Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Trunk Rotation and Backrest Activity on Lumbar sEMG Activities, Body Pressure Distribution and Sitting Discomfort during Sitting

The purpose of this study was to examine the effects of trunk rotation and backrest activity on sitting discomfort, body pressure distribution and lumbar surface Electromyographic (sEMG) activities of lumbar erector spinae muscles (LES) and lumbar multifidus muscles (LMF), so as to provide a scientific basis on dynamic chair design and optimization and human-table-chair office system design. Ten healthy male subjects sat on two kinds of office chairs (one fixed dual-back chair and one movable dual-back chair), rotating 60° to the left and the right to simulate the common trunk activities of office work with the seatpan and backrest angle of 110°. Four tests were performed on each subject and sEMG activities of bilateral LES and LMF and body pressure distribution data of seatpan and backrest were statically measured. Meanwhile the Body Part Discomfort (BPD) Scale (Revised) was used to measure the subjective feelings of sitting discomfort. The results showed: (1) backrest activity did not affect marginally on LES and LMF myoelectric activities (P>.05) but trunk rotation had a significant effect on sEMG activities of left LMF (P<.01); (2) trunk rotation did not affect marginally on all the pressure variables (P>.05) but backrest activity affected marginally on average seatpan pressure (ASP), average backrest pressure (ABP) and peak backrest pressure (PBP) (P<.05); (3) low back discomfort (LBD) and total discomfort (OD) subjective ratings were significantly affected by backrest activity which had a large difference between fixed and movable dual-back chair and the latter gained a lower rating of discomfort. This study systematically utilized the combination of objective and subjective measurement to confirm that movable dual-back chairs were significantly better than fixed dual-back chairs which showed the superiority of dynamic chairs.
The Use of Multimodal Data to Augment Shallow-Water Benthic Habitat Maps for Pleasant Bay, Cape Cod, Massachusetts: Stratigraphic Data and Seafloor Maps

Abstract This paper discusses the utility of using seismic-reflection profiling and sediment cores in addition to bottom grab samples and acoustic data to develop shallow-water benthic habitat maps. Currently, the classification system used herein does not provide for the incorporation of stratigraphic data, but we believe that the utility of these maps would improve if such data were included. We conducted vessel-based seafloor-mapping surveys using a phase-measuring sidescan sonar in very shallow waters (mean depth = 3.2 m) covering an area >6.7 km2 in Pleasant Bay in 2014. We collected a total of 192 bottom grab samples to document macro-invertebrates and sediment characteristics. We conducted seismic-reflection profiling surveys to document stratigraphy and determine optimal locations for multiple sediment cores during the 2014 field season; we collected both Kullenberg and Livingstone cores. The seismic-reflection data, though conducted at the reconnaissance scale, proved useful to place the seafloor acoustic data in context. The acoustic and benthic habitat data and mapping products become more valuable when an understanding of the underlying stratigraphy is used as context for the benthic habitat maps. Sediment coring and analysis can provide insights into past and current basin evolution, which can further aid marine natural resource managers. However, we believe that stratigraphic data should be incorporated into standard benthic habitat mapping protocols. These multi-modal datasets provide a better understanding of these habitats for the multidisciplinary teams that typically produce and use these maps as well as coastal managers.
Myeloid-Derived Suppressor Cells as Target of Phosphodiesterase-5 Inhibitors in Host-Directed Therapeutics for Tuberculosis

