Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting the Ovarian Response in ART Cycles Using Rateof Increase in Serum Estradiol on Day Six of ControlledOvarian Hyperstimulation

Objective: Although, earlier studies have evaluated the significance of various estradiol patterns during controlled ovarian hyperstimulation (COH), their prognostic significance remains unclear. The objective of this study is to investigate the rate of increase in estradiol (ROI-E2) during COH and evaluate it as a predictor of ovarian response. Materials and Methods: In this retrospective study, 130 patients undergoing COH for IVF/ICSI cycles were reviewed. The E2 level during COH was evaluated on day 1, 5, 6, 7 & 8 and the ROI-E2 was determined. Age, basal FSH, number of mature follicles, number and maturity of oocytes, and incidence of ovarian hyperstimulation syndrome (OHSS) were recorded and their relationship with ROI-E2 was determined. Results: Patients with elevated basal FSH have shown poor ROI-E2 on day six and a significant negative correlation was observed. Similarly, patients with advanced age group demonstrated poor ROI-E2 on day six. The average ROI-E2 on day six was significantly higher in patients who developed OHSS than non-OHSS group. The number of follicles, oocytes and maturity of the oocytes were maximum among the patients with higher ROI-E2 on day six. Discussion: In a COH cycle, there is significant predictive association between ROI-E2 on day six and good ovarian response and hyper-response.
The effects of XPM-induced fast polarization-state fluctuations on PMD compensated WDM systems

We show numerically and experimentally the system degradation caused by cross-phase modulation-induced fast polarization fluctuations in wavelength-division-multiplexing systems that use polarization-mode dispersion compensation. A simple pump-probe model is used to investigate this effect and a technique is proposed to mitigate this problem. For a 10-Gb/s system with a 40-ps differential group delay compensator, the significant improvement is achieved over standard systems by using this technology.
Inflammatory metastatic carcinoma of the breast.

Inflammatory metastatic carcinoma of the breast is an uncommon but well-known entity. Since it clinically can stimulate an inflammatory or infectious process, eg, erysipelas or cellulitis, it is frequently misdiagnosed. 1 We report a rare case of carcinoma of the breast in which the initial-appearing sign for a short period was an inflammatory site of metastatic carcinoma on the left forearm. Report of a Case A 62-year-old woman was first seen in January 1979 at the Dermatology Clinic of the University of Texas Medical Branch, Galveston, with a four-month history of edema and pruritus in an inflammatory plaque of the left forearm. A month after onset, she noticed a small nodule on the left breast that grew rapidly and eventually ulcerated. Physical examination showed a well-nourished patient with normal vital signs. A 2 × 2-cm ulcer in the lateral upper quadrant of the left breast and a 2 × 2-mm
Ethyl Pyruvate Attenuates Spinal Cord Ischemic Injury with a Wide Therapeutic Window through Inhibiting High-mobility Group Box 1 Release in Rabbits

Background:Ethyl pyruvate (EP) has been reported to offer a protective effect against ischemic injury through its antiinflammatory action. The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from ischemic cells. This study was designed to investigate the neuroprotective effect of EP against spinal cord ischemic injury and the potential role of HMGB1 in this process. Methods:EP was administered at various time points before or after 20 min of spinal cord ischemia in male New Zealand rabbits. All animals were sacrificed at 72 h after reperfusion with modified Tarlov criteria, and the spinal cord segment (L4) was harvested for histopathological examination and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling staining. The HMGB1 levels in serum and spinal cord tissue were analyzed by enzyme-linked immunosorbent assay. Results:The treatment of EP at 30 min before ischemia or at 6 h after reperfusion significantly improved the hind-limb motor function scores and increased the numbers of normal motor neurons, which was accompanied with reduction of the number of apoptotic neurons and levels of HMGB1 in serum and spinal cord tissue. The HMGB1 contents of spinal cord tissue correlated well with the numbers of apoptotic motor neurons in the anterior spinal cord at 72 h after reperfusion. Conclusion:These results suggest that EP affords a strong protection against the transient spinal cord ischemic injury with a wide therapeutic window through inhibition of HMGB1 release.
Genomic and Proteomic Characterization of the Broad-Host-Range Salmonella Phage PVP-SE1: Creation of a New Phage Genus

