Miracle-dz/UniFAR-FTUs huggingface dataset:
Modélisation de la dépendance pour des statistiques d'ordre et estimation non-paramétrique.

Dans cette these, on considere la modelisation de la loi jointe des statistiques d'ordre, c.a.d. des vecteurs aleatoires avec des composantes ordonnees presque surement. La premiere partie est dediee a la modelisation probabiliste des statistiques d'ordre d'entropie maximale a marginales fixees. Les marginales etant fixees, la caracterisation de la loi jointe revient a considerer la copule associee. Dans le Chapitre 2, on presente un resultat auxiliaire sur les copules d'entropie maximale a diagonale fixee. Une condition necessaire et suffisante est donnee pour l'existence d'une telle copule, ainsi qu'une formule explicite de sa densite et de son entropie. La solution du probleme de maximisation d'entropie pour les statistiques d'ordre a marginales fixees est presentee dans le Chapitre 3. On donne des formules explicites pour sa copule et sa densite jointe. On applique le modele obtenu pour modeliser des parametres physiques dans le Chapitre 4.Dans la deuxieme partie de la these, on etudie le probleme d'estimation non-parametrique des densites d'entropie maximale des statistiques d'ordre en distance de Kullback-Leibler. Le chapitre 5 decrit une methode d'agregation pour des densites de probabilite et des densites spectrales, basee sur une combinaison convexe de ses logarithmes, et montre des bornes optimales non-asymptotiques en deviation. Dans le Chapitre 6, on propose une methode adaptative issue d'un modele exponentiel log-additif pour estimer les densites considerees, et on demontre qu'elle atteint les vitesses connues minimax. L'application de cette methode pour estimer des dimensions des defauts est presentee dans le Chapitre 7
Inductances and Back-emf Harmonics Influence on the Torque/Speed Characteristic of Five-Phase SPM Machine

In this paper, the study of torque/speed characteristic for five-phase Surface-mounted Permanent Magnet (SPM) machine is carried out. With considering several hypothesis (linear magnetic modelling, only first and third harmonic terms in the back-emf and current spectrums), an optimization problem that aims to maximize the torque for given maximum voltage and RMS current is formulated: the optimal torque sharing among the two virtual machines (the two dq-axis subspaces) that represent the real five-phase machine is thus calculated for any mechanical speed. For an inverter and a DC voltage sized with only considering the first harmonic of back-emf and current, the problem is solved with changing the ratio between the two virtual machine back-emfs and changing the ratio between the two virtual machine inductances. The results are examined by introducing particular speed points.
Metabolic Syndrome in Childhood Predicts Adult Cardiovascular Disease 25 Years Later: The Princeton Lipid Research Clinics Follow-up Study

OBJECTIVE. The goal was to assess the association of metabolic syndrome in childhood with adult cardiovascular disease 25 years later. METHODS. Data from the National Heart, Lung, and Blood Institute Lipid Research Clinics Princeton Prevalence Study (1973–1976) and the Princeton Follow-up Study (2000–2004) were used. BMI was used as the obesity measure in childhood, because waist circumference was not measured in the Lipid Research Clinics study. The adult cardiovascular disease status of participants and their parents was obtained through participant report. A logistic analysis was used to predict adult cardiovascular disease; pediatric metabolic syndrome, age at the Princeton Follow-up Study, gender, race, and parental history of cardiovascular disease were potential explanatory variables. RESULTS. Ages ranged from 6 to 19 years in the Lipid Research Clinics study and from 30 to 48 years in the Princeton Follow-up Study. There were 17 cases of cardiovascular disease in the analysis cohort in the Princeton Follow-up Study. Pediatric metabolic syndrome and age at follow-up assessment were significant predictors of cardiovascular disease. Pediatric metabolic syndrome and changes in age-specific BMI percentile from childhood to adulthood were significant predictors of adult metabolic syndrome. CONCLUSIONS. Evaluating children for metabolic syndrome could identify patients at increased risk of adult cardiovascular disease, making targeted interventions possible.
INVERSE FACTORIAL-SERIES SOLUTIONS OF DIFFERENCE EQUATIONS

Abstract We obtain inverse factorial-series solutions of second-order linear difference equations with a singularity of rank one at infinity. It is shown that the Borel plane of these series is relatively simple, and that in certain cases the asymptotic expansions incorporate simple resurgence properties. Two examples are included. The second example is the large $a$ asymptotics of the hypergeometric function ${}_2F_1(a,b;c;x)$. AMS 2000 Mathematics subject classification: Primary 34E05; 39A11. Secondary 33C05
The adolescent with a chronic condition. Part I: developmental issues

