Miracle-dz/UniFAR-FTUs huggingface dataset:
Chromosomal alterations of pediatric malignancy in a West Texas population

Background: Comparative genomic hybridization (CGH) microarrays are used for genome-wide evaluation of copy number variations (CNV) of known prognostic significance; however, unannotated variants of uncertain significance (VUS) are frequently present. To identify potentially actionable targets, we retrospectively analyzed VUS loci using CGH data from 192 cases of cancer or genetic disorders treated at TTUHSC. Methods: DNA was hybridized onto CytoSure Constitution V3 arrays, scanned with the Agilent microarray D scanner, and analyzed by CytoSure Interpret Software. Results: We found 794 distinct CNVs, the most frequent being 14q32.22 (112 rearrangements), 14q11.2 (100), 8p11.2 (98), 15q11.1-q11.2 (83), and 8p23.1 (77). In particular, 8p11.22 alterations were found in many pediatric tumors, with gain/loss ratio of 4.7. Linkage of TACC1, TM2D2, KAT6A and ADAM32 was indicated by a similar 5-year survival rate of 75.3% (n = 253), which was greater than in unaltered cases (62.2%, n = 15,809 cases) in The Cancer Genome Atlas database. Conclusion: Knockdown of genes occurring at variants of uncertain significance (VUS) loci may help identify new therapy targets.
Perceived school goal structure, achievement goals and emotions in teaching of Singapore teachers

ABSTRACT This study investigated the mediational relationship between teachers’ perceived school goal structure, achievement goals and emotions in teaching. The participants were 495 Singapore teachers who took an online survey on the measured variables. We conducted structural equation modelling to test the hypothesized mediation model and found that teachers’ achievement goals partially mediated the relationship between teachers’ perceived school goal structure and emotions in teaching. More specifically, teachers’ perceived school learning goal structure was associated positively with their mastery goals and performance-approach goals. Via mastery goals, teachers’ perceived school learning goal structure was associated positively with enjoyment, and negatively with anger and anxiety in teaching. In addition, teachers’ perceived school learning goal structure was also directly associated with teacher enjoyment positively and teacher anger negatively. Teachers’ perceived school performance goal structure was associated positively with their performance-approach and performance-avoidance goals, and it was associated positively with teacher anxiety via the mediation of performance-avoidance goals. Theoretical and practical implications of the findings are discussed.
Comprehensive Survey of Key Technologies Enabling 5G-IoT

5G technology targets to address the limitations of previous cellular standards and a potential key enabler for future IoT. This paper presents a comprehensive survey of the enabling technologies for 5G IoT. While there has been a consensus in the overall requirements of 5G wireless systems (eg data rate, network capacity, delay etc.) various enabling technologies have been considered and studied to achieve these performance targets. Some of these wireless technologies like massive input massive output (MIMO), heterogeneous networks (HetNets), device-to-device (D2D) communication has already become the focus of global industry. These technologies enable the 5G system to achieve improved data rate, increased capacity, decreased latency and enhanced spectral efficiency. This paper aimed at describing them and discussing their potentials.
Minimally invasive plate osteosynthesis on treatment of tibia fractures in dogs

Özet: Bu klinik çalı~mada, minimal invaziv plak osteosentezinin, köpeklerde diafizer tibia kırıklarında uygulanabilirliğinin belirlenmesi, sağaitım sonuçlarının klinik ve radyolojik değerlendirilmesi amaçlandı. Çalı~ına materyalini. Ankara Üniversitesi Veteriner Fakiiltesi Ortopedi ve Travmatoloji Bilim Dalı Kliniği'ne 1999-2001 yılları arasında, trafik kazası sonrası getirilen, klinik ve ı'adyolojik muayeneler sonrasında farklı tibia kırıkları belirlenen deği~ik ırk, ya~ ve cinsiyette 8 köpek olu~turdu. Belirlcnen tibia kırıklarının, 6, 8 veya iO delikli 3.5'luk dinamik kompresyon plakları (DCP) ve minimal invaziv plak uygulaması ile fiksasyonu sağlandı. Kırık hattının rediiksiyomı ve ensizyon hatlarından plağın her iki ucundaki vida deliklerine 2 veya 3 kortikal vida yerleştirilmesi sonrasında ensizyonlar bilinen yöntemlerle kapatıldı. Klinik ve radyolojik muayenelerle diizenli olarak izlenen köpeklerde, radyolojik muayeneler sonrasında, bazı hayvanlarda kırık fragmanlarının tam rediiksiyonunda kısmi kayıplar söz konusuyken. kırık iyile~mesinin hızlı geliştiği, operasyon süresinin geleneksel plak uygulama yöntemlerine göre kısaldığı belirlendi. Ayrıca. parçalı olmayan diafizer tibia kırıklarında da tekniğin fonksiyonel bir uygulama olduğu gözlendi. Plaklar posıoperatif 9. veya iO.haftalarda alındı ve herhangi bir komplikasyon gelişimi izlenmedi. Anahtar kelimeler: Köpck, minimal invaziv plak fiksasyonu, tibia kırığı
Optimal Inventory Control Strategies for Deteriorating Items with a General Time-Varying Demand under Carbon Emission Regulations

