Miracle-dz/UniFAR-FTUs huggingface dataset:
Virological and Biochemical Relapse after Discontinuation of Lamivudine Monotherapy for Chronic Hepatitis B in Japan: Comparison with Breakthrough Hepatitis during Long-Term Treatment

Objective: Comparison of virological and biochemical relapse in patients with chronic hepatitis B, based on continuation or discontinuation of lamivudine monotherapy. Methods: In Japanese genotype C-dominant hepatitis B patients, 25 patients who stopped treatment at normal levels of alanine transferase (ALT) were retrospectively compared with 75 patients who continued treatment. Both groups were matched for age, sex, and observation period after start of treatment. We investigated the relapse rates, and evaluated predictive factors for relapse and efficacy of retreatment of the discontinuous group. Results: Virological and biochemical relapse occurred significantly earlier in the discontinuous than continuous group, and the peak levels and ratios of peak to pretreatment levels of serum bilirubin and ALT after relapse were not significantly different between the two groups. Multivariate analysis identified three independent factors at discontinuation of treatment associated with early biochemical relapse: HBeAg positivity, presence of liver cirrhosis, detection of basic core promoter mutant. Normalization of ALT levels with retreatment occurred in 62.5% of patients, but 2 HBeAg-positive patients retreated after the emergence of YMDD motif mutant developed severe relapse with hyperbilirubinemia. Conclusion: Our results in Japanese patients with genotype C-dominant hepatitis B suggest that discontinuation of lamivudine monotherapy, and retreatment after the emergence of YMDD mutant should be given attention.
PENGARUH KARAKTERISTIK PERUSAHAAN TERHADAP PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY

This research is conducted on manufacturing companies in Indonesia. This research is meant to examine the influence of the characteristics of the company to the disclosure of corporate social responsibility. The result of this research shows that the firm size does not have any influence to the disclosure of corporate social responsibility, leverage does not have any influence to the disclosure of corporate social responsibility, profitability does not have any influence to the disclosure of corporate social responsibility, industrial type (profile) does not have any influence to the disclosure of corporate social responsibility, and management ownership does not have any influence to the disclosure of corporate social responsibility. Meanwhile the size of the board of commissioner has an influence to the disclosure of corporate social responsibility. Keywords: Corporate Social Responsibility, characteristics of the company, the Size of the Board of Commissioner, Management Ownership.
Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease

Chronic hepatitis B has highly a dynamic course with significant fluctuations of HBV-DNA and ALT impeding assessment of disease activity. New biomarkers of inflammatory versus noninflammatory stages of HBV infection are urgently needed. Cytokeratin 18 epitope M30 (M30 CK-18) is a sensitive marker of cell death. We aimed to investigate an association between serum M30 CK-18 and histological activity and phase of HBV infection. 150 Caucasian patients with HBV-infection were included in the study. Serum M30 CK-18 levels reflected phase of disease, being significantly higher in both HBeAg(+) and HBeAg(−) hepatitis B in comparison to HBsAg(+) carrier groups. The highest serum M30 CK-18 levels were observed in subjects with the most advanced stages of HBV. Moreover, its serum concentrations correlated with both inflammatory activity and fibrosis advancement (ANOVA P < 0.001). Importantly, serum M30 CK-18 levels were able to discriminate patients with mild versus moderate-advanced fibrosis (AUC: 0.86) and mild versus active liver inflammation (AUC: 0.79). M30 CK-18 serum concentration has good sensitivity and specificity in discriminating mild versus moderate/severe fibrosis and inflammation even in patients with normal ALT activity. This study suggests M30 CK-18 as a potential noninvasive marker of disease activity and also a marker of phase of persistent HBV infection.
Entrepreneurial Families : From a Family Enterprise to an Entrepreneurial Family

How do family firms succeed from generation to generation? While this is likely the most important question for the members of a family business, little is known about the central success factors in creating value across the generations. For this reason, our study aims to explore the secrets of family firms with a long, successful track record and to expand the current state of knowledge. In so doing, we want to look not only at «the family firm» but also broaden our scope to the entire entrepreneurial family behind the company. This is our contribution to a greater understanding of transgenerational value creation in entrepreneurial families, which we hope will in turn benefit a range of stakeholders.
ANALYZING THE EFFECT OF BRAND PERSONALITY AND BRAND EXPERIENCE ON CUSTOMER LOYALTY (A STUDY OF SAMSUNG GALAXY SMARTPHONE)

