Miracle-dz/UniFAR-FTUs huggingface dataset:
Chaperone gp96-independent Inhibition of Endotoxin Response by Chaperone-based Peptide Inhibitors*

Background: gp96 is a master chaperone for TLRs. A gp96-derived peptide (PIER) inhibits the LPS response. The underlying mechanism is unclear. Results: PIER inhibits LPS binding and signaling independently of gp96. It targets HSP90 and has anticancer activity. Conclusion: PIERs inhibit LPS responsiveness and tumor growth in a gp96-independent manner. Significance: This study facilitates the development of HSP90-based inhibitors to treat inflammation and cancer. HSP90 chaperones a large number of proteins, and it plays essential roles in multiple signaling pathways to maintain protein homeostasis in the cytosol. In addition, HSP90 has been implicated in mediating recognition of lipopolysaccharide (LPS). However, no pharmacologic agents have been developed to interrogate this pathway. Herein we demonstrate that a peptide-based inhibitor that was previously reported to inhibit the master Toll-like receptor-chaperone gp96, an endoplasmic reticulum paralog of HSP90, in fact blocks HSP90-LPS interaction. It inhibited the binding of LPS to the cell surface of both wild type and gp96-null cells and thereby abrogated the cellular response to LPS but not to other Toll-like receptor ligands. We also generated a series of peptide derivatives (named peptide inhibitors of endotoxin responsiveness (PIERs)) from the N-terminal helix structure of HSP90 and demonstrated their effectiveness in blocking LPS activity. PIER inhibition of LPS signaling was partially reversed by CD14 expression. Moreover, we found that a cell-permeable PIER abrogated HSP90 function and caused degradation of multiple known HSP90 client proteins in cancer cells. Thus, targeting HSP90 is a promising modality for treatment of both LPS-mediated pathology and cancer.
Simulation of replicas for performance assessment of web services

In addition to the configuration of hardware resources, replicas of these resources have an impact on the performance metrics of WA/WS (Web Applications/Web Services). Replicas play a significant role in improving the Quality of Services of Web Services published. It is beneficial in managing resource sharing and useful to moderate the energy consumed in IT environments. In the last decade, the demand for Business-to-Business (B2B) applications has increased and as a consequence, the number of web services has been increased persistently. The number of replicas to be deployed must be sufficient. However, it should not be more than what is expected since the replication technique clearly requires extra processing time and space. In order to meet the performance objective, hence, it is essential to identify the adequate number of replicas for resources.
CYUT at IJCNLP-2017 Task 3: System Report for Review Opinion Diversification

Review Opinion Diversification (RevOpiD) 2017 is a shared task which is held in International Joint Conference on Natural Language Processing (IJCNLP). The shared task aims at selecting top-k reviews, as a summary, from a set of re-views. There are three subtasks in RevOpiD: helpfulness ranking, rep-resentativeness ranking, and ex-haustive coverage ranking. This year, our team submitted runs by three models. We focus on ranking reviews based on the helpfulness of the reviews. In the first two models, we use linear regression with two different loss functions. First one is least squares, and second one is cross entropy. The third run is a random baseline. For both k=5 and k=10, our second model gets the best scores in the official evaluation metrics.
Perceived versus objective breast cancer risk in diverse women.

BACKGROUND Prior research suggests that women do not accurately estimate their risk for breast cancer. Estimating and informing women of their risk is essential for tailoring appropriate screening and risk reduction strategies. METHODS Data were collected for BreastCARE, a randomized controlled trial designed to evaluate a PC-tablet based intervention providing multiethnic women and their primary care physicians with tailored information about breast cancer risk. We included women ages 40-74 visiting general internal medicine primary care clinics at one academic practice and one safety net practice who spoke English, Spanish, or Cantonese, and had no personal history of breast cancer. We collected baseline information regarding risk perception and concern. Women were categorized as high risk (vs. average risk) if their family history met criteria for referral to genetic counseling or if they were in the top 5% of risk for their age based on the Gail or Breast Cancer Surveillance Consortium Model (BCSC) breast cancer risk model. RESULTS Of 1,261 participants, 25% (N=314) were classified as high risk. More average risk than high risk women had correct risk perception (72% vs. 18%); 25% of both average and high risk women reported being very concerned about breast cancer. Average risk women with correct risk perception were less likely to be concerned about breast cancer (odds ratio [OR]=0.3; 95% confidence interval [CI]=0.2-0.4) while high risk women with correct risk perception were more likely to be concerned about breast cancer (OR=5.1; 95%CI=2.7-9.6). CONCLUSIONS Many women did not accurately perceive their risk for breast cancer. Women with accurate risk perception had an appropriate level of concern about breast cancer. Improved methods of assessing and informing women of their breast cancer risk could motivate high risk women to apply appropriate prevention strategies and allay unnecessary concern among average risk women.
Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species

