Miracle-dz/UniFAR-FTUs huggingface dataset:
What symptoms predict the diagnosis of autism or PDD-NOS in infants and toddlers with developmental delays using the Baby and Infant Screen for aUtIsm Traits

Purpose: Autism Spectrum Disorders (ASD) are characterized by life-long and severe symptoms such as stereotypies, social skills deficits and language delays. Previous research has demonstrated that children who receive early intensive behavioural intervention have a better prognosis than those who do not receive services. It is for this reason that assessments designed specifically for early identification of ASD are of paramount important. Method: In Study 1, 957 infants with autism, PDD-NOS and atypical development were evaluated using an assessment screener for ASD traits, the Baby and Infant Screen for aUtIsm Traits (BISCUIT). In Study 2, only those with an autism or PDD-NOS diagnosis were evaluated. Results: The BISCUIT was found to have an excellent overall classification rate for children in the target population. A sub-set of BISCUIT items was found that distinguished children with ASD from atypically developing children. Items were also found which could accurately predict autism vs PDD-NOS diagnosis. Conclusions: These data suggest that the core features of ASD are distinct and can be identified early in life. Furthermore, the presence of specific core behaviours can allow for a more accurate clinical and diagnostic picture for young children with autism or PDD-NOS vs general developmental delays.
Age‐associated Changes in the Immune Response

s of papers to be considered by the Program Committee for presentation at the 40th Annual Meeting should be sent to the Chairman of the Program Committee. Abstracts must be submitted in triplicate, be single spaced, be on one page only, and include: (1) Title of paper (2) Author's name and address (3) Principal hospital and/or academic appointment The text of the abstract should be a complete revealing synopsis so that the reviewers may adequately evaluate the complete work. The author should indicate at the end of the abstract, as a footnote, whether or not he or she will need a lantern-slide projector (standard size, 3% inches, or Kodachrome, 2 x 2), or a motion picture projector (size and length in minutes). Abstracts should be limited to 250 words. Each speaker will be allowed 10 to 15 minutes for the presentation of his or her paper. Moderators will enforce the 15-minute period. Speakers are urged to check the length of their presentations so that they will conform with the above requirements.s should be limited to 250 words. Each speaker will be allowed 10 to 15 minutes for the presentation of his or her paper. Moderators will enforce the 15-minute period. Speakers are urged to check the length of their presentations so that they will conform with the above requirements. ABSTRACTS MUST BE IN THE HANDS OF THE PROGRAM CHAIRMAN PRIOR TO JANUARY 10,1983, AND SHOULD BE ADDRESSED TO:S MUST BE IN THE HANDS OF THE PROGRAM CHAIRMAN PRIOR TO JANUARY 10,1983, AND SHOULD BE ADDRESSED TO: Walter M. Bortz, MD Palo Alto Medical Clinic 300 Homer Avenue Palo Alto, CA 94301 JOURNAL OF THE AMERICAN QERIATRICS SOCIETY
Effects of Insulin and LongR3 on Serum‐Free Chinese Hamster Ovary Cell Cultures Expressing Two Recombinant Proteins

Insulin is the most commonly used growth factor for sustaining cell growth and viability in serum‐free Chinese hamster ovary (CHO) cell cultures. In the present study insulin and IGF‐1 analogue (LongR3) were compared for their ability to support growth, viability, and production of two serum‐free CHO cell lines expressing recombinant protein. The first cell line, VA12, expresses protein B, and the second cell line, CL23, expresses protein C. Both molecules are recombinant cytokine receptors. VA12 will grow in serum‐free media lacking growth factor, while CL23 requires either insulin or LongR3 for cell growth. Both cell lines, however, require a growth factor for optimal performance under production conditions. In this study, LongR3 was better able to sustain the viability of both cell lines under production conditions than insulin. These data indicate that while insulin and LongR3 can both serve as growth and viability factors for CHO cells, LongR3 is the preferred growth factor for cell lines VA12 and CL23.
Novel simple harmonics compensation method for smart charger with constant DC-capacitor voltage control for electric vehicles on single-phase three-wire distribution feeders

