Miracle-dz/UniFAR-FTUs huggingface dataset:
Haematology and plasma biochemistry reference intervals for the critically endangered western Santa Cruz Galapagos tortoise (Chelonoidis porteri)

Abstract Reference intervals (RIs) are an increasingly valuable tool for monitoring captive and free-living wildlife populations. Galapagos tortoises are one of the most emblematic species on Earth with 9 of the 12 extant species considered endangered due to human activities. As part of a long-term health assessment within the Galapagos Tortoise Movement Ecology Programme, we sampled a total of 210 free-living Santa Cruz Galapagos tortoises (Chelonoidis porteri). We collected blood from the brachial vein and performed packed cell volume (PCV), total solids (TS), morphological evaluation, white blood cell (WBC) count estimates and differentials and a VetScan biochemistry panel for each individual. We calculated 95% RIs and 90% confidence intervals (CIs) using the Reference Value Advisor tool and following international standard guidelines. Tortoises were categorized by estimated age and sex, with RI and CI reported here for 164 adult tortoises and 46 sub-adult tortoises. We found significant differences between sexes, with adult females presenting a lower PCV and higher values for both calcium and potassium. Among age groups, adult tortoises presented higher PCV, TS and albumin and lower WBC counts, aspartate aminotransferase and creatine kinase than sub-adult tortoises. We also found that tortoises presented higher numbers of lymphocytes during the dry season, but higher basophils, eosinophils, phosphorus, potassium and TS during the humid season. The heterophil:lymphocyte ratio did not differ between groups. To the authors’ knowledge, this is the first report of formal plasma biochemistry and haematology RI for free-living Galapagos tortoises. With the present study we provide an important diagnostic tool for captive-breeding programs in the Galapagos and zoological institutions globally that care for giant tortoises. The ultimate goal of this study is to contribute to the understanding of giant tortoise baseline health parameters and to inform local management decisions that help to conserve these emblematic species.
Anthyllis apennina (Fabaceae), a new species from central Apennine (Italy)

Abstract A new species of Anthyllis endemic to central Apennine growing in dry pastures on limestone in the montane belt, within Abruzzo and Lazio administrative regions (central Italy), is here described and illustrated and the IUCN assessment is proposed. This new species belongs to the morphologically very variable Anthyllis vulneraria species complex and it is close to A. pulchella (south-eastern Europe and Caucasus), but it can be clearly distinguished by its smaller flowers, mainly light yellow-coloured, bracts longer than flowers, calyx pink-coloured (usually only at apex) and size of cauline leaves and leaflets. Furthermore, the name A. pulchella is here lectotypified, by a second-step typification, on a specimen preserved at PAD.
What Motivates People to Start a Graduate Entry Nursing Programme: An Interpretive Multi-Centred Case Study

Introduction While graduate entry nursing programmes are well established in the United Kingdom and the United States of America (USA), they are relatively new to New Zealand and Australia. These programmes have been developed to meet the demands of the health workforce and provide graduates an alternative pathway to becoming a RN. Nursing is viewed as an attractive career option for this growing market of graduate entry students. Objective This study explored the motivations underpinning students choosing a graduate entry MNSc degree over a traditional undergraduate nursing programme. Methods A qualitative, longitudinal single case study design, informed by Yin was used. The first phase of the study is reported here. All students commencing a MNSc degree at the beginning of 2020 across four education providers (3 in New Zealand & 1 in Australia) were eligible to take part in the study. Ten students agreed to take part and undertake an interview. Braun and Clarke’s approach to thematic analysis was used to analyse the interview data. Results Three key themes of motivation were identified from the data: the attraction of nursing; the clarity nursing offers in terms of career progression; and the design of the intensive programme. Conclusions The motivations to choose a MNSc degree were deeply considered, multifaceted, and influenced by nursing role models. Students wanting to engage with a graduate entry MNSc programme did so through a reflective process of assessing their current career status and future career values. Participants in this study believed nursing would provide a secure and sustainable career path, potentially creating new horizons or possibilities beyond their previous work and life experiences. Having insight into what motivates individuals to enrol in such programmes may assist both education providers and the health sector with RN graduate recruitment and graduate entry programme enrolment.
Etude biologique et écotoxicologique de la chlorophycée Hydrodictyon reticulatum (L. ) Lagerh. , génératrice d'une fleur d'eau : site électronucléaire de Cattenom, Moselle, cycle biologique, constitution biochimique, capacité d'adsorption du cuivre : étude in situ et en laboratoire

