Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychologic Effects of Cardiovascular Conditioning: A Controlled Experiment

&NA; Although there have been numerous studies documenting a relationship between physical fitness and psychologic functioning, few have employed the type of experimental design that would allow conclusions to be drawn regarding cause and effect. In the present study, college students were randomly assigned to a cardiovascular conditioning program or to a control program designed to give the appearance of physical training while minimizing cardiovascular benefits. Both groups were tested for cardiovascular fitness as well as on a number of self‐rating scales before and after the 6‐week program. The cardiovascular group demonstrated a significantly greater improvement in cardiovascular fitness than the control group and also tended to show a greater reduction in anxiety and greater increase in measures of general psychologic well‐being.
CONTROL OF A CLAMPED-FREE BEAM BY A PIEZOELECTRIC ACTUATOR

We consider a controllability problem for a beam, clamped at one boundary and free at the other boundary, with an attached piezoelectric actuator. By Hilbert Uniqueness Method (HUM) and new results on diophantine approximations, we prove that the space of exactly initial controllable data depends on the location of the actuator. We also illustrate these results with numerical simulations.
The promise of receptor studies in psychophysiologic research.

&NA; Most research on reactivity to stressors limits its focus to the neurohormonal and cardiovascular components of reactivity. There is, however, another area of investigation with important implications to this field. Receptor binding techniques provide a direct measure of the functional link between neurohormonal signals and the responses they stimulate. Receptor measurement would enable psychophysiologic studies to begin to address the complete triad of signal emission/reception/end‐organ response that underlies all reactivity patterns. This paper reviews adrenergic receptor physiology, methods, and research pertinent to reactivity. Our intention is to encourage greater consideration of these important issues in reactivity research.
CALL FOR PAPERS Exercise Training in Cardiovascular Disease: Mechanisms and Outcomes Chronic endurance exercise affects paracrine action of CD31 and CD34 cells on endothelial tube formation

Landers-Ramos RQ, Sapp RM, Jenkins NT, Murphy AE, Cancre L, Chin ER, Spangenburg EE, Hagberg JM. Chronic endurance exercise affects paracrine action of CD31 and CD34 cells on endothelial tube formation. Am J Physiol Heart Circ Physiol 309: H407–H420, 2015. First published June 8, 2015; doi:10.1152/ajpheart.00123. 2015. —We aimed to determine if chronic endurance-exercise habits affected redox status and paracrine function of CD34 and CD34 /CD31 circulating angiogenic cells (CACs). Subjects were healthy, nonsmoking men and women aged 18–35 yr and categorized by chronic physical activity habits. Blood was drawn from each subject for isolation and culture of CD34 and CD34 / CD31 CACs. No differences in redox status were found in any group across either cell type. Conditioned media (CM) was generated from the cultured CACs and used in an in vitro human umbilical vein endothelial cell-based tube assay. CM from CD34 cells from inactive individuals resulted in tube structures that were 29% shorter in length (P 0.05) and 45% less complex (P 0.05) than the endurance-trained group. CD34 /CD31 CM from inactive subjects resulted in tube structures that were 26% shorter in length (P 0.05) and 42% less complex (P 0.05) than endurance-trained individuals. Proteomics analyses identified S100A8 and S100A9 in the CM. S100A9 levels were 103% higher (P 0.05) and S100A8 was 97% higher in the CD34 /CD31 CM of inactive subjects compared with their endurance-trained counterparts with no significant differences in either protein in the CM of CD34 CACs as a function of training status. Recombinant S100A8/A9 treatment at concentrations detected in inactive subjects’ CD34 /CD31 CAC CM also reduced tube formation (P 0.05). These findings are the first, to our knowledge, to demonstrate a differential paracrine role in CD34 and CD34 / CD31 CACs on tube formation as a function of chronic physical activity habits and identifies a differential secretion of S100A9 by CD34 /CD31 CACs due to habitual exercise.
Distal Adding-on and Risk Factors in Severe and Rigid Scoliosis