This paper proposes a novel and simple control method for the previously proposed smart charger for electric vehicles (EVs) on single-phase three-wire distribution feeders. The proposed method consists of only the constant dc-capacitor control, which is commonly used in active power line conditioners. No detection blocks of harmonic, reactive, and unbalanced-active currents are required. Thus, we propose the simplest algorithm to compensate harmonics, reactive, and unbalanced-active currents with the proposed smart charger on single-phase three-wire distribution feeders. The basic principle of compensation characteristics for harmonic currents is discussed in detail. A computer simulation is implemented to confirm the compensation characteristics for harmonic currents using PSIM software. Simulation results demonstrate that balanced and sinusoidal source currents with a unity power factor are obtained on the secondary side of the pole-mounted distribution transformer during both the battery charging and discharging operations in EVs, compensating harmonic, fundamental reactive, and unbalanced active currents.
Physiological and Pharmacological Responses of Arterial Graft Flow After Coronary Artery Bypass Grafting Measured With an Implantable Ultrasonic Doppler Miniprobe

BackgroundThe present study was designed to investigate physiological and pharmacological responses of the arterial graft flow measured by the directly implanted ultrasonic pulsed Doppler miniprobe after coronary artery bypass grafting (CABG). Methods and ResultsOur original S-MHz, 5-mm-diameter, Doppler mini-flow probe catheter, which has four silicone brims in front to facilitate its fixation onto the graft without direct suture, was attached onto internal thoracic artery (ITA) and gastroepiploic artery (GEA) grafts during CABG in 10 patients. Approximately 2 weeks postoperatively, when the patient's condition was quite stable without medication, changes of flow velocity in those grafts induced by catecholamine, exercise, taking meals, and coronary vasodilating drugs were measured. Dobutamine significantly increased both ITA and GEA graft flow velocity (p<0.01), whereas dopamine had no distinct positive effect. Upon the patient taking meals, the GEA graft showed an 83% increase of the flow velocity (p<0.05), whereas the ITA graft showed no significant change. Walking exercise for 6 minutes increased both grafts' flow velocity up to two times that of control values (p<0.01). Oral intake of coronary vasodilating drugs showed no significant effect. After the investigation was completed, the probe was removed easily at bedside without difficulty. ConclusionsUsing this implantable Doppler miniprobe, postoperative function in the individual coronary bypass graft under various conditions was effectively investigated.
Dietary Approaches to Stop Hypertension (DASH) diet: applicability and acceptability to a UK population.

BACKGROUND The Dietary Approaches to Stop Hypertension (DASH) diet is widely promoted in the USA for the prevention and treatment of high blood pressure. It is high in fruit and vegetables, low-fat dairy and wholegrain foods and low in saturated fat and refined sugar. To our knowledge, the use of this dietary pattern has not been assessed in a free-living UK population. METHODS The DASH diet was adapted to fit UK food preferences and portion sizes. Fourteen healthy subjects followed the adapted DASH diet for 30 days in which they self-selected all food and beverages. Dietary intake was assessed by 5-day food diaries completed before and towards the end of the study. Blood pressure was measured at the beginning and end of the study to assess compliance to the DASH style diet. RESULTS The DASH diet was easily adapted to fit with UK food preferences. Furthermore, it was well tolerated and accepted by subjects. When on the DASH style diet, subjects reported consuming significantly (P < 0.01) more carbohydrate and protein and less total fat (5%, 6% and 9% total energy, respectively). Sodium intakes decreased by 860 mg day(-1) (P < 0.001). Systolic and diastolic blood pressure decreased significantly (P < 0.05) by 4.6 and 3.9 mmHg, respectively when on the DASH style diet. CONCLUSIONS The DASH style diet was well accepted and was associated with a decrease in blood pressure in normotensive individuals and should be considered when giving dietary advice to people with elevated blood pressure in the UK.
Effect of swimming velocity on arm coordination in the front crawl: a dynamic analysis

