Miracle-dz/UniFAR-FTUs huggingface dataset:
A two-year prospective study of treatment compliance in patients with schizophrenia

Synopsis The study is a prospective investigation of the factors associated with treatment compliance in 61 patients discharged from hospital with a ward diagnosis of schizophrenia. All cases were classified using reliable diagnostic criteria and all were followed up for two years. Compliance was assessed by inspection of records and by analysis of urine. Sociodemographic factors and illness variables were unrelated to compliance. Some aspects of a patient's insight and attitude, namely, a belief that medication had helped during the admission, a stated willingness to take treatment after discharge and a generally optimistic outlook, were associated with improved compliance. Other variables which showed such an association were the absence of the drug side-effect akinesia, good previous compliance and voluntary, as opposed to compulsory, admission to hospital.
Evolução das posturas corporais de estudantes em apresentações de seminários ao longo do semestre: uma análise utilizando dados multimodais e técnicas de clusterização

The present paper describes a clustering based approach to identify the main corporal patterns in students oral presentations during a given course. Data from 43 students presentations was collected through the use of Microsoft Kinect. The 16 collected features were used as input information in the clusterization process allowing the identification of three main profiles of presenters: passive, active, and semi-active. An analysis of the evolution of these profiles during the semester points out a decrease in the percentage of the passive profile throughout the course, and an increase in the percentage of the semi-active profile. These different profiles will be integrated into the system that collects the postures information in order to allow the automated classification of the presenters in real time. Resumo. O presente trabalho apresenta uma abordagem baseada em clusterização para identificar os principais padrões corporais em apresentações orais de estudantes em uma disciplina. Utilizando o Microsoft Kinect, foram coletados dados de 43 apresentações de estudantes realizadas em três momentos distintos ao longo do semestre. As 16 caracterı́sticas coletadas pelo sistema desenvolvido foram utilizadas como entrada para a clusterização que permitiu identificar três perfis principais de apresentadores: passivos, ativos e semiativos. Uma análise sobre a evolução desses perfis aponta que houve uma diminuição do percentual do perfil passivo ao longo do semestre e um aumento do percentual do perfil semi-ativo. Esses tipos de perfis serão integrados ao sistema de coleta de posturas para a futura classificação automática dos apresentadores em tempo real. 1. Introdução Bons comunicadores demonstram suas habilidades de apresentação com caracterı́sticas verbais e não verbais, como a linguagem corporal, o contato visual com a audiência, ou DOI: 10.5753/cbie.sbie. 2018.1483 1483 Anais do XXIX Simpósio Brasileiro de Informática na Educação (SBIE 2018) VII Congresso Brasileiro de Informática na Educação (CBIE 2018)
Influential Factors on the Awareness of Agile Software Development Methodology: A Systematic Literature Review

Agile software development methodology has been implemented by software industries over a decade ago and well accepted in the practitioner community. However, there is limited understanding on how agile practitioners aware towards implementation of agile practices in software development. Lack of awareness will lead to misunderstandings among agile practitioners and misuse the agile practices. In order to understand the awareness of agile practices, this paper aims to investigate the factors that affect awareness of agile practitioners in implementing agile practices. A systematic literature review (SLR)was conducted in order to classify and define the factors of awareness in agile software development methodology. The review was based on papers between 2002 and December 2014 from seven electronic databases. The relevant papers were included 20 journal articles, 24 conference papers,16 book chapters, 9 workshop papers.Consequently, 69 papers were identified that closely related with awareness in agile software development methodology. From the thematic analysis, 13 factors were classified from 42 elements. Based on the review result, understanding the influential factors on the awareness of agile practices will provide benefit to researchers and agile practitioners.
Quantitative expression analysis and prognostic significance of the novel apoptosis-related gene BCL2L12 in colon cancer

