Miracle-dz/UniFAR-FTUs huggingface dataset:
A strength-oriented exercise session required more recovery time than a power-oriented exercise session with equal work

The present randomized cross-over controlled study aimed to compare the rate of recovery from a strength-oriented exercise session vs. a power-oriented session with equal work. Sixteen strength-trained individuals conducted one strength-oriented session (five repetitions maximum (RM)) and one power-oriented session (50% of 5RM) in randomized order. Squat jump (SJ), countermovement jump (CMJ), 20-m sprint, and squat and bench press peak power and estimated 1RMs were combined with measures of rate of perceived exertion (RPE) and perceived recovery status (PRS), before, immediately after and 24 and 48 h after exercise. Both sessions induced trivial to moderate performance decrements in all variables. Small reductions in CMJ height were observed immediately after both the strength-oriented session (7 ± 6%) and power-oriented session (5 ± 5%). Between 24 and 48 h after both sessions CMJ and SJ heights and 20 m sprint were back to baseline. However, in contrast to the power-oriented session, recovery was not complete 48 h after the strength-oriented session, as indicated by greater impairments in CMJ eccentric and concentric peak forces, SJ rate of force development (RFD) and squat peak power. In agreement with the objective performance measurements, RPE and PRS ratings demonstrated that the strength-oriented session was experienced more strenuous than the power-oriented session. However, these subjective measurements agreed poorly with performance measurements at the individual level. In conclusion, we observed a larger degree of neuromuscular impairment and longer recovery times after a strength-oriented session than after a power-oriented session with equal total work, measured by both objective and subjective assessments. Nonetheless, most differences were small or trivial after either session. It appears necessary to combine several tests and within-test analyses (e.g., CMJ height, power and force) to reveal such differences. Objective and subjective assessments of fatigue and recovery cannot be used interchangeably; rather they should be combined to give a meaningful status for an individual in the days after a resistance exercise session.
Mechanistic insights into cardiovascular protection for omega-3 fatty acids and their bioactive lipid metabolites

Abstract Patients with well-controlled low-density lipoprotein cholesterol levels, but persistent high triglycerides, remain at increased risk for cardiovascular events as evidenced by multiple genetic and epidemiologic studies, as well as recent clinical outcome trials. While many trials of low-dose ω3-polyunsaturated fatty acids (ω3-PUFAs), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) have shown mixed results to reduce cardiovascular events, recent trials with high-dose ω3-PUFAs have reignited interest in ω3-PUFAs, particularly EPA, in cardiovascular disease (CVD). REDUCE-IT demonstrated that high-dose EPA (4 g/day icosapent-ethyl) reduced a composite of clinical events by 25% in statin-treated patients with established CVD or diabetes and other cardiovascular risk factors. Outcome trials in similar statin-treated patients using DHA-containing high-dose ω3 formulations have not yet shown the benefits of EPA alone. However, there are data to show that high-dose ω3-PUFAs in patients with acute myocardial infarction had reduced left ventricular remodelling, non-infarct myocardial fibrosis, and systemic inflammation. ω3-polyunsaturated fatty acids, along with their metabolites, such as oxylipins and other lipid mediators, have complex effects on the cardiovascular system. Together they target free fatty acid receptors and peroxisome proliferator-activated receptors in various tissues to modulate inflammation and lipid metabolism. Here, we review these multifactorial mechanisms of ω3-PUFAs in view of recent clinical findings. These findings indicate physico-chemical and biological diversity among ω3-PUFAs that influence tissue distributions as well as disparate effects on membrane organization, rates of lipid oxidation, as well as various receptor-mediated signal transduction pathways and effects on gene expression.
The 3D Architecture of Interphase Microtubule Cytoskeleton and Functions of Microtubule Plus End Tracking Proteins in Fission Yeast

