Miracle-dz/UniFAR-FTUs huggingface dataset:
INFLUÊNCIA DA FLEXIBILIDADE NO DESEMPENHO EM SALTOS VERTICAIS

Alguns estudos apontam que individuos com unidades musculo-tendineas com menor amplitude de movimento sao capazes de utilizar melhor a energia elastica armazenada na estrutura do tendao em movimentos que envolvem as acoes excentrica e concentrica. Assim, o objetivo desse estudo foi verificar a influencia da flexibilidade de membros inferiores na diferenca de desempenho entre o salto Squat Jump (SJ) e o salto Countermovement Jump (CMJ). Doze voluntarios do genero masculino foram submetidos a goniometria de membros inferiores, para avaliacao da flexibilidade, na qual foram mensuradas a amplitude de movimento em flexao e extensao de quadril e em dorsiflexao. Posteriormente, foram realizados os testes de saltos verticais e determinada a diferenca de desempenho entre os resultados do SJ e os resultados do CMJ. Foi encontrada uma alta correlacao inversa (r= -0,81, p<0,05) entre a amplitude de movimento na flexao de quadril e a melhora do desempenho do SJ para o CMJ. Para a extensao de quadril e dorsiflexao foi encontrada baixa correlacao inversa (r = -0,45 e r = -0,26 respectivamente, p<0,05). Diante destes resultados foi possivel concluir que ha um maior aumento do desempenho entre os saltos SJ e CMJ em individuos com menor ADM na flexao de quadril. Estes resultados sugerem que individuos com menor flexibilidade nos musculos extensores do quadril possuem um maior aproveitamento da energia elastica armazenada durante a acao excentrica no CMJ.
Tétano en un equino Criollo Colombiano

El tetano es una enfermedad causada por neurotoxinas producidas por el bacilo gram positivo Clostridium tetani . Los signos se caracterizan por la presencia de espasmos musculares, rigidez generalizada, disfagia, ataxia y decubito permanente con la posterior muerte del animal. El tratamiento principal consiste en la eliminacion de la bacteria (antibioticos) y de la toxina, neutralizacion de la misma antes de su union con el neurotransmisor (suero antitetanico), y el establecimiento de inmunidad (vacunacion); ademas del tratamiento medico de apoyo con analgesicos, sedantes, relajantes musculares y suplementos vitaminicos. El pronostico depende de varios factores como el estado inmune del animal, la dosis de bacteria inoculada, la duracion y disponibilidad del tratamiento, y los cuidados de soporte. El objetivo de este trabajo es presentar el tratamiento y evolucion de un caso de tetano en una potranca raza Criollo Colombiano de seis meses de edad, la cual fue atendida en la Clinica Veterinaria Lasallista.
Maxillary sinus grafting with Bio-Oss or Straumann Bone Ceramic: histomorphometric results from a randomized controlled multicenter clinical trial.

INTRODUCTION This investigation was designed to compare the histomorphometric results from sinus floor augmentation with anorganic bovine bone (ABB) and a new biphasic calcium phosphate, Straumann Bone Ceramic (BCP). MATERIALS AND METHODS Forty-eight maxillary sinuses were treated in 37 patients. Residual bone width was > or =6 mm and height was > or =3 mm and <8 mm. Lateral sinus augmentation was used, with grafting using either ABB (control group; 23 sinuses) or BCP (test group; 25 sinuses); sites were randomly assigned to the control or test groups. After 180-240 days of healing, implant sites were created and biopsies taken for histological and histomorphometric analyses. The parameters assessed were (1) area fraction of new bone, soft tissue, and graft substitute material in the grafted region; (2) area fraction of bone and soft tissue components in the residual alveolar ridge compartment; and (3) the percentage of surface contact between the graft substitute material and new bone. RESULTS Measurable biopsies were available from 56% of the test and 81.8% of the control sites. Histology showed close contact between new bone and graft particles for both groups, with no significant differences in the amount of mineralized bone (21.6+/-10.0% for BCP vs. 19.8+/-7.9% for ABB; P=0.53) in the biopsy treatment compartment of test and control site. The bone-to-graft contact was found to be significantly greater for ABB (48.2+/-12.9% vs. 34.0+/-14.0% for BCP). Significantly less remaining percentage of graft substitute material was found in the BCP group (26.6+/-5.2% vs. 37.7+/-8.5% for ABB; P=0.001), with more soft tissue components (46.4+/-7.7% vs. 40.4+/-7.3% for ABB; P=0.07). However, the amount of soft tissue components for both groups was found not to be greater than in the residual alveolar ridge. DISCUSSION Both ABB and BCP produced similar amounts of newly formed bone, with similar histologic appearance, indicating that both materials are suitable for sinus augmentation for the placement of dental implants. The potential clinical relevance of more soft tissue components and different resorption characteristics of BCP requires further investigation.
Magnetic induction channel models and link budgets: A comparison between two Agbinya-Masihpour models

