Miracle-dz/UniFAR-FTUs huggingface dataset:
Linoleic acid and risk of sudden cardiac death.

OBJECTIVE--To test the hypothesis that the essential fatty acid, linoleic acid, measured in adipose tissue as an indicator of long term dietary intake, is inversely related to the risk of sudden cardiac death. DESIGN--A population case-control study. SETTING--A regional health district. SUBJECTS--84 men (age 25-64 years) who died instantaneously or within 24 hours of the onset of symptoms with no history of coronary heart disease or medically treated hyperlipidaemia, and in whom coronary artery disease was diagnosed at postmortem examination as the primary cause of death, were compared with 292 age (to within two years) and sex matched healthy controls and their partners drawn from the general practitioners' records with whom the cases were registered. MAIN OUTCOME MEASURES--Fatty acid composition of adipose tissue and the risk of sudden cardiac death. RESULTS--Linoleic acid in adipose tissue was inversely related to the risk of sudden cardiac death. The estimated relative risk (95% CI) of sudden cardiac death was 5.7 (1.8 to 17.9) for the lowest quintile and 4.0 (1.2 to 12.9) for the next quintile of adipose linoleic acid in the control population when compared with the highest quintile. This inverse relation was independent of age, reported smoking habits, history of hypertension, and diabetes, although there was a close association with cigarette smoking. The estimated adjusted proportionate increase in risk (95% CI) of sudden cardiac death was 1.14 (1.03 to 1.23) for every 1% reduction of linoleic acid in adipose tissue. CONCLUSIONS--The percentage content of linoleic acid in adipose tissue was inversely related to the risk of sudden cardiac death. Populations with a high risk of sudden cardiac death may benefit from increasing their dietary intake of polyunsaturated fatty acid oils, principally from cereals and vegetables.
The ‘anatomic shunt test’ in clinical practice; contemporary description of test and in-service evaluation

The 100% oxygen shunt test for detecting right-to-left anatomical shunting was originally described 70 years ago. However, its clinical value is not yet established. We conducted an audit in 80 patients undergoing the test between 1996 and 2012 in a tertiary referral centre. A significant difference (p=0.02) existed between the median shunt percentages where anatomical shunting was identified (10.2%) and absent (5.0%). The area under the curve for a ROC plot was 0.70. A shunt percentage of 8.3 had a sensitivity of 80% and specificity of 75% for detection of an anatomic shunt. We conclude the test is satisfactory for the first-line investigation for anatomic shunting.
Mammosomatotropes: presence and functions in normal and neoplastic pituitary tissue.

I. Introduction MORE than a half century has passed since Romeis first proposed the “one cell-one hormone” theory which holds that each of the major pituitary hormones is produced by a separate and distinct cell type (1). Consistent with this idea, the acidophilic staining cells (termed acidophils) of the adenohypophysis have been traditionally subdivided into two categories, those that secrete only GH and others that produce just PRL. This view was supported by considerable tinctorial evidence available at the time of Romeis' hypothesis and generated in the subsequent three decades (1–5). Moreover, data produced throughout the 1970s and early 1980s by the use of light microscopic immunocytochemistry (ICC) and immunofluorescence were generally consonant with the one cell-one hormone theory, except in the case of certain pituitary tumors (6–8). The presence of bihormonal acidophils in this latter situation was attributed to aberrant mechanisms attendant to the neoplastic condition. However, as will be disc.
Coexisting High-grade Vulvar Intraepithelial Neoplasia (VIN) and Condyloma Acuminatum: Independent Lesions Due to Different HPV Types Occurring in Immunocompromised Patients

