Miracle-dz/UniFAR-FTUs huggingface dataset:
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation

Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process. Mitophagy is also involved in cell differentiation and maturation, potentially through modulating mitochondrial metabolic reprogramming. Here we examined mitophagy that is induced upon iron chelation and found that the transcriptional activity of HIF1α, in part through upregulation of BNIP3 and NIX, is an essential mediator of this pathway in SH-SY5Y cells. In contrast, HIF1α is dispensable for mitophagy occurring upon mitochondrial depolarisation. To examine the role of this pathway in a metabolic reprogramming and differentiation context, we utilised the H9c2 cell line model of cardiomyocyte maturation. During differentiation of these cardiomyoblasts, mitophagy increased and required HIF1α-dependent upregulation of NIX. Though HIF1α was essential for expression of key cardiomyocyte markers, mitophagy was not directly required. However, enhancing mitophagy through NIX overexpression, accelerated marker gene expression. Taken together, our findings provide a molecular link between mitophagy signalling and cardiomyocyte differentiation and suggest that although mitophagy may not be essential per se, it plays a critical role in maintaining mitochondrial integrity during this energy demanding process.
Microscopic Polyangiitis Initially Presumed to Be Endocarditis

The antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitides (AAVs), which include fever of unknown origin (FUO), are rare diseases characterized by necrotizing inflammation of small blood vessels and the presence of ANCAs. Microscopic polyangiitis (MPA) is a subtype of the AAVs. Although the prevalence of AAVs has generally increased over the last 20 years, there have been rare reports from the dental and oral surgery field. In this article, we present a case of MPA suspected to be infective endocarditis (IE) following tooth extraction.
Traumatic brain injury in adults

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Falls, assaults and road traffic accidents are the most common causes, with alcohol precipitating 65% of adult cases. The incidence of TBI is highest in men. As the UK population ages, however, the incidence of TBI in the elderly is rising. Approximately 1 million people affected in the UK have long-term sequelae, and GPs should be aware of the common causes and consequences of TBI. This article will focus primarily on mild TBI in adults.
Recurrent aphthous stomatitis: A case report

Recurrent aphthous stomatitis (RAS) or recurrent aphthous an ulcer (RAU) is a common disorder affecting 5% to 66% of examined adult patient groups. There may be a female predominance in some adult and child patient. We report a case of a 30-year old male patient presented a 2-year history of episodes of multiple recurrent ulcers on the ventral surface of anterior part of tongue. Topical application of Triamcinolone acetonide 0.1%, topical lignocaine and systemic vitamin B-complex, caused an improvement of pain, discomfort and healing of the aphthous ulcer. No side effects were recorded.
Concept maps and the theory of scholar scientific knowledge

We will present here the Scientific Knowledge Theory (SKT) along with one of its possible research methodologies. That is, together with concept mapping as an algorithmic language (CMA). That is, at the moment that a given author produces a given text or hypertext, to be this an educational text, an report, a article or scientific text he "materializes" a set of ideas, hypotheses, explanatory models, theory and/or experimental facts in a written form, implied in its most general form. In this moment we have the occurrence of an "educational fact. " It is proposed here that a theory of Knowledge Transposition or Didactic Transposition, provided with a research methodology and based on pedagogical facts constitutes a branch of the social sciences. That this new theory, the "Theory of Scientific Knowledge", can be easily generalized to other forms of knowledge.
SPATIAL INTEGRATION OF VEGETABLE WHOLESALE MARKETS IN POLAND ON THE SELECTED EXAMPLE

This article attempts to verify the phenomenon of price transmission between wholesale markets of carrots in Poland. Determining the level of spatial integration of markets will indicate their efficiency and thus can make it easier for producers to take decisions about where to sell their products. The empirical data includes daily quotations of carrot prices on fruit and vegetable wholesale markets in Bronisze, Kalisz, Poznań, Radom and Sandomierz. The time range of the studies covered the years 2011–2016. This research is based on dynamic econometric methods (sVAR model) and the Granger causality tests. The research carried out using dynamic econometric methods has shown that despite the occurrence of significant variation in the level of carrot prices in the examined markets, their interaction was observed. Moreover, the results of the sVAR model estimation indicate that the changes in carrot prices on a particular market are stronger influenced by the price changes from the same market. This is an autoregressive effect. It also means that the carrot price information coming from other wholesale markets (price transmission effect) has a much weaker effect.
Vignette therapeutique de l'etudiant Comment prescrire un medicament antidiabetique oral chez un patient diabetique de type 2 avec insuffisance renale ?

