Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of dietary sunflower oil on growth parameters, fatty acid profiles and expression of genes regulating growth and metabolism in the pejerrey (Odontesthes bonariensis) fry

Aquaculture fish diets usually contain an addition of fish oil to improve their nutritional value. The effect of the replacement of dietary fish oil (FO) by sunflower oil (SfO) on growth, fatty acid composition and expression of genes implicated in somatic growth, feed intake and fatty acid metabolism was studied in pejerrey fry. Fry were fed per 45 days with diets containing FO/SfO ratios of 100% FO; 50% FO:50% SfO; 20% FO:80% SfO; and 100% SfO. No differences were detected in growth and in the total per cent of saturated and monounsaturated fatty acids. Gh, ghr-I and ghr-II showed a higher mRNA expression in head and trunk of fry fed with 100% SfO diet. Expression of igf-II was higher in trunk of fry fed with 100% SfO diet compared with 100% FO diet. The Δ6-desaturase gene expression was upregulated in head and trunk of fry fed with 100% SfO diet. The nucb2/nesfatin-1 gene expression decreased in the trunk of fry with increasing dietary SfO. We conclude that the replacement of fish oil by sunflower oil in pejerrey fry feed does not affect growth and is a viable strategy to reduce production costs of this fish.
DOMESTIC RABBIT Oryctolagus cuniculus var. domestica L. AS A MODEL IN THE STUDY OF DOMESTICATION AND BIOMEDICAL RESEARCHES(review)

It is assumed that domestication is a unique form of symbiosis between humans and domesticated species that form a common habitat niche (M.A. Zeder, 2012). Research of symbiotic partners of such a niche allows us to accumulate information about the mechanisms of adaptation to it, including humans. In this regard, it is difficult to overestimate the importance of studying the domestic rabbit, because it has remained one of the main models in biomedical research for many decades (K.M. El-Bayomi, 2013). The unique physiological features of the rabbit explain its widespread use in the study of many human diseases. At the same time, we have not found any works that systematize current information on the fundamental biology of this domesticated species in comparison with its wild ancestral form. The purpose of this review is to summarize data on the population genetic structure (M. Carneiro, 2014; A.D. Stock, 1976), distribution of genomic elements (M. Carneiro, 2011), composition of microbiomes (M.S. G ó mez-Conde, 2009), morphometric characteristics and physiological features (S.N. Bogolyubskii, 1959) of the domestic rabbit and ancestral subspecies of the European rabbit, including those that determine the value of O. cuniculus var. domestica not only as an economically valuable species, but also as a model object in various fields of biomedicine. The presented comparative analysis allows us to identify a number of phenotypic characteristics (J.L. Hendrikse, 2007; I. Brusini, 2018; P.S. Ungar, 2010), as well as a group of molecular genetic markers of genomic DNA, differentiating the domestic rabbit from the ancestral species (M. Sparwel, 2019). Distribution of alleles of different mobile genetic elements, microsatellites, separate structural genes involved in the domestication process of domestic rabbit, can improve the efficiency of genetic re-sources management of not only this species but also other objects that are used in biomedical research, and for solving problems of selection work.
Global synchronization of fractional‐order and integer‐order N component reaction diffusion systems: Application to biochemical models

This study considers the problem of control and synchronization between fractional‐order and integer‐order, N‐components reaction‐diffusion systems with nonidentical coefficients and different nonlinear parts. The control scheme is designed using the Lyapunov direct method. The results are exemplified by two significant biochemical models, namely, the fractional‐order Lengyel‐Epstein model and the Gray‐Scott model. To illustrate the effectiveness of the proposed scheme, numerical simulations are performed in one and two space dimensions using Homotopy Analysis Method (HAM).
Dynamic Round Robin CPU Scheduling Algorithm Based on K-Means Clustering Technique

