Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficiency and Safety of Topical Use of the Gentamicin-Impregnated Collagen Matrices in Surgical Treatment of Patients with Diabetic Foot Syndrome

The article presents literature review (web-site PubMed is used) on the use of gentamicin-impregnated collagen matrices in prevention and treatment of surgical site infections – background information, clinical and pharmacological reasoning of the use of this composite product, clinical efficiency. Meta-analysis of published research on the application of this product in treatment of patients with diabetic foot syndrome has been carried out. The authors analyzed the results of their own research of topical application of antibiotic-impregnated collagen matrices in surgical treatment of 161 patients with diabetic foot syndrome and Charcot foot in purulent stage and with osteomyelitis. ISSN 2639-9326 Research Article Citation: Vladimir N. Obolensky. Interferon-Based Antiviral Treatment of Chronic Hepatitis C in Combination with Metformin in Patients with HCV-1 Genotype and Insulin Resistance. Diabetes Complications. 2017; 1(4): 1-6.
An improved approach of high graded glioma segmentation using sparse autoencoder and fuzzy c-means clustering from multi-modal MR images

Accurate and automated brain tumor segmentation using multi modal MR images is essential for the evaluation of the disease progression in order to improve disease diagnosis and treatment planning. We present a new fully automated method for high graded brain tumor segmentation combining sparse autoencoder and multimodal Fuzzy C-means clustering. The approach utilizes multimodal MRI contrast: T1, T2, FLAIR and T1c (contrast-enhanced) for 15 high graded glioma (HGG) subjects. The objective of the proposed study is to segment tumor tissues from HGG including edema and tumor core within edema. The segmentation was performed on the training data of the multimodal brain tumor image segmentation benchmark 2015. Sparse autoencoder, which is an unsupervised learning algorithm, was used to automatically learn features from unlabeled dataset of tumor in order to segment edema. Followed by edema segmentation, tumor core was segmented from edema using multimodal FCM clustering. Evaluating the performance of the segmentation results with the ground truth yields high dice score (DS) of 0.9866±0.01 and 0.9843±0.01 for edema and tumor core respectively and high Jaccard similarity (JS) of 0.9738±0.02 and 0.9692±0.02 for edema and tumor core respectively; showed high accuracy in segmenting the complex tumor structures from multi-contrast MR scans of HGG patients. We also compared our methodology in terms of segmentation efficiency with some recent techniques reported in proceedings of MICCAI-BRATS challenge 2015.
COMBINATION OF LACTATE WITH MODIFIED EARLY WARNING SCORE AND RAPID EMERGENCY MEDICINE SCORE IN GERIATRIC PATIENTS ADMITTED TO EMERGENCY DEPARTMENT TO PREDICT 28-DAY MORTALITY

ACİL SERVİSE BAŞVURAN GERİATRİK HASTALARDA 28 GÜNLÜK MORTALİTE TAHMİNİNDE “MODIFIED EARLY WARNING SCORE” VE “RAPID EMERGENCY MEDICINE SCORE”UN LAKTAT İLE KOMBİNASYONUNUN KARŞILAŞTIRILMAS
Practical Performance Profiling: Improving the efficiency of .NET code

In Practical Performance Profiling, Jean-Philippe Gouigoux provides both the theory and practical skills necessary to analyze and improve the performance of . NET code. By focusing on the 20% of code defects that account for 80% of performance loss, Jean-Philippe Gouigoux guides the reader through using a profiler and explains how to identify and correct performance bottlenecks. This book is for all developers who wish to boost the performance of their . NET code without having to embark on the steep slopes of tuning. Jean-Philippe Gouigoux draws on over ten years' experience as a software architect specializing in this area to demystify performance in . NET code. In Practical Performance Profiling he explains how the . NET platform manages memory and uses a sample application based on a real software package to demonstrate a wide range of performance slowdowns. With clear explanations of how to set up automated test scenarios, use a profiler, diagnose problems, identify solutions and validate the results, Practical Performance Profiling makes efficient code an achievable goal for all . NET developers.
Touched by CTCF: Analysis of a multi-functional zinc finger protein