Abstract Apoptosis is a tightly regulated process that plays a critical role in many biological events. Members of the BCL2 (Bcl-2) family of apoptosis-related genes have been found to be differentially expressed in various malignancies and have been proposed as prognostic tumor biomarkers. We have recently discovered and cloned a new member of the BCL2 gene family, BCL2L12, expressed in colon tissues. Here we have investigated expression of the BCL2L12 gene in colon cancer tissues and assessed its prognostic value. Total RNA was isolated from 96 specimens of malignant colon tissue. After testing the RNA quality, cDNA was prepared by reverse transcription. A highly sensitive real-time PCR method for BCL2L12 mRNA quantification was developed using SYBR® Green chemistry. GAPDH served as a housekeeping gene. Relative quantification analysis was performed using the comparative CT method (2-ΔΔCT). High BCL2L12 expression levels were found in smaller (≤5 cm, p=0.027) and well-differentiated tumors (p=0.034), as well as in early-stage tumors (p=0.039). Survival analysis demonstrated that patients with BCL2L12-positive colon tumors have significantly longer disease-free survival and overall survival (p=0.015 and p=0.027, respectively). Our results suggest that BCL2L12 gene expression may represent a potential new biomarker for colon cancer.
Synthetic Riboswitches That Induce Gene Expression in Diverse Bacterial Species

Shana Topp, Emory University Colleen M. K. Reynoso, Emory University Jessica C. Seeliger, University of California, Berkeley Ian S. Goldlust, Emory University Shawn K. Desai, Emory University Dorothee Murat, University of California, Berkeley Aimee Shen, Stanford University Aaron W. Puri, Stanford University Arash Komeili, University of California, Berkeley Carolyn R. Bertozzi, University of California, Berkeley
Driving simulator and neuropsychological testing in OSAS before and under CPAP therapy

Patients with obstructive sleep apnoea syndrome (OSAS) have an increased car accident rate. Investigations on accident frequency are based on case history, insurance reports and driving simulator studies. The present study combines neuropsychological testing of different attention aspects engaged in driving a car and driving simulation to evaluate a suitable instrument for assessing therapeutic effects of continuous positive airway pressure (CPAP). Driving simulator investigation and neuropsychological testing of alertness, vigilance and divided attention were performed in 31 patients with polysomnographically confirmed OSAS (apnoea–hypopnoea index 24.8±21.5·h−1) before, and 2 and 42 days after initiation of CPAP. Divided attention and alertness improved significantly during CPAP, whereas vigilance remained unchanged. However, accident frequency (OSAS before therapy: 2.7±2.0; 2 days after CPAP: 1.5±1.4; 42 days after CPAP: 0.9±1.3) and frequency of concentration faults (OSAS before therapy: 12.4±5.1; 2 days after CPAP: 6.5±3.9; 42 days after CPAP: 4.9±3.3) decreased in the simulated driving situation after 2 and 42 days of therapy. There was no relation between accident frequency, concentration faults and daytime sleepiness, as measured by the Epworth Sleepiness Scale, and polysomnographic or neuropsychological findings, respectively. In conclusion, the present results suggest that driving simulation is a possible benchmark parameter of driving performance in obstructive sleep apnoea syndrome patients.
Modulation of the Electrophysiologic Actions of E-4031 and Dofetilide by Hyperkalemia and Acidosis in Rabbit Ventricular Myocytes

Background: E-4031 and dofetilide are new class III antiarrhythmic agents that inhibit the rapid component of the delayed rectifier potassium channel (IKr); however, the effectiveness of many antiarrhythmic drugs in ischemic conditions is uncertain. Methods and Results: We modeled two components of ischemia, hyperkalemia (9.6 mM) and acidosis (pH 6.8), in voltage-clamped single rabbit ventricular myocytes to help deter mine the effect of ischemia on the action of these two drugs. In physiologic solution both E- 4031 and dofetilide blocked IKr and significantly reduced total outward current. In hyper kalemic solution, both E-4031 and dofetilide showed significantly reduced blockade of IKr, while in acidotic solution dofetilide showed significantly reduced blockade of IKr and E-4031 showed a trend to reduced blockade. Neither drug significantly reduced total outward current in hyperkalemic or acidotic solutions. Conclusions: In these conditions, E-4031 and dofetilide demonstrate reduced blockade of I Kr, resulting in loss of class III effect. Furthermore, the complete loss of blocking effect on total outward current during simulated ischemia suggests increases of other repolarizing cur rents also contribute to loss of class III effect.
Evolutionary action maps for navigating a robot in an unknown, multidimensional, stationary environment. II. Implementation and results

