Miracle-dz/UniFAR-FTUs huggingface dataset:
Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients

Objective:Topoisomerase 1 (topo-1) is an important target for the treatment of metastatic colorectal cancer (CRC). The aim of the present study was to evaluate the correlation between topo-1 single-nucleotide polymorphisms (SNPs) and clinical outcome in metastatic CRC (mCRC) patients. Methods: With the use of specific software (PROMO 3.0), we performed an in silico analysis of topo-1 promoter SNPs; the rs6072249 and rs34282819 SNPs were included in the study. DNA was extracted from 105 mCRC patients treated with FOLFIRI ± bevacizumab in the first line. SNP genotyping was performed by real-time PCR. Genotypes were correlated with clinical parameters (objective response rate, progression-free survival, and overall survival). Results: No single genotype was significantly associated with clinical variables. The G allelic variant of rs6072249 topo-1 SNP is responsible for GC factor and X-box-binding protein transcription factor binding. The same allelic variant showed a nonsignificant trend toward a shorter progression-free survival (GG, 7.5 months; other genotypes, 9.3 months; HR 1.823, 95% CI 0.8904-3.734; p = 0.1). Conclusion: Further analyses are needed to confirm that the topo-1 SNP rs6072249 and transcription factor interaction could be a part of tools to predict clinical outcome in mCRC patients treated with irinotecan-based regimens.
Recomendaciones generales para el manejo práctico de la insuficiencia cardiaca

DEFINICIÓN Insuficiencia cardiaca (IC) es un síndrome que se origina como consecuencia de algún desorden funcional o estructural del corazón originando una incapacidad para mantener el gasto cardiaco necesario para cubrir los requerimientos metabólicos del organismo. La fisiopatología de la IC se basa en la disfunción y/o muerte de los miocitos que origina cambios en la geometría del ventrículo (dilatación, hipertrofia, remodelación) con la activación adrenérgica, del sistema renina-angiotensinaaldosterona y de los péptidos natriuréticos. La activación persistente de estos tres factores puede originar efectos adversos como: • Vasoconstricción excesiva. • Vasoconstricción coronaria. • Retención de agua y sal. • Anomalías electrolíticas. • Arritmias. • Hipertensión venocapilar, que produce edema sistémico y pulmonar. En el Perú, según el Ministerio de Salud (Minsa), en el año 2000 la IC fue responsable del 2,6% de mortalidad y ocupó el décimo lugar dentro de todas las causas de muerte.
Integral ratios of factorials and algebraic hypergeometric functions

Sketch of proof of a theorem relating the two subjects of the title. It can be thought as an extension of results of Landau for the classical hypergeometric function. It relies on the characterization of algebraic hypergeometric functions of Beukers and Heckman. In the process we also show that a variant of a classical construction of Bezout (producing a quadratic form, the Bezoutian, out of two polynomials in one variable) gives the Hermitian form fixed by the monodromy group, up to scaling.
Can “Low-Fat” Nutrition Labels Lead to Obesity?

In this era of increasing obesity and increasing threats of legislation and regulation of food marketing practices, regulatory agencies have pointedly asked how “low-fat” nutrition claims may influence food consumption. The authors develop and test a framework that contends that low-fat nutrition labels increase food intake by (1) increasing perceptions of the appropriate serving size and (2) decreasing consumption guilt. Three studies show that low-fat labels lead all consumers—particularly those who are overweight—to overeat snack foods. Furthermore, salient objective serving-size information (e.g., “Contains 2 Servings”) reduces overeating among guilt-prone, normal-weight consumers but not among overweight consumers. With consumer welfare and corporate profitability in mind, the authors suggest win-win packaging and labeling insights for public policy officials and food marketers.
Performance Analysis of Optimization Techniques for SQL Multi Query Expressions Over Text Databases in RDBMS

