Miracle-dz/UniFAR-FTUs huggingface dataset:
DBBRBF- Convalesce optimization for software defect prediction problem using hybrid distribution base balance instance selection and radial basis Function classifier

Software is becoming an indigenous part of human life with the rapid development of software engineering, demands the software to be most reliable. The reliability check can be done by efficient software testing methods using historical software prediction data for development of a quality software system. Machine Learning plays a vital role in optimizing the prediction of defect-prone modules in real life software for its effectiveness. The software defect prediction data has class imbalance problem with a low ratio of defective class to non-defective class, urges an efficient machine learning classification technique which otherwise degrades the performance of the classification. To alleviate this problem, this paper introduces a novel hybrid instance-based classification by combining distribution base balance based instance selection and radial basis function neural network classifier model (DBBRBF) to obtain the best prediction in comparison to the existing research. Class imbalanced data sets of NASA, Promise and Softlab were used for the experimental analysis. The experimental results in terms of Accuracy, F-measure, AUC, Recall, Precision, and Balance show the effectiveness of the proposed approach. Finally, Statistical significance tests are carried out to understand the suitability of the proposed model.
Albertson’s Conjecture on Crossing Numbers

In this paper, we prove the Albertson’s Conjecture which states that “If graph G has chromatic number r, then the crossing number of G is atleast that of the Kr” for 7 ≤ r ≤ 10 using results of Dirac, Gallai and Kostochka Stiebitz and Pach et al.
Improvement of hearing results by bone cement fixation in endoscopic stapedotomy.

OBJECTIVE This study aimed to compare the hearing results of two different stapedotomy techniques used in the clinic at different time points. METHODS An endoscopic surgery group (group 1; n = 37) were compared retrospectively with a microscopic surgery group (group 2; n = 57). A small fenestra and Teflon piston technique were used in all patients. Bone cement was used for fixation between the prosthesis and incus in the endoscopic group only. Bone conduction threshold and air-bone gap were used as the comparison parameters. RESULTS The pre-operative air-bone gap was 31.26 dB in group 1 and 32.51 dB in group 2. The post-operative air-bone gap was 8.93 dB in group 1 and 14.28 dB in group 2. There was a significant difference between the groups in post-operative air-bone gaps. There was no significant difference between the groups in post-operative bone conduction thresholds. CONCLUSION The endoscopic technique using bone cement fixation was better for closing the air-bone gap.
Pest Cockroaches May Overcome Environmental Restriction Due to Anthropization

Abstract Our species have altered their surroundings since its early dispersion on Earth. Unfortunately, thanks to human-modified habitats, several pest organisms such as domiciliary insects have expanded their distributions. Moreover, pest-related microorganisms may also be aided by anthropization. Pest cockroaches are globally distributed and capable of carrying several diseases. We explored if urbanization may buffer environmental conditions allowing pest insects to expand their distribution. Specifically, we suggest that human settlements may generate suitable microhabitats for synanthropic cockroaches, helping them to survive and establish with disregard to overall climatic restrictions.To test this idea we studied the distribution of pest cockroaches spanning the length of Chilean territory. Chile, along its 4270 km length north to south extent, is a country offering a formidable sampling of Earth's climatic diversity accompanied by dense urbanizations. We studied entomological collections and spatially analyzed pest cockroach distribution found in Chile and discovered that synanthropic cockroach populations are consistently concentrated near most urban developed zones of the country and not limited by overall temperature. Furthermore, health-concern pest cockroach species were widely distributed in Chilean territory, found even in its most southern urban centers as well as Easter Island. Therefore, these disease vectors could exist even in isolated and extreme climatic zones as long as urbanization provides the adequate microhabitat. We discuss the need for further research in order to assess if these distributions can be extrapolated to the pathogenic strains these pest insects may be carrying as reported in other regions of the planet.
Comparative assessment of the Euglena gracilis var. saccharophila variant strain as a producer of the β‐1,3‐glucan paramylon under varying light conditions

Euglena gracilis Z and a “sugar loving” variant strain E. gracilis var. saccharophila were investigated as producers of paramylon, a β‐1,3‐glucan polysaccharide with potential medicinal and industrial applications. The strains were grown under diurnal or dark growth conditions on a glucose–yeast extract medium supporting high‐level paramylon production. Both strains produced the highest paramylon yields (7.4–8 g · L−1, respectively) while grown in the dark, but the maximum yield was achieved faster by E. gracilis var. saccharophila (48 h vs. 72 h). The glucose‐to‐paramylon yield coefficient Ypar/glu = 0.46 ± 0.03 in the E. gracilis var. saccharophila cultivation, obtained in this study, is the highest reported to date. Proteomic analysis of the metabolic pathways provided molecular clues for the strain behavior observed during cultivation. For example, overexpression of enzymes in the gluconeogenesis/glycolysis pathways including fructokinase‐1 and chloroplastic fructose‐1,6‐bisphosphatase (FBP) may have contributed to the faster rate of paramylon accumulation in E. gracilis var. saccharophila. Differentially expressed proteins in the early steps of chloroplastogenesis pathway including plastid uroporphyrinogen decarboxylases, photoreceptors, and a highly abundant (68‐fold increase) plastid transketolase may have provided the E. gracilis var. saccharophila strain an advantage in paramylon production during diurnal cultivations. In conclusion, the variant strain E. gracilis var. saccharophila seems to be well suited for producing large amounts of paramylon. This work has also resulted in the identification of molecular targets for future improvement of paramylon production in E. gracilis, including the FBP and phosophofructokinase 1, the latter being a key regulator of glycolysis.
IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells

