Miracle-dz/UniFAR-FTUs huggingface dataset:
Inverted Encoding Models Reconstruct an Arbitrary Model Response, Not the Stimulus

Abstract Probing how large populations of neurons represent stimuli is key to understanding sensory representations as many stimulus characteristics can only be discerned from population activity and not from individual single-units. Recently, inverted encoding models have been used to produce channel response functions from large spatial-scale measurements of human brain activity that are reminiscent of single-unit tuning functions and have been proposed to assay “population-level stimulus representations” (Sprague et al., 2018a). However, these channel response functions do not assay population tuning. We show by derivation that the channel response function is only determined up to an invertible linear transform. Thus, these channel response functions are arbitrary, one of an infinite family and therefore not a unique description of population representation. Indeed, simulations demonstrate that bimodal, even random, channel basis functions can account perfectly well for population responses without any underlying neural response units that are so tuned. However, the approach can be salvaged by extending it to reconstruct the stimulus, not the assumed model. We show that when this is done, even using bimodal and random channel basis functions, a unimodal function peaking at the appropriate value of the stimulus is recovered which can be interpreted as a measure of population selectivity. More precisely, the recovered function signifies how likely any value of the stimulus is, given the observed population response. Whether an analysis is recovering the hypothetical responses of an arbitrary model rather than assessing the selectivity of population representations is not an issue unique to the inverted encoding model and human neuroscience, but a general problem that must be confronted as more complex analyses intervene between measurement of population activity and presentation of data.
Trends and Patterns of Burden of Disease and Injuries in Korea Using Disability-Adjusted Life Years

Background It is extremely important to objectively take a view of population health to provide useful information to decision makers, health-sector leaders, researchers, and informed citizens. This study aims to examine the burden of disease in Korea as of 2015, and to study how the burden of disease changes with the passage of time. Methods We used results from the Korean National Burden of Disease and Injuries Study 2015 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive disability-adjusted life years (DALYs) by gender and age groups from 2007 to 2015. DALYs were calculated as the sum of the years of life lost (YLLs) and the years lived with disability (YLDs). Results In 2015, the burden of disease for Korean people was calculated at 29,476 DALYs per 100,000 population. DALYs caused by low back pain were the highest, followed by diabetes mellitus and chronic obstructive pulmonary disease. The burden of disease showed a consistently increasing trend from 2007 to 2015. Although YLLs have been on the decrease since 2011, the increase in YLDs has contributed to the overall rise in DALYs. The DALYs per 100,000 population in 2015 increased by 28.1% compared to 2007. Conclusion As for the diseases for which the burden of disease is substantially increasing, it is needed to establish appropriate policies in a timely manner. The results of this study are expected to be the basis for prioritizing public health and health care policies in Korea.
Evaluation of Nanomechanical Properties, Surface Roughness, and Color Stability of Esthetic Nickel-Titanium Orthodontic Archwires

Objectives: The objective of the study is to evaluate the surface roughness, nanomechancial properties the color stability of three brands of coated (rhodium, epoxy, and Teflon) nickel-titanium (NiTi) esthetic archwires. Materials and Methods: Three brands of coated (rhodium, epoxy, and Teflon) esthetic NiTi archwires and three brands of uncoated (NiTi) archwires from the same manufactures were evaluated for the surface roughness, nanomechanical properties, and color stability. The specimens with 20 mm length (n = 5) were cut from the straight buccal segments of the coated and uncoated archwires. The specimens with 20 mm length (n = 10) were subjected to color measurement after immersion in a coffee staining solution. The color measurement was evaluated after 7, 14, 21, and 28 days after immersion in staining solution using color eye 7000 spectrophotometer. The experimental data were analyzed using descriptive statistics, analyses of variance, and Tukey's post hoc test. Results: Epoxy (1.517 ± 0.071) and rhodium (0.297 ± 0.015) coated archwires showed the highest and lower value of surface roughness. All the intergroup comparisons showed a significant difference (P < 0.05) in surface roughness except between rhodium and control group (P = 0.998). There were significant differences between control and the experimental groups for both nanohardness and elastic modulus was observed. All the three NiTi-coated esthetic archwires demonstrated trace” (extremely slight change) color changes as measured by the National Bureau of Standards units after 4 weeks of immersion. Conclusion: Surface roughness of rhodium-coated archwires was almost similar to that of uncoated wires. Whereas Teflon and epoxy coated archwires showed a significant difference in surface roughness compared to uncoated archwires. Uncoated archwires showed higher nanohardness values compared to the coated archwires. Teflon-coated archwires demonstrated significantly slight color change after 4 weeks of immersion in staining solution.
Negative pressure wound therapy with instillation without open‐window thoracostomy for empyema