Simian retroperitoneal fibromatosis (RF) is a vascular fibroproliferative neoplasm which has many morphological and histological similarities to human Kaposi's sarcoma (KS). Like epidemic KS in AIDS patients, RF is highly associated with an immunodeficiency syndrome (simian acquired immunodeficiency syndrome [SAIDS]) caused by a retrovirus infection. Recently, a new gammaherpesvirus, called Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8), has been identified in KS tumors, suggesting that KS has a viral etiology. Our previous experimental transmission studies and epidemiological data suggest that RF also has an infectious etiology. In order to determine whether a similar virus is also associated with RF, we have assayed for the presence of an unknown herpesvirus using degenerate PCR primers targeting the highly conserved DNA polymerase genes of the herpesvirus family. Here we provide DNA sequence evidence for two new herpesviruses closely related to KSHV from RF tissues of two macaque species, Macaca nemestrina and Macaca mulatta. Our data suggest that KSHV and the putative macaque herpesviruses define a new group within the subfamily Gammaherpesvirinae whose members are implicated in the pathogenesis of KS and KS-like neoplasms in different primate species.
Rasgos configuradores de la Generación Interactiva en España

La Generacion Interactiva se caracteriza por el elevado grado de posesion y acceso inmediato a diversos dispositivos tecnologicos. Esta realidad supone para los menores una nueva forma de invertir el tiempo, de compartir experiencias, de vivir la vida familiar, escolar y social, que, al menos en la forma, poco tiene que ver con las de generaciones precedentes. El objetivo de esta comunicacion es ofrecer una mirada detallada sobre ese nuevo lugar que ocupan las pantallas para este grupo de edad. Internet, telefonos moviles, videojuegos y television son las cuatro pantallas analizadas desde una perspectiva integrada que permite conocer como interactuan todas ellas sobre un unico sujeto. La inclusion de variables familiares y escolares en la recogida de datos permite tambien dibujar un perfil mas fiel del uso real que los menores hacen de las nuevas tecnologias. Sus valoraciones y los riesgos reales y percibidos matizan las innumerables ventajas que pueden proporcionar estas pantallas. Identificar los rasgos claves de esta generacion, desde una perspectiva comunicativa, es esencial para establecer estrategias de comunicacion eficaces con este publico, al tiempo que se hace necesario para que las administraciones publicas y las instituciones privadas puedan actuar con responsabilidad a la hora de dirigirse a los menores. Equipados, autonomos, autodidactas, movilizados, son algunos de estos rasgos configuradores de la generacion interactiva. La relacion social y el ocio son los motores principales en su relacion con la tecnologia, y su elevado conocimiento de las herramientas dificulta en ocasiones la mediacion educativa que puedan proveer padres y profesores. El proyecto Generaciones Interactivas, una iniciativa del Foro Generaciones Interactivas, fundado por Telefonica, la Universidad de Navarra y la Organizacion Universitaria Interamericana, ha desarrollado, durante el ano 2009, una investigacion en Espana entre 13.000 menores, de 6 a 18 anos. Esta comunicacion fundamenta sus propuestas en los datos obtenidos 2 en el curso de esta investigacion, y plantea para su discusion los retos comunicativos y de investigacion que emergen del analisis detallado de esta realidad que afecta a los ninos y adolescentes en la Sociedad de la Informacion
Mental disorders as complex networks : An introduction and overview of a network approach to psychopathology

