Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFICACY OF PRAZIQUANTEL FOR TREATMENT OF REPEAT INFECTION OF Opisthorchis viverrini IN HAMSTER

The human liver fluke, Opisthorchis viverrini infects several million people in Thailand. Chronic opisthorchiasis combined with nitrosamine ingested with food frequently leads bile duct cancer, cholangiocarcinoma (CCA). Repeated infection by O. viverrini increases hepatobiliary disease as well as increases the risk of CCA. Praziquantel (PZQ) is the drug of choice for treatment of opisthorchiasis. Whereas PZQ is considered safe to use, recent reports have cautioned that repeated use might influence the risk of liver fluke infectioninduced CCA. Therefore, the efficacy of repeated treatment with PZQ warranted evaluation. Here the efficacy of PZQ treatment was investigated in hamsters repeatedly infected with O. viverrini and in hamsters both infected with O. viverrini and exposed to the carcinogen dimethylnitrosamine (DMN). Experimental hamsters were infected with O. viverrini and treated two times with 300 mg/kg of PZQ. Other hamsters were infected with O. viverrini as well as provided with drinking water that contained 12.5 ppm DMN, following by two treatments with PZQ. As controls, uninfected hamsters, uninfected hamsters treated with PZQ, and uninfected hamsters treated with both PZQ with DMN were included. Histopathology of hepatobiliary tissues was examined, specifically for infiltration of white blood cells, proliferation of cholangiocytes and fibrosis. The pathology including inflammation, bile duct cell proliferation and liver fibrosis decreased 1 Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. E-mail: sophi_gift@hotmail.com; thewa_la@kku.ac. th 2 Department of Veterinary Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. E-mail: sirikach@kku.ac. th 3 Tropical Disease Research Laboratory, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. E-mail: banchob@kku.ac. th 4 Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA. E-mail: pbrindley@email.gwu. edu * Corresponding author Suranaree J. Sci. Technol. 23(1):17-24 18 Efficacy of Praziquantel for Treatment of Repeat Infection of O. viverrini in Hamster significantly by one week following treatment with PZQ. Following repeated infection with O. viverrini and exposure to DMN, and treatment with PZQ, disease was less marked compared to hamsters infected twice with O. viverrini but without treatment with PZQ. Severe disease manifested in hamsters with repeated liver fluke infection without PZQ treatment. Differences in pathology were not evident among the control hamsters – noninfected hamsters, uninfected hamster receiving PZQ only and uninfected hamsters treated with both PZQ with DMN. These findings confirmed the efficacy of PZQ for treatment of opisthorchiasis.
Dental Avulsions: If Immediate Replantation was Impossible

Traumatic dental injuries represents a serious dental health problem especially among children and young adults. One of them is tooth avulsion, “Avulsion” is used to describe a situation in which a tooth has been removed from its socket as a result of severe trauma. As well as teeth (the neurovascular bundle at the root apex, the cement layer of the tooth) and environmental support tissues (the periodontal ligament (PDL) fibers, alveolar bone, and the gingiva) are all damaged seriously with tooth avulsion [1]. Incidence of avulsion account for 0.5% to 16% of traumatic injuries in the permanent dentition [2]. Maxillary incisors are most commonly affected. Tooth avulsion has been puzzling for many pediatric dentists. Because the management of avulsion is effected several factors alone either or together. These factors are root development, extra-alveolar period, storage medium, the patient’s age and medical status, development of the dentition, concomitant dentoalveolar injuries and type and duration of splint. Replantation is the only treatment choice, but careful assessment of the cases is most importance for the avulsed tooth to be successfully replanted. The successful treatment outcome after replantation of the avulsed tooth is pulp survival and periodontal healing and minimal bacterial contamination [3]. Especially extra-alveolar period and storage medium determine the success of replantation directly. The time until replantation ranged between 15 minutes and 10 hour in some studies [1,4]. The extra-alveolar period should ideally be a maximum of 20 minutes to 30 minutes for the best prognosis for replantation [2,5]. However, ideal timing for immediate replantation is not always possible, thus late replantation is applied. Some factors such as lack of knowledge of the people about management of an avulsed tooth, unavailability of finding appropriate storage medium and bleeding due to soft tissue injury mask the loss of teeth have not allow this situation always.
Antioxidant Property , Tocopherol Contents and Tyrosinase Inhibitory Capacity of Rice Bran during Storage

