Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacokinetics of 3,5,3'-triiodothyroacetic acid and its effects on serum TSH levels.

3,5,3'-triiodothyroacetic acid is an effective inhibitor of TSH secretion in central hyperthyroidism. Serum, 3,5,3'-triiodothyroacetic acid was measured with an RIA preceded by immunoprecipitation. An anti-3,5,3'-triiodothyroacetic acid antibody was obtained in rabbits, using 3,5,3'-triiodothyroacetic acid coupled to hemocyanin and diazotized benzidine as antigen (cross-reactivity with T4, T3, tetraiodothyroacetic acid was 0.2, 1.1, and 5%, respectively). Endogenous 3,5,3'-triiodothyroacetic acid levels could not be detected in 14 euthyroid, 10 hypothyroid and 10 hyperthyroid sera (detection limit 0.055 nmol/l). Kinetic studies were performed in 6 healthy male subjects who received an oral and an iv dose of 1050 micrograms of 3,5,3'-triiodothyroacetic acid. The serum measurements were analysed according to a non-compartmental method. The half-life of 3,5,3'-triiodothyroacetic acid was 6 h 22 min +/- 29 min, the volume of distribution was 114 +/- 9 1/70 kg, and the plasma clearance rate was 298 +/- 141. (70 kg)-1.day-1. Highest 3,5,3'-triiodothyroacetic acid levels were measured after 40 min (for T3 2-3 h) and its absorption was 67 +/- 6%. The nadir of the mean TSH levels was 0.72 +/- 0.09 mU/l 6 h after 3,5,3'-triiodothyroacetic acid administration. However, the time course of serum TSH response did not differ from that obtained after administration of 37.5 micrograms T3. The dose-response effect for TSH was studied using oral doses of 350, 700, 1400 and 2800 micrograms 3,5,3'-triiodothyroacetic acid. TSH was measured 9 h after 3,5,3'-triiodothyroacetic acid administration at 17.00 h, and compared with control serum TSH levels obtained at 08.00 h (1.53 +/- 0.11) and at 17.00 h the day before the test (1.87 +/- 0.11). They were 1.05 +/- 0.15 (N = 9, mean +/- SEM), 0.83 +/- 0.08 (N = 24), 0.66 +/- 0.06 (N = 24), and 0.43 +/- 0.02 mU/l (N = 6), respectively. In conclusion, TSH inhibition by 3,5,3'-triiodothyroacetic acid is similar to T3, with a potency ratio of 1 to 18.
Acute and persistent postoperative pain after breast surgery.

OBJECTIVES This study's primary aim was to determine levels of acute and persistent postoperative pain and the incidence of severe postoperative pain after mastectomy. A secondary aim was to examine factors associated with postoperative pain. DESIGN A retrospective cohort study of 196 female breast surgery subjects was conducted. Data were collected on: numerical rating scale (NRS) pain scores in the Post Anesthesia Care Unit (PACU) and at 1 month and 6-12 months postoperative; age; race; insurance; obesity; radiotherapy; chemotherapy; hypertension; anesthesia care time; and intraoperative and PACU opioid use. Severe postoperative pain was defined as NAS > or = 5. Data were analyzed using chi square, Fisher's exact test or analysis of variance, with alpha = 0.05. RESULTS PACU pain and the incidence of severe PACU pain increased with surgical complexity (P < 0.005). PACU pain scores averaged 4.71 +/- 0.24 and 57.7% of subjects experienced severe pain. Postoperative pain scores at 1 or 6-12 months did not vary by surgical complexity and averaged 2.21 +/- 0.32 and 0.74 +/- 0.22, respectively. Severe postoperative pain was experienced by 22.1% of subjects at 1 month and 8.2% of subjects at 6-12 months. Older age and systolic hypertension were associated with less PACU pain. Non-White race, obesity, and high PACU opioid use were associated with greater postoperative pain at 1 month. Non-White people also had greater postoperative pain at 6-12 months. CONCLUSIONS The results suggest that nearly 60% of breast surgery patients experience severe acute postoperative pain, with severe pain persisting for 6-12 months in almost 10% of patients.
Glucocorticoids antagonize insulin's antiproteolytic action on skeletal muscle in humans.

