Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of Colletotrichum species associated with coffee berries in northern Thailand

International Fungal Research & Development Centre, The Research Institute of Resource Insects, Chinese Academy of Forestry, Bailongsi, Kunming 650224, PR China School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand Department of Biotechnology, Faculty of Agriculture, Brawijaya University, Malang 65145, Indonesia Novozymes China, No. 14, Xinxi Road, Shangdi, HaiDian, Beijing, 100085, PR China Landcare Research, Private Bag 92170, Auckland 1142, New Zealand
NQO1 is Required for Beta-lapachone-mediated Downregulation of Breast Cancer Stem Cell Activity

Background: Cancer stem cells (CSCs) exhibit self-renewal activity and give rise to other cell types in tumors. Due to the infinite proliferative potential of CSCs, drugs targeting these cells are necessary to completely inhibit cancer development. beta-lapachone (bL) has been widely used to treat cancer development, but its effect on cancer stem cells remain elusive. Thus, we investigated the effect of bL on mammosphere formation using breast cancer stem cell (BCSC) marker positive cells, MDA-MB-231. Methods: MDA-MB-231 Cells, which is negative for NQO1 expression, was constructed to stably express NQO1(NQO1 stable cells) to see the effect of bL. The effect of bL on cells were evaluated by wound healing and Transwell cell culture chambers, and ALDEFLUOR assay. Results: Here, we show that bL inhibited the proliferative ability of mammosphere derived from BCSC marker-positive cells, MDA-MB-231, in an NQO1-dependent manner. bL treatment efficiently downregulated expression level of BCSC markers CD44, ALDH1A1, and DLGAP5 that recently identified as a stem cell proliferation marker in both cultured cells and mammosphered cells. Moreover, bL efficiently downregulates cell proliferation and migration activities. Conclusions: These results strongly suggest that bL could be a therapeutic agent targeting breast cancer stem cells with proper NQO1 expression.
From buildings to point-line geometries and back again

A chamber system is a particular type of edge-labeled graph. We discu ss when such chamber systems are or are not associated with a geometry, and when they are buildings. Buildings can give rise to point-line geometries under constraints imposed by how a line should behave with respect to the point-shadows of the other geometric objects (Pasini (P)). A recent theorem o f Kasikova (K) shows that Pasini's choice is the right one. So, in a general w ay, one has a procedure for getting point-line geometries from buildings. In the other direction, we describe how a class of point-line geometries with elementary local axioms (certain parapolar spaces) successfully char- acterize many buildings and their homomorphic images. A recent result of K. Thas (KT) makes this theory free of Tits' the classification of polar spaces o f rank three (T1). One notes that parapolar spaces alone will not cover all o f the point-line geometries arising from buildings by the Pasini-Kasikova construction, so the door is wide open for further research with points and lines.
SIMULATIONS OF ACCRETION POWERED SUPERNOVAE IN THE PROGENITORS OF GAMMA-RAY BURSTS

Observational evidence suggests a link between long-duration gamma-ray bursts (LGRBs) and Type Ic supernovae. Here, we propose a potential mechanism for Type Ic supernovae in LGRB progenitors powered solely by accretion energy. We present spherically symmetric hydrodynamic simulations of the long-term accretion of a rotating gamma-ray burst progenitor star, a “collapsar,” onto the central compact object, which we take to be a black hole. The simulations were carried out with the adaptive mesh refinement code FLASH in one spatial dimension and with rotation, an explicit shear viscosity, and convection in the mixing length theory approximation. Once the accretion flow becomes rotationally supported outside of the black hole, an accretion shock forms and traverses the stellar envelope. Energy is carried from the central geometrically thick accretion disk to the stellar envelope by convection. Energy losses through neutrino emission and nuclear photodisintegration are calculated but do not seem important following the rapid early drop of the accretion rate following circularization. We find that the shock velocity, energy, and unbound mass are sensitive to convective efficiency, effective viscosity, and initial stellar angular momentum. Our simulations show that given the appropriate combinations of stellar and physical parameters, explosions with energies ∼5 × 1050 erg, velocities ∼3000 km s−1, and unbound material masses ≳ 6 M☉ are possible in a rapidly rotating 16 M☉ main-sequence progenitor star. Further work is needed to constrain the values of these parameters, to identify the likely outcomes in more plausible and massive LRGB progenitors, and to explore nucleosynthetic implications.
Key RFID implementation factors affecting “ sourcing ” decision of RFID systems in supply chain of manufacturing industry

