Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyse physique des phenomenes associes au ballottement de liquide dans des reservoirs (sloshing)

Une approche experimentale du ballottement de liquide (sloshing) dans un reservoir mobile partiellement rempli est entreprise par l'etude de la dynamique de la surface libre et des pressions d'impacts associees. Une etude bibliographique preliminaire, comprenant une analyse dimensionnelle du probleme montre l'existence de parametres physiques (remplissage, pression d'ouillage,) influencant la dynamique de la surface libre et/ou les niveaux de pression. De plus, la synthese des publications concernant les impacts hydrodynamiques de slamming indique l'influence, sur les caracteristiques des pressions impulsives, de phenomenes locaux introduisant des parametres supplementaires. Apres une etude des techniques de modelisation du sloshing, usuelles ou developpees pour le present travail, on presente une analyse experimentale globale du phenomene, fondee sur des mesures de pression et des descriptions d'ecoulement, qui contribue a une meilleure comprehension de l'influence des parametres physiques. Ensuite, une etude plus fine du phenomene local d'impact est menee pour quelques configurations particulieres de sloshing a l'aide de mesures simultanees de pressions impulsives en plusieurs points d'une grille, et d'enregistrements rapides synchronises de visualisations d'ecoulements. Une attention particuliere est portee sur le controle des conditions d'experience et l'evaluation des parametres issus de l'analyse bibliographique du slamming (vitesse d'impact, incidence surface libre/paroi,). On observe l'apparition de phenomenes diphasiques pendant l'impact (emprisonnement de poches ou bulles de gaz, cavitation). En outre, les repartitions spatio-temporelles des caracteristiques des pressions impulsives (pic, duree,) dans et a proximite des zones d'impact sont determinees. Les relations pression-vitesse sont evaluees pour les conditions les plus severes. Enfin, une approche numerique du probleme est realisee en confrontant des calculs du code tummac a l'experience et a ceux d'un autre code, commercialise (lr-fluids)
Laparoscopic live donor nephrectomy: the University of Maryland 3-year experience.

PURPOSE We determined whether laparoscopic living donor nephrectomy decreases the morbidity of renal donation for the donor, while providing a renal allograft of a quality comparable to that of open donor nephrectomy. MATERIALS AND METHODS In a 3-year period laparoscopic donor nephrectomy was performed via the transperitoneal approach. We evaluated donor and recipient medical records for preoperative donor characteristics, intraoperative parameters and complications, and postoperative recovery and complications. RESULTS Of the 320 laparoscopic donor nephrectomies performed the left kidney was removed in 97.5%. Intraoperative complications, which developed in 10.4% of cases, tended to occur early in the experience and required conversion to open nephrectomy in 5. Average operative time was 31/2 hours and warm ischemia time was 21/2 minutes. As the series progressed, blood loss as well as laparoscopic port size and number decreased but extraction site size remained constant at 7 cm. Urinary retention, prolonged ileus, thigh numbness and incisional hernia were the most common postoperative complications. Postoperative analgesic requirements were low and average hospitalization was 66 hours. CONCLUSIONS Laparoscopic donor nephrectomy appears to be safe and decreases morbidity in the renal donor. Allograft function is comparable to that in open nephrectomy series. The availability of laparoscopic harvesting may be increasing the living donor volunteer pool.
Behçet's disease: infectious aetiology, new autoantigens, and HLA-B51