Although chronic glucocorticoid elevations cause net skeletal muscle protein loss in man, the kinetic mechanisms responsible for this catabolic effect and the capacity of insulin to overcome it remain unclear. To examine this issue, we measured basal and insulin-stimulated rates of protein synthesis and breakdown in muscle using the phenylalanine forearm kinetic method in eight normal volunteers studied postabsorptively and after 4 days of dexamethasone treatment (8 mg/day). To avoid the confounding effects of systemic insulinization, local forearm insulin levels were raised by approximately 430 pmol/L using a 150-min brachial arterial infusion of insulin (0.251 pmol/kg.min). Postabsorptively, dexamethasone produced mild hyperglycemia (P < 0.003) and a 3-fold rise in plasma insulin (P < 0.001), but no change in forearm phenylalanine balance or kinetics. Before dexamethasone treatment, local hyperinsulinemia increased forearm glucose uptake 2.5-fold and caused a positive net balance of phenylalanine due to a marked 40% inhibition of proteolysis. After dexamethasone treatment, forearm glucose uptake was modestly reduced. However, forearm net phenylalanine balance remained negative due to a striking reduction in insulin's inhibitory effect on proteolysis. We conclude that 1) the effects of glucocorticoid on basal muscle protein turnover are minimized by compensatory hyperinsulinemia, and 2) glucocorticoids cause muscle resistance to insulin's antiproteolytic action.
The SeaView security model

A formal security policy model that uses basic view concepts for a secure multilevel relational database system is described. The model is formulated in two layers, one corresponding to a security kernel of reference monitor that enforces mandatory security, and the other defining multilevel relations and formalizing policies for labeling new and derived data, data consistency, discretionary security, and transaction consistency. This includes the policies for sanitization, aggregation, and downgrading. The model also defines application-independent properties for entity integrity, referential integrity, and polyinstantiation integrity. <<ETX>>
Effect of Light Intensity, Carbon Dioxide Concentration, and Leaf Temperature on Gas Exchange of Spray Carnation Plants

The rates of CO2 assimilation by potted spray carnation plants (cv. Cerise Royalette) were determined over a wide range of light intensities (45-450 W m~2 PAR), CO2 concentrations (200-3100 vpm), and leaf temperatures (5-35 °C). Assimilation rates varied with these factors in a way similar to the response of single leaves of other temperate crops, although the abso lute values were lower. The optimal temperature for CO 2 assimilation was between 5 and 10 °C at 45 W m~2 PAR but it increased progressively with increasing light intensity and CO2 con centration up to 27 °C at 450 W m -2 PAR and 3100 vpm CO2 as expressed by the equation Topt = —6-47 + 2-336 In C + 0-031957 where C is CO2 concentration in vpm and I is photo synthetically active radiation in W m-2. CO2 enrichment also increased stomatal resistance, especially at high light intensities. The influence of these results on optimalization of temperatures and CO2 concentrations for carnation crops subjected to daily light variation, and the discrepancy between optimal tem peratures for growth and net photosynthesis, are discussed briefly.
Endothelin‐1 production by prostate cancer cell lines is up‐regulated by factors involved in cancer progression and down‐regulated by androgens

Recent data demonstrate that endothelin‐1 (ET‐1) concentration increases in plasma of men with advanced, hormone‐refractory prostate adenocarcinoma. In addition, ET‐1 is involved in osteblastic remodelling and new bone formation, suggesting a role for this vasoactive peptide in the metastatic progression of prostate cancer to the bone.
Genetic Selection for Disease Resistance : Challenges and Opportunities

