Miracle-dz/UniFAR-FTUs huggingface dataset:
Gendered Pathways: How Mathematics Ability Beliefs Shape Secondary and Postsecondary Course and Degree Field Choices

Do mathematics ability beliefs explain gender gaps in the physical science, engineering, mathematics, and computer science fields (PEMC) and other science fields? We leverage U.S. nationally representative longitudinal data to estimate gendered differences in girls' and boys' perceptions of mathematics ability with the most difficult or challenging material. Our analyses examine the potentially interacting effects of gender and these ability beliefs on students' pathways to scientific careers. Specifically, we study how beliefs about ability with challenging mathematics influence girls' and boys' choices to pursue PEMC degrees, evaluating educational milestones over a 6-year period: advanced science course completion in secondary school and postsecondary major retention and selection. Our findings indicate even at the same levels of observed ability, girls' mathematics ability beliefs under challenge are markedly lower than those of boys. These beliefs matter over time, potentially tripling girls' chances of majoring in PEMC sciences, over and above biological science fields, all else being equal. Implications and potential interventions are discussed.
Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosis

Anti nuclear (ANA) immunomorphological patterns such as multiple nuclear dots (MND) and rim-like/membranous (RL/M) are considered highly specific but little sensitive for primary biliary cirrhosis (PBC) diagnosis. To evaluate frequency and clinical significance of MND and RL/M in PBC patients when investigated at the level of immunoglobulin G isotypes. MND and RL/M pattern have been tested in 141 PBC sera and 230 pathological controls using HEp-2 cells as substrate and anti- total IgG and individuaI IgG subclasses (IgG1, IgG2, IgG3, IgG4) as specific antisera. One hundred and fourteen of 141 (80%) PBC patients had RL/M or MND pattern when IgG subclasses were used as revealing reagents (vs. 34% when anti total IgG were used, p < 0.0001). The prevalent isotype was IgG1 for RL/M, and IgG2 for MND pattern. None of controls was positive. No clinical differences in terms of severity and outcome of disease have been observed in PBC patients positive for MND and RL/M when investigated with IgG isotypes. The research for RL/M and MND pattern at level of IgG isotype determines a wide gain in terms of sensitivity without a loss of specificity. In Italian PBC patients MND and RL/M pattern did not seem to characterize any subgroup of patients with a poorer prognosis.
Analysis of the radiation characteristics of CRLH LWAs around broadside

A study of the characteristics of lossy composite right/left-handed (CRLH) leaky-wave antennas (LWAs) is presented. It is analytically shown that the fulfilment of the Heaviside condition in this media leads to an undistorted phase constant, a frequency-independent attenuation constant and a purely real characteristic impedance. In addition, closed-formed expressions for the efficiency and radiation rate of the antenna, valid around the transition frequency, are derived. It is found that the antenna efficiency depends on the individual efficiencies of the series and shunt branches of the unit cell, which are decoupled. Also, it is shown that the simultaneous presence of series and shunt radiation resistors is not necessary to obtain radiation at broadside. However, in this case the antenna efficiency will always be below of 50%. Full-wave simulations results are included to demonstrate the validity of the developed circuit-based theory.
Chronic and intensive bottom trawling impairs deep-sea biodiversity and ecosystem functioning

