Miracle-dz/UniFAR-FTUs huggingface dataset:
Some tentative remarks on the sociolinguistic vitality of Yankunytjatjara in Coober Pedy, South Australia

This paper is a preliminary attempt to evaluate the linguistic vitality of Yankunytjatjara spoken in Coober Pedy and other communities in South Australia, with particular emphasis on extra-linguistic factors. The Western Desert dialects Yankunytjatjara and Pitjantjatjara are the two remaining ‘strong’ languages within South Australia, but considering the socio-cultural and political context wherein Indigenous Australian languages exist as spoken in decreasing numbers by members of encapsulated minorities, subject to an intrusive and increasingly dominant Euro-Australian culture, the question is how strong Yankunytjatjara really is. Different language endangerment indices are incorporated into the discussion with a view to how they apply to the study of contact-induced extensive linguistic change in general, and specifically to Yankunytjatjara.
The HIV/AIDS treatment adherence, health outcomes, and cost study: conceptual foundations and overview

A growing population of people living with HIV/AIDS have co-morbid psychiatric and substance abuse diagnoses, increasing the need for integrated services for persons with multiple diagnoses. This article reviews models of integrated services for multiply diagnosed persons living with HIV/AIDS. We focus on the HIV/AIDS Treatment Adherence, Health Outcomes and Cost Study to highlight the elements of multifaceted and integrated service delivery systems for people with HIV, substance abuse, and mental health disorders. Study organizational features and models of integrated services are discussed, including details of models for assessing mental health and substance abuse, outcomes, and the cost-effectiveness of integrated services.
Long-term clinical outcomes after cardioverter-defibrillator: does etiology of heart failure matter?

BACKGROUND European and American guidelines for implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy defibrillator (CRT-D) placement in patients with heart failure (HF) remain unchanged despite controversy and ongoing debate about HF etiology. However, currently there are limited data on the long-term follow-up of primary defibrillator therapy with regard to ischemic (ICM) and non-ischemic cardiomyopathy (NICM). The prognostic importance of the of the HF etiology is not well established. AIMS This study investigated the predictive value of the cause of heart failure. METHODS Between January 2009 and December 2013, 1073 patients with the first implantation of ICD/CRT-D from The Contemporary Modalities In Treatment of Heart Failure Registry (COMMIT-HF) registry, were selected for the study analysis. Study population was divided into two groups: ischemic (n=705, 65.7%) and non-ischemic (n=368, 34.3%). The primary end-point was long-term all-cause mortality. RESULTS The median follow-up period was 60.5 months. The primary end-point, death from any cause occurred significantly higher in ICM as compared to NICM group (35.7% vs. 26.6%, P = 0.008) Trend towards a higher out-of-hospital mortality in ICM patients was noticed (15.5% vs. 10.6, P = 0.052). The multivariate analysis revealed that among others ischemic etiology was an independent factor of long-term mortality (hazard ratio (HR) 1.43, 95% confidence interval (CI) 1.30 - 1.81, P = 0.003) Conclusions: In the real-world population, significantly worse survival of ICM in comparison with NICM is observed. Ischemic heart failure etiology is a strong independent predictor of mortality.
Assessment of loss-of-control eating in healthy youth by interview and questionnaire.

