Miracle-dz/UniFAR-FTUs huggingface dataset:
Are articulatory commands automatically and involuntarily activated during speech perception?

A recent PNAS article by Yuen et al. (1) presented evidence for articulation-specific effects of auditory speech on subsequent production of spoken syllables (Expt 1). This was interpreted as evidence that motor routines are “automatically” and “involuntarily” activated by heard speech, and the authors concluded their paradigm provides “a behavioral diagnostic for the activation of articulatory information in speech perception. ” Electropalatography is an appealing approach to investigating the nature of motor involvement in speech perception. The authors demonstrated that an incongruent alveolar /t/ sound led to a greater proportion of alveolar tongue contact in the initial phase of subsequent production of /s/ and /k/ sounds, relative to a congruent condition. However, the claim that hearing speech evokes automatic motor activation is undermined by the inclusion of an overt phoneme monitoring task on the auditory speech. In Experiment 1, participants heard a distractor syllable, then received a written cue to produce a rhyming target aloud, after which they were visually prompted to indicate whether or not a specific phoneme had occurred in the original distractor. Phoneme monitoring requires segmentation of heard speech into its constituent elements, and it has long been argued that such tasks engage neural systems beyond those associated with normal speech comprehension (2, 3). For example, illiterate individuals can understand speech but cannot perform simple phoneme segmentation (4). Consistent with this perspective, a recent study showed that repetitive transcranial magnetic stimulation (TMS) applied to premotor cortex has a detrimental effect on performance of a task requiring phoneme segmentation, but has no effect on tasks that relied on simpler acoustic processing (e.g., identification of isolated phonemes) (5).
Basing Airtankers for Forest Fire Control in Ontario

The Ontario Ministry of Natural Resources (OMNR) operates a fleet of nine CL-215 airtankers for forest fire control. The aircraft are based at a small number of airports that serve as home bases, from which they are deployed to a larger set of airports that serve as initial attack bases for fire fighting operations each day. We helped regional fire managers derive subjective airtanker deployment rules that specified how many airtankers were to be deployed at each initial attack base each day. We then developed a mathematical programming model that was used to help identify a home-basing strategy that would minimize the average annual cost of satisfying daily airtanker deployment demands. Our analysis provided OMNR decision makers with valuable insight into airtanker management and was used to help decide where to base the OMNR airtankers for the 1993 and subsequent fire seasons.
Ribosomal Pausing at a Frameshifter RNA Pseudoknot Is Sensitive to Reading Phase but Shows Little Correlation with Frameshift Efficiency

ABSTRACT Here we investigated ribosomal pausing at sites of programmed −1 ribosomal frameshifting, using translational elongation and ribosome heelprint assays. The site of pausing at the frameshift signal of infectious bronchitis virus (IBV) was determined and was consistent with an RNA pseudoknot-induced pause that placed the ribosomal P- and A-sites over the slippery sequence. Similarly, pausing at the simian retrovirus 1 gag/pol signal, which contains a different kind of frameshifter pseudoknot, also placed the ribosome over the slippery sequence, supporting a role for pausing in frameshifting. However, a simple correlation between pausing and frameshifting was lacking. Firstly, a stem-loop structure closely related to the IBV pseudoknot, although unable to stimulate efficient frameshifting, paused ribosomes to a similar extent and at the same place on the mRNA as a parental pseudoknot. Secondly, an identical pausing pattern was induced by two pseudoknots differing only by a single loop 2 nucleotide yet with different functionalities in frameshifting. The final observation arose from an assessment of the impact of reading phase on pausing. Given that ribosomes advance in triplet fashion, we tested whether the reading frame in which ribosomes encounter an RNA structure (the reading phase) would influence pausing. We found that the reading phase did influence pausing but unexpectedly, the mRNA with the pseudoknot in the phase which gave the least pausing was found to promote frameshifting more efficiently than the other variants. Overall, these experiments support the view that pausing alone is insufficient to mediate frameshifting and additional events are required. The phase dependence of pausing may be indicative of an activity in the ribosome that requires an optimal contact with mRNA secondary structures for efficient unwinding.
Adsorption and penetration of enveloped and naked vaccinia virus particles

