Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of low and high birthweight among the James Bay Cree of northern Quebec.

cator of neonatal health. Aboriginal women tend to give birth to a greater percentage of high birthweight babies than non-Aboriginal women. However, the birthweight distribution among the Canadian native population and particularly among the Cree has not been well documented. The aim of this study was to document the birthweight distribution, determine the prevalence of low and high birthweight, and examine the secular trends of these indicators among the northern Quebec James Bay Cree.
On Representing Aesthetic Values of Literary Work in Literary Translation

The beauty of literary translation is determined by the artistic nature of the original work. Therefore, how to represent its aesthetic values should be considered the ultimate objective of literary translation. This paper, which is theoretically based on formal and non-formal aesthetic constituents of literature classified by the Chinese translation theorist Liu Miqing as well as traditional Chinese philology and modern literature stylistics, discusses extensively how to succeed in representing aesthetic values of literary works from two aspects, i.e., formal aesthetic markers and non-formal aesthetic markers. It also points out that since in a literary work formal markers and non-formal markers are really inseparable, the proper combination of the two can provide a satisfactory solution.
Mycorrhizal colonization and nutrient uptake of dry bean in manure and compost manure treated subsoil and untreated topsoil and subsoil

Abstract Eroded or leveled Portneuf silt loam soils (coarse‐silty mixed mesic Durixerollic Calciorthid) have been restored to topsoil productivity levels by manure application, but not by other organic sources such as cheese whey. In dry bean (Phaseolus vulgaris L. cv. Viva), only soil organic matter and Zn concentration of leaf tissue correlated with improved yields. Manure application could potentially increase or decrease mycorrhizal colonization depending on which factors dominate. Manured and unmanured soils from a long‐term field experiment were sampled and mycorrhizal spores were quantified, but there was no significant manure treatment effect on spore numbers. A greenhouse study was conducted to see if manure or composted manure freshly applied to subsoils would facilitate mycorrhizal colonization in dry bean roots compared to untreated topsoil or conventionally fertilized subsoil. Low level colonization (< 5%) was observed 21 days after planting and that increased to 58% by 56 days after planting.
NUTRIGENOMICS IN PERIODONTICS- AN OVERVIEW -

Now that we have entered the postgenomic era, the association between the potential protective role of nutrients and periodontal diseases is well established. It is likely to know that interactions between the genotype and diet are important in determining periodontal disease risk. A change in dietary pattern represents a promising approach in reducing the risk of aging by modulating gene expression. One of the most practical applications of nutritional modulation of chronic disease is that they regulate the expression of key inflammatory genes. Nutrigenomics is a branch of nutritional genomics focusing on identifying and understanding molecular- level interaction between nutrients and other dietary bioactives with the genome. New techniques and knowledge from the Human Genome Project named as nutrigenomics are currently combined with already established scientific disciplines such as pharmacogenomics and toxicogenomics. This manuscript reviews the evidence for nutritional exposures in the etiology and makes recommendations for daily nutritional intake for periodontal prevention / treatment regime.
Online Banking and Its Effect on Customers Saving Behavior: A Case of Equity Bank Kenya

iv ACKNOWLEDGEMENT . vi DEDICATION. vii LIST OF TABLES . x LIST OF FIGURES . xi ABBREVIATIONS AND ACRONYMS . xii CHAPTER ONE . 1 1.0 INTRODUCTION. 1 1.1 Bаckground of the Study . 1 1.2 Stаtement of the Problem . 8 1.3 Purpose of the Study . 9 1.4 Reseаrch Questions . 9 1.5 Significаnce of the Study . 9 1.6 Scope of the Study . 10 1.7 Definition of Terms. 10 1.8 Chаpter Summаry . 11 CHАPTER TWO . 12 2.0 LITERАTURE REVIEW . 12 2.
Operations Management: An International Perspective

This fascinating new core textbook, authored by a highly respected academic with over a decade of industry experience, takes a global and strategic approach to the important topic of operations management (OM). Integrating contemporary and traditional theories the text covers everything a student needs to understand the reality of operations in the modern world and combines the latest cutting-edge thinking with innovative learning features. Written in a concise and engaging style and based on up-to-date research in the field, the book provides a range of international case studies and examples that help students to apply theoretical knowledge to real-world practice.This is a must-have textbook for students studying Operations Management modules on undergraduate, postgraduate and MBA programmes. In addition, this is an ideal textbook to accompany modules on Operations Strategy, Production Management and Services Management.
Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly

ABSTRACT Human parainfluenza virus type 3 (HPIV3) belongs to the Paramyxoviridae family. Its three internal viral proteins, the nucleoprotein (N), the phosphoprotein (P), and the polymerase (L), form the ribonucleoprotein (RNP) complex, which encapsidates the viral genome and associates with the matrix protein (M) for virion assembly. We previously showed that the M protein expressed alone is sufficient to assemble and release virus-like particles (VLPs) and a mutant with the L305A point mutation in the M protein (ML305A) has a VLP formation ability similar to that of wild-type M protein. In addition, recombinant HPIV3 (rHPIV3) containing the ML305A mutation (rHPIV3-ML305A) could be successfully recovered. In the present study, we found that the titer of rHPIV3-ML305A was at least 10-fold lower than the titer of rHPIV3. Using VLP incorporation and coimmunoprecipitation assays, we found that VLPs expressing the M protein (M-VLPs) can efficiently incorporate N and P via an N-M or P-M interaction and ML305A-VLPs had an ability to incorporate P via a P-M interaction similar to that of M-VLPs but were unable to incorporate N and no longer interacted with N. Furthermore, we found that the incorporation of P into ML305A-VLPs but not M-VLPs was inhibited in the presence of N. In addition, we provide evidence that the C-terminal region of P is involved in its interaction with both N and M and N binding to the C-terminal region of P inhibits the incorporation of P into ML305A-VLPs. Our findings provide new molecular details to support the idea that the N-M interaction and not the P-M interaction is critical for packaging N and P into infectious viral particles. IMPORTANCE Human parainfluenza virus type 3 (HPIV3) is a nonsegmented, negative-sense, single-stranded RNA virus that belongs to the Paramyxoviridae family and can cause lower respiratory tract infections in infants and young children as well as elderly or immunocompromised individuals. However, no effective vaccine has been developed or licensed. We used virus-like particle (VLP) incorporation and coimmunoprecipitation assays to determine how the M protein assembles internal viral proteins. We demonstrate that both nucleoprotein (N) and phosphoprotein (P) can incorporate into M-VLPs and N inhibits the M-P interaction via the binding of N to the C terminus of P. We also provide additional evidence that the N-M interaction but not the P-M interaction is critical for the regulation of HPIV3 assembly. Our studies provide a more complete characterization of HPIV3 virion assembly and substantiation that N interaction with M regulates internal viral organization.
MEASUREMENT OF INTRAOCULAR DISTANCES BY ULTRASOUND AND COMPARISON BETWEEN OPTICAL AND ULTRASONIC DETERMINATIONS OF THE DEPTH OF THE ANTERIOR CHAMBER

When calculating the depth of the anterior chamber, most authors have included the thickness of the cornea. This has been done in the present investigation as well. consequently, in order to obtain the true depth of the chamber, i. e. , the distance from the posterior surface of the cornea to the anterior surface of the lens, the thickness of the cornea in the area measured must be subtracted. Table I, taken from Stenstrom (1946), lists the principal results of determinations of the depth of the anterior chamber made in the 19th and early 20th century. The material has not, however, been divided into age groups, a matter of paramount importance, since the depth of the chamber has long been known to decrease with rising age. The results obtained by Lindstedt (1913), Raeder (1922), StenstrGm (1946) and Tornquist (1953) are collected in table 11. Since Tornquist did not include the thickness of the cornea in his calculations, this must be taken into account when comparing the values. The measurements given in table I1 were made with various optical methods. Several photographic techniques have been devised for measuring the
Two Forms of the γ‐Aminobutyric Acid Synthetic Enzyme Glutamate Decarboxylase Have Distinct Intraneuronal Distributions and Cofactor Interactions

