Miracle-dz/UniFAR-FTUs huggingface dataset:
Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease

It is well established that GluA1 mediated synaptic plasticity plays a central role in the early development of AD. The complex cellular and molecular mechanisms that enable GluA1‐related synaptic regulation remain to fully understood. Particularly, understanding the mechanisms that disrupt GluA1 related synaptic plasticity is central to the development of disease‐modifying therapies which are sorely needed as the incidence of AD rises. We surmise that the published evidence establishes deficits in synaptic plasticity as a central factor of AD aetiology. We additionally highlight potential therapeutic strategies for the treatment of AD, and we delve into the roles of GluA1 in learning and memory. Particularly, we review the current understanding of the molecular interactions that confer the actions of this ubiquitous excitatory receptor subunit including post‐translational modification and accessory protein recruitment of the GluA1 subunit. These are proposed to regulate receptor trafficking, recycling, channel conductance and synaptic transmission and plasticity.
Versatile Nutraceutical Potentials of Watermelon—A Modest Fruit Loaded with Pharmaceutically Valuable Phytochemicals

Watermelon (Citrulus lantus) is an important horticultural crop which belongs to the Curcubitaceae family. The nutraceutical potential of watermelon has been illustrated by several researchers, which makes it a better choice of functional food. Watermelon has been used to treat various ailments, such as cardio-vascular diseases, aging related ailments, obesity, diabetes, ulcers, and various types of cancers. The medicinal properties of watermelon are attributed by the presence of important phytochemicals with pharmaceutical values such as lycopene, citrulline, and other polyphenolic compounds. Watermelon acts as vital source of l-citrulline, a neutral-alpha amino acid which is the precursor of l-arginine, an essential amino acid necessary for protein synthesis. Supplementation of l-citrulline and lycopene displayed numerous health benefits in in vitro and in vivo studies. Similarly, the dietary intake of watermelon has proven benefits as functional food in humans for weight management. Apart from the fruits, the extracts prepared from the seeds, sprouts, and leaves also evidenced medicinal properties. The present review provides a comprehensive overview of benefits of watermelon for the treatment of various ailments.
Mixtures of Insect-Pathogenic Viruses in a Single Virion: towards the Development of Custom-Designed Insecticides

Alphabaculoviruses are used as biological insecticides and expression vectors in biotechnology and medical applications. We demonstrate that in caterpillars infected with particular mixtures of viruses, the genomes of different baculovirus species can be enveloped together within individual virions and occluded within proteinaceous occlusion bodies. ABSTRACT Alphabaculoviruses (Baculoviridae) are pathogenic DNA viruses of Lepidoptera that have applications as the basis for biological insecticides and expression vectors in biotechnological processes. These viruses have a characteristic physical structure that facilitates the transmission of groups of genomes. We demonstrate that coinfection of a susceptible insect by two different alphabaculovirus species results in the production of mixed-virus occlusion bodies containing the parental viruses. This occurred between closely related and phylogenetically more distant alphabaculoviruses. Approximately half the virions present in proteinaceous viral occlusion bodies produced following coinfection of insects with a mixture of two alphabaculoviruses contained both viruses, indicating that the viruses coinfected and replicated in a single cell and were coenveloped within the same virion. This observation was confirmed by endpoint dilution assay. Moreover, both viruses persisted in the mixed-virus population by coinfection of insects during several rounds of insect-to-insect transmission. Coinfection by viruses that differed in genome size had unexpected results on the length of viral nucleocapsids, which differed from those of both parental viruses. These results have unique implications for the development of alphabaculoviruses as biological control agents of insect pests. IMPORTANCE Alphabaculoviruses are used as biological insecticides and expression vectors in biotechnology and medical applications. We demonstrate that in caterpillars infected with particular mixtures of viruses, the genomes of different baculovirus species can be enveloped together within individual virions and occluded within proteinaceous occlusion bodies. This results in the transmission of mixed-virus populations to the caterpillar stages of moth species. Once established, mixed-virus populations persist by coinfection of insect cells during several rounds of insect-to-insect transmission. Mixed-virus production technology opens the way to the development of custom-designed insecticides for control of different combinations of caterpillar pest species.
Sexual Behavior and Sexually Transmitted Infection Outcomes Among Men Who Have Sex With Men and Transgender Women Participating in a Study of the Timing of Antiretroviral Therapy in Lima, Peru