Resistance toward current and new classes of anti-tuberculosis (anti-TB) antibiotics are rapidly emerging; thus, innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising novel approaches for shortening therapy regimens without inducing drug resistance. Development of new TB drugs is lengthy and expensive, and success is not guaranteed; thus, alternatives are needed. Repurposed drugs have already passed Food and Drug Administration (FDA) as well as European Medicines Agency (EMA) safety requirements and may only need to prove efficacy against Mycobacterium tuberculosis (M.tb). Phosphodiesterases (PDEs) hydrolyze the catalytic breakdown of both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) to their inactive mononucleotides. Advances in molecular pharmacology have identified 11 PDE families; and the success of sildenafil, a PDE-5 selective inhibitor (PDE-5i), in treating pulmonary hypertension and erectile dysfunction has invigorated research into the therapeutic potential of selective PDE inhibitors in other conditions. Myeloid-derived suppressor cells (MDSCs) suppress anti-TB T-cell responses, likely contributing to TB disease progression. PDE-5i increases cGMP within MDSC resulting in the downregulation of arginase-1 (ARG1) and nitric oxide synthase 2 (NOS2), reducing MDSC's suppressive potential. The effect of this reduction decreases MDSC-induced T-cell-suppressive mechanisms. This review highlights the possibility of HDT targeting of MDSC, using a PDE-5i in combination with the current TB regimen, resulting in improved TB treatment efficacy.
Infant Alveolar Macrophages Are Unable to Effectively Contain Mycobacterium tuberculosis

Infants are more likely to develop lethal disseminated forms of tuberculosis compared with older children and adults. The reasons for this are currently unknown. In this study we test the hypothesis that antimycobacterial function is impaired in infant alveolar macrophages (AMϕs) compared with those of adults. We develop a method of obtaining AMϕs from healthy infants using rigid bronchoscopy and incubate the AMϕs with live virulent Mycobacterium tuberculosis (Mtb). Infant AMϕs are less able to restrict Mtb replication compared with adult AMϕs, despite having similar phagocytic capacity and immunophenotype. RNA-Seq showed that infant AMϕs exhibit lower expression of genes involved in mycobactericidal activity and IFNγ-induction pathways. Infant AMϕs also exhibit lower expression of genes encoding mononuclear cell chemokines such as CXCL9. Our data indicates that failure of AMϕs to contain Mtb and recruit additional mononuclear cells to the site of infection helps to explain the more fulminant course of tuberculosis in early life.
Tissue Tolerance Coupled With Ionic Discrimination Can Potentially Minimize the Energy Cost of Salinity Tolerance in Rice

Salinity is one of the major constraints in rice production. To date, development of salt-tolerant rice cultivar is primarily focused on salt-exclusion strategies, which incur greater energy cost. The present study aimed to evaluate a balancing strategy of ionic discrimination vis-à-vis tissue tolerance, which could potentially minimize the energy cost of salt tolerance in rice. Four rice genotypes, viz., FL478, IR29, Kamini, and AC847, were grown hydroponically and subjected to salt stress equivalent to 12 dS m–1 at early vegetative stage. Different physiological observations (leaf chlorophyll content, chlorophyll fluorescence traits, and tissue Na+ and K+ content) and visual scoring suggested a superior Na+-partitioning strategy operating in FL478. A very low tissue Na+/K+ ratio in the leaves of FL478 after 7 days of stress hinted the existence of selective ion transport mechanism in this genotype. On the contrary, Kamini, an equally salt-tolerant genotype, was found to possess a higher leaf Na+/K+ ratio than does FL478 under similar stress condition. Salt-induced expression of different Na+ and K+ transporters indicated significant upregulation of SOS, HKT, NHX, and HAK groups of transporters in both leaves and roots of FL478, followed by Kamini. The expression of plasma membrane and vacuolar H+ pumps (OsAHA1, OsAHA7, and OsV-ATPase) were also upregulated in these two genotypes. On the other hand, IR29 and AC847 showed greater salt susceptibility owing to excess upward transport of Na+ and eventually died within a few days of stress imposition. But in the “leaf clip” assay, it was found that both IR29 and Kamini had high tissue-tolerance and chlorophyll-retention abilities. On the contrary, FL478, although having higher ionic-discrimination ability, showed the least degree of tissue tolerance as evident from the LC50 score (amount of Na+ required to reduce the initial chlorophyll content to half) of 336 mmol g–1 as against 459 and 424 mmol g–1 for IR29 and Kamini, respectively. Overall, the present study indicated that two components (ionic selectivity and tissue tolerance) of salt tolerance mechanism are distinct in rice. Unique genotypes like Kamini could effectively balance both of these strategies to achieve considerable salt tolerance, perhaps with lesser energy cost.
Object Categorization Processing Differs According to Category Level: Comparing Visual Information Between the Basic and Superordinate Levels