Behcet's disease (BD) is a multisystemic disorder with mucocutaneous, ocular, arthritic, vascular, and central nervous system involvements.1 Recent developments in the immunopathogenesis of BD are discussed in this review. Box FB1 summarises the major aspects covered. Figure FB1 Immunopathogenic aspects of Behcet's disease Neutrophils are mature immune cells with a very short life in vitro and have a pivotal role in innate immune responses. As typical BD lesions such as pustular folliculitis, pathergy reactions, and hypopyon have significant neutrophil infiltrations, neutrophil functions and activation status have been extensively investigated.1 2 Conflicting reports of increased, normal, or decreased basal and fMLP stimulated superoxide productions, phagocytosis, chemotaxis, and neutrophil-endothelial adhesion in BD may reflect the status of clinical activity, in vivo neutrophil activation, drug effects, or just methodological problems of investigating neutrophils.3-9 In a recent study, which showed decreased fMLP stimulated superoxide production in BD and patients with sepsis, consecutive restimulations of prestimulated BD neutrophils produced a smaller increase in superoxide production than in healthy controls, implying a state of in vivo neutrophil preactivation.9 An in vivo “primed” state of neutrophils with a dual signalling system for activating neutrophil oxidase has been suggested previously.10 Agents such as fMLP or the cytokines, tumour necrosis factor α (TNFα) and granulocyte monocyte colony stimulating factor, have been shown to increase tyrosine phosphorylation of various intracellular proteins and to prime neutrophils in vivo without full activation, which might also be the case in BD with its proinflammatory cytokines. In HLA-B51 transgenic mice, a presumed model for BD, the only abnormality seen is increased superoxide release …
AMIR-ST: Propuesta de una Aproximación Metodológica para la Ingeniería de Requisitos de Sistemas Telemáticos

En el presente articulo se propone a AMIR-ST (Aproximacion Metodologica para la Ingenieria de Requisitos de Sistemas Telematicos), como un conjunto articulado y bien balanceado de metodos para el flujo de trabajo de Ingenieria de Requisitos, que constituye un proceso de desarrollo fundamentado en la interaccion continua con los usuarios, la obtencion del Modelo de Negocio, el desarrollo de escenarios y el uso de una notacion consistente con UML; aspectos que en conjunto facilitan los procesos de comunicacion entre clientes, analistas y desarrolladores optimizando los procesos de identificacion, especificacion, gestion, reutilizacion, escalabilidad y rastreabilidad de requisitos durante todo el ciclo de vida de construccion de una solucion. Palabras claves: Ingenieria de Requisitos, Sistemas Telematicos.
Binary-Code-Allocation Scheme in DS-CDMA Systems

In this paper, we consider a simple binary-transmitter adaptation in direct-sequence code-division multiple-access systems. We propose a binary-code-allocation scheme for reducing the multiple-access interference (MAI). In this scheme, a user is given an orthogonal binary sequence set. By choosing a better sequence from the sequence set, the user can maximize his/her signal to interference ratio. We examine the scheme analytically by both exact analysis and approximation in equal-power synchronous cases. Theoretically, it is found that the scheme can significantly reduce the MAI. It only involves a few bits of feedback information for the transmitter to adjust the sequences. The scheme can also be modified for multiuser adaptation in asynchronous channels. In a multiuser adaptation, simulations show that the users would have a significantly improved performance against the MAI, and the system throughput can also be increased. It is shown that this binary-code-allocation scheme is a simple, widely applicable, and robust binary-sequence-adaptation scheme
Geographic Diversity of Low-Volume Hospitals in Total Knee Replacement: Implications For Regionalization Policies

Background/Objectives:Centers performing low volumes of total knee replacements (TKR) have worse outcomes of TKR than higher volume centers. Regionalization policies that shift patients to higher volume centers are being considered as a means of improving TKR outcomes. We sought to describe geographic diversity in the distribution of low-volume centers and examine state level characteristics associated with states that have a higher proportion of low-volume centers and/or a higher proportion of TKRs performed in low-volume centers. Methods:We used U.S. Census data and geocoded Medicare claims to ascertain state-level demographic factors, procedure volume, and TKR rates and to conduct our state level analysis. We defined 2 outcomes: 1) proportion of all hospitals with a low annual TKR volume (<26 per year in the Medicare population); and 2) proportion of all TKRs in the Medicare population performed in low-volume centers. We examined linear associations among the 2 outcomes and state factors, and used multivariate regression to identify factors associated independently with these outcomes. Results:Half of hospitals performing TKR in the Medicare population were low-volume centers, accounting for 13% of TKRs. Multivariate analysis revealed lower TKR rates, higher proportion of rural areas and larger state area were associated with a higher proportion of low-volume hospitals in a state. Lower proportion of elderly residents, higher population density and higher proportion of rural areas predicted a higher proportion of TKRs performed in low-volume centers. Conclusions:The distribution of low-volume hospitals among U.S. states varies substantially. Regionalization of TKR may require different strategies in states with small and large numbers of low-volume centers.
New multivariate linear regression real and reactive branch flow models for volatile scenarios

