Miracle-dz/UniFAR-FTUs huggingface dataset:
GUDA VARTI FOR POST-OPERATIVE PAIN MANAGEMENT- ROAD LESS TRAVELLED

Acute pain is an unpleasant sensory, emotional and mental sensation (experience) associated with vegetative signs, psychological response and changes in behavior. Post-operative pain is one such example and adequate management becomes utmost necessary. In Shalya tantra practice, proctology is the field of excellence for many practitioners and post-operative pain is an acquaintance difficult to handle. Many practitioners still resort to using contemporary I.M OR I.V analgesics for pain management which have proven ADR’S due to lack of availability of Ayurvedic analgesics for management. Vartis (suppositories) was in vogue since pre-historic times and have been mentioned in almost all Ayurvedic texts for various disorders with suitable formulations and various modes of insertion, e.g.: Ratadi varti for Shoola. Ayurveda also has a wide-range of drugs mentioned for relieving pain which have not been used to the full potential. Hence Guda varti as a drug delivery system for pain management needs to be explored in Ayurveda Shalya tantra practice.
Nucleophilic Displacement Reaction on Tosyl Cellulose by L-Methionine to the Synthesis of Novel Water-Soluble Cellulose Derivative and Its Antibacterial Activity

A novel ampholytic cellulose derivative, cellulose-L-methionine, has been synthesized by means of an esterification reaction of microcrystalline cellulose with tosyl chloride (p-TsCl) in DMAc/LiCl (8%) at 8°C that was followed by nucleophilic displacement (SN) of the tosyl group by the L-methionine amino acid. The resulting structure of cellulose-L-methionine has been characterized by elemental analysis (CHNSO), Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H-NMR), and scanning electron microscopy (SEM). The antibacterial activity of the synthesized product was screened against Gram-positive and Gram-negative microbial strains such as Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, by the agar well diffusion method, and compared with commercial antibiotics such as ampicillin and chloramphenicol. It was found that antibacterial experiment revealed excellent antibacterial activity of the cellulose-methionine with respect to a minimal inhibitory concentration (MIC) reference.
Dynamic Strategy of Keyframe Selection With PD Controller for VSLAM Systems

Keyframe (KF) selection in a KF-based visual simultaneous localization and mapping (VSLAM) system is critical. In previous studies, static thresholds have been used for KF selection decision making; however, suboptimal performance can result from the use of such thresholds. To obtain a better KF setting than that obtained with the existing methods, in this article, we introduce a dynamic KF selection strategy. By considering both the view change between camera observation and KFs in the built map and the rate of this change, we propose to dynamically adjust the threshold for KF selection. A proportion and derivative (PD) controller is designed with the feedback of estimated view change, where the PD controller output is used for KF selection. According to the experimental results, compared with the existing studies, our method can improve the precision of visual tracking by 17.5% and 16.7% based on two popular VSLAM systems.
Information Contagion and Stock Price Crash Risk

We introduce continuity and temporariness into the independent cascade model to depict information diffusion in a social network. Investor behavior changes are determined according to the process of information diffusion, and the investment portfolio model consisting of sentiments is proposed to reveal the fire sales of stocks and the resulting stock price crash risk. Therefore, the relationship between information diffusion and stock price crash risk is established, and the contagion of stock price crash risk is analyzed from the perspective of information diffusion. Furthermore, some immunization strategies of networks are compared to prevent stock price crash risk. The results show that the tendency of stock price crash risk is consistent with that of information diffusion, which indicates that information diffusion before the fire sales is the key to triggering stock price crash risk. Moreover, investors with many ties contribute more to information diffusion than others; hence, immunization strategies of networks based on global information are more effective in preventing stock price crash risk than that based on local information. This study provides a new perspective for the study of contagion risk in the stock market, and it hints at the possibility of regulatory intervention to prevent stock price crash risk.
Switchable synthesis of glycosyl selenides or diselenides with direct use of selenium as the selenating agent

Symmetrical diglycosyl-selenides or diselenides can be readily prepared with high chemoselectivity by direct use of elementary selenium as a cheap selenating agent (reduced in situ by sodium borohydride), and glycosyl iodides (or other halides) as reactive glycosyl donors. The chemoselectivity of the synthesis is critically affected by both the presence or not of triethyl phosphite, and the sodium borohydride to selenium stoichiometric ratio. Taking advantage of indications from mechanistic studies, the scope of the strategy was further extended to the synthesis of unsymmetrical diglycosyl selenides. Preliminary biological experiments evidenced an interesting antiproliferative effect of galactosyl diselenide against some tumor cell lines, otherwise negligible with the corresponding selenide.
A non‐linear adaptive excitation control scheme for feedback linearized synchronous generations in multimachine power systems

