Miracle-dz/UniFAR-FTUs huggingface dataset:
Product Development of Garcinia cowa Roxb Tea Mixed with High β-Glucan Content from Edible Mushroom

Garcinia cowa Roxb has been used in traditional folk medicine for a long time ago. Moreover, β-glucan from mushrooms also exhibited various medicinal properties. However, no previous researches in product development of G. cowa Roxb leaves mixed with high βglucan content from local edible mushrooms have been found. Therefore, the objective of this research aimed to develop the G. cowa Roxb tea substituted with high -glucan content from local edible mushrooms. From a previous research, the result found that blanched Pleurotus ostreatus was selected based on high -glucan content and its cheap price. Product development of the tea was determined using randomized complete block design (RCBD), which was composed of six treatments– G. cowa Roxb leaves and P. ostreatus powder proportions as follows: 100:0, 80:20, 60:40, 40:60, 20:80, and 0:100, respectively. The result of sensory testing by 50 panelists using 9-point hedonic scale found that the most appropriate ratio of G. Cowa Roxb: P. ostreatus was the 80:20. The highest average liking scores of 4 attributes (colour, aroma, taste, and overall liking were 7.10, 6.16, 6.02, and 6.70, respectively. The physical and chemical characteristic of the product were: 9.22 lightness (L) , 0.56 redness (a), 0.58 yellowness (b), 3.00° Brix total soluble solid , 2.09 pH , and 0.45 aw. Viable plate count, yeast and mold count exhibited less than 10 CFU/g. For the percentage of β-glucan increase, the levels were increased depending on the mushroom content. Interestingly, from the result of consumer testing, most of consumers (35%) rated “extremely like” (7.88 out of 9-point). Ninety-one percent of consumers recognized the new product had more nutritional value added than other marketed tea;76% purchased the new product. In addition, 52% of the consumers accepted the price at 50 baht/package. In summary, this herbal tea could be developed as a healthy food choice in the future.
An Extensive Survey on Image Security Research Trends

The digital revolution of the world along with the fast communication system and the technical advancement of the digital images provide the easiest way to communicate data in the form of Images. There are many open threats and risk involves if these image data is compromised. This paper provides a theoretical study of existing methods for the image security. The archival works from IEEE, Elsevier, Springer and some other relevant articles are considered to do literature study of the problem formulation, algorithms and performance metrics. Various aspects of data integrity, privacy, and attacks are also discussed in this paper. The organized outcome is contributory to the researchers, industry, and academician who keep interest in image security domain.
The Effects of Service Innovation and Service Quality on Customer’s Loyalty in Small Service Enterprise: A Case Study on Car Care Business in Bangkok

This study examines the effects of service innovation and service quality in enhancing the loyalty of customers in small service enterprise by using case study of car care business in Bangkok. By applying American Customer Satisfaction Index (ACSI) model, theoretical framework is developed to examine the causal relationships among service innovation, service quality, perceived value, customer satisfaction and loyalty. Data were collected by questionnaire survey of car care customers in Bangkok and analyzed by using Structural Equation Model (SEM). The findings of this study support and confirm the framework. Accordingly, this implies that car care service providers should improve their service quality through the invention of service innovation in order to enhance customer loyalty, which can help to build up their sustainable competitive advantage to compete in today high competitive and aggressive market.
Phase I and pharmacokinetic study of everolimus, an mTOR inhibitor, in combination with docetaxel for recurrent/refractory non-small cell lung cancer

Purpose—Everolimus is a novel inhibitor of the mammalian target of rapamycin (mTOR) pathway, which is aberrantly activated in non-small cell lung cancer (NSCLC). We conducted a phase I and pharmacokinetic study of everolimus and docetaxel for recurrent NSCLC. Methods—Patients with advanced stage NSCLC and progression following prior platinum-based chemotherapy were eligible. Sequential cohorts were treated with escalating doses of docetaxel (day 1) and everolimus (PO daily, days 1–19), every 3 weeks. Pharmacokinetic (PK) sampling of everolimus and docetaxel were done in cycle 1. The primary endpoint was determination of the recommended phase II doses (RP2D) of the combination. Results—Twenty-four patients were enrolled. Median age, 62 yrs; Females, 11; number of prior regimens, 1(n=13), 2 (n=6), ≥3 (n=5) ECOG PS 0(n=6), 1(n=17). The dose-limiting toxicities (DLT) were fever with grade 3/4 neutropenia, grade 3 fatigue and grade 3 mucositis. None of the 7 patients treated at the RP2D (docetaxel 60 mg/m2 and everolimus 5 mg daily) experienced DLT. Everolimus area under the concentration time curve (AUC) was not different with 60 or 75 mg/m2 docetaxel. Mean ±SD AUC-based accumulation factors (R) for everolimus on days 8 and 15 were 1.16 ± 0.37 and 1.42 ± 0.42, respectively. Docetaxel day 1 half-life was 9.4 ± 3.4 hours. Among 21 patients evaluable, 1 had a partial response, and 10 had disease stabilization. Conclusions—The RP2D of docetaxel and everolimus for combination therapy are 60 mg/m2 and 5 mg PO daily, respectively. Promising anti-cancer activity has been noted.
Potential of Algal Biodiesel Production in Jordan

