Miracle-dz/UniFAR-FTUs huggingface dataset:
[Differences in the course of depressive disorders among women and men measured by MMPI-2].

AIM The aim of the study is to assess the differences between clinical scales of MMPI-2 among women and men suffering from depressive disorders. METHOD 36 patients were examined (aged 23-62 years, average age = 51.27, SD = 8.84): 19 women (52.77%, aged 23-59, average age = 51.16, SD = 4.74) and 17 men (47.23%, aged: 23-61, average age = 51.41, SD = 12.07). All patients were hospitalised in the Clinic of Adult Psychiatry Medical University of Łódź. The Minnesota Multiphasic Personality Inventory (MMPI-2, adapted by T. Kucharski) and Hamilton Depression Rating Scale (HDRS, consisting of 21-items) were used. MMPI-2 is used in psychological diagnostic and HDRS is used to assess the intensity of depressive disorders. RESULTS Relevant statistical differences between women and men in the several clinical scales of MMPI-2 were observed. There were no relevant statistical differences between the examined groups in the HDRS. CONCLUSIONS (1). The characteristic symptoms of depressive disorders for women are: the excessive concentration on physical health, numerous complaints about physical disabilities, lack of energy, insomnia, diminishing of attention concentration and low self-esteem, diffidence and pessimism (2). Examined men achieved statistically lower results than women in the following scales: hypochondria, hysteria and D1, D3, D4 subscales of the depression scale. (3). MMPI-2 is one of the psychological methods which allow for a specific diagnosis of depressive disorders symptoms among women and men.
Just-in-Time Control of Spo0A Synthesis in Bacillus subtilis by Multiple Regulatory Mechanisms

ABSTRACT The response regulator Spo0A governs multiple developmental processes in Bacillus subtilis, including most conspicuously sporulation. Spo0A is activated by phosphorylation via a multicomponent phosphorelay. Previous work has shown that the Spo0A protein is not rate limiting for sporulation. Rather, Spo0A is present at high levels in growing cells, rapidly rising to yet higher levels under sporulation-inducing conditions, suggesting that synthesis of the response regulator is subject to a just-in-time control mechanism. Transcription of spo0A is governed by a promoter switching mechanism, involving a vegetative, σA-recognized promoter, Pv, and a sporulation σH-recognized promoter, Ps, that is under phosphorylated Spo0A (Spo0A∼P) control. The spo0A regulatory region also contains four (including one identified in the present work) conserved elements that conform to the consensus binding site for Spo0A∼P binding sites. These are herein designated O1, O2, O3, and O4 in reverse order of their proximity to the coding sequence. Here we report that O1 is responsible for repressing Pv during the transition to stationary phase, that O2 is responsible for repressing Ps during growth, that O3 is responsible for activating Ps at the start of sporulation, and that O4 is dispensable for promoter switching. We also report that Spo0A synthesis is subject to a posttranscriptional control mechanism such that translation of mRNAs originating from Pv is impeded due to RNA secondary structure whereas mRNAs originating from Ps are fully competent for protein synthesis. We propose that the opposing actions of O2 and O3 and the enhanced translatability of mRNAs originating from Ps create a highly sensitive, self-reinforcing switch that is responsible for producing a burst of Spo0A synthesis at the start of sporulation.
Effect of cocoa's theobromine on intestinal microbiota of rats.

SCOPE To establish the role of cocoa theobromine on gut microbiota composition and fermentation products after cocoa consumption in rats. METHODS AND RESULTS Lewis rats were fed either a standard diet (RF diet), a diet containing 10% cocoa (CC diet) or a diet including 0.25% theobromine (TB diet) for 15 days. Gut microbiota (fluorescence in situ hybridization coupled to flow cytometry and metagenomics analysis), SCFA and IgA-coated bacteria were analyzed in fecal samples. CC and TB diets induced lower counts of E. coli whereas TB diet led to lower counts of Bifidobacterium spp. , Streptococcus spp. and Clostridium histolyticum-C. perfingens group compared to RF diet. Metagenomics analysis also revealed a different microbiota pattern among the studied groups. The SCFA content was higher after both CC and TB diets, which was mainly due to enhanced butyric acid production. Furthermore, both diets decreased the proportion of IgA-coated bacteria. CONCLUSION Cocoa's theobromine plays a relevant role in some effects related to cocoa intake, such as the lower proportion of IgA-coated bacteria. Moreover, theobromine modifies gut microbiota although other cocoa compounds could also act on intestinal bacteria, attenuating or enhancing the theobromine effects.
A kind of wormhole attack defense strategy of WSN based on neighbor nodes verification