Treatment of empyema is very challenging. The use of negative pressure wound therapy (NPWT), and NPWT with instillation and dwell time (NPWTi‐d) for wound closure have attracted attention. However, they are both limited to use after open‐window thoracostomy (OWT) performed to control infection. In some patients with poor general conditions, who cannot undergo surgery, no treatment for empyema is available. Therefore, we devised a new treatment for such patients with NPWTi‐d without OWT (non‐OWT NPWTi‐d). Here we present the cases of two patients with refractory empyema after intrathoracic irrigation and drainage, who underwent non‐OWT NPWTi‐d using the fistula of the thoracic drain. Both the patients recovered. The first patient was treated for 31 days. As the empyema persisted, he underwent a repeat intrathoracic drainage after which the wound healed. The second patient was treated for 20 days. Non‐OWT NPWTi‐d may be a new option to treat empyema.
Control Strategies and Daily Affect

Abstract. Adjusting strategies to manage daily goal pursuit with new functional limitations may impact not only the affect of patients, but also that of their partners. Associations between patients’ control strategies and both partners’ affect were examined at the onset of patients’ incontinence following prostatectomy. Eight-day diary data from 180 heterosexual couples were used to fit two-level models. In patients, investing personal resources to keep up goal pursuit despite incontinence (selective primary control) was associated with better affect, particularly when incontinence was pronounced. Yet, partners’ decreased negative affect coincided with patients’ asking for help and using technical aids (compensatory primary control) when the incontinence was severe. Patients and partners may benefit from different control strategies used by patients, especially when their functional limitations are pronounced.
Associations of Maternal Sociodemographic Characteristics and Eating Behaviors with Infant Feeding Behaviors

This study examines associations of maternal characteristics with infant feeding of discretionary and health-promoting foods. Mothers in PEAS, a prospective cohort study, reported maternal and child dietary intake, demographics, and eating competence (EC). Maternal diet quality (Healthy Eating Index-2015, HEI) was calculated combining 24-hour diet recalls at 6 weeks, 6, and 12 months postpartum (n = 209). Infant food frequency questionnaires were completed at 6, 9, and 12 months, assessing age of introduction and intake frequency of food groups. T-tests examined bivariate associations of demographics with feeding of discretionary sweets, discretionary savory foods, fruit, and vegetables. Linear regressions examined associations of maternal EC and HEI with infant feeding controlling for demographics. Fruit, vegetables, discretionary sweet, and discretionary savory foods were introduced at 5.8 ± 1.7, 5.9 ± 1.7, 8.0 ± 2.0, and 8.8 ± 1.8 months, respectively. Earlier introduction of fruit and vegetables was associated with higher maternal education, white race, and nulliparity; earlier introduction of vegetables was also associated with higher income. Age of introduction of discretionary sweet and savory foods was not associated with maternal demographics, HEI, or EC. At age 12 months, greater infant intake frequency of fruit and vegetables was associated with higher education and income, white race, and breastfeeding, while greater intake frequency of discretionary sweet and savory foods was associated with lower maternal education and minority race. Greater intake frequency of sweets was also associated with multiparity and greater intake frequency of discretionary savory foods was associated with lower income. Maternal HEI was positively associated with infant intake frequency of fruit, vegetables, and discretionary sweet and savory foods. Maternal EC was positively associated with infant intake frequency of fruit and vegetables. Demographic differences in infant feeding behaviors indicates these behaviors as critical intervention targets to address disparities in child diet quality. Associations of maternal HEI and EC with infant feeding behaviors suggest potential pathways of maternal influence on infant diet. This research was supported by the NICHD Intramural Research Program.
Identification of a Functional Non-coding Variant in the GABAA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research

GABA type-A (GABA-A) receptors containing the α2 subunit (Gabra2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the GABRA2 locus has been implicated in epilepsy, affective and psychiatric disorders, alcoholism and drug abuse. Gabra2 expression varies as a function of genotype and is modulated by sequence variants in several brain structures and populations, including F2 crosses originating from C57BL/6J (B6J) and the BXD recombinant inbred family derived from B6J and DBA/2J. Here we demonstrate a global reduction of Gabra2 brain mRNA and protein in the B6J strain relative to other inbred strains, and identify and validate the causal mutation in B6J. The mutation is a single base pair intronic deletion located adjacent to a splice acceptor site that only occurs in the B6J reference genome. The deletion became fixed in B6J between 1976 and 1991 and is now pervasive in many engineered lines, BXD strains generated after 1991, the Collaborative Cross, and the majority of consomic lines. Repair of the deletion using CRISPR-Cas9 mediated gene editing on a B6J genetic background completely restored brain levels of Gabra2 mRNA and protein. Comparison of transcript expression in hippocampus, cortex, and striatum between B6J and repaired genotypes revealed alterations in GABA-A receptor subunit expression, especially in striatum. These results suggest that naturally occurring variation in GABRA2 levels between B6J and other substrains or inbred strains may also explain strain differences in anxiety-like or alcohol and drug response traits related to striatal function. Characterization of the B6J private mutation in the Gabra2 gene is of critical importance to molecular genetic studies in neurobiological research as this strain is widely used to generate genetically engineered mice and murine genetic populations, and is the most widely utilized strain for evaluation of anxiety-like, depression-like, pain, epilepsy, and drug response traits that may be partly modulated by Gabra2 function.
Exotic Patterns of Synchrony in Planar Lattice Networks

