Miracle-dz/UniFAR-FTUs huggingface dataset:
Zur Aktivität der alkalischen Phosphatase in Serum und Knochen von zinkdepletierten und ‐repletierten Kühen

Zusammenfassung In einem Versuch mit funf laktierenden Milchkuhen wurden unter Verwendung einer halbsynthetischen Diat Aktivitatsveranderungen der alkalischen Phosphatase in Serum, Knochen und Milch bei Zink-Depletion und -Repletion untersucht. Die alkalische Phosphatase im Serum sank wahrend einer sechswochigen Depletion (6 mg Zn/kg TS) nur bis auf 82% des Ausgangswertes, der aber infolge zu geringer Zinkzufuhr vor Versuchsbeginn bereits erniedrigt war. Nach 19wochiger Depletionsdauer erfolgte eine weitere Aktivitatsminderung auf 43 % des Ausgangswertes. Durch Zinkzulagen in der Repletion konnte die Aktivitat uberaus deutlich und auf wesentlich hohere Werte als zu Versuchsbeginn gesteigert werden. Damit war der Repletionseffekt ebenso stark wie beim Zinkgehalt in Serum und Milch. Die alkalische Serumphosphatase deutete eine Leistungsabhangigkeit an und stellt einen empfindlichen Indikator des Zinkstatus dar. Die Aktivitat der alkalischen Phosphatase im Knochen (Tuber coxae) fiel nach 6 Wochen Zinkdepletion auf 68 % des Ausgangswertes ab. Auf die alkalische Phosphatase in der Milch hatte die Zinkversorgung keinen Einflus.
FAKTOR-FAKTOR YANG MELATARBELAKANGI KEJADIAN ABORTUS IMMINENS PADA IBU HAMIL DI SUKADANA KABUPATEN KAYONG UTARA

ABSTRAK Abortus imminens adalah peristiwa terjadinya perdarahan pervaginam pada trimester pertama kehamilan. Dari 8 puskesmas yang berada di Kabupaten Kayong Utara, Sukadana menempati peringkat pertama dibanding puskesmas lain dengan total angka kejadian 32 orang (37,20%) ibu hamil yang mengalami abortus imminens.Berdasarkan hasil survei awal kepada nakes dan bumil serta penelitian terdahulu terdapat empat aspek yang menjadi fokus penelitian yakni pengetahuan, stress, tindakan pencegahan infeksi keputihan dan tindakan pelayanan. Penelitian menggunakan pendekatan kualitatif dengan studi fenomenologi yang dilakukan kepada 5 orang ibu hamil yang mengalami abortus imminens, 5 orang keluarga terdekat dan 3 orang tenaga kesehatan. Hasil penelitian menunjukkan bahwa Pengetahuan ibu hamil masih rendah mengenai kehamilan, adanya Stress yang dialami pada saat kehamilan, Tindakan yang salah dalam pencegahan infeksi keputihan serta Tindakan pelayanan kesehatan yang kurang memadai di Sukadana Kabupaten Kayong Utara. Disarankan pada ibu hamil lebih menjaga kesehatan, mengatur pola makan, menghindari stress, melakukan pemeriksaan kehamilan secara teratur untuk meminimalkan risiko terjadinya abortus imminens. Kata Kunci : Abortus Imminens, Ibu Hamil, Orang Terdekat, Tenaga Kesehatan, Pengetahuan, Stress, Infeksi (keputihan), Tindakan Pelayanan. ABSTRACT Threatened abortion is an event occurence of vaginal bleeding in the first trimester of pregnancy. 8 health Center located in the District of North Kayong, Sukadana ranked first compared to other health center with a total incidence of 32 people (37,20%) pregnant women a have threatened abortion. Based on the initial survey results for health workes and pregnant women as well previous research, there are four aspects of the study focused on the knowledge, stress, infection prevention measures whitish and health care measures. The Research used a qualitative approach with a phenomenological study conducted for 5 pregnant women having threatened abortion, 5 immediate family and 3 health workes. The results showed that pregnant women remains low knowledge about pregnancy, the presence of stress uring pregnancy, wrong action in the prevention of infection whitish and measures health services in Sukadana District of North Kayong. Recommended for pregnancy women, more keeping do health, set a pattern eat, avoid stress, a Medical examination regulary for minimize rial threatened abortion. Keywords : Threatened Abortion, Pregnancy Women, Immediate Family, Health Workes, Knowledge, Stress, whitish Infeksion, Health Services.
The Pattern of Cell Proliferation during Pearl Sac Formation in the Pearl Oyster