The microtubule (MT) cytoskeleton is important for establishing polar growth in the rod-shaped fission yeast (Schizosaccharomyces pombe). In these cells, MTs form an architectural scaffold of the cell by positioning organelles such as the nucleus and mitochondria. Interphase MTs are arranged in bundles along the cell’s long axis. The filaments start growing in the cell’s middle in a zone of anti-parallel overlap, from which the more dynamic plus ends of MTs extend towards both cell ends. After cell division the cell grows exclusively from the old end (away from the septum), where the growth machinery is still present from the mother cell. New end take off (NETO) occurs after about a third of the way through the cell cycle, when F-actin has moved into the new end. From this point onwards maintenance of polar growth is MT independent and occurs at both cell ends. Guidance of the microtubules to the cell ends is performed by plus end tracking proteins (+TIPs), such as Tea1 and Tip1 (Clip-170). Tea1 is a landmark protein localizing to the cell ends. Tip1 is an anti-catastrophe factor that prevents MT depolymerization before the filament has reached the cell end. The delivery of Tip1 to MT ends is motors dependent and another +TIP, Mal3, anchors it at the MT end. Mal3 (EB1) stabilizes MTs, possibly by fortify its seem. Here we describe a large-scale, electron tomography investigation of wild-type (WT) S. pombe cells, including the first 3D reconstruction of a complete eukaryotic cell volume. Sufficient resolution to show both how many MTs there are in a bundle and their detailed architecture was achieved. Most cytoplasmic MTs are open at one end and capped at the other, providing evidence about their polarity. Electron-dense bridges between the MTs themselves and between MTs and the nuclear envelope were frequently observed. Finally, we have investigated structure/function relationships between MTs and both mitochondria and vesicles. Using the same approach, we then analyzed the bundle architechture in tip1Δ and mal3Δ mutants. MTs were half the length of WT in mal3Δ and a quarter the length of WT in tip1Δ. Further, there were less than half as many MTs in a bundle in tip1Δ then in WT. In contrast, mal3Δ bundles no difference in the amount of filaments in a bundle. However, structural differences of the MT lattice were observed in both mutants. The interaction between MTs and the spindle pole body was altered in both strains. Our analysis shows that electron tomography of well-preserved cells is ideally suited for describing fine ultrastructural details that were not visible with previous techniques.
Hormonal Profile And Histopathological Study On The Influence Of Silymarin On Both Female And Male Albino Rats

Silymarin is a mixture of flavonoids extracted from seeds of milk thistle (Silybum marianum [L] Gaertn ). Extracts of S. marianum have been used in the treatment of liver diseases for more than 2000 years. Flavonoids are a large group of polycyclic phenols of plant origin. Flavonoids displaying estrogenic effects (phytoestrogen). Phytoestrogens show an estrogenic activity owing to the structural similarity with the estrogen skeleton ,mimicking natural estrogens, it binds to estrogen receptor and modulates its activity . These effects cause complex changes inducing a shift in an overall hormonal balance of the individual. Long term intake of feeds with a higher content of phytoestrogens can induce transient or permanent infertility. Silybum marianum leaves have been traditionally used in Egypt for their antifertility effects . Also, the antifertility property of silybum marianum leaves was investigated in female albino rats. This property highlights the impotance to clarify the role of silymarin (420mg /day ) a human therapeutic dose on both female and male albino rats. Silymarin (151.2 mg/kg BW) prevented pregnancy in adult female albino rats on days 1-5 post coitum. In female rats the follicle stimulating hormone (FSH) displayed marked increase, while the luteinizing hormone (LH) and estradiol remained within normal levels. These results showed a distinct increase in number and size of ovarian growing follicles while the effect of silymarin on the uterine wall was in the form of hypertrophy of endometrial epithelium, also increase in the number of uterine glands. Ovaries taken from females treated with silymarin for one and two months contained a large number of growing follicles. In male rats treated with silymarin (151.2 mg/kg BW) for one month, testosterone and LH were increased significantly, meanwhile estradiol not changed. Testes of rats treated with silymarin for one month showed well developed spermatogenesis with lot of sperms. The epididymis of the same group contained a heavy number of sperms. While rats treated with silymarin for two months displayed significant decrease in serum testosterone levels, while LH and estradiol not changed. These rats displayed some tubules contained well developed spermatogenic layer and normal leyding cells, others appeared moderated by affected. The epididymis contained less number of sperms. These results indicated that silymarin (151.2mg /kgBW) a dose equivalent to human therapeutic dose (420mg/ day) prevented pregnancy in female rats and caused some histological changes in the ovary and uterus, while it has biological benefits for male rats during short treatment.
THE RESPIRATORY CENTRE IN THE TENCH (TINCA TINCA L.) II. RESPIRATORY NEURONAL ACTIVITY IN THE MEDULLA OBLONGATA

