Miracle-dz/UniFAR-FTUs huggingface dataset:
Toxicological, chemical and antibacterial evaluation of squill vinegar, a useful product in Persian Traditional Medicine

Background and objectives Squill [Drimia maritima (L.) Stearn] is an important medicinal plant that has been used for medicinal purposes such as cardiovascular diseases and asthma since ancient times. Bufadienolides are the main compounds of this plant and are responsible for some reported adverse effects. In order to reduce adverse effects, different methods like boiling with vinegar were applied by traditional practitioners. In the present study, the acute oral toxicity, cytotoxic effects, proscillaridin A content and antibacterial properties of methanol and vinegar extracts of squill white variety were compared for exploring the efficacy of traditional processing method.MethodsDifferent doses of extracts (1000-5000 mg/kg) were administered during oral gavage in rats to analyze the acute oral toxicity. Cytotoxicity against HT-29, Caco-2 and NIH3T3 cell lines and antibacterial activity (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli) were investigated using MTT assay and conventional agar dilution method, respectively. Proscillaridin A content was evaluated in the extracts (vinager and methanol) by a validated high performance liquid chromatography method.ResultsDuring the in vivo research no death or observed effect occurred in animals that received the extracts. Our results showed that all of the extracts exhibited no cytotoxic effects in experimented cell lines (IC50>1000 μg/mL). Proscillaridin A was only detected in the methanol extract and no significant antibacterial effect was detected in methanol extract.ConclusionAccording to results of the present study, processing squill with vinegar according to traditional experiences can reduce possible the side effects of bufadienolids.
THE RESTRICTED ISOMETRY PROPERTY AND ` Q-REGULARIZATION : PHASE TRANSITIONS FOR SPARSE APPROXIMATION

Consider a measurement matrix A of size n×N , with n < N , y a signal in RN , and b = Ay the observed measurement of the vector y. From knowledge of (b, A), compressed sensing seeks to recover the k-sparse x, k < n, which minimizes ‖b − Ax‖. Using various methods of analysis — convex polytopes, geometric functional analysis, and the restricted isometry property (RIP) — it has been proven that x can be reconstructed via `q-regularization (q ∈ (0, 1]) provided A satisfies conditions dictated by the method of analysis. This article focuses on the RIP approach and A with entries drawn i.i. d. from the Gaussian distribution N (0, 1/ √ n), developing more precise bounds on the restricted isometry constants, and using these bounds in an asymmetric RIP formulation to quantify the region of ( n N , k n ) in which RIP implies that `q-regularization will typically recover all k-sparse signals. Letting n N → δ and k n → ρ as n → ∞, the aforementioned recoverability region is characterized by all ρ < (1 − )ρRIP S (δ; q) for any > 0, where ρRIP S (δ; q) is a lower bound of the true phase transition below which ` q-regularization will typically recover all k-sparse signals. This phase transition framework, proposed in this context by Donoho (2005), is applied to compressed sensing results obtained by the analysis techniques of centro-symmetric polytope theory (Donoho), geometric functional analysis (Rudelson and Vershynin), and the RIP (Candès, Romberg and Tao; Foucart and Lai; Chartrand). Recasting the results from different methods of analysis into a common phase transition framework allows for the direct comparison of the efficacy of the respective results.
Use of Monoclonal Antibodies in Conditioning Regimen in Transplantation

Monoclonal antibodies (MoAbs) alone or in the combination of conventional therapies have been used in the treatment of many benign or malign diseases. In the transplanta‐ tion setting, Moabs have been generally applied as a part of conditioning regimen in the aims of the prevention of graft versus host disease and/or graft failure or treatment of un‐ derlying hematologic disease. The most frequent used moAbs for this purpose are rituxi‐ mab, alemtuzumab, Gemtuzumab Ozogamicin or radioimmunoconjugates. In this chapter, we discussed the role of moAbs use in the conditioning regimens of allogeneic or autologous stem cell transplantation.
Non fermenters are emerging from pyogenic lesions: a case series from burdwan medical college

Saprophytic Non-fermenting Gram negative bacilli have emerged as important healthcare associated pathogens.These organisms are ubiquitous in nature particularly in soil & water even found in hospital environment.This case series contains several cases of nonfermenters that were reported from Burdwan Medical College & Hospital within 15 days. The increasing multidrug resistance shown by these important pathogens leave us with fewer option to treat severe life threatening infections.
Cross-Sectional Study on Calf Health and Management Problems on Small Scale Dairy Farms of Sidama and Gedio Zones , Southern Ethiopia

