observational study. Information were collected regarding number of institutional deliveries, incidence of rupture uterus ,previous history of unscarred and scarred uterus, maternal and fetal mortality rate related to uterine rupture. Results: there was 125% proportional increase in the institutional deliveries, significant decrease in the incidence of rupture uterus (Z=2.5963, P<0.05) and maternal mortatility (Chisquare at 1 df=4.326, P<0.05) after implementation of JSY. Conclusions: JSY is working excellently and need to be extended until we achieve the goal of 100% institutional deliveries and 0 % maternal mortality rate related to rupture uterus.
Innovative Approaches To Identify Regulators Of Liver Regeneration

The mammalian liver possesses a remarkable ability to regenerate after injury to prevent immediate organ failure. However, amid a rising global burden of liver disease, the only curative treatment for patients with end-stage liver disease is transplantation. Elucidating the mechanisms underlying tissue repair and regrowth will enable identification of therapeutic targets to stimulate native liver regeneration, thereby circumventing the great paucity of available transplant organs. Here, utilizing the Fah-/mouse model of liver repopulation, I applied transcriptomic and epigenomic techniques to investigate the changes occurring as hepatocytes restore organ mass following toxic injury. By labeling ribosomal or nuclear envelope proteins, I performed the first extensive characterization of gene expression and chromatin landscape changes specifically in repopulating hepatocytes in response to injury. Transcriptomic analysis showed that repopulating hepatocytes highly upregulate Slc7a11, a gene that encodes the cystine/glutamate antiporter. I demonstrated that ectopic Slc7a11 expression promotes liver regeneration and Slc7a11 mutation inhibits hepatocyte replication. Integrative bioinformatics analyses of chromatin accessibility revealed dynamic changes at promoters and liver-enriched enhancer regions that correlate with the activation of proliferation-associated genes and the repression of transcripts expressed in mature, quiescent hepatocytes. Furthermore, changes in chromatin accessibility and gene expression are associated with increased promoter binding of CCCTC-binding factor (CTCF) and decreased enhancer occupancy of hepatocyte nuclear factor 4α (HNF4α). In summary, my thesis work identifies Slc7a11 as a potential driver of liver regeneration, and provides insights into the complex crosstalk between chromatin accessibility and transcription factor occupancy to regulate gene expression in repopulating hepatocytes. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Pharmacology First Advisor Klaus H. Kaestner
Ocena poziomu wiedzy żywieniowej za pomocą kwestionariusza komPAN pacjentów po ostrym zespole wieńcowym hospitalizowanych na oddziale kardiologii inwazyjnej. Doniesienie wstępne

Introduction. Cardiovascular diseases are the major cause of mortality in Poland. Thus, both primary and secondary prevention should include lifestyle modification, including proper nutrition. The aim of the study was to examine dietary habits and nutritional beliefs for the purpose of evaluating the nutrition knowledge of cardiac patients after an acute coronary syndrome [ACS; non-ST-segment myocardial infarction (NSTEMI) and ST-segment myocardial infarction (STEMI)] undergoing invasive treatment. Material and methods. The study included 100 patients, including 35 women and 65 men aged 53.43 ± 10.11 years [mean ± standard deviation (SD)], admitted urgently due to ACS to the 2nd Department of Cardiology. The study used part C of the questionnaire: “Nutrition Beliefs” that consisted of 25 statements assessing nutrition knowledge. For each correct answer (“True” or “False”), 1 point was assigned, and for an incorrect answer or “Hard to say”, 0 points were assigned. Then, the points were added up. Results. It was found that only 20.8% (N = 21) of subjects followed dietary recommendations as advised by a physician. The majority of respondents were diagnosed with an excessive body mass: obesity in 35.4% (N = 35) of subjects, and overweight in 38.4% (N = 38) of subjects. Nutritional self-assessment was reported to be at a good level in 71.3% of patients (N = 72). However, the actual nutrition knowledge was found to be at a good level in only 6.9% (N = 7) of subjects. Conclusion . Patient nutrition knowledge as assessed using the komPAN questionnaire was found to be mostly at a satisfactory level, despite high self-assessment res ults provided by the respondents. There is a great need for regular nutrition education.
Morphometric Analysis of the Nira River Basin in Maharashtra State, India using Geographical Information System