The need for renewable and eco-friendly fuels arises from the adverse environmental impacts of the conventional fossil fuels. Microalgae cultivation has received considerable interest lately in the academic and industrial fields as a potential source for biofuels production as well as other byproducts such as pharmaceuticals, pigments, and animal feed. Despite their simple structures, microalgae are promising feedstock for the production of biofuels due to their high growth rate and lipid content compared to other energy crops. One of the major setbacks facing the large-scale production of microalgal biofuels is the relatively high production cost due to nutrient and energy input requirements. In this study, the feasibility of microalgae cultivation in Jordan for biodiesel production was investigated. The microalgae cultivation system was assumed to be an open raceway pond with a net area of 1 km and a total algal broth volume of 250,000 m. Different cultivation scenarios were discussed and the materials and energy inputs were based on three literature studies. It was found that relying on the production of biodiesel alone is not economically feasible and will have a negative energy balance. However, by incorporating other processes such as the anaerobic digestion of the algal biomass as well as adapting different cultivation techniques that could reduce the cultivation energy, it is expected that the process will become feasible and will have a positive cash-flow.
The Impact of Health Resort Treatment on the Nonenzymatic Endogenous Antioxidant System

Introduction. Oxygen, reacting with organic compounds in living organisms, oxidizes them without being completely reduced due to numerous exogenous as well as endogenous factors. As a consequence, free radicals or reactive oxygen species are formed. Health resort-based balneophysiotherapy is a comprehensive therapeutic intervention that triggers positive therapeutic effects within the entire system. Material and Methods. The objective of the study was to assess the impact of health resort-based balneophysiotherapy on the levels of nonenzymatic endogenous antioxidants in patients with degenerative motor organ diseases, as well as to determine potential correlation of these changes with free radical-mediated processes. Observation was carried out in patients undergoing health resort therapy as part of 21-day stay periods. The study population consisted of n = 110 patients with articular and spinal pains due to degenerative diseases or discopathies. Results Reduced bilirubin and albumin levels as well as increased uric acid levels were observed in the study group following the health resort treatment. Conclusions Bilirubin and albumin levels were reduced while uric acid levels were increased as the result of health resort therapy in patients with degenerative motor organ diseases. The observed changes in the levels of nonenzymatic endogenous antioxidants depend on free radical-mediated systemic transformations. The trial is registered with NCT03405350.
Paklitaksel’in Oluşturduğu Testis Hasarı Üzerine Resveratrol’ün Koruyucu Etkisinin İncelenmesi

Calismamizda kemoterapik etkiye sahip olan Paklitakselin(PAC) testis organi uzerinde olusturdugu hasarin Resveratrol (RES)’ un koruyucu etkisiyle azaltilmasi amaclanmistir. Calismada Wistar albino turu erkek sicanlar her grupta 10'ar hayvan olacak sekilde kontrol, paklitaksel (PAC) (10mg/kg), resveratrol (RES) (10mg/kg) ve paklitaksel+resveratrol (PAC+RES) (10mg/kg -10 mg/kg) olarak 4 gruba ayrildi. Dokularin genel yapisinin degerlendirilmesi icin Hematoksilen-Eozin ve apoptozisi degerlendirmek icin TUNEL metodu kullanildi. Biyokimyasal olarak testis dokusunda malondialdehyde (MDA), katalaz (CAT) ve superoksit dismutaz (SOD) degerlerine doku orneklerinde bakildi. Sonuc olarak, dokular histopatolojik olarak degerlendirildiginde diger gruplardan farkli olarak PAC grubunda epitelde duzensizlikler ve nekrotik tubullerin sayisinda artis, bag dokusu alanlarinda genisleme gozlendi. TUNEL yontemi sonuclarina gore PAC grubunda TUNEL pozitif hucre sayisi kontrol, RES ve PAC+RES gruplariyla kiyaslandiginda artis gosterdi. Bu sonuclar; testis dokusunda PAC' in olusturdugu oksidatif stresin RES' un meydana getirdigi antioksidan etkiyle azaltilabilecegini gosterdi. Testis dokusundaki MDA, CAT ve SOD degerleri kiyaslandiginda gruplar arasinda anlami bir farklilik bulunmadi( p >0,005). Sonucta PAC bircok organi etkiledigi gibi testis dokusunda da cok ciddi hasarlar olusturmaktadir. Bu hasari engellemek icin PAC kullanimi sirasinda RES’un de kullanilmasi testiste koruyucu ve duzeltici olabilir.
Data selection and semi-supervised slot tagging for artificial intelligent agents