Object category levels comprise a crucial concept in the field of object recognition. Specifically, categorization performance differs according to the category level of the target object. This study involved experiments with two types of stimulus sequences (i.e., forward condition: presenting the target name before the line-drawing stimulus; and reverse condition: presenting the target name after the line-drawing stimulus) for both basic- and superordinate-level categorizations. Adult participants were assigned to each level and asked to judge whether briefly presented stimuli included the same object and target name. Here, we investigated how the category level altered the categorization process. We conducted path analyses using a multivariate multiple regression model, and set our variables to investigate whether the predictors affected the categorization process between two types of stimulus sequence. Dependent variables included the measures of performance (i.e., reaction time, accuracy) for each categorization task. The predictors included dimensions and shapes of the line-drawings, such as primary and local shape information, shape complexity, subject estimation, and other shape variables related to object recognition. Results showed that the categorization process differed according to shape properties between conditions only for basic-level categorizations. For the forward condition, the bottom-up processing of primary visual information depended on matches with stored representations for the basic-level category. For the reverse condition at the basic-level category, decisions depended on subjective ratings in terms of object-representation accessibility. Finally, superordinate-level decisions depended on higher levels of visual information in terms of complexity, regardless of the condition. Thus, the given category level altered the processing of visual information for object recognition in relation to shape properties. This indicates that decision processing for object recognition is flexible depending on the criteria of the processed objects (e.g., category levels).
White Matter Abnormalities of Auditory Neural Pathway in Sudden Sensorineural Hearing Loss Using Diffusion Spectrum Imaging: Different Findings From Tinnitus

Sudden sensorineural hearing loss (SSNHL) is a complex and challenging emergency which requires evidence regarding its pathophysiological changes to guide the treatment. The aim of this study was to evaluate the white matter integrity of the auditory neural pathway in patients with unilateral SSNHL in acute stage by using diffusion spectrum imaging tractography. In the present study, 60 individuals with acute SSNHL (29 males, 50.7 ± 11.8 years) and 25 healthy controls (13 males, 45.2 ± 13.2 years) underwent diffusion spectrum imaging tractography and high resolution T1 structural examinations using a 3T magnetic resonance imaging system. The areas of the auditory neural pathway were defined as regions of interest (ROIs). The quantitative anisotropy (QA) and the generalized fractional anisotropy (GFA) were compared between the patients with unilateral SSNHL and controls in these ROIs. We further evaluated the correlation between the parameter values and hearing loss level. The mean pure tone audiometry of patients at the onset presentation was 63.2 ± 26.2 dB. The right-sided SSNHL was involved in 25 (41.7%) cases and the left-sided in 35 (58.3%) cases. The QA values in the contralateral medial geniculate body, the bilateral anterior corona radiata and the anterior limb of internal capsule were significantly reduced in SSNHL patients compared to controls. In addition, the decrease QA value of the contralateral medial geniculate body was related to the increase severity of disease, even after controlling potential confounding factors. The present study demonstrated that patients with SSNHL exhibited altered integrity of white matter in the auditory neural pathway. Furthermore, the decreased QA values in the contralateral medial geniculate body might predict the severity of this disease. In the present study, tinnitus has not been found to effect in brain area obviously.
Complement-Independent Modulation of Influenza A Virus Infection by Factor H

