Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic analysis of surgical-pathologic N1 disease in non-small cell lung cancer: Single-center experience with 276 cases

OBJECTIVE: Patients who receive surgical treatment due to non-small cell lung cancer (NSCLC) and have surgical-pathologic N1 (pN1) disease represent a heterogeneous group. Differences in lymph node (LN) level (hilar or intrapulmonary LNs) may influence patient survival. The aim of this study was to evaluate the prognostic factors, including the level of N1 LN involvement. METHODS: Patients undergoing complete resection at a single center between January 2000 and January 2017 and diagnosed with surgical-pN1 NSCLC were analyzed retrospectively. Patients were examined in terms of demographic characteristics, preoperative and postoperative management, survival rates, as well as variables affecting survival. RESULTS: The mean follow-up duration was 50.9 ± 41.2 months (between 2.7 and 204 months); median and 5-year survival rates were 71.5 months and 53.7%, respectively. Five-year survival rates of patients aged 60 and below (n = 144) and patients over the age of 60 (n = 132) were 59.7% and 46.9%, respectively (P = 0.001). Five-year survival rates for patients receiving and not receiving adjuvant therapy were 58.4% and 45.3%, respectively (P = 0.02). When surgical-pN1 involvement was assessed with regard to localization, 5-year survival was 59.1% in hilar involvement, 52.4% in intrapulmonary involvement, and 49.4% in involvement of both zones at the same time (P = 0.58). In Cox regression analysis, variables affecting survival were age group and adjuvant therapy (P = 0.001 and P = 0.012, respectively). CONCLUSION: Surgical-pN1 localization or pleural involvement does not have a significant effect on survival, whereas advanced age and further T classification affect survival adversely. Adjuvant therapy, on the other hand, has a significantly positive effect on survival.
Preterm birth and the shape of the heart.

Preterm birth, that is, delivery >3 weeks before term, affects an estimated 13 000 000 newborn infants annually, and rates are increasing.1 In only the United States, ≈500 000 infants are born preterm each year, and of these, 80 000 are delivered very preterm (>8 weeks before the expected date). Without effective care, the number of deaths among very preterm infants would equal that of major causes of death in adults such as Alzheimer disease or essential hypertension. Although mortality after preterm birth was high until a few decades ago, advances in perinatal medicine have resulted in almost universal survival,2 so the concept of prematurity nowadays is shifting from a pregnancy complication to a common developmental basis for a whole new generation of young adults. Although this progress is very welcome for women delivering preterm, their infants, and their families, there is an increasing concern because preterm birth has been identified as an emerging risk factor for arterial hypertension,3–5 diabetes mellitus,6,7 cardiovascular disease,8 and stroke9 in later life. Article see p 197 Observational and …
Uso clínico de ivabradina

aHelmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai, Nueva York; bDivision of Cardiology, Icahn School of Medicine at Mount Sinai, Nueva York; y cPopulation Health Science and Policy, Icahn School of Medicine at Mount Sinai, Nueva York. El Dr. Pinney ha recibido pagos por consultoría de Abbott. Todos los demás autores no tienen ninguna relación que declarar que sea relevante respecto al contenido de este artículo. Roberto Ferrari, MD, PhD, fue Editor Invitado para este artículo.
Cerebrospinal and commissural diaschisis in acute stroke patients: case study

Актуальність. Інсульт залишається другою основною причиною інвалідності та смертності з найвищими показниками захворюваності та летальності в країнах Східної Європі порівняно з Західною Європою та США. Раннє відновлення неврологічних функцій після інсульту пов’язане з реорганізацією в моторних і премоторних ділянках кори головного мозку та пояснюється феноменом діашизу. Проте на сьогодні опубліковано недостатньо проспективних досліджень щодо клінічного аналізу та порівняння різних варіантів церебрального діашизу, особливо в пацієнтів iз гострим ішемічним інсультом. Мета дослідження: динамічний аналіз клінічних проявів цереброспінального та коміссурального варіантів церебрального діашизу в пацієнтів iз гострим ішемічним інсультом на основі презентації клінічних випадків. Матеріали та методи. Ми провели проспективне госпітальне когортне дослідження хворих на гострий інсульт (n = 124), якi надійшли до відділення цереброваскулярних захворювань Університетської лікарні (Олександрівська клінічна лікарня, м. Київ, Україна) протягом перших 24 годин після розвитку інсульту. Під час госпіталізації всі пацієнти пройшли комплексне клініко­неврологічне, лабораторне, ультразвукове та нейровізуалізаційне обстеження. Результати. Серед 124 обстежених iз гострим інсультом церебральний діашиз було діагностовано в 26 пацієнтів (цереброспінальний (n = 22) та комісуральний (n = 4)). Ми провели детальний клінічний аналіз проявів мозкового діашизу. Описано специфічні неврологічні зміни за територіальних інфарктів мозку та дзеркальних інсультів, викликаних діашизом. Висновки. Семіотика гострого церебрального інсульту визначається не тільки первинним інфарктом мозку, але й діашизом, що обумовлює більш серйозний неврологічний дефіцит. Церебральний діашиз пов’язаний з розвитком дзеркальних інфарктів мозку, пригніченням сухожилкових та періостальних рефлексів, атонією м’язів кінцівок.
Microbiology : A Clinical Approach