Patterns of dynamical synchrony that can occur robustly in networks of coupled dynamical systems are associated with balanced colorings of the nodes of the network. In symmetric networks, the orbits of any group of symmetries automatically determine a balanced orbit coloring. Balanced colorings not of this kind are said to be exotic. Exotic colorings occur in infinite planar lattices, both square and hexagonal, with various short-range couplings. In some cases, a balanced two-coloring remains balanced when colors are swapped along suitable diagonals, giving rise to uncountably many distinct exotic colorings. We explain this phenomenon in terms of iterated orbit colorings, in which the quotient of the lattice by an orbit coloring has extra symmetries, allowing new orbit colorings on the quotient, which then lift back to the lattice. We apply the same construction to several other exotic lattice colorings. Two appendices discuss how to modify the notion of balance for networks with diffusive coupling, and how to formalize the differential equations in infinitely many variables that arise for lattices.
Sahlqvist via Translation

We investigate to what extent Sahlqvist-type results for nonclassical logics can be obtained by embedding into classical logic via some G\"odel-type translations. We prove the correspondence theorem via translation for inductive inequalities of arbitrary signatures of normal distributive lattice expansions. We also show that canonicity-via-translation can be obtained in a similarly straightforward manner, but only in the special setting of normal bi-Heyting algebra expansions. We expand on the difficulties involved in obtaining canonicity-via-translation outside of the bi-Heyting setting.
Dynamic capabilities for smart manufacturing transformation by manufacturing enterprises

ABSTRACT This study develops a dynamic capability-based framework of maturity assessment through combinative capabilities towards smart manufacturing transformation. First, the relationship between existing maturity models and dynamics capability is investigated. The finding indicates that most maturity models cannot identify an organisation’s dynamic capability or examine this capability in a dynamic and competitive environment during the transition. On the basis of the literature and senior executives’ experiences, this study incorporates dynamics capability into the maturity model assessment developed by the Singapore Economic Development Board for empirical analysis and identification of the importance of key capabilities with influencing factors, which are included in a framework to fill the research gap. Primary data obtained from in-depth interviews are systemically examined to determine the industrial maturity level and dynamics capability driving the transformation. Drawing on this investigation, this paper proposes a conceptual framework for smart manufacturing transformation driven by dynamic capabilities that have positive effects on the transformation of manufacturing enterprises. Our main contribution is identification of the four key aspects of dynamic capability – process, technology, organisation, and transformation. Another contribution is that we provide dynamic capability-based guidance for enterprises to re-evaluate their strategies and strengthen the capabilities they require to face a changing environment.
Antioxidative activity of oyster protein hydrolysates Maillard reaction products

Abstract A two‐step process of enzymatic hydrolyzation followed by Maillard reaction was used to produce oyster meat hydrolysate Maillard reaction products (MRPs). The flavor of oyster meat hydrolysate MRPs was significantly improved through an optimized orthogonal experimental design. Comparisons between the antioxidative activities of oyster meat hydrolysates and their MRPs were made using lipid peroxidation inhabitation, hydroxyl radical scavenging radical activity, and radical scavenging activity of 2,2 diphenyl‐1‐picrylhydrazyl (DPPH). These methods indicated that an improvement of Maillard reaction on the oyster meat hydrolysates antioxidative activity. Gas chromatography‐mass spectrometry illustrated that the increase was due to the newly formed antioxidative compounds after Maillard reaction, mainly of acids from 22.45% to 37.77% and phenols from 0% to 9.88%.
The Effects of Intact Cereal Grain Fibers, Including Wheat Bran on the Gut Microbiota Composition of Healthy Adults: A Systematic Review

