Miracle-dz/UniFAR-FTUs huggingface dataset:
Joint Regression Analysis of Correlated Data Using Gaussian Copulas

Summary This article concerns a new joint modeling approach for correlated data analysis. Utilizing Gaussian copulas, we present a unified and flexible machinery to integrate separate one‐dimensional generalized linear models (GLMs) into a joint regression analysis of continuous, discrete, and mixed correlated outcomes. This essentially leads to a multivariate analogue of the univariate GLM theory and hence an efficiency gain in the estimation of regression coefficients. The availability of joint probability models enables us to develop a full maximum likelihood inference. Numerical illustrations are focused on regression models for discrete correlated data, including multidimensional logistic regression models and a joint model for mixed normal and binary outcomes. In the simulation studies, the proposed copula‐based joint model is compared to the popular generalized estimating equations, which is a moment‐based estimating equation method to join univariate GLMs. Two real‐world data examples are used in the illustration.
A Comparative Study of Ergometrine with Oxytocin in Controlling Third Stage Blood Loss -A Randomized Control Trial

The present study was to determine the degree of fall in hemoglobin , hematocrit and need for blood transfusion following delivery in those receiving intramuscular methylergometrine and intramuscular oxytocin and also to compare the safety and efficacy of those two drugs. This was a randomized, comparative, prospective, single blinded, interventional, Hospital based clinical trial conducted in the labour room and maternity ward at R.G. Kar Medical College and Hospital, Kolkata, recruiting 400 women after matching, 200 in each two groups- Group A receiving intravmuscular methylergometrine, Group B receiving intramuscular oxytocin. 3 rd stage blood loss, systolic blood pressure, diastolic blood pressure, hemoglobin and hematocrit value before and after giving uterotonic are measured and recorded. Side effects of both uterotonic were recorded. Data were analysed by using SPSS Software version 18. The mean duration of the 3 rd stage was 6.40 minute in ergometrine group compared to 7.31 minute in oxytocin group. The difference was not statistically significant. The average blood loss was 194.7 ml in ergometrine group compared to 188.9 ml in oxytocin group. The fall in hemoglobin percentage was 0.89 g/dl in ergometrine group compared to 1.118 g/dl in oxytocin group. The difference in observation of both groups was statistically not significant (p>0.05). The fall in hematocrit was 2.41 ergometrine group compared to 2.65 in oxytocin group. The difference in observation of both groups was statistically not signifanat (p>0.05). The incidence of post partum hemorrhage was 3% in both the groups. There were 1 case of retained placentain either of the groups. Need for additional oxytocics was 4% in both the groups as they were given only when the blood loss is more than 500 ml in the present study. There was increase in blood pressure in ergometrine group and slight decrease in blood pressure in oxytocin group. Vomiting, leg cramp and chest pain were associated with inj methyl ergometrine. We found that both the drugs were equally effective in management of 3 rd stage of labor. However a comparison between two groups revealed that vomiting, leg cramp and rise in mean blood pressure were more common side effects with methyl ergometrine, and the two drugs did not confer any significant advantage over the other in terms of duration of 3 rd
Structural divergence of the rotary ATPases

Abstract The rotary ATPase family of membrane protein complexes may have only three members, but each one plays a fundamental role in biological energy conversion. The F1Fo-ATPase (F-ATPase) couples ATP synthesis to the electrochemical membrane potential in bacteria, mitochondria and chloroplasts, while the vacuolar H+-ATPase (V-ATPase) operates as an ATP-driven proton pump in eukaryotic membranes. In different species of archaea and bacteria, the A1Ao-ATPase (A-ATPase) can function as either an ATP synthase or an ion pump. All three of these multi-subunit complexes are rotary molecular motors, sharing a fundamentally similar mechanism in which rotational movement drives the energy conversion process. By analogy to macroscopic systems, individual subunits can be assigned to rotor, axle or stator functions. Recently, three-dimensional reconstructions from electron microscopy and single particle image processing have led to a significant step forward in understanding of the overall architecture of all three forms of these complexes and have allowed the organisation of subunits within the rotor and stator parts of the motors to be more clearly mapped out. This review describes the emerging consensus regarding the organisation of the rotor and stator components of V-, A- and F-ATPases, examining core similarities that point to a common evolutionary origin, and highlighting key differences. In particular, it discusses how newly revealed variation in the complexity of the inter-domain connections may impact on the mechanics and regulation of these molecular machines.
Circulatory responses to afterloading with phenylephrine in hyperdynamic sepsis