A randomized study of timing of antiretroviral therapy initiation (immediate vs. deferred) among Peruvian men who have sex with men and transgender women found no between-arm differences in sexual behavior and high sexually transmitted infection incidence overall. Supplemental digital content is available in the text. Background We assessed sexual behavior and incidence of sexually transmitted infections (STIs) among men who have sex with men and transgender women participating in Sabes, a study of an expanded treatment as prevention strategy focused on early diagnosis and treatment of HIV infection in Lima, Peru (2013–2017). Methods Sabes participants were tested monthly for HIV to identify acute or early infections, and HIV-positive participants were randomized to receive antiretroviral therapy immediately (immediate arm) or after 24 weeks (deferred arm) during a 48-week follow-up period. Sexual behavior was assessed at randomization (baseline) and every 12 weeks thereafter. Participants were tested for urethral and rectal chlamydia and gonorrhea and for syphilis at baseline, 12, 24, and 48 weeks. We describe patterns of sexual behavior during the 48-week follow-up period and compare sexual behavior and STI incidence between study arms. Results After randomization, 207 HIV-positive participants completed questionnaires and STI testing at 2 or more visits. After HIV diagnosis, participants in both arms reported increases in condom use with main and casual partners and decreased drug and alcohol use before or during anal sex. We observed no between-arm differences in sexual behavior. Deferred arm participants had higher incidence of chlamydia (incidence rate ratio, 2.33; 95% confidence interval, 1.14–4.77) but not gonorrhea or syphilis. Conclusions Despite reported increases in condom use, the overall high incidence of STIs reflects some ongoing condomless sex among HIV-positive men who have sex with men and transgender women, highlighting the importance of regular STI screening and counseling to support consistent condom use among HIV-positive individuals at risk for STIs.
The structure of an atmospheric warm front and its interaction with the boundary layer

The detailed structure of a warm front has been determined from JASIN radiosonde data. The warm front was the base of a sloping moist layer over 200 km wide and 100 m barf deep, within which the baroclinicity was reversed and both observed and geostrophic wind backed with height. The maximum warm baroclinicity occurred at the top of this layer, well within the warm air. The resulting differential advection was such as to m aintain potential instability within the frontal zone. The warm air above the front exhibited a lam inar structure with two main bands of moist a ir; accelerations were significant in this region. Subsidence occurred in the cold air beneath the front, although the mean vertical motion became upward before the frontal passage. The decrease in depth of the cold air boundary layer was due to both subsidence and advection.
Expert Perspective: Immune Checkpoint Inhibitors and Rheumatologic Complications

Rheumatologists increasingly receive consults for patients treated with immune checkpoint inhibitors (ICIs) for cancer. ICIs can cause inflammatory syndromes known as immune‐related adverse events (IRAEs). Several rheumatic IRAEs have been reported, including inflammatory arthritis, polymyalgia rheumatica, and myositis. For patients who present with musculoskeletal symptoms while receiving ICI therapy, it is important to have an algorithm for evaluation. The differential diagnosis includes a range of musculoskeletal syndromes, such as crystalline arthritis, mechanical issues, and osteoarthritis, in addition to IRAEs. After diagnosing a rheumatic IRAE, rheumatologists must work with the patient and the oncologist to form a treatment plan. Treatment of IRAEs is guided by severity. Evidence for management is limited to observational studies. Inflammatory arthritis and polymyalgia rheumatica are treated with nonsteroidal antiinflammatory drugs in mild cases, glucocorticoids for moderate‐to‐severe cases, and sometimes require other disease‐modifying antirheumatic drugs. Myositis due to ICIs can be accompanied by myocarditis or myasthenia gravis. Glucocorticoids and withholding the ICI are usually required to treat myositis; some patients with severe myositis require intravenous immunoglobulin or plasmapheresis. Further research is needed to optimize treatment of IRAEs that does not compromise the antitumor effect of ICIs.
Altered Circadian Activity and Sleep/Wake Rhythms in the Stable Tubule Only Polypeptide (STOP) Null Mouse Model of Schizophrenia.