Significance Deep-sea ecosystem processes play a key role in global functioning of the planet. These functions are largely dependent upon deep-sea biodiversity. Industrial fisheries, after the depletion of fish stocks and destruction of the marine habitats on continental shelves, are now rapidly moving deeper into the ocean interior. We show here that bottom trawling along continental slopes has a major impact on deep-sea sedimentary ecosystems, causing their degradation and infaunal depauperation. Deep-sea fisheries, indeed, cause the collapse of benthic biodiversity and ecosystem functions, with potential consequences on the biogeochemical cycles. These findings support the claim of immediate actions for a sustainable management of fisheries in deep-sea environments. Bottom trawling has many impacts on marine ecosystems, including seafood stock impoverishment, benthos mortality, and sediment resuspension. Historical records of this fishing practice date back to the mid-1300s. Trawling became a widespread practice in the late 19th century, and it is now progressively expanding to greater depths, with the concerns about its sustainability that emerged during the first half of the 20th century now increasing. We show here that compared with untrawled areas, chronically trawled sediments along the continental slope of the north-western Mediterranean Sea are characterized by significant decreases in organic matter content (up to 52%), slower organic carbon turnover (ca. 37%), and reduced meiofauna abundance (80%), biodiversity (50%), and nematode species richness (25%). We estimate that the organic carbon removed daily by trawling in the region under scrutiny represents as much as 60–100% of the input flux. We anticipate that such an impact is causing the degradation of deep-sea sedimentary habitats and an infaunal depauperation. With deep-sea trawling currently conducted along most continental margins, we conclude that trawling represents a major threat to the deep seafloor ecosystem at the global scale.
PRIMARY NONFUNCTION: Is THERE A CONTRIBUTION FROM THE BACK TABLE BATH?

A persistent problem in orthotopic liver transplantation (OLT) is primary nonfunction (PNF) of the hepatic allograft. In most instances the cause of the failure is unknown. In an attempt to minimize these graft failure, modifications in the procurement and operative procedure have been investigated. One change in the procedure at the University of Nebraska Medical Center has been the monitoring of the temperature of the fluid in the back table bath during preparation of the donor liver. Our initial procedure involved creating an ice slurry of lactated Ringer's solution and ice slush in which the donor liver was then prepared. The temperature of this ice slurry was retrospectively found to be from –3°C to –1°C (group I). In this group there was a higher-than-expected incidence of PNF. To investigate whether the temperature of the back table bath influenced the incidence of PNF, beginning with transplant No. 42 the preparation of the back table bath was modified. The bath was created by adding a small amount of PlasmaLyte slush to 2 L of PlasmaLyte (group II). The temperature of the bath was maintained at 2–4°C. Data were collected on 100 consecutive liver transplants. All transplants were performed using standard techniques, the operation for the two groups differing only as described above. Transaminase levels were followed as an index of the allograft function and were expected to begin to normalize within 2–3 days after transplantation. While both groups display this trend, transaminase levels in group II were significantly lower postoperatively than group I levels (P<0.05). Preoperative values were similar. There were 7 PNFs in group I; 0 in group.
3Di DC-DC Buck Micro Converter with TSVs, Grind Side Inductors, and Deep Trench Decoupling Capacitors in 32nm SOI CMOS

High performance processors and ASICs typically require multiple voltages and multi-domain voltage controls across the die. Conventional approaches distribute the voltage regulation elements between the processor, the package laminate, and the printed circuit board. We propose an alternative approach where the voltage regulator is embodied in a 3D configuration such that the inductor, capacitor and the switches are formed on a separate silicon chip sandwiched between the processor and the laminate. Due to the close proximity of regulator to the processor, this approach can enable granular voltage domains, while minimizing disruptions to the processor layout. We describe a 4-f DC-DC buck converter fabricated on 32nm SOI wafers using TSVs to connect the switches on the front-side of the wafer to the inductors on the grind-side. The process builds on a 32nm SOI CMOS flow, adding deep trench (DT) capacitors and TSV's. Down conversion from a standard I/O voltage under various load conditions was evaluated, and an efficiency of 77% was achieved.
Distributed video coding with adaptive selection of hash functions

We address the compression efficiency of feedback-free and hash-check distributed video coding, which generates and transmits a hash code of a source information sequence. The hash code helps the decoder perform a motion search. A hash collision is a special case in which the hash codes of wrongly reconstructed information sequences occasionally match the hash code of the source information sequence. This deteriorates the quality of the decoded image greatly. In this paper, the statistics of hash collision are analyzed to help the codec select the optimal trade-off between the probability of hash collision and the length of the hash code, according to the principle of rate-distortion optimization. Furthermore, two novel algorithms are proposed: (1) the nonzero prefix of coefficients (NPC), which indicates the count of nonzero coefficients of each block for the second algorithm, and also saves 8.4% bitrate independently; (2) the adaptive selection of hash functions (AHF), which is based on the NPC and saves a further 2%–6% bitrate on average. The detailed optimization of the parameters of AHF is also presented.
The platelet release reaction: just when you thought platelet secretion was simple