Mental disorders have traditionally been conceptualized as latent variables, which impact observable symptomatology. Recent alternative approaches, however, view mental disorders as systems of mutually reinforcing symptoms, and utilize network models to analyze the structure of these symptom-symptom interactions. This paper gives an introduction to and overview of the network approach to psychopathology, as it has developed over the past years.
A Swedish Clause Grammar And Its Implementation

The paper is concerned with the notion of clause as a basic, minimal unit for the segmentation and processing of natural language. The first part of the paper surveys various criteria for clausehood that have been proposed in theoretical linguistics and computational linguistics, cind pro­ poses that a clause in English or Swedish or any other natural language can be defined in structural terms at the surface level as a regular expression of syntactic categories, equivalently, as a set of sequences of word classes, a possibility which has been explicitly denied by Harris (1968) and later transformational grammarians. The second part of the paper presents a grammar for Swedish clauses
Superconducting transmission lines for use in a 3 He dilution refrigerator

We compare two superconducting transmission lines for use in a He dilution refrigerator using a NbTi wire inner conductor with NbTi foil and CuNi tubing outer conductors. The heat transfer is calculated using the Wiedermann-Franz Law, and the impedance and power loss are measured using a network analyzer at room temperature and at 4K. The transmission line with CuNi tubing is easy to construct, transfers little heat, and has an impedance closer to 50 Ω than the line with NbTi foil outer conductor.
Apprenticeships for the XXI Century: A Model for Latin America and the Caribbean?

This study intends to decompose apprenticeships. First, based on an extensive review of existing literature, it proposes a formal definition of apprenticeships that differentiates this type of training modality from other types of skills training. Second, it explores core elements and principles in depth that are central to apprenticeship programs- both in terms of their design and delivery- and presents examples of best practices from around the world that LAC countries can use as potential instruments to apply within their contexts. Third, it assesses the status of apprenticeship-type programs in LAC and provides an overview of the specific challenges these programs face in the region. By providing potential solutions to address them, the study sheds light on the transferability of long-standing apprenticeship models (Germany, Austria, Australia, the United Kingdom, among others) and, more so, of the aforementioned core elements and principles to the LAC context. Finally, in an attempt to close the gap between the theoretical and the practical, it provides a hands-on tool kit for policy makers and employers to ask pertinent questions when considering the design of new programs or the revamping of existing ones.
Evidence of effectiveness of audit in improving care is growing

EDITOR,—Andrew Miles and colleagues' letter about audit exemplifies the confusion in the debate about the achievements of the national audit programme.1 There are misunderstandings about the true nature of audit among both clinicians and researchers, and this results in opinions that are poorly supported by evidence. In evaluating the impact of audit it is essential to distinguish between audit as a method and the way in which it has been implemented. Although only …
STRUCTURE OF THE MALE GAMETOPHYTE IN GYMNOSPERMS

Analysis of the morphological nature of the gymnospermous male gametophyte has been based on evidence from fossil gymnosperms, on a comparative survey of living vascular plants, and on ontogeny within the various families of the gymnosperms. Although fossil coniferous and taxad pollen is unknown, the fossil pollen of other gymnosperms is rather uniform in the presence of a layer of parietal cells (presumably an antheridial jacket) which surrounds a central, probably spermatogenous region. The same organization occurs in endosporal gametophytes of lower Tracheophyta of the present day. Reduction in the number of vegetative prothallial cells appears to have occurred early in gymnosperm evolution, so that the male gametophyte may be regarded essentially as a reduced antheridium. Between the fossil gymnosperms and the present forms there has occurred a reduction of the antheridial jacket and the corresponding production of a pollen tube. For various reasons, the balance of probability is in favour of a homology between the antheridial jacket of Palaeozoic gymnosperms and the tube cell of modern gymnosperms.
Redistribution of Microcirculatory Blood Flow within the Intestinal Wall during Sepsis and General Anesthesia

