Miracle-dz/UniFAR-FTUs huggingface dataset:
Comportamiento in vitro de células stem mesénquimales de origen dental humano en matrices extracelulares tridimensionales de ácido poliláctico/poliglicólico con y sin hidroxiapatita

En la ingenieria de tejidos oseos es fundamental estudiar el sinergismo entre las celulas stem mesenquimales y el biomaterial para poder tener un mayor control de las respuestas y funcion celular, por esto las respuestas celulares relacionadas con los procesos de proliferacion, adhesion y diferenciacion en matrices extracelulares tridimensionales deben ser estudiadas en diferentes biomateriales. OBJETIVO: El proposito de este estudio fue analizar el comportamiento in vitro de las celulas stem mesenquimales de pulpa dental humana (hDPSCs) cultivadas en matrices extracelulares tridimensionales de acido polilactico/poliglicolico (PLGA) con y sin hidroxiapatita (HA). METODO: Estudio experimental in vitro. Se cultivaron hDPSCs en dos tipos de matrices (PLGA/HA y PLGA) con medio de diferenciacion osteogenica STEMPRO® y se evaluo la proliferacion, adhesion y diferenciacion celular a linaje osteoblastico en tres tiempo diferentes; 7, 15 y 30 dias. Cada experimento se realizo por triplicado. El analisis de los datos obtenidos se realizo con el modelo estadistico Split Plot en bloque y Manova para datos semiparametricos. Posteriormente, se realizo un estudio piloto en modelo animal lagomorfo para evaluar la regeneracion osea a nivel clinico e histologico RESULTADOS: La proliferacion y diferenciacion a linaje osteoblastico de las hDPSCs se incremento en la matriz de PLGA/HA a los 7, 15 y 30 dias, no se observaron diferencias estadisticamente significativas en la adhesion entre los dos tipos de matrices. Se observo un menor tiempo en la regeneracion de lesiones oseas de tamano critico in vivo con las hDPSCs en la matrices de PLGA/HA. CONCLUSION: El comportamiento in vitro de las hDPSCs en los dos tipos de constructos fue significativamente diferente, probablemente los constructos de PLGA/HA proporcionan mejores senales fisicas y quimicas, lo que podria explicar una mejor proliferacion y diferenciacion celular a linaje osteoblastico.
Context-dependency in the Cognitive Bias Task and Resting-state Functional Connectivity of the Dorsolateral Prefrontal Cortex

Abstract Objective: Goldberg, the author of the “novelty-routinization” framework, suggested a new pair of cognitive styles for agent-centered decision-making (DM), context-dependency/independency (CD/CI), quantified by the Cognitive Bias Task (CBT) and supposedly reflecting functional brain hemispheric specialization. To date, there are only three lesion and activation neuroimaging studies on the CBT with the largest sample of 12 participants. The present study is the first to analyze whole-brain functional connectivity (FC) of the dorsolateral prefrontal cortex (DLPFC), involved in contextual agent-centered DM. Method: We compared whole-brain resting-state FC of the DLPFC between CD (n = 24) and CI (n = 22) healthy participants. Additionally, we investigated associations between CD/CI and different aspects of executive functions. Results: CD participants had stronger positive FC of the DLPFC with motor and visual regions; FC of the left DLPFC was more extensive. CI participants had stronger positive FC of the left DLPFC with right prefrontal and parietal-occipital areas and of the left and right DLPFC with ipsilateral cerebellar hemispheres. No sex differences were found. CD/CI had nonlinear associations with working memory. Conclusions: The findings suggest that CD and CI are associated with different patterns of DLPFC FC. While CD is associated with FC between DLPFC and areas presumably involved in storing representations of current situation, CI is more likely to be associated with FC between DLPFC and right-lateralized associative regions, probably involved in the inhibition of the CD response and switching from processing of incoming perceptual information to creation of original response strategies.
Efficacy and safety of recombinant human epidermal growth factor for diabetic foot ulcers: A systematic review and meta‐analysis of randomised controlled trials