Purpose of reviewIn response to agonists produced at vascular lesions, platelets release a host of components from their three granules: dense core, alpha, and lysosome. This releasate activates other platelets, promotes wound repair, and initiates inflammatory responses. Although widely accepted, the specific mechanisms underlying platelet secretion are only now coming to light. This review focuses on the core machinery required for platelet secretion. Recent findingsProteomic analyses have provided a catalog of the components released from activated platelets. Experiments using a combination of in-vitro secretion assays and knockout mice have led to assignments of both vesicle-soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (v-SNARE) and target membrane SNARE to each of the three secretion events. SNARE knockout mice are also proving to be useful models for probing the role of platelet exocytosis in vivo. Other studies are beginning to identify SNARE regulators, which control when and where SNAREs interact during platelet activation. SummaryA complex set of protein–protein interactions control the membrane fusion events required for the platelet release reaction. SNARE proteins are the core elements but the proteins that control SNARE interactions represent key points at which platelet signaling cascades could affect secretion and thrombosis.
The generation of myricetin–nicotinamide nanococrystals by top down and bottom up technologies

Myricetin–nicotinamide (MYR–NIC) nanococrystal preparation methods were developed and optimized using both top down and bottom up approaches. The grinding (top down) method successfully achieved nanococrystals, but there were some micrometer range particles and aggregation. The key consideration of the grinding technology was to control the milling time to determine a balance between the particle size and distribution. In contrast, a modified bottom up approach based on a solution method in conjunction with sonochemistry resulted in a uniform MYR–NIC nanococrystal that was confirmed by powder x-ray diffraction, scanning electron microscopy, dynamic light scattering, and differential scanning calorimeter, and the particle dissolution rate and amount were significantly greater than that of MYR–NIC cocrystal. Notably, this was a simple method without the addition of any non-solvent. We anticipate our findings will provide some guidance for future nanococrystal preparation as well as its application in both chemical and pharmaceutical area.
Managerial Economics: An Analysis of Business Issues

Introduction. 1. The Definition and Scope of Managerial Economics PART I: THE FIRM. 2. Business Objectives and Basic Models of the Firm 3. The Boundaries of the Firm 4. Ownership and Control of the Firm 5. The Multinational Enterprise PART II: THE MARKET ENVIRONMENT. 6. Consumer Behaviour 7. Demand and Elasticity 8. Estimating and Forecasting Demand 9. Production and the Determination of Costs 10. Elementary Models of Competitive Structure 11. The Five Forces Approach of Competitive Structure 12. Risk and Uncertainty PART III: BUSINESS DECISIONS. 13. Game Theory and Oligopoly 14. Pricing in Theory 15. Pricing in Practice 16. Non-Price Competition and the Marketing Mix 17. Investment Decisions and the Cost of Capital 18. Economics and the Analysis of Business Strategy 19. Managerial Economics: The Information Sector and the Internet PART IV: PUBLIC POLICY. 20. The Economics of Regulated Industries 21. Competition Policy
Free school fruit: can an extra piece of fruit every school day contribute to the prevention of future weight gain? A cluster randomized trial