We assessed cardiac function by acute pressure loading with phenylephrine in 7 patients who had hyperdynamic sepsis and in 8 patients who had heart disease. All patients with sepsis had a positive Limulus lysate test, a septic focus, and a cardiac output (CO) greater than 6.0 L/min. Phenylephrine was given iv to elevate systolic arterial pressure by 30 mm Hg. Cardiac index (CI) and stroke index (SI) increased significantly in patients with hyperdynamic sepsis, whereas systemic vascular resistance index (SVRI) showed no change. In patients with heart disease, CI and SI decreased significantly, whereas SVRI increased significantly. The marked differences in response to phenylephrine by the two groups suggest lack of cardiac dysfunction in patients with hyperdynamic sepsis.
Answer to January 2017 Photo Quiz

Answer: Pneumonia with lung abscess due to serogroup 10 Legionella pneumophila. The Gram stain of the bronchoalveolar lavage (BAL) fluid smear shows intra- and extracellular Gram-negative bacilli, suggestive of aerobic bacteria. Legionella pneumophila is usually described as a pleomorphic, faintly
Hybrid neural network and regression tree ensemble pruned by simulated annealing for virtual flow metering application

Virtual flow metering (VFM) is an attractive and cost-effective solution to meet the rising multiphase flow monitoring demands in the petroleum industry. It can also augment and backup physical multiphase flow metering. In this study, a heterogeneous ensemble of neural networks and regression trees is proposed to develop a VFM model utilizing bootstrapping and parameter perturbation to generate diversity among learners. The ensemble is pruned using simulated annealing optimization to further ensure accuracy and reduce ensemble complexity. The proposed VFM model is validated using five years well-test data from eight production wells. Results show improved performance over homogeneous ensemble techniques. Average errors achieved are 1.5%, 6.5%, and 4.7% for gas, oil, and, water flow rate estimations. The developed VFM provides accurate flow rate estimations across a wide range of gas volume fractions and water cuts and is anticipated to be a step forward towards the vision of completely integrated operations.
ANÁLISIS DEL SECTOR DE LAS AGENCIAS DE VIAJES EN ESPAÑA: UNA APROXIMACIÓN DESDE LA CARACTERIZACIÓN DEL SECTOR ENTRE LAS AGENCIAS DE VIAJES TRADICIONALES Y LAS AGENCIAS DE VIAJES ONLINE

El sector de las agencias de viajes espanol esta sufriendo en los ultimos anos una importantisima transformacion. El numero de agencias se ha visto reducido de manera drastica y la composicion de la industria tambien se ha visto alterada. Por otra parte, cada vez es mayor el numero de agencias online que desplazan a aquellas que realizan su labor de intermediacion de una manera tradicional. No solo en numero sino tambien atendiendo a la cuota de mercado. El presente articulo ademas de presentar una aproximacion al criterio de division entre agencias tradicionales y online, ofrece una perspectiva de la actual composicion y reciente evolucion del sector.
Speech Enhancement in Presence of Noise using Spectral Subtraction and Wiener Filter

The process of suppressing the back ground noise in speech signals can be improved by subtraction of an estimate of the average noise spectrum from the noisy signal spectrum. The main objective of this paper is to implement and evaluate speech enhancement techniques based on spectral subtraction methods in presence of noise. The two techniques discussed in this paper are spectral subtraction filter and wiener filter. The simulation results reveal the superiority of the proposed methods for different back ground noises. KeywordsSpectral Subtraction, Additive white Gaussian Noise, Weiner Filter, Power spectrum.
Measuring the Impact of Social Media Usage for News and Social Media Usage for Interaction on Social Media Political Persuasion

