Miracle-dz/UniFAR-FTUs huggingface dataset:
Transition from treatment to survivorship: effects of a psychoeducational intervention on quality of life in breast cancer survivors.

PURPOSE/OBJECTIVES To examine the effectiveness of a psychoeducational intervention on quality of life (QOL) in breast cancer survivors in post-treatment survivorship. DESIGN A randomized controlled trial. SETTING An academic center collaborating with a regional cancer center in the southeastern United States. SAMPLE 256 breast cancer survivors. METHODS Women were randomly assigned to the experimental or wait control group. The Breast Cancer Education Intervention (BCEI) study was delivered in three face-to-face sessions and five monthly follow-up sessions (three by telephone and two in person). The control group received four monthly attention control telephone calls and the BCEI at month 6. Data were collected at baseline, three and six months after the BCEI for the experimental group, and one month after the BCEI (at month 7) for the wait control group. MAIN RESEARCH VARIABLES Primary endpoints were overall QOL and physical, psychological, social, and spiritual well-being. FINDINGS No differences in QOL were reported at baseline between groups. The experimental group reported improved QOL at three months, whereas the wait control group reported a significant decline in QOL. The experimental group reported continued maintenance of QOL at six months. Although the wait control group reported improved QOL at six months, significant differences continued to exist between the groups. CONCLUSIONS The BCEI was an effective intervention in improving QOL during the first year of breast cancer survivorship. Treatment effects were durable over time. IMPLICATIONS FOR NURSING Post-treatment survivorship has not been empirically studied to a large degree. The BCEI is one of the few interventions demonstrating effectiveness among survivors after primary treatment, suggesting that oncology nurses may be uniquely positioned to provide safe passage using education and support.
Exploring Environmental Variation in Residential Care Facilities for Older People

Objective: The aim of this study was to explore variation in environmental quality in Swedish residential care facilities (RCFs) using the Swedish version of the Sheffield Care Environment Assessment Matrix (S-SCEAM). Background: Well-designed physical environments can positively impact on health and well-being among older persons with frail health living in RCFs and are essential for supporting person-centered care. However, the evidence base for informing the design of RCFs is weak, partly due to a lack of valid and reliable instruments that could provide important information on the environmental quality. Methods: Twenty RCFs were purposively sampled from several regions, varying in their building design, year of construction, size, and geographic location. The RCFs were assessed using S-SCEAM and the data were analyzed to examine variation in environmental quality between and within facilities. Results: There was substantial variation in the quality of the physical environment between and within RCFs, reflected in S-SCEAM scores related to specific facility locations and with regard to domains reflecting residents’ needs. In general, private apartments and dining areas had high S-SCEAM scores, while gardens had lower scores. Scores on the safety domain were high in the majority of RCFs, whereas scores for cognitive support and privacy were relatively low. Conclusions: Despite high building standard requirements, the substantial variations regarding environmental quality between and within RCFs indicate the potential for improvements to support the needs of older persons. We conclude that S-SCEAM is a sensitive and unique instrument representing a valuable contribution to evidence-based design that can support person-centered care.
The Identification of a Second Cofilin Binding Site on Actin Suggests a Novel, Intercalated Arrangement of F-actin Binding*

The cofilins are members of a protein family that binds monomeric and filamentous actin, severs actin filaments, and increases monomer off-rate from the pointed end. Here, we characterize the cofilin-actin interface. We confirm earlier work suggesting the importance of the lower region of subdomain 1 encompassing the N and C termini (site 1) in cofilin binding. In addition, we report the discovery of a new cofilin binding site (site 2) from residues 112–125 that form a helix toward the upper, rear surface of subdomain 1 in the standard actin orientation (Kabsch, W., Mannherz, H. G., Suck, D., Pai, E. F., and Holmes, K. C. (1990) Nature 347, 37–44). We propose that cofilin binds “behind” one monomer and “in front” of the other longitudinally associated monomer, accounting for the fact that cofilin alters the twist in the actin (McGough, A., Pope, B., Chiu, W., and Weeds, A. (1997) J. Cell Biol. 138, 771–781). The characterization of the cofilin-actin interface will facilitate an understanding of how cofilin severs and depolymerizes filaments and may shed light on the mechanism of the gelsolin family because they share a similar fold with the cofilins (Hatanaka, H., Ogura, K., Moriyama, K., Ichikawa, S., Yahara, I., and Inagiki, F. (1996) Cell 85, 1047–1055).
Supplémentation en colza ou en lin de rations à base d'herbe chez la vache laitière durant deux lactations consécutives: Effets sur les performances zootechniques et la composition fine en acides gras du lait

