Miracle-dz/UniFAR-FTUs huggingface dataset:
New substrates and functions of PP2A-Cdc55 phospatase in the mitotic exit

La sortida de mitosis compren tots els processos de la mitosis que van des de la segregacio de les cromatides germanes a l’obtencio de dues cel·lules filles geneticament identiques. A nivell molecular, les cel·lules inicien diversos processos per inactivar la Cdk mitotica, requisit imprescindible per acabar la mitosis i entrar en la seguent fase G1. La sortida de mitosis en el llevat de gemmacio, S. Cerevisiae, s’inicia amb l’activacio del complex promotor d’anafase APCCdc20 i l’activacio de la fosfatasa Cdc14. Dues rutes complementaries i sequencials, FEAR (de l’angles Cdc14 early anaphase release) i MEN (de l’angles mitotic exit network), promouen l’alliberament i activacio de la fosfatasa Cdc14 durant l’anafase, la qual es considera clau per eliminar l’activitat mitotica de Cdk1 i sortir de mitosis. La fosfatasa Cdc14 es mante segrestada al nucleol durant la resta del cicle cel·lular mitjancant la seva unio a la proteina nucleolar Net1. A l’inici de l’anafase, la proteasa separasa hidrolitza el complex de cohesina, desencadenant aixi la separacio de les cromatides germanes i, alhora, coopera amb Zds1 per promoure la inhibicio de la fosfatasa PP2ACdc55. La caiguda d’activitat PP2ACdc55 facilita la fosforilacio de Net1 dependent de Cdk1, promovent aixi que Cdc14 s’alliberi al nucli. La quinasa polo, Cdc5, contribueix en aquest proces. A mesura que l’activitat mitotica de Cdk1 disminueix, degut a l’accio d’APCCdc20 degradant ciclines mitotiques i l’activitat de Cdc14, les cel·lules activen la ruta MEN per mantenir Net1 fosforilat i Cdc14 actiu fins al final d’anafase. La ruta de MEN compren la GTPasa Tem1, i les quinases Cdc15 i Mob1-Dbf2. L’inici de la ruta esta regulat pel complex Bfa1-Bub2, que mante Tem1 inactiu fins l’anafase, i per Lte1, que promou l’activacio de Tem1. Un cop activa, la ruta de MEN allibera Cdc14 al citoplasma, on permet l’acumulacio de l’inhibidor de Cdk1, Sic1, i on tambe activa el complex APCCdh1, el qual finalitza amb la degradacio de les ciclines mitotiques. Per tant, la completa activacio de Cdc14 al final de l’anafase promou la inactivacio de Cdk1 i contraresta les fosforilacions mitotiques d’aquesta, permetent aixi la sortida de mitosis i entrada a G1. Com la cel·lula coordina la segregacio cromosomica amb la inactivacio de la Cdk mitotica es de gran interes, doncs errors en aquest proces provoquen la mort cel·lular. Aixi doncs, la descripcio detallada dels mecanismes moleculars que regulen la sortida de mitosis tenen un gran potencial pel disseny de futures terapies contra el cancer. El treball que es presenta en aquesta tesis doctoral aprofundeix en el paper de la fosfatasa PP2ACdc55 en la sortida de mitosis, fosfatasa que esta emergent com a regulador clau del cicle cel·lular en organismes superiors. Resultats previs del grup suggereixen la implicacio de la fosfatasa PP2ACdc55 en la iniciacio de la ruta MEN i d’altres possibles funcions. OBJECTIUS 1. Descriure el paper de la fosfatasa PP2ACdc55 en la regulacio de la ruta MEN 2. Identificar nous possibles substrats i funcions de la fosfatasa PP2ACdc55 mitjancant un screening proteomic.
Social Intelligence of Adolescents: A Study of Himachal Pradesh