The main aim of this study is to determine the key RFID implementation factors influencing ‘in-house’ or outsourcing decision of RFID system implementation decision. Using structural equation modeling (SEM) on empirical data, we examine the effects of technological factors, operational factors and regulatory factors on RFID implementation decision. The SEM analysis result reveals that variables within the construct and the construct itself have different effect on RFID system implementation. This study finds that technological factors have high influence on ‘in-house’ RFID implementation decision, and regulatory factor have high influence on out-sourcing implementation decision whereas operational factor have high influence on both implementation decision. The finding of this study provides invaluable theoretical and managerial implications, and contribute to the decision making process of managers in RFID system implementation. The study can be further extended to find out the relative importance of constructs on implementation decision.
Early detection of type 2 diabetes and atherosclerotic disease

Type 2 diabetes is mainly caused by a combination of genetic factors, unhealthy diet, physical inactivity, and obesity, and is associated with a significantly increased risk of atherosclerosis and cardiovascular death. Atherosclerosis typically takes many years to develop. It involves infiltration of lipids, inflammatory cells, smooth muscle cells and collagen in the artery wall, resulting in fibrous plaques (Figure 1). Plaque formation is closely related to ageing and most plaques do not cause symptoms. However, if the plaque further develops into a complicated lesion, it is prone to rupture and can thus cause myocardial infarction or stroke.
Implementation of Parallel Web Crawler through .NET Technology

The WWW is increasing at very fast rate and data or information present over web is changes very frequently. As the web is very dynamic, it becomes very difficult to get related and fresh information. In this paper we design and develop a program for web crawler which uses multiple HTTP for crawling the web. Here we use multiple threads for implementation of multiple HTTP connection. The whole downloading process can be reduced with the help of multiple threads. This paper deals with a system which is based on web crawler using . net technology. The proposed approach is implemented in VB.NET with multithread to crawl the web pages in parallel and crawled data is stored in central database (Sql Server). The duplicacy of record is checked through stored procedure which is pre complied & checks the result very fast. The proposed architecture is very fast and allows many crawlers to crawl the data in parallel.
Management dilemmas in innovative supplier networks

This paper focuses on the challenges in managing innovation within supply networks. We present an empirical study on innovation collaboration between a focal company and its supply network of small and medium sized enterprises. By analysing the case from the viewpoints of the focal company, the suppliers and investors we point out three controversial issues in innovation management within the supply network: intellectual property rights, partnering versus competition, and commitment versus independency. Furthermore, we analyse the suppliers' positions with a purchasing portfolio model and present implications for innovation management practices in supply chains.
A Survey On Dual-Server Public-Key Encryption With Keyword Search For Secure Cloud Storage

Searchable encryption is of expanding enthusiasm for ensuring the information protection in secure searchable distributed storage. In this work, we explore the security of an outstanding cryptographic primitive, in particular Public Key Encryption with Keyword Search (PEKS) which is exceptionally helpful in numerous utilizations of distributed storage. Shockingly, it has been demonstrated that the customary PEKS system experiences an inalienable instability called inside Keyword Guessing Attack (KGA) propelled by the malevolent server. To address this security defenselessness, we propose another PEKS structure named Dual-Server Public Key Encryption with Keyword Search (DS-PEKS). As another fundamental commitment, we characterize another variation of the Smooth Projective Hash Functions (SPHFs) alluded to as straight and homomorphism SPHF (LH-SPHF). We then demonstrate a bland development of secure DS-PEKS from LH-SPHF. To represent the possibility of our new structure, we give a proficient instantiation of the general system from a DDH-based LH-SPHF and demonstrate that it can accomplish the solid security against inside KGA.
A Robust Approach for Efficient Sodium Storage of GeS2 Hybrid Anode by Electrochemically Driven Amorphization