textabstractMulticellular organisms contain a complete set of genes in nearly all of their cells. However most cells are very different to each other and are able to form organs with distinct functions. The identity and survival of the cell is regulated by the activity of specific genes in time and space. Specific sets of genes encoding proteins become activated, whereas others are repressed. CTCF is a protein that mediates distinct processes of gene regulation, including transcription and the structural organization of the genome. The aim of this thesis is to investigate the different functions of CTCF by a combined analysis of CTCF-interacting proteins and by deletion of CTCF in vivo and in vitro. Using these approaches we aimed to improve our understanding of the molecular mechanism underlying its functions. Chapter 1 gives an overview of the information required to understand the foundations of studies presented and discussed in this thesis. It gives an introduction to gene regulation and how this process is influenced by chromatin modifications, nuclear organization and compartmentation. A specific nuclear compartment, the nucleolus, and its involvement in ribosomal RNA synthesis, are highlighted. Furthermore the characteristics of CTCF and its homolog CTCFL are described in detail.
Trichococcus patagoniensis sp. nov., a facultative anaerobe that grows at −5 °C, isolated from penguin guano in Chilean Patagonia

A novel, extremely psychrotolerant, facultative anaerobe, strain PmagG1T, was isolated from guano of Magellanic penguins (Spheniscus magellanicus) collected in Chilean Patagonia. Gram-variable, motile cocci with a diameter of 1.3–2.0 μm were observed singularly or in pairs, short chains and irregular conglomerates. Growth occurred within the pH range 6.0–10.0, with optimum growth at pH 8.5. The temperature range for growth of the novel isolate was from −5 to 35 °C, with optimum growth at 28–30 °C. Strain PmagG1T did not require NaCl, as growth was observed in the presence of 0–6.5 % NaCl with optimum growth at 0.5 % (w/v). Strain PmagG1T was a catalase-negative chemo-organoheterotroph that used sugars and some organic acids as substrates. The metabolic end products were lactate, formate, acetate, ethanol and CO2. Strain PmagG1T was sensitive to ampicillin, tetracycline, chloramphenicol, rifampicin, kanamycin and gentamicin. The G+C content of its genomic DNA was 45.8 mol%. 16S rRNA gene sequence analysis showed 100 % similarity of strain PmagG1T with Trichococcus collinsii ATCC BAA-296T, but DNA–DNA hybridization between them demonstrated relatedness values of <45±1 %. Another phylogenetically closely related species, Trichococcus pasteurii, showed 99.85 % similarity by 16S rRNA sequencing and DNA–DNA hybridization showed relatedness values of 47±1.5 %. Based on genotypic and phenotypic characteristics, the novel species Trichococcus patagoniensis sp. nov. is proposed, with strain PmagG1T (=ATCC BAA-756T=JCM 12176T=CIP 108035T) as the type strain.
Casein micelle size in relation with casein composition and αs1, αs2, β and Κ casein contents in goat milk

The relationship between micelle size and casein micelle composition was studied on 21 individual goat milks from animais homozygous for as1casein variants A, B2, C, E, F and O. A large variation in milk composition was obtained, as asl secretion levels varied from 7.2 g-kg"! in A milks to none in 0 milks. Mean micelle size (MMS), determined by photon correlation spectroscopy, var- ied between samples from 192 nm to 287 nm. This was explained by the different aspects of the histograms of casein distribution according to the size, determined from transmission electron microscopy data, which showed a maximum either in the low diameter range (20-130 nm) or in the large diameter region (130-260 nm), or even intermediary figures with a bimodal distribution. The caseins, as1CN, as2CN, ~CN and KCN were determined in milks from nitrogen malter determinations (N x 6.38) and RP-HPLC analysis of casein. Polynomial relations were calculated between micelle size and milk composition al parameters. MMS was correlated on one side to the as1CN and KCN lev- els in milks (g-kg'") and, on the other side, to the proportions of as1CN %, as2CN % and ~CN % in total casein. These polynomial relations allowed the prediction of the mean micelle size in milks from the casein levels, with aiS % accuracy. Monofactorial correlations also showed a significant effect of as1CN (r = -0.77), but not any of KCN. Mineral composition of milks was determined, calcium by atomic absorption spectrophotometry and phosphorus, by a colorimetrie method. Goat milks were characterized by a constant colloidal inorganic P level (12.4 (SO = 1.7) mmol-kg "). In contrast, colloidal Ca (Cac), SerineP and total colloidal P (Pc) were correlated to the total casein content. The ratio CaclPc was the most constant parameter in goat milks, amounting 1.22 (SO = 0.05), presumably characterizing an unique mode of association of caseins in milk. No significant correlation was obtained between the colloidal Ca and P levels in milks and the size of micelles. © InralElsevier, Paris. / 1 1
Media‐Based Sentiment Indices as an Alternative Measure of Consumer Confidence