Abstract This study was to find out the social intelligence of adolescents and the correlation between ecological variables and social intelligence of the respondents. A study was conducted in Kangra District of Himachal Pradesh. Two blocks namely Panchrukhi and Bhawarna were randomly selected. Four schools were selected from each block. Survey was done on 200 adolescents falling in the age group of 13-19 years under each block. Social Intelligence was assessed by Social Intelligence Scale. The results of the study revealed that most of males and females respondents were with optimistic social intelligence dimensions such as patience, co-operativeness and confidence. Contrary to this, high percentage of males and females respondents showed negative response of social intelligence dimensions such as recognition of social environment, tactfulness and sense of humour. But, males and females respondents showed an affirmative relationship with memory. A significant correlation was found between social intelligence dimensions and ecological variables of respondents.
Comparative Phytochemical Profiling of Clerodendrum infortunatum L. Using GC-MS Method Coupled with Multivariate Statistical Approaches

Clerodendrum infortunatum L. is extensively used in traditional and folklore medicine. It has also been recognized in Ayurveda and Unani medicinal systems. Different pharmacological properties of C. infortunatum have already been reported. However, the phytochemical constituents remained unknown. Thus, the present study was performed to investigate and compare the phytochemical composition of the major parts of C. infortunatum using gas chromatographymass spectrometry. GC-MS is one of the most reliable biophysical method for its specificity and repeatability, was utilized for the phytochemical profiling C. infortunatum leaf, stem, root, flower and seed. The phytochemical profiles were further compared using multivariate statistical techniques to evaluate the extent of analogy between the phytochemical profiles. Several bioactive chemical species such as limonene, phytol, catechol, hexadecanoic acid, squalene, dodecanoic acid, vitamin E, hydroxymethylfurfural, stigmasterol, etc. were identified in different parts of C. infortunatum. Derivatives of pharmacological supplements such as cinnamic acid, guaiacol, eugenol, vanillic acid, vitamin D etc. were also detected. Moreover, a wide range of phenolics and phenolic acid derivatives were identified in C. infortunatum, which are known to be primarily responsible for bioactivities of herbal medicines. Principal component analysis coupled with hierarchical clustering revealed the extent of correlation and divergence among the major parts of C. infortunatum in terms of phytochemical fingerprints. Flower, leaf and root demonstrated equivalent phytochemical fingerprints.The results provided insights into the presence of several pharmacologically active constituents. The pattern of phytochemical correlation between leaf, stem, root, flower and seed was established as well.
The Influence of Translation Techniques on the Accuracy and Acceptability of Translated Utterances that Flout the Maxim of Quality

Translating the implied meanings in utterances is one of the trickiest situations translators may confront. One example is in translating utterances that flout the maxim of quality. When a speaker flouts the maxim of quality, they are implying further information that is not represented in the utterance. Translators use various translation techniques in order to convey the meaning of the original text in the most appropriate and acceptable form in the target text. This study investigates how translation techniques may affect the quality of a translation. The approach implemented in this study is pragmatics in translation. This study belongs to the field of descriptive qualitative research with an embedded case study. For data, we look at all the utterances which may be said to be flouting the maxim of quality in the source text and its translation. Content analysis and focus group discussion were applied as the methods to collect and analyze the data. A focus group discussion was used to assess translation quality. The majority of the data was classified as accurate and acceptable, while the rest was considered less accurate and inaccurate due to the application of the translation technique amplification (addition), discursive creation and literal translation. Some data was also found to be less acceptable due to literal translation and pure borrowing.
BAYESIAN NONPARAMETRIC DURATION MODEL WITH CENSORSHIP

This paper is concerned with nonparametric i.i. d. durations models censored observations and we establish by a simple and unified approach the general structure of a bayesian nonparametric estimator for a survival function S. For Dirichlet prior distributions, we describe completely the structure of the posterior distribution of the survival function. These results are essentially supported by prior and posterior independence properties.
Clusters from the Inside and Out: Local Dynamics and Global Linkages

