Miracle-dz/UniFAR-FTUs huggingface dataset:
Multicenter study validates PITX2 DNA methylation for risk prediction in tamoxifen-treated, node-negative breast cancer using paraffin-embedded tumor tissue

505 Background: In hormone receptor positive, node-negative breast cancer, many patients receive chemo-endocrine therapy although endocrine therapy alone would have been sufficient in view of their excellent prognosis. In a microarray study, we recently reported that PITX2 methylation correlates strongly with the risk of recurrence after adjuvant tamoxifen. Here, we present results from a large multicenter study initiated to validate PITX2 methylation as an outcome predictor for adjuvant tamoxifen using paraffin-embedded tumor tissue. Methods: A real-time PCR assay was developed to test PITX2 methylation in paraffin-embedded tissue. Matched frozen and embedded samples (n=89) were analyzed to ensure comparability of Results: Then, we analyzed paraffin-embedded tumors of 422 node-negative patients from 9 clinical centers treated with tamoxifen alone; none of the patients had been included in the prior studies. Results: Results from the matched pairs indicated that the assay works well on paraffin-embedded m.
Vehicular Ad hoc Networks and its Application in Today’s Scenario

: Vehicular Ad hoc Network (VANET) has become the potential area of research now a day. The VANET is a subclass of Ad hoc network assisting the drivers, passengers and pedestrians in the field of safety and convenience and entertainment. In addition to the safety and convenience, VANET also supports commercial oriented applications. In this article, we are presenting the introduction of VANET and the application areas supported.
Sistem Informasi Pengaduan Pelanggaran di SPBU pada Direktorat Metrologi Bandung Berbasis Mobile

Kementerian Perdagangan Republik Indonesia Direktorat Metrologi Legal merupakan instansi pemerintah. Salah satu alat ukur yang dikelola Direktorat Metrologi Legal adalah alat ukur pada SPBU. Pengaduan pelanggaran oleh masyarakat sangat dibutuhkan sebuah instansi untuk meningkatkan kualitas kinerja. Pengaduan pelanggaran di Direktorat Metrologi saat ini masih dilakukan melalui pesan singkat atau telepon. Penyampaian pelanggaran melalui pesan singkat atau telepon ini dirasa kurang efektif karena jika terlalu banyak pesan singkat akan terjadi penumpukan pesan yang akibatnya pesan pertama masuk tidak terlihat oleh penerima pesan. Jika pengaduan dilakukan melalui telepon, ketika dua pengaduan melakukan pengaduan secara bersamaan mengakibatkan sulitnya tersambung dengan penerima pengaduan. Sistem informasi pengaduan pelanggaran berbasis mobile yang dihasilkan dari penelitian ini. Masyarakat dapat melakukan pengaduan melalui mobile phone dan Direktorat Metrologi dapat menerima pengaduan melalui web, masyarakat dapat melakukan monitoring pengaduan merupakan tujuan dari pembangunan sistem pengaduan pelanggaran ini. Manfaat yang dihasilkan adalah membantu Direktorat dalam meningkatkan kualitas pelayanan dengan menerima pengaduan pelanggaran melalui web yang dikirimkan masyarakat dengan mobile, dan sysdugaan pelanggaran. Penelitian ini menggunakan metode waterfall untuk mendukung pengembangan perangkat lunak.
Microbiological status of some commonly available food items and the effects of
microwave oven heat on the existence microflora

F U L L P A P E R Microbiological status of some commonly available food items and the effects of microwave oven heat on the existence microflora Islam, M.F. , Nur, I.T. , Islam, T. , Sultana, R. , Rezanujjaman, Md. and Acharjee, M. Department of Microbiology, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka-1217, Bangladesh Department of Molecular and Developmental Biology, Graduate School of Science and Technology, Shizuoka University, Oya 836, Suruga-ku, Shizuoka, 422-8529, Japan
Current state of the use of musculoskeletal ultrasound (MSUS) and view on the future development of MSUS training and services in Hong Kong: Results of a survey among the members of the Hong Kong Society of Rheumatology

