Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis and quantitation of the cross presentation of tumor antigens using the HIV protein transduction domain transactivating regulatory protein (TAT) to alter presentation

ANALYSIS AND QUANTITATION OF THE CROSS PRESENTATION OF TUMOR ANTIGENS USING THE HIV PROTEIN TRANSDUCTION DOMAIN TRANSACTIVATING REGULATORY PROTEIN (TAT) TO ALTER PRESENTATION By Jason Paul Aun The hallmark of cross presentation is the immune system’s ability to present an exogenously derived antigen in the class I major histocompatibility complex (MHC) thus stimulating CD8 TC cells. Exogenously derived proteins are normally presented in a MHC class II with the cells stimulating activation of CD4 TH cells which do not induce the desired cytotoxic effect. Inducing cross presentation is important in cancer immunotherapies because the tumor antigens are presented in the same fashion as exogenous proteins which do not provide the necessary cytotoxic effect. To stimulate a strong cytotoxic immune response, facilitating and optimizing cross presentation is paramount. The purpose of this study was to analyze and quantitate the cross presentation of tumor antigens coupled with the protein transduction domain HIVTAT. Protein transduction domains have the ability to enter a cell independent of any known receptor or endocytic activity. Coupling of a modified version of HER2 with HIV-TAT transferred HER2 to the cytoplasm of the antigen presenting cells. Labeling indicated that there was a slight increase in MHC class I expression using TAT-mHER2 compared to mHER2 alone. We conclude that the results of this study warrant further investigation into optimizing this promising technology.
The Hibernation Quarters of Laspeyresia Molesta Busck1

In 1924, experimental orchard cultivation, supported later by laboratory tests, showed conclusively that thorough cultivation, during the latter part of the month of April, consisting of a plowing to the depth of six inches followed by a disking to the depth of four inches was 100 per cent efficient in the destruction of the larvae and pupae of the Oriental Peach Moth ( Laspeyresia molesta Busck) which had passed the winter upon the ground. The results of further work, in 1925, to determine the relative effectiveness of disking only as compared with plowing only and as compared with these two operations combined, demonstrated the equally high efficiency of a thorough cultivation consisting of disking alone. In 1926 a final study was conducted to determine the relative numbers wintering upon the tree and away from the tree in order to establish the actual extent of the effectiveness of cultivation in the control of this insect. The results of this study indicate the following distribution of the over wintering population under present average conditions in New Jersey—14 per cent in the upper portions of the tree, 11 per cent on the tree trunk and 75 per cent away from the tree—percentages correlated with the adlmdance of mummies and applicable elsewhere subject to variances in infestation and orchard practice. It was also determined that of those larvae overwintering upon the tree trunk 88 per cent constructed hibernacula within the area included in the mound formed when applying paradichlorobenzene for the control of the peach-tree borer, an insecticide also toxic in the case of this insect. These studies, although disclosing the fact that cultivation and the paradichlorobenzene treatment should destroy a high percentage (86%) of the hibernating Oriental Peach Moth, indicate an overwintering population in the upper portions of the tree sufficiently large to constitute a continuance of infestation from year to year in spite of the thorough application of these measures. The knowledge of the relative]y unprotected character and location of these remaining hibernacula suggests the advisability of further work with insecticides of a penetrating nature, with the attendant possibility of placing the control of the insect largely if not wholly within the dormant period.
Effect of Dried Grape Pomace in Diet on the Performance, Carcass and Internal Organ Characteristics in Japanese Quails (Coturnix coturnix japonica)

