Miracle-dz/UniFAR-FTUs huggingface dataset:
Oncocytic Type Intraductal Papillary Mucinous Neoplasm Mimicking Mucinous Cystic Neoplasm of the Pancreas

Oncocytic type intraductal papillary mucinous neoplasm is a newly defined subgroup of intraductal papillary mucinous neoplasms. A 35-year-old woman presented complaining of epigastric pain for one month. Enhanced computed tomography revealed a multilocular cystic mass in the distal body and tail of the pancreas. Endoscopic retrograde cholangiopancreatography showed no communication between the mass and the main pancreatic duct. The patient underwent a distal pancreatectomy and splenectomy. Microscopical examination showed a fibrous cyst wall; polypoid tumors exhibiting thin stalks, with extensive arborizing papillary growths from these stalks; and a focally cribriform pattern, lined by plump cells with abundant eosinophilic and granular cytoplasm. Red granules were detected in the cytoplasm of tumor cells on modified Gomori trichrome stain. Ultrastructurally, the tumor cells contained abundant cytoplasm packed with numerous mitochondria and intracellular and intercellular lumina. We describe an oncocytic type intraductal papillary mucinous neoplasm having the clinical characteristics of a mucinous cystic neoplasm.
Optimized Deployment Plans for Platform as a Service Clouds

We approximately solve the problem of computing deployment plans of multiple cloud services with soft real-time constraints. We recognize that this is a generalized bin packing problem with fragmentable items. We formalize the problem domain and develop an autonomous deployment planning system with soft real-time constraints. The system incorporates a genetic algorithm with quadratic worst-case time complexity for approximately solving the packing problem, providing a service deployment plan with an optimal number of servers and an approximately optimal number of service instances.
A New Persistent Labelling Scheme for XML

: With the growing importance of XML in data exchange, much research has been done in providing flexible query facilities to extract data from structured XML documents. Thereby, several path indexing, labelling and numbering scheme have been proposed. However, if XML data need to be updated frequently, most of these approaches will need to re-compute existing labels which is rather time consuming. The goal of the research reported in this paper is to design a persistent structural labelling scheme, namely a labelling scheme where labels encode ancestor-descendant relationships and sibling relationship between nodes but need not to be changed when the document is updated.
Hyena Myths and Realities

Hyenas, first of all, were regarded as scavengers and consumers of carrion. In his Natural History, Pliny the Elder (A.D. 23-79) spoke of them as the only animals that dig up graves in search of corpses (ab uno animali sepulchra erui inquisitione corporum). Conrad Gesner, the great sixteenth-century cataloger of natural history, reported that they gorge themselves so gluttonously after finding a corpse that their bellies swell to become taut as a drum. They then seek a narrow place between two trees or stones, force themselves through it, and extrude the remains of their meal simultaneously at both ends.
Interaction between hindbrain and spinal networks during the development of locomotion in zebrafish

Little is known about the role of the hindbrain during development of spinal network activity. We set out to identify the activity patterns of reticulospinal (RS) neurons of the hindbrain in fictively swimming (paralyzed) zebrafish larvae. Simultaneous recordings of RS neurons and spinal motoneurons revealed that these were coactive during spontaneous fictive swim episodes. We characterized four types of RS activity patterns during fictive swimming: (i) a spontaneous pattern of discharges resembling evoked high‐frequency spiking during startle responses to touch stimuli, (ii) a rhythmic pattern of excitatory postsynaptic potentials (EPSPs) whose frequency was similar to the motoneuron EPSP frequency during swim episodes, (iii) an arrhythmic pattern consisting of tonic firing throughout swim episodes, and (iv) RS cell activity uncorrelated with motoneuron activity. Despite lesions to the rostral spinal cord that prevented ascending spinal axons from entering the hindbrain (normally starting at ∼20 h), RS neurons continued to display the aforementioned activity patterns at day 3. However, removal of the caudal portion of the hindbrain prior to the descent of RS axons left the spinal cord network unable to generate the rhythmic oscillations normally elicited by application of N‐methyl‐D‐aspartate (NMDA), but in ∼40% of cases chronic incubation in NMDA maintained rhythmic activity. We conclude that there is an autonomous embryonic hindbrain network that is necessary for proper development of the spinal central pattern generator, and that the hindbrain network can partially develop independently of ascending input. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007.
Misdiagnosis of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Introduction: Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) has major implications for the management of patients and their first‐degree relatives. Diagnosis is based on a set of criteria proposed by the International Task Force for Cardiomyopathies. We report our experience in providing a re‐evaluation for patients who previously have been diagnosed with ARVD/C.
Rituximab in Lymphoma with Life Threatening Haemolysis

