Miracle-dz/UniFAR-FTUs huggingface dataset:
Antioxidant and Anticancer effects of curcumin - A Review Zerdeçalin Antioksidan ve Antikanser Etkileri - Derleme

Plants are nature’s remedies & have been used on earth for food and medicine since ancient times. The use of plants and their active principles in the prevention and treatment of chronic diseases is on the experience of traditional system of medicine from different ethnic societies but use in modern medicines is limited by the lack of scientific data. Few medicinal plants have attracted the interest & been the subject of scientific investigations,One plant that has been investigated is turmeric. Turmeric and its active ingredient “curcumin’’are being studied upon as chemopreventive agents in various diseases.Curcumin has a long history of use in ayurvedic medicine as a treatment for inflammatory conditions.The medicinal properties of curcumin and its analogs have been known to mankind for ages.Modern science has now provided a scientific basis to the numerous reports of the medicinal effects of these most inexpensive,yet pharmacologically safe, having numerous pharmacological activities, including antioxidant and antimicrobial properties.This review article focuses on curcumin’s anti-inflammatory,antioxidant and anticancer properties and its role in premalignat conditions of oral cavity.
Myeloperoxidase: its structure and expression during myeloid differentiation.

Myeloperoxidase (MPO) is a major protein present in myeloid cells and is used by these cells to help kill microbes. The human promyelocytic HL-60 line can be induced to differentiate to granulocytes or macrophagelike cells. Poly (A) containing RNA was isolated from HL-60 granulocytes, HL-60 macrophages, HL-60 blasts, and normal human granulocytes. The mRNA was translated in a reticulocyte lysate system in the presence of 35S-methionine. The MPO was precipitated from the lysate with rabbit IgG antiserum to human MPO. The resulting precipitate from HL-60 blasts gave a major band of radioactivity of approximately 77,000 daltons and another band at approximately 46,000 daltons on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The MPO identity of the labeled bands was confirmed by cold competition. The relative mRNA activity expressed as a percentage of radioactivity incorporated into MPO (77,000-dalton band) as compared with total trichloracetic acid (TCA) precipitable radioactivity was 0.2%. Negligible mRNA activity for MPO was present in HL-60 granulocytes, HL-60 macrophages, and normal human granulocytes. Pulse-chase experiments showed that MPO was an approximate 75,000-dalton major band and 77,000-dalton minor band of radioactivity after HL-60 blasts were labeled for 1/2 hour with 35S-methionine and the cell lysate immunoprecipitated and subjected to SDS-PAGE. The chase experiments (one to 24 hours) showed that the 77,000- and 75,000-dalton bands of radioactivity were replaced with two major bands (55,000 and 15,000 daltons) and one minor band (approximately 39,000 daltons) of radioactivity. Six-hour 35S-methionine labeling experiments showed that the relative rate of MPO synthesis compared with total TCA precipitable radioactivity was 0.5% in HL-60 blasts and almost negligible in HL-60 macrophages and granulocytes, normal human granulocytes, and B-lymphocytes. The KG-1 myeloblasts and KG-1a early myeloblasts synthesized a small amount of the 75,000-dalton MPO protein. Although HL-60 cells no longer synthesized MPO after differentiation, HL-60 granulocytes and HL-60 macrophages continued to contain MPO as measured by enzyme activity. (ABSTRACT TRUNCATED AT 400 WORDS)
Survey on the attitudes of the older American baby boomers towards institutionalized care services

Background: Currently the American society is an aging one. With the rapid increase in the number of American baby boomers expected within the next 18 years, the older population will reach 20.3% in 2050. The needs of institutionalized care facilities to accommodate these older baby boomers will significantly increase. Methods: A face‐to‐face survey interview was done at the end of 2013 to American older baby boomers aged 55 years and older in order to study their attitudes towards long‐term care services. The data indicate that more baby boomers are willing to use long‐term care services but worry about financial difficulties. Results: The results of the survey also show the respondents' concerns of the quality of nursing home services and relevant social policies about the institutionalized care system. Conclusions: Based on the survey results, we discuss the improvements of institutionalized care services and the establishments of different social policies corresponding to the baby boomers' generations.
Special Physical Education

