Miracle-dz/UniFAR-FTUs huggingface dataset:
Transmission Performances of CPW Lines on a Laser-Crystallization Polysilicon Passivated High-Resistivity Silicon Substrate

In this paper, we report the preparation of polycrystalline silicon by excimer laser-crystallization of amorphous silicon α and its use as a surface-passivation layer (SPL) on high-resistivity silicon (HR-Si) substrates. The transmission loss (αTL) of coplanar waveguide (CPW) lines on an oxide-coated HR-Si substrate with a 100-nm excimer laser-annealed (ELA) SPL is less than 1.16 dB/cm at frequencies up to 20 GHz. Therefore, an ELA-SPL is capable of providing good surface passivation for radio-frequency integrated circuit applications. The influence of geometric parameters on the transmission characteristics of the CPW lines is also studied. Extracted material parameters and equivalent lumped elements are used to interpret the loss mechanisms.
Ultrasound Image Denoising using Multiscale Ridgelet Transform with Hard and

Ultrasound imaging utilizes sound waves reflected from different organs of the body to give local details and important diagnostic information on the human body. However, using ultrasound images for diagnosis is difficult because of the existence of speckle noise in the image. The speckle noise is due to interference between coherent waves which are backscattered by targeted surfaces and arrive out of phase at the sensor. This hampers the perception and the extraction of fine details from the image. Speckle reduction/filtering i.e. visual enhancement techniques are used for enhancing the visual quality of the images. The multscale ridgelet transform based denoising algorithm for Ultrasound images is proposed for effective edge preservation in comparison to filtering techniques using the Adaptive Filters.
Chlamydia trachomatis infection in fertile and subfertile women in Rwanda: prevalence and diagnostic significance of IgG and IgA antibodies testing.

BACKGROUND In many developing countries, little is known about the prevalence of genital Chlamydia trachomatis infections and complications, such as infertility, thus preventing any policy from being formulated regarding screening for C. trachomatis of patients at risk for infertility. The objective of the present study was to determine the prevalence of C. trachomatis and evaluate the diagnostic utility of serological markers namely anti-C. trachomatis IgG and IgA antibodies in women attending an infertility clinic. METHODS Serum and vaginal swab specimens of 303 women presenting with infertility to the infertility clinic of the Kigali University Teaching Hospital and 312 fertile controls who recently delivered were investigated. Two commercial species-specific ELISA were used to determine serum IgG and IgA antibodies to C. trachomatis and vaginal swabs specimens were tested by PCR. Hysterosalpingography (HSG) was performed in subfertile women. RESULTS The PCR prevalence of C. trachomatis infection was relatively low and did not differ significantly among subfertile and fertile women (3.3 versus 3.8%). Similarly, no significant differences in overall prevalence rates of C. trachomatis IgG and IgA among both groups were observed. The only factor associated with C. trachomatis infection in our study population was age <25 years. The seroprevalence of IgG in both assays (86.4% for ANILabsystems and 90.9% for Vircell) was significantly higher in the group of PCR C. trachomatis-positive women compared with that of PCR-negative women. Evidence of tubal pathology identified by HSG was found in 185 patients in the subfertile group (67.8%). All the serological markers measured in this study had very low sensitivities and negative predictive values in predicting tubal pathology. The specificities for ANILabsystems IgG, Vircell IgG, Anilabsystem IgA and positive C. trachomatis DNA to predict tubal pathology were 84, 86, 95 and 98%, respectively, whereas their respective positive predictive values were 73, 76, 81 and 80%. CONCLUSIONS The prevalence of C. trachomatis in our study population in Rwanda appears to be low and women aged <25 years are more likely to have genital infection with C. trachomatis. Since serological testing for Chlamydia shows an excellent negative predictive value for lower genital tract infection, specific peptide-based serological assays may be of use for screening in low prevalence settings. Our data suggest that C. trachomatis is not the primary pathogen responsible for tubal pathology in Rwandan women.
Routine aerobic terminal subculturing of blood cultures in a cancer hospital