1. The medulla of the tench brain was searched systematically by means of needle electrodes for rhythmic bursts of action potential activity coinciding with the breathing movements. 2. The neurones which produced these rhythmic bursts of activity were located in the grey matter, mainly beneath the IXth and Xth motor nuclei and in the region round the VIIth motor nucleus. This type of activity was also found in some of the neurones forming the Vth and VIIth motor nuclei. 3. The respiratory neurones were not arranged in a discrete and homogenous nucleus anywhere in the medulla, but were scattered through the grey matter. The distribution was not uniform, the neurones tending to occur in very small groups. There was also a relatively higher density of respiratory neurones in the central, as compared with the more anterior and posterior, parts of the respiratory region. The possibility that variations may occur in the constitution of the respiratory centre, in different individuals and in the same individual at different times, is considered. 4. The manner in which neurones of the respiratory centre function to produce the rhythmic activity is discussed. Localized destruction of active respiratory regions, over a wide area of the medulla in different fish, was never followed by a breakdown in the rhythmic movements. This is interpreted as evidence against the existence of a pacemaker and favouring the hypothesis that the rhythm is produced by a general reciprocal interaction of large numbers of respiratory neurones.
Professional and organizational commitment of university research professors

Professional commitment of university research professors is initially fostered by an internalized code of ethics, inculcated during an extensive training process, and further maintained by colleague authority. Professional commitment may however be eroded by current internal problems in the professions. Furthermore, the research professor functions within the constraints of the larger university system. The unique university research system, as well as the role of research administrators, may influence the development of the professor's organizational commitment. The relationship between the professor's professional organizational commitment is discussed. Blau and Scott's model of this particular relationship is criticized and alternate viewpoints are given. Die professlonele verbintenis van professore wat navorsing doen aan universiteite word in die eerste plek bevorder deur 'n geinternaliseerde etiese kode wat ingeprent is gedurende 'n intensiewe opleldingsproses en onderhou word deur kollegiale gesag. Professionele verbintenls mag egter ondermyn word deur huidige interne probleme wat deur die professies ondervind word. Verder funksioneer die navorsende professor ook binne die beperkinge van die groter universiteitstelsel. Hierdie unieke universiteitsnavorsingstelsel, sowel as die rol van die navorsingsadministreerders, mag die ontwikkeling van die professor se verbintenis ten opsigte van die instansie beinvloed. Die verwantskap tussen die professor se professionele verbintenis en die van die instansie word bespreek. Blau en Scott se model van hierdie besondere verwantskap word gekritiseer en ander sienings gegee.
Channel consistency and inconsistency in the communications of married couples

48 married couples were videotaped while they discussed their relationship. The conversation was divided into thought units (basically speaker turns), and each unit was coded 4 times. Positive messages were used more by Ss with high and moderate levels of marital adjustment (MAD) (as measured by the short Marital Adjustment Test), whereas negative messages were used more by Ss low in MAD. Neutral messages were used more by males than females, particularly among the low-MAD Ss. Over all adjustment levels, neutral messages were used more in the verbal channel, positive messages were used less in the verbal channel, and negative messages were used less in the verbal and visual channels. The most frequently occurring discrepancies were those with positivity in the visual channel and negativity in the verbal or vocal channels, particularly the vocal channel. The percentage of discrepancies involving positivity in the visual channel and negativity in the vocal channel increased linearly from the high- to low-MAD Ss, with females generally using more of these communications than males. (39 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved).
Tipping point and noise-induced transients in ecological networks

