Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Obsessive-Compulsive Personality Disorder on the Suicidal Risk of Patients with Mood Disorders

Background: The association of mood disorders with personality disorder is frequent and relevant in terms of clinical and therapeutic aspects. Personality disorders may modify the phenomenology of axis I psychiatric disorders, generating atypical clinical features, uncommon behavior or unusual patient attitudes. Sampling and Methods: The paper describes the atypical symptoms of 7 patients affected by mood disorder associated with obsessive-compulsive personality disorder (OCPD) who made a near-lethal suicide attempt and were admitted to a psychiatric intensive care unit. Results and Conclusions: The presence of OCPD associated with mood disorders may increase the risk of misdiagnosis, render some life events more stressful than usual for patients and increase the severity of the suicide attempt.
Dissecting impulsivity and its relationships to drug addictions

Addictions are often characterized as forms of impulsive behavior. That said, it is often noted that impulsivity is a multidimensional construct, spanning several psychological domains. This review describes the relationship between varieties of impulsivity and addiction‐related behaviors, the nature of the causal relationship between the two, and the underlying neurobiological mechanisms that promote impulsive behaviors. We conclude that the available data strongly support the notion that impulsivity is both a risk factor for, and a consequence of, drug and alcohol consumption. While the evidence indicating that subtypes of impulsive behavior are uniquely informative—either biologically or with respect to their relationships to addictions—is convincing, multiple lines of study link distinct subtypes of impulsivity to low dopamine D2 receptor function and perturbed serotonergic transmission, revealing shared mechanisms between the subtypes. Therefore, a common biological framework involving monoaminergic transmitters in key frontostriatal circuits may link multiple forms of impulsivity to drug self‐administration and addiction‐related behaviors. Further dissection of these relationships is needed before the next phase of genetic and genomic discovery will be able to reveal the biological sources of the vulnerability for addiction indexed by impulsivity.
Sperm Depletion and Mating Behavior in the Parasitoid Wasp Spalangia Cameroni (Hymenoptera: Pteromalidae)

Mating behavior was examined in the parasitoid wasp Spalangia cameroni. Males attempted copulation with both virgins and already mated females. Males attempted copulation regardless of whether they still had sperm. Already mated females rejected attempts to mate again but virgin females would mate with males regardless of whether or not they had sperm left. Males mated with 12-52 females before exhausting their sperm supplies. Males that had mated only once daily exhausted their sperm supplies in their late thirties (days old), if ever; and males that had mated four times daily exhausted their's at 7-13 days. Males produced as many as 438 daughters from their first four matings. Fifty-seven percent (17 of 30) of females that had mated with virgin males exhibited a decrease in proportion of daughters with age, presumably as a result of sperm depletion. Whether or not a female depleted her sperm supplies was not related to her size or the total number of daughters that she had produced.
Ex vivo investigation of the use of hydrothermal energy to induce chondrocyte necrosis in articular cartilage of the metacarpophalangeal and metatarsophalangeal joints of horses.

OBJECTIVE To evaluate the use of hydrothermal ablation of articular cartilage for arthrodesis in horses through investigation of the effects of joint lavage with physiologic saline (0.9% NaCI) solution (80 degrees C) for various treatment times on chondrocyte viability in the articular cartilage of the metacarpophalangeal and metatarsophalangeal joints of cadaveric horse limbs. Sample Population-7 pairs of metacarpophalangeal and 8 pairs of metatarsophalangeal joints from 8 Thoroughbreds. PROCEDURE The horses were euthanatized for reasons unrelated to musculoskeletal disease. On a random basis, 1 joint of each pair underwent intra-articular lavage for 5, 10, or 15 minutes with heated saline solution (80 degrees C); the other joint underwent sham treatment of similar duration with saline solution at 22 degrees C (control). Cartilage samples from the distal articular surface of metacarpus III (or metatarsus III), the proximal surface of the proximal phalanx, and the lateral and medial proximal sesamoid bones were assessed for chondrocyte viability via confocal microscopy and viability staining following enzymatic digestion. RESULTS Compared with the control joints, findings of both viability assays indicated that the percentage of sites containing viable chondrocytes in heat-treated joints was decreased. Treatment hazard ratios of 0.048 (confocal microscopy) and 0.2 (digestion assay) were estimated. Histologically, periarticular soft tissues had minimal detrimental effects after heat treatment. CONCLUSIONS AND CLINICAL RELEVANCE Ex vivo intra-articular lavage with saline solution at 80 degrees C resulted in the death of almost all articular chondrocytes in the joint. This technique may be a satisfactory method for extensive cartilage ablation when performing arthrodesis by minimally invasive techniques.
Intramucosal Distribution of WNT Signaling Components in Human Esophagus