A Cross-sectional study was conducted from October, 2010 to December, 2013 to assess the calf health and management problems and the associated risk factors in small scale dairy farms of Sidama and Gedio Zones. The study comprises 61 urbans, 46 peri-urban and 54 rural farms, from which 61 (37.7%) are intensive, 47 (29.0%) semi intensive and 54 (33.3) extensive farms. Data with regard to birth history, colostrum feeding management, vaccination practices and previous disease history of selected calves were collected with semi structured questionnaire and observational assessment; and microbiological identification and Flotation and Sedimentation techniques were part of the study methodology. Results indicate among the risk factors considered for analysis, only sex of farm owner, herd size and breed of calves were found to be significant with health problems of calves (P<0.05). Birth condition of 16.28 (n= 14) calves were assisted, out of which 13 (15.12%), were attended by non-professionals and 1 (1.16%) of the cases were attended by professional veterinary practitioners. 50.0% delivery problem was both maternal and calf caused, oversized fetus and delivery impotency were mentioned by farmers as a potential cause for dystocia. Majority of the respondent (92.6%) replied colostrum feeding and 7.4% not fed colostrum; general calf morbidity of 30.2% (n= 159), with zonal prevalence of Sidama zone (29.3%), Gedio zone (35.0%). High Prevalence of calf morbidity was seen in farms located in urban area 12.6% followed by rural farms 9.3% and urban farms 8.2%. Septicemia and Diarrhea 21 (43.7%) was found to be the most frequently observed disease syndrome followed by Internal parasite 15 (31.2%), external parasite 8 (16.7%), Coccidiosis 1 (2.08%), Hemoparasite 1 (2.08%) and mixed infection 2 (4.2%). 50.9% vaccinated their calves at least for one type of vaccine. The major internal parasites identified by floatation and sedimentation techniques were Strongyle spp. (32%), emeria (16%), neoasacris vitulorum (12.0%), mixed parasite strongyle spp. and eimeria (10%) and neoascaris vitulorum and Strongyle spp. (8%). From the isolated bacteria, E. coli (53.3%) was the higher prevalent and followed by proteus (10%), Citrobacter (8.3%), E. coli and Klebsiella mixed (8.3%). In conclusion, this research revealed that the proportion of calf morbidity that caused by bacteria was higher than internal and external parasites caused calf morbidity, E. coli and Strongyle spp. were the dominant bacteria and internal parasites respectively in the study dairy farms; high calf morbidity in rural than urban areas and the majority respondents had an awareness of colostrums effect on their calves. Yibrah Tekle1* and Tsega Berihe2
OCCURRENCE OF CLOSTRIDIUM PERFRINGENS IN FOOD CHAIN

The occurrence of Clostridium perfringens in particular links of food chain and their toxic potential was studied. Compound feeding stuffs, poultry, swine, and bovine faeces, food of animal origin, and human faeces were examined microbiologically. The isolated anaerobes were analysed for presence of toxin genes (cpa, cpb, cpb2, etx, iap, and cpe). The presence of C. perfringens on level higher than 1.0 x 10 1 cfu/g were detected in 68% of feed samples, 36% of poultry faeces, 92% of swine faeces, 67% of bovine faeces, 4% of food samples, and in 67% of human faeces. The detected levels of type A C. perfringens strains did not exceed the number of these strains physiologically present in the intestines of birds and mammals. Food and feed samples also revealed good microbiological quality. The identification of toxin type and subtype revealed domination of type A strains and among them the percentage of subtype β2 strains varied considerably. The second toxotype detected was toxotype E. There were no cpe-positive strains in the analysed food of animal origin.
Self-similarity of strongly stratified inviscid flows