Climate warming nowadays has caused people to increasingly enhance public awareness about carbon emissions from industries. In the storing industry, inventory management for deteriorating items is crucial in the business competition. To slow down the deterioration and ensure the quality of products, the items are usually stored in certain temperature-controlled environment. However, a lot of carbon emissions of the inventory system are caused by these warehousing activities. In a finite panning period, this paper studies a continuous review inventory system and proposes inventory models to analyze the impacts of carbon emissions on inventory system for deteriorating items with a general time-varying demand, in which shortages are allowed, and the customer demand during shortage period is partially backlogged till the next replenishment. Under carbon emission regulations, the existence and uniqueness of the optimal solution to each model is explored and comparisons of optimality among the proposed models are given. Numerical examples and robust analysis of the models are presented to illustrate the applicability in practice. Some management insights about inventory policies and emission reduction strategies are obtained.
Effect of Market Orientation on Organizational Performance (A Study of the Nigerian Banking Industry)

This study examined the relationship between market orientation culture and organization performance among banks in Nigeria. Two hundred and twenty copies of questionnaire were distributed to staff of nine banks. Cross sectional research design was adopted. The population of the study comprises of 500 staff of selected Banks, and a total of 220 staff was sampled. Data were collected and analyzed using 210 retrieved sets questionnaire. Correlation and multiple regression analysis was conducted. The study established that there is a significant positive relationship between market oriented culture (customer orientation, competitor orientation and inter-functional coordination) and their effect on organizational performance in the Nigerian banking sector.The study also developed an enhanced model that combines the resource-based view of the firm theory and the dynamic capability theory to explain the organizational culture and market orientation culture of bank institutions in Nigeria as key determinants of bank performance. It is recommended that banks should consider customer needs in developing their corporate strategy.
Factors Affecting Transmission Mode Evolution in Symbioses

FACTORS AFFECTING TRANSMISSION MODE EVOLUTION IN SYMBIOSES Alexandra Brown Erol Akçay Symbiosis, where organisms of different species live closely together, is ubiquitous in our world. It is thought that all multicellular organisms engage in symbiosis, in relationships where the symbiont’s effect on the host ranges from beneficial (mutualism) to neutral (commensalism) to harmful (parasitism), and can even switch between mutualism and parasitism, depending on environmental conditions (conditional mutualism). Symbiosis can also have a large, though generally beneficial, impact on the symbiont’s fitness, and can further affect third parties who interact with the host or symbiont. The manner in which symbionts are transmitted between hosts can affect not only the distribution of symbionts (and hosts) but also selection on the costs and benefits of the interaction. For example, symbionts are that are transmitted from parent to offspring (vertical transmission) are predicted to evolve to benefit their hosts, while symbionts that are transmittted between unrelated individuals (horizontal transmission) are predicted to evolve intermediate virulence that maximizes their ability to infect new hosts. Understanding transmission evolution is thus important to predicting the ultimate fate of symbioses. I investigate three aspects of transmission evolution. First, since transmission evolution is known to depend on whether it is under host or symbiont control, I used phylogenetic methods to estimate control of
Influence of Substrate Bias Voltage on Structure, Morphology and Mechanical Properties of AlCrN Coatings Synthesized Using Cathodic Arc Evaporation