A new adaptive scheme is proposed in this paper to design excitation controllers for feedback linearized models of synchronous generators in multimachine power systems in order to ensure the stability during large disturbances. The proposed scheme uses speed deviations of synchronous generators, readily available measured physical properties of multimachine power systems, to make all generators within a power network as partially linearized as well as to provide more damping. An adaptive scheme is then used to estimate all unknown parameters which appear in the partial feedback linearizing excitation controllers in order to avoid parameter sensitivities of existing feedback linearization techniques. The overall stability of multimachine power systems is ensured through the excitation control and parameter adaptation laws. The Lyapunov stability theory is used to theoretically analyse the stability of multimachine power systems with the proposed scheme. Simulation studies are presented to evaluate the performance of the proposed excitation control scheme for two different test systems by different operating conditions including short‐circuit faults on key locations along with variations in parameters for a large duration. Furthermore, comparative results are presented to highlight the superiority of the proposed adaptive partial feedback linearizing excitation control scheme over an existing partial feedback linearizing excitation controllers.
WOMEN LISTENING TO WOMEN AT ZERO-ACQUAINTANCE: INTERPERSONAL BEFRIENDING AT THE INDIVIDUAL AND DYADIC LEVELS

ABSTRACT Tend and Befriend theory specifies interpersonal stress responses women utilize; we studied them at the individual and dyadic levels using the Social Relations Model (SRM). Speaking about stressful life events with another woman perceived as listening attentively and with interest was predicted to engender interpersonal closeness and stress reduction. In 265 dyads, women discussed stressful events with at least three other women. Then, they judged their own and their partners’ listening quality. Each predicted their partner’s judgment of their listening. Women also rated interpersonal closeness to their partners, their partners’ closeness to them, and stress. SRM revealed individual and dyadic effects on listening, interpersonal closeness, and stress. We used the SRM effect estimates in individual and dyadic phenomenological listening models. Modeling supported the prediction that perceived listening quality impacts interpersonal closeness and stress reduction. The result extended Tend and Befriend theory by demonstrating individual and dyadic support mechanisms at zero-acquaintance. The results also extended Relational Regulation Theory by showing that even conversations about stress can reduce it.
Targeting macrophage polarization for therapy of diabesity–the feasibility of early improvement of insulin sensitivity and insulin resistance-a comprehensive systematic review

The incidence of obesity is increasing in mammoth proportions so much so that associated comorbidity T2DM incidence is increasing markedly that we had to coin a term Diabesity to target both together. Earlier trying to review etiopathogenesis of both obesity and type 2 DM we found that whatever drugs that are formulated usually do not work with some complications and till now other than bariatric surgery we have no permanent cure for long term maintenance.Further T2DM might be a disease of 2 etiopathogenesis, namely inflammatory, as well as metabolic.Although metabolic inflammation has the properties of being systemic, their common initiating point is tissue resident macrophages, whose successful physiological or abnormal pathological adaptation to its microenvironment dictates disease course as well as severity. Earlierv we reviewed macrophage polarization in case of non alcoholic fatty liver disease (NAFLD) . Here we review it more comprehensively regarding crucial modes, of macrophage polarization, inflammatory, as well as non inflammatory which sees to the formation Of insulin resistance(IR) as well as Type 2 diabetes mellitus(T2DM) . Details of macrophage polarization, bioenergetics macrophage adaptations in different scenario is discussed in detail along with role of transcription factors like Interferon Regulatory Factor 5(IRF5), Nuclear Factor Kappa B(NFKB), Toll Like Receptor 4 (TLR4) Liver X Receptor (LXR), Activator Protein 1(AP1), Hypoxia Inducible Factor 1(HIF1), Signal Transducers and Activators of Transcription (STATS) in all these signaling besides per oxisome Proliferator Activated Receptor (PPAR) .
Microvessels in tumor tissue in patients with central nervous system tumors

Angiogenesis plays an essential role in the development of a tumor. The most preferred histological evaluation method of this process is the determination of microvessel density (MVD) in the biopsy. Numerous studies report the possibility of using various MRI techniques for imaging the network of neoplastic vessels and determining the angiogenesis in them, as well as the subsequent analysis of the obtained images. In this study, a classic MRI imaging with intravenous contrast agent administration was used, and in order to ensure objectification and repeatability, and to eliminate human error that may occur in classic MRI image analysis, an automatic evaluation algorithm was used to determine the degree of angiogenesis, which was then presented in the form of a statistical pixels analysis. The study involved 48 adult patients of both sexes, treated surgically at the Department of Neurosurgery, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, due to a solid brain tumor. The highest mean density of MVD microvessels in tumor tissue was observed in high-grade gliomas. The high level of MVD expression in tumors of the central nervous system showed a positive correlation with the high degree of tumor malignancy. Based on the conducted research, it was concluded that the determination of the level of MVD expression in the tumor tissue is an additional prognostic factor in neoplasms of the central nervous system. The comparison of the results obtained with the tests performed routinely translates into a more accurate selection of treatment and assessment of the prognosis for survival.
Factors Affecting Floc Properties During Aerobic Digestion: Implications for Dewatering

