Miracle-dz/UniFAR-FTUs huggingface dataset:
Scheduling Continuous Operators for IoT Edge Analytics

In this paper we are interested in exploring the Edge-Fog-Cloud architecture as an alternative approach to the Cloud-based IoT data analytics. Given the limitations of Fog in terms of limited computational resources that can also be shared among multiple analytics with continuous operators over data streams, we introduce a holistic cost model that accounts both the network and computational resources available in the Edge-Fog-Cloud architecture. Then, we propose scheduling algorithms RCS and SOO-CPLEX for placing continuous operators for data stream analytics at the network edge. The former dynamically places continuous operators between the Cloud and the Fog according to the evolution of data streams rates and uses as less as possible Fog computational resources to satisfy the constraints regarding the usage of both computational and network resources. The latter statically places continuous operators between the Cloud and the Fog to minimize the overall computational and network resource usage cost. Based on thorough experiments, we evaluate the effectiveness of SOO-CPLEX and RCS using simulation.
OBFUS: An Obfuscation Tool for Software Copyright and Vulnerability Protection

In this paper, we propose OBFUS, a web-based tool that can easily apply obfuscation techniques to high-level and low-level programming languages. OBFUS's high-level obfuscator parses and obfuscates the source code, overlaying the obfuscation to produce more complex results. OBFUS's low-level obfuscator decompiles binary programs into LLVM IR. This LLVM IR pro-gram is obfuscated and the LLVM IR program is recompiled to become an obfuscated binary program.
Performance Impact Analysis of Securing MQTT Using TLS

The interconnectivity of devices on the Internet of Things (IoT) provides many new and smart applications. However, the integration of many devices - especially by inexperienced users - might introduce several security threats. Further, several often used communication protocols in the IoT domain are not out-of-the-boxsecured. On the other hand, security inherently introduces overhead, resulting in a decrease in performance. The Message QueuingTelemetry Transport (MQTT) protocol is a popular communication protocol for IoT applications - for example, in Industry 4.0, railways, automotive, or smart homes. This paper analyzes the influence on performance when using MQTT with TLS in terms of throughput, connection build-up times, and energy efficiency using a reproducible testbed based on a standard off-the-shelf microcontroller. The results indicate that the impact of TLS on performance across all QoS levels depends on (i) the network situation and (ii) the connection reestablishment frequency. Thus, a negative influence of TLS on the performance is noticeable only in deteriorated networksituations or at a high connection reestablishment frequency.
Array CRDTs Using Delta-Mutations

&dgr;-CRDTs can achieve the best of both worlds compared to operation and state based alternatives, enabling small incremental messages disseminated over unreliable communication channels. The main composable causal &dgr;-CRDT defined to date is an Observed-Remove Map which can embed other causal &dgr;-CRDTs. However, maps on their own are not sufficient to handle most real world scenarios. In this paper we construct nested &dgr;-based Array CRDTs with support for move operation. Arrays and maps can then be combined to represent many useful data types, notably JSON documents, which require (1) maps, (2) arrays, and (3) atoms, and allow arbitrary nesting. To achieve this we define two new algorithms for &dgr;-based array CRDTs, one with remove-wins semantics and the other with observed-remove semantics. While previous solutions exist for operations based CRDTs, we provide a &dgr;-CRDT based solution.
Trajectory Outlier Detection