This paper begins by introducing the concept of Optimization in SQL Queries. The introductory section gives brief information on the strategies, an optimizer should follow. In order to examine the role of query optimization process in RDBMS, this paper will look at both static and dynamic process of optimization as well as all the general aspects of query optimization. The paper will then explore major principles of query optimization process with volcano query optimization. An enhancement to volcano query optimizer is proposed by adding some set of transformation rules and operators. The search space principle will elaborate various types of query tree. The search strategy principle will elaborate various search strategy techniques including dynamic and greedy algorithms that will play a big role in improving the overall efficiency of relational database systems. Finally, this paper ends with the conclusion of highlighted issues and solutions.
LANDFILL LEACHATE TREATMENT BY COMBINATION OF ELECTRO - FENTON AND SEQUENCING BATCH REACTOR METHOD NUR FATIHAH BT MUHAMAD HANAFI A thesis submitted in fulfillment of the requirement for the award of the Degree of Master of Civil Engineering

Landfill leachate contains a large amount of organic, inorganic and heavy metal contents. Untreated leachate is a potential source to effect of soil, surface and groundwater. The combined treatment offers an alternative technique in dealing to leachate treatment. This research is to determine the effectiveness of combined electro-Fenton and sequencing batch reactor (SBR) method on the removal of SS, colour, COD and NH3-N. The experimental involved three major parts were coagulation-flocculation, electro-Fenton and SBR method. This process could be operated independently in a batch mode and optimum conditions for each treatment were identified. In the combined process, leachate was first fed to coagulationflocculation for pre-treatment. Then, the effluent from that process was oxidized in electro-Fenton process. The final process is the effluent of leachate was fed to a SBR method. The combined treatment was operated under the optimum conditions for all the processes. The result of coagulation-flocculation shown PAC is more effective at 2500 mg/L of optimum dosage. After coagulation-flocculation process, the removal of SS, colour, COD and NH3-N were 80%, 77%, 61% and 35% respectively. The result of electro-Fenton shown Al-Al is more effective at 200 A/m 2 of optimum current density, 25 minutes of optimum reaction time, 4 of optimum pH, 800 mg/L of optimum H2O2 dosage and 1000 mg/L of optimum FeSO4•7H2O dosage. After electro-Fenton process, the removal of SS, colour, COD and NH3-N were 87%, 95%, 82% and 65% respectively. The final process of SBR effluent was approaching neutral pH at 6.90 at 2800 mg/L of optimum MLSS and 6 h of optimum reaction time. The overall performance of combined treatment on the removal of SS, colour, COD and NH3-N were 84%, 82%, 87% and 78% respectively. Thus, this combined treatment offers as an alternative technique for landfill leachate treatment on the removal of pollutants.
Twee families met stijve spieren:: de niet-dystrofische myotonieën

Myotonie is een klinisch waarneembaar verschijnsel dat gekenmerkt wordt door vertraagde spierrelaxatie. Patiënten ervaren dit als spierstijfheid. Er bestaan verschillende ziektebeelden met myotonie. De bekendste is myotone dystrofie (syndroom van Curschmann-Steinert). De niet-dystrofische myotoniesyndromen zijn zeldzamer maar gezien het verschil in klinisch beloop, prognose en erfelijkheid ten opzichte van myotone dystrofie, is het belangrijk deze syndromen te herkennen en te diagnosticeren. Niet-dystrofische myotonieën behoren tot kanalopathieën (ionkanaalziekten) van de skeletspier en worden onderverdeeld in aandoeningen van het chloorof natriumkanaal. In tegenstelling tot myotone dystrofie is er bij deze aandoeningen geen sprake van spierdystrofie, multiorgaancomplicaties of genetische anticipatie. Klinisch zijn de verschillende niet-dystrofische myotoniesyndromen soms moeilijk van elkaar te onderscheiden. Tegenwoordig is onderscheid naar de verantwoordelijke mutaties mogelijk met DNA-diagnostiek. (Tijdschr Neurol Neurochir 2006;107:54-61)
WEB CLASSIFICATION APPROACH USING REDUCED VECTOR REPRESENTATION MODEL BASED ON HTML TAGS