Abstract: Glutamate decarboxylase (GAD) catalyzes the production of γ‐aminobutyric acid (GABA), a major inhibitory neurotransmitter. The mammalian brain contains two forms of GAD, with Ms of 67,000 and 65,000 (GAD67 and GAD65). Using a new antiserum specific for GAD67 and a monoclonal antibody specific for GAD65, we show that the two forms of GAD differ in their intraneuronal distributions: GAD67 is widely distributed throughout the neuron, whereas GAD65 lies primarily in axon terminals. In brain extracts, almost all GAD67 is in an active holoenzyme form, saturated with its cofactor, pyridoxal phosphate. In contrast, only about half of GAD65 (which is found in synaptic terminals) exists as active holoenzyme. We suggest that the relative levels of apo‐GAD65 and holo‐GAD65 in synaptic terminals may couple GABA production to neuronal activity.
Rule of Fives: Identifying Critical Misalignment of Strategic Choices in Organizational Design

Business leaders, consultants, teaching professionals, researchers, and academic theorists have long recognized the importance of strategic choice alignment as a determinant of firm performance and as a measure of strategic leadership competence. But how do we know which organizational elements need to be aligned? How do we determine if those elements are aligned or misaligned, and how do we prioritize misalignments which most urgently need to be corrected? This paper proposes a ten-element best-fit alignment stack of strategic choice meta-frameworks drawn from the author’s expe-rience as both a business leader and graduate school professor and offers a simple assessment mechanism that identifies the most critical misalignments in a firm.
The chemistry of negotiation: Rhythmic, glycan-driven acidification in a symbiotic conversation

Significance The chemical dialog through which a host promotes long-term symbioses with particular microbial partners remains largely unexplored, especially within complex consortia like the human microbiota. Natural, monospecific associations, including that between bobtail squid and Vibrio fischeri, have proved useful for discovering shared strategies, such as rhythmic microbial signaling and symbiosis-induced development, subsequently found in mammalian associations. Here, we demonstrate that symbiont metabolism is driven by a diel provision of a squid-derived glycan, resulting in tissue acidification. This event alters bacterial physiology, favoring the cyclic production of bioluminescence, the functional basis of the symbiosis. More generally, studies of this association can help reveal mechanisms by which other hosts modulate the chemistry of symbiosis to regulate microbial community function. Glycans have emerged as critical determinants of immune maturation, microbial nutrition, and host health in diverse symbioses. In this study, we asked how cyclic delivery of a single host-derived glycan contributes to the dynamic stability of the mutualism between the squid Euprymna scolopes and its specific, bioluminescent symbiont, Vibrio fischeri. V. fischeri colonizes the crypts of a host organ that is used for behavioral light production. E. scolopes synthesizes the polymeric glycan chitin in macrophage-like immune cells called hemocytes. We show here that, just before dusk, hemocytes migrate from the vasculature into the symbiotic crypts, where they lyse and release particulate chitin, a behavior that is established only in the mature symbiosis. Diel transcriptional rhythms in both partners further indicate that the chitin is provided and metabolized only at night. A V. fischeri mutant defective in chitin catabolism was able to maintain a normal symbiont population level, but only until the symbiotic organ reached maturity (∼4 wk after colonization); this result provided a direct link between chitin utilization and symbiont persistence. Finally, catabolism of chitin by the symbionts was also specifically required for a periodic acidification of the adult crypts each night. This acidification, which increases the level of oxygen available to the symbionts, enhances their capacity to produce bioluminescence at night. We propose that other animal hosts may similarly regulate the activities of epithelium-associated microbial communities through the strategic provision of specific nutrients, whose catabolism modulates conditions like pH or anoxia in their symbionts’ habitat.
Optimalidad en la frontera de las restricciones en programación polinómica