Study Design. A retrospective study. Objective. The aim of this study was to identify associated risk factors of distal adding-on in severe and rigid scoliosis. Summary of Background Data. Previous work has evaluated the challenges in the treatment of patients with severe and rigid scoliosis and the risks of complications. Furthermore, although several studies have investigated postoperative distal adding-on and attendant risk factors in Lenke type 1A scoliosis, very few have focused on distal adding-on in severe and rigid scoliosis. Methods. In this study, 48 consecutive patients with severe and rigid scoliosis underwent posterior spinal fusion surgery. The parameters of preoperative, immediately postoperative, and minimum 2-year follow-up radiographs were evaluated. The patients were classified as positive or negative for distal adding-on at follow-up, and risk factors were comparatively analyzed in the two groups. Results. The average Cobb angle and flexibility of the main thoracic curve (MTC) were 107.4° ± 15.9° and 16.4% ± 10.2%, respectively, before surgery. Distal adding-on was observed in 12 patients (25.0%) at follow-up. Univariate analysis identified several factors significantly associated with distal adding-on. Furthermore, significant independent risk factors identified by stepwise logistic regression analysis included the correction rate of the MTC immediately after surgery (odds ratio: 1.107, 95% confidence interval: 1.024–1.197, P = 0.011) and the difference between the lower instrumented vertebra (LIV) and last touching vertebra (LTV) levels (odds ratio: 0.121, 95% confidence interval: 0.028–0.518, P = 0.004). Conclusion. In severe and rigid scoliosis, a high correction rate of the MTC immediately after surgery and the LIV level above the LTV were significantly associated with distal adding-on. Level of Evidence: 3
Employment With A Human Face Balancing Efficiency Equity And Voice

Thank you for downloading employment with a human face balancing efficiency equity and voice. Maybe you have knowledge that, people have search hundreds times for their favorite readings like this employment with a human face balancing efficiency equity and voice, but end up in harmful downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they are facing with some infectious virus inside their computer.
Persistent Headache after Supratentorial Craniotomy

OBJECTIVEAlthough the incidence, possible causes, and treatment of persistent headache after suboccipital craniotomy have been discussed extensively, few data have been published regarding persistent headache after supratentorial craniotomy. METHODSWe retrospectively analyzed the senior author’s patient series of 145 consecutive anterior temporal lobectomies for intractable epilepsy performed during a 9-year period. To eliminate confounding causes of headache, all patients studied were seizure-free, none had progressive mass lesions or persisting vascular anomalies, and none had major complications of surgery. With the permission of the institutional review board, information on headache was obtained from patient records, the patients’ neurologists, and the patients themselves. RESULTSOf the 145 consecutive patients who underwent operations, 126 patients had adequate follow-up for analysis. Of the 126 patients, 104 did not have headaches and were not using regular analgesics 2 months postoperatively. Twenty-two patients had headaches persisting beyond 2 months. Seven (5.6%) of the 126 patients had headaches that lasted more than 2 months but less than 1 year, and they were free of recurrent headaches 1 year postoperatively. Fifteen (11.9%) of the 126 patients had ongoing headaches 1 year after surgery. Regarding headache severity, 4.0% of patients had medically uncontrolled headaches, and 3.2% continued to require prescription drugs for headaches 1 year postoperatively. CONCLUSIONAlthough the incidence of persistent head pain after supratentorial craniotomy is lower than that reported for posterior fossa procedures, the incidence is not trivial. The cause of persistent pain deserves further investigation.
A pilot study on patch sensor based Photo Plethysmography (PPG) for heart rate measurements

The advent of Integrated Healthcare technology has helped in the development of portable medical devices for measuring vital physiological parameters such as such as Blood glucose and Blood pressure etc. These devices can be afforded by the common man and are readily available in the market. Medical devices of this kind give the firsthand information about the health condition of the patient and also suggests patient if any necessary actions need to be taken based on the observed symptoms. Although several attempts have been made to develop wearable non-invasive medical devices, still there is a huge demand to catch the need of resources constrained population. This paper suggests the design of a wearable patch sensor based on Photo Plethysmography (PPG) unit which can be used as a patch sensor or a wearable device for measuring the heart rate of the patient. The device consists of a sensor developed by Maxim Integrated Circuit for acquiring the PPG signal. The heart rate obtained from the PPG device is communicated serially to Arduino Processor using I2C serial communication, also accelerometer is embedded with the system for detecting undesirable hand movement while measuring heart rate from the signal derived from the PPG device. The Arduino Processor is also connected with the blue tooth model for further communication. The sensor can be placed either in cloth or in thin rubber sheet such that total unit can be tied around the wrist or can be designed place in any other part of the body were PPG signal can be recorded. From the preliminary pilot study, it can be concluded that the proposed patch sensor based PPG yields promising results for the measurement of heart rate. The device needs to be validated with large sample size before introducing to the clinical trial.
17β-Estradiol Potentiates Kainate-Induced Currents via Activation of the cAMP Cascade

