Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluando componentes de agencia académica en la web

It is argued the need to reform structures and forms of organization at the national universities to meet the challenges of a changing world where developments in science and technology demanded that the university offer increasingly more qualified and to respond to the challenge of developing knowledge and skills for lifelong learning. In particular, where individuals show to be autonomous and responsible for be agents that intentionally make things happen, from their actions. Thus, understanding the role that play the systems of beliefs about knowledge (whether epistemological or not), much as understanding the mechanisms that use the cognitive heuristics and self-regulating responsible for university learning, constitutes a central evaluation focus and intervention in higher education, so that you can help students to exercise his personal influence in the performance of an active role in their self-development. Based on this sense of academic agency, the article offers a global perspective on it and describes the development, calibration and validation of standardized artifacts to evaluate both cognitive mechanisms (beliefs and cognitive heuristics), self-regulation (causal and motivational), insofar as they constitute core components in determining the quality of complex agentive nature learning. Finally, is the development of an evaluative tool on web that enhances the impact of the presented technological derivatives by extending the benefits of web applications to diagnosis and foster cognitive development and complex learning. In this context, further developments in learning supported by mobile technology will be cognitive artifacts responsible for promoting them.
Identity-based authenticated key exchange protocols from the Tate pairing

Key agreement protocols are designed to establish a session keys between two or multiple entities oven an insecure network and the session key is used to assure confidentiality thought encryption. With the advantages of identity-based (ID-based) cryptography, there have been many ID-based key agreement protocols proposed. However, most of them are based on Weil pairing, which is more cost of computation compared with Tate paring. In this paper, we propose a newly ID-based key agreement protocol from the Tate pairing. Compared with previous protocols, the new protocol minimizes the cost of computation with no extra message exchange time. In addition, the proposed protocol provides known key security, no key control, no key-compromise impersonation and perfect forward secrecy.
Prophylaxis of Perioperative Venous Thrombosis: Role of Venous Compression

Aim: To review the role of compression treatments in the prevention of perioperative deep venous thrombosis. Method: A review of current literature in the field of prevention of deep venous thrombosis following general and orthopaedic surgery has been conducted. Synthesis: There is a considerable risk of deep venous thrombosis following surgical treatment in hospital. This is particularly high following joint replacement in the lower limb. This may lead to fatal pulmonary embolism or chronic venous insufficiency of the lower limb with leg ulceration and disability. Perioperative deep venous thrombosis may be prevented by a number of drugs. The most frequently used is heparin or the more modern low-molecular-weight heparins (LMWH). Vitamin K antagonists are also commonly used, but have a long duration of action. Dextrans and aspirin have an effect in preventing perioperative venous thrombosis, but this is much less than heparin. Mechanical methods of prevention have the advantage of preventing venous thrombosis without increased risk of bleeding complications. Conclusion: Heparin and LMWH continue to be the most frequently used means of preventing peri-operative deep venous thrombosis in France. There is reliable to evidence to show that mechanical methods of prevention including graduated elastic compression and intermittent pneumatic compression of the lower limb are also effective. These may be used in combination with heparin for increased protection or as an alternative to anticoagulant drugs where there is a risk of bleeding. They are also effective when used alone.
Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-111).

We have recently demonstrated in a rat model that traumatic brain injury induces perturbation of cellular calcium homeostasis with an overload of cytosolic calcium and excessive calcium adsorbed on the mitochondrial membrane, consequently the mitochondrial respiratory chain-linked oxidative phosphorylation. was impaired. We report the effect of a selective N-type calcium channel blocker, SNX-111 on mitochondrial dysfunction induced by a controlled cortical impact. Intravenous administration of SNX-111 at varying times post injury was made. The concentration titration profile revealed SNX-111 at 4 mg kg -1 to be optimal, and the time window to be administration at 4 h post-injury, in line with that reported on the effect of SNX-l11 in experimental stroke. Under optimal conditions, SNX-111 significantly improved the mitochondrial respiratory chain-linked functions, such as the electron transfer activities with both succinate and NAO-linked substrates, and the accompanied energy coupling capacities measured .
Parameter optimization of robotic multidimensional force sensors

The Fisher's information matrix M is introduced for the design and calibration of robot's multidimensional force sensors. The parameter optimization is based on the standard performance index J = - lgdetM with relevant constraints. The corresponding optimality conditions should be met by the structure parameter of the force sensors in order to maximize the information content of the data. It is proved that the isotropic sensors arc maximally informative. Finally, the matching principle of the sensor's structure with its tasks is presented based on the information matrix.
Emerging classes of armed antibody therapeutics against cancer

