Miracle-dz/UniFAR-FTUs huggingface dataset:
Statistical Methods and Software for the Multilevel Social Relations Model

The multilevel social relations model (SRM) is a commonly used statistical method for the analysis of social networks. In this article and accompanying supplemental materials, we demonstrate the estimation and interpretation of the SRM using Stat-JR software. Multiple software templates permit the analysis of different response types, including binary, counts, and continuous responses.
Pembrolizumab vs docetaxel for previously treated advanced NSCLC with a PD-L1 tumor proportion score (TPS) 1%-49%: Results from KEYNOTE-010.

9024Background: KEYNOTE-010 (NCT01905657) showed that the anti–PD-1 antibody pembrolizumab (pembro; MK-3475) at doses of 2 and 10 mg/kg Q3W provided superior OS over docetaxel in patients (pts) wit.
Artefacts caused by intracranial aneurysm clip: a study comparing different CT scan techniques

Poster: "ECR 2017 / C-2787 / Artefacts caused by intracranial aneurysm clip: a study comparing different CT scan techniques" by: "V. Harsaker, H. Lund, K. Nodeland, K. Olsen, O. L. Taranrod; Oslo/NO"
Ecoconception des caves : réduction de la consommation d'énergie et intégration paysagère du traitement des eﬀuents de cave avec le dispositif de lit planté de roseaux sur support de zéolithe Zeofito®

Le traitement aérobie des eﬀuents vinicoles est majoritairement utilisé dans les caves. Au-delà des impératifs de performance d'épuration, avec les orientations de développement durable, le traitement doit intégrer plusieurs orientations : faible consommation d'énergie, limitation des boues, valorisation paysagère et de la biodiversité, limitation des nuisances olfactives et sonores, et éventuellement la réutilisation des eﬀuents traités pour l'irrigation. Les dispositifs classiques de phyto-épuration sur lit de sable, qui permettent de traiter des eﬀuents avec une DCO généralement inférieure à 2 g/l, imposent le plus souvent un bassin de stockage aéré conséquent, consommateur d'énergie, source éventuelle de nuisance olfactive, visuelle et sonore. Le procédé Zeofito®, qui équipe maintenant une centaine de caves dans différentes régions italiennes, accentue grâce au support de zéolithe, les mécanismes d'adsorption et de biodégradation. Ainsi, il est possible de réaliser un traitement direct ou éventuellement avec un petit bassin de stockage d'égalisation/aération, correspondant à quelques jours de rejet. La réutilisation de l'eau pour le dispositif de refroidissement de la cave ou l'irrigation des vignes est facilitée comparativement aux dispositifs classiques. Parallèlement au principe et aux performances, l'objectif de la communication est de présenter des installations représentatives de la diversité des caves.
Hematopoiesis Shows Closer Correlation with Calculated Free Testosterone in Men than Total Testosterone.

Serum total testosterone (tT)9 includes both free testosterone (fT) (0.5%–3% of total and believed to be the biologically active form) and sex hormone–binding globulin (SHBG)- and albumin-bound forms (1). Guidelines for diagnosing and treating male hypogonadism that emphasize measurement of tT (2) may not address the major variations in SHBG and consequent testosterone bioavailability (testosterone bioavailability [BT] either calculated or assayed directly) that are associated with age, obesity, anticonvulsant therapy, and thyroid and liver disease. For these reasons, recent Endocrine Society of Australia guidelines (3) acknowledge the value of measuring SHBG as well as BT, but nevertheless state that, “There is no evidence that free or bioavailable testosterone levels, which are usually not directly measured but calculated…are a better measure of androgen status than total testosterone level. Moreover, reference intervals for these [BT levels] are even less well defined than those for measured testosterone concentrations. Therefore, they [BT levels] are not recommended for clinical decision-making. ” Although commercially available direct fT assays are not always robust, calculated fT (c-fT) values from a mass-action …
ANTECEDENTES DA INTENÇÃO DE RECOMPRA EM APLICATIVO DE HOSPEDAGEM

