Miracle-dz/UniFAR-FTUs huggingface dataset:
Blocks and Chains: Introduction to Bitcoin, Cryptocurrencies, and Their Consensus Mechanisms

Abstract The new field of cryptographic currencies and consensus ledgers, commonly referred to as blockchains, is receiving increasing interest from various different communities. These communities are very diverse and amongst others include: technical enthusiasts, activist groups, researchers from various disciplines, start ups, large enterprises, public authorities, banks, financial regulators, business men, investors, and also criminals. The scientific community adapted relatively slowly to this emerging and fast-moving field of cryptographic currencies and consensus ledgers. This was one reason that, for quite a while, the only resources available have been the Bitcoin source code, blog and forum posts, mailing lists, and other online publications. Also the original Bitcoin paper which initiated the hype was published online without any prior peer review. Following the original publication spirit of the Bitcoin paper, a lot of innovation in this field has repeatedly come from the community itself in t.
epositioning chloroquine and metformin to eliminate cancer stem cell traits in re-malignant lesions

Ideal oncology drugs would be curative after a short treatment course if they could eliminate epitheliumoriginated carcinomas at their non-invasive, pre-malignant stages. Such ideal molecules, which are expected to molecularly abrogate all the instrumental mechanisms acquired by migrating cancer stem cells (CSCs) to by-pass tumour suppressor barriers, might already exist. We here illustrate how system biology strategies for repositioning existing FDA-approved drugs may accelerate our therapeutic capacity to eliminate CSC traits in pre-invasive intraepithelial neoplasias. First, we describe a signalling network signature that overrides bioenergetics stressand oncogene-induced senescence (OIS) phenomena in CIS
Facial Image Processing

In the described embodiment, methods and systems for processing facial image data for use in animation are described. In one embodiment, a system is provided that illuminates a face with illumination that is sufficient to enable the simultaneous capture of both structure data, e.g. a range or depth map, and reflectance properties, e.g. the diffuse reflectance of a subject's face. This captured information can then be used for various facial animation operations, among which are included expression recognition and expression transformation.
RTSVC: Real‐time system for visual control of robots

This article presents an image processing system that can work in hard real‐time. Compared with systems that use the traditional multiprocessor architecture approach, this computer system takes advantage on recent technological advances and it is designed to work with a single processor PC under RTLinux. Its programming environment is similar to C programming language and it offers a friendly graphical user interface. The performance of the system is illustrated by means of experiments applied to visual guidance of mobile robots via velocity fields using a fixed high‐speed camera. The experiments were carried out with a strict sampling frequency of 100 Hz. © 2008 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 18, 251–256, 2008; Published online in Wiley InterScience (www.interscience.wiley.com).
Data-driven Morphology and Sociolinguistics for Early Modern Dutch

The advent of Early Modern Dutch (starting ∼1550) marked significant developments in language use in the Netherlands. Examples include the loss of the case marking system, the loss of negative particles and the introduction of new vocabulary. These developments typically lead to a lot of variation both within and between language users. Linguistics research aims to characterize and account for such variation patterns. Due to sparseness of digital resources and tools, research is still dependent on traditional, qualitative analysis. This paper describes an ongoing effort to increase the amount of tools and resources, exploring two different routes: (i) modernization of historical language and (ii) adding linguistic and sociolinguistic annotations to historical language directly. This paper discusses and compares the experimental setup, and preliminary results of these two routes and provides an outlook on the envisioned linguistic and sociolinguistic research approach.
Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence.

