Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulations of soleus H‐reflex excitability during gait initiation: Central versus peripheral influences

Soleus and tibialis anterior electromyogram (EMG) and soleus H‐reflexes were recorded from the stance limb of an individual who suffered a traumatic peroneal nerve injury and of four nonimpaired individuals during gait initiation. The control subjects also initiated walking after swaying forward (sway‐gait initiation), which eliminated the initial tibialis anterior activation. During the initial period of gait initiation, H‐reflexes were depressed to 43% of standing values during normal‐gait initiation and 86% during sway‐gait initiation in the nonimpaired subjects. H‐reflexes of the nerve‐injured subject were depressed to 37%, even though no tibialis anterior EMG was observed. The findings support the view that reciprocal inhibition of the soleus during a task, which normally involves tibialis anterior activation, is due to a centrally mediated process. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 1371–1379, 2001
The effect of body weight support treadmill training on paretic leg contribution in hemiparetic walking in persons with chronic stroke

Body weight support treadmill training (BWSTT) has proven to increase the walking speed of patients with stroke. However, there is minimal research on the effects of BWSTT on the function of the paretic and non-paretic limbs, relative to walking speed. The purpose of this study was to assess the effect of BWSTT on paretic limb function using the outcome measures of overground walking velocity, paretic leg propulsion, and mechanical work produced by the hip, knee, and ankle of the paretic limb. Thirteen participants with chronic stroke, ranging in age from 40 to 80 years, completed 24 sessions of BWSTT over eight weeks. Overground walking velocity and bilateral kinematics and kinetics were collected prior to and following completion of the BWSTT intervention. All participants exhibited statistically significant increases in overground walking velocity post BWSTT. Neither the propulsive impulse of the paretic limb, relative to total propulsive impulse, nor the relative contribution of the paretic hip, knee, and ankle to total positive work significantly changed post BWSTT. The results suggest that paretic limb function remains unchanged following BWSTT, despite improvements in overground walking velocity.
A Survey On Intrusion Detection System In Wireless Sensor Networks

Wireless Sensor Network (WSN) refers to a group of specialized transducers with a communications infrastructure for monitor and record the physical conditions of the environment and organizing the collected data at a central location. Security of Wireless Sensor Network is the most important Issue with the fast development of WSN. There are different types of attacks that can affect the network. Intrusion Detection System can be used to effective and efficient defective of attacks in WSN. In this survey paper, discuss about several existing approaches to describe how they have identified the attacks and implemented their intrusion detection system.
Solid waste sites and the black Houston community.

This paper presents data on the siting of solid waste facilities in one of the nation's fastest growing cities, Houston, Texas. The findings reveal that solid waste sites were not randomly scattered over the Houston landscape but were likely to be found in predominantly black neighborhoods and near black schools. Institutionalized discrimination in the housing market, lack of zoning, and decisions by public officials over the past fifty years are major factors that have contributed to Houston's black neighborhoods becoming the “dumping ground” for the area's solid waste.
Design method of CRLH TL inspired phase shifters

A time-efficient method is described for designing metamaterial transmission lines (TL) with a required phase shift over a given frequency band with rigorous phase accuracy. This time-efficient method is proposed to make possible industrial application phase shiftersof Composite Right/Left-Handed (CRLH) TL phase shifter for phase compensation solution. A theoretical model is developed by the use of the TL model and of its Bloch phase and impedance. The extraction method of the technological parameters from this model is also explained. To illustrate this method, two CRLH TLs are presented and compared to a conventional phase shifter transmission line.
Fluctuating asymmetry and the human brain

Adaptive development requires the organism to resist genetic and environmental stresses that disrupt the genetic plan for growth, a buffering capacity termed developmental stability. Developmental instability is revealed by fluctuating asymmetry (FA), which has been demonstrated in many species to reflect phenotypic and genetic quality. We report (1) that a measure of developmental instability based on body FA predicts deviation from typical brain asymmetry, (2) that a combined measure of atypical brain asymmetry and body FA correlated negatively with the area of the corpus callosum, especially the portion connecting the left and right planum temporale, and (3) that this combined measure also predicted atypical asymmetry of the size of the somatosensory representation of the two hands, as determined from magnetic source imaging.
ERP and fMRI correlates of endogenous and exogenous focusing of visual‐spatial attention

