Molecular mechanisms of FLT3-ITD-induced leukemogenesis

S PRESENTED (ORAL PRESENTATION) 2012 Midwest Blood Club Symposium, Indianapolis, IN, 2012. Nabinger SC, XJ Li, S Goenka, GS Feng, M Yu, GE Sandusky, R Kapur, and RJ Chan. The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3ITD-Induced Hematopoietic Progenitor Hyperproliferation and Malignant Disease In Vivo. 2011 Sigma Xi Graduate Research Competition, Indianapolis, IN, 2011. Nabinger SC. Shp2/STAT5 Nuclear Co-Localization in FLT3-ITDExpressing Leukemic Cells. 2010 Midwest Blood Club, Indianapolis, IN, 2010. Nabinger SC, Y He, F Yin, B Ramdas, X Zhang, LT Senbanjo, S Fukuda, M Yu, HS Boswell, GS Feng, ZY Zhang, R Kapur, and RJ Chan. Targeting the Protein Tyrosine Phosphatase, Shp2, May be a Future Therapeutic for FLT3-ITD-Positive AML. 2010 Sigma Xi Graduate Biomedical Research Competition, Indianapolis, IN 2010. Nabinger SC. Shp2 May be a Future Therapeutic Target for FLT3-ITD-Positive AML. 2009 American Society of Hematology, New Orleans, LA 2009. Nabinger SC, Y He, F Yin, X Zhang, LT Senbanjo, S Fukuda, M Yu, GS Feng, ZY Zhang, R Kapur, and RJ Chan. Targeting the Protein Tyrosine Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors. 2008 International Society of Experimental Hematology (ISEH), Boston, MA, 2008. Nabinger SC, S Fukuda, R Kapur, RJ Chan. The Role of Shp2 in FLT3-ITD-Induced Leukemogenesis. ABSTRACTS PRESENTED (POSTER PRESENTATIONS) 2011 International Society of Hematology, Vancouver, B.C., Canada, 2011. Nabinger SC, X Li, and RJ Chan. The Protein Tyrosine Phosphatase, Shp2, Demonstrates Interaction with STAT5 and Nuclear Localization in FLT3-ITD-Expressing Leukemic Cells. 2011 Midwest Blood Club, Cincinnati, OH, 2011. Nabinger, SC, X, Li, and RJ Chan. 2011. The Protein Tyrosine Phosphatase, Shp2, Demonstrates Interaction with STAT5 and Nuclear Localization in FLT3-ITDExpressing Leukemic Cells.S PRESENTED (POSTER PRESENTATIONS) 2011 International Society of Hematology, Vancouver, B.C., Canada, 2011. Nabinger SC, X Li, and RJ Chan. The Protein Tyrosine Phosphatase, Shp2, Demonstrates Interaction with STAT5 and Nuclear Localization in FLT3-ITD-Expressing Leukemic Cells. 2011 Midwest Blood Club, Cincinnati, OH, 2011. Nabinger, SC, X, Li, and RJ Chan. 2011. The Protein Tyrosine Phosphatase, Shp2, Demonstrates Interaction with STAT5 and Nuclear Localization in FLT3-ITDExpressing Leukemic Cells. 2011 Cancer Research Day, Indianapolis, IN 2011. Nabinger SC, X Li, and RJ Chan. The Protein Tyrosine Phosphatase, Shp2, Demonstrates Interaction with STAT5 and Nuclear Localization in FLT3-ITD-Expressing Leukemic Cells. 2009 Midwest Blood Club, Cincinnati, OH, 2009. Nabinger SC, S Fukuda, R Kapur, RJ Chan. Shp2 Plays a Key Role in FLT3-ITD-Induced Leukemogenesis. 2008 American Society of Hematology, San Francisco, CA, 2008. Nabinger SC, S Fukuda, R Kapur, and RJ Chan. The Role of Shp2 in FLT3-ITDInduced Leukemogenesis. GRANTS AND FELLOWSHIPS Improved Therapies for AML in the Elderly Principal Investigator, Sarah C. Nabinger Agency: NIH/Institute of Aging PUBLICATIONS 1. Nabinger SC, Chan RJ. Shp2 Function in Hematopoietic Stem Cell Biology and Leukemogenesis. “Invited Review”, Current Opinion in Hematology. Submitted. 2. Nabinger SC, Li X, Ramdas B, He Y, Zhang X, Fukuda S, Goenka S, Feng GS, Yu M, Sandusky GE, Boswell HS, Zhang ZY, Kapur R, and Chan RJ. The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Hematopoietic Progenitor Hyperproliferation and Malignant Disease In Vivo. Leukemia, revision invited. 3. Ma P, R Mali, L-F Zeng, H Martin, B Ramdas, Y He, E Sims, J Ghosh, SC Nabinger, J Ghosh, N Sharma, V Munugalavadla, A Chatterjee, S Li, G Sandusky, AW Craig, KD Bunting, GS Feng, RJ Chan, Z-Y Zhang, and R Kapur. 2012. Role of SHP2 phosphatase in KIT induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood, revision submitted. 4. Mali, R, B Ramdas, P Ma, J Shi, V Munugalavadla, E Sims, L Wei, S Vemula, SC Nabinger, CB. Godwin, RJ Chan, F Traina, V Visconte, RV. Tiu, TA Lewis, AM Stern, Q Wen, JD Crispino, HS Boswell, and R Kapur. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. Cancer Cell, 2011 Sep 13. 5. Sayar H, Chan RJ, Orschell CM, Chan EM, Yu Z, Hood D, Plett A, Yang Z, Hui CL, Nabinger SC, Kohlbacher KJ, West ES, Walter A, Sampson C, Wu J, Cripe LD. Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: A study of the Hoosier Oncology Group. Leuk Res. 2011 Mar 18. 6. Ranahan WP, Han Z, Smith-Kinnaman W, Nabinger SC, Heller B, Herbert BS, Chan R, Wells CD. The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signalregulated kinases. Cancer Res. 2011 Mar 15;71(6):2203-11. 7. Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY. (2010). Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J Med Chem. 53(6):2482-93. 8. Yang Z, Kondo T, Voorhorst CS, Nabinger SC, Ndong L, Yin F, Chan EM, Yu M, Würstlin O, Kratz CP, Niemeyer CM, Flotho C, Hashino E, Chan RJ. (2009). Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants. Mol Cell Biol. (16):4376-93. 9. Witting SR, Brown M, Saxena R, Nabinger S, Morral N. (2008). Helperdependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response. J Biol Chem. 283(4):2120-8. 10. Bard M, Sturm AM, Pierson CA, Brown S, Rogers KM, Nabinger S, Eckstein J, Barbuch R, Lees ND, Howell SA, Hazen KC. (2005). Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains. Diagn Microbiol Infect Dis. 52(4):285-93.