Miracle-dz/UniFAR-FTUs huggingface dataset:
A Topology and Design Optimization Method for Wideband Piezoelectric Wind Energy Harvesters

This paper presents a topology for wideband piezoelectric wind energy harvesting and a design optimization method for capturing maximum available energy considering the wind speed distribution model. The proposed device is useful for powering of wireless sensor nodes in smart monitoring applications. The device includes a piezoelectric beam that vibrates due to the interactions between miniaturized permanent magnets (PMs) embedded in a small turbine and a magnet at the tip of the beam. The design method determines the resonance frequency of the beam with respect to the wind speed distribution model. Compared to the conventional wideband topologies that include multiple beams for resonating at different frequencies, the suggested topology uses a single beam and achieves the wideband feature via the arrangement of PMs within the turbine. This feature enhances the power density of the piezoelectric wind energy harvester. The wideband feature of the device is experimentally verified using a device prototype in which the beam resonance occurs at the fan rotational speeds of 155.0, 193.5, 257.9, and 387.0 rad/s. The maximum power density, maximum efficiency, and cut-in wind speed of the device are 0.59 mW/cm3, 24%, and 2.1 m/s, respectively.
ENFOQUE ESTADÍSTICO DE ANÁLISIS DE TEXTURA: SU APLICACIÓN A LA CLASIFICACIÓN DE UN ORTOFOTOMOSAICO DEL VALLE DE INUNDACIÓN DEL ARROYO NAPOSTA GRANDE

El objetivo de este trabajo es evaluar la aplicacion del enfoque estadistico de analisis de texturas a la clasificacion de fotografias aereas de escala grande. Este enfoque se basa en el calculo de medidas estadisticas que incorporan la relacion espacial entre pixeles y permiten generar bandas de textura. En el estudio se utilizo un ortofotomosaico correspondiente al valle del arroyo Naposta Grande, en la ciudad de Bahia Blanca, Argentina. Se procedio a la clasificacion supervisada del ortofotomosaico utilizando tanto la informacion espectral como la informacion espacial proporcionada por las bandas de textura. Se calculo la matriz de correlacion entre las distintas bandas para establecer la mejor combinacion que optimizara la clasificacion y se evaluaron los resultados mediante las matrices de confusion. La metodologia utilizada contribuyo a mejorar notablemente la clasificacion del ortofotomosaico basada unicamente en la informacion espectral.
Biostatistics in nonclinical and preclinical drug development

Compared to biostatistics in clinical drug development, much less papers were published in the area of nonclinical and preclinical drug development. There seem to be several reasons for this. First, the “preclinical” and “nonclinical” are contain a wide range of topics. These include, but are not limited to, the candidate drug search process, toxicology and pharmacological studies, drug stability assays, and bioassays. This broad range of subjects causes the definition of this area of statistics to be much vaguer than that for the phase I – IV clinical trials in drug development. Second, due to the interest of the regulators, most notably in the clinical area, the statistical approaches tend to be more standardized. Refer, for example, the detailed description on baseline adjustments in the “CPMP points-to-consider” by Grouin and Lewis (2004). In the nonclinical area only a few statistics-related guidance documents can be found, for example for carcinogenicity studies in toxicology (anonymous, 2001). The number of staff in statistics dedicated to the respective areas was described as directly related to the number of guidelines (Lendrem, 2002). Thus, as a third effect, clinical topics are dominating at international biostatistics conferences. Fourth, in the clinical area is an external pressure for objectivity and correctness, and therefore eventually for statistical presence; because a mistaken decision in nonclinical research does mainly harm the pharmaceutical company, whereas a mistaken decision in clinical development may harm the public primarily. On April 22 – 23, 2004, the 4th International DIA workshop on statistical methodology in nonclinical research and development took place in Dublin, Ireland. A total of 20 presentations were given in five sessions: statistics for genomics, in vitro pharmacology, statistics for QSAR, advanced modeling in pharmacology, and statistics of quantitative assays. In this special issue of Biometrical Journal, two of the contributions
Current concepts in platelet transfusion