New Tenth Edition Just Released! The Field of Special Physical Education is Evolving.As research and programs are developed, new ideas, information, and trends are discovered. The new tenth edition of Special Physical Education presents the best practices evident in the field today. To help the reader apply the new research and concepts learned, the authors have incorporated case students in each chapter. These case studies are designed to bring up the many potent points to be considered when designing and implementing a special physical education program. Now available in a new 10th edition, Special Physical Education: The latest assessment information for each disability area. Case studies for each disability areas DSM-5 2013 information for all appropriate disability areas. A separate chapter on Autism Spectrum Disorder (ASD). A new chapter entitled Intellectual Disability. An expanded chapter on nutrition and physical activity for children under or overweight.
Clofarabine and Adult Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clonal, malignant disease of hematopoietic tissues that is characterized by accumulation of abnormal blast cells, principally in the marrow and impaired production of normal blood cells. The unsatisfactory clinical outcomes of AML patients urged the development of new therapy strategies, one of which includes the implementation of new nucleoside analogs. Clofarabine has offered new promising perspectives within induction and consolidation therapies. This chapter will evaluate the efficacy and tolerability of clofarabine as a single agent and in combination therapy, in‐ cluding hematopoietic stem cell transplantation, for AML patients.
LBA15A PHASE 1B STUDY OF PEMBROLIZUMAB (PEMBRO; MK-3475) IN PATIENTS (PTS) WITH ADVANCED GASTRIC CANCER

ABSTRACT Aim: The PD-1 receptor-ligand pathway can be used by tumors to evade immune surveillance, thereby allowing neoplastic growth. Pembro is a highly selective, humanized IgG4/kappa isotype monoclonal antibody designed to block PD-1 interaction with its ligands PD-L1 and PD-L2, thus reactivating the immune system to eradicate the host tumor. In a phase 1b study (Clinicaltrials.gov: NCT01848834), we assessed the safety, tolerability, and antitumor activity of pembro in gastric cancer pts. Methods: Using a prototype immunohistochemistry assay, PD-L1 expression was assessed in archival tumor samples from pts with recurrent/metastatic adenocarcinoma of the stomach or gastroesophageal junction. Eligible pts with PD-L1 staining in stroma or ≥1% of tumor cells were enrolled and treated with pembro 10 mg/kg every 2 weeks for up to 24 months or until complete response, disease progression, or unacceptable toxicity. Enrollment was designed to include an equal number of pts from Asia Pacific (AP) and the rest of the world (ROW). Adverse events (AEs) were monitored and graded per the NCI CTCAE v4.0. Radiographic imaging was performed every 8 weeks. Primary efficacy end point was overall response rate (ORR) assessed by RECIST v1.1. Results: Of the 162 pts screened, 65 (40%) were PD-L1+ and 39 enrolled: 19 from AP, 20 from ROW. Median age was 63 y, and 72% of pts were men. Pts from AP were more heavily pretreated than pts from ROW (≥2 prior therapies in 79% vs 55%). Median follow-up duration was ∼6 mo. The most common AEs deemed treatment related by investigators were hypothyroidism and fatigue (n = 5 each). Grade ≥3 AEs deemed treatment related occurred in 3 pts (n = 1 each for hypoxia, peripheral neuropathy, and pneumonitis). ORR (confirmed + unconfirmed) was 32% in AP and 30% in ROW. Responses were ongoing for 6/6 AP pts and 5/6 ROW pts (median response duration not reached; range 8+ to 20+ wk). Evidence of an association between PD-L1 expression and PFS (P = 0.032) and ORR (P = 0.071) was observed. Conclusions: Pembro was generally well tolerated by and provided antitumor activity in pts with advanced gastric cancer that expressed PD-L1. The robust antitumor activity observed supports the further development of pembro in advanced gastric cancer. Disclosure: E.J. Gonzalez: Is employee of and holds stock in Merck & Co., Inc.; J. Pulini: Is former employee of Merck & Co., Inc.; A.B. Ray, M. Dolled-Filhart, K. Emancipator, K. Pathiraja, X. Shu and M.R. Koshiji: Is an employee of Merck & Co., Inc.; J. Cheng: Is an employee of and holds stock in Merck & Co., Inc. All other authors have declared no conflicts of interest.
Molecular epidemiological study of protozoan and other zoonotic diseases from two countries in Africa

