Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease

Slow wave activity during non–rapid eye movement sleep decreases with disease progression in patients with Alzheimer’s disease. Losing sleep over Alzheimer’s disease In patients with Alzheimer’s disease (AD), amyloid-β (Aβ) plaques and tau protein tangles accumulate in the brain long before the appearance of clinical symptoms. Early intervention is critical for slowing neurodegeneration and disease progression. Therefore, reliable markers of early AD are needed. Lucey et al. analyzed sleep patterns in aging cognitively normal subjects and showed that non–rapid eye movement (NREM) sleep negatively correlated with tau pathology and Aβ deposition in several brain areas. The results show that alterations in NREM sleep may be an early indicator of AD pathology and suggest that noninvasive sleep analysis might be useful for monitoring patients at risk for developing AD. In Alzheimer’s disease (AD), deposition of insoluble amyloid-β (Aβ) is followed by intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic loss, brain atrophy, and cognitive impairment. By the time even the earliest clinical symptoms are detectable, Aβ accumulation is close to reaching its peak and neocortical tau pathology is frequently already present. The period in which AD pathology is accumulating in the absence of cognitive symptoms represents a clinically relevant time window for therapeutic intervention. Sleep is increasingly recognized as a potential marker for AD pathology and future risk of cognitive impairment. Previous studies in animal models and humans have associated decreased non–rapid eye movement (NREM) sleep slow wave activity (SWA) with Aβ deposition. In this study, we analyzed cognitive performance, brain imaging, and cerebrospinal fluid (CSF) AD biomarkers in participants enrolled in longitudinal studies of aging. In addition, we monitored their sleep using a single-channel electroencephalography (EEG) device worn on the forehead. After adjusting for multiple covariates such as age and sex, we found that NREM SWA showed an inverse relationship with AD pathology, particularly tauopathy, and that this association was most evident at the lowest frequencies of NREM SWA. Given that our study participants were predominantly cognitively normal, this suggested that changes in NREM SWA, especially at 1 to 2 Hz, might be able to discriminate tau pathology and cognitive impairment either before or at the earliest stages of symptomatic AD.
Wavelet-based multifractal analysis of the HF channel scattering function

We have developed a new multifractal modelling framework, called complex multifractal dimension, for characterizing the HF channel. Using the wavelet packet decomposition, and a special fractal dimension algorithm, the complex multifractal dimension provides a local characterization and a coherent physical interpretation, contrarily to others multifractal spectrums. We have adopted the scattering function as a tool for the ionosphere channel characterization. The non-homogeneity of the scattering function expressed according to the propagation time and Doppler shift led us to split it into two one dimensional vectors. Our analysis was performed over both theoretical examples and experimental scattering functions of the ionospheric channel obtained with an experimental support: STUDIO station.
TOWARDS MISTAKE-AWARE SYSTEMS

OF THE DISSERTATION Towards Mistake-Aware Systems by Fábio Abreu Dias de Oliveira Dissertation Director: Ricardo Bianchini The complexity of today’s enterprise computer systems poses a major challenge to system administrators, with a multitude of inter-related software components distributed in non-obvious ways across multiple computers. Not surprisingly, several studies have shown that human mistakes are an important source of outages and incorrect system behavior. To make matters worse, as computers permeate all aspects of our lives, higher demands are placed on the availability and correct operation of many computer systems. Given this state-of-affairs, we envisioned that systems must gracefully tolerate human mistakes made during system administration and operation. To realize our vision, we first studied human operator behavior and mistakes by means of live experiments with volunteers and a survey with database administrators. The results of this study led us to investigate a few techniques for dealing with mistakes, namely, validation of operator actions and model-based validation. Our research efforts culminate in a radically different approach, which we call mistake-aware systems management. We evaluate the effectiveness of validation of operator actions applied to databases, model-based validation, and mistake-aware systems management through a combination of live operator experiments, operator-emulation experiments, and mistakeinjection experiments in a realistic prototype three-tier Internet service.
Aerobic exercise and caloric reduction should be the key lifestyle modifications in obese patients with GERD: authors’ reply

