Miracle-dz/UniFAR-FTUs huggingface dataset:
Managing resistance to agrochemicals : from fundamental research to practical strategies

Understanding and Combating Agrochemical Resistance: A Chemist's Perspective on an Interdisciplinary Challenge Overview of Insecticide Resistance Resistance Mechanisms to Carbamate and Organophosphate Insecticides Biochemical and Genetic Mechanisms of Insecticide Resistance Characterization and Exploitation of Instability of Spider Mite Resistance to Acaricides Laboratory Evaluation and Empirical Modeling of Resistance-Countering Strategies Targeting Insecticide-Resistant Markets: New Developments in Microbial-Based Products Strategies for Managing Resistance to Insecticides in Heliothis Pests of Cotton Pyrethroid Resistance in Heliothis spp. : Current Monitoring and Management Programs Management of Pesticide Resistance in Arthropod Pests: Research and Policy Issues Antiresistance Strategies Design and Implementation in Practice Sterol Biosynthesis Inhibitors: Model Studies with Respect to Modes of Action and Resistance Resistance to Sterol Biosynthesis-Inhibiting Fungicides: Current Status and Biochemical Basis Biochemical Basis of Resistance to Phenylamide Fungicides Mechanism of Action of N-Phenylcates to Benzimidazole-Resistant Neurospora Strains Binding of Cellular Protein from Venturia nashicola Isolates to Carbendazim: Its Relationship with Sensitivity to N-Phenylcarbamate, N-Phenlformamidozime Compounds, and Rhizoxin Edifinphos Resistance in Pyricularia oryzae and Drechslera oryzae: In Vitro Techniques for Detection and Control Management of Fungicide Resistance by Using Computer Simulation Population Biology and Management of Fungicide Resistance Impact of Fungicide Resistance on Citrus Fruit Decay Control Predicting the Evolution of Fungicide Resistance The Fungicide Resistance Action Committee: An Update on North American Initiatives, Goals, and Strategies Herbicide Resistance in Weeds and Crops: An Overview and Prognosis Fate of Herbicide Resistance Genes in Weeds Structural and Biochemical Characterization of Dinitroanillne-Resin Herbicide Cross-Resistance in Annual Ryegrass (Lolium rigidum Gaud): The Search for a Mechanism Peroxidizing Herbicides: Some Aspects on Tolerance Fitness and Ecological Adaptability of Herbicide-Resistant Biotypes Herbicide Rotations and Mixtures: Effective Strategies to Delay Resistance Herbicide-Resistant Plants Carrying Mutated Acetolactate Synthase Genes Genetic Modification of Crop Responses to Imidazolinone Herbicides
Effecten van kringlooplandbouw op ecosysteemdiensten en milieukwaliteit : een integrale analyse van People, Planet & Profit, effecten op gebiedsniveau, en de potentie voor zelfsturing, met de Noardlike Fryske Wâlden als inspirerend voorbeeld

Kringlooplandbouw is een vorm van landbouw waarbij de nadruk ligt op het gebruik van op het bedrijf aanwezige hulpbronnen en voorraden, en het behalen van voldoende inkomen over langere termijn met het behoud van de kwaliteit van natuurlijke ecosystemen. In Nationaal Landschap ‘Noardlike Fryske Wâlden’ (NFW) wordt in de melkveehouderij een vorm van kringlooplandbouw bedreven die zich onder andere kenmerkt door het voeren van de melkkoeien met een structuurrijk en eiwitarm dieet, minder gebruik van kunstmest, het bovengronds uitrijden van dierlijke mest en de focus op een hogere bodembenutting van stikstof (N) uit dierlijke mest. Bij deze vorm van kringlooplandbouw ligt de focus op levering van ecosysteemdiensten door de bodem, vanuit haar diverse functies. Belangrijke ecosysteemdiensten, waarbij door de bodem een aanzienlijke bijdrage wordt geleverd, zijn de voedsel- en biomassaproductie, de grondwaterkwaliteit, de opslag van koolstof en de regulering van nutrienten. De maatschappelijke doorwerking van kringlooplandbouw is in potentie zeer groot, en de belangstelling vanuit de maatschappij voor deze vorm van landbouw neemt toe.
Diferenciación de aislamientos colombianos de Bacillus sphaericus patógenos y no patógenos para larvas de mosquitos por amplificación azarosa del adn

