Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of a Mobile App to Improve Numeracy Skills of Children With Autism Spectrum Disorder: Participatory Design and Usability Study

Background The use of information and communication technologies is transforming the lives of millions of people including children with autism spectrum disorder (ASD). However, the process of developing a user-friendly and effective mobile app needs to follow a complex standard protocol and culture-sensitive customization, and involves multiple sectors. This complex work becomes even more challenging when considering children with ASD in low- and middle-income countries as the users. Objective This study aimed to design and develop a more intuitive mobile app to improve numeracy skills of children with ASD in Rwanda and evaluate the usability of the app. Methods A participatory design approach was utilized in this study in which 40 children with ASD, 5 teachers, and 10 parents of children with ASD participated in focus group discussions (FGDs) and usability testing. A narrative literature review was performed to explore existing mobile apps and compare previous studies to design the questions for FGD and facilitate a framework for designing the app. The agile methodology was used to develop the mobile app, and the heuristics evaluation method was used to test and evaluate the usability of the initial version of the app to improve its functionalities. The interviews were recorded, transcribed, and analyzed following the guidelines of the qualitative narrative analysis (QNA) method. Results During the FGDs the respondents shared their need for a mobile app in teaching and learning numeracy for children with ASD and pointed to possibilities of integrating the mobile app into existing curriculum. Ten themes emerged from the FGDs and exercise of developing the mobile app. The themes were related to (1) teaching and learning numeracy for children with ASD, (2) planning and development of a mobile app for a person with ASD, (3) testing a mobile app, (4) strength of the developed app against the existing ones, (5) behavioral maintenance and relapse prevention, (6) possibilities to integrate the mobile app into the existing curriculum, (7) data protection for users, (8) social implications, (9) challenges in Rwanda, and (10) focus on future. Conclusions The community plays an important role in the planning, development, and evaluation of a mobile app for children with ASD. In this study, inputs from teachers and parents resulted in an optimally designed mobile app that can improve numeracy skills in children diagnosed with ASD to support the implementation of competency-based curriculum in Rwanda.
Formation of Pungent Principles in Fruits of Sweet Pepper, Capsicum annuum L. var. grossum during Post-harvest Ripening under Continuous Light

Pungent principles (Capsaicinoid(s)) were found to be produced in fruits of sweet pepper, Capsicum annuum L. var. grossum, during post-harvest ripening under continuous light. The initial formation was observed after 4 days’ ripening. After 7 days’ ripening, the capsaicinoids content in placenta increased to 12.9 μg per fruit, which was 2.5-fold of that in pericarp. No pungent principles were detected in fruits during ripening in the dark and in seeds under continuous light. In placenta, the formation of dihydrocapsaicin and nordihydrocapsaicin which are the vanillylamides of saturated branched fatty acids was higher than that of capsaicin which is the vanillylamide of an unsaturated one. Remarkable formation and accumulation of carotenoid were also observed during post-harvest ripening under continuous light.
Comparative study on fasting and postprandial lipid profile in type 2 diabetes mellitus

Context: Postprandial dyslipidemia plays a vital role in the pathogenesis of atherosclerosis and possible macrovascular complications in type 2 diabetes mellitus (DM). Aims: To assess and compare the fasting and postprandial lipid profiles in type 2 DM patients. Settings and Design: This case-control study was conducted in the Medicine department of a tertiary care teaching hospital. Methods and Materials: The study included 100 subjects; 50 type 2 diabetic patients and 50 healthy age- and gender-matched controls. Fasting and postprandial lipid levels were estimated in all the subjects and compared. Statistical Analysis Used: The Student's t-test and the analysis of variance (ANOVA) test were used for comparison between two and more than two groups, respectively, for normally distributed data. Results: Mean total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) levels were significantly higher and high density lipoprotein (HDL) level was significantly lower in the diabetics in comparison to the controls in both fasting (200.82, 172.59, 126.20, 37.63, and 40.74 mg/dL in diabetics versus 179.90, 98.03, 109.54, 19.60, and 50.46 mg/dL in controls) and postprandial states (223.75, 232.99, 139.19, 46.52, and 40.54 mg/dL in diabetics versus 185.36, 102.20, 110.36, 20.24, and 48.96 mg/dL in controls). The mean postprandial TC and TG levels (223.75, 232.99 mg/dL) in diabetics were significantly higher when compared to their fasting values (200.82, 172.59 mg/dL) in these patients. Conclusions: Type 2 DM patients show significant postprandial lipid abnormalities particularly postprandial hypertriglyceridemia. Raised postprandial lipid parameters highlight that estimating lipids in the postprandial state is equally important as is estimation of lipids in the fasting state in type 2 DM.
MiR-125b is a Potential Protector of Arteriosclerosis Occlusive: Restricting the Proliferation and Migration of Vascular Smooth Muscle Cells via Decreasing the Level of AAMP and SRF.