Sodium ion batteries (NIBs) have become attractive promising alternatives to lithium ion batteries in a broad field of future energy storage applications. The development of high‐performance anode materials has become an essential factor and a great challenge toward satisfying the requirements for NIBs, advancement. This work is the first report on GeS2 nanocomposites uniformly distributed on reduced graphene oxide (rGO) as promising anode materials for NIBs prepared via a facile hydrothermal synthesis and a unique carbo‐thermal annealing. The results show that the GeS2/rGO hybrid anode yields a high reversible specific capacity of 805 mA h g−1 beyond the theoretical capacity, an excellent rate capability of 616 mA h g−1 at 5 A g−1, and a cycle retention of 89.4% after 100 cycles. A combined ex situ characterization study reveals that the electrochemically driven amorphization plays a key role in achieving efficient sodium storage by accommodating excess sodium ions in the electrode materials. Understanding the sequential conversion‐alloying reaction mechanism for GeS2/rGO hybrid anodes provides a new approach for developing high‐performance energy storage applications.
Indonesian Modified Checklist for Autism in Toddler, Revised with Follow-Up (M-CHAT-R/F) for Autism Screening in Children at Sanglah General Hospital, Bali-Indonesia

Background: Autism Spectrum Disorder (ASD) is a developmental disorder characterized by impaired reciprocal social interaction and communication, and by a restricted, repetitive or stereotyped behavior. Early detection of autism is recommended on all toddlers from the ages of 9 months because of increasing in prevalence. The Modified Checklist for Autism (M-CHAT) in Toddlers, a Revised with Follow-Up (M-CHAT-R/F) is a 2-stage parent-report screening tool to assess a risk for ASD and it demonstrates an improvement compared to the original M-CHAT. It is translated to Indonesian language by Soetjiningsih and colleagues, and it needs to be validated. Methods: This is a diagnostic accuracy study conducted at Sanglah Hospital, Bali, conducted from March 2015 to December 2016. We included children 18-48 months in this study. The parents of the outpatient children in the growth and development clinic of Sanglah Hospital were asked to fill out the Indonesian M-CHAT-R/F form. In the same visit, the Autism Spectrum Disorder (ASD) assessment according to the DSM-5 as a gold standard was done by the researchers, without knowing the M-CHAT -R/F result. The assessment comparison based on M-CHAT-R/F and DSM-5 was analyzed to obtain the AUC intersection on ROC curve that gives the best sensitivity and specificity. Results: We found 10.71% of our outpatient was diagnosed with autism according to DSM 5, when they are 18-24 months old. The Indonesian version of M-CHAT-R/F as an ASD screening tool has 88.9% in sensitivity and 94.6% in specificity. Conclusion: Our results suggest that the Indonesian translation of the M-CHAT-R/F is an effective screening instrument for ASD, particularly when a two-step screening process is used.
Cycle XXVI MUSCULAR MODIFICATIONS IN CHRONIC SPINAL CORD INJURED PATIENTS

In this thesis muscular modifications in chronic spinal cord injured patients have been investigated. Using a translational approach, a mini-invasive muscular biopsy technique in Spinal Cord Injured patients has been validated. Moreover, the possible role of circulating levels of myostatin as a possible candidate biomarker for muscular modifications in chronic SCI patients has been evaluated. Lastly, the molecular modifications of PGE2 pathway on muscular specimens of chronic SCI patients has been studied. All material is original and based on direct Author ’s experience. RIASSUNTO In questa tesi vengono indagate le modificazioni muscolo-scheletriche in pazienti affetti da mielolesione cronica. In un’ottica traslazionale, si è affrontata la problematica in oggetto partendo dalla validazione di una metodica di prelievo bioptico mini-invasivo muscolare su paziente, alla determinazione di un possibile biomarker serico di modficazione muscolare, la miostatina. Inoltre si è iniziato a investigare il ruolo del PGE2 come possibile mediatore delle modificazioni muscolo scheletriche nei pazienti mielolesi cronici. Tutto il materiale è originale e basato sull’esperienza diretta dell’autore.
Design and Development of Oral Transmucosal Film for Delivery of Salbutamol Sulphate