Background Hypoperfusion of the intestinal mucosa remains an important clinical problem during sepsis. Impairment of the autoregulation of microcirculatory blood flow in the intestinal tract has been suggested to play an important role in the development of multiple organ failure during sepsis and surgery. The authors studied microcirculatory blood flow in the gastrointestinal tract in anesthetized subjects during early septic shock. Methods Eighteen pigs were intravenously anesthetized and mechanically ventilated. Regional blood flow in the superior mesenteric artery was measured with ultrasound transit time flowmetry. Microcirculatory blood flow was continuously measured with a six-channel laser Doppler flowmetry system in the mucosa and the muscularis of the stomach, jejunum, and colon. Eleven pigs were assigned to the sepsis group, while seven animal served as sham controls. Sepsis was induced with fecal peritonitis, and intravenous fluids were administered after 240 min of sepsis to alter hypodynamic sepsis to hyperdynamic sepsis. Results In the control group, all monitored flow data remained stable throughout the study. During the hypodynamic phase of sepsis, cardiac output, superior mesenteric artery flow, and microcirculatory blood flow in the gastric mucosa decreased by 45%, 51%, and 40%, respectively, compared to baseline (P < 0.01 in all). Microcirculatory blood flow in the muscularis of the stomach, jejunum, and colon decreased by 55%, 64%, and 70%, respectively (P < 0.001 in all). In contrast, flow in the jejunal and colonic mucosa remained virtually unchanged. During the hyperdynamic phase of sepsis, there was a threefold increase in cardiac output and superior mesenteric artery flow. Blood flow in the gastric, jejunal, and colonic mucosa also increased (22%, 24%, and 31% above baseline, respectively). Flow in the muscularis of the stomach returned to baseline, while in the jejunum and colon, flow in the muscularis remained significantly below baseline (55% and 45%, respectively, P < 0.01). Conclusions It appears that in early septic shock, autoregulation of microcirculatory blood flow is largely intact in the intestinal mucosa in anesthetized pigs, explaining why microcirculatory blood flow remained virtually unchanged. This may be facilitated through redistribution of flow within the intestinal wall, from the muscularis toward the mucosa.
Reference frame selection for loss-resilient depth map coding in multiview video conferencing

Multiview video in "texture-plus-depth" format enables decoder to synthesize freely chosen intermediate views for enhanced visual experience. Nevertheless, transmission of multiple texture and depth maps over bandwidthconstrained and loss-prone networks is challenging, especially for conferencing applications with stringent deadlines. In this paper, we examine the problem of loss-resilient coding of depth maps by exploiting two observations. First, different depth macroblocks have significantly different error sensitivities with respect to the reconstructed images. Second, unlike texture, the relative overhead of using reference pictures with large prediction distance is low for depth maps. This motivates our approach of assigning a weight to represent the varying error sensitivity of each macroblock and using such weights to guide selection of reference frames. Results show that (1) errors in depth maps in sequence with high motion yields significant drop in quality in reconstructed images, and (2) that the proposed scheme can efficiently maintain the quality of reconstructed images even at relatively high packet loss rates of 3-5%.
A compact 5G antenna printed on manganese zinc ferrite substrate material

In this article, a compact antenna is proposed using new microwave dielectric ceramic (MDC) substrate for 5G millimetre wave application. The distinctive novelties exhibited in this article are used of MDCs substrate material for antenna designing and performances analysis for wireless communication. The proposed antenna achieves impedance bandwidth of 2.66 GHz (from 27.235 GHz to 29.895 GHz), which covers the top interest (28 GHz) for 5G mm-wave in some countries and trials have been reported. The proposed antenna attains average gain of 5.44 dB and 93% of radiation efficiency with antenna size of 1. 32λ × 1. 32λ × 0. 094λ.
Pandemic (H1N1) 2009 Influenza Virus Infection in A Survivor Who Has Recovered from Severe H7N9 Virus Infection, China