1. Hsu C-S, Wang P-C, Chen J-H, et al. Increasing insulin resistance is associated with increased severity and prevalence of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2011; 34: 994–1004. 2. Lee YC, Yen AM, Tai JJ, et al. The effect of metabolic risk factors on the natural course of gastro-oesophageal reflux disease. Gut 2009; 58: 174–81. 3. Chung SJ, Kim D, Park MJ, et al. Metabolic syndrome and visceral obesity as risk factors for reflux oesophagitis: a cross-sectional case-control study of 7078 Koreans undergoing health check-ups. Gut 2008; 57: 1360–5. 4. Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CA Jr. Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 2006; 354: 2340–8. 5. Katzmarzyk PT, Leon AS, Wilmore JH, et al. Targeting the metabolic syndrome with exercise: evidence from the HERITAGE family study. Med Sci Sports Exerc 2003; 35: 1703–9. 6. Ahmadi N, Eshaghian S, Huizenga R, Sosnin K, Ebrahimi R, Siegel R. Effects of intense exercise and moderate caloric restriction on cardiovascular risk factors and inflammation. Am J Med 2011 [Epub ahead of print].
The Interface as Sign and as Aesthetic Event

This chapter contains sections titled: A Bit More on Aesthetic Computing, An Example of Computing and Art, The Computational View, Aesthetic Aspects of the Example, The Semiotic View, Interactive Use of Software: the Interface as Sign, Interactive Use of Software: An Aesthetic Event, Acknowledgment, References
Group Nutrition Education Classes for Older Adults

Abstract A thorough search of the literature revealed only nine articles published since 1993 that focused on nutrition education for older adults attending group classes and that measured outcomes. A table summarizes the reports, including the theoretical bases, descriptions of interventions, participants and comparison groups, program outcomes, methods of verification, and followup after interventions. Only three of the studies explicitly indicated that elements of a stated behavioral change theory had been incorporated. All of the educators employed a variety of older adult educational strategies to enhance learning. Six research teams reported on classes where nearly half or more of the participants represented minority groups. Six studies included comparison groups. Types of outcomes included measurements of change in knowledge, attitudes beliefs, behaviors, and/or physiological measures, but the actual variables examined differed among reports. No consistent patterns were detected among reported outcomes. The longest follow-up after interventions ceased was seven months. The review addresses issues raised from an analysis of the quantity, quality and findings of the articles and makes suggestions for future research and offers preliminary ideas for developing group nutrition education classes for older adults. This is one of a series of reviews of recent literature on nutrition education for older adults.
Ekstraksi Opini dengan Menggunakan Pendekatan Association Rule Mining

Abstrak Transaksi secara online sudah berkembang secara pesat dewasa ini. Jumlah produk yang terjual secara online semakin bertambah banyak dan beranekaragam jenisnya. Sebuah review tentang produk acap kali diberikan oleh konsumen untuk mengomentari produk-produk yang sudah mereka beli. Pada jenis produk dengan brand yang sudah terkenal memiliki review yang sangat banyak. Seharusnya review dari konsumen bisa dimanfaatkan produsen sebagai feedback dan digunakan calon konsumen sebagai referensi saat akan membeli barang. Review produk yang jumlahnya semakin banyak akan menyulitkan pembaca jika harus membacanya satu persatu. Solusinya adalah dengan mengidentifikasi fitur produk secara spesifik dari review yang sudah ditulis konsumen. Tugas akhir ini dilakukan untuk mengidentifikasi masalah featured- based opinion summarization dari review konsumen. Proses identifikasi ini terdiri dari dua tahap utama, yaitu : (1) ekstraksi fitur produk yang sudah direview oleh konsumen (feature extraction); dan (2) identifikasi polaritas fitur untuk menentukan polaritas kalimat opini (sentiment analysis). Metode yang digunakan pada opinion extraction ini adalah dengan metode association rule mining dengan algoritma apriori. Berdasarkan hasil pengujian, penggunaan metode association rule mining terbukti dapat mengekstrak fitur produk. Fitur yang sudah diekstraksi tersebut kemudian dicek pada setiap kalimat untuk menemukan orientasi opini dengan bantuan SentiWordNet sehingga didapatkan polaritas opini fitur yang dibicarakan oleh konsumen pada review. Kata kunci : Association rule mining, Feature extraction, Opinion summarization, Sentiment analysis
Quality of life in cancer patients undergoing chemotherapy

