Miracle-dz/UniFAR-FTUs huggingface dataset:
Tourism and Economic Globalization: An Emerging Research Agenda

Globalization characterizes the economic, social, political, and cultural spheres of the modern world. Tourism has long been claimed as a crucial force shaping globalization, while in turn the developments of the tourism sector are under the influences of growing interdependence across the world. As globalization proceeds, destination countries have become more and more susceptible to local and global events. By linking the existing literature coherently, this study explores a number of themes on economic globalization in tourism. It attempts to identify the forces underpinning globalization and assess the implications on both the supply side and the demand side of the tourism sector. In view of a lack of quantitative evidence, future directions for empirical research have been suggested to investigate the interdependence of tourism demand, the convergence of tourism productivity, and the impact of global events.
Factors Related to Obstacle Crossing in Independent Ambulatory Patients With Spinal Cord Injury

Abstract Background/Objectives: To evaluate factors related to the ability of ambulatory patients with spinal cord injury (SCI) to walk over small obstacles. Study Design: Cross-sectional study. Methods: Thirty-four patients with SCI (ASIA impairment scale [AIS] D) who were able to walk independently at least 10 m with or without walking devices were recruited for the study. Participants were required to walk over small obstacles (1,4, and 8 cm in height or width; total of 6 conditions). A “fail” was recorded when either the lower limbs or the walking device contacted the obstacle. Multiple logistic regression models were applied to determine the effects of walking devices (presence or absence), SCI levels (tetraparesis or paraparesis), and SCI stages (acute or chronic) on the ability of obstacle crossing. Results: Fifteen participants (44%) failed to adequately clear the foot or walking device over obstacles in at least one condition (range 1–3 conditions). After adjusting for covariates, the chance of failure on obstacle crossing was greatly increased with the use of walking devices (odds ratio = 8.50; 95% CI = 0.85−75.03) Conclusions: Gait safety in independent ambulatory participants with SCI remains threatened. Participants who walked with walking devices encountered a greater chance of failing to walk over obstacles as a result of inefficiently moving the foot or walking device over small obstacles. Thus, instead of training in an empty/ quiet room, rehabilitation procedures should incorporate contextual conditions that patients encounter at home and in the community in order to minimize risk of injury and prepare patients to be more independent after discharge.
Relative effects of bacterial and protozoan predators on survival of Escherichia coli in estuarine water samples

The relative effect of protozoan and bacterial predators on the survival of Escherichia coli in estuarine water samples was examined. Predacious protozoa exerted their major influence on E. coli destruction during the first 2 days of a 10-day-decline period. Inhibition of protozoa after day 2 had little effect on E. coli survival. Bacterial predators also contributed to E. coli destruction but in natural estuarine water samples were maintained at lower levels due to "grazing" by predacious protozoa.
Effects of vitamin-B complex supplementation on periodontal wound healing.

BACKGROUND Reports have demonstrated that nutrient supplements, in particular vitamin-B complex (Vit-B), can positively influence wound healing processes. However, limited information is available on the effects of Vit-B on periodontal wound healing. METHODS A total of 30 patients (13 males, 17 females) presenting with generalized moderate to severe chronic periodontitis were enrolled in this study. All subjects presented > or = two teeth in the same sextant with probing depth (PD) > or =5 mm and bleeding upon probing (BOP) in need of access flap surgery (AFS). This study was a randomized, double-masked, placebo-controlled clinical trial. Subjects were instructed to take one capsule a day of either Vit-B (50 mg of the following: thiamine HCl, riboflavin, niacinamide, d-calcium pantothenate, and pyridoxine HCl; 50 microg each of d-biotin and cyanocobalamin; and 400 mcg of folate) or placebo for 30 days following AFS. Clinical attachment levels (CAL) and N-benzoyl-dl-arginine-2-naphthylamide (BANA) test scores were measured at baseline and at 90 and 180 days following surgical intervention. Assessments of the healing response were also performed using BOP, gingival index (GI), and plaque index (Pl) at baseline and 7, 14, 30, 90, and 180 days. The mean results of each parameter were averaged within a group. Differences between groups were analyzed by using repeated measures analysis of variance (ANOVA). RESULTS Both groups experienced comparable levels of PD reduction following AFS (test: -1.57 +/- 0.34; control: -1.50 +/- 0.21). Changes in mean CAL were more favorable in Vit-B supplemented subjects (test: +0.41 +/- 0.12; control: -0.52 +/- 0.23; P = 0.024). Stratified data demonstrated significantly better results for the test group in both shallow (test: -0.08 +/- 0.03; control: -1.11 +/- 0.27; P = 0.032) and deep sites (test: +1.69 +/- 0.31; control: +0.74 +/- 0.23; P = 0.037). No significant differences were observed between groups regarding PI, GI, and BOP. BANA test values were significantly reduced in both groups after surgical treatment and no significant differences were noted between groups. CONCLUSION Vitamin B-complex supplement in combination with AFS resulted in statistically significant superior CAL gains when compared to placebo.
Antimicrobial activity of lupulone against Clostridium perfringens in the chicken intestinal tract jejunum and caecum.