ABSTRACT (Bacterio)phage PVP-SE1, isolated from a German wastewater plant, presents a high potential value as a biocontrol agent and as a diagnostic tool, even compared to the well-studied typing phage Felix 01, due to its broad lytic spectrum against different Salmonella strains. Sequence analysis of its genome (145,964 bp) shows it to be terminally redundant and circularly permuted. Its G+C content, 45.6 mol%, is lower than that of its hosts (50 to 54 mol%). We found a total of 244 open reading frames (ORFs), representing 91.6% of the coding capacity of the genome. Approximately 46% of encoded proteins are unique to this phage, and 22.1% of the proteins could be functionally assigned. This myovirus encodes a large number of tRNAs (n=24), reflecting its lytic capacity and evolution through different hosts. Tandem mass spectrometric analysis using electron spray ionization revealed 25 structural proteins as part of the mature phage particle. The genome sequence was found to share homology with 140 proteins of the Escherichia coli bacteriophage rV5. Both phages are unrelated to any other known virus, which suggests that an “rV5-like virus” genus should be created within the Myoviridae to contain these two phages.
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

Objective: In a multicentre study to explore the effects of licofelone as a disease-modifying osteoarthritis drug in comparison with naproxen in patients with knee osteoarthritis (OA), using MRI and x-ray examination. Methods: Patients with knee OA (n = 355) were randomised to receive either licofelone (200 mg twice a day) or naproxen (500 mg twice a day). MRI and x-ray examinations were performed at baseline, 6 months (MRI only), 12 and 24 months. MRI was used to assess quantitatively changes in cartilage volume, and x-ray examinations (Lyon–Schuss) to measure changes in the mean and minimum joint space width (JSW) in the medial compartment. Questionnaires probing symptoms were completed. Data were presented as intention to treat (ITT) and according to protocol (ATP). Results: Cartilage volume loss in the global joint and medial and lateral compartments was significantly less in the licofelone than in the naproxen group for ITT at 12 and 24 months and for ATP at all times except in the medial compartment. Patients with medial meniscal extrusion had a greater loss of cartilage volume. In these patients, licofelone markedly reduced the cartilage loss for both ITT and ATP at 12 and 24 months. Although licofelone showed less reduction in the JSW than naproxen, this did not reach significance. All clinical variables were improved at 24 months (p<0.001) for both groups, with a good safety profile. Conclusion: Licofelone and naproxen were equally effective in reducing OA symptoms; however, licofelone significantly reduced cartilage volume loss over time, thus having a protective effect in patients with knee OA. This study proves the superiority of quantitative MRI over x-ray examinations in a multicentre clinical trial.
Placenta Percreta Causing Rupture of Uterus in Second Trimester of Pregnancy in Non Scarred Uterus with an Unusual Presentation: A Case Report and Review of Literature

Placenta percreta causing second trimester, spontaneous uterine rupture in non high risk women is less frequent and fewer cases have been reported in the literature. We report a case of uterine rupture in second trimester of pregnancy due to placenta percreta with non specific symptoms in otherwise uncomplicated pregnancy without any high risk factors. This case report describes the case of young woman presenting second gravid with 21 weeks pregnancy with complaints of whole abdomen pain and dysuria. Ultrasonography shows single intrauterine dead fetus; placenta was fundoposterior in upper segment, a hypoechoic area seen below the placenta suggestive of abruption placentae or placenta accreta. Suddenly patient deteriorated in two hours of hospital stay, frank hemoperitoneum detected, emergency laparotomy done, per operatively whole fundal area of uterus became papery thin and cystic on touch, a small rent seen on fundal surface of uterus. The placenta was densely adhered to the fundoposterior aspect of the uterus. Patient had emergency subtotal hysterectomy. This case highlights that placenta percreta is a rare but serious complication of pregnancy which may present in early pregnancy without any associated high risk factors for placenta percreta with unusual symptoms.
Phospholipase A2 and protein kinase C contribute to myofilament sensitization to 5‐HT in the rabbit mesenteric artery.