The world is currently generating data at an uprecedented rate. Embracing the data revolution, case studies on the construction of alternative consumer confidence indices using large text datasets have started to make its way into the academic literature. These 'sentiment indices' are constructed using text-based analysis. A subfield within computational linguistics. In this paper we consider the feasibility of constructing online sentiment indices using large amounts of media data as an alternative for the conventional survey method in South Africa. A clustering framework is adopted to provide an indication of feasible cadidate sentiment indices that best reflect the traditional survey based confidence consumer index conducted by the BER. The results indicate that the best candidate indices are linked to a single data source with a focus on using specialised financial dictionaries. Finally, composite indices for consumer confidence is constructed using Principle Component Analysis. The resulting indices' high correlation with the traditional consumer confidence index provide motivation for using media data sources to track consumer confidence within an emerging market such as South Africa using sentiment based techniques
Managing non‐target, data‐poor species using catch limits: lessons from the Alaskan groundfish fishery

The 2006 reauthorisation of the Magnuson-Stevens Fishery Conservation and Management Act re- quires annual catch limits for all target and non-target species within federally managed fisheries in the United States. In Alaska, both target and non-target species in the Alaska groundfish fisheries have been managed using catch limits since the early 1990s. Non-target species that are caught incidentally in a fishery require monitoring to ensure that the population is not negatively impacted by commercial fishing. Resource assessment scientists have been challenged with obtaining sufficient data to recommend an acceptable catch level for management of these species. This paper reviews three case studies where a catch limit is determined for non-target species when certain data are limited: (1) varying levels of biomass and catch data for all species within a species group or complex; (2) adequate catch data but no biomass data; (3) emerging target fishery of data-poor species, plus an example of how a complex of ecosystem component species is managed.
Crocin and crocetin derivatives inhibit skin tumour promotion in mice

The addition of 100 μg/mL of a 50% EtOH extract of Crocus sativus (ECS) exhibited significant inhibitory effects on EBV‐EA activation and preserved the high viability of Raji cells. The attenuating effect of ECS was dose‐dependent. The oral administration of ECS demonstrated an inhibitory effect on two‐stage carcinogenesis of mouse skin papillomas, using DMBA as an initiator and TPA as a promoter. Crocetin gentiobiose glucose ester and crocetin di‐glucose ester were less potent than crocin in inhibiting the EBV‐EA induction effect. When crocin was applied before each TPA treatment, it delayed the formation of papillomas; only about 10% of mice bore papillomas at 9 weeks of promotion and after 13 weeks of promotion 20% of mice still bore no papilloma. The effect of crocin was not mimicked by gentiobiose or glucose alone. © 1998 John Wiley & Sons, Ltd.
Enhancing the Quality of Student Learning Using Distributed Practice

Whether you are an educator or a student, effective time management is critical to achieving success in the formal education system. For educators, the expectation is that a significant amount of curriculum can be covered in a condensed period of time. The goal is to maximize the amount of learning that takes place in the classroom so that students are prepared for the grade level or course that will follow. For students, the expectation is that a range of subject materials will be studied and tested in a short amount of time. This system of learning prioritizes the quantity of knowledge conveyed to students over the quality of students’ learning – that is, long-lasting comprehension and retention of the material. In preparation for an upcoming test or exam, teachers and students must decide what material to review and when and how to review it. To maximize the use of limited learning time, it is important to identify learning strategies that will be not only effective but also efficient tools for promoting long-term retention of classroom materials. The field of cognitive psychology offers a wealth of insight on how to enhance knowledge retention. Particularly, researchers have consistently shown the benefit of repetition or reviewingof newly learned informationon long-termmemory.As explained in the writings of memory researcher Ebbinghaus (1885/1964), “with any considerable number of repetitions a suitable distribution of them over a space of time is decidedly more advantageous than the massing of them at a single time” (p. 89). This phenomenon is called the distributed practice effect or spacing effect, and it refers to the finding that when reviewing previously learned material, distributing or “spacing” a set amount of study time across sessions leads to better memory performance in the long run than “massing” or cramming the same amount of study time into a single session. A typical research design for investigating the spacing effect consists of two study events and one test event. During the first study event, new material is introduced and learned (sometimes to a criterion); during the second study event, the same material is reviewed; and during the test event, the material is tested (Figure 22.1). The time interval between the first and second study events is referred to as the interstudy interval; it can be short/ massed (e.g., immediate or a few seconds later) or long/spaced (e.g., minutes, hours, or days later). The time interval between the last study event and the test event is referred to as the retention interval; it can also be short (e.g., an immediate test or a test in 5minutes) or long (e.g., a test amonth or year away). Therefore, the distributed practice effect can be studied in both single-session experiments as well as multiday experiments.
Role expansion as a persuasion process