Animal health and well being have become increasingly important issues for animal producers and consumers. Animal diseases causing morbidity and mortality significantly decrease profitability of animal production. Antibiotics that were once widely used to prevent or treat animal diseases are now administered more judiciously because of consumer fears of residual drugs in meat products and microbial resistance to commonly used antibiotics. Because no new class of antibiotics has been developed in the past three decades, the continued use of antibiotics may become more limited. Also, there has been an emergence of previously unknown diseases such as BSE (Binder et al., 1999) and emergence of infectious diseases in domestic livestock related to climatic changes, more intensive production, and transmission of diseases from wildlife to livestock and vice versa (Daszak et al., 2000). Current fear of a worldwide human influenza pandemic caused by transmission of avian influenza virus to humans has increased public awareness of a need to control animal diseases (Wong and Yuen, 2006). Therapeutic treatment costs for sick animals have continued to increase. Animal well being has become a significant concern among consumers who expect food animals to be well treated, raised in idyllic environments, and free of disease. Consumers also expect their meat products to be free of residual antibiotics and therapeutic drugs.
INVESTIGATING THE RELATIONSHIP BETWEEN QUALITY MANAGEMENT AND ORGANIZATIONAL INNOVATION

One of the benefits of implementing quality management in organizations, establishing an innovation management process in them. According to expert’s expression, quality management and innovation both have great importance to the organization and also have a common goal for meeting customer needs. In recent decade, innovation in enterprises is vital for the survival of organizations, in such a way those organizations have no power of change and alignment with environmental conditions are eliminated from the competition circle. Based on the literature, one of the main factors influencing innovation is the existence and establishment of quality management systems. In this paper, we tried to investigate the relationship between the processes of quality management and innovation in organizations and the results of the most important researches collected and presented. The results of the review of the literature indicate that there is a positive relationship between the quality management system and the organizational innovation.
Differential effects of amitriptyline treatment on testicular and liver functions in adult male rats

3 National Organization for Drug Control and Research (NODCAR), Egypt Abstract:- The aim of our study was to investigate the influence of exposure to amitriptyline treatment with different doses on the activity of liver and testicular indices; and examined these organs histopatholgically to confirm the effect of amitriptyline. This study conducted on 80 adult male rats. The 40 rats were divided into two groups according to received dose of amitriptyline (low & high doses) and the third group (20 rats) received toxic dose of cyclophosphamide to serve as a positive control, beside 20 healthy rats as a control group. After 30 days of treatment, the animals were sacrificed and blood & tissue samples were collected. The results showed that there was no significant difference in rats treated by low dose of amitriptyline as regards liver enzymes (ALT, AST & γGT), testicular functions (testosterone & prolactin levels, and spermatic count) and histopatholgically changes in the tissue of these organs. While the high dose showed significant difference in the liver and testicular functions proved by, the changes occurred in the liver and testicular tissue, which is like the toxic effect of cyclophosphamide. In conclusion, high dose of amitriptyline has toxic effects on the metabolic functions of the liver and reduction in the productive functions of the testis beside the toxic histopathological changes in the tissue of these organs. (New York Science Journal 2010;3(3):10-18). (ISSN: 1554-0200).
Calculation of Starting Performance for Large Two Pole Induction Motors with Comparison to Test Values

Prediction of starting currents and torques in large two pole squirrel cage induction machines (SCIM) is a very complex problem. When values for these parameters are predicted using classical equivalent circuit formulations available in the literature, they do not always agree with test results. These discrepancies may result because of the difficulties associated with estimating the end parameters for the machine, namely the end leakage reactances and end ring resistance. This paper examines the effect of these end parameters on starting calculations made by means of equivalent circuit computations derived from finite element (FE) field solutions. The results indicate that the predictions are very sensitive to values used to estimate these end parameters
The determinants of audit timeliness: Evidence from Malaysia