Rev Med Liege 2017; 72 : 10 : 462-468 Résumé : Les patients avec un diabète de type 2 (DT2) et une insuffisance rénale chronique (IRC) sont de plus en plus nombreux, notamment parmi les sujets âgés. De façon étonnante, ce problème est souvent méconnu, voire négligé, lors de la prise en charge en pratique clinique. Pourtant, la plupart des antidiabétiques oraux (ADO) ont des limites d’utilisation en cas de diminution de la fonction rénale, soit parce qu’ils nécessitent une réduction de la posologie, soit parce qu’ils sont contre-indiqués essentiellement pour des raisons de sécurité. Cette vignette clinique a pour but de discuter les modalités d’utilisation et précautions à prendre lors de la prescription des ADO les plus utilisés, la metformine, les insulinosécrétagogues (sulfamides, répaglinide), les inhibiteurs de la dipeptidyl peptidase-4 (gliptines) et les inhibiteurs des cotransporteurs sodium-glucose de type 2 (gliflozines) chez un patient avec un DT2 et une IRC. mots-clés : Diabète de type 2 Insuffisance rénale Metformine Sulfamide Inhibiteur de la DPP-4 Inhibiteur des SGLT2 use of oRal glucose-loweRing agents in patients
Multi-agent planning by distributed constraint satisfaction

Multi-agent planning has received substantial attention in the last years. A few works have considered the translation into SAT terms, to be solved dis-tributedly by an specialized SAT solver. Here, in the context of interleaving planning and coordination, we propose an approach that uses the ABT (asynchronous backtracking) algorithm to distributedly solve the propositional formulation of a multi-agent planning instance. This algorithm, presented for distributed constraint satisfaction, is generic and provides interesting privacy properties. We show some experimental results on some real-world instances coming from standard planning competitions.
Effect of isoniazid preventive therapy on tuberculosis incidence in people living with HIV-AIDS at Hasan Sadikin hospital

Indonesia is the second largest number of tuberculosis (TB) in the world. Isoniazid Preventive Therapy (IPT) as one of the three I’s TB-HIV collaboration to manage TB in people living with HIV / AIDS (PLHIV) has not been fully performed. It is related to doubt to get rid of TB in PLHIV. This study aims to see the effect of IPT on the incidence of TB in PLHIV. This issue is a retrospective cohort study based on medical record data in HIV clinic. Inclusion criteria are PLHIV ≥ 15 years of age who were registered to visit the CST service and obtain IPT with good adherence if they were receiving ART. Of 462 patients, HIV- infected patients receiving IPT were 154 (33.3%). IPT administration has a protective effect on PLHIV where the rate of TB incidence in PLHIV who received IPT were 0.21 times lower than those who did not receive IPT (IRR = 0.21, 95% CI 0.023-0.881, p 0.008). In this population, IPT administration reduces 79% risk of PLHIV to suffer TB.IPT administration reduces the incidence of TB.
Haematological parameters, haemozoin-containing leukocytes in Sudanese children with severe Plasmodium falciparum malaria.

INTRODUCTION Haemozoin -containing leucocytes (HCL) can be used to predict severe malaria. METHODOLOGY A case -control study was conducted in Singa, Sudan, to investigate the haematological values and HCL in children with severe Plasmodium falciparum malaria. The cases were children with severe P. falciparum malaria (67). The two groups of controls were patients with uncomplicated P. falciparum malaria (63) and healthy children (50). RESULTS The mean (±SD) age was 5.5 (±3.8) years. In comparison with children with uncomplicated P. falciparum malaria, children with severe P. falciparum malaria had significantly lower haemoglobin and platelet counts, and significantly higher lymphocyte counts, red cell distribution width (RDW), and platelet distribution width (PDW). The rate of haemozoin -containing monocytes (percentage of children positive for this parameter in each group) was 91.0%, 84.6% and 50.0%, P<0.001 in children with severe P. falciparum, uncomplicated P. falciparum malaria and negative controls, respectively. Receiver Operating Characteristic (ROC) curves for blood parameters and HCL were plotted and the areas under the curve (AUC) were calculated for the prediction of severe P. falciparum malaria infection. The ROC curve analysis, showed a fair predictability of malaria for haemoglobin (AUC = 0.74, sensitivity = 76.0% and specificity = 60.3%, cut-off = 9.7g/dl), lymphocytes (AUC = 0.71, sensitivity = 71.3% and specificity = 62.2%, cut-off = 1.95×103/mm3), PDW (AUC = 0.69, sensitivity = 80.1% and specificity = 66.3%, cut-off = 15.34 %) and haemozoin in the monocytes (AUC = 0.68, sensitivity = 68.2% and specificity = 65.2%, cut-off =5.5 %). CONCLUSION RDW, PDW and HCL could be used to predict severe malaria in this setting.
A Review on diverse types of Data Mining Techniques