We propose a semi-supervised learning framework to boost the performance of slot tagging in the low resource case, where we only have a small labeled target dataset available for model training, but we have access to a large unlabeled source dataset. Our framework consists of two components: first performing data selection to find a subset of the source data that is semantically similar to the target data, and second, training the model using both selected and target data through a combination of semi-supervised training techniques, inspired from self-training and self ensembling. We apply our techniques to a challenging slot tagging setup for a commercial artificial intelligent agent where unlabeled source data originates from largely different domains compared to the target data. We empirically show that our proposed techniques achieve up to 7% relative gain in low resource slot tagging compared to a strong pretrained model fine-tuned on target training data.
Efficient Secure Two-Party Protocols : Techniques and Constructions by Carmit

4. Understanding and Applying Cryptography and Data Security by Adam J. Elbirt Review by Jérémy Barbay. This book describes cryptographical mechanisms and some of the mathematical concept required to understand them, from a very technical point of view, with a particular emphasis on the techniques of efficient implementation in hardware and software, as well as on the attacks that have been proposed in recent publications.
ORTHOPAEDIC MANIFESTATIONS OF LYME DISEASE

Lyme disease is caused by the spirochete Borrelia burgdorferi and is transmitted by the Ixodes tick. Early diagnosis is difficult because the tick bite may go unnoticed and the distinguishing rash, erythema chronicum migrans, often does not occur. Serologic tests are both sensitive and specific in the later stages of the disease but not in stage 1. Thus diagnosis of Lyme disease remains clinical. Knowledge of the orthopaedic manifestations of Lyme disease may aid in early diagnosis and help differentiate from possible cases of juvenile rheumatoid arthritis and septic arthritis. If septic arthritis is suspected, appropriate antibiotic therapy should be initiated while awaiting serology for Lyme disease. Recurrence of Lyme arthritis following antibiotic treatment is rare. Lyme disease should be considered in any patient with arthritis and a history of rash, fever, or neurologic or cardiac abnormality.
Invoking and Linking Generators from Multiple Hardware Languages using CoreIR

In this paper, we advocate that the EDA community should invest in infrastructure that supports language interoperability and linking, which in turn will promote language diversity, a successful concept in the software world. We begin by observing how the software community has developed standards and infrastructure to support programming language interoperability, followed by discussion of how these techniques can be applied to hardware languages. In particular, this paper proposes applying the concept of software linking to the domain of hardware design. A key issue arises when considering the use of circuit generators, programs that consume parameters and produce hardware circuits. Circuit generators rely on the integration of a programming language and a hardware language, which complicates the notion linking. To address this, we propose the concept of the Foreign Generator Interface (FGI), an adaptation of the of the Foreign Function Interface from software, which enables the construction of hardware designs that use generators from multiple languages. Then, we show how FGI can be used to implement Staged Generator Compilation (SGC), which is a linking-based hardware compilation process inspired by multi-stage programming. Finally, we present CoreIR, a hardware intermediate representation and compiler framework that provides the requisite infrastructure for implementing FGI and SGC.
Carbapenemases Karbapenemazlar

