Miracle-dz/UniFAR-FTUs huggingface dataset:
A systematic review investigating the use of Twitter and Facebook in university-based healthcare education

Purpose – The purpose of this paper is to evaluate the use, attitudes and perceptions of both teachers and students towards social media platforms (Facebook and Twitter) in healthcare higher education practice. Design/methodology/approach – Systematic literature review. A search of published and unpublished databases was conducted from January 2000 to January 2013. Data were synthesised through a narrative approach. All included studies were critically appraised using Critical Appraisal Skills Programme appraisal tools. Findings – From a total of 876 papers, 16 publications met the eligibility criteria. The review papers were largely of moderate methodological quality. The results indicated that Facebook and Twitter are perceived as potentially useful adjuncts in healthcare higher education practice. Their use as part of a “blended” approach to classroom teaching has been employed to enhance communication and increase accessibility of students to real-world practices and expertise. Whilst students perceiv.
Adenitis tuberculosa inguinal. Reporte de un caso

La presencia de crecimientos ganglionares asintomaticos vislumbra diagnosticos diferenciales que el medico clinico enfrenta con preocupacion. Se presenta el caso clinico de un preescolar masculino procedente del medio rural con linfadenopatia inguinal derecha, a quien se le diagnostico adenitis tuberculosa y se le trato con rifampicina e isoniacida. El diagnostico se realizo mediante la aplicacion de un algoritmo diagnostico de adenopatias inguinal, modificado por los autores. Se revisaron los contactos intradomiciliarios y ocasionales resultando todos baciliferos negativos razon por la cual se presume que el agente infeccioso provino del consumo de productos lacteos contaminados con micobacterias.
Représentations du cannabis des futurs acteurs de prévention en formation

En France, le nombre d’utilisateurs de cannabis a double au cours des dix dernieres annees. Les groupes les plus touches sont les jeunes adultes âges de 18-25 ans poursuivant leurs etudes. L’etude porte sur 300 personnes en formation initiale (79 professeurs d’ecoles, 135 infirmieres et 86 travailleurs sociaux), qui, en tant qu’educateurs de sante potentiels, ont ete soumises a une version adaptee de l’enquete EROPP (Enquete sur les Representations, les Opinions et les Perceptions des substances Psycho-actives). Les resultats ont ete compares a ceux de l’enquete en population generale entreprise en 2002. Nous avons analyse les differences entre le groupe test et la population generale ainsi qu’entre les differents types d’etudiants en analyse bi-variee. Les utilisateurs de cannabis ont ete egalement compares aux non-utilisateurs. Les resultats montrent une consommation excessive de cannabis dans le groupe d’etude compare a la population generale particulierement chez les hommes que ce soit dans l’experimentation ou actuellement. Les specificites de chaque groupe sont analysees et les resultats sont discutes a la lumiere du role potentiel du groupe d’etude dans l’education sanitaire.
How left behind are rural parents of migrant children? Evidence from Thailand

ABSTRACT The consequences of adult children's migration from rural areas for older parents who remain behind are keenly debated. While the mass media and international advocacy organisations favour an ‘alarmist’ view of desertion, the academic literature makes more sanguine assessments using the ‘household strategy’ and ‘modified extended family’ perspectives. We examine the relationship between the migration of adult children and various dimensions of older parents' wellbeing in Thailand using evidence from a survey that focused on the issues. The results provide little support for the alarmist view, but instead suggest that parents and adult children adapt to the social and economic changes associated with development in ways not necessarily detrimental to intergenerational relations. The migration of children, especially to urban areas, often benefits parents' material support while the recent spread of cell phones has radically increased their ability to maintain social contact. Nevertheless, changing living arrangements through increased migration and the smaller family sizes of the youngest age groups of older people pose serious challenges for aspects of filial support, especially at advanced ages when chronic illness and frailty require long-term personal care. Dealing with this emerging situation in a context of social, economic and technological change is among the most critical issues facing those concerned with the implications of rapid population ageing in Thailand and elsewhere.
Use of low-dose prothrombin complex concentrate before lumbar puncture.