Goals To determine expression and localization of Wnt signaling molecules across the esophageal mucosal thickness. Background The molecular mechanisms governing the biology and pathobiology of esophageal squamous mucosa in health and disease are not completely understood. Earlier genome-wide expression study of normal-looking esophageal squamous mucosa has shown differential expression of the Wingless-type MMTV integration site family (Wnt) modulators Dickkopf (Dkk) homologs among healthy individuals and patients with reflux esophagitis and Barrett metaplasia suggesting that the Wnt pathway may be involved in esophageal mucosal biology. Study Seven full-thickness human donor esophagi were cryosectioned for immunohistochemical analysis, and lamina propria (LP), basal (BC), intermediate (IC), and superficial (SC) cells were also dissected by laser-capture microdissection for real-time polymerase chain reaction. Results Wnt1, 2b, and 3a were expressed primarily in BC, Wnt3, and 5b in LP, and Wnt5a in IC. Frizzled 1, low-density lipoprotein receptor-related protein 6, secreted frizzled-related protein 1, T-cell–specific transcription factor 3, and dishevelled 3 were expressed highest in LP decreasing precipitously medially toward SC. Dkk1 predominantly expressed in SC was more than 100-folds greater than other layers (P<0.001). Dkk4 was expressed primarily in SC but Dkk3 was opposite with greatest expression in LP. Immunohistochemical analysis showed Wnt1 and 3a in BC, Wnt5a in IC and SC, Dkk1 predominantly in SC, Dkk4 in SC and IC, and Dkk3 and SFRP1 in LP and BC. Conclusions Signaling components are expressed in a differential manner within the different layers of esophageal squamous mucosa suggesting their involvement in mucosal cell biology locally.
A Real-Time FHD Learning-Based Super-Resolution System Without a Frame Buffer

This brief presents a real-time learning-based super-resolution (SR) system without a frame buffer. The system running on an Altera Stratix IV field programmable gate array can achieve output resolution of 1920 <inline-formula> <tex-math notation="LaTeX">$\times $ </tex-math></inline-formula> 1080 (FHD) at 60 fps. The proposed architecture performs an anchored neighborhood regression algorithm that generates a high-resolution image from a low-resolution image input using only numbers of line buffers. This real-time system without a frame buffer makes it possible to integrate SR operation into image sensors or display drivers carrying out computational photography and display.
Correlation between osteosarcoma and the expression of WWOX and p53

The objective of this study was to analyze the effect of the expression of WWOX and p53 on the growth of MG-63 osteosarcoma cells and to explore the correlation between osteosarcoma and the expression of WWOX and p53. WWOX and p53-overexpressing MG-63 osteosarcoma cell lines were established by transfection and named the MW and MP cell lines, respectively. Untransfected MG-63 cells (blank control) were used as control. Quantitative polymerase chain reaction (qPCR) and western blot analysis were used to detect the expression of WWOX and wild-type p53 mRNA and protein, respectively. The effects of WWOX and p53 (wild-type) on the activity of MG-63 cells were determined by MTT assay and flow cytometry. The expression of mutant p53 protein in 65 cases of osteosarcoma was detected by immunohistochemistry to analyze the correlation between p53 and the development of osteosarcoma. qPCR showed that WWOX and p53 mRNA was overexpressed in MW and MP cells, respectively. Western blot analysis showed that the levels of WWOX and p53 protein in MW and MP cells were higher than in the blank control group. MTT assay showed that the cell proliferation ability of MW and MP cells was significantly lower than in the blank control group. Flow cytometry showed that 78.49% of MW and 66.76% of MP cells were arrested in the G0/G1 phase. Immunohistochemistry showed that mutant p53 was highly expressed in osteosarcoma, with a positive expression rate of 47.7%. The expression rate was positively correlated with the pathological grade of cancer. In conclusion, WWOX can affect the cell cycle of MG-63 osteosarcoma cells to inhibit cell proliferation, which provides new insights into gene therapy for osteosarcoma. The two types of the p53 gene have different functions in the development of osteosarcoma. Wild-type p53 acts as a tumor suppressor, while mutant p53, which is overexpressed in malignant osteosarcoma, has a carcinogenic effect associated with the degree of osteosarcoma.
Aspectos epidemiológicos, clínicos y de laboratorio de la candidemia en el siglo XXI

