Miracle-dz/UniFAR-FTUs huggingface dataset:
Unethical employee behaviour: a review and typology

Abstract Over the past few decades, substantial work has been carried out by researchers in the field of unethical employee behaviour. While self-interest is a more focused area of research, recent studies have investigated pro-organisational unethical behaviour. Furthermore, it is known that unethical behaviour often occurs beyond the realm of conscious awareness. At present, a comprehensive review of unethical employee behaviour that explicates the various types of unethicality is still lacking. In this study, we perform a literature review and integrate the studies under the dimensions of self-interestedness and intentionality. Consequently, four distinct patterns of unethical employee behaviour emerge, which we classify into a typology comprised of four types: (1) unethical pro-self behaviour-explicit, (2) unethical pro-self behaviour-implicit, (3) unethical pro-other behaviour-explicit and (4) unethical pro-other behaviour-implicit. We contend that each of these behaviours consists of different psychological processes, discuss the individual and situational determinants of each typology and tabulate key findings. Overall, we find that the field will significantly benefit from additional impetus being placed on the under-investigated areas of unethical employee behaviours, which, according to our defined typology, includes the implicit and the pro-other types.
Effective Xultophy administration to stable blood glucose profile by Continuous Glucose Monitoring (CGM)

Type 2 diabetes mellitus (T2DM) need adequate diet, exercise and pharmacotherapy. Authors have continued diabetic practice and research on low carbohydrate diet (LCD), calorie restriction (CR), continuous glucose monitoring (CGM), and so on. The case is 50-year-old female patient with T2DM for 10 years. She has received insulin treatment with recent HbA1c 7.4 – 8.7%, then her glucose profile was studied on CGM by FreeStyle Libre. Treatment was changed from Glargine 15 units (until day 5) to Zultophy10-12 doses (after day 6), then her glucose variability showed remarkably improved. The average blood glucose on day 3, 5, 6, 8,10,13 was 174, 164, 125, 111, 101, 98 mg/dL, respectively. FreeStyle Libre showed estimated HbA1c as 6.2% and 44 mmol/mol.
Avaliação de linhagens transgênicas de Nicotiana tabacum superexpressando uma aquaporina de origem fúngica para tolerância a estresses abióticos

Aquaporins affect water transport across membranes and represent a valuable tool for biotechnological improvement of plant tolerance to environmental stresses. Nevertheless, there are no reports of transgenic plants expressing aquaporin genes of fungal origin. We previously isolated a gene encoding for an aquaporin (ThAQP), which was up-regulated in Trichoderma harzianum during interaction with the plant pathogen Fusarium solani. This gene was introduced into Nicotiana tabacum and plants were physiologically characterized. Under favorable growth conditions, transgenic progenies did not had differences in both germination and growth rates when compared to wild type. However, physiological responses under drought stress revealed that transgenic plants presented significantly higher transpiration rate, stomatal conductance, photosynthetic efficiency and faster turgor recovery than wild type. Quantitative RT-PCR analysis demonstrated the presence of ThAQP transcripts in transgenic lines, showing the cause–effect relationship between the observed phenotype and the expression of the transgene. Our results underscore the high potential of T. harzianum as a source of genes with promising applications in transgenic plants tolerant to drought stress.
Microencapsulação de probiótico utilizando proteína de farelo de arroz e maltodextrina como agentes encapsulantes e sua aplicação em iogurte