Le reservoir du Mirgenbach (vol : 7,3 Mm3, surface : 90 ha, profondeur moyenne: 7,7 rn) constitue une source d'eau de securite et un milieu tampon pour la centrale electronucleaire de Cattenom (France - Region Est). Les eaux presentant une temperature, une conductivite, une durete et une capacite d'eutrophisation plus elevees que celles de la Moselle, ont ete le siege de fleurs d'eau a Hydrodictyon reticulatum (L. ) Lager. De 1987 a 1990. Pour parer aux risques de colmatage des ouvrages de prise et de rejet d'eau, l'extraction mecanique de la biomasse al gale a ete decidee. Au regard du niveau d'eutrophisation et de la quantite importante de biomasse produite, l'exploitation industrielle des algues et leur valorisation ont ete envisagees. A ce titre, une etude biologique et ecotoxicologique (cycle biologique, composition biochimique, capacite d'adsorption des micropolluants metalliques, toxicite du cuivre) a ete realisee in situ et en laboratoire. Les resultats analytiques de la composition biochimique (bonne teneur en proteines, diversite et richesse en elements mineraux, apports interessants en precurseurs vitaminiques), font de la biomasse d'Hydrodictyon reticulatum une excellente source de complement nutritionnel en tant qu'additif de rations alimentaires anim~es. Une autre voie envisagee est l'utilisation des pigments plastidiaux dans le domaine de la cosmetologie et de la parapharmacie. L'analyse minerale met en evidence de fortes capacites bioaccumulatrices des micropolluants metalliques tels que fer, cuivre, manganese et zinc. Les composes polyosidiques parietaux riches en acides uroniques, impliques dans la capacite d'adsorption presentent une grande affinite pour le cuivre et procurent aux algues une bonne resistance vis a vis de la toxicite du cuivre. L'utilisation d'Hydrodictyon reticulatum dans des procedes d'epuration est proposee
Electrospun dual phase Li4Ti5O12-TiO2/C nanocomposites as anodes for high-rate lithium-ion batteries

ABSTRACT Dual phase Li4Ti5O12-TiO2/C nanocomposites have been one-step synthesized by the method of electrospinning. When the Li4Ti5O12-TiO2/C nanocomposites are used as anode material for lithium-ion batteries, it exhibits excellent capacity of 186.5 mAh/g at 4000 mA/g with a good cycling performance. Simultaneously, it owns remarkable rate capability and reversible capability. The introduction of TiO2 enhances both the electric conductivity and the lithium ion diffusivity in Li4Ti5O12. And then it has good electrochemical performance.
A scoping review of rebel nurse leadership: Descriptions, competences and stimulating/hindering factors