The adsorption and penetration of intracellular naked vaccinia virus (INV) and extracellular enveloped vaccinia virus (EEV) were examined. The adsorption kinetics of INV and EEV were similar, but INV adsorption was found to be more sensitive to the adsorption environment than EEV. The PFU-to-particle ratio for the two virus particles indicated that EEV was approximately two times as infectious as INV. Kinetic studies at 37 degree C showed that EEV penetrated cells more rapidly than INV. Penetration of EEV was unaffected by incubation in phsophate-buffered saline, but was somewhat reduced by incubation at 22 degree C. In contrast, INV penetration was effectively eliminated by incubation in phosphate-buffered saline or by incubation at 22 degree C. In addition, INV but not EEV pentration was sensitive to treatment with sodium fluoride and cytochalasin. B. These results are discussed with regard to the mechanism of INV and EEV penetration.
The Therapeutic Potential of Monocyte/Macrophage Manipulation in the Treatment of Chemotherapy-Induced Painful Neuropathy

In cancer treatments a dose-limiting side-effect of chemotherapeutic agents is the development of neuropathic pain, which is poorly managed by clinically available drugs at present. Chemotherapy-induced painful neuropathy (CIPN) is a major cause of premature cessation of treatment and so a greater understanding of the underlying mechanisms and the development of novel, more effective therapies, is greatly needed. In some cases, only a weak correlation between chemotherapy-induced pain and neuronal damage is observed both clinically and preclinically. As such, a critical role for non-neuronal cells, such as immune cells, and their communication with neurons in CIPN has recently been appreciated. In this mini-review, we will discuss preclinical evidence for the role of monocytes/macrophages in the periphery in CIPN, with a focus on that which is associated with the chemotherapeutic agents vincristine and paclitaxel. In addition we will discuss the potential mechanisms that regulate monocyte/macrophage–neuron crosstalk in this context. Informed by preclinical data, we will also consider the value of monocytes/macrophages as therapeutic targets for the treatment of CIPN clinically. Approaches that manipulate the signaling pathways discussed in this review show both promise and potential pitfalls. Nonetheless, they are emerging as innovative therapeutic targets with CX3CL1/R1-regulation of monocyte/macrophage–neuron communication currently emerging as a promising front-runner.
A secure cloud storage system for small and medium enterprises

In Africa, as in other developing countries, small and medium sized enterprises (SMEs) are progressively becoming the target of cyber-attacks. This is because such SMEs often store valuable and sensitive data of customers, clients etc, and because often they do not have the security expertise and the financial resources to protect the confidentiality and integrity of their data. Such companies need a cost-effective, user-friendly and easy to maintain solution for securing their data and information in a transparent way. This paper introduces such a solution called SFSData, which secures data and information stored locally or through some cloud facility.
Antenna-array topologies for mm-wave beamforming transmitter with quadrature spatial combining

In this paper, we present several antenna-array topologies for quadrature spatial combining: In-phase and Quadrature signals are not anymore combined at the circuit level but rather spatially in free space. To demonstrate the feasibility of this concept, an organic module with two 4×1 antenna-arrays is fabricated and measured in V-band. Reflection coefficient and realized gain measurements are very promising.
Efficient Competition Through Cheap Talk: The Case of Competing Auctions

We consider a large market where auctioneers with private reservation values compete for bidders by announcing cheap‐talk messages. If auctioneers run efficient first‐price auctions, then there always exists an equilibrium in which each auctioneer truthfully reveals her type. The equilibrium is constrained efficient, assigning more bidders to auctioneers with larger gains from trade. The choice of the trading mechanism is crucial for the result. Most notably, the use of second‐price auctions (equivalently, ex post bidding) leads to the nonexistence of any informative equilibrium. We examine the robustness of our finding in various dimensions, including finite markets and equilibrium selection.
Toxoplasma gondii Virulence Factor ROP18 Inhibits the Host NF-κB Pathway by Promoting p65 Degradation*

