Miracle-dz/UniFAR-FTUs huggingface dataset:
Geographical variation in colour of female threespine stickleback (Gasterosteus aculeatus)

The ecological multifunctionality of colour often results in multiple selective pressures operating on a single trait. Most research on colour evolution focuses on males because they are the most conspicuous sex in most species. This bias can limit inferences about the ecological drivers of colour evolution. For example, little is known about population divergence in colour of female threespine stickleback (Gasterosteus aculeatus), which is among the most intensively-studied model vertebrates in evolution, ecology, and behaviour. In contrast, the evolution and ecology of colour in male stickleback has received considerable attention. One aspect of female colouration that is lacking previous research is non-ornamental body colour. Non-ornamental colour can play defensive and social roles, and indicate other aspects of female stickleback ecology. To remedy this knowledge gap, we measured the colour and brightness of one dorsal and one ventral lateral area on female stickleback from nine lake populations on Vancouver Island. We found that lake populations varied in overall colour brightness and dorso-ventral contrast. In addition, we found that female brightness increased with lake size, indicating potential ecological drivers of these colour differences. Our results demonstrate that there is substantial scope for future research on female colour diversification, which has been overlooked because past researchers focused on dramatic male nuptial colours.
[COMPARISON OF HEALING RESULTS BETWEEN TIBIAL NERVE AND COMMON PERONEAL NERVE AFTER SCIATIC NERVE INJURY REPAIR IN RHESUS MONKEY].

OBJECTIVE To investigate the regularity of myelin degeneration and regeneration and the difference of axonal density between tibial nerve and common peroneal nerve after sciatic nerve injury repair in rhesue monkey. METHODS Nine adult rhesue monkeys (male or female, weighing 3.5-4.5 kg) were selected to establish the model of rat sciatic nerve transaction injury. The tibial nerve and common peroneal nerve of 5 mm in length were harvested at 5 mm from injury site as controls in 3 monkeys; the distal tibial nerve and common peroneal nerve were repaired with 9-0 suture immediately in the other 6 monkeys. And the gross observation and neural electrophysiological examination were performed at 3 and 8 weeks after repair respectively. Then, distal tibial nerve and common peroneal nerve at anastomotic site were harvested to observe the myelin sheath changes, and to calculate the number of axon counts and axonal density by staining with Luxol Fast Blue. RESULTS Atrophy of the lower limb muscle and various degrees of plantar ulcer were observed. Gross observation showed nerve enlargement at anastomosis site, the peripheral connective tissue hyperplasia, and obvious adhesion. The compound muscle action potential (CMAP) of tibial nerve and common peroneal nerve could not be detected at 3 weeks; the CMAP amplitude of common peroneal nerve was less than that of the tibial nerve at 8 weeks. Different degrees of axonal degeneration was shown in the tibial nerve and common peroneal nerve, especially in the common peroneal nerve. The average axonal density of common peroneal nerve was lower than that of tibial nerve at 3 weeks (13.2% vs. 44.5%) and at 8 weeks (10.3% vs. 35.3%) after repair. CONCLUSIONS The regeneration of tibial nerve is better and faster than that of common peroneal nerve, and gastrocnemius muscle CMAP recovers quicker, and amplitude is higher, which is the reason of better recovery of tibial nerve.
On the Application of Network Slicing for 5G-V2X

Ultra-reliable vehicle-to-everything (V2X) communication is essential for enabling the next generation of intelligent vehicles. V2X communication refers to the exchange of information between vehicle and infrastructure (V2I) or between vehicles (V2V). Network slicing is one of the promising technologies for the next generation of connected devices, creating several logical networks on a common and programmable physical infrastructure. Following this idea, we propose a network slicing based communication model for vehicular networks. In this paper, we have modelled a multi-lane highway scenario with vehicles having heterogeneous traffic requirements. Autonomous driving slice (exchanges safety messages) and infotainment slice (provides video stream) are the two logical slices created on a common infrastructure. In addition, a relaying approach is utilized to improve the performance of low signal-to-interferenceplus-noise-ratio (SINR) video streaming vehicles. These low SINR vehicles are served by other infotainment vehicles, which have high quality V2V and V2I link and are not serving as autonomous driving slice access point. An extensive Long Term Evolution Advanced (LTE-A) system level simulator is used to evaluate the performance of the proposed method, in which it is shown that the proposed network slicing approach increases the packet reception ratio (PRR) from 31.15% to 99.47%.
Larvicidal Potential of Commiphora swynnertonii ( Burtt ) Stem Bark Extracts against Anopheles gambiae ss , Culex quinquefasciatus Say and Aedes aegypti L

