Miracle-dz/UniFAR-FTUs huggingface dataset:
Central site of the hypertensive action of bradykinin.

The intraventricular injection of 1 mug of bradykinin (BK) in rats anesthetized with urethane (1.5 g/kg i.p.) caused an increase in mean arterial blood pressure with little or no change in pulse pressure or heart rate. A similar hypertensive response followed the local administration of 0.5 mug of BK at the pars ventralis of the lateral septal area, whereas local application at other subcortical regions, known to be involved in cardiovascular regulation, caused no effect. Injections of 0.5 or 1 mug of synthetic substance P or 1 mug of 9-desarginine-bradykinin at the pars ventralis of the lateral septal area caused no change in blood pressure. In addition, bilateral electrolytical lesions placed in the lateral septal area either markedly reduced or completely blocked the pressor response to intraventricular BK. These results suggest that the pars ventralis of the lateral septal area is involved in the pressor action of BK in the central nervous system. They also indicate that this brain region responds fairly specifically to BK and that local vascular changes are unlikely to be involved in the mediation of the central action of BK.
Pax6; A pleiotropic player in development

Pax6 is a transcription factor essential for the development of tissues including the eyes, central nervous system and endocrine glands of vertebrates and invertebrates. It regulates the expression of a broad range of molecules, including transcription factors, cell adhesion and short‐range cell–cell signalling molecules, hormones and structural proteins. It has been implicated in a number of key biological processes including cell proliferation, migration, adhesion and signalling both in normal development and in oncogenesis. The mechanisms by which Pax6 regulates its downstream targets likely involve the use of different splice variants and interactions with multiple proteins, allowing it to generate different effects in different cells. Extrapolation to developmental transcription factors in general suggests that variation in the nature of individual factors is likely to contribute to the emergence of differences between tissues. BioEssays 24:1041–1051, 2002. © 2002 Wiley‐Periodicals, Inc.
Vitamin B12, Folate, Homocysteine and Urinary Methylmalonic Acid Levels in Infants

Serum vitamin B12 and folate, and their functional markers, plasma homocysteine and urinary methylmalonate (uMMA) were measured in 204 healthy, term infants at birth, and at 2 and 6 months. Compared with infants receiving formula food, those fed mother's milk had lower vitamin B12 and folate at 2 and 6 months. In infants receiving mother's milk, vitamin B12 levels were similar at birth (238 pg/ml) and 2 months (243 pg/ml), whereas with formula milk the level was significantly higher at 2 months (558 pg/ml) than at birth (257 pg/ml). Vitamin B12 was negatively correlated with homocysteine at birth and 6 months. The level of uMMA (mmol/mol creatinine) was higher at 2 (mother's milk, 25.5; formula, 23.97) and 6 months (19.77; 15) than at birth (11.97; 10.88), and was not correlated with vitamin B12 levels. Homocysteine may be a reliable marker of vitamin B12 status in neonates and infants; however, uMMA is not suitable as a marker of vitamin B12 status.
Restriction of Metabolizable Energy in Broiler Growers and Its Impact on Grower and Breeder Performance

Metabolizable energy (ME) required for basal metabolism, activity and growth was considered as the criterion for targeting specific increases in body weight (100 g/week) of broiler chicks during the grower phase (5-20 weeks) and its impact was evaluated on breeder performance. Broiler female chicks (460) from a synthetic dam line were randomly distributed to 4 test groups with 23 replicates of 5 birds each and housed in cages. The first group (ME-100) was offered a calculated amount of ME by providing a measured quantity of grower diet (160 g protein and 2,600 kcal ME/kg) which increased with age and weight gain (133-294 kcal/bird/day). The other three groups were offered 10 or 20% less ME (ME-90 and ME-80, respectively) and 10% excess ME (ME-110) over the control group (ME-100). From 21 weeks of age, a single breeder diet (170 g protein and 2,600 kcal ME/kg) was uniformly fed to all groups and the impact of grower ME restriction on breeder performance evaluated up to 58 weeks. The targeted body weight gain of 1,600 g in a 16-week period was achieved by pullets of the ME-100 group almost one week earlier by gaining 8.7 g more weight per week. However, pullets in the ME-90 group gained 1,571 g during the same period, which was closer to the targeted weight. At 20 weeks of age, the conversion efficiency of feed (5.21-5.37), ME (13.9-14.1 kcal/g weight gain) and protein (0.847-0.871 g/g weight gain), eviscerated meat yield, giblet and tibia weights were not influenced by ME restriction, but the weights of abdominal fat and liver were higher with increased ME intake. Reduction of ME by 10% in the grower period significantly delayed sexual maturity (169.3 d), but increased egg production (152.5 /bird) with better persistency. Improved conversion efficiency of feed, ME and protein per g egg content were also observed in this group up to 56 weeks. The fertility and hatchability at 58 weeks of age were higher in the ME-90 group compared to the control and 10% excess ME feeding. In conclusion, the present study revealed the possibility of achieving targeted weight gain in broiler growers by feeding measured quantities of ME during the rearing period with consequential benefits in breeder performance.
A phase‐sensitive method of flip angle mapping