Automatic web page classification plays an essential role in information retrieval, web mining and web semantics applications. Web pages have special characteristics (such as HTML tags, hyperlinks, etc.…) that make their classification different from standard text categorization. Thus, when applied to web data, traditional text classifiers do not usually produce promising results. In this paper, we propose an approach which categorizes web pages by exploiting plain text and text contained in HTML tags. Our method operates in two steps. In step 1, we use Support Vector Machine classifier (SVM) to generate, for each target web page (page to classify), reduced vector representation based on plain text and text from HTML tags. In Step 2, we submit this vector representation to Naive Bayes (NB) algorithm to determine the final class for the target page. We conducted our experiments on two large datasets of pages from ODP (Open Directory Project) and WebKB (Web Knowledge Base), which are accidentally discovered to suffer from a lot of missing HTML tags. The results prove that NB classifier, supported by our model and using HTML tags content combined with plain text, (1) performs significantly better than NB classifier using text alone in terms of both Micro-F1 and Macro-F1 measures and even with the presence of missing HTML tags, (2) performs consistently with respect to category distribution and (3) outperforms NB classifier, using text alone, simply with the use of very basic handling techniques of missing HTML tags.
ALLOCATION OF AIR CARGO CAPACITY TO DECENTRALIZED SALES AGENTS

A global airline has cargo operations in multiple nations and locations. In this paper, we study optimal policies for managing sales agents. At present, for each flight, headquarters retains a portion of the total capacity and allocates the rest to sales agents. Capacity retained by the headquarters is used only after the allocated capacity is exhausted. While each agent is allowed to use any policy to fill the capacity allocated to him, the capacity retained by the headquarters is allocated based on a control policy. In this talk, we present the policies being employed by the airline and discuss the underlying optimization problem. Assuming that each agent is a risk averse agent whose effort level determines the demand rates, we then analyze a set of alternate policies that try to maximize expected revenues for the airlines and check the optimality of the current policy.
Higher K-theory of Toric stacks

In this paper, we develop several techniques for computing the higher G-theory and K-theory of quotient stacks. Our main results for computing these groups are in terms of spectral sequences. We show that these spectral sequences degenerate in the case of many toric stacks, thereby providing an efficient computation of their higher K-theory. We apply our main results to give explicit description for the higher K-theory for many smooth toric stacks. As another application, we describe the higher K-theory of toric stack bundles over smooth base schemes.
Collatz Conjecture

My math 301 Term paper will be concerned with exploring the Collatz conjecture. I will discuss the importance and interest of this conjecture; what progress has been made on this problem and who made it. I will also explore whether any connections have been made between the Collatz conjecture and other mathematical problems.
Unfair and deceptive practices

In enacting the Wheeler–Lea Amendments to the Federal Trade Commission Act in 1938, Congress dramatically expanded the power of the Federal Trade Commission. Congress broadened the FTC's organic power from the prevention of “unfair methods of competition in commerce” to include prevention of “unfair or deceptive acts or practices in commerce. ” Theories of unfairness and deception now form the basis of FTC privacy law. This chapter traces the contours of this broad prohibition, focusing on the case-by-case development of the doctrine and policy statements. It is analyzed separately here from the subject-matter chapters in Part II because the FTC's authorities to police unfair and deceptive trade practices are broader than many realize in privacy cases. This chapter makes clear that the FTC could go further in policing privacy practices based on precedent in advertising and other cases. Furthermore, the development of the substantiation doctrine (discussed below) could have profound effects on the market for privacy-protective services when competition on privacy begins in earnest. Cynics say that the commission does not use an objective or standardized definition of unfairness and deception. There is some truth to that, in part because, by statute and by custom, courts defer to the Commission's judgment concerning what is deceptive and unfair. As we saw in Chapter 1, Congress affirmatively made a policy decision to choose vague language in 1914 and again in 1938 because business practices and technology were constantly evolving, causing new problems that Congress could not quickly act to remedy. Section 5 does not have a static meaning, and lawyers will always have to grapple with its application in new business contexts. As two FTC attorneys put it in 1962, “[Section 5] cannot be defined in terms of constants. More broadly, it is a recognition of an ever-evolving commercial dexterity and the personal impact of economic power as important dimensions of trade. Its underlying proposition is that a free competitive society must have some means of preventing that very freedom to compete from destroying our economic system. ” It is also clear that Congress chose to free the FTC from the restraints imposed by the common law in fraud matters. Yet, imposing common law requirements tends to be the first kind of reform proposed by critics of the FTC.
Spatial characteristics in decomposition rate of foliar litter and controlling factors in Chinese forest ecosystems