Routine terminal aerobic subcultures of macroscopically negative blood culture bottles were evaluated during a 15-month period when 30,000 blood cultures were processed. Each blood culture set consisted of a vented and an unvented 50-ml broth bottle. Forty-eight pathogens and 47 contaminants were isolated only from terminal subcultures. Twenty-two of the significant isolates were yeasts (usually recovered from vented bottles), and 10 were Pseudomonas aeruginosa (usually recovered from unvented bottles). Blood cultures that were positive by terminal subculture provided clinically relevant information in many cases, whether other blood cultures were positive or not. Microbiology laboratories, particularly those in hospitals where yeasts and P. aeruginosa are commonly isolated from blood specimens, should evaluate carefully the need for terminal subcultures of blood culture bottles before abandoning their use.
Quality-dependent Score-level Fusion of Face, Gait, and the Height Biometrics

This paper describes a quality-dependent score-level fusion framework of face, gait, and the height biomet- rics from a single walking image sequence. Individual person authentication accuracies by face, gait, and the height biometrics, are in general degraded when spatial resolution (image size) and temporal resolution (frame-rate) of the input image sequence decrease and the degree of such accuracy degradation differs among the individual modalities. We therefore set the optimal weights of the individual modalities based on linear logistic regression framework de- pending on a pair of the spatial and temporal resolutions, which are called qualities in this paper. On the other hand, it is not a realistic solution to compute and store the optimal weights for all the possible qualities in advance, and also the optimal weights change across the qualities in a nonlinear way. We thus propose a method to estimate the optimal weights for arbitrary qualities from a limited training pairs of the optimal weights and the qualities, based on Gaussian process regression with a nonlinear kernel function. Experiments using a publicly available large population gait database with 1,935 subjects under various qualities, showed that the person authentication accuracy improved by successfully estimating the weights depending on the qualities.
Arsenic Trioxide Is a Potent Inhibitor of the Interaction of SMRT Corepressor with Its Transcription Factor Partners, Including the PML-Retinoic Acid Receptor α Oncoprotein Found in Human Acute Promyelocytic Leukemia

ABSTRACT The SMRT corepressor complex participates in transcriptional repression by a diverse array of vertebrate transcription factors. The ability to recruit SMRT appears to play a crucial role in leukemogenesis by the PML-retinoic acid receptor α (RARα) oncoprotein, an aberrant nuclear hormone receptor implicated in human acute promyelocytic leukemia (APL). Arsenite induces clinical remission of APL through a incompletely understood mechanism. We report here that arsenite is a potent inhibitor of the interaction of SMRT with its transcription factor partners, including PML-RARα. Arsenite operates, in part, through a mitogen-activated protein (MAP) kinase cascade culminating in phosphorylation of the SMRT protein, dissociation of SMRT from its nuclear receptor partners, and a relocalization of SMRT out of the nucleus into the cytoplasm of the cell. Conversely, inhibition of this MAP kinase cascade attenuates the effects of arsenite on APL cells. Our results implicate SMRT as an important biological target for the actions of arsenite in both normal and neoplastic cells.
The Effect of Tape on Glenohumeral Rotation Range of Motion in Elite Junior Tennis Players

Objective:The purpose of this study was to establish if, in elite junior tennis players, there is a difference between the dominant and nondominant shoulders in the internal and external range of motion (ROM) of the shoulder and to examine the effect of taping the dominant shoulder on glenohumeral internal and external rotation ROM. Design:Measurement of glenohumeral rotational ROM was performed on the dominant and nondominant shoulders in supine with the humerus abducted to 90 degrees. Setting:Training room at the New South Wales Institute of Sport tennis center, Homebush, New South Wales, Australia. Participants:Eleven asymptomatic male subjects and 10 asymptomatic female subjects from an elite junior training squad participated in the study. Intervention:Humeral head repositioning with tape. Main Outcome Measure:Glenohumeral ROM. Results:A statistically significant decrease in internal rotation for both the male and female groups between the dominant and nondominant shoulders, but only the female group had a significant increase in external rotation in the dominant compared with the nondominant shoulder. There was also a statistically significant increase in range between the tape and no tape conditions for each rotation condition. Conclusions:The specific application of tape to the glenohumeral joint can immediately increase rotational ROM in the dominant arm of tennis players.
NKp30‐dependent cytolysis of filovirus‐infected human dendritic cells