Near Field Magnetic Induction Communication (NFMIC) is emerging as an appreciatively beneficial physical layer access method in short range communication. Although it provides more secure, robust and power efficient system than traditional Electro-Magnetic (EM) RF-based systems, its capabilities and characteristics have not been widely studied. Therefore, in this paper, we have explored this technology from the link budget perspective, since this concept is one of the most fundamental requirements of any communication system. An efficient link budget is critical to the NFMIC systems where the power decreases with distance with higher rate than RF-based systems. We have thus examined the impacts of two channel models of Agbinya-Masihpour (AM) and Agbinya-Masihpour1 (AM1), which we have developed. We present these two models based on a common formalism. Then we have compared the performance of the two models in three different frequency bands 13.56MHz, 300MHz and 900MHz. According to the theoretical analysis as well as simulation results we have shown that the Agbinya-Masihpour model performs much higher than the Agbinya-Masihpour 1 model specifically in higher frequencies. The results suggest that longer distances are achievable through the Agbinya-Masihpour channel model.
Use Cases and Operational Experience with Multipath TCP

This document discusses both use cases and operational experience with Multipath TCP (MPTCP) in real networks. It lists several prominent use cases where Multipath TCP has been considered and is being used. It also gives insight to some heuristics and decisions that have helped to realize these use cases and suggests possible improvements.
cAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdala

NMDA receptor-dependent long-term potentiation (LTP) of glutamatergic synaptic transmission in sensory pathways from auditory thalamus or cortex to the lateral amygdala (LA) underlies the acquisition of auditory fear conditioning. Whereas the mechanisms of postsynaptic LTP at thalamo–LA synapses are well understood, much less is known about the sequence of events mediating presynaptic NMDA receptor-dependent LTP at cortico–LA synapses. Here, we show that presynaptic cortico–LA LTP can be entirely accounted for by a persistent increase in the vesicular release probability. At the molecular level, we found that signaling via the cAMP/PKA pathway is necessary and sufficient for LTP induction. Moreover, by using mice lacking the active-zone protein and PKA target RIM1α (RIM1α−/−), we demonstrate that RIM1α is required for both chemically and synaptically induced presynaptic LTP. Further analysis of cortico–LA synaptic transmission in RIM1α−/− mice revealed a deficit in Ca2+-release coupling leading to a lower baseline release probability. Our results reveal the molecular mechanisms underlying the induction of presynaptic LTP at cortico–LA synapses and indicate that RIM1α-dependent LTP may involve changes in Ca2+-release coupling.
Fermentation of black tea broth (Kombucha): I. Effects of sucrose concentration and fermentation time on the yield of microbial cellulose

The yield and properties of cellulose produced from bacterial fermentation of black tea broth (known as Kombucha) were investigated in this study. The tea broth was fermented naturally over a period of up to 8 days in the presence of sucrose. Tea broth with a sucrose concentration of 90 g/l produced highest yield of bacterial cellulose (66.9%). The thickness and yield of bacterial cellulose increased with fermentation time. The bacterial cellulose production increased correspondingly with increased surface area:depth ratio. Changes in pH were related to the symbiotic metabolic activities of yeasts and acetic acid bacteria, and the counts of both of these in the tea broths were relatively higher than those in the cellulose layer. Findings from this study suggest that the yield of cellulose depends on many factors that need to be optimized to achieve maximum yield.
Different contributions of insulin resistance and beta‐cell dysfunction in overweight Israeli Arabs with IFG and IGT

Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are both intermediate stages that exist between normal glucose tolerance and overt type 2 diabetes. Epidemiological studies demonstrated that the two categories define distinct populations. In this study, we examined the contributions of insulin resistance and beta‐cell dysfunction to both states in overweight subjects of Arab origin.
RETINAL PIGMENT EPITHELIUM PRODUCES MATRIX METALLOPROTEINASES AFTER LASER TREATMENT

Purpose: To evaluate production of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) after panretinal photocoagulation (PRP) of human retinal pigment epithelium (RPE) explants. Methods: Treated explants were subjected to substrate zymography to differentiate MMP-2 from MMP-9 and dot immunoblot analysis to quantify MMP-3 and TIMP activity. Tritiated thymidine uptake by RPE cells was measured to document evidence of cellular division in the laser-treated versus control explants. Results: We detected MMP-2, MMP-3, and TIMP-1. MMP-2 and MMP-3 secretion increased to twice the control values. TIMP decreased until day 4 and then increased by day 6. Tritiated thymidine uptake increased 2.5-fold until day 6, returning to baseline by day 8. Conclusion: PRP disturbs MMP/TIMP balance, inhibiting the initiation and maintenance required for active neovascularization. The efficacy of PRP may be due to changes in the expression pattern of metalloproteinases and inhibitors. This model elucidates the possible contribution of PRP to neovascularization regression by demonstrating the effect of laser on TIMP/MMP balance. The effects of PRP may be much more complex than currently understood and most likely involve more than vascular endothelial growth factor and other ischemia-related factors.
Lateral gene transfer: when will adolescence end?

The scope and impact of horizontal gene transfer (HGT) in Bacteria and Archaea has grown from a topic largely ignored by the microbiological community to a hot‐button issue gaining staunch supporters (on particular points of view) at a seemingly ever‐increasing rate. Opinions range from HGT being a phenomenon with minor impact on overall microbial evolution and diversification to HGT being so rampant as to obfuscate any opportunities for elucidating microbial evolution – especially organismal phylogeny – from sequence comparisons. This contentious issue has been fuelled by the influx of complete genome sequences, which has allowed for a more detailed examination of this question than previously afforded. We propose that the lack of common ground upon which to formulate consensus viewpoints probably stems from the absence of answers to four critical questions. If addressed, they could clarify concepts, reject tenuous speculation and solidify a robust foundation for the integration of HGT into a framework for long‐term microbial evolution, regardless of the intellectual camp in which you reside. Here, we examine these issues, why their answers shape the outcome of this debate and the progress being made to address them.
Current status of estrogen receptors in human breast cancer

In estrogen target tissues and hormone‐dependent tumors, the steroid enters the cells and binds to a cytoplasmic protein called the estrogen receptor (ER). The steroid‐receptor complex then migrates to the nuclei, where it initiates the biochemcial events characteristic of estrogen stimulation. Since ER is absent in tissues not responsive to estrogen, recent studies have asked whether ER assays in human breast cancer tissue might be used to identify those patients likely to respond to endocrine therapy. Data on 436 clinical trials contributed from a dozen centers around the world now clearly indicate that if a patient's tumor does not contain ER, there is virtually no chance of tumor regression following endocrine therapy. A large number of patients can be thus spared unrewarding major endocrine ablative therapy if ER assays are performed routinely. Of tumors with positive ER, 55–60% respond to endocrine therapy. This single piece of data, when coupled with available clinical prognostic factors such as menopausal status, disease free interval, site of the dominant lesion, and especially response to previous hormonal therapies, should permit the practicing oncologist to select or reject endocrine therapy with considerable confidence.
Differences Are Voiced by Two Lyme Camps at a Connecticut Public Hearing on Insurance Coverage of Lyme Disease