Morphometric analysis using remote sensing data and geo-spatial technique has emerged as a powerful tool in recent years. Remote sensing has the ability of obtaining synoptic view of the large area at one time and very useful in analysing the drainage morphometry. Morphometry is the measurement and mathematical analysis of the configuration of the earth’s surface, shape and dimension of its landforms (Clarke, 1966). This analysis can be achieved through measurement of linear, aerial and relief aspects of the basin and slope contribution (Nag and Chakraborty, 2003).
Percepções do consumidor da qualidade do serviço varejista de rua

O estudo avaliou a percepcao de qualidade no atendimento do varejo tradicional de rua em Juiz de Fora, Minas Gerais. Utilizou-se uma adaptacao local a escala SERVQUAL identificando quais atributos sao valorizados pelo consumidor em relacao de qualidade percebida deste servico. Constatou-se nas 702 entrevistas com os consumidores, coerentemente com estudos que tratam de aspectos culturais dos mineiros, como sendo a empatia a dimensao mais relevante, seguida da dimensao tangibilidade. Tal achado e compativel com as pesquisas que apontam o traco cultural tipico do mineiro: a desconfianca. Os resultados permitem que os gestores do varejo local alinhem os esforcos de treinamento da esquipe de vendas na direcao das expectativas dos consumidores. O estudo amplia a discussao sobre a relacao entre os aspectos culturais e a percepcao de qualidade no atendimento e instiga a area academica para novas propostas de pesquisa na area de varejo de rua.
A phase I study of a novel taxane, TL310, orally administered every week in patients (pts) with advanced solid tumors

2544 Background: TL310 is a novel, oral taxane with potent pre-clinical activity in taxane-resistant model systems. This is the first study to evaluate the safety, tolerability and pharmacokinetics (PK) of TL310 in pts with advanced refractory solid tumors. Methods: Pts with adequate hematologic, renal, and liver function received TL310 administered orally on days 1, 8 and 15 of a 28-day cycle. Pts were continuously assessed for safety and dose-limiting toxicity (DLT) was based on first cycle toxicity only. A rapid dose escalation schedule was used (1 pt per dose level until ≥ grade 2 toxicity then 3–6 patients per cohort). The maximum tolerated dose (MTD) was defined as the dose level below that at which ≥ 2 of 3–6 pts experienced DLT. PK sampling was performed on days 1, 2, 3–4, 8, 15, 16, 17–18, 22 of cycle one. Serial imaging with CT was performed every 8 weeks to assess response. Results: 18 patients [M=11, F=7], ECOG PS ≤ 2 were treated with doses of 5 (1 pt), 10 (1pt), 20 (1pt), 40(2pts), 80 (5pts).
Updated survival and biomarker analyses of a randomized phase II study of atezolizumab vs. docetaxel in 2L/3L NSCLC (POPLAR)

9028Background: Atezolizumab (atezo, MPDL3280A), a humanized engineered mAb, is the first anti-PD-L1 agent to show improved OS vs docetaxel (doc) in NSCLC. These results correlate with PD-L1 expres.
Origin of Triassic mafic magmatism in the North Qiangtang terrane, central Tibetan Plateau: implications for the development of a continental back-arc basin

This paper presents a comprehensive study of geochronology, in situ clinopyroxene mineralogy, geochemistry and isotope geology for the Triassic mafic magmatism of the central Tibetan Plateau. Moreover, the results are used to understand the development of a continental back-arc basin and the generation of back-arc basin magmatism. Zircon U–Pb isotope analyses indicate that these rocks were formed during the Middle Triassic (c. 231 Ma). Both the mafic rocks and the trapped melt calculated by the clinopyroxene/melt partition coefficient (Dcpx/melt) exhibit distinct enrichments in light rare earth elements (LREE) and Th with pronounced depletions in Nb and Ta, which are similar to the geochemical composition of typical continental back-arc basin basalts. Geochemical features and isotopic variations indicate that the mafic melts originated from a depleted mantle modified by c. 10% crustal components. The ratios of Zn/Fet and REE further suggest a spinel-bearing peridotite source. Considering other regional geological data, we argue that the origin of Triassic mafic magmatism should be attributed to the extension of a continental back-arc basin. Slab rollback and mantle plume activity played vital roles in the formation and development of a continental back-arc basin in the central part of the Tibetan Plateau.
Exosomes from adipose-derived stem cells promote chondrogenesis and suppress inflammation by upregulating miR-145 and miR-221