This article introduces two new problems related to trajectory outlier detection: (1) group trajectory outlier (GTO) detection and (2) deviation point detection for both individual and group of trajectory outliers. Five algorithms are proposed for the first problem by adapting DBSCAN, k nearest neighbors (kNN), and feature selection (FS). DBSCAN-GTO first applies DBSCAN to derive the micro clusters, which are considered as potential candidates. A pruning strategy based on density computation measure is then suggested to find the group of trajectory outliers. kNN-GTO recursively derives the trajectory candidates from the individual trajectory outliers and prunes them based on their density. The overall process is repeated for all individual trajectory outliers. FS-GTO considers the set of individual trajectory outliers as the set of all features, while the FS process is used to retrieve the group of trajectory outliers. The proposed algorithms are improved by incorporating ensemble learning and high-performance computing during the detection process. Moreover, we propose a general two-phase-based algorithm for detecting the deviation points, as well as a version for graphic processing units implementation using sliding windows. Experiments on a real trajectory dataset have been carried out to demonstrate the performance of the proposed approaches. The results show that they can efficiently identify useful patterns represented by group of trajectory outliers, deviation points, and that they outperform the baseline group detection algorithms.
Synthesis, characterization, biological activities, and catalytic applications of alcoholic extract of saffron (Crocus sativus) flower stigma-based gold nanoparticles

Abstract Currently, nanotechnology is gaining massive attention compared to conventional methods as the biosynthesis of plant-based nanoparticles is considered safe, effective, and ecofriendly. Therefore, keeping in view the importance of nanotechnology, the present study was designed to synthesize, characterize, and evaluate the biological effectiveness of saffron stigma-based gold nanoparticles (SS-AuNPs) for their in vitro and in vivo biological properties. These gold nanoparticles were characterized by UV–Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD). The highest antibacterial effect was observed by the saffron extract against Escherichia coli (22 mm). SS-AuNPs significantly inhibited the activity of enzyme urease (54.98%) and CA-II (64.29%). However, the nonsignificant inhibitory effect was observed in the case of α-chymotrypsin. Maximum analgesic (84.98%) and antiinflammatory (88.98%) effects were observed for SS-AuNPs (10 mg/kg). Similarly, SS-AuNPs demonstrated a significant (P < 0.01) sedative effect at all tested doses.
Tumor Microenvironmental Competitive Endogenous RNA Network and Immune Cells Act as Robust Prognostic Predictor of Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is malignant hematologic tumors with frequent recurrence and cause high mortality. Its fate is determined by abnormal intracellular competitive endogenous RNA (ceRNA) network and extracellular tumor microenvironment (TME). This study aims to build a ceRNA network related to AML TME to explore new prognostic and therapeutic targets. The RNA expression data of AML were obtained from The Cancer Genome Atlas (TCGA) database. First, we used the ESTIMATE algorithm to calculate the immune cells and stromal cells infiltration scores in the TME and found that all scores were highly correlated with AML’s prognostic characteristics. Subsequently, differentially expressed mRNAs and lncRNAs between high and low score groups were identified to construct a TME-related ceRNA network. Further, the Cox-lasso survival model was employed to screen out the hub prognostic ceRNA network composed of two mRNAs (EPB41L3, COL2A1), three miRNAs (hsa-mir-26a-5p, hsa-mir-148b-3p, hsa-mir-148a-3p), and two lncRNAs (CYP1B1-AS1, C9orf106), and construct nomograms. Finally, we used CIBERSORT algorithm and Kaplan-Meier survival analysis to identify the prognostic TME immune cells and found that naive B cells, M2-type macrophages, and helper follicular T cells were related to prognosis, and the hub ceRNAs were highly correlated with immune cell infiltration. This study provided a new perspective to elucidate how TME regulates AML process and put forward the new therapy strategies combining targeting tumor cells with disintegrating TME.
Genetic Relationships Among Physiological Processes, Phenology, and Grain Yield Offer an Insight Into the Development of New Cultivars in Soybean (Glycine max L. Merr)

