Miracle-dz/UniFAR-FTUs huggingface dataset:
Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane

Caragelasco D.S. , Kogika M.M. , Martorelli C.R. , Kanayama K.K. & Simões D. M.N. 2017. Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane. Pesquisa Veterinária Brasileira 37(7):734-740. Departamento de Clinica Médica, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, São Paulo, SP 05508-270, Brazil. E-mail: mv.douglas@usp.br Hyperadrenocorticism is one of the most common endocrine disorders in dogs. Regarding to the kidneys, chronic hypercortisolemia can cause damage to the glomerulus, and evolve into chronic kidney disease. This study evaluated nine normotensive dogs with pituitary dependent hyperadrenocorticism, before and after therapy with trilostane, during the follow-up period of six months, in order to investigate the development of pathological proteinuria by quantitative (urinary protein-to-creatinine ratio) and qualitative (urinary protein electrophoresis) methods, and also to monitor its intensity over the course of the disease and therapy. The main renal lesion detected in dogs with hyperadrenocorticism was in the tubular segment, evidenced by the prevalence of urinary protein bands of lower molecular weight, indicating the lack absorption of these proteins in the proximal segment of the nephron. Low molecular weight proteins persisted throughout the follow-up. Regarding the future of routine veterinary medical clinic in the care of patients with hyperadrenocorticism, the assessments of proteinuria determinations by the urinary protein-to-creatinin ratio and urinary protein electrophoresis, according to the results obtained in this study, can add more information about the renal damage in these animals, and contribute to the prognosis.
Quantitation of single action potential-evoked Ca2+ signals in CA1 pyramidal neuron presynaptic terminals

Presynaptic Ca2+ evokes exocytosis, endocytosis, and short-term synaptic plasticity. However, Ca2+ flux and interactions at presynaptic molecular targets are difficult to determine, because imaging has limited resolution. We measured single varicosity presynaptic Ca2+ using Ca2+ dyes as buffers, and constructed models of Ca2+ dispersal. Action potentials evoked Ca2+ transients (peak amplitude, 789±39 nM, within 2 ms of stimulation; decay times, 119±10 ms) with little variation when measured with low-affinity dye. Endogenous Ca2+ buffering capacities, action potential-evoked free [Ca2+]¡ and total amounts entering terminals were determined using high-affinity Ca2+ dyes to buffer Ca2+ transients. These data constrained Monte Carlo (MCell) simulations of Ca2+ entry, buffering, and removal. Data were well-fit with simulations of experimentally-determined Ca2+ fluxes, buffered by simulated Calbindin28K. Simulations were consistent with clustered Ca2+ entry followed within 2 ms by diffusion throughout the varicosity. Repetitive stimulation caused free varicosity Ca2+ to sum. However, simulated in nanometer domains, its removal by pumps and buffering was negligible, while diffusion rates were high. Thus, Ca2+ within tens of nanometers of entry, did not accumulate during sequential stimuli. A model of synaptotagmin1-Ca2+ binding indicates that even with 10 μM free varicosity Ca2+, synaptogmin1 must be within tens of nanometers of channels to ensure occupation of all its Ca2+ binding sites. Repetitive stimulation, which evokes short-term synaptic enhancement, does not modify probabilities of Ca2+ fully occupying synaptotagmin1’s C2 domains, suggesting that enhancement is not mediated by Ca2+-synaptotagmin1. We conclude that at spatio-temporal scale of fusion machines, Ca2+ necessary for their activation is diffusion dominated.
Suppressive effect of prohydrojasmon on western flower thrips Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae) on greenhouse tomato plants

Abstract The western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae) is an important pest that transmits tospoviruses such as Tomato spotted wilt virus. Jasmonate (JA) and its derivatives are phytohormones with essential roles in plant defense against herbivorous arthropods. In experiments conducted over 2 years, we evaluated how spraying with prohydrojasmon (PDJ), a JA derivative, affected F. occidentalis infestations of greenhouse-grown tomato plants. Single or consecutive sprayings of 400 nmol/mL PDJ in the early plant growth stage significantly suppressed thrips infestation and feeding damage as well as spinetoram. Although spraying with PDJ slightly inhibited initial plant growth, fruit yields and quality were not affected. These results suggest that PDJ could be practically used as a repellent to control F. occidentalis infestation and primary tospovirus infection in commercial tomato greenhouses.
The Hercules beetles (subgenus Dynastes, genus Dynastes, Dynastidae): a revisionary study based on the integration of molecular, morphological, ecological, and geographic analyses