OBJECTIVE The purpose of this review was to examine the literature assessing the relationship between prenatal exposure to nicotine, alcohol, caffeine, and psychosocial stress during pregnancy to the risk of developing behavioral problems related to attention deficit hyperactivity disorder (ADHD) in childhood. METHOD PubMed, MEDLINE, EMBASE, and PsycINFO were searched systematically. Studies using DSM diagnostic criteria and other validated diagnostic or screening instruments for ADHD and those examining ADHD symptoms were included. A narrative approach was used because the studies differed too much in methods and data sources to permit a quantitative meta-analysis. RESULTS Twenty-four studies on nicotine (tobacco smoking), nine on alcohol, one on caffeine, and five on psychosocial stress were identified. All were published between 1973 and 2002. In spite of inconsistencies, the studies on nicotine indicated a greater risk of ADHD-related disorders among children whose mothers smoked during pregnancy. Contradictory findings were reported in the alcohol studies, and no conclusion could be reached on the basis of the caffeine study. Results from studies on psychological stress during pregnancy were inconsistent but indicated a possible modest contribution to ADHD symptoms in the offspring. Many studies suffered from methodological shortcomings, such as recall bias, crude or inaccurate exposure assessments, low statistical power, and lack of or insufficient control of confounders. A general lack of information on familial psychopathology also limited the interpretations. CONCLUSIONS Exposure to tobacco smoke in utero is suspected to be associated with ADHD and ADHD symptoms in children. Other maternal lifestyle factors during pregnancy may also be associated with these disorders. Further studies are needed to reach conclusions.
At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

The putative role of neutrophils in host defense against pathogens is a well‐recognized aspect of neutrophil function. The discovery of neutrophil extracellular traps has expanded the known range of neutrophil defense mechanisms and catalyzed a discipline of research focused upon ways in which neutrophils can shape the immunologic landscape of certain autoimmune diseases, including systemic lupus erythematosus. Enhanced neutrophil extracellular trap formation and impaired neutrophil extracellular trap clearance may contribute to immunogenicity in systemic lupus erythematosus and other autoimmune diseases by promoting the externalization of modified autoantigens, inducing synthesis of type I IFNs, stimulating the inflammasome, and activating both the classic and alternative pathways of the complement system. Vasculopathy is a central feature of many autoimmune diseases, and neutrophil extracellular traps may contribute directly to endothelial cell dysfunction, atherosclerotic plaque burden, and thrombosis. The elucidation of the subcellular events of neutrophil extracellular trap formation may generate novel, therapeutic strategies that target the innate immune system in autoimmune and vascular diseases.
Avaliação de Inseticidas Neonicotinóides para o Controle da Mariposa-Oriental Grapholita molesta (Busck) (Lepidoptera: Tortricidae) em Laboratório e Pomar Comercial de Maçã com Infestações Artificiais

A mariposa oriental, Grapholita molesta (Busck) (Lepidoptera: Tortricidae), e uma das principais pragas da cultura da macieira no Brasil. O controle do inseto tem sido realizado basicamente com inseticidas de alta toxicidade e nao seletivos aos inimigos naturais. Neste trabalho foi avaliado o efeito dos neonicotinoides acetamiprida (Mospilan, 20 e 40 g/100 L) e clotianidina (Focus PM, 10 e 20 g/100 L) comparados com o fosmete (Imidan 500 PM, 200 g /100 L) para o controle da G. molesta em laboratorio e pomar comercial utilizando infestacao artificial. Em laboratorio, posturas e frutos foram tratadas com os inseticidas e, em pomar comercial, as macas foram infestadas artificialmente apos a aplicacao dos produtos. Acetamiprida e clotianidina nas maiores doses reduziram a eclosao de lagartas em 99,7 e 79,7%, respectivamente enquanto que o fosmete nao apresentou efeito ovicida (12,4% de reducao). Na testemunha (agua) foi observada uma eclosao de lagartas de 96,6%. Os inseticidas acetamiprida e clotianidina proporcionaram uma mortalidade de lagartas de G. molesta em laboratorio apos 96 h entre 83,3 e 97,6 % equivalente ao fosmete (95,2%). Em pomar comercial, a mortalidade de lagartas avaliada nove dias apos a infestacao foi entre 76,9 e 88,4% indicando a viabilidade da metodologia para avaliar o efeito de inseticidas no controle do inseto. Os inseticidas neonicotinoides acetamiprida e clotianidina apresentam-se como alternativas ao emprego dos orgnofosforados para o controle da mariposa oriental na cultura da macieira.
Treatment of indolent lymphoma with fludarabine/mitoxantrone combination: a phase II trial