Give us 5 minutes and we will show you the best book to read today. This is it, the microbiology a clinical approach that will be your best choice for better reading book. Your five times will not spend wasted by reading this website. You can take the book as a source to make better concept. Referring the books that can be situated with your needs is sometime difficult. But here, this is so easy. You can find the best thing of book that you can read.
Facteurs épidémiologiques influençant la survie dans le lymphome à cellules du manteau

Le Lymphome a Cellules du Manteau (LCM) est une entite recemment identifiee qui se caracterise par la translocation genetique t(11 ;14)(q13 ;q32) et compte pour 2 a 10 % de tous les Lymphomes non-Hodgkiniens. Avec une survie mediane entre 3 et 5 ans apres le diagnostic, le LCM est une pathologie agressive et malgre les recentes avancees therapeutiques, peu d’informations sont disponibles concernant ses facteurs pronostiques. Certaines etudes ont analyse le role des caracteristiques clinicopathologiques et des nouvelles strategies therapeutiques, mais on connait peut le role des facteurs environnementaux et du mode de vie sur le pronostic des patients atteints de LCM. Entre 2008 et 2012, le groupe LYSA a mene en France deux essais cliniques prospectifs multicentriques : LM manteau 2010 SA "RiBVD" (NCI01457144) et Manteau 2007 SJ "LyMa" (NCT00921414). Apres une comparaison de ces patients avec les patients de population generale, l’effet de facteurs socioeconomiques et des habitudes de vie sur la survie des patients a ete etudie a l’aide d’un questionnaire qualitatif administre a tous les volontaires apres le diagnostic. Nos resultats suggerent qu’un faible niveau d’education, un indice de masse corporelle eleve et de la consommation d’alcool sont associes a un risque de deces plus eleve chez les patients atteints de LCM. Toutefois, l’etude de tels facteurs et de leur influence sur un sous-type de LNH aussi rare requiert des echantillons d’etude de taille plus importante. L’elargissement des criteres d’inclusion des patients dans les essais cliniques permettrait de selectionner davantage de patients mais aussi des patients mieux representatifs de la population generale. Enfin, l’integration systematique de ce type de questionnaire dans les protocoles d’essais cliniques serait aussi un atout majeur.
PATIENTS OF DISEASE AMONG HOSPITALIZED PATENTS WITH DENGUE INFECTION DURING 2016 OUTBREAK IN ENDEMIC AREA, INDONESIA

ABSTRACT Background : Dengue is an endemic vector borne disease in tropical and subtropical area, including Indonesia. Even several areas experienced dengue outbreak, with high number of cases. : The study was conducted to describe clinical and laboratory profile in hospitalized patient with dengue infections during 2016 outbreak in Banyumas Regency, Indonesia. Material and Method : A descriptive study was carried out in clinical and laboratory profile from Banyumas Regency Health Office data . 463 patient were included in this study due to the complete information. Results : Fever, limp and nausea were the major presenting symptoms of the patients. 59.6% of patients were without thrombocytopenia. DHF was the major cases among the patients with 84.55 % and most of them categorized as secondary infection (48.1%). Conclusion : Most of the patients during outbreak experienced a severe clinical manifestations, probably due to the secondary infection based on serology test. Key words : dengue, outbreak, clinical profile, laboratory
THE LINKAGE BETWEEN TRANSCRIPTION CONTROL AND EPIGENETIC REGULATION: THE SNAIL STORY AND BEYOND

