Miracle-dz/UniFAR-FTUs huggingface dataset:
A Compact Espar Antenna with Planar Parasitic Elements on a Dielectric Cylinder

This paper presents a technique for designing a dielectric Electronically Steerable Parasitic Array Radiator (Espar) antenna to achieve miniaturization of the conventional Espar antenna. The antenna's size is reduced by immersing the central active element in a dielectric cylinder, mounting the surrounding planar parasitic elements at the circumference of the cylinder, and decreasing the radius of the ground skirt to that of the parasitic elements. An example of a polycarbonate (∈ r = 2.9 + j0.006) Espar antenna operating at 2.484 GHz is optimised by using a genetic algorithm in conjunction with an FEM-based cost function. The designed antenna generates a half-power beam width of 78° and a main lobe that elevates at an angle of only 5° from the horizontal plane. The designed antenna is also fabricated and measured. Good agreement between the measurement and simulation results is obtained. We reduce the size of the designed Espar antenna to 1/8 the size of its conventional counterpart while achieving a 12° improvement in half-power beam width.
Encoderless field-oriented control of a synchronous reluctance machine with position and inductance estimators

A rotor position estimator for a synchronous reluctance machine (SynRM) is presented. The rotor position is directly calculated based on stator current measurements and voltage commands. For position information, two machine parameters are required, stator resistance and average inductance. The average inductance is estimated online as it is operation-point dependent. The two estimators are linearly independent and can be combined. The performance is demonstrated with experimental results.
Constructing a Foundational Platform Driven by Japan’s K Supercomputer for Next‐Generation Drug Design

The cost of pharmaceutical R&D has risen enormously, both worldwide and in Japan. However, Japan faces a particularly difficult situation in that its population is aging rapidly, and the cost of pharmaceutical R&D affects not only the industry but the entire medical system as well. To attempt to reduce costs, the newly launched K supercomputer is available for big data drug discovery and structural simulation‐based drug discovery. We have implemented both primary (direct) and secondary (infrastructure, data processing) methods for the two types of drug discovery, custom tailored to maximally use the 88 128 compute nodes/CPUs of K, and evaluated the implementations. We present two types of results. In the first, we executed the virtual screening of nearly 19 billion compound‐protein interactions, and calculated the accuracy of predictions against publicly available experimental data. In the second investigation, we implemented a very computationally intensive binding free energy algorithm, and found that comparison of our binding free energies was considerably accurate when validated against another type of publicly available experimental data. The common feature of both result types is the scale at which computations were executed. The frameworks presented in this article provide prospectives and applications that, while tuned to the computing resources available in Japan, are equally applicable to any equivalent large‐scale infrastructure provided elsewhere.
Tangibles for Health Workshop

eHealth research employing technology and HCI to support wellbeing, recovery and maintenance of conditions, has seen significant progress in recent years. However, such research has primarily focused on mobile "apps" running on commercial smartphones. We believe that Tangible User Interfaces (TUIs) offer many physical and interaction qualities that would benefit the eHealth community. Yet, there is little research that combines the two. Tangibles for Health will bring together leading researchers in tangible user interaction and health to explore the potential of tangibles as applied to healthcare and wellbeing.
PaperBLAST: Text Mining Papers for Information about Homologs