Here, the BGM that is suggested in the first part of this paper used to construct a complete path planner for an agent of arbitrary shape that is operating in a totally unknown, multidimensional, stationary environment. The planner does not require any a priori knowledge about the environment to guarantee that a path to the target will be found. Any a priori information about the environment, regardless of its degree of fragmentation or sparsity, can be integrated into the planning process to accelerate convergence and enhance the quality of the path. Details for constructing the planner along with experiments to demonstrate its capabilities are supplied.
Microsatellite status and immunohistochemical features of ovarian clear-cell carcinoma.

BACKGROUND Ovarian clear-cell carcinoma (OCC) is known to have a poor prognosis and selected genetic features of OCC remain unknown. We investigated microsatellite instability (MSI) and the expression of the DNA mismatch repair-related protein, p53. MATERIALS AND METHODS MSI was examined by polymerase chain reaction using mono-, di-, tri- and tetranucleotide repeat markers, and hMSH2, hMLH1, hMSH6, MSH3 and p53 were determined immunohistochemically in 24 cases of OCC. RESULTS A total of 9 (37.5%) cases exhibited MSI. Two cases (8.3%) exhibited MSI-H in mononucleotide repeat loci with the negative expression of hMLH1, while another 7 cases (29.2%) exhibited selected trinucloetide repeat MSI (MSI-TR). Of these MSI-TR cases, 4 cases (57.1%) were determined to be negative for MSH3, while hMSH2, hMSH6, MSH3 and p53 expressions were normal. CONCLUSION Our findings suggest that MSI-TR would be a feature indicating the microsatellite status in OCC, and that the loss of MSH3 expression may promote MSI-TR.
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.

Abnormal elevation of plasma methionine may result from several different genetic abnormalities, including deficiency of cystathionine beta-synthase (CBS) or of the isoenzymes of methionine adenosyltransferase (MAT) I and III expressed solely in nonfetal liver (MAT I/III deficiency). Classically, these conditions have been distinguished most readily by the presence or absence, respectively, of elevated plasma free homocystine, detected by amino acid chromatography in the former condition, but absent in the latter. During the present work, we have assayed methionine, S-adenosylmethionine, S-adenosylhomocysteine, total homocysteine (tHcy), cystathionine, N-methylglycine (sarcosine), and total cysteine (tCys) in groups of both MAT I/III- and CBS-deficient patients to provide more evidence as to their metabolite patterns. Unexpectedly, we found that MAT I/III-deficient patients with the most markedly elevated levels of plasma methionine also had elevations of plasma tHcy and often mildly elevated plasma cystathionine. Evidence is presented that methionine does not inhibit cystathionine beta-synthase, but does inhibit cystathionine gamma-lyase. Mechanisms that may possibly underlie the elevations of plasma tHcy and cystathionine are discussed. The combination of elevated methionine plus elevated tHcy may lead to the mistaken conclusion that an MAT I/III-deficient patient is instead CBS-deficient. Less than optimal management is then a real possibility. Measurements of plasma cystathionine, S-adenosylmethionine, and sarcosine should permit ready distinction between the 2 conditions in question, as well as be useful in several other situations involving abnormalities of methionine and/or homocysteine derivatives.
An Improved CSP Algorithm and Application in Motor Imagery Recognition

An improved common special pattern (CSP) algorithm was proposed to improve classification accuracy of motor imagery electroencephalograph(EEG) in a brain-computer interface (BCI) system. Three channels EEGs were filtered through the time window and band-pass filter to obtain the most obvious features of event-related desynchronization and event-related synchronization. Improved CSP algorithm combined with support vector machine (SVM) as adopted for the classification of motor imagery EEGs. The experiment results show that the improved CSP algorithm can avoid the repetitive eigenvector selection and discriminate the left hand and right hand mental task more accurately than the traditional CSP.
A Clustering Algorithm Solution to the Collaborative Filtering

91 A Clustering Algorithm Solution to the Collaborative Filtering Yongli Yang 1, , Fei Xue 2, , Yongquan Cai 1, c Zhenhu Ning 1, d,* and Haifeng Liu 3, e Faculty of Information Technology, Beijing University of Technology, Beijing 100124, China; School of Information, Beijing Wuzi University, Beijing 101149, China; Science and Technology on Information Systems, Engineering Laboratory, Beijing Institute of Control and Electronic Technology, Beijing 100038, China.
Management of dyslipidemia in patients with metabolic syndrome.