A radiofrequency (RF) excitation scheme is presented in which flip angle is encoded in the phase of the resulting excitation. This excitation is implemented with nonselective hard pulses, and is used to give flip angle maps over three‐dimensional volumes. This phase‐sensitive B1 mapping excitation can be combined with various acquisition methods such as gradient recalled echo (GRE) and echo‐planar (EP) readouts. Imaging time depends primarily on the readout method, and is roughly equivalent to the imaging time of conventional double‐angle techniques for three‐dimensional acquisition. The phase‐sensitive method allows imaging over a much wider range of flip angles than double‐angle methods. Phantom and in vivo results are presented comparing the phase‐sensitive method with the conventional double‐angle method, demonstrating the ability of the phase‐sensitive method to measure a wider range of flip angles than double‐angle methods. Magn Reson Med 60:889–894, 2008. © 2008 Wiley‐Liss, Inc.
Antiepileptics for aggression and associated impulsivity.

BACKGROUND Aggression is a major public health issue and is integral to several mental health disorders. Antiepileptic drugs may reduce aggression by acting on the central nervous system to reduce neuronal hyper-excitability associated with aggression. OBJECTIVES To evaluate the efficacy of antiepileptic drugs in reducing aggression and associated impulsivity. SEARCH STRATEGY We searched CENTRAL, MEDLINE, EMBASE, CINAHL, PsycINFO, metaRegister of Controlled Trials (mRCT) and ClinicalTrials.gov to April 2009. We also searched Cochrane Schizophrenia Group's register of trials on aggression, National Research Record and handsearched for studies. SELECTION CRITERIA Prospective, placebo-controlled trials of antiepileptic drugs taken regularly by individuals with recurrent aggression to reduce the frequency or intensity of aggressive outbursts. DATA COLLECTION AND ANALYSIS Three authors independently selected studies and two authors independently extracted data. We calculated standardised mean differences (SMDs), with odds ratios (ORs) for dichotomous data. MAIN RESULTS Fourteen studies with data from 672 participants met the inclusion criteria. Five different antiepileptic drugs were examined. Sodium valproate/divalproex was superior to placebo for outpatient men with recurrent impulsive aggression, for impulsively aggressive adults with cluster B personality disorders, and for youths with conduct disorder, but not for children and adolescents with pervasive developmental disorder. Carbamazepine was superior to placebo in reducing acts of self-directed aggression in women with borderline personality disorder, but not in children with conduct disorder. Oxcarbazepine was superior to placebo for verbal aggression and aggression against objects in adult outpatients. Phenytoin was superior to placebo on the frequency of aggressive acts in male prisoners and in outpatient men including those with personality disorder, but not on the frequency of 'behavioral incidents' in delinquent boys. AUTHORS' CONCLUSIONS The authors consider that the body of evidence summarised in this review is insufficient to allow any firm conclusion to be drawn about the use of antiepileptic medication in the treatment of aggression and associated impulsivity. Four antiepileptics (valproate/divalproex, carbamazepine, oxcarbazepine and phenytoin) were effective, compared to placebo, in reducing aggression in at least one study, although for three drugs (valproate, carbamazepine and phenytoin) at least one other study showed no statistically significant difference between treatment and control conditions. Side effects were more commonly noted for the intervention group although adverse effects were not well reported. Absence of information does not necessarily mean that the treatment is safe, nor that the potential gains from the medication necessarily balance the risk of an adverse event occurring. Further research is needed.
Flow cytometric surface light chain analysis of lymphocyte‐rich effusions. A useful adjunct to cytologic diagnosis

