Miracle-dz/UniFAR-FTUs huggingface dataset:
Bortezomib ADDED to R-CVP is safe and effective for previously untreated advanced-stage follicular lymphoma: a phase II study by the National Cancer Institute of Canada Clinical Trials Group.

PURPOSE Bortezomib has demonstrated promising activity in patients with follicular lymphoma (FL). This is the first study to evaluate the safety and efficacy of bortezomib added to rituximab, cyclophosphamide, vincristine, and prednisone (R-CVP) in previously untreated advanced-stage FL. PATIENTS AND METHODS This is a phase II multicenter trial adding bortezomib (1.3 mg/m(2) days 1 and 8) to standard-dose R-CVP (BR-CVP) for up to eight cycles in patients with newly diagnosed stage III/IV FL requiring therapy. Two co-primary end points, complete response rate (complete response [CR]/CR unconfirmed [CRu]) and incidence of grade 3 or 4 neurotoxicity, were assessed. RESULTS Between December 2006 and March 2009, 94 patients were treated with BR-CVP. Median patient age was 57 years (range, 29 to 84 years), and the majority had a high (47%) or intermediate (43%) Follicular Lymphoma International Prognostic Index score. BR-CVP was extremely well tolerated, with 90% of patients completing the intended eight cycles. No patients developed grade 4 neurotoxicity, and only five of 94 patients (5%; 95% CI, 0.8% to 9.9%) developed grade 3 neurotoxicity, which was largely reversible. On the basis of an intention-to-treat analysis, 46 of 94 patients (49%; 95% CI, 38.8% to 59.0%) achieved a CR/CRu, and 32 of 94 patients (34%) achieved a partial response, for an overall response rate of 83% (95% CI, 75.4% to 90.6%). CONCLUSION The addition of bortezomib to standard-dose R-CVP for advanced-stage FL is feasible and well tolerated with minimal additional toxicity. The complete response rate in this high-risk population compares favorably to historical results of patients receiving R-CVP. Given these results, a phase III trial comparing BR-CVP with R-CVP is planned.
06-Direct and Deliberative Democracy : The Question of Legitimacy HYBRID PARTICIPATORY BUDGETING : THE CHALLENGES OF A MULTI-CHANNEL PARTICIPATION 1

Over the past 25 years in many European democracies took place a bloom of experiments of Democratic Innovation (DI) and the development of tools for active involvement of citizens and their organizations in public policy-making processes (Allegretti, 2010). Institutions, Civil Society organizations, researchers and professionals have been involved in a complex activity of design and implementation of participatory procedures, with a special attention on territorial development issues: Participatory Budgets, Participatory Planning, Participation to Strategic Environmental Assessment (SEA), Agenda 21, Scenario Workshops, etc.
TIPS FOR CONTROLLING PORTAL HYPERTENSION COMPLICATIONS : EFFICACY , PREDICTORS OF OUTCOME AND TECHNICAL VARIATIONS *

OBJECTIVE: To evaluate the efficacy of TIPS (transjugular intrahepatic portosystemic shunt) for resolving clinical complications in patients with portal hypertension. MATERIALS AND METHODS: Forty-four caucasian patients, 30 men and 14 women, with a mean age of 52 years have been evaluated. Indication for TIPS has been gastrointestinal hemorrhage in 28 patients, and refractory ascites in 16. There has been 7 Child-Pugh A patients, 24 Child-Pugh B, and 11 Child-Pugh C. RESULTS: TIPS was successfully performed in all the patients (100%), with a decrease in the mean portosystemic pressure gradient of about 49.69% (from 18.98 mmHg to 9.55 mmHg). A clinical improvement was observed in 35 patients (79.55%). The general postoperative mortality rate was 13.64%, with higher incidence in Child-Pugh C patients (45.45%). The most relevant factors associated with a poor prognosis were increase in bilirubin and creatinine seric levels. The mean survival time was 11.5 months for Child-Pugh A patients, 10.97 months for Child-Pugh B patients, and just 5.9 months for Child-Pugh C patients. Complications directly related to the procedure have been observed in nine cases (20.44%). CONCLUSION: TIPS is efficient to reduce portosystemic pressure. TIPS-related complications and morbidity-mortality may be considered as acceptable. In the present study, mortality has been directly influenced by some clinical factors such as Child-Pugh class C, and increased bilirubin and creatinin seric levels.
A planar 8-port MIMO antenna for 2.4-GHz WLAN applications