AlCrN is one of the most widely studied hard coatings, especially if it is about their thermal resistance and mechanical properties. However, adhesion and wear resistance of AlCrN coatings synthesized from an Al-rich AlCr (80:20) cathode has not been studied yet. The influence of substrate bias voltage on the properties of coatings formed by cathodic arc evaporation was investigated. The morphology, phase and chemical composition, hardness, adhesion as well as wear of the coatings were analyzed by XRD, EDX, SEM, nanoindenter, scratch and ball-on-disc testers. It was found that as the negative substrate bias voltage (UB) increased, the rate of deposition and the macroparticle number on the surface of the coating decreased, mainly due to the resputtering phenomenon. X-ray diffraction showed that the intensity of h-AlN diffraction lines decreases and the intensity of the cubic CrN diffraction lines increases with the increase of the negative substrate bias voltage. The hardness of the coatings increases and critical load Lc2 decreases with negative substrate bias voltage. The lowest wear rate, about 1.1×10-16 m3/Nm, was observed for coating deposited at
The ‘Fuck White People’ Phenomenon in South Africa: A Discursive and Statistical Analysis

ABSTRACT During the recent student protests in South Africa ‘fuck white people’ appeared on T-shirts and walls. When understood only as anti-white sentiments, these words could cause panic and fear. However, we need to determine the extent to which these opinions are shared, by whom, and what should be done to people who propagated these views. To address these questions, an item was inserted in the 2016 nationally representative South African Social Attitudes Survey (n = 2988). An overwhelming majority of the adult population (96%) expressed a clear preference for how this phenomenon should be addressed. Of this, 26% recommended that those wearing/writing this phrase should be informed that they are hampering the prospects of peaceful coexistence between different race groups (the social cohesion argument), while 39% advocated refrain from such rhetoric. 16% adopted a retributive stance and little more than a tenth (13%) non-interventionist. Only a nominal proportion (2%) believed such behaviour ‘should be praised’ for drawing attention to persisting white privilege in South African society. We discuss these findings and their socio-demographic variations discursively, as part of ‘white fragility’ and ‘rainbow nation mythology’, observing the provocative and productive dimensions of this phenomenon.
AB0550 Hughes-Stovin Syndrome: Successful Use of Infliximab in Life Threatening Behcet's, with Pulmonary Involvement in 3 Cases in An University Hospital

Background Hughes-Stovin Syndrome (HSS) is described as a very rare vascular manifestation of Behcet's disease in medical literature. HSS is a very rare clinical disorder and around 40–60 published cases of HSS have been described in medical literature so far. Objectives To illustrate the use of Infliximab in three cases. Methods Case1: A 25 year old male presented with optic nerve emboli, oral ulcers and CT scan revealed pulmonary artery aneurysms within the right lower lobe and pulmonary emboli (image). This was treated with Endovascular coiling, pulsed cyclophosphamide, mycophenolate and prednisolone. He had ongoing episodes of haemoptysis that were treated with Infliximab. The patient is now well controlled on Infliximab, mycophenolate and prednisolone. Case2: A 34 year old male with history of genital and mouth ulcers, presented with haemoptysis and CT scan showed multiple pulmonary emboli with aneurysms. He was treated with pulsed Methyl-prednisolone and infliximab 5mg /kg at weeks 0,4,6 and 8, followed by every 8 weeks and Methotrexate. He later developed a DVT, therefore the methotrexate was switched to Azathioprine 2.5mg/kg/day and he received Methyl-prednisolone. Infliximab dose was increased to every 2 weeks. After ongoing review he was switched from Infliximab to Adalimumab and he is now in remission. Case3: A 19 year old male admitted with haemoptysis and respiratory compromise and was intubated in ICU. His CTPA showed bilateral pulmonary emboli with aneurysms. He had erythematous macules, follicular papules, oral ulcers and weight loss with positive pathergy. He was treated with IV methyl prednisolone and infliximab 5mg/kg every 2 weeks.He was extubated 24 hrs after starting treatment and he was discharged home within 9 days of treatment.He is maintained on Adalimumab and Azathioprine and he is now in remission. Results Although case 1 did not fulfill the ISG criteria for Behcet's disease, case 2&3 fulfilled the criteria. Case1 had a protracted course although managed as per Behcet's pathway by Behcet's centres of excellence in UK and Infliximab was used as a step up treatment. Case 3 presented very unwell, but he was extubated 24 hrs after starting treatment and Infliximab was used as an induction treatment. Conclusions Early diagnosis and timely intervention is crucial in improving the prognosis of patients with HSS. Our experience of these 3 rare cases suggests that Infliximab should be used as induction treatment in managing life threatening HSS. References Orphanet J Rare Dis. 2011 Apr 13;6:15. doi: 10.1186/1750-1172-6-15. Review.Hughes-Stovin syndrome. Khalid U, Saleem T. Oman Med J. 2015 Jan;30(1):59–62. doi: 10.5001/omj.2015. 11.Hughes-stovin syndrome and massive hemoptysis: a management challenge.Al-Zeedy K, Jayakrishnan B, Rizavi D, Alkaabi J Clin Pract. 2014 Nov 6;4(3):647. doi: 10.4081/cp.2014. 647. eCollection 2014 Oct 30. Moderate hemoptysis caused by hughes-stovin syndrome. El Aoud S, Frikha F, Snoussi M, Bahloul Z. Disclosure of Interest None declared
The role of HRS phosphorylation in endosomal trafficking and signalling.