Timeliness of corporate annual financial reports is considered to be a critical and important factor affecting the usefulness of information that is made available to external users. The length of the audit process highly affects the timeliness of corporate financial reporting as documented by prior literature. The purpose of this study is to examine the determinants of audit report timeliness particularly the effect of audit committee functions in Malaysian audit market. The audit committee is one important component of corporate governance mechanism and they comprise of audit committee size, audit committee qualifications and audit committee meetings. Consequently, the study applied the agency theory and formulated eight hypotheses that guided the analysis. The study sample comprised 491 Malaysian listed companies from Bursa Malaysia, which complied with the regulatory requirements and subjected to supervision of the Central Bank of Malaysia. Regression analysis was performed to examine the audit report timeliness determinants. The results show that audit report lag is influenced by audit committee size, audit committee meetings, auditor type, audit opinion, total assets and firm profitability. However, no evidence was found to support the effects of board independence and audit committee qualifications on audit report timeliness. Apart from contributing to the literature on corporate governance and audit report timeliness, this study also falls under the strand of literature that examines the consequences of regulatory changes. Detail explanations of the findings of the study along with its implications, limitations and future research suggestions are highlighted.
Viability of Lactobacillus casei strain Shirota (LcS) from feces of Thai healthy subjects regularly taking milk product containing LcS.

OBJECTIVE To demonstrate the recovery of Lactobacillus casei strain Shirota (LcS) from feces of Thai subjects who regularly took LcS containing milk product for 1 week and demonstrate the disappearance of LcS after stopped taking milk product. MATERIAL AND METHOD First fecal samples were collected from 20 healthy adults at 10 days after they abstained from all lactobacillus containing milk products. Second specimens taken after the subjects ingested LcS containing milk product for 7 days and third specimens at 7 days after they stopped taking LcS containing milk product. All the fecal specimens were culture for LcS using LLV-FOS culture medium and enumeration of LcS was calculated. All stool samples were also tested for the presence of LcS by using nested PCR to confirm the presence of LcS obtained from culture method. RESULTS Both culture and nested PCR method showed that all the stools samples obtained from subjects prior to the administration of LcS containing milk product were devoid of LcS, except for 3 specimens which showed weakly positive test for PCR. At 7 days after ingesting LcS containing milk product, all stool specimens were positive for LcS on both culture and PCR method. At 7 days after stopped taking LcS containing milk product, 1/19 specimens were positive from culture and 6/ 19 specimens were positive for PCR method. CONCLUSION LcS could survive in the gastrointestinal tract of Thai subjects and could be recovered from the feces after ingestion.
Integrated wideband reflectometer with on-line reference measurement capability

The aim of the paper is to show the novel integrated reflectometer designed for the wideband sensing in the arbitrary frequency band up to 9 GHz and beginning at the DC. The reflectometer utilizes pseudo noise (PN) based single chip transceiver with one transmitter and two wideband sub-sampling receivers including integrated directional couplers. The topology with the two monolithically realized receive channels allows on-line monitoring of the difference between the reference, i.e. well-known medium, and the medium under test (MUT). Simple experiment with moist and dry grain shows the early competence of the approach for the process or material monitoring purposes.
The Structure Characteristic and Productive Attribute Evolution of Beijing Service Industry

The development of service industry is an important indicator of a region’s economic development and service has been the leading industry of Beijing. But, does the service industry play a supporting role in the production of the whole economy? This paper analyzes Beijing’s service industry, including its structure characteristics, productive attribute, service input structure, the demand for productive service, and the evolution over the past ten years. The results show that: (1) the industry structure of Beijing presents advanced features compared with developed countries, not only in structure of the three industrial, but also in structure of the service internal sectors; (2) the productive service attribute of Beijing service industry declined, among which the information service industry declined the most; as to the input structure of productive service, the share of the second industry decreased, which reflects the support on the secondary industry decreased; from the perspective of demand for producer service, the productive service demand ratio of Beijing economy as a whole decreased, and the decline demand of the secondary industry is the main reason.
How logistics & supply chain can create and appropriate customer value