OF DISSERTATION THE LINKAGE BETWEEN TRANSCRIPTION CONTROL AND EPIGENETIC REGULATION: THE SNAIL STORY AND BEYOND Epigenetic deregulation contributes significantly to the development of multiple human diseases, including cancer. While great effort has been made to elucidate the underlying mechanism, our knowledge on epigenetic regulation is still fragmentary, an important gap being how the diverse epigenetic events coordinate to control gene transcription. In the first part of our study, we demonstrated an important link between Snail-mediated transcriptional control and epigenetic regulation during cancer development. Specifically, we found that the highly conserved SNAG domain of Snail sequentially and structurally mimics the N-terminal tail of histone H3, thereby functions as a molecular “hook”, or pseudo substrate, for recruiting histone lysine specific demethylase 1 (LSD1) repressor complex to the E-cadherin promoter. Furthermore, we showed that Snail and LSD1 are both required for E-cadherin repression and EMT induction, and their expression is highly correlated with each other in multiple human tumor tissues. Our findings have important clinical ramifications in that compounds mimicking the SNAG domain may disrupt Snail-LSD1 interaction and inhibit EMT and metastasis. In the second part of our study, we designed a batch of compounds based on the structure of the SNAG domain and are currently screening for candidates capable of competing with SNAG peptide for LSD1 binding. In addition, we applied a peptide pulldown/mass spectrometry-coupled analysis to identify SNAG-interacting proteins, among which are many chromatin enzymes and modulators. Functional characterization of these proteins will help to elucidate the Snail-mediated epigenetic regulation process. In the third part of our study, we found that Snail interacts with poly(ADP-ribose) polymerase 1 (PARP1) through a potential pADPr-binding motif and is subject to poly(ADP-ribosyl)ation, which can stabilize the Snail-LSD1 complex for enhanced PTEN suppression under DNA damage condition. Our findings added another layer to the delicate Snail transcriptional machinery, and indicated that PARP inhibitors may be applied in combination with conventional chemotherapies to target cancers with high expression of Snail and LSD1. In summary, we demonstrated that Snail cooperates with multiple epigenetic machineries to induce EMT as well as survival of tumor cells. Our findings contribute to a better appreciation of Snail-mediated epigenetic network as well as diversification of therapeutic strategies against cancer.
Palliation of Painful Bone Metastases: The "Rizzoli" Experience

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Impacts of transitional palliative care for end-stage heart failure patients

Background: Heart failure (HF) is a chronic, progressive life-threatening illness. Along the illness trajectory, in particular approaching to end-stage, patients with HF suffer from significant physical and psycho-social-spiritual symptom burden, which are associated with increased hospital admissions and impaired quality of life (QOL) on these patients. Given that HF poses tremendous burden on patients, healthcare system, and society, the impact of HF can be reduced if effective management is implemented. Post discharge care coordination is still an unmet need for many patients with end-stage HF (ESHF), particularly when they are returned home from hospital after an acute exacerbation. Additionally, patients with ESHF seldom receive specialist palliative care (PC), while PC is considered appropriate for them. It is essential to develop a transitional PC intervention, which is a Home-based Palliative Heart Failure (HPHF) program, and test its effectiveness in order to build research evidence and to guide clinical practice.
Hypotension during spinal anaesthesia for Caesarean section in a resource-limited setting: towards a consensus definition

Background: Intraoperative hypotension following spinal anaesthesia for Caesarean section is associated with maternal morbidity and mortality. Because of inconsistent definitions the reported incidence of hypotension varies between 7% and 74%, making it almost impossible to set standard targets. Developing and adopting a clinically significant threshold for intraoperative hypotension will allow for benchmarking, comparison between studies, and consistency in guidelines and recommendations. Methods: Common definitions for spinal hypotension were first identified from a recent systematic review of the literature and a consensus statement on spinal hypotension. These definitions were applied to haemodynamic data taken from a prospective interventional obstetric spinal hypotension study conducted at Edendale Hospital, to determine the incidence of hypotension when applying these different thresholds. Finally, a definition was proposed based on these incidences and a review of the relevant literature. Results: Fifteen different definitions were identified. These were then applied to the study population with a resultant incidence of hypotension ranging from 15.8% to 91.4%. Based on a literature review of obstetric and other relevant perioperative and critical care medicine, targeting a mean arterial pressure > 70 mmHg and systolic blood pressure > 100 mmHg is recommended, and it is proposed that the lowest absolute values at which vasopressor therapy should be initiated are a mean arterial blood pressure < 65 mmHg or systolic blood pressure < 90 mmHg. Optimally, practitioners should maintain systolic blood pressure at greater than 90% of the baseline pre-spinal anaesthesia value. Conclusion: This study confirmed a wide variation in the incidence of obstetric spinal hypotension in a South African setting, depending on the definition used. An absolute threshold for intervention with vasopressor and an optimal target relative to baseline blood pressure are suggested. Further work is required to establish the effect of the adherence to these recommendations on important maternal and foetal outcomes.
Order Lepidoptera Linnaeus, 1758.