Soybean grain yield has steadily increased during the last century because of enhanced cultivars and better agronomic practices. Increases in the total biomass, shorter cultivars, late maturity, and extended seed-filling period are frequently reported as main contributors for better soybean performance. However, there are still processes associated with crop physiology to be improved. From the theoretical standpoint, yield is the product of efficiency of light interception (Ei), radiation use efficiency (RUE), and harvest index (HI). The relative contribution of these three parameters on the final grain yield (GY), their interrelation with other phenological–physiological traits, and their environmental stability have not been well established for soybean. In this study, we determined the additive–genetic relationship among 14 physiological and phenological traits including photosynthesis (A) and intrinsic water use efficiency (iWUE) in a panel of 383 soybean recombinant inbred lines (RILs) through direct (path analyses) and indirect learning methods [least absolute shrinkage and selection operator (LASSO) algorithm]. We evaluated the stability of Ei, RUE, and HI through the slope from the Finley and Wilkinson joint regression and the genetic correlation between traits evaluated in different environments. Results indicate that both supervised and unsupervised methods effectively establish the main relationships underlying changes in Ei, RUE, HI, and GY. Variations in the average growth rate of canopy coverage for the first 40 days after planting (AGR40) explain most of the changes in Ei. RUE is primarily influenced by phenological traits of reproductive length (RL) and seed-filling (SFL) as well as iWUE, light extinction coefficient (K), and A. HI showed a strong relationship with A, AGR40, SFL, and RL. According to the path analysis, an increase in one standard unit of HI promotes changes in 0.5 standard units of GY, while changes in the same standard unit of RUE and Ei produce increases on GY of 0.20 and 0.19 standard units, respectively. RUE, Ei, and HI exhibited better environmental stability than GY, although changes associated with year and location showed a moderate effect in Ei and RUE, respectively. This study brings insight into a group of traits involving A, iWUE, and RL to be prioritized during the breeding process for high-yielding cultivars.
Using Unmanned Aerial Vehicle and Ground-Based RGB Indices to Assess Agronomic Performance of Wheat Landraces and Cultivars in a Mediterranean-Type Environment

The adaptability and stability of new bread wheat cultivars that can be successfully grown in rainfed conditions are of paramount importance. Plant improvement can be boosted using effective high-throughput phenotyping tools in dry areas of the Mediterranean basin, where drought and heat stress are expected to increase yield instability. Remote sensing has been of growing interest in breeding programs since it is a cost-effective technology useful for assessing the canopy structure as well as the physiological traits of large genotype collections. The purpose of this study was to evaluate the use of a 4-band multispectral camera on-board an unmanned aerial vehicle (UAV) and ground-based RGB imagery to predict agronomic traits as well as quantify the best estimation of leaf area index (LAI) in rainfed conditions. A collection of 365 bread wheat genotypes, including 181 Mediterranean landraces and 184 modern cultivars, was evaluated during two consecutive growing seasons. Several vegetation indices (VI) derived from multispectral UAV and ground-based RGB images were calculated at different image acquisition dates of the crop cycle. The modified triangular vegetation index (MTVI2) proved to have a good accuracy to estimate LAI (R2 = 0.61). Although the stepwise multiple regression analysis showed that grain yield and number of grains per square meter (NGm2) were the agronomic traits most suitable to be predicted, the R2 were low due to field trials were conducted under rainfed conditions. Moreover, the prediction of agronomic traits was slightly better with ground-based RGB VI rather than with UAV multispectral VIs. NDVI and GNDVI, from multispectral images, were present in most of the prediction equations. Repeated measurements confirmed that the ability of VIs to predict yield depends on the range of phenotypic data. The current study highlights the potential use of VI and RGB images as an efficient tool for high-throughput phenotyping under rainfed Mediterranean conditions.
Assessing the Effect of Drought on Winter Wheat Growth Using Unmanned Aerial System (UAS)-Based Phenotyping