Petroleum ether, ethyl acetate and methanol stem bark extracts of Commiphora swynnertonii were evaluated for larvicidal potential against laboratory reared late third stage instar of mosquito namely, Anopheles gambiae ss Gile, Culex quinquefasciatus Say and Aedes aegypti L. The WHO methodology was adopted with minor modification using methanol extract with concentrations ranged from 25-300μg/mL and ethyl acetate and petroleum ether extracts with concentrations ranged from 5-50μg/mL. The activity was time and dose dependent where, ethyl acetate extract revealed higher larvicidal activity with LC50 ranged from 14.6395-3. 9455μg/mL, 2 5 . 1 0 9 6 5 . 3 4 4 2 μg/mL, 27.0405-8.4829 μg/mL for Aedes aegypti, Culex quinquefasciatus, and Anopheles gambiae at 24h, 48h, and 72h of exposure respectively. Among the three species of mosquito larvae tested, Anopheles gambiae was found to be relatively resistant to extracts followed by Culex quinquefasciatus and the weakest was Aedes aegypti. These results validate use of Commiphora swynnertonii as a potential botanical larvicidal agent in controlling mosquitoes and the spread of mosquito borne diseases.
Cardiac Hypertrophy is Positively Regulated by MicroRNA-24 in Rats

Background: MicroRNA-24 (miR-24) plays an important role in heart failure by reducing the efficiency of myocardial excitation-contraction coupling. Prolonged cardiac hypertrophy may lead to heart failure, but little is known about the role of miR-24 in cardiac hypertrophy. This study aimed to preliminarily investigate the function of miR-24 and its mechanisms in cardiac hypertrophy. Methods: Twelve Sprague-Dawley rats with a body weight of 50 ± 5 g were recruited and randomly divided into two groups: a transverse aortic constriction (TAC) group and a sham surgery group. Hypertrophy index was measured and calculated by echocardiography and hematoxylin and eosin staining. TargetScans algorithm-based prediction was used to search for the targets of miR-24, which was subsequently confirmed by a real-time polymerase chain reaction and luciferase assay. Immunofluorescence labeling was used to measure the cell surface area, and 3H-leucine incorporation was used to detect the synthesis of total protein in neonatal rat cardiac myocytes (NRCMs) with the overexpression of miR-24. In addition, flow cytometry was performed to observe the alteration in the cell cycle. Statistical analysis was carried out with GraphPad Prism v5.0 and SPSS 19.0. A two-sided P < 0.05 was considered as the threshold for significance. Results: The expression of miR-24 was abnormally increased in TAC rat cardiac tissue (t = −2.938, P < 0.05). TargetScans algorithm-based prediction demonstrated that CDKN1B (p27, Kip1), a cell cycle regulator, was a putative target of miR-24, and was confirmed by luciferase assay. The expression of p27 was decreased in TAC rat cardiac tissue (t = 2.896, P < 0.05). The overexpression of miR-24 in NRCMs led to the decreased expression of p27 (t = 4.400, P < 0.01), and decreased G0/G1 arrest in cell cycle and cardiomyocyte hypertrophy. Conclusion: MiR-24 promotes cardiac hypertrophy partly by affecting the cell cycle through down-regulation of p27 expression.
The use of an Ossis custom 3D-printed tri-flanged acetabular implant for major bone loss: minimum 2-year follow-up

