Miracle-dz/UniFAR-FTUs huggingface dataset:
La chaîne d'analyse syntaxique de LEOPAR

LEOPAR est un analyseur syntaxique fonde sur le formalisme des grammaires d'interaction, integre dans une chaine d'outils visant avant tout a la precision et la couverture linguistique. A l'aide de XMG, il est possible de construire des grammaires de facon semi-automatique a partir de connaissances linguistiques. Ces grammaires sont ensuite ancrees a l'aide de lexiques independants d'un quelconque formalisme. Les grammaires ancrees sont enfin utilisees par LEOPAR pour analyser des corpus bruts et produire des sorties sous forme d'arbres syntagmatiques ou de structures de dependances.
A study of customer satisfaction on select service dimensions with reference to ATMs and CDMs services in Oman

In order to provide better services to customers, banks have been using different types of online banking, ATMs, and CDMs. A very large proportion of bank customers use ATMs and CDMs for their routine operations. This study endeavors to gauge the customer satisfaction of ATM and CDM users using six dimensionsaccessibility, convenience, efficiency, responsiveness, security & privacy, and reliability. These dimensions were selected based on the literature review and experts’ suggestions. Questionnaire, having closed ended questions only and duly tested in a pilot study, was used for primary data collection. A research model has been developed which consists of the six dimensions as response variables and customer satisfaction as latent variable. Descriptive statistics and structural equation modeling (SEM) technics were applied. The results revealed that all the selected dimensions are found to be significant in influencing the customer satisfaction level.
Novel methods and strategies in the discovery of TACE inhibitors

Introduction: Tumor necrosis factor-α (TNF-α) is a key player in inflammation and joint damage in rheumatoid arthritis (RA). One treatment approach to exclude TNF-α from the biological system is by inhibiting tumor necrosis factor-alpha converting enzyme (TACE), the enzyme responsible for the production of its active form. To date, a number of TACE inhibitors have been reported in the literature from various strategies and methods. Areas covered: The following article presents the design and development strategies for the discovery of novel TACE inhibitors which could be of therapeutic utility for the alleviation of inflammatory conditions. The review is based on literature of the subject from 2005 onward. Expert opinion: Discovery of a selective TACE inhibitor has remained a major goal for many academic and pharmaceutical industrial research laboratories for quite some time. Identification of selective TACE inhibitors has proved elusive until recently due to structural similarities between TACE and MMPs. The differences in the shape and size of the S1′ pocket of TACE and MMPs could be exploited to design selective TACE inhibitors devoid of any MMP inhibitory activity in the near future. It would be a Herculean task to develop a specific TACE inhibitor for clinical treatment of RA because binding subsites of TACE and MMPs are quite similar. However, developments taking place currently in the field as well as in the application of molecular modeling techniques at a wider scale could yet provide clinically useful selective TACE inhibitors in the not too distant future.
A new fast and reliable method for islanding detection based on transient signal

This paper presents a new method for islanding detection in distributed generations. In the proposed method, the current transient signal at the utility side of the circuit breaker is processed using wavelet transform. Also the maximum value of wavelet transform distinguishes islanding conditions from non-islanding ones. This technique is very effective in islanding detection at different target Distributed Generation (DG) locations in the distribution network including multiple distributed generations. Because of utilizing transient signal in detecting the islanding condition, the proposed idea has not needed to inverter control system response.
Understanding service quality and reputation effects on purchase behavior through image: the moderating roles of service reliability

Abstract Measuring the customers’ perspective with airlines’ service quality and their purchases is meaningful for academic researchers, practical management, and increasingly competitive environment. The sampling of 630 passengers jointly used structural equation modeling and the regression method to examine the proposed hypothesis. The results showed that airlines’ brand images for corporate and service reliability independently and jointly influence purchase behavior. The study has three important findings for the air-transport and airline-management literature. First, in contrast to the portrait of service quality influences, we find that when customers perceive the service quality and corporate reputation of airline provided, it will influence their evaluation of brand image, which affects their purchase intention. Next, we found that perceived value may influence repurchase intention through word of mouth (WOM). Finally, the concepts of mediation–moderation were introduced; these concepts have seldom been either examined or tested in previous studies.
Clinical course of sorafenib treatment in patients with hepatocellular carcinoma