poważny problem współczesnych społeczeństw. Celem badań była ocena wpływu chemioterapii na jakość życia pacjentów onkologicznych. Materiał i metody: Badaniem objęto 182 pacjentów z chorobą nowotworową leczonych w Centrum Onkologii w Bydgoszczy od września 2008 r. do czerwca 2009 r. W celu zbadania wpływu chemioterapii na jakość życia badaniami objęto dwie grupy chorych: grupę A liczącą 77 osób z postawioną diagnozą choroby nowotworowej przed rozpoczęciem leczenia cytostatykami i grupę B składającą się ze 105 pacjentów poddanych chemioterapii standardowej w warunkach szpitalnych z rozpoznaniem choroby nowotworowej. Do pomiaru jakości życia zastosowano standaryzowany kwestionariusz EORTC QLQ-C30 (wersja 3.0) dla chorych onkologicznych, opracowany przez Europejską Grupę Badającą Jakość Życia. Wyniki: Chorzy z grupy B w trakcie chemioterapii wykazywali niższe parametry jakości życia i stanu zdrowia oraz większe natężenie objawów chorobowych, zwłaszcza w występowaniu nudności, niż pacjenci z grupy A z postawioną diagnozą choroby nowotworowej przed rozpoczęciem leczenia cytostatykami. Grupa A także charakteryzowała się znacznie zaniżonymi parametrami jakości życia i to w każdym zakresie wynikającym z konstrukcji zastosowanego narzędzia badawczego. Zróżnicowanie między grupami było nieistotne statystycznie. Wnioski: Choroba nowotworowa i związane z nią leczenie (chemioterapia) pogarszają jakość życia. Brak statystycznie istotnych różnic między badanymi grupami pozwala domniemywać, że jakość życia osób dotkniętych chorobą nowotworową najbardziej obniża sam fakt postawienia diagnozy. Chorzy poddani chemioterapii najgorzej funkcjonują w zakresie emocjonalnym. Najbardziej dla nich dokuczliwe objawy to zmęczenie, trudności ze snem oraz ból.
Eingeboren? Oder nur eingewandert ins Digitale? Warum die Abkehr vom Mythos einer Generation von Digital Natives Voraussetzung einer verantwortungsorientierten Bildungs- und Gesellschaftspolitik ist

In die digitale Welt hineingeboren sein heisst, instinktiv die Technik beherrschen, intuitiv Malware erkennen, virtuos im Social Web kommunizieren, effizient multi-tasken: der Digital Native -Mythos, der sich um die Generation in und nach den 1980-ern Geborener rankt, ist tückisch. Er entbehrt hinreichender wissenschaftli-cher Grundlagen und ist eine Überschätzung, die dazu verleitet, pädagogische Überlegungen zu vernachlässigen und den Einsatz von Geräten wie z.B. Tablets oder Laptops im Unterricht an Schulen oder Hochschulen zur Lösung aller Probleme hochzustilisieren. Diese Auffassung spiegelt auch der an eine Grundgesetzände-rung geknüpfte Digitalpakt wider, mit dem der Deutsche Bundestag 2018 dem Bund direkten Einfluss auf die Schulentwicklung verschaffen wollte. Die Länder haben dies vorerst gestoppt, auch weil sie durch eine solche Verfassungsänderung ihre Pfründe schwinden sahen. Dieser Stopp ist eine Chance. Denn er liefert noch eine Gelegenheit zum grundsätzlichen Überdenken – hin zu einer stärker auf ge-sellschaftliche Bedürfnisse ausgerichteten, das Justieren eines ethischen Kompasses ausdrücklich einbindenden Strategie. Dieser Beitrag erläutert die Entstehung der Klassifizierung von „ Digital Natives “ 1 und erörtert, warum diese zu ersetzen
Managing the Flow of Technology: Technology Transfer and the Dissemination of Technological Information Within the R&D Organization (Book Review)