Monoclonal antibodies represent the largest and fastest growing type of biopharmaceuticals. Their commercial and clinical success has fueled research activities aiming to improve safety and efficacy. In oncology, there is a trend towards the development of ‘armed’ antibody products, in which the immunoglobulin moiety serves for the selective in vivo pharmacodelivery of bioactive payloads such as cytotoxic drugs, bispecific antibodies, radionuclides or cytokines to sites of disease, thereby sparing healthy tissues. In this article, we review some of the most advanced preclinical and clinical activities in the field of armed antibodies and present a personal perspective on the opportunities and challenges associated with the use of this type of anti-cancer therapeutics.
Machine learning for modelling tissue distribution of drugs and the impact of transporters

The ability to predict human pharmacokinetics in early stages of drug development is of paramount importance to prevent late stage attrition as well as in managing toxicity. This thesis explores the machine learning modelling of one of the main pharmacokinetics parameters that determines the therapeutic success of a drug - volume of distribution. In order to do so, a variety of physiological phenomena with known mechanisms of impact on drug distribution were considered as input features during the modelling of volume of distribution namely, Solute Carriers-mediated uptake and ATP-binding Cassette-mediated efflux, drug-induced phospholipidosis and plasma protein binding. These were paired with molecular descriptors to provide both chemical and biological information to the building of the predictive models. Since biological data used as input is limited, prior to modelling volume of distribution, the various types of physiological descriptors were also modelled. Here, a focus was placed on harnessing the information contained in correlations within the two transporter families, which was done by using multi-label classification. The application of such approach to transporter data is very recent and its use to model Solute Carriers data, for example, is reported here for the first time. On both transporter families, there was evidence that accounting for correlations between transporters offers useful information that is not portrayed by molecular descriptors. This effort also allowed uncovering new potential links between members of the Solute Carriers family, which are not obvious from a purely physiological standpoint. The models created for the different physiological parameters were then used to predict these parameters and fill in the gaps in the available experimental data, and the resulting merging of experimental and predicted data was used to model volume of distribution. This exercise improved the accuracy of volume of distribution models, and the generated models incorporated a wide variety of the different physiological descriptors supplied along with molecular features. The use of most of these physiological descriptors in the modelling of distribution is unprecedented, which is one of the main novelty points of this thesis. Additionally, as a parallel complementary work, a new method to characterize the predictive reliability of machine learning classification model was proposed, and an in depth analysis of mispredictions, their trends and causes was carried out, using one of the transporter models as example. This is an important complement to the main body of work in this thesis, as predictive performance is necessarily tied to prediction reliability.
Territory marketing strategy: processes digitization and investment development

This article discusses the modern features of the development of territory marketing. The research examines the phenomenon of competitiveness of the territory within the interests of the subjects of the territory. The authors determine that one of the changes in the strategic development of territory marketing is the emergence of the “smart city” concept. The main element of the “smart cities” concept is intellectual systems based on information technologies and data analysis, significantly improving the quality of life of citizens and solving modern infrastructure problems. The research determines the features of the development of an attractive investment environment within the territories in order to ensure the efficiency of life and competitiveness system. The article considers the features and mechanisms of attracting investors within the marketing concept. The object of this research is to determine a system of tools to attract and improve the efficiency of use of investment flows as a tool for territory marketing, which increases the efficiency of processes and allows to stimulate subjects of the territory. Features in the technology of attracting investors in the modern world fully fit the concept of territory marketing.
Warlocks and Warpdrive: Contemporary Fantasy Entertainments With Interactive and Virtual Environments

From the Publisher: This book offers ten chapters examining contemporary fantasy entertainment forms that use virtual environments to amuse the participant. Called virtual fantasies by the author (as opposed to virtual realities), these entertainment forms are categorized into three main groupings. All include performance and imaginary environments as essential elementsparticipants are often simultaneously performers and audience. Many involve computer technology such as multimedia, digitized video, and online chatting. Part I covers imaginative fantasy entertainments, where the participants are required to use their imaginations to see the virtual environment. These include paper and pencil role-playing games (Dungeons and Dragons), live-action roleplaying games (International Fantasy Gaming Society rules), and collectible card games (Magic: The Gathering). Part II covers physical fantasy entertainments, where the participants need little imagination to see the virtual environment. These include computer games (Star Trek: Klingon), theme park rides (Disneylands Star Tours), and immersive museums (National Museum of the American Indian). Part III covers social fantasy entertainments, where participants have built communities based upon the virtual environment (Star Trek fandom, Star Wars influencing Ronald Reagans Pax Americana).
SERIES ''COMPREHENSIVE MANAGEMENT OF END-STAGE COPD'' Edited by N. Ambrosino and R. Goldstein Number 2 in this Series Complex chronic comorbidities of COPD