Evidence for nongenomic actions of steroids is now coming from a variety of fields of steroid research. Mechanisms of steroid action are being studied with regard to the membrane receptors and the activation of second messengers. The present study investigated the mechanism for the rapid effect of estrogen on acutely dissociated hippocampal CA1 neurons by using the whole-cell, voltage-clamp recording. Under the perforated patch configuration, 17β-estradiol potentiated kainate-induced currents in 38% of tested neurons. The potentiation was stereospecific, rapid in onset, and reversible after the removal of the steroid. Dose–response curves show that the potentiation by 17β-estradiol was evident at a concentration as low as 10 nm and saturated at 10 μm. 17β-Estradiol did not affect the kinetics (i.e., affinity and cooperativity) and reversal potential of kainate-induced currents. This suggests that the potentiation did not result from direct interaction with kainate receptors nor the activation of ion channels other than kainate receptor-channels. The potentiation by 17β-estradiol was similar to the enhancement of kainate-induced currents evoked by 8-bromo-cAMP, and was modulated by an inhibitor of phosphodiesterase (IBMX). The estrogen potentiation was blocked by a specific blocker of PKA (Rp-cAMPS). Under standard recording configuration, the effect was significantly affected by intracellular perfusing with GDP-β-S or GTP-γ-S. The data suggest that the potentiation of kainate-induced currents by 17β-estradiol was likely a G-protein(s) coupled, cAMP-dependent phosphorylation event. By involvement of this nongenomic mechanism, estrogen may play a role in the modulation of excitatory synaptic transmission in the hippocampus.
RANKL expression in a case of follicular lymphoma

Abstract: The TNF‐family molecule, RANKL, is a key regulator of bone remodeling and essential for the development and activation of osteoclasis. Bone involvement signals diesease activity in non‐Hodgkin's lymphoma and influences the progenesis. The molecular mechanism and soluble factors involved in osteoclastic activation in haematological malignancies remain unclear except for Multiple Myeloma and Adult T‐cell Leukemia. The aim of this paper is to report the first case of Follicular Lymphoma with bone involvement displaying an aberrant expression of RANKL in malignant cells. The detection of RANKL in Follicullar Lymphoma may help to prevent bone lesion in patients by determining an appropriate treatment.
1292PALK INHIBITOR AP26113 IN PATIENTS WITH ADVANCED MALIGNANCIES, INCLUDING ALK+ NON-SMALL CELL LUNG CANCER (NSCLC): UPDATED EFFICACY AND SAFETY DATA.