Sleep and circadian rhythm disruptions commonly occur in individuals with schizophrenia. Stable tubule only polypeptide (STOP) knockout (KO) mice show behavioural impairments resembling symptoms of schizophrenia. We previously reported that STOP KO mice slept less and had more fragmented sleep and waking than wild-type littermates under a light/dark (LD) cycle (Profitt et al., Schizophr Bull. 2016; 42(5):1207-1215). Here, we assessed the circadian phenotype of male STOP KO mice by examining wheel-running activity rhythms and EEG/EMG-defined sleep/wake states under both LD and constant darkness (DD) conditions. Wheel-running activity rhythms in KO and wild-type mice were similarly entrained in LD, and had similar free-running periods in DD. The phase delay shift in response to a light pulse given early in the active phase under DD was preserved in KO mice. KO mice had markedly lower activity levels, lower amplitude activity rhythms, less stable activity onsets, and more fragmented activity than wild-type mice in both lighting conditions. KO mice also spent more time awake and less time in rapid eye movement sleep (REMS) and non-REMS (NREMS) in both LD and DD conditions, with the decrease in NREMS concentrated in the active phase. KO mice also showed altered EEG features and higher amplitude rhythms in wake and NREMS (but not REMS) amounts in both lighting conditions, with a longer free-running period in DD, compared to wild-type mice. These results indicate that the STOP null mutation in mice altered the regulation of sleep/wake physiology and activity rhythm expression, but did not grossly disrupt circadian mechanisms.
Zero-Shot Learning to Index on Semantic Trees for Scalable Image Retrieval

In this study, we develop a new approach, called zero-shot learning to index on semantic trees (LTI-ST), for efficient image indexing and scalable image retrieval. Our method learns to model the inherent correlation structure between visual representations using a binary semantic tree from training images which can be effectively transferred to new test images from unknown classes. Based on predicted correlation structure, we construct an efficient indexing scheme for the whole test image set. Unlike existing image index methods, our proposed LTI-ST method has the following two unique characteristics. First, it does not need to analyze the test images in the query database to construct the index structure. Instead, it is directly predicted by a network learnt from the training set. This zero-shot capability is critical for flexible, distributed, and scalable implementation and deployment of the image indexing and retrieval services at large scales. Second, unlike the existing distance-based index methods, our index structure is learnt using the LTI-ST deep neural network with binary encoding and decoding on a hierarchical semantic tree. Our extensive experimental results on benchmark datasets and ablation studies demonstrate that the proposed LTI-ST method outperforms existing index methods by a large margin while providing the above new capabilities which are highly desirable in practice.
Crizotinib plus erlotinib overcomes osimertinib resistance in a seriously-ill non-small cell lung cancer patient with acquired MET amplification

To the Editor: A 59-year-old Chinese man who presented with a severe cough and short of breath was admitted into hospital in October, 2018. Computed tomography scan showed a 4.0 cm 2.0 cm tumor located on the lower lobe of right lung [Figure 1A] andmulti-bone lesions, core needle biopsy was performed and adenocarcinoma was confirmed by pathologists. Diagnosis of metastatic lung adenocarcinomawithT4N3M1c in stage IVBwasmade by oncologists and pathologists. Next generation sequencing (NGS) with the biopsied tumor was done, and epidermal growth factor receptor (EGFR) exon 21 L858R mutation with mutant allele fractions (MAF) of 24.8% was found. Icotinib (Betta Pharmaceuticals Co., Ltd, Hangzhou, China), a firstgeneration EGFR tyrosine kinase inhibitor (TKI), at a dose of 125mg orally, three times a day was administered. The patient got a partial response (PR) after 5months according to the Response Evaluation Criteria in Solid Tumors 1.1 [Figure 1B]. He was found multi-brain metastasis on magnetic resonance imaging and the right lung tumor was enlarged [Figure 1C] after 9 months of icotinib treatment. NGSwasdonewith thenewbiopsiedprogressed lung tissue, which indicated that T790Mmutationwas negative and the MAF of EGFR exon 21 L858R decreased from 24.8% to 1.83%. Taking into account of the patient’s refusal of recommended chemotherapy, osimertinib (80mg once daily) was administrated to the patient. The lung tumor progressed after 1month [Figure1D]. Systemic therapywith carboplatin and pemetrexed was performed and a stable disease was reached after 2 months of the treatment. However, disease progressed after 4 months [Figure 1E], and the patient’s Eastern Cooperative Oncology Group (ECOG) performance status (PS) decreased to grade 4.NGS with serum was done and the MAF of EGFR exon 21 L858R mutation increased to 5.5%; MET amplification with a copy number of 3.1 was also found. Considering the patient’s critical ill condition, re-biopsywas unavailable and MET amplification was not re-confirmed by immunohis-
Effects of Topological Constraints on Penetration Structures of Semi-Flexible Ring Polymers