PURPOSE The use of an off-label dose of four-factor prothrombin complex concentrate (PCC) for International Normalized Ratio (INR) reversal in a patient before a diagnostic lumbar puncture is reported. SUMMARY A 57-year-old, 122-kg man arrived at the hospital with a possible diagnosis of meningitis and had an INR of >3 while on warfarin therapy. The patient initiated warfarin therapy in 2009 due to recurrent deep vein thrombosis. The patient required reversal of his elevated INR in order for a lumbar puncture to be safely performed (INR must be no higher than 1.4). Multiple units of fresh frozen plasma (FFP) were administered, with a subsequent INR decrease to 1.9. Additional units of FFP were given. The patient developed respiratory decompensation due to volume overload, partially caused by the administration of multiple units of FFP. As the INR remained above 1.4 but was less than 2, an alternative dosing strategy was used. A dose of 1020 units of factor IX, equaling about 10 mg/kg based on a maximum dosing weight of 100 kg, was administered. The two vials of PCC administered each contained 510 units of factor IX. No vitamin K was given. The patient's INR, checked 30 minutes after PCC administration, was 1.3, and the lumbar puncture was performed. The lumbar puncture was completed without complication, and the patient was restarted on therapeutic anticoagulation the following day. CONCLUSION A 57-year-old patient was successfully treated with low-dose PCC to reverse an INR from 1.7 to 1.3 in order to perform a diagnostic lumbar puncture.
Clinical and functional outcomes after revascularization strategies in acute coronary syndromes

Background The ICTUS trial was a study that compared an early invasive with a selective invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome (nSTE-ACS). The study reported no difference between the strategies for frequency of death, myocardial infarction, or rehospitalization after 1 year. We did a follow-up study to assess the effects of these treatment strategies after 4 years. Methods 1200 patients with nSTE-ACS and an elevated cardiac troponin were enrolled from 42 hospitals in the Netherlands. Patients were randomly assigned either to an early invasive strategy, including early routine catheterization and revascularization where appropriate, or to a more selective invasive strategy, where catheterization was done if the patient had refractory angina or recurrent ischemia. The main endpoints for the current follow-up study were death, recurrent myocardial infarction, or rehospitalization for anginal symptoms within 3 years after randomization, and cardiovascular mortality and all-cause mortality within 4 years. Analysis was by intention-to-treat. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN82153174. Results The in-hospital revascularization rate was 76% in the early invasive group and 40% in the selective invasive group. After 3 years, the cumulative rate for the combined endpoint was 30.0% in the early invasive group compared with 26.0% in the selective invasive group (hazard ratio 1.21; 95% CI 0.97–1.50; p=0.09). Myocardial infarction was more frequent in the early invasive strategy group (106 (18.3%) vs 69 (12.3%); HR 1.61; 1.19–2.18; p=0.002). Rates of death or spontaneous myocardial infarction were not different (76 (14.3%) patients in the early invasive and 63 (11.2%) patients in the selective invasive strategy (HR 1.19; 0.86–1.67; p=0.30)). No difference in all-cause mortality (7.9% vs 7.7%; p=0.62) or cardiovascular mortality (4.5% vs 5.0%; p=0.97) was seen within 4 years. Conclusion Long-term follow-up of the ICTUS trial suggests that an early invasive strategy might not be better than a more selective invasive strategy in patients with nSTE-ACS and an elevated cardiac troponin, and implementation of either strategy might be acceptable in these patients. Long-term outcome of the ICTUS trial 25
Prevalence and antimicrobial susceptibility pattern of Extended Spectrum Beta Lactamase (ESBL) and non-ESBL producing enteric gram-negative bacteria and activity of nitrofurantoin in the era of ESBL

Background: Resistance in enteric Gram-negative bacteria is of a great concern and concise local data are lacking. Objectives: To determine prevalence and antimicrobial susceptibility pattern of Extended Spectrum Beta-Lactamase (ESBL) and non-ESBL producing enteric Gram-negative bacteria. Materials and Methods: In a descriptive study in Tehran, patients' samples have been obtained and were inoculated on blood and MacConkey agar plates at microbiology laboratory hospital, and a total of 292 Gram-negative species were isolated at Microbiology Laboratory from patients' specimens. Susceptibility pattern was determined by disk diffusion method based on Kirby-Bauer method on Mueller-Hinton agar plate. SPSS 16 software (descriptive analysis, Chi-square) was used for statistical analysis of this study. Results: Escherichia coli was the most common organism [189 (64.7%)], followed by Acinetobacter baumannii [40 (13.7%)], Pseudomonas aeruginosa [32 (11%)], Klebsiella pneumoniae [26 (8.9%)], Proteus mirabilis [4 (1.4%)], and Serratia marcescense [1 (0.3%)]. 122 (41.8%) of isolates were classified as ESBL - producers. E. coli accounted for most of the ESBL-producer bacteria, followed by K. pneumoniae. 170 (58.2%) of isolates were non-ESBL producers. All of the ESBL producer isolates were sensitive to imipenem, piperacillin-tazobactam and colistin whereas resistance to these antibiotics in the non-ESBL group was seen. The rate of resistance to nitrofurantoin in ESBL group was lower than of that in non-ESBL group. The majority of the ESBL isolates of resistant to trimethoprim-sulfamethoxazole, ciprofloxacin, the third generation cephalosprins (ceftriaxone, cefixime, and cefotaxime), gentamicin and amikacin, were sensitive to nitrofurantoin. Conclusion: Although all ESBL producer Gram-negative bacteria were sensitive to imipenem, piperacillin-tazobactam, and colistin, non-ESBL isolates showed resistant pattern. Interestingly, notable percent of mentioned resistant isolates were sensitive to nitrofurantoin.
Deconstructing the ALT-associated promyelocytic leukemia biodies