Arteriosclerosis occlusive (ASO) is a manifestation of atherosclerosis (AS), and it is one of the main causes of lower limb ischemic necrosis in the elderly. Excessive proliferation and migration of vascular smooth muscle cells is one of the main causes of ASO, but the mechanism is unclear. MiR-125b is a tumor suppressor, which can inhibit the proliferation and migration in various kinds of tumors. At the same time, we find miR-125b is the most obviously down-regulated microRNA in ASO. Therefore, we explore the role of miR-125b in ASO. This study shows that up-regulated miR-125b inhibits the proliferation of vascular smooth muscle cells through CCK8 assay and Brdu assay. Meantime, the up-regulation of miR-125b restricts the migration of vascular smooth muscle cells through trans-well assay and wound healing assay. Furthermore, this study finds that up-regulated miR-125b inhibits the expression level of angio-associated migratory cell protein (AAMP) and serum response factor (SRF), which may be an important way for miR-125b to regulate the proliferation and metastasis of smooth muscle cells.
A real time non-invasive cholesterol monitoring system

Hypercholesterolemia causes cardiovascular disease which is a disorder of the heart and blood vessels, one of the most significant causes of death in the world, and this needs to be anticipated by monitoring blood cholesterol levels regularly. The current method of monitoring blood cholesterol levels is using invasive technique by collecting blood samples. A simple device is needed to measure blood cholesterol levels that can be done without collecting blood samples. This study aims to develop a non- invasive technique for monitoring blood cholesterol levels using sensors utilizing infrared light absorption in body tissues, in order to simplify measuring blood cholesterol levels regularly for patients with hypercholesterolemia. The application of a non-invasive technique focused on developing a total blood cholesterol monitoring device using an infrared sensor with IR LED - 940nm wavelength as a transmitter. A photodiode was used as a detector with the wavelength range of 400-1100 nm and a microcontroller as the minimum system for controlling the value of the output voltage in the form of digital data and then converted onto total blood cholesterol. The measurement results using non-invasive technique was compared to the results using invasive technique.
Chaotropic effect of trifluoroacetic and perchloric acid on B-cyclodextrin inclusion complexation process with risperidone, olanzapine and their selected impurities

Effective method development together with method`s eco-friendly character are gaining importance in drug analyses nowadays. One of the strategies often applied to improve the efficacy of separation methods, especially in the case of basic ionizable analytes is adding chaotropic salts into the mobile phases. Moreover, the development of the green liquid chromatography method could also be achieved with certain mobile phase additives such as cyclodextrin (CD). The study aims to investigate whether adding chaotropic agents could improve the complexation process by disrupting the analytes' water solvation shell. The model mixture consisted of risperidone, olanzapine, and their related impurities. Method development was aided with experimental design methodology, while optimal separation conditions were selected using Derringer's desirability function. Mathematical models obtained for each of the examined responses enabled the explanation of the single and simultaneous influence of b-CD concentration, chaotropic agents type, and content, as well as the content of acetonitrile in the mobile phase. Retention factors appeared to be the most influenced by acetonitrile content in the mobile phase. The type of chaotropic agent as well as its concentration lead to retention prolongation, but if acetonitrile content in the mobile phase is high, the effect of chaotropic agent becomes negligible. Interaction between analyte and b-CD are relatively weak in comparison to the interaction of analyte form with either chaotropic agent or acetonitrile. Interaction leading to complexation are outperformed by other analyte related interactions in this complicated system, so complexation based retention reduction is not fully exposed. However, increasing b-CD concentration shows a positive effect on the resolution between critical peak pairs. Optimal separation conditions were selected based on 3D plots of Derringer's desirability function. For olanzapine and its impurity, they included the following: acetonitrile content 16% (v/v), trifluoroacetic acid as a chaotropic agent with 0.95% (v/v) content, and 9 mM b-CD concentration. Further, optimal separation conditions for risperidone and its impurity were 25% (v/v) acetonitrile content in the mobile phase, trifluoroacetic acid as chaotrope agent with 0.27% (v/v) content and 5mM b-CD concentration.
Soluble microbial product formation during biological treatment of fermentation industry effluent