: In today’s world large number of applications which are used by millions of people. They produces large quantity of data. These large amount of data will be stored into large repositories. Later on with the help of data mining techniques these data items will be processed and relevant aspect can be identified. These relevant facts will be useful for various levels of decision making fact. This processed information can be in use for different organizations to know the behavior of people to whole organizations are directly linked with. But the performance of the data mining approach and techniques will be downgraded while we collect the data and classify the data into different pre set classes. Various researchers has worked on the techniques to remove these kind of problems occurs while data collection and storage. In nutshell it will enhance the data mining performances.
Twelve-Week Gait Retraining Reduced Patellofemoral Joint Stress during Running in Male Recreational Runners

Purpose To explore the changes in knee sagittal angle and moment and patellofemoral joint (PFJ) force and stress before and after 12-week gait retraining. Methods A total of 30 healthy male recreational runners were randomized into a control group (n = 15) who ran in their original strike pattern using minimalist shoes or experimental group (n = 15) who ran in a forefoot strike pattern using minimalist shoes during the 12-week gait retraining. The kinematic and kinetic data of the dominant leg of the participants during the 12 km/h running were collected by 3D motion capture systems and 3D force platforms. Besides, the biomechanical property of the PFJ was calculated on the basis of the joint force model and the regression equation of the contact area. Results After the 12-week gait retraining, 78% of the rearfoot strikers turned into forefoot strikers. Peak knee extension moment and peak PFJ stress decreased by 13.8% and 13.3% without altering the running speed, respectively. Meanwhile, no changes in maximum knee flexion angle/extension moment and PFJ force/stress were observed for the control group. Conclusion The 12-week gait retraining effectively reduced the PFJ stress, thereby providing a potential means of reducing the risk of patellofemoral pain syndrome while running.
Labor Share Heterogeneity and Fiscal Consolidation Programs

We show that the labour share of income is an important factor affecting the mechanisms behind fiscal consolidation programs, thus requiring consideration when evaluating fiscal multipliers across countries. We calibrate a life-cycle, overlapping generations model to match key characteristics of different European economies and evaluate the recessive impacts of fiscal consolidation programs. We find a positive relationship between the labour share and the impact fiscal multipliers generated by our model. This result directly follows from the higher weight of labour on production and the lower opportunity cost of leisure present in economies with a higher labour share. Following the impact period, the relationship between the labour share and the fiscal multipliers is dependent on the type of fiscal instrument employed in the consolidation.
Current Practices in UAS-based Environmental Monitoring

With the increasing role that unmanned aerial systems (UAS) are playing in data collection for environmental studies, two key challenges relate to harmonizing and providing standardized guidance for data collection, and also establishing protocols that are applicable across a broad range of environments and conditions. In this context, a network of scientists are cooperating within the framework of the Harmonious Project to develop and promote harmonized mapping strategies and disseminate operational guidance to ensure best practice for data collection and interpretation. The culmination of these efforts is summarized in the present manuscript. Through this synthesis study, we identify the many interdependencies of each step in the collection and processing chain, and outline approaches to formalize and ensure a successful workflow and product development. Given the number of environmental conditions, constraints, and variables that could possibly be explored from UAS platforms, it is impractical to provide protocols that can be applied universally under all scenarios. However, it is possible to collate and systematically order the fragmented knowledge on UAS collection and analysis to identify the best practices that can best ensure the streamlined and rigorous development of scientific products.
Event-Triggered Dissipative Filter Design for Semi-Markovian Jump Systems with Time-Varying Delays

This paper deals with the event-triggered dissipative filtering problem for semi-Markovian jump systems with time-varying delays. The purpose is to design a filter which guarantees that the filtering error system is not only stochastically stable but also satisfies dissipativity. First, based on Lyapunov–Krasovskii theory and matrix integral inequality, a sufficient condition is established for the existence of such a filter. Then, the codesign method of event-triggered matrices and the desired filter parameters is proposed. Finally, two numerical examples are given to illustrate the advantages and validity of the scheme developed in this paper.
R. Greg Bell and Igor Filatotchev and Abdul A. Rasheed Beyond product markets: new insight on liability of foreignness from capital markets

Bell, R. Greg and Filatotchev, Igor and Rasheed, Abdul A. (2012) Beyond product markets: new insight on liability of foreignness from capital markets. Journal of International Business Studies, 43 (2). pp. 107-122. ISSN 0047-2506 This version is available at: https://epub.wu. ac.at/3485/ Available in ePubWU: March 2012 ePubWU, the institutional repository of the WU Vienna University of Economics and Business, is provided by the University Library and the IT-Services. The aim is to enable open access to the scholarly output of the WU. This document is the version that has been submitted to a publisher. There are major differences between this and the publisher version, so readers are advised the check the publisher version before citing.
Right ventricle Outflow Tract Acceleration Time: Correlation with Left Ventricular Diastolic Function