L’apport de graines oleagineuses dans la ration de la vache laitiere pendant 1 a 3 mois pourrait ameliorer la qualite nutritionnelle du lait, mais egalement penaliser dans certains cas les performances zootechniques. Peu de donnees sont disponibles sur les effets de ces strategies alimentaires sur de plus longues periodes. L’objectif de cette these est de quantifier au cours de 2 lactations consecutives, les effets de supplementations en lin ou en trois differentes formes de colza de rations a base d’herbe conservee en hiver et pâturee en ete sur les performances zootechniques de la vache laitiere et la composition fine en acides gras du lait. Les effets des supplements etudies persistent au sein de chaque periode (hiver et ete) et sont repetables d’un ete a l’autre. Ils sont par ailleurs similaires a ceux observes lors d’etudes de duree plus courte (1 a 3 mois). Ces strategies ne permettent pas d’ameliorer les performances zootechniques et diminuent parfois le taux proteique du lait, notamment en hiver. Toutefois, elles reduisent les teneurs du lait en acides gras satures au profit de l’acide oleique et, dans le cas du lin de l’acide α-linolenique. Ces modifications peuvent etre considerees comme une amelioration de la qualite nutritionnelle du lait. Cependant, le lin extrude et le tourteau de colza gras augmentent les acides gras trans et les supplements diminuent souvent l’acide rumenique du lait au pâturage. La distribution des isomeres des acides gras insatures cis et trans du lait depend du type de graine et du niveau d’amidon de la ration, mais pas de la forme d’apport du colza, qui influence toutefois l’amplitude des effets observes. Par ailleurs, l’analyse detaillee du profil en acides gras du lait a permis de mieux comprendre le metabolisme des acides linoleiques et linoleniques conjugues, en lien avec la lipogenese mammaire.
Theory within a Modern evolutionary framework

as this quotation indicates, Charles Darwin was an attachment theorist. Although he focused on “society” (instead of significant others) and “comrades” (instead of attachment figures), Darwin was the first scientist to appreciate the full extent to which human social nature is a product of selection pressures. John Bowlby, who not only admired Darwin’s theoretical vision but was one of his biographers (see Bowlby, 1991), spent most of his brilliant career treading the intellectual path that Darwin started paving. Integrating ideas from Darwin’s theory of evolution by natural selection, object relations theory, control systems theory, evolutionary biology, and the fields of ethology and cognitive psychology, Bowlby (1969/1982, 1973, 1980) developed a grand synthesis of social and personality development across the lifespan, which is now known as attachment theory. One reason why attachment theory is so generative and prominent today is its deep intellectual ties to fundamental principles of evolution. In many respects, however, attachment theory and its adherents have not kept up with developments in evolutionary biology. In fact, beyond acknowledging that attachment behavior evolved via natural selection to facilitate the survival of infants in the environment of evolutionary adaptedness (EEA), surprisingly little attachment-related research and writing addresses the importance of either reproduction and reproductive fitness as the target of natural selection or the role of environmental conditions, including parenting, in regulating the development of reproductive strategies. These are critical issues that we address in this chapter. As we shall see, attachment theory is one of a handful of major middle-level evolutionary theoChapter 5
Aide à la prise de décision stratégique : détection de données pertinentes de sources numériques sur Internet