The efficacy and safety of anti-CD 20 monoclonal antibody (Rituximab) alone and in combination with chemotherapy, has been well established in patients with relapsed and refractory low-grade non-Hodgkin’s lymphoma [1]. Rituximab is a chimeric murine/human monoclonal antibody. It reacts specifically with the Bcell antigen CD20, induces complement-mediated and antibody-dependent cellular cytotoxicity, and directly induces apoptosis [2]. Here we report a case of chemotherapy refractory low grade non-Hodgkin’s lymphoma complicated with life threatening haemolysis treated successfully with Rituximab.
Exposure to 17α‐ethinylestradiol decreases motility and ATP in sperm of male fighting fish Betta splendens

The synthetic estrogen 17α‐ethinylestradiol (EE2) is an endocrine‐disrupting chemical released into aquatic environments from sewage treatment facilities. We tested the effects of two environmentally relevant concentrations of waterborne EE2, 10 and 100 ng L−1, on reproductive endpoints in the teleost fish Betta splendens. In the first experiment, testes were removed from males and sperm were exposed to EE2 directly through the activation water. Direct exposure to EE2 had no effect on any measure of sperm swimming performance. In the second experiment, we exposed sexually mature male B. splendens to EE2 using a semi‐static exposure protocol for 4 weeks. There were no significant treatment effects in the 10 ng L−1 treatment group, but at the 100 ng L−1 dose we found that fish had smaller gonads and reduced sperm swimming velocity. When allowed to interact freely with female conspecifics, males exposed to 100 ng L−1 EE2 built smaller nests and showed a nonsignificant decrease in fertilization success. To investigate further the potential mechanism underlying the decrease in sperm quality, we repeated the chronic exposure experiment and analyzed the ATP content of sperm from fish in each treatment group. We found that males exposed to 100 ng L−1 of EE2 had fewer moles of ATP per sperm than did fish in the other two treatment groups, suggesting that a decrease in intracellular ATP caused a reduction in sperm swimming velocity. The current study adds to the growing body of literature that indicates the risks to aquatic organisms of exposure to environmentally relevant concentrations of EE2. © 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 243–252, 2014.
Disulfide bonds in folding and transport of mouse hepatitis coronavirus glycoproteins

We have analyzed the effects of reducing conditions on the folding of the spike (S) protein and on the intracellular transport of the membrane (M) protein of the mouse hepatitis coronavirus. These proteins differ in their potential to form disulfide bonds in the lumen of the endoplasmic reticulum (ER). Intrachain disulfide bonds are formed in the S protein but not in M, which was demonstrated in a pulse-chase experiment by analyzing the viral proteins under nonreducing conditions. To reduce disulfide bonds in vivo, we added dithiothreitol (DTT) to the culture medium of mouse hepatitis coronavirus-infected cells following a procedure recently described by Braakman et al. (I. Braakman, J. Helenius, and A. Helenius, EMBO J. 11:1717-1722, 1992). Short exposure to DTT resulted in the complete reduction of newly synthesized S protein and affected its conformation as judged by the change in mobility in nonreducing gels and by the loss of recognition by a conformation-specific monoclonal antibody. Using this antibody in an immunofluorescence assay, we monitored the reducing effect of DTT in situ. DTT was found to initially affect only the S protein present in the ER; also, after longer treatment, the remaining signal also gradually disappeared. In contrast, folding and transport of the M protein were not inhibited by DTT. Under reducing conditions, M was transported efficiently to the trans side of the Golgi complex, indicating that cellular processes such as ER-to-Golgi transport, O-glycosylation, and Golgi retention were unaffected. In the presence of DTT, the M protein even moved at an increased rate to the Golgi complex, which is probably because of its failure to interact with unfolded S protein. The effects of in vivo reduction were reversible. When DTT was removed from pulse-labeled cells, the S protein folded posttranslationally and aberrantly; during its oxidation, most of S now transiently aggregated into large disulfide-linked complexes from which subsequently folded S molecules dissociated.
Multilayer microwave diplexers based on dual-mode resonators for ISM/WiFi bands