Minimizing time cost in time-shared operating system is the main aim of the researchers interested in CPU scheduling. CPU scheduling is the basic job within any operating system. Scheduling criteria (e.g., waiting time, turnaround time and number of context switches (NCS)) are used to compare CPU scheduling algorithms. Round robin (RR) is the most common preemptive scheduling policy used in time-shared operating systems. In this paper, a modified version of the RR algorithm is introduced to combine the advantageous of favor short process and low scheduling overhead of RR for the sake of minimizing average waiting time, turnaround time and NCS. The proposed work starts by clustering the processes into clusters where each cluster contains processes that are similar in attributes (e.g., CPU service period, weights and number of allocations to CPU). Every process in a cluster is assigned the same time slice depending on the weight of its cluster and its CPU service period. The authors performed comparative study of the proposed approach and popular scheduling algorithms on nine groups of processes vary in their attributes. The evaluation was measured in terms of waiting time, turnaround time, and NCS. The experiments showed that the proposed approach gives better results.
Caracterización genética y molecular de Pseudomonas Aeruginosa causante de infecciones en UCI de tres ciudades de Colombia.

Pseudomonas aeruginosa, bacteria ubicua que puede generar infecciones complicadas en pacientes hospitalarios, incrementando los índices de morbimortalidad debido al incremento de resistencia a los antimicrobianos de uso clínico, en especial los de última opción terapéutica como los carbapenémicos por la adquisición de determinantes de resistencia a través de elementos genéticos móviles principalmente. OBJETIVO: Caracterizar el perfil de resistencia y características moleculares de P. aeruginosa, aislada de pacientes adultos con diagnóstico de infección en tres unidades de cuidados intensivos en Colombia. MÉTODOS: Se analizaron pacientes con infecciones por P.aeruginosa en UCI adultos. A los aislamientos bacterianos se les determinó el perfil de susceptibilidad a 12 antibióticos y se amplificaron genes de resistencia a β-lactámicos, quinolonas, sulfonamidas y plataformas genéticas como integrón clase 1 y 2. La relación genética por medio de PFGE y MLST. RESULTADOS: En el estudio se analizaron 40 pacientes de los cuales 23(57,5%) pertenecen a una UCI en la ciudad de Pereira. Las principales fuentes de aislamiento de los microorganismos son hemocultivos 13(32,5%) y urocultivos 11(27,5%). Los perfiles de resistencia SAM-FOX y SAM-FOX-SXT se presentaron en 6(15,0%) y 4(10,0%) aislamientos respectivamente. Las β-lactamasas más frecuentes fueron de tipo blaTEM, en 8(20,0%), blaSHV 7(17.5%) y blaCTX-M 3(7.5%), carbapenemasas de tipo blaKPC-2 y blaVIM en 4(9.7%) y 3(7.5%). Los aislamientos presentan un comportamiento policlonal con 28 pulsotipos. Los aislamientos productores de KPC-2 y VIM se encuentran asociados al ST235 y ST111 respectivamente. CONCLUSIONES: las infecciones generadas en las UCI de las entidades participantes presentan gran variabilidad y con una moderada resistencia a carbapenémicos asociados a la presencia de KPC-2 y VIM asociados al clon pandémico ST235 y ST111.
Evidence from Impedance Spectroscopy that Elevated Dopamine Reduces Mitochondrial Membrane Potential

Background: Recent studies suggest that elevated dopamine concentrations reduce mitochondrial membrane potential, potentially contributing to neurological or other disorders. Changes in average membrane potential of suspended cells or organelles can be monitored in real time by measuring impedance of the suspension as a labelfree assay. Methods/Results: Here we report on measurements of frequency- and time-dependent electrical impedance of mitochondrial suspensions in the presence of various substrates, including dopamine. We find that, during succinateinduced state-2 respiration, addition of either trifluoromethoxy carbonylcyanide phenylhydrazone (FCCP), a known mitochondrial uncoupler (depolarizer), or dopamine at high concentrations cause similar increases in impedance, consistent with a drop in mitochondrial membrane potential. Conclusion: Our results provide further evidence that dopamine reduces mitochondrial membrane potential, albeit less severely than FCCP, possibly by generating free radicals that partially perforate the mitochondrial inner membrane and/or reduce activity of respiratory complexes. These results suggest that prolonged excess dopamine can impair ATP production, with possible implications in some neurological disorders and suggesting the need for care in the use of dopamine to treat Parkinson’s disease or heart failure.
On the Origin of Sequences: Computational Analysis of Somatic Hypermutation for Probabilistic Immunoglobulin Predecessor Identification

