Miracle-dz/UniFAR-FTUs huggingface dataset:
Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma

ABSTRACT Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b in tumor tissues was negatively correlated with their expression level. GCA patients in stage III and IV with reduced expression or hypermethylation of miR-203a demonstrated poor patient survival. In all, miR-203a and miR-203b may function as tumor suppressive miRNAs, and reactivation of miR-203a may have therapeutic potential and may be used as prognostic marker for GCA patients.
Association analysis of the PIP4K2A gene on chromosome 10p12 and schizophrenia in the Irish study of high density schizophrenia families (ISHDSF) and the Irish case–control study of schizophrenia (ICCSS)

Molecular studies support pharmacological evidence that phosphoinositide signaling is perturbed in schizophrenia and bipolar disorder. The phosphatidylinositol‐4‐phosphate‐5‐kinase type‐II alpha (PIP4K2A) gene is located on chromosome 10p12. This region has been implicated in both diseases by linkage, and PIP4K2A directly by association. Given linkage evidence in the Irish Study of High Density Schizophrenia Families (ISHDSF) to a region including 10p12, we performed an association study between genetic variants at PIP4K2A and disease. No association was detected through single‐marker or haplotype analysis of the whole sample. However, stratification into families positive and negative for the ISHDSF schizophrenia high‐risk haplotype (HRH) in the DTNBP1 gene and re‐analysis for linkage showed reduced amplitude of the 10p12 linkage peak in the DTNBP1 HRH positive families. Association analysis of the stratified sample showed a trend toward association of PIP4K2A SNPs rs1417374 and rs1409395 with schizophrenia in the DTNBP1 HRH positive families. Despite this apparent paradox, our data may therefore suggest involvement of PIP4K2A in schizophrenia in those families for whom genetic variation in DTNBP1 appears also to be a risk factor. This trend appears to arise from under‐transmission of common alleles to female cases. Follow‐up association analysis in a large Irish schizophrenia case–control sample (ICCSS) showed significant association with disease of a haplotype comprising these same SNPs rs1417374–rs1409395, again more so in affected females, and in cases with negative family history of the disease. This study supports a minor role for PIP4K2A in schizophrenia etiology in the Irish population. © 2009 Wiley‐Liss, Inc.
Cognitive networks

This paper presents a definition and framework for a novel type of adaptive data network: the cognitive network. In a cognitive network, the collection of elements that make up the network observes network conditions and then, using prior knowledge gained from previous interactions with the network, plans, decides and acts on this information. Cognitive networks are different from other "intelligent" communication technologies because these actions are taken with respect to the end-to-end goals of a data flow. In addition to the cognitive aspects of the network, a specification language is needed to translate the user's end-to-end goals into a form understandable by the cognitive process. The cognitive network also depends on a software adaptable network that has both an external interface accessible to the cognitive network and network status sensors. These devices are used to provide control and feedback. The paper concludes by presenting a simple case study to illustrate a cognitive network and its framework
Regulation of Replicon Size in Xenopus Egg Extracts

Once a specific number of cells have been produced in the early Xenopus laevis embryo, replicon size during the S phase of the cell cycle increases. Here, it is reported that similar increase in replicon size occurred when the concentration of nuclei in replication-competent Xenopus egg extracts exceeded a critical threshold. In this system, the origin recognition complex (ORC) did not become stoichiometrically limiting for initiation, and similar amounts of this complex bound to chromatin regardless of replicon size. These data suggest that in early development, an unidentified factor controls how many preformed ORC-DNA complexes initiate DNA replication.
Más allá del molesto ronquido: síndrome de apnea obstructiva del sueño y su peligrosa asociación con el síndrome metabólico

