Miracle-dz/UniFAR-FTUs huggingface dataset:
Sequence of interleukin‐2 isolated from human placental poly A+ RNA: Possible role in maintenance of fetal allograft

There are several cell types within the placenta that produce cytokines which can contribute to the regulatory mechanisms that ensure normal pregnancy. The immunological milieu at the maternofetal interface is considered to be crucial for survival of the fetus. Interleukin‐2 (IL‐2) is expressed by the syncytiotrophoblast, the cell layer between the mother and the fetus. IL‐2 appears to be a key factor in maintenance of pregnancy. Therefore, it was important to determine the sequence of human placental interleukin‐2. Direct sequencing of human placental IL‐2 cDNA was determined for the coding region. Subclone sequencing was carried out for the 5′‐ and 3′‐untranslated regions (5′‐UTR and 3′‐UTR). The 5′‐UTR for human placental IL‐2 cDNA is 294 bp, which is 247 nucleotides longer than that reported for cDNA IL‐2 derived from T cells. The sequence of the coding region is identical to that reported for T cell IL‐2, while sequence analysis of the polymerase chain reaction (PCR) product showed that the cDNA from the 3′ end was the same as that reported for cDNA from T cells. Human placental IL‐2 cDNA is 1,028 base pairs (excluding the poly A tail), which is 247 bp longer at the 5′ end than that reported for IL‐2 T cell cDNA. Therefore, the extended 5′‐UTR of the placental IL‐2 cDNA may be a consequence of alternative promoter utilization in the placenta. © 1996 Wiley‐Liss, Inc.
A ribosome‐associated peptidyl‐prolyl cis/trans isomerase identified as the trigger factor.

Peptidyl‐prolyl cis/trans isomerases (PPIases) are enzymes that catalyse protein folding both in vitro and in vivo. We isolated a peptidyl‐prolyl cis/trans isomerase (PPIase) which is specifically associated with the 50S subunit of the Escherichia coli ribosome. This association was abolished by adding at least 1.5 M LiCl. Sequencing the N‐terminal amino acids in addition to three proteolytic fragments totalling 62 amino acids revealed that this PPIase is identical to the E.coli trigger factor. A comparison of the amino acid sequence of trigger factor with those of other PPIase families shows little similarities, suggesting that trigger factor may represent an additional family of PPIases. Trigger factor was purified to homogeneity on a preparative scale from E.coli and its enzymatic properties were studied. In its activity towards oligopeptide substrates, the trigger factor resembles the FK506‐binding proteins (FKBPs). Additionally, the pattern of subsite specificities with respect to the amino acid preceding proline in Suc‐Ala‐Xaa‐Pro‐Phe‐4‐nitroanilides is reminiscent of FKBPs. However, the PPIase activity of the trigger factor was not inhibited by either FK506 or by cyclosporin A at concentrations up to 100 microM. In vitro, the trigger factor catalysed the proline‐limited refolding of a variant of RNase T1 much better than all other PPIases that have been examined so far.
Aplasia Cutis Congenita Associated with Cutis Marmorata Telangiectatica Congenita, Atrial Septal Defect, and Epilepsy: A Newly Recognized Syndrome? -A Case Report

Aplasia cutis congenita (ACC) is a rare developmental malformation characterized by the absence of skin, and often extends to bone or dura in a localized or widespread area at birth. ACC is seen most commonly on the scalp reported up to eighty-four percent of all cases in the literature. It often manifested as a solitary lesion without other anomalies, but sometimes represented as part of a heterogenous group of disorders. We presented a case of ACC associated with cutis marmorata telangiectatica congenita, secundum atrial septal defect and epilepsy which seem not fit well with any previously recognized clinical syndrome. In addition, emphasis on pathogenesis, histopathology, and treatment strategies were also discussed.
Tetrathiomolybdate anticopper therapy for Wilson's disease inhibits angiogenesis, fibrosis and inflammation