Rice bran, a low-valued coproduct obtained from rice processing, represents a potential source of valueadded healthy products. Rice bran contains several phenolic compounds as well as vitamin E derivatives that have reported health benefits. The effects of storage time and temperature on phenolic, antioxidant and tyrosinase inhibitory of rice cv. Khaw Dawk Mali were investigated. High temperature and longer storage time (7 months) reduced the L (lightness) value and increased the b (yellowness) value a (redness) value. The phenolic content of extracts during 7 month storage obtained ranged from 1.10 to 3.52 mg/g and 1.42 to 3.52 mg/g of stored rice at 2°C and 37°C, respectively, with corresponding tyrosinase inhibitory capacities. The tyrosinase inhibitory property was determined in term of IC50 (mg/g). IC50 of non-stored rice, 7 month stored rice at 25°C and storage for 7months at 37°C were 1.36, 9.57 and 8.64 mg/g, respectively. The relationship between tyrosinase inhibitory capacities and total phenolic content was highly significant at P< 0.05. The antioxidant capacity of the rice bran aqueous extracts were determined by 2,2-azino-bis-(3 ehylbenzothiazoline-6-sulphonicacid) diammonium salt (ABTS) and 1,1diphynyl-2-picrylhydrazyl (DPPH) free radical scavenging radical cation antioxidant capacity in mg extract/ml. The lipid fraction of rice brans were analyzed for tocopherol and tocotrienol contents by reversed-phase HPLC. Tocopherol contents from rice bran were measured. The tocopherol contents of the rice bran extracts obtained at 25 °C and 37°C storage were 0.04 mg/g (w/w). The results showed that storage time at 25°C and 37°C caused decrease of extractable phenolic contents, antioxidant activities and tyrosinase inhibitory property of the rice bran however the rice bran of 7month stored rice at 37°C contained phenolic contents, antioxidant activities and tyrosinase inhibitory property were higher than those of the rice bran of 7month stored rice at 25°C.
Towards A Well-Secured Electronic Health Record in the Health Cloud

The major concerns for most cloud implementers particularly in the health care industry have remained data security and privacy. A prominent and major threat that constitutes a hurdle for practitioners within the health industry from exploiting and benefiting from the gains of cloud computing is the fear of theft of patients health data in the cloud. Investigations and surveys have revealed that most practitioners in the health care industry are concerned about the risk of health data mix-up amongst the various cloud providers, hacking to comprise the cloud platform and theft of vital patients’ health data.An overview of the diverse issues relating to health data privacy and overall security in the cloud are presented in this technical report. Based on identifed secure access requirements, an encryption-based eHR security model for securing and enforcing authorised access to electronic health data (records), eHR is also presented. It highlights three core functionalities for managing issues relating to health data privacy and security of eHR in health care cloud.
CLIC 4 translocation 25 Spatiotemporal regulation of CLIC 4 , a novel player in the G α 13-RhoA signaling pathway

CLIC4 (“Chloride Intracellular Channel” 4) is a soluble protein structurally related to omega-type glutathione-S-transferases (GSTs) and implicated in various biological processes, ranging from chloride channel formation to morphogenesis. However, the function of CLIC4 and whether it is regulated remain unclear. Using time-lapse microscopy, we show that G13-coupled receptor agonists, such as lysophosphatidic acid and thrombin, trigger the rapid translocation of CLIC4 from the cytosol to the activated receptor at the plasma membrane. CLIC4 recruitment is transient (lasting 5-10 min) and strictly dependent on G(α)13, RhoA activation and F-actin integrity. CLIC4 does not appear to enter the plasma membrane or to modulate chloride currents. CLIC4 translocation requires at least six conserved residues, including reactive Cys35, whose equivalents are critical for substrate binding in omega-GSTs. Our results show that CLIC4 is regulated by G13-linked RhoA pathway to be targeted to G13-coupled receptor complexes at the plasma membrane, and they suggest that CLIC4 binds an as-yet-unknown substrate in a manner analogous to GST-substrate interaction.
Experimental investigation of EM noise environment surrounding detector systems in swedish railways