Introduction: Custom 3D-printed acetabular implants are a new technology used in hip surgery with ever-increasing frequency. They offer patient-specific implants to optimise filling of bone defects and implant-bone contact, without the need for excessive bone resection. Methods: This is a retrospective cohort study of 46 consecutive patients who underwent an Ossis unilateral custom 3D-printed acetabular implant. Clinical (Oxford Hip Score OHS-60), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Harris Hip Score (HHS) and radiological (restoration of biomechanical hip centre, osteointegration, wear, heterotrophic ossification) results were assessed. Results: Patient mean age was 68 years and follow-up was 38 months (minimum 24 months). 10 patients were excluded from the outcome analysis; 2 patients died, 1 required revision for deep infection and 7 were lost to follow-up. Of the 36 patients included, 21 had severe osteolysis. 7 were revised for infection, 3 for tumoural defects, 3 for metallosis, 1 for dysplasia and 1 for trauma (Paprosky 2a [n=6], 2b [n=2], 2c [n=5], 3a [n=6], 3b [n=11], pelvic dissociation [n=6]). OHS significantly improved postoperatively (16-8-48.4 p=0.027). Postoperative functional scores were good (WOMAC 98; HHS 79). The biomechanical hip centre was restored in all patients. 1 patient had early implant migration with subsequent stabilisation. 2 patients had radiographs concerning for failure of osteointegration. 1 patient had recurrent dislocations. Conclusions: The mid-term results of the Ossis custom 3D-printed tri-flanged acetabular implant for the management of severe acetabular defects are encouraging. The improvement in functional scores and radiographic outcomes are comparable to similar designs. In addition, no cases have required revision for aseptic loosening.
Association of SNP and STR polymorphisms of insulin-like growth factor 2 receptor (IGF2R) gene with milk traits in Holstein-Friesian cows

The objective of the study reported in this Research Communication was to investigate the association of polymorphisms in the insulin-like growth factor receptor 2 (IGF2R) gene with milk traits in 283 Polish Holstein-Friesian (PHF) cows from the IGAB PAS farm in Jastrzębiec. IGF2R regulates the availability of biologically active IGF2 which is considered as a genetic marker for milk or meat production in farm animals. Two novel genetic polymorphisms were identified in the bovine IGF2R gene: a polymorphic TG-repeat in intron 23 (g.72389 (TG)15-67), and a g.72479 G > A SNP RFLP-StyI in exon 24. The following milk traits were investigated: milk yield, protein and fat yield, SCC and lactose content. To determine the influence of the IGF2R STR and SNP genotypes on the milk traits, we used the AI-REML (average information restricted maximum likelihood) method with repeatability, multi-trait animal model based on test-day information using DMU package. Statistical analysis revealed that the G/A genotype (P ≤ 0·01) was associated with milk and protein yield, lactose content and somatic cell count (SCC) in Polish HF cows. TGn (29/22, 28/29, 28/22, 28/28) genotypes were associated with high values for milk, (28/22, 28/23) with protein and fat yield, (25/20) with lactose content, and (29/33, 28/28) with low SCC. We suggest that the IGF2R gene polymorphisms could be useful genetic markers for dairy production traits in cattle.
Mechanical Behavior Optimization of Chitosan Extracted from Shrimp Shells as a Sustainable Material for Shopping Bags

The use of biodegradable materials for shopping bag production, and other products made from plastics, has recently been an object of intense research—with the aim of reducing the environmental burdens given by conventional materials. Chitosan is a potential material because of its biocompatibility, degradability, and non-toxicity. It is a semi-natural biopolymeric material produced by the deacetylation of chitin, which is the second most abundant natural biopolymer (after cellulose). Chitin is found in the exoskeleton of insects, marine crustaceans, and the cell walls of certain fungi and algae. The raw materials most abundantly available are the shells of crab, shrimp, and prawn. Hence, in this study chitosan was selected as one of the main components of biodegradable materials used for shopping bag production. Firstly, chitin was extracted from shrimp shell waste and then converted to chitosan. The chitosan was next ground to a powder. Although, currently, polyethylene bags are prepared by blown extrusion, in this preliminary research the chitosan powder was dissolved in a solvent and the films were cast. Composite films with several fillers were used as a reinforcement at different dosages to optimize mechanical properties, which have been assessed using tensile tests. These results were compared with those of conventional polyethylene bags used in Egypt. Overall, the chitosan films were found to have a lower ductility but appeared to be strong enough to fulfill shopping bag functions. The addition of fillers, such as chitin whiskers and rice straw, enhanced the mechanical properties of chitosan films, while the addition of chitin worsened overall mechanical behavior.
Multi-Objective Influence Diagrams with Possibly Optimal Policies