To evaluate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) in treating diabetic foot ulcers (DFUs), we conducted both database searches (PubMed, MEDLINE, EMBASE, CENTRAL, and Web of Science) and reference searches for randomised controlled trials from the inception of databases to 30 January 2020. Two reviewers independently scrutinised the trials, extracted data, and assessed the quality of trials. The primary outcome was the proportion of complete healing. The secondary outcomes were mean time to complete healing and adverse events. A subgroup analysis was performed by different administration routes. Statistical analyses were performed in RevMan 5.3. The time to complete healing Kaplan‐Meier curves was pooled in the R software. Of the 156 citations, 9 trials (720 participants) met eligibility criteria and were included. The rhEGF achieved a higher complete healing rate than placebo (OR: 2.79, [95% CI: 1.99, 3.99]). The rhEGF also significantly shorten complete healing time (MD: −14.10 days, [95% CI: −18.03, −10.16]). Subgroup analysis showed that topical application was superior to intralesional injection, but that may be because of different ulcer severity they included. No significant difference was shown in adverse events. Results were coherent with sensitivity analyses. Therefore, rhEGF is an effective and safe treatment for DFUs.
Vivência da sexualidade de jovens antes e após o diagnóstico da infecção pelo HIV

This is a qualitative exploratory research carried out at the Florianópolis AIDS Prevention Support Group from November 2018 to February 2019, in order to know the experience of young people's sexuality before and after the diagnosis of infection by HIV. To carry out the study were interviewed people who had the diagnosis of HIV infection among 18 to 24 years, due to sexual contamination. For data collection, the semi-structured interview was used. Data analysis was performed using Lefevre and Lefévre Collective Subject Discourse methodology. As a result, it was found that young people initiate sexual life in adolescence, with unplanned sexual practices with large numbers of partners and inconsistent use of condoms. The diagnosis of HIV infection occurred on average four years after sexual initiation, with a negative impact on the existence and
Assessing the Diversity of Pythium species and Fungicide Efficacy in Agronomic Production Fields in Ohio

The occurrence of seedling diseases in soybean fields in Ohio has increased over the past decade. There are at least 22 possible species of Pythium that are pathogenic to soybean. During the spring of 2008, field plots were planted at five different locations across the soybean production regions in Ohio, in a randomized block design with eight different fungicide seed treatments and four replications. The fungicide seed treatments included; mefenoxam, fludioxonil, azoxystrobin, mefenoxam + fludioxonil, mefenoxam + azoxystrobin, fludioxonil + azoxystrobin, and mefenoxam + fludioxonil + azoxystrobin. Stand counts at R1 and yield were recorded. Pythium species were isolated from symptomatic plants at these locations and the isolates were then identified to species using single strand conformation polymorphism. There were no significant interactions between location and seed treatment for stand count. Stands from seed treated with azoxystrobin, mefenoxam + fludioxonil, fludioxonil + azoxystrobin, and mefenoxam + fludioxonil + azoxystrobin treatments were significantly higher than the untreated check for stand count, but not for yield. A total of 13 Pythium species were recovered from symptomatic plants from the five locations. Pythium irregulare, P. dissotocum, and P. torulosum were the most frequently recovered species from all five locations. The results from this study will be used for the development of disease management strategies for seedling pathogens in Ohio.
Geothermal energy and support schemes in The Netherlands