Objective: To document the current state of the use of musculoskeletal US (MSUS) and view on the future development of MSUS training and services among the members of the Hong Kong Society of Rheumatology. Methods: A three-page anonymous questionnaire, divided into three sections (demographics, current state of the MSUS service, and view on future development of MSUS training and services), was sent (either in electronic format or in hardcopy) to 79 members (70 full members and 9 ordinary members) of the Hong Kong Society of Rheumatology. The aim is to inquire about the use of MSUS by rheumatologists, their views on the future development of MSUS training and service in Hong Kong. Results: 28 (35%) out of 79 members responded to the questionnaire (including 25 fellows and 3 trainees working in public hospitals and private sector). 25 responders (89.3%; 25/28) were using MSUS in their daily practice for making diagnoses, guiding interventions or follow-up disease. Although 90% (25/28) of the responders’ institutes provided the MSUS service by the Radiology Department, 70% of them got long waiting time, and the Radiology Department did not provide the MSUS service to every joint region. Despite the widespread use of MSUS among rheumatologists, more than 90% of the responders Editorial Open Access © 2016 Stella Pui-Yan Wong, Carmen Ho-Tze Kwan, published by De Gruyter Open. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. Stella Pui-Yan Wong, Carmen Ho-Tze Kwan* Current state of the use of musculoskeletal ultrasound (MSUS) and view on the future development of MSUS training and services in Hong Kong: Results of a survey among the members of the Hong Kong Society of Rheumatology *Corresponding author Carmen Ho-Tze Kwan, Queen Mary Hospital, Department of Medicine, E-mail: hotk@ha.org. hk Stella Pui-Yan Wong, Tseung Kwan O Hospital, Department of Medicine Unauthenticated Download Date | 7/7/19 5:52 AM 2 S. Pui-Yan Wong, C. Ho-Tze Kwan of MSUS training and services in Hong Kong.
MESENCHYMAL STEM CELLS AS AN ATTRACTIVE CANDIDATE FOR EX–VIVO GENE TRANSFER AND REGENERATIVE CELL THERAPY

INTRODUCTION Cell and Gene therapy are the advanced medicinal approaches of the 21st century. Mesenchymal stem cells have been established as immunomodulatory cells that can be obtained from multiple sources with relative ease, which have ability to home to the sites of inflammation and have not shown any oncogenic risk even after use in thousands of patients in several clinical studies and after approval of multiple products worldwide (for example Prochymal®, Alofisel®, Temcell®). Gene therapy (therapy by expression of a therapeutic gene) can be administered in two fundamental ways; in-vivo or ex-vivo. Invivo gene transfer is conducted directly by virtue of exposing the patient's body to the vectors of gene therapy. There are multiple risks associated with the in-vivo gene transfer; namely immune reaction, minimal control over cell transformation, and uncertainty of efficacy. Ex-vivo gene transfer minimizes the risks associated with immune reaction, provides exceptional control over the gene transfer process and also provides opportunity to test the expression and effectiveness of the gene transfer process. Mesenchymal stem cells offer one of the most ideal candidates for ex-vivo gene transfer as they can express therapeutic proteins, have immunomodulatory properties avoiding immune rejection, and are able to deliver targeted therapies by virtue of homing ability to the disease sites. In this review, we will focus on the use of MSCs with or without genetic enhancement and use of conditioned media derived from MSCs in the treatment of neurological diseases, immunological disorders, cardiac diseases, metabolic diseases gastrointestinal diseases and hematological diseases. In this review, we also address the use of gene modified MSCs as targeted therapies for metastatic cancers.
Direct 3-D Sparse Imaging Using Non-Uniform Samples Without Data Interpolation

As an emerging technique, sparse imaging from three-dimensional (3-D) and non-uniform samples provides an attractive approach to obtain high resolution 3-D images along with great convenience in data acquisition, especially in the case of targets consisting of strong isolated scatterers. Although data interpolation in k-space and fast Fourier transform have been employed in the existing 3-D sparse imaging methods to reduce the computational complexity, the data-gridding errors induced by local interpolation may usually result in poor imaging performance. In this paper, we directly regard the imaging problem as a joint sparse reconstruction problem from non-uniform data without interpolation in 3-D space. Combining dictionary reduction and Gauss iterative method with the optimized signal processing scheme, a sparse imaging algorithm is proposed to address the difficulty of large-scale computation involved in direct 3-D sparse reconstruction. Benefited from the optimized signal processing scheme and the avoidance of data interpolation, the direct 3-D sparse imaging (DTDSI) method proposed in this paper is of low computation scale and high imaging performance. Experiments of electromagnetic simulation data demonstrate the DTDSI method outperforms baseline methods in terms of resolving ability, lower side-lobes and higher accuracy.
Arranque de un reactor anaerobio de flujo ascendente para el tratamiento de una corriente de lixiviados proveniente de un reactor UASB