The formalism of multi-objective influence diagrams has recently been developed for modeling and solving sequential decision problems under uncertainty and multiple objectives. Since utility values representing the decision maker's preferences are only partially ordered (e.g., by the Pareto order) we no longer have a unique maximal value of expected utility, but a set of them. Computing the set of maximal values of expected utility and the corresponding policies can be computationally very challenging. In this paper, we consider alternative notions of optimality, one of the most important one being the notion of possibly optimal, namely optimal in at least one scenario compatible with the inter-objective tradeoffs. We develop a variable elimination algorithm for computing the set of possibly optimal expected utility values, prove formally its correctness, and compare variants of the algorithm experimentally.
Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection

The opportunistic fungal pathogen Candida albicans frequently causes diseases such as oropharyngeal candidiasis (OPC) in immunocompromised individuals. Although it is well appreciated that the cytokine IL-17 is crucial for protective immunity against OPC, the cellular source and the regulation of this cytokine during infection are still a matter of debate. Here, we directly visualized IL-17 production in the tongue of experimentally infected mice, thereby demonstrating that this key cytokine is expressed by three complementary subsets of CD90+ leukocytes: RAG-dependent αβ and γδ T cells, as well as RAG-independent ILCs. To determine the regulation of IL-17 production at the onset of OPC, we investigated in detail the myeloid compartment of the tongue and found a heterogeneous and dynamic mononuclear phagocyte (MNP) network in the infected tongue that consists of Zbtb46-Langerin- macrophages, Zbtb46+Langerin+ dendritic cells (DCs) and Ly6C+ inflammatory monocytes. Of those, the Langerin+ DC population stands out by its unique capacity to co-produce the cytokines IL-1β, IL-6 and IL-23, all of which promote IL-17 induction in response to C. albicans in the oral mucosa. The critical role of Langerin+ DCs for the innate IL-17 response was confirmed by depletion of this cellular subset in vivo, which compromised IL-17 induction during OPC. In conclusion, our work revealed key regulatory factors and their cellular sources of innate IL-17-dependent antifungal immunity in the oral mucosa.
Latency-conscious dataflow reconfiguration

We propose a prototype incremental data migration mechanism for stateful distributed data-parallel dataflow engines with latency objectives. When compared to existing scaling mechanisms, our prototype has the following differentiating characteristics: (i) the mechanism provides tunable granularity for avoiding latency spikes, (ii) reconfigurations can be prepared ahead of time to avoid runtime coordination, and (iii) the implementation only relies on existing dataflow APIs and need not require system modifications. We demonstrate our proposal on example computations with varying amounts of state that needs to be migrated, which is a non-trivial task for systems like Dhalion and Flink. Our implementation, prototyped on Timely Dataflow, provides a scalable stateful operator template compatible with existing APIs that carefully reorganizes data to minimize migration overhead. Compared to naïve approaches we reduce service latencies by orders of magnitude.
Preliminary report of explorations in Nebraska and Dakota, in the years 1855-'56-'57, by Lieut. G.K. Warren, Topographical Engineers ...

The dallaspinballproject.com is your search engine for PDF files. Platform is a high quality resource for free Books books.Give books away. Get books you want. You can easily search by the title, author and subject.Platform dallaspinballproject.com is a volunteer effort to create and share ePub online.If you're looking for a wide variety of books in various categories, check out this site. Take some advice and get your free ebooks in EPUB or MOBI format. They are a lot nicer to read. There are a lot of them available without having to go to pirate websites.
Drugs in the treatment of obesity: sibutramine, orlistat and rimonabant