The cytologic diagnoses in 49 body cavity fluids from 46 patients, of whom 30 had a clinical diagnosis of lymphoma or lymphatic leukemia, and 16 patients with benign inflammatory or reactive conditions, were compared to flow cytometric surface immunoglobulin light chain analysis (kappa‐lambda analysis [KLA]). The results of both tests were correlated with clinical outcome and all available information from biopsy, autopsy, and additional cell marker studies. When the diagnoses by both cytologic analysis and KLA were in agreement (57.1% of cases), there were no false‐negative or false‐positive results. Overall, false‐positive and false‐negative rates were, respectively, 6.1% and 12.2% with cytologic study, and 4.1% and 4.1% with KLA. Sixteen samples were from patients with small lymphocytic lymphoma (CLL) and small cleaved lymphoma, which had a false‐negative rate of 37.5% by cytologic study, and only 6.2% by KLA. There was one false‐positive result by KLA among the benign effusions. These findings indicate that KLA is a powerful adjunct to the cytologic evaluation of lymphocyte‐rich effusions, especially in cases of lymphoproliferative disorders characterized by small lymphocytes, in which the cytologic diagnosis is frequently difficult.
Dynamic Changes in the Transcriptome and Methylome of Chlamydomonas reinhardtii throughout Its Life Cycle1

Secretory and alga-specific genes are induced during gamete and zygote development in Chlamydomonas reinhardtii, concurrent with a dramatic increase in chloroplast cytosine methylation. The green alga Chlamydomonas reinhardtii undergoes gametogenesis and mating upon nitrogen starvation. While the steps involved in its sexual reproductive cycle have been extensively characterized, the genome-wide transcriptional and epigenetic changes underlying different life cycle stages have yet to be fully described. Here, we performed transcriptome and methylome sequencing to quantify expression and DNA methylation from vegetative and gametic cells of each mating type and from zygotes. We identified 361 gametic genes with mating type-specific expression patterns and 627 genes that are specifically induced in zygotes; furthermore, these sex-related gene sets were enriched for secretory pathway and alga-specific genes. We also examined the C. reinhardtii nuclear methylation map with base-level resolution at different life cycle stages. Despite having low global levels of nuclear methylation, we detected 23 hypermethylated loci in gene-poor, repeat-rich regions. We observed mating type-specific differences in chloroplast DNA methylation levels in plus versus minus mating type gametes followed by chloroplast DNA hypermethylation in zygotes. Lastly, we examined the expression of candidate DNA methyltransferases and found three, DMT1a, DMT1b, and DMT4, that are differentially expressed during the life cycle and are candidate DNA methylases. The expression and methylation data we present provide insight into cell type-specific transcriptional and epigenetic programs during key stages of the C. reinhardtii life cycle.
Frequency synchronisation using SS technique

Timing synchronisation is achieved by time (T)-division spread spectrum (SS) code acquisition. Frequency (F)-domain SS code acquisition method is proposed for the recently proposed F-division SS system (FD/S3), which uses T-domain correlation and permits frequency offset. Frequency dual of this method gives a new T-domain code acquisition with F-domain correlation, which is more resistant to frequency offset than the conventional one with T-domain correlation.
The neural correlate of very‐long‐term picture priming

Repetition priming denotes a behavioural change caused by prior exposure to a stimulus. The effect is known to last for weeks. This study addresses the underlying neural mechanisms for very‐long‐term picture priming by using event‐related functional magnetic resonance imaging complemented by a behavioural paradigm. Previous functional imaging studies with shorter retention intervals have shown that priming is associated with changes in the activity of both the occipital and posterior temporal cortex. In this study we compared retention intervals of 1 day and 6 weeks after initial exposure to a picture stimulus. Priming‐related decreases in cortical activity in posterior extrastriate and dorsal left inferior frontal areas were found only for the shorter retention interval. In contrast, fMRI activation in the inferior posterior temporal and anterior left inferior frontal cortex was reduced following priming for both retention intervals. In the behavioural paradigm, the priming effect was stable over time. We conclude that the left inferior frontal and inferior posterior temporal cortex play a key role in the very‐long‐term priming effect.
A 10-gb/s CMOS clock and data recovery circuit with an analog phase interpolator