ABSTRACT MicroRNA let-7 has been reported to be down-regulated in several human cancers and is now characterized as a tumor suppressor. IGF1R is over-expressed in many cancers and IGF1/IGF1R pathway is attractive target for anticancer therapy. However, the crosstalk between let-7 and IGF1/IGF1R are largely unknown. The present study showed IGF1R were significantly over-expressed in colorectal cancer tissues compared with adjacent normal tissues through immunohistochemical analysis. qRT-PCR results showed that let-7a, let-7b and let-7e were down-regulated in colorectal cancer tissues. Bioinformatics analysis revealed that both IGF1 and IGF1R mRNA are potential targets for let-7 miRNA family. Ectopic transfection of let-7e led to a significant reduction in IGF1R at protein level and their downstream Akt inhibition, as well as a reduction in cell proliferation, migration and invasion in colorectal cancer cells, while inhibition of let-7e enhanced the expression of IGF1R. On the other hand, IGF1 stimulation can significantly down-regulate the expression of let-7e in colorectal cancer cells. Taken together, our findings identify a negative feedback regulation between let-7e and IGF1/IGF1R, and suggest that let-7e could be used in IGF1R-targeted therapeutics in anticancer therapy. Abbreviations: IGF1: insulin-like growth factor 1; IGF1R: IGF1 receptor; miRNA: microRNA; CRC: colorectal cancer; EGFR: epidermal growth factor receptor; HRP: horseradish peroxidase; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide; p-Akt: phospho-Akt; PI3K: phosphoinositide 3-kinase; qRT–PCR: quantitative reverse transcription–PCR; IHC: immunohistochemical; siRNA: small interfering RNA; 3′-UTR: 3′-untranslated region
Effect of Textile Waste Water on Vigna unguiculata var . RC-101 ( cow pea ) in a Pot Experiment with Reference of Heavy Metal Bioaccumulation

The plants of Vigna unguiculata var. RC-101 (cow pea) treated with different level of waste water and analyzed for metal accumulation, growth and biochemical parameters at pre, peak and post flowering stages. Findings of the study revealed that chlorophyll content was most severely affected with the increase in metal concentration. Total chlorophyll content showed a reduction of 56.55percent while carbohydrate, protein and nitrogen content showed a reduction of 47.83 percent, 55.31 percent and 55.40 percent respectively. With the increase in wastewater treatment the root and shoot length, root and shoot dry weight were reduced to 45.43 percent, 29.48 percent, 61.97 percent, 53.11 percent respectively. After crop harvesting, the fruit samples of the plants treated with highest concentration of textile waste(50 percent waste water mixed with 50 percent of distilled water) water contained 5.257 mg g -1 d.wt. of Zn, 2.518 mg g -1 d.wt. Cu, 1.276 mg g -1 d.wt. Ni, 1.895 mg g -1 d.wt. Cd, 4.893 mg -1 d.wt. Cr , 1.897 mg g -1 d.wt. Pb and 1.854 mg g -1 d.wt. Co.
Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective

The self-assembly of proteins and peptides into amyloids is a key feature of an increasing number of diseases. Amyloid fibrils display a unique surface reactivity endowing the sequestration of molecules such as MicroRNAs, which can be the active moiety of the toxic action. To test this hypothesis we studied the recognition between a model RNA and two different steric zipper spines using molecular dynamics simulations. We found that the interaction occurs and displays peptide-sequence dependence. Interestingly, interactions with polar zipper surfaces such as the formed by SNQNNF are more stable and favor the formation of β-barrel like complexes resembling the structures of toxic oligomers. These sequence-structure-recognition relationships of the two different assemblies may be exploited for the design of compounds targeting the fibers or competing with RNA-amyloid attachment
A Secure Approach for Deduplication using Hybrid Cloud