El Relleno Sanitario La Esmeralda de la ciudad de Manizales cuenta con una unidad anaerobia complementaria al reactor UASB. Esta unidad consta de dos reactores ABR (Reactor Anaerobio de Bafles) en paralelo construido para el cumplimiento de la normativa ambiental vigente de vertimiento en Colombia. Se observo que esta nueva unidad presentaba bajas remociones de DQO, debido a la falta de nutrientes en el lixiviado afluente del UASB. Despues de tres semanas de adicion continua de P-Total y N-Total, se logro mejorar las remociones de 7% al 42% de DQO. Para lograr la mejora fue necesario encontrar la dosificacion optima de nutrientes con el fin de evitar sobresaturaciones o insaturaciones, ademas de garantizar una estabilidad en la concentracion de nutrientes a lo largo de las unidades del reactor ABR debido a su diseno. La relacion optima para trabajar el lixiviado del Relleno Sanitario La Esmeralda es DQO=250: N-Total=5: P-Total=1
Clinical effectiveness of certain physiotherapies in musculoskeletal disorders

The objective of the study was to compare the effects of shockwave therapy and laser therapy on pain, neck functionality, and quality of life in patients with myofascial pain syndrome of the trapezius. 61 patients (> 18 years) were randomly allocated to two treatment groups: (1) 31 patients received soft laser therapy once daily in a 3-week period for a total of 15 sessions, (2) 30 patients received shockwave therapy once in a week for 3 weeks, totalling 3 treatments. Resting pain and pain tolerance were assessed by a 100 mm visual analogue scale; functional status and quality of life were measured by specific questionnaires (Neck Disability Index, SF-36) before and after the 3-week therapy and at the 15th week follow-up visit. All measured parameters improved significantly in both groups at week 3 and week 15. Comparing the two groups, patients receiving shockwave therapy demonstrated significantly better changes in pain tolerance (mean between-group differences at visit 1–0 = 14.911, 95% CI = 2.641–27.182, mean between-group differences at visit 2–0 = 17.190, 95% CI = 4.326–30.055 in the left trapezius), neck functionality (mean between-group differences at visit 1– 0 = 0.660, 95% CI = − 1.933 to 3.253, mean between-group differences at visit 2–0 = 1.072, 95% CI = − 2.110 to 4.254), and in all domains using SF-36 QoL questionnaire. The only parameter in which the laser group showed significantly higher benefits was at week 15 for resting pain (mean between-group differences at visit 2–0 = − 1.345, 95% CI = − 14.600 to 11.910). The results of our study point to a conclusion that both laser and shockwave therapy are effective in myofascial pain syndrome, though we found shockwave therapy to be somewhat more beneficial. Clinical trial registration number NCT03436459 (https ://clini caltr ials.gov/ct2/show/NCT03 43645 9).
Isolation of Anthocyanin Mixtures from Fruits and Vegetables and Evaluation of Their Stability, Availability and Biotransformation in The Gastrointestinal Tract

·····················································································································ii ACKNOWLEDGMENTS·································································································v VITA·······························································································································vii TABLE OF CONTENTS ·································································································ix LIST OF TABLES ·········································································································xvi LIST OF FIGURES·······································································································xvii LIST OF ABBREVIATIONS ·························································································xx
An Novel Method for Abdominal Fatness Measurement with the Help of B-Mode Ultrasonography