In pearl aquaculture with the pearl oyster Pinctada fuca ta martensii, a tissue fragment from the pallial zone of one pearl oyster's mantle (donor) is implanted into the gonad of other oysters (recipients). A small inorganic bead made from the shell of a freshwater mussel is also inserted and put in contact with the allograft. After the operation, the outer epithelial cells of the mantle fragment become squa mous and emigrate to encapsulate the bead. They eventual ly form a follicle called a "pearl sac" surrounding the bead, often become cuboidal in shape, and start to form pearl layers on the bead.1) The outer epithelium of the pallial zone of the pearl oys ter mantle is composed of three types of cells; mucous cells, cells with large acidophilic granules, and outer epider mal cells, the latter of which is the dominant cell type.2,3) The pearl sac epithelium is also a monolayer of these three types of cells.1,4) Among these three cell types, the outer epidermal cells are thought to proliferate in the course of emigration and pearl sac formation.1) However, the details of cell multiplication, e.g. distribution and frequency of mitotic cells, have not yet been clarified. The behavior of the other two cell types in the course of pearl sac forma tion remains uncertain, although they have been reported to appear in the pearl sac epithelium in later phases of its formation. " Proliferation of connective tissue cells in the wound site can also be expected to occur as part of the wound healing process, but this has not been examined. Studies of these issues will facilitate a better understanding and control of pearl sac formation.
Accuracy of Noninvasive Fibrosis Scoring Systems in African American and White Patients With Nonalcoholic Fatty Liver Disease

OBJECTIVES: Nonalcoholic fatty liver disease fibrosis score (NFS), fibrosis-4 (FIB-4) score, aspartate aminotransferase (AST)-to-platelet ratio index (APRI) score, and AST–alanine aminotransferase (ALT) ratio are noninvasive fibrosis scoring systems for the staging of liver fibrosis in patients with chronic liver disease. METHODS: In a large cohort of patients with nonalcoholic fatty liver disease, we compared AST–ALT ratio, NFS, FIB-4 score, and APRI score in predicting advanced fibrosis (defined as fibrosis stage ≥ 3) in histologically confirmed African American (AA) and white patients. We identified 907 patients: 677 (74.6%) white and 230 (25.3%) AA patients with nonalcoholic fatty liver disease. RESULTS: Of the 907 patients, 115 (12.8%) patients had advanced fibrosis (stages 3 and 4) in the total cohort: 6 (2.6%) AAs, and 109 (16.2%) whites. In AAs, the area under the receiver operating characteristic (area under the curve) for predicting advanced fibrosis was 0.58 by NFS, 0.86 by APRI score, 0.77 by FIB-4 score, and 0.65 by AST–ALT ratio. In whites, the area under the receiver operating characteristic for predicting advanced fibrosis was 0.82 by NFS, 0.82 by APRI score, 0.88 by FIB-4 score, and 0.76 by AST–ALT ratio. In the AA population, NFS > 0.675, FIB-4 score > 2.67, and APRI score > 1.5 each has a negative predictive value of 98%, whereas the negative predictive values in whites are 91%, 88%, and 85%, respectively. DISCUSSION: Noninvasive fibrosis scoring systems can reliably exclude advanced fibrosis in both AAs and whites and have acceptable discriminatory ability to predict advanced fibrosis in whites. The utility of noninvasive fibrosis scoring systems in predicting advanced fibrosis in AAs needs further validation in a larger multicenter cohort.
Evaluation of Bacillus species as probiotics.

Due to the beneficial effects to health, probiotics have started to increasingly use as food supplement or for the treatment of infectious disease as well as in various food products, and this has led the researchers to make new studies. Bacillus species can show probiotic properties via their spores and metabolites (enzyme, antimicrobial substances etc.), and with these features, they attract the attention of researchers. Recently, several studies have been carried out related to evaluation of these species as probiotics and it is particularly investigated whether these bacteria are safe to use by human. In this study, behavior of Bacillus species in gastrointestinal tract, their mechanisms of action as probiotics, and their possibilities of usage were reviewed.
Impact of Combined Theory-Based Intervention on Psychological Effects and Physical Activity among Chinese Adolescents