The most important factor that affects the quality of effluents and overall organic matter removal in biological treatment processes is the presence of soluble microbial products (SMP) that are produced during biological treatment and remain in effluent. High strength wastewater from fermentation industry (FIE) was used as a slowly degradable substrate to investigate SMP formation in aerobic and anaerobic treatment. For SMP determination which forms a major part of residual soluble COD of the wastewater, the initial inert soluble COD (S I ) was determined. It was found that S I /S o is 0.122 and 0.164 for aerobic and anaerobic processes, respectively. During aerobic treatment of FIE for initialCOD (S o ) values varying between 1540–6645 mg COD/L, SMP are expected to vary within the range of 12.5–8.6% of So, respectively. In anaerobic treatment of the FIE, for values of 2670–6585 mg COD/L, SMP are expected to vary within the range of 9.8–6.2% of S o , respectively. Molecular weight distribution analyses of raw wastewater, aerobic and anaerobic treatment effluent indicate that in both systems the effluent of FIE presents similar molecular weight fractions and are very high compared to raw wastewater.
Fluorine prefers hydrogen bonds over halogen bonds! Insights from crystal structures of some halofluorobenzenes

Abstract Crystal structures of a series of isomers of chlorofluorobenzene, bromofluorobenzene and iodofluorobenzene, all of which are liquids under ambient conditions, are determined by a technique of in situ cryocrystallography. These simple dihalo substituted benzenes provide clear insights into subtle interplay of packing interactions preferred by fluorine and heavier halogens for example, C–H···X hydrogen bonds vs. X···X halogen bonds (X=F, Cl, Br, I). The interaction patterns noted here are purely characteristic of halogens, having not been influenced by other stronger interactions. Variability of principal supramolecular synthons among the isomers highlights the importance of molecular shape and relative position of interacting atoms while preserving the basic intermolecular bonds. Mutually exclusive occurrence of homo (I···I) and hetero (I···F) halogen bonds in polymorphs of 4-iodofluorobenzene questions the robustness and reliability of these interactions.
Leaching of Low Grade Copper Ore

銅は,青 銅 として最 も古 くか ら人類 に利用 され てきた 金属であ り,導 電性,加 工性,価 格 な どの点 で他 に代 え 難い優れた性質を持つ ことか ら,合 金材料,伸 銅製 品, 電線材料な ど様々 な用途に使用 され ている。 このため, 銅は,鉄 や アル ミニウムな どと共 に現代文 明を支 える最 も重要かつ基本的な金属のひ とつに数 え られ,そ の生産 量は年 々増加 してい る。 しか し,新 規鉱床 の深部化,鉱 石 の低品位化 お よび発展途 上 国での消費 の増 加な どか ら,比 較的近い将来に供給障害が生 じる可能性がある と 指摘 されて いる1)。 従来,銅 は,坑 内堀 りあ るいは露 天掘 りで採掘 された 鉱石(原 鉱)を 粉砕 し,こ れか ら浮選に よ り得た銅精鉱 を乾式精錬す る方法 で生産 されて きたが,通 常,こ の方 法 では銅 品位0. 5%以 上 の原鉱 しか処理 で きない。 他方, 近年,従 来法 では処理で きない低品位鉱か ら銅を回収す るためにダン プ リーチン グや ヒープ リーチン グな どの方 法 が実施 され る ようになって きてい る。 これ らの方法に よ り生産 され る銅量 は,1994年 の時点で世界 の産銅量の 9%以 上を 占め2),さ らに年々 増 加す る傾 向に ある。 ま た,こ れ らの方法 は,従 来法 と違 って大気汚染物質であ るSOxを 発生 させな いこともあ り,銅 の安定供給 と環 境 に対す る負荷低減 の両面か ら,今 後,ま す ます重要に な って くるもの と考 え られ る。 しか し,最 も重要 な銅鉱 物であ る黄銅鉱 の浸出速度 が遅 いことか ら,そ の浸 出性 改善策を確 立す ることが重要 な課題 となっている。 本稿では,低 品位銅鉱 の リーチン グの原理 と実施法に ついて述べ る とともに,黄 銅鉱 の浸出促進剤 に関す る研 究について概観す る。
INVESTIGATION OF THE RELATIONSHIP BETWEEN HEALTHY LIFESTYLE BEHAVIOR OF HEALTH PROFESSIONALS AND USE OF HEALTH CARE SERVICES: A RESEARCH ON ATTITUDES FOR VACCINE APPLICATIONS