19 Introduction.20 Materials and Methods.22 Results.25 Discussion.27 CHAPTER 2 Genetic diversity among Trypanosoma (Duttonella) vivax strains from Zambia and Ghana, based on Cathepsin L-like gene.34 Abstract.35 Introduction.36 Materials and Methods.38 Results.40 Discussion.41. 35 Introduction.36 Materials and Methods.38 Results.40 Discussion.41 CHAPTER 3 Detection and characterization of zoonotic pathogens of free-ranging non-human primates from Zambia.44
Effects of Muscular Fatigue on Knee Proprioception during Performance and Recovery of the Knee Flexors in Female Physical Education Students

هدفت هذه الدراسة إلى تعرف أثر التعب العضلي على الركبة بين القدم المهيمنة وغير المهيمنة لدى طالبات التربية الرياضية. شارك في الدراسة ستة عشر لاعبة من كلية علوم الرياضة/ جامعة مؤتة من المسجلات للفصل الدراسي الأول في كرة السلة (2) 2011/2010م. القدمان استعملتا في هذه الدراسة، القدم اليمنى (المهيمنة) استعملت كتجريبية واليسرى غير المهيمنة كضابطة. المدركات الحسية قيست بواسطة الممتحن (الطريقة السلبية) والايجابية (اللاعب) ومقدرة الطالبات على أعادة أنتاج زاوية المفصل الركبة التي عينت بواسطة الممتحن، استخدم الباحث مقياس الزوايا (goniometer) كأداة للقياس و(three factor ANOVAs) لاحتساب المتوسطات الحسابية والانحراف المعياري. خلصت الدراسة إلى عدم وجود فروق معنوية ذات دلالة إحصائية ما بين القدم اليمنى (المهيمنة) التجريبية واليسرى غير المهيمنة كضابطة فبل تدخل التعب العضلي عند مستوى α (0.05). كذلك توصلت الدراسة إلى عدم وجود فروق معنوية ذات دلاله احصائيه لتأثير التعب العضلي على المدركات الحسية في مفصل الركبة بين القدم المهيمنة وغير المهيمنة. في النتيجة خلصت الدراسة إلى عدم وجود تأثير للتعب العضلي على المدركات الحسية في مفصل الركبة بين القدم المهيمنة وغير المهيمنة. في كل الأحوال كثير من تفاصيل المدركات الحسية ليست معروفة ومعروف إن المدركات الحسية في مفصل الركبة مهمة في جميع النشاطات الرياضية، وان إصابة المدركات الحسية توثر في إلاصابات واعادة الإصابة في هذا المفصل. كذلك خلصت الدراسة إلى وجود فروق معنوية ذات دلاله احصائيه ما بين القدم اليمنى (المهيمنة) كتجريبه واليسرى وغير المهيمنة كضابطه بعد أعاده الاستشفاء. ولهذا مزيد من الأبحاث عن تأثير التعب العضلي على المدركات الحسية في مفصل الركبة ما بين الطالبات اللاعبات.
Tumores del estroma gastrointestinal. Serie de casos del Hospital Central Militar, México

Introduction. Gastrointestinal stromal tumors (GIST for short) are the most common in the gastrointestinal tract. The classification of GIST was made in 1983. Since Introduction. Gastrointestinal stromal tumors (GIST for short) are the Most common in the gastrointestinal tract. The classification of GIST was made in 1983. Zoomed Since then the Increased Prevalence With the use of immunohistochemistry. The biological behavior is based on morphological and histological Characteristics. Material and methods. A systematic retrospective study on the Pathology of the Central Military Hospital from 2000 to 2012 was Carried out we describe our experience over a period of twelve years in two stages. One in the reclassification of this neoplasm and one after it, With the description of the clinical picture, diagnosis, treatment and follow-up. Results. A Total of 33 cases Were taken in the period of 20002012. Immunohistochemical positivity was 50% diffuse cytoplasmic staining with intense. Surgical treatment was performed in the HCM and six other hospitals. Discussion. Treatment is complete resection with wide margins. Since it was possible to standardize the systemic treatment based on molecular target therapy. The experience in Mexico is limited and is Described in some series.
Factors affecting the outcome of IVF/ICSI