The present study was aimed to develop a quick release transmucosal drug delivery system without the need of specific delivery device for the treatment of acute asthmatic attack. Oral transmucosal films were prepared by solvent casting technique using hydrophilic polymers like sodium alginate - polyvinyl alcohol (PVA)in various combinations. A 3 2 factorial design was employed to study the effect of independent variables viz concentration of sodium alginate and PVA, and its influence on dependent variable (t 80% and % moisture content). Formulation (A3) containing sodium alginate (300 mg) and PVA (150 mg) exhibited optimum performance having better dissolution profile than marketed tablet (Asthalin) releasing 99.49% drug in 7 min against 52.44%. Moreover such type of delivery system has advantages over conventional tablet by avoiding first pass metabolism of drug.
Comparisons and the Case for Interaction among Neanderthals and Early Modern Humans in the Levant

Summary. There is good reason to believe that both archaic and anatomically modern humans occupied south-west Asia at the same time. On the assumption that this was indeed the case, this paper attempts to draw comparisons between the Neanderthals and their modern contemporaries and to examine the possibilities of interaction between the two. South-west Asia is the only region in the world where two biologically distinct hominids are associated with the Middle Palaeolithic. Thus, the region provides a unique opportunity to make direct comparisons between archaic hominids, notably the Neanderthals, and early representatives of anatomically modern humans. The primary question to be dealt with here is whether these two populations, defined on the basis of their morphological characteristics, also varied with regard to their cultural and behavioral adaptations. In addition, as will be seen, there is a strong possibility that both of the groups occupied the region simultaneously rather than in an alternating fashion, and this provides the opportunity to consider the question of possible interactions between them. In order to deal with these issues it is first necessary to present a brief overview of the Levantine Middle Palaeolithic with regard to assemblage types, chronology and hominid associations.
Hydrodynamic modes of homogeneous and isotropic fluids

Relativistic fluids are Lorentz invariant, and a non-relativistic limit of such fluids leads to the well-known Navier–Stokes equation. However, for fluids moving with respect to a reference system, or in critical systems with generic dynamical exponent zz, the assumption of Lorentz invariance (or its non-relativistic version) does not hold. We are thus led to consider the most general fluid assuming only homogeneity and isotropy and study its hydrodynamics and transport behaviour. Remarkably, such systems have not been treated in full generality in the literature so far. Here we study these equations at the linearized level. We find new expressions for the speed of sound, corrections to the Navier–Stokes equation and determine all dissipative and non-dissipative first order transport coefficients. Dispersion relations for the sound, shear and diffusion modes are determined to second order in momenta. In the presence of a scaling symmetry with dynamical exponent zz, we show that the sound attenuation constant depends on both shear viscosity and thermal conductivity.
Which gloves are efficient to protect against titanium dioxide nanoparticles in work conditions

Recent articles underline the potential health risks associated to the “nano” revolution. Titanium dioxide nanoparticles (nTiO2) are one of these engineered nanoparticles (ENP) that have been cautioned about their likely harmful effects on health. In occupational use, to handle ENP, many Health & Safety agencies have recommended the application of the precautionary principle namely the recommendation of the use of protective gloves against chemicals. However, at the best of our knowledge, no study about the penetration of ENP through protective gloves in working conditions was performed. This study was designed to evaluate the efficiency of several models of protective gloves against nTiO2. Two types of nitrile rubber gloves (100 μm and 200μm), latex and butyl rubber gloves were brought into contact with nTiO2 in water, in propylene glycol (PG) or in powder. Mechanical biaxial deformations (BD), simulating the flexing of the hand, were applied to the samples during their exposure to ENP. Depending the model of gloves and the mode of application of the NP, the results obtained by ICP-MS (Inductively Coupled Plasma – Mass Spectrometry) are different. For nTiO2 in water, the passage is highlighted for nitrile rubber gloves (100 μm) after only 60 deformations and the nTiO2 concentration reaches its maximum for 180 DB. Regarding the nTiO2 in powder, nitrile rubber gloves (100 μm) and butyl rubber, the values achieved are significant but less than the solutions.
A NEW MODEL FOR COMPLEX DYNAMICS IN A DC GLOW DISCHARGE TUBE