Purpose: The current study was intended to assess the effect of a facilitated behavioral intervention based on the extended theory of planned behavior (TPB) on psychological constructs and physical activity among adolescents over a period of eight weeks. Methods: Students (n = 51, 12 ± 0.3 years of age) in the seventh grade at a junior middle school in China were randomly assigned to two groups: the intervention group (n = 24) and the control group (n = 27). Both groups were pre- and post-tested with the related psychological constructs of the extended TPB, along with behavioral measures of the Physical Activity Scale and ActiGraph accelerometer (model wGT3X-BT). The intervention group took part in 45 min classes once per week for 8 weeks, including five indoor theoretical courses and three outdoor basketball matches. The control group was not required to make any change to their normal school day. Also, 2 × 2 repeated measures analysis of variance (ANOVA) was conducted to compare the differences between the two groups, and then t-test was employed to compare the independent and paired differences. Results: Significant increases in pre–post subjective norms (SN) (p = 0.041, Cohen’s d = 0.62), perceived behavior control (PBC) (p = 0.023, Cohen’s d = 0.72), exercise intention (EI) (p = 0.043, Cohen’s d = 0.61), and self-efficacy (SE) (p = 0.035, Cohen’s d = 1.36) were observed in the intervention group. In addition, participants in the intervention group increased their exercise frequency (p < 0.001, Cohen’s d = 1.25) and intensity (p = 0.028, Cohen’s d = 0.68), especially their time spent on light intensity physical activity (light-PA%; p = 0.031, Cohen’s d = 0.68), and their percentage of sedentary time (SB%) was also reduced (from 68% ± 10% to 58% ± 7%, p < 0.001, Cohen’s d = 1.17). Furthermore, the intervention group showed significantly better performance in PBC (p = 0.032, Cohen’s d = 0.62), EI (p < 0.001, Cohen’s d = 1.32), SE (p < 0.001, Cohen’s d = 1.15), SB% (p < 0.001, Cohen’s d = 1.22), light-PA% (p < 0.001, Cohen’s d = 1.12), and total physical activity (TPA) (p = 0.015, Cohen’s d = 0.72) compared to the control group at the post-test. No significant pre post differences were observed for any psychological or behavioral variables in the control group, except for exercise frequency, but the values were still lower than those in the intervention group after the 8-week intervention (3.70 ± 0.72 versus 3.92 ± 0.83). Conclusion: The combined theory-based intervention was effective at improving psychological constructs and physical activity among seventh-grade adolescents in 8 weeks.
TERRESTRIAL HIGHER PLANTS WHICH HYPERACCUMULATE METALLIC ELEMENTS. A REVIEW OF THEIR DISTRIBUTION, ECOLOGY AND PHYTOCHEMISTRY

This paper reviews the plant geography, ecology, metal tolerance and phytochcmistry of terrestrial higher plants which arc able to accumulate metallic elements in their dry matter to an exceptional degree. The review is limited to the elements Co, Cu, Cr, Pb. Mn. Ni and Zn. Hyperaccumulators of Co, Cu, Cr, Pb and Ni arc here defined as plants containing over 1000 u.g/g (ppm) of any of these elements in the dry matter; for Mn and Zn, the criterion is 10,000 u.g/g (1%). A unifying feature of hypcraccumula ting plants is their general restriction to mineralized soils and specific rock types. Lists of hypcraccumula ting species arc presented for the elements considered. These suggest that the phenomenon is widespread throughout the plant kingdom. For example, 145 hyper-accumulators of nickel are reported: these arc distributed among 6 supcrordcrs, 17 orders, and 22 families and include herbs, shrubs and trees from both the temperate and tropical zones. Although some phylogcnetic relationships emerge, the evolutionary significance of metal hyperaccumulation remains obscure. Phytochemical studies however suggest that hyperaccumulation is closely linked to the mechanism of metal tolerance involved in the successful colonization of metalliferous and otherwise phytotoxic soils. The potentialities of hyperaccumula ting plants in biorccovcry and soil detoxification arc indicated.
Serine 319 phosphorylation is necessary and sufficient to induce a Cx37 conformation that leads to arrested cell cycling

ABSTRACT Connexin 37 (Cx37; protein product of GJA4) expression profoundly suppresses proliferation of rat insulinoma (Rin) cells in a manner dependent on gap junction channel (GJCh) functionality and the presence and phosphorylation status of its C-terminus (CT). In Rin cells, growth is arrested upon induced Cx37 expression and serine 319 (S319) is frequently phosphorylated. Here, we show that preventing phosphorylation at this site (alanine substitution; S319A) relieved Cx37 of its growth-suppressive effect whereas mimicking phosphorylation at this site (aspartate substitution; S319D) enhanced the growth-suppressive properties of Cx37. Like wild-type Cx37 (Cx37-WT), Cx37-S319D GJChs and hemichannels (HChs) preferred the closed state, rarely opening fully, and gated slowly. In contrast, Cx37-S319A channels preferred open states, opened fully and gated rapidly. These data indicate that phosphorylation-dependent conformational differences in Cx37 protein and channel function underlie Cx37-induced growth arrest versus growth-permissive phenotypes. That the closed state of Cx37-WT and Cx37-S319D GJChs and HChs favors growth arrest suggests that rather than specific permeants mediating cell cycle arrest, the closed conformation instead supports interaction of Cx37 with growth regulatory proteins that result in growth arrest. Summary: Cx37-mediated switching between proliferation and growth arrest depends on phosphorylation at serine 319, which induces a protein conformation that likely supports unique interactions with cell cycle regulatory proteins.
A Mobile Health Intervention System for Women With Coronary Heart Disease: Usability Study

