Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel, Combined Approach to Semitic Word-Formation

This paper examines the way in which constraints on root and template size in Semitic have been formalized in the literature since McCarthy (1979). It identifies three approaches: McCarthy's double-tier approach, where the sizes of both template and root are arbitrary; Ussishkin's (1999) and Bat El's (2003) strictly-vocalic approach, where the template is reduced to its vowels; and the less known root-first approach of Goldenberg (1994), where vocalization is determined by the number of root consonants. The paper points to the problems of each approach and proposes a new, combined approach which solves these problems, by assuming that the template applies to the root, not to the verb. This approach is shown to be successful in the analysis of three test cases from Modern Hebrew: 1) reduplicative verbs; 2) the range of forms based on biradicals; and 3) the exceptionality of the Qal participle.
α1 adrenergic receptor agonist, phenylephrine, actively contracts early rat rib fracture callus ex vivo

Early, soft fracture callus that links fracture ends together is smooth muscle‐like in nature. We aimed to determine if early fracture callus could be induced to contract and relax ex vivo by similar pathways to smooth muscle, that is, contraction via α1 adrenergic receptor (α1AR) activation with phenylephrine (PE) and relaxation via β2 adrenergic receptor (β2AR) stimulation with terbutaline. A sensitive force transducer quantified 7 day rat rib fracture callus responses in modified Krebs–Henseliet (KH) solutions. Unfractured ribs along with 7, 14, and 21 day fracture calluses were analyzed for both α1AR and β2AR gene expression using qPCR, whilst 7 day fracture callus was examined via immunohistochemistry for both α1AR and β2AR‐ immunoreactivity. In 7 day callus, PE (10−6 M) significantly induced an increase in force that was greater than passive force generated in calcium‐free KH (n = 8, mean 51% increase, 95% CI: 26–76%). PE‐induced contractions in calluses were attenuated by the α1AR antagonist, prazosin (10−6 M; n = 7, mean 5% increase, 95% CI: 2–11%). Terbutaline did not relax callus. Gene expression of α1ARs was constant throughout fracture healing; however, β2AR expression was down‐regulated at 7 days compared to unfractured rib (p < 0.01). Furthermore, osteoprogenitor cells of early fibrous callus displayed considerable α1AR‐like immunoreactivity but not β2AR‐like immunoreactivity. Here, we demonstrate for the first time that early fracture callus can be pharmacologically induced to contract. We propose that increased concentrations of α1AR agonists such as noradrenaline may tonically contract callus in vivo to promote osteogenesis. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:740–745, 2011
Public policy statement on the rights and responsibilities of healthcare professionals in the use of opioids for the treatment of pain.

Healthcare professional (HCP) concerns regarding the potential for harm to patients, as well as possible legal, regulatory, licensing or other third party sanctions related to the prescription of opioids, contribute significantly to the mistreatment of pain. HCPs are obligated to act in the best interest of their patients. This action may include the addition of opioid medication to the treatment plan of patients whose symptoms include pain. Though many types of pain are best addressed by non-opioid interventions, opioids are often indicated as a component of effective pain treatment. It is sometimes a difficult medical judgment as to whether opioid therapy is indicated in patients complaining of pain because objective signs are not always present.
EGCG attenuates AMPA-induced intracellular calcium increase in hippocampal neurons.

We have investigated the protective effect of (-)-epigallocatechin gallate (EGCG) on alpha-amino-3-hydroxy-5-methyl-4-isoxazolo propionate (AMPA)-induced toxicity in cultured rat hippocampal neurons. Treatment of 24 h AMPA (10 microM) reduced the neuronal viability in both survival neuron counting and MTT reduction assay compared with control, with increase in cellular concentrations of hydrogen peroxide and malondialdehyde. These responses to AMPA were significantly blocked by co-treatments with EGCG (10 microM), which effect was very similar to the protective ability of a known antioxidant catalase (2000 U/ml). AMPA (50 microM) elicited the increase in intracellular calcium concentration ([Ca(2+)]i) on which EGCG significantly attenuated both peak amplitude and sustained nature of that [Ca(2+)]i increase in a dose-dependent manner. These data suggest that EGCG has a neuroprotective effect against AMPA through inhibition of AMPA-induced [Ca(2+)]i increase and consequent attenuation of reactive oxygen species production and lipid peroxidation as an antioxidant and a radical scavenger.
Phase Corrected ${H}$ -Plane Horn Antenna in Gap SIW Technology