In this study, the effects of dried grape pomace supplementation to the Japanese quail (Coturnix coturnix japonica) diets on performance, carcass and internal organs characteristics. were investigated. A total of 375, 5-day-old Japanese quails were divided into 5 treatment groups with 5 replications based on live weight of quails. Groups were created according to grape pomace level in the diets: 0 (control) 1, 2, 4 and 6 % dried grape pomace groups. All of the diets were isonitrogenic and isocaloric and all diets were supplemented with 1g/kg Kavimix Safizyme GP 60®. Individual body weights (BW) were measured at 5, 19 and 33 d of age. Also, feed intakes (FI) based on the groups were determined at 19 and 33 d of age. Body weight gain (BWG) and feed conversion ratio (FCR) were calculated from these data. At the end of the experiment the quails were slaughtered and their length of the intestine (duodenum, jejunum and caecum), weights of some internal organs (liver, kidney and gizzard) and carcass weights (hot and cold) and yield were determined. In the study, there were no significant differences among the groups in terms of BW, BWG, FI, FCR and carcass yield (p>0.05). Carcass and internal organ weights and ratios were not affected by the treatments (p> 0.05). It was determined that jejunum length of the quails fed 2% grape pomace, was lower than those of birds in control (0%), 4 and 6% grape pomace groups (p<0.05), and cecal lengths of the quails fed with 4 and 6% grape pomace were significantly lower than those of the birds fed with control and 1% grape pomace containin diets (p<0.001). As a result, it is determined that up to 6% addition of dried grape pomace in quail diets can be used without any negative effect on performance, carcass and internal organ traits of quails.
Flexible intramedullary nails for lengthening of long tubular bones: a comparative study

A comparative study of flexible intramedullary nails (FIN) used for lengthening of long tubular bones in children is presented. It has been found that the presence of calcium phosphate coating obtained by micro-arc oxidation or a composite coating based on a copolymer of vinylidene fluoride with tetrafluoroethylene and hydroxyapatite on the surface of FIN significantly enhances the formation of bone regenerate in the area of osteotomy during limb lengthening by combined osteosynthesis. The investigation of physico-chemical properties of FIN with calcium phosphate coating obtained by micro-arc oxidation demonstrated that improved bone tissue formation is due to favourable conditions for adhesion, proliferation, and differentiation of MMSCs into osteoblasts on the coating surface. Composite coatings stimulated the formation of bone tissue only in vivo, mainly due to the piezoelectric properties of the copolymer of vinylidene fluoride with tetrafluoroethylene.
Monolithic full‐color microdisplay using patterned quantum dot photoresist on dual‐wavelength LED epilayers

A passive‐matrix monolithic full‐color InGaN light emitting diode (LED) microdisplay with 40 × 40 full‐color pixels is demonstrated. Each full‐color pixel consists of red, green, and blue (RGB) subpixels that have a pitch size of 40 μm × 120 μm. The full‐color microdisplay is monolithically fabricated on blue/green dual‐wavelength LED epilayers, using red quantum dot photoresist as a color converter. Pure RGB emission and a wide color gamut are achieved, as shown by electroluminescence spectra. Full‐color patterns with controllable grayscale and color mixing can be clearly rendered driven by a full‐color microdisplay controller, indicating tremendous potential of this novel approach for full‐color LED microdisplays in the future.
Different Socioeconomic Factors Associated with Cervical Cancer

 Abstract — Cervical cancer is the third most common cancer among women. It account for 13% of all female cancers and 85% of these new cases occur in developing countries. This study is a critical review of literature concerning with different risk factors of cervical cancer. In the last section of the study discussion is made for further research point of view.
Selective targeting of tumor cells and protection of mesenchymal stem cells