The close environment of railway tracks is heavily polluted by electromagnetic noise from the railway system itself. The reliability of railway signalling, communication, and control systems depends on good immunity to electromagnetic noise. There are sometimes false detector signals indicating non-existing flat wheels and ghost trains. A possible reason for detector failures is interference by transient voltage peaks in the detector system. Thus characterisation has been made of the electromagnetic environment around the detector system located at the track. The investigation shows that the typical electromagnetic environment is a combination of broadband low-level noise, and rare fast transients of potentially harmful amplitudes.
Local measurement of venous saturation in tissue with noninvasive near-infrared respiratory oximetry

We present preliminary results of non-invasive, near-infrared measurements of venous saturation (SvO2) on the leg muscle of three anesthetized piglets. We have quantified the local SvO2 by analyzing the optical spectrum of the amplitude of the absorption oscillations synchronous with breathing. To induce a variation in the muscle SvO2, we performed measurements during a protocol involving a cyclic change in the fraction of oxygen inspired by the piglet over the range 10-100% (by volume). In all three piglets, we have found a good agreement between the SvO2 values measured non-invasively with near-infrared spectroscopy (NIRS) and those measured invasively by the analysis of venous blood samples.
Automated Virtual Navigation and Monocular Localization of Indoor Spaces from Videos

3D virtual navigation and localization in large indoor spaces (i.e., shopping malls and offices) are usually two separate studied problems. In this paper, we propose an automated framework to publish both 3D virtual navigation and monocular localization services that only require videos (or burst of images) of the environment as input. The framework can unify two problems as one because the collected data are highly utilized for both problems, 3D visual model reconstruction and training data for monocular localization. The power of our approach is that it does not need any human label data and instead automates the process of two separate services based on raw video (or burst of images) data captured by a common mobile device. We build a prototype system that publishes both virtual navigation and localization services for a shopping mall using raw video (or burst of images) data as inputs. Two web applications are developed utilizing two services. One allows navigation in 3D following the original video traces, and user can also stop at any time to explore in 3D space. One allows a user to acquire his/her location by uploading an image of the venue. Because of low barrier of data acquirement, this makes our system widely applicable to a variety of domains and significantly reduces service cost for potential customers.
Intelligent Adaptive Control of an One Link Manipulator Using Self-Tuning Regulator

For overcomes several shortcomings of the inverse control design to controlling nonlinear systems using the neural networks as the controller based self tuning regulator. The one link manipulator parameters are estimated online and are used to update the weights of the RBFNN. The weight update equations are derived based on the least mean squares principle. The RBFNN virtually models the inverse of the plant and thus the output tracks the reference trajectory. The proposed algorithm is successfully verified using simulations. Then, this paper compared its result with the outcome of using proportional-plus-integral feedback (PI) self tuning regulator.
Effect of Immobilization Stress on the Cytoskeletal Intermediate Filaments of Rat Stomach and the Possible Curative Role of Diazepam

The present study is planned to investigate the effect of immobilization-stress for 30 days on the cytoskeletal intermediate filaments of the rat stomach and the possible curative role of diazepam immunohistochemically. The study was conducted on forty adult male albino rats weighing 110 ± 5 g were used and divided equally into four groups (10 animals each), group (1) served as control rats; group (2) treated unstressed rats with diazepam only for 30 days; group (3) served as immobilizedstressed rats for 2 hrs / day for 30 days and group (4) served as immobilizedstressed rats treated with diazepam (therapeutic dose, 0.1mg /kg b.w.) for 30 days obtained results revealed a significant increase in sera cortisol of the stressed – rats for 30 days. The cytokeratin of cytoskeletal intermediate filaments after stress revealed a marked intense immunoreactivity at the apical part and lateral borders of the surface mucous cells, mucous neck cells, parietal and chief cells. The vimentin demonstrated intensive immunoreactivity in the lamina propria and the blood vessels. Treatment of the stressed-rats with diazepam showed obviously improvements and amelioration in the cytoskeletal intermediate filaments of the stomach. In concluion; stress should be avoided and supported the using diazepam as a curative drug to improve the disturbances in the stomach intermediate filaments caused under the effect of stress. [Nabila I. El – Desouki, Amal I. El-Refaiy, Gabry M. Sayed, Mona A.Ibrahim, and Heba N. Mohamed. The Effect of Immobilization Stress on the Cytoskeletal Intermediate Filaments of Rat Stomach and the Possible Curative Role of Diazepam. Life Sci J 2013; 10 (2): 2211-2219] (ISSN:1097-8135). http://www.lifesciencesite. com. 308
Lipolytic Effect of Eumicrotremus orbis Water Extracts in Differentiated 3T3-L1 Adipocytes