Background: ROP18 is a Toxoplasma secreted Ser/Thr protein kinase important for acute virulence. Results: ROP18 phosphorylates host p65 at Ser-468 and target this protein to the ubiquitin-dependent degradation. Conclusion: ROP18 inhibits the host NF-κB pathway by promoting p65 degradation. Significance: These findings reveal a novel molecular mechanism by which type I strain manipulates the host immune system to facilitate infection. The obligate intracellular parasite Toxoplasma gondii secretes effector molecules into the host cell to modulate host immunity. Previous studies have shown that T. gondii could interfere with host NF-κB signaling to promote their survival, but the effectors of type I strains remain unclear. The polymorphic rhoptry protein ROP18 is a key serine/threonine kinase that phosphorylates host proteins to modulate acute virulence. Our data demonstrated that the N-terminal portion of ROP18 is associated with the dimerization domain of p65. ROP18 phosphorylates p65 at Ser-468 and targets this protein to the ubiquitin-dependent degradation pathway. The kinase activity of ROP18 is required for p65 degradation and suppresses NF-κB activation. Consistently, compared with wild-type ROP18 strain, ROP18 kinase-deficient type I parasites displayed a severe inability to inhibit NF-κB, culminating in the enhanced production of IL-6, IL-12, and TNF-α in infected macrophages. In addition, studies have shown that transgenic parasites carrying kinase-deficient ROP18 induce M1-biased activation. These results demonstrate for the first time that the virulence factor ROP18 in T. gondii type I strains is responsible for inhibiting the host NF-κB pathway and for suppressing proinflammatory cytokine expression, thus providing a survival advantage to the infectious agent.
Determining the onset of hydrodynamic erosion in turbulent flow

We revisit the longstanding question of the onset of sediment transport driven by a turbulent fluid flow via laboratory measurements. We use particle tracking velocimetry to quantify the fluid flow as well as the motion of individual grains. As we increase the flow speed above the transition to sediment transport, we observe that an increasing fraction of grains are transported downstream, although the average downstream velocity of the transported grains remains roughly constant. However, we find that the fraction of mobilized grains does not vanish sharply at a critical flow rate. Additionally, the distribution of the fluctuating velocities of non-transported grains becomes broader with heavier tails, meaning that unambiguously separating mobile and static grains is not possible. As an alternative approach, we quantify the statistics of grain velocities by using a mixture model consisting of two forms for the grain velocities: a decaying-exponential tail, which represents grains transported downstream, and a peaked distribution centered at zero velocity, which represents grains that fluctuate due to the turbulent flow but remain in place. Our results suggest that more sophisticated statistical measures may be required to quantify grain motion near the onset of sediment transport, particularly in the presence of turbulence.
Comparative spatial genetics and epigenetics of plant populations: heuristic value and a proof of concept

Despite the recent upsurge of interest on natural epigenetic variation of nonmodel organisms, factors conditioning the spatial structure of epigenetic diversity in wild plant populations remain virtually unexplored. We propose that information on processes shaping natural epigenetic variation can be gained using the spatial structure of genetic diversity as null model. Departures of epigenetic isolation‐by‐distance (IBD) patterns from genetic IBD patterns for the same sample, particularly differences in slope of similarity‐distance regressions, will reflect the action of factors that operate specifically on epigenetic variation, including imperfect transgenerational inheritance and responsiveness to environmental factors of epigenetic marks. As a proof of concept, we provide a comparative analysis of spatial genetic and epigenetic structure of 200 mapped individuals of the perennial herb Helleborus foetidus. Plants were fingerprinted using nuclear microsatellites, amplified fragment length polymorphisms (AFLP) and methylation‐sensitive AFLP markers. Expectations from individual‐level IBD patterns were tested by means of kinship‐distance regressions. Both genetic and epigenetic similarity between H. foetidus individuals conformed to theoretical expectations under individual‐level IBD models. Irrespective of marker type, there were significant negative linear relationships between the kinship coefficient for plant pairs and their spatial separation. Regression slopes were significantly steeper for epigenetic markers. Epigenetic similarity between individuals was much greater than genetic similarity at shortest distances, such epigenetic ‘kinship excess’ tending to decrease as plant separation increased. Results suggest that moderate‐to‐high heritability and responsiveness to local environments are major drivers of epigenetic spatial structure in H. foetidus, and illustrate the heuristic value of comparing genetic and epigenetic spatial structure for formulating and testing hypotheses on forces shaping epigenetic diversity in wild plant populations.
Study of Functional Relevant Conformational Mobility of β-2 Adrenoreceptor by Means of Molecular Dynamics Simulation