The development of new forms of digital media changed the way people communicate or share information (Lee and Myers 2016). People now a days spend their days on Social Networking Sites (SNS) without deeply understanding how it is affecting their lives (Diehl et al., 2015). In the past decade, growth in the size of the Internet and World Wide Web has been largely driven by two “mega trends”: online search engines and social media channels (Xiang and Gretzel, 2010). Social Networking sites have been globally used nowadays for many purposes. It started as a platform to communicate, to stay in touch with friends or acquaintances, to meet new people, but now it has many other usages. This study will focus on the role of social media and its encouragement to participate in politics in Egypt. Nowadays, social media platforms have a huge effect on the political behavior and attitudes of citizens (Thelwall, 2008), especially in the Egyptian context. After the Arab Spring in 2011, Facebook and Twitter, or Social Networking Sites in general, proved to have a huge effect on politics and political change (Lin and Lu, 2011). The link between Social media and politics or the use of Social media by politicians was examined in many researches (Diehl et al., 2015; Wang, 2012; Lee and Myers 2016). The research have shown that social media is now a tool to change political behavior, and motivated many people to be more involved or to express their political opinions (Diehl et al., 2015). The Internet and its social media platforms form many political debates, where individuals express their views that alter other people‟s minds (Lee and Myers 2016). In addition, the Internet and its social media platforms create availability of political information, making it easier for all users to ABSTRACT
Coccidioidal pulmonary cavitation.

1. Two hundred eleven cases of coccidioidal pulmonary cavitation have been reviewed. 2. Cavitation is found in about 2 per cent of hospitalized patients with coccidioidomycosis. 3. Fifty-four per cent of these patients were asymptomatic and cavitation was detected on routine chest roentgenograms. 4. Eighty-six per cent of the patients had a single cavity and 14 per cent had multiple cavities. Of those with unilateral disease, 54 per cent were on the right side and 46 per cent on the left side. Ten patients, or 5 per cent of the total, had bilateral involvement. 5. Fifty-four per cent of the patients had positive coccidioidin skin tests and 82 per cent had positive coccidioidal serologic studies. Sixty-four per cent had positive sputum cultures for C. immttis. 6. Non-surgical and surgical management of coccidioidal pulmonary cavities have been compared. In the former group, half of the cavities closed spontaneously although 25 per cent of the patients had occasional hemoptysis which was usually slight. 7. Of the 108 patients treated with resectional surgery, two died postoperatively, 30 per cent developed postoperative bronchopleural fistulae, and 18 per cent developed new coccidioidal cavities postoperatively. 8. On the basis of the present study, a conservative, non-surgical regimen appears to be most desirable for the treatment of coccidioidal cavitation unless (a) the cavity is peripheral and has enlarged significantly, or (b) there have been recurrent severe hemoptyses.
Traffic Aware Inter-Layer Contact Selection for Multi-Layer Satellite Terrestrial Network

Satellite networks form part of the modern mobile network. In multi-layer satellite-terrestrial networks, Contact Graph Routing (CGR) enables to calculate an efficient delivery path which depends on the contact information configured in the contact plan. Due to the rapid relative motion between satellites which belong to different layers, the inter-layer contacts can suffer frequent disruption. In order to keep the integrity of the network, the inter-layer contact must be carefully selected to maintain connectivity yet avoid congestion. In this paper, we propose a traffic aware inter-layer contact selection method (TACS) by considering the flow situation of the associated nodes which contains the queue size, flow size, the number of connected nodes and the contact duration. We verify the performance of the proposed design in our Identifier/Locator (ID/Loc) split based satellite- terrestrial network testbed with 95 simulation nodes. Experiments show that the proposed design is able to achieve balanced flow distribution among MEO layer, improve the delivery ratio and reduce the delivery delay.
Challenges to the implementation of a nationwide electronic prescribing network in primary care: a qualitative study of users' perceptions