Background: There are no available data about the measurement of acceleration time at the right ventricle outflow tract (AcT) and its relevance in the analysis of the left ventricular diastolic function (LVDF). Objective: To correlate AcT with echocardiographic parameters of LVDF. Method: Eighty-seven patients (58.4±14.5 years; 52% women) submitted to transthoracic echocardiogram assessing spectral and tissue Doppler of the transmitral flow and mitral annulus, AcT, left atrial volume (LAV), and pulmonary artery systolic pressure (PASP). Patients with systolic dysfunction of the LV and grades II and III diastolic dysfunction (DD) were excluded. Main analyses were performed using the Spearman’s Correlation Coefficient (SCC) and Pearson’s Linear Correlation Coefficient (PLCC). Results: A negative correlation between AcT value and age (PLCC – 0.36; Student’s t-test; p <0.001) and a positive correlation between AcT and E/A ratio (SCC 0.38; p<0.001), between AcT and E/e’ ratio (SCC 0.26; p=0.01), between AcT and E wave of the mitral flow (PLCC 0.36; p= 0.001) were found. LAV and PASP did not correlate with AcT. In patients with a normal diastolic function, AcT was higher when compared with the AcT in patients with Grade I DD (0.150±0.029ms versus 0.127±0.023ms; p<0.001; Student’s t-test). The threshold suggested in this subgroup of patients was 0.135s. Conclusions: The present study correlated, unprecedentedly, AcT with echocardiographic parameters of the LV diastolic function. AcT values lower than 0.135s were associated with grade I diastolic dysfunction and higher than 0.135s values were associated with normal diastole.
Treatment-related Complications in Childhood Acute Lymphoblastic Leukemia: Results of Medical Research Council UKALL X

Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous group of lymphoid neoplasms resulting from the proliferation of malignant lymphoid cells. The aim of this study was to evaluate treatment-related complications in children with ALL receiving the Medical Research Council (MRC) UKALL X protocol. Methods: In this retrospective cross-sectional study, children with ALL receiving the MRC UKALL X protocol from 2008 to 2015 in Bahrami University Hospital, Iran, were enrolled. The clinical and morphological features were analysed and treatment-related complications were assessed. Results: Out of 67 children with ALL receiving the MRC UKALL X protocol, 44 (65.6 %) were boys and 23 (34.4%) were girls. Seven patients (10.7%) relapsed in the three years of diagnosis, and 50 children (74.6%) had an overall survival of three years. Average age in three-year-survival group and mortality group was 6.92 (SD: 3.96) and 6.35 (SD: 7.47), respectively (P= 0.38). Conclusion: Overall survival and relapse rates in this study confirm that this protocol is an appropriate treatment strategy.
Network Interface Controller Offloading in Linux

Modern network interface controllers allow the host to offload packet processing to hardware in order to improve performance. At the present time, the advanced features are utilized in the Linux kernel by offloading the Traffic Control subsystem. Since this subsystem has been designed for a completely different purpose, its usage for hardware offloading is impractical and unreliable. Furthermore, in its current state the subsystem is not capable of utilizing all hardware features, which are often poorly documented. The presented work adopts a different approach to the problem. Five high-end controllers and their packet-processing pipelines were examined in detail. Accounting for their projected future development, common traits and features were identified. The researched information was used to draft a proposal for a new Linux subsystem, more compatible with hardware offloading than the current solution. The proposed subsystem defines a sufficiently descriptive interface to utilize the majority of hardware-offloaded features while avoiding common problems caused by excessively generalized approach of Traffic Control.
Responses of germination characteristics and antioxidant enzymes activity to different levels of hydro-priming and seed ageing in three maize (Zea mays L.) hybrids

Seed storage at unfavorable conditions of high humidity and temperature is a difficulty which decreases seed vigor and/or seed viability. Current experiment was conducted to evaluate the activity of antioxidant enzymes and seed germination characteristics after ageing on maize seeds (Zea mays L.) in the research laboratory of Razi University, Kermanshah, Iran. A three-factorial experiment was performed with completely randomized design with three replications, using three maize hybrids (SC704, SC647, SC260), and three levels of accelerated ageing (non-aged, artificially aged for 3 and 6 days at 45 oC temperature and 98% relative humidity). The hydro-priming was performed at different durations (0, 12 and 24 hours). Results indicated that germination characteristics of maize seeds were considerably affected by priming time periods. The germination characteristics of deteriorated seeds were significantly enhanced by hydro-priming, especially in 24 h priming. The highest germination characteristics and seedling length were obtained in the control (non-aged) seeds which were primed for 24 h. The lowest germination performance was obtained for the non-primed seeds after 6 days of ageing. The catalase, peroxidase and glutathione reductase activity and malondialdehyde (MDA) concentration of aged maize seeds were restored partially by hydro-priming. In fact, ageing-associated MDA decreased by priming. The results suggested that hydro-priming could improve deteriorated seed performance.