The majority of vulvar intraepithelial neoplasia (VIN) is high-grade and is related to high-risk human papillomavirus (HRHPV) (most commonly HPV 16). It is considered to be the precursor of HRHPV-related vulvar squamous cell carcinoma. Vulvar condyloma acuminatum is low-risk HPV (LRHPV)-related (most commonly types 6 and 11) and has virtually no risk of neoplastic progression. While infection with multiple LRHPV and HRHPV types has been reported for cervical squamous intraepithelial lesions, coexisting vulvar condyloma and adjacent high-grade VIN have not been well characterized. Eleven cases of concurrent condyloma acuminatum and adjacent flat high-grade VIN and 3 cases of high-grade VIN with prominent condylomatous architecture were analyzed using immunohistochemical analysis of p16 expression, in situ hybridization (ISH) for HPV detection [HPV 6/11, HPV 16, HPV 18, and HPV wide spectrum (types 6, 11, 16, 18, 31, 33, 35, 45, 51, 52) probes], and HPV typing by a polymerase chain reaction (PCR)-based method (in select cases). All patients had underlying immunosuppressive conditions (human immunodeficiency virus infection or posttransplant therapy). Among the 11 cases of concurrent high-grade VIN and condyloma, the lesions were directly adjacent to one another in 5 cases (with 2 of these demonstrating an intimate admixture of lesions), and in 6 cases the lesions were found in separate tissue sections from the same specimen. Diffuse/strong p16 expression was seen in all high-grade VIN lesions, whereas patchy/weak staining was found in all condylomata. All condylomata contained HPV 6 or 11 as detected by ISH. HRHPV was detected in all of the accompanying high-grade VIN lesions. Ten contained HPV 16 (9 by ISH, 1 by PCR), with the remaining case containing multiple HPV types by PCR. All condylomatous high-grade VIN lesions demonstrated diffuse/strong p16 expression and had evidence of HRHPV (1 with HPV 16 by ISH, 1 with HPV 18 by ISH, and 1 with multiple HPV types by PCR), with no detection of HPV 6 or 11 by ISH. The restriction of LRHPV to condylomatous components and HRHPV to high-grade VIN components of adjacent lesions suggests these are independent lesions caused by different HPV types. Diffuse p16 expression can highlight small foci of high-grade VIN, which may be overlooked in more abundant condylomatous tissue from immunosuppressed patients. The presence of only HRHPV in those VIN lesions with high-grade cytologic features but prominent condylomatous architecture supports their classification as forms of pure high-grade VIN and distinguishes them from condyloma acuminatum.
A fuzzy neural network model based on fuzzy clustering and its applications

Fuzzy neural network, which is based on fuzzy theory and BP neural network, plays an important role in practical. But the difficulty is how to construct its structure model. In this paper, according to the hypostasis of hidden layer, a fuzzy neural network model based on fuzzy clustering is brought forward, in which features of the samples are extracted and output information is synthetically considered. And a satisfied result is reached in the application of oil-gas recognition in Tarim Oilfield.
Does local recurrence affect the rate of distant metastases and survival in patients with early‐stage breast carcinoma treated with breast‐conserving therapy?

The purpose of the current analysis was to evaluate the impact of local recurrence (LR) on the development of distant metastases (DM), overall survival (OS), and cause specific survival (CSS) in patients with early‐stage breast carcinoma who underwent conservative surgery (CS) and received postoperative radiotherapy (RT).
High-precision localization and quantification of 3D tubular structures

We derive analytic lower bounds for estimating the position and width of 3D tubular structures. Based on a continuous image model comprising blur and noise introduced by an imaging system we analyze three different intensity models of 3D tubular structures with increasing complexity. The derived formulas indicate that quantification of 3D tubular structures can be performed with very high precision under certain assumptions. The theoretical results are substantiated by experimental investigations based on discretized and quantized 3D image data
Hearing Preservation Surgery for Cochlear Implantation: A Meta-analysis