The human immune system uses complex mechanisms to generate enough antibody diversity to effectively protect against a wide array of potential antigens. These mechanisms obfuscate the germline predecessors of mature antibodies, making it difficult to produce a comprehensive model of the immune system. Interestingly, this problem also arises in the production of next-generation anti-viral software that use biomimicry to model malicious software as a recombination of attack patterns. Current methods fail to solve this problem in bicomputation because they ignore somatic hypermutation, one of the key methods of diversity generation. In this thesis, computational analysis is performed to develop a better model of somatic hypermutation, which is then used to improve antibody predecessor identification performance.
Brazilian Plant-Pollinator Interactions Network: definition of a data standard for digitization, sharing, and aggregation of plant-pollinator interaction data

Pollination is considered one of the most important processes for biodiversity conservation (Kremen 2005). Recently, the global community, by means of the Intergovernmental Platform of Biodiversity and Ecosystems Services (IPBES 2016), and also, the Convention on Biological Diversity (CBD 2002) recognized the importance of plant-pollinator interactions for ecosystems functioning and sustainable agriculture. The conservation of pollination depends of information about plant-pollinator interactions covering a great diversity of functional and taxonomic groups. Studies show that successful pollination can improve the amount and the quality of plant fecundation and fruit production (Kevan and Imperatriz-Fonseca 2002). However, the success of these actions depends on the knowledge on pollinators, their conservation and interactions with plants and the environment. In order to conserve and manage it, more information needs to be captured about plant-pollinator interactions. ‡ ‡ § | ¶
Korotnevella novazelandica n. sp. (Amoebozoa, Discosea, Dactylopodida) - a new freshwater amoeba with unusual combination of scales

A new freshwater species of naked lobose amoebae, Korotnevella novazelandica n. sp. (Amoebozoa, Discosea, Flabellinia, Dactylopodida), from New Zealand was studied and described. This species has sombrero-shaped as well as dish-shaped scales, a combination previously not known in Korotnevella. Phylogenetic analysis based on 18S rRNA gene placed it in a clade along with Korotnevella species possessing uniform sombrero-shaped scales: K. pelagolacustris, K. jeppesenii and K. fousta. At the level of light microscopy, K. novazelandica lacks clear distinctions from the above-mentioned species, but it could be easily distinguished from them in electron microscopy by the presence of dish-shaped scales. The presence of dish-shaped scales may be considered as a primitive character for the K. pelagolacustris + K. jeppesenii + K. fousta + K. novazelandica clade, which were secondarily lost in the most of species in this clade. The sombrero-shaped scales could have evolved from basket scales or developed de novo after the loss of basket scales.
Molecular characteristics and physiological roles of Na+–K+–Cl− cotransporter 2

Na+–K+–Cl− cotransporter 2 (NKCC2; SLC12A1) is an integral membrane protein that comes as three splice variants and mediates the cotranslocation of Na+, K+, and Cl− ions through the apical membrane of the thick ascending loop of Henle (TALH). In doing so, and through the involvement of other ion transport systems, it allows this nephron segment to reclaim a large fraction of the ultrafiltered Na+, Cl−, Ca2+, Mg2+, and HCO3− loads. The functional relevance of NKCC2 in human is illustrated by the many abnormalities that result from the inactivation of this transport system through the use of loop diuretics or in the setting of inherited disorders. The following presentation aims at discussing the physiological roles and molecular characteristics of Na+–K+–Cl− cotransport in the TALH and those of the individual NKCC2 splice variants more specifically. Many of the historical and recent data that have emerged from the experiments conducted will be outlined and their larger meaning will also be placed into perspective with the aid of various hypotheses.
The Effect of Positive Thinking Training on Different Dimensions of Quality of Life of Hemodialysis Patients: A Randomized Controlled Clinical Trial