A challenging and outstanding problem in interdisciplinary research is to understand the interplay between transients and stochasticity in high-dimensional dynamical systems. Focusing on the tipping-point dynamics in complex mutualistic networks in ecology constructed from empirical data, we investigate the phenomena of noise-induced collapse and noise-induced recovery. Two types of noise are studied: environmental (Gaussian white) noise and state-dependent demographic noise. The dynamical mechanism responsible for both phenomena is a transition from one stable steady state to another driven by stochastic forcing, mediated by an unstable steady state. Exploiting a generic and effective two-dimensional reduced model for real-world mutualistic networks, we find that the average transient lifetime scales algebraically with the noise amplitude, for both environmental and demographic noise. We develop a physical understanding of the scaling laws through an analysis of the mean first passage time from one steady state to another. The phenomena of noise-induced collapse and recovery and the associated scaling laws have implications for managing high-dimensional ecological systems.
Discrete and Probabilistic Classifier-based Semantics

We present a formal semantics (a version of Type Theory with Records) which places classifiers of perceptual information at the core of semantics. Using this framework, we present an account of the interpretation and classification of utterances referring to perceptually available situations (such as visual scenes). The account improves on previous work by clarifying the role of classifiers in a hybrid semantics combining statistical/neural classifiers with logical/inferential aspects of meaning. The account covers both discrete and probabilistic classification, thereby enabling learning, vagueness and other non-discrete linguistic phenomena.
Analogue neuro-memristive convolutional dropout nets

Randomly switching neurons ON/OFF while training and inference process is an interesting characteristic of biological neural networks, that potentially results in inherent adaptability and creativity expressed by human mind. Dropouts inspire from this random switching behaviour and in the artificial neural network they are used as a regularization techniques to reduce the impact of over-fitting during the training. The energy-efficient digital implementations of convolutional neural networks (CNN) have been on the rise for edge computing IoT applications. Pruning larger networks and optimization for performance accuracy has been the main direction of work in this field. As opposed to this approach, we propose to build a near-sensor analogue CNN with high-density memristor crossbar arrays. Since several active elements such as amplifiers are used in analogue designs, energy efficiency becomes a main challenge. To address this, we extend the idea of using dropouts in training to also the inference stage. The CNN implementations require a subsampling layer, which is implemented as a mean pooling layer in the design to ensure lower energy consumption. Along with the dropouts, we also investigate the effect of non-idealities of memristor and that of the network.
Eukaryotic Nuclear RNA Polymerases

INTRODUCTION The specific mechanisms involved in the regulation of transcription are largely unknown, but whatever their nature, they must directly or indirectly affect the activity of the DNA-dependent RNA polymerases involved in the transcription processes. To date, three structurally distinct classes of nuclear RNA polymerases have been identified and shown to have distinct transcriptive functions. Hence, the quantitative regulation of specific classes of genes may be effected by the cellular levels of distinct enzymes. Other mechanisms must be responsible for the differential transcription of a class of genes that are transcribed by a common enzyme. Considerable evidence now supports the hypothesis that chromatin structural modifications govern the accessibility of specific genes and hence their ability to be transcribed by an RNA polymerase. However, there may exist transcriptional controls, other than those imposed by chromatin structure or by RNA polymerase levels, that operate through specific RNA polymerases. Such controls might involve components that alter the interactions between a specific enzyme and a specific gene or genes. The primary interactions of such components could be either with the enzyme or with the template. Undoubtedly, the elucidation of the various regulatory mechanisms will require their reconstruction in cell-free systems from purified components. It seems probable, therefore, that it will become increasingly important to understand the structure, function and regulation of the eukaryotic RNA polymerases since these enzymes may be necessary for the specific transcriptional controls to be manifest in vitro as well as in vivo. This review will attempt to summarize, in a.
Can human amniotic membrane be used as an Ideal Suture or Filling Material? An Experimental study