Se utilizó la técnica de RAPD para estudiar en el ámbito genético aislamientos colombianos de Bacillus sphaericus, de los cuales 19 eran cepas nativas patógenas para larvas del mosquito Culex quinquefasciatus y 37 no patógenas para dichas larvas. Se encontró que las primeras presentaron patrones de amplificación similares con bandas únicas que permitirían diferenciarlas de los aislamientos sin actividad larvicida, como son la de 1.800 pares de bases (pb) con OPA-08 y la de 691pb con OPA-17. En el fenograma se observaron dos grupos independientes con disimilitud mayor al 90%, a uno de los cuales pertenecen de las cepas toxigénicas, que presentaron gran similitud entre sí, y en el otro se encuentran las no patógenas, que es un grupo heterogéneo con similitudes que varían entre 15 y 85%.
Application of a Pair-Breeding Fathead Minnow (Pimephales promelas) Adult Reproduction Bioassay to a Pulp Mill Effluent

A short-term reproductive bioassay was applied to observe performance of pair-breeding fathead minnow (Pimephales promelas) before and after exposure to treated pulp and paper mill effluent. Reproductive performance was assessed for 21 days under controlled laboratory conditions to obtain baseline data of endpoints including cumulative egg production, number of spawning events, hatching success, and occurrence of deformed larvae. Breeding pairs were then exposed to 50 and 100% concentrations of secondary treated effluent for an additional 21 days. A significant reduction in egg production after exposure to both 100 and 50% pulp mill effluent was observed. This was accompanied by an increased appearance of pathological lesions (eosinophilic material) in male gonads as well as increased gonad size (gonadosomatic index). Reduced hatching success and appearance of larval deformities were also observed after exposure to both 50 and 100% pulp mill effluent. The pattern of responses observed may indicate that the reduced reproductive output was due to exposure to endocrine disrupting compounds within the effluent. By using the short-term fathead minnow bioassay, we were able to identify a response pattern to pulp mill effluent that is indicative of exposure to estrogenic and/or androgenic compounds.
Genetic Counseling and Testing for ColorectalCancer in Young Adults: Mini-Review

Colorectal cancer (CRC) has one of the largest proportions of familial cases. Two to 5% of all colon cancers arise in the setting of inherited syndromes, including Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), familial adenomatous polyposis (FAP), attenuated FAP, MUTYH-associated polyposis (MAP), and certain hamartomatous polyposis conditions like Peutz-Jeghers syndrome (PJS) and juvenile polyposis syndrome (JPS). All of these conditions are inherited, autosomal dominant disorders, except MAP, which is autosomal recessive [1]. Although clinical similarities do exist, each has different cancer risks, characteristic clinical features, and separate genetical etiologies. In addition to these syndromes, up to 30 % of colon cancers exhibit increased familial risk, likely related to inheritance. A number of less penetrant, but possibly more frequent susceptibility genes have been identified for this level of inheritance. Determination of predisposing genes allows for accurate risk assessment and more precise screening approaches. Examples include common polymorphisms in genes that regulate metabolism or genes that are regulated by environmental or other genetic factors. Abbreviations: CRC: Colorectal cancer; HNPCC: Nonpolyposis Colorectal Cancer; FAP: Familial Adenomatous Polyposis; MAP: MUTYHAssociated Polyposis; JPS: Juvenile Polyposis Syndrome. ISSN: 2638-6062 DOI: 10.32474/PRJFGS.2018. 01.000109 Peer Rev J Foren & Gen Sci Copyrights@ Ethem U, et al. Citation: Ethem U, Sema Y, Abdullah Y, Ozgul D, Ahmet T, et al. Genetic Counseling and Testing for Colorectal Cancer in Young Adults: MiniReview. Peer Rev J Foren & Gen Sci 1(1)2018. PRJFGS.MS.ID.000109. DOI: 10.32474/PRJFGS.2018. 01.000109 27 they are about 20 to 25 years old to undergo genetic testing. At-risk patients can be offered genetic counseling and testing to determine whether they carry a detectable mutation for such a syndrome. If so, this information provides the clinician with valuable data about the patient’s risk for other cancers, and alerts surgeon about the correct time for surgery.
THE ASSOCIATION OF DYSLIPIDEMIA WITH INTRAPERITONEAL INFLAMMATION AND PERITONEAL DIALYSIS TECHNIQUE SURVIVAL