Objective To examine the results of hearing preservation in cochlear implantation surgery to identify surgical technical factors, electrode array design factors, and steroid usage, which predicts greater low-frequency hearing preservation. Data sources A thorough search of Medline and Pubmed of English studies from January 1, 1995, to January 1, 2013, was performed using the key words “electric and acoustic hearing” or “hybrid cochlear implant” or “EAS cochlear implant” or “partial deafness cochlear implant” or “bimodal hearing cochlear implant” or “hearing preservation cochlear implant. ” Study selection The meta-analysis was conducted according to the PRISMA statement. Only articles in English were included. Studies were included if hearing preservation was the primary end point. A final number of 24 studies met the inclusion criteria. Data extraction Patient populations were analyzed as intention to treat. Data were extracted from raw audiograms where possible. Data were excluded if not all explanatory variables were present or if variable values were ambiguous. Data synthesis The weighted least-squares regression method was used to determine the predictive power of each explanatory variable across all studies. Conclusion In this meta-analysis, the following are associated with better hearing preservation: cochleostomy over the round window approach, posterior tympanotomy over the suprameatal approach, a slow electrode array insertion technique over insertion of less than 30 seconds, a soft tissue cochleostomy seal over a fibrin glue only seal and the use of postoperative systemic steroids. Longer electrode arrays, topical steroid use, and lubricant use for electrode array insertion did not give an advantage.
Type IV hypersensitivity reaction following Cyanoacrylate Glue Embolization (VenaSealTM) of the Great Saphenous Vein incompetence: A case report

Background: In recent years, cyanoacrylate glue embolization (CAE) (VenaSealTM, Medtronic, Santa Rosa, USA) has emerged as an effective and safe strategy in the management of chronic venous insufficiency and varicose veins. The most common complication is a self-limiting post-procedure phlebitis, which often resolves in a few days. In rare instances, the rash persists for weeks and is believed be attributed to a delayed hypersensitivity reaction to cyanoacrylate. Method: We present a short report of a female patient who developed such a rash following CAE 3 weeks after VenaSeal? treatment. Result: The patient made a complete self-limiting recovery of her rash after 2 weeks following expectant management with non-steroidal anti-inflammatories (NSAID) and analgesia. Conclusion: The VenaSealTM red skin reaction should be suspected in patients developing a rash post-CAE. This may be related to a delayed hypersensitivity reaction to the acrylate component of the compound.
Modeling Disordered Materials with a High Throughput ab-initio Approach

Abstract : Predicting material properties of disordered systems remains a long-standing and formidable challenge in rational materials design. To address this issue, we introduce an automated software framework capable of modeling partial occupation within disordered materials using a high-throughput(HT) first principles approach. At the heart of the approach is the construction of supercells containing a virtually equivalent stoichiometry to the disordered material. All unique supercell permutations are enumerated and material properties of each are determined via HT electronic structure calculations. In accordance with a canonical ensemble of supercell states, the framework evaluates ensemble average properties of the system as a function of temperature. As proof of concept, we examine the frameworks final calculated properties of a zinc chalcogenide, a wide-gap oxide semiconductor, and an iron alloy at various stoichiometries.
Coevolution of farming and private property during the early Holocene

The advent of farming around 12 millennia ago was a cultural as well as technological revolution, requiring a new system of property rights. Among mobile hunter–gatherers during the late Pleistocene, food was almost certainly widely shared as it was acquired. If a harvested crop or the meat of a domesticated animal were to have been distributed to other group members, a late Pleistocene would-be farmer would have had little incentive to engage in the required investments in clearing, cultivation, animal tending, and storage. However, the new property rights that farming required—secure individual claims to the products of one’s labor—were infeasible because most of the mobile and dispersed resources of a forager economy could not cost-effectively be delimited and defended. The resulting chicken-and-egg puzzle might be resolved if farming had been much more productive than foraging, but initially it was not. Our model and simulations explain how, despite being an unlikely event, farming and a new system of farming-friendly property rights nonetheless jointly emerged when they did. This Holocene revolution was not sparked by a superior technology. It occurred because possession of the wealth of farmers—crops, dwellings, and animals—could be unambiguously demarcated and defended. This facilitated the spread of new property rights that were advantageous to the groups adopting them. Our results thus challenge unicausal models of historical dynamics driven by advances in technology, population pressure, or other exogenous changes. Our approach may be applied to other technological and institutional revolutions such as the 18th- and 19th-century industrial revolution and the information revolution today.
A study on moderating effect of personal innovativeness in mobile-RFID services

