Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of human growth hormone in a cachectic post-traumatic crush injury patient

Somatropin, recombinant human growth hormone, is used for the treatment of growth hormone deficiencies and conditions with associated weight loss. A 42-year-old male was admitted to the trauma service after suffering a traumatic crush injury. Approximately five months later, the patient was readmitted due to cachexia and intractable vomiting. Somatropin (0.1 mg/kg) injection therapy was initiated. This was a novel therapeutic approach to a patient that was otherwise declining. Despite complications with nutrition, somatropin appeared to augment weight gain.
Point-of-Use Nanobiosensor for Detection of Dengue Virus NS1 Antigen in Adult Aedes aegypti: A Potential Tool for Improved Dengue Surveillance.

Dengue virus (DENV) and its primary mosquito vectors Aedes spp. have spread to every continent except Antarctica, causing outbreaks and autochthonous transmission in previously disease-free regions. Recently, the spread of other arboviruses carried by invasive Aedes spp. , such as Chikungunya and Zika, seem to be following similar trends as DENV and have renewed interest in monitoring and modeling arboviruses within mosquito vectors. Unfortunately, current commercially available detection methods are designed for the diagnosis of DENV in humans or are too expensive and complex for sustainable monitoring. We report a novel electronic nanobiosensor utilizing a single-walled carbon nanotube networks chemiresistor transducer functionalized with antidengue NS1 monoclonal antibodies for rapid detection of the dengue nonstructural protein 1 (NS1). NS1 is a highly conserved protein secreted at high concentrations during viral replication and is a biomarker for DENV infection. NS1 was successfully detected in spiked adult Aedes aegypti homogenate over a broad dynamic range with high sensitivity and selectivity. The biosensor is compatible with "gold-standard" adult mosquito field-collection protocols and generates electronic data that can be readily stored or wirelessly transmitted. Thus, it has potential for remote and real-time monitoring of wild mosquito populations.
Application QoS management for the reverse link of a 3G network

Third generation (3G) wireless networks have been designed to provide high speed data services on both forward and reverse links. In addition to increased data capacity, they also support QoS (quality of service) for mobile users. Users may run multiple applications (service instances) simultaneously and QoS guarantees must be assured for one or more of them. We address the problem of providing QoS guarantees on the reverse link of a 3G (CDMA) network. We present a flexible, low overhead framework for efficient management of the reverse link resources to satisfy the QoS guarantees of each user's applications. We show how the QoS demands of all service instances of a particular user can be converted and combined into a single resource demand, namely the data rate of the corresponding reverse link channel.
Expanding Oxygen-Minimum Zones in the Tropical Oceans

Oxygen-poor waters occupy large volumes of the intermediate-depth eastern tropical oceans. Oxygen-poor conditions have far-reaching impacts on ecosystems because important mobile macroorganisms avoid or cannot survive in hypoxic zones. Climate models predict declines in oceanic dissolved oxygen produced by global warming. We constructed 50-year time series of dissolved-oxygen concentration for select tropical oceanic regions by augmenting a historical database with recent measurements. These time series reveal vertical expansion of the intermediate-depth low-oxygen zones in the eastern tropical Atlantic and the equatorial Pacific during the past 50 years. The oxygen decrease in the 300- to 700-m layer is 0.09 to 0.34 micromoles per kilogram per year. Reduced oxygen levels may have dramatic consequences for ecosystems and coastal economies.
Soap tackles stigma of schizophrenia

Dr Adrianne Reveley has been a professional adviser to the National Schizophrenia Fellowship for many years. When the BBC soap opera Eastenders decided that a character would have schizophrenia, the charity asked Dr Reveley to help Advising Eastenders on their schizophrenia story should be highlighted in red ink on my curriculum vitae. Everyone has been impressed. Our cleaner, Evelyn, long since promoted from cleaning my office to cleaning the neurosurgical unit, stopped me to ask if it were true. How did she know? The porters now greet me with a respect previously offered only to the chief executive. My teenage son, Tom, was disbelieving; I must really know my stuff if Eastenders used me as a source. Of course, the downside is that every jarring nuance of the story and every inaccuracy is laid at my door, and there …
Horizontally Transferred Genetic Elements and Their Role in Pathogenesis of Bacterial Disease

