Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence for Tethering of Human Cytomegalovirus Genomes to Host Chromosomes

Tethering of viral genomes to host chromosomes has been recognized in a variety of DNA and RNA viruses. It can occur during both the productive cycle and latent infection and may impact viral genomes in manifold ways including their protection, localization, transcription, replication, integration, and segregation. Tethering is typically accomplished by dedicated viral proteins that simultaneously associate with both the viral genome and cellular chromatin via nucleic acid, histone and/or non-histone protein interactions. Some of the most prominent tethering proteins have been identified in DNA viruses establishing sustained latent infections, including members of the papillomaviruses and herpesviruses. Herpesvirus particles have linear genomes that circularize in infected cell nuclei and usually persist as extrachromosomal episomes. In several γ-herpesviruses, tethering facilitates the nuclear retention and faithful segregation of viral episomes during cell division, thus contributing to persistence of these viruses in the absence of infectious particle production. However, it has not been studied whether the genomes of human Cytomegalovirus (hCMV), the prototypical β-herpesvirus, are tethered to host chromosomes. Here we provide evidence by fluorescence in situ hybridization that hCMV genomes associate with the surface of human mitotic chromosomes following infection of both non-permissive myeloid and permissive fibroblast cells. This chromosome association occurs at lower frequency in the absence of the immediate-early 1 (IE1) proteins, which bind to histones and have been implicated in the maintenance of hCMV episomes. Our findings point to a mechanism of hCMV genome maintenance through mitosis and suggest a supporting but non-essential role of IE1 in this process.
Liquid crystallinity and thermal properties of polyhedral oligomeric silsesquioxane/side-chain azobenzene hybrid copolymer

Abstract Acrylic acid-modified polyhedral oligomeric silsesquioxane (AC-POSS) was synthesized by the reaction between the amine groups in polyhedral oligomeric silsesquioxane (POSS) and acrylic acid, which could dissolve in water and can be easily purified. Free-radical copolymerization was applied to synthesize azobenzene liquid crystalline polymer silsesquioxane (LCP-POSS) with different proportions of AC-POSS and liquid crystalline monomers. The trans-isomers of azobenzene moieties in LCP-POSS were gradually transformed to cis-isomers with increasing ultraviolet irradiation time. The photoisomerization reaction of liquid crystalline polymer (LCP) and LCP-POSS showed the first-order dynamic reaction. Compared with the LCP, the photoisomerization rate constant of LCP-POSS was decreased due to the space steric hindrance of the POSS as a rigid segment. The phase transition temperature of liquid crystalline in LCP-POSS increased with increasing POSS content, and the liquid crystalline texture in LCP-POSS became smaller under the polarized light. With further increasing the POSS content (>50 wt%) in LCP-POSS, the ordered structure of the liquid crystalline phase was gradually affected, resulting in one-way liquid crystal (LC) phase behavior. The synthesized LCP-POSS has LC properties, light-responsive properties, and thermal stability. When the POSS is introduced into the LC material, the phase state of the LC material will become more abundant and the LC phase will become more stable. The significance of this study is to develop and extend its applications as stimuli-responsive materials and devices.
Looking at Aesthetic Emotions in Advertising Research Through a Psychophysiological Perspective