With the recent explosion of genome sequencing data, there are now millions of uncharacterized proteins. If a scientist becomes interested in one of these proteins, it can be very difficult to find information as to its likely function. Often a protein whose sequence is similar, and which is likely to have a similar function, has been studied already, but this information is not available in any database. To help find articles about similar proteins, PaperBLAST searches the full text of scientific articles for protein identifiers or gene identifiers, and it links these articles to protein sequences. Then, given a protein of interest, it can quickly find similar proteins in its database by using standard software (BLAST), and it can show snippets of text from relevant papers. We hope that PaperBLAST will make it easier for biologists to predict proteins’ functions. ABSTRACT Large-scale genome sequencing has identified millions of protein-coding genes whose function is unknown. Many of these proteins are similar to characterized proteins from other organisms, but much of this information is missing from annotation databases and is hidden in the scientific literature. To make this information accessible, PaperBLAST uses EuropePMC to search the full text of scientific articles for references to genes. PaperBLAST also takes advantage of curated resources (Swiss-Prot, GeneRIF, and EcoCyc) that link protein sequences to scientific articles. PaperBLAST’s database includes over 700,000 scientific articles that mention over 400,000 different proteins. Given a protein of interest, PaperBLAST quickly finds similar proteins that are discussed in the literature and presents snippets of text from relevant articles or from the curators. PaperBLAST is available at http://papers.genomics. lbl.gov/ . IMPORTANCE With the recent explosion of genome sequencing data, there are now millions of uncharacterized proteins. If a scientist becomes interested in one of these proteins, it can be very difficult to find information as to its likely function. Often a protein whose sequence is similar, and which is likely to have a similar function, has been studied already, but this information is not available in any database. To help find articles about similar proteins, PaperBLAST searches the full text of scientific articles for protein identifiers or gene identifiers, and it links these articles to protein sequences. Then, given a protein of interest, it can quickly find similar proteins in its database by using standard software (BLAST), and it can show snippets of text from relevant papers. We hope that PaperBLAST will make it easier for biologists to predict proteins’ functions.
Indirect MPI-based detection of superparamagnetic nanoparticles transported by computer-controlled magneto-aerotactic bacteria

MC-1 strain magneto-aerotactic bacteria recently used in cancer therapy and labeled with superparamagnetic nanoparticles are localized by magnetic particle imaging (MPI) spectrometry. A 8.5 mT drive field oscillating at 150 kHz is generated in a solenoid coil and placed near two receiving coils connected in series in a gradiometric configuration. The magnetic behavior of superparamagnetic particles attached to the MC-1 bacteria using MC-1 antibodies allowed the indirect detection of the MC-1 bacteria. It is moreover validated that the drive field does not break the covalent bond between the MC-1 antibodies coating the superparamagnetic particles and the MC-1 bacteria. The results presented here demonstrate the usability of a MPI device to provide a real-time evaluation of the evolution of cancer treatment using MC-1 bacteria as delivery vectors.
A Basic-HLH Transcription Factor, HLH54F, Is Highly Expressed in the Prothoracic Gland in the Silkworm Bombyx mori and the Fruit Fly Drosophila melanogaster

We describe our findings on HLH54F, a basic helix-loop-helix transcription factor gene that was highly expressed in the prothoracic gland, an organ producing the insect steroid ecdysone. HLH54F was uncovered by the use of an expressed sequence tag database of the silkworm Bombyx mori. It was also highly expressed in the prothoracic gland of the fruit fly Drosophila melanogaster.
Impedance matching considerations for passive UHF RFID tags

This paper is concentrated on analyzing the performance of passive ultra-high frequency (UHF) radio frequency identification (RFID) tags in which different impedance matching approaches have been used. Analysis and discussion is based on modeling results and measurements of the tags in active state. In the analysis, we will concentrate on comparing the performance of a dipole-type tag antenna with T-match, two-wire and three-wire folded dipole tag antennas and a microstrip patch-type tag antenna.
Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity

ABSTRACT Enviroxime is an antienterovirus compound that targets viral protein 3A and/or 3AB and suppresses a step in enterovirus replication by unknown mechanism. To date, four antienterovirus compounds, i.e., GW5074, Flt3 inhibitor II, TTP-8307, and AN-12-H5, are known to have similar mutations in the 3A protein-encoding region causing resistance to enviroxime (a G5318A [3A-Ala70Thr] mutation in poliovirus [PV]) and are considered enviroxime-like compounds. Recently, antienterovirus activity of a phosphatidylinositol 4-kinase III beta (PI4KB) inhibitor, PIK93, was reported, suggesting that PI4KB is an important host factor targetable by antienterovirus compounds (N. Y. Hsu et al., Cell 141:799-811, 2010). In this study, we analyzed the inhibitory effects of previously identified enviroxime-like compounds (GW5074 and AN-12-H5) and a newly identified antienterovirus compound, T-00127-HEV1, on phosphoinositide (PI) kinases. We found that T-00127-HEV1 inhibited PI4KB activity with a higher specificity for than other PI kinases, in contrast to GW5074, which had a broad specificity for PI kinases. In contrast, AN-12-H5 showed no inhibitory effect on PI4KB activity and only moderate inhibitory effects on PI 3-kinase activity. Small interfering RNA (siRNA) screening targeting PI kinases identified PI4KB is a target of GW5074 and T-00127-HEV1, but not of AN-12-H5, for anti-PV activity. Interestingly, T-00127-HEV1 and GW5074 did not inhibit hepatitis C virus (HCV) replication, in contrast to a strong inhibitory effect of AN-12-H5. These results suggested that PI4KB is an enterovirus-specific host factor required for the replication process and targeted by some enviroxime-like compounds (T-00127-HEV1 and GW5074) and that enviroxime-like compounds may have targets other than PI kinases for their antiviral effect.
AGGREGATION OF DYES BOUND TO POLYANIONS.