This is the era of component therapy. Therefore there is a need for rational use of platelet concentrate. Lot of knowledge has been added recently in the field of platelet specially about the platelet rich plasma and its application in clinical practice. The current review focuses on improvement in preparation of platelet rich plasma, the procedure to make the same more safe and its rational use. Furthermore newer aspects of platelet concentrate use in surgical practice and for regenerative medicine has also been discussed. It also covers some progress and hurdles in preparation of platelet substitutes.
Edoxaban for reducing the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation

Introduction: Oral anticoagulation is central to the management of patients with atrial fibrillation (AF) and at least one additional stroke risk factor. For decades, the vitamin K antagonists (e.g. warfarin) remained the only oral anticoagulant available for stroke prevention in AF. The non-vitamin K oral anticoagulants (NOACs) are now available, and these drugs include the direct thrombin inhibitors and factor Xa inhibitors. The latter class includes edoxaban, which has recently been approved for stroke prevention in AF by the United States Food and Drug Administration and the European Medicine Agency. In line with other NOACs, edoxaban avoids the many limitations of warfarin associated with variability of anticoagulation effect and multiple food and drug interactions. Areas covered: In this review, the currently available evidence on edoxaban in patients with non-valvular AF is discussed. The pharmacology, efficacy and safety, and current aspects of use of edoxaban in patients with non-valvular AF for stroke and thromboembolism prevention are reviewed. Expert opinion: Phase III trials on edoxaban for stroke prevention in non-valvular AF confirms non-inferiority of edoxaban compared to well-managed warfarin both in terms of efficacy and safety. Currently ongoing and future trials as well as real-world data are warranted to confirm its effectiveness and safety for chronic anticoagulation and improve evidence in other areas which are lacking evidence where NOAC use remains controversial.
Vietnamese sentence recognition algorithm in embedded device based on specialized transition network

In this work, a proposed high speed continuous speech recognition algorithm which was designed towards embedded devices and experimented on Vietnamese will be presented. To be more specific, this algorithm has used a transition network (TN) as search-space, which integrates many language model systems and condensed by the algorithm format to both reduce processing time and memory usage while matching. The final results which were evaluated on 100 speech samples have achieved the high accuracy of 92.24% on an embedded device named WandBoard Rev C1 kit.
Selective inhibition of miR‐92 in hippocampal neurons alters contextual fear memory

Post‐transcriptional gene regulation mediated by microRNAs (miRNAs) is implicated in memory formation; however, the function of miR‐92 in this regulation is uncharacterized. The present study shows that training mice in contextual fear conditioning produces a transient increase in miR‐92 levels in the hippocampus and decreases several miR‐92 gene targets, including: (i) the neuronal Cl‐ extruding K+Cl‐ co‐transporter 2 (KCC2) protein; (ii) the cytoplasmic polyadenylation protein (CPEB3), an RNA‐binding protein regulator of protein synthesis in neurons; and (iii) the transcription factor myocyte enhancer factor 2D (MEF2D), one of the MEF2 genes which negatively regulates memory‐induced structural plasticity. Selective inhibition of endogenous miR‐92 in CA1 hippocampal neurons, by a sponge lentiviral vector expressing multiple sequences imperfectly complementary to mature miR‐92 under the control of the neuronal specific synapsin promoter, leads to up‐regulation of KCC2, CPEB3 and MEF2D, impairs contextual fear conditioning, and prevents a memory‐induced increase in the spine density. Taken together, the results indicate that neuronal‐expressed miR‐92 is an endogenous fine regulator of contextual fear memory in mice. © 2014 Wiley Periodicals, Inc.
Spread of Influenza