The aim of this study was to investigate the neural correlates of the functional distinction underlying attentional mechanisms of endogenous‐sustained and exogenous‐transient spatial selection. We recorded event related potentials (ERPs) and used functional magnetic resonance imaging (fMRI) in separate experiments while subjects performed a simple reaction time (RT) to the same visual stimulus displayed to one of several field locations. Endogenous‐sustained or exogenous‐transient focusing of attention onto target location were obtained by presenting the stimulus in blocks of same‐point vs. randomised‐point trials, respectively. Same‐point stimuli yielded overall faster RT than randomised stimuli, indicating a facilitating effect of endogenous‐sustained spatial attention on the perceptual processing of the impending stimulus. Moreover, same‐point vs. randomised presentations revealed significant increases in the fMRI signal in the bilateral lingual and fusiform gyri as well as in the right calcarine sulcus, in conjunction with a larger amplitude of the posterior P1 component of ERPs, but no modulation of the amplitude of the N1 component. Rather, a larger amplitude of N1 was found in the reverse contrast, randomised minus same‐point trials, which revealed increases in the fMRI signal along the posterior left superior frontal sulcus and bilaterally in the superior precuneus. These findings indicate that N1 indexes exogenous orienting of attention and is likely to represent the activity of frontal and parietal components of the attention network involved in eliciting attention changes. In contrast, the effects of those changes, resulting in a modulation of activation in visual occipital areas, are indexed by P1.
Treatment of Dystonia

Therapeutic strategies in the treatment of dystonia consist primarily of pharmacologic, surgical, and supportive approaches. Many recent advances have been made in the treatment of dystonia with newer medications, availability of different botulinum toxins, and surgical procedures. However, these treatment modalities all have limiting factors and varying levels of efficacy. Studies range from case reports and open-label trials to double-blind placebo-controlled trials. More research and larger studies are needed to explore these newer medications and surgical techniques for both primary focal and generalized dystonia. Studies in functional outcome and quality of life further support the importance of discovering safe and effective means to treat dystonia. An algorithmic approach may be useful to guide the physician along the various treatment choices.
Pasteurella multocida and bovine respiratory disease

Abstract Pasteurella multocida is a pathogenic Gram-negative bacterium that has been classified into three subspecies, five capsular serogroups and 16 serotypes. P. multocida serogroup A isolates are bovine nasopharyngeal commensals, bovine pathogens and common isolates from bovine respiratory disease (BRD), both enzootic calf pneumonia of young dairy calves and shipping fever of weaned, stressed beef cattle. P. multocida A:3 is the most common serotype isolated from BRD, and these isolates have limited heterogeneity based on outer membrane protein (OMP) profiles and ribotyping. Development of P. multocida-induced pneumonia is associated with environmental and stress factors such as shipping, co-mingling, and overcrowding as well as concurrent or predisposing viral or bacterial infections. Lung lesions consist of an acute to subacute bronchopneumonia that may or may not have an associated pleuritis. Numerous virulence or potential virulence factors have been described for bovine respiratory isolates including adherence and colonization factors, iron-regulated and acquisition proteins, extracellular enzymes such as neuraminidase, lipopolysaccharide, polysaccharide capsule and a variety of OMPs. Immunity of cattle against respiratory pasteurellosis is poorly understood; however, high serum antibodies to OMPs appear to be important for enhancing resistance to the bacterium. Currently available P. multocida vaccines for use in cattle are predominately traditional bacterins and a live streptomycin-dependent mutant. The field efficacy of these vaccines is not well documented in the literature.
Diabetes Implementation of a Self-management Program in Resource Poor and Rural Community Clinics

Purpose: To evaluate the implementation of a brief diabetes self-management support intervention designed for resource-poor community clinics. Methods: The authors conducted a pilot study among patients with type 2 diabetes in 3 community clinics. The intervention consisted of research assistants introducing and reviewing a diabetes self-management guide, helping patients set an achievable behavioral action plan, and following up with 2 telephone sessions. The primary outcome was patients’ success setting and achieving behavioral goals. Results: All participants set an action plan (N = 247); most focused on physical activity or diet (97%). The initial session took an average of 15 minutes. At 2 to 4 weeks, 200 participants were contacted; 68% recalled their action plan; and 84% of these achieved it. At 6 to 9 weeks, approximately half of those who completed the first call were reached for the second call. Of those who remained in the intervention, 79% recalled their action plan, and 80% of these achieved it. At the end of the study, 62% of those initially enrolled reported behavior change. Most participants who did not complete the intervention could not be reached for telephone follow-up. Conclusions: Although only about a third of patients remained engaged through the 2 follow-up calls, most of those who did reported they had achieved their action plan. This pilot study provides insight into initiating brief diabetes self-management strategies in resource-poor community clinics. Although telephone follow-up was challenging, using the self-management guide and action plan framework, particularly during the initial clinic visit, helped focus patients on behavior change.
Identification of a cysteine-rich receptor for fibroblast growth factors