: Data deduplication is one of important data compression techniques for eliminating duplicate copies of repeating data, and has been widely used in cloud storage to reduce the amount of storage space and save bandwidth. To protect the conﬁdentiality of sensitive data while supporting deduplication, the convergent encryption technique has been proposed to encrypt the data before outsourcing. To better protect data security, this study makes the ﬁrst attempt to formally address the problem of authorized data deduplication. Different from traditional deduplication systems, the differential privileges of users are further considered in duplicate check besides the data itself, also several new deduplication constructions supporting authorized duplicate check in hybrid cloud architecture. Security analysis demonstrates that our scheme is secure in terms of the deﬁnition speciﬁed in the proposed security model and shows that the proposed authorized duplicate check scheme incurs minimal overhead compared to normal operations.
Stochastic modelling of urban structure

The building of mathematical and computer models of cities has a long history. The core elements are models of flows (spatial interaction) and the dynamics of structural evolution. In this article, we develop a stochastic model of urban structure to formally account for uncertainty arising from less predictable events. Standard practice has been to calibrate the spatial interaction models independently and to explore the dynamics through simulation. We present two significant results that will be transformative for both elements. First, we represent the structural variables through a single potential function and develop stochastic differential equations to model the evolution. Second, we show that the parameters of the spatial interaction model can be estimated from the structure alone, independently of flow data, using the Bayesian inferential framework. The posterior distribution is doubly intractable and poses significant computational challenges that we overcome using Markov chain Monte Carlo methods. We demonstrate our methodology with a case study on the London, UK, retail system.
Differences in Therapeutic Responses and Factors Affecting Post-Stroke Depression at a Later Stage According to Baseline Depression

Background and Purpose The pathophysiology of post-stroke depression (PSD) is complex and may differ according to an individual’s mood immediately after stroke. Here, we compared the therapeutic response and clinical characteristics of PSD at a later stage between patients with and without depression immediately after stroke. Methods This study involved a post hoc analysis of data from EMOTION (ClinicalTrials.gov NCT01278498), a placebo-controlled, double-blind trial that examined the efficacy of escitalopram (10 mg/day) on PSD and other emotional disturbances among 478 patients with acute stroke. Participants were classified into the Baseline-Blue (patients with baseline depression at the time of randomization, defined per the Montgomery-Asberg Depression Rating Scale [MADRS] ≥8) or the Baseline-Pink groups (patients without baseline depression). We compared the efficacy of escitalopram and predictors of 3-month PSD (MADRS ≥8) between these groups. Results There were 203 Baseline-Pink and 275 Baseline-Blue patients. The efficacy of escitalopram in reducing PSD risk was more pronounced in the Baseline-Pink than in the Baseline-Blue group (p for interaction=0.058). Several risk factors differentially affected PSD development based on the presence of baseline depression (p for interaction <0.10). Cognitive dysfunction was an independent predictor of PSD in the Baseline-Blue, but not in the Baseline-Pink group, whereas the non-use of escitalopram and being female were more strongly associated with PSD in the Baseline-Pink group. Conclusions Responses to escitalopram and predictors of PSD 3 months following stroke differed based on the presence of baseline depression. Our data suggest that PSD pathophysiology is heterogeneous; therefore, different therapeutic strategies may be needed to prevent PSD emergence following stroke.
Delayed celiac disease diagnosis predisposes to reduced quality of life and incremental use of health care services and medicines: A prospective nationwide study

Background Celiac disease is challenging to recognize, predisposing to long diagnostic delay. Currently, associated factors and significance of the delay remain obscure. Objective The objective of this article is to investigate associated sociodemographic risk factors and health consequences of diagnostic delay in celiac disease. Methods Altogether 611 patients were surveyed at diagnosis and after one year on a gluten-free diet regarding sociodemographic variables, well-being and use of medicines and health care services. Quality of life was measured by a validated Psychological General Well-Being (PGWB) questionnaire. The results were compared between patients with and without delayed (≥3 years) diagnosis. Results A total of 332 (54%) individuals reported a delay of ≥3 years. Associated with the delay were being a student or homemaker, but not gender, marital or occupational status, site of diagnosis or place of residence. Patients with the delay also had decreased self-perceived health and poorer PGWB scores compared to those without delay; in anxiety and general health this was seen even on a gluten-free diet. Days of sickness and doctor visits as well as use of drugs for dyspepsia and antidepressants were increased in the delay group both before and after diagnosis. Conclusion A delay in celiac disease diagnosis predisposes to reduced well-being and incremental use of medicines and health care services, both before diagnosis and one year after diagnosis.
Chemoenzymatic Deracemization of Chiral Sulfoxides.