It is well-known that strongly stratified flows are organized into a layered pancake structure in which motions are mostly horizontal but highly variable in the vertical direction. However, what determines the vertical scale of the motion remains an open question. In this paper, we propose a scaling law for this vertical scale Lv when no vertical lengthscales are imposed by initial or boundary conditions and when the fluid is strongly stratified, i.e., when the horizontal Froude number is small: Fh=U/NLh≪1, where U is the magnitude of the horizontal velocity, N the Brunt–Vaisala frequency and Lh the horizontal lengthscale. Specifically, we show that the vertical scale of the motion is Lv=U/N by demonstrating that the inviscid governing equations in the limit Fh→0, without any a priori assumption on the magnitude of Lv, are self-similar with respect to the variable zN/U, where z is the vertical coordinate. This self-similarity fully accounts for the layer characteristics observed in recent studies reportin.
Accelerating Lossless Compression with GPU

—With the increasing amount of data used for various purposes, maintaining the efﬁciency of storing and transmitting them are proving to be a challenge. Data compression brings forward a solution to this issue. We perform a lossless compression of data on Graphic Processor Units (GPU) for NVIDIAs CUDA Framework, using a parallelized Lempel-Ziv-Storer-Szymanski (LZSS) compression algorithm. Algorithms were implemented using PFAC library and KMP along with LZSS. Performance results were obtained for serial and parallel CPU implementations of the LZSS algorithm as well as CUDA implementations. The improved algorithms were also benchmarked with gzip and bzip2, which are popular compression programs. We achieved a speedup of 5x for the parallelized LZSS CPU implementation compared to the serial LZSS algorithm.
O CUSTO DO ENCARCERAMENTO NO BRASIL SOB A ÓTICA DA ANÁLISE ECONÔMICA DO DIREITO

O presente artigo elabora levantamento do custo do encarceramento no Brasil sob a otica da Analise Economica do Direito. Justifica-se a escolha do tema por se tratar de questao desconsiderada no mundo juridico-penal e penitenciario brasileiro, e tambem pouco explorada no meio academico e tratada de forma equivocada e exagerada nos meios de comunicacao de massa. O objetivo da pesquisa e mostrar que a analise economica do Direito e instrumento fundamental para determinar o custo do encarceramento em suas diferentes vertentes. Constatou-se que o calculo do custo da privacao da liberdade no Brasil incorre na omissao de aspectos relevantes que comprometem a veracidade das informacoes utilizadas, invariavelmente, em propostas de politicas publicas na area da seguranca. Para demonstrar essa discrepância, comparam-se dados colhidos em fontes variadas, com enfase a informacoes colhidas em instituicoes oficiais e analise critica da realizacao da justica por meio do encarceramento.
1 Mutations of the DNA repair endonuclease ERCC 4 / XPF cause Fanconi anemia

Genome Instability and DNA Repair Group, Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain. Centre for Biomedical Network Research on Rare Dise ases (CIBERER), Instituto de Salud Carlos III, Bell aterra, 08193, Barcelona, Spain. Department of Human Genetics, University of Wurzbur g, D-97074, Wurzburg, Germany. Department of Clinical Genetics, VU University Medi cal Center, 1081 BT, Amsterdam, The Netherlands. Department of Pharmacological Sciences and Chemistr y, S ony Brook University, 11794-3400, Stony Brook, New York, USA. Department of Genetics, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands Hematopoiesis and Gene Therapy Division, Centro de Inv stigaciones Energéticas, Medioambientales y Tec nológicas (CIEMAT), 28040, Madrid, Spain. Department of Bioinformatics. Sistemas Genómicos SL , 46980, Valencia, Spain. Human Genetics Group, Spanish National Cancer Cente r, CNIO, E-28029, Madrid, Spain.
Nuclear anapole moment interaction in BaF from relativistic coupled-cluster theory

We present high-accuracy relativistic coupled-cluster calculations of the P-odd interaction coefficient W-A describing the nuclear anapole moment effect on the molecular electronic structure. The molecule under study, BaF, is considered a promising candidate for the measurement of the nuclear anapole moment, and the preparation for the experiment is now underway [E. Altuntas et al., Phys. Rev. Lett. 120, 142501 (2018)]. The influence of various computational parameters (size of the basis set, treatment of relativistic effects, and treatment of electron correlation) on the calculated W-A coefficient is investigated and a recommended value of 147.7 Hz with an estimated uncertainty of 1.5% is proposed.
MR based electric properties imaging for hyperthermia treatment planning and MR safety purposes