Abstract Objective. Sorafenib has been shown to improve survival of patients with advanced hepatocellular carcinoma (HCC). However, its tolerance in clinical practice has not been well evaluated, and whether sorafenib should be continued in cases of tumor progression or intolerance has not been established. The authors retrospectively assessed sorafenib tolerability, and evaluated the clinical course in patients who showed progression during sorafenib treatment. Material and methods. Between March 2008 and July 2010, 80 patients with advanced HCC were treated with sorafenib. Results. With a median of 78.5 days of treatment, 15% discontinued sorafenib due to adverse events. The duration was significantly longer in patients with Child–Pugh class A liver function (233 ± 240 days) than in those with Child–Pugh class B (100 ± 136 days; p = 0.006). The overall progression rate was 53% (43/80), with a median time to progression of 105 days (95% confidence interval, 59–150 days). After progression, 14 patients received conservative care only (group 1), 14 continued sorafenib monotherapy (group 2), 6 changed to treatment without sorafenib (group 3) and 9 underwent additional treatment with concomitant sorafenib (group 4). Survival after progression was significantly better in groups 2, 3 and 4 than in group 1 (p = 0.001). Conclusions. Sorafenib was tolerable for most patients in clinical practice and may be continued in patients who show progression during sorafenib therapy. However, it was less well tolerated in patients with Child–Pugh class B liver function and should be used with caution in these patients.
Energy Consumers' Perspectives on Smart Meter Data: Privacy and Unjust Algorithmic Discrimination

This chapter employs the framework of contextual integrity related to privacy developed by Nissenbaum as a tool to understand consumer response to implementation of residential smart metering technology. To identify and understand specific changes in information practices brought about by the introduction of smart meters, energy consumers were interviewed, read a description of planned smart grid/meter implementation, and were asked to reflect on changes in the key actors involved, information attributes, and principles of transmission. Areas where new practices emerge with the introduction of residential smart meters were then highlighted as potential problems (privacy violations). Issues identified in this study included concern about unauthorized use and sharing of personal data, data leaks or spoofing via hacking, the blurring distinction between the home and public space, and inferences made from new data types aggregated with other personal data that could be used to unjustly discriminate against individuals or groups.
The impact of in-house training on the diversity dimensions of employee productivity in the South Africa workplace

The aim of this article is to determine the impact of in-house training (defined as any training provided by firms in the workplace) on employee productivity, employee remuneration and net employee productivity gains when diversity attributes of the workplace are taken into consideration. The manufacturing industry of Gauteng Province of South Africa is used as a case study. Fixed-effect panel data estimations were performed in order to determine the diversity-based employee productivity, remuneration and net productivity differentials of in-house training. The results accentuate the important positive productivity, remuneration and net productivity spill-over effects created by in-house training opportunities. The outcomes of the study also confirm the importance of a workplace that is more gender diverse, racial diverse and in which skilled and older experienced employees are retained if the productivity spill-over effects generated by in-house training opportunities are to be enhanced.
Reactive Oxygen Species by Isoflurane Mediates Inhibition of Nuclear Factor &kgr;B Activation in Lipopolysaccharide-Induced Acute Inflammation of the Lung

