Miracle-dz/UniFAR-FTUs huggingface dataset:
Detecting Autism Spectrum Disorder in Children With ADHD and Social Disability

Objective: The social disability associated with ADHD often makes diagnostic and treatment decision making challenging. This protocol investigates the test performance of the Autism Mental Status Exam (AMSE) in detecting autism spectrum disorder (ASD) in a sample of 45 children with ADHD and ASD symptomatology. The AMSE is a brief ASD diagnostic assessment administered in the context of a clinical exam. Method: All participants received a developmental evaluation, including the AMSE, followed by independent gold standard diagnostic assessments including the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview–Revised (ADI-R). Results: Receiver operating characteristics (ROC) curve analysis indicated strong sensitivity and specificity in this population. Optimal cutoff scores are provided. Conclusion: The AMSE holds promise as a brief ASD assessment tool for children with ADHD and ASD symptomatology and as a guide for treatment and referral decisions at the point of care.
Acoustic nature of the whisper

The lower formant frequencies of the whispery vowel are known to be slightly higher than those of the modal vowel. This paper attempts to interpret this phenomenon acoustically, based on an electrical circuit model of the vocal tract, taking into account acoustic coupling with the subglottal system. A three-dimensional vocal tract shape was measured from a magnetic resonance image (MRI). It was found that the narrowing of the tract in the false vocal fold regions and weak acoustic coupling with the subglottal system are primary causes of the rise of the lower formant frequencies.
SLA-Aware Profit Optimization in Cloud Services via Resource Scheduling

In this paper, we present our analysis of resource scheduling to achieve SLA-aware profit optimization in cloud services. This work is part of a real system called Intelligent Cloud Database Coordinator (ICDC), which is being built at the NEC Labs to manage very large cloud service delivery infrastructures. As we present in our performance evaluation, the analysis shows that the choice of resource scheduling policy makes a significant difference in SLA delivery and total profit of the cloud service provider.
Application of data mining techniques for customer lifetime value parameters: a review

Computational and digital advancements with the advent of relationship marketing have changed the land signs of business. Digital revolution led to generation and collection of data in companies and extracting knowledge from this data through knowledge discovery in databases (KDD) process. KDD involves many steps, of which an important step is data mining. Data mining is a process of extracting patterns in data through statistical and other techniques and algorithms. In business, firms are shifting their marketing approach from mass marketing to relationship based marketing leading to an era of customer relationship management (CRM). CRM requires sustainable long term relationship with customers and allocation of resources to maintain these relationships. Customer lifetime value (CLV) is a metric to justify resource allocation by segregating customers on the basis of their contribution to the company. In this paper we review applications of statistical and data mining techniques for predicting CLV and its parameters. The applications of techniques such as logistic regression, decision trees, artificial neural networks, genetic algorithms, fuzzy logic and support vector machines are covered. In the end, a case study is presented to estimate few CLV parameters for a direct marketing company.
Research on organizational commitment status quo of P.E teachers in general universities and colleges

This paper Investigated 280 P.E teachers in some universities from the provinces of Hubei, Hunan, Zhejiang, Jiangsu, the purpose is to explore the organizational commitment of P.E teachers in General Universities and Colleges. Descriptive statistics on the recalled valid questionnaire indicate that the scales of P.E teachers' organizational commitment and its dimensions are higher than the mean, and the scales is middling-ascending, especially the scales of normative commitment; In order to explore influence to organizational commitment of the variables of demology, stepwise regression analyses indicate that the organizational commitment and its' dimensions of lecturer is lower than assistant and associate professor (upwards).
Hand Hygiene Intervention Strategies to Reduce Diarrhoea and Respiratory Infections among Schoolchildren in Developing Countries: A Systematic Review

Effective and appropriate hand-washing practice for schoolchildren is important in preventing infectious diseases such as diarrhoea, which is the second most common cause of death among school-age children in sub-Saharan Africa. The objective of the review was to identify hand hygiene intervention strategies to reduce infectious diseases such as diarrhoea and respiratory tract infections among schoolchildren aged 6–12 years in developing countries. Published research articles were searched from databases covering a period from as far back as the creation of the databases to November 2015. Eight randomized controlled trials (RCT/CRCT) from developing countries met the inclusion criteria. The Jadad Scale for appraising RCT/CRCT studies revealed methodological challenges in most studies, such that 75% (6/8) were rated as low-quality articles. The review found that hand hygiene can reduce the incidence of diarrhoea and respiratory conditions. Three hand hygiene intervention strategies utilized were training, funding and policy, with training and funding implemented more commonly than policy. These strategies were not only used in isolation but also in combination, and they qualified as multi-level interventions. Factors that influenced hand washing were contextual, psychosocial and technological. Findings can inform school health workers in categorizing and prioritizing activities into viable strategies when implementing multi-level hand-washing interventions. This review also adds to the existing evidence that multi-level hand-washing interventions can reduce the incidence of diarrhoea, respiratory infections, and school absenteeism. Further evidence-based studies are needed with improved methodological rigour in developing countries, to inform policy in this area.
Invasion and replication of Salmonella typhimurium in animal cells