The need for agents to lower body copper in Wilson's disease, a disease which results from copper toxicity has been the driving force for the development of the effective anticopper drugs penicillamine, trientine, zinc, and now tetrathiomolybdate (TM). Because of its rapid action, potency, and safety, TM is proving to be a very effective drug for initial treatment of acutely ill Wilson's disease patients. Beyond this, TM has antiangiogenic effects, because many proangiogenic cytokines require normal levels of copper. This has led to use of TM in cancer, where it is generally effective in animal tumor models, and has shown efficacy in preliminary clinical studies. Most recently, it has been found that TM has antifibrotic and antiinflammatory effects through inhibition of profibrotic and proinflammatory cytokines.
Online Heterogeneous Transfer by Hedge Ensemble of Offline and Online Decisions

In this paper, we study the online heterogeneous transfer (OHT) learning problem, where the target data of interest arrive in an online manner, while the source data and auxiliary co-occurrence data are from offline sources and can be easily annotated. OHT is very challenging, since the feature spaces of the source and target domains are different. To address this, we propose a novel technique called OHT by hedge ensemble by exploiting both offline knowledge and online knowledge of different domains. To this end, we build an offline decision function based on a heterogeneous similarity that is constructed using labeled source data and unlabeled auxiliary co-occurrence data. After that, an online decision function is learned from the target data. Last, we employ a hedge weighting strategy to combine the offline and online decision functions to exploit knowledge from the source and target domains of different feature spaces. We also provide a theoretical analysis regarding the mistake bounds of the proposed approach. Comprehensive experiments on three real-world data sets demonstrate the effectiveness of the proposed technique.
Probing topological electronic effects in catalysis: thiophene adsorption on NiMoS and CoMoS clusters

A general two-step theoretical approach to study electronic redistributions in catalytic processes is presented. In the first step, density functional theory (DFT) is used to fully optimize two geometries: the cluster representing the catalyst and the cluster plus adsorbed molecule system. In the second step, the converged electron density is divided into multipoles centered on atomic sites according to a distributed multipole analysis which provides detailed topological information on the charge redistribution of catalyst and molecule before and after adsorption. This approach is applied to thiophene adsorption on the 10-10 metal edge of Ni(Co)MoS catalysts and compared to the same reaction on bare MoS2. Calculated adsorption energies, geometries and multipole analysis indicate weak thiophene chemisorption on both cases. A Coulombic bond model showed that surface metal-sulfur bond strengths in Ni(Co)MoS promoted catalysts are considerably smaller than in bare MoS2, thus confirming the origin of the enhancement of hydrodesulfurization (HDS) activity in these catalysts.
Combining randomized and non‐randomized evidence in clinical research: a review of methods and applications

Researchers may have multiple motivations for combining disparate pieces of evidence in a meta‐analysis, such as generalizing experimental results or increasing the power to detect an effect that a single study is not able to detect. However, while in meta‐analysis, the main question may be simple, the structure of evidence available to answer it may be complex. As a consequence, combining disparate pieces of evidence becomes a challenge. In this review, we cover statistical methods that have been used for the evidence‐synthesis of different study types with the same outcome and similar interventions. For the methodological review, a literature retrieval in the area of generalized evidence‐synthesis was performed, and publications were identified, assessed, grouped and classified. Furthermore real applications of these methods in medicine were identified and described. For these approaches, 39 real clinical applications could be identified. A new classification of methods is provided, which takes into account: the inferential approach, the bias modeling, the hierarchical structure, and the use of graphical modeling. We conclude with a discussion of pros and cons of our approach and give some practical advice. Copyright © 2014 John Wiley & Sons, Ltd.
Prevalence and prognostic value of hepatic histological alterations in patients with Crohn’s disease

Abstract Variable degrees of liver histological changes in patients with Crohn’s disease (CD) have been reported. Objective. To evaluate the liver histological alterations and their prognostic significance in patients affected by CD without abnormalities of liver biochemical parameters and ultrasound features. Material and Methods. A prospective, single-blind study, including 35 consecutive patients with CD that underwent bowel resection with a contemporary performance of liver biopsy from 1992 to 2003. Exclusion criteria: the presence of standard causes of liver disease, such as alcohol consumption exceeding 20 g/day, primary sclerosing cholangitis, viral infections, celiac disease, metabolic syndrome and alterations of the metabolism. Patients were followed up with regular evaluation of hepatic cytolysis, cholestasis, synthesis and ultrasound performance. After a mean interval of 14 years (from May to December 2013), liver fibrosis was assessed by Fibroscan®. Results. Histological alterations were shown in 60% of patients, without serious liver injuries (no case of inflammation or significant fibrosis). Fibroscan® was performed in 33 subjects and no significant changes were observed (mean value of liver stiffness: 5.2 ± 1.2 kPa). The minimal microscopic damage did not evolve either in patients with a normal histology or in those with an altered histology at baseline (p = 0.9). Only patients who took azathioprine had a statistically significant increase of liver stiffness values (5.7 ± 1.5 kPa vs 4.7 ± 1.3 kPa, p = 0.017). Conclusions. Patients with CD do not need additional examinations compared to the general population, unless clinical or biochemical abnormalities are found.
Limitations of axis II in diagnosing personality pathology in clinical practice.