This paper surveys some of the current methodologies employed to analyse cluster development, as well as some of the key themes emerging from both the analytical and prescriptive literature noted above. It uses this survey as the context in which to present a synthesis of the initial findings of the current national study of industrial clusters in Canada, conducted by the Innovation Systems Research Network. The national study comprises 26 cases which aim to identify the presence of significant concentrations of firms in the local economy and to understand the process by which these regional-industrial concentrations of economic activity are managing the transition to more knowledge-intensive forms of production. The central questions in each case are: What role do local institutions and actors play in fostering this transition? How important is interaction with non-local actors in this process? How dependent are local firms on unique local knowledge assets and what is the relative importance of local versus non-local knowledge flows between economic actors? How did each local industrial concentration evolve over time to reach its present state and what key events and decisions shaped its path? And, finally, to what extent do these processes, relationships and local capabilities constitute a true cluster? Ultimately, what are the key relationships, linkages and processes that ground the cluster in its existing location?
Mine detection using the EMIR ® method - Improved configuration using a mobile detection system

Traditional way of metallic mine detection by magnetic techniques are often efficient; however, many methods have been experimented in order to detect any kind of mine even those made in plastic with no convincing result. We propose to adapt to that issue the EMIR ® method, already used in many other applications. Following preliminary results presented at QIRT 2002, a mobile detection system is evaluated leading to better images of buried mines or mine surrogates.
Quantification of oxygen turnover in groundwater by continuous on-site gas concentration measurements

We developed a stand-alone system based on a membrane inlet mass spectrometer (MIMS) for measuring dissolved gas concentrations in groundwater under field conditions. The system permits the concentrations of dissolved gases (He, Ar, Kr, N2, and O2) in groundwater to be determined quasi-continuously (every 12 min) with a precision of better than 4% for He and Kr, and with a precision of 1% for Ar, N2 and O2 in air-saturated water. The detection limits are below 3 ×10−9 cmSTP/g for the noble gases and below 400 ×10−9 cmSTP/g for N2 and O2. The results of a first deployment of the system in the field indicate that changes in the concentration of Ar that result from diel fluctuations of 3 °C in the river water temperature was still able to be resolved in groundwater, although the corresponding temperature signal almost vanished.
Development of cm-scale Wall Climbing Hexapod Robot with Claws

In this paper, we investigate the slip condition on a vertical wall surface and propose a cm-scale hexapod robot with claws that can climb the vertical wall. Since the volume force such as gravity is proportional to the length cubed and the area force such as muscle force is proportional to its cross section, i.e., the length squared, an object is more capable of overcoming gravity the smaller it is. This scaling effect allows a small robot to fly easily, accelerate rapidly, and climb a vertical wall with minimal difficulty. We developed a claw-type hexapod robot with a body length of 8.5cm and weight of 13.5g and realized horizontal and vertical movement on a vertical wall. In addition, we used a mathematical model and an experimental result to analyze the relationship between the gripping ability of the claws and the surface properties of the wall.
Veri Madenciliği Yöntemleri ile Kurumsal E-Öğrenme Başarı Modeli Geliştirilmesi

The dynamic and more demanding nature of today’s life conditions force people and corporations to invest in life-long education. It is important to make this continuous learning process more affordable and accessible to larger groups of people. At this point, e-learning seems to be more convenient way of learning than formal education especially for working adults because of their time and place constraints and their need for flexibility. The crucial concern is whether the e-learning process is useful or not and under what conditions it brings more value to adult learners. Thus, the core research question guiding this study is: What are the most significant factors influencing corporatee-learning success? The study aims to answer this question by developing e-learning success models via data mining. After a number of data preprocessing activities, a combination of descriptive and predictive data mining methodologies are applied on the data set. Most of the independent factors (learner demographics, learner experience, and course characteristics) are discovered to have power at different levels for explaining variance in e-learning success. Course program characteristics like content type, existence of certification are explored having a strong influence on the success of e-learning process.
Long Term Protease Inhibitor Monotherapy in a Two-Tiered HIV-1 LevelsDesign