This article reviews the roles that laterally transferred genes (LTG) play in the virulence of bacterial pathogens. The features of LTG that allow them to be recognized in bacterial genomes are described, and the mechanisms by which LTG are transferred between and within bacteria are reviewed. Genes on plasmids, integrative and conjugative elements, prophages, and pathogenicity islands are highlighted. Virulence genes that are frequently laterally transferred include genes for bacterial adherence to host cells, type 3 secretion systems, toxins, iron acquisition, and antimicrobial resistance. The specific roles of LTG in pathogenesis are illustrated by specific reference to Escherichia coli, Salmonella, pyogenic streptococci, and Clostridium perfringens.
Effective Hemostasis in Cardiac Surgery

Inevitably, reading is one of the requirements to be undergone. To improve the performance and quality, someone needs to have something new every day. It will suggest you to have more inspirations, then. However, the needs of inspirations will make you searching for some sources. Even from the other people experience, internet, and many books. Books and internet are the recommended media to help you improving your quality and performance.
Selective Blockade of MicroRNA Processing by Lin28

MicroRNAs (miRNAs) play critical roles in development, and dysregulation of miRNA expression has been observed in human malignancies. Recent evidence suggests that the processing of several primary miRNA transcripts (pri-miRNAs) is blocked posttranscriptionally in embryonic stem cells, embryonal carcinoma cells, and primary tumors. Here we show that Lin28, a developmentally regulated RNA binding protein, selectively blocks the processing of pri-let-7 miRNAs in embryonic cells. Using in vitro and in vivo studies, we found that Lin28 is necessary and sufficient for blocking Microprocessor-mediated cleavage of pri-let-7 miRNAs. Our results identify Lin28 as a negative regulator of miRNA biogenesis and suggest that Lin28 may play a central role in blocking miRNA-mediated differentiation in stem cells and in certain cancers.
Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

It is well established that high doses of monomeric immunoglobulin G (IgG) purified from pooled human plasma [intravenous immunoglobulin (IVIG)] confer anti-inflammatory activity in a variety of autoimmune settings. However, exactly how those effects are mediated is not clear because of the heterogeneity of IVIG. Recent studies have demonstrated that the anti-inflammatory activity of IgG is completely dependent on sialylation of the N-linked glycan of the IgG Fc fragment. Here we determine the precise glycan requirements for this anti-inflammatory activity, allowing us to engineer an appropriate IgG1 Fc fragment, and thus generate a fully recombinant, sialylated IgG1 Fc with greatly enhanced potency. This therapeutic molecule precisely defines the biologically active component of IVIG and helps guide development of an IVIG replacement with improved activity and availability.
Association between activity level and changes in bodyweight in dementia patients

Introduction: Bodyweight is routinely used as an important health assessment measure in care facilities. Recently, the integrated circuit (IC) tag monitoring system became available for measuring the distance walked by patients with dementia (PsWD) over an extended period. The main objective of the present study was to examine an association between the distance walked and changes in bodyweight in PsWD.
Low-Magnetic-Field Control of Electric Polarization Vector in a Helimagnet

The mutual control of the electric and magnetic properties of a solid is currently of great interest because of the possible application for novel electronic devices. We report on the low-magnetic-field (for example, B values of ±30 milliteslas) control of the polarization (P) vector in a hexaferrite, Ba2Mg2Fe12O22, which shows the helimagnetic spin structure with the propagation vector k0 parallel to [001]. The B-induced transverse conical spin structure carries the P vector directing perpendicular to both B and k0, in accord with the recently proposed spin-current model. Then, the oscillating or multidirectionally rotating B produces the cyclic displacement current via the flexible handling of the magnetic cone axis.
Mass Spectrometry Analysis in Atmospheric Chemistry.