Multidrug-resistant gram-negative bacilli (MDR-GNB) are responsible for more than half of the infections related with healthcare. MDR-GNB infections lead to prolonged hospital stays, increase in hospital expenses and in mortality rates (1). Carbapenemases are vital antibiotic clusters that can show efficiency against chromosome-induced cephalosporinases with many gram-negative agents and against extended spectrum beta-lactamases (ESBL) and are used in the treatment of infections developing with these resistant agents. Prevalent carbapenem use in recent years in the treatment of agent infections producing ESBL and AmpC type beta-lactamases has also resulted in resistance to these antibiotics. The following is a summary of the primary resistance mechanisms that develop against carbapenems: (i) reduced membrane cut-off due to porin loss; (ii) activation of efflux pump enabling antibiotic excretion (iii) occurrence of carbapenemases (carbapenem-destructive enzymes). All of these reasons have given rise to the limitation of the use of these antibiotics and to the emergence of the definition of carbapenem-resistant gram-negative bacilli (CR-GNB) (2,3). Abstract
Perspektif Yaklaşımı ile Çalışma ve Depolama Alanında Hareket Takibi

Calisma sahasindaki is guvenligi, yalnizca kazalar sonrasi tedbirleri almak degil kazaya sebebiyet verecek durumlarin onceden belirlenerek onlemini almaya calismaktir. Goruntu isleme teknikleri, kayitli goruntuler veya anlik goruntuleri tekrar isleyerek istenilenler dogrultusunda yeniden gorsellestirme islemidir. Bu sebeple goruntu isleme teknikleri ile calisma sahasinda kaydedilmis veya canli goruntuler uzerinde iscilerin ve diger nesnelerin takibi yapilarak is guvenligini saglamaya yonelik bir uygulama gerceklestirilebilir. Gerceklestirilmek istenilen amac olusabilecek is kazalarinin onune buyuk olcude gecmeye calismak ayni zamanda kisi ve arac analizi ile birden cok algoritma ve ozelligin kullanimini saglamaktir. Calismada matematiksel algoritmalarin yogunlugu sebebiyle Matlab yazilim programi uygun gorulmustur. Bu yazida yeni cift tarafli ve uyarlamali perspektif yontemlerinin eklenmesiyle bir hareket izleme algoritmasi uygulanmistir. Bu yazinin temel amaci, depolama ve insaat alanlarindaki guvenlik sorunlarinin cozulmesine yardimci olacak bir hareket izleme algoritmasi onermektir. Onerilen algoritma ile santiyede calisan isciler tespit edilir ve santiyede guvenlik gereksinimlerine tamamen uygunlugu kontrol edilir. Detayli algoritma aciklamalari makalenin metodoloji bolumunde bulunabilir. Canli olarak alinan goruntu Matlab ortaminda oncelikle filtreleme ve gurultu temizleme islemleri gibi temel goruntu isleme teknikleri ile hazir hale getirilmis ve sonrasinda goruntude hareket takibi icin nesne bulma ve siniflandirma islemlerine tutulmustur. Nesnenin duzgun bir sekilde bulunmasinin ve takibinin on islmeler ile daha basarili oldugu gorulmektedir. Calisilan ortamin isiklilik durumlari ve hava kosullari ile hareketli veri yogunlugu dogrulugu etkileyen onemli faktorlerdendir. Ilk asama olarak iscilerin belirlenmesi basit siniflandirma teknikleri kullanilarak yapilmistir. Bu siniflandirma kriterleri metodoloji bolumunde aciklanmistir. Siniflandirma islemi dort adimda hareket takibi icin insan veri kumesini saglamistir. Baret takmayan ya da yelek giymeyen ihlale sebep olan saha calisanlari “-” olarak tanimlanip kurallara uyanlar “+” olarak goruntu uzerinde belirtilmistir. Algoritmalarin bu tip goruntuler uzerindeki performansi ve yapilan gelistirmeler sonucu son bolumde degerlendirilmistir
Mitochondrial Dysfunctions May Be One of the Major Causative Factors Underlying Detrimental Effects of Benzalkonium Chloride

