Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship of destructive periodontal disease to the acute-phase response.

BACKGROUND Destructive periodontal diseases have been associated with an increased risk of atherosclerotic complications; however, the potential mechanisms are yet to be defined. Inflammation plays a central role in atherosclerosis since C-reactive protein (CRP), an acute-phase protein monitored as a marker of inflammatory status, has been identified as a major risk factor for atherosclerotic complications. Recent reports that destructive periodontal diseases can increase CRP values present the possibility that the acute-phase response may link these 2 disease processes. The objective of the present investigation was to determine the effect of destructive periodontal disease status, severity, and progression on components of the acute-phase response in an urban minority population. METHODS Clinical measurements recorded included probing depth, attachment level, gingival erythema, bleeding upon probing, suppuration, and plaque. Disease progression was defined as a >2 mm loss of attachment 2 months post-baseline. Serum antibody was measured by enzyme-linked immunosorbent assay. CRP was measured using a high-sensitivity CRP (hsCRP) assay. A commercial laboratory measured serum glucose (non-fasting), albumin, cholesterol, high-density lipoprotein (HDL), triglycerides, low-density lipoprotein (LDL), and iron. RESULTS Increased serum IgG antibody to Porphyromonas gingivalis, but not to 5 other species, was associated with periodontal disease status, increased severity, and progression as were age, male gender, and smoking. Cholesterol and LDL were increased in disease, and HDL and iron were increased in health. hsCRP, glucose, and cholesterol increased with disease progression. By regression analysis, IgG antibody to P. gingivalis correlated with age, probing depth, and hsCRP, and negatively correlated with albumin and iron. By logistic regression, subjects who experienced multiple sites of disease progression and elevated antibody to P. gingivalis increased the odds ratio of hsCRP>2.08 mg/l by 14.1 and 5.6, respectively. CONCLUSION These results suggest that destructive periodontal disease and disease progression are associated with changes in serum components consistent with an acute-phase response.
The Effect of Antithymocyte Globulin on Anti–Human Leukocyte Antigen Antibody Detection Assays

Background. We evaluated the effect of antithymocyte globulin (ATG) on anti-human leukocyte antigen (HLA) antibody assays. Methods. We tested sera from six in vivo ATG-treated kidney transplant patients after measuring serum concentrations, as well as six nonsensitized sera with ATG added in vitro. T- and B-cell complement-dependent cytotoxicity (CDC), flow cytometric (FXM), and solid-phase HLA class I and II assays based on antigen-coated microspheres and enzyme-linked immunosorbent assay (ELISA) were studied. Sera were then retested after treatment to remove ATG. Results. We found that ATG affects test results differently depending on whether sera is obtained from in vivo treated patients or added in vitro. In vitro treated sera produced ATG concentration-dependent positive results for T/B CDC, FXM, and flow bead testing for HLA I/II, while the ELISA-based assay was unaffected. In vivo treated sera from ATG-treated patients produced positive test results for T CDC and T/B FXM, while the B-cell CDC crossmatch remained negative. Solid phase assays were minimally affected using in vivo treated sera. After ATG extraction, all tests became negative. Conclusion. We conclude that ATG produces positive results in anti-HLA antibody testing, and treatment to remove ATG abolishes this effect. This treatment allows ATG-treated patients to be monitored for anti-HLA antibodies.
A consideration of the impact of interactions with module effects on the direct measurement of subjective software attributes

Decision support approaches for software development frequently rely on the ability of experts to measure subjective attributes consistently on an ordinal scale. Examples include: decision approaches concerning alternative software architectures that are needed to optimise maintenance effort; approaches to achieve development goals which rely on Bayesian Belief Networks; pricing decisions for maintenance contract tendering that use direct measurement of maintainability; and pricing decisions concerning effort estimation that require measurement of 'complexity' attributes. In addition the validation of prediction systems and objective indirect measures for subjective attributes (e.g. maintainability, cohesion) require that observers can directly measure the attributes consistently. However, intuition and some anecdotal evidence suggest that during modular effort estimation there may be module effects that lead to under estimation. A Bayesian inference procedure can enable an assessment of whether the consistency of measurement of a modular attribute may be influenced by module effects. For example, whether the chance of correctly classifying a modular attribute might vary with module length. The study examines two data sets, one taken from a cohesion experiment and the other for a maintainability experiment. In so doing, evidence that module length interacts with the chance of correctly classifying maintainability and cohesion is inferred. These interactions show that it is necessary for those who undertake direct measurement of modular attributes to be made aware of the potential of unsolicited module effects to influence measurement consistency.
Content Centric Network With Label Aided User Modeling and Cellular Partition