Nonlinearity of power flow equations is one of the major underlying factors in a power systems operation complexity. The need for a robust and less complex models rises in a volatile, dynamic and real time scenario. This paper introduces new empirical models using multivariate linear regression (MLR) methods with least squares for both real and reactive branch flows. The models do not make prior assumptions and do not depend on a particular base case. Instead they are trained on either simulated or historical data. Tests using the IEEE 14 bus system show that given similar input variables to DC models, the MLR models performs significantly better. They also show that the MLR models have good prediction accuracy in scenarios with high volatility.
Pre‐exposure of neuroblastoma cell line to pulsed electromagnetic field prevents H2O2‐induced ROS production by increasing MnSOD activity

Electromagnetic fields (EMFs) have been linked to increased risk of cancers and neurodegenerative diseases; however, EMFs can also elicit positive effects on biological systems, and redox status seems crucially involved in EMF biological effects. This study aimed to assess whether a short and repeated pulsed EMF (PEMF) could trigger adaptive responses against an oxidative insult in a neuronal cellular model. We found that a 40 min overall (four times a week, 10 min each) pre‐exposure to PEMF did not affect major physiological parameters and led to a significant increase of Mn‐dependent superoxide dismutase activity in the human neuroblastoma SH‐SY5Y cell line. In addition, we found PEMF‐pre‐exposed cells exhibited decreased reactive oxygen species production following a 30 min H2O2 challenge, with respect to non pre‐exposed cells. Our findings might provide new insights on the role played by short and repeated PEMF stimulations in the enhancement of cellular defenses against oxidative insults. Although studies in normal neuronal cells would be useful to further confirm our hypothesis, we suggest that specific PEMF treatments may have potential biological repercussions in diseases where oxidative stress is implicated. Bioelectromagnetics. Bioelectromagnetics. 36:219–232, 2015. © 2015 Wiley Periodicals, Inc.
Allowing vanishing stability margins in preservation of (i)ISS dissipation inequalities by scaling

Scaling of Lyapunov functions is one of effective tools in analyzing and designing dynamical systems from components. Integral input-to-state stability and input-to-state stability are notions which allow one to make use of dissipation inequalities in such modular-based analysis with the help of nonlinear gain which may not be globally defined. Effectively selecting nonlinear scalings is crucial for coping with nonlinearities in components without causing degradation of dissipative properties and their estimates. This paper focuses on scalings for systems which do not admit uniform stability margins and proposes new tools applicable to cases which have not been addressed in the literature. In addition to demonstrating preservation of (i)ISS dissipation inequalities by scaling, this paper illustrates the usefulness of the proposed scaling formulas in analyzing stability of cascaded systems through examples.
Dietary patterns in the Belfast MONICA Project

MONICA Project (multinational monitoring of trends and determinants in cardiovascular disease; World Health Organization 1983). This is a 10-year study which aims to relate trends in incidence (mortality and morbidity) to changes in the levels of the major risk factors measured in three independent community surveys. The Belfast MONICA Project began in 1983 and will run until the end of 1992. of The Dietary Survey was one of a number of nutrition surveys carried out by the Belfast MONICA Project. Other studies include INTERSALT (a multi-centre comparison relating salt excretion to mean blood pressure in the CARDIAC (a Japanese study of salt and hypertension) and a study of the role of antioxidants in using ruler flat vertical Electronic Seca used the nearest 0.1 All heavy outdoor before Skinfold thicknesses were measured in triplicate at three sites (biceps, triceps and subscapular) using John Bull skinfold calipers.
Learning a cost function for microscope image segmentation

Quantitative analysis of microscopy images is increasingly important in clinical researchers' efforts to unravel the cellular and molecular determinants of disease, and for pathological analysis of tissue samples. Yet, manual segmentation and measurement of cells or other features in images remains the norm in many fields. We report on a new system that aims for robust and accurate semi-automated analysis of microscope images. A user interactively outlines one or more examples of a target object in a training image. We then learn a cost function for detecting more objects of the same type, either in the same or different images. The cost function is incorporated into an active contour model, which can efficiently determine optimal boundaries by dynamic programming. We validate our approach and compare it to some standard alternatives on three different types of microscopic images: light microscopy of blood cells, light microscopy of muscle tissue sections, and electron microscopy cross-sections of axons and their myelin sheaths.
A Cis-acting A-U Sequence Element Induces Kinetoplastid U-insertions*