In early February 1999, I was called by the Office of the Attorney General of Connecticut and asked to testify at a February 24th public hearing on insurance coverage of Lyme disease. A bill was in the process of development that would mandate Connecticut health insurance companies to pay for long-term intravenous antibiotic therapy for children and adults with Lyme disease. At that time, I didn’t realize that this public hearing was set up to contrast 2 points of view regarding the diagnosis and treatment of Lyme disease, the 2 Lyme camps (a term coined by the lay press to describe the first camp, which include academic-based physicians who use limited antibiotic therapy to treat patients with Lyme disease vs the second camp, which include community-based physicians and patient advocacy groups who believe in open-ended antibiotic therapy to treat patients with Lyme disease). I was invited as a pediatric infectious disease specialist from Connecticut Children’s Medical Center along with Robert T. Schoen, MD, an adult rheumatologist from Yale University School of Medicine. We were requested to represent academic-based physicians. We had both published about the dangers of intravenous antibiotic therapy for patients with presumed Lyme disease.1,2 The purpose of this commentary is to describe the 2 Lyme camps, to summarize the public hearing, and to emphasize that medical public policy should not be determined by advocacy groups unless there is scientific support.3
Diagrammatics in Art and Mathematics

This paper explores two-way relations between visualizations in mathematics and mathematical art, as well as art in general. A collection of vignettes illustrates connection points, including visualizing higher dimensions, tessellations, knots and links, plotting zeros of polynomials, and new and rapidly developing mathematical discipline, diagrammatic categorification.
Gene Expression Profile of the Synovium and Cartilage in a Chronic Arthritis Rat Model

Abstract: Background: Primary osteoarthritis (OA) is a polygenic disease. To investigate the gene expression profile of cartilage and synovium from osteoarthritis and healthy rats using cDNA microarray is beneficial to recognize the pathogenesis of osteoarthritis and provide evidence for gene therapy of osteoarthritis. Objective: The present study aimed to investigate the gene expression profile of the cartilage and synovium of chronic arthritis and healthy rats through cDNA microarray assay, and identify the differentially expressed genes. This study may be helpful for understanding the role of differentially expressed genes in osteoarthritis and the gene polymorphism of osteoarthritis. Methods: A total of 24 male Wistar rats were randomly divided into control group and osteoarthritis group (n = 12 per group). The synovial and cartilage were obtained and total RNA was extracted. cDNA microarray assay was performed to identify the differentially expressed genes, and cluster analysis was conducted. Results and Conclusion: A total of 82 differentially expressed genes were identified, among which 27 were up-regulated and 55 down-regulated. Gene microarray assay is effective to identify differentially expressed genes and may find out novel osteoarthritis associated genes. Multiple genes are involved in the pathogenesis of osteoarthritis. The differentially expressed genes provide important information for further studies on the pathogenesis of osteoarthritis and gene therapy of osteoarthritis.
Evaluation of a decision support system for initiation and control of oral anticoagulation in a randomised trial

Abstract Objectives: To determine whether a computerised decision support system for initiation and control of oral anticoagulant treatment improves quality of anticoagulant control achieved by trainee doctors. Design: Randomised controlled trial. Setting: District general hospital in North London. Subjects: 148 inpatients requiring start of warfarin treatment. Interventions: Management by trainee doctors (to achieve therapeutic range of international normalised ratio of 2 to 3) with indirect assistance from computerised decision support system (intervention group) or without such assistance (control group). Main outcome measures: Median time to therapeutic range, stable dose, and first pseudoevent (excessive international normalised ratio after therapeutic range has been reached) and person time spent in the therapeutic range. Results: 72 patients were randomised to the intervention group and 76 to control group. Median time to reach international normalised ratio of ≥2 was not significantly different in the two groups (3 days). Median time to achieve a stable dose was significantly lower in intervention group than in controls (7 days v 9 days, P=0.01) without excessive overtreatment or undertreatment with anticoagulant. Patients in intervention group spent greater proportion of time in therapeutic range, both as inpatients (59% v 52%) and outpatients (64% v 51%). Conclusion: The computerised decision support system was safe and effective and improved the quality of initiation and control of warfarin treatment by trainee doctors. Key messages The quality of control of warfarin doses during initiation and maintenance of oral anticoagulation is generally poor We investigated whether a computerised decision support system for initiation and control of oral anticoagulation improved quality of anticoagulant control achieved by trainee doctors The median time to achieve a stable dose was significantly lower in the group assisted by the decision support system than in controls, without excessive overtreatment or undertreatment with anticoagulant Patients in the group with the decision aid spent more time within the therapeutic range both as inpatients and outpatients The computerised decision support system was safe and effective and improved quality of initiation and control of warfarin treatment by trainee doctors
Antibody Humanization Using Monovalent Phage Display*