Treatment of choice in ART therapy for HIV-1 viremia remains an issue as all treatments interrupt HIV repopulation albeit at different reproductive points. The issue was addressed by grouping patients into two-tiered HIV level design of High >50,000 and Low 75 cps/ml). In that adherence/non-adherence to regimen is a confound, it was also assessed by rate of suppression: HIVj-HIVk/ HVj-HVn. In the High group, one patient attained long term controlled HIV viremia over 56 months vs. 3 months of uncontrolled viremia while the other two patients (21 vs. 25; 9 vs. 11) did not. Corresponding values in Group 2 ranged from 6 months to 139 months vs. <5 months A t-test for correlated means (with control for duration differences) showed significant difference: t=4.10, α=<0.01, df=10. Suppression rates, both within and across groups, were from: 0.99-1.0 of cps/ml. Accordingly, PI monotherapy can maintain long term viremia suppression for viral levels of <50,000 cps/ml and ART is operative within an inferred functionally closed boundary system as no host characterization including CD4 T cell level affected ART outcome.
Quantitative Model for Predicting the Referential Intention of Construction Management Services

AbstractMany companies pay a great deal of attention to existing customers’ referral intentions when they attempt to attract new customers. However, little is known about the necessary level of satisfaction of existing customers to understand when existing customers are likely to complete a referral and by what mechanism. This study assumed referral routes and established a model for predicting referral intentions based on the satisfaction level as described by the disconfirmation of expectation theory and the net promoter score theory. Then, the routes were verified by surveying 103 construction management (CM) clients using structural equation modeling, and the prediction model was tested by applying it to 194 CM clients using multinomial logistic regression. The results indicated that the accuracy rate of the prediction model was 79.3%. This model can be used effectively to attract new clients, particularly in fields where long-term services are provided, such as CM, because it allows service providers.
Robert Hillestad: A Textiles Journey

Robert Hillestad uses the metaphor of journey to trace the evolution of his illustrious career as a textiles artist and design educator. His autobiographical essay provides insights into the origins of his fascination with textiles during early childhood and then recounts the critical steps in the evolution of his artistry and career through formal academic programs, various positions in business and industry, and a year-long study of fashion design in the haute couture of Paris, then focuses on his long and distinguished career as a design educator at the University of Nebraska-Lincoln. In addition to his narrative, the ninety-six-page monograph designed by Dika Eckersley features essays by Jo Ann C. Stabb and Beverly Gordon, scholars in the field of costume and textiles; a poem by Mary Logue; and lavish photography by John Nollendorfs, Roger Bruhn, John Spence, and Richard Hay. Robert Hillestad: A Textiles Journey is published by the Friends of the Robert Hillestad Textiles Gallery, a not-for-profit organization that supports the gallery named in Hillestad's honor. By capturing the essence of Hillestad's artistic footprint, the book prompts readers to embark on their own fantastical journey through his kinetic, multilayered, and highly regarded art. Although images of his artwork and references to his life and career appear in numerous publications in both print and electronic media, this is the first comprehensive publication focusing solely on Hillestad's background and artwork.
Anterior-Posterior Polarity in Caenorhabditis elegans: Establishment of Asymmetries at the One-Cell Stage and Beyond

The Caenorhabditis elegans one-cell embryo is a model system for understanding how cells are polarized during development. Polarity establishment is regulated with the cell cycle and involves sperm donated products and changes in the actomyosin cytoskeleton. Sperm entry results in completion of meiosis II in the embryo and the sperm donated centrosome polarizes the axis by triggering local destabilization of the cortical actomyosin cytosketon. This leads to cortical flows and localization of the cortical PAR proteins to distinct domains. Following the establishment of cortical polarity, the cytoplasm is polarized through protein movement and selective degradation of developmental regulators. The establishment of polarity in C. elegans is complete prior to the first cell division and is crucial for cell fate decisions in daughter cells. Further AP polarities in the embryo require cell-cell communication and the Wnt signaling pathway plays a pivitol role in many of the AP cell fate decisions throughout development.
Human Capital Heterogeneity: University Choice and Wages