The popularity of smart devices and the increase of access rate are switching Internet from link-centric (host-to-host) to content-centric (user-to-content). Since the primary purpose of users is to find their desired contents from the Internet, the traditional host-to-host structure will cause lots of useless traffic and decrease the network efficiency. Content-centric network (CCN) is then introduced to solve this embarrassed situation. As a new-born technology, CCN has not fully explored its potential to utilize the knowledge embedded in the contents. Hence, we propose to enhance the information extraction capability of CCN with data driving methods. Specifically, we add a label vector containing feature descriptions for each content, and then apply neural network (NN) to model users’ behavior and predict their responses to new contents. To further increase prediction accuracy and potential benefits, we group users into different cells. The behavior sets of users in a cell at different time intervals are modeled by a series of NNs. Moreover, we design a new caching policy to improve network caching efficiency. Benefits in other aspects and future research directions are also discussed. Quantitative evaluations of the proposed model and caching policy are presented in the end of this paper.
Applied Plasma Medicine

An emerging field of plasma medicine is discussed, where non-equilibrium plasmas are shown to be able to initiate, promote, control, and catalyze various complex behaviors and responses in biological systems. More importantly, it will be shown that plasma can be tuned to achieve the desired medical effect, especially in medical sterilization and treatment of different kind of skin diseases. Wound healing and tissue regeneration can be achieved following various types of plasma treatment in a multitude of wound pathologies. Non-equilibrium plasmas will be shown to be non-destructive to tissue, safe, and effective in inactivation of various parasites and foreign organisms.
A 77GHz 3.3V 4-channel transceiver in SiGe BiCMOS technology

We present a 77GHz four-channel transceiver for automotive radar applications designed in a 200GHz fT SiGe BiCMOS technology. The chip features a Tx-channel, a prescaler by 1536, and three Rx-channels. One of those Rx is in I/Q configuration. The Rx-channels show a typical conversion gain of 19dB while the NFssb is lower than 13dB at 100kHz. The VCO is based on a new topology which allows generating differential push-push outputs. It shows a tuning range larger than 8GHz. The phase noise is −74dBc/Hz at 100kHz offset. The output power is 9dBm. At a 3.3V supply, the chip consumes 533mA.
The Political Economy of Nutrition and Health Standards in Food Markets

This paper presents a general political economy model of standards. We use the model to derive political and social optima of nutrition and health standards in food markets, and to identify under which cases “understandardization” or “over-standardization” will result. The paper analyses the impact of trade and development on the political equilibrium as well as the role of the media and consumer perceptions.
Soluble P-selectin level correlates with acetylsalicylic acid but not with clopidogrel response in patients with stable coronary artery disease after a percutaneous coronary intervention

BackgroundImpaired response to dual antiplatelet therapy is associated with worse cardiovascular outcome. Besides antiplatelet effects, there is evidence that both clopidogrel and acetylsalicylic acid (ASA) have anti-inflammatory properties. However, little is known about the relationship between platelet function and inflammation under dual antiplatelet therapy in patients with stable coronary artery disease. PurposeThe purpose of the study was to investigate the correlation of platelet function with soluble (s)P-selectin and soluble (s)CD40L in patients undergoing elective percutaneous coronary intervention. Poor response to ASA and clopidogrel could lead to increased levels of inflammatory markers. MethodsA total of 148 patients were included. Eighty percent of the patients were on 100 mg ASA and all patients were clopidogrel naive. They underwent percutaneous coronary intervention and received a loading dose of 600 mg clopidogrel. Platelet function was assessed by light transmittance aggregometry (LTA) and vasodilator-stimulated phosphoprotein analysis at baseline, 24 h after loading, and after 1 month of maintenance therapy, respectively. Plasma levels of sP-selectin and sCD40L were measured. To classify low responders to clopidogrel, patients were screened for genetic variants determining clopidogrel absorption and metabolization. ResultssP-selectin levels correlated with LTA findings after stimulation with arachidonic acid (P=0.012). Further, in addition to decreased platelet reactivity observed on LTA, lower sP-selectin levels were seen in patients under ASA therapy (P=0.004). CYP2C19*2 allele carriers had a higher platelet reactivity after clopidogrel loading measured by adenosine diphosphate-induced aggregation in LTA (P=0.008) and vasodilator-stimulated phosphoprotein phosphorylation (P=0.035); however, there was no difference in the inflammatory markers. Multiple regression analysis showed that variables significantly related to sP-selectin plasma levels were sCD40L (P<0.001), LTA after stimulation with arachidonic acid (P<0.001), adenosine diphosphate (20 µmol/l, P=0.009), collagen (P<0.001), and ejection fraction (P=0.001). ConclusionsP-selectin was decreased in patients receiving ASA but did not reflect a CYP2C19*2-defined clopidogrel response. This underlines that sP-selectin is a useful marker for ASA, but not for clopidogrel response, in stable coronary artery disease.
Variability in SOI Schottky barrier MOSFETs