Do usual commercials elicit the full spectrum of emotions? For this perspective paper, we posit that they do not. Concepts and measures related to the adaptive functions and well-being areas of emotion research cannot simply be transferred for use in advertising research. When a commercial elicits emotions, the emotions staged in the commercial must not be directly associated with the emotions felt by consumers when exposed to those commercials. This is why “aesthetic” emotions seem more appropriate than “utilitarian” emotions in advertising research, with the former generally felt more significantly than they are acted upon. Aesthetic emotions elicit limited physiological change, and they rely on the intrinsic pleasantness appraisal of commercials. Accordingly, pleasure and displeasure—as observed through expressive and subjective components of aesthetic emotion—often form the first and only step of commercial appraisal, and they are directed toward attitude formation rather than overt behaviors. Our preliminary psychophysiological study shows this by investigating the contributions of psychophysiological and self-reported measures of aesthetic emotions induced by commercials to explain attitudes toward advertisements. The results show that only two components of aesthetic emotion positively influenced attitudes toward the advertisements: expressive (measured by facial electromyography) and subjective (measured by the self-assessment manikin scale). Also, the subjective component of aesthetic emotion partially mediates the effects of the expressive components on attitudes toward the ads. Our exploratory study illustrates the relevance of focusing on aesthetic emotions in advertising research. It also shed new light on the contributions of the physiological, expressive, and subjective feelings components of aesthetic emotions in advertising effectiveness.
An Actual Natural Setting Improves Mood Better Than Its Virtual Counterpart: A Meta-Analysis of Experimental Data

Accumulating evidence indicates that simulated natural settings can engage mechanisms that promote health. Simulations offer alternatives to actual natural settings for populations unable to travel outdoors safely; however, few studies have contrasted the effects of simulations of natural settings to their actual outdoor counterparts. We compared the impacts of simulated and actual natural settings on positive and negative affect (mood) levels using a pooled sample of participants enrolled in extant experimental studies. Relevant articles were identified from a review of research published/in press by March 2020 and updated during the peer review of the current study. Of 16 articles identified, 6 met the inclusion criteria and administered a single cross-cutting, standardized instrument [the Positive and Negative Affect Schedule (PANAS)] before and after exposure. Random effects meta-analysis of pooled effects showed that positive affect increased in the actual settings but not in their simulated counterparts (Hedge's g = 0.87; 95% CI, 0.54, 1.20). We observed little difference in effects on negative affect change scores (g = −0.28; 95% CI, −0.62, 0.06), with studies generally showing reductions in negative affect in both settings. Further research with additional populations, settings, antecedent conditions, and durations would provide a more robust understanding of differences in effects between these two ways to enhance mood by viewing nature.
Motion Response and Energy Conversion Performance of a Heaving Point Absorber Wave Energy Converter

The heaving wave energy converter (WEC) is one typical type of point absorber WECs with high energy conversion efficiency but significantly affected by the viscous effect. It is widely known that the bottom shape of such WECs plays an important role in influencing the viscosity, so a detailed qualitative investigation is essential. Here a numerical study is performed for the influence of bottom shape on motion response and energy conversion performance of a heaving WEC. The numerical model is developed based on the potential flow theory with a viscous correction in the frequency domain. Cylindrical WECs with flat, cone, and hemispherical bottoms and the same displacement are considered. WECs with larger diameter-to-draft ratios (DDRs) are found to experience a relatively smaller viscous effect and achieve effective energy conversion in a broader frequency range. With the same DDR, the flat bottom has the most considerable viscous effect, following by the cone bottom with conical angles 90° and the hemispherical bottom. When the DDR is relatively small, the hemispherical bottom had the best energy conversion performance. Similarly, when the DDR is relatively large, the energy conversion performance of the floater with a hemispherical bottom and a cone bottom with 90° is better, while that with the flat bottom is the worst.
How American Mineralogist and the Mineralogical Society of America influenced a career in mineralogy, petrology, and plate pushing, and thoughts on mineralogy’s future role