The Dutch government intends to stimulate the development of geothermal energy by opening support schemes. Three schemes are installed: investment, guarantee/insurance and exploitation subsidy schemes. The support schemes attracted a relatively large number of applications and can be regarded as successful instruments for the development of geothermal energy. The investment subsidy was granted to proposed innovative energy concepts in the horticultural sector. Application of geothermal energy for the heating of greenhouses was such an innovative investment. The guarantee scheme is an insurance system for the geological risk: the underperformance of a doublet with respect to the pre-drill P90 geothermal power estimate due to disappointing aquifer characteristics. The exploitation scheme (SDE+) is a subsidy on produced geothermal heat to level the difference between conventional heat cost price and the cost price of geothermal heat. All projects in the guarantee scheme and most projects in the exploitation scheme are granted on a pre-drill estimate of the geothermal power to be realised. This implies that the schemes have to deal with large predrill uncertainties, predominantly in the estimated geothermal power. Both schemes use a dedicated software package to estimate the indicative geothermal power, including the uncertainty range. Based on the outcome of this program, the guarantee scheme insures the P90 geothermal power. The SDE scheme makes a budget reservation for the future subsidy (feed-in premium) required for the geothermal energy produced over a 15 year production time. This future subsidy reservation is based on the calculated P50 geothermal power. The subsidy amount is calculated by subtracting the conventional heat cost price from the cost price for generating geothermal heat. The calculation of the cost price of geothermal heat is done using reference projects with an estimated cost structure and heat produced.
Surgical experience in treatment of achalasia cardia with minimal invasive surgery

Background: achalasia cardia is a motor disorder that result from absence of esophageal peristalsis combined with loss of relaxation of lower esophageal sphincter. Aims: To analyze the safety of laparoscopic Heller's myotomy with particular regard to the technical difficulties encountered, complications, the learning curve and outcome. Patients and methods: This study was done at Al Sader Teaching Hospital, Basrah Iraq in the period from February 2013 to June 2016. Thirty-two patients were included in the study of both gender and of different ages who were subjected to laparoscopic Heller's myotomy for achlasia cardia. They were observed regarding the development of operative and early post-operative complications, improvement of their symptoms, development of late post-operative complications and recurrence rate. Results: All patients underwent laparoscopic Heller's myotomy with Dor fundoplication except one patient had Toupet fundoplication. The mean operative time was 87 minutes and the median hospital stay was four days. Intraoperative complications include mucosal perforation in 3 patients, vagus nerve injury in 3 patients, and pleural perforation in 2 patients. Post-operative complications include atelectasis in 3 patients, pneumonia in 1 patient, GERD in 1 patient, post-operative leak in one patient and mortality in one patient. All patients improved regarding dysphagia (100%) and weight gain achieved in (91.3%), chest pain improved in (59%) and regurgitation improved in (84.6%) of the patients. Conclusion: Laparoscopic Heller's myotomy is safe and effective method for treatment of achalasia cardia.
Genetic basis of sex determination in the haplodiploid wasp Nasonia vitripennis

In all examined insects thus far, sex is determined by a cascade of genes with doublesex (dsx) at the bottom of the cascade and transformer (tra) directly upstream of dsx. Both dsx and tra are sex specifically spliced, but only the female specific splice variant of tra yields a functional protein. In all studied insects, except for Drosophila, tra is maternally provided to eggs and initiates and maintains the female specific splicing of its own transcript via an autoregulatory loop. In Nasonia vitripennis this mechanism of sex determination is also conserved and the maternal provision and autoregulation of N. vitripennis tra (Nvtra) have been demonstrated. Here we present the expression dynamics of Nvtra during early embryonic development in embryos from fertilized and unfertilized eggs. We show that in embryos from fertilized eggs the expression of Nvtra is significantly higher than in embryos from unfertilized eggs. We suggest that this difference in expression is caused by maternal imprinting of the Nvtra gene or a trans acting gene. Therefore, males develop as a result of maternal imprinting that prevents zygotic transcription of the maternally derived Nvtra allele in unfertilized eggs. Upon fertilization, a paternal genome set is introduced, which initiates zygotic Nvtra transcription. This initiates autoregulation of the female specific transcript, leading to female development. This chapter is published as part of: Maternal control of haplodiploid sex determination in the wasp Nasonia. Science (2010) 328 (5978): 620-623.
Using An On-line Digital Tools- Based Program For Fostering EFL Preservice Teachers' Visual Literacy And Self-appraisal