The main purpose of this study is to examine the relationship between the healthcare professionals' level of showing healthy lifestyle behavior and their attitudes towards the use of healthcare services. The universe of the research is the middle and/or upper level managers of the general private hospitals operating in Istanbul under the umbrella of the Republic of Turkey Ministry of Health Private Health Institutions. In the study in which the quantitative research method (quantitative research design) was used, the data were collected by face-to-face questionnaire technique (the total number of questionnaires that were used and evaluated in the analysis is 390). In the study; descriptive statistics, explanatory factor analysis, multiple linear regression analysis and confirmatory factor analysis techniques were used. SPSS and AMOS package programs were used together in the analysis of the data. According to the results of multiple linear regression analysis of the research; it has been determined that the healthcare professionals' attitudes towards healthy lifestyle affect their attitudes towards vaccine practices positively and statistically significant. According to the results of the confirmatory factor analysis; it is seen that the majority of the fit indices of the proposed research model are at the acceptable fit level. Corresponding Author Fuat YALMAN DOİ https://10.48121/jihsam. 777815
Meat tenderization using bromelain enzyme extracted from pineapple waste

Tenderization is an important method to improve the quality and palatability of meat. In comparison to conventional chemical and physical methods of meat tenderization, enzymatic treatment is more economical and healthy. In the present study proteolytic enzyme bromelain was used for this purpose. Bromelain enzyme was extracted from pineapple, quantified and optimized concentration was used for treating the muscle fibre of meat. Tenderness was measured. pH and cooking loss were not significantly (P>0.05) decreased, but water-holding capacity and protein content were significantly (P<0.05) increased with the concentration and ageing. Duration of marination was optimized and SDS- PAGE electrophoresis was conducted to estimate protein. The results proved that bromelain enzyme is an effective method of tenderization used to improve the quality of meat.
Tracking the thermal decomposition of plasma-sprayed hydroxylapatite

Abstract In modern orthopedics, plasma-sprayed hydroxylapatite coatings are applied routinely to metallic parts of hip and knee prostheses, as well as to dental root implants to render them osseoconductive, that is, able to assist the body in creating new bone by ingrowth of bone cells, blood capillaries, and soft tissue. In this work, hydroxylapatite coatings were deposited by atmospheric plasma spraying on titanium alloy substrates, and characterized by synchrotron radiation X‑ray diffraction and solid-state nuclear magnetic resonance spectroscopy. The deposition parameters were varied using a statistical design of experiments methodology. Depending on the degree of heat input and heat transfer rates, (1) dehydroxylated hydroxylapatite phases such as oxy- and oxyhydroxylapatite, (2) thermal decomposition phases (tri- and tetracalcium phosphates, CaO), and (3) amorphous calcium phosphate were formed. Implications of this research are that oxyapatite appears to be unstable at ambient conditions, and that proper selection of intrinsic plasma-spray parameters is key to the chemical stability and mechanical performance of the coating.
Seabuckthorn Berries Attenuate Pulmonary Vascular Hyperpermeability in Lipopolysaccharide-induced Acute Lung Injury in Mice

Background Acute lung injury is featured by pulmonary vascular hyperpermeability, resulting in high short-term mortality. Currently pharmacological therapies are still sparse. Methods In the mice model of acute lung injury induced by Lipopolysaccharide, the effect of seabuckthorn berries extract on pulmonary vascular hyperpermeability was evaluated by histopathologic observation and transvascular leakage determination. The key factors involved in alveolar-capillary barrier lesion were assessed. Results The findings indicated that treatment of seabuckthorn berries alleviated morphological lesion as well as water, Evans blue and total proteins leakage in lung tissue, suppressed the release of TNF-α and IL-6, decreased accumulation of neutrophils, inhibited the activation of NF-κB and down-regulated the expression of ICAM-1 and CD62E. Conclusions These results demonstrated seabuckthorn berries help maintaining alveolar-capillary barrier integrity under endotoxin challenge in mice by suppressing the key factors in the pathogenesis of acute lung injury.
Electro-optical Characteristics of Aqueous Graphene Oxide Dispersion Depending on Ion Concentration