Stromazellen sind Hauptbestandteil des Microenvironments und stehen im Verdacht, bei pathologischen Entwicklungen mitzuwirken, indem sie das Uberleben, die Zellteilung und die Entwicklung der Tumorzellen unterstutzen. Diese Zellen haben auserdem normale hamostatische, immunmodulierende und das Tumorwachstum supprimierende Fahigkeiten. Stromazellen stammen von mesenchymalen Stammzellen ab und unterliegen einer weiteren Differenzierung zu Osteoblasten, Chondrozyten, Adipozyten und Hamatopoese unterstutzenden Stromazellen. Diese Zellen sind essenziell fur Geweberegeneration, Wundheilung und Hamatopoese. Die Anwendung einer Chemotherapie oder Radiotherapie sowie Zellalterung konnen zum Verlust der normalen physiologischen Funktionen oder gar zur Zerstorung dieser Zellgruppe fuhren. Daraus ergaben sich folgende Ziele, die wir in dieser Arbeit umsetzten: 1.Vorbeugung des Alterungsprozesses in aus dem Knochenmark stammenden mesenchymalen Stammzellen / Stromazellen durch Transfektion mit einer katalytischen Untereinheit des humanen Telomerase kodierendem Gen (hTERT). 2.Untersuchung des Effekts der hTERT Transfection auf die Differenzierungs- fahigkeit der mesenchymalen Stammzellen / Stromazellen zu Osteoblasten und Adipozyten. 3.Untersuchung des Effekts der hTERT Transfection auf die Fahigkeit dieser Zellen, hamatopoetische Zellen zu unterstutzen. Die erhobenen Daten demonstrierten, dass Transfektion mit hTERT eine kurzzeitige (1-2 Wochen dauernde) Induktion der Zellteilung und dadurch einen Anstieg der Gesamtzellzahl bewirkt. Allerdings unterliegen die transfezierten Zellen einer normalen Alterung innerhalb der 4 Wochen Kultivierungszeit, die vergleichbar mit nicht transfezierten Zellen ist. Transfektion mit hTERT hat zudem keinen Effekt auf die Differenzierung der Knochenmark-Stromazellen zu Osteoblasten und Adipozyten sowie auf ihre Fahigkeit, das Uberleben hamatopoetischer Zellen zu unterstutzen. Transfektion mit dominant negativen hTERT zeigte eine masige Hemmung der Osteogenese und eine starke Hemmung der Adipogenese. Wichtige Beobachtung war auserdem, dass hTERT Transfektion keinen Effekt auf den Zellphanotyp der Knochenmark-Stromazellen, sowie keinen Effekt auf die Expression der mit den mesenchymalen Stammzellen assoziierten Faktoren Oct4, Nanog, Lin28 und Sox4 hatte. Zusammenfassend kann festgehalten werden, dass eine hTERT Transfektion der Knochenmark-Stromazellen zu einer Vorbeugung des Alterungsprozesses ohne Phanotypanderung und ohne Beeintrachtigung der normalen Funktionen fuhrt und keine Umwandlung oder Immortalisation dieser Zellen hervorruft. Dies verdeutlicht die potentielle Moglichkeit, eine vorubergehende adenovirale Transfektion der mesenchymalen Stammzellen / Knochenmark-Stromazellen mit hTERT therapeutisch zu nutzen. Diese These bedarf jedoch weitergehender Untersuchungen und experimenteller Bestatigungen.
Study on the age structure and density of the wild apple forest of Malus sieversii

The age structure and crown density of the wild apple forest of Malus sieversii (Ldb.) Roem. , endemic to Gongliu and Xinyuan counties, Xinjiang, were studied. The aim is to provide information for its protection and conservation. Results showed that there were no younglings and only 2 arborets of second class (1%)among the randomly selected 200 trees in the wild apple forest of Gongliu county, appearing a declining trend of it. However, there were 10 arborets of the first class (5%) and 26 arborets of the second class (13%) in Xinyuan wild apple forest, showing a slight ascending feature of it. Crown density of Gongliu wild apple forest was 0.47 and 0.80 of Xinyuan wild apple forest. The survival curves of the two apple forests presented a breakpoint projection profile and an arc projection profile, respectively. So, it is believed that the Gongliu wild apple forest was destructed badly while the Xinyuan wild apple forest was conserved much better.
A Novel Approach of Graph DB for Distributed Computing Environment

-Graph database is a very new paradigm of database that will show new horizons to the world for storing and retrieving structured data. In this paper we propose a system that will work on basic of graph theory and helps to manage the graph database well. This technique will efficiently distributes the graph database and decompose the graph for very efficient parallel query processing. This model has advantage of reducing read wrote latency over the conventional graph database systems.
An atmospheric radiative‐convective model with interactive water vapor transport and cloud development

In the present generation of radiative-convective models, clouds are assigned specific levels or temperatures that do not change during the course of the calculations. In addition, a single water vapor distribution is used for the “mean atmosphere” instead of separate distributions for the clear sky and cloudy sky atmospheres. We present results from a one-dimensional radiative-convective model that includes interactive water vapor transport and predicts cloud altitudes and thicknesses. The fully interactive model and one with a single, fixed cloud with a single water vapor profile can both reproduce a mean global temperature profile, their surface temperatures agreeing within a few tenths of a degree of the observed surface temperature. However, for surface temperature sensitivity studies, major differences between the two models can exist. The differences result from the use of separate clear and cloudy sky water vapor profiles and from the coupling of cloud numbers, locations, and thicknesses to temperature. The interactive model's sensitivities to changes in the maximum altitude of convective extent, carbon dioxide, and surface relative humidity are presented. It is demonstrated that for global average conditions, the assumption of a constant distribution of relative humidity underestimates the water vapor amount and thermal contributions in radiative-convective models. DOI: 10.1111/j.2153-3490.1981. tb01759.x
An examination of the roles played by meaning of feedback and attention to feedback in the "Valins effect."