In an effort to reduce the risk of opportunistic infections, 25 patients with advanced indolent lymphoma (age range: 30–77 years) were treated, using a combination of fludarabine and mitoxantrone, without corticosteroids. Fludarabine was given at 25 mg/m2 for three daily doses, and mitoxantrone at 10 mg/m2. Cycles were repeated every four weeks for up to maximum response, and for no more than six months. Eight patients had follicular lymphoma, and 11 had CLL/SLL. Objective response was observed in 11 of 12 previously untreated patients, including five complete remissions, and in 10 of 13 previously treated patients, including three complete remissions. Only two relapsed patients failed to respond, whereas two patients were not evaluable. Hence, the overall response rate based on the intention‐to‐treat analysis was 84 per cent (95 per cent CI: 70–98 per cent). The median survival has not been reached after a 22‐month follow‐up. Median time to progression was 15 months. One patient on corticosteroids developed pneumocystis carinii pneumonia, and an elderly patient succumbed to neutropenic sepsis. Apart from granulocytopenia, the treatment was well tolerated. Omission of corticosteroids reduces the risk of opportunistic infections, while the activity of the combination against indolent lymphoma and CLL is maintained. Copyright © 1998 John Wiley & Sons, Ltd.
A SIMD Approach to Thread Matching for Interleaved Multithreading

Interleaved multithreading processors offer improved performance and power efficiency in a multithreading environment compared to standard CPUs by allowing multiple threads to share a single processing pipeline. However, resource contention is a natural result of such a system and can determine how well the overall thread group performs on the processor. Selecting threads which perform well together has proven to be a difficult problem to solve because it is computationally intensive and grows rapidly in complexity with the number of threads in a system. We propose a vector algorithm for this task which is able to significantly outperform a scalar implementation and which shows improved scaling characteristics.
Parainfluenza virus type 3 outbreak in a neonatal intensive care unit

Parainfluenza virus (PIV) is a respiratory pathogen in young children and is second only to the respiratory syncytial virus (RSV) as a cause of lower respiratory tract infection. PIV type 3 (PIV3) is the most severe. Herein we describe an outbreak of PIV3 in three infants in a neonatal intensive care unit. They were diagnosed on virus culture from pharyngeal swabs. We prevented the spread of the virus using standard infection control procedures and isolation of the symptomatic infants. One infant had severe chronic lung disease and was complicated with recurrent wheezing for a long time. Because RSV and PIV have many structural, pathogenic, epidemiologic, and clinical similarities, we speculate that PIV infection causes recurrent wheezing, as observed with RSV infection. Therefore, physicians must consider recurrent wheezing at the time of treatment of PIV infection early in life.
Increased responsiveness to dietary lysine deficiency of pectoralis major muscle protein turnover in broilers selected on breast development.

It has been previously established that growth and carcass qualities of chicks are modified by genotype and dietary amino acid supply. In this study, we evaluated the effects of lysine deficiency and genetic selection on muscle protein metabolism. Chicks originating from an experimental line selected for breast development (QL) and its control line (CL) were provided ad libitum access to isoenergetic diets containing 20% crude protein but differing in their lysine content (0.75 or 1.01%). Protein fractional synthesis rates (FSR) were measured in vivo in the pectoralis major and sartorius muscles of 3-wk-old chickens (flooding dose of [3H]phenylalanine). Fractional breakdown rates (FBR) were estimated as the difference between synthesis and deposition. Lysine deficiency reduced (P < 0.001) growth performance and muscle weights and increased (P < 0.05) muscle FSR, capacity for protein synthesis (muscle RNA:Protein, Cs) and FBR. Although QL birds grew faster and had heavier pectoralis major muscles than CL birds (P < 0.05), there was no line difference in sartorius weight (P = 0.15). No difference between the lines was observed in sartorius protein metabolism (P > 0.14). In the pectoralis major muscle, chicks of both lines receiving an adequate lysine intake also exhibited similar protein turnover rates. However, in chicks fed the lysine-deficient (0.75% lysine) diet, FSR and Cs were higher in QL than in CL chicks (P < 0.05), and FBR tended (P = 0.07) to be higher in QL chicks. This increased protein turnover in the QL birds on the lysine-deficient diet suggests that the responsiveness of muscle protein metabolism to amino acid supply is modified by genetic selection for breast development.
Mathematical methods for pattern recognition: logic, optimization, algebraic approaches

