Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Long-term Hormone Replacement Therapy on In vivo and In vitro Markers of Lipid Oxidation

Postmenopausal hormone replacement therapy (HRT) with estrogen has been suggested to inhibit oxidation of low-density lipoprotein (LDL) in vitro, but progestins may oppose this effect. We studied whether estrogen HRT and combined HRT with estrogen and progestin differ in their ability to resist in vivo and in vitro oxidation of lipids. Study group included 15 women on oestradiol valerate (mean age 56 years, treatment duration 10.5 years) and 15 women on combined HRT with oestradiol valerate and levonorgestrel (mean age 58 years, treatment duration 11.3 years). In addition to lipid and apolipoprotein concentrations, the lagtime of LDL to oxidation, the rate of the propagation phase and the maximum concentration of conjugated dienes were recorded as indices of LDL susceptibility to copper-induced oxidation in vitro. As an in vivo marker of oxidative stress we measured 24-h excretion of urinary 8-iso-prostaglandin F2α (8-iso-PGF2α). All measurements were done after long-term HRT (baseline), after 4 weeks pause and again 3 weeks after reintroduction of HRT. High-density lipoprotein (HDL) cholesterol and apolipoprotein AI concentrations were significantly higher and LDL to HDL ratio significantly lower after long-term oestradiol valerate therapy than after combined therapy. Simultaneously, the triglyceride and lipoprotein (a) levels were higher in the estrogen group. Susceptibility of LDL to oxidation and the level of 8-iso-PGF2α were similar in both groups at all measurement points, and treatment group was not a statistically significant determinant of these markers at baseline. According to these results, estrogen and combined HRT do not differ in their abilities to oppose LDL oxidation in vitro or systemic oxidative stress in vivo, but have differential effects on blood lipids.
De l'approche lexiculturelle des dictionnaires monolingues : le nouveau Petit Robert 2010, version électronique

Preconisee dans les annees 1980, la lexiculture, issue des travaux de Robert Galisson, s’est imposee ces dernieres decennies comme une notion incontournable dans l’enseignement/apprentissage des langues-cultures. Cette approche, rebaptisee pragmatique lexiculturelle a l’aube du nouveau siecle, ne cesse actuellement d’ouvrir la voie a de nombreux travaux tant du cote des dictionnaires monolingues d’apprentissage que bilingues et specialises. L’objet de cette etude est d’observer quelques aspects de la lexiculture au sein des dictionnaires generaux, en insistant notamment sur la facon dont les exemples forges permettent d’apprehender la culture. Plus precisement, on s’attardera a reperer dans le Petit Robert 2010, version web, quelques exemples de mots a charge culturelle partagee, sans negliger d’autres sites lexiculturels cernes par Galisson tels que les mots occultants et les mots-valises. Nous envisageons, entre autres, de clore cet article sur un examen de la lexiculture focalise sur la problematique eminemment enonciative des interjections.
Attrition and Eruption Rates of the Rat Lower Incisor

The attrition rate (A R), impeded eruption rate (IER), and unimpeded eruption rate (UER) of the rat incisor were measured for a period of 20 weeks to extend previous studies of these rates. After being weaned at 6 weeks, 20 Sprague-Dawley rats were divided into two groups, each containing five males and five females, and then maintained on a synthetic diet (T. MOORE, Vitamin A [ed. 1, 19571, p. 565) supplemented with vitamins. In the first group, AR and IER of both lower incisors were measured weekly. In the second group, AR and IER were measured weekly in the right incisor. UER measurements were made twice-weekly in the left incisor and the tooth shortened so as to remain well free of occlusion between measurements. The weekly AR and IER were measured by making a fine horizontal mark with a scalpel on the labia] enamel, and the change in distance from the mark to the incisal edge gave AR, while that from the mark to the gingival margin gave IER. Two methods were used to measure UER-that of Bryer (Int. dent. J., 7:432-78, 1957) and a gingival method, in which the change in distance from the cut edge of the left incisor to its gingival margin was determined. All rates "ere measured using a binocular microscope (incorporating a micrometer gauge) positioned perpendicular to the incisors. The values of AR and IER in the second group were lower than those in the first (table); this confirmed a result of Taylor and Butcher (J. exp. Zotl., 117:165-88, 1951), but differed somewhat from findings of Ness in the adult rabbit (Proc. R. Soc. B. ,
Simulating artificial cities in a GIS environment: urban growth under alternative regulation regimes