BACKGROUND AND OBJECTIVE The objective of this study was to identify physicians' and pharmacists' perceptions of the challenges and benefits to implementing a nationwide electronic prescribing network linking medical clinics and community pharmacies in Quebec, Canada. METHODS Forty-nine people (12 general practitioners, 2 managers, 33 community pharmacists, and 2 pharmacy staff members) from 40 points of care (10 primary care clinics (42% of all the connected sites) and 30 community pharmacies (44%)) were interviewed in 2013. Verbatim transcripts were analyzed using thematic analysis. RESULTS A low level of network use was observed. Most pharmacists processed e-prescriptions by manual entry instead of importing electronically. They reported concerns about potential errors generated by importing e-prescriptions, mainly due to the instruction field. Paper prescriptions were still perceived as the best means for safe and effective processing of prescriptions in pharmacies. Speed issues when validating e-prescription messages were seen as an irritant by physicians, and resulted in several of them abandoning transmission. Displaying the medications based on the dispensing data was identified as the main obstacle to meaningful use of medication histories. CONCLUSIONS Numerous challenges impeded realization of the benefits of this network. Standards for e-prescription messages, as well as rules for message validation, need to be improved to increase the potential benefits of e-prescriptions. Standard drug terminology including the concept of clinical medication should be developed, and the implementation of rules in local applications to allow for the classification and reconciliation of medication lists from dispensing data should be made a priority.
Analysis of the Abscopal Effect With Anti-PD1 Therapy in Patients With Metastatic Solid Tumors

Abscopal effect is a rare phenomenon characterized by tumor regression of untreated metastatic lesions after a local therapy (eg, radiotherapy). We studied the probability of abscopal effect with radiotherapy associated with anti-programmed death cell 1 (PD1) therapy after progression on anti-PD1. This study is a retrospective analysis of patients treated with nivolumab or pembrolizumab for melanoma, non–small cell lung cancer (NSCLC) and renal cancer at Antônio Ermírio de Moraes Oncology Center, Brazil. To be eligible for this analysis, patients must have had unequivocal evidence of disease progression on anti-PD1 therapy and subsequent radiotherapy for any tumor site while still receiving anti-PD1. The abscopal effect was characterized as a response outside the irradiated field after radiotherapy plus anti-PD1. Sixteen patients were evaluated, including 12 metastatic melanoma, 2 metastatic NSCLC, and 2 metastatic renal cell carcinoma. The median time to disease progression on anti-PD1 was 3 months. The radiotherapy field included lung, lymph nodes, and bones, with a median total dose of 24 Gy (1–40 Gy), usually in 3 fractions (1–10 fractions). Three patients with melanoma developed an abscopal effect at a rate of 18.7% (25% among melanoma patients). Of note, one of them achieved a remarkable complete response lasting >6 months. Three patients with melanoma obtained a significant local response after radiotherapy, despite no response in distant metastases. Eleven patients presented disease progression after radiotherapy. No increased toxicity was observed. In conclusion, no patients with NSCLC or renal cancer showed abscopal effect, but 25% of patients with melanoma showed regression of nonirradiated lesions when anti-PD1 was continued after radiation to a tumor site that had progressed on anti-PD1 monotherapy.
Identification of Promoters Recognized by RNA Polymerase-σE Holoenzyme from Thermus thermophilus HB8

ABSTRACT Thermus thermophilus σE, an extracytoplasmic function σ factor from the extremely thermophilic bacterium Thermus thermophilus HB8, bound to the RNA polymerase core enzyme and showed transcriptional activity. With the combination of in vitro transcription assay and GeneChip technology, we identified three promoters recognized by σE. The predicted consensus promoter sequence for σE is 5′-CA(A/T)(A/C)C(A/C)-N15-CCGTA-3′.
Revisión de materiales de relleno