The prevalence of chronic conditions among adolescents is difficult to assess due to the lack of quality data focusing specifically on this age group, as well as the diversity in methodology and definitions used. However, surveys carried out by self administered questionnaires among in-school adolescent populations indicate that around 10% of adolescents suffer from such a condition. The aim of this paper is to analyse the reciprocal effects of chronic conditions and adolescent development by reviewing the effect of chronic disease on growth and puberty and on psychosocial development, and the effect of developmental issues on the course and management of chronic disease.
INFLUENCE OF CONCENTRATION OF RIND EXTRACT OF RED DRAGON FRUIT (HYLOCEREUS COSTARICENSIS) AGAINST THE DSSC EFFECIENCY

Research on utilization of rind extracts of red dragon fruit (hylocereus costaricensis) as sensitizer for dye sensitized solar cell (DSSC) has been conducted by reviewing influence of the concentration against the DSSC efficiency. Characterization on optical absorption at various concentrations and identification of functional groups, each using an UV-Vis spectrometer and Fourier transform infra red (FTIR), have done to the dye in the form of the extracts. The dye characterization result on optical absorption at various concentration shows that the optical absorption at range of wavelength 320-760 nm has the peak of absorbance tend to increase with increasing the concentration. Therefore the dye is capable to role as a sunlight absorber. Meanwhile, infra red absorption spectrum obtained from FTIR results indicate the presence of functional groups O-H, C=O, C=C, C-O, and C-H aromatic. Results of current-voltage characterization of DSSC show an increase in maximum power and efficiency with increasing concentration.Penelitian mengenai pemanfaatan ekstrak kulit buah naga merah (hylocereus costaricensis) sebagai penyensitif pada dye sensitized solar cell (DSSC) telah dilakukan dengan meninjau pengaruh konsentrasi ekstrak terhadap efisiensi DSSC. Terhadap dye berupa ekstrak kulit H. Costaricencis dilakukan pengujian serapan optik pada berbagai konsentrasi dan identifikasi gugus fungsi, masing-masing menggunakan spektrometer UV-Vis dan fourier transform infra red (FTIR). Hasil pengujian dye pada konsentrasi 100 %, 50 %, 33,33 %, 25%, dan 20% menunjukan serapan optik yang terjadi pada panjang gelombang 320-760 nm, memiliki puncak yang cenderung semakin tinggi seiring dengan peningkatan konsentrasi. Dye yang berasal dari ekstrak kulit H. Costaricensis ini mampu berperan sebagai sunlight absorber. Sementara itu, spektrum serapan infra red yang diperoleh dari hasil FTIR mengindikasikan adanya gugus fungsi O-H, C=O, C=C, C-O, dan C-H aromatik. Hasil karakterisasi arus-tegangan dari DSSC menunjukkan adanya peningkatan nilai daya maksimum dan efisiensi seiring peningkatan konsentrasi.
Les notions de permanence de l'objet et de causalité chez le nourrisson : Faut-il abandonner le modèle épistémologique de Jean Piaget?

La maitrise des notions de permanence de l'objet et de causalite par les nourrissons a suscite beaucoup de travaux empiriques suite a l'avenement de la technique de l'habituation visuelle. Cette presentation a pour but de synthetiser les resultats empiriques obtenus jusqu'a present, et d'evaluer s'il est pertinent ou non de maintenir le modele de Jean Piaget en psychologie de la petite enfance. A l'heure actuelle, les donnees disponibles ne permettent pas encore d'ecarter categoriquement ce modele constructiviste.
Neurological diseases differentiation analysis using inertial measurement units

Human gait is cyclic process, which is affected by various neurological disorders like Parkinson's disease (PD) or multiple sclerosis (MS). Instrumented gait analysis facilitate monitoring and diagnosing motor deficiencies; it may serve as a tool for clinicians evaluating the patients. This study aims at finding biomechanical parameters that allow separating pathological gaits via application of inertial sensors to capture the gait. The experiment involved 33 subjects divided in three groups PD, MS and healthy controls (CO). The analysis showed the statistically significant difference between stride time of the right leg in MS and CO groups, left stride time between PD and CO, stance time difference between PD and CO group, right and left leg. Hip flexion and extensions amplitudes difference was between CO and PD group, left hip flexion and extension.
Cutaneous infiltrate of chronic lymphocytic leukemia surrounding a primary squamous cell carcinoma of the skin. Report of an additional case and reflection on its pathogenesis