O avanco tecnologico tem possibilitado o desenvolvimento de novos formatos de negocios no contexto virtual, sendo os casos dos aplicativos de reserva de locais e de experiencias. No entanto, ainda sao criadas barreiras no consumo em tais aplicativos, por conta da confianca dos participantes. Nesse sentido, o artigo tem como objetivo identificar a influencia da utilidade percebida, da facilidade de uso e da confianca na empresa e em terceiros na intencao de recompra em aplicativos de hospedagem. Para isso, foi realizada uma survey com 176 usuarios de um aplicativo de hospedagem (Airbnb) e a analise realizada por meio da modelagem de equacoes estruturais (MEE). Os resultados apresentaram que a utilidade percebida e facilidade de uso influenciam positivamente na intencao de recompra, porem a confianca na empresa e em terceiro nao foi positiva. Alem disso, a utilidade percebida influenciou positivamente a confianca na empresa e em terceiros, o que nao ocorreu com a facilidade de uso. A pesquisa contribuiu para uma reflexao a respeito da nova economia ou da economia compartilhada, possibilitando reflexoes para as empresas no que tange a importância da percepcao de utilidade de seus aplicativos. Palavras-chave: Percepcao de utilidade. Facilidade de uso. Confianca. Intencao de recompra. Aplicativos moveis. ABSTRACT The technological advance has made possible the development of new business formats in the virtual context, being the cases of applications of places reservation and experiences. However, consumption barriers are still created in such applications, because of the confidence of the participants. In this sense, the article aims to identify the influence of perceived utility, ease of use and trust in the company and third parties in the intention of repurchase in hosting applications. For this, a survey was carried out with 176 users of a hosting application (Airbnb) and the analysis performed through structural equation modeling (SEM). The results showed that the perceived utility and ease of use positively influence the repurchase intention, but confidence in the company and in the third one was not positive. In addition, perceived utility positively influenced trust in the company and in others, which did not occur with ease of use. The research contributed to a reflection about the new economy or the shared economy, allowing reflections for companies on the importance of the perception of utility of their applications. Keywords: Perceived usefulness. Perceived ease of use. Trust. Repurchase intention. Mobile apps.
Progressionen in der muskuloskelettalen Rehabilitation

Nach Muskel- und Bandverletzungen oder Knochenbrüchen hängt in der Rehabilitation viel davon ab, dass die Belastung adäquat gesteigert wird. Die Kontrolle bestimmter klinischer und funktioneller Parameter hilft dabei, die richtigen Entscheidungen zu treffen.
When and Why Saying “Thank You” Is Better Than Saying “Sorry” in Redressing Service Failures: The Role of Self-Esteem

In their initial recovery efforts after a service failure, service providers need to decide what to communicate to consumers to restore their satisfaction. Prior work has primarily examined apology (saying “sorry”) as a symbolic recovery strategy; the current research suggests appreciation (saying “thank you”) as an alternative, often more effective strategy. Drawing from research on linguistic framing and self-view, the authors reason that the shift of focus in the service provider–consumer interaction, from emphasizing service providers’ fault and accountability (apology) to spotlighting consumers’ merits and contributions (appreciation), can increase consumers’ self-esteem and, in turn, postrecovery satisfaction. Across multiple service failure contexts, Studies 1a–1e establish the superiority of appreciation in redressing service failures. By measuring and manipulating self-esteem and examining the moderating role of narcissism and recovery timing, Studies 2–5 provide converging evidence for consumers’ state self-esteem as the underlying mechanism. Studies 6 and 7 go beyond examining appreciation in isolation and show that it is as effective as recovery messages that combine appreciation and apology (Study 6) and that its superiority over apology holds when service providers combine symbolic and utilitarian recovery (Study 7).
Mucosal Foxp3 + Regulatory T Cells Show Significant Numerical Differences in Patients with Intestinal Graft-Versus-Host Disease Compared to Infectious Diseases of the Gut.