Osteoarthritis (OA) is one of the most prevalent joint disorders globally. Patients suffering from OA are often obese and adiposity is linked to chronic inflammation. In the present study, the potential of using exosomes isolated from adipose-derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient-derived primary cells. First, it was tested whether patient-derived ADSCs could differentiate into chondrogenic and osteogenic lineages. The ADSCs were then used as a source of exosomes. It was found that exosomes isolated from ADSCs, when co-cultured with activated synovial fibroblasts, downregulated the expression of pro-inflammatory markers interleukin (IL)-6, NF-κB and tumor necrosis factor-α, while they upregulated the expression of the anti-inflammatory cytokine IL-10; without exosomes, the opposite observations were made. In addition, inflammation-inflicted oxidative stress was induced in vitro by stimulating chondrocytes with H2O2. Treatment with exosomes protected articular chondrocytes from H2O2-induced apoptosis. Furthermore, exosome treatment promoted chondrogenesis in periosteal cells and increased chondrogenic markers, including Collagen type II and β-catenin; inhibition of Wnt/β-catenin, using the antagonist ICG-001, prevented exosome-induced chondrogenesis. Periosteal cells treated with exosomes exhibited higher levels of microRNA (miR)-145 and miR-221. The upregulation of miR-145 and miR-221 was associated with the enhanced proliferation of periosteal cells and chondrogenic potential, respectively. The present study provided evidence in support for the use of patient-derived exosomes, produced from ADSCs, for potential chondrogenic regeneration and subsequent amelioration of osteoarthritis.
Nonlinear Control of Bilateral Teleoperators Interacting Non-passive Termination Forces

: In this paper, an interconnection and damping assignment passivity based controller is developed for nonlinear bilateral teleoperation system. The aim is to track the position and force in the teleoperation system in the presence of non-passive external interactions and asymmetric variable time-delay in the communication channel. For this end, a nonlinear control law is designed based on the notion of time-delay Port-Hamiltonian systems for unforced teleoperator and the Lyapunov-Krasovskii theorem. Sufficient synthesis conditions are derived in terms of linear matrix inequalities to tune the parameters of controller. Then, by Lyapunov redesign scheme, an auxiliary controller is developed to assure the stable position tracking in the presence of non-passive operator and/or environment. The main contribution of the proposed method is that the stability and position tracking of system is attained via a fixed-structure controller in the presence of non-passive interaction forces without need to their dynamical models and force sensor. Since the proposed design conditions include the upper bounds of the varying time-delays and their rates; they are less conservative than some rival methods in literature. Finally, transparency of the proposed scheme is proved. Simulation results on a 2-degree of freedom teleoperation system are compared to rival methods to demonstrate the merits of the proposed strategy.
Fast Food Addiction: A Major Public Health Issue

Fast food/Junk food is designed to be tasty, comforting and convenient. Unfortunately, whilst these foods contain lots of calories, they often have far lower levels of fiber, water and minerals as compared to natural foods. Packaged food and snacks are also created specifically so that we get enough texture and taste from each bite to tantalize our taste buds; but not enough to make us feel full. It’s evident that fast food feels good to eat and tempts us in many different situations. Fast food first popularized in the 1970s in the United States, which has today the largest fast food industry in the world. As taste, time considerations, convenience, and cost are major factors that contribute to an adolescent's or young adult's food choices, fast food restaurants serve as popular sites for their meals eaten outside the home. Current approaches suggest that fast food restaurants should be required to clarify nutrition information such as energy and fat content on their menu boards and on product packaging. This is important to help the consumer to make better food choices before purchasing. An adequate, nutritious, and balanced diet is essential to maintain health for one's lifetime. To achieve this healthy diet, fast food consumption should be limited.
Studying the physical behavior of human mesenchymal stem cells on the surface of hydroxyapatite after adding graphene as a reinforcement