The taxonomic treatment of Hercules beetles (subgenus Dynastes of the genus Dynastes MacLeay, 1819) is revised, with the recognition of two major species groups and 15 species. The following 10 taxa, originally designated as subspecies, have been elevated to full species status: Dynastes moroni Nagai, 2005 (REVISED STATUS); Dynastes bleuzeni Silvestre and Dechambre, 1995 (NEW STATUS); Dynastes ecuatorianus Ohaus, 1913 (NEW STATUS); Dynastes lichyi Lachaume, 1985 (NEW STATUS); Dynastes morishimai Nagai, 2002 (NEW STATUS); Dynastes occidentalis Lachaume, 1985 (NEW STATUS); Dynastes paschoali Grossi and Arnaud, 1993 (NEW STATUS); Dynastes reidi Chalumeau, 1977 (NEW STATUS); Dynastes septentrionalis Lachaume, 1985 (NEW STATUS); and Dynastes trinidadensis Chalumeau and Reid, 1995 (NEW STATUS). The use of the species name Dynastes hercules (Linnaeus, 1758) is restricted to only two island populations from Guadeloupe and Dominica. This taxonomic revision is accompanied by discussions of the basis for these taxonomic changes, i.e. based on differences in genetic, phenotypic, and ecological data and on estimates of geographic overlap. An updated Dynastes beetle phylogeny based on Illumina sequencing data is also presented for a discussion of the evolutionary relationships among the species. 1Museum of Zoology, University of Michigan, Ann Arbor, MI 48109, USA Misc. Publ. Mus. Zool. , univ. Mich. , no. 206 2
Impact du stress oxydant sur l'intégrité de l'épigénome spermatique murin

Chez les Mammiferes, le succes de la fecondation et d’un developpement embryonnaire viable resident principalement dans la qualite des cellules reproductrices : les gametes mâles (spermatozoides) et femelles (ovocytes) apportant chacun la moitie du patrimoine genetique du futur individu. Des lors que ce patrimoine genetique est endommage par differents processus tels que les attaques radicalaires communement appelees stress oxydant, cela peut compromettre la qualite des gametes et par consequent le succes de la reproduction. En effet, les dommages oxydants a l’ADN spermatique sont une des causes d’infertilite masculine frequemment associes aux echecs reproductifs dans le cadre de conception naturelle ou artificielle chez l’homme. Afin de mieux apprehender l’impact des dommages oxydants sur la qualite des spermatozoides, notre equipe a genere des modeles murins presentant des atteintes oxydantes de l’ADN associees a des echecs reproductifs. Dans un de ces modeles nous avons pu montrer que tout le noyau spermatique n’etait pas concerne de la meme facon par les alterations oxydantes. De meme, a l’echelle des chromosomes murins les investigations de l’equipe suggeraient que tous n’etaient concernes de la meme facon. Dans ce travail de these, j’ai developpe et mis en œuvre des protocoles d’hybridation in situ en fluorescence (FISH) permettant de montrer que la susceptibilite des chromosomes a l’oxydation est determinee par la position des chromosomes dans le noyau spermatique murin. En parallele de cette etude, je me suis interesse a l’epigenome spermatique et plus particulierement a la methylation de l’ADN en conditions de stress oxydant. Les resultats preliminaires montrent qu’un environnement post-testiculaire pro-oxydant peut alterer le profil epigenetique spermatique. Dans un developpement pre-clinique du sujet, j’ai contribue a montrer qu’une supplementation orale antioxydante permettait de corriger les dommages oxydants a l’ADN, en modifiant la reponse antioxydante globale du tissu epididymaire des animaux.
Improved the C–V Curve Shift, Trap State Responsiveness, and Dynamic RON of SBDs by the Composite 2-D–3-D Channel Heterostructure Under the OFF-State Stress