The paper is devoted to a brief survey of some new approaches and mathematical methods for solving recognition (supervised classification) problems developed by authors. The methods based on logical approach are first discussed. Next, multiparametric recognition model optimization (training) problems are studied. Finally, a construction of optimal solutions for recognition problems based on a two-level information handling process is presented.
Photodynamic therapy of epithelial skin tumours using delta‐aminolaevulinic acid and desferrioxamine

Photodynamic therapy (PDT) uses photosensitizing drugs, such as porphyrins, and light for cancer treatment. In the present clinical study we employed topical application of the porphyrin precursor delta‐aminolaevulinic acid (ALA) in combination with desferrioxamine (df) for the induction of endogenous porphyrin synthesis. Irradiation was performed with a light source consisting of a halogen lamp with a red filter and a fibreoptic device. Irradiances ranged from 50 to 300mW/cm2. We treated 49 patients with this PDT regimen. In 32 patients we treated a total of 34 superficial basal cell carcinomas (BCCs) and 22 nodular BCCs, in nine patients 43 solar keratoses, and in eight patients 10 lesions of Bowen's disease. After a single treatment, 30 (88.2%) of the superficial and seven (31.8%) of the nodular BCCs, 35 of 43 (81.4%) solar keratoses. and three (30%) of the Bowen's disease lesions showed complete remission. The post‐treatment observation period was up to 20 months. Repeat therapy was required in six nodular and four superficial BCCs. Biopsies were obtained before treatment, and at variable intervals after treatment. Topical PDT of skin tumours with ALA‐df‐induced porphyrins is effective in the management of epithelial skin tumours.
La souffrance comme expérience partagée. L’accompagnement de patients en soins palliatifs

Partager la souffrance est devenu l’une des conditions prealables essentielles pour recouvrer dignite et espoir. Depuis la fin des annees 1980 et la naissance des unites de soins palliatifs en France, le traitement de la douleur en general, et de la douleur des personnes atteintes de maladies incurables en particulier, a beaucoup evolue. Des progres considerables ont ete accomplis dans la reconnaissance de la dignite du malade et de son integrite. L’approche de l’integralite de la vie humaine.
Resistive Loss Modeling for Inverter-fed Induction Motors

Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto. fi Author Huynh Van Khang Name of the doctoral dissertation Resistive Loss Modelling for Inverter-fed Induction Motors Publisher School of Electrical Engineering Unit Department of Electrical Engineering Series Aalto University publication series DOCTORAL DISSERTATIONS 162/2012 Field of research Electromechanics Manuscript submitted 10 August 2012 Date of the defence 21 December 2012 Permission to publish granted (date) 25 October 2012 Language English Monograph Article dissertation (summary + original articles) Abstract The aim of this research is to model resistive losses in induction motors. The resistive losses in the form-wound stator windings of induction motors were modelled by using timediscretized finite element analysis (FEA) and circuit models. Loss modelling with a high level of accuracy by means of FEA can be used in the demanding design of electrical machines, typically for high-power and high-speed induction motors in spite of its high computational cost. Alternatively, the equivalent circuits served as a cheap computational tool for the rapid estimation of the resistive losses of 37-kW and 1250-kW machines for motor drives without using the machine data, typically the machine structure and materials.The aim of this research is to model resistive losses in induction motors. The resistive losses in the form-wound stator windings of induction motors were modelled by using timediscretized finite element analysis (FEA) and circuit models. Loss modelling with a high level of accuracy by means of FEA can be used in the demanding design of electrical machines, typically for high-power and high-speed induction motors in spite of its high computational cost. Alternatively, the equivalent circuits served as a cheap computational tool for the rapid estimation of the resistive losses of 37-kW and 1250-kW machines for motor drives without using the machine data, typically the machine structure and materials. Electromagnetic losses lead to a temperature rise in electrical machines. As a result, temperature rise analysis is required to check whether the induction motors that are designed fulfill the IEC standard or design constraints. Thermal analysis employs FEA or a thermal network depending on the specific problems being studied. In this study, Finite Element Method Magnetics a public domain code was used to analyse the temperature rise of the form-wound stator windings of a 1250-kW induction motor. The thermal network was used in the thermal analysis of a 300-kW high-speed motor using form-wound stator windings. After the loss and thermal information have been collected, the losses in the stator form-wound windings of the induction motors are minimized in collaboration with temperature rise checking in the design stage. In addition, the loss and temperature rise analysis may offer numerical data to evaluate the possibility of using the form-wound windings for high-speed induction motors.
Beta-cyanoglutamic acid, a new antifungal amino acid from a streptomycete.