Understanding how protective innate immune responses are generated is crucial to defeating highly lethal emerging pathogens. Accumulating evidence suggests that potent innate immune responses are tightly linked to control of Ebola and Marburg filoviral infections. Here, we report that unlike authentic or inactivated Ebola and Marburg, filovirus‐derived virus‐like particles directly activated human natural killer (NK) cells in vitro, evidenced by pro‐inflammatory cytokine production and enhanced cytolysis of permissive target cells. Further, we observed perforin‐ and CD95L‐mediated cytolysis of filovirus‐infected human dendritic cells (DCs), primary targets of filovirus infection, by autologous NK cells. Gene expression knock‐down studies directly linked NK cell lysis of infected DCs to upregulation of the natural cytotoxicity receptor, NKp30. These results are the first to propose a role for NK cells in the clearance of infected DCs and the potential involvement of NKp30‐mediated cytolysis in control of viral infection in vivo. Further elucidation of the biology of NK cell activation, specifically natural cytotoxicity receptors like NKp30 and NKp46, promises to aid our understanding of microbial pathology.
Augmented peripheral chemosensitivity as a potential input to baroreflex impairment and autonomic imbalance in chronic heart failure.

BACKGROUND The precise mechanisms responsible for the sympathetic overactivity and blunted baroreflex control in chronic heart failure (CHF) remain obscure. Augmented peripheral chemosensitivity has recently been demonstrated in CHF. We evaluated the relation between peripheral chemoreflex sensitivity and autonomic activity in patients with CHF. METHODS AND RESULTS We studied in 26 stable patients with CHF the peripheral chemosensitivity (ventilatory response to hypoxia using transient inhalations of pure nitrogen), autonomic balance (spectral analysis of heart rate variability [HRV]), and baroreflex sensitivity (bolus phenylephrine method and alpha index). To determine whether transient inactivation of peripheral chemoreceptors might influence autonomic balance, 12 patients underwent a second study during which they breathed 100% O2. Peripheral chemosensitivity correlated inversely with HRV power within the low-frequency band (0.04 to 0.15 Hz) (r=-.52, P=.006) and inversely with baroreflex sensitivity (r=-.60, P=.005). When the patients were divided into two groups according to the chemosensitivity of age-matched normal controls (above and below mean+2 SDs of chemosensitivity of control subjects), those above the normal range revealed more impaired autonomic balance, ie, lower baroreflex sensitivity (1.4 +/- 1.3 versus 5.0 +/- 1.5 ms/mm Hg, P<.0001) and depressed values of low-frequency power (2.5 +/- 1.8 versus 4.1 +/- 0.8 ln ms2, P<.005) compared with those with normal chemosensitivity. Transient hyperoxia did not alter heart rate or systolic pressure but resulted in an increase in HRV and an improvement in baroreflex sensitivity. CONCLUSIONS A link between increased peripheral chemosensitivity and impaired autonomic control, including baroreflex inhibition, is demonstrated. The clinical importance of this phenomenon warrants further investigation.
How Men Manage Bulbar Urethral Stricture by Concealing Urinary Symptoms

In this article, we present findings from research conducted as part of a multi-center surgical trial. Bulbar urethral stricture, a narrowing of the middle urethra, is a common cause of urinary problems in men that can have a profound impact on their lives. Semi-structured interviews were conducted with a sample of 19 men seeking treatment for urethral stricture. The findings reveal how men tend to develop routines and tactics to adapt to their symptoms and hide them from others rather than seek help. We argue that this concealment becomes an inseparable part of how the disease is managed and is an additional hidden practical and emotional burden for these men. In addition, we suggest that the patients only sought curative treatments once practices of social concealment are no longer viable.
An application of Immersion and Invariance to transient stability and voltage regulation of power systems with unknown mechanical power

This paper presents the application of Immersion and Invariance (I&I) strategy to transient stability and voltage regulation of power systems with unknown mechanical power. The proposed controller is made adaptive with respect to the mechanical power by using a finite time estimator. Computing results show the effectiveness of the proposed adaptive nonlinear control strategy.
Biogenic volatile organic compound (VOC) emissions from forests in Finland