Subcutaneous and visceral fat acculmulat ion in abdo men has close relationship with o f Metabolic Syndro me (MS) and other d iseases, and therefore serve as impo rtant indicato rs of them. Abdo minal co mputed to mog raphy (CT) enables precise quantificat ion of the Subcutaneous Fat Area (SFA) and Visceral Fat Area (VFA ) and has been considered as the gold standard for body fatness assessment. In this paper, the d istribution of fatness accumu lat ion in abdo min ial area were studied and some p rincip les have been discovered, and we develope a novel method to measure the SFA and VFA quickly and stably with u ltrasound (US) and some d rawbacks o f existing methods have been overco me. Then, we evaluated the novel method on 100 patients. Strong correlat ion relationship between our method and CT method has been confirmed : Fo r SFA and VFA, the mean dev iation bet ween US-method and CT-method was and The term metabolic syndrome (M S), a combination of medical disorders that increases the risk of chronic dis eas es such as diabetes, hypertension, and cardiovascular disease, has been adopted by International D iabetes Federation (IDF) in 2006. M S is a major public health problem, the prevalence of which has increased worldwide. Despite differences in histology, physiology and gene expression profile among f at depots, it is generally believed that excessive fat accumulation in abdominal has similar negative health connotations. For example, both visceral fat and subcutaneous fat depots are related to insulin res istance and dyslipidemia, albeit to different degrees(5). Abdominal obes ity, colloquially known as belly fat or clinically as central obesity, is the accumulation of abdominal fat resulting in an increas e in waist size. Abdominal obesity is thought to be a fundamental pathology for M S in particular and therefore, the accurate measurement of abdominal obes ity represents an important tool in assessing the ocurring and developing of M S. There are two kinds of adipose tissue accumulation in abdomial obes ity: subcutaneous fat and vis ceral fat. Subcutaneous fat is found just beneath the skin as opposed to visceral fat which is found in the peritoneal cavity. Vis ceral fat, also known as organ fat, packes in between internal organs and the torso, as opposed to subcutaneous fat which is found underneath the skin. Since subcutaneous fat and visceral fat cannot be observed directly, the accurate assessment of them has prooven to be challenging work.
TraG: A Trajectory Generation Technique for Simulating Urban Crowd Mobility

Mobility models, which reproduce traces with basic crowd mobility patterns, are crucial for realistic mobile network simulation and performance evaluation of the planning strategies used for urban networks (such as transit network, communication network, and crowdsensing network). However, trajectories generated by traditional models are often perceived as not realistic for urban context or lack of scalability and universality. This article presents a data-driven trajectory generating technique, named as TraG, that produces synthetic trajectories with the help of some real-world trajectories. Our technique can automatically extract the context features and statistical mobility features, which characterize the mobility of a specific urban crowd from the input empirical traces and, then, regenerate more trajectories based on demand. Moreover, we also summarize the power-law scale correlation of crowd mobility based on four real-world open datasets, including public bicycle traces in New York City and Washington, D.C., taxicab traces in San Francisco and Shenzhen. Finally, we validate the proposed TraG model via the continuous San Francisco taxicab traces, and the result demonstrates that the trajectories simulated by TraG not only inherit the fundamental statistical features of crowd mobility from real traces, but also reflect the features of urban context.
Circulation in Tasman-Golden bays and Greater Cook Strait, New Zealand

ABSTRACT Analyses are presented of model simulations and Lagrangian drifter experiments designed to quantify circulation and dispersal in Tasman and Golden Bays, and their connection to Cook Strait, New Zealand. Observations made in autumn 2017 and summer 2018 are compared with numerical model results. The drifter experiments were focussed on three repeat experiments in each bay designed to measure the local horizontal eddy diffusivity. An additional experiment investigated the connection with, and flow through, Greater Cook Strait. Point by point velocities extracted from the model show low correlation with, but on average are in the same direction as observed velocities. Eddy diffusivities computed from the drifter experiments are highly variable, but the observations support the modelling. We find that the mean velocity in Tasman and Golden Bays is weak and the circulation is dominated by wind and tidal flows. The mean depth-averaged velocity shows anticyclonic flows in the south of both Tasman and Golden Bays, with cyclonic flow in the north of Golden Bay. The mean near-surface velocity is generally out of each bay and is compensated for by inward circulation at depth.
Examining the variability in network populations and its role in generative models