OBJECTIVE The aim of this study is to evaluate two questionnaires, an updated youth version of the questionnaire on eating and weight patterns (Questionnaire on Eating and Weight Patterns-5 Children/Adolescent [QEWP-C-5]) and the Loss-of-Control (LOC) Eating Disorder Questionnaire (LOC-ED-Q), against the Eating Disorder Examination (EDE) interview to assess the presence of LOC-eating among youth. METHOD Two-hundred and eighteen youths (12.8 ± 2.7 years) completed the QEWP-C-5, LOC-ED-Q, and EDE, depressive and anxiety questionnaires, and adiposity assessment. Sensitivity, specificity, positive-predictive value, negative-predictive value, and diagnostic accuracy were calculated; Cochran's Q and McNemar's tests were used to compare measures. Receiver operating characteristic area under the curve (AUC) analyses were performed. Mood and adiposity based on LOC-eating presence and absence based on each measure were examined. RESULTS The QEWP-C-5 and LOC-ED-Q demonstrated poor sensitivity (33%; 30%) and high specificity (95%; 96%) compared with the EDE. The AUCs suggested neither the QEWP-C-5 (0.64) nor the LOC-ED-Q (0.62) demonstrated acceptable diagnostic accuracy. Comparing distributions of LOC-eating presence between assessments, the QEWP-C-5 and EDE did not differ significantly (p = .10), while the LOC-ED-Q and EDE had significantly different distributions (p = .03). LOC-eating presence was associated with higher depressive and anxiety symptoms across all measures (ps < .02). Greater adiposity (ps < .02) was associated with LOC-eating presence on the EDE and LOC-ED-Q, and higher BMI z-score (p = .02) on the LOC-ED-Q. DISCUSSION Neither the QEWP-C-5 nor the LOC-ED-Q was sensitive for identifying LOC-eating presence as determined by the EDE, although both were associated with greater mood symptoms. Research is needed to improve self-report questionnaires to better screen for LOC-eating presence among pediatric populations.
Citomegalovirose congênita Congenital cytomegalovirus infection

Recém-nascido com idade gestacional de 37 semanas e 2 dias, de parto normal, do sexo feminino, admitido em Unidade de Terapia Intensiva Neonatal (UTIN) em dia 11 de Julho de 2009. Pesava 2.030 g; estatura 41,0 cm; perímetro cefálico 31,0 cm; boletim Apgar 8, 9 e 9, no 1o, 5o e 10o minutos, respectivamente. Teve como hipótese diagnóstica na admissão toxoplasmose congênita, devido à história materna (sorologia para toxoplasmose IgG positiva e IgM positiva com avidez de 85% no primeiro trimestre do pré-natal). A ultrassonografia (US) gestacional morfológica do primeiro trimestre mostrava calcificações intracranianas. O recém-nascido apresentava restrição de crescimento intrauterino, esplenomegalia, petéquias e plaquetopenia. Introduziu-se tratamento para toxoplasmose com sulfadiazina, pirimetamina e ácido folínico. A tomografia de crânio mostrou múltiplos focos de calcificações periventriculares bilaterais e nos núcleos da base. Devido a esses achados, foi pedida sorologia para citomegalovírus na mãe e na criança, cujos resultados foram os seguintes: na puérpera, IgM não reagente, IgG reagente; no recém-nascido, IgM e IgG reagentes. Realizadas pesquisas para células de inclusão ctitomegálica na urina do recém-nascido e reação em cadeia da polimerase (PCR), com resultados positivos. O recém-nascido recebeu alta hospitalar
Effect of rootstocks on volatile composition of Merlot wines.

BACKGROUND Scion physiology and grape quality are impacted by rootstock choice. There is little available information about rootstock effects on wine volatile composition, particularly when comparing grafted to own-rooted grapevines. This field trial was aimed to study the influence of the rootstock choice on volatile composition of Merlot wines. RESULTS Wines made from grapes harvested from own-rooted grapevines had the lowest content of (E)-3-hexenol, diethyl succinate and total ethyl esters and the highest content of 1-pentanol, 1-hexanol, (Z)-3-hexenol, diethyl malate and acetovanillone. Rootstocks such as 99R and 140 Ru lead to a higher content of total ethyl esters in wines followed by 110R, 1103P and Gravesac. According to the odor activity values, Merlot wines were characterized by roses, sweat, cheese and banana aromas. CONCLUSION This work provides valuable information about the potential impact of rootstocks on wine volatile composition for cv. Merlot wines. This article is protected by copyright. All rights reserved.
Neuropeptide Y knockdown in the dorsomedial hypothalamus improved basal and obesity-induced decrease in bone mass density.