Wormhole is a kind of attack in Wireless Sensor Network (WSN) that needs not to crack encryption key, which has great harm. Aiming at characteristics of Wormhole attack, the paper presented a kind of wormhole attack defense strategy of WSN based on neighbor nodes verification. Under this strategy, when each normal node received control packet, it will monitor the packet to determine whether it comes from its normal neighbor nodes to avoid Wormhole attack effectively. Modeling and simulation of WSN based on OMNeT++ shows that the AODV added neighbor nodes verification successfully implement effective defense.
Design and Implementation of a Single-Stage Driver for Supplying an LED Street-Lighting Module With Power Factor Corrections

This paper proposes a novel single-stage light-emitting diode (LED) driver for street-lighting applications with power factor corrections (PFC). The presented driver integrates a modified bridgeless PFC ac-dc converter with a half-bridge-type LLC dc-dc resonant converter into a single-stage conversion circuit topology. The proposed ac-dc resonant driver provides input current shaping, and it offers attributes of lowered switching losses to the soft-switching functions obtained on two power switches and two output-rectifier diodes. The proposed driver features cost-effectiveness, high circuit efficiency (>92%), high power factor (>0.99) and low input current total harmonics distortion (<;8%). A prototype driver is developed for supplying a 144-W-rated LED street-lighting module with utility-line input voltages ranging from 100 to 120 V, and experimental results demonstrate the functionalities of the proposed LED driver.
Enhanced production of tissue inhibitor of metalloproteinases by peripheral blood mononuclear cells of rheumatoid arthritis patients responding to methotrexate treatment.

OBJECTIVE To determine the effects of methotrexate (MTX) treatment of rheumatoid arthritis (RA) patients (a) on the circulating levels and (b) on the ex vivo production of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1) by peripheral blood mononuclear cells (PBMNC). METHODS Circulating levels, spontaneous ex vivo and in vitro production of MMP-1, TIMP-1 and interleukin-6 (IL-6) were assessed by immunoassays in sera and culture supernatants of PBMNC derived from 27 patients with active RA before and 3 months after beginning MTX treatment and from seven healthy subjects. The production and serum levels of MMP-1, TIMP-1 and IL-6 were correlated to the clinical response. RESULTS PBMNC of RA patients showing >/= 20% improvement of the Paulus index after 3 months of MTX treatment (responders; n = 16) exhibited a significantly enhanced production of spontaneous TIMP-1 ex vivo which was associated with the enhanced synthesis of IL-6. In contrast, PBMNC of 11 patients with <20% improvement and/or progression of disease showed a marked reduction of TIMP-1 and IL-6 secretion. Circulating levels of TIMP-1 remained unchanged in both groups whereas serum IL-6 levels declined in the responder group. MMP-1 was detectable only in very few culture supernatants and RA sera. Moreover, PBMNC of healthy donors revealed that MTX also stimulated TIMP-1 and IL-6 release in vitro, IL-6 being partially responsible for the induction of TIMP-1 production. CONCLUSIONS Both ex vivo and in vitro, the enhanced TIMP-1 production by PBMNC of RA patients and healthy individuals upon MTX treatment is associated with simultaneously enhanced IL-6 release, and enhanced ex vivo production of both is clearly associated with short-term clinical efficacy. This may reflect disease remission and favourable effects on host defence mechanisms against aberrant inflammation and extracellular matrix turnover in RA patients undergoing MTX treatment.
SV40 enhancer activation during retinoic acid‐induced differentiation of F9 embryonal carcinoma cells.

The transient expression vector pSV2CAT, which carries the bacterial chloramphenicol acetyl transferase (CAT) gene under the control of the SV40 early promoter, was used to transfect the murine embryonal carcinoma cell line F9 at various times during the retinoic acid‐induced differentiation of these cells. Expression of the CAT gene under SV40 promoter control was found to increase markedly on F9 cell differentiation, measured relative to expression from the thymidine kinase promoter in the same cells. A series of constructs was prepared to identify the features of the SV40 early promoter required for transcription in differentiated and undifferentiated cells, as well as the factors limiting transcription in each case. The increased transcription seen on F9 cell differentiation was not observed when cells were transfected with molecules lacking a functional enhancer. It appears that as embryonal carcinoma cells differentiate, increased SV40 transcription results from enhancer sequence activation. In both differentiated and undifferentiated cell types the level of transcription was found to be limited by the availability and/or activity of cellular factors necessary for enhancer function.
Influence of composition on the performance of sintered Cu(In,Ga)Se2 nanocrystal thin-film photovoltaic devices.