The complement system is an ancient innate immune defense mechanism that can recognize molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface. Locally synthesized factor H at the site of infection/injury, including lungs, can act as a pattern recognition molecule without involving complement activation. Here, we report that factor H, a sialic acid binder, interacts with influenza A virus (IAV) and modulates IAV entry, as evident from down-regulation of matrix protein 1 (M1) in H1N1 subtype-infected cells and up-regulation of M1 expression in H3N2-infected A549 cells. Far-western blot revealed that factor H binds hemagglutinin (HA, ~70 kDa), neuraminidase (NA, ~60 kDa), and M1 (~25 kDa). IAV-induced transcriptional levels of IFN-α, TNF-α, IL-12, IL-6, IFN-α, and RANTES were reduced following factor H treatment for the H1N1 subtype at 6 h post-infection. However, for the H3N2 subtype, mRNA levels of these pro-inflammatory cytokines were enhanced. A recombinant form of vaccinia virus complement control protein (VCP), which like factor H, contains CCP modules and has complement-regulatory activity, mirrored the results obtained with factor H. Both factor H (25%), and VCP (45%) were found to reduce luciferase reporter activity in MDCK cells transduced with H1N1 pseudotyped lentiviral particles. Factor H (50%) and VCP (30%) enhanced the luciferase reporter activity for H3N2, suggesting an entry inhibitory role of factor H and VCP against H1N1, but not H3N2. Thus, factor H can modulate IAV infection and inflammatory responses, independent of its complement-related functions.
Approach to Resource Management and Physical Strength Predict Differences in Helping: Evidence From Two Small-Scale Societies

Helping behavior is likely to have evolved to increase chances of survival of an individual and their group. Nevertheless, populations differ significantly in their eagerness to help, and little is known about populational and inter-individual determinants of these differences. Previous studies indicated that economic and physiological factors might influence helping behavior. The aim of the present study was to investigate the effects of approach to resource management of a society (immediate-return economy vs. delayed-return economy), prenatal androgenization (based on second-to-fourth digit ratio), and physical strength (based on hand grip strength) on helping behavior toward others. Helping was assessed in terms of both general eagerness to help and differential helping toward: (1) kin, (2) other group members indiscriminately, (3) friends, and (4) those from whom help was obtained in the past. Based on data collected in two small-scale societies (n = 306), we found that people in the egalitarian immediate-return society (the Hadza hunter-gatherers of Tanzania) displayed helping behavior significantly more often than people in a more stratified delayed-return economy (Yali horticulturalists of Papua). Additionally, our results revealed that physical strength was a significant predictor of helping behavior in women but not in men. We discuss our findings in the light of the adaptive value of helping behavior.
Inactivation of FOXA2 by Respiratory Bacterial Pathogens and Dysregulation of Pulmonary Mucus Homeostasis

Forkhead box (FOX) proteins are transcriptional factors that regulate various cellular processes. This minireview provides an overview of FOXA2 functions, with a special emphasis on the regulation airway mucus homeostasis in both healthy and diseased lungs. FOXA2 plays crucial roles during lung morphogenesis, surfactant protein production, goblet cell differentiation and mucin expression. In healthy airways, FOXA2 exerts a tight control over goblet cell development and mucin biosynthesis. However, in diseased airways, microbial infections and proinflammatory responses deplete FOXA2 expression, resulting in uncontrolled goblet cell hyperplasia and metaplasia, mucus hypersecretion, and impaired mucociliary clearance of pathogens. Furthermore, accumulated mucus clogs the airways and creates a niche environment for persistent microbial colonization and infection, leading to acute exacerbation and deterioration of pulmonary function in patients with chronic lung diseases. Various studies have shown that FOXA2 inhibition is mediated through induction of antagonistic EGFR and IL-13R-STAT6 signaling pathways as well as through posttranslational modifications induced by microbial infections. An improved understanding of how bacterial pathogens inactivate FOXA2 may pave the way for developing therapeutics that preserve the protein's function, which in turn, will improve the mucus status and mucociliary clearance of pathogens, reduce microbial-mediated acute exacerbation and restore lung function in patients with chronic lung diseases.
Danhong Injection Protects Hemorrhagic Brain by Increasing Peroxiredoxin 1 in Aged Rats