Le domaine de notre recherche est la decision strategique au sein des organisations. Plus precisement il s'agit de l'aide a la prise de decision strategique et de la problematique de l'acquisition des informations utiles pour de telles decisions. D'un cote les ‘informations de terrain' issus des contacts entre personnes, des reunions professionnelles, etc. demeurent essentielles pour les dirigeants. D'un autre cote les journaux quotidiens nationaux et internationaux fournissent un volume considerable de donnees que l'on peut qualifier de donnees brutes (Raw data). Mais, outre ces sources classiques, le recueil des informations a evolue de facon considerable avec l'avenement des technologies de l'information et notamment de l'Internet pour ce qui concerne dans notre recherche. Nous avons choisi le domaine concernant l'acquisition des informations de terrain fournies par les journaux nationaux quotidiens : les journaux quotidiens colombiens pour ce qui concernera notre etude empirique. Pour acquerir cette information nous avons propose sur la base d'une recherche du type « Action Design Research », de concevoir, de construire et d'experimenter un artefact permettant de detecter des signaux faibles potentiels issus des donnees extraites d'Internet et qui aideraient les dirigeants de l'entreprise a decouvrir et comprendre leur environnement. L'artefact a ete concu et construit en deux phases utilisant des concepts theoriques lies a la surcharge de donnees, a la veille strategique notamment la VAS-IC® (Veille Anticipative Strategique – Intelligence Collective) et sur les caracteristiques souhaitables des systemes informatises d'aide a la decision strategique. Apres sa construction, l'artefact a ete experimente sur un terrain permettant d'evaluer son effectivite. Cette experimentation a permis d'ameliorer nos connaissances sur la pertinence des donnees numeriques dans le processus de la prise de la decision. Les decideurs impliques ont egalement pu d'integrer des nouvelles pratiques adaptees a leurs besoins d'information.
Ganglioside mimicry as a cause of Guillain–Barré syndrome

Purpose of reviewCampylobacter jejuni is the most frequent agent of antecedent infection in an axonal variant of Guillain–Barré syndrome, acute motor axonal neuropathy, and anti-GM1 or anti-GD1a IgG antibody is also associated with acute motor axonal neuropathy. Molecular mimicry has been found between human GM1 ganglioside and the lipo-oligosaccharide of C. jejuni isolated from an acute motor axonal neuropathy patient. Progress has been made in Guillain–Barré syndrome research, especially on acute motor axonal neuropathy subsequent to C. jejuni enteritis. Recent findingsSensitization of rabbits with C. jejuni lipo-oligosaccharide, as well as GM1, induced the production of anti-GM1 IgG antibody, and the subsequent development of acute flaccid paralysis. Pathological changes in rabbit peripheral nerves were identical to those seen in human acute motor axonal neuropathy. These findings provide conclusive evidence that molecular mimicry is a cause of human autoimmune disease. Ganglioside-like lipo-oligosaccharide is synthesized by sialyltransferase Cst-II, N-acetylgalactosaminyl-transferase CgtA, and galactosyltransferase CgtB. There is a strong association between the simultaneous presence of these genes and Guillain–Barré syndrome-associated C. jejuni strains. Knockout mutants of C. jejuni genes involved in lipo-oligosaccharide sialylation had reduced reactivity with anti-GM1 sera from Guillain–Barré syndrome patients, and did not induce an anti-GD1a IgG antibody response in mice. Lipo-oligosaccharide biosynthesis genes appear to be essential for the induction of anti-GM1 or anti-GD1a IgG antibody and the subsequent development of acute motor axonal neuropathy. SummaryThe concept that carbohydrate mimicry causes autoimmune disease provides a clue to the resolution of the pathogenesis of other immune-mediated diseases.
Automated detection of cardiac health condition using linear techniques

Coronary Artery Disease (CAD) is the basic source for various cardiac diseases such as Myocardial Infraction (MI) or Heart Attack (HA), Heart Failure (HF) and Ischemic Heart Disease (IHD). Detection of CAD in the early stages and treatment for the same will help in preventing from continuing further. However earlier and precise recognition of CAD from Electrocardiogram (ECG) signals using manual recognition is not an easy job to perform. Thus computer aided techniques are essential for the automatic classification of CAD condition. This work proposes an automated classification of normal and CAD conditions of ECG using linear techniques. In this method normal and CAD ECG beats are de-noised using Discrete Wavelet Transform (DWT) technique. Feature extraction of ECG signals is achieved by Discrete Cosine Transform (DCT). Dimensionality reduction of data set is done by Principle Component Analysis (PCA). The resulting PCA features are partitioned using Cross Validation Partition for the classification purpose. Normal and CAD ECG signals are classified by k-Nearest Neighbor (k-NN) classifier and obtained results are compared with Support Vector Machine (SVM) classifier.
Lidocaine converts acute vagally associated atrial fibrillation to sinus rhythm in German Shepherd dogs with inherited arrhythmias.