A bstract : Marketing in its course of development is in a phase in which the organizations are no more only thinking of finding new customers, and nowadays one of the most important goals of marketing is demand management through pushing customers up the loyalty ladder. Customer loyalty is considered to be among the most important and key factors for business success. The goal of the company is to create sustainability and profitability relations with their customers through offered their superior brandto achieve the competitive advantage. This research aims to analyze the brand personality and brand experience of Samsung Galaxy Smartphone on customer loyalty which is concern on 80 respondents who are the consumers. The type of analysis is using Multiple Regression Analysis. The result shows that brand personality and brand experience influence customer loyalty simultaneously. The most significant effects oncustomer loyalty are brand experience. Keywords: Brand Personality, Brand Experience, Customer Loyalty
The Unusual Localization of Right Hepatic Artery Multiple Anatomic Variants in Celiac Axis

The extrahepatic vascular and biliary anatomy of Calot’s triangle is well known to be highly variable and this provides a surgical challenge. The liver has a dual blood supply consisting of the portal vein and the hepatic artery. The hepatic artery which delivers 25% of the blood supply, arises from the celiac trunk. The celiac trunk gives off the left gastric, splenic and common hepatic arteries. The common hepatic artery then divides into gastroduodenal artery and hepatic artery proper which diverts in right and left hepatic arteries. The systic artery usually originates from the right hepatic artery. The “classic” arterial anatomy is present in approximately 75% of cases. The remaining 25% of the cases have many anatomical variants. Here in we present a patient with multiple anatomic variants in celiac trunk which were determined incidentally during laparoscopic cholecystectomy. Being aware of the arterial variations in the liver is really important in surgical procedures in order to avoid bleeding and ischemia.
ORAL POEMS IN THE CONTEXT OF CUSTOMS AND RITUALS

This text proceeds from the basic assumption that the oral literary forms which are born and endure within customs should not be observed independently from the particular custom to which they belong. Wi thout analysis of the custom as a whole and identification of the defined place and role of the text within it, it is impossible fully to comprehend either the sense of the text, or its structure, symbolics, composition or other poetic characteristics. At the same time, oral literary forms often explain the meaning of the individual sequences and details of a ritual.
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

Autism spectrum conditions (ASCs) are heritable conditions characterized by impaired reciprocal social interactions, deficits in language acquisition, and repetitive and restricted behaviors and interests. In addition to more complex genetic susceptibilities, even mutation of a single gene can lead to ASC. Several such monogenic heritable ASC forms are caused by loss-of-function mutations in genes encoding regulators of synapse function in neurons, including NLGN4. We report that mice with a loss-of-function mutation in the murine NLGN4 ortholog Nlgn4, which encodes the synaptic cell adhesion protein Neuroligin-4, exhibit highly selective deficits in reciprocal social interactions and communication that are reminiscent of ASCs in humans. Our findings indicate that a protein network that regulates the maturation and function of synapses in the brain is at the core of a major ASC susceptibility pathway, and establish Neuroligin-4-deficient mice as genetic models for the exploration of the complex neurobiological disorders in ASCs.
Control Strategies for Battery Energy Storage for Wind Farm Dispatching

Integrating a battery energy storage system (BESS) with a large wind farm can smooth out the intermittent power from the wind farm. This paper focuses on development of a control strategy for optimal use of the BESS for this purpose. The paper considers a conventional feedback-based control scheme with revisions to incorporate the operating constraints of the BESS, such as state of charge limits, charge/discharge rate, and lifetime. The goal of the control is to have the BESS provide as much smoothing as possible so that the wind farm can be dispatched on an hourly basis based on the forecasted wind conditions. The effectiveness of this control strategy has been tested by using an actual wind farm data. Finally, it is shown that the control strategy is very important in determining the proper BESS size needed for this application.
The Economics of Behavioral Health Services in Medical Settings: A Summary of the Evidence

The health care system in the United States, plagued by spiraling costs, unequal access, and uneven quality, can find its best chance of improving the health of the population through the improvement of behavioral health services. It is in this area that the largest potential payoff in reduction of morbidity and mortality and increased cost-effectiveness of care can be found. A review of the evidence shows that many forms of behavioral health services, particularly when delivered as part of primary medical care, can be central to such an improvement. The evidence supports many but not all behavioral health services when delivered in settings in which people will accept these services under particular administrative and fiscal structures.
Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression1

The hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is an immune system modulator and induces expression of the TLR coreceptor CD14. 1,25(OH)2D3 signals through the vitamin D receptor, a ligand-stimulated transcription factor that recognizes specific DNA sequences called vitamin D response elements. In this study, we show that 1,25(OH)2D3 is a direct regulator of antimicrobial innate immune responses. The promoters of the human cathelicidin antimicrobial peptide (camp) and defensin β2 (defB2) genes contain consensus vitamin D response elements that mediate 1,25(OH)2D3-dependent gene expression. 1,25(OH)2D3 induces antimicrobial peptide gene expression in isolated human keratinocytes, monocytes and neutrophils, and human cell lines, and 1,25(OH)2D3 along with LPS synergistically induce camp expression in neutrophils. Moreover, 1,25(OH)2D3 induces corresponding increases in antimicrobial proteins and secretion of antimicrobial activity against pathogens including Pseudomonas aeruginosa. 1,25(OH)2D3 thus directly regulates antimicrobial peptide gene expression, revealing the potential of its analogues in treatment of opportunistic infections.
Progression in psoriatic arthritis: role of time varying clinical indicators.