Abstract Aims To (1) give an overview of rebel nurse leadership by summarising descriptions of positive deviance, tempered radicals and healthcare rebels; (2) examine the competences of nurse rebel leadership; and (3) describe factors that stimulate or hinder the development of rebel nurse leadership. Background Research shows nurses have lower intention to leave their jobs when they can control their work practices, show leadership and provide the best care. However, organisational rules and regulations do not always fit the provision of good care, which challenges nurses to show leadership and deviate from the rules and regulations to benefit the patient. Three concepts describe this practice: positive deviance, healthcare rebels and tempered radicals. Design Scoping review using the Joanna Briggs Institute methodology and PRISMA‐ScR checklist. Methods Papers describing positive deviance, healthcare rebels and tempered radicals in nursing were identified by searching Scopus, CINAHL, PubMed and PsycINFO. After data extraction, these three concepts were analysed to study the content of descriptions and definitions, competences and stimulating and hindering factors. Results Of 2705 identified papers, 25 were included. The concept descriptions yielded three aspects: (1) positive deviance approach, (2) unconventional and non‐confirmative behaviour and (3) relevance of networks and relationships. The competences were the ability to: (1) collaborate in/outside the organisation, (2) gain and share expert (evidence‐based) knowledge, (3) critically reflect on working habits/problems in daily care and dare to challenge the status quo and (4) generate ideas to improve care. The factors that stimulate or hinder the development of rebel nurse leadership are as follows: (1) dialogue and reflection, (2) networking conditions and (3) the managers’ role. Conclusions Based on our analysis, we summarise the descriptions given of rebel nurse leadership, the mentioned competences and provide an overview of the factors that stimulate or hinder rebel nurse leadership. Relevance to clinical practice The descriptions produced in this review of rebel nurse leadership and the stimulating or hindering factors listed should help nurses and managers encourage rebel leadership.
Upregulation of signal transducer and activator of transcription 3 in dogs with chronic inflammatory enteropathies

Abstract Background In inflammatory bowel disease (IBD) in humans, phosphorylated signal transducer and activator of transcription 3 (pSTAT3) is upregulated in mucosal epithelial cells and correlates with clinical severity. Hypothesis/Objective To investigate the expression pattern of pSTAT3 in the mucosa of dogs with chronic inflammatory enteropathy (CIE) and explore correlations between its expression and clinical and histopathological severity scoring. Animals Twenty‐eight canine CIE patients grouped into food‐responsive enteropathy (FRE; 9), steroid‐responsive enteropathy (SRE; 10), and protein‐losing enteropathy (PLE; 9). Ten healthy beagle dogs served as controls (CO). Methods Retrospective case control study. Immunohistochemistry was used to detect pSTAT3 in canine duodenal mucosa samples. Results Compared to CO, SRE (P < .001) and PLE (P < .001) dogs had significantly higher pSTAT3 expression in the villus epithelium. The SRE group had a significantly higher expression in the villus lamina propria (VLP) compared to controls (P = .009). In the crypt epithelium (CE), all CIE dogs had significantly higher pSTAT3 expression (FRE, P = .002; SRE, P = .003; PLE, P < .001) compared to CO. In the lamina propria crypt region (CLP), dogs with FRE (P = .04) and SRE (P = .03) had significantly upregulated pSTAT3 compared to controls. A positive correlation was found between canine chronic enteropathy clinical activity index (CCECAI) scoring and pSTAT3 expression for both epithelial (rho = .541; P < .001) and crypt regions (rho = .32; P = .02). Conclusions and Clinical Importance pSTAT3 is upregulated in CIE in dogs, correlates with clinical severity, and may be helpful as a clinical marker in dogs with CIE.
Electronic Tools to Bridge the Language Gap in Health Care for People Who Have Migrated: Systematic Review

Background People who have migrated or with a language barrier may face significant hurdles in accessing health care. Some apps have been specifically developed to facilitate the dialogue between health care professionals and people who have migrated who have low-level language proficiency or to promote health among people who have migrated. Objective We conducted a systematic review to investigate development, acceptability, and effectiveness of these types of apps. Methods We conducted a search of PubMed, Scopus, and Embase databases. We included all study designs (qualitative, quantitative, mixed) reporting development, evaluation of efficacy, or acceptability of apps facilitating dialogue with a health professional or promoting health for people who have migrated, minorities, or tourists with a language barrier, using any outcome. Two researchers selected the studies independently. We collected general information about the app, information about health literacy and cultural adaptation, information about the development of the app, evidence on acceptability or efficacy, and information on app use. Data were collected by 2 researchers independently and results were reviewed to verify agreement and reported according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-analysis). Results Positive results for translation apps included better communication, but with possible limitations, and reduced consultation time. Positive results for health promotion apps included improved quality of life and better management of chronic illnesses. Conclusions Overall, the apps had good levels of acceptability, though only half had their efficacy evaluated. In those evaluations, the endpoints were mostly related to reported behavior change and knowledge improvement, which is common for evaluations of health promotion programs. In the future, as more health apps are created, it is essential that apps that claim to have a public health objective undergo a rigorous evaluation of their acceptability, efficacy, and actual use. Indicators of outcomes beyond changes in behavior and knowledge should be reported; change in health status or access to care should also be reported. This systematic review has helped us note the characteristics associated with improved acceptability and efficacy, which can be helpful for the development of future apps.
Unified Analysis on the Global Dissipativity and Stability of Fractional-Order Multidimension-Valued Memristive Neural Networks With Time Delay