OBJECTIVE Neuropeptide Y (NPY) has been shown to have a prominent role in the control of bone formation through the regulation of osteoblast activity. We aimed to investigate the role of hypothalamus-derived NPY in bone metabolism. METHODS Accordingly, adeno-associated virus (AAV)-mediated RNA interference (RNAi) was utilized to downregulate NPY gene expression in rats fed regular chow (RC) or a high-fat diet (HF). The serum concentrations of glucose, insulin, corticosterone, osteocalcin, insulin-like growth factor (IGF-1), triglycerides (TC), and cholesterol (TG) and fat mass and bone mineral density (BMD) were measured to assess the effect of NPY knockdown on basal and obesity-induced BMD. Forkhead transcription factor (FoxO1) and activating transcription factor 4 (ATF4) were measured to explore the molecular mechanism of the effect of dorsomedial nucleus (DMH) NPY knockdown on bone formation. RESULTS Our results showed that DMH NPY knockdown enhanced basal and the obesity-induced decrease in BMD and osteocalcin and promoted the phosphorylation of FoxO1 and reduced the expression of ATF4. CONCLUSION Our data suggest that DMH NPY knockdown can alter bone metabolism.
Systematic review and meta-analysis of the association between Epstein–Barr virus, multiple sclerosis and other risk factors

Background: Epstein–Barr virus (EBV) infection is thought to play a central role in the development of multiple sclerosis (MS). If causal, it represents a target for interventions to reduce MS risk. Objective: To examine the evidence for interaction between EBV and other risk factors, and explore mechanisms via which EBV infection may influence MS risk. Methods: Pubmed was searched using the terms ‘multiple sclerosis’ AND ‘Epstein Barr virus’, ‘multiple sclerosis’ AND EBV, ‘clinically isolated syndrome’ AND ‘Epstein Barr virus’ and ‘clinically isolated syndrome’ AND EBV. All abstracts were reviewed for possible inclusion. Results: A total of 262 full-text papers were reviewed. There was evidence of interaction on the additive scale between anti-EBV antibody titre and HLA genotype (attributable proportion due to interaction (AP) = 0.48, p < 1 × 10−4). Previous infectious mononucleosis (IM) was associated with increased odds ratio (OR) of MS in HLA-DRB1*1501 positive but not HLA-DRB1*1501 negative persons. Smoking was associated with a greater risk of MS in those with high anti-EBV antibodies (OR = 2.76) but not low anti-EBV antibodies (OR = 1.16). No interaction between EBV and risk factors was found on a multiplicative scale. Conclusion: EBV appears to interact with at least some established MS risk factors. The mechanism via which EBV influences MS risk remains unknown.
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

NF-κB is a transcription factor activated in response to inflammatory, genotoxic and oxidative stress and important for driving senescence and aging. Ataxia-telangiectasia mutated (ATM) kinase, a core component of DNA damage response signaling, activates NF-κB in response to genotoxic and oxidative stress via post-translational modifications. Here we demonstrate that ATM is activated in senescent cells in culture and murine tissues from Ercc1-deficient mouse models of accelerated aging, as well as naturally aged mice. Genetic and pharmacologic inhibition of ATM reduced activation of NF-κB and markers of senescence and the senescence-associated secretory phenotype (SASP) in senescent Ercc1-/- MEFs. Ercc1-/Δ mice heterozygous for Atm have reduced NF-κB activity and cellular senescence, improved function of muscle-derived stem/progenetor cells (MDSPCs) and extended healthspan with reduced age-related pathology especially age-related bone and intervertebral disc pathologies. In addition, treatment of Ercc1-/∆ mice with the ATM inhibitor KU-55933 suppressed markers of senescence and SASP. Taken together, these results demonstrate that the ATM kinase is a major mediator of DNA damage-induced, NF-κB-mediated cellular senescence, stem cell dysfunction and aging and thus represents a therapeutic target to slow the progression of aging.
A mirror in the sky: assessment of an augmented reality method for depicting navigational information

Abstract We investigated the efficacy of a novel augmented reality (AR) navigation display called Mirror in the Sky (MitS). AR displays can reduce the distance between virtual imagery content and the user’s view of the environment but may have limited benefit for depicting map-based survey information. MitS presents a simulated mirror in the upper visual field, which reflects the topographic layout of the terrain in front of the user. In our experiment, 28 participants used MitS and a track-up Map in virtual reality to perform a route confirmation task, which required participants to decide whether a route could be successfully navigated. A post-trial threat location recall task examined spatial awareness. On that task, accuracy, duration, and subjective workload measures favoured the Map. However, participants with virtual reality experience made more accurate route confirmation decisions with MitS than the Map. Practitioner summary: We compared an augmented reality display called Mirror in the Sky (MitS) to a conventional electronic map for route confirmation and threat location tasks. Although the electronic map showed advantages over MitS on some measures, users with some VR experience performed route confirmation more accurately with MitS than a map.
The relationship between premature ejaculation and anogenital distance