Micro-organismos probioticos promovem diversos efeitos beneficos a saude do hospedeiro. Entretanto, para que isso ocorra e necessario que este permaneca viavel no trato digestorio humano, sendo este o principal desafio para que promovam efeitos beneficos a saude do hospedeiro. Um metodo bastante utilizado para aumentar a sobrevivencia dos probioticos frente as condicoes adversas e a microencapsulacao, onde diversas sao as tecnicas e os materiais utilizados neste processo. O objetivo deste trabalho foi otimizar o processo de microencapsulacao por spray drying do Lactobacillus acidophilus La-5 utilizando proteina extraida do farelo de arroz e maltodextrina como materiais encapsulantes, por meio da aplicacao de um Delineamento Composto Central Rotacional (DCCR) 23, cujas variaveis foram temperatura do ar de entrada, vazao de entrada e razao maltodextrina/proteina do farelo de arroz como materiais de parede, e a aplicacao em iogurte. A eficiencia da microencapsulacao do L. acidophilus La-5 variou entre 79,7% a 89,9%, e as microcapsulas apresentaram tamanhos semelhantes entre os tratamentos, variando de 4,92 a 7,06 μm, baixo teor de umidade, atividade de agua e higroscopicidade, corroborando para uma maior viabilidade do L. acidophilus La-5 durante o armazenamento, que ao final de 45 dias a 4 ± 1°C permaneceu superior a 8 Log UFC.g-1 de celulas viaveis. As analises termogravimetricas, comprovaram que a microencapsulacao possibilitou um aumento da estabilidade termica ao microorganismo probiotico, e pela analise de FTIR observou-se que houve interacao entre os materiais utilizados. A sobrevivencia do L. acidophilus microencapsulado, nas solucoes simuladas dos fluidos gastrico e intestinal, foi superior a sobrevivencia do L. acidophilus na forma livre, apresentando uma reducao na viabilidade de 2,45 log e 4,83 ciclos log, respectivamente. Ja a liberacao controlada do L. acidophilus em solucao simulada do colon ocorreu em maior numero apos 1,5 horas de incubacao. As microcapsulas do melhor tratamento, definido a partir da analise de desejabilidade, foram utilizadas para a elaboracao de iogurte probiotico, sendo que o tempo de fermentacao do iogurte contendo L. acidophilus livre e microencapsulado foi de 4 horas. Durante o periodo de armazenamento refrigerado, a pos-acidificacao foi maior no iogurte contendo L. acidophilus livre, em comparacao com o iogurte contendo celulas microencapsuladas, sendo que ambas formulacoes apresentaram contagens acima do recomendado pela legislacao brasileira, mantendo sua alegacao funcional. Para a composicao centesimal, o iogurte contendo microcapsulas apresentou maior teor de proteina e carboidratos. Em relacao a avaliacao da sobrevivencia nos fluidos gastrico e intestinal simulados, o L. acidophilus microencapsulado apresentou menor reducao de viabilidade, e maior porcentagem de sobrevivencia.
Repurposing cytarabine for treating primary effusion lymphoma by targeting KSHV latent and lytic replications

Oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically linked to primary effusion lymphoma (PEL), an aggressive and non-treatable malignancy commonly found in AIDS patients. In this study, we performed a high throughput screening of 3,731 characterized compounds, and identified cytarabine approved by FDA for treating numerous types of cancer as a potent inhibitor of KSHV-induced PEL. We showed the high efficacy of cytarabine in the growth inhibition of various PEL cells by inducing cell cycle arrest and apoptosis. Cytarabine inhibited host DNA and RNA syntheses and therefore induced cellular cytotoxicity. Furthermore, cytarabine inhibited viral DNA and RNA syntheses and induced the the rapid degradation of KSHV major latent protein LANA, leading to the suppression of KSHV latent replication. Importantly, cytarabine effectively inhibited active KSHV replication and virion production in PEL cells. Finally, cytarabine treatments not only effectively inhibited the initiation and progression of PEL tumors, but also induced regression of grown PEL tumors in a xenograft mouse model. Together, our study has identified cytarabine as novel therapeutic agent for treating PEL as well as eliminating KSHV persistent infection. Importance Primary effusion lymphoma is an aggressive malignancy caused by Kaposi’s sarcoma-associated herpesvirus. The outcome of primary effusion lymphoma is dismal without specific treatment. Through a high throughput screening of characterized compounds, we identified a FDA-approved compound cytarabine as a potent inhibitor of primary effusion lymphoma. We showed that cytarabine induced regression of PEL tumors in a xenograft mouse model. Cytarabine inhibited host and viral DNA and RNA syntheses, resulting in the induction of cytotoxicity. Of interest, cytarabine induced the degradation of KSHV major latent protein LANA, hence suppressing KSHV latent replication, which is required for PEL survival. Furthermore, cytarabine inhibited KSHV lytic replication program, preventing virion production. Our findings identified cytarabine as novel therapeutic agent for treating PEL as well as for eliminating KSHV persistent infection. Since cytarabine is already approved by the FDA, it might be an ideal candidate for repurposing for PEL therapy and for further evaluation in advanced clinical trials.
Ethno-pharmacognostical Studies on Root Bark of Rubus ellipticus Smith. from Manipur