The unified criteria are analyzed on the global dissipativity and stability for the delayed fractional-order systems of multidimension-valued memristive neural networks (FSMVMNNs) in this article. First, based on the comprehensive knowledge about multidimensional algebra, fractional derivatives, and nonsmooth analysis, we establish the unified model for the studied FSMVMNNs in order to propose a more uniform method to analyze the dynamic behaviors of multidimensional neural networks. Then, by mainly applying the Lyapunov method, employing several new lemmas, and solving some mathematical difficulties, without any separation, we acquire the unified and concise criteria. The derived criteria have many advantages in a smaller calculation, lower conservatism, more diversity, and higher flexibility. Finally, we provide two numerical examples to express the availability and improvements of the theoretical results.
Selective Sweep at a QTL in a Randomly Fluctuating Environment

Adaptation is mediated by phenotypic traits that are often near continuous, and undergo selective pressures that may change with the environment. The dynamics of allelic frequencies at underlying quantitative trait loci (QTL) depend on their own phenotypic effects, but also possibly on other polymorphic loci affecting the same trait, and on environmental change driving phenotypic selection. Most environments include a substantial component of random noise, characterized both by its magnitude and its temporal autocorrelation, which sets the timescale of environmental predictability. I investigate the dynamics of a mutation affecting a quantitative trait in an autocorrelated stochastic environment that causes random fluctuations of an optimum phenotype. The trait under selection may also exhibit background polygenic variance caused by many polymorphic loci of small effects elsewhere in the genome. In addition, the mutation at the QTL may affect phenotypic plasticity, the phenotypic response of given genotype to its environment of development or expression. Stochastic environmental fluctuations increase the variance of the evolutionary process, with consequences for the probability of a complete sweep at the QTL. Background polygenic variation critically alters this process, by setting an upper limit to stochastic variance of population genetics at the QTL. For a plasticity QTL, stochastic fluctuations also influences the expected selection coefficient, and alleles with the same expected trajectory can have very different stochastic variances. Finally, a mutation may be favored through its effect on plasticity despite causing a systematic mismatch with optimum, which is compensated by evolution of the mean background phenotype.
Association between interleukin-1 alpha rs1800587 polymorphism and rheumatoid arthritis: A meta-analysis

No consistent results have been reached on the relationship of interleukin-1 (IL-1) rs1800587 polymorphism with the susceptibility to rheumatoid arthritis (RA) so far. Therefore, the current meta-analysis was designed to thoroughly review relevant studies, in order to examine the relationship of IL-1A rs1800587 polymorphism with RA risk. Electronic databases were retrieved for literature regarding the relationship between IL-1A rs1800587 polymorphism and RA vulnerability according to the inclusion and exclusion criteria. Stata 12.0 software was adopted to examine the enrolled literature. Meanwhile, odds ratio (OR) and corresponding 95% confidence intervals (95% CI) were used to evaluate the association. A total of seven case-control researches (3267 patients and 2960 healthy controls) were eventually enrolled into the current meta-analysis. Our data indicated no correlation of IL-1A rs1800587 polymorphism with RA risk (TT vs CC: OR = 0.90, 95% CI = 0.73–1.11; TC vs CC: OR = 1.02, 95% CI = 0.78–1.34; Dominant model: OR = 1.04, 95% CI = 0.80–1.35; Recessive model: OR = 1.91, 95% CI = 0.74–1.12). Similarly, no association was found in subgroup analysis stratified by ethnicity. Our findings indicated no relationship between IL-1A rs1800587 polymorphism and RA vulnerability.
A Case of Sheehan Syndrome 7 Years Postpartum with Transaminitis and Hyperlipidemia