This communication introduces a modified substrate integrated waveguide (SIW), the gap SIW, and deduces an approximate closed-form expression for calculating its effective width, taking into account the fringing and coupling fields around the gap. As an immediate application, this new structure is used to correct the phase distribution of an H-plane SIW horn antenna. The achieved quasi-uniform distribution results in a greatly enhanced antenna gain without deteriorating the bandwidth. To further improve both radiation and impedance matching, printed tapered-ladder transitions are introduced in front of the horn aperture. Software optimization confirms the possibility of simultaneously achieving an excellent phase correction (and hence increased gain) and a good impedance matching in a probe-excited horn antenna model. Measurements on a homemade prototype validate the design strategy. The final compact Ka-band planar horn antenna achieves an enhanced gain of 10.3 dBi at 34 GHz, with an impedance bandwidth of 20%.
[Clinical analysis and follow-up study of Epstein-Barr virus associated-hemophagocytic lymphohistiocytosis in childhood].

OBJECTIVE To identify the clinical characteristics of and to explore the prognostic factors influencing mortality in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH). METHOD A retrospective study was conducted on 62 pediatric patients with EBV-HLH who were admitted to our hospital between 2003 and 2008. All their medical records were reviewed and analyzed. For each patient, demographic, clinical and laboratory data, genetic findings and outcome information were collected. The patients were divided into two groups: deceased or survived based on the follow-up results. Comparative analysis of the data was done by using independent-samples t test and Logistic multiple and univariate regression. RESULT (1) Among the 62 EBV-HLH patients, 36 were male and 26 were female. The age of onset ranged from 2 months to 14 years and most of the patients were between 1 and 3 years of age. EBV-HLH occurred mainly in the setting of reactivation (61.3%). (2) All patients exhibited persistent or intermittent fever and cytopenia >/= 2 cell lines. Most of the patients presented with hepatomegaly (83.9%), splenomegaly (72.6%) and lymphadenopathy (69.4%). The main laboratory features showed an elevation of serum ferritin and aminotransferase levels. A reduction in serum albumin was observed and exhibited coagulopathy with hypofibrinogenemia and hypertriglyceridemia in most of the patients. Forty-eight of patients had hemophagocytosis in bone marrow at diagnosis of EBV-HLH. The serum EBV DNA level in 14 of 31 patients with EBV-HLH was in the range of 5.12 x 10(2) - 7.69 x 10(7) copies/ml with a mean value of 10(3.9) copies/ml. (3) Three heterozygous mutations in coding region were found, which resulted in amino acid change (C102F, S108N and T450M) in 3 patients. One patient had compound heterozygous mutations (S108N and T450M) in the PRF1 gene as the background defect and documented familial HLH type 2 (FHL2). (4) During the observational period, 35 of 57 patients (61.4%) died 3 months to 3 years after the onset, while 21 of whom died despite aggressive polychemotherapy, 15 of whom died within 2 months after hospitalization. The deceased patients were more likely to have lower albumin level and more prolonged activated partial thromboplastin time than the survived patients (P < 0.05 for all comparisons). Multivariate Logistic regression analysis revealed that duration of illness >/= 1 month, non-chemotherapy, albumin level < / = 25 microg/L and internal organs hemorrhage were related with the prognosis significantly (P < 0.05 for all comparisons). CONCLUSION This study revealed that EBV-HLH infection in pediatric patients had severe clinical courses and prognosis was poor and the majority of cases underwent EBV reactivation. The early diagnosis, prompt and proper chemotherapy can improve the survival rate. The duration of illness >/= 1 month, non-chemotherapy, decreases in albumin and internal organs hemorrhage were the risk factors related to mortality in children with EBV-HLH.
A unified computational framework for modeling genome-wide nucleosome landscape