before sterilization, and incubated at 28°C for 4 days on a rotary shaker (200rpm). For production of the antibiotic, 5ml of the seed culture was transferred to 100-ml of production medium(corn starch 2%, soy bean meal 3%, MgSO4-7H2O 0.33% and CaCO3 1%, pH 7.0) in a 500-ml Erlenmeyer flask and the fermentation was carried out at 28°C for 5 days. The antibiotic production was monitored by the liquid micro-dilution method using Candida albicans A9540 as tester. The broth filtrate (8 liters) was stirred with active charcoal (80g) for one hour and filtered. The filtrate was passed through a column of Dowex 1 x 2 (350ml, OH~ form) followed by rinsing with one liter of water. The active fractions collected with a linearly increasing NaCl concentration gradient from 0 to 0.6mwere combinedand concentrated in vacuo. After desalted by Sephadex LH-20 column chromatography (40 i.d. x 750mm, 50% methanol), 2.82g of a crude powder was obtained and dissolved in a small volumeof water. The solution was charged on a column ofDEAE-Sephadex A-25 (OH form, 40 i.d. x490mm), and the elution was carried out with a linearly increasing NaCl concentration gradient from 0.05 m to 0.15 m. The active fractions were combined and desalted by Sephadex LH-20 column chromatography with water. The active eluate fractions were charged on Dowex 50w x 8 (H+ form, 20 i.d. x200mm) and eluted with 3% NH4OH. Concentration of the eluate to dryness under reduced pressure afforded 272mg of 1. The physico-chemical properties of 1 were as follows: MP 205°C (dec, Na salt); [a]£7 -24.0° (c
MULTIPLE PRIMARY TUMOURS A IN DOG. A CASE REPORT

The work reports a rare case of canine two primary malignant tumours concurrent with one benign tumour occurring within a single organism. Soft palate malignant melanoma with metastases to the regional lymph nodes and internal organs was classified as the index tumour, while thyroid carcinoma was defined as incidentaloma. The third tumour recognised was a large lipoma located in the abdominal cavity. The presented case proves that in the animal organism affected with a malignant tumour, other tumours may develop.
The relationship between customer-related social stressors and job outcomes: the mediating role of emotional exhaustion

Using the health impairment process of the Job Demands-Resources (JD-R) model as the theoretical framework, this study proposes and tests a research model that investigates the mediating role of emotional exhaustion in the relationship between customer-related social stressors and job outcomes. Job performance, extra-role customer service, and turnover intentions are three job outcomes used in the current study. Respondents were full-time frontline hotel employees in Cameroon. Data were obtained from these employees with a time lag of one month. The results of structural equation modelling (SEM) suggest that emotional exhaustion fully mediates the relationship between customer-related social stressors, as manifested by disproportionate customer expectations (DCE), customer verbal aggression (CVA), disliked customers (DC), and ambiguous customer expectations (ACE), and the aforementioned job outcomes. Specifically, the results suggest that the indicators of customer-related social stressors jointly affect emotional exhaustion that, in turn, leads to negative job outcomes such as poor job performance, reduced extra-role customer service, and increased turnover intentions.
Comparaison Balanced Scorecard - Navigator

Cet article a pour objectif de decrire et de comparer deux modeles de tableaux de bord strategique : le modele Anglo-Saxon, connu sous le nom de Balanced Scorecard et le modele Scandinave, dont l'application la plus connue a ete developpe au sein de l'entreprise Skandia sous le nom de Navigator.