Fertility declines with advancing age and the number of couples seeking infertility treatment at an older age is constantly increasing. A top quality embryo is believed to have the highest potential for implantation and development into a child. A better understanding of the relative importance of patient and treatment characteristics and of embryo quality could help to optimise the existing therapeutic schemes and the safety of in vitro fertilisation/intracytoplasmic sperm injection (IVF/ ICSI). In this work, databases of five Finnish infertility clinics were studied retrospectively. Data on treatments performed in the years 1994–2005 were collected. A total of 19,000 treatment cycles were analysed. Special attention was paid to the relative significance of the transfer of top quality embryos with regards to pregnancy, miscarriage, live birth and cost of treatment in the general IVF/ICSI patient population and in groups with expected poor outcome. The results showed that the transfer of a top quality embryo is associated with a better chance of pregnancy and live birth. However, it does not diminish the probability of miscarriage. Both low and high BMI increase the miscarriage rate. Advancing age and a positive history of previous miscarriages are also associated with a higher probability of miscarriage. In addition, the need for hormonal substitution in cases of frozen-embryo transfer is a risk factor of miscarriage, probably because of suboptimal endometrial function. Since the transfer of several embryos leads to multiple pregnancies, which are associated with a high risk of maternal and fetal complications, elective single embryo transfer (eSET) of a top quality embryo allows all additional good quality embryos to be frozen and transferred later in frozen-thawed embryo transfer cycles. The present work demonstrates that eSET is a safe treatment strategy at least until the age of 40. However, it might not be performed in women with fewer than four collected oocytes, since the prognosis might remain poor even if the response is improved in a following cycle. When eSET is applied routinely and on a large scale, it diminishes treatment costs while increasing the number of deliveries occurring at term, making IVF/ICSI at the same time safer and more affordable even to patients without access to reimbursed IVF treatment.
Effect of inclusion of L-carnitine fumarate on dry matter intake in Holstein cows during the period of transition to lactation

L-carnitine participates in the transport of fatty acids through the mitochondrial membrane; this facilitate the β-oxidation of fatty acids for the energy producction in the liver. L- carnitine could promote the lipid metabolism during the transition period getting a better energy status in the cows. Purpose of this study was to evaluate the effect of the inclusion of L-carnitine fumarate on the dry matter intake (DMI) in Holstein cows during that period. 21 Holstein cows between second and sixth calving and finishing the last gestation third, were assigned to three treatments with different levels of inclusion of fumarate of L-carnitine: (0.0, 100.0 y 200.0 g/cow/d). Forage, food supplement and faeces samples were collected to estimate DMI of the forage (DMIf), of the supplement (DMIs) and total (DMIt). Data were evaluated through a completely at random statistical design of repeated measures in the time using the PROC MIXED SAS 8.0. Significatively statistical changes were found for DMIfp<0.06, DMIs p<0.001 and DMIt p<0.05 in relation to sample days, but not in relation to the inclusion levels of L-carnitine of fumarate.
Komplementärmedizin in der Onkologie - eine Einführung

Komplementäre Krebstherapien werden als ergänzende Methoden in der Onkologie angewendet. Im Gegensatz zu alternativen Therapien, welche anstelle (alternativ) konventioneller Verfahren empfohlen werden. Die Richtung, welche etablierte, komplementäre Methoden in die Onkologie integrieren möchte, wird «integrative Onkologie» genannt. In der Schweiz benutzen etwa 40% der Patienten alternative oder komplementäre Verfahren bei Krebs. Unzufriedenheit mit der Schulmedizin ist kein prädiktiver Faktor für den Gebrauch von Komplementäroder Alternativmedizin. 50% der Ärzte verordnen alternative oder komplementäre Therapien bei Krebs. Davon machen es 67% auf Wunsch des Patienten, 47% glauben, dass Komplementärmedizin ihrem Patienten helfen könnte. In der Schweiz sind fünf komplementäre Therapien (Anthroposophische Medizin, Homöopathie, Neuraltherapie, Phytotherapie, Traditionelle Chinesische Medizin) in den Leistungskatalog der Krankenversicherungen provisorisch bis 2005 aufgenommen. Eine Studie im US-Staat Washington, wo Komplementärund Alternativmedizin von der Versicherung bezahlt wird, zeigt, dass die Ausgaben für Komplementärund Alternativmedizin bei Krebspatienten unter der 2%-Grenze liegen. Bedenkliche Methoden bei Krebs sowie Nutzen, Interaktionen und Nebenwirkungen von komplementären Therapien müssen dem Arzt, welcher sich mit dem Patienten über unkonventionelle Verfahren unterhalten können sollte, bekannt sein. Gute Forschung in der Komplementärmedizin bei Krebs bedingt neben finanziellen Mitteln, eine offene, interdisziplinäre Zusammenarbeit zwischen Komplementärmedizinern, Onkologen und Forschern mit einer soliden Studienerfahrung.
Pain Management in Triage and Reducing Percentage of Left without Being Seen in an Overcrowded ED