LA MEMORIA ESTA DIVIDIDA EN TRES CAPITULOS Y UN APENDICE, EN LA MISMA SE ABORDAN Y RESUELVEN ALGUNOS PROBLEMAS PENDIENTES DE LA PROGRAMACION NO LINEAL DE LA CONVEXA COMO CASO PARTICULAR DE LA ANTERIOR (CAPITULO 1) Y ESTUDIA EN PROFUNDIDAD LA PROGRAMACION POLINOMICA (CAPITULO 2 Y 3). EN EL APENDICE SE RECOGEN ALGUNOS TEOREMAS DE PROGRAMACION CONVEXA Y DE TOPOLOGIA QUE SIRVEN DE APOYO PARA OBTENER DETERMINADOS RESULTADOS DE ESTE TRABAJO. LOS RESULTADOS ORIGINALES QUE ESTABLECEMOS SE REFIEREN A: 1) CARACTERIZACION DEL OPTIMO EN LA FRONTERA DE LAS RESTRICCIONES EN PROGRAMACION NO LINEAL Y EN PARTICULAR EN PROGRAMACION CONVEXA. 2) UNICIDAD DEL OPTIMO EN PROGRAMACION CONVEXA. COMO CONSECUENCIA DE ESTOS DOS PRIMEROS PUNTOS SE FORMULAN NUEVOS TEOREMAS DE UNICIDAD Y OPTIMALIDAD EN PROGRAMACION CONVEXA. 3) TEOREMAS EQUIVALENTES AL DE KUHN Y TUCKER EN PROGRAMACION CUADRATICA. 4) OPTIMALIDAD EN LA FRONTERA DE LAS RESTRICCIONES EN PROGRAMACION POLINOMICA POSITIVA. SE DEMUESTRA, ASIMISMO, QUE LOS RESULTADOS DEL PUNTO 4) NO SON GENERALIZABLES A LA PROGRAMACION POSINOMIAL. 5) ALGORITMO PARA HALLAR EL OPTIMO EN PROGRAMACION POLINOMICA CON RESTRICCIONES LINEALES. 6) ENFOQUE DE LA PROGRAMACION POLINOMICA MEDIANTE UN PROBLEMA EQUIVALENTE DE PROGRAMACION MULTIOBJETIVO. ESTE ENFOQUE PERMITE CARACTERIZAR LAS SOLUCIONES EFICIENTES Y PRECISAR SU UBICACION, LO CUAL NO SE CONSIGUE CON EL ESTUDIO DIRECTO DEL PROGRAMA POLINOMICO.
The Development of the Physical Chemistry of Proteins, 1898–1940 *

T H E USE OF physical chemistry in the study of proteins is only one approach to the understanding of these substances-substances that were recognized from the beginning to be of central importance for living organisms. The physical chemistry of proteins is inseparable from the work of the analytical and structural chemists, so that what I have to say today is closely interwoven with the themes developed by the other speakers, notably with Dr. Fruton’s and Dr. Pirie’s contributions. Moreover it would be impossible to develop my story without some reference to the immense influence of the ultracentrifuge, and of x-ray diffraction studies, on the study of proteins by physical chemists. Dr. Williams and Dr. Hodgkin will develop those subjects in further detail, and with the personal insight that comes from their outstanding mastery of those great fields of research. The period I will discuss includes the first forty years of the twentieth century. I have chosen an opening date in 1898, when two Hungarian investigators applied reversible electromotive force measurements in a study of the binding of ions to proteins. That was elegant and solid work, to which I return later. My closing date of 1940 marks not only the onset of a cataclysmic period of world history, but it is in a way the end of an epoch in protein chemistry. By then the nature of proteins as definite molecules was generally accepted, the molecular weights of many proteins were fairly accurately known, and something was known about their general shapes. Great new scientific insights, and rapid and revolutionary advances in our understanding of proteins and their role in biology, were to follow in the years after the war; but that is not the theme of this paper. The area of science termed physical chemistry was officially baptized in the last two decades of the nineteenth century, with the work of Arrhenius, van’t Hoff, Wilhelm Ostwald, Nernst, and others. It centered
Methodes numeriques pour l'observation et la commande des systemes non lineaires

Les travaux presentes dans cette these sont consacres au probleme de la construction des observateurs pour les systemes non lineaires. La philosophie de la construction de l'observateur est basee sur les resultats d'observabilite algebrique qui permettent d'ecrire le vecteur d'etat du systeme a observer en fonction de l'entree, la sortie, et leurs derivees superieures. La notion d'observateur algebrique est introduite pour caracteriser ce nouveau type d'estimation d'etat. Dans le cas discret, de nouvelles techniques numeriques sont developpees et discutees selon la nature des mesures et la forme des modeles dynamiques des systemes a observer. Dans le cas continu, un nouveau type d'estimateur de derivees est propose. Cette estimateur de derivees constituera ensuite le noyau de l'observateur algebrique qui utilise les expressions non differentiels du vecteur d'etat. Il est montre que ces techniques permettent de s'affranchir au probleme d'emballement, le temps de convergence, l'erreur statique et la robustesse par rapport aux incertitudes des modeles. L'utilisation de ces differentiateurs en boucle fermee est approuvee par des etudes de cas. Finalement, le probleme de combinaison des observateurs algebriques et asymptotique est discute et analysee pour ameliorer les performances de l'observateur algebrique en presence du bruit.
Rule governing the division pattern in Escherichia coli minB and wild-type filaments