Thin-film photovoltaic devices (PVs) were prepared by selenization using oleylamine-capped Cu(In,Ga)Se2 (CIGS) nanocrystals sintered at a high temperature (>500 °C) under Se vapor. The device performance varied significantly with [Ga]/[In+Ga] content in the nanocrystals. The highest power conversion efficiency (PCE) observed in the devices studied was 5.1 % under air mass 1.5 global (AM 1.5 G) illumination, obtained with [Ga]/[In+Ga]=0.32. The variation in PCE with composition is partly a result of bandgap tuning and optimization, but the main influence of nanocrystal composition appeared to be on the quality of the sintered films. The [Cu]/[In+Ga] content was found to be strongly influenced by the [Ga]/[In+Ga] concentration, which appears to be correlated with the morphology of the sintered film. For this reason, only small changes in the [Ga]/[In+Ga] content resulted in significant variations in device efficiency.
Full-Scale Experience with the Sharon Process through the Eyes of the Operators

This paper summarizes different operating aspects and experiences of several SHARON plants. The SHARON process is suitable for treatment of high strength ammonia wastewaters such as reject water from dewatering of digested sewage sludge and wastewater from sludge drying or incineration plants. The aerated retention time and nitrite concentration are the two most important process parameters to control the ammonia outlet concentration. Ammonia removal efficiencies can be over 95%, are variable and can be targeted according to the required needs of the main WWTP and/or to minimize overall nitrogen removal costs. The process is compact and simple to operate. Depending on site specific circumstances there are different system configurations possible. Nine years of operating experience prove that the SHARON process is sustainable and highly competitive. Compared to conventional techniques there are significant savings of energy and consumables. Application of fine bubble aeration has further decreased aeration costs. Recently the use of by-products of the biofuel industry as COD source for denitrification has further increased the cost effectiveness. SHARON is successfully applied to significantly improve the main WWTP nitrogen effluent quality. It proves to be a cost effective alternative for conventional extension of the WWTP.
[Anisodamine in prevention and treatment of sepsis of severely burned patients].

OBJECTIVE To observe the preventive effect of anisodamine on possible sepsis of patients with major burns and the effect of anisodamine on patients with sepsis. METHODS Forty-two patients with extensive burn admitted to our burn institute from April 1998 to November 1999 were divided randomly into two groups: treatment group (T group) and control group (C group). In the T group, all 20 patients received fluid resuscitation regimen with anisodamine, and in the C group, 22 patients received the regimen with no anisodamine. A tonometry catheter was positioned in the stomach, connecting with the automatic gas analysis machine (Datex-Engstrom Corporation, Dutch) for determining gastric intramucosal pH (pHi). The plasma concentrations of diamine oxidase (DAO) and endotoxin were measured. Correlation analysis between pHi, DAO and endotoxin were made respectively during early stage of postburn. All the parameters in 7 patients with sepsis before and after administration of anisodamine were compared with those in 6 patients with sepsis without use of anisodamine. RESULTS The incidence of sepsis in the T group was lower (20.0%) than that in C group (40.9%). The gastric pHi value in the early period of postburn was significantly higher in the T group than in the C group (P < 0.05). Concurrently, the plasma concentrations of DAO and endotoxin were significantly lower in the T group than in the C group (P < 0.05 or 0.01). A significant negative correlation was seen between the gastric pHi and respective values of DAO, endotoxin (P < 0.05 or 0.01). There were a decrease in gastric pHi, and an increase in plasma DAO and endotoxin level in patients with septic episode; however all the parameters after administration of anisodamine were improved compared with those in septic patients without use of anisodamine. CONCLUSIONS Intestinal ischemic injury plays an important role in provoking sepsis during early postburn period. Anisodamine is effective in restoring intestinal circulation both in the shock phase and after the development of sepsis.
The Problem of Not Developing Normally and Pediatric Neuropsychological Rehabilitation: The Mitchell Rosenthal Lecture