A planar 8-port MIMO antenna consisting of only 4 slot elements is proposed in this paper. The antenna has a symmetrical structure and is designed to operate from 2.40–2.48 GHz. Each of the 4 slot elements is serving as a common radiator for 2 input ports. A T-shaped defected ground structure (DGS) is cut in the middle of the slot element to increase isolation between the two input ports to more than 10 dB and reduce the Envelop-Correlation Coefficient (ECC) to below 0.1. The proposed antenna is studied using computer simulation and fabricated for measurement using the Satimo Starlab system.
Pneumococcal meningitis in Iran: a systematic review and meta–analysis

Objective: To estimate the frequency of pneumococcal meningitis among patients with bacterial meningitis in Iran. Methods: PubMed, Embase, Web of Science and Scientific Information Database (www.sid.ir) were searched from 2000 to 2016 to identify studies on the frequency or prevalence of pneumococcal meningitis in Iran. Stata 14.0 (StataCorp, College Station, Texas, USA) was used to analyze the data. Results: Of the 131 records identified from the databases, 21 studies fulfilled the eligibility criteria. The analyses showed that 25.0% (95% CI: 19.0-32.0; I2=71%) of the confirmed bacterial meningitis (including children and adults) cases were caused by pneumococcus. Conclusions: The large fraction of meningitis cases caused by pneumococcus demonstrates that pneumococcal meningitis is a major public health problem in Iran, and the introduction of pneumococcal vaccines merits further attention from health authorities.
O Impacto da Avaliação de Acessibilidade em Estudos de Larga Escala sobre a Usabilidade Universal da Web

Resumo Este artigo apresenta um método de modelação, Ambientes de Interacção na Web, que permite exprimir as semelhanças e diferenças entre audiências para o estudo da usabilidade universal da Web. Com base neste método, definimos o modelo implı́cito da WCAG e estudámos o seu impacto na avaliação da acessibilidade na Wikipédia em larga escala. Descobrimos que os mecanismos de edição padronizada como os usados na Wikipédia reduzem o esforço de produzir conteúdos acessı́veis, mas não garantem que as ligações para sı́tios externos mantenham o mesmo nı́vel de acessibilidade. Por fim, discutimos a natureza de caixa negra de recomendações como a WCAG e como a formalização de audiências pode ajudar no estudo da usabilidade universal da Web em larga escala.
Self-Assessment and Quality Awards Models : a review of practice and process

It is emphasized that self-assessment practices using quality award-based models has been adopted by companies throughout the world as a comprehensive and systematic means for improvement. National Quality Award (NQA) models around the world have been developed to assist organizations for analyzing its performance with reference to quality management. In this paper the authors discuss the selfassessment practices based on NQA models on the basis of current literature. A range of issues is discussed including the main purpose, benefits and process of self-assessment practices. The main quality award-based world-renowned models and frameworks are also reviewed in this paper. This study is also highlighted the main benefits of self-assessment practices for organizations seeking to introduce quality management. The results can be considered as valuable information for management review to develop an effective action plan to better-performing companies by analyzing their current practice in their quest to put meaning to quality.
cdma2000 1/spl times/EV-DO forward link throughput sensitivity to diversity antenna correlation

This paper addresses the effects of the fade correlation between the receiver antennas of an access terminal (AT) on the forward link sector capacity of a cdma2000 1/spl times/EV-DO system. Traditionally, high fade correlation has been considered to be a significant source of capacity degradation for fixed rate wireless data/voice modems due to the lack of diversity and hence the increased variance of the received signal power which results in an increased fade margin or power control set point. The 1/spl times/EV-DO system, due to its advanced link adaptation, variable rate control, and multiuser diversity mechanisms, possesses inherent robustness towards such a lack of diversity. This point is demonstrated in this paper by network level simulations as well as by field data.
Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane

We report here the application of a previously described method to directly determine the CO2 permeability (PCO2) of the cell membranes of normal human red blood cells (RBCs) vs. those deficient in aquaporin 1 (AQP1), as well as AQP1‐expressing Xenopus laevis oocytes. This method measures the exchange of 18O between CO2, HCO3–, and H2O in cell suspensions. In addition, we measure the alkaline surface pH (pHS) transients caused by the dominant effect of entry of CO2 vs. HCO3– into oocytes exposed to step increases in [CO2]. We report that 1) AQP1 constitutes the major pathway for molecular CO2 in human RBCs; lack of AQP1 reduces PCO2 from the normal value of 0.15 ± 0.08 (SD; n85) cm/s by 60% to 0.06 cm/s. Expression of AQP1 in oocytes increases PCO2 2‐fold and doubles the alkaline pHS gradient. 2) pCMBS, an inhibitor of the AQP1 water channel, reduces PCO2 of RBCs solely by action on AQP1 as it has no effect in AQP1‐deficient RBCs. 3) PCO2 determinations of RBCs and pHS measurements of oocytes indicate that DIDS inhibits the CO2 pathway of AQP1 by half. 4) RBCs have at least one other DIDS‐sensitive pathway for CO2. We conclude that AQP1 is responsible for 60% of the high PCO2 of red cells and that another, so far unidentified, CO2 pathway is present in this membrane that may account for at least 30% of total PCO2. —Endeward, V. , Musa‐Aziz, R. , Cooper, G. J., Chen, L. , Pelletier, M. F. , Virkki, L. V. , Supuran, C. T. , King, L. S. , Boron, W. F. , Gros, G. Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane. FASEB J. 20, 1974–1981 (2006)
Adaptive Lighting for Knowledge Work Environments - A Pilot Design

Adaptive lighting technologies and control of lighting by users provide new possibilities for lighting design in the context of knowledge work environments. In our research project, we study innovation supporting knowledge work environments and their features, such as lighting. In this paper, we present and reflect the design of a pilot intervention, where the use of adaptive lighting was tested. We discuss how different forms of data and knowledge can be applied as a rationale for adaptive lighting behaviour which as an ambient feature in office environment supports knowledge workers` well-being and supports different working situations. In addition, we present the data-based evaluation methods with which we could gain feedback from users' experiences and their way of using the lighting and the pilot office environment. The potential of this kind of real-world data for future design processes is discussed.
Achieving Quality By Design Part I : Best Practices and Industry Challenges

I used to shoot people for a living. That experience gave me valuable insight into developing quality software. Before you call America's Most Wanted to turn me in, let me explain. Years ago I was a mechanical design engineer working on non-lethal weapons systems. One weapon I helped design was a perimeterweighted net that could be fired as a ballistic projectile at a subject from a shotgun mount. The purpose was to restrain but not harm the target. As part of our field testing, I would take some fellow engineers out into a field and "shoot" gun mounted canisters containing these nets at them, and then we would see if they could escape.
A hybrid mode-matching finite-elements approach to the analysis of thick dichroic screens with arbitrarily shaped apertures

A hybrid mode-matching (MM) finite-elements (FE) technique for the rigorous analysis of thick-screen inductive frequency selective surfaces (FSSs) is presented. The proposed hybrid approach combines the computational efficiency of the MM analysis with the versatility and flexibility of the FE method, enabling us to accurately model the electromagnetic behavior of inductive dichroic screens. These latter are realized by periodically perforating thick metallic screens with arbitrarily shaped apertures. The electromagnetic fields in the free-space region are expanded through a complete set of Floquet modes allowing us to reduce the analysis to the single periodicity cell; a set of waveguide modes is used inside the openings, each mode is numerically determined through an FE method procedure that relies on edge elements. A spectral criterion to determine the correct ratio between the number of waveguide and Floquet modes is adopted. Samples of numerical results are shown in order to check both the effectiveness and the accuracy of the proposed procedure.
Study on the growth traits in eighth-month beans ( Vigna unguiculata L . )