In this study, we attempt to explore the intention of using mobile-RFID services based on the Warshaw's purchase intention model. We focus on a personal innovativeness in the domain of IT (PIIT) because personal innovativeness could be a key factor of telecommunication services usage. According to Agarwal and Prasad (1998), PIIT serves as a key moderator in technology acceptance behavior. Thus, we examine whether PIIT has moderation effect on purchasing mobile-RFID services. The result shows that both purchasability and perceived need have a positive effect on purchase intention of mobile-RFID services. PIIT serves to moderate the relationship between perceived need and purchase intention of mobile-RFID services.
Team Based Learning: An Innovative Teaching Strategy for Enhancing Students' Engagement

Background: Team based learning is a strategy that combines features of student-centeredness and problem solving attributes. It also enhances students’ engagement which achieve desired outcomes such as retention; academic achievement and improved critical thinking. Aim: The present study aimed to investigate the effect of implementing team based learning on students' engagement in nursing administration course. Subjects and Methods: A quasi experimental design was used. The study sample included 251 students who were studied nursing administration course during the first term of academic year 2015/2016, they were divided into two groups: experimental group (n=128) and control group (n=123). Data was collected by using four tools: Team based learning knowledge questionnaire, Readiness Assurance Test for Team based learning, Students' engagement questionnaire, Preference between team based learning and traditional learning questionnaire. Results: There was highly statistically significant difference between experimental and control groups regarding academic challenges, active and collaborative learning, students staff interactions and total students' engagement domains . there was no statistically significant difference between experimental and control groups regarding enriching educational experiences and supportive learning environment domains. The majority students of experimental group preferred team based learning more than traditional learning. Conclusion: Implementing team-based learning method in nursing administration course enhances students' engagement, especially academic challenges, active and collaborative, student-staff interactions domains. The majority of the students were preferred team based learning method more than traditional method. Recommendations: Team based learning method should be implemented in nursing administration course and other nursing courses in the faculty. Feedback questionnaire should be administered to collect views of students and meeting with students to let them express about their opinions after studying assigned courses.
A Generalizable Strategy for the 3D Bioprinting of Hydrogels from Nonviscous Photo‐crosslinkable Inks

An in situ crosslinking strategy is used for 3D bioprinting of nonviscous photo-crosslinkable hydrogels. This method can be generalized to various photo-crosslinkable formulations, maintaining high embedded cell viability and tunable cell behavior. Heterogeneous and hollow filaments can be printed using this strategy, allowing fabrication of complex engineered cell-laden constructs.
Effects of Barrier Application of Granular Deltamethrin on Subadult Ixodes scapularis (Acari: Ixodidae) and Nontarget Forest Floor Arthropods

Abstract We evaluated the effects of a single application of granular deltamethrin made against nymphal Ixodes scapularis Say on the diversity and abundance of forest arthropods taken in pitfall traps in oak forest sites for 16 wk after treatment in central New Jersey. Control of I. scapularis subadults on treated plots ranged between 97 and 100% and continued at least 12 wk postapplication. Significant short-term changes in arthropod assemblages were detected at one of three study sites within 4 wk posttreatment. Effects were not distributed equally across taxa. Seasonal changes in numbers and diversity of forest arthropods in the study areas may have affected the impact of the acaricide in the treatment area. Comparison with control areas indicated that reductions in abundance of some arthropod taxa in the treatment area were detectable 12 wk after treatment. Total arthropod species diversity was not significantly affected by the application, and no treatment effects were detected 16 wk postapplication, suggesting that the arthropod community had recovered from the effects of the application. The merits of barrier applications in integrated tick control programs are discussed.
A problematic animal fossil from the early Cambrian Hetang Formation, South China