Background Coronary heart disease (CHD) is the leading cause of death and disability among American women. The prevalence of CHD is expected to increase by more than 40% by 2035. In 2015, the estimated cost of caring for patients with CHD was US $182 billion in the United States; hospitalizations accounted for more than half of the costs. Compared with men, women with CHD or those who have undergone coronary revascularization have up to 30% more rehospitalizations within 30 days and up to 1 year. Center-based cardiac rehabilitation is the gold standard of care after an acute coronary event, but few women attend these valuable programs. Effective home-based interventions for improving cardiovascular health among women with CHD are vital for addressing this gap in care. Objective The ubiquity of mobile phones has made mobile health (mHealth) behavioral interventions a viable option to improve healthy behaviors of both women and men with CHD. First, this study aimed to examine the usability of a prototypic mHealth intervention designed specifically for women with CHD (herein referred to as HerBeat). Second, we examined the influence of HerBeat on selected health behaviors (self-efficacy for diet, exercise, and managing chronic illness) and psychological (perceived stress and depressive symptoms) characteristics of the participants. Methods Using a single-group, pretest, posttest design, 10 women participated in the 12-week usability study. Participants were provided a smartphone and a smartwatch on which the HerBeat app was installed. Using a web portal dashboard, a health coach monitored participants’ ecological momentary assessment data, their behavioral data, and their heart rate and step count. Participants then completed a 12-week follow-up assessment. Results All 10 women (age: mean 64.4 years, SD 6.3 years) completed the study. The usability and acceptability of HerBeat were good, with a mean system usability score of 83.60 (SD 16.3). The participants demonstrated statistically significant improvements in waist circumference (P=.048), weight (P=.02), and BMI (P=.01). Furthermore, depressive symptoms, measured with the Patient Health Questionnaire-9, significantly improved from baseline (P=.04). Conclusions The mHealth prototype was feasible and usable for women with CHD. Participants provided data that were useful for further development of HerBeat. The mHealth intervention is expected to help women with CHD self-manage their health behaviors. A randomized controlled trial is needed to further verify the findings.
Boosting the extraction of elementary flux modes in genome-scale metabolic networks using the linear programming approach

Abstract Motivation Elementary flux modes (EFMs) are a key tool for analyzing genome-scale metabolic networks, and several methods have been proposed to compute them. Among them, those based on solving linear programming (LP) problems are known to be very efficient if the main interest lies in computing large enough sets of EFMs. Results Here, we propose a new method called EFM-Ta that boosts the efficiency rate by analyzing the information provided by the LP solver. We base our method on a further study of the final tableau of the simplex method. By performing additional elementary steps and avoiding trivial solutions consisting of two cycles, we obtain many more EFMs for each LP problem posed, improving the efficiency rate of previously proposed methods by more than one order of magnitude. Availability and implementation Software is freely available at https://github.com/biogacop/Boost_LP_EFM. Contact fguil@um.es Supplementary information Supplementary data are available at Bioinformatics online.
Biodispersion as a method for removal of hydrocarbon oil from marine aqueous environments