Background Several school fruit programs are initiated with the aim to improve diet and thereby contribute to reduce the prevalence of overweight. To date, no published studies have demonstrated that school fruit schemes do prevent overweight. Objective The aim of the present study was to assess if increased consumption of fruits and vegetables, due to free school fruit, have an impact on future weight status. Design An intervention study including 10- to 12-year-old children from nine schools in two Norwegian counties (Hedmark and Telemark) participating in the Norwegian School Fruit Program for free during the school year 2001/2002 and children from 29 control schools. Follow-up studies were performed in 2005 and 2009. The cohort includes 1950 pupils (984 boys, 966 girls) at baseline, 1,602 participants in 2005 and 320 participants in the 2009 survey, of which 282 also had participated in 2005. Results In 2005, there was no significant difference between the free fruit group and the control group regarding weight status, Body mass index, or perceived weight status. In 2009, a significant difference in prevalence of overweight was observed (15% vs. 25%, p=0.04). In the crude logistic analysis, the OR for being overweight was 0.52 (95% CI: 0.28–0.97) for the intervention group compared to controls. When adjusting for school, sex, grade level and parental education, the association was no longer statistically significant. Conclusions These results indicate that free school fruit might contribute to prevent future excessive weight gain. However, the study results are limited by low participation rate.
A large Legionnaires' disease outbreak in Pamplona, Spain: early detection, rapid control and no case fatality

SUMMARY An outbreak of Legionnaire's disease was detected in Pamplona, Spain, on 1 June 2006. Patients with pneumonia were tested to detect Legionella pneumophila antigen in urine (Binax Now; Binax Inc., Scarborough, ME, USA), and all 146 confirmed cases were interviewed. The outbreak was related to district 2 (22 012 inhabitants), where 45% of the cases lived and 50% had visited; 5% lived in neighbouring districts. The highest incidence was found in the resident population of district 2 (3/1000 inhabitants), section 2 (14/1000). All 31 cooling towers of district 2 were analysed. L. pneumophila antigen (Binax Now) was detected in four towers, which were closed on 2 June. Only the strain isolated in a tower situated in section 2 of district 2 matched all five clinical isolates, as assessed by mAb and two genotyping methods, AFLP and PFGE. Eight days after closing the towers, new cases ceased appearing. Early detection and rapid coordinated medical and environmental actions permitted immediate control of the outbreak and probably contributed to the null case fatality.
Structural Insight into the Mechanisms of Transport across the Salmonella enterica Pdu Microcompartment Shell*

Bacterial microcompartments are a functionally diverse group of proteinaceous organelles that confine specific reaction pathways in the cell within a thin protein-based shell. The propanediol utilizing (Pdu) microcompartment contains the reactions for metabolizing 1,2-propanediol in certain enteric bacteria, including Salmonella. The Pdu shell is assembled from a few thousand protein subunits of several different types. Here we report the crystal structures of two key shell proteins, PduA and PduT. The crystal structures offer insights into the mechanisms of Pdu microcompartment assembly and molecular transport across the shell. PduA forms a symmetric homohexamer whose central pore appears tailored for facilitating transport of the 1,2-propanediol substrate. PduT is a novel, tandem domain shell protein that assembles as a pseudohexameric homotrimer. Its structure reveals an unexpected site for binding an [Fe-S] cluster at the center of the PduT pore. The location of a metal redox cofactor in the pore of a shell protein suggests a novel mechanism for either transferring redox equivalents across the shell or for regenerating luminal [Fe-S] clusters.
Eculizumab for dense deposit disease and C3 glomerulonephritis.

BACKGROUND AND OBJECTIVES The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the alternative complement pathway. Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, may prove beneficial. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS In this open-label, proof of concept efficacy and safety study, six subjects with dense deposit disease or C3 glomerulonephritis were treated with eculizumab every other week for 1 year. All had proteinuria >1 g/d and/or AKI at enrollment. Subjects underwent biopsy before enrollment and repeat biopsy at the 1-year mark. RESULTS The subjects included three patients with dense deposit disease (including one patient with recurrent dense deposit disease in allograft) and three patients with C3 glomerulonephritis (including two patients with recurrent C3 glomerulonephritis in allograft). Genetic and complement function testing revealed a mutation in CFH and MCP in one subject each, C3 nephritic factor in three subjects, and elevated levels of serum membrane attack complex in three subjects. After 12 months, two subjects showed significantly reduced serum creatinine, one subject achieved marked reduction in proteinuria, and one subject had stable laboratory parameters but histopathologic improvements. Elevated serum membrane attack complex levels normalized on therapy and paralleled improvements in creatinine and proteinuria. CONCLUSIONS Clinical and histopathologic data suggest a response to eculizumab in some but not all subjects with dense deposit disease and C3 glomerulonephritis. Elevation of serum membrane attack complex before treatment may predict response. Additional research is needed to define the subgroup of dense deposit disease/C3 glomerulonephritis patients in whom eculizumab therapy can be considered.
Interobserver variability in assessing dysplasia and architecture in colorectal adenomas: a multicentre Canadian study