The original edition of this book summarized more than a decade of work on communications flow in science and engineering organizations, showing how human and organizational systems could be restructured to bring about improved productivity and better person-to-person contact. While many studies have been done since then, few of them invalidate the general conclusions and recommendations Allen offers. In a new preface he points out new developments, noting areas that need some modification, elaboration, or extension, and directing readers to the appropriate journal articles where the findings, are reported. The first three chapters provide an overview of the communication system in technology, present the author's research methods, and describe differences in the career paths and goals of engineers and scientists that cause special problems for organizations. The book then discusses how technological information is acquired by the R & D organization, shows how critical technical communication within the laboratory is for R & D performance, and originates the idea of the "gatekeeper," the person who links his or her organization to the world at large. Concluding chapters take up the influence of formal and informal organization and of architecture and office layouts on communication. Many of these ideas have been successfully incorporated by architects and managers in the design of new R & D facilities and complexes. Suggested Citation Handle: RePEc:mtp:titles:0262510278 Download reference as HTML Thomas J. Allen, 1984. "Managing the Flow of Technology: Technology Transfer and the Dissemination of Technological Information Within the R&D Organization," MIT Press Books, The MIT Press, edition 1, volume 1, number 0262510278, November. More services and features MyIDEAS Follow serials, authors, keywords & more New papers by email Subscribe to new additions to RePEc Author registration Public profiles for Economics researchers MPRA Upload your paper to be listed on RePEc and IDEAS EconAcademics Blog aggregator for economics research Plagiarism Cases of plagiarism in Economics Rankings Various rankings of research in Economics & related fields RePEc Genealogy Who was a student of whom, using RePEc RePEc Biblio Curated articles & papers on various economics topics Job market papers RePEc working paper series dedicated to the job market Fantasy league Pretend you are at the helm of an economics department Services from the StL Fed Data, research, apps & more from the St. Louis Fed IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.
Association of depression and chronic 
lower-back pain

Method: One hundred consecutive patients visiting an orthopaedic out patients department (OPD) with chronic lower – back pain in a tertiary hospital were included. They were interviewed for major depressive disorder (MDD) using DSM-5 and assessed for the severity of depression, health-related quality of life and sleep quality using the Hamilton Depression Rating Scale, Health Questionnaire Short Form (SF-36) and Pittsburgh Sleep Quality Index (PSQI), respectively. Proportion was compared using chi-square test, scores of scales were compared using the Mann – Whitney test and Kruskal-Wallis test followed by Dunn’s post-hoc multiple comparisons. Statistical data were analyzed by Graph Pad InStat version 3.06. A p value of <0.05 was considered statistically significant.
Cascaded H-Bridge Five Level Inverter for Grid Connected PV System using PID Controller

Photovoltaic energy conversion becomes main focus of many researches due to its promising potential as source for future electricity and has many advantages than the other alternative energy sources like wind, solar, ocean, biomass, geothermal etc. In Photovoltaic power generation multilevel inverters play a vital role in power conversion. The three different topologies, diode-clamped (neutral-point clamped) inverter, capacitor-clamped (flying capacitor) inverter and cascaded h-bridge multilevel inverter are widely used in these multilevel inverters. Among the three topologies, cascaded h-bridge multilevel inverter is more suitable for photovoltaic applications since each pv array can act as a separate dc source for each h-bridge module. This paper presents a single phase Cascaded H-bridge five level inverter for grid-connected photovoltaic application using sinusoidal pulse width modulation technique. This inverter output voltage waveform reduces the harmonics in the generated current and the filtering effort at the input. The control strategy allows the independent control of each dc-link voltages and tracks the maximum power point of PV strings. This topology can inject to the grid sinusoidal input currents with unity power factor and achieves low harmonic distortion. A PID control algorithm is implemented in Arm Processor LPC2148. The validity of the proposed inverter is verified through simulation and is implemented in a single phase 100W prototype. The results of hardware are compared with simulation results. The proposed system offers improved performance over conventional three level inverter in terms of THD.
SPADE: A Tool for Performance and Reliability Evaluation