We study the variability of the electrical characteristics of silicon-on-insulator (SOI) SB-MOSFETs. A new method by extracting the variation of the threshold voltage from a large number of devices with different SOI thicknesses enables determining the main sources of variability and distinguishing between them. It is found that the device-to-device variability is mainly due to the inherent variation of the Schottky barrier (SB) height. An additional but smaller contribution stems from fluctuations of the SOI body thickness itself. However, scaling the SOI thickness down our measurements suggest that the SB inhomogeneity increases with decreasing tsi. Furthermore, employing dopant segregation during silicidation to realize low SB heights leads to an increase of the variability, too. Using the measured spread of PhiB we discuss on the base of simulations the influence of this variation on the on-current of SB-MOSFETs. The improved electrostatic gate control in multi-gate devices reduces the sensitivity of carrier injection on an inhomogeneous PhiB and thus suppresses the variability.
The optimal hybrid/electric ferry for the liguria Natural Parks

With this work we want to contribute to the evaluation of the effectiveness of using an electric/hybrid Ferry boat for tourist transportation in a real case. For this purpose, it is necessary to define the “optimal” systems configuration of the Ferry boat in term of engine power, energy storage and photovoltaic system sizes and also percentage of hybrid or pure electric usage. However the adjective “optimal” cannot have an absolute definition because it strongly depends on the context we are evaluating the problem and also subjective factors, not easily quantifiable, enter the evaluation of optimal system. For example, for a ferry working in marine Natural Parks like those around La Spezia harbor, operating and initial costs are important parameters to be considered, but pollution, noise and comfort are at least as much important ones. Moreover, due to the constraints given by the battery storage system (volume, weight, cost and recharge time) the hybrid/electric system of the ferry must be well targeted at the specific routes and possible stages in the transport service around the La Spezia Gulf. For that reason, we focus to the determination of an optimal hybrid ferryboat, aimed at the specific case of La Spezia. We think that the analysis here performed can be replicated to other cases and may be useful in showing the potential of these new technologies for a more sustainable boating, both from the environmental and economic point of view, while also improving the service provided to passengers, especially in terms of comfort.
Contributions and co-ordination of individual fingers in multiple finger prehension.

The contributions and co-ordination of external finger grip forces were examined during a lifting task with a precision grip using multiple fingers. The subjects (n = 10) lifted a force transducer-equipped grip apparatus. Grip force from each of the five fingers was continuously measured under different object weight (200 g, 400 g and 800 g) and surface structure (plastic and sandpaper) conditions. The effect of five-, four-, and three-finger grip modes was also examined. It was found that variation of object weight or surface friction resulted in change of the total grip force magnitude; the largest change in finger force, was that for the index finger, followed by the middle, ring, and little fingers. Percentage contribution of static grip force to the total grip force for the index, middle, ring, and little fingers was 42.0%, 27.4%, 17.6% and 12.9%, respectively. These values were fairly constant for all object weight conditions, as well as for all surface friction conditions, suggesting that all individual finger force adjustments for light loads less than 800 g are controlled comprehensively simply by using a single common scaling value. A higher surface friction provided faster lifting initiation and required lesser grip force exertion, indicating advantageous effect of a non-slippery surface over a slippery surface. The results indicate that nearly 40% force reduction can be obtained when a non-slippery surface is used. Variation in grip mode changed the total grip force, i.e., the fewer the number of fingers, the greater the total grip force. The percent value of static grip force for the index, middle, and ring fingers in the four-finger grip mode was 42.7%, 32.5%, and 24.7%, respectively, and that for the index and middle fingers in the three-finger grip mode was 43.0% and 56.9%, respectively. Therefore, the grip mode was found to influence the force contributions of the middle and ring fingers, but not of the index finger.
Towards a Model for Instrumental Mapping in Expert Musical Interaction

This paper reviews models of the ways in which performer instrumental actions can be linked to sound synthesis parameters. We analyse available literature on both acoustical instrument simulation and mapping of input devices to sound synthesis in general human-computer interaction. We further demonstrate why a more complex mapping strategy is required to maximise human performance possibilities in expert manipulation situations by showing clear measurements of user performance improvement over time. We finally discuss a general model for instrumental mapping, by separating the mapping layer into two independent parts. This model allows the expressive use of different input devices within the same architecture, or conversely, the use of different synthesis algorithms, by only changing one part of the mapping layer.
Science gone translational: the OX40 agonist story