Chronic obstructive pulmonary disease (COPD) is defined by fixed airflow limitation associated with an abnormal pulmonary and systemic inflammatory response of the lungs to cigarette smoke. The systemic inflammation induced by smoking may also cause chronic heart failure, metabolic syndrome and other chronic diseases, which may contribute to the clinical manifestations and natural history of COPD. Thus COPD can no longer be considered a disease only of the lungs, as it is often associated with a wide variety of systemic consequences. A better understanding of the origin and consequences of systemic inflammation, and of potential therapies, will most likely lead to better care of patients with COPD. Medical textbooks and clinical guidelines still largely ignore the fact that COPD seldom occurs in isolation. As the diagnosis and assessment of severity of COPD may be greatly affected by the presence of comorbid conditions, the current authors believe that lung function measurement, noninvasive assessment of cardiovascular and metabolic functions, and circulating inflammatory markers (e.g. C-reactive protein) might help to better characterise these patients. Similarly, preventive and therapeutic interventions should address the patient in their complexity.
Applying Customer Lifetime Value to Justify Investment in Clinic Management System to Improve Customer Engagement in a Multi Chain Clinic

In Harmony Clinic is the first vaccination clinic in Indonesia. Currently, there are potential competitors readily acquire its market. The aims of this study are to explore customers’ perception, frustration points, analyze the root causes, ways to improve customer experience, investment needed and its justification. We did initial field exploration using qualitative analysis. Customers’ insights were derived from IDI and FGD. Operational processes were analyzed using visual stream mapping and any gap between what should be and what has been done were identified. Potential problems were analyzed using quantitative analysis to quantify customer complaint rate, its classification, frequency of operational defects, and its pareto chart. Fish bone diagram was used to analyze the potential root causes. We propose to provide quality personnel training & performance management, establish service procedure, and system implementation to support operation. Current clinic management system is not sufficient to support growing multichain clinics like ours anymore, hence an upgraded version is needed. We then analyze the NPV of investment needed, our WACC, our current cumulative total CLV and finally compare it with predicted future cumulative CLV produced from increasing customer engagement using sensitivity analysis to ultimately justify our investment. Keywords—Operational excellence; customer experience; customer engagement; CLV; investment analysis; WACC
Influencia de los ácidos grasos poliinsaturados omega-3 y omega-6 de la dieta y de sus metabolitos en la respuesta inmune de tipo alérgico

The prevalence rates for allergic diseases has increased markedly in the last fifty years, both in developed and developing countries, in which, such increase is mainly represented by the population of children and teens, an event which in turn is conceived as a major public health problem worldwide. Many factors have been proposed trying to explain the causes of this problematic, among which highlights the diet hypothesis, pointing that specific components of feeding and changes in the patterns of the same, would promote the development of allergies and will influence the increase from its prevalence. In support of which, the fat hypothesis, showing that parallel to the rise in allergies worldwide, also has been an excessive consumption of foods with high content of omega-6 fatty acids and low in omega-3, mainly in western diets and as result of interventions in cardiovascular risk prevention, which together could explain part of this global phenomenon, aspects will be to board in the present thematic review.
Simulación de un esquema de un esquema de fec (forward error correction) en base al estandar dvb (digital video broadcasting)

The wireless communication medium requires employing forward error correction methods on the data transferred, where Reed-Solomon & Viterbi coding techniques are generally utilized, because of performance and security reason. In this paper we present a modular design of phase encoding these codes for concatenation using System Generator of Xilinx and oriented to implementation with field programmable gate arrays (FPGA). The work begins with a review of code concept and the definition of the components and the model and the description of the behavioral. Later, the architecture is made based in model based design. The scheme of FEC will be done according to the specifications of the DVB standard for the digital Digital television. ESCUELA SUPERIOR POLITÉCNICA DEL LITORAL CENTRO DE INVESTIGACIÓN CIENTÍFICA Y TECNOLÓGICA
Maternal health care