* Present address: Department of Biochemistry, Stanford University. This work was done while the author held a John Simon Guggenheim Memorial Fellowship, and was supported in part by a research grant from the National Institutes of Health, RG 4196. 1 Meselson, M. , F. W. Stahl, and J. Vinograd, these PROCEEDINGS, 43, 581 (1957). 2 Meselson, M. , and F. W. Stahl, these PROCEEDINGS, 44, 671 (1958). 3The term "effective density"' refers to the density of the solution when the buoyant forces acting on the solute are zero; more precisely, the effective density is defined by equations (5b) and (17c). 4Butler, J. A. V. , D. J. R. Laurence, A. B. Robins, and K. V. Shooter, Proc. Roy. Soc. (Lond.) A, 250, 1 (1959).
Not all are free‐living: high‐throughput DNA metabarcoding reveals a diverse community of protists parasitizing soil metazoa

Protists, the most diverse eukaryotes, are largely considered to be free‐living bacterivores, but vast numbers of taxa are known to parasitize plants or animals. High‐throughput sequencing (HTS) approaches now commonly replace cultivation‐based approaches in studying soil protists, but insights into common biases associated with this method are limited to aquatic taxa and samples. We created a mock community of common free‐living soil protists (amoebae, flagellates, ciliates), extracted DNA and amplified it in the presence of metazoan DNA using 454 HTS. We aimed at evaluating whether HTS quantitatively reveals true relative abundances of soil protists and at investigating whether the expected protist community structure is altered by the co‐amplification of metazoan‐associated protist taxa. Indeed, HTS revealed fundamentally different protist communities from those expected. Ciliate sequences were highly over‐represented, while those of most amoebae and flagellates were under‐represented or totally absent. These results underpin the biases introduced by HTS that prevent reliable quantitative estimations of free‐living protist communities. Furthermore, we detected a wide range of nonadded protist taxa probably introduced along with metazoan DNA, which altered the protist community structure. Among those, 20 taxa most closely resembled parasitic, often pathogenic taxa. Therewith, we provide the first HTS data in support of classical observational studies that showed that potential protist parasites are hosted by soil metazoa. Taken together, profound differences in amplification success between protist taxa and an inevitable co‐extraction of protist taxa parasitizing soil metazoa obscure the true diversity of free‐living soil protist communities.
Increase in serum selenium levels in Finnish children and young adults during 1980-1986: a correlation between the serum levels and the estimated intake.

Serum selenium concentrations of Finnish children and adolescents (ages: 3, 6, 9, 12, 15 and 18 years) were analysed in 1980. The sample included 1706 subjects from five different areas, each containing rural and urban sectors. The serum selenium concentration levels were compared to the intakes of energy, selenium, protein, fat and carbohydrate estimated by a dietary survey (in a total of 1090 subjects from the 1706). In 1986 corresponding data were obtained from 280 of the subjects from the 1980 sample. The mean intake of selenium from food in 1980 ranged from 12 to 23 micrograms per day for the different age groups. In 1986, after the addition of selenium to fertilizers, the mean daily intake of selenium ranged from 69 to 82 micrograms per day for the groups of subjects, who were 9, 12, 15, 18, 21 and 24 years old by that time. In 1980, the children aged 3 and 6 years had lower selenium concentrations in their sera compared to the other age groups. However, serum selenium levels were higher in the Tampere and Oulu areas. In 1986 the selenium concentrations in sera increased with age (9-21-year-olds) and no regional differences were found. The selenium levels in sera were higher in 1986 than in 1980 due to the increased intake after the addition of selenium to fertilizers used in Finland. The increase in selenium levels between the 1980 and 1986 studies were, on the average, 45%. (ABSTRACT TRUNCATED AT 250 WORDS)
Spatial Judgments from Different Vantage Points

