Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigallocatechin gallate: A useful therapy for cognitive disability in Down syndrome?

ABSTRACT Neurodevelopmental alterations and cognitive disability are constant features of Down syndrome (DS), a genetic condition due to triplication of chromosome 21. DYRK1A is one of the triplicated genes that is thought to be strongly involved in brain alterations. Treatment of Dyrk1A transgenic mice with epigallocatechin gallate (EGCG), an inhibitor of DYRK1A, improves cognitive performance, suggesting that EGCG may represent a suitable treatment of DS. Evidence in the Ts65Dn mouse model of DS shows that EGCG restores hippocampal development, although this effect is ephemeral. Other studies, however, show no effects of treatment on hippocampus-dependent memory. On the other hand, a pilot study in young adults with DS shows that EGCG transiently improves some aspects of memory. Interestingly, EGCG plus cognitive training engenders effects that are more prolonged. Studies in various rodent models show a positive impact of EGCG on brain and behavior, but other studies show no effect. In spite of these discrepancies, possibly due to heterogeneity of protocols/timing/species, EGCG seems to exert some beneficial effects on the brain. It is possible that protocols of periodic EGCG administration to individuals with DS (alone or in conjunction with other treatments) may prevent the disappearance of its effects.
Informal Caregivers of Cancer Patients: Perceptions About Preparedness and Support During Hospice Care

This study examined the perceptions of preparedness and support of informal caregivers of hospice oncology patients. Respondents included coresiding, proximate, and long-distance caregivers. Thematic analysis was used to analyze the qualitative data from 2 caregiver surveys, one administered prior to the care recipient's death and another completed 3 months postdeath. Respondents (N = 69) interpreted preparedness broadly and identified multiple sources of support including hospice personnel, family, friends, neighbors, and spiritual beliefs. Additionally, informational support, such as education, information, and enhanced communication were considered essential for preparing and supporting caregivers. Implications for social work research and practice are provided.
Reward abnormalities among women with full and subthreshold bulimia nervosa: a functional magnetic resonance imaging study.

OBJECTIVE To test the hypothesis that women with full and subthreshold bulimia nervosa show abnormal neural activation in response to food intake and anticipated food intake relative to healthy control women. METHOD Females with and without full/subthreshold bulimia nervosa recruited from the community (N = 26) underwent functional magnetic resonance imaging (fMRI) during receipt and anticipated receipt of chocolate milkshake and a tasteless control solution. RESULTS Women with bulimia nervosa showed trends for less activation than healthy controls in the right anterior insula in response to anticipated receipt of chocolate milkshake (vs. tasteless solution) and in the left middle frontal gyrus, right posterior insula, right precentral gyrus, and right mid dorsal insula in response to consumptions of milkshake (vs. tasteless solution). DISCUSSION Bulimia nervosa may be related to potential hypofunctioning of the brain reward system, which may lead these individuals to binge eat to compensate for this reward deficit, though the hypo-responsivity might be a result of a history of binge eating highly palatable foods.
A COMPARATIVE STUDY BETWEEN METOCLOPRAMIDE AND DEXAMETHASONE FOR PREVENTION OF POST OPERATIVE NAUSEA AND VOMITING IN LAPAROSCOPIC CHOLECYSTECTOMY

Objective: To compare the prophylactic antiemetic effect of intravenous (IV) metoclopramide with dexamethasone. Material and Methods: A prospective study of 150 patients undergoing “Laparoscopic Cholecystectomy” was carried out in the Department of Anaesthesiology, Khyber Teaching Hospital, Peshawar, from April 2009 to October 2009. Patients were divided into two groups. One group received metoclopramide 10 mg IV, while the second group received dexamethasone 8 mg IV. The anaesthetic regime and surgical procedure were standardized for all patients. Nausea and vomiting were assessed immediately after operation, at hourly intervals for 4 hours, in the recovery room, and from 4 to 24 hours in the ward. Results: The incidence of post operative nausea and vomiting (PONV), in the metoclopramide group was 20% after 0-4 hours, 50% after 4-24 hours and 70% after 0-24 hours of surgery. The incidence of PONV in dexamethasone group was 16% after 0-4 hours, 12% after 4-24 hours and 28% after 0-24 hours surgery. A statistically significant difference was observed in both groups in respect of postoperative nausea and vomiting in 4-24 hours and 0-24 hours with a p-value 0.000 each. Conclusion: Dexamethasone was found superior to metoclopramide as a prophylactic antiemetic in patients undergoing laparoscopic cholecystectomy.
Artificial neural network modeling of grinding of ductile cast iron using water based sio2 nanocoolant