We examined the preferred mode of arm coordination in 14 elite male front-crawl swimmers. Each swimmer performed eight successive swim trials in which target velocity increased from the swimmer's usual 3000-m velocity to his maximal velocity. Actual swim velocity, stroke rate, stroke length and the different arm stroke phases were then calculated from video analysis. Arm coordination was quantified by an index of coordination based on the lag time between the propulsive phases of each arm. The index expressed the three coordination modes in the front crawl: opposition, catch-up and superposition. First, in line with the dynamic approach to movement coordination, the index of coordination could be considered as an order parameter that qualitatively captured arm coordination. Second, two coordination modes were observed: a catch-up pattern (index of coordination = −8.43%) consisting of a lag time between the propulsive phases of each arm, and a relative opposition pattern (index of coordination = 0.89%) in which the propulsive phase of one arm ended when the propulsive phase of the other arm began. An abrupt change in the coordination pattern occurred at the critical velocity of 1.8 m · s−1, which corresponded to the 100-m pace: the swimmers switched from catch-up to relative opposition. This change in coordination resulted in a reorganization of the arm phases: the duration of the entry and catch phase decreased, while the duration of the pull and push phases increased in relation to the whole stroke. Third, these changes were coupled to increased stroke rate and decreased stroke length, indicating that stroke rate, stroke length, the stroke rate/stroke length ratio, as well as velocity, could be considered as control parameters. The control parameters can be manipulated to facilitate the emergence of specific coordination modes, which is highly relevant to training and learning. By adjusting the control and order parameters within the context of a specific race distance, both coach and swimmer will be able to detect the best adapted pattern for a given race pace and follow how arm coordination changes over the course of training.
Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial.

OBJECTIVE To assess the safety and tolerability of atacicept in patients with systemic lupus erythematosus (SLE) and the biologic effect of atacicept on B lymphocyte and immunoglobulin levels. Atacicept is a TACI-Ig fusion protein that inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. METHODS This phase Ib, double-blind, placebo-controlled, dose-escalating trial comprised 6 cohorts of patients treated with atacicept or placebo in a 3:1 ratio of active drug to placebo (n = 8 per group; n = 7 in cohort 5). Cohorts 1-4 received a single subcutaneous dose of placebo or either 0.3 mg/kg, 1 mg/kg, 3 mg/kg, or 9 mg/kg of atacicept. Cohorts 5 and 6 received weekly doses of placebo or either 1 mg/kg or 3 mg/kg of atacicept for 4 weeks. Patients were followed up for 6 weeks (cohorts 1-4) or 9 weeks (cohorts 5 and 6). Patients with mild-to-moderate SLE were enrolled. RESULTS Biologic activity of atacicept was demonstrated by dose-dependent reductions in immunoglobulin levels and in mature and total B cell numbers. This effect was most pronounced in the repeated-dose cohorts and was sustained throughout the followup period. There were no changes in the numbers of T cells, natural killer cells, or monocytes. Mild injection-site reactions occurred more frequently among the atacicept group than the placebo group. There were no differences in the frequency or type of adverse events and no severe or serious adverse events in patients treated with atacicept. CONCLUSION Atacicept administered subcutaneously was well tolerated and demonstrated biologic activity consistent with the proposed mechanism of action.
Reboxetine Versus Fluvoxamine in the Treatment of Motor Vehicle Accident-related Posttraumatic Stress Disorder: A Double-blind, Fixed-dosage, Controlled Trial