Los materiales de relleno tienen mas de un siglo en uso. Durante este periodo de tiempo se ha aprendido mucho acerca de sus riesgos y aplicaciones. Este articulo aborda las principales caracteristicas de la mayoria de los rellenos que hay en el mercado, tanto de materiales de relleno temporales como el acido hialuronicoo el colageno, materiales de relleno semipermanentes como la hidroxiapatitia de calcio, o el acido polilactico, y materiales de relleno permanentes como el silicon, hidrogel de poliacrilamida , hidrogel de polialquilimida y microesferas de polimetil-metacrilato
The effect of sampling frequency and front-end bandwidth on the DLL code tracking performance

The synchronization of the received pseudorandom (PRN) cod e an the local generated replica is fundamental to compute user position i n Global Navigation Satellite System (GNSS) receivers. The more accurate c orr lation output and Delay Locked Loop (DLL) code tracking error are describe d in this paper from the hardware receiver point of view. Estimation is base d on the number of samples per code chip and the residual code phase of the cod e Numerical Controlled Oscillator (NCO) after a code chip is generated. The theoretical as well as experiment results show that the relation between the sampling frequency and front-end filter bandwidth has a strong influence i the code tracking. Increasing the sampling frequency can help to improve t he DLL tracking performance if and only if the front-end bandwidth is much sm aller than the sampling frequency. The more accurate estimation of the cor relation and the DLL tracking error, proposed in this paper, can generally ap ply on precisely modeling GNSS receiver baseband signal processing.
Effect of maternal restraint stress during gestation on temporallipopolysaccharide-induced neuroendocrineand immune responses of progeny

The impact of gestational dam restraint stress on progeny immune and neuroendocrine temporal hormone responses to lipopolysaccharide (LPS) challenge was assessed. Maternal stress (5-min snout snare restraint stress during days 84 to 112 of gestation) increased (P 0.05) the magnitude of tumor necrosis factor (TNF), interleukin-6, epinephrine (E), norepinephrine, and serum amyloid A (SAA) production following LPS infusion in the offspring. Moreover, these effects appear to be dependent on gender for TNF, E, and cortisol production. However, maternal stress did not affect (P 0.05) the normalization of proinflammatory cytokines or neuroendocrine hormones produced following LPS. Collectively, these results indicate that maternal stress impacts aspects of the proinflammatory cytokine and stress hormone response in their progeny following LPS dosing of the offspring. This response is potentially responsible in part for the resultant changes to SAA production. Because several of the changes observed here are dependent on pig gender, these results are also the first evidence that inherent epigenetic factors coupled with maternal stress impact the cumulative response to stress and LPS in young pigs. © 2011 Elsevier Inc. All rights reserved.
Similarity Evaluation and Shape Feature Extraction for Character Pattern Retrieval to Support Reading Historical Documents

We have many historical documents written in over 1,000 years ago. Shape features of character patterns on the documents are unstable or missing because most of the documents have been stained and degraded deeply. Digital archives of the documents with accurate character pattern retrieval methods are helpful for archaeologists and historians. In this paper, we propose a similarity evaluation method for character patterns with missing shape parts. It collaboratively works with non-linear normalization for such patterns, and modifies the templates for each trial of the retrieval efficiently. In the experiences using 4,911 Kanji (Chinese origin) character patterns from the Japanese historical documents called mokkans, the method shows improvements of the retrieval accuracy. Also, we present a simple implementation of gradient feature extraction to compare the chain code feature with the gradient feature in the retrieval. As the result, the gradient feature works better than the chain code feature.
Proposal and evaluation of a task migration protocol for NoC-based MPSoCs

Task migration is a well-known strategy adopted in distributed systems for load balancing. but the adoption of such strategy in NoC-based MPSoC is scarce in the literature. This paper proposes a complete task migration protocol for NoC-based MPSoCs. The migration transfers the task code, data and context to another PE. The paper presents the communication strategy to ensure coherence in the messages delivery, the heuristic to compute the new task location, and the procedure to inform the new task position. Results evaluate the cost of the task migration using a real MPSoC (described in synthesizable VHDL), demonstrating that the cost to migrate a given task has a small impact in the system performance, enabling its use to improve the overall system performance.