Despite rapid advances in the knowledge of the properties and behaviour of influenza viruses in the laboratory, most of the major epidemiological problems of influenza remain unsolved. There are three problems which constantly trouble the minds of all epidemiologists concerned with influenza. First, is there a true spread of virus from one country to another, or is there merely an apparent spread due to successive activation of endemic virus in different countries ? Secondly, how does the influenza virus survive in nature in the long interepidemic periods ? Thirdly, what factors are responsible for the sudden storm of influenza which arises from an apparently calm sea, and which may do as little damage as it did in 1950-1 or as much as it did in 1918-19 ? During the 1948-9 and 1950-1 epidemics, workers in W.H. O. influenza laboratories have attempted to isolate influenza viruses which they have sent to the World Influenza Centre in London for typing. It was hoped that following an investigation of this kind answers would be forthcoming to at least some of the epidemiological problems of influenza, and that at the same time information required in the preparation of influenza vaccines would become available. In the present paper influenza epidemiology is discussed in the light of experiences of the 1950-1 influenza epidemic. No attempt has -been made to describe the investigations in detail in this account; a report which is being prepared for the Bulletin of the World Health Organization will include these details. We hope to acknowledge in that report the kind help of individual workers in many W.H. O. influenza centres. Without their co-operation this work would not have been possible.
A Low-Voltage Ride-Through Technique for Grid-Connected Converters With Reduced Power Transistors Stress

With more and more distributed energy resources being installed in the utility grid, grid operators start imposing the low-voltage ride-through requirement on such systems to remain grid-connected and inject reactive and/or active current to support grid voltage during fault conditions. This paper proposes a positive and negative sequence current injection method to meet such requirement. In the meantime, the proposed method can reduce the second harmonic ripples in the dc link of the power converter without violating the peak current constraint of the power transistors. The long-term reliability of the converter system can thus be improved.
Comparaison des ichtyofaunes estuariennes du Sénégal, de Gambie et de Guinée

INTRODUCTION Une etude pluridisciplinaire des mangroves de la zone des Rivieres du Sud se doit d’evoquer, au chapitre ecologie, l’importance de la faune aquatique et particulierement de sa composante ichtyologique. Le domaine aquatique des Rivieres du Sud incluant la frange cotiere, les chenaux, les plaines inondables et les estuaires, nous ne traiterons ici que de ce dernier milieu. Les estuaires sont definis au sens large comme des « indentations de la cote en contact restreint avec l’ocean.
Modeling and prototype of a dynamic wireless charging system using LSPS compensation topology

The proposed paper presents the construction process of a high efficient and high-immune misalignment tolerant loosely coupled inductive power transfer (LCIPT) system using dynamic wireless power transfer (WPT) concept to charge a 48 V battery bank at 500 W through 16 cm air-gap. The purpose of this work is to investigate the influence of a third coil functioning as a transmitter coil. The resonant circuit as well as the electronic power converters used to implement a prototype are deeply explained.
Keratohyalin: Extraction and in vitro Aggregation

Kercatohyalin can be extracted from epidermis by 1.0 molar phosphate buffer (pH 7.0), as demonstrated histochemically and ultrastructurally. If the extracted material is dialyzed against water, it aggregates to form granules that are similar to keratolhyalin granules in size, shape, histochemical staining, and electron opacity.
Ka-Band Cavity-Backed Detached Crossed Dipoles for Circular Polarization

An implementation of circularly polarized crossed dipoles in millimeter-wave band is presented in this paper. Novel detached crossed dipoles have been designed to tackle the problems confronted by single-fed crossed dipoles in mm-wave band. An evolution procedure from conventional crossed dipoles to the proposed ones is given. Meanwhile, a metallic ridge is added in the cavity to provide a robust feeding structure. Measurements of an optimized antenna prototype show that it can achieve a bandwidth from 27 to 36.8 GHz for both AR ≤ 3 dB and |S11| ≤ -10 dB and an average broadside gain of 12.4 dBi. The measured results agree reasonably well with simulations. For reference to practical designs, studies on five critical parameters have also been performed in this paper.
Occurrence rate and clinical predictors of hypertensive pseudocrisis in emergency room care.