Background: Motor vehicle accidents (MVAs) are a leading cause of posttraumatic stress disorder (PTSD) in the general population. Alterations in norepinephrine and serotonin systems have been proposed as mechanisms involved in the pathophysiology of the condition, with treatment directed at these neurotransmitter systems. Reboxetine, a selective norepinephrine reuptake inhibitor, exhibits high affinity and selectivity for the human norepinephrine transporter. Inasmuch as PTSD may be associated with dysregulation of noradrenergic activity, the present double-blind randomized clinical trial intended to evaluate reboxetine's efficacy in the management of MVA-related PTSD and to compare its efficacy with a medication commonly used in PTSD, the selective serotonin reuptake inhibitor fluvoxamine. Methods: Forty patients with MVA-related PTSD attending a local community mental health outpatient clinic were randomized to receive a fixed dose of either reboxetine (8 mg/d) or fluvoxamine (150 mg/d) in a double-blind fashion for a period of 8 weeks. Results: At baseline and at study end point, the 2 subgroups demonstrated no statistical differences in scores on PTSD, depression, and anxiety rating scales. Both medications led to significant improvements in all clinical scales measured. Nine patients receiving reboxetine and 3 receiving fluvoxamine withdrew from the study because of side effects. Conclusions: Study observations indicate comparable efficacy of reboxetine and fluvoxamine in the management of MVA-related PTSD despite reboxetine's selective noradrenergic activity. Reboxetine appears to be at least as effective as fluvoxamine and may offer an alternative management option in this often difficult-to-treat and disabling condition. A lower and flexible reboxetine dosing schedule will be recommended for future research to improve its tolerability in PTSD patients.
Risk of prion disease transmission from ocular donor tissue transplantation.

PURPOSE Recent new reports of possible iatrogenic transmission of Creutzfeldt-Jakob disease (CJD) in Europe have prompted renewed scrutiny of current Eye Bank Association of America criteria for evaluation of potential corneal donors in this country. A prior study evaluated the risk of CJD occurring in U.S. corneal donors by using data to 1994. This report updates these data, analyses the risk by using data to 1997, and predicts potential risk into the next decade. METHODS EBAA data inclusive through 1997 were reviewed and correlated with incidence figures for CJD in the United States as provided by the Communicable Disease Center in Atlanta. RESULTS The annual incidence of CJD has remained stable at 1 case per million population. Thus approximately 270 new cases of CJD would be expected to occur each year in the United States. From this, the calculated risk of a prion-infected corneal donor appearing in the donor pool is 0.045 cases per year. If the data are corrected for age (90% of CJD patients are older than 60 years) and for possible infected but asymptomatic CJD patients (prevalence, 70 cases per million), at worst, 2.12 cases per year would appear for potential corneal donation (0.005% of all donors). Whereas donors completely without any neurologic symptoms cannot be screened by using any currently available laboratory method, those with a characteristic quadrate clinical prodrome including cognitive changes, speech abnormalities, cerebellar findings, and myoclonus could all be potentially excluded by using tightened medical record and historical screening criteria. Although no cases of bovine spongiform encephalopathy (mad-cow disease) or new variant CJD have been reported in the United States, if such should occur, only 4.2 cases of CJD would be expected in potential donors each year (0.009% of all donors). Tightening of exclusionary queries would significantly reduce the risk of even this number of patients appearing for corneal donation. CONCLUSIONS Historical queries of potential corneal donors should be tightened to assure exclusion of donors with early neurologic alterations. Any patient undergoing autopsy for evaluation of possible central nervous system (CNS) disease should be absolutely excluded. With this approach, the risk of inclusion of CJD-infected transplant tissues derived from ocular sources is very small, and all previously reported cases would have been prospectively excluded from surgical use. Clearly, the benefits of corneal transplantation in the overall population continue significantly to outweigh the risks of transmission of prion disease.
Effects of Partial-body Cryotherapy (− 110°C) on Muscle Recovery between High-intensity Exercise Bouts