In this study, we investigated the effects of Eumicrotremus orbis water extracts (EOWE) on lipolysis in differentiatied 3T3-L1 adipocytes and its mechanism. It was observed that there was no cytotoxicity for adipocytes of EOWE. The content of glycerol released in cell culture medium increased dependent on sample concentration. In differentiated 3T3-L1 adipocytes treated EOWE, hormone sensitive lipase (HSL) and phosphorylated HSL (p-HSL) protein level increased by approximately 3.43 and 1.77 times as compared to the controls. But, adipose triglyceride lipase (ATGL) protein level did not effect as compared to the controls. Treated EOWE inhibited the protein expression of perilipin A. In other word, it is judged to be due to, a content of glycerol released in cell culture medium increased through not only increase of HSL, p-HSL and p-PKA protein level, but inhibit of perilipin A. Therefore, our results suggest that EOWE may induce lipoylsis by increasing the protein levels of HSL, p-HSL and p-PKA.
Kommunikationsdatenbasierte, dezentrale Lichtsignalsteuerung in städtischen Netzen

Die Zunahme der Verkehrsnachfrage im motorisierten Individualverkehr in urbanen Ballungsraumen fuhrt zu vielfaltigen Verkehrsproblemen (u.a. verlangerte Reisezeiten, erhohte Emissionen). Die Qualitat des Verkehrs-flusses in stadtischen Netzen wird von der Gute der Lichtsignalsteuerungen wesentlich beeinflusst. Eine Mog-lichkeit, den negativen Auswirkungen entgegenzuwirken, besteht in der netzweiten Optimierung. Technische Fortschritte in der drahtlosen Kommunikation und GPS-Lokalisierung ermoglichen in der Zukunft eine standardisierte drahtlose Kommunikation zwischen Fahrzeugen untereinander und mit Infrastrukturelementen. Wesentlicher Vorteil dieser Technologie ist die fruhzeitige und kontinuierliche Detektion von Fahrzeugen in den Zu- und Abflussen von Lichtsignalanlagen. Kontinuierlich ubermittelte Positions- und Geschwindigkeitsdaten (V2I-Daten) vom Fahrzeug zu einem Access Point an der Lichtsignalanlage stellen einen deutlichen Informationsgewinn dar. Im Rahmen der Dissertation wurde ein azyklisches, dezentrales Steuerungsverfahren entwickelt, welches das neue Datenpotential an V2I-Daten nutzt, um den Verkehrsfluss in stadtischen Netzen zu optimieren. Es erfolgt dabei kein Informationsaustausch zwischen benachbarten Knotenpunkten oder einer zentralen Ebene. Koordinierungs- und Priorisierungsstrategien konnen nachweislich umgesetzt werden. Die Steuerung jedes Knotenpunkts erfolgt phasenbasiert. Die Anzahl der Phasen und -ubergangen ist unbeschrankt. Zu jedem Optimierungsintervall von ? t=5s werden anhand von V2I-Daten die Warteschlangen fur jede Phasenkombination fur die nachsten 20s prognostiziert. Entsprechend der Zielfunktion wird die Phasenfolge mit der minimalen Gesamtruckstaulange ausgewahlt und umgesetzt. Wesentlichen Einfluss auf die Qualitat des Verfahrens hat der Anteil an kommunikationsfahigen Fahrzeugen. Daher wurde eine Methode in das Verfahren integriert, die anhand von wenigen V2I-Daten eine zuverlassige Schatzung der Ruckstaulangen sicherstellt.
P 8 . 8 Flavonoid-induced changes in oxygen consumption and mitochondrial membrane potential in isolated endothelial mitochondria