This study assesses the role played by the variables of meaning and attention in mediating the cognitive effects of false autonomic feedback, first reported by Valins. In the context of a study of the physiological correlates of selective attention, subjects were instructed either to attend or to ignore pulsed sounds that were described either as veridical heart rate feedback or simply as electronic "bleeps. " These auditory stimuli were presented in parallel with slides illustrating skin diseases. Consistent with previous findings, slides associated with acceleration of the pulsed sounds were subsequently rated as significantly more unpleasant than those associated with no change in the speed of these sounds. However, this effect was not contingent on the apparent meaning of these sounds (heart rate vs bleeps) but was contingent on the degree of attention paid to the sounds. The "Valins effect" was only obtained when subjected attended to the sounds. The implications of these findings for the interpretation of the cognitive effects of false autonomic feedback are discussed.
Native Valve Legionella Endocarditis with Devastating Neurological Complications

Legionella is an uncommon cause of infective endocarditis and typically affects prosthetic and homograft valves without associated embolic phenomena. We present a rare case of native valve Legionella endocarditis in a healthy, immunocompetent 42-year-old woman who suffered from devastating neurological complications due to recurrent septic thromboembolism. Over the course of ten months, she had six embolic strokes resulting in significant disabilities as well as recurrent seizures and headaches. Serial Transthoracic (TTE) and Transesophageal Echocardiograms (TEE) as well as an intracardiac echocardiogram were inconclusive and blood cultures remained negative. Nine months after the initial presentation, a repeat TEE revealed a mitral valve vegetation. An elevated Legionella pneumophila IgG titer was found and treatment with levofloxacin led to prompt significant clinical improvement without recurrence of embolic events. Diagnosis of Legionella endocarditis is often delayed due to many factors including negative blood cultures and typically negative TEEs. This case report emphasizes the importance of maintaining a high clinical index of suspicion for atypical causes of culture-negative endocarditis for accurate diagnosis and successful treatment. In addition, it illuminates the importance of repeating diagnostic studies over time in complicated undiagnosed cases.
Survival and movements of orphaned white-tailed deer fawns in Texas

Harvest of females can be a controversial but necessary tool in managing white-tailed deer (Odocoileus virginianus) populations. Because little is known about the effects of female harvest on their orphaned fawns, we compared survival rates, home range area, and movement rates between fawns (7 M, 7 F) orphaned during early November, and unorphaned (4 M, 6 F) fawns for 11 months postorphaning. Distance moved during 3-6-hr periods (P = 0.498) and 21-27-br periods (P = 0.502) did not differ between orphaned and unorphaned fawns. However, compared with unorphaned fawns, orphaned fawns had smaller home ranges (95% minimum convex polygon [MCP]: 153 vs. 285 ha, P = 0.015, n = 23; 95% harmonic mean [HM]: 191 vs. 314 ha, P = 0.035, n = 23), and lower survival rates (0.79 vs. 1.00; P = 0.060, n = 24). Our results suggest early-season female deer harvest may negatively affect fawns, potentially reducing recruitment. Therefore, managers should carefully consider the timing of female harvests relative to management goals and harvest strategies.
Seroprevalance of Chlamydophila abortus Infections in Goats in Burdur Province Burdur İlinde Keçilerde Chlamdophila abortus Enfeksiyonunun Seroprevalansı

Chlamydophila abortus is the causative agent of enzootic abortion (OEA) in sheep that causes severe economic loss in sheep and goat breeding worldwide. The aim of this study was to detect the seroprevalence of C. abortus infection in goat flocks in Burdur province of Turkey. A total of 384 blood serum samples were collected from two years and older goat in randomly selected 22 goat flocks. The apparent and true seroprevalences of individual, withinflock and betweenflocks of the C. abortus infection were determined in goats by a commercial the enzyme linked immunosorbent assay (ELISA) kit. The apparent and true seroprevalence of C. abortus individual, withinflock and between-flocks was calculated as 19.27%, 22.77%, 86.36% and 19.44%, 23.16% and 90.81%, respectively. The seropositivity of C. abortus infection to according to flock size were statistically significant (p˂0.05) between some goat flocks. There was no statistically significant difference between goat breed and C. abortus infection (p˃0.05). In conclusion, these findings showed that C. abortus infection is found high rates in goat flocks in Burdur and the control and eradication programs should be started to prevent the spreading of C. abortus.
DStress: Automatic Synthesis of DRAM Reliability Stress Viruses using Genetic Algorithms