Abstract A principled approach to understand networks is to formulate generative models and infer their parameters from given network data. Due to the scarcity of data in the form of multiple networks that have evolved from the same process, generative models are typically formulated to learn parameters from a single network observation, hence ignoring the natural variability of the “true” process. In this paper, we highlight the importance of variability in evaluating generative models and present two ways of quantifying the variability for a finite set of networks. The first evaluation scheme compares the statistical properties of networks in a dissimilarity space, while the other relies on data-driven entropy measures to compute variability in network populations. Using these measures, we evaluate the ability of four generative models to synthesize networks that capture the variability of the “true” process. Our empirical analysis suggests that generative models fitted for a single network observation fail to capture the variability in the network population. Our work highlights the need for rethinking the way we evaluate the goodness-of-fit of new and existing network models and devising models that are capable of matching the variability of network populations when available.
Military Expenditure Economic Growth Nexus in Jordan: An Application of ARDL Bound Test Analysis in the Presence of Breaks

ABSTRACT The Hashemite Kingdom of Jordan is a nation that has persisted through turbulent times. The country’s leaders have long attempted to balance the allocation of resources between a strong military and a developing economy in their quest for stability, peace and prosperity. This paper examines and sheds further light on the relationship between Jordan’s military expenditure and its economic growth during the period 1970–2015. Using the Gregory -Hansen cointegration technique allowing for structural breaks, and the ARDL methodology this paper tests the short – and long–run equilibrium relationship between military expenditure and economic growth in Jordan. Furthermore, with the error correction model (ECM) and the CUSUM and CUSUMSQ tests, we examine the stability of the above relationship. The results reveal positive short – and long–run relationships between military expenditure and economic growth in Jordan, during the period under study. This finding has important policy implications for the Jordanian state, as it justifies the transfer of resources to the military, showing that it has not had a negative impact on economic growth.
A secure logistics model based on blockchain

ABSTRACT Modern services of logistics has developed and expanded rapidly in China. The information of package delivery is managed by the logistics enterprises. Thus, while enjoying the modern services of logistics, consumers face the threats of personal privacy disclosure. In order to address such challenges in modern services of logistics, we present techniques to exploit blockchain to secure logistics for protecting personal privacy. The main contribution is that we propose alogistics blockchain model. We implement the logistics blockchain on the decentralised and distributed platform, which shows that it is efficient and secure.
Lúpus eritematoso sistêmico a gestação e os Rins

O Lupus Eritematoso Sistemico e uma doenca cronica multifatorial de etiopatogenia desconhecida, que atinge principalmente mulheres negras em idade reprodutiva, entre 15 e 45 anos, podendo causar complicacoes renais e durante a gestacao. O presente estudo se trata de uma revisao bibliografica narrativa de aspecto qualitativo, tendo como objetivo a analise da literatura publicada em artigos de revistas cientificas sobre o lupus, a gestacao e as complicacoes renais causadas pela doenca. A coleta de dados foi realizada por meio de artigos publicados nos sites de ciencias da saude no periodo de 2005 a 2015, usando como descritores para as buscas bibliograficas os termos lupus eritematoso sistemico, gravidez, nefrite lupica, anticorpos e diagnostico clinico. A partir dos dados obtidos dos artigos consultados, foi observado que as principais complicacoes da doenca envolvem a nefrite, alteracoes hematologicas, complicacoes no sistema nervoso central, na pele e articulacoes. Essas complicacoes sao causadas, pela producao de autoanticorpos, que ao formarem complexos imunes se depositam nos orgaos citados acima. Ha alguns anos, a gestacao para pacientes com lupus era totalmente proibida, ainda hoje, trata-se de uma gestacao arriscada, tanto para a mae quanto para o feto, entretanto, o controle evolutivo da doenca antes da gestacao e fundamental. Ainda nao existe uma causa definida para o lupus, sabe-se, porem, que diferentes fatores podem desencadea-lo, tais como: mutacoes genicas; fatores ambientais; luz solar, raios ultravioleta, agentes quimicos, medicamentos, conservantes; e fatores hormonais. O lupus e uma doenca de dificil diagnostico e controle, sendo necessarios novos estudos sobre o assunto.