Rubus ellipticus Smith. belongs to family Rosaceae. It is one of the important ethnomedicinal plants of Manipur. The Naga tribe of Manipur uses the root bark of the said plant for curing fever since ancient times. The present study deals with comprehensive pharmacognostical studies on root bark of this plant, it includes macroscopy, microscopy, preliminary phytochemical analysis and physicochemical parameters. Some diagnostic characters are presence of uniserriate root hairs, endodermal cells, stone cells and calcium oxalate crystals. Physicochemical studies revealed total ash (3.35%), acid insoluble ash (1.0%), water soluble ash (0.9%), alcohol soluble extractive (21.12%) water soluble extractive (25.3%) and chloroform extractive (1.3%). This will help in laying down pharmacopeial parameters. Keyword: Rubus ellipticus, Rosaceae, Pharmacognosy
Genetic Variation, Adaptability and Gene Expression Pplasticity in heterogeneous Environments

Natural environments change over time and space. How populations respond to different forms of environmental heterogeneity has strong impacts on the health and persistence of the populations. In my thesis, I explored the effects of temporal and spatial heterogeneity on several important aspects of populations—levels of genetic variation, the potential of future adaptation, and gene expression plasticity—using replicated experimental populations of Drosophila melanogaster evolving under alternative regimes: constant regimes maintained in either cadmiumor saltenriched larvae diets (Cad and Salt, respectively) and two heterogeneous regimes that vary either temporally (Temp) or spatially (Spatial) between the two diets. Wholegenome resequencing of these populations found that for sites likely under differential ecological selection (and those closely linked to them), the pattern of within-population diversity is Spatial > Temp > Salt, Cad. However, for sites that are not affected by differential selection, the pattern is Spatial > Salt, Cad > Temp. Quantitative genetic variance patterns for three fitness related traits are partially consistent with the genomic diversity. Spatial populations tend to harbor more genetic variation than Temp populations or those under a constant environment that is the same as the assay environment. The adaptability of these populations was further assessed by exposing them to high temperature while being maintained in their original larval diet regimes. Both types
Population Viability of Nonnative Mediterranean House Geckos (Hemidactylus turcicus) at an Urban Site Near the Northern Invasion Front

Abstract Biological invasions are one of the most serious threats to biodiversity conservation. Although success and impacts of many invaders, particularly ectotherms, are likely to be limited by a combination of climatic and demographic factors, human modifications to the environment can facilitate distributional expansion into otherwise low-quality landscapes. We assessed factors that might promote or preclude population viability of a nonnative ectotherm, Hemidactylus turcicus (Mediterranean House Gecko), within an urban center at the northern periphery of its known North American range. Mediterranean House Geckos are increasingly apparent in the southeastern United States, but their potential for establishment and spread in more temperate regions is less well known. We gathered data using capture–recapture methods and the unique dorsal patterns of individual geckos. Despite a more temperate climate compared to other areas in their introduced range, and refuge temperatures falling below the critical thermal minimum previously documented for other introduced Mediterranean House Gecko populations, geckos survived the winter and reproduced successfully. Cormack–Jolly–Seber open population models did not provide definitive evidence regarding changes in population size over the study period. The tendency for this introduced species to establish populations primarily within urban centers may suggest that negative impacts associated with this northerly expansion are minor. Nonetheless, a high potential for range expansion suggests a need to assess a potentially growing suite of ecosystem interactions.
THEMED ISSUE: CANNABINOIDS RESEARCH PAPER Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease

bph_773 747.761 Background and purpose: The therapeutic potential of cannabinoids in Huntington's disease (HD) has been investigated by several groups with complex and sometimes contrasting results. We sought to examine key points of intersection between cannabinoid receptor 1 (CB1) signalling, survival and the formation of mutant huntingtin aggregates in HD. Experimental approach: Using a simplified pheochromocytoma (PC12) cell model of HD expressing exon 1 of wild-type or mutant huntingtin, we assayed cell death and aggregate formation using high-throughput cytotoxicity and image-based assays respectively. Key results: CB1 activation by HU210 conferred a small but significant level of protection against mutant huntingtin-induced cell death. Pertussis toxin uncoupled HU210 from the inhibition of cAMP, preventing rescue of cell death. Phosphorylation of extracellular signal-regulated kinase (ERK) was also critical to CB1-mediated rescue. Conversely, treatments that elevated cAMP exacerbated mutant huntingtin-induced cell death. Despite opposing effects on HD cell survival, both HU210 and compounds that elevated cAMP increased the formation of mutant huntingtin aggregates. The increase in aggregation by HU210 was insensitive to Pertussis toxin and UO126, suggesting a G-protein alpha subtype s (Gs)-linked mechanism. Conclusions and implications: We suggest that the CB1 receptor, through G-protein alpha subtype i/o (Gi/o)-linked, ERK- dependent signal transduction, is a therapeutic target in HD. However the protective potential of CB1 may be limited by promiscuous coupling to Gs, the stimulation of cAMP formation and increased aggregate formation. This may underpin the poor therapeutic efficacy of cannabinoids in more complex model systems and suggest that therapies that are selective for the Gi/o, ERK pathway may be of most benefit in HD. Abbreviations: BSA, bovine serum albumin; CB1, cannabinoid receptor 1; D1, dopamine receptor 1; D2, dopamine receptor 2; ERK, extracellular signal-regulated kinase; Gi/o, G-protein alpha subtype i/o; Gs, G-protein alpha subtype s; HD, Huntington's disease; PC12, pheochromocytoma; PKA, protein kinase A; PTX, Pertussis toxin; SFM, serum-free media; SFM/BSA, serum-free media with BSA; TFZ, tebufenozide
ConFuse: Convolutional Transform Learning Fusion Framework For Multi-Channel Data Analysis

This work addresses the problem of analyzing multi-channel time series data by proposing an unsupervised fusion framework based on convolutional transform learning. Each channel is processed by a separate 1D convolutional transform; the output of all the channels are fused by a fully connected layer of transform learning. The training procedure takes advantage of the proximal interpretation of activation functions. We apply the developed framework to multi-channel financial data for stock forecasting and trading. We compare our proposed formulation with benchmark deep time series analysis networks. The results show that our method yields considerably better results than those compared against.
An Examination of Possible Maternal Effects due to Parasite and Density Stress on the Mealworm Beetle, Tenebrio molitor

Few empirical studies examine the influence that the maternal parasite environment can have on offspring fitness (maternal effects) in invertebrates. Several recent studies have found that mothers can adjust offspring phenotype to counter the negative effects of parasite infection. In this thesis I subjected the parental generation of the host species, Tenebrio molitor (Insecta: Coleoptera), to a high parasite, high density, or control treatment. Offspring were subsequently subjected to either the same stress, the alternate stress, or to the control, and fitness-related life history traits were measured in both generations. The results from this thesis do not support the hypothesis that T. molitor mothers influence offspring fitness in a positive way. Instead, maternal effects led to a reduction in offspring fitness under both types of stress. At least under some environmental conditions, females invest in their fitness at the expense of their offspring.
Variation in trophic resources in female South American sea lions at a small geographic scale