A model for the stochastic analysis of directed acyclic graphs is developed. These graphs represent event-procedure networks where the distribution function associated with an event is assumed to be a variant of the phase-type distribution. Events may occur sequentially, probabilistically, or concurrently. The distribution function of the graph execution time is computed in a semi-symbolic form. Applications of the model for the evaluation of concurrent program execution time and to the reliability analysis of fault-tolerant systems are discussed.
Research on Multilevel Secure Database Inference Channel

In multi-level security database system, the inference problem is that a low security level user using accessible data and his own knowledge and to infer confidential information of higher security level, which constitute an attack on the database. This paper introduces a formal description of multi-level secure database systems inference channels and analyzes several common inference channels and its solution.
Managing Health Risks of Drug-Resistant Tuberculosis

The recent report of a patient with drug-resistant tuberculosis (TB) who traveled on multiple international flights focused attention on TB in general, and drug resistance in particular. TB requires multiple agents for treatment, the treatment is prolonged, and inadequate or inappropriate treatment invariably results in drug resistance. Both multidrug-resistant TB and extensively drug-resistant TB have been reported from all regions of the world. Drug-resistant TB has fewer treatment options; treatment courses are much longer, more expensive, and are associated with poorer outcomes. The HIV epidemic has increased the burden of TB in many countries and drug-resistance TB rates are at an all-time high. Diagnosis of drug resistance using conventional methods can take several weeks, during which transmission to other persons can occur. Some new diagnostic tests seem promising; efforts are underway to implement them in resource poor areas where the burden of TB is highest. There is renewed interest in new drugs with anti-TB activity; newer uses for existing drugs are also being studied. Controlling drug-resistant TB requires improvements in diagnostic capabilities, better treatment regimens, and collaboration between HIV and TB treatment programs.
Buprenorphine and Naloxone (Suboxone) Efficacy Compared With Methadone and Challenges in Treating Opiate Addiction

By Todd M. Carpenter, RN, BSN Washington State University May, 2011 •• Submitting to: American Journal on Addictions • Purpose: To identify the efficacy and barriers that patients face concerning treatment of opiate • • addiction with buprenorphine and naloxone (Suboxone) through an examination of current peer• • reviewed literature comparing buprenorphine and naloxone to that of methadone and the barriers to treatment. • • Conclusions: Access to treatment, social stigma, and overall treatment costs are primary barriers • • • to persons with opiate addictions seeking treatment. Buprenorphine and naloxone treatment • • offers equal efficacy to the standard treatment of methadone, with pharmacologic advantages, lower cost with office-based treatment, and increased access to those seeking addiction management without the need to attend a methadone clinic and avoid the stigma associated with • opioid addiction. • Implications for Practice: More research is required to examine long-term outcomes with buprenorphine and naloxone managed addiction treatment. Currently, this treatment is only • •• 11 • • • • • •• • • • • • • • • • • • • • • • • • • • • •• •• • • •• • •• • • • • available through qualified physicians, hindering access to care. Allowing nurse practitioners to have prescriptive authority would increase access to treatment for addicts in an office-based • setting.
Harnessing Artificial Intelligence to Deliver Real-Time Intelligence and Business Process Improvements

Abstract As demand for data scientists in audit/Governance, risk management and compliance (GRC), and industry in general, outpaces supply, data science in a box—packaged analytics powered by artificial intelligence (AI) and guided machine learning—can bridge the gap to bring analytics to every major enterprise. Packaged analytics harness the power of AI and machine learning technologies to help operations, finance executives, and GRC professionals do their jobs better; optimize business processes; and deliver actionable insights for better decision making. This article will explore real-world case studies of how companies have used packaged analytics to achieve process improvements, better oversight over financial spend, and significant return on investment. It is a guide to internal auditors and their GRC counterparts on what is available and suggests they can partner or use the products independently and significantly contribute to their companies.
Automatic Record Matching in Cooperative Information Systems

The paper describes an algorithm for automatic record matching in cooperative information systems. The algorithm is based on the well-known Sorted Neighborhood Method. The original contribution is on the proposal of a method to automatically choose the key for record matching. The performances of the algorithm are compared with previous literature results; the algorithm detects a higher percentage of correct duplicates and a lower percentage of false positive, on a single key sorting pass.