This paper analyzes the impact of post-secondary education on wages in Israel. The focus is on the impact of university choice on individual wages controlling for the degree acquired and the area of study. Although the raw data indicate that universities command a different return to education, the paper shows that this is due to the selection of more able individuals to particular universities and not to differences in the quality of education offered. The paper is based on a unique data set linking the 1995 census of population, the universities’ records, and the Manufacturing and Crafts Survey.
A Compact Array Antenna: Explicit Design for C and X Band Applications

A novel and compact design of a circularly polarized slot antenna (CPSA) is elaborated. With the aim of generating CP feature and enhancing the impedance bandwidth, four rectangular stubs are wisely embedded in the antenna feed line structure and slotted ground plane to excite two orthogonal E vectors. Subsequently, a suitable arrangement of CPSAs in the form of 2 × 2 and 4 × 4 array antennas provokes higher functionalities in C and X band applications, respectively. Sequentially rotated (SR) feed technique is adopted to excite the antenna structure in array configurations. Measured and simulated results confirm outperformance of the array antennas with respect to the previously proposed designs. Compact size, wider impedance and axial ratio (AR) bandwidth, higher gain, and suitable radiation characteristics, both in single and array configurations, confirm suitability of the proposed designs for communication systems.
Effect of the anchoring group in porphyrin sensitizers: phosphonate versus carboxylate linkages

Porphyrins are an important family of organic chromophores that have attracted attention as photosensitizers in TiO2-based dye-sensitized solar cells (DSSCs). This brief review is dedicated to comparative studies of phosphonic and carboxylic acid anchoring groups for attachment of porphyrin sensitizers on semiconductors or conductors surface. Here we have selected some representative examples of recently described phosphonate/carboxylate porphyrins with the aim to demonstrate that porphyrin phosphonate should be a promising anchoring group for such systems.
Study on Bubble Velocity under Bubble Flow Scenario in the Horizontal Water Transmission Pipeline

Water Transmission Pipeline Zhu Yan , Wu Chenguang and Yuan Yixing School of Municipal and Environmental Engineering, Harbin Institute of Technology, 73 Huanghe Road, Harbin, China. School of Municipal and Environmental Engineering, Harbin Institute of Technology, 73 Huanghe Road, Harbin, China. School of Municipal and Environmental Engineering, Harbin Institute of Technology, 73 Huanghe Road, Harbin, China. ifengtian@126.com, wu.c. g@126.com, yyx1957@163.com
Nanofiltration Membrane Pore Diameter Determination

Se presenta un metodo para determinar el diametro de poro y transporte efectivo de masa a traves de membranas, empleando una mezcla de oligosacaridos. Los resultados se comparan con la ecuacion de Maxwell-Stefan. Los coeficientes de particion de los solutos son funcion del tamano de poro, de acuerdo con la ecuacion de Ferry. El diametro de poro se determina como unico parametro desconocido, el rechazo y el diametro de poro se obtienen mediante el procedimiento de optimizacion de Marquardt-Levenberg
Three-dimensional object location and inversion of the magnetic polarizability tensor at a single frequency using a walk-through metal detector

A tomographic metal detection and characterization system has been designed and built for recovering information about magnetic and/or conductive objects within the detector space. This information is gathered as a result of a ‘walk-through’ scan of a candidate in the same manner as for a typical security metal detector archway. Following the passage of the candidate, the system uses measurements from an array of coils to calculate the polarizability tensor, which describes the low frequency electromagnetic characteristic of a small metallic object when it interacts with an ac magnetic field. In addition to the magnetic polarizability dyadic tensor, the position of the perturbation is also determined as a product of the inversion algorithm. The system has been tested and is capable of inverting object tensors with <20% typical parameter variation, and determines three-dimensional object location with a typical error of less than ±3 cm. In this paper, results are shown from a set of four different test object examples, each with a different magnetic polarizability tensor. This object set consists of a ferrite sphere, a ferrite rod and phantom aluminium and steel handgun shapes.