Premature ejaculation is a common male sexual disease in andrology practice. The goal of essay is to investigate the relation of anogenital distance that predicts prenatal testosterone exposure with premature ejaculation. Between January and May 2019, 150 men were participated in the study. The patients were evaluated with anamnesis and physical examination; age, smoking, alcohol consumption, intravaginal ejaculation latency time, body mass index, premature ejaculation diagnostic tool, distance from anal point to scrotum and distance from anal point to penis were recorded. According to premature ejaculation diagnostic tool score, the patients were classified as premature ejaculation group (score ≥11) and control group (score <11). The mean of the male age was 30.73 ± 4.40 years. The mean intravaginal ejaculation latency time score was 3.42 ± 2.71 min. Two groups were compared using the distance from anal point to scrotum distance from anal point to penis. In the premature ejaculation group, the distances were found lower (77.46 ± 2.31 and 54.78 ± 2.56 mm) than the control group (81.32 ± 3.11 and 58.16 ± 3.48 mm). There were statistical differences between two groups (p < .001). It was concluded that it is likely to have a negative relationship between anogenital distance and premature ejaculation diagnostic tool score.
A Promotor-Led Pilot Study to Increase Colorectal Cancer Screening in Latinos: The Juntos Contra El Cáncer Program

Background. Latinos have lower colorectal cancer (CRC) screening rates compared to other racial/ethnic groups in the United States, despite an overall increase in CRC screening over the past 10 years. To address this disparity, we implemented a promotor-led intervention to increase CRC screening test adherence in community-based settings, connecting community members with a partnering federally qualified health center. Purpose. To evaluate the Juntos Contra el Cáncer/Together Against Cancer (JUNTOS) intervention, by assessing pre–post changes in (1) CRC screening test adherence and (2) CRC knowledge and perceived barriers to CRC screening. We also assessed the feasibility and acceptability of program activities. Method. JUNTOS was a group-based intervention, delivered by promotores (community health workers), to promote CRC screening test adherence among Latino adults. The intervention consisted of a culturally tailored 2½-hour interactive workshop followed by an appointment scheduling assistance from a promotor. Workshop participants were Latino adults (males and females) aged 50 to 75 years who were not up-to-date with CRC screening guidelines. We conducted interviews before and 6 to 9 months after the workshop to assess program outcomes. Results. Of the 177 participants included, 118 reported completing the CRC screening test (66.7%) by 6 to 9 months postintervention. We observed baseline to 6- to 9-month increase in CRC knowledge and lower perceived barriers to obtaining CRC screening. Furthermore, the intervention was found to be feasible and acceptable. Conclusion. Results suggest that JUNTOS can be feasibly implemented in partnership with a federally qualified health center. The current study supports group-based CRC interventions in community and clinic settings.
Partial Zone II Resuscitative Endovascular Balloon Occlusion of the Aorta in Management of Multiple Trauma with Combined Abdominal and Pelvic Injury

