Miracle-dz/UniFAR-FTUs huggingface dataset:
MAPEAMENTO DE PROCESSOS UTILIZANDO BPM: ESTUDO APLICADO EM UMA INDÁSTRIA DE BENS DE CONSUMO

Em um cen├írio de mercado cada vez mais competitivo, as empresas s├úo impelidas a realizar pr├íticas de mapeamento e gerenciamento de processos buscando aumentar a efici├¬ncia e efic├ícia de seus resultados organizacionais. Desta maneira, eeste trabalho teve por objetivo apresentar um estudo que aplica a disciplina BPM ├á uma ind├║stria de bens de consumo visando a melhoria do processo de importa├o├úo de produtos acabados a partir da chegada e libera├o├úo dos produtos no porto. Elaborou-se o mapeamento do processo para mitigar falhas que atrasavam a execu├o├úo, impactavam o n├¡vel de servi├oo e a produtividade. Associou-se o uso de ferramentas anal├¡ticas com as pr├íticas sugeridas pela disciplina BPM, sendo elaborada uma proposta de redu├o├úo do tempo de processo e dos custos operacionais por meio da elimina├o├úo de retrabalhos e realoca├o├úo de processos.
Role of protein kinase C delta (PKCδ) in airway mucin secretion.

PARK, JIN-AH. Role of protein kinase C delta (PKCδ) in airway mucin secretion. (Under the direction of Dr. Kenneth B. Adler). Mucin hypersecretion is a prominent pathophysiologic feature of chronic airway diseases such as cystic fibrosis, asthma and chronic bronchitis. Exacerbated mucin secretion can lead to impaired mucociliary function, increased susceptibility to bacterial pathogens, potentiation of inflammatory responses, and, in extreme cases, death. Despite these deleterious effects, effective therapy to alleviate mucin hypersecretion remains to be developed. The intention of this work was to elucidate the mechanism of mucin secretion in response to secretagogues utilizing normal human bronchial epithelial (NHBE) cells in vitro. NHBE cells were maintained in air/liquid interface and allowed to differentiate into a normal airway epithelium containing mucin secreting (goblet), ciliated and basal cells. Mucin secretion was measured by an enzyme linked immunoabsorbent assay (ELISA) using antibodies recognizing specific mucin proteins (MUC5AC, MUC5B and MUC2) or pansecreted mucins. In manuscript one, we elucidate some aspects of the mechanism whereby human neutrophil elastase (HNE) enhances mucin secretion from NHBE cells. We found that HNE provokes mucin secretion in a concentration-dependent manner, with maximal stimulation (more than two-fold) occurring within a short (15 minute) time period. The mucins, MUC5AC and MUC5B, but not MUC2, were released in response to 500nM HNE. Myristoylated alanine-rich C-kinase substrate (MARCKS) is rapidly phosphorylated in response to HNE exposure (within 2 minutes), suggesting activation of protein kinase C (PKC) is involved in HNE-induced mucin hypersecretion. PKCδ was the only isoform to translocate from cytoplasm to membrane in response to HNE, and inhibition of PKCδ by a specific pharmacologic inhibitor (rottlerin) attenuated HNE-mediated mucin secretion. Therefore, we concluded that HNE induces mucin secretion via the activation of PKCδ in normal human bronchial epithelial cells in vitro. In manuscript two, we further investigated the role of PKCδ in mucin secretion. Selective activation of PKCδ by bryostatin 1 provoked mucin secretion and induced phosphorylation of MARCKS in NHBE cells. Suppression of PKCδ by rottlerin significantly attenuated HNE-or PMA-mediated mucin secretion as well as phosphorylation of MARCKS. A virally immortalized human bronchial epithelial cell line (HBE-1) was utilized for transient transfections. Transfection of HBE-1 cells with a dominant-negative PKCδ construct (pEGFP-N1/PKCδ) significantly attenuated PMA-induced mucin secretion and phosphorylation of MARCKS compared to cells transfected with empty vector (pEGFP-N1) alone. These results suggest that PKCδ regulates mucin hypersecretion in human airway epithelial cells. ROLE OF PROTEIN KINASE C DELTA (PKCδ) IN AIRWAY MUCIN SECRETION
ABORDAGEM DA APRENDIZAGEM DE MÁQUINA NO CONTEXTO DOS CUIDADOS À SAÚDE: UMA ANÁLISE BIBLIOMÉTRICA