In this article, the <inline-formula> <tex-math notation="LaTeX">${C}$ </tex-math></inline-formula>–<inline-formula> <tex-math notation="LaTeX">${V}$ </tex-math></inline-formula> curve shift, trap densities responsiveness, and dynamic <inline-formula> <tex-math notation="LaTeX">${R}_{ON}$ </tex-math></inline-formula> of AlGaN/GaN/GaN:C (SH:C) and AlGaN/GaN/graded-AlGaN:Si/GaN:C (DH:Si/C) heterostructure Schottky barrier diodes (SBDs) have been systematically analyzed. Due to additional 3-D electrons in graded-AlGaN:Si layer, the composite 2-D–3-D channel of DH:Si/C has a higher carrier concentration. Reducing the OFF-state electric field strength through AlGaN:Si insert layer, a smaller positive shift of <inline-formula> <tex-math notation="LaTeX">${C}$ </tex-math></inline-formula>–<inline-formula> <tex-math notation="LaTeX">${V}$ </tex-math></inline-formula> curve is achieved under OFF-state stress. Due to the charge shielding effect of AlGaN:Si insert layer, trapping/detrapping effects in GaN:C buffer under the OFF-state stress are well suppressed. Compared with SH:C heterostructure, the trap density responsiveness of DH:Si/C heterostructure under OFF-state stress is significantly reduced. At the same time, trap density responsiveness of the upper channel is immune to OFF-state electric stress time. In addition, the proposed SBDs show lower ON-resistance with on reverse bias stress and better dynamic performance with on reverse stress time.
Diag2graph: Representing Deep Learning Diagrams In Research Papers As Knowledge Graphs

Which are the segmentation algorithms proposed during 2018-2019 in CVPR that have CNN architecture? ’ Answering this question involves identifying and analyzing the deep learning architecture diagrams from several research papers. Retrieving such information poses significant challenge as most of the existing academic search engines are primarily based on only the text content. In this paper, we introduce Diag2Graph, an end-to-end framework for parsing deep learning diagram-figures, that enables powerful search and retrieval of architectural details in research papers. Our proposed approach automatically localizes figures from research papers, classifies them, and analyses the content of the diagram-figures. The key steps in analyzing the Figure content is the extraction of the different components data and finding their structural relation. Finally, the extracted components and their relations are represented in the form of a deep knowledge graph. A thorough evaluation on a real-word annotated dataset has been done to demonstrate the efficacy of our approach.
The Mesoproterozoic Stac Fada Member, NW Scotland: an impact origin confirmed but refined

The origin of the Stac Fada Member has been debated for decades with several early hypotheses being proposed, but all invoking some connection to volcanic activity. In 2008, the discovery of shocked quartz led to the hypothesis that the Stac Fada Member represents part the continuous ejecta blanket of a meteorite impact crater, the location of which was, and remains, unknown. In this paper, we confirm the presence of shock-metamorphosed and -melted material in the Stac Fada Member; however, we also show that its properties are unlike any other confirmed and well documented proximal impact ejecta deposits on Earth. Instead, the properties of the Stac Fada Member are most similar to the Onaping Formation of the Sudbury impact structure (Canada) and impact melt-bearing breccias from the Chicxulub impact structure (Mexico). We thus propose that, like the Sudbury and Chicxulub deposits, Melt Fuel Coolant Interactions – akin to what occur during phreatomagmatic volcanic eruptions – played a fundamental role in the origin of the Stac Fada Member. We conclude that these rocks are not primary impact ejecta but instead were deposited beyond the extent of the continuous ejecta blanket as high-energy ground-hugging sediment gravity flows.
Surface Decontamination of Fresh, Whole Peaches (Prunus persica) Using Sodium Hypochlorite or Acidified Electrolyzed Water Solutions

ABSTRACT Nearly half (45%) of the U.S. peach production is sold through the fresh market sector, making post-harvest disinfectant washing treatments a critical step for reducing surface microorganisms. This study was conducted to determine the effects of various disinfectant washing treatments on the surface decontamination of fresh whole freestone peaches. Minimal application of disinfectant washing treatments (five-second dip) reduced numbers of Listeria innocua recovered from inoculated peaches by 93% (acidified electrolyzed water containing 22 ppm sodium hypochlorite, pH 2.8) or 96% (chlorine containing 22 ppm sodium hypochlorite, pH 8.2) compared to cell counts on unwashed or water-only washed peaches. Increasing the wash time to 40 minutes resulted in a greater reduction in numbers of Listeria innocua recovered from the surfaces of peaches (99.95% and 99.9% for acidified electrolyzed water and chlorine treatments, respectively). All of the washing treatments decreased counts of total aerobic microorganisms on peaches (>92% reduction) when applied for 40 minutes. The results of this study demonstrate that washing peaches reduced but did not completely eliminate surface microorganisms.
Alternate Bearing in Olive (Olea europaea L.)