Introduction: Resuscitative endovascular balloon occlusion of the aorta has been used in various clinical settings to elevate blood pressure in the setting of shock, even if the evidence base is weak with no clear indications. Case presentation: We report a case of traumatic hemorrhagic shock in which this technique was used in an unusual manner, treating obvious arterial abdominal bleeding associated with suspected pelvic arterial bleeding, in a Trauma Center where hybrid angiographic-surgical suite is not available. A 35-year-old man was involved in a traffic accident within 2 trucks. He was transported to the Major Trauma Center of an Integrated Trauma System where emergent laparotomy confirmed massive hepatic rupture and a bleeding control was obtained by large abdominal packing. Trauma team decided to considerate Resuscitative Endovascular Balloon Occlusion of the Aorta, positioning a deflated balloon in zone III to eventually manage a pelvic arterial hemorrhage, while performing Bogota Bag. Suddenly a new abdominal arterial bleeding was noted through Bogota Bag. Because Pringle maneuver was considered too difficult in this case because of liver hilum injury, the balloon was moved cranially with the aim to reach zone I. Introducer sheath displacement occurred at this time, and the balloon was then only partially inflated in zone II, usually considered too dangerous, and immediately the target systolic blood pressure of 90 mmHg was obtained. Transfer the patient into interventional radiology suite was then feasible and embolization of active bleeding by right hepatic artery and superior mesenteric artery branch, missed during first laparotomy, were performed. Balloon was definitely deflated after 50 minutes. The patient was discharged by the hospital 113 days later, fully recovered with long lasting motor rehabilitation program. Discussion: Partial zone II Resuscitative Endovascular Balloon Occlusion of the Aorta in this particular case allowed overcoming procedural mistakes without major complications and with good clinical outcome. Conclusion: Judicious manage of REBOA inflation time and amount, together with multidisciplinary contemporary damage control strategy with clear and effective team leading, is the key to effectively resuscitate multiple trauma shocked patients.
Optimizing TNFR2 antagonism for immunotherapy with tumor microenvironment specificity

Most approved cancer immunotherapies lack T‐regulatory (Treg) or tumor specificity. TNF receptor 2 (TNFR2) antibody antagonism is emerging as an attractive immunotherapy due to its tumor microenvironment (TME) specificity. Here we show that the human TNFR2 receptor is overexpressed on both human tumor cells and on human tumor‐residing Tregs, but negligibly expressed on beneficial T effectors (Teffs). Further, we found widespread, if variable, TNFR2 expression on 788 human tumor cell lines from diverse cancer tissues. These findings provided strong rationale for developing a targeted immunotherapy using a TNFR2 antibody antagonist. We designed a novel, human‐directed TNFR2 antibody antagonist and tested it for function using three cell‐based TME assays. The antagonist showed TME specificity by killing of TNFR2‐expressing tumor cells and Tregs, but sparing Teffs, which proliferated. However, the antagonist shuffled between five isoforms, only one of which showed the desirable function. We designed and tested several new chimeric human versions of the antagonist, finding that the IgG2 isotype functioned better than the IgG1 isotype. To further improve function, we introduced targeted mutations to its amino acid sequence to stabilize the natural variability of the IgG2 isotype's hinge. Altogether, our findings suggest that optimal TNFR2 antagonists are of the human IgG2 isotype, have hinge stabilization, and have wide separation of antibody arms to bind to newly synthesized TNFR2 on rapidly growing tumor cells. Antagonistic antibodies with these characteristics, when bound to TNFR2, can form a nonsignaling cell surface dimer that functions with high TME specificity.
Innate Immune Responses in Serum and Cerebrospinal Fluid from Neonates and Infants Infected with Parechovirus-A3 or Enteroviruses.

BACKGROUND Parechovirus-A3 (PeV-A3) and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive PCR result for PeV-A3 in cerebrospinal fluid (CSF) are characteristic findings. We hypothesized that innate immune responses to PeV-A3 and EV are distinct in serum and CSF. METHODS We evaluated 22 cytokines/chemokines in serum and CSF from PeV-A3- or EV-infected patients younger than 4 months in Niigata, Japan, from 2015 through 2018. Infection was diagnosed with real-time PCR followed by sequencing. Febrile neonates and infants with sepsis-like syndrome who had negative bacterial culture and viral PCR for both PeV-A and EV were also included (non-PeV-A/EV patients). RESULTS Among 192 febrile patients, we evaluated 16 PeV-A3-infected, 15 EV-infected, and 8 non-PeV-A/EV patients. Serum pro-/anti-inflammatory cytokine/chemokine levels were higher in PeV-A3-infected patients than in EV-infected patients (P<.02). While most cytokine/chemokine were elevated in CSF from EV-infected patients, levels were low or undetectable in PeV-A3-infected and non-PeV-A/EV patients (P<.001). CONCLUSIONS Distinct cytokine/chemokine patterns in serum and CSF may explain the different clinical manifestations of PeV-A3-infected and EV-infected neonates and young infants.