Background: Nowadays, the quality of life of hemodialysis patients has decreased, which doubled the need for educational interventions. Objectives: The current study investigated the effect of positive thinking training on different dimensions of quality of life of hemodialysis patients. Methods: This is a controlled clinical trial study conducted on 70 hemodialysis patients in Fasa, Fars province, in 2019. The patients were selected using the simple sampling method. Then, they were divided into two groups of intervention (n = 35) and control (n = 35). After obtaining informed consent, the researchers asked the participants to complete the SF-36 Quality of Life Questionnaire. The intervention group was trained positive thinking skills in 8 workshop sessions; each lasted for 90 minutes. Data were analyzed using SPSS version 20. To analyze the data, statistical tests such as chi-square, Kolmogorov-Smirnov, independent, and t-test were used. Results: The mean and standard deviation of the patients’ quality of life in the intervention group increased from 35.95 ± 10.07 to 55.98 ± 11.71 (P < 0.001). The changes in patients’ quality of life before and after the intervention were also assessed in 8 dimensions, which showed that the quality of life of the patients did not change significantly in terms of physical function (P = 0.42) and physical pain (P = 0.62), but for other dimensions, it was significantly increased (P < 0.001). Conclusions: Positive thinking training improved the quality of life of hemodialysis patients, particularly in the dimensions of the emotional role, emotional health, energy and vitality, social performance, and general health is recommended.
Genetic context and proliferation determine contrasting patterns of copy number amplification and loss for 5S and 45S ribosomal DNA arrays in cancer

The multicopy 45S ribosomal DNA (45S rDNA) array gives origin to the nucleolus, the first discovered nuclear organelle, site of Poll I 45S rRNA transcription and key regulator of cellular metabolism, DNA repair response, genome stability, and global epigenetic states. The multicopy 5S ribosomal DNA array (5S rDNA) is located on a separate chromosome, encodes the 5S rRNA transcribed by Pol III, and exhibits concerted copy number variation (cCNV) with the 45S rDNA array in human blood. Here we combined genomic data from >700 tumors and normal tissues to provide a portrait of ribosomal DNA variation in human tissues and cancers of diverse mutational signatures. We show that most cancers undergo coupled 5S rDNA array amplification and 45S rDNA loss, with abundant inter-individual variation in rDNA copy number of both arrays, and concerted modulation of 5S-45S copy number in some but not all tissues. Analysis of genetic context revealed associations between the presence of specific somatic alterations, such as P53 mutations in stomach and lung adenocarcinomas, and coupled 5S gain / 45S loss. Finally, we show that increased proliferation rates along cancer lineages can partially explain contrasting copy number changes in the 5S and 45S rDNA arrays. We suggest that 5S rDNA amplification facilitates increased ribosomal synthesis in cancer, whereas 45S rDNA loss emerges as a byproduct of transcription-replication conflict in highly proliferating tumor cells. Our results highlight the tissue- specificity of concerted copy number variation and uncover contrasting changes in 5S and 45S rDNA copy number along rapidly proliferating cell lineages. Lay Summary The 45S and 5S ribosomal DNA (rDNA) arrays contain hundreds of rDNA copies, with substantial variability across individuals and species. Although physically unlinked, both arrays exhibit concerted copy number variation. However, whether concerted copy number is universally observed across all tissues is unknown. It also remains unknown if rDNA copy number may vary in tissues and cancer lineages. Here we showed that most cancers undergo coupled 5S rDNA array amplification and 45S rDNA loss, and concerted 5S-45S copy number variation in some but not all tissues. The coupled 5S amplification and 45S loss is associated with the presence of certain somatic genetic variations, as well as increased cancerous cell proliferation rate. Our research highlights the tissue- specificity of concerted copy number variation and uncover contrasting changes in rDNA copy number along rapidly proliferating cell lineages. Our observations raise the prospects of using 5S and 45S ribosomal DNA states as indicators of cancer status and targets in new strategies for cancer therapy.
Gut Microbiota and Obesity