The effects of topological constraints on penetration structures of semi-flexible ring polymers in a melt are investigated using molecular dynamics simulations, considering simultaneously the effects of the chain stiffness. Three topology types of rings are considered: 01-knot (the unknotted), 31-knot and 61-knot ring polymers, respectively. With the improved algorithm to detect and quantify the inter-ring penetration (or inter-ring threading), the degree of ring threading does not increase monotonously with the chain stiffness, existing a peak value at the intermediate stiffness. It indicates that rings interpenetrate most at intermediate stiffness where there is a balance between coil expansion (favoring penetrations) and stiffness (inhibiting penetrations). Meanwhile, the inter-ring penetration would be suppressed with the knot complexity of the rings. The analysis of effective potential between the rings provides a better understanding for this non-monotonous behavior in inter-ring penetration.
Pulmonary endarterectomy in the octogenarian population: safety and outcomes.

AIMS Aim of the study was to verify the feasibility, safety and efficacy of pulmonary endarterectomy (PEA) in octogenarian patients with chronic thromboembolic pulmonary hypertension. METHODS We retrospectively analyzed 635 chronic thromboembolic pulmonary hypertension patients who underwent PEA at our center and were followed-up for at least 1 year. The end-points of the study were in-hospital mortality, hemodynamic results at 1 year and long-term survival. RESULTS In-hospital mortality was 4, 10 and 17%, respectively, for 259 patients under the age of 60 years, 352 aged between 60 and 79 years and 24 octogenarians (P = 0.006 octogenarians vs. <60 years). At multivariable analysis, age and pulmonary vascular resistances were independent risk factors for mortality (P = 0.021 and P < 0.001, respectively). At 1 year, the improvement in cardiac index was lower and the distance walked in 6 min was poorer for octogenarians than for the other two groups (both P = 0.001). Survival after hospital discharge was similar over a median follow-up period of 59 months (P = 0.113). Although in-hospital mortality and long-term survival are similar in octogenarians as compared with patients aged between 60 and 79, the improvement in cardiac index and in functional capacity at 1 year are lower in this very elderly population. CONCLUSION Age over 80 years should not be a contraindication to PEA surgery in selected patients operated on in referral centers.
Role of Job Satisfaction in Managing Sexual Satisfaction, Self Esteem and Mental Health at Work Place

The purpose of the present study to examine the role of job satisfaction on sexual satisfaction, self-esteem and mental health in corporate workers. The statistics include all employees of an IT company in the city of KOLKATA. The sample of 150 people was selected randomly for the study. From the total sample 75 males & 75 females were asked to complete questionnaires of above mentioned 4scales. Each group of males and females was consisted respondents age ranging between 30-35years. The tenure of the job was within 7 to 12 years. Both graduates & post-graduate employees were selected. All were married and their income range was in between 40,000 to 60,000.Data was analysis using descriptive statistics i.e. Mean, SD for both group males and females. Then Z test, Product Moment correlation and finally linear regression were done. In case of correlation and regression the 2 groups were clubbed as the Z values of all 4 variables were insignificant. Finding of the research indicated that there was a highly positive relationship between job satisfaction employees and global index of sexual satisfaction, self-esteem, and mental health. And finally it was found that sexual Satisfaction, self-esteem and mental health can predict well enough the job satisfaction of the present IT Sample.
OP-BRAI200010 1674..1685