In this paper, novel multilayer microstrip diplexer is presented for ISM band at 2.45 GHz and WiFi at 3.6 GHz. The receiver and transmitter filters of the diplexer are implemented using square loop dual-mode resonators. First, we propose the planar diplexer realized in one single PCB layer. In that way, the characteristic in both bands can be independently controlled by changing the resonator dimensions. Moreover, several transmission zeros are located at the passband edges resulting in improved passband selectivity. The multilayer modification is proposed as transition from coplanar to microstrip architecture in order to obtain high isolation between filters in different layers. By using the multilayer design the size reduction and wide passbands are achieved with isolation better than 20 dB.
Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase

Asparagine‐linked glycosylation is a highly conserved protein Modification reaction that occurs in all eukaryotes. The initial stage in the biosynthesis of N‐linked glycoproteins, catalyzed by the enzyme oligosaccharyltransferase (OST), involves the transfer of a preassembled high‐mannose oligosaccharide from a dolichol‐linked oligosaccharide donor onto asparagine acceptor sites in nascent proteins in the lumen of the rough endoplasmic reticulum. Biochemical, molecular biological, and genetic studies conducted during the past 5 years have resulted in an explosive growth in our knowl‐edge concerning the OST. Although the basic biochemical properties of the enzyme were determined more than a decade ago using intact microsomal membranes, recent studies provide novel insight into the catalytic mechanism of the enzyme. The OST was recently purified as a large heteroligomeric membrane protein complex; the sequences of many of the subunits have been determined from both fungal and vertebrate sources. Consistent with the evolutionary conservation of N‐linked glycosylation, protein sequence comparisons reveal significant homologies between vertebrate, invertebrate, plant, and fungal OST subunits. Yeast molecular genetic methods have been instrumental in the functional characterization of the OST subunits, and halve proven to be powerful tools for the identification of novel gene products that influence oligosaccharide transfer in vivo. —Sil‐ berstein, S. , Gilmore, R. Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase. FASEB J. 10,849‐858 (1996)
Electromagnetic field distribution in areas surrounded by many wires

In this paper, shielding effects of some enclosures composed with thin wires (wire arrays) are studied. For examples, the thin wire arrays lined on a circle making a tube are analyzed to evaluate the shielding effectiveness as well as the field distributions in and around the structure. The near fields formed by the wire system that includes an active wire or a wire driven by an external power source are shown.
Coordination support for integrating user centered design in distributed agile projects

Agile process and User Centered Design (UCD) approach are two fields with high beneficial opportunities when integrated together. Both are based on minimal design up front and frequent feedback from users, and both are human-centered. However, one of the main concerns in integrating them is how to coordinate the work properly specially in distributed projects. The traditional methods used (e.g. video conferencing) do not provide full support to involve the UX-designers during the daily project activities. UX-designers may struggle to know if their design is technically applicable which makes it necessary for developers to review the designs from their perspective. Similarly, developers need instant answers from UX-designers during and after developing the work items. Furthermore, the review of thirty agile management tools that support the integration of UCD into agile projects, reveals a lack of computer-based support for the development teams and UX-design teams. This paper aims to identify the situations in which UX-designers and developers require proper coordination mechanisms. This research identified 14 UCD-related activities that require further coordination support. A questionnaire was conducted for the evaluation. The results show that the integration of UCD activities in distributed agile environments still needs coordination especially between the UX-design team and the development team. The result is important because it can help in overcoming the limitations of the informal and formal approaches, support managing the UCD activities in distributed agile environments and facilitating the coordination of the work between developers and UX-designers.
Peak Vertical Jump Power as a Marker of Bone Health in Children