OBJECTIVE DSM-IV's axis II is limited to severe personality disturbances, posing difficulty for diagnosing less severe but nonetheless clinically significant personality pathology. The authors examined the percentage of patients treated in clinical practice for personality pathology who are diagnosable with DSM-IV. METHOD Psychiatrists and psychologists from a random national sample provided diagnostic data on 714 patients treated for enduring, maladaptive personality patterns. RESULTS Only 39.4% of the patients had diagnosable axis II disorders. This percentage was relatively stable across clinicians' theoretical orientations and did not vary substantially when axis I diagnosis was controlled for. CONCLUSIONS DSM-IV cannot be used to diagnose most patients being treated for personality problems. The range of axis II should be broadened to encompass the range of personality pathology seen in clinical practice.
AN ACCURATE RECOGNIZER FOR BASIC ARABIC SOUNDS

This paper is part of an ongoing work aiming to build an accurate Arabic sounds recognizer for teaching and learning purposes. Early phases of this work were dedicated to the development of a particular sound database from recitations of the Holy Quran to cover classical Arabic sounds; speech signals of this sound database were manually segmented and labelled on three levels: word, phoneme, and allophone. Next, two baseline recognizers were built to validate the speech segmentation on both phoneme and allophone levels and also to test the feasibility of the sounds' recognition intended target. This current phase considers the development of an elaborated recognizer, by considering the basic sounds and looking for their distinctive features (e.g. duration, energy, etc.) to determine which ones will be particularly helpful to identify the phonological variation of the basic sound. Here, we present the first results of the basic sounds recognition obtained so far.
Analisis Penggunaan Garam Low Sodium Salt terhadap Kadar Natrium dan Daya Terima Mandai Goreng

Peningkatan tekanan darah atau biasa disebut hipertensi sampai saat ini masih merupakan penyebab utama dan faktor risiko yang penting terhadap penyakit kardiovaskular, serebrovaskular, penyakit jantung, dan gagal ginjal. Tujuan umum dari penelitian ini menganalisis kandungan natrium dan daya terima mandai goreng rendah natrium sebagai makanan alternatif bagi penderita hipertensi. Metode yang digunakan dalam penelitian ini adalah metode eksperimen menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari atas 4 perlakuan dan 3 kali replikasi dengan perlakuan kontrol F0 (fermentasi menggunakan garam dapur 10%), F1 (fermentasi menggunakan garam rendah natrium 2%), F2 (fermentasi menggunakan garam rendah natrium 6%), F3 (fermentasi menggunakan garam rendah natrium 10%). Kadar natrium diuji dengan metode AAS (Atomic Absorption Spectroscopy), sedangkan uji daya terima dengan metode Hedonic Scale Scoring. Analisis data kadar natrium menggunakan one way anova dan data daya terima menggunakan analisis friedman. Hasil penelitian menunjukkan bahwa nilai rata-rata kadar natrium terendah adalah mandai pada perlakuan F1 dengan konsentrasi 2% yaitu sebesar 0,87% dengan hasil uji statistik (p=0,000<α=0,05), yang artinya ada pengaruh terhadap kadar natrium mandai goreng. Nilai tertinggi daya terima yang terdiri dari warna 3,32 (F1), aroma 3,20 (F1 dan F3), tekstur 3,12 (F1) dan rasa 3,28 (F1). Mandai rendah natrium berpengaruh terhadap daya terima rasa yang dihasilkan karena p=0,015<α(p<0,05). Rekomendasi produk mandai yang dapat dijadikan alternatif bagi penderita hipertensi adalah mandai rendah natrium dengan perlakuan F1 yaitu 0,87% yang setara dengan 870mg/100g dengan konsentrasi garam rendah natrium 2%. Kata kunci : Mandai, Kadar natrium, Daya terima mandai goreng
A Time-Domain Model of Background Noise for In-Home MIMO PLC Networks