BACKGROUND Lidocaine is most frequently used to treat ventricular arrhythmias. However, lidocaine may have an antiarrhythmic effect for certain supraventricular arrhythmias. HYPOTHESIS We hypothesized that lidocaine would be effective in converting experimentally induced atrial fibrillation (AF) to sinus rhythm and that a decrease in the dominant frequency (DF) and an increase in the organization as judged by the spectral entropy (SE) would occur over the course of the conversion. ANIMALS Seven German Shepherd (GS) Dogs. METHODS Dogs were anesthetized with fentanyl and pentobarbital. AF was induced with standard pacing protocols while left and right atrial monophasic action potentials (MAP) were recorded. The power spectra from the MAP recordings were analyzed to determine DF and SE during treatment with boluses of 2 mg/kg lidocaine. RESULTS Lidocaine converted AF to sinus rhythm in all dogs and all episodes (n = 19). Conversion time was 27-87 seconds. After atropine, sustained AF was not induced; however, 5 episodes of atrial tachycardia resulted, and 3 were converted with lidocaine. Frequency domain analysis of 12 conversion sequences showed that left and right DF of the MAP signals decreased from the time of injection to conversion to sinus rhythm (P < .001). Mean SE indicated a gradient between the left and right atria (P = .003) that did not change during conversion. CONCLUSIONS AND CLINICAL IMPORTANCE Vagally associated AF in GS dogs is terminated with lidocaine. Lidocaine is likely an effective treatment in clinical dogs with vagally associated AF.
Fuzzy PID for Quadrotor Space Fixed-Point Position Control

Quadrotor is widely used in the military or civil, which thanks to its high maneuverability, low maintenance cost and easy research. In real life, space fixed-point position control is necessary and essential because of the outdoor GPS or indoor visual positioning. All kinds of research and development are based on the great control performance. However, under actuated, strong coupling and nonlinear properties makes us cannot get accurate models of quadrotor. How to get a smooth and efficient performance for the quadrotor space fixed-point position control in a variety of conditions attracts a lot of researchers. According to the features of quadrotor, this paper we put forward fuzzy PID controller for space fixed-point position control. This fuzzy PID controller is widely used in cases where mathematical models of system cannot be get in accurate modeling with nonlinear. Based on fuzzy-set theory, fuzzy language variables and fuzzy logic-based intelligent computer control, this make the fuzzy PID have the ability of self-tuning according to the current environment. By comparing the traditional PID and fuzzy PID for quadrotor space fixed-point position control with Matlab simulation and actual flight test, fuzzy PID perform well than traditional PID.
Menstrual phase effects on smoking relapse.

AIMS To examine if menstrual phase affects relapse in women attempting to quit smoking. DESIGN An intent-to-treat randomized smoking cessation trial where women were assigned to quit smoking in either the follicular (F) or luteal (L) menstrual phase and were followed for up to 26 weeks. They were assessed for relapse by days to relapse and relapse phase to determine if those who begin a quit attempt during the F phase were more successful than those who begin during the L phase. SETTING Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota. PARTICIPANTS A total of 202 women. MEASUREMENTS Latency to relapse from continuous and prolonged abstinence, point prevalence, phase of relapse, first slip within the first 3 and 5 days post-quit date, subject completion rates and symptomatology (i.e. withdrawal and craving). FINDINGS The mean days to relapse from continuous abstinence and relapse from prolonged abstinence for the F group were 13.9 and 20.6 days, respectively, and 21.5 and 39.2 days, respectively, for the L group. Using point prevalence analysis at 14 days, 84% of the F group had relapsed compared with 65% of the L group [chi(2)=10.024, P=0.002; odds ratio (OR) = 2.871, 95% confidence interval (CI), 1.474-5.590]. At 30 days, 86% of the F group relapsed, compared with 66% of the L group (chi(2)=11.076, P=0.001; OR=3.178, 95% CI, 1.594-6.334). CONCLUSION Women attempting to quit smoking in the F phase had less favorable outcomes than those attempting to quit in the L phase. This could relate to ovarian hormones, which may play a role in smoking cessation for women.
Circadian Intraocular Pressure Fluctuation and Disease Progression in Primary Angle Closure Glaucoma.