OBJECTIVE We have shown that the presence of 5 or more effusions and high medication use at first clinic visit predicted clinical progression in patients with psoriatic arthritis (PsA), while a low erythrocyte sedimentation rate (ESR) was "protective. " These clinical indicators will change over the course of a patient's disease. We investigated whether there is additional prognostic information available through monitoring these indicators at each clinic visit. METHODS A total of 365 patients with at least 2 followup visits at the PsA Clinic who did not have 10 or more damaged joints at first visit were included. Clinical assessments including the number of actively inflamed and damaged joints were carried out every 6-12 mo according to a standard protocol. The analysis used a generalized linear model that relates the number of damaged joints that developed between consecutive clinic visits to the information available at the first of the 2 visits, and in which the information was added to a baseline model including the first visit variables previously shown to be important. RESULTS Single factor analysis suggested that the addition of functional class, number of actively inflamed joints, and Lansbury index provide prognostic information for subsequent damage. The final multivariate model includes time varying information on the number of actively inflamed joints, functional class, and current damage, as well as first visit information on prior medication as predictive of progression of damage, plus male sex and a low ESR at first visit as "protective. " CONCLUSION Time varying predictors for damage are important and should be monitored longitudinally in patients with PsA.
The Impact Of Central Bank Intervention On The Profitability Of Technical Trading Rules In The Foreign Exchange Market In Kenya

This study examined the impact of central bank intervention on the profitability of technical trading rules. The study period was from July 1, 2007 to June 30, 2012. The study employed simple moving average rules with and without interest rate cost. Data was analyzed with central bank intervention data then the intervention data were removed and the data analyzed again. Then paired sample t-test was applied to profits with and without interest cost and to profits with and without central bank intervention. The general result that central bank intervention in the market reduces the profitability of technical trading rules is interesting. This result means that central bank intervention in the market can reduce speculation in the market. However, this can only be the case when the profits after intervention are not significant. As the results demonstrate above, indeed profits decline but they are still significant. Therefore central bank intervention has not been successful in eliminating speculation in the market. The results also show that central bank intervention reduces the volatility of technical trading profits. Therefore, when the central bank intervenes in the market speculators earn relatively low profits simply because exchange rate volatility has declined. This finding is supported by not only a decreased standard deviation but also a lower kurtosis. The impact of central bank intervention in the market is only felt at the monthly trading interval. Thus, intervention in the foreign exchange market does not significantly reduce profitability of technical trading rules and hence speculation. Thus, the foreign exchange market is subject to large exchange rate movements with or without intervention by the central bank. The results show that including interest rate costs does not eliminate the profitability of technical trading. Also technical trading appears more profitable during periods of high volatility.
Growth and buoyant density of Escherichia coli at very low osmolarities

The growth and buoyant densities of two closely related strains of Escherichia coli in M9-glucose medium that was diluted to produce osmolarities that varied from as low as 5 to 500 mosM were monitored. At 15 mosM, the lowest osmolarity at which buoyant density could be measured reproducibly in Percoll gradients, both ML3 and ML308 had a buoyant density of about 1.079 g/ml. As the osmolarity of the medium was increased, the buoyant density also increased linearly up to about 125 mosM, at which the buoyant density was 1.089 g/ml. From 150 up to 500 mosM, the buoyant density again increased linearly but with a different slope from that seen at the lower osmolarities. The buoyant density at 150 mosM was about 1.091 g/ml, and at 500 mosM it was 1.101 g/ml. Both strains of E. coli could be grown in M9 medium diluted 1:1 with water, with an osmolarity of 120 mosM, but neither strain grew in 1:2-diluted M9 if the cells were pregrown in undiluted M9. (Note: undiluted M9 as prepared here has an osmolarity of about 250 mosM.) However, if the cells were pregrown in 30% M9, about 75 mosM, they would then grow in M9 at 45 mosM and above but not below 40 mosM. To determine which constituent of M9 medium was being diluted to such a low level that it inhibited growth, diluted M9 was prepared with each constituent added back singly. From this study, it was determined that both Ca2+ and Mg2+ could stimulate growth below 40 mosM. With Ca2+ - and Mg2+ -supplemented diluted M9 and cells pregrown in 75 mosM M9, it was possible to grow ML308 in 15 mosM M9. Strain ML3 would only haltingly grow at 15 mosM. Four attempts were made to grow both ML3 and ML308 at 5 mosM. In three of the experiments, ML308 grew, while strain ML3 grew in one experiment. While our experiments were designed to effect variations in medium osmolarity by using NaCl as an osmotic agent, osmolarity and salinity were changed concurrently. Therefore, from this study, we believe that E. coli might be defined as an euryhalinic and/or euryosmotic bacterium because of its ability to grow in a wide range of salinities and osmolarities.
The Treacherous Path of Corporate Social Responsibility (CSR) and the Role of Information Systems in Its Implementation

