Miracle-dz/UniFAR-FTUs huggingface dataset:
Análisis de auralizaciones del nuevo órgano de la Basílica de San Jaume de Algemesí (Valencia)

Mediante el estudio de las condiciones acusticas de la Basilica de Sant Jaume de Algemesi (Valencia) con medidas y simulacion, se ha validado un modelo acustico. Con este modelo se ha realizado el calculo de auralizaciones simuladas mediante una grabacion anecoica del nuevo organo de este templo, que actualmente se encuentra en fase de construccion. Estas auralizaciones han permitido analizar, previamente a la instalacion del nuevo instrumento, las senales obtenidas a partir de la funcion de transferencia calculada mediante el modelo acustico de la iglesia. Este metodo podria utilizarse para determinar la reubicacion optima del organo o cualquier otra fuente sonora dentro del templo.
Design and evaluation of interactive audio-tactile maps for visually impaired people

In order to overcome challenges related to orientation and mobility, visually impaired people need to know their environment. Tactile relief maps are generally used for exploring geographic information, but they retain significant limitations. Recent technological progress allows the development of interactive maps which overcome these limitations. We designed an accessible interactive map prototype composed by a multi-touch screen with tactile map overlay and speech output. It provided auditory information when tapping on map elements. We have demonstrated in an experiment that our prototype was more effective and satisfactory for visually impaired users than a simple raised-line map. We also explored and tested different types of advanced non-visual interaction (gestural, tangible and wearable) for exploring the map. Finally, we present how this work has been conducted using a participatory design process.
The Benefit of Syntactic vs. Linear N-grams for Linguistic Description

Automatic dependency annotations have been used in all kinds of language applications. However, there has been much less exploitation of dependency annotations for the linguistic description of language varieties. This paper presents an attempt to employ dependency annotations for describing style. We argue that for this purpose, linear n-grams (that follow the text’s surface) alone do not appropriately represent a language like German. For this claim, we present theoretically as well as empirically founded arguments. We suggest syntactic n-grams (that follow the dependency paths) as a possible solution. To demonstrate their potential, we compare the German academic languages of linguistics and literary studies using both linear and syntactic n-grams. The results show that the approach using syntactic n-grams allows for the detection of linguistically meaningful patterns that do not emerge in a linear n-gram analysis, e. g. complex verbs and light verb constructions.
Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease

Aims: To identify specific gut bacteria associated with coeliac disease (CD) at diagnosis and after treatment with a gluten-free diet (GFD) in a paediatric population. Methods: 30 and 18 faecal samples from untreated and treated CD patients and 25 and 8 biopsy samples from untreated and treated CD patients, respectively, were analysed. In addition, 30 faecal and 8 biopsy samples from control children were evaluated for comparative purposes. Gut bacterial groups were quantified by real-time PCR. Results: Bacteroides and Clostridium leptum groups were more abundant in faeces and biopsies of CD patients than in controls regardless of the stage of the disease. E coli and Staphylococcus counts were also higher in faeces and biopsies of non-treated CD patients than in those of controls, but their levels were normalised after treatment with a GFD. Bifidobacterium levels were lower in faeces of both groups of CD patients and in biopsies of untreated CD patients compared to controls. Similar bacterial groups were related to CD in biopsies and faeces, indicating that faecal microbiota partly reflects that of the small intestine in CD patients, and could constitute a convenient biological index of this disorder. Conclusions: Duodenal and faecal microbiota is unbalanced in children with untreated CD and only partially restored after long-term treatment with a GFD, constituting a novel factor linked to this disorder.
A Time-Vertex Signal Processing Framework: Scalable Processing and Meaningful Representations for Time-Series on Graphs