Escherichia coli minB mutants form anucleate minicells and multinucleate filaments. We show here that the overwhelming majority of nucleate cells contain 2n (n = 0, 1, 2, .) nucleoids, as determined by 4',6-diamidino-2-phenylindole staining, and 2n (n = 1, 2, 3, .) copies of the replication origin, as determined by flow cytometry. This shows that division sites are not chosen randomly among the available sites in minB filaments. Similarly, wild-type cells contain 2n nucleoids, both during cell division inhibition and when furazlocillin-induced filaments are allowed to divide. We conclude that the min+ function is only to prevent septation only at polar sites; the placement of internal cell division sites must obey strict rules, which are the same in minB and wild-type cells.
Polynômes orthogonaux associés à la courbe deltoïde

L'objet central de la these est l'etude des familles de polynomes orthogonaux associes a la courbe deltoide (ou hypocycloide de Steiner) dans le plan, et qui sont aussi vecteurs propres d'un operateur differentiel de diffusion dans le plan. Ces polynomes orthogonaux sont lies au systeme de racines A2, aux groupes de symetries d'un reseau triangulaire plan, ainsi qu'aux spectres des matrices de SU(3). Nous donnons tout d'abord des formules de recurrence, des fonctions generatrices, ainsi que des representations des polynomes dans quelques cas speciaux. Nous nous interessons ensuite aux inegalites de courbure-dimension satisfaites par l'operateur associe, ce qui nous permet d'obtenir des bornes uniformes sur ces polynomes, ainsi que diverses caracterisations d'inegalites de Sobolev associees. Puis nous etudions les h-transformations, qui sont liees aux conditionnements des processus associes a rester dans un domaine donne. Nous montrons que de facon generale, lorsqu'un operateur de diffusion a comme vecteurs propres des polynomes orthogonaux, il y a toujours des h-transformations explicites associees. Nous donnons bien sur l'exemple de la deltoide, mais aussi de nombreux autres exemples qui entrent dans ce cadre, certains classiques et d'autres moins. Enfin, nous nous interessons aux proprietes d'hypergroupe associees a ces operateurs. Ces proprietes d'hypergroupe permettent de decrire tous les noyaux markoviens associes aux polynomes. Nous montrons que cette propriete est satisfaite, sous une forme particuliere, pour les polynomes associes au deltoide, ce qui nous donne le premier exemple d'hypergroupe associe a un systeme de racines An.
Role of Change Implementation Capacity on Retail SMEs Performance with Moderating Effect of High Volatile Environment

T his study analys ed the effect of change implementation capacity, one of the intangible variable of dynamic capabilities , on the firm performance. The study also provided the additional insight in understanding the direct relationship between change implementation capacity and firm performance, and indirect relationship with the moderator of high volatile environment surrounding the retail firm’s business. The data from SMEs of retail firms o perating in Malaysia were analys ed using Structural Equation Model (SEM) statistical software. The results reveal ed that change implementation capacity influenced the retail firm s to achieve greater performance and high volatile environment which positively impact the performance.
An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation

An MCM4 mutation detected in human cancer cells from endometrium was characterized. The mutation of G486D is located within MCM-box and the glycine at 486 in human MCM4 is conserved in Saccharomyces cerevisiae MCM4 and Sulfolobus solfataricus MCM. This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded. It is likely that the MCM4 mutation affects the interaction with MCM7 to destabilize the MCM4/6/7 complex. Cells with abnormal nuclear morphology were detected when the mutant MCM4 was expressed in HeLa cells, suggesting that DNA replication was perturbed in the presence of the mutant MCM4. Role of the conserved amino acid in MCM4 function is discussed.