OBJECTIVES Owing to the spread of antibiotic resistance among human infectious agents, there is a need to research antibiotic alternatives for use in animal agricultural systems. Antibiotic-free broiler chicken production systems are known to suffer from frequent outbreaks of necrotic enteritis due in part to pathogenic type A Clostridium perfringens. Hop (Humulus lupulus) bitter acids are known to possess potent antimicrobial activity. Lupulone was evaluated for in vivo antimicrobial activity to inhibit C. perfringens in a chick gastrointestinal colonization model. METHODS Using a week-2 per os inoculated C. perfringens chicken colonization model, C. perfringens counts in mid-intestinal and caecal contents were compared between chickens administered lupulone at 62.5, 125 and 250 ppm in drinking water versus 0 ppm control. Results At day 22, post-hatch intestinal C. perfringens counts of lupulone-treated chickens were significantly lower (P < 0.05) than water-treated control groups in both jejunal and caecal sampling sites across all lupulone dosages tested. CONCLUSIONS Lupulone administered through water inhibits gastrointestinal levels of inoculated pathogenic clostridia within the chicken gastrointestinal tract. Lupulone was effective within the chemically complex mixture of material within the gastrointestinal tract, thereby making this agent a target of further research as an antibiotic alternative for this and possibly other intestinal infections.
Chapter 3: Agenda-Shaping in the European Parliament and the European Commission’s right of legislative initiative

: The European Parliament (EP) is the only democratically elected body in the European Union. Yet, unlike most parliaments, it has no formal right of legislative initiative. Initiating legislation lies almost solely with the EU's executive bodies, the European Commission, and – to a li-mited extend – the European Council and the Council of Ministers. This paper investigates how the EP can and does influence the Commission to initiate legislation and to hold the Commission accountable in these areas. We therefore examine the process, institution, and impact of the EP’s “Non-Legislative Own-Initiative Reports” (INI) and its “Legislative Own-Initiative Reports” (INL, based on Art. 225 TFEU). The paper covers the 5th, 6th and 7th legislative terms. Based on a complete and original set of data on INI- and INL-dossiers, it offers key insights into the informal (co-)leadership capacities of the European Parliament. sation. Legislative own-initiative reports are exempted from the quota of si-multaneous reports.
Branching ratios of radiative transitions in O VI

We study the branching ratios of the allowed and forbidden radiative transitions among the first few (9) fine structure levels of O VI using relativistic coupled-cluster theory. We find irregular patterns for a number of transitions within n-complexes with n ⩽ 4. We have used the existing values of the allowed electric dipole (E1) transition as a benchmark of our theory. Good agreement with the existing values establish accuracies of not only the theoretical method but the basis function as well. In general, the electric quadrupole (E2) transition probabilities are greater in magnitude than magnetic dipole (M1) transition probabilities, whereas for medium atomic transition frequencies they are of the same order of magnitude. On the other hand, if the transitions involved are in between two fine-structure components of the same term, then the M1 transition probability is more probable than that of E2. The results presented here in tabular and graphical form are compared with the available theoretical and observed data. Graphical analysis helps to understand the trends of electric and magnetic transitions for the decay channels presented here. Our calculated values of the lifetimes of the excited states are in very good agreement with the available results.
A statistical approach to interactive image segmentation