To ihe Editor, We read with great interest the paper by B. R. Smoller and R. A. Warnke, " Cutaneous infiltrate of chronic lymphocytic letikemia and relatiotislnp to primary cutaneous epithelial neoplasms" (1). This valuable publication reminded tis of a very similar observation which we encountered last year. The pathological findings in our own case strongly stipport the comments of these authors and prompted us to broaden their disctissiou on the pathogenesis of this unusual association. The latter is based on recent data regarding the chronic lymphocytic leukemia (CLL) biology. A 65-year-oId diabetic man with a long prior history of CLL and multiple actinic keratosis was referred to our institution because of recent and worrisome changes in a keratosis involving the right parietooccipital area of the scalp. This patient's CLL displayed a classical phenotype with CD5, CD 19, CD20, CD22, and CD23 stirface antigenic expression as well as IgMX monoclonal restriction. The disease was diagnosed in 1980 but remained stable until 1991. By that time, the progressive worsening of the hematological parameters as well as the onset of a severe hypogammaglobulinemia reqtiired the administration of several courses of a modified CHOP chemotherapy. The patient also developed multiple and intriguing arthritis-like complications which were thought to be related to an autoimmune phenomenon and which receded after each course of chemotherapy. In spite of the several therapies dispensed over several years, the patient's clinical stattis progressively worsened until the present admission. Clinical examination revealed a baldlieaded man witli multiple actinic keratosis involving the face and the scalp. One of these lesions was clinically suspected to be malignant and was surgically removed with wide margins. Histological examination demonstrated a poorly differentiated and invasive squamous cell carcinoma (SCC). In addition, the tumor cell masses were closely surrounded by a profuse and nionotonotis lymphoid infiltrate involving botli tlie stiperficial and deep dermis. The lymphocytes, which resembled those classically fotjnd in CLL, strongly expressed the B cell markers CD20 and CD79a as well as the C-D5 antigen, as demonstrated by immunohistochemistry on paraffin sections (Fig. 1). Imtnunostainings with antibodies directed against the T cell-related antigens CD3, CD8 and CD45RO only showed rare and scattered positive cells, mainly located on the periphery of the lymphoid infiltrate (Fig. 2). Moreover, microscopical examination of the resection margins clearly indicated that this CLL infiltration was exclusively confined to the caicinomatous process.
Pertussis: epidemiology and control.

Pertussis is a common, highly infectious, respiratory disease that predominantly affects children. As many as 60 million cases with more than a 1/2 million deaths occur annually. The highest incidence rates are observed in developing countries where immunization coverage is low. Accurate diagnosis under field conditions is hampered by current laboratory methods. The control of pertussis is accomplished largely through immunization and improvement of socioeconomic conditions. Although the adsorbed DPT vaccine is associated with some side effects, its benefits outweigh the risks when the vaccine sequelae are compared with the morbidity and mortality caused by the natural disease. Surveillance of pertussis and outbreak investigations provide valuable information about the disease and its effectiveness of ongoing immunization programs. (author's)
1,4a-Dimethyl-6-methylene-5-(5,5,6,6-tetracyano-2-methylcyclohex-2-enylmethyl)decahydronaphthalene-1-carboxylic acid: a trans-communic acid derivative

In the search for cancer chemopreventive agents, we have studied the Diels–Alder reaction of trans-communic acid with tetracyanoethylene in the presence of SiO2 as catalyst. The title cycloadduct, C26H30N4O2, was obtained in 75% yield. The molecules are arranged in pairs through O—H⋯O hydrogen bonds, forming an R 2 2(8) ring motif. Both the fused cyclohexyl rings adopt a chair conformation, whereas the nonfused ring adopts a half-chair conformation.
On the improvement of static force capacity of humanoid robots based on plants behavior

Humanoid robots need to interact with the environment and are constantly in rigid contact with objects. When a task must be performed, multiple contact points are responsible to add a degree of complexity to their control and, due to excessive efforts in joints, the durability of the components may be affected. This work presents the use of a recent proposed metaheuristic called Runner-Root Algorithm (RRA) applied on the static force capacity optimization of a humanoid robot. The performance of this algorithm was evaluated and compared to four well stablished methods showing promising results for RRA in this type of application.
Negative Affectivity and Inflammation: Moderation by the Glucocorticoid Receptor-9beta Polymorphism