Eighth-month bean is a variant form of cowpea [Vigna unguiculata (L.) Walp] and is an important component in sacrifice ceremonies in Taiwanese Plains Aboriginal culture. Among the different colors of eighth-month bean, purplish pods contain a relatively high content of anthocyanins and are rich in nutrients. However, the seed phenotype of eighthmonth bean varies, and currently, little is known about the association of seeds with plant phenotypes and that of plant phenotypes with pod colors. This study distinguished the external appearance of seeds into three different types: brown seeds, seeds with variegated markings, and black seeds; this study also investigated the leaves, flower color, flowering time, pod color, pod length, weight of single pods, and number of seeds in plants grown from the different types of seeds. The results showed that plants grown from brown seeds had deep-green leaves with obvious leaf veins, light-purple flowers, and seed pods with six different colors (deep purple, light purple, purplish green, white, light green, and deep green). Among these, light-green and deep-green seed pods were the longest at approximately 29 cm, while white pods were the shortest at approximately 21 cm. The heaviest single pod weight (17.5 g) and the largest average number of seeds (16.7) were found in deep-green pods. Plants grown from seeds with variegated markings had light-green leaves, deep-purple flowers, and light-green and light-purple pods. The light-green pods were the longest (29.7 cm), heaviest (16.2 g), and with the most number of seeds (17.3). Plants grown from black seeds had light-green leaves with non-obvious veins, white flowers, and deep-green seeds and had a pod length of 30.6 cm, a pod weight of 15.2 g, and an average number of 18.7 seeds. The test for determining the anthocyanin content showed that anthocyanin was undetectable in plants with green leaves or green pods and that it could only be detected in plants with purple or white pods.
Cognitive Design Computing

This talk describes the foundational concepts of cognitive design computing and then presents some examples. Cognitive computing is concerned with modeling human cognition computationally and using that model as the foundation for constructing computer models of design activities. Human cognition is based on perception, learning and adaptation. Here we present human cognition in terms of situated cognition cognition involving interaction with an environment. The talk briefly introduces a set of principles for cognitive design computing founded on the three concepts of interaction, constructive memory and situatedness. It then presents two examples of applications of this approach.
Friction Compensation in the Inverted Pendulum Controller by Means of a Neural Network

Abstract This paper presents an experimental confirmation of the novel method of friction modelling and compensation. The method has been applied to an inverted pendulum control system. The practical procedure of data acquisition and processing has been described. Training of the neural network friction model has been covered. Application of the obtained model has been presented. The main asset of the presented model is its correctness in a wide range of relative velocities. Moreover, the model is relatively easy to build.
Non-digestible Oligosaccharides with Prebiotic Properties

The search for functional foods or functional food ingredients, i.e. foods or food ingredients that can enhance health, is beyond any doubt one of the leading trends in today's food industry. In this context, probiotics, i.e. living microbial food supplements, and prebiotics, i.e. non-digestible food ingredients, receive much attention. Both popular concepts target the gastrointestinal microbiota. While in the Western world, intake of probiotics has been recommended for long, prebiotics in general, and non-digestible oligosaccharides in particular, have only recently received attention. This review deals with production and characterization of non-digestible oligosaccharides and focuses on their role in promoting health and treating diseases. Attention is paid to the effects of non-digestible oligosaccharides on constipation, mineral absorption, lipid metabolism, cancer prevention, hepatic encephalopathy, glycemia/insulinemia, and immunomodulation.
The expression of nuclear retinoid receptors in human implantation.

Vitamin A and retinoids play an important role during development. They affect morphogenesis, cell growth and differentiation by interacting with two types of receptor, the RARs and the RXRs. Despite the well known established teratogenic effects of retinoids during human pregnancy, little is known about the effect of retinoids on human placental development. We studied the possible involvement of retinoids during the implantation process by investigating the spatial distribution of retinoid receptors in the human implantation site by in situ hybridization and immunohistochemistry. For in situ hybridization, we used digoxigenin-labelled antisense riboprobes. Immunochemical staining was performed with specific antibodies against the various retinoid receptors and a streptavidin-alkaline phosphatase immunostaining kit. We found that only two types of receptors were expressed at the implantation site: RARalpha and RXRalpha. Both types of receptors were present in the proliferative intermediate trophoblast, the invasive extravillous trophoblast and decidual cells. Both receptors were also present in the villous cytotrophoblasts. The presence of this retinoid receptor in the cytotrophoblasts suggests a key role for all-trans retinoic acid and/or 9-cis retinoic acid in the development of human placenta.
ACO based test case prioritization for fault detection in maintenance phase