Evidence establishes that employees often expand their roles to take on broader responsibilities in response to direct requests from others. However, surprisingly little research has investigated the interpersonal influence processes through which individuals convince others to expand their roles. We develop a conceptual framework to explain how senders persuade receivers to accept role expansion requests. Our framework describes why senders often fail to tailor their requests to receivers’ values, identifies the conditions under which this systematic bias is eliminated, and suggests strategies for senders to tailor their requests more effectively. Our perspective highlights how role expansion is often a reactive—rather than proactive—process in which interpersonal influence is a key building block.
Milk composition and yield changes with advancing pregnancy in dairy buffaloes (Bubalus bubalis)

Th e changes in the composition of milk with advancing pregnancy were investigated in Nili-Ravi dairy buff aloes. Forty lactating buff aloes were used, within 2-3 months postpartum. Th e animals were grouped as high, moderate, and low yielders; synchronized for estrus; and inseminated artifi cially. Milk yield was recorded daily and sampled fortnightly for analysis. Th e data were analyzed using the univariate weighted mean and general linear model. Decline in milk yield became signifi cant aft er the 8th week post-conception. Th e high yielders had the lowest fat contents. Milk fat increased signifi cantly during succeeding weeks post-conception. Th e highest fat level (8.5%) was observed in week 22. Th e solid-not-fat (SNF) was higher during the initial 8 weeks. Protein concentration declined with advancing pregnancy. Th e mineral contents were lower up to 8 weeks and increased later. It was concluded that milk fat concentrations increased linearly from week 2 to 22, while protein showed the opposite pattern in dairy buff aloes. SNF and lactose initially decreased up to week 14 but increased later on. Th is study suggests that milk composition from dairy buff aloes changes with advancing pregnancy, making it suitable for various types of human consumers.
CHROMOSOME PAIRING AND ASSOCIATIONS AT MEIOSIS IN HAPLOID SOYBEAN (GLYCINE MAX)

Nine haploid plants (2n = 20) of soybean (Glycine max [L.] Merr.) (2n = 40) were examined for meiotic chromosome pairing. At pachytene, from 0 to 6 regions of apparent chromosome pairing were observed per cell. From 0 to 4 bivalents per cell were observed at diakinesis and 0 to 5 at MI-AI. Secondary associations were commonly observed at MI-AI, although these may have been artifacts of chromosomal stickiness. The degree of pairing suggests considerable duplication of the soybean genome, indicative of polyploidy. The haploids were obtained from genetic male-sterile (ms1/ms1) seed parents. All the haploids produced coenocytic microspores, a characteristic also common in the ms1/ms1, diploid genotype, which indicated that the haploids were hemizygous for ms1 and were of parthenogenetic origin.
Water quality changes in golf course irrigation ponds transitioning to reuse water