Drienne Moreira Pazin (Universidade Federal de Mato Grosso do Sul ) drienne.pazin@gmail.com Gabriela Ribeiro Hencklein (Universidade Federal de Mato Grosso do Sul ) gabirh10@hotmail.com Darlene Pereira Pinto (Universidade Federal de Mato Grosso do Sul ) darlene.ufms@gmail.com Amanda Trojan Fenerich (Universidade Federal de Mato Grosso do Sul ) amanda.fenerich@gmail.com Mirian Batista de Oliveira Bortoluzzi (Universidade Federal de Mato Grosso do Sul ) mirianbortoluzzi@gmail.com
Phytochemical Screening and Antioxidant Activities of Leaf and Root Bark Extracts of Combretum paniculatum

Combretum paniculatum (combretaceae), has been used widely in ethno medicine in the treatment of chronic diarrhea and dysentery, flatulence, vomiting, colic, and enlarge spleen and liver. The leaf and root of C. paniculatum were pulverized and extracted by serial exhaustive method with solvents i.e chloroform, ethyl acetate and ethanol in order of increasing polarity, the extracts were investigated for their phytochemical composition and antioxidant activities. The results of the qualitative phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, steroids, phlobtannins and cardiac glycosides in both leaf and root extracts. The results obtained from quantitative phytochemical analysis shows that flavanoids has the highest yield of 21.00%, saponin 20.40%, alkaloids have the lowest percentage yield of 13.80%. The results of the Total Antioxxidant Porential (TAP) revealed that ethanol leaf extract has the highest total antioxidant activity (TAP) followed by ethanol root extract. After 90 minutes incubation, 80.2% of DPPH radicals were quenched by ethanol leaf extract.
Desarrollo profesional docente, trabajo colaborativo y Red Escolar: un estudio de caso del Comité de Educadoras de Párvulos de Lo Prado

El trabajo colaborativo docente se ha planteado como uno de los ejes que podría generar mayor impacto en el desarrollo profesional de los profesores, pues posibilitaría mejoras a través de la reflexión y el diálogo entre pares. Del mismo modo se investiga y retoma la idea del trabajo en comunidad, estableciendo Redes Escolares entre los centros para potenciar el trabajo contextualizado al entorno socio-cultural y laboral donde los docentes se desempeñan. El estudio realizado tuvo por propósito investigar, a partir de las percepciones de las propias educadoras, las dinámicas y características del trabajo colaborativo docente en el marco de la Red Escolar llamada Comité de Educadoras de Párvulos de lo Prado. Los resultados obtenidos se contrastaron con los postulados teóricos investigados. La metodología propuesta responde a un estudio de caso instrumental de corte mixto con diseño explicativo secuencial. La recolección de los datos se realizó a través de encuestas, entrevistas a agentes claves y análisis de documentos oficiales. Los resultados indican que muchos de los aspectos que propician y limitan el trabajo colaborativo docente son coincidentes con la literatura. Ahora, en la investigación aparecen dimensiones relacionadas con la emocionalidad y confianza, aspectos que nos hacen plantear otras variables de estudio enfocadas a ámbitos relacionales - emocionales, y cómo influyen y trascienden en la disposición técnica demandada y la real labor desarrollada.
Changes in the inline lactate dehydrogenase according to the cow’s production and reproduction status