BACKGROUND:Although anesthetic-induced inhibition of lipopolysaccharide (LPS)-induced lung injury has been recognized, the underlying mechanism is obscure. Some studies suggest that reactive oxygen species (ROS) by isoflurane play a crucial role for anesthetic-induced protective effects on the brain or the heart; however, it still remains controversial. In this study, we examined the role of isoflurane-derived ROS in isoflurane-induced inhibition of lung injury and nuclear factor &kgr;B (NF&kgr;B) activation in LPS-challenged rat lungs. METHODS:Male Sprague-Dawley rats were subjected to inhalation of 1.0 minimum alveolar concentration of isoflurane for 60 minutes, and intratracheal LPS 0.1 mg was administered 60 minutes later. In some cases, ROS scavenger, 2-mercaptopropinyl glycine or N-acetylcysteine was given 30 minutes before isoflurane. ROS generation was measured by fluorometer before LPS challenge and 4 hours after. Isoflurane’s preconditioning effect was assessed by histologic examination, protein content, neutrophil recruitment, and determination of tumor necrosis factor (TNF)-&agr;, interleukin (IL)-1&bgr;, and IL-6 levels in bronchoalveolar lavage fluid and lung tissue. Western blotting measured phosphorylation of inhibitory &kgr;B &agr; (ser 32/36), NF&kgr;B p65, and inducible nitric oxide synthase (iNOS). TNF-&agr; and IL-6 mRNA expression and immunofluorescence staining for iNOS were also assessed. RESULTS:Isoflurane preconditioning reduced inflammatory lung injury and TNF-&agr;, IL-1&bgr;, and IL-6 release in the lung. Isoflurane upregulated ROS generation before LPS but inhibited a ROS burst after LPS challenge. ROS scavenger administration before isoflurane abolished the isoflurane preconditioning effect as well as isoflurane-induced inhibition of phosphorylation of inhibitory &kgr;B&agr;, NF&kgr;B p65, iNOS activation, and mRNA expression of TNF-&agr; and IL-6 in acute LPS-challenged lungs. CONCLUSIONS:This study suggests a crucial role of upregulated ROS generation by isoflurane for modification of inflammatory pathways by isoflurane preconditioning in acute inflammation of the lung.
Modelling the usage of mobile banking apps from the perspective of bank customers in Jordan

Mobile banking, M-banking or MB is one of the latest mobile technological booms that allow people to have access to their bank accounts and perform transactions anytime and anywhere. Mobile banking allows bank customers to perform banking services via their portable devices or smart phones, such as: general inquiries, account management, payment of bills, find ATM locations, transferring money and other financial banking transactions. Therefore, such technology enhanced the customer satisfaction and banking services as well; banks have now developed from the traditional branch banking services to e-services, which gives banks’ customers more flexibility and convenience to perform transactions. Nevertheless, the adoption rate of mobile banking technology is not ideal. Despite the large amounts of effort and money being invested, the adoption of electronic banking services in Jordan is not in line with what was expected, and Jordanian banking customers are still slow to adopt these technologies. As it is in the early stages of development and implementation, mobile banking-related concerns and matters have yet to be examined empirically in the Jordanian context. In addition, there is a scarcity of literature addressing customer intention and usage of mobile banking apps by Jordanian banking customers.
Simulating Nuclear Events in a TCAD Model of a High-Density SEU Hardened SRAM Technology

The interaction between a heavy ion and the overlayer materials in an integrated circuit may result in a nuclear reaction. This reaction leads to a charge generation profile that is substantially altered from the profile generated during a direct ionization event. In this work, nuclear reactions are integrated into the modeling of the SEU response of an SRAM cell using GEANT4-based simulations. The simulated transient response is compared to the response obtained using a typical heavy ion model that includes only direct ionization
Maintaining Operational Readiness in a Warning Environment: Development and Use of the Situation Awareness Display System (SADS)

During the Spring of 2004, the Weather Forecast Office in Norman, Oklahoma (WFO OUN), Warning Decision Training Branch (WDTB), and the NWS Southern Region Headquarters (NWS SRH) collaborated to design and implement a PC-based Situation Awareness Display System (SADS). The SADS resides at WFO Norman and is currently being implemented into severe weather operations. The concept of the SADS display is to help the event coordinator keep a high level of situation awareness (SA) (Endsley 1995) during significant weather operations. The display is not unlike that employed by NASA and by military command centers where assimilating and displaying relevant data sets help the critical decision makers keep a high level of awareness of the state of the mission. The paper will discuss the proof of concept of this system as well as lessons learned in its inaugural season. The design of the display will be discussed, as well as the efforts expended in designing relevant software to take advantage of non-traditional data sets including television and web cams. Cautions with regard to the ineffective use of such systems will also be discussed.
Airline consumers' use of Twitter for customer service : the case of Icelandair