For the kingdom Animalia, 1,552,319 species have been described in 40 phyla in a new evolutionary classification. Among these, the phylum Arthropoda alone represents 1,242,040 species, or about 80% of the total. The most successful group, the Insecta (1,020,007 species), accounts for about 66% of all animals. The most successful insect order, Coleoptera (387,100 species), represents about 38% of all species in 39 insect orders. Another major group in Arthropoda is the class Arachnida (112,201 species), which is dominated by the mites and ticks (Acari 54,617 species) and spiders (43,579 species). Other highly diverse arthropod groups include Crustacea (66,914 species), Trilobitomorpha (19,606 species) and Myriapoda (11,885 species). The phylum Mollusca (117,358 species) is more diverse than other successful invertebrate phyla Platyhelminthes (29,285 species), Nematoda (24,783 species), Echinodermata (20,509 species), Annelida (17,210 species) and Bryozoa (10,941 species). The phylum Craniata, including the vertebrates, represents 64,832 species (for Recent taxa, except for amphibians): among these 7,694 described species of amphibians, 31,958 species of fish and 5,750 species of mammals.
Structural Characterization of Indian Vitrinite-Rich Bituminous Karharbari Coal

The detailed investigation of the chemical structure of vitrinite-rich Karharbari coal was performed utilizing advanced analytical techniques. The salient objective of this work is the evaluation of various structural properties of coal, which is necessary for identifying the chemical and physical interactions between coal and various reactants during its utilization. Karharbari coal is a poorly organized coal with high aromatic content. The value of corrected aromaticity (fa’) was found to be 0.82 by 13C NMR spectroscopy and was also confirmed by XRD (aromaticity = 0.84) and FT-IR analysis (aromaticity = 0.82). The average molecular weight of the aromatic cluster was found to be 507 amu by the NMR result, which is closer to the result obtained by HRTEM (MW = 530 amu). The structural and lattice parameters of Karharbari coal were obtained by NMR spectroscopy and then compared with the similar rank Argonne Premium coal. The molecular weight distribution was obtained by LD-TOF-MS and compared with HRTEM fringe model analysis. The presence of different heteroatoms like carbon, oxygen, nitrogen, and sulfur with their functionalities was determined by using the XPS technique. Different carbon/oxygen functionalities present in the Karharbari coal were found to be (C–C) and (C–H) 68.5%, (C–O) 23.4%, (COO–) 1.9%, and (C=O) 6.0%. Nitrogen functionalities such as pyridine, pyrrolic, quaternary, and oxidized nitrogen and their compositions (mol %) were 19.3, 45.6, 31.2, and 3.7%, respectively. Different forms of sulfur were also found to be present, namely, thiophenes, sulfones, sulfuric acid, and sulfates with the molar contents of 16.4, 41.6, 21.3, and 20.5%, respectively. This information will be useful in improvising coal utilization techniques.
Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms

Abstract Following a request from EFSA, the Panel on Plant Protection Products and their Residues (PPR) developed an opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) models and their use in prospective environmental risk assessment (ERA) for pesticides and aquatic organisms. TKTD models are species‐ and compound‐specific and can be used to predict (sub)lethal effects of pesticides under untested (time‐variable) exposure conditions. Three different types of TKTD models are described, viz., (i) the ‘General Unified Threshold models of Survival’ (GUTS), (ii) those based on the Dynamic Energy Budget theory (DEBtox models), and (iii) models for primary producers. All these TKTD models follow the principle that the processes influencing internal exposure of an organism, (TK), are separated from the processes that lead to damage and effects/mortality (TD). GUTS models can be used to predict survival rate under untested exposure conditions. DEBtox models explore the effects on growth and reproduction of toxicants over time, even over the entire life cycle. TKTD model for primary producers and pesticides have been developed for algae, Lemna and Myriophyllum. For all TKTD model calibration, both toxicity data on standard test species and/or additional species can be used. For validation, substance and species‐specific data sets from independent refined‐exposure experiments are required. Based on the current state of the art (e.g. lack of documented and evaluated examples), the DEBtox modelling approach is currently limited to research applications. However, its great potential for future use in prospective ERA for pesticides is recognised. The GUTS model and the Lemna model are considered ready to be used in risk assessment.