Facile alignment control of graphene oxide (GO) particles in aqueous dispersions is a highly useful technique for various potential applications. Aqueous GO dispersions were recently reported to have an extremely large Kerr coefficient, which may provide a valuable pathway to the alignment control of GO particles. We investigated the electro-optic responses of GO dispersions in various ionic solutes and with varying ionic concentrations. We found that the addition of NaOH actually improved the electro-optic sensitivity of the GO dispersion, while other ionic additives resulted in desensitization. We experimentally and theoretically elucidated the underlying mechanism of the phenomena. The mechanism is closely related to the acidic nature of the GO dispersion, which is neutralized by the addition of NaOH. The addition of ionic solutes caused only a mild change in the surface conductivity of GO particles, but it brought about a large variation in the bulk solvent conductivity. The electro-optical sensitivit.
Integrated analysis of miRNA-mediated ceRNA networks in ovine skeletal muscle development

Background: The embryo stage is a key period for sheep skeletal muscle growth and development. Proliferation, differentiation, and hypertrophy of fibers affect muscle growth potential directly. Analyzing transcriptome data is of great significance for revealing important time nodes of fetus muscle development and screening related regulation factors. Muscle development is a complex biological process, including a intricate network of multiple factor interactions. Among them, non-coding RNA, especially miRNA-mediated regulation, plays a fine regulatory role. The purpose of this study was to investigate the important genes and transcripts involved in the genetic mechanism of embryos skeletal muscle development in late pregnancy. Results: Herein we did a small RNA sequencing(RNA-Seq) of embryo at 85 days (D85N), 105 days (D105N) and 135 days(D135N), then performed bioinformatic analysis in order to identify the miRNA-mediated co-expression networks. Our findings identified 505 DE-miRNAs. Integrating the current miRNA data and the previously obtained lncRNA data, multiple networks were constructed, including miRNA-mRNA, miRNA-target gene(TG)-pathway, lncRNA-miRNA-mRNA, and miRNA-TG-transcription factor (TF) network. The results showed that the miRNA-mRNA network and lncRNA-miRNA-mRNA network identified three important lncRNAs (MSTRG.3533, MSTRG.4324, and MSTRG.1470) and three miRNAs(miR-493-3p, miR-3959-3p and miR-410-5p). The four genes ( TEAD1 , ZBTB34 , GSK3B, and POGLUT1 ) and three transcription factors (C / EBPbeta, TFIID, and PR B) play a key regulatory role in the miRNA-TG-TF network. Notably, a similar trend of gene expression was reported by RT-qPCR for RNA-seq data. Conclusions: This study identified three miRNAs, three lncRNAs, four genes, and three transcription factors, and revealed their crucial role in fetal fibrogenesis and lipid metabolism. It also shows that D105N is a pivotal turning point from myotube differentiation to fiber hypertrophy. These findings provide valuable references for network interaction patterns, which helps to evaluate the biological significance of skeletal muscle in the late development stage.
Behavior and non-behavior Predictors of seat belt use amongst Iranian Bus Passengers

Background: No behavior as much as the use of a seatbelt affects the reduction of the severity of injuries caused by driving accidents. So far, there has not been sufficient evidence of predictive factors regarding the use of seatbelts in bus passengers. The purpose of this study was to determine the predictors of seatbelt use in passengers of intercity buses. Methods: In this cross-sectional study, 458 passengers of intercity bus terminals participated. The sampling method was multistage in this study. To collect data, a researcher-made questionnaire whose validity and reliability were confirmed was used. The collected data were analyzed using SPSS software version 22 and logistic regression test. Results: The study population included 47% of men and 53% of women with an average age of 28.35 ± 6.1. Police stations, high bus speeds, night, and inappropriate weather conditions were among the situations in which the use of a seatbelts was more on the bus. The results of the logistic regression test in the third model showed that perceived barriers, law and supervision, subjective norms, environment, and bus type predict the use of seat belts significantly (P <0.000). Conclusions: It seems that in addition to interventions designed to increase the knowledge and attitude of passengers and enhance the use of seatbelts on the bus, a special look is also needed at important people who influence the behavior of the people (subjective norms).