The present study was conducted to investigate the impact of using a program based on online digital tools on fostering EFL pre-service teachers' visual literacy and self-appraisal. The study used the quasi-experimental research method (pre-post control-experimental design). Eighty participants enrolled in the third year, English section at the Faculty of Education were randomly assigned to two intact groups: a treatment group (n=40) and a non- treatment group (n=40). The participants in the treatment group were trained and instructed using a program based on online digital tools whereas their counterparts in the non-treatment group did not receive such training as they received regular instruction. Instruments of the study included a language proficiency test, a needs- analysis survey of 21st teacher competencies, a questionnaire of self-identification, an inventory of visual literacy and a scale of self-appraisal. The findings revealed that the participants in the treatment group significantly surpassed their counterparts in the non-treatment group in the post-performance on the inventory of visual literacy and the scale of self-appraisal.
Modelo para gestionar la capacitación de directivos y reservas en la empresa ganadera cubana. I. Diagnóstico empresarial y del proceso de capacitación

Basado en la situacion existente en la ganaderia cubana y, en general, en la agricultura, e influido por la inexistencia de procedimientos apropiados para gestionar la capacitacion en este sector, se diseno un modelo para gestionar la capacitacion de los directivos y reservas en la empresa ganadera cubana, partiendo de que en dicha organizacion existen insuficiencias en este sentido que hacen inconsistente el cumplimiento de su mision. Asimismo, los diferentes procedimientos especificos que lo integran se derivaron de las necesidades de caracter metodologico de este modelo para gestionar la capacitacion en una secuencia logica; se considera que se debe partir del diagnostico de la empresa con el objetivo de determinar los problemas existentes, seguido por el diagnostico del proceso de capacitacion con el objetivo de conocer como se realiza y las limitaciones que presenta. Se concluye que para la implementacion de este modelo se debe desplegar un conjunto de procedimientos especificos, teniendo como punto de partida el diagnostico empresarial y del propio proceso, los cuales son referentes clave para la identificacion de las necesidades de capacitacion, la planificacion del proceso y de su seguimiento y evaluacion.
Effect of immunocastration in group-housed commercial fattening pigs on reproductive organs, malodorous compounds, carcass and meat quality

In the present study, the effect of immunocastration on carcass traits, meat quality, reproduc - tive organs development, and boar taint compounds was investigated. Male piglets (50% Duroc crosses) were randomly assigned to three treatment groups: entire males (EM; n = 19), surgical castrates (SC; n = 20) and immunocastrates (IC, vaccinated with Improvac ® at the age of 79 and 142 days; n = 21). Pigs were fed ad libitum and weighed at the time of first and second vaccination and before slaughter (176 days of age). No differences between treatment groups were detected for carcass weight. In the case of backfat thickness, carcass lean meat content, and belly leanness score, IC were intermediate between EM (the leanest) and SC (the fattest), differing (P < 0.05) from both control groups. Regarding loin eye fat area, neck intermuscular fatness, ham leanness, and leaf fat weight, IC were similar to EM and were less fat than SC ( P < 0.01). IC had lower intramuscular fat than SC (P < 0.01) and higher average pH 24 than both EM and SC (P < 0.01), resulting in darker colour. IC also demonstrated lower drip loss than EM (P < 0.05). Immunocastration caused a significant reduction of reproductive organs and concentrations of boar taint compounds (P < 0.01) which were comparable with the levels observed for SC.
Factors Influencing Transfer of Training among Employees in Telekom Malaysia

The main aim of the study is to investigate the relationship between factors that influence transfer of training among employees in Telekom Malaysia. Investment of time, efforts and money becomes returns and benefits to organization that provide training to employees. Past study reported that employees fail to transfer knowledge or what they have learned during training. A low motivation can affect the effectiveness of training transfer. Therefore, 148 participants who had undergone training were involved in the study. The questionnaire was used to collect data and 100% returned questionnaires were analyzed using SPSS. The results reveal that 62.5% of the variance in the transfer of training is explained by support, training design and motivation. Further discussion is shared in the article.
Termination of Chromosome Replication