Irrigation ponds on nine golf courses in southern Nevada were monitored for water quality over a 1600-day period. Three of the golf courses were fresh water courses, three were courses scheduled to transition to reuse water during the study period and three were long term users of reuse water. Salinity (electrical conductivity (EC)), NO 3 - -N, PO 4 -P, pH, algal chlorophyll concentration, clarity, temperature, oxygen, and all major cations and anions were analyzed on a monthly basis. A selected fairway on each course was equipped with water meters to assess irrigation volumes on a bimonthly basis. Estimates of salt and NO 3 - -N loading on fairways were made by weighting irrigation volumes with concentra- tions of salt (assuming 700 mg·L -1 per dS·m -1 ) and NO 3 - -N measured in the irrigation ponds. Pond spectral refl ectance measurements were obtained on a single monitoring day and cor- related with water quality parameters. EC, temperature, NO 3 - -N, PO 4 -P, algal chlorophyll concentration and clarity all demonstrated signifi cant changes in all irrigation ponds that transitioned to reuse water (p < 0.05). Multiple regression analysis revealed that as much as 75% of the variability in pH in some irrigation ponds could be accounted for based on water quality parameters measured, with higher R 2 values associated with elevated HCO - 3 concentrations. Spectral refl ectance (individual wave bands and spectral indices) was shown to be correlated with pH, clarity and algal chlorophyll concentration (R 2 = 0.66 ** to 0.82 *** ) with a well defi ned threshold relationship between clarity and the spectral index R705/R670. Average yearly NO 3 - -N loads on fairways averaged 8.5 kg·ha -1 ·yr -1 on fresh water courses, 86.5 kg·ha -1 ·yr -1 on transition courses and 209.8 kg·ha -1 ·yr -1 on long term reuse courses (all signifi cantly different at p = 0.05). Average yearly salt loads on fairways averaged 11,959 kg·ha -1 ·yr -1 on fresh water courses, 14,675 kg·ha -1 ·yr -1 on transition courses and 27,445 kg·ha -1 ·yr -1 on long term reuse courses (long term signifi cantly different at p = 0.05). Such results indicate that signifi cant attention must be given to irrigation strategies used on reuse irrigated golf courses to properly manage for higher nitrogen and salt loads.
Imperializing Norden

The two pre-Napoleonic Nordic polities are best understood as empires. Drawing on recent analytical and historical scholarship on empires, I argue that 17th and 18th century Denmark, on which the piece concentrates, was very much akin to the other European empires existing at the time. Read in this light, national identities within the fragments of the empire appear similar. Nationalisms are all shaped directly on the Danish model, having at the same time Denmark as their constitutive cultural other. The introduction notes that, where all European imperial experiences are concerned, overseas territories had the most wounds inflicted upon them. We would not know this if we considered Faroese, Icelandic and Norwegian nationalism in isolation. These polities, Norway in particular, participated in and benefited from the colonial policies of the empire. This notwithstanding, their national identities insist that these nations were on the receiving – as opposed to the imposing – end of imperialism. This is a historically unwarranted and ethically problematic stance requiring further discussion.
A note on the effect of Aspergillus oryzae fermentation extract on the rumen fermentation of sheep given straw

Fondevila, M. , Newbold, J., Hotten, P. M. , Orskov, E. R. (1990). A note on the effect of Aspergillus oryzae fermentation extract on the rumen fermentation of sheep given straw. Animal Production Science, 51 (2), 422-425.
Phylogeography of the East Asian polymitarcyid mayfly genus Ephoron (Ephemeroptera: Polymitarcyidae): a comparative analysis of molecular and ecological characteristics

In East Asia, the mayfly genus Ephoron, a member of Polymitarcyidae, has been classified into three species: Ephoron eophilum, Ephoron limnobium, and Ephoron shigae. Using the nuclear histone 3 and internal transcribed spacer 1 and mitochondrial 16S rRNA and cytochrome c oxidase subunit I genes, we investigated the phylogenetic relationships of these mayflies. Ephoron limnobium formed polyphyletic relationships within the clade of Japanese E. shigae and shared identical sequences with E. shigae, suggesting that E. limnobium is a synonym of E. shigae. Monophyly was supported in E. eophilum, Korean E. shigae, and E. limnobium + Japanese E. shigae. Ephoron eophilum that co-occurs with the other Ephoron species has several peculiar traits in its adult swarming period and karyotype. This suggests that both pre- and post-zygotic isolation are likely to have promoted speciation of these Ephoron species. The divergence between E. eophilum and E. shigae would have occurred from the late Late Miocene to Early Pliocene according to the Bayesian relaxed clock model calibrated using the mitochondrial substitution rate. The area currently inhabited by E. eophilum emerged above sea level some 0.1 Mya, suggesting that E. eophilum moved into this area from other areas that it occupied prior to this time. © 2013 The Linnean Society of London, Biological Journal of the Linnean Society, 2013, 109, 181–202.