Aims We aim to construct a national database for decomposition rate of forest foliar litter and to investigate the effects of controlling factors concerning geography (i.e. latitude, longitude, and altitude), climate (i.e. mean annual temperature and mean annual precipitation), and litter quality (i.e. the concentrations of N, P, K, and lignin, C:N ratio, and lignin:N ratio) on litter decomposition. Methods We compiled a large dataset on decomposition constant (i.e. k value, which indicates the rate of litter decomposition) for foliar litter in Chinese forest ecosystems covering 74 study sites, and conducted simple and multiple regression analyses to explore the relationships of the k value with the controlling factors at the national scale. Important findings The k value showed a tendency to decrease with latitude, longitude, altitude, lignin content, C:N, and lignin:N of litter, and to increase with mean annual temperature, mean annual precipitation, and litter nutrient concentrations (N, P and K) at the national scale. Single factors such as climate, litter quality, and geographic variable only explained 0.1%–30.3% of the variation in the rate of litter decomposition. However, a combination of climatic factors (mean annual temperature and mean annual precipitation) and latitude accounted for 34.1% of the variation in the rate of litter decomposition. Similarly, a combination of N, K, lignin, and lignin:N accounted for 21.7% of the variation in the rate of litter decomposition. Altitude, mean annual temperature, mean annual precipitation, N, K, and lignin:N collectively accounted for 74.4% of the variation in the rate of litter decomposition. Our results suggest that climate is the most important regulator of litter decomposition at the 530 植物生态学报 Chinese Journal of Plant Ecology 2014, 38 (6): 529–539 www.plant-ecology.com national scale and that the effects of litter quality is relatively small compared to climate.
Growth Function and Vc-dimension

1 Review of VC theory Our primary interest so far is deriving the generalization bound for the binary classifiers. We have studied the Rademacher complexity techniques, and shown that the VC bound is an upper bound of the Rademacher complexity bound. For a binary classification with 0-1 loss l, we have R m (l • H) ≤ 2 log g H (m) m (1) where H = {h : X → {+1, −1}} is a hypothesis space. The growth function g H (m) is defined to be the number of ways the hypothesis space H assign an arbitrary m point sample set (Definition 1).
Model superkondenzatora sa eksperimentalnom verifikacijom rezultata simulacije

U ovom radu je dat kratak istorijski pregled, kao i prikaz najznacajnih tehnologija izrade i primjena superkondenzatora. Realizovan je model superkondenzatora na kome je uraneno niz simulacija za koje je dobijena dobra saglasnost sa eksperimentalnim rezultatima. Predstavljene su i osnovne tehnike punjenja superkondenzatora sa posebnim osvrtom na prekidacke punjace u okviru kojih je predstavljen laboratorijski prototip punjaca koji je koriscen za verifikaciju rezultata simulacije. Na taj nacin ovaj rad predstavlja zaokružen projekat od idejnog rjesenja do prakticne realizacije.
Toward a Statistical Theory of Learning.

Improved experimental techniques for the study of conditioning and simple discrimination learning enable the present day investigator to obtain data which are sufficiently orderly and reproducible to support exact quantitative predictions of behavior. Analogy with other sciences suggests that full utilization of these techniques in the analysis of learning processes will depend to some extent upon a comparable refinement of theoretical concepts and methods. The necessary interplay between theory and experiment has been hindered, however, by the fact that none of the many current theories of learning commands general agreement among researchers. It seems likely that progress toward a common frame of reference will be slow so long as most theories are built around verbally defined hypothetical constructs which are not susceptible to unequivocal verification. While awaiting resolution of the many apparent disparities among competing theories, it may be advantageous to systematize well established empirical relationships at a peripheral, statistical level of analysis. The possibility of agreement on a theoretical framework, at least in certain intensively studied areas, may be maximized by defining concepts in terms of experimentally manipulable variables, and developing the consequences of assumptions by strict mathematical reasoning. This essay will introduce a series of
Una nueva terapéutica no-farmacologica para la hipertensión arterial resistente

Se informa acerca de dos pacientes con hipertension arterial resistente tratada exitosamente con denervacion renal. Este novedoso tratamiento consiste en la ablacion parcial de la inervacion renal mediante la aplicacion de radiofrecuencia en la superficie luminal de las arterias renales empleando tecnicas de cateterismo vascular. Estos son los primeros casos realizados en el Instituto Nacional del Corazon (INCOR) EsSalud y representan el inicio de una gran experiencia para ofrecer una alternativa mas en el manejo de este tipo de pacientes.
“Consumption, was it?”