Aims Following the introduction of colorectal cancer screening programmes throughout Canada, it became necessary to standardise the diagnosis of colorectal adenomas. Canadian guidelines for standardised reporting of adenomas were developed in 2011. The aims of the present study were (a) to assess interobserver variability in the classification of dysplasia and architecture in adenomas and (b) to determine if interobserver variability could be improved by the adoption of criteria specified in the national guidelines. Methods An a priori power analysis was used to determine an adequate number of cases and participants. Twelve pathologists independently classified 40 whole-slide images of adenomas according to architecture and dysplasia grade. Following a wash-out period, participants were provided with the national guidelines and asked to reclassify the study set. Results At baseline, there was moderate interobserver agreement for architecture (K=0.4700; 95% CI 0.4427 to 0.4972) and dysplasia grade (K=0.5680; 95% CI 0.5299 to 0.6062). Following distribution of the guidelines, there was improved interobserver agreement in assessing architecture (K=0.5403; 95% CI 0.5133 to 0.5674)). For dysplasia grade, overall interobserver agreement remained moderate but decreased significantly (K=0.4833; 95% CI 0.4452 to 0.5215). Half of the cases contained high-grade dysplasia (HGD). Two pathologists diagnosed HGD in ≥75% of cases. Conclusions The improvement in interobserver agreement in classifying adenoma architecture suggests that national guidelines can be useful in disseminating knowledge, however, the variability in the diagnosis of HGD, even following guideline review suggests the need for ongoing knowledge-transfer exercises.
Information, Uncertainty and Sudden Stops in Real Investment

The concept of Knightian uncertainty has been used liberally to both describe the current financial crisis and to explain the subsequent Great Recession of 2007-09. This paper lays out a simple two-period model with both risk and uncertainty in financial intermediation technology, to investigate more precisely how unanticipated increases in uncertainty might bring about a significant downturn in the real economy. We compare similar economies with and without uncertainty and demonstrate how an increase in the amount of uncertainty regarding the role of financial intermediaries can have a dramatic effect on the real economy. In addition, we explore how the unanticipated arrival of information about they quality of financial intermediaries, in an environment with Knightian uncertainty, can also have a dramatic negative effect on the real economy regardless of the precise nature of that information. ∗Stern School of Business, New York University, and NBER; david.backus@nyu.edu. †Stern School of Business, New York University, and NBER; zin@nyu.edu.
Adrenomedullin as a therapeutic target in angiogenesis

Importance of the field: Hypoxia, a frequent characteristic in the microenvironment of solid tumors, leads to adrenomedullin (AM) upregulation through the hypoxia inducible factor-1 pathway, explaining its high expression in a variety of malignant tissues. AM is believed to play an important role in tumor progression and angiogenesis in many cancers. Therefore, it could become a new therapeutic target. Areas covered in this review: We performed a review of the literature based on published data to highlight AM's critical roles in tumor cell growth and cancer invasiveness, and its involvement in tumor angiogenesis through promotion of recruitment of hematopoietic progenitors, vascular morphogenesis, and blood vessel stabilization and maturation. Inhibition of AM has antitumoral effects linked to antiangiogenic effects but in some cases also to direct antiproliferative activity on cancer cells. Several studies demonstrated that systemic inhibition of AM receptors was well tolerated in murine models. What the reader will gain: The goal of this review is to inform readers about the role of AM in tumor angiogenesis and cancer progression and, therefore, about its possible place as a new therapeutic target. Take home message: Taken together, these data support targeting the AM pathway as a new potential therapy in cancer, complementary to other existing treatments.