Cost reduction in itself cannot be the goal for an organization; the real source for the organization’s existence is to create customer value. It is therefore crucial that logistics and supply chain professionals not focus on efficiency but also contribute to value creation and, thereby, to the firm’s competitiveness. To gain a better understanding of customer value, a customer value matrix is introduced based on two leading concepts. Firstly, the value as perceived by the customer, which is the difference between the perceived (tangible and intangible) benefits and the perceived sacrifice. Secondly, the customer perceived value has three distinct temporal positions, namely pre-purchase, transaction and post-purchase. For demonstrating how (net) total value can be created, a model with three supply entities (customer, firm, and suppliers) is discussed. This model is used to demonstrate that in essence there are five ways to create (net) total value. Furthermore, it is argued that value creation (VC) and value appropriation (VA) should always go hand in hand. Three forms for VA are reviewed, namely value pricing, relationship building and learning. From the analysis, three conclusions for logistics and supply chain professionals are derived. Firstly, the view of customer value must be extended far beyond the traditional transactional dimensions. Secondly, an in-depth knowledge of the entire customer journey is imperative. This requires close cooperation with Marketing & Sales colleagues and frequent contacts with customers. Thirdly, the concepts of customer value, the firm’s shareholder value, employee value and supplier value are all related and collectively they constitute the net total value created. Engagement of the four stakeholders is the key enabler of VC as well as VA. For this reason collaboration with all the stakeholders like employees, suppliers, customers and shareholders is paramount.
Impact of human resource accounting system on the decisions making areas of human resource management practices

Success of an organization depends on the quality of human resources. Human resource plays the vital role in the development of an enterprise. Human resource accounting measure the value of employees which helps the management in taking important decisions related to human resource management practices so as to improve the efficiency and productivity of an enterprise. Thus the present study examines the impact of human resource accounting system on the decision making areas of human resource management practices. For the purpose of the study data were collected among the 100 respondents from the Head office of State Bank of India and Canara bank in the Kerala region targeted at the staff of human resource department, accounting section and audit control department. Hence the collected data were analyzed using Correlation analysis and Multiple Regression analysis model validated through ANOVA and F Ratio. The study found that all the aspects related to the implementation of Human Resource Accounting is closely associated and has 67.1 percent impact on the decision making areas of human resource management practices.
Detection of an RNA-dependent RNA polymerase in mitochondria from a mitovirus-infected isolate of the Dutch Elm disease fungus, Ophiostoma novo-ulmi.

RNA-dependent RNA polymerase (RdRp) activity has been detected in mitochondria from an isolate of Ophiostoma novo-ulmi infected with O. novo-ulmi mitovirus 6 (OnuMV6). The reaction products corresponded to the double-stranded and single-stranded forms of OnuMV6 RNA. Western blot analysis using antibodies raised against a conserved RdRp region has detected a protein of ca. 80 kDa in OnuMV6-infected mitochondria, close to the predicted size of the OnuMV6 RdRp. No RdRp activity or protein was detected in mitochondria from an uninfected O. novo-ulmi isolate. This is the first detection of a virus RdRp in fungal mitochondria and the results are consistent with the use of UGA tryptophan codons in its synthesis.
Evaluation of Changes in Bone Height And Bony Union In Free Fibula Flap for Microvascular Reconstruction of Mandible

Objective: This study was done to evaluate the changes in vascularised free fibula graft for mandible reconstruction with respect to height of fibula graft and bony union at the ends of graft and osteotomy sites. Methods: A follow up study was conduted with 5 cases of mandibular resection due to aggressive benign tumor and reconstruction with vascularised free fibula flap. Changes in bone height were measured over time using serial panorex evaluation with respect to anatomic site of reconstruction immediate after surgery, after 3 , 6, 9 and 18 months postoperatively. Measurements were taken with vernier caliper in subsequent panorex examinations. Results: Radiographic aanalysis showed bony of union of the graft ends and at the osteotonmy sites in 4 cases. One patient who had post operative infection bony union was not definite.The height of fibula for the central segment was initially 18 mm and it decreased to 14.28 percent of the initial height (mean 2.4 mm) after 12 months. The height of body part ranged from 14mm to 19 mm initially and decreased to 5.35 percent of initial height (mean 0.75 mm). For the mandibular ramal segment , the height ranged from 11mm to 12 mm initially, and it decreased to 13 percent of the initial height ( mean 1.5 mm). The analysis revealed a monthly atrophy of the fibula bone of about 0.12 mm. Conclusion : The vascularised free fibula flap is a durable method of osseous mandibular reconstruction.