The aim of the study was to determine the relationship between the dyslipidemia, intraperitoneal inflammation and peritoneal dialysis (PD) survival. Patients and methods. A total of 40patients with end-stage renal disease treated with continuous ambulatory peritoneal dialysis (PD) have been included in a prospective, observational study (average age was 49.3 ± 12.7). All patients were determined the blood lipid spectrum and IL-10, TNF-a, MCP-1 levels in peritoneal dialysis effluent (PDE). PD adequacy indicators evaluated by determining the concentration of urea and creatinine in plasma, urine and dialysate, calculated weekly creatinine clearance (CrCl), dialysis (Kt/ Vd), renal (Kt/ Vr) and total weekly urea clearance (Kt/ V). Results. Dyslipidemia defined as increase of atherogenic lipoprotein fractions and inhibition ofHDL cholesterol was identified in 70% of the PD-patients. LDL cholesterol level and, accordingly, an atherogenic index (AI) were significantly dependent on the duration of PD treatment (R2 = 2.18 ± 0.15 (95% CI 1.87, 2.5), p < 0,0001 and R2 = 2.77 ± 0.27(95% CI 2.2, 3.3), p < 0,0001). The blood levels of total cholesterol, LDL-C and TG in the patients with diabetes were significantly higher compared with the diabetes-free patients (p = 0.007, p = 0.001 andp = 0.02, respectively). Reducing the HDL cholesterol level was associated with high intraperitoneal production of pro-inflammatory mediators TNF-a (r = - 0.53;p = 0.001) and anti-inflammatory IL-10 (r = - 0.783;p <0.0001), whereas hypertriglyceridemia and high VLDL cholesterol are associated with an increase of MCP-1 (r = 0.6;p = 0.0003 and r = 0.55;p = 0.002, respectively). The Cox proportional hazards regression analysis demonstrated the significant effect of VLDL cholesterol, LDL cholesterol and AI on the survival of PD technique survival (x2 = 24.8; p 3.5 (log-rank test: x2 = 19.8, P = 0.001. Conclusions. Our results can be considered dyslipidemia in PD-patients not only as a traditional risk factor for CVD, but also as a predictor of chronic intraperitoneal inflammation and decrease of PD technical survival.
Sediment Resuspension and Deposition on Seagrass Leaves Impedes Internal Plant Aeration and Promotes Phytotoxic H2S Intrusion

HIGHLIGHTS: Sedimentation of fine sediment particles onto seagrass leaves severely hampers the plants' performance in both light and darkness, due to inadequate internal plant aeration and intrusion of phytotoxic H2S. Anthropogenic activities leading to sediment re-suspension can have adverse effects on adjacent seagrass meadows, owing to reduced light availability and the settling of suspended particles onto seagrass leaves potentially impeding gas exchange with the surrounding water. We used microsensors to determine O2 fluxes and diffusive boundary layer (DBL) thickness on leaves of the seagrass Zostera muelleri with and without fine sediment particles, and combined these laboratory measurements with in situ microsensor measurements of tissue O2 and H2S concentrations. Net photosynthesis rates in leaves with fine sediment particles were down to ~20% of controls without particles, and the compensation photon irradiance increased from a span of 20–53 to 109–145 μmol photons m−2 s−1. An ~2.5-fold thicker DBL around leaves with fine sediment particles impeded O2 influx into the leaves during darkness. In situ leaf meristematic O2 concentrations of plants exposed to fine sediment particles were lower than in control plants and exhibited long time periods of complete meristematic anoxia during night-time. Insufficient internal aeration resulted in H2S intrusion into the leaf meristematic tissues when exposed to sediment resuspension even at relatively high night-time water-column O2 concentrations. Fine sediment particles that settle on seagrass leaves thus negatively affect internal tissue aeration and thereby the plants' resilience against H2S intrusion.
Aurora A activation in mitosis promoted by BuGZ

we report that BuGZ promotes Aurora A (AurA) activation in vitro. Depletion of BuGZ in cells reduces the amount of phosphorylated AurA on spindle MTs. BuGZ also enhances MCAK phosphorylation. The two zinc fingers in BuGZ directly bind to the kinase domain of AurA, which allows AurA to incorporate into the coacervates formed by BuGZ in vitro. Importantly, mutant BuGZ that disrupts the coacervation activity in vitro fails to promote AurA phosphorylation in Xenopus laevis egg extracts. These results suggest that BuGZ coacervation promotes AurA activation in mitosis.
Role of genital tract infections and inflammatory processes in male infertility

Inflammation and male genital tract infections could interfere with the spermatogenesis process and lead to damages in sperm quality, as well as to seminal tract obstruction, being thus considered two of the most important causes of male infertility. Therefore, currently, there is an acute need for a better standardization of the methodology used in the clinical practice to detect and identify microorganisms infecting the male urogenital tract and also for the correct diagnosis of inflammatory processes correlated with male infertility. This paper aims to review some of the physiological changes of the main determinants of sperm quality induced by inflammatory and infectious processes, such as increased seminal leucocytes, oxidative stress and cytokines production.
Identifikation besonderer beruflicher Problemlagen mittels des Screening-Instrumentes SIMBO. Eine Synopse von vier Kohortenstudien