Candida spp. es responsable de alrededor del 80% de todas las infecciones fungicas nosocomiales. Ocupa el cuarto lugar entre los microorganismos causantes de infeccion en el torrente circulatorio en EEUU y el septimo en Europa. Existen numerosos estudios epidemiologicos sobre candidemia, efectuados en escenarios muy diversos, durante cortos periodos de tiempo y elaborados con distintos disenos, que coinciden en senalar que se ha producido un incremento significativo de las candidemias en las ultimas dos decadas. La magnitud del incremento descrito podria obedecer a diferentes motivos. No se dispone de informacion que proporcione una mayor perspectiva en el tiempo que incluya un importante numero de candidemias en pacientes no seleccionados, diagnosticados y tratados por un mismo equipo de profesionales, de acuerdo con una misma metodologia que nos pueda proporcionar una interpretacion mas realista sobre los cambios producidos. La candidemia es una infeccion con una mortalidad que oscila entre el 29-76%, pudiendo llegar la mortalidad relacionada con la infeccion hasta el 49%. La evolucion clinica depende no solo de la adecuacion del tratamiento sino de la gravedad de las enfermedades de base y del estado clinico del paciente. Se ha senalado que los nuevos metodos diagnosticos y terapeuticos apenas han modificado la mortalidad de forma relevante. Es necesario conocer si se ha producido algun cambio en los factores de riesgo de mortalidad de acuerdo a datos clinicos recientes y analizar si las diferencias en el abordaje de las candidemias en distintos periodos de tiempo han tenido alguna repercusion en el pronostico. Las recomendaciones sobre el manejo de las candidemias en pacientes con cateter vascular incluyen la retirada del mismo siempre que sea posible. Aunque existen resultados contradictorios, hay publicaciones que demuestran que la retirada precoz tiene importancia pronostica, no solo en las candidemias por cateter sino tambien en las primarias aunque no es infrecuente que se incluyan como candidemias primarias a infecciones que en realidad estan producidas por cateter pero no se dispone de cultivo del mismo.
Fast smoothing technique with edge preservation for single image dehazing

In the single-image dehazing problem, it is critical that the transmission is accurately estimated. However, the extracted transmission in the dark channel model cannot effectively deal with the edge and the sky area because of the poor applicability of the dark channel prior to these areas. This study aims to solve that problem by proposing a novel variational model (VM) to optimise the transmission. This VM introduces a smoothness term and a gradient-preserving term to mitigate the false edge and the distorted sky area in the recovered image. Further, a fast algorithm to solve the VM is proposed on the basis of the additional operator splitting algorithm. This algorithm is an effective linear time algorithm and has excellent performance on optimising the transmission. The average running time of the algorithm shows an improvement of over 20 times that of the guided image filtering in these experiments. Experimental results also show that the proposed algorithm is both effective and efficient for optimising the transmission.
Probabilistic Versus Deterministic Data Matching : Making an Accurate Decision