Mita's major research areas are in Energy Economics, Sustainability, Applied Industrial Organisation and International Trade. Mita has published widely in peer-reviewed journals including in Energy Economics, International Journal of Industrial Organisation, International Journal of Production Economics, World Economy, Review of Industrial Organisation and in Applied Energy. She has held visiting positions in the Australian National University, Curtin University, Doshisha University, University of East Anglia and in the OECD. Mita has received numerous internal grants and external grants from the Australian Research Council, Tyre Australia and National Science Council (Taiwan). Mita is the recipient of the annual award in 2017 from the Applied Energy Society for her research on renewable energy sources. Her focus on interdisciplinary research has extended collaborations with Engineering Faculty. She has been the Course Director of Masters Program in Economics since 2016. Before joining Monash, Mita has taught at the University of Tasmania and at the University of New Castle. Details on her research can be found at: https://scholar.google. com.au/citations? user=VTukFXIAAAAJ&hl=en https://sites.google. com/monash.edu/mita-bhattacharya/home
Putting ALLHAT into Perspective

Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (the ALLHAT study), reported in late 2002,1 drew the interest of media journalists as well as the attention of the medical community and the health care industry. The nation’s leading newspapers and television networks scrambled to provide coverage of the significant findings. Although the abbreviated versions that made the headlines contained accurate information, the study outcomes and their implications were oversimplified and overinterpreted. Readers and viewers came away thinking that an inexpensive, 50-year-old drug, commonly known as a diuretic (“water pill”), worked for everyone as well as the newer, more expensive drugs for hypertension. Following this thread, some reporters and their interviewed subjects implicated the pharmaceutical industry as a villain for its role in developing and marketing the alternative drugs for the treatment of hypertension. Now that experts in the field of hypertension have had time to evaluate the voluminous ALLHAT report, they have begun to question the strength of the study’s design, the accuracy of the conclusions, and the flamboyant character of the researchers’ announcement to the press.2–4 Adding to the confusion, a similar, large-population study reported contradictory findings5 in February 2003, casting doubt on the validity of claims made by the ALLHAT researchers. This article does not seek to diminish the relevance or importance of ALLHAT but attempts to approach the findings in the context of the entire body of relevant hypertension research, current clinical practice, and existing national guidelines. The reality is that diuretics already top the list of recommended first-line pharmaceutical treatments for hypertension; for most patients, however, diuretics alone are ineffective in lowering and maintaining acceptable blood pressure levels over time. It often becomes necessary to add another type of antihypertensive drug or, in some cases, to switch to a different class of drug.
^im^sm Mm

This paper investigates whether peer effects play an important role in retirement savings decisions. We use individual data from the staff of a university to study whether individual decisions to enroll in a Tax Deferred Account plan sponsored by the university (and the choice of the mutual fund vendor for people who choose to enroll) are affected by the decisions of other employees in the same department. To overcome the identification problems, we separate the departments into sub-groups (along gender, status, age, and tenure lines) and we instrument the average participation of each peer group by the salary or tenure structure in this group. Our results suggest that peer effects are important. We find significant owngroup peer effect on participation and on vendor's choice, but no cross-group peer effects. (JEL D83, 122) *MIT, Department of Economics E52-252g, 50 Memorial Drive, Cambridge, MA 02142, eduflo@mit.edu. Harvard University, Department of Economics, Littauer Center, Cambridge, MA 02138, saez@fas.harvard. edu. We thank Abhijit Banerjee, David Cutler, Jonathan Gruber, Lawrence Katz, Michael Kremer, Philip Lima, Brigitte Madrian, Sendhil Mullainathan, Kaivan Munshi, Linda Nolan, James Poterba, and Rosemary Rudnicki for helpful disf ussions, and Kirsten Carter, Regina Perris, and Polly Price for giving us access to the data.