This paper reports on an attempt to combine neo-classical urban economic theory with complex systems methods. The innovative feature of our model from the point of view of conventional economic theory lies in its explicit treatment of spatial relationships and time sequence. From the perspective of raster or cellular GIS models of urban processes, the work is innovative in that it replaces the more usual heuristic cell-transition rules with micro-economic theory. The mix of modelling paradigms is not unproblematic, however, and we discuss the challenges encountered at this research frontier. These notwithstanding, our hybrid model has the potential to be used as a GIS-based laboratory for exploring micro-economic propositions, particularly those relating to urban processes that are path dependent. The version of the model reported simulates spatially equilibriated path dependent futures of a city governed by local development decisions that are at partial equilibria in the neo-classical sense. Two simulations are described which permit visual and economic exploration of (a) an explicitly spatial version of the economic theory of externalities and (b) a new theory of densification. The dual paradigm (Cellular Automata-neo-classical economics) leads to an interesting class of simulations in terms of stability. Economically our simulated cities become increasingly efficient, in terms of private and social product. The long-run economic equilibrium is achieved by many individually efficient negotiations based only on local information. There is no parallel long-run spatial equilibrium however. The spatial configuration of land uses is constantly shifting as a result of randomness in the land use bidding process. The spatial instability is, however, limited by the self-organised drive for greater overall economic efficiency. In economic terms, the model's spatial instability represents random re-allocation of land-use within a set of Pareto-efficient spatial configurations - an intriguing result that we intend to follow up in future work.
Quantum Inspired Algorithm for a VRP with Heterogeneous Fleet Mixed Backhauls and Time Windows

This paper presents a new Quantum Inspired Harmony Search algorithm with Variable Population Size QIHSVPS for a complex variant of vehicle routing problem VRP, called HVRPMBTW Vehicle Routing Problem with Heterogeneous fleet, Mixed Backhauls and Time Windows. This variant is characterized by a limited number of vehicles with various capacities and costs. The vehicles serve two types of customers: linehauls customers and backhauls customers. Each customer must be visited in a specific interval of time. The authors propose to use quantum principles to accelerate evolution process and variable population size to decrease the number of solution's evaluation, when the improvement is insignificant. This new approach was tested on benchmarks and produces satisfactory results compared to other approaches.
Genotoxicity and physicochemical characteristics of traffic‐related ambient particulate matter

Exposure to ambient particulate matter (PM) has been linked to several adverse health effects. Since vehicular traffic is a PM source of growing importance, we sampled total suspended particulate (TSP), PM10, and PM2.5 at six urban locations with pronounced differences in traffic intensity. The mutagenicity, DNA‐adduct formation, and induction of oxidative DNA damage by the samples were studied as genotoxicological parameters, in relation to polycyclic aromatic hydrocarbon (PAH) levels, elemental composition, and radical‐generating capacity (RGC) as chemical characteristics. We found pronounced differences in the genotoxicity and chemical characteristics of PM from the various locations, although we could not establish a correlation between traffic intensity and any of these characteristics for any of the PM size fractions. Therefore, the differences between locations may be due to local sources of PM, other than traffic. The concentration of total (carcinogenic) PAHs correlated positively with RGC, direct and S9‐mediated mutagenicity, as well as the induction of DNA adducts and oxidative DNA damage. The interaction between total PAHs and transition metals correlated positively with DNA‐adduct formation, particularly from the PM2.5 fraction. RGC was not associated with one specific PM size fraction, but mutagenicity and DNA reactivity after metabolic activation were relatively high in PM10 and PM2.5, when compared with TSP. We conclude that the toxicological characteristics of urban PM samples show pronounced differences, even when PM concentrations at the sample sites are comparable. This implies that emission reduction strategies that take chemical and toxicological characteristics of PM into account may be useful for reducing the health risks associated with PM exposure. Environ. Mol. Mutagen. , 2005. © 2005 Wiley‐Liss, Inc.
[Urinary citrate excretion in children with calcium urolithiasis].