Todorovic (2008) reported that there are systematic errors in the perception of 3-D space when viewing 2-D linear perspective drawings depending on the observer’s vantage point. Because Todorovic’s findings were restricted to the horizontal plane, the current study was designed to determine whether the magnitude of these errors would be similar in the vertical plane. Participants viewed a 2D image containing rows of columns aligned on parallel converging lines receding to a vanishing point. They were asked to judge where in the physical room the next column should be placed. The results support Todorovic (2008) in that systematic deviations in the spatial judgments depended on vantage point for both the horizontal and vertical planes. However, the pattern of deviation differed between the two planes. While judgments in both planes failed to compensate adequately for the vantage point shift, the vertical plane induced greater distortions of the stimulus image itself within each vantage point.
A software architecture for the deployment of executable transformation models

Emergency management involves collaboration among different operators (e.g. policemen, firemen, medics) on critical and dangerous situations (e.g. fires, floods). Real-time elaborations of a large amount of information and knowledge are needed to automate control and decision making processes. In this scenario raw data are captured and processed through a chain of activities (filtering, fusion, classification) generating abstract information that is selected, diffused and presented to interested users. These activities can be turned into the interpretation of executable transformation models, abstract representations of input-output transformations which can be coded on a calculator. Executable transformation models might not be static; but they may be dynamically generated by observing and processing incoming data. From the architectural point of view the dynamic model generation implies the existence of mechanisms for the dynamic deployment of the executable transformation models. In this paper we present a software architecture aimed at providing these mechanisms.
Small potent ligands to the insulin‐regulated aminopeptidase (IRAP)/AT4 receptor

Angiotensin IV analogs encompassing aromatic scaffolds replacing parts of the backbone of angiotensin IV have been synthesized and evaluated in biological assays. Several of the ligands displayed high affinities to the insulin‐regulated aminopeptidase (IRAP)/AT4 receptor. Displacement of the C‐terminal of angiotensin IV with an o‐substituted aryl acetic acid derivative delivered the ligand 4, which exhibited the highest binding affinity (Ki = 1.9 nM). The high affinity of this ligand provides support to the hypothesis that angiotensin IV adopts a γ‐turn in the C‐terminal of its bioactive conformation.
Intracellular pH changes during the cell cycle in Tetrahymena

The equilibrium distribution of 5,5‐dimethyloxazoladine 2,4‐dione (DMO) between intra‐ and extracellular volume was used to estimate intracellular pH (pHi) in Tetrahymena pyriformis. In control experiments, DMO was found to equilibrate rapidly in response to a pH gradient. Under normal growth conditions, pHi was constant over a finite range of external pH, being maintained near pH 7.1 over the external pH range 5.25 to 7.3. This same range of external pH was also optimal for growth. pHi was monitored during the cell cycle of a synchronous population of T. pyriformis GL. The cells were synchronized either by starvation/refeeding or heat shock. Under both conditions, there were two alkaline shifts of approximately 0.4 pH units per cell cycle. These shifts in pH retained a constant remporal relationship to S phase and were not affected by changes in the time, duration, or magnitude of cytokinesis.
Collagenolytic activity in amphibian tissues: a tissue culture assay.