Consider the following scenario: One night paramedics wheel a man named John K. Spenser into a hospital emergency room where admitting staff work to determine his medical history. Because the facility had not invested in an effective identity matching solution, a query of the hospital database and area medical centers does not correctly identify the patient as John K. Spencer (different spelling). To further complicate matters, because there wasn't a match, the medical staff was not aware of an important medical detail that could mean the difference between life and death: Mr. Spencer has a history of anaphylaxis, a potentially fatal allergic reaction to Penicillin and clot-busting drugs used after heart attacks.
Concerted antigen presentation by dendritic cells and B cells is necessary for optimal CD4 T‐cell immunity in vivo

The relative contributions of different types of antigen presenting cells to T‐cell activation, expansion and induction of effector functions are still not fully understood. In order to evaluate the roles of dendritic versus B cells during these phases of a CD4 T‐cell response in vivo, we adoptively transferred major histocompatibility complex class II restricted, T‐cell receptor‐transgenic CD4+ T cells into transgenic mice expressing selectively the T‐cell restricting class II molecules on either dendritic cells, B cells or both. Upon immunization with peptide antigen, we observed that dendritic cells were sufficient to induce activation, expansion, interleukin‐2 production and germinal centre migration of antigen‐specific T cells, independently of other antigen‐presenting cells. In contrast, neither resting nor activated B cells had similar antigen‐presenting capacities in vivo. However, in double transgenic mice where both B cells and dendritic cells were capable of presenting antigen, T cells showed increased proliferation, expansion and cytokine production in vivo. Moreover, higher antigen‐specific CD4 T‐cell numbers accumulated in germinal centres. Our data demonstrate that dendritic cells are sufficient to activate naive CD4 T cells in vivo, but B cells subsequently can enhance CD4 T‐cell expansion further.
Physical-Layer Secrecy Performance in Finite Blocklength Case

For physical-layer secrecy performance, existing studies only focus on coding schemes that can achieve the secrecy capacity. However, finite blocklength penalty could be fatal for security of private message. In this paper, we explore the impact of finite blocklength on secrecy for the wiretap channel model. We propose secrecy performance matrices for finite blocklength analysis and provide analytical expressions to evaluate the secrecy performance. We demonstrate trade-off between secrecy and reliability, and also provide an upper bound of secret information rate in finite blocklength case. The results are also applied to indicate asymptotic performance.
Long-term temporal variation in the organization of an ant-plant network.

BACKGROUND AND AIMS Functional groups of species interact and coevolve in space and time, forming complex networks of interacting species. A long-term study of temporal variation of an ant-plant network is presented with the aims of: (1) depicting its structural changes over a 20-year period; (2) detailing temporal variation in network topology, as revealed by nestedness and modularity analysis and other parameters (i.e. connectance, niche overlap); and (3) identifying long-term turnover in taxonomic structure (i.e. switches in ant resource use or plant visitor assemblages according to taxa). METHODS Fieldwork was carried out at La Mancha, Mexico, and ant-plant interactions were observed between 1989 and 1991, between 1998 and 2000, and between May 2010 and 2011. Occurrences of ants on extrafloral nectaries (EFNs) were recorded. The resulting ant-plant networks were constructed from qualitative presence-absence data determined by a species-species matrix defined by the frequency of occurrence of each pairwise ant-plant interaction. KEY RESULTS Network variation across time was stable and a persistent nested structure may have contributed to the maintenance of resilient and species-rich communities. Modularity was lower than expected, especially in the most recent networks, indicating that the community exhibited high overlap among interacting species (e.g. few species were hubs in the more recent network, being partly responsible for the nested pattern). Structurally, the connections created among modules by super-generalists gave cohesion to subsets of species that otherwise would remain unconnected. This may have allowed an increasing cascade-effect of evolutionary events among modules. Mutualistic ant-plant interactions were structured 20 years ago mainly by the subdominant nectarivorous ant species Camponotus planatus and Crematogaster brevispinosa, which monopolized the best extrafloral nectar resources and out-competed other species with broader feeding habits. Through time, these ants, which are still present, lost their position as network hubs and diminished in their importance in structuring the network; simultaneously, plants gained in importance. CONCLUSIONS The long-term network analysis reveals a decrease in attended plant species richness, a notable increase in plant species participation from 1990 to 2010 (sustained by less plant taxonomic similarity in the older 1990 network), an increase in the number of ant species and a diminishing dominance of super-generalist ants. The structure of the community has remained highly nested and connected with low modularity, suggesting overall a more participative, homogeneous, cohesive interaction network. Although previous studies have suggested that interactions between ants and EFN-bearing plants are susceptible to seasonality, abiotic factors and perturbation, this cohesive structure appears to be the key for biodiversity and community maintenance.
Competências de Estudo dos Estudantes Universitários: Estudo comparativo entre uma universidade portuguesa e brasileira