A 34-nucleotide A-U sequence located immediately upstream of the editing sites of the Leishmania tarentolaecytochrome b mRNA induces a mitochondrial extract to insert U nucleotides independent of guide RNA. Insertions are localized to positions immediately 5′ and 3′ of the A-U sequence. When placed within an unedited mammalian transcript, the A-U sequence is sufficient to induce U-insertions. The sequence has a high degree of similarity with the templating nucleotides of a cytochrome b guide RNA and with a sequence adjacent to the editing sites in ND7 mRNA, the other characterized kinetoplastid mRNA supporting guide RNA-independent U-insertions. At least one protein specifically interacts with the A-U sequence. The reaction is consistent with a mechanism proposed for guide RNA-directed editing.
PKP2 mutations in sudden death from arrhythmogenic right ventricular cardiomyopathy (ARVC) and sudden unexpected death with negative autopsy (SUDNA).

BACKGROUND Plakophilin2 (PKP2) is a desmosome-related protein with numerous armadillo repeats and has been linked to arrhythmogenic right ventricular cardiomyopathy (ARVC). Fatal arrhythmias resulting in sudden death also occur in the absence of morphologic cardiac abnormalities at autopsy, and have been linked to ion channel mutations in a subset of cases, but so far not to PKP2. METHODS AND RESULTS We sequenced all 14 exons of PKP2 in DNA extracted from postmortem heart tissues of 25 patients dying from ARVC and 25 from sudden unexpected death with negative autopsy (SUDNA). The primers were designed using the Primer Express 3.0 software. Direct sequencing for both sense and antisense strands was performed with a BigDye Terminator DNA sequencing kit on a 3130XL Genetic Analyzer. Mutation damage prediction was made using Mutation Taster, Polyphen and SIFT software. In 6 of the 25 ARVC samples, 6 PKP2 mutations were identified, 4 of which were likely significant, and 3 of which were novel (p.N641del, p.L64PfsX22, p.G269R). In 6 of the 25 cases of SUDNA samples, 6 PKP2 mutations were identified, 3 of which were likely significant, and 4 of which were not previously described (p.P665S, p.Y217TfsX45, p.E540, p.S615T). CONCLUSIONS PKP2 mutations are not specific for ARVC and may result in SUDNA. The link between ARVC and desmosomal mutations may not be causal but related to an association between defective desmosomal proteins and arrhythmias.
Lífefnaskimun fyrir fósturgöllum

Lifefnaskimun fyrir fosturgollum er um það bil 30 ara gomul. I fyrstu var markmiðið leit að miðtaugakerfisgollum með maelingum a α-fetoproteini i maeðrasermi (MS-AFP) og legvatni (Lv-AFP). Fyrir tilviljun uppgotvaðist að lagt AFP i maeðrasermi sast oftar við litningafrabrigði hja fostri og jukust þa rannsoknir a notkun lifefnamaelinga i forburðarskimun. I kjolfarið voru þrouð fjolþatta prof sem meta likindi a litningafrabrigði fosturs. Svonefnd tviprof, þriprof og fjorprof a oðrum þriðjungi meðgongu hafa mest verið notuð i þessu skyni en lokagreiningu verður að gera með litningarannsokn a frumum ur fostri. A Islandi hafa almennt ekki verið notaðar lifefnamaelingar i forburðarskimun heldur er þunguðum konum eldri en 35 ara boðin litningarannsokn beint. Þetta fyrirkomulag þarf að endurskoða. A siðustu arum hefur verið þrouð lifefnaskimun fyrir litningafrabrigðum byggð a maelingum a PAPP-A (pregnancy associated plasma protein A) og friu β-hCG (free β-human chorionic gonadotropin) i maeðrasermi i meðgonguviku 11-13. Þetta prof er haegt að nota eitt ser en betri skimhaefni naest ef jafnframt er gerð hnakkaþykktarmaeling a fostri i snemmomskoðun og reiknað samþaett likindamat fyrir fosturgalla.
The Dirichlet Problem for Degenerate Hessian Equations