ing from this point of view, one could say that we have built and tested a crude membrane model in which such a phenomenon might be observed, and that thus far the binding energies agree satisfactorily with those calculated from in vivo experiments only when the model contains lipid. In so far as we understand the behavior of the model, it does not permit us to state whether the interactions occur primarily between lipid film and narcotic or between water and narcotic, facilitated by the presence of lipid. In either interpretation, our data suggest that lipid plays an essential role and show that even substances which are not intrinsically surface active can have profound effects when the composition of the interfacial phase is suitably chosen. "7 The sensitivity of the model to inert gases and the quantitative similarity of its reactions to their biological effect suggest that further studies of its changes of physical state under narcotics may be very informative.
Genetic Selection of Cyclic Peptide Dam Methyltransferase Inhibitors

We report the development of a transposition based genetic selection methodology used to uncover three cyclic peptide inhibitors of the E. coli methyltransferase. The activity of the selected cyclic peptides was confirmed in vivo and in vitro. The IC50 of the most active cyclic peptide (SGWYVRNM, shown in the figure) was comparable to that of the known methyltransferase inhibitor, sinefungin.
The Deterministic Dynamic Product Cycling Problem

Certain manufacturing situations involve a small number of items produced sequentially on the same facility with high changeover cost. Production schedules are characterized by long runs, and individual items are produced infrequently. At the same time, seasonal demand patterns require that the items be maintained in inventory in the right mix. This paper presents alternative formulations of this problem. It uses a Lagrangean relaxation approach to decouple the problem and provide lower bounds used in a branch and bound algorithm. Some experimental computations on small problems are reported.
Tc-99m HMPAO SPECT in the evaluation of Alzheimer’s disease: correlation between neuropsychiatric evaluation and CBF images

The purpose of this study was to evaluate the effects of various covariants on the distribution pattern of Tc-99m HMPAO in patients with Alzheimer’s disease by correlation analysis. Twenty patients with Alzheimer’s disease and 15 age matched normal subjects participated. Tc-99m HMPAO brain SPECT and xray computed tomography (CT) were acquired for each subject. SPECT images were transformed to a standard size and shape by automated image registration (AIR) and were used for group comparison by means of SPM96. Voxel based covariance analysis was performed on standardised images taking the age of patients, severity of disease (clinical dementia rating scale, mini mental state examination, physical self maintenance scale), and atrophy indices as variables. There was significantly decreased regional cerebral blood flow (rCBF) in the frontal, parietal, and temporal regions in the patient group (p<0.001), more marked in those patients having severe dementia. Covariance analysis disclosed that aging and severity of disease have a pronounced effect on rCBF, especially that of the left parietal region.
An Initial Study on Normal Commensel Flora of Throat

Introduction: The normal throat flora of humans is complex and consists of several species of bacteria. Materials &Methods: The study aimed at finding out the normal commensel flora of throat of healthy individual in a tertiary care hospital with 157 selected individuals of different ages and both sexes over a period of three months (January 2015 to March2015). Diagnosed cases of immunocompromisation were excluded from the study. Aseptically collected throat swabs were processed for microbiological workup as per standard protocols. Speciation and antimicrobial susceptibility testing of the isolates were done by VITEK-2 Advanced Expert System. Data were analyzed as per standard statistical methods. Results: Amongst study population, Staphylococcus aureus was isolated in 71 cases (45.22%), viridans group of Streptococcus (Streptococcus mitis )was isolated from 93 cases (59.23%)and Diphtheroids were isolated in 29 cases (18.47%). Moraxella sppwere isolated in 17 cases(10.82%). Streptococcus pneumoniae was isolated in 13 cases (0.08%) and Candida albicanswas isolated in 9 cases(0.057%). Polymicrobial isolations were associated in 139 cases (88.53%). All of the Streptococcus isolates were sensitive to Penicillin and Erythromycin. All isolated Staphylococcus aureus were sensitive to Vancomycin and Linezolid. Amongst 71 isolated Staphylococcus aureus, 19 were Methicillin resistant (26.76%). Candida isolates were sensitive to Fluconazole and Itraconazole. Candida albicans was isolated from study group belonging to below 10 years and above 60 years. Moraxella spp. was isolated from the age group of 21years to 40 years. ViridansStreptococcus and Mthicillin Resistant Staphylococcus aureus were isolated from the study population aged ≥10 years. Conclusion: Viridans group of Streptococcus is the leading microbe to form the commensal flora of throat specially after 10 years.