This paper presents optimization of the grinding progress of ductile cast iron using water-based SiO2 nanocoolant. Conventional and water-based nanocoolant grinding was performed using a precision surface grinding machine. The study is aimed to investigate the effect of table speed and depth of cut on the surface roughness and material removal rate (MRR). Mathematical modeling is developed using the response surface method. An artificial neural network model is developed for predicting the surface roughness and MRR. Multi-layer perception and a batch back propagation algorithm are used. MLP is a gradient descent technique to minimize the error through a particular training pattern in which it adjusts the weight by a small amount at a time. From the experiment, the depth of cut is directly proportional to the surface roughness, but the table speed is inversely proportional to the surface roughness. The higher the value of the depth of cut, the lower the value of MRR, and vice versa for the table speed. It is concluded that the surface quality together with the material removal rate are the most affected by the depth of cut(s) and table speed.
A Review of How Firms Strategically Lead by Innovating Technology Within the Sharing Economy – A Case of Opportunities, Disruptions, Criticisms and Regulations

This article reviews how firms strategically lead by innovating technology within the sharing economy; highlighting the opportunities, disruptions, criticisms, and regulations associated with innovative technology. The article begins by defining sharing economy and its scale. Sharing economy is a complex phase with countless consequences that is adopted to define economic activities made possible through online transactions. To take a fair share of the market, companies use innovative technology. For example, eBay and Amazon utilize technologies such as Web 2.0 and mobile Apps to rid of market intermediaries, streamline transactions, and bring goods and services near people. Uber also allows customers to use a mobile application to reach drivers and this facilitates the sense of nearness. The use of technology in the sharing economy has many advantages. However, it carries with it some corrosive effects on the business community and society at large. Critics of technology are championing for stricter regulations. The sharing economy witnesses some pertinent disruptions caused by companies that innovate technology. They include unfair competition, lower entry barrier, regulations, quality standards, and financial sector risks. Keywords: Sharing Economy, Sharing Platform, Mobile Application, Chicken and Egg Strategy, Porter's Five Forces, Force Field Analysis, Technology, e-Business DOI : 10.7176/EJBM/11-12-01 Publication date : April 30 th 2019
Combinatorial Effects of Arginine and Fluoride on Oral Bacteria

Dental caries is closely associated with the microbial disequilibrium between acidogenic/aciduric pathogens and alkali-generating commensal residents within the dental plaque. Fluoride is a widely used anticaries agent, which promotes tooth hard-tissue remineralization and suppresses bacterial activities. Recent clinical trials have shown that oral hygiene products containing both fluoride and arginine possess a greater anticaries effect compared with those containing fluoride alone, indicating synergy between fluoride and arginine in caries management. Here, we hypothesize that arginine may augment the ecological benefit of fluoride by enriching alkali-generating bacteria in the plaque biofilm and thus synergizes with fluoride in controlling dental caries. Specifically, we assessed the combinatory effects of NaF/arginine on planktonic and biofilm cultures of Streptococcus mutans, Streptococcus sanguinis, and Porphyromonas gingivalis with checkerboard microdilution assays. The optimal NaF/arginine combinations were selected, and their combinatory effects on microbial composition were further examined in single-, dual-, and 3-species biofilm using bacterial species–specific fluorescence in situ hybridization and quantitative polymerase chain reaction. We found that arginine synergized with fluoride in suppressing acidogenic S. mutans in both planktonic and biofilm cultures. In addition, the NaF/arginine combination synergistically reduced S. mutans but enriched S. sanguinis within the multispecies biofilms. More importantly, the optimal combination of NaF/arginine maintained a “streptococcal pressure” against the potential growth of oral anaerobe P. gingivalis within the alkalized biofilm. Taken together, we conclude that the combinatory application of fluoride and arginine has a potential synergistic effect in maintaining a healthy oral microbial equilibrium and thus represents a promising ecological approach to caries management.
Parental Reaction To A Child's Hearing Impairment

Traditionally, parental reactions to a child's hearing loss have been discussed in terms of stages of the mourning process. Although this framework has been helpful in describing parent adjustment, it appears too simple. Parents react in complex ways to their children's disabilities; these complexities must be considered when working with families. A model of transition that accounts for individual differences is used to discuss the potential interaction among variables associated with the mourning process.
Constraints from Thorium/Lanthanum on Sediment Recycling at Subduction Zones and the Evolution of the Continents