This exploratory case study uses an interpretative phenomenological approach to explore how and why Icelandair consumers utilize Twitter as a platform to communicate with the brand. The competition within the airline industry is high and in order to differentiate themselves from their competitors, airlines need to gain a better understanding of their consumers to improve the quality of their service. With the increased usage of social media, companies are beginning to integrate these platforms into their marketing strategy. Twitter is a social media platform that has gained prominence as a communication channel between consumers and brands. Twitter is a public platform, therefore making it easy for others to observe interactions. This voluntary exposure adds an increased pressure for companies to do well in a demanding environment. The Icelandic airline Icelandair was chosen as a case study since the airline industry is one of the most active industries on social media and airline consumers rely heavily on customer service. The author conducted ten semi-structured in-depth interviews with Icelandair’s consumers that all had contacted the airline on Twitter. The interviews were analyzed with an interpretative phenomenological approach were themes were identified and the transcribed data interpreted. Findings offer insights into how consumers perceive the Twitter platform as a communication channel. The interviews with Icelandair’s consumers provide a deeper understanding of what consumers value when they communicate with brands on Twitter. With a better understanding of their consumers, Icelandair can improve their marketing strategies on Twitter.
Safety, tolerability, and short-term efficacy of intravenous lidocaine infusions for the treatment of chronic pain in adolescents and young adults: a preliminary report.

OBJECTIVE To provide pediatric care providers with insight into lidocaine infusions for analgesia. AIM This retrospective review was conducted to describe lidocaine infusions for chronic refractory pain within the adolescent and young adult pain population. SETTING Although lidocaine infusions have been used for pain management in adults, their analgesic utility in the adolescent and young adult population is limited and so is the evidence for their efficacy and safety. METHODS After Institutional Board Review approval, a retrospective review of efficacy and safety data for analgesic use of lidocaine was conducted. RESULTS Fifteen patients received 58 infusions with 76% receiving relief where maximum relief was seen among patients with starting pain scores ≥6/10 (mean reduction 2.3 vs. 0.5, P value = 0.006) and when a patient had three or more infusions (mean reduction 1.7 compared with 1.2). No serious side effects were encountered, but only mild or moderate side effects that did not require any intervention. Incidence of tingling or numbness and nausea or vomiting seemed to correlate with total dose of lidocaine per kilogram body weight. Patients reported reduced pain scores (6.3 ± 2.3 to 4.6 ± 2.5 before compared with after the infusion [as mean ± standard deviation]) during 80% of infusions. CONCLUSIONS Our limited experience suggests that lidocaine infusions are well tolerated in the adolescent and young adult pain population, with side effects resolving quickly with interruption or discontinuation of the infusion if necessary. Future studies are warranted to examine safety, efficacy, mechanism of actions, and its long-term impact on a developing central nervous system.
Studies on Z-Fraction. I. Isolation and partial characterization of low molecular weight ligand-binding protein from rat hepatic cytosol.