Nucleosomes form the fundamental building blocks of eukaryotic chromatin, and previous attempts to understand the principles governing their genome-wide distribution have spurred much interest and debate in biology. In particular, the precise role of DNA sequence in shaping local chromatin structure has been controversial. This paper rigorously quantifies the contribution of hitherto-debated sequence features—including G+C content, 10.5 bp periodicity, and poly(dA:dT) tracts—to three distinct aspects of genome-wide nucleosome landscape: occupancy, translational positioning and rotational positioning. Our computational framework simultaneously learns nucleosome number and nucleosome-positioning energy from genome-wide nucleosome maps. In contrast to other previous studies, our model can predict both in vitro and in vivo nucleosome maps in Saccharomyces cerevisiae. We find that although G+C content is the primary determinant of MNase-derived nucleosome occupancy, MNase digestion biases may substantially influence this GC dependence. By contrast, poly(dA:dT) tracts are seen to deter nucleosome formation, regardless of the experimental method used. We further show that the 10.5 bp nucleotide periodicity facilitates rotational but not translational positioning. Applying our method to in vivo nucleosome maps demonstrates that, for a subset of genes, the regularly-spaced nucleosome arrays observed around transcription start sites can be partially recapitulated by DNA sequence alone. Finally, in vivo nucleosome occupancy derived from MNase-seq experiments around transcription termination sites can be mostly explained by the genomic sequence. Implications of these results and potential extensions of the proposed computational framework are discussed.
Interaction Between Hypertension and Diabetes Mellitus in the Pathogenesis of Sensorineural Hearing Loss

The purpose of this study is to support the hypothesis that diabetic end‐organ damage of the cochlea is augmented in the setting of hypertension. A historical perspective reviewing the effects of diabetes and hypertension as causative factors in the development of sensorineural hearing loss, as well as the basic epidemiology and pathophysiology of the renal and vascular effects of diabetes and hypertension, is presented. The results of audiologic findings in insulin‐dependent diabetic patients, both normotensive and hypertensive, were analyzed and correlated with the results of animal studies to support the hypothesis that sensorineural hearing loss in patients and cochlear hair cell loss in animal studies result from the effects of hypertension in conjunction with insulin‐dependent diabetes mellitus.
Detection of mixed Mycoplasma species

Immunofluorescence can be used to demonstrate mixed species within a mycoplasma culture; however, it may fail to do so if one species is present in very low numbers. To enhance the detection of minor components in such mixtures, a technique was developed, based on the growth inhibition test, whereby the growth of the major component in a mixed culture was inhibited, thus permitting the minor component to emerge. The method was applied to 67 field isolates from chickens and turkeys, which had been examined by immunofluorescence and were thought to contain only one mycoplasma species. Of these, 26 cultures were found to be mixtures, and in some instances the pathogenic species Mycoplasma gallisepticum and M. meleagridis were revealed.
Increasing cataract surgery to meet Vision 2020 targets; experience from two rural programmes in east Africa

Background: The numbers of cataract surgeries done in sub-Saharan Africa fall short of Vision 2020 targets. Over a few years, two programmes in rural east Africa both achieved significant increases in the number of cataract surgeries they provide, resulting in cataract surgical rates of 1583 for Kwale District in Kenya and 1165 for Kilimanjaro Region in Tanzania. Key components of success in these two programmes are described. Methods: Data were collected on standard indicators and key personnel interviewed to describe the results and compare the methods employed to increase cataract surgical rates by the Kwale District Eye Centre programme and the Kilimanjaro regional Vision 2020 programme. Results: Key components of success shared by the programmes included: (1) programmes in the community and at the hospital are closely linked so that they increase capacity together; (2) community programmes are “patient friendly,” providing service in one stop; (3) the examination team includes eye workers with enough skill to provide treatment and decide who is operable so that patients are not transported needlessly or sent through a lengthy referral chain; (4) sites for visits in the community are selected according to population distribution and they are visited according to a regular schedule. Conclusion: The development of “bridging strategies” that create a strong link between hospitals providing clinical service and communities needing these services is a key component to realising Vision 2020 goals in sub-Saharan Africa.
Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele.