Interactive segmentation aims to separate an object of interest from the rest of an image. This problem in computer vision is known to be hard, and very few fully automatic vision systems exist which have been shown to be accurate and robust under all sorts of challenging inputs. Most of the previous works require users to trace the whole boundary of the object. When the object has a complicated boundary, or the object is in a highly-textured region, users have to put great effort into iteratively correcting the selection. To solve this problem, most researchers rely on computing cost function for the purpose of control on the boundary of the region. Minimizing cost function yields a large, sparse system of linear equations. This paper presents a new interactive algorithm by introducing new equations for image foreground background separation. In addition we propose Edge-stopping function, a powerful tool for automatically controlling the update of seed colors with the boundaries of the image. Results show that the new method works effectively and provides an alternative computational algorithm for building interactive image editing tools.
FTY720 Analogues as Sphingosine Kinase 1 Inhibitors

Sphingosine kinase 1 (SK1) catalyzes the conversion of sphingosine to the bioactive lipid sphingosine 1-phosphate. We have previously demonstrated that FTY720 and (S)-FTY720 vinylphosphonate are novel inhibitors of SK1 activity. Here, we show that (S)-FTY720 vinylphosphonate binds to a putative allosteric site in SK1 contingent on formation of the enzyme-sphingosine complex. We report that SK1 is an oligomeric protein (minimally a dimer) containing noncooperative catalytic sites and that the allosteric site exerts an autoinhibition of the catalytic site. A model is proposed in which (S)-FTY720 vinylphosphonate binding to and stabilization of the allosteric site might enhance the autoinhibitory effect on SK1 activity. Further evidence for the existence of allosteric site(s) in SK1 was demonstrated by data showing that two new FTY720 analogues (a conjugate of sphingosine with a fluorophore and (S)-FTY720 regioisomer) increased SK1 activity, suggesting relief of autoinhibition of SK1 activity. Comparisons with the SK1 inhibitor, SKi or siRNA knockdown of SK1 indicated that (S)-FTY720 vinylphosphonate and FTY720 behave as typical SK1 inhibitors in preventing sphingosine 1-phosphate-stimulated rearrangement of actin in MCF-7 cells. These findings are discussed in relation to the anticancer properties of SK1 inhibitors.
Oral health risks associated with HLA‐types of patients undergoing hematopoietic stem cell transplantation

Aim: Dental caries, gingivitis and periodontitis are frequent long‐term complications after hematopoietic stem cell transplantation (HSCT). Not all patients are affected equally. As HLA‐genotypes are associated with many functions of the immune system we made use of our long‐standing oral health program in HSCT recipients to compare oral health data with recipient HLA‐antigens.
Regulatory control and impulsivity relate to resting frontal activity

Abstract Gray’s Reinforcement Sensitivity Theory (RST) asserts three core personality systems: the behavioral approach system (BAS), the fight-flight-freeze system (FFFS) and the revised behavioral inhibition system (r-BIS). Past models of frontal activity link greater relative left frontal activity with Carver and White’s (1994) BAS scale and trait impulsivity and greater relative right frontal activity with Carver and White’s (1994) BIS scale. However, the original BIS scale assesses both FFFS and r-BIS. Past work linking the BIS scale and right frontal activity does not indicate which system is related to right frontal activity. The current study (n = 182) examined frontal asymmetric activity with personality traits associated with approach (BAS), withdrawal (FFFS-Fear), behavioral inhibition (BIS-Anxiety) and impulsivity (UPPS-P). Resting frontal cortical activity was recorded using electroencephalography (EEG), and the traditional alpha band was examined. Greater BIS-Anxiety related to greater relative right frontal activity. Impulsivity related to less relative right frontal activity. BAS and FFFS-Fear (approach and withdrawal motivation) did not relate to asymmetric frontal activity. Regulatory control processes associated with r-BIS and impulsivity, rather than withdrawal motivation associated with FFFS, may be more closely related to right frontal activity.
The effect of quantitative easing on stock prices: a structural time series approach