Zusammenfassung Fragestellung Der Artikel hat das Ziel die bestehenden Erkenntnisse hinsichtlich der prädiktiven Güte des SIMBO für die deutsche Reha-Population zusammenzufassen. Material und Methoden Daten der bisherigen Kohortenstudien wurden verwendet. Dort erfolgte eine Erhebung des SIMBO zu Beginn der Rehabilitation. Das Outcome – Probleme bei der beruflichen Wiedereingliederung – wurde 3 Monate nach Reha-Ende erhoben. Alle Analysen wurden in Bezug auf Erkrankung und Geschlecht auf die Verteilung der Reha-Leistungen der Deutschen Rentenversicherung des Jahres 2015 gewichtet. Ergebnisse Neun Erkrankungsgruppen wurden integriert (n=2422). 35% (32–39%) der Befragten wiesen berufliche Probleme nach der Reha auf. Personen mit diesen hatten mit 48 Punkten einen um 35 Punkte höheren SIMBO-Wert als Personen ohne diese. Bei einem SIMBO-Trennwert von 20 Punkten konnten indikationsübergreifend 89% (85–93%) aller Personen mit beruflichen Problemen erkannt werden. Für die Erkrankungsgruppen wurden unterschiedlich optimale Trennwerte ermittelt. Schlussfolgerungen Die Ergebnisse sind der bislang stärkste Nachweis für die Güte eines Screenings in der Rehabilitation. Der Einsatz des SIMBO im Vorfeld der medizinischen Rehabilitation kann danach empfohlen werden.
The problem of bacterial complications post respiratory viral infections

Every person over the course of their lifetime is repeatedly infected by a variety of respiratory viruses that represent risk factors for the development of bacterial complications. The most dangerous among the etiological factors of acute respiratory viral diseases is the influenza A virus. This virus is capable of causing catastrophic pandemics with high mortality mainly due to secondary bacterial pneumonia. As has been shown in numerous recent studies, the main mechanism of provoking bacterial infections irrespective of the type of respiratory virus is the imbalanced response of the antiviral innate immunity – excessive interferon response and uncontrolled inflammation. The probability of severe bacterial complications in the course of acute respiratory viral infections is determined by both the virulence of the virus itself and by the composition of the respiratory microbiota at the time of the viral infection as well as by the genetic characteristics of the organism. The occurrence of severe bacterial complications is also affected by the chronic diseases that have an impact on the regulation of the innate immune response. This review summarizes the current concept of the mechanisms of the development of post viral bacterial complications as well as the potential prevention strategies for these complications.
FATHER’S CHILDHOOD EXPERIENCE, DEPRESSION AND ANXIETY SYMPTOMS IN PERINATAL PERIOD AND THEIR INVOLVEMENT IN INFANT CARE

The aim of this research is to make a longitudinal study of the associations between men’s childhood experience and their involvement in infant care, also, whereas psychological state of a future father during child’s perinatal period affect their involvement in infant care. The research consists of two stages. In the first stage, 43 respondents took part – men between the ages of 23 and 40, who, at the moment of the research, for the first time had prepared themselves to become fathers and their children’s mothers were on the last trimester of pregnancy. In the second stage of the research (after childbirth) from 43 respondents 27 young fathers gave their feedback. Fathers completed the Traumatic Antecendents Questionnaire (Herman & Van der Kolk, 1989), The Gotland Male Depression Scale (Zierau et al., 2002), The State-Trait Anxiety Inventory (Spielberger, Gorsuch, Lushene, Vagg, & Jacobs, 1983), as well as The Newborn Care Involvement Self-Assessment Inventory which was made for the present research. Results shoved that father’s involvement in infant care is not associated with their childhood experience, but is positively predicted by the state anxiety and negatively – by the trait anxiety. Statistically significant differences between prenatal and postnatal measurements exist only for the state of anxiety.
Detecting Brain Tumor using Machines Learning Techniques Based on Different Features Extracting Strategies.