The aim of the present study was to investigate inline lactate dehydrogenase (LDH) changes in clinically healthy dairy cows according to the number and stage of lactations, milk yield, and the reproduction status The LDH activity (μmol/min per litre) was measured using the dry-stick technology. A total of 378 cows were selected and classified according to their reproductive status into the following groups: fresh (1–44 days after calving); open (45–65 days after calving); inseminated (1–35 days after insemination); pregnant (35–60 days after insemination). According to their milk productivity, the cows were classified into the following groups: <15 kg/d, 15–25 kg/d, >25–35 kg/d, and >35 kg/d. They were milked with a DeLaval milking robot in combination with a Herd Navigator analyser. The results showed that the inline LDH concentration had a tendency to increase along with the increase in the number of lactation periods (P < 0.05). The highest level of LDH was observed in fresh cows 5–10 days in milk (DIM), and the highest LDH concentration was found in the milk of fresh cows. A positive statistically reliable relationship was found between the milk yield and LDH concentration (P < 0.05); LDH and milk somatic cell counts (SCC) were positively related in all groups of cows, although LDH concentration and SCC were the highest correlated variables in inseminated cows (P < 0.05). The present study shows that measuring LDH activity in milk is both easy and cost effective with high sensitivity and specificity, having a great potential as a diagnostic tool for detection of subclinical mastitis.
Progress and Challenges of Neuroscience and Brain-inspired Artificial Intelligence

Neuroscience and brain-inspired artificial intelligence are significant research areas. Many countries have launched brain-related projects in which neuroscience and brain-inspired artificial intelligence are major targeted areas to increase national interests and enhance their strength in key areas such as military and homeland security in the competitive global world. Methods, emerging technologies, and progress in neuroscience and brain-inspired artificial intelligence are introduced in this paper that specifically include brain-inspired computing, brain association graph, brain networks, the connectome, brain reconstruction, imaging technologies used for the brain, chips and devices inspired by the human brain, brain-computer interface or brain-machine interfaces, cyborg, neuro-robotics, and quantum robotics. Challenges in some of the topics are also presented and discussed.
Resilience as a coping strategy for reducing departure intentions of accounting students

ABSTRACT This study evaluates the influence of resilience as a potential coping strategy to help reduce student departure from the accounting major. We collected data from 443 accounting majors at four geographically disbursed U.S. universities using a battery of psychometric instruments. With these data, we analyzed the relations between role stressors, psychological health, burnout, and departure intentions, and assessed the extent to which individual resilience levels served as a positive influence by enhancing health, and diminishing burnout and departure intentions. We found sources of role stress to have significant negative associations with psychological health, and significant positive associations with academic burnout (direct), and departure intentions (indirect). However, resilience counteracted those associations through its direct positive association with psychological health, and direct negative association with burnout. Resilience also had a significant indirect negative association with departure intentions through its direct associations with psychological health (positive) and burnout (negative).
520 Summative process evaluation of a driver licensing support program in remote aboriginal communities

Background Aboriginal people in the Northern Territory (NT) have low rates of driver licensing, which is likely to contribute to high rates of transport-related injury, high rates of incarceration for regulatory driving offences and reduced access to employment, education and essential health services. The DriveSafe NT Remote program was implemented by the NT Government to increase driver licensing in remote communities. This evaluation reviews the program delivery, acceptability, implementation challenges and licensing outcomes. Methods A mixed-methods approach was used, incorporating program observation and key informant perspectives. Program data (collected April 2012 to June 2014) and de-identified licensing data from the NT Motor Vehicle Registry were analysed for trends in service delivery and licensing rates pre and post-program. Results Stakeholders reported that the program is meeting the needs of underserviced remote communities, and regarded the program as highly engaging and acceptable. There was a greater increase in new licences at intervention sites (Learner 24% and Open licence 18%) compared with other remote areas (Learner licence 13% and Open licence 8%). There appeared to be a dose response relationship with greater licence outcomes at communities that received higher levels of program delivery. Conclusions DriveSafe NT Remote is a Government delivered program that is acceptable to Aboriginal clients in remote NT communities, and is increasing driver licensing rates in these settings. The flexible delivery and culturally responsive approach should allow continuation of positive licensing outcomes.
Making the most of multiple worlds: Multiple organizational identities as resources in the formation of an integrated health care delivery system