ABSTRACT A structural time series model is estimated and tested to examine the effect of quantitative easing (QE) on US stock prices. The model is estimated by maximum likelihood in a Time-varying parametric (TVP) framework, using the S&P 500 index as the dependent variable and the Fed’s balance as an explanatory variable in addition to the unobserved components accounting for the behaviour of variables that do not appear explicitly in the equation. The results show that QE had a sizeable, but not exclusive, effect on stock prices and that stock prices were also affected by other missing variables and cyclical movements. Several explanations are presented for the rise of the US stock market in the post-QE period, particularly since the election of Donald Trump.
Cytokeratin Staining in Merkel Cell Carcinoma: An Immunohistochemical Study of Cytokeratins 5/6, 7, 17, and 20

Merkel cell carcinoma is an aggressive cutaneous neoplasm with neuroendocrine differentiation that carries a poor prognosis. Its homogeneous morphology is easily confused with lymphoma, leukemia, metastatic small cell carcinoma, and poorly differentiated cutaneous malignancies. Histopathologic diagnosis frequently requires support by immunohistochemistry. The authors investigated cytokeratins (CKs) 5/6, 7, 17, and 20 staining in paraffin sections of 26 Merkel cell carcinomas to expand the knowledge of the CK staining profile of this entity. Reactivity with anti-CK 20 was demonstrated in 23 of 26 Merkel cell carcinomas (88%). All three CK 20–negative tumors showed punctate staining with anti-keratin CAM5.2. Six of 26 tumors (23%) were positive for CK 7, a finding not previously reported. The staining patterns for both CKs 20 and 7 ranged from punctate (perinuclear) to localized (confined to half of the cytoplasm) to diffuse. Punctate CK 20 staining was seen in 17 of 26 cases but was the predominant pattern in only 10 cases. Antibodies to CKs 5/6 and 17 were each negative in the 13 cases for which these stains were performed. Both the positive and negative elements of the CK profile of this distinctive neoplasm provide additional useful diagnostic information for the differential diagnosis between Merkel cell carcinoma and other carcinomas that may simulate it. The authors note that the classically described perinuclear dotlike keratin staining pattern is not universally seen with CK 20 and that CK 7 staining may be seen in a subset of Merkel cell carcinomas.
Revisiting Majority-Minority Districts and Black Representation

What is the minimum black population necessary to elect African-American state lawmakers? We offer the most comprehensive examination of the election of black state legislators in the post-Thornburg v. Gingles (1986) era. We begin by charting changes in the partisan affiliation of state legislators and the percentage of black legislators from 1971 to 2016. This descriptive assessment is undertaken according to important regional (Non-South and South) and subregional (Rim South and Deep South) contexts in American politics. We then perform multivariate analyses of the likelihood of electing black legislators across three periods following the marked increase in the creation of majority-minority districts (1993–1995, 2003–2005, 2013–2015). Because of sectional variation in the partisan strength of the major parties, the probability of achieving black representation is significantly different depending upon whether a contest occurs in the Non-South, Rim South, or Deep South, with the latter constituting of the highest threshold of black population necessary to elect an African-American. By merging an original dataset on state legislative elections with the most complete evaluation of the factors shaping the election of black lawmakers, our findings shed new light on minority representation and how sectional differences greatly affect the electoral success of African-Americans.
Characterization of Genetic Differences between Mycobacterium avium subsp. paratuberculosis Type I and Type II Isolates