Children who suffer moderately severe-to-severe traumatic brain injury often fail to develop normal cognitive and affective functioning necessary for independent adult living. The cognitive and psychiatric consequences of pediatric traumatic brain injury are outlined and 6 barriers to providing neuropsychological rehabilitation for these children are identified. Suggestions are made to help reduce the impact of those barriers.
Basement membrane type IV collagen in oral squamous cell carcinoma

Biopsied specimens of 82 oral squamous cell carcinomas were immunohistochemically studied for detection of type IV collagen existence in the basement membrane (BM). Immunoreactivity on BM was semiquantitatively evaluated as limited (±), moderate (+), or extensive (++), and matched against clinical and histopathologic features. No clear difference in BM deposition could be found in the tumor sites. The amount of type IV collagen decreased in advanced T stage (T3 and T4) tumors. BM deposition was significantly correlated with lymph node metastasis. In 54 N‐, 32 had extensive deposition, 18 had moderate, and the remaining had limited. Conversely, only 5 of 28 N+ cases showed good type IV collagen immunoreactivity and 14 cases exhibited limited BM deposition. BM existence was also associated with the mode of invasion. BM deposition decreased in order with the grade (i.e., the more limited the BM deposition, the more diffuse the invasion mode). BM deposition was, however, not related with stromal responses, such as cellular infiltrates and fibrosis. We conclude that immunohistochemical examinations of BM deposition on biopsied specimens seem beneficial for cancer treatment.
Modulation of frontal lobe speech areas associated with the production and perception of speech movements.

PURPOSE It is unclear whether the production and perception of speech movements are subserved by the same brain networks. The purpose of this study was to investigate neural recruitment in cortical areas commonly associated with speech production during the production and visual perception of speech. METHOD This study utilized functional magnetic resonance imaging (fMRI) to assess brain function while participants either imitated or observed speech movements. RESULTS A common neural network was recruited by both tasks. The greatest frontal lobe activity in Broca's area was triggered not only when producing speech but also when watching speech movements. Relatively less activity was observed in the left anterior insula during both tasks. CONCLUSION These results support the emerging view that cortical areas involved in the execution of speech movements are also recruited in the perception of the same movements in other speakers.
Reduced Model for the Nonlinear Response of Reflective Semiconductor Optical Amplifiers

Reflective semiconductor optical amplifiers (RSOAs) became a key-technology for the implementation of next generation local area passive optical networks (PONs). In this letter, we present a semi-analytic study of their nonlinear dynamics, based on the derivation of a reduced model that gives the input-output RSOA transmission function as the solution of a standard differential equation. The reduced model is computationally more efficient than full-scale computer simulations of time-domain models, and can be used for a fully analytic study of four wave mixing in the context of WDM- and OFDM-based PONs.
ANÁLISE ENERGÉTICA DE BEBIDA MISTA DE EXTRATO HIDROSSOLÚVEL DE SOJA E

O objetivo deste estudo foi caracterizar energeticamente bebidas mistas de extrato hidrossoluvel de soja (EHS) e suco de amora, que foram desenvolvidas no Laboratorio de Bebidas, da Faculdade de Ciencias Agronomicas, UNESP, Campus de Botucatu. As materias-primas foram soja (variedade BRS 213), amora (genero Morus ), pectina citrica e acucar. A bebida mista foi fabricada em diferentes proporcoes de EHS e suco de amora (1:1; 1:1,5 e 1:2; respectivamente; m/m) e diferentes concentracoes de solidos soluveis (10, 12 e 14 °Brix). Os EHS, os sucos de amora e as bebidas mistas foram analisados quimicamente e a partir das analises quimicas os valores energeticos foram quantificados. Os valores energeticos dos EHS deste trabalho variaram entre 29,9 a 31,8 kcal 100 g -1 , os do suco de amora 29,9 a 33 kcal 100 g -1 . Ja, para as bebidas mistas, os valores energeticos variaram entre 41,60 a 60,50 kcal 100 g -1 , permitindo concluir que os teores de solidos soluveis das bebidas mistas produzidas guardam uma relacao direta com os valores energeticos das mesmas. Palavras-chave : Bebida nao alcoolica, leite de soja, valor energetico. ENERGY ANALYSIS OF MIXED DRINK OF SOYBEAN EXTRACT AND MULBERRY JUICE SUMMARY: The objective of this study was to characterize the energy of the mixed drinks with soybean extract and blueberry juice, wich were developed at Drinks Lab, at Faculdade Ciencias Agronomicas, UNESP, campus of Botucatu. The raw materials were soybeans (variety BRS 213), mulberry (genre Morus), citrus pectin and sugar. The mixed drink was made with different proportions of soymilk and mulberry juice (1:1, 1:1,5 and 1:2, respectively, m/m) and different concentrations of soluble solids (10, 12 and 14 °Brix). The soymilk, the mulberry juices and the mixed drinks were chemically analyzed, and from the chemistry analysis the energy values were quantified. The energy values of soybean extracts of this work ranged from 29,9 to 31,8 kcal 100 g -1 , the mulberry juice from 29,9 to 33 kcal 100 g -1 . Already, the energy values of the mixed drinks ranged from 41,60 to 60,50 kcal 100 g -1 , which was conclude that solid soluble content of the mixed drink has a direct relation with the energy value of it. Keywords: Non-alcoholic beverage, soymilk, energy.
Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase (*)