Cells in which Alternative lengthening of telomeres (ALT) is activated have been reported to contain a novel PML nuclear body (PML-NB) known as ALT-associated PML body (APB). These large, donut-shaped nuclear structures are unique to telomerase-negative cells and contain, among others, PML, telomeric DNA, the telomere binding proteins TRF1 and TRF2, MRE11 and NBS1. APBs can be correlated with ALT in that they appear when the telomere length pattern becomes characteristic of ALT positive cells and are not found in telomerase positive cell lines. The exact role of these bodies in telomere maintenance and/or protection is as yet unclear as there have been few studies carried out to determine the functional involvement of the specific components. Our study aims at the identification of the essential components of this structure and, ultimately, at studying the effect of APB alterations on telomere length and genomic stability. We began by determining the percentage of APB-positive cells within our chosen cell lines, and found that there were a higher proportion of APB positive cells than reported in the literature. In order to determine the role of PML in formation of APB, we employed RNA interference oligonucleotides directed against nuclear PML. Interestingly, decreased speckled distribution of MRE11 and TRF1 was observed in PML-depleted cells. In contrast, TRF2 was not affected, and its downregulation has no clear effect on MRE11 or TRF1 localization. TRF2 silencing results in telomere erosion, thus suggesting that in ALT cells TRF2 regulates telomere length. In addition, TRF2 depletion causes inhibition of colony formation, increased cell size, p21 upregulation and induction of genomic instability. Although in ALT cells active ATM is found at APBs, it is only following TRF2 silencing that the ATM target p53 becomes phosphorylated and activated. This study sheds new light on the role of the APB components PML and TRF2 in ALT cells.
Is fibrosis a marker for angiotensin pathway involvement in sudden cardiac death

Pulmonary pathology is the third most requent cause of sudden death in young adults, usually associated with asthma, thrombembolism, infectious respiratory disorders, or rheumatoid disorders. Many cardiovascular pathologies leading to sudden cardiac death are known to be associated with unspecific pulmonary changes. In this study we aimed to analyze the morphologic appearance of the lungs in cases of sudden death with a blank autopsy. Material and method: 89 sudden death cases with blank autopsies were selected from the National Institute of Legal Medicine database; from each a total number of 59 parameters were selected and analyzed. Results: Significant correlations were found between pulmonary fibrosis and renal glomerular fibrosis, pulmonary edema and renal interstitial fibrosis, pulmonary stasis and myocardial lipomatosis, and pulmonary fibrosis and hypoxic cardiomyocytes. Very significant correlations new identified between pulmonary and renal stasis, pulmonary edema and renal glomerular sclerosis, pulmonary fibrosis and renal interstitial fibrosis, myocardial stasis and myocardial hemorrhages. Conclusion: unspecific fibrotic pulmonary changes were found and were positively correlated with renal fibrosis. This may suggest a possible role of angiotensin pathway in some sudden deaths where the autopsy is blank or unspecific. Further studies must be conducted in this area in order to confirm this hypothesis.
Child abuse and the family court

The authors discuss whether the Family Court is equipped to manage those cases that come before it where child abuse allegations have been made. They look at the problems surrounding this matter and report on a recent research study which found that these families have many difficulties, including a history of family violence. The study challenges the community belief that false allegations of child abuse are more common in Family Court cases than in other situations.
An investigation of Western Australian pre-service primary teachers' experiences and self-efficacy in the arts

The arts are crucial in developing our multi-sensory interpretation of culture. With the introduction of the Australian National Curriculum in the arts, there is cause to reflect on teacher education courses, and pre-service teachers’ ability to deliver the new curriculum. Reflection on students’ experiences in the arts may provide insight into improving teacher education. A mixed methods study was conducted with first and fourth-year Bachelor of Education primary students at a Western Australian university, to determine students’ arts experiences prior to and during the course. Fourth-year graduating students were also asked to reflect on their self-efficacy to teach the arts based on the course. Data were analysed using descriptive statistics, and interview observations are presented to contextualise these findings. The research emphasised the importance of building self-efficacy to support ongoing personal and professional engagement with the arts.
Contacts by Distressed Individuals to UK Parapsychology and Anomalous Experience Academic Research Units - A Retrospective Survey Looking to the Future