The human gut hosts more than 100 trillion microorganisms, encompassing thousands of species. In adults, Bacteroidetes and Firmicutes are the most prevalent phyla. Experimental data in animal and observational studies in obese patients suggest that obesity is associated with substantial changes in the composition and metabolic function of the gut microbiota. The initial findings linked obesity with the decreased relative proportion of Bacteroidetes to Firmicutes. There are some authors who suggest that probiotics and prebiotics can modulate obesity-host metabolism in obesity and obesity-related disorders.
Analysis of Wave Characteristics along the Coast of Bangladesh Using a Coupled Wave-Hydrodynamic Delft3D Model of the Bay of Bengal

Bangladesh has a unique geophysical location at the northern apex of the Bay of Bengal. Waves originating in the Indian Ocean, are constantly travelling up the bay area and interacting with the Bangladesh coastlands. In order to estimate the major wave properties required for coastal engineering purposes, a 2D coupled Wave-Hydrodynamic model of the greater bay area was developed in this study, using the Delft3D modeling suite. The model was simulated for a year and from the model outputs, significant wave height was primarily assessed at multiple locations along the Bangladesh coastline. Considerable spatial variation was observed in the wave parameters, along the whole coast at different locations, with the south-eastern coastal region showing high trends of wave height; whereas in the deltaic south-western, and south-central zones, wave heights were rather moderate. Strong seasonal variation was also observed for the different parameters, as both wave heights and depth-average current velocity were very high during the wet monsoon season, compared to the lean winter period. The results of this study is expected to provide a reasonably sound characterization of the wave spectrum along the coastline of Bangladesh.
Application of an Improved Synthetical Semantic Similarity Method in Water Knowledge Graph

In order to integrate different kinds of information in the water affairs field, this paper proposes an improved comprehensive semantic similarity algorithm and applies it to the construction of water affairs ontology. In this article, the algorithm is to give the concept instance similarity algorithm and concept definition similarity algorithm appropriate weight. First, we apply the three algorithms to the concept of the local ontology of smart water, and then calculate the similarity between the concepts to judge the similarity between the concepts to merge the smart water data, and finally compare the similarities of the three algorithms Degree value and calculation and comparison of three similarity variance values prove the effectiveness of the method. It can be seen from the experimental results that the variance of the comprehensive similarity calculation method is smaller than that of the other two methods, and it is easier to determine the similarity between two concepts.
A hierarchical mixed effect hurdle model for spatiotemporal count data and its application to identifying factors impacting health professional shortages

Count data are common in many fields such as public health. Hurdle models have been developed to model count data when the zero count could be either inflated or deflated. However, when data are repeatedly collected over time and spatially correlated, it is very challenging to model the data appropriately. For example, to study health professional shortage areas, the number of primary care physicians along with other demographic characteristics are collected at the county level in the USA and over different years. Since the data are repeatedly collected over time, counties are nested within the state, and adjacent counties are geographically correlated, the dependence structure of the data is very complex. We develop a Bayesian hurdle model with multilayered random effects to incorporate this complex structure. We use a time‐varying random effect for each state to capture the time effect at the state level, and a temporal thin plate spline to capture the spatiotemporal correlation across different counties. We use STAN to obtain samples for inference from the posterior distribution. By using the model proposed, we can identify the important factors which impact health professional shortage areas. Simulation studies also confirm the effectiveness of the model.
PERGESERAN PERILAKU KONSUMEN DALAM MINAT BELI ULANG BERDASAR PRODUK WEBSITE (ANALISIS PERUBAHAN MODEL BISNIS TERHADAP PILIHAN KONSUMEN)

This paper discusses the change in business models that shift to the 4.0-based model in which newspapers which are the object of research change their product platforms from paper to websites at PT. Ambon Press Intermedia. The variables studied are the product and its effect on consumer behavior in using the value obtained which is reflected in the variable repurchase interest. The results showed that there was a significant relationship between information richness (richness of content), reliability of information (reliability of Content) and the appearance of the website (interface of website) on the behavior (Behavior) to consume sustainably. Keywords: e-products, repurchase interests, consumer behavior