The regression testing in maintenance phase is costly and time consuming phase of software development life cycle (SDLC). The cost of testing in maintenance phase has almost eighty percent of the total cost. The testing is performed in maintenance phase is called regression testing. The regression testing is unavoidable maintenance activity that is performed several times in SLDC. Therefore, optimization of regression testing like test case prioritization is highly required for reducing the testing time in maintenance phase. The two popular techniques for optimization of testing techniques are test case selection and test case prioritization. These techniques have integrated with different soft computing algorithms for getting fruitful regression test cases for making test suites. In this paper test case with prioritize order using modified ant colony optimization (ACO) is used better results. ACO will find the best test cases that have find the maximum fault in minimum time. The proposed approach has validated with benchmark example. The result shows the effective test case has selected with high APFD score. Keyword: Regression Testing, Maintenance Phase, ACO, APFD, Test Case, Test case prioritization
Gene expression profiling in human age-related nuclear cataract.

PURPOSE To identify genes that are differentially expressed in age-related nuclear cataracts compared to transparent human lenses. METHODS Total RNA was extracted from pools of central 5 mm capsulorrhexis epithelial samples microdissected at surgery from eyes with nuclear cataract or from age-matched transparent lenses (post-mortem). mRNA levels in the two samples were compared by hybridization to DNA microarrays (GeneFilter GF211) containing 4,132 known human genes. Only mRNAs consistently modulated over four comparisons were retained for analysis. A subset of the mRNA expression differences thus identified were verified and confirmed by Real-Time RT-PCR. Expressed and modulated genes were categorized according to the Gene Ontology classification. RESULTS The data revealed 262 genes that are downregulated and 7 that are upregulated by a factor of 2.5 or more in epithelial samples from cataractous lenses compared with transparent lenses. The highest content of downregulated genes was found in the functional classes "Signal transduction", "Regulation of cell proliferation", and "Protein modification". The "Response to oxidative stress" class was one of the least modulated. Among downregulated genes, we found several mRNAs coding for transcription/translation-related proteins, heat shock proteins 70 and 27, two ubiquitin-conjugating enzymes, two subunits of the cytoskeletal/chaperone protein, tubulin, betaA4-crystallin, and a group of Alzheimer-related proteins, including presenilin 1 and presenilin 2. CONCLUSIONS An extensive mRNA downregulation accompanies the development of the nuclear type of human age-related cataract. A few genes and classes of genes more prominently displaying this type of response have been identified. Altogether, the data indicate the tendency, in age-related nuclear cataract, towards a shutdown of de novo RNA and protein biosynthesis rather than an upregulation of cell defense components such as chaperones and various kinds of antioxidative or detoxifying proteins.
Tóth The imperative and the subjunctive proper in Hungarian 1

The paper examines Hungarian complement clauses where two morphologically identical moods in Hungarian, the subjunctive proper and/or the imperative may be used, including comparison of minimal pairs of contexts, where both are grammatical. It presents a case study and its statistical analysis aimed at characterising the grammatical and semantic role of the moods in question. On the basis of the empirical study it is suggested that independent semantic factors also support the claim that these moods need to be handled separately.
A Ranking-Based Evolutionary Algorithm for Constrained Optimization Problems

In constrained optimization problems, evolutionary algorithms often utilize a penalty function to deal with constraints, which is, however, difficult to control the penalty parameters. This paper therefore presents a new constraint handling scheme. It adaptively defines an extended-feasible region that includes not only all feasible solutions, but some infeasible solutions near the boundary of the feasible region. Furthermore, we construct a new fitness function based on stochastic ranking, and meanwhile propose a new crossover operator that can produce more good individuals in general. Accordingly, a new evolutionary algorithm for constrained optimization problems is proposed. The simulations show the efficiency of the proposed algorithm on four benchmark problems.