ABSTRACT Aim: AP26113 is an investigational orally-active tyrosine kinase inhibitor with preclinical activity against ALK and all 9 clinically-identified crizotinib-resistant mutants tested. Methods: The Phase (Ph) 2 portion of a Ph1/2 single arm, multicenter study in patients (pts) with advanced malignancies is underway. We report updated safety for all treated pts and efficacy data for ALK+ NSCLC pts previously treated with crizotinib. NCT01449461. Results: As of 17 March 2014, 125 pts were enrolled: 66 in Ph1 (30-300 mg) and 59 in Ph2 (90 or 180 mg). Baseline characteristics: 58% female, median age 57 yr; diagnoses: NSCLC n = 117, other n = 8. 62 pts remain on study; median follow-up for all pts is 3.1 mo (max= 24.4 mo, ongoing). The most common treatment-emergent adverse events (≥20%) were nausea (40%), fatigue (34%), diarrhea (34%), cough (26%), headache (25%), and vomiting (21%), which were generally Grade 1/2 in severity. Early onset pulmonary symptoms (dyspnea with hypoxia and/or new findings on chest imaging) were observed in 12/125 (10%) pts: 6/44 (14%) at 180 mg qd and 1/38 (3%) at 90 mg qd. Symptoms occurred within 7 days following initiation of AP26113, required medical attention, and occurred at lower rates with lower doses. Pts continue to be enrolled at 90 mg qd. Among 51 evaluable ALK+ NSCLC pts with prior crizotinib, 35 (69%) responded. Duration of response was 1.6– 14.7+ mo. 23 had confirmed responses and 7 await confirmation. Among 55 evaluable pts with ALK+ NSCLC, median progression free survival is 10.9 mo. Independent radiological review conducted on 10 pts enrolled with untreated or progressing brain metastases showed 6/10 pts with regression in brain, including 4 with undetectable brain metastases following AP26113; 2 had stable disease, 2 progressed; 7/10 remain on study (range 2.7-19.5 mo). Updated data will be presented. Conclusions: AP26113 has promising anti-tumor activity in pts with crizotinib-resistant ALK+ NSCLC, including pts with brain metastases. A randomized Ph2 trial evaluating either 90 mg qd or 90mg qd escalated to 180 mg qd in crizotinib-resistant ALK+ NSCLC has been initiated. Disclosure: S. Gettinger: research funding (ARIAD); consultancy (ARIAD); honoraria (ARIAD); C. Langer: research funding (ARIAD); A. Shaw: consultancy (ARIAD); G.J. Weiss: consultancy (Genentech, Pfizer, Celgene, Quintiles, Medscape); N.I. Narasimhan: employment and equity ownership (ARIAD); D.J. Dorer: employment and equity ownership (ARIAD); V.M. Rivera: employment and equity ownership (ARIAD); T. Clackson: employment and equity ownership (ARIAD); F.G. Haluska: employment and equity ownership (ARIAD); R. Camidge: research funding (ARIAD); honoraria (ARIAD). All other authors have declared no conflicts of interest.
Automobile-based SAR/InSAR system for ground experiments

An automobile-based synthetic aperture radar (SAR) system named AutoSAR is described. It is an experimental SAR system operating on the ground, which was developed by the Pohang University of Science and Technology, Korea. AutoSAR can also operate as an interferometric SAR (InSAR) when one additional receiving antenna is used. The swath of AutoSAR is less than 1 km, and the azimuthal coverage is limited only by the storage capacity of the system. SAR and InSAR images obtained at a test site near Pohang, Korea, are presented. Being on an automobile, this system can easily obtain SAR data of any target area with a straight road nearby
Market Share and Profitability: Is Bigger Really Better?

The notion that large firms enjoy com petitive advantages over their smaller coun terparts has become part of the conventional wisdom in business strategy. During the last decade, high market share became increas ingly viewed as a prerequisite for success. While there are many reasons to expect large firms to demonstrate high profitability, there can be striking exceptions to the rule. In deed, generalizations about the attractive ness of seeking high market share may prove misleading to strategic planners. This arti cle will present evidence that, while market share and profitability do seem positively re lated on average, this relationship is weak overall and in many industries non-existent.
Zara: The international success of fast-moving fashion

This case study focuses on the international marketing policy of the Zara brand (Inditex group). Thanks to its specific business model, the fast-moving fashion, the group has become a leading player on the global clothing market. Today, Zara sells its products in 88 countries and is seeking new growth opportunities in emerging markets. In a highly competitive environment, the company reconsiders the main lines of its international marketing policy. The student is asked to analyse the internationalisation strategy of the group, propose an international marketing policy and assess the interest of selling Zara collections online. This case-study is the updated version of the case M1705 (GB) "Zara: The international success of fast-moving fashion".
One-stage anatomic double bundle anterior and posterior cruciate ligament reconstruction.

INTRODUCTION Main evidence of the heavy knee dislocations is the rupture of both Anterior Cruciate Ligament (ACL) and Posterior Cruciate Ligament (PCL). There are limited sources for the treatment of both ligaments at a single stage. Materials-method: One-staged anatomic double-bundle ACL and PCL reconstruction technique has been applied to 2 cases aged 20 and 36 with traumatic knee dislocation. Lateral collateral ligament and posteriolateral corner reconstruction added to one case, and medial collateral ligament and posteriomedial corner reconstruction for the other case. Because of additional femur fractures of the both cases, ligament reconstructions have been applied after the main treatment. Anterior tibialis tendon (ATT) allograft has been used for graft for both cases because of other stabilization deficiencies of knees. It has been confirmed that femoral and tibial tunnels constructed with anatomic double-bundle technique are fitting to anatomic locations by the post-operation CT results. Post fixation screw has been used for tibia, and endobutton at femur. RESULTS Tracking records of patients at 8th month shows that; Lysholm score of the case aged 20 was 89, and 85 for the case aged 36. While KT-1000 values was 3.7 mm, and 4.1 mm for 15 N power; and 9.1 mm-9.6 mm with the maximum power. CONCLUSION Surgical technical details of one-staged double-bundle reconstruction for ACL and PCL injuries which is gaining popularity recently has been stated.
Left or Right Hemisphere? A Novel Answer to the Old Question of Lateralization by Introducing IRL (Individualistic Relativistic Lateralization)