Abstract The objective of this investigation was to evaluate the accuracy of peak vertical jump power (VJP) to identify children with bone mineral density (BMD) below average, defined as BMD measured by DXA and adjusted for body height at the whole body less head≤− 1.0 standard deviation (SD). The sample included 114 boys and girls aged 8.5±0.4 years old. VJP was estimated from a countermovement jump performed on a contact mat using the measured flight time to calculate the height of rise of the center of gravity. Logistic regression analysis revealed that the odds ratio of having BMD≤1.0 SD decreased 1.2% per watt of power and the probability of BMD below average was 75.6% higher in boys than in girls with the same peak power jump. Receiver operating characteristic analysis showed that the best trade-off between sensitivity and specificity to identify children with BMD<− 1.0 SD was 635 watts in boys (sensitivity=63.3%; specificity=69.2%; AUC=0.816, 95% CI: 0.681–0.95; p<0.001) and 515 watts in girls (sensitivity=75.0%; specificity=77.0%; AUC=0.849, 95% CI: 0.698–0.999; p=0.002). These cut-off values correspond to a vertical jump of 19.9 cm and 20.5 cm in 8-year-old boys and girls, respectively. The VJP showed a reasonable sensitivity and specificity as well good discriminant ability to identify children with BMD below average.
Identification of Cell Surface Molecules Characterizing Human Cutaneous T-cell Lymphomas

Primary cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of malignant mature T-cell proliferations most often presenting as mycosis fungoides (MF) or its leukemic variant, Sezary syndrome (SS). No specific cell surface markers are presently available to distinguish the circulating malignant clone from normal lymphocytes. Using the previously established CTCL cell lines, Cou-LS and Pno, we have detected two leucocyte cell surface antigens with aberrant expression on CTCL cells. The NK-receptor (NKR) p140/KIR3DL2 normally expressed by NK and CD8+ T-cells was detected on the surface of CTCL cell lines as well as on freshly isolated CD4+PBL from SS patients. Further on, p140 marked in situ SS cells, distinguishing them from p140-negative tumor cells of patch plaque MF. SC5 is a newly described activation-related intracellular inhibitory receptor expressed on the surface of a minor PBL subset. We found that SC5 expression was significantly increased in SS cells and correlated to p140 expression. Moreover, cross-linking of SC5 molecules inhibited the malignant cell proliferation induced by anti-CD3 mAbs. The identification of these new structures on circulating SS tumor cells seems to be important both for the understanding of CTCL pathophysiology and for the clinical management of SS patients.
Wind power bidding strategy in a day-ahead electricity market

This paper proposes a stochastic model for optimal bidding of wind power in a day-ahead electricity market. The uncertainties due to wind power generation and market prices are characterized by first carrying out the point forecasts through advanced statistical methods and then, the probable scenarios are generated using Kernal density estimation. The effectiveness of the proposed approach is tested on wind power producers in the area DK2 of Nord pool electricity market. Two year (2011 and 2012) market prices are considered for analysis. The test results are compared with respect to the revenues generated by point forecast, stochastic optimization and perfect prediction based bidding methods.
Heterogeneity of Pituitary Folliculo‐Stellate Cells: Implications for Interleukin‐6 Production and Accessory Function in vitro