Hepatocyte growth factor receptor substrate (HRS) is a component of the ESCRT-0 complex. It is involved in the sorting of ubiquitylated receptors into the lumen of multivesicular bodies (MVBs), thus targeting them for lysosomal degradation. HRS is highly phosphorylated in response to stimulation by various growth factors, but despite this, the functional role of its phosphorylation is still contentious. Preliminary data from our laboratory suggested that HRS may also act as a signalling adaptor, involved in the crosstalk between receptor tyrosine kinases (RTKs) and G protein couple receptors (GPCRs). In order to investigate this hypothesis, I first examined the EGF dependent interactors of HRS by mass spectrometry. I then developed tools for the measurement of endosomal cAMP production and PKA signalling. My data suggests that HRS interacts with the E3 ligase deltex3-like (DTX3L) in an EGF dependent manner. Although an association between these proteins has previously been made, its EGF dependence is novel. DTX3L has previously been shown to modulate the recruitment of HRS to endosomes in response to stimulation of the G-protein coupled receptor CXCR4. This new finding offers a theoretical means through which different receptor classes could crosstalk and elicit an integrated signalling response. I further show that GFP-HRS is recruited directly to newly formed vesicles containing EGF and its receptor. Recruitment of HRS to endosomes/vesicles in response to TGFα, but not EGF, is partly dependent on phospho-tyrosine residues Y329 and Y334. Furthermore, HRS has recently been implicated in the recruitment of the recycling complex WASH to endosomes. This, combined with the previous observation, suggests that phosphorylation of these two sites may be involved in receptor recycling. Overall, my thesis generates new tools for the study of HRS function and for the analysis of endosomal signalling. I provide evidence for the role of HRS in RTK and GPCR crosstalk alongside providing insights into the mechanisms governing recruitment of HRS.
Fixed point under set-valued relation-theoretic nonlinear contractions and application

We establish a relation theoretic version of the main result of Aydi et al. [H. Aydi, M. Abbas, C. Vetro, Partial Hausdorff metric and Nadler? s fixed point theorem on partial metric space, Topol. Appl. (159), 2012, 3234-3242] and extend the results of Alam and Imdad [A. Alam, M. Imdad, Relation-theoretic contraction priciple, J. Fixed Point Theory Appl. , 17(4), 2015, 693-702. ] for a set-valued map in a partial Pompeiu-Hausdorff metric space. Numerical examples are presented to validate the theoretical finding and to demonstrate that our results generalize, improve and extend the recent results in different spaces equipped with binary relations to their set-valued variant exploiting weaker conditions. Our results provide a new answer, in the setting of relation theoretic contractions, to the open question posed by Rhoades on continuity at fixed point. We also show that, under the assumption of k-continuity, the solution to the Rhoades? problem given by Bisht and Rakocevic characterizes completeness of the metric space. As an application of our main result, we solve an integral inclusion of Fredholm type.
From Charge to Spin and Spin to Charge: Stochastic Magnets for Probabilistic Switching