OBJECTIVE To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon3 allele. METHODS Participants were healthy, cognitively intact, right-handed adults, age 19 to 80, who completed genotyping, neuropsychological testing, and MRI. Forty-nine participants had the epsilon3/epsilon3 genotype and 27 had the epsilon3/epsilon4 genotype. Gray matter data were analyzed using the general linear model as implemented in the Statistical Parametric Mapping package, adjusting for age and sex. RESULTS The epsilon3/epsilon4 participants showed lower gray matter density than the epsilon3/epsilon3 participants in right medial temporal and bilateral frontotemporal regions as well as other areas. There were no regions in which epsilon3/epsilon4 participants showed higher gray matter density than epsilon3/epsilon3 participants. CONCLUSIONS Regionally reduced gray matter density is detectable in cognitively intact adults with a single copy of the APOE epsilon4 allele.
Fusion Methods for Land Surface Emissivity and Temperature Retrieval of the Landsat Data Continuity Mission Data

In this paper, a new approach based on two fusion schemes is proposed to overcome the uncertainties in land surface emissivity (LSE) estimation and, consequently, land surface temperature (LST) retrieval. The fusion schemes are called image-based weighted methods and knowledge-based weighted methods, in which each of them includes two LSE estimation methods. The effectiveness of the two proposed fusion schemes is empirically tested over two scenes of Landsat-8 (known as Landsat Data Continuity Mission) data sets, and the obtained LSEs by individual and proposed methods were compared to the LSE product of Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) by image-based and class-based cross-comparison. In both scenes, the adjusted normalized emissivity method (ANEM) and NDVI-based emissivity method (NBEM) provide appropriate results among five individual methods. In contrast, weighted to median (WMED) achieves superior results among the proposed fusion methods for both scenes. In addition, the root-mean-square error (rmse) values of LSE obtained by ANEM and WMED are 1.48% and 0.87%, which lead to 1.25 K and 0.73 K errors in the LST retrieval by the single-channel algorithm in the first scene, respectively. For the second scene, the error values of NBEM and WMED are 1.10% and 0.52%, which lead to 0.93 K and 0.44 K errors in the LST, respectively. Moreover, the error ranges and rmse of cross-comparison for the obtained LSE in the proposed methods were remarkably decreased. Also, in this research, for LST cross-comparison, an alternative scaling method based on LST products of the Moderate Resolution Imaging Spectroradiometer was proposed. The LST validation results demonstrated that the proposed methods provide better estimates in terms of three accuracy measures in both examined data sets.
Characterization of a Streptococcus suis tet(O/W/32/O)-Carrying Element Transferable to Major Streptococcal Pathogens

ABSTRACT Mosaic tetracycline resistance determinants are a recently discovered class of hybrids of ribosomal protection tet genes. They may show different patterns of mosaicism, but their final size has remained unaltered. Initially thought to be confined to a small group of anaerobic bacteria, mosaic tet genes were then found to be widespread. In the genus Streptococcus, a mosaic tet gene [tet(O/W/32/O)] was first discovered in Streptococcus suis, an emerging drug-resistant pig and human pathogen. In this study, we report the molecular characterization of a tet(O/W/32/O) gene-carrying mobile element from an S. suis isolate. tet(O/W/32/O) was detected, in tandem with tet(40), in a circular 14,741-bp genetic element (39.1% G+C; 17 open reading frames [ORFs] identified). The novel element, which we designated 15K, also carried the macrolide resistance determinant erm(B) and an aminoglycoside resistance four-gene cluster including aadE (streptomycin) and aphA (kanamycin). 15K appeared to be an unstable genetic element that, in the absence of recombinases, is capable of undergoing spontaneous excision under standard growth conditions. In the integrated form, 15K was found inside a 54,879-bp integrative and conjugative element (ICE) (50.5% G+C; 55 ORFs), which we designated ICESsu32457. An ∼1.3-kb segment that apparently served as the att site for excision of the unstable 15K element was identified. The novel ICE was transferable at high frequency to recipients from pathogenic Streptococcus species (S. suis, Streptococcus pyogenes, Streptococcus pneumoniae, and Streptococcus agalactiae), suggesting that the multiresistance 15K element can successfully spread within streptococcal populations.
A Cantilever Vibrational Generator Based on an Fe–Co Beam