In alternate bearing olive trees, high yield on-crop years alternate with low yield off-crop years. Research was undertaken in support of the California olive industry to determine how fruit number one year impacts floral intensity and yield the following year. Removing the on-crop of fruit before endocarp hardening (mid-July) restored summer vegetative shoot growth and inflorescence number the following spring. Delaying fruit removal to 75 days after endocarp hardening (September) significantly reduced spring bud break and floral intensity. Quantification of the fate of buds on nonbearing and bearing shoots of off- and on-crop control trees provided striking results. The majority of buds on nonbearing shoots of off-crop trees produced inflorescences, whereas most buds on nonbearing shoots of on-crop trees remained inactive through spring bloom. In sharp contrast, 74% of buds on bearing shoots of on-crop trees had abscised prior to spring bloom. A putative O. europaea FLOWERING LOCUS T (FT) gene, known to upregulate flowering in woody perennials, was expressed in buds on nonbearing shoots of off-crop trees from June through March, but was repressed in buds of bearing and nonbearing shoots of on-crop trees starting in September and October, respectively. Whereas the lack of OeFT expression in buds on bearing shoots of on-crop trees may be due to the abscission of 51% of the floral buds by September, this result taken together with the repression of OeFT in buds on nonbearing shoots of on-crop trees in October, for which floral bud abscission was not a factor, suggests the possibility that the on crop may inhibit determination of the floral meristem between September and October. Buds on nonbearing shoots of off-crop trees subsequently expressed two floral organ identify genes in March; these genes were not expressed in buds of nonbearing and bearing shoots of on-crop trees. This study is the first to provide evidence that several mechanisms in addition to inhibition of summer vegetative shoot growth, including inhibition of spring bud break, inhibition of floral development at the level of gene expression, and abscission of potential floral buds, contribute to the perpetuation of alternate bearing in olive.
Produksi, isolasi dan karakterisasi enzim dekstranase dari Arthrobacter sp. B7

Dextranase enzyme has been purified and characterized from Arthrobacter sp. B7. This enzyme was purified from the culture supernatant of Arthrobacter sp. B7 by procedure of native PAGE. The molecular size of the enzyme was estimated 72,5 kDa by SDSPAGE. The N-terminal amino acid sequence of this enzyme determined using Edman degradation techniques were APVTADVGNLHT. SDS-PAGE and native-PAGE analysis revealed that the enzyme molecule consisted of one sub-unit.
LINC00210 exerts oncogenic roles in glioma by sponging miR-328

Long non-coding RNAs (lncRNAs) have been reported to serve key roles in human cancer types, including glioma. However, to the best of our knowledge, the expression and function of lncRNA LINC00210 in glioma have not previously been investigated. The present study was conducted to explore the regulatory role of LINC00210 in glioma cells. The present study demonstrated that LINC00210 was significantly upregulated in glioma tissues, and high expression of LINC00210 was significantly associated with advanced clinical stage and poor prognosis in patients with glioma. It was found that LINC00210 knockdown significantly inhibited the proliferation and migration of U251 and T98G cells. The results of luciferase reporter assays indicated that LINC00210 could directly target microRNA (miR)-328 in glioma cells, and miR-328 expression was negatively correlated with LINC00210 expression in glioma tissues. LINC00210 knockdown significantly promoted the expression of miR-328 in U251 and T98G cells. Moreover, silencing miR-328 impaired the inhibitory effects of LINC00210 knockdown on the proliferation and migration of U251 and T98G cells. Therefore, the present results suggested that LINC00210 may exert an oncogenic role in glioma via sponging miR-328.
A simulation-based mechanistic study of turbulent wind blowing over opposing water waves