An emerging way to deal with high-dimensional noneuclidean data is to assume that the underlying structure can be captured by a graph. Recently, ideas have begun to emerge related to the analysis of time-varying graph signals. This paper aims to elevate the notion of joint harmonic analysis to a full-fledged framework denoted as time-vertex signal processing, that links together the time-domain signal processing techniques with the new tools of graph signal processing. This entails three main contributions: a) We provide a formal motivation for harmonic time-vertex analysis as an analysis tool for the state evolution of simple partial differential equations on graphs; b) we improve the accuracy of joint filtering operators by up-to two orders of magnitude; c) using our joint filters, we construct time-vertex dictionaries analyzing the different scales and the local time-frequency content of a signal. The utility of our tools is illustrated in numerous applications and datasets, such as dynamic mesh denoising and classification, still-video inpainting, and source localization in seismic events. Our results suggest that joint analysis of time-vertex signals can bring benefits to regression and learning.
Multicore Resource Management

Current resource management mechanisms and policies are inadequate for future multicore systems. Instead, a hardware/software interface based on the virtual private machine abstraction would allow software policies to explicitly manage microarchitecture resources. VPM policies, implemented primarily in software, translate application and system objectives into VPM resource assignments. Then, VPM mechanisms securely multiplex, arbitrate, or distribute hardware resources to satisfy the VPM assignments.
The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit (*)

The DNA-dependent protein kinase (DNA-PK) requires for activity free ends or other discontinuities in the structure of double strand DNA. In vitro, DNA-PK phosphorylates several transcription factors and other DNA-binding proteins and is thought to function in DNA damage recognition or repair and/or transcription. Here we show that in vitro DNA-PK undergoes autophosphorylation of all three protein subunits (DNA-PKcs, Ku p70 and Ku p80) and that phosphorylation correlates with inactivation of the serine/threonine kinase activity of DNA-PK. Significantly, activity is restored by the addition of purified native DNA-PKcs but not Ku, suggesting that inactivation is due to autophosphorylation of DNA-PKcs. Our data also suggest that autophosphorylation results in dissociation of DNA-PKcs from the Ku-DNA complex. We suggest that autophosphorylation is an important mechanism for the regulation of DNA-PK activity.
Predicting nursing facility residents' quality of life using external indicators.

PURPOSE A newly developed brief measure of nursing facility (NF) resident self-reported quality of life (QOL) has been proposed for inclusion in a modified version of the minimum data set (MDS). There is considerable interest in determining whether it is possible to develop indicators of QOL that are more convenient and less expensive than direct, in-person interviews with residents. DESIGN AND METHODS QOL interview data from 2,829 residents living in 101 NFs using a 14-item version of a longer instrument were merged with data from the MDS and the Online Survey and Certification Automated Record (OSCAR). Bivariate and multivariate hierarchical linear modeling were used to assess the association of QOL with potential resident and facility level indicators. RESULTS Resident and facility level indicators were associated with self-reported QOL in the expected direction. At the individual resident level, QOL is negatively associated with physical function, visual acuity, continence, being bedfast, depression, conflict in relationships, and positively associated with social engagement. At the facility level, QOL is negatively associated with citations for failing to accommodate resident needs or providing a clean, safe environment. The ratio of activities staff to residents is positively associated with QOL. This study did not find an association between QOL and either use of restraints or nurse staff levels. Approximately 9 percent of the total variance in self-reported QOL can be attributed to differences among facilities; 91 percent can be attributed to differences among residents. Resident level indicators explained about 4 percent of the variance attributable to differences among residents, and facility factors explained 49 percent of the variance attributable to differences among NFs. However, the different variables explained only 10 percent of the variance in self-reported QOL. IMPLICATIONS A brief self-report measure of NF resident QOL is consistently associated with measures that can be constructed from extant data sources. However, the level of prediction possible from these data sources does not justify reliance on external indicators of resident QOL for policy purposes.
Abrogation of Src Homology Region 2 Domain-Containing Phosphatase 1 in Tumor-Specific T Cells Improves Efficacy of Adoptive Immunotherapy by Enhancing the Effector Function and Accumulation of Short-Lived Effector T Cells In Vivo