BACKGROUND Brain tumor is the leading cause of death worldwide. It is obvious that the chances of survival can be increased if the tumor is identified and properly classified at an initial stage. MRI (Magnetic Resonance Imaging) is one source of brain tumors detection tool and is extensively used in the diagnosis of brain to detect blood clots. In the past, many researchers developed Computer-Aided Diagnosis (CAD) systems that help the radiologist to detect the abnormalities in an efficient manner. OBJECTIVE The aim of this research is to improve the brain tumor detection performance by proposing a multimodal feature extracting strategy and employing machine learning techniques. METHODS In this study, we extracted multimodal features such as texture, morphological, entropybased, Scale Invariant Feature Transform (SIFT), and Elliptic Fourier Descriptors (EFDs) from brain tumor imaging database. The tumor was detected using robust machine learning techniques such as Support Vector Machine (SVM) with kernels: polynomial, Radial Base Function (RBF), Gaussian; Decision Tree (DT), and Naïve Bayes. Most commonly used Jack-knife 10-fold Cross- Validation (CV) was used for testing and validation of dataset. RESULTS The performance was evaluated in terms of specificity, sensitivity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), False Positive Rate (FPR), Total Accuracy (TA), Area under the receiver operating Curve (AUC), and P-value. The highest performance of 100% in terms of Specificity, Sensitivity, PPV, NPV, TA, AUC using Naïve Bayes classifiers based on entropy, morphological, SIFT and texture features followed by Decision Tree classifier with texture features (TA=97.81%, AUC=1.0) and SVM polynomial kernel with texture features (TA=94.63%). The highest significant p-value was obtained using SVM polynomial with texture features (P-value 2.65e-104) followed by SVM RB with texture features (P-value 1.96e-98). CONCLUSION The results reveal that Naïve Bayes followed by Decision Tree gives highest detection accuracy based on entropy, morphological, SIFT and texture features.
Evre IIIB Endometrioid Tip Endometrium Kanser Olgularının Analizi: Tersiyer İki Onkolojik Merkez Deneyimi

Aim: The objective of this study was to analyzestage IIIB endometrioid type endometrial cancer. Material and Methods: This study was conducted in two gynecologic oncology centers between January 2007 and December 2016. Endometrial cancer was staged according to the International Federation of Gynecology and Obstetrics (FIGO) staging system and stage IIIB endometrioid type endometrial cancer patients were included in the study.The clinicopathologic findings of the patients were analyzed by reaching through the hospital database. Result: A total of 1700 endometrial cancer patients were investigated and of these patients, 10 were diagnosed with stage IIIB endometrioid type endometrial cancer. The median age of the patients were 62 years (49-85) and the median follow-upwas 45 months (20-93). Four and four patients were diagnosed with vaginal involvement andparametrial involvement, respectively. Two patients were diagnosed withboth vaginal and parametrial involvement. Six (60%) patients underwent radical hysterectomy and 4 (40%) patients underwent simple hysterectomy. Six patients received adjuvan chemotherapy. Only one patient received adjuvan pelvic radiotherapy whereas 3 patients received adjuvan vaginal brakitherapydue to advanced age. There were four recurrent cases.The five-year disease-freesurvival (DFS) rate and overall survival (OS) rate was 50% and 66.7%, respectively. Conclusion: Stage IIIB endometroid type endometrium cancer represents a rare specific subgroup of endometroid type endometrium cancer. As our knowledge this is the only study in the national literature. There is need for multi-center studies involving large number of patients.
Posturographic measures did not improve the predictive power to identify recurrent falls in community-dwelling elderly fallers

OBJECTIVE: This study aimed to evaluate if posturography can be considered a recurrent fall predictor in elderly individuals. METHODS: This was a cross-sectional study. A total of 124 subjects aged 60 to 88 years were evaluated and divided into two groups—the recurrent fallers (89) and single fallers (35) groups. Patients' sociodemographic characteristics were assessed, and clinical testing was performed. The functional test assessment instruments used were timed up and go test (TUGT), Berg Balance Scale (BBS), five times sit-to-stand test, and Falls Efficacy Scale (to measure fear of falling). Static posturography was performed in a force platform in the following three different situations—eyes open (EO), eyes closed (EC), and EO dual task. RESULTS: There were significant differences between the single and recurrent fallers groups regarding the fear of falling, the Geriatric Depression Scale score, the mean speed calculated from the total displacement of the center point of pressure (COP) in all directions with EO, and the root mean square of the displacement from the COP in the mediolateral axis with EC. Based on the hierarchical logistic regression model, none of the studied posturographic variables was capable of significantly increasing the power of differentiation between the recurrent and single fallers groups. Only TUGT with a cognitive distractor (p<0.05) and the BBS (p<0.01) presented with significant independent predictive power. CONCLUSION: TUGT with a cognitive distractor and the BBS were considered recurrent fall predictors in elderly fallers.