This paper reports on two studies motivated by concerns over contacts by distressed individuals to academic parapsychology units, and the implications of this for their mental health. In light of current research on the benefits of early identification and intervention in psychosis, a retrospective survey of records of distressed contacts to UK units and an interview study with units’ staff were undertaken. The content analysis in Study 1 characterised (demographically and clinically) this group of helpseeking individuals, and how they use parapsychological units when in distress. Study 2’s thematic analysis represented the way staff perceive and deal with such contacts. Outcomes suggest that: 1) when units declare interest in parapsychology or anomalous experiences they attract a small number of distressed individuals who may be at risk of or in first episode psychosis; 2) units are used as a first help-seeking contact or as an alternative, after engagement with mental health services; 3) staff recognise the demand, but feel currently limited in their ability to respond to these individuals’ needs; 4) this may be addressed by units establishing a procedure which: a) ensures that relevant information is reflexively understood and consistently recorded; and b) involves collaboration with clinical advisors; and 5) such a procedure may contribute to the significant reduction of distress to the individual.
Pathogenesis of Dengue Haemorrhagic Fever and Its Impact on Case Management

Plasma leakage and intrinsic coagulopathy are the pathological hall marks in dengue haemorrhagic fever (DHF). Viral virulence, infection enhancing antibodies, cytokines and chemical mediators in the setting of intense immune activation are the key players implicated in the pathogenesis of DHF; the exact nature of which is yet to be fully understood. The pathophysiological changes the attended clinical features of plasma leakage necessitate recognition of changing physiological parameters for the early recognition of plasma leakage and appropriate fluid therapy. On the other hand, the changes in the haematological indices resulting from coagulopathy can tempt the clinician to initiate other modalities of therapy. A clearer understanding of the pathogenesis of DHF and the appreciation that both of these fundamental pathological changes share common pathogenic mechanisms would facilitate the appropriateness of management decisions and the early recognition of severe disease. Thus, thrombocytopaenia, reduced fibrinogen, and prolonged partial thromboplastin time early in the disease course connoted severe disease and attended plasma leakage rather than clinical bleeding. The detection of plasma cytokine profile by a multiple bead immunoassay could also complement clinical parameters in predicting severe disease early in the disease course. Thus, MIP-β indicates good prognosis while IFN-γ portends severe disease.
Novel tumor markers in the serum of testicular germ cell cancer patients: a review

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress. com/permissions.php Current Biomarker Findings 2014:4 133–137 Current Biomarker Findings Dovepress
Achieving provider status for pharmacists.

Paul W. Abramowitz, Pharm.D. , FASHP January 2, 2013 ! [Figure][1] Achieving provider status under Section 1861 of the Social Security Act is important for the profession. It is essential to recognize pharmacists for the patient-care providers that they already are, along with other formally
Managing risks in drug therapy

In recent years, increasing attention has been focussed on medication errors as a cause of iatrogenic disease. This paper outlines the magnitude of adverse drug events and medication errors and describes the approach adopted by the Copenhagen Hospital Co-operation in order to address these problems. The Copenhagen Hospital Co-operation (H:S for short) is a public health organisation that owns and operates six hospitals serving approximately 20% of the patients in the Danish health care system. H:S is the first hospital system in Scandinavia to be accredited by the Joint Commission on the Accreditation of Healthcare Organisations (JCAHO).
The impact of the M184V substitution on drug resistance and viral fitness

Treatment of HIV/AIDS with antiretroviral therapy can result in HIV-1 drug resistance, limiting its use. Resistance mutations arise prior to therapy due to errors in HIV-1 replication, and are also spread by sexual and other modes of transmission. However, it is also generally believed that resistance is due to multiple drug mutations to any single or combination of antiretroviral agents selected during viral replication in the presence of incompletely suppressive drug regimens. In the case of protease inhibitors and most nucleoside analog reverse transcriptase inhibitors, drug resistance is due to the accumulation of mutations in the HIV-1 protease and reverse transcriptase genes respectively. However, in the case of non-nucleoside reverse transcriptase inhibitors, a single primary drug mutation is usually sufficient to abrogate antiviral activity. This is also true of certain specific mutations, such as M184V in the reverse transcriptase enzyme, resulting in resistance to the nucleoside analog, lamivudine (Epivir®, GlaxoSmithKline). However, it is thought that lamivudine may still contribute to the effectiveness of antiretroviral therapy, even after the appearance of the M184V mutation. M184V may affect sensitivity to other drugs, such as zidovudine (Retrovir®, GlaxoSmithKline), in HIV-1 variants that already contain resistance mutations to zidovudine, during concomitant treatment with lamivudine. M184V also has a positive effect on HIV-1 RT fidelity, reducing spontaneous HIV mutagenesis. Processivity of the reverse transcriptase enzyme may be affected by mutations such as M184V, and this may be a major determinant of viral replication fitness.