This summary research report updates an earlier report on high-risk births and maternity care in developing countries and analyzes new data from the Demographic and Health Surveys II and III for 35 countries. The report focuses on data descriptions differences in maternal health care coverage differences over time within countries health risks in childbearing perinatal mortality and maternal health care. Maternal health is measured by prenatal care by a trained person tetanus toxoid immunization during pregnancy and delivery by a trained attendant. Findings indicate that nine countries had coverage of prenatal care of above 90% (Kenya Malawi Rwanda Tanzania Uganda Zambia Zimbabwe Kazakstan and Dominican Republic). Four countries (Niger Bangladesh Morocco and Pakistan) had levels under 35%. In 33% of the 35 countries over 25% of births were to women who received prenatal care but did not receive tetanus immunization. In most countries where women received tetanus toxoid they received two doses. Women were the least likely to have a child delivered by a trained attendant. There were greater differences in the access to delivery care than to prenatal care or immunization. In 15 countries urban women were 2.5-3 times more likely to have delivery care than rural women. Less than 33% of the 35 countries had the recommended levels (5-15%) of cesarean section deliveries. In seven countries tetanus toxoid coverage increased about 25%. In four countries prenatal care coverage increased by about 25%. In one country delivery care increased by about 25%. The improvements in coverage were associated with improved access to care for the underserved. Women who viewed themselves at risk of childbearing problems were somewhat more likely to deliver with a trained attendant. Mortality tended to be lower in countries with higher levels of service use.
Are Relative Performance Measures Useless?

Each year, hundreds of billions of dollars are moved from one investment manager to another. Frequently, these decisions are based on relative performance measurements over periods of 5 to 10 years. The authors use a Monte Carlo model to test the logic of such an approach by constructing managers that have (1) positive skill, (2) no skill, and (3) negative skill versus their benchmarks. The authors show that the typical positive-skill manager suffers a longest underperformance period (defined as the longest month-to-month period during which the returns for the simulated fund trail those of the benchmark) of approximately 10 years during 15-year simulations. Conversely, managers with negative skill enjoy longest outperformance periods of a similar length. The authors also simulate a series of very skilled managers over a 100-year period and show that, on average, there is a 25-year period in which they underperformed. These findings are confirmed by empirical analysis of the realized performance of 5,500 actively managed funds with 15-year track records from the United States, Canada, the United Kingdom, the Eurozone, Europe ex-euro, and Developed Asia ex-Japan markets. The authors conclude that the standard time frames for evaluating the relative performance of investment managers are insufficient to evaluate the skill of a manager with any degree of confidence. The authors cannot state with confidence that relative performance measures are useless, but the authors can state that they are so when they are employed in the customary fashion. TOPICS: Portfolio management/multi-asset allocation, performance measurement
Shape: Talking about Seeing and Doing

Winner, Reference Category, 2007 AAUP Book Jacket and Journal Show. In Shape, George Stiny argues that seeing shapeswith all their changeability and ambiguityis an inexhaustible source of creative ideas. Understanding shapes, he says, is a useful way to understand what is possible in design. Shapes are devices for visual expression just as symbols are devices for verbal expression. Stiny develops a unified scheme that includes both visual expression with shapes and verbal expression with signs. The relationshipsand equivalenciesbetween the two kinds of expressive devices make design comparable to other professional practices that rely more on verbal than visual expression. Design uses shapes while business, engineering, law, mathematics, and philosophy turn mainly to symbols, but the difference, says Stiny, isn't categorical. Designing is a way of thinking. Designing, Stiny argues, is calculating with shapes, calculating without equations and numbers but still according to rules. Stiny shows that the mechanical process of calculation is actually a creative process when you calculate with shapeswhen you can reason with your eyes, when you learn to see instead of count. The book takes the idea of design as calculation from mere heuristic or metaphor to a rigorous relationship in which design and calculation each inform and enhance the other. Stiny first demonstrates how seeing and counting differ when you use rulesthat is, what it means to calculate with your eyesthen shows how to calculate with shapes, providing formal details. He gives practical applications in design with specific visual examples. The book is extraordinarily visual, with many drawings throughoutdrawings punctuated with words. You have to see this book in order to read it.
A Chronic Disease Exercise Rehabilitation System Based on Cloud Computing Architecture

In view of the current status of chronic disease management development and the current society’s need for intelligent exercise monitoring, this article has conducted research on the rehabilitation system and key technologies for its realization. First, this article uses a cloud computing architecture to develop a chronic disease rehabilitation system. Secondly, based on the mobile phone system, this article has developed health-care and client terminal that can be remotely connected to the system. Finally, this article applies the personalize exercise prescription reasoning algorithm and exercise effect evaluation algorithm to the developing of the project. The system designed in this article has functions such as automatic reasoning of exercise prescriptions, remote monitoring of exercise, and evaluation of exercise effects. Tests have shown that the system operates stably and can achieve the purpose of closed-loop chronic disease management with exercise as the core. Keywords—mobile terminal; cloud computing; exercise intervention; chronic disease management