1. Calcium (Ca2+, 0.1‐100 microM) stimulated concentration‐dependent contractions in small strips from the rabbit mesenteric artery in which the smooth muscle cells had been permeabilized with Staphylococcus aureus alpha‐toxin. 2. 5‐Hydroxytryptamine (5‐HT) and phenylephrine, each in the presence of 10 microM guanosine 5'‐triphosphate (GTP), concentration‐dependently stimulated additional contractions in strips sub‐maximally contracted by the presence of a buffered concentration of calcium (0.3 microM). All the additional contraction was abolished with the selective inhibitor of protein kinase C, Ro 31‐8220 (10 microM). 3. Quinacrine (10‐50 microM), an inhibitor of phospholipase A2, selectively inhibited the sensitization to 5‐HT, but did not alter the sensitization to either phenylephrine or GTP. 4. Myofilament sensitization to calcium was mimicked by exogenous arachidonic acid (300 microM, in the presence of indomethacin, miconazole and BW755c) and the stable analogue of arachidonic acid, 5,8,11,14‐eicosatetrayonic acid (ETYA, 100 microM), and in both cases did not require the additional presence of GTP. Ro 31‐8220, but not quinacrine, reduced the sensitization to arachidonic acid by around 30%. 5. These results indicate that G protein‐linked myofilament sensitization to calcium in the mesenteric artery that follows the activation of 5‐HT receptors, but not alpha 1‐receptors, involves phospholipase A2. The sensitization stimulated by each of these different receptors, and a component of the response to arachidonic acid, also appears to involve the activation of protein kinase C.
Prediction Equations Underestimate Resting Energy Expenditure in Patients With End-Stage Cystic Fibrosis

Background: Resting energy expenditure (REE) is increased in patients with cystic fibrosis (CF) with end-stage lung disease due to chronic inflammation and pulmonary infections. After lung transplantation (LTx), energy expenditure is expected to be lower because inflammation will decrease. We assessed the agreement between measured and predicted REE in pre-LTx CF and post-LTx patients with CF and differences in REE in pre-LTx CF and post-LTx patients with CF in a cross-sectional study. Methods: Included were 12 pre-LTx patients with CF (9 women; median age 31.6 years; interquartile range [IQR], 23.3–40.0) and 12 patients with CF within 2 years after LTx (6 women; median age 33.5 years; IQR, 22.3–40.3). REE was measured in a fasted state using indirect calorimetry. Values were compared with predicted REE calculated by formulas of Harris-Benedict (1919 and 1984), Schofield, and the World Health Organization (1985). A calculated REE between 90% and 110% of REE measured was considered adequate. Results: Prediction equations underestimate REE in at least 75% of pre-LTx and 33% of post-LTx patients with CF. Mean (SD) REE measured by indirect calorimetry was 1735 (251) kcal pre-LTx and 1650 (235) kcal post-LTx (P = .40). REE expressed per kilogram of fat-free mass (FFM) was 40.5 kcal/kg in pre-LTx patients with CF, which was higher than the 34.3 kcal/kg in post-LTx patients with CF (P = .01). Conclusions: Prediction equations underestimate REE in patients with end-stage CF. REE per kg of FFM is lower post-LTx than pre-LTx in patients with CF. Measurement of REE is recommended for patients with CF, especially pre-LTx, to optimize energy requirements for improving nutrition status.
Information Goods and Vertical Differentiation