El sindrome de apnea hipoapnea obstructiva del sueno (SAHOS) es una enfermedad frecuente que afecta alrededor del 5 % de la poblacion general y a casi la mitad de los pacientes obesos. La asociacion de SAHOS con obesidad ha sido bien establecida desde que fue descrito por primera vez; durante los ultimos anos ha sido creciente la produccion literaria que asocia la hipoxemia con un incremento de la enfermedad cardiovascular y metabolica, las cuales finalmente originan un mayor riesgo cardiovascular en los pacientes afectados no necesariamente obesos. Debido a la presencia de hipoxemia secundaria a la obstruccion mecanica del flujo aereo que se encuentra en los pacientes afectados por el sindrome de apnea hipoapnea obstructiva del sueno, se desencadenan eventos fisiopatogenicos tales como la liberacion de radicales libres, la disminucion de la expresion de algunas enzimas importantes para el clivaje del colesterol y la produccion de oxido nitrico y el aumento en la produccion de mediadores inflamatorios que generan disrupcion de vias metabolicas y endocrinologicas, lo cual ocasiona un incremento en el riesgo de sufrir diabetes mellitus, resistencia a la insulina, hipertension arterial, obesidad y dislipidemia aterogenica.
The Parametrization of Canal Surfaces and the Decomposition of Polynomials into a Sum of Two Squares

A canal surface in R3, generated by a parametrized curveC=m(t), is the Zariski closure of the envelope of the set of spheres with radius r(t) centered at m(t). This concept is a generalization of the classical notion of an offsets of a plane curve: first, the canal surface is a surface in 3-space rather than a curve inR2 and second, the radius function r(t) is allowed to vary with the parametert . In case r(t) =const, the resulting envelope is called a pipe surface. In this paper we develop an elementary symbolic method for generating rational parametrizations of canal surfaces generated by rational curves m(t) with rational radius variation r(t). This method leads to the problem of decomposing a polynomial into a sum of two squares over R. We discuss decomposition algorithms which give symbolic and numerical answers to this problem.
Influence of CYP3A5 and MDR1 Genetic Polymorphisms on Urinary 6β‐Hydroxycortisol/Cortisol Ratio After Grapefruit Juice Intake in Healthy Chinese

Interindividual variability of cytochrome P450 (CYP) 3A inhibition by grapefruit juice was investigated in relation to CYP3A5 and multidrug resistance gene (MDR) 1 genetic polymorphisms in Chinese Han, Uygur, and Kazakh healthy subjects. The measurement of urinary 6β‐hydroxycortisol/cortisol ratio was used to evaluate CYP3A activity in vivo by high‐performance liquid chromatography. CYP3A5*3 and MDR1 C1236T, G2677T/A, and C3435T polymorphisms were analyzed by polymerase chain reaction restriction fragment length polymorphism. After grapefruit juice intake, urinary ratios significantly decreased in 3 Chinese ethnic groups (P < .001). Kazakh had a larger decrease of urinary ratio compared to that of Han (P < .05), and the latter had similar decrease with Uygur. Furthermore, Chinese healthy subjects carrying CYP3A5*3/*3 and MDR11236‐2677‐3435 T‐T‐T/T‐T‐T genotypes were found to have the largest reduction of urinary ratio (mean, 61.4%; 95% confidence interval, 53.4%‐69.5%), whereas *1/*3 subjects carrying MDR11236‐2677‐3435 C‐G‐C/C‐G‐C genotypes had the lowest reduction (mean, 25.9%; 95% confidence interval, 3.1%‐48.8%; P < .01). In conclusion, both CYP3A5*3 and MDR1 variants influenced the extent of CYP3A inhibition by grapefruit juice in Chinese healthy subjects. The genetic variations influencing the CYP3A inhibitive phenotype might be helpful to explain the individual variability of grapefruit juice—drug interactions.
Physical activity modulates the effect of a lipoprotein lipase mutation (D9N) on plasma lipids and lipoproteins