Although in most emergency rooms, the patient is seen first by a highly trained triage nurse, the ED physician is trained to determine if the patient can safely leave the ED prior to in-depth exam, treatment and diagnosis. The goal is to keep the left without being seen by a physician percentage low, since a high number would indicate poor quality, additionally patients who present with pain, and then leave the ED prior to being seen can pose a greater risk. This study examined the association of nurse-initiated triage pain protocol on the LWOBS percentage rate of patients who present with a chief complaint of pain in an urban ED located in Southern California, and to identify whether LWOBS can be predicted from the knowledge of an individual's risk factors (age, gender, race/ethnicity), pain severity, pain protocol, and wait time. A test of the full model against a constant only model was statistically significant. Hosmer-Lemeshow test indicated the model was a good fit to the data, and prediction success overall was 86.2%. The most important patient characteristics associated with disposition were treatment in triage and treatment order entry by provider. Treatment in triage was significantly associated with being seen by a physician. These significant findings reflect 94.2% patients who stayed to be seen by the provider were treated in triage for pain. Treatment by provider order entry was highly significant. Results indicate that there is an association between the treatment order entered by provider and if they stayed to be seen. The findings reflected that 71.6% of those who stayed to be seen were treated in triage with an order placed by the physician prior to seeing the physician. Age and gender were not associated with being seen. There was a significant relationship between race/ethnicity and being seen. And this study saw a relationship between LOS and seen. In conclusion, being seen and treated by the physician can decrease the number of return visits through evaluation and referral for underlying etiology of pain. Additional practice implications can include strategies aimed at effective pain management in triage and its impact on length of stay.
Spider mite mothers adjust reproduction and sons' alternative reproductive tactics to immigrating alien conspecifics

Maternal effects on environmentally induced alternative reproductive tactics (ARTs) are poorly understood but likely to be selected for if mothers can reliably predict offspring environments. We assessed maternal effects in two populations (Y and G) of herbivorous arrhenotokous spider mites Tetranychus urticae, where males conditionally express fighting and sneaking tactics in male–male combat and pre-copulatory guarding behaviour. We hypothesized that resident mothers should adjust their reproduction and sons’ ARTs to immigrating alien conspecifics in dependence of alien conspecifics posing a fitness threat or advantage. To induce maternal effects, females were exposed to own or alien socio-environments and mated to own or alien males. Across maternal and sons' reproductive traits, the maternal socio-environment induced stronger effects than the maternal mate, and G-mothers responded more strongly to Y-influence than vice versa. G-socio-environments and Y-mates enhanced maternal egg production in both populations. Maternal exposure to G-socio-environments demoted, yet maternal Y-mates promoted, guarding occurrence and timing by sons. Sneakers guarded earlier than fighters in Y-environments, whereas the opposite happened in G-environments. The endosymbiont Cardinium, present in G, did not exert any classical effect but may have played a role via the shared plant. Our study highlights interpopulation variation in immediate and anticipatory maternal responses to immigrants.
Repeated sex chromosome evolution in vertebrates supported by expanded avian sex chromosomes

Sex chromosomes have evolved from the same autosomes multiple times across vertebrates, suggesting that selection for recombination suppression has acted repeatedly and independently on certain genetic backgrounds. Here, we perform comparative genomics of a bird clade (larks and their sister lineage; Alaudidae and Panuridae) where multiple autosome–sex chromosome fusions appear to have formed expanded sex chromosomes. We detected the largest known avian sex chromosome (195.3 Mbp) and show that it originates from fusions between parts of four avian chromosomes: Z, 3, 4A and 5. Within these four chromosomes, we found evidence of five evolutionary strata where recombination had been suppressed at different time points, and show that stratum age explained the divergence rate of Z–W gametologs. Next, we analysed chromosome content and found that chromosome 3 was significantly enriched for genes with predicted sex-related functions. Finally, we demonstrate extensive homology to sex chromosomes in other vertebrate lineages: chromosomes Z, 3, 4A and 5 have independently evolved into sex chromosomes in fish (Z), turtles (Z, 5), lizards (Z, 4A), mammals (Z, 4A) and frogs (Z, 3, 4A, 5). Our results provide insights into and support for repeated evolution of sex chromosomes in vertebrates.