A method for removal of free-floating oil from an aqueous environment by bi o-dispersion and bioutilization comprising the steps of: (i) isolating species/strains of bacteria having an ability to utilize hydrocarbons as the only source of carbon; (ii) admixing the bacteria with fa ty substance and hydrocarbon oil to form an oleophilic suspension comprising a physiologically act ive bacterial culture of hydrocarbonoclastic bacteria, the fatty substance comprising an oleophilic nutrient as a source of nitrogen and phosphorus for the bacteria, and (iii) applying the oleophilic suspe n ion of the bacteria to a free floating oil in an aqueous environment to disperse and remove free-f loating oil therefrom. References Cited [Referenced By] U.S. Patent Documents ( 1 of 1 ) United States Patent 6,267,888 Satyanarayana July 31, 2001 Inventors: Satyanarayana; Ganti (4235 Beaumont Rd., Dover, PA 17315) Appl. No.: 359034 Filed: July 23, 1999 Current U.S. Class: 210/610; 210/611; 210/922; 435/244; 435/248; 435/252.1; 435/253.3; 435/262.5 Intern'l Class: C02F 003/00; C12N 001/20; C12N 001/26 Field of Search: 210/610,611,620,922 435/244,248,261,262,262.5,281,252.1,253.3 3510403 May. , 1970 Laine et al. 3856667 Dec., 1974 Azarowicz. 3871956 Mar., 1975 Azarowics. 3871957 Mar., 1975 Mohan et al. 3883397 May. , 1975 Townsley. Page 1 of 11 United States Patent: 6,267,888 1/5/2005 http://patft.uspto. gov/netacgi/nph -Parser? Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u . Primary Examiner: Simmons; David A. Assistant Examiner: Prince; Fred Attorney, Agent or Firm: Hunton & Williams Parent Case Text PRIORITY OF INVENTION This application claims priority under 35 U.S.C. sctn.119(e) from U . S. Provisional Application No. 60/093,870, filed Jul. 23, 1998. Claims
In Vitro Salivary Protein Adsorption Profile on Titanium and Ceramic Surfaces and the Corresponding Putative Immunological Implications

Immune responses triggered by implant abutment surfaces contributed by surface-adsorbed proteins are critical in clinical implant integration. How material surface-adsorbed proteins relate to host immune responses remain unclear. This study aimed to profile and address the immunological roles of surface-adsorbed salivary proteins on conventional implant abutment materials. Standardized polished bocks (5 × 5 × 1 mm3) were prepared from titanium and feldspathic ceramic. Salivary acquired pellicle formed in vitro was examined by liquid chromatography-tandem mass spectrometry and gene ontology (GO) analysis to identify and characterize the adsorbed proteins. Out of 759 proteins identified from pooled saliva samples, 396 were found to be attached to the two materials tested—369 on titanium and 298 on ceramic, with 281 common to both. GO annotation of immune processes was undertaken to form a protein–protein interaction network, and 14 hub proteins (≥6 interaction partners) (coding genes: B2M, C3, CLU, DEFA1, HSP90AA1, HSP90AB1, LTF, PIGR, PSMA2, RAC1, RAP1A, S100A8, S100A9, and SLP1) were identified as the key proteins connecting multiple (6–9) immune processes. The results offered putative immunological prospects of implant abutment material surface-adsorbed salivary proteins, which could potentially underpin the dynamic nature of implant–mucosal/implant–microbial interactions.
Flax Biomass Conversion via Controlled Oxidation: Facile Tuning of Physicochemical Properties

The role of chemical modification of pristine linen fiber (LF) on its physicochemical and adsorption properties is reported in this contribution. The surface and textural properties of the pristine LF and its peroxyacetic acid- (PAF) and chlorite-treated (CF) fiber forms were characterized by several complementary methods: spectroscopy (SEM, TEM, FT-IR, and XPS), thermal analysis (DSC and TGA), gas/water adsorption isotherms, and zeta potential (ξ). The results obtained reveal that the surface charge and textural properties (surface area and pore structure) of the LF material was modified upon chemical treatment, as indicated by changes in the biomass composition, morphology, ξ-values, and water/dye uptake properties of the fiber samples. Particularly, the pristine LF sample displays preferential removal efficiency (ER) of methylene blue (MB) dye with ER ~3-fold greater (ER~62%) as compared to the modified materials (CF or PAF; ER~21%), due to the role of surface charge of pectins and lignins present in pristine LF. At higher MB concentration, the relative ER values for LF (~19%) relative to CF or PAF (~16%) reveal the greater role of micropore adsorption sites due to the contributing effect of the textural porosity observed for the modified flax biomass at these conditions. Similar trends occur for the adsorption of water in the liquid vs. vapour phases. The chemical treatment of LF alters the polarity/charge of the surface functional groups, and pore structure properties of the chemically treated fibers, according to the variable hydration properties. The surface and textural properties of LF are altered upon chemical modification, according to the variable adsorption properties with liquid water (l) vs. water vapor (g) due to the role of surface- vs. pore-sites. This study contributes to an understanding of the structure-adsorption properties for pristine and oxidized flax fiber biomass. The chemical conversion of such biomass yields biomaterials with tunable surface and textural properties, as evidenced by the unique adsorption properties observed for pristine LF and its modified forms (CF and PAF). This study addresses knowledge gaps in the field by contributing insight on the relationship between structure and adsorption properties of such LF biomass in its pristine and chemically modified forms.