We present model estimates of biogenic volatile organic compound (VOC) emissions from the forests in Finland. The emissions were calculated for the years 1995-1997 using the measured isoprene and monoterpene emission factors of boreal tree species together with detailed satellite land cover information and meteorological data. The three-year average emission is 319 kilotonnes per annum, which is significantly higher than the estimated annual anthropogenic VOC emissions of 193 kilotonnes. The biogenic emissions of the Finnish forests are dominated by monoterpenes, which contribute approximately 45% of the annual total. The main isoprene emitter is the Norway spruce (Picea abies) due to its high foliar biomass density. Compared to the monoterpenes, however, the total isoprene emissions are very low, contributing only about 7% of the annual forest VOC emissions. The isoprene emissions are more sensitive to the meteorological conditions than the monoterpene emissions, but the progress of the thermal growing season is clearly reflected in all biogenic emission fluxes. The biogenic emission densities in northern Finland are approximately half of the emissions in the southern parts of the country.
Efficient probabilistic fault tree analysis of safety critical systems via probabilistic model checking

The cost and complexity involved in the development of critical systems encourage the use of reliability assessment techniques as early in the design cycle as possible. Existing techniques often lack the capacity to perform a comprehensive and exhaustive analysis on complex redundant architectures, leading to less than optimal risk evaluation. This paper addresses these weaknesses by 1) proposing a new probabilistic modeling of Fault Tree gates and their composition as Markov Decision Processes; 2) developing a new formal-based technique to perform an in-depth verification of the system’s reliability. This technique makes use of the expressiveness of fault trees and the power of probabilistic model checking in order to investigate the best Triple Modular Redundancy partitioning and configuration of a system. The presented approach greatly improves the overall scalability with respect to other techniques, while also improving the accuracy of the results. For example, we can provide probabilistic failure rates for a chain of 100 redundant components in little over one second.
The Sigma Factor AlgU Plays a Key Role in Formation of Robust Biofilms by Nonmucoid Pseudomonas aeruginosa

ABSTRACT The extracytoplasmic function sigma factor AlgU of Pseudomonas aeruginosa is responsible for alginate overproduction, leading to mucoidy and chronic infections of cystic fibrosis patients. We investigated here the role of AlgU in the formation of nonmucoid biofilms. The algU mutant of P. aeruginosa PAO1 (PAOU) showed a dramatic impairment in biofilm formation under dynamic conditions. PAOU was defective both in cell attachment to glass and in development of robust, shear-resistant biofilms. This was explained by an impaired production of extracellular matrix, specifically of the exopolysaccharide Psl, as revealed by microscopy and enzyme-linked immunosorbent assay. Complementing the algU mutation with a plasmid-borne algU gene restored wild-type phenotypes. Compared with that in PAO1, expression of the psl operon was reduced in the PAOU strain, and the biofilm formation ability of this strain was partially restored by inducing the transcription of the psl operon. Furthermore, expression of the lectin-encoding lecA and lecB genes was reduced in the PAOU strain. In agreement with the requirement of LecB for type IV pilus biogenesis, PAOU displayed impaired twitching motility. Collectively, these genetic downregulation events explain the biofilm formation defect of the PAOU mutant. Promoter mapping indicated that AlgU is probably not directly responsible for transcription of the psl operon and the lec genes, but AlgU is involved in the expression of the ppyR gene, whose product was reported to positively control psl expression. Expressing the ppyR gene in PAOU partially restored the formation of robust biofilms.
Vaspin Attenuates RANKL-Induced Osteoclast Formation in RAW264.7 Cells

Visceral adipose tissue-derived serine protease inhibitor (vaspin), an adipokine that was recently identified in a rat model of type 2 diabetes, has been suggested to have an insulin-sensitizing effect. In this study, we investigated whether vaspin inhibits receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis using two types of osteoclast precursors: RAW264.7 cells and bone marrow cells (BMCs). Vaspin inhibited RANKL-induced osteoclastogenesis in RAW264.7 cells and BMCs. Interestingly, vaspin also inhibited the RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1) in RAW264.7 cells and BMCs. Furthermore, it inhibited the RANKL-induced upregulation of matrix metalloproteinase-9 and cathepsin K in RAW264.7 cells. Thus, we suggest that vaspin downregulates osteoclastogenesis in part by inhibiting expression of the transcription factor NFATc1.
Tumor necrosis factor-α enhances RANKL expression in gingival epithelial cells via protein kinase A signaling.