We investigated interactions between a mutation (D9N) in the lipoprotein lipase (LPL) gene and physical activity, as well as other lifestyle factors, on lipid traits in a population‐based sample of Dutch men and women (n=379). We used questionnaire information to classify physical activity, alcohol consumption, and smoking habits, while overweight was defined as a body mass index (BMI)> 25 kg/m2. Non‐fasting blood samples were used for the determination of lipid traits and the D9N genotype. Fifteen subjects (4%) carried the mutation. They presented with higher levels of total cholesterol, apolipoprotein (apo) B and triglycerides compared to non‐carriers. While no interactions with overweight, alcohol consumption, and smoking were found, a strong interaction between the D9N mutation and physical activity became apparent. Physically inactive D9N carriers (n=5) had considerably higher total cholesterol (+2 mmol/l, p≤0.0001) and apo B levels (+63 mg/dl, p≤0.0001) compared to non‐carriers of this mutation, whereas their high‐density lipoprotein (HDL)‐cholesterol concentrations were lower (−0.22 mmol/l, p<0.05). This was not the case for physically active D9N carriers (n=10).
Self-Scaled Barriers and Interior-Point Methods for Convex Programming

This paper provides a theoretical foundation for efficient interior-point algorithms for convex programming problems expressed in conic form, when the cone and its associated barrier are self-scaled. For such problems we devise long-step and symmetric primal-dual methods. Because of the special properties of these cones and barriers, our algorithms can take steps that go typically a large fraction of the way to the boundary of the feasible region, rather than being confined to a ball of unit radius in the local norm defined by the Hessian of the barrier.
Etiologic Factors in Lead Nephropathy

The rare occurrence of lead nephropathy in widely differing circumstances has suggested that additional causative factors might be required for its production. Seventeen cases of interstitial nephritis associated with severe chronic lead poisoning were reviewed in an attempt to identify these. Data suggested that alcoholism and preexistent hypertension, and also previous or minor urinary tract disease, may potentiate the injurious effects of lead. We recommend that the diagnosis of lead nephropathy should be a positive one, ndt one of exclusion, and that stored lead should be removed, particularly in persons with hypertension or previous urinary tract disease.
A review of epidemiologic studies of triazine herbicides and cancer

This is an update of a previous review of epidemiological evidence pertaining to the human carcinogenic potential of triazine herbicides. In 36 studies evaluated, atrazine was the most common triazine investigated. In general the studies were limited by lack of in-depth exposure measurements and by small numbers of subjects with potential high exposure and/or with many years of follow-up since first exposure. Non-Hodgkin lymphoma, prostate cancer, and breast cancer were most frequently investigated. Only one to three analytical or ecological studies investigated Hodgkin lymphoma, leukemia, multiple myeloma, soft tissue sarcoma, hairy-cell leukemia, melanoma, and cancers of the ovary, testes, colon, stomach, lung, brain, bladder, buccal cavity, and pharynx. Results of these studies were typically imprecise and did not form an adequate basis for determining if triazine exposure causes any form of cancer. Collectively, the available epidemiology studies do not provide consistent, scientifically convincing evidence of a causal relationship between exposure to atrazine or triazine herbicides and cancer in humans. Based upon the assessment studies, there is no scientific basis for inferring the existence of a causal relationship between triazine exposure and the occurrence of cancer in humans.
The white Gene of Drosophila melanogaster Encodes a Protein with a Role in Courtship Behavior

The white gene of Drosophila melanogaster has been extensively studied, yet it is still not understood how its ectopic overexpression induces male-male courtship. To investigate the cellular basis of this behavior, we examined the sexual behavior of several classes of mutants. We find that male-male courtship is seen not only in flies overexpressing the white gene, but also in mutants expected to have mislocalized White protein. This finding confirms that mislocalizing White transporter in the cells in which it is normally expressed will produce male-male courtship behaviors; the courtship behavior is not an indirect consequence of aberrant physiological changes elsewhere in the body. Male-male courtship is also seen in some mutants with altered monoamine metabolism and deficits in learning and memory, but can be distinguished from that produced by White mislocalization by its reduced intensity and locomotor activity. Double mutants overexpressing white and with mutations in genes for serotonergic neurons suggest that male-male courtship produced by mislocalizing White may not be mediated exclusively by serotonergic neurons. We also find decreased olfactory learning in white mutants and in individuals with mutations in the genes for White's binding partners, brown and scarlet. Finally, in cultured Drosophila and mammalian cells, the White transporter is found in the endosomal compartment. The additional genes identified here as being involved in male-male courtship increase the repertoire of mutations available to study sexual behavior in Drosophila.
Illumination invariant face recognition based on dual-tree complex wavelet transform