Para se compreender as competencias de estudo e autorregulacao no ensino superior, ha que se colocar o estudante como centro do seu processo de aprendizagem. Neste estudo analisou-se a relacao entre o perfil de competencias de estudos, dos estudantes de universidades de dois paises (Brasil e Portugal). Trata-se de um estudo comparativo, transversal, de abordagem quantitativa, com 1240 estudantes universitarios, aos quais foi aplicado um inquerito por questionario. O tratamento de dados foi efetuado com recurso ao SPSS.
Is pre-psychotic intervention of schizophrenia realistic ?

Schizophrenia is a serious disorder that often affects young people in their early twenties. The outcome is often poor, associated costs and burdens are extensive. Almost 15% of schizophrenics end up with frequent admission and require long-term residential care (1). Recently, the idea of early detection and intervention has been launched as a new and promising approach. The starting point for consideration regarding early intervention strategies is the observation that most patients who develop schizophrenia have had a period with non-specific, non-psychotic prodormal symptoms before the onset of psychosis (2,3). The prodormal period has been reported to last, on average, 1 – 2 years. Another finding across studies in that the period from onset of a manifest psychosis to onset of adequate treatment (duration of untreated psychosis DUP) is long. The mean duration of DUP is 1-2 years with a median of approximately 26 weeks. The majority of studies show a statistically significant correlation between long DUP and poor outcome (4,5), although others have not found the correlation (6,7).
A Metric for Music Notation Transcription Accuracy

Automatic music transcription aims at transcribing musical performances into music notation. However, most existing transcription systems only focus on parametric transcription, i.e., they output a symbolic representation in absolute terms, showing frequency and absolute time (e.g., a pianoroll representation), but not in musical terms, with spelling distinctions (e.g., A[ versus G]) and quantized meter. Recent attempts at producing full music notation output have been hindered by the lack of an objective metric to measure the adherence of the results to the ground truth music score, and had to rely on time-consuming human evaluation by music theorists. In this paper, we propose an edit distance, similar to the Levenshtein Distance used for measuring the difference between two sequences, typically strings of characters. The metric treats a music score as a sequence of sets of musical objects, ordered by their onsets. The metric reports the differences between two music scores based on twelve aspects: barlines, clefs, key signatures, time signatures, notes, note spelling, note durations, stem directions, groupings, rests, rest duration, and staff assignment. We also apply a linear regression model to the metric in order to predict human evaluations on a dataset of short music excerpts automatically transcribed into music notation.
Advanced phenotyping in hypersensitivity drug reactions to NSAIDs

Non‐steroidal anti‐inflammatory drugs (NSAIDs) are the medications most frequently involved in hypersensitivity drug reactions. Because NSAIDs are prescribed for many conditions, this is a world‐wide problem affecting patients of all ages. Various hypersensitivity reactions have been reported, mainly affecting the skin and/or the respiratory airways. The most frequent of these is acute urticaria, which can be induced by several different NSAIDs. Both specific and non‐specific immunological pathways have been proposed as underlying mechanisms. This review presents the clinical phenotypes and the drugs involved in NSAID hypersensitivity. Five major clinical syndromes can be distinguished: aspirin‐exacerbated respiratory disease (AERD), aspirin‐exacerbated cutaneous disease (AECD), multiple NSAID‐induced urticaria/angioedema (MNSAID‐UA), single NSAID‐IgE reactions and single NSAID T cell responses. However, further classification is possible within these five major entities, by detailed descriptions of the clinical characteristics enabling more phenotypes to be defined. This detailed differentiation now seems required in order to undertake appropriate pharmacogenetic studies.