This paper presents a 10-Gb/s clock and data recovery (CDR) circuit for use in multichannel applications. The module aligns the phase of a plesiochronous system clock to the incoming data by use of phase interpolation. Thus, coupling between voltage-controlled oscillators (VCOs) in adjacent channels can be avoided. The controller for the phase interpolator is realized with analog circuitry to overcome the speed and phase resolution limitations of digital implementations. Fabricated in a 0.11-/spl mu/m CMOS technology the module has a size of 0.25/spl times/1.4 mm/sup 2/. The power consumption is 220 mW from a supply voltage of 1.5 V. The CDR exceeds the SDH/SONET jitter tolerance specifications with a pseudo random bit sequence of length 2/sup 23/-1 and a bit-error rate threshold of 10/sup -12/. The re-timed and demultiplexed data has an rms jitter of 3.2 ps at a data rate of 2.7 Gb/s.
Patients' satisfaction with dental esthetics.

BACKGROUND Esthetics has become an important issue in modern society, as it seems to define one's character. In the past, functional demands were the main consideration in dental treatment. Today, with the decrease in caries prevalence, the focus has shifted toward dental esthetics. The authors conducted a study to evaluate the factors influencing patients' satisfaction with their dental appearance and with the results of esthetic treatment. METHODS The authors surveyed a population of 407 adults (mean age, 21 years). They distributed a questionnaire regarding satisfaction with current dental esthetics and previous esthetic treatments. RESULTS Of the 407 subjects, 152 (37.3 percent) were dissatisfied with their dental appearance. Tooth color was the primary reason for dissatisfaction (133 [89.3 percent] of 149 subjects), followed by poor tooth alignment (36 [23.7 percent] of 152 subjects), although 110 (27 percent) of the 407 subjects had received orthodontic treatment. The authors found no correlation between patients' satisfaction with their dental appearance and having undergone any procedure to whiten their teeth. Nevertheless, 134 (88.2 percent) of the dissatisfied subjects reported that they would like to undergo this procedure. CONCLUSIONS Tooth color was a major factor with regard to dental esthetics. Most subjects were interested in improving their appearance and whitening their teeth. CLINICAL IMPLICATIONS When planning treatment, dentists should take into consideration esthetic objectives in addition to function, structure and biology. This requires the clinician to rely on several disciplines in dentistry to deliver the highest level of dental care, which should lead to a higher level of patient satisfaction.
Effect of Insulin on the Materno-Fetal Transfer of Glucose in the Rat

Summary glycogen is increased with insulin, whereas it is de-14C glucose incorporation, as studied in 20 1/2 and 21 1/2 pressed by anti-insulin serum injections. Conversely day old rat fetuses after a glucose 14C injection into the mother, to these fmdings, Clark, Cahill and Soeldner (1968), is increased by insulin whereas it is depressed by anti-insulin and Felix Sulter Sulter and Jacquot (1971) con-serum.injection into the.fetu~ The . d~ta suggest that rat I d d ith . ' sul' . sensitivity of fetal tissues. fetal hssues are already msulin sensItive at the end of the C u e w an m m m gestation and that fetal insulin itself plays a role in the con trol of materno-fetal transfer of glucose.
PITCH ESTIMATION BASED ON WAVELET TRANSFORM FOR MUSIC THERAPY

Music is widely used for various purposes, it contributes to the treatment of patients since people appreciate it and use it for music therapy. Music therapy is a clinical practice that engages both client and therapist in dynamic musical interaction. In music pitch estimation experiments, the database is adopting western classical music and the original songs. We proposed a multiresolution feature extraction technique to deal with music therapy signals. We utilize adaptive resonance theory to search their clusters of features. The effectiveness of the clusters is encouraging.
Implementation of adaptive hysteresis current control technique for shunt active power conditioner and its comparison with conventional hysteresis current control technique