As the rapid pace of Moore’s Law has been slowing down, there has been intense activity to “reinvent the transistor. ” An emerging paradigm is to complement the existing complementary metal-oxide–semiconductor (CMOS) technology with new functionalities, rather than finding a drop-in replacement for it. In this article, we discuss such a complementary approach that we call probabilistic spin logic (PSL) based on the concept of a probabilistic or p-bit. p-bits fluctuate between 0 and 1 and can be imagined in between deterministic bits that are either 0 or 1 and quantum bits that are a superposition of 0 and 1. Interconnected circuits built out of p-bits (p-circuits) can be broadly useful for machine learning and quantum computing in the solution of problems that conventional CMOS may not be particularly suited for. Although such p-bits can be implemented using standard CMOS technology, we will show that the inherent physics of nanomagnets can naturally provide an energy efficient and scalable p-bit implementation through the use of low-barrier magnetic tunnel junctions (MTJs). In this article, we provide a general description of p-bits and p-circuits and discuss their applications. We review experimental progress toward constructing p-bits and p-circuits exploiting the inherent stochasticity of nanomagnets, from a physics/device/circuits perspective. In particular, we identify building blocks for “write” and “read” operations that can be used in different combinations to construct functional p-bits and p-circuits. Finally, we discuss the prospects and challenges of PSL as an emerging, unconventional computing paradigm for a beyond CMOS era.
A global climatology of the ocean surface during the Last Glacial Maximum mapped on a regular grid (GLOMAP)

Abstract. We present a climatology of the near-sea-surface temperature (NSST) anomaly and the sea-ice extent during the Last Glacial Maximum (LGM, 23 000–19 000 years before present) mapped on a global regular 1∘×1∘ grid. It is an extension of the Glacial Atlantic Ocean Mapping (GLAMAP) reconstruction of the Atlantic NSST based on the faunal and floral assemblage data of the Multiproxy Approach for the Reconstruction of the Glacial Ocean Surface (MARGO) project and several recent estimates of the LGM sea-ice extent. Such a gridded climatology is highly useful for the visualization of the LGM climate, calculation of global and regional NSST averages, and estimation of the equilibrium climate sensitivity, as well as a boundary condition for atmospheric general circulation models. The gridding of the sparse NSST reconstruction was done in an optimal way using the Data-Interpolating Variational Analysis (DIVA) software, which takes into account the uncertainty in the reconstruction and includes the calculation of an error field. The resulting Glacial Ocean Map (GLOMAP) confirms the previous findings by the MARGO project regarding longitudinal and meridional NSST differences that were greater than today in all oceans. Taken at face value, the estimated global and tropical cooling would imply an equilibrium climate sensitivity at the lower end of the currently accepted range. However, because of anticipated changes in the seasonality and thermal structure of the upper ocean during the LGM as well as uneven spatial sampling, the estimated cooling and implied climate sensitivity are likely to be biased towards lower values.
Toxic Expectations: Analyst Forecasts and Firm Pollution

Firm pollution can reduce firm earnings as a result of regulatory costs or reduced consumer demand; effective security research should consider such private costs when predicting the profitability of polluters. However, due to anti-polluter sentiment, investor environmental, social, and governance (ESG) preferences, and security analyst behavioral biases, I hypothesize that analysts may consistently overestimate the private costs of pollution and subsequently undershoot in their earnings forecasts for polluters. Consistently, this study finds evidence of systematic pessimism in analyst forecasts for polluting firms, a one standard deviation increase in emissions is associated with a 1.3% increase in forecast error. This polluter pessimism is stable in magnitude from 1987 to 2017. Furthermore, this research shows that biases toward polluters are sticky, consistent with the conservatism bias. Analysts who are ex ante biased toward polluters continue to hold those biases ex post, even after recent earnings announcements prove them wrong.
Visible Light Communication and Augmented Reality for Underground Positioning System

Visible Light Communication (VLC) technology allows wireless data transmission piggybacked by illumination. Highly accurate and reliable systems based on VLC, as Indoor Positioning System (IPS) have been already developed by academics and specialized companies. Underground Positioning System (UPS) addressed here is embedded into the protection equipment, compulsory to be used underground, being therefore important to workers in potential dangerous spaces since fast data communication and real-time data interpretation is therefore possible. This paper presents the VLC technology implemented in mining underground specific environment for an accurate positioning and fast data communication for underground navigation with the main aim of developing a real time warning and alarming system based on Augmented Reality (AR) and Neural Networks (NNs) principles.