Growing evidence suggests that negative emotions may play a role in the upregulation of innate inflammatory processes and associated disease risk. Although the hypothalamic-adrenal-pituitary (HPA) axis is believed to play a role in these associations, empirical evidence is mixed. Inconsistencies may reflect individual differences in glucocorticoid receptor (GR) sensitivity, the capacity of immune cells to respond to anti-inflammatory effects of GC-mediated signaling. We examined whether genotypes of a single nucleotide polymorphism (SNP) in the GR gene—GR-9beta (rs6198), the minor (G) allele of which confers reduced GR sensitivity—moderated associations of negative affectivity (NA) and inflammatory activity. Subjects were middle-aged men and women of European ancestry participating in two phases of the Adult Health and Behavior Project (51% F; 30-54yr). NA was assessed by the neuroticism subscale of the NEO Personality Inventory and by the Positive and Negative Affect Schedule. In a subset of participants in the second phase of the AHAB project (AHAB-2) (51% F; 30-54yr), peripheral inflammation was additionally assessed by in vitro stimulated production of IL-6, interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interleukin-8 (IL-8), while NA was also assessed by ecological momentary assessment. In bivariate and hierarchical regression analyses adjusted for potential covariates, none of the NA measures predicted any of the inflammatory cytokine levels. However, subjects homozygous for the GR-9β G allele had higher IL-6 levels than those of alternate genotypes after adjustment for age, gender, and years of school (β = .057, p = .045, R2 = .047). Although GR-9β genotype was not associated with any of the stimulated cytokines, the interaction of GR-9β was significant, and showed that greater PANAS NA scores associated with greater IL-1β levels, but only among G allele homozygotes (β = .127, p = .027, ∆R2 = .015). While these results raise the possibility that GR-9β G allele homozygotes show increased inflammatory susceptibility to negative emotionality, this pattern was not retained in analyses of circulating IL-6, or stimulated production of IL-6, TNF-α, and IL-8. We found limited evidence that genotypes of the GR-9β polymorphism moderated associations of NA and measures of peripheral inflammation.
Balance prostheses for postural control.

There is a clear need for a prosthesis that improves postural stability in the balance impaired. Such a device would be used as a temporary aid during recovery from ablative inner-ear surgery and as a permanent prosthesis for those elderly prone to falls. Research using a one-axis device that estimates body tilt and displays it to vestibulopathic subjects via an array of tactile vibrators has demonstrated feasibility. The noninvasive, vibrotactile display of body tilt helped the balance-impaired subjects to reduce their body sway during standardized tests. The motion sensor array is comprised of three MEMS linear accelerometers and three MEMS rate gyros whose sensitive axes are aligned along three orthogonal directions to provide six-degree-of-freedom (dof) motion information.
La realidad multicultural de las organizaciones: su aplicación a la ULPGC

Resumen de la tesis· doctoral realizada por la profesora Dra. Dña. Antonia Mercedes García Cabrera y dirigida por el Catedrático D. Juan Manuel García Falcón, miembros del Departamento de Economía y Dirección de Empresas de la Universidad de Las Palmas de Gran Canaria. Esta tesis fue defendida el día 18 de febrero de 1994 ante el tribunal formado por los catedráticos D. Fracisco Rubio Royo, D. Á/varo Cuervo García, Dña. Zulima Fernández Casariego, D. Juan Hemangómez Barahona y D. Antonio Marrero Hernández, obteniendo la máxima calificación de «Apto Cum Laude». 1 concepto de cultura corporativa es relativamente nuevo en el campo de la Teoría de la Organización y, más aún, en el de la Dirección Estratégica. En efecto, aunque con anterioridad el tema de la cultura ha sido ampliamente tratado bajo una perspectiva antropológica, su introducción y aceptación en nuestro ámbito académico y profesional se produjo a principios de la pasada década. Muchos autores han destacado la importancia de este nuevo tópico, directamente relacionado con la dimensión humana de la organización y estrechamente vinculado al concepto de estrategia empresarial, pues constituye el principal factor determinante de su implementación con éxito o fracaso (Livian, 1988; Mintzberg, 1988).
Oxygen enhances lethal effect of high‐intensity, ultrashort electrical pulses