The fibroblast growth factor (FGF) family consists of seven members whose activities are thought to be mediated by multiple receptors. Here we describe the cDNA cloning, expression, and characterization of a cysteine-rich FGF receptor (CFR) that is distinct from previously identified FGF receptors. The deduced amino acid sequence for CFR suggests that it is an integral membrane protein containing a large extracellular domain comprising 16 cysteine-rich repeated units and an intracellular domain of 13 amino acids. No reported sequences exhibit significant homologies to either the repeated extracellular motif or to the entire CFR amino acid sequence. Several CFR transcripts are present in embryonic chick tissue, suggesting that CFR undergoes alternate mRNA splicing or that related genes are present. Chinese hamster ovary cells transfected with the CFR cDNA express a 150-kDa polypeptide that binds FGF-1, FGF-2, and FGF-4 but does not bind several non-FGF family members. The high degree of evolutionary conservation among vertebrate CFRs and its ability to bind three different FGFs with high affinity suggest that this unique receptor plays an important role in FGF biology.
Peyer's Patch-Deficient Mice Demonstrate That Mycobacterium avium subsp. paratuberculosis Translocates across the Mucosal Barrier via both M Cells and Enterocytes but Has Inefficient Dissemination

ABSTRACT Mycobacterium avium subsp. paratuberculosis, the agent of Johne's disease, infects ruminant hosts by translocation through the intestinal mucosa. A number of studies have suggested that M. avium subsp. paratuberculosis interacts with M cells in the Peyer's patches of the small intestine. The invasion of the intestinal mucosa by M. avium subsp. paratuberculosis and Mycobacterium avium subsp. hominissuis, a pathogen known to interact with intestinal cells, was compared. M. avium subsp. paratuberculosis was capable of invading the mucosa, but it was significantly less efficient at dissemination than M. avium subsp. hominissuis. B-cell knockout (KO) mice, which lack Peyer's patches, were used to demonstrate that M. avium subsp. paratuberculosis enters the intestinal mucosa through enterocytes in the absence of M cells. In addition, the results indicated that M. avium subsp. paratuberculosis had equal abilities to cross the mucosa in both Peyer's patch and non-Peyer's patch segments of normal mice. M. avium subsp. paratuberculosis was also shown to interact with epithelial cells by an α5β1 integrin-independent pathway. Upon translocation, dendritic cells ingest M. avium subsp. paratuberculosis, but this process does not lead to efficient dissemination of the infection. In summary, M. avium subsp. paratuberculosis interacts with the intestinal mucosa by crossing both Peyer's patches and non-Peyer's patch areas but does not translocate or disseminate efficiently.
A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)

2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304) is an orally available, long-acting nonprostanoid prostacyclin receptor (IP receptor) agonist prodrug. In a rat model of pulmonary hypertension induced by monocrotaline (MCT), NS-304 ameliorated vascular endothelial dysfunction, pulmonary arterial wall hypertrophy, and right ventricular hypertrophy, and it elevated right ventricular systolic pressure and improved survival. {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid (MRE-269), the active form of NS-304, is much more selective for the IP receptor than are the prostacyclin analogs beraprost and iloprost, which also have high affinity for the EP3 receptor. To investigate the effect of receptor selectivity on vasodilation of the pulmonary artery, we assessed the relaxant response to these IP agonists in rats. MRE-269 induced vasodilation equally in large pulmonary arteries (LPA) and small pulmonary arteries (SPA), whereas beraprost and iloprost induced less vasodilation in SPA than in LPA. An EP3 agonist, sulprostone, induced SPA and LPA vasoconstriction, and an EP3 antagonist attenuated the vasoconstriction. Beraprost showed EP3 agonism and induced LPA and SPA vasoconstriction, whereas the EP3 antagonist inhibited this vasoconstriction and enhanced beraprost- and iloprost-induced SPA vasodilation. These findings suggest that the EP3 agonism of beraprost and iloprost interfered with the SPA vasodilation resulting from their IP receptor agonism. Endothelium removal markedly attenuated the vasodilation induced by beraprost, but not that induced by MRE-269 or iloprost. Moreover, the vasodilation induced by beraprost and iloprost, but not that induced by MRE-269, was more strongly attenuated in LPA from MCT-treated rats than from normal rats. NS-304 is a promising alternative medication for pulmonary arterial hypertension with prospects for good patient compliance.
Reducing Hazardous Chemical Exposures in the Neonatal Intensive Care Unit: A New Role for Nurses