Background: The use of the patient’s own tissues in surgery increases the morbidity rate, whereas the use of injected or implanted materials can cause allergic reactions in the body mostly via immunogenic pathways. In addition, absorbable suture materials and some fillers used in almost all surgical applications can cause reactions in the body. Objective: The use of human amniotic membrane (HAM) as a suture and/or filling material has been successfully investigated in many areas to solve or minimize these problems.
Fast visual grounding in interaction: bringing few-shot learning with neural networks to an interactive robot

The major shortcomings of using neural networks with situated agents are that in incremental interaction very few learning examples are available and that their visual sensory representations are quite different from image caption datasets. In this work we adapt and evaluate a few-shot learning approach, Matching Networks (Vinyals et al., 2016), to conversational strategies of a robot interacting with a human tutor in order to efficiently learn to categorise objects that are presented to it and also investigate to what degree transfer learning from pre-trained models on images from different contexts can improve its performance. We discuss the implications of such learning on the nature of semantic representations the system has learned.
Plant-virus-insect tritrophic interactions: insights into the functions of geminivirus virion-sense strand genes

The genome of the plant-infecting viruses in the family Geminiviridae is composed of one or two circular single stranded DNA of approximately 2.7–5.2 kb in length. These viruses have emerged as the most devastating pathogen infecting a large number of crops and weeds across the continents. They code for fewer open reading frames (ORFs) through the generation of overlapping transcripts derived from the bidirectional viral promoters. Members of geminiviruses code for up to four ORFs in the virion-sense strand, and their gene expression is regulated by various cis-elements located at their promoters in the intergenic region. These viral proteins perform multiple functions at every stage of the viral life cycle such as virus transport, insect-mediated virus transmission and suppression of host defence. They impede the host's multi-layered antiviral mechanisms including gene silencing (at transcriptional and post-transcriptional levels) and hypersensitive response. This review summarizes the essential role of virion-sense strand encoded proteins in transport of viral genomes within and between plant cells, countering defence in hosts (both plants and the insects), and also in the ubiquitous role in vector-mediated transmission. We highlight the significance of their pro-viral activities in manipulating host-derived innate immune responses and the interaction with whitefly-derived proteins. We also discuss the current knowledge on virus replication and transcription within the insect body.
Six-lncRNA Immune Prognostic Signature for Cervical Cancer

Background This study searched for immune-related long noncoding RNAs (lncRNAs) to predict the prognosis of patients with cervical cancer. Method We obtained immunologically relevant lncRNA expression profiles and clinical follow-up data from cervical cancer patients from The Cancer Genome Atlas database and the Molecular Signatures Database. Cervical cancer patients were randomly divided into a training group, testing group and combined group. The immune prognostic signature was constructed by Least Absolute Shrinkage and Selection Operator Cox regression, prognosis was analyzed by Kaplan–Meier curves between different groups, and the accuracy of the prognostic model was assessed by receiver operating characteristic-area under the curve (ROC-AUC) analysis. Results A six-lncRNA immune prognostic signature (LIPS) was constructed to predict the prognosis of cervical cancer. The six lncRNAs are as follows: AC009065.8, LINC01871, MIR210HG, GEMIN7-AS1, GAS5-AS1, and DLEU1. A ROC-AUC analysis indicated that the model could predict the prognosis of cervical cancer patients in different subgroups. A Kaplan–Meier analysis showed that patients with high risk scores had a poor prognosis; these results were equally meaningful in the subgroup analyses. Risk scores differed depending on the clinical pathology and tumor grade and were independent risk factors for cervical cancer prognosis. Gene set enrichment analysis revealed an association between the LIPS and the immune response, Wnt signaling pathway, and TGF beta signaling pathway. Conclusion Our study shows that the six-LIPS can predict the prognosis of cervical cancer and contribute to decisions regarding the immunotherapeutic strategy.