Benzalkonium chloride (BAC) is currently the most commonly used antimicrobial preservative in ophthalmic solutions, nasal sprays, and cosmetics. However, a large number of clinical and experimental investigations showed that the topical administration of BAC-containing eye drops could cause a variety of ocular surface changes, from ocular discomfort to potential risk for future glaucoma surgery. BAC-containing albuterol may increase the risk of albuterol-related systemic adverse effects. BAC, commonly present in personal care products, in cosmetic products can induce irritation and dose-dependent changes in the cell morphology. The cationic nature of BAC (it is a quaternary ammonium) suggests that one of the major targets of BAC in the cell may be mitochondria, the only intracellular compartment charged negatively. However, the influence of BAC on mitochondria has not been clearly understood. Here, the effects of BAC on energy parameters of rat liver mitochondria as well as on yeast cells were examined. BAC, being a “weaker” uncoupler, potently inhibited respiration in state 3, diminished the mitochondrial membrane potential, caused opening of the Ca2+/Pi-dependent pore, blocked ATP synthesis, and promoted H2O2 production by mitochondria. BAC triggered oxidative stress and mitochondrial fragmentation in yeast cells. BAC-induced oxidative stress in mitochondria and yeast cells was almost totally prevented by the mitochondria-targeted antioxidant SkQ1; the protective effect of SkQ1 on mitochondrial fragmentation was only partial. Collectively, these data showed that BAC acts adversely on cell bioenergetics (especially on ATP synthesis) and mitochondrial dynamics and that its prooxidant effect can be partially prevented by the mitochondria-targeted antioxidant SkQ1.
Unified Quantile Regression Deep Neural Network with Time-Cognition for Probabilistic Residential Load Forecasting

Residential load forecasting is important for many entities in the electricity market, but the load profile of single residence shows more volatilities and uncertainties. Due to the difficulty in producing reliable point forecasts, probabilistic load forecasting becomes more popular as a result of catching the volatility and uncertainty by intervals, density, or quantiles. In this paper, we propose a unified quantile regression deep neural network with time-cognition for tackling this challenging issue. At first, a convolutional neural network with multiscale convolution is devised for extracting more behavioral features from the historical load sequence. In addition, a novel periodical coding method marks the model to enhance its ability of capturing regular load pattern. Then, features generated from both subnetworks are fused and fed into the forecasting model with an end-to-end manner. Besides, a globally differentiable quantile loss function constrains the whole network for training. At last, forecasts of multiple quantiles are directly generated in one shot. With ablation experiments, the proposed model achieved the best results in the AQS, AACE, and inversion error, and especially the average of the AACE is grown by 34.71%, 75.22%, and 32.44% compared with QGBRT, QCNN, and QLSTM, respectively, indicating that our method has excellent reliability and robustness rather than the state-of-the-art models obviously. Meanwhile, great performances of efficient time response demonstrate that our proposed work has promising prospects in practical applications.
OIL PRODUCTION AND CHANGING CULTURAL PATTERN IN IKWERRE ETHNIC NATION: A CASE OF OBIO-AKPOR

Since oil was discovered in 1956 in commercial quantity in Oloibiri a town 90 kilometers west of Port Harcourt, the capital of Rivers State, life has not been the same with the people of the area. The importance attached on oil production varies from society to society, depending on whether a society is a consumer or producer nation. This study systematically structures the area in order to get a representative sample on how the oil production activity has impacted the area. Theoretically, dialectical materialism is employed since it will enable us to understand how the contradiction observed in the productive pattern of the people and the multinational oil production corporations (MNOPCs) located in the area brings about change in the culture of the people. Records show that oil production is the major economic base of Nigeria and it accounts for over eighty percent of total revenue; over ninety percent of export earnings of the federation and eighty-eight percent of the Gross Domestic Product (GDP). This work shows how oil production activities by the MNOPCs in the area contribute to the perceived changing cultural pattern of the people, for it is true that the production style of a people is a window to the people’s way of life.
Cell Membranes and Free Radical Research

EDITORIAL BOARD Cell Membranes, Ion Channels and Calcium Signaling Alexei Tepikin, The Physiological Laboratory, University of Liverpool, Liverpool, UK Andreas Lückhoff, Institute of Physiology, Medical Faculty, RWTH-Aachen University, Germany Andreas Daiber, 2nd Medical Clinic, Molecular Cardiology, Medical Center of the Johannes Gutenberg University , Mainz, Germany Giorgio Aicardi, Department of Human and General Physiology, University of Bologna, Italy. Gemma A. Figtree, North Shore Heart Research Group Kolling Institute of Medical Research University of Sydney and Royal North Shore Hospital Sydney, AUSTRALIA. Jose Antonio Pariente, Department of Physiology, University of Extremadura, Badajoz, Spain. James W. Putney, Jr. Laboratory of Signal Transduction, NIEHS, NC, USA. Martyn Mahaut Smith, Department of Cell Physiology and Pharmacology, Universtiy of Leicester, Leicester, UK. Stephan M. Huber, Department of Radiation Oncology, Eberhard Karls University Tubingen, Germany