Despite alleged widespread adoption of Corporate Social Responsibility (CSR) and responsible business practices by organisations worldwide, questions still remain on the motives for such adoption; effects and/or benefits of CSR adoption as well as how stakeholders can tell genuine responsible businesses from those paying lip service and using the CSR tag as a ‘means-to-an end'. The litany of jargon often used interchangeably including such terms as CSR, sustainability, sustainable marketing, responsible business practice and sustainable development among others further lead to scepticism on organisations' commitments to CSR and the resultant allegations of greenwashing and CSR tokenism. This undermines genuine attempts to be corporately-responsible, fuelling confusion for any new players wishing to adopt responsible business practices. This chapter uses the Information Systems (IS) landscape as a lever to dissect issues in both CSR theory and practice, offering some practical guidelines for implementation and operationalisation, while raising further questions for research.
The application of Model Predictive Control to normalize glycemia of critically ill patients

In this paper we propose a Model based Predictive Controller (MPC) to be used for glycemia control in critically ill patients. A model, that is particularly developed for describing the glucose and the insulin dynamics of these patients, is estimated for each individual patient and re-estimated as new measurements are obtained. Both a quantitative and a qualitative analysis are performed with respect to a real-life dataset from 19 critically ill patients. In the first analysis the robustness of the MPC is tested assuming a once per hour or a once per four hours insulin adaptation frequency is imposed. The second analysis is characterized by a comparison between the MPC insulin infusion sequence and the insulin flows (determined by the nurse) that were effectively administered to the patient. The contribution of this paper is the development of an MPC for glycemia control in the Intensive Care Unit (ICU). The penalty index, which is a specific concept for quantitative analysis of glycemia control in the ICU, is also proposed. The results of the developed MPC are satisfactory both in terms of control behavior (reference tracking and the suppression of unknown disturbance factors) and clinical acceptability.
Eye Blink Responses to the Four Basic Taste Stimuli in Healthy Young Humans

Taste stimuli can elicit facial responses, and the facial responses may be useful indexes of taste sensations. In this study, we propose that eye blinking is also elicited by taste stimuli and we examined eye blink responses in six healthy young adults. Low and high concentration solutions of the four basic taste qualities (sweetness, saltiness, sourness, and bitterness) and distilled water were delivered via a silicone tube. Facial responses were recorded by a video camera and eye blink responses were identified. The number of eye blinks in the 5 s following stimulation, and the latency and duration of the first eye blink, were quantified. High concentrations of sour and bitter solutions increased the number of eye blinks (195% and 227%, respectively; P P P
Experimental support for the trajectorial theory of bone structure.

1. Rosette strain gauges placed on the lateral surface of the right calcaneus of eight sheep allowed recordings of bone deformation to be made during walking and trotting on a moving belt. From these recordings the changing direction and magnitude of the principal strains and the maximum shear strain could be calculated. 2. The cancellous architecture of the ovine calcaneus, when viewed in lateral radiographs, is arranged in two trabecular tracts which intersect in the form of an arch. in all cases during the main weight-bearing period the direction of the principal strains varied little, and at the time of maximum deformation coincided with the direction of the underlying trabeculae. The principal compressive strain coincided with the direction of the trabeculae in the dorsal tract, The principal tensile strain with those in the plantar tract. At the point of trabecular intersection the principal strains were more nearly equal but they maintained their alignment with their respective trabecular tracts. 3. in this particular site the trajectorial theory of bone structure has found some experimental support.
Enablers of Sustainable Manufacturing Overview, Framework and Further Research Directions

The aim of this paper is to develop a conceptual sustainable manufacturing (SM) framework, which is the pressing need of highly competitive and natural resource scarce world. Systematic literature review has been adopted to identify enablers of SM. The enablers identified through systematic literature review includes product design, material selection & procurement, customer requirements, regulatory norms, social values & ethics, environmental priorities, energy costs, natural resource scarcity, supply chain & logistics systems, fuel price regulations, public awareness, technology and total quality management. Author has attempted to develop a contextual relationship among enablers of SM using interpretive structural modeling. The author has further classified enablers into four categories using MICMAC analysis. The author has also outlined the limitations of present study and identified further research directions.