In spite of an undeniably vast and multidisciplinary body of research on mergers and acquisitions (M&As) spanning more than 50 years, extant scholarship provides little insight into how two organizations that have struggled to integrate rebound from failure in their relationship. This dissertation examines two organizations—AMC Hospital and Community Hospital—that achieved this outcome nearly 16 years after they legally merged. To understand this phenomenon, I conducted an inductive, longitudinal qualitative study of these two organizations and their members using interviews, archival data, and observations as my data sources and grounded theory techniques to analyze the data and build theory. Extending prior research on M&As, multiple organizational identity management, and identities as resources in organizations, I advance the notion of multiple identity resourcing by examining how the negotiation of multiple organizational identities fostered greater resource sharing and generation during postmerger integration. Additionally, I elaborate prior research on meaning construction during strategic change by examining how managers’ interpretations of the power and intimacy dynamics in the merger relationship influenced their strategizing, which affected organizationallevel episodes of success and failure during the integration process. More broadly, I demonstrate how practices at both the level of the merger relationship and the level of strategy implementation enable successful performance during post-merger integration.
Nutritional Management of Canine Cancers and the Role of Nutritional Supplements

NUTRITIONAL MANAGEMENT OF CANINE CANCERS AND THE ROLE OF NUTRITIONAL SUPPLEMENTS Adriana Bianco University of Guelph, 2019 Advisor: Adronie Verbrugghe This thesis is an investigation of the dietary decisions made for pets by owners of dogs with cancer and owners of healthy dogs. In addition, an in vitro investigation of the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on canine osteosarcoma cells both as a single agent and in combination with doxorubicin was conducted. Owners of dogs with cancer were found to make different dietary decisions for their pets compared to owners of healthy dogs, especially with regards to diet type and use of nutritional supplements. DHA and EPA had antagonistic effects on doxorubicin and had variable effects as a single agent treatment. Further research is needed to determine the safety and efficacy of nutritional supplements. Greater emphasis is needed in veterinary practices on the importance of client and clinician communication to ensure dogs with cancer are provided a safe and healthy diet.
SIDE EFFECTS OF INTRAVENOUS GANCICLOVIR AND COMBINATION OF INTRAVENOUS GANCICLOVIR-ORAL VALGANCICLOVIR IN PEDIATRIC PATIENTS WITH CYTOMEGALOVIRUS INFECTION

Objective: Intravenous ganciclovir and oral valganciclovir are known to have severe side effects against hematopoiesis and kidney function. This study aims to look for these side effects in pediatric patients with cytomegalovirus (CMV) infection treated with ganciclovir or a combination regimen of both in Hasan Sadikin General Hospital, a tertiary care center in West Java, Indonesia. Methods: This was a cross-sectional study using medical records and laboratory examination data from pediatric patients with CMV infection who received ganciclovir of 6 mg/kg twice a day, valganciclovir of 16 mg/kg twice a day, or a combination of both in Hasan Sadikin General Hospital from January 2015 to January 2019. Differences before and after therapy were analyzed to look for any side effects in each regimen and duration of therapy. Results: Out of 115 patients, there were 53 subjects who met the research criteria. Majority of the subjects used a combination regimen (n=29, 55%) for 6 weeks (n=36, 68%). There was no statistically significant difference (p>0.05) in the incidence of anemia, neutropenia, thrombocytopenia, increase in creatinine serum, or increase in blood urea nitrogen for different regimen or duration of therapy. Conclusion: No side effects were found to be related with therapeutic regimen or duration of therapy in pediatric patients with CMV infection in this study.
Is Deploying a High Level of Entrepreneurial Orientation Always Crucial for Sustainable Growth of High-Tech Ventures? the Moderating Effects of Environmental Turbulence

A turbulent environment is a double-edged sword for new ventures to translate entrepreneurial orientation (EO) into sustainable growth. However, most of previous literature in strategic management and entrepreneurship mainly focused on overall effects of the turbulent environment and ignored the different moderating effects across environmental conditions. This study provides an important framework for exploring the relationships among EO, two potentially critical turbulent environment conditions (market turbulence and technological turbulence), and sustainable growth. Data were collected from 146 high-tech ventures in China. These firms ranged in size from 5 to 200 employees and averaged 46.8 employees. Moderated hierarchical linear regression analysis (MHLRA) was conducted to test the hypotheses about the direct effects of EO on sustainable growth as well as the moderating effects of two potentially critical environmental conditions (market turbulence and technological turbulence) on the EO-sustainable growth relationship.Consistent with previous findings, the results suggest that EO is universally beneficial for new ventures in achieving better sustainable growth. In the context of the moderating effects, this study shows no weakness in the relationship between EO and sustainable growth as a result of an increase in the level of market turbulence. On the other hand, our research shows the strengthening of the relationship as a result of an increase in the level of technological turbulence. The empirical results suggest that deploying a high level of EO should take into account the moderating effect of environmental turbulence. That is because a turbulent environment is a double-edged sword for new ventures to translate EO into sustainable growth.
Pain distribution in primary care patients with hip osteoarthritis