UNLABELLED Citrate is thought to be one of the most important inhibitor of calcium salts crystallization in the urine. Therefore, an assessment of urinary citrate excretion is an integral element of metabolic evaluation in urolithiasis. The reported incidence of urolithiasis associated with hypocitraturia varies from 10% to 63%. The purpose of the study was to assess urinary citrate excretion in children with calcium urolithiasis living in region of Lublin. The study comprised 60 children (34 boys and 26 girls) aged 4.3-18 years. In 36 of them, calcium oxalate urolithiasis was diagnosed by spectrophotometry. In the remaining children, an assessment of stone composition was impossible. However, in all children, stones were radiopaque. Hypercalciuria (HC) and mild hyperoxaluria (HOx) were diagnosed in 23 and 16 children, respectively. In the remaining 21 children urolihiasis was classified as idiopathic. The controls were 35 healthy age- and gender-matched children. Urinary citrate excretions were assessed by enzymatic method in 24-hour urine specimens and expressed as citrate/creatinine ratios (Cit/Cr). Decreased Cit/Cr were observed in 9 (15%) children with calcium urolithiasis. However, there was no significant difference between the mean Cit/ Cr in children with calcium urolithiasis and controls (410 +/- 207 mg/g vs 385 +/- 144 mg/g). There was also no significant difference between the mean Cit/ Cr in children with HC and controls. Similarly, the mean Cit/Cr did not differ significantly between children with HOx and controls. However, the lowest mean Cit/Cr was revealed in children with HOx (306 +/- 161 mg/g). CONCLUSIONS In most children with calcium urolithiasis urinary citrate excretion was normal. However, in some children with urolithiasis, detection of hypocitraturia allows to explain pathogenesis of stone formation and to carry on a causative prophylaxis.
Kurento: The Swiss Army Knife of WebRTC Media Servers

In this article we introduce Kurento, an open source WebRTC media server and a set of client APIs intended to simplify the development of applications with rich media capabilities for the Web and smartphone platforms. Kurento features include group communications, transcoding, recording, mixing, broadcasting and routing of audiovisual flows, but also provides advanced media processing capabilities such as computer vision and augmented reality. It is based on a modular architecture, which makes it possible for developers to extend and customize its native capabilities with third-party media processing algorithms. Thanks to all of this, Kurento can be a powerful tool for Web developers who may find natural programming with its Java and JavaScript APIs following the traditional three-tiered Web development model.
Cellular Angiolipoma: A Clinicopathological and Immunohistochemical Study of 12 Cases

Abstract:Cellular angiolipoma is a rare variant of angiolipoma. To date, only a few reports have been published in the literature. In this report, we analyzed a series of 12 cases to further evaluate this entity. Seven patients were men and 5 were women, aged from 23 to 62 years (average, 39 years). Clinically, the lesions occurred predominantly in the subcutaneous tissue of the extremities and trunk wall, usually as part of multiple small tender nodules. In 5 cases, cellular angioloipoma coexisted with the conventional angiolipoma. Histologically, the tumor differed from its conventional counterpart by containing densely cellular areas that occupied more than 90% of the tumors. By comparison, adipocytic component accounted only for a minimal portion (<10%). CD31 and CD34 immunostainings highlighted the rich vasculature in the cellular areas. In conclusion, the clinical and morphological overlaps between the cellular angiolipoma and its conventional counterpart indicate that they lie within the same spectrum of a single entity.
Forbearance and Broken Credit Cycles