Although lateralization for language functions gives the sheer authority of language centers and control to the left hemisphere, there is a strong debate among the specialists regarding which hemisphere has the responsibility for language. There is not a complete meeting ground among the scholars on the roles of each hemisphere in language processes either. The recent studies including the advanced technologies such as neuroimaging, Positron-emission Tomography (PET) and functional MRI come up with contradictory findings that do not support the long time claim of left hemisphere dominance. Generally, this paper aims at finding a novel answer to the old question of lateralization in language acquisition. More particularly, first it attempts to review the latest researches to see the role of left and right hemispheres in language processes. Second, it introduces a novel version of lateralization as IRL (Individualistic Relativistic Lateralization) that rejects the notion of "left-brain only” and “right-brain only” person and functioning and accordingly rejects also the absolute generalizeable perspective to lateralization and localization.
Association of thyrotrophin receptor antibodies with the clinical features of Graves' ophthalmopathy

Graves' ophthalmopathy (GO) and Graves' hyperthyroidism are closely associated diseases and thought to be caused by the same autoimmune process. An obvious explanation for this would be the presence of autoantibodies reacting with an autoantigen present in the orbit and the thyroid gland. The TSH‐Receptor (TSH‐R) antibodies are a likely candidate, because they cause Graves' hyperthyroidism and the TSH‐R appears to be present also in orbital tissues. If TSH‐R antibodies are responsible for the ophthalmopathy one would expect their titres to correlate with clinical characteristics of the eye disease. The aim of the present study is to see whether TSH‐R antibodies are related to the activity and severity of the thyroid‐associated ophthalmopathy.
Peripheral endotoxin induces hypothalamic immunoreactive interleukin‐1β in the rat

Interleukin‐1 (IL‐1) is a polypeptide produced by a variety of cells and contributes to the general host response to inflammation. It displays a wide spectrum of inflammatory, metabolic, physiological, haematopoietic and immunological activities. Brain cells, including neurones, microglia, endothelial cells and astrocytes can all produce IL‐1β in response to various physiological and pathological stimuli. In this report we show that peripherally administered endotoxin stimulates the appearance of immunoreactive IL‐1β (IL‐1β) in the rat hypothalamus as measured by an ultrasensitive, highly specific enzyme amplified immunometric assay for rat IL‐1β.
Ampicillin plus Ceftriaxone for High-Level Aminoglycoside-Resistant Enterococcus faecalis Endocarditis

TO THE EDITOR: The antimicrobial synergism of ampicillin plus ceftriaxone to treat high-level aminoglycoside-resistant (HLAR) Enterococcus faecalis endocarditis, as shown by Gavald and colleagues (1), is important. However, certain basic questions need to be answered before this treatment can be incorporated into everyday practice. First, enterococci are inherently resistant to cephalosporins, including ceftriaxone. Second, ampicillin and ceftriaxone are both -lactam antibiotics with a common mechanism of action: inhibition of synthesis of the bacterial peptidoglycan cell wall. Antimicrobial agents acting on different targets may enhance the overall antimicrobial activity. How then can there be synergism between these 2 drugs? Treatment of HLAR E. faecalis depends on precise determination of antibiotic susceptibilities, testing for bactericidal activity, ascertainment of the serum inhibitory and bactericidal titers, and monitoring of drug concentrations in the serum. Although aminoglycoside resistance is often present, these drugs can still synergize with cell-wall inhibitors, provided that the aminoglycoside's minimal inhibitory concentration is 1000 mg/L or less (2). Streptomycin is worth testing because it can be active against enterococci that are resistant to other aminoglycosides (3). The cure rate for HLAR E. faecalis in Gavald and colleagues' study was 52% with ampicillin plus ceftriaxone combination therapy, which does not differ from the 40% to 50% cure rate with cell-wallsusceptible agent monotherapy (4).