Intracerebral hemorrhage (ICH) is a severe cerebrovascular disease with a high incidence, mortality and disability rate. Danhong injection (DHI) is beneficial for ischemic stroke, but is prohibited for ICH due to risk of bleeding. The present study aims to explore the potential therapeutic time window and molecular mechanism of DHI in a collagenase-induced ICH model in aged rats. DHI administration after ICH could significantly improve body weight and neurological deficits, and reduce the hematoma volume and brain water content when compared to the vehicle control. Furthermore, the protective effect of DHI administration on days 1–3 after ICH was superior to those on days 3–5 or 7–9 after ICH. DHI remarkably increased the Peroxiredoxin 1 (Prx1) expression in astrocytes and reduced the expression of inflammatory factors tumor necrosis factor-α (TNF-α) and interleukin-β (IL-1β) after ICH. The immediate treatment of Prx1 inhibiter chelerythrine (Che) after ICH abolished the protective effect of DHI. Furthermore, the Che treatment reduced the expression of Prx1 in astrocytes, but increased the expression of TNF-α and IL-1β after ICH. DHI treatment could not reverse these changes. Therefore, the earlier DHI is administered, the better the neuroprotective effect. DHI exerts antioxidative and anti-inflammatory function by increasing Prx1 in astrocytes. These present results may change the established understanding of DHI, and reveal a novel treatment approach for ICH.
On the Competitive Mechanism Concerning the Third-Party Transaction in Chinese Market

Abstract This paper seeks to position the third-party transaction (TPT) in the macrostructure of Chinese market in terms of Concentration Ratio and Herfindahl-Hirschman Index. By extending both Cournot oligopolistic and Stackelberg oligopolistic competition models, a new oligopolistic competition model is established for China’s TPT market. Based on multidimensional game, a pricing game model is theorized accordingly to elucidate the TPT platform. The influence of various factors on the price of the TPT platform is verified with numerical simulation. The formation of monopoly is an inevitable consequence of the “one superpower and multi powers” market structure given the unregulated development of TPT enterprises as the prerequisite. In addition, through the studies on telecom payment market, such unregulated development can also cause the “big-three” domination for the TPT enterprises in the “multi powers” market structure. Based on our modelizations, this paper serves to provide prospect recommendations for policy-making of state supervision authorities.
Thinking Like (Law-And-) Economists – Legal Rules, Economic Prescriptions and Public Perceptions of Fairness

Abstract Using vignettes that are based on seminal cases in law and economics, I find that judicial decisions across different areas of the common law are considered to be fairer when they follow prescriptions for efficiency based on law-and-economic reasoning. Vignettes describe legal disputes and require respondents to rate the fairness of a judge’s resolution. For each vignette, fairness ratings are compared across a version that follows a particular economic prescription and a version that does not, with differences across versions generated by subtle changes in context that are motivated by the economic logic that either was used in the relevant case’s actual judicial opinion or has been applied to the case by scholars of law and economics. The results suggest that the economic logic that underlies the Coase theorem, the Hand rule and the foreseeability doctrine, and generates prescriptions for efficient use of strict product liability and efficient breach of contract, aligns with lay intuitions of fairness. The results also identify two areas, fugitive property and punitive damages, where law-and-economic prescriptions do not align with perceptions of fairness.
Shaping the Parameters of Cylindrical Belt Surface in the Joint Area

Abstract Most of the industrial machines use round-shaped drive belts for power transfer. They are often a few millimetres in diameter, and made of thermoplastic elastomer, especially polyurethane. Their production process requires the bonding step, which is often performed by butt welding, using the hot plate method. The authors have undertaken to design an automatic welding machine for this purpose. Consequently, it is required to carry out a process analysis of hot plate welding, which entails describing the dependency between technological parameters (temperature, pressure force, time) and the quality of the joint, especially the outer surface of the belt around the weld. To analyse this process in a proper way, it is necessary to describe the physical phenomena that occur in the material, during particular operations of the hot plate welding process. One of the most troublesome phenomena occurring during the welding process is removing of the flash. These round rings, placed around the weld, which remains after the joining process, are unacceptable in the finished component. The authors took an effort to design the necessary equipment for removing of the flash after welding, using some simple parts that cut off excessive material. The paper shows the three possible solutions for flash removal. They were verified experimentally, and afterwards, the best solution was chosen. Additionally, a number of analytical calculations were carried out in order to determine the maximum force value required for this operation. Results of the analytical calculations were compared with experimental results.