OBJECTIVE To review the management of dyslipidemia in patients with metabolic syndrome. DATA SOURCES Medline search (2000-2002) conducted for English language articles using the search terms metabolic syndrome, impaired fasting glucose, glucose intolerance, and antilipemic agents; selective search for clinical trials of lipid therapy conducted in dialogue databases (1990-2002). In addition, current dyslipidemia treatment guidelines reviewed. STUDY SELECTION By the author. DATA EXTRACTION By the author. DATA SYNTHESIS The metabolic syndrome is increasingly recognized as a strong predictor of patient risk for developing coronary artery disease (CAD). It is associated with an atherogenic dyslipidemia characterized by elevated levels of triglycerides, reduced levels of high-density lipoprotein cholesterol (HDL-C) and a preponderance of small dense low-density lipoprotein (LDL) particles. Controlled clinical trials show similar or greater cardiovascular benefits from lipid-modifying therapies in patient subgroups with diabetes, impaired fasting glucose, and metabolic syndrome, compared with overall study populations. Current guidelines recommend intensified lipid management. Therapeutic lifestyle changes, with emphasis on weight loss, are particularly important for patients with metabolic syndrome. Statins are first-line therapy for all patients whose LDL-C levels are above goal. Combination therapy may often be necessary to control all lipid abnormalities adequately. Both niacin and fibrates provide additional benefits, particularly on triglyceride and HDL-C levels. Recent clinical studies show that these agents, in combination with statins, are safe and effective for the treatment of atherogenic dyslipidemia. CONCLUSION Atherogenic dyslipidemia represents an important modifiable CAD risk factor. Combination therapy with agents that focus on all of the components of the mixed dyslipidemia that often occurs in persons with diabetes and the metabolic syndrome may be expected to reduce cardiovascular morbidity and mortality.
Verdad sobre la no existencia: un problema para la teoría reduccionista de Tim Crane. Nota crítica sobre "The Objects of Thought": Tim Crane, "The Objects of Thought", Oxford University Press, Oxford, 2013, 208 pp.

El objeto de esta nota crítica es comentar algunas de las ideas que aparecen en el libro The Objects of Thought (2013) de Tim Crane y, posteriormente, discutir con más detalle una de ellas, concretamente la propuesta de Crane para explicar la verdad sobre lo que decimos acerca de cosas que no existen —en lo que sigue me referiré a esto como “problema de la no existencia”—. La tarea de explicar estos casos —en los que pensamos o decimos que es verdad que un objeto no existente tiene tal y cual propiedad— ha ocupado un lugar destacado entre los problemas filosóficos desde la antigüedad (cfr. Teeteto 189a). Así que, además de tener presencia histórica en la literatura, este problema sobresale entre las principales cuestiones filosóficas porque supone un obstáculo importante para las posiciones que parten de la concepción tradicional de lo mental y que tratan de dar cuenta de la función y naturaleza de la mente, como es el caso de Crane en la obra que comentamos aquí. 1 En su libro, Crane ofrece una solución reduccionista al problema de la no existencia.2 Su propuesta consiste en explicar la verdad de lo que decimos acerca de algo que no existe apelando a su dependencia de otras verdades sobre
Out, Damned CLIP! Out, I Say!