Arc magmas and the continental crust share many chemical features, but a major question remains as to whether these features are created by subduction or are recycled from subducting sediment. This question is explored here using Th/La, which is low in oceanic basalts ( 0 25) and varies in arc basalts and marine sediments (0 09–0 34). Volcanic arcs form linear mixing arrays between mantle and sediment in plots of Th/La vs Sm/La. The mantle end-member for different arcs varies between highly depleted and enriched compositions. The sedimentary endmember is typically the same as local trench sediment. Thus, arc magmas inherit their Th/La from subducting sediment and high Th/La is not newly created during subduction (or by intraplate, adakite or Archaean magmatism). Instead, there is a large fractionation in Th/La within the continental crust, caused by the preferential partitioning of La over Th in mafic and accessory minerals. These observations suggest a mechanism of ‘fractionation & foundering’, whereby continents differentiate into a granitic upper crust and restite-cumulate lower crust, which periodically founders into the mantle. The bulk continental crust can reach its current elevated Th/La if arc crust differentiates and loses 25–60% of its mafic residues to foundering.
Design of Direct Power Controller for a High Power Neutral Point Clamped Converter Using Real Time Simulator

In this paper, a direct power control (DPC) strategies have been investigated in order to control a high power AC/DC converter with time variable load. This converter is composed of a three level three phase neutral point clamped (NPC) converter as rectifier and an H-bridge four quadrant current control converter. In the high power application, controller not only must adjust the desire outputs but also decrease the level of distortions which are injected to the network from the converter. Regarding to this reason and nonlinearity of the power electronic converter, the conventional controllers cannot achieve appropriate responses. In this research, the precise mathematical analysis has been employed to design the appropriate controller in order to control the time variable load. A DPC controller has been proposed and simulated using Matlab/ Simulink. In order to verify the simulation result, a real time simulatorOPAL-RThas been employed. In this paper, the dynamic response and stability of the high power NPC with variable load has been investigated and compared with conventional types using a real time simulator. The results proved that the DPC controller is more stable and has more precise outputs in comparison with conventional controller. Keywords—Direct Power Control, Three Level Rectifier, Real Time Simulator, High Power Application.
Opportunity and business challenge of marine ornamental fishes in Indonesia as a potential commodity of fisheries

The business opportunity of marine ornamental fishes is very big and promises high profits, although the challenges faced are quite great. The high interest in Indonesia’s marine ornamental fishes currently leads to the growth of fish farmers or market actors who involves in ornamental fish business as its primary commodity. This study aims to analysis the opportunities and challenges faced in marine ornamental fish business in Indonesia. The research methodology used is descriptive analysis, which describes the data obtained for further analyzed and interpreted according to existing conditions, does not evaluate and examine the hypothesis but only describe the existing information in accordance to the variables studied. The results showed that the challenge in marine ornamental fish development business is the community behaviour in marine ornamental fish catching that damage habitat and coral reef as strategic habitat of various types of consumption fish and ornamental fish. The use of explosives, toxins and other illegal fishing that requires appropriate solutions to solve it. Therefore, the socialization of the importance of environmentally friendly ornamental fish catching must be immediately delivered to the community, including rehabilitation efforts of coral reefs which are the main habitat of marine ornamental fish.
Marketing Segmentation and Fund Raising of Public Universities in South East Nigeria

This study investigated market segmentation for fundraising in public universities in South East Nigeria. The objective of the study is to establish that market segmentation is effective and efficient tool for fundraising in public universities. Descriptive survey research design was adopted through the use of questionnaire in cluster of B1 on 5 points scale which was administered on a sample size of 392 staff in public universities in the South East Nigeria. Cronbach Alpha was used to test the reliability of the research instrument and the result was correlation co-efficient 0.63. Mean and standard deviation was used to answer the research question while correlation was used to test the hypothesis at 0.05 level of significant. The result showed that market segmentation, helps in attracting donors and increasing donors’ commitment, for fundraising of public universities in South East Nigeria compared to the strategy of increasing school fees which often results in students protests. The results also showed that there was a significant relationship between market segmentation and fundraising of public universities. Based on the findings, the researcher recommends among others that public universities should adopt market segmentation in their fundraising activities, which when properly used will increase their revenue generations for improvement in infrastructure and other educational facilities. 1.
Antenna-Coupled MOSFET Bolometers for Uncooled THz Sensing

In this paper, we present a comprehensive study on the operation of an antenna-coupled THz bolometer based on a micro-machined SOI-CMOS thermal sensor. The pixels are designed to operate at room temperature in vacuum. We focus on a new planar skirt antenna, which combines high sensitivity within a 0.6-1.2 THz band and 30 ° HPBW. We present an overview of the design considerations, as well as the characterization results which were obtained with both broadband and CW THz sources. The NEP of the pixel is of the order of 25 pW/Hz 1/2, with responsivity 100 mA/W at the optimal operating point. The peak responsivity to a broadband THz signal is 600 mA/W. The ease of integration with a read-out circuit and the low power dissipation make this type of pixel a good candidate for focal plane array architecture.
A history of tissue expansion. Concepts, controversies, and complications.