Objectives: The clinical diagnosis of intestinal GvHD is often complicated, even if bioptical material is present. So far, it is difficult to separate between GvHD and infectious complications, since distinguishing immunological features are not established. In a multicenter study, we quantified Foxp3 + immunoregulatory T cells (T reg ) and effector T cells in the intestinal mucosa of patients with acute or chronic GvHD, and infectious diseases of the gut. Methods: 95 paraffin-embedded tissue samples (44 with acute GvHD, 18 with chronic GvHD and 33 without histological GvHD) derived from intestinal biopsies from 49 patients undergoing allogeneic stem cell transplantation, and 12 inflammatory controls (6 patients with CMV-colitis and 6 with diverticulitis) were analysed by double immunoenzymatic labeling. Serial sections were stained for CD4, CD8 and co-stained for CD3/Foxp3 and CD25/Foxp3. In addition, lamina propria lymphocytes were isolated from intestinal biopsies by collagenase digestion and further characterized by flow-cytometry in comparison to peripheral blood lymphocytes in 24 patients with suspected GvHD after allogeneic stem cell transplantation and healthy controls. Results: The number of CD3 + T cells was extensively increased in intestinal GvHD, CMV colitis and diverticulitis. Though the number of CD8 + cells was similar, we saw striking differences in the frequency of Foxp3 + T reg in relation to CD8 + effector T cells. The number of Foxp3 + T cells per 100 CD8 + T cells was significantly lower in GvHD samples (1.7 ± 0.2) than in CMV colitis (27.4 ± 2.5) or diverticulitis (50.0 ± 4.4). Within the allogeneic transplanted patients, samples without histological signs of GvHD had also significantly elevated numbers of Foxp3 + /100 CD8 + T cells (14.1 ± 2.0) compared to acute (1.7 ± 0.2) and chronic GvHD (2.9 ± 0.8) and healthy controls (2.0 ± 0.3). Conclusion: In contrast to infectious diseases of the gut, GvHD is characterized by a considerable decrease of mucosal T reg cells. Together with recent experimental data, our results give new insights in the pathophysiology of intestinal GvHD and can be helpful for the precise diagnosis of intestinal complications after allogeneic stem cell transplantation.
A Bibliometric Analysis of Digital Image Forensics

ABSTRACT We present a bibliometric analysis of the evolving field of digital image forensics (DIF) from 2014 to early 2020. The study analyses and discusses the results obtained from the highly indexed Scopus database for various subject areas, renowned authors, funding agencies, and affiliations using a mind map approach. We adapt the PRISMA methodology formerly applied for systematic reviews to refine our search results. The results of this study indicate an increasing awareness of DIF in countries like China, India, and Italy along with an increase in publications since 2018, specifically, with the application of deep learning techniques for DIF.
Dual-sensing genetically encoded fluorescent indicators resolve the spatiotemporal coordination of cytosolic abscisic acid and second messenger dynamics in Arabidopsis

Deciphering signal transduction processes is crucial for understanding how plants sense and respond to environmental changes. Various chemical compounds function as central messengers within deeply intertwined signaling networks. How such compounds act in concert remains to be elucidated. We have developed dual-sensing genetically encoded fluorescent indicators (2-In-1-GEFIs) for multiparametric in vivo analyses of the phytohormone abscisic acid (ABA), Ca2+, protons (H+), chloride (anions), the glutathione redox potential (EGSH) and hydrogen peroxide (H2O2). Simultaneous analyses of two signaling compounds in Arabidopsis (Arabidopsis thaliana) roots revealed that ABA treatment and uptake did not trigger rapid cytosolic Ca2+ or H+ fluxes. Glutamate, ATP, Arabidopsis PLANT ELICITOR PEPTIDE (AtPEP1) and glutathione disulfide (GSSG) treatments induced rapid spatiotemporally overlapping cytosolic Ca2+, H+ and anion fluxes, but except for GSSG only weakly affected the cytosolic redox state. Overall, 2-In-1-GEFIs enable complementary high-resolution in vivo analyses of signaling compound dynamics and facilitate an advanced understanding of the spatiotemporal coordination of signal transduction processes in Arabidopsis.
Power production in intermittent exercise of short term after two protocols of heating/Diferencas na producao de potencia em exercicio intermitente maximo de curta duracao apos dois protocolos de aquecimento

In the absence of evidence to support the use of static stretching to increase the physical performance the research turned to the warm-up procedures, which aims to prepare the body for more intense physical activity. The results of this study may contribute to the understanding of the effect of various warm-up protocols on exercise performance. The aim of this study was to compare the intermittent exercise performance two warm-up protocols. Eight physically active male subjects participated of this study. The intermittent exercise involved ten all-out 6-s cycling sprints on a cycle ergometer, loaded to 7,5% of body weight, interspersed with 30 seconds of passive recovery. The warm-up protocol A involved a intermittent warmup, five minutes, with three all-out six seconds and increasing work rate. The warmup protocol B involved five minutes of continuous exercise. Shapiro-Wilk normality test was used, after Shapiro-Wilk test, T-test and the Wilcoxon test was used according to data distribution. There were significant differences in favor of warm-up protocol A in the higher power generated during the test and for the first three blocks of effort. These results suggest that performance during short bout of highintensity intermittent exercise is influenced by warm-up type.
Neutrophil gelatinase-associated lipocalin作為貓隻腎臟疾病的生物標記