The major histocompatibility complex (MHC) class II molecule displays peptide fragments of foreign proteins to trigger a defensive reaction from the immune system. Before insertion of the foreign peptides into the class II binding groove, a place-holding peptide CLIP must be removed. This is accomplished by the molecule DM, which is shown to increase the dissociation rate of a small class II-associated Ii peptide (CLIP) from class II (see report by Weber et al., p. 618). Roche explains how DM can tell the difference between the class II-CLIP and foreign peptide-CLIP complexes.
Conditional Use of Sex and Parthenogenesis for Worker and Queen Production in Ants

The near-ubiquity of sexual reproduction in animal species has long been considered a paradox because sexually reproducing individuals transmit only half of their genome to their progeny. Here, we show that the ant Cataglyphis cursor circumvents this cost by using alternative modes of reproduction for the production of reproductive and nonreproductive offspring. New queens are almost exclusively produced by parthenogenesis, whereas workers are produced by normal sexual reproduction. By selectively using sex for somatic growth and parthenogenesis for germline production, C. cursor has taken advantage of the ant caste system to benefit from the advantages of both sexual and asexual reproduction.
Dihydroxy bile salt-induced alterations in NaCl transport across the rabbit colon.

The effects of increasing mucosal or serosal concentrations (1-4 mM) of taurochenodeoxycholate (TCDC) on sodium chloride transport across the isolated, short-circuited rabbit colon were examined. Mucosal TCDC produced dose-related increases in tissue conductance (Gt) and the unidirectional fluxes of Na+ and Cl- and dose-related decreases in net NaCl absorption. At 4 mM mucosal TCDC, Gt was increased fivefold, net sodium flux (JNanet) was reduced 50%, and JClnet was abolished. Serosal TCDC also produced dose-dependent changes in permeability that were quantitatively different. Four millimolar serosal TCDC produced a 2.7-fold increase in Gt, abolished JNanet, and stimulated electrogenic Cl- secretion. TCDC-induced Cl- secretion was stimulated by 10(-5) M serosal TCDC, inhibited by serosal furosemide or ouabain, did not alter theophylline-induced secretion (and vice versa), and occurred in the absence of serosal Ca2+. It is suggested that 1) TCDC inhibition of sodium absorption is indirect (i.e., not simply due to a reduction in the activity of the Na "pump," since Cl- secretion persists during conditions that abolish JNanet) and 2) TCDC induces Cl- secretion by enhancing the activity of basolateral membrane adenylate cyclase.
Anatomic Double-bundle ACL Reconstruction

Rupture of the anterior cruciate ligament (ACL) is one of the most frequent forms of knee trauma. The traditional surgical treatment for ACL rupture is single-bundle reconstruction. However, during the past few years there has been a shift in interest toward double-bundle reconstruction to closely restore the native ACL anatomy. This paper evaluates the basis for double-bundle ACL reconstruction including anatomy, biomechanics and kinematics, describes our surgical technique, and discusses why we prefer anatomic double-bundle ACL reconstruction, as well as its outcome, the choices, and the controversies of double-bundle ACL reconstruction. Pitfalls of traditional ACL surgery are also discussed, the recognition of which is the key to performing anatomic ACL reconstruction.
Use of indigenous technology for the production of high quality cassava flour with similar food qualities as wheat flour.

BACKGROUND The aim of the paper was to compare the food qualities of 2 varieties (SME 1 and 2) of high quality cassava flour (HQCF) produced from indigenous technology and that of some commercially sold wheat/HQCF samples. MATERIAL AND METHODS The pH, proximate, phytochemical, antioxidant, functional properties and starch yield of the flours were carried out using standard techniques. RESULTS The wheat flours had higher bulk densities and lipids than the HQCF samples while the oil absorption capacity of the HQCF (SME 2) was higher than other fl our samples investigated. The antioxidant assays of the flours showed that they contained considerable levels of antioxidants with the HQCF sample from DAT having higher antioxidants than other flour samples studied. The HQCF (SME 1) had significantly higher (P < 0.05) starch content among the flour samples. The bacteria counts of the HQCF samples ranged from 0 to 1.4 × 10(4) cfu/ml while the fungal count ranged from 0 to 2 × 10(-3) with the unbranded wheat fl our having the highest microbial load compared with other flour samples studied. CONCLUSION The use of this indigenous technology produces HQCF with lower lipids, microbial contamination but higher flavour retaining ability, flavonoids and starch contents than wheat flour. The significant positive correlation (R2 = 0.872) between reducing power of the samples and their DPPH antioxidant activity indicate that either could be used to assay for the total antioxidant activity of cassava and wheat flour. The study underscores the need to buy flour from branded companies to reduce the risks of microbial contamination.