— The study reports about the influence of binding of orthosteric ligands as well as point mutations on the conformational dynamics of β-2-adrenoreceptor. Using molecular dynamics simulation we found that there was a little fraction of active states of the receptor in its apo (ligand free) ensemble corresponded to its constitutive activity. Analysis of MD trajectories indicated that such spontaneous activation of the receptor is accompanied by the motion in intracellular part of its alpha-helices. Thus receptor’s constitutive activity directly results from its conformational dynamics. On the other hand the binding of a full agonist resulted in a significant shift of the initial equilibrium towards its active state. Finally, the binding of the inverse agonist stabilized the receptor in its inactive state. It is likely that the binding of inverse agonists might be a universal way of constitutive activity inhibition in vivo . Our results indicate that ligand binding redistribute pre-existing conformational degrees of freedom (in accordance to the Monod-Wyman-Changeux-Model) of the receptor rather than cause induced fit in it. Therefore, the ensemble of biologically relevant receptor conformations is encoded in its spatial structure, and individual conformations from that ensemble might be used by the cell in conformity with the physiological behavior.
Design and implementation of a hybrid maximum power point tracker in solar power system

This paper provides a hybrid maximum power point tracker (MPPT) with both perturbation and observation method and open circuit voltage method in solar power system. The open circuit voltage method is initially used to retrieve the open circuit voltage corresponding to maximum power point. The perturbation and observation method starts up instead while the input voltage of the power converter reaches the calculated maximum voltage. Furthermore, a variable range is defined by the calculated maximum voltages, and the perturbation and observation method is still used for MPPT if the subsequently sensed voltage value falls within this determined range. On the other hand, the open circuit voltage method is reused to function as MPPT again if the sensed voltage value does not fall within the range. That is, the proposed method will omit small power perturbation to decrease the tracking time and oscillation phenomenon at maximum power point caused by conventional perturbation and observation method, and therefore the loss reduction. The duty cycle is set the same as the previous duty cycle while the observed power reaches the predetermined range. HT46F49E MCU is used to implement the proposed MPPT method and a boost converter is utilized to act the power topology. The experiments confirm with the predetermined results.
The Foundations of Limited Authoritarian Government: Institutions and Power-Sharing in Dictatorships

Why do some dictatorships establish institutions that may constrain their leaders? We argue that institutions promote the survival of dictatorships by facilitating authoritarian power-sharing. Specifically, institutions such as parties, legislatures, and advisory councils alleviate commitment and monitoring problems between the dictator and his allies caused by the secrecy in authoritarian governance. However, because authoritarian power-sharing succeeds only when it is backed by a credible threat of a rebellion by the dictator’s allies, institutions will be ineffective or break down when an imbalance of power within the ruling coalition undermines this threat’s credibility. Our arguments clarify the complex interaction between collective action, commitment, and monitoring problems in authoritarian governance. We use both historical and large-N data to assess new empirical predictions about the relationship between political institutions, leader survival, and the concentration of power in dictatorships.
Dynamic adaptive shadow maps on graphics hardware

Author(s): Lefohn, Aaron; Sengupta, Shubhabrata; Kniss, Joe M. ; Strzodka, Robert; Owens, John D. | Abstract: We present a novel implementation of adaptive shadow maps (ASMs) that performs all shadow lookups and scene analysis on the GPU, enabling interactive rendering with ASMs while moving both the light and camera. Adaptive shadow maps offer a rigorous solution to projective and perspective shadow map aliasing while maintaining the simplicity of a purely image-based technique. The complexity of the ASM data structure, however, has prevented full GPU-based implementations until now. Our approach uses an entirely GPU-based data structure and a blend of graphics and GPU stream programming. We support shadow map effective resolutions up to 131,072 x 131,072 and, unlike previous implementations, provide smooth transitions between resolution levels by trilinearly filtering (mipmapping) the shadow lookups.
SymSum: Symmetric-Sum Distinguishers Against Round Reduced SHA3