Typical vibrational harvesters using a high-permeability beam in a cantilever configuration exploit the field generated by a couple of counter-polarized permanent magnets facing the vibrating strip at the free end. Such a canonical position of the magnets does not permit one, however, to highlight the importance of the bias field pattern. A proof of concept archetype is realized in this paper, by which the influence of the magnetization profile along the length of the vibrating ferromagnetic beam is put in evidence. It demonstrates, in particular, that significant variations, even by a factor of three, of the output power can be obtained by a modification of the magnets arrangement. We discussed in this paper the behavior of a cantilever-based generator, where an Fe–Co high-permeability beam is made to vibrate inside an inhomogeneous magnetic field generated by permanent magnets, whose arrangement can modified in order to vary the magnetization profile along the vibrating laminae. The effects of such a profile are measured and analyzed by means of a simple 2-D numerical model, showing that the generated power can be enhanced by conveniently acting on the magnets configuration. The measurements show that, with a host acceleration of <inline-formula> <tex-math notation="LaTeX">$5g$ </tex-math></inline-formula> rms (<inline-formula> <tex-math notation="LaTeX">$g = 9.81$ </tex-math></inline-formula> m/<inline-formula> <tex-math notation="LaTeX">$\text{s}^{2}$ </tex-math></inline-formula>), a 6.72 mW time average output power is obtained for operating frequencies around 60 Hz.
Familial mental retardation due to a cryptic subtelomeric translocation -del 14qter and dup 9qter (the Anyon phenotype)

An example of familial mental retardation is described in which there is a distinctive phenotype. It consists of IQ in the 30–50 range, microcephaly, short stature, narrow skull, prominent ears and nose and a cryptic subtelomeric translocation resulting in del 14qter and dup 9qter. Variable features include congenital heart disease, peripheral neuropathy and epilepsy. The phenotype was described in 1965 by Anyon.
Análisis didáctico de procesos de estudio matemático basado en el enfoque ontosemiótico

Entre las tareas principales del profesor se encuentran el dise? o e implementaci? n de procesos de estudio y la valoraci? n de la propia pr? ctica docente con la fi nalidad de favorecer el aprendizaje de los estudiantes. En este trabajo utilizamos algunas nociones te? ricas para defi nir cinco niveles de an? lisis de los procesos de ense? anza y aprendizaje de las matem? ticas, que pueden ayudar a refl exionar a los profesores de matem? ticas sobre su pr? ctica docente. La introducci? n de estos niveles abre tambi? n nuevas perspectivas de investigaci? n en did? ctica de las matem? ticas. Las nociones utilizadas est? n basadas en el enfoque te? rico denominado ? ontosemi? tico? (EOS) donde el conocimiento matem? tico se modeliza teniendo en cuenta las dimensiones epist? mica, cognitiva e instruccional de la actividad matem? tica. Asimismo, se tienen en cuenta las dimensiones normativa y axiol? gica, las cuales son abordadas usando los tipos de objetos, procesos y signifi cados propuestos en el enfoque ontosemi? tico. Las herramientas te? ricas que describimos son aplicadas al an? lisis de una experiencia de ense? anza de nociones estad? sticas elementales.