Abstract My geologic research began at Carleton College. I studied heavy minerals in some midcontinent orthoquartzites, publishing my very first paper in American Mineralogist in 1954. As a master’s candidate at the University of Minnesota, I investigated igneous differentiation in a diabase-granophyre sill of the Duluth Gabbro Complex. Later, in a Ph.D. program at Johns Hopkins University, I became Joe Boyd’s apprentice at the Geophysical Laboratory (GL), and for a time was phase-equilibrium god of the Na-amphiboles. Doctoral research earned me an offer of a UCLA assistant professorship as a mineralogist in 1960. There, I continued pursuing amphibole P-T stability relations in lab and field. My glaucophane phase equilibrium research would later be found to have instead crystallized Na-magnesiorichterite. However, amphibole research led me to map field occurrences of HP-LT (high P-low T) blueschists of the Franciscan Complex. Thus, when plate tectonics emerged in the late 1960s, I was deep in the subduction zone. My recent studies focused on the petrology and geochemistry of oceanic crustal rocks, Californian calc-alkaline arcs, and coesite ± microdiamond-bearing crustal margin rocks in various parts of Eurasia. Other works treated global mineral resources and population, mineralogy and human health, and early Earth petrotectonic evolution. I tried to work on important problems, but mainly studied topics that fired my interest. For the future, I see the existential challenge facing humanity and the biosphere as the imperative to stop our overdrafting of mineral resources. This will require reaching a dynamic equilibrium between the use and replenishment of near-surface resources (i.e., nutrients) essential for life. Earth scientists are planetary stewards, so we must lead the way forward in life-supporting mineral usage, recycling, substitution, and dematerialization. In any event, sustainable development will soon return to the Earth’s Critical Zone of life because Mother Nature—the ruling terrestrial economist—abhors long-term overdrafting of resources Recently, a series of profound calamities have overwhelmed the World—the coronavirus pandemic, disruption of the global economy, and near-universal condemnation of the widespread, systemic abrogation of human rights/racial justice. Comparable challenges have emerged episodically ever since the rise of civilization. Such problems have been addressed over the millennia with varying degrees of success. However, human efforts have never achieved dynamic environmental equilibrium between consumption of Earth resources and rates of recharge. Sustainable development remains our long-term, existential threat.
Disturbances of extracellular protein metabolism in ceruleininduced pancreatitis

Abstract Chronic pancreatitis (CP) is still a serious clinical problem due to the significant difficulties in its diagnosis, especially in the initial stages of development. Among the mechanisms that mediate the pathogenesis of CP and lead to pancreatitis-related disorders is unregulated activation of proteolytic enzymes, namely, matrix metalloproteinases (MMPs). The aim of our study was to determine the disturbances of protein metabolism under the conditions of CP alone or in combination with diabetes type 1 (CP+DT1). Herein, CP was induced in the nonlinear male rats by intraperitoneal injection of cerulein (5 µg·kg−1 of body weight; five times during fives day). DT1 was modeled in the rats with CP by a single intraperitoneal injection of streptozotocin (65 mg·kg−1 of the body weight). The levels of MMP-2 and -9 were determined by enzyme-linked immune sorbent assay, and the level of low and middle molecular weight (LMMW) substance was measured spectrophotometrically, while the peptide fractions were analyzed by size exclusion chromatography. The present study revealed a significant increase of MMP-2 and MMP-9 levels in the serum, liver and pancreas of the rats with CP and CP+DT1. Elevated levels of MMPS may act as a factor for the initiation of subsequent cascade of events resulting in the development of pancreatitis-associated complications. Pathogenesis of chronic pancreatitis alone or in combination with diabetes type 1 has been accompanied by the formation and accumulation of LMMW substance, changes in peptide composition and level of individual peptides in the tissues of the rats. Such alterations are among key triggers of amplification of metabolic disorders under chronic pancreatitis.
4. Quality of Poultry Meat from Native Chicken Breeds – A Review

Abstract The objective of the paper was to demonstrate the possibilities of using Polish native breeds of chickens for the production of meat for its specific quality features in the light of worldwide researches. The object of the analysis was the quality of meat from slow-growing chickens raised in varied housing systems, including capons and poulards. The findings of studies on the quality of poultry meat from native breeds obtained from post-production cockerels and from hens in their post egg-laying stage have shown that there are chances for their use in meat production. Native breed hens can also be used as foundation material for the production of capons, poulards or international mixed breeds for purposes of extensive farming. The body weight of native breed hens, including their muscle build depend on the bird’s genotype, feeding, length of exploitation and farming system. Meat from native breed hens, raised in free-range systems has less fat, but with higher polyunsaturated fatty acids in their meat muscles as well as a healthier ratio of n-6/n-3 PUFA acids. Outdoor free-range access influences the meat colour, i.e., bright coloured breast muscle (L*) as well as increased intensity of red coloration of leg muscles (b*). Caponisation of hens enhances intensified body weight gains along with increased fattening of meat. In comparison with cockerel meat, the meat of capons is more juicy, tender and of better taste, while poulard meat has distinctively favourable sensory values in comparison with broiler chicken meat.
Biological characteristics of serangium japonicum and its morphology in comparion with delphastus catalinae