In this work we show the existence of special sets of inputs for which the sum of the images under SHA3 exhibits a symmetric property. We develop an analytical framework which accounts for the existence of these sets. The framework constitutes identification of a generic property of iterated SPN based functions pertaining to the round-constant addition and combining it with the notion of m −fold vectorial derivatives for differentiation over specially selected subspaces. Based on this we propose a new distinguisher called SymSum for the SHA3 family which penetrates up to 9 rounds and outperforms the ZeroSum distinguisher by a factor of four. Interestingly, the current work is the first analysis of SHA3/Keccak that relies on round-constants but is independent of their Hamming-weights.
Mutational screening of the coding region of growth differentiation factor 9 gene in Indian women with ovarian failure

Objective:To establish the risk associated with mutations in the coding region of GDF9 gene in Indian women with ovarian failure. Design:This case-control study was designed for mutational analysis of the GDF9 coding region in a cohort of women with premature ovarian failure (n = 127), primary amenorrhea (n = 58), and secondary amenorrhea (n = 10) compared with controls (n = 220). Results:This case-control study revealed eight mutations in the GDF9 gene, including five novel mutations: c.1-8C>T, c.199A>C (p.Lys67Glu), c. 205C>T, c.646G>A (p.Val216Mat), and c.1353C>T, and three documented mutations: c.398-39C>G, c.447C>T, and c.546G>A. Missense mutation c.199A>C was present in 4 of 127 premature ovarian failure (POF) cases and 1 of 10 secondary amenorrhea cases. The c.646G>A mutation was present in two POF cases. Both missense mutations were absent in controls. Genotype distribution of c.447C>T was significantly different in POF cases than controls (χ2 = 5.93, P = 0.05). We chose two frequent single-nucleotide polymorphisms (c.398-39C>G, c.447C>T) for haplotyping and found that the C-T haplotype was significantly higher in patients (P = 0.03), whereas the C-C haplotype was representative of the control group. Conclusions:We report two rare missense mutations, c.199A>C and c.646G>A, which are associated with ovarian failure. The presence of the c.447>T mutation might indicate a higher risk for POF. Haplotype C-T was significantly associated with ovarian failure, whereas the C-C haplotype was representative of the control group.
Role of smoking in low birth weight.

OBJECTIVE To assess the role of smoking on low birth weight (LBW). STUDY DESIGN From Massachusetts for 1998, 79,904 birth certificates were reviewed. Birth weight, gestational age, plurality and maternal race were analyzed in relation to the mother's smoking status during the pregnancy. The etiologic fraction (EF) was calculated for smoking and LBW for the group as a whole as well as for various subgroups. RESULTS A total of 11.7% of women acknowledged smoking during pregnancy. The overall LBW rate was 6.83%. The relative risk (RR) of LBW among smokers was 1.58. For all births the EF for smoking was 6.4% (95% CI: 5.4-7.3). For singleton pregnancies it was 10.9% (95% CI: 9.6-12.1) (14% for singleton whites and 7.2 for singleton blacks). At term, the EF of smoking on LBW was 13.4% (95% CI: 11.5-15.3), with an EF of 16.7% (95% CI: 14.5-18.7) for term singletons (21.4% among whites and 14.6% among blacks). Among very LBW infants, smoking accounted for 1.7% (95% CI:--0.5-3.8) of the outcome (5.8% among singletons). When stratifying for the effect of smoking, the rate of LBW was 6.38% among nonsmokers, 9.5% (RR 1.48, 1.38-1.61) among light smokers, 11.67% (RR 1.82, 1.63-2.05) among moderate smokers and 11.72% (RR 1.84, 1.33-2.54) among heavy smokers. Sixty percent of the overall population effect of smoking on LBW was in the category of light smokers. CONCLUSION The amount of LBW attributable to smoking was 6.4% in this sample. Among those who smoked, LBW was 58% more likely than among nonsmokers, and 60% of the overall population effect of smoking on LBW was noted among light smokers.