Based on a detailed experimental characterization of the complex dynamics of a Ne discharge tube, a new phenomenological model governed by four differential equations is proposed. Such a model takes into account the competition between a nonlinear relaxation oscillator related with external electronic features and a forced harmonic oscillator accounting for the plasma eigenfrequency. From their interaction the quasi periodicity route to chaos emerges as confirmed by the experimental observations. In the control parameter space, stability diagrams for periodic oscillations of arbitrary period are computed using the isospike technique and compared with standard diagrams of Lyapunov exponents. Such diagrams reveal complex patterns of stability phases with extended regions of multistabilty.
Innovative Treatments in Diabetes Type 1

Type 1 diabetes mellitus (T1DM) is a metabolic disease caused by autoimmune destruction of beta cells in the pancreas leading to insufficient production of insulin. The standard treatment of diabetes relies on multiple injections of insulin. One of the main drawbacks of this treatment is the inability to replicate timing and action on endogenous insulin secretion when beta cells are intact. Resulting hyper- and hypoglycemias cause long term and acute side effects of the disease. There are multiple approaches to overcome this problem: insulin pumps, oral insulin preparations, immunomodulatory treatments and transplantation of beta cells. This review summarizes recent advances in the treatment of diabetes.
Marketing Activity of the Hungarian SMEs Working in the Food Processing Industry

We are looking for the answer whether what tendencies were indicative of the future development of required marketing activity of the SMEs in the article dealing with marketing activity of the SMEs working in the food industry. The article based on a nationwide survey among 200 SMEs working in the food processing industry. In this article we focus on the SMEs working in the dairy and meat processing industries. The results of the nationwide research and some domestic references refer to that there is a latent demand on effective marketing activity among small and medium sized enterprises. It manifests itself in specifying marketing related fields to be improved in the future. The marketing itself is believed not to be an important field at the same time. This apparent opposition is the small enterprise marketing paradox in which background is the lack of knowledge about the marketing instruments. It can be stated that these small businesses collect mainly general market information and have no information about particular products. Therefore the presence of marketing planning is really rare and where there is some kind of planning it is not connected to available founds and follow-up control. The marketing strategy can be characterized by products processed mainly at low or medium level. Therefore the market position is defined by “lower pricegood quality”. They mainly use the traditional distribution channels and their communication is accidental and has a low level. The marketing oriented way of thinking is still exists among the factors affecting on entrepreneurial behaviour which can not be found on the level of clusters according to our results. We could identify 8,3% of the enterprises as having satisfactory marketing activity.
1 Hz FLARING IN THE ACCRETING MILLISECOND PULSAR NGC 6440 X-2: DISK TRAPPING AND ACCRETION CYCLES

The dynamics of the plasma in the inner regions of an accretion disk around accreting millisecond X-ray pulsars (AMXPs) is controlled by the magnetic field of the neutron star. The interaction between an accretion disk and a strong magnetic field is not well understood, particularly at low accretion rates (the so-called propeller regime). This is due in part to the lack of clear observational diagnostics to constrain the physics of the disk–field interaction. Here, we associate the strong ∼1 Hz modulation seen in the AMXP NGC 6440 X-2 with an instability that arises when the inner edge of the accretion disk is close to the corotation radius (where the stellar rotation rate matches the Keplerian speed in the disk). A similar modulation has previously been observed in another AMXP (SAX J1808.4−3658) and we suggest that the two phenomena are related and that this may be a common phenomenon among other magnetized systems. Detailed comparisons with theoretical models suggest that when the instability is observed, the interaction region between the disk and the field is very narrow—of the order of 1 km. Modeling further suggests that there is a transition region (∼1–10 km) around the corotation radius where the disk–field torque changes sign from spin-up to spin-down. This is the first time that a direct observational constraint has been placed on the width of the disk–magnetosphere interaction region, in the frame of the trapped-disk instability model.