Abstract We perform large-eddy simulation (LES) and theoretical analysis to investigate the effects of opposing waves on overlying turbulent wind. The LES results show that opposing waves induce nearly antisymmetric vertical velocity $\tilde {w}$ in the wind on the two sides of the wave crest, while the streamwise velocity $\tilde {u}$ away from the surface and the air pressure $\tilde {p}$ seem symmetric. To study the mechanisms for the wave-induced airflow, we develop a viscous model by linearising the phase-averaged Navier–Stokes equations in the mapped computational curvilinear coordinate. To illustrate the flow dynamics, we split $\tilde {w}$ into an antisymmetric component and a symmetric component. The solution of the antisymmetric component of $\tilde {w}$ from the viscous curvilinear model agrees well with the LES results for different opposing wave conditions. According to the viscous curvilinear model, the large-magnitude antisymmetric component of $\tilde {w}$ is driven by the wave kinematics at the surface and amplified by the mean shear and viscous stress in the air, and it causes the strong symmetric components of $\tilde {u}$ and $\tilde {p}$. In contrast, the small-magnitude symmetric component of $\tilde {w}$ is forced by the antisymmetric $\tilde {w}$ through viscous and turbulent stresses near the surface, and it can be described by a further simplified inviscid curvilinear model away from the surface. It is discovered that the weak symmetric $\tilde {w}$ causes a slight asymmetry in $\tilde {u}$ and $\tilde {p}$, and generates a mean wave-coherent stress and the form drag on the wave surface. The wave attenuation rates quantified using the form drag agree with the published experiments.
A Fusion Method to Build A Model for Prediction Exchange Rate from USD to VND

—In this paper, the combination of the Hilbert-Huang Transform, Fuzzy logic system and an embedding theorem is described to predict the short-term exchange rate from United States dollar to Vietnamese Dong. By using the Hilbert-Huang Transform as an adaptive filter, the proposed method decreases the embedding dimension space from twelve (original samples) to four (de-noising samples). This dimension space provides the number of inputs to the fuzzy rule base system, which causes the number of rules, the time for training and the inference process to reduce. Experimental results indicated that this method not only reduces complication of the model but also achieves higher accuracy prediction than the direct use of original data.
An Analytical Optimisation Framework for Airport Terminal Capacity Expansion

This article considers how to allocate additional physical resources within airport terminals. An optimization model was developed to determine where additional resources should be placed to minimise passenger waiting times. The objective function is stochastic and can only be evaluated using discrete event simulation. As this model is stochastic and nonlinear, a Simulated Annealing (SA) metaheuristic was implemented and tested. The SA algorithm repeatedly perturbs a resource allocation solution using one of two methods. The first method is creating new solution randomly in each iteration, and the second method is local search that is mimicked by any move of the current solution of x solution chosen randomly in its neighborhood. Numerical testing shows that the random approach is best, and solutions that are 12.11% better can be obtained.
Cope's rule and the adaptive landscape of dinosaur body size evolution

The largest known dinosaurs weighed at least 20 million times as much as the smallest, indicating exceptional phenotypic divergence. Previous studies have focused on extreme giant sizes, tests of Cope's rule, and miniaturization on the line leading to birds. We use non‐uniform macroevolutionary models based on Ornstein–Uhlenbeck and trend processes to unify these observations, asking: what patterns of evolutionary rates, directionality and constraint explain the diversification of dinosaur body mass? We find that dinosaur evolution is constrained by attraction to discrete body size optima that undergo rare, but abrupt, evolutionary shifts. This model explains both the rarity of multi‐lineage directional trends, and the occurrence of abrupt directional excursions during the origins of groups such as tiny pygostylian birds and giant sauropods. Most expansion of trait space results from rare, constraint‐breaking innovations in just a small number of lineages. These lineages shifted rapidly into novel regions of trait space, occasionally to small sizes, but most often to large or giant sizes. As with Cenozoic mammals, intermediate body sizes were typically attained only transiently by lineages on a trajectory from small to large size. This demonstrates that bimodality in the macroevolutionary adaptive landscape for land vertebrates has existed for more than 200 million years.