Multiple-input multiple-output techniques have recently become an important research field for enhancing the performance of in-home power-line communication (PLC) systems by exploiting the additional protective earth wire. The development of such systems requires an accurate description of the channel noise. In this paper, we have presented a model for PLC background noise based on an extensive set of measurements. We have adopted the framework of the multivariate time series to model the PLC background noise. This paper employs the vector autoregressive modeling technique to extract noise model parameters from the measured noise. We have verified the accuracy of the noise model by comparing time- and frequency-domain correlation of measured and modeled noise.
Mobile Phone-Connected Wearable Motion Sensors to Assess Postoperative Mobilization

Background Early mobilization after surgery reduces the incidence of a wide range of complications. Wearable motion sensors measure movements over time and transmit this data wirelessly, which has the potential to monitor patient recovery and encourages patients to engage in their own rehabilitation. Objective We sought to determine the ability of off-the-shelf activity sensors to remotely monitor patient postoperative mobility. Methods Consecutive subjects were recruited under the Department of Neurosurgery at Columbia University. Patients were enrolled during physical therapy sessions. The total number of steps counted by the two blinded researchers was compared to the steps recorded on four activity sensors positioned at different body locations. Results A total of 148 motion data points were generated. The start time, end time, and duration of each walking session were accurately recorded by the devices and were remotely available for the researchers to analyze. The sensor accuracy was significantly greater when placed over the ankles than over the hips (P<.001). Our multivariate analysis showed that step length was an independent predictor of sensor accuracy. On linear regression, there was a modest positive correlation between increasing step length and increased ankle sensor accuracy (r=.640, r 2=.397) that reached statistical significance on the multivariate model (P=.03). Increased gait speed also correlated with increased ankle sensor accuracy, although less strongly (r=.444, r 2=.197). We did not note an effect of unilateral weakness on the accuracy of left- versus right-sided sensors. Accuracy was also affected by several specific measures of a patient’s level of physical assistance, for which we generated a model to mathematically adjust for systematic underestimation as well as disease severity. Conclusions We provide one of the first assessments of the accuracy and utility of widely available and wirelessly connected activity sensors in a postoperative patient population. Our results show that activity sensors are able to provide invaluable information about a patient’s mobility status and can transmit this data wirelessly, although there is a systematic underestimation bias in more debilitated patients.
Open-access endoscopy service for general practitioners.

of Otago Act of 1961 gave autonomy back to the University of Otago, which it had lost to the University of New Zealand in 1869. The MB ChB(Otago) dates from 1962. Professor Morrell describes how "the university celebrated its recovered autonomy by a degree-giving ceremony on 27 July 1962," not, as stated by Dr Hocken, in 1972.2 In the last paragraph of the first column on p 325 Dr Hocken says that "the first 120 students from the self-sufficient school at Auckland graduated in 1974. " It was on 23 November 1973 that 40 students graduated from an initial intake of 60 students.3
BODY COMPOSITION, HYDRATION, AND RELATED PARAMETERS IN HEMODIALYSIS VERSUS PERITONEAL DIALYSIS PATIENTS