Difference among colonies in the population structure of otariids can be driven by philopatry and/or by specializations in the foraging ecology of females. In northern Patago-nia, the South American sea lion (SASL) shows some degree of spatial genetic structure among colonies from north and south zones. This study aims to explore the isotopic niche of SASL females in the last period of the pregnancy from different colonies of northern Patagonia and to consider whether the fine scale genetic spatial structuring is potentially related to variation in trophic resources. Stable isotope analysis was performed on 101 skin samples of newborn pups in 10 colonies, as a proxy for the feeding ecology of their mothers. Differences among colonies in the metrics studied revealed the plasticity of the species and support individual trophic specialization of SASL females at a small geographic scale. Also, significant differences were found in all isotopic metrics between the north and south zones. Several hypotheses were proposed to explain the differences in SASL females' isotope values (e.g., use of different foraging areas or prey, isotopic baseline variation). None-theless, further research is needed to better understand the relation between fine scale genetic structuring and the foraging ecology of SASL females.
Near-field internal wave beams in two dimensions

Abstract A new theory is presented for the generation of two-dimensional internal wave beams, including the effects of viscosity and unsteadiness on the propagation of the waves, and extending to the near field the classical theory of Lighthill for the far field. For this, the forcing is assumed to be of compact support. Several equivalent expressions of the waves are obtained, each associated with the choice of a support of simple shape embedding the actual support of the forcing. When the two match, the expression of the waves is valid everywhere in the fluid. For an oscillating body, the existence of critical points where the waves rays are tangential to the body is correctly accounted for, an essential requirement with regard to later inclusion of nonlinear effects and boundary layer eruption into the analysis, both of which take their origin at the critical points. Embedding supports in the shape of a circle, an ellipse and a strip are considered. Line forcing is also considered, on a weaker assumption of rapid decrease at infinity. The analysis reduces to the classical analysis of Hurley & Keady in the isotropic case of an oscillating circular cylinder, and is otherwise applied to four anisotropic oscillating bodies: an elliptic cylinder, a vertical plate, a vertical wave generator and a thin Gaussian bump.
Network size variation of geographical aided routing protocols in MANET

In position-based or geo-casting ad hoc networking applications, the data packets flooded in a limited area of the expected region toward the destination node. In such networks, a multi-hop routing is to followed when the position of the destination node is residing off-range the wireless transmission of the source node. Scientific literature references in this concept have been conducted depended on the diversity of quantitative metrics-tests regarding the size of the assigned networks so that this space is intended to be the variation in the density of the moving nodes (the number of nodes per unit of measurement). In this work, we studied the impact of the change in the size (area) of the ad hoc network with the concept of variation in the network's area while remaining the total number of nodes as a constant volume. In this paper, three of the position-based routing protocols have evaluated in terms of a network size variation. These routing protocols are: locations aided routing LAR, the distance routing effect algorithm for mobility DREAM, and the greedy perimeter stateless routing GPSR. With each simulation test, a quantitative metrics evaluation determined the most efficient protocol and the most efficient accessibility with the network environment changes in terms of actual workspace.
Scholastic Achievement Levels and Conformity of Junior High School Students in the Asch Experiment

We examined the influence of scholastic achievement levels on conformity behavior in the modified Asch experiment without using confederates (Mori & Arai, 2010). Four hundred and sixteen Japanese junior high school students (12 - 14 years old) were classified into three groups based on their scholastic achievement: high, middle, and low. We then created 22 same-sex groups (half male, half female). Each group included one high or low achievement “minority” student and three “majority” students who were all high or all low achievement students. The results showed that low achievement students in the minority role tended to conform more frequently than high achievement minority students—especially when amongst a high achievement majority. In addition, low achievement females showed more frequent conformity than low achievement males.
Habitat sampler—A sampling algorithm for habitat type delineation in remote sensing imagery

The management of habitats for the conservation and restoration of biodiversity in protected area networks requires an appropriate monitoring to increase our understanding of processes and dynamics in managed ecosystems. Remote sensing offers a unique potential for the derivation of coherent spatiotemporal information to report on natural or management‐induced habitat change. However, the methods used for the delineation of habitat types in remote sensing imagery depend on the extensive process of ground truth sampling as reference to construct image classifiers. In fact, the number of required reference samples is intrinsically unknown in complex scenes due to the heterogeneity of varying habitat conditions. Thus, most classifiers are not transferable in retrospective image analysis or between different ecosystems that is, however, required for an operational use of remote sensing‐based monitoring systems.