Many randomized clinical studies have shown that the therapeutic effect of radiotherapy and chemotherapy is significantly enhanced when used in combination with hyperthermia (tumor heating in the range of 41-45 ℃). To generate spatially focussed heating in the deep seated tumors (e.g. cervical, bladder, prostate tumors), RF phased antenna-array systems are used. Prior to treatment, electromagnetic simulation is employed to compute the optimal antenna settings, a procedure known as Hyperthermia Treatment Planning. The electromagnetic field interactions between the system and the patient are governed by the electric tissue properties. Therefore, an accurate patient dielectric model is essential for optimal hyperthermia. This research was initiated to acquire electric tissue properties in living conditions (in vivo) by Magnetic Resonance Imaging (MRI) because the values reported in the literature show large variations for normal tissue. Furthermore, the tumor electric properties are scarcely reported in the literature. In this thesis electric tissue properties of 20 cervical cancer patients were acquired by an MR based method known as the Electric Properties Tomography (EPT). The results showed that in vivo values are higher than commonly used (Ch.3&4). The impact of the acquired electric properties on hyperthermia were investigated in five patient models, showing a significant impact in particular cases (Ch.5). Furthermore, a novel method is introduced in this thesis based on Contrast Source Inversion (CSI-EPT) and a great performance was shown for reconstruction of properties of small structures and at tissue boundaries (Ch.6). Finally, the potential of CSI-EPT was shown for MR safety purposes (Ch.7).
Measurement of the nonlinear Meissner effect in superconducting Nb films using a resonant microwave cavity: A probe of unconventional pairing symmetries

The National High Magnetic Field Laboratory, Florida State University,1800 E. Paul Dirac Drive, Tallahassee, Florida 32310, USA(Dated: published 11 January 2010 in Physical ReviewB RapidComm. 81, 020504(R) (2010))We report observation of the nonlinear Meissner eﬀect (NLME) in Nb ﬁlms by measuring theresonance frequency of a planar superconducting cavity as a function of the magnitude and theorientation of a parallel magnetic ﬁeld. Use of low power rf probing in ﬁlms thinner than the Londonpenetration depth, signiﬁcantly increases the ﬁeld for the vortex penetration onset and enablesNLME detection under true equilibrium conditions. The data agree very well with calculations basedon the Usadel equations. We propose to use NLME angular spectroscopy to probe unconventionalpairing symmetries in superconductors.
ATINER ' s Conference Paper Series MDT 2013-0746

In a few decades Mediterranean societies deeply transformed themselves as regards many demographic aspects. As in the northern rim but with remarkable delay, in the southern rim a lot of countries entered a new regime. This became evident in the second part of the last century. Demographic literature usually calls the passage from pre-modern to modern regime ‘demographic transition’. According to some scholars, in Europe and in some other developed countries outside Europe the development of the demographic transition has led to enter a further new regime known as ‘second demographic transition’. But accordance does not exist on a different and new demographic transformation and also the presence of a breakdown is disputed. Knowledge risen from our past and present research led us to argue about different demographic situations in southern Mediterranean countries. Our purpose here is to better address the theoretical issue of the demographic transitions for the countries of the southern rim of the Mediterranean discussing the adherence of theoretical models to empirical evidence. Moreover, problems concerning tempo effects and tempo distortions in period fertility indicators are considered to asses the real intensities of fertility and, consequently, the real state of demographic development.
Tawy, Gwenllian F. and Rowe, Philip J. and Riches, Philip E. (2016) Thermal damage done to bone by burring and sawing with and without irrigation in knee

3 Background: Heat from bone resecting tools used in knee surgery can induce thermal 4 osteonecrosis; potentially causing aseptic implant loosening. This study compared oscillating 5 saws to burrs in terms of temperature generation and histological damage. Use of irrigation 6 to reduce bone temperature was also investigated. 7 Methods: Temperatures were recorded during sawing and burring with/without irrigation 8 (uncooled/cooled). Histological analyses were then carried out. Differences between groups 9 were tested statistically (g = 0.05). 10 Results: On average, burring produced higher temperatures than sawing (p < 0.001). When 11 uncooled irrigation was used, bone temperatures were significantly lower in sawed bone 12 than in burred bone (p < 0.001). Irrigation lowered temperatures and thermal damage 13 depths, and increased osteocyte viability (p < 0.001). 14 Conclusion: These results suggest that irrigating bone during resection could prevent 15 osteonecrosis onset. 16 17
HYPOLIPIDEMIC POTENTIAL OF METHANOLIC EXTRACT OF GRACILARIA CORTICATA ON STREPTOZOTOCIN-INDUCED DIABETIC RATS