In the Earth’s atmosphere, numerous gas-phase species and airborne particles form a complex mixture called atmospheric aerosol. A variety of natural and anthropogenic primary emission sources along with chemical and photochemical transformations of the emitted compounds in the atmosphere contribute to a large diversity of aerosols, which often contain hundreds of individual components existing in different phases in a dynamic gas-particle exchange.1-3 Common examples of atmospheric aerosols include sea-salt spray (SSA), biomass burning organic aerosol (BBOA), mineral dust, soot, biological aerosol, and forest haze. Organic aerosol (OA) is commonly categorized either as a primary organic aerosol (POA) or secondary organic aerosol (SOA) depending on how it is produced. However, this distinction is quickly erased by the chemical and physical aging processes in the atmosphere. In the aerosol system, concentrations of individual compounds both in the gas- and condensed phases can differ by orders of magnitude.
Determination of the Permittivity of Building Materials through WLAN Measurements at 2.4 GHz

In this paper a new approach for the calibration of electromagnetic material parameters (permittivity) of 3D ray tracing prediction model at 2.4 GHz is presented. The calibration procedure is based on measurements of the channel impulse response using cross-correlation techniques and the 802.11b preamble. Further developments of a method, which has been published earlier, are presented. The analysis of the permittivity of different walls determined from a short measurement campaign is shown
Laguna Negra Virus Infection Causes Hantavirus Pulmonary Syndrome in Turkish Hamsters (Mesocricetus brandti)

Laguna Negra virus (LNV) is a New World hantavirus associated with severe and often fatal cardiopulmonary disease in humans, known as hantavirus pulmonary syndrome (HPS). Five hamster species were evaluated for clinical and serologic responses following inoculation with 4 hantaviruses. Of the 5 hamster species, only Turkish hamsters infected with LNV demonstrated signs consistent with HPS and a fatality rate of 43%. Clinical manifestations in infected animals that succumbed to disease included severe and rapid onset of dyspnea, weight loss, leukopenia, and reduced thrombocyte numbers as compared to uninfected controls. Histopathologic examination revealed lung lesions that resemble the hallmarks of HPS in humans, including interstitial pneumonia and pulmonary edema, as well as generalized infection of endothelial cells and macrophages in major organ tissues. Histologic lesions corresponded to the presence of viral antigen in affected tissues. To date, there have been no small animal models available to study LNV infection and pathogenesis. The Turkish hamster model of LNV infection may be important in the study of LNV-induced HPS pathogenesis and development of disease treatment and prevention strategies.
Caracterización molecular de aislamientos invasores colombianos de Streptococcus pneumoniae serotipo 5 recuperados entre 1994 y 2004.

Introduccion. Streptococcus pneumoniae serotipo 5 es causa importante de enfermedad invasora en Colombia, donde se ha demostrado la circulacion del clon 19-Colombia(5) susceptible a penicilina pero resistente a tetraciclina y a cloranfenicol. Objetivo. Establecer las relaciones geneticas de aislamientos invasores colombianos de S. pneumoniae serotipo 5 recuperados entre 1994 y 2004 con el clon 19-Colombia(5). Materiales y metodos. Se estudiaron 83 aislamientos que tenian datos de susceptibilidad a penicilina, vancomicina, ceftriaxona, eritromicina, trimetoprim sulfametoxazol, cloranfenicol y tetraciclina, de los cuales 29 fueron obtenidos de ninos menores de cinco anos. El patron de restriccion del ADN se determino por electroforesis en gel de campo pulsado, usando la enzima Sma I. La similitud genetica entre los aislamientos y el clon se establecio segun los criterios de Tenover y utilizando el programa Fingerprinting II. Resultados. Todos los aislamientos se relacionaron con el clon 19-Colombia5 y se agruparon en el patron electroforetico A con 17 subtipos. El patron A se establecio en 32 aislamientos (38,6%), el A8 en 18 (21,7%) y el A5 en 10 (12%), los 15 patrones restantes agruparon los otros 23 aislamientos. Los 34 aislamientos resistentes a tetraciclina y cloranfenicol mostraron relacion con los patrones electroforeticos A (n = 32), A16 (n = 1) y A28 (n = 1), caracterizados, al igual que el clon, por presentar una banda de 340 Kb. Conclusion. Estos resultados muestran la circulacion continua en el pais de aislamientos de S. pneumoniae serotipo 5 geneticamente relacionados con el clon 19-Colombia(5).
Gross and Microscopic Lesions in Corals from Micronesia