OBJECTIVES To describe the prevalence of hypertensive pseudocrisis in patients treated in emergency rooms with substantially elevated blood pressure levels. To compare this prevalence in private and public hospitals. To describe the frequency of wrong treatment for this condition. To identify, during triage, independent predictors of pseudocrisis. To evaluate the prognosis of patients with pseudocrisis. METHODS Patients above the age of 18, admitted to the Emergency Rooms of two hospitals (private and public) during a 6 month timeframe, with diastolic blood pressure > or = 120 mmHg were included in the study. Hypertensive pseudocrisis was determined when none of the criteria for hypertensive crisis were present (Guidelines of the Brazilian Society of Cardiology(1)). RESULTS In the 110 patients studied, the prevalence of hypertensive pseudocrisis was 48% (95% CI = 39%-58%) and prevailed in the private hospital (59% vs 37%, p=0.02). The frequency of wrong treatment was similar between the two hospitals (94% vs 95%, p=0.87). After multivariate analysis, the presence of headache upon admission (Odds Ratio=5.4; 95% CI = 5.1-13; p< 0.001) and diastolic BP levels (Odds Ratio=0.93; 95% CI = 0.89-0.97; p=0.002) were independent predictors of pseudocrisis. The 5 month mortality rate was lower in the pseudocrisis group than the hypertensive crisis group (0% vs 21%, p=0.0004). CONCLUSIONS There is a high prevalence of hypertensive pseudocrisis in patients when hypertensive crisis is suspected, particularly in the private hospital. The frequency of wrong treatment was similar for both the private and public hospitals. Headaches and diastolic BP levels are independent predictors for this clinical condition. Hypertensive pseudocrisis has a low rate of lethality.
Nutritional And Functional Properties of Cynara Crops (Globe Artichoke and Cardoon) and Their Potential Applications: A Review

Cynara genus, originating from the Mediterranean area, includes globe artichoke (Cynara cardunculus var. scolymus L) and cardoon (Cynara cardunculus var. altilis DC). Traditionally these crops have long been used as food and medicine. Nowadays, they are considered as functional foods, owing to their nutritional properties. Artichoke has exhibited hepatoprotective and antioxidative activities, as well as the ability to inhibit cholesterol biosynthesis and low density lipoprotein oxidation, due to its high content of polyphenolic compounds. Moreover, the edible and agro-industrial by-products of artichoke are rich sources of inulin. In addition, cardoon, having similar bioactive compounds, offers a wide spectrum of different uses: for medicinal purposes, as rennet substitute for the preparation of high quality traditional cheese, as oil suitable for human consumption, as biofuel or for paper production. Also, these plants can be used in ruminant nutrition as green forage or preserved as silage, with high organic matter digestibility.
[Role of CFH and ARMS2 polymorphisms in retinopathy and coronary artery disease in type 1 diabetes].

BACKGROUND Type 1 diabetes is associated with vascular morbidity. The aim of this study was to evaluate the role of polymorphisms rs1410996 CFH and rs10490924 ARMS2 with proliferative diabetic retinopathy and coronary disease in type 1 diabetes patients. MATERIAL AND METHODS We present a retrospective study that analyses the clinical characteristics and the polymorphisms rs1410996 CFH and rs10490924 ARMS2 of 147 type 1 diabetes patients. RESULTS The patients who developed proliferative diabetic retinopathy in the first 20 years carried the rs1410996 CFH polymorphism. The overall risk-allele frequency was significantly higher among patients with coronary artery disease than in those without it (75 vs. 53%, p<0.001). CONCLUSIONS rs1410996 CFH polymorphism could be associated with both proliferative diabetic retinopathy and coronary artery disease in type 1 diabetes patients. However, rs10490924 ARMS2 does not seem to be associated either with retinopathy or coronary artery disease.
Testing the Hypothesis That a Clade Has Adaptively Radiated: Iguanid Lizard Clades as a Case Study