A total of 81 avirulent Tn10 insertion mutants of Salmonella typhimurium have previously been described. These mutants were selected for the inability to survive in murine macrophages. We have characterized the abilities of the most avirulent of these mutants to adhere to, invade, and replicate in both macrophages and nonphagocytic epithelial cells. The results suggest that most mutants contain a defect that is specific to survival within professional phagocytes. These mutants invaded and replicated normally within nonphagocytic human colon adenocarcinoma cells (Caco-2) but did not survive in the macrophage cell line J774. One mutant invaded both macrophages and epithelial cells much less efficiently than the parental strain. The defect associated with this mutant appears to be a result of decreased adherence to animal cells.
Temporal colinearity in expression of anterior hox genes in developing chick embryos

Temporal colinearity describes a correspondence between the spatial ordering of Hox genes within their clusters (in the direction 3′ to 5′) and the time of their first expression (earlier to later) during embryonic development (Izpisúa‐Belmonte et al. [1991] EMBO J. 10:2279–2289). It suggests that activation of each Hox gene might be controlled in some way by its position within the cluster. So far, in situ hybridization experiments on vertebrate embryos have provided clear evidence of temporal colinearity only for “posterior” Hox genes (5′ located, AbdB related). We now describe a search in the chick embryo for evidence of temporal colinearity in the expression of some anterior Hox genes (Hoxb‐1, b‐3, b‐4, b‐6, and a‐9). Clear evidence for temporal colinearity was seen in neural tube tissue adjacent to the first few somites. Here, there were delays in the expression of Hoxb‐3 following b‐1, Hoxb‐4 following b‐3, and Hoxb‐6 following b‐4. Temporal colinearity was also detected in anterior primitive streak tissue. Hox gene expression reached both the neural tube and the anterior streak following forward spreading from posteriormost parts of the primitive streak. Overall, therefore, temporal colinearity was seen as sequential waves of Hox gene expression that proceeded forward (3′ genes before 5′ genes) along the developing chick embryo. Within posterior primitive streak tissue, there was only limited evidence for temporal colinearity. We discuss these results in terms of possible models for the establishment of Hox gene expression patterns. © 1996 Wiley‐Liss, Inc.
Differential HIV risk in bathhouses and public cruising areas.

OBJECTIVES This report investigates differences in risk behaviors among men who have sex with men (MSM) who went to gay bathhouses, public cruising areas, or both. METHODS We used a probability sample of MSM residing in 4 US cities (n = 2,881). RESULTS Men who used party drugs and had unprotected anal intercourse with nonprimary partners were more likely to go to sex venues than men who did not. Among attendees, MSM who went to public cruising areas only were least likely, and those who went to both public cruising areas and bathhouses were most likely to report risky sex in public settings. CONCLUSIONS Distinguishing between sex venues previously treated as a single construct revealed a significant association between pattern of venue use and sexual risk. Targeting HIV prevention in the bathhouses would reach the segment of men at greatest risk for HIV transmission.
Numerical Study of Thermal Management and Validating Experiments of a Data Center

The worldwide demand for storage of data continues rapidly so the number and size of the data center are increasing constantly. Significant power consumption is dedicated in the U.S in 2006 nearly 1.5% percent of overall electricity consumption in the U.S. and as a matter of fact, up to half of this power is spending in cooling of facilities (computer room air condition (CRAC) or computer room air handler (CRAH) in a data center. As energy consumption is huge the energy efficiency is an important issue to consider in the data center. Computation fluid dynamics (CFD) can be very useful in order to provide detail information about the airflow behavior in the existing data center and simulating a data center before it is built. How to simulation needed to carry Out with Quality and trust. In this study, the real-world k-epsilon turbulent airflow model is used. The academic code ANSYS Icepak 15.0 is used to simulate the experimental values of the data center / Research Lab at Syracuse University. In this study, I studied the simulation with the boundary condition of the data center and comparing the temperature distribution with measured sensors which are located in different placed in data center room and in the next chapter verified temperature rack inlet distribution with the Ashrea envelope and in the following chapter the investigate the effect of the different supply temperature on performance parameters indices and analyses.
Mining web logs: applications and challenges