The impact of an endurance training (ET) on the bioenergetics of muscle mitochondria under hypothermia (25oC), normothermia (35oC), and hyperthermia (42oC) will be discussed by the example of rat skeletal mitochondria. In skeletal muscles, ET leads to considerable elevations of mitochondrial biogenesis and oxidative capacity, which are accompanied by several qualitative temperature-dependent changes at the mitochondrial bioenergetics level. In skeletal muscle mitochondria, ET (i) augments the phosphorylation rate and coenzyme Q (Q) level, (ii) significantly increases reactive oxygen species (ROS) production (and Q reduction level) in non-phosphorylating mitochondria, (III) decreases ROS production (and Q reduction level) in phosphorylating mitochondria, and (iv) upregulates mitochondrial capacity to oxidize the lipid-derived fuels (palmitoylcarnitine and glycerol-3-phosphate). The ET-induced decrease in mitochondrial uncoupling, including uncoupling protein 3 (UCP3)-mediated proton leak, may explain the increased ROS production (in non-phosphorylating mitochondria) and enhanced oxidative phosphorylation efficiency. Moreover, ET magnifies the hyperthermiainduced increase in oxidative capacity and attenuates the hyperthermia-induced decline in oxidative phosphorylation efficiency and ROS formation of non-phosphorylating mitochondria. Thus, ET increases the bioenergetic efficiency of skeletal muscle mitochondria. The ET-induced quantitative and qualitative changes in muscle mitochondria may be important for maintaining muscle cell energy homeostasis, muscle cell signalling, and exercise performance, especially at hyperthermia.
Light and gas confinement in hollow-core photonic crystal fibre based photonic microcells

We review the recent progress on the understanding of optical guidance mechanisms in hollow-core photonic crystal fibres, and on the quantum and nonlinear optical applications of photonic microcells based on this fibre form. Two classes of hollow-core photonic crystal fibre are identified: one guides via a photonic bandgap and the other guides by virtue of an inhibited coupling between core and cladding mode constituents. For the former fibre type, we explore how the bandgap is formed using a photonic analogue of the tight-binding model and how it is related to the anti-resonant reflection optical waveguide guidance. For the second type of fibre, which can guide over a broad wavelength range, we examine the nature of the inhibited coupling. We describe a technique for the fabrication of photonic microcells that can accommodate vacuum pressures, and we finish by showing the latest results on electromagnetically induced transparency in a rubidium filled hollow-core photonic crystal fibre, the CW-pumped hydrogen Raman laser and the generation of multi-octave spanning stimulated Raman scattering spectral combs.
REFINEMENT OF THE CRYSTAL STRUCTURE OF VÄYRYNENITE

Vayrynenite, (Mn2+0.78Fe2+0.23Mg0.01)Be(PO4)(OH0.92F0.08), is monoclinic, a 5.4044(6), b 14.5145(12), c 4.7052(6) A, β 102.798(9)°, V 359.91(7) A3, space group P 21/ a , Z = 4. The structure was refined to an R index of 1.5% based on 1001 observed [| F o| > 5σ F ] for reflections measured with Mo K α X-radiation using a single-crystal diffractometer. In the structure of vayrynenite, (Beφ4) tetrahedra connect to adjacent (Beφ4) tetrahedra by corner-sharing of anions in a zigzag pattern to form a chain that extends in the a direction. This chain is decorated along its periphery by (PO4) tetrahedra that corner-share with one O atom from each of two different (Beφ4) tetrahedra to form ribbons along the c axis. These [Be2(OH)2(PO4)2]n4n− ribbons, which somewhat resemble the [Be2(OH)2(SiO4)2] chains in euclase, AlBe(SiO4)(OH), are linked in the b direction by (Mn2+,Fe2+) in octahedral coordination. The resultant (001) sheets are linked to adjacent sheets in the c direction by corner-sharing of O atoms between (PO4) tetrahedra and {(Mn,Fe) φ6}octahedra, and by hydrogen bonds. The hydrogen position was determined directly, and a sensible hydrogen-bonding scheme established. The connectivity of the (Beφ4– T φ4) ( T = Si,P) chains in Be minerals is examined, and arranged in a hierarchy of increasing topological complexity.
Child Detachment as a Correlate of Social Well-Being of Orphaned Children in Ibadan and Abeokuta, Nigeria

This study investigated child detachment as a correlate of social well-being among orphaned children from selected orphanages in Ibadan and Abeokuta. The study adopted a descriptive survey research design. A total of 350 respondents were purposively selected from the four orphanages using purposive sampling technique. The study found that the support and care received by the respondents have positive significant effects on their physical well-being and self-esteem. The study also showed that there is high prevalence of paternal death and loss of bread winners in households which has economic implication on the lives of the children. The findings showed that institutional care has beneficial effect on the lives of orphaned children especially in the urban setting as against the rural setting where extended family is still functioning. The study made some recommendations which include staff development training for proprietors and workers in orphanages to provide family-like environment for orphans in their custody. DOI: 10.5901/mjss.2015. v6n3s2p113