♦ Aims: Maintaining euvolemia is an important goal in patients on renal replacement therapy. However, adequate assessment of volume status in clinical practice is hampered by a lack of accurate measuring tools. A new multifrequency bioimpedance tool has recently been validated. This study compares volume status in peritoneal dialysis (PD) and hemodialysis (HD) patients in a single center. ♦ Methods: Body Composition Monitoring (BCM; Fresenius Medical Care, Bad Homburg, Germany) was performed in all patients on PD or HD without contraindication. PD patients were measured with a full abdomen; HD patients were measured at the midweek session, once immediately before and once 20 minutes after dialysis. Clinical overhydration was defined as an overhydration-to-extracellular water ratio of >0.15. ♦ Results: Total body water, extracellular water, and intracellular water were 33.7 ± 6.9 L versus 31.8 ± 8.1 L vs 33.9 ± 6.7 L, 16.4 ± 3.9 L vs 15.3 ± 4.9 L vs 16.8 ± 3.3 L, and 17.1 ± 6.2 L vs 16.5 ± 4.6 L vs 17.2 ± 3.9 L in the pre-HD, post-HD, and PD patients, respectively (p = NS). In the pre-HD and the PD patients, overhydration was 1.9 ± 1.7 L and 2.1 ± 2.3 L, whereas post-HD this was only 0.6 ± 1.7 L (p < 0.001). Clinical overhydration was more prevalent in pre-HD and PD patients compared to post-HD patients (24.1% vs 22.3% vs 10%, p < 0.001). In multivariate models, overhydration was related to age, male gender, and post-HD status. ♦ Conclusion: Although much clinical attention is paid to volume status, 24% of patients still have clinically relevant volume overload. Implementation of a reliable and clinically applicable tool to assess volume status is therefore necessary. It is possible to obtain comparable volume status in PD and HD patients.
Newly diagnosed hypertension and depressive symptoms: how would you treat?

Examination • Patient is in no acute distress • Approximately 30 pounds over ideal body weight • Other vital signs are normal • Normal retinal examination, no carotid bruits, and clear lungs. Cardiac rate and rhythm are regular; no abdominal bruits • Laboratory studies reveal normal renal function; cholesterol, 184 mg/dL; low-density lipoprotein (LDL) cholesterol, 129 mg/dL; high-density lipoprotein (HDL) cholesterol, 55 mg/dL; triglycerides, 163 mg/dL. Electrocardiogram shows no current or A 56-year-old man who has had borderline hypertension for 2 to 3 years presents at a regularly scheduled office visit with blood pressure of 149/91 mm Hg.
Accuracy of occupational histories obtained from wives.

The study was conducted at two Southampton hospitals during evening visiting periods. Female patients under the age of 55 who were being visited by their husbands and who were well enough to take part were asked to complete a self administered questionnaire giving their husband's lifetime occupational history. Simultaneously, one of us interviewed the husband and requested the same information. To ensure that the histories from husbands and wives were independent, the interviews and questionnaires were completed in separate rooms as
Incidence of dementia and Alzheimer's disease in elderly community residents of south-western France.

BACKGROUND Dementia is a growing problem in developed countries. The aim of this paper is to estimate incidence rates of dementia, Alzheimer's disease and vascular dementia in a community population of South-Western France. METHODS A sample of 2792 subjects was selected and followed-up 1 year and 3 after the initial screening. At each visit, a standardized questionnaire was administered by trained psychologists. Demented subjects were identified using a two-step procedure. The first step consisted of a systematic screening by the psychologist using DSM IIIR criteria for dementia. In the second step, subjects who fulfilled the DSM IIIR criteria were examined by a neurologist. NINCDS-ADRDA criteria were applied to diagnose Alzheimer's disease. RESULTS Incidences of dementia and Alzheimer's disease were estimated at 16.3 and 11.4 per 1000 per year, respectively. Incidence estimates increased with age from 2 per 1000 in subjects aged 65-69 years to 74 per 1000 in subjects > 90 years. Incidence estimates of Alzheimer's disease showed the same increased from 0.7 per 1000 to 66 per 1000. Incidences of dementia and of Alzheimer's disease did not level off with age and were not different between genders.
2D2LPI: Two Directional Two Dimensional Locality Preserving Indexing

In this paper, a new method of representing images called two directional two dimensional locality preserving indexing called 2D 2 LPI is presented. It is an extension of the two dimensional locality preserving indexing (2DLPI) method. The authors argue that the recently proposed 2DLPI reduces the dimensions of images in row direction and we propose an alternate way of reducing the dimension in column direction. Later the authors propose a method to reduce the size of an image both in row and column directions. To corroborate the efficacy of the proposed two directional two dimensional approach the authors design a model for person identification based on single instance of finger knuckle print and subsequently the authors propose a feature level fusion of multi-instance finger knuckle print for person identification. Also to study the suitability of the proposed approach on a different domain, a study on video summarization is also presented in this paper. The results of the proposed method are compared with that of the state of the art techniques such as 2D 2 PCA, 2D 2 LPP and it is found that the proposed 2D 2 LPI model is more competitive in terms of accuracy.