Drought significantly limits wheat productivity across the temporal and spatial domains. Unmanned Aerial Systems (UAS) has become an indispensable tool to collect refined spatial and high temporal resolution imagery data. A 2-year field study was conducted in 2018 and 2019 to determine the temporal effects of drought on canopy growth of winter wheat. Weekly UAS data were collected using red, green, and blue (RGB) and multispectral (MS) sensors over a yield trial consisting of 22 winter wheat cultivars in both irrigated and dryland environments. Raw-images were processed to compute canopy features such as canopy cover (CC) and canopy height (CH), and vegetation indices (VIs) such as Normalized Difference Vegetation Index (NDVI), Excess Green Index (ExG), and Normalized Difference Red-edge Index (NDRE). The drought was more severe in 2018 than in 2019 and the effects of growth differences across years and irrigation levels were visible in the UAS measurements. CC, CH, and VIs, measured during grain filling, were positively correlated with grain yield (r = 0.4–0.7, p < 0.05) in the dryland in both years. Yield was positively correlated with VIs in 2018 (r = 0.45–0.55, p < 0.05) in the irrigated environment, but the correlations were non-significant in 2019 (r = 0.1 to −0.4), except for CH. The study shows that high-throughput UAS data can be used to monitor the drought effects on wheat growth and productivity across the temporal and spatial domains.
Preliminary Qualitative and Quantitative Evaluation of DESIREE, a Decision Support Platform for the Management of Primary Breast Cancer Patients

The DESIREE project has developed a platform offering several complementary therapeutic decision support systems (DSSs) to improve care quality for breast cancer patients. A first assessment of the system was carried out in close-to-real tumor boards (TBs). Fourteen TB sessions were organized corresponding to a total of 125 exploitable decisions previously made without the system and re-played with the system after a washout period in three pilot sites. Results show an overestimation of declared compliance with guidelines when not using the system as compared to measured compliance with the recommendations issued from the guideline-based DSS of DESIREE. After using the system, measured compliance rate of decisions with guidelines was significantly improved from 74.4% to 89.6%. Most of the changes in decisions when using the guideline-based DSS were associated with non-compliant decisions that became compliant. Qualitative analysis and interviews showed that despite maturity issues, clinicians found DESIREE DSSs innovative and promising.
Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community

Objective Our aim was to prospectively assess the antibiotic resistance rates in Helicobacter pylori strains in Europe in 2018 and to study the link between antibiotic consumption in the community and H. pylori resistance levels in the different countries. Design The proportion of primary antibiotic resistance cases of H. pylori and their corresponding risk factors were investigated in 24 centres from 18 European countries according to a standardised protocol. Data on antibiotic consumption in the community were collected for the period 2008–2017. The link between antibiotic consumption and resistance data was assessed using generalised linear mixed models. The model with the best fit was selected by means of the Akaike Information Criterion. Results H. pylori resistance rates for the 1211 adult patients included were 21.4% for clarithromycin, 15.8% for levofloxacin and 38.9% for metronidazole and were significantly higher in Central/Western and Southern than in the Northern European countries. The best model fit was obtained for the Poisson distribution using 2013 consumption data. A signiﬁcant association was found between H. pylori clarithromycin resistance and consumption in the community of macrolides (p=0.0003) and intermediate-acting macrolides (p=0.005), and between levoﬂoxacin resistance and consumption of quinolones (p=0.0002) and second-generation quinolones (p=0.0003). Conclusion This study confirms the positive correlation between macrolide and quinolone consumption in the community and corresponding H. pylori resistance in European countries. Hence, H. pylori treatment with clarithromycin and levofloxacin should not be started without susceptibility testing in most European countries.
A Novel Framework Based on Mask R-CNN and Histogram Thresholding for Scalable Segmentation of New and Old Rural Buildings

Mapping new and old buildings are of great significance for understanding socio-economic development in rural areas. In recent years, deep neural networks have achieved remarkable building segmentation results in high-resolution remote sensing images. However, the scarce training data and the varying geographical environments have posed challenges for scalable building segmentation. This study proposes a novel framework based on Mask R-CNN, named Histogram Thresholding Mask Region-Based Convolutional Neural Network (HTMask R-CNN), to extract new and old rural buildings even when the label is scarce. The framework adopts the result of single-object instance segmentation from the orthodox Mask R-CNN. Further, it classifies the rural buildings into new and old ones based on a dynamic grayscale threshold inferred from the result of a two-object instance segmentation task where training data is scarce. We found that the framework can extract more buildings and achieve a much higher mean Average Precision (mAP) than the orthodox Mask R-CNN model. We tested the novel framework’s performance with increasing training data and found that it converged even when the training samples were limited. This framework’s main contribution is to allow scalable segmentation by using significantly fewer training samples than traditional machine learning practices. That makes mapping China’s new and old rural buildings viable.
Continuous Particle Swarm Optimization-Based Deep Learning Architecture Search for Hyperspectral Image Classification