A wide range of toxic chemicals have been found in the umbilical cord blood of newborns, indicating the potential for health risks from chemical exposure that begin in utero. The neonatal intensive care unit (NICU) setting may also have potential chemical exposures that create health risks. Given the extreme vulnerability of this patient population, it is critical to minimize unnecessary hazardous chemicals. Neonatal intensive care unit nurses have an important role to play in making the NICU as safe as possible for their patients and themselves. This article will focus on the human health effects of several chemical exposures commonly found in the NICU for which nurses can help to eliminate or select safer alternatives: (1) diethylhexyl phthalates (a plasticizer commonly found in intravenous tubing/bags and other products); (2) bisphenol A (commonly found in the lining of baby formula cans); (3) personal care products used in the NICU; (4) cleaning, sterilants, and disinfectants; and (5) mercury. A tool for assessing environmental health risks will be presented and associated intervention options including purchasing policies; hospital-wide chemical policies; and development of institutional infrastructures, such as Green Teams, to address NICU and hospital-wide environmental health concerns. Nursing's evolving role in environmental health will be reviewed.
Quad Screen as a Predictor of Adverse Pregnancy Outcome

Objective: To estimate the effect of second-trimester levels of maternal serum alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), unconjugated estriol (uE3), and inhibin A (the quad screen) on obstetric complications by using a large, prospectively collected database (the FASTER database). Methods: The FASTER trial was a multicenter study that evaluated first- and second-trimester screening programs for aneuploidy in women with singleton pregnancies. As part of this trial, patients had a quad screen drawn at 15–18 6/7 weeks. We analyzed the data to identify associations between the quad screen markers and preterm birth, intrauterine growth restriction, preeclampsia, and fetal loss. Our analysis was performed by evaluating the performance characteristics of quad screen markers individually and in combination. Crude and adjusted effects were estimated by multivariable logistic regression analysis. Patients with fetal anomalies were excluded from the analysis. Results: We analyzed data from 33,145 pregnancies. We identified numerous associations between the markers and the adverse outcomes. There was a relatively low, but often significant, risk of having an adverse pregnancy complication if a patient had a single abnormal marker. However, the risk of having an adverse outcome increased significantly if a patient had 2 or more abnormal markers. The sensitivity and positive predictive values using combinations of markers is relatively low, although superior to using individual markers. Conclusion: These data suggest that components of the quad screen may prove useful in predicting adverse obstetric outcomes. We also showed that the total number and specific combinations of abnormal markers are most useful in predicting the risk of adverse perinatal outcome. Level of Evidence: II-2
Effects of somatosensory cortical stimulation on expression of c‐Fos in rat medullary dorsal horn in response to formalin‐induced noxious stimulation

We examined the effects of epidural electrical stimulation of primary (SI) and secondary (SII) somatosensory cortex on expression of c‐Fos protein in rat medullary dorsal horn neurons (Vc; trigeminal nucleus caudalis) in response to formalin‐induced noxious stimulation. Epidural electrical stimulation (single pulse, 0.2 msec duration at 10 Hz) was applied to the left facial region SI or SII at three different stimulus intensities, 0.1, 0.5, and 1.0 mA for 60 min 0 or 2 hr after bilateral injection of formalin into the lower lip. SII stimulation at 1.0 mA immediately after injection of formalin, significantly decreased the number of Fos‐positive cells in the right VcI/II by 32.4%. There was no significant change in the number of Fos‐positive cells in the VcIII/IV. SII stimulation at 0.5 and 1.0 mA 2 hr after injection of formalin, significantly decreased the number of Fos‐positive cells in the right VcI/II by 47.9% and 40.8%, but significantly increased the number of Fos‐positive cells in the right VcIII/IV by 178.8% and 324.3%, respectively. In contrast, SI stimulation had no effect on expression of c‐Fos in Vc. Possible direct corticotrigeminal projections were labeled anterogradely by injection of WGA‐HRP into the SI and SII. In the Vc, labeled terminals were distributed mostly in the contralateral medial half of VcIII/IV and medullary reticular nucleus dorsalis but rarely in VcI/II. These results suggest that activation of SII‐medullary fibers suppress nociceptive information from the oro‐facial regions. © 2002 Wiley‐Liss, Inc.
Real-time Traffic Classification Algorithm Based on Hybrid of Signature Statistical and Port to Identify Internet Applications

Internet traffic classification gained significant attention in the last few years. Most of the current classification methods were only valid for offline classification. The three common classification methods i.e. port, payload and statistics based have some limitations. This paper exploits the advantages of all the three methods by combining them to produce a new classification algorithm called SSPC (Signature Statistical Port Classifier). In the proposed algorithm, each of the three classifiers will individually classify the same traffic flow. Based on certain priority rules, SSPC makes classification decisions for each flow. The SSPC algorithm was used to classifying four types of Internet applications in two stages, initially offline and later online. The results of both cases show that SSPC is the higher accuracy when compared with other classifiers. In addition, as demonstrated in the real time online experiments done, SSPC algorithm uses a short time to classify traffic and thus it is suitable to be used for online classification.