Web logs record the primary interaction of users with web pages in general and search engines in particular. There are two sources for such logs: user trails obtained from toolbars and query/click information obtained from search engines. In this talk we will address the task of mining this rich data to improve user experience on the web. We will illustrate a few applications, together with the modeling and algorithmic challenges that stem from these applications. We will also discuss the privacy issues that arise in this context.
Structure and expression of a novel gene family showing male germline specific expression in Drosophila melanogaster

We report the characterization of two novel genes of Drosophila melanogaster, named mst36Fa and mst36Fb. They define a novel gene family, showing identical time and tissue‐specificity limited to male germ cells where their transcription starts during meiotic prophase. These two genes encode for two slightly basic proteins highly homologous to each other and fairly rich in leucine and glutamic acid. Although strictly clustered, these genes utilize different promoter regions as revealed by examination of transgenic flies bearing mst36F‐promoter‐lacZ reporter constructs and by reverse transcription–polymerase chain reaction assays. Our data suggest that at least one gene (mst36Fa) of the cluster is under translational repression until spermiogenesis suggesting a putative role in the spermatides differentiation. The present study is aimed at the structural analysis of these genes.
Bone safety of long-term bisphosphonate treatment

SUMMARY Bisphosphonates (BPs) are widely used in osteoporosis and other bone diseases. Treatment of osteoporosis would, in many instances, involve continued use of BP for a number of years, so it is pertinent to examine skeletal consequences of long-term BP use. Through a non-systematic review of the literature, this commentary considers the reduction in bone turnover and retention in the skeleton with regard to the long-term safety of BP use. BPs normalize bone turnover rates within weeks and no further suppression is seen during long term use, documented up to 10 years. This indicates that the BP retained in bone does not augment or contribute to the pharmacological activity of newly administered BP. Therefore, pharmacologically, long term treatment is not different from short term treatment. Multiple studies have shown that reductions in bone turnover are associated with increased bone density, more homogeneous mineralization, and reduced fracture risk. The amount of BP retained in bone after 10 years of alendronate treatment was estimated at 75 mg per 2 kg mineral, using a pharmacokinetic model for a dose of 10 mg per day. This small fraction, which is unevenly distributed between cancellous and cortical bone, seems unlikely to change bone mechanical properties. Taken together, the known mechanism of action of potent BPs and the experience accrued from treating a large number of patients, including up to 10 years follow-up in controlled trials, have identified only beneficial BP effects on bone.
How well do pharmacists know their patients? A case report highlighting natural health product disclosure

Natural health products (NHPs), a broad category that includes vitamins, minerals, herbs, homeopathic remedies, traditional medicines, probiotics, amino acids and fatty acids, are used to maintain and promote health, as well as to prevent or treat illness.1 Many consumers report using NHPs because they are perceived to be healthier or safer than conventional drugs.2 A Health Canada survey found that 73% of Canadians have reported using at least 1 NHP, and 20% believe NHPs are without adverse effects.2 As NHPs are available without a prescription, patients often use them to treat their medical conditions, based on advice obtained from the Internet, media sources and/or friends/family.3 Patients also do not consistently disclose NHP use to health care providers, nor are they routinely asked about such use.4-6 This lack of communication may have serious implications; for example, some NHPs, such as kava, have been associated with hepatotoxicity,7 and St. John’s wort may interact with a number of prescription medicines that may lead to failed therapeutic outcomes or increased risk of toxicity.8 Use of these products without health professional input could be inappropriate or lead to delayed recognition of adverse reactions if they occur. Community Pharmacy SONAR (Study Of Natural health product Adverse Reactions) is a multicentre study investigating adverse events (AEs) associated with the use of prescription drugs, NHPs and their concurrent use through the implementation of active surveillance. Consenting patients who reported an AE while also taking an NHP (both alone or concurrently with prescription drugs) were contacted by a research pharmacist (CN) to collect a detailed medical history. Detailed methods are available elsewhere.9 This study was approved by the Human Research Ethics Board at the University of Alberta. Here, we present a detailed case history of a SONAR study participant. The patient’s medication history is presented in a stepwise fashion to illustrate what can be learned when a pharmacist further questions a patient about NHP use—the initial information available is typical of routine pharmacy practice; the subsequent additive information can be learned when additional details are sought by the pharmacist.
Rigid model and flexible model of a novel stick-slip driving stage

In this paper, rigid model and flexible model of a novel stick-slip driving stage was proposed. In the building of rigid and flexible model of a novel stick-slip driving system, LuGre friction model was selected which is most suitable for the stick-slip driving. Combined with LuGre model, the rigid model of stick-slip driving was built and simulated in Simulink software. Combined with LuGre model and dynamics model of flexible hinge, the flexible model of stick-slip system was built and simulated in Simulink software. The displacement, speed and acceleration curve of the PZT, inertial mass and slider were obtained. Experiment prototype and the testing of stick-slip driving system were also designed. The actual displacement curve of different direction of the slider and the step displacement curve of the PZT were tested and the problem of different direction with different displacement was found. In order to better compare testing results and simulation results, simulation results and testing results were processed to show in a figure. The simulation results are validated by the testing results. Therefore, the rigid and flexible model is suitable to study the novel stick-slip stage and a kind of problem in stick-slip driving.
Neutrons do not produce a bystander effect in zebrafish irradiated in vivo