Poor power quality is the main issue in the present day electrical power supply system. The main cause of poor power quality is distortion and interruption in the natural form of power. Electrical drives, switching of semiconductor devices etc. result in severe voltage fluctuation, noisy operation of machine and un-necessary losses in transmission lines. In this paper, power quality issues and the possible solution are reviewed. Shunt active power filter with different reference current generation techniques and current control techniques is presented. Mathematical analysis and hardware implementation of Adaptive hysteresis current control is presented. Comparative analysis between fixed band hysteresis current control and adaptive hysteresis current control is given in tabular form.
Advances in Brief The NOD 2 3020 insC Mutation and the Risk of Colorectal Cancer

Several predispositions to colorectal cancer have been identified, but little is known about genetic susceptibilities to disease in older persons. Colorectal cancer is a risk in Crohn’s disease and is believed to be associated with an inappropriate inflammatory response. Recently, the NOD2 gene has been associated with Crohn’s disease, which further strengthens the notion that the inflammatory response plays a crucial role in this disease. Several mutations have been identified in the NOD2 gene, which appear with significantly higher frequency in patients with the disease. One such mutation (3020insC) is believed to be clearly causative because it results in a prematurely truncated protein with a predicted reduction in functional efficiency. In this report, we have examined the frequency of the 3020insC mutation in a series of 856 individuals including 556 patients with colorectal cancer. The frequency of the 3020insC mutation in a consecutive series of 250 non-hereditary nonpolyposis colorectal cancer patients>50 years of age was significantly elevated compared with the control population (odds ratio, 2.23; P 0.0046). The results indicate that NOD2 may be a predisposing factor to colorectal cancer characterized by an older average age of disease onset in persons who do not harbor any other genetic predisposition to disease.
Nerve and Behavioral Responses of Mice to Various Umami Substances

Food contains various taste substances. Among them, umami substances play an important role with regard to the perception of the taste of food, but, few studies have examined the taste characteristics of representative umami substances other than monosodium L-glutamate (MSG). By conducting mouse behavioral studies (the 48-h 2-bottle preference test and the conditioned taste aversion test) and assessing gustatory nerve responses, we investigated the taste characteristics of unique umami substances, including sodium succinate, L-theanine, betaine, and the enantiomer of MSG, D-MSG. Furthermore, we examined the synergy of umami with inosine 5′-monophoshate (IMP). In the case of the mice, sodium succinate had an umami taste and showed strong synergy with IMP. L-Theanine showed synergy with IMP but did not have an umami taste without IMP. In contrast, betaine did not have an umami taste or synergy with IMP. D-MSG might have weak synergy with IMP.
Correlation between soluble endoglin, vascular endothelial growth factor receptor-1, and adipocytokines in preeclampsia.

CONTEXT Recent reports have demonstrated that soluble endoglin (sEng), an antiangiogenic protein thought to impair TGF-beta binding to receptors, and soluble vascular endothelial growth factor receptor (sVEGFR)-1 play important roles in the pathophysiology of preeclampsia (PE). Moreover, insulin resistance, which is greatly influenced by adipocytokines, characterizes PE. OBJECTIVES We examined possible links between sEng, VEGF, sVEGFR, and adipocytokines in the pathophysiology of PE. STUDY DESIGN We performed a cross-sectional study in 30 PE patients and controls matched for gestational age and body mass index. Blood samples were collected soon after disease onset. We measured serum concentrations of leptin, adiponectin, sEng, VEGF, placental growth factor (PlGF), and sVEGFR [soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble fetal liver kinase 1 (sFlk-1)], and examined the placental protein content of sEng and sFlt-1. RESULTS sEng concentrations in PE patients (60.9 +/- 28.8 ng/ml) were significantly higher than those in controls (11.2 +/- 4.4 ng/ml). There was a significant correlation between sEng and sFlt-1 or PlGF. Moreover, there were significant differences in mean blood pressure between the high and low sEng groups, and in proteinuria between the high and low sFlt-1 groups, and significant differences in placental sEng and sFlt-1 contents between patients with and without severe hypertension or proteinuria. sEng was also correlated positively with adiponectin levels and negatively with the leptin to adiponectin ratio. CONCLUSIONS Along with sFlt-1 and PlGF, sEng might play a role in the pathophysiology of PE, especially in elevating blood pressure, while the association with hypoadiponectinemia and the high leptin to adiponectin ratio in pregnancy seem to be risk factors for PE.