Second-degree price discrimination, that is, vertical differentiation, is widely practiced by firms selling physical goods to consumers with heterogeneous valuations. This strategy leads to market segmentation and has been shown to be optimal by many researchers. On the other hand, researchers have also demonstrated, under certain restrictive conditions, that vertical differentiation may not be optimal for information goods. We analyze vertical differentiation for a monopolist, continuing the practice of modeling consumer valuation as a linear function of product quality and consumer type but generalizing assumptions about marginal costs and consumer distributions. We show that the firm's optimal product line depends on the benefit-to-cost ratio of qualities in the choice vector. We find that a vertical differentiation strategy is not optimal when the highest quality product has the best benefitto-cost ratio. Many information goods satisfy this property.
A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment

Article abstract-Given the relationship between the presence of ApoE epsilon 4 and Alzheimer's disease (AD), we studied whether knowledge of epsilon 4 status would predict which memory-impaired patients would develop AD over time. One hundred seven patients who presented with memory impairment but not dementia were referred to the study by their family physicians. These patients were followed prospectively over a 2-year period. Twenty-nine patients developed AD, while 78 did not develop dementia. We found that ApoE genotype was a reliable prognostic indicator of who developed AD in this group only when memory test performance was included in the predictive model. These findings indicate the limitations of ApoE genotyping in isolation as a prognostic indicator of AD. Because this study included prospectively selected patients who were followed longitudinally, our findings are likely to have more relevance in the clinical setting than those obtained from currently available retrospective studies. NEUROLOGY 1996;46: 149-154
Essay on Rehabilitation of Patients Living with HIV/AIDS

This essay was based on the patient that was admitted to Gondar University referral Hospital in pediatrics main ward with a medical diagnosis of stage III RVI. The main aim of this essay was to explain the rehabilitation care for patients living with HIV/AIDS. AIDS is a chronic infectious disease caused by human immunodeficiency Virus. HIV has distinct characteristics of long period of asymptomatic presentation and finally end up with AIDS manifestation and leads to death. Now a day HIV is considered as a chronic disease due to the introduction of HAART. The HAART intervention helps to long time survivors of the patient and leads to age related CVD and other chronic disease that needs a lifelong rehabilitation care. In the context of HIV, rehabilitation is a continuous process of supportive care that includes both preventive as well treatments. Rehabilitation care covers impairments of physical activity, decrease from social involvement and cognitive impairments. Nursing rehabilitation care for patients living with HIV/AIDS includes self-management education, exercise, nutrition, psychosocial and family support. Patient XY was risk of multiple factors that need rehabilitation care. Among this psychosocial problem, is the prominent one so, nursing profession has indispensable role in this aspect.
Initial work experiences of veterinarians who graduated from Australian universities in 2005.

OBJECTIVE To describe the location, type, support from and effects of their first position for the veterinary graduates of 2005, and to make comparisons with graduates of 1950-2000. PROCEDURE Questionnaires were sent to veterinarians who had graduated from an Australian university in 2005, and data were analysed with SAS System 8 for Windows. RESULTS One-sixth of the graduates left for overseas, and 55% (Murdoch) to 85% (Melbourne) of the remainder found their first veterinary position in the state where they were trained. More were in small animal (48%) and less in mixed practice (48%) than in previous decades, and they spent more time (79%) with dogs and cats, and less with horses (9%), cattle (8%) and other production animals (1%). The median income of males working full-time was $43,000 and $39,000 for equivalent females. Most were satisfied with the help and support received from their boss and workplace; approximately 20% felt that support was inadequate, and many felt overworked and underpaid. The graduates with inadequate support were more likely to suffer stress and were less likely to have enjoyed their first year or to agree that they would become a veterinarian again. The levels of perceived support, and of stress, were similar to those reported by graduates of 2000, though more favourable than in the previous 2 decades. CONCLUSIONS Graduates of 2005 were less likely than their predecessors to start in mixed practice or to work with cattle and horses. Most felt poorly paid, but most, though not all, felt well supported in their first position.
Clustering and Switching Strategies During Verbal Fluency Performance Differentiate Alzheimer's Disease and Healthy Aging