Abstract. The lower-middle Hetang Formation (Cambrian Stage 2–3) deposited in slope-basinal facies in South China is well known for its preservation of the earliest articulated sponge fossils, providing an important taphonomic window into the Cambrian Explosion. However, the Hetang Formation also hosts a number of problematic animal fossils that have not been systematically described. This omission results in an incomplete picture of the Hetang biota and limits its contribution to the understanding of the early evolution of animals. Here we describe a new animal taxon, Cambrowania ovata Tang and Xiao, new genus new species, from the middle Hetang Formation in the Lantian area of southern Anhui Province, South China. Specimens are preserved as carbonaceous compressions, although some are secondarily mineralized. A comprehensive analysis using reflected light microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and micro-CT reveals that the new species is characterized by a spheroidal to fusoidal truss-like structure consisting of rafter-like crossbars, some of which are secondarily baritized and may have been internally hollow. Some specimens have aperture-like structures that are broadly similar to oscula of sponges, whereas others show evidence of a medial split reminiscent of gaping carapaces. While the phylogenetic affinity of Cambrowania ovata Tang and Xiao, n. gen. n. sp. remains problematic, we propose that it may represent carapaces of bivalved arthropods or more likely sponges in early life stages. Along with other problematic metazoan fossils such as hyolithids and sphenothallids, Cambrowania ovata Tang and Xiao, n. gen. n. sp. adds to the diversity of the sponge-dominated Hetang biota in an early Cambrian deepwater slope-basinal environment.
Expression of Variability in Corn as Influenced by Growth Stage Using Optical Sensor Measurements

Improving crop management inputs with remote sensing devices is an emerging technology. This study documented the progression of the normalized difference vegetative index (NDVI) during the life cycle of corn (Zea mays L.), evaluated the spatial variability of corn growth in terms of the CV (calculated from NDVI readings), and documented the relationships between NDVI,CV (calculated from NDVI), and grain and biomass yields and plant density. Four rows, 30 m in length, from two locations during 2 yr were randomly selected for this study. An optical sensor was used to collect NDVI readings at multiple growth stages during the life cycle of corn. The NDVI increased with progression of vegetative growth stages until V10, where a plateau was encountered, followed by a decline in NDVI after the VT growth stage. Coefficient of variation data from the NDVI readings revealed two dominant peaks during the life cycle of corn, one between the V6 and V8 growth stages and the second during the late reproductive growth stages. The CV data illustrated that the greatest variation expressed by corn during the vegetative growth stages was between the V6 and V8 growth stages. The highest correlation of NDVI with corn grain yield was found at the V7 to V9 growth stages; likewise, CV and plant density were also more highly correlated from V7 to V9. The CV from NDVI readings was highly correlated with grain and biomass yields at all growth stages.
Variations of Aminopeptidase Activity in Granulation Tissue and in Serum of Rats During Wound Healing: A Correlated Histochemical and Quantitative Study.

A histochemical study of the early stages of healing of induced cutaneous wounds in the rat has shown that proliferating connective tissue cells involved in repair contain leucine aminopeptidase.1'2 The demonstration of an aminopeptidase in the normal fibroblast and in the cells of granulation tissue has provided a new parameter in an easily inducible biologic system. " The main purpose of the present study was to correlate histochemical and quantitative variations of aminopeptidase activity in serum and in the granulation tissue and scar of cutaneous wounds in rats. The experiments were designed to establish whether aminopeptidase activity of granulation tissue varied with the sequence of cellular changes leading to scar formation; to assess changes in the aminopeptidase levels of serum during the process of wound healing; and to gain further insight into the cytochemical distribution of aminopeptidase in proliferating connective tissue cells.