Abstract In this paper, we study the Dirichlet problem for a class of fully nonlinear degenerate elliptic equations which depend only on the eigenvalues of the Hessian matrix. We provide a new and simpler approach to the estimation of second derivatives, through differentiation with respect to vector fields with skew-symmetric Jacobians.
Antenatal Depression in a Tertiary Care Hospital

Context: Antenatal depression is not easily visible, though the prevalence is high. The idea of conducting this study was conceived from this fact. Aims and Objectives: The aim of this study was to estimate the prevalence of antenatal depression and identify the risk factors, for early diagnosis and intervention. Settings and Design: The study conducted in a Tertiary Care Hospital was prospective and cross-sectional. Materials and Methods: Pregnant women between 18 and 40 years of age were studied. The sample size comprised 318 women. They were assessed using Edinburgh Postnatal Depression Scale (EPDS) score, Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders, Life Event Stress Scale (LESS), and Life Distress Inventory (LDI). Statistical Analysis Used: The Statistical Package for Social Sciences (SPSS) Version 15 software was used to measure percentages, mean, correlation, and P < 0.05 were considered significant. Results: Prevalence of antenatal depression in the study was 12.3%. Correlation of the sociodemographic factors, obstetric factors, LDI, and LESS with EPDS scores showed statistical significance for unplanned pregnancy, distress associated with relationships, physical health, financial situation, social life, presence of personality disorder, being a homemaker, and higher educational status. Conclusion: The study showed a high prevalence rate of depression and identified risk factors.
Exposure to Schistosoma mansoni infection in a rural area in Brazil. II: Household risk factors

A number of studies have pointed out the potential importance of the household in the transmission of schistosomiasis. The clustering of domestic activities associated with water collection, storage, and usage can result in the sharing of transmission sites and infective water contact behaviours. In this study, we employed a variance component method to estimate effects due to individual risk factors and shared residence on the variance in faecal egg counts during Schistosoma mansoni infection. A suite of covariates, which included demographic, socioeconomic, water supply, and water contact behaviour terms, contributed 15% to the variance in faecal egg counts. Shared residence alone accounted for 28% of the variance in faecal egg excretion. When both the suite of covariates and shared residence were considered in the same model, shared residence still contributed 22% to the variance in infection intensity. These results point to the importance of shared residence as a means of capturing the complex interrelationship between shared demographic, socioeconomic, physical environmental, and behavioural factors that influence transmission of schistosomiasis at the household level.
jneumeth new cross-correlation algorithm for the analysis of “ in vitro ” neuronal network ctivity aimed at pharmacological studies

Modern drug discovery for Central Nervous System pathologies has recently focused its attention to in vitro neuronal networks as models for the study of neuronal activities. Micro Electrode Arrays (MEAs), a widely recognized tool for pharmacological investigations, enable the simultaneous study of the spiking activity of discrete regions of a neuronal culture, providing an insight into the dynamics of networks. Taking advantage of MEAs features and making the most of the cross-correlation analysis to assess internal icro Electrode Arrays
Quantification of bleeding volume using computed tomography and clinical complications after percutaneous renal biopsy

Background: The aim of this study was to investigate specific bleeding volume after percutaneous renal biopsy (PRB) and the correlation between bleeding volume and clinical parameters. Methods: A retrospective study of 252 consecutive patients (153 male patients and 99 female patients) who underwent PRB at the Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, between July 2013 and January 2016 was conducted. PRB was performed under ultrasound guidance using an automated spring-loaded biopsy device and a 16-cm, 16-gauge needle. Patients underwent computed tomography (CT) the day after PRB. Bleeding volume after PRB was evaluated using reconstructed CT data. Results: The median bleeding volume after PRB was 38 mL (25th–75th percentile, 18–85 mL), with ≥4 punctures identified as a risk factor for massive bleeding. The incidence rates of macrohematuria, transient hypotension and bladder obstruction were 14.3, 8.7 and 4.7%, respectively. Post-PRB blood transfusion and intervention were required in 4.7 and 0.8% of patients, respectively. Conclusion: Although it is difficult to assess the risk for massive bleeding prior to PRB, we do provide evidence of a specific increased risk with ≥4 puncture attempts, and recommend careful follow-up of these patients.