This paper studies how post-…nancial-crisis economy diers from its pre-crisis period, by providing a microeconomic model of asset price, aggregate output and banks'strategic behaviour. Banks in this model rationally avoid liquidating non-performing loans to make up their balance sheets (i.e. forbearance or zombie lending), when realising loan losses would reduce their capitals lower than the regulatory threshold and force the banks to go bankrupt. But the forbearance comes at a macro-economic cost. Knowing that banks have to liquidate forborne non-performing loans some day, they expect the decrease of collateral asset value in the future, which constrains new lending to productive …rms. Forbearance thus decelerates de-leverage of less-productive sectors while it accelerates de-leveraging productive sectors, leading to the reduction of aggregate output. However, we also identify the possibility of output-boosting forbearance when the economy has a strong '…nancial accelerator eect'. By studying both banks'incentive of forbearance and its impacts on macro-economy and banking systems, this paper provides a rich model explaining some of post-crisis phenomena, such as low productivity, slow de-leverage in speci…c sectors, sluggish new lending, excessively resilient property prices, and broken correlation between asset price and output growth. The paper concludes with a welfare analysis of forbearance and a discussion on optimal policy measures.
Performance Issues in High Performance Fortran Implementations of Sensor-Based Applications

Applications that get their inputs from sensors are an important and often overlooked application domain for High Performance Fortran (HPF). Such sensor-based applications typically perform regular operations on dense arrays, and often have latency and through put requirements that can only be achieved with parallel machines. This article describes a study of sensor-based applications, including the fast Fourier transform, synthetic aperture radar imaging, narrowband tracking radar processing, multibaseline stereo imaging, and medical magnetic resonance imaging. The applications are written in a dialect of HPF developed at Carnegie Mellon, and are compiled by the Fx compiler for the Intel Paragon. The main results of the study are that (1) it is possible to realize good performance for realistic sensor-based applications written in HPF and (2) the performance of the applications is determined by the performance of three core operations: independent loops (i.e., loops with no dependences between iterations), reductions, and index permutations. The article discusses the implications for HPF implementations and introduces some simple tests that implementers and users can use to measure the efficiency of the loops, reductions, and index permutations generated by an HPF compiler.
Effect of 3D animation videos over 2D video projections in periodontal health education among dental students

Background: There is limited evidence about the distinguished effect of 3D oral health education videos over conventional 2 dimensional projections in improving oral health knowledge. This randomized controlled trial was done to test the effect of 3 dimensional oral health educational videos among first year dental students. Materials and Methods: 80 first year dental students were enrolled and divided into two groups (test and control). In the test group, 3D animation and in the control group, regular 2D video projections pertaining to periodontal anatomy, etiology, presenting conditions, preventive measures and treatment of periodontal problems were shown. Effect of 3D animation was evaluated by using a questionnaire consisting of 10 multiple choice questions given to all participants at baseline, immediately after and 1month after the intervention. Clinical parameters like Plaque Index (PI), Gingival Bleeding Index (GBI), and Oral Hygiene Index Simplified (OHI-S) were measured at baseline and 1 month follow up. Results: A significant difference in the post intervention knowledge scores was found between the groups as assessed by unpaired t-test (p<0.001) at baseline, immediate and after 1 month. At baseline, all the clinical parameters in the both the groups were similar and showed a significant reduction (p<0.001)p after 1 month, whereas no significant difference was noticed post intervention between the groups. Conclusion: 3D animation videos are more effective over 2D videos in periodontal disease education and knowledge recall. The application of 3D animation results also demonstrate a better visual comprehension for students and greater health care outcomes.
Preservice teachers' perceptions about using mobile phones and laptops in education as mobile learning tools

The purpose of this research was to investigate preservice teachers' perceptions about using m-phones and laptops in education as mobile learning tools. A total of 1087 preservice teachers participated in the study. The results indicated that preservice teachers perceived laptops potentially stronger than m-phones as m-learning tools. In terms of limitations the situation was balanced for laptops and m-phones. Generally, the attitudes towards using laptops in education were not exceedingly positive but significantly more positive than m-phones. It was also found that such variables as program/department, grade, gender and possessing a laptop are neutral in causing a practically significant difference in preservice teachers' views. The results imply an urgent need to grow awareness among participating student teachers towards the concept of m-learning, especially m-learning through m-phones. [ABSTRACT FROM AUTHOR]
Dobutamine stress cine‐MRI of cardiac function in the hearts of adult cardiomyocyte‐specific VEGF knockout mice