 Serangium japonicum Chapin and Delphastus catalinae Horn are important natural enemies of Bemisia tabaci . The biological characteristics of S. japonicum including life history, feeding behaviour, pupation, mating, oviposition, longevity of adults and the comparative morphology of the two kinds of coccinellids were studied. The results were as follows: S. japonicum developed 6-7 generations a year in Fujian Province and it overwintered in the form of adult; developmental times for eggs, 1st, 2nd, 3rd, 4th instars, prepupae and pupae were 5.23, 2.40, 1.98, 1.90, 1.75, 2.96, 5.18 days respectively, with an average of 21.5 d from oviposition to adult emergence for a generation, ranging from 19.5 to 24.5 d; survival rate of a generation was 68%; longevity of adults of S. japonicum was (63.6±21.0) d (n=10) for females and (51.6±11.7) d (n=10) for males; a female laid 75-257 eggs, averaging (136.8±57.8) eggs (n=10); male adults could tolerate starving for the period longer than female adults, but both couldn′t survive until 108 h.
Metabotropic glutamate receptor 1 in human malignancies

OF DISSERTATION . ii ACKNOWLEDGEMENT . iv DEDICATION . v TABLE OF CONTENTS . vi LIST OF TABLES . ix LIST OF FIGURES . x LIST OF SUPPLEMENTAL FIGURES . xi CHAPTER 1: AN INTRODUCTION TO METABOTROPIC GLUTAMATE RECEPTOR 1 AND CANCERS . 1 1.1 Metabotropic glutamate receptors in the central nervous system . 2 1.2 Metabotropic glutamate receptors beyond the brain . 3 1.3 Oncogenic properties of metabotropic glutamate receptors . 6 1.3. 1 GPCRs as oncoproteins . 6 1.3. 2 Glutamate signaling in melanoma . 8 1.3. 2.A An introduction to melanoma . 8 1.3. 2.B mGluR1 in melanoma . 13 1.3. 2.C Glutamate receptors in melanoma . 18 1.3. 3 mGluRs in breast cancer . 22 1.3. 3.A An introduction to breast carcinoma . 22 1.3. 3.B Glutamate signaling in breast cancer . 23 1.3. 4 mGluRs and other cancers . 24 1.4 Glutamate signaling as a therapeutic target . 28 1.5 Questions for the future . 31 CHAPTER 2: METABOTROPIC GLUTAMATE RECEPTOR MEDIATES MELANOCYTE TRANSFORMATION VIA TRANSACTIVATION OF IGF-1 RECEPTOR . 34 Abstract . 35 2.
Initiation of ageing process by meiotic and mitotic recombination within the ribosomal DNA genes in Saccharomyces cerevisiae

In the budding yeast of Saccharomyces cerevisiae the tandem repeated of rDNA genes are located on chromosome XII, which is in the nucleolus. There are different types of proteins in the nucleoluskeleton, silencing proteins have got important role in nucleolus. It is shown that meiotic recombination between nonsister chromatids in the rDNA genes are strongly suppressed, and suggested that silencing proteins such as SIR2 are involved in silencing state. It is also shown that nucleolus shows some changes during ageing process. It is claimed that intrachromosomal recombination within the rDNA repeated sequences; producing 3-µm rDNA circles are accumulated with old cell. This study looked at the rDNA breakage in two different types of strain ORD 1181 according to their age. The fine analysis of the rDNA array was performed using restriction endonuclease enzymes, which do not cleave within the rDNA array. The results suggest that there are only meiotic hot regions for chromosome breakage in the old cells within the rDNA array.
The effect of multi-stage modification on the performance of Savonius water turbines under the horizontal axis condition