Laboratory aerobic digestion studies were conducted to determine the effect of divalent cations on the characteristics of aerobically digested activated sludge. Separate reactors were operated at two divalent cation concentrations. Characteristics examined included dewatering properties (cake solids, specific resistance to filtration, and capillary suction time), polymer conditioning requirement, floc strength, supernatant chemical oxygen demand (COD), supernatant turbidity, soluble cations (sodium, potassium, calcium, magnesium, and ammonium ions), soluble anions (nitrate and nitrite), and soluble exocellular polymers (proteins and polysaccharides). The reactor containing higher amounts of calcium and magnesium (1.25 mM each) exhibited better dewatering properties, higher floc strength, lower polymer conditioning requirement, lower soluble COD, lower supernatant turbidity, and lower soluble exocellular polymers than the reactor containing lower calcium and magnesium concentrations (0.40 mM each). Floc deterioration was associated with a release of soluble proteins and polysaccharides and monovalent cations (sodium and potassium) to the bulk solution. Divalent cations were not released to the bulk solution, indicating they may participate in floc binding. Mineralization of nitrogen was not affected, suggesting that aerobic digestion of activated‐sludge solids (degradation rates) was not affected. These results imply that the addition of divalent cations improves aerobic digester performance with regard to floc properties, supernatant quality (implications for recycled COD), and dewatering performance.
Hemorrhagic Shock and Resuscitation Causes Glycocalyx Shedding and Endothelial Oxidative Stress Preferentially in the Lung and Intestinal Vasculature

ABSTRACT Introduction: Hemorrhagic shock has recently been shown to cause shedding of a carbohydrate surface layer of endothelial cells known as the glycocalyx. This shedding of the glycocalyx is thought to be a mediator of the coagulopathy seen in trauma patients. Clinical studies have demonstrated increases in shed glycocalyx in the blood after trauma, and animal studies have measured glycocalyx disruption in blood vessels in the lung, skeletal muscle, and mesentery. However, no study has measured glycocalyx disruption across a wide range of vascular beds to quantify the primary locations of this shedding. Methods: In the present study, we used a rat model of hemorrhagic shock and resuscitation to more comprehensively assess glycocalyx disruption across a range of organs. Glycocalyx disruption was assessed by fluorescent-labeled wheat germ agglutinin or syndecan-1 antibody staining in flash frozen tissue. Results: We found that our model did elicit glycocalyx shedding, as assessed by an increase in plasma syndecan-1 levels. In tissue sections, we found that the greatest glycocalyx disruption occurred in vessels in the lung and intestine. Shedding to a lesser extent was observed in vessels of the brain, heart, and skeletal muscle. Liver vessel glycocalyx was unaffected, and kidney vessels, including the glomerular capillaries, displayed an increase in glycocalyx. We also measured reactive oxygen species (ROS) in the endothelial cells from these organs, and found that the greatest increase in ROS occurred in the two beds with the greatest glycocalyx shedding, the lungs, and intestine. We also detected fibrin deposition in lung vessels following hemorrhage-resuscitation. Conclusions: We conclude that the endothelium in the lungs and intestine are particularly susceptible to the oxidative stress of hemorrhage-resuscitation, as well as the resulting glycocalyx disruption. Thus, these two vessel beds may be important drivers of coagulopathy in trauma patients.
Into the unknown: The extent and boldness of firms' international footprint

Research Summary Firms make footprints as they internationalize. Going beyond simple measures of firms' internationalization, we conceptualize and measure the extent of a firm's international footprint as the number of location‐mode combinations it is active in, whereas the boldness of the footprint shows how widespread (across modes and locations) firms' international activities are, compared to other firms with similar extent. Extent describes the complexity of international activities, and boldness captures the risk‐taking associated with operating in less know contexts. Consistent with a microfoundations lens on global strategy, we find that boldness correlates with managerial risk‐taking attributes, while the extent of internationalization strongly correlates with capabilities conducive to managing more complex operations. These measures offer a highly suitable tool for analyzing the relationship between internationalization and performance. Managerial Summary Traditional ways of measuring firms' international footprints do not describe well what they do globally. We develop a more nuanced and sharper view of firms' international footprints and a new way of thinking about the roles of complexity and risk‐taking in internationalization; what we call the extent and the boldness of a footprint, respectively. The new measures are potentially particularly useful for analyzing the relationship between internationalization and performance, which is at the core of what strategy research may offer to managers and business decision‐makers. The new measures are a stepping‐stone toward a better and managerially relevant understanding of global strategy decisions.
Identification and characterization of conformation-specific cytoplasmic integrin interactors