The authors documented gross and microscopic morphology of lesions in corals on 7 islands spanning western, southern, and eastern Micronesia, sampling 76 colonies comprising 30 species of corals among 18 genera, with Acropora, Porites, and Montipora dominating. Tissue loss comprised the majority of gross lesions sampled (41%), followed by discoloration (30%) and growth anomaly (29%). Of 31 cases of tissue loss, most lesions were subacute (48%), followed by acute and chronic (26% each). Of 23 samples with discoloration, most were dark discoloration (40%), with bleaching and other discoloration each constituting 30%. Of 22 growth anomalies, umbonate growth anomalies composed half, with exophytic, nodular, and rugose growth anomalies composing the remainder. On histopathology, for 9 cases of dark discoloration, fungal infections predominated (77%); for 7 bleached corals, depletion of zooxanthellae from the gastrodermis made up a majority of microscopic diagnoses (57%); and for growth anomalies other than umbonate, hyperplasia of the basal body wall was the most common microscopic finding (63%). For the remainder of the gross lesions, no single microscopic finding constituted >50% of the total. Host response varied with the agent present on histology. Fragmentation of tissues was most often associated with algae (60%), whereas necrosis dominated (53%) for fungi. Two newly documented potentially symbiotic tissue-associated metazoans were seen in Porites and Montipora. Findings of multiple potential etiologies for a given gross lesion highlight the importance of incorporating histopathology in coral disease surveys. This study also expands the range of corals infected with cell-associated microbial aggregates.
Design And Implementation Of 02244 TDS Meter Gravity Sensor And 4502C pH Sensor On Hydroponic

Hydroponics is a method of sprouting plants in a nutrient solution without the use of sawdust, coir dust, coconut fiber etc. The technique has been followed in countries such as the United States. Hydroponic plants maintain adequate nutrition, ambient temperature and pH (hydrogen potential). The author uses 2 sensors, namely a gravity sensor tds meter and a pH sensor. On the pH and nutrient parameters to meet the accuracy of the stability of the water value, the controller will order to check the water value at intervals of 3 hours periodically. At an interval of 3 hours and the nutritional state is lacking, the water pump will pump nutrient water a and $\mathbf{b}$ for 1 second and if the 3 hour interval the nutrients have not been fulfilled then the next 3 hour interval the pump will move one second. This mechanism will continue to repeat until the nutritional value is met as well as the pH sensor using an interval of 3 hours and using the same concept as the water nutrition mechanism.
Localization of Bovine Papillomavirus Nucleic Acid in Equine Sarcoids

Bovine papillomaviruses (BPV1/BPV2) have long been associated with equine sarcoids; deciphering their contribution has been difficult due to their ubiquitous presence on skin and in the environment, as well as the lack of decent techniques to interrogate their role in pathogenesis. We have developed and characterized an in situ hybridization (ISH) assay that uses a pool of probes complementary to portions of the E5, E6, and E7 genes. This assay is highly sensitive for direct visualization of viral transcript and nucleic acid in routinely processed histopathologic samples. We demonstrate here the visualization of BPV nucleic acid in 18 of 18 equine sarcoids, whereas no detectable viral DNA was present in 15 of 15 nonsarcoid controls by this technique. In nearly 90% (16/18) of the sarcoids, 50% or more of the fibroblastic cell nuclei distributed throughout the neoplasm had detectable hybridization. In the remaining 2 cases, fewer than half of the fibroblastic cells contained detectable hybridization, but viral nucleic acid was also detected in epithelial cells of the sebaceous glands, hair follicles and epidermis. A sensitive ISH assay is an indispensable addition to the molecular methods used to detect viral nucleic acid in tissue. We have used this technique to determine the specific cellular localization and distribution of BPV in a subset of equine sarcoids.
The Eukaryotic Genome as an RNA Machine

The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number of non–protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident that many of these RNAs have regulatory functions. Here, we highlight recent advances that illustrate the diversity of ncRNA control of genome dynamics, cell biology, and developmental programming.
Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long‐Term Engraftment and No Ectopic Tissue Formation