A mouse model of non‐necrotic vascular deficiency in the adult heart was studied using cine‐magnetic resonance imaging (MRI) and other techniques. The mice lacked cardiomyocyte‐derived vascular endothelial growth factor (VEGF) following a targeted knockout in the ventricular cardiomyocytes. Quantitative endothelial labeling showed that the capillary density was significantly reduced in the hearts of knockout mice. Gene expression patterns suggested that they were hypoxic. Semiautomated MR image analysis was employed to obtain both global and regional measurements of left ventricular function at 10 or more time points through the cardiac cycle. MRI measurements showed a marked reduction in ejection fraction both at rest and under low‐ and high‐dose dobutamine stress. Regional wall thickness, thickening, and displacement were all attenuated in the knockout mice. A prolonged high‐dose dobutamine challenge was monitored by MRI. A maximal response was sustained for 90 minutes, suggesting that it did not depend on endogenous glycogen stores. J. Magn. Reson. Imaging 2001;14:374–382. © 2001 Wiley‐Liss, Inc.
Non‐Hodgkin's lymphomas. V. Results of radiotherapy

Four hundred and five patients with non‐Hodgkin's lymphomas, referred between 1960 and 1971, were carefully evaluated for extent of disease prior to therapy. Tumors were histologically classified according to the criteria of Rappaport et al and patients staged by the criteria of the Ann Arbor Conference. Of 234 patients, Stages I‐IIIE, 215 received initial radiotherapy, 91% with a curative intent. Follow‐up time ranged from 1–12 years. Calculations were made of actuarial survival and disease‐free‐survival for each group of patients according to initial stage, histologic type of lymphoma, and type of radiotherapy. Patients with diffuse histiocytic (DH) lymphoma exhibited a 65% probability of tumor relapse during the first year of follow‐up in contrast to the 19% probability for comparably staged patients with nodular mixed histiocytic‐lymphocytic (NM) and nodular lymphocytic poorly differentiated (NLPD) lymphomas. Patients with diffuse mixed (DM), diffuse lymphocytic (DLPD), and nodular histiocytic (NH) lymphomas exhibited an intermediate risk of relapse during the first year (39‐45%). Patients with NM and NLPD manifested a pattern of continued late relapse whereas those with DH lymphoma seldom experienced new evidence of tumor after the first year of disease‐free observation. Patients with localized extralymphatic lymphoma (IE, IIE, IIIE) demonstrated patterns of clinical behavior following radiotherapy similar to those observed in patients whose lymphomas were confined to lymphatic tissue (I, II, III). The data offer strong support for the continued use of the Rappaport et al. histologic classification and the Ann Arbor clinical staging system in the radiotherapeutic managemement of patients with the non‐Hodgkin's lymphomas.
High-frequency electron paramagnetic resonance investigation of the Fe3+ impurity center in polycrystalline PbTiO3 in its ferroelectric phase

The intrinsic iron(III) impurity center in polycrystalline lead titanate was investigated by means of high-frequency electron paramagnetic resonance spectroscopy in order to determine the local-environment sensitive fine-structure parameter D. At a spectrometer frequency of 190GHz, a spectral analysis of a powder sample was unambiguously possible. The observed mean value D=+35.28GHz can be rationalized if Fe3+ ions substitute for Ti4+ at the B site of the perovskite ABO3 lattice forming a directly coordinated FeTi′–VO∙∙ defect associate. A consistent fit of the multifrequency data necessitated the use of a distribution of the D values with a variance of about 1GHz. This statistical distribution of values is probably related to more distant defects and vacancies.
Muscle fatigue assessment using one-channel single-element ultrasound transducer

In this paper, the thickness change of biceps brachii during the fatigue process is continuously monitored using one micro-size single-element ultrasound transducer and analyzed by the echo tracking algorithm. We focus on isometric, 50 % maximum voluntary contraction (MVC) of the elbow. Four subjects participates in the experiment and the result shows that the muscle thickness of biceps brachii continues to increase during the fatigue. There are two stages of the increasing process, the first of which sees a much higher increasing speed of the muscle thickness. Curve fitting using exponential functions is applied and the fitting result turns out to be good with the R2 of 0.96. The preliminary study reveals that those custom-made single-element transducers would effectively extract muscle information to assess muscle fatigue.