Patient: Female, 46-year-old Final Diagnosis: Sheehan syndrome Symptoms: Fatigue • light-headedness Medication: — Clinical Procedure: — Specialty: Endocrinology and Metabolic Objective: Rare disease Background: Sheehan syndrome (pituitary necrosis after postpartum hemorrhage) can present in various ways, depending on the hormones that are deficient. There may be a long delay to diagnosis of over a decade because symptoms are often vague and pituitary dysfunction progresses gradually. We describe a case of a patient with acute presentation of Sheehan syndrome 7 years after the obstetric event and with no clear precipitating event. Case Report: A 46-year-old woman with a history of hyperlipidemia and transaminitis came to the clinic for evaluation of hypotension and syncope. She had a history of longstanding anhedonia, fatigue, and postpartum hemorrhage 7 years previously and had undergone medical evaluations with her primary doctor with no cause found. Laboratory results showed anemia, central hypothyroidism, and adrenal insufficiency. A diagnosis of Sheehan syndrome was made. Conclusions: Sheehan syndrome is a rare condition of progressive pituitary dysfunction, which can present with nonspecific symptoms and a myriad of laboratory abnormalities until an adrenal crisis is triggered years after the precipitating event. Screening patients for hypopituitarism by free thyroxine levels and adrenocorticotropic hormone (ACTH) stimulation testing is vital for determining whether hypopituitarism is the cause in the appropriate clinical scenario. Use of thyroid-stimulating hormone levels and morning cortisol testing alone will miss this diagnosis, and free thyroxine levels and ACTH stimulation testing are vital.
Criminal mutilation in Sweden from 1991 to 2017

We identified 43 cases of mutilation homicides in a nationwide population‐based study in Sweden during the period of 1991–2017. 70% of cases were classified as defensive mutilations where the main motive was disposal of the body, while 30% were classified as offensive, that is, due to an expression of strong aggression, necro‐/sexual sadism, or psychiatric illness. In comparison with a previous study covering mutilation homicides in Sweden between 1961 and 1990, we noted an increase in incidence. The percentage of cases involving mutilation had increased from 0.5% of all homicides in the 1960s to 2.4% in the 2010s. The most common cause of death was sharp force, but in 28% of the cases, the cause of death could not be determined. The clearance rate in cases of mutilation homicide was 67%, and in a large majority of the cases, the offender was known to the victim. With regards to gender women made up 44% of the victims, whilst men constituted 56% of the victims and a total of 95% of the offenders. Half of the offenders had a personality disorder, however, only 13% were sentenced to forensic psychiatric care.
Der tiefe sternale Wundinfekt nach Sternotomie

Zusammenfassung Der tiefe sternale Wundinfekt (TSWI) ist eine seltene Komplikation nach Sternotomie, die mit hoher Morbidität und Mortalität behaftet ist und Krankenhausaufenthalt sowie die Behandlungskosten signifikant ansteigen lässt. Eine mikrobiologische Besonderheit ist die Ausbildung von Biofilmen auf Implantatmaterial und/oder Knochensequestern. Die Diagnose wird anhand der klinischen Symptomatik der lokalen Entzündungsreaktion gestellt und durch systemische Infektionszeichen gestützt. Eine frühzeitige und gemeinsame Konsensfindung, welche die oft interdisziplinäre Behandlungsstrategie festlegt, ist dabei essenziell. Die Behandlung besteht i. d. R. aus mehreren chirurgischen Wunddebridements mit zwischenzeitlicher Wundkonditionierung, bis ein ausreichend sauberer Wundstatus erreicht ist. Zur Infektsanierung und für den Wundverschluss stehen je nach Größe und Lokalisation des Gewebedefektes eine Vielzahl verschiedener gestielter und freier Lappenplastiken zur Auswahl.