ABSTRACT A combination of representational difference analysis and comparative DNA sequencing revealed that four type I (sheep) isolates of Mycobacterium avium subsp. paratuberculosis were differentiated from nine type II (bovine) isolates by the presence of an 11-bp insertion in a novel M. avium subsp. paratuberculosis-specific region of genomic DNA. Further, our studies show that M. avium subsp. paratuberculosis type I isolates contain three type-specific loci that are missing in M. avium subsp. paratuberculosis type II but are present in M. avium subsp. avium. Taken together, the results are consistent with the hypothesis that M. avium subsp. paratuberculosis type I strains are an evolutionary intermediate between M. avium subsp. avium and M. avium subsp. paratuberculosis type II isolates or share a subset of M. avium subsp. avium type-specific loci through horizontal transfer.
The effect of direct press support on the diversity of news content in Norway

ABSTRACT The main question of this article is to what extent state financial support systems contribute to the diversity of topics in online news. Hereunder we investigate the impact of direct press support on the diversity of online news in Norway. The analysis applies LDA (Latent Dirichlet allocation) on a corpus of 726,889 computationally gathered news articles from 160 Norwegian newspapers collected October–December 2015 and 2016. Results show a proportionate degree of variety, balance, and disparity between topics in the Norwegian news landscape. While press supported newspapers give relatively higher attention to local politics and rural industries, overall, direct production support primarily supports pluralism aims by sustaining a heterogeneous newspaper structure.
In vitro and in vivo application of RNA interference for targeting genes involved in peritrophic matrix synthesis in a lepidopteran system

Abstract The midgut of most insects is lined with a semipermeable acellular tube, the peritrophic matrix (PM), composed of chitin and proteins. Although various genes encoding PM proteins have been characterized, our understanding of their roles in PM structure and function is very limited. One promising approach for obtaining functional information is RNA interference, which has been used to reduce the levels of specific mRNAs using double‐stranded RNAs administered to larvae by either injection or feeding. Although this method is well documented in dipterans and coleopterans, reports of its success in lepidopterans are varied. In the current study, the silencing midgut genes encoding PM proteins (insect intestinal mucin 1, insect intestinal mucin 4, PM protein 1) and the chitin biosynthetic or modifying enzymes (chitin synthase‐B and chitin deacetylase 1) in a noctuid lepidopteran, Mamestra configurata, was examined in vitro and in vivo. In vitro studies in primary midgut epithelial cell preparations revealed an acute and rapid silencing (by 24 h) for the gene encoding chitin deacetylase 1 and a slower rate of silencing (by 72 h) for the gene encoding PM protein 1. Genes encoding insect intestinal mucins were slightly silenced by 72 h, whereas no silencing was detected for the gene encoding chitin synthase‐B. In vivo experiments focused on chitin deacetylase 1, as the gene was silenced to the greatest extent in vitro. Continuous feeding of neonates and fourth instar larvae with double‐stranded RNA resulted in silencing of chitin deacetylase 1 by 24 and 36 h, respectively. Feeding a single dose to neonates also resulted in silencing by 24 h. The current study demonstrates that genes encoding PM proteins can be silenced and outlines conditions for RNA interference by per os feeding in lepidopterans.
Walking trials in postmenopausal women: effect of one vs two daily bouts on aerobic fitness

We compared the effects of one vs two daily bouts of walking on aerobic fitness and body composition in postmenopausal women. One hundred and thirty‐four subjects were randomized into exercise groups or a control group and 130 completed the study. The subjects walked 5 d/week for 15 weeks at 65% of their maximal aerobic power expending 300 kcal (1255 kJ) in exercise in one (Group S1) or two daily sessions (Group S2). VO2max was measured in a direct maximal treadmill test. Body mass index (BMI) was calculated and the percentage of body fat (fat%) estimated using skinfold measurements. The net change in the VO2max was 2.5 mL min/kg (95% CI 1.5, 3.5) (8.7%) in Group S1 and 2.5 mL min/kg (95% CI 1.5, 3.5) (8.8%) in Group S2. The net change in body mass was −1.2 kg (95% CI−1.9, −0.5) in Group S1 and −1.1 kg (95% CI −1.8, −0.4) in Group S2. The net fat% change was −2.1% (95% CI−2.7, −1.4) in Group S1 and −1.7% (95% CI−2.3, −1.0) in Group S2. Exercise improved the maximal aerobic power and body composition equally when walking was performed in one or two daily bouts.