Failures become inevitable in DRAM devices, which is a major obstacle for scaling down the density of cells in future DRAM technologies. These failures can be detected by specific DRAM tests that implement the data and memory access patterns having a strong impact on DRAM reliability. However, the design of such tests is very challenging, especially for testing DRAM devices in operation, due to an extremely large number of possible cell-to-cell interference effects and combinations of patterns inducing these effects.In this paper, we present a new framework for the synthesis of DRAM reliability stress viruses, DStress. This framework automatically searches for the data and memory access patterns that induce the worst-case DRAM error behavior regardless the internal DRAM design. The search engine of our framework is based on Genetic Algorithms (GA) and a programming tool that we use to specify the patterns examined by GA. To evaluate the effect of program viruses on DRAM reliability, we integrate DStress with an experimental server where 72 DRAM chips can operate under various operating parameters and temperatures.We present the results of our 7-month experimental study on the search of DRAM reliability stress viruses. We show that DStress finds the worst-case data pattern virus and the worst-case memory access virus with probabilities of 1 − 4 × 10−7 and 0.95, respectively. We demonstrate that the discovered patterns induce by at least 45% more errors than the traditional data pattern micro-benchmarks used in previous studies. We show that DStress enables us to detect the marginal DRAM operating parameters reducing the DRAM power by 17.7 % on average without compromising reliability. Overall, our framework facilitates the exploration of new data patterns and memory access scenarios increasing the probability of DRAM errors, which is essential for improving the state-of-the-art DRAM testing mechanisms.
Building the Computing System for Autonomous Micromobility Vehicles: Design Constraints and Architectural Optimizations

This paper presents the computing system design in our commercial autonomous vehicles, and provides a detailed performance, energy, and cost analyses. Drawing from our commercial deployment experience, this paper has two objectives. First, we highlight design constraints unique to autonomous vehicles that might change the way we approach existing architecture problems. Second, we identify new architecture and systems problems that are perhaps less studied before but are critical to autonomous vehicles.
Influence of order in stepwise electroless depositi n on anode properties of thick-film electrodes consistin g of Si particles coated with Ni and Cu

Nickel and copper were coated on Si particles by a stepwise electroless deposition technique in which the coating orders of the metals were exchang ed. Thick-film electrodes for Li-ion batteries were prepared by a gas-deposition method using the coated Si particles, and the anode performance of these electrodes was investigated. For (Cu, Ni)coated Si particles obtained by primary Cu deposition and successive Ni deposition, Cu and Ni metal layers were individually deposited on the Si particles. In contrast, in case of (Ni, Cu)-coat ed Si particles prepared by primary Ni deposition, Cu layer stacked on Ni layer owing to a high catalytic activity of Ni, forming a thicker coated layer. Th e latter electrode exhibited notably improved perform ance with the discharge capacities over 1000 mA h g maintained until 400th cycle. The layer stack of C u on Ni is probably effective for a release of a stress from the Si particles during charge–discharg e reactions. brought to you by CORE View metadata, citation and similar papers at core.ac. uk provided by Tottori University Research Result Repository
Non-universality of reflexive analysis for anticausativization Evidence from the Hokkaido dialect of Japanese

Anticausativization is a morphological process where a certain morphological marking incurs the suppression of the causing event and of the external argument. Koontz-Garboden (2009)advocated an analysis where the semantic operation responsible for anticausativization is reflexivization,i.e.,co-indexing of external and internal arguments. He argues that this analysis is applicable to anticausativization“in general,”i.e.,not only to anticausativization with reflexive morphemes but also to anticausativizaiton employing other types of morpheme as a marker of anticausativization. This paper examines the viability of this universal characterization,using the data from the Hokkaido dialect of Japanese.