Abstract Clustering and switching strategies during phonemic and semantic verbal fluency tasks as defined by Troyer et al. (1997), Abwender et al. (2001), and Lanting et al. (2009) were compared using archival data to determine which scoring procedures best differentiate healthy older adults (n = 26) from individuals with early-stage Alzheimer's disease (AD, n = 26). Total word production showed the largest group difference, especially for semantic fluency. The AD group produced fewer switches when compared to the healthy control group, whereas the groups did not differ in cluster size. The AD group also accessed fewer novel semantic subcategories, presumably due to reduced access to semantic memory storage rather than lower processing speed. Clustering and switching scores on the phonemic task did not add information above total words produced, consistent with previous research indicating these variables are most informative in relation to semantic fluency. (JINS, 2011, 17, 1153–1157)
The effect of posture on gastroesophageal reflux event frequency and composition during fasting.

OBJECTIVE To examine the influence of three postures (upright and left and right recumbent) on gastroesophageal reflux event (RE) frequency and composition and a possible mechanism for the observations. METHODS A) Forty fasting patients with (E+, n = 20) and without (E-, n =20) esophagitis were studied. Simultaneous manometry and pH monitoring were conducted in the left and right recumbent (10 min each) as well as the upright posture (20 min). RE were classified by the pH probe and/or the manometry catheter as acid or gas RE. B) In 23 patients referred for UGI series, radiographs were taken in the left and right recumbent and upright postures after barium and Fizzies. RESULTS A) Upright RE were similar in frequency in E+ and E- patients (2.6 +/- 0.5 vs 3.05 +/- 0.6). However, E+ patients had more recumbent RE (16.3 +/- 3 vs 0.65 +/- 0.2, p = 0.0001) than E- patients; moreover, the left recumbent posture had more recumbent RE than the right (10.9 +/- 2 vs 5.3 +/- 1, p < 0.02). Moving from recumbent to the upright posture had an opposite effect on RE in the two groups; RE decreased sixfold in E+ patients (16.3 +/- 3 vs 2.6 +/- 0.5, p = 0.0001) but increased fourfold in E- patients (0.65 +/- 0.2 vs 3.05 +/- 0.6, p = 0.0001). In examining RE composition in the E+ patients, RE were twofold more likely to be gas in the left recumbent posture (7.6 +/- 2 vs 3.3 +/- 1, p < 0.1); in direct contrast, RE were eightfold more likely to be acid in the right recumbent posture (4.7 +/- 1 vs 0.6 +/- 0.5, p = 0.0001). As expected from this observation, acid exposure was greater in the right than left posture (52 +/- 8 vs 15 +/- 6%, p < 0.0001). Although RE were too infrequent in E- patients to reach statistical significance, the effect of posture on the composition of the few RE that did occur mirrored that of the E+ patients. B) In 17/23 (74%) radiographs in the right recumbent posture, the EG junction was submerged in a barium pool below the air-barium interface in the stomach. In contrast, this occurred in 0/23 patients in the left recumbent and 1/23 patients in the upright postures because the EG junction was in the air above the barium pool. CONCLUSION Posture has an influence on RE frequency and composition while fasting, and the latter is likely due to whether the EG junction is submerged below liquid gastric contents or in the air above the liquid gastric contents.
Comparative Assessment of the Different American College of Rheumatology/European League Against Rheumatism Remission Definitions for Rheumatoid Arthritis for Their Use as Clinical Trial End Points

The American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) have defined remission using Boolean‐ or index‐based criteria (i.e., a Simplified Disease Activity Index [SDAI] score of ≤3.3). We undertook this study to compare definitions of remission to inform choice of end points for future rheumatoid arthritis (RA) clinical trials, and we also included in our comparison the remission criterion of a score of ≤2.8 on the Clinical Disease Activity Index (CDAI).