We firstly report a patient who presented with severe complications after infection with influenza A(H1N1) pdm2009, more than 1 year after recovery from severe H7N9 virus infections. The population of patients who recovered from severe H7N9 infections might be at a higher risk to suffer severe complications after seasonal influenza infections, and they should be included in the high-risk populations recommended to receive seasonal influenza vaccination.
Abrupt Climate Change and Transient Climates during the Paleogene: A Marine Perspective

Detailed investigations of high latitude sequences recently collected by the Ocean Drilling Program (ODP) indicate that periods of rapid climate change often culminated in brief transient climates, with more extreme conditions than subsequent long term climates. Two examples of such events have been identified in the Paleogene; the first in latest Paleocene time in the middle of a warming trend that began several million years earlier: the second in earliest Oligocene time near the end of a Middle Eocene to Late Oligocene global cooling trend. Superimposed on the earlier event was a sudden and extreme warming of both high latitude sea surface and deep ocean waters. Imbedded in the latter transition was an abrupt decline in high latitude temperatures and the brief appearance of a full size continental ice-sheet on Antarctica. In both cases the climate extremes were not stable, lasting for less than a few hundred thousand years, indicating a temporary or transient climate state. Geochemical and sedimentological evidence suggest that both Paleogene climate events were accompanied by reorganizations in ocean circulation, and major perturbations in marine productivity and the global carbon cycle. The Paleocene-Eocene thermal maximum was marked by reduced oceanic turnover and decreases in global $$\delta^{13}C $$ and in marine productivity, while the Early Oligocene glacial maximum was accompanied by intensification of deep ocean circulation and elevated $$\delta^{13}C $$ and productivity. It has been suggested that sudden changes in climate and/or ocean circulation might occur as a result of gradual forcing as certain physical thresholds are exceeded. We investigate the possibility that sudden reorganizations in ocean and/or atmosphere circulation during these abrupt transitions generated short-term positive feedbacks that briefly sustained these transient climatic states.
Functional Taxonomy of Bacterial Hyperstructures

SUMMARY The levels of organization that exist in bacteria extend from macromolecules to populations. Evidence that there is also a level of organization intermediate between the macromolecule and the bacterial cell is accumulating. This is the level of hyperstructures. Here, we review a variety of spatially extended structures, complexes, and assemblies that might be termed hyperstructures. These include ribosomal or “nucleolar” hyperstructures; transertion hyperstructures; putative phosphotransferase system and glycolytic hyperstructures; chemosignaling and flagellar hyperstructures; DNA repair hyperstructures; cytoskeletal hyperstructures based on EF-Tu, FtsZ, and MreB; and cell cycle hyperstructures responsible for DNA replication, sequestration of newly replicated origins, segregation, compaction, and division. We propose principles for classifying these hyperstructures and finally illustrate how thinking in terms of hyperstructures may lead to a different vision of the bacterial cell.
iDARE—a reference architecture for integrated software environments

Traditionally, software development environments have tended to treat a system's development‐time activities separately from its run‐time. After a system is in operation, it frequently needs to be maintained and evolved. In traditional environments, this results in frequent relocations of a system between the disjoint development and run‐time environments, which is undesirable for several reasons. A more effective solution is to couple the development and run‐time environments to directly monitor and adapt running systems. Given the growing need for interaction between development‐time and run‐time aspects of modern software systems, it is important to understand development and run‐time environments, and their relationship. To this end, we study and classify a wide range of software development environments on the basis of their level of interaction with the corresponding run‐time environments. Particularly, we identify, study, and characterize Self‐Adaptive Life‐cycle Environments (SALEs), an emerging class of modern development environments that are tightly integrated with run‐time environments. We reify our study of the development environments into a novel reference architecture, iDARE, that captures and differentiates the architectures of software environments – from those, such as traditional development environments, that have no interaction with the run‐time environments, to the ones, such as SALEs, that are tightly integrated with the run‐time environments. We use iDARE to highlight several shortcomings of existing SALEs. Adherence to iDARE has the potential to improve certain quality properties of the integrated development and run‐time environments, such as adaptability, fault‐tolerance, robustness, availability, and resource consumption. We identify a number of opportunities for future research. Copyright © 2013 John Wiley & Sons, Ltd.