Abstract The aim of this study was to evaluate the effects of a single partial-body cryotherapy bout between training sessions on strength recovery. 12 young men (23.9±5.9 years) were randomly exposed to 2 different conditions separated by 7 days: 1) Partial-body cryotherapy (subjects were exposed to 3 min of partial-body cryotherapy at − 110 °C between 2 high-intensity training sessions); 2) Control (subjects were not exposed to partial-body cryotherapy between 2 high-intensity training sessions). Subjects were exposed to partial-body cryotherapy after the first training session. The 2 knee extension high-intensity training sessions were separated by a 40-min rest interval. Knee extension training consisted of 6 sets of 10 repetitions at 60°. s−1 for concentric actions and 6 sets of 10 at 180.s−1 for eccentric actions. The decrease in eccentric peak torque and total work was significantly (p<0.05) less after partial-body cryotherapy (5.6 and 2%, respectively) when compared to control (16 and 11.6%, respectively). However, the decrease in concentric peak torque and total work was not different (p>0.05) between partial-body cryotherapy (9.4 and 6.5%, respectively) and control (7.5 and 5.2%, respectively). These results indicate that the use of partial-body cryotherapy between-training sessions can enhance eccentric muscle performance recovery.
De Novo Synthesis of Sphingolipids Is Required for Cell Survival by Down-Regulating c-Jun N-Terminal Kinase inDrosophila Imaginal Discs

ABSTRACT Mitogen-activated protein kinase (MAPK) is a conserved eukaryotic signaling factor that mediates various signals, cumulating in the activation of transcription factors. Extracellular signal-regulated kinase (ERK), a MAPK, is activated through phosphorylation by the kinase MAPK/ERK kinase (MEK). To elucidate the extent of the involvement of ERK in various aspects of animal development, we searched for a Drosophila mutant which responds to elevated MEK activity and herein identified a lace mutant. Mutants with mild lace alleles grow to become adults with multiple aberrant morphologies in the appendages, compound eye, and bristles. These aberrations were suppressed by elevated MEK activity. Structural and transgenic analyses of the lace cDNA have revealed that the lace gene product is a membrane protein similar to the yeast protein LCB2, a subunit of serine palmitoyltransferase (SPT), which catalyzes the first step of sphingolipid biosynthesis. In fact, SPT activity in the fly expressing epitope-tagged Lace was absorbed by epitope-specific antibody. The number of dead cells in various imaginal discs of a lace hypomorph was considerably increased, thereby ectopically activating c-Jun N-terminal kinase (JNK), another MAPK. These results account for the adult phenotypes of thelace mutant and suppression of the phenotypes by elevated MEK activity: we hypothesize that mutation of lace causes decreased de novo synthesis of sphingolipid metabolites, some of which are signaling molecules, and one or more of these changes activates JNK to elicit apoptosis. The ERK pathway may be antagonistic to the JNK pathway in the control of cell survival.
Efficacy of anthracycline/taxane‐based neo‐adjuvant chemotherapy on triple‐negative breast cancer in BRCA1/BRCA2 mutation carriers

This study aims to estimate the pathologic complete response (pCR) rate after neo‐adjuvant chemotherapy and to compare disease‐free survival (DFS) and overall survival (OS) between pCR and non‐pCR groups of patients with triple‐negative breast cancer (TNBC) and deleterious BRCA1 or BRCA2 mutation. We carried out a retrospective analysis of 53 patients including 46 BRCA1, 6 BRCA2, and 1 combined BRCA1 and BRCA2 mutation. All patients had been diagnosed with triple‐negative breast cancer (TNBC) between 1997 and 2014. Neo‐adjuvant therapy consisted of regimens that were based on anthracycline or an anthracycline‐taxane doublet. DFS included any relapse or second cancer. The Kaplan‐Meier method and the log‐rank test were used to compare pCR and non‐pCR groups. A pCR was observed in 23 (42.6% [95% CI, 29.2%‐56.8%]) of the TNBC included. The pCR rate was 38.3% [95% CI, 26%‐55%] among BRCA1 mutation carriers, and 66% among the 6 BRCA2 mutation carriers. Median follow‐up was 4.4 years (range 0.62‐16.2 years) and did not differ between the groups (P = .25). Fifteen relapses and six second cancers were recorded during the follow‐up period. Eleven deaths occurred, all of which were in the non‐pCR group. DFS (P < .01) and OS (P < .01) were significantly better in the pCR group than the non‐pCR group. This study shows a high pCR rate after neo‐adjuvant therapy in BRCA‐mutated triple‐negative breast cancer, and the survival results confirm the prognostic value of pCR in this group. These outcomes should be considered as a basis of comparison to be used by future studies about new therapies in this domain.