ABSTRACT Objectives: Diabetes mellitus is associated with profound alterations in the levels of plasma lipids and the lipoprotein profile. Herbs and herbal drug preparations find wide use in alleviating the complications of uncontrolled diabetes owing to their low cost and lesser side effects. This study was aimed at establishing the hypolipidemic effect of methanolic extract of sea weed Gracilaria corticata on streptozotocin (STZ)-induced diabetic rats. Methods: STZ-induced Wistar male albino rats were administered with methanolic extract of Gracilaria corticata (MGC) at a dosage of 100 mg/kg BW/day per orally for 45 days. Glibenclamide (600 μg/kg BW/day) administered rats served as standard drug control. Animals were sacrificed on 46th day, biochemical parameters associated with lipid metabolism were analyzed in blood and tissue samples, statistical significance determined. Results: Elevated levels of total cholesterol, triglycerides, and free fatty acids were observed in the plasma and tissues of diabetic rats as compared to MGC and glibenclamide treated groups. The diabetic rats also had elevated levels of low-density lipoprotein (LDL-C) and very low-density lipoprotein (VLDL-C) and decreased levels of high-density lipoprotein (HDL-C) while the MGC and glibenclamide treated rats showed near normal levels of these indices. Conclusion: This study establishes the hypolipidemic potential of MGC in STZ-induced diabetic rats. Keywords: Gracilaria corticata, Diabetes mellitus, Hypolipidemic, Streptozotocin.
PROPHYLACTIC EFFICACY OF BACOPA MONNIERI ON DECABROMODIPHENYL ETHER (PBDE-209)-INDUCED ALTERATIONS IN OXIDATIVE STATUS AND SPATIAL MEMORY IN MICE

Bacopa monnieri (BM) is extensively used as a nerve tonic in traditional medicine systems, originated from India and neighbouring countries. BM possesses antioxidative and memory enhancing properties. The present study has been designed to investigate the neuroprotective role of Bacopa monnieri against PBDE-209-induced alterations in spatial memory and oxidative status in the frontal cortex and hippocampus of mice. The mice were orally administered with PBDE-209 at the dose of 20 mg/kg bw from PND 3-10. BM at the doses of 40, 80 or 120 mg/kg body weight (bw) were co-administered with 20 mg/kg of PBDE-209 from PND 3-10 . The spatial memory of young mice were evaluated by Morris water maze (MWM) and 8-armed radial maze (RAM) . We also tested cellular oxidants e.g. MDA (malondialdehyde) , protein carbonyl (PC) and antioxidant enzymes e.g. superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) in the frontal cortex (FC) and hippocampus (Hc) of mice at neonate (PND 11) and young age (PND 60). Supplementation with BM significantly restored the levels of MDA and protein carbonyls in FC and Hc, which were elevated significantly after PBDE-209 exposure. PBDE-209-induced decrease in the activities of antioxidant enzymes recovered significantly following supplementation with BM. Further, BM-supplementation resulted in significant improvement in the working and reference memory of PBDE-209 exposed mice. The findings, therefore, suggest the neuroprotective efficacy of BM against PBDE-209-induced impairments in spatial memory and oxidative status.
A model of customer e-loyalty in the online banking

With the rapid growth of online banking, it has been reinforced that companies need to build and maintain loyal customers. This study models e-loyalty as the endogenous variable that includes three exogenous variables (website quality, corporate image and perceived social presence) and two mediating variables (satisfaction and trust). The model was empirically tested using data collected from an online survey of Internet forums based in Indonesia. Using structural equation modeling, the results of statistical analysis show that the model is an adequate fit to the data. All the causal relationships in this model were found to be significant. We discuss some interesting results and provide several implications for those banks which want to enhance loyalty of e-banking customers.
Studying Cell Signal Transduction with Biomimetic Point Mutations

Post-translational modification (PTM), the chemical modification of a protein after its translation, represents an evolutionarily conserved mechanism of regulation of protein function. (Deribe et al., 2010) Through modulation of conformational change, enzymatic activity or interaction with other proteins, it often provides a transient switch between various intracellular signals to orchestrate an integrated response of the cell to environmental cues.