Abstract Indonesia has the abundant potential of hydropower but not yet processed optimally, which intensely depends on fossil fuel. Hydropower installed in Indonesia is only 11,272 MW, from the estimated potential approximately 94,476 MW. This data shows that 89% of the hydropower potential in Indonesia has not been processed. One of the present efforts to utilize this resource is addressed to develop the Savonius water turbine. Conventional water Savonius turbines have a comprehensible structure and easy to be applied. However, the turbines produce relatively small power, which requires further assessment to improve its performance. The current study is performed by considering geometric changes on the water Savonius turbine to observe their effect on power characteristics. Considered changes are made on the number of stages, and the angle between stages, specifically a single-stage, two-stage 0°, Two-stage 90°, three-stage 0°, and three Stage 120°. The research was carried out by designing simulation model using ANSYS software with CFX Solver. Water speed is determined to 0.8 m/s, while plates with 110 mm in diameter and 110 mm in height are incorporated as rotor configuration. Based on this study, it can be concluded that the addition of the stage affected improving the performance of the Savonius water turbine, where the multi-stage turbine experienced an increment compared to conventional water turbines. The interesting tendency was found on the two-stage rotors with angle of 0° which produced a smaller Cpmax compared to the conventional water Savonius turbines.
Ultra-Wideband (UWB) characteristic estimation of elliptic patch antenna based on machine learning techniques

Abstract In this study, estimation of Ultra-Wideband (UWB) characteristics of microstrip elliptic patch antenna is investigated by means of k-nearest neighborhood algorithm. A total of 16,940 antennas are simulated by changing antenna dimensions and substrate material. Antennas are examined by observing Return Loss and Voltage Standing Wave Ratio (VSWR) characteristics. In the study, classification of antennas in terms of having UWB characteristics results in accuracies higher than 97%. Additionally, Consistency based Feature Selection method is applied to eliminate redundant and irrelevant features. This method yields that substrate material does not affect the UWB characteristics of the antenna. Classification process is repeated for the reduced feature set, reaching to 97.44% accuracy rate. This result is validated by 854 antennas, which are not included in the original antenna set. Antennas are designed for seven different substrate materials keeping all other parameters constant. Computer Simulation Technology Microwave Studio (CST MWS) is used for the design and simulation of the antennas.
Hydrogen Production from Catalytic Polyethylene Terephthalate Waste Reforming Reaction, an overview

Abstract As a sustainable and renewable energy carrier for transition, hydrogen is considered as a key future fuel for the low carbon energy systems. During the past few decades, attention has been given to the conversion of waste materials, including plastics to the production of hydrogen. Studies in this field are of great importance because they resolve numerous problems brought about by plastic waste with other forms of waste. Polyethylene terephthalate (PET) is one of the major products of plastic waste which constitutes a major threat to environmental conservation efforts and harms living organism. Phenol has been chosen in this study as a solvent for PET to produce hydrogen because of unwanted liquid product in the bio-oil. This research investigates catalytic steam reforming of phenol with dissolved PET for hydrogen production. The aim of this study was the review of a highly active and stable catalyst for hydrogen production from steam reforming waste products. The analysis of product composition indicated that steam reforming of PET-phenol generally produced a high amount of aliphatic branched-chain compounds, together with a moderate amount of cyclic compounds. The reaction conditions also led to the alkylation of phenol by the reforming products from the PET-phenol solution with and without the catalyst. In conclusion, this study explored new ways to use l product derived from waste plastic materials. It provides a promising clean technology, which employed polyethylene terephthalate waste dissolved in phenol (as a solvent) for hydrogen production.