T cell expression of inhibitory proteins can be a critical component for the regulation of immunopathology owing to self-reactivity or potentially exuberant responses to pathogens, but it may also limit T cell responses to some malignancies, particularly if the tumor Ag being targeted is a self-protein. We found that the abrogation of Src homology region 2 domain-containing phosphatase-1 (SHP-1) in tumor-reactive CD8+ T cells improves the therapeutic outcome of adoptive immunotherapy in a mouse model of disseminated leukemia, with benefit observed in therapy employing transfer of CD8+ T cells alone or in the context of also providing supplemental IL-2. SHP-1−/− and SHP-1+/+ effector T cells were expanded in vitro for immunotherapy. Following transfer in vivo, the SHP-1−/− effector T cells exhibited enhanced short-term accumulation, followed by greater contraction, and they ultimately formed similar numbers of long-lived, functional memory cells. The increased therapeutic effectiveness of SHP-1−/− effector cells was also observed in recipients that expressed the tumor Ag as a self-antigen in the liver, without evidence of inducing autoimmune toxicity. SHP-1−/− effector CD8+ T cells expressed higher levels of eomesodermin, which correlated with enhanced lysis of tumor cells. Furthermore, reduction of SHP-1 expression in tumor-reactive effector T cells by retroviral transduction with vectors that express SHP-1–specific small interfering RNA, a translatable strategy, also exhibited enhanced antitumor activity in vivo. These studies suggest that abrogating SHP-1 in effector T cells may improve the efficacy of tumor elimination by T cell therapy without affecting the ability of the effector cells to persist and provide a long-term response.
Irinotecan Pathway Genotype Analysis to Predict Pharmacokinetics 1

Purpose: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan. Experimental Design: Irinotecan was administered to 65 cancer patients as a 90-min infusion (dose, 200–350 mg/m), and pharmacokinetic data were obtained during the first cycle. All patients were genotyped for variants in genes encoding MDR1 P-glycoprotein (ABCB1), multidrug resistance-associated proteins MRP-1 (ABCC1) and MRP-2 (canalicular multispecific organic anion transporter; ABCC2), breast cancer resistance protein (ABCG2), carboxylesterases (CES1, CES2), cytochrome P450 isozymes (CYP3A4, CYP3A5), UDP glucuronosyltransferase (UGT1A1), and a DNA-repair enzyme (XRCC1), which was included as a nonmechanistic control. Results: Eighteen genetic variants were found in nine genes of putative importance for irinotecan disposition. The homozygous T allele of the ABCB1 1236C>T polymorphism was associated with significantly increased exposure to irinotecan (P 0.038) and its active metabolite SN-38 (P 0.031). Pharmacokinetic parameters were not related to any of the other multiple variant genotypes, possibly because of the low allele frequency. The extent of SN-38 glucuronidation was slightly impaired in homozygous variants of UGT1A1*28, although differences were not statistically significant (P 0.22). Conclusions: It is concluded that genotyping for ABCB1 1236C>T may be one of the factors assisting with dose optimization of irinotecan chemotherapy in cancer patients. Additional investigation is required to confirm these findings in a larger population and to assess relationships between irinotecan disposition and the rare variant genotypes, especially in other ethnic groups.
Crystal Nucleation by Laser-Induced Cavitation

High-speed and high-resolution photography have been used to investigate the relationship between creation, expansion, and collapse of a vapor cavity induced by a 6 ns laser pulse and the subsequent nucleation of crystals. A thin layer of supersaturated aqueous solutions of (NH4)2SO4 and KMnO4 was confined between two glass plates with a separation of 50 and 100 μm. The expansion and collapse of the laser-induced vapor bubble occurred over a total time scale of 200 μs, while the first identifiable crystal appears one second after the laser pulse. Crystals were observed to form on a ring with a diameter of 70 μm centered in the focal point of the laser. The ring is preceded by an optical disturbance observed through the cavity around 30–50 μs after the laser pulse and vapor cavity formation. This ring-shaped optical disturbance originates from changes in refractive index induced by crystal nuclei formation. The formation of the nuclei most probably coincides with the formation of the bubble, when the rate of evaporation and the supersaturation are at their maxima. Apparently, it takes the nuclei around 30–50 μs to grow to a particle size with a visible optical disturbance
Transient graft-versus-host reaction in the treatment of leukemia in mice.