Antibody humanization often requires the replacement of key residues in the framework regions with corresponding residues from the parent non-human antibody. These changes are in addition to grafting of the antigen-binding loops. Although guided by molecular modeling, assessment of which framework changes are beneficial to antigen binding usually requires the analysis of many different antibody mutants. Here we describe a phage display method for optimizing the framework of humanized antibodies by random mutagenesis of important framework residues. We have applied this method to humanization of the anti-vascular endothelial growth factor murine monoclonal antibody A4.6. 1. Affinity panning of a library of humanized A4.6. 1 antibody mutants led to the selection of one variant with greater than 125-fold enhanced affinity for antigen relative to the initial humanized antibody with no framework changes. A single additional mutation gave a further 6-fold improvement in binding. The affinity of this variant, 9.3 nm, was only 6-fold weaker than that of a murine/human chimera of A4.6. 1. This method provides a general means of rapidly selecting framework mutations that improve the binding of humanized antibodies to their cognate antigens and may prove an attractive alternative to current methods of framework optimization based on cycles of site-directed mutagenesis.
Java Security Anti-Patterns: The Unguarded Layer Switch

According to Gamma et al. Patterns (1995) are known as commonly used solutions to common problems. AntiPatterns in contrast, as described by Brown et al. (1998) are best described as solutions to problems that generates additional negative consequences to the already existing problem. Causes for anti-patterns are on the one hand insufficient knowledge in applying a design pattern or experience in matching a problem to a pattern which leads to an anti-pattern via mismatch. The architectural design of program languages has to scale not only in terms of performance; it also has to be appropriate to a broad range of use cases, especially security issues. Java is a commonly used language which solves according to Gosling et al. (1996) the problems of platform differences and software distribution in an elegant way, therefore giving a solid foundation for large scale application development. This paper provides an approach to detect implementation in the inner core of the java libraries allowing low-level crashes. The paper provides an approach that was already proven successful in hardening Suns java implementation in the transition from JDK 1.4. 1_01 to 1.4. 1_02.
Effect of Riluzole on Cytosolic Ca2+ Increase in Human Osteosarcoma Cells

In human osteosarcoma MG63 cells, the effect of the neuroprotective drug riluzole on the intracellular Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) was measured using fura-2. Riluzole (50–500 µmol/l) caused a rapid and sustained plateau increase in [Ca<sup>2+</sup>]<sub>i</sub> in a concentration-dependent manner (EC<sub>50</sub> = 150 µmol/l). The riluzole-induced rise in [Ca<sup>2+</sup>]<sub>i</sub> was prevented by 58 and 20% by extracellular Ca<sup>2+</sup> removal and nifedipine, respectively, but was not changed by La<sup>3+</sup> and verapamil. In Ca<sup>2+</sup>-free medium, thapsigargin, an inhibitor of the endoplasmic reticulum (ER) Ca<sup>2+</sup>-ATPase, caused a monophasic increase in [Ca<sup>2+</sup>]<sub>i</sub>, after which the increasing effect of riluzole on [Ca<sup>2+</sup>]<sub>i</sub> was attenuated by 84%; also, pretreatment with riluzole abolished the thapsigargin-induced [Ca<sup>2+</sup>]<sub>i</sub> increase. U73122, an inhibitor of phospholipase C, abrogated the ATP (but not riluzole)-induced rise in [Ca<sup>2+</sup>]<sub>i</sub>. A low concentration (6 µmol/l) of riluzole selectively potentiated the bradykinin (but not ATP and histamine)-induced increase in [Ca<sup>2+</sup>]<sub>i</sub>. These results suggest that riluzole rapidly increases [Ca<sup>2+</sup>]<sub>i</sub> by stimulating both the extracellular Ca<sup>2+</sup> influx via a nifedipine-sensitive pathway and intracellular Ca<sup>2+</sup> release from the ER via an as yet unidentified mechanism(s).