Abstract Purpose: Neutron irradiations at the McMaster Tandetron Accelerator were performed to study direct and bystander effects of neutrons in a live organism. Methods: The neutrons were produced through 7Li(p,n)7Be reaction. Although the gamma contamination of the neutron beam cannot be completely eliminated, it was designed to be as low as possible and remain below a threshold already established for bystander effects. Microdosimetric methods using a tissue-equivalent proportional counter have been used to measure the neutron and gamma doses for the cell irradiation. Previous data for a cell line exposed in vitro suggested that neutrons did not produce bystander effects at doses below 300 mGy. The current experiments sought to confirm this using a live whole organism (zebrafish) where tissue samples harvested 2 h after exposure were examined for direct evidence of apoptosis and tested for secretion of bystander factors using an established bioassay. Fish were either exposed directly to the beam or were allowed to swim with or in water previously occupied by irradiated fish. Results: Using the zebrafish model it was found that there was significant direct cell death seen both by apoptosis scores and clonogenic assay when the neutron dose was approximately 100 mGy. An equivalent dose of gamma rays produced a more toxic effect. It was further found that neutrons did not induce a bystander effect in fish receiving signals from irradiated fish. Conclusion: The results confirm in vitro experiments which suggest neutrons do not induce bystander signaling. In fact they may suppress gamma induced signaling suggesting a possible intriguing new and as yet unclear mechanism.
A further discussion on fuzzy interval cooperative games

The F-core and the F-balancedness have been introduced for fuzzy interval cooperative games by Mallozzi et al. (2011). It was pointed out that the F-balancedness was a necessary but not sufficient condition for the non-emptiness of the F-core. In this paper, a numerical example is given to show that the F-balancedness can not guarantee the non-emptiness of the F-core. Furthermore, the F-cores of trapezoidal fuzzy interval games are discussed in detail. Some properties of the F-core are obtained and three sufficient conditions for the non-emptiness of the F-core are given. These conclusions are generalizations of the corresponding results in both interval cooperative game theory and classical cooperative game theory. Lastly, an application example is also provided.
Are staff reliable informants? Identifying the triggers to challenging behaviours in dementia

There are increasing concerns about the use of neuropletics in the treatment of challenging behaviours. Their use has been associated with cerebro-vascular events, falls, weight gain, accelerated cognitive decline, while showing limited evidence of efﬁcacy (Sink et al ., 2005). In the light of such concerns, Howard and colleagues’ (2001) guidelines suggest that non-pharmacological interventions should be used prior to the use of pharmacological treatments. Turner (2005) argues that effective non-pharmacological interventions, for individuals displaying challenging behaviour, should be based on a multifaceted approach to assessment. She suggests that one employs applied behaviour analytic techniques within clinical formulations, such as conducting a functional analysis of people’s challenging behaviour. Aclinical objective when investigating the nature of challenging
Lens lactate dehydrogenase inactivation after UV-B irradiation: an in vivo measure of UVR-B penetration.

PURPOSE To elucidate the spatial distribution of inactivation of lactate dehydrogenase (LDH) in ultraviolet-B radiation (UVR-B)-exposed eyes. To determine the in vivo penetration depth of UVR-B in the lens. METHODS LDH activity in cornea and lens was investigated with an enzyme histochemical technique. Thirty rats were exposed in vivo to UVR-B of approximately 300 nm, and the eyes were enucleated and frozen at 0, 2, and 6 hours after exposure. LDH activity in frozen sections was determined quantitatively in the corneal epithelium and four different regions in the lens. UVR-B penetration depth was estimated by using a calculated Lambertian absorption coefficient. RESULTS The LDH activity was decreased in the cornea and the outer anterior lens cortex at all three time points. The average decrease in enzyme activity in the time range was 35% in the cornea and 20% in the outer anterior lens cortex. UVR-B inhibition of LDH was immediate and not dependent on an inflammatory reaction within the eye. Penetration depth, corresponding to 1/e(2) ( approximately 14%) residual UVR-B intensity, was 0.45 mm. CONCLUSIONS UVR-B does not exhibit any significant effect on LDH activity in the major part of the lens, and this is attributed to the shallow penetration (0.45 mm) of UVR-B into the anterior parts of the lens.