PURPOSE To document the continuous circadian intraocular pressure (IOP) fluctuation using a contact lens sensor during normal daily activities, and to study the relationship between IOP fluctuation and disease progression in primary angle closure glaucoma (PACG) eyes. METHODS Circadian IOP fluctuations were recorded by Sensimed Triggerfish sensors in 25 PACG eyes. The sensor output signals were smoothed using B-spline smoothing transform and described by functional data analysis. Glaucoma progression was documented with serial changes in mean deviation (MD) and visual field index (VFI) in Humphrey automated perimetry and retinal nerve fiber layer (RNFL) thickness. The signals were compared between the progressive and stable groups by permutation tests on functional t-statistic. RESULTS Statistically significant differences were found from 2200 to 2300 and from 0700 to 0800 in gradients of the IOP fluctuation curve, as well as from 2300 to 2400 and 0800 to 0900 in curvatures of the IOP fluctuation curves, between the progressive MD and stable MD groups (P < 0.05). Significant gradient differences were also found from 1500 to 1600 and 0600 to 0800 between the progressive VFI and stable VFI groups, and from 2400 to 0100 and 0200 to 0300 between the progressive RNFL and stable RNFL groups (P < 0.05). CONCLUSIONS Significant differences in circadian IOP fluctuation between progressive and stable PACG eyes were identified. Large IOP fluctuations may be associated with disease progression in PACG eyes.
Nationwide German Multicenter Study on Prevalence of Antibiotic Resistance in Staphylococcal Bloodstream Isolates and Comparative In Vitro Activities of Quinupristin-Dalfopristin

ABSTRACT Antibiotic-resistant gram-positive bacteria have become an increasing problem in the last two decades. In order to evaluate the prevalence of antibiotic resistance in staphylococcal bloodstream isolates in Germany, 2,042 staphylococci collected in 21 tertiary-care hospitals were investigated during a 3-year period (March 1996 to March 1999). Altogether, 1,448 S. aureus isolates and 594 coagulase-negative staphylococci (CoNS) that comprised 13 different species were included. Furthermore, the antistaphylococcal activities of quinupristin-dalfopristin were compared with those of eight other compounds by the broth microdilution method. The rates of oxacillin resistance in Staphylococcus aureus, S. epidermidis, S. haemolyticus, and other CoNS were 13.5, 69, 90, and 34%, respectively. In oxacillin-resistant strains high rates of resistance (up to 100%) to erythromycin, clindamycin, ciprofloxacin, and gentamicin were also observed. However, no strain appeared to be resistant to vancomycin or quinupristin-dalfopristin. The streptogramin combination exhibited excellent in vitro activity against all staphylococcal species tested, regardless of the patterns of resistance to other drug classes. In terms of MICs at which 90% of the isolates are inhibited, quinupristin-dalfopristin was 2 times more active against S. aureus isolates, 4 to 16 times more active against S. haemolyticus, and 8 to 32 times more active against S. epidermidis than vancomycin or teicoplanin.
Collision avoidance system with situational awareness capabilities for autonomous MAV indoor flights

Micro Aerial Vehicles (MAVs) lend themselves to perform supporting reconnaissance flights and provide rescue forces with important information beyond their own field of vision. In this paper, we present an auto-adaptive collision avoidance system to aid indoor reconnaissance missions of autonomous MAVs by means of situational awareness. Efficient multi-sensor indoor classification and landmark detection on the fly serve an Artificial Potential Field (APF) based motion control. In applying supplemental potentials tailored to the specific needs of the detected surrounding situations, control factor calculation remains merely reactive. Yet, the resulting virtual force field will imply simultaneous obstacle avoidance and intelligent flight control. The system is depending only on data from camera, 2D laser rangefinder and inertial measurement unit. Neither a data link to the ground station nor any training data is required to independently explore accessible interior space in unknown environment. Finally, availability for use is validated by both simulated and real flight data.
Effects of visual deprivation upon the geniculocortical W‐cell pathway in the cat: Area 19 and its afferent input

We studied the receptive field properties of 206 single units in area 19 of normal cats and 228 single units in area 19 of cats deprived of vision for 9‐14 months by monocular lid suture. The ocular dominance of a sample of cells in area 17 of normal cats was studied for comparison. In some of these monocularly deprived animals, we also studied the sizes of relay cells in the parvocellular C laminae of the dorsal lateral geniculate nucleus labeled by electrophoretic injections of horseradish peroxidase into area 19.