Deep convolutional neural networks (CNNs) are widely used in hyperspectral image (HSI) classification. However, the most successful CNN architectures are handcrafted, which need professional knowledge and consume a very significant amount of time. To automatically design cell-based CNN architectures for HSI classification, we propose an efficient continuous evolutionary method, named CPSO-Net, which can dramatically accelerate optimal architecture generation by the optimization of weight-sharing parameters. First, a SuperNet with all candidate operations is maintained to share the parameters for all individuals and optimized by collecting the gradients of all individuals in the population. Second, a novel direct encoding strategy is devised to encode architectures into particles, which inherit the parameters from the SuperNet. Then, particle swarm optimization is used to search for the optimal deep architecture from the particle swarm. Furthermore, experiments with limited training samples based on four widely used biased and unbiased hyperspectral datasets showed that our proposed method achieves good performance comparable to the state-of-the-art HSI classification methods.
Analysis and Validation of a Hybrid Forward-Looking Down-Looking Ground Penetrating Radar Architecture

Ground Penetrating Radar (GPR) has proved to be a successful technique for the detection of landmines and Improvised Explosive Devices (IEDs) buried in the ground. In the last years, novel architectures for safe and fast detection, such as those based on GPR systems onboard Unmanned Aerial Vehicles (UAVs), have been proposed. Furthermore, improvements in GPR hardware and signal processing techniques have resulted in a more efficient detection. This contribution presents an experimental validation of a hybrid Forward-Looking–Down-Looking GPR architecture. The main goal of this architecture is to combine advantages of both GPR architectures: reduction of clutter coming from the ground surface in the case of Forward-Looking GPR (FLGPR), and greater dynamic range in the case of Down-Looking GPR (DLGPR). Compact radar modules working in the lower SHF frequency band have been used for the validation of the hybrid architecture, which involved realistic targets.
An Evaluation of the Effects of UAS Flight Parameters on Digital Aerial Photogrammetry Processing and Dense-Cloud Production Quality in a Scots Pine Forest

The application of unmanned aerial systems (UAS) in forest research includes a wide range of equipment, systems, and flight settings, creating a need for enhancing data acquisition efficiency and quality. Thus, we assessed the effects of flying altitude and lateral and longitudinal overlaps on digital aerial photogrammetry (DAP) processing and the ability of its products to provide point clouds for forestry inventory. For this, we used 18 combinations of flight settings for data acquisition, and a nationwide airborne laser scanning (ALS) dataset as reference data. Linear regression was applied for modeling DAP quality indicators and model fitting quality as the function of flight settings; equivalence tests compared DAPand ALS-products. Most of DAP-Digital Terrain Models (DTM) showed a moderate to high agreement (R2 > 0.70) when fitted to ALS-based models; nine models had a regression slope within the 1% region of equivalence. The best DAP-Canopy Height Model (CHM) was generated using ALS-DTM with an R2 = 0.42 when compared with ALS-CHM, indicating reduced similarity. Altogether, our results suggest that the optimal combination of flight settings should include a 90% lateral overlap, a 70% longitudinal overlap, and a minimum altitude of 120 m above ground level, independent of the availability of an ALS-derived DTM for height normalization. We also provided insights into the effects of flight settings on DAP outputs for future applications in similar forest stands, emphasizing the benefits of overlaps for comprehensive scene reconstruction and altitude for canopy surface detection.