The Z-fraction has been defined operationally as a ligand-binding (bilirubin sulfobromophthalein) portion of rat hepatic cytosol that elutes in the molecular weight region of 10(4) daltons after gel filtration. Polyacrylamide gel electrophoreses under different conditions, as well as binding stoichiometry, confirm the anticipated heterogeneity of the Z-fraction. Three factors have contributed to the subsequent resolution of the Z-fraction and partial characterization of that protein within the fraction with ligand-binding properties (Z-protein): (1) the use of hexachlorophene as ligand; (2) the inclusion of glycerol, 20%, during isolation to prevent aggregation and loss of binding-activity; and (3) the development of a charcoal binding assay. Upon ion exchange chromatography, the Z-fraction resolves into a group of distinct protein components and an unidentified material with a high 260/280 nm absorbancy ratio. The one protein component with binding capacity exhibits homogeneity on polyacrylamide gel electrophoresis (11% gel, Ann. N.Y. Acad. Sci. 121, 404-427, 1964; and 15% gel with SDS). With use of the charcoal method, apparent dissociation constants for the interaction between Z-protein and hexachlorophene, bilirubin and L-thyroxine, were found to be 20, 50, and 350 muM, respectively. The Scatchard plot generated upon extrapolation an n value of 1.0 with assumption of a molecular weight for Z-protein of 10(4) daltons.
Análise Preliminar de um Processo para Identificação e Alinhamento de Seqüências Homólogas para Proteínas com Estrutura Resolvida

ISSN 1677-8464O Homology-derived Structures of Proteins (HSSP) euma base de dados que agrega informacoes deproteinas com estrutura tridimensional resolvida asequencias de proteinas sem estrutura (Sander S Dodge et al., 1998). Para cada arquivodo Protein Data Bank - PDB (Berman et al., 2000), oHSSP possui um arquivo que relata um alinhamentoformado por sequencias homologas obtidas da basede dados de sequencias de proteinas SWISS-PROT(Bairoch & Apweiler, 2000). Este alinhamento econstruido por um metodo iterativo baseado emprogramacao dinâmica, que perfaz um processo dealinhamento de perfis (profile) de sequencias. Umafuncao de threshold para homologia estrutural (Sander& Schneider, 1991) e utilizada para decidir se umasequencia e considerada homologa ou nao. O HSSPpode ser utilizado para definicao de padroes desequencia com significado estrutural e para estudo deevolucao e dobramento de proteinas, entre outrasaplicacoes.No Sting Millennium Suite (SMS) (Neshich et al.,2003), ferramenta desenvolvida pelo Nucleo deBioinformatica Estrutural (NBI) da Embrapa InformaticaAgropecuaria, disponivel no site http://sms.cbi. cnptia.embrapa. br, o HSSP e utilizado paraanalise do grau de conservacao de residuos no contextoestrutural, atraves do valor de Entropia Relativa,relatado para cada posicao de cada alinhamento.Entretanto, o fato da Entropia Relativa ser extraida doHSSP restringe a disponibilidade deste parâmetroaqueles arquivos PDBs considerados na atualizacaomais recente do HSSP. Assim, ele pode nao estardisponivel para arquivos PDBs recentes e ainda naoprocessados pelo HSSP. Alem disso, como os dadosdo HSSP sao derivados dos dados do PDB, a EntropiaRelativa nunca esta disponivel para arquivos locaiscorrespondentes a estruturas nao depositados no PDB(em processo de resolucao ou modelados porhomologia). Desta forma, para tornar o valor doparâmetro Entropia Relativa disponivel, em todas as
Updated treatment strategies for intestinal Behçet’s disease

Behçet’s disease (BD) is a chronic, idiopathic, relapsing immune-mediated disease involving multiple organs, and is characterized by recurrent oral and genital ulcers, ocular disease, gastrointestinal ulcers, vascular diseases, and skin lesions. In particular, gastrointestinal involvement in BD is followed by severe complications, including massive bleeding, bowel perforation, and fistula, which can lead to significant morbidity and mortality. However, the management of intestinal BD has not yet been properly established. Intestinal BD patients with a severe clinical course experience frequent disease aggravations and often require recurrent corticosteroid and/or immunomodulatory therapies, or even surgery. However, a considerable number of patients with intestinal BD are often refractory to conventional therapies such as corticosteroids and immunomodulators. Recently, there has been a line of evidence suggesting that biologics such as infliximab and adalimumab are effective in treating intestinal BD. Moreover, new biologics targeting proteins other than tumor necrosis factor α are emerging and are under active investigation. Therefore, in this paper, we review the current therapeutic strategies and new clinical data for the treatment of intestinal BD.