This study presents a new dual-tree complex wavelet transform (DT-CWT)-based illumination normalisation approach for face recognition under varying lighting conditions. The method consists of three steps. First, the DT-CWT-based edge detection method is proposed which can obtain estimation for facial feature edges in different directionality and resolution level. Second, the DT-CWT-based denoising model is employed to obtain the multi-scale illumination invariant structures in the logarithm domain. Finally, by combining the obtained illumination invariant features and edge estimation information, the enhanced facial features are obtained which have more discriminating power for variable lighting face recognition. The effectiveness of the method is validated in comparative performance against many classical illumination compensation methods using the YaleB database and the CMU PIE database.
Love deprivation in children: analysis of cultural variables depriving children of parental love and its repercussions on children's future lives

This study was designed to assess to what extent children and their caregivers understand the significance of parental deprivation and to what extent they share an awareness of the levels of deprivation children face. Cross sectional survey was carried out to gather data regarding parental love deprivation in children and its likely repercussions on their future lives. Multi stage sampling was employed in which 100 children aged 4 -12 were randomly selected to gauge love and affection they receive from their parents and also researched a random sample of 100 adults of varying age groups (30-65) to correlate love deprivation with different facets of their lives. Study was based on Rawalpindi as urban centre and five remote villages of Namal Valley in Mianwali District. Study revealed interesting results. Parents’ income, education, and rural/urban origin came out as important factors in determining parental love towards their children. The results of study concluded that love deprivation syndrome amongst children in Pakistan is falling with an average of around 2 per cent per annum. Love deprivation is found to be more prevalent in uneducated, low income and rural segment of Pakistani society
A prototype for solving conflicts in XACML-based e-Health policies

The Electronic Patient Record (EPR) enables the sharing of medical documents among several and widespread healthcare organizations. To guarantee privacy properties, access control policies should be defined, regulating how the documents can be shared. Conflicts may occur among policies applicable to the same access request. We present a running prototype, based on an XACML engine, that implements a conflict resolution strategy as an extension to the standard combining algorithms of the XACML engine. We evaluate the efficiency of our proposal in terms of execution time, on a variable number of conflicting rules.
Changes in gene expression of individual matrix metalloproteinases differ in response to mechanical unloading of tendon fascicles in explant culture

Immobilization of the tendon and ligament has been shown to result in a rapid and significant decrease in material properties. It has been proposed that tissue degradation leading to tendon rupture or pain in humans may also be linked to mechanical unloading following focal tendon injury. Hence, understanding the remodeling mechanism associated with mechanical unloading has relevance for the human conditions of immobilization (e.g., casting), delayed repair of tendon ruptures, and potentially overuse injuries as well. This is the first study to investigate the time course of gene expression changes associated with tissue harvest and mechanical unloading culture in an explant model. Rat tail tendon fascicles were harvested and placed in culture unloaded for up to 48 h and then evaluated using qRT‐PCR for changes in two anabolic and four catabolic genes at 12 time points. Our data demonstrates that Type I Collagen, Decorin, Cathepsin K, and MMP2 gene expression are relatively insensitive to unloaded culture conditions. However, changes in both MMP3 and MMP13 gene expression are rapid, dramatic, sustained, and changing during at least the first 48 h of unloaded culture. This data will help to further elucidate the mechanism for the loss of mechanical properties associated with mechanical unloading in tendon. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:1306–1312, 2008
Development of Systemic Lupus Erythematosus Following Interferon-α Therapy for Hepatitis C Infection.