The highly enantioselective enzyme methionine sulfoxide reductase A was combined with an oxaziridine-type oxidant in a biphasic setup for the deracemization of chiral sulfoxides. Remarkably, high ee values were observed with a wide range of substrates, thus providing a practical route for the synthesis of enantiomerically pure sulfoxides.
Graph Theory Towards New Graphical Passwords In Information Networks

Graphical passwords (GPWs) have been studied over 20 years. We are motivated from QR codes that can be considered GPWs, are successfully applied in today's world. However, one need such GPWs that can be use conveniently and have higher level security in information networks. We aim to GPWs for mobile devices with touch screen. No more researching papers of GPWs by means of techniques of graph theory that are already used in a wide range of scientific areas, especially, dynamic networks. Our investigation is devoted to designing new type of graphical passwords by methods of graph theory, such as various topological structures and colorings (labellings). We develop the idea of "topological structure plus number theory" in maximal planar graphs, and provide new techniques for designing new type of GPWs, and furthermore we do theoretical analysis on these new type of GPWs.
Function of PM 2 . 5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases ( Review )

Previous research has identified that air pollution is associated with various respiratory diseases, but few studies have investigated the function served by particulate matter 2.5 (PM2.5) in these diseases. PM2.5 is known to cause epigenetic and microenvironmental alterations in lung cancer, including tumor‐associated signaling pathway activation mediated by microRNA dysregulation, DNA methylation, and increased levels of cytokines and inflammatory cells. Autophagy and apoptosis of tumor cells may also be detected in lung cancer associated with PM2.5 exposure. A number of mechanisms are involved in triggering and aggravating asthma and COPD, including PM2.5‐induced cytokine release and oxidative stress. The present review is an overview of the underlying molecular mechanisms of PM2.5‐induced pathogenesis in lung cancer and chronic airway inflammatory diseases.
Species Diversity of Oak Stands and Its Significance for Drought Resistance

Drought periods have an adverse impact on the condition of oak stands. Research on different types of ecosystems has confirmed a correlation between plant species diversity and the adverse effects of droughts. The purpose of this study was to investigate the changes that occurred in an oak stand (Krotoszyn Plateau, Poland) under the impact of the summer drought in 2015. We used a method based on remote sensing indices from satellite images in order to detect changes in the vegetation in 2014 and 2015. A positive difference was interpreted as an improvement, whereas a negative one was treated as a deterioration of the stand condition. The Shannon-Wiener species diversity was estimated using an iterative principal component analysis (PCA) algorithm based on aerial images. We observed a relationship between the species indices of the individual forest divisions and their response to drought. The highest correlation between the index differences and the Shannon-Wiener indices was found for the Green Normalized Difference Vegetation Index (GNDVI) index (+0.74). In addition, correlations were observed between the mean index difference and the percentage shares in the forest divisions of species such as Pinus sylvestris L. (P. sylvestris) (+0.67 ± 0.08) and Quercus robur L. (Q. robur) (−0.65 ± 0.10). Our results lead us to infer that forest management based on highly diverse habitats is more suitable to meet the challenges in the context of global climatic changes, characterized by increasingly frequent droughts.
Choline-related metabolites influenced by feeding patterns in preterm and term infants

Abstract Objective : This study was performed to examine the choline status on term and preterm infants using urinary metabolome analysis. Material and methods: Samples were collected from 19 term and 20 preterm infants between 15 days and 1 month, respectively. The infants were separated into four groups: the term-breast group (TB, n = 13), the term-formula group (TF, n = 6), the preterm-breast (PB, n = 11), and the preterm-mixed group (PM, n = 9). Urinary metabolome analysis was performed using capillary electrophoresis–time-of-flight mass spectrometry (CE–TOF/MS). We also performed metabolome analysis of the infant formulas. Results: Urinary excretion of choline metabolites (choline, N,N-dimethylglycine, sarcosine, and betaine) was significantly higher in TB than TF infants (p < .05). Choline, betaine, and sarcosine excretion was not significantly different between the PB and TB infants. Choline and N,N-dimethylglycine excretion was significantly higher in PM than PB infants. Choline metabolites excretion was also significantly higher in PM than TF infants. Choline and betaine levels were significantly higher in the preterm than term formula used in this study. Conclusions: The type of feeding in early infancy affects choline metabolism. Metabolome analysis is useful for assessing choline metabolism to modify the contents of infant formulas also in preterm infants.
EPIDEMIOLOGY A N D MECHANISMS RELATING DIET TO RISK OF COLORECTAL CANCER

I N T E R V E N T I O N S T U D I E S . DIET A N D CHEMICALLY I N D U C E D CARCINOGENESIS . N O N S T A R C H P O L Y S A C C H A R I D E S , S T A R C H . FAT, E N E R G Y . n-3 A N D n-6 F A T T Y A C I D S . PROTEIN A N D MEAT . POTENTIAL M E C H A N I S M S . THE C O L O N I C F L O R A A N D FERMENTATION . Carbohydrate. Dilution, stool weight and transit time . Butyrate. Fat, bile acids, p H . Diacylglycerol . Calcium. 198 20 1 203