Mesenchymal stromal cells (MSCs) are explored as a novel treatment for a variety of medical conditions. Their fate after infusion is unclear, and long‐term safety regarding malignant transformation and ectopic tissue formation has not been addressed in patients. We examined autopsy material from 18 patients who had received human leukocyte antigen (HLA)‐mismatched MSCs, and 108 tissue samples from 15 patients were examined by PCR. No signs of ectopic tissue formation or malignant tumors of MSC‐donor origin were found on macroscopic or histological examination. MSC donor DNA was detected in one or several tissues including lungs, lymph nodes, and intestine in eight patients at levels from 1/100 to <1/1,000. Detection of MSC donor DNA was negatively correlated with time from infusion to sample collection, as DNA was detected from nine of 13 MSC infusions given within 50 days before sampling but from only two of eight infusions given earlier. There was no correlation between MSC engraftment and treatment response. We conclude that MSCs appear to mediate their function through a “hit and run” mechanism. The lack of sustained engraftment limits the long‐term risks of MSC therapy. STEM CELLS2012;30:1575–1578
Closed-loop precoding based on code distance allocation for transmit correlated spatial multiplexing MIMO systems

When MIMO channel correlation information is available at the transmitter, closed-loop precoding can be introduced to improve system performance. In this paper, we proposed a novel closed-loop precoding algorithm based on code distance allocation for transmit correlated spatial multiplexing MIMO systems. We show that pairwise error probability of transmit correlated spatial multiplexing MIMO systems is determined by the minimum transmit code distance allocated to each eigenmode subchannel. We give the structure of code distance allocation matrix to optimize transmit code distance. Our proposed structure of code distance allocation matrix can simultaneously optimize minimum code distance allocated to each subchannel. Computer simulations show that our proposed procoding algorithm can improve the performance of transmit correlated spatial multiplexing systems
Chronic Kidney Disease in Aged Cats

Chronic kidney disease (CKD) is the most common metabolic disease of domesticated cats, with most affected cats being geriatric (>12 years of age). The prevalence of CKD in cats exceeds that observed in dogs, and the frequency of the diagnosis of CKD in cats has increased in recent decades. Typical histologic features include interstitial inflammation, tubular atrophy, and fibrosis with secondary glomerulosclerosis. In contrast to people and dogs, primary glomerulopathies with marked proteinuria are remarkably rare findings in cats. Although a variety of primary renal diseases have been implicated, the disease is idiopathic in most cats. Tubulointerstitial changes, including fibrosis, are present in the early stages of feline CKD and become more severe in advanced disease. A variety of factors—including aging, ischemia, comorbid conditions, phosphorus overload, and routine vaccinations—have been implicated as factors that could contribute to the initiation of this disease in affected cats. Factors that are related to progression of established CKD, which occurs in some but not all cats, include dietary phosphorus intake, magnitude of proteinuria, and anemia. Renal fibrosis, a common histologic feature of aged feline kidneys, interferes with the normal relationship between peritubular capillaries and renal tubules. Experimentally, renal ischemia results in morphologic changes similar to those observed in spontaneous CKD. Renal hypoxia, perhaps episodic, may play a role in the initiation and progression of this disease.
Anticorrelated Seismic Velocity Anomalies from Post-Perovskite in the Lowermost Mantle

Earth's lowermost mantle has thermal, chemical, and mineralogical complexities that require precise seismological characterization. Stacking, migration, and modeling of over 10,000 P and S waves that traverse the deep mantle under the Cocos plate resolve structures above the core-mantle boundary. A small –0.07 ± 0.15% decrease of P wave velocity (Vp) is accompanied by a 1.5 ± 0.5% increase in S wave velocity (Vs) near a depth of 2570 km. Bulk-sound velocity \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \([V_{\mathrm{b}}=(V_{\mathrm{p}}^{2}-\frac{4}{3}V_{\mathrm{s}}^{2})^{\frac{1}{2}}]\) \end{document} decreases by –1.0 ± 0.5% at this depth. Transition of the primary lower-mantle mineral, (Mg1-x-y FexAly)(Si,Al)O3 perovskite, to denser post-perovskite is expected to have a negligible effect on the bulk modulus while increasing the shear modulus by ∼6%, resulting in local anticorrelation of Vb and Vs anomalies; this behavior explains the data well.