Introduction: For cell culture assays, different cells have been used so far, including Mouse osteoblast cells (MC3T3-E1), hFOB cells, fibroblast cell, Osteoblast-like MG63 cells, Human osteoblast cells (HFOB 1.19 SV40 transfected osteoblasts), Blood mononuclear cell (PBMC), mesenchymal stem cells (MSCs). Objective: In this study, the effect of graphene sheets on the physical behavior of stem cells was investigated. Material and Methods: The hydrothermal method and spark plasma sintering were used in this study. The analysis performed in the sample includes X-ray diffraction, Scanning Electron Microscope, Raman spectroscopy, and cell culture. Result: The surface of the samples from the hydrophilic (in pure HA) state is somewhat close to the hydrophobic (in HA/rGO nanocomposites) state. It is clear that the physical behavior of the cells on the surface after graphene addition has changed dramatically. Conclusion: The product of this research (HA/rGO nanostructured composite) has the potential to be used in medical applications.
The application of physics e-handout assisted by PBL model use Edmodo to improve critical thinking skills and ICT literacy of high school students

This study aims to improve students’ critical thinking skills and ICT literacy physics using e-handouts assisted by the PBL model using Edmodo material on the Law of Conservation of Momentum and Collision. This type of research is pre-experimental design with one group pretest-posttest design. This study students who participated were class X MIA 1 and X MIA 3 SMA Negeri 1 Sleman with the same treatment. The sample consisted of two classes, each class totaling 30 students. The sample taken is a cluster random sampling technique. Retrieval of data from the results of the pretest and posttest for critical thinking skills, while observation to determine the ICT literacy of students in both classes. The result is that through e-handout assisted by PBL models using Edmodo students can improve critical thinking skills. The application of e-handout assisted by the PBL model using Edmodo to the ICT literacy of students is good enough.
IVIM : modeling, experimental validation and application to animal models

Cette these porte sur l’etude de la sequence d’imagerie IRM IVIM (« Intravoxel incoherent motion »). Cette sequence permet l’etude des microvaisseaux sanguins tels que les capillaires, arterioles et veinules. Pour etre sensible seulement aux groupes de spins non statiques dans les tissus, des gradients de diffusion sont ajoutes avant et apres l’impulsion 180° d’une sequence d’echo de spin. La composante du signal correspondant aux spins qui diffusent dans le tissu peut etre separee de celle des spins en mouvement dans les vaisseaux sanguins qui est appelee signal IVIM. Ces deux composantes sont ponderees par f IVIM qui represente la fraction volumique du sang a l’interieur du tissu. Le signal IVIM est en general modelise par une fonction mono-exponentielle (ME) caracterisee par un coefficient de pseudo-diffusion D*. Nous proposons un modele IVIM bi-exponentiel forme d’une composante lente caracterisee F slow et D* slow qui correspondrait aux capillaires comme dans le modele ME, et d’une composante rapide caracterisee par F fast et D* fast qui correspondrait a des vaisseaux plus gros comme des arterioles et veinules. Ce modele a ete valide experimentalement et des informations supplementaires ont ete obtenues en comparant les signaux experimentaux avec un dictionnaire de signaux IVIM simules numeriquement. L’influence de la sequence d’impulsions, du temps de repetition et du temps d’encodage de diffusion a egalement ete etudiee. Enfin, la sequence IVIM a ete appliquee a l’etude d’un modele animal de la maladie d’Alzheimer.
www.palliativecareglasgow.info: Developing Online Palliative Care Information

The Glasgow Palliative Care Information Network provides an online source of information about palliative care and palliative care services to patients, their families and professionals, particularly generalists. The information for patients and carers aims to clarify what palliative care is and how such services are accessed. The section for professionals includes guidelines, protocols, links and resources which can be used to support their practice in both hospital and community settings. It is also planned to place public access terminals in relevant locations across the city to encourage access to the information available online and by so doing to improve awareness of palliative care and how it is delivered. In addition the network will offer internet access to a group of patients and assess the effect of the web based information on anxiety levels when compared to more traditional media.