BACKGROUND Tissue expansion has become a widely used adjunct in reconstruction of the skin. OBJECTIVE To trace the history of the concept of tissue expansion from the ancient to the latest medical literature. METHODS We reviewed the technologic developments in the materials and methods of tissue expansion. RESULTS Tissue expansion is of clinical importance and can be understood by the biochemical, biomechanical, and histologic features of expanded skin. CONCLUSION Tissue expansion is becoming widely used and accepted and its continued use under many circumstances is justified by the experimental and clinical results.
MicroRNAs as components of regulatory networks controlling erythropoiesis

Over the last two decades, the role of microRNAs has been extensively investigated, and it has become clear that these small non‐coding RNAs play an essential role in several biological processes including erythropoiesis and that their dysregulation is associated with pathologies. Recent technical innovations have considerably advanced this field and allowed extensive study of microRNA expression and regulation in a variety of cell types. In erythropoiesis, microRNA regulation is involved at defined stages and promotes either stem cell proliferation or erythroid cell differentiation. In this review, while recapitulating the maturation steps of erythroid cells, we discuss the progresses in our understanding of microRNA regulation in the erythroid lineage and their contribution to erythroid disorders.
Adopting Big Data Analytics Strategy in Telecommunication Industry

Nowadays, adopting big data is a reality. Telecommunication company or telco must find the right solution to store all information available across the organization to maximize revenue using the analytics. The solution must be able to harness the large volume, variety, and velocity of the data available. One of the challenging actions is how to perform decision making and analysis in real-time. Some of the operational decisions may not comply with the corporation policy which makes it hard to keep up with the modern evolving business environment. Telco needs a platform to improve the business process and sustainable and profitable growth. The significant impacts should involve improvements of the customer experience and more reliable network quality, thereby reducing the customer churn rate. Big data and machine learning represent today's trends for the analytics. With big data analytics, the service provider can utilize the full potential of their data set by correlating, processing, and deciphering the hidden information from it. The conventional machine learning tools without big data are becoming inadequate as the trends shift towards distributed and real-time processing. The service provider needs the solution big data-driven which supports them to achieve timely manner and more accurate insights via the predictive analytics, text mining, and optimization. This paper also explains the characteristics of big data, and several uses of case implementing machine learning inside the big data platform related to telco operation such as mobile fraud detection. A well-known big data processing framework such as Hadoop indicated that there is an integration with machine learning tools such as Mahout, H2O.ai, R-Hadoop components, and KNIME. The advantages of these tools are evaluated based on their scalability, ease of use and extensibility features.
Modeling of biomolecular interactions

In the beginning of the 21st century, one of the main goals of society is to increase the quality of life and maintaining the full performance and physical activity throughout the whole lifetime. This leads to extremely rapid development of all areas of human knowledge related to the study of living matter and to fast application of the obtained results for society benefit. Special attention is paid to the development of biology, medicine and pharmacy. In recent years the whole arsenal of technical and fundamental results, obtained in the other sciences – physics, chemistry, mathematics and informatics – are applied in these areas.
Influenza virosomes as a combined vaccine carrier and adjuvant system for prophylactic and therapeutic immunizations

Influenza virosomes are an efficient antigen carrier and adjuvant system that are approved for the use in human vaccines. Structurally, virosomes are spherical vesicles of approximately 150 nm in diameter, composed of a lipid membrane with integrated envelope proteins derived from influenza virus, predominantly hemagglutinin. The particle structure, together with the functions of hemagglutinin – receptor binding, pH-dependent fusion activity and immunostimulation – is responsible for the adjuvant effect of virosomes. In contrast to most other virus-like particles, virosomes are semisynthetic particles reconstituted in vitro from lipids and from virus-derived proteins. The production process has proven to be robust at industrial scale and fully compatible with Good Manufacturing Practice guidelines. At the same time, the formulation procedure is sufficiently flexible to allow modifications of the composition and structure for the intended use, including the positioning of the antigens of interest.
The Influence of Motivation And Organization Culture On Work Satisfaction And Organizational Commitment ( Study On National Society Empowerment Program In Southeast Sulawesi Province )

This study aimed to see the Effect of Motivation and Cultural Organization on the Job Satisfaction and Organizational Commitment (Study on the National Program Manager for Community Empowerment (PNPM) in Southeast Sulawesi Province). Analysis approach in this research is descriptive statistical analysis and analysis of Structural Equation Modeling (SEM). The results of this study found that relationship between variables does not affect the significance of motivation to commitment, meaning that regardless of the motivation will not result in changes in the value of commitment to the Program Administrator for Community Empowerment (PNPM) in Sulawesi southeast. This study also finds that the Organizational Culture of Commitment variable is not significant. The study also found the influence of organizational culture variable to variable indirect commitment between the Cultural Organizations of commitment through satisfaction. Indirect effect is also among the motivational variables of commitment through satisfaction variables.