Inbred RF mice, each bearing a transplanted myeloid leukemia, received 530 rads of X rays and then injections of C57BL spleen cells (10-60 X 10) and bone marrow cells (40-60 X 10). Most of these animals died with clinical and histological signs of secondary disease. Leukemia incidence, as judged by morphological criteria, varied with the spleen cell dose and ranged between 50% and o. The severity of the secondary disease could be diminished, without recurrence of leukemia, by the immunosuppressive agents cyclophosphamide and heterologous anti· lymphocyte serum. Administration of recipient-type hematopoietic cells and blood after the course of cyclophosphamide abolished the chimeric state and prevented secondary disease, without recurrence of the leukemia. It is concluded that, in the experimental system used, permanent chimerism and the chronic graft-versus-host reaction are not necessarily prerequisite to the suppression of a transplanted leukemia. -J Nat Cancer Inst 41: 421-437, 1968.
Energy-efficient medium access for wireless sensor networks under slow fading conditions

In this work, we first study and then propose an optimal version on the medium access control mechanism known as carrier sense multiple access with collision avoidance (CSMA/CA). This protocol is adopted by many wireless communication standards, such as the IEEE 802.11 series and IEEE 802.15. 4 (ZigBee). We first identify its drawbacks in a slow fading channel environment, and show that the CSMA/CA can be very energy-inefficient, especially in many wireless sensor network (WSN) applications where the traffic demand is low. In particular, we study communication over a Rayleigh fading channel, which we model by means of a time invariant Markov process. We then show that the decision regarding the optimal access time on such a channel can be formulated as an optimization problem, and that an optimal solution can be accurately derived. We also simulate a ZigBee node in a Rayleigh fading environment and the result shows that optimum channel access can save significant amount of energy compared to conventional CSMA/CA.
Clotting on the outer surfaces of vascular catheters.

Thrombotic and embolic accidents are serious complications of vascular catheterizations. Some of these complications are caused by the stripping of clot from the surface of the catheters as these catheters are withdrawn through the holes in the vascular walls (Fig. 1). The purpose of this work was to investigate the rate of clotting on the surface of various catheters and to find possible means of prevention. The catheters studied were those commonly employed in clinical catheterization, namely nonradiopaque polyethylene, nonradiopaque Teflon, radiopaque polyethylene of Swedish manufacture, radiopaque polyethylene of American manufacture, radiopaque Teflon, woven Rodriguez Alvarez coated with a “special compound,” woven directable Cordis catheters (probably covered with polyurethane), and Silastic medical grade tubing. All catheters were No. 7 French. Technic Under general anesthesia, the carotids and the jugular veins of large dogs were isolated as far as possible toward the head and toward the chest. On.
Fully integrated radio over fiber downlink for distributed multi-antenna systems in 65 nm CMOS

This paper presents a fully integrated downlink for low-cost remote antenna units in fiber-fed distributed multi-antenna systems. To reduce the cost of optical parts, an intermediate frequency (IF) signal is distributed over the fiber, and the circuit consists of an optical receiver, a single side-band frequency up-converting radio transmitter, and LO generation circuitry. The optical to electrical conversion gain (V/W) of the system is 59 dB, and an output referred 1 dB compression point of +6 dBm and an OIP3 of +17 dBm are measured. The SFDR of the circuit is 96.5 dB·Hz2/3. The phase noise of the PLL measured at 4.2 GHz is -145 dBc/Hz at 20 MHz offset, where as the reference spur level is -58 dBc. The circuit is fabricated in a standard 65 nm CMOS process and occupies just 0.8 mm2 of chip area including bond pads.
State feedback control AQM algorithm based on T-S fuzzy model