The study of adaptive radiations has played a fundamental role in understanding mechanisms of evolution. A recent resurgence in the study of adaptive radiations highlights a gap in our knowledge about determining whether a clade constitutes adaptive diversification. Specifically, no objective criteria exist to judge whether a clade constitutes an adaptive radiation. Most clades, given enough time, will diversify adaptively to some extent; therefore, we argue that the term “adaptive radiation” should be reserved for those clades that are exceptionally diverse in terms of the range of habitats occupied and attendant morphological adaptations. Making such a definition operational, however, requires a comparative analysis of many clades. Only by comparing clades can one distinguish those that are exceptionally diverse (or nondiverse) from those exhibiting a normal degree of adaptive disparity. We propose such a test, focusing on disparity in the ecological morphology of monophyletic groups within the lizard family Iguanidae. We find that two clades, the Polychrotinae and Phrynosomatinae, are exceptionally diverse and that two others, the Crotaphytinae and Oplurinae, are exceptionally nondiverse. Potential explanations for differences in diversity are discussed, as are caveats and future extensions of our approach.
Finding Similar Nucleotide Sequences Using Network BLAST Searches

The Basic Local Alignment Search Tool (BLAST) is the first tool in the annotation of nucleotide or amino acid sequences. BLAST is a flagship of bioinformatics due to its performance and user‐friendliness. Beginners and intermediate users will learn how to design and submit blastn and Megablast searches on the Web pages at the National Center for Biotechnology Information. We map nucleic acid sequences to genomes, find identical or similar mRNAs, expressed sequence tag, and noncoding RNA sequences, and run Megablast searches, which are much faster than blastn. Understanding results is assisted by taxonomy reports, genomic views, and multiple alignments. We interpret expected frequency thresholds, biological significance, and statistical significance. Weak hits provide no evidence, but indicate hints for further analyses. We find genes that may code for homologous proteins by translated BLAST. We reduce false positives by filtering out low‐complexity regions. Parsed BLAST results can be integrated into analysis pipelines. Links in the output connect to Entrez and PubMed, as well as structural, sequence, interaction, and expression databases. This facilitates integration with a wide spectrum of biological knowledge. © 2017 by John Wiley & Sons, Inc.
Cells Antigen Cross-Presentation in Dendritic Molecular Mechanisms of TLR2-Mediated

Cross-presentation is a key function of dendritic cells (DCs), which present exogenous Ags on MHC class I molecules to prime CTL responses. The effects of TLR triggering on the cross-presentation of exogenous Ags by DCs remain unclear. In this study, we used synthetic dipalmitoylated peptides and TLR2 agonist–conjugated peptides as models to elucidate the mechanisms of TLR2-mediated cross-presentation. We observed that the internalization of dipalmitoylated peptides by bone marrow–derived DCs was facilitated by TLR2 via clathrin-mediated endocytosis. The administration of these dipalmitoylated peptide-pulsed bone marrow–derived DCs eliminated established tumors through TLR2 signaling. We further demonstrated that the induction of Ag-speciﬁc CTL responses and tumor regression by dipalmitoylated peptides was TAP independent. In addition, presentation of dipalmitoylated peptides by MHC class I molecules was blocked in the presence of an endosomal acidiﬁcation inhibitor (chloro-quine) or a lysosomal degradation inhibitor (Z-FL-COCHO). The endocytosed dipalmitoylated peptide also passed rapidly from early endosome Ag-1–positive endosomes to RAS-related GTP-binding protein 7 (Rab7)–associated late endosomes compared with their nonlipidated counterparts. Furthermore, we found that dipalmitoylated peptide–upregulated Rab7 expression corre-lated with Ag presentation via the TLR2/MyD88 pathway. Both JNK and ERK signaling pathways are required for upregulation of Rab7. In summary, our data suggest that TLR2-mediated cross-presentation occurs through the upregulation of Rab7 and a TAP-independent therapeutic effect of peptide immunization, TC-1 tumor-bearing mice were immunized s.c. with PBS or 10 m g IDG or Pam2IDG in PBS on days 7 and 14. To investigate peptide cross-presentation by BMDCs, TC-1 tumor-bearing mice were immunized i.v. with PBS, BMDCs, or IDG- or Pam2IDG-pulsed BMDCs on day 7. The local tumor diameter was measured with calipers and monitored three times per week until 33–45 d. The tumor volume was calculated by the following formula: length 3 width 3 width/2.