The population of folliculo‐stellate (FS) cells of the rat anterior pituitary has been shown to be ultrastructurally and immunohistochemically heterogeneous. Based on the overlap of ultrastructural characteristics, the localization in the anterior pituitary and the co‐expression within the same cel of the S‐100 protein (a marker for FS cells) and MHC‐class II determinants (an immune marker) we concluded that a partial overlap exists between the population of FS cells and the monocyte‐derived dendritic cells (DC). In this report we describe that interleukin‐6 (IL‐6) immunoreactivity was found in situ in stellate cells of the rat, mouse and human anterior pituitary at a very low density (<1% of the cells); the topography was reminiscent of the distribution of FS cells. In the present study we also analyse three different pituitary cell separation methods, in order to study the functional heterogeneity of the FS cells in vitro, and to verify whether functionally distinct subpopulations exist within the FS cell group.
Isolation of influenza A/H3 and B viruses from an influenza patient: confirmation of co-infection by two influenza viruses.

Influenza A/H3 and B viruses co-circulated in the 2004 2005 epidemic season in Japan, and we confirmed a case of co-infection by both viruses. The two influenza viruses were isolated from a single patient by the plaque purification technique, and co-infection was confirmed. The patient was a 4-year-old girl whose throat swab specimens were positive for both influenza A and B viruses by a quick diagnostic agent. The virus was isolated from the throat swab by inoculation onto Madin-Darby canine kidney (MDCK) cells. The first culture sample (MDCK1) responded to B/Johannesburg/5/99 antiserum in a hemagglutination inhibition (HI) test using antisera provided by the National Institute of Infectious Diseases (NIID), Tokyo (Table 1). HA genes of both influenza A/H3 and B viruses were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in the first culture sample. These results suggest that the A/H3 and B influenza viruses co-existed in sample MDCK1. Virus cloning was performed by plaque purification after neutralization with each antiserum (Fig. 1). The influenza A/H3 and B viruses were cloned. The influenza A/H3 virus responded only to A/Wyoming/03/2003 antiserum, and the B virus responded to B/Johannesburg/5/99 antiserum. Thus, we conclude that this patient was co-infected with A/Wyoming/03/ 2003-like and B/Johannesburg/5/99-like influenza viruses. In another possible case of co-infection, a 9-year-old girl was diagnosed with influenza at a sentinel surveillance clinic by a rapid antigen detection kit which gave a positive result for influenza A virus but did not test for influenza B virus. The patient’s throat swab specimen was inoculated onto MDCK cells and the first culture sample was tested by HI assay. The virus did not respond to any of the tested antisera (data not shown), however, HA genes of both influenza A/H3 and B viruses were detected by RT-PCR in the virus sample. Unfortunately, plaque cloning of the influenza viruses was not performed in this case. It is generally believed that co-infection by two influenza viruses is a rare event. In the present study, we confirmed a case of co-infection in a patient who visited her local clinic during the peak period of epidemic caused by influenza A/H3 and B viruses. Although there was also a second case of suspected co-infection with influenza A and B viruses, the first culture sample did not respond to any of the tested antisera in an HI assay. Paired serum samples were not available from these two cases and it was not possible to serologically confirm co-infection. The present study demonstrates the possibility of co-infection by different types of influenza viruses when an epidemic is caused by multiple types of influenza viruses.
Reinforcement learning algorithm based on immune tolerance

A novel reinforcement learning algorithm, which employs an intelligent mechanism called artificial immune tolerance process, is proposed for problems of the trap into a local extremum and the divergence of the state values when introducing the value function approximation in reinforcement learning, and also for reducing the learning factor's influence on the whole processing. This algorithm adjusts the weights with TD(λ) from the function of immune tolerance. During the learning process, weights control the state values based on function approximation. When the error is greater than a certain threshold, the system uses immune tolerance to optimize the weights. Otherwise, the system selects the best strategy according to the situation. After performance analyses and simulations, the results show that the new algorithm can have smaller errors, faster global search, greater diversity, and less influence of the learning factors.