Interferon-alpha (IFN-α) therapy has been associated with de novo development of systemic lupus erythematosus (SLE). We report a 48-year woman with chronic hepatitis C, who developed low grade fever, joint aches and pains, painful mouth ulcers, shortness of breath, dry cough and pleuritic chest pain after 2 months of completion of treatment with pegylated interferon-alpha. These clinical manifestations and the relevant immunologic investigations were in favour of SLE. She responded well to corticosteroids and hydroxychloroquine treatment.
A REVIEW ON THE REMOTE SENSING IMAGES BASED ON OBJECT DETECTION USING DEEP BELIEF NETWORKS

This paper represents the object detection which has been one of the hottest issues in the field of remote sensing image analysis. It is of vital importance for object dynamic surveillance and other applications. So far, object detection has been widely researched. It shows an efficient coarse object locating method based on a saliency mechanism. The method could avoid an exhaustive search across the image and generate a small number of bounding boxes. After that, the trained DBN is used for feature extraction and classification on sub-images. The general purpose of this document is actually to research the a variety of strategies based on object detection and it also demonstrate the accuracy and efficiency of object detection framework using a saliency prior and DBNs for remote sensing images. Keywords— Image segmentation, Object detection, Deep belief networks, Saliency.
RICE BRAN AND ITS MAIN COMPONENTS: POTENTIAL ROLE IN THE MANAGEMENT OF CORONARY RISK FACTORS

The prevention of cardiovascular disease events is related to a complex management of conventional and non-conventional risk factors. The first approach to reduce the cardiovascular disease risk is a correct dietary approach. Rice bran and its main components (Fibres, unsaturated fatty acids, triterpene alcohols, phytosterols, tocotrienols, alpha-tocopherol) have demonstrated their property to improve the plasma lipid pattern of rodents, rabbits, non-human primates and humans, reducing total plasma cholesterol and triglyceride concentration and increasing the high density lipoprotein cholesterol level. Other potential properties of rice bran components have been studied both in vitro and in animal models such as modulation of the pituitary secretion, inhibition of the gastric acid secretion, antioxidant action and inhibition of the platelet aggregation. The main aim of this paper is to review the available data on pharmacology and toxicology of rice bran and its main components with a particular attention to those data suggesting a potential efficacy in reducing the cardiovascular disease risk.
PERIPHERAL CIRCULATORY RESPONSE TO PHOTOTHERAPY IN NEWBORN INFANTS

Calf blood flow (CBF), calf skin temperature, incubator wall and ambient temperature, and respiratory rate, were measured in 8 newborn infants 10 to 127 hours of age, who were treated by phototherapy because of jaundice. During phototherapy (within 30 min) the CBF increased to a range of 30 to 80% above the control values of 8.8 ± 0.9 ml/min/100 g. The CBF is correlated directly with the leg skin temperature (γ= 0.724 and 0.588 at 15 and 30 min after phototherapy respectively). The increase in CBF was associated with a fall in incubator ambient temperature, the latter is a result of the use of servo control unit in monitoring incubator temperature by epigastric skin temperature. The increase in CBF is probably evidence of peripheral vasodilatation to facilitate evaporative heat loss. An increase in respiratory rate was also observed during phototherapy. The observed increase in heat loss (and water loss) from vasodilatation and increased respiratory rate serve as a basis for the increase in insensible water loss as previously reported.
Persistence of contamination of hens' egg albumen in vitro with Salmonella serotypes

SUMMARY A study was made of the persistence of different Salmonella serotypes in hens' egg albumen in vitro at 4, 20 and 30 °C. The majority of serotypes remained viable but did not increase in numbers at 20 and 30 °C for 42 days. At 4 °C many of the serotypes died out. The addition of ferric ammonium citrate on the 42nd day of incubation induced multiplication of organisms incubated at 20 and 30 °C, but not at 4 °C. The pH and glucose concentration of the albumen diminished only when heavy growth occurred. Salmonella enteritidis remained viable on the air cell membrane in vitro for 17 days at 4, 20 and 30 °C. Thirty percent of the organisms also remained motile in albumen for 42 days at 25 °C and up to 5% of the cells remained motile for up to 20 days at 4 °C.