The human microbiota is increasingly recognized as a major factor influencing health and well-being, with potential benefits as diverse as improved immunity, reduced risk of obesity, Type 2 diabetes, and improved cognition and mood. Bacteria inhabiting the gut are dependent on the provision of fermentable dietary substrates making diet a major factor driving the composition of the human gut microbiota. Dietary fiber may modify microbiota abundance, diversity, and metabolism including short-chain fatty acid production. The majority of research to date has explored isolated fibers, and the influence of habitual fiber consumption is less well-established. The aim of the current article was to systematically review evidence from human intervention studies for the effects of intact cereal fibers, and their active sub-fractions, on gut microbiota composition in healthy adults. Studies published in the past 20 years were identified through the PubMed and Cochrane electronic databases. Inclusion criteria were: healthy adult participants (>18 years), inclusion of at least one intact cereal fiber, or its sub-fraction, and measurement of fecal microbiota related outcomes. As every individual has a unique microbiota many trials utilized a cross-over design where individuals acted as their own control. Outcome measures included change to the microbiota, species diversity, or species abundance, or metabolic indicators of microbiota fermentation such as short chain fatty acids or fecal nitrogen. Two hundred and twenty three publications were identified and 40 included in the final review. In discussing the findings, particular attention has been paid to the effects of wheat fiber, bran, and arabinoxylans (AXOS) as this is the dominant source of fiber in many Western countries. Thirty-nine of the forty-two studies demonstrated an increase in microbiota diversity and/or abundance following intact cereal fiber consumption, with effects apparent from 24 h to 52 weeks. Increases in wheat fiber as low as 6–8 g were sufficient to generate significant effects. Study duration ranged from 1 day to 12 weeks, with a single study over 1 year, and exploration of the stability of the microbiota following long-term dietary change is required. Increasing cereal fiber consumption should be encouraged for overall good health and for gut microbiota diversity.
Regulating IRFs in IFN Driven Disease

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal roles in many aspects of the immune response, including immune cell development and differentiation and regulating responses to pathogens. Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream of pathogen recognition receptors that detect viral RNA and DNA. A fourth family member, IRF9, regulates interferon-driven gene expression. In addition, IRF4, IRF8, and IRF5 regulate myeloid cell development and phenotype, thus playing important roles in regulating inflammatory responses. Thus, understanding how their levels and activity is regulated is of critical importance given that perturbations in either can result in dysregulated immune responses and potential autoimmune disease. This review will focus the role of IRF family members in regulating type I IFN production and responses and myeloid cell development or differentiation, with particular emphasis on how regulation of their levels and activity by ubiquitination and microRNAs may impact autoimmune disease.
Nonparametric additive factor models

We study an additive factor model in which the common components are related to the latent factors through unknown smooth functions. The model is new to the literature and generalizes nonlinear parametric factor models. Identification conditions are provided and a general nonparametric estimation procedure is specified. Convergence of the estimator is obtained when both time and cross-sectional size increase at appropriate rates. The finite sample performance is then illustrated in extensive numerical experiments. Finally, the relevance and usefulness of the method is shown in an application to a nonlinear CAPM on S&P500 data.
Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia

Formaldehyde (FA), the smallest aldehyde, is generated endogenously, and is widespread in the environment in foods, beverages and as a gas phase product of incomplete combustion. The main metabolite of FA, formate, was increased significantly in murine urine (∼3×) after overnight feeding. Because feeding increases mesenteric blood flow, we explored the direct effects of FA in isolated murine superior mesenteric artery (SMA). Over the concentration range of 30–1,200 μM, FA strongly and reversibly relaxed contractions of SMA induced by three different agonists: phenylephrine (PE), thromboxane A2 analog (U46,619) and high potassium (60K, 60 mM K+). Formate (to 1.5 mM) induced a modest relaxation. FA (>1,500 μM) irreversibly depressed vascular function in SMA indicating vasotoxicity. The sensitivity (EC50) but not the efficacy (% relaxation) of FA-induced relaxations was dependent on blood vessel type (SMA << aorta) and contractile agonist (PE, EC50= 52 ± 14 μM; U46,619, EC50= 514 ± 129 μM; 60K, EC50= 1,093 ± 87 μM). The most sensitive component of FA vasorelaxation was within physiological levels (30–150 μM) and was inhibited significantly by: (1) mechanically impaired endothelium; (2) Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME); (3) transient receptor potential ankyrin-1 (TRPA1) antagonist (A967079); (4) guanylyl cyclase (GC) inhibitor (ODQ); and, (5) K+ channel inhibitor (BaCl2). A similar mechanism of SMA vasorelaxation was stimulated by the TRPA1 agonist cinnamaldehyde. Positive TRPA1 immunofluorescent staining and gene-specific sequence were present in SMA but not in aorta. These data indicate FA, but not formate, robustly relaxes SMA via a sensitive TRPA1- and endothelium-dependent mechanism that is absent in aorta. Thus, as FA levels increase with feeding, FA likely contributes to the physiological reflex of post-prandial hyperemia via SMA vasodilatation.