This chapter discusses the components of the terminus-region replication fork-arrest system, their organization and structural features, and their functioning during termination of a round of vegetative replication in Bacillus subtilis. Progress in characterizing and understanding the components and features associated with termination of replication in B. subtilis and Escherichia coli proceeded almost in parallel. The current status of the dif system in B. subtilis is discussed in this chapter. There is emerging evidence to suggest that the replication fork trap might enable more efficient operation of this system. The basis for this will become apparent in the discussion of the various components and features associated with their operation. The functional fork-arrest complex contains two dimers of replication terminator protein (RTP) bound to overlapping A and B sites within the 30-bp terminator. Successful partitioning of replicated daughter chromosomes, generated upon completion of the termination phase of replication, requires the formation of completely separable chromosomes. The existence of multiple sequences of ~8 nt in length with a skewed distribution between the two strands of each oriC-terminus arm (replichore) of the chromosome has more recently been uncovered, and it is now clear that the polarity switch point for these sequences within the terminus region of E. coli coincides with dif. Finally, the chapter focuses on replication fork arrest near oriC under stringent conditions.
Problems of revival and development of animal husbandry in Ukraine

The problem of revival is considered and the current state of development of animal husbandry in Ukraine is investigated. The research is based on the use of state information resources and generalization of scientific developments of domestic and foreign scientists. The changes in the number of farm animals, the volume of livestock production and improving its economic efficiency are analyzed. It is established that the process of revival should be accompanied by the effective use of own financial resources and ensure the sustainable development of all sub-sectors of animal husbandry. To ensure the implementation of effective measures for the revival, stabilization and development of animal husbandry is possible through the effective use of all types of production resources, in particular the genetic potential of animals, the introduction of innovative technologies and economic levers that contribute to the profitability of animal husbandry. The main factors that directly affect the potential of livestock and poultry and increase its productivity are identified. The necessity of creation of the state special fund for revival and support of animal husbandry is specified and the directions of increase of its effective development are offered.
A study of histopathology of H. Pylori gastritis in relation To H. pylori density in gastric biopsies

Introduction: Helicobacter pylori (H. pylori) is of major concern today and is characterized by mucosal infiltration by neutrophils, mononuclear cells and can cause atrophy and intestinal metaplasia which in long term can predispose to gastric carcinoma or lymphoma. Aims of the study: To evaluate the various histopathological parameters in H. pylori induced gastritis and to correlate with H. pylori density. Materials and Methods: This is a Cross sectional descriptive study conducted in the Department of Pathology and Medicine, which included 50 gastric biopsies that was diagnosed as H. Pylori gastritis for a period of 1 year from January 2017 to December 2017. Histopathological variables like Mononuclear cell infiltration, neutrophilic infiltrate, Atrophy, Density of H. pylori were graded according to updated Sydney system. statistical analysis was done using spearman rank correlation test. Results: There were 50 cases of H. pylori gastritis diagnosed during the study period. The age of the patients ranged from 9 to 75 years with male: female ratio of 2.3:1. Atrophy was seen in 25 cases (50%). Mononuclear cell infiltration was seen in all 50 cases (100%). Neutrophilic activity was seen in all 50 cases (100%). Mild activity was seen in 27 (54%) cases. Moderate activity in 10 (20%) cases and severe activity in 13 (26%) cases. H. pylori density was mild in 29 (58%) cases, moderate in 10 (20%) cases and severe in 11 (22%) cases. H. pylori density showed significant correlation with neutrophilic activity. Conclusion: H. pylori density has significant correlation with severity of neutrophilic activity. Chronic inflammation, metaplasia and atrophy did not show significant correlation with H. pylori density.