BACKGROUND Hip osteoarthritis (OA) is the most common diagnosis in primary care adult patients presenting with hip pain but pain location and pain distribution in primary care patients with hip OA have been reported inadequately. OBJECTIVE To describe pain location and pain distribution in primary care patients with clinical and radiographic confirmed hip OA. METHODS Primary care patients with unilateral clinical and radiographic hip OA living on the island of Funen, Denmark were recruited from primary care to participate in a randomized clinical trial. At baseline, patients recorded pain intensity using an 11-box numeric rating scale and the distribution of hip pain using a manikin displaying three separate views: front, back and lateral. Pain drawings were analysed using a template to determine the most frequent pain locations and distribution of pain. RESULTS Pain drawings were completed by 109 patients of which 108 (99%) were valid. The mean age of patients was 65 (SD 9) years and 44% were females. The mean pain intensity was 5.4 (SD 2.0). A total of 77% had marked the greater trochanter area, 53% the groin area, 42% the anterior/lateral thigh area, 38% the buttock area, 17% the knee and 15% the lower leg area. No patients marked pain exclusively in the areas of the knee, posterior thigh or lower leg. CONCLUSION The most common pain locations of patients with hip OA presenting to primary care are the greater trochanter, groin, thigh and buttock areas. No patients recorded pain exclusively in the knee or lower leg.
VALUE CHAIN STUDY OF PAPUA NUTMEG IN FAKFAK DISTRICT

Nutmeg is the main commodity at the Fakfak district of Papua in the agriculture subsector. Yet, the farmers have not been able to enjoy optimal added value from production results. Some of the problems included are pricing, developing derivative products and market access. The purpose of this study is to map the nutmeg value chain in the Fakfak district by understanding the characteristics of actors influencing the chain and the potential for its development. This study uses a qualitative approach with the main instrument of interviews used in data collection techniques. The results showed that actors involved in the nutmeg value chain are seed suppliers, farmers, local collectors, BUMKAM (village enterprise), IRT (home industry), inter-island traders and cooperatives. The use of nutmeg meat has become a potential in increasing the added value of processed nutmeg products in Fakfak District.
Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells

Microbiota within mosquitoes influence nutrition, immunity, fecundity, and the capacity to transmit pathogens. Despite their importance, we have a limited understanding of host-microbiota interactions, especially at the cellular level. It is evident bacterial symbionts that are localized within the midgut also infect other organs within the mosquito; however, the route these symbionts take to colonize other tissues is unknown. Here, utilizing the gentamicin protection assay, we showed that the bacterial symbionts Cedecea and Serratia have the capacity to invade and reside intracellularly within mosquito cells. Symbiotic bacteria were found within a vacuole and bacterial replication was observed in mosquito cell by transmission electron microscopy, indicating bacteria were adapted to the intracellular milieu. Using gene silencing, we determined that bacteria exploited host factors, including actin and integrin receptors, to actively invade mosquito cells. As microbiota can affect pathogens within mosquitoes, we examined the influence of intracellular symbionts on Zika virus (ZIKV) infection. Mosquito cells harbouring intracellular bacteria had significantly less ZIKV compared to uninfected cells or cells exposed to non-invasive bacteria. Intracellular bacteria were observed to substantially upregulate the Toll and IMD innate immune pathways, providing a possible mechanism mediating these anti-viral effects. Examining mono-axenically infected mosquitoes using transmission electron and fluorescent microscopy revealed that bacteria occupied an intracellular niche in vivo. Our results provided evidence that bacteria that associate with the midgut of mosquitoes have intracellular lifestyles which likely have implications for mosquito biology and pathogen infection. This study expands our understanding of host-microbiota interactions in mosquitoes, which is important as symbiont microbes are being exploited for vector control strategies.