Abstract Background Modification of lifestyle is the main therapeutical approach in the treatment of obesity, but use to fail on long terms of time. Addition of anti-obesity drugs allows keeping the weight loss during years and improving obesity-related comorbidities. Methods This review is an actualisation on efficacy, safety and tolerability of the approved drugs on the long-term treatment of obesity (orlistat and sibutramine). New indications and effects of their use far beyond the weight loss are as well commented. Finally, potential benefits of the administration of CB1 antagonist rimonabant on the weight loss and cardiometabolic risk factors are analysed in detail. Discussion A decade of experience on the use of orlistat and sibutramine has demonstrated their higher efficacy on the weight loss when compared to placebo either on adult or teenage population as well as safety and tolerability on long-term administration. Beneficial effects on the lipid profile, glycosilated haemoglobin on diabetic patients, blood pressure and levels of inflammatory cytokines, contribute to decrease the cardiovascular risk on obese patients. Phase III clinical trials using rimonabant show additional benefits to the expected weight loss, mainly reducing visceral fat and cardiometabolic risk factors. Conclusion Pharmacological treatment of obesity must be considered as a therapeutical tool that has to be used together with long-term lifestyle changes, contributing to the body weight reduction as well as to the improvement of the cardiometabolic risk related to obesity.
Use of Intracardiac Echocardiography in Interventional Cardiology: Working With the Anatomy Rather Than Fighting It

The indications for catheter-based structural and electrophysiological procedures have recently expanded to more complex scenarios, in which an accurate definition of the variable individual cardiac anatomy is key to obtain optimal results. Intracardiac echocardiography (ICE) is a unique imaging modality able to provide high-resolution real-time visualization of cardiac structures, continuous monitoring of catheter location within the heart, and early recognition of procedural complications, such as pericardial effusion or thrombus formation. Additional benefits are excellent patient tolerance, reduction of fluoroscopy time, and lack of need for general anesthesia or a second operator. For these reasons, ICE has largely replaced transesophageal echocardiography as ideal imaging modality for guiding certain procedures, such as atrial septal defect closure and catheter ablation of cardiac arrhythmias, and has an emerging role in others, including mitral valvuloplasty, transcatheter aortic valve replacement, and left atrial appendage closure. In electrophysiology procedures, ICE allows integration of real-time images with electroanatomic maps; it has a role in assessment of arrhythmogenic substrate, and it is particularly useful for mapping structures that are not visualized by fluoroscopy, such as the interatrial or interventricular septum, papillary muscles, and intracavitary muscular ridges. Most recently, a three-dimensional (3D) volumetric ICE system has also been developed, with potential for greater anatomic information and a promising role in structural interventions. In this state-of-the-art review, we provide guidance on how to conduct a comprehensive ICE survey and summarize the main applications of ICE in a variety of structural and electrophysiology procedures.
1 Strain ratio as a quantification tool in strain imaging 2

16 1) Background: Ultrasound-based strain imaging is now available in several ultrasound (US) 17 scanners. Strain ratio (SR) can be used to quantify strain recorded simultaneously in two different 18 user-selected areas, ideally exposed to the same amount of stress. The aim of this study was to 19 evaluate SR variability when assessed in an in-vitro setup with a tissue-mimicking phantom, on 20 resected tissue samples and in live tissue scanning with endoscopic applications. 2) Material and 21 methods: Retrospective analysis of SR for quantification of elastic contrasts in a tissue-mimicking 22 phantom containing four homogenous inclusions, in 38 resected bowel wall lesions and in 48 focal 23 pancreatic lesions examined in vivo. Median SR and the inter-quartile range (IQR) was calculated 24 on all external and endoscopic US-applications. The IQR/median provides a measure of the SR 25 variability focusing on the two percentiles of the data closest to the median value. 3) Results: The 26 overall variability of SR was lowest in a tissue-mimicking phantom (mean QR/median SR: 0.07). In 27 resected bowel wall lesions representing adenomas, adenocarcinomas or Crohn lesions, the 28 variability increased (mean IQR/Median: 0.62). During an endoscopic examination of focal 29 pancreatic lesions in vivo, the variability increased further (mean IQR/Median: 2.04). 4) Conclusion: 30 SR variability increased when assessed on different targets with growing heterogeneity and 31 biological variability as one moved from homogeneous media to live tissues and endoscopic 32 application. This may indicate a limitation for the accuracy SR evaluation in clinical applications. 33