Tomas Ros, Stefanie Enriquez-Geppert, Vadim Zotev, Kymberly D. Young, Guilherme Wood, Susan Whitfield-Gabrieli, Feng Wan, Patrik Vuilleumier, François Vialatte, Dimitri Van De Ville, Doron Todder, Tanju Surmeli, James S. Sulzer, Ute Strehl, Maurice Barry Sterman, Naomi J. Steiner, Bettina Sorger, Surjo R. Soekadar, Ranganatha Sitaram, Leslie H. Sherlin, Michael Schönenberg, Frank Scharnowski, Manuel Schabus, Katya Rubia, Agostinho Rosa, Miriam Reiner, Jaime A. Pineda, Christian Paret, Alexei Ossadtchi, Andrew A. Nicholson, Wenya Nan, Javier Minguez, Jean-Arthur Micoulaud-Franchi, David M.A. Mehler, Michael Lührs, Joel Lubar, Fabien Lotte, David E.J. Linden, Jarrod A. Lewis-Peacock, Mikhail A. Lebedev, Ruth A. Lanius, Andrea Kübler, Cornelia Kranczioch, Yury Koush, Lilian Konicar, Simon H. Kohl, Silivia E. Kober, Manousos A. Klados, Camille Jeunet, T.W. P. Janssen, Rene J. Huster, Kerstin Hoedlmoser, Laurence M. Hirshberg, Stephan Heunis, Talma Hendler, Michelle Hampson, Adrian G. Guggisberg, Robert Guggenberger, John H. Gruzelier, Rainer W. Göbel, Nicolas Gninenko, Alireza Gharabaghi, Paul Frewen, Thomas Fovet, Thalı́a Fernández, Carlos Escolano, Ann-Christine Ehlis, Renate Drechsler, R. Christopher deCharms, Stefan Debener, Dirk De Ridder, Eddy J. Davelaar, Marco Congedo, Marc Cavazza, Marinus H.M. Breteler, Daniel Brandeis, Jerzy Bodurka, Niels Birbaumer, Olga M. Bazanova, Beatrix Barth, Panagiotis D. Bamidis, Tibor Auer, Martijn Arns and Robert T. Thibault
Design of two low-voltage sample and hold circuits

In the resent years, there is a trend of reducing the supply voltage of integrated circuits (ICs) due to the decrease in the feature size of complementary metal-oxidesemiconductor (CMOS) process. Reducing the supply voltage is required for reliability issue in advanced CMOS process. Nevertheless, it can also reduce power dissipation. However, conventional analog circuits have difficulties to function at supply voltage less than 1.5V. In this work, two sample-and-hold (S/H) circuits, which represent one of the most common analog circuit building blocks used in data-acquisition systems, are proposed for low voltage operation. The emphasis of the first S/H circuit is on the elimination of switches that need to pass a mid-range input voltage. Furthermore, the compensation capacitor used in the amplifier is also used as the capacitor for hold mode operation. As a result, it provides a potential advantage of minimizing circuit area. The second S/H circuit is a modification of the previous proposed S/H [ 15]. Similar to the previous work, this S/H circuit uses a current source at the input stage of an amplifier to bias its input voltage near the negative rail. However, a gain compensation technique is proposed to compensate the gain error of the amplifier so that the S/H circuit with high resolution can be achieved.
Identificación de cepas del hongo Trichoderma spp. Por métodos moleculares

Las especies del genero Trichoderma poseen una gran importancia desde el punto de vista economico, ya que son capaces de producir enzimas de interes industrial, sustancias con actividad antimicrobiana, pueden ser utilizadas como agentes biocontroladores de enfermedades en plantas e incluso se han reportado como patogenos oportunistas en pacientes humanos inmunosuprimidos. De esta forma, la identificacion correcta de estas especies es un paso fundamnetal para su manejo biotecnologico. Los metodos moleculares se han convertido en una herramienta fundamental para la correcta identificacion de especies de Trichoderma . Se identificaron 10 aislados a partir de cultivos monosporicos amplificando los genes ITS, tef1 y rbp2 por PCR y analizando las secuencias correspondientes. Basado en los resultados obtenidos se asignaron los siguientes epitetos especificos a los aislados en estudio: TV03 ( T. virens ); TVC24 ( T. virens ); TV30 ( T. asperellum ); TVC34 ( T. brevicompactum ); TVC35 ( T. erinaceum ); TVC36 ( T. harzianum ); TV81 ( T. virens ); ( T. koningiopsis ); TV113 ( T. spirale ) y TV217 ( T. reesei ). La identificacion de especies de Trichoderma por medio de metodos moleculares reprensenta una herramienta util, rapida y sencilla. La informacion aportada con respecto a la identidad de las especies, permitira utilizarlas en distintas areas de la biotecnologia.