The study explored the effect of ambient oxygen on mammalian cell survival after exposure to 10 ns duration, high voltage electrical pulses (nsEP, 80–90 or 120–130 kV/cm; 200–400 pulses per exposure). Cell samples were equilibrated with pure nitrogen, atmospheric air, or pure oxygen prior to the nsEP treatment and were returned to the incubator (air + 5% CO2) shortly after the exposure. The experiments established that survival of hypoxic Jurkat and U937 cells exceeded that of air‐equilibrated controls about twofold (P < .01). Conversely, saturation of the medium with oxygen prior to exposure decreased Jurkat cell survival about 1.5 times, P < . 01. Attenuation of the cytotoxic effect under hypoxic conditions resembled a well‐known effect of oxygen on cell killing by sparsely ionizing radiations and may be indicative of the similarity of underlying cell damage mechanisms. Bioelectromagnetics 27:221–225, 2006. Published 2005 Wiley‐Liss, Inc.
Iron Deficiency, Helicobacter Infection and Gastritis

Despite elegant regulatory mechanisms, iron deficiency anemia (IDA) remains one of the most common nutritional deficiencies of mankind. Iron deficiency is the result of an interplay between increased host requirements, limited external supply, and increased blood loss. When related to increased physiologic needs associated with normal development, iron deficiency is designated physiologic or nutritional. By contrast, pathological iron deficiency, with the exception of gross menorrhagia, is most often the result of gastrointestinal disease associated with abnormal blood loss or malabsorption. If gastroenterologic evaluation fails to disclose a likely cause of IDA, or in patients refractory to oral iron treatment, screening for celiac disease (anti-tissue transglutaminase antibodies), autoimmune gastritis (gastrin, anti-parietal or anti-intrinsic factor antibodies), and Helicobacter pylori (IgG antibodies and urease breath test) is recommended. Recent studies indicate that 20–27% of patients with unexplained IDA have autoimmune gastritis, about 50% have evidence of active H. pylori infection, and 4–6% have celiac disease. The implications for abnormal iron absorption of celiac disease or autoimmune gastritis are obvious. In patients with unexplained IDA and H. pylori infection, cure of refractory IDA by H. pylori eradication offers strong evidence for a cause-and-effect relation between H. pylori infection and unexplained IDA. Stratification by age cohorts in autoimmune gastritis implies a disease presenting as IDA many years before the establishment of clinical cobalamin deficiency. It is likely caused by an autoimmune process triggered by antigenic mimicry between H. pylori epitopes and major autoantigens of the gastric mucosa. Recognition of the respective roles of H. pylori and autoimmune gastritis in the pathogenesis of iron deficiency may have a strong impact on the diagnostic workup and management of unexplained, or refractory IDA.
Chemogenomics: Models of Protein-Ligand Interaction Space

G-Protein-coupled receptors (GPCRs) are among the most important drug targets. Because of a shortage of 3D crystal structures, most of the drug design for GPCRs has been ligand-based. We propose a novel, rough set-based proteochemometric approach to the study of receptor and ligand recognition. The approach is validated on three datasets containing GPCRs. In proteochemometrics, properties of receptors and ligands are used in conjunction and modeled to predict binding affinity. The rough set (RS) rule-based models presented herein consist of minimal decision rules that associate properties of receptors and ligands with high or low binding affinity. The information provided by the rules is then used to develop a mechanistic interpretation of interactions between the ligands and receptors included in the datasets. The first two datasets contained descriptors of melanocortin receptors and peptide ligands. The third set contained descriptors of adrenergic receptors and ligands. All the rule models induced from these datasets have a high predictive quality. An example of a decision rule is If R1_ligand(Ethyl) and TM helix 2 position 27(Methionine) then Binding(High). The easily interpretable rule sets are able to identify determinative receptor and ligand parts. For instance, all three models suggest that transmembrane helix 2 is determinative for high and low binding affinity. RS models show that it is possible to use rule-based models to predict ligand-binding affinities. The models may be used to gain a deeper biological understanding of the combinatorial nature of receptor-ligand interactions.
Are Short Telomeres Hallmarks of Cancer Recurrence?

Exposure to radiation and some chemotherapeutic agents is associated with an increased risk of developing second cancers. Short telomeres are almost universally associated with malignant cancer progression. An unanswered question is whether inherited short telomeres or therapy-related telomere shortening is a biomarker of the development of second malignant neoplasms. Clin Cancer Res; 20(4); 779–81. ©2013 AACR.