Platelet stimulation by thrombin or the thrombin receptor activating peptide (TRAP) results in the activation of phosphoinositide 3-kinase and the production of the novel polyphosphoinositides phosphatidylinositol 3,4-bisphosphate (PtdIns-3,4-P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns-3,4,5-P3). We have shown previously that these lipids activate calcium-independent protein kinase C (PKC) isoforms in vitro (Toker, A., Meyer, M., Reddy, K. K., Falck, J. R., Aneja, R., Aneja, S., Parra, A., Burns, D. J., Ballas, L. M. and Cantley, L. C.(1994) J. Biol. Chem. 269, 32358-32367). Activation of platelet PKC in response to TRAP is detected by the phosphorylation of the major PKC substrate in platelets, the p47 phosphoprotein, also known as pleckstrin. Here we provide evidence for two phases of pleckstrin phosphorylation in response to TRAP. A rapid phase of pleckstrin phosphorylation (<1 min) precedes the peak of PtdIns-3,4-P2 production and is unaffected by concentrations of wortmannin (10-100 nM) that block production of this lipid. However prolonged phosphorylation of pleckstrin (>2 min) is inhibited by wortmannin concentrations that block PtdIns-3,4-P2 production. Phorbol ester-mediated pleckstrin phosphorylation was not affected by wortmannin and wortmannin had no effect on purified platelet PKC activity. Phosphorylation of pleckstrin could be induced using permeabilized platelets supplied with exogenous -P[ATP] and synthetic dipalmitoyl PtdIns-3,4,5-P3 and dipalmitoyl PtdIns-3,4-P2 micelles, but not with dipalmitoyl phosphatidylinositol 3-phosphate or phosphatidylinositol 4,5-bisphosphate. These results suggest two modes of stimulating pleckstrin phosphorylation: a rapid activation of PKC (via diacylglycerol and calcium) followed by a slower activation of calcium-independent PKCs via PtdIns-3,4-P2.
Operationszustand versus Steuerzustand - eine äußerst zweckmäßige Unterscheidung

Die systemtheoretische Begrundung fur die Einfuhrung des Zustandsbegriffs findet man im Mosaik-stein "Der Zustandsbegriff in der Systemtheorie". Wahrend sich die dortige Betrachtung sowohl mitkontinuierlichen als auch mit diskreten Systemen befast, wird hier die Betrachtung auf diskrete Sy-steme beschrankt.
Determination of a natural valence-band offset: The case of HgTe-CdTe.

We propose a method to determine a natural valence-band offset (NVBO), i.e., the change in the valence-band maximum energy which is intrinsic to the bulk band structure of semiconductors. We use the Hg-Te-CdTe system as an example in which we find that the valence-band maximum of HgTe lies 0.35\ifmmode\pm\else\textpm\fi{}0.06 eV above that of CdTe. The NVBO of 0.35 eV is in good agreement with the x-ray photoemission spectroscopy measurement of the heterojunction offset. The procedure to determine the NVBO between semiconductors, and its implication of the heterojunction band line-up and the electronic structures of semiconductor alloys, are discussed.
An FFT-Based Full-Search Block Matching Algorithm with Sum of Squared Differences Criterion

An FFT-based full-search block matching algorithm (BMA) is described that uses the sum of squared differences (SSD) criterion. The proposed method does not have to extend a real signal into complex one. This reduces the computational load of FFT approaches. In addition, if two macroblocks share the same search window, they can be matched at the same time. In a simulation of motion estimation, the proposed method achieved the same performance as a direct SSD full search and its processing speed is faster than other FFT-based BMAs.