Neutrophil gelatinase-associated lipocalin (NGAL) is emerging as a potential biomarker for early prediction of acute kidney injury (AKI), differentiation of AKI from chronic kidney disease (CKD), and the prognosis of AKI and CKD in human and canine medical studies. Nevertheless, the role of NGAL in feline kidney disease has never been studied. The purpose of this study was to determine the relationship between NGAL and different renal diseases in cats. From Sep 2014 to Mar 2016, 92 cats with azotemia were enrolled. According to the International Renal Interest Society (IRIS) staging system, the cats were categorized into five groups, (1) healthy cats, (2) cats with IRIS CKD stage II, (3) cats with IRIS CKD stage III, (4) cats with IRIS CKD stage IV, and (5) cats with AKI stages II-V. Urine and plasma samples of cats were collected at admission and tested for NGAL concentrations by our in-house sandwich ELISA system. The urinary NGAL (uNGAL) to creatinine ratio (UNCR) was also calculated. Simultaneously, hematologic and serum biochemical data of each case were also recorded. Statistically the uNGAL and UNCR of azotemic cats are significantly higher than those of healthy cats (i.e., uNGAL：Median [IQR] 1.8 [3.48] ng/mL in azotemic cats vs. 0.95 [1.35] ng/mL in healthy cats; UNCR：Median [IQR] 2.58 [8.23]% in azotemic cats vs. 0.23 [0.59]% in healthy cats), while plasma NGAL(pNGAL) had no statistical significance (p=0.113) between two groups. Unlike previous studies that increased pNGAL was associated with AKI in human medicine, the present findings indicated that only uNGAL and UNCR had significantly difference between AKI and healthy cats. Among CKD groups, cats with CKD grade 3, 4 had higher uNGAL and UNCR compared with cats with CKD grade 2 and healthy cats. For all patients, UNCR value was significantly correlated with uNGAL, plasma creatinine, hematocrit, segment and phosphorus concentrations. However, uNGAL concentration and UNCR were not associated with pNGAL concentration for all cases. According to the Receiving operative charaterstic (ROC) analysis, uNGAL and UNCR are useful to predict clinical progression for cats with CKD. Area under ROC (AUROC) for uNGAL in predicting the progression of CKD was 0.71 and the best cutoff value of 2.06 ng/mL had a sensitivity of 76.9% and specificity of 75％, whereas AUROC for UNCR in predicting the progression of CKD was 0.79 and the best cutoff value of 4.08% had a sensitivity of 76.9% and specificity of 79.2%. Above these values, patients experienced significantly faster deterioration within 19-20 days. In conclusion, uNGAL and UNCR could serve as useful biomarkers in cats with renal diseases. Furthermore, the CKD cats with higher concentration of uNGAL and UNCR tended to have poor clinical progression.
A Comparative Study of Whole-Mouth Taste Thresholds between North Korean Refugees and South Koreans

Since Korea was divided into two countries over 60 years ago, differences have gradually developed at the political and economic levels. Because North Koreans have faced food shortages since the early 1990s, the number of North Korean refugees arriving in South Korea has soared, with more than 30000 settling in South Korea. North Korean refugees stay at Hanawon, a settlement support center, during their first 3 months after entry into South Korea. Their complaints regarding taste intensity, particularly with respect to strong sweetness, of prepared or processed foods at Hanawon are common, and they persist even after the refuA Comparative Study of Whole-Mouth Taste Thresholds between North Korean Refugees and South Koreans
Competent women, subliminal group hierarchies and executiveleadership

Objective: We analysed the experiences of successful executive women leaders to ascertain how they attained appointments to roles as high as the C-suite and boardroom. Theoretical focus: Sociologists use ‘status characteristics theory’ (SCT) to explain the influence of status beliefs based on salient characteristics, such as gender, on the assessment of a person’s competency in group task situations (Berger et al. 1980). SCT suggests women can elevate their position from their stereotypically assigned place in the subliminal group hierarchy by shortening the path of relevance (Berger et al. 1980) between perceptions of their gender and their competence to perform a leadership role. Research question: What strategies do successful executive women use to overcome subliminal, gender-influenced assessments of their leadership competency? Method: In 2016, we interviewed 25 women who held positions within the executive suite and/or on the Board of Australian companies and government departments. A thematic analysis adhering to a ‘contextualist’ approach (Braun & Clarke, 2006) was applied to examine the participants’ responses. Major conclusions: The women demonstrated their competence via two overarching strategies: active demonstrations with associated internal dialogues. Under these two strategies sit four sets of mirror-imaged tactics: balanced career choices; outcome driven; image management; and leveraged relationships. Combined, these inputs reflect physical and mental manoeuvres women have used to achieve shortened paths of relevance, suggesting that they reconfigured the cognitive, stereotypical status assessment of being less competent than the men in the group, to being viewed as a person capable of an executive leadership role.
Cytokines and Thyroid Autoimmunity