Integrins rely on the interaction with cytosolic proteins to induce a conformational shift, which is required for their activation, to initiate intracellular signaling, to establish a connection to the actin cytoskeleton and for their trafficking through the endosomal system. They exist in at least two distinct conformations: a high affinity (‘active’) and a low affinity (‘inactive’) state for ligands. In their inactive state the transmembrane and cytoplasmic (TMcyto) domains of the two integrin subunits are associated while they become separated upon activation. In this study we developed a screening approach for the isolation and identification of cytoplasmic integrin interactors, which combines the expression of conformation-specific integrin TMcyto domains, their incorporation into bicelles as membrane mimicking system, pull-downs and high resolution mass spectrometry. We compared binding proteins of distinct integrin α or β subunits and identified proteins that interacted specifically with associated α/β TMcyto, including Lplastin (LCP1). Knockdown of LCP1 in macrophages increased αMβ2 integrin surface level and led to increased adhesion on fibrinogen and ICAM under non-stimulatory conditions. Our proteomics data offers a global view on cytoplasmic proteins interacting with different integrin classes and provides evidence for the existence and functional relevance of conformationspecific integrin interactors.
Balancing Time in College: Examining Time-Use and Academic Outcomes of Students in a Comprehensive College Transition Program

Using a randomized control trial design, this study examines the extent to which a comprehensive college transition program (CCTP) shapes students’ time-use during their first 3 years in college. The CCTP provides comprehensive student-centered support as well as a generous scholarship. We compare students who had access to the CCTP with those who only received the scholarship. Findings indicate that both student groups spent similar amounts of time working for pay, studying, and on social media, and time-use had no differential bearing on college GPA by treatment status. In an exploratory analysis of program components, we find correlational evidence that academic-related interactions with faculty are positively associated with hours spent studying. We consistently find that the strongest predictor of time-use in college is how students spend their time in high school, suggesting that interventions aimed at shaping students’ time-use may be most effective if they are targeted at students’ precollege years.
Particulate Scattering and Backscattering in Relation to the Nature of Particles in the Red Sea

Dataset of particulate scattering and backscattering coefficients, chlorophyll a, temperature, salinity and density from surface to 200 m depth for different stations in the Red Sea during different cruises. Particulate scattering and backscattering coefficient were obtained using a wetlabs ac-s sensor and a wetlabs BB9 sensor respectively. Temperature, salinity and density were obtained using a seabird CTD sensor. Chlorophyll a concentration was obtained by HPLC.
How do contingency factors influence the content of balanced scorecards? An empirical study of French intermediate-sized enterprises

Purpose Notwithstanding a number of studies that led to the development of different performance measurement systems incorporating contingency factors, very scarce research on the variety of balanced scorecards (BSCs) indicators used in performance management were carried out in France. Accordingly, the purpose of this paper is to investigate if there is a significant relationship between contingency factors and the content of balanced scorecards in terms of the degree of use and a variety of performance indicators. Design/methodology/approach In total, 2,580 French intermediate-sized enterprises (ISE) were identified through the Diane Database (Bureau Van Dijck) then contacted by the means of a survey questionnaire that was built online using LimeSurvey software. This study receives 156 complete and usable responses. The research model was tested through multiple regressions and multi-group analyses. Findings The results show that ISEs financial managers do not use, to the same extent, all the indicators constituting the four dimensions of BSCs. Therefore, BSCs implemented by French ISEs can be described as “unbalanced”. Furthermore, three contingency factors (computerization, decentralization and market listing) were found to be significantly associated with the variety and degree of use of performance indicators in balanced scorecards. The remaining contingency and control factors did not seem to influence the degree of use and variety of BSCs content. Practical implications The findings highlight the importance of developing tools that have the potential to evolve in line with organizational, environmental and technological changes. Furthermore, this paper provides food for thought for financial directors and management controllers as to how to better meet senior management, managers and operational staff information needs. Originality/value While there is scarce academic work on BSCs in ISEs, the present research is, to the best of the knowledge, one of the rarest to apply and test a contingency approach on a sample of ISEs.
Exploring innovation capabilities build up in the deployment of crop biotechnology innovation in Kenya

ABSTRACT Agro-biotechnology deployment has been very slow in Africa, yet it has potential for enhancing sustainable development and industrialization. This paper attempts to understand the underlying factors that characterize the new technologies’ deployment process. It takes buildup of innovation capabilities as the point of interrogation considering that very few products have received regulatory approval for large-scale commercialization in Africa. It uses Kenya’s agro-biotech innovation system as a case study. The study finds that creating and accumulating innovation capabilities is much broader than research and development (R & D) capability and entails institutional capabilities that are needed to enhance biotech innovation that may lead to a sustainable industrialization.