Summary: OX40 (CD134) is a tumor necrosis factor (TNF) receptor expressed primarily on activated CD4+ and CD8+ T cells and transmits a potent costimulatory signal when engaged. OX40 is transiently expressed after T‐cell receptor engagement and is upregulated on the most recently antigen‐activated T cells within inflammatory lesions (e.g. sites of autoimmune destruction and on tumor‐infiltrating lymphocytes). Hence, it is an attractive target to modulate immune responses: OX40 blocking agents to inhibit undesirable inflammation or OX40 agonists to enhance immune responses. In regards to this review, OX40 agonists enhance anti‐tumor immunity, which leads to therapeutic effects in mouse tumor models. A team of laboratory and clinical scientists at the Providence Cancer Center has collaborated to bring the preclinical observations in cancer models from the bench to the bedside. This review describes the journey from in vitro experiments through preclinical mouse models to the successful translation of the first OX40 agonist to the clinic for the treatment of patients with cancer.
Photoinduced Chemical Dynamics of High-Spin Alkali Trimers

Nanometer-sized helium droplets, each containing about 104 helium atoms, were used as an inert substrate on which to form previously unobserved, spin-3/2 (quartet state) alkali trimers. Dispersed fluorescence measurements reveal that, upon electronic excitation, the quartet trimers undergo intersystem crossing to the doublet manifold, followed by dissociation of the doublet trimer into an atom and a covalently bound singlet dimer. As shown by this work, aggregates of spin-polarized alkali metals represent ideal species for the optical study of fundamental chemical dynamics processes including nonadiabatic spin conversion, change of bonding nature, and unimolecular dissociation.
Chronic Demyelinating Polyneuropathies

ABSTRACT Purpose of Review: This article reviews the chronic demyelinating neuropathies, with a focus on the diagnosis and treatment of immune-mediated neuropathies and the features that can help differentiate immune-mediated neuropathies from other chronic demyelinating peripheral nerve conditions. Recent Findings: Advances in clinical phenotyping and outcomes assessment have enabled neurologists to improve disease recognition, treatment, and disease monitoring. Our understanding of the immunopathogenesis of demyelinating neuropathies is evolving. Identification of new antibodies and recognition that node of Ranvier dysfunction may be an early pathogenic feature may herald further diagnostic and treatment advancements. Summary: The chronic demyelinating polyneuropathies are heterogeneous. The clinical and diagnostic features are sometimes overlapping, and the specific disorders are variable in pathogenesis, treatment, and prognosis. This heterogeneity underscores the importance of achieving diagnostic accuracy and implementing disease-specific treatment approaches.
Radiation enhancement in PCB plane using novel multi-stub inverted F antenna

In this paper, a novel printed circuit board (PCB) antenna referred to as Multi-Stub Inverted F Antenna is proposed. The proposed antenna has enhanced radiation in the plane of PCB, as compared to traditional Inverted F Antenna. The proposed Multi-Stub methodology is verified in simulation and measurement by designing antenna at 2.45 GHz, which is widely used in portable wireless consumer products. The antenna dimension is 25.3 mm × 16.0 mm with measured gain of 0.8 dBi. Gain variation of the proposed Multi-Stub antenna in the PCB plane is well within 2.8 dB, as compared to 9.2 dB variation in traditional inverted F antenna. The proposed Multi-Stub methodology can be adopted in existing PCB monopole antennas as well, to enhance their radiation, particularly in the PCB plane.
The gut as target organ for oral immunovaccination with allergen DNA: new hope for patients with anaphylactic reactions to food?

Comment The management of patients with food allergy is unsatisfactory as the mechanisms underlying these reactions are not well understood and the diagnostic means to confirm food allergy on an objective basis are limited. Consequently, the clinical relevance of food allergy in the pathogenesis of gastrointestinal diseases is largely unclear.1 2 However, epidemiological studies suggest that food allergy is common, particularly in children, and often causes fatal reactions.3 4 The treatment options are often not successful as avoiding relevant food allergens may be extremely difficult, even if they could be clearly identified, and standard immunotherapy lacks efficacy. Because of the reported severe or even fatal reactions, which seem to be mostly IgE mediated, effective prophylactic and therapeutic strategies are urgently needed.5 6 Roy et al report a new approach to the modulation of anaphylactic responses to food allergens using a murine model of peanut allergy. Susceptible strains of mice were treated orally with nanoparticles containing DNA …
Exploring the Dynamics of Culture in the Roll-out and Adoption of eCollaboration Technology: A Case Study Comparison

Implementing eCollaboration technologies implies specific organizational challenges surrounding roll-out and adoption. IT adoption literature has researched the concept of culture and the notion of fit between IT and culture. However, in the context of eCollaboration technologies, cultural fit as a possible influence factor has not been explored sufficiently. Thus, we aim at closing this gap by exploring the role of culture in the roll-out and adoption of eCollaboration technologies. We present two cases of eCollaboration technology roll-out that contrast in the extent to which the technology was adopted. The cases were analyzed from a culture perspective. Although our results confirmed the relevance of cultural fit, they also revealed additional dimensions of the concepts of culture and cultural fit that should be investigated further. Our paper contributes to a better understanding of the nature of cultural influence in the organizational roll-out and adoption of eCollaboration technologies.