Cytokines may play important roles in the development and perpetuation of autoimmunity. In this paper are briefly reviewed selected data on the relationship between cytokines and thyroid autoimmune diseases (AITD), which represent a typical example of organ-specific autoimmune endocrinopathy. The availability of high efficiency T-cell cloning techniques recently allowed the phenotipic and functional characterization of T lymphocytes derived from thyroid infiltrates of patients with Graves' disease and Hashimoto's thyroiditis. A high prevalence of T cell clones with cytolytic potential and displaying increased γ-interferon production was observed in both diseases; in contrast, high tumor necrosis factor-α secretion was a peculiar characteristic of T-cell clones derived only from Hashimoto's infiltrates. The production of IL-4 by CD4 + T cell clones from AITD infiltrates was remarkably low, suggesting a quite homogeneous populations of Thl-type «inflammatory» T cells. This pattern of cytokine production by thyroid infiltrates may be important not only in triggering and/or maintaining thyroid autoimmune reaction, but could also modulate the expression of AITD by exerting direct functional effects on thyroid epithelial cells, as suggested by recent in vitro studies.
A Cost-Constrained Active Capacitor for a Single-Phase Inverter

The active capacitor concept based on power electronic circuits has been proposed recently to exceed the physical limit of the passive capacitor. It retains the physical convenience of use as a passive capacitor and has the potential to increase either the power density or the lifetime depending on the applications. However, the cost of the existing design by using ceramic or film capacitors to achieve extreme performance increases a lot, which must be taken into account in the design from the industry aspect. This article proposes a cost-constrained design of an active capacitor used for dc-link applications. It is implemented based on high-current electrolytic capacitors instead of film capacitors or ceramic capacitors. A model-based optimization design procedure is discussed in terms of performance factors of interest. A case study of a 5.5-kW single-phase inverter demonstrates a 38% volume reduction of the dc link with the proposed active capacitor under specific constraints of cost, volume, power loss, and lifetime. The outcomes move one step further for the practical application of the active capacitor concept.
Vergleich von Holstein- und Jerseykühen unter besonderer Berücksichtigung genetisch-physiologischer Unterschiede

Zusammenfassung Jersey- und Holsteinrinder unterscheiden sich z.T. erheblich in den Milchleistungsmerkmalen und in den funktionellen Eigenschaften, die spezifisch genutzt werden konnen. Holsteinrinder dominieren die aktuelle Milcherzeugung in Deutschland. Das Jerseyrind (einschlieslich Jersey-Kreuzungen) besitzt unter den Bedingungen eines Vollweidesystems besondere Vorzuge, die zukunftig auch in Deutschland starker zu beachten sind. Die Grose der Deutschen Jerseypopulation reicht nicht aus, ein eigenes Zuchtprogramm zu realisieren. Zuchterischen Aktivitaten begrunden deshalb die enge internationale Zusammen-arbeit speziell mit Danischen und US-amerikanischen Jerseyzuchtern. Die Reaktion auf eine erhohte Kraftfutterfutterung unterscheidet sich zwischen den beiden Rassen signifikant. Der Methanertrag (Methanbildung pro kg Trockenmasse-aufnahme) wird bei Holsteinkuhe in einem groseren Ausmas als bei Jerseykuhen gesenkt, wenn der Kon-zentratanteil in der Nahrung systematisch erhoht wird. Dies wird begleitet mit einer signifikant starkeren Reduktion des Pansenacetat: Propionat-Verhaltnisses im Pansensaft der Holstein-kuhe im Vergleich zu Jerseykuhen. Die Methanbildung pro Einheit energiekorrigierte Milch differiert jedoch nicht zwischen den beiden Rassen. Die Wahl der zu haltenden Rasse/Kombination bleibt betriebsabhangig (Emotionalitat, Hal-tungsbedingungen, Futterressourcen, Vermarktung etc.). Der Milchkuhhalter sollte diejenige Rasse/Kombination nutzen, mit der er unter seinen Bedin-gungen am besten zurechtkommt. Die Bedingungen sind nicht gleich, sondern in praxi eben vielfaltig.