Considering the nonlinear characteristic of network congestion control system, a network congestion control system model is constructed using T-S fuzzy model, which can approach nonlinear system very well. A new active queue management algorithm is designed using state feedback control based on this model. The design method of proposed AQM algorithm is described in detail. The stability analysis and parameters selection are given. Simulation results show that the proposed algorithm has fast convergence speed, better stability and robustness to network loads varying. The compare with PI, PID, REM shows that the proposed algorithm has fast response speed, smaller steady state queue length variation and better robustness.
Mesure de la perfusion cérébrale par Arterial Spin Labeling après un infarctus cérébral et impact sur le pronostic fonctionnel, cognitif et moteur à trois mois

Objectifs. Determiner la faisabilite de l'ASL au CHU de Bordeaux apres un infarctus cerebral (IC), et evaluer la correlation entre le statut perfusionnel et le pronostic clinique, en tenant compte des caracteristiques de l'IC et des lesions associees : leucoencephalopathie (LEP), microbleeds (MB), lacunes, espaces de Virchow-Robin dilates et atrophie hippocampique (AH). Methodes. Les patients presentant un IC hemispherique entre 24 et 72 heures ont ete inclus consecutivement. Un protocole d'imagerie IRM 3T, comprenant des sequences pseudo continues ASL (pCASL) a ete mis en place. L'evaluation clinique a ete faite a la phase initiale et a 3 mois par des tests explorant l'autonomie, la motricite, les fonctions cognitives, et l'etat thymique. Les debits sanguins cerebraux (CBF) ont ete correles a la clinique, aux caracteristiques de l'IC et aux lesions associees. Resultats. 57 patients ont ete inclus. L'ASL a pu etre interpretee chez 52 patients. Il existait une grande variabilite interindividuelle de CBF. 23 sujets avaient un pattern d'hypoperfusion au sein de l'IC, 29 avaient un pattern d'hyperperfusion. L'alteration de la fluence verbale etait plus marquee dans le groupe Hypoperfusion (p=0.041), avec une tendance a un plus mauvais pronostic fonctionnel. Dans ce groupe, les patients hypertendus etait plus nombreux (p=0.045), la LEP peri-ventriculaire plus severe (p=0.007), le nombre de MB plus grand (p=0.002). L'hyperperfusion etait associee a une plus grande frequence de remaniement hemorragique (22.73% versus 9.09%). La severite de la LEP et de l'AH etait correlee a un pronostic clinique moins bon. Conclusion. La 3T pCASL est une technique realisable au CHU de Bordeaux a la phase subaigue d'un IC hemispherique. L'existence d'une hypoperfusion persistante au-dela de la 24e heure post-IC est associee a une alteration du pronostic clinique a 3 mois, significatif pour la fluence verbale et avec une tendance pour le pronostic fonctionnel global.
A goal-oriented framework for business modeling

This paper proposes a modeling framework that provides rigorous concepts for conducting early organizational requirements analysis. The aim is to allow business analysts to produce an organizational model that precisely captures the knowledge of an organization and of its business processes. To this end, the framework offers a conceptual meta-model that identifies constructs that enable capturing the intrinsic characteristics of an organization setting for a corporate information system-to-be. The approach allows the analyst to have a holistic perspective integrating human and organizational aspects to gain better understanding of business system inner and outer modelling issues. The framework takes roots in both management theory and requirements analysis. It helps bridging the gap between enterprise and requirements models proposing an integrated vision, comprehensive and expressive to both managers and software (requirements) analysts.
Test scheduling for high performance VLSI system implementations

A powerful suboptimum heuristic for scheduling tests on general-purpose high-performance VLSI system implementations is presented. A simple model that represents a system and its organization, at any level, by a labeled resource allocation graph between test functions and test and system resources was introduced. The resource allocation graph was utilized to produce a scheduling model and a simple schedulability condition. An algorithm based on mechanisms for generating optimum schedules was presented. The algorithm performs a preliminary greedy scan for valid scheduling cycles. The partial scan seeds an iterative improvement procedure which utilizes a controlled incremental departure from local optima to schedule functions that require an equal number of tests. Methods to utilize the algorithm for a general number of tests per function were also outlined. The implementation of an experimental version of the algorithm showed good performance. <<ETX>>