OBJECTIVE AND BACKGROUND Periodontitis is an inflammatory disorder of the supporting tissue of teeth, which is composed of gingival soft tissue, cementum covering the tooth root, alveolar bone and periodontal ligament. The receptor activator of nuclear factor kappa B ligand (RANKL) is known to be an essential factor for osteoclastogenesis. Recent clinical studies indicate that levels of RANKL in the gingival crevicular fluid are increased while levels of its decoy receptor, osteoprotegerin (OPG), are decreased in patients with periodontitis. Although the gingival sulcus is composed of gingival tissue, RANKL and OPG expression in gingival epithelial cells is not fully understood. The aim of this study is to investigate the expression of RANKL and OPG in gingival tissue and which factors regulate RANKL expression in gingival epithelial cells. MATERIAL AND METHODS Reverse transcriptase polymerase chain reaction analysis, western blotting and immunohistochemistry were performed to confirm RANKL and OPG expression in gingival epithelial cells (GECs) and in gingival tissue. Immunostaining was also examined to confirm tumor necrosis factor (TNF)-α and TNF receptor type 1 (TNFR1) expression in gingival tissue. Ca9-22 cells, a human gingival epithelial cell line and human primary GECs were treated with TNF-α. Ca9-22 cells were treated by antibodies against TNF receptors, an inhibitor and an activator of protein kinase A (PKA) signaling and inhibitors of p38, Erk and NF-κB signaling to examine TNF-α-RANKL signaling pathways. RESULTS RANKL mRNA and protein were expressed in GECs. Immunohistochemistry also showed RANKL expression in gingival tissue. On the other hand, the reverse transcriptase polymerase chain reaction and immunohistochemistry assay showed that GECs did not express OPG. In addition, TNF-α and TNFR1 proteins were expressed in junctional epithelium. TNF-α increased RANKL expression in GECs. TNF-α-induced RANKL expression was inhibited by an antibody against TNFR1 and an inhibitor of PKA signaling. Surprisingly, forskolin, a PKA activator, increased TNF-α-induced RANKL expression. CONCLUSION RANKL, TNF and TNFR1 were coexpressed in junctional epithelium of gingival tissue. TNF-α induced RANKL expression via TNFR1 and PKA signaling in GECs of junctional epithelium.
The channel‐blocking action of methonium compounds on rat submandibular ganglion cells

1 The effects of drugs of the polymethylene bis‐trimethylammonium (methonium) series on the characteristics of the synaptic currents (e.s.cs) recorded from voltage‐clamped rat submandibular ganglion cells have been studied. The drugs studied were from C4 to C10 (decamethonium). 2 All of the drugs except C4 shortened the initial decay phase of the e.s. c. ; C9 and C10 produced an additional slowly decaying component. These effects were interpreted in terms of an open channel block mechanism, the calculated rate constants for association with the open channel at − 80 mV being fairly similar (5.9 × 106 to 18.1 × 106M−1 s−1) for all of the compounds except C4, which had no effect on the e.s. c. decay. 3 All of the compounds produced use‐dependent block when tested with short trains of stimuli at 10 Hz, or with trains of ionophoretic pulses of acetylcholine, consistent with their channel blocking property. Tubocurarine had a similar effect, but not trimetaphan or mecamylamine. 4 Recovery from use‐dependent block with short chain methonium compounds, up to C8, was very slow in the absence of agonist, being incomplete even after several minutes. With C9 or C10 or tubocurarine, recovery from use‐dependent block was complete within a few seconds. With C6 recovery in the absence of agonist was unaffected by membrane potential, but could be accelerated by applying acetylcholine with the cell depolarized to − 40 mV. This persistent block was ascribed to the ability of the blocking molecule to become trapped by closure of the channel. With C9 and C10 it is assumed that their presence inhibits channel closure, so they can escape without the help of agonist. 5 When use‐dependent block is avoided by leaving the ganglion unstimulated during equilibration with the blocking drug, the first e.s. c. elicited shows no appreciable reduction of amplitude, though with C6, C7 or C8 subsequent responses elicited at 0.1 Hz become progressively more blocked. 6 Even at 1 Mm, C6 does not